LOCUS 013_IIG_Bs09_SNP 3833270 bp DNA circular UNA 12-JAN-2021 DEFINITION Bacillus subtilis strain Delta6 (hybrid trycycler assembly). ACCESSION urn.local...1d9-cvskbt5 VERSION urn.local...1d9-cvskbt5 KEYWORDS . SOURCE ORGANISM . FEATURES Location/Qualifiers S_feature complement(3833160..658) /Source="Nicolas_S_feature" /locus_tag="new_299_1067_c" /HighExp="S4, LoTm, S3, C30, S5, S7, S6, T5.0H, S8, M9-stat" /AntisenseName="dnaA" /AntisenseCor="-0.57810076860528403" /AntisenseRegPval="-24.7" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S4" CDS 1..1341 /gene="dnaA" /locus_tag="BSU_00010" /old_locus_tag="BSU00010" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:2167836, 2846289, 12682299, 16120674, 1779750, 28166228" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2167836, 2846289, 12682299, 16120674, 1779750, 28166228; Product type f : factor" /codon_start=1 /transl_table=11 /product="chromosomal replication initiator informational ATPase" /protein_id="NP_387882.1" /db_xref="EnsemblGenomes-Gn:BSU00010" /db_xref="EnsemblGenomes-Tr:CAB11777" /db_xref="GOA:P05648" /db_xref="InterPro:IPR001957" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR010921" /db_xref="InterPro:IPR013159" /db_xref="InterPro:IPR013317" /db_xref="InterPro:IPR018312" /db_xref="InterPro:IPR020591" /db_xref="InterPro:IPR024633" /db_xref="InterPro:IPR027417" /db_xref="PDB:4TPS" /db_xref="SubtiList:BG10065" /db_xref="UniProtKB/Swiss-Prot:P05648" /translation="MENILDLWNQALAQIEKKLSKPSFETWMKSTKAHSLQGDTLTIT APNEFARDWLESRYLHLIADTIYELTGEELSIKFVIPQNQDVEDFMPKPQVKKAVKED TSDFPQNMLNPKYTFDTFVIGSGNRFAHAASLAVAEAPAKAYNPLFIYGGVGLGKTHL MHAIGHYVIDHNPSAKVVYLSSEKFTNEFINSIRDNKAVDFRNRYRNVDVLLIDDIQF LAGKEQTQEEFFHTFNTLHEESKQIVISSDRPPKEIPTLEDRLRSRFEWGLITDITPP DLETRIAILRKKAKAEGLDIPNEVMLYIANQIDSNIRELEGALIRVVAYSSLINKDIN ADLAAEALKDIIPSSKPKVITIKEIQRVVGQQFNIKLEDFKAKKRTKSVAFPRQIAMY LSREMTDSSLPKIGEEFGGRDHTTVIHAHEKISKLLADDEQLQQHVKEIKEQLK*" /label="dnaA CDS" gene 1..1341 /gene="dnaA" /locus_tag="BSU_00010" /old_locus_tag="BSU00010" /label="dnaA gene" promotor_-10 complement(631..649) /Source="Nicolas_upshift_promotors" /id="U3" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1004 /SigmaFactorBS="ttcttcgtgtaatgtgttaaatgtatggaaaaattcttcctg ggtttGTTCTTtccccgctaaaaattGAATATCATCTATCAAAAGcacatcaacattt c" /listShort="S4, S2" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(657) /Source="Nicolas_upshifts" /id="U3" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1004 /SigmaFactorBS="ttcttcgtgtaatgtgttaaatgtatggaaaaattcttcctg ggtttGTTCTTtccccgctaaaaattGAATATCATCTATCAAAAGcacatcaacattt c" /listShort="S4, S2" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(665..670) /Source="Nicolas_upshift_promotors" /id="U3" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1004 /SigmaFactorBS="ttcttcgtgtaatgtgttaaatgtatggaaaaattcttcctg ggtttGTTCTTtccccgctaaaaattGAATATCATCTATCAAAAGcacatcaacattt c" /listShort="S4, S2" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1342..1529 /Source="Nicolas_S_feature" /locus_tag="new_1751_1938" /HighExp="G150, Heat, G180, G135, Paraq, Oxctl, dia0, LBGstat, S1, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S5" CDS 1530..2666 /gene="dnaN" /locus_tag="BSU_00020" /old_locus_tag="BSU00020" /EC_number="2.7.7.7" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:2846289, 11395445, 12682299, 20453097, 23228104, 28878042" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2846289, 11395445, 12682299, 20453097, 23228104, 28878042; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase III (beta subunit)" /protein_id="NP_387883.1" /db_xref="EnsemblGenomes-Gn:BSU00020" /db_xref="EnsemblGenomes-Tr:CAB11778" /db_xref="GOA:P05649" /db_xref="InterPro:IPR001001" /db_xref="InterPro:IPR022634" /db_xref="InterPro:IPR022635" /db_xref="InterPro:IPR022637" /db_xref="PDB:4TR6" /db_xref="SubtiList:BG10066" /db_xref="UniProtKB/Swiss-Prot:P05649" /translation="MKFTIQKDRLVESVQDVLKAVSSRTTIPILTGIKIVASDDGVSF TGSDSDISIESFIPKEEGDKEIVTIEQPGSIVLQARFFSEIVKKLPMATVEIEVQNQY LTIIRSGKAEFNLNGLDADEYPHLPQIEEHHAIQIPTDLLKNLIRQTVFAVSTSETRP ILTGVNWKVEQSELLCTATDSHRLALRKAKLDIPEDRSYNVVIPGKSLTELSKILDDN QELVDIVITETQVLFKAKNVLFFSRLLDGNYPDTTSLIPQDSKTEIIVNTKEFLQAID RASLLAREGRNNVVKLSAKPAESIEISSNSPEIGKVVEAIVADQIEGEELNISFSPKY MLDALKVLEGAEIRVSFTGAMRPFLIRTPNDETIVQLILPVRTY*" /label="dnaN CDS" gene 1530..2666 /gene="dnaN" /locus_tag="BSU_00020" /old_locus_tag="BSU00020" /label="dnaN gene" downshifts 2650 /Source="Nicolas_upshifts" /id="D1" /incds=0 /nref=29 /ntot=161 /MaxReadThrough="5.22584" /MaxDrop="4.17087" /score="21.887269" /energy="-14.2" /TU="U1" /idTUdmin="U1" /TUdmin="-572" /isTUend="FALSE" /label="downshifts" promotor_-35 2731..2735 /Source="Nicolas_upshift_promotors" /id="U4" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.826173826173826" /psig="0.999000999001" /xcortree=2587 /SigmaFactorBS="ttctattcggtatctgctccgacaagttttcCCTTTccctaa ttcgttttttTTTAGTACAATTAGATATTAgtgatatttgaaagaggtcgatataatg g" /listShort="yaaA, recF, yaaB, gyrB, S6, gyrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2752..2771 /Source="Nicolas_upshift_promotors" /id="U4" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.826173826173826" /psig="0.999000999001" /xcortree=2587 /SigmaFactorBS="ttctattcggtatctgctccgacaagttttcCCTTTccctaa ttcgttttttTTTAGTACAATTAGATATTAgtgatatttgaaagaggtcgatataatg g" /listShort="yaaA, recF, yaaB, gyrB, S6, gyrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2760 /Source="Nicolas_upshifts" /id="U4" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.826173826173826" /psig="0.999000999001" /xcortree=2587 /SigmaFactorBS="ttctattcggtatctgctccgacaagttttcCCTTTccctaa ttcgttttttTTTAGTACAATTAGATATTAgtgatatttgaaagaggtcgatataatg g" /listShort="yaaA, recF, yaaB, gyrB, S6, gyrA" /GFF_Attribute="listLong" /label="upshifts" CDS 2797..3012 /gene="rlbA" /locus_tag="BSU_00030" /old_locus_tag="BSU00030" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:24637032, 24939895" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 24637032, 24939895; Product type f: factor" /codon_start=1 /transl_table=11 /product="RNA binding protein involved in ribosome maturation" /protein_id="NP_387884.1" /db_xref="EnsemblGenomes-Gn:BSU00030" /db_xref="EnsemblGenomes-Tr:CAB11779" /db_xref="GOA:P05650" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR014330" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG10067" /db_xref="UniProtKB/Swiss-Prot:P05650" /translation="MANPISIDTEMITLGQFLKLADVIQSGGMAKWFLSEHEVLVNDE PDNRRGRKLYVGDVVEIEGFGSFQVVN*" /label="rlbA CDS" gene 2797..3012 /gene="rlbA" /locus_tag="BSU_00030" /old_locus_tag="BSU00030" /label="rlbA gene" CDS 3028..4140 /gene="recF" /locus_tag="BSU_00040" /old_locus_tag="BSU00040" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:15186413, 16061691, 16385024, 22342069" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15186413, 16061691, 16385024, 22342069; Product type f: factor" /codon_start=1 /transl_table=11 /product="RecA filament-DNA complex stabilisation, ssDNA and dsDNA binding, ATP binding" /protein_id="NP_387885.1" /db_xref="EnsemblGenomes-Gn:BSU00040" /db_xref="EnsemblGenomes-Tr:CAB11780" /db_xref="GOA:P05651" /db_xref="InterPro:IPR001238" /db_xref="InterPro:IPR003395" /db_xref="InterPro:IPR018078" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10068" /db_xref="UniProtKB/Swiss-Prot:P05651" /translation="MYIQNLELTSYRNYDHAELQFENKVNVIIGENAQGKTNLMEAIY VLSMAKSHRTSNDKELIRWDKDYAKIEGRVMKQNGAIPMQLVISKKGKKGKVNHIEQQ KLSQYVGALNTIMFAPEDLNLVKGSPQVRRRFLDMEIGQVSPVYLHDLSLYQKILSQR NHFLKQLQTRKQTDRTMLDVLTDQLVEVAAKVVVKRLQFTAQLEKWAQPIHAGISRGL EELTLKYHTALDVSDPLDLSKIGDSYQEAFSKLREKEIERGVTLSGPHRDDVLFYVNG RDVQTYGSQGQQRTTALSLKLAEIDLIHEEIGEYPILLLDDVLSELDDYRQSHLLHTI QGRVQTFVTTTSVDGIDHETLRQAGMFRVQNGALVK*" /label="recF CDS" gene 3028..4140 /gene="recF" /locus_tag="BSU_00040" /old_locus_tag="BSU00040" /label="recF gene" misc_feature 3226..3245 /Source="Nicolas_upshift_promotors" /id="U5" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2750 /SigmaFactorBS="cggacatcaaatgacaaagaacttatacggtgggacaaagac TATGCTAAAATAGAGGGAAGagtgatgaagcaaaacggggcgatcccgatgcagctcg t" /listShort="yaaB, gyrB, S6, gyrA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3244 /Source="Nicolas_upshifts" /id="U5" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2750 /SigmaFactorBS="cggacatcaaatgacaaagaacttatacggtgggacaaagac TATGCTAAAATAGAGGGAAGagtgatgaagcaaaacggggcgatcccgatgcagctcg t" /listShort="yaaB, gyrB, S6, gyrA" /GFF_Attribute="listLong" /label="upshifts" CDS 4158..4403 /gene="remB" /locus_tag="BSU_00050" /old_locus_tag="BSU00050" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:19363116" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19363116; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of extracellular matrix formation" /protein_id="NP_387886.2" /db_xref="EnsemblGenomes-Gn:BSU00050" /db_xref="EnsemblGenomes-Tr:CAB11781" /db_xref="InterPro:IPR007169" /db_xref="SubtiList:BG10069" /db_xref="UniProtKB/Swiss-Prot:P37525" /translation="MYIHLGDDFVVSTRDIVGIFDFKANMSPIVEEFLKKQKHKVVPS VNGTPKSIVVTVQNIYYSPLSSSTLKKRAQFMFEIDS*" /label="remB CDS" gene 4158..4403 /gene="remB" /locus_tag="BSU_00050" /old_locus_tag="BSU00050" /label="remB gene" CDS 4458..6374 /gene="gyrB" /locus_tag="BSU_00060" /old_locus_tag="BSU00060" /EC_number="5.99.1.3" /function="16.2: Construct biomass (Anabolism)" /function="16.9: Replicate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12682299, 12767818, 17320901" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 12767818, 17320901; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA gyrase (subunit B)" /protein_id="NP_387887.1" /db_xref="EnsemblGenomes-Gn:BSU00060" /db_xref="EnsemblGenomes-Tr:CAB11782" /db_xref="GOA:P05652" /db_xref="InterPro:IPR001241" /db_xref="InterPro:IPR002288" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR011557" /db_xref="InterPro:IPR013506" /db_xref="InterPro:IPR013759" /db_xref="InterPro:IPR013760" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR018522" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR034160" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10070" /db_xref="UniProtKB/Swiss-Prot:P05652" /translation="MEQQQNSYDENQIQVLEGLEAVRKRPGMYIGSTNSKGLHHLVWE IVDNSIDEALAGYCTDINIQIEKDNSITVVDNGRGIPVGIHEKMGRPAVEVIMTVLHA GGKFDGSGYKVSGGLHGVGASVVNALSTELDVTVHRDGKIHRQTYKRGVPVTDLEIIG ETDHTGTTTHFVPDPEIFSETTEYDYDLLANRVRELAFLTKGVNITIEDKREGQERKN EYHYEGGIKSYVEYLNRSKEVVHEEPIYIEGEKDGITVEVALQYNDSYTSNIYSFTNN INTYEGGTHEAGFKTGLTRVINDYARKKGLIKENDPNLSGDDVREGLTAIISIKHPDP QFEGQTKTKLGNSEARTITDTLFSTAMETFMLENPDAAKKIVDKGLMAARARMAAKKA RELTRRKSALEISNLPGKLADCSSKDPSISELYIVEGDSAGGSAKQGRDRHFQAILPL RGKILNVEKARLDKILSNNEVRSMITALGTGIGEDFNLEKARYHKVVIMTDADVDGAH IRTLLLTFFYRYMRQIIENGYVYIAQPPLYKVQQGKRVEYAYNDKELEELLKTLPQTP KPGLQRYKGLGEMNATQLWETTMDPSSRTLLQVTLEDAMDADETFEMLMGDKVEPRRN FIEANARYVKNLDI*" /label="gyrB CDS" gene 4458..6374 /gene="gyrB" /locus_tag="BSU_00060" /old_locus_tag="BSU00060" /label="gyrB gene" promotor_-10 complement(6003..6021) /Source="Nicolas_upshift_promotors" /id="U6" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1200 /SigmaFactorBS="cggcggctgcgcaatgtacacgtAGCCATtttcgataatttg gcGCATATATCTGTAAAAGAAcgttaacagcagtgttctgatgtgcgcgccgtcaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(6005) /Source="Nicolas_upshifts" /id="U6" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1200 /SigmaFactorBS="cggcggctgcgcaatgtacacgtAGCCATtttcgataatttg gcGCATATATCTGTAAAAGAAcgttaacagcagtgttctgatgtgcgcgccgtcaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(6037..6042) /Source="Nicolas_upshift_promotors" /id="U6" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1200 /SigmaFactorBS="cggcggctgcgcaatgtacacgtAGCCATtttcgataatttg gcGCATATATCTGTAAAAGAAcgttaacagcagtgttctgatgtgcgcgccgtcaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 6375..6584 /Source="Nicolas_S_feature" /locus_tag="new_6784_6993" /HighExp="Cold, H2O2, G180, Oxctl, G135, G150, Sw, dia15, LBGexp, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="SigA" /TUlongPSig=1 /label="S6" CDS 6585..9050 /gene="gyrA" /locus_tag="BSU_00070" /old_locus_tag="BSU00070" /EC_number="5.99.1.3" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12682299, 12767818, 17320901, 27557712" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 12767818, 17320901, 27557712; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA gyrase (subunit A)" /protein_id="NP_387888.1" /db_xref="EnsemblGenomes-Gn:BSU00070" /db_xref="EnsemblGenomes-Tr:CAB11783" /db_xref="GOA:P05653" /db_xref="InterPro:IPR002205" /db_xref="InterPro:IPR005743" /db_xref="InterPro:IPR006691" /db_xref="InterPro:IPR013757" /db_xref="InterPro:IPR013758" /db_xref="InterPro:IPR013760" /db_xref="InterPro:IPR024946" /db_xref="InterPro:IPR035516" /db_xref="PDB:4DDQ" /db_xref="SubtiList:BG10071" /db_xref="UniProtKB/Swiss-Prot:P05653" /translation="MSEQNTPQVREINISQEMRTSFLDYAMSVIVSRALPDVRDGLKP VHRRILYAMNDLGMTSDKPYKKSARIVGEVIGKYHPHGDSAVYESMVRMAQDFNYRYM LVDGHGNFGSVDGDSAAAMRYTEARMSKISMEILRDITKDTIDYQDNYDGSEREPVVM PSRFPNLLVNGAAGIAVGMATNIPPHQLGEIIDGVLAVSENPDITIPELMEVIPGPDF PTAGQILGRSGIRKAYESGRGSITIRAKAEIEQTSSGKERIIVTELPYQVNKAKLIEK IADLVRDKKIEGITDLRDESDRTGMRIVIEIRRDANANVILNNLYKQTALQTSFGINL LALVDGQPKVLTLKQCLEHYLDHQKVVIRRRTAYELRKAEARAHILEGLRVALDHLDA VISLIRNSQTAEIARTGLIEQFSLTEKQAQAILDMRLQRLTGLEREKIEEEYQSLVKL IAELKDILANEYKVLEIIREELTEIKERFNDERRTEIVTSGLETIEDEDLIERENIVV TLTHNGYVKRLPASTYRSQKRGGKGVQGMGTNEDDFVEHLISTSTHDTILFFSNKGKV YRAKGYEIPEYGRTAKGIPIINLLEVEKGEWINAIIPVTEFNAELYLFFTTKHGVSKR TSLSQFANIRNNGLIALSLREDDELMGVRLTDGTKQIIIGTKNGLLIRFPETDVREMG RTAAGVKGITLTDDDVVVGMEILEEESHVLIVTEKGYGKRTPAEEYRTQSRGGKGLKT AKITENNGQLVAVKATKGEEDLMIITASGVLIRMDINDISITGRVTQGVRLIRMAEEE HVATVALVEKNEEDENEEEQEEV*" /label="gyrA CDS" gene 6585..9050 /gene="gyrA" /locus_tag="BSU_00070" /old_locus_tag="BSU00070" /label="gyrA gene" promotor_-35 8964..8967 /Source="Nicolas_upshift_promotors" /id="U7" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.418581418581419" /psig="0.9000999000999" /xcortree=2642 /SigmaFactorBS="tggacatcaatgatatctccatcaccggacgtgtcactcaag gtgtgcgtctcatcagaATGGcagaagaagagcatgtTGCTACAGTAGCTTTAGTtga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 8965 /Source="Nicolas_upshifts" /id="U7" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.418581418581419" /psig="0.9000999000999" /xcortree=2642 /SigmaFactorBS="tggacatcaatgatatctccatcaccggacgtgtcactcaag gtgtgcgtctcatcagaATGGcagaagaagagcatgtTGCTACAGTAGCTTTAGTtga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 8984..9001 /Source="Nicolas_upshift_promotors" /id="U7" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.418581418581419" /psig="0.9000999000999" /xcortree=2642 /SigmaFactorBS="tggacatcaatgatatctccatcaccggacgtgtcactcaag gtgtgcgtctcatcagaATGGcagaagaagagcatgtTGCTACAGTAGCTTTAGTtga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 9031 /Source="Nicolas_upshifts" /id="D2" /incds=0 /nref=251 /ntot=261 /MaxReadThrough="3.73971" /MaxDrop="8.1288" /score="33.5021066" /energy="-14.1" /TU="NA" /idTUdmin="U4" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 9095..9101 /Source="Nicolas_upshift_promotors" /id="U8" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2622 /SigmaFactorBS="cagctgaaatagctgcgcttttttgtgtcataaccCTTTACA gtcataaaaattaTGGTATAATCATTTCTGTTGtctttttaaagacacaagcatgacc a" /listShort="S7, rrnO-16S" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 9115..9134 /Source="Nicolas_upshift_promotors" /id="U8" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2622 /SigmaFactorBS="cagctgaaatagctgcgcttttttgtgtcataaccCTTTACA gtcataaaaattaTGGTATAATCATTTCTGTTGtctttttaaagacacaagcatgacc a" /listShort="S7, rrnO-16S" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 9120..9205 /Source="Nicolas_S_feature" /locus_tag="new_9529_9614" /HighExp="LBGstat, H2O2, Paraq, Oxctl, UNK1, LBGexp, LPhT, MG-0.2, MG 25, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S7" upshifts 9120 /Source="Nicolas_upshifts" /id="U8" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2622 /SigmaFactorBS="cagctgaaatagctgcgcttttttgtgtcataaccCTTTACA gtcataaaaattaTGGTATAATCATTTCTGTTGtctttttaaagacacaagcatgacc a" /listShort="S7, rrnO-16S" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 9191..9198 /Source="Nicolas_upshift_promotors" /id="U9" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.889110889110889" /psig=1 /xcortree=2634 /SigmaFactorBS="cacaagcatgaccattatgactagtaaaaactttttcaaaaa agTATTGACCtagttaactaaaaaTGTTACTATTAAGTAGTCGCtttgagagaagcac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 9207 /Source="Nicolas_upshifts" /id="U9" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.889110889110889" /psig=1 /xcortree=2634 /SigmaFactorBS="cacaagcatgaccattatgactagtaaaaactttttcaaaaa agTATTGACCtagttaactaaaaaTGTTACTATTAAGTAGTCGCtttgagagaagcac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 9213..9232 /Source="Nicolas_upshift_promotors" /id="U9" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.889110889110889" /psig=1 /xcortree=2634 /SigmaFactorBS="cacaagcatgaccattatgactagtaaaaactttttcaaaaa agTATTGACCtagttaactaaaaaTGTTACTATTAAGTAGTCGCtttgagagaagcac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" rRNA 9401..10955 /gene="rrnO-16S" /locus_tag="BSU_rRNA_1" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnO-16S rRNA" gene 9401..10955 /gene="rrnO-16S" /locus_tag="BSU_rRNA_1" /label="rrnO-16S gene" tRNA 11055..11131 /gene="trnO-Ile" /locus_tag="BSU_tRNA_5" /product="tRNA-Ile" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnO-Ile tRNA" gene 11055..11131 /gene="trnO-Ile" /locus_tag="BSU_tRNA_5" /label="trnO-Ile gene" tRNA 11143..11218 /gene="trnO-Ala" /locus_tag="BSU_tRNA_6" /product="tRNA-Ala" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ala(UGC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnO-Ala tRNA" gene 11143..11218 /gene="trnO-Ala" /locus_tag="BSU_tRNA_6" /label="trnO-Ala gene" rRNA 11300..14227 /gene="rrnO-23S" /locus_tag="BSU_rRNA_2" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnO-23S rRNA" gene 11300..14227 /gene="rrnO-23S" /locus_tag="BSU_rRNA_2" /label="rrnO-23S gene" rRNA 14283..14401 /gene="rrnO-5S" /locus_tag="BSU_rRNA_3" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnO-5S rRNA" gene 14283..14401 /gene="rrnO-5S" /locus_tag="BSU_rRNA_3" /label="rrnO-5S gene" S_feature 14402..15459 /Source="Nicolas_S_feature" /locus_tag="new_14811_15868" /HighExp="G180, T0.0H, T0.30H, G135, T-0.40H, LBGstat, Cold, Paraq, C30, Oxctl" /AntisenseName="yaaC" /AntisenseCor="-4.5985764709218099E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S8" CDS complement(14438..15385) /gene="yaaC" /locus_tag="BSU_00080" /old_locus_tag="BSU00080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22333191" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_387889.1" /db_xref="EnsemblGenomes-Gn:BSU00080" /db_xref="EnsemblGenomes-Tr:CAB11784" /db_xref="InterPro:IPR026988" /db_xref="SubtiList:BG10072" /db_xref="UniProtKB/Swiss-Prot:P37526" /translation="MTYHEWKDLALFYSVESTQKFLEKVYILNGINDAKKNSFKNSER FIYFLKHAESFYKQAAYSPLEIKPILLFYGMAQLIKACLITRDPHYPSHTSVLAHGVT TRKRKKQNYCFSDDEVKIQRNGLCVHFMKHLFGQSDIVDERYTMKKLLMAIPELSDIF YFQQKERFMTKVEKDKNEIFVPEEVVINYKMSDSRFAEYMSHHYQWSFTKKNEHGLLF EISPQDKEPWTSTSLLFDMEKNQYYIPSQREQFLRLPEMTIHYLILYNVGMIARYETE WWYELLTQHISDDYVLIQQFLLVSEKKFPKYASQFLLHF*" /label="yaaC CDS" gene complement(14438..15385) /gene="yaaC" /locus_tag="BSU_00080" /old_locus_tag="BSU00080" /label="yaaC gene" promotor_-35 15438..15445 /Source="Nicolas_upshift_promotors" /id="U10" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.721278721278721" /psig=1 /xcortree=2668 /SigmaFactorBS="ctttccgttatctaaatatttcaactctttcccgcttCCTTG ACAtgctcttggctagtTGATAATCTACATATAATATtttgccgaaaagagggggatt t" /listShort="guaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 15460..15479 /Source="Nicolas_upshift_promotors" /id="U10" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.721278721278721" /psig=1 /xcortree=2668 /SigmaFactorBS="ctttccgttatctaaatatttcaactctttcccgcttCCTTG ACAtgctcttggctagtTGATAATCTACATATAATATtttgccgaaaagagggggatt t" /listShort="guaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 15461 /Source="Nicolas_upshifts" /id="U10" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.721278721278721" /psig=1 /xcortree=2668 /SigmaFactorBS="ctttccgttatctaaatatttcaactctttcccgcttCCTTG ACAtgctcttggctagtTGATAATCTACATATAATATtttgccgaaaagagggggatt t" /listShort="guaB" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(15466) /Source="Nicolas_upshifts" /id="U11" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.89010989010989" /psig="0.89010989010989" /xcortree=947 /SigmaFactorBS="tgaaaatttactttcccacaTTAGTAAatccccctcttttCG GCAAAATATTatatgtagattatcaactagccaagagcatgtcaaggaagcgggaaag a" /listShort="yaaC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(15475..15486) /Source="Nicolas_upshift_promotors" /id="U11" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.89010989010989" /psig="0.89010989010989" /xcortree=947 /SigmaFactorBS="tgaaaatttactttcccacaTTAGTAAatccccctcttttCG GCAAAATATTatatgtagattatcaactagccaagagcatgtcaaggaagcgggaaag a" /listShort="yaaC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(15500..15506) /Source="Nicolas_upshift_promotors" /id="U11" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.89010989010989" /psig="0.89010989010989" /xcortree=947 /SigmaFactorBS="tgaaaatttactttcccacaTTAGTAAatccccctcttttCG GCAAAATATTatatgtagattatcaactagccaagagcatgtcaaggaagcgggaaag a" /listShort="yaaC" /GFF_Attribute="listLong" /label="promotor_-35" CDS 15506..16972 /gene="guaB" /locus_tag="BSU_00090" /old_locus_tag="BSU00090" /EC_number="1.1.1.205" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 1722815, 17611193, 1979163, 3125411, 8917437" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 1722815, 17611193, 1979163, 3125411, 8917437; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="inosine-monophosphate dehydrogenase" /protein_id="NP_387890.1" /db_xref="EnsemblGenomes-Gn:BSU00090" /db_xref="EnsemblGenomes-Tr:CAB11785" /db_xref="GOA:P21879" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR001093" /db_xref="InterPro:IPR005990" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR015875" /db_xref="SubtiList:BG10073" /db_xref="UniProtKB/Swiss-Prot:P21879" /translation="MWESKFSKEGLTFDDVLLVPAKSEVLPRDVDLSVELTKTLKLNI PVISAGMDTVTESAMAIAMARQGGLGIIHKNMSIEQQAEQVDKVKRSERGVITNPFFL TPDHQVFDAEHLMGKYRISGVPIVNNEEDQKLVGIITNRDLRFISDYSMKISDVMTKE ELVTASVGTTLDEAEKILQKHKIEKLPLVDDQNKLKGLITIKDIEKVIEFPNSSKDIH GRLIVGAAVGVTGDTMTRVKKLVEANVDVIVIDTAHGHSQGVLNTVTKIRETYPELNI IAGNVATAEATRALIEAGADVVKVGIGPGSICTTRVVAGVGVPQITAIYDCATEARKH GKTIIADGGIKFSGDITKALAAGGHAVMLGSLLAGTSESPGETEIYQGRRFKVYRGMG SVAAMEKGSKDRYFQEENKKFVPEGIEGRTPYKGPVEETVYQLVGGLRSGMGYCGSKD LRALREEAQFIRMTGAGLRESHPHDVQITKESPNYTIS*" /label="guaB CDS" gene 15506..16972 /gene="guaB" /locus_tag="BSU_00090" /old_locus_tag="BSU00090" /label="guaB gene" downshifts complement(15510) /Source="Nicolas_upshifts" /id="D3" /incds=0 /nref=33 /ntot=102 /MaxReadThrough="1.81989" /MaxDrop="4.44626" /score="-6.76739893" /energy="-12.2" /TU="NA" /idTUdmin="U12" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_no_box complement(15536..15636) /Source="Nicolas_upshift_promotors" /id="U12" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.922077922077922" /psig="0.016983016983017" /xcortree=82 /SigmaFactorBS="atatttagctttaacgtttttgtaagttctacagataaatcc acatcacgcggaagtacctcagactttgctggtacaagcagcacatcgtcgaacgtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(15576) /Source="Nicolas_upshifts" /id="U12" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.922077922077922" /psig="0.016983016983017" /xcortree=82 /SigmaFactorBS="atatttagctttaacgtttttgtaagttctacagataaatcc acatcacgcggaagtacctcagactttgctggtacaagcagcacatcgtcgaacgtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(16829..17424) /Source="Nicolas_S_feature" /locus_tag="new_17238_17833_c" /HighExp="Etha, Gly, C30, Salt, S8, S6, HiTm, S7, Sw, C90" /AntisenseName="dacA" /AntisenseCor="-0.39306815699287101" /AntisenseRegPval="-10.6" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S9" downshifts 16960 /Source="Nicolas_upshifts" /id="D4" /incds=0 /nref=243 /ntot=277 /MaxReadThrough="3.34899" /MaxDrop="7.78161" /score="26.7620012" /energy="-10.6" /TU="NA" /idTUdmin="U10" /TUdmin="-14" /isTUend="TRUE" /label="downshifts" promotor_-35 17018..17022 /Source="Nicolas_upshift_promotors" /id="U13" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.948051948051948" /psig=1 /xcortree=2602 /SigmaFactorBS="aaattaaaaacatttgacagggtctctgactctgTCTATttt ttttatactgatTATGATAAAATTTATACTGTtgtgcattgaaaatgtccttaacggc t" /listShort="S10, dacA, S11, S12, pdxS, pdxT, NA, serS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 17038..17057 /Source="Nicolas_upshift_promotors" /id="U13" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.948051948051948" /psig=1 /xcortree=2602 /SigmaFactorBS="aaattaaaaacatttgacagggtctctgactctgTCTATttt ttttatactgatTATGATAAAATTTATACTGTtgtgcattgaaaatgtccttaacggc t" /listShort="S10, dacA, S11, S12, pdxS, pdxT, NA, serS" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 17044..17124 /Source="Nicolas_S_feature" /locus_tag="new_17453_17533" /HighExp="C30, LBGstat, G180, G150, LBGexp, G135, Lbexp, Oxctl, dia0, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S10" upshifts 17044 /Source="Nicolas_upshifts" /id="U13" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.948051948051948" /psig=1 /xcortree=2602 /SigmaFactorBS="aaattaaaaacatttgacagggtctctgactctgTCTATttt ttttatactgatTATGATAAAATTTATACTGTtgtgcattgaaaatgtccttaacggc t" /listShort="S10, dacA, S11, S12, pdxS, pdxT, NA, serS" /GFF_Attribute="listLong" /label="upshifts" CDS 17125..18456 /gene="dacA" /locus_tag="BSU_00100" /old_locus_tag="BSU00100" /EC_number="3.4.16.4" /experiment="publication(s) with functional evidences, PMID:8370539, 9864321, 10383963, 21378199" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8370539, 9864321, 10383963, 21378199; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 5)" /protein_id="NP_387891.1" /db_xref="EnsemblGenomes-Gn:BSU00100" /db_xref="EnsemblGenomes-Tr:CAB11786" /db_xref="GOA:P08750" /db_xref="InterPro:IPR001967" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR012907" /db_xref="InterPro:IPR015956" /db_xref="InterPro:IPR018044" /db_xref="InterPro:IPR037167" /db_xref="SubtiList:BG10074" /db_xref="UniProtKB/Swiss-Prot:P08750" /translation="MNIKKCKQLLMSLVVLTLAVTCLAPMSKAKAASDPIDINASAAI MIEASSGKILYSKNADKRLPIASMTKMMTEYLLLEAIDQGKVKWDQTYTPDDYVYEIS QDNSLSNVPLRKDGKYTVKELYQATAIYSANAAAIAIAEIVAGSETKFVEKMNAKAKE LGLTDYKFVNATGLENKDLHGHQPEGTSVNEESEVSAKDMAVLADHLITDYPEILETS SIAKTKFREGTDDEMDMPNWNFMLKGLVSEYKKATVDGLKTGSTDSAGSCFTGTAERN GMRVITVVLNAKGNLHTGRFDETKKMFDYAFDNFSMKEIYAEGDQVKGHKTISVDKGK EKEVGIVTNKAFSLPVKNGEEKNYKAKVTLNKDNLTAPVKKGTKVGKLTAEYTGDEKD YGFLNSDLAGVDLVTKENVEKANWFVLTMRSIGGFFAGIWGSIVDTVTGWF*" /label="dacA CDS" gene 17125..18456 /gene="dacA" /locus_tag="BSU_00100" /old_locus_tag="BSU00100" /label="dacA gene" promotor_-10 complement(17413..17431) /Source="Nicolas_upshift_promotors" /id="U14" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=212 /SigmaFactorBS="tactgtgtatttcccgtctttccgaagaggaaCGTTTGAtaa gctgttatcttGGGAAATTTCATACACATAgtcatcaggcgtataggtttggtcccat t" /listShort="S9" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(17424) /Source="Nicolas_upshifts" /id="U14" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=212 /SigmaFactorBS="tactgtgtatttcccgtctttccgaagaggaaCGTTTGAtaa gctgttatcttGGGAAATTTCATACACATAgtcatcaggcgtataggtttggtcccat t" /listShort="S9" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(17446..17452) /Source="Nicolas_upshift_promotors" /id="U14" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=212 /SigmaFactorBS="tactgtgtatttcccgtctttccgaagaggaaCGTTTGAtaa gctgttatcttGGGAAATTTCATACACATAgtcatcaggcgtataggtttggtcccat t" /listShort="S9" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 18338 /Source="Nicolas_upshifts" /id="D5" /incds=1 /nref=1 /ntot=20 /MaxReadThrough="6.76335" /MaxDrop="2.1925" /score="26.7620012" /energy="-10.6" /TU="U13" /idTUdmin="U10" /TUdmin=1364 /isTUend="FALSE" /label="downshifts" S_feature 18457..18565 /Source="Nicolas_S_feature" /locus_tag="new_18866_18974" /HighExp="C30, MG 15, MG 10, MG-0.1, MG 25, BMM, ferm, Cold, MG 60, MG-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S11" promotor_-35 18535..18538 /Source="Nicolas_upshift_promotors" /id="U15" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.61038961038961" /psig="0.998001998001998" /xcortree=2311 /SigmaFactorBS="gaaaaaacccaatttttaataaaaaatgATTTtcaaagcgct aaaaACCGAATAAAATAGTATATAtgcatatgaattattggatttctaggatacaata a" /listShort="S12, pdxS, pdxT, NA, serS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 18553..18572 /Source="Nicolas_upshift_promotors" /id="U15" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.61038961038961" /psig="0.998001998001998" /xcortree=2311 /SigmaFactorBS="gaaaaaacccaatttttaataaaaaatgATTTtcaaagcgct aaaaACCGAATAAAATAGTATATAtgcatatgaattattggatttctaggatacaata a" /listShort="S12, pdxS, pdxT, NA, serS" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 18567..18652 /Source="Nicolas_S_feature" /locus_tag="new_18976_19061" /HighExp="BMM, MG 25, SMM, MG 15, UNK1, MG 10, GM 150, MG-0.1, MG 150, MG 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S12" upshifts 18567 /Source="Nicolas_upshifts" /id="U15" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.61038961038961" /psig="0.998001998001998" /xcortree=2311 /SigmaFactorBS="gaaaaaacccaatttttaataaaaaatgATTTtcaaagcgct aaaaACCGAATAAAATAGTATATAtgcatatgaattattggatttctaggatacaata a" /listShort="S12, pdxS, pdxT, NA, serS" /GFF_Attribute="listLong" /label="upshifts" CDS 18653..19537 /gene="pdxS" /locus_tag="BSU_00110" /old_locus_tag="BSU00110" /EC_number="4.3.3.6" /EC_number="4.-.-.-" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:14762015, 15771487, 15911615, 16157873, 17144654" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14762015, 15771487, 15911615, 16157873, 17144654; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamine amidotransferase for pyridoxal phosphate synthesis; pyridoxal 5'-phosphate synthase complex, synthase subunit" /protein_id="NP_387892.1" /db_xref="EnsemblGenomes-Gn:BSU00110" /db_xref="EnsemblGenomes-Tr:CAB11787" /db_xref="GOA:P37527" /db_xref="InterPro:IPR001852" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR033755" /db_xref="PDB:2NV1" /db_xref="PDB:2NV2" /db_xref="SubtiList:BG10075" /db_xref="UniProtKB/Swiss-Prot:P37527" /translation="MAQTGTERVKRGMAEMQKGGVIMDVINAEQAKIAEEAGAVAVMA LERVPADIRAAGGVARMADPTIVEEVMNAVSIPVMAKARIGHIVEARVLEAMGVDYID ESEVLTPADEEFHLNKNEYTVPFVCGCRDLGEATRRIAEGASMLRTKGEPGTGNIVEA VRHMRKVNAQVRKVVAMSEDELMTEAKNLGAPYELLLQIKKDGKLPVVNFAAGGVATP ADAALMMQLGADGVFVGSGIFKSDNPAKFAKAIVEATTHFTDYKLIAELSKELGTAMK GIEISNLLPEQRMQERGW*" /label="pdxS CDS" gene 18653..19537 /gene="pdxS" /locus_tag="BSU_00110" /old_locus_tag="BSU00110" /label="pdxS gene" S_feature complement(18785..19514) /Source="Nicolas_S_feature" /locus_tag="new_19194_19923_c" /HighExp="S6, S8, S7, S5, S4, C30, S3, BT, C90, Gly" /AntisenseName="pdxS" /AntisenseCor="-0.65390240445415004" /AntisenseRegPval="-33.5" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S13" promotor_-10 complement(19502..19520) /Source="Nicolas_upshift_promotors" /id="U16" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1195 /SigmaFactorBS="cacctattgttaacatgtcagcagcgctcctatGTTCTTacc agccgcgttcttGCATACGCTGTTCTGGAAGtaagtttgagatttcaatccctttcat t" /listShort="S13" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(19514) /Source="Nicolas_upshifts" /id="U16" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1195 /SigmaFactorBS="cacctattgttaacatgtcagcagcgctcctatGTTCTTacc agccgcgttcttGCATACGCTGTTCTGGAAGtaagtttgagatttcaatccctttcat t" /listShort="S13" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(19536..19541) /Source="Nicolas_upshift_promotors" /id="U16" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1195 /SigmaFactorBS="cacctattgttaacatgtcagcagcgctcctatGTTCTTacc agccgcgttcttGCATACGCTGTTCTGGAAGtaagtttgagatttcaatccctttcat t" /listShort="S13" /GFF_Attribute="listLong" /label="promotor_-35" CDS 19559..20149 /gene="pdxT" /locus_tag="BSU_00120" /old_locus_tag="BSU00120" /EC_number="3.5.1.2" /EC_number="4.3.3.6" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:14585832, 14762015, 15771487, 17144654, 18271580, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14585832, 14762015, 15771487, 17144654, 18271580, 26735940; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="glutamine amidotransferase for pyridoxal phosphate synthesis; pyridoxal 5'-phosphate synthase complex, glutamine amidotransferase subunit PdxT" /protein_id="NP_387893.1" /db_xref="EnsemblGenomes-Gn:BSU00120" /db_xref="EnsemblGenomes-Tr:CAB11788" /db_xref="GOA:P37528" /db_xref="InterPro:IPR002161" /db_xref="InterPro:IPR021196" /db_xref="InterPro:IPR029062" /db_xref="PDB:1R9G" /db_xref="PDB:2NV0" /db_xref="PDB:2NV2" /db_xref="SubtiList:BG10076" /db_xref="UniProtKB/Swiss-Prot:P37528" /translation="MLTIGVLGLQGAVREHIHAIEACGAAGLVVKRPEQLNEVDGLIL PGGESTTMRRLIDTYQFMEPLREFAAQGKPMFGTCAGLIILAKEIAGSDNPHLGLLNV VVERNSFGRQVDSFEADLTIKGLDEPFTGVFIRAPHILEAGENVEVLSEHNGRIVAAK QGQFLGCSFHPELTEDHRVTQLFVEMVEEYKQKALV*" /label="pdxT CDS" gene 19559..20149 /gene="pdxT" /locus_tag="BSU_00120" /old_locus_tag="BSU00120" /label="pdxT gene" misc_RNA 20202..20414 /gene="tboS" /locus_tag="BSU_misc_RNA_1" /product="T-box riboswitch specific of serine tRNA ligase" /experiment="publication(s) with functional evidences, PMID:1317842, 9098041, 12165569, 12547201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1317842, 9098041, 12165569, 12547201; Product type n: RNA" /function="16.3: Control" /label="tboS RNA" gene 20202..20414 /gene="tboS" /locus_tag="BSU_misc_RNA_1" /label="tboS gene" downshifts 20379 /Source="Nicolas_upshifts" /id="D6" /incds=0 /nref=9 /ntot=80 /MaxReadThrough="7.14793" /MaxDrop="4.37654" /score="41.1243331" /energy="-23.3" /TU="U13,U15" /idTUdmin="U13" /TUdmin="-1347" /isTUend="FALSE" /label="downshifts" CDS 20471..21748 /gene="serS" /locus_tag="BSU_00130" /old_locus_tag="BSU00130" /EC_number="6.1.1.11" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10546897, 12682299, 14732487" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10546897, 12682299, 14732487; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="seryl-tRNA synthetase" /protein_id="NP_387894.1" /db_xref="EnsemblGenomes-Gn:BSU00130" /db_xref="EnsemblGenomes-Tr:CAB11789" /db_xref="GOA:P37464" /db_xref="InterPro:IPR002314" /db_xref="InterPro:IPR002317" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR010978" /db_xref="InterPro:IPR015866" /db_xref="InterPro:IPR033729" /db_xref="SubtiList:BG10077" /db_xref="UniProtKB/Swiss-Prot:P37464" /translation="MLDTKMLRANFQEIKAKLVHKGEDLTDFDKFEALDDRRRELIGK VEELKGKRNEVSQQVAVLKREKKDADHIIKEMREVGEEIKKLDEELRTVEAELDTILL SIPNIPHESVPVGETEDDNVEVRKWGEKPSFAYEPKPHWDIADELGILDFERAAKVTG SRFVFYKGLGARLERALYNFMLDLHVDEYNYTEVIPPYMVNRASMTGTGQLPKFEEDA FKIREEDYFLIPTAEVPITNMHRDEILSGDSLPINYAAFSACFRSEAGSAGRDTRGLI RQHQFNKVELVKFVKPEDSYEELEKLTNQAERVLQLLELPYRVMSMCTGDLGFTAAKK YDIEVWIPSQDTYREISSCSNFEAFQARRANIRFRREAKGKPEHVHTLNGSGLAVGRT VAAILENYQQEDGSVVIPKVLRPYMGNREVMKP*" /label="serS CDS" gene 20471..21748 /gene="serS" /locus_tag="BSU_00130" /old_locus_tag="BSU00130" /label="serS gene" downshifts 21726 /Source="Nicolas_upshifts" /id="D7" /incds=0 /nref=234 /ntot=255 /MaxReadThrough="0.83411" /MaxDrop="7.38039" /score="17.6549558" /energy="-13.3" /TU="NA" /idTUdmin="U13" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 21837..21844 /Source="Nicolas_upshift_promotors" /id="U17" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=2413 /SigmaFactorBS="cggcattttcataaaaacaaaaaaagtttttaaaaatgCTTG ACCAcacgagaacatacgTGATATAGTTAGTCTTGTCGatacggaggaatacccaagt c" /listShort="trnSL-Ser1, S14, S15" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 21859..21878 /Source="Nicolas_upshift_promotors" /id="U17" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=2413 /SigmaFactorBS="cggcattttcataaaaacaaaaaaagtttttaaaaatgCTTG ACCAcacgagaacatacgTGATATAGTTAGTCTTGTCGatacggaggaatacccaagt c" /listShort="trnSL-Ser1, S14, S15" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 21859 /Source="Nicolas_upshifts" /id="U17" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=2413 /SigmaFactorBS="cggcattttcataaaaacaaaaaaagtttttaaaaatgCTTG ACCAcacgagaacatacgTGATATAGTTAGTCTTGTCGatacggaggaatacccaagt c" /listShort="trnSL-Ser1, S14, S15" /GFF_Attribute="listLong" /label="upshifts" tRNA 21883..21975 /gene="trnSL-Ser1" /locus_tag="BSU_tRNA_7" /product="tRNA-Ser" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ser(UGA); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Ser1 tRNA" gene 21883..21975 /gene="trnSL-Ser1" /locus_tag="BSU_tRNA_7" /label="trnSL-Ser1 gene" downshifts 21998 /Source="Nicolas_upshifts" /id="D8" /incds=0 /nref=168 /ntot=196 /MaxReadThrough="5.02201" /MaxDrop="8.36635" /score="29.7083093" /energy="-12.4" /TU="U17" /idTUdmin="U13" /TUdmin=272 /isTUend="FALSE" /label="downshifts" S_feature 22043..22120 /Source="Nicolas_S_feature" /locus_tag="new_22452_22529" /HighExp="Cold, H2O2, G180, Paraq, Oxctl, C30, G150, G135, BMM, Heat" /AntisenseName="dck" /AntisenseCor="0.61769771609764101" /AntisenseRegPval="-29" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S14" CDS complement(22087..22740) /gene="dck" /locus_tag="BSU_00140" /old_locus_tag="BSU00140" /EC_number="2.7.1.76" /EC_number="2.7.1.74" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:6251049, 11078735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6251049, 11078735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="deoxyadenosine/deoxycytidine kinase" /protein_id="NP_387895.1" /db_xref="EnsemblGenomes-Gn:BSU00140" /db_xref="EnsemblGenomes-Tr:CAB11790" /db_xref="GOA:P37529" /db_xref="InterPro:IPR002624" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031314" /db_xref="SubtiList:BG10078" /db_xref="UniProtKB/Swiss-Prot:P37529" /translation="MKEHHIPKNSIITVAGTVGVGKSTLTKTLAKRLGFKTSLEEVDH NPYLEKFYHDFERWSFHLQIYFLAERFKEQKTIFEAGGGFVQDRSIYEDTGIFAKMHA DKGTMSKVDYKTYTSLFEAMVMTPYFPHPDVLIYLEGDLENILNRIEQRGREMELQTS RSYWEEMHTRYENWISGFNACPVLKLRIEDYDLLNDENSIENIVDQIASVIHDNQKK* " /label="dck CDS" gene complement(22087..22740) /gene="dck" /locus_tag="BSU_00140" /old_locus_tag="BSU00140" /label="dck gene" promotor_-35 22106..22112 /Source="Nicolas_upshift_promotors" /id="U18" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.474525474525474" /psig="0.474525474525474" /xcortree=1189 /SigmaFactorBS="agaaaaagtgaatctcgactgagattcactttttttgattat caTGAATAActgaagcaatttgATCTACAATATTttcaatcgagttttcgtcgttcag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(22111) /Source="Nicolas_upshifts" /id="D9" /incds=0 /nref=88 /ntot=213 /MaxReadThrough="1.96668" /MaxDrop="4.49235" /score="14.5948578" /energy="-11" /TU="NA" /idTUdmin="U19" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" S_feature 22122..22758 /Source="Nicolas_S_feature" /locus_tag="new_22531_23167" /HighExp="G180, G135, Cold, C30, Paraq, H2O2, Oxctl, G150, S5, S6" /AntisenseName="dck" /AntisenseCor="0.15155468296621499" /AntisenseRegPval="-1.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S15" upshifts 22122 /Source="Nicolas_upshifts" /id="U18" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.474525474525474" /psig="0.474525474525474" /xcortree=1189 /SigmaFactorBS="agaaaaagtgaatctcgactgagattcactttttttgattat caTGAATAActgaagcaatttgATCTACAATATTttcaatcgagttttcgtcgttcag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 22126..22137 /Source="Nicolas_upshift_promotors" /id="U18" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.474525474525474" /psig="0.474525474525474" /xcortree=1189 /SigmaFactorBS="agaaaaagtgaatctcgactgagattcactttttttgattat caTGAATAActgaagcaatttgATCTACAATATTttcaatcgagttttcgtcgttcag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(22737..23360) /gene="dgk" /locus_tag="BSU_00150" /old_locus_tag="BSU00150" /EC_number="2.7.1.113" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11078735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11078735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="deoxyguanosine kinase" /protein_id="NP_387896.1" /db_xref="EnsemblGenomes-Gn:BSU00150" /db_xref="EnsemblGenomes-Tr:CAB11791" /db_xref="GOA:P37530" /db_xref="InterPro:IPR002624" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031314" /db_xref="SubtiList:BG10079" /db_xref="UniProtKB/Swiss-Prot:P37530" /translation="MNTAPFIAIEGPIGAGKTTLATMLSQKFGFPMINEIVEDNPYLD KFYDNIKEWSFQLEMFFLCHRYKQLEDTSDHFLKKGQPVIADYHIYKNVIFAERTLSP HQLEKYKKIYHLLTDDLPKPNFIIYIKASLPTLLHRIEKRGRPFEKKIETSYLEQLIS DYEVAIKQLQEADPELTVLTVDGDSKDFVLNKSDFERIAAHVKELIV*" /label="dgk CDS" gene complement(22737..23360) /gene="dgk" /locus_tag="BSU_00150" /old_locus_tag="BSU00150" /label="dgk gene" promotor_-10 complement(23401..23420) /Source="Nicolas_upshift_promotors" /id="U19" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.948051948051948" /psig=1 /xcortree=2605 /SigmaFactorBS="gtcaaaaagacgtttcgataatttggaaacgtcttttttTCA TGggggcacccaagggtTGTGATACAATATGAAGGTCggtaactgacgcacgtttttc a" /listShort="dgk, dck" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(23419) /Source="Nicolas_upshifts" /id="U19" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.948051948051948" /psig=1 /xcortree=2605 /SigmaFactorBS="gtcaaaaagacgtttcgataatttggaaacgtcttttttTCA TGggggcacccaagggtTGTGATACAATATGAAGGTCggtaactgacgcacgtttttc a" /listShort="dgk, dck" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(23436..23440) /Source="Nicolas_upshift_promotors" /id="U19" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.948051948051948" /psig=1 /xcortree=2605 /SigmaFactorBS="gtcaaaaagacgtttcgataatttggaaacgtcttttttTCA TGggggcacccaagggtTGTGATACAATATGAAGGTCggtaactgacgcacgtttttc a" /listShort="dgk, dck" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(23459..24742) /gene="sleL" /locus_tag="BSU_00160" /old_locus_tag="BSU00160" /EC_number="3.2.1.-" /function="16.8: Protect" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11011148, 11737650, 12177332, 10419957, 18456807, 18835992, 19933362, 28333204; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore peptidoglycan N-acetylglucosaminidase" /protein_id="NP_387897.1" /db_xref="EnsemblGenomes-Gn:BSU00160" /db_xref="EnsemblGenomes-Tr:CAB11792" /db_xref="GOA:P37531" /db_xref="InterPro:IPR001223" /db_xref="InterPro:IPR011583" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG10080" /db_xref="UniProtKB/Swiss-Prot:P37531" /translation="MVKQGDTLSAIASQYRTTTNDITETNEIPNPDSLVVGQTIVIPI AGQFYDVKRGDTLTSIARQFNTTAAELARVNRIQLNTVLQIGFRLYIPPAPKRDIESN AYLEPRGNQVSENLQQAAREASPYLTYLGAFSFQAQRNGTLVAPPLTNLRSITESQNT TLMMIITNLENQAFSDELGRILLNDETVKRRLLNEIVENARRYGFRDIHFDFEYLRPQ DREAYNQFLREARDLFHREGLEISTALAPKTSATQQGRWYEAHDYRAHGEIVDFVVLM TYEWGYSGGPPQAVSPIGPVRDVIEYALTEMPANKIVMGQNLYGYDWTLPYTAGGTPA RAVSPQQAIVIADQNNASIQYDQTAQAPFFRYTDAENRRHEVWFEDARSIQAKFNLIK ELNLRGISYWKLGLSFPQNWLLLSDQFNVVKKTFR*" /label="sleL CDS" gene complement(23459..24742) /gene="sleL" /locus_tag="BSU_00160" /old_locus_tag="BSU00160" /label="sleL gene" downshifts complement(23496) /Source="Nicolas_upshifts" /id="D10" /incds=0 /nref=40 /ntot=61 /MaxReadThrough="1.17442" /MaxDrop="6.30997" /score="3.66560192" /energy="-8.4" /TU="NA" /idTUdmin="U20" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(24773..24791) /Source="Nicolas_upshift_promotors" /id="U20" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1152 /SigmaFactorBS="tttcgcagaaattacgacggaagaacaaattatagaaaaata AACATGatcagcgcttttcttTCATACATTGATAGCGATAtgaaaggaggcgtttttc a" /listShort="yaaH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(24794) /Source="Nicolas_upshifts" /id="U20" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1152 /SigmaFactorBS="tttcgcagaaattacgacggaagaacaaattatagaaaaata AACATGatcagcgcttttcttTCATACATTGATAGCGATAtgaaaggaggcgtttttc a" /listShort="yaaH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(24807..24812) /Source="Nicolas_upshift_promotors" /id="U20" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1152 /SigmaFactorBS="tttcgcagaaattacgacggaagaacaaattatagaaaaata AACATGatcagcgcttttcttTCATACATTGATAGCGATAtgaaaggaggcgtttttc a" /listShort="yaaH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(24812..25357) /gene="yaaI" /locus_tag="BSU_00170" /old_locus_tag="BSU00170" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 2521622; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative amidase (isochorismatase family)" /protein_id="NP_387898.1" /db_xref="EnsemblGenomes-Gn:BSU00170" /db_xref="EnsemblGenomes-Tr:CAB11793" /db_xref="GOA:P37532" /db_xref="InterPro:IPR000868" /db_xref="InterPro:IPR036380" /db_xref="SubtiList:BG10081" /db_xref="UniProtKB/Swiss-Prot:P37532" /translation="MSKADKALLIVDMINNFEFDMGETLAKKTEKIVPHILSLKEHAR QNEWPIIYINDHYGLWQADIKNIQQECTNERSKDIITKIAPVDADYFLIKPKHSAFYE TALHTLLTELQVRHIIITGIAGNICVLFTANDAYMREYSITIPKDCIASNSDEDNEFA LTMMENVLFAEITTEEQIIEK*" /label="yaaI CDS" gene complement(24812..25357) /gene="yaaI" /locus_tag="BSU_00170" /old_locus_tag="BSU00170" /label="yaaI gene" promotor_-35 25223..25227 /Source="Nicolas_upshift_promotors" /id="U21" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.78921078921079" /psig="0.99000999000999" /xcortree=1810 /SigmaFactorBS="taatgatcattgatgtaaataatcggccattcattTTGTCtc gcgtgctcctttAATGATAAAATATGAGGAACgattttttctgtttttttagcgaggg t" /listShort="S16, tadA, S17, scr, S18" /listLong="dnaX, yaaK, recR, yaaL, bofA, S19, rrnA-16S" /label="promotor_-35" promotor_-10 25242..25261 /Source="Nicolas_upshift_promotors" /id="U21" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.78921078921079" /psig="0.99000999000999" /xcortree=1810 /SigmaFactorBS="taatgatcattgatgtaaataatcggccattcattTTGTCtc gcgtgctcctttAATGATAAAATATGAGGAACgattttttctgtttttttagcgaggg t" /listShort="S16, tadA, S17, scr, S18" /listLong="dnaX, yaaK, recR, yaaL, bofA, S19, rrnA-16S" /label="promotor_-10" S_feature 25246..25442 /Source="Nicolas_S_feature" /locus_tag="new_25655_25851" /HighExp="Diami, dia5, H2O2, dia15, T0.30H, T-0.40H, HiOs, T-1.10H, Salt, T0.0H" /AntisenseName="yaaI" /AntisenseCor="9.6546810160837798E-2" /AntisenseRegPval="-0.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S16" upshifts 25248 /Source="Nicolas_upshifts" /id="U21" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.78921078921079" /psig="0.99000999000999" /xcortree=1810 /SigmaFactorBS="taatgatcattgatgtaaataatcggccattcattTTGTCtc gcgtgctcctttAATGATAAAATATGAGGAACgattttttctgtttttttagcgaggg t" /listShort="S16, tadA, S17, scr, S18" /listLong="dnaX, yaaK, recR, yaaL, bofA, S19, rrnA-16S" /label="upshifts" promotor_-10 complement(25382..25400) /Source="Nicolas_upshift_promotors" /id="U22" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=248 /SigmaFactorBS="aaagttcatcttgtgtcataaggataagctctcttttcaaAG TTTTTtcattgcctaaaaaGGCTACATATTAACTATAActgaaacggaaaggagactg t" /listShort="yaaI, yaaH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(25401) /Source="Nicolas_upshifts" /id="U22" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=248 /SigmaFactorBS="aaagttcatcttgtgtcataaggataagctctcttttcaaAG TTTTTtcattgcctaaaaaGGCTACATATTAACTATAActgaaacggaaaggagactg t" /listShort="yaaI, yaaH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(25415..25421) /Source="Nicolas_upshift_promotors" /id="U22" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=248 /SigmaFactorBS="aaagttcatcttgtgtcataaggataagctctcttttcaaAG TTTTTtcattgcctaaaaaGGCTACATATTAACTATAActgaaacggaaaggagactg t" /listShort="yaaI, yaaH" /GFF_Attribute="listLong" /label="promotor_-35" CDS 25443..25928 /gene="tadA" /locus_tag="BSU_00180" /old_locus_tag="BSU00180" /EC_number="3.5.4.33" /function="10.3: tRNA and rRNA base modification" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15677468, 16014871, 16415880, 16700551, 23658230; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA specific adenosine A34 deaminase" /protein_id="NP_387899.1" /db_xref="EnsemblGenomes-Gn:BSU00180" /db_xref="EnsemblGenomes-Tr:CAB11794" /db_xref="GOA:P21335" /db_xref="InterPro:IPR002125" /db_xref="InterPro:IPR016192" /db_xref="InterPro:IPR016193" /db_xref="InterPro:IPR028883" /db_xref="SubtiList:BG10082" /db_xref="UniProtKB/Swiss-Prot:P21335" /translation="MTQDELYMKEAIKEAKKAEEKGEVPIGAVLVINGEIIARAHNLR ETEQRSIAHAEMLVIDEACKALGTWRLEGATLYVTLEPCPMCAGAVVLSRVEKVVFGA FDPKGGCSGTLMNLLQEERFNHQAEVVSGVLEEECGGMLSAFFRELRKKKKAARKNLS E*" /label="tadA CDS" gene 25443..25928 /gene="tadA" /locus_tag="BSU_00180" /old_locus_tag="BSU00180" /label="tadA gene" promotor_-35 25932..25938 /Source="Nicolas_upshift_promotors" /id="U23" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.403596403596404" /psig="0.899100899100899" /xcortree=1436 /SigmaFactorBS="aacttgtctgaatagtacGGTTGCAatttttaggggaaACAG ATATACTTAAGTGTGCatcgtaatagatgcaacataaaatttgatatttattttgccg t" /listShort="S17, scr, S18" /listLong="dnaX, yaaK, recR, yaaL, bofA, S19, rrnA-16S" /label="promotor_-35" promotor_-10 25952..25971 /Source="Nicolas_upshift_promotors" /id="U23" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.403596403596404" /psig="0.899100899100899" /xcortree=1436 /SigmaFactorBS="aacttgtctgaatagtacGGTTGCAatttttaggggaaACAG ATATACTTAAGTGTGCatcgtaatagatgcaacataaaatttgatatttattttgccg t" /listShort="S17, scr, S18" /listLong="dnaX, yaaK, recR, yaaL, bofA, S19, rrnA-16S" /label="promotor_-10" misc_RNA 25970..26323 /gene="scr" /locus_tag="BSU_misc_RNA_2" /product="small cytoplasmic RNA (scRNA, 4.5S RNA), signal recognition particle-like (SRP) component" /experiment="publication(s) with functional evidences, PMID:1372600, 1689715" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1372600, 1689715" /label="scr RNA" gene 25970..26323 /gene="scr" /locus_tag="BSU_misc_RNA_2" /label="scr gene" S_feature 25974..26123 /Source="Nicolas_S_feature" /locus_tag="new_26383_26532" /HighExp="T1.0H, T5.0H, T1.30H, T3.30H, T3.0H, T2.30H, T4.0H, S8, T-1.10H, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.899, 0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S17" upshifts 25974 /Source="Nicolas_upshifts" /id="U23" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.403596403596404" /psig="0.899100899100899" /xcortree=1436 /SigmaFactorBS="aacttgtctgaatagtacGGTTGCAatttttaggggaaACAG ATATACTTAAGTGTGCatcgtaatagatgcaacataaaatttgatatttattttgccg t" /listShort="S17, scr, S18" /listLong="dnaX, yaaK, recR, yaaL, bofA, S19, rrnA-16S" /label="upshifts" S_feature 26227..26322 /Source="Nicolas_S_feature" /locus_tag="new_26636_26731" /HighExp="S8, Sw, B60, B36, T2.30H, T3.30H, T1.0H, BC, T4.0H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.899, 0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S18" downshifts 26279 /Source="Nicolas_upshifts" /id="D11" /incds=0 /nref=273 /ntot=278 /MaxReadThrough="4.46774" /MaxDrop="8.31255" /score="23.257527" /energy="-10.3" /TU="U21,U23" /idTUdmin="U21" /TUdmin="-89" /isTUend="FALSE" /label="downshifts" promotor_-35 26343..26346 /Source="Nicolas_upshift_promotors" /id="U24" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.863136863136863" /psig=1 /xcortree=2612 /SigmaFactorBS="attaggtgagttttttgttatgtaaaaagagctTTTGgaatc gaaacaaggTTCATGTATAATGGGAATGAtgaataacggaggagggcaaacccgtgag t" /listShort="dnaX, yaaK, recR, yaaL, bofA" /listLong="S19, rrnA-16S" /label="promotor_-35" promotor_-10 26361..26380 /Source="Nicolas_upshift_promotors" /id="U24" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.863136863136863" /psig=1 /xcortree=2612 /SigmaFactorBS="attaggtgagttttttgttatgtaaaaagagctTTTGgaatc gaaacaaggTTCATGTATAATGGGAATGAtgaataacggaggagggcaaacccgtgag t" /listShort="dnaX, yaaK, recR, yaaL, bofA" /listLong="S19, rrnA-16S" /label="promotor_-10" upshifts 26370 /Source="Nicolas_upshifts" /id="U24" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.863136863136863" /psig=1 /xcortree=2612 /SigmaFactorBS="attaggtgagttttttgttatgtaaaaagagctTTTGgaatc gaaacaaggTTCATGTATAATGGGAATGAtgaataacggaggagggcaaacccgtgag t" /listShort="dnaX, yaaK, recR, yaaL, bofA" /listLong="S19, rrnA-16S" /label="upshifts" CDS 26405..28096 /gene="dnaX" /locus_tag="BSU_00190" /old_locus_tag="BSU00190" /EC_number="2.7.7.7" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:9341154, 10844689, 12466528, 12974630, 14757052, 15927750, 25850333, 26786318" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9341154, 10844689, 12466528, 12974630, 14757052, 15927750, 25850333, 26786318; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase III subunit tau subunit" /protein_id="NP_387900.2" /db_xref="EnsemblGenomes-Gn:BSU00190" /db_xref="EnsemblGenomes-Tr:CAB11795" /db_xref="GOA:P09122" /db_xref="InterPro:IPR001270" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR008921" /db_xref="InterPro:IPR012763" /db_xref="InterPro:IPR022754" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10083" /db_xref="UniProtKB/Swiss-Prot:P09122" /translation="MSYQALYRVFRPQRFEDVVGQEHITKTLQNALLQKKFSHAYLFS GPRGTGKTSAAKIFAKAVNCEHAPVDEPCNECAACKGITNGSISDVIEIDAASNNGVD EIRDIRDKVKFAPSAVTYKVYIIDEVHMLSIGAFNALLKTLEEPPEHCIFILATTEPH KIPLTIISRCQRFDFKRITSQAIVGRMNKIVDAEQLQVEEGSLEIIASAADGGMRDAL SLLDQAISFSGDILKVEDALLITGAVSQLYIGKLAKSLHDKNVSDALETLNELLQQGK DPAKLIEDMIFYFRDMLLYKTAPGLEGVLEKVKVDETFRELSEQIPAQALYEMIDILN KSHQEMKWTNHPRIFFEVAVVKICQTSHQSAADLPEVDMLMKKIQQLEQEVERLKTTG IKAAAESPKKEAPRVPKGGKSNYKAPVGRIHEILKEATRPDLDLLRNSWGKLLAHLKQ QNKVSHAALLNDSEPVAAGSAAFVLKFKYEIHCKMVAEDNNGVRTNLEQILESMLGKR MDLIGVPEAQWGKIREEFLEDHQQENEGSNEPAEEDPLIAEAKKLVGADLIEIKD*" /label="dnaX CDS" gene 26405..28096 /gene="dnaX" /locus_tag="BSU_00190" /old_locus_tag="BSU00190" /label="dnaX gene" promotor_-35 27937..27944 /Source="Nicolas_upshift_promotors" /id="U25" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.761238761238761" /psig="0.999000999001" /xcortree=1923 /SigmaFactorBS="atgctcggaaaaagaatggatttGATTGGCGttccagaagca caaTGGGGTAAAATAAGAGAAGAatttttagaagatcatcagcaggaaaatgaaggat c" /listShort="yaaK, recR, yaaL, bofA" /listLong="S19, rrnA-16S" /label="promotor_-35" promotor_-10 27959..27978 /Source="Nicolas_upshift_promotors" /id="U25" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.761238761238761" /psig="0.999000999001" /xcortree=1923 /SigmaFactorBS="atgctcggaaaaagaatggatttGATTGGCGttccagaagca caaTGGGGTAAAATAAGAGAAGAatttttagaagatcatcagcaggaaaatgaaggat c" /listShort="yaaK, recR, yaaL, bofA" /listLong="S19, rrnA-16S" /label="promotor_-10" upshifts 27974 /Source="Nicolas_upshifts" /id="U25" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.761238761238761" /psig="0.999000999001" /xcortree=1923 /SigmaFactorBS="atgctcggaaaaagaatggatttGATTGGCGttccagaagca caaTGGGGTAAAATAAGAGAAGAatttttagaagatcatcagcaggaaaatgaaggat c" /listShort="yaaK, recR, yaaL, bofA" /listLong="S19, rrnA-16S" /label="upshifts" CDS 28120..28443 /gene="ebfC" /locus_tag="BSU_00200" /old_locus_tag="BSU00200" /function="16.9: Replicate" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16740939, 19208644, 19594923, 20639362, 22333191, 22544270; Product type f : factor" /codon_start=1 /transl_table=11 /product="nucleoid associated protein" /protein_id="NP_387901.1" /db_xref="EnsemblGenomes-Gn:BSU00200" /db_xref="EnsemblGenomes-Tr:CAB11796" /db_xref="GOA:P24281" /db_xref="InterPro:IPR004401" /db_xref="InterPro:IPR036894" /db_xref="SubtiList:BG10084" /db_xref="UniProtKB/Swiss-Prot:P24281" /translation="MRGGMGNMQKMMKQMQKMQKDMAKAQEELAEKVVEGTAGGGMVT VKANGQKEILDVIIKEEVVDPEDIDMLQDLVLAATNEALKKVDEITNETMGQFTKGMN MPGLF*" /label="ebfC CDS" gene 28120..28443 /gene="ebfC" /locus_tag="BSU_00200" /old_locus_tag="BSU00200" /label="ebfC gene" CDS 28458..29054 /gene="recR" /locus_tag="BSU_00210" /old_locus_tag="BSU00210" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12065426, 24285298, 24891441" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12065426, 24285298, 24891441; Product type f: factor" /codon_start=1 /transl_table=11 /product="recA filament-DNA complex stabilisation factor" /protein_id="NP_387902.1" /db_xref="EnsemblGenomes-Gn:BSU00210" /db_xref="EnsemblGenomes-Tr:CAB11797" /db_xref="GOA:P24277" /db_xref="InterPro:IPR000093" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR015967" /db_xref="InterPro:IPR023170" /db_xref="InterPro:IPR023627" /db_xref="InterPro:IPR023628" /db_xref="InterPro:IPR034137" /db_xref="SubtiList:BG10085" /db_xref="UniProtKB/Swiss-Prot:P24277" /translation="MQYPEPISKLIDSFMKLPGIGPKTAVRLAFFVLGMKEDVVLDFA KALVNAKRNLTYCSVCGHITDQDPCYICEDTRRDKSVICVVQDPKDVIAMEKMKEYNG QYHVLHGAISPMDGIGPEDIKIPELLKRLQDDQVTEVILATNPNIEGEATAMYISRLL KPSGIKLSRIAHGLPVGGDLEYADEVTLSKALEGRREL*" /label="recR CDS" gene 28458..29054 /gene="recR" /locus_tag="BSU_00210" /old_locus_tag="BSU00210" /label="recR gene" CDS 29072..29296 /gene="yaaL" /locus_tag="BSU_00220" /old_locus_tag="BSU00220" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_387903.1" /db_xref="EnsemblGenomes-Gn:BSU00220" /db_xref="EnsemblGenomes-Tr:CAB11798" /db_xref="InterPro:IPR019644" /db_xref="SubtiList:BG10086" /db_xref="UniProtKB/Swiss-Prot:P37533" /translation="MGFLRKKTLRREFDEKLTEQLFKQKEEWNRQKKLVEKSLEPSAE VLYELKVAEAKYFFYLREAKQRNLKISRWK*" /label="yaaL CDS" gene 29072..29296 /gene="yaaL" /locus_tag="BSU_00220" /old_locus_tag="BSU00220" /label="yaaL gene" promotor_-35 29299..29304 /Source="Nicolas_upshift_promotors" /id="U26" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1161 /SigmaFactorBS="aagcgaagcagcgaaatttaaaaatcagccggtggaagtaag tGGTCTAaactcctggatcttcTCATAAGCTTGTACTAGAAcaagcgaaggagatgag a" /listShort="bofA, S19" /listLong="rrnA-16S" /label="promotor_-35" upshifts 29316 /Source="Nicolas_upshifts" /id="U26" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1161 /SigmaFactorBS="aagcgaagcagcgaaatttaaaaatcagccggtggaagtaag tGGTCTAaactcctggatcttcTCATAAGCTTGTACTAGAAcaagcgaaggagatgag a" /listShort="bofA, S19" /listLong="rrnA-16S" /label="upshifts" promotor_-10 29320..29338 /Source="Nicolas_upshift_promotors" /id="U26" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1161 /SigmaFactorBS="aagcgaagcagcgaaatttaaaaatcagccggtggaagtaag tGGTCTAaactcctggatcttcTCATAAGCTTGTACTAGAAcaagcgaaggagatgag a" /listShort="bofA, S19" /listLong="rrnA-16S" /label="promotor_-10" CDS 29363..29626 /gene="bofA" /locus_tag="BSU_00230" /old_locus_tag="BSU00230" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15087499, 17557826" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15087499, 17557826; Product type r: regulator" /codon_start=1 /transl_table=11 /product="inhibitor of the pro-sigma(K) processing machinery" /protein_id="NP_387904.2" /db_xref="EnsemblGenomes-Gn:BSU00230" /db_xref="EnsemblGenomes-Tr:CAB11799" /db_xref="GOA:P24282" /db_xref="InterPro:IPR010001" /db_xref="SubtiList:BG10087" /db_xref="UniProtKB/Swiss-Prot:P24282" /translation="MEPIFIIGIILGLVILLFLSGSAAKPLKWIGITAVKFVAGALLL VCVNMFGGSLGIHVPINLVTTAISGILGIPGIAALVVIKQFII*" /label="bofA CDS" gene 29363..29626 /gene="bofA" /locus_tag="BSU_00230" /old_locus_tag="BSU00230" /label="bofA gene" promotor_-35 29639..29646 /Source="Nicolas_upshift_promotors" /id="U27" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2620 /SigmaFactorBS="ttaagcaatttatcatttaattgatattatgtATTGACTTag acaactgaaggTGTTATTCTAATATACGTCGctgatgacgaacagcttttttgaaaag a" /listShort="S19, rrnA-16S" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 29660..29679 /Source="Nicolas_upshift_promotors" /id="U27" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2620 /SigmaFactorBS="ttaagcaatttatcatttaattgatattatgtATTGACTTag acaactgaaggTGTTATTCTAATATACGTCGctgatgacgaacagcttttttgaaaag a" /listShort="S19, rrnA-16S" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 29667..29869 /Source="Nicolas_S_feature" /locus_tag="new_30076_30278" /HighExp="LBGstat, Diami, C30, H2O2, Oxctl, HPh, BMM, GM 120, Paraq, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 1" /TUlongSig="SigA, SigA, SigA, SigA" /TUlongPSig="0.999, 1, 0.899, 0.99" /label="S19" upshifts 29667 /Source="Nicolas_upshifts" /id="U27" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2620 /SigmaFactorBS="ttaagcaatttatcatttaattgatattatgtATTGACTTag acaactgaaggTGTTATTCTAATATACGTCGctgatgacgaacagcttttttgaaaag a" /listShort="S19, rrnA-16S" /GFF_Attribute="listLong" /label="upshifts" rRNA 29870..31423 /gene="rrnA-16S" /locus_tag="BSU_rRNA_4" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnA-16S" gene 29870..31423 /gene="rrnA-16S" /locus_tag="BSU_rRNA_4" /label="rrnA-16S gene" tRNA 31523..31599 /gene="trnA-Ile" /locus_tag="BSU_tRNA_8" /product="tRNA-Ile" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ile(GAU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnA-Ile" gene 31523..31599 /gene="trnA-Ile" /locus_tag="BSU_tRNA_8" /label="trnA-Ile gene" tRNA 31611..31686 /gene="trnA-Ala" /locus_tag="BSU_tRNA_9" /product="tRNA-Ala" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ala(UGC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnA-Ala" gene 31611..31686 /gene="trnA-Ala" /locus_tag="BSU_tRNA_9" /label="trnA-Ala gene" rRNA 31768..34694 /gene="rrnA-23S" /locus_tag="BSU_rRNA_5" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnA-23S" gene 31768..34694 /gene="rrnA-23S" /locus_tag="BSU_rRNA_5" /label="rrnA-23S gene" S_feature 34695..34827 /Source="Nicolas_S_feature" /locus_tag="new_35104_35236" /HighExp="LBGstat, G135, Oxctl, C30, HPh, Paraq, G180, LPh, T0.30H, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S20" rRNA 34828..34946 /gene="rrnA-5S" /locus_tag="BSU_rRNA_26" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnA-5S" gene 34828..34946 /gene="rrnA-5S" /locus_tag="BSU_rRNA_26" /label="rrnA-5S gene" S_feature 34947..35049 /Source="Nicolas_S_feature" /locus_tag="new_35356_35458" /HighExp="Oxctl, Paraq, H2O2, LBGstat, C30, G180, Cold, G135, Heat, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S21" promotor_-35 35010..35018 /Source="Nicolas_upshift_promotors" /id="U28" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.715284715284715" /psig="0.715284715284715" /xcortree=1057 /SigmaFactorBS="cgagaaaatcaaacaaataCAAACACCGagggcttatatagC CCATATACTGATTTAAAGTttcaaaaaggtctaaatagtgtatacaatatccgtttta a" /listShort="csfB, xpaC, yaaN, S22, yaaO, tmk" /listLong="yaaQ, yaaR, holB, yaaT" /label="promotor_-35" promotor_-10 35032..35051 /Source="Nicolas_upshift_promotors" /id="U28" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.715284715284715" /psig="0.715284715284715" /xcortree=1057 /SigmaFactorBS="cgagaaaatcaaacaaataCAAACACCGagggcttatatagC CCATATACTGATTTAAAGTttcaaaaaggtctaaatagtgtatacaatatccgtttta a" /listShort="csfB, xpaC, yaaN, S22, yaaO, tmk" /listLong="yaaQ, yaaR, holB, yaaT" /label="promotor_-10" upshifts 35051 /Source="Nicolas_upshifts" /id="U28" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.715284715284715" /psig="0.715284715284715" /xcortree=1057 /SigmaFactorBS="cgagaaaatcaaacaaataCAAACACCGagggcttatatagC CCATATACTGATTTAAAGTttcaaaaaggtctaaatagtgtatacaatatccgtttta a" /listShort="csfB, xpaC, yaaN, S22, yaaO, tmk" /listLong="yaaQ, yaaR, holB, yaaT" /label="upshifts" CDS 35122..35316 /gene="csfB" /locus_tag="BSU_00240" /old_locus_tag="BSU00240" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:8759874, 15044948, 21935351, 26929302" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8759874, 15044948, 21935351, 26929302; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="forespore-specific anti-sigma factor" /protein_id="NP_387905.1" /db_xref="EnsemblGenomes-Gn:BSU00240" /db_xref="EnsemblGenomes-Tr:CAB11800" /db_xref="GOA:P37534" /db_xref="InterPro:IPR019700" /db_xref="SubtiList:BG10088" /db_xref="UniProtKB/Swiss-Prot:P37534" /translation="MDETVKLNHTCVICDQEKNRGIHLYTKFICLDCERKVISTSTSD PDYAFYVKKLKSIHTPPLYS*" /label="csfB CDS" gene 35122..35316 /gene="csfB" /locus_tag="BSU_00240" /old_locus_tag="BSU00240" /label="csfB gene" downshifts 35300 /Source="Nicolas_upshifts" /id="D12" /incds=0 /nref=79 /ntot=215 /MaxReadThrough="5.37774" /MaxDrop="4.42494" /score="22.3916007" /energy="-6.7" /TU="U28" /idTUdmin="U27" /TUdmin=3938 /isTUend="FALSE" /label="downshifts" promotor_-35 35361..35370 /Source="Nicolas_upshift_promotors" /id="U29" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1675 /SigmaFactorBS="tctttttttgtactcttaataataaaaagaagaTGAAACTTG TttaaggattgaACGTAGTAGATAATAAtattaaaactgagtatagacacaggagtcg a" /listShort="xpaC, yaaN, S22, yaaO, tmk, yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 35382..35397 /Source="Nicolas_upshift_promotors" /id="U29" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1675 /SigmaFactorBS="tctttttttgtactcttaataataaaaagaagaTGAAACTTG TttaaggattgaACGTAGTAGATAATAAtattaaaactgagtatagacacaggagtcg a" /listShort="xpaC, yaaN, S22, yaaO, tmk, yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 35388 /Source="Nicolas_upshifts" /id="U29" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1675 /SigmaFactorBS="tctttttttgtactcttaataataaaaagaagaTGAAACTTG TttaaggattgaACGTAGTAGATAATAAtattaaaactgagtatagacacaggagtcg a" /listShort="xpaC, yaaN, S22, yaaO, tmk, yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /GFF_Attribute="listLong" /label="upshifts" CDS 35436..36050 /gene="xpaC" /locus_tag="BSU_00250" /old_locus_tag="BSU00250" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23155385; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphatase" /protein_id="NP_387906.1" /db_xref="EnsemblGenomes-Gn:BSU00250" /db_xref="EnsemblGenomes-Tr:CAB11801" /db_xref="GOA:P37467" /db_xref="InterPro:IPR018770" /db_xref="SubtiList:BG10089" /db_xref="UniProtKB/Swiss-Prot:P37467" /translation="MQRFFHFLVWSLTSSATFVFIGILSFFGLNQSIFLSIVYGLASG AAVYIAGIWNARRLFLKKHELTGREYAYIKKNLEEARQKMVRLRKALFQAKSIQMFKQ NAEMLRIVRRIYLLTKKEPKRFYQAERFFYQTLDSVVELTEKYAFLSSHPKKSKELSM SLSETRITLTELTKRLEEDLTQAMGDEIDELQFELDAAKHSLKK*" /label="xpaC CDS" gene 35436..36050 /gene="xpaC" /locus_tag="BSU_00250" /old_locus_tag="BSU00250" /label="xpaC gene" CDS 36069..37229 /gene="yaaN" /locus_tag="BSU_00260" /old_locus_tag="BSU00260" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12533473, 20713661" /codon_start=1 /transl_table=11 /product="putative toxic compound resistance protein" /protein_id="NP_387907.1" /db_xref="EnsemblGenomes-Gn:BSU00260" /db_xref="EnsemblGenomes-Tr:CAB11802" /db_xref="InterPro:IPR008863" /db_xref="SubtiList:BG10090" /db_xref="UniProtKB/Swiss-Prot:P37535" /translation="MNRDQSDLHIDELLADPFGGNIEIPGSEAVKAEKEQVRLVDVLP EENKEKAIQLAGQIDHKNMQSIVLYGSQAQSKLLNFSHDMINHVQKKDVGEIGEILGE LMKKLEQVNPDDLQSKKKGFLARMFGRVSSSLQEVLSKYQKTSVQIDRISLKLEHSKN ALISDNKLLEQLYEKNKEYFAALNVYIAAGELKLEELKTKTIPELKQQAESSDHNQMA VQEVNDLIQFADRLDKRVHDLLLSRQITIQSAPQIRLIQNTNQALAEKIQSSIVTAIP LWKNQVAIALTLLRQRNAVDAQQKVSDTTNELLLKNAELLKTNTIETARANERGLVDI DTLKKVQESLISTLEETLTIQEEGRIKRRQAEEELMMMEGDLKQKLITIKER*" /label="yaaN CDS" gene 36069..37229 /gene="yaaN" /locus_tag="BSU_00260" /old_locus_tag="BSU00260" /label="yaaN gene" S_feature 37230..37310 /Source="Nicolas_S_feature" /locus_tag="new_37639_37719" /HighExp="T0.0H, T-0.40H, T0.30H, T-1.10H, T-1.40H, Salt, T1.0H, G150, Diami, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY, SigK" /TUshortPSig="0.984, 0.715" /TUlongSig="NA" /TUlongPSig="NA" /label="S22" CDS 37311..38753 /gene="yaaO" /locus_tag="BSU_00270" /old_locus_tag="BSU00270" /EC_number="4.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9723923, 20876533, 24529384; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative decarboxylase" /protein_id="NP_387908.1" /db_xref="EnsemblGenomes-Gn:BSU00270" /db_xref="EnsemblGenomes-Tr:CAB11803" /db_xref="GOA:P37536" /db_xref="InterPro:IPR000310" /db_xref="InterPro:IPR008286" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036633" /db_xref="SubtiList:BG10091" /db_xref="UniProtKB/Swiss-Prot:P37536" /translation="MNTPLYKALIQHARRNSHSFHVPGHHNGDVFFDDAKSIFDPLLT IDVTELAGLDDLHHPSGVIKEAQELASQLYGSAESFFLVNGTTVGNLAMILSVCEPGD TILVQRNCHKSVFHAVDLSGAEPVYLAPDVDSAMHVPTHVPLGTIKEALEAYPDAKGL VLTNPTYYGHSADLTEIITEAHHYGIPVLVDEAHGAHFILGEPFPVSALKMGADIVVQ SAHKTLPAMTMGSYLHLNSSCRINRDRVAEYLNRLQSSSPSYPIMASLDIARAYVQHI IEEQKLSDILQRIETLKQTFDSLTNAEAVNPANPLIITDPLKLTIRSKRGHSGYTLQS ILERANIFTELADENQVLLVLPLGGKRRINAEIIRSIDEEIEKTPPDQTFVSAEWGVQ PVTVLPYPKKVLHSFKKEYVSFEEAAGRLNAEDIIPYPPGIPMIMAGERITKESVQKL SRLISMKTHVQGNMKIKEKQLLVYIEEEKS*" /label="yaaO CDS" gene 37311..38753 /gene="yaaO" /locus_tag="BSU_00270" /old_locus_tag="BSU00270" /label="yaaO gene" promotor_-35 38673..38679 /Source="Nicolas_upshift_promotors" /id="U30" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.513486513486514" /psig="0.513486513486514" /xcortree=105 /SigmaFactorBS="gaaagtgtgcaaaagctcagccgcttgatcAGCATGAaaacg catgttcaaGGGAATATGAAAATCAAAGagaaacaactacttgtttatatagaagagg a" /listShort="tmk" /listLong="yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /label="promotor_-35" promotor_-10 38694..38712 /Source="Nicolas_upshift_promotors" /id="U30" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.513486513486514" /psig="0.513486513486514" /xcortree=105 /SigmaFactorBS="gaaagtgtgcaaaagctcagccgcttgatcAGCATGAaaacg catgttcaaGGGAATATGAAAATCAAAGagaaacaactacttgtttatatagaagagg a" /listShort="tmk" /listLong="yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /label="promotor_-10" upshifts 38703 /Source="Nicolas_upshifts" /id="U30" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.513486513486514" /psig="0.513486513486514" /xcortree=105 /SigmaFactorBS="gaaagtgtgcaaaagctcagccgcttgatcAGCATGAaaacg catgttcaaGGGAATATGAAAATCAAAGagaaacaactacttgtttatatagaagagg a" /listShort="tmk" /listLong="yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /label="upshifts" CDS 38750..39388 /gene="tmk" /locus_tag="BSU_00280" /old_locus_tag="BSU00280" /EC_number="2.7.4.9" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9696781, 12682299, 18523102" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9696781, 12682299, 18523102; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thymidylate kinase" /protein_id="NP_387909.2" /db_xref="EnsemblGenomes-Gn:BSU00280" /db_xref="EnsemblGenomes-Tr:CAB11804" /db_xref="GOA:P37537" /db_xref="InterPro:IPR018094" /db_xref="InterPro:IPR018095" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10092" /db_xref="UniProtKB/Swiss-Prot:P37537" /translation="MSGLFITFEGPEGAGKTTVLQEIKNILTAEGLQVMATREPGGID IAEQIREVILNENNILMDPKTEALLYAAARRQHLVEKVKPALEQGFIVLCDRFIDSSL AYQGYARGLGIDEVLSINEFAIGDMMPHVTVYFSIDPEEGLKRIYANGSREKNRLDLE KLDFHTKVQEGYQELMKRFPERFHSVDAGQSKDLVVQDVLKVIDEALKKIQL*" /label="tmk CDS" gene 38750..39388 /gene="tmk" /locus_tag="BSU_00280" /old_locus_tag="BSU00280" /label="tmk gene" promotor_-35 39383..39390 /Source="Nicolas_upshift_promotors" /id="U31" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.478521478521479" /psig="0.964035964035964" /xcortree=91 /SigmaFactorBS="tgatcgatgaagcgttgaaaaaaattcaaTTGTGACCtgttt cccaataGTTGATATAATAATGTAAACgagatcacgttgtttccaatctaaaggaggc c" /listShort="yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 39403..39422 /Source="Nicolas_upshift_promotors" /id="U31" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.478521478521479" /psig="0.964035964035964" /xcortree=91 /SigmaFactorBS="tgatcgatgaagcgttgaaaaaaattcaaTTGTGACCtgttt cccaataGTTGATATAATAATGTAAACgagatcacgttgtttccaatctaaaggaggc c" /listShort="yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 39414 /Source="Nicolas_upshifts" /id="U31" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.478521478521479" /psig="0.964035964035964" /xcortree=91 /SigmaFactorBS="tgatcgatgaagcgttgaaaaaaattcaaTTGTGACCtgttt cccaataGTTGATATAATAATGTAAACgagatcacgttgtttccaatctaaaggaggc c" /listShort="yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /GFF_Attribute="listLong" /label="upshifts" CDS 39462..39791 /gene="darA" /locus_tag="BSU_00290" /old_locus_tag="BSU00290" /experiment="publication(s) with functional evidences, PMID:10913081, 25433025" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10913081, 25433025; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="signal transduction receptor, cyclic di-AMP binding" /protein_id="NP_387910.1" /db_xref="EnsemblGenomes-Gn:BSU00290" /db_xref="EnsemblGenomes-Tr:CAB11805" /db_xref="InterPro:IPR010375" /db_xref="InterPro:IPR011322" /db_xref="InterPro:IPR015867" /db_xref="PDB:4RLE" /db_xref="SubtiList:BG10093" /db_xref="UniProtKB/Swiss-Prot:P37538" /translation="MKLIVAVVQDQDSNRLLKTLTDHNFRVTKLATTGGFLKSGNTTF MIGVEDIRVNKALSLIKENGQKRDQMIAPVSPMGGNADSYVPYPVEVEVGGATVFVLP VDEFHQF*" /label="darA CDS" gene 39462..39791 /gene="darA" /locus_tag="BSU_00290" /old_locus_tag="BSU00290" /label="darA gene" CDS 39804..40244 /gene="yaaR" /locus_tag="BSU_00300" /old_locus_tag="BSU00300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22333191, 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_387911.1" /db_xref="EnsemblGenomes-Gn:BSU00300" /db_xref="EnsemblGenomes-Tr:CAB11806" /db_xref="InterPro:IPR005585" /db_xref="InterPro:IPR024042" /db_xref="SubtiList:BG10094" /db_xref="UniProtKB/Swiss-Prot:P37539" /translation="MKINKDIRTFIDNKQIPSVKTSEITASFKTSMENQSSKMKLDQL TRLLSDIEAFGKRLTKSRNFKDLARFKGLVKRFVKEAVDSGLSHETSKSFDLYGNSRT LGLVKEIDDKLIQLTEEMMDQEKPAIDLLERIGEIKGLLINLYT*" /label="yaaR CDS" gene 39804..40244 /gene="yaaR" /locus_tag="BSU_00300" /old_locus_tag="BSU00300" /label="yaaR gene" CDS 40256..41245 /gene="holB" /locus_tag="BSU_00310" /old_locus_tag="BSU00310" /EC_number="2.7.7.7" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:8509334, 12060778, 12682299, 22333191, 23525462" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8509334, 12060778, 12682299, 22333191, 23525462; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase III clamp loader delta' subunit" /protein_id="NP_387912.1" /db_xref="EnsemblGenomes-Gn:BSU00310" /db_xref="EnsemblGenomes-Tr:CAB11807" /db_xref="GOA:P37540" /db_xref="InterPro:IPR004622" /db_xref="InterPro:IPR015199" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10095" /db_xref="UniProtKB/Swiss-Prot:P37540" /translation="MAISWKEMNELQPRVMKLLYNSIEKDRLSHAYLFEGKKGTGKLD AALLLAKSFFCLEGGAEPCESCRNCKRIESGNHPDLHLVQPDGLSIKKAQIQALQEEF SKTGLESHKKLYIISHADQMTANAANSLLKFLEEPNKDTMAVLITEQPQRLLDTIISR CQTLPFQPLQPKAIEDRLIEQDVSPHMARLLANMTNNVAEAVELSRNDEFAESRAKVI KLYEVLHQRKGHAFFFIQDQWMPFFKEKTHQEMGLDMLLLIYRDVLSIQIGNEDKLIY QDLFQSIKQHALQSTQQSVTNQILAVLEAKKRLHSNVNVQGLMEHLVLMLQEG*" /label="holB CDS" gene 40256..41245 /gene="holB" /locus_tag="BSU_00310" /old_locus_tag="BSU00310" /label="holB gene" CDS 41248..42075 /gene="ricT" /locus_tag="BSU_00320" /old_locus_tag="BSU00320" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12270811, 23490197, 26434553, 27501195, 28295778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12270811, 23490197, 26434553, 27501195, 28295778; Product type r: regulator" /codon_start=1 /transl_table=11 /product="subunit of a sporulation, competence and biofilmformation regulatory complex of RNaseY (RicAFT complex /FAD / two [4Fe-4S]2+)" /protein_id="NP_387913.1" /db_xref="EnsemblGenomes-Gn:BSU00320" /db_xref="EnsemblGenomes-Tr:CAB11808" /db_xref="GOA:P37541" /db_xref="InterPro:IPR007557" /db_xref="SubtiList:BG10096" /db_xref="UniProtKB/Swiss-Prot:P37541" /translation="MYNVIGVRFKKAGKIYYFDPNGFHIEHDSCVIVETVRGVEYGQV VIANKQVDEHDVVLPLRKVIRVADDRDLLIVEENKQEALSAFDICQKKVIEHGLDMKL VDVEFTFDRNKVIFYFTADGRVDFRELVKDLASIFKTRIELRQIGVRDEAKMLGGIGP CGRMLCCSTFLGDFEPVSIKMAKDQNLSLNPTKISGLCGRLMCCLKYENDEYETAKEQ LPDIGEMITTANGPAKVVGLNILERVLQVELINREKVIEYTWEELLEEGVVSAQTTD* " /label="ricT CDS" gene 41248..42075 /gene="ricT" /locus_tag="BSU_00320" /old_locus_tag="BSU00320" /label="ricT gene" CDS 42090..42449 /gene="dnaH" /locus_tag="BSU_00330" /old_locus_tag="BSU00330" /function="16.9: Replicate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15927750, 16461910, 19737352, 21895792, 23909787, 28166228" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15927750, 16461910, 19737352, 21895792, 23909787, 28166228; Product type f : factor" /codon_start=1 /transl_table=11 /product="subunit of the DNA replication complex" /protein_id="NP_387914.1" /db_xref="EnsemblGenomes-Gn:BSU00330" /db_xref="EnsemblGenomes-Tr:CAB11809" /db_xref="GOA:P37542" /db_xref="InterPro:IPR010377" /db_xref="PDB:5DOL" /db_xref="SubtiList:BG10097" /db_xref="UniProtKB/Swiss-Prot:P37542" /translation="MDKKELFDTVINLEEQIGSLYRQLGDLKQHIGEMIEENHHLQLE NKHLRKRLDDTTQQIEKFKADKKESKTQKTEQTDIGEGYDNLARLYQEGFHICNVHYG SVRKEDCLFCLSFLNKK*" /label="dnaH CDS" gene 42090..42449 /gene="dnaH" /locus_tag="BSU_00330" /old_locus_tag="BSU00330" /label="dnaH gene" CDS 42508..43251 /gene="trmNF" /locus_tag="BSU_00340" /old_locus_tag="BSU00340" /EC_number="2.1.1.223" /function="10.3: tRNA and rRNA base modification" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 22905870, 24809820; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA1(Val) (adenine(37)-N6)-methyltransferase" /protein_id="NP_387915.1" /db_xref="EnsemblGenomes-Gn:BSU00340" /db_xref="EnsemblGenomes-Tr:CAB11810" /db_xref="GOA:P37543" /db_xref="InterPro:IPR007848" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG10098" /db_xref="UniProtKB/Swiss-Prot:P37543" /translation="MVSLHDDERLDYLLAEDMKIIQSPTVFAFSLDAVLLSKFAYVPI QKGKIVDLCTGNGIVPLLLSTRSKADILGVEIQERLHDMAVRSVEYNKLDDQIQIIHD DLKNMPEKLGHNRYDVVTCNPPYFKTPKQTEQNMNEHLRIARHEIHCTLEDVISVSSK LLKQGGKAALVHRPGRLLEIFELMKAYQIEPKRVQFVYPKQGKEANTILVEGIKGGRP DLKILPPLFVYDEQNEYTKEIRTILYGDK*" /label="trmNF CDS" gene 42508..43251 /gene="trmNF" /locus_tag="BSU_00340" /old_locus_tag="BSU00340" /label="trmNF gene" CDS 43238..43537 /gene="yazA" /locus_tag="BSU_00350" /old_locus_tag="BSU00350" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11483577; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative UvrC-Intron-type (URI) endonuclease" /protein_id="NP_387916.1" /db_xref="EnsemblGenomes-Gn:BSU00350" /db_xref="EnsemblGenomes-Tr:CAB11811" /db_xref="InterPro:IPR000305" /db_xref="InterPro:IPR035901" /db_xref="SubtiList:BG12700" /db_xref="UniProtKB/Swiss-Prot:O31414" /translation="METNNHFFYVVKCKDNSWYAGYTNDLHKRVKTHNDGKGAKYTKV RRPVELIFAESFSTKREAMQAEYYFKKLTRKKKELYIEEKRNSKEAVYVKAPNEL*" /label="yazA CDS" gene 43238..43537 /gene="yazA" /locus_tag="BSU_00350" /old_locus_tag="BSU00350" /label="yazA gene" CDS 43512..44390 /gene="rsmI" /locus_tag="BSU_00360" /old_locus_tag="BSU00360" /EC_number="2.1.1.198" /function="16.8: Protect" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16014871, 19965768, 25893373; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="16S rRNA 2'-O-ribose C1402 methyltransferase" /protein_id="NP_387917.1" /db_xref="EnsemblGenomes-Gn:BSU00360" /db_xref="EnsemblGenomes-Tr:CAB11812" /db_xref="GOA:P37544" /db_xref="InterPro:IPR000878" /db_xref="InterPro:IPR008189" /db_xref="InterPro:IPR014776" /db_xref="InterPro:IPR014777" /db_xref="InterPro:IPR018063" /db_xref="InterPro:IPR035996" /db_xref="SubtiList:BG10099" /db_xref="UniProtKB/Swiss-Prot:P37544" /translation="MLRRQMSFNGKSDMGILYLVPTPIGNLEDMTFRAIDTLKSVDAI AAEDTRQTKKLCHVYEIETPLVSYHEHNKESSGHKIIEWLKSGKNIALVSDAGLPTIS DPGAEIVKDFTDIGGYVVPLPGANAALTALIASGIVPQPFFFYGFLNRQKKEKKKELE ALKKRQETIIFYEAPHRLKETLSAMAEILGDREIAVTRELTKKYEEFIRGTISEVIGW ANEDQIRGEFCLVVEGSNNEEVDEEEQWWETLTAKEHVEHYISKGATSKEAIKKAAVD RNVPKREVYDAYHIKQ*" /label="rsmI CDS" gene 43512..44390 /gene="rsmI" /locus_tag="BSU_00360" /old_locus_tag="BSU00360" /label="rsmI gene" downshifts 44363 /Source="Nicolas_upshifts" /id="D13" /incds=0 /nref=23 /ntot=177 /MaxReadThrough="3.33195" /MaxDrop="3.72723" /score="5.97354542" /energy="-10.2" /TU="U29,U31" /idTUdmin="U29" /TUdmin="-23" /isTUend="FALSE" /label="downshifts" CDS complement(44439..44729) /gene="abrB" /locus_tag="BSU_00370" /old_locus_tag="BSU00370" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10754235, 10809710, 11101881, 11101897, 16159768, 16223496, 16702211, 25308864, 25381239, 18676675, 22183144, 23196984, 24832089, 24847778, 25288929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10754235, 10809710, 11101881, 11101897, 16159768, 16223496, 16702211, 25308864, 25381239, 18676675, 22183144, 23196984, 24832089, 24847778, 25288929; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator for transition state genes (AbrB-SurF)" /protein_id="NP_387918.1" /db_xref="EnsemblGenomes-Gn:BSU00370" /db_xref="EnsemblGenomes-Tr:CAB11813" /db_xref="GOA:P08874" /db_xref="InterPro:IPR007159" /db_xref="PDB:1YFB" /db_xref="PDB:1YSF" /db_xref="PDB:1Z0R" /db_xref="PDB:2K1N" /db_xref="PDB:2MJG" /db_xref="PDB:2RO4" /db_xref="SubtiList:BG10100" /db_xref="UniProtKB/Swiss-Prot:P08874" /translation="MFMKSTGIVRKVDELGRVVIPIELRRTLGIAEKDALEIYVDDEK IILKKYKPNMTCQVTGEVSDDNLKLAGGKLVLSKEGAEQIISEIQNQLQNLK*" /label="abrB CDS" gene complement(44439..44729) /gene="abrB" /locus_tag="BSU_00370" /old_locus_tag="BSU00370" /label="abrB gene" downshifts complement(44441) /Source="Nicolas_upshifts" /id="D14" /incds=0 /nref=216 /ntot=263 /MaxReadThrough="2.17237" /MaxDrop="7.75729" /score="20.9582436" /energy="-10.2" /TU="U32" /idTUdmin="U32" /TUdmin="-23" /isTUend="FALSE" /label="downshifts" downshifts 44760 /Source="Nicolas_upshifts" /id="D15" /incds=0 /nref=1 /ntot=15 /MaxReadThrough="2.53543" /MaxDrop="4.31699" /score="13.7153159" /energy="-14.4" /TU="NA" /idTUdmin="U29" /TUdmin=374 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(44796..44815) /Source="Nicolas_upshift_promotors" /id="U32" /multdbtbs="SigA,SigA" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=2122 /SigmaFactorBS="tataagaactaattcttacaatcaatagtaaacaaaaTGATT GACgattattggaaacCTTGTTATGCTATGAAGGTAaggattttgtcgaataatgacg a" /listShort="abrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(44813) /Source="Nicolas_upshifts" /id="U32" /multdbtbs="SigA,SigA" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=2122 /SigmaFactorBS="tataagaactaattcttacaatcaatagtaaacaaaaTGATT GACgattattggaaacCTTGTTATGCTATGAAGGTAaggattttgtcgaataatgacg a" /listShort="abrB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(44815..44990) /Source="Nicolas_S_feature" /locus_tag="new_45224_45399_c" /HighExp="C30, H2O2, G180, Etha, S0, GM 25, Gly, G135, MG 25, MG-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S23" promotor_-35 complement(44829..44836) /Source="Nicolas_upshift_promotors" /id="U32" /multdbtbs="SigA,SigA" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=2122 /SigmaFactorBS="tataagaactaattcttacaatcaatagtaaacaaaaTGATT GACgattattggaaacCTTGTTATGCTATGAAGGTAaggattttgtcgaataatgacg a" /listShort="abrB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(44986..45005) /Source="Nicolas_upshift_promotors" /id="U33" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.603396603396603" /psig="0.993006993006993" /xcortree=2123 /SigmaFactorBS="aaatctttaatgaaaataaaaaaaGTCTGTTCgtgtcgaatt ttgTCGTATATAATCAAATGAAAtaaaaaactttggttcgaaagtcttgatttaaaag g" /listShort="S23" /listLong="abrB" /label="promotor_-10" upshifts complement(44990) /Source="Nicolas_upshifts" /id="U33" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.603396603396603" /psig="0.993006993006993" /xcortree=2123 /SigmaFactorBS="aaatctttaatgaaaataaaaaaaGTCTGTTCgtgtcgaatt ttgTCGTATATAATCAAATGAAAtaaaaaactttggttcgaaagtcttgatttaaaag g" /listShort="S23" /listLong="abrB" /label="upshifts" promotor_-35 complement(45019..45026) /Source="Nicolas_upshift_promotors" /id="U33" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.603396603396603" /psig="0.993006993006993" /xcortree=2123 /SigmaFactorBS="aaatctttaatgaaaataaaaaaaGTCTGTTCgtgtcgaatt ttgTCGTATATAATCAAATGAAAtaaaaaactttggttcgaaagtcttgatttaaaag g" /listShort="S23" /listLong="abrB" /label="promotor_-35" promotor_-35 45090..45094 /Source="Nicolas_upshift_promotors" /id="U34" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.803196803196803" /psig="0.999000999001" /xcortree=2569 /SigmaFactorBS="ttttaattattctttttcagggcgtatgtatatatTCTTGat cttaaaggctaaGATGGTATCATAGATAAAGGataaatataaataatattcatatatg a" /listShort="S24, metS, yabD, S26, yabE" /listLong="S27, rnmV, ksgA" /label="promotor_-35" promotor_-10 45109..45128 /Source="Nicolas_upshift_promotors" /id="U34" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.803196803196803" /psig="0.999000999001" /xcortree=2569 /SigmaFactorBS="ttttaattattctttttcagggcgtatgtatatatTCTTGat cttaaaggctaaGATGGTATCATAGATAAAGGataaatataaataatattcatatatg a" /listShort="S24, metS, yabD, S26, yabE" /listLong="S27, rnmV, ksgA" /label="promotor_-10" S_feature 45115..45223 /Source="Nicolas_S_feature" /locus_tag="new_45524_45632" /HighExp="LBGtran, Heat, dia5, dia15, LBGexp, Lbexp, dia0, H2O2, Diami, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S24" upshifts 45115 /Source="Nicolas_upshifts" /id="U34" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.803196803196803" /psig="0.999000999001" /xcortree=2569 /SigmaFactorBS="ttttaattattctttttcagggcgtatgtatatatTCTTGat cttaaaggctaaGATGGTATCATAGATAAAGGataaatataaataatattcatatatg a" /listShort="S24, metS, yabD, S26, yabE" /listLong="S27, rnmV, ksgA" /label="upshifts" CDS 45224..47218 /gene="metS" /locus_tag="BSU_00380" /old_locus_tag="BSU00380" /EC_number="6.1.1.10" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11233169, 12682299, 12792655; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methionyl-tRNA synthetase" /protein_id="NP_387919.1" /db_xref="EnsemblGenomes-Gn:BSU00380" /db_xref="EnsemblGenomes-Tr:CAB11814" /db_xref="GOA:P37465" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR002547" /db_xref="InterPro:IPR004495" /db_xref="InterPro:IPR009080" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR013155" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR014758" /db_xref="InterPro:IPR015413" /db_xref="InterPro:IPR023457" /db_xref="InterPro:IPR033911" /db_xref="SubtiList:BG10101" /db_xref="UniProtKB/Swiss-Prot:P37465" /translation="MPQENNTFYITTPIYYPSGKLHIGHAYTTVAGDAMARYKRLKGF DVRYLTGTDEHGQKIQQKAEQENITPQEYVDRAAADIQKLWKQLEISNDDFIRTTEKR HKVVIEKVFQKLLDNGDIYLDEYEGWYSIPDETFYTETQLVDIERNEKGEVIGGKSPD SGHPVELIKEESYFFRMGKYADRLLKYYEENPTFIQPESRKNEMINNFIKPGLEDLAV SRTTFDWGVKVPENPKHVVYVWIDALFNYLTALGYDTENDELYQKYWPADVHLVGKEI VRFHTIYWPIMLMALDLPLPKQVFAHGWLLMKDGKMSKSKGNVVDPVTLIERYGLDEL RYYLLREVPFGSDGVFTPEGFVERINYDLANDLGNLLNRTVAMINKYFDGQIGSYKGA VTEFDHTLTSVAEETVKAYEKAMENMEFSVALSTLWQLISRTNKYIDETAPWVLAKDP AKEEELRSVMYHLAESLRISAVLLQPFLTKTPEKMFEQLGITDESLKAWDSITAFGQL KDTKVQKGEPLFPRLEAEEEIAYIKGKMQGSAPAKEETKEEEPQEVDRLPEITIDQFM DVELRVAEVIEAEPVKKADRLLKLQLDLGFEKRQVVSGIAKHYTPEELVGKKLVCVTN LKPVKLRGELSQGMILAGEADGVLKVVSIDQSLPKGTRIK*" /label="metS CDS" gene 45224..47218 /gene="metS" /locus_tag="BSU_00380" /old_locus_tag="BSU00380" /label="metS gene" promotor_-10 complement(45972..45991) /Source="Nicolas_upshift_promotors" /id="U35" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1824 /SigmaFactorBS="cgactaaatgaacatcggcaggccaatatTTTTGataaagct catcattTTCTGTATCATAACCGAGTGccgttaaatagttaaatagtgcgtcaatcca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(45980) /Source="Nicolas_upshifts" /id="U35" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1824 /SigmaFactorBS="cgactaaatgaacatcggcaggccaatatTTTTGataaagct catcattTTCTGTATCATAACCGAGTGccgttaaatagttaaatagtgcgtcaatcca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(46007..46011) /Source="Nicolas_upshift_promotors" /id="U35" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1824 /SigmaFactorBS="cgactaaatgaacatcggcaggccaatatTTTTGataaagct catcattTTCTGTATCATAACCGAGTGccgttaaatagttaaatagtgcgtcaatcca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 47202 /Source="Nicolas_upshifts" /id="D16" /incds=0 /nref=18 /ntot=206 /MaxReadThrough="4.8491" /MaxDrop="2.9167" /score="13.7153159" /energy="-14.4" /TU="U34" /idTUdmin="U34" /TUdmin="-2288" /isTUend="FALSE" /label="downshifts" S_feature complement(47264..49610) /Source="Nicolas_S_feature" /locus_tag="new_47673_50019_c" /HighExp="T0.30H, T1.0H, T1.30H, Salt, C30, T2.0H, T-0.40H, T0.0H, T2.30H, T-1.10H" /AntisenseName="yabE" /AntisenseCor="-0.28154713646185298" /AntisenseRegPval="-5.6" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S25" CDS 47297..48064 /gene="dayD" /locus_tag="BSU_00390" /old_locus_tag="BSU00390" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10747959, 16014871, 16461678, 19332551; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-amino acyl-tRNA deacylase" /protein_id="NP_387920.1" /db_xref="EnsemblGenomes-Gn:BSU00390" /db_xref="EnsemblGenomes-Tr:CAB11815" /db_xref="GOA:P37545" /db_xref="InterPro:IPR001130" /db_xref="InterPro:IPR015991" /db_xref="InterPro:IPR018228" /db_xref="InterPro:IPR032466" /db_xref="SubtiList:BG10102" /db_xref="UniProtKB/Swiss-Prot:P37545" /translation="MLFDTHAHLNAEQYDTDLEEVIERAKAEKVERIVVVGFDRPTIT RAMEMIEEYDFIYAAIGWHPVDAIDMTEEDLAWIKELSAHEKVVAIGEMGLDYHWDKS PKDIQKEVFRNQIALAKEVNLPIIIHNRDATEDVVTILKEEGAEAVGGIMHCFTGSAE VARECMKMNFYLSFGGPVTFKNAKKPKEVVKEIPNDRLLIETDCPFLTPHPFRGKRNE PSYVKYVAEQIAELKEMTFEEIASITTENAKRLFRIN*" /label="dayD CDS" gene 47297..48064 /gene="dayD" /locus_tag="BSU_00390" /old_locus_tag="BSU00390" /label="dayD gene" S_feature 48065..48145 /Source="Nicolas_S_feature" /locus_tag="new_48474_48554" /HighExp="Heat, C30, LBGtran, LBGstat, C90, Etha, M40t45, LPhT, MG 15, Gly" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S26" promotor_-35 48122..48127 /Source="Nicolas_upshift_promotors" /id="U36" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.943056943056943" /psig="0.943056943056943" /xcortree=438 /SigmaFactorBS="taagagcttgtcccttacagcgtttttctataaaaGTTCTAc atgctttcttctccTCATAGGATAGGTTTGTCGacaagtctttcttccgtttctcagt g" /listShort="yabE, S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 48143..48161 /Source="Nicolas_upshift_promotors" /id="U36" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.943056943056943" /psig="0.943056943056943" /xcortree=438 /SigmaFactorBS="taagagcttgtcccttacagcgtttttctataaaaGTTCTAc atgctttcttctccTCATAGGATAGGTTTGTCGacaagtctttcttccgtttctcagt g" /listShort="yabE, S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 48147 /Source="Nicolas_upshifts" /id="U36" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.943056943056943" /psig="0.943056943056943" /xcortree=438 /SigmaFactorBS="taagagcttgtcccttacagcgtttttctataaaaGTTCTAc atgctttcttctccTCATAGGATAGGTTTGTCGacaagtctttcttccgtttctcagt g" /listShort="yabE, S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 48172..48175 /Source="Nicolas_upshift_promotors" /id="U37" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.705294705294705" /psig="0.843156843156843" /xcortree=440 /SigmaFactorBS="aggataggtttgtcgacaagtctttCTTCcgtttctcagtgt aTTTCAGGATAATGAAGAGGAcactgagcttttgggagaaagagaagggagggttgac a" /listShort="yabE, S27" /listLong="rnmV, ksgA" /label="promotor_-35" promotor_-10 48190..48209 /Source="Nicolas_upshift_promotors" /id="U37" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.705294705294705" /psig="0.843156843156843" /xcortree=440 /SigmaFactorBS="aggataggtttgtcgacaagtctttCTTCcgtttctcagtgt aTTTCAGGATAATGAAGAGGAcactgagcttttgggagaaagagaagggagggttgac a" /listShort="yabE, S27" /listLong="rnmV, ksgA" /label="promotor_-10" upshifts 48207 /Source="Nicolas_upshifts" /id="U37" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.705294705294705" /psig="0.843156843156843" /xcortree=440 /SigmaFactorBS="aggataggtttgtcgacaagtctttCTTCcgtttctcagtgt aTTTCAGGATAATGAAGAGGAcactgagcttttgggagaaagagaagggagggttgac a" /listShort="yabE, S27" /listLong="rnmV, ksgA" /label="upshifts" CDS 48220..49533 /gene="yabE" /locus_tag="BSU_00400" /old_locus_tag="BSU00400" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15774001, 19047346; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative cell wall shaping enzyme" /protein_id="NP_387921.1" /db_xref="EnsemblGenomes-Gn:BSU00400" /db_xref="EnsemblGenomes-Tr:CAB11816" /db_xref="GOA:P37546" /db_xref="InterPro:IPR007137" /db_xref="InterPro:IPR010611" /db_xref="InterPro:IPR011098" /db_xref="InterPro:IPR036908" /db_xref="SubtiList:BG10103" /db_xref="UniProtKB/Swiss-Prot:P37546" /translation="MGEREGRVDSLLDTLYNLSEEKEAFFITQKMKKLFSVKLSKSKV ILVAACLLLAGSGTAYAAHELTKQSVSVSINGKKKHIRTHANTVGDLLETLDIKTRDE DKITPAKQTKITADMDVVYEAAKPVKLTINGEEKTLWSTAKTVGALLDEQDVDVKEQD QIDPAIDTDISKDMKINIEPAFQVTVNDAGKQKKIWTTSTTVADFLKQQKMNIKDEDK IKPALDAKLTKGKADITITRIEKVTDVVEEKIAFDVKKQEDASLEKGKEKVVQKGKEG KLKKHFEVVKENGKEVSRELVKEETAEQSKDKVIAVGTKQSSPKFETVSASGDSKTVV SRSNESTGKVMTVSSTAYTASCSGCSGHTATGVNLKNNPNAKVIAVDPNVIPLGSKVH VEGYGYAIAADTGSAIKGNKIDVFFPEKSSAYRWGNKTVKIKILN*" /label="yabE CDS" gene 48220..49533 /gene="yabE" /locus_tag="BSU_00400" /old_locus_tag="BSU00400" /label="yabE gene" promotor_-35 48240..48247 /Source="Nicolas_upshift_promotors" /id="U38" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2420 /SigmaFactorBS="taatgaagaggacactgagcttttgggagaaagagaagggag GGTTGACAgccttttagatactCTATATAATCTCTCCGAGGAgaaggaggcgtttttc a" /listShort="yabE, S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 48258 /Source="Nicolas_upshifts" /id="U38" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2420 /SigmaFactorBS="taatgaagaggacactgagcttttgggagaaagagaagggag GGTTGACAgccttttagatactCTATATAATCTCTCCGAGGAgaaggaggcgtttttc a" /listShort="yabE, S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 48262..48281 /Source="Nicolas_upshift_promotors" /id="U38" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2420 /SigmaFactorBS="taatgaagaggacactgagcttttgggagaaagagaagggag GGTTGACAgccttttagatactCTATATAATCTCTCCGAGGAgaaggaggcgtttttc a" /listShort="yabE, S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 49494 /Source="Nicolas_upshifts" /id="D17" /incds=0 /nref=87 /ntot=220 /MaxReadThrough="5.02755" /MaxDrop="4.87493" /score="27.529638" /energy="-11.3" /TU="U36,U37,U38" /idTUdmin="U34" /TUdmin=4 /isTUend="TRUE" /label="downshifts" promotor_-35 49556..49560 /Source="Nicolas_upshift_promotors" /id="U39" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.928071928071928" /psig=1 /xcortree=2584 /SigmaFactorBS="taaaatcttaaattagtatatacttatgtattcagaggGTTT TgcgccctctgtttttTTCGTTATAATAGACAAAGTgcattttctgcttattagacgc t" /listShort="S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 49576..49595 /Source="Nicolas_upshift_promotors" /id="U39" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.928071928071928" /psig=1 /xcortree=2584 /SigmaFactorBS="taaaatcttaaattagtatatacttatgtattcagaggGTTT TgcgccctctgtttttTTCGTTATAATAGACAAAGTgcattttctgcttattagacgc t" /listShort="S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 49578..49677 /Source="Nicolas_S_feature" /locus_tag="new_49987_50086" /HighExp="LoTm, H2O2, G180, G135, G150, Paraq, Oxctl, C30, dia15, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigEF" /TUshortPSig="1, 1, 0.843, 0.943" /TUlongSig="SigA" /TUlongPSig="0.999" /label="S27" upshifts 49578 /Source="Nicolas_upshifts" /id="U39" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.928071928071928" /psig=1 /xcortree=2584 /SigmaFactorBS="taaaatcttaaattagtatatacttatgtattcagaggGTTT TgcgccctctgtttttTTCGTTATAATAGACAAAGTgcattttctgcttattagacgc t" /listShort="S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(49602..49617) /Source="Nicolas_upshift_promotors" /id="U40" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2365 /SigmaFactorBS="ttatttcctccaagacaaaataaaaacttttgtatattcaTG AAACTTTTtcttatatcgaGCGTCTAATAAGCAGAaaatgcactttgtctattataac g" /listShort="S25" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(49618) /Source="Nicolas_upshifts" /id="U40" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2365 /SigmaFactorBS="ttatttcctccaagacaaaataaaaacttttgtatattcaTG AAACTTTTtcttatatcgaGCGTCTAATAAGCAGAaaatgcactttgtctattataac g" /listShort="S25" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(49629..49638) /Source="Nicolas_upshift_promotors" /id="U40" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2365 /SigmaFactorBS="ttatttcctccaagacaaaataaaaacttttgtatattcaTG AAACTTTTtcttatatcgaGCGTCTAATAAGCAGAaaatgcactttgtctattataac g" /listShort="S25" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 49674..49690 /Source="Nicolas_upshift_promotors" /id="U41" /multdbtbs="-" /comp="M11" /sig="Sig-" /pcomp="0.48051948051948" /psig="0.48051948051948" /xcortree=100 /SigmaFactorBS="aaaaagtttcatgaatatacaaaagtttttattttgtcttgg aggaAATAATGAAAATTAAAGagatcattgtggtcgaggggcgtgacgatacggcccg c" /listShort="rnmV, ksgA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 49678..50238 /gene="rnmV" /locus_tag="BSU_00410" /old_locus_tag="BSU00410" /EC_number="3.1.26.8" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11233981, 11976317, 12794188, 16077031" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11233981, 11976317, 12794188, 16077031; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease M5" /protein_id="NP_387922.1" /db_xref="EnsemblGenomes-Gn:BSU00410" /db_xref="EnsemblGenomes-Tr:CAB11817" /db_xref="GOA:P37547" /db_xref="InterPro:IPR004466" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR025156" /db_xref="InterPro:IPR034141" /db_xref="SubtiList:BG10104" /db_xref="UniProtKB/Swiss-Prot:P37547" /translation="MKIKEIIVVEGRDDTARIKLAVDADTIETNGSAIDDHVIDQIRL AQKTRGVIILTDPDFPGEKIRKTISEAVPGCKHAFLPKHLAKPKNKRGIGVEHASVES IRACLENVHEEMEAQPSDISAEDLIHAGLIGGPAAKCRRERLGDLLKIGYTNGKQLQK RLQMFQIKKSDFMSALDTVMREEQNE*" /label="rnmV CDS" gene 49678..50238 /gene="rnmV" /locus_tag="BSU_00410" /old_locus_tag="BSU00410" /label="rnmV gene" upshifts 49688 /Source="Nicolas_upshifts" /id="U41" /multdbtbs="-" /comp="M11" /sig="Sig-" /pcomp="0.48051948051948" /psig="0.48051948051948" /xcortree=100 /SigmaFactorBS="aaaaagtttcatgaatatacaaaagtttttattttgtcttgg aggaAATAATGAAAATTAAAGagatcattgtggtcgaggggcgtgacgatacggcccg c" /listShort="rnmV, ksgA" /GFF_Attribute="listLong" /label="upshifts" CDS 50231..51109 /gene="rsmA" /locus_tag="BSU_00420" /old_locus_tag="BSU00420" /EC_number="2.1.1.-" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 99430, 6801425, 11327780, 1690648, 22391551; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dimethyladenosine 16S ribosomal RNA transferase" /protein_id="NP_387923.1" /db_xref="EnsemblGenomes-Gn:BSU00420" /db_xref="EnsemblGenomes-Tr:CAB11818" /db_xref="GOA:P37468" /db_xref="InterPro:IPR001737" /db_xref="InterPro:IPR011530" /db_xref="InterPro:IPR020596" /db_xref="InterPro:IPR020598" /db_xref="InterPro:IPR023165" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG10105" /db_xref="UniProtKB/Swiss-Prot:P37468" /translation="MNKDIATPIRTKEILKKYGFSFKKSLGQNFLIDTNILNRIVDHA EVTEKTGVIEIGPGIGALTEQLAKRAKKVVAFEIDQRLLPILKDTLSPYENVTVIHQD VLKADVKSVIEEQFQDCDEIMVVANLPYYVTTPIIMKLLEEHLPLKGIVVMLQKEVAE RMAADPSSKEYGSLSIAVQFYTEAKTVMIVPKTVFVPQPNVDSAVIRLILRDGPAVDV ENESFFFQLIKASFAQRRKTLLNNLVNNLPEGKAQKSTIEQVLEETNIDGKRRGESLS IEEFAALSNGLYKALF*" /label="rsmA CDS" gene 50231..51109 /gene="rsmA" /locus_tag="BSU_00420" /old_locus_tag="BSU00420" /label="rsmA gene" downshifts 51074 /Source="Nicolas_upshifts" /id="D18" /incds=0 /nref=152 /ntot=229 /MaxReadThrough="3.0815" /MaxDrop="4.58632" /score="20.4155562" /energy="-9.4" /TU="NA" /idTUdmin="U36" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 51124..51133 /Source="Nicolas_upshift_promotors" /id="U42" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1303 /SigmaFactorBS="ttgtataaagcccttttctaaaagggctttttgttTTGCGCA CCAcatggactgccgcTACATAGGCTAGAGAAGGACctttcattcaatgataagaaaa a" /listShort="S28, yabG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 51147..51166 /Source="Nicolas_upshift_promotors" /id="U42" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1303 /SigmaFactorBS="ttgtataaagcccttttctaaaagggctttttgttTTGCGCA CCAcatggactgccgcTACATAGGCTAGAGAAGGACctttcattcaatgataagaaaa a" /listShort="S28, yabG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 51149..51270 /Source="Nicolas_S_feature" /locus_tag="new_51558_51679" /HighExp="S7, S6, S8, BT, S5, B36, G/S, Pyr, B60, Etha" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S28" upshifts 51149 /Source="Nicolas_upshifts" /id="U42" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1303 /SigmaFactorBS="ttgtataaagcccttttctaaaagggctttttgttTTGCGCA CCAcatggactgccgcTACATAGGCTAGAGAAGGACctttcattcaatgataagaaaa a" /listShort="S28, yabG" /GFF_Attribute="listLong" /label="upshifts" CDS 51271..52143 /gene="prtG" /locus_tag="BSU_00430" /old_locus_tag="BSU00430" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10714992, 11040425, 16751597, 19060142, 19833771" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10714992, 11040425, 16751597, 19060142, 19833771; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sporulation-specific protease" /protein_id="NP_387924.1" /db_xref="EnsemblGenomes-Gn:BSU00430" /db_xref="EnsemblGenomes-Tr:CAB11819" /db_xref="GOA:P37548" /db_xref="InterPro:IPR008764" /db_xref="SubtiList:BG10106" /db_xref="UniProtKB/Swiss-Prot:P37548" /translation="MQFQIGDMVARKSYQMDVLFRIIGIEQTSKGNSIAILHGDEVRL IADSDFSDLVAVKKDEQMMRKKKDESRMNESLELLRQDYKLLREKQEYYATSQYQHQE HYFHMPGKVLHLDGDEAYLKKCLNVYKKIGVPVYGIHCHEKKMSASIEVLLDKYRPDI LVITGHDAYSKQKGGIDDLNAYRHSKHFVETVQTARKKIPHLDQLVIFAGACQSHFES LIRAGANFASSPSRVNIHALDPVYIVAKISFTPFMERINVWEVLRNTLTREKGLGGIE TRGVLRIGMPYKSN*" /label="prtG CDS" gene 51271..52143 /gene="prtG" /locus_tag="BSU_00430" /old_locus_tag="BSU00430" /label="prtG gene" downshifts 52130 /Source="Nicolas_upshifts" /id="D19" /incds=0 /nref=15 /ntot=32 /MaxReadThrough="2.30424" /MaxDrop="7.1507" /score="26.6672651" /energy="-11.5" /TU="NA" /idTUdmin="U42" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 52240..52310 /Source="Nicolas_S_feature" /locus_tag="new_52649_52719" /HighExp="S8, S5, S7, S6, S4, BT, LoTm, G/S, nit, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S29" promotor_-35 52301..52308 /Source="Nicolas_upshift_promotors" /id="U43" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3089 /SigmaFactorBS="aaataattttattgacaacgtcttattaacgttgatataatt taaatttTATTTGACaaaaatgggctcgTGTTGTACAATAAATGTAGTgaggtggatg c" /listShort="veg, S30, sspF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 52312 /Source="Nicolas_upshifts" /id="U43" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3089 /SigmaFactorBS="aaataattttattgacaacgtcttattaacgttgatataatt taaatttTATTTGACaaaaatgggctcgTGTTGTACAATAAATGTAGTgaggtggatg c" /listShort="veg, S30, sspF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 52322..52341 /Source="Nicolas_upshift_promotors" /id="U43" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3089 /SigmaFactorBS="aaataattttattgacaacgtcttattaacgttgatataatt taaatttTATTTGACaaaaatgggctcgTGTTGTACAATAAATGTAGTgaggtggatg c" /listShort="veg, S30, sspF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(52331..52345) /Source="Nicolas_upshift_promotors" /id="U44" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.996003996003996" /psig="0.000999000999001" /xcortree=718 /SigmaFactorBS="attcccatcaagcgatcttttaatatcggacaacgtcttcGC CATtgcatccaCCTCACTACATTTATtgtacaacacgagcccatttttgtcaaataaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(52338) /Source="Nicolas_upshifts" /id="U44" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.996003996003996" /psig="0.000999000999001" /xcortree=718 /SigmaFactorBS="attcccatcaagcgatcttttaatatcggacaacgtcttcGC CATtgcatccaCCTCACTACATTTATtgtacaacacgagcccatttttgtcaaataaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(52354..52358) /Source="Nicolas_upshift_promotors" /id="U44" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.996003996003996" /psig="0.000999000999001" /xcortree=718 /SigmaFactorBS="attcccatcaagcgatcttttaatatcggacaacgtcttcGC CATtgcatccaCCTCACTACATTTATtgtacaacacgagcccatttttgtcaaataaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 52354..52614 /gene="veg" /locus_tag="BSU_00440" /old_locus_tag="BSU00440" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12761295, 22720735, 23378512; Producttype ph: phenotype" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_387925.1" /db_xref="EnsemblGenomes-Gn:BSU00440" /db_xref="EnsemblGenomes-Tr:CAB11820" /db_xref="GOA:P37466" /db_xref="InterPro:IPR009366" /db_xref="SubtiList:BG10107" /db_xref="UniProtKB/Swiss-Prot:P37466" /translation="MAKTLSDIKRSLDGNLGKRLTLKANGGRRKTIERSGILAETYPS VFVIQLDQDENSFERVSYSYADILTETVELTFNDDAASSVAF*" /label="veg CDS" gene 52354..52614 /gene="veg" /locus_tag="BSU_00440" /old_locus_tag="BSU00440" /label="veg gene" downshifts 52526 /Source="Nicolas_upshifts" /id="D20" /incds=1 /nref=4 /ntot=158 /MaxReadThrough="8.09861" /MaxDrop="2.7867" /score="12.4853319" /energy="-9.9" /TU="U43" /idTUdmin="U42" /TUdmin=396 /isTUend="FALSE" /label="downshifts" downshifts 52613 /Source="Nicolas_upshifts" /id="D21" /incds=0 /nref=191 /ntot=264 /MaxReadThrough="5.88511" /MaxDrop="6.03144" /score="12.4853319" /energy="-9.9" /TU="U43" /idTUdmin="U43" /TUdmin="-331" /isTUend="FALSE" /label="downshifts" promotor_-35 52679..52685 /Source="Nicolas_upshift_promotors" /id="U45" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=844 /SigmaFactorBS="ttttgttttgcccttttttggtttccaataattttaaCGAAA GTtccatctgatttaACAAAAGATAAAacagtcacatattatcgtgacgtgcacgaat g" /listShort="S30, sspF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 52699..52710 /Source="Nicolas_upshift_promotors" /id="U45" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=844 /SigmaFactorBS="ttttgttttgcccttttttggtttccaataattttaaCGAAA GTtccatctgatttaACAAAAGATAAAacagtcacatattatcgtgacgtgcacgaat g" /listShort="S30, sspF" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 52702..52773 /Source="Nicolas_S_feature" /locus_tag="new_53111_53182" /HighExp="S8, Cold, S6, S7, ferm, S5, nit, Etha, G135, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigA" /TUshortPSig="0.96, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S30" upshifts 52702 /Source="Nicolas_upshifts" /id="U45" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=844 /SigmaFactorBS="ttttgttttgcccttttttggtttccaataattttaaCGAAA GTtccatctgatttaACAAAAGATAAAacagtcacatattatcgtgacgtgcacgaat g" /listShort="S30, sspF" /GFF_Attribute="listLong" /label="upshifts" CDS 52774..52959 /gene="sspF" /locus_tag="BSU_00450" /old_locus_tag="BSU00450" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7959056, 8982008, 11092849" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7959056, 8982008, 11092849; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein (alpha/beta-type SASP)" /protein_id="NP_387926.1" /db_xref="EnsemblGenomes-Gn:BSU00450" /db_xref="EnsemblGenomes-Tr:CAB11821" /db_xref="GOA:P37549" /db_xref="InterPro:IPR001448" /db_xref="InterPro:IPR018126" /db_xref="SubtiList:BG10108" /db_xref="UniProtKB/Swiss-Prot:P37549" /translation="MGRRRGVMSDEFKYELAKDLGFYDTVKNGGWGEIRARDAGNMVK RAIEIAEQQMAQNQNNR*" /label="sspF CDS" gene 52774..52959 /gene="sspF" /locus_tag="BSU_00450" /old_locus_tag="BSU00450" /label="sspF gene" downshifts 52944 /Source="Nicolas_upshifts" /id="D22" /incds=0 /nref=54 /ntot=153 /MaxReadThrough="2.67408" /MaxDrop="6.21058" /score="38.1065567" /energy="-12.6" /TU="NA" /idTUdmin="U43" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(52954..55308) /Source="Nicolas_S_feature" /locus_tag="new_53363_55717_c" /HighExp="S5, S4, S6, T5.0H, S3, S8, S7, T4.0H, T3.30H, C30" /AntisenseName="ispE" /AntisenseCor="-0.66604185700913698" /AntisenseRegPval="-35.1" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S31" promotor_-35 53037..53041 /Source="Nicolas_upshift_promotors" /id="U46" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.745254745254745" /psig=1 /xcortree=2586 /SigmaFactorBS="ttttggatataaatacataatgggctgaatatggataTGTTC atcctgtacttcaaaTGTGATACAATGTTCATACTtatgtttagatggagaagtaggt g" /listShort="ispE, purR, yabJ, S32" /listLong="spoVG" /label="promotor_-35" promotor_-10 53057..53076 /Source="Nicolas_upshift_promotors" /id="U46" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.745254745254745" /psig=1 /xcortree=2586 /SigmaFactorBS="ttttggatataaatacataatgggctgaatatggataTGTTC atcctgtacttcaaaTGTGATACAATGTTCATACTtatgtttagatggagaagtaggt g" /listShort="ispE, purR, yabJ, S32" /listLong="spoVG" /label="promotor_-10" upshifts 53060 /Source="Nicolas_upshifts" /id="U46" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.745254745254745" /psig=1 /xcortree=2586 /SigmaFactorBS="ttttggatataaatacataatgggctgaatatggataTGTTC atcctgtacttcaaaTGTGATACAATGTTCATACTtatgtttagatggagaagtaggt g" /listShort="ispE, purR, yabJ, S32" /listLong="spoVG" /label="upshifts" CDS 53107..53976 /gene="ispE" /locus_tag="BSU_00460" /old_locus_tag="BSU00460" /EC_number="2.7.1.148" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11361082, 12682299, 12771135, 17458547, 23840410; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase" /protein_id="NP_387927.1" /db_xref="EnsemblGenomes-Gn:BSU00460" /db_xref="EnsemblGenomes-Tr:CAB11822" /db_xref="GOA:P37550" /db_xref="InterPro:IPR004424" /db_xref="InterPro:IPR006204" /db_xref="InterPro:IPR013750" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR036554" /db_xref="SubtiList:BG10109" /db_xref="UniProtKB/Swiss-Prot:P37550" /translation="MRILEKAPAKINLSLDVTRKRPDGYHEVEMIMTTIDLADRIELT ELAEDEVRVSSHNRFVPDDQRNLAYQAAKLIKDRYNVKKGVSIMITKVIPVAAGLAGG SSDAAATLRGLNRLWNLNLSAETLAELGAEIGSDVSFCVYGGTALATGRGEKIKHIST PPHCWVILAKPTIGVSTAEVYRALKLDGIEHPDVQGMIEAIEEKSFQKMCSRLGNVLE SVTLDMHPEVAMIKNQMKRFGADAVLMSGSGPTVFGLVQYESKVQRIYNGLRGFCDQV YAVRMIGEQNALD*" /label="ispE CDS" gene 53107..53976 /gene="ispE" /locus_tag="BSU_00460" /old_locus_tag="BSU00460" /label="ispE gene" CDS 54032..54889 /gene="purR" /locus_tag="BSU_00470" /old_locus_tag="BSU00470" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11591660, 12837783, 12837784, 15629952, 16163456, 27329548" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11591660, 12837783, 12837784, 15629952, 16163456, 27329548; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of the purine biosynthesis operon (PurR-pRpp)" /protein_id="NP_387928.1" /db_xref="EnsemblGenomes-Gn:BSU00470" /db_xref="EnsemblGenomes-Tr:CAB11823" /db_xref="GOA:P37551" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR010078" /db_xref="InterPro:IPR015265" /db_xref="InterPro:IPR029057" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:1O57" /db_xref="PDB:1P4A" /db_xref="SubtiList:BG10110" /db_xref="UniProtKB/Swiss-Prot:P37551" /translation="MKFRRSGRLVDLTNYLLTHPHELIPLTFFSERYESAKSSISEDL TIIKQTFEQQGIGTLLTVPGAAGGVKYIPKMKQAEAEEFVQTLGQSLANPERILPGGY VYLTDILGKPSVLSKVGKLFASVFAEREIDVVMTVATKGIPLAYAAASYLNVPVVIVR KDNKVTEGSTVSINYVSGSSNRIQTMSLAKRSMKTGSNVLIIDDFMKAGGTINGMINL LDEFNANVAGIGVLVEAEGVDERLVDEYMSLLTLSTINMKEKSIEIQNGNFLRFFKDN LLKNGETES*" /label="purR CDS" gene 54032..54889 /gene="purR" /locus_tag="BSU_00470" /old_locus_tag="BSU00470" /label="purR gene" CDS 54886..55263 /gene="ridA" /locus_tag="BSU_00480" /old_locus_tag="BSU00480" /EC_number="3.5.99.10" /function="16.6: Maintain" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2113912, 12515541, 14729707, 10557275, 10919400, 10368157, 20562306, 23815688; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aminoacrylate/iminopropionate hydrolase/deaminase" /protein_id="NP_387929.1" /db_xref="EnsemblGenomes-Gn:BSU00480" /db_xref="EnsemblGenomes-Tr:CAB11824" /db_xref="GOA:P37552" /db_xref="InterPro:IPR006056" /db_xref="InterPro:IPR006175" /db_xref="InterPro:IPR019897" /db_xref="InterPro:IPR035959" /db_xref="PDB:1QD9" /db_xref="SubtiList:BG10111" /db_xref="UniProtKB/Swiss-Prot:P37552" /translation="MTKAVHTKHAPAAIGPYSQGIIVNNMFYSSGQIPLTPSGEMVNG DIKEQTHQVFSNLKAVLEEAGASFETVVKATVFIADMEQFAEVNEVYGQYFDTHKPAR SCVEVARLPKDALVEIEVIALVK*" /label="ridA CDS" gene 54886..55263 /gene="ridA" /locus_tag="BSU_00480" /old_locus_tag="BSU00480" /label="ridA gene" downshifts 55253 /Source="Nicolas_upshifts" /id="D23" /incds=0 /nref=172 /ntot=226 /MaxReadThrough="3.8891" /MaxDrop="4.63425" /score="22.9159767" /energy="-12.3" /TU="U46" /idTUdmin="U46" /TUdmin="-155" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(55297..55315) /Source="Nicolas_upshift_promotors" /id="U47" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1146 /SigmaFactorBS="ttttgaaaaaataggatatagttacacaattagGTCATAaag ctttcatttcggGCATAAGGTAAATAAAAAAgtgatcccggctctcccagaatcactt t" /listShort="S31" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 55298..55406 /Source="Nicolas_S_feature" /locus_tag="new_55707_55815" /HighExp="S8, S7, Etha, B36, LoTm, C30, Sw, B60, G135, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S32" upshifts complement(55309) /Source="Nicolas_upshifts" /id="U47" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1146 /SigmaFactorBS="ttttgaaaaaataggatatagttacacaattagGTCATAaag ctttcatttcggGCATAAGGTAAATAAAAAAgtgatcccggctctcccagaatcactt t" /listShort="S31" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(55331..55336) /Source="Nicolas_upshift_promotors" /id="U47" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1146 /SigmaFactorBS="ttttgaaaaaataggatatagttacacaattagGTCATAaag ctttcatttcggGCATAAGGTAAATAAAAAAgtgatcccggctctcccagaatcactt t" /listShort="S31" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 55386..55394 /Source="Nicolas_upshift_promotors" /id="U48" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=524 /SigmaFactorBS="actatatcctattttttcaaaaaatattttaaaaacgaGCAG GATTTcagaaaaaatCGTGGAATTGATACACTAAtgcttttatatagggaaaaggtgg t" /listShort="spoVG, S33, gcaD, prs" /listLong="ctc, pth, yabK, S34, mfd, S35, spoVT" /label="promotor_-35" promotor_-10 55405..55423 /Source="Nicolas_upshift_promotors" /id="U48" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=524 /SigmaFactorBS="actatatcctattttttcaaaaaatattttaaaaacgaGCAG GATTTcagaaaaaatCGTGGAATTGATACACTAAtgcttttatatagggaaaaggtgg t" /listShort="spoVG, S33, gcaD, prs" /listLong="ctc, pth, yabK, S34, mfd, S35, spoVT" /label="promotor_-10" upshifts 55408 /Source="Nicolas_upshifts" /id="U48" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=524 /SigmaFactorBS="actatatcctattttttcaaaaaatattttaaaaacgaGCAG GATTTcagaaaaaatCGTGGAATTGATACACTAAtgcttttatatagggaaaaggtgg t" /listShort="spoVG, S33, gcaD, prs" /listLong="ctc, pth, yabK, S34, mfd, S35, spoVT" /label="upshifts" CDS 55457..55750 /gene="spoVG" /locus_tag="BSU_00490" /old_locus_tag="BSU00490" /function="16.3: Control" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9733708, 10348850, 10648512, 16428420, 27048798" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9733708, 10348850, 10648512, 16428420, 27048798; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator required for spore cortex synthesis (stage V sporulation)" /protein_id="NP_387930.1" /db_xref="EnsemblGenomes-Gn:BSU00490" /db_xref="EnsemblGenomes-Tr:CAB11825" /db_xref="GOA:P28015" /db_xref="InterPro:IPR007170" /db_xref="InterPro:IPR036751" /db_xref="PDB:2IA9" /db_xref="SubtiList:BG10112" /db_xref="UniProtKB/Swiss-Prot:P28015" /translation="MEVTDVRLRRVNTDGRMRAIASITLDHEFVVHDIRVIDGNNGLF VAMPSKRTPDGEFRDITHPINSSTRGKIQDAVLNEYHRLGDTEALEFEEAGAS*" /label="spoVG CDS" gene 55457..55750 /gene="spoVG" /locus_tag="BSU_00490" /old_locus_tag="BSU00490" /label="spoVG gene" downshifts 55739 /Source="Nicolas_upshifts" /id="D24" /incds=0 /nref=263 /ntot=285 /MaxReadThrough="5.11673" /MaxDrop="7.2673" /score="19.392304" /energy="-22.3" /TU="U48" /idTUdmin="U46" /TUdmin=331 /isTUend="FALSE" /label="downshifts" S_feature 55784..55895 /Source="Nicolas_S_feature" /locus_tag="new_56193_56304" /HighExp="B60, B36, M9-stat, S2, BT, LoTm, Etha, Lbstat, T0.30H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S33" promotor_-35 55877..55881 /Source="Nicolas_upshift_promotors" /id="U49" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.895104895104895" /psig="0.996003996003996" /xcortree=2611 /SigmaFactorBS="agttgcactcaatagaaaattcttgcacttcatgaagtctCC TTGaaatcagaagatattTAGGATATATTTTTCTATGGataaaagggatattggaggc c" /listShort="gcaD, prs, ctc, pth, yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 55897..55916 /Source="Nicolas_upshift_promotors" /id="U49" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.895104895104895" /psig="0.996003996003996" /xcortree=2611 /SigmaFactorBS="agttgcactcaatagaaaattcttgcacttcatgaagtctCC TTGaaatcagaagatattTAGGATATATTTTTCTATGGataaaagggatattggaggc c" /listShort="gcaD, prs, ctc, pth, yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 55897 /Source="Nicolas_upshifts" /id="U49" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.895104895104895" /psig="0.996003996003996" /xcortree=2611 /SigmaFactorBS="agttgcactcaatagaaaattcttgcacttcatgaagtctCC TTGaaatcagaagatattTAGGATATATTTTTCTATGGataaaagggatattggaggc c" /listShort="gcaD, prs, ctc, pth, yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="upshifts" CDS 55943..57313 /gene="glmU" /locus_tag="BSU_00500" /old_locus_tag="BSU00500" /EC_number="2.3.1.157" /EC_number="2.7.7.23" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1328164, 8522540, 9648743, 11124906, 20495944, 23485416, 24915076" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1328164, 8522540, 9648743, 11124906, 20495944, 23485416, 24915076; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional glucosamine-1-phosphate N-acetyltransferase/UDP-N-acetylglucosamine pyrophosphorylase" /protein_id="NP_387931.1" /db_xref="EnsemblGenomes-Gn:BSU00500" /db_xref="EnsemblGenomes-Tr:CAB11826" /db_xref="GOA:P14192" /db_xref="InterPro:IPR001451" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR005882" /db_xref="InterPro:IPR011004" /db_xref="InterPro:IPR018357" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10113" /db_xref="UniProtKB/Swiss-Prot:P14192" /translation="MDKRFAVVLAAGQGTRMKSKLYKVLHPVCGKPMVEHVVDEALKL SLSKLVTIVGHGAEEVKKQLGDKSEYALQAKQLGTAHAVKQAQPFLADEKGVTIVICG DTPLLTAETMEQMLKEHTQREAKATILTAVAEDPTGYGRIIRSENGAVQKIVEHKDAS EEERLVTEINTGTYCFDNEALFRAIDQVSNDNAQGEYYLPDVIEILKNEGETVAAYQT GNFQETLGVNDRVALSQAEQFMKERINKRHMQNGVTLIDPMNTYISPDAVIGSDTVIY PGTVIKGEVQIGEDTIIGPHTEIMNSAIGSRTVIKQSVVNHSKVGNDVNIGPFAHIRP DSVIGNEVKIGNFVEIKKTQFGDRSKASHLSYVGDAEVGTDVNLGCGSITVNYDGKNK YLTKIEDGAFIGCNSNLVAPVTVGEGAYVAAGSTVTEDVPGKALAIARARQVNKDDYV KNIHKK*" /label="glmU CDS" gene 55943..57313 /gene="glmU" /locus_tag="BSU_00500" /old_locus_tag="BSU00500" /label="glmU gene" downshifts complement(57288) /Source="Nicolas_upshifts" /id="D25" /incds=0 /nref=5 /ntot=84 /MaxReadThrough="2.39379" /MaxDrop="3.65636" /score="-7.65702938" /energy="-13.8" /TU="NA" /idTUdmin="U47" /TUdmin="-4312" /isTUend="FALSE" /label="downshifts" CDS 57336..58289 /gene="prs" /locus_tag="BSU_00510" /old_locus_tag="BSU00510" /EC_number="2.7.6.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2169413, 3038693, 8522540, 22083279, 25890046" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2169413, 3038693, 8522540, 22083279, 25890046; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylpyrophosphate synthetase" /protein_id="NP_387932.1" /db_xref="EnsemblGenomes-Gn:BSU00510" /db_xref="EnsemblGenomes-Tr:CAB11827" /db_xref="GOA:P14193" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR000842" /db_xref="InterPro:IPR005946" /db_xref="InterPro:IPR029057" /db_xref="InterPro:IPR029099" /db_xref="PDB:1DKR" /db_xref="PDB:1DKU" /db_xref="PDB:1IBS" /db_xref="SubtiList:BG10114" /db_xref="UniProtKB/Swiss-Prot:P14193" /translation="MSNQYGDKNLKIFSLNSNPELAKEIADIVGVQLGKCSVTRFSDG EVQINIEESIRGCDCYIIQSTSDPVNEHIMELLIMVDALKRASAKTINIVIPYYGYAR QDRKARSREPITAKLFANLLETAGATRVIALDLHAPQIQGFFDIPIDHLMGVPILGEY FEGKNLEDIVIVSPDHGGVTRARKLADRLKAPIAIIDKRRPRPNVAEVMNIVGNIEGK TAILIDDIIDTAGTITLAANALVENGAKEVYACCTHPVLSGPAVERINNSTIKELVVT NSIKLPEEKKIERFKQLSVGPLLAEAIIRVHEQQSVSYLFS*" /label="prs CDS" gene 57336..58289 /gene="prs" /locus_tag="BSU_00510" /old_locus_tag="BSU00510" /label="prs gene" promotor_-35 58302..58308 /Source="Nicolas_upshift_promotors" /id="U50" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=265 /SigmaFactorBS="agcaatcagtcagctatctgttcagctaaaccatttttcgaG GTTTAAatccttatcgttatGGGTATTGTTTGTAATAGGacaactaaaacgacaagag g" /listShort="ctc, pth, yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 58321 /Source="Nicolas_upshifts" /id="U50" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=265 /SigmaFactorBS="agcaatcagtcagctatctgttcagctaaaccatttttcgaG GTTTAAatccttatcgttatGGGTATTGTTTGTAATAGGacaactaaaacgacaagag g" /listShort="ctc, pth, yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 58323..58341 /Source="Nicolas_upshift_promotors" /id="U50" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=265 /SigmaFactorBS="agcaatcagtcagctatctgttcagctaaaccatttttcgaG GTTTAAatccttatcgttatGGGTATTGTTTGTAATAGGacaactaaaacgacaagag g" /listShort="ctc, pth, yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="promotor_-10" CDS 58374..58988 /gene="ctc" /locus_tag="BSU_00520" /old_locus_tag="BSU00520" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8522540, 9669336, 10369900, 12432960, 17198710" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8522540, 9669336, 10369900, 12432960, 17198710; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosomal protein BL25 (Ctc), binding 5S RNA" /protein_id="NP_387933.1" /db_xref="EnsemblGenomes-Gn:BSU00520" /db_xref="EnsemblGenomes-Tr:CAB11828" /db_xref="GOA:P14194" /db_xref="InterPro:IPR001021" /db_xref="InterPro:IPR011035" /db_xref="InterPro:IPR020056" /db_xref="InterPro:IPR020057" /db_xref="InterPro:IPR029751" /db_xref="InterPro:IPR037121" /db_xref="SubtiList:BG10115" /db_xref="UniProtKB/Swiss-Prot:P14194" /translation="MATLTAKERTDFTRSSLRNIRTSGHVPGIIYGKDTGNKPVSLDS VELIKTLRDEGKNAVITLEVSGEKHSVMVTDLQTDPLKNEITHADFQVVNMSEDIEVE VPIHLTGEAIGVKNGGVLQQPLYALTVKAKPKAIPQTIEADISSLDVNEVLTIADLPA GGDYSFNHESDEVVASILPPQQQEAAEVDEEESADAQPEGENEQ*" /label="ctc CDS" gene 58374..58988 /gene="ctc" /locus_tag="BSU_00520" /old_locus_tag="BSU00520" /label="ctc gene" downshifts 58972 /Source="Nicolas_upshifts" /id="D26" /incds=0 /nref=120 /ntot=249 /MaxReadThrough="8.65206" /MaxDrop="5.4784" /score="1.94770319" /energy="-11.2" /TU="U49,U50" /idTUdmin="U48" /TUdmin=682 /isTUend="FALSE" /label="downshifts" CDS 59095..59661 /gene="pth" /locus_tag="BSU_00530" /old_locus_tag="BSU00530" /EC_number="3.1.1.29" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:8635758, 12100553, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8635758, 12100553, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptidyl-tRNA hydrolase" /protein_id="NP_387934.1" /db_xref="EnsemblGenomes-Gn:BSU00530" /db_xref="EnsemblGenomes-Tr:CAB11829" /db_xref="GOA:P37470" /db_xref="InterPro:IPR001328" /db_xref="InterPro:IPR018171" /db_xref="InterPro:IPR036416" /db_xref="SubtiList:BG10116" /db_xref="UniProtKB/Swiss-Prot:P37470" /translation="MLVIAGLGNPGKNYENTRHNVGFMVIDQLAKEWNIELNQNKFNG LYGTGFVSGKKVLLVKPLTYMNLSGECLRPLMDYYDVDNEDLTVIYDDLDLPTGKIRL RTKGSAGGHNGIKSLIQHLGTSEFDRIRIGIGRPVNGMKVVDYVLGSFTKEEAPEIEE AVDKSVKACEASLSKPFLEVMNEFNAKV*" /label="pth CDS" gene 59095..59661 /gene="pth" /locus_tag="BSU_00530" /old_locus_tag="BSU00530" /label="pth gene" misc_feature 59274..59277 /Source="Nicolas_upshift_promotors" /id="U51" /multdbtbs="-" /comp="M11" /sig="Sig-" /pcomp="0.210789210789211" /psig="0.210789210789211" /xcortree=737 /SigmaFactorBS="taacggattatacggaaccggatttgtttccggcaaaaaggt tctacttgttaaACCGcttacatatatgaatttatcaggagaatgtttgcggccttta a" /listShort="yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 59280 /Source="Nicolas_upshifts" /id="U51" /multdbtbs="-" /comp="M11" /sig="Sig-" /pcomp="0.210789210789211" /psig="0.210789210789211" /xcortree=737 /SigmaFactorBS="taacggattatacggaaccggatttgtttccggcaaaaaggt tctacttgttaaACCGcttacatatatgaatttatcaggagaatgtttgcggccttta a" /listShort="yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="upshifts" CDS 59721..59951 /gene="fin" /locus_tag="BSU_00540" /old_locus_tag="BSU00540" /experiment="publication(s) with functional evidences, PMID:21037003, 28598017" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21037003, 28598017; Product type f: factor" /codon_start=1 /transl_table=11 /product="protein required for the switch from F to G during sporulation (anti sigma F)" /protein_id="NP_387935.1" /db_xref="EnsemblGenomes-Gn:BSU00540" /db_xref="EnsemblGenomes-Tr:CAB11830" /db_xref="GOA:P37553" /db_xref="InterPro:IPR020115" /db_xref="PDB:5MSL" /db_xref="SubtiList:BG10117" /db_xref="UniProtKB/Swiss-Prot:P37553" /translation="MALHYYCRHCGVKVGSLESSMVSTDSLGFQHLTNEERNDMISYK ENGDVHVLTICEDCQEALDRNPHYHEYHTFIQ*" /label="fin CDS" gene 59721..59951 /gene="fin" /locus_tag="BSU_00540" /old_locus_tag="BSU00540" /label="fin gene" S_feature 59952..60020 /Source="Nicolas_S_feature" /locus_tag="new_60361_60429" /HighExp="Etha, S5, S4, S7, S8, S6, S3, H2O2, Diami, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigB, SigA" /TUshortPSig="0.211, 1, 0.996" /TUlongSig="SigH" /TUlongPSig=1 /label="S34" CDS 60021..63554 /gene="mfd" /locus_tag="BSU_00550" /old_locus_tag="BSU00550" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8594198, 9535092, 11065368, 16950921, 22248542, 25713353, 27399782, 27435260" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8594198, 9535092, 11065368, 16950921, 22248542, 25713353, 27399782, 27435260; Product type f: factor" /codon_start=1 /transl_table=11 /product="transcription-repair coupling factor" /protein_id="NP_387936.1" /db_xref="EnsemblGenomes-Gn:BSU00550" /db_xref="EnsemblGenomes-Tr:CAB11831" /db_xref="GOA:P37474" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR003711" /db_xref="InterPro:IPR004576" /db_xref="InterPro:IPR005118" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036101" /db_xref="SubtiList:BG10118" /db_xref="UniProtKB/Swiss-Prot:P37474" /translation="MDNIQTFIKESDDFKSIINGLHEGLKEQLLAGLSGSARSVFTSA LANETNKPIFLITHNLYQAQKVTDDLTSLLEDRSVLLYPVNELISSEIAVASPELRAQ RLDVINRLTNGEAPIVVAPVAAIRRMLPPVEVWKSSQMLIQVGHDIEPDQLASRLVEV GYERSDMVSAPGEFSIRGGIIDIYPLTSENPVRIELFDTEVDSIRSFNSDDQRSIETL TSINIGPAKELIIRPEEKARAMEKIDSGLAASLKKLKADKQKEILHANISHDKERLSE GQTDQELVKYLSYFYEKPASLLDYTPDNTLLILDEVSRIHEMEEQLQKEEAEFITNLL EEGKILHDIRLSFSFQKIVAEQKRPLLYYSLFLRHVHHTSPQNIVNVSGRQMQSFHGQ MNVLAGEMERFKKSNFTVVFLGANKERTQKLSSVLADYDIEAAMTDSKKALVQGQVYI MEGELQSGFELPLMKLAVITEEELFKNRVKKKPRKQKLTNAERIKSYSELQIGDYVVH INHGIGKYLGIETLEINGIHKDYLNIHYQGSDKLYVPVEQIDQVQKYVGSEGKEPKLY KLGGSEWKRVKKKVETSVQDIADDLIKLYAEREASKGYAFSPDHEMQREFESAFPYQE TEDQLRSIHEIKKDMERERPMDRLLCGDVGYGKTEVAIRAAFKAIGDGKQVALLVPTT ILAQQHYETIKERFQDYPINIGLLSRFRTRKEANETIKGLKNGTVDIVIGTHRLLSKD VVYKDLGLLIIDEEQRFGVTHKEKIKQIKANVDVLTLTATPIPRTLHMSMLGVRDLSV IETPPENRFPVQTYVVEYNGALVREAIERELARGGQVYFLYNRVEDIERKADEISMLV PDAKVAYAHGKMTENELETVMLSFLEGESDVLVSTTIIETGVDIPNVNTLIVFDADKM GLSQLYQLRGRVGRSNRVAYAYFTYRRDKVLTEVAEKRLQAIKEFTELGSGFKIAMRD LTIRGAGNLLGAQQHGFIDSVGFDLYSQMLKEAIEERKGDTAKTEQFETEIDVELDAY IPETYIQDGKQKIDMYKRFRSVATIEEKNELQDEMIDRFGNYPKEVEYLFTVAEMKVY ARQERVELIKQDKDAVRLTISEEASAEIDGQKLFELGNQYGRQIGLGMEGKKLKISIQ TKGRSADEWLDTVLGMLKGLKDVKKQTISST*" /label="mfd CDS" gene 60021..63554 /gene="mfd" /locus_tag="BSU_00550" /old_locus_tag="BSU00550" /label="mfd gene" promotor_-35 63572..63578 /Source="Nicolas_upshift_promotors" /id="U52" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=914 /SigmaFactorBS="agcaaaccatttcatcaacgtaaattttgttactctctggTG TATATtacatttgatgtgACGGATACTAATttcaagcgaggcggaaggtacataaagt a" /listShort="S35, spoVT" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 63592..63689 /Source="Nicolas_S_feature" /locus_tag="new_64001_64098" /HighExp="S5, S7, S8, S6, S4, Etha, S3, H2O2, G135, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, Sig-, SigB, SigA" /TUshortPSig="1, 0.211, 1, 0.996" /TUlongSig="SigH" /TUlongPSig=1 /label="S35" promotor_-10 63592..63603 /Source="Nicolas_upshift_promotors" /id="U52" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=914 /SigmaFactorBS="agcaaaccatttcatcaacgtaaattttgttactctctggTG TATATtacatttgatgtgACGGATACTAATttcaagcgaggcggaaggtacataaagt a" /listShort="S35, spoVT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 63592 /Source="Nicolas_upshifts" /id="U52" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=914 /SigmaFactorBS="agcaaaccatttcatcaacgtaaattttgttactctctggTG TATATtacatttgatgtgACGGATACTAATttcaagcgaggcggaaggtacataaagt a" /listShort="S35, spoVT" /GFF_Attribute="listLong" /label="upshifts" CDS 63690..64226 /gene="spoVT" /locus_tag="BSU_00560" /old_locus_tag="BSU00560" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8755877, 15063493, 15939023, 16159768, 18996130, 22522895, 27790204" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8755877, 15063493, 15939023, 16159768, 18996130, 22522895, 27790204; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of sporulation / germination" /protein_id="NP_387937.1" /db_xref="EnsemblGenomes-Gn:BSU00560" /db_xref="EnsemblGenomes-Tr:CAB11832" /db_xref="GOA:P37554" /db_xref="InterPro:IPR007159" /db_xref="InterPro:IPR014213" /db_xref="PDB:2RO5" /db_xref="PDB:2W1R" /db_xref="PDB:2W1T" /db_xref="SubtiList:BG10119" /db_xref="UniProtKB/Swiss-Prot:P37554" /translation="MKATGIVRRIDDLGRVVIPKEIRRTLRIREGDPLEIFVDRDGEV ILKKYSPISELGDFAKEYADALYDSLGHSVLICDRDVYIAVSGSSKKDYLNKSISEML ERTMDQRSSVLESDAKSVQLVNGIDEDMNSYTVGPIVANGDPIGAVVIFSKDQTMGEV EHKAVETAAGFLARQMEQ*" /label="spoVT CDS" gene 63690..64226 /gene="spoVT" /locus_tag="BSU_00560" /old_locus_tag="BSU00560" /label="spoVT gene" downshifts 64230 /Source="Nicolas_upshifts" /id="D27" /incds=0 /nref=236 /ntot=260 /MaxReadThrough="1.92082" /MaxDrop="6.20706" /score="-2.69593259" /energy="-11.6" /TU="NA" /idTUdmin="U49" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature 64326..64345 /Source="Nicolas_upshift_promotors" /id="U53" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.946053946053946" /psig=1 /xcortree=1839 /SigmaFactorBS="gacgctgttctttttcatgcgtgccgaaaaaggaatccaagg gttgggaTGTGGTATAATAACCTCGTTtttatttgtgccgcggtaatacgtgaaccgt a" /listShort="yabM, yabN, yabO, yabP, yabQ, divIC, yabR" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 64337 /Source="Nicolas_upshifts" /id="U53" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.946053946053946" /psig=1 /xcortree=1839 /SigmaFactorBS="gacgctgttctttttcatgcgtgccgaaaaaggaatccaagg gttgggaTGTGGTATAATAACCTCGTTtttatttgtgccgcggtaatacgtgaaccgt a" /listShort="yabM, yabN, yabO, yabP, yabQ, divIC, yabR" /GFF_Attribute="listLong" /label="upshifts" CDS 64408..66006 /gene="yabM" /locus_tag="BSU_00570" /old_locus_tag="BSU00570" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative exporter" /protein_id="NP_387938.1" /db_xref="EnsemblGenomes-Gn:BSU00570" /db_xref="EnsemblGenomes-Tr:CAB11833" /db_xref="GOA:P37555" /db_xref="InterPro:IPR002797" /db_xref="InterPro:IPR024923" /db_xref="InterPro:IPR029303" /db_xref="SubtiList:BG10120" /db_xref="UniProtKB/Swiss-Prot:P37555" /translation="MDDSIGVKRHWIWQGAFVLILAGVITKILSAVYRVPFQNIVGDV GFYIYQQVYPFLGIAVMLSTSGFPVIISKLMNDYSEKNHHTILKISALFLSLIGILLF LCLYLGAVPIALFMGDSHLAVLIQVAAYAFLLFPFVALLRGGFQGRHEMLPSALSQMT EQFLRVAVLLGLSFWLVKKGASLYTAGAAAASGSLAGSLVALIILGFFWFKTKRDNQT DRQNENVITTKELTKKLLLYSVTICVSSLLLLFIQLVDALNLYALLSGGEASEEAKCL KGIYDRGQPLLQLGSVFAVSIATSLVPYISMAVKNKELKIMKEKITSSLKLCLVLGTG ASAGLICILKPVNIMLFQNGEGTGALQVFSCSILFASLAVTAAAVLQGAGYTVFPAIA VGAGVAVKWVLNTLLVPRYGIEGASLATAASFAAVAGLNLYQLRQKEWLDKLRGVLIP IIGSALLMSAVLLAYTRLWTFLFPATGRGAAVIESLSAVAIGGAVFIYCMMRLGIFTD EELNSVPFGSKLSKFMRRREQNGG*" /label="yabM CDS" gene 64408..66006 /gene="yabM" /locus_tag="BSU_00570" /old_locus_tag="BSU00570" /label="yabM gene" promotor_-35 65877..65884 /Source="Nicolas_upshift_promotors" /id="U54" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.739260739260739" /psig="0.798201798201798" /xcortree=108 /SigmaFactorBS="gattgagagtctttctgctgttgcCATTGGTGgcgcggtgtt tattTATTGTATGATGAGATTGGGaatatttacagatgaagagctgaacagtgtgcca t" /listShort="yabN, yabO, yabP, yabQ" /listLong="divIC, yabR" /label="promotor_-35" promotor_-10 65899..65918 /Source="Nicolas_upshift_promotors" /id="U54" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.739260739260739" /psig="0.798201798201798" /xcortree=108 /SigmaFactorBS="gattgagagtctttctgctgttgcCATTGGTGgcgcggtgtt tattTATTGTATGATGAGATTGGGaatatttacagatgaagagctgaacagtgtgcca t" /listShort="yabN, yabO, yabP, yabQ" /listLong="divIC, yabR" /label="promotor_-10" upshifts 65913 /Source="Nicolas_upshifts" /id="U54" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.739260739260739" /psig="0.798201798201798" /xcortree=108 /SigmaFactorBS="gattgagagtctttctgctgttgcCATTGGTGgcgcggtgtt tattTATTGTATGATGAGATTGGGaatatttacagatgaagagctgaacagtgtgcca t" /listShort="yabN, yabO, yabP, yabQ" /listLong="divIC, yabR" /label="upshifts" CDS 65996..67465 /gene="yabN" /locus_tag="BSU_00580" /old_locus_tag="BSU00580" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11178267; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative fusion methylase and nucleotide pyrophosphohydrolase" /protein_id="NP_387939.1" /db_xref="EnsemblGenomes-Gn:BSU00580" /db_xref="EnsemblGenomes-Tr:CAB11834" /db_xref="GOA:P37556" /db_xref="InterPro:IPR000878" /db_xref="InterPro:IPR004518" /db_xref="InterPro:IPR011551" /db_xref="InterPro:IPR014777" /db_xref="InterPro:IPR024180" /db_xref="InterPro:IPR035013" /db_xref="InterPro:IPR035996" /db_xref="SubtiList:BG10121" /db_xref="UniProtKB/Swiss-Prot:P37556" /translation="MAGKITVVGLGAGDMDQLTIGIHKLLTKADTLYVRTKDHPLIEE LEKETKNIRFFDDIYEKHDQFEAVYEEIADILFEAARREDVVYAVPGHPFVAEKTVQL LTERQEKENVQVKVAGGQSFLDATFNVLQIDPIEGFQFVDAGTLSADELELRHHLIIC QVYDQMTASEVKLTLMEKLPDDYEVVIVTAAGSRGEEIRTVPLFELDRNVALNNLTSV YIPPIKEEKLLYHEFSTFRSIIRELRGPNGCPWDKKQTHQSLKQYMIEECYELLEAID EEDTDHMIEELGDVLLQVLLHAQIGEDEGYFTIDDVIKGISEKMVRRHPHVFKDVKVQ DENDVLANWEDIKKAEKNTSESSLLDSVPKTLPALSKAAKLQKKAAKVGFDWEDVSDI WEKVSEEMKEFSSEVSEAPHEHNLKAEFGDILFALVNVARFYKIEPEEALTMTNDKFR RRFSYIEETAKEEGVELADMSLEDMDKLWNEAKETERRS*" /label="yabN CDS" gene 65996..67465 /gene="yabN" /locus_tag="BSU_00580" /old_locus_tag="BSU00580" /label="yabN gene" promotor_-35 66637..66644 /Source="Nicolas_upshift_promotors" /id="U55" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2822 /SigmaFactorBS="tggaccgcaatgtcgctttgaacaaCTTAACAAgtgtgtata ttccGCCGATTAAAGAAGAGAAGctgctttatcacgaattctccacgttccgaagcat c" /listShort="yabO, yabP, yabQ, divIC, yabR" /listLong="trnSL-Met1" /label="promotor_-35" promotor_-10 66658..66676 /Source="Nicolas_upshift_promotors" /id="U55" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2822 /SigmaFactorBS="tggaccgcaatgtcgctttgaacaaCTTAACAAgtgtgtata ttccGCCGATTAAAGAAGAGAAGctgctttatcacgaattctccacgttccgaagcat c" /listShort="yabO, yabP, yabQ, divIC, yabR" /listLong="trnSL-Met1" /label="promotor_-10" upshifts 66672 /Source="Nicolas_upshifts" /id="U55" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2822 /SigmaFactorBS="tggaccgcaatgtcgctttgaacaaCTTAACAAgtgtgtata ttccGCCGATTAAAGAAGAGAAGctgctttatcacgaattctccacgttccgaagcat c" /listShort="yabO, yabP, yabQ, divIC, yabR" /listLong="trnSL-Met1" /label="upshifts" promotor_no_box complement(67060..67160) /Source="Nicolas_upshift_promotors" /id="U56" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.984015984015984" /psig="0.001998001998002" /xcortree=37 /SigmaFactorBS="cgtcttcccagtcaaaaccgaccttcgctgcttttttctgca atttagctgctttcgaaagagctggaagggttttcggtacgctgtctagtaatgatga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(67100) /Source="Nicolas_upshifts" /id="U56" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.984015984015984" /psig="0.001998001998002" /xcortree=37 /SigmaFactorBS="cgtcttcccagtcaaaaccgaccttcgctgcttttttctgca atttagctgctttcgaaagagctggaagggttttcggtacgctgtctagtaatgatga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 67468..67728 /gene="hslR" /locus_tag="BSU_00590" /old_locus_tag="BSU00590" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10675343, 10675344, 19013177; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosomal RNA binding protein involved in 50S recycling; heat shock protein" /protein_id="NP_387940.1" /db_xref="EnsemblGenomes-Gn:BSU00590" /db_xref="EnsemblGenomes-Tr:CAB11835" /db_xref="GOA:P37557" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR025490" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG10122" /db_xref="UniProtKB/Swiss-Prot:P37557" /translation="MRLDKFLKVSRLIKRRTLAKEVADQGRISINGNQAKASSDVKPG DELTVRFGQKLVTVQVNELKDTTKKEEAANMYTILKEEKLGE*" /label="hslR CDS" gene 67468..67728 /gene="hslR" /locus_tag="BSU_00590" /old_locus_tag="BSU00590" /label="hslR gene" promotor_-35 67733..67738 /Source="Nicolas_upshift_promotors" /id="U57" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1397 /SigmaFactorBS="aaaaactcggcgaataggcttGTTCTAaaaaaaccccccacc TCATACAATGCAGTAATAAtgctaaaagtatcgaggatatgggggctgaatagatgaa t" /listShort="yabP, yabQ, divIC, yabR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 67754..67772 /Source="Nicolas_upshift_promotors" /id="U57" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1397 /SigmaFactorBS="aaaaactcggcgaataggcttGTTCTAaaaaaaccccccacc TCATACAATGCAGTAATAAtgctaaaagtatcgaggatatgggggctgaatagatgaa t" /listShort="yabP, yabQ, divIC, yabR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 67772 /Source="Nicolas_upshifts" /id="U57" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1397 /SigmaFactorBS="aaaaactcggcgaataggcttGTTCTAaaaaaaccccccacc TCATACAATGCAGTAATAAtgctaaaagtatcgaggatatgggggctgaatagatgaa t" /listShort="yabP, yabQ, divIC, yabR" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(67804) /Source="Nicolas_upshifts" /id="D28" /incds=0 /nref=3 /ntot=19 /MaxReadThrough="1.93659" /MaxDrop="3.17193" /score="-0.425236437" /energy="-13.9" /TU="NA" /idTUdmin="U62" /TUdmin=3014 /isTUend="FALSE" /label="downshifts" CDS 67807..68109 /gene="spcP" /locus_tag="BSU_00600" /old_locus_tag="BSU00600" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10869437, 11283287, 15231775, 21904870, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10869437, 11283287, 15231775, 21904870, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="spore protein involved in the shaping of the spore coat" /protein_id="NP_387941.1" /db_xref="EnsemblGenomes-Gn:BSU00600" /db_xref="EnsemblGenomes-Tr:CAB11836" /db_xref="GOA:P37558" /db_xref="InterPro:IPR012504" /db_xref="InterPro:IPR022476" /db_xref="SubtiList:BG10123" /db_xref="UniProtKB/Swiss-Prot:P37558" /translation="MNSYYDQKGSSSVPEQHDVTMKGRKHLDISGVKHVESFDNEEFL LETVMGMLSVRGQNLQMKNLDVEKGIVSIKGRVFDLVYLDEQQGDKAKGFFSKLFK*" /label="spcP CDS" gene 67807..68109 /gene="spcP" /locus_tag="BSU_00600" /old_locus_tag="BSU00600" /label="spcP gene" CDS 68106..68741 /gene="spcQ" /locus_tag="BSU_00610" /old_locus_tag="BSU00610" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10869437, 11283287, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10869437, 11283287, 15849754, 16850406; Product type f: factor" /codon_start=1 /transl_table=11 /product="membrane protein of the forespore" /protein_id="NP_387942.1" /db_xref="EnsemblGenomes-Gn:BSU00610" /db_xref="EnsemblGenomes-Tr:CAB11837" /db_xref="GOA:P37559" /db_xref="InterPro:IPR014242" /db_xref="InterPro:IPR019074" /db_xref="SubtiList:BG10124" /db_xref="UniProtKB/Swiss-Prot:P37559" /translation="MTLTTQFYTMLAMSGMGLWLGASLDTYRLFVIRAKTARWLLFIH DILFWIMQGLLFFYVLLHVNEGEFRIYIFLAVLLGVATYQSLCKRIYIKILKFVIYLV VSVYQFFKKLIQHVLFRPIVWTCGAIIWLAAFLFKKTYSLIGFLLLCLYKIVMVLCFP IRFIAKQCLKLLPVKMRLTFRRYFEKGAGFLKKKKKLLITIRTTITRFLKR*" /label="spcQ CDS" gene 68106..68741 /gene="spcQ" /locus_tag="BSU_00610" /old_locus_tag="BSU00610" /label="spcQ gene" promotor_-35 68611..68620 /Source="Nicolas_upshift_promotors" /id="U58" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1706 /SigmaFactorBS="tgtgttttccgatccgttttatcgcgaaacaatgttTGAAAC TTCTtcctgtgaaaatGCGTCTAACTTTTAGAcgttattttgaaaaaggtgcaggatt t" /listShort="divIC, yabR, trnSL-Met1, trnSL-Glu1, S36" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 68633..68648 /Source="Nicolas_upshift_promotors" /id="U58" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1706 /SigmaFactorBS="tgtgttttccgatccgttttatcgcgaaacaatgttTGAAAC TTCTtcctgtgaaaatGCGTCTAACTTTTAGAcgttattttgaaaaaggtgcaggatt t" /listShort="divIC, yabR, trnSL-Met1, trnSL-Glu1, S36" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 68635 /Source="Nicolas_upshifts" /id="U58" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1706 /SigmaFactorBS="tgtgttttccgatccgttttatcgcgaaacaatgttTGAAAC TTCTtcctgtgaaaatGCGTCTAACTTTTAGAcgttattttgaaaaaggtgcaggatt t" /listShort="divIC, yabR, trnSL-Met1, trnSL-Glu1, S36" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 68667..68675 /Source="Nicolas_upshift_promotors" /id="U59" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=532 /SigmaFactorBS="tctaacttttagacgttattttgaaaaaggtGCAGGATTTct caaaaagaAGAAGAAACTATTGATAACcataagaacgaccatcacacggtttttgaag a" /listShort="divIC, yabR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 68686..68704 /Source="Nicolas_upshift_promotors" /id="U59" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=532 /SigmaFactorBS="tctaacttttagacgttattttgaaaaaggtGCAGGATTTct caaaaagaAGAAGAAACTATTGATAACcataagaacgaccatcacacggtttttgaag a" /listShort="divIC, yabR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 68696 /Source="Nicolas_upshifts" /id="U59" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=532 /SigmaFactorBS="tctaacttttagacgttattttgaaaaaggtGCAGGATTTct caaaaagaAGAAGAAACTATTGATAACcataagaacgaccatcacacggtttttgaag a" /listShort="divIC, yabR" /GFF_Attribute="listLong" /label="upshifts" CDS 68759..69136 /gene="divIC" /locus_tag="BSU_00620" /old_locus_tag="BSU00620" /function="16.13: Shape" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:10844672, 11283287, 11994149, 12682299, 16936019, 20870765, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10844672, 11283287, 11994149, 12682299, 16936019, 20870765, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="cell-division initiation protein" /protein_id="NP_387943.1" /db_xref="EnsemblGenomes-Gn:BSU00620" /db_xref="EnsemblGenomes-Tr:CAB11838" /db_xref="GOA:P37471" /db_xref="InterPro:IPR007060" /db_xref="SubtiList:BG10125" /db_xref="UniProtKB/Swiss-Prot:P37471" /translation="MNFSRERTITEIQNDYKEQVERQNQLKKRRRKGLYRRLTVFGAL VFLTAIVLASSVWSQTSSLSAKEEKKEQLEKELKSLKTKQTDLKEEISKLKDEDYVTE LARRDLFMSGDGEIIFNVEKKSK*" /label="divIC CDS" gene 68759..69136 /gene="divIC" /locus_tag="BSU_00620" /old_locus_tag="BSU00620" /label="divIC gene" CDS 69217..69603 /gene="yabR" /locus_tag="BSU_00630" /old_locus_tag="BSU00630" /EC_number="2.7.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9862121, 15066026, 16014871, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA degradation protein; polyribonucleotide nucleotidyltransferase or phosphorylase" /protein_id="NP_387944.1" /db_xref="EnsemblGenomes-Gn:BSU00630" /db_xref="EnsemblGenomes-Tr:CAB11839" /db_xref="GOA:P37560" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR022967" /db_xref="SubtiList:BG10126" /db_xref="UniProtKB/Swiss-Prot:P37560" /translation="MSIEVGSKLQGKITGITNFGAFVELPGGSTGLVHISEVADNYVK DINDHLKVGDQVEVKVINVEKDGKIGLSIKKAKDRPQARPRNDFRPKESFEQKMNKFL KDSEDRLSSLKRNTESKRGGRGARRG*" /label="yabR CDS" gene 69217..69603 /gene="yabR" /locus_tag="BSU_00630" /old_locus_tag="BSU00630" /label="yabR gene" downshifts 69597 /Source="Nicolas_upshifts" /id="D29" /incds=0 /nref=247 /ntot=274 /MaxReadThrough="3.67278" /MaxDrop="8.3221" /score="23.2738869" /energy="-12.5" /TU="U58" /idTUdmin="U53" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 69711..69718 /Source="Nicolas_upshift_promotors" /id="U60" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.85914085914086" /psig=1 /xcortree=2412 /SigmaFactorBS="gaaaattacaacattaaagtttctGTTGACGAaagagacaaa cctTTGTATTATATAACTTGTGCttagaagcacaaaacaatatggcggtgtagctcag c" /listShort="trnSL-Met1, trnSL-Glu1, S36, spoIIE, yabS, yabT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 69732..69751 /Source="Nicolas_upshift_promotors" /id="U60" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.85914085914086" /psig=1 /xcortree=2412 /SigmaFactorBS="gaaaattacaacattaaagtttctGTTGACGAaagagacaaa cctTTGTATTATATAACTTGTGCttagaagcacaaaacaatatggcggtgtagctcag c" /listShort="trnSL-Met1, trnSL-Glu1, S36, spoIIE, yabS, yabT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 69747 /Source="Nicolas_upshifts" /id="U60" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.85914085914086" /psig=1 /xcortree=2412 /SigmaFactorBS="gaaaattacaacattaaagtttctGTTGACGAaagagacaaa cctTTGTATTATATAACTTGTGCttagaagcacaaaacaatatggcggtgtagctcag c" /listShort="trnSL-Met1, trnSL-Glu1, S36, spoIIE, yabS, yabT" /GFF_Attribute="listLong" /label="upshifts" tRNA 69772..69848 /gene="trnSL-Met1" /locus_tag="BSU_tRNA_10" /product="tRNA-Met" /inference="profile:tRNAscan:1.23" /note="methionine transfer RNA (CAU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Met1 tRNA" gene 69772..69848 /gene="trnSL-Met1" /locus_tag="BSU_tRNA_10" /label="trnSL-Met1 gene" tRNA 69858..69929 /gene="trnSL-Glu1" /locus_tag="BSU_tRNA_11" /product="tRNA-Glu" /inference="profile:tRNAscan:1.23" /note="glutamate transfer RNA (UUC); Evidence 2a: Functionfrom experimental evidences in other organisms; Producttype n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Glu1 tRNA" gene 69858..69929 /gene="trnSL-Glu1" /locus_tag="BSU_tRNA_11" /label="trnSL-Glu1 gene" downshifts 69928 /Source="Nicolas_upshifts" /id="D30" /incds=0 /nref=2 /ntot=58 /MaxReadThrough="4.83761" /MaxDrop="5.55326" /score="25.2769629" /energy="-10.8" /TU="U58,U60" /idTUdmin="U58" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" S_feature 69973..70084 /Source="Nicolas_S_feature" /locus_tag="new_70382_70493" /HighExp="Cold, G180, C30, G135, G150, Oxctl, Paraq, H2O2, Heat, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S36" misc_feature 70080..70099 /Source="Nicolas_upshift_promotors" /id="U61" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.632367632367632" /psig="0.99000999000999" /xcortree=442 /SigmaFactorBS="cgtcgaagatttctttggtattgttaccttcttttgacaaaa tcctatctgtgcTTTCGCTATAATGACAGGCAacgaatataacaggtgggagatgaga g" /listShort="spoIIE, yabS, yabT, tilS" /listLong="hprT, S38, ftsH" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 70086 /Source="Nicolas_upshifts" /id="U61" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.632367632367632" /psig="0.99000999000999" /xcortree=442 /SigmaFactorBS="cgtcgaagatttctttggtattgttaccttcttttgacaaaa tcctatctgtgcTTTCGCTATAATGACAGGCAacgaatataacaggtgggagatgaga g" /listShort="spoIIE, yabS, yabT, tilS" /listLong="hprT, S38, ftsH" /label="upshifts" CDS 70129..72612 /gene="spoIIE" /locus_tag="BSU_00640" /old_locus_tag="BSU00640" /EC_number="3.1.3.16" /function="16.3: Control" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10747015, 12180929, 15126482, 15866939, 15978076, 28358838" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10747015, 12180929, 15126482, 15866939, 15978076, 28358838; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="SpoIIAA-phosphate serine phosphatase" /protein_id="NP_387945.1" /db_xref="EnsemblGenomes-Gn:BSU00640" /db_xref="EnsemblGenomes-Tr:CAB11840" /db_xref="GOA:P37475" /db_xref="InterPro:IPR001932" /db_xref="InterPro:IPR014221" /db_xref="InterPro:IPR036457" /db_xref="PDB:3T91" /db_xref="PDB:3T9Q" /db_xref="PDB:5UCG" /db_xref="SubtiList:BG10127" /db_xref="UniProtKB/Swiss-Prot:P37475" /translation="MEKAERRVNGPMAGQALEKLQSFFNRGTKLVTHHLHSLFFYKGF IYVVIGFLLGRAFILSEVLPFALPFFGAMLLIRRDKAFYAVLAVLAGALTISPKHSLL ILAALLAFFVFSKVAAFITDDRVKALPIVVFFSMAAARAGFVYAQNGVFTTYDYVMAI VEAGLSFILTLIFLQSLPIFTVKKVKQSLKIEEIICFMILIASVLTGLAGLSYQGMQA EHILARYVVLSFSFIGGASIGCTVGVVTGLILGLANIGNLYQMSLLAFSGLLGGLLKE GKKAGAAIGLIVGSLLISLYGEGSAGLMTTLYESLIAVCLFLLTPQSITRKVARYIPG TVEHLQEQQQYARKIRDVTAQKVDQFSNVFHALSESFATFYQASDEQTDDSEVDLFLS KITEHSCQTCYKKNRCWVQNFDKTYDLMKQVMLETEEKEYASNRRLKKEFQQYCSKSK QVEELIEDELAHHHAHLTLKKKVQDSRRLVAEQLLGVSEVMADFSREIKREREQHFLQ EEQIIEALQHFGIEIQHVEIYSLEQGNIDIEMTIPFSGHGESEKIIAPMLSDILEEQI LVKAEQHSPHPNGYSHVAFGSTKSYRVSTGAAHAAKGGGLVSGDSYSMMELGARKYAA AISDGMGNGARAHFESNETIKLLEKILESGIDEKIAIKTINSILSLRTTDEIYSTLDL SIIDLQDASCKFLKVGSTPSFIKRGDQVMKVQASNLPIGIINEFDVEVVSEQLKAGDL LIMMSDGIFEGPKHVENHDLWMKRKMKGLKTNDPQEIADLLMEEVIRTRSGQIEDDMT VVVVRIDHNTPKWASIPVPAIFQNKQEIS*" /label="spoIIE CDS" gene 70129..72612 /gene="spoIIE" /locus_tag="BSU_00640" /old_locus_tag="BSU00640" /label="spoIIE gene" downshifts 70170 /Source="Nicolas_upshifts" /id="D31" /incds=0 /nref=1 /ntot=20 /MaxReadThrough="5.5737" /MaxDrop="3.93473" /score="25.2769629" /energy="-10.8" /TU="U60,U61" /idTUdmin="U58" /TUdmin=44 /isTUend="FALSE" /label="downshifts" S_feature complement(70781..71390) /Source="Nicolas_S_feature" /locus_tag="new_71190_71799_c" /HighExp="S8, S6, S4, S5, S3, S7, M9-stat, T5.0H, LoTm, Pyr" /AntisenseName="spoIIE" /AntisenseCor="0.685558251745638" /AntisenseRegPval="-38" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S37" downshifts complement(70807) /Source="Nicolas_upshifts" /id="D32" /incds=1 /nref=2 /ntot=11 /MaxReadThrough="2.2425" /MaxDrop="4.29972" /score="-0.425236437" /energy="-13.9" /TU="NA" /idTUdmin="U62" /TUdmin=11 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(71363..71381) /Source="Nicolas_upshift_promotors" /id="U62" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1071 /SigmaFactorBS="cttttttcagccttcggtttgatgcatattctttttcctctg tttcaAGCATAacttgtttcattaagTCATATGTTTTATCAAAGTtctgtacccagca c" /listShort="S37" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(71389) /Source="Nicolas_upshifts" /id="U62" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1071 /SigmaFactorBS="cttttttcagccttcggtttgatgcatattctttttcctctg tttcaAGCATAacttgtttcattaagTCATATGTTTTATCAAAGTtctgtacccagca c" /listShort="S37" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(71397..71402) /Source="Nicolas_upshift_promotors" /id="U62" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1071 /SigmaFactorBS="cttttttcagccttcggtttgatgcatattctttttcctctg tttcaAGCATAacttgtttcattaagTCATATGTTTTATCAAAGTtctgtacccagca c" /listShort="S37" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 71594..71600 /Source="Nicolas_upshift_promotors" /id="U63" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=158 /SigmaFactorBS="ccttgttgctgaacagcttttaggcgtttctgAGGTTATggc cgacttttctcGGGAAATAAAAAGAGAGCGagaacaacactttctgcaggaagagcaa a" /listShort="yabS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 71615..71633 /Source="Nicolas_upshift_promotors" /id="U63" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=158 /SigmaFactorBS="ccttgttgctgaacagcttttaggcgtttctgAGGTTATggc cgacttttctcGGGAAATAAAAAGAGAGCGagaacaacactttctgcaggaagagcaa a" /listShort="yabS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 71622 /Source="Nicolas_upshifts" /id="U63" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=158 /SigmaFactorBS="ccttgttgctgaacagcttttaggcgtttctgAGGTTATggc cgacttttctcGGGAAATAAAAAGAGAGCGagaacaacactttctgcaggaagagcaa a" /listShort="yabS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 72632..72635 /Source="Nicolas_upshift_promotors" /id="U64" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.842157842157842" /psig="0.842157842157842" /xcortree=1198 /SigmaFactorBS="aacaagaaatttcataacgcttccgtataaatcaaaTTTCtt ctggcgaagatgggaATATATGAATCTGAGAATcctcgtattctccaggaggaatgaa t" /listShort="yabS, yabT, tilS, hprT, S38, ftsH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 72653..72670 /Source="Nicolas_upshift_promotors" /id="U64" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.842157842157842" /psig="0.842157842157842" /xcortree=1198 /SigmaFactorBS="aacaagaaatttcataacgcttccgtataaatcaaaTTTCtt ctggcgaagatgggaATATATGAATCTGAGAATcctcgtattctccaggaggaatgaa t" /listShort="yabS, yabT, tilS, hprT, S38, ftsH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 72656 /Source="Nicolas_upshifts" /id="U64" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.842157842157842" /psig="0.842157842157842" /xcortree=1198 /SigmaFactorBS="aacaagaaatttcataacgcttccgtataaatcaaaTTTCtt ctggcgaagatgggaATATATGAATCTGAGAATcctcgtattctccaggaggaatgaa t" /listShort="yabS, yabT, tilS, hprT, S38, ftsH" /GFF_Attribute="listLong" /label="upshifts" CDS 72697..73434 /gene="yabS" /locus_tag="BSU_00650" /old_locus_tag="BSU00650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_387946.1" /db_xref="EnsemblGenomes-Gn:BSU00650" /db_xref="EnsemblGenomes-Tr:CAB11841" /db_xref="InterPro:IPR002035" /db_xref="InterPro:IPR036465" /db_xref="SubtiList:BG10128" /db_xref="UniProtKB/Swiss-Prot:P37561" /translation="MNNGHLNQILLITDGCSNHGEDPLAMAAFAKEQGITVNVIGIME ENQIDPEAMKEVEGIALAGGGVHQVVYASQLSQTVQMVTKKAMTQTLQGVVNQELKQI LGKNVEMEELSPEKRGEVMEVVDELGETVHLQVLVLVDTSASMAPKLPTVKEALIDLS VSLNSRIGNNEFAMCIFPGKKQEVELVLNWTPKLQSLSTLFAKLSTGGITPTGPAIRE ATLQFEKIRSRRGMLADDERRFDEFGM*" /label="yabS CDS" gene 72697..73434 /gene="yabS" /locus_tag="BSU_00650" /old_locus_tag="BSU00650" /label="yabS gene" CDS 73400..74416 /gene="prkT" /locus_tag="BSU_00660" /old_locus_tag="BSU00660" /EC_number="2.7.11.1" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:23634894, 24731262, 25278935" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23634894, 24731262, 25278935; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="serine/threonine-protein kinase" /protein_id="NP_387947.2" /db_xref="EnsemblGenomes-Gn:BSU00660" /db_xref="EnsemblGenomes-Tr:CAB11842" /db_xref="GOA:P37562" /db_xref="InterPro:IPR000719" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR017441" /db_xref="SubtiList:BG10129" /db_xref="UniProtKB/Swiss-Prot:P37562" /translation="MMNDALTSLACSLKPGTTIKGKWNGNTYTLRKQLGKGANGIVYL AETSDGHVALKVSDDSLSITSEVNVLKSFSKAQSVTMGPSFFDTDDAYIPSANTKVSF YAMEYIKGPLLLKYVSDKGAEWIPVLMIQLLSSLSVLHQQGWIFGDLKPDNLIVTGPP ARIRCIDVGGTTKEGRAIKEYTEFYDRGYWGYGTRKAEPSYDLFAVAMIMINSVHKKE FKKTNQPKEQLRSLIEGNPLLQKYKKALFSALNGDYQSADEMKKDMLDAGQKAAQRKQ PIKASPQPATRQRQQKPRQGKITKTRYTPKQKPAKSGGLFETTLIVISVLALYFAYII FFLI*" /label="prkT CDS" gene 73400..74416 /gene="prkT" /locus_tag="BSU_00660" /old_locus_tag="BSU00660" /label="prkT gene" promotor_-35 73948..73954 /Source="Nicolas_upshift_promotors" /id="U65" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=159 /SigmaFactorBS="aaggaaggccgggcgataaaagagtatacggaGTTTTATgac agaggctattggGGGTATGGAACAAGAAAGGcagagccatcctatgatctgttcgcag t" /GFF_Attribute="listShort" /listLong="tilS, hprT, S38, ftsH" /label="promotor_-35" promotor_-10 73970..73988 /Source="Nicolas_upshift_promotors" /id="U65" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=159 /SigmaFactorBS="aaggaaggccgggcgataaaagagtatacggaGTTTTATgac agaggctattggGGGTATGGAACAAGAAAGGcagagccatcctatgatctgttcgcag t" /GFF_Attribute="listShort" /listLong="tilS, hprT, S38, ftsH" /label="promotor_-10" upshifts 73976 /Source="Nicolas_upshifts" /id="U65" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=159 /SigmaFactorBS="aaggaaggccgggcgataaaagagtatacggaGTTTTATgac agaggctattggGGGTATGGAACAAGAAAGGcagagccatcctatgatctgttcgcag t" /GFF_Attribute="listShort" /listLong="tilS, hprT, S38, ftsH" /label="upshifts" promotor_-35 74446..74453 /Source="Nicolas_upshift_promotors" /id="U66" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.723276723276723" /psig=1 /xcortree=1948 /SigmaFactorBS="atggtgcaaactgcagagcctatgcttctTCTTTGCTtggag gggttgaaAGTGTTAGGATATGAATATCtttaaaatacctgctcattgtgaggaggac a" /listShort="tilS, hprT, S38, ftsH, S39, S40, coaX, hslO, yacD" /listLong="cysK, pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-35" promotor_-10 74467..74486 /Source="Nicolas_upshift_promotors" /id="U66" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.723276723276723" /psig=1 /xcortree=1948 /SigmaFactorBS="atggtgcaaactgcagagcctatgcttctTCTTTGCTtggag gggttgaaAGTGTTAGGATATGAATATCtttaaaatacctgctcattgtgaggaggac a" /listShort="tilS, hprT, S38, ftsH, S39, S40, coaX, hslO, yacD" /listLong="cysK, pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-10" upshifts 74477 /Source="Nicolas_upshifts" /id="U66" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.723276723276723" /psig=1 /xcortree=1948 /SigmaFactorBS="atggtgcaaactgcagagcctatgcttctTCTTTGCTtggag gggttgaaAGTGTTAGGATATGAATATCtttaaaatacctgctcattgtgaggaggac a" /listShort="tilS, hprT, S38, ftsH, S39, S40, coaX, hslO, yacD" /listLong="cysK, pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="upshifts" CDS 74520..75938 /gene="tilS" /locus_tag="BSU_00670" /old_locus_tag="BSU00670" /EC_number="6.3.4.19" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14527414, 16039592, 17005971, 22720735, 24001521" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14527414, 16039592, 17005971, 22720735, 24001521; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="tRNA(ile2) lysidine synthetase" /protein_id="NP_387948.1" /db_xref="EnsemblGenomes-Gn:BSU00670" /db_xref="EnsemblGenomes-Tr:CAB11843" /db_xref="GOA:P37563" /db_xref="InterPro:IPR011063" /db_xref="InterPro:IPR012094" /db_xref="InterPro:IPR012795" /db_xref="InterPro:IPR012796" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR015262" /db_xref="InterPro:IPR020825" /db_xref="SubtiList:BG10130" /db_xref="UniProtKB/Swiss-Prot:P37563" /translation="MKSVKDFLNKHNLTLKGATIIVGVSGGPDSMALLHALHTLCGRS ANVIAAHVDHRFRGAESEEDMRFVQAYCKAEQLVCETAQINVTAYAQEKGLNKQAAAR DCRYQFFEEIMSKHQADYLALAHHGDDQVETMLMKLAKGTLGTGLAGMQPVRRFGTGR IIRPFLTITKEEILHYCHENGLSYRTDESNAKDDYTRNRFRKTVLPFLKQESPDVHKR FQKVSEALTEDEQFLQSLTKDEMNKVITSQSNTSVEINSSQLLALPMPLQRRGVQLIL NYLYENVPSSFSAHHIQQFLDWAENGGPSGVLDFPKGLKVVKSYQTCLFTFEQWQCKN VPFEYQISGAADETAVLPNGYLIEARHYADSPEEHGNAVFITSEKKVRFPLTIRTRKA GDRIKLKGMNGSKKVKDIFIDKKLPLQERDNWPIVTDASGEIIWIPGLKKSIFEDLVI PNSDRIVLQYRQHEKCRGQAKS*" /label="tilS CDS" gene 74520..75938 /gene="tilS" /locus_tag="BSU_00670" /old_locus_tag="BSU00670" /label="tilS gene" promotor_-35 75315..75322 /Source="Nicolas_upshift_promotors" /id="U67" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.721278721278721" /psig="0.999000999001" /xcortree=1885 /SigmaFactorBS="aaatcaattcctctcaattgcttgccctcccgatgCCTTTAC AaagaagaggagttcAACTAATATTAAACTATCTTtatgaaaacgttccatcatcctt t" /listShort="hprT, S38, ftsH, S39, S40, coaX, hslO, yacD" /listLong="cysK, pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-35" promotor_-10 75337..75356 /Source="Nicolas_upshift_promotors" /id="U67" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.721278721278721" /psig="0.999000999001" /xcortree=1885 /SigmaFactorBS="aaatcaattcctctcaattgcttgccctcccgatgCCTTTAC AaagaagaggagttcAACTAATATTAAACTATCTTtatgaaaacgttccatcatcctt t" /listShort="hprT, S38, ftsH, S39, S40, coaX, hslO, yacD" /listLong="cysK, pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-10" upshifts 75340 /Source="Nicolas_upshifts" /id="U67" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.721278721278721" /psig="0.999000999001" /xcortree=1885 /SigmaFactorBS="aaatcaattcctctcaattgcttgccctcccgatgCCTTTAC AaagaagaggagttcAACTAATATTAAACTATCTTtatgaaaacgttccatcatcctt t" /listShort="hprT, S38, ftsH, S39, S40, coaX, hslO, yacD" /listLong="cysK, pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="upshifts" downshifts complement(75933) /Source="Nicolas_upshifts" /id="D33" /incds=0 /nref=2 /ntot=142 /MaxReadThrough="2.51342" /MaxDrop="2.96272" /score="12.3455896" /energy="-9.1" /TU="NA" /idTUdmin="U68" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" CDS 75935..76477 /gene="hprT" /locus_tag="BSU_00680" /old_locus_tag="BSU00680" /EC_number="2.4.2.8" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:3110131, 6408059, 24001521" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3110131, 6408059, 24001521; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="hypoxanthine-guanine phosphoribosyltransferase" /protein_id="NP_387949.1" /db_xref="EnsemblGenomes-Gn:BSU00680" /db_xref="EnsemblGenomes-Tr:CAB11844" /db_xref="GOA:P37472" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR005904" /db_xref="InterPro:IPR029057" /db_xref="SubtiList:BG10131" /db_xref="UniProtKB/Swiss-Prot:P37472" /translation="MMKHDIEKVLISEEEIQKKVKELGAELTSEYQDTFPLAIGVLKG ALPFMADLIKHIDTYLEMDFMDVSSYGNSTVSSGEVKIIKDLDTSVEGRDILIIEDII DSGLTLSYLVELFRYRKAKSIKIVTLLDKPSGRKADIKADFVGFEVPDAFVVGYGLDY AERYRNLPYIGVLKPAVYES*" /label="hprT CDS" gene 75935..76477 /gene="hprT" /locus_tag="BSU_00680" /old_locus_tag="BSU00680" /label="hprT gene" upshifts complement(76340) /Source="Nicolas_upshifts" /id="U68" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.988011988011988" /psig="0.002997002997003" /xcortree=41 /SigmaFactorBS="aacccactacaaacgcgtcaggaacttcaaaacCGACaaagt ctgctttgatgtCCGCTtttcttccgctcggtttatccaaaagggtaacaatcttaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(76342..76346) /Source="Nicolas_upshift_promotors" /id="U68" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.988011988011988" /psig="0.002997002997003" /xcortree=41 /SigmaFactorBS="aacccactacaaacgcgtcaggaacttcaaaacCGACaaagt ctgctttgatgtCCGCTtttcttccgctcggtttatccaaaagggtaacaatcttaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(76364..76367) /Source="Nicolas_upshift_promotors" /id="U68" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.988011988011988" /psig="0.002997002997003" /xcortree=41 /SigmaFactorBS="aacccactacaaacgcgtcaggaacttcaaaacCGACaaagt ctgctttgatgtCCGCTtttcttccgctcggtttatccaaaagggtaacaatcttaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 76478..76574 /Source="Nicolas_S_feature" /locus_tag="new_76887_76983" /HighExp="Diami, H2O2, dia5, G135, dia15, G150, Paraq, C90, G180, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigEF" /TUshortPSig="0.999, 1, 0.842" /TUlongSig="SigB, SigA" /TUlongPSig="1, 0.99" /label="S38" CDS 76575..78488 /gene="ftsH" /locus_tag="BSU_00690" /old_locus_tag="BSU00690" /EC_number="3.4.24.-" /function="16.9: Replicate" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9076729, 9084181, 9287010, 9352926, 10851010, 10913836, 12533473, 24001521, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9076729, 9084181, 9287010, 9352926, 10851010, 10913836, 12533473, 24001521, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent cytoplasmic membrane protease" /protein_id="NP_387950.1" /db_xref="EnsemblGenomes-Gn:BSU00690" /db_xref="EnsemblGenomes-Tr:CAB11845" /db_xref="GOA:P37476" /db_xref="InterPro:IPR000642" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR003960" /db_xref="InterPro:IPR005936" /db_xref="InterPro:IPR011546" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR037219" /db_xref="SubtiList:BG10132" /db_xref="UniProtKB/Swiss-Prot:P37476" /translation="MNRVFRNTIFYLLILLVVIGVVSYFQTSNPKTENMSYSTFIKNL DDGKVDSVSVQPVRGVYEVKGQLKNYDKDQYFLTHVPEGKGADQIFNALKKTDVKVEP AQETSGWVTFLTTIIPFVIIFILFFFLLNQAQGGGSRVMNFGKSKAKLYTEEKKRVKF KDVAGADEEKQELVEVVEFLKDPRKFAELGARIPKGVLLVGPPGTGKTLLAKACAGEA GVPFFSISGSDFVEMFVGVGASRVRDLFENAKKNAPCLIFIDEIDAVGRQRGAGLGGG HDEREQTLNQLLVEMDGFSANEGIIIIAATNRADILDPALLRPGRFDRQITVDRPDVI GREAVLKVHARNKPLDETVNLKSIAMRTPGFSGADLENLLNEAALVAARQNKKKIDAR DIDEATDRVIAGPAKKSRVISKKERNIVAYHEGGHTVIGLVLDEADMVHKVTIVPRGQ AGGYAVMLPREDRYFQTKPELLDKIVGLLGGRVAEEIIFGEVSTGAHNDFQRATNIAR RMVTEFGMSEKLGPLQFGQSQGGQVFLGRDFNNEQNYSDQIAYEIDQEIQRIIKECYE RAKQILTENRDKLELIAQTLLKVETLDAEQIKHLIDHGTLPERNFSDDEKNDDVKVNI LTKTEEKKDDTKE*" /label="ftsH CDS" gene 76575..78488 /gene="ftsH" /locus_tag="BSU_00690" /old_locus_tag="BSU00690" /label="ftsH gene" downshifts 78486 /Source="Nicolas_upshifts" /id="D34" /incds=0 /nref=187 /ntot=269 /MaxReadThrough="5.00908" /MaxDrop="8.91482" /score="38.4132386" /energy="-12.9" /TU="U66,U67" /idTUdmin="U64" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(78525..78529) /Source="Nicolas_upshift_promotors" /id="U69" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.955044955044955" /psig="0.000999000999001" /xcortree=66 /SigmaFactorBS="aaatcgataccagaattggatgattgtaaaagccgcagctga gccaatcatttacataaaaaaaCTGCCagcgtcagccggcagtttttttagaaagaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 78531..78616 /Source="Nicolas_S_feature" /locus_tag="new_78940_79025" /HighExp="H2O2, G180, G135, dia15, Paraq, G150, Oxctl, Diami, Cold, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S39" upshifts complement(78533) /Source="Nicolas_upshifts" /id="U69" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.955044955044955" /psig="0.000999000999001" /xcortree=66 /SigmaFactorBS="aaatcgataccagaattggatgattgtaaaagccgcagctga gccaatcatttacataaaaaaaCTGCCagcgtcagccggcagtttttttagaaagaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 78593..78600 /Source="Nicolas_upshift_promotors" /id="U70" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig=1 /xcortree=1864 /SigmaFactorBS="gcggcttttacaatcatccaattctggtatcgattTGTTTAC AaatgagccgctgaTCGTGTATGGTATTGTAGAAtgtttgtaaaaagtaaagtagaga a" /listShort="S40, coaX, hslO, yacD, cysK" /listLong="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-35" promotor_-10 78614..78633 /Source="Nicolas_upshift_promotors" /id="U70" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig=1 /xcortree=1864 /SigmaFactorBS="gcggcttttacaatcatccaattctggtatcgattTGTTTAC AaatgagccgctgaTCGTGTATGGTATTGTAGAAtgtttgtaaaaagtaaagtagaga a" /listShort="S40, coaX, hslO, yacD, cysK" /listLong="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-10" S_feature 78618..78682 /Source="Nicolas_S_feature" /locus_tag="new_79027_79091" /HighExp="dia5, H2O2, dia15, Paraq, Diami, G180, LBGexp, Oxctl, G135, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S40" upshifts 78618 /Source="Nicolas_upshifts" /id="U70" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig=1 /xcortree=1864 /SigmaFactorBS="gcggcttttacaatcatccaattctggtatcgattTGTTTAC AaatgagccgctgaTCGTGTATGGTATTGTAGAAtgtttgtaaaaagtaaagtagaga a" /listShort="S40, coaX, hslO, yacD, cysK" /listLong="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="upshifts" CDS 78683..79459 /gene="coaX" /locus_tag="BSU_00700" /old_locus_tag="BSU00700" /EC_number="2.7.1.33" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15795230, 16905099, 24784177" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15795230, 16905099, 24784177; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pantothenate kinase type III" /protein_id="NP_387951.2" /db_xref="EnsemblGenomes-Gn:BSU00700" /db_xref="EnsemblGenomes-Tr:CAB11846" /db_xref="GOA:P37564" /db_xref="InterPro:IPR004619" /db_xref="SubtiList:BG10133" /db_xref="UniProtKB/Swiss-Prot:P37564" /translation="MLLVIDVGNTNTVLGVYHDGKLEYHWRIETSRHKTEDEFGMILR SLFDHSGLMFEQIDGIIISSVVPPIMFALERMCTKYFHIEPQIVGPGMKTGLNIKYDN PKEVGADRIVNAVAAIHLYGNPLIVVDFGTATTYCYIDENKQYMGGAIAPGITISTEA LYSRAAKLPRIEITRPDNIIGKNTVSAMQSGILFGYVGQVEGIVKRMKWQAKQEPKVI ATGGLAPLIANESDCIDIVDPFLTLKGLELIYERNRVGSV*" /label="coaX CDS" gene 78683..79459 /gene="coaX" /locus_tag="BSU_00700" /old_locus_tag="BSU00700" /label="coaX gene" CDS 79471..80346 /gene="hslO" /locus_tag="BSU_00710" /old_locus_tag="BSU00710" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11323724, 15023991; Product type f: factor" /codon_start=1 /transl_table=11 /product="disulfide bond chaperone (heat shock protein HSP33)" /protein_id="NP_387952.1" /db_xref="EnsemblGenomes-Gn:BSU00710" /db_xref="EnsemblGenomes-Tr:CAB11847" /db_xref="GOA:P37565" /db_xref="InterPro:IPR000397" /db_xref="InterPro:IPR016153" /db_xref="InterPro:IPR016154" /db_xref="PDB:1VZY" /db_xref="SubtiList:BG10134" /db_xref="UniProtKB/Swiss-Prot:P37565" /translation="MDYLVKALAYDGKVRAYAARTTDMVNEGQRRHGTWPTASAALGR TMTASLMLGAMLKGDDKLTVKIEGGGPIGAIVADANAKGEVRAYVSNPQVHFDLNEQG KLDVRRAVGTNGTLSVVKDLGLREFFTGQVEIVSGELGDDFTYYLVSSEQVPSSVGVG VLVNPDNTILAAGGFIIQLMPGTDDETITKIEQRLSQVEPISKLIQKGLTPEEILEEV LGEKPEILETMPVRFHCPCSKERFETAILGLGKKEIQDMIEEDGQAEAVCHFCNEKYL FTKEELEGLRDQTTR*" /label="hslO CDS" gene 79471..80346 /gene="hslO" /locus_tag="BSU_00710" /old_locus_tag="BSU00710" /label="hslO gene" CDS 80393..81286 /gene="yacD" /locus_tag="BSU_00720" /old_locus_tag="BSU00720" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15187182, 15856219; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative protein chaperone accessory lipoproteinfactor" /protein_id="NP_387953.1" /db_xref="EnsemblGenomes-Gn:BSU00720" /db_xref="EnsemblGenomes-Tr:CAB11848" /db_xref="GOA:P37566" /db_xref="InterPro:IPR000297" /db_xref="InterPro:IPR023058" /db_xref="InterPro:IPR027304" /db_xref="SubtiList:BG10135" /db_xref="UniProtKB/Swiss-Prot:P37566" /translation="MKSRTIWTIILGALLVCCIAVAYTLTKSQAGASSSGESIATIGG KSVTREEWLKEMEDQYGKSTLEDMINVRVVEQLAKKNKLKISKSEVDREFLLIKAVNN SFYEDEHTTEKEWKDQIRYNILLEDLLTRDIDISNKELESFYNKNKELYQFDDSYRIR HIVVKDEEEAREVLKELKGGSSFEAVAAERSTDRYTSPYGGDLGFVTEASDNIPSAYI EEAKTLKEDEWSQEPIKVSNGYAIIQLKEKLKARTFSFDEVKDQIRRQIAMDQLGDKA TVKTLWKEADVSWFYGEKSTK*" /label="yacD CDS" gene 80393..81286 /gene="yacD" /locus_tag="BSU_00720" /old_locus_tag="BSU00720" /label="yacD gene" promotor_-35 81016..81021 /Source="Nicolas_upshift_promotors" /id="U71" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1220 /SigmaFactorBS="catcaccatacggcggagatttaggttttgtcacagaGGCAT CagacaacattccatcaGCATACATTGAAGAGGCGAaaacactcaaagaggatgaatg g" /listShort="cysK" /listLong="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="promotor_-35" promotor_-10 81038..81056 /Source="Nicolas_upshift_promotors" /id="U71" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1220 /SigmaFactorBS="catcaccatacggcggagatttaggttttgtcacagaGGCAT CagacaacattccatcaGCATACATTGAAGAGGCGAaaacactcaaagaggatgaatg g" /listShort="cysK" /listLong="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="promotor_-10" upshifts 81039 /Source="Nicolas_upshifts" /id="U71" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1220 /SigmaFactorBS="catcaccatacggcggagatttaggttttgtcacagaGGCAT CagacaacattccatcaGCATACATTGAAGAGGCGAaaacactcaaagaggatgaatg g" /listShort="cysK" /listLong="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="upshifts" promotor_-35 81285..81292 /Source="Nicolas_upshift_promotors" /id="U72" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.844155844155844" /psig=1 /xcortree=1740 /SigmaFactorBS="tcttggttttatggggaaaaaagtactaagtGATTGACAaaa aattttgaaatTGATAGATTATATACATAATaccaatacaaatagtcggaaattgagg t" /listShort="cysK, pabB, pabA, pabC, sul" /listLong="folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-35" promotor_-10 81307..81326 /Source="Nicolas_upshift_promotors" /id="U72" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.844155844155844" /psig=1 /xcortree=1740 /SigmaFactorBS="tcttggttttatggggaaaaaagtactaagtGATTGACAaaa aattttgaaatTGATAGATTATATACATAATaccaatacaaatagtcggaaattgagg t" /listShort="cysK, pabB, pabA, pabC, sul" /listLong="folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-10" upshifts 81314 /Source="Nicolas_upshifts" /id="U72" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.844155844155844" /psig=1 /xcortree=1740 /SigmaFactorBS="tcttggttttatggggaaaaaagtactaagtGATTGACAaaa aattttgaaatTGATAGATTATATACATAATaccaatacaaatagtcggaaattgagg t" /listShort="cysK, pabB, pabA, pabC, sul" /listLong="folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="upshifts" CDS 81362..82288 /gene="cysK" /locus_tag="BSU_00730" /old_locus_tag="BSU00730" /EC_number="2.5.1.47" /EC_number="4.4.1.1" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11390694, 15760717, 16267287, 16513748, 17056751, 18974048" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11390694, 15760717, 16267287, 16513748, 17056751, 18974048; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cysteine synthase" /protein_id="NP_387954.1" /db_xref="EnsemblGenomes-Gn:BSU00730" /db_xref="EnsemblGenomes-Tr:CAB11849" /db_xref="GOA:P37887" /db_xref="InterPro:IPR001216" /db_xref="InterPro:IPR001926" /db_xref="InterPro:IPR005856" /db_xref="InterPro:IPR005859" /db_xref="InterPro:IPR036052" /db_xref="SubtiList:BG10136" /db_xref="UniProtKB/Swiss-Prot:P37887" /translation="MVRVANSITELIGNTPIVKLNRLADENSADVYLKLEYMNPGSSV KDRIGLAMIEAAEKEGKLKAGNTIIEPTSGNTGIGLAMVAAAKGLKAILVMPDTMSME RRNLLRAYGAELVLTPGAEGMKGAIKKAEELAEKHGYFVPQQFNNPSNPEIHRQTTGK EIVEQFGDDQLDAFVAGIGTGGTITGAGEVLKEAYPSIKIYAVEPSDSPVLSGGKPGP HKIQGIGAGFVPDILNTEVYDEIFPVKNEEAFEYARRAAREEGILGGISSGAAIYAAL QVAKKLGKGKKVLAIIPSNGERYLSTPLYQFD*" /label="cysK CDS" gene 81362..82288 /gene="cysK" /locus_tag="BSU_00730" /old_locus_tag="BSU00730" /label="cysK gene" downshifts 82281 /Source="Nicolas_upshifts" /id="D35" /incds=0 /nref=156 /ntot=259 /MaxReadThrough="5.90023" /MaxDrop="5.38596" /score="41.7897705" /energy="-11.4" /TU="U72" /idTUdmin="U70" /TUdmin=10 /isTUend="TRUE" /label="downshifts" promotor_-35 82335..82343 /Source="Nicolas_upshift_promotors" /id="U73" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.787212787212787" /psig="0.787212787212787" /xcortree=1723 /SigmaFactorBS="aactcccggttcgccgggagtttttttatatttcgtGCATCA AATatgccatgtctgcGACGAATGTtattcttggaagagaaattcacttttttcacta a" /listShort="pabB" /listLong="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="promotor_-35" promotor_-10 82357..82365 /Source="Nicolas_upshift_promotors" /id="U73" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.787212787212787" /psig="0.787212787212787" /xcortree=1723 /SigmaFactorBS="aactcccggttcgccgggagtttttttatatttcgtGCATCA AATatgccatgtctgcGACGAATGTtattcttggaagagaaattcacttttttcacta a" /listShort="pabB" /listLong="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="promotor_-10" upshifts 82359 /Source="Nicolas_upshifts" /id="U73" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.787212787212787" /psig="0.787212787212787" /xcortree=1723 /SigmaFactorBS="aactcccggttcgccgggagtttttttatatttcgtGCATCA AATatgccatgtctgcGACGAATGTtattcttggaagagaaattcacttttttcacta a" /listShort="pabB" /listLong="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="upshifts" promotor_-35 82387..82390 /Source="Nicolas_upshift_promotors" /id="U74" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.7992007992008" /psig="0.998001998001998" /xcortree=2267 /SigmaFactorBS="gcgacgaatgttattcttggaagagaaattcaCTTTtttcac taacaacaTTGCTTTACAATTAAAAACAagtaaaaaagaaaatagaggaatgatacaa a" /listShort="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /listLong="S43, rrnJ-16S" /label="promotor_-35" promotor_-10 82405..82424 /Source="Nicolas_upshift_promotors" /id="U74" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.7992007992008" /psig="0.998001998001998" /xcortree=2267 /SigmaFactorBS="gcgacgaatgttattcttggaagagaaattcaCTTTtttcac taacaacaTTGCTTTACAATTAAAAACAagtaaaaaagaaaatagaggaatgatacaa a" /listShort="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /listLong="S43, rrnJ-16S" /label="promotor_-10" upshifts 82415 /Source="Nicolas_upshifts" /id="U74" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.7992007992008" /psig="0.998001998001998" /xcortree=2267 /SigmaFactorBS="gcgacgaatgttattcttggaagagaaattcaCTTTtttcac taacaacaTTGCTTTACAATTAAAAACAagtaaaaaagaaaatagaggaatgatacaa a" /listShort="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /listLong="S43, rrnJ-16S" /label="upshifts" CDS 82455..83867 /gene="pabB" /locus_tag="BSU_00740" /old_locus_tag="BSU00740" /EC_number="2.6.1.85" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2123867, 9084182, 16605270, 17114263, 25288929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-amino-4-deoxychorismate synthase (para-aminobenzoate synthase)" /protein_id="NP_387955.1" /db_xref="EnsemblGenomes-Gn:BSU00740" /db_xref="EnsemblGenomes-Tr:CAB11850" /db_xref="GOA:P28820" /db_xref="InterPro:IPR005801" /db_xref="InterPro:IPR006805" /db_xref="InterPro:IPR015890" /db_xref="InterPro:IPR019999" /db_xref="SubtiList:BG10137" /db_xref="UniProtKB/Swiss-Prot:P28820" /translation="MAQRRPAGKKIPFQKDSFLQQFEKLAQSRKHHVLLESARGGRYS IAGLDPIATVKGKDGITTIKHGDEMLFKEGDPLRAFHSWFKTLETETNHEFPDFQGGA IGFLSYDYARYIENFKMLSLDDLETPDIYFLVFDDIAVYDHQEESLWLITHVNGSDQE TADVKLSELEQMWLTELPAVTSREMKPETAGSFAAPFTEDGFSQAVEKIKQYIASGDV FQVNLSIRQSQSLSVHPYQIYKTLREVNPSPYMAYLETPDFQIICGSPELLVSKKGKL LETRPIAGTRSRGKTNEEDEALANELIHNEKERAEHVMLVDLERNDLGRVSRYGSVRV NEFMAIEKYSHVMHIVSNVQGELQDGYDAVDIIHAVFPGGTITGAPKVRTMEIIEELE PTRRGLYTGSIGWFGYNHDLQFNIVIRTIYATGGQAFMQSGAGVVIDSVPKHEYKESF KKAFAMQRALELSEEETKIR*" /label="pabB CDS" gene 82455..83867 /gene="pabB" /locus_tag="BSU_00740" /old_locus_tag="BSU00740" /label="pabB gene" promotor_-35 83257..83259 /Source="Nicolas_upshift_promotors" /id="U75" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.416583416583417" /psig="0.621378621378621" /xcortree=608 /SigmaFactorBS="cctgatttccaaatcatttgcggatcgcctgaacTGCttgtc agcaaaaagggcAAGCTATTAGAGACGAGACcgattgcgggcacccgttccagaggga a" /GFF_Attribute="listShort" /listLong="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="promotor_-35" promotor_-10 83277..83295 /Source="Nicolas_upshift_promotors" /id="U75" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.416583416583417" /psig="0.621378621378621" /xcortree=608 /SigmaFactorBS="cctgatttccaaatcatttgcggatcgcctgaacTGCttgtc agcaaaaagggcAAGCTATTAGAGACGAGACcgattgcgggcacccgttccagaggga a" /GFF_Attribute="listShort" /listLong="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="promotor_-10" upshifts 83283 /Source="Nicolas_upshifts" /id="U75" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.416583416583417" /psig="0.621378621378621" /xcortree=608 /SigmaFactorBS="cctgatttccaaatcatttgcggatcgcctgaacTGCttgtc agcaaaaagggcAAGCTATTAGAGACGAGACcgattgcgggcacccgttccagaggga a" /GFF_Attribute="listShort" /listLong="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="upshifts" promotor_-35 83624..83631 /Source="Nicolas_upshift_promotors" /id="U76" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.57942057942058" /psig="0.998001998001998" /xcortree=2212 /SigmaFactorBS="agtaagaacgatggaaattatagaagaACTTGAGCcgacacg ccgagGGCTTTATACTGGATCTATAggatggtttggatataatcacgatctgcagttt a" /listShort="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /listLong="S43, rrnJ-16S" /label="promotor_-35" promotor_-10 83644..83663 /Source="Nicolas_upshift_promotors" /id="U76" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.57942057942058" /psig="0.998001998001998" /xcortree=2212 /SigmaFactorBS="agtaagaacgatggaaattatagaagaACTTGAGCcgacacg ccgagGGCTTTATACTGGATCTATAggatggtttggatataatcacgatctgcagttt a" /listShort="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /listLong="S43, rrnJ-16S" /label="promotor_-10" upshifts 83657 /Source="Nicolas_upshifts" /id="U76" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.57942057942058" /psig="0.998001998001998" /xcortree=2212 /SigmaFactorBS="agtaagaacgatggaaattatagaagaACTTGAGCcgacacg ccgagGGCTTTATACTGGATCTATAggatggtttggatataatcacgatctgcagttt a" /listShort="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /listLong="S43, rrnJ-16S" /label="upshifts" CDS 83881..84465 /gene="pabA" /locus_tag="BSU_00750" /old_locus_tag="BSU00750" /EC_number="2.6.1.85" /EC_number="4.1.3.27" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9098056, 16605270, 17114263, 24847778; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-amino-4-deoxychorismate synthase; anthranilatesynthase (subunit II)" /protein_id="NP_387956.1" /db_xref="EnsemblGenomes-Gn:BSU00750" /db_xref="EnsemblGenomes-Tr:CAB11851" /db_xref="GOA:P28819" /db_xref="InterPro:IPR006221" /db_xref="InterPro:IPR017926" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG10138" /db_xref="UniProtKB/Swiss-Prot:P28819" /translation="MILMIDNYDSFTYNLVQYLGELGEELVVKRNDSITIDEIEELSP DFLMISPGPCSPDEAGISLEAIKHFAGKIPIFGVCLGHQSIAQVFGGDVVRAERLMHG KTSDIEHDGKTIFEGLKNPLVATRYHSLIVKPETLPSCFTVTAQTKEGEIMAIRHNDL PIEGVQFHPESIMTSFGKEMLRNFIETYRKEVIA*" /label="pabA CDS" gene 83881..84465 /gene="pabA" /locus_tag="BSU_00750" /old_locus_tag="BSU00750" /label="pabA gene" CDS 84465..85346 /gene="pabC" /locus_tag="BSU_00760" /old_locus_tag="BSU00760" /EC_number="4.1.3.38" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10876155, 1644759, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-amino-4-deoxychorismate pyruvate-lyase" /protein_id="NP_387957.1" /db_xref="EnsemblGenomes-Gn:BSU00760" /db_xref="EnsemblGenomes-Tr:CAB11852" /db_xref="GOA:P28821" /db_xref="InterPro:IPR001544" /db_xref="InterPro:IPR017824" /db_xref="InterPro:IPR018300" /db_xref="InterPro:IPR036038" /db_xref="SubtiList:BG10139" /db_xref="UniProtKB/Swiss-Prot:P28821" /translation="MIYVNGRYMEEKDAVLSPFDHGFLYGIGVFETFRLYEGCPFLLD WHIERLERALKDLQIEYTVSKHEILEMLDKLLKLNDIKDGNARVRLNISAGISDKGFV AQTYDKPTVLCFVNQLKPESLPLQKEGKVLSIRRNTPEGSFRLKSHHYLNNMYAKREI GNDPRVEGIFLTEDGAVAEGIISNVFWRKGRCIYTPSLDTGILDGVTRRFIIENAKDI GLELKTGRYELEALLTADEAWMTNSVLEIIPFTKIEEVNYGSQSGEATSALQLLYKKE IKNMIHEKGGRAWRSTQ*" /label="pabC CDS" gene 84465..85346 /gene="pabC" /locus_tag="BSU_00760" /old_locus_tag="BSU00760" /label="pabC gene" CDS 85328..86185 /gene="folP" /locus_tag="BSU_00770" /old_locus_tag="BSU00770" /EC_number="2.5.1.15" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2123867, 11007651; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydropteroate synthase" /protein_id="NP_387958.1" /db_xref="EnsemblGenomes-Gn:BSU00770" /db_xref="EnsemblGenomes-Tr:CAB11853" /db_xref="GOA:P28822" /db_xref="InterPro:IPR000489" /db_xref="InterPro:IPR006390" /db_xref="InterPro:IPR011005" /db_xref="SubtiList:BG10140" /db_xref="UniProtKB/Swiss-Prot:P28822" /translation="MAQHTIDQTQVIHTKPSALSYKEKTLVMGILNVTPDSFSDGGKY DSLDKALLHAKEMIDDGAHIIDIGGESTRPGAECVSEDEEMSRVIPVIERITKELGVP ISVDTYKASVADEAVKAGASIINDIWGAKHDPKMASVAAEHNVPIVLMHNRPERNYND LLPDMLSDLMESVKIAVEAGVDEKNIILDPGIGFAKTYHDNLAVMNKLEIFSGLGYPV LLATSRKRFIGRVLDLPPEERAEGTGATVCLGIQKGCDIVRVHDVKQIARMAKMMDAM LNKGGVHHG*" /label="folP CDS" gene 85328..86185 /gene="folP" /locus_tag="BSU_00770" /old_locus_tag="BSU00770" /label="folP gene" CDS 86178..86540 /gene="folB" /locus_tag="BSU_00780" /old_locus_tag="BSU00780" /EC_number="4.1.2.25" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16188473, 17176045, 17388809; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydroneopterin aldolase" /protein_id="NP_387959.1" /db_xref="EnsemblGenomes-Gn:BSU00780" /db_xref="EnsemblGenomes-Tr:CAB11854" /db_xref="GOA:P28823" /db_xref="InterPro:IPR006156" /db_xref="InterPro:IPR006157" /db_xref="SubtiList:BG10141" /db_xref="UniProtKB/Swiss-Prot:P28823" /translation="MDKVYVEGMEFYGYHGVFTEENKLGQRFKVDLTAELDLSKAGQT DDLEQTINYAELYHVCKDIVEGEPVKLVETLAERIAGTVLGKFQPVQQCTVKVIKPDP PIPGHYKSVAIEITRKKS*" /label="folB CDS" gene 86178..86540 /gene="folB" /locus_tag="BSU_00780" /old_locus_tag="BSU00780" /label="folB gene" CDS 86537..87040 /gene="folK" /locus_tag="BSU_00790" /old_locus_tag="BSU00790" /EC_number="2.7.6.3" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17029412; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase" /protein_id="NP_387960.1" /db_xref="EnsemblGenomes-Gn:BSU00790" /db_xref="EnsemblGenomes-Tr:CAB11855" /db_xref="GOA:P29252" /db_xref="InterPro:IPR000550" /db_xref="InterPro:IPR035907" /db_xref="SubtiList:BG10142" /db_xref="UniProtKB/Swiss-Prot:P29252" /translation="MNNIAYIALGSNIGDRETYLRQAVALLHQHAAVTVTKVSSIYET DPVGYEDQAQFLNMAVEIKTSLNPFELLELTQQIENELGRTREVRWGPRTADLDILLF NRENIETEQLIVPHPRMYERLFVLAPLAEICQQVEKEATSAETDQEGVRVWKQKSGVD EFVHSES*" /label="folK CDS" gene 86537..87040 /gene="folK" /locus_tag="BSU_00790" /old_locus_tag="BSU00790" /label="folK gene" CDS 86992..87201 /gene="yazB" /locus_tag="BSU_00800" /old_locus_tag="BSU00800" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_387961.1" /db_xref="EnsemblGenomes-Gn:BSU00800" /db_xref="EnsemblGenomes-Tr:CAB11856" /db_xref="GOA:O31417" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="SubtiList:BG12701" /db_xref="UniProtKB/Swiss-Prot:O31417" /translation="MEAEIWGRRIRAFRKLKGYTQEGFAKALGISVSILGEIERGNRL PSAAIIQDAADVLNISADELAPPEK*" /label="yazB CDS" gene 86992..87201 /gene="yazB" /locus_tag="BSU_00800" /old_locus_tag="BSU00800" /label="yazB gene" CDS 87225..88226 /gene="dusB" /locus_tag="BSU_00810" /old_locus_tag="BSU00810" /EC_number="1.-.-.-" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11983710, 15698474, 26112661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA-dihydrouridine synthase B" /protein_id="NP_387962.1" /db_xref="EnsemblGenomes-Gn:BSU00810" /db_xref="EnsemblGenomes-Tr:CAB11857" /db_xref="GOA:P37567" /db_xref="InterPro:IPR001269" /db_xref="InterPro:IPR004652" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR018517" /db_xref="InterPro:IPR024036" /db_xref="InterPro:IPR035587" /db_xref="SubtiList:BG10143" /db_xref="UniProtKB/Swiss-Prot:P37567" /translation="MFKIGDIQLKNRVVLAPMAGVCNSAFRLTVKEFGAGLVCAEMVS DKAILYNNARTMGMLYIDEREKPLSLQIFGGKKETLVEAAKFVDQNTTADIIDINMGC PVPKITKCDAGAKWLLDPDKIYEMVSAVVDAVNKPVTVKMRMGWDEDHIFAVKNAQAV ERAGGKAVALHGRTRVQMYEGTANWDIIKEVKQSVSIPVIGNGDVKTPQDAKRMLDET GVDGVMIGRAALGNPWMIYRTVQYLETGKLKEEPQVREKMAVCKLHLDRLIDLKGENV AVREMRKHAAWYLKGVKGNANVRNEINHCETREEFVQLLDAFTVEVEAKELQNAKVG* " /label="dusB CDS" gene 87225..88226 /gene="dusB" /locus_tag="BSU_00810" /old_locus_tag="BSU00810" /label="dusB gene" S_feature complement(87641..89157) /Source="Nicolas_S_feature" /locus_tag="new_88050_89566_c" /HighExp="LoTm, C30, S6, S8, S5, S7, S3, S4, C90, G135" /AntisenseName="dusB" /AntisenseCor="-0.60218706634778196" /AntisenseRegPval="-27.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S41" S_feature 88227..88317 /Source="Nicolas_S_feature" /locus_tag="new_88636_88726" /HighExp="H2O2, G180, G150, Paraq, G135, Oxctl, Diami, C30, LBGexp, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 0.998" /TUlongSig="SigA, SigI, SigA, SigEF, SigA, SigA, SigA" /TUlongPSig="0.621, 0.787, 1, 0.995, 1, 0.999, 1" /label="S42" CDS 88318..89817 /gene="lysS" /locus_tag="BSU_00820" /old_locus_tag="BSU00820" /EC_number="6.1.1.6" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14623972, 20649968" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14623972, 20649968; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="lysyl-tRNA synthetase" /protein_id="NP_387963.1" /db_xref="EnsemblGenomes-Gn:BSU00820" /db_xref="EnsemblGenomes-Tr:CAB11858" /db_xref="GOA:P37477" /db_xref="InterPro:IPR002313" /db_xref="InterPro:IPR004364" /db_xref="InterPro:IPR004365" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR018149" /db_xref="InterPro:IPR034762" /db_xref="SubtiList:BG10144" /db_xref="UniProtKB/Swiss-Prot:P37477" /translation="MSQEEHNHEELNDQLQVRRDKMNQLRDNGIDPFGARFERTHQSQ EVISAYQDLTKEELEEKAIEVTIAGRMMTKRGKGKAGFAHLQDLEGQIQIYVRKDSVG DDQYEIFKSSDLGDLIGVTGKVFKTNVGELSVKATSFELLTKALRPLPDKYHGLKDVE QRYRQRYLDLIVNPDSKHTFITRSKIIQAMRRYLDDHGYLEVETPTMHSIPGGASARP FITHHNALDIPLYMRIAIELHLKRLIVGGLEKVYEIGRVFRNEGVSTRHNPEFTMIEL YEAYADYKDIMSLTENLVAHIAQEVLGTTTIQYGEEQIDLKPEWKRIHMVDAVKEATG VDFWEEVTVEQAREYAKEHEVEIKDSMTVGHIINEFFEQKIEETLIQPTFIYGHPVEI SPLAKKNPEDPRFTDRFELFIVGREHANAFTELNDPIDQRERFEAQLKEREAGNDEAH LMDEDFVEALEYGMPPTGGLGIGIDRLVMLLTNAPSIRDVLLFPQMRQR*" /label="lysS CDS" gene 88318..89817 /gene="lysS" /locus_tag="BSU_00820" /old_locus_tag="BSU00820" /label="lysS gene" promotor_-10 complement(89141..89159) /Source="Nicolas_upshift_promotors" /id="U77" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1081 /SigmaFactorBS="ttcttgggcgatatgagcgacaaggttttcagttaagCTCAT GatatctttatagtccGCATATGCTTCATATAACTcaatcattgtaaattcagggtta t" /listShort="S41" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(89157) /Source="Nicolas_upshifts" /id="U77" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1081 /SigmaFactorBS="ttcttgggcgatatgagcgacaaggttttcagttaagCTCAT GatatctttatagtccGCATATGCTTCATATAACTcaatcattgtaaattcagggtta t" /listShort="S41" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(89175..89180) /Source="Nicolas_upshift_promotors" /id="U77" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1081 /SigmaFactorBS="ttcttgggcgatatgagcgacaaggttttcagttaagCTCAT GatatctttatagtccGCATATGCTTCATATAACTcaatcattgtaaattcagggtta t" /listShort="S41" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 89798 /Source="Nicolas_upshifts" /id="D36" /incds=0 /nref=104 /ntot=219 /MaxReadThrough="4.49559" /MaxDrop="4.89484" /score="4.33485487" /energy="-18.1" /TU="U76" /idTUdmin="U74" /TUdmin=3 /isTUend="TRUE" /label="downshifts" promotor_-35 89893..89900 /Source="Nicolas_upshift_promotors" /id="U78" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2623 /SigmaFactorBS="gatgccgctctttttaaatcccttagtatttcttcaaaaaaa ctATTGCACTattatttactaggTGGTATATTATTATTCGTTGccgctaaacaaggcg a" /listShort="S43, rrnJ-16S, rrnJ-23S, rrnJ-5S, trnJ-Val, trnJ-Thr, trnJ-Lys, trnJ-Leu1, trnJ-Gly, trnJ-Leu2, trnJ-Arg, trnJ-Pro" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 89909..90126 /Source="Nicolas_S_feature" /locus_tag="new_90318_90535" /HighExp="LBGstat, H2O2, Oxctl, Diami, dia15, Paraq, MG 25, Heat, MG 15, UNK1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA, SigA, SigA, SigA, SigA" /TUlongPSig="0.998, 0.998, 1, 1, 0.999, 1" /label="S43" upshifts 89909 /Source="Nicolas_upshifts" /id="U78" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2623 /SigmaFactorBS="gatgccgctctttttaaatcccttagtatttcttcaaaaaaa ctATTGCACTattatttactaggTGGTATATTATTATTCGTTGccgctaaacaaggcg a" /listShort="S43, rrnJ-16S, rrnJ-23S, rrnJ-5S, trnJ-Val, trnJ-Thr, trnJ-Lys, trnJ-Leu1, trnJ-Gly, trnJ-Leu2, trnJ-Arg, trnJ-Pro" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 89914..89933 /Source="Nicolas_upshift_promotors" /id="U78" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2623 /SigmaFactorBS="gatgccgctctttttaaatcccttagtatttcttcaaaaaaa ctATTGCACTattatttactaggTGGTATATTATTATTCGTTGccgctaaacaaggcg a" /listShort="S43, rrnJ-16S, rrnJ-23S, rrnJ-5S, trnJ-Val, trnJ-Thr, trnJ-Lys, trnJ-Leu1, trnJ-Gly, trnJ-Leu2, trnJ-Arg, trnJ-Pro" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(89959) /Source="Nicolas_upshifts" /id="D37" /incds=0 /nref=3 /ntot=51 /MaxReadThrough="3.16217" /MaxDrop="5.0092" /score="18.6635354" /energy="-16.9" /TU="NA" /idTUdmin="U77" /TUdmin="-2288" /isTUend="FALSE" /label="downshifts" rRNA 90127..91680 /gene="rrnJ-16S" /locus_tag="BSU_rRNA_6" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnJ-16S rRNA" gene 90127..91680 /gene="rrnJ-16S" /locus_tag="BSU_rRNA_6" /label="rrnJ-16S gene" rRNA 91845..94772 /gene="rrnJ-23S" /locus_tag="BSU_rRNA_7" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnJ-23S rRNA" gene 91845..94772 /gene="rrnJ-23S" /locus_tag="BSU_rRNA_7" /label="rrnJ-23S gene" rRNA 94828..94945 /gene="rrnJ-5S" /locus_tag="BSU_rRNA_8" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnJ-5S rRNA" gene 94828..94945 /gene="rrnJ-5S" /locus_tag="BSU_rRNA_8" /label="rrnJ-5S gene" tRNA 94966..95041 /gene="trnJ-Val" /locus_tag="BSU_tRNA_12" /product="tRNA-Val" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Val(UAC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnJ-Val tRNA" gene 94966..95041 /gene="trnJ-Val" /locus_tag="BSU_tRNA_12" /label="trnJ-Val gene" tRNA 95046..95121 /gene="trnJ-Thr" /locus_tag="BSU_tRNA_13" /product="tRNA-Thr" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Thr(UGU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnJ-Thr tRNA" gene 95046..95121 /gene="trnJ-Thr" /locus_tag="BSU_tRNA_13" /label="trnJ-Thr gene" tRNA 95158..95233 /gene="trnJ-Lys" /locus_tag="BSU_tRNA_14" /product="tRNA-Lys" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Lys(UUU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnJ-Lys tRNA" gene 95158..95233 /gene="trnJ-Lys" /locus_tag="BSU_tRNA_14" /label="trnJ-Lys gene" tRNA 95240..95322 /gene="trnJ-Leu1" /locus_tag="BSU_tRNA_15" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Leu(UAG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnJ-Leu1 tRNA" gene 95240..95322 /gene="trnJ-Leu1" /locus_tag="BSU_tRNA_15" /label="trnJ-Leu1 gene" tRNA 95363..95437 /gene="trnJ-Gly" /locus_tag="BSU_tRNA_16" /product="tRNA-Gly" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gly(GCC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnJ-Gly tRNA" gene 95363..95437 /gene="trnJ-Gly" /locus_tag="BSU_tRNA_16" /label="trnJ-Gly gene" tRNA 95452..95537 /gene="trnJ-Leu2" /locus_tag="BSU_tRNA_17" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Leu(UAA); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnJ-Leu2 tRNA" gene 95452..95537 /gene="trnJ-Leu2" /locus_tag="BSU_tRNA_17" /label="trnJ-Leu2 gene" tRNA 95547..95623 /gene="trnJ-Arg" /locus_tag="BSU_tRNA_18" /product="tRNA-Arg" /inference="profile:tRNAscan:1.23" /note="arginine transfer RNA(ACG); Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 27749819; Product type n : RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnJ-Arg tRNA" gene 95547..95623 /gene="trnJ-Arg" /locus_tag="BSU_tRNA_18" /label="trnJ-Arg gene" tRNA 95651..95727 /gene="trnJ-Pro" /locus_tag="BSU_tRNA_19" /product="tRNA-Pro" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Pro(UGG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnJ-Pro tRNA" gene 95651..95727 /gene="trnJ-Pro" /locus_tag="BSU_tRNA_19" /label="trnJ-Pro gene" tRNA 95737..95812 /gene="trnJ-Ala" /locus_tag="BSU_tRNA_20" /product="tRNA-Ala" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ala(UGC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnJ-Ala tRNA" gene 95737..95812 /gene="trnJ-Ala" /locus_tag="BSU_tRNA_20" /label="trnJ-Ala gene" rRNA 95983..97536 /gene="rrnW-16S" /locus_tag="BSU_rRNA_9" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnW-16S rRNA" gene 95983..97536 /gene="rrnW-16S" /locus_tag="BSU_rRNA_9" /label="rrnW-16S gene" rRNA 97701..100628 /gene="rrnW-23S" /locus_tag="BSU_rRNA_10" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnW-23S rRNA" gene 97701..100628 /gene="rrnW-23S" /locus_tag="BSU_rRNA_10" /label="rrnW-23S gene" rRNA 100684..100802 /gene="rrnW-5S" /locus_tag="BSU_rRNA_11" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnW-5S rRNA" gene 100684..100802 /gene="rrnW-5S" /locus_tag="BSU_rRNA_11" /label="rrnW-5S gene" S_feature 100803..100880 /Source="Nicolas_S_feature" /locus_tag="new_101212_101289" /HighExp="G135, G180, G150, Cold, Paraq, Oxctl, H2O2, C30, BMM, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S44" promotor_-35 100850..100853 /Source="Nicolas_upshift_promotors" /id="U79" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.37962037962038" /psig="0.947052947052947" /xcortree=1441 /SigmaFactorBS="gctgggttttttgtattttggtttattgGTATcataaaattc cacttAACTGTATAATATAATAACTttataccgaattttaaatcagcaatcaggtttt g" /listShort="ctsR, mcsA, mcsB, clpC" /listLong="radA, disA, S45, yacL, ispD, ispF, gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" promotor_-10 100869..100888 /Source="Nicolas_upshift_promotors" /id="U79" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.37962037962038" /psig="0.947052947052947" /xcortree=1441 /SigmaFactorBS="gctgggttttttgtattttggtttattgGTATcataaaattc cacttAACTGTATAATATAATAACTttataccgaattttaaatcagcaatcaggtttt g" /listShort="ctsR, mcsA, mcsB, clpC" /listLong="radA, disA, S45, yacL, ispD, ispF, gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" upshifts 100882 /Source="Nicolas_upshifts" /id="U79" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.37962037962038" /psig="0.947052947052947" /xcortree=1441 /SigmaFactorBS="gctgggttttttgtattttggtttattgGTATcataaaattc cacttAACTGTATAATATAATAACTttataccgaattttaaatcagcaatcaggtttt g" /listShort="ctsR, mcsA, mcsB, clpC" /listLong="radA, disA, S45, yacL, ispD, ispF, gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="upshifts" promotor_-35 100916..100922 /Source="Nicolas_upshift_promotors" /id="U80" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=150 /SigmaFactorBS="ctttataccgaattttaaatcagcaatcaGGTTTTGtggacc gggaaaaTGGAAATAATGAAGGATAGAgcgagaaagttgaaaattctcgagaaacggc t" /listShort="ctsR, mcsA, mcsB, clpC, radA, disA, S45, yacL, ispD, ispF" /listLong="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /label="promotor_-35" promotor_-10 100936..100955 /Source="Nicolas_upshift_promotors" /id="U80" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=150 /SigmaFactorBS="ctttataccgaattttaaatcagcaatcaGGTTTTGtggacc gggaaaaTGGAAATAATGAAGGATAGAgcgagaaagttgaaaattctcgagaaacggc t" /listShort="ctsR, mcsA, mcsB, clpC, radA, disA, S45, yacL, ispD, ispF" /listLong="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /label="promotor_-10" upshifts 100947 /Source="Nicolas_upshifts" /id="U80" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=150 /SigmaFactorBS="ctttataccgaattttaaatcagcaatcaGGTTTTGtggacc gggaaaaTGGAAATAATGAAGGATAGAgcgagaaagttgaaaattctcgagaaacggc t" /listShort="ctsR, mcsA, mcsB, clpC, radA, disA, S45, yacL, ispD, ispF" /listLong="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /label="upshifts" promotor_-35 100962..100969 /Source="Nicolas_upshift_promotors" /id="U81" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.736263736263736" /psig=1 /xcortree=2024 /SigmaFactorBS="atggaaataatgaaggatagagcgagaAAGTTGAAaattctc gagaaaCGGCTTATAGTAAGATTAAAgtcaaatatagtcaaagtcagtaaaggagggg g" /listShort="ctsR, mcsA, mcsB, clpC, radA, disA, S45, yacL, ispD, ispF" /listLong="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" promotor_-10 100983..101002 /Source="Nicolas_upshift_promotors" /id="U81" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.736263736263736" /psig=1 /xcortree=2024 /SigmaFactorBS="atggaaataatgaaggatagagcgagaAAGTTGAAaattctc gagaaaCGGCTTATAGTAAGATTAAAgtcaaatatagtcaaagtcagtaaaggagggg g" /listShort="ctsR, mcsA, mcsB, clpC, radA, disA, S45, yacL, ispD, ispF" /listLong="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" upshifts 100995 /Source="Nicolas_upshifts" /id="U81" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.736263736263736" /psig=1 /xcortree=2024 /SigmaFactorBS="atggaaataatgaaggatagagcgagaAAGTTGAAaattctc gagaaaCGGCTTATAGTAAGATTAAAgtcaaatatagtcaaagtcagtaaaggagggg g" /listShort="ctsR, mcsA, mcsB, clpC, radA, disA, S45, yacL, ispD, ispF" /listLong="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="upshifts" CDS 101040..101504 /gene="ctsR" /locus_tag="BSU_00830" /old_locus_tag="BSU00830" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:2120829, 9852015, 11069659, 12618461, 16163393, 20852588, 24465625, 27388279" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2120829, 9852015, 11069659, 12618461, 16163393, 20852588, 24465625, 27388279; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of class III stress genes" /protein_id="NP_387964.1" /db_xref="EnsemblGenomes-Gn:BSU00830" /db_xref="EnsemblGenomes-Tr:CAB11859" /db_xref="GOA:P37568" /db_xref="InterPro:IPR008463" /db_xref="SubtiList:BG10145" /db_xref="UniProtKB/Swiss-Prot:P37568" /translation="MGHNISDIIEQYLKRVLDQNGKEILEIKRSEIADKFQCVPSQIN YVINTRFTSERGYIVESKRGGGGYIRIIKIKMNNEVVLINNIISQINTHLSQAASDDI ILRLLEDKVISEREAKMMVSVMDRSVLHIDLPERDELRARMMKAMLTSLKLK*" /label="ctsR CDS" gene 101040..101504 /gene="ctsR" /locus_tag="BSU_00830" /old_locus_tag="BSU00830" /label="ctsR gene" misc_feature complement(101151..101155) /Source="Nicolas_upshift_promotors" /id="U82" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.811188811188811" /psig="0.0769230769230769" /xcortree=50 /SigmaFactorBS="caacaatatatcctctttcgcttgtaaatctggtgttgatga cataatttatttgggaaggaACGCAttgaaatttatctgcaatttcacttcgtttaat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(101157) /Source="Nicolas_upshifts" /id="U82" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.811188811188811" /psig="0.0769230769230769" /xcortree=50 /SigmaFactorBS="caacaatatatcctctttcgcttgtaaatctggtgttgatga cataatttatttgggaaggaACGCAttgaaatttatctgcaatttcacttcgtttaat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 101518..102075 /gene="mcsA" /locus_tag="BSU_00840" /old_locus_tag="BSU00840" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16163393, 19189946, 24947607" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16163393, 19189946, 24947607; Product type f: factor" /codon_start=1 /transl_table=11 /product="activator of protein kinase McsB" /protein_id="NP_387965.1" /db_xref="EnsemblGenomes-Gn:BSU00840" /db_xref="EnsemblGenomes-Tr:CAB11860" /db_xref="GOA:P37569" /db_xref="InterPro:IPR001943" /db_xref="InterPro:IPR025542" /db_xref="InterPro:IPR029037" /db_xref="InterPro:IPR036876" /db_xref="SubtiList:BG10146" /db_xref="UniProtKB/Swiss-Prot:P37569" /translation="MICQECHERPATFHFTKVVNGEKIEVHICEQCAKENSDSYGISA NQGFSIHNLLSGLLNMDSSFQNAGTQMFSHSEQISACPKCGMTFQQFRKIGRFGCSEC YKTFHSNITPILRKVHSGNTVHAGKIPKRIGGNLHVRRQIDMLKKELESLIHQEEFEN AAHVRDQIRLLEQSLKSTDSEEEQE*" /label="mcsA CDS" gene 101518..102075 /gene="mcsA" /locus_tag="BSU_00840" /old_locus_tag="BSU00840" /label="mcsA gene" CDS 102075..103166 /gene="mcsB" /locus_tag="BSU_00850" /old_locus_tag="BSU00850" /EC_number="2.7.3.3" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16163393, 17380125, 19189946, 21622759, 25610436, 27749819" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16163393, 17380125, 19189946, 21622759, 25610436, 27749819; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="protein arginine kinase" /protein_id="NP_387966.1" /db_xref="EnsemblGenomes-Gn:BSU00850" /db_xref="EnsemblGenomes-Tr:CAB11861" /db_xref="GOA:P37570" /db_xref="InterPro:IPR000749" /db_xref="InterPro:IPR014746" /db_xref="InterPro:IPR022414" /db_xref="InterPro:IPR022415" /db_xref="InterPro:IPR023660" /db_xref="SubtiList:BG10147" /db_xref="UniProtKB/Swiss-Prot:P37570" /translation="MSLKHFIQDALSSWMKQKGPESDIVLSSRIRLARNFEHIRFPTR YSNEEASSIIQQFEDQFSEQEIPGIGKFVLIRMNDAQPLEKRVLVEKHLISPNLTESP FGGCLLSENEEVSVMLNEEDHIRIQCLFPGFQLLEAMKAANQVDDWIEEKVDYAFNEQ RGYLTSCPTNVGTGLRASVMMHLPALVLTRQINRIIPAINQLGLVVRGIYGEGSEAVG NIFQISNQITLGKSEQDIVEDLNSVAAQLIEQERSAREAIYQTSKIELEDRVYRSYGV LSNCRMIESKETAKCLSDVRLGIDLGIIKGLSSNILNELMILTQPGFLQQYSGGALRP NERDIRRAALIRERLHLEMNGKRQEDESI*" /label="mcsB CDS" gene 102075..103166 /gene="mcsB" /locus_tag="BSU_00850" /old_locus_tag="BSU00850" /label="mcsB gene" CDS 103163..105595 /gene="clpC" /locus_tag="BSU_00860" /old_locus_tag="BSU00860" /function="16.6: Maintain" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12354604, 15529410, 16525504, 26735940, 27749819" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354604, 15529410, 16525504, 26735940, 27749819; Product type f: factor" /codon_start=1 /transl_table=11 /product="class III stress response-related ATPase, AAA+ superfamily" /protein_id="NP_387967.1" /db_xref="EnsemblGenomes-Gn:BSU00860" /db_xref="EnsemblGenomes-Tr:CAB11862" /db_xref="GOA:P37571" /db_xref="InterPro:IPR001270" /db_xref="InterPro:IPR001943" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR004176" /db_xref="InterPro:IPR018368" /db_xref="InterPro:IPR019489" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR028299" /db_xref="InterPro:IPR036628" /db_xref="PDB:2K77" /db_xref="PDB:2Y1Q" /db_xref="PDB:2Y1R" /db_xref="PDB:3J3R" /db_xref="PDB:3J3S" /db_xref="PDB:3J3T" /db_xref="PDB:3J3U" /db_xref="PDB:3PXG" /db_xref="PDB:3PXI" /db_xref="PDB:5HBN" /db_xref="SubtiList:BG10148" /db_xref="UniProtKB/Swiss-Prot:P37571" /translation="MMFGRFTERAQKVLALAQEEALRLGHNNIGTEHILLGLVREGEG IAAKALQALGLGSEKIQKEVESLIGRGQEMSQTIHYTPRAKKVIELSMDEARKLGHSY VGTEHILLGLIREGEGVAARVLNNLGVSLNKARQQVLQLLGSNETGSSAAGTNSNANT PTLDSLARDLTAIAKEDSLDPVIGRSKEIQRVIEVLSRRTKNNPVLIGEPGVGKTAIA EGLAQQIINNEVPEILRDKRVMTLDMGTVVAGTKYRGEFEDRLKKVMDEIRQAGNIIL FIDELHTLIGAGGAEGAIDASNILKPSLARGELQCIGATTLDEYRKYIEKDAALERRF QPIQVDQPSVDESIQILQGLRDRYEAHHRVSITDDAIEAAVKLSDRYISDRFLPDKAI DLIDEAGSKVRLRSFTTPPNLKELEQKLDEVRKEKDAAVQSQEFEKAASLRDTEQRLR EQVEDTKKSWKEKQGQENSEVTVDDIAMVVSSWTGVPVSKIAQTETDKLLNMENILHS RVIGQDEAVVAVAKAVRRARAGLKDPKRPIGSFIFLGPTGVGKTELARALAESIFGDE ESMIRIDMSEYMEKHSTSRLVGSPPGYVGYDEGGQLTEKVRRKPYSVVLLDEIEKAHP DVFNILLQVLEDGRLTDSKGRTVDFRNTILIMTSNVGASELKRNKYVGFNVQDETQNH KDMKDKVMGELKRAFRPEFINRIDEIIVFHSLEKKHLTEIVSLMSDQLTKRLKEQDLS IELTDAAKAKVAEEGVDLEYGARPLRRAIQKHVEDRLSEELLRGNIHKGQHIVLDVED GEFVVKTTAKTN*" /label="clpC CDS" gene 103163..105595 /gene="clpC" /locus_tag="BSU_00860" /old_locus_tag="BSU00860" /label="clpC gene" downshifts 105590 /Source="Nicolas_upshifts" /id="D38" /incds=0 /nref=57 /ntot=245 /MaxReadThrough="6.69446" /MaxDrop="4.4703" /score="-8.32149463" /energy="-11.7" /TU="U80,U81" /idTUdmin="U79" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS 105687..107063 /gene="radA" /locus_tag="BSU_00870" /old_locus_tag="BSU00870" /EC_number="2.1.1.63" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 10931349, 11810266, 15317759, 25616256; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA repair protein; 6-O-methylguanine-DNA methyltransferase" /protein_id="NP_387968.1" /db_xref="EnsemblGenomes-Gn:BSU00870" /db_xref="EnsemblGenomes-Tr:CAB11863" /db_xref="GOA:P37572" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004504" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR020588" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10149" /db_xref="UniProtKB/Swiss-Prot:P37572" /translation="MAKTKSKFICQSCGYESPKWMGKCPGCGAWNTMVEEMIKKAPAN RRAAFSHSVQTVQKPSPITSIETSEEPRVKTQLGEFNRVLGGGVVKGSLVLIGGDPGI GKSTLLLQVSAQLSGSSNSVLYISGEESVKQTKLRADRLGINNPSLHVLSETDMEYIS SAIQEMNPSFVVVDSIQTVYQSDITSAPGSVSQVRECTAELMKIAKTKGIPIFIVGHV TKEGSIAGPRLLEHMVDTVLYFEGERHHTFRILRAVKNRFGSTNEMGIFEMREEGLTE VLNPSEIFLEERSAGSAGSSITASMEGTRPILVEIQALISPTSFGNPRRMATGIDHNR VSLLMAVLEKRVGLLLQNQDAYLKVAGGVKLDEPAIDLAIVISIASSFRDTPPNPADC FIGEVGLTGEVRRVSRIEQRVKEAAKLGFKRMIIPAANLDGWTKPKGIEVIGVANVAE ALRTSLGG*" /label="radA CDS" gene 105687..107063 /gene="radA" /locus_tag="BSU_00870" /old_locus_tag="BSU00870" /label="radA gene" promotor_-35 106142..106151 /Source="Nicolas_upshift_promotors" /id="U83" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1648 /SigmaFactorBS="ctcggcattaataatccgtcactgcatgttttatcTGAAACC GATatggagtatattTCGTCTGCTATACAAGagatgaatccatcgtttgtcgttgttg a" /listShort="disA, S45, yacL, ispD, ispF, gltX, S46, cysE, cysS, mrnC, rlmB, yacP" /listLong="sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" promotor_-10 106164..106179 /Source="Nicolas_upshift_promotors" /id="U83" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1648 /SigmaFactorBS="ctcggcattaataatccgtcactgcatgttttatcTGAAACC GATatggagtatattTCGTCTGCTATACAAGagatgaatccatcgtttgtcgttgttg a" /listShort="disA, S45, yacL, ispD, ispF, gltX, S46, cysE, cysS, mrnC, rlmB, yacP" /listLong="sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" upshifts 106167 /Source="Nicolas_upshifts" /id="U83" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1648 /SigmaFactorBS="ctcggcattaataatccgtcactgcatgttttatcTGAAACC GATatggagtatattTCGTCTGCTATACAAGagatgaatccatcgtttgtcgttgttg a" /listShort="disA, S45, yacL, ispD, ispF, gltX, S46, cysE, cysS, mrnC, rlmB, yacP" /listLong="sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="upshifts" CDS 107067..108149 /gene="disA" /locus_tag="BSU_00880" /old_locus_tag="BSU00880" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16713562, 21566650, 24939848, 25616256, 27074767, 27150552, 28511132, 28961460" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16713562, 21566650, 24939848, 25616256, 27074767, 27150552, 28511132, 28961460; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="diadenylate cyclase; DNA integrity scanning protein; cell cycle checkpoint DNA scanning protein" /protein_id="NP_387969.1" /db_xref="EnsemblGenomes-Gn:BSU00880" /db_xref="EnsemblGenomes-Tr:CAB11864" /db_xref="GOA:P37573" /db_xref="InterPro:IPR003390" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR018906" /db_xref="InterPro:IPR023763" /db_xref="InterPro:IPR036888" /db_xref="SubtiList:BG10150" /db_xref="UniProtKB/Swiss-Prot:P37573" /translation="MEKEKKGAKHELDLSSILQFVAPGTPLRAGMENVLRANTGGLIV VGYNDKVKEVVDGGFHINTAFSPAHLYELAKMDGAIILSDSGQKILYANTQLMPDATI SSSETGMRHRTAERVAKQTGCLVIAISERRNVITLYQENMKYTLKDIGFILTKANQAI QTLEKYKTILDKTINALNALEFEELVTFSDVLSVMHRYEMVLRIKNEINMYIKELGTE GHLIKLQVIELITDMEEEAALFIKDYVKEKIKDPFVLLKELQDMSSYDLLDDSIVYKL LGYPASTNLDDYVLPRGYRLLNKIPRLPMPIVENVVEAFGVLPRIIEASAEELDEVEG IGEVRAQKIKKGLKRLQEKHYLDRQL*" /label="disA CDS" gene 107067..108149 /gene="disA" /locus_tag="BSU_00880" /old_locus_tag="BSU00880" /label="disA gene" S_feature 108150..108264 /Source="Nicolas_S_feature" /locus_tag="new_108559_108673" /HighExp="Etha, Salt, Heat, dia15, Diami, M9-stat, B60, T-0.40H, T-1.10H, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY, SigA, SigB" /TUshortPSig="1, 1, 1" /TUlongSig="SigA" /TUlongPSig="0.947" /label="S45" CDS 108265..109365 /gene="yacL" /locus_tag="BSU_00890" /old_locus_tag="BSU00890" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26999498; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein possibly involved in RNA binding" /protein_id="NP_387970.1" /db_xref="EnsemblGenomes-Gn:BSU00890" /db_xref="EnsemblGenomes-Tr:CAB11865" /db_xref="GOA:Q06754" /db_xref="InterPro:IPR002716" /db_xref="InterPro:IPR002792" /db_xref="InterPro:IPR029060" /db_xref="SubtiList:BG10151" /db_xref="UniProtKB/Swiss-Prot:Q06754" /translation="MLKRIVQAFFIIFGGVVGIFLIPELFVLLNIQDIPLITNAYTSA AIGAIIFFLISIWGTEYVVNWVKWIEDSLLKAPVPDLLFGSLGLVFGLIIAYLIVNVI PLDNIPYRIFSTIIPVFLAFFLGYLGFQVGFKKKDELISLFSISARMQKKKGTADEEH EVQDKKLKILDTSVIIDGRIADICQTGFLEGVIVIPQFVLEELQHIADSSDVLKRNRG RRGLDILNRIQKELDIEVEIYEGDFEDIQEVDSKLVKLAKLTSGVVVTNDFNLNKVCE LQKVAVLNINDLANAVKPVVLPGEEMNVQVIKDGKEHNQGVAYLDDGTMIVVEEGRNY IGKHIDVLVTSVLQTAAGRMIFAKPKLLEKAL*" /label="yacL CDS" gene 108265..109365 /gene="yacL" /locus_tag="BSU_00890" /old_locus_tag="BSU00890" /label="yacL gene" downshifts complement(109187) /Source="Nicolas_upshifts" /id="D39" /incds=1 /nref=1 /ntot=103 /MaxReadThrough="0.39171" /MaxDrop="2.87304" /score="-9.71423487" /energy="-11.8" /TU="NA" /idTUdmin="U82" /TUdmin="-8228" /isTUend="FALSE" /label="downshifts" CDS 109380..110078 /gene="ispD" /locus_tag="BSU_00900" /old_locus_tag="BSU00900" /EC_number="2.7.7.60" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15044829, 15379557, 16533036, 17081012, 17458547, 23840410, 27821871" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15044829, 15379557, 16533036, 17081012, 17458547, 23840410, 27821871; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, nonmevalonate isoprenoid pathway" /protein_id="NP_387971.1" /db_xref="EnsemblGenomes-Gn:BSU00900" /db_xref="EnsemblGenomes-Tr:CAB11866" /db_xref="GOA:Q06755" /db_xref="InterPro:IPR001228" /db_xref="InterPro:IPR018294" /db_xref="InterPro:IPR029044" /db_xref="InterPro:IPR034683" /db_xref="PDB:5DDT" /db_xref="PDB:5DDV" /db_xref="PDB:5HS2" /db_xref="SubtiList:BG10152" /db_xref="UniProtKB/Swiss-Prot:Q06755" /translation="MSYDVVIPAAGQGKRMKAGRNKLFIELKGDPVIIHTLRVFDSHR QCDKIILVINEQEREHFQQLLSDYPFQTSIELVAGGDERQHSVYKGLKAVKQEKIVLV HDGARPFIKHEQIDELIAEAEQTGAAILAVPVKDTIKRVQDLQVSETIERSSLWAVQT PQAFRLSLLMKAHAEAERKGFLGTDDASLVEQMEGGSVRVVEGSYTNIKLTTPDDLTS AEAIMESESGNKHV*" /label="ispD CDS" gene 109380..110078 /gene="ispD" /locus_tag="BSU_00900" /old_locus_tag="BSU00900" /label="ispD gene" CDS 110071..110547 /gene="ispF" /locus_tag="BSU_00910" /old_locus_tag="BSU00910" /EC_number="4.6.1.12" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9622350, 11997478, 12270818, 12682299, 17458547, 23840410" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9622350, 11997478, 12270818, 12682299, 17458547, 23840410; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase" /protein_id="NP_387972.1" /db_xref="EnsemblGenomes-Gn:BSU00910" /db_xref="EnsemblGenomes-Tr:CAB11867" /db_xref="GOA:Q06756" /db_xref="InterPro:IPR003526" /db_xref="InterPro:IPR020555" /db_xref="InterPro:IPR036571" /db_xref="PDB:5IWX" /db_xref="PDB:5IWY" /db_xref="SubtiList:BG10153" /db_xref="UniProtKB/Swiss-Prot:Q06756" /translation="MFRIGQGFDVHQLVEGRPLIIGGIEIPYEKGLLGHSDADVLLHT VADACLGAVGEGDIGKHFPDTDPEFKDADSFKLLQHVWGIVKQKGYVLGNIDCTIIAQ KPKMLPYIEDMRKRIAEGLEADVSQVNVKATTTEKLGFTGRAEGIAAQATVLIQKG*" /label="ispF CDS" gene 110071..110547 /gene="ispF" /locus_tag="BSU_00910" /old_locus_tag="BSU00910" /label="ispF gene" promotor_-35 110551..110558 /Source="Nicolas_upshift_promotors" /id="U84" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.606393606393606" /psig="0.999000999001" /xcortree=2679 /SigmaFactorBS="cagtactgatacaaaaaggctaacttGTTTTGATgccgggtc tatttGGTGGTAGAATAGATTCATAcatttttgcctgaggccatacatgacatgaaag g" /listShort="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG" /listLong="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" promotor_-10 110572..110591 /Source="Nicolas_upshift_promotors" /id="U84" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.606393606393606" /psig="0.999000999001" /xcortree=2679 /SigmaFactorBS="cagtactgatacaaaaaggctaacttGTTTTGATgccgggtc tatttGGTGGTAGAATAGATTCATAcatttttgcctgaggccatacatgacatgaaag g" /listShort="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG" /listLong="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" upshifts 110585 /Source="Nicolas_upshifts" /id="U84" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.606393606393606" /psig="0.999000999001" /xcortree=2679 /SigmaFactorBS="cagtactgatacaaaaaggctaacttGTTTTGATgccgggtc tatttGGTGGTAGAATAGATTCATAcatttttgcctgaggccatacatgacatgaaag g" /listShort="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG" /listLong="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="upshifts" CDS 110638..112089 /gene="gltX" /locus_tag="BSU_00920" /old_locus_tag="BSU00920" /EC_number="6.1.1.24" /EC_number="6.1.1.17" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2120226, 3079749, 9342321, 10024179, 10546897, 12682299, 14741355" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2120226, 3079749, 9342321, 10024179, 10546897, 12682299, 14741355; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamyl-tRNA synthetase" /protein_id="NP_387973.1" /db_xref="EnsemblGenomes-Gn:BSU00920" /db_xref="EnsemblGenomes-Tr:CAB11868" /db_xref="GOA:P22250" /db_xref="InterPro:IPR000924" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR004527" /db_xref="InterPro:IPR008925" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR020058" /db_xref="InterPro:IPR020061" /db_xref="InterPro:IPR020751" /db_xref="InterPro:IPR020752" /db_xref="InterPro:IPR033910" /db_xref="SubtiList:BG10154" /db_xref="UniProtKB/Swiss-Prot:P22250" /translation="MGNEVRVRYAPSPTGHLHIGNARTALFNYLFARNQGGKFIIRVE DTDKKRNIEGGEQSQLNYLKWLGIDWDESVDVGGEYGPYRQSERNDIYKVYYEELLEK GLAYKCYCTEEELEKEREEQIARGEMPRYSGKHRDLTQEEQEKFIAEGRKPSIRFRVP EGKVIAFNDIVKGEISFESDGIGDFVIVKKDGTPTYNFAVAIDDYLMKMTHVLRGEDH ISNTPKQIMIYQAFGWDIPQFGHMTLIVNESRKKLSKRDESIIQFIEQYKELGYLPEA LFNFIGLLGWSPVGEEELFTKEQFIEIFDVNRLSKSPALFDMHKLKWVNNQYVKKLDL DQVVELTLPHLQKAGKVGTELSAEEQEWVRKLISLYHEQLSYGAEIVELTDLFFTDEI EYNQEAKAVLEEEQVPEVLSTFAAKLEELEEFTPDNIKASIKAVQKETGHKGKKLFMP IRVAVTGQTHGPELPQSIELIGKETAIQRLKNI*" /label="gltX CDS" gene 110638..112089 /gene="gltX" /locus_tag="BSU_00920" /old_locus_tag="BSU00920" /label="gltX gene" promotor_-35 111567..111576 /Source="Nicolas_upshift_promotors" /id="U85" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1307 /SigmaFactorBS="agcagtttattgaaatttttgatgtaaatcgtttatcTAAAT CACCAgctttgtttgataTGCATAAGCTAAAATGGGTTaacaaccaatatgtgaagaa g" /listShort="S46, cysE, cysS, mrnC, rlmB, yacP" /listLong="sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA" /label="promotor_-35" promotor_-10 111590..111609 /Source="Nicolas_upshift_promotors" /id="U85" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1307 /SigmaFactorBS="agcagtttattgaaatttttgatgtaaatcgtttatcTAAAT CACCAgctttgtttgataTGCATAAGCTAAAATGGGTTaacaaccaatatgtgaagaa g" /listShort="S46, cysE, cysS, mrnC, rlmB, yacP" /listLong="sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA" /label="promotor_-10" upshifts 111590 /Source="Nicolas_upshifts" /id="U85" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1307 /SigmaFactorBS="agcagtttattgaaatttttgatgtaaatcgtttatcTAAAT CACCAgctttgtttgataTGCATAAGCTAAAATGGGTTaacaaccaatatgtgaagaa g" /listShort="S46, cysE, cysS, mrnC, rlmB, yacP" /listLong="sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA" /label="upshifts" S_feature 112090..112390 /Source="Nicolas_S_feature" /locus_tag="new_112499_112799" /HighExp="S6, S8, S7, Diami, C90, LBGexp, G135, H2O2, dia5, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.17844199999999999" /TUshortSig="SigK, SigA, SigWXY" /TUshortPSig="1, 0.999, 1" /TUlongSig="SigA, SigB, SigA" /TUlongPSig="1, 1, 0.947" /label="S46" CDS 112391..113044 /gene="cysE" /locus_tag="BSU_00930" /old_locus_tag="BSU00930" /EC_number="2.3.1.30" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7510287, 10737181, 10939241, 17056751, 18974048, 25731080" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7510287, 10737181, 10939241, 17056751, 18974048, 25731080; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="serine O-acetyltransferase" /protein_id="NP_387974.1" /db_xref="EnsemblGenomes-Gn:BSU00930" /db_xref="EnsemblGenomes-Tr:CAB11869" /db_xref="GOA:Q06750" /db_xref="InterPro:IPR001451" /db_xref="InterPro:IPR005881" /db_xref="InterPro:IPR010493" /db_xref="InterPro:IPR011004" /db_xref="InterPro:IPR018357" /db_xref="SubtiList:BG10155" /db_xref="UniProtKB/Swiss-Prot:Q06750" /translation="MFFRMLKEDIDTVFDQDPAARSYFEVILTYSGLHAIWAHRIAHA LYKRKFYFLARLISQVSRFFTGIEIHPGATIGRRFFIDHGMGVVIGETCEIGNNVTVF QGVTLGGTGKEKGKRHPTIKDDALIATGAKVLGSITVGEGSKIGAGSVVLHDVPDFST VVGIPGRVVVQNGKKVRRDLNHQDLPDPVADRFKSLEQQILELKAELEDRKERINQK* " /label="cysE CDS" gene 112391..113044 /gene="cysE" /locus_tag="BSU_00930" /old_locus_tag="BSU00930" /label="cysE gene" CDS 113041..114441 /gene="cysS" /locus_tag="BSU_00940" /old_locus_tag="BSU00940" /EC_number="6.1.1.16" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10024179, 10546897, 10931887, 12682299, 29079736" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10024179, 10546897, 10931887, 12682299, 29079736; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dual cysteinyl-tRNA synthetase; cysteine persulfide synthase" /protein_id="NP_387975.1" /db_xref="EnsemblGenomes-Gn:BSU00940" /db_xref="EnsemblGenomes-Tr:CAB11870" /db_xref="GOA:Q06752" /db_xref="InterPro:IPR009080" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR015273" /db_xref="InterPro:IPR015803" /db_xref="InterPro:IPR024909" /db_xref="InterPro:IPR032678" /db_xref="SubtiList:BG10156" /db_xref="UniProtKB/Swiss-Prot:Q06752" /translation="MTITLYNTLTRQKETFVPLEEGKVKMYVCGPTVYNYIHIGNARP AIVYDTVRNYLEYKGYDVQYVSNFTDVDDKLIKAANELGEDVPTISERFIKAYFEDVG ALGCRKADLHPRVMENMDAIIEFVDQLVKKGYAYESEGDVYFKTRAFEGYGKLSQQSI DELRSGARIRVGEKKEDALDFALWKAAKEGEISWDSPWGKGRPGWHIECSAMVKKYLG DQIDIHAGGQDLTFPHHENEIAQSEALTGKTFAKYWLHNGYINIDNEKMSKSLGNFVL VHDIIKQHDPQLLRFFMLSVHYRHPINYSEELLENTKSAFSRLKTAYSNLQHRLNSST NLTEDDDQWLEKVEEHRKAFEEEMDDDFNTANAISVLFDLAKHANYYLQKDHTADHVI TAFIEMFDRIVSVLGFSLGEQELLDQEIEDLIEKRNEARRNRDFALSDQIRDQLKSMN IILEDTAQGTRWKRGE*" /label="cysS CDS" gene 113041..114441 /gene="cysS" /locus_tag="BSU_00940" /old_locus_tag="BSU00940" /label="cysS gene" CDS 114445..114876 /gene="mrnC" /locus_tag="BSU_00950" /old_locus_tag="BSU00950" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16014871, 25634891, 27924926" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16014871, 25634891, 27924926; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease for 23S RNA maturation, mini-RNase III" /protein_id="NP_387976.1" /db_xref="EnsemblGenomes-Gn:BSU00950" /db_xref="EnsemblGenomes-Tr:CAB11871" /db_xref="GOA:O31418" /db_xref="InterPro:IPR000999" /db_xref="InterPro:IPR008226" /db_xref="InterPro:IPR036389" /db_xref="PDB:4OUN" /db_xref="SubtiList:BG12702" /db_xref="UniProtKB/Swiss-Prot:O31418" /translation="MLEFDTIKDSKQLNGLALAYIGDAIFEVYVRHHLLKQGFTKPND LHKKSSRIVSAKSQAEILFFLQNQSFFTEEEEAVLKRGRNAKSGTTPKNTDVQTYRYS TAFEALLGYLFLEKKEERLSQLVAEAIQFGTSGRKTNESAT*" /label="mrnC CDS" gene 114445..114876 /gene="mrnC" /locus_tag="BSU_00950" /old_locus_tag="BSU00950" /label="mrnC gene" CDS 114860..115609 /gene="rlmB" /locus_tag="BSU_00960" /old_locus_tag="BSU00960" /EC_number="2.1.1.185" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11698387, 12377117, 16014871; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="23S rRNA (Gm2251)-methyltransferase" /protein_id="NP_387977.1" /db_xref="EnsemblGenomes-Gn:BSU00960" /db_xref="EnsemblGenomes-Tr:CAB11872" /db_xref="GOA:Q06753" /db_xref="InterPro:IPR001537" /db_xref="InterPro:IPR004441" /db_xref="InterPro:IPR013123" /db_xref="InterPro:IPR029026" /db_xref="InterPro:IPR029028" /db_xref="InterPro:IPR029064" /db_xref="SubtiList:BG10157" /db_xref="UniProtKB/Swiss-Prot:Q06753" /translation="MSQQHDYVIGKNAVIETLKSDRKLYKLWMAENTVKGQAQQVIEL AKKQGITIQYVPRKKLDQMVTGQHQGVVAQVAAYEYAELDDLYKAAEEKNEQPFFLIL DELEDPHNLGSIMRTADAVGAHGIVIPKRRAVGLTTTVAKASTGAIEHIPVARVTNLA RTLEEMKERGIWVVGTDASAREDFRNMDGNMPLALVIGSEGKGMGRLVKEKCDFLIKL PMAGKVTSLNASVAAGLLMYEVYRKRNPVGE*" /label="rlmB CDS" gene 114860..115609 /gene="rlmB" /locus_tag="BSU_00960" /old_locus_tag="BSU00960" /label="rlmB gene" CDS 115616..116128 /gene="raeA" /locus_tag="BSU_00970" /old_locus_tag="BSU00970" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:17114934, 23355615, 28363943" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17114934, 23355615, 28363943; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosome-dependent mRNA endonuclease" /protein_id="NP_387978.1" /db_xref="EnsemblGenomes-Gn:BSU00970" /db_xref="EnsemblGenomes-Tr:CAB11873" /db_xref="InterPro:IPR010298" /db_xref="PDB:5MQ8" /db_xref="PDB:5MQ9" /db_xref="SubtiList:BG10158" /db_xref="UniProtKB/Swiss-Prot:P37574" /translation="MDILLVDGYNMIGAWPQLKDLKANSFEEARDVLIQKMAEYQSYT GNRVIVVFDAHLVKGLEKKQTNHRVEVIFTKENETADERIEKLAQALNNIATQIHVAT SDYTEQWAIFGQGALRKSARELLREVETIERRIERRVRKITSEKPAGKIALSEEVLKT FEKWRRGDLD*" /label="raeA CDS" gene 115616..116128 /gene="raeA" /locus_tag="BSU_00970" /old_locus_tag="BSU00970" /label="raeA gene" promotor_-35 116127..116134 /Source="Nicolas_upshift_promotors" /id="U86" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.71028971028971" /psig=1 /xcortree=3212 /SigmaFactorBS="aaacgtttgaaaagtggaggcggggagacttagattAAGTTG ACgcttttttgcccaaTACTGTATAATATTTCTATCtacgtgcgccggggggatcgga g" /listShort="sigH, S47, rpmGB, secE, S48, nusG" /listLong="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" promotor_-10 116149..116168 /Source="Nicolas_upshift_promotors" /id="U86" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.71028971028971" /psig=1 /xcortree=3212 /SigmaFactorBS="aaacgtttgaaaagtggaggcggggagacttagattAAGTTG ACgcttttttgcccaaTACTGTATAATATTTCTATCtacgtgcgccggggggatcgga g" /listShort="sigH, S47, rpmGB, secE, S48, nusG" /listLong="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" upshifts 116151 /Source="Nicolas_upshifts" /id="U86" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.71028971028971" /psig=1 /xcortree=3212 /SigmaFactorBS="aaacgtttgaaaagtggaggcggggagacttagattAAGTTG ACgcttttttgcccaaTACTGTATAATATTTCTATCtacgtgcgccggggggatcgga g" /listShort="sigH, S47, rpmGB, secE, S48, nusG" /listLong="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="upshifts" CDS 116191..116847 /gene="sigH" /locus_tag="BSU_00980" /old_locus_tag="BSU00980" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12169614, 16339734, 25288929, 26712348" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12169614, 16339734, 25288929, 26712348; Product type f: factor" /codon_start=1 /transl_table=11 /product="RNA polymerase sigma-30 factor (sigma(H))" /protein_id="NP_387979.1" /db_xref="EnsemblGenomes-Gn:BSU00980" /db_xref="EnsemblGenomes-Tr:CAB11874" /db_xref="GOA:P17869" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR000943" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014218" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR016371" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10159" /db_xref="UniProtKB/Swiss-Prot:P17869" /translation="MNLQNNKGKFNKEQFCQLEDEQVIEKVHVGDSDALDYLITKYRN FVRAKARSYFLIGADREDIVQEGMIGLYKSIRDFKEDKLTSFKAFAELCITRQIITAI KTATRQKHIPLNSYASLDKPIFDEESDRTLLDVISGAKTLNPEEMIINQEEFDDIEMK MGELLSDLERKVLVLYLDGRSYQEISDELNRHVKSIDNALQRVKRKLEKYLEIREISL *" /label="sigH CDS" gene 116191..116847 /gene="sigH" /locus_tag="BSU_00980" /old_locus_tag="BSU00980" /label="sigH gene" downshifts complement(116645) /Source="Nicolas_upshifts" /id="D40" /incds=1 /nref=1 /ntot=107 /MaxReadThrough="2.38622" /MaxDrop="2.50464" /score="-2.56993398" /energy="-10.3" /TU="NA" /idTUdmin="U87" /TUdmin=836 /isTUend="FALSE" /label="downshifts" S_feature 116848..116939 /Source="Nicolas_S_feature" /locus_tag="new_117257_117348" /HighExp="T4.0H, T3.30H, T3.0H, T2.30H, S1, S2, T5.0H, HiOs, T2.0H, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="SigK, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 1, 1, 0.947" /label="S47" CDS 116940..117089 /gene="rpmGB" /locus_tag="BSU_00990" /old_locus_tag="BSU00990" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14586115, 19648245, 23002217, 27561249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14586115, 19648245, 23002217, 27561249; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L33" /protein_id="NP_387980.1" /db_xref="EnsemblGenomes-Gn:BSU00990" /db_xref="EnsemblGenomes-Tr:CAB11875" /db_xref="GOA:Q06798" /db_xref="InterPro:IPR001705" /db_xref="InterPro:IPR011332" /db_xref="InterPro:IPR018264" /db_xref="SubtiList:BG10160" /db_xref="UniProtKB/Swiss-Prot:Q06798" /translation="MRKKITLACKTCGNRNYTTMKSSASAAERLEVKKYCSTCNSHTA HLETK*" /label="rpmGB CDS" gene 116940..117089 /gene="rpmGB" /locus_tag="BSU_00990" /old_locus_tag="BSU00990" /label="rpmGB gene" CDS 117123..117302 /gene="secE" /locus_tag="BSU_01000" /old_locus_tag="BSU01000" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11976315, 12682299, 16242710, 22304380, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11976315, 12682299, 16242710, 22304380, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="preprotein translocase subunit" /protein_id="NP_387981.1" /db_xref="EnsemblGenomes-Gn:BSU01000" /db_xref="EnsemblGenomes-Tr:CAB11876" /db_xref="GOA:Q06799" /db_xref="InterPro:IPR001901" /db_xref="InterPro:IPR005807" /db_xref="InterPro:IPR022943" /db_xref="SubtiList:BG10161" /db_xref="UniProtKB/Swiss-Prot:Q06799" /translation="MRIMKFFKDVGKEMKKVSWPKGKELTRYTITVISTVIFFVIFFA LLDTGISQLIRLIVE*" /label="secE CDS" gene 117123..117302 /gene="secE" /locus_tag="BSU_01000" /old_locus_tag="BSU01000" /label="secE gene" S_feature 117303..117480 /Source="Nicolas_S_feature" /locus_tag="new_117712_117889" /HighExp="Cold, G180, G150, H2O2, LoTm, Oxctl, G135, Paraq, LBGexp, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="SigK, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 1, 1, 0.947" /label="S48" downshifts complement(117474) /Source="Nicolas_upshifts" /id="D41" /incds=0 /nref=37 /ntot=175 /MaxReadThrough="1.57397" /MaxDrop="4.03552" /score="-2.56993398" /energy="-10.3" /TU="NA" /idTUdmin="U87" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS 117481..118014 /gene="nusG" /locus_tag="BSU_01010" /old_locus_tag="BSU01010" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11101662, 16014871, 16707701, 18852477, 26742846, 28507243" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11101662, 16014871, 16707701, 18852477, 26742846, 28507243; Product type f : factor" /codon_start=1 /transl_table=11 /product="RNA polymerase elongation pause factor" /protein_id="NP_387982.1" /db_xref="EnsemblGenomes-Gn:BSU01010" /db_xref="EnsemblGenomes-Tr:CAB11877" /db_xref="GOA:Q06795" /db_xref="InterPro:IPR001062" /db_xref="InterPro:IPR005824" /db_xref="InterPro:IPR006645" /db_xref="InterPro:IPR008991" /db_xref="InterPro:IPR014722" /db_xref="InterPro:IPR015869" /db_xref="InterPro:IPR036735" /db_xref="SubtiList:BG10162" /db_xref="UniProtKB/Swiss-Prot:Q06795" /translation="MEKNWYVVHTYSGYENKVKANLEKRVESMGMQDKIFRVVVPEEE ETDIKNGKKKVVKKKVFPGYVLVEIVMTDDSWYVVRNTPGVTGFVGSAGSGSKPTPLL PGEAETILKRMGMDERKTDIDFELKETVKVIDGPFANFTGSIEEIDYDKSKVKVFVNM FGRETPVELEFTQIDKL*" /label="nusG CDS" gene 117481..118014 /gene="nusG" /locus_tag="BSU_01010" /old_locus_tag="BSU01010" /label="nusG gene" upshifts complement(117569) /Source="Nicolas_upshifts" /id="U87" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.98001998001998" /psig="0.002997002997003" /xcortree=29 /SigmaFactorBS="tttttgatatccgtttcttcttcttcgggtacgACTACAcgg aaaattttatcCTGCAtccccattgattcaacacgcttttccaagttggcttttactt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(117572..117576) /Source="Nicolas_upshift_promotors" /id="U87" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.98001998001998" /psig="0.002997002997003" /xcortree=29 /SigmaFactorBS="tttttgatatccgtttcttcttcttcgggtacgACTACAcgg aaaattttatcCTGCAtccccattgattcaacacgcttttccaagttggcttttactt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(117591..117596) /Source="Nicolas_upshift_promotors" /id="U87" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.98001998001998" /psig="0.002997002997003" /xcortree=29 /SigmaFactorBS="tttttgatatccgtttcttcttcttcgggtacgACTACAcgg aaaattttatcCTGCAtccccattgattcaacacgcttttccaagttggcttttactt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 118025..118032 /Source="Nicolas_upshift_promotors" /id="U88" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.787212787212787" /psig=1 /xcortree=2652 /SigmaFactorBS="agctggaatttacccaaatcgataaattgtaatgtgaaaaaa CTTGAAATtgctatatataaaTGATAATATAGCAAAGGTACgtcttggacttatccaa g" /listShort="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" S_feature 118043..118181 /Source="Nicolas_S_feature" /locus_tag="new_118452_118590" /HighExp="T-1.40H, ferm, T-3.40H, T-5.40H, BI, B36, LoTm, SMM, T-2.40H, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigK, SigA, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 0.999, 1, 1, 1, 0.947" /label="S49" upshifts 118043 /Source="Nicolas_upshifts" /id="U88" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.787212787212787" /psig=1 /xcortree=2652 /SigmaFactorBS="agctggaatttacccaaatcgataaattgtaatgtgaaaaaa CTTGAAATtgctatatataaaTGATAATATAGCAAAGGTACgtcttggacttatccaa g" /listShort="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="upshifts" promotor_-10 118046..118065 /Source="Nicolas_upshift_promotors" /id="U88" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.787212787212787" /psig=1 /xcortree=2652 /SigmaFactorBS="agctggaatttacccaaatcgataaattgtaatgtgaaaaaa CTTGAAATtgctatatataaaTGATAATATAGCAAAGGTACgtcttggacttatccaa g" /listShort="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" CDS 118182..118607 /gene="rplK" /locus_tag="BSU_01020" /old_locus_tag="BSU01020" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11244072, 19653700, 20441189" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11244072, 19653700, 20441189; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L11 (BL11)" /protein_id="NP_387983.2" /db_xref="EnsemblGenomes-Gn:BSU01020" /db_xref="EnsemblGenomes-Tr:CAB11878" /db_xref="GOA:Q06796" /db_xref="InterPro:IPR000911" /db_xref="InterPro:IPR006519" /db_xref="InterPro:IPR020783" /db_xref="InterPro:IPR020784" /db_xref="InterPro:IPR020785" /db_xref="InterPro:IPR036769" /db_xref="InterPro:IPR036796" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="SubtiList:BG10163" /db_xref="UniProtKB/Swiss-Prot:Q06796" /translation="MAKKVVKVVKLQIPAGKANPAPPVGPALGQAGVNIMGFCKEFNA RTADQAGLIIPVEISVYEDRSFTFITKTPPAAVLLKKAAGIESGSGEPNRNKVATVKR DKVREIAETKMPDLNAADVEAAMRMVEGTARSMGIVIED*" /label="rplK CDS" gene 118182..118607 /gene="rplK" /locus_tag="BSU_01020" /old_locus_tag="BSU01020" /label="rplK gene" S_feature 118608..118701 /Source="Nicolas_S_feature" /locus_tag="new_119017_119110" /HighExp="HPh, LPh, Lbexp, G180, LBGexp, G150, Heat, Cold, Fru, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigK, SigA, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 0.999, 1, 1, 1, 0.947" /label="S50" CDS 118702..119400 /gene="rplA" /locus_tag="BSU_01030" /old_locus_tag="BSU01030" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 16352840, 17981968, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L1 (BL1)" /protein_id="NP_387984.2" /db_xref="EnsemblGenomes-Gn:BSU01030" /db_xref="EnsemblGenomes-Tr:CAB11879" /db_xref="GOA:Q06797" /db_xref="InterPro:IPR002143" /db_xref="InterPro:IPR005878" /db_xref="InterPro:IPR016095" /db_xref="InterPro:IPR023673" /db_xref="InterPro:IPR023674" /db_xref="InterPro:IPR028364" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="SubtiList:BG10164" /db_xref="UniProtKB/Swiss-Prot:Q06797" /translation="MAKKGKKYVEAAKLVDRSKAYDVSEAVALVKKTNTAKFDATVEV AFRLGVDPRKNDQQIRGAVVLPNGTGKTQRVLVFAKGEKAKEAEAAGADFVGDTDYIN KIQQGWFDFDVIVATPDMMGEVGKIGRVLGPKGLMPNPKTGTVTFEVEKAIGEIKAGK VEYRVDKAGNIHVPIGKVSFEDEKLVENFTTMYDTILKAKPAAAKGVYVKNVAVTSTM GPGVKVDSSTFNVK*" /label="rplA CDS" gene 118702..119400 /gene="rplA" /locus_tag="BSU_01030" /old_locus_tag="BSU01030" /label="rplA gene" downshifts complement(119374) /Source="Nicolas_upshifts" /id="D42" /incds=0 /nref=3 /ntot=95 /MaxReadThrough="3.54108" /MaxDrop="3.36566" /score="-2.56993398" /energy="-10.3" /TU="NA" /idTUdmin="U89" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_RNA 119446..119586 /gene="ldlJ" /locus_tag="BSU_misc_RNA_3" /product="L10_leader" /experiment="publication(s) with functional evidences, PMID:26101249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 26101249; Product type n: RNA" /label="ldlJ RNA" gene 119446..119586 /gene="ldlJ" /locus_tag="BSU_misc_RNA_3" /label="ldlJ gene" upshifts complement(119462) /Source="Nicolas_upshifts" /id="U89" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.603396603396603" /psig="0.248751248751249" /xcortree=60 /SigmaFactorBS="gctgtgataatatacacctcggtaggataattaagcggttag gcccctactgtCTACGgtataaatgatattctattttacaacattttgaataatatca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(119465..119469) /Source="Nicolas_upshift_promotors" /id="U89" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.603396603396603" /psig="0.248751248751249" /xcortree=60 /SigmaFactorBS="gctgtgataatatacacctcggtaggataattaagcggttag gcccctactgtCTACGgtataaatgatattctattttacaacattttgaataatatca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" downshifts 119518 /Source="Nicolas_upshifts" /id="D43" /incds=1 /nref=1 /ntot=19 /MaxReadThrough="9.14839" /MaxDrop="2.9211" /score="20.0562348" /energy="-13.2" /TU="U88" /idTUdmin="U84" /TUdmin=1497 /isTUend="FALSE" /label="downshifts" CDS 119652..120152 /gene="rplJ" /locus_tag="BSU_01040" /old_locus_tag="BSU01040" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9810686, 11341315, 12682299, 18247578, 26101249, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9810686, 11341315, 12682299, 18247578, 26101249, 22720735; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L10 (BL5)" /protein_id="NP_387985.2" /db_xref="EnsemblGenomes-Gn:BSU01040" /db_xref="EnsemblGenomes-Tr:CAB11880" /db_xref="GOA:P42923" /db_xref="InterPro:IPR001790" /db_xref="InterPro:IPR002363" /db_xref="InterPro:IPR022973" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11220" /db_xref="UniProtKB/Swiss-Prot:P42923" /translation="MSSAIETKKVVVEEIASKLKESKSTIIVDYRGLNVSEVTELRKQ LREANVEFKVYKNTMTRRAVEQAELNGLNDFLTGPNAIAFSTEDVVAPAKVLNDFAKN HEALEIKAGVIEGKVSTVEEVKALAELPSREGLLSMLLSVLQAPVRNLALAAKAVAEQ KEEQGA*" /label="rplJ CDS" gene 119652..120152 /gene="rplJ" /locus_tag="BSU_01040" /old_locus_tag="BSU01040" /label="rplJ gene" CDS 120198..120569 /gene="rplL" /locus_tag="BSU_01050" /old_locus_tag="BSU01050" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 6771249, 8755892, 26101249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 6771249, 8755892, 26101249; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L12 (BL9)" /protein_id="NP_387986.1" /db_xref="EnsemblGenomes-Gn:BSU01050" /db_xref="EnsemblGenomes-Tr:CAB11881" /db_xref="GOA:P02394" /db_xref="InterPro:IPR000206" /db_xref="InterPro:IPR008932" /db_xref="InterPro:IPR013823" /db_xref="InterPro:IPR014719" /db_xref="InterPro:IPR036235" /db_xref="SubtiList:BG10726" /db_xref="UniProtKB/Swiss-Prot:P02394" /translation="MALNIEEIIASVKEATVLELNDLVKAIEEEFGVTAAAPVAVAGG AAAGGAAEEQSEFDLILAGAGSQKIKVIKVVREITGLGLKEAKELVDNTPKPLKEGIA KEEAEELKAKLEEVGASVEVK*" /label="rplL CDS" gene 120198..120569 /gene="rplL" /locus_tag="BSU_01050" /old_locus_tag="BSU01050" /label="rplL gene" downshifts 120485 /Source="Nicolas_upshifts" /id="D44" /incds=1 /nref=5 /ntot=149 /MaxReadThrough="8.89506" /MaxDrop="4.0945" /score="20.6066659" /energy="-11.7" /TU="U88" /idTUdmin="U84" /TUdmin=2464 /isTUend="FALSE" /label="downshifts" downshifts 120558 /Source="Nicolas_upshifts" /id="D45" /incds=0 /nref=25 /ntot=157 /MaxReadThrough="7.44654" /MaxDrop="4.0033" /score="20.6066659" /energy="-11.7" /TU="U88" /idTUdmin="U84" /TUdmin=2537 /isTUend="FALSE" /label="downshifts" CDS 120659..121264 /gene="rlmG" /locus_tag="BSU_01060" /old_locus_tag="BSU01060" /EC_number="2.1.1.174" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17010380; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="23S rRNA m2G1835 methyltransferase" /protein_id="NP_387987.1" /db_xref="EnsemblGenomes-Gn:BSU01060" /db_xref="EnsemblGenomes-Tr:CAB11882" /db_xref="GOA:P37872" /db_xref="InterPro:IPR007848" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG10727" /db_xref="UniProtKB/Swiss-Prot:P37872" /translation="MSEHYYSEKPSVKSNKQTWSFRLRNKDFTFTSDSGVFSKKEVDF GSRLLIDSFEEPEVEGGILDVGCGYGPIGLSLASDFKDRTIHMIDVNERAVELSNENA EQNGITNVKIYQSDLFSNVDSAQTFASILTNPPIRAGKKVVHAIFEKSAEHLKASGEL WIVIQKKQGAPSAIEKLEELFDEVSVVQKKKGYYIIKAKKV*" /label="rlmG CDS" gene 120659..121264 /gene="rlmG" /locus_tag="BSU_01060" /old_locus_tag="BSU01060" /label="rlmG gene" promotor_-35 121259..121263 /Source="Nicolas_upshift_promotors" /id="U90" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.586413586413586" /psig="0.997002997002997" /xcortree=2493 /SigmaFactorBS="gttcaaaaaaagaaaggctattatatcataaaagcaaaaaaa GTTTGactcggtattttaacTATGTTAATATTGTAAAATGccaatgtatatattttgc t" /listShort="S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" S_feature 121277..121509 /Source="Nicolas_S_feature" /locus_tag="new_121686_121918" /HighExp="G180, G150, H2O2, G135, Cold, T-5.40H, LoTm, T-3.40H, Oxctl, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 1" /TUlongSig="SigA, SigK, SigA, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 0.999, 1, 1, 1, 0.947" /label="S51" upshifts 121277 /Source="Nicolas_upshifts" /id="U90" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.586413586413586" /psig="0.997002997002997" /xcortree=2493 /SigmaFactorBS="gttcaaaaaaagaaaggctattatatcataaaagcaaaaaaa GTTTGactcggtattttaacTATGTTAATATTGTAAAATGccaatgtatatattttgc t" /listShort="S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="upshifts" promotor_-10 121279..121298 /Source="Nicolas_upshift_promotors" /id="U90" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.586413586413586" /psig="0.997002997002997" /xcortree=2493 /SigmaFactorBS="gttcaaaaaaagaaaggctattatatcataaaagcaaaaaaa GTTTGactcggtattttaacTATGTTAATATTGTAAAATGccaatgtatatattttgc t" /listShort="S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" CDS 121510..125091 /gene="rpoB" /locus_tag="BSU_01070" /old_locus_tag="BSU01070" /EC_number="2.7.7.6" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10049799, 10744988, 12455702, 12682299, 15060052, 28163698" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10049799, 10744988, 12455702, 12682299, 15060052, 28163698; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="RNA polymerase (beta subunit)" /protein_id="NP_387988.2" /db_xref="EnsemblGenomes-Gn:BSU01070" /db_xref="EnsemblGenomes-Tr:CAB11883" /db_xref="GOA:P37870" /db_xref="InterPro:IPR007120" /db_xref="InterPro:IPR007121" /db_xref="InterPro:IPR007641" /db_xref="InterPro:IPR007642" /db_xref="InterPro:IPR007644" /db_xref="InterPro:IPR007645" /db_xref="InterPro:IPR010243" /db_xref="InterPro:IPR015712" /db_xref="InterPro:IPR019462" /db_xref="PDB:2LY7" /db_xref="SubtiList:BG10728" /db_xref="UniProtKB/Swiss-Prot:P37870" /translation="MTGQLVQYGRHRQRRSYARISEVLELPNLIEIQTSSYQWFLDEG LREMFQDISPIEDFTGNLSLEFIDYSLGEPKYPVEESKERDVTYSAPLRVKVRLINKE TGEVKDQDVFMGDFPIMTDTGTFIINGAERVIVSQLVRSPSVYFSGKVDKNGKKGFTA TVIPNRGAWLEYETDAKDVVYVRIDRTRKLPVTVLLRALGFGSDQEILDLIGENEYLR NTLDKDNTENSDKALLEIYERLRPGEPPTVENAKSLLDSRFFDPKRYDLANVGRYKIN KKLHIKNRLFNQRLAETLVDPETGEILAEKGQILDRRTLDKVLPYLENGIGFRKLYPN GGVVEDEVTLQSIKIFAPTDQEGEQVINVIGNAYIEEEIKNITPADIISSISYFFNLL HGVGDTDDIDHLGNRRLRSVGELLQNQFRIGLSRMERVVRERMSIQDTNTITPQQLIN IRPVIASIKEFFGSSQLSQFMDQTNPLAELTHKRRLSALGPGGLTRERAGMEVRDVHY SHYGRMCPIETPEGPNIGLINSLSSYAKVNRFGFIETPYRRVDPETGKVTGRIDYLTA DEEDNYVVAQANARLDDEGAFIDDSIVARFRGENTVVSRNRVDYMDVSPKQVVSAATA CIPFLENDDSNRALMGANMQRQAVPLMQPEAPFVGTGMEYVSGKDSGAAVICKHPGIV ERVEAKNVWVRRYEEVDGQKVKGNLDKYSLLKFVRSNQGTCYNQRPIVSVGDEVVKGE ILADGPSMELGELALGRNVMVGFMTWDGYNYEDAIIMSERLVKDDVYTSIHIEEYESE ARDTKLGPEEITRDIPNVGEDALRNLDDRGIIRIGAEVKDGDLLVGKVTPKGVTELTA EERLLHAIFGEKAREVRDTSLRVPHGGGGIIHDVKVFNREDGDELPPGVNQLVRVYIV QKRKISEGDKMAGRHGNKGVISKILPEEDMPYLPDGTPIDIMLNPLGVPSRMNIGQVL ELHMGMAARYLGIHIASPVFDGAREEDVWETLEEAGMSRDAKTVLYDGRTGEPFDNRV SVGIMYMIKLAHMVDDKLHARSTGPYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGA AYTLQEILTVKSDDVVGRVKTYEAIVKGDNVPEPGVPESFKVLIKELQSLGMDVKILS GDEEEIEMRDLEDEEDAKQADGLALSGDEEPEETASADVERDVVTKE*" /label="rpoB CDS" gene 121510..125091 /gene="rpoB" /locus_tag="BSU_01070" /old_locus_tag="BSU01070" /label="rpoB gene" promotor_-10 complement(123095..123114) /Source="Nicolas_upshift_promotors" /id="U91" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1252 /SigmaFactorBS="acgcggcgatatggcgtttcaATAAAGCCAAaacggtttact ttTGCATAAGATGATAGTGAGTtgatcaaaccgatgttcgggccctcaggcgtttcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(123098) /Source="Nicolas_upshifts" /id="U91" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1252 /SigmaFactorBS="acgcggcgatatggcgtttcaATAAAGCCAAaacggtttact ttTGCATAAGATGATAGTGAGTtgatcaaaccgatgttcgggccctcaggcgtttcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(123128..123137) /Source="Nicolas_upshift_promotors" /id="U91" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1252 /SigmaFactorBS="acgcggcgatatggcgtttcaATAAAGCCAAaacggtttact ttTGCATAAGATGATAGTGAGTtgatcaaaccgatgttcgggccctcaggcgtttcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(123966..123970) /Source="Nicolas_upshift_promotors" /id="U92" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig=0 /xcortree=63 /SigmaFactorBS="agatctccgtcttttacttctgccccaatacggatgattcCG CGGTCatcaagattgcgaaGCGCAtcttcaccgacgtttggaatatcgcgagtgattt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(123971) /Source="Nicolas_upshifts" /id="U92" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig=0 /xcortree=63 /SigmaFactorBS="agatctccgtcttttacttctgccccaatacggatgattcCG CGGTCatcaagattgcgaaGCGCAtcttcaccgacgtttggaatatcgcgagtgattt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(123985..123991) /Source="Nicolas_upshift_promotors" /id="U92" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig=0 /xcortree=63 /SigmaFactorBS="agatctccgtcttttacttctgccccaatacggatgattcCG CGGTCatcaagattgcgaaGCGCAtcttcaccgacgtttggaatatcgcgagtgattt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 125153..128752 /gene="rpoC" /locus_tag="BSU_01080" /old_locus_tag="BSU01080" /EC_number="2.7.7.6" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10672039, 10675340, 10910724, 11029421, 9795209, 10438769, 23070162, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10672039, 10675340, 10910724, 11029421, 9795209, 10438769, 23070162, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="RNA polymerase (beta' subunit)" /protein_id="NP_387989.2" /db_xref="EnsemblGenomes-Gn:BSU01080" /db_xref="EnsemblGenomes-Tr:CAB11884" /db_xref="GOA:P37871" /db_xref="InterPro:IPR000722" /db_xref="InterPro:IPR006592" /db_xref="InterPro:IPR007066" /db_xref="InterPro:IPR007080" /db_xref="InterPro:IPR007081" /db_xref="InterPro:IPR007083" /db_xref="InterPro:IPR012754" /db_xref="SubtiList:BG10729" /db_xref="UniProtKB/Swiss-Prot:P37871" /translation="MLDVNNFEYMNIGLASPDKIRSWSFGEVKKPETINYRTLKPEKD GLFCERIFGPTKDWECHCGKYKRVRYKGVVCDRCGVEVTRAKVRRERMGHIELAAPVS HIWYFKGIPSRMGLVLDMSPRALEEVIYFASYVVTDPANTPLEKKQLLSEKEYRAYLD KYGNKFQASMGAEAIHKLLQDIDLVKEVDMLKEELKTSQGQRRTRAIKRLEVLEAFRN SGNKPSWMILDVLPVIPPELRPMVQLDGGRFATSDLNDLYRRVINRNNRLKRLLDLGA PSIIVQNEKRMLQEAVDALIDNGRRGRPVTGPGNRPLKSLSHMLKGKQGRFRQNLLGK RVDYSGRSVIVVGPHLKMYQCGLPKEMALELFKPFVMKELVEKGLAHNIKSAKRKIER VQPEVWDVLESVIKEHPVLLNRAPTLHRLGIQAFEPTLVEGRAIRLHPLVCTAYNADF DGDQMAVHVPLSAEAQAEARILMLAAQNILNPKDGKPVVTPSQDMVLGNYYLTLERAG AVGEGMVFKNTDEALLAYQNGYVHLHTRVAVAANSLKNVTFTEEQRSKLLITTVGKLV FNEILPESFPYMNEPTKSNIEEKTPDRFFLEKGADVKAVIAQQPINAPFKKGILGKII AEIFKRFHITETSKMLDRMKNLGFKYSTKAGITVGVSDIVVLDDKQEILEEAQSKVDN VMKQFRRGLITEEERYERVISIWSAAKDVIQGKLMKSLDELNPIYMMSDSGARGNASN FTQLAGMRGLMANPAGRIIELPIKSSFREGLTVLEYFISTHGARKGLADTALKTADSG YLTRRLVDVAQDVIIRETDCGTDRGILAKPLKEGTETIERLEERLIGRFARKQVKHPE TGEVLVNENELIDEDKALEIVEAGIEEVWIRSAFTCNTPHGVCKRCYGRNLATGSDVE VGEAVGIIAAQSIGEPGTQLTMRTFHTGGVAGDDITQGLPRIQELFEARNPKGQATIT EIDGTVVEINEVRDKQQEIVVQGAVETRSYTAPYNSRLKVAEGDKITRGQVLTEGSID PKELLKVTDLTTVQEYLLHEVQKVYRMQGVEIGDKHVEVMVRQMLRKVRVIDAGDTDV LPGTLLDIHQFTEANKKVLLEGNRPATGRPVLLGITKASLETDSFLSAASFQETTRVL TDAAIKGKRDELLGLKENVIIGKLVPAGTGMMKYRKVKPVSNVQPTDDMVPVE*" /label="rpoC CDS" gene 125153..128752 /gene="rpoC" /locus_tag="BSU_01080" /old_locus_tag="BSU01080" /label="rpoC gene" downshifts complement(128217) /Source="Nicolas_upshifts" /id="D46" /incds=1 /nref=1 /ntot=76 /MaxReadThrough="3.40002" /MaxDrop="2.38911" /score="-2.05539956" /energy="-7.5" /TU="U93" /idTUdmin="U93" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" upshifts complement(128371) /Source="Nicolas_upshifts" /id="U93" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.952047952047952" /psig="0.000999000999001" /xcortree=64 /SigmaFactorBS="caatgtacctggaagcacatcagtgtcaccggcatcaatcaC Gcgtactttgcgaagcatctggcgaaccattacttctacgtgtttatcaccgatttca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(128389..128390) /Source="Nicolas_upshift_promotors" /id="U93" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.952047952047952" /psig="0.000999000999001" /xcortree=64 /SigmaFactorBS="caatgtacctggaagcacatcagtgtcaccggcatcaatcaC Gcgtactttgcgaagcatctggcgaaccattacttctacgtgtttatcaccgatttca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" downshifts complement(128701) /Source="Nicolas_upshifts" /id="D47" /incds=0 /nref=98 /ntot=210 /MaxReadThrough="1.61828" /MaxDrop="4.90549" /score="-2.05539956" /energy="-7.5" /TU="NA" /idTUdmin="U95" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 128753..128874 /Source="Nicolas_S_feature" /locus_tag="new_129162_129283" /HighExp="LoTm, HiOs, S3, SMMPr, Heat, S1, BC, Glu, S4, MG 45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 1" /TUlongSig="SigA, SigK, SigA, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 0.999, 1, 1, 1, 0.947" /label="S52" promotor_-35 128856..128863 /Source="Nicolas_upshift_promotors" /id="U94" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.781218781218781" /psig=1 /xcortree=2650 /SigmaFactorBS="cactctatgagaagaacgaatctaaaaaatgtcataccttGT TGACATtcgtctcctagaaTGATAATATAACCAAGGTGCtcgaaataaacctgttact t" /listShort="rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" upshifts 128876 /Source="Nicolas_upshifts" /id="U94" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.781218781218781" /psig=1 /xcortree=2650 /SigmaFactorBS="cactctatgagaagaacgaatctaaaaaatgtcataccttGT TGACATtcgtctcctagaaTGATAATATAACCAAGGTGCtcgaaataaacctgttact t" /listShort="rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="upshifts" promotor_-10 128877..128896 /Source="Nicolas_upshift_promotors" /id="U94" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.781218781218781" /psig=1 /xcortree=2650 /SigmaFactorBS="cactctatgagaagaacgaatctaaaaaatgtcataccttGT TGACATtcgtctcctagaaTGATAATATAACCAAGGTGCtcgaaataaacctgttact t" /listShort="rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" misc_feature complement(128894..128898) /Source="Nicolas_upshift_promotors" /id="U95" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.909090909090909" /psig="0.023976023976024" /xcortree=67 /SigmaFactorBS="ggcctgtgatactttatcataagacataaacatatcctccaa agtaacaggtttatttcGAGCAccttggttatattatcattctaggagacgaatgtca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(128897) /Source="Nicolas_upshifts" /id="U95" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.909090909090909" /psig="0.023976023976024" /xcortree=67 /SigmaFactorBS="ggcctgtgatactttatcataagacataaacatatcctccaa agtaacaggtttatttcGAGCAccttggttatattatcattctaggagacgaatgtca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 128931..129179 /gene="rulS" /locus_tag="BSU_01090" /old_locus_tag="BSU01090" /function="16.8: Protect" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11574053, 11948165, 17468242, 7657605, 22355167, 23249744, 24204571, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11574053, 11948165, 17468242, 7657605, 22355167, 23249744, 24204571, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="K-turn RNA binding protein; alternative ribosomal protein L7A" /protein_id="NP_387990.1" /db_xref="EnsemblGenomes-Gn:BSU01090" /db_xref="EnsemblGenomes-Tr:CAB11885" /db_xref="GOA:P46350" /db_xref="InterPro:IPR000948" /db_xref="InterPro:IPR004038" /db_xref="InterPro:IPR023460" /db_xref="InterPro:IPR029064" /db_xref="PDB:3V7E" /db_xref="PDB:4LCK" /db_xref="PDB:4TZP" /db_xref="PDB:4TZV" /db_xref="PDB:4TZW" /db_xref="PDB:4TZZ" /db_xref="SubtiList:BG11365" /db_xref="UniProtKB/Swiss-Prot:P46350" /translation="MSYDKVSQAKSIIIGTKQTVKALKRGSVKEVVVAKDADPILTSS VVSLAEDQGISVSMVESMKKLGKACGIEVGAAAVAIIL*" /label="rulS CDS" gene 128931..129179 /gene="rulS" /locus_tag="BSU_01090" /old_locus_tag="BSU01090" /label="rulS gene" S_feature 129180..129292 /Source="Nicolas_S_feature" /locus_tag="new_129589_129701" /HighExp="T-3.40H, M/G, T-1.40H, T-5.40H, Salt, Mal, T-0.40H, G/S, M9-exp, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 0.997, 1" /TUlongSig="SigA, SigK, SigA, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 0.999, 1, 1, 1, 0.947" /label="S53" CDS 129293..129709 /gene="rpsL" /locus_tag="BSU_01100" /old_locus_tag="BSU01100" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11489846, 12682299, 16484214, 18252828, 19383706, 20007320" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11489846, 12682299, 16484214, 18252828, 19383706, 20007320; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S12 (BS12)" /protein_id="NP_387991.2" /db_xref="EnsemblGenomes-Gn:BSU01100" /db_xref="EnsemblGenomes-Tr:CAB11886" /db_xref="GOA:P21472" /db_xref="InterPro:IPR005679" /db_xref="InterPro:IPR006032" /db_xref="InterPro:IPR012340" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19009" /db_xref="UniProtKB/Swiss-Prot:P21472" /translation="MPTINQLIRKGRVSKVENSKSPALNKGYNSFKKEHTNVSSPQKR GVCTRVGTMTPKKPNSALRKYARVRLTNGIEVTAYIPGIGHNLQEHSVVLIRGGRVKD LPGVRYHIVRGALDTAGVENRAQGRSKYGTKKPKAK*" /label="rpsL CDS" gene 129293..129709 /gene="rpsL" /locus_tag="BSU_01100" /old_locus_tag="BSU01100" /label="rpsL gene" CDS 129751..130221 /gene="rpsG" /locus_tag="BSU_01110" /old_locus_tag="BSU01110" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8722036, 12682299, 19653700" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8722036, 12682299, 19653700; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S7 (BS7)" /protein_id="NP_387992.2" /db_xref="EnsemblGenomes-Gn:BSU01110" /db_xref="EnsemblGenomes-Tr:CAB11887" /db_xref="GOA:P21469" /db_xref="InterPro:IPR000235" /db_xref="InterPro:IPR005717" /db_xref="InterPro:IPR020606" /db_xref="InterPro:IPR023798" /db_xref="InterPro:IPR036823" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19006" /db_xref="UniProtKB/Swiss-Prot:P21469" /translation="MPRKGPVAKRDVLPDPIYNSKLVSRLINKMMIDGKKGKSQTILY KSFDIIKERTGNDAMEVFEQALKNIMPVLEVKARRVGGANYQVPVEVRPERRTTLGLR WLVNYARLRGEKTMEERLANEILDAANNTGAAVKKREDTHKMAEANKAFAHYRW*" /label="rpsG CDS" gene 129751..130221 /gene="rpsG" /locus_tag="BSU_01110" /old_locus_tag="BSU01110" /label="rpsG gene" CDS 130275..132353 /gene="fusA" /locus_tag="BSU_01120" /old_locus_tag="BSU01120" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:815236, 815243, 1556067, 4629789, 19366171, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 815236, 815243, 1556067, 4629789, 19366171, 22720735; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="elongation factor G" /protein_id="NP_387993.2" /db_xref="EnsemblGenomes-Gn:BSU01120" /db_xref="EnsemblGenomes-Tr:CAB11888" /db_xref="GOA:P80868" /db_xref="InterPro:IPR000640" /db_xref="InterPro:IPR000795" /db_xref="InterPro:IPR004161" /db_xref="InterPro:IPR004540" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR005517" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR009022" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031157" /db_xref="InterPro:IPR035647" /db_xref="InterPro:IPR035649" /db_xref="PDB:5VH6" /db_xref="SubtiList:BG11939" /db_xref="UniProtKB/Swiss-Prot:P80868" /translation="MAREFSLEKTRNIGIMAHIDAGKTTTTERILFYTGRIHKIGETH EGASQMDWMEQEQERGITITSAATTAQWKGYRVNIIDTPGHVDFTVEVERSLRVLDGA VAVLDAQSGVEPQTETVWRQATTYGVPRIVFVNKMDKIGADFLYSVGTLRDRLQANAH AIQLPIGAEDNFEGIIDLVENVAYFYEDDLGTRSDAKEIPEEYKEQAEELRNSLIEAV CELDEELMDKYLEGEEITIDELKAGIRKGTLNVEFYPVLVGSAFKNKGVQLVLDAVLD YLPAPTDVAAIKGTRPDTNEEIERHSSDEEPFSALAFKVMTDPYVGKLTFFRVYSGTL DSGSYVKNSTKGKRERVGRILQMHANSREEISTVYAGDIAAAVGLKDTTTGDTLCDEK DLVILESMEFPEPVIDVAIEPKSKADQDKMGIALAKLAEEDPTFRTQTNPETGQTIIS GMGELHLDIIVDRMKREFKVEANVGAPQVAYRETFRTGAKVEGKFVRQSGGRGQFGHV WIEFEPNEEGAGFEFENAIVGGVVPREYIPAVQAGLEDALENGVLAGFPLIDIKAKLF DGSYHDVDSNEMAFKVAASMALKNAVSKCNPVLLEPIMKVEVVIPEEYMGDIMGDITS RRGRVEGMEARGNAQVVRAMVPLAEMFGYATALRSNTQGRGTFTMHMDHYEEVPKSVA EEIIKKNKGE*" /label="fusA CDS" gene 130275..132353 /gene="fusA" /locus_tag="BSU_01120" /old_locus_tag="BSU01120" /label="fusA gene" S_feature 132354..132472 /Source="Nicolas_S_feature" /locus_tag="new_132763_132881" /HighExp="T-5.40H, T-4.40H, UNK1, SMM, HiTm, T-3.40H, T-2.40H, SMMPr, MG 90, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 0.997, 1" /TUlongSig="SigA, SigK, SigA, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 0.999, 1, 1, 1, 0.947" /label="S54" CDS 132473..133663 /gene="tufA" /locus_tag="BSU_01130" /old_locus_tag="BSU01130" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10774755, 12682299, 7706132, 20133608, 22938038, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10774755, 12682299, 7706132, 20133608, 22938038, 22720735; Product type f : factor" /codon_start=1 /transl_table=11 /product="elongation factor Tu" /protein_id="NP_387994.1" /db_xref="EnsemblGenomes-Gn:BSU01130" /db_xref="EnsemblGenomes-Tr:CAB11889" /db_xref="GOA:P33166" /db_xref="InterPro:IPR000795" /db_xref="InterPro:IPR004160" /db_xref="InterPro:IPR004161" /db_xref="InterPro:IPR004541" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR009001" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031157" /db_xref="InterPro:IPR033720" /db_xref="SubtiList:BG11056" /db_xref="UniProtKB/Swiss-Prot:P33166" /translation="MAKEKFDRSKSHANIGTIGHVDHGKTTLTAAITTVLHKKSGKGT AMAYDQIDGAPEERERGITISTAHVEYETETRHYAHVDCPGHADYVKNMITGAAQMDG AILVVSAADGPMPQTREHILLSKNVGVPYIVVFLNKCDMVDDEELLELVEMEVRDLLS EYDFPGDDVPVVKGSALKALEGDAEWEAKIFELMDAVDEYIPTPERDTEKPFMMPVED VFSITGRGTVATGRVERGQVKVGDEVEIIGLQEENKKTTVTGVEMFRKLLDYAEAGDN IGALLRGVSREEIQRGQVLAKPGTITPHSKFKAEVYVLSKEEGGRHTPFFSNYRPQFY FRTTDVTGIIHLPEGVEMVMPGDNTEMNVELISTIAIEEGTRFSIREGGRTVGSGVVS TITE*" /label="tufA CDS" gene 132473..133663 /gene="tufA" /locus_tag="BSU_01130" /old_locus_tag="BSU01130" /label="tufA gene" downshifts 133658 /Source="Nicolas_upshifts" /id="D48" /incds=0 /nref=258 /ntot=269 /MaxReadThrough="4.84568" /MaxDrop="8.56168" /score="39.3984056" /energy="-12.9" /TU="U88,U90,U94" /idTUdmin="U88" /TUdmin="-1081" /isTUend="FALSE" /label="downshifts" misc_feature complement(133689..133692) /Source="Nicolas_upshift_promotors" /id="U96" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.917082917082917" /psig="0.001998001998002" /xcortree=68 /SigmaFactorBS="acccctcgaatatgatagatcctattatacaagaaaaagata agcaaacaaaaaacgagacCCACaggggtctcgtttaaaaccatactattactcagtg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(133693) /Source="Nicolas_upshifts" /id="U96" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.917082917082917" /psig="0.001998001998002" /xcortree=68 /SigmaFactorBS="acccctcgaatatgatagatcctattatacaagaaaaagata agcaaacaaaaaacgagacCCACaggggtctcgtttaaaaccatactattactcagtg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 133719..133738 /Source="Nicolas_upshift_promotors" /id="U97" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=1878 /SigmaFactorBS="tatggttttaaacgagacccctgtgggtctcgttttttgttt gcttatctttTTCTTGTATAATAGGATCTAtcatattcgaggggttaatatttatgat t" /listShort="ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 133727 /Source="Nicolas_upshifts" /id="U97" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=1878 /SigmaFactorBS="tatggttttaaacgagacccctgtgggtctcgttttttgttt gcttatctttTTCTTGTATAATAGGATCTAtcatattcgaggggttaatatttatgat t" /listShort="ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="upshifts" CDS 133762..134718 /gene="ybaC" /locus_tag="BSU_01140" /old_locus_tag="BSU01140" /EC_number="3.4.11.5" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative proline iminopeptidase" /protein_id="NP_387995.2" /db_xref="EnsemblGenomes-Gn:BSU01140" /db_xref="EnsemblGenomes-Tr:CAB11890" /db_xref="GOA:P70981" /db_xref="InterPro:IPR002410" /db_xref="InterPro:IPR022742" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG11988" /db_xref="UniProtKB/Swiss-Prot:P70981" /translation="MIPEKKSIAIMKELSIGNTKQMLMINGVDVKNPLLLFLHGGPGT PQIGYVRHYQKELEQYFTVVHWDQRGSGLSYSKRISHHSMTINHFIKDTIQVTQWLLA HFSKSKLYLAGHSWGSILALHVLQQRPDLFYTYYGISQVVNPQDEESTAYQHIREISE SKKASILSFLTRFIGAPPWKQDIQHLIYRFCVELTRGGFTHRHRQSLAVLFQMLTGNE YGVRNMHSFLNGLRFSKKHLTDELYRFNAFTSVPSIKVPCVFISGKHDLIVPAEISKQ YYQELEAPEKRWFQFENSAHTPHIEEPSLFANTLSRHARHHL*" /label="ybaC CDS" gene 133762..134718 /gene="ybaC" /locus_tag="BSU_01140" /old_locus_tag="BSU01140" /label="ybaC gene" promotor_-35 134725..134732 /Source="Nicolas_upshift_promotors" /id="U98" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=2656 /SigmaFactorBS="gcacgacaccatttatgatagatcCTTGATAAataagaaaaa cccCTGTATAATAAAAAAAGTGTgcaaatcatgcatattttaaataagtcttgcaaca t" /listShort="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 134746..134765 /Source="Nicolas_upshift_promotors" /id="U98" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=2656 /SigmaFactorBS="gcacgacaccatttatgatagatcCTTGATAAataagaaaaa cccCTGTATAATAAAAAAAGTGTgcaaatcatgcatattttaaataagtcttgcaaca t" /listShort="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 134761..134954 /Source="Nicolas_S_feature" /locus_tag="new_135170_135363" /HighExp="T-1.40H, T-2.40H, T-1.10H, SMM, T-3.40H, T-4.40H, BI, BMM, H2O2, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA, SigA, SigA, SigA, SigA, SigWXY, SigA, SigA" /TUlongPSig="1, 1, 0.997, 1, 1, 0.999, 1, 1, 0.947" /label="S55" upshifts 134761 /Source="Nicolas_upshifts" /id="U98" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=2656 /SigmaFactorBS="gcacgacaccatttatgatagatcCTTGATAAataagaaaaa cccCTGTATAATAAAAAAAGTGTgcaaatcatgcatattttaaataagtcttgcaaca t" /listShort="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="upshifts" CDS 134955..135263 /gene="rpsJ" /locus_tag="BSU_01150" /old_locus_tag="BSU01150" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 27964882" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 27964882; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S10 (BS13); transcription antitermination factor" /protein_id="NP_387996.1" /db_xref="EnsemblGenomes-Gn:BSU01150" /db_xref="EnsemblGenomes-Tr:CAB11891" /db_xref="GOA:P21471" /db_xref="InterPro:IPR001848" /db_xref="InterPro:IPR018268" /db_xref="InterPro:IPR027486" /db_xref="InterPro:IPR036838" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19008" /db_xref="UniProtKB/Swiss-Prot:P21471" /translation="MAKQKIRIRLKAYDHRILDQSAEKIVETAKRSGASVSGPIPLPT EKSVYTILRAVHKYKDSREQFEMRTHKRLIDIVNPTPQTVDALMRLDLPSGVDIEIKL *" /label="rpsJ CDS" gene 134955..135263 /gene="rpsJ" /locus_tag="BSU_01150" /old_locus_tag="BSU01150" /label="rpsJ gene" CDS 135303..135932 /gene="rplC" /locus_tag="BSU_01160" /old_locus_tag="BSU01160" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 17981968, 19154332, 23759864" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17981968, 19154332, 23759864; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L3 (BL3)" /protein_id="NP_387997.1" /db_xref="EnsemblGenomes-Gn:BSU01160" /db_xref="EnsemblGenomes-Tr:CAB11892" /db_xref="GOA:P42920" /db_xref="InterPro:IPR000597" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR019926" /db_xref="InterPro:IPR019927" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11218" /db_xref="UniProtKB/Swiss-Prot:P42920" /translation="MTKGILGRKIGMTQVFAENGDLIPVTVIEAAPNVVLQKKTAEND GYEAIQLGFDDKREKLSNKPEKGHVAKAETAPKRFVKELRGVEMDAYEVGQEVKVEIF SAGEIVDVTGVSKGKGFQGAIKRHGQSRGPMSHGSRYHRRPGSMGPVDPNRVFKGKLL PGRMGGEQITVQNLEIVKVDAERNLLLIKGNVPGAKKSLITVKSAVKSK*" /label="rplC CDS" gene 135303..135932 /gene="rplC" /locus_tag="BSU_01160" /old_locus_tag="BSU01160" /label="rplC gene" CDS 135960..136583 /gene="rplD" /locus_tag="BSU_01170" /old_locus_tag="BSU01170" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10898684, 12682299, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L4" /protein_id="NP_387998.1" /db_xref="EnsemblGenomes-Gn:BSU01170" /db_xref="EnsemblGenomes-Tr:CAB11893" /db_xref="GOA:P42921" /db_xref="InterPro:IPR002136" /db_xref="InterPro:IPR013005" /db_xref="InterPro:IPR023574" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11219" /db_xref="UniProtKB/Swiss-Prot:P42921" /translation="MPKVALYNQNGSTAGDIELNASVFGIEPNESVVFDAILMQRASL RQGTHKVKNRSEVRGGGRKPWRQKGTGRARQGSIRSPQWRGGGVVFGPTPRSYSYKLP KKVRRLAIKSVLSSKVIDNNIIVLEDLTLDTAKTKEMAAILKGLSVEKKALIVTADAN EAVALSARNIPGVTVVEANGINVLDVVNHEKLLITKAAVEKVEEVLA*" /label="rplD CDS" gene 135960..136583 /gene="rplD" /locus_tag="BSU_01170" /old_locus_tag="BSU01170" /label="rplD gene" CDS 136583..136870 /gene="rplW" /locus_tag="BSU_01180" /old_locus_tag="BSU01180" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 17981968, 23002217" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17981968, 23002217; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L23" /protein_id="NP_387999.2" /db_xref="EnsemblGenomes-Gn:BSU01180" /db_xref="EnsemblGenomes-Tr:CAB11894" /db_xref="GOA:P42924" /db_xref="InterPro:IPR001014" /db_xref="InterPro:IPR012678" /db_xref="InterPro:IPR013025" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11221" /db_xref="UniProtKB/Swiss-Prot:P42924" /translation="MKDPRDVLKRPVITERSADLMTEKKYTFEVDVRANKTEVKDAVE SIFGVKVDKVNIMNYKGKSKRVGRYTGMTSRRRKAIVKLTADSKEIEIFEA*" /label="rplW CDS" gene 136583..136870 /gene="rplW" /locus_tag="BSU_01180" /old_locus_tag="BSU01180" /label="rplW gene" CDS 136902..137735 /gene="rplB" /locus_tag="BSU_01190" /old_locus_tag="BSU01190" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 23249812, 24637032" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 23249812, 24637032; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L2 (BL2)" /protein_id="NP_388000.2" /db_xref="EnsemblGenomes-Gn:BSU01190" /db_xref="EnsemblGenomes-Tr:CAB11895" /db_xref="GOA:P42919" /db_xref="InterPro:IPR002171" /db_xref="InterPro:IPR005880" /db_xref="InterPro:IPR008991" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR014722" /db_xref="InterPro:IPR014726" /db_xref="InterPro:IPR022666" /db_xref="InterPro:IPR022669" /db_xref="InterPro:IPR022671" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11217" /db_xref="UniProtKB/Swiss-Prot:P42919" /translation="MAIKKYKPTSNGRRGMTTSDFAEITTDKPEKSLLAPLHKKGGRN NQGKLTVRHQGGGHKRQYRVIDFKRDKDGIPGRVATVEYDPNRSANIALINYADGEKR YILAPKGIQVGTEIMSGPEADIKVGNALPLINIPVGTVVHNIELKPGKGGQLVRSAGT SAQVLGKEGKYVLVRLNSGEVRMILSACRASIGQVGNEQHELINIGKAGRSRWKGIRP TVRGSVMNPNDHPHGGGEGRAPIGRKSPMSPWGKPTLGFKTRKKKNKSDKFIVRRRKN K*" /label="rplB CDS" gene 136902..137735 /gene="rplB" /locus_tag="BSU_01190" /old_locus_tag="BSU01190" /label="rplB gene" downshifts complement(137038) /Source="Nicolas_upshifts" /id="D49" /incds=1 /nref=1 /ntot=47 /MaxReadThrough="3.39972" /MaxDrop="4.09052" /score="-4.16840603" /energy="-12.8" /TU="NA" /idTUdmin="U99" /TUdmin=1342 /isTUend="FALSE" /label="downshifts" CDS 137793..138071 /gene="rpsS" /locus_tag="BSU_01200" /old_locus_tag="BSU01200" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S19 (BS19)" /protein_id="NP_388001.1" /db_xref="EnsemblGenomes-Gn:BSU01200" /db_xref="EnsemblGenomes-Tr:CAB11896" /db_xref="GOA:P21476" /db_xref="InterPro:IPR002222" /db_xref="InterPro:IPR005732" /db_xref="InterPro:IPR020934" /db_xref="InterPro:IPR023575" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19011" /db_xref="UniProtKB/Swiss-Prot:P21476" /translation="MARSLKKGPFVDGHLMTKIEKLNETDKKQVVKTWSRRSTIFPQF IGHTIAVYDGRKHVPVFISEDMVGHKLGEFAPTRTYKGHASDDKKTRR*" /label="rpsS CDS" gene 137793..138071 /gene="rpsS" /locus_tag="BSU_01200" /old_locus_tag="BSU01200" /label="rpsS gene" CDS 138088..138429 /gene="rplV" /locus_tag="BSU_01210" /old_locus_tag="BSU01210" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7928988, 12682299, 23002217" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7928988, 12682299, 23002217; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L22 (BL17)" /protein_id="NP_388002.1" /db_xref="EnsemblGenomes-Gn:BSU01210" /db_xref="EnsemblGenomes-Tr:CAB11897" /db_xref="GOA:P42060" /db_xref="InterPro:IPR001063" /db_xref="InterPro:IPR005727" /db_xref="InterPro:IPR018260" /db_xref="InterPro:IPR036394" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11078" /db_xref="UniProtKB/Swiss-Prot:P42060" /translation="MQAKAVARTVRIAPRKARLVMDLIRGKQVGEAVSILNLTPRAAS PIIEKVLKSAIANAEHNYEMDANNLVISQAFVDEGPTLKRFRPRAMGRASQINKRTSH ITIVVSEKKEG*" /label="rplV CDS" gene 138088..138429 /gene="rplV" /locus_tag="BSU_01210" /old_locus_tag="BSU01210" /label="rplV gene" CDS 138433..139089 /gene="rpsC" /locus_tag="BSU_01220" /old_locus_tag="BSU01220" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S3 (BS3)" /protein_id="NP_388003.2" /db_xref="EnsemblGenomes-Gn:BSU01220" /db_xref="EnsemblGenomes-Tr:CAB11898" /db_xref="GOA:P21465" /db_xref="InterPro:IPR001351" /db_xref="InterPro:IPR004044" /db_xref="InterPro:IPR004087" /db_xref="InterPro:IPR005704" /db_xref="InterPro:IPR009019" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR018280" /db_xref="InterPro:IPR036419" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19005" /db_xref="UniProtKB/Swiss-Prot:P21465" /translation="MGQKVNPVGLRIGVIRDWESKWYAGKDYADFLHEDLKIREYISK RLSDASVSKVEIERAANRVNITIHTAKPGMVIGKGGSEVEALRKALNSLTGKRVHINI LEIKRADLDAQLVADNIARQLENRVSFRRAQKQQIQRTMRAGAQGVKTMVSGRLGGAD IARSEYYSEGTVPLHTLRADIDYATSEADTTYGKLGVKVWIYRGEVLPTKKKNEEGGK *" /label="rpsC CDS" gene 138433..139089 /gene="rpsC" /locus_tag="BSU_01220" /old_locus_tag="BSU01220" /label="rpsC gene" downshifts complement(138446) /Source="Nicolas_upshifts" /id="D50" /incds=0 /nref=1 /ntot=62 /MaxReadThrough="3.68388" /MaxDrop="2.1922" /score="-4.16840603" /energy="-12.8" /TU="U99" /idTUdmin="U99" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(138527..138531) /Source="Nicolas_upshift_promotors" /id="U99" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.972027972027972" /psig="0.00999000999001" /xcortree=77 /SigmaFactorBS="tactttagaaacagaagcgtcagaaaggcgtttgctaatgta ttCACgaatttttaaatcttcGTGCAggaagtcagcgtaatctttaccagcgtaccac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(138534) /Source="Nicolas_upshifts" /id="U99" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.972027972027972" /psig="0.00999000999001" /xcortree=77 /SigmaFactorBS="tactttagaaacagaagcgtcagaaaggcgtttgctaatgta ttCACgaatttttaaatcttcGTGCAggaagtcagcgtaatctttaccagcgtaccac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(138548..138550) /Source="Nicolas_upshift_promotors" /id="U99" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.972027972027972" /psig="0.00999000999001" /xcortree=77 /SigmaFactorBS="tactttagaaacagaagcgtcagaaaggcgtttgctaatgta ttCACgaatttttaaatcttcGTGCAggaagtcagcgtaatctttaccagcgtaccac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 139091..139525 /gene="rplP" /locus_tag="BSU_01230" /old_locus_tag="BSU01230" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 16390447, 24335279" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16390447, 24335279; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L16" /protein_id="NP_388004.1" /db_xref="EnsemblGenomes-Gn:BSU01230" /db_xref="EnsemblGenomes-Tr:CAB11899" /db_xref="GOA:P14577" /db_xref="InterPro:IPR000114" /db_xref="InterPro:IPR016180" /db_xref="InterPro:IPR020798" /db_xref="InterPro:IPR036920" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10755" /db_xref="UniProtKB/Swiss-Prot:P14577" /translation="MLLPKRVKYRREHRGKMRGRAKGGTEVHFGEFGIQALEASWITN RQIEAARIAMTRYMKRGGKVWIKIFPSKPYTAKPLEVRMGSGKGAPEGWVAVVKPGKV LFEISGVSEEVAREALRLASHKLPIKTKFVKREEIGGESNES*" /label="rplP CDS" gene 139091..139525 /gene="rplP" /locus_tag="BSU_01230" /old_locus_tag="BSU01230" /label="rplP gene" CDS 139515..139715 /gene="rpmC" /locus_tag="BSU_01240" /old_locus_tag="BSU01240" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 23002217" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 23002217; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L29" /protein_id="NP_388005.1" /db_xref="EnsemblGenomes-Gn:BSU01240" /db_xref="EnsemblGenomes-Tr:CAB11900" /db_xref="GOA:P12873" /db_xref="InterPro:IPR001854" /db_xref="InterPro:IPR018254" /db_xref="InterPro:IPR036049" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10756" /db_xref="UniProtKB/Swiss-Prot:P12873" /translation="MKANEIRDLTTAEIEQKVKSLKEELFNLRFQLATGQLENTARIR EVRKAIARMKTVIREREIAANK*" /label="rpmC CDS" gene 139515..139715 /gene="rpmC" /locus_tag="BSU_01240" /old_locus_tag="BSU01240" /label="rpmC gene" CDS 139738..140001 /gene="rpsQ" /locus_tag="BSU_01250" /old_locus_tag="BSU01250" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S17 (BS16)" /protein_id="NP_388006.1" /db_xref="EnsemblGenomes-Gn:BSU01250" /db_xref="EnsemblGenomes-Tr:CAB11901" /db_xref="GOA:P12874" /db_xref="InterPro:IPR000266" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR019979" /db_xref="InterPro:IPR019984" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10757" /db_xref="UniProtKB/Swiss-Prot:P12874" /translation="MSERNQRKVYQGRVVSDKMDKTITVVVETYKKHTLYGKRVKYSK KFKAHDENNQAKIGDIVKIMETRPLSATKRFRLVEVVEEAVII*" /label="rpsQ CDS" gene 139738..140001 /gene="rpsQ" /locus_tag="BSU_01250" /old_locus_tag="BSU01250" /label="rpsQ gene" CDS 140042..140410 /gene="rplNA" /locus_tag="BSU_01260" /old_locus_tag="BSU01260" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8722036, 8805509, 12682299, 22829778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8722036, 8805509, 12682299, 22829778; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L14" /protein_id="NP_388007.1" /db_xref="EnsemblGenomes-Gn:BSU01260" /db_xref="EnsemblGenomes-Tr:CAB11902" /db_xref="GOA:P12875" /db_xref="InterPro:IPR000218" /db_xref="InterPro:IPR005745" /db_xref="InterPro:IPR019972" /db_xref="InterPro:IPR036853" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10758" /db_xref="UniProtKB/Swiss-Prot:P12875" /translation="MIQQETRLKVADNSGAREVLTIKVLGGSGRKTANIGDVIVCTVK QATPGGVVKKGEVVKAVIVRTKSGARRSDGSYISFDENACVIIRDDKSPRGTRIFGPV ARELRENNFMKIVSLAPEVI*" /label="rplNA CDS" gene 140042..140410 /gene="rplNA" /locus_tag="BSU_01260" /old_locus_tag="BSU01260" /label="rplNA gene" CDS 140448..140759 /gene="rplX" /locus_tag="BSU_01270" /old_locus_tag="BSU01270" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11278078, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11278078, 12682299; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L24 (BL23)" /protein_id="NP_388008.1" /db_xref="EnsemblGenomes-Gn:BSU01270" /db_xref="EnsemblGenomes-Tr:CAB11903" /db_xref="GOA:P0CI78" /db_xref="InterPro:IPR003256" /db_xref="InterPro:IPR005824" /db_xref="InterPro:IPR005825" /db_xref="InterPro:IPR008991" /db_xref="InterPro:IPR014722" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10759" /db_xref="UniProtKB/Swiss-Prot:P0CI78" /translation="MHVKKGDKVMVISGKDKGKQGTILAAFPKKDRVLVEGVNMVKKH SKPTQANPQGGISNQEAPIHVSNVMPLDPKTGEVTRVGYKVEDGKKVRVAKKSGQVLD K*" /label="rplX CDS" gene 140448..140759 /gene="rplX" /locus_tag="BSU_01270" /old_locus_tag="BSU01270" /label="rplX gene" CDS 140786..141325 /gene="rplE" /locus_tag="BSU_01280" /old_locus_tag="BSU01280" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L5 (BL6)" /protein_id="NP_388009.1" /db_xref="EnsemblGenomes-Gn:BSU01280" /db_xref="EnsemblGenomes-Tr:CAB11904" /db_xref="GOA:P12877" /db_xref="InterPro:IPR002132" /db_xref="InterPro:IPR020929" /db_xref="InterPro:IPR020930" /db_xref="InterPro:IPR022803" /db_xref="InterPro:IPR031309" /db_xref="InterPro:IPR031310" /db_xref="PDB:3J3V" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10760" /db_xref="UniProtKB/Swiss-Prot:P12877" /translation="MNRLKEKYNKEIAPALMTKFNYDSVMQVPKIEKIVINMGVGDAV QNAKAIDSAVEELTFIAGQKPVVTRAKKSIAGFRLREGMPIGAKVTLRGERMYDFLDK LISVSLPRVRDFRGVSKKSFDGRGNYTLGIKEQLIFPEIDYDKVTKVRGMDIVIVTTA NTDEEARELLTQVGMPFQK*" /label="rplE CDS" gene 140786..141325 /gene="rplE" /locus_tag="BSU_01280" /old_locus_tag="BSU01280" /label="rplE gene" CDS 141348..141533 /gene="rpsNA" /locus_tag="BSU_01290" /old_locus_tag="BSU01290" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 17163968, 19648245, 20208344, 27561249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17163968, 19648245, 20208344, 27561249; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S14" /protein_id="NP_388010.1" /db_xref="EnsemblGenomes-Gn:BSU01290" /db_xref="EnsemblGenomes-Tr:CAB11905" /db_xref="GOA:P12878" /db_xref="InterPro:IPR001209" /db_xref="InterPro:IPR018271" /db_xref="InterPro:IPR023053" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10761" /db_xref="UniProtKB/Swiss-Prot:P12878" /translation="MAKKSMIAKQQRTPKFKVQEYTRCERCGRPHSVIRKFKLCRICF RELAYKGQIPGVKKASW*" /label="rpsNA CDS" gene 141348..141533 /gene="rpsNA" /locus_tag="BSU_01290" /old_locus_tag="BSU01290" /label="rpsNA gene" CDS 141565..141963 /gene="rpsH" /locus_tag="BSU_01300" /old_locus_tag="BSU01300" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S8 (BS8)" /protein_id="NP_388011.2" /db_xref="EnsemblGenomes-Gn:BSU01300" /db_xref="EnsemblGenomes-Tr:CAB11906" /db_xref="GOA:P12879" /db_xref="InterPro:IPR000630" /db_xref="InterPro:IPR035987" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10762" /db_xref="UniProtKB/Swiss-Prot:P12879" /translation="MVMTDPIADMLTRIRNANMVRHEKLEIPASKLKREIAEILKREG FIRDVEFVEDSKQGIIRVFLKYGQNNERVITGLKRISKPGLRVYAKSNEVPRVLNGLG IAIISTSQGVLTDKEARAKQAGGEVLAYVW*" /label="rpsH CDS" gene 141565..141963 /gene="rpsH" /locus_tag="BSU_01300" /old_locus_tag="BSU01300" /label="rpsH gene" downshifts complement(141966) /Source="Nicolas_upshifts" /id="D51" /incds=0 /nref=1 /ntot=74 /MaxReadThrough="2.68318" /MaxDrop="2.55712" /score="5.40276403" /energy="-15.9" /TU="NA" /idTUdmin="U99" /TUdmin="-3586" /isTUend="FALSE" /label="downshifts" CDS 141993..142532 /gene="rplF" /locus_tag="BSU_01310" /old_locus_tag="BSU01310" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 25330043; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L6 (BL8)" /protein_id="NP_388012.1" /db_xref="EnsemblGenomes-Gn:BSU01310" /db_xref="EnsemblGenomes-Tr:CAB11907" /db_xref="GOA:P46898" /db_xref="InterPro:IPR000702" /db_xref="InterPro:IPR002358" /db_xref="InterPro:IPR019906" /db_xref="InterPro:IPR020040" /db_xref="InterPro:IPR036789" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11408" /db_xref="UniProtKB/Swiss-Prot:P46898" /translation="MSRVGKKLLEIPSDVTVTLNDNNTVAVKGPKGELTRTFHPDMEI KVEDNVLTVARPSDQKEHRALHGTTRSLLGNMVEGVSKGFERGLELVGVGYRASKSGN KLVLNVGYSHPVEIVPEEGIEIEVPSQTKVVVKGTDKERVGAIAANIRAVRSPEPYKG KGIRYEGEVVRRKEGKSAK*" /label="rplF CDS" gene 141993..142532 /gene="rplF" /locus_tag="BSU_01310" /old_locus_tag="BSU01310" /label="rplF gene" CDS 142565..142927 /gene="rplR" /locus_tag="BSU_01320" /old_locus_tag="BSU01320" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L18" /protein_id="NP_388013.2" /db_xref="EnsemblGenomes-Gn:BSU01320" /db_xref="EnsemblGenomes-Tr:CAB11908" /db_xref="GOA:P46899" /db_xref="InterPro:IPR004389" /db_xref="InterPro:IPR005484" /db_xref="PDB:3J3V" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11409" /db_xref="UniProtKB/Swiss-Prot:P46899" /translation="MITKTSKNAARLKRHARVRAKLSGTAERPRLNVFRSNKHIYAQI IDDVNGVTLASASTLDKDLNVESTGDTSAATKVGELVAKRAAEKGISDVVFDRGGYLY HGRVKALADAAREAGLKF*" /label="rplR CDS" gene 142565..142927 /gene="rplR" /locus_tag="BSU_01320" /old_locus_tag="BSU01320" /label="rplR gene" CDS 142952..143452 /gene="rpsE" /locus_tag="BSU_01330" /old_locus_tag="BSU01330" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6211592, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6211592, 12682299; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S5" /protein_id="NP_388014.1" /db_xref="EnsemblGenomes-Gn:BSU01330" /db_xref="EnsemblGenomes-Tr:CAB11909" /db_xref="GOA:P21467" /db_xref="InterPro:IPR000851" /db_xref="InterPro:IPR005324" /db_xref="InterPro:IPR005712" /db_xref="InterPro:IPR013810" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR018192" /db_xref="InterPro:IPR020568" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10442" /db_xref="UniProtKB/Swiss-Prot:P21467" /translation="MRRIDPSKLELEERLVTVNRVAKVVKGGRRFRFAALVVVGDKNG HVGFGTGKAQEVPEAIRKAVEDAKKNLIEVPMVGTTIPHEIIGRFGAGNILLKPASEG TGVIAGGPVRAVLELAGVADILSKSLGSNTPINMIRATLQGLSELKRAEDVAKLRGKS VEELLG*" /label="rpsE CDS" gene 142952..143452 /gene="rpsE" /locus_tag="BSU_01330" /old_locus_tag="BSU01330" /label="rpsE gene" CDS 143466..143645 /gene="rpmD" /locus_tag="BSU_01340" /old_locus_tag="BSU01340" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L30 (BL27)" /protein_id="NP_388015.1" /db_xref="EnsemblGenomes-Gn:BSU01340" /db_xref="EnsemblGenomes-Tr:CAB11910" /db_xref="GOA:P19947" /db_xref="InterPro:IPR005996" /db_xref="InterPro:IPR016082" /db_xref="InterPro:IPR018038" /db_xref="InterPro:IPR036919" /db_xref="PDB:3J3V" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10443" /db_xref="UniProtKB/Swiss-Prot:P19947" /translation="MAKLEITLKRSVIGRPEDQRVTVRTLGLKKTNQTVVHEDNAAIR GMINKVSHLVSVKEQ*" /label="rpmD CDS" gene 143466..143645 /gene="rpmD" /locus_tag="BSU_01340" /old_locus_tag="BSU01340" /label="rpmD gene" CDS 143676..144116 /gene="rplO" /locus_tag="BSU_01350" /old_locus_tag="BSU01350" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15855514, 23002217" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15855514, 23002217; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L15" /protein_id="NP_388016.1" /db_xref="EnsemblGenomes-Gn:BSU01350" /db_xref="EnsemblGenomes-Tr:CAB11911" /db_xref="GOA:P19946" /db_xref="InterPro:IPR001196" /db_xref="InterPro:IPR005749" /db_xref="InterPro:IPR021131" /db_xref="InterPro:IPR030878" /db_xref="InterPro:IPR036227" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10444" /db_xref="UniProtKB/Swiss-Prot:P19946" /translation="MKLHELKPSEGSRKTRNRVGRGIGSGNGKTAGKGHKGQNARSGG GVRPGFEGGQMPLFQRLPKRGFTNINRKEYAVVNLDKLNGFAEGTEVTPELLLETGVI SKLNAGVKILGNGKLEKKLTVKANKFSASAKEAVEAAGGTAEVI*" /label="rplO CDS" gene 143676..144116 /gene="rplO" /locus_tag="BSU_01350" /old_locus_tag="BSU01350" /label="rplO gene" CDS 144118..145413 /gene="secY" /locus_tag="BSU_01360" /old_locus_tag="BSU01360" /function="16.1: Circulate" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9917412, 15341641, 15849754, 16850406, 23852076, 22720735, 27336478" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9917412, 15341641, 15849754, 16850406, 23852076, 22720735, 27336478; Product type t: transporter" /codon_start=1 /transl_table=11 /product="preprotein translocase subunit" /protein_id="NP_388017.1" /db_xref="EnsemblGenomes-Gn:BSU01360" /db_xref="EnsemblGenomes-Tr:CAB11912" /db_xref="GOA:P16336" /db_xref="InterPro:IPR002208" /db_xref="InterPro:IPR023201" /db_xref="InterPro:IPR026593" /db_xref="InterPro:IPR030659" /db_xref="SubtiList:BG10445" /db_xref="UniProtKB/Swiss-Prot:P16336" /translation="MFKTISNFMRVSDIRNKIIFTLLMLIVFRIGAFIPVPYVNAEAL QAQSQMGVFDLLNTFGGGALYQFSIFAMGITPYITASIIIQLLQMDVVPKFTEWSKQG EVGRRKLAQFTRYFTIVLGFIQALGMSYGFNNLANGMLIEKSGVSTYLIIALVLTGGT AFLMWLGEQITSHGVGNGISIIIFAGIVSSIPKTIGQIYETQFVGSNDQLFIHIVKVA LLVIAILAVIVGVIFIQQAVRKIAIQYAKGTGRSPAGGGQSTHLPLKVNPAGVIPVIF AVAFLITPRTIASFFGTNDVTKWIQNNFDNTHPVGMAIYVALIIAFTYFYAFVQVNPE QMADNLKKQGGYIPGVRPGKMTQDRITSILYRLTFVGSIFLAVISILPIFFIQFAGLP QSAQIGGTSLLIVVGVALETMKQLESQLVKRNYRGFMKN*" /label="secY CDS" gene 144118..145413 /gene="secY" /locus_tag="BSU_01360" /old_locus_tag="BSU01360" /label="secY gene" CDS 145468..146121 /gene="adk" /locus_tag="BSU_01370" /old_locus_tag="BSU01370" /EC_number="2.7.4.3" /function="16.2: Construct biomass (Anabolism)" /function="16.7: Manage energy" /experiment="publication(s) with functional evidences, PMID:8061005, 8288548, 9056261, 9715904, 11106368, 16452168" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8061005, 8288548, 9056261, 9715904, 11106368, 16452168; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="adenylate kinase" /protein_id="NP_388018.1" /db_xref="EnsemblGenomes-Gn:BSU01370" /db_xref="EnsemblGenomes-Tr:CAB11913" /db_xref="GOA:P16304" /db_xref="InterPro:IPR000850" /db_xref="InterPro:IPR006259" /db_xref="InterPro:IPR007862" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR033690" /db_xref="PDB:1P3J" /db_xref="PDB:2EU8" /db_xref="PDB:2OO7" /db_xref="PDB:2ORI" /db_xref="PDB:2OSB" /db_xref="PDB:2P3S" /db_xref="PDB:2QAJ" /db_xref="PDB:3DKV" /db_xref="PDB:3DL0" /db_xref="PDB:4MKF" /db_xref="PDB:4MKG" /db_xref="PDB:4MKH" /db_xref="PDB:4QBF" /db_xref="PDB:4QBG" /db_xref="PDB:4TYP" /db_xref="PDB:4TYQ" /db_xref="SubtiList:BG10446" /db_xref="UniProtKB/Swiss-Prot:P16304" /translation="MNLVLMGLPGAGKGTQGERIVEDYGIPHISTGDMFRAAMKEETP LGLEAKSYIDKGELVPDEVTIGIVKERLGKDDCERGFLLDGFPRTVAQAEALEEILEE YGKPIDYVINIEVDKDVLMERLTGRRICSVCGTTYHLVFNPPKTPGICDKDGGELYQR ADDNEETVSKRLEVNMKQTQPLLDFYSEKGYLANVNGQQDIQDVYADVKDLLGGLKK* " /label="adk CDS" gene 145468..146121 /gene="adk" /locus_tag="BSU_01370" /old_locus_tag="BSU01370" /label="adk gene" CDS 146118..146864 /gene="mapA" /locus_tag="BSU_01380" /old_locus_tag="BSU01380" /EC_number="3.4.11.18" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:16207374, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16207374, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methionine aminopeptidase" /protein_id="NP_388019.1" /db_xref="EnsemblGenomes-Gn:BSU01380" /db_xref="EnsemblGenomes-Tr:CAB11914" /db_xref="GOA:P19994" /db_xref="InterPro:IPR000994" /db_xref="InterPro:IPR001714" /db_xref="InterPro:IPR002467" /db_xref="InterPro:IPR036005" /db_xref="SubtiList:BG10447" /db_xref="UniProtKB/Swiss-Prot:P19994" /translation="MIICKTPRELGIMREAGRIVALTHEELKKHIKPGISTKELDQIA ERFIKKQGAIPSFKGYNGFRGSICVSVNEELVHGIPGSRVLKDGDIISIDIGAKLNGY HGDSAWTYPVGNISDDDKKLLEVTEESLYKGLQEAKPGERLSNISHAIQTYVENEQFS VVREYVGHGVGQDLHEDPQIPHYGPPNKGPRLKPGMVLAIEPMVNAGSRYVKTLADNW TVVTVDGKKCAHFEHTIAITETGFDILTRV*" /label="mapA CDS" gene 146118..146864 /gene="mapA" /locus_tag="BSU_01380" /old_locus_tag="BSU01380" /label="mapA gene" CDS 146903..147127 /gene="ybzG" /locus_tag="BSU_01389" /old_locus_tag="BSU01389" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17157877; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative ribosome binding protein" /protein_id="YP_003097669.1" /db_xref="EnsemblGenomes-Gn:BSU01389" /db_xref="EnsemblGenomes-Tr:CAX52539" /db_xref="UniProtKB/Swiss-Prot:C0H3S8" /translation="MIGQKAWVNIGKTEFILLLVVGILTIINVLTADGEKRTFHSPKK KNINHLTLYDCVSPEVQNSINETGRVTNFF*" /label="ybzG CDS" gene 146903..147127 /gene="ybzG" /locus_tag="BSU_01389" /old_locus_tag="BSU01389" /label="ybzG gene" CDS 147176..147394 /gene="infA" /locus_tag="BSU_01390" /old_locus_tag="BSU01390" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9868784, 20477873, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="initiation factor IF-I" /protein_id="NP_388020.1" /db_xref="EnsemblGenomes-Gn:BSU01390" /db_xref="EnsemblGenomes-Tr:CAB11915" /db_xref="GOA:P20458" /db_xref="InterPro:IPR004368" /db_xref="InterPro:IPR006196" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR022967" /db_xref="SubtiList:BG11043" /db_xref="UniProtKB/Swiss-Prot:P20458" /translation="MAKDDVIEVEGTIVETLPNAMFKVELENGHTVLAHVSGKIRMHF IRILPGDKVTVELSPYDLTRGRITYRYK*" /label="infA CDS" gene 147176..147394 /gene="infA" /locus_tag="BSU_01390" /old_locus_tag="BSU01390" /label="infA gene" CDS 147428..147541 /gene="rpmJ" /locus_tag="BSU_01400" /old_locus_tag="BSU01400" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1783905, 23002217, 24335279" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1783905, 23002217, 24335279; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L36 (ribosomal protein B)" /protein_id="NP_388021.1" /db_xref="EnsemblGenomes-Gn:BSU01400" /db_xref="EnsemblGenomes-Tr:CAB11916" /db_xref="GOA:P20278" /db_xref="InterPro:IPR000473" /db_xref="InterPro:IPR035977" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11042" /db_xref="UniProtKB/Swiss-Prot:P20278" /translation="MKVRPSVKPICEKCKVIRRKGKVMVICENPKHKQKQG*" /label="rpmJ CDS" gene 147428..147541 /gene="rpmJ" /locus_tag="BSU_01400" /old_locus_tag="BSU01400" /label="rpmJ gene" CDS 147564..147929 /gene="rpsM" /locus_tag="BSU_01410" /old_locus_tag="BSU01410" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S13" /protein_id="NP_388022.2" /db_xref="EnsemblGenomes-Gn:BSU01410" /db_xref="EnsemblGenomes-Tr:CAB11917" /db_xref="GOA:P20282" /db_xref="InterPro:IPR001892" /db_xref="InterPro:IPR010979" /db_xref="InterPro:IPR018269" /db_xref="InterPro:IPR019980" /db_xref="InterPro:IPR027437" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10730" /db_xref="UniProtKB/Swiss-Prot:P20282" /translation="MARIAGVDIPRDKRVVISLTYIFGIGRTTAQQVLKEAGVSEDTR VRDLTEEELGKIRDIIDKLKVEGDLRREVSLNIKRLIEIGSYRGIRHRRGLPVRGQNS KNNARTRKGPRRTVANKKK*" /label="rpsM CDS" gene 147564..147929 /gene="rpsM" /locus_tag="BSU_01410" /old_locus_tag="BSU01410" /label="rpsM gene" CDS 147950..148345 /gene="rpsK" /locus_tag="BSU_01420" /old_locus_tag="BSU01420" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10217780, 12682299, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10217780, 12682299, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S11 (BS11)" /protein_id="NP_388023.1" /db_xref="EnsemblGenomes-Gn:BSU01420" /db_xref="EnsemblGenomes-Tr:CAB11918" /db_xref="GOA:P04969" /db_xref="InterPro:IPR001971" /db_xref="InterPro:IPR018102" /db_xref="InterPro:IPR019981" /db_xref="InterPro:IPR036967" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10731" /db_xref="UniProtKB/Swiss-Prot:P04969" /translation="MAAARKSNTRKRRVKKNIESGIAHIRSTFNNTIVTITDTHGNAI SWSSAGALGFRGSRKSTPFAAQMAAETAAKGSIEHGLKTLEVTVKGPGSGREAAIRAL QAAGLEVTAIRDVTPVPHNGCRPPKRRRV*" /label="rpsK CDS" gene 147950..148345 /gene="rpsK" /locus_tag="BSU_01420" /old_locus_tag="BSU01420" /label="rpsK gene" S_feature 148346..148521 /Source="Nicolas_S_feature" /locus_tag="new_148755_148930" /HighExp="G135, dia5, Lbexp, S0, aero, dia0, T-4.40H, G150, Paraq, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA, SigA, SigA, SigA, SigA, SigWXY, SigA, SigA" /TUlongPSig="1, 1, 0.997, 1, 1, 0.999, 1, 1, 0.947" /label="S56" CDS 148522..149466 /gene="rpoA" /locus_tag="BSU_01430" /old_locus_tag="BSU01430" /EC_number="2.7.7.6" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1484484, 6811591, 9594570, 10972808, 12682299, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1484484, 6811591, 9594570, 10972808, 12682299, 22720735; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="RNA polymerase (alpha subunit)" /protein_id="NP_388024.1" /db_xref="EnsemblGenomes-Gn:BSU01430" /db_xref="EnsemblGenomes-Tr:CAB11919" /db_xref="GOA:P20429" /db_xref="InterPro:IPR011260" /db_xref="InterPro:IPR011262" /db_xref="InterPro:IPR011263" /db_xref="InterPro:IPR011773" /db_xref="InterPro:IPR036603" /db_xref="InterPro:IPR036643" /db_xref="PDB:1Z3E" /db_xref="PDB:3GFK" /db_xref="PDB:3IHQ" /db_xref="SubtiList:BG10732" /db_xref="UniProtKB/Swiss-Prot:P20429" /translation="MIEIEKPKIETVEISDDAKFGKFVVEPLERGYGTTLGNSLRRIL LSSLPGAAVTSIQIDGVLHEFSTIEGVVEDVTTIILHIKKLALKIYSDEEKTLEIDVQ GEGTVTAADITHDSDVEILNPDLHIATLGENASFRVRLTAQRGRGYTPADANKRDDQP IGVIPIDSIYTPVSRVSYQVENTRVGQVANYDKLTLDVWTDGSTGPKEAIALGSKILT EHLNIFVGLTDEAQHAEIMVEKEEDQKEKVLEMTIEELDLSVRSYNCLKRAGINTVQE LANKTEEDMMKVRNLGRKSLEEVKAKLEELGLGLRKDD*" /label="rpoA CDS" gene 148522..149466 /gene="rpoA" /locus_tag="BSU_01430" /old_locus_tag="BSU01430" /label="rpoA gene" CDS 149544..149906 /gene="rplQ" /locus_tag="BSU_01440" /old_locus_tag="BSU01440" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6801428, 10717392, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6801428, 10717392, 12682299; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L17 (BL15)" /protein_id="NP_388025.1" /db_xref="EnsemblGenomes-Gn:BSU01440" /db_xref="EnsemblGenomes-Tr:CAB11920" /db_xref="GOA:P20277" /db_xref="InterPro:IPR000456" /db_xref="InterPro:IPR036373" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11041" /db_xref="UniProtKB/Swiss-Prot:P20277" /translation="MSYRKLGRTSAQRKAMLRDLTTDLIINERIETTETRAKELRSVV EKMITLGKRGDLHARRQAAAYIRNEVANEENNQDALQKLFSDIATRYEERQGGYTRIM KLGPRRGDGAPMAIIELV*" /label="rplQ CDS" gene 149544..149906 /gene="rplQ" /locus_tag="BSU_01440" /old_locus_tag="BSU01440" /label="rplQ gene" downshifts 149908 /Source="Nicolas_upshifts" /id="D52" /incds=0 /nref=171 /ntot=259 /MaxReadThrough="7.50771" /MaxDrop="5.4374" /score="2.32634618" /energy="-10.5" /TU="U98" /idTUdmin="U98" /TUdmin="-5577" /isTUend="FALSE" /label="downshifts" S_feature 149953..150033 /Source="Nicolas_S_feature" /locus_tag="new_150362_150442" /HighExp="Cold, G180, G135, G150, H2O2, S0, C30, Oxctl, Paraq, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA, SigA, SigA, SigA, SigA, SigWXY, SigA, SigA" /TUlongPSig="1, 1, 0.997, 1, 1, 0.999, 1, 1, 0.947" /label="S57" CDS 150034..150879 /gene="ecfA" /locus_tag="BSU_01450" /old_locus_tag="BSU01450" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12110480, 21135102, 26052893; Product type t: transporter" /codon_start=1 /transl_table=11 /product="energizing coupling factor of ABC influx transporter (ATP-binding protein)" /protein_id="NP_388026.2" /db_xref="EnsemblGenomes-Gn:BSU01450" /db_xref="EnsemblGenomes-Tr:CAB11921" /db_xref="GOA:P40735" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR015856" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030947" /db_xref="SubtiList:BG11067" /db_xref="UniProtKB/Swiss-Prot:P40735" /translation="MNQNQLISVEDIVFRYRKDAERRALDGVSLQVYEGEWLAIVGHN GSGKSTLARALNGLILPESGDIEVAGIQLTEESVWEVRKKIGMVFQNPDNQFVGTTVR DDVAFGLENNGVPREEMIERVDWAVKQVNMQDFLDQEPHHLSGGQKQRVAIAGVIAAR PDIIILDEATSMLDPIGREEVLETVRHLKEQGMATVISITHDLNEAAKADRIIVMNGG KKYAEGPPEEIFKLNKELVRIGLDLPFSFQLSQLLRENGLALEENHLTQEGLVKELWT LQSKM*" /label="ecfA CDS" gene 150034..150879 /gene="ecfA" /locus_tag="BSU_01450" /old_locus_tag="BSU01450" /label="ecfA gene" CDS 150894..151724 /gene="ecfAB" /locus_tag="BSU_01460" /old_locus_tag="BSU01460" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12110480, 21135102, 26052893" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12110480, 21135102, 26052893; Product type t: transporter" /codon_start=1 /transl_table=11 /product="energizing coupling factor of ABC influx transporter (ATP-binding protein)" /protein_id="NP_388027.1" /db_xref="EnsemblGenomes-Gn:BSU01460" /db_xref="EnsemblGenomes-Tr:CAB11922" /db_xref="GOA:P70970" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR015856" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030946" /db_xref="SubtiList:BG11989" /db_xref="UniProtKB/Swiss-Prot:P70970" /translation="MKTPFERLALYDINASIKEGSYVAVIGHTGSGKSTLLQHLNGLL KPTKGQISLGSTVIQAGKKNKDLKKLRKKVGIVFQFPEHQLFEETVLKDISFGPMNFG VKKEDAEQKAREMLQLVGLSEELLDRSPFELSGGQMRRVAIAGVLAMDPEVLVLDEPT AGLDPRGRKEIMDMFYELHQRGNLTTILVTHSMEDAAAYADEMIVMHKGTIQASGSPR DLFLKGEEMAGWGLDLPETIKFQRHLEAALGVRFNEPMLTIEDAAAEIRALFQGEKTL *" /label="ecfAB CDS" gene 150894..151724 /gene="ecfAB" /locus_tag="BSU_01460" /old_locus_tag="BSU01460" /label="ecfAB gene" CDS 151721..152518 /gene="ecfT" /locus_tag="BSU_01470" /old_locus_tag="BSU01470" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16850406, 18931129, 21135102, 26052893; Product type t : transporter" /codon_start=1 /transl_table=11 /product="component of the influx ECF transporters" /protein_id="NP_388028.2" /db_xref="EnsemblGenomes-Gn:BSU01470" /db_xref="EnsemblGenomes-Tr:CAB11923" /db_xref="GOA:P70972" /db_xref="InterPro:IPR003339" /db_xref="InterPro:IPR024919" /db_xref="SubtiList:BG11990" /db_xref="UniProtKB/Swiss-Prot:P70972" /translation="MMDSMIIGKYVPGTSLVHRLDPRTKLITIFLFVCIVFLANNVQT YALLGLFTIGVVSLTRVPFSFLMKGLKPIIWIVLFTFLLHILMTHEGPIIFQIGFFKV YEGGLVQGIFISLRFVYLILITTLLTLTTTPIEITDGMEQLLNPLKKLKLPVHELALM MSISLRFIPTLMEETDKIMKAQMARGVDFTSGPVKERVKAIVPLLVPLFVSAFKRAEE LAVAMEARGYQGGEGRTKYRKLVWTGKDTSVIVSLIVLAALLFFLRA*" /label="ecfT CDS" gene 151721..152518 /gene="ecfT" /locus_tag="BSU_01470" /old_locus_tag="BSU01470" /label="ecfT gene" CDS 152528..153271 /gene="truA" /locus_tag="BSU_01480" /old_locus_tag="BSU01480" /EC_number="5.4.99.12" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10529181, 15353568, 17114947, 17466622; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA pseudouridine (38-40) synthase" /protein_id="NP_388029.2" /db_xref="EnsemblGenomes-Gn:BSU01480" /db_xref="EnsemblGenomes-Tr:CAB11924" /db_xref="GOA:P70973" /db_xref="InterPro:IPR001406" /db_xref="InterPro:IPR020095" /db_xref="InterPro:IPR020097" /db_xref="InterPro:IPR020103" /db_xref="SubtiList:BG11992" /db_xref="UniProtKB/Swiss-Prot:P70973" /translation="MRLKCTISYDGHLFNGYQVQPGKRTVQDELEKALAVLHKSKDRI PVVSSGRTDSGVHAAGQVIHFDTPLSIPAERWPYALNALLPDDIAVKQAEIADDGFHA RFSAVKKEYRYFVYTEKHPDVFKRHYAYHFSYRLNVQDMREAAKHLIGTHDFTSFCAA KTEVQDKVRTIYELDWTETADGLQMRITGSGFLYNMVRIIAGTLLDAGIGKISPDEVK SMLEAKDREAAGRTAPGHGLYLWNVYYDN*" /label="truA CDS" gene 152528..153271 /gene="truA" /locus_tag="BSU_01480" /old_locus_tag="BSU01480" /label="truA gene" S_feature complement(152630..153098) /Source="Nicolas_S_feature" /locus_tag="new_153039_153507_c" /HighExp="S6, S8, S7, C30, G135, BT, S5, C90, M/G, Pyr" /AntisenseName="truA" /AntisenseCor="-0.30232258010971202" /AntisenseRegPval="-6.4" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S58" promotor_-35 152763..152768 /Source="Nicolas_upshift_promotors" /id="U100" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.478521478521479" /psig="0.478521478521479" /xcortree=2469 /SigmaFactorBS="cggctgagagatggccatatgCCTTAAatgcactgcttccgG ACGATATCGCAGTCAAAcaggcagaaattgcggatgatgggttccatgcacgatttag c" /listShort="NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 152783..152800 /Source="Nicolas_upshift_promotors" /id="U100" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.478521478521479" /psig="0.478521478521479" /xcortree=2469 /SigmaFactorBS="cggctgagagatggccatatgCCTTAAatgcactgcttccgG ACGATATCGCAGTCAAAcaggcagaaattgcggatgatgggttccatgcacgatttag c" /listShort="NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 152802 /Source="Nicolas_upshifts" /id="U100" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.478521478521479" /psig="0.478521478521479" /xcortree=2469 /SigmaFactorBS="cggctgagagatggccatatgCCTTAAatgcactgcttccgG ACGATATCGCAGTCAAAcaggcagaaattgcggatgatgggttccatgcacgatttag c" /listShort="NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(153098..153117) /Source="Nicolas_upshift_promotors" /id="U101" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1250 /SigmaFactorBS="ttcacctcatcgggagaaatttttccaatacctgcatcaagC AAAGTACCCgcaataattctgACCATATTATATAAGAAACCgctgcctgtgatccgca t" /listShort="S58" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(153120) /Source="Nicolas_upshifts" /id="U101" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1250 /SigmaFactorBS="ttcacctcatcgggagaaatttttccaatacctgcatcaagC AAAGTACCCgcaataattctgACCATATTATATAAGAAACCgctgcctgtgatccgca t" /listShort="S58" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(153130..153139) /Source="Nicolas_upshift_promotors" /id="U101" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1250 /SigmaFactorBS="ttcacctcatcgggagaaatttttccaatacctgcatcaagC AAAGTACCCgcaataattctgACCATATTATATAAGAAACCgctgcctgtgatccgca t" /listShort="S58" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 153291..153297 /Source="Nicolas_upshift_promotors" /id="U102" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2644 /SigmaFactorBS="ttactatgacaactaaaccaggtgtataatattttCTTGACA gagtctgcataaagTTATAAGATATCATATGGTAtgtatttcaaccccacgataagcc c" /listShort="NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 153312..153331 /Source="Nicolas_upshift_promotors" /id="U102" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2644 /SigmaFactorBS="ttactatgacaactaaaccaggtgtataatattttCTTGACA gagtctgcataaagTTATAAGATATCATATGGTAtgtatttcaaccccacgataagcc c" /listShort="NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 153316 /Source="Nicolas_upshifts" /id="U102" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2644 /SigmaFactorBS="ttactatgacaactaaaccaggtgtataatattttCTTGACA gagtctgcataaagTTATAAGATATCATATGGTAtgtatttcaaccccacgataagcc c" /listShort="NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 153328..153384 /gene="ldlM" /locus_tag="BSU_misc_RNA_4" /product="putative L13_leader" /note="Evidence 3: Putative function from multiple computational evidences; Product type n: RNA" /label="ldlM RNA" gene 153328..153384 /gene="ldlM" /locus_tag="BSU_misc_RNA_4" /label="ldlM gene" CDS 153433..153870 /gene="rplM" /locus_tag="BSU_01490" /old_locus_tag="BSU01490" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10781545, 12682299, 23504016, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10781545, 12682299, 23504016, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L13" /protein_id="NP_388030.2" /db_xref="EnsemblGenomes-Gn:BSU01490" /db_xref="EnsemblGenomes-Tr:CAB11925" /db_xref="GOA:P70974" /db_xref="InterPro:IPR005822" /db_xref="InterPro:IPR005823" /db_xref="InterPro:IPR023563" /db_xref="InterPro:IPR036899" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11970" /db_xref="UniProtKB/Swiss-Prot:P70974" /translation="MRTTPMANASTIERKWLVVDAAGKTLGRLSSEVAAILRGKHKPT YTPHVDTGDHVIIINAEKIELTGKKLTDKIYYRHTQHPGGLKSRTALEMRTNYPEKML ELAIKGMLPKGSLGRQMFKKLNVYRGSEHPHEAQKPEVYELRG*" /label="rplM CDS" gene 153433..153870 /gene="rplM" /locus_tag="BSU_01490" /old_locus_tag="BSU01490" /label="rplM gene" CDS 153891..154283 /gene="rpsI" /locus_tag="BSU_01500" /old_locus_tag="BSU01500" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 19653700, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S9" /protein_id="NP_388031.1" /db_xref="EnsemblGenomes-Gn:BSU01500" /db_xref="EnsemblGenomes-Tr:CAB11926" /db_xref="GOA:P21470" /db_xref="InterPro:IPR000754" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR020574" /db_xref="InterPro:IPR023035" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19007" /db_xref="UniProtKB/Swiss-Prot:P21470" /translation="MAQVQYYGTGRRKSSVARVRLVPGEGRIVVNNREISEHIPSAAL IEDIKQPLTLTETAGTYDVLVNVHGGGLSGQAGAIRHGIARALLEADPEYRTTLKRAG LLTRDARMKERKKYGLKGARRAPQFSKR*" /label="rpsI CDS" gene 153891..154283 /gene="rpsI" /locus_tag="BSU_01500" /old_locus_tag="BSU01500" /label="rpsI gene" downshifts 154258 /Source="Nicolas_upshifts" /id="D53" /incds=0 /nref=262 /ntot=282 /MaxReadThrough="4.65387" /MaxDrop="8.11906" /score="30.5093496" /energy="-13.3" /TU="U98,U100,U102" /idTUdmin="U98" /TUdmin="-1227" /isTUend="FALSE" /label="downshifts" promotor_-35 154400..154407 /Source="Nicolas_upshift_promotors" /id="U103" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.97002997002997" /psig="0.999000999001" /xcortree=2051 /SigmaFactorBS="ctgaatggacgcttgacggggttaagcaaatTGTTTGTTtat aaacggtctcTTTGTAATAATCATGGTAGAtttcattcttattcaattggaagttcgg t" /listShort="S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 154421..154440 /Source="Nicolas_upshift_promotors" /id="U103" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.97002997002997" /psig="0.999000999001" /xcortree=2051 /SigmaFactorBS="ctgaatggacgcttgacggggttaagcaaatTGTTTGTTtat aaacggtctcTTTGTAATAATCATGGTAGAtttcattcttattcaattggaagttcgg t" /listShort="S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 154429..154710 /Source="Nicolas_S_feature" /locus_tag="new_154838_155119" /HighExp="H2O2, G180, G135, Paraq, Diami, dia15, Oxctl, Cold, Heat, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, Sig-, SigA" /TUshortPSig="0.999, 1, 0.479, 1" /TUlongSig="SigA, SigA, SigA, SigA, SigA, SigA, SigWXY, SigA, SigA" /TUlongPSig="1, 1, 0.997, 1, 1, 0.999, 1, 1, 0.947" /label="S59" upshifts 154429 /Source="Nicolas_upshifts" /id="U103" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.97002997002997" /psig="0.999000999001" /xcortree=2051 /SigmaFactorBS="ctgaatggacgcttgacggggttaagcaaatTGTTTGTTtat aaacggtctcTTTGTAATAATCATGGTAGAtttcattcttattcaattggaagttcgg t" /listShort="S59, ybaJ" /GFF_Attribute="listLong" /label="upshifts" misc_feature 154709..154728 /Source="Nicolas_upshift_promotors" /id="U104" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.625374625374625" /psig="0.804195804195804" /xcortree=3216 /SigmaFactorBS="gtttttatgaacttttttctaaatatgcaaagggaaagcgat atcaatctagaaataTTTGTTATACTCTATACATTaaagtaaggagaagattcatgaa t" /listShort="ybaJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 154712 /Source="Nicolas_upshifts" /id="U104" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.625374625374625" /psig="0.804195804195804" /xcortree=3216 /SigmaFactorBS="gtttttatgaacttttttctaaatatgcaaagggaaagcgat atcaatctagaaataTTTGTTATACTCTATACATTaaagtaaggagaagattcatgaa t" /listShort="ybaJ" /GFF_Attribute="listLong" /label="upshifts" CDS 154747..155514 /gene="ybaJ" /locus_tag="BSU_01510" /old_locus_tag="BSU01510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26582911; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative methyltransferase" /protein_id="NP_388032.2" /db_xref="EnsemblGenomes-Gn:BSU01510" /db_xref="EnsemblGenomes-Tr:CAB11927" /db_xref="GOA:P70976" /db_xref="InterPro:IPR013216" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11994" /db_xref="UniProtKB/Swiss-Prot:P70976" /translation="MNALVAHNSKAWDKKVETGNEWTVAVEQQVIEQAKKGNWDIRVT PMKDVPKDWFPPIKGLKVLCLASGGGQQGPVLAAAGADVTVLDNSEKQLNQDRMIAER DGLTIHTVKGSMDDLSVFNDESFDVIVHPVANVFVENVLPVWKEAYRVLKRNGILISG FVNPVVFLFDTELEQQGVLKVKHSIPYADPEDLPKHKVKKLIENNEALEFGHSLEDQI KGQIDAGFIVTGFYEDKGGFVLDQYIHTYSATRSVKV*" /label="ybaJ CDS" gene 154747..155514 /gene="ybaJ" /locus_tag="BSU_01510" /old_locus_tag="BSU01510" /label="ybaJ gene" downshifts 155505 /Source="Nicolas_upshifts" /id="D54" /incds=0 /nref=215 /ntot=251 /MaxReadThrough="2.69346" /MaxDrop="6.09641" /score="4.42269359" /energy="-10.3" /TU="NA" /idTUdmin="U100" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 155644..155650 /Source="Nicolas_upshift_promotors" /id="U105" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=864 /SigmaFactorBS="ccttcatttgggcgaatttccaaccgaattcgGGCATTGttt catcatccaaaCCTCAAAATAATcggtaaaaggagagtgaatttatatggcagaagta c" /listShort="ybaK, cwlD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 155665..155676 /Source="Nicolas_upshift_promotors" /id="U105" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=864 /SigmaFactorBS="ccttcatttgggcgaatttccaaccgaattcgGGCATTGttt catcatccaaaCCTCAAAATAATcggtaaaaggagagtgaatttatatggcagaagta c" /listShort="ybaK, cwlD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 155672 /Source="Nicolas_upshifts" /id="U105" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=864 /SigmaFactorBS="ccttcatttgggcgaatttccaaccgaattcgGGCATTGttt catcatccaaaCCTCAAAATAATcggtaaaaggagagtgaatttatatggcagaagta c" /listShort="ybaK, cwlD" /GFF_Attribute="listLong" /label="upshifts" CDS 155700..156143 /gene="ybaK" /locus_tag="BSU_01520" /old_locus_tag="BSU01520" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 14679227, 16267290" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388033.1" /db_xref="EnsemblGenomes-Gn:BSU01520" /db_xref="EnsemblGenomes-Tr:CAB11928" /db_xref="GOA:P50862" /db_xref="InterPro:IPR019667" /db_xref="SubtiList:BG11503" /db_xref="UniProtKB/Swiss-Prot:P50862" /translation="MAEVLSFMDVKRQKDFELEKNLLKELSLRQIIQSVKDCLEPLFP FLHDERDIITEGCIDFAIEAYLLGGRFGIFGYYGESMQSISARSAREEEELRMEFFDY LYNWIHEQYATFDKNTVYEAARKFIKDWWTAGFVQREKQCKLRMR*" /label="ybaK CDS" gene 155700..156143 /gene="ybaK" /locus_tag="BSU_01520" /old_locus_tag="BSU01520" /label="ybaK gene" promotor_-35 156143..156148 /Source="Nicolas_upshift_promotors" /id="U106" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=973 /SigmaFactorBS="gttcaaagagaaaaacagtgtaagcttcgcatgcggtaATCA TAtttcccgaccctgtcCCATAGTTATGTAATAACGgacaagcgggaggggaagggat g" /listShort="cwlD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 156164..156182 /Source="Nicolas_upshift_promotors" /id="U106" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=973 /SigmaFactorBS="gttcaaagagaaaaacagtgtaagcttcgcatgcggtaATCA TAtttcccgaccctgtcCCATAGTTATGTAATAACGgacaagcgggaggggaagggat g" /listShort="cwlD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 156165 /Source="Nicolas_upshifts" /id="U106" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=973 /SigmaFactorBS="gttcaaagagaaaaacagtgtaagcttcgcatgcggtaATCA TAtttcccgaccctgtcCCATAGTTATGTAATAACGgacaagcgggaggggaagggat g" /listShort="cwlD" /GFF_Attribute="listLong" /label="upshifts" CDS 156203..156916 /gene="cwlD" /locus_tag="BSU_01530" /old_locus_tag="BSU01530" /EC_number="3.5.1.28" /function="16.13: Shape" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14679227, 16267290" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14679227, 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylmuramoyl-L-alanine amidase" /protein_id="NP_388034.1" /db_xref="EnsemblGenomes-Gn:BSU01530" /db_xref="EnsemblGenomes-Tr:CAB11929" /db_xref="GOA:P50864" /db_xref="InterPro:IPR002508" /db_xref="InterPro:IPR014234" /db_xref="SubtiList:BG11514" /db_xref="UniProtKB/Swiss-Prot:P50864" /translation="MRKKLKWLSFLLGFIILLFLFKYQFSNNDSWKPWSLPLSGKIIY LDPGHGGPDGGAVGGKLLEKDVTLEVAFRVRDYLQEQGALVIMTRESDTDLAPEGTKG YSRRKAEDLRQRVKLINHSEAELYISIHLNAIPSQKWSGAQSFYYGKYAENEKVAKYI QDELRRNLENTTRKAKRIHGIYLMQNVTKPGALIEVGFLSNPSEATLLGKPKYQDKVA SSIYKGILRYFTEKGDPPE*" /label="cwlD CDS" gene 156203..156916 /gene="cwlD" /locus_tag="BSU_01530" /old_locus_tag="BSU01530" /label="cwlD gene" upshifts 156961 /Source="Nicolas_upshifts" /id="U107" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.965034965034965" /psig="0.998001998001998" /xcortree=3187 /SigmaFactorBS="agaccctccggagtaatggagggttttcttgtggttctaagc ataagacacccgccatttatgTATGATATAATAATAATTGTaaacgaatacacaaaag g" /listShort="salA, S61, kbaA, S63, S64, rrnI-16S" /GFF_Attribute="listLong" /label="upshifts" misc_feature 156964..156983 /Source="Nicolas_upshift_promotors" /id="U107" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.965034965034965" /psig="0.998001998001998" /xcortree=3187 /SigmaFactorBS="agaccctccggagtaatggagggttttcttgtggttctaagc ataagacacccgccatttatgTATGATATAATAATAATTGTaaacgaatacacaaaag g" /listShort="salA, S61, kbaA, S63, S64, rrnI-16S" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 157012..158070 /gene="salA" /locus_tag="BSU_01540" /old_locus_tag="BSU01540" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11790741, 15126467, 26094643" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11790741, 15126467, 26094643; Product type r: regulator" /codon_start=1 /transl_table=11 /product="phosphorylation-dependent (Y327) transcriptionalregulator" /protein_id="NP_388035.1" /db_xref="EnsemblGenomes-Gn:BSU01540" /db_xref="EnsemblGenomes-Tr:CAB11930" /db_xref="GOA:P50863" /db_xref="InterPro:IPR000808" /db_xref="InterPro:IPR019591" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR033756" /db_xref="InterPro:IPR034904" /db_xref="SubtiList:BG11494" /db_xref="UniProtKB/Swiss-Prot:P50863" /translation="MIREDEVRKLVGEMREPFLQRPLGELDAVKEIKIKPEKRHISVK VALAKTGTAEQMQIQQEIVNVLKGAGAETVGLRFEELPEETVAKFRAPSAEKKTLLNM DNPPVFLAVASGKGGVGKSTVSVNLAISLARLGKKVGLIDADIYGFSVPDMMGITVRP TIEGEKLLPVERFGVKVMSMGFFVEENAPVVWRGPMLGKMLNNFFHEVEWGEVDYIVL DLPPGTGDVALDVHTMLPSCKEIIVSTPHPTAAFVAARAGSMAIKTDHEVVGVIENMA YYESAKTGEREYVFGKGGGDKLAEELNVPLLGRIPLKQPDWDKDQFAPSVYDENHPIG EIYQDIAKKIDAKMSVQV*" /label="salA CDS" gene 157012..158070 /gene="salA" /locus_tag="BSU_01540" /old_locus_tag="BSU01540" /label="salA gene" S_feature complement(157641..158105) /Source="Nicolas_S_feature" /locus_tag="new_158050_158514_c" /HighExp="S8, S7, S6, S5, C30, S4, C90, nit, ferm, Gly" /AntisenseName="salA" /AntisenseCor="-0.104183954485248" /AntisenseRegPval="-1.1000000000000001" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S60" downshifts 158056 /Source="Nicolas_upshifts" /id="D55" /incds=0 /nref=29 /ntot=155 /MaxReadThrough="5.44939" /MaxDrop="4.18382" /score="-4.46878413" /energy="-9.1" /TU="U107" /idTUdmin="U106" /TUdmin=1185 /isTUend="FALSE" /label="downshifts" S_feature 158101..158772 /Source="Nicolas_S_feature" /locus_tag="new_158510_159181" /HighExp="Lbtran, H2O2, Cold, Lbstat, dia5, M40t45, M0t90, M40t90, T0.30H, S1" /AntisenseName="gerD" /AntisenseCor="-0.24235509346425901" /AntisenseRegPval="-4.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S61" CDS complement(158106..158663) /gene="gerD" /locus_tag="BSU_01550" /old_locus_tag="BSU01550" /function="16.13: Shape" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17122337, 10618233, 10376819, 24530795" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17122337, 10618233, 10376819, 24530795; Product type f: factor" /codon_start=1 /transl_table=11 /product="lipoprotein factor mediating clustering of germination proteins" /protein_id="NP_388036.1" /db_xref="EnsemblGenomes-Gn:BSU01550" /db_xref="EnsemblGenomes-Tr:CAB11931" /db_xref="GOA:P16450" /db_xref="SubtiList:BG10644" /db_xref="UniProtKB/Swiss-Prot:P16450" /translation="MSKAKTLLMSCFLLLSVTACAPKDQAADMDYDQTKKMVVDILKT DDGKKAIKELLNDDAMNEALVIDQDAIKGTIEKTLTSKKGEEFWKNIFEDTDFAEGFA KTLQTEHEKVIKKLMKDPDYQKMLMSVMQDPGMDKKYSQLAKSQEFRSYLEEVINETL SSPLYKKQFEDELKKAAKDTAKESE*" /label="gerD CDS" gene complement(158106..158663) /gene="gerD" /locus_tag="BSU_01550" /old_locus_tag="BSU01550" /label="gerD gene" promotor_-10 complement(158695..158706) /Source="Nicolas_upshift_promotors" /id="U108" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=925 /SigmaFactorBS="tattcatcccctcaaaaatcgcgaacagcgatattttgttaT GTATAAttccaaacagatgAATCATATTAAAggtaagacaagtatgtgaaaggagctt a" /listShort="gerD, S60" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(158707) /Source="Nicolas_upshifts" /id="U108" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=925 /SigmaFactorBS="tattcatcccctcaaaaatcgcgaacagcgatattttgttaT GTATAAttccaaacagatgAATCATATTAAAggtaagacaagtatgtgaaaggagctt a" /listShort="gerD, S60" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(158720..158726) /Source="Nicolas_upshift_promotors" /id="U108" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=925 /SigmaFactorBS="tattcatcccctcaaaaatcgcgaacagcgatattttgttaT GTATAAttccaaacagatgAATCATATTAAAggtaagacaagtatgtgaaaggagctt a" /listShort="gerD, S60" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(158740..159369) /Source="Nicolas_S_feature" /locus_tag="new_159149_159778_c" /HighExp="S3, T5.0H, S4, S8, M9-stat, T4.0H, T3.30H, S7, T3.0H, S6" /AntisenseName="kbaA" /AntisenseCor="7.9344921760152495E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S62" CDS 158773..159369 /gene="kbaA" /locus_tag="BSU_01560" /old_locus_tag="BSU01560" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8576055, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8576055, 15849754, 16850406; Product type r: regulator" /codon_start=1 /transl_table=11 /product="inner membrane protein involved in activation ofthe KinB signaling pathway to sporulation" /protein_id="NP_388037.1" /db_xref="EnsemblGenomes-Gn:BSU01560" /db_xref="EnsemblGenomes-Tr:CAB11932" /db_xref="GOA:P16449" /db_xref="InterPro:IPR024164" /db_xref="SubtiList:BG10643" /db_xref="UniProtKB/Swiss-Prot:P16449" /translation="MKSRGLVRFFFSILAVGALITSIVGFALKWGEYRGLFLTFEAGQ IFSVLFWFIGVGMIFSVISQMGFFVFLTVHRFALEILRSSSLWNLLQLFFILFVAFDL MYVRFLFFGESGESLAGYAWLPVFLLIFGVITAYIKQKQSSKKTFVSSLFLMVVITAL EWFPALRVNDEDWLYLMLFPLMACNAFQLLMLPKFAAK*" /label="kbaA CDS" gene 158773..159369 /gene="kbaA" /locus_tag="BSU_01560" /old_locus_tag="BSU01560" /label="kbaA gene" S_feature 159370..160264 /Source="Nicolas_S_feature" /locus_tag="new_159779_160673" /HighExp="Lbstat, Lbtran, M0t90, M40t90, H2O2, BC, Glucon, S7, M40t45, S1" /AntisenseName="ybaN" /AntisenseCor="-2.6735901031407501E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S63" CDS complement(159370..160134) /gene="pdaB" /locus_tag="BSU_01570" /old_locus_tag="BSU01570" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12662922, 15547282, 15598884" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12662922, 15547282, 15598884; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="polysaccharide deacetylase involved in sporulation" /protein_id="NP_388038.1" /db_xref="EnsemblGenomes-Gn:BSU01570" /db_xref="EnsemblGenomes-Tr:CAB11933" /db_xref="GOA:P50865" /db_xref="InterPro:IPR002509" /db_xref="InterPro:IPR011330" /db_xref="InterPro:IPR014132" /db_xref="SubtiList:BG11416" /db_xref="UniProtKB/Swiss-Prot:P50865" /translation="MNHFYVWHIKRVKQLIIILIAAFAAASFFYIQRAVPLPVFSTDT GPKAIYKGETDSKDISLTFDISWGDERAEPILNTLKANGIKNATFFLSASWAERHPDT VARIVKDGHQIGSMGYAYKNYANLESSEIKKDMNRAQTAFEKLGVKDIQLLRPPTGQF NKNVLKVAKQYNYTVVHYSVNSQDWTNPGVEKIIDNVTKQVSGGDIILLHASDSAKQT EEALPDIIHQLKEKGLKNVTVGDLIANSDAKSAEVK*" /label="pdaB CDS" gene complement(159370..160134) /gene="pdaB" /locus_tag="BSU_01570" /old_locus_tag="BSU01570" /label="pdaB gene" promotor_-10 complement(160165..160183) /Source="Nicolas_upshift_promotors" /id="U109" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=979 /SigmaFactorBS="caacacccaatttaggctgtatgtgaagagacattttatcgG TTATAttcaattgtccatgcTCATAAGATGTAAAACAAGaatgatggacaagataagg a" /listShort="ybaN, S62" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(160185) /Source="Nicolas_upshifts" /id="U109" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=979 /SigmaFactorBS="caacacccaatttaggctgtatgtgaagagacattttatcgG TTATAttcaattgtccatgcTCATAAGATGTAAAACAAGaatgatggacaagataagg a" /listShort="ybaN, S62" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(160199..160204) /Source="Nicolas_upshift_promotors" /id="U109" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=979 /SigmaFactorBS="caacacccaatttaggctgtatgtgaagagacattttatcgG TTATAttcaattgtccatgcTCATAAGATGTAAAACAAGaatgatggacaagataagg a" /listShort="ybaN, S62" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 160242..160249 /Source="Nicolas_upshift_promotors" /id="U110" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp=1 /psig=1 /xcortree=2624 /SigmaFactorBS="gataaaatgtctcttcacatacagcctaaattgggtGTTGAC CTtttgataatatccgTGATATATTATTATTCGTCGctgataaacagctgacatcaac t" /listShort="S64, rrnI-16S, rrnI-23S, rrnI-5S, trnI-Asn, trnI-Thr, trnI-Gly, trnI-Arg, trnI-Pro, trnI-Ala, rrnH-16S, rrnH-23S, rrnH-5S, rrnG-16S" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 160264..160283 /Source="Nicolas_upshift_promotors" /id="U110" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp=1 /psig=1 /xcortree=2624 /SigmaFactorBS="gataaaatgtctcttcacatacagcctaaattgggtGTTGAC CTtttgataatatccgTGATATATTATTATTCGTCGctgataaacagctgacatcaac t" /listShort="S64, rrnI-16S, rrnI-23S, rrnI-5S, trnI-Asn, trnI-Thr, trnI-Gly, trnI-Arg, trnI-Pro, trnI-Ala, rrnH-16S, rrnH-23S, rrnH-5S, rrnG-16S" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 160266..160483 /Source="Nicolas_S_feature" /locus_tag="new_160675_160892" /HighExp="Diami, LBGstat, UNK1, H2O2, MG 15, Oxctl, MG-0.1, BMM, T-1.10H, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S64" upshifts 160266 /Source="Nicolas_upshifts" /id="U110" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp=1 /psig=1 /xcortree=2624 /SigmaFactorBS="gataaaatgtctcttcacatacagcctaaattgggtGTTGAC CTtttgataatatccgTGATATATTATTATTCGTCGctgataaacagctgacatcaac t" /listShort="S64, rrnI-16S, rrnI-23S, rrnI-5S, trnI-Asn, trnI-Thr, trnI-Gly, trnI-Arg, trnI-Pro, trnI-Ala, rrnH-16S, rrnH-23S, rrnH-5S, rrnG-16S" /GFF_Attribute="listLong" /label="upshifts" rRNA 160484..162037 /gene="rrnI-16S" /locus_tag="BSU_rRNA_23" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnI-16S rRNA" gene 160484..162037 /gene="rrnI-16S" /locus_tag="BSU_rRNA_23" /modified_by="User" /label="rrnI-16S gene" Polymorphism join(160830,160832) /Source="geneious" /ID="SNP_BsDelta6_161240_161239" /Polymorphism_Type="Insertion" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=0 /Amino_Acid_Change /CDS_Position /Change="C" /Codon_Change /Coverage=45 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides /Variant_Nucleotides="C" /Variant_P_Value="4.2e-57" /Variant_Raw_Frequency=41 /comment="rrnI-16S rRNA" /modified_by="User" / /label="Polymorphism_Delta6" rRNA 162202..165129 /gene="rrnI-23S" /locus_tag="BSU_rRNA_14" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnI-23S rRNA" gene 162202..165129 /gene="rrnI-23S" /locus_tag="BSU_rRNA_14" /label="rrnI-23S gene" rRNA 165185..165301 /gene="rrnI-5S" /locus_tag="BSU_rRNA_15" /product="ribosomal RNA-5S" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnI-5S rRNA" gene 165185..165301 /gene="rrnI-5S" /locus_tag="BSU_rRNA_15" /label="rrnI-5S gene" Polymorphism join(165341,165342) /Source="geneious" /ID="SNP_BsDelta6_165748_165749" /Polymorphism_Type="Deletion" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=2 /Amino_Acid_Change /CDS_Position /Change="-TC" /Codon_Change /Coverage="172 -> 174" /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides="TC" /Variant_Nucleotides /Variant_P_Value="1.5e-307" /Variant_Raw_Frequency=152 /comment="BSU_tRNA_23_Asn" /modified_by="User" / /label="Polymorphism_Delta6" Polymorphism join(165342,165344) /Source="geneious" /ID="SNP_BsDelta6_165751_165751" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change /CDS_Position /Change="C -> T" /Codon_Change /Coverage=172 /locus_tag /Protein_Effect /Reference_Frequency="1.2%" /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=168 /comment="BSU_tRNA_23_Asn" /modified_by="User" / /label="Polymorphism_Delta6" tRNA 165346..165417 /gene="trnI-Asn" /locus_tag="BSU_tRNA_23" /product="tRNA-Asn" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Asn(GUU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnI-Asn tRNA" gene 165346..165417 /gene="trnI-Asn" /locus_tag="BSU_tRNA_23" /label="trnI-Asn gene" Polymorphism join(165417,165419) /Source="geneious" /ID="SNP_BsDelta6_165826_165825" /Polymorphism_Type="Insertion" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=0 /Amino_Acid_Change /CDS_Position /Change="C" /Codon_Change /Coverage=163 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides /Variant_Nucleotides="C" /Variant_P_Value=0 /Variant_Raw_Frequency=160 /comment="BSU_tRNA_23_Asn" /modified_by="User" / /label="Polymorphism_Delta6" tRNA 165423..165495 /gene="trnI-Thr" /locus_tag="BSU_tRNA_24" /product="tRNA-Thr" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Thr(GGU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnI-Thr tRNA" gene 165423..165495 /gene="trnI-Thr" /locus_tag="BSU_tRNA_24" /label="trnI-Thr gene" tRNA 165552..165626 /gene="trnI-Gly" /locus_tag="BSU_tRNA_25" /product="tRNA-Gly" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gly(GCC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnI-Gly tRNA" gene 165552..165626 /gene="trnI-Gly" /locus_tag="BSU_tRNA_25" /label="trnI-Gly gene" Polymorphism join(165630,165632) /Source="geneious" /ID="SNP_BsDelta6_166038_166037" /Polymorphism_Type="Insertion" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=0 /Amino_Acid_Change /CDS_Position /Change="T" /Codon_Change /Coverage=154 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=148 /comment="-" /modified_by="User" / /label="Polymorphism_Delta6" tRNA 165658..165734 /gene="trnI-Arg" /locus_tag="BSU_tRNA_26" /product="tRNA-Arg" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Arg(AGC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnI-Arg tRNA" gene 165658..165734 /gene="trnI-Arg" /locus_tag="BSU_tRNA_26" /label="trnI-Arg gene" tRNA 165762..165838 /gene="trnI-Pro" /locus_tag="BSU_tRNA_27" /product="tRNA-Pro" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnI-Pro tRNA" gene 165762..165838 /gene="trnI-Pro" /locus_tag="BSU_tRNA_27" /label="trnI-Pro gene" tRNA 165847..165922 /gene="trnI-Ala" /locus_tag="BSU_tRNA_28" /product="tRNA-Ala" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ala(UGC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnI-Ala tRNA" gene 165847..165922 /gene="trnI-Ala" /locus_tag="BSU_tRNA_28" /label="trnI-Ala gene" Polymorphism join(165937,165938) /Source="geneious" /ID="SNP_BsDelta6_166344_166344" /Polymorphism_Type="Deletion" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change /CDS_Position /Change="-G" /Codon_Change /Coverage=132 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides="G" /Variant_Nucleotides /Variant_P_Value="4.9e-75" /Variant_Raw_Frequency=130 /comment="-" /modified_by="User" / /label="Polymorphism_Delta6" rRNA 166093..167646 /gene="rrnH-16S" /locus_tag="BSU_rRNA_16" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnH-16S rRNA" gene 166093..167646 /gene="rrnH-16S" /locus_tag="BSU_rRNA_16" /label="rrnH-16S gene" rRNA 167811..170738 /gene="rrnH-23S" /locus_tag="BSU_rRNA_29" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnH-23S rRNA" gene 167811..170738 /gene="rrnH-23S" /locus_tag="BSU_rRNA_29" /label="rrnH-23S gene" rRNA 170794..170911 /gene="rrnH-5S" /locus_tag="BSU_rRNA_24" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnH-5S rRNA" gene 170794..170911 /gene="rrnH-5S" /locus_tag="BSU_rRNA_24" /label="rrnH-5S gene" rRNA 171095..172648 /gene="rrnG-16S" /locus_tag="BSU_rRNA_25" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnG-16S rRNA" gene 171095..172648 /gene="rrnG-16S" /locus_tag="BSU_rRNA_25" /label="rrnG-16S gene" rRNA 172813..175740 /gene="rrnG-23S" /locus_tag="BSU_rRNA_27" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnG-23S rRNA" gene 172813..175740 /gene="rrnG-23S" /locus_tag="BSU_rRNA_27" /label="rrnG-23S gene" rRNA 175796..175914 /gene="rrnG-5S" /locus_tag="BSU_rRNA_28" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnG-5S rRNA" gene 175796..175914 /gene="rrnG-5S" /locus_tag="BSU_rRNA_28" /label="rrnG-5S gene" S_feature 175915..176523 /Source="Nicolas_S_feature" /locus_tag="new_176316_176924" /HighExp="G180, G135, C30, Oxctl, Paraq, Cold, G150, H2O2, Heat, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S65" promotor_-35 176491..176495 /Source="Nicolas_upshift_promotors" /id="U111" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=2510 /SigmaFactorBS="tgagccatttttttcttcagcaatcaTCTTGcgtaattgata aaaaTTTATTATGATACTCTTTGTatgacaactccttgcctcaatacaatatactcaa c" /listShort="S66, ybaR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 176511..176530 /Source="Nicolas_upshift_promotors" /id="U111" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=2510 /SigmaFactorBS="tgagccatttttttcttcagcaatcaTCTTGcgtaattgata aaaaTTTATTATGATACTCTTTGTatgacaactccttgcctcaatacaatatactcaa c" /listShort="S66, ybaR" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 176525..176681 /Source="Nicolas_S_feature" /locus_tag="new_176926_177082" /HighExp="LBGstat, G180, G135, dia15, C30, Oxctl, LPhT, G150, Heat, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S66" upshifts 176525 /Source="Nicolas_upshifts" /id="U111" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=2510 /SigmaFactorBS="tgagccatttttttcttcagcaatcaTCTTGcgtaattgata aaaaTTTATTATGATACTCTTTGTatgacaactccttgcctcaatacaatatactcaa c" /listShort="S66, ybaR" /GFF_Attribute="listLong" /label="upshifts" CDS 176682..178118 /gene="ybaR" /locus_tag="BSU_01580" /old_locus_tag="BSU01580" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388039.1" /db_xref="EnsemblGenomes-Gn:BSU01580" /db_xref="EnsemblGenomes-Tr:CAB11934" /db_xref="GOA:P55189" /db_xref="InterPro:IPR001902" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR011547" /db_xref="InterPro:IPR018045" /db_xref="InterPro:IPR036513" /db_xref="SubtiList:BG11562" /db_xref="UniProtKB/Swiss-Prot:P55189" /translation="MNNSFTLKQQWFGNIRKDILAGILVALALIPEAIGFSIIAGVDP MVGLYASFCIAIIISIFGGRPGMISAATGSMAVVMVSLVADHGLQYLFAATILTGIIQ VILGISKIARLMKFIPRSVMIGFVNALAILIFSAQLPQFEGASWSMYAMLAGSLVIIY VLPRFTTAVPSPLVAIIVMTIIAVTFHVDVRTVGDMGNISSSLPHFLIPDVPFTFETL QIIFPYSIALAFVGLLESLLTAQIIDEMTDTDSDKNKESRGQGIANIVTGFFGGMAGC AMIGQSVINTKAGGRGRLSAFVAGAFLMFLIAVLSHVVVKIPMAALVAVMVMVSVGTF DWSSLKGLKKAPLTDSIVMVVTVVTVVVTDDLSKGVFVGVLLSAVFFVAKISKLKIVS HAEDQKLRTYQVKGQIFFASVTDLTNAFIYQEDIERVVIDLTEAHVWDDSGAAALDKI VAKFKEQGIEAELKGLNKASKSLMKQMA*" /label="ybaR CDS" gene 176682..178118 /gene="ybaR" /locus_tag="BSU_01580" /old_locus_tag="BSU01580" /label="ybaR gene" downshifts 178107 /Source="Nicolas_upshifts" /id="D56" /incds=0 /nref=144 /ntot=228 /MaxReadThrough="2.81758" /MaxDrop="4.71162" /score="18.4600501" /energy="-12" /TU="NA" /idTUdmin="U111" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 178161..178166 /Source="Nicolas_upshift_promotors" /id="U112" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.653346653346653" /psig="0.707292707292707" /xcortree=1448 /SigmaFactorBS="aatgagatctgggcttttttatatAACATAcacttaagcagc ATTGATATAATAGAGAGAAGagaaattttaaataggggacttgcatatgatgcttcag a" /listShort="ybaS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 178179..178198 /Source="Nicolas_upshift_promotors" /id="U112" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.653346653346653" /psig="0.707292707292707" /xcortree=1448 /SigmaFactorBS="aatgagatctgggcttttttatatAACATAcacttaagcagc ATTGATATAATAGAGAGAAGagaaattttaaataggggacttgcatatgatgcttcag a" /listShort="ybaS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 178197 /Source="Nicolas_upshifts" /id="U112" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.653346653346653" /psig="0.707292707292707" /xcortree=1448 /SigmaFactorBS="aatgagatctgggcttttttatatAACATAcacttaagcagc ATTGATATAATAGAGAGAAGagaaattttaaataggggacttgcatatgatgcttcag a" /listShort="ybaS" /GFF_Attribute="listLong" /label="upshifts" CDS 178264..179184 /gene="ybaS" /locus_tag="BSU_01590" /old_locus_tag="BSU01590" /function="7: Transport and binding proteins" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sodium dependent transporter" /protein_id="NP_388040.2" /db_xref="EnsemblGenomes-Gn:BSU01590" /db_xref="EnsemblGenomes-Tr:CAB11935" /db_xref="GOA:P55190" /db_xref="InterPro:IPR002657" /db_xref="InterPro:IPR004710" /db_xref="SubtiList:BG11563" /db_xref="UniProtKB/Swiss-Prot:P55190" /translation="MPLLTPTSVVLGVLLSQFLNGYEWAVPWIFAFITFAGSLSANFQ SLRHALSHPLPMILALFVLHIFMPLFAWGSGHLIFKGDPLTITGLTLAVVIPTGITSL IWAAMYKGNVGLTLSIILVDTVLSPLIVPLSLSLLAGAQVHMDVWGMMKGLIVMVVIP SFLGMLFNQMSSPERTAFVSSALSPFSKLCLMAVIAINSSAIAPYFKSIDLRFAGIAV TVFFIALTGYAAAWLIGKMMKRRQEEIVSLIFTGGMRNISAGAVLAVTFFPSQVAVPV VIGMLFQQILAALFGYMLNRFELKPMLQKA*" /label="ybaS CDS" gene 178264..179184 /gene="ybaS" /locus_tag="BSU_01590" /old_locus_tag="BSU01590" /label="ybaS gene" downshifts 179165 /Source="Nicolas_upshifts" /id="D57" /incds=0 /nref=33 /ntot=224 /MaxReadThrough="1.3063" /MaxDrop="3.58628" /score="13.3102824" /energy="-10.5" /TU="NA" /idTUdmin="U112" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(179194..179946) /gene="eesA" /locus_tag="BSU_01600" /old_locus_tag="BSU01600" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 2974033, 17725565, 22210890, 28283524" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 2974033, 17725565, 22210890, 28283524; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="iron-chelator (enterobactin family) esterase" /protein_id="NP_388041.2" /db_xref="EnsemblGenomes-Gn:BSU01600" /db_xref="EnsemblGenomes-Tr:CAB11936" /db_xref="GOA:P55192" /db_xref="InterPro:IPR000801" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG11565" /db_xref="UniProtKB/Swiss-Prot:P55192" /translation="MKGSLSEHKAGNRRFTLYLPPSYSTDSGGFPAVYVQDGSSLFQN QIELLESAFQQQRLPELVLIGIEPENRLDEYTPWPAASLSDRFTDFGGMGYHYLSDIT NQFIPLIEENWNVTREPQSRGMIGASLGGLISMFAILKYPSMFGKIGSISGSYWYENA AETIHISSLKPGTARVFMSIGSEEGREKQSIQRHMLKKTKQVHQSLKEKGFTEDQLCL SIEKGAVHHHKYFCKQFINALEWLYGKNRSTL*" /label="eesA CDS" gene complement(179194..179946) /gene="eesA" /locus_tag="BSU_01600" /old_locus_tag="BSU01600" /label="eesA gene" downshifts complement(179218) /Source="Nicolas_upshifts" /id="D58" /incds=0 /nref=15 /ntot=115 /MaxReadThrough="0.3819" /MaxDrop="4.57603" /score="25.9728338" /energy="-10.5" /TU="NA" /idTUdmin="U114" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(179943..180953) /gene="feuC" /locus_tag="BSU_01610" /old_locus_tag="BSU01610" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 2651410, 15849754, 16850406, 27375568; Product type t: transporter" /codon_start=1 /transl_table=11 /product="iron-uptake protein" /protein_id="NP_388042.2" /db_xref="EnsemblGenomes-Gn:BSU01610" /db_xref="EnsemblGenomes-Tr:CAB11937" /db_xref="GOA:P40411" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG10837" /db_xref="UniProtKB/Swiss-Prot:P40411" /translation="MAKKYALFIALILVVSYFSLTSGSFSVRPAELLSTLFQIDPNPQ YEILLFDLRLPRVVMAAIIGLGLGIAGAVIQAITRNGLADPGILGINAGAGAGIVAFM LLFQGQKEVTSIAAAMGMPLFGLIGGLIAAILIYIFAWHRGNLDSGRIILVGIAINSG FSALSLFLSLKMDPQDYQMAMVWKNGSIWSANWTYITAVLPWMLLFIPILIGKSRLLD TIRFDEDTVRSLGISSNKEKTILLVACVAIISACVSVAGSMAFVGLIAPHISRRLAGV EHRYILPLSGLIGMLLVISADFAGKLFFQPAEVPAGIILAILGVPYFLYLLFKQKKGE NA*" /label="feuC CDS" gene complement(179943..180953) /gene="feuC" /locus_tag="BSU_01610" /old_locus_tag="BSU01610" /label="feuC gene" CDS complement(180946..181950) /gene="feuB" /locus_tag="BSU_01620" /old_locus_tag="BSU01620" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2651410, 15849754, 16850406, 17725565; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ferri-bacillibactin permease" /protein_id="NP_388043.1" /db_xref="EnsemblGenomes-Gn:BSU01620" /db_xref="EnsemblGenomes-Tr:CAB11938" /db_xref="GOA:P40410" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG10836" /db_xref="UniProtKB/Swiss-Prot:P40410" /translation="MYSKQWTRIILITSPFAIALSLLLSILYGAKHLSTDIVFTSLIH FDPGNTDHQIIWHSRIPRAAGALLIGAALAVSGALMQGITRNYLASPSIMGVSDGSAF IITLCMVLLPQSSSIEMMIYSFIGSALGAVLVFGLAAMMPNGFTPVQLAIIGTVTSML LSSLSAAMSIYFQISQDLSFWYSARLHQMSPDFLKLAAPFFLIGIIMAISLSKKVTAV SLGDDISKSLGQKKKTIKIMAMLSVIILTGSAVALAGKIAFVGLVVPHITRFLVGSDY SRLIPCSCILGGIFLTLCDLASRFINYPFETPIEVVTSIIGVPFFLYLIKRKGGEQNG *" /label="feuB CDS" gene complement(180946..181950) /gene="feuB" /locus_tag="BSU_01620" /old_locus_tag="BSU01620" /label="feuB gene" CDS complement(181969..182922) /gene="feuA" /locus_tag="BSU_01630" /old_locus_tag="BSU01630" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8388528, 16889643, 17725565, 21802011, 22303020, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8388528, 16889643, 17725565, 21802011, 22303020, 25355936; Product type lp : lipoprotein" /codon_start=1 /transl_table=11 /product="ferri-bacillibactin-binding lipoprotein" /protein_id="NP_388044.1" /db_xref="EnsemblGenomes-Gn:BSU01630" /db_xref="EnsemblGenomes-Tr:CAB11939" /db_xref="GOA:P40409" /db_xref="InterPro:IPR002491" /db_xref="PDB:2PHZ" /db_xref="PDB:2WHY" /db_xref="PDB:2WI8" /db_xref="PDB:2XUZ" /db_xref="PDB:2XV1" /db_xref="SubtiList:BG10835" /db_xref="UniProtKB/Swiss-Prot:P40409" /translation="MKKISLTLLILLLALTAAACGSKNESTASKASGTASEKKKIEYL DKTYEVTVPTDKIAITGSVESMEDAKLLDVHPQGAISFSGKFPDMFKDITDKAEPTGE KMEPNIEKILEMKPDVILASTKFPEKTLQKISTAGTTIPVSHISSNWKENMMLLAQLT GKEKKAKKIIADYEQDLKEIKTKINDKAKDSKALVIRIRQGNIYIYPEQVYFNSTLYG DLGLKAPNEVKAAKAQELSSLEKLSEMNPDHIFVQFSDDENADKPDALKDLEKNPIWK SLKAVKEDHVYVNSVDPLAQGGTAWSKVRFLKAAAEKLTQN*" /label="feuA CDS" gene complement(181969..182922) /gene="feuA" /locus_tag="BSU_01630" /old_locus_tag="BSU01630" /label="feuA gene" promotor_-35 182282..182288 /Source="Nicolas_upshift_promotors" /id="U113" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=157 /SigmaFactorBS="gccttaaggcctaaatcaccgtatagtgtgGAGTTGAaatac acctgttcaGGGTAAATGTAAATGTTGCcttgtctgattctgatgacaagcgcttttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 182303..182321 /Source="Nicolas_upshift_promotors" /id="U113" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=157 /SigmaFactorBS="gccttaaggcctaaatcaccgtatagtgtgGAGTTGAaatac acctgttcaGGGTAAATGTAAATGTTGCcttgtctgattctgatgacaagcgcttttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 182312 /Source="Nicolas_upshifts" /id="U113" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=157 /SigmaFactorBS="gccttaaggcctaaatcaccgtatagtgtgGAGTTGAaatac acctgttcaGGGTAAATGTAAATGTTGCcttgtctgattctgatgacaagcgcttttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(182953..182972) /Source="Nicolas_upshift_promotors" /id="U114" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.984015984015984" /xcortree=2097 /SigmaFactorBS="gtccatgataaatcaggaatttgtccatggtgttatatctgt tcattcTCTATAATTCCAATTGATAAtagttatcaattgaacaggaggctctatagat g" /listShort="feuA, feuB, feuC, ybbA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(182960) /Source="Nicolas_upshifts" /id="U114" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.984015984015984" /xcortree=2097 /SigmaFactorBS="gtccatgataaatcaggaatttgtccatggtgttatatctgt tcattcTCTATAATTCCAATTGATAAtagttatcaattgaacaggaggctctatagat g" /listShort="feuA, feuB, feuC, ybbA" /GFF_Attribute="listLong" /label="upshifts" CDS complement(183013..184602) /gene="btr" /locus_tag="BSU_01640" /old_locus_tag="BSU01640" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16889643, 17725565, 17962296, 22210890" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16889643, 17725565, 17962296, 22210890; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional activator (AraC/XylS family) of synthesis and uptake of the siderophore bacillibactin" /protein_id="NP_388045.1" /db_xref="EnsemblGenomes-Gn:BSU01640" /db_xref="EnsemblGenomes-Tr:CAB11940" /db_xref="GOA:P40408" /db_xref="InterPro:IPR002491" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR018060" /db_xref="InterPro:IPR018062" /db_xref="InterPro:IPR020449" /db_xref="SubtiList:BG10834" /db_xref="UniProtKB/Swiss-Prot:P40408" /translation="MQNAVIYQPVQIEYLKKTSDLFSEQQLADSFVLIFHLKGNGYIS IGTNTNPLQKKTLYVCPPNETFGFTPAADGHIDACIIRLLSYIKETGQDIFTPCTESE LAKLKLMNVSHIENLAVRLQELAALWNESSQLSQLKCVIEVQSLIYDLFTASLSDQTD THSAIEKTKHYIETHADTKITLAQLSQMAGISAKHYSESFKKWTGQSVTEFITKTRIT KAKRLMAKSNCKLKEIAHQTGYQDEFYFSRIFKKYTGCSPTSYMKKRRKKIAAYGRGT MGHLIPLHHIPFAAALHPKWTSYYYQHYSTDIPVQLSAYRFNEKWEENLYTLSQAEPD VIVSMDSISPEEQDRLNRIAEVMYLPSEESWRTHFLQTASFLKEESEAEKWLADYDQQ TTAAKKTLQHVQGLRFLFLRLHKQNFYLAHNRSVREVFFGDLGFSSATTADTPSEQAI SLENIANYQADCMMLFLFKEPETIAYYQQLQQTEAWQNLSAVRDNRVYLLSLDPWNEY SACGHERIVQQTVSLLSGDCP*" /label="btr CDS" gene complement(183013..184602) /gene="btr" /locus_tag="BSU_01640" /old_locus_tag="BSU01640" /label="btr gene" promotor_-10 complement(184643..184662) /Source="Nicolas_upshift_promotors" /id="U115" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.506493506493506" /psig=1 /xcortree=2112 /SigmaFactorBS="tttttttcatgctaaaaacccacccgctttaTATAGGAAaac tttcatttattTGGTACAATTTTTATTGAAAatgattatcaattgaaagcttctgaaa a" /listShort="ybbB, feuA, feuB, feuC, ybbA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(184655) /Source="Nicolas_upshifts" /id="U115" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.506493506493506" /psig=1 /xcortree=2112 /SigmaFactorBS="tttttttcatgctaaaaacccacccgctttaTATAGGAAaac tttcatttattTGGTACAATTTTTATTGAAAatgattatcaattgaaagcttctgaaa a" /listShort="ybbB, feuA, feuB, feuC, ybbA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(184677..184684) /Source="Nicolas_upshift_promotors" /id="U115" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.506493506493506" /psig=1 /xcortree=2112 /SigmaFactorBS="tttttttcatgctaaaaacccacccgctttaTATAGGAAaac tttcatttattTGGTACAATTTTTATTGAAAatgattatcaattgaaagcttctgaaa a" /listShort="ybbB, feuA, feuB, feuC, ybbA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(184764) /Source="Nicolas_upshifts" /id="D59" /incds=0 /nref=19 /ntot=58 /MaxReadThrough="1.28464" /MaxDrop="7.13916" /score="9.64466628" /energy="-10.1" /TU="NA" /idTUdmin="U116" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(184793..186037) /gene="ybbC" /locus_tag="BSU_01650" /old_locus_tag="BSU01650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388046.1" /db_xref="EnsemblGenomes-Gn:BSU01650" /db_xref="EnsemblGenomes-Tr:CAB11941" /db_xref="InterPro:IPR008302" /db_xref="SubtiList:BG10833" /db_xref="UniProtKB/Swiss-Prot:P40407" /translation="MRKTIFAFLTGLMMFGTITAASASPDSKNQTAKKPKVQTGIDTL LPDYKKQLKGKRIGLITNPAGVNTSLKSSVDILYENPDIKLTALFGPEHGVRGDAQAG DEVGSYIDEKTGVPVYSLYGKTKKPTPEMLKNVDILMFDIQDVGTRFYTYIYTMAYAM EAAKENGIPFMVLDRPNPQGGNHIEGPILEPEYASFVGLYPIPLKHGMTIGELASLFN KEFSIDADLTVVKMKHWKRKMDFDDTRLPFVLPSPNMPTVESTFVYPATGLIEGTNIS EGRGTTKPFELIGAPFIKSTELEETLNSLHLPGVTFRAASFTPTFSKHQGTLCHGVQL YVTDRDKFEAVKTGLSVIKTIHDLYPEDFEFLSTGSFDKLAGNGWIRTKIENGTSVEN IINSYEKTLQQFSKTRKKYLIY*" /label="ybbC CDS" gene complement(184793..186037) /gene="ybbC" /locus_tag="BSU_01650" /old_locus_tag="BSU01650" /label="ybbC gene" downshifts complement(184814) /Source="Nicolas_upshifts" /id="D60" /incds=0 /nref=11 /ntot=122 /MaxReadThrough="7.66074" /MaxDrop="4.10379" /score="9.64466628" /energy="-10.1" /TU="U116" /idTUdmin="U116" /TUdmin="-50" /isTUend="FALSE" /label="downshifts" CDS complement(186051..187979) /gene="nagZ" /locus_tag="BSU_01660" /old_locus_tag="BSU01660" /EC_number="3.2.1.52" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8063094, 20400549, 20826810, 23177201, 26963691" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8063094, 20400549, 20826810, 23177201, 26963691; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylglucosaminidase lipoprotein" /protein_id="NP_388047.1" /db_xref="EnsemblGenomes-Gn:BSU01660" /db_xref="EnsemblGenomes-Tr:CAB11942" /db_xref="GOA:P40406" /db_xref="InterPro:IPR001764" /db_xref="InterPro:IPR002772" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR019800" /db_xref="InterPro:IPR036881" /db_xref="InterPro:IPR036962" /db_xref="PDB:3BMX" /db_xref="PDB:3LK6" /db_xref="PDB:3NVD" /db_xref="PDB:4GYJ" /db_xref="PDB:4GYK" /db_xref="SubtiList:BG10832" /db_xref="UniProtKB/Swiss-Prot:P40406" /translation="MRPVFPLILSAVLFLSCFFGARQTEASASKRAIDANQIVNRMSL DEKLGQMLMPDFRNWQKEGESSPQALTKMNDEVASLVKKYQFGGIILFAENVKTTKQT VQLTDDYQKASPKIPLMLSIDQEGGIVTRLGEGTNFPGNMALGAARSRINAYQTGSII GKELSALGINTDFSPVVDINNNPDNPVIGVRSFSSNRELTSRLGLYTMKGLQRQDIAS ALKHFPGHGDTDVDSHYGLPLVSHGQERLREVELYPFQKAIDAGADMVMTAHVQFPAF DDTTYKSKLDGSDILVPATLSKKVMTGLLRQEMGFNGVIVTDALNMKAIADHFGQEEA VVMAVKAGVDIALMPASVTSLKEEQKFARVIQALKEAVKNGDIPEQQINNSVERIISL KIKRGMYPARNSDSTKEKIAKAKKIVGSKQHLKAEKKLAEKAVTVLKNEQHTLPFKPK KGSRILIVAPYEEQTASIEQTIHDLIKRKKIKPVSLSKMNFASQVFKTEHEKQVKEAD YIITGSYVVKNDPVVNDGVIDDTISDSSKWATVFPRAVMKAALQHNKPFVLMSLRNPY DAANFEEAKALIAVYGFKGYANGRYLQPNIPAGVMAIFGQAKPKGTLPVDIPSVTKPG NTLYPLGYGLNIKTGRPL*" /label="nagZ CDS" gene complement(186051..187979) /gene="nagZ" /locus_tag="BSU_01660" /old_locus_tag="BSU01660" /label="nagZ gene" CDS complement(188007..189332) /gene="amiE" /locus_tag="BSU_01670" /old_locus_tag="BSU01670" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16452451, 20400549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16452451, 20400549; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="amidase hydrolyzing N-acetylmuramyl-L-Ala bond of MurNAc peptides" /protein_id="NP_388048.2" /db_xref="EnsemblGenomes-Gn:BSU01670" /db_xref="EnsemblGenomes-Tr:CAB11943" /db_xref="InterPro:IPR001466" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR022849" /db_xref="SubtiList:BG11566" /db_xref="UniProtKB/Swiss-Prot:O05213" /translation="MKTKTLFIFSAILTLSIFAPNETFAQTAGNLIEPKIINAETAQF STKKLRKVDQMIERDIAAGFPGAVLVVVKDGRIIKKAAYGYSKKYEGSELLRRPAKMK TRTMFDLASNTKMYATNFALQRLVSQGKLDVYEKVSAYLPGFKDQPGDLIKGKDKIRV IDVLQHQSGLPSSFYFYTPEKAGKYYSQERDKTIEYLTKIPLDYQTGTKHVYSDIGYM LLGCIVEKLTGKPLDVYTEQELYKPLRLKHTLYNPLQKGFKPKQFAATERMGNTRDGV IQFPNIRTNTLQGEVHDEKAFYSMDGVSGHAGLFSNADDMAILLQVMLNKGSYRNISL FDQKTADLFTAPSATDPTFALGWRRNGSKSMEWMFGPHASENAYGHTGWTGTVTIIDP AYNLGIALLTNKKHTPVIDPEENPNVFEGDQFPTGSYGSVITAIYEAME*" /label="amiE CDS" gene complement(188007..189332) /gene="amiE" /locus_tag="BSU_01670" /old_locus_tag="BSU01670" /label="amiE gene" CDS complement(189389..190756) /gene="murP" /locus_tag="BSU_01680" /old_locus_tag="BSU01680" /EC_number="2.7.1.192" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15060041, 15849754, 16850406, 10627040, 20400549, 22960854; Product type t : transporter" /codon_start=1 /transl_table=11 /product="N-acetylmuramic acid PTS permease-MurP subunit" /protein_id="NP_388049.3" /db_xref="EnsemblGenomes-Gn:BSU01680" /db_xref="EnsemblGenomes-Tr:CAB11944" /db_xref="GOA:Q797S1" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG11567" /db_xref="UniProtKB/Swiss-Prot:Q797S1" /translation="MSKENNYHHLAQKILELCGGKSNISSYTHCMTRLRITPYDESKA DAQALRKLDGVLGVVEAETLQIILGTGVVNHVTAAFSKLVSAEEGADVKEAAAKKKAD INRKNATPFKLFLRKIASIFIPLIPALVASGLITGITKAIIQAGWLSADSQIAIILTV IGSGLFTYLGILVGINASKEFGGTPALGALAGILIINPEIAKISLFGEELLPGRGGLI GVLFAAIFIAYTEQFIRRFIPQSLDIIVTPTVSLLITGIVTYVVFMPLGGFISDAITS GLLSILDIGGIAAGFILGATFLPLVVTGLHQGLTPVHMELINSIGNDPLLPILAMGGA GQVGAAFAVFVKTKKTTLRKAIAGGLPSGLLGIGEPLIFGVTLPLGRPFLTACLGAGI GGAFQAYFQVATIAIGVSGLPLSFLVLPSQIILYIVGLFISYAAGFLLTYAFGYKDEM ASQFD*" /label="murP CDS" gene complement(189389..190756) /gene="murP" /locus_tag="BSU_01680" /old_locus_tag="BSU01680" /label="murP gene" CDS complement(190782..191633) /gene="murR" /locus_tag="BSU_01690" /old_locus_tag="BSU01690" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 20400549; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator MurR-N-acetylmuramic acid" /protein_id="NP_388050.1" /db_xref="EnsemblGenomes-Gn:BSU01690" /db_xref="EnsemblGenomes-Tr:CAB11945" /db_xref="GOA:Q45581" /db_xref="InterPro:IPR000281" /db_xref="InterPro:IPR001347" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR035472" /db_xref="InterPro:IPR036388" /db_xref="PDB:2O3F" /db_xref="SubtiList:BG11569" /db_xref="UniProtKB/Swiss-Prot:Q45581" /translation="MATGGLAIIQSMKHKLPPSERKLADYILAHPHKAIESTVNEISA LANSSDAAVIRLCKSLGLKGFQDLKMRVAGDLAKPTFQGYRDIVPHEPLPSISEKTAG NAIQAIQDTSDLMDYKELERAVSLLLKAHTVHFIGLGASGIVAKDAQQKWLRIHKQAT AFTDTHLVASLIANADKDDIVFAISFSGETQEIVELFAMAKEKGITTISLTQFSQTSV SALADVPLYTAHSNEALIRSAATSSRLAQLFIIDVLFLGMAAEQYETTTGYIDKTRAA IQSMRIK*" /label="murR CDS" gene complement(190782..191633) /gene="murR" /locus_tag="BSU_01690" /old_locus_tag="BSU01690" /label="murR gene" CDS complement(191650..192564) /gene="murQ" /locus_tag="BSU_01700" /old_locus_tag="BSU01700" /EC_number="4.2.1.126" /function="16.13: Shape" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15983044, 20400549, 16452451; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-lactyl ether N-acetylmuramic-6-phosphate acid etherase" /protein_id="NP_388051.1" /db_xref="EnsemblGenomes-Gn:BSU01700" /db_xref="EnsemblGenomes-Tr:CAB11946" /db_xref="GOA:Q45582" /db_xref="InterPro:IPR001347" /db_xref="InterPro:IPR005486" /db_xref="InterPro:IPR005488" /db_xref="SubtiList:BG11570" /db_xref="UniProtKB/Swiss-Prot:Q45582" /translation="MSEPLNLHRLTTESRNSQTVEIHKANTLGILKMINNEDMKVAAA VQEVLPDIKTAVDCAYESFQNGGRLIYTGAGTSGRLGVMDAVECPPTYSVSPDQVIGI MAGGPEAFLQAAEGIEDSEEAGAEDLRNIQLTSNDTVIAIAASGRTPYAAGALRYARK VGAHTIALTCNENSAISKDADHSIEVVVGPEAITGSTRMKAATAHKMILNMISTAVMV KIGKVYENLMVDVNVSNKKLKERAISIIQSLTNASYDTARYTLEQADHHVKTAIVMLK TSTDQKQAQTLLDEANGFIDKAIEHYHP*" /label="murQ CDS" gene complement(191650..192564) /gene="murQ" /locus_tag="BSU_01700" /old_locus_tag="BSU01700" /label="murQ gene" promotor_-10 complement(192595..192613) /Source="Nicolas_upshift_promotors" /id="U116" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.25974025974026" /psig="0.681318681318681" /xcortree=765 /SigmaFactorBS="agtgaaataaaatttcaaaaatttaaaaacatAGTTGAAAta tcataacagaaatGAATATACTGAATATTGAGatatatcattttaaaacagggggcat c" /listShort="murQ, ybbH, ybbF, ybbE, ybbD, ybbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(192608) /Source="Nicolas_upshifts" /id="U116" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.25974025974026" /psig="0.681318681318681" /xcortree=765 /SigmaFactorBS="agtgaaataaaatttcaaaaatttaaaaacatAGTTGAAAta tcataacagaaatGAATATACTGAATATTGAGatatatcattttaaaacagggggcat c" /listShort="murQ, ybbH, ybbF, ybbE, ybbD, ybbC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(192629..192636) /Source="Nicolas_upshift_promotors" /id="U116" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.25974025974026" /psig="0.681318681318681" /xcortree=765 /SigmaFactorBS="agtgaaataaaatttcaaaaatttaaaaacatAGTTGAAAta tcataacagaaatGAATATACTGAATATTGAGatatatcattttaaaacagggggcat c" /listShort="murQ, ybbH, ybbF, ybbE, ybbD, ybbC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(192674..193156) /gene="ybbJ" /locus_tag="BSU_01710" /old_locus_tag="BSU01710" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyltransferase" /protein_id="NP_388052.2" /db_xref="EnsemblGenomes-Gn:BSU01710" /db_xref="EnsemblGenomes-Tr:CAB11947" /db_xref="GOA:Q45583" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11571" /db_xref="UniProtKB/Swiss-Prot:Q45583" /translation="MTQDISLSFYKPEHLPELQSFTLTNDDKRFTSLPKEVLSQALGI QDRYPVVILKDDLPVGFFILHASKETLASYSNNPFALLLSSLSLTAVHHGKGYAKKAM LLLPAFVSGYFPWCDEIILAVNHLNIRAKHLYMKSGFLDKGRRRIGPLGEQLILHHFL *" /label="ybbJ CDS" gene complement(192674..193156) /gene="ybbJ" /locus_tag="BSU_01710" /old_locus_tag="BSU01710" /label="ybbJ gene" CDS complement(193169..193624) /gene="ybbK" /locus_tag="BSU_01720" /old_locus_tag="BSU01720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388053.2" /db_xref="EnsemblGenomes-Gn:BSU01720" /db_xref="EnsemblGenomes-Tr:CAB11948" /db_xref="InterPro:IPR007553" /db_xref="SubtiList:BG11572" /db_xref="UniProtKB/Swiss-Prot:Q45584" /translation="MILVSSCLGGIECRYNGSHAASEKIRKLVDEKKAVMACPELLGG FSTPREPAEIIGGTGEDVLNGTAKIVTASGEDVTELYMEGAAKTLAYAKEINASAVIL KENSPSCGSGFIYNGTFSGKKITGSGVTAALLKQAGYRVISENELNDIL*" /label="ybbK CDS" gene complement(193169..193624) /gene="ybbK" /locus_tag="BSU_01720" /old_locus_tag="BSU01720" /label="ybbK gene" promotor_-10 complement(193650..193669) /Source="Nicolas_upshift_promotors" /id="U117" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.7002997002997" /psig="0.992007992007992" /xcortree=3038 /SigmaFactorBS="ttttttattttcaaactttttaactccttttttaactgaaaa agccTCccaactaaagccatTTATTTTATGATAGAGACAAgcaaagcaagagaggaga a" /listShort="ybbK, ybbJ, murQ, ybbH, ybbF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(193671) /Source="Nicolas_upshifts" /id="U117" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.7002997002997" /psig="0.992007992007992" /xcortree=3038 /SigmaFactorBS="ttttttattttcaaactttttaactccttttttaactgaaaa agccTCccaactaaagccatTTATTTTATGATAGAGACAAgcaaagcaagagaggaga a" /listShort="ybbK, ybbJ, murQ, ybbH, ybbF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(193684..193685) /Source="Nicolas_upshift_promotors" /id="U117" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.7002997002997" /psig="0.992007992007992" /xcortree=3038 /SigmaFactorBS="ttttttattttcaaactttttaactccttttttaactgaaaa agccTCccaactaaagccatTTATTTTATGATAGAGACAAgcaaagcaagagaggaga a" /listShort="ybbK, ybbJ, murQ, ybbH, ybbF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 193744..193751 /Source="Nicolas_upshift_promotors" /id="U118" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.853146853146853" /psig=1 /xcortree=2416 /SigmaFactorBS="tttgaaaataaaaaatttaattttcctCTTTACAAacagggg gtgacctGTATATAATAACTTTTGTCAgctcgacgagaacacaacggcccgttggtca a" /listShort="trnSL-Glu2, trnSL-Val1, trnSL-Thr1, trnSL-Tyr1, trnSL-Gln2, S67" /listLong="sigW, rsiW, S68, ybbP, ybbR, glmM, NA, S69, glmS" /label="promotor_-35" promotor_-10 193766..193785 /Source="Nicolas_upshift_promotors" /id="U118" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.853146853146853" /psig=1 /xcortree=2416 /SigmaFactorBS="tttgaaaataaaaaatttaattttcctCTTTACAAacagggg gtgacctGTATATAATAACTTTTGTCAgctcgacgagaacacaacggcccgttggtca a" /listShort="trnSL-Glu2, trnSL-Val1, trnSL-Thr1, trnSL-Tyr1, trnSL-Gln2, S67" /listLong="sigW, rsiW, S68, ybbP, ybbR, glmM, NA, S69, glmS" /label="promotor_-10" upshifts 193777 /Source="Nicolas_upshifts" /id="U118" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.853146853146853" /psig=1 /xcortree=2416 /SigmaFactorBS="tttgaaaataaaaaatttaattttcctCTTTACAAacagggg gtgacctGTATATAATAACTTTTGTCAgctcgacgagaacacaacggcccgttggtca a" /listShort="trnSL-Glu2, trnSL-Val1, trnSL-Thr1, trnSL-Tyr1, trnSL-Gln2, S67" /listLong="sigW, rsiW, S68, ybbP, ybbR, glmM, NA, S69, glmS" /label="upshifts" tRNA 193804..193878 /gene="trnSL-Glu2" /locus_tag="BSU_tRNA_75" /product="tRNA-Glu" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Glu(UUC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Glu2 tRNA" gene 193804..193878 /gene="trnSL-Glu2" /locus_tag="BSU_tRNA_75" /label="trnSL-Glu2 gene" tRNA 193882..193957 /gene="trnSL-Val1" /locus_tag="BSU_tRNA_78" /product="tRNA-Val" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Val(UAC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Val1 tRNA" gene 193882..193957 /gene="trnSL-Val1" /locus_tag="BSU_tRNA_78" /label="trnSL-Val1 gene" tRNA 193962..194034 /gene="trnSL-Thr1" /locus_tag="BSU_tRNA_76" /product="tRNA-Thr" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Thr(UGU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Thr1 tRNA" gene 193962..194034 /gene="trnSL-Thr1" /locus_tag="BSU_tRNA_76" /label="trnSL-Thr1 gene" tRNA 194057..194141 /gene="trnSL-Tyr1" /locus_tag="BSU_tRNA_77" /product="tRNA-Tyr" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Tyr(GAU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Tyr1 tRNA" gene 194057..194141 /gene="trnSL-Tyr1" /locus_tag="BSU_tRNA_77" /label="trnSL-Tyr1 gene" tRNA 194146..194220 /gene="trnSL-Gln2" /locus_tag="BSU_tRNA_74" /product="tRNA-Gln" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gln(UUG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Gln2 tRNA" gene 194146..194220 /gene="trnSL-Gln2" /locus_tag="BSU_tRNA_74" /label="trnSL-Gln2 gene" downshifts 194223 /Source="Nicolas_upshifts" /id="D61" /incds=0 /nref=10 /ntot=91 /MaxReadThrough="4.25215" /MaxDrop="3.84626" /score="25.5087424" /energy="-11.4" /TU="U118" /idTUdmin="U118" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" S_feature 194268..194385 /Source="Nicolas_S_feature" /locus_tag="new_194669_194786" /HighExp="Paraq, BMM, H2O2, Heat, G180, G135, Oxctl, G150, C30, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S67" promotor_-35 194386..194395 /Source="Nicolas_upshift_promotors" /id="U119" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1680 /SigmaFactorBS="ttcacgaattaccatctacaccctgccaaaaatttgataaac ttattttataaaaaaatTGAAACCTTTtgaaacgaagcTCGTATACATACAGACcggt g" /listShort="sigW, rsiW" /listLong="S68, ybbP, ybbR, glmM, NA, S69, glmS" /label="promotor_-35" upshifts 194387 /Source="Nicolas_upshifts" /id="U119" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1680 /SigmaFactorBS="ttcacgaattaccatctacaccctgccaaaaatttgataaac ttattttataaaaaaatTGAAACCTTTtgaaacgaagcTCGTATACATACAGACcggt g" /listShort="sigW, rsiW" /listLong="S68, ybbP, ybbR, glmM, NA, S69, glmS" /label="upshifts" promotor_-10 194407..194422 /Source="Nicolas_upshift_promotors" /id="U119" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1680 /SigmaFactorBS="ttcacgaattaccatctacaccctgccaaaaatttgataaac ttattttataaaaaaatTGAAACCTTTtgaaacgaagcTCGTATACATACAGACcggt g" /listShort="sigW, rsiW" /listLong="S68, ybbP, ybbR, glmM, NA, S69, glmS" /label="promotor_-10" CDS 194448..195011 /gene="sigW" /locus_tag="BSU_01730" /old_locus_tag="BSU01730" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11866510, 15130127, 16629676, 21542858, 28319136, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11866510, 15130127, 16629676, 21542858, 28319136, 22720735; Product type r : regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase ECF(extracytoplasmic function)-type sigma factor W" /protein_id="NP_388054.1" /db_xref="EnsemblGenomes-Gn:BSU01730" /db_xref="EnsemblGenomes-Tr:CAB11949" /db_xref="GOA:Q45585" /db_xref="InterPro:IPR000838" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR014294" /db_xref="InterPro:IPR036388" /db_xref="PDB:5WUQ" /db_xref="PDB:5WUR" /db_xref="SubtiList:BG11573" /db_xref="UniProtKB/Swiss-Prot:Q45585" /translation="MEMMIKKRIKQVKKGDQDAFADIVDIYKDKIYQLCYRMLGNVHE AEDIAQEAFIRAYVNIDSFDINRKFSTWLYRIATNLTIDRIRKKKPDYYLDAEVAGTE GLTMYSQIVADGVLPEDAVVSLELSNTIQQKILKLPDKYRTVIVLKYIDELSLIEIGE ILNIPVGTVKTRIHRGREALRKQLRDL*" /label="sigW CDS" gene 194448..195011 /gene="sigW" /locus_tag="BSU_01730" /old_locus_tag="BSU01730" /label="sigW gene" CDS 195025..195651 /gene="rsiW" /locus_tag="BSU_01740" /old_locus_tag="BSU01740" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15130127, 28319136, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15130127, 28319136, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="anti-sigma(W) factor" /protein_id="NP_388055.1" /db_xref="EnsemblGenomes-Gn:BSU01740" /db_xref="EnsemblGenomes-Tr:CAB11950" /db_xref="GOA:Q45588" /db_xref="InterPro:IPR027383" /db_xref="PDB:5WUQ" /db_xref="PDB:5WUR" /db_xref="SubtiList:BG11574" /db_xref="UniProtKB/Swiss-Prot:Q45588" /translation="MSCPEQIVQLMHMHLDGDILPKDEHVLNEHLETCEKCRKHFYEM EKSIALVRSTSHVEAPADFTANVMAKLPKEKKRASVKRWFRTHPVIAAAAVFIILMGG GFFNSWHNDHNFSVSKQPNLVVHNHTVTVPEGETVKGDVTVKNGKLIIKGKIDGDVTV VNGEKYMASAGQVTGQIEEINQLFDWTWYKMKSAGKSVLDAFNPNGEE*" /label="rsiW CDS" gene 195025..195651 /gene="rsiW" /locus_tag="BSU_01740" /old_locus_tag="BSU01740" /label="rsiW gene" downshifts complement(195443) /Source="Nicolas_upshifts" /id="D62" /incds=1 /nref=2 /ntot=181 /MaxReadThrough="1.52124" /MaxDrop="3.24828" /score="0.305471631" /energy="-6.9" /TU="NA" /idTUdmin="U120" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_no_box complement(195601..195701) /Source="Nicolas_upshift_promotors" /id="U120" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95904095904096" /psig="0.002997002997003" /xcortree=56 /SigmaFactorBS="tgtgccagccctctcagcccgcaaaaaaagagcaaagcggct aacgcgctttactcttctccgttcggattgaatgcatcgagtacacttttccccgcag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" downshifts 195631 /Source="Nicolas_upshifts" /id="D63" /incds=0 /nref=251 /ntot=269 /MaxReadThrough="4.26924" /MaxDrop="8.34597" /score="7.39786279" /energy="-10.8" /TU="U119" /idTUdmin="U119" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" upshifts complement(195641) /Source="Nicolas_upshifts" /id="U120" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95904095904096" /psig="0.002997002997003" /xcortree=56 /SigmaFactorBS="tgtgccagccctctcagcccgcaaaaaaagagcaaagcggct aacgcgctttactcttctccgttcggattgaatgcatcgagtacacttttccccgcag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 195700..195707 /Source="Nicolas_upshift_promotors" /id="U121" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.73026973026973" /psig=1 /xcortree=1886 /SigmaFactorBS="tctttttttgcgggctgagagggctggcaCATTTCACttgct aaatcgaaaTGTGGTATAATGGGCTCGCTatgtaaagtacatatgcgtaacacgtaaa a" /listShort="S68, ybbP, ybbR, glmM" /listLong="NA, S69, glmS" /label="promotor_-35" promotor_-10 195722..195741 /Source="Nicolas_upshift_promotors" /id="U121" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.73026973026973" /psig=1 /xcortree=1886 /SigmaFactorBS="tctttttttgcgggctgagagggctggcaCATTTCACttgct aaatcgaaaTGTGGTATAATGGGCTCGCTatgtaaagtacatatgcgtaacacgtaaa a" /listShort="S68, ybbP, ybbR, glmM" /listLong="NA, S69, glmS" /label="promotor_-10" S_feature 195731..195811 /Source="Nicolas_S_feature" /locus_tag="new_196132_196212" /HighExp="dia5, Diami, H2O2, dia15, G135, Cold, G180, Paraq, G150, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigWXY, SigA" /TUlongPSig="1, 1" /label="S68" upshifts 195731 /Source="Nicolas_upshifts" /id="U121" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.73026973026973" /psig=1 /xcortree=1886 /SigmaFactorBS="tctttttttgcgggctgagagggctggcaCATTTCACttgct aaatcgaaaTGTGGTATAATGGGCTCGCTatgtaaagtacatatgcgtaacacgtaaa a" /listShort="S68, ybbP, ybbR, glmM" /listLong="NA, S69, glmS" /label="upshifts" CDS 195812..196633 /gene="cdaA" /locus_tag="BSU_01750" /old_locus_tag="BSU01750" /EC_number="2.7.7.85" /function="16.13: Shape" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:19901023, 21566650, 23192352, 25605729, 25616256, 26240071, 28420751" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19901023, 21566650, 23192352, 25605729, 25616256, 26240071, 28420751; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="diadenylate cyclase" /protein_id="NP_388056.2" /db_xref="EnsemblGenomes-Gn:BSU01750" /db_xref="EnsemblGenomes-Tr:CAB11951" /db_xref="GOA:Q45589" /db_xref="InterPro:IPR003390" /db_xref="InterPro:IPR014046" /db_xref="InterPro:IPR034701" /db_xref="InterPro:IPR036888" /db_xref="SubtiList:BG11577" /db_xref="UniProtKB/Swiss-Prot:Q45589" /translation="MAFEDIPFLQYLGNAVDILLVWYVIYKLIMVIRGTKAVQLLKGI VVIVLVRMASQYLGLSTLQWLMDQAITWGFLAIIIIFQPELRRALEQLGRGRFFSRSG TPVEEAQQKTIEAITKAINYMAKRRIGALLTIERDTGMGDYIETGIPLNAKVSSELLI NIFIPNTPLHDGAVIMKNNEIAAAACYLPLSESPFISKELGTRHRAAVGISEVTDSLT IIVSEETGGVSVAKNGDLHRELTEEALKEMLEAEFKKNTRDTSSNRWYWRGKKNG*" /label="cdaA CDS" gene 195812..196633 /gene="cdaA" /locus_tag="BSU_01750" /old_locus_tag="BSU01750" /label="cdaA gene" CDS 196626..198077 /gene="cdaR" /locus_tag="BSU_01760" /old_locus_tag="BSU01760" /experiment="publication(s) with functional evidences, PMID:16236721, 17406245, 20094656, 21154411, 22720735, 23192352, 27074767" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16236721, 17406245, 20094656, 21154411, 22720735, 23192352, 27074767; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of diadenylate cyclase activity" /protein_id="NP_388057.2" /db_xref="EnsemblGenomes-Gn:BSU01760" /db_xref="EnsemblGenomes-Tr:CAB11952" /db_xref="GOA:O34659" /db_xref="InterPro:IPR012505" /db_xref="InterPro:IPR015943" /db_xref="SubtiList:BG12703" /db_xref="UniProtKB/Swiss-Prot:O34659" /translation="MDKFLNNRWAVKIIALLFALLLYVAVNSNQAPTPKKPGESFFPT STTDEATLTDIPVKAYYDDENYVVTGVPQTVNVTIKGSTSAVKKARQTKNFEIYADME HLKTGTHKVELKAKNVSDGLTISINPSVTTVTIQERTTKSFPVEVEYYNKSKMKKGYS PEQPIVSPKNVQITGSKNVIDNISLVKASVNLENADETIEKEAKVTVYDKDGNALPVD VEPSVIKITVPVTSPSKKVPFKIERTGSLPDGVSIANIESSPSEVTVYGSQDVLDSLE FIDGVSLDLSKINKDSDIEADIPLPDGVKKISPSKVTLHIEVDSEADQKFENVPIKTV GLSSSQNIEFLDPESQAIDVTAKGSPTNINKLKKSDIELYVNVSDLEDGEHSVKLEVN GPQNVTWSLGRKNAKIKLTSKKSNTSTNDNSSNTSGNQDTDKQTNDQKNNQQEDTKNT DKNNNDQNQDGNKDQNQDQDEDESTANSQSSSE*" /label="cdaR CDS" gene 196626..198077 /gene="cdaR" /locus_tag="BSU_01760" /old_locus_tag="BSU01760" /label="cdaR gene" CDS 198096..199442 /gene="glmM" /locus_tag="BSU_01770" /old_locus_tag="BSU01770" /EC_number="5.4.2.10" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10671448, 10913078, 12089032, 21154411, 26240071, 27074767" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10671448, 10913078, 12089032, 21154411, 26240071, 27074767; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="phosphoglucosamine mutase" /protein_id="NP_388058.1" /db_xref="EnsemblGenomes-Gn:BSU01770" /db_xref="EnsemblGenomes-Tr:CAB11953" /db_xref="GOA:O34824" /db_xref="InterPro:IPR005841" /db_xref="InterPro:IPR005843" /db_xref="InterPro:IPR005844" /db_xref="InterPro:IPR005845" /db_xref="InterPro:IPR005846" /db_xref="InterPro:IPR006352" /db_xref="InterPro:IPR016055" /db_xref="InterPro:IPR016066" /db_xref="InterPro:IPR036900" /db_xref="SubtiList:BG12704" /db_xref="UniProtKB/Swiss-Prot:O34824" /translation="MGKYFGTDGVRGVANSELTPELAFKVGRFGGYVLTKDKQRPKVL IGRDTRISGHMLEGALVAGLLSIGAEVMRLGVISTPGVSYLTKAMDAEAGVMISASHN PVQDNGIKFFGGDGFKLSDEQEAEIERLMDEPEDKLPRPVGADLGLVNDYFEGGQKYL QFLKQTADEDFTGIHVALDCANGATSSLATHLFADLDADVSTMGTSPNGLNINDGVGS THPEALSAFVKEKNADLGLAFDGDGDRLIAVDEKGNIVDGDQIMYICSKHLKSEGRLK DDTVVSTVMSNLGFYKALEKEGIKSVQTAVGDRYVVEAMKKDGYNVGGEQSGHLIFLD YNTTGDGLLSAIMLMNTLKATGKPLSELAAEMQKFPQLLVNVRVTDKYKVEENEKVKA VISEVEKEMNGDGRILVRPSGTEPLVRVMAEAKTKELCDEYVNRIVEVVRSEMGLE*" /label="glmM CDS" gene 198096..199442 /gene="glmM" /locus_tag="BSU_01770" /old_locus_tag="BSU01770" /label="glmM gene" downshifts 199437 /Source="Nicolas_upshifts" /id="D64" /incds=0 /nref=126 /ntot=216 /MaxReadThrough="5.32721" /MaxDrop="5.02497" /score="13.5044076" /energy="-17.5" /TU="U121" /idTUdmin="U121" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" promotor_-35 199461..199469 /Source="Nicolas_upshift_promotors" /id="U122" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.754245754245754" /psig="0.754245754245754" /xcortree=649 /SigmaFactorBS="tccggtcagaaatgggattagagtaacgaagtctattatcag agAGTGAACAAgacaagcgaggttTACATAAGATAATTGTGAGAcatacggcaaagtt g" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 199477 /Source="Nicolas_upshifts" /id="U122" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.754245754245754" /psig="0.754245754245754" /xcortree=649 /SigmaFactorBS="tccggtcagaaatgggattagagtaacgaagtctattatcag agAGTGAACAAgacaagcgaggttTACATAAGATAATTGTGAGAcatacggcaaagtt g" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 199483..199502 /Source="Nicolas_upshift_promotors" /id="U122" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.754245754245754" /psig="0.754245754245754" /xcortree=649 /SigmaFactorBS="tccggtcagaaatgggattagagtaacgaagtctattatcag agAGTGAACAAgacaagcgaggttTACATAAGATAATTGTGAGAcatacggcaaagtt g" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 199529..199534 /Source="Nicolas_upshift_promotors" /id="U123" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.623376623376623" /psig="0.999000999001" /xcortree=1722 /SigmaFactorBS="tgtgagacatacggcaaagttgcttaaaaaacaATTGACcgt ttatgccacatgTTGTAAAATCAAGCTTGTCTtgttcttattttctcaataggaaaag a" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 199550..199569 /Source="Nicolas_upshift_promotors" /id="U123" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.623376623376623" /psig="0.999000999001" /xcortree=1722 /SigmaFactorBS="tgtgagacatacggcaaagttgcttaaaaaacaATTGACcgt ttatgccacatgTTGTAAAATCAAGCTTGTCTtgttcttattttctcaataggaaaag a" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 199556 /Source="Nicolas_upshifts" /id="U123" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.623376623376623" /psig="0.999000999001" /xcortree=1722 /SigmaFactorBS="tgtgagacatacggcaaagttgcttaaaaaacaATTGACcgt ttatgccacatgTTGTAAAATCAAGCTTGTCTtgttcttattttctcaataggaaaag a" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="upshifts" misc_feature 199600..199616 /Source="Nicolas_upshift_promotors" /id="U124" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=336 /SigmaFactorBS="taaaatcaagcttgtcttgttcttattttctcaataggaaaa gaagaCGGGATTATTGCTTTACctataattatagcgcccgaactaagcgcccggaaaa a" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 199613 /Source="Nicolas_upshifts" /id="U124" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=336 /SigmaFactorBS="taaaatcaagcttgtcttgttcttattttctcaataggaaaa gaagaCGGGATTATTGCTTTACctataattatagcgcccgaactaagcgcccggaaaa a" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 199616..199786 /gene="glmSA" /locus_tag="BSU_misc_RNA_5" /product="riboswitch and ribozyme (GlmS-glucosamine-6-P)" /experiment="publication(s) with functional evidences, PMID:16298301, 16484375, 16990543, 17114942, 17283212, 18079181, 19228039, 21317896, 21395279, 21936556, 25038539, 26240071, 28012261" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16298301, 16484375, 16990543, 17114942, 17283212, 18079181, 19228039, 21317896, 21395279, 21936556, 25038539, 26240071, 28012261; Product type n: RNA" /label="glmSA RNA" gene 199616..199786 /gene="glmSA" /locus_tag="BSU_misc_RNA_5" /label="glmSA gene" S_feature 199787..199875 /Source="Nicolas_S_feature" /locus_tag="new_200188_200276" /HighExp="M40t90, M0t90, M9-stat, Lbstat, T2.30H, T2.0H, T3.0H, T1.30H, T1.0H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigK" /TUshortPSig="0.498, 0.999, 0.754" /TUlongSig="SigA, SigWXY, SigA" /TUlongPSig="1, 1, 1" /label="S69" CDS 199876..201678 /gene="glmS" /locus_tag="BSU_01780" /old_locus_tag="BSU01780" /EC_number="2.6.1.16" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 15029187, 17114942, 17283212, 17322533, 23874669; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="L-glutamine-D-fructose-6-phosphate amidotransferase" /protein_id="NP_388059.1" /db_xref="EnsemblGenomes-Gn:BSU01780" /db_xref="EnsemblGenomes-Tr:CAB11954" /db_xref="GOA:P0CI73" /db_xref="InterPro:IPR001347" /db_xref="InterPro:IPR005855" /db_xref="InterPro:IPR017932" /db_xref="InterPro:IPR029055" /db_xref="InterPro:IPR035466" /db_xref="InterPro:IPR035490" /db_xref="SubtiList:BG10948" /db_xref="UniProtKB/Swiss-Prot:P0CI73" /translation="MCGIVGYIGQLDAKEILLKGLEKLEYRGYDSAGIAVANEQGIHV FKEKGRIADLREVVDANVEAKAGIGHTRWATHGEPSYLNAHPHQSALGRFTLVHNGVI ENYVQLKQEYLQDVELKSDTDTEVVVQVIEQFVNGGLETEEAFRKTLTLLKGSYAIAL FDNDNRETIFVAKNKSPLLVGLGDTFNVVASDAMAMLQVTNEYVELMDKEMVIVTDDQ VVIKNLDGDVITRASYIAELDASDIEKGTYPHYMLKETDEQPVVMRKIIQTYQDENGK LSVPGDIAAAVAEADRIYIIGCGTSYHAGLVGKQYIEMWANVPVEVHVASEFSYNMPL LSKKPLFIFLSQSGETADSRAVLVQVKALGHKALTITNVPGSTLSREADYTLLLHAGP EIAVASTKAYTAQIAVLAVLASVAADKNGINIGFDLVKELGIAANAMEALCDQKDEME MIAREYLTVSRNAFFIGRGLDYFVCVEGALKLKEISYIQAEGFAGGELKHGTIALIEQ GTPVFALATQEHVNLSIRGNVKEVAARGANTCIISLKGLDDADDRFVLPEVNPALAPL VSVVPLQLIAYYAALHRGCDVDKPRNLAKSVTVE*" /label="glmS CDS" gene 199876..201678 /gene="glmS" /locus_tag="BSU_01780" /old_locus_tag="BSU01780" /label="glmS gene" S_feature complement(201401..>201681) /Source="Nicolas_S_feature" /locus_tag="new_201802_202546_c" /HighExp="S8, S7, S6, S5, S4, BC, S3, Sw, C30, LoTm" /AntisenseName="glmS" /AntisenseCor="4.5056549205256403E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.963" /TUlongSig="NA" /TUlongPSig="NA" /label="S70" downshifts 201664 /Source="Nicolas_upshifts" /id="D65" /incds=0 /nref=260 /ntot=277 /MaxReadThrough="3.18134" /MaxDrop="7.61794" /score="13.5044076" /energy="-17.5" /TU="NA" /idTUdmin="U122" /TUdmin=2 /isTUend="TRUE" /label="downshifts" SCAR join(201681,201727) /created_by="User" /note="deletion occured in betwen marked nucleotides" /modified_by="User" /label="Delta4" N_region 201682..201726 /note="insertion of 45 bases of unknown origin" /modified_by="User" /label="Delta4" S_feature <201727..201845 /Source="Nicolas_S_feature" /locus_tag="new_220105_220278" /HighExp="LoTm, T5.0H, T4.0H, T3.30H, Pyr, T-2.40H, T3.0H, T-5.40H, S2, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.984" /TUlongSig="NA" /TUlongPSig="NA" /label="S79" CDS 201846..202823 /gene="ybdG" /locus_tag="BSU_01990" /old_locus_tag="BSU01990" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase/transferase" /protein_id="NP_388081.2" /db_xref="EnsemblGenomes-Gn:BSU01990" /db_xref="EnsemblGenomes-Tr:CAB11993" /db_xref="GOA:O31431" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12722" /db_xref="UniProtKB/Swiss-Prot:O31431" /translation="MKTLWKVLKIVFVSLAALVLLVSVSVFIYHHFQLNKEAALLKGK GTVVDVDGKKMNVYQEGSGKDTFVFMSGSGIAAPAYEMKGLYSKFSKENKIAVVDRAG YGYSEVSHDDRDIDTVLEQTRKALMKSGNKPPYILMPHSISGIEAMYWAQKYPKEIKA IIAMDIGLPQQYVTYKLSGVDRLKVRGFHLLTSIGFHRFIPSAVYNPEVIRQSFLTDE EKEIYKAINFKQFFNADMEHELLQSYQNGSKSVNLPAPKETPVLILDAVSDQNRHSKY AIQNRKDYEAFAAQFNTADIKELRGTHSIYLYQPDQIYKLSMEFMRKVR*" /label="ybdG CDS" gene 201846..202823 /gene="ybdG" /locus_tag="BSU_01990" /old_locus_tag="BSU01990" /label="ybdG gene" CDS 202825..203496 /gene="ybdJ" /locus_tag="BSU_02000" /old_locus_tag="BSU02000" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 20035725" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 20035725; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component system response regulator [YbdK]" /protein_id="NP_388082.1" /db_xref="EnsemblGenomes-Gn:BSU02000" /db_xref="EnsemblGenomes-Tr:CAB11994" /db_xref="GOA:O31432" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12723" /db_xref="UniProtKB/Swiss-Prot:O31432" /translation="MKGYRILIVEDDVMIGDLLQKILQREGYRVIWKTDGADVLSVIQ KVDLVIMDVMLPGEDGYQMSAKIKKLGLGIPVIFLSARNDMDSKLQGLQIGEDYMVKP FDPRELLLRMRNMLEHHYGTFTQIKHLYIDAVTKKVFNESLHDEVLFTAIERKIFFYL YENRDSILTKEHFFEYLWQLEDRNPNIVNVHIKKIRAKINDQAGEMIENIYGEGYRLN TVVKK*" /label="ybdJ CDS" gene 202825..203496 /gene="ybdJ" /locus_tag="BSU_02000" /old_locus_tag="BSU02000" /label="ybdJ gene" promotor_-35 203390..203396 /Source="Nicolas_upshift_promotors" /id="U135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.929070929070929" /xcortree=2962 /SigmaFactorBS="gatagaaacccgaatattgtcaATGTGCAtattaaaaaaatt AGAGCTAAAATCAATGATCAagcgggtgagatgattgaaaatatatatggagaagggt a" /listShort="ybdK, ybzI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 203410..203429 /Source="Nicolas_upshift_promotors" /id="U135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.929070929070929" /xcortree=2962 /SigmaFactorBS="gatagaaacccgaatattgtcaATGTGCAtattaaaaaaatt AGAGCTAAAATCAATGATCAagcgggtgagatgattgaaaatatatatggagaagggt a" /listShort="ybdK, ybzI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 203428 /Source="Nicolas_upshifts" /id="U135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.929070929070929" /xcortree=2962 /SigmaFactorBS="gatagaaacccgaatattgtcaATGTGCAtattaaaaaaatt AGAGCTAAAATCAATGATCAagcgggtgagatgattgaaaatatatatggagaagggt a" /listShort="ybdK, ybzI" /GFF_Attribute="listLong" /label="upshifts" CDS 203517..204479 /gene="ybdK" /locus_tag="BSU_02010" /old_locus_tag="BSU02010" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 20035725" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 20035725; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component system sensor histidine kinase [YbdJ]" /protein_id="NP_388083.1" /db_xref="EnsemblGenomes-Gn:BSU02010" /db_xref="EnsemblGenomes-Tr:CAB11995" /db_xref="GOA:O31433" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12724" /db_xref="UniProtKB/Swiss-Prot:O31433" /translation="MLLFTAVISVPMLLLAVSVLMSVIYDSMFKPMNHGMPFHRSFAY PAMIVVFLISLLLLAFLFSKSIHSLLHKINLLNQTIRHLASDQRVPDKIEVKRADEIG ELIKSVNLLIERTTYRELELRQQEEIKKELLQKLRHDINTPLTALRLQLFYLEDQCHG QAVFESLYQQIEYISELTNEFNLYSAETLESSYIVNEEVRLNELLETAVKKWDYLYSM SGIELHYKPADQDVIWMSNTLWMERLFDNIFQNTLRHSKAKKMEVTIEHGDVFIRDDG IGFDRNESSEGLGLKIIEDTCRLLAITYELHTNDNGTGFLFSKE*" /label="ybdK CDS" gene 203517..204479 /gene="ybdK" /locus_tag="BSU_02010" /old_locus_tag="BSU02010" /label="ybdK gene" promotor_-35 204491..204493 /Source="Nicolas_upshift_promotors" /id="U136" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.866133866133866" /psig="0.999000999001" /xcortree=2204 /SigmaFactorBS="aacggggttcttgttttcaaaagagtgaccccgctgatgTTT ttctttctcctataaAATTTATATAATAGGGAGAAagaaatggggtgaacatcatatg t" /listShort="ybzI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 204509..204528 /Source="Nicolas_upshift_promotors" /id="U136" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.866133866133866" /psig="0.999000999001" /xcortree=2204 /SigmaFactorBS="aacggggttcttgttttcaaaagagtgaccccgctgatgTTT ttctttctcctataaAATTTATATAATAGGGAGAAagaaatggggtgaacatcatatg t" /listShort="ybzI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 204512 /Source="Nicolas_upshifts" /id="U136" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.866133866133866" /psig="0.999000999001" /xcortree=2204 /SigmaFactorBS="aacggggttcttgttttcaaaagagtgaccccgctgatgTTT ttctttctcctataaAATTTATATAATAGGGAGAAagaaatggggtgaacatcatatg t" /listShort="ybzI" /GFF_Attribute="listLong" /label="upshifts" CDS 204538..204801 /gene="ybzI" /locus_tag="BSU_02019" /old_locus_tag="BSU02019" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097672.1" /db_xref="EnsemblGenomes-Gn:BSU02019" /db_xref="EnsemblGenomes-Tr:CAX52542" /db_xref="UniProtKB/Swiss-Prot:C0H3T1" /translation="MNIICLKKSSKRLSTSQAVLVTDIADTGITAAAGADIIAATAAV RAKEDTTTVMAAVIVTNAGATAAVNPKKVLVPLLGQGFFYVTD*" /label="ybzI CDS" gene 204538..204801 /gene="ybzI" /locus_tag="BSU_02019" /old_locus_tag="BSU02019" /label="ybzI gene" downshifts 204742 /Source="Nicolas_upshifts" /id="D73" /incds=0 /nref=120 /ntot=235 /MaxReadThrough="2.82444" /MaxDrop="4.652" /score="22.3698707" /energy="-12.1" /TU="U135" /idTUdmin="U136" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" CDS complement(204786..205556) /gene="ybdM" /locus_tag="BSU_02030" /old_locus_tag="BSU02030" /EC_number="2.7.11.-" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 21304896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative protein kinase" /protein_id="NP_388085.1" /db_xref="EnsemblGenomes-Gn:BSU02030" /db_xref="EnsemblGenomes-Tr:CAB11997" /db_xref="GOA:O31435" /db_xref="InterPro:IPR000719" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR017441" /db_xref="SubtiList:BG12726" /db_xref="UniProtKB/Swiss-Prot:O31435" /translation="MALKLLKKLLFDRPLKNGVILNHQYKIEECLGMGGYGLVYLCTD ILAQTPYVLKQLRPTKAKKEKEKVRFQQEIKLLKNIHHPQIPGFIDEFIIDGQAYYVM QFIEGENIEELLFFRKQPFTELMALQLISQLLEIIEYLHDRLIFHSDIRTPNIIINDG RLCLIDFGLAKQLTPEEMEEIKVRKQDDFFDLGETLLFLLYSQYKGKKKKNGTWLEEL TLTKEVTLLLKRLLGIEEEYQHTASIREDLNRAIQSVT*" /label="ybdM CDS" gene complement(204786..205556) /gene="ybdM" /locus_tag="BSU_02030" /old_locus_tag="BSU02030" /label="ybdM gene" CDS complement(205642..206499) /gene="ybdN" /locus_tag="BSU_02040" /old_locus_tag="BSU02040" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16794953; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage protein; prophage region 1" /protein_id="NP_388086.1" /db_xref="EnsemblGenomes-Gn:BSU02040" /db_xref="EnsemblGenomes-Tr:CAB11998" /db_xref="SubtiList:BG12727" /db_xref="UniProtKB/Swiss-Prot:O31436" /translation="MVKKWLIQFAVMLSVLSTFTYSASAVGVTAITGNNSFDTAMPIG YWKYKNIDTTILEAGQDEAYFTFTANKGEKVYMRSTYQSAYTGMKIEIYDKNRIPVSQ GTEVINPNTFSSFIYANADAQNTTDTFYVKVSRGTYTGNMYFTLSIEDRIKSGSGTFQ FSGVAENKGNTSLSPSGSDSSVIKVDLTNQSGIPRDAIVTRVQTTATQTPSQGNTRHL IMTSENNEWSRALVNSSTSGSYDISLSDQLSVAKVWSFKYNTLATARSTMSNVKAKID YEYDVTKQF*" /label="ybdN CDS" gene complement(205642..206499) /gene="ybdN" /locus_tag="BSU_02040" /old_locus_tag="BSU02040" /label="ybdN gene" downshifts complement(205664) /Source="Nicolas_upshifts" /id="D74" /incds=0 /nref=95 /ntot=184 /MaxReadThrough="1.56932" /MaxDrop="4.95806" /score="36.4950689" /energy="-11.9" /TU="NA" /idTUdmin="U137" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(205713..205732) /Source="Nicolas_upshift_promotors" /id="U137" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1343 /SigmaFactorBS="ttgtaaacagctcgacttcagggtcttatgatatctctttgt cggatcaactcAGTGTGGCAAaggtatggagtttTAAATATAATACATTAGCGAcagc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(205746..205755) /Source="Nicolas_upshift_promotors" /id="U137" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1343 /SigmaFactorBS="ttgtaaacagctcgacttcagggtcttatgatatctctttgt cggatcaactcAGTGTGGCAAaggtatggagtttTAAATATAATACATTAGCGAcagc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(205748) /Source="Nicolas_upshifts" /id="U137" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1343 /SigmaFactorBS="ttgtaaacagctcgacttcagggtcttatgatatctctttgt cggatcaactcAGTGTGGCAAaggtatggagtttTAAATATAATACATTAGCGAcagc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(206512..206531) /Source="Nicolas_upshift_promotors" /id="U138" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2923 /SigmaFactorBS="ttttatcggcgaatataatgtatatattaacctcaaaaaaca ttTATTTACAcctaaatcgttattATGTATGATGGAAATAAAAGgaggttgtttgcat g" /listShort="ybdN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(206537) /Source="Nicolas_upshifts" /id="U138" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2923 /SigmaFactorBS="ttttatcggcgaatataatgtatatattaacctcaaaaaaca ttTATTTACAcctaaatcgttattATGTATGATGGAAATAAAAGgaggttgtttgcat g" /listShort="ybdN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(206546..206553) /Source="Nicolas_upshift_promotors" /id="U138" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2923 /SigmaFactorBS="ttttatcggcgaatataatgtatatattaacctcaaaaaaca ttTATTTACAcctaaatcgttattATGTATGATGGAAATAAAAGgaggttgtttgcat g" /listShort="ybdN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 206567..206574 /Source="Nicolas_upshift_promotors" /id="U139" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2834 /SigmaFactorBS="ataataacgatttaggtgtaaataaatgttttttgagGTTAA TATatacattatattcGCCGATAAAAAAGAATAAGagagaatactcgggagggaattc a" /listShort="ybdO" /listLong="S80, ybxG" /label="promotor_-35" promotor_-10 206588..206606 /Source="Nicolas_upshift_promotors" /id="U139" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2834 /SigmaFactorBS="ataataacgatttaggtgtaaataaatgttttttgagGTTAA TATatacattatattcGCCGATAAAAAAGAATAAGagagaatactcgggagggaattc a" /listShort="ybdO" /listLong="S80, ybxG" /label="promotor_-10" upshifts 206590 /Source="Nicolas_upshifts" /id="U139" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2834 /SigmaFactorBS="ataataacgatttaggtgtaaataaatgttttttgagGTTAA TATatacattatattcGCCGATAAAAAAGAATAAGagagaatactcgggagggaattc a" /listShort="ybdO" /listLong="S80, ybxG" /label="upshifts" CDS 206631..207815 /gene="ybdO" /locus_tag="BSU_02050" /old_locus_tag="BSU02050" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15033535; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage protein; prophage region 1" /protein_id="NP_388087.1" /db_xref="EnsemblGenomes-Gn:BSU02050" /db_xref="EnsemblGenomes-Tr:CAB11999" /db_xref="InterPro:IPR032617" /db_xref="SubtiList:BG12728" /db_xref="UniProtKB/Swiss-Prot:O31437" /translation="MRLNRQFIRTQLIAQNILSKNAPAKRENATENPAAVLEKAYSRL KSQSSTGGINQFNYSKTSVSGNSGTFSKVYQSANDRTVTDTGEETVIQSQNPYESESD IRIKILDEKYSRMNAINKTKSDPLGYIKDKYQNSKSPYFRSDLSAAERQAAYDNETEW LFKGKAQNYNLQDAVFRNVTFHGEVEAENEKVYQRGQVNQQLQVLLNRNHIHIPEGTE LTFTITPIDYQVRVSGTDDQDLIKQIEQVLQSGDNSKELFLHIMKSQSSDSAQFSEEA YKKYQAAREMYEVTGYHLKDLEVIDGRYVTPEGRDLMDVYKEELEKDPVQKQTASYAI SYYRSELSKIAEAGYNAIPDFILSIDYSNGSLRDVGQSKSYGTGDTGWLEALKRQTGV NY*" /label="ybdO CDS" gene 206631..207815 /gene="ybdO" /locus_tag="BSU_02050" /old_locus_tag="BSU02050" /label="ybdO gene" downshifts 207801 /Source="Nicolas_upshifts" /id="D75" /incds=0 /nref=107 /ntot=207 /MaxReadThrough="2.98334" /MaxDrop="4.9582" /score="-3.87053033" /energy="-8.3" /TU="U139" /idTUdmin="U139" /TUdmin="-181" /isTUend="FALSE" /label="downshifts" promotor_-35 207969..207975 /Source="Nicolas_upshift_promotors" /id="U140" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.430569430569431" /psig="0.999000999001" /xcortree=2998 /SigmaFactorBS="aacaaaggtgtttacctgaaaaaaacAATTGTAttttccaga gaaaTTTATTATGATGAAATAAGTaatttaggagattatataacaattttaagtttga a" /listShort="S80, ybxG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 207989..208008 /Source="Nicolas_upshift_promotors" /id="U140" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.430569430569431" /psig="0.999000999001" /xcortree=2998 /SigmaFactorBS="aacaaaggtgtttacctgaaaaaaacAATTGTAttttccaga gaaaTTTATTATGATGAAATAAGTaatttaggagattatataacaattttaagtttga a" /listShort="S80, ybxG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 208003..208132 /Source="Nicolas_S_feature" /locus_tag="new_226436_226565" /HighExp="Glu, LoTm, M9-stat, G135, GM-0.2, T-0.40H, Fru, UNK1, MG 120, GM-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigD" /TUlongPSig=1 /label="S80" upshifts 208003 /Source="Nicolas_upshifts" /id="U140" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.430569430569431" /psig="0.999000999001" /xcortree=2998 /SigmaFactorBS="aacaaaggtgtttacctgaaaaaaacAATTGTAttttccaga gaaaTTTATTATGATGAAATAAGTaatttaggagattatataacaattttaagtttga a" /listShort="S80, ybxG" /GFF_Attribute="listLong" /label="upshifts" CDS 208133..209521 /gene="ybxG" /locus_tag="BSU_02060" /old_locus_tag="BSU02060" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative amino acid permease" /protein_id="NP_388088.1" /db_xref="EnsemblGenomes-Gn:BSU02060" /db_xref="EnsemblGenomes-Tr:CAB12000" /db_xref="GOA:P54425" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG11505" /db_xref="UniProtKB/Swiss-Prot:P54425" /translation="MANKELKRGLGARHIQMIALGGTIGVGLFMGSASTISWTGPSVL LAYAICGIFIFFIMRAMGEMLYVEPSTGSFATFGHQYIHPMAGYITAWSNWFQWIIVG MSEIIAVGSYTKYWFPDLPAWIPGIVAMVILGAANLISVKSFGEFEFWFAMIKIVTII LMIIAGIGIIFFGFGNGGDAIGLSNLWSHGGFFAGGFSGFFFALSLVIAAYQGVELIG ITAGEAKDPQNTLRNAIQSIIWRILIFYIGAIFVIVTVYPWDELNSLGSPFVSTFSKI GITAAAGIINFVVITAAMSGCNSGIFSAGRMLYTLGVNGQAPKFFKKISRNGVPLYGT IAVLIGLAVGVVLNYIAPPKIFVYVYSASVLPGMIPWFIILISHIGFRKAKGAALDKH PFKMPFAPFTNYLTIAFLLMVLVGMWFNDDTRISLIVGVIFLALVVISYYVFGIGKRT QANLTKSEQAAE*" /label="ybxG CDS" gene 208133..209521 /gene="ybxG" /locus_tag="BSU_02060" /old_locus_tag="BSU02060" /label="ybxG gene" downshifts 209529 /Source="Nicolas_upshifts" /id="D76" /incds=0 /nref=121 /ntot=219 /MaxReadThrough="2.32902" /MaxDrop="5.72049" /score="28.6554212" /energy="-8.5" /TU="NA" /idTUdmin="U140" /TUdmin="-15" /isTUend="TRUE" /label="downshifts" promotor_-35 209567..209573 /Source="Nicolas_upshift_promotors" /id="U141" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=938 /SigmaFactorBS="aaaagagacattcacggatgtctctttttttatttttcgCGT ATGGattttccctatttTAGCAAGCTATAgggtaaagatagcagaaggaaaggtgttc a" /listShort="csgA, ybxH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 209587..209598 /Source="Nicolas_upshift_promotors" /id="U141" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=938 /SigmaFactorBS="aaaagagacattcacggatgtctctttttttatttttcgCGT ATGGattttccctatttTAGCAAGCTATAgggtaaagatagcagaaggaaaggtgttc a" /listShort="csgA, ybxH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 209588 /Source="Nicolas_upshifts" /id="U141" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=938 /SigmaFactorBS="aaaagagacattcacggatgtctctttttttatttttcgCGT ATGGattttccctatttTAGCAAGCTATAgggtaaagatagcagaaggaaaggtgttc a" /listShort="csgA, ybxH" /GFF_Attribute="listLong" /label="upshifts" CDS 209633..209881 /gene="csgA" /locus_tag="BSU_02070" /old_locus_tag="BSU02070" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9016963" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9016963; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sporulation-specific SASP protein" /protein_id="NP_388089.1" /db_xref="EnsemblGenomes-Gn:BSU02070" /db_xref="EnsemblGenomes-Tr:CAB12001" /db_xref="GOA:P54379" /db_xref="InterPro:IPR020255" /db_xref="SubtiList:BG11504" /db_xref="UniProtKB/Swiss-Prot:P54379" /translation="MDVTLGYLRESLSNHLENEVCQRICKKMLAKRYANEEEFVKDLD DNEMSFLNHVLEKEIKYAQNEQDQKRAKELNEVYELLL*" /label="csgA CDS" gene 209633..209881 /gene="csgA" /locus_tag="BSU_02070" /old_locus_tag="BSU02070" /label="csgA gene" CDS 209898..210089 /gene="ybxH" /locus_tag="BSU_02080" /old_locus_tag="BSU02080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388090.1" /db_xref="EnsemblGenomes-Gn:BSU02080" /db_xref="EnsemblGenomes-Tr:CAB12002" /db_xref="InterPro:IPR035314" /db_xref="SubtiList:BG11506" /db_xref="UniProtKB/Swiss-Prot:P54426" /translation="MGAIERSGYTFQPEFSVVRQNGAIHVYHQGEFVEEIEFEFNGEY PDHDLIEELVNHYCFEHEI*" /label="ybxH CDS" gene 209898..210089 /gene="ybxH" /locus_tag="BSU_02080" /old_locus_tag="BSU02080" /label="ybxH gene" downshifts 210071 /Source="Nicolas_upshifts" /id="D77" /incds=0 /nref=17 /ntot=40 /MaxReadThrough="0.194030000000001" /MaxDrop="4.779" /score="29.4617878" /energy="-15.6" /TU="NA" /idTUdmin="U141" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(210116..210919) /gene="ybxI" /locus_tag="BSU_02090" /old_locus_tag="BSU02090" /EC_number="3.5.2.6" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14742199" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14742199; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported beta-lactamase" /protein_id="NP_388091.1" /db_xref="EnsemblGenomes-Gn:BSU02090" /db_xref="EnsemblGenomes-Tr:CAB12003" /db_xref="GOA:P54427" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR002137" /db_xref="InterPro:IPR012338" /db_xref="PDB:5E2F" /db_xref="SubtiList:BG11507" /db_xref="UniProtKB/Swiss-Prot:P54427" /translation="MKKWIYVVLVLSIAGIGGFSVHAASSAHEKHLNVSKMNVDDEFK DTDGTFILHDLQKDQTFVYNRKRANQRQTPQSTFKVVNALIGLQVKAVRDEYDVKRWD GVKREFESWNRDHTLGSAMRESAIWYYQALARDIGEERMKTWLHTLSYGNEDISGGID QFWLQSSLTISPLEQETFLEKLAKEELPFDKPVMKIVKRMMIQEEGDHYTLYGKTGTR LTDMGLGWFVGFIKTEHGSYVFVTNVDDSGTKAKNITVDILKKYGLITS*" /label="ybxI CDS" gene complement(210116..210919) /gene="ybxI" /locus_tag="BSU_02090" /old_locus_tag="BSU02090" /label="ybxI gene" promotor_-10 complement(210941..210959) /Source="Nicolas_upshift_promotors" /id="U142" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=3196 /SigmaFactorBS="accaaatttaagcgctttttgattattttttAAAGGAAGAac aaacgaaaGAGAGAAAAGGTAGTTAATcaaaacgaaggggagaacaaaatgaaaaaat g" /listShort="ybxI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(210949) /Source="Nicolas_upshifts" /id="U142" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=3196 /SigmaFactorBS="accaaatttaagcgctttttgattattttttAAAGGAAGAac aaacgaaaGAGAGAAAAGGTAGTTAATcaaaacgaaggggagaacaaaatgaaaaaat g" /listShort="ybxI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(210970..210978) /Source="Nicolas_upshift_promotors" /id="U142" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=3196 /SigmaFactorBS="accaaatttaagcgctttttgattattttttAAAGGAAGAac aaacgaaaGAGAGAAAAGGTAGTTAATcaaaacgaaggggagaacaaaatgaaaaaat g" /listShort="ybxI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 211033..211039 /Source="Nicolas_upshift_promotors" /id="U143" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=163 /SigmaFactorBS="taaatttggttttgcaaacaaatactgttactgGGTTTATag tcggaagataacGTGAAAATAGAGGGTAAAAaggaaggcagggtaagcggatgaatga g" /listShort="cypC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 211054..211072 /Source="Nicolas_upshift_promotors" /id="U143" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=163 /SigmaFactorBS="taaatttggttttgcaaacaaatactgttactgGGTTTATag tcggaagataacGTGAAAATAGAGGGTAAAAaggaaggcagggtaagcggatgaatga g" /listShort="cypC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 211060 /Source="Nicolas_upshifts" /id="U143" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=163 /SigmaFactorBS="taaatttggttttgcaaacaaatactgttactgGGTTTATag tcggaagataacGTGAAAATAGAGGGTAAAAaggaaggcagggtaagcggatgaatga g" /listShort="cypC" /GFF_Attribute="listLong" /label="upshifts" CDS 211092..212345 /gene="cypC" /locus_tag="BSU_02100" /old_locus_tag="BSU02100" /EC_number="1.11.2.4" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10529095, 12519760, 21673922" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10529095, 12519760, 21673922; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fatty acid beta-hydroxylating cytochrome P450" /protein_id="NP_388092.1" /db_xref="EnsemblGenomes-Gn:BSU02100" /db_xref="EnsemblGenomes-Tr:CAB12004" /db_xref="GOA:O31440" /db_xref="InterPro:IPR001128" /db_xref="InterPro:IPR002401" /db_xref="InterPro:IPR036396" /db_xref="PDB:1IZO" /db_xref="PDB:2ZQJ" /db_xref="PDB:2ZQX" /db_xref="SubtiList:BG12729" /db_xref="UniProtKB/Swiss-Prot:O31440" /translation="MNEQIPHDKSLDNSLTLLKEGYLFIKNRTERYNSDLFQARLLGK NFICMTGAEAAKVFYDTDRFQRQNALPKRVQKSLFGVNAIQGMDGSAHIHRKMLFLSL MTPPHQKRLAELMTEEWKAAVTRWEKADEVVLFEEAKEILCRVACYWAGVPLKETEVK ERADDFIDMVDAFGAVGPRHWKGRRARPRAEEWIEVMIEDARAGLLKTTSGTALHEMA FHTQEDGSQLDSRMAAIELINVLRPIVAISYFLVFSALALHEHPKYKEWLRSGNSRER EMFVQEVRRYYPFGPFLGALVKKDFVWNNCEFKKGTSVLLDLYGTNHDPRLWDHPDEF RPERFAEREENLFDMIPQGGGHAEKGHRCPGEGITIEVMKASLDFLVHQIEYDVPEQS LHYSLARMPSLPESGFVMSGIRRKS*" /label="cypC CDS" gene 211092..212345 /gene="cypC" /locus_tag="BSU_02100" /old_locus_tag="BSU02100" /label="cypC gene" misc_feature 211404..211411 /Source="Nicolas_upshift_promotors" /id="U144" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.454545454545455" /psig="0.013986013986014" /xcortree=116 /SigmaFactorBS="atggcagcgcgcatatccatcggaagatgctttttctgtcat tgatgacaCCGCCGCAtcaaaaacgtttggctgagttgatgacagaggagtggaaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 211414 /Source="Nicolas_upshifts" /id="U144" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.454545454545455" /psig="0.013986013986014" /xcortree=116 /SigmaFactorBS="atggcagcgcgcatatccatcggaagatgctttttctgtcat tgatgacaCCGCCGCAtcaaaaacgtttggctgagttgatgacagaggagtggaaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 212338 /Source="Nicolas_upshifts" /id="D78" /incds=0 /nref=5 /ntot=36 /MaxReadThrough="2.65245" /MaxDrop="6.12325" /score="-7.42298703" /energy="-14.7" /TU="NA" /idTUdmin="U143" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(212386..212646) /gene="ybyB" /locus_tag="BSU_02110" /old_locus_tag="BSU02110" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388093.1" /db_xref="EnsemblGenomes-Gn:BSU02110" /db_xref="EnsemblGenomes-Tr:CAB12005" /db_xref="SubtiList:BG12754" /db_xref="UniProtKB/Swiss-Prot:O31441" /translation="MKQKLLLSGLAVSTVGITSYLLKDPSNRQKAREFIHSMKMKITK QPDMETFPVDKAGHPDPQDIEDNKMVSEGSMYPVQYYDEKKK*" /label="ybyB CDS" gene complement(212386..212646) /gene="ybyB" /locus_tag="BSU_02110" /old_locus_tag="BSU02110" /label="ybyB gene" downshifts complement(212405) /Source="Nicolas_upshifts" /id="D79" /incds=0 /nref=155 /ntot=247 /MaxReadThrough="3.63752" /MaxDrop="7.83539" /score="8.86703843" /energy="-12.4" /TU="U145" /idTUdmin="U145" /TUdmin="-387" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(212676..212694) /Source="Nicolas_upshift_promotors" /id="U145" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=227 /SigmaFactorBS="tactgttaattccaatgataaaaacacaacaGGTTTAGcaat ttccaaaacGGGAATGATACAGGAAACActattcttaaaatagaaaggagtatcacca t" /listShort="ybyB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(212685) /Source="Nicolas_upshifts" /id="U145" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=227 /SigmaFactorBS="tactgttaattccaatgataaaaacacaacaGGTTTAGcaat ttccaaaacGGGAATGATACAGGAAACActattcttaaaatagaaaggagtatcacca t" /listShort="ybyB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(212708..212714) /Source="Nicolas_upshift_promotors" /id="U145" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=227 /SigmaFactorBS="tactgttaattccaatgataaaaacacaacaGGTTTAGcaat ttccaaaacGGGAATGATACAGGAAACActattcttaaaatagaaaggagtatcacca t" /listShort="ybyB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 212838..212845 /Source="Nicolas_upshift_promotors" /id="U146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2207 /SigmaFactorBS="atatacattgacttattatagatttcagtcaaaattcgataa aTATTGACAaagtaaagtaatcagAATAATAATATAATTAGCAAgagaatgtcatcat a" /listShort="ybeC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 212855 /Source="Nicolas_upshifts" /id="U146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2207 /SigmaFactorBS="atatacattgacttattatagatttcagtcaaaattcgataa aTATTGACAaagtaaagtaatcagAATAATAATATAATTAGCAAgagaatgtcatcat a" /listShort="ybeC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 212861..212880 /Source="Nicolas_upshift_promotors" /id="U146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2207 /SigmaFactorBS="atatacattgacttattatagatttcagtcaaaattcgataa aTATTGACAaagtaaagtaatcagAATAATAATATAATTAGCAAgagaatgtcatcat a" /listShort="ybeC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 212915..214534 /gene="ybeC" /locus_tag="BSU_02120" /old_locus_tag="BSU02120" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative H+/amino acid transporter" /protein_id="NP_388094.2" /db_xref="EnsemblGenomes-Gn:BSU02120" /db_xref="EnsemblGenomes-Tr:CAB12006" /db_xref="GOA:Q45577" /db_xref="InterPro:IPR002293" /db_xref="SubtiList:BG12730" /db_xref="UniProtKB/Swiss-Prot:Q45577" /translation="MNQLHRRMGTFSLMMVGLGSMIGSGWLFGAWRAAQIAGPAAIIS WVIGMVVILFIALSYSELGSMFPEAGGMVKYTQYSHGSFIGFIAGWANWIAIVSVIPV EAVASVQYMSSWPWEWAKWTSGLVKNGTLTGEGLAFASVLLLIYFLLNYWTVNLFSKA NSLITIFKIIIPGLTIGALLFVGFHGENFTGGQSIAPNGWASVLTAVATSGIVFAFNG FQSPINMAGEAKNPGKSIPIAVVGSLFVATVIYVLLQIAFIGAVNPSDIAHGWSHLNF NSPFADLAIALNINWLVIVLYADAFVSPSGTGITYTATTSRMIYGMEKNKYMPSIFGK LHPIYGVPRQAMFFNLIVSFIFLFLFRGWGVLAEIISVATLISYITGPITVMTLRRTG KDLYRPLRLKGLNVIAPLGFIFASLVLYWARWPLTGQVLFIILIGLPIYFYYQAKAKW KGFGRNFKAGVWMVFYLLAMMVISYLGSDKFGGLNVIHYGWDMVLIAMVSLVFYVWAL KSGYQTEYLKDAKEINSQLLNGQSEAAAGKE*" /label="ybeC CDS" gene 212915..214534 /gene="ybeC" /locus_tag="BSU_02120" /old_locus_tag="BSU02120" /label="ybeC gene" downshifts 214517 /Source="Nicolas_upshifts" /id="D80" /incds=0 /nref=183 /ntot=273 /MaxReadThrough="0.8051" /MaxDrop="6.79949" /score="24.7668372" /energy="-12.2" /TU="NA" /idTUdmin="U146" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" CDS complement(214581..215462) /gene="glpQA" /locus_tag="BSU_02130" /old_locus_tag="BSU02130" /EC_number="3.1.4.46" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10913081, 21966272" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10913081, 21966272; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="secreted glycerophosphoryl diester phosphodiesterase" /protein_id="NP_388095.1" /db_xref="EnsemblGenomes-Gn:BSU02130" /db_xref="EnsemblGenomes-Tr:CAB12007" /db_xref="GOA:P37965" /db_xref="InterPro:IPR004129" /db_xref="InterPro:IPR017946" /db_xref="InterPro:IPR030395" /db_xref="PDB:5T91" /db_xref="PDB:5T9B" /db_xref="PDB:5T9C" /db_xref="SubtiList:BG10646" /db_xref="UniProtKB/Swiss-Prot:P37965" /translation="MRKNRILALFVLSLGLLSFMVTPVSAASKGNLLSPDRILTVAHR GASGYVPEHTILSYETAQKMKADFIELDLQMTKDGKLIVMHDEKLDRTTNGMGWVKDH TLADIKKLDAGSWFNEAYPEKAKPQYVGLKVPTLEEVLDRFGKHANYYIETKSPDTYP GMEEKLIASLQKHKLLGKHSKPGQVIIQSFSKESLVKVHQLQPNLPTVQLLEAKQMAS MTDAALEEIKTYAVGAGPDYKALNQENVRMIRSHGLLLHPYTVNNEADMHRLLDWGVT GVFTNYPDLFHKVKKGY*" /label="glpQA CDS" gene complement(214581..215462) /gene="glpQA" /locus_tag="BSU_02130" /old_locus_tag="BSU02130" /label="glpQA gene" downshifts complement(214592) /Source="Nicolas_upshifts" /id="D81" /incds=0 /nref=61 /ntot=107 /MaxReadThrough="2.31368" /MaxDrop="7.76277" /score="9.56390732" /energy="-11.4" /TU="NA" /idTUdmin="U147" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(215505) /Source="Nicolas_upshifts" /id="U147" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.738261738261738" /psig="0.0999000999001" /xcortree=4 /SigmaFactorBS="tttaagaaagacacataaaaGATTAATagttttccAACACGC CGTTTACATCcgttttttattatgaaagacaggtagtgcttatctataaggaggagaa a" /listShort="glpQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(215514..215530) /Source="Nicolas_upshift_promotors" /id="U147" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.738261738261738" /psig="0.0999000999001" /xcortree=4 /SigmaFactorBS="tttaagaaagacacataaaaGATTAATagttttccAACACGC CGTTTACATCcgttttttattatgaaagacaggtagtgcttatctataaggaggagaa a" /listShort="glpQ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(215539..215545) /Source="Nicolas_upshift_promotors" /id="U147" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.738261738261738" /psig="0.0999000999001" /xcortree=4 /SigmaFactorBS="tttaagaaagacacataaaaGATTAATagttttccAACACGC CGTTTACATCcgttttttattatgaaagacaggtagtgcttatctataaggaggagaa a" /listShort="glpQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(215561..216895) /gene="glpT" /locus_tag="BSU_02140" /old_locus_tag="BSU02140" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8012593, 11929549, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8012593, 11929549, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sn-glycerol-3-phosphate permease" /protein_id="NP_388096.1" /db_xref="EnsemblGenomes-Gn:BSU02140" /db_xref="EnsemblGenomes-Tr:CAB12008" /db_xref="GOA:P37948" /db_xref="InterPro:IPR000849" /db_xref="InterPro:IPR005267" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR021159" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10645" /db_xref="UniProtKB/Swiss-Prot:P37948" /translation="MLNIFKPAPHIERLDDSKMDAAYKRLRLQVFIGIFIGYAGYYLL RKNFAFAIPYLQEQGFSKTELGLVLAAVSIAYGFSKFIMGMVSDRCNPRYFLATGLFL SAIVNILFVSMPWVTSSVTIMFIFMFINGWFQGMGWPPCGRTMAHWFSISERGTKMSI WNVAHNIGGGILAPLVTLGIAMFVTWKSVFFFPAIIAIIISFLIVLLVRDTPQSCGLP PIEEYRNDYPKHAFKNQEKELTTKEILFQYVLNNKFLWYIAFANVFVYFVRYGVVDWA PTYLTEAKGFSPEDSRWSYFLYEYAGIPGTILCGWISDRFFKSRRAPAGVLFMAGVFI AVLVYWLNPAGNPLVDNIALISIGFLIYGPVMLIGLQAIDLAPKKAAGTAAGLTGFFG YIGGSAFANAIMGFVVDRFNWNGGFIMLISSCILAIVFLALTWNTGKRAEHV*" /label="glpT CDS" gene complement(215561..216895) /gene="glpT" /locus_tag="BSU_02140" /old_locus_tag="BSU02140" /label="glpT gene" promotor_-35 216543..216552 /Source="Nicolas_upshift_promotors" /id="U148" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1339 /SigmaFactorBS="cgttgataaacataaaaataaacatgatggtgacgctcGAAG TCACCCaaggcattgaaaCGAATAGAATATTAACGATTgctgataaaaataggcctgt c" /listShort="S81, ybeF, ybfA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 216565..217191 /Source="Nicolas_S_feature" /locus_tag="new_234998_235624" /HighExp="S6, S8, S7, S5, BT, B36, G/S, C30, Pyr, B60" /AntisenseName="glpT" /AntisenseCor="-5.0958691169636701E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S81" promotor_-10 216565..216584 /Source="Nicolas_upshift_promotors" /id="U148" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1339 /SigmaFactorBS="cgttgataaacataaaaataaacatgatggtgacgctcGAAG TCACCCaaggcattgaaaCGAATAGAATATTAACGATTgctgataaaaataggcctgt c" /listShort="S81, ybeF, ybfA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 216565 /Source="Nicolas_upshifts" /id="U148" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1339 /SigmaFactorBS="cgttgataaacataaaaataaacatgatggtgacgctcGAAG TCACCCaaggcattgaaaCGAATAGAATATTAACGATTgctgataaaaataggcctgt c" /listShort="S81, ybeF, ybfA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(216896..216968) /Source="Nicolas_S_feature" /locus_tag="new_235329_235401_c" /HighExp="G150, Oxctl, Paraq, S0, Diami, H2O2, Lbexp, dia5, dia0, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.042, 0.935" /TUlongSig="NA" /TUlongPSig="NA" /label="S82" promotor_no_box complement(216928..217028) /Source="Nicolas_upshift_promotors" /id="U149" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.370629370629371" /psig="0.041958041958042" /xcortree=1566 /SigmaFactorBS="tagcttggatggagatgaggagagccaggaatccaacccctt ttgacaaggggtgttttctggctctttttgtttttcgggaaaggaggcacgccacaca t" /listShort="S82, glpT, glpQ" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(216968) /Source="Nicolas_upshifts" /id="U149" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.370629370629371" /psig="0.041958041958042" /xcortree=1566 /SigmaFactorBS="tagcttggatggagatgaggagagccaggaatccaacccctt ttgacaaggggtgttttctggctctttttgtttttcgggaaaggaggcacgccacaca t" /listShort="S82, glpT, glpQ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(216970..217056) /Source="Nicolas_S_feature" /locus_tag="new_235403_235489_c" /HighExp="G150, Oxctl, S0, Diami, Lbexp, dia5, Paraq, dia0, T0.30H, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.935" /TUlongSig="NA" /TUlongPSig="NA" /label="S83" promotor_-10 complement(217046..217065) /Source="Nicolas_upshift_promotors" /id="U150" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.396603396603397" /psig="0.935064935064935" /xcortree=1567 /SigmaFactorBS="tattcacttccctaaggcccaatttgaaaattaccCGTTTAC AttcgctccggacTATGATAATTTAAGAAAGCGctatcatgataagttaatagcttgg a" /listShort="S83, S82, glpT, glpQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(217060) /Source="Nicolas_upshifts" /id="U150" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.396603396603397" /psig="0.935064935064935" /xcortree=1567 /SigmaFactorBS="tattcacttccctaaggcccaatttgaaaattaccCGTTTAC AttcgctccggacTATGATAATTTAAGAAAGCGctatcatgataagttaatagcttgg a" /listShort="S83, S82, glpT, glpQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(217078..217085) /Source="Nicolas_upshift_promotors" /id="U150" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.396603396603397" /psig="0.935064935064935" /xcortree=1567 /SigmaFactorBS="tattcacttccctaaggcccaatttgaaaattaccCGTTTAC AttcgctccggacTATGATAATTTAAGAAAGCGctatcatgataagttaatagcttgg a" /listShort="S83, S82, glpT, glpQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS 217192..217440 /gene="ybeF" /locus_tag="BSU_02150" /old_locus_tag="BSU02150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388097.1" /db_xref="EnsemblGenomes-Gn:BSU02150" /db_xref="EnsemblGenomes-Tr:CAB12009" /db_xref="GOA:O31442" /db_xref="InterPro:IPR020258" /db_xref="SubtiList:BG12731" /db_xref="UniProtKB/Swiss-Prot:O31442" /translation="MDELDIAFFILPLGIMLLSIVGTCICKNPYLMPMLSLVISLVLT FTIFNQSFLGWAVVYSLVSLALSYITLIVVRKRKESGN*" /label="ybeF CDS" gene 217192..217440 /gene="ybeF" /locus_tag="BSU_02150" /old_locus_tag="BSU02150" /label="ybeF gene" promotor_-35 217464..217471 /Source="Nicolas_upshift_promotors" /id="U151" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.801198801198801" /psig="0.984015984015984" /xcortree=3080 /SigmaFactorBS="gtaaggaaaaggaaggaatcaggaaattaaaaagacctcact ttctaacatatCGTTGACTaaagcaactatatgtGATTATAATTGCTTTAGTCAacga t" /listShort="ybfA, ybfB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 217471 /Source="Nicolas_upshifts" /id="U151" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.801198801198801" /psig="0.984015984015984" /xcortree=3080 /SigmaFactorBS="gtaaggaaaaggaaggaatcaggaaattaaaaagacctcact ttctaacatatCGTTGACTaaagcaactatatgtGATTATAATTGCTTTAGTCAacga t" /listShort="ybfA, ybfB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 217487..217506 /Source="Nicolas_upshift_promotors" /id="U151" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.801198801198801" /psig="0.984015984015984" /xcortree=3080 /SigmaFactorBS="gtaaggaaaaggaaggaatcaggaaattaaaaagacctcact ttctaacatatCGTTGACTaaagcaactatatgtGATTATAATTGCTTTAGTCAacga t" /listShort="ybfA, ybfB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 217532..218449 /gene="ybfA" /locus_tag="BSU_02160" /old_locus_tag="BSU02160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator with acetyltransferase domain" /protein_id="NP_388098.1" /db_xref="EnsemblGenomes-Gn:BSU02160" /db_xref="EnsemblGenomes-Tr:CAB12010" /db_xref="GOA:O31443" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12732" /db_xref="UniProtKB/Swiss-Prot:O31443" /translation="MKTRESSVGLKFRKFNRFYTNVLGFLNEHIYDSPFSLTETRILF EIYNTPNCTAKALQDKLGLDRGYVSRIVKQFEKEDLIYKQRSKDDARHHYIFVTETGK TIYKKLEEKANEQVELMLKVINQKEQHKLAEAMAEIEAILSQSLSARASEISIRDYFL SEDLQLLIEKQRQFYAEAHGWDDTFLAYLQETFDADIEKIWIAESGGKFAGSVGLVKH DEKTVQLRWFLVDADFRGRGLGTQLLEHLVAYCQDMKFDRIFLWTVSTMAEARPLYKK FGFRISEVKQEAPLWGQQLTEERWDLELS*" /label="ybfA CDS" gene 217532..218449 /gene="ybfA" /locus_tag="BSU_02160" /old_locus_tag="BSU02160" /label="ybfA gene" CDS 218446..219696 /gene="ybfB" /locus_tag="BSU_02170" /old_locus_tag="BSU02170" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative carboxylate transporter" /protein_id="NP_388099.1" /db_xref="EnsemblGenomes-Gn:BSU02170" /db_xref="EnsemblGenomes-Tr:CAB12011" /db_xref="GOA:O31444" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12733" /db_xref="UniProtKB/Swiss-Prot:O31444" /translation="MKRLHYAWIIVSVTFLILLAVQGVRLSFGAFVEPWERQFSIDRS TISLISTVSFIVYGISQPVIGRLVDKWGARAVLAWSALLTGVSIFLTYLVTSPWQLFL LYGLGVSLGVGGASNVAASVLVVNWFSKKRGLAFGIMEAGFGAGQMLLVPGSLMLIHW FSWKLTVVVLGLLLIVIVFPAALLMLRNNPSEKNTEPIGGLAASEKETAPKTTALSVA GMFRMRQFWFLIFPFLICGFTTVGLMDTHLIPFSHDHGFSTTVTSAAVSLLAGFNIAG ILLSGIVADRWSSRKILCILYAVRALSIVILIYSHEPYLLLAFAILFGLVDFATVAPT QMLATQYFQNYSIGLMIGWLSLAHQIGSALGAYVPGVIYTVTGEYTLAFYLSIGMLVL ASVMNVMLREPAAVTRDSAAVVDK*" /label="ybfB CDS" gene 218446..219696 /gene="ybfB" /locus_tag="BSU_02170" /old_locus_tag="BSU02170" /label="ybfB gene" downshifts 219686 /Source="Nicolas_upshifts" /id="D82" /incds=0 /nref=57 /ntot=187 /MaxReadThrough="1.17226" /MaxDrop="5.55429" /score="12.1347284" /energy="-9.5" /TU="NA" /idTUdmin="U151" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(219731..220015) /gene="ybfEc" /locus_tag="BSU_02180" /old_locus_tag="BSU02180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (C-terminal end)" /db_xref="EnsemblGenomes-Gn:BSU02180" /db_xref="EnsemblGenomes-Tr:CAB12012" /db_xref="GOA:O31445" /db_xref="PSEUDO:CAB12012.2" /db_xref="SubtiList:BG12734" /db_xref="UniProtKB/Swiss-Prot:O31445" /translation="MNHCLHSNTLAKIVCTVTLITLYFYFFSTRFNELIELAVQMFFA LIGLFWVFIVSPFSRKVQISERFKQKSENARIVGMIDFVLEQKYKKSISE*" /label="ybfEc CDS" gene complement(219731..220015) /gene="ybfEc" /locus_tag="BSU_02180" /old_locus_tag="BSU02180" /pseudo /label="ybfEc gene" downshifts complement(219784) /Source="Nicolas_upshifts" /id="D83" /incds=0 /nref=4 /ntot=189 /MaxReadThrough="2.49989" /MaxDrop="3.7302" /score="13.7144473" /energy="-12.6" /TU="U153" /idTUdmin="U153" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(219921..220043) /gene="ybfEn" /locus_tag="BSU_02181" /old_locus_tag="BSU02181" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved protein of unknown function YbfE (N-terminal fragment)" /db_xref="PSEUDO:SOX90538.1" /translation="MLNQLKVFFSEPLLTFKHTCQNRMYCDINNVILLFFQHSF*" /label="ybfEn CDS" gene complement(219921..220043) /gene="ybfEn" /locus_tag="BSU_02181" /old_locus_tag="BSU02181" /pseudo /label="ybfEn gene" S_feature complement(220016..220136) /Source="Nicolas_S_feature" /locus_tag="new_238449_238569_c" /HighExp="Lbexp, dia0, LBGexp, G150, Mt0, H2O2, dia5, M0t45, G135, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, Sig-" /TUshortPSig="0.899, 0" /TUlongSig="NA" /TUlongPSig="NA" /label="S84" promotor_-10 complement(220121..220139) /Source="Nicolas_upshift_promotors" /id="U152" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.899100899100899" /psig="0.899100899100899" /xcortree=1463 /SigmaFactorBS="tactaagaaatactcaatttttatactttaagagaTGTATAt attgaatgtagaccaCCATACATATAAAGAAACAgaaacagcaactttattttagaac a" /listShort="S84, ybfE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(220136) /Source="Nicolas_upshifts" /id="U152" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.899100899100899" /psig="0.899100899100899" /xcortree=1463 /SigmaFactorBS="tactaagaaatactcaatttttatactttaagagaTGTATAt attgaatgtagaccaCCATACATATAAAGAAACAgaaacagcaactttattttagaac a" /listShort="S84, ybfE" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(220138..220210) /Source="Nicolas_S_feature" /locus_tag="new_238571_238643_c" /HighExp="Lbexp, dia0, LBGexp, HPh, G150, H2O2, dia5, Mt0, M0t45, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig=0 /TUlongSig="NA" /TUlongPSig="NA" /label="S85" promotor_-35 complement(220156..220161) /Source="Nicolas_upshift_promotors" /id="U152" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.899100899100899" /psig="0.899100899100899" /xcortree=1463 /SigmaFactorBS="tactaagaaatactcaatttttatactttaagagaTGTATAt attgaatgtagaccaCCATACATATAAAGAAACAgaaacagcaactttattttagaac a" /listShort="S84, ybfE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(220211..221122) /gene="ybfF" /locus_tag="BSU_02190" /old_locus_tag="BSU02190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388101.1" /db_xref="EnsemblGenomes-Gn:BSU02190" /db_xref="EnsemblGenomes-Tr:CAB12013" /db_xref="GOA:O31446" /db_xref="SubtiList:BG12735" /db_xref="UniProtKB/Swiss-Prot:O31446" /translation="MKNDQIVFEKTKNIAHDINQMQNQQEIIDYLFRQDSLTLNQLKH YYSEPSLPLQFLVKVAVLCMFISMTLASFLFIQAKEVFTNTILSDISPAVFSIFTVIC IFMTYTKIIKKGNKNKGKASLNQRSEFYEKNKLINTILYKKYKMDQQNIQANKHTASD NEDSMNFSAVLNHVLTISKNDKELLGYLDTRDNAMLSQLKAYFSTRPFSLPHYMSLMF CGSIIVVYATSLFSGQINYIDIPHIFIFLLLIIFLKILIDLIKLLNISRKGQLHTVLH FAQRAEYLRMRGVIDFILTERYNKKIM*" /label="ybfF CDS" gene complement(220211..221122) /gene="ybfF" /locus_tag="BSU_02190" /old_locus_tag="BSU02190" /label="ybfF gene" S_feature complement(221123..221210) /Source="Nicolas_S_feature" /locus_tag="new_239556_239643_c" /HighExp="LBGexp, Lbexp, G150, dia5, dia0, G135, Oxctl, H2O2, Mt0, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig=0 /TUlongSig="NA" /TUlongPSig="NA" /label="S86" CDS complement(221211..223409) /gene="ybfG" /locus_tag="BSU_02200" /old_locus_tag="BSU02200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative pepdidoglycan binding protein" /protein_id="NP_388102.1" /db_xref="EnsemblGenomes-Gn:BSU02200" /db_xref="EnsemblGenomes-Tr:CAB12014" /db_xref="GOA:O31447" /db_xref="InterPro:IPR002477" /db_xref="InterPro:IPR015020" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR036365" /db_xref="InterPro:IPR036366" /db_xref="SubtiList:BG12736" /db_xref="UniProtKB/Swiss-Prot:O31447" /translation="MVDEMVLITQQWLNDTYSGKHGYNPVEESGKTGWDTIYGLTRAL QIELGISEPADNFGPTTQRLFKPLKRQAPDSKPSNMNFILQGALWCKGFNPGGFTGVF YEKTENAVKEFQKAAGLTTQDGIVTTLIMKALLDMSAFKLVSGGDSRIRQIQQNLNRD YNDYIGLMPCDGLYGRDTNKALIYALQKEEGMSTSVANGFFGNGTTSLCPTLTPGDSR TGFVLIVQYALYCNGKSFDPGEFDGKYGVGVVSAVKAFQEFMCLPQTGYADMPTIKAL LSSSGDTTRTASACDTATIITAEKAQTLRNNGYKTVGRYLTGNVRTSSGLTSKALTSK ELAVILDAGLKVFPIYQDGGYESSYFVKDQGTRDAYSAASAARRLGFPSGTTIYFAVD FDAYDYEVTDKIIPYFQEIKSAFTKMQTFSTAPKYEIGVYGPRNICIRTSEAGLTKYS FVANMSTGFSGNLGYPMPNNWAFDQFYEGTIGSGSGSIGIDKDGYSGRDSGASNVNPP SDPVYDARLRTLTDILSTIPALENLTSLANAMFEFDTTETIFTSPELDIILSTSLLAT IPSEGSPNTITITNGKPGAYITGLLGDTQTSLTASQIDSYQNLLNSLSLSVRNGYLEV YVNPTAESLNIQIKIYTPDIPVGDNVTTGLTTTITFKIKTYKGVPVTSPESELALDWP SYDQYLFPVVGVAALLLIGNMGSDLTNNKGVKVATALSAMLLAIFAYYTS*" /label="ybfG CDS" gene complement(221211..223409) /gene="ybfG" /locus_tag="BSU_02200" /old_locus_tag="BSU02200" /label="ybfG gene" misc_feature complement(223444..223462) /Source="Nicolas_upshift_promotors" /id="U153" /multdbtbs="-" /comp="M12" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=1523 /SigmaFactorBS="ctgttggagaacggatgtaaaatggatgcttaacggcatcca tttttttattttGTCCTACGTTTGCCACCTAtaaatgaacgcaatctaacaaaggagg a" /listShort="ybfG, S86, ybfF, S85, S84, ybfE" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(223456) /Source="Nicolas_upshifts" /id="U153" /multdbtbs="-" /comp="M12" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=1523 /SigmaFactorBS="ctgttggagaacggatgtaaaatggatgcttaacggcatcca tttttttattttGTCCTACGTTTGCCACCTAtaaatgaacgcaatctaacaaaggagg a" /listShort="ybfG, S86, ybfF, S85, S84, ybfE" /GFF_Attribute="listLong" /label="upshifts" CDS complement(223484..224404) /gene="ybfH" /locus_tag="BSU_02210" /old_locus_tag="BSU02210" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388103.1" /db_xref="EnsemblGenomes-Gn:BSU02210" /db_xref="EnsemblGenomes-Tr:CAB12015" /db_xref="GOA:O31448" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG12737" /db_xref="UniProtKB/Swiss-Prot:O31448" /translation="MNIQRETSGHIAAIVTILIWGTTFISTKVLLADFSPMEILFYRF LMGFIALILVRPNMIPFRNWRQELLFAGAGLFGVTLYFLLENIALTYTYASNVGMIVS IIPMITAVLAHFLLEGEKLRLTFLIGFISALIGLLLITFNGNVVLRLNPLGDIMAAGA ALVFGGYSIFMKKLSAYEYHIIELTQRVFLYGLLFMVPALFLFDFHFDLSRFSSASNI LNMLFLGIGASALCFATWNYSVGVLGAVKSSAYIYMVPVITIAASVLILHENMTWIAL LGGALTLLGLYISELKPKAKLLENGCKMDA*" /label="ybfH CDS" gene complement(223484..224404) /gene="ybfH" /locus_tag="BSU_02210" /old_locus_tag="BSU02210" /label="ybfH gene" CDS complement(224401..225228) /gene="ybfI" /locus_tag="BSU_02220" /old_locus_tag="BSU02220" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (AraC/XylS family, cupin family)" /protein_id="NP_388104.1" /db_xref="EnsemblGenomes-Gn:BSU02220" /db_xref="EnsemblGenomes-Tr:CAB12016" /db_xref="GOA:O31449" /db_xref="InterPro:IPR003313" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR018060" /db_xref="SubtiList:BG12738" /db_xref="UniProtKB/Swiss-Prot:O31449" /translation="MQNETRTLQLDPHLHIEAYRFKGIMQKFPNHFHDYYVIGFIEKG QRYLACQDQEYIINPGDLLLFNPRDTHSCEQIDGRTLDYRCINVMPDIMEKAVKEITG SGHLPYFSQHVLFRHELTASLQELHILISEEKQALRKEELFLHLLEELIRHYSDVTFL SSVPEPSDEVKMVCEFLEEHYAENVTLNDLSELTGWSKYHLLRSFTKQKGITPNSYME TIRINQAKKLLEQGVRPIDAAFQTGFSDQSHMTKFFKRQVGLTPKQYMKIFEKELHR* " /label="ybfI CDS" gene complement(224401..225228) /gene="ybfI" /locus_tag="BSU_02220" /old_locus_tag="BSU02220" /label="ybfI gene" misc_feature complement(225255..225274) /Source="Nicolas_upshift_promotors" /id="U154" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=583 /SigmaFactorBS="ctttctctattcctaaacagcaacatcatacaagaaatcccc caaaatCATGCTACACTTAATCCAAGaccaccacaccgacaggaggcatcccatgcaa a" /listShort="ybfI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(225262) /Source="Nicolas_upshifts" /id="U154" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=583 /SigmaFactorBS="ctttctctattcctaaacagcaacatcatacaagaaatcccc caaaatCATGCTACACTTAATCCAAGaccaccacaccgacaggaggcatcccatgcaa a" /listShort="ybfI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 225402..225405 /Source="Nicolas_upshift_promotors" /id="U155" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.999000999001" /xcortree=2313 /SigmaFactorBS="tttaaccctcaataataattttatcttttttaataaaAATTt atttttcaaatatTTCAGTTATAATGGTTTGGAacagataggaggggcaaagatgtat c" /listShort="purT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 225420..225439 /Source="Nicolas_upshift_promotors" /id="U155" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.999000999001" /xcortree=2313 /SigmaFactorBS="tttaaccctcaataataattttatcttttttaataaaAATTt atttttcaaatatTTCAGTTATAATGGTTTGGAacagataggaggggcaaagatgtat c" /listShort="purT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 225425 /Source="Nicolas_upshifts" /id="U155" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.999000999001" /xcortree=2313 /SigmaFactorBS="tttaaccctcaataataattttatcttttttaataaaAATTt atttttcaaatatTTCAGTTATAATGGTTTGGAacagataggaggggcaaagatgtat c" /listShort="purT" /GFF_Attribute="listLong" /label="upshifts" CDS 225459..226613 /gene="purT" /locus_tag="BSU_02230" /old_locus_tag="BSU02230" /EC_number="2.1.2.-" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7496533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7496533; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylglycinamide formyltransferase 2" /protein_id="NP_388105.1" /db_xref="EnsemblGenomes-Gn:BSU02230" /db_xref="EnsemblGenomes-Tr:CAB12017" /db_xref="GOA:P39771" /db_xref="InterPro:IPR003135" /db_xref="InterPro:IPR005862" /db_xref="InterPro:IPR011054" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="SubtiList:BG10924" /db_xref="UniProtKB/Swiss-Prot:P39771" /translation="MYQSKKVLLLGSGELGKEVVIEAQRLGVQTVAVDSYEHAPAMQV AHNSYVVDMLDPEQIRTIIEKENPDLIVPEVEAIATDELLKLEEEGFHVIPNARAAKL TMDREGIRRLAAETLGLATAGYEFANTYDEFIQAAAQIGFPCVVKPLMSSSGKGQSVC RSEADLESCWETAMEGGRVKNGRVIVEEFIPFESEITLLTVRAVNGTAFCEPIGHVQK DGDYIESWQPHDMTEQQIEEAKHIAKTITDELGGYGLFGVELFLAKDRVYFSEVSPRP HDTGLVTLVTQNLSEFALHVRAILGFPITEITQLSPGASRPLKAPEELADYTVEGLEN ALAVPKTQVRVFGKPITKAGRRMAVALSAADSVETARENAKKALDQLILK*" /label="purT CDS" gene 225459..226613 /gene="purT" /locus_tag="BSU_02230" /old_locus_tag="BSU02230" /label="purT gene" downshifts 226594 /Source="Nicolas_upshifts" /id="D84" /incds=0 /nref=100 /ntot=189 /MaxReadThrough="2.6996" /MaxDrop="5.22319" /score="39.2561117" /energy="-15.1" /TU="NA" /idTUdmin="U155" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 226674..226679 /Source="Nicolas_upshift_promotors" /id="U156" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1104 /SigmaFactorBS="ttgtcatgggacaaggcctgtttttttctttctccgtaaaag ttttATCATAagaatcagaaacctGATTATAATGTAAAAGTCTtccatcgatacgggt g" /listShort="mpr, ybfJ" /listLong="S87, ybfK, S88, pssA, ybfM, psd" /label="promotor_-35" upshifts 226688 /Source="Nicolas_upshifts" /id="U156" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1104 /SigmaFactorBS="ttgtcatgggacaaggcctgtttttttctttctccgtaaaag ttttATCATAagaatcagaaacctGATTATAATGTAAAAGTCTtccatcgatacgggt g" /listShort="mpr, ybfJ" /listLong="S87, ybfK, S88, pssA, ybfM, psd" /label="upshifts" promotor_-10 226694..226712 /Source="Nicolas_upshift_promotors" /id="U156" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1104 /SigmaFactorBS="ttgtcatgggacaaggcctgtttttttctttctccgtaaaag ttttATCATAagaatcagaaacctGATTATAATGTAAAAGTCTtccatcgatacgggt g" /listShort="mpr, ybfJ" /listLong="S87, ybfK, S88, pssA, ybfM, psd" /label="promotor_-10" promotor_-35 226728..226735 /Source="Nicolas_upshift_promotors" /id="U157" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.390609390609391" /psig=1 /xcortree=760 /SigmaFactorBS="acctgattataatgtaaaagtcttccatcgatacgggtGGTT GACActaaaggagggagaTGACAAAATGAAATTAGTTCcaagattcagaaaacaatgg t" /listShort="mpr, ybfJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 226750..226769 /Source="Nicolas_upshift_promotors" /id="U157" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.390609390609391" /psig=1 /xcortree=760 /SigmaFactorBS="acctgattataatgtaaaagtcttccatcgatacgggtGGTT GACActaaaggagggagaTGACAAAATGAAATTAGTTCcaagattcagaaaacaatgg t" /listShort="mpr, ybfJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 226750 /Source="Nicolas_upshifts" /id="U157" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.390609390609391" /psig=1 /xcortree=760 /SigmaFactorBS="acctgattataatgtaaaagtcttccatcgatacgggtGGTT GACActaaaggagggagaTGACAAAATGAAATTAGTTCcaagattcagaaaacaatgg t" /listShort="mpr, ybfJ" /GFF_Attribute="listLong" /label="upshifts" CDS 226757..227698 /gene="mpr" /locus_tag="BSU_02240" /old_locus_tag="BSU02240" /EC_number="3.4.21.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 15205417, 15375126, 21819557, 25666135; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="extracellular glutamyl-endopeptidase" /protein_id="NP_388106.1" /db_xref="EnsemblGenomes-Gn:BSU02240" /db_xref="EnsemblGenomes-Tr:CAB12018" /db_xref="GOA:P39790" /db_xref="InterPro:IPR000126" /db_xref="InterPro:IPR001254" /db_xref="InterPro:IPR008256" /db_xref="InterPro:IPR009003" /db_xref="InterPro:IPR018114" /db_xref="InterPro:IPR028301" /db_xref="SubtiList:BG10690" /db_xref="UniProtKB/Swiss-Prot:P39790" /translation="MKLVPRFRKQWFAYLTVLCLALAAAVSFGVPAKAAENPQTSVSN TGKEADATKNQTSKADQVSAPYEGTGKTSKSLYGGQTELEKNIQTLQPSSIIGTDERT RISSTTSFPYRATVQLSIKYPNTSSTYGCTGFLVNPNTVVTAGHCVYSQDHGWASTIT AAPGRNGSSYPYGTYSGTMFYSVKGWTESKDTNYDYGAIKLNGSPGNTVGWYGYRTTN SSSPVGLSSSVTGFPCDKTFGTMWSDTKPIRSAETYKLTYTTDTYGCQSGSPVYRNYS DTGQTAIAIHTNGGSSYNLGTRVTNDVFNNIQYWANQ*" /label="mpr CDS" gene 226757..227698 /gene="mpr" /locus_tag="BSU_02240" /old_locus_tag="BSU02240" /label="mpr gene" CDS 227661..228059 /gene="ybfJ" /locus_tag="BSU_02250" /old_locus_tag="BSU02250" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_388107.1" /db_xref="EnsemblGenomes-Gn:BSU02250" /db_xref="EnsemblGenomes-Tr:CAB12019" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR019730" /db_xref="SubtiList:BG12739" /db_xref="UniProtKB/Swiss-Prot:O31451" /translation="MYSTIFNIGQINKYSKLAIFMSILFLCGCSSQTHSSQKETTIPV TLHVEDAKGLPVEGVQVTIVKAPSSDEEPSTEIGEILGKTDKNGDIKWDTGRKGDYSV ALTKGETSVTHHISLTEDKKDHAIPLVFKE*" /label="ybfJ CDS" gene 227661..228059 /gene="ybfJ" /locus_tag="BSU_02250" /old_locus_tag="BSU02250" /label="ybfJ gene" promotor_-10 complement(227753..227767) /Source="Nicolas_upshift_promotors" /id="U158" /multdbtbs="-" /comp="M1" /sig="Sig-" /pcomp="0.418581418581419" /psig="0.418581418581419" /xcortree=776 /SigmaFactorBS="gcagccccttagcatcctccacatgaagagtgacaGGAATAg tcgtttctttttgaGAAGAATGCGTCTGCgaactgcacccgcataaaaacaaaataga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(227763) /Source="Nicolas_upshifts" /id="U158" /multdbtbs="-" /comp="M1" /sig="Sig-" /pcomp="0.418581418581419" /psig="0.418581418581419" /xcortree=776 /SigmaFactorBS="gcagccccttagcatcctccacatgaagagtgacaGGAATAg tcgtttctttttgaGAAGAATGCGTCTGCgaactgcacccgcataaaaacaaaataga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(227783..227788) /Source="Nicolas_upshift_promotors" /id="U158" /multdbtbs="-" /comp="M1" /sig="Sig-" /pcomp="0.418581418581419" /psig="0.418581418581419" /xcortree=776 /SigmaFactorBS="gcagccccttagcatcctccacatgaagagtgacaGGAATAg tcgtttctttttgaGAAGAATGCGTCTGCgaactgcacccgcataaaaacaaaataga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 228046 /Source="Nicolas_upshifts" /id="D85" /incds=0 /nref=19 /ntot=51 /MaxReadThrough="3.50775" /MaxDrop="5.06025" /score="29.4582027" /energy="-15.4" /TU="U156" /idTUdmin="U157" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 228115..228122 /Source="Nicolas_upshift_promotors" /id="U159" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.833166833166833" /psig=1 /xcortree=2185 /SigmaFactorBS="ttttatttattgcaggaaaccaaacTATATACTggaaattta ttatgTGAGATAATAAGAAATAGGTattttttcttacgagacaaaaggggcgttatcc t" /listShort="S87, ybfK, S88, pssA, ybfM, psd" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 228137..228156 /Source="Nicolas_upshift_promotors" /id="U159" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.833166833166833" /psig=1 /xcortree=2185 /SigmaFactorBS="ttttatttattgcaggaaaccaaacTATATACTggaaattta ttatgTGAGATAATAAGAAATAGGTattttttcttacgagacaaaaggggcgttatcc t" /listShort="S87, ybfK, S88, pssA, ybfM, psd" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 228150..228224 /Source="Nicolas_S_feature" /locus_tag="new_246583_246657" /HighExp="Cold, LoTm, S0, aero, ferm, T-4.40H, nit, T-5.40H, T-0.40H, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig="0.973" /label="S87" upshifts 228150 /Source="Nicolas_upshifts" /id="U159" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.833166833166833" /psig=1 /xcortree=2185 /SigmaFactorBS="ttttatttattgcaggaaaccaaacTATATACTggaaattta ttatgTGAGATAATAAGAAATAGGTattttttcttacgagacaaaaggggcgttatcc t" /listShort="S87, ybfK, S88, pssA, ybfM, psd" /GFF_Attribute="listLong" /label="upshifts" CDS 228225..229115 /gene="cesB" /locus_tag="BSU_02260" /old_locus_tag="BSU02260" /EC_number="3.1.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11389736, 24418394" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11389736, 24418394; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enantioselective carboxylesterase" /protein_id="NP_388108.1" /db_xref="EnsemblGenomes-Gn:BSU02260" /db_xref="EnsemblGenomes-Tr:CAB12020" /db_xref="GOA:O31452" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="PDB:4CCY" /db_xref="SubtiList:BG12740" /db_xref="UniProtKB/Swiss-Prot:O31452" /translation="MIQDSMQFAAVESGLRFYQAYDQSLSLWPIESEAFYVSTRFGKT HIIASGPKDAPSLILLHGGLFSSAMWYPNIAAWSSQFRTYAVDIIGDKNKSIPSAAME TRADFAEWMKDVFDSLGLETAHLAGLSLGGSHIVNFLLRAPERVERAVVISPAEAFIS FHPDVYKYAAELTGARGAESYIKWITGDSYDLHPLLQRQIVAGVEWQDEQRSLKPTEN GFPYVFTDQELKSIQVPVLLMFGEHEAMYHQQMAFERASVLVPGIQAEIVKNAGHLLS LEQPEYVNQRVLSFLCGGIK*" /label="cesB CDS" gene 228225..229115 /gene="cesB" /locus_tag="BSU_02260" /old_locus_tag="BSU02260" /label="cesB gene" promotor_-35 228459..228466 /Source="Nicolas_upshift_promotors" /id="U160" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.867132867132867" /psig="0.867132867132867" /xcortree=2736 /SigmaFactorBS="ttttcagctctgcgatgtggtatccgaatatcgcagcgtgga gcAGTCAATTtcgtacatatgcgGTCGATATAATAGGAGACAaaaataaaagtatacc a" /listShort="S88, pssA, ybfM, psd" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 228475 /Source="Nicolas_upshifts" /id="U160" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.867132867132867" /psig="0.867132867132867" /xcortree=2736 /SigmaFactorBS="ttttcagctctgcgatgtggtatccgaatatcgcagcgtgga gcAGTCAATTtcgtacatatgcgGTCGATATAATAGGAGACAaaaataaaagtatacc a" /listShort="S88, pssA, ybfM, psd" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 228480..228498 /Source="Nicolas_upshift_promotors" /id="U160" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.867132867132867" /psig="0.867132867132867" /xcortree=2736 /SigmaFactorBS="ttttcagctctgcgatgtggtatccgaatatcgcagcgtgga gcAGTCAATTtcgtacatatgcgGTCGATATAATAGGAGACAaaaataaaagtatacc a" /listShort="S88, pssA, ybfM, psd" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 229116..229310 /Source="Nicolas_S_feature" /locus_tag="new_247549_247743" /HighExp="Cold, LBGstat, Paraq, Oxctl, H2O2, dia15, G135, Diami, Lbexp, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA" /TUshortPSig="0.867, 1" /TUlongSig="SigEF" /TUlongPSig="0.973" /label="S88" CDS 229311..229844 /gene="pssA" /locus_tag="BSU_02270" /old_locus_tag="BSU02270" /EC_number="2.7.8.8" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14762009, 15743965, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14762009, 15743965, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphatidylserine synthase" /protein_id="NP_388109.1" /db_xref="EnsemblGenomes-Gn:BSU02270" /db_xref="EnsemblGenomes-Tr:CAB12021" /db_xref="GOA:P39823" /db_xref="InterPro:IPR000462" /db_xref="InterPro:IPR004533" /db_xref="SubtiList:BG11012" /db_xref="UniProtKB/Swiss-Prot:P39823" /translation="MNYIPCMITIGNFICGLLAIHSLLYHNIHSAVLFIFTGMFLDFF DGMAARKLNAVSDMGRELDSFADLVTFGVAPSMLAYSVALYTLPFIGILCALTYSICG MLRLSKFNIEQSKLPTFIGMPIPFAGMCLVILSFTYNPILLAIGTCGLSYLMVSKIKF PHFKKHAAENLESGRWN*" /label="pssA CDS" gene 229311..229844 /gene="pssA" /locus_tag="BSU_02270" /old_locus_tag="BSU02270" /label="pssA gene" CDS 229835..230323 /gene="ybfM" /locus_tag="BSU_02280" /old_locus_tag="BSU02280" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12682299, 14762009, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane phosphatase" /protein_id="NP_388110.1" /db_xref="EnsemblGenomes-Gn:BSU02280" /db_xref="EnsemblGenomes-Tr:CAB12022" /db_xref="GOA:O31453" /db_xref="InterPro:IPR032816" /db_xref="SubtiList:BG12741" /db_xref="UniProtKB/Swiss-Prot:O31453" /translation="MELVQQLIADYGYLAIFLMLVLGIVGLPIPDEVMMTVVGYFTHT DVLNYELSILISFVGALLGMLISYMIGRKAGRPFIDKYGKWVGLKEKRMMKVEKWMKK YGPYSLILGYFIPGVRHVTCYFSGIGKMDLKTYVAFAAIGAFLWCFVFITIGRVIGII HV*" /label="ybfM CDS" gene 229835..230323 /gene="ybfM" /locus_tag="BSU_02280" /old_locus_tag="BSU02280" /label="ybfM gene" CDS 230316..231107 /gene="psd" /locus_tag="BSU_02290" /old_locus_tag="BSU02290" /EC_number="4.1.1.65" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 14762009, 9422599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14762009, 9422599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphatidylserine decarboxylase; 32 kDa precursor processed into a 29 kDa protein" /protein_id="NP_388111.1" /db_xref="EnsemblGenomes-Gn:BSU02290" /db_xref="EnsemblGenomes-Tr:CAB12023" /db_xref="GOA:P39822" /db_xref="InterPro:IPR003817" /db_xref="InterPro:IPR033177" /db_xref="InterPro:IPR033178" /db_xref="SubtiList:BG11013" /db_xref="UniProtKB/Swiss-Prot:P39822" /translation="MFNTAVKILYRSLIELTNHRLSSYLIKGFCESKISKPVIPLFSK HFRLNWDDVDGTAADYGSLSELFIRQINLERRPVSKEAHAVVSPVDGVVQTVGIINPN QTFTVKGKDYSFAELTGCKSADHQYNGGYFVVLYLSPRHYHRFHSPISCRYQKLAELG NRSYPVNQLGLKYGKDVLSKNYRFVYELNSGSRNVLMIPVGAMNINSIVQTNTRTELE IGEELGYFSFGSTVILVFEKDAFQPSAHLAEGQEVQVGELIGYEE*" /label="psd CDS" gene 230316..231107 /gene="psd" /locus_tag="BSU_02290" /old_locus_tag="BSU02290" /label="psd gene" downshifts 231082 /Source="Nicolas_upshifts" /id="D86" /incds=0 /nref=101 /ntot=236 /MaxReadThrough="3.18138" /MaxDrop="4.25536" /score="-2.98360164" /energy="-8" /TU="U159" /idTUdmin="U160" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 231162..231440 /gene="ybfN" /locus_tag="BSU_02300" /old_locus_tag="BSU02300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388112.1" /db_xref="EnsemblGenomes-Gn:BSU02300" /db_xref="EnsemblGenomes-Tr:CAB12024" /db_xref="SubtiList:BG12742" /db_xref="UniProtKB/Swiss-Prot:O31454" /translation="MEKQIISWITDYQNTGDEAVLRQVREVCWPIVEAVLQEKVMDDE QANNLREKGIERFPFIISKYQADVQLPVETFLQNTYRFYFHQVMRESS*" /label="ybfN CDS" gene 231162..231440 /gene="ybfN" /locus_tag="BSU_02300" /old_locus_tag="BSU02300" /label="ybfN gene" promotor_-35 231483..231492 /Source="Nicolas_upshift_promotors" /id="U161" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1688 /SigmaFactorBS="agcttctttcaacagagaagcttttttttgttggcaggaaaa GGAAACTTTTtctatatctatcTCGTAATGACTAGAGAacctagcagaaaaggagaga t" /listShort="ybfO, ybfP, S89, ybfQ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 231501 /Source="Nicolas_upshifts" /id="U161" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1688 /SigmaFactorBS="agcttctttcaacagagaagcttttttttgttggcaggaaaa GGAAACTTTTtctatatctatcTCGTAATGACTAGAGAacctagcagaaaaggagaga t" /listShort="ybfO, ybfP, S89, ybfQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 231505..231520 /Source="Nicolas_upshift_promotors" /id="U161" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1688 /SigmaFactorBS="agcttctttcaacagagaagcttttttttgttggcaggaaaa GGAAACTTTTtctatatctatcTCGTAATGACTAGAGAacctagcagaaaaggagaga t" /listShort="ybfO, ybfP, S89, ybfQ" /GFF_Attribute="listLong" /label="promotor_-10" CDS 231546..232886 /gene="ybfO" /locus_tag="BSU_02310" /old_locus_tag="BSU02310" /EC_number="3.-.-.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative exported hydrolase" /protein_id="NP_388113.1" /db_xref="EnsemblGenomes-Gn:BSU02310" /db_xref="EnsemblGenomes-Tr:CAB12025" /db_xref="GOA:O31455" /db_xref="InterPro:IPR007815" /db_xref="SubtiList:BG12743" /db_xref="UniProtKB/Swiss-Prot:O31455" /translation="MKRMIVRMTLPLLIVCLAFSSFSASARAASEEKYWDHWIERHAQ PLDASNASNKDLRFLKKVLKGKRIVQLGETTHGAGEINATKVRMIKYLHEELGYDVLA FESGFPDTNASYLNMDQLTPKSTMKNSIYAVWHTEDVVELFDYMKEQKEKGDPLILTG FDIQSMKNSFNVAATQWVKAVDPEKAELLSQSENDFSTLVTDSNTFDEFSQKKEKLVK NYQKLIKFTKTHASELKENLPKEPKAYEMFMHSLQLRIDVMETYMLEEMKEKLEEYPE NIEDFSFFMRDRMMAEQFQWVADTLYPKKKIIVWGHNYHLRKQNTKMIKDWVQLNGPN MGDYLPERLKKQTYTIGIYAYSGASLDSSDNKTVKPVTSPPPSGSLEALLKAADRPAV FVDFLHTKNKKGTSWMYTPRTALYWGYMEEQMILKEQYDGVIWLEHITPSVIIK*" /label="ybfO CDS" gene 231546..232886 /gene="ybfO" /locus_tag="BSU_02310" /old_locus_tag="BSU02310" /label="ybfO gene" downshifts 232886 /Source="Nicolas_upshifts" /id="D87" /incds=0 /nref=12 /ntot=60 /MaxReadThrough="3.64301" /MaxDrop="6.34998" /score="14.4442651" /energy="-13.3" /TU="U161" /idTUdmin="U162" /TUdmin="-1122" /isTUend="FALSE" /label="downshifts" upshifts 232952 /Source="Nicolas_upshifts" /id="U162" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.582417582417582" /psig="0.838161838161838" /xcortree=1579 /SigmaFactorBS="gtcccctgtggtaaacaggggatttttacatatcgcaaaaat aatcaaaacatataatccgtgATCCATTATTCTAAAACAGAaaggagattggagcgtg c" /listShort="ybfP, S89" /listLong="ybfQ" /label="upshifts" misc_feature 232955..232974 /Source="Nicolas_upshift_promotors" /id="U162" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.582417582417582" /psig="0.838161838161838" /xcortree=1579 /SigmaFactorBS="gtcccctgtggtaaacaggggatttttacatatcgcaaaaat aatcaaaacatataatccgtgATCCATTATTCTAAAACAGAaaggagattggagcgtg c" /listShort="ybfP, S89" /listLong="ybfQ" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 232994..233881 /gene="ybfP" /locus_tag="BSU_02320" /old_locus_tag="BSU02320" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (AraC/XylS family)" /protein_id="NP_388114.1" /db_xref="EnsemblGenomes-Gn:BSU02320" /db_xref="EnsemblGenomes-Tr:CAB12026" /db_xref="GOA:O31456" /db_xref="InterPro:IPR008979" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR018060" /db_xref="SubtiList:BG12744" /db_xref="UniProtKB/Swiss-Prot:O31456" /translation="MYYEKAVQKTINWIESHLHEQISNEDIVNVSSFSKFHFHRIFQK EVGMSVASYIRLRRLANAAAALLYTDHRIIDIALYYQFESQEAFTRTFKKMYHMPPGA YRTFMKRFTSKKEESYMEKKMKGWVLSGSHPFQFEMGIDRENVHQGKASGYLKSTMVQ DIGEFATMMQQFKADRYLGKRLRLSSFIKTKGVQHFASLWMRVDSAADDVLQFDNMSN RPITGTTNWNHYAIVLDVPENSAVISFGVQLSGPGQVWMDHVVFEEVDESVPSTNLEM PGELLDEPVNLSFEEELQK*" /label="ybfP CDS" gene 232994..233881 /gene="ybfP" /locus_tag="BSU_02320" /old_locus_tag="BSU02320" /label="ybfP gene" S_feature 233882..234025 /Source="Nicolas_S_feature" /locus_tag="new_252315_252458" /HighExp="T0.30H, T-1.40H, T0.0H, T-1.10H, Salt, aero, ferm, T-0.40H, T-2.40H, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY" /TUshortPSig="0.838, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S89" promotor_-35 233997..234004 /Source="Nicolas_upshift_promotors" /id="U163" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2069 /SigmaFactorBS="gcttggatatttttatcagtctgggcggatCTGTTCATcttt gcggcatttTCCTGTATGATATAGTAAGAgtgtgcatagcaactaactataattgaac a" /listShort="ybfQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 234018..234037 /Source="Nicolas_upshift_promotors" /id="U163" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2069 /SigmaFactorBS="gcttggatatttttatcagtctgggcggatCTGTTCATcttt gcggcatttTCCTGTATGATATAGTAAGAgtgtgcatagcaactaactataattgaac a" /listShort="ybfQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 234027 /Source="Nicolas_upshifts" /id="U163" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2069 /SigmaFactorBS="gcttggatatttttatcagtctgggcggatCTGTTCATcttt gcggcatttTCCTGTATGATATAGTAAGAgtgtgcatagcaactaactataattgaac a" /listShort="ybfQ" /GFF_Attribute="listLong" /label="upshifts" CDS 234081..235049 /gene="ybfQ" /locus_tag="BSU_02330" /old_locus_tag="BSU02330" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10939241, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme with rhodanese domain" /protein_id="NP_388115.1" /db_xref="EnsemblGenomes-Gn:BSU02330" /db_xref="EnsemblGenomes-Tr:CAB12027" /db_xref="InterPro:IPR001763" /db_xref="InterPro:IPR020936" /db_xref="InterPro:IPR022111" /db_xref="InterPro:IPR036873" /db_xref="SubtiList:BG12745" /db_xref="UniProtKB/Swiss-Prot:O31457" /translation="MEKQYRVLLYYKYVPIEDPEAFREQHLAFCKELGLLGRILVSSE GINGTVSGTVEQTEKYMETMKADPRFADMVFKIDEAEGHAFKKIFVRHKKELVTLRLE DDVDPNETTGQHLKPAEFYEKMQDPNTIVIDARNDYEYDLGHFRGAVRPDIEAFRELP EWIEEHKDMLEGKKILTYCTGGVRCEKFSGWLVKQGFEDVAQLDGGIVTYGKDPEVQG KLWDGQCYVFDERISVPVNRVEHVIVGKDYFTGEPCERYVNCANPSCNKKMICTPENE YKYMRSCSHECRTNPRNLYVKEHNMTEEEVNARLAAIETEDHAAAE*" /label="ybfQ CDS" gene 234081..235049 /gene="ybfQ" /locus_tag="BSU_02330" /old_locus_tag="BSU02330" /label="ybfQ gene" promotor_-10 complement(234903..234921) /Source="Nicolas_upshift_promotors" /id="U164" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=798 /SigmaFactorBS="attatgctctttcacatacaggtttcttgggttcgtgcGGCA TTcgtggctgcagctgcGCATATATTTATACTCATTttccggtgtgcatatcattttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(234920) /Source="Nicolas_upshifts" /id="U164" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=798 /SigmaFactorBS="attatgctctttcacatacaggtttcttgggttcgtgcGGCA TTcgtggctgcagctgcGCATATATTTATACTCATTttccggtgtgcatatcattttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(234937..234942) /Source="Nicolas_upshift_promotors" /id="U164" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=798 /SigmaFactorBS="attatgctctttcacatacaggtttcttgggttcgtgcGGCA TTcgtggctgcagctgcGCATATATTTATACTCATTttccggtgtgcatatcattttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 235046 /Source="Nicolas_upshifts" /id="D88" /incds=0 /nref=238 /ntot=271 /MaxReadThrough="2.06825" /MaxDrop="7.49655" /score="4.11635522" /energy="-7.8" /TU="U163" /idTUdmin="U161" /TUdmin=4 /isTUend="TRUE" /label="downshifts" downshifts complement(235085) /Source="Nicolas_upshifts" /id="D89" /incds=0 /nref=59 /ntot=147 /MaxReadThrough="0.54212" /MaxDrop="6.33244" /score="2.56774646" /energy="-7.5" /TU="NA" /idTUdmin="U165" /TUdmin=11 /isTUend="TRUE" /label="downshifts" CDS complement(235085..236329) /gene="gltP" /locus_tag="BSU_02340" /old_locus_tag="BSU02340" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7751298, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7751298, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="proton/glutamate symport protein" /protein_id="NP_388116.1" /db_xref="EnsemblGenomes-Gn:BSU02340" /db_xref="EnsemblGenomes-Tr:CAB12028" /db_xref="GOA:P39817" /db_xref="InterPro:IPR001991" /db_xref="InterPro:IPR018107" /db_xref="InterPro:IPR033380" /db_xref="InterPro:IPR036458" /db_xref="SubtiList:BG11015" /db_xref="UniProtKB/Swiss-Prot:P39817" /translation="MKKLIAFQILIALAVGAVIGHFFPDFGMALRPVGDGFIRLIKMI VVPIVFSTIVIGAAGSGSMKKMGSLGIKTIIWFEVITTLVLGLGLLLANVLKPGVGLD LSHLAKKDIHELSGYTDKVVDFKQMILDIIPTNIIDVMARNDLLAVIFFAILFGVAAA GIGKASEPVMKFFESTAQIMFKLTQIVMVTAPIGVLALMAASVGQYGIELLLPMFKLV GTVFLGLFLILFVLFPLVGLIFQIKYFEVLKMIWDLFLIAFSTTSTETILPQLMDRME KYGCPKRVVSFVVPSGLSLNCDGSSLYLSVSCIFLAQAFQVDMTLSQQLLMMLVLVMT SKGIAAVPSGSLVVLLATANAVGLPAEGVAIIAGVDRVMDMARTGVNVPGHAIACIVV SKWEKAFRQKEWVSANSQTESI*" /label="gltP CDS" gene complement(235085..236329) /gene="gltP" /locus_tag="BSU_02340" /old_locus_tag="BSU02340" /label="gltP gene" promotor_-10 complement(236363..236381) /Source="Nicolas_upshift_promotors" /id="U165" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=525 /SigmaFactorBS="tgaaagcgctgtcaaaataaaataacttgaaaAAAGGTGTTt gcatttgaaTCACGAATGATATGAATATgcctacattctatcgttctaaagggggatt c" /listShort="gltP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(236372) /Source="Nicolas_upshifts" /id="U165" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=525 /SigmaFactorBS="tgaaagcgctgtcaaaataaaataacttgaaaAAAGGTGTTt gcatttgaaTCACGAATGATATGAATATgcctacattctatcgttctaaagggggatt c" /listShort="gltP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(236392..236400) /Source="Nicolas_upshift_promotors" /id="U165" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=525 /SigmaFactorBS="tgaaagcgctgtcaaaataaaataacttgaaaAAAGGTGTTt gcatttgaaTCACGAATGATATGAATATgcctacattctatcgttctaaagggggatt c" /listShort="gltP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(236400..236418) /Source="Nicolas_upshift_promotors" /id="U166" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.949050949050949" /psig="0.949050949050949" /xcortree=797 /SigmaFactorBS="taaaaaagtcccccctgctgcgggggactttttcgccAACAT AatgaaagcgctgtcaAAATAAAATAACTTGAAAAaaggtgtttgcatttgaatcacg a" /listShort="gltP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(236416) /Source="Nicolas_upshifts" /id="U166" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.949050949050949" /psig="0.949050949050949" /xcortree=797 /SigmaFactorBS="taaaaaagtcccccctgctgcgggggactttttcgccAACAT AatgaaagcgctgtcaAAATAAAATAACTTGAAAAaaggtgtttgcatttgaatcacg a" /listShort="gltP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(236434..236439) /Source="Nicolas_upshift_promotors" /id="U166" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.949050949050949" /psig="0.949050949050949" /xcortree=797 /SigmaFactorBS="taaaaaagtcccccctgctgcgggggactttttcgccAACAT AatgaaagcgctgtcaAAATAAAATAACTTGAAAAaaggtgtttgcatttgaatcacg a" /listShort="gltP" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(236474..238369) /gene="gamP" /locus_tag="BSU_02350" /old_locus_tag="BSU02350" /EC_number="2.7.1.193" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10627040, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) glucosamine-specific enzyme IICBA component" /protein_id="NP_388117.1" /db_xref="EnsemblGenomes-Gn:BSU02350" /db_xref="EnsemblGenomes-Tr:CAB12029" /db_xref="GOA:P39816" /db_xref="InterPro:IPR001127" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR011055" /db_xref="InterPro:IPR011299" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG11014" /db_xref="UniProtKB/Swiss-Prot:P39816" /translation="MFKKAFQILQQLGRALMTPVAVLPAAGLLLRFGDKDLLNIPIIK DAGGVVFDNLPLIFAVGVAIGLAGGEGVAGLAAVIGYLILTVTLDNMGKLLGLQPPYE GAEHLIDMGVFGGIIIGLLAAYLYKRFSSIELHPVLGFFSGKRFVPIITSVSSLVIGV IFSFVWPLIQNGINAASSLIADSTVGLFFYATIYRLLIPFGLHHIFYTPFYFMMGEYT DPSTGNTVTGDLTRFFAGDPTAGRFMMGDFPYMIFCLPAVALAIIHTARPEKKKMISG VMISAALTSMLTGITEPVEFSFLFVAPVLYLINSILAGVIFVVCDLFHVRHGYTFSGG GIDYVLNYGLSTNGWVVIPVGIVFAFIYYYLFRFAILKWNLKTPGRETDEDGQNEEKA PVAKDQLAFHVLQALGGQQNIANLDACITRLRVTVHQPSQVCKDELKRLGAVGVLEVN NNFQAIFGTKSDALKDDIKTIMAGGVPATAAALDTVTDKPLKPDSDETFIYPIKGETV SLGDVPDQVFSEKMMGEGFAIIPSEGKVVAPADGEIVSIFPTKHAIGFMSAGGTEILI HVGIDTVKLNGEGFEAHVTSGQAVKQGELLLTFDLNYIKQHAASAITPVIFTNTSEED LKHIQMK*" /label="gamP CDS" gene complement(236474..238369) /gene="gamP" /locus_tag="BSU_02350" /old_locus_tag="BSU02350" /label="gamP gene" downshifts complement(236490) /Source="Nicolas_upshifts" /id="D90" /incds=0 /nref=56 /ntot=192 /MaxReadThrough="1.9947" /MaxDrop="6.51864" /score="5.87664177" /energy="-12.1" /TU="NA" /idTUdmin="U168" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" misc_feature 238235..238254 /Source="Nicolas_upshift_promotors" /id="U167" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.701298701298701" /psig="0.975024975024975" /xcortree=2747 /SigmaFactorBS="cggcgaaaatcagcggaaggttatcgaatacaacgccgcccg cATCCTTTATAATAGGGATGTtcagtaaatccttgtctccgaaacggagcaaaagacc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 238252 /Source="Nicolas_upshifts" /id="U167" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.701298701298701" /psig="0.975024975024975" /xcortree=2747 /SigmaFactorBS="cggcgaaaatcagcggaaggttatcgaatacaacgccgcccg cATCCTTTATAATAGGGATGTtcagtaaatccttgtctccgaaacggagcaaaagacc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(238390..239139) /gene="gamA" /locus_tag="BSU_02360" /old_locus_tag="BSU02360" /EC_number="3.5.99.6" /function="16.11: Scavenge (Catabolism)" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:23667565, 27002132" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23667565, 27002132; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucosamine-6-phosphate deaminase" /protein_id="NP_388118.1" /db_xref="EnsemblGenomes-Gn:BSU02360" /db_xref="EnsemblGenomes-Tr:CAB12030" /db_xref="GOA:O31458" /db_xref="InterPro:IPR004547" /db_xref="InterPro:IPR006148" /db_xref="InterPro:IPR018321" /db_xref="SubtiList:BG12746" /db_xref="UniProtKB/Swiss-Prot:O31458" /translation="MKILIAEHYEELCKLSAAIIKEQIQAKKDAVLGLATGSTPVGLY KQLISDYQAGEIDFSKVTTFNLDEYAGLSPSHPQSYNHFMHEHLFQHINMQPDHIHIP QGDNPQLEAACKVYEDLIRQAGGIDVQILGIGANGHIGFNEPGSDFEDRTRVVKLSES TIQANARFFGGDPVLVPRLAISMGIKTIMEFSKHIVLLASGEEKADAIQKMAEGPVTT DVPASILQKHNHVTVIADYKAAQKLKSASFS*" /label="gamA CDS" gene complement(238390..239139) /gene="gamA" /locus_tag="BSU_02360" /old_locus_tag="BSU02360" /label="gamA gene" S_feature 239112..239293 /Source="Nicolas_S_feature" /locus_tag="new_257545_257726" /HighExp="H2O2, T1.30H, G135, dia15, G150, G180, LBGstat, T2.0H, T0.30H, M9-stat" /AntisenseName="nagBB" /AntisenseCor="0.458837556034909" /AntisenseRegPval="-14.7" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S90" S_feature complement(239140..239210) /Source="Nicolas_S_feature" /locus_tag="new_257573_257643_c" /HighExp="S1, Diami, MG 5, MG t5, dia5, MG 15, MG 10, LPhT, Paraq, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S91" promotor_-10 complement(239199..239218) /Source="Nicolas_upshift_promotors" /id="U168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2202 /SigmaFactorBS="atccttcttttataacaaattttcagaaattaaTATTGACAg tttgataagggcggTGCTAAATTCGTAATGACAAgtatcataaattggtcataacaaa t" /listShort="S91, nagBB, nagP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(239214) /Source="Nicolas_upshifts" /id="U168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2202 /SigmaFactorBS="atccttcttttataacaaattttcagaaattaaTATTGACAg tttgataagggcggTGCTAAATTCGTAATGACAAgtatcataaattggtcataacaaa t" /listShort="S91, nagBB, nagP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(239234..239241) /Source="Nicolas_upshift_promotors" /id="U168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2202 /SigmaFactorBS="atccttcttttataacaaattttcagaaattaaTATTGACAg tttgataagggcggTGCTAAATTCGTAATGACAAgtatcataaattggtcataacaaa t" /listShort="S91, nagBB, nagP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 239280..239287 /Source="Nicolas_upshift_promotors" /id="U169" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.662337662337662" /psig=1 /xcortree=1865 /SigmaFactorBS="gtcaatattaatttctgaaaatttgttataaaagaaggatac aaaTCTTTCATattgggagggcaAATGGTATTATGGTCTCAATgaaaaagaacggatt g" /listShort="ybgA, ybgB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 239295 /Source="Nicolas_upshifts" /id="U169" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.662337662337662" /psig=1 /xcortree=1865 /SigmaFactorBS="gtcaatattaatttctgaaaatttgttataaaagaaggatac aaaTCTTTCATattgggagggcaAATGGTATTATGGTCTCAATgaaaaagaacggatt g" /listShort="ybgA, ybgB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 239300..239319 /Source="Nicolas_upshift_promotors" /id="U169" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.662337662337662" /psig=1 /xcortree=1865 /SigmaFactorBS="gtcaatattaatttctgaaaatttgttataaaagaaggatac aaaTCTTTCATattgggagggcaAATGGTATTATGGTCTCAATgaaaaagaacggatt g" /listShort="ybgA, ybgB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 239358..240065 /gene="gamR" /locus_tag="BSU_02370" /old_locus_tag="BSU02370" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:23667565, 24673833" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23667565, 24673833; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator-GlcN6P (GntR family)" /protein_id="NP_388119.1" /db_xref="EnsemblGenomes-Gn:BSU02370" /db_xref="EnsemblGenomes-Tr:CAB12031" /db_xref="GOA:O31459" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR011663" /db_xref="InterPro:IPR028978" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12747" /db_xref="UniProtKB/Swiss-Prot:O31459" /translation="MTALYSVIKFKIIELIKSGKYQANDQLPTESEFCEQYDVSRTTV RLALQQLELEGYIKRIQGKGTFVSAAKIQTPIPHKITSFAEQMRGLRSESKVLELVVI PADHSIAELLKMKENEPVNKLVRVRYAEGEPLQYHTSYIPWKAAPGLAQEECTGSLFE LLRTKYNIEISRGTESIEPILTDETISGHLLTNVGAPAFLSESLTYDKNEEVVEYAQI ITRGDRTKFTVEQSYHS*" /label="gamR CDS" gene 239358..240065 /gene="gamR" /locus_tag="BSU_02370" /old_locus_tag="BSU02370" /label="gamR gene" promotor_-35 240031..240032 /Source="Nicolas_upshift_promotors" /id="U170" /multdbtbs="SigY" /comp="M9" /sig="Sig-" /pcomp="0.41958041958042" /psig="0.41958041958042" /xcortree=1684 /SigmaFactorBS="aatatgcgcaaattattacacggggagaccgaaCGaaattca ccgtagaaCAGTCATATCATTCAtaaagcaatgtgttttaagaagggaatggtggttc t" /listShort="ybgB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 240048..240062 /Source="Nicolas_upshift_promotors" /id="U170" /multdbtbs="SigY" /comp="M9" /sig="Sig-" /pcomp="0.41958041958042" /psig="0.41958041958042" /xcortree=1684 /SigmaFactorBS="aatatgcgcaaattattacacggggagaccgaaCGaaattca ccgtagaaCAGTCATATCATTCAtaaagcaatgtgttttaagaagggaatggtggttc t" /listShort="ybgB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 240058 /Source="Nicolas_upshifts" /id="U170" /multdbtbs="SigY" /comp="M9" /sig="Sig-" /pcomp="0.41958041958042" /psig="0.41958041958042" /xcortree=1684 /SigmaFactorBS="aatatgcgcaaattattacacggggagaccgaaCGaaattca ccgtagaaCAGTCATATCATTCAtaaagcaatgtgttttaagaagggaatggtggttc t" /listShort="ybgB" /GFF_Attribute="listLong" /label="upshifts" CDS 240099..240374 /gene="ybgB" /locus_tag="BSU_02380" /old_locus_tag="BSU02380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12897008, 23667565" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (B. subtilis-specific)" /protein_id="NP_388120.1" /db_xref="EnsemblGenomes-Gn:BSU02380" /db_xref="EnsemblGenomes-Tr:CAB12032" /db_xref="GOA:O31460" /db_xref="InterPro:IPR012867" /db_xref="SubtiList:BG12748" /db_xref="UniProtKB/Swiss-Prot:O31460" /translation="MFLFTNGKVLWGAVIAAFILSIVFYPFLPTQMPIHYDVANSPDL TVNKLAGTVMLPVLMVVFAWARKINWQFVFAVYILLICHIVVLCLAL*" /label="ybgB CDS" gene 240099..240374 /gene="ybgB" /locus_tag="BSU_02380" /old_locus_tag="BSU02380" /label="ybgB gene" promotor_-10 complement(240157..240175) /Source="Nicolas_upshift_promotors" /id="U171" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=112 /SigmaFactorBS="ggactgttcgcaacatcataatgaatcGGCATCTgcgtcggc agaaaaGGGTAAAATACAATTGAAAggatgaatgcagcaatcactgctccccacagca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(240163) /Source="Nicolas_upshifts" /id="U171" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=112 /SigmaFactorBS="ggactgttcgcaacatcataatgaatcGGCATCTgcgtcggc agaaaaGGGTAAAATACAATTGAAAggatgaatgcagcaatcactgctccccacagca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(240190..240196) /Source="Nicolas_upshift_promotors" /id="U171" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=112 /SigmaFactorBS="ggactgttcgcaacatcataatgaatcGGCATCTgcgtcggc agaaaaGGGTAAAATACAATTGAAAggatgaatgcagcaatcactgctccccacagca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 240366 /Source="Nicolas_upshifts" /id="D91" /incds=0 /nref=20 /ntot=130 /MaxReadThrough="2.42422" /MaxDrop="3.75723" /score="4.58454735" /energy="-9.4" /TU="NA" /idTUdmin="U169" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 240417..240421 /Source="Nicolas_upshift_promotors" /id="U172" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.641358641358641" /psig="0.998001998001998" /xcortree=2879 /SigmaFactorBS="gccagaataaaactggctgttttctttaatttcaGCTTCatc tgacaatgaatgTGGTGTATAATAGCTGATGAtcctaaagaatattctgaaatttata g" /listShort="S92, ilvE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 240437..240456 /Source="Nicolas_upshift_promotors" /id="U172" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.641358641358641" /psig="0.998001998001998" /xcortree=2879 /SigmaFactorBS="gccagaataaaactggctgttttctttaatttcaGCTTCatc tgacaatgaatgTGGTGTATAATAGCTGATGAtcctaaagaatattctgaaatttata g" /listShort="S92, ilvE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 240443 /Source="Nicolas_upshifts" /id="U172" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.641358641358641" /psig="0.998001998001998" /xcortree=2879 /SigmaFactorBS="gccagaataaaactggctgttttctttaatttcaGCTTCatc tgacaatgaatgTGGTGTATAATAGCTGATGAtcctaaagaatattctgaaatttata g" /listShort="S92, ilvE" /GFF_Attribute="listLong" /label="upshifts" S_feature 240454..240582 /Source="Nicolas_S_feature" /locus_tag="new_258887_259015" /HighExp="T2.30H, S5, T2.0H, T1.30H, M9-stat, T3.0H, T3.30H, S4, T1.0H, T-0.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S92" CDS 240583..241653 /gene="ilvE" /locus_tag="BSU_02390" /old_locus_tag="BSU02390" /EC_number="2.6.1.42" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12670965, 15060025, 15102328, 20332210, 23429746" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12670965, 15060025, 15102328, 20332210, 23429746; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isoleucine-valine aminotransferase / aromatic amino acid aminotransferase" /protein_id="NP_388121.1" /db_xref="EnsemblGenomes-Gn:BSU02390" /db_xref="EnsemblGenomes-Tr:CAB12033" /db_xref="GOA:O31461" /db_xref="InterPro:IPR001544" /db_xref="InterPro:IPR005786" /db_xref="InterPro:IPR018300" /db_xref="InterPro:IPR033939" /db_xref="InterPro:IPR036038" /db_xref="SubtiList:BG12749" /db_xref="UniProtKB/Swiss-Prot:O31461" /translation="MNKLIEREKTVYYKEKPDPSSLGFGQYFTDYMFVMDYEEGIGWH HPRIAPYAPLTLDPSSSVFHYGQAVFEGLKAYRTDDGRVLLFRPDQNIKRLNRSCERM SMPPLDEELVLEALTQLVELEKDWVPKEKGTSLYIRPFVIATEPSLGVKASRSYTFMI VLSPVGSYYGDDQLKPVRIYVEDEYVRAVNGGVGFAKTAGNYAASLQAQRKANELGYD QVLWLDAIEKKYVEEVGSMNIFFVINGEAVTPALSGSILSGVTRASAIELIRSWGIPV REERISIDEVYAASARGELTEVFGTGTAAVVTPVGELNIHGKTVIVGDGQIGDLSKKL YETITDIQLGKVKGPFNWTVEV*" /label="ilvE CDS" gene 240583..241653 /gene="ilvE" /locus_tag="BSU_02390" /old_locus_tag="BSU02390" /label="ilvE gene" downshifts 241642 /Source="Nicolas_upshifts" /id="D92" /incds=0 /nref=124 /ntot=245 /MaxReadThrough="1.34575" /MaxDrop="6.88046" /score="13.1364544" /energy="-9.4" /TU="NA" /idTUdmin="U172" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(241690..243102) /gene="ybgF" /locus_tag="BSU_02400" /old_locus_tag="BSU02400" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7704263, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative aminoacid permease" /protein_id="NP_388122.1" /db_xref="EnsemblGenomes-Gn:BSU02400" /db_xref="EnsemblGenomes-Tr:CAB12034" /db_xref="GOA:O31462" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG12750" /db_xref="UniProtKB/Swiss-Prot:O31462" /translation="MNSAHNKNETTFQRSMKSRHLFMLSLGGVIGTGLFLSSGYTIQQ AGPAGTILAYLVGAGIVYLVMLCLGELSVAMPVTGAFHTYAAKYIGPGTGFTVAWLYW LTWTVALGSEFTAAGLLMQRWFPHTSVWMWSAVFALFIFLLNAFSVKFFAESEFWFSS IKVLAIVLFILLGGSAMFGIIPIKGGEAAPMLSNFTAEGGLFPNGFVPILMTMLSVNF AFSGTELIGIAAGESVDPDKTIPKAIKTTVWRLSLFFVGTIFVLSGLIPIQDAGVIKS PFVAVFDRVGVPYAADIMNFVILTAILSAANSGLYASSRMLWSLSKEKTLHPTFAKLT SKGTPFNALVFSMIGGILSLLSSVFAPDTVYVVLVSISGFAVVVVWMGIAASQFMFRK RYIEAGNKVTDLKYRTPLYPFVPIAAFLLCLASVVGIAFDPNQRIALYCGVPFMAICY AIYYVKNRKSQPAADMTHSK*" /label="ybgF CDS" gene complement(241690..243102) /gene="ybgF" /locus_tag="BSU_02400" /old_locus_tag="BSU02400" /label="ybgF gene" downshifts complement(241707) /Source="Nicolas_upshifts" /id="D93" /incds=0 /nref=43 /ntot=166 /MaxReadThrough="0.37503" /MaxDrop="5.92001" /score="6.94246417" /energy="-9.4" /TU="NA" /idTUdmin="U173" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" S_feature complement(243103..243214) /Source="Nicolas_S_feature" /locus_tag="new_261536_261647_c" /HighExp="BMM, S1, MG 45, MG 60, UNK1, MG t5, MG 10, MG 90, MG-0.2, M9-exp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.999" /label="S93" promotor_-10 complement(243187..243206) /Source="Nicolas_upshift_promotors" /id="U173" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=3071 /SigmaFactorBS="cgaaaatattcaagaaattgcggcttgggcccgctctttaaa aacaACTTGACTtatcggaatagtttGTATATTCTAACTTAAAGCCggttcgccggag t" /listShort="S93, ybgF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(243214) /Source="Nicolas_upshifts" /id="U173" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=3071 /SigmaFactorBS="cgaaaatattcaagaaattgcggcttgggcccgctctttaaa aacaACTTGACTtatcggaatagtttGTATATTCTAACTTAAAGCCggttcgccggag t" /listShort="S93, ybgF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(243221..243228) /Source="Nicolas_upshift_promotors" /id="U173" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=3071 /SigmaFactorBS="cgaaaatattcaagaaattgcggcttgggcccgctctttaaa aacaACTTGACTtatcggaatagtttGTATATTCTAACTTAAAGCCggttcgccggag t" /listShort="S93, ybgF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(243223..244170) /gene="ybgG" /locus_tag="BSU_02410" /old_locus_tag="BSU02410" /EC_number="2.1.1.10" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11267663, 15995196, 17264075; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="homocysteine methylase using (R,S)AdoMet" /protein_id="NP_388123.1" /db_xref="EnsemblGenomes-Gn:BSU02410" /db_xref="EnsemblGenomes-Tr:CAB12035" /db_xref="GOA:O31463" /db_xref="InterPro:IPR003726" /db_xref="InterPro:IPR017226" /db_xref="InterPro:IPR036589" /db_xref="SubtiList:BG12751" /db_xref="UniProtKB/Swiss-Prot:O31463" /translation="MNPIQHILDTYPLIVLDGAMATELERKGCNLNDSLWSAKILMEE PELIKQVHTDYFAAGADCAITASYQSTFEGFAARGLSEAEARRLIELSVSIAAEARDE FWSLEENRLNRPKPIIAASIGPYGAYLADGSEYRGNYAISEDELIEFHRPRMKALIEA GADVLACETIPCLTEAKAIVRLLKEFPETYAWISFSAKDGLHISDGTPAADCASWLDE HRQIAALGINCTPLQHIPSLIEELKKNTSKPIIVYPNSGEQYDPETKTWNGAACAESY GASARTWHEKGARLIGGCCRTKPENIQEIAAWARSLKTT*" /label="ybgG CDS" gene complement(243223..244170) /gene="ybgG" /locus_tag="BSU_02410" /old_locus_tag="BSU02410" /label="ybgG gene" promotor_-10 complement(244208..244227) /Source="Nicolas_upshift_promotors" /id="U174" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig="0.999000999001" /xcortree=3068 /SigmaFactorBS="agacatatgggctgaacacctttctctttttgcgttTATTGA CAaacacgtaagcctcCATTACGATTTTCATATCTTtttcaaaaaaatctgaaagaag g" /listShort="ybgG" /listLong="S93, ybgF" /label="promotor_-10" upshifts complement(244225) /Source="Nicolas_upshifts" /id="U174" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig="0.999000999001" /xcortree=3068 /SigmaFactorBS="agacatatgggctgaacacctttctctttttgcgttTATTGA CAaacacgtaagcctcCATTACGATTTTCATATCTTtttcaaaaaaatctgaaagaag g" /listShort="ybgG" /listLong="S93, ybgF" /label="upshifts" promotor_-35 complement(244242..244249) /Source="Nicolas_upshift_promotors" /id="U174" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig="0.999000999001" /xcortree=3068 /SigmaFactorBS="agacatatgggctgaacacctttctctttttgcgttTATTGA CAaacacgtaagcctcCATTACGATTTTCATATCTTtttcaaaaaaatctgaaagaag g" /listShort="ybgG" /listLong="S93, ybgF" /label="promotor_-35" CDS complement(244299..245735) /gene="glnT" /locus_tag="BSU_02420" /old_locus_tag="BSU02420" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15849754, 15995196, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glutamine transporter" /protein_id="NP_388124.2" /db_xref="EnsemblGenomes-Gn:BSU02420" /db_xref="EnsemblGenomes-Tr:CAB12036" /db_xref="GOA:O31464" /db_xref="InterPro:IPR001463" /db_xref="SubtiList:BG12752" /db_xref="UniProtKB/Swiss-Prot:O31464" /translation="MQQILEHIVGIANDLLWSKLLIVLLLSFGIYFTFRLKFLQVRML KEMVRVLREGAASRSKNSISPFQAFCISMAARVGTGNITGIAIAIALGGPGAIFWMWI IAIIGSASSFVESTLAQIYKVKDVNGFRGGPAYYMEKGLNKRWMGALFAVLITLSFGI VFNSVQSNTVSLAFENAFGTNRLTLGLILIAVFGTIIFGGVKRIAKLAESIVVVLAVL YIGVAFFVIFSNITQLPGVLALIVKNAFGFDQAAGGALGAALMQGVRRGIFSNEAGMG SAPNAAATATTSHPVKQGLIQAFGVLTDTLVICTSTAFIILFSDAYHTPGLSGIALTQ ASLSSHVGSWASGFLAILILLFGFCALIGNYYYGETNIGFLNKSKKLIFVYRIGVLAM IVFGCVAKVQLVWDLADLFMGLMVIVNLIAIFLLSKVVFTALKDYTRQKKAGKDPVFY KDVLKNHNGIECWPVSDTKTDTHNKQIS*" /label="glnT CDS" gene complement(244299..245735) /gene="glnT" /locus_tag="BSU_02420" /old_locus_tag="BSU02420" /label="glnT gene" downshifts complement(244314) /Source="Nicolas_upshifts" /id="D94" /incds=0 /nref=3 /ntot=3 /MaxReadThrough="0.598370000000001" /MaxDrop="4.3935" /score="-7.90227391" /energy="-11.4" /TU="NA" /idTUdmin="U174" /TUdmin="-1078" /isTUend="FALSE" /label="downshifts" CDS complement(245758..246741) /gene="glsA" /locus_tag="BSU_02430" /old_locus_tag="BSU02430" /EC_number="3.5.1.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15995196, 18459799, 20050917" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15995196, 18459799, 20050917; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutaminase" /protein_id="NP_388125.1" /db_xref="EnsemblGenomes-Gn:BSU02430" /db_xref="EnsemblGenomes-Tr:CAB12037" /db_xref="GOA:O31465" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR015868" /db_xref="PDB:1MKI" /db_xref="PDB:2OSU" /db_xref="PDB:3AGF" /db_xref="PDB:3BRM" /db_xref="SubtiList:BG12753" /db_xref="UniProtKB/Swiss-Prot:O31465" /translation="MKELIKEHQKDINPALQLHDWVEYYRPFAANGQSANYIPALGKV NDSQLGICVLEPDGTMIHAGDWNVSFTMQSISKVISFIAACMSRGIPYVLDRVDVEPT GDAFNSIIRLEINKPGKPFNPMINAGALTIASILPGESAYEKLEFLYSVMETLIGKRP RIHEEVFRSEWETAHRNRALAYYLKETNFLEAEVEETLEVYLKQCAMESTTEDIALIG LILAHDGYHPIRHEQVIPKDVAKLAKALMLTCGMYNASGKYAAFVGVPAKSGVSGGIM ALVPPSARREQPFQSGCGIGIYGPAIDEYGNSLTGGMLLKHMAQEWELSIF*" /label="glsA CDS" gene complement(245758..246741) /gene="glsA" /locus_tag="BSU_02430" /old_locus_tag="BSU02430" /label="glsA gene" promotor_-10 complement(246835..246852) /Source="Nicolas_upshift_promotors" /id="U175" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.71028971028971" /psig="0.97002997002997" /xcortree=1548 /SigmaFactorBS="tgcttattttcaaaatgtttttgtcgtATTTTGTAtgattct gtagtctcCATTATACAGTAATTATAccttccgctattatgaaagcgtttaacgcccc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature 246840..246859 /Source="Nicolas_upshift_promotors" /id="U176" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=1812 /SigmaFactorBS="tcaaaacgaaggctaagggggcgttaaacgctttcataatag cggaaggtataaTTACTGTATAATGGAGACTAcagaatcatacaaaatacgacaaaaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(246842) /Source="Nicolas_upshifts" /id="U175" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.71028971028971" /psig="0.97002997002997" /xcortree=1548 /SigmaFactorBS="tgcttattttcaaaatgtttttgtcgtATTTTGTAtgattct gtagtctcCATTATACAGTAATTATAccttccgctattatgaaagcgtttaacgcccc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts 246846 /Source="Nicolas_upshifts" /id="U176" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=1812 /SigmaFactorBS="tcaaaacgaaggctaagggggcgttaaacgctttcataatag cggaaggtataaTTACTGTATAATGGAGACTAcagaatcatacaaaatacgacaaaaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(246868..246875) /Source="Nicolas_upshift_promotors" /id="U175" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.71028971028971" /psig="0.97002997002997" /xcortree=1548 /SigmaFactorBS="tgcttattttcaaaatgtttttgtcgtATTTTGTAtgattct gtagtctcCATTATACAGTAATTATAccttccgctattatgaaagcgtttaacgcccc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 247043..248275 /gene="glnJ" /locus_tag="BSU_02440" /old_locus_tag="BSU02440" /EC_number="2.7.13.3" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 15995196, 17001076, 21435182, 23461034, 25691471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15995196, 17001076, 21435182, 23461034, 25691471; Product type rc : receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [GlnL] forglutamine degradation" /protein_id="NP_388126.2" /db_xref="EnsemblGenomes-Gn:BSU02440" /db_xref="EnsemblGenomes-Tr:CAB12038" /db_xref="GOA:P40758" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10871" /db_xref="UniProtKB/Swiss-Prot:P40758" /translation="MLITVPLAGELKFYPLNEEFRVSFGAPVFFFFLSLLRHVPAVLP GFLTGAAVFIFRVFLELWGGGHNGLTPILYDQASGFFFYMTYACLFSILKANRFRERP IMLGFIGFMIEVVSDCVELTVQFLIFHTVVTPEKITDIAVIAISHTFIVMSFYSVLKL YETQSREKQTRQQHEHMLMIVSNLYEETVHLKKTLKTTEKVTNDSYQLYREMKGKDVQ LSGRILRLAGEIHEVKKDNQRIFAGLSKLISNESLRDYMRASDLLQLVIRMNEKYAEA LGKQIDFYCSIEGEHDEYHVFIVLSIINNLTANAVEAMDEEGMVSLRLRKPNESMVEF QVEDNGPGISEKIGDIVFDPGFTSKYDEFGTPSTGIGLSYVKEIVTELEGDITFDNQQ RGVVFAIRLPVRHLIQKG*" /label="glnJ CDS" gene 247043..248275 /gene="glnJ" /locus_tag="BSU_02440" /old_locus_tag="BSU02440" /label="glnJ gene" CDS 248286..249230 /gene="glnL" /locus_tag="BSU_02450" /old_locus_tag="BSU02450" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 15995196" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15995196; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [GlnJ] for glutamine utilisation" /protein_id="NP_388127.1" /db_xref="EnsemblGenomes-Gn:BSU02450" /db_xref="EnsemblGenomes-Tr:CAB12039" /db_xref="GOA:P40759" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR013972" /db_xref="SubtiList:BG10872" /db_xref="UniProtKB/Swiss-Prot:P40759" /translation="MRFFIADDDRAVRSILRQIIEDEDLGEAAGEADDGSQVEGHMLQ FKQIDILLIDLLMPGRDGIETIRQIQNTYSGKIVMISQVEAKEMVGEAYSLGIEYFIH KPINRIEIVTVLQKVKERIELEHSIGAIQHSLSRLVNRTERKARPQQKSDSGLKEAGT FLLSELGMMGEGGAHDLMAVLQYLAEHEQSEPHEKQSPSLKQIFTQVAVRKLGTGASQ TEVNREMKASEQRIRRAIIHSLHHFASLGTTDFSNPKFETYASKFFDFPVVSQKMKEL QSKDAKPLAPARINMKKFIHVFFLEAKLLHETMKQRRI*" /label="glnL CDS" gene 248286..249230 /gene="glnL" /locus_tag="BSU_02450" /old_locus_tag="BSU02450" /label="glnL gene" downshifts 249207 /Source="Nicolas_upshifts" /id="D95" /incds=0 /nref=45 /ntot=191 /MaxReadThrough="1.43757" /MaxDrop="3.64091" /score="2.73020459" /energy="-6.2" /TU="NA" /idTUdmin="U177" /TUdmin="-484" /isTUend="FALSE" /label="downshifts" promotor_-35 249327..249334 /Source="Nicolas_upshift_promotors" /id="U177" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig="0.999000999001" /xcortree=370 /SigmaFactorBS="gccggacagtgatttaccgcttttttataaaatatcagaaaa taaagaTATTGACTtattgtttatttgTCTTACAATTAAACAAAAGGatatatgggaa g" /listShort="S94, ycbC" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 249339..249456 /Source="Nicolas_S_feature" /locus_tag="new_267772_267889" /HighExp="Sw, BC, M40t90, Etha, MG-0.2, HiTm, HiOs, G135, UNK1, MG-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S94" upshifts 249339 /Source="Nicolas_upshifts" /id="U177" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig="0.999000999001" /xcortree=370 /SigmaFactorBS="gccggacagtgatttaccgcttttttataaaatatcagaaaa taaagaTATTGACTtattgtttatttgTCTTACAATTAAACAAAAGGatatatgggaa g" /listShort="S94, ycbC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 249348..249367 /Source="Nicolas_upshift_promotors" /id="U177" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig="0.999000999001" /xcortree=370 /SigmaFactorBS="gccggacagtgatttaccgcttttttataaaatatcagaaaa taaagaTATTGACTtattgtttatttgTCTTACAATTAAACAAAAGGatatatgggaa g" /listShort="S94, ycbC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 249457..250383 /gene="kdgD" /locus_tag="BSU_02460" /old_locus_tag="BSU02460" /EC_number="4.2.1.41" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12044674; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="5-dehydro-4-deoxyglucarate dehydratase" /protein_id="NP_388128.2" /db_xref="EnsemblGenomes-Gn:BSU02460" /db_xref="EnsemblGenomes-Tr:CAB12040" /db_xref="GOA:P42235" /db_xref="InterPro:IPR002220" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR017655" /db_xref="SubtiList:BG11158" /db_xref="UniProtKB/Swiss-Prot:P42235" /translation="MSRIRKAPAGILGFPVAPFNTQGKLEEEALFQNIEFLLNEGLEA IFIACGSGEFQSLSQKEYEQMVEVAVSAAGGKVPVYTGVGGNLSTALDWAQLSEKKGA DGYLILPPYLVHGEQEGLYQYAKTIIESTDLNAILYQRDNAVLSVEQIKRLTECEQLV GVKDGVGNMDLNINLVYTIGDRLGWLNGMPMAEVTMPAYLPIGFHSYSSAISNYIPHI SRMFYDALKNGNDELVKELYRHVILPINDIRKQRKGYAVSLIKAGMEIMGLNVRNTAR PPVGPVEKDHYQQLEAILKQAADRFPKKAATV*" /label="kdgD CDS" gene 249457..250383 /gene="kdgD" /locus_tag="BSU_02460" /old_locus_tag="BSU02460" /label="kdgD gene" CDS 250413..251879 /gene="gucD" /locus_tag="BSU_02470" /old_locus_tag="BSU02470" /EC_number="1.2.1.26" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12044674, 17202142; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2,5-dioxovalerate dehydrogenase (alpha-ketoglutaric semialdehyde dehydrogenase)" /protein_id="NP_388129.1" /db_xref="EnsemblGenomes-Gn:BSU02470" /db_xref="EnsemblGenomes-Tr:CAB12041" /db_xref="GOA:P42236" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG11159" /db_xref="UniProtKB/Swiss-Prot:P42236" /translation="MSVITEQNTYLNFINGEWVKSQSGDMVKVENPADVNDIVGYVQN STAEDVERAVTAANEAKTAWRKLTGAERGQYLYKTADIMEQRLEEIAACATREMGKTL PEAKGETARGIAILRYYAGEGMRKTGDVIPSTDKDALMFTTRVPLGVVGVISPWNFPV AIPIWKMAPALVYGNTVVIKPATETAVTCAKIIACFEEAGLPAGVINLVTGPGSVVGQ GLAEHDGVNAVTFTGSNQVGKIIGQAALARGAKYQLEMGGKNPVIVADDADLEAAAEA VITGAFRSTGQKCTATSRVIVQSGIYERFKEKLLQRTKDITIGDSLKEDVWMGPIASK NQLDNCLSYIEKGKQEGASLLIGGEKLENGKYQNGYYVQPAIFDNVTSEMTIAQEEIF GPVIALIKVDSIEEALNIANDVKFGLSASIFTENIGRMLSFIDEIDAGLVRINAESAG VELQAPFGGMKQSSSHSREQGEAAKDFFTAIKTVFVKP*" /label="gucD CDS" gene 250413..251879 /gene="gucD" /locus_tag="BSU_02470" /old_locus_tag="BSU02470" /label="gucD gene" CDS 251963..253330 /gene="gudP" /locus_tag="BSU_02480" /old_locus_tag="BSU02480" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12044674, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12044674, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glucarate transporter" /protein_id="NP_388130.2" /db_xref="EnsemblGenomes-Gn:BSU02480" /db_xref="EnsemblGenomes-Tr:CAB12042" /db_xref="GOA:P42237" /db_xref="InterPro:IPR000849" /db_xref="InterPro:IPR004744" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11160" /db_xref="UniProtKB/Swiss-Prot:P42237" /translation="MKKDFASVTPAGKKTSVRWFIVFMLFLVTSINYADRATLSITGD SVQHDLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTIIALSIFFWSFFTLLQ GAIGFFSAGTAIILLFALRFLVGLSEAPSFPGNGRVVASWFPSSERGTASAFFNSAQY FAIVIFSPLMGWLTHSFGWHSVFVVMGIAGILLAVIWLKTVYEPKKHPKVNEAELAYI EQGGGLISMDDSKSKQETESKWPYIKQLLTNRMLIGVYIAQYCITTLTYFFLTWFPVY LVQARGMSILEAGFVASLPALCGFAGGVLGGIVSDILLKKGRSLTFARKVPIIAGMLL SCSMIVCNYTDSAWLVVVIMSLAFFGKGFGALGWAVVSDTSPKECAGLSGGLFNTFGN IASITTPIIIGYIVNATGSFNGALVFVGANAIAAILSYLLLVGPIKRVVLKKQEQDPD QSLPV*" /label="gudP CDS" gene 251963..253330 /gene="gudP" /locus_tag="BSU_02480" /old_locus_tag="BSU02480" /label="gudP gene" CDS 253367..254734 /gene="gudD" /locus_tag="BSU_02490" /old_locus_tag="BSU02490" /EC_number="4.2.1.40" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9772161, 12044674; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucarate dehydratase" /protein_id="NP_388131.2" /db_xref="EnsemblGenomes-Gn:BSU02490" /db_xref="EnsemblGenomes-Tr:CAB12043" /db_xref="GOA:P42238" /db_xref="InterPro:IPR013342" /db_xref="InterPro:IPR017653" /db_xref="InterPro:IPR029017" /db_xref="InterPro:IPR029065" /db_xref="InterPro:IPR034390" /db_xref="InterPro:IPR034598" /db_xref="InterPro:IPR036849" /db_xref="SubtiList:BG11161" /db_xref="UniProtKB/Swiss-Prot:P42238" /translation="MSSPIQEQVQKEKRSNIPSISEMKVIPVAGHDSMLLNLSGAHSP FFTRNIVILTDSSGNQGVGEVPGGEHIRRTLELSEPLVVGKSIGAYQAILQTVRKQFG DQDRGGRGNQTFDLRTTVHAVTALEAALLDLLGKFLQEPVAALLGEGKQRDEVKMLGY LFYIGDRNRTTLPYQSDEQSDCAWFRLRHEEALTPEAIVRLAESAQERYGFQDFKLKG GVLRGEEEIEAVTALSKRFPEARITLDPNGAWSLEEAIALCKGKQDVLAYAEDPCGDE NGYSAREVMAEFRRATGLPTATNMIATDWREMGHAIQLHAVDIPLADPHFWTMQGSVR VAQMCHDWGLTWGSHSNNHFDISLAMFTHVAAAAPGRITAIDTHWIWQDGQRLTKQPF EISSGCVKVPDKPGLGVDIDMEQVEKAHEIYRKMNLGARNDAIPMQFLISNWEFDRKR PCLVR*" /label="gudD CDS" gene 253367..254734 /gene="gudD" /locus_tag="BSU_02490" /old_locus_tag="BSU02490" /label="gudD gene" promotor_-35 254748..254755 /Source="Nicolas_upshift_promotors" /id="U178" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig="0.999000999001" /xcortree=2135 /SigmaFactorBS="gcgcccgtgtcttgtgcgataagtttgattgtaaaTATTGTC AtatccgctattttgTCTTACAATTGAACAACTgaagggagagttgttcgtgtacgaa g" /listShort="ycbG, garD" /listLong="S95, ycbJ, NA" /label="promotor_-35" promotor_-10 254770..254787 /Source="Nicolas_upshift_promotors" /id="U178" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig="0.999000999001" /xcortree=2135 /SigmaFactorBS="gcgcccgtgtcttgtgcgataagtttgattgtaaaTATTGTC AtatccgctattttgTCTTACAATTGAACAACTgaagggagagttgttcgtgtacgaa g" /listShort="ycbG, garD" /listLong="S95, ycbJ, NA" /label="promotor_-10" upshifts 254773 /Source="Nicolas_upshifts" /id="U178" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig="0.999000999001" /xcortree=2135 /SigmaFactorBS="gcgcccgtgtcttgtgcgataagtttgattgtaaaTATTGTC AtatccgctattttgTCTTACAATTGAACAACTgaagggagagttgttcgtgtacgaa g" /listShort="ycbG, garD" /listLong="S95, ycbJ, NA" /label="upshifts" CDS 254804..255505 /gene="garR" /locus_tag="BSU_02500" /old_locus_tag="BSU02500" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12044674" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12044674; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (GntR family)" /protein_id="NP_388132.2" /db_xref="EnsemblGenomes-Gn:BSU02500" /db_xref="EnsemblGenomes-Tr:CAB12044" /db_xref="GOA:P42239" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR008920" /db_xref="InterPro:IPR011711" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11162" /db_xref="UniProtKB/Swiss-Prot:P42239" /translation="MYEGLEDLKVDTVNRKTLAKQVIERIVHLLSSGQLRAGDKLPTE MELMDILHVSRPVLREALSSLETLGVITRKTRGGTYFNDKIGMQPFSVMLALATDNLP AIIEARMALELGLVTIAAEKINEEELQRLQKTIDDIANSTDNHYGEADKEFHRIIALS ANNPVVEGMIQSLLITHAKIDSQIPYRERDVTVEYHKKIYDALAKRDPYKAHYHMYEH LKFVRDKILKGMDEK*" /label="garR CDS" gene 254804..255505 /gene="garR" /locus_tag="BSU_02500" /old_locus_tag="BSU02500" /label="garR gene" downshifts 255455 /Source="Nicolas_upshifts" /id="D96" /incds=0 /nref=1 /ntot=35 /MaxReadThrough="3.59234" /MaxDrop="2.3923" /score="4.10541728" /energy="-9.5" /TU="U178" /idTUdmin="U178" /TUdmin="-1694" /isTUend="FALSE" /label="downshifts" downshifts 255499 /Source="Nicolas_upshifts" /id="D97" /incds=0 /nref=1 /ntot=82 /MaxReadThrough="3.21794" /MaxDrop="2.49226" /score="4.10541728" /energy="-9.5" /TU="U178" /idTUdmin="U178" /TUdmin="-1650" /isTUend="FALSE" /label="downshifts" CDS 255596..257128 /gene="garD" /locus_tag="BSU_02510" /old_locus_tag="BSU02510" /EC_number="4.2.1.42" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9772162; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="D-galactarate dehydratase" /protein_id="NP_388133.2" /db_xref="EnsemblGenomes-Gn:BSU02510" /db_xref="EnsemblGenomes-Tr:CAB12045" /db_xref="GOA:P42240" /db_xref="InterPro:IPR007392" /db_xref="InterPro:IPR013974" /db_xref="InterPro:IPR017654" /db_xref="SubtiList:BG11163" /db_xref="UniProtKB/Swiss-Prot:P42240" /translation="MAMNLRKNQAPLYIKVHEIDNTAIIVNDGGLPKGTVFSCGLVLE EDVPQGHKVALTDLNQGDEIVRYGEVIGFADETIKRGSWIREALVRMPAPPALDDLPL ANRVPQPRPPLEGYTFEGYRNADGSAGTKNILGITTSVQCVVGVLDYAVKRIKEELLP KYPNVDDVVPLHHQYGCGVAINAPDAVIPIRTIQNLAKHPNFGGEVMVIGLGCEKLLP ERIASENDDDILSLQDHRGFAAMIQSILEMAEERLIRLNSRTRVSCPVSDLVIGLQCG GSDAFSGVTANPAVGYAADLLVRAGATVLFSEVTEVRDAIHLLTPRAVSEEVGQSLIK EMKWYDSYLRRGDADRSANPSPGNKKGGLSNVVEKALGSVAKSGTSPISGVLGPGERA KQKGLLFAATPASDFVCGTLQLAAGMNLQVFTTGRGTPYGLAAAPVLKVSTRHSLSEH WADLIDINAGRIATGEASIEDVGWEIFRTILDVASGRKQTWADRWGLHNDLCLFNPAP VT*" /label="garD CDS" gene 255596..257128 /gene="garD" /locus_tag="BSU_02510" /old_locus_tag="BSU02510" /label="garD gene" promotor_-35 257140..257143 /Source="Nicolas_upshift_promotors" /id="U179" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=422 /SigmaFactorBS="tcctgctccagtgacttgattcatgtttttATAGcggaaaga tggaatATGCTGTAAAATGAAAATCAgcgtataggaaacggaggggttacagcatggc a" /listShort="S95, ycbJ, NA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 257158..257177 /Source="Nicolas_upshift_promotors" /id="U179" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=422 /SigmaFactorBS="tcctgctccagtgacttgattcatgtttttATAGcggaaaga tggaatATGCTGTAAAATGAAAATCAgcgtataggaaacggaggggttacagcatggc a" /listShort="S95, ycbJ, NA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 257170..257404 /Source="Nicolas_S_feature" /locus_tag="new_275603_275837" /HighExp="LoTm, Sw, BC, BI, B60, B36, T3.30H, T5.0H, T4.0H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.50265400000000005" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.999" /label="S95" upshifts 257170 /Source="Nicolas_upshifts" /id="U179" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=422 /SigmaFactorBS="tcctgctccagtgacttgattcatgtttttATAGcggaaaga tggaatATGCTGTAAAATGAAAATCAgcgtataggaaacggaggggttacagcatggc a" /listShort="S95, ycbJ, NA" /GFF_Attribute="listLong" /label="upshifts" CDS 257405..258325 /gene="ycbJ" /locus_tag="BSU_02520" /old_locus_tag="BSU02520" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12044674; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphotransferase" /protein_id="NP_388134.1" /db_xref="EnsemblGenomes-Gn:BSU02520" /db_xref="EnsemblGenomes-Tr:CAB12046" /db_xref="GOA:P42242" /db_xref="InterPro:IPR002575" /db_xref="InterPro:IPR011009" /db_xref="SubtiList:BG11165" /db_xref="UniProtKB/Swiss-Prot:P42242" /translation="MTNLNEKQLITEIVGLARSQGLTVHSENAQLNETGMDFQVVFAK DDTGMPWVLRKPRRSDVVERASAEGITLAFLRANLTADVPDWRIHTPELIAYPMLKGT PAAGIDLEQKQYVWNMDHQPPSDDFVRTLADILAELHGTDQISAGQSGIEVIRPEDFR QMTADSMVDVKNKLGVSTTLWERWQKWVDDDAYWPGFSSLIHGDLHPPHILIDQNGRV TGLLDWTEAKVADPAKDFVLYQTIFGEKETARLLEYYDQAGGRIWAKMQEHISEMQAA YPVEIAKLALQTQQEEHINMALEALGVTSD*" /label="ycbJ CDS" gene 257405..258325 /gene="ycbJ" /locus_tag="BSU_02520" /old_locus_tag="BSU02520" /label="ycbJ gene" promotor_-35 258327..258334 /Source="Nicolas_upshift_promotors" /id="U180" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.869130869130869" /psig=1 /xcortree=572 /SigmaFactorBS="gaagcacttggtgtaacatcggattaagAATTGACTtcgttt catgaaccGAGTATTATAAACTCTACAAataatagaacggattaacaatcgtgaggaa g" /listShort="NA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 258349..258368 /Source="Nicolas_upshift_promotors" /id="U180" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.869130869130869" /psig=1 /xcortree=572 /SigmaFactorBS="gaagcacttggtgtaacatcggattaagAATTGACTtcgttt catgaaccGAGTATTATAAACTCTACAAataatagaacggattaacaatcgtgaggaa g" /listShort="NA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 258359 /Source="Nicolas_upshifts" /id="U180" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.869130869130869" /psig=1 /xcortree=572 /SigmaFactorBS="gaagcacttggtgtaacatcggattaagAATTGACTtcgttt catgaaccGAGTATTATAAACTCTACAAataatagaacggattaacaatcgtgaggaa g" /listShort="NA" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 258382..258629 /gene="tboW" /locus_tag="BSU_misc_RNA_6" /product="T-box riboswitch specific of tryptophan tRNA ligase" /experiment="publication(s) with functional evidences, PMID:1317842, 9098041, 10706627, 12165569, 12547201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1317842, 9098041, 10706627, 12165569, 12547201; Product type n: RNA" /label="tboW RNA" gene 258382..258629 /gene="tboW" /locus_tag="BSU_misc_RNA_6" /label="tboW gene" downshifts 258598 /Source="Nicolas_upshifts" /id="D98" /incds=0 /nref=225 /ntot=264 /MaxReadThrough="2.36361" /MaxDrop="6.52913" /score="36.5571172" /energy="-16.6" /TU="NA" /idTUdmin="U179" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS 258727..258888 /gene="rtpA" /locus_tag="BSU_02530" /old_locus_tag="BSU02530" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10706627, 11557884, 12855807, 15099736, 15213402, 15743934, 16306262" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10706627, 11557884, 12855807, 15099736, 15213402, 15743934, 16306262; Product type r: regulator" /codon_start=1 /transl_table=11 /product="anti-TRAP regulator" /protein_id="NP_388135.1" /db_xref="EnsemblGenomes-Gn:BSU02530" /db_xref="EnsemblGenomes-Tr:CAB12047" /db_xref="GOA:O31466" /db_xref="InterPro:IPR031538" /db_xref="InterPro:IPR036410" /db_xref="PDB:2BX9" /db_xref="PDB:2KO8" /db_xref="PDB:2ZP8" /db_xref="PDB:2ZP9" /db_xref="SubtiList:BG12776" /db_xref="UniProtKB/Swiss-Prot:O31466" /translation="MVIATDDLEVACPKCERAGEIEGTPCPACSGKGVILTAQGYTLL DFIQKHLNK*" /label="rtpA CDS" gene 258727..258888 /gene="rtpA" /locus_tag="BSU_02530" /old_locus_tag="BSU02530" /label="rtpA gene" promotor_no_box 258805..258905 /Source="Nicolas_upshift_promotors" /id="U181" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.544455544455544" /psig="0.010989010989011" /xcortree=1479 /SigmaFactorBS="ccggcctgcagcggaaaaggtgttattctgactgctcaagga tatacgcttctcgattttatccaaaagcatttgaataagtaaaggagaaaagctgagc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 258865 /Source="Nicolas_upshifts" /id="U181" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.544455544455544" /psig="0.010989010989011" /xcortree=1479 /SigmaFactorBS="ccggcctgcagcggaaaaggtgttattctgactgctcaagga tatacgcttctcgattttatccaaaagcatttgaataagtaaaggagaaaagctgagc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 258909..259847 /gene="ycbK" /locus_tag="BSU_02540" /old_locus_tag="BSU02540" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10706627, 15063849, 15849754, 16850406, 16879415, 17114263; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative tryptophan or indole exporter" /protein_id="NP_388136.1" /db_xref="EnsemblGenomes-Gn:BSU02540" /db_xref="EnsemblGenomes-Tr:CAB12048" /db_xref="GOA:P42243" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG11166" /db_xref="UniProtKB/Swiss-Prot:P42243" /translation="MRAEEQSKIREAAAGTIFLLIGTVCFASKSIWIKWAYQMGAEPD AVLLYRQLLAVPLFWLIFLIYRPPMPDGKKKGDLWKACGAGVFCFFLSPLLDFIGLNH VSAMVERILLMSYPLFVFGFTACRDRKMSSIQDLFAVLAVMFGLFLALGGWNAELFQA NMIGAVFILLSSAVYAGYLVLSGHLVHQIGGIRLNAYGMTAAGAAMMLYTGIKSAAGM NTPMAAYPLSMYGLFAVIAVVTTVIPFVLMLEGIKRIGAQRAAAISMAGPILTIFYGA LFLGERLGLIQVIGCGGVFFVITGMEYRKLKTGKKE*" /label="ycbK CDS" gene 258909..259847 /gene="ycbK" /locus_tag="BSU_02540" /old_locus_tag="BSU02540" /label="ycbK gene" downshifts 258953 /Source="Nicolas_upshifts" /id="D99" /incds=0 /nref=1 /ntot=7 /MaxReadThrough="3.05417" /MaxDrop="3.72787" /score="0.773303272" /energy="-9" /TU="NA" /idTUdmin="U181" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature 259870..259889 /Source="Nicolas_upshift_promotors" /id="U182" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.699300699300699" /psig="0.998001998001998" /xcortree=2265 /SigmaFactorBS="tacaggaagctgaaaacaggaaaaaaagaataatttttataa aacacacacgtttTTCAATTACAATAAGTGTAAttacgtgtgtgttttttgattttgt a" /listShort="S96, ycbL, ycbM" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 259875..259943 /Source="Nicolas_S_feature" /locus_tag="new_278308_278376" /HighExp="C90, dia5, Lbtran, Lbexp, LBGexp, SMM, dia0, dia15, BMM, T-3.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S96" upshifts 259875 /Source="Nicolas_upshifts" /id="U182" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.699300699300699" /psig="0.998001998001998" /xcortree=2265 /SigmaFactorBS="tacaggaagctgaaaacaggaaaaaaagaataatttttataa aacacacacgtttTTCAATTACAATAAGTGTAAttacgtgtgtgttttttgattttgt a" /listShort="S96, ycbL, ycbM" /GFF_Attribute="listLong" /label="upshifts" CDS 259944..260624 /gene="ycbL" /locus_tag="BSU_02550" /old_locus_tag="BSU02550" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YcbM]" /protein_id="NP_388137.2" /db_xref="EnsemblGenomes-Gn:BSU02550" /db_xref="EnsemblGenomes-Tr:CAB12049" /db_xref="GOA:P42244" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11167" /db_xref="UniProtKB/Swiss-Prot:P42244" /translation="MLVEDDHSISEMVDHYLTKEGFGIVHAFDGEEGIRLFQQGSYDL VLLDIMLPKLNGMDFLKIIREKSNIPVLMISAKDGDVDKALGLGFGADDYIAKPFSMI ELTARVKAAIRRATQYSAEEPAVNKVIRIHQLAIDIDNVSVLKNGEPLQLTSTEWQLL CLFASNPKKVFTKEQIYRSVWNEEYFDDQNIINVHMRRLREKIEDDPSSPQYIKTLWG IGYKLGEF*" /label="ycbL CDS" gene 259944..260624 /gene="ycbL" /locus_tag="BSU_02550" /old_locus_tag="BSU02550" /label="ycbL gene" CDS 260626..261561 /gene="ycbM" /locus_tag="BSU_02560" /old_locus_tag="BSU02560" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YcbL]" /protein_id="NP_388138.2" /db_xref="EnsemblGenomes-Gn:BSU02560" /db_xref="EnsemblGenomes-Tr:CAB12050" /db_xref="GOA:P42245" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11168" /db_xref="UniProtKB/Swiss-Prot:P42245" /translation="MTVLWVAAVIALACLNVIQFIMKKKRDGNLAYTADQLSYMLSRD SAGQILLPTDDHALKDLLVNINLIVENRQQISAQFAKTEQSMKRMLTNMSHDLKTPLT VILGYIEAIQSDPNMPDEERERLLGKLRQKTNELIQMINSFFDLAKLESEDKEIPITK VHMNDICKRNILHYYDAVQSKGFQAAIDIPDTPVYAQANEEALDRILQNLLSNAIQYG AAGKLIGLTLSYDERNIAITVWDRGKGISETDQQRVFERLYTLEESRNKAFQGSGLGL TITKRLTEKMGGIISVQSKPYERTAFTITLKRMTY*" /label="ycbM CDS" gene 260626..261561 /gene="ycbM" /locus_tag="BSU_02560" /old_locus_tag="BSU02560" /label="ycbM gene" CDS 261653..262576 /gene="ycbN" /locus_tag="BSU_02570" /old_locus_tag="BSU02570" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12486040; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC efflux transporter (ATP-binding protein)" /protein_id="NP_388139.2" /db_xref="EnsemblGenomes-Gn:BSU02570" /db_xref="EnsemblGenomes-Tr:CAB12051" /db_xref="GOA:P42246" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11169" /db_xref="UniProtKB/Swiss-Prot:P42246" /translation="MTYIVQTNGLTKTYQGKEVVSNVSMHIKKGEIYGFLGPNGAGKT TIMKMLTSLVKPTSGEIIILGNKFTHTSYEVLGNIGSMIEYPIFYENLTAEENLDLHC EYMGYHNKKAIQEVLDMVNLKQIDKKPVKTFSLGMKQRLGIARAILTKPDLLILDEPV NGLDPLGIKKIRQLFQVLSKEYGMTLLISSHLLGEIEQIADTIGVIRDGRLLEEVSME DVRGQNTEYIELVTPNQTRACFVLEKELQLTNFKILNEKTIRIYEAEASQAAISKALI LNDVDIESMNKKYTSLEDYFIKLINGNSISA*" /label="ycbN CDS" gene 261653..262576 /gene="ycbN" /locus_tag="BSU_02570" /old_locus_tag="BSU02570" /label="ycbN gene" S_feature complement(262123..263307) /Source="Nicolas_S_feature" /locus_tag="new_280556_281740_c" /HighExp="Etha, Sw, Gly, B36, LoTm, B60, GM 150, Salt, C30, ferm" /AntisenseName="ycbO" /AntisenseCor="-0.38911425676406203" /AntisenseRegPval="-10.4" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S97" CDS 262595..263281 /gene="ycbO" /locus_tag="BSU_02580" /old_locus_tag="BSU02580" /function="16.1: Circulate" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na+-driven exporter" /protein_id="NP_388140.3" /db_xref="EnsemblGenomes-Gn:BSU02580" /db_xref="EnsemblGenomes-Tr:CAB12052" /db_xref="GOA:P42247" /db_xref="InterPro:IPR032688" /db_xref="SubtiList:BG11170" /db_xref="UniProtKB/Swiss-Prot:P42247" /translation="MNLIRIELRKMKMGWYIRGALIANVIIMGFMWLISYSEKADGGV SFQSTDEAFLIIGTFVRAVFIVFGAVLIVKLVISEYKNKTILVMFTYPISRKKLLTAK LMIAGGLTFITILLSNILIAAGFFWLNSICHFIPGELTSEIISQQAVKMAVFAFGAAG TSLVPIFFGMRRHSVPATIISSVVIVMLISSTSPGFSISSVVYIPLSLAAFGLFFSYM AIRNADKQDA*" /label="ycbO CDS" gene 262595..263281 /gene="ycbO" /locus_tag="BSU_02580" /old_locus_tag="BSU02580" /label="ycbO gene" CDS complement(263242..263376) /locus_tag="BSU_02585" /old_locus_tag="BSU02585" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513940.1" /translation="MARSIILKQEQTHNGKAGADSIGLLYILGAFVYASCLSAFLIAM *" /label="hypothetical protein CDS" gene complement(263242..263376) /locus_tag="BSU_02585" /old_locus_tag="BSU02585" /label="gene" downshifts 263276 /Source="Nicolas_upshifts" /id="D100" /incds=0 /nref=8 /ntot=120 /MaxReadThrough="1.13131" /MaxDrop="3.44039" /score="18.1873505" /energy="-11.4" /TU="NA" /idTUdmin="U184" /TUdmin="-1166" /isTUend="FALSE" /label="downshifts" CDS complement(263336..263722) /gene="ycbP" /locus_tag="BSU_02590" /old_locus_tag="BSU02590" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22582280; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative inner integral membrane protein" /protein_id="NP_388141.1" /db_xref="EnsemblGenomes-Gn:BSU02590" /db_xref="EnsemblGenomes-Tr:CAB12053" /db_xref="GOA:P42248" /db_xref="InterPro:IPR019649" /db_xref="SubtiList:BG11171" /db_xref="UniProtKB/Swiss-Prot:P42248" /translation="MTHVKALAIKGIMTIIVLYLVLGLGFGFTFGDTLLMTIVLGVIS YLLGDLYVLPKWNNMIATLADFGLAFLVIWLMGMPLSMGMTGGEVALAALFGAIVMAI GEYCFHFYMMSKEIGKKHYLETRTDS*" /label="ycbP CDS" gene complement(263336..263722) /gene="ycbP" /locus_tag="BSU_02590" /old_locus_tag="BSU02590" /label="ycbP gene" downshifts complement(263352) /Source="Nicolas_upshifts" /id="D101" /incds=0 /nref=148 /ntot=217 /MaxReadThrough="6.64196" /MaxDrop="7.40353" /score="13.8182557" /energy="-15.6" /TU="U183" /idTUdmin="U185" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(263748..263766) /Source="Nicolas_upshift_promotors" /id="U183" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=164 /SigmaFactorBS="ctctccccagcagatttgcacccgcctccgaaaagaaataaG GTTTAActttttacatttgAGGAATTATACATAACAAAtcaaatgacaaaaggaggaa t" /listShort="ycbP, S97" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(263767) /Source="Nicolas_upshifts" /id="U183" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=164 /SigmaFactorBS="ctctccccagcagatttgcacccgcctccgaaaagaaataaG GTTTAActttttacatttgAGGAATTATACATAACAAAtcaaatgacaaaaggaggaa t" /listShort="ycbP, S97" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(263780..263786) /Source="Nicolas_upshift_promotors" /id="U183" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=164 /SigmaFactorBS="ctctccccagcagatttgcacccgcctccgaaaagaaataaG GTTTAActttttacatttgAGGAATTATACATAACAAAtcaaatgacaaaaggaggaa t" /listShort="ycbP, S97" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(263800..264798) /Source="Nicolas_S_feature" /locus_tag="new_282233_283231_c" /HighExp="GM 150, T0.30H, C30, T1.30H, T1.0H, T-0.40H, T-3.40H, T2.0H, T2.30H, T-4.40H" /AntisenseName="cwlJ" /AntisenseCor="0.11463160303596701" /AntisenseRegPval="-1.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.975" /TUlongSig="NA" /TUlongPSig="NA" /label="S98" downshifts complement(263843) /Source="Nicolas_upshifts" /id="D102" /incds=0 /nref=3 /ntot=10 /MaxReadThrough="5.23914" /MaxDrop="3.14515" /score="13.8182557" /energy="-15.6" /TU="U185,U187" /idTUdmin="U185" /TUdmin="-491" /isTUend="FALSE" /label="downshifts" promotor_-35 263979..263984 /Source="Nicolas_upshift_promotors" /id="U184" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1108 /SigmaFactorBS="gtttttagatgaataaatttaaaaacttctcctgtccctccG TCATCacttctgaagtaatgAAATATGATGAAAAGAGATcaaggggaggtgacgtgat g" /listShort="cwlJ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 263998 /Source="Nicolas_upshifts" /id="U184" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1108 /SigmaFactorBS="gtttttagatgaataaatttaaaaacttctcctgtccctccG TCATCacttctgaagtaatgAAATATGATGAAAAGAGATcaaggggaggtgacgtgat g" /listShort="cwlJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 264000..264018 /Source="Nicolas_upshift_promotors" /id="U184" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1108 /SigmaFactorBS="gtttttagatgaataaatttaaaaacttctcctgtccctccG TCATCacttctgaagtaatgAAATATGATGAAAAGAGATcaaggggaggtgacgtgat g" /listShort="cwlJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(264012) /Source="Nicolas_upshifts" /id="U185" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=680 /SigmaFactorBS="aatcgacatccgcactcgttgctctcacgaccGCCATcacgt caCCTCCCCTTGATCTCttttcatcatatttcattacttcagaagtgatgacggaggg a" /listShort="ycbP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(264014..264028) /Source="Nicolas_upshift_promotors" /id="U185" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=680 /SigmaFactorBS="aatcgacatccgcactcgttgctctcacgaccGCCATcacgt caCCTCCCCTTGATCTCttttcatcatatttcattacttcagaagtgatgacggaggg a" /listShort="ycbP" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(264034) /Source="Nicolas_upshifts" /id="D103" /incds=0 /nref=2 /ntot=5 /MaxReadThrough="5.64474" /MaxDrop="3.76775" /score="13.8182557" /energy="-15.6" /TU="U187" /idTUdmin="U185" /TUdmin="-682" /isTUend="FALSE" /label="downshifts" promotor_-35 complement(264036..264040) /Source="Nicolas_upshift_promotors" /id="U185" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=680 /SigmaFactorBS="aatcgacatccgcactcgttgctctcacgaccGCCATcacgt caCCTCCCCTTGATCTCttttcatcatatttcattacttcagaagtgatgacggaggg a" /listShort="ycbP" /GFF_Attribute="listLong" /label="promotor_-35" CDS 264036..264464 /gene="cwlJ" /locus_tag="BSU_02600" /old_locus_tag="BSU02600" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9515903, 11466292, 11807087, 12177332, 16936016, 26190134, 28333204" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9515903, 11466292, 11807087, 12177332, 16936016, 26190134, 28333204; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore cortex cell wall hydrolase" /protein_id="NP_388142.2" /db_xref="EnsemblGenomes-Gn:BSU02600" /db_xref="EnsemblGenomes-Tr:CAB12054" /db_xref="GOA:P42249" /db_xref="InterPro:IPR011105" /db_xref="SubtiList:BG11172" /db_xref="UniProtKB/Swiss-Prot:P42249" /translation="MAVVRATSADVDLMARLLRAEAEGEGKQGMLLVGNVGINRLRAN CSDFKGLRTIRQMIYQPHAFEAVTHGYFYQRARDSERALARRSINGERRWPAKFSLWY FRPQGDCPAQWYNQPFVARFKSHCFYQPTAETCENVYNTF*" /label="cwlJ CDS" gene 264036..264464 /gene="cwlJ" /locus_tag="BSU_02600" /old_locus_tag="BSU02600" /label="cwlJ gene" downshifts 264443 /Source="Nicolas_upshifts" /id="D104" /incds=0 /nref=44 /ntot=63 /MaxReadThrough="2.30044" /MaxDrop="5.89045" /score="18.1873505" /energy="-11.4" /TU="NA" /idTUdmin="U184" /TUdmin=1 /isTUend="TRUE" /label="downshifts" promotor_-35 264509..264515 /Source="Nicolas_upshift_promotors" /id="U186" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.535464535464535" /psig="0.973026973026973" /xcortree=1784 /SigmaFactorBS="ggacaccgttcaaattgaacggtgtttttctttgaaaagATG CAATgcaaaatattccTGTGAGATAATCAAAGAAAAaagagctgacggagatgacaga a" /listShort="ycbR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 264528..264547 /Source="Nicolas_upshift_promotors" /id="U186" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.535464535464535" /psig="0.973026973026973" /xcortree=1784 /SigmaFactorBS="ggacaccgttcaaattgaacggtgtttttctttgaaaagATG CAATgcaaaatattccTGTGAGATAATCAAAGAAAAaagagctgacggagatgacaga a" /listShort="ycbR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 264530 /Source="Nicolas_upshifts" /id="U186" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.535464535464535" /psig="0.973026973026973" /xcortree=1784 /SigmaFactorBS="ggacaccgttcaaattgaacggtgtttttctttgaaaagATG CAATgcaaaatattccTGTGAGATAATCAAAGAAAAaagagctgacggagatgacaga a" /listShort="ycbR" /GFF_Attribute="listLong" /label="upshifts" CDS 264570..265301 /gene="ycbR" /locus_tag="BSU_02610" /old_locus_tag="BSU02610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388143.2" /db_xref="EnsemblGenomes-Gn:BSU02610" /db_xref="EnsemblGenomes-Tr:CAB12055" /db_xref="InterPro:IPR002035" /db_xref="InterPro:IPR019303" /db_xref="InterPro:IPR036465" /db_xref="SubtiList:BG11173" /db_xref="UniProtKB/Swiss-Prot:P42250" /translation="MATIDLQKKSVKIVLEKKQLTKVTARVGLVLDITGSMRPLYKNG TVQNVVERILAVADQFDDNGLLDVWVYDNEFSRLKPVSEKDFSGYVDREILNNDRLHK FGRNDEPPVMKDVLRKYVTEEPSSYPAFIVFINDGGCKKSIKPIIEASSDKPVFWQFV GIGNGNFDFLNKLDTLEGRVIDNTNFLHIEEIDRISDDELYDALLAEFPFWLKEAKEK GIVREQEPPAEKPKKKGFFSRLFSK*" /label="ycbR CDS" gene 264570..265301 /gene="ycbR" /locus_tag="BSU_02610" /old_locus_tag="BSU02610" /label="ycbR gene" promotor_-10 complement(264772..264791) /Source="Nicolas_upshift_promotors" /id="U187" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.932067932067932" /psig="0.975024975024975" /xcortree=2967 /SigmaFactorBS="tatttaaaatttcacgatcgacatagcccgaaaaatcctttt ctgaAACTGGCTttaatcgggaaaaTTCATTATCATACACCCATAcatccagcaaacc g" /listShort="S98, ycbP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(264798) /Source="Nicolas_upshifts" /id="U187" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.932067932067932" /psig="0.975024975024975" /xcortree=2967 /SigmaFactorBS="tatttaaaatttcacgatcgacatagcccgaaaaatcctttt ctgaAACTGGCTttaatcgggaaaaTTCATTATCATACACCCATAcatccagcaaacc g" /listShort="S98, ycbP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(264805..264812) /Source="Nicolas_upshift_promotors" /id="U187" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.932067932067932" /psig="0.975024975024975" /xcortree=2967 /SigmaFactorBS="tatttaaaatttcacgatcgacatagcccgaaaaatcctttt ctgaAACTGGCTttaatcgggaaaaTTCATTATCATACACCCATAcatccagcaaacc g" /listShort="S98, ycbP" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 265219 /Source="Nicolas_upshifts" /id="D105" /incds=1 /nref=9 /ntot=148 /MaxReadThrough="1.70712" /MaxDrop="3.61288" /score="25.6672471" /energy="-14.1" /TU="NA" /idTUdmin="U186" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS 265383..265559 /gene="yczK" /locus_tag="BSU_02619" /old_locus_tag="BSU02619" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097673.1" /db_xref="EnsemblGenomes-Gn:BSU02619" /db_xref="EnsemblGenomes-Tr:CAX52543" /db_xref="UniProtKB/Swiss-Prot:C0H3T2" /translation="MGGLQTTGYAENASFSQLSACFSSRLVREDLFLMFSAYNQFTLL HSRLTMISYNGDDQ*" /label="yczK CDS" gene 265383..265559 /gene="yczK" /locus_tag="BSU_02619" /old_locus_tag="BSU02619" /label="yczK gene" promotor_-35 265511..265517 /Source="Nicolas_upshift_promotors" /id="U188" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.942057942057942" /psig="0.056943056943057" /xcortree=6 /SigmaFactorBS="gtttttaatgttcagcgcttacaatcagttcacactTCTTCA CagtcgtTTAACAATGATTTCCTATaatggagacgatcaatgaggagagaggggatct t" /listShort="phoD, tatAD, S99, tatCD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 265524..265541 /Source="Nicolas_upshift_promotors" /id="U188" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.942057942057942" /psig="0.056943056943057" /xcortree=6 /SigmaFactorBS="gtttttaatgttcagcgcttacaatcagttcacactTCTTCA CagtcgtTTAACAATGATTTCCTATaatggagacgatcaatgaggagagaggggatct t" /listShort="phoD, tatAD, S99, tatCD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 265535 /Source="Nicolas_upshifts" /id="U188" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.942057942057942" /psig="0.056943056943057" /xcortree=6 /SigmaFactorBS="gtttttaatgttcagcgcttacaatcagttcacactTCTTCA CagtcgtTTAACAATGATTTCCTATaatggagacgatcaatgaggagagaggggatct t" /listShort="phoD, tatAD, S99, tatCD" /GFF_Attribute="listLong" /label="upshifts" CDS 265578..267329 /gene="phoD" /locus_tag="BSU_02620" /old_locus_tag="BSU02620" /EC_number="3.1.4.46" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11719524, 12867413, 16698798, 19395490, 19616508, 21479178, 27780866" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11719524, 12867413, 16698798, 19395490, 19616508, 21479178, 27780866; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="secreted phosphodiesterase (endo-hydrolysis at non-specific sites throughout the cell wall teichoic acid polymer)" /protein_id="NP_388144.2" /db_xref="EnsemblGenomes-Gn:BSU02620" /db_xref="EnsemblGenomes-Tr:CAB12056" /db_xref="GOA:P42251" /db_xref="InterPro:IPR008963" /db_xref="InterPro:IPR018946" /db_xref="InterPro:IPR029052" /db_xref="InterPro:IPR032093" /db_xref="PDB:2YEQ" /db_xref="SubtiList:BG11174" /db_xref="UniProtKB/Swiss-Prot:P42251" /translation="MAYDSRFDEWVQKLKEESFQNNTFDRRKFIQGAGKIAGLSLGLT IAQSVGAFEVNAAPNFSSYPFTLGVASGDPLSDSVVLWTRLAPDPLNGGGMPKQAVPV KWEVAKDEHFRKIVRKGTEMAKPSLAHSVHVEADGLEPNKVYYYRFKTGHELSPVGKT KTLPAPGANVPQMTFAFASCQQYEHGYYTAYKHMAKEKLDLVFHLGDYIYEYGPNEYV SKTGNVRTHNSAEIITLQDYRNRHAQYRSDANLKAAHAAFPWVVTWDDHEVENNYANK IPEKGQSVEAFVLRRAAAYQAYYEHMPLRISSLPNGPDMQLYRHFTYGNLASFNVLDT RQYRDDQANNDGNKPPSDESRNPNRTLLGKEQEQWLFNNLGSSTAHWNVLAQQIFFAK WNFGTSASPIYSMDSWDGYPAQRERVINFIKSKNLNNVVVLTGDVHASWASNLHVDFE KTSSKIFGAEFVGTSITSGGNGADKRADTDQILKENPHIQFFNDYRGYVRCTVTPHQW KADYRVMPFVTEPGAAISTRASFVYQKDQTGLRKVSSTTIQGGVKQSDEVEEDRFFSH NKAHEKQMIKKRAKITN*" /label="phoD CDS" gene 265578..267329 /gene="phoD" /locus_tag="BSU_02620" /old_locus_tag="BSU02620" /label="phoD gene" promotor_-10 complement(265632..265647) /Source="Nicolas_upshift_promotors" /id="U189" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.875124875124875" /psig="0.875124875124875" /xcortree=1703 /SigmaFactorBS="gagaaagtcctgcaatcttccccgctcctTGAATAAATTtgc ggcggtcaaACGTATTGTTTTGAAAgctttcctctttcagtttctgtacccattcatc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(265638) /Source="Nicolas_upshifts" /id="U189" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.875124875124875" /psig="0.875124875124875" /xcortree=1703 /SigmaFactorBS="gagaaagtcctgcaatcttccccgctcctTGAATAAATTtgc ggcggtcaaACGTATTGTTTTGAAAgctttcctctttcagtttctgtacccattcatc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(265660..265669) /Source="Nicolas_upshift_promotors" /id="U189" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.875124875124875" /psig="0.875124875124875" /xcortree=1703 /SigmaFactorBS="gagaaagtcctgcaatcttccccgctcctTGAATAAATTtgc ggcggtcaaACGTATTGTTTTGAAAgctttcctctttcagtttctgtacccattcatc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 267342..267554 /gene="tatAD" /locus_tag="BSU_02630" /old_locus_tag="BSU02630" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12867413, 15554971, 16678787, 19049517, 21479530, 27984091" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12867413, 15554971, 16678787, 19049517, 21479530, 27984091; Product type t : transporter" /codon_start=1 /transl_table=11 /product="component of the twin-arginine pre-protein translocation pathway" /protein_id="NP_388145.2" /db_xref="EnsemblGenomes-Gn:BSU02630" /db_xref="EnsemblGenomes-Tr:CAB12057" /db_xref="GOA:O31467" /db_xref="InterPro:IPR003369" /db_xref="InterPro:IPR003998" /db_xref="InterPro:IPR006312" /db_xref="PDB:2L16" /db_xref="SubtiList:BG12777" /db_xref="UniProtKB/Swiss-Prot:O31467" /translation="MFSNIGIPGLILIFVIALIIFGPSKLPEIGRAAGRTLLEFKSAT KSLVSGDEKEEKSAELTAVKQDKNAG*" /label="tatAD CDS" gene 267342..267554 /gene="tatAD" /locus_tag="BSU_02630" /old_locus_tag="BSU02630" /label="tatAD gene" S_feature 267555..267614 /Source="Nicolas_S_feature" /locus_tag="new_285988_286047" /HighExp="LPhT, BI, Paraq, C90, H2O2, M40t90, C30, M0t90, GM 60, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.0569" /TUlongSig="NA" /TUlongPSig="NA" /label="S99" CDS 267615..268343 /gene="tatCD" /locus_tag="BSU_02640" /old_locus_tag="BSU02640" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16698798, 19049517, 27984091" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16698798, 19049517, 27984091; Product type t: transporter" /codon_start=1 /transl_table=11 /product="component of the twin-arginine pre-protein translocation pathway" /protein_id="NP_388146.2" /db_xref="EnsemblGenomes-Gn:BSU02640" /db_xref="EnsemblGenomes-Tr:CAB12058" /db_xref="GOA:P42252" /db_xref="InterPro:IPR002033" /db_xref="InterPro:IPR019820" /db_xref="SubtiList:BG11175" /db_xref="UniProtKB/Swiss-Prot:P42252" /translation="MDKKETHLIGHLEELRRRIIVTLAAFFLFLITAFLFVQDIYDWL IRDLDGKLAVLGPSEILWVYMMLSGICAIAASIPVAAYQLWRFVAPALTKTERKVTLM YIPGLFALFLAGISFGYFVLFPIVLSFLTHLSSGHFETMFTADRYFRFMVNLSLPFGF LFEMPLVVMFLTRLGILNPYRLAKARKLSYFLLIVVSILITPPDFISDFLVMIPLLVL FEVSVTLSAFVYKKRMREETAAAA*" /label="tatCD CDS" gene 267615..268343 /gene="tatCD" /locus_tag="BSU_02640" /old_locus_tag="BSU02640" /label="tatCD gene" downshifts complement(267623) /Source="Nicolas_upshifts" /id="D106" /incds=0 /nref=4 /ntot=146 /MaxReadThrough="1.2763" /MaxDrop="3.13944" /score="-9.00478071" /energy="-8.5" /TU="NA" /idTUdmin="U190" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" CDS complement(268340..268987) /gene="pcp" /locus_tag="BSU_02650" /old_locus_tag="BSU02650" /EC_number="3.4.19.3" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1362573, 28830929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1362573, 28830929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyrrolidone-carboxylate (pyroglutamate) peptidase" /protein_id="NP_388147.1" /db_xref="EnsemblGenomes-Gn:BSU02650" /db_xref="EnsemblGenomes-Tr:CAB12059" /db_xref="GOA:P28618" /db_xref="InterPro:IPR000816" /db_xref="InterPro:IPR016125" /db_xref="InterPro:IPR029762" /db_xref="InterPro:IPR033693" /db_xref="InterPro:IPR033694" /db_xref="InterPro:IPR036440" /db_xref="SubtiList:BG10873" /db_xref="UniProtKB/Swiss-Prot:P28618" /translation="MRKKVLITGFDPFDKETVNPSWEAAKRLNGFETEEAIITAEQIP TVFRSALDTLRQAIQKHQPDIVICVGQAGGRMQITPERVAINLADARIPDNEGHQPID EEISPDGPAAYWTRLPVKRMTAKMKEHGIPAAVSYTAGTFVCNYLFYGLMDHISRTSP HIRGGFIHIPYIPQQTIDKTAPSLSLDTIVRALRIAAVTAAQYDEDVKSPGGTLH*" /label="pcp CDS" gene complement(268340..268987) /gene="pcp" /locus_tag="BSU_02650" /old_locus_tag="BSU02650" /label="pcp gene" promotor_-10 complement(269002..269021) /Source="Nicolas_upshift_promotors" /id="U190" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.487512487512487" /psig="0.957042957042957" /xcortree=559 /SigmaFactorBS="aaatgctccattatgattcactcctttacattatttTGATGa aaaacccataaatAAACAATAGAATAAAAGAAAaaggagatgggagaatgagaaaaaa a" /listShort="pcp" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 269015..269021 /Source="Nicolas_upshift_promotors" /id="U191" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.603396603396603" /psig="0.988011988011988" /xcortree=2718 /SigmaFactorBS="tttttctcattctcccatctcctttttcttttattctATTGT TTatttatgggtttttCATCAAAATAATGTAAAGGAgtgaatcataatggagcatttg c" /listShort="ycbU" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(269016) /Source="Nicolas_upshifts" /id="U190" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.487512487512487" /psig="0.957042957042957" /xcortree=559 /SigmaFactorBS="aaatgctccattatgattcactcctttacattatttTGATGa aaaacccataaatAAACAATAGAATAAAAGAAAaaggagatgggagaatgagaaaaaa a" /listShort="pcp" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(269036..269040) /Source="Nicolas_upshift_promotors" /id="U190" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.487512487512487" /psig="0.957042957042957" /xcortree=559 /SigmaFactorBS="aaatgctccattatgattcactcctttacattatttTGATGa aaaacccataaatAAACAATAGAATAAAAGAAAaaggagatgggagaatgagaaaaaa a" /listShort="pcp" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 269036..269055 /Source="Nicolas_upshift_promotors" /id="U191" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.603396603396603" /psig="0.988011988011988" /xcortree=2718 /SigmaFactorBS="tttttctcattctcccatctcctttttcttttattctATTGT TTatttatgggtttttCATCAAAATAATGTAAAGGAgtgaatcataatggagcatttg c" /listShort="ycbU" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 269038 /Source="Nicolas_upshifts" /id="U191" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.603396603396603" /psig="0.988011988011988" /xcortree=2718 /SigmaFactorBS="tttttctcattctcccatctcctttttcttttattctATTGT TTatttatgggtttttCATCAAAATAATGTAAAGGAgtgaatcataatggagcatttg c" /listShort="ycbU" /GFF_Attribute="listLong" /label="upshifts" CDS 269066..270178 /gene="ycbU" /locus_tag="BSU_02660" /old_locus_tag="BSU02660" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lyase (PLP-dependent)" /protein_id="NP_388148.2" /db_xref="EnsemblGenomes-Gn:BSU02660" /db_xref="EnsemblGenomes-Tr:CAB12060" /db_xref="GOA:P42253" /db_xref="InterPro:IPR000192" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR020578" /db_xref="SubtiList:BG11176" /db_xref="UniProtKB/Swiss-Prot:P42253" /translation="MEHLPEQYRQLFPTLQTHTMLASCSQSALAEPVSRAIQDYYDSL LYKGTNWKEAIEKTEFARNEFAKLIGAEPDEVAIVPSVSDALVSVASSLTAFGKKHVV YTDMDFPAVPHVWQAHSDYTVSVIPSIDGVLPLEQYETHISDETVLTCVPHVHYRDGY VQDIKAIAEISQRKGSLLFVDAYQSAGHIPIDVKEWGVDMLAAGTRKYLLGIPGVAFL YVRKELADALKPKASAWFGRESGFDGAYAKVARRFQTGTPAFISVYAAAAALSLLNHI GVSHIRDHVKTICADAVQYAAEKGLQLAAAQGGIQPGMVAIRDERASETAGLLKKKKV ICAPRENVIRLAPHFYNTKEEMRHAIDEIAAKTIHK*" /label="ycbU CDS" gene 269066..270178 /gene="ycbU" /locus_tag="BSU_02660" /old_locus_tag="BSU02660" /label="ycbU gene" upshifts complement(269412) /Source="Nicolas_upshifts" /id="U192" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=2851 /SigmaFactorBS="tcaagcggcagcacgccgTCTATtgatggaatgacggaTACG GTATAATCGGAGTGTGcctgccaaacatgaggcaccgccggaaaatccatatctgtat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(269415..269434) /Source="Nicolas_upshift_promotors" /id="U192" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=2851 /SigmaFactorBS="tcaagcggcagcacgccgTCTATtgatggaatgacggaTACG GTATAATCGGAGTGTGcctgccaaacatgaggcaccgccggaaaatccatatctgtat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(269450..269454) /Source="Nicolas_upshift_promotors" /id="U192" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=2851 /SigmaFactorBS="tcaagcggcagcacgccgTCTATtgatggaatgacggaTACG GTATAATCGGAGTGTGcctgccaaacatgaggcaccgccggaaaatccatatctgtat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 270172 /Source="Nicolas_upshifts" /id="D107" /incds=0 /nref=45 /ntot=226 /MaxReadThrough="1.10091" /MaxDrop="4.52742" /score="6.75687898" /energy="-14" /TU="NA" /idTUdmin="U191" /TUdmin=814 /isTUend="FALSE" /label="downshifts" CDS complement(270220..271659) /gene="lmrB" /locus_tag="BSU_02670" /old_locus_tag="BSU02670" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15317768, 15849754, 16850406, 17483215" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15317768, 15849754, 16850406, 17483215; Product type t: transporter" /codon_start=1 /transl_table=11 /product="flavonoid efflux transporter; drug-export protein" /protein_id="NP_388149.1" /db_xref="EnsemblGenomes-Gn:BSU02670" /db_xref="EnsemblGenomes-Tr:CAB12061" /db_xref="GOA:O35018" /db_xref="InterPro:IPR004638" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12613" /db_xref="UniProtKB/Swiss-Prot:O35018" /translation="MILETTAKASQQYKVMPIMISLLLAGFIGMFSETALNIALTDLM KELNITAATVQWLTTGYLLVLGILVPVSGLLLQWFTTRQLFTVSLIFSILGTFIAALA PSFSFLLAARIVQALGTGLLLPLMFNTILVIFPPHKRGAAMGTIGLVIMFAPAIGPTF SGLVLEHLNWHWIFWISLPFLVLALVFGIAYMQNVSETTKPKIDVLSIILSTIGFGGI VFGFSNAGEGSGGWSSPTVIVSLIVGVVGLILFSIRQLTMKQPMMNLRAFKYPMFILG VIMVFICMMVILSSMLLLPMYLQGGLVLTAFASGLVLLPGGILNGFMSPVTGRLFDKY GPKWLVIPGFVIVTVVLWFFSNVTTTSTAVLIIILHTCLMIGISMIMMPAQTNGLNQL PREFYPDGTAIMNTLQQMAGAIGTAVAVSIMAAGQHDYMSTVKNPADPAVIPQALTAG VQHAFVFAMIVAIIGLIGAFFMKRVKVDH*" /label="lmrB CDS" gene complement(270220..271659) /gene="lmrB" /locus_tag="BSU_02670" /old_locus_tag="BSU02670" /label="lmrB gene" downshifts complement(270227) /Source="Nicolas_upshifts" /id="D108" /incds=0 /nref=162 /ntot=245 /MaxReadThrough="0.65833" /MaxDrop="6.75228" /score="18.3484535" /energy="-14" /TU="U193" /idTUdmin="U193" /TUdmin="-23" /isTUend="FALSE" /label="downshifts" CDS complement(271699..272265) /gene="lmrA" /locus_tag="BSU_02680" /old_locus_tag="BSU02680" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12718394, 15317768, 17483215" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12718394, 15317768, 17483215; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of lmrAB and yxaGH operons (flavonoid and antibiotic resistance)" /protein_id="NP_388150.1" /db_xref="EnsemblGenomes-Gn:BSU02680" /db_xref="EnsemblGenomes-Tr:CAB12062" /db_xref="GOA:O34619" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG12612" /db_xref="UniProtKB/Swiss-Prot:O34619" /translation="MSYGDSREKILSAATRLFQLQGYYGTGLNQIIKESGAPKGSLYY HFPGGKEQLAIEAVNEMKEYIRQKIADCMEACTDPAEGIQAFLKELSCQFSCTEDIEG LPVGLLAAETSLKSEPLREACHEAYKEWASVYEEKLRQTGCSESRAKEASTVVNAMIE GGILLSLTAKNSTPLLHISSCIPDLLKR*" /label="lmrA CDS" gene complement(271699..272265) /gene="lmrA" /locus_tag="BSU_02680" /old_locus_tag="BSU02680" /label="lmrA gene" promotor_-10 complement(272303..272322) /Source="Nicolas_upshift_promotors" /id="U193" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2398 /SigmaFactorBS="cttctttttttgtcttttcatacaatgaattttTCTTGACAa ttgatgattgaatCAAGATAATAGACCAGTCACtatatttttgattgcaattcagtaa g" /listShort="lmrA, lmrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(272317) /Source="Nicolas_upshifts" /id="U193" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2398 /SigmaFactorBS="cttctttttttgtcttttcatacaatgaattttTCTTGACAa ttgatgattgaatCAAGATAATAGACCAGTCACtatatttttgattgcaattcagtaa g" /listShort="lmrA, lmrB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(272337..272344) /Source="Nicolas_upshift_promotors" /id="U193" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2398 /SigmaFactorBS="cttctttttttgtcttttcatacaatgaattttTCTTGACAa ttgatgattgaatCAAGATAATAGACCAGTCACtatatttttgattgcaattcagtaa g" /listShort="lmrA, lmrB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 272419..272425 /Source="Nicolas_upshift_promotors" /id="U194" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.368631368631369" /psig="0.652347652347652" /xcortree=316 /SigmaFactorBS="acaaaaaatactgagagaaaagctgactgatcTTTTGACtga atagataaaatgTACAATGATTAATCATCAtatggatgtaaggagagaaatagatgaa a" /listShort="ansZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 272441..272458 /Source="Nicolas_upshift_promotors" /id="U194" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.368631368631369" /psig="0.652347652347652" /xcortree=316 /SigmaFactorBS="acaaaaaatactgagagaaaagctgactgatcTTTTGACtga atagataaaatgTACAATGATTAATCATCAtatggatgtaaggagagaaatagatgaa a" /listShort="ansZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 272447 /Source="Nicolas_upshifts" /id="U194" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.368631368631369" /psig="0.652347652347652" /xcortree=316 /SigmaFactorBS="acaaaaaatactgagagaaaagctgactgatcTTTTGACtga atagataaaatgTACAATGATTAATCATCAtatggatgtaaggagagaaatagatgaa a" /listShort="ansZ" /GFF_Attribute="listLong" /label="upshifts" CDS 272482..273609 /gene="ansZ" /locus_tag="BSU_02690" /old_locus_tag="BSU02690" /EC_number="3.5.1.1" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11914346, 17686772" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11914346, 17686772; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-asparaginase 2 (putative lipoprotein)" /protein_id="NP_388151.1" /db_xref="EnsemblGenomes-Gn:BSU02690" /db_xref="EnsemblGenomes-Tr:CAB12063" /db_xref="GOA:O34482" /db_xref="InterPro:IPR004550" /db_xref="InterPro:IPR006034" /db_xref="InterPro:IPR020827" /db_xref="InterPro:IPR027473" /db_xref="InterPro:IPR027474" /db_xref="InterPro:IPR027475" /db_xref="InterPro:IPR036152" /db_xref="InterPro:IPR037152" /db_xref="SubtiList:BG12755" /db_xref="UniProtKB/Swiss-Prot:O34482" /translation="MKKQRMLVLFTALLFVFTGCSHSPETKESPKEKAQTQKVSSASA SEKKDLPNIRILATGGTIAGADQSKTSTTEYKAGVVGVESLIEAVPEMKDIANVSGEQ IVNVGSTNIDNKILLKLAKRINHLLASDDVDGIVVTHGTDTLEETAYFLNLTVKSDKP VVIVGSMRPSTAISADGPSNLYNAVKVAGAPEAKGKGTLVVLNDRIASARYVTKTNTT TTDTFKSEEMGFVGTIADDIYFNNEITRKHTKDTDFSVSNLDELPQVDIIYGYQNDGS YLFDAAVKAGAKGIVFAGSGNGSLSDAAEKGADSAVKKGVTVVRSTRTGNGVVTPNQD YAEKDLLASNSLNPQKARMLLMLALTKTNDPQKIQAYFNEY*" /label="ansZ CDS" gene 272482..273609 /gene="ansZ" /locus_tag="BSU_02690" /old_locus_tag="BSU02690" /label="ansZ gene" downshifts 273582 /Source="Nicolas_upshifts" /id="D109" /incds=0 /nref=3 /ntot=26 /MaxReadThrough="1.70459" /MaxDrop="4.27333" /score="23.2201078" /energy="-7.6" /TU="NA" /idTUdmin="U194" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 273706..273712 /Source="Nicolas_upshift_promotors" /id="U195" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.455544455544456" /psig=1 /xcortree=3077 /SigmaFactorBS="tctgaatcttaaaatttctttaaaaataagccaaaattacCC TTTACttaattaatttggTAACGTAATATAATTGGAGAatttgttacaaaaaaaggag g" /listShort="estA, S100, yccF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 273726..273745 /Source="Nicolas_upshift_promotors" /id="U195" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.455544455544456" /psig=1 /xcortree=3077 /SigmaFactorBS="tctgaatcttaaaatttctttaaaaataagccaaaattacCC TTTACttaattaatttggTAACGTAATATAATTGGAGAatttgttacaaaaaaaggag g" /listShort="estA, S100, yccF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 273726 /Source="Nicolas_upshifts" /id="U195" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.455544455544456" /psig=1 /xcortree=3077 /SigmaFactorBS="tctgaatcttaaaatttctttaaaaataagccaaaattacCC TTTACttaattaatttggTAACGTAATATAATTGGAGAatttgttacaaaaaaaggag g" /listShort="estA, S100, yccF" /GFF_Attribute="listLong" /label="upshifts" CDS 273772..274410 /gene="estA" /locus_tag="BSU_02700" /old_locus_tag="BSU02700" /EC_number="3.1.1.3" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8396026, 15812018, 18053819, 11029590, 24827611, 28963005" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8396026, 15812018, 18053819, 11029590, 24827611, 28963005; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="secreted alkaliphilic lipase" /protein_id="NP_388152.1" /db_xref="EnsemblGenomes-Gn:BSU02700" /db_xref="EnsemblGenomes-Tr:CAB12064" /db_xref="GOA:P37957" /db_xref="InterPro:IPR002918" /db_xref="InterPro:IPR029058" /db_xref="PDB:1I6W" /db_xref="PDB:1ISP" /db_xref="PDB:1R4Z" /db_xref="PDB:1R50" /db_xref="PDB:1T2N" /db_xref="PDB:1T4M" /db_xref="PDB:2QXT" /db_xref="PDB:2QXU" /db_xref="PDB:3D2A" /db_xref="PDB:3D2B" /db_xref="PDB:3D2C" /db_xref="PDB:3QMM" /db_xref="PDB:3QZU" /db_xref="PDB:5CRI" /db_xref="PDB:5CT4" /db_xref="PDB:5CT5" /db_xref="PDB:5CT6" /db_xref="PDB:5CT8" /db_xref="PDB:5CT9" /db_xref="PDB:5CTA" /db_xref="PDB:5CUR" /db_xref="SubtiList:BG10679" /db_xref="UniProtKB/Swiss-Prot:P37957" /translation="MKFVKRRIIALVTILMLSVTSLFALQPSAKAAEHNPVVMVHGIG GASFNFAGIKSYLVSQGWSRDKLYAVDFWDKTGTNYNNGPVLSRFVQKVLDETGAKKV DIVAHSMGGANTLYYIKNLDGGNKVANVVTLGGANRLTTGKALPGTDPNQKILYTSIY SSADMIVMNYLSRLDGARNVQIHGVGHIGLLYSSQVNSLIKEGLNGGGQNTN*" /label="estA CDS" gene 273772..274410 /gene="estA" /locus_tag="BSU_02700" /old_locus_tag="BSU02700" /label="estA gene" downshifts 274396 /Source="Nicolas_upshifts" /id="D110" /incds=0 /nref=15 /ntot=117 /MaxReadThrough="4.54554" /MaxDrop="4.10395" /score="23.2201078" /energy="-7.6" /TU="U195" /idTUdmin="U194" /TUdmin=814 /isTUend="FALSE" /label="downshifts" S_feature 274441..275031 /Source="Nicolas_S_feature" /locus_tag="new_292874_293464" /HighExp="M9-tran, GM 150, LoTm, MG 150, GM 120, aero, T-1.40H, M/G, S2, GM 90" /AntisenseName="yczC" /AntisenseCor="3.5651747957185502E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S100" CDS complement(274448..274831) /gene="yczC" /locus_tag="BSU_02710" /old_locus_tag="BSU02710" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406; Product type m:membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein of unknown function" /protein_id="NP_388153.1" /db_xref="EnsemblGenomes-Gn:BSU02710" /db_xref="EnsemblGenomes-Tr:CAB12065" /db_xref="GOA:O31469" /db_xref="InterPro:IPR010432" /db_xref="SubtiList:BG12778" /db_xref="UniProtKB/Swiss-Prot:O31469" /translation="MELAGFMLRACALLLDVIIAAAVILAAGFTFGDGSAGVIIVAIL MLIVYPLLMPLTNWKGTLGKKIIGLQIVRDETYKKISFPQAIVRYLIAWVHVFSRLIY LTAAFTKKKQTVHDMAAKTIVLKAE*" /label="yczC CDS" gene complement(274448..274831) /gene="yczC" /locus_tag="BSU_02710" /old_locus_tag="BSU02710" /label="yczC gene" downshifts complement(274472) /Source="Nicolas_upshifts" /id="D111" /incds=0 /nref=4 /ntot=94 /MaxReadThrough="0.85389" /MaxDrop="2.7858" /score="15.0330092" /energy="-12.1" /TU="NA" /idTUdmin="U196" /TUdmin=0 /isTUend="TRUE" /label="downshifts" Polymorphism join(274645,274647) /Source="geneious" /ID="SNP_BsDelta6_293079_293079" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change /CDS_Position=186 /Change="C -> T" /Codon_Change="CTG -> CTA" /Coverage=154 /locus_tag="BSU_02710" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=154 /comment="silent" /modified_by="User" / /label="Polymorphism_Delta6" promotor_-10 complement(274861..274880) /Source="Nicolas_upshift_promotors" /id="U196" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.507492507492508" /psig="0.835164835164835" /xcortree=3082 /SigmaFactorBS="aacttttgtgatttaaggcttatcaccTATTCCCActttagg cccttcTTTTTTACAATCATTAGGTGtttatttaacattttaaggagtgtttctattg g" /listShort="yczC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(274868) /Source="Nicolas_upshifts" /id="U196" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.507492507492508" /psig="0.835164835164835" /xcortree=3082 /SigmaFactorBS="aacttttgtgatttaaggcttatcaccTATTCCCActttagg cccttcTTTTTTACAATCATTAGGTGtttatttaacattttaaggagtgtttctattg g" /listShort="yczC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(274894..274901) /Source="Nicolas_upshift_promotors" /id="U196" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.507492507492508" /psig="0.835164835164835" /xcortree=3082 /SigmaFactorBS="aacttttgtgatttaaggcttatcaccTATTCCCActttagg cccttcTTTTTTACAATCATTAGGTGtttatttaacattttaaggagtgtttctattg g" /listShort="yczC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 275003..275006 /Source="Nicolas_upshift_promotors" /id="U197" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.916083916083916" /psig="0.999000999001" /xcortree=2575 /SigmaFactorBS="acattaccaaattcttttttagcccgaaacCAAGccctcaga agttattTTTGTTAAAATAGAAAAGTTacaacagaattcggagggtttattgtgggaa a" /listShort="yccF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 275022..275041 /Source="Nicolas_upshift_promotors" /id="U197" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.916083916083916" /psig="0.999000999001" /xcortree=2575 /SigmaFactorBS="acattaccaaattcttttttagcccgaaacCAAGccctcaga agttattTTTGTTAAAATAGAAAAGTTacaacagaattcggagggtttattgtgggaa a" /listShort="yccF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 275033 /Source="Nicolas_upshifts" /id="U197" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.916083916083916" /psig="0.999000999001" /xcortree=2575 /SigmaFactorBS="acattaccaaattcttttttagcccgaaacCAAGccctcaga agttattTTTGTTAAAATAGAAAAGTTacaacagaattcggagggtttattgtgggaa a" /listShort="yccF" /GFF_Attribute="listLong" /label="upshifts" CDS 275066..276142 /gene="yccF" /locus_tag="BSU_02720" /old_locus_tag="BSU02720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388154.1" /db_xref="EnsemblGenomes-Gn:BSU02720" /db_xref="EnsemblGenomes-Tr:CAB12066" /db_xref="GOA:O34478" /db_xref="InterPro:IPR004027" /db_xref="InterPro:IPR007889" /db_xref="InterPro:IPR036915" /db_xref="SubtiList:BG12756" /db_xref="UniProtKB/Swiss-Prot:O34478" /translation="MGKVKRNAPCPCGSGKKYKKCCGSKVVDFPAELAAKEAKQIQED LVEYAFTVHRESISGFINQHDFLSAMDRQTKDISVFNLGIWGIFFHPLAGEKTIFEEY LQKKGDSITRPKTREIVESWQSMTPALLLLKDLKEGIIHFEDVITAKQFEVEMDASNQ DLPPVGSLILGYPIHEAEKAEFFMQFTIFPVKRTEALISKVKKYADAAVKDGKTPEDF MKQEFNNVLFALLAEKDEEPQAEKAEVSTVEWANDLEKETAAAIEEGMSGEEYPTELI PAVIDIWKTFCEKKSPVIRKPEAFAAAVEYYVNAISLNGASVSQAKLAKKYGVSASTI SSRYKEIESTLQDEADRFAQALSS*" /label="yccF CDS" gene 275066..276142 /gene="yccF" /locus_tag="BSU_02720" /old_locus_tag="BSU02720" /label="yccF gene" downshifts 276136 /Source="Nicolas_upshifts" /id="D112" /incds=0 /nref=60 /ntot=248 /MaxReadThrough="1.55048" /MaxDrop="5.18328" /score="33.0000484" /energy="-12.9" /TU="NA" /idTUdmin="U197" /TUdmin=2 /isTUend="TRUE" /label="downshifts" CDS complement(276182..277138) /gene="natK" /locus_tag="BSU_02730" /old_locus_tag="BSU02730" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 17322186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 17322186; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [NatR]" /protein_id="NP_388155.1" /db_xref="EnsemblGenomes-Gn:BSU02730" /db_xref="EnsemblGenomes-Tr:CAB12067" /db_xref="GOA:P70954" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR032834" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11997" /db_xref="UniProtKB/Swiss-Prot:P70954" /translation="MITLFQCLYLILFSFICYQGAAAFSHSTAASWLAAALGAAAAGL YIWNTKRVWKHCSSGLCAWIAVIQVMSVGVVLIGTDIMPVLCVIAIFAGCEGLRIGQS ALQARLSDQIDKLTQAEQHANQMLIDVRSRNHDTMKHITAIKSAQPKADTQAYIQNWA DQYSQYDRFLKGENAYVAGVLYDFLEKARASNVSVSLHMHTPLSSLPFSPADQVSLVG NILENALDSAAEAREKAEIKLETSLRSGLYVLTCENSTPGMDPKVLDTIYQSFGRSTK NGAHEGMGTYIIQKLVKGAFGRLDFTYRHPIFRLEIKIPFQK*" /label="natK CDS" gene complement(276182..277138) /gene="natK" /locus_tag="BSU_02730" /old_locus_tag="BSU02730" /label="natK gene" downshifts complement(276210) /Source="Nicolas_upshifts" /id="D113" /incds=0 /nref=1 /ntot=129 /MaxReadThrough="0.86926" /MaxDrop="2.67125" /score="14.02819" /energy="-12.9" /TU="NA" /idTUdmin="U198" /TUdmin=176 /isTUend="FALSE" /label="downshifts" CDS complement(277151..277852) /gene="natR" /locus_tag="BSU_02740" /old_locus_tag="BSU02740" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 17322186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 17322186; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [NatK]" /protein_id="NP_388156.1" /db_xref="EnsemblGenomes-Gn:BSU02740" /db_xref="EnsemblGenomes-Tr:CAB12068" /db_xref="GOA:P70955" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR007492" /db_xref="InterPro:IPR011006" /db_xref="SubtiList:BG11998" /db_xref="UniProtKB/Swiss-Prot:P70955" /translation="MVKVGLVDDYRVDLEKLEAIVSRMQDVEIVFSTDSAKEAYRRVK NGDIDLLLADIEMPHMSGYELADLIKSHSLDVDVIFVTGHGGYAVHAFDLNVHDYIMK PYYADRLAASFDRYLKKKTETSLNGRILIKQKSEMHVLQKKDIIFAERTGRSTTIVTT AEEVQTYQTLNDIKGDLPEKDFLRSHRSFIINIHYIKHFSAYTKHSFTVSFEGTSKKA MITKQQLDYFQNYYF*" /label="natR CDS" gene complement(277151..277852) /gene="natR" /locus_tag="BSU_02740" /old_locus_tag="BSU02740" /label="natR gene" promotor_-10 complement(277876..277895) /Source="Nicolas_upshift_promotors" /id="U198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.397602397602398" /psig="0.992007992007992" /xcortree=2173 /SigmaFactorBS="attagttggataaagttgtcgcgaagagTTCTttttatgtcg tgaaaTGGGATAGAATAAAGATGATtctatgtaactaggggaatgataatggtaaaag t" /listShort="natR, natK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(277882) /Source="Nicolas_upshifts" /id="U198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.397602397602398" /psig="0.992007992007992" /xcortree=2173 /SigmaFactorBS="attagttggataaagttgtcgcgaagagTTCTttttatgtcg tgaaaTGGGATAGAATAAAGATGATtctatgtaactaggggaatgataatggtaaaag t" /listShort="natR, natK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(277911..277914) /Source="Nicolas_upshift_promotors" /id="U198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.397602397602398" /psig="0.992007992007992" /xcortree=2173 /SigmaFactorBS="attagttggataaagttgtcgcgaagagTTCTttttatgtcg tgaaaTGGGATAGAATAAAGATGATtctatgtaactaggggaatgataatggtaaaag t" /listShort="natR, natK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 277932..277935 /Source="Nicolas_upshift_promotors" /id="U199" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.356643356643357" /psig="0.844155844155844" /xcortree=1785 /SigmaFactorBS="cgacataaaaagaactcttcgcgacaactttATCCaactaat ccagctttTCGTATATAGTCATTACTAGaaataaagataagggagattgtgacatgat t" /listShort="natA, natB, yccK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 277951..277970 /Source="Nicolas_upshift_promotors" /id="U199" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.356643356643357" /psig="0.844155844155844" /xcortree=1785 /SigmaFactorBS="cgacataaaaagaactcttcgcgacaactttATCCaactaat ccagctttTCGTATATAGTCATTACTAGaaataaagataagggagattgtgacatgat t" /listShort="natA, natB, yccK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 277961 /Source="Nicolas_upshifts" /id="U199" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.356643356643357" /psig="0.844155844155844" /xcortree=1785 /SigmaFactorBS="cgacataaaaagaactcttcgcgacaactttATCCaactaat ccagctttTCGTATATAGTCATTACTAGaaataaagataagggagattgtgacatgat t" /listShort="natA, natB, yccK" /GFF_Attribute="listLong" /label="upshifts" CDS 277996..278736 /gene="natA" /locus_tag="BSU_02750" /old_locus_tag="BSU02750" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10356997, 17322186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10356997, 17322186; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Na+ ABC efflux transporter (ATP-binding protein)" /protein_id="NP_388157.1" /db_xref="EnsemblGenomes-Gn:BSU02750" /db_xref="EnsemblGenomes-Tr:CAB12069" /db_xref="GOA:P46903" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11338" /db_xref="UniProtKB/Swiss-Prot:P46903" /translation="MITLTDCSRRFQDKKKVVKAVRDVSLTIEKGEVVGILGENGAGK TTMLRMIASLLEPSQGVITVDGFDTVKQPAEVKQRIGVLFGGETGLYDRMTAKENLQY FGRLYGLNRHEIKARIEDLSKRFGMRDYMNRRVGGFSKGMRQKVAIARALIHDPDIIL FDEPTTGLDITSSNIFREFIQQLKREQKTILFSSHIMEEVQALCDSVIMIHSGEVIYR GALESLYESERSEDLNYIFMSKLVRGIS*" /label="natA CDS" gene 277996..278736 /gene="natA" /locus_tag="BSU_02750" /old_locus_tag="BSU02750" /label="natA gene" CDS 278737..279897 /gene="natB" /locus_tag="BSU_02760" /old_locus_tag="BSU02760" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10356997, 15849754, 16850406, 17322186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10356997, 15849754, 16850406, 17322186; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Na+ ABC efflux transporter (permease)" /protein_id="NP_388158.1" /db_xref="EnsemblGenomes-Gn:BSU02760" /db_xref="EnsemblGenomes-Tr:CAB12070" /db_xref="GOA:P46904" /db_xref="InterPro:IPR032688" /db_xref="SubtiList:BG11339" /db_xref="UniProtKB/Swiss-Prot:P46904" /translation="MLSHIYKKEMIDALRDRKTILLTILVPMIMMLGLVFFYESMLSD KGEQYTLAVGHSLPPALESKLNEIDEISVKTFAKPEEAVDEGKADAYLNVPKEFDSYV NSMTPFKVDVYGNSIDQGSSNAMQLVQSALDQYKNEIVQQRLTNKHIDQSVIQPFTIQ QKEADEEKGTSAIMLSAILPMLILTSIVSGAMPIALDIMAGEKDRKSIEALLLTPVSR NKVLVGKWLAVSTFGVASGVFALVFLILSTVLFTENLKTAFQLGDHMWSVIGASALII VLSALLISAMELFISIMSSSVKEAQSYMSLVVFLPVFPMFFIFSKAPNQFDLSYFLIP FLNLHALFKQLLFGMVDPATILSTSGTIAVLIAIFFLLARACFLKDKWVLPK*" /label="natB CDS" gene 278737..279897 /gene="natB" /locus_tag="BSU_02760" /old_locus_tag="BSU02760" /label="natB gene" promotor_-35 279948..279956 /Source="Nicolas_upshift_promotors" /id="U200" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=430 /SigmaFactorBS="ggagaaatacactttctcctttttgtatatcctgaaaaaaGA AGGAAAAtagaaaaaggaTATCTAATACAAAAAGTGAccctgcactatttttcatcaa a" /listShort="yccK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 279968..279986 /Source="Nicolas_upshift_promotors" /id="U200" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=430 /SigmaFactorBS="ggagaaatacactttctcctttttgtatatcctgaaaaaaGA AGGAAAAtagaaaaaggaTATCTAATACAAAAAGTGAccctgcactatttttcatcaa a" /listShort="yccK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 279968 /Source="Nicolas_upshifts" /id="U200" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=430 /SigmaFactorBS="ggagaaatacactttctcctttttgtatatcctgaaaaaaGA AGGAAAAtagaaaaaggaTATCTAATACAAAAAGTGAccctgcactatttttcatcaa a" /listShort="yccK" /GFF_Attribute="listLong" /label="upshifts" CDS 280033..280965 /gene="yccK" /locus_tag="BSU_02770" /old_locus_tag="BSU02770" /EC_number="1.-.-.-" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17322186, 24330391; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ion channel associated aldo-keto reductase" /protein_id="NP_388159.1" /db_xref="EnsemblGenomes-Gn:BSU02770" /db_xref="EnsemblGenomes-Tr:CAB12071" /db_xref="GOA:P46905" /db_xref="InterPro:IPR020471" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="SubtiList:BG11340" /db_xref="UniProtKB/Swiss-Prot:P46905" /translation="MDQTRTLGKTKLKVKRIGFGANAVGGHNLFPNLNDETGKDLVRT ALDGGVNFIDTAFIYGLGRSEELIGEVVQERGVRNELIIATKGAHKEVDGSIELDNSR EFLRSEVEKSLKRLKTDYIDLYYVHFPDGKTPLAEVAGTLKELKDEGKIKAIGASNLD YQQLQDFNADGYLEVFQAEYSLIQRDAEKELLPYCEKQGISFIPYFPLASGLLTGKFT QDTVFDDFRKDKPQFQGETFIHNLKKVDKLKAVAEEKQADTAHVALAWLLTRPAIDAI IPGAKRPEQLQDNLKTLNIELTEDEVNFISDIFK*" /label="yccK CDS" gene 280033..280965 /gene="yccK" /locus_tag="BSU_02770" /old_locus_tag="BSU02770" /label="yccK gene" CDS complement(281005..282069) /gene="ycdA" /locus_tag="BSU_02780" /old_locus_tag="BSU02780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 22496484; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="lipoprotein involved in swarming behaviour" /protein_id="NP_388160.1" /db_xref="EnsemblGenomes-Gn:BSU02780" /db_xref="EnsemblGenomes-Tr:CAB12072" /db_xref="GOA:O34538" /db_xref="InterPro:IPR029050" /db_xref="InterPro:IPR029051" /db_xref="InterPro:IPR031343" /db_xref="PDB:4R4G" /db_xref="SubtiList:BG12757" /db_xref="UniProtKB/Swiss-Prot:O34538" /translation="MFQKKTYAVFLILLLMMFTAACSGSKTSAEKKESETEKSSDIAQ VKIKDVSYTLPSKYDKSTSDDQLVLKVNVAVKNTGKDPLNVDSMDFTLYQGDTKMSDT DPEDYSEKLQGSTINADKSVEGNLFFVVDKGKQYELNYTPESYGDKKPKSVTFKIDGK DKKILATADKLQDSAKALSAYVDVLLFGKDNADFEKITGANKNEIVNDFNESAKDGYL SASGLSSTYADSKALDNIVNGIKEGLSKNSSIQAKTTSISKDEAIVEATVKPVDASSL SDRIEDKVKDYYSKNSSASYEEAVKYALQVYPEEFKKLGPASSEKTVEVKMKKNDIDQ WQLDMDDYRAAELVEAFIKE*" /label="ycdA CDS" gene complement(281005..282069) /gene="ycdA" /locus_tag="BSU_02780" /old_locus_tag="BSU02780" /label="ycdA gene" downshifts complement(281006) /Source="Nicolas_upshifts" /id="D114" /incds=0 /nref=198 /ntot=222 /MaxReadThrough="0.57029" /MaxDrop="8.85093" /score="27.0612397" /energy="-13.7" /TU="NA" /idTUdmin="U201" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(282070..282260) /Source="Nicolas_S_feature" /locus_tag="new_300503_300693_c" /HighExp="S5, S4, MG 45, MG 15, MG-0.2, MG 25, MG-0.1, MG 10, S3, MG t5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S101" CDS complement(282092..282223) /locus_tag="BSU_02785" /old_locus_tag="BSU02785" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513941.1" /translation="MTKEGGVSRKSGENREKRTDFFGYMMLIHSKRSISQRQKTPLS* " /label="hypothetical protein CDS" gene complement(282092..282223) /locus_tag="BSU_02785" /old_locus_tag="BSU02785" /label="gene" promotor_-10 complement(282245..282264) /Source="Nicolas_upshift_promotors" /id="U201" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.997002997002997" /xcortree=2915 /SigmaFactorBS="ttaccagaacatttttcaccaaaaataggatgatgaaccTAT TCAATataaaagctaataaTCTTAAAATTAATTCCGTTGtaactttttataggtccat t" /listShort="S101, ycdA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(282265) /Source="Nicolas_upshifts" /id="U201" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.997002997002997" /xcortree=2915 /SigmaFactorBS="ttaccagaacatttttcaccaaaaataggatgatgaaccTAT TCAATataaaagctaataaTCTTAAAATTAATTCCGTTGtaactttttataggtccat t" /listShort="S101, ycdA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(282279..282286) /Source="Nicolas_upshift_promotors" /id="U201" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.997002997002997" /xcortree=2915 /SigmaFactorBS="ttaccagaacatttttcaccaaaaataggatgatgaaccTAT TCAATataaaagctaataaTCTTAAAATTAATTCCGTTGtaactttttataggtccat t" /listShort="S101, ycdA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 282397..283815 /gene="ycdB" /locus_tag="BSU_02790" /old_locus_tag="BSU02790" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388161.1" /db_xref="EnsemblGenomes-Gn:BSU02790" /db_xref="EnsemblGenomes-Tr:CAB12073" /db_xref="InterPro:IPR032599" /db_xref="SubtiList:BG12758" /db_xref="UniProtKB/Swiss-Prot:O34621" /translation="MKGAAFVKKEGLKQKALEIGRVPTHLKLEIEDYGGDDKRAHFCW ADPQDENTGIIVELGPDGELESLSRDIEPESGERLSEEKLEDIMRQFVETHHPGALSA FVREENDRAYGDKVRFSYVQMEAGLPLPMSGFMADVSLSGEIVYFRYYGEAGSIIKPK RVADVEEALAFIKKDVEFDLLFEVLHRSVYKNGDDQPHLVYEPEGRAITVPADLVQEE QAVDDDDDYREPESFPLPLFEGIREKADPDSMIGIENGFVKEREADLGDGRIGIVWRN PDDPVYQPADKSMDSWFKGRTHQVLKTIYNKETGKLEGVMSFMEKKGPLTVTLAECEK IALRFLFALFPNADQYFRIRYDEKDEEENAVAGFTFEAHCHGVPLRFGQIRICVSRQT GYITVYMGPDIDPNKLATIDPVPAISVEQAKSIFWQHFKVELGWEREYGDDEEHSYRL VYKPVYPHFIDAHTGEPVFSIW*" /label="ycdB CDS" gene 282397..283815 /gene="ycdB" /locus_tag="BSU_02790" /old_locus_tag="BSU02790" /label="ycdB gene" promotor_-10 complement(283858..283876) /Source="Nicolas_upshift_promotors" /id="U202" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.685314685314685" /psig="0.96903096903097" /xcortree=2432 /SigmaFactorBS="agtgaagaaaggtccttttctattattgtCATTGTTTtttga gattctttCTGTTACTTTCATCACATActctcttctatatctgaggcaattgcgtgac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(283866) /Source="Nicolas_upshifts" /id="U202" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.685314685314685" /psig="0.96903096903097" /xcortree=2432 /SigmaFactorBS="agtgaagaaaggtccttttctattattgtCATTGTTTtttga gattctttCTGTTACTTTCATCACATActctcttctatatctgaggcaattgcgtgac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(283890..283897) /Source="Nicolas_upshift_promotors" /id="U202" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.685314685314685" /psig="0.96903096903097" /xcortree=2432 /SigmaFactorBS="agtgaagaaaggtccttttctattattgtCATTGTTTtttga gattctttCTGTTACTTTCATCACATActctcttctatatctgaggcaattgcgtgac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 283922..284001 /Source="Nicolas_S_feature" /locus_tag="new_302355_302434" /HighExp="ferm, M40t45, M0t45, Lbstat, S0, nit, LBGtran, Lbtran, G135, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.868" /TUlongSig="NA" /TUlongPSig="NA" /label="S102" upshifts 283922 /Source="Nicolas_upshifts" /id="U203" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.48051948051948" /psig="0.868131868131868" /xcortree=1586 /SigmaFactorBS="tgatgaaagtaacagaaagaatctcaaaaaacaatgacaata atagaaaaggacctttcttcACTTTAAatgaagaaaggtctTTTTATATAATAAACAG G" /listShort="S102, ycdC, S103" /listLong="rapJ" /label="upshifts" promotor_-35 283924..283930 /Source="Nicolas_upshift_promotors" /id="U203" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.48051948051948" /psig="0.868131868131868" /xcortree=1586 /SigmaFactorBS="tgatgaaagtaacagaaagaatctcaaaaaacaatgacaata atagaaaaggacctttcttcACTTTAAatgaagaaaggtctTTTTATATAATAAACAG G" /listShort="S102, ycdC, S103" /listLong="rapJ" /label="promotor_-35" promotor_-10 283945..283962 /Source="Nicolas_upshift_promotors" /id="U203" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.48051948051948" /psig="0.868131868131868" /xcortree=1586 /SigmaFactorBS="tgatgaaagtaacagaaagaatctcaaaaaacaatgacaata atagaaaaggacctttcttcACTTTAAatgaagaaaggtctTTTTATATAATAAACAG G" /listShort="S102, ycdC, S103" /listLong="rapJ" /label="promotor_-10" CDS 284002..285363 /gene="ycdC" /locus_tag="BSU_02800" /old_locus_tag="BSU02800" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388162.1" /db_xref="EnsemblGenomes-Gn:BSU02800" /db_xref="EnsemblGenomes-Tr:CAB12074" /db_xref="InterPro:IPR032599" /db_xref="SubtiList:BG12759" /db_xref="UniProtKB/Swiss-Prot:O34772" /translation="MVNKQLKKKAQEIGNVPTHYELEIEDYDQKQKKYGQAYFIWKDP KDPEKHITVELRNDGALLTFSTTVHSETDKKLPDAELKLTALQFAAANHPGTFMNFHF QGKEERGQHIRFVYTKMELGLPIPNSGFLIDMTRSGQIVHFLYYGEGHKAEVPTEFVA KEKVVSHYLNTMSFELMYDVIDGEQEPRLVYEPILPGYSYPADVDEIVPDQHIADERI ENTAPLPPLQNKEEVDIFALLGFTSDMQKVSERDFGEQIGSTWRRGAAPERKDLSIGS YFETRNKNTIKMKTDKRTGKLKAALSFMDWRNNLQCSTEECQEIALQFLYALYPRAAE FFRVNPVRIDERGRVRNHFSVWYKGVPLRFGAARIIVNPETGLIDAFMAPDIEPEQLE AINHRPDVSAEEAKEAFLAAFDVKLEWQPDFTAGSDQHCKLVYKPVYPSYIDAHIRKK KRL*" /label="ycdC CDS" gene 284002..285363 /gene="ycdC" /locus_tag="BSU_02800" /old_locus_tag="BSU02800" /label="ycdC gene" S_feature 285364..285944 /Source="Nicolas_S_feature" /locus_tag="new_303797_304377" /HighExp="ferm, M0t45, G135, G180, H2O2, M40t45, G150, Paraq, S0, nit" /AntisenseName="cwlK" /AntisenseCor="0.27553388443794402" /AntisenseRegPval="-5.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.868" /TUlongSig="NA" /TUlongPSig="NA" /label="S103" CDS complement(285371..285874) /gene="cwlK" /locus_tag="BSU_02810" /old_locus_tag="BSU02810" /EC_number="3.4.-.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17588176" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17588176; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="murein L,D:-endopeptidase" /protein_id="NP_388163.1" /db_xref="EnsemblGenomes-Gn:BSU02810" /db_xref="EnsemblGenomes-Tr:CAB12075" /db_xref="GOA:O34360" /db_xref="InterPro:IPR009045" /db_xref="SubtiList:BG12760" /db_xref="UniProtKB/Swiss-Prot:O34360" /translation="MNLPAKTFVILCILFLLDLCFSYIRHEWHSQNALQDMPVPSDLH PIVKQNADALKAAAANKGIDVVITEGFRSFKEQDELYKQGRTKKGNIVTYARGGESYH NYGLAIDFALQKKDGSIIWDMEYDGNQNGKSDWLEVVEIAKTLGFEWGGDWKRFKDYP HLEMIPN*" /label="cwlK CDS" gene complement(285371..285874) /gene="cwlK" /locus_tag="BSU_02810" /old_locus_tag="BSU02810" /label="cwlK gene" S_feature complement(285875..285956) /Source="Nicolas_S_feature" /locus_tag="new_304308_304389_c" /HighExp="Cold, T0.30H, LBGstat, C30, T-0.40H, T1.0H, T1.30H, H2O2, T0.0H, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.946" /TUlongSig="NA" /TUlongPSig="NA" /label="S104" upshifts 285946 /Source="Nicolas_upshifts" /id="U204" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2275 /SigmaFactorBS="tttctcaagatgtgctgaatgttaacgcttttaagtgattga ctctctctaaaagcgaacagcTATGATAAAATATAACATAAatagtagcaggaggaag g" /listShort="rapJ" /listLong="ycdF, ycdG, adcA, adcC, adcB" /label="upshifts" promotor_-10 complement(285948..285967) /Source="Nicolas_upshift_promotors" /id="U205" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.576423576423576" /psig="0.946053946053946" /xcortree=2433 /SigmaFactorBS="tgatggaatctttgctctcatcggtctgcctccttccTcctg ctactattTATGTTATATTTTATCATAGctgttcgcttttagagagagtcaatcactt a" /listShort="S104, cwlK" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature 285949..285968 /Source="Nicolas_upshift_promotors" /id="U204" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2275 /SigmaFactorBS="tttctcaagatgtgctgaatgttaacgcttttaagtgattga ctctctctaaaagcgaacagcTATGATAAAATATAACATAAatagtagcaggaggaag g" /listShort="rapJ" /listLong="ycdF, ycdG, adcA, adcC, adcB" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(285957) /Source="Nicolas_upshifts" /id="U205" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.576423576423576" /psig="0.946053946053946" /xcortree=2433 /SigmaFactorBS="tgatggaatctttgctctcatcggtctgcctccttccTcctg ctactattTATGTTATATTTTATCATAGctgttcgcttttagagagagtcaatcactt a" /listShort="S104, cwlK" /GFF_Attribute="listLong" /label="upshifts" CDS 285997..287118 /gene="rapJ" /locus_tag="BSU_02820" /old_locus_tag="BSU02820" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16816200" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16816200; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="response regulator aspartate phosphatase" /protein_id="NP_388164.1" /db_xref="EnsemblGenomes-Gn:BSU02820" /db_xref="EnsemblGenomes-Tr:CAB12076" /db_xref="GOA:O34327" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="PDB:4GYO" /db_xref="SubtiList:BG12663" /db_xref="UniProtKB/Swiss-Prot:O34327" /translation="MRAKIPSEEVAVKLNEWYKLIRAFEADQAEALKQEIEYDLEDME ENQDLLLYFSLMEFRHRIMLDKLMPVKDSDTKPPFSDMLNEIESNQQKLTGLLEYYFY YFRGMYEFKQKNFILAIDHYKHAEEKLEYVEDEIEKAEFLFKVAEVYYHIKQTYFSMN YASQALDIYTKYELYGRRRVQCEFIIAGNLTDVYHHEKALTHLCSALEHARQLEEAYM IAAAYYNVGHCKYSLGDYKEAEGYFKTAAAIFEEHNFQQAVQAVFSLTHIYCKEGKYD KAVEAYDRGIKSAAEWEDDMYLTKFRLIHELYLGSGDLNVLTECFDLLESRQLLADAE DLLHDTAERFNQLEHYESAAFFYRRLMNIKKKLAEQRFQ*" /label="rapJ CDS" gene 285997..287118 /gene="rapJ" /locus_tag="BSU_02820" /old_locus_tag="BSU02820" /label="rapJ gene" downshifts 287112 /Source="Nicolas_upshifts" /id="D115" /incds=0 /nref=88 /ntot=228 /MaxReadThrough="3.8438" /MaxDrop="5.06867" /score="32.2653577" /energy="-13.2" /TU="U204" /idTUdmin="U204" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" promotor_-35 287159..287165 /Source="Nicolas_upshift_promotors" /id="U206" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=187 /SigmaFactorBS="tggcagagaactacaggttctctgctttttttgtgcTGTTTT CaactcggaaaaacaGGGTATTTTCCACTGCATAgtgagaaacagaggaggatatcaa g" /listShort="ycdF, ycdG, adcA, adcC, adcB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 287180..287198 /Source="Nicolas_upshift_promotors" /id="U206" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=187 /SigmaFactorBS="tggcagagaactacaggttctctgctttttttgtgcTGTTTT CaactcggaaaaacaGGGTATTTTCCACTGCATAgtgagaaacagaggaggatatcaa g" /listShort="ycdF, ycdG, adcA, adcC, adcB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 287183 /Source="Nicolas_upshifts" /id="U206" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=187 /SigmaFactorBS="tggcagagaactacaggttctctgctttttttgtgcTGTTTT CaactcggaaaaacaGGGTATTTTCCACTGCATAgtgagaaacagaggaggatatcaa g" /listShort="ycdF, ycdG, adcA, adcC, adcB" /GFF_Attribute="listLong" /label="upshifts" CDS 287225..288001 /gene="ycdF" /locus_tag="BSU_02830" /old_locus_tag="BSU02830" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10220166, 11948145, 15805528; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388165.1" /db_xref="EnsemblGenomes-Gn:BSU02830" /db_xref="EnsemblGenomes-Tr:CAB12077" /db_xref="GOA:P80869" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12761" /db_xref="UniProtKB/Swiss-Prot:P80869" /translation="MYKDLTGKTAIVTGSSKGIGKAIAERFGKEKMNVVVNYHSDPSG ADETLEIIKQNGGKAVSVEADVSKEEGIQALLDTALEHFGTLDVMVNNSGFNGVEAMP HEMSLEDWQRVIDVNVTGTFLGAKAALNHMMKNNIKGNVLNISSVHQQIPRPVNVQYS TSKGGIKMMTETLALNYADKGIRVNAIAPGTIATESNVDTKKEESRQKQLKKIPMKAF GKPEEVAAAAAWLVSEEASYVTGATLFVDGGMTLYPSQLE*" /label="ycdF CDS" gene 287225..288001 /gene="ycdF" /locus_tag="BSU_02830" /old_locus_tag="BSU02830" /label="ycdF gene" downshifts complement(287232) /Source="Nicolas_upshifts" /id="D116" /incds=0 /nref=10 /ntot=23 /MaxReadThrough="0.31912" /MaxDrop="4.8095" /score="0.506500496" /energy="-5.8" /TU="NA" /idTUdmin="U205" /TUdmin="-1914" /isTUend="FALSE" /label="downshifts" CDS 288026..289711 /gene="ycdG" /locus_tag="BSU_02840" /old_locus_tag="BSU02840" /EC_number="3.2.1.10" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11544224; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oligo-carbohydrate hydrolase" /protein_id="NP_388166.1" /db_xref="EnsemblGenomes-Gn:BSU02840" /db_xref="EnsemblGenomes-Tr:CAB12078" /db_xref="GOA:O34364" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG12762" /db_xref="UniProtKB/Swiss-Prot:O34364" /translation="MKTDWWKDAVVYQIYPRSFQDSNGDGIGDLRGIISRLDYIKELG ADVIWICPIYPSPNVDYGYDVTNHKAIMDSYGTMDDFHELLDQVHQRGLKLVMDFVLN HTSVEHPWFKEAELDKNSKYRSYYYWRPGTKNGPPTDWLSNYGCPVWQYEEHTGEYYL HMNAVKQADLNWENPEVRQAVYDMMKFWLDKGVDGLRIDQLHLISKKEYLPSYEDYIN QQAEPKPFQPNGERIHDYLKEITDEVFSHYDVMSVGEVGSVTPEEGLKYTGTDKHELN MIFHFQHMELDQQPGKEHWDLKPLELSDLKSVLTKWQKKLEHQGWNTLFWCNHDQPRI VSRFGDDGEYRKASAKMLAAVIYFMKGTPYIYQGEEIGMTNAPFTRIEDYKDIQTINM YHKRVFEKGYDPNDVMRSILAKSRDHARTPMQWNSGKNAGFTDGTPWLKVNPNFTAIN VEEAQGDPDSVLNYYKKLISLRKQYADLMKGSFDLLLPDDPQLFVYMRENSKQQLLSV NNFSKEQAVFQWPKNCGKAQASLLLSNYNNDDLDDEMVFRPYESRVYLLDKTN*" /label="ycdG CDS" gene 288026..289711 /gene="ycdG" /locus_tag="BSU_02840" /old_locus_tag="BSU02840" /label="ycdG gene" promotor_no_box 288966..289066 /Source="Nicolas_upshift_promotors" /id="U207" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.487512487512487" /psig="0.044955044955045" /xcortree=117 /SigmaFactorBS="agaagcttgaacatcaaggctggaatacattgttttggtgca accacgaccagccccggattgtgtccagattcggagacgatggggaataccgcaaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 289026 /Source="Nicolas_upshifts" /id="U207" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.487512487512487" /psig="0.044955044955045" /xcortree=117 /SigmaFactorBS="agaagcttgaacatcaaggctggaatacattgttttggtgca accacgaccagccccggattgtgtccagattcggagacgatggggaataccgcaaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 289092 /Source="Nicolas_upshifts" /id="D117" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="7.77365" /MaxDrop="2.18547" /score="23.9074448" /energy="-10.2" /TU="U206" /idTUdmin="U204" /TUdmin=1914 /isTUend="FALSE" /label="downshifts" downshifts 289708 /Source="Nicolas_upshifts" /id="D118" /incds=0 /nref=13 /ntot=56 /MaxReadThrough="5.8252" /MaxDrop="5.18702" /score="23.9074448" /energy="-10.2" /TU="U206" /idTUdmin="U204" /TUdmin=2530 /isTUend="FALSE" /label="downshifts" promotor_-35 289802..289809 /Source="Nicolas_upshift_promotors" /id="U208" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.401598401598402" /psig="0.999000999001" /xcortree=669 /SigmaFactorBS="ggcgggaagaataaatgaaaatgaaatttatTCTTGCAAaac gtaatgacttcgGTTTATTATGATATAGGATTacaaaatcgttatcattttgatttaa a" /listShort="adcA, adcC, adcB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 289825..289844 /Source="Nicolas_upshift_promotors" /id="U208" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.401598401598402" /psig="0.999000999001" /xcortree=669 /SigmaFactorBS="ggcgggaagaataaatgaaaatgaaatttatTCTTGCAAaac gtaatgacttcgGTTTATTATGATATAGGATTacaaaatcgttatcattttgatttaa a" /listShort="adcA, adcC, adcB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 289831 /Source="Nicolas_upshifts" /id="U208" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.401598401598402" /psig="0.999000999001" /xcortree=669 /SigmaFactorBS="ggcgggaagaataaatgaaaatgaaatttatTCTTGCAAaac gtaatgacttcgGTTTATTATGATATAGGATTacaaaatcgttatcattttgatttaa a" /listShort="adcA, adcC, adcB" /GFF_Attribute="listLong" /label="upshifts" CDS 289899..290858 /gene="znuA" /locus_tag="BSU_02850" /old_locus_tag="BSU02850" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9379902, 12426338, 14730579, 21813502; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="Zn(II)-binding lipoprotein" /protein_id="NP_388167.1" /db_xref="EnsemblGenomes-Gn:BSU02850" /db_xref="EnsemblGenomes-Tr:CAB12079" /db_xref="GOA:O34966" /db_xref="InterPro:IPR006127" /db_xref="InterPro:IPR006128" /db_xref="InterPro:IPR006129" /db_xref="PDB:2O1E" /db_xref="SubtiList:BG12763" /db_xref="UniProtKB/Swiss-Prot:O34966" /translation="MFKKWSGLFVIAACFLLVAACGNSSTKGSADSKGDKLHVVTTFY PMYEFTKQIVKDKGDVDLLIPSSVEPHDWEPTPKDIANIQDADLFVYNSEYMETWVPS AEKSMGQGHAVFVNASKGIDLMEGSEEEHEEHDHGEHEHSHAMDPHVWLSPVLAQKEV KNITAQIVKQDPDNKEYYEKNSKEYIAKLQDLDKLYRTTAKKAEKKEFITQHTAFGYL AKEYGLKQVPIAGLSPDQEPSAASLAKLKTYAKEHNVKVIYFEEIASSKVADTLASEI GAKTEVLNTLEGLSKEEQDKGLGYIDIMKQNLDALKDSLLVKS*" /label="znuA CDS" gene 289899..290858 /gene="znuA" /locus_tag="BSU_02850" /old_locus_tag="BSU02850" /label="znuA gene" promotor_-35 290454..290460 /Source="Nicolas_upshift_promotors" /id="U209" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.461538461538462" /psig="0.998001998001998" /xcortree=670 /SigmaFactorBS="aacaaagaatactatgagaaaaatagtaaagaatatATTGCA AaactgcaggatctTGATAAACTATATCGTACAAccgcaaaaaaagcggagaaaaaag a" /listShort="adcC, adcB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 290474..290493 /Source="Nicolas_upshift_promotors" /id="U209" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.461538461538462" /psig="0.998001998001998" /xcortree=670 /SigmaFactorBS="aacaaagaatactatgagaaaaatagtaaagaatatATTGCA AaactgcaggatctTGATAAACTATATCGTACAAccgcaaaaaaagcggagaaaaaag a" /listShort="adcC, adcB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 290478 /Source="Nicolas_upshifts" /id="U209" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.461538461538462" /psig="0.998001998001998" /xcortree=670 /SigmaFactorBS="aacaaagaatactatgagaaaaatagtaaagaatatATTGCA AaactgcaggatctTGATAAACTATATCGTACAAccgcaaaaaaagcggagaaaaaag a" /listShort="adcC, adcB" /GFF_Attribute="listLong" /label="upshifts" downshifts 290830 /Source="Nicolas_upshifts" /id="D119" /incds=0 /nref=140 /ntot=250 /MaxReadThrough="6.07181" /MaxDrop="5.15011" /score="8.99106569" /energy="-15.9" /TU="U206,U208,U209" /idTUdmin="U206" /TUdmin="-1562" /isTUend="FALSE" /label="downshifts" CDS 290914..291609 /gene="znuC" /locus_tag="BSU_02860" /old_locus_tag="BSU02860" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9379902, 9811636, 21813502" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9379902, 9811636, 21813502; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Zn(II) transporter (ATP-binding protein)" /protein_id="NP_388168.1" /db_xref="EnsemblGenomes-Gn:BSU02860" /db_xref="EnsemblGenomes-Tr:CAB12080" /db_xref="GOA:O34946" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12764" /db_xref="UniProtKB/Swiss-Prot:O34946" /translation="MNLVSLKDIVFGYSHTPVLDKVSLDIESGEFVGITGPNGASKST LIKVMLGMLKPWEGTVTISKRNTEGKRLTIGYVPQQISSFNAGFPSTVLELVQSGRYT KGKWFKRLNEEDHLEVEKALKMVEMWDLRHRKIGDLSGGQKQKICIARMLASNPDLLM LDEPTTAVDYDSRKGFYEFMHHLVKNHNRTVVMVTHEQNEVQQFLDKVIRLERGEKGG WKCLTWNSCDELF*" /label="znuC CDS" gene 290914..291609 /gene="znuC" /locus_tag="BSU_02860" /old_locus_tag="BSU02860" /label="znuC gene" CDS 291567..292409 /gene="znuB" /locus_tag="BSU_02870" /old_locus_tag="BSU02870" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 9379902, 9811636, 21813502" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 9379902, 9811636, 21813502; Product type t: transporter" /codon_start=1 /transl_table=11 /product="high affinity Zn(II) ABC transporter (permease)" /protein_id="NP_388169.1" /db_xref="EnsemblGenomes-Gn:BSU02870" /db_xref="EnsemblGenomes-Tr:CAB12081" /db_xref="GOA:O34610" /db_xref="InterPro:IPR001626" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12765" /db_xref="UniProtKB/Swiss-Prot:O34610" /translation="MEMFDLEFMRRAFLAGGMIAVMAPILGVYLVLRRQALMADTLSH ISLSGVAIGFFLSTNITAASIVVVTIGAIGIEYMRRAYRTYSEVSIAILMAAGLSFAM FLISLSKGTANMSIDQYLFGSLVTVNQQQVYIISIITLLILLYFIVLRRPLYLLTFDE ATAKTSGINTNVLSLSFSIVTGLAISVIIPIIGVLLVSALLVLPAAFAIRIAKGFNMV FITAILISLFSVFTGLTSSYQLGTPPGPSITLLLIVLLLIGFAVQGVWTFIKKEAQRK KRSR*" /label="znuB CDS" gene 291567..292409 /gene="znuB" /locus_tag="BSU_02870" /old_locus_tag="BSU02870" /label="znuB gene" downshifts 292396 /Source="Nicolas_upshifts" /id="D120" /incds=0 /nref=168 /ntot=266 /MaxReadThrough="2.4865" /MaxDrop="6.44929" /score="27.8218406" /energy="-13.6" /TU="NA" /idTUdmin="U206" /TUdmin=4 /isTUend="TRUE" /label="downshifts" CDS complement(292447..293442) /gene="yceB" /locus_tag="BSU_02880" /old_locus_tag="BSU02880" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16428414; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative luciferase-like monooxygenase" /protein_id="NP_388170.2" /db_xref="EnsemblGenomes-Gn:BSU02880" /db_xref="EnsemblGenomes-Tr:CAB12082" /db_xref="GOA:O34504" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR019949" /db_xref="InterPro:IPR036661" /db_xref="SubtiList:BG12766" /db_xref="UniProtKB/Swiss-Prot:O34504" /translation="MIHLSILDQAPVSKGESPVTTLQHSVELAQLSEQWGYKRYWFAE HHSTKGLASTAPEIMIARIAAQTNTIRVGSGGVLLPQYSPFKVAETFRQLEALYPNRI DLGVGRSPGGTTKTRLALTDGVKKSLTEFNRQLQDVSYFLTDSLPPDHPYAGIKAAPL IGTAPELWVLGLGENSARRAAHQGIGYVFGHFINPERGENAFRIYRESFRPSAHFSNP SALFTIFVICAKTDEEAEELALSQDLWLLRVGKGLDSRVPSIEEAKAHPYTASDKKLI EENRKRMVIGSPTTVKQQLLDLTGCYETNEIMVLCNVFDFEAKKESYERLAELFL*" /label="yceB CDS" gene complement(292447..293442) /gene="yceB" /locus_tag="BSU_02880" /old_locus_tag="BSU02880" /label="yceB gene" promotor_-35 293398..293405 /Source="Nicolas_upshift_promotors" /id="U210" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig="0.997002997002997" /xcortree=1949 /SigmaFactorBS="accgaatgctggagagttgtcacagggctttcTCCTTTAGaa acaggtgcctgaTCAAGTATGCTTAAATGAATcaaaaggccgcttcctttctgtctgt t" /listShort="S105" /listLong="S106, yceC, yceD, yceE, yceF, yceG, yceH" /label="promotor_-35" promotor_-10 293420..293439 /Source="Nicolas_upshift_promotors" /id="U210" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig="0.997002997002997" /xcortree=1949 /SigmaFactorBS="accgaatgctggagagttgtcacagggctttcTCCTTTAGaa acaggtgcctgaTCAAGTATGCTTAAATGAATcaaaaggccgcttcctttctgtctgt t" /listShort="S105" /listLong="S106, yceC, yceD, yceE, yceF, yceG, yceH" /label="promotor_-10" S_feature 293426..293628 /Source="Nicolas_S_feature" /locus_tag="new_311859_312061" /HighExp="Diami, Etha, dia5, Salt, H2O2, dia15, Paraq, T-0.40H, T0.30H, G135" /AntisenseName="yceB" /AntisenseCor="0.84300534435872998" /AntisenseRegPval="-73.099999999999994" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S105" upshifts 293426 /Source="Nicolas_upshifts" /id="U210" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig="0.997002997002997" /xcortree=1949 /SigmaFactorBS="accgaatgctggagagttgtcacagggctttcTCCTTTAGaa acaggtgcctgaTCAAGTATGCTTAAATGAATcaaaaggccgcttcctttctgtctgt t" /listShort="S105" /listLong="S106, yceC, yceD, yceE, yceF, yceG, yceH" /label="upshifts" promotor_-10 complement(293474..293493) /Source="Nicolas_upshift_promotors" /id="U211" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig="0.992007992007992" /xcortree=1952 /SigmaFactorBS="gctataaagtgcgcttcttaaacaaacCATTTGACgcgggca agtcattTTGCCTATTCTGGTGTCACCatctaaaaacagacagaaaggaagcggcctt t" /listShort="yceB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(293482) /Source="Nicolas_upshifts" /id="U211" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig="0.992007992007992" /xcortree=1952 /SigmaFactorBS="gctataaagtgcgcttcttaaacaaacCATTTGACgcgggca agtcattTTGCCTATTCTGGTGTCACCatctaaaaacagacagaaaggaagcggcctt t" /listShort="yceB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(293508..293515) /Source="Nicolas_upshift_promotors" /id="U211" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig="0.992007992007992" /xcortree=1952 /SigmaFactorBS="gctataaagtgcgcttcttaaacaaacCATTTGACgcgggca agtcattTTGCCTATTCTGGTGTCACCatctaaaaacagacagaaaggaagcggcctt t" /listShort="yceB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 293612..293621 /Source="Nicolas_upshift_promotors" /id="U212" /multdbtbs="SigA,SigW" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1676 /SigmaFactorBS="agttttttttcgaggtttttcgtcaattattcttaactttta CGAAACTTTGatataataacaaACGTATATATTAGTAAtttacggcttattttccttg t" /listShort="S106, yceC, yceD, yceE, yceF, yceG, yceH, yceI" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 293630..293725 /Source="Nicolas_S_feature" /locus_tag="new_312063_312158" /HighExp="T0.0H, T-0.40H, T-1.10H, T0.30H, Salt, T1.0H, Etha, T-1.40H, T1.30H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.999" /TUlongSig="SigA" /TUlongPSig="0.997" /label="S106" upshifts 293630 /Source="Nicolas_upshifts" /id="U212" /multdbtbs="SigA,SigW" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1676 /SigmaFactorBS="agttttttttcgaggtttttcgtcaattattcttaactttta CGAAACTTTGatataataacaaACGTATATATTAGTAAtttacggcttattttccttg t" /listShort="S106, yceC, yceD, yceE, yceF, yceG, yceH, yceI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 293634..293649 /Source="Nicolas_upshift_promotors" /id="U212" /multdbtbs="SigA,SigW" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1676 /SigmaFactorBS="agttttttttcgaggtttttcgtcaattattcttaactttta CGAAACTTTGatataataacaaACGTATATATTAGTAAtttacggcttattttccttg t" /listShort="S106, yceC, yceD, yceE, yceF, yceG, yceH, yceI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 293726..294325 /gene="yceC" /locus_tag="BSU_02890" /old_locus_tag="BSU02890" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 24366250; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative stress adaptation protein (tellurite resistance)" /protein_id="NP_388171.1" /db_xref="EnsemblGenomes-Gn:BSU02890" /db_xref="EnsemblGenomes-Tr:CAB12083" /db_xref="GOA:P81100" /db_xref="InterPro:IPR003325" /db_xref="SubtiList:BG12767" /db_xref="UniProtKB/Swiss-Prot:P81100" /translation="MAISLEKGQRIDLTKGKAGLSKLMVGLGWDPVSSGGGFFSKLLG GGGPNIDCDASVLMLENGKFTDKKNLIYFGNLKSRCGGVQHTGDNLTGDGAGDDEQIM IDLDKVPGNIDKLVFVVNIYDCVRRKQDFGMIQNAFIRVVDQSNHEEMLKYNLRDNYA GRTSLITAEIYRSGSEWKFAAVGEGTNDTRLEDIISRYV*" /label="yceC CDS" gene 293726..294325 /gene="yceC" /locus_tag="BSU_02890" /old_locus_tag="BSU02890" /label="yceC gene" CDS 294347..294928 /gene="yceD" /locus_tag="BSU_02900" /old_locus_tag="BSU02900" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735, 24366250; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative stress adaptation protein (tellurite resistance)" /protein_id="NP_388172.1" /db_xref="EnsemblGenomes-Gn:BSU02900" /db_xref="EnsemblGenomes-Tr:CAB12084" /db_xref="GOA:P80875" /db_xref="InterPro:IPR003325" /db_xref="SubtiList:BG12768" /db_xref="UniProtKB/Swiss-Prot:P80875" /translation="MTISLAKGQKVDLTKTNPGLSKVVVGLGWDTNKYDGGHDFDLDS SVFLLDAAGKCASPNDFIFYNQLEGGNGSVVHSGDNLTGAGEGDDENVKVNLSAVPAN IDKISFVITIHDAEARSQNFGQVSNAFVRIVNEETNEELIRYDLAEDFSIETAIIAGE LYRHNGEWKFSAIGSGYQGGLARIATDYGLQVG*" /label="yceD CDS" gene 294347..294928 /gene="yceD" /locus_tag="BSU_02900" /old_locus_tag="BSU02900" /label="yceD gene" CDS 294963..295541 /gene="yceE" /locus_tag="BSU_02910" /old_locus_tag="BSU02910" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735, 24366250, 25355936; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative stress adaptation protein (tellurite resistance)" /protein_id="NP_388173.1" /db_xref="EnsemblGenomes-Gn:BSU02910" /db_xref="EnsemblGenomes-Tr:CAB12085" /db_xref="GOA:O34384" /db_xref="InterPro:IPR003325" /db_xref="SubtiList:BG12769" /db_xref="UniProtKB/Swiss-Prot:O34384" /translation="MAIQLSKGQRIDLTKTNPGLTKAVIGLGWDTNKYSGGHDFDLDA SAFLVDAHDNCVNDLDFVFYNNLEHPSGGVIHTGDNRTGEGDGDDEQIIVDFSKIPAH IEKIGITVTIHDAEARSQNFGQVSNAFVRVVDEETQNELLRFDLGEDFSIETAVVVCE LYRHGGEWKFNAIGSGFSGGLAALCRNYGLQV*" /label="yceE CDS" gene 294963..295541 /gene="yceE" /locus_tag="BSU_02910" /old_locus_tag="BSU02910" /label="yceE gene" CDS 295592..296365 /gene="yceF" /locus_tag="BSU_02920" /old_locus_tag="BSU02920" /function="16.8: Protect" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735, 24366250; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative stress adaptation transporter (tellurite resistance)" /protein_id="NP_388174.1" /db_xref="EnsemblGenomes-Gn:BSU02920" /db_xref="EnsemblGenomes-Tr:CAB12086" /db_xref="GOA:O34447" /db_xref="InterPro:IPR005496" /db_xref="InterPro:IPR022493" /db_xref="SubtiList:BG12770" /db_xref="UniProtKB/Swiss-Prot:O34447" /translation="MDFLHHILSTYASFFDWKMWGEVLTDPVSWGLIGSLVVLEGLLS ADNALVLAVMVKHLPEKQRKKALTYGLFGAYIFRFIFIGLGMLLIKFWWIKVLGALYL AWLVIKHFWIGEKEEEADGMKKNSWMVRTFGIFWATVISVELMDLAFSVDSILAAFAV SEKVWVLLIGGMLGILMMRTVAKVFLVLIDKIPELENTAFVLIGIIALKMAGSAFHYE MPHSVFFIIIIAAFAVTLIIHYINKQKQVREQTAASKEE*" /label="yceF CDS" gene 295592..296365 /gene="yceF" /locus_tag="BSU_02920" /old_locus_tag="BSU02920" /label="yceF gene" downshifts 296352 /Source="Nicolas_upshifts" /id="D121" /incds=0 /nref=46 /ntot=239 /MaxReadThrough="6.82513" /MaxDrop="4.0674" /score="4.0495978" /energy="-8.2" /TU="U212" /idTUdmin="U210" /TUdmin=2728 /isTUend="FALSE" /label="downshifts" CDS 296450..298063 /gene="yceG" /locus_tag="BSU_02930" /old_locus_tag="BSU02930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 24366250; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative toxic compound adaptation protein (tellurite resistance)" /protein_id="NP_388175.1" /db_xref="EnsemblGenomes-Gn:BSU02930" /db_xref="EnsemblGenomes-Tr:CAB12087" /db_xref="InterPro:IPR025647" /db_xref="SubtiList:BG12771" /db_xref="UniProtKB/Swiss-Prot:O34809" /translation="MRQEELTIHKALPADGDWKSLLFQPLPERDHYETAQGLSFSRLA GQILGTPIDETDYYNELYELSVNDRITILSETLDKTIEPETFQKLQHIHSINQKEKGL SVSRFVAFLDGEKLIAKHSNPLMHRHLRKALMTLLHTFADSHEKGLNHPDFRRVLLDV SKFSLNHLNPWLEKTDIEREMPKVVWYGDATKSQLYFLYYLMLVGCDVLLFHPAGTDQ LALVDPKQELGFTEKLPDVSELQPFPKEKPDRKSTVAYRSTKEIEHVLNHEESMLYKP WQFRDHTPVSVTLKTTYDELFLITKERAFIRPNFKADKHSIEIPNVFAKIMGVSKDNK EYWNRLHTLADYQETEMVRSFPFTEEIKSNYQFHYSHALDQEGNIDPDKLMASNVWQY KQLPAGVQTAIAKTISRMCRYPRLKALHQEQVKDVQIYLFKQTTNLPANLLKLIQMFD YAQTVPKLVLYHTEMSGGLTRSDAAALLFLNEIGIDIIIYNPPGHQDIEQFIEEDQYD IHWLDDMVFQQDYKEPSLVKRLFRTITQK*" /label="yceG CDS" gene 296450..298063 /gene="yceG" /locus_tag="BSU_02930" /old_locus_tag="BSU02930" /label="yceG gene" CDS 298079..299170 /gene="yceH" /locus_tag="BSU_02940" /old_locus_tag="BSU02940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735, 24366250; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative reactive oxygen species resistance protein" /protein_id="NP_388176.1" /db_xref="EnsemblGenomes-Gn:BSU02940" /db_xref="EnsemblGenomes-Tr:CAB12088" /db_xref="InterPro:IPR008863" /db_xref="SubtiList:BG12772" /db_xref="UniProtKB/Swiss-Prot:O34833" /translation="MTTENQNPLVLDKNEEISQQKADDIRLQLRQEPEVKRLAQQIDV KNQMELLEYGKEPAVEISKFSDRILGMMKTTSVTDSGTMLTQLGKIMDRFDKNDFDEP KGLMAKIFKRGGSMIEKIFKKYQTLGGEIEKIHVEISKYKDEMTKTNYTLDEMYENNI KYYMELEKYVVAGQMKLEEMQSILPSYEEKAASGNQLAQMQLDTLRNGIQALEERVYD LDMARMVALQTAPQIRLLQRGNAKLIGKINSAFIITIPIFKNGIIQAVTVKRQKLVAD SMSELDRRTNEMLKRNAENISSQSVEIARMAGRPSIDIETIESSWNTIVSGMQETKQI EEENKRLREDGARRIAQLQDNIKKAALQQ*" /label="yceH CDS" gene 298079..299170 /gene="yceH" /locus_tag="BSU_02940" /old_locus_tag="BSU02940" /label="yceH gene" downshifts 299144 /Source="Nicolas_upshifts" /id="D122" /incds=0 /nref=85 /ntot=228 /MaxReadThrough="4.46836" /MaxDrop="4.05585" /score="-6.59172775" /energy="-17.5" /TU="U212" /idTUdmin="U212" /TUdmin="-1322" /isTUend="FALSE" /label="downshifts" promotor_-35 299224..299231 /Source="Nicolas_upshift_promotors" /id="U213" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig="0.998001998001998" /xcortree=2427 /SigmaFactorBS="aagcggggtatttcaattacatcatttagtTAATGACAatgt gtaaagacagGTGTAAACTTAAACGGTAATcattttgcatatcagaggtgttggcaat g" /listShort="yceI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 299246..299265 /Source="Nicolas_upshift_promotors" /id="U213" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig="0.998001998001998" /xcortree=2427 /SigmaFactorBS="aagcggggtatttcaattacatcatttagtTAATGACAatgt gtaaagacagGTGTAAACTTAAACGGTAATcattttgcatatcagaggtgttggcaat g" /listShort="yceI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 299254 /Source="Nicolas_upshifts" /id="U213" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig="0.998001998001998" /xcortree=2427 /SigmaFactorBS="aagcggggtatttcaattacatcatttagtTAATGACAatgt gtaaagacagGTGTAAACTTAAACGGTAATcattttgcatatcagaggtgttggcaat g" /listShort="yceI" /GFF_Attribute="listLong" /label="upshifts" CDS 299292..300494 /gene="niaP" /locus_tag="BSU_02950" /old_locus_tag="BSU02950" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 18276644, 21953179" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 18276644, 21953179; Product type t: transporter" /codon_start=1 /transl_table=11 /product="niacin permease" /protein_id="NP_388177.1" /db_xref="EnsemblGenomes-Gn:BSU02950" /db_xref="EnsemblGenomes-Tr:CAB12089" /db_xref="GOA:O34691" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12773" /db_xref="UniProtKB/Swiss-Prot:O34691" /translation="MGKQQPISQRKLLGVAGLGWLFDAMDVGILSFIIAALHVEWNLS PEEMKWIGSVNSIGMAAGAFLFGLLADRIGRKKVFIITLLCFSIGSGISAFVTSLSAF LILRFVIGMGLGGELPVASTLVSEAVVPEKRGRVIVLLESFWAVGWLAAALISYFVIP SFGWQAALLLTALTAFYALYLRTSLPDSPKYESLSAKKRSMWENVKSVWARQYIRPTV MLSIVWFCVVFSYYGMFLWLPSVMLLKGFSMIQSFEYVLLMTLAQLPGYFSAAWLIEK AGRKWILVVYLIGTAGSAYFFGTADSLSLLLTAGVLLSFFNLGAWGVLYAYTPEQYPT AIRATGSGTTAAFGRIGGIFGPLLVGTLAARHISFSVIFSIFCIAILLAVACILIMGK ETKQTELE*" /label="niaP CDS" gene 299292..300494 /gene="niaP" /locus_tag="BSU_02950" /old_locus_tag="BSU02950" /label="niaP gene" downshifts 300474 /Source="Nicolas_upshifts" /id="D123" /incds=0 /nref=8 /ntot=184 /MaxReadThrough="4.1968" /MaxDrop="3.48367" /score="13.0427769" /energy="-10.6" /TU="U213" /idTUdmin="U212" /TUdmin=8 /isTUend="TRUE" /label="downshifts" CDS complement(300747..301919) /gene="yceJ" /locus_tag="BSU_02960" /old_locus_tag="BSU02960" /function="16.8: Protect" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative carbohydrate transporter (possibly exporter)" /protein_id="NP_388178.1" /db_xref="EnsemblGenomes-Gn:BSU02960" /db_xref="EnsemblGenomes-Tr:CAB12090" /db_xref="GOA:O34724" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12774" /db_xref="UniProtKB/Swiss-Prot:O34724" /translation="MNRIWLFFSVMFVIGTDTFLLSPLLPLLQDQFHVSTDLSGWMVS AYALGYALFAFIAGPISDRLNRKTVMLWGLAGFIVSTFLCGIAPSFAAMCLFRFAAGV SAAFVTPQIWASIPVIVQPSQIIKGMGIATAGLAASQMLGLPIGGFLASFTWHTPFFV LSACSLILLLILAAVMPGIRPSEPLARPSIVNPYRELFSLPKTSVILLAYFLFQTGNF ASFSFLGTWLSADYHLTVSQIGAAMLVLGLGNMLGSLIGSRVSEKLGMFKTLISGMLL MGALYFALPFFPNLFLVEAGFFLTFFTAGIIFPLMMGVFQSIAPNARGTIASLSNAAM YAGTTVGTSIAGFLYQSTQHFGAVTGFTAILFILSMTLYQTISKTGKRQSTARAQL*" /label="yceJ CDS" gene complement(300747..301919) /gene="yceJ" /locus_tag="BSU_02960" /old_locus_tag="BSU02960" /label="yceJ gene" downshifts complement(300762) /Source="Nicolas_upshifts" /id="D124" /incds=0 /nref=1 /ntot=7 /MaxReadThrough="2.6211" /MaxDrop="2.7452" /score="9.21991741" /energy="-12.6" /TU="NA" /idTUdmin="U214" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(301988..302290) /gene="yceK" /locus_tag="BSU_02970" /old_locus_tag="BSU02970" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (ArsR family)" /protein_id="NP_388179.1" /db_xref="EnsemblGenomes-Gn:BSU02970" /db_xref="EnsemblGenomes-Tr:CAB12091" /db_xref="GOA:O34464" /db_xref="InterPro:IPR001845" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12775" /db_xref="UniProtKB/Swiss-Prot:O34464" /translation="MYYSFMTMKQSDDQIRAQIFKALSDESRLAIIRTLYVSGKELSC GEVGEKCNIVKTTASYHFKTLREAGLTATRKDSRTKYVSLREDTFQTYLPGFLETL*" /label="yceK CDS" gene complement(301988..302290) /gene="yceK" /locus_tag="BSU_02970" /old_locus_tag="BSU02970" /label="yceK gene" downshifts complement(302016) /Source="Nicolas_upshifts" /id="D125" /incds=0 /nref=221 /ntot=261 /MaxReadThrough="5.67096" /MaxDrop="6.89889" /score="2.01231069" /energy="-4.8" /TU="U214" /idTUdmin="U214" /TUdmin="-1254" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(302273..302292) /Source="Nicolas_upshift_promotors" /id="U214" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.455544455544456" /psig="0.999000999001" /xcortree=635 /SigmaFactorBS="ccttcctcttatgacttcctgctcctttactggaaaaataAG TTGCTttttcaacacccaTTATGTATTATAGTTTCATGactatgaaacaatcagatga t" /listShort="yceK, yceJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(302292) /Source="Nicolas_upshifts" /id="U214" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.455544455544456" /psig="0.999000999001" /xcortree=635 /SigmaFactorBS="ccttcctcttatgacttcctgctcctttactggaaaaataAG TTGCTttttcaacacccaTTATGTATTATAGTTTCATGactatgaaacaatcagatga t" /listShort="yceK, yceJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(302306..302312) /Source="Nicolas_upshift_promotors" /id="U214" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.455544455544456" /psig="0.999000999001" /xcortree=635 /SigmaFactorBS="ccttcctcttatgacttcctgctcctttactggaaaaataAG TTGCTttttcaacacccaTTATGTATTATAGTTTCATGactatgaaacaatcagatga t" /listShort="yceK, yceJ" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 302539..302558 /Source="Nicolas_upshift_promotors" /id="U215" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.555444555444555" /psig="0.99100899100899" /xcortree=2422 /SigmaFactorBS="gtttataaagaaatggtacagaataaaagagaatatgctgtt tgtgtgggaagttacataAATGTTACGGTAATAAAGATtgcttaatatggagggaaaa t" /listShort="opuAA, opuAB, opuAC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 302539 /Source="Nicolas_upshifts" /id="U215" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.555444555444555" /psig="0.99100899100899" /xcortree=2422 /SigmaFactorBS="gtttataaagaaatggtacagaataaaagagaatatgctgtt tgtgtgggaagttacataAATGTTACGGTAATAAAGATtgcttaatatggagggaaaa t" /listShort="opuAA, opuAB, opuAC" /GFF_Attribute="listLong" /label="upshifts" CDS 302580..303836 /gene="opuAA" /locus_tag="BSU_02980" /old_locus_tag="BSU02980" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7622480, 16225868, 16645306, 25012968" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7622480, 16225868, 16645306, 25012968; Product type t: transporter" /codon_start=1 /transl_table=11 /product="L-proline betaine and betonicine ABC transporter(ATP-binding protein)" /protein_id="NP_388180.2" /db_xref="EnsemblGenomes-Gn:BSU02980" /db_xref="EnsemblGenomes-Tr:CAB12092" /db_xref="GOA:P46920" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005892" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11370" /db_xref="UniProtKB/Swiss-Prot:P46920" /translation="MSVDEKPIKIKVEKVSKIFGKQTKKAVQMLANGKTKKEILKATG STVGVNQADFEVYDGEIFVIMGLSGSGKSTLVRMLNRLIEPTAGNIYIDGDMITNMSK DQLREVRRKKISMVFQKFALFPHRTILENTEYGLELQGVDKQERQQKALESLKLVGLE GFEHQYPDQLSGGMQQRVGLARALTNDPDILLMDEAFSALDPLIRKDMQDELLDLHDN VGKTIIFITHDLDEALRIGDRIVLMKDGNIVQIGTPEEILMNPSNEYVEKFVEDVDLS KVLTAGHIMKRAETVRIDKGPRVALTLMKNLGISSIYAVDKQKKLLGVIYASDAKKAA ESDLSLQDILNTEFTTVPENTYLTEIFDVVSDANIPIAVVDEKQRMKGIVVRGALIGA LAGNNEYINAEGTNEQTQDPSAQEVK*" /label="opuAA CDS" gene 302580..303836 /gene="opuAA" /locus_tag="BSU_02980" /old_locus_tag="BSU02980" /label="opuAA gene" downshifts complement(302588) /Source="Nicolas_upshifts" /id="D126" /incds=0 /nref=108 /ntot=175 /MaxReadThrough="2.83797" /MaxDrop="5.18503" /score="2.01231069" /energy="-4.8" /TU="NA" /idTUdmin="U214" /TUdmin="-1826" /isTUend="FALSE" /label="downshifts" CDS 303838..304686 /gene="opuAB" /locus_tag="BSU_02990" /old_locus_tag="BSU02990" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8752321, 15849754, 16225868, 16645306, 16850406, 25012968" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8752321, 15849754, 16225868, 16645306, 16850406, 25012968; Product type t : transporter" /codon_start=1 /transl_table=11 /product="L-proline betaine and betonicine ABC transporter(permease)" /protein_id="NP_388181.1" /db_xref="EnsemblGenomes-Gn:BSU02990" /db_xref="EnsemblGenomes-Tr:CAB12093" /db_xref="GOA:P46921" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11371" /db_xref="UniProtKB/Swiss-Prot:P46921" /translation="MDRLPRIPLADIIDRFVDWITMTFGGFFDGIANGLAAFVNGIVT GLGFIPSILLTIIFAALAWWISTRGIALFTLIGFLLIDYLGYWDPMLQTLALVLTSVI ISIVVGVPIGIWASQKETVRRIVTPILDLMQTMPAFVYLLPAIFFFNIGVVPGVVASV IFAMPPTIRMTVLGIKQVPADLIEATEAFGSTTAQRLFKVQLPLATKTILAGINQSIM LALSMVVIAAMVGAPGLGSEVYSAVTQLKTGVGVEAGIAIVIVAITLDRITQNIKVKK KSRGNA*" /label="opuAB CDS" gene 303838..304686 /gene="opuAB" /locus_tag="BSU_02990" /old_locus_tag="BSU02990" /label="opuAB gene" CDS 304686..305567 /gene="opuAC" /locus_tag="BSU_03000" /old_locus_tag="BSU03000" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7622480, 16225868, 16645306, 25012968" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7622480, 16225868, 16645306, 25012968; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="L-proline betaine and betonicine ABC transporterABC transporter (glycine betaine-binding lipoprotein)" /protein_id="NP_388182.1" /db_xref="EnsemblGenomes-Gn:BSU03000" /db_xref="EnsemblGenomes-Tr:CAB12094" /db_xref="GOA:P46922" /db_xref="InterPro:IPR007210" /db_xref="PDB:2B4L" /db_xref="PDB:2B4M" /db_xref="PDB:3CHG" /db_xref="SubtiList:BG11372" /db_xref="UniProtKB/Swiss-Prot:P46922" /translation="MLKKIIGIGVSAMLALSLAACGSENDENASAAEQVNKTIIGIDP GSGIMSLTDKAMKDYDLNDWTLISASSAAMTATLKKSYDRKKPIIITGWTPHWMFSRY KLKYLDDPKQSYGSAEEIHTITRKGFSKEQPNAAKLLSQFKWTQDEMGEIMIKVEEGE KPAKVAAEYVNKHKDQIAEWTKGVQKVKGDKINLAYVAWDSEIASTNVIGKVLEDLGY EVTLTQVEAGPMWTAIATGSADASLSAWLPNTHKAYAAKYKGKYDDIGTSMTGVKMGL VVPQYMKNVNSIEDLKK*" /label="opuAC CDS" gene 304686..305567 /gene="opuAC" /locus_tag="BSU_03000" /old_locus_tag="BSU03000" /label="opuAC gene" downshifts 305548 /Source="Nicolas_upshifts" /id="D127" /incds=0 /nref=254 /ntot=269 /MaxReadThrough="0.74967" /MaxDrop="8.21394" /score="33.6263027" /energy="-12.2" /TU="NA" /idTUdmin="U215" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(305580) /Source="Nicolas_upshifts" /id="D128" /incds=0 /nref=2 /ntot=62 /MaxReadThrough="4.29566" /MaxDrop="3.9514" /score="29.8489328" /energy="-12.2" /TU="U216" /idTUdmin="U216" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" CDS complement(305605..306756) /gene="amhX" /locus_tag="BSU_03010" /old_locus_tag="BSU03010" /EC_number="3.5.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8768514; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative amidohydrolase" /protein_id="NP_388183.2" /db_xref="EnsemblGenomes-Gn:BSU03010" /db_xref="EnsemblGenomes-Tr:CAB12095" /db_xref="GOA:P54983" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR017439" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG11789" /db_xref="UniProtKB/Swiss-Prot:P54983" /translation="MQKLSEEMKQTIMDIFEHLHANPEVSWKEYETTSFLKQKLEDLG CRTRTFSDCTGVVGEIGSGSPVVAVRADIDALWQEVNGTFRANHSCGHDSHMTMALGT LMLLKKQPELPKGTIRFIFQPAEEKGGGALKMIEEGVLDDIDYLYGVHVRPIQETQNG RCAPSILHGSSQHIEGTIIGEEAHGARPHLGKNSIEIAAFLVHKLGLIHIDPQIPHTV KMTKLQAGGESSNIIPGKASFSLDLRAQTNEAMEALIAETERACEAAAAAFGAKIELH KEHSLPAATQNKEAEAIMAEAITEIIGAERLDDPLVTTGGEDFHFYAVKVPNLKTTML GLGCGLQPGLHHPHMTFDRNAMFTGIHILANAVLKTFQKAESLAAANAS*" /label="amhX CDS" gene complement(305605..306756) /gene="amhX" /locus_tag="BSU_03010" /old_locus_tag="BSU03010" /label="amhX gene" downshifts complement(305624) /Source="Nicolas_upshifts" /id="D129" /incds=0 /nref=2 /ntot=70 /MaxReadThrough="4.33606" /MaxDrop="3.5225" /score="29.8489328" /energy="-12.2" /TU="U216" /idTUdmin="U216" /TUdmin="-264" /isTUend="FALSE" /label="downshifts" S_feature complement(306757..306844) /Source="Nicolas_S_feature" /locus_tag="new_325190_325277_c" /HighExp="Etha, T1.30H, M9-stat, T2.30H, S1, T3.30H, T5.0H, T4.0H, Sw, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S107" promotor_-35 306812..306819 /Source="Nicolas_upshift_promotors" /id="U217" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.758241758241758" /psig="0.999000999001" /xcortree=2902 /SigmaFactorBS="atttttaccttctttactttatttaTATTGAAAcaggaagat aggctGTATATAATATAGCACATATtgctactattcagaataattaatattttcaaac a" /listShort="ycgA" /listLong="ycgB, S108, amyE" /label="promotor_-35" promotor_-10 complement(306831..306850) /Source="Nicolas_upshift_promotors" /id="U216" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.632367632367632" /psig=1 /xcortree=2878 /SigmaFactorBS="tttcgatccatcccctctgtttgaaaatattaattATTCTGA atagtagcaataTGTGCTATATTATATACAGCctatcttcctgtttcaatataaataa a" /listShort="S107, amhX" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 306834..306853 /Source="Nicolas_upshift_promotors" /id="U217" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.758241758241758" /psig="0.999000999001" /xcortree=2902 /SigmaFactorBS="atttttaccttctttactttatttaTATTGAAAcaggaagat aggctGTATATAATATAGCACATATtgctactattcagaataattaatattttcaaac a" /listShort="ycgA" /listLong="ycgB, S108, amyE" /label="promotor_-10" upshifts complement(306844) /Source="Nicolas_upshifts" /id="U216" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.632367632367632" /psig=1 /xcortree=2878 /SigmaFactorBS="tttcgatccatcccctctgtttgaaaatattaattATTCTGA atagtagcaataTGTGCTATATTATATACAGCctatcttcctgtttcaatataaataa a" /listShort="S107, amhX" /GFF_Attribute="listLong" /label="upshifts" upshifts 306847 /Source="Nicolas_upshifts" /id="U217" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.758241758241758" /psig="0.999000999001" /xcortree=2902 /SigmaFactorBS="atttttaccttctttactttatttaTATTGAAAcaggaagat aggctGTATATAATATAGCACATATtgctactattcagaataattaatattttcaaac a" /listShort="ycgA" /listLong="ycgB, S108, amyE" /label="upshifts" promotor_-35 complement(306863..306869) /Source="Nicolas_upshift_promotors" /id="U216" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.632367632367632" /psig=1 /xcortree=2878 /SigmaFactorBS="tttcgatccatcccctctgtttgaaaatattaattATTCTGA atagtagcaataTGTGCTATATTATATACAGCctatcttcctgtttcaatataaataa a" /listShort="S107, amhX" /GFF_Attribute="listLong" /label="promotor_-35" CDS 306906..308339 /gene="ycgA" /locus_tag="BSU_03020" /old_locus_tag="BSU03020" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 21747963, 21764931; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative branched chain amino acid permease" /protein_id="NP_388184.2" /db_xref="EnsemblGenomes-Gn:BSU03020" /db_xref="EnsemblGenomes-Tr:CAB12096" /db_xref="GOA:P55908" /db_xref="InterPro:IPR018385" /db_xref="SubtiList:BG11999" /db_xref="UniProtKB/Swiss-Prot:P55908" /translation="MSMPAAETQPKKKRMTFKMPDAYVLLFMIAFICAIASYIVPAGE FDRVTKGDVTTAVPGSYHSIEQSPVRLISFFTSLQDGMVGSAPIIFLILFTGGTIAIL EKTGAINGLIYNVISKFRTKQLLFICIVGALFSILGTTGIVVNSVIGFIPIGLIVARS LKWDAVAGAAVIYIGCYAGFNSTILSPSPLGLSQSIAELPLFSGIGLRVVIYICFLLS SIIYIYLYTRKLKKSKDASVLGTDWFPAAGMGEAGKEEDQSVPFTVRHKLILAVAGLS LVGFLYGALKLGWSDSQMAATFIFISVLAGLIGGLAANDIAKTFITGCQSLVYGALIV GMARSISVILENGKLLDTVVNALASLLDGFSPIAGAIGMYIASALLHFLISSGSGEAV VFIPILAPLADLMGITRQVAVEAVMLGEGVVNCVNPTSGVLMAVLAASGIPYVKWLRF MVPLALIWFLIGLVFIVIGVMINWGPF*" /label="ycgA CDS" gene 306906..308339 /gene="ycgA" /locus_tag="BSU_03020" /old_locus_tag="BSU03020" /label="ycgA gene" promotor_-35 307644..307652 /Source="Nicolas_upshift_promotors" /id="U218" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=498 /SigmaFactorBS="ggaacagattggttccctgcgGCAGGAATGggcgaagccggT AAAGAAGAAGATCAGTCAgtgccgtttaccgttcgccataagctgattttggctgtgg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 307664..307682 /Source="Nicolas_upshift_promotors" /id="U218" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=498 /SigmaFactorBS="ggaacagattggttccctgcgGCAGGAATGggcgaagccggT AAAGAAGAAGATCAGTCAgtgccgtttaccgttcgccataagctgattttggctgtgg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 307683 /Source="Nicolas_upshifts" /id="U218" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=498 /SigmaFactorBS="ggaacagattggttccctgcgGCAGGAATGggcgaagccggT AAAGAAGAAGATCAGTCAgtgccgtttaccgttcgccataagctgattttggctgtgg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 308321 /Source="Nicolas_upshifts" /id="D130" /incds=0 /nref=1 /ntot=74 /MaxReadThrough="3.53497" /MaxDrop="3.31444" /score="12.0135493" /energy="-15.6" /TU="U217" /idTUdmin="U218" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 308382..308389 /Source="Nicolas_upshift_promotors" /id="U219" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig="0.999000999001" /xcortree=1929 /SigmaFactorBS="ccggcttgtacggcgggcttttgagttatTCATTGCAgaagc gcaggctgtTATTGTAACATGTAAGCCATaagccattcgtaaaagtgcgggaggaagg t" /listShort="ycgB, S108, amyE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 308404..308423 /Source="Nicolas_upshift_promotors" /id="U219" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig="0.999000999001" /xcortree=1929 /SigmaFactorBS="ccggcttgtacggcgggcttttgagttatTCATTGCAgaagc gcaggctgtTATTGTAACATGTAAGCCATaagccattcgtaaaagtgcgggaggaagg t" /listShort="ycgB, S108, amyE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 308413 /Source="Nicolas_upshifts" /id="U219" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig="0.999000999001" /xcortree=1929 /SigmaFactorBS="ccggcttgtacggcgggcttttgagttatTCATTGCAgaagc gcaggctgtTATTGTAACATGTAAGCCATaagccattcgtaaaagtgcgggaggaagg t" /listShort="ycgB, S108, amyE" /GFF_Attribute="listLong" /label="upshifts" CDS 308455..309036 /gene="ycgB" /locus_tag="BSU_03030" /old_locus_tag="BSU03030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406, 22720735; Producttype m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein of unknown function" /protein_id="NP_388185.2" /db_xref="EnsemblGenomes-Gn:BSU03030" /db_xref="EnsemblGenomes-Tr:CAB12097" /db_xref="SubtiList:BG12000" /db_xref="UniProtKB/Swiss-Prot:P55909" /translation="MNNLRNRLSGVNGKNKRVKEKEQKIWSEIGMIAGAFALLDVIIR GIMFEFPFKEWAASLVFLFIIILYYCIRAAASGMLMPRIDTKEELQKRVKQQRIESIA VAFAVVVLTMYDRGIPHTFFAWLKMILLFIVCGGVLFLLRYVIVKLAYRRAVKEEIKK KSSFLFGKRGKRSQFRAAFFIGTLICIHSAKLF*" /label="ycgB CDS" gene 308455..309036 /gene="ycgB" /locus_tag="BSU_03030" /old_locus_tag="BSU03030" /label="ycgB gene" upshifts 308849 /Source="Nicolas_upshifts" /id="U220" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.288711288711289" /psig="0.241758241758242" /xcortree=1550 /SigmaFactorBS="tgtacgacagggggattccccatacattcttcgcttggctga aaatgattcttctttttatcgtCTGCGgcggcgttctgtttctgcttcggtatgtgat t" /listShort="S108, amyE" /GFF_Attribute="listLong" /label="upshifts" misc_feature 308853..308857 /Source="Nicolas_upshift_promotors" /id="U220" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.288711288711289" /psig="0.241758241758242" /xcortree=1550 /SigmaFactorBS="tgtacgacagggggattccccatacattcttcgcttggctga aaatgattcttctttttatcgtCTGCGgcggcgttctgtttctgcttcggtatgtgat t" /listShort="S108, amyE" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-35 309012..309019 /Source="Nicolas_upshift_promotors" /id="U221" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=365 /SigmaFactorBS="ctttttttataggaacattgatttgTATTCACTctgccaagt tgtttTGATAGAGTGATTGTGATAAttttaaatgtaagcgttaacaaaattctccagt c" /listShort="S108, amyE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 309034..309053 /Source="Nicolas_upshift_promotors" /id="U221" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=365 /SigmaFactorBS="ctttttttataggaacattgatttgTATTCACTctgccaagt tgtttTGATAGAGTGATTGTGATAAttttaaatgtaagcgttaacaaaattctccagt c" /listShort="S108, amyE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 309047..309184 /Source="Nicolas_S_feature" /locus_tag="new_327480_327617" /HighExp="BC, M0t90, M40t90, S2, M9-stat, T4.0H, Sw, T3.30H, Lbtran, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-, SigA" /TUshortPSig="0.999, 0.242, 0.999" /TUlongSig="SigA" /TUlongPSig="0.999" /label="S108" upshifts 309047 /Source="Nicolas_upshifts" /id="U221" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=365 /SigmaFactorBS="ctttttttataggaacattgatttgTATTCACTctgccaagt tgtttTGATAGAGTGATTGTGATAAttttaaatgtaagcgttaacaaaattctccagt c" /listShort="S108, amyE" /GFF_Attribute="listLong" /label="upshifts" CDS 309185..311164 /gene="amyE" /locus_tag="BSU_03040" /old_locus_tag="BSU03040" /EC_number="3.2.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:3117969, 9353930" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3117969, 9353930; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alpha-amylase" /protein_id="NP_388186.2" /db_xref="EnsemblGenomes-Gn:BSU03040" /db_xref="EnsemblGenomes-Tr:CAB12098" /db_xref="GOA:P00691" /db_xref="InterPro:IPR006046" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR031319" /db_xref="InterPro:IPR031965" /db_xref="PDB:1BAG" /db_xref="PDB:1UA7" /db_xref="SubtiList:BG10473" /db_xref="UniProtKB/Swiss-Prot:P00691" /translation="MFAKRFKTSLLPLFAGFLLLFHLVLAGPAAASAETANKSNELTA PSIKSGTILHAWNWSFNTLKHNMKDIHDAGYTAIQTSPINQVKEGNQGDKSMSNWYWL YQPTSYQIGNRYLGTEQEFKEMCAAAEEYGIKVIVDAVINHTTSDYAAISNEVKSIPN WTHGNTQIKNWSDRWDVTQNSLLGLYDWNTQNTQVQSYLKRFLDRALNDGADGFRFDA AKHIELPDDGSYGSQFWPNITNTSAEFQYGEILQDSASRDAAYANYMDVTASNYGHSI RSALKNRNLGVSNISHYASDVSADKLVTWVESHDTYANDDEESTWMSDDDIRLGWAVI ASRSGSTPLFFSRPEGGGNGVRFPGKSQIGDRGSALFEDQAITAVNRFHNVMAGQPEE LSNPNGNNQIFMNQRGSHGVVLANAGSSSVSINTATKLPDGRYDNKAGAGSFQVNDGK LTGTINARSVAVLYPDDIAKAPHVFLENYKTGVTHSFNDQLTITLRADANTTKAVYQI NNGPETAFKDGDQFTIGKGDPFGKTYTIMLKGTNSDGVTRTEKYSFVKRDPASAKTIG YQNPNHWSQVNAYIYKHDGSRVIELTGSWPGKPMTKNADGIYTLTLPADTDTTNAKVI FNNGSAQVPGQNQPGFDYVLNGLYNDSGLSGSLPH*" /label="amyE CDS" gene 309185..311164 /gene="amyE" /locus_tag="BSU_03040" /old_locus_tag="BSU03040" /label="amyE gene" downshifts 311178 /Source="Nicolas_upshifts" /id="D131" /incds=0 /nref=57 /ntot=131 /MaxReadThrough="1.64783" /MaxDrop="6.55823" /score="-8.82332571" /energy="-3.4" /TU="U221" /idTUdmin="U219" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 311244..311251 /Source="Nicolas_upshift_promotors" /id="U222" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.753246753246753" /psig=1 /xcortree=1599 /SigmaFactorBS="caatgatggtttcttttttgttcataaatcagacaaaacttt tCTCTTGCAaaagtttgtgaagTGTTGCACAATATAAATGTGaaatacttcacaaaca a" /listShort="ldh, lctP" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 311261 /Source="Nicolas_upshifts" /id="U222" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.753246753246753" /psig=1 /xcortree=1599 /SigmaFactorBS="caatgatggtttcttttttgttcataaatcagacaaaacttt tCTCTTGCAaaagtttgtgaagTGTTGCACAATATAAATGTGaaatacttcacaaaca a" /listShort="ldh, lctP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 311265..311284 /Source="Nicolas_upshift_promotors" /id="U222" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.753246753246753" /psig=1 /xcortree=1599 /SigmaFactorBS="caatgatggtttcttttttgttcataaatcagacaaaacttt tCTCTTGCAaaagtttgtgaagTGTTGCACAATATAAATGTGaaatacttcacaaaca a" /listShort="ldh, lctP" /GFF_Attribute="listLong" /label="promotor_-10" CDS 311341..312306 /gene="lctE" /locus_tag="BSU_03050" /old_locus_tag="BSU03050" /EC_number="1.1.1.27" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10809684, 16207915, 19383131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10809684, 16207915, 19383131; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-lactate dehydrogenase" /protein_id="NP_388187.2" /db_xref="EnsemblGenomes-Gn:BSU03050" /db_xref="EnsemblGenomes-Tr:CAB12099" /db_xref="GOA:P13714" /db_xref="InterPro:IPR001236" /db_xref="InterPro:IPR001557" /db_xref="InterPro:IPR011304" /db_xref="InterPro:IPR015955" /db_xref="InterPro:IPR018177" /db_xref="InterPro:IPR022383" /db_xref="InterPro:IPR036291" /db_xref="PDB:3PQD" /db_xref="PDB:3PQE" /db_xref="PDB:3PQF" /db_xref="SubtiList:BG19003" /db_xref="UniProtKB/Swiss-Prot:P13714" /translation="MMNKHVNKVALIGAGFVGSSYAFALINQGITDELVVIDVNKEKA MGDVMDLNHGKAFAPQPVKTSYGTYEDCKDADIVCICAGANQKPGETRLELVEKNLKI FKGIVSEVMASGFDGIFLVATNPVDILTYATWKFSGLPKERVIGSGTTLDSARFRFML SEYFGAAPQNVHAHIIGEHGDTELPVWSHANVGGVPVSELVEKNDAYKQEELDQIVDD VKNAAYHIIEKKGATYYGVAMSLARITKAILHNENSILTVSTYLDGQYGADDVYIGVP AVVNRGGIAGITELNLNEKEKEQFLHSAGVLKNILKPHFAEQKVN*" /label="lctE CDS" gene 311341..312306 /gene="lctE" /locus_tag="BSU_03050" /old_locus_tag="BSU03050" /label="lctE gene" CDS 312338..313963 /gene="lctP" /locus_tag="BSU_03060" /old_locus_tag="BSU03060" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10809684, 15849754, 16428414, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10809684, 15849754, 16428414, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="L-lactate permease" /protein_id="NP_388188.2" /db_xref="EnsemblGenomes-Gn:BSU03060" /db_xref="EnsemblGenomes-Tr:CAB12100" /db_xref="GOA:P55910" /db_xref="InterPro:IPR003804" /db_xref="SubtiList:BG12001" /db_xref="UniProtKB/Swiss-Prot:P55910" /translation="MWEQLYDPFGNEYVSALVALTPILFFLLALTVLKMKGILAAFLT LAVSFFVSVWAFHMPVEKAISSVLLGIGSGLWPIGYIVLMAVWLYKIAVKTGKFTIIR SSIAGISPDQRLQLLLIGFCFNAFLEGAAGFGVPIAISAALLVELGFKPLKAAALCLI ANAASGAFGAIGIPVITGAQIGDLSALELSRTLMWTLPMISFLIPFLLVFLLDRMKGI KQTWPALLVVSGGYTAVQTLTMAVLGPELANILAALFSMGGLALFLRKWQPKEIYREE GAGDAGEKKAYRAADIAKAWSPFYILTAAITIWSLPAFKALFQEGGLLYQSTLLFKMP FLHQQIMKMPPIAPSAMPLDAVFKVDLLSATGTAILAAVIVTGLFSKKFSSRDAFASL KETGKELWVPIMTICFVMGFANLANFAGLSSSIGLALAKTGDLFPFVSPVLGWIGVFI TGSVVSNNALFGHLQVVTGAQIGAGSDLLLAANTAGGVMAKLVSPQSIAIAAAAVGQT GKESKLFKRTVAYSLILLLIICIWTFILARLGV*" /label="lctP CDS" gene 312338..313963 /gene="lctP" /locus_tag="BSU_03060" /old_locus_tag="BSU03060" /label="lctP gene" downshifts 312344 /Source="Nicolas_upshifts" /id="D132" /incds=0 /nref=1 /ntot=16 /MaxReadThrough="8.56142" /MaxDrop="2.8862" /score="-8.82332571" /energy="-3.4" /TU="U222" /idTUdmin="U221" /TUdmin=1144 /isTUend="FALSE" /label="downshifts" downshifts 313950 /Source="Nicolas_upshifts" /id="D133" /incds=0 /nref=51 /ntot=118 /MaxReadThrough="2.31168" /MaxDrop="7.73065" /score="39.575264" /energy="-15.6" /TU="NA" /idTUdmin="U222" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(314008..315546) /gene="mdr" /locus_tag="BSU_03070" /old_locus_tag="BSU03070" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9023234, 15489457, 15849754, 16850406, 21690368" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9023234, 15489457, 15849754, 16850406, 21690368; Product type t : transporter" /codon_start=1 /transl_table=11 /product="multidrug-efflux transporter" /protein_id="NP_388189.2" /db_xref="EnsemblGenomes-Gn:BSU03070" /db_xref="EnsemblGenomes-Tr:CAB12101" /db_xref="GOA:P96712" /db_xref="InterPro:IPR004638" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12002" /db_xref="UniProtKB/Swiss-Prot:P96712" /translation="MDTTTAKQASTKFVVLGLLLGILMSAMDNTIVATAMGNIVADLG SFDKFAWVTASYMVAVMAGMPIYGKLSDMYGRKRFFLFGLIFFLIGSALCGIAQTMNQ LIIFRAIQGIGGGALLPIAFTIIFDLFPPEKRGKMSGMFGAVFGLSSVLGPLLGAIIT DSISWHWVFYINVPIGALSLFFIIRYYKESLEHRKQKIDWGGAITLVVSIVCLMFALE LGGKTYDWNSIQIIGLFIVFAVFFIAFFIVERKAEEPIISFWMFKNRLFATAQILAFL YGGTFIILAVFIPIFVQAVYGSSATSAGFILTPMMIGSVIGSMIGGIFQTKASFRNLM LISVIAFFIGMLLLSNMTPDTARVWLTVFMMISGFGVGFNFSLLPAASMNDLEPRFRG TANSTNSFLRSFGMTLGVTIFGTVQTNVFTNKLNDAFSGMKGSAGSGAAQNIGDPQEI FQAGTRSQIPDAILNRIIDAMSSSITYVFLLALIPIVLAAVTILFMGKARVKTTAEMT KKAN*" /label="mdr CDS" gene complement(314008..315546) /gene="mdr" /locus_tag="BSU_03070" /old_locus_tag="BSU03070" /label="mdr gene" downshifts complement(314026) /Source="Nicolas_upshifts" /id="D134" /incds=0 /nref=70 /ntot=182 /MaxReadThrough="1.04964" /MaxDrop="4.53635" /score="30.8374042" /energy="-15.6" /TU="NA" /idTUdmin="U225" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_no_box complement(314600..314700) /Source="Nicolas_upshift_promotors" /id="U223" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.495504495504495" /psig="0.002997002997003" /xcortree=1728 /SigmaFactorBS="attttagcggtatttattccgattttcgttcaggcggtctac ggcagctcggcgacaagcgcgggcttcattctgacgccgatgatgattggatcagtca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(314640) /Source="Nicolas_upshifts" /id="U223" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.495504495504495" /psig="0.002997002997003" /xcortree=1728 /SigmaFactorBS="attttagcggtatttattccgattttcgttcaggcggtctac ggcagctcggcgacaagcgcgggcttcattctgacgccgatgatgattggatcagtca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 315560..315564 /Source="Nicolas_upshift_promotors" /id="U224" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.772227772227772" /psig="0.971028971028971" /xcortree=2583 /SigmaFactorBS="ttgttgtgtccatttgttctacctccTCTTActtttctatgt aagtTCTGATATCATGATAATAGTttgattgttgaatatctcgattatcaagataaac t" /listShort="ycgE, ycgF, ycgG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 315580..315599 /Source="Nicolas_upshift_promotors" /id="U224" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.772227772227772" /psig="0.971028971028971" /xcortree=2583 /SigmaFactorBS="ttgttgtgtccatttgttctacctccTCTTActtttctatgt aagtTCTGATATCATGATAATAGTttgattgttgaatatctcgattatcaagataaac t" /listShort="ycgE, ycgF, ycgG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 315594 /Source="Nicolas_upshifts" /id="U224" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.772227772227772" /psig="0.971028971028971" /xcortree=2583 /SigmaFactorBS="ttgttgtgtccatttgttctacctccTCTTActtttctatgt aagtTCTGATATCATGATAATAGTttgattgttgaatatctcgattatcaagataaac t" /listShort="ycgE, ycgF, ycgG" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(315626..315645) /Source="Nicolas_upshift_promotors" /id="U225" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.501498501498502" /psig="0.999000999001" /xcortree=2540 /SigmaFactorBS="ccaactcacttctggaatttcttGTTGACAactgacagtcct ccCTATAAAATCGAGTTTATCTtgataatcgagatattcaacaatcaaactattatca t" /listShort="mdr" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(315629) /Source="Nicolas_upshifts" /id="U225" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.501498501498502" /psig="0.999000999001" /xcortree=2540 /SigmaFactorBS="ccaactcacttctggaatttcttGTTGACAactgacagtcct ccCTATAAAATCGAGTTTATCTtgataatcgagatattcaacaatcaaactattatca t" /listShort="mdr" /GFF_Attribute="listLong" /label="upshifts" CDS 315659..316123 /gene="ycgE" /locus_tag="BSU_03080" /old_locus_tag="BSU03080" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_388190.2" /db_xref="EnsemblGenomes-Gn:BSU03080" /db_xref="EnsemblGenomes-Tr:CAB12102" /db_xref="GOA:O31472" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12003" /db_xref="UniProtKB/Swiss-Prot:O31472" /translation="MSTRNSRSELEKTAVQLFRKLGTRTVLFHQAAAQALGLFPTDLK SADILNEAGPMTAGELGKKTGLSTGSVTALVDRLEKAGYVAREKDPNDRRRVVIVPLT ASKKHIKDLFRPLSESTMDLCREYTEEELELIFSFVGKAADIMEEELERLKQ*" /label="ycgE CDS" gene 315659..316123 /gene="ycgE" /locus_tag="BSU_03080" /old_locus_tag="BSU03080" /label="ycgE gene" promotor_-35 complement(315660..315666) /Source="Nicolas_upshift_promotors" /id="U225" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.501498501498502" /psig="0.999000999001" /xcortree=2540 /SigmaFactorBS="ccaactcacttctggaatttcttGTTGACAactgacagtcct ccCTATAAAATCGAGTTTATCTtgataatcgagatattcaacaatcaaactattatca t" /listShort="mdr" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 316133..316138 /Source="Nicolas_upshift_promotors" /id="U226" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=970 /SigmaFactorBS="ttgaacgtctgaaacagtaagtgaatttgTGCATAgcttggc ccgttcccGAATAAATTGTACAAGTTAcataagagaagggagtacgggccggtgaaca t" /listShort="ycgF, ycgG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 316154..316172 /Source="Nicolas_upshift_promotors" /id="U226" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=970 /SigmaFactorBS="ttgaacgtctgaaacagtaagtgaatttgTGCATAgcttggc ccgttcccGAATAAATTGTACAAGTTAcataagagaagggagtacgggccggtgaaca t" /listShort="ycgF, ycgG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 316164 /Source="Nicolas_upshifts" /id="U226" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=970 /SigmaFactorBS="ttgaacgtctgaaacagtaagtgaatttgTGCATAgcttggc ccgttcccGAATAAATTGTACAAGTTAcataagagaagggagtacgggccggtgaaca t" /listShort="ycgF, ycgG" /GFF_Attribute="listLong" /label="upshifts" CDS 316197..316826 /gene="ycgF" /locus_tag="BSU_03090" /old_locus_tag="BSU03090" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative aminoacid export permease" /protein_id="NP_388191.1" /db_xref="EnsemblGenomes-Gn:BSU03090" /db_xref="EnsemblGenomes-Tr:CAB12103" /db_xref="GOA:P94381" /db_xref="InterPro:IPR001123" /db_xref="SubtiList:BG12004" /db_xref="UniProtKB/Swiss-Prot:P94381" /translation="MNIFLSYIVLGLSLSAPVGPVNAAQIDKGIKNGFWHAWIFGLGA MTADGLYMLFIYFGLSQFLTAPFVKTFLWLFGFFVLTYTGIETLKNVREPMDVRSSRG KPSYRKTFASGFLISLSNPLSILFWLGIYGSILAKTAEAYNMNQLLIYSSGIMIGILI WDFCMAITASTFRNLLHEKLLRGLTGIAGVSLLVFGFYFGYQGIKQLLG*" /label="ycgF CDS" gene 316197..316826 /gene="ycgF" /locus_tag="BSU_03090" /old_locus_tag="BSU03090" /label="ycgF gene" promotor_-35 316837..316846 /Source="Nicolas_upshift_promotors" /id="U227" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1281 /SigmaFactorBS="caaacagttattgggctgattcatgaaggACAGTCACCTgcc gcttccagttTTAATATAGTATCCAGATGAtactggaggtggatcaatggtgaatggg a" /listShort="ycgG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 316860..316879 /Source="Nicolas_upshift_promotors" /id="U227" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1281 /SigmaFactorBS="caaacagttattgggctgattcatgaaggACAGTCACCTgcc gcttccagttTTAATATAGTATCCAGATGAtactggaggtggatcaatggtgaatggg a" /listShort="ycgG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 316868 /Source="Nicolas_upshifts" /id="U227" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1281 /SigmaFactorBS="caaacagttattgggctgattcatgaaggACAGTCACCTgcc gcttccagttTTAATATAGTATCCAGATGAtactggaggtggatcaatggtgaatggg a" /listShort="ycgG" /GFF_Attribute="listLong" /label="upshifts" CDS 316896..317657 /gene="ycgG" /locus_tag="BSU_03100" /old_locus_tag="BSU03100" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (similar to phage protein)" /protein_id="NP_388192.2" /db_xref="EnsemblGenomes-Gn:BSU03100" /db_xref="EnsemblGenomes-Tr:CAB12104" /db_xref="InterPro:IPR014988" /db_xref="SubtiList:BG12005" /db_xref="UniProtKB/Swiss-Prot:P94382" /translation="MVNGIYTKSFLERIQEELPEWQRIAFELLAETLGDDADTFPCIP GRQAFLTDQLRIAFAGDPRENRTAEELAPLLAEYGKISRDTGKYASLVVLFDTPEDLA EHYSIEAYEELFWRFLNRLSHQDEKEWPEDIPADPEHYKWEFCFDGEPYFILCATPGH EARRSRSFPFFMVTFQPRWVFDDLNGSTAFGRNMSRLIRSRLEAYDQAPIHPQLGWYG GKDNREWKQYFLRDDEKQVSKCPFSYLKNMFNKMK*" /label="ycgG CDS" gene 316896..317657 /gene="ycgG" /locus_tag="BSU_03100" /old_locus_tag="BSU03100" /label="ycgG gene" S_feature complement(317296..317658) /Source="Nicolas_S_feature" /locus_tag="new_335729_336091_c" /HighExp="S8, S7, S5, S6, S4, nit, ferm, BT, Pyr, G/S" /AntisenseName="ycgG" /AntisenseCor="0.73875580854115197" /AntisenseRegPval="-46.9" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S109" downshifts 317654 /Source="Nicolas_upshifts" /id="D135" /incds=0 /nref=21 /ntot=174 /MaxReadThrough="1.53211" /MaxDrop="4.92685" /score="6.36985882" /energy="-8.6" /TU="NA" /idTUdmin="U227" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" CDS complement(317659..318999) /gene="ycgH" /locus_tag="BSU_03110" /old_locus_tag="BSU03110" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative amino acid transporter" /protein_id="NP_388193.2" /db_xref="EnsemblGenomes-Gn:BSU03110" /db_xref="EnsemblGenomes-Tr:CAB12105" /db_xref="GOA:P94383" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG12006" /db_xref="UniProtKB/Swiss-Prot:P94383" /translation="MSQTKKDQPKGNLAWWQLSLIGVGCTIGTGFFLGSSIAIVKSGF SVLLSFLIAGIGTYFVFEQLAKLSAKQPEKGSFCAYARKAFGKWAGFSNGWVYWTSEM LITGSQLTAISLFTKHWFPQVPLWVFASIYAVLGLLIIFTGLSVFEKTENVLAVIKTA AIFMFIVIAILALCGILSGGNHGIHVPNKTSEFFPYGAMGLWTGLIYAFYAFGGIEVM GLMAVHLKKPEEASKSGKLMLATLAIIYIISIGLALLLVPLHTFTEQDSPFITSLKGY NLEIILDIFNGIFIIAGFSTLVASLFAVTTLLCTMADDGDAPKCFTLKEGKKICWPAL GLTFAGLVLSIILSLVLPKNIYEHMTTAAGLMLLYTWLFILFSSKKLTDPEGMGKTQI YLAMVLIAAAVSGTLFEKSSRPGFFVSIGFLVIIAIVTMIYQKKQGHKDRPASP*" /label="ycgH CDS" gene complement(317659..318999) /gene="ycgH" /locus_tag="BSU_03110" /old_locus_tag="BSU03110" /label="ycgH gene" promotor_-10 complement(319026..319037) /Source="Nicolas_upshift_promotors" /id="U228" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=918 /SigmaFactorBS="ctgcttccttctccatgtaaaaagaggcaaaaatccgaTGTA TATaagctttggacagaTCACAATCTAACcttagataaaaggggttgaataaataatg a" /listShort="ycgH, S109" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(319036) /Source="Nicolas_upshifts" /id="U228" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=918 /SigmaFactorBS="ctgcttccttctccatgtaaaaagaggcaaaaatccgaTGTA TATaagctttggacagaTCACAATCTAACcttagataaaaggggttgaataaataatg a" /listShort="ycgH, S109" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(319052..319058) /Source="Nicolas_upshift_promotors" /id="U228" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=918 /SigmaFactorBS="ctgcttccttctccatgtaaaaagaggcaaaaatccgaTGTA TATaagctttggacagaTCACAATCTAACcttagataaaaggggttgaataaataatg a" /listShort="ycgH, S109" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 319078..319084 /Source="Nicolas_upshift_promotors" /id="U229" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=817 /SigmaFactorBS="ttgtgatctgtccaaagcttatatacatcggatttttgcctc ttttTACATGGagaaggaagcagacGCTCATACTAATgaaaaaaggagcaaaccaatg a" /listShort="ycgI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 319092 /Source="Nicolas_upshifts" /id="U229" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=817 /SigmaFactorBS="ttgtgatctgtccaaagcttatatacatcggatttttgcctc ttttTACATGGagaaggaagcagacGCTCATACTAATgaaaaaaggagcaaaccaatg a" /listShort="ycgI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 319099..319110 /Source="Nicolas_upshift_promotors" /id="U229" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=817 /SigmaFactorBS="ttgtgatctgtccaaagcttatatacatcggatttttgcctc ttttTACATGGagaaggaagcagacGCTCATACTAATgaaaaaaggagcaaaccaatg a" /listShort="ycgI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 319129..319725 /gene="ycgI" /locus_tag="BSU_03120" /old_locus_tag="BSU03120" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 16433904, 28898812; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xenotiotic metabolite methyltransferase" /protein_id="NP_388194.3" /db_xref="EnsemblGenomes-Gn:BSU03120" /db_xref="EnsemblGenomes-Tr:CAB12106" /db_xref="InterPro:IPR018959" /db_xref="SubtiList:BG12007" /db_xref="UniProtKB/Swiss-Prot:O31473" /translation="MTQQYIVEPKKGLGLKLKKGQILKVVDVEGQQVADFVAYHAKDF YEHLDQGATIDANHSIHVKVNDHLYSNLYKPMLTLIEDTVGKHDLLLPACRPDMNRLL YGKQKDEFQDTCYDNMNRALEQFGVPKPHMHYPFAIFMNTVLDEKGNLSVETPLSNAG DYVRLRAEMDLIVAFSSCPIEKGKCNGDSVTSIRVEVS*" /label="ycgI CDS" gene 319129..319725 /gene="ycgI" /locus_tag="BSU_03120" /old_locus_tag="BSU03120" /label="ycgI gene" promotor_-35 319733..319740 /Source="Nicolas_upshift_promotors" /id="U230" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.471528471528472" /psig="0.99100899100899" /xcortree=104 /SigmaFactorBS="gtgtgacatccatacgggttgaagtcagctgatctctctTGT TCACAgtgaatgaagaccTGTGCTATATTTAATAGGGAtacataacagtcatgattca t" /listShort="S110, nadE" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 319754..319854 /Source="Nicolas_S_feature" /locus_tag="new_338187_338287" /HighExp="dia15, LBGtran, dia5, Etha, dia0, LBGexp, M0t45, Lbexp, Diami, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S110" promotor_-10 319754..319773 /Source="Nicolas_upshift_promotors" /id="U230" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.471528471528472" /psig="0.99100899100899" /xcortree=104 /SigmaFactorBS="gtgtgacatccatacgggttgaagtcagctgatctctctTGT TCACAgtgaatgaagaccTGTGCTATATTTAATAGGGAtacataacagtcatgattca t" /listShort="S110, nadE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 319754 /Source="Nicolas_upshifts" /id="U230" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.471528471528472" /psig="0.99100899100899" /xcortree=104 /SigmaFactorBS="gtgtgacatccatacgggttgaagtcagctgatctctctTGT TCACAgtgaatgaagaccTGTGCTATATTTAATAGGGAtacataacagtcatgattca t" /listShort="S110, nadE" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(319850) /Source="Nicolas_upshifts" /id="D136" /incds=0 /nref=3 /ntot=24 /MaxReadThrough="1.2989" /MaxDrop="4.67402" /score="15.0992897" /energy="-14.1" /TU="NA" /idTUdmin="U233" /TUdmin=1562 /isTUend="FALSE" /label="downshifts" CDS 319855..320673 /gene="nadE" /locus_tag="BSU_03130" /old_locus_tag="BSU03130" /EC_number="6.3.1.5" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7890752, 9271869, 12682299, 19204287" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7890752, 9271869, 12682299, 19204287; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ammonium-dependent NAD+ synthetase" /protein_id="NP_388195.1" /db_xref="EnsemblGenomes-Gn:BSU03130" /db_xref="EnsemblGenomes-Tr:CAB12107" /db_xref="GOA:P08164" /db_xref="InterPro:IPR003694" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR022310" /db_xref="InterPro:IPR022926" /db_xref="PDB:1EE1" /db_xref="PDB:1FYD" /db_xref="PDB:1IFX" /db_xref="PDB:1IH8" /db_xref="PDB:1KQP" /db_xref="PDB:1NSY" /db_xref="PDB:2NSY" /db_xref="SubtiList:BG10694" /db_xref="UniProtKB/Swiss-Prot:P08164" /translation="MSMQEKIMRELHVKPSIDPKQEIEDRVNFLKQYVKKTGAKGFVL GISGGQDSTLAGRLAQLAVESIREEGGDAQFIAVRLPHGTQQDEDDAQLALKFIKPDK SWKFDIKSTVSAFSDQYQQETGDQLTDFNKGNVKARTRMIAQYAIGGQEGLLVLGTDH AAEAVTGFFTKYGDGGADLLPLTGLTKRQGRTLLKELGAPERLYLKEPTADLLDEKPQ QSDETELGISYDEIDDYLEGKEVSAKVSEALEKRYSMTEHKRQVPASMFDDWWK*" /label="nadE CDS" gene 319855..320673 /gene="nadE" /locus_tag="BSU_03130" /old_locus_tag="BSU03130" /label="nadE gene" downshifts 320655 /Source="Nicolas_upshifts" /id="D137" /incds=0 /nref=144 /ntot=271 /MaxReadThrough="2.68866" /MaxDrop="6.24927" /score="20.6612287" /energy="-14.1" /TU="U230" /idTUdmin="U230" /TUdmin="-65" /isTUend="FALSE" /label="downshifts" CDS complement(320723..321316) /gene="tmrB" /locus_tag="BSU_03140" /old_locus_tag="BSU03140" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:1624425, 7766032, 15131133, 27315722" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1624425, 7766032, 15131133, 27315722; Product type f: factor" /codon_start=1 /transl_table=11 /product="ATP-binding tunicamycin resistance protein" /protein_id="NP_388196.2" /db_xref="EnsemblGenomes-Gn:BSU03140" /db_xref="EnsemblGenomes-Tr:CAB12108" /db_xref="GOA:P12921" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10456" /db_xref="UniProtKB/Swiss-Prot:P12921" /translation="MIIWINGAFGSGKTQTAFELHRRLNPSYVYDPEKMGFALRSMVP QEIAKDDFQSYPLWRAFNYSLLASLTDTYRGILIVPMTIVHPEYFNEIIGRLRQEGRI VHHFTLMASKETLLKRLRTRAEGKNSWAAKQIDRCVEGLSSPIFEDHIQTDNLSIQDV AENIAARAELPLDPDTRGSLRRFADRLMVKLNHIRIK*" /label="tmrB CDS" gene complement(320723..321316) /gene="tmrB" /locus_tag="BSU_03140" /old_locus_tag="BSU03140" /label="tmrB gene" downshifts complement(320730) /Source="Nicolas_upshifts" /id="D138" /incds=0 /nref=10 /ntot=143 /MaxReadThrough="0.60282" /MaxDrop="3.74815" /score="15.0992897" /energy="-14.1" /TU="NA" /idTUdmin="U233" /TUdmin=682 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(321331..321350) /Source="Nicolas_upshift_promotors" /id="U231" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.999000999001" /xcortree=3131 /SigmaFactorBS="gttaaaaccttccgcctttattgtttttccagctgactCTTC gatggaagggtcttTTTCTGTATGATAAATAGGAagggagaaatggcgatgatcattt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(321346) /Source="Nicolas_upshifts" /id="U231" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.999000999001" /xcortree=3131 /SigmaFactorBS="gttaaaaccttccgcctttattgtttttccagctgactCTTC gatggaagggtcttTTTCTGTATGATAAATAGGAagggagaaatggcgatgatcattt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(321365..321368) /Source="Nicolas_upshift_promotors" /id="U231" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.999000999001" /xcortree=3131 /SigmaFactorBS="gttaaaaccttccgcctttattgtttttccagctgactCTTC gatggaagggtcttTTTCTGTATGATAAATAGGAagggagaaatggcgatgatcattt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(321374..321522) /Source="Nicolas_S_feature" /locus_tag="new_339807_339955_c" /HighExp="S4, S3, S6, S5, S7, BT, S8, LoTm, T5.0H, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S111" promotor_-35 321424..321431 /Source="Nicolas_upshift_promotors" /id="U232" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.495504495504495" /psig="0.997002997002997" /xcortree=3017 /SigmaFactorBS="aaaggcggaaggttttaacgcttttttgcgtcgaagTATTAA AAtacctgcagaaaTGTTGTACAATGAATGTCATtcaggcaaaaatggctacaacaaa g" /listShort="S112, aroK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 321444..321463 /Source="Nicolas_upshift_promotors" /id="U232" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.495504495504495" /psig="0.997002997002997" /xcortree=3017 /SigmaFactorBS="aaaggcggaaggttttaacgcttttttgcgtcgaagTATTAA AAtacctgcagaaaTGTTGTACAATGAATGTCATtcaggcaaaaatggctacaacaaa g" /listShort="S112, aroK" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 321446..321554 /Source="Nicolas_S_feature" /locus_tag="new_339879_339987" /HighExp="Diami, BMM, GM 15, GM 25, GM 120, GM 60, GM 10, G180, GM 45, M9-exp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S112" upshifts 321448 /Source="Nicolas_upshifts" /id="U232" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.495504495504495" /psig="0.997002997002997" /xcortree=3017 /SigmaFactorBS="aaaggcggaaggttttaacgcttttttgcgtcgaagTATTAA AAtacctgcagaaaTGTTGTACAATGAATGTCATtcaggcaaaaatggctacaacaaa g" /listShort="S112, aroK" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(321516..321534) /Source="Nicolas_upshift_promotors" /id="U233" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1121 /SigmaFactorBS="tcttcggcgaaatcctcctaaggaatgaaattatataTTCAT TatatgcttatttagcGAATATTTATATAGATACCggctttaccggtcaagcttatag t" /listShort="S111" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 321522..321529 /Source="Nicolas_upshift_promotors" /id="U234" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.943056943056943" /psig="0.988011988011988" /xcortree=1750 /SigmaFactorBS="taagcttgaccggtaaagccggtatcTATATAAAtattcgct aaataaGCATATAATGAATATATAATttcattccttaggaggatttcgccgaagatga a" /listShort="aroK" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(321532) /Source="Nicolas_upshifts" /id="U233" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1121 /SigmaFactorBS="tcttcggcgaaatcctcctaaggaatgaaattatataTTCAT TatatgcttatttagcGAATATTTATATAGATACCggctttaccggtcaagcttatag t" /listShort="S111" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 321544..321563 /Source="Nicolas_upshift_promotors" /id="U234" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.943056943056943" /psig="0.988011988011988" /xcortree=1750 /SigmaFactorBS="taagcttgaccggtaaagccggtatcTATATAAAtattcgct aaataaGCATATAATGAATATATAATttcattccttaggaggatttcgccgaagatga a" /listShort="aroK" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(321550..321555) /Source="Nicolas_upshift_promotors" /id="U233" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1121 /SigmaFactorBS="tcttcggcgaaatcctcctaaggaatgaaattatataTTCAT TatatgcttatttagcGAATATTTATATAGATACCggctttaccggtcaagcttatag t" /listShort="S111" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 321556 /Source="Nicolas_upshifts" /id="U234" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.943056943056943" /psig="0.988011988011988" /xcortree=1750 /SigmaFactorBS="taagcttgaccggtaaagccggtatcTATATAAAtattcgct aaataaGCATATAATGAATATATAATttcattccttaggaggatttcgccgaagatga a" /listShort="aroK" /GFF_Attribute="listLong" /label="upshifts" CDS 321592..322152 /gene="aroK" /locus_tag="BSU_03150" /old_locus_tag="BSU03150" /EC_number="2.7.1.71" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 170268, 7612934, 27339308; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="shikimate kinase" /protein_id="NP_388197.2" /db_xref="EnsemblGenomes-Gn:BSU03150" /db_xref="EnsemblGenomes-Tr:CAB12109" /db_xref="GOA:P37944" /db_xref="InterPro:IPR000623" /db_xref="InterPro:IPR023000" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031322" /db_xref="SubtiList:BG10457" /db_xref="UniProtKB/Swiss-Prot:P37944" /translation="MNAKRAIPVRERNIVLIGFMGVGKTTIGQLVAKKLYRDFIDIDQ QIEKDFNMSIPEIFEKKGEDFFRKTEKEYILDICHHKRFKIVSLGGGSFKQEEIRNCC LENCLVLHLDLSWENWKQRADLLIESRPVLHNRSMDEMEQLFNERKVIYDKHNSKVAT DNLSPEEVADYIVETLKIGWDLYQPM*" /label="aroK CDS" gene 321592..322152 /gene="aroK" /locus_tag="BSU_03150" /old_locus_tag="BSU03150" /label="aroK gene" downshifts 322129 /Source="Nicolas_upshifts" /id="D139" /incds=0 /nref=21 /ntot=239 /MaxReadThrough="2.07607" /MaxDrop="4.67156" /score="44.9099474" /energy="-13.1" /TU="NA" /idTUdmin="U232" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(322180..322941) /gene="ycgJ" /locus_tag="BSU_03160" /old_locus_tag="BSU03160" /EC_number="2.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 28898812; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xenotiotic metabolite methyltransferase" /protein_id="NP_388198.2" /db_xref="EnsemblGenomes-Gn:BSU03160" /db_xref="EnsemblGenomes-Tr:CAB12110" /db_xref="GOA:O31474" /db_xref="InterPro:IPR013216" /db_xref="InterPro:IPR029063" /db_xref="PDB:1XXL" /db_xref="PDB:2GLU" /db_xref="SubtiList:BG12008" /db_xref="UniProtKB/Swiss-Prot:O31474" /translation="MTNETPFSKNAEMYRDEKVFAEGEDLGLMIKTAECRAEHRVLDI GAGAGHTALAFSPYVQECIGVDATKEMVEVASSFAQEKGVENVRFQQGTAESLPFPDD SFDIITCRYAAHHFSDVRKAVREVARVLKQDGRFLLVDHYAPEDPVLDEFVNHLNRLR DPSHVRESSLSEWQAMFSANQLAYQDIQKWNLPIQYDSWIKRGGTPADREKQIITHLN HASDEARDTFCITLNQNGQPISFCLKAILIQGIKR*" /label="ycgJ CDS" gene complement(322180..322941) /gene="ycgJ" /locus_tag="BSU_03160" /old_locus_tag="BSU03160" /label="ycgJ gene" downshifts complement(322204) /Source="Nicolas_upshifts" /id="D140" /incds=0 /nref=3 /ntot=55 /MaxReadThrough="0.31391" /MaxDrop="3.85249" /score="18.9843263" /energy="-13.1" /TU="NA" /idTUdmin="U235" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(322973..322992) /Source="Nicolas_upshift_promotors" /id="U235" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.392607392607393" /psig="0.942057942057942" /xcortree=1808 /SigmaFactorBS="acctatcattttcatcatttttatatcTTGGACgaatcataa cagaaATTGCTAACATAATCCATATcatcatttacgaaaagaaggagctggttcaaat g" /listShort="ycgJ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 322974..322981 /Source="Nicolas_upshift_promotors" /id="U236" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.662337662337662" /psig="0.983016983016983" /xcortree=1867 /SigmaFactorBS="cagctccttcttttcgtaaatgatgaTATGGATTatgttagc aatttcTGTTATGATTCGTCCAAGATataaaaatgatgaaaatgataggttcaaccta t" /listShort="ycgK, S113, cah, S114, ycgL" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(322979) /Source="Nicolas_upshifts" /id="U235" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.392607392607393" /psig="0.942057942057942" /xcortree=1808 /SigmaFactorBS="acctatcattttcatcatttttatatcTTGGACgaatcataa cagaaATTGCTAACATAATCCATATcatcatttacgaaaagaaggagctggttcaaat g" /listShort="ycgJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 322996..323015 /Source="Nicolas_upshift_promotors" /id="U236" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.662337662337662" /psig="0.983016983016983" /xcortree=1867 /SigmaFactorBS="cagctccttcttttcgtaaatgatgaTATGGATTatgttagc aatttcTGTTATGATTCGTCCAAGATataaaaatgatgaaaatgataggttcaaccta t" /listShort="ycgK, S113, cah, S114, ycgL" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(323007..323012) /Source="Nicolas_upshift_promotors" /id="U235" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.392607392607393" /psig="0.942057942057942" /xcortree=1808 /SigmaFactorBS="acctatcattttcatcatttttatatcTTGGACgaatcataa cagaaATTGCTAACATAATCCATATcatcatttacgaaaagaaggagctggttcaaat g" /listShort="ycgJ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 323008 /Source="Nicolas_upshifts" /id="U236" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.662337662337662" /psig="0.983016983016983" /xcortree=1867 /SigmaFactorBS="cagctccttcttttcgtaaatgatgaTATGGATTatgttagc aatttcTGTTATGATTCGTCCAAGATataaaaatgatgaaaatgataggttcaaccta t" /listShort="ycgK, S113, cah, S114, ycgL" /GFF_Attribute="listLong" /label="upshifts" CDS 323059..324033 /gene="ycgK" /locus_tag="BSU_03170" /old_locus_tag="BSU03170" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10939241; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (LysR family)" /protein_id="NP_388199.2" /db_xref="EnsemblGenomes-Gn:BSU03170" /db_xref="EnsemblGenomes-Tr:CAB12111" /db_xref="GOA:P94387" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12009" /db_xref="UniProtKB/Swiss-Prot:P94387" /translation="MDIKVMEYAAEIARRQSFTKAAEHLHIAQPSLSQQIKKLEAELG LTLFHRSHGSVTLTPHGRRFIEKAEDIIRSRDDLLREMQERSQGIGHKLSIGIPAVTG RYLFPPLLKQFLARYPHVEVQLVEKDPVSLEKMTAKGEVDLSVLSLPIEDERLSITPL LTEPVVLAVPKEKQRWMPPELVALIEKALEEDEGRQPCVPIDMVRNVPFILLKEGFGF RRTVLDLCAESGFKPNAAFKTSHIETAQSLVANGLGVTMAPNMVRRDKDPGVIYLSIQ SAPSRTLVFVFLKNRYVSLTAQAFMELSRESLKQTFDEGCLGNKDENI*" /label="ycgK CDS" gene 323059..324033 /gene="ycgK" /locus_tag="BSU_03170" /old_locus_tag="BSU03170" /label="ycgK gene" S_feature 324034..324104 /Source="Nicolas_S_feature" /locus_tag="new_342467_342537" /HighExp="Diami, dia5, dia15, S1, dia0, C90, LBGexp, Heat, Lbexp, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.983" /TUlongSig="NA" /TUlongPSig="NA" /label="S113" CDS 324105..325061 /gene="cah" /locus_tag="BSU_03180" /old_locus_tag="BSU03180" /EC_number="3.1.1.41" /EC_number="3.1.1.72" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12842474, 19837798, 21382014" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12842474, 19837798, 21382014; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous acetyl xylan esterase-cephalosporin C deacetylase" /protein_id="NP_388200.1" /db_xref="EnsemblGenomes-Gn:BSU03180" /db_xref="EnsemblGenomes-Tr:CAB12112" /db_xref="GOA:P94388" /db_xref="InterPro:IPR008391" /db_xref="InterPro:IPR029058" /db_xref="PDB:1L7A" /db_xref="PDB:1ODS" /db_xref="PDB:1ODT" /db_xref="SubtiList:BG11919" /db_xref="UniProtKB/Swiss-Prot:P94388" /translation="MQLFDLPLDQLQTYKPEKTAPKDFSEFWKLSLEELAKVQAEPDL QPVDYPADGVKVYRLTYKSFGNARITGWYAVPDKEGPHPAIVKYHGYNASYDGEIHEM VNWALHGYATFGMLVRGQQSSEDTSISPHGHALGWMTKGILDKDTYYYRGVYLDAVRA LEVISSFDEVDETRIGVTGGSQGGGLTIAAAALSDIPKAAVADYPYLSNFERAIDVAL EQPYLEINSFFRRNGSPETEVQAMKTLSYFDIMNLADRVKVPVLMSIGLIDKVTPPST VFAAYNHLETKKELKVYRYFGHEYIPAFQTEKLAFFKQHLKG*" /label="cah CDS" gene 324105..325061 /gene="cah" /locus_tag="BSU_03180" /old_locus_tag="BSU03180" /label="cah gene" promotor_-35 324520..324526 /Source="Nicolas_upshift_promotors" /id="U237" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=806 /SigmaFactorBS="ttcaccgcacggtcacgctttgggctggatgaCGAAAGGaat tcttgataaagATACATACTATTaccgcggtgtttatttggacgccgtccgcgcgctt g" /listShort="S114, ycgL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 324541..324552 /Source="Nicolas_upshift_promotors" /id="U237" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=806 /SigmaFactorBS="ttcaccgcacggtcacgctttgggctggatgaCGAAAGGaat tcttgataaagATACATACTATTaccgcggtgtttatttggacgccgtccgcgcgctt g" /listShort="S114, ycgL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 324548 /Source="Nicolas_upshifts" /id="U237" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=806 /SigmaFactorBS="ttcaccgcacggtcacgctttgggctggatgaCGAAAGGaat tcttgataaagATACATACTATTaccgcggtgtttatttggacgccgtccgcgcgctt g" /listShort="S114, ycgL" /GFF_Attribute="listLong" /label="upshifts" S_feature 325062..325140 /Source="Nicolas_S_feature" /locus_tag="new_343495_343573" /HighExp="dia5, dia15, Diami, dia0, B36, S1, MG 10, BT, B60, MG t5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigA" /TUshortPSig="0.998, 0.983" /TUlongSig="NA" /TUlongPSig="NA" /label="S114" promotor_-35 325115..325120 /Source="Nicolas_upshift_promotors" /id="U238" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1193 /SigmaFactorBS="atatcatcaggcggtttttttctgcaaactgccGGAATGaga acagactggagacGAATAGATATGAAACAAAGaatcattgatgaattaaaacggatcg a" /listShort="ycgL, S115, ycgM, ycgN, S116, ycgO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 325137..325155 /Source="Nicolas_upshift_promotors" /id="U238" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1193 /SigmaFactorBS="atatcatcaggcggtttttttctgcaaactgccGGAATGaga acagactggagacGAATAGATATGAAACAAAGaatcattgatgaattaaaacggatcg a" /listShort="ycgL, S115, ycgM, ycgN, S116, ycgO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 325142 /Source="Nicolas_upshifts" /id="U238" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1193 /SigmaFactorBS="atatcatcaggcggtttttttctgcaaactgccGGAATGaga acagactggagacGAATAGATATGAAACAAAGaatcattgatgaattaaaacggatcg a" /listShort="ycgL, S115, ycgM, ycgN, S116, ycgO" /GFF_Attribute="listLong" /label="upshifts" CDS 325145..325927 /gene="ycgL" /locus_tag="BSU_03190" /old_locus_tag="BSU03190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388201.1" /db_xref="EnsemblGenomes-Gn:BSU03190" /db_xref="EnsemblGenomes-Tr:CAB12113" /db_xref="InterPro:IPR018775" /db_xref="SubtiList:BG12010" /db_xref="UniProtKB/Swiss-Prot:P94389" /translation="MKQRIIDELKRIEQSYGVKIVYAVESGSRAWGFPSQDSDYDVRF IYVPKKEWYFSIEQERDVIEEPIHDLLDISGWELRKTLRLFKKSNPPLLEWLSSDIVY YEAFTTAEQLRKLRTEAFKPEASVYHYINMARRNVKDYLQGQEVKIKKYFYVLRPILA CQWIEKHGTIPPMDFTVLMNELVAEPELKAEMETLLERKRRGEELDLEARIDVIHQFI ETEIERIMEAAKELKAEKKDMTSELNRLLLNTVEEVWKDGGS*" /label="ycgL CDS" gene 325145..325927 /gene="ycgL" /locus_tag="BSU_03190" /old_locus_tag="BSU03190" /label="ycgL gene" downshifts 325892 /Source="Nicolas_upshifts" /id="D141" /incds=0 /nref=11 /ntot=63 /MaxReadThrough="3.94077" /MaxDrop="4.37398" /score="0.421649027" /energy="-5.9" /TU="U238" /idTUdmin="U236" /TUdmin=2 /isTUend="TRUE" /label="downshifts" S_feature 325937..326064 /Source="Nicolas_S_feature" /locus_tag="new_344370_344497" /HighExp="S5, S6, S8, S4, S7, B36, B60, BT, S3, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S115" promotor_-35 326041..326045 /Source="Nicolas_upshift_promotors" /id="U239" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.472527472527473" /psig="0.922077922077922" /xcortree=391 /SigmaFactorBS="cacaaaaataatcagaatctttgtattttgagaatATTGTga acgctggttttgTCCATTTACAATAAACTCATacaaatacttcttagattgcggggtg t" /listShort="ycgM, ycgN, S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 326060..326079 /Source="Nicolas_upshift_promotors" /id="U239" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.472527472527473" /psig="0.922077922077922" /xcortree=391 /SigmaFactorBS="cacaaaaataatcagaatctttgtattttgagaatATTGTga acgctggttttgTCCATTTACAATAAACTCATacaaatacttcttagattgcggggtg t" /listShort="ycgM, ycgN, S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 326066 /Source="Nicolas_upshifts" /id="U239" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.472527472527473" /psig="0.922077922077922" /xcortree=391 /SigmaFactorBS="cacaaaaataatcagaatctttgtattttgagaatATTGTga acgctggttttgTCCATTTACAATAAACTCATacaaatacttcttagattgcggggtg t" /listShort="ycgM, ycgN, S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="upshifts" CDS 326118..327029 /gene="putB" /locus_tag="BSU_03200" /old_locus_tag="BSU03200" /EC_number="1.5.5.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17536821, 2118500, 21840319, 22139509, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17536821, 2118500, 21840319, 22139509, 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="proline oxidase" /protein_id="NP_388202.1" /db_xref="EnsemblGenomes-Gn:BSU03200" /db_xref="EnsemblGenomes-Tr:CAB12114" /db_xref="GOA:P94390" /db_xref="InterPro:IPR002872" /db_xref="InterPro:IPR008219" /db_xref="InterPro:IPR015659" /db_xref="InterPro:IPR029041" /db_xref="SubtiList:BG12011" /db_xref="UniProtKB/Swiss-Prot:P94390" /translation="MITRDFFLFLSKSGFLNKMARNWGSRVAAGKIIGGNDFNSSIPT IRQLNSQGLSVTVDHLGEFVNSAEVARERTEECIQTIATIADQELNSHVSLKMTSLGL DIDMDLVYENMTKILQTAEKHKIMVTIDMEDEVRCQKTLDIFKDFRKKYEHVSTVLQA YLYRTEKDIDDLDSLNPFLRLVKGAYKESEKVAFPEKSDVDENYKKIIRKQLLNGHYT AIATHDDKMIDFTKQLAKEHGIANDKFEFQMLYGMRSQTQLSLVKEGYNMRVYLPYGE DWYGYFMRRLAERPSNIAFAFKGMTKK*" /label="putB CDS" gene 326118..327029 /gene="putB" /locus_tag="BSU_03200" /old_locus_tag="BSU03200" /label="putB gene" CDS 327046..328593 /gene="putC" /locus_tag="BSU_03210" /old_locus_tag="BSU03210" /EC_number="1.2.1.88" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11418582, 17183215, 21840319, 22139509, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418582, 17183215, 21840319, 22139509, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="1-pyrroline-5-carboxylate dehydrogenase" /protein_id="NP_388203.2" /db_xref="EnsemblGenomes-Gn:BSU03210" /db_xref="EnsemblGenomes-Tr:CAB12115" /db_xref="GOA:P94391" /db_xref="InterPro:IPR005932" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG12012" /db_xref="UniProtKB/Swiss-Prot:P94391" /translation="MTTPYKHEPFTNFQDQNNVEAFKKALATVSEYLGKDYPLVINGE RVETEAKIVSINPADKEEVVGRVSKASQEHAEQAIQAAAKAFEEWRYTSPEERAAVLF RAAAKVRRRKHEFSALLVKEAGKPWNEADADTAEAIDFMEYYARQMIELAKGKPVNSR EGEKNQYVYTPTGVTVVIPPWNFLFAIMAGTTVAPIVTGNTVVLKPASATPVIAAKFV EVLEESGLPKGVVNFVPGSGAEVGDYLVDHPKTSLITFTGSREVGTRIFERAAKVQPG QQHLKRVIAEMGGKDTVVVDEDADIELAAQSIFTSAFGFAGQKCSAGSRAVVHEKVYD QVLERVIEITESKVTAKPDSADVYMGPVIDQGSYDKIMSYIEIGKQEGRLVSGGTGDD SKGYFIKPTIFADLDPKARLMQEEIFGPVVAFCKVSDFDEALEVANNTEYGLTGAVIT NNRKHIERAKQEFHVGNLYFNRNCTGAIVGYHPFGGFKMSGTDSKAGGPDYLALHMQA KTISEMF*" /label="putC CDS" gene 327046..328593 /gene="putC" /locus_tag="BSU_03210" /old_locus_tag="BSU03210" /label="putC gene" promotor_-35 328017..328023 /Source="Nicolas_upshift_promotors" /id="U240" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.411588411588412" /psig="0.994005994005994" /xcortree=2488 /SigmaFactorBS="ggctttgcgggacaaaaatgctctgcaggttcACGTGCAgta gttcatgaaaAAGTGTATGATCAAGTATTAgagcgtgtcattgaaattacggaatcaa a" /listShort="S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 328037..328056 /Source="Nicolas_upshift_promotors" /id="U240" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.411588411588412" /psig="0.994005994005994" /xcortree=2488 /SigmaFactorBS="ggctttgcgggacaaaaatgctctgcaggttcACGTGCAgta gttcatgaaaAAGTGTATGATCAAGTATTAgagcgtgtcattgaaattacggaatcaa a" /listShort="S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 328045 /Source="Nicolas_upshifts" /id="U240" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.411588411588412" /psig="0.994005994005994" /xcortree=2488 /SigmaFactorBS="ggctttgcgggacaaaaatgctctgcaggttcACGTGCAgta gttcatgaaaAAGTGTATGATCAAGTATTAgagcgtgtcattgaaattacggaatcaa a" /listShort="S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 328128..328134 /Source="Nicolas_upshift_promotors" /id="U241" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.793206793206793" /psig=1 /xcortree=2403 /SigmaFactorBS="aaacctgacagtgcagatgtttatatgggaccTGTCATTgac caaggttctTATGATAAAATTATGAGCTAtattgagatcggaaaacaggaagggcgtt t" /listShort="S116, ycgO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 328147..328166 /Source="Nicolas_upshift_promotors" /id="U241" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.793206793206793" /psig=1 /xcortree=2403 /SigmaFactorBS="aaacctgacagtgcagatgtttatatgggaccTGTCATTgac caaggttctTATGATAAAATTATGAGCTAtattgagatcggaaaacaggaagggcgtt t" /listShort="S116, ycgO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 328156 /Source="Nicolas_upshifts" /id="U241" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.793206793206793" /psig=1 /xcortree=2403 /SigmaFactorBS="aaacctgacagtgcagatgtttatatgggaccTGTCATTgac caaggttctTATGATAAAATTATGAGCTAtattgagatcggaaaacaggaagggcgtt t" /listShort="S116, ycgO" /GFF_Attribute="listLong" /label="upshifts" misc_feature 328592..328596 /Source="Nicolas_upshift_promotors" /id="U242" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.315684315684316" /psig="0.248751248751249" /xcortree=3009 /SigmaFactorBS="cgggccggattacttggctctgcatatgcaagcaaaaacaat cagtgaaatgttctAAGCGggactaaatgggcatcctccctgcgggggtgtccatttc a" /listShort="S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 328594..328716 /Source="Nicolas_S_feature" /locus_tag="new_347027_347149" /HighExp="S1, T2.0H, T2.30H, Lbstat, aero, HiOs, BC, Sw, LPh, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.52312199999999998" /TUshortSig="Sig-, SigA, SigA, SigA, SigEF" /TUshortPSig="0.249, 1, 0.994, 0.922, 0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S116" upshifts 328596 /Source="Nicolas_upshifts" /id="U242" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.315684315684316" /psig="0.248751248751249" /xcortree=3009 /SigmaFactorBS="cgggccggattacttggctctgcatatgcaagcaaaaacaat cagtgaaatgttctAAGCGggactaaatgggcatcctccctgcgggggtgtccatttc a" /listShort="S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="upshifts" CDS 328717..330138 /gene="putP" /locus_tag="BSU_03220" /old_locus_tag="BSU03220" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11902719, 14976255, 15849754, 16850406, 21840319, 22139509, 24142252" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11902719, 14976255, 15849754, 16850406, 21840319, 22139509, 24142252; Product type t: transporter" /codon_start=1 /transl_table=11 /product="proline permease" /protein_id="NP_388204.2" /db_xref="EnsemblGenomes-Gn:BSU03220" /db_xref="EnsemblGenomes-Tr:CAB12116" /db_xref="GOA:P94392" /db_xref="InterPro:IPR001734" /db_xref="InterPro:IPR011851" /db_xref="InterPro:IPR018212" /db_xref="SubtiList:BG12013" /db_xref="UniProtKB/Swiss-Prot:P94392" /translation="MLLIGYFAYKRTSNLTDYMLGGRSLGPAVTALSAGAADMSGWLL MGLPGAMFSTGLSGAWIVIGLCLGAWANWLYVAPRLRTYTEKAGNSITIPGFLENRFG DQTKLLRLFSGIVILVFFTFYVSSGMVSGGVLFNSILGMDYHTGLWIVTGVVVAYTLF GGFLAVSWTDFVQGIIMFAALILVPIVTFFHTGGAGDTVAEIRSVDPDMFNIFKGTSV LGIISLFAWGLGYFGQPHIIVRFMAITSVKEIKRARRIGMGWMILSAVGAVLTGLGGI AYYHQRGMTLKDPETIFIQLGNILFHPIITGFLISAILAAIMSTISSQLLVTSSSLVE DLYKSMFRRSASDKELVFLGRLAVLAVSIVALVLAWEKNNTILGLVSYAWAGFGASFG PVVLLSLFWKRMTKWGALAGMIVGAATVIIWANAGLSDFLYEMIPGFAASLLSVFFVS ILTQAPSQAVTDQFNDYQDTMSQ*" /label="putP CDS" gene 328717..330138 /gene="putP" /locus_tag="BSU_03220" /old_locus_tag="BSU03220" /label="putP gene" S_feature complement(329237..331092) /Source="Nicolas_S_feature" /locus_tag="new_347670_349525_c" /HighExp="T1.0H, T1.30H, T0.30H, T2.0H, T2.30H, T3.0H, T3.30H, C30, T4.0H, Lbstat" /AntisenseName="ycgP" /AntisenseCor="0.143781082577395" /AntisenseRegPval="-1.7" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig="0.679" /TUlongSig="NA" /TUlongPSig="NA" /label="S117" downshifts 330118 /Source="Nicolas_upshifts" /id="D142" /incds=0 /nref=21 /ntot=160 /MaxReadThrough="5.09597" /MaxDrop="4.17771" /score="5.89792272" /energy="-15.9" /TU="U239,U240,U242" /idTUdmin="U238" /TUdmin=4 /isTUend="TRUE" /label="downshifts" S_feature 330163..330259 /Source="Nicolas_S_feature" /locus_tag="new_348596_348692" /HighExp="S1, LPh, T2.0H, HPh, aero, Lbstat, LoTm, T2.30H, Cold, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigA" /TUshortPSig="0.249, 0.994, 0.922" /TUlongSig="NA" /TUlongPSig="NA" /label="S118" promotor_-35 330230..330237 /Source="Nicolas_upshift_promotors" /id="U243" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2392 /SigmaFactorBS="tttttcttttggaaacaaacgtattttttTCTATACAaaaag accccgtatGGATATGATTAAAGTAAAAAaagtataggagaaaaaggtatggaagagc t" /listShort="ycgP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 330252..330271 /Source="Nicolas_upshift_promotors" /id="U243" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2392 /SigmaFactorBS="tttttcttttggaaacaaacgtattttttTCTATACAaaaag accccgtatGGATATGATTAAAGTAAAAAaagtataggagaaaaaggtatggaagagc t" /listShort="ycgP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 330261 /Source="Nicolas_upshifts" /id="U243" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2392 /SigmaFactorBS="tttttcttttggaaacaaacgtattttttTCTATACAaaaag accccgtatGGATATGATTAAAGTAAAAAaagtataggagaaaaaggtatggaagagc t" /listShort="ycgP" /GFF_Attribute="listLong" /label="upshifts" CDS 330291..331526 /gene="putR" /locus_tag="BSU_03230" /old_locus_tag="BSU03230" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:21840319, 21964733, 22139509" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21840319, 21964733, 22139509; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional activator of proline degradationoperon" /protein_id="NP_388205.2" /db_xref="EnsemblGenomes-Gn:BSU03230" /db_xref="EnsemblGenomes-Tr:CAB12117" /db_xref="GOA:P94393" /db_xref="InterPro:IPR025736" /db_xref="InterPro:IPR029016" /db_xref="SubtiList:BG12014" /db_xref="UniProtKB/Swiss-Prot:P94393" /translation="MEELLERVFSFSDVDKLIDFISYELQKPVILESADFFLLAYNSY YINHFDSANQQTIFSKKCPVQIFERFLKDGIIEKLKTEPEPFRVNKIESIGLNQRVVV SAKHKGEVMGYIWIQELDQNLTDEELDFLYETSFHVGKIIYKTNKLKQEKEEKAEDLI KRAIYQQFTSEKELRREAERINTVLPSMFSVVILHAANGDGEAVEDLKENIRSYLNLR DKVSHVLTIESNIVIVVASFSQKSSVSSAASEFINKLLTHFHFQKIPTPIYIGIGNEY NHLLKLGKSYTEALEVIKAAEITGNQENIPYEYAKLGIYRYLESIEQKNEFLEYENKD LALLKAKDEESSTELLKTLEIYLLNNCKTKPAAEQLFIHQNTLNYRIKQITEMTSIDL SDFRTRCQLYLDLMLMKKK*" /label="putR CDS" gene 330291..331526 /gene="putR" /locus_tag="BSU_03230" /old_locus_tag="BSU03230" /label="putR gene" promotor_-10 complement(331085..331103) /Source="Nicolas_upshift_promotors" /id="U244" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.679320679320679" /psig="0.679320679320679" /xcortree=1717 /SigmaFactorBS="tcaagtgcttctgtgtagctcttgccaagttttaatagGTGA TTATattcgtttccgatACCGATATAAATAGGGGTAggtattttttgaaagtgaaaat g" /listShort="S117" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(331102) /Source="Nicolas_upshifts" /id="U244" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.679320679320679" /psig="0.679320679320679" /xcortree=1717 /SigmaFactorBS="tcaagtgcttctgtgtagctcttgccaagttttaatagGTGA TTATattcgtttccgatACCGATATAAATAGGGGTAggtattttttgaaagtgaaaat g" /listShort="S117" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(331117..331124) /Source="Nicolas_upshift_promotors" /id="U244" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.679320679320679" /psig="0.679320679320679" /xcortree=1717 /SigmaFactorBS="tcaagtgcttctgtgtagctcttgccaagttttaatagGTGA TTATattcgtttccgatACCGATATAAATAGGGGTAggtattttttgaaagtgaaaat g" /listShort="S117" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(331510) /Source="Nicolas_upshifts" /id="D143" /incds=0 /nref=1 /ntot=5 /MaxReadThrough="0.0291099999999993" /MaxDrop="3.08474" /score="-9.94728494" /energy="-16.9" /TU="NA" /idTUdmin="U245" /TUdmin=66 /isTUend="FALSE" /label="downshifts" CDS complement(331563..332420) /gene="ycgQ" /locus_tag="BSU_03240" /old_locus_tag="BSU03240" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388206.1" /db_xref="EnsemblGenomes-Gn:BSU03240" /db_xref="EnsemblGenomes-Tr:CAB12118" /db_xref="GOA:P94394" /db_xref="InterPro:IPR015402" /db_xref="SubtiList:BG12015" /db_xref="UniProtKB/Swiss-Prot:P94394" /translation="MFRLLVLMGFTFFFYHLHASGNLTKYINMKYAYLSFIAIFLLAI LTAVQAYLFIKSPEKSGHHHDHDCGCGHDHEHDHEQNKPFYQRYLIYVVFLFPLVSGI FFPIATLDSSIVKTKGFSFKAMESGDHYSQTQYLRPDASLYYAQDSYDKQMKQLFNKY SSKKEISLTDDDFLKGMETIYNYPGEFLGRTIEFHGFAYKGNAINKNQLFVLRFGIIH CIADSGVYGMLVEFPKDMDIKDDEWIHIKGTLASEYYQPFKSTLPVVKVTDWNTIKKP DDPYVYRGF*" /label="ycgQ CDS" gene complement(331563..332420) /gene="ycgQ" /locus_tag="BSU_03240" /old_locus_tag="BSU03240" /label="ycgQ gene" downshifts complement(331576) /Source="Nicolas_upshifts" /id="D144" /incds=0 /nref=48 /ntot=167 /MaxReadThrough="1.97725" /MaxDrop="4.53007" /score="-9.94728494" /energy="-16.9" /TU="NA" /idTUdmin="U245" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(332425..333309) /gene="ycgR" /locus_tag="BSU_03250" /old_locus_tag="BSU03250" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388207.1" /db_xref="EnsemblGenomes-Gn:BSU03250" /db_xref="EnsemblGenomes-Tr:CAB12119" /db_xref="GOA:P94395" /db_xref="InterPro:IPR005524" /db_xref="SubtiList:BG12016" /db_xref="UniProtKB/Swiss-Prot:P94395" /translation="MTAQSSFLQLNSIFISILIEAIPFILIGVILSGIIQMFVSEEMI ARIMPKNRFLAVLFGALAGVLFPACECGIIPITRRLLLKGVPLHAGVAFMLTAPIINP IVLFSTYIAFGNRWSVVFYRGGLALAVSLIIGVILSYQFKDNQLLKPDEPGHHHHHHG TLLQKLGGTLRHAIDEFFSVGKYLIIGAFIAAAMQTYVKTSTLLAIGQNDVSSSLVMM GLAFVLSLCSEVDAFIASSFSSTFSLGSLIAFLVFGAMVDIKNLLMMLAAFKKRFVFL LITYIVVIVLAGSLLVKG*" /label="ycgR CDS" gene complement(332425..333309) /gene="ycgR" /locus_tag="BSU_03250" /old_locus_tag="BSU03250" /label="ycgR gene" upshifts complement(333361) /Source="Nicolas_upshifts" /id="U245" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.566433566433566" /psig="0.566433566433566" /xcortree=2523 /SigmaFactorBS="tttggaatcctaaccaaagTGAAACGATcctttcccctcctc CGTCAAACAAGCAGtgcctttttttctggtatcataagaaaggcagcttaacatgagc g" /listShort="ycgR, ycgQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(333366..333379) /Source="Nicolas_upshift_promotors" /id="U245" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.566433566433566" /psig="0.566433566433566" /xcortree=2523 /SigmaFactorBS="tttggaatcctaaccaaagTGAAACGATcctttcccctcctc CGTCAAACAAGCAGtgcctttttttctggtatcataagaaaggcagcttaacatgagc g" /listShort="ycgR, ycgQ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(333394..333402) /Source="Nicolas_upshift_promotors" /id="U245" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.566433566433566" /psig="0.566433566433566" /xcortree=2523 /SigmaFactorBS="tttggaatcctaaccaaagTGAAACGATcctttcccctcctc CGTCAAACAAGCAGtgcctttttttctggtatcataagaaaggcagcttaacatgagc g" /listShort="ycgR, ycgQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(333409..334263) /gene="ycgS" /locus_tag="BSU_03260" /old_locus_tag="BSU03260" /EC_number="3.7.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aromatic hydrocarbon hydrolase" /protein_id="NP_388208.1" /db_xref="EnsemblGenomes-Gn:BSU03260" /db_xref="EnsemblGenomes-Tr:CAB12120" /db_xref="GOA:P94396" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12017" /db_xref="UniProtKB/Swiss-Prot:P94396" /translation="MKRRVETITFDGGTLEYSVTGKGTPILVMHGGHSNCYEEFGYTA LIEQGYSIITPSRPGYGRTSKEIGKSLANACRFYVKLLDHLQIESVHVIAISAGGPSG ICFASHYPERVNTLTLQSAVTKEWLTPKDTEYKLGEILFRPPVEKWIWKLISSLNNAF PRLMFRAMSPQFSTLPFQRIKSLMNEKDIEAFRKMNSRQRSGEGFLIDLSQTAAVSLK DLQAIICPVLIMQSVYDGLVDLSHAHHAKEHIRGAVLCLLHSWGHLIWLGKEAAETGS ILLGFLES*" /label="ycgS CDS" gene complement(333409..334263) /gene="ycgS" /locus_tag="BSU_03260" /old_locus_tag="BSU03260" /label="ycgS gene" promotor_-10 complement(334282..334301) /Source="Nicolas_upshift_promotors" /id="U246" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.715284715284715" /psig=1 /xcortree=1859 /SigmaFactorBS="gtatatcatatttcaagggcctttgtttattcatttcttcta cCTTGtggtcaattgctgaAAACTCTATAATAGGCAAAAaccaattgggtgaaacaga t" /listShort="ycgS, ycgR" /listLong="ycgQ" /label="promotor_-10" upshifts complement(334302) /Source="Nicolas_upshifts" /id="U246" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.715284715284715" /psig=1 /xcortree=1859 /SigmaFactorBS="gtatatcatatttcaagggcctttgtttattcatttcttcta cCTTGtggtcaattgctgaAAACTCTATAATAGGCAAAAaccaattgggtgaaacaga t" /listShort="ycgS, ycgR" /listLong="ycgQ" /label="upshifts" promotor_-35 complement(334316..334319) /Source="Nicolas_upshift_promotors" /id="U246" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.715284715284715" /psig=1 /xcortree=1859 /SigmaFactorBS="gtatatcatatttcaagggcctttgtttattcatttcttcta cCTTGtggtcaattgctgaAAACTCTATAATAGGCAAAAaccaattgggtgaaacaga t" /listShort="ycgS, ycgR" /listLong="ycgQ" /label="promotor_-35" misc_feature 334353..334372 /Source="Nicolas_upshift_promotors" /id="U247" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig="0.993006993006993" /xcortree=2116 /SigmaFactorBS="ttcagcaattgaccacaaggtagaagaaatgaataaacaaag gcccttgaaaTATGATATACTTTGTATTGAtattcattctcaattaaaactttgatat a" /listShort="S119, ycgT, S120" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(334353..334371) /Source="Nicolas_upshift_promotors" /id="U248" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=774 /SigmaFactorBS="agccatccgtcctgcctcccgttcacatctatatcaaaGTTT TAattgagaatgaatatCAATACAAAGTATATCATAtttcaagggcctttgtttattc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 334360..334424 /Source="Nicolas_S_feature" /locus_tag="new_352793_352857" /HighExp="B60, Lbexp, LBGexp, dia0, B36, HiOs, GM 15, GM 10, Salt, dia5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S119" upshifts 334361 /Source="Nicolas_upshifts" /id="U247" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig="0.993006993006993" /xcortree=2116 /SigmaFactorBS="ttcagcaattgaccacaaggtagaagaaatgaataaacaaag gcccttgaaaTATGATATACTTTGTATTGAtattcattctcaattaaaactttgatat a" /listShort="S119, ycgT, S120" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(334370) /Source="Nicolas_upshifts" /id="U248" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=774 /SigmaFactorBS="agccatccgtcctgcctcccgttcacatctatatcaaaGTTT TAattgagaatgaatatCAATACAAAGTATATCATAtttcaagggcctttgtttattc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(334387..334392) /Source="Nicolas_upshift_promotors" /id="U248" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=774 /SigmaFactorBS="agccatccgtcctgcctcccgttcacatctatatcaaaGTTT TAattgagaatgaatatCAATACAAAGTATATCATAtttcaagggcctttgtttattc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 334425..335435 /gene="ffoR" /locus_tag="BSU_03270" /old_locus_tag="BSU03270" /EC_number="1.18.1.-" /EC_number="1.8.1.-" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16672620, 25826316" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16672620, 25826316; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Fur-regulated NADPH:ferredoxin oxidoreductase" /protein_id="NP_388209.1" /db_xref="EnsemblGenomes-Gn:BSU03270" /db_xref="EnsemblGenomes-Tr:CAB12121" /db_xref="GOA:O31475" /db_xref="InterPro:IPR000103" /db_xref="InterPro:IPR022890" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG12018" /db_xref="UniProtKB/Swiss-Prot:O31475" /translation="MAENQEVYDVTIIGGGPIGLFTAFYCGMRELKTKVIEFLPKLGG KVSLFFPEKIIRDIGGIPGIAGKQLIEQLKEQAATFDPDIVLNQRVTGFERLDDGTIV LTGSEGKKHYTRTVILACGMGTLEVNEFDSEDAARYAGKNLHYGVEKLDAFKGKRVVI SGGGDTAVDWANELEPIAASVTVVHRREEFGGMESSVTKMKQSSVRVLTPYRLEQLNG DEEGIKSVTVCHTESGQRKDIEIDELIINHGFKIDLGPMMEWGLEIEEGRVKADRHMR TNLPGVFVAGDAAFYESKLRLIAGGFTEGPTAVNSAKAYLDPKAENMAMYSTHHKKLV HK*" /label="ffoR CDS" gene 334425..335435 /gene="ffoR" /locus_tag="BSU_03270" /old_locus_tag="BSU03270" /label="ffoR gene" S_feature 335436..337883 /Source="Nicolas_S_feature" /locus_tag="new_353869_356316" /HighExp="B60, Lbexp, GM 10, GM 25, HiOs, GM 15, dia0, GM 45, LBGexp, H2O2" /AntisenseName="nasF" /AntisenseCor="-0.30348565853404702" /AntisenseRegPval="-6.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S120" CDS complement(335467..336918) /gene="nasF" /locus_tag="BSU_03280" /old_locus_tag="BSU03280" /EC_number="2.1.1.107" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9765565, 10217486, 15028686" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9765565, 10217486, 15028686; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="uroporphyrin-III C-methyltransferase" /protein_id="NP_388210.1" /db_xref="EnsemblGenomes-Gn:BSU03280" /db_xref="EnsemblGenomes-Tr:CAB12122" /db_xref="GOA:P42437" /db_xref="InterPro:IPR000878" /db_xref="InterPro:IPR003043" /db_xref="InterPro:IPR006366" /db_xref="InterPro:IPR012409" /db_xref="InterPro:IPR014776" /db_xref="InterPro:IPR014777" /db_xref="InterPro:IPR035996" /db_xref="InterPro:IPR036108" /db_xref="SubtiList:BG11098" /db_xref="UniProtKB/Swiss-Prot:P42437" /translation="MIMKNGIVYFVGAGPGDPGLLTIKGKQALKEADVILYDRLANPK LLEFASPDCQFIYCGKLPNRHFMKQKEINALLVEKALNGLTVVRLKGGDPSVFGRVGE EADALHEHGIRYEMVPGITSGIAAPLYAGIPVTHRDFASSFAMITAHDKSLKGTPNLD WEGLARSVQTLVFYMGVKNLSYICQQLISYGKSPSVPVIVIQWGTWGRQRSVKGTLEN IQQKVQEHQITNPAIIVIGDIVNFQTHSWFESKPLIGRHLMVVTHGEDEDPLADKLRD SGADLIEWPKWRTENMPVNEEILRKIGTFEDVFFTSRRAVCEFFRALASQKIDIRQLT AKLSAASEQAKTELEKRGFLVTAIQPDSEKRLVVGSRHAVENMQKHESCSFYITHENV IDDRFTHMIQRTISESPLHMVICPNKLSVQQLINGGEQIGILPEPSASRPPIVCIGDD SAAGIYGFTAVQEQDELLAFIHNQHAEKKLLHT*" /label="nasF CDS" gene complement(335467..336918) /gene="nasF" /locus_tag="BSU_03280" /old_locus_tag="BSU03280" /label="nasF gene" downshifts complement(335471) /Source="Nicolas_upshifts" /id="D145" /incds=0 /nref=131 /ntot=230 /MaxReadThrough="1.40657" /MaxDrop="6.58881" /score="10.9556399" /energy="-11.7" /TU="NA" /idTUdmin="U250" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(336979..337299) /gene="nasE" /locus_tag="BSU_03290" /old_locus_tag="BSU03290" /EC_number="1.7.1.4" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10217486, 15028686, 9765565, 22103536" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10217486, 15028686, 9765565, 22103536; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="assimilatory nitrite reductase subunit" /protein_id="NP_388211.1" /db_xref="EnsemblGenomes-Gn:BSU03290" /db_xref="EnsemblGenomes-Tr:CAB12123" /db_xref="GOA:P42436" /db_xref="InterPro:IPR012748" /db_xref="InterPro:IPR017941" /db_xref="InterPro:IPR036922" /db_xref="SubtiList:BG11097" /db_xref="UniProtKB/Swiss-Prot:P42436" /translation="MVNKDVTKVCIGKIEELPEQLGKTVYIEDKELAVFKLSDGSIRA IENRCPHKGGVLAEGIVSGQYVFCPMHDWKISLEDGIVQEPDHGCVKTYETLIEGEHV YLVY*" /label="nasE CDS" gene complement(336979..337299) /gene="nasE" /locus_tag="BSU_03290" /old_locus_tag="BSU03290" /label="nasE gene" promotor_-35 337150..337155 /Source="Nicolas_upshift_promotors" /id="U249" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.00899100899100899" /xcortree=84 /SigmaFactorBS="tgacgatgccttctgccaggacgccgcccttatgCGGACAgc ggttttcaatgGCGCGgatgcttccgtctgaaagcttgaaaaccgcgagctccttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 337169..337173 /Source="Nicolas_upshift_promotors" /id="U249" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.00899100899100899" /xcortree=84 /SigmaFactorBS="tgacgatgccttctgccaggacgccgcccttatgCGGACAgc ggttttcaatgGCGCGgatgcttccgtctgaaagcttgaaaaccgcgagctccttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 337176 /Source="Nicolas_upshifts" /id="U249" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.00899100899100899" /xcortree=84 /SigmaFactorBS="tgacgatgccttctgccaggacgccgcccttatgCGGACAgc ggttttcaatgGCGCGgatgcttccgtctgaaagcttgaaaaccgcgagctccttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(337208) /Source="Nicolas_upshifts" /id="U250" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.853146853146853" /psig="0.957042957042957" /xcortree=1590 /SigmaFactorBS="tcggaaaaattgaagaatTGCCTGAAcaattaggcaaaaCAG TGTATATTGAAGATAAGgagctcgcggttttcaagctttcagacggaagcatccgcgc c" /listShort="nasF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(337210..337229) /Source="Nicolas_upshift_promotors" /id="U250" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.853146853146853" /psig="0.957042957042957" /xcortree=1590 /SigmaFactorBS="tcggaaaaattgaagaatTGCCTGAAcaattaggcaaaaCAG TGTATATTGAAGATAAGgagctcgcggttttcaagctttcagacggaagcatccgcgc c" /listShort="nasF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(337243..337250) /Source="Nicolas_upshift_promotors" /id="U250" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.853146853146853" /psig="0.957042957042957" /xcortree=1590 /SigmaFactorBS="tcggaaaaattgaagaatTGCCTGAAcaattaggcaaaaCAG TGTATATTGAAGATAAGgagctcgcggttttcaagctttcagacggaagcatccgcgc c" /listShort="nasF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(337331..339748) /gene="nasD" /locus_tag="BSU_03300" /old_locus_tag="BSU03300" /EC_number="1.7.1.4" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10972836, 15028686, 9765565, 16428414, 22103536" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10972836, 15028686, 9765565, 16428414, 22103536; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="assimilatory nitrite reductase subunit" /protein_id="NP_388212.1" /db_xref="EnsemblGenomes-Gn:BSU03300" /db_xref="EnsemblGenomes-Tr:CAB12124" /db_xref="GOA:P42435" /db_xref="InterPro:IPR005117" /db_xref="InterPro:IPR006066" /db_xref="InterPro:IPR006067" /db_xref="InterPro:IPR007419" /db_xref="InterPro:IPR012744" /db_xref="InterPro:IPR017121" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036136" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG11096" /db_xref="UniProtKB/Swiss-Prot:P42435" /translation="MGKKQLVLVGNGMAGVRAIEEILSVAKDEFQITIFGAEPHPNYN RILLSKVLQGDTDIKDITLNDWDWYEENNIQLYTNETVIKVDTENKTVITDADRIQPY DELILATGSVPFILPIPGADKKGVTAFRDIKDTDTMLAASKQYKKAAVIGGGLLGLEA ARGLLNLGMDVSVIHLAPFLMERQLDATAGRLLQNELEKQGMTFLLEKQTEEIVGDDR VEGLRFKDGTSIEADLVVMAVGIRPNTTLGAESGIPVNRGIIVNDYMQTEIPHIYAVG ECAEHRGIAYGLVAPLYEQAKVLAKHMCGIETKPYEGSVLSTQLKVSGVEVFSAGDFN ESEEKKAIKVFDEQDGIYKKIVLRGNQIVGAVLFGDSSEGNRLFSMIQKEADISETSK ISILQPLSQEAGTSITAAMSDDEIICGCNGVSKGAIIQAIQEKGCSSTDEIKACTGAS RSCGGCKPLVEEILQHTLGSDFDASAQKEAICGCTTLSRDEVVEEIKAKGLSHTREVM NVLGWKTPEGCSKCRPALNYYLGMINPTKYEDDRTSRFVNERMHANIQKDGTYSVVPR MYGGVTNSTDLRKIADVVDKYEIPLVKMTGGQRIDLIGVKKEDLPKVWEDLDMPSGYA YGKTLRTVKTCVGEQFCRFGTQDSMALGIALEKKFEGLNTPHKVKMAVSACPRNCAES GIKDLGVVGIDGGWELYVGGNGGTHLRAGDLLMKVKTNEEVLEYAGAYLQYYRETANY LERTSAWLERVGLSHVQSVLNDPEKRQELNGRMNETLSVHKDPWKDFLEDKQTSKELF ENVVTTS*" /label="nasD CDS" gene complement(337331..339748) /gene="nasD" /locus_tag="BSU_03300" /old_locus_tag="BSU03300" /label="nasD gene" promotor_-10 complement(339773..339792) /Source="Nicolas_upshift_promotors" /id="U251" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig="0.998001998001998" /xcortree=1620 /SigmaFactorBS="cttttcgtatattttgttacattttataacatgtatcTTAAA TAttcctttttgcTGTGCTACGCTGGAAAAAACatttgataaggagcggatcatctga t" /listShort="nasD, nasE, nasF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(339787) /Source="Nicolas_upshifts" /id="U251" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig="0.998001998001998" /xcortree=1620 /SigmaFactorBS="cttttcgtatattttgttacattttataacatgtatcTTAAA TAttcctttttgcTGTGCTACGCTGGAAAAAACatttgataaggagcggatcatctga t" /listShort="nasD, nasE, nasF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(339804..339810) /Source="Nicolas_upshift_promotors" /id="U251" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig="0.998001998001998" /xcortree=1620 /SigmaFactorBS="cttttcgtatattttgttacattttataacatgtatcTTAAA TAttcctttttgcTGTGCTACGCTGGAAAAAACatttgataaggagcggatcatctga t" /listShort="nasD, nasE, nasF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(339870..342002) /gene="nasC" /locus_tag="BSU_03310" /old_locus_tag="BSU03310" /EC_number="1.7.99.4" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10972836, 15028686, 9765565" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10972836, 15028686, 9765565; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="assimilatory nitrate reductase (catalytic subunit)" /protein_id="NP_388213.2" /db_xref="EnsemblGenomes-Gn:BSU03310" /db_xref="EnsemblGenomes-Tr:CAB12125" /db_xref="GOA:P42434" /db_xref="InterPro:IPR006655" /db_xref="InterPro:IPR006656" /db_xref="InterPro:IPR006657" /db_xref="InterPro:IPR006963" /db_xref="InterPro:IPR009010" /db_xref="InterPro:IPR027467" /db_xref="SubtiList:BG11095" /db_xref="UniProtKB/Swiss-Prot:P42434" /translation="MTERLLRYFRDKQQDVQSEKTYDTQCPFCSMQCKMQLVEQTIVT RKKYTAIGIDNPTTQGRLCIKGMNAHQHALNSSRITRPLLKKNGEFMPVSWEEALNHI KDQVTMIQTEHGHDAMAVYGSASITNEEAYLLGKFARVGLQTKYIDYNGRLCMSAAAT AANQTFGADRGLTNPLSDIPHTRVIILAGTNIAECQPTIMPYFEKAKENGAYFIAIDP RETATTKIADLHLKIKPGTDAALANGLVKIIIDEQLINEDFIQSRTNGFEELKQHTDS LDLNDIAEQTSVSLVDIRKAAVKFAKETSGMLFTARGIEQQTDGTAAVKGFLNMVLIT GKIGKPYSGYGAITGQGNGQGAREHGQKADQLPGYRSIENEEHRAHIAKVWGIHQDEL PRKGVSAYEMMEKINDGDIKGLFLMCSNPAVSSPNANLVKKALRRLTFFVAIDLFISE TAKYADVILPASSYLEDEGTMTNVEGRVTLREASRPCPGEAKHDWQIICDLASALGKG RYFSYTSAEDIFNELREASRGGIADYSGISYGRLRREGGIHWPCPESDHPGTGRLFTE SFAHPDQKAALSVIPNEPPVPKEKPTADYPLYLTTGRVMSHYLTGVQTRKSAALAARH FESFMEIHPQTAATYNIEDRVLVKIESPRGSITVRSKLSEQIRKDTVFVPIHWADAQN VNDLIGEALDPACKMPGFKVCAVRIIPI*" /label="nasC CDS" gene complement(339870..342002) /gene="nasC" /locus_tag="BSU_03310" /old_locus_tag="BSU03310" /label="nasC gene" CDS complement(342009..344324) /gene="nasB" /locus_tag="BSU_03320" /old_locus_tag="BSU03320" /EC_number="1.7.1.3" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7836289, 8799114, 9765565, 10940050, 10972836, 15028686, 24122235" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7836289, 8799114, 9765565, 10940050, 10972836, 15028686, 24122235; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="assimilatory nitrate reductase (electron transfer subunit NasB)" /protein_id="NP_388214.2" /db_xref="EnsemblGenomes-Gn:BSU03320" /db_xref="EnsemblGenomes-Tr:CAB12126" /db_xref="GOA:P42433" /db_xref="InterPro:IPR005117" /db_xref="InterPro:IPR007419" /db_xref="InterPro:IPR012744" /db_xref="InterPro:IPR017121" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036136" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG11094" /db_xref="UniProtKB/Swiss-Prot:P42433" /translation="MKKQRLVLAGNGMAGIRCIEEVLKLNRHMFEIVIFGSEPHPNYN RILLSSVLQGEASLDDITLNSKDWYDKHGITLYTGETVIQIDTDQQQVITDRKRTLSY DKLIVATGSSPHILPIPGADKKGVYGFRTIEDCQALMNMAQHFQKAAVIGAGLLGLEA AVGLQHLGMDVSVIHHSAGIMQKQLDQTAARLLQTELEQKGLTFLLEKDTVSISGATK ADRIHFKDGSSLKADLIVMAAGVKPNIELAVSAGIKVNRGIIVNDFMQTSEPNIYAVG ECAEHNGTVYGLVAPLYEQGKALASHICGVPCEEYQGSAPSAALKIAGIDVWSAGKIQ EDERTTSIKIYDEQAGVYKKALFVDDKLAGVILFGDTRDKQRLLDSLLKQRDISIAKK QIIEPETSGPLFESMPSSETICQCNTVTKGAIEDAVHTNSLTTVEEVKHCTKATGSCG GCKPLVEDLLRYMTNSEYTKPASTPSFCSCTDFTEDDIIAELQRRPFTNPAEVMNQLD WKTKNGCSTCVPAIQYYLEMLYPGFVQPEPATEETCILIPQMYGGRTNAEQLRTIANI IEAYSIPDVSITHGQRLKLSGIKPADLPNMKKDLKMPVYTNEHRHALQSIKACTCGQN RSIQQLAAQIERQLEMLPLPAPISISLSCETDCTEAALQDVGAIRTQAGWDIHIGGVR GTHARSGALFCVTENEDSTAGMIKGLIQYYRETAHYLEGVHQWIDRLGIVHIREVLFE EDLRAQLLESLQTDLSLIQNPTVETGAYKKG*" /label="nasB CDS" gene complement(342009..344324) /gene="nasB" /locus_tag="BSU_03320" /old_locus_tag="BSU03320" /label="nasB gene" promotor_no_box complement(344343..344443) /Source="Nicolas_upshift_promotors" /id="U252" /multdbtbs="SigA" /comp="M21" /sig="Sig-" /pcomp="0.241758241758242" /psig="0.410589410589411" /xcortree=313 /SigmaFactorBS="ttattttctggaaaagacatgtgtaagtttttgtgacacgtt taatgcgttaacaatgcattgtgacataatttttaataggagaaaacttacgagcttc g" /listShort="nasB, nasC, nasD, nasE, nasF" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(344383) /Source="Nicolas_upshifts" /id="U252" /multdbtbs="SigA" /comp="M21" /sig="Sig-" /pcomp="0.241758241758242" /psig="0.410589410589411" /xcortree=313 /SigmaFactorBS="ttattttctggaaaagacatgtgtaagtttttgtgacacgtt taatgcgttaacaatgcattgtgacataatttttaataggagaaaacttacgagcttc g" /listShort="nasB, nasC, nasD, nasE, nasF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 344426..344433 /Source="Nicolas_upshift_promotors" /id="U253" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.613386613386613" /psig="0.928071928071928" /xcortree=319 /SigmaFactorBS="ttaaacgtgtcacaaaaacttacacatGTCTTTTCcagaaaa taatggTCCTATATCCTTGATTCAGAaaatgtaaaataatgagggtctagaaagggga a" /listShort="nasA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 344447..344466 /Source="Nicolas_upshift_promotors" /id="U253" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.613386613386613" /psig="0.928071928071928" /xcortree=319 /SigmaFactorBS="ttaaacgtgtcacaaaaacttacacatGTCTTTTCcagaaaa taatggTCCTATATCCTTGATTCAGAaaatgtaaaataatgagggtctagaaagggga a" /listShort="nasA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 344459 /Source="Nicolas_upshifts" /id="U253" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.613386613386613" /psig="0.928071928071928" /xcortree=319 /SigmaFactorBS="ttaaacgtgtcacaaaaacttacacatGTCTTTTCcagaaaa taatggTCCTATATCCTTGATTCAGAaaatgtaaaataatgagggtctagaaagggga a" /listShort="nasA" /GFF_Attribute="listLong" /label="upshifts" CDS 344504..345709 /gene="nasA" /locus_tag="BSU_03330" /old_locus_tag="BSU03330" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7868621, 12823818, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative nitrate transporter" /protein_id="NP_388215.2" /db_xref="EnsemblGenomes-Gn:BSU03330" /db_xref="EnsemblGenomes-Tr:CAB12127" /db_xref="GOA:P42432" /db_xref="InterPro:IPR004737" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11093" /db_xref="UniProtKB/Swiss-Prot:P42432" /translation="MKLSELKTSGHPLTLLCSFLYFDVSFMIWVMLGALGVYISQDFG LSPFEKGLVVAVPILSGSVFRIILGILTDRIGPKKTAVIGMLVTMIPLLWGTFGGRSL TELYAIGILLGVAGASFAVALPMASRWYPPHLQGLAMGIAGAGNSGTLFATLFGPRLA EQFGWHIVMGIALIPLLIVFILFVSMAKDSPAQPSPQPLKSYLHVFGQKETWFFCLLY SVTFGGFVGLSSFLSIFFVDQYQLSKIHAGDFVTLCVAAGSFFRPVGGLISDRVGGTK VLSVLFVIVALCMAGVSSLPSLSMVIVLLFVGMMGLGMGNGAVFQLVPQRFRKEIGMV TGIVGAAGGIGGFFLPNILGSLKQMTGTYAIGFITFSCIALLAFALVLAAGYYWRKSW SAESSPADV*" /label="nasA CDS" gene 344504..345709 /gene="nasA" /locus_tag="BSU_03330" /old_locus_tag="BSU03330" /label="nasA gene" downshifts 345694 /Source="Nicolas_upshifts" /id="D146" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="2.02479" /MaxDrop="3.6823" /score="39.2612286" /energy="-11.9" /TU="NA" /idTUdmin="U253" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 345753..345759 /Source="Nicolas_upshift_promotors" /id="U254" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.362637362637363" /psig="0.998001998001998" /xcortree=667 /SigmaFactorBS="cacgcgtttgtgcgtgtcttttttattttctCTTGATTttca acagtgaaccGATCAAAATAAATAGTAATTattacgatttgttagtgagaggagtttt c" /listShort="folEB, yciB" /listLong="yczL, yciC" /label="promotor_-35" promotor_-10 345774..345793 /Source="Nicolas_upshift_promotors" /id="U254" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.362637362637363" /psig="0.998001998001998" /xcortree=667 /SigmaFactorBS="cacgcgtttgtgcgtgtcttttttattttctCTTGATTttca acagtgaaccGATCAAAATAAATAGTAATTattacgatttgttagtgagaggagtttt c" /listShort="folEB, yciB" /listLong="yczL, yciC" /label="promotor_-10" upshifts 345782 /Source="Nicolas_upshifts" /id="U254" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.362637362637363" /psig="0.998001998001998" /xcortree=667 /SigmaFactorBS="cacgcgtttgtgcgtgtcttttttattttctCTTGATTttca acagtgaaccGATCAAAATAAATAGTAATTattacgatttgttagtgagaggagtttt c" /listShort="folEB, yciB" /listLong="yczL, yciC" /label="upshifts" CDS 345826..346740 /gene="folEB" /locus_tag="BSU_03340" /old_locus_tag="BSU03340" /EC_number="3.5.4.16" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12426338, 17032654, 19767425" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12426338, 17032654, 19767425; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GTP cyclohydrolase I" /protein_id="NP_388216.2" /db_xref="EnsemblGenomes-Gn:BSU03340" /db_xref="EnsemblGenomes-Tr:CAB12128" /db_xref="GOA:P94398" /db_xref="InterPro:IPR003801" /db_xref="InterPro:IPR022838" /db_xref="SubtiList:BG12019" /db_xref="UniProtKB/Swiss-Prot:P94398" /translation="MNQHTLLPKKTERLQYFGSVSPIKGEKPVEKEKMKDLQNIRKDY FFDIQHVGVANVSHPVTITSAMMPAEQTTAANFTMTCNLPRNQKGINMSRLTELLQVY HQNGWILSFSSLQQFTKELAENMDTSSATVEVRFPWFFERKSPKLEKAGLMHADIFMS VTYRKDQPFKQRAGISAKVTTLCPCSKEISEYSAHNQRGTVSIWADIHPAASLPSDVK ADLLHAAESNASARLHPVLKRPDEKAVTETAYENPRFVEDLARLIAADLFELEWVSAF EIECRNEESIHLHDAYAKLCFSKEVDKI*" /label="folEB CDS" gene 345826..346740 /gene="folEB" /locus_tag="BSU_03340" /old_locus_tag="BSU03340" /label="folEB gene" CDS 346737..347321 /gene="yciB" /locus_tag="BSU_03350" /old_locus_tag="BSU03350" /function="16.1: Circulate" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12426338, 20013255; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative Zn(2+)-dependent division lipoprotein (schizosome)" /protein_id="NP_388217.2" /db_xref="EnsemblGenomes-Gn:BSU03350" /db_xref="EnsemblGenomes-Tr:CAB12129" /db_xref="GOA:C0SP99" /db_xref="InterPro:IPR005490" /db_xref="SubtiList:BG12020" /db_xref="UniProtKB/Swiss-Prot:C0SP99" /translation="MKLSLFIIAVLMPVILLSACSDHAEEHASINTKKTVENITDVRK TAKTSIDWTKPSGGEYPDIKQKHVWIDVNVKEQKAYIKEGSNTIYTMMISSGLDQTKD DATPKGTFYVEPERGEWFFSEGYQEGAEYWVSWKNHGEFLFHSVPMTKDQKVIKTEAE KLGTKASHGCIRLTIPDAKWVYENIPEHTKVVIS*" /label="yciB CDS" gene 346737..347321 /gene="yciB" /locus_tag="BSU_03350" /old_locus_tag="BSU03350" /label="yciB gene" promotor_-35 347332..347339 /Source="Nicolas_upshift_promotors" /id="U255" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=668 /SigmaFactorBS="aaaagtggtgatcagctgaattgaaaaccGTTGACAAaaagg aaaaaagaCCATACAATTTAAATCGTAAcaattacgttttatgataaatggcttatca t" /listShort="yczL, yciC, S121" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 347353..347372 /Source="Nicolas_upshift_promotors" /id="U255" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=668 /SigmaFactorBS="aaaagtggtgatcagctgaattgaaaaccGTTGACAAaaagg aaaaaagaCCATACAATTTAAATCGTAAcaattacgttttatgataaatggcttatca t" /listShort="yczL, yciC, S121" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 347363 /Source="Nicolas_upshifts" /id="U255" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=668 /SigmaFactorBS="aaaagtggtgatcagctgaattgaaaaccGTTGACAAaaagg aaaaaagaCCATACAATTTAAATCGTAAcaattacgttttatgataaatggcttatca t" /listShort="yczL, yciC, S121" /GFF_Attribute="listLong" /label="upshifts" CDS 347417..347602 /gene="yczL" /locus_tag="BSU_03359" /old_locus_tag="BSU03359" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097674.1" /db_xref="EnsemblGenomes-Gn:BSU03359" /db_xref="EnsemblGenomes-Tr:CAX52544" /db_xref="UniProtKB/Swiss-Prot:C0H3U7" /translation="MKSGKASIKDLAVGKGKDLRWGKGLNAVGVFTDLEIGRQREMSA KSCSTPLYIRRSIQFKS*" /label="yczL CDS" gene 347417..347602 /gene="yczL" /locus_tag="BSU_03359" /old_locus_tag="BSU03359" /label="yczL gene" CDS 347630..348823 /gene="zinU" /locus_tag="BSU_03360" /old_locus_tag="BSU03360" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:2013568, 9811636, 12426338, 18344368, 19648245, 27060116, 27561249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2013568, 9811636, 12426338, 18344368, 19648245, 27060116, 27561249; Product type t: transporter" /codon_start=1 /transl_table=11 /product="zinc metallochaperone with NTPase activity" /protein_id="NP_388218.1" /db_xref="EnsemblGenomes-Gn:BSU03360" /db_xref="EnsemblGenomes-Tr:CAB12130" /db_xref="GOA:P94400" /db_xref="InterPro:IPR003495" /db_xref="InterPro:IPR011629" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036627" /db_xref="SubtiList:BG12021" /db_xref="UniProtKB/Swiss-Prot:P94400" /translation="MKKIPVTVLSGYLGAGKTTLLNSILQNREGLKIAVIVNDMSEVN IDAGLVKQEGGLSRTDEKLVEMSNGCICCTLREDLLIEVEKLAKDGRFDYIVIESTGI SEPIPVAQTFSYIDEEMGIDLTKFCQLDTMVTVVDANRFWHDYQSGESLLDRKEALGE KDEREIADLLIDQIEFCDVLILNKCDLVSEQELEQLENVLRKLQPRARFIRSVKGNVK PQEILHTGLFNFEEASGSAGWIQELTAGHAEHTPETEEYGISSFVYKRRLPFHSTRFY RWLDQMPKNVVRAKGIVWCASHNNLALLMSQAGPSVTIEPVSYWVAALPKLEQEQVKQ QEPEILEEWDPEFGDRLTQLVFIGTDLDEETITKELDQCLLTEYEFDSDWSLFEDPFK WKLNQ*" /label="zinU CDS" gene 347630..348823 /gene="zinU" /locus_tag="BSU_03360" /old_locus_tag="BSU03360" /label="zinU gene" downshifts 348815 /Source="Nicolas_upshifts" /id="D147" /incds=0 /nref=26 /ntot=45 /MaxReadThrough="5.12378" /MaxDrop="5.8275" /score="15.6427627" /energy="-9.2" /TU="U255" /idTUdmin="U255" /TUdmin="-792" /isTUend="FALSE" /label="downshifts" S_feature 348860..350529 /Source="Nicolas_S_feature" /locus_tag="new_367293_368962" /HighExp="Etha, B60, Cold, Heat, B36, C30, BMM, S6, C90, S2" /AntisenseName="yckB" /AntisenseCor="-0.170121935628575" /AntisenseRegPval="-2.2999999999999998" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S121" CDS complement(348872..349552) /gene="yckA" /locus_tag="BSU_03370" /old_locus_tag="BSU03370" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15849754, 16850406, 23038252; Product type t: transporter" /codon_start=1 /transl_table=11 /product="aminoacid ABC transporter (permease subunit)" /protein_id="NP_388219.1" /db_xref="EnsemblGenomes-Gn:BSU03370" /db_xref="EnsemblGenomes-Tr:CAB12131" /db_xref="GOA:P42399" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11177" /db_xref="UniProtKB/Swiss-Prot:P42399" /translation="MINSIQWEYIFNTKLAIESFPYVIKGIGYTLLISFVSMFAGTVI GLFISLARMSKLALLRWPAKLYISFMRGVPILVILFILYFGFPYIGIEFSAVTAALIG FSLNSAAYIAEINRSAISSVEKGQWEAASSLGLSYWQTMRGIILPQSIRIALPPLANV LLDLIKASSLAAMITVPELLQHAKIIGGREFDYMTMYILTALIYWAICSIAAVFQNIL EKKYAHYV*" /label="yckA CDS" gene complement(348872..349552) /gene="yckA" /locus_tag="BSU_03370" /old_locus_tag="BSU03370" /label="yckA gene" downshifts complement(348878) /Source="Nicolas_upshifts" /id="D148" /incds=0 /nref=101 /ntot=231 /MaxReadThrough="0.41655" /MaxDrop="6.18136" /score="40.1548023" /energy="-12.6" /TU="NA" /idTUdmin="U256" /TUdmin="-9" /isTUend="TRUE" /label="downshifts" CDS complement(349562..350425) /gene="yckB" /locus_tag="BSU_03380" /old_locus_tag="BSU03380" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:23038252" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23038252; Product type t: transporter" /codon_start=1 /transl_table=11 /product="amino acid ABC transporter (binding lipoprotein subunit)" /protein_id="NP_388220.1" /db_xref="EnsemblGenomes-Gn:BSU03380" /db_xref="EnsemblGenomes-Tr:CAB12132" /db_xref="GOA:P42400" /db_xref="InterPro:IPR001638" /db_xref="InterPro:IPR018313" /db_xref="PDB:2IEE" /db_xref="SubtiList:BG11178" /db_xref="UniProtKB/Swiss-Prot:P42400" /translation="MKSFMHSKAVIFSFTMAFFLILAACSGKNEADSKDTGWEQIKDK GKIVVATSGTLYPTSYHDTDSGSDKLTGYEVEVVREAAKRLGLKVEFKEMGIDGMLTA VNSGQVDAAANDIDVTKDREEKFAFSTPYKYSYGTAIVRKDDLSGIKTLKDLKGKKAA GAATTVYMEVARKYGAKEVIYDNATNEQYLKDVANGRTDVILNDYYLQTLALAAFPDL NITIHPDIKYMPNKQALVMKKSNAALQKKMNEALKEMSKDGSLTKLSKQFFNKADVSK KIDADVQDVDL*" /label="yckB CDS" gene complement(349562..350425) /gene="yckB" /locus_tag="BSU_03380" /old_locus_tag="BSU03380" /label="yckB gene" promotor_-10 complement(350447..350466) /Source="Nicolas_upshift_promotors" /id="U256" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.791208791208791" /psig="0.983016983016983" /xcortree=1804 /SigmaFactorBS="caattcgaactttttgaaaacgcgatcaacaTATTGCAAccc cttatgttcaaTGCTATCTTTTTAGTTGATTaacagattgggggaactataggtgaaa t" /listShort="yckB, yckA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(350459) /Source="Nicolas_upshifts" /id="U256" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.791208791208791" /psig="0.983016983016983" /xcortree=1804 /SigmaFactorBS="caattcgaactttttgaaaacgcgatcaacaTATTGCAAccc cttatgttcaaTGCTATCTTTTTAGTTGATTaacagattgggggaactataggtgaaa t" /listShort="yckB, yckA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(350461..353295) /Source="Nicolas_S_feature" /locus_tag="new_368894_371728_c" /HighExp="GM 150, T-4.40H, G/S, Pyr, S2, C30, T-5.40H, C90, T-3.40H, T0.30H" /AntisenseName="bglC" /AntisenseCor="-0.37749573319969598" /AntisenseRegPval="-9.8000000000000007" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, Sig-" /TUshortPSig="0.248, 0.994, 0.0879" /TUlongSig="SigD" /TUlongPSig=1 /label="S122" promotor_-35 complement(350481..350488) /Source="Nicolas_upshift_promotors" /id="U256" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.791208791208791" /psig="0.983016983016983" /xcortree=1804 /SigmaFactorBS="caattcgaactttttgaaaacgcgatcaacaTATTGCAAccc cttatgttcaaTGCTATCTTTTTAGTTGATTaacagattgggggaactataggtgaaa t" /listShort="yckB, yckA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 350498..350504 /Source="Nicolas_upshift_promotors" /id="U257" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=154 /SigmaFactorBS="acataaggggttgcaatatgttgatcgCGTTTTCaaaaagtt cgaattGTGTATACAAAAAGCATGGgtgggtgtttaaaagcgtctatgaagggaagag g" /listShort="S123, yckC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 350519..350537 /Source="Nicolas_upshift_promotors" /id="U257" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=154 /SigmaFactorBS="acataaggggttgcaatatgttgatcgCGTTTTCaaaaagtt cgaattGTGTATACAAAAAGCATGGgtgggtgtttaaaagcgtctatgaagggaagag g" /listShort="S123, yckC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 350531..350753 /Source="Nicolas_S_feature" /locus_tag="new_368964_369186" /HighExp="Etha, Salt, B60, Sw, B36, Gly, Heat, S6, Cold, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99896700000000005" /TUshortSig="SigB" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S123" upshifts 350531 /Source="Nicolas_upshifts" /id="U257" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=154 /SigmaFactorBS="acataaggggttgcaatatgttgatcgCGTTTTCaaaaagtt cgaattGTGTATACAAAAAGCATGGgtgggtgtttaaaagcgtctatgaagggaagag g" /listShort="S123, yckC" /GFF_Attribute="listLong" /label="upshifts" CDS 350587..350784 /locus_tag="BSU_03385" /old_locus_tag="BSU03385" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513942.1" /translation="MSKDECQTYQGNACESEGCSRPVTHLCQYRKKWSRGMKPIFRIN LSLADAPKAYDIFDEKENGNI*" /label="hypothetical protein CDS" gene 350587..350784 /locus_tag="BSU_03385" /old_locus_tag="BSU03385" /label="gene" promotor_-35 350722..350727 /Source="Nicolas_upshift_promotors" /id="U258" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=779 /SigmaFactorBS="atgaaaccgatcttcagaataaatttaAGTCTTgctgatgcc cctaagGCATATGATATATTCGATGagaaagaaaatggaaacatttaaaccataatgg g" /listShort="yckC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 350743..350761 /Source="Nicolas_upshift_promotors" /id="U258" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=779 /SigmaFactorBS="atgaaaccgatcttcagaataaatttaAGTCTTgctgatgcc cctaagGCATATGATATATTCGATGagaaagaaaatggaaacatttaaaccataatgg g" /listShort="yckC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 350755 /Source="Nicolas_upshifts" /id="U258" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=779 /SigmaFactorBS="atgaaaccgatcttcagaataaatttaAGTCTTgctgatgcc cctaagGCATATGATATATTCGATGagaaagaaaatggaaacatttaaaccataatgg g" /listShort="yckC" /GFF_Attribute="listLong" /label="upshifts" CDS 350803..351258 /gene="yckC" /locus_tag="BSU_03390" /old_locus_tag="BSU03390" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406; Product type m:membrane component" /codon_start=1 /transl_table=11 /product="conserved integral membrane protein of unknown function" /protein_id="NP_388221.1" /db_xref="EnsemblGenomes-Gn:BSU03390" /db_xref="EnsemblGenomes-Tr:CAB12133" /db_xref="GOA:P42401" /db_xref="InterPro:IPR010432" /db_xref="SubtiList:BG11179" /db_xref="UniProtKB/Swiss-Prot:P42401" /translation="MNIYKPAGFWIRLGAALLDYIIVSVPLLLIYWLITGKDPNDSMF ISLVVLLYSILLPMFWRGYLIGKRICGIRIVKKDGSQVSLLTMFLRVIVAGLVYCITF GLGLIASLILIAVREDKRTLHDLIAGTYVTYATPGEEELNADEEIRKSE*" /label="yckC CDS" gene 350803..351258 /gene="yckC" /locus_tag="BSU_03390" /old_locus_tag="BSU03390" /label="yckC gene" downshifts 351233 /Source="Nicolas_upshifts" /id="D149" /incds=0 /nref=40 /ntot=193 /MaxReadThrough="1.14817" /MaxDrop="5.48303" /score="23.1539807" /energy="-9.8" /TU="NA" /idTUdmin="U257" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 351281..351287 /Source="Nicolas_upshift_promotors" /id="U259" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=899 /SigmaFactorBS="cgaagagattagaaagagcgaataatggttcgctctttttat ttttaTGCATAAaaaatacaaggcaGCAAAACATATGaaaaataggattggaggaata a" /listShort="yckD" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 351294 /Source="Nicolas_upshifts" /id="U259" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=899 /SigmaFactorBS="cgaagagattagaaagagcgaataatggttcgctctttttat ttttaTGCATAAaaaatacaaggcaGCAAAACATATGaaaaataggattggaggaata a" /listShort="yckD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 351301..351312 /Source="Nicolas_upshift_promotors" /id="U259" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=899 /SigmaFactorBS="cgaagagattagaaagagcgaataatggttcgctctttttat ttttaTGCATAAaaaatacaaggcaGCAAAACATATGaaaaataggattggaggaata a" /listShort="yckD" /GFF_Attribute="listLong" /label="promotor_-10" CDS 351340..351672 /gene="yckD" /locus_tag="BSU_03400" /old_locus_tag="BSU03400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_388222.1" /db_xref="EnsemblGenomes-Gn:BSU03400" /db_xref="EnsemblGenomes-Tr:CAB12134" /db_xref="InterPro:IPR024485" /db_xref="SubtiList:BG11180" /db_xref="UniProtKB/Swiss-Prot:P42402" /translation="MKRITINIITMFIAAAVISLTGTAEAAEKQQQSPANVTLTDQQK KEIEQLEAEILKKRKDVISKYVQYGILPKERGEHIKNHLDKHFEMMKQNGFVPKHHPH PHKFEKRH*" /label="yckD CDS" gene 351340..351672 /gene="yckD" /locus_tag="BSU_03400" /old_locus_tag="BSU03400" /label="yckD gene" downshifts 351653 /Source="Nicolas_upshifts" /id="D150" /incds=0 /nref=20 /ntot=44 /MaxReadThrough="2.48743" /MaxDrop="4.3022" /score="-1.40416926" /energy="-11.8" /TU="NA" /idTUdmin="U259" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 351758..351765 /Source="Nicolas_upshift_promotors" /id="U260" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.936063936063936" /psig="0.953046953046953" /xcortree=1581 /SigmaFactorBS="caatattagctgagctgttccgcgactaacatcGAGTTGATa tgaaacgcgtttcaTAGCCTATGATAGGTTTATCaaataattcaggagtgataaacac t" /listShort="bglC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 351781..351800 /Source="Nicolas_upshift_promotors" /id="U260" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.936063936063936" /psig="0.953046953046953" /xcortree=1581 /SigmaFactorBS="caatattagctgagctgttccgcgactaacatcGAGTTGATa tgaaacgcgtttcaTAGCCTATGATAGGTTTATCaaataattcaggagtgataaacac t" /listShort="bglC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 351785 /Source="Nicolas_upshifts" /id="U260" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.936063936063936" /psig="0.953046953046953" /xcortree=1581 /SigmaFactorBS="caatattagctgagctgttccgcgactaacatcGAGTTGATa tgaaacgcgtttcaTAGCCTATGATAGGTTTATCaaataattcaggagtgataaacac t" /listShort="bglC" /GFF_Attribute="listLong" /label="upshifts" CDS 351826..353259 /gene="bglC" /locus_tag="BSU_03410" /old_locus_tag="BSU03410" /EC_number="3.2.1.86" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14652714, 15139916, 18069788" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14652714, 15139916, 18069788; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aryl-phospho-beta-d-glucosidase" /protein_id="NP_388223.1" /db_xref="EnsemblGenomes-Gn:BSU03410" /db_xref="EnsemblGenomes-Tr:CAB12135" /db_xref="GOA:P42403" /db_xref="InterPro:IPR001360" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR018120" /db_xref="InterPro:IPR033132" /db_xref="SubtiList:BG11181" /db_xref="UniProtKB/Swiss-Prot:P42403" /translation="MIHQHPESFPKHFLWGSASAAYQIEGAWNEDGKGPSVWDVFTKI PGKTFKGTNGEIAVDHYHRFKEDVALMAEMGLKAYRFSVSWPRVFPKGKGEINEAGLA FYDSLIDELLSHHIEPVLTLYHWDLPQALMDEYGGFESRNIIEDFNHYCITLYKRFGD RVKYWVTLNEQNYNFNHGFITAMHPPGVKDRKRFYEANHIAFLANAKAIESFREYVPE GKIGPSFAYSPAYPLSSHPEDILAFENAEEFTNNWWLDMYCWGTYPQIPFRCLEKQGW APTIEAGDMDLLAKGKPDFVGVNYYQTITYERNPLDGVSEGKMNTTGQKGTNQETGIP GVFKTKKNPHLTTSNWDWTIDPIGLRIGLRRITSRYQLPVFITENGLGEFDKVEDGTV QDDYRIDYLRSHLEQCRQAISDGVDLIGYCSWSFTDLLSWLNGYQKRYGFVYVNRDEE STSDLKRLKKKSFYWYQDVIKTNGESL*" /label="bglC CDS" gene 351826..353259 /gene="bglC" /locus_tag="BSU_03410" /old_locus_tag="BSU03410" /label="bglC gene" downshifts 353237 /Source="Nicolas_upshifts" /id="D151" /incds=0 /nref=12 /ntot=61 /MaxReadThrough="1.51167" /MaxDrop="4.6748" /score="18.0928088" /energy="-15.9" /TU="NA" /idTUdmin="U260" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(353296..353694) /gene="nin" /locus_tag="BSU_03420" /old_locus_tag="BSU03420" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11359569, 11814663, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11359569, 11814663, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="inhibitor of the DNA degrading activity of NucA (competence)" /protein_id="NP_388224.1" /db_xref="EnsemblGenomes-Gn:BSU03420" /db_xref="EnsemblGenomes-Tr:CAB12136" /db_xref="GOA:P12669" /db_xref="InterPro:IPR020354" /db_xref="PDB:4MQD" /db_xref="SubtiList:BG10839" /db_xref="UniProtKB/Swiss-Prot:P12669" /translation="MIKSWKPQELSISYHQFTVFQKDSTPPVMDWTDEAIEKGYAAAD GAISFEAQRNTKAFILFRLNSSETVNSYEKKVTVPFHVTENGIHIESIMSKRLSFDLP KGDYQLTCWTVPAEMSDLHADTYIIDAVSV*" /label="nin CDS" gene complement(353296..353694) /gene="nin" /locus_tag="BSU_03420" /old_locus_tag="BSU03420" /label="nin gene" promotor_no_box complement(353691..353791) /Source="Nicolas_upshift_promotors" /id="U261" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.234765234765235" /psig="0.247752247752248" /xcortree=1715 /SigmaFactorBS="caggctcttgggtcgggcatcggcttaccgattacccagacg gcacaaaggttttattcacaattcagtaaacagtacatagaggaggaacagcacattg a" /listShort="nin, S122" /GFF_Attribute="listLong" /label="promotor_no_box" CDS complement(353721..354170) /gene="nucA" /locus_tag="BSU_03430" /old_locus_tag="BSU03430" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:2841296, 7746143, 11359569, 11814663" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2841296, 7746143, 11359569, 11814663; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endonuclease" /protein_id="NP_388225.3" /db_xref="EnsemblGenomes-Gn:BSU03430" /db_xref="EnsemblGenomes-Tr:CAB12137" /db_xref="GOA:P12667" /db_xref="InterPro:IPR029476" /db_xref="SubtiList:BG10838" /db_xref="UniProtKB/Swiss-Prot:P12667" /translation="MNITTDIIKTILLVIVIIAAAAVGLIKGDFFSADQKTSQTKEYD ETMAFPSDRYPETAKHIKDAINEGHSEVCTIDRDGAEERREQSLKDVPSKKGYDRDEW PMAMCKEGGEGASVEYISPADNRGAGSWVGHRLTDYPDGTKVLFTIQ*" /label="nucA CDS" gene complement(353721..354170) /gene="nucA" /locus_tag="BSU_03430" /old_locus_tag="BSU03430" /label="nucA gene" upshifts complement(353731) /Source="Nicolas_upshifts" /id="U261" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.234765234765235" /psig="0.247752247752248" /xcortree=1715 /SigmaFactorBS="caggctcttgggtcgggcatcggcttaccgattacccagacg gcacaaaggttttattcacaattcagtaaacagtacatagaggaggaacagcacattg a" /listShort="nin, S122" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(354185..354204) /Source="Nicolas_upshift_promotors" /id="U262" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.994005994005994" /xcortree=2957 /SigmaFactorBS="taaactgatcgtaaaacataaaatttaaACCTTTACaccaaa tgctttcTGGATTACTCTTGTGTCAGTtttaaaagcgggaggtgaacatcacgacgga c" /listShort="nucA, nin, S122, yckB, yckA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(354193) /Source="Nicolas_upshifts" /id="U262" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.994005994005994" /xcortree=2957 /SigmaFactorBS="taaactgatcgtaaaacataaaatttaaACCTTTACaccaaa tgctttcTGGATTACTCTTGTGTCAGTtttaaaagcgggaggtgaacatcacgacgga c" /listShort="nucA, nin, S122, yckB, yckA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(354195..354337) /Source="Nicolas_S_feature" /locus_tag="new_372628_372770_c" /HighExp="C30, Diami, M40t45, Cold, Lbstat, T0.30H, M0t90, dia15, C90, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigD" /TUshortPSig="0.0879, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S124" promotor_-35 complement(354218..354225) /Source="Nicolas_upshift_promotors" /id="U262" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.994005994005994" /xcortree=2957 /SigmaFactorBS="taaactgatcgtaaaacataaaatttaaACCTTTACaccaaa tgctttcTGGATTACTCTTGTGTCAGTtttaaaagcgggaggtgaacatcacgacgga c" /listShort="nucA, nin, S122, yckB, yckA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(354338..356059) /gene="tlpC" /locus_tag="BSU_03440" /old_locus_tag="BSU03440" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7704255, 7921238, 15187186, 27899502" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7704255, 7921238, 15187186, 27899502; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="methyl-accepting chemotaxis protein (plant colonization)" /protein_id="NP_388226.2" /db_xref="EnsemblGenomes-Gn:BSU03440" /db_xref="EnsemblGenomes-Tr:CAB12138" /db_xref="GOA:P39209" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR004090" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033463" /db_xref="SubtiList:BG10790" /db_xref="UniProtKB/Swiss-Prot:P39209" /translation="MLIKRFKMKLGTKILCLVFVVILLFSASVGTVMLKEITESMKQM ATEKAKGDLALSSTYIDDVMSGDWQVKNNKLYKGQTQINGNEDIVDLLGEKTGDTITI FQGDTRVATNVMKNGERAVGTQASSEVIAAVLKKGKRFYGQADVAGSSYQTAYMPLKD QNGNIIGMLYTGANQSILASLTQSLFTQFAIVLVIVIMVSVILVLVFTRKINKRLNAL KSAFESAGNGDMTIEVSDKTGDELSELSVYYNKMRMKLNDTIQTVQQSALQLASASQQ LSAGAEETNQASEKITEAVQQIANGAQDQITRIENSESSLKQASADIRDISANTAAIA DKGQLAQSKADIGQKEIANVQAQMDAIHQSIQKSGEIIHQLDGRSKQIEQILSVITQI ADQTNLLALNAAIEAARAGEQGKGFAVVADEVRKLAEESQQSAGQISKLIIEIQKDMN RSARSVEHVKTEAAEGVTMIQRTRDAFKEIAAATGEISAEISDLSASVTNISASAHQI NDSFAANTADIKESTKNTRQAAALTEEQFAAMEEITAASETLSQLAEELTGIISQFKM INQAENG*" /label="tlpC CDS" gene complement(354338..356059) /gene="tlpC" /locus_tag="BSU_03440" /old_locus_tag="BSU03440" /label="tlpC gene" promotor_-35 354350..354357 /Source="Nicolas_upshift_promotors" /id="U263" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig="0.996003996003996" /xcortree=2959 /SigmaFactorBS="ttgccaatttacaataatgatagtaagtcatcagccgttttc GGCTTGATtaatcattttaaatTGGCTTATGATACCGGTAAGctcctcagctaattga g" /listShort="S125, hxlR" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 354368..357511 /Source="Nicolas_S_feature" /locus_tag="new_372801_375944" /HighExp="T1.0H, T1.30H, T0.30H, T2.0H, T2.30H, T3.0H, T3.30H, T4.0H, T0.0H, T-0.40H" /AntisenseName="tlpC" /AntisenseCor="-0.40398083053643302" /AntisenseRegPval="-11.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S125" upshifts 354368 /Source="Nicolas_upshifts" /id="U263" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig="0.996003996003996" /xcortree=2959 /SigmaFactorBS="ttgccaatttacaataatgatagtaagtcatcagccgttttc GGCTTGATtaatcattttaaatTGGCTTATGATACCGGTAAGctcctcagctaattga g" /listShort="S125, hxlR" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 354372..354391 /Source="Nicolas_upshift_promotors" /id="U263" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig="0.996003996003996" /xcortree=2959 /SigmaFactorBS="ttgccaatttacaataatgatagtaagtcatcagccgttttc GGCTTGATtaatcattttaaatTGGCTTATGATACCGGTAAGctcctcagctaattga g" /listShort="S125, hxlR" /GFF_Attribute="listLong" /label="promotor_-10" promotor_no_box complement(354373..354473) /Source="Nicolas_upshift_promotors" /id="U264" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.452547452547453" /psig="0.0879120879120879" /xcortree=2190 /SigmaFactorBS="ggctgcattaacagaggagcaatttgctgcaatggaggagat taccgcagcttctgaaacactttctcaattagctgaggagcttaccggtatcataagc c" /listShort="S124, nucA, nin, S122" /listLong="yckB, yckA" /label="promotor_no_box" upshifts complement(354413) /Source="Nicolas_upshifts" /id="U264" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.452547452547453" /psig="0.0879120879120879" /xcortree=2190 /SigmaFactorBS="ggctgcattaacagaggagcaatttgctgcaatggaggagat taccgcagcttctgaaacactttctcaattagctgaggagcttaccggtatcataagc c" /listShort="S124, nucA, nin, S122" /listLong="yckB, yckA" /label="upshifts" promotor_-10 complement(356083..356101) /Source="Nicolas_upshift_promotors" /id="U265" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2796 /SigmaFactorBS="cggcctgaagatcaggccggttttattttttctaaaATAAAA CTttaaacccaaaaaCCCGATAAGTAATATGACCtgcaaatcgtaaagggaggaatta t" /listShort="tlpC, S124, nucA, nin" /listLong="S122" /label="promotor_-10" upshifts complement(356098) /Source="Nicolas_upshifts" /id="U265" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2796 /SigmaFactorBS="cggcctgaagatcaggccggttttattttttctaaaATAAAA CTttaaacccaaaaaCCCGATAAGTAATATGACCtgcaaatcgtaaagggaggaatta t" /listShort="tlpC, S124, nucA, nin" /listLong="S122" /label="upshifts" promotor_-35 complement(356115..356122) /Source="Nicolas_upshift_promotors" /id="U265" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2796 /SigmaFactorBS="cggcctgaagatcaggccggttttattttttctaaaATAAAA CTttaaacccaaaaaCCCGATAAGTAATATGACCtgcaaatcgtaaagggaggaatta t" /listShort="tlpC, S124, nucA, nin" /listLong="S122" /label="promotor_-35" CDS complement(356170..356727) /gene="hxlB" /locus_tag="BSU_03450" /old_locus_tag="BSU03450" /EC_number="5.3.1.27" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10572115, 15978081" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10572115, 15978081; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="6-phospho-3-hexuloisomerase (PHI)" /protein_id="NP_388227.1" /db_xref="EnsemblGenomes-Gn:BSU03450" /db_xref="EnsemblGenomes-Tr:CAB12139" /db_xref="GOA:P42404" /db_xref="InterPro:IPR001347" /db_xref="InterPro:IPR017552" /db_xref="PDB:1M3S" /db_xref="PDB:1VIV" /db_xref="SubtiList:BG11182" /db_xref="UniProtKB/Swiss-Prot:P42404" /translation="MKTTEYVAEILNELHNSAAYISNEEADQLADHILSSHQIFTAGA GRSGLMAKSFAMRLMHMGFNAHIVGEILTPPLAEGDLVIIGSGSGETKSLIHTAAKAK SLHGIVAALTINPESSIGKQADLIIRMPGSPKDQSNGSYKTIQPMGSLFEQTLLLFYD AVILKLMEKKGLDSETMFTHHANLE*" /label="hxlB CDS" gene complement(356170..356727) /gene="hxlB" /locus_tag="BSU_03450" /old_locus_tag="BSU03450" /label="hxlB gene" downshifts complement(356173) /Source="Nicolas_upshifts" /id="D152" /incds=0 /nref=51 /ntot=130 /MaxReadThrough="1.98332" /MaxDrop="6.56052" /score="42.3682356" /energy="-15.4" /TU="NA" /idTUdmin="U266" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(356733..357365) /gene="hxlA" /locus_tag="BSU_03460" /old_locus_tag="BSU03460" /EC_number="4.1.2.43" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10572115, 15978081" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10572115, 15978081; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-hexulose-6-phosphate synthase (HPS)" /protein_id="NP_388228.1" /db_xref="EnsemblGenomes-Gn:BSU03460" /db_xref="EnsemblGenomes-Tr:CAB12140" /db_xref="GOA:P42405" /db_xref="InterPro:IPR001754" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR017553" /db_xref="SubtiList:BG11183" /db_xref="UniProtKB/Swiss-Prot:P42405" /translation="MELQLALDLVNIPEAIELVKEVEQYIDVVEIGTPVVINEGLRAV KEIKEAFPQLKVLADLKIMDAGGYEIMKASEAGADIITVLGATDDATIKGAVEEAKKQ KKKILVDMINVKDIESRAKEIDALGVDYICVHTGYDLQAEGKNSFEELTTIKNTVKNA KTAIAGGIKLDTLPEVIQQKPDLVIVGGGITSAADKAETASKMKQLIVQG*" /label="hxlA CDS" gene complement(356733..357365) /gene="hxlA" /locus_tag="BSU_03460" /old_locus_tag="BSU03460" /label="hxlA gene" promotor_-10 complement(357391..357410) /Source="Nicolas_upshift_promotors" /id="U266" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.658341658341658" /psig="0.987012987012987" /xcortree=1517 /SigmaFactorBS="agtatcctccaagtaacttgttgacttcaaagtgcctaCTTC tcaacaaaagaaggAACCTATAGAATGAACAATAattcgaaaaagggagtggatcaac a" /listShort="hxlA, hxlB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(357406) /Source="Nicolas_upshifts" /id="U266" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.658341658341658" /psig="0.987012987012987" /xcortree=1517 /SigmaFactorBS="agtatcctccaagtaacttgttgacttcaaagtgcctaCTTC tcaacaaaagaaggAACCTATAGAATGAACAATAattcgaaaaagggagtggatcaac a" /listShort="hxlA, hxlB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(357425..357428) /Source="Nicolas_upshift_promotors" /id="U266" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.658341658341658" /psig="0.987012987012987" /xcortree=1517 /SigmaFactorBS="agtatcctccaagtaacttgttgacttcaaagtgcctaCTTC tcaacaaaagaaggAACCTATAGAATGAACAATAattcgaaaaagggagtggatcaac a" /listShort="hxlA, hxlB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 357489..357492 /Source="Nicolas_upshift_promotors" /id="U267" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.536463536463537" /psig=1 /xcortree=1957 /SigmaFactorBS="acttggaggatactgtgaggagagacaatcagatttCTTTcg cttgattttatgAGTGAGTATAATGAAAAAAGagtctgcaaaaaagtaagtaagtgat g" /listShort="hxlR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 357507..357526 /Source="Nicolas_upshift_promotors" /id="U267" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.536463536463537" /psig=1 /xcortree=1957 /SigmaFactorBS="acttggaggatactgtgaggagagacaatcagatttCTTTcg cttgattttatgAGTGAGTATAATGAAAAAAGagtctgcaaaaaagtaagtaagtgat g" /listShort="hxlR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 357513 /Source="Nicolas_upshifts" /id="U267" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.536463536463537" /psig=1 /xcortree=1957 /SigmaFactorBS="acttggaggatactgtgaggagagacaatcagatttCTTTcg cttgattttatgAGTGAGTATAATGAAAAAAGagtctgcaaaaaagtaagtaagtgat g" /listShort="hxlR" /GFF_Attribute="listLong" /label="upshifts" CDS 357599..357961 /gene="hxlR" /locus_tag="BSU_03470" /old_locus_tag="BSU03470" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15978081, 26973631" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15978081, 26973631; Product type r: regulator" /codon_start=1 /transl_table=11 /product="positive regulator of hxlAB expression (formaldehyde sensing)" /protein_id="NP_388229.2" /db_xref="EnsemblGenomes-Gn:BSU03470" /db_xref="EnsemblGenomes-Tr:CAB12141" /db_xref="GOA:P42406" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11184" /db_xref="UniProtKB/Swiss-Prot:P42406" /translation="MSRMDDKRFNCEKELTLAVIGGKWKMLILWHLGKEGTKRFNELK TLIPDITQKILVNQLRELEQDMIVHREVYPVVPPKVEYSLTPHGESLMPILEAMYEWG KGYMELIDIDKNVMKESL*" /label="hxlR CDS" gene 357599..357961 /gene="hxlR" /locus_tag="BSU_03470" /old_locus_tag="BSU03470" /label="hxlR gene" downshifts 357945 /Source="Nicolas_upshifts" /id="D153" /incds=0 /nref=14 /ntot=154 /MaxReadThrough="3.13609" /MaxDrop="3.66949" /score="20.4643411" /energy="-9.6" /TU="U267" /idTUdmin="U263" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 358208..358211 /Source="Nicolas_upshift_promotors" /id="U268" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.658341658341658" /psig="0.994005994005994" /xcortree=3241 /SigmaFactorBS="cggcatcccgcatgaaacttttcacccatttttcGGTGataa aaacatttttTTCATTTAAACTGAACGGTAgaaagataaaaaatattgaaaacaatga a" /listShort="S126, srfAA, srfAB, comS, srfAC, srfAD, ycxA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 358226..358245 /Source="Nicolas_upshift_promotors" /id="U268" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.658341658341658" /psig="0.994005994005994" /xcortree=3241 /SigmaFactorBS="cggcatcccgcatgaaacttttcacccatttttcGGTGataa aaacatttttTTCATTTAAACTGAACGGTAgaaagataaaaaatattgaaaacaatga a" /listShort="S126, srfAA, srfAB, comS, srfAC, srfAD, ycxA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 358234..358534 /Source="Nicolas_S_feature" /locus_tag="new_376667_376967" /HighExp="HiOs, T-1.10H, T5.0H, T4.0H, T-1.40H, S2, M9-stat, T3.30H, T0.0H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.20585600000000001" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S126" upshifts 358234 /Source="Nicolas_upshifts" /id="U268" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.658341658341658" /psig="0.994005994005994" /xcortree=3241 /SigmaFactorBS="cggcatcccgcatgaaacttttcacccatttttcGGTGataa aaacatttttTTCATTTAAACTGAACGGTAgaaagataaaaaatattgaaaacaatga a" /listShort="S126, srfAA, srfAB, comS, srfAC, srfAD, ycxA" /GFF_Attribute="listLong" /label="upshifts" CDS 358535..369298 /gene="srfAA" /locus_tag="BSU_03480" /old_locus_tag="BSU03480" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15066026, 16166527, 8288534, 8441623, 14762003, 16707694, 26284661, 26268540, 14762003" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15066026, 16166527, 8288534, 8441623, 14762003, 16707694, 26284661, 26268540, 14762003; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="surfactin synthetase" /protein_id="NP_388230.2" /db_xref="EnsemblGenomes-Gn:BSU03480" /db_xref="EnsemblGenomes-Tr:CAB12142" /db_xref="GOA:P27206" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR001242" /db_xref="InterPro:IPR006162" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR010060" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR013321" /db_xref="InterPro:IPR020806" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="InterPro:IPR036736" /db_xref="SubtiList:BG10168" /db_xref="UniProtKB/Swiss-Prot:P27206" /translation="MEITFYPLTDAQKRIWYTEKFYPHTSISNLAGIGKLVSADAIDY VLVEQAIQEFIRRNDAMRLRLRLDENGEPVQYISEYRPVDIKHTDTTEDPNAIEFISQ WSREETKKPLPLYDCDLFRFSLFTIKENEVWFYANVHHVISDGISMNILGNAIMHIYL ELASGSETKEGISHSFIDHVLSEQEYAQSKRFEKDKAFWNKQFESVPELVSLKRNASA GGSLDAERFSKDVPEALHQQILSFCEANKVSVLSVFQSLLAAYLYRVSGQNDVVTGTF MGNRTNAKEKQMLGMFVSTVPLRTNIDGGQAFSEFVKDRMKDLMKTLRHQKYPYNLLI NDLRETKSSLTKLFTVSLEYQVMQWQKEEDLAFLTEPIFSGSGLNDVSIHVKDRWDTG KLTIDFDYRTDLFSREEINMICERMITMLENALTHPEHTIDELTLISDAEKEKLLARA GGKSVSYRKDMTIPELFQEKAELLSDHPAVVFEDRTLSYRTLHEQSARIANVLKQKGV GPDSPVAVLIERSERMITAIMGILKAGGAYVPIDPGFPAERIQYILEDCGADFILTES KVAAPEADAELIDLDQAIEEGAEESLNADVNARNLAYIIYTSGTTGRPKGVMIEHRQV HHLVESLQQTIYQSGSQTLRMALLAPFHFDASVKQIFASLLLGQTLYIVPKKTVTNGA ALTAYYRKNSIEATDGTPAHLQMLAAAGDFEGLKLKHMLIGGEGLSSVVADKLLKLFK EAGTAPRLTNVYGPTETCVDASVHPVIPENAVQSAYVPIGKALGNNRLYILDQKGRLQ PEGVAGELYIAGDGVGRGYLHLPELTEEKFLQDPFVPGDRMYRTGDVVRWLPDGTIEY LGREDDQVKVRGYRIELGEIEAVIQQAPDVAKAVVLARPDEQGNLEVCAYVVQKPGSE FAPAGLREHAARQLPDYMVPAYFTEVTEIPLTPSGKVDRRKLFALEVKAVSGTAYTAP RNETEKAIAAIWQDVLNVEKAGIFDNFFETGGHSLKAMTLLTKIHKETGIEIPLQFLF EHPTITALAEEADHRESKAFAVIEPAEKQEHYPLSLAQQRTYIVSQFEDAGVGYNMPA AAILEGPLDIQKLERAFQGLIRRHESLRTSFVLENSTPRQKIHDSVDFNIEMIERGGR SDEAIMASFVRTFDLAKAPLFRIGLLGLEENRHMLLFDMHHLISDGVSIGIMLEELAR IYKGEQLPDLRLQYKDYAVWQSRQAAEGYKKDQAYWKEVFAGELPVLQLLSDYPRPPV QSFEGDRVSIKLDAGVKDRLNRLAEQNGATLYMVMLSAYYTLLSKYTGQDDIIVGTPS AGRNHSDTEGIIGMFVNTLAIRSEVKQNETFTQLISRVRKRVLDAFSHQDYPFEWLVE DLNIPRDVSRHPLFDTMFSLQNATEGIPAVGDLSLSVQETNFKIAKFDLTVQARETDE GIEIDVDYSTKLFKQSTADRLLTHFARLLEDAAADPEKPISEYKLLSEEEAASQIQQF NPGRTPYPKDKTIVQLFEEQAANTPDHTALQYEGESLTYRELNERANRLARGILSLGA GEGRTAAVLCERSMDMIVSILAVLKSGSAYVPIDPEHPIQRMQHFFRDSGAKVLLTQR KLKALAEEAEFKGVIVLADEEESYHADARNLALPLDSAAMANLTYTSGTTGTPKGNIV THANILRTVKETNYLSITEQDTILGLSNYVFDAFMFDMFGSLLNGAKLVLIPKETVLD MARLSRVIERENISILMITTALFHLLVDLNPACLSTLRKIMFGGERASVEHVRKALQT VGKGKLLHMYGPSESTVFATYHPVDELEEHTLSVPIGKPVSNTEVYILDRTGHVQPAG IAGELCVSGEGLVKGYYNRPELTEEKFVPHPFTSGERMYKTGDLARWLPNGDIEFIGR IDHQVKIRGQRIELGEIEHQLQTHDRVQESVVLAVDQGAGDKLLCAYYVGEGDISSQE MREHAAKDLPAYMVPAVFIQMDELPLTGNGKIDRRALPIPDANVSRGVSYVAPRNGTE QKVADIWAQVLQAEQVGAYDHFFDIGGHSLAGMKMLALVHQELGVELSLKDLFQSPTV EGLAQVIASAEKGTAASISPAEKQDTYPVSSPQKRMYVLQQLEDAQTSYNMPAVLRLT GELDVERLNSVMQQLMQRHEALRTTFEIKDGETVQRIWEEAECEIAYFEAPEEETERI VSEFIKPFKIDQLPLFRIGLIKHSDTEHVLLFDMHHIISDGASVGVLIEELSKLYDGE TLEPLRIQYKDYAVWQQQFIQSELYKKQEEHWLKELDGELPVLTLPTDYSRPAVQTFE GDRIAFSLEAGKADALRRLAKETDSTLYMVLLASYSAFLSKISGQDDIIVGSPVAGRS QADVSRVIGMFVNTLALRTYPKGEKTFADYLNEVKETALSAFDAQDYPLEDLIGNVQV QRDTSRNPLFDAVFSMQNANIKDLTMKGIQLEPHPFERKTAKFDLTLTADETDGGLTF VLEYNTALFKQETIERWKQYWMELLDAVTGNPNQPLSSLSLVTETEKQALLEAWKGKA LPVPTDKTVHQLFEETAQRHKDRPAVTYNGQSWTYGELNAKANRLARILMDCGISPDD RVGVLTKPSLEMSAAVLGVLKAGAAFVPIDPDYPDQRIEYILQDSGAKLLLKQEGISV PDSYTGDVILLDGSRTILSLPLDENDEENPETAVTAENLAYMIYTSGTTGQPKGVMVE HHALVNLCFWHHDAFSMTAEDRSAKYAGFGFDASIWEMFPTWTIGAELHVIEEAIRLD IVRLNDYFETNGVTITFLPTQLAEQFMELENTSLRVLLTGGDKLKRAVKKPYTLVNNY GPTENTVVATSAEIHPEEGSLSIGRAIANTRVYILGEGNQVQPEGVAGELCVAGRGLA RGYLNREDETAKRFVADPFVPGERMYRTGDLVKWTGGGIEYIGRIDQQVKVRGYRIEL SEIEVQLAQLSEVQDAAVTAVKDKGGNTAIAAYVTPESADIEALKSALKETLPDYMIP AFWVTLNELPVTANGKVDRKALPEPDIEAGSGEYKAPTTDMEELLAGIWQDVLGMSEV GVTDNFFSLGGDSIKGIQMASRLNQHGWKLEMKDLFQHPTIEELTQYVERAEGKQADQ GPVEGEVILTPIQRWFFEKNFTNKHHWNQSVMLHAKKGFDPERVEKTLQALIEHHDAL RMVYREGQEDVIQYNRGLEAASAQLEVIQIEGQAADYEDRIEREAERLQSSIDLQEGG LLKAGLFQAEDGDHLLLAIHHLVVDGVSWRILLEDFAAVYTQLEQGNEPVLPQKTHSF AEYAERLQDFANSKAFLKEKEYWRQLEEQAVAAKLPKDRESGDQRMKHTKTIEFSLTA EETEQLTTKVHEAYHTEMNDILLTAFGLAMKEWTGQDRVSVHLEGHGREEIIEDLTIS RTVGWFTSMYPMVLDMKHADDLGYQLKQMKEDIRHVPNKGVGYGILRYLTAPEHKEDV AFSIQPDVSFNYLGQFDEMSDAGLFTRSELPSGQSLSPETEKPNALDVVGYIENGKLT MSLAYHSLEFHEKTVQTFSDSFKAHLLRIIEHCLSQDGTELTPSDLGDDDLTLDELDK LMEIF*" /label="srfAA CDS" gene 358535..369298 /gene="srfAA" /locus_tag="BSU_03480" /old_locus_tag="BSU03480" /label="srfAA gene" CDS 369311..380062 /gene="srfAB" /locus_tag="BSU_03490" /old_locus_tag="BSU03490" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15066026, 16166527, 16553878, 17227471, 14762003, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15066026, 16166527, 16553878, 17227471, 14762003, 26284661; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="surfactin synthetase" /protein_id="NP_388231.2" /db_xref="EnsemblGenomes-Gn:BSU03490" /db_xref="EnsemblGenomes-Tr:CAB12143" /db_xref="GOA:Q04747" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR001242" /db_xref="InterPro:IPR006162" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR010060" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR020806" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="InterPro:IPR036736" /db_xref="SubtiList:BG10169" /db_xref="UniProtKB/Swiss-Prot:Q04747" /translation="MSKKSIQKVYALTPMQEGMLYHAMLDPHSSSYFTQLELGIHGAF DLEIFEKSVNELIRSYDILRTVFVHQQLQKPRQVVLAERKTKVHYEDISHADENRQKE HIERYKQDVQRQGFNLAKDILFKVAVFRLAADQLYLVWSNHHIMMDGWSMGVLMKSLF QNYEALRAGRTPANGQGKPYSDYIKWLGKQDNEEAESYWSERLAGFEQPSVLPGRLPV KKDEYVNKEYSFTWDETLVARIQQTANLHQVTGPNLFQAVWGIVLSKYNFTDDVIFGT VVSGRPSEINGIETMAGLFINTIPVRVKVERDAAFADIFTAVQQHAVEAERYDYVPLY EIQKRSALDGNLLNHLVAFENYPLDQELENGSMEDRLGFSIKVESAFEQTSFDFNLIV YPGKTWTVKIKYNGAAFDSAFIERTAEHLTRMMEAAVDQPAAFVREYGLVGDEEQRQI VEVFNSTKAELPEGMAVHQVFEEQAKRTPASTAVVYEGTKLTYRELNAAANRLARKLV EHGLQKGETAAIMNDRSVETVVGMLAVLKAGAAYVPLDPALPGDRLRFMAEDSSVRMV LIGNSYTGQAHQLQVPVLTLDIGFEESEAADNLNLPSAPSDLAYIMYTSGSTGKPKGV MIEHKSILRLVKNAGYVPVTEEDRMAQTGAVSFDAGTFEVFGALLNGAALYPVKKETL LDAKQFAAFLREQSITTMWLTSPLFNQLAAKDAGMFGTLRHLIIGGDALVPHIVSKVK QASPSLSLWNGYGPTENTTFSTSFLIDREYGGSIPIGKPIGNSTAYIMDEQQCLQPIG APGELCVGGIGVARGYVNLPELTEKQFLEDPFRPGERIYRTGDLARWLPDGNIEFLGR IDNQVKVRGFRIELGEIETKLNMAEHVTEAAVIIRKNKADENEICAYFTADREVAVSE LRKTLSQSLPDYMVPAHLIQMDSLPLTPNGKINKKELPAPQSEAVQPEYAAPKTESEK KLAEIWEGILGVKAGVTDNFFMIGGHSLKAMMMTAKIQEHFHKEVPIKVLFEKPTIQE LALYLEENESKEEQTFEPIRQASYQQHYPVSPAQRRMYILNQLGQANTSYNVPAVLLL EGEVDKDRLENAIQQLINRHEILRTSFDMIDGEVVQTVHKNISFQLEAAKGREEDAEE IIKAFVQPFELNRAPLVRSKLVQLEEKRHLLLIDMHHIITDGSSTGILIGDLAKIYQG ADLELPQIHYKDYAVWHKEQTNYQKDEEYWLDVFKGELPILDLPADFERPAERSFAGE RVMFGLDKQITAQIKSLMAETDTTMYMFLLAAFNVLLSKYASQDDIIVGSPTAGRTHP DLQGVPGMFVNTVALRTAPAGDKTFAQFLEEVKTASLQAFEHQSYPLEELIEKLPLTR DTSRSPLFSVMFNMQNMEIPSLRLGDLKISSYSMLHHVAKFDLSLEAVEREEDIGLSF DYATALFKDETIRRWSRHFVNIIKAAAANPNVRLSDVDLLSSAETAALLEERHMTQIT EATFAALFEKQAQQTPDHSAVKAGGNLLTYRELDEQANQLAHHLRAQGAGNEDIVAIV MDRSAEVMVSILGVMKAGAAFLPIDPDTPEERIRYSLEDSGAKFAVVNERNMTAIGQY EGIIVSLDDGKWRNESKERPSSISGSRNLAYVIYTSGTTGKPKGVQIEHRNLTNYVSW FSEEAGLTENDKTVLLSSYAFDLGYTSMFPVLLGGGELHIVQKETYTAPDEIAHYIKE HGITYIKLTPSLFHTIVNTASFAKDANFESLRLIVLGGEKIIPTDVIAFRKMYGHTEF INHYGPTEATIGAIAGRVDLYEPDAFAKRPTIGRPIANAGALVLNEALKLVPPGASGQ LYITGQGLARGYLNRPQLTAERFVENPYSPGSLMYKTGDVVRRLSDGTLAFIGRADDQ VKIRGYRIEPKEIETVMLSLSGIQEAVVLAVSEGGLQELCAYYTSDQDIEKAELRYQL SLTLPSHMIPAFFVQVDAIPLTANGKTDRNALPKPNAAQSGGKALAAPETALEESLCR IWQKTLGIEAIGIDDNFFDLGGHSLKGMMLIANIQAELEKSVPLKALFEQPTVRQLAA YMEASAVSGGHQVLKPADKQDMYPLSSAQKRMYVLNQLDRQTISYNMPSVLLMEGELD ISRLRDSLNQLVNRHESLRTSFMEANGEPVQRIIEKAEVDLHVFEAKEDEADQKIKEF IRPFDLNDAPLIRAALLRIEAKKHLLLLDMHHIIADGVSRGIFVKELALLYKGEQLPE PTLHYKDFAVWQNEAEQKERMKEHEAYWMSVLSGELPELDLPLDYARPPVQSFKGDTI RFRTGSETAKAVEKLLAETGTTLHMVLHAVFHVFLSKISGQRDIVIGSVTAGRTNADV QDMPGMFVNTLALRMEAKEQQTFAELLELAKQTNLSALEHQEYPFEDLVNQLDLPRDM SRNPLFNVMVTTENPDKEQLTLQNLSISPYEAHQGTSKFDLTLGGFTDENGIGLQLEY ATDLFAKETAEKWSEYVLRLLKAVADNPNQPLSSLLLVTETEKQALLEAWKGKALPVP TDKTVHQLFEETVQRHKDRPAVTYNGQSWTYGELNAKANRLARILMDCGISPDDRVGV LTKPSLEMSAAVLGVLKAGAAFVPIDPDYPDQRIEYILQDSGAKLLLKQEGISVPDSY TGDVILLDGSRTILSLPLDENDEGNPETAVTAENLAYMIYTSGTTGQPKGVMVEHHAL VNLCFWHHDAFSMTAEDRSAKYAGFGFDASIWEMFPTWTIGAELHVIDEAIRLDIVRL NDYFETNGVTITFLPTQLAEQFMELENTSLRVLLTGGDKLKRAVKKPYTLVNNYGPTE NTVVATSAEIHPEEGSLSIGRAIANTRVYILGEGNQVQPEGVAGELCVAGRGLARGYL NREDETAKRFVADPFVPGERMYRTGDLVKWVNGGIEYIGRIDQQVKVRGYRIELSEIE VQLAQLSEVQDAAVTAVKDKGGNTAIAAYVTPETADIEALKSTLKETLPDYMIPAFWV TLNELPVTANGKVDRKALPEPDIEAGSGEYKAPTTDMEELLAGIWQDVLGMSEVGVTD NFFSLGGDSIKGIQMASRLNQHGWKLEMKDLFQHPTIEELTQYVERAEGKQADQGPVE GEVILTPIQRWFFEKNFTNKHHWNQSVMLHAKKGFDPERVEKTLQALIEHHDALRMVY REENGDIVQVYKPIGESKVSFEIVDLYGSDEEMLRSQIKLLANKLQSSLDLRNGPLLK AEQYRTEAGDHLLIAVHHLVVDGVSWRILLEDFASGYMQAEKEESLVFPQKTNSFKDW AEELAAFSQSAHLLQQAEYWSQIAAEQVSPLPKDCETEQRIVKDTSSVLCELTAEDTK HLLTDVHQPYGTEINDILLSALGLTMKEWTKGAKIGINLEGHGREDIIPNVNISRTVG WFTAQYPVVLDISDADASAVIKTVKENLRRIPDKGVGYGILRYFTETAETKGFTPEIS FNYLGQFDSEVKTDFFEPSAFDMGRQVSGESEALYALSFSGMIRNGRFVLSCSYNEKE FERATVEEQMERFKENLLMLIRHCTEKEDKEFTPSDFSAEDLEMDEMGDIFDMLEENL K*" /label="srfAB CDS" gene 369311..380062 /gene="srfAB" /locus_tag="BSU_03490" /old_locus_tag="BSU03490" /label="srfAB gene" CDS 372447..372587 /gene="comS" /locus_tag="BSU_03500" /old_locus_tag="BSU03500" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10361283, 16554821, 8752331, 9696775, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10361283, 16554821, 8752331, 9696775, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of genetic competence" /protein_id="NP_388232.1" /db_xref="EnsemblGenomes-Gn:BSU03500" /db_xref="EnsemblGenomes-Tr:CAB12144" /db_xref="GOA:P80355" /db_xref="InterPro:IPR035139" /db_xref="SubtiList:BG11045" /db_xref="UniProtKB/Swiss-Prot:P80355" /translation="MNRSGKHLISSIILYPRPSGECISSISLDKQTQATTSPLYFCWR EK*" /label="comS CDS" gene 372447..372587 /gene="comS" /locus_tag="BSU_03500" /old_locus_tag="BSU03500" /label="comS gene" CDS 380099..383926 /gene="srfAC" /locus_tag="BSU_03510" /old_locus_tag="BSU03510" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15066026, 16166527, 16553878, 17227471, 14762003, 22720735, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15066026, 16166527, 16553878, 17227471, 14762003, 22720735, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="surfactin synthetase" /protein_id="NP_388233.2" /db_xref="EnsemblGenomes-Gn:BSU03510" /db_xref="EnsemblGenomes-Tr:CAB12145" /db_xref="GOA:Q08787" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR001031" /db_xref="InterPro:IPR001242" /db_xref="InterPro:IPR006162" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR020806" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="InterPro:IPR029058" /db_xref="InterPro:IPR036736" /db_xref="PDB:1JMK" /db_xref="PDB:2VSQ" /db_xref="SubtiList:BG10170" /db_xref="UniProtKB/Swiss-Prot:Q08787" /translation="MSQFSKDQVQDMYYLSPMQEGMLFHAILNPGQSFYLEQITMKVK GSLNIKCLEESMNVIMDRYDVFRTVFIHEKVKRPVQVVLKKRQFHIEEIDLTHLTGSE QTAKINEYKEQDKIRGFDLTRDIPMRAAIFKKAEESFEWVWSYHHIILDGWCFGIVVQ DLFKVYNALREQKPYSLPPVKPYKDYIKWLEKQDKQASLRYWREYLEGFEGQTTFAEQ RKKQKDGYEPKELLFSLSEAETKAFTELAKSQHTTLSTALQAVWSVLISRYQQSGDLA FGTVVSGRPAEIKGVEHMVGLFINVVPRRVKLSEGITFNGLLKRLQEQSLQSEPHQYV PLYDIQSQADQPKLIDHIIVFENYPLQDAKNEESSENGFDMVDVHVFEKSNYDLNLMA SPGDEMLIKLAYNENVFDEAFILRLKSQLLTAIQQLIQNPDQPVSTINLVDDREREFL LTGLNPPAQAHETKPLTYWFKEAVNANPDAPALTYSGQTLSYRELDEEANRIARRLQK HGAGKGSVVALYTKRSLELVIGILGVLKAGAAYLPVDPKLPEDRISYMLADSAAACLL THQEMKEQAAELPYTGTTLFIDDQTRFEEQASDPATAIDPNDPAYIMYTSGTTGKPKG NITTHANIQGLVKHVDYMAFSDQDTFLSVSNYAFDAFTFDFYASMLNAARLIIADEHT LLDTERLTDLILQENVNVMFATTALFNLLTDAGEDWMKGLRCILFGGERASVPHVRKA LRIMGPGKLINCYGPTEGTVFATAHVVHDLPDSISSLPIGKPISNASVYILNEQSQLQ PFGAVGELCISGMGVSKGYVNRADLTKEKFIENPFKPGETLYRTGDLARWLPDGTIEY AGRIDDQVKIRGHRIELEEIEKQLQEYPGVKDAVVVADRHESGDASINAYLVNRTQLS AEDVKAHLKKQLPAYMVPQTFTFLDELPLTTNGKVNKRLLPKPDQDQLAEEWIGPRNE MEETIAQIWSEVLGRKQIGIHDDFFALGGHSLKAMTAASRIKKELGIDLPVKLLFEAP TIAGISAYLKNGGSDGLQDVTIMNQDQEQIIFAFPPVLGYGLMYQNLSSRLPSYKLCA FDFIEEEDRLDRYADLIQKLQPEGPLTLFGYSAGCSLAFEAAKKLEEQGRIVQRIIMV DSYKKQGVSDLDGRTVESDVEALMNVNRDNEALNSEAVKHGLKQKTHAFYSYYVNLIS TGQVKADIDLLTSGADFDMPEWLASWEEATTGVYRVKRGFGTHAEMLQGETLDRNAEI LLEFLNTQTVTVS*" /label="srfAC CDS" gene 380099..383926 /gene="srfAC" /locus_tag="BSU_03510" /old_locus_tag="BSU03510" /label="srfAC gene" CDS 383955..384683 /gene="srfAD" /locus_tag="BSU_03520" /old_locus_tag="BSU03520" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16166527, 16553878, 17227471, 14762003, 22720735, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16166527, 16553878, 17227471, 14762003, 22720735, 26284661; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="surfactin synthetase" /protein_id="NP_388234.1" /db_xref="EnsemblGenomes-Gn:BSU03520" /db_xref="EnsemblGenomes-Tr:CAB12146" /db_xref="GOA:Q08788" /db_xref="InterPro:IPR001031" /db_xref="InterPro:IPR012223" /db_xref="InterPro:IPR029058" /db_xref="PDB:2K2Q" /db_xref="PDB:2RON" /db_xref="SubtiList:BG10171" /db_xref="UniProtKB/Swiss-Prot:Q08788" /translation="MSQLFKSFDASEKTQLICFPFAGGYSASFRPLHAFLQGECEMLA AEPPGHGTNQTSAIEDLEELTDLYKQELNLRPDRPFVLFGHSMGGMITFRLAQKLERE GIFPQAVIISAIQPPHIQRKKVSHLPDDQFLDHIIQLGGMPAELVENKEVMSFFLPSF RSDYRALEQFELYDLAQIQSPVHVFNGLDDKKCIRDAEGWKKWAKDITFHQFDGGHMF LLSQTEEVAERIFAILNQHPIIQP*" /label="srfAD CDS" gene 383955..384683 /gene="srfAD" /locus_tag="BSU_03520" /old_locus_tag="BSU03520" /label="srfAD gene" downshifts 384665 /Source="Nicolas_upshifts" /id="D154" /incds=0 /nref=196 /ntot=261 /MaxReadThrough="4.65721" /MaxDrop="6.48992" /score="24.9581454" /energy="-11.1" /TU="U268" /idTUdmin="U268" /TUdmin="-1339" /isTUend="FALSE" /label="downshifts" promotor_-35 384721..384728 /Source="Nicolas_upshift_promotors" /id="U269" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.795204795204795" /psig=1 /xcortree=2955 /SigmaFactorBS="cattcaaccgtgatcaaaagcggacagcttcggctgttccgc tttttttgTGTTGAATgccaatttctgCATGGTATAATAGTCGAAATactcaaataaa g" /listShort="ycxA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 384731 /Source="Nicolas_upshifts" /id="U269" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.795204795204795" /psig=1 /xcortree=2955 /SigmaFactorBS="cattcaaccgtgatcaaaagcggacagcttcggctgttccgc tttttttgTGTTGAATgccaatttctgCATGGTATAATAGTCGAAATactcaaataaa g" /listShort="ycxA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 384740..384759 /Source="Nicolas_upshift_promotors" /id="U269" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.795204795204795" /psig=1 /xcortree=2955 /SigmaFactorBS="cattcaaccgtgatcaaaagcggacagcttcggctgttccgc tttttttgTGTTGAATgccaatttctgCATGGTATAATAGTCGAAATactcaaataaa g" /listShort="ycxA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 384784..386010 /gene="srfT" /locus_tag="BSU_03530" /old_locus_tag="BSU03530" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 15849754, 16850406, 25366377; Product type t: transporter" /codon_start=1 /transl_table=11 /product="surfactin exporter" /protein_id="NP_388235.2" /db_xref="EnsemblGenomes-Gn:BSU03530" /db_xref="EnsemblGenomes-Tr:CAB12147" /db_xref="GOA:Q08791" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10172" /db_xref="UniProtKB/Swiss-Prot:Q08791" /translation="MRTSPRMKWFVLLFTFVFAIGMNSFRNSFQFFMLPMADAFHADR SLISVSVSIFMITTGIVQFFVGFFIDRFSVRKIMALGAVCISASFLVLPYSPNVHVFS AIYGVLGGIGYSCAVGVTTQYFISCWFDTHKGLALAILTNANSAGLLLLSPIWAAAPY HAGWQSTYTILGIVMAAVLLPLLVFGMKHPPHAQAETVKKSYDWRGFWNVMKQSRLIH ILYFGVFTCGFTMGIIDAHLVPILKDAHVSHVNGMMAAFGAFIIIGGLLAGWLSDLLG SRSVMLSILFFIRLLSLICLLIPILGIHHSDLWYFGFILLFGLSYTGVIPLTAASISE SYQTGLIGSLLGINFFIHQVAGALSVYAGGLFFDMTHGYLLIVAVCIVFVGLSAVIEL VPFLDKQKAKETHHSI*" /label="srfT CDS" gene 384784..386010 /gene="srfT" /locus_tag="BSU_03530" /old_locus_tag="BSU03530" /label="srfT gene" downshifts 386004 /Source="Nicolas_upshifts" /id="D155" /incds=0 /nref=15 /ntot=198 /MaxReadThrough="2.67601" /MaxDrop="4.06773" /score="7.33278866" /energy="-13.2" /TU="NA" /idTUdmin="U268" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(386025..386582) /gene="ycxB" /locus_tag="BSU_03540" /old_locus_tag="BSU03540" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 21965396" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388236.1" /db_xref="EnsemblGenomes-Gn:BSU03540" /db_xref="EnsemblGenomes-Tr:CAB12148" /db_xref="GOA:Q08793" /db_xref="InterPro:IPR025588" /db_xref="SubtiList:BG10173" /db_xref="UniProtKB/Swiss-Prot:Q08793" /translation="MIQYASESINLPGEITFKDVREIFFYQIAKISCFYFLLFCAIFA AVNFINGWPRIVYGSDALNLFMNSMLIIVMSVLFTLLLLLLLYVKFSRAYKKNERMKS KRTYTLNQEGIRICSKKYDLIFNWDEITAVFEYKNIFRVNTSSGQYIAIPKHFFHSEE EMNRFKEIILKNTETKKLKFKKDQH*" /label="ycxB CDS" gene complement(386025..386582) /gene="ycxB" /locus_tag="BSU_03540" /old_locus_tag="BSU03540" /label="ycxB gene" promotor_no_box complement(386040..386140) /Source="Nicolas_upshift_promotors" /id="U270" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.725274725274725" /psig="0.024975024975025" /xcortree=283 /SigmaFactorBS="atattgcgatccccaaacatttttttcactccgaagaggaga tgaacagattcaaggagattatccttaaaaataccgaaacaaaaaaactcaaatttaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" downshifts complement(386062) /Source="Nicolas_upshifts" /id="D156" /incds=0 /nref=46 /ntot=241 /MaxReadThrough="0.9216" /MaxDrop="4.25654" /score="8.42655219" /energy="-14.3" /TU="U270" /idTUdmin="U271" /TUdmin=18 /isTUend="TRUE" /label="downshifts" upshifts complement(386080) /Source="Nicolas_upshifts" /id="U270" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.725274725274725" /psig="0.024975024975025" /xcortree=283 /SigmaFactorBS="atattgcgatccccaaacatttttttcactccgaagaggaga tgaacagattcaaggagattatccttaaaaataccgaaacaaaaaaactcaaatttaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(386611..386630) /Source="Nicolas_upshift_promotors" /id="U271" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=3105 /SigmaFactorBS="aaaaaacaaagcgccctggtatgcctgcaaaaaaatgagaaa tTATGCTAGACTAAAAGGAAAaacatggttagaggtgtaggtttaccgtatgattcaa t" /listShort="ycxB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(386613) /Source="Nicolas_upshifts" /id="U271" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=3105 /SigmaFactorBS="aaaaaacaaagcgccctggtatgcctgcaaaaaaatgagaaa tTATGCTAGACTAAAAGGAAAaacatggttagaggtgtaggtttaccgtatgattcaa t" /listShort="ycxB" /GFF_Attribute="listLong" /label="upshifts" CDS complement(386636..387574) /gene="ycxC" /locus_tag="BSU_03550" /old_locus_tag="BSU03550" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388237.2" /db_xref="EnsemblGenomes-Gn:BSU03550" /db_xref="EnsemblGenomes-Tr:CAB12149" /db_xref="GOA:Q08794" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG10174" /db_xref="UniProtKB/Swiss-Prot:Q08794" /translation="MVKHQQTPAYIAAILYSFIIGLSFLFVKIALQTAEPFDILAHRF TIAFAAATVPILFGWVKLSIRVKDVIDILPLALLYPALFFSFQAFGLVYSSSSEAGII QAAIPIFTMVFAAYVLKERPTWTQKGFTVLSVAGVMFIFVMKGVDVESASLKGSLLIL LSALSSAMYNTAARKMTQRFKLTELTYIMSAIGFVVFNAIALVRHGAAGTVGTYFLPF REPGFVLAIVYLGVLSSLVTSFLSNYTLSRIEAFKMSAFNHVSTIVTMIAGFVILNES LAWYHLAGAVCIMIGVVGSNINLEKKTKRPGMPAKK*" /label="ycxC CDS" gene complement(386636..387574) /gene="ycxC" /locus_tag="BSU_03550" /old_locus_tag="BSU03550" /label="ycxC gene" promotor_-10 complement(387613..387631) /Source="Nicolas_upshift_promotors" /id="U272" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.536463536463537" /psig="0.536463536463537" /xcortree=793 /SigmaFactorBS="tgtaccggtacagttcattgtttttctcATTGTAccgttctg accgcggCCATACAATAAAGGGAGCGaccggcgctgcaattcaggtaaaggagccctt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(387620) /Source="Nicolas_upshifts" /id="U272" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.536463536463537" /psig="0.536463536463537" /xcortree=793 /SigmaFactorBS="tgtaccggtacagttcattgtttttctcATTGTAccgttctg accgcggCCATACAATAAAGGGAGCGaccggcgctgcaattcaggtaaaggagccctt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(387647..387652) /Source="Nicolas_upshift_promotors" /id="U272" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.536463536463537" /psig="0.536463536463537" /xcortree=793 /SigmaFactorBS="tgtaccggtacagttcattgtttttctcATTGTAccgttctg accgcggCCATACAATAAAGGGAGCGaccggcgctgcaattcaggtaaaggagccctt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 387698..389032 /gene="ycxD" /locus_tag="BSU_03560" /old_locus_tag="BSU03560" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15223311, 26585522; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative PLP-dependent transcriptional regulator" /protein_id="NP_388238.1" /db_xref="EnsemblGenomes-Gn:BSU03560" /db_xref="EnsemblGenomes-Tr:CAB12150" /db_xref="GOA:Q08792" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10175" /db_xref="UniProtKB/Swiss-Prot:Q08792" /translation="MEKYMSLLTRIEEMMQSTSYQEGDRLPSIRQLSARYQVSKSTVI RALQELEKRHLIYSVPKSGYYIVKKSGKSKSGQPGPIDFATSAPDPDVFPYLDFQHCI NKAIDTYKNDLFIYGTPKGLPSLIRVLRKLLATQQVFADERHIFITSGVQQALSLLCA MPFPNGKEKIAIEQPGYHLMVEQLETLGIPAIGVKRTEEGLDIAKVERLFQTESIKFF YTMPRFHNPLGCSLSERDKQELVRLAEAYDVYLVEDDYLGDLEENKKADPLYAYDLSS HVIYLKSFSKMMFPGLRVGAAVLPEALTDTFYAYKKLNDIDCSMISQAALEIYLKSGM YGRHKEKIRDSYKERSLRLHQAIRTHRQLGSGRFTFSSGQAPCMHTHLVLPQDLPASR VIHRLEKQGVLLEAIDRHYLSDYPKENLLKINISNVKTEDIERGVKLLMSHL*" /label="ycxD CDS" gene 387698..389032 /gene="ycxD" /locus_tag="BSU_03560" /old_locus_tag="BSU03560" /label="ycxD gene" CDS complement(389027..389194) /gene="sfpAc" /locus_tag="BSU_03569" /old_locus_tag="BSU03569" /EC_number="2.7.8.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 10568751, 17376553, 2848009, 9384377, 14762003, 16707694, 19061923, 20971906, 25288929, 26268540; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="C-terminal part of 4'-phosphopantetheinyl transferase (Surfactin synthetase-activating enzyme)" /db_xref="PSEUDO:CAX52545.1" /translation="MRLHQDGQVSIELPDSHSPCYIKTYEVDPGYKMAVCAVHPDFPE DITMVSYEELL*" /label="sfpAc CDS" gene complement(389027..389194) /gene="sfpAc" /locus_tag="BSU_03569" /old_locus_tag="BSU03569" /pseudo /label="sfpAc gene" CDS complement(389205..389702) /gene="sfpAn" /locus_tag="BSU_03570" /old_locus_tag="BSU03570" /EC_number="2.7.8.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 10568751, 17376553, 2848009, 9384377, 14762003, 16707694, 19061923, 20971906, 25288929, 26268540; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="N-terminal part of 4'-phosphopantetheinyl transferase (surfactin synthetase-activating enzyme)" /db_xref="GOA:P39135" /db_xref="InterPro:IPR004568" /db_xref="InterPro:IPR008278" /db_xref="InterPro:IPR037143" /db_xref="PDB:1QR0" /db_xref="PDB:2GE0" /db_xref="PDB:2GE1" /db_xref="PDB:4MRT" /db_xref="PSEUDO:CAB12151.2" /db_xref="SubtiList:BG10176" /db_xref="UniProtKB/Swiss-Prot:P39135" /translation="MKIYGIYMDRPLSQEENERFMSFISPEKREKCRRFYHKEDAHRT LLGDVLVRSVISRQYQLDKSDIRFSTQEYGKPCIPDLPDAHFNISHSGRWVICAFDSQ PIGIDIEKTKPISLEIAKRFFSKTEYSDLLAKDKDEQTDYFYHLWSMKESFIKQGRQR LIASA*" /label="sfpAn CDS" gene complement(389205..389702) /gene="sfpAn" /locus_tag="BSU_03570" /old_locus_tag="BSU03570" /pseudo /label="sfpAn gene" misc_feature complement(389729..389748) /Source="Nicolas_upshift_promotors" /id="U273" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2243 /SigmaFactorBS="agccgccttggctttgtttttttattttctcctctatatgag tcttgtggaagTATGATAGGATGGTTTTGACaatcttttgcagacggaggatctagaa t" /listShort="sfp, sfp" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(389741) /Source="Nicolas_upshifts" /id="U273" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2243 /SigmaFactorBS="agccgccttggctttgtttttttattttctcctctatatgag tcttgtggaagTATGATAGGATGGTTTTGACaatcttttgcagacggaggatctagaa t" /listShort="sfp, sfp" /GFF_Attribute="listLong" /label="upshifts" CDS complement(389807..390454) /gene="yczE" /locus_tag="BSU_03580" /old_locus_tag="BSU03580" /function="15.11: Biosynthesis of natural products" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16850406, 17827323, 14762003, 16707694, 17827323, 25288929; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="integral inner membrane protein regulating antibiotic production" /protein_id="NP_388240.2" /db_xref="EnsemblGenomes-Gn:BSU03580" /db_xref="EnsemblGenomes-Tr:CAB12152" /db_xref="GOA:O34927" /db_xref="SubtiList:BG12779" /db_xref="UniProtKB/Swiss-Prot:O34927" /translation="MKQELVLRWTFYFAGLIILAFGVSLTIEGKALGISPWDAFHYSL FQHFGLTVGQWSIIIGALIVGFTSLFTRAWPKIGALLNMVLIGVFIDFFNFILPALST YTGSIIVFSLGVVLIGYGVGVYVSAGLGAGPRDSLMMLITEKTGWNVQWVRNGMELTI LFAAWGMGGPIGFGTILTAILTGLILRFSLPQSIQLLNYAVARRTAAVKASPPVH*" /label="yczE CDS" gene complement(389807..390454) /gene="yczE" /locus_tag="BSU_03580" /old_locus_tag="BSU03580" /label="yczE gene" promotor_-10 complement(390483..390502) /Source="Nicolas_upshift_promotors" /id="U274" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.866133866133866" /psig=1 /xcortree=2616 /SigmaFactorBS="tttttttgttgagcccctttcgccTATTCcgcccttctgtca gaTGTGCTACAATGACAATCGActgatttttacgaaagaagggacctcacgtgaagca a" /listShort="yczE, sfp, sfp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(390486) /Source="Nicolas_upshifts" /id="U274" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.866133866133866" /psig=1 /xcortree=2616 /SigmaFactorBS="tttttttgttgagcccctttcgccTATTCcgcccttctgtca gaTGTGCTACAATGACAATCGActgatttttacgaaagaagggacctcacgtgaagca a" /listShort="yczE, sfp, sfp" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(390518..390522) /Source="Nicolas_upshift_promotors" /id="U274" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.866133866133866" /psig=1 /xcortree=2616 /SigmaFactorBS="tttttttgttgagcccctttcgccTATTCcgcccttctgtca gaTGTGCTACAATGACAATCGActgatttttacgaaagaagggacctcacgtgaagca a" /listShort="yczE, sfp, sfp" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(390623..390774) /Source="Nicolas_S_feature" /locus_tag="new_409056_409207_c" /HighExp="G180, G135, dia15, H2O2, Diami, S8, Oxctl, G150, LPhT, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S127" CDS complement(390775..391518) /gene="tcyC" /locus_tag="BSU_03590" /old_locus_tag="BSU03590" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15262924, 16513748, 22212096" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15262924, 16513748, 22212096; Product type t: transporter" /codon_start=1 /transl_table=11 /product="cystine ABC transporter (ATP-binding protein)" /protein_id="NP_388241.2" /db_xref="EnsemblGenomes-Gn:BSU03590" /db_xref="EnsemblGenomes-Tr:CAB12153" /db_xref="GOA:P39456" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030679" /db_xref="SubtiList:BG11185" /db_xref="UniProtKB/Swiss-Prot:P39456" /translation="MLTVKGLNKSFGENEILKKIDMKIEKGKVIAILGPSGSGKTTLL RCLNALEIPNRGELAFDDFSIDFSKKVKQADILKLRRKSGMVFQAYHLFPHRTALENV MEGPVQVQKRNKEEVRKEAIQLLDKVGLKDKMDLYPFQLSGGQQQRVGIARALAIQPE LMLFDEPTSALDPELVGEVLKVIKDLANEGWTMVVVTHEIKFAQEVADEVIFIDGGVI VEQGPPEQIFSAPKEERTQRFLNRILNPL*" /label="tcyC CDS" gene complement(390775..391518) /gene="tcyC" /locus_tag="BSU_03590" /old_locus_tag="BSU03590" /label="tcyC gene" downshifts complement(390831) /Source="Nicolas_upshifts" /id="D157" /incds=0 /nref=72 /ntot=232 /MaxReadThrough="4.60958" /MaxDrop="4.44283" /score="1.62131565" /energy="-12.6" /TU="U275" /idTUdmin="U276" /TUdmin=4 /isTUend="TRUE" /label="downshifts" CDS complement(391532..392236) /gene="tcyB" /locus_tag="BSU_03600" /old_locus_tag="BSU03600" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15262924, 15849754, 16850406, 22212096" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15262924, 15849754, 16850406, 22212096; Product type t: transporter" /codon_start=1 /transl_table=11 /product="cystine ABC transporter (permease)" /protein_id="NP_388242.1" /db_xref="EnsemblGenomes-Gn:BSU03600" /db_xref="EnsemblGenomes-Tr:CAB12154" /db_xref="GOA:P42200" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11186" /db_xref="UniProtKB/Swiss-Prot:P42200" /translation="MFLNNLPALTLGTAIPWDLVQQSFWPILSGGIYYTIPLTILSFI FGMILALITALARMSKVRPLRWVFSVYVSAIRGTPLLVQLFIIFYLFPAFNVTLDPFP SAVIAFSLNVGAYASEIIRASILSVPKGQWEAGYTIGMTHQKTLFRVILPQAFRVSIP PLSNTFISLIKDTSLASQILVAELFRKAQEIGARNLDQILVIYIEAAFIYWIICFLLS LVQHVIERRLDRYVAK*" /label="tcyB CDS" gene complement(391532..392236) /gene="tcyB" /locus_tag="BSU_03600" /old_locus_tag="BSU03600" /label="tcyB gene" CDS complement(392223..393029) /gene="tcyA" /locus_tag="BSU_03610" /old_locus_tag="BSU03610" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15262924, 22212096" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15262924, 22212096; Product type t: transporter" /codon_start=1 /transl_table=11 /product="cystine ABC transporter (substrate-binding lipoprotein)" /protein_id="NP_388243.2" /db_xref="EnsemblGenomes-Gn:BSU03610" /db_xref="EnsemblGenomes-Tr:CAB12155" /db_xref="GOA:P42199" /db_xref="InterPro:IPR001638" /db_xref="InterPro:IPR018313" /db_xref="SubtiList:BG11187" /db_xref="UniProtKB/Swiss-Prot:P42199" /translation="MKKALLALFMVVSIAALAACGAGNDNQSKDNAKDGDLWASIKKK GVLTVGTEGTYEPFTYHDKDTDKLTGYDVEVITEVAKRLGLKVDFKETQWDSMFAGLN SKRFDVVANQVGKTDREDKYDFSDKYTTSRAVVVTKKDNNDIKSEADVKGKTSAQSLT SNYNKLATNAGAKVEGVEGMAQALQMIQQGRVDMTYNDKLAVLNYLKTSGNKNVKIAF ETGEPQSTYFTFRKGSGEVVDQVNKALKEMKEDGTLSKISKKWFGEDVSK*" /label="tcyA CDS" gene complement(392223..393029) /gene="tcyA" /locus_tag="BSU_03610" /old_locus_tag="BSU03610" /label="tcyA gene" promotor_-10 complement(393078..393097) /Source="Nicolas_upshift_promotors" /id="U275" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.913086913086913" /psig="0.987012987012987" /xcortree=1798 /SigmaFactorBS="ttttaaaagattttgtcttatgaaaaccaaatACTTGACTca tactaaaaaaaAGTTATCCTTTAGATTTGTAagctaattttttatttcaataaaatca a" /listShort="tcyA, tcyB, tcyC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(393090) /Source="Nicolas_upshifts" /id="U275" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.913086913086913" /psig="0.987012987012987" /xcortree=1798 /SigmaFactorBS="ttttaaaagattttgtcttatgaaaaccaaatACTTGACTca tactaaaaaaaAGTTATCCTTTAGATTTGTAagctaattttttatttcaataaaatca a" /listShort="tcyA, tcyB, tcyC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(393111..393118) /Source="Nicolas_upshift_promotors" /id="U275" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.913086913086913" /psig="0.987012987012987" /xcortree=1798 /SigmaFactorBS="ttttaaaagattttgtcttatgaaaaccaaatACTTGACTca tactaaaaaaaAGTTATCCTTTAGATTTGTAagctaattttttatttcaataaaatca a" /listShort="tcyA, tcyB, tcyC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(393145..394017) /gene="bsdA" /locus_tag="BSU_03620" /old_locus_tag="BSU03620" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17295427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17295427; Product type r: regulator" /codon_start=1 /transl_table=11 /product="HTH-type transcriptional regulator BsdA (LysR family)" /protein_id="NP_388244.1" /db_xref="EnsemblGenomes-Gn:BSU03620" /db_xref="EnsemblGenomes-Tr:CAB12156" /db_xref="GOA:P94403" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12022" /db_xref="UniProtKB/Swiss-Prot:P94403" /translation="MDIRQLRYFITIAQEQKITSAAKKLHMAQPPLSRQLKQLEDELG VVLFDRNKKKQMTLTYEGAVFLKRAKEILHRFEDAVIEVQELKEEVAGTLAVGSTIYC AALMLEKVTQIKERYPHLTFNIWENEPATLLELLESRQIDAAVTTTLIKSDTVQFKQL DDIPCVLVLSDEAGYPCGDTIKMVDIPSFPLILLRPVNGKGVYNQVMNEFHRLNLEPR IVCECHDSATLLSLVSSGFGASILPVTMIPVHMRNHVHTVHIENNPFIMTPAVMWRTD SYLPKPAQQFLDLF*" /label="bsdA CDS" gene complement(393145..394017) /gene="bsdA" /locus_tag="BSU_03620" /old_locus_tag="BSU03620" /label="bsdA gene" promotor_-10 complement(393755..393773) /Source="Nicolas_upshift_promotors" /id="U276" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=148 /SigmaFactorBS="ctaaaaagagcaaaagagattctgcataGGTTTGAagatgca gtcattgAGGTACAGGAGCTGAAGGAggaagtagccggtacacttgccgtgggatcaa c" /listShort="tcyA, tcyB, tcyC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(393762) /Source="Nicolas_upshifts" /id="U276" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=148 /SigmaFactorBS="ctaaaaagagcaaaagagattctgcataGGTTTGAagatgca gtcattgAGGTACAGGAGCTGAAGGAggaagtagccggtacacttgccgtgggatcaa c" /listShort="tcyA, tcyB, tcyC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(393788..393794) /Source="Nicolas_upshift_promotors" /id="U276" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=148 /SigmaFactorBS="ctaaaaagagcaaaagagattctgcataGGTTTGAagatgca gtcattgAGGTACAGGAGCTGAAGGAggaagtagccggtacacttgccgtgggatcaa c" /listShort="tcyA, tcyB, tcyC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 394071..394078 /Source="Nicolas_upshift_promotors" /id="U278" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.97902097902098" /xcortree=1580 /SigmaFactorBS="ccttttaggtattaattatagatttaatagaTATTTTTCata tggatatatcAGGAGTATGATTGAAATGAAagcagaattcaagcgtaaaggagggggc a" /listShort="ubiX, ubiD, bsdD, yclD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(394086..394105) /Source="Nicolas_upshift_promotors" /id="U277" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.978021978021978" /psig="0.985014985014985" /xcortree=1966 /SigmaFactorBS="cgagtttcactttgccccctcctttaCGCTTGAAttctgctt tcattTCAATCATACTCCTGATATAtccatatgaaaaatatctattaaatctataatt a" /listShort="yclA" /listLong="tcyA, tcyB, tcyC" /label="promotor_-10" promotor_-10 394092..394111 /Source="Nicolas_upshift_promotors" /id="U278" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.97902097902098" /xcortree=1580 /SigmaFactorBS="ccttttaggtattaattatagatttaatagaTATTTTTCata tggatatatcAGGAGTATGATTGAAATGAAagcagaattcaagcgtaaaggagggggc a" /listShort="ubiX, ubiD, bsdD, yclD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(394092) /Source="Nicolas_upshifts" /id="U277" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.978021978021978" /psig="0.985014985014985" /xcortree=1966 /SigmaFactorBS="cgagtttcactttgccccctcctttaCGCTTGAAttctgctt tcattTCAATCATACTCCTGATATAtccatatgaaaaatatctattaaatctataatt a" /listShort="yclA" /listLong="tcyA, tcyB, tcyC" /label="upshifts" upshifts 394100 /Source="Nicolas_upshifts" /id="U278" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.97902097902098" /xcortree=1580 /SigmaFactorBS="ccttttaggtattaattatagatttaatagaTATTTTTCata tggatatatcAGGAGTATGATTGAAATGAAagcagaattcaagcgtaaaggagggggc a" /listShort="ubiX, ubiD, bsdD, yclD" /GFF_Attribute="listLong" /label="upshifts" CDS 394107..394721 /gene="ubiX" /locus_tag="BSU_03630" /old_locus_tag="BSU03630" /EC_number="4.1.1.-" /EC_number="4.1.1.61" /function="3.2: Degradation" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 10919793, 15979273, 17295427, 18388975, 26083743, 26658822, 26337367; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phenolic acid decarboxylase-flavin prenyltransferase subunit" /protein_id="NP_388245.1" /db_xref="EnsemblGenomes-Gn:BSU03630" /db_xref="EnsemblGenomes-Tr:CAB12157" /db_xref="GOA:P94404" /db_xref="InterPro:IPR003382" /db_xref="InterPro:IPR004507" /db_xref="InterPro:IPR032901" /db_xref="InterPro:IPR036551" /db_xref="SubtiList:BG12023" /db_xref="UniProtKB/Swiss-Prot:P94404" /translation="MKAEFKRKGGGKVKLVVGMTGATGAIFGVRLLQWLKAAGVETHL VVSPWANVTIKHETGYTLQEVEQLATYTYSHKDQAAAISSGSFDTDGMIVAPCSMKSL ASIRTGMADNLLTRAADVMLKERKKLVLLTRETPLNQIHLENMLALTKMGTIILPPMP AFYNRPRSLEEMVDHIVFRTLDQFGIRLPEAKRWNGIEKQKGGA*" /label="ubiX CDS" gene 394107..394721 /gene="ubiX" /locus_tag="BSU_03630" /old_locus_tag="BSU03630" /label="ubiX gene" promotor_-35 complement(394119..394126) /Source="Nicolas_upshift_promotors" /id="U277" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.978021978021978" /psig="0.985014985014985" /xcortree=1966 /SigmaFactorBS="cgagtttcactttgccccctcctttaCGCTTGAAttctgctt tcattTCAATCATACTCCTGATATAtccatatgaaaaatatctattaaatctataatt a" /listShort="yclA" /listLong="tcyA, tcyB, tcyC" /label="promotor_-35" CDS 394724..396145 /gene="bsdC" /locus_tag="BSU_03640" /old_locus_tag="BSU03640" /EC_number="4.1.1.61" /EC_number="4.1.1.-" /function="3.2: Degradation" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 11029449, 15979273, 17295427, 18388975, 26658822, 26337367; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="promiscuous phenolic acid decarboxylase subunit;1,4-dihydroxy-2-naphtoate-heptaprenyl diphosphatedecarboxylase" /protein_id="NP_388246.1" /db_xref="EnsemblGenomes-Gn:BSU03640" /db_xref="EnsemblGenomes-Tr:CAB12158" /db_xref="GOA:P94405" /db_xref="InterPro:IPR002830" /db_xref="InterPro:IPR012349" /db_xref="InterPro:IPR032902" /db_xref="SubtiList:BG12024" /db_xref="UniProtKB/Swiss-Prot:P94405" /translation="MAYQDFREFLAALEKEGQLLTVNEEVKPEPDLGASARAASNLGD KSPALLFNNIYGYHNARIAMNVIGSWPNHAMMLGMPKDTPVKEQFFEFAKRYDQFPMP VKREETAPFHENEITEDINLFDILPLFRINQGDGGYYLDKACVISRDLEDPDNFGKQN VGIYRMQVKGKDRLGIQPVPQHDIAIHLRQAEERGINLPVTIALGCEPVITTAASTPL LYDQSEYEMAGAIQGEPYRIVKSKLSDLDVPWGAEVVLEGEIIAGEREYEGPFGEFTG HYSGGRSMPIIKIKRVYHRNNPIFEHLYLGMPWTECDYMIGINTCVPLYQQLKEAYPN EIVAVNAMYTHGLIAIVSTKTRYGGFAKAVGMRALTTPHGLGYCKMVIVVDEDVDPFN LPQVMWALSTKMHPKHDAVIIPDLSVLPLDPGSNPSGITHKMILDATTPVAPETRGHY SQPLDSPLTTKEWEQKLMDLMNK*" /label="bsdC CDS" gene 394724..396145 /gene="bsdC" /locus_tag="BSU_03640" /old_locus_tag="BSU03640" /label="bsdC gene" CDS 396162..396389 /gene="bsdD" /locus_tag="BSU_03651" /old_locus_tag="BSU03651" /EC_number="4.1.1.91" /EC_number="4.1.1.-" /EC_number="4.1.1.61" /function="3.2: Degradation" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 15979273, 17295427, 18388975, 26658822; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phenolic acid decarboxylase subunit" /protein_id="YP_003097675.1" /db_xref="EnsemblGenomes-Gn:BSU03651" /db_xref="EnsemblGenomes-Tr:CAX52546" /db_xref="GOA:C0H3U9" /db_xref="UniProtKB/Swiss-Prot:C0H3U9" /translation="MHTCPRCDSKKGEVMSKSPVEGAWEVYQCQTCFFTWRSCEPESI TNPEKYNPAFKIDPKETETAIEVPAVPERKA*" /label="bsdD CDS" gene 396162..396389 /gene="bsdD" /locus_tag="BSU_03651" /old_locus_tag="BSU03651" /label="bsdD gene" CDS 396386..396850 /gene="yclD" /locus_tag="BSU_03652" /old_locus_tag="BSU03652" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15979273, 18388975; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative FMN-binding enzyme subunit" /protein_id="NP_388247.2" /db_xref="EnsemblGenomes-Gn:BSU03652" /db_xref="EnsemblGenomes-Tr:CAB12159" /db_xref="GOA:C0SPB5" /db_xref="InterPro:IPR012349" /db_xref="SubtiList:BG12025" /db_xref="UniProtKB/Swiss-Prot:C0SPB5" /translation="MIRVNCMSDRLFELLDGSCLNEKQHEAFVLQTVSEDGWPHAAMI SAGEIIALSRTDIRIALWKNTMTSANILRTGKAQFTAWWKGAAYYVKLECAPLPPLKD AEYERDRFSCRIVSVKEDVAKYADLTSGVRIQLHSPEEVLSRWKKTLEDLKR*" /label="yclD CDS" gene 396386..396850 /gene="yclD" /locus_tag="BSU_03652" /old_locus_tag="BSU03652" /label="yclD gene" downshifts 396831 /Source="Nicolas_upshifts" /id="D158" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="3.32586" /MaxDrop="3.88166" /score="45.8937489" /energy="-15.1" /TU="NA" /idTUdmin="U278" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature 396857..396858 /Source="Nicolas_upshift_promotors" /id="U279" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.357642357642358" /psig="0.557442557442557" /xcortree=3132 /SigmaFactorBS="ctgaagaggtgctgagcagatggaaaaagaccctggaagatt taaaacggtaatatcgaTAgcctgacgccatgcgtcaggctttttttatataatgaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 396858 /Source="Nicolas_upshifts" /id="U279" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.357642357642358" /psig="0.557442557442557" /xcortree=3132 /SigmaFactorBS="ctgaagaggtgctgagcagatggaaaaagaccctggaagatt taaaacggtaatatcgaTAgcctgacgccatgcgtcaggctttttttatataatgaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 396917..397762 /gene="yclE" /locus_tag="BSU_03660" /old_locus_tag="BSU03660" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_388248.2" /db_xref="EnsemblGenomes-Gn:BSU03660" /db_xref="EnsemblGenomes-Tr:CAB12160" /db_xref="GOA:P94407" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12026" /db_xref="UniProtKB/Swiss-Prot:P94407" /translation="MERAGICHSDGFDLAYRIEGEGAPILVIGSAVYYPRLFSSDIKQ KYQWVFVDHRGFAKPKRELRAEDSRLDAVLADIERMRTFLQLEDVTILGHSGHAFMAL EYARTYPKQVRKVALFNTAPDNSEERQRKSESFFMETASLERKKRFEKDIENLPQDID KDPERRFVHMCIRAEAKSFYQERPHAAALWDGVFTNMPIIDELWGNTFARIDLLQRLA DVRMPVYIGLGRYDYLVAPVSLWDAVDGLYPHVDKVIFEKSGHQPMLEEPEAFDQSFR KWLDQ*" /label="yclE CDS" gene 396917..397762 /gene="yclE" /locus_tag="BSU_03660" /old_locus_tag="BSU03660" /label="yclE gene" CDS complement(397802..399280) /gene="dtpT" /locus_tag="BSU_03670" /old_locus_tag="BSU03670" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8458848, 11717292, 15849754, 16204487, 16850406, 17496096, 23144141, 25966844; Product type t: transporter" /codon_start=1 /transl_table=11 /product="di-tripeptide-proton ABC symporter" /protein_id="NP_388249.2" /db_xref="EnsemblGenomes-Gn:BSU03670" /db_xref="EnsemblGenomes-Tr:CAB12175" /db_xref="GOA:P94408" /db_xref="InterPro:IPR000109" /db_xref="InterPro:IPR005279" /db_xref="InterPro:IPR018456" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12027" /db_xref="UniProtKB/Swiss-Prot:P94408" /translation="MASIDNESIIKSVPQKGFFGHPRGLFTLFFTEFWERFSYYGMRA ILLYYLYTETVNGGLGFDKGTAVAIMSIYGSLVYMSTIIGGWLADRVFGTANTVFYGG IFIMFGHIALAYPGSSIAFYISMVLIIVGTGLLKPNVSSVVGDLYTKEDPRRDSGFSI FYMGINLGGLLAPLIVGTLGQKYNYHLGFGAAAVGMLLGLIVFALTRKKNLGLAGSNV PNPLSKKSAIGTGIGVIIVAIAVIISVQTGVLTIKRFIDLVSILGILIPVIYFIIMFT SKKADKTEKSRLAAYVPLFIGAVMFWAIQEQGATILAVYADERIRLSLGGFELQSSWF QSLNPLFVVIFAPIFAWLWMKLGKRQPSTPVKFSIGIILAGLSFIIMVFPAMQGKEAL VSPLWLVLSFLLVVLGELCLSPVGLSVTTKLAPAAFSAQTMSMWFLTNAAAQAINAQV AGLFDKIPETMYFGTIGLISIVLGGILLLLSPVIKRAMKGVL*" /label="dtpT CDS" gene complement(397802..399280) /gene="dtpT" /locus_tag="BSU_03670" /old_locus_tag="BSU03670" /label="dtpT gene" downshifts complement(397810) /Source="Nicolas_upshifts" /id="D159" /incds=0 /nref=17 /ntot=90 /MaxReadThrough="1.40624" /MaxDrop="3.91827" /score="43.5753464" /energy="-21" /TU="NA" /idTUdmin="U281" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 399307..399309 /Source="Nicolas_upshift_promotors" /id="U280" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.257742257742258" /psig="0.581418581418581" /xcortree=1444 /SigmaFactorBS="ctttcgttatcaatcgaagccatgtcagccaaaccctttcta aaaaaagTGTattataaaaatcatatTCTTATATAATACTTGTGTcaatataatttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(399308..399327) /Source="Nicolas_upshift_promotors" /id="U281" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.97002997002997" /xcortree=1442 /SigmaFactorBS="tttttccaatatggaactatttgaaatgagtataaattaTAT TGACAcaagtattatataaGAATATGATTTTTATAATACactttttttagaaagggtt t" /listShort="dtpT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 399318 /Source="Nicolas_upshifts" /id="U280" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.257742257742258" /psig="0.581418581418581" /xcortree=1444 /SigmaFactorBS="ctttcgttatcaatcgaagccatgtcagccaaaccctttcta aaaaaagTGTattataaaaatcatatTCTTATATAATACTTGTGTcaatataatttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 399326..399344 /Source="Nicolas_upshift_promotors" /id="U280" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.257742257742258" /psig="0.581418581418581" /xcortree=1444 /SigmaFactorBS="ctttcgttatcaatcgaagccatgtcagccaaaccctttcta aaaaaagTGTattataaaaatcatatTCTTATATAATACTTGTGTcaatataatttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(399328) /Source="Nicolas_upshifts" /id="U281" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.97002997002997" /xcortree=1442 /SigmaFactorBS="tttttccaatatggaactatttgaaatgagtataaattaTAT TGACAcaagtattatataaGAATATGATTTTTATAATACactttttttagaaagggtt t" /listShort="dtpT" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(399330..399834) /Source="Nicolas_S_feature" /locus_tag="new_417763_418267_c" /HighExp="S3, S4, LoTm, S5, S6, T5.0H, T4.0H, M9-stat, S8, T3.30H" /AntisenseName="yclG" /AntisenseCor="0.33937447534762299" /AntisenseRegPval="-7.9" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S128" promotor_-35 complement(399342..399349) /Source="Nicolas_upshift_promotors" /id="U281" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.97002997002997" /xcortree=1442 /SigmaFactorBS="tttttccaatatggaactatttgaaatgagtataaattaTAT TGACAcaagtattatataaGAATATGATTTTTATAATACactttttttagaaagggtt t" /listShort="dtpT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 399498..399507 /Source="Nicolas_upshift_promotors" /id="U282" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1425 /SigmaFactorBS="attcctttatatttttttaataaaattttagagaaatGTACA AGCAGatcgggcctttgTGAGTAACATGATAGTAATCatagagaaggaggctcgcaat t" /listShort="yclG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 399520..399539 /Source="Nicolas_upshift_promotors" /id="U282" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1425 /SigmaFactorBS="attcctttatatttttttaataaaattttagagaaatGTACA AGCAGatcgggcctttgTGAGTAACATGATAGTAATCatagagaaggaggctcgcaat t" /listShort="yclG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 399521 /Source="Nicolas_upshifts" /id="U282" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1425 /SigmaFactorBS="attcctttatatttttttaataaaattttagagaaatGTACA AGCAGatcgggcctttgTGAGTAACATGATAGTAATCatagagaaggaggctcgcaat t" /listShort="yclG" /GFF_Attribute="listLong" /label="upshifts" CDS 399560..401314 /gene="yclG" /locus_tag="BSU_03680" /old_locus_tag="BSU03680" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative uronase" /protein_id="NP_388250.1" /db_xref="EnsemblGenomes-Gn:BSU03680" /db_xref="EnsemblGenomes-Tr:CAB12176" /db_xref="InterPro:IPR006626" /db_xref="InterPro:IPR006633" /db_xref="InterPro:IPR011050" /db_xref="InterPro:IPR012334" /db_xref="InterPro:IPR024535" /db_xref="SubtiList:BG12028" /db_xref="UniProtKB/Swiss-Prot:P94409" /translation="MAEFILNAADFGVPRDGKTDSTERINQCLSTAVSKGYHTVWFPK GTYLIDATLGGDLNQRFRNAGIIVPGNLEIMMDPECIMKVIPNSSWGYSAFYVGKQEN ITISGGQIIGERDEHTYASAGIRSTHEWGFGICIEGCSNVVIDDVKISDFTGDGIIVS PRGLKTNQDYRTSEQIIIRRCEVRRSRRNNISITGCDMVTVEECLIEDAGTGNGTAPK FGIDIEGYGEGDVDYEEPINVSIRNNHFVGNVSSSVTNFNGYGILIEGNHSDNTISYG YGTQTVIKGNILRRPEDAAAAPRVGITGLGVSQGKETSDAVIAGNLITGFSTGIDVRG KSVLVTNNKISNFENTGILVYQSSDVKVDGNQIQNGLSETRRSIGLRAVLSDDIAFLN NCLIQVVDGVNVSGGNMIIKDNLLRKFSRGIWIAQGNAVIEGNTLNPDAFEAVPESYS VSVTNNAGAIIKNNTFKEFKNYPIYCSTSAKTSIIGNHLERSPLLVTIYISAGVHEIF DNTISVNRTAGNPIVIYLNGSAGSIISGNTINNLSAGTATAIQTNTSTNSKIIGNRIF KGTINKHSSDTIDGNMIV*" /label="yclG CDS" gene 399560..401314 /gene="yclG" /locus_tag="BSU_03680" /old_locus_tag="BSU03680" /label="yclG gene" promotor_-10 complement(399831..399849) /Source="Nicolas_upshift_promotors" /id="U283" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1003 /SigmaFactorBS="atcccgttcgccgataatttgtcctccggaaataGTTATAtt ctcttgcttgcctACATAAAATGCGGAATAACcccacgaactattcggtatcactttc a" /listShort="S128, dtpT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(399844) /Source="Nicolas_upshifts" /id="U283" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1003 /SigmaFactorBS="atcccgttcgccgataatttgtcctccggaaataGTTATAtt ctcttgcttgcctACATAAAATGCGGAATAACcccacgaactattcggtatcactttc a" /listShort="S128, dtpT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(399865..399870) /Source="Nicolas_upshift_promotors" /id="U283" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1003 /SigmaFactorBS="atcccgttcgccgataatttgtcctccggaaataGTTATAtt ctcttgcttgcctACATAAAATGCGGAATAACcccacgaactattcggtatcactttc a" /listShort="S128, dtpT" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 401305 /Source="Nicolas_upshifts" /id="D160" /incds=0 /nref=6 /ntot=21 /MaxReadThrough="0.325519999999999" /MaxDrop="4.9689" /score="4.29139266" /energy="-5.4" /TU="NA" /idTUdmin="U282" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS complement(401330..401551) /gene="yczF" /locus_tag="BSU_03690" /old_locus_tag="BSU03690" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388251.1" /db_xref="EnsemblGenomes-Gn:BSU03690" /db_xref="EnsemblGenomes-Tr:CAB12177" /db_xref="GOA:O31479" /db_xref="SubtiList:BG12780" /db_xref="UniProtKB/Swiss-Prot:O31479" /translation="MKILGVTGFILICLLAISVLMDMLQGFSLTKAVYNNMSSFKMTT FAEWVVLLFFVLVLVREMYVIYKSKKKNP*" /label="yczF CDS" gene complement(401330..401551) /gene="yczF" /locus_tag="BSU_03690" /old_locus_tag="BSU03690" /label="yczF gene" promotor_-10 complement(401570..401581) /Source="Nicolas_upshift_promotors" /id="U284" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=857 /SigmaFactorBS="aaattgagattatgcattagggttagatgcGGTATAActtct ccgccaaagATAGACACTAAAagcggaggatgatgaagcatgaagatattgggcgtga c" /listShort="yczF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(401572) /Source="Nicolas_upshifts" /id="U284" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=857 /SigmaFactorBS="aaattgagattatgcattagggttagatgcGGTATAActtct ccgccaaagATAGACACTAAAagcggaggatgatgaagcatgaagatattgggcgtga c" /listShort="yczF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(401596..401602) /Source="Nicolas_upshift_promotors" /id="U284" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=857 /SigmaFactorBS="aaattgagattatgcattagggttagatgcGGTATAActtct ccgccaaagATAGACACTAAAagcggaggatgatgaagcatgaagatattgggcgtga c" /listShort="yczF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 401617..401623 /Source="Nicolas_upshift_promotors" /id="U285" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=903 /SigmaFactorBS="gagaagttataccgcatctaaccctaaTGCATAAtctcaatt ttaaaAGGAAGAATATGagaaaacgacaaggaaaggtatttgtgtatgcctttatttt c" /listShort="gerKA, gerKC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 401637..401648 /Source="Nicolas_upshift_promotors" /id="U285" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=903 /SigmaFactorBS="gagaagttataccgcatctaaccctaaTGCATAAtctcaatt ttaaaAGGAAGAATATGagaaaacgacaaggaaaggtatttgtgtatgcctttatttt c" /listShort="gerKA, gerKC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 401650 /Source="Nicolas_upshifts" /id="U285" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=903 /SigmaFactorBS="gagaagttataccgcatctaaccctaaTGCATAAtctcaatt ttaaaAGGAAGAATATGagaaaacgacaaggaaaggtatttgtgtatgcctttatttt c" /listShort="gerKA, gerKC" /GFF_Attribute="listLong" /label="upshifts" CDS 401677..403311 /gene="gerKA" /locus_tag="BSU_03700" /old_locus_tag="BSU03700" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10762253, 16707705, 16740944" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10762253, 16707705, 16740944; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination receptor subunit" /protein_id="NP_388252.1" /db_xref="EnsemblGenomes-Gn:BSU03700" /db_xref="EnsemblGenomes-Tr:CAB12178" /db_xref="GOA:P49939" /db_xref="InterPro:IPR004995" /db_xref="SubtiList:BG11392" /db_xref="UniProtKB/Swiss-Prot:P49939" /translation="MPLFSKRKNNTDSKDKQNTDERNQEQQQEKERPVLISPSLAKNI AETKKEVGSSSDVIIREIKIGEQDHVHLAVIYISGLVDNNTIHESLIDPLVQDESIQN THAIQQILEKTLPLGGVKAEKSWDKLFSELMLGNALIFADGHDEALICSTQGGEQRSI QEPSTQVSFRGPRQGFTESLQTNISMIRRYIKNPNLWVEKMKKGSVTNTDIALMYIQG ICDEKVLKEVKQRLEKIDIDSILESGYIEQLIEDETFTTFPTMYHTERPDVVAGNLLE GRFAIIVDGTPFVLIAPALFVQFFQSVEDYYSRFDIATSIRILRVLVFFISLVAPAVY VAATTFHQEMIPTQLLVVIAAQREIVPFPAVVEALTMEVAFEILREAGVRLPRVVGSA VSIVGALVIGQAAVQAGIVSPAMVIIVALTAIASFATPAFAMAISARLIRFIFIIASA VMGFYGLILGIIMMFVHLCSLRSFGVPYMSPLAPFSSQGVKDALFRVPWWADEKRPES VSKEDKVRQGKDQRPEPAASRGMVNKDLEEGDQNGT*" /label="gerKA CDS" gene 401677..403311 /gene="gerKA" /locus_tag="BSU_03700" /old_locus_tag="BSU03700" /label="gerKA gene" CDS 403301..404524 /gene="gerKC" /locus_tag="BSU_03710" /old_locus_tag="BSU03710" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10762253, 16707705, 16740944, 19363077" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10762253, 16707705, 16740944, 19363077; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination receptor subunit" /protein_id="NP_388253.1" /db_xref="EnsemblGenomes-Gn:BSU03710" /db_xref="EnsemblGenomes-Tr:CAB12179" /db_xref="GOA:P49941" /db_xref="InterPro:IPR008844" /db_xref="SubtiList:BG11394" /db_xref="UniProtKB/Swiss-Prot:P49941" /translation="MVRKCLLAVLMLLSVIVLPGCWDKRELTDLAIISAIGIDRTNDS NYVLHLQIINPGNVAGGLQGGGAGDRPPVSVYSIEGNNITEALRKASMKVSRRLYFAH TNLVVINEKLAKEEGLDFVLDNLDRDTEFRTTATFVVAHKTKAENIVKILTPIDKIPS NKVNKTLDFTEAQYGRVVKINIQDVLKTLAANTMAPVIPGYMMIGDDKKGVSMENTQA TDPKAILQADGLAVFDKAGYLKYWLEDDESVGAVWLMNKIQHTFINADWGKTKDAVSL QVTHQDTKLVPKMRNGRPYIHVKVSVEGIIDAVKYPFQLSDPKVLAAIEKALNKELEK EISHTVKKIKKNKIDFIGFGDTIYRKYPEQWEKMKDTWDKEYLPELPIDVKAETYIRR TGLRNNPIKHQFKDD*" /label="gerKC CDS" gene 403301..404524 /gene="gerKC" /locus_tag="BSU_03710" /old_locus_tag="BSU03710" /label="gerKC gene" CDS 404549..405670 /gene="gerKB" /locus_tag="BSU_03720" /old_locus_tag="BSU03720" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10762253, 15849754, 16707705, 16740944, 16850406, 19363077" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10762253, 15849754, 16707705, 16740944, 16850406, 19363077; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="spore germination receptor subunit" /protein_id="NP_388254.1" /db_xref="EnsemblGenomes-Gn:BSU03720" /db_xref="EnsemblGenomes-Tr:CAB12180" /db_xref="GOA:P49940" /db_xref="InterPro:IPR004761" /db_xref="SubtiList:BG11393" /db_xref="UniProtKB/Swiss-Prot:P49940" /translation="MEKARISIRQLFVMIIIFELGSSLLITPGSMAGRDAWIAVLLGC AIGLFLFYLYQGIYQCYPNSSPKEYMDDMLGTKLSWLFSFLYILYFAYIAARVLRDFG EMLLTFAYHDTPIIIVNALLMVVSIYAVRKGIEVLARAAELLFGAMYLLGAIGLVLII VSGTIDPHNLKPVLANGISPVLHSVFTQTMYVPFGEVVLFVMIFPNLNDRKDVKKMGM IAMAISGLIVALTVAINISVLDVDLTLRSQFPLLSTIQTIKVEEFLDRLDVFFMLALI IGGFFKVSLYLYATVVGTSTLFKEKNPSQLAYPMGLGILILSITIATNFSEHLNEGLN VVPLYIHLPFQLLFPLFLFIVAVWKKKRREKSKGEEAKK*" /label="gerKB CDS" gene 404549..405670 /gene="gerKB" /locus_tag="BSU_03720" /old_locus_tag="BSU03720" /label="gerKB gene" downshifts 405654 /Source="Nicolas_upshifts" /id="D161" /incds=0 /nref=6 /ntot=58 /MaxReadThrough="2.55658" /MaxDrop="3.73002" /score="3.39927899" /energy="-10.5" /TU="NA" /idTUdmin="U285" /TUdmin=2200 /isTUend="FALSE" /label="downshifts" CDS complement(405775..406455) /gene="yclH" /locus_tag="BSU_03730" /old_locus_tag="BSU03730" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATPase component)" /protein_id="NP_388255.1" /db_xref="EnsemblGenomes-Gn:BSU03730" /db_xref="EnsemblGenomes-Tr:CAB12181" /db_xref="GOA:P94411" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12029" /db_xref="UniProtKB/Swiss-Prot:P94411" /translation="MSLLQFQQVGYWYKNKSQPLFQDINISFQKGKFYTIVGTSGTGK TTFLSLAGGLDAPKEGNILYDGKAVSKIGLTNFRNQYVSIVFQAYNLLPYMTALQNVT TAMEITGSKEKNKESYALDMLQKVGINEKQARQKVLTLSGGQQQRVSITRAFCCDTDL IVADEPTGNLDEDTSKEIVRLFQDLAHKEDKCVIMVTHDEQIAKVSDINIRLSRGSFT VKENVAVV*" /label="yclH CDS" gene complement(405775..406455) /gene="yclH" /locus_tag="BSU_03730" /old_locus_tag="BSU03730" /label="yclH gene" CDS complement(406471..407931) /gene="yclI" /locus_tag="BSU_03740" /old_locus_tag="BSU03740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_388256.2" /db_xref="EnsemblGenomes-Gn:BSU03740" /db_xref="EnsemblGenomes-Tr:CAB12182" /db_xref="GOA:P94412" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR025857" /db_xref="SubtiList:BG12030" /db_xref="UniProtKB/Swiss-Prot:P94412" /translation="MNFIKRAFWNMKAKKGKTLLQLFVFTVICVFVLSGLAIQSAAQK SSELARQELGGSVTLQVDRQKQMEKQQDSGEKRSFESTPIKVSDANKLAALDHVKSYN YTTSASANAGNFDAIESSSSSDSSSSSSSSNAKNSQGGGQGGPQMVQADLSIEGVIST ALVDDFSDGDSKITDGRAITKSDVGKKVTVINETLAEENDLSVGDSITIESATDEDTT VKLKIVGIYKTTSSGDDQAQNFSFLNPYNKLYTPYTATAALKGDDYKNTIDSAVYYMD DAKNMDTFVKAAKKTSIDFDTYTLNTNDQLYQQMVGPIENVASFSKNVVYLVSVAGAV ILGLIVMMSIRERKYEMGVLMAIGEKRWKLIGQFLTEILIVAVIAIGLASVTGNLVAN QLGNQLLSQQISSSTDSTQTASGQMPGGGGGMGGKMFGHSSSNVDVIDSLNVAVSMND MLILGGIGILIAIIATLLPSISVLRLHPKTILTKQE*" /label="yclI CDS" gene complement(406471..407931) /gene="yclI" /locus_tag="BSU_03740" /old_locus_tag="BSU03740" /label="yclI gene" misc_feature 408101..408120 /Source="Nicolas_upshift_promotors" /id="U286" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.647352647352647" /psig="0.962037962037962" /xcortree=1584 /SigmaFactorBS="tctagttgatgaaataaaaactaacaattgtgaaacgcaaaa ccttctgtttaaaatGGTGCTATTATATAAAAAAGcatcaaaacaaccggaggatata a" /listShort="yclJ, yclK, S129, rapC, phrC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 408104 /Source="Nicolas_upshifts" /id="U286" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.647352647352647" /psig="0.962037962037962" /xcortree=1584 /SigmaFactorBS="tctagttgatgaaataaaaactaacaattgtgaaacgcaaaa ccttctgtttaaaatGGTGCTATTATATAAAAAAGcatcaaaacaaccggaggatata a" /listShort="yclJ, yclK, S129, rapC, phrC" /GFF_Attribute="listLong" /label="upshifts" CDS 408144..408827 /gene="yclJ" /locus_tag="BSU_03750" /old_locus_tag="BSU03750" /function="16.10: Respire" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 15375128, 20512483" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15375128, 20512483; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YclK] (possibly involved in arabinogalactan metabolism)" /protein_id="NP_388257.1" /db_xref="EnsemblGenomes-Gn:BSU03750" /db_xref="EnsemblGenomes-Tr:CAB12183" /db_xref="GOA:P94413" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12031" /db_xref="UniProtKB/Swiss-Prot:P94413" /translation="MKILMIEDNVSVCTMTEMFFFKEGFEAEFVHDGLEGYQRFTEEN WDLIILDIMLPSMDGVTICRKIRETSTVPIIMLTAKDTESDQVIGFEMGADDYVTKPF SPLTLVARIKAVIRRYKATGKAVIDEDMIETECFTINKKTREVLLNGEPVENLTPKEF DLLYYLVQNPRQVFSREQLLEQVWGYQFYGDERTVDVHIKRLRKKLASEDKPFLYTVW GVGYKFDED*" /label="yclJ CDS" gene 408144..408827 /gene="yclJ" /locus_tag="BSU_03750" /old_locus_tag="BSU03750" /label="yclJ gene" CDS 408814..410235 /gene="yclK" /locus_tag="BSU_03760" /old_locus_tag="BSU03760" /function="16.3: Control" /function="16.10: Respire" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 15375128, 20512483" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15375128, 20512483; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YclJ]" /protein_id="NP_388258.1" /db_xref="EnsemblGenomes-Gn:BSU03760" /db_xref="EnsemblGenomes-Tr:CAB12184" /db_xref="GOA:P94414" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12032" /db_xref="UniProtKB/Swiss-Prot:P94414" /translation="MMKIKYLYQLLLSHISILILAFVIIISLFSHFVKEFAYQNKVEE LTSYAVQIANEFQSGQVDMRRLYPYQDILSTRKTQFIIFNEEQQPYFLPEGFHHPPRE QLKKSEWNKLKKGQTVTIRADGRFDDEVSLVAQPIFVQNEFKGAVLLISPISGVEQMV NQVNLYMFYAVISTLVITILVSWLLSKFHVKRIQKLREATDKVASGDYDIHLENSYGD EIGVLASDFNIMAKKLKQSRDEIERLEKRRRQFIADVSHELKTPLTTINGLVEGLNSH TIPEDKKDKCFSLISEETKRMLRLVKENLDYEKIRSQQITLNKLDVPLIEVFEIVKEH LQQQAEEKQNKLMIQVEDHVIVHADYDRFIQILVNITKNSIQFTQNGDIWLRGMEGYK ETIIEIEDTGIGIPKEDIEHIWERFYKADISRTNTAYGEYGLGLSIVRQLVEMHQGTV EIKSEEGKGTKFIIRLPLTAKQQ*" /label="yclK CDS" gene 408814..410235 /gene="yclK" /locus_tag="BSU_03760" /old_locus_tag="BSU03760" /label="yclK gene" downshifts 410211 /Source="Nicolas_upshifts" /id="D162" /incds=0 /nref=20 /ntot=169 /MaxReadThrough="3.43905" /MaxDrop="4.91565" /score="13.4599201" /energy="-15" /TU="U286" /idTUdmin="U286" /TUdmin="-1427" /isTUend="FALSE" /label="downshifts" S_feature 410256..410360 /Source="Nicolas_S_feature" /locus_tag="new_428689_428793" /HighExp="Lbstat, nit, ferm, BI, M0t45, M40t45, M0t90, S0, S2, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.962" /TUlongSig="NA" /TUlongPSig="NA" /label="S129" misc_feature 410350..410369 /Source="Nicolas_upshift_promotors" /id="U287" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.96903096903097" /psig="0.986013986013986" /xcortree=678 /SigmaFactorBS="tcccgaaaacaaagattgcgtgtttttcgggttgggacggcc tataaaCATGATAAAATATGACATAAacagtttttgatgggagagggtgaaggaatga a" /listShort="rapC, phrC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 410362 /Source="Nicolas_upshifts" /id="U287" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.96903096903097" /psig="0.986013986013986" /xcortree=678 /SigmaFactorBS="tcccgaaaacaaagattgcgtgtttttcgggttgggacggcc tataaaCATGATAAAATATGACATAAacagtttttgatgggagagggtgaaggaatga a" /listShort="rapC, phrC" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(410394) /Source="Nicolas_upshifts" /id="D163" /incds=0 /nref=2 /ntot=81 /MaxReadThrough="1.74985" /MaxDrop="4.10695" /score="1.47729412" /energy="-10.3" /TU="NA" /idTUdmin="U290" /TUdmin=1320 /isTUend="FALSE" /label="downshifts" CDS 410398..411546 /gene="rapC" /locus_tag="BSU_03770" /old_locus_tag="BSU03770" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10464187, 12456319, 12897006, 12950917, 15968044, 19202088" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10464187, 12456319, 12897006, 12950917, 15968044, 19202088; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="response regulator aspartate phosphatase" /protein_id="NP_388259.1" /db_xref="EnsemblGenomes-Gn:BSU03770" /db_xref="EnsemblGenomes-Tr:CAB12185" /db_xref="GOA:P94415" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="SubtiList:BG11966" /db_xref="UniProtKB/Swiss-Prot:P94415" /translation="MKSGVIPSSAVGQKINEWYRYIRTFSVPDAEVLKAEIQQELKHM QHDSNLLLYYSLMEFRHQLMLDYLEPLEKLNIEDQPSLSELSRNIDSNQADLKGLLDY YVNFFRGMYEFDKREFISAITYYKQAEKKLSFVADHIERAEFYFKIAEAYYYMKQTYF SLINIKNAYEIYVEQETYNVRIIQCHFVFGVNLMDERNFEQAARHFKLALNMAQAEQK AQLVGRAYYNLGLCYYNQDLLDPAIDYFEKAVSTFESSRIVNSLPQAYFLITLIYYKQ GKHDKASEYHKRGYEYAKETDDADYAVKFEFLQSLYLDQPNEEGIERCFQYLKNKNMY ADIEDLALEVAKYYYEQKWFKLSASYFLQVEEARKQIQRSEGLYEIEI*" /label="rapC CDS" gene 410398..411546 /gene="rapC" /locus_tag="BSU_03770" /old_locus_tag="BSU03770" /label="rapC gene" promotor_-35 411246..411251 /Source="Nicolas_upshift_promotors" /id="U288" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.776223776223776" /psig="0.776223776223776" /xcortree=1063 /SigmaFactorBS="caccctgatttattataaacagggaaaacatgataaagcttc GGAATAtcacaagcggggctatGAATATGCTAAAGAAACAGacgatgcagactatgcc g" /listShort="phrC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 411264 /Source="Nicolas_upshifts" /id="U288" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.776223776223776" /psig="0.776223776223776" /xcortree=1063 /SigmaFactorBS="caccctgatttattataaacagggaaaacatgataaagcttc GGAATAtcacaagcggggctatGAATATGCTAAAGAAACAGacgatgcagactatgcc g" /listShort="phrC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 411268..411286 /Source="Nicolas_upshift_promotors" /id="U288" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.776223776223776" /psig="0.776223776223776" /xcortree=1063 /SigmaFactorBS="caccctgatttattataaacagggaaaacatgataaagcttc GGAATAtcacaagcggggctatGAATATGCTAAAGAAACAGacgatgcagactatgcc g" /listShort="phrC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 411408..411416 /Source="Nicolas_upshift_promotors" /id="U289" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.753246753246753" /psig="0.753246753246753" /xcortree=788 /SigmaFactorBS="taaaaaataaaaatatgtacgctgatatAGAGGATTTagccc tagaagTAGCAAAATATTACTATGAacagaaatggtttaaactgtctgcttcctactt t" /listShort="phrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 411428..411446 /Source="Nicolas_upshift_promotors" /id="U289" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.753246753246753" /psig="0.753246753246753" /xcortree=788 /SigmaFactorBS="taaaaaataaaaatatgtacgctgatatAGAGGATTTagccc tagaagTAGCAAAATATTACTATGAacagaaatggtttaaactgtctgcttcctactt t" /listShort="phrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 411440 /Source="Nicolas_upshifts" /id="U289" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.753246753246753" /psig="0.753246753246753" /xcortree=788 /SigmaFactorBS="taaaaaataaaaatatgtacgctgatatAGAGGATTTagccc tagaagTAGCAAAATATTACTATGAacagaaatggtttaaactgtctgcttcctactt t" /listShort="phrC" /GFF_Attribute="listLong" /label="upshifts" CDS 411530..411652 /gene="phrC" /locus_tag="BSU_03780" /old_locus_tag="BSU03780" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10464187, 12456319, 12897006, 12950917, 16816200, 19202088" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10464187, 12456319, 12897006, 12950917, 16816200, 19202088; Product type r : regulator" /codon_start=1 /transl_table=11 /product="secreted regulator of the activity of phosphatase RapC and competence and sporulation stimulating factor (CSF)" /protein_id="NP_388260.1" /db_xref="EnsemblGenomes-Gn:BSU03780" /db_xref="EnsemblGenomes-Tr:CAB12186" /db_xref="GOA:P94416" /db_xref="InterPro:IPR020243" /db_xref="InterPro:IPR025899" /db_xref="SubtiList:BG11959" /db_xref="UniProtKB/Swiss-Prot:P94416" /translation="MKLKSKLFVICLAAAAIFTAAGVSANAEALDFHVTERGMT*" /label="phrC CDS" gene 411530..411652 /gene="phrC" /locus_tag="BSU_03780" /old_locus_tag="BSU03780" /label="phrC gene" downshifts 411639 /Source="Nicolas_upshifts" /id="D164" /incds=0 /nref=260 /ntot=275 /MaxReadThrough="3.24518" /MaxDrop="7.70367" /score="26.3182765" /energy="-14" /TU="NA" /idTUdmin="U286" /TUdmin=1 /isTUend="TRUE" /label="downshifts" downshifts complement(411707) /Source="Nicolas_upshifts" /id="D165" /incds=0 /nref=3 /ntot=64 /MaxReadThrough="0.60499" /MaxDrop="7.4475" /score="-1.25354129" /energy="-15.8" /TU="NA" /idTUdmin="U290" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS complement(411752..411841) /gene="yczM" /locus_tag="BSU_03788" /old_locus_tag="BSU03788" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20156992, 21670523; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative type I toxin" /protein_id="YP_003097676.1" /db_xref="EnsemblGenomes-Gn:BSU03788" /db_xref="EnsemblGenomes-Tr:CAX52547" /db_xref="GOA:C0H3V0" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/Swiss-Prot:C0H3V0" /translation="MSGYGTSFALIVVLFILLIIVGTAFVGGY*" /label="yczM CDS" gene complement(411752..411841) /gene="yczM" /locus_tag="BSU_03788" /old_locus_tag="BSU03788" /label="yczM gene" downshifts complement(411912) /Source="Nicolas_upshifts" /id="D166" /incds=0 /nref=25 /ntot=113 /MaxReadThrough="7.05273" /MaxDrop="3.3619" /score="32.1465401" /energy="-16.5" /TU="U290" /idTUdmin="U290" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" CDS complement(411923..412036) /gene="yczN" /locus_tag="BSU_03789" /old_locus_tag="BSU03789" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 21670523; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative spore and germination protein" /protein_id="YP_003097677.1" /db_xref="EnsemblGenomes-Gn:BSU03789" /db_xref="EnsemblGenomes-Tr:CAX52548" /db_xref="GOA:C0H3V1" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/Swiss-Prot:C0H3V1" /translation="MSGYSNGGGYGGISSFALIVVLFILLIIVGTAFVGGF*" /label="yczN CDS" gene complement(411923..412036) /gene="yczN" /locus_tag="BSU_03789" /old_locus_tag="BSU03789" /label="yczN gene" promotor_-10 complement(412057..412076) /Source="Nicolas_upshift_promotors" /id="U290" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1406 /SigmaFactorBS="attcttcattttttctcttgtccactattaTCCCTGCCAAat ggatcggttcAGCATATCTTATAGTATCCTtcatagggaggtgaaaccttatgtcagg a" /listShort="yczN, yczM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(412068) /Source="Nicolas_upshifts" /id="U290" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1406 /SigmaFactorBS="attcttcattttttctcttgtccactattaTCCCTGCCAAat ggatcggttcAGCATATCTTATAGTATCCTtcatagggaggtgaaaccttatgtcagg a" /listShort="yczN, yczM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(412089..412098) /Source="Nicolas_upshift_promotors" /id="U290" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1406 /SigmaFactorBS="attcttcattttttctcttgtccactattaTCCCTGCCAAat ggatcggttcAGCATATCTTATAGTATCCTtcatagggaggtgaaaccttatgtcagg a" /listShort="yczN, yczM" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(412190..413554) /gene="thrD" /locus_tag="BSU_03790" /old_locus_tag="BSU03790" /EC_number="2.7.2.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2152900, 11471740, 27260660" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2152900, 11471740, 27260660; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aspartate kinase III" /protein_id="NP_388261.1" /db_xref="EnsemblGenomes-Gn:BSU03790" /db_xref="EnsemblGenomes-Tr:CAB12187" /db_xref="GOA:P94417" /db_xref="InterPro:IPR001048" /db_xref="InterPro:IPR001341" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR005260" /db_xref="InterPro:IPR018042" /db_xref="InterPro:IPR027795" /db_xref="InterPro:IPR035804" /db_xref="InterPro:IPR036393" /db_xref="SubtiList:BG12033" /db_xref="UniProtKB/Swiss-Prot:P94417" /translation="MKVVKFGGSSLASGAQLDKVFHIVTSDPARKAVVVSAPGKHYAE DTKVTDLLIACAEQYLATGSAPELAEAVVERYALIANELQLGQSIIEKIRDDLFTLLE GDKSNPEQYLDAVKASGEDNNAKLIAAYFRYKGVKAEYVNPKDAGLFVTNEPGNAQVL PESYQNLYRLRERDGLIIFPGFFGFSKDGDVITFSRSGSDITGSILANGLQADLYENF TDVDAVYSVNPSFVENPKEISELTYREMRELSYAGFSVFHDEALIPAFRAGIPVQIKN TNNPSAEGTRVVSKRDNTNGPVVGIASDTGFCSIYISKYLMNREIGFGRRALQILEEH GLTYEHVPSGIDDMTIILRQGQMDAATERSVIKRIEEDLHADEVIVEHHLALIMVVGE AMRHNVGTTARAAKALSEAQVNIEMINQGSSEVSMMFGVKEAEERKAVQALYQEFFAG VLIS*" /label="thrD CDS" gene complement(412190..413554) /gene="thrD" /locus_tag="BSU_03790" /old_locus_tag="BSU03790" /label="thrD gene" downshifts complement(412198) /Source="Nicolas_upshifts" /id="D167" /incds=0 /nref=23 /ntot=129 /MaxReadThrough="2.21842" /MaxDrop="4.81019" /score="44.9085917" /energy="-15" /TU="NA" /idTUdmin="U291" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(412242) /Source="Nicolas_upshifts" /id="D168" /incds=0 /nref=1 /ntot=17 /MaxReadThrough="5.53807" /MaxDrop="2.54279" /score="44.9085917" /energy="-15" /TU="U291" /idTUdmin="U291" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(413590..413609) /Source="Nicolas_upshift_promotors" /id="U291" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.946053946053946" /psig="0.999000999001" /xcortree=3042 /SigmaFactorBS="aaaaatacaaatgttctcctgagaaagaaattcccCCTTGAT TtacagtactgaaagAGAGATAATAAATACTAAATttgtgtgaaaattttaaacatta g" /listShort="yclM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(413606) /Source="Nicolas_upshifts" /id="U291" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.946053946053946" /psig="0.999000999001" /xcortree=3042 /SigmaFactorBS="aaaaatacaaatgttctcctgagaaagaaattcccCCTTGAT TtacagtactgaaagAGAGATAATAAATACTAAATttgtgtgaaaattttaaacatta g" /listShort="yclM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(413624..413631) /Source="Nicolas_upshift_promotors" /id="U291" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.946053946053946" /psig="0.999000999001" /xcortree=3042 /SigmaFactorBS="aaaaatacaaatgttctcctgagaaagaaattcccCCTTGAT TtacagtactgaaagAGAGATAATAAATACTAAATttgtgtgaaaattttaaacatta g" /listShort="yclM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 413745..413749 /Source="Nicolas_upshift_promotors" /id="U292" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.843156843156843" /psig="0.997002997002997" /xcortree=2746 /SigmaFactorBS="aaatatggtaaacagcctaacgttttggGATGGaaaatggtt agaatgATTAGTAAAATTGATAAATGactaggttaatatttttaaagaatattgacta a" /listShort="S130, yclN, yclO, yclP, yclQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 413765..413784 /Source="Nicolas_upshift_promotors" /id="U292" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.843156843156843" /psig="0.997002997002997" /xcortree=2746 /SigmaFactorBS="aaatatggtaaacagcctaacgttttggGATGGaaaatggtt agaatgATTAGTAAAATTGATAAATGactaggttaatatttttaaagaatattgacta a" /listShort="S130, yclN, yclO, yclP, yclQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 413777 /Source="Nicolas_upshifts" /id="U292" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.843156843156843" /psig="0.997002997002997" /xcortree=2746 /SigmaFactorBS="aaatatggtaaacagcctaacgttttggGATGGaaaatggtt agaatgATTAGTAAAATTGATAAATGactaggttaatatttttaaagaatattgacta a" /listShort="S130, yclN, yclO, yclP, yclQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 413808..413815 /Source="Nicolas_upshift_promotors" /id="U293" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2099 /SigmaFactorBS="ataaatgactaggttaatatttttaaagaaTATTGACTaacc ctataaaaaTGGTAATATGTAAATGATAAtgataatcaattactatatggccatattg t" /listShort="S130, yclN, yclO, yclP, yclQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 413829..413848 /Source="Nicolas_upshift_promotors" /id="U293" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2099 /SigmaFactorBS="ataaatgactaggttaatatttttaaagaaTATTGACTaacc ctataaaaaTGGTAATATGTAAATGATAAtgataatcaattactatatggccatattg t" /listShort="S130, yclN, yclO, yclP, yclQ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 413838..413938 /Source="Nicolas_S_feature" /locus_tag="new_432271_432371" /HighExp="LBGexp, Lbexp, G150, dia0, G135, H2O2, Paraq, dia15, G180, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S130" upshifts 413838 /Source="Nicolas_upshifts" /id="U293" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2099 /SigmaFactorBS="ataaatgactaggttaatatttttaaagaaTATTGACTaacc ctataaaaaTGGTAATATGTAAATGATAAtgataatcaattactatatggccatattg t" /listShort="S130, yclN, yclO, yclP, yclQ" /GFF_Attribute="listLong" /label="upshifts" CDS 413939..414889 /gene="pbtN" /locus_tag="BSU_03800" /old_locus_tag="BSU03800" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16850406, 19955416" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16850406, 19955416; Product type t: transporter" /codon_start=1 /transl_table=11 /product="petrobactin iron-siderophore ABC transporter (permease)" /protein_id="NP_388262.1" /db_xref="EnsemblGenomes-Gn:BSU03800" /db_xref="EnsemblGenomes-Tr:CAB12188" /db_xref="GOA:P94418" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12034" /db_xref="UniProtKB/Swiss-Prot:P94418" /translation="MKLRYLFILLIILAVTSVFIGVEDLSPLDLFDLSKQEASTLFAS RLPRLISIVIAGLSMSICGLIMQQISRNKFVSPTTAGTMDWARLGILISLLLFTSASP LIKMLVAFVFALAGNFLFMKILERIKFNDTIFIPLVGLMLGNIVSSIATFIAYKYDLI QNVSSWLQGDFSLVVKGRYELLYLSIPLVIIAYVYADKFTLAGMGESFSVNLGLKYKR VVNIGLIIVSLITSLVILTVGMLPFLGLIIPNIVSIYRGDNLKSSLPHTVLLGAVFVL FCDILGRIIIFPYEISIGLMVGIIGSGIFLFMLLRRKAYA*" /label="pbtN CDS" gene 413939..414889 /gene="pbtN" /locus_tag="BSU_03800" /old_locus_tag="BSU03800" /label="pbtN gene" CDS 414882..415829 /gene="pbtO" /locus_tag="BSU_03810" /old_locus_tag="BSU03810" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16850406, 19955416" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16850406, 19955416; Product type t: transporter" /codon_start=1 /transl_table=11 /product="petrobactin iron-siderophore ABC transporter (permease)" /protein_id="NP_388263.1" /db_xref="EnsemblGenomes-Gn:BSU03810" /db_xref="EnsemblGenomes-Tr:CAB12189" /db_xref="GOA:P94419" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12035" /db_xref="UniProtKB/Swiss-Prot:P94419" /translation="MRNQMKIALLVGLAIVCIGLFLFYDLGNWDYTLPRRIKKVAAIV LTGGAIAFSTMIFQTITNNRILTPSILGLDSLYMLIQTGIIFLFGSANMVIMNKNINF IISVLLMILFSLVLYQIMFKGEGRNIFFLLLIGIVFGTLFSSLSSFMQMLIDPNEFQV VQDKMFASFNNINTDLLWLAFIIFLLTGVYVWRFTKFFDVLSLGREHAVNLGIDYDKV VKQMLIVVAILVSVSTALVGPIMFLGLLVVNLAREFLKTYKHSYLIAGSVFISIIALV GGQFVVEKVFTFSTTLSVIINFAGGIYFIYLLLKENKSW*" /label="pbtO CDS" gene 414882..415829 /gene="pbtO" /locus_tag="BSU_03810" /old_locus_tag="BSU03810" /label="pbtO gene" CDS 415823..416581 /gene="pbtP" /locus_tag="BSU_03820" /old_locus_tag="BSU03820" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 19955416" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 19955416; Product type t: transporter" /codon_start=1 /transl_table=11 /product="petrobactin iron-siderophore ABC transporter (ATP-binding protein)" /protein_id="NP_388264.1" /db_xref="EnsemblGenomes-Gn:BSU03820" /db_xref="EnsemblGenomes-Tr:CAB12190" /db_xref="GOA:P94420" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12036" /db_xref="UniProtKB/Swiss-Prot:P94420" /translation="MVEVRNVSKQYGGKVVLEETSVTIQKGKITSFIGPNGAGKSTLL SIMSRLIKKDSGEIYIDGQEIGACDSKELAKKMSILKQANQINIRLTIKDLVSFGRFP YSQGRLTEEDWVHINQALSYMKLEDIQDKYLDQLSGGQCQRAFIAMVIAQDTDYIFLD EPLNNLDMKHSVEIMKLLKRLVEELGKTIVIVIHDINFASVYSDYIVALKNGRIVKEG PPEEMIETSVLEEIYDMTIPIQTIDNQRIGVYFS*" /label="pbtP CDS" gene 415823..416581 /gene="pbtP" /locus_tag="BSU_03820" /old_locus_tag="BSU03820" /label="pbtP gene" CDS 416603..417556 /gene="pbtQ" /locus_tag="BSU_03830" /old_locus_tag="BSU03830" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 19955416, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 19955416, 25355936; Product type t: transporter" /codon_start=1 /transl_table=11 /product="petrobactin iron-siderophore ABC transporter (binding lipoprotein)" /protein_id="NP_388265.1" /db_xref="EnsemblGenomes-Gn:BSU03830" /db_xref="EnsemblGenomes-Tr:CAB12191" /db_xref="GOA:P94421" /db_xref="InterPro:IPR002491" /db_xref="InterPro:IPR033870" /db_xref="PDB:3GFV" /db_xref="SubtiList:BG12037" /db_xref="UniProtKB/Swiss-Prot:P94421" /translation="MKKFALLFIALVTAVVISACGNQSTSSKGSDTKKEQITVKHQLD KNGTKVPKNPKKVVVFDFGSLDTLDKLGLDDIVAGLPKQVLPKYLSKFKDDKYADVGS LKEPDFDKVAELDPDLIIISARQSESYKEFSKIAPTIYLGVDTAKYMESFKSDAETIG KIFDKEDKVKDELANIDHSIADVKKTAEKLNKNGLVIMANDGKISAFGPKSRYGLIHD VFGVAPADQNIKASTHGQSVSYEYISKTNPDYLFVIDRGTAIGETSSTKQVVENDYVK NVNAVKNGHVIYLDSATWYLSGGGLESMTQMIKEVKDGLEK*" /label="pbtQ CDS" gene 416603..417556 /gene="pbtQ" /locus_tag="BSU_03830" /old_locus_tag="BSU03830" /label="pbtQ gene" downshifts 417539 /Source="Nicolas_upshifts" /id="D169" /incds=0 /nref=161 /ntot=280 /MaxReadThrough="3.87669" /MaxDrop="7.4722" /score="31.9942335" /energy="-13.8" /TU="U293" /idTUdmin="U292" /TUdmin=5 /isTUend="TRUE" /label="downshifts" CDS complement(417603..419021) /gene="ycnB" /locus_tag="BSU_03840" /old_locus_tag="BSU03840" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 15855514, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388266.1" /db_xref="EnsemblGenomes-Gn:BSU03840" /db_xref="EnsemblGenomes-Tr:CAB12192" /db_xref="GOA:P94422" /db_xref="InterPro:IPR004638" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12038" /db_xref="UniProtKB/Swiss-Prot:P94422" /translation="MNTSIEQKPFNRSVIVGILLAGAFVAILNQTLLITALPHIMRDF NVDANQAQWLTTSFMLTNGILIPITAFLIEKFTSRALLITAMSIFTAGTVVGAFAPNF PVLLTARIIQAAGAGIMMPLMQTVFLTIFPIEKRGQAMGMVGLVISFAPAIGPTLSGW AVEAFSWRSLFYIILPFAVIDLILASILMKNVTTLRKTQIDILSVILSTFGFGGLLYG FSSVGSYGWSSSTVLISLLVGVIALLLFITRQMKLKKPMLEFRVFTFGVFSLTTLLGT LVFALLIGTETILPLYTQNVRDVTAFDTGLMLLPGAVVMGFMSPIIGRIFDRVGGRGL AIAGFCIIFLTSLPFMQLTDHTSLAWIVVLYTVRLLGTAMIMMPVTTAGINALPRHLI PHGTAMNNTIRQVGGSIGTALLVSVMSNQAAHAGTTNVKHAALHGMNAAFIVAAVIAL VGFLLSFTLKKPQRPAEQQPAR*" /label="ycnB CDS" gene complement(417603..419021) /gene="ycnB" /locus_tag="BSU_03840" /old_locus_tag="BSU03840" /label="ycnB gene" downshifts complement(417624) /Source="Nicolas_upshifts" /id="D170" /incds=0 /nref=8 /ntot=150 /MaxReadThrough="2.00954" /MaxDrop="5.13029" /score="17.5501827" /energy="-13.8" /TU="NA" /idTUdmin="U294" /TUdmin="-14" /isTUend="TRUE" /label="downshifts" CDS complement(419041..419919) /gene="ycnC" /locus_tag="BSU_03850" /old_locus_tag="BSU03850" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (TetR/AcrR family)" /protein_id="NP_388267.2" /db_xref="EnsemblGenomes-Gn:BSU03850" /db_xref="EnsemblGenomes-Tr:CAB12193" /db_xref="GOA:P94423" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="SubtiList:BG12039" /db_xref="UniProtKB/Swiss-Prot:P94423" /translation="MLDKKTDILLAARKLFSEKDFTSVSMQAIAEECKMSKASIYKLF QSKEDLLLELLSFNQKQMVAAASRLQENTALTPEERLTQKVKMELEGFRRNQQFFNML TYGNPKLHNDRVKQHIHQTRSTIICWHRDSLIQAYGETILPFVWDLVIILHGMMREFL MLIKIEEKPLELDPIAEFIISTLNQIIKNRETRQSLLPPEAIELYIHSASSYKPKDKS VLLSESLKELHKGISSLSAADYDVDELTSAAAMLEEEAKKEEPRAFLLKSLIGYLEQT GVLTQPVSMLKTLLIT*" /label="ycnC CDS" gene complement(419041..419919) /gene="ycnC" /locus_tag="BSU_03850" /old_locus_tag="BSU03850" /label="ycnC gene" S_feature complement(419920..419986) /Source="Nicolas_S_feature" /locus_tag="new_438353_438419_c" /HighExp="dia15, H2O2, Diami, Paraq, Oxctl, Cold, G180, Salt, BMM, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S131" promotor_-10 complement(419985..420004) /Source="Nicolas_upshift_promotors" /id="U294" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.373626373626374" /psig="0.999000999001" /xcortree=2489 /SigmaFactorBS="gcaggcctttcatttacccggttaaaatcCATTGACttctat tttgtttaTCTGGTAAAATTTTTTCATTgttactcattggttttctgtgaaccaatgg g" /listShort="S131, ycnC, ycnB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(419994) /Source="Nicolas_upshifts" /id="U294" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.373626373626374" /psig="0.999000999001" /xcortree=2489 /SigmaFactorBS="gcaggcctttcatttacccggttaaaatcCATTGACttctat tttgtttaTCTGGTAAAATTTTTTCATTgttactcattggttttctgtgaaccaatgg g" /listShort="S131, ycnC, ycnB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(420019..420025) /Source="Nicolas_upshift_promotors" /id="U294" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.373626373626374" /psig="0.999000999001" /xcortree=2489 /SigmaFactorBS="gcaggcctttcatttacccggttaaaatcCATTGACttctat tttgtttaTCTGGTAAAATTTTTTCATTgttactcattggttttctgtgaaccaatgg g" /listShort="S131, ycnC, ycnB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(420083..420832) /gene="nfrAB" /locus_tag="BSU_03860" /old_locus_tag="BSU03860" /EC_number="1.5.1.39" /EC_number="1.6.99.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16229462, 9836433, 20862523" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16229462, 9836433, 20862523; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADPH-FMN oxidoreductase (nitroreductase)" /protein_id="NP_388268.1" /db_xref="EnsemblGenomes-Gn:BSU03860" /db_xref="EnsemblGenomes-Tr:CAB12194" /db_xref="GOA:P94424" /db_xref="InterPro:IPR000415" /db_xref="InterPro:IPR016446" /db_xref="InterPro:IPR029479" /db_xref="PDB:1ZCH" /db_xref="SubtiList:BG12040" /db_xref="UniProtKB/Swiss-Prot:P94424" /translation="MNEVIKSLTDHRSIRSYTDEPVAQEQLDQIIEAVQSAPSSINGQ QVTVITVQDKERKKKISELAGGQPWIDQAPVFLLFCADFNRAKIALEDLHDFKMEITN GLESVLVGAVDAGIALGTATAAAESLGLGTVPIGAVRGNPQELIELLELPKYVFPLSG LVIGHPADRSAKKPRLPQEAVNHQETYLNQDELTSHIQAYDEQMSEYMNKRTNGKETR NWSQSIASYYERLYYPHIREMLEKQGFKVEK*" /label="nfrAB CDS" gene complement(420083..420832) /gene="nfrAB" /locus_tag="BSU_03860" /old_locus_tag="BSU03860" /label="nfrAB gene" downshifts complement(420096) /Source="Nicolas_upshifts" /id="D171" /incds=0 /nref=136 /ntot=243 /MaxReadThrough="2.08639" /MaxDrop="5.10745" /score="11.1864402" /energy="-18.6" /TU="NA" /idTUdmin="U296" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(420849..421136) /gene="ycnE" /locus_tag="BSU_03870" /old_locus_tag="BSU03870" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17274596, 21454635; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative AI-2 degrading enzyme" /protein_id="NP_388269.1" /db_xref="EnsemblGenomes-Gn:BSU03870" /db_xref="EnsemblGenomes-Tr:CAB12195" /db_xref="GOA:P94425" /db_xref="InterPro:IPR007138" /db_xref="InterPro:IPR011008" /db_xref="SubtiList:BG12041" /db_xref="UniProtKB/Swiss-Prot:P94425" /translation="MIVLQAYIKVKPEKREEFLSEAQSLVQHSRAEEGNAQYDLFEKV GEENTFVMLEKWKDEAAMKFHNETAHFQGFVAKGKELLSAPLDVVRTELSE*" /label="ycnE CDS" gene complement(420849..421136) /gene="ycnE" /locus_tag="BSU_03870" /old_locus_tag="BSU03870" /label="ycnE gene" promotor_-35 421102..421109 /Source="Nicolas_upshift_promotors" /id="U295" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.966033966033966" /psig="0.993006993006993" /xcortree=1982 /SigmaFactorBS="aaaattcctcgcgtttttctGGTTTTACtttgatgtaagctT GTAATACGATCATGTAAATctcctccgtcgttatgcgaatttattgttcgaatttcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 421123..421142 /Source="Nicolas_upshift_promotors" /id="U295" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.966033966033966" /psig="0.993006993006993" /xcortree=1982 /SigmaFactorBS="aaaattcctcgcgtttttctGGTTTTACtttgatgtaagctT GTAATACGATCATGTAAATctcctccgtcgttatgcgaatttattgttcgaatttcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 421142 /Source="Nicolas_upshifts" /id="U295" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.966033966033966" /psig="0.993006993006993" /xcortree=1982 /SigmaFactorBS="aaaattcctcgcgtttttctGGTTTTACtttgatgtaagctT GTAATACGATCATGTAAATctcctccgtcgttatgcgaatttattgttcgaatttcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(421180..421199) /Source="Nicolas_upshift_promotors" /id="U296" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=1945 /SigmaFactorBS="acaattagaatgacaattttactatataagggttttTCCTTT ACctcatttagaataCATGTTACATTTAGTTCGATgaaattcgaacaataaattcgca t" /listShort="ycnE, ycnD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(421196) /Source="Nicolas_upshifts" /id="U296" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=1945 /SigmaFactorBS="acaattagaatgacaattttactatataagggttttTCCTTT ACctcatttagaataCATGTTACATTTAGTTCGATgaaattcgaacaataaattcgca t" /listShort="ycnE, ycnD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(421213..421220) /Source="Nicolas_upshift_promotors" /id="U296" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=1945 /SigmaFactorBS="acaattagaatgacaattttactatataagggttttTCCTTT ACctcatttagaataCATGTTACATTTAGTTCGATgaaattcgaacaataaattcgca t" /listShort="ycnE, ycnD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 421241..421248 /Source="Nicolas_upshift_promotors" /id="U297" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.614385614385614" /psig="0.955044955044955" /xcortree=576 /SigmaFactorBS="taacatgtattctaaatgaggtaaaggaaaaacccttatata gtaaaaTTGTCATTctaattgttgTATGATACATTTGTGTCATGaacattccaaacca t" /listShort="yczG" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 421253 /Source="Nicolas_upshifts" /id="U297" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.614385614385614" /psig="0.955044955044955" /xcortree=576 /SigmaFactorBS="taacatgtattctaaatgaggtaaaggaaaaacccttatata gtaaaaTTGTCATTctaattgttgTATGATACATTTGTGTCATGaacattccaaacca t" /listShort="yczG" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 421259..421278 /Source="Nicolas_upshift_promotors" /id="U297" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.614385614385614" /psig="0.955044955044955" /xcortree=576 /SigmaFactorBS="taacatgtattctaaatgaggtaaaggaaaaacccttatata gtaaaaTTGTCATTctaattgttgTATGATACATTTGTGTCATGaacattccaaacca t" /listShort="yczG" /GFF_Attribute="listLong" /label="promotor_-10" CDS 421276..421590 /gene="yczG" /locus_tag="BSU_03880" /old_locus_tag="BSU03880" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (ArsR family)" /protein_id="NP_388270.1" /db_xref="EnsemblGenomes-Gn:BSU03880" /db_xref="EnsemblGenomes-Tr:CAB12196" /db_xref="GOA:O31480" /db_xref="InterPro:IPR001845" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12781" /db_xref="UniProtKB/Swiss-Prot:O31480" /translation="MNIPNHPETETLQLTKVLHALSDPLRLELVKQLAEAKEKTCSTC ADVQVAKSTLSHHFKVLRESGIAQVRIEGKRRYYSLRAEDLEKAFPGLLEAVLNVDQD RW*" /label="yczG CDS" gene 421276..421590 /gene="yczG" /locus_tag="BSU_03880" /old_locus_tag="BSU03880" /label="yczG gene" downshifts 421582 /Source="Nicolas_upshifts" /id="D172" /incds=0 /nref=173 /ntot=262 /MaxReadThrough="0.52252" /MaxDrop="5.32898" /score="20.7855667" /energy="-7.4" /TU="NA" /idTUdmin="U297" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(421592..423031) /gene="gabR" /locus_tag="BSU_03890" /old_locus_tag="BSU03890" /experiment="publication(s) with functional evidences, PMID:15223311, 24127574, 25388514, 27640111, 28348215, 28412355" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15223311, 24127574, 25388514, 27640111, 28348215, 28412355; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (GntR/MocR family) with PLP binding site (GabR-GABA-PLP aldimine)" /protein_id="NP_388271.1" /db_xref="EnsemblGenomes-Gn:BSU03890" /db_xref="EnsemblGenomes-Tr:CAB12197" /db_xref="GOA:P94426" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:4MGR" /db_xref="PDB:4N0B" /db_xref="PDB:4TV7" /db_xref="PDB:5T4J" /db_xref="PDB:5T4K" /db_xref="PDB:5X03" /db_xref="SubtiList:BG12042" /db_xref="UniProtKB/Swiss-Prot:P94426" /translation="MDITITLDRSEQADYIYQQIYQKLKKEILSRNLLPHSKVPSKRE LAENLKVSVNSVNSAYQQLLAEGYLYAIERKGFFVEELDMFSAEEHPPFALPDDLKEI HIDQSDWISFSHMSSDTDHFPIKSWFRCEQKAASRSYRTLGDMSHPQGIYEVRAAITR LISLTRGVKCRPEQMIIGAGTQVLMQLLTELLPKEAVYAMEEPGYRRMYQLLKNAGKQ VKTIMLDEKGMSIAEITRQQPDVLVTTPSHQFPSGTIMPVSRRIQLLNWAAEEPRRYI IEDDYDSEFTYDVDSIPALQSLDRFQNVIYMGTFSKSLLPGLRISYMVLPPELLRAYK QRGYDLQTCSSLTQLTLQEFIESGEYQKHIKKMKQHYKEKRERLITALEAEFSGEVTV KGANAGLHFVTEFDTRRTEQDILSHAAGLQLEIFGMSRFNLKENKRQTGRPALIIGFA RLKEEDIQEGVQRLFKAVYGHKKIPVTGD*" /label="gabR CDS" gene complement(421592..423031) /gene="gabR" /locus_tag="BSU_03890" /old_locus_tag="BSU03890" /label="gabR gene" promotor_-10 complement(421916..421927) /Source="Nicolas_upshift_promotors" /id="U298" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=919 /SigmaFactorBS="cctgcaggaatttatcgagtctggtgaatatcagaAGCATAT aaaaaaaatgaagCAGCATTATAAAgaaaagagagaacgcctgatcaccgctttagaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(421922) /Source="Nicolas_upshifts" /id="U298" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=919 /SigmaFactorBS="cctgcaggaatttatcgagtctggtgaatatcagaAGCATAT aaaaaaaatgaagCAGCATTATAAAgaaaagagagaacgcctgatcaccgctttagaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(421941..421947) /Source="Nicolas_upshift_promotors" /id="U298" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=919 /SigmaFactorBS="cctgcaggaatttatcgagtctggtgaatatcagaAGCATAT aaaaaaaatgaagCAGCATTATAAAgaaaagagagaacgcctgatcaccgctttagaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(423074..423093) /Source="Nicolas_upshift_promotors" /id="U299" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.728271728271728" /psig="0.999000999001" /xcortree=2992 /SigmaFactorBS="tcatgtgaatatccccctgtcggtattttcTTATCATTctga cttctcTTTGGTATGATGAAAAGTACcaattataactttttgatggtatcagaaggag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 423075..423082 /Source="Nicolas_upshift_promotors" /id="U300" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.537462537462537" /psig="0.942057942057942" /xcortree=377 /SigmaFactorBS="ttctccttctgataccatcaaaaagttataattggTACTTTT CatcataccaaagaGAAGTCAGAATGATAAGAAAataccgacagggggatattcacat g" /listShort="gabT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(423081) /Source="Nicolas_upshifts" /id="U299" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.728271728271728" /psig="0.999000999001" /xcortree=2992 /SigmaFactorBS="tcatgtgaatatccccctgtcggtattttcTTATCATTctga cttctcTTTGGTATGATGAAAAGTACcaattataactttttgatggtatcagaaggag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 423096..423115 /Source="Nicolas_upshift_promotors" /id="U300" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.537462537462537" /psig="0.942057942057942" /xcortree=377 /SigmaFactorBS="ttctccttctgataccatcaaaaagttataattggTACTTTT CatcataccaaagaGAAGTCAGAATGATAAGAAAataccgacagggggatattcacat g" /listShort="gabT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 423100 /Source="Nicolas_upshifts" /id="U300" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.537462537462537" /psig="0.942057942057942" /xcortree=377 /SigmaFactorBS="ttctccttctgataccatcaaaaagttataattggTACTTTT CatcataccaaagaGAAGTCAGAATGATAAGAAAataccgacagggggatattcacat g" /listShort="gabT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(423104..423111) /Source="Nicolas_upshift_promotors" /id="U299" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.728271728271728" /psig="0.999000999001" /xcortree=2992 /SigmaFactorBS="tcatgtgaatatccccctgtcggtattttcTTATCATTctga cttctcTTTGGTATGATGAAAAGTACcaattataactttttgatggtatcagaaggag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 423138..424448 /gene="gabT" /locus_tag="BSU_03900" /old_locus_tag="BSU03900" /EC_number="2.6.1.19" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:4590473, 12123465, 12354229, 15590624, 9723923, 19854901, 24529384" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4590473, 12123465, 12354229, 15590624, 9723923, 19854901, 24529384; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-aminobutyrate aminotransferase" /protein_id="NP_388272.1" /db_xref="EnsemblGenomes-Gn:BSU03900" /db_xref="EnsemblGenomes-Tr:CAB12198" /db_xref="GOA:P94427" /db_xref="InterPro:IPR004632" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG12043" /db_xref="UniProtKB/Swiss-Prot:P94427" /translation="MSQTTASITTAQWQQKRDQFVSKGVSNGNRSLAVKGEGAELYDL DGRRFIDFAGAIGTLNVGHSHPKVVEAVKRQAEELIHPGFNVMMYPTYIELAEKLCGI APGSHEKKAIFLNSGAEAVENAVKIARKYTKRQGVVSFTRGFHGRTNMTMSMTSKVKP YKFGFGPFAPEVYQAPFPYYYQKPAGMSDESYDDMVIQAFNDFFIASVAPETVACVVM EPVQGEGGFIIPSKRFVQHVASFCKEHGIVFVADEIQTGFARTGTYFAIEHFDVVPDL ITVSKSLAAGLPLSGVIGRAEMLDAAAPGELGGTYAGSPLGCAAALAVLDIIEEEGLN ERSEEIGKIIEDKAYEWKQEFPFIGDIRRLGAMAAIEIVKDPDTREPDKTKAAAIAAY ANQNGLLLLTAGINGNIIRFLTPLVISDSLLNEGLSILEAGLRA*" /label="gabT CDS" gene 423138..424448 /gene="gabT" /locus_tag="BSU_03900" /old_locus_tag="BSU03900" /label="gabT gene" promotor_-35 424326..424332 /Source="Nicolas_upshift_promotors" /id="U301" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=250 /SigmaFactorBS="cagcagcgatcgcggcctatgcgaatcaaaacGGATTACttt tgctgacagcGGGAATTAACGGTAATATCatccgctttttgacaccgctcgtcatctc a" /listShort="gabD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 424346..424364 /Source="Nicolas_upshift_promotors" /id="U301" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=250 /SigmaFactorBS="cagcagcgatcgcggcctatgcgaatcaaaacGGATTACttt tgctgacagcGGGAATTAACGGTAATATCatccgctttttgacaccgctcgtcatctc a" /listShort="gabD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 424354 /Source="Nicolas_upshifts" /id="U301" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=250 /SigmaFactorBS="cagcagcgatcgcggcctatgcgaatcaaaacGGATTACttt tgctgacagcGGGAATTAACGGTAATATCatccgctttttgacaccgctcgtcatctc a" /listShort="gabD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 424450..424457 /Source="Nicolas_upshift_promotors" /id="U302" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig="0.998001998001998" /xcortree=2034 /SigmaFactorBS="catcttggaggcgggcctgcgagcttaatCATTGGAAagaaa atggccgggTCTGCTATCATTTTAAGTAAtcatgaaaagaaaggaatgttcaatatgc c" /listShort="gabD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 424472..424491 /Source="Nicolas_upshift_promotors" /id="U302" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig="0.998001998001998" /xcortree=2034 /SigmaFactorBS="catcttggaggcgggcctgcgagcttaatCATTGGAAagaaa atggccgggTCTGCTATCATTTTAAGTAAtcatgaaaagaaaggaatgttcaatatgc c" /listShort="gabD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 424481 /Source="Nicolas_upshifts" /id="U302" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig="0.998001998001998" /xcortree=2034 /SigmaFactorBS="catcttggaggcgggcctgcgagcttaatCATTGGAAagaaa atggccgggTCTGCTATCATTTTAAGTAAtcatgaaaagaaaggaatgttcaatatgc c" /listShort="gabD" /GFF_Attribute="listLong" /label="upshifts" CDS 424517..425905 /gene="gabD" /locus_tag="BSU_03910" /old_locus_tag="BSU03910" /EC_number="1.2.1.24" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12354229, 15590624, 9723923, 12123465, 24529384, 24809290, 25911692" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15590624, 9723923, 12123465, 24529384, 24809290, 25911692; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="succinate-semialdehyde dehydrogenase" /protein_id="NP_388273.1" /db_xref="EnsemblGenomes-Gn:BSU03910" /db_xref="EnsemblGenomes-Tr:CAB12199" /db_xref="GOA:P94428" /db_xref="InterPro:IPR010102" /db_xref="InterPro:IPR012394" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="SubtiList:BG12044" /db_xref="UniProtKB/Swiss-Prot:P94428" /translation="MPDQLTVYNPATGEEIKTIPQQSATEVEEAIERSHQAFKTWSKT SANERTSLLKKWYELIVEHKEELADLITKENGKPYQEAVGEVLYGAGYIEWFAEEAKR VYGRTVPAPTTGKRIVVTRQPVGPVAAITPWNFPNAMITRKAAPALAAGCTFIIKPAP DTPLSAYELARLAYEAGIPKDVLQVVIGDGEEIGNVFTSSPKIRKITFTGSTPVGKIL MKNSADTVKHVSMELGGHAPLIVDEDADIDLAVEQAMASKYRNAGQTCVCANRLIVHE SIKDEFAAKLSEQVSKLKVGNGLEEGVNVGPIINKRGFEKIVSQIDDAVEKGAKVIAG GTYDRNDDKGCYFVNPTVLTDVDTSMNIMHEETFGPVAPIVTFSDIDEAIQLANDTPY GLAAYFFTENYRRGIYISENLEYGIIGWNDGGPSAVQAPFGGMKESGIGREGGSEGIE PYLETKYLSIGL*" /label="gabD CDS" gene 424517..425905 /gene="gabD" /locus_tag="BSU_03910" /old_locus_tag="BSU03910" /label="gabD gene" downshifts 425913 /Source="Nicolas_upshifts" /id="D173" /incds=0 /nref=107 /ntot=240 /MaxReadThrough="0.105510000000001" /MaxDrop="6.52053" /score="38.677658" /energy="-19.9" /TU="NA" /idTUdmin="U301" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" promotor_-35 425963..425969 /Source="Nicolas_upshift_promotors" /id="U303" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=885 /SigmaFactorBS="gagctgccggattttccggcagctctttttgtgttccggCGA ATAAtcacaacaattccAGCCAAAATAACagcaaatacattttgaaagaaggttcccc a" /listShort="glcU, gdh" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 425983..425994 /Source="Nicolas_upshift_promotors" /id="U303" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=885 /SigmaFactorBS="gagctgccggattttccggcagctctttttgtgttccggCGA ATAAtcacaacaattccAGCCAAAATAACagcaaatacattttgaaagaaggttcccc a" /listShort="glcU, gdh" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 425984 /Source="Nicolas_upshifts" /id="U303" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=885 /SigmaFactorBS="gagctgccggattttccggcagctctttttgtgttccggCGA ATAAtcacaacaattccAGCCAAAATAACagcaaatacattttgaaagaaggttcccc a" /listShort="glcU, gdh" /GFF_Attribute="listLong" /label="upshifts" CDS 426028..426891 /gene="glcU" /locus_tag="BSU_03920" /old_locus_tag="BSU03920" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10438764, 15849754, 16850406, 19054326, 21564334, 27329749; Product type t : transporter" /codon_start=1 /transl_table=11 /product="glucose uptake protein" /protein_id="NP_388274.1" /db_xref="EnsemblGenomes-Gn:BSU03920" /db_xref="EnsemblGenomes-Tr:CAB12200" /db_xref="GOA:P40420" /db_xref="InterPro:IPR010651" /db_xref="SubtiList:BG11066" /db_xref="UniProtKB/Swiss-Prot:P40420" /translation="MDLLLALLPALFWGSIVLFNVKLGGGPYSQTLGTTIGALIVSIV IYFFVQPVLSLRIFIVGIVSGLFWSLGQANQLKSIQLMGVSKTMPISTGMQLVSTSLF GVIVFREWSTPIAITLGVLALIFIIVGIILTSLEDKNDKKEGEPSNLKKGILILLVST LGYLVYVVVARLFNVSGWSALLPQAIGMVVGGLVLTYRHKPFNKYAIRNILPGLIWAG GNMFLFISQPRVGVATSFSLSQMGIVISTLGGIFILREKKTKRQLIAIAIGIILIIAA AVFLGIAKTNS*" /label="glcU CDS" gene 426028..426891 /gene="glcU" /locus_tag="BSU_03920" /old_locus_tag="BSU03920" /label="glcU gene" CDS 426911..427696 /gene="gdh" /locus_tag="BSU_03930" /old_locus_tag="BSU03930" /EC_number="1.1.1.47" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2493633, 3141376, 6438057, 16912926" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2493633, 3141376, 6438057, 16912926; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="forespore glucose 1-dehydrogenase" /protein_id="NP_388275.1" /db_xref="EnsemblGenomes-Gn:BSU03930" /db_xref="EnsemblGenomes-Tr:CAB12201" /db_xref="GOA:P12310" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10545" /db_xref="UniProtKB/Swiss-Prot:P12310" /translation="MYPDLKGKVVAITGAASGLGKAMAIRFGKEQAKVVINYYSNKQD PNEVKEEVIKAGGEAVVVQGDVTKEEDVKNIVQTAIKEFGTLDIMINNAGLENPVPSH EMPLKDWDKVIGTNLTGAFLGSREAIKYFVENDIKGNVINMSSVHEVIPWPLFVHYAA SKGGIKLMTETLALEYAPKGIRVNNIGPGAINTPINAEKFADPKQKADVESMIPMGYI GEPEEIAAVAAWLASKEASYVTGITLFADGGMTQYPSFQAGRG*" /label="gdh CDS" gene 426911..427696 /gene="gdh" /locus_tag="BSU_03930" /old_locus_tag="BSU03930" /label="gdh gene" misc_feature 427016..427035 /Source="Nicolas_upshift_promotors" /id="U304" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.692307692307692" /psig="0.732267732267732" /xcortree=1477 /SigmaFactorBS="gcttcagggctcggaaaggcgatggccattcgcttcggcaag gagcaggcaaaagtggttATCAACTATTATAGTAATAAacaagatccgaacgaggtaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 427016 /Source="Nicolas_upshifts" /id="U304" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.692307692307692" /psig="0.732267732267732" /xcortree=1477 /SigmaFactorBS="gcttcagggctcggaaaggcgatggccattcgcttcggcaag gagcaggcaaaagtggttATCAACTATTATAGTAATAAacaagatccgaacgaggtaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 427104 /Source="Nicolas_upshifts" /id="D174" /incds=1 /nref=1 /ntot=3 /MaxReadThrough="6.44884" /MaxDrop="2.47712" /score="-5.4075438" /energy="-11.7" /TU="U303" /idTUdmin="U301" /TUdmin=1188 /isTUend="FALSE" /label="downshifts" downshifts 427698 /Source="Nicolas_upshifts" /id="D175" /incds=0 /nref=4 /ntot=40 /MaxReadThrough="2.7861" /MaxDrop="4.2307" /score="-5.4075438" /energy="-11.7" /TU="U303" /idTUdmin="U303" /TUdmin="-836" /isTUend="FALSE" /label="downshifts" CDS complement(427741..428355) /gene="cutI" /locus_tag="BSU_03940" /old_locus_tag="BSU03940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19168619, 22904286, 27010565, 26822828; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative membrane protein involved in copper intake" /protein_id="NP_388276.1" /db_xref="EnsemblGenomes-Gn:BSU03940" /db_xref="EnsemblGenomes-Tr:CAB12202" /db_xref="GOA:P94431" /db_xref="InterPro:IPR012533" /db_xref="SubtiList:BG12045" /db_xref="UniProtKB/Swiss-Prot:P94431" /translation="MLKKIALTLCPAIVGSLLFFTAPASAHVSVKPAESAAGSWETYT MKVPSEKNLPTTKVVLKMPKDVEFQQYEPIPGWKVSTQKHDDKSVSVTWEATDGGIQE GQFQQFTFVAKNPDKAEEAAWDAYQYYKDGSIVEWTGDEDADTPHSITNITSAKQVTD EHGATKTEDDSENSGSSALDITAMVLSAAAIILSVAALVKKKRA*" /label="cutI CDS" gene complement(427741..428355) /gene="cutI" /locus_tag="BSU_03940" /old_locus_tag="BSU03940" /label="cutI gene" downshifts complement(427752) /Source="Nicolas_upshifts" /id="D176" /incds=0 /nref=95 /ntot=219 /MaxReadThrough="0.879290000000001" /MaxDrop="6.67627" /score="21.5633403" /energy="-16" /TU="NA" /idTUdmin="U305" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(428368..429993) /gene="cutJ" /locus_tag="BSU_03950" /old_locus_tag="BSU03950" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15101989, 15849754, 16850406, 19168619, 22904286, 23012364" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15101989, 15849754, 16850406, 19168619, 22904286, 23012364; Product type t : transporter" /codon_start=1 /transl_table=11 /product="copper import permease subunit" /protein_id="NP_388277.2" /db_xref="EnsemblGenomes-Gn:BSU03950" /db_xref="EnsemblGenomes-Tr:CAB12203" /db_xref="GOA:C0SP95" /db_xref="InterPro:IPR007348" /db_xref="InterPro:IPR008457" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR014756" /db_xref="InterPro:IPR032693" /db_xref="InterPro:IPR032694" /db_xref="SubtiList:BG12046" /db_xref="UniProtKB/Swiss-Prot:C0SP95" /translation="MKRNRWWIILLLFLVFLPKTSFAHAYIVKSSPGENSELKSAPAQ VEIEFNEPVEEGFHYIKVYNSNGDRVDTDKTEIKKDNHHIMTVKLKKNLPKDVYRAEW NAVSADGHPVSGVIPFSIGKADGGFSSQKAADSALNPGTAADRAILYTALSLFIGTVF FHLFWYKGKSEQLVKRTRRILTGSIAALGLALLLQLPIQTKANAGGGWGSAFQPGYIR ETLFETAGGSIWIIQAALFVLLALSVIPAIRKNRFSSFGYWTAPLIFFFGLLLAKAFT GHAAVVEEKTVGILMDFLHLTSASIWVGGIAALVLLLSKEWRQPDKTLAWETVRRFSP WALTAVGVILFSGLLNGFFIIRSMDSLFHTAYGQALLVKSGLFVFMLVLGAIHFLLTR KQRRTGISRTLKAEWAIGIAVLITAAVFTSLPSPPEPAPEPFYQTKAIENGQSVSLSI SPNQPGKNVFELRVTDHNGDPVKNIQQITLTVYKTGLSGSENKSTFTLKEKTKGVFQD QNLSINEKGNWKIKVHGLTGDFNEINIMFTKTN*" /label="cutJ CDS" gene complement(428368..429993) /gene="cutJ" /locus_tag="BSU_03950" /old_locus_tag="BSU03950" /label="cutJ gene" CDS complement(430028..430600) /gene="cutR" /locus_tag="BSU_03960" /old_locus_tag="BSU03960" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15101989, 22904286, 23012364" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15101989, 22904286, 23012364; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of copper intake (CutR-Cu(+))" /protein_id="NP_388278.1" /db_xref="EnsemblGenomes-Gn:BSU03960" /db_xref="EnsemblGenomes-Tr:CAB12204" /db_xref="GOA:P94433" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR008719" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12047" /db_xref="UniProtKB/Swiss-Prot:P94433" /translation="MLPINRQQHILKWLKEEGSLRISDISARFGVSEMTVYRDVNQLV QSNQVIKTAGGITLPVRTPQTDHMCSYCLKPVNQAHSVQLITVNQDIEQLCCAHCAFL RYADKTEEVSHLICRDFLLQTTVSAGSAYFVVNAELNLHCCQPQAIPFATLDHAERFQ KGFGGAVCTFDQALEDMLQDRKKRCTCTKK*" /label="cutR CDS" gene complement(430028..430600) /gene="cutR" /locus_tag="BSU_03960" /old_locus_tag="BSU03960" /label="cutR gene" promotor_-10 complement(430622..430641) /Source="Nicolas_upshift_promotors" /id="U305" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.944055944055944" /psig="0.999000999001" /xcortree=1591 /SigmaFactorBS="tgttcaacacattttcacattttttatcatccactTACTTGT CtccgtctctaaaaTCCTCTACGCTTAAATAGATcttaatgaagagggtgtatgaatg c" /listShort="ycnK, ycnJ, ycnI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(430637) /Source="Nicolas_upshifts" /id="U305" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.944055944055944" /psig="0.999000999001" /xcortree=1591 /SigmaFactorBS="tgttcaacacattttcacattttttatcatccactTACTTGT CtccgtctctaaaaTCCTCTACGCTTAAATAGATcttaatgaagagggtgtatgaatg c" /listShort="ycnK, ycnJ, ycnI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(430655..430662) /Source="Nicolas_upshift_promotors" /id="U305" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.944055944055944" /psig="0.999000999001" /xcortree=1591 /SigmaFactorBS="tgttcaacacattttcacattttttatcatccactTACTTGT CtccgtctctaaaaTCCTCTACGCTTAAATAGATcttaatgaagagggtgtatgaatg c" /listShort="ycnK, ycnJ, ycnI" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 430722..430741 /Source="Nicolas_upshift_promotors" /id="U306" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.764235764235764" /psig="0.999000999001" /xcortree=2504 /SigmaFactorBS="aaaaatgtgaaaatgtgttgaacagcaacaaaacgaaacaga agggacTCTGGTATAATAGACAGATGgaatagaaagtgaggaataccctatgaaagaa a" /listShort="ycnL" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 430734 /Source="Nicolas_upshifts" /id="U306" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.764235764235764" /psig="0.999000999001" /xcortree=2504 /SigmaFactorBS="aaaaatgtgaaaatgtgttgaacagcaacaaaacgaaacaga agggacTCTGGTATAATAGACAGATGgaatagaaagtgaggaataccctatgaaagaa a" /listShort="ycnL" /GFF_Attribute="listLong" /label="upshifts" CDS 430765..431118 /gene="ycnL" /locus_tag="BSU_03970" /old_locus_tag="BSU03970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 18307109, 27010565; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative reductase or disulfide isomerase" /protein_id="NP_388279.1" /db_xref="EnsemblGenomes-Gn:BSU03970" /db_xref="EnsemblGenomes-Tr:CAB12205" /db_xref="GOA:P94434" /db_xref="SubtiList:BG12048" /db_xref="UniProtKB/Swiss-Prot:P94434" /translation="MKETPCPNCGKPLTGDMVRSSNVPCQFRCGHCRERLYEYKVSAP IMLVSLAAIVLLIYLLMLLRNAAGSVLPAVQHVPMAVFALVCAYPVFIVSERMIAKYV IQNGNIIYRGKRKGS*" /label="ycnL CDS" gene 430765..431118 /gene="ycnL" /locus_tag="BSU_03970" /old_locus_tag="BSU03970" /label="ycnL gene" downshifts 431089 /Source="Nicolas_upshifts" /id="D177" /incds=0 /nref=136 /ntot=248 /MaxReadThrough="0.860829999999999" /MaxDrop="6.25982" /score="38.4886131" /energy="-13.4" /TU="NA" /idTUdmin="U306" /TUdmin="-19" /isTUend="TRUE" /label="downshifts" promotor_-35 431182..431189 /Source="Nicolas_upshift_promotors" /id="U307" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1546 /SigmaFactorBS="tgtcacagtcatgtgccaaagtcctctttactttCAATTGTA tagggactgtaagCGTTTTAACATAGAGTCAAAgggaagcatcattctctgaacatat t" /listShort="S132, mtlA, mtlF, mtlD, ycsA, sipU, S133" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 431203..431222 /Source="Nicolas_upshift_promotors" /id="U307" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1546 /SigmaFactorBS="tgtcacagtcatgtgccaaagtcctctttactttCAATTGTA tagggactgtaagCGTTTTAACATAGAGTCAAAgggaagcatcattctctgaacatat t" /listShort="S132, mtlA, mtlF, mtlD, ycsA, sipU, S133" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 431208 /Source="Nicolas_upshifts" /id="U307" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1546 /SigmaFactorBS="tgtcacagtcatgtgccaaagtcctctttactttCAATTGTA tagggactgtaagCGTTTTAACATAGAGTCAAAgggaagcatcattctctgaacatat t" /listShort="S132, mtlA, mtlF, mtlD, ycsA, sipU, S133" /GFF_Attribute="listLong" /label="upshifts" S_feature 431218..431290 /Source="Nicolas_S_feature" /locus_tag="new_449651_449723" /HighExp="S0, dia5, Gly, G135, B60, T0.30H, BT, G180, G150, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S132" CDS 431291..432727 /gene="mtlA" /locus_tag="BSU_03981" /old_locus_tag="BSU03981" /EC_number="2.7.1.197" /function="16.1: Circulate" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12897001, 23279188" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12897001, 23279188; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) mannitol-specific enzyme IICB component" /protein_id="NP_388280.2" /db_xref="EnsemblGenomes-Gn:BSU03981" /db_xref="EnsemblGenomes-Tr:CAB12206" /db_xref="GOA:P42956" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR003501" /db_xref="InterPro:IPR004718" /db_xref="InterPro:IPR013011" /db_xref="InterPro:IPR013014" /db_xref="InterPro:IPR029503" /db_xref="InterPro:IPR036095" /db_xref="SubtiList:BG11215" /db_xref="UniProtKB/Swiss-Prot:P42956" /translation="MQQQEQQQGGMKVKVQRFGSYLSGMIMPNIGAFIAWGIITALFI PAGWFPNEQLNTLVSPMITYLLPLLIAYTGGKMIYDHRGGVVGATAAIGVIVGSDIPM FLGAMIMGPLGGYLIKQTDKLFKDKVKQGFEMLINNFTAGIVGAALTILAFYAIGPVV LTLNKLLAAGVEVIVHANLLPVASVFVEPAKVLFLNNAINHGILSPIGIEQASQTGKS ILFLVEANPGPGLGILLAYMFFGKGSSKSTAPGAAIIHFFGGIHEIYFPYILMKPALI LAAIAGGASGLLTFTIFNAGLVAAASPGSIIALMAMTPRGGYFGVLAGVLVAAAVSFI VSAVILKSSKASEEDLAAATEKMQSMKGKKSQAAAALEAEQAKAEEASELSPESVNKI IFACDAGMGSSAMGASILRNKVKKAELDISVTNTAINNLPSDADIVITHKDLTDRAKA KLPNATHISVDNFLNSPKYDELIEKLKK*" /label="mtlA CDS" gene 431291..432727 /gene="mtlA" /locus_tag="BSU_03981" /old_locus_tag="BSU03981" /label="mtlA gene" CDS 432752..433183 /gene="mtlF" /locus_tag="BSU_03982" /old_locus_tag="BSU03982" /EC_number="2.7.1.197" /function="16.1: Circulate" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12897001, 23279188" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12897001, 23279188; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) mannitol-specific enzyme IIA component" /protein_id="YP_003097678.1" /db_xref="EnsemblGenomes-Gn:BSU03982" /db_xref="EnsemblGenomes-Tr:CAX52549" /db_xref="GOA:C0H3V2" /db_xref="InterPro:IPR002178" /db_xref="InterPro:IPR016152" /db_xref="UniProtKB/Swiss-Prot:C0H3V2" /translation="MQVLAKENIKLNQTVSSKEEAIKLAGQTLIDNGYVTEDYISKMF EREETSSTFMGNFIAIPHGTEEAKSEVLHSGISIIQIPEGVEYGEGNTAKVVFGIAGK NNEHLDILSNIAIICSEEENIERLISAKSEEDLIAIFNEVN*" /label="mtlF CDS" gene 432752..433183 /gene="mtlF" /locus_tag="BSU_03982" /old_locus_tag="BSU03982" /label="mtlF gene" CDS 433185..434306 /gene="mtlD" /locus_tag="BSU_03990" /old_locus_tag="BSU03990" /EC_number="1.1.1.17" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12897001, 22014119, 23279188" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12897001, 22014119, 23279188; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="mannitol-1-phosphate 5-dehydrogenase" /protein_id="NP_388281.2" /db_xref="EnsemblGenomes-Gn:BSU03990" /db_xref="EnsemblGenomes-Tr:CAB12207" /db_xref="GOA:P42957" /db_xref="InterPro:IPR000669" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013118" /db_xref="InterPro:IPR013131" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR023027" /db_xref="InterPro:IPR023028" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11216" /db_xref="UniProtKB/Swiss-Prot:P42957" /translation="MIALHFGAGNIGRGFIGALLHHSGYDVVFADVNETMVSLLNEKK EYTVELAEEGRSSEIIGPVSAINSGSQTEELYRLMNEAALITTAVGPNVLKLIAPSIA EGLRRRNTANTLNIIACENMIGGSSFLKKEIYSHLTEAEQKSVSETVGFPNSAVDRIV PIQHHEDPLKVSVEPFFEWVIDESGFKGKTPVINGALFVDDLTPYIERKLFTVNTGHA VTAYVGYQRGLKTVKEAIDHPEIRRVVHSALLETGDYLVKSYGFKQTEHEQYIKKIIG RFENPFISDDVTRVARSPLRKLGENDRLVGPAKKIKEPNALAEGIAAALRFDFTGDPE AVELQALIEEKGYSGVLQEVCGIQSHEPLHAIILKKLNQ*" /label="mtlD CDS" gene 433185..434306 /gene="mtlD" /locus_tag="BSU_03990" /old_locus_tag="BSU03990" /label="mtlD gene" downshifts 434289 /Source="Nicolas_upshifts" /id="D178" /incds=0 /nref=46 /ntot=156 /MaxReadThrough="5.56503" /MaxDrop="4.72154" /score="32.3837677" /energy="-13.4" /TU="U307" /idTUdmin="U308" /TUdmin="-1254" /isTUend="FALSE" /label="downshifts" promotor_-35 434335..434338 /Source="Nicolas_upshift_promotors" /id="U308" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.964035964035964" /psig=1 /xcortree=1552 /SigmaFactorBS="ttaatcaataaccgaccacccgtgacacaatgtcacgggCTT TttttactatctcgcaATCTAGTATAATAGAAAGCGcttacgataacaggggaaggag a" /listShort="ycsA" /listLong="sipU, S133, ycsD" /label="promotor_-35" promotor_-10 434354..434373 /Source="Nicolas_upshift_promotors" /id="U308" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.964035964035964" /psig=1 /xcortree=1552 /SigmaFactorBS="ttaatcaataaccgaccacccgtgacacaatgtcacgggCTT TttttactatctcgcaATCTAGTATAATAGAAAGCGcttacgataacaggggaaggag a" /listShort="ycsA" /listLong="sipU, S133, ycsD" /label="promotor_-10" upshifts 434356 /Source="Nicolas_upshifts" /id="U308" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.964035964035964" /psig=1 /xcortree=1552 /SigmaFactorBS="ttaatcaataaccgaccacccgtgacacaatgtcacgggCTT TttttactatctcgcaATCTAGTATAATAGAAAGCGcttacgataacaggggaaggag a" /listShort="ycsA" /listLong="sipU, S133, ycsD" /label="upshifts" CDS 434397..435461 /gene="ycsA" /locus_tag="BSU_04000" /old_locus_tag="BSU04000" /EC_number="1.1.1.93" /EC_number="1.1.1.83" /EC_number="4.1.1.73" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10568751, 12356321; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative tartrate dehydrogenase" /protein_id="NP_388282.3" /db_xref="EnsemblGenomes-Gn:BSU04000" /db_xref="EnsemblGenomes-Tr:CAB12208" /db_xref="GOA:P42958" /db_xref="InterPro:IPR011829" /db_xref="InterPro:IPR019818" /db_xref="InterPro:IPR024084" /db_xref="SubtiList:BG11222" /db_xref="UniProtKB/Swiss-Prot:P42958" /translation="MTMKQFEIAAIPGDGVGKEVVAAAEKVLHTAAEVHGGLSFSFTA FPWSCDYYLEHGKMMPEDGIHTLTQFEAVFLGAVGNPKLVPDHISLWGLLLKIRRELE LSINMRPAKQMAGITSPLLHPNDFDFVVIRENSEGEYSEVGGRIHRGDDEIAIQNAVF TRKATERVMRFAFELAKKRRSHVTSATKSNGIYHAMPFWDEVFQQTAADYSGIETSSQ HIDALAAFFVTRPETFDVIVASNLFGDILTDISSSLMGSIGIAPSANINPSGKYPSMF EPVHGSAPDIAGQGLANPIGQIWTAKLMLDHFGEEELGAKILDVMEQVTADGIKTRDI GGQSTTAEVTDEICSRLRKL*" /label="ycsA CDS" gene 434397..435461 /gene="ycsA" /locus_tag="BSU_04000" /old_locus_tag="BSU04000" /label="ycsA gene" promotor_-35 434631..434639 /Source="Nicolas_upshift_promotors" /id="U309" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=1234 /SigmaFactorBS="atttgaagcagtttttttgggagctgtcGGAAATCCGaagct ggttcccgATCATATATCGTTATGGGGGctgctgctgaaaatccggagggagcttgag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 434653..434672 /Source="Nicolas_upshift_promotors" /id="U309" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=1234 /SigmaFactorBS="atttgaagcagtttttttgggagctgtcGGAAATCCGaagct ggttcccgATCATATATCGTTATGGGGGctgctgctgaaaatccggagggagcttgag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 434663 /Source="Nicolas_upshifts" /id="U309" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=1234 /SigmaFactorBS="atttgaagcagtttttttgggagctgtcGGAAATCCGaagct ggttcccgATCATATATCGTTATGGGGGctgctgctgaaaatccggagggagcttgag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 435455 /Source="Nicolas_upshifts" /id="D179" /incds=0 /nref=7 /ntot=41 /MaxReadThrough="4.24123" /MaxDrop="4.42639" /score="9.70532694" /energy="-11.6" /TU="U307,U308" /idTUdmin="U308" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" promotor_-35 435528..435535 /Source="Nicolas_upshift_promotors" /id="U310" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.567432567432567" /psig="0.996003996003996" /xcortree=2303 /SigmaFactorBS="atttccttacgaaaatttccacgaaagTCTAACCAagcagat ccaaaTGCTGTATAATAATTTGGAAttcttaggaaagcatcgggtgaaggaagttgaa t" /listShort="sipU, S133, ycsD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 435548..435567 /Source="Nicolas_upshift_promotors" /id="U310" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.567432567432567" /psig="0.996003996003996" /xcortree=2303 /SigmaFactorBS="atttccttacgaaaatttccacgaaagTCTAACCAagcagat ccaaaTGCTGTATAATAATTTGGAAttcttaggaaagcatcgggtgaaggaagttgaa t" /listShort="sipU, S133, ycsD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 435561 /Source="Nicolas_upshifts" /id="U310" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.567432567432567" /psig="0.996003996003996" /xcortree=2303 /SigmaFactorBS="atttccttacgaaaatttccacgaaagTCTAACCAagcagat ccaaaTGCTGTATAATAATTTGGAAttcttaggaaagcatcgggtgaaggaagttgaa t" /listShort="sipU, S133, ycsD" /GFF_Attribute="listLong" /label="upshifts" CDS 435596..436159 /gene="sipU" /locus_tag="BSU_04010" /old_locus_tag="BSU04010" /EC_number="3.4.21.89" /function="16.1: Circulate" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9325333, 10198007, 11856304, 14568161" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9325333, 10198007, 11856304, 14568161; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="type I signal peptidase" /protein_id="NP_388283.1" /db_xref="EnsemblGenomes-Gn:BSU04010" /db_xref="EnsemblGenomes-Tr:CAB12209" /db_xref="GOA:P42959" /db_xref="InterPro:IPR000223" /db_xref="InterPro:IPR015927" /db_xref="InterPro:IPR019756" /db_xref="InterPro:IPR019757" /db_xref="InterPro:IPR019758" /db_xref="InterPro:IPR036286" /db_xref="SubtiList:BG11223" /db_xref="UniProtKB/Swiss-Prot:P42959" /translation="MNAKTITLKKKRKIKTIVVLSIIMIAALIFTIRLVFYKPFLIEG SSMAPTLKDSERILVDKAVKWTGGFHRGDIIVIHDKKSGRSFVKRLIGLPGDSIKMKN DQLYINDKKVEEPYLKEYKQEVKESGVTLTGDFEVEVPSGKYFVMGDNRLNSLDSRNG MGMPSEDDIIGTESLVFYPFGEMRQAK*" /label="sipU CDS" gene 435596..436159 /gene="sipU" /locus_tag="BSU_04010" /old_locus_tag="BSU04010" /label="sipU gene" S_feature 436160..436884 /Source="Nicolas_S_feature" /locus_tag="new_454593_455317" /HighExp="G150, Oxctl, Lbexp, G135, Paraq, dia0, LBGexp, Mt0, G180, dia15" /AntisenseName="yczH" /AntisenseCor="0.134432865921808" /AntisenseRegPval="-1.6" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.996, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S133" CDS complement(436219..436827) /gene="yczH" /locus_tag="BSU_04020" /old_locus_tag="BSU04020" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_388284.2" /db_xref="EnsemblGenomes-Gn:BSU04020" /db_xref="EnsemblGenomes-Tr:CAB12210" /db_xref="GOA:O31482" /db_xref="InterPro:IPR002925" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12782" /db_xref="UniProtKB/Swiss-Prot:O31482" /translation="MFPKPLVILAHEIYGVNSHMKKMGRLIKMAGYDVLTPNLLGEDE VYTLKEEKTAYEQFTKHERLKTGETIIQNVIRQNAGRHIFVIGFSVGATIAWKCSSMP EVSGSVCYYGSRIRDSLHHMPACPVLLFFPNYEPSFDVALLIKKLREKQHTHLEIYQF DALHGFANPDSVYFNRALFFKTLSIIKNGAESRLRTVSSSFF*" /label="yczH CDS" gene complement(436219..436827) /gene="yczH" /locus_tag="BSU_04020" /old_locus_tag="BSU04020" /label="yczH gene" misc_feature complement(436845..436864) /Source="Nicolas_upshift_promotors" /id="U311" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.397602397602398" /psig="0.993006993006993" /xcortree=2931 /SigmaFactorBS="aagataatgagttcattttatatctcctttttttgaccatta tatctcagcctaaagtgaaacgATAGGATATAATGGAAAAAAcacaaaaggaggccgt t" /listShort="yczH" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-35 436861..436867 /Source="Nicolas_upshift_promotors" /id="U312" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.572427572427572" /psig="0.995004995004995" /xcortree=3001 /SigmaFactorBS="ataacggcctccttttgtgttttttccattatatcCTATCGT ttcactttaggcTGAGATATAATGGTCAAAAAaaggagatataaaatgaactcattat c" /listShort="ycsD" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(436868) /Source="Nicolas_upshifts" /id="U311" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.397602397602398" /psig="0.993006993006993" /xcortree=2931 /SigmaFactorBS="aagataatgagttcattttatatctcctttttttgaccatta tatctcagcctaaagtgaaacgATAGGATATAATGGAAAAAAcacaaaaggaggccgt t" /listShort="yczH" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 436880..436899 /Source="Nicolas_upshift_promotors" /id="U312" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.572427572427572" /psig="0.995004995004995" /xcortree=3001 /SigmaFactorBS="ataacggcctccttttgtgttttttccattatatcCTATCGT ttcactttaggcTGAGATATAATGGTCAAAAAaaggagatataaaatgaactcattat c" /listShort="ycsD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 436886 /Source="Nicolas_upshifts" /id="U312" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.572427572427572" /psig="0.995004995004995" /xcortree=3001 /SigmaFactorBS="ataacggcctccttttgtgttttttccattatatcCTATCGT ttcactttaggcTGAGATATAATGGTCAAAAAaaggagatataaaatgaactcattat c" /listShort="ycsD" /GFF_Attribute="listLong" /label="upshifts" CDS 436913..437305 /gene="ycsD" /locus_tag="BSU_04030" /old_locus_tag="BSU04030" /EC_number="4.2.1.-" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12682299, 16291680, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydroxyacyl-(acyl carrier protein) dehydratase" /protein_id="NP_388285.2" /db_xref="EnsemblGenomes-Gn:BSU04030" /db_xref="EnsemblGenomes-Tr:CAB12211" /db_xref="InterPro:IPR013114" /db_xref="InterPro:IPR029069" /db_xref="SubtiList:BG11225" /db_xref="UniProtKB/Swiss-Prot:P42961" /translation="MNSLSLPHRYPFLFIDGVTDSEPGKHAAAYKLISENDWFITDTQ TEMPFSLVIEALAQTAAFTGITDENSLGLLSSVKKAEKLGEAVPGDRLDLTFEVTRNR RGFVFGHAKASVGEQPVAEAEIGIYIEK*" /label="ycsD CDS" gene 436913..437305 /gene="ycsD" /locus_tag="BSU_04030" /old_locus_tag="BSU04030" /label="ycsD gene" downshifts 437282 /Source="Nicolas_upshifts" /id="D180" /incds=0 /nref=23 /ntot=189 /MaxReadThrough="1.8721" /MaxDrop="3.42324" /score="-5.4921522" /energy="-13.6" /TU="NA" /idTUdmin="U310" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(437338..437502) /gene="yczO" /locus_tag="BSU_04039" /old_locus_tag="BSU04039" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097679.1" /db_xref="EnsemblGenomes-Gn:BSU04039" /db_xref="EnsemblGenomes-Tr:CAX52550" /db_xref="UniProtKB/Swiss-Prot:C0H3V3" /translation="MTEKKQQNKPNENPEHNDLTDPIPNEELKENMNDEKHKRQQRDN SQSERDYDTK*" /label="yczO CDS" gene complement(437338..437502) /gene="yczO" /locus_tag="BSU_04039" /old_locus_tag="BSU04039" /label="yczO gene" downshifts complement(437358) /Source="Nicolas_upshifts" /id="D181" /incds=0 /nref=101 /ntot=193 /MaxReadThrough="1.44096" /MaxDrop="6.55741" /score="22.582242" /energy="-10.6" /TU="NA" /idTUdmin="U313" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(437512..437530) /Source="Nicolas_upshift_promotors" /id="U313" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=206 /SigmaFactorBS="ttctaatacattatacccagcgggacaaaaaagcgatttcct aTGTTTGAggagaatgaataagAGGAAAACAAACGGTGAGGtgatcaaacatgacaga a" /listShort="yczO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(437534) /Source="Nicolas_upshifts" /id="U313" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=206 /SigmaFactorBS="ttctaatacattatacccagcgggacaaaaaagcgatttcct aTGTTTGAggagaatgaataagAGGAAAACAAACGGTGAGGtgatcaaacatgacaga a" /listShort="yczO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(437545..437551) /Source="Nicolas_upshift_promotors" /id="U313" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=206 /SigmaFactorBS="ttctaatacattatacccagcgggacaaaaaagcgatttcct aTGTTTGAggagaatgaataagAGGAAAACAAACGGTGAGGtgatcaaacatgacaga a" /listShort="yczO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 437564..437571 /Source="Nicolas_upshift_promotors" /id="U314" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig=1 /xcortree=2352 /SigmaFactorBS="cctcttattcattctcctcaaacataggaaatcgctTTTTTG TCccgctgggtataaTGTATTAGAATAGAGAGAAGcacaacaaaaagataaagagagg t" /listShort="ycsE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 437585..437604 /Source="Nicolas_upshift_promotors" /id="U314" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig=1 /xcortree=2352 /SigmaFactorBS="cctcttattcattctcctcaaacataggaaatcgctTTTTTG TCccgctgggtataaTGTATTAGAATAGAGAGAAGcacaacaaaaagataaagagagg t" /listShort="ycsE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 437588 /Source="Nicolas_upshifts" /id="U314" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig=1 /xcortree=2352 /SigmaFactorBS="cctcttattcattctcctcaaacataggaaatcgctTTTTTG TCccgctgggtataaTGTATTAGAATAGAGAGAAGcacaacaaaaagataaagagagg t" /listShort="ycsE" /GFF_Attribute="listLong" /label="upshifts" CDS 437635..438384 /gene="ribZ" /locus_tag="BSU_04040" /old_locus_tag="BSU04040" /EC_number="3.1.3.-" /function="4.9: Riboflavin, FMN, and FAD" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 26316208, 27435445, 27784292; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-amino-6-ribitylamino-2,4(1H, 3H)-pyrimidinedione 5'-phosphate phosphatase / 5' nucleotidase" /protein_id="NP_388286.2" /db_xref="EnsemblGenomes-Gn:BSU04040" /db_xref="EnsemblGenomes-Tr:CAB12212" /db_xref="GOA:P42962" /db_xref="InterPro:IPR006379" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG11226" /db_xref="UniProtKB/Swiss-Prot:P42962" /translation="MSVQREDVDIKLIAIDMDGTLLNDEQLISDENRKAIREAEDKGV YVVISTGRTLMTCRELAESLKLSSFLITANGSEIWDSNFNLVERKLLHTDHIQMMWDL RNKHNTNFWASTVNKVWRGEFPENITDHEWLKFGFDIEDDDIRNEVLEELRKNKELEI TNSSPTNIEVNALGINKAAALAKVTEKLGFTMENVMAMGDSLNDIAMIKEAGLGVAMG NAQDIVKETADYITDTNIEDGVAKAIRHWVL*" /label="ribZ CDS" gene 437635..438384 /gene="ribZ" /locus_tag="BSU_04040" /old_locus_tag="BSU04040" /label="ribZ gene" downshifts 438361 /Source="Nicolas_upshifts" /id="D182" /incds=0 /nref=219 /ntot=253 /MaxReadThrough="3.23506" /MaxDrop="6.84998" /score="19.5535298" /energy="-11.7" /TU="NA" /idTUdmin="U314" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" downshifts complement(438437) /Source="Nicolas_upshifts" /id="D183" /incds=0 /nref=1 /ntot=7 /MaxReadThrough="0.52326" /MaxDrop="2.84763" /score="25.9755124" /energy="-11.7" /TU="NA" /idTUdmin="U313" /TUdmin="-1079" /isTUend="FALSE" /label="downshifts" promotor_-35 438467..438473 /Source="Nicolas_upshift_promotors" /id="U315" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.386613386613387" /psig="0.996003996003996" /xcortree=2194 /SigmaFactorBS="attctgggaccatggtaggttttctgacaaaagtATTTCACa aactgatatgatTCACTTATAATGAAATAAAGttcaaaaattcggaatagtcgttccg a" /listShort="S134, ycsF, ycsG, ycsI, kipI, kipA, kipR, lipC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 438487..438506 /Source="Nicolas_upshift_promotors" /id="U315" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.386613386613387" /psig="0.996003996003996" /xcortree=2194 /SigmaFactorBS="attctgggaccatggtaggttttctgacaaaagtATTTCACa aactgatatgatTCACTTATAATGAAATAAAGttcaaaaattcggaatagtcgttccg a" /listShort="S134, ycsF, ycsG, ycsI, kipI, kipA, kipR, lipC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 438493..438589 /Source="Nicolas_S_feature" /locus_tag="new_456926_457022" /HighExp="S1, Cold, S0, GM 5, BMM, MG 25, Lbtran, aero, GM 10, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S134" upshifts 438493 /Source="Nicolas_upshifts" /id="U315" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.386613386613387" /psig="0.996003996003996" /xcortree=2194 /SigmaFactorBS="attctgggaccatggtaggttttctgacaaaagtATTTCACa aactgatatgatTCACTTATAATGAAATAAAGttcaaaaattcggaatagtcgttccg a" /listShort="S134, ycsF, ycsG, ycsI, kipI, kipA, kipR, lipC" /GFF_Attribute="listLong" /label="upshifts" CDS 438590..439363 /gene="pxpA" /locus_tag="BSU_04050" /old_locus_tag="BSU04050" /EC_number="3.5.2.9" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9334321, 28830929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9334321, 28830929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oxoprolinase subunit A" /protein_id="NP_388287.3" /db_xref="EnsemblGenomes-Gn:BSU04050" /db_xref="EnsemblGenomes-Tr:CAB12213" /db_xref="GOA:P42963" /db_xref="InterPro:IPR005501" /db_xref="InterPro:IPR011330" /db_xref="SubtiList:BG11227" /db_xref="UniProtKB/Swiss-Prot:P42963" /translation="MFQIDLNCDLGESFGAYKIGLDQDILEYVTSANIACGFHAGDPS VMRKTVALAAERGVKMGAHPGLPDLLGFGRRNMAISPEEAYDLVVYQIGALSGFLKAE GLHMQHVKPHGALYNMAAVDQKLSDAIAKAVYKVDPGLILFGLAESELVKAGERIGLQ TANEVFADRTYQSDGTLTPRSQPDALIESDDAAVTQVIKMVKEGAVKSQQGHDVSLKA DTVCIHGDGAHALTFAQKIRKQLKAAGIEVTAISEQRST*" /label="pxpA CDS" gene 438590..439363 /gene="pxpA" /locus_tag="BSU_04050" /old_locus_tag="BSU04050" /label="pxpA gene" CDS 439378..440592 /gene="pxpG" /locus_tag="BSU_04060" /old_locus_tag="BSU04060" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 9334321, 15849754, 16850406, 28830929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-oxoproline transporter" /protein_id="NP_388288.3" /db_xref="EnsemblGenomes-Gn:BSU04060" /db_xref="EnsemblGenomes-Tr:CAB12214" /db_xref="GOA:P42964" /db_xref="InterPro:IPR001046" /db_xref="SubtiList:BG11228" /db_xref="UniProtKB/Swiss-Prot:P42964" /translation="MEQQKKTAGKKAGSWSLLMGAAFLMATSAIGPGFLTQTATFTNT LAASFGFVILISIILDIFAQTNVWRIIAVSGKRGQEIANMVLPGLGYFIAILVVLGGL AFNIGNIGGAGLGLQVLFGITPETGALISAVIAILIFVIKEAGKAMDRFTQIAGFVMI ILTVYVAATTAPPVGQAVANTFVPEHISIFAIVTLVGGTVGGYITFAGGHRLLDAGIK GKESIPQVTKSSVVGILITSVMRIALFLAVLGVVSKGLHIDESNPAASVFKLAAGNVG YKIFGLIMWSAAITSVIGAAYTSVSFFKTFSPKIEKNSRGIIIGFIVVSTLAFVTIGQ PAKILVLVGSLNGLILPIALGTLLVAAYKKNIVGDYKHPLWLTSTGALVVIVMAVMGI YTLCTQLPQLWS*" /label="pxpG CDS" gene 439378..440592 /gene="pxpG" /locus_tag="BSU_04060" /old_locus_tag="BSU04060" /label="pxpG gene" CDS 440616..441389 /gene="pxpI" /locus_tag="BSU_04070" /old_locus_tag="BSU04070" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8186229, 9334321, 28830929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative D-5-oxoproline epimerase" /protein_id="NP_388289.3" /db_xref="EnsemblGenomes-Gn:BSU04070" /db_xref="EnsemblGenomes-Tr:CAB12215" /db_xref="GOA:P42966" /db_xref="InterPro:IPR009906" /db_xref="InterPro:IPR016938" /db_xref="SubtiList:BG11230" /db_xref="UniProtKB/Swiss-Prot:P42966" /translation="MAPKDVRALIREGKINGPTAGMSGGYAQANLVVLKKDLAFDFLL FCQRNQKPCPVLDVTEAGSPVPSLAAPDADIRTDFPKYRIYRHGILTEEVSDITPYWE DDFVGFLIGCSFSFEQALINNGIAVRHIDEGTNVSMYKTNIDCVPAGAFHGQMVVSMR PVPERLAVRAAQVTSRFPAVHGGPIHIGNPGAIGIRDLGKPDFGDAVSIRDGEVPVFW ACGVTPQAVAMNVKPEMVITHAPGHMLITDIRDESLAVL*" /label="pxpI CDS" gene 440616..441389 /gene="pxpI" /locus_tag="BSU_04070" /old_locus_tag="BSU04070" /label="pxpI gene" CDS 441434..442156 /gene="pxpB" /locus_tag="BSU_04080" /old_locus_tag="BSU04080" /EC_number="3.5.2.9" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9334321, 18823995, 19040634, 20524093, 21050859, 21245531, 22277658, 28830929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9334321, 18823995, 19040634, 20524093, 21050859, 21245531, 22277658, 28830929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-5-oxoprolinase (ATP-dependent) subunit B" /protein_id="NP_388290.2" /db_xref="EnsemblGenomes-Gn:BSU04080" /db_xref="EnsemblGenomes-Tr:CAB12216" /db_xref="GOA:P60495" /db_xref="InterPro:IPR003833" /db_xref="InterPro:IPR010016" /db_xref="InterPro:IPR024946" /db_xref="InterPro:IPR029000" /db_xref="PDB:2KWA" /db_xref="PDB:2ZP2" /db_xref="SubtiList:BG11231" /db_xref="UniProtKB/Swiss-Prot:P60495" /translation="MTVRYQIEQLGDSAMMIRFGEEINEQVNGIVHAAAAYIEEQPFP GFIECIPAFTSLTVFYDMYEVYKHLPQGISSPFESVKRDVEERLAEIAEDYEVNRRIV EIPVCYGGEFGPDLEEVAKINQLSPEEVIDIHTNGEYVVYMLGFAPGFPFLGGMSKRI AAPRKSSPRPSIPAGSVGIAGLQTGVYPISTPGGWQLIGKTPLALFRPQENPPTLLRA GDIVKFVRISEKDYHAYKEESN*" /label="pxpB CDS" gene 441434..442156 /gene="pxpB" /locus_tag="BSU_04080" /old_locus_tag="BSU04080" /label="pxpB gene" CDS 442159..443166 /gene="pxpC" /locus_tag="BSU_04090" /old_locus_tag="BSU04090" /EC_number="3.5.2.9" /function="16.6: Maintain" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9334321, 18823995, 19040634, 20524093, 21050859, 21245531, 22277658, 28830929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9334321, 18823995, 19040634, 20524093, 21050859, 21245531, 22277658, 28830929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-5-oxoprolinase (ATP-dependent) subunit C" /protein_id="YP_054571.2" /db_xref="EnsemblGenomes-Gn:BSU04090" /db_xref="EnsemblGenomes-Tr:CAE01447" /db_xref="GOA:Q7WY77" /db_xref="InterPro:IPR003778" /db_xref="InterPro:IPR029000" /db_xref="SubtiList:BG14193" /db_xref="UniProtKB/Swiss-Prot:Q7WY77" /translation="MKVLKPGLLTTVQDIGRTGYQKYGVLASGAMDTVSLRIANLLIG NGENEAGLEITMMGPGPSFHFSKQTLIAVTGADFTLRINDEEAPLWKPVLIKENSTVS FGPCKLGSRAYLAAAGGIEVPAVMESKSTYVRGSIGGLHGRALQKEDELNIGEMSALS QTILSRLSSQLGKQGFAAPKWSVSRGRFLPLKKNPVIRVLEGKQFAFFTEESKTRFYE EAFRVTPQSDRMGYRLKGEPLELKAPLEMVSEAVSFGTVQVPPDGNPIILLADRQTTG GYPRIAHIISADLPIVSQIMPGEHVQFEPVSLQEAEALAVEREQHIKELKTRMKMEWL T*" /label="pxpC CDS" gene 442159..443166 /gene="pxpC" /locus_tag="BSU_04090" /old_locus_tag="BSU04090" /label="pxpC gene" downshifts 442652 /Source="Nicolas_upshifts" /id="D184" /incds=1 /nref=6 /ntot=27 /MaxReadThrough="5.04721" /MaxDrop="4.5277" /score="-7.2426149" /energy="-12.4" /TU="U315" /idTUdmin="U315" /TUdmin="-1975" /isTUend="FALSE" /label="downshifts" promotor_no_box 442746..442846 /Source="Nicolas_upshift_promotors" /id="U316" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.645354645354645" /psig="0.020979020979021" /xcortree=1726 /SigmaFactorBS="cattcgggtgctggaaggaaagcaatttgcctttttcacaga agaatcaaaaacgcgtttttatgaagaagcatttcgtgtcacgccgcagtccgaccgt a" /listShort="kipR, lipC" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 442806 /Source="Nicolas_upshifts" /id="U316" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.645354645354645" /psig="0.020979020979021" /xcortree=1726 /SigmaFactorBS="cattcgggtgctggaaggaaagcaatttgcctttttcacaga agaatcaaaaacgcgtttttatgaagaagcatttcgtgtcacgccgcagtccgaccgt a" /listShort="kipR, lipC" /GFF_Attribute="listLong" /label="upshifts" CDS 443182..443934 /gene="pxpR" /locus_tag="BSU_04100" /old_locus_tag="BSU04100" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9334321; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of the pxp operon (IclR family)" /protein_id="NP_388291.2" /db_xref="EnsemblGenomes-Gn:BSU04100" /db_xref="EnsemblGenomes-Tr:CAB12217" /db_xref="GOA:P42968" /db_xref="InterPro:IPR005471" /db_xref="InterPro:IPR014757" /db_xref="InterPro:IPR029016" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11214" /db_xref="UniProtKB/Swiss-Prot:P42968" /translation="MQNKNKTVVKSMALLNLFLHKPSLTLSELVSLTGMPKTSVHRMV SSLEEMGFLSRDASGAYSLGLVFLEFGQLVADRLDIRKIAKPVMEELCREVDEAVQLI MRDGNEAIYVEKIEGTQTVRLYTAIGRRSPLYAGACARSILSFLPREEIEAYIKQTEL ISIGSGTITDPEKLLQEIDASVQNGYTVSYSELENYTAAIGAPIFNHERQVAAGISIA GFEARFTEDRLPYLTEKVKDAALQISRKIGYT*" /label="pxpR CDS" gene 443182..443934 /gene="pxpR" /locus_tag="BSU_04100" /old_locus_tag="BSU04100" /label="pxpR gene" promotor_-35 443932..443941 /Source="Nicolas_upshift_promotors" /id="U317" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1275 /SigmaFactorBS="cagatttcaagaaaaataggatatacaTAAGTAGCCAatctt ttctctgcTGCGTACATTAACGTATCGAcgttcaagagtggaggaaagaacatggtgc t" /listShort="lipC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 443955..443974 /Source="Nicolas_upshift_promotors" /id="U317" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1275 /SigmaFactorBS="cagatttcaagaaaaataggatatacaTAAGTAGCCAatctt ttctctgcTGCGTACATTAACGTATCGAcgttcaagagtggaggaaagaacatggtgc t" /listShort="lipC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 443965 /Source="Nicolas_upshifts" /id="U317" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1275 /SigmaFactorBS="cagatttcaagaaaaataggatatacaTAAGTAGCCAatctt ttctctgcTGCGTACATTAACGTATCGAcgttcaagagtggaggaaagaacatggtgc t" /listShort="lipC" /GFF_Attribute="listLong" /label="upshifts" CDS 443998..444639 /gene="lipC" /locus_tag="BSU_04110" /old_locus_tag="BSU04110" /EC_number="3.1.1.-" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9334321, 17220230, 20057119" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9334321, 17220230, 20057119; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore coat phospholipase B" /protein_id="NP_388292.1" /db_xref="EnsemblGenomes-Gn:BSU04110" /db_xref="EnsemblGenomes-Tr:CAB12218" /db_xref="GOA:P42969" /db_xref="InterPro:IPR013830" /db_xref="InterPro:IPR036514" /db_xref="SubtiList:BG11232" /db_xref="UniProtKB/Swiss-Prot:P42969" /translation="MVLRYTALGDSLTTGRGSGLFSPGFVQRFGDMMEADLKTRTAIN IFARSGLNTEEILGLLSYPYVQKCIRDADMITITGCGNDLIDSVLAYQTSKDETIFSR VSAHCHENFEKMIAKVAEIKGENPSPYAIRVFNLYNPFPEIDIAGKWITSFNSHLETL ASAPHVKIADAYSIFKGKEQEYLSFDGVHPNSKGYQAMAEAVHKLGYKELSVS*" /label="lipC CDS" gene 443998..444639 /gene="lipC" /locus_tag="BSU_04110" /old_locus_tag="BSU04110" /label="lipC gene" downshifts 444625 /Source="Nicolas_upshifts" /id="D185" /incds=0 /nref=106 /ntot=223 /MaxReadThrough="0.550230000000001" /MaxDrop="6.63515" /score="26.7371783" /energy="-11.8" /TU="NA" /idTUdmin="U315" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" S_feature complement(444637..445062) /Source="Nicolas_S_feature" /locus_tag="new_463070_463495_c" /HighExp="S1, Sw, BC, S2, Lbtran, M0t90, LPhT, BI, M40t45, C90" /AntisenseName="yczI" /AntisenseCor="-0.57558682544748696" /AntisenseRegPval="-24.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.965" /TUlongSig="NA" /TUlongPSig="NA" /label="S135" downshifts complement(444682) /Source="Nicolas_upshifts" /id="D186" /incds=0 /nref=171 /ntot=252 /MaxReadThrough="1.91715" /MaxDrop="5.13764" /score="6.4765859" /energy="-11.8" /TU="NA" /idTUdmin="U319" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 444715..444721 /Source="Nicolas_upshift_promotors" /id="U318" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.361638361638362" /psig="0.998001998001998" /xcortree=2779 /SigmaFactorBS="gatcgaaatattaaaagaaacttaaaattctctgtcttcTGT TCTAcagacaaacaaagTGCGCTAGAATAATGGAGGGcgtaggcaaatatagccataa c" /listShort="yczI, S136, pbpC, S137, ycsN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 444735..444754 /Source="Nicolas_upshift_promotors" /id="U318" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.361638361638362" /psig="0.998001998001998" /xcortree=2779 /SigmaFactorBS="gatcgaaatattaaaagaaacttaaaattctctgtcttcTGT TCTAcagacaaacaaagTGCGCTAGAATAATGGAGGGcgtaggcaaatatagccataa c" /listShort="yczI, S136, pbpC, S137, ycsN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 444736 /Source="Nicolas_upshifts" /id="U318" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.361638361638362" /psig="0.998001998001998" /xcortree=2779 /SigmaFactorBS="gatcgaaatattaaaagaaacttaaaattctctgtcttcTGT TCTAcagacaaacaaagTGCGCTAGAATAATGGAGGGcgtaggcaaatatagccataa c" /listShort="yczI, S136, pbpC, S137, ycsN" /GFF_Attribute="listLong" /label="upshifts" CDS 444812..445057 /gene="yczI" /locus_tag="BSU_04120" /old_locus_tag="BSU04120" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388293.1" /db_xref="EnsemblGenomes-Gn:BSU04120" /db_xref="EnsemblGenomes-Tr:CAB12219" /db_xref="GOA:P42970" /db_xref="InterPro:IPR025018" /db_xref="SubtiList:BG12783" /db_xref="UniProtKB/Swiss-Prot:P42970" /translation="MFRIFKMSFAVIIIILALIAFNYTEHTSVIQSVMLVFLGAVMFM QGLEERKKENDGSGAFNIYTAVFVWSVSLIGFTLHII*" /label="yczI CDS" gene 444812..445057 /gene="yczI" /locus_tag="BSU_04120" /old_locus_tag="BSU04120" /label="yczI gene" S_feature 445058..445468 /Source="Nicolas_S_feature" /locus_tag="new_463491_463901" /HighExp="T5.0H, T2.30H, T3.30H, T2.0H, T3.0H, T4.0H, T1.30H, M9-stat, T-4.40H, T-3.40H" /AntisenseName="yczJ" /AntisenseCor="-0.20847541933848601" /AntisenseRegPval="-3.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S136" CDS complement(445063..445350) /gene="yczJ" /locus_tag="BSU_04130" /old_locus_tag="BSU04130" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388294.1" /db_xref="EnsemblGenomes-Gn:BSU04130" /db_xref="EnsemblGenomes-Tr:CAB12220" /db_xref="InterPro:IPR007138" /db_xref="InterPro:IPR011008" /db_xref="SubtiList:BG12784" /db_xref="UniProtKB/Swiss-Prot:O31484" /translation="MVREAAMLHIKEGLEQEFEDAFRQAAPIISGMKGYITHSLSKCM EETHKYLLLVEWETLEDHTEGFRGSSEYQEWKALLHRFYTPFPTVEHFQDV*" /label="yczJ CDS" gene complement(445063..445350) /gene="yczJ" /locus_tag="BSU_04130" /old_locus_tag="BSU04130" /label="yczJ gene" misc_feature complement(445371..445390) /Source="Nicolas_upshift_promotors" /id="U319" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.542457542457542" /psig="0.965034965034965" /xcortree=1595 /SigmaFactorBS="aagatttttttgaaaatgaaggaaaagttcaccgattttgca gaaatctcctatcgtTTGCTGTAGACTATTTGAAAagacagaaagaagggatagcatg g" /listShort="yczJ, S135" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(445387) /Source="Nicolas_upshifts" /id="U319" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.542457542457542" /psig="0.965034965034965" /xcortree=1595 /SigmaFactorBS="aagatttttttgaaaatgaaggaaaagttcaccgattttgca gaaatctcctatcgtTTGCTGTAGACTATTTGAAAagacagaaagaagggatagcatg g" /listShort="yczJ, S135" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 445444..445448 /Source="Nicolas_upshift_promotors" /id="U320" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.855144855144855" /psig="0.946053946053946" /xcortree=2681 /SigmaFactorBS="aaatcggtgaacttttccttcattttcaaaaaaaTCTTGcac gcaccaattcaatTAAGAGAAAATAACAAGTGGaaggcaggggaaagtcatgttaaaa a" /listShort="pbpC, S137, ycsN, S138, mtlR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 445465..445484 /Source="Nicolas_upshift_promotors" /id="U320" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.855144855144855" /psig="0.946053946053946" /xcortree=2681 /SigmaFactorBS="aaatcggtgaacttttccttcattttcaaaaaaaTCTTGcac gcaccaattcaatTAAGAGAAAATAACAAGTGGaaggcaggggaaagtcatgttaaaa a" /listShort="pbpC, S137, ycsN, S138, mtlR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 445470 /Source="Nicolas_upshifts" /id="U320" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.855144855144855" /psig="0.946053946053946" /xcortree=2681 /SigmaFactorBS="aaatcggtgaacttttccttcattttcaaaaaaaTCTTGcac gcaccaattcaatTAAGAGAAAATAACAAGTGGaaggcaggggaaagtcatgttaaaa a" /listShort="pbpC, S137, ycsN, S138, mtlR" /GFF_Attribute="listLong" /label="upshifts" CDS 445501..447507 /gene="pbpC" /locus_tag="BSU_04140" /old_locus_tag="BSU04140" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8830698, 10648534" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8830698, 10648534; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="penicillin-binding lipoprotein 3; transpeptidase" /protein_id="NP_388295.1" /db_xref="EnsemblGenomes-Gn:BSU04140" /db_xref="EnsemblGenomes-Tr:CAB12221" /db_xref="GOA:P42971" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR005311" /db_xref="InterPro:IPR007887" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR032710" /db_xref="InterPro:IPR036138" /db_xref="SubtiList:BG11234" /db_xref="UniProtKB/Swiss-Prot:P42971" /translation="MLKKCILLVFLCVGLIGLIGCSKTDSPEDRMEAFVKQWNDQQFD DMYQSLTKDVKKEISKKDFVNRYKAIYEQAGVKNLKVTAGEVDKDDQDNKTMKHIPYK VSMNTNAGKVSFKNTAVLKLEKTDDEESWNIDWDPSFIFKQLADDKTVQIMSIEPKRG QIYDKNGKGLAVNTDVPEIGIVPGELGDKKEKVIKELAKKLDLTEDDIKKKLDQGWVK DDSFVPLKKVKPDQEKLVSEATSLQGVTRTNVSSRYYPYGEKTAHLTGYVRAITAEEL KKKKEGTYSDTSNIGIAGLENVYEDKLRGTTGWKIYVPQTGEVIAEKKAKDGEDLHLT IDIKTQMKLYDELKDDSGAAVALQPKTGETLALVSAPSYDPNGFIFGWSDKEWKKLNK DKNNPFSAKFNKTYAPGSTIKPIAAAIGIKNGTLKADEKKTIKGKEWQKDSSWGGYSV TRVSERLQQVDLENALITSDNIYFAQNALDMGADTFTKGLKTFGFSEDVPYEFPIQKS SIANDKLDSDILLADTGYGQGQMQMSPLHLATAYTPFVDNGDLVKPTLIKKDSQTADV WHKQVVTKEGAADITKGLKGVVEDERGSAYQPVVKGITVAGKTGTAELKTSKDDKDGT ENGWFVGYDYENKDLLVAMMIQNVQDRGGSHYVVEKAKKQFQSN*" /label="pbpC CDS" gene 445501..447507 /gene="pbpC" /locus_tag="BSU_04140" /old_locus_tag="BSU04140" /label="pbpC gene" S_feature 447508..447608 /Source="Nicolas_S_feature" /locus_tag="new_465941_466041" /HighExp="LBGstat, T5.0H, M0t45, T3.30H, S0, LBGtran, Oxctl, T4.0H, C30, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.946, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S137" CDS 447609..448511 /gene="ycsN" /locus_tag="BSU_04150" /old_locus_tag="BSU04150" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388296.1" /db_xref="EnsemblGenomes-Gn:BSU04150" /db_xref="EnsemblGenomes-Tr:CAB12222" /db_xref="GOA:P42972" /db_xref="InterPro:IPR020471" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="SubtiList:BG11235" /db_xref="UniProtKB/Swiss-Prot:P42972" /translation="MQRIQLAEDLQFSRVIHGLWRLNEWNYSDAELLSLIEWCIDHGI TTFDHADIYGGYTCEKLFGNALALSPGLRENIELVTKCGIVLESPERPAHRSHHYNTS KSHILASVEQSLMNLRTDYIDMLLIHRPDPLMDPEGVAEAFQALKCSGKVRYFGVSNF KDHQYRMLESYLPEKLVTNQIELSAYELENMLDGTLNLCQEKRIPPMAWSPLAGGKVF TENTDKDRRVRTALESVQGEIGAASLDEVMYAWLYTHPAGIMPIVGSGKRERISAAIN ALSYKLDQDQWFRIFTAVQGYDIP*" /label="ycsN CDS" gene 447609..448511 /gene="ycsN" /locus_tag="BSU_04150" /old_locus_tag="BSU04150" /label="ycsN gene" downshifts 448491 /Source="Nicolas_upshifts" /id="D187" /incds=0 /nref=48 /ntot=206 /MaxReadThrough="3.20352" /MaxDrop="4.57855" /score="1.36962171" /energy="-10.6" /TU="U320" /idTUdmin="U318" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" promotor_-35 448584..448591 /Source="Nicolas_upshift_promotors" /id="U321" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.779220779220779" /psig="0.995004995004995" /xcortree=1547 /SigmaFactorBS="gtcacaccgcttagtgccaaattaccatttataagTGATTGA TtctttcttgaaagCGTTTTATATTAAAAGGAAAcctctctatatcctctactgcatc t" /listShort="S138, mtlR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 448605..448624 /Source="Nicolas_upshift_promotors" /id="U321" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.779220779220779" /psig="0.995004995004995" /xcortree=1547 /SigmaFactorBS="gtcacaccgcttagtgccaaattaccatttataagTGATTGA TtctttcttgaaagCGTTTTATATTAAAAGGAAAcctctctatatcctctactgcatc t" /listShort="S138, mtlR" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 448609..448696 /Source="Nicolas_S_feature" /locus_tag="new_467042_467129" /HighExp="S0, Gly, BC, Lbstat, S2, M9-stat, G135, dia5, T0.30H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.995, 0.946" /TUlongSig="NA" /TUlongPSig="NA" /label="S138" upshifts 448609 /Source="Nicolas_upshifts" /id="U321" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.779220779220779" /psig="0.995004995004995" /xcortree=1547 /SigmaFactorBS="gtcacaccgcttagtgccaaattaccatttataagTGATTGA TtctttcttgaaagCGTTTTATATTAAAAGGAAAcctctctatatcctctactgcatc t" /listShort="S138, mtlR" /GFF_Attribute="listLong" /label="upshifts" CDS 448697..450781 /gene="mtlR" /locus_tag="BSU_04160" /old_locus_tag="BSU04160" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12897001, 23279188, 24196428, 26159071" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12897001, 23279188, 24196428, 26159071; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator, PTS-dependent activator" /protein_id="NP_388297.1" /db_xref="EnsemblGenomes-Gn:BSU04160" /db_xref="EnsemblGenomes-Tr:CAB12223" /db_xref="GOA:P96574" /db_xref="InterPro:IPR002178" /db_xref="InterPro:IPR003501" /db_xref="InterPro:IPR007737" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR013011" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR016152" /db_xref="InterPro:IPR036095" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="InterPro:IPR036634" /db_xref="SubtiList:BG12049" /db_xref="UniProtKB/Swiss-Prot:P96574" /translation="MYMTAREQKLLKHLLLQNRYITVTELAELMQVSTRTIHRELKSI KPLMETVGLTLDKQPGKGLKAVGSPEGKQKLLTDLSYEQHEYSADERKLLILCSLLES QEPVKLYTLAHDLQVTNATVSYDLDELEKWISPFGLTLIRKRGFGIQLIGPENAKRKI VGNLIVNRLDIQMFLEAVELNIKGKTDSSEKMFGVVSKGELLKMERILFQLKEKIAFS LSDSSYIALVVHLTYAIERIKLGETITMEQNELEELMNAKEYSSALEIAGELERAFGV TIPEAEVGYITIHLRSANRKYKTEYKAQEIELETALQTKRLIAFISDKIRMDLTKNYS LYEGLIAHLEPAVSRIKENIEIYNPMKEQIKRDYFLLYMAIEEGVEKYFPGMSFSDDE IAFIVLHFGSALEIKKEEAKVKALVVCSSGIGSSKMLASRLKKELPEIESFDMSSLIE LKGKDVQAYDMIVSTVPIPYENIDYIMVSPLLNEEDANQVKQYIKRKIPLILNKKRSS KEEAQQADVPDMLEAAESIGRYMEVIQDVLRHFTLAQLKTNPDHSMLLLELFQQLKKD GLIRDPEKAAVCLAEREKQGGLGIPGTNMALYHLKNDEIVLPFFKMFDLSTPYEVDGM DGNTLRMTRILVMMAPGSLSAEGSEILSAISSAIIESGESMAGFQEEGGQELYQRLNR IFFTWMKEKNIL*" /label="mtlR CDS" gene 448697..450781 /gene="mtlR" /locus_tag="BSU_04160" /old_locus_tag="BSU04160" /label="mtlR gene" downshifts 450768 /Source="Nicolas_upshifts" /id="D188" /incds=0 /nref=107 /ntot=220 /MaxReadThrough="1.91059" /MaxDrop="5.63565" /score="9.4904968" /energy="-12.4" /TU="NA" /idTUdmin="U321" /TUdmin="-19" /isTUend="TRUE" /label="downshifts" promotor_-35 450810..450816 /Source="Nicolas_upshift_promotors" /id="U322" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=739 /SigmaFactorBS="acctgcatggcacacgtcaaaaatttggCGTGTGTttttctg tggatgGGGAACAAAATAAGAAAATgtgggactattttatcattcagtattggaataa t" /listShort="S139, ydaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 450830..450848 /Source="Nicolas_upshift_promotors" /id="U322" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=739 /SigmaFactorBS="acctgcatggcacacgtcaaaaatttggCGTGTGTttttctg tggatgGGGAACAAAATAAGAAAATgtgggactattttatcattcagtattggaataa t" /listShort="S139, ydaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 450842 /Source="Nicolas_upshifts" /id="U322" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=739 /SigmaFactorBS="acctgcatggcacacgtcaaaaatttggCGTGTGTttttctg tggatgGGGAACAAAATAAGAAAATgtgggactattttatcattcagtattggaataa t" /listShort="S139, ydaB" /GFF_Attribute="listLong" /label="upshifts" S_feature 450853..450934 /Source="Nicolas_S_feature" /locus_tag="new_469286_469367" /HighExp="Etha, S5, S6, ferm, S8, nit, S7, BT, Salt, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S139" promotor_-35 450896..450903 /Source="Nicolas_upshift_promotors" /id="U323" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.69030969030969" /psig="0.992007992007992" /xcortree=1439 /SigmaFactorBS="gaataattccaaaatgaaatAGTTTTACaagttatctttttT GGGTTAAAATGGGTGAGGTaaggaagaaaatctaacaaattattgaagattcaagaga a" /listShort="ydaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 450917..450936 /Source="Nicolas_upshift_promotors" /id="U323" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.69030969030969" /psig="0.992007992007992" /xcortree=1439 /SigmaFactorBS="gaataattccaaaatgaaatAGTTTTACaagttatctttttT GGGTTAAAATGGGTGAGGTaaggaagaaaatctaacaaattattgaagattcaagaga a" /listShort="ydaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 450936 /Source="Nicolas_upshifts" /id="U323" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.69030969030969" /psig="0.992007992007992" /xcortree=1439 /SigmaFactorBS="gaataattccaaaatgaaatAGTTTTACaagttatctttttT GGGTTAAAATGGGTGAGGTaaggaagaaaatctaacaaattattgaagattcaagaga a" /listShort="ydaB" /GFF_Attribute="listLong" /label="upshifts" CDS 450993..452504 /gene="ydaB" /locus_tag="BSU_04170" /old_locus_tag="BSU04170" /EC_number="6.2.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyl-CoA ligase" /protein_id="NP_388298.2" /db_xref="EnsemblGenomes-Gn:BSU04170" /db_xref="EnsemblGenomes-Tr:CAB12224" /db_xref="GOA:P96575" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="SubtiList:BG12050" /db_xref="UniProtKB/Swiss-Prot:P96575" /translation="METLQHLILHDMPNSEEIEAVKSGDHTLTYKGYRKRINQLANAM LQKGIQKGDRVALLCKNGHPASTVMFAALEIGAVVVPVSWQLKPYEMTGILKASEPKA MFYGAEFKEILDEVLPELSSLCVTMETGTAYETSAEFEALFAGPDHLPETEMVSPDDT ALLMFTSGTTGNPKRCMITHGGIYRYVKKSNSSIARMKGLRFLACHPIYHTSALICIM LGTFAETTFVFTKDQDPVHMLKVIEEEKIQTVMALPVFYTYLLEAWEKHQTDLSSLVI LMTGGTKVPSSLISRYLDIGIPLAHGYGSTEAWGISTWTPDMGMDKAASAGKPVAGVK VKVEDPLTGEELPQGEIGEIVVHTPFLFKGYEDNPEATAKVLQNGWFRTGDSGYVDED GFIFITGRYKDVIIYGGDNVYPDQVEEVIQQIPGILETAVVGIPDPLYGEKPKAFIVK NGGQRITEEDVIAFCKERLSAYKIPEVEFVNELPKNNLGKVKKDVLRNQAVHS*" /label="ydaB CDS" gene 450993..452504 /gene="ydaB" /locus_tag="BSU_04170" /old_locus_tag="BSU04170" /label="ydaB gene" downshifts 452488 /Source="Nicolas_upshifts" /id="D189" /incds=0 /nref=3 /ntot=55 /MaxReadThrough="0.57376" /MaxDrop="3.70168" /score="9.4904968" /energy="-12.4" /TU="NA" /idTUdmin="U323" /TUdmin=73 /isTUend="FALSE" /label="downshifts" CDS complement(452524..453069) /gene="ydaC" /locus_tag="BSU_04180" /old_locus_tag="BSU04180" /EC_number="2.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative methyltransferase" /protein_id="NP_388299.1" /db_xref="EnsemblGenomes-Gn:BSU04180" /db_xref="EnsemblGenomes-Tr:CAB12225" /db_xref="GOA:P96576" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG12051" /db_xref="UniProtKB/Swiss-Prot:P96576" /translation="MIAGYIMAAENQTLNQWTINQLGITRGDSILEVGFGPGYCMQQM LKREKDVHLHGIDVSEAMLKLAARRVKPKGVRLIQGSIETFPLPASFYDKVISVNNYT IWNDQTKGIKQIYRALKPGGKAAITMQPREADASPEKTKSFGRQMIADFKAAGFEDID IQFKNIKPELSVCATAKKPAT*" /label="ydaC CDS" gene complement(452524..453069) /gene="ydaC" /locus_tag="BSU_04180" /old_locus_tag="BSU04180" /label="ydaC gene" downshifts complement(452557) /Source="Nicolas_upshifts" /id="D190" /incds=0 /nref=3 /ntot=11 /MaxReadThrough="1.44039" /MaxDrop="3.73662" /score="-9.35066962" /energy="-11.5" /TU="NA" /idTUdmin="U324" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(453136..453154) /Source="Nicolas_upshift_promotors" /id="U324" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=211 /SigmaFactorBS="tggcttggcaccttcgcattgctttatcagaaaaaTGTTTCA catggaacgctgagAGGAAATTAACTCAAAAAGggggttggttgctgaatgattaaca t" /listShort="ydaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(453150) /Source="Nicolas_upshifts" /id="U324" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=211 /SigmaFactorBS="tggcttggcaccttcgcattgctttatcagaaaaaTGTTTCA catggaacgctgagAGGAAATTAACTCAAAAAGggggttggttgctgaatgattaaca t" /listShort="ydaC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(453169..453175) /Source="Nicolas_upshift_promotors" /id="U324" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=211 /SigmaFactorBS="tggcttggcaccttcgcattgctttatcagaaaaaTGTTTCA catggaacgctgagAGGAAATTAACTCAAAAAGggggttggttgctgaatgattaaca t" /listShort="ydaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 453211..453217 /Source="Nicolas_upshift_promotors" /id="U325" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=191 /SigmaFactorBS="tgaaacatttttctgataaagcaatgcgaaggtgccaagcca TGTTTATccaaagagtgtgtgAGGTACACAACAAATAGACatgaaaacaaaggaggag a" /listShort="ydaD, ydaE, ydaF" /listLong="ydaG, S140" /label="promotor_-35" upshifts 453229 /Source="Nicolas_upshifts" /id="U325" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=191 /SigmaFactorBS="tgaaacatttttctgataaagcaatgcgaaggtgccaagcca TGTTTATccaaagagtgtgtgAGGTACACAACAAATAGACatgaaaacaaaggaggag a" /listShort="ydaD, ydaE, ydaF" /listLong="ydaG, S140" /label="upshifts" promotor_-10 453232..453250 /Source="Nicolas_upshift_promotors" /id="U325" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=191 /SigmaFactorBS="tgaaacatttttctgataaagcaatgcgaaggtgccaagcca TGTTTATccaaagagtgtgtgAGGTACACAACAAATAGACatgaaaacaaaggaggag a" /listShort="ydaD, ydaE, ydaF" /listLong="ydaG, S140" /label="promotor_-10" CDS 453276..454136 /gene="ydaD" /locus_tag="BSU_04190" /old_locus_tag="BSU04190" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10220166, 11948145, 15805528, 21520290, 28197687; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dehydrogenase" /protein_id="NP_388300.1" /db_xref="EnsemblGenomes-Gn:BSU04190" /db_xref="EnsemblGenomes-Tr:CAB12226" /db_xref="GOA:P80873" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12052" /db_xref="UniProtKB/Swiss-Prot:P80873" /translation="MANYPKELPAQTQSRQPGIESEMNPSPVYEYEDYKGADKLKGKV ALITGGDSGIGRAVSVAYAKEGADIAIVYKDEHEDAEETKKRVEQEGVKCLLIAGDVG EEEFCNEAVEKTVKELGGLDILVNNAGEQHPKESIKDITSEQLHRTFKTNFYSQFYLT KKAIDYLKPGSAIINTTSINPYVGNPTLIDYTATKGAINAFTRTMAQALVKDGIRVNA VAPGPIWTPLIPATFPEETVAQFGQDTPMGRPGQPVEHVGCYVLLASDESSYMTGQTL HVNGGNFVTT*" /label="ydaD CDS" gene 453276..454136 /gene="ydaD" /locus_tag="BSU_04190" /old_locus_tag="BSU04190" /label="ydaD gene" CDS 454152..454655 /gene="lyxE" /locus_tag="BSU_04200" /old_locus_tag="BSU04200" /EC_number="5.3.1.15" /experiment="publication(s) with functional evidences, PMID:10220166, 15805528, 21421786, 21520290" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10220166, 15805528, 21421786, 21520290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-lyxose ketol isomerase" /protein_id="NP_388301.1" /db_xref="EnsemblGenomes-Gn:BSU04200" /db_xref="EnsemblGenomes-Tr:CAB12227" /db_xref="GOA:P96578" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="PDB:2Y0O" /db_xref="SubtiList:BG12053" /db_xref="UniProtKB/Swiss-Prot:P96578" /translation="MGITKEEVNSYYQKAGIVLTDEEVDQIQLMDYGLGKERKVGLQL FVYVNTDRYCSKELVLFPGQTCPEHRHPPVDGQEGKQETFRCRYGKVYLYVEGEKTPL PKVLPPQEDREHYTVWHEIELEPGGQYTIPPNTKHWFQAGEEGAVVTEMSSTSTDKHD IFTDPRI*" /label="lyxE CDS" gene 454152..454655 /gene="lyxE" /locus_tag="BSU_04200" /old_locus_tag="BSU04200" /label="lyxE gene" downshifts 454636 /Source="Nicolas_upshifts" /id="D191" /incds=0 /nref=16 /ntot=26 /MaxReadThrough="4.81615" /MaxDrop="6.21035" /score="29.8440619" /energy="-15.5" /TU="U325" /idTUdmin="U325" /TUdmin="-683" /isTUend="FALSE" /label="downshifts" promotor_-35 454684..454691 /Source="Nicolas_upshift_promotors" /id="U326" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2929 /SigmaFactorBS="agaatataaggatgggcttaacagcccatcctttttgTATTG AAAaaaacagaatcatCGCTATAATGGGTAAAAAAGgaaagagggcgaggcaatgttc a" /listShort="ydaF, ydaG, S140" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 454705..454724 /Source="Nicolas_upshift_promotors" /id="U326" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2929 /SigmaFactorBS="agaatataaggatgggcttaacagcccatcctttttgTATTG AAAaaaacagaatcatCGCTATAATGGGTAAAAAAGgaaagagggcgaggcaatgttc a" /listShort="ydaF, ydaG, S140" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 454707 /Source="Nicolas_upshifts" /id="U326" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2929 /SigmaFactorBS="agaatataaggatgggcttaacagcccatcctttttgTATTG AAAaaaacagaatcatCGCTATAATGGGTAAAAAAGgaaagagggcgaggcaatgttc a" /listShort="ydaF, ydaG, S140" /GFF_Attribute="listLong" /label="upshifts" CDS 454741..455292 /gene="ydaF" /locus_tag="BSU_04210" /old_locus_tag="BSU04210" /EC_number="2.3.1.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15468321; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ribosomal protein N-acetyltransferase" /protein_id="NP_388302.1" /db_xref="EnsemblGenomes-Gn:BSU04210" /db_xref="EnsemblGenomes-Tr:CAB12228" /db_xref="GOA:P96579" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="PDB:1NSL" /db_xref="SubtiList:BG12054" /db_xref="UniProtKB/Swiss-Prot:P96579" /translation="MFTCKVNEHITIRLLEPKDAERLAELIIQNQQRLGKWLFFAENP SSADTYRETIIPDWRRQYADLNGIEAGLLYDGSLCGMISLHNLDQVNRKAEIGYWIAK EFEGKGIITAACRKLITYAFEELELNRVAICAAVGNEKSRAVPERIGFLEEGKARDGL YVNGMHHDLVYYSLLKREWEGEK*" /label="ydaF CDS" gene 454741..455292 /gene="ydaF" /locus_tag="BSU_04210" /old_locus_tag="BSU04210" /label="ydaF gene" promotor_-35 455307..455313 /Source="Nicolas_upshift_promotors" /id="U327" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=268 /SigmaFactorBS="ggcgaaaaataaagagcacactttctTGTTTAAatcttcccc ggatgTGGAAAAGTAACAGCGGAGacgttaaaaaggagtgattcgagatgaatcagca a" /listShort="ydaG, S140" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 455328..455346 /Source="Nicolas_upshift_promotors" /id="U327" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=268 /SigmaFactorBS="ggcgaaaaataaagagcacactttctTGTTTAAatcttcccc ggatgTGGAAAAGTAACAGCGGAGacgttaaaaaggagtgattcgagatgaatcagca a" /listShort="ydaG, S140" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 455341 /Source="Nicolas_upshifts" /id="U327" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=268 /SigmaFactorBS="ggcgaaaaataaagagcacactttctTGTTTAAatcttcccc ggatgTGGAAAAGTAACAGCGGAGacgttaaaaaggagtgattcgagatgaatcagca a" /listShort="ydaG, S140" /GFF_Attribute="listLong" /label="upshifts" CDS 455370..455792 /gene="ydaG" /locus_tag="BSU_04220" /old_locus_tag="BSU04220" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10220166; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative general stress protein" /protein_id="NP_388303.1" /db_xref="EnsemblGenomes-Gn:BSU04220" /db_xref="EnsemblGenomes-Tr:CAB12229" /db_xref="GOA:P80238" /db_xref="InterPro:IPR012349" /db_xref="SubtiList:BG19017" /db_xref="UniProtKB/Swiss-Prot:P80238" /translation="MNQQDIKQKVLDVLDHHKVGSLATVQKGKPHSRYMTFFHDGLTI YTPTSKETHKAEEIENNPNVHILLGYDCEGFGDAYVEVAGKAKINNSAELKDKIWSSK LERWFDGKDDPNLVILEIEPEDIRLMNAGEKTPVSLEL*" /label="ydaG CDS" gene 455370..455792 /gene="ydaG" /locus_tag="BSU_04220" /old_locus_tag="BSU04220" /label="ydaG gene" promotor_-35 455797..455805 /Source="Nicolas_upshift_promotors" /id="U328" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.753246753246753" /psig="0.993006993006993" /xcortree=273 /SigmaFactorBS="gtctcactcgaactataaaaaaTTTGTGTTTtcaggggcgaT ATGTTATTATGAATAGCTAgtaagaaaaataagcaaataaaaaagaaagtaaacttct t" /listShort="S140" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 455816..455835 /Source="Nicolas_upshift_promotors" /id="U328" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.753246753246753" /psig="0.993006993006993" /xcortree=273 /SigmaFactorBS="gtctcactcgaactataaaaaaTTTGTGTTTtcaggggcgaT ATGTTATTATGAATAGCTAgtaagaaaaataagcaaataaaaaagaaagtaaacttct t" /listShort="S140" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 455835..456201 /Source="Nicolas_S_feature" /locus_tag="new_474268_474634" /HighExp="Etha, Salt, Cold, Sw, B60, Gly, M9-stat, LPhT, B36, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB, SigA" /TUshortPSig="0.993, 0.999, 1" /TUlongSig="SigB" /TUlongPSig=1 /label="S140" upshifts 455835 /Source="Nicolas_upshifts" /id="U328" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.753246753246753" /psig="0.993006993006993" /xcortree=273 /SigmaFactorBS="gtctcactcgaactataaaaaaTTTGTGTTTtcaggggcgaT ATGTTATTATGAATAGCTAgtaagaaaaataagcaaataaaaaagaaagtaaacttct t" /listShort="S140" /GFF_Attribute="listLong" /label="upshifts" promotor_no_box complement(455861..455961) /Source="Nicolas_upshift_promotors" /id="U329" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.725274725274725" /psig="0.010989010989011" /xcortree=121 /SigmaFactorBS="aggggcgatttgttatgaaggaaaagaataagggcagctggt tatgctgcttgggaagcggtaagcttctctctcaaaacagaaaaaagaagtttacttt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" misc_RNA complement(455896..456164) /gene="bsrC" /locus_tag="BSU_misc_RNA_64" /product="small regulatory RNA" /experiment="publication(s) with functional evidences, PMID:18948176, 23457461" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18948176, 23457461; Product type n: RNA" /label="bsrC RNA" gene complement(455896..456164) /gene="bsrC" /locus_tag="BSU_misc_RNA_64" /label="bsrC gene" upshifts complement(455901) /Source="Nicolas_upshifts" /id="U329" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.725274725274725" /psig="0.010989010989011" /xcortree=121 /SigmaFactorBS="aggggcgatttgttatgaaggaaaagaataagggcagctggt tatgctgcttgggaagcggtaagcttctctctcaaaacagaaaaaagaagtttacttt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 456158 /Source="Nicolas_upshifts" /id="D192" /incds=0 /nref=124 /ntot=275 /MaxReadThrough="2.67264" /MaxDrop="7.35087" /score="29.9942993" /energy="-12" /TU="NA" /idTUdmin="U326" /TUdmin=3 /isTUend="TRUE" /label="downshifts" promotor_-35 456238..456247 /Source="Nicolas_upshift_promotors" /id="U330" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1651 /SigmaFactorBS="gacggtttttttattgcaaaaaacacatcgtacTGAAACCTC CttgtcttctttcCAGTCTTATCTCTAGGatgaaattggaggaagaataacgtgcatg t" /listShort="ydaH, lrpC, topB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 456260..456275 /Source="Nicolas_upshift_promotors" /id="U330" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1651 /SigmaFactorBS="gacggtttttttattgcaaaaaacacatcgtacTGAAACCTC CttgtcttctttcCAGTCTTATCTCTAGGatgaaattggaggaagaataacgtgcatg t" /listShort="ydaH, lrpC, topB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 456265 /Source="Nicolas_upshifts" /id="U330" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1651 /SigmaFactorBS="gacggtttttttattgcaaaaaacacatcgtacTGAAACCTC CttgtcttctttcCAGTCTTATCTCTAGGatgaaattggaggaagaataacgtgcatg t" /listShort="ydaH, lrpC, topB" /GFF_Attribute="listLong" /label="upshifts" CDS 456298..457107 /gene="amj" /locus_tag="BSU_04230" /old_locus_tag="BSU04230" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 25918422, 27537185" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 25918422, 27537185; Product type t: transporter" /codon_start=1 /transl_table=11 /product="lipid II flippase" /protein_id="NP_388304.1" /db_xref="EnsemblGenomes-Gn:BSU04230" /db_xref="EnsemblGenomes-Tr:CAB12230" /db_xref="GOA:P96581" /db_xref="InterPro:IPR021260" /db_xref="SubtiList:BG12055" /db_xref="UniProtKB/Swiss-Prot:P96581" /translation="MHVITTQVLFIFCFLLLIHSIETLAYATRLSGARVGFIASALSL FNVMVIVSRMSNMVQQPFTGHLIDDAGKNALAIVGEQFRFLIFGSTVGTILGIILLPS FVALFSRAIIHLAGGGGSVFQVFRKGFSKQGFKNALSYLRLPSISYVKGFHMRLIPKR LFVINMLITSIYTIGVLSALYAGLLAPERSTTAVMASGLINGIATMLLAIFVDPKVSV LADDVAKGKRSYIYLKWTSVTMVTSRVAGTLLAQLMFIPGAYYIAWLTKWF*" /label="amj CDS" gene 456298..457107 /gene="amj" /locus_tag="BSU_04230" /old_locus_tag="BSU04230" /label="amj gene" downshifts 457088 /Source="Nicolas_upshifts" /id="D193" /incds=0 /nref=5 /ntot=103 /MaxReadThrough="2.92236" /MaxDrop="3.54247" /score="15.7032536" /energy="-14.9" /TU="U330" /idTUdmin="U327" /TUdmin=911 /isTUend="FALSE" /label="downshifts" CDS complement(457151..457441) /gene="ydzA" /locus_tag="BSU_04240" /old_locus_tag="BSU04240" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388305.1" /db_xref="EnsemblGenomes-Gn:BSU04240" /db_xref="EnsemblGenomes-Tr:CAB12231" /db_xref="GOA:O31485" /db_xref="InterPro:IPR023845" /db_xref="SubtiList:BG12807" /db_xref="UniProtKB/Swiss-Prot:O31485" /translation="MLHTPIGRLRTMGFIEGMSLLILLFIAMPLKYWAGLPLAVTIVG SVHGGLFILYLLVLAYATFSVKWPLKWSAAGFIAAFVPFGNFLYDRGLRNYK*" /label="ydzA CDS" gene complement(457151..457441) /gene="ydzA" /locus_tag="BSU_04240" /old_locus_tag="BSU04240" /label="ydzA gene" downshifts complement(457155) /Source="Nicolas_upshifts" /id="D194" /incds=0 /nref=235 /ntot=260 /MaxReadThrough="1.23465" /MaxDrop="7.74945" /score="10.1798531" /energy="-14.9" /TU="NA" /idTUdmin="U332" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(457469..457488) /Source="Nicolas_upshift_promotors" /id="U332" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.653346653346653" /psig="0.967032967032967" /xcortree=1622 /SigmaFactorBS="catgtaaaaatgaatgttttccgaacattttttgaaagctgt catatgcccccccggATTGTTTATAGTATAAAATGaaaacgtgtccacaaggagggcg a" /listShort="ydzA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" misc_feature 457469..457487 /Source="Nicolas_upshift_promotors" /id="U331" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.343656343656344" /psig="0.691308691308691" /xcortree=306 /SigmaFactorBS="aagtcttccgatcggcgtgtgcagcataaatcgccctccttg tggacacgttttCATTTTATACTATAAACAAtccgggggggcatatgacagctttcaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 457475 /Source="Nicolas_upshifts" /id="U331" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.343656343656344" /psig="0.691308691308691" /xcortree=306 /SigmaFactorBS="aagtcttccgatcggcgtgtgcagcataaatcgccctccttg tggacacgttttCATTTTATACTATAAACAAtccgggggggcatatgacagctttcaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(457485) /Source="Nicolas_upshifts" /id="U332" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.653346653346653" /psig="0.967032967032967" /xcortree=1622 /SigmaFactorBS="catgtaaaaatgaatgttttccgaacattttttgaaagctgt catatgcccccccggATTGTTTATAGTATAAAATGaaaacgtgtccacaaggagggcg a" /listShort="ydzA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 457563..457570 /Source="Nicolas_upshift_promotors" /id="U333" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.765234765234765" /psig="0.999000999001" /xcortree=2269 /SigmaFactorBS="aacattcatttttacatgccttttctagggaactgTACTTGT CatttacaaaaataCCCGAGATAATGTGTACAAAatcaaaaaagaaggatgttgaaat g" /listShort="lrpC, topB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 457584..457603 /Source="Nicolas_upshift_promotors" /id="U333" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.765234765234765" /psig="0.999000999001" /xcortree=2269 /SigmaFactorBS="aacattcatttttacatgccttttctagggaactgTACTTGT CatttacaaaaataCCCGAGATAATGTGTACAAAatcaaaaaagaaggatgttgaaat g" /listShort="lrpC, topB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 457588 /Source="Nicolas_upshifts" /id="U333" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.765234765234765" /psig="0.999000999001" /xcortree=2269 /SigmaFactorBS="aacattcatttttacatgccttttctagggaactgTACTTGT CatttacaaaaataCCCGAGATAATGTGTACAAAatcaaaaaagaaggatgttgaaat g" /listShort="lrpC, topB" /GFF_Attribute="listLong" /label="upshifts" CDS 457626..458060 /gene="lrpC" /locus_tag="BSU_04250" /old_locus_tag="BSU04250" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9341680, 10606655, 10913073, 12458218, 16407330, 16528101" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9341680, 10606655, 10913073, 12458218, 16407330, 16528101; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (Lrp/AsnC family)" /protein_id="NP_388306.1" /db_xref="EnsemblGenomes-Gn:BSU04250" /db_xref="EnsemblGenomes-Tr:CAB12232" /db_xref="GOA:P96582" /db_xref="InterPro:IPR000485" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR019887" /db_xref="InterPro:IPR019888" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2CFX" /db_xref="SubtiList:BG12056" /db_xref="UniProtKB/Swiss-Prot:P96582" /translation="MKLDQIDLNIIEELKKDSRLSMRELGRKIKLSPPSVTERVRQLE SFGIIKQYTLEVDQKKLGLPVSCIVEATVKNADYERFKSYIQTLPNIEFCYRIAGAAC YMLKINAESLEAVEDFINKTSPYAQTVTHVIFSEIDTKNGRG*" /label="lrpC CDS" gene 457626..458060 /gene="lrpC" /locus_tag="BSU_04250" /old_locus_tag="BSU04250" /label="lrpC gene" promotor_-35 458057..458060 /Source="Nicolas_upshift_promotors" /id="U334" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.685314685314685" /psig="0.988011988011988" /xcortree=2491 /SigmaFactorBS="cgtcactcacgtcattttctcagaaattgacacgaaaaacgg gcgcggTTAGagagtgccgcgcgaagTCTGTTATAATAACAGGATGagcgtgaaagaa a" /listShort="topB, S141, ydaJ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 458069 /Source="Nicolas_upshifts" /id="U334" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.685314685314685" /psig="0.988011988011988" /xcortree=2491 /SigmaFactorBS="cgtcactcacgtcattttctcagaaattgacacgaaaaacgg gcgcggTTAGagagtgccgcgcgaagTCTGTTATAATAACAGGATGagcgtgaaagaa a" /listShort="topB, S141, ydaJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 458077..458096 /Source="Nicolas_upshift_promotors" /id="U334" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.685314685314685" /psig="0.988011988011988" /xcortree=2491 /SigmaFactorBS="cgtcactcacgtcattttctcagaaattgacacgaaaaacgg gcgcggTTAGagagtgccgcgcgaagTCTGTTATAATAACAGGATGagcgtgaaagaa a" /listShort="topB, S141, ydaJ" /GFF_Attribute="listLong" /label="promotor_-10" CDS 458125..460308 /gene="topB" /locus_tag="BSU_04260" /old_locus_tag="BSU04260" /EC_number="5.99.1.2" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 16192570, 16556226; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA topoisomerase III" /protein_id="NP_388307.1" /db_xref="EnsemblGenomes-Gn:BSU04260" /db_xref="EnsemblGenomes-Tr:CAB12233" /db_xref="GOA:P96583" /db_xref="InterPro:IPR000380" /db_xref="InterPro:IPR003601" /db_xref="InterPro:IPR003602" /db_xref="InterPro:IPR005738" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR013497" /db_xref="InterPro:IPR013825" /db_xref="InterPro:IPR023405" /db_xref="InterPro:IPR023406" /db_xref="InterPro:IPR034144" /db_xref="SubtiList:BG11979" /db_xref="UniProtKB/Swiss-Prot:P96583" /translation="MSKTVVLAEKPSVGRDLARVLKCHKKGNGYLEGDQYIVTWALGH LVTLADPEGYGKEFQSWRLEDLPIIPEPLKLVVIKKTGKQFNAVKSQLTRKDVNQIVI ATDAGREGELVARWIIEKANVRKPIKRLWISSVTDKAIKEGFQKLRSGKEYENLYHSA VARAEADWIVGINATRALTTKFNAQLSCGRVQTPTLAMIAKREADIQAFTPVPYYGIR AAVDGMTLTWQDKKSKQTRTFNQDVTSRLLKNLQGKQAVVAELKKTAKKSFAPALYDL TELQRDAHKRFGFSAKETLSVLQKLYEQHKLVTYPRTDSRFLSSDIVPTLKDRLEGME VKPYAQYVSQIKKRGIKSHKGYVNDAKVSDHHAIIPTEEPLVLSSLSDKERKLYDLIA KRFLAVLMPAFEYEETKVIAEIGGETFTAKGKTVQSQGWKAVYDMAEEDDEQEDDRDQ TLPALQKGDTLAVRTLTETSGQTKPPARFNEGTLLSAMENPSAFMQGEEKGLVKTLGE TGGLGTVATRADIIEKLFNSFLIEKKGQDIFITSKGKQLLQLVPEDLKSPALTAEWEQ KLSAIAAGKLKSAVFIKDMKAYAHQTVKEIKNSSQTFRHDNITGTACPECGKMMLKVN GKRGTMLVCQDRECGSRKTIARKTNARCPNCHKRMELRGQGEGQTFACVCGHREKLSV FEKRKNKDKARATKRDVSSYMKKQNKDEPINNALAEQLKKLGLDK*" /label="topB CDS" gene 458125..460308 /gene="topB" /locus_tag="BSU_04260" /old_locus_tag="BSU04260" /label="topB gene" downshifts 460291 /Source="Nicolas_upshifts" /id="D195" /incds=0 /nref=133 /ntot=245 /MaxReadThrough="3.22367" /MaxDrop="6.18597" /score="23.5229393" /energy="-10.4" /TU="U334" /idTUdmin="U333" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 460357..460363 /Source="Nicolas_upshift_promotors" /id="U335" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=179 /SigmaFactorBS="tgtgcctatcgcacaggttttttattggacttaggtccTGTT TTCttaatgttcaaaaaGGGAAAAAAAAGCTAGCAAtctgcattttttttcttttata g" /listShort="S141, ydaJ, ydaK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 460378..460396 /Source="Nicolas_upshift_promotors" /id="U335" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=179 /SigmaFactorBS="tgtgcctatcgcacaggttttttattggacttaggtccTGTT TTCttaatgttcaaaaaGGGAAAAAAAAGCTAGCAAtctgcattttttttcttttata g" /listShort="S141, ydaJ, ydaK" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 460379..460510 /Source="Nicolas_S_feature" /locus_tag="new_478812_478943" /HighExp="Etha, Salt, Heat, Cold, H2O2, G180, LPhT, Oxctl, Paraq, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="1, 0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S141" upshifts 460379 /Source="Nicolas_upshifts" /id="U335" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=179 /SigmaFactorBS="tgtgcctatcgcacaggttttttattggacttaggtccTGTT TTCttaatgttcaaaaaGGGAAAAAAAAGCTAGCAAtctgcattttttttcttttata g" /listShort="S141, ydaJ, ydaK" /GFF_Attribute="listLong" /label="upshifts" CDS 460511..461599 /gene="epsJ" /locus_tag="BSU_04270" /old_locus_tag="BSU04270" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15661000, 26078454, 27897378" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15661000, 26078454, 27897378; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="glycosyl hydrolase lipoprotein" /protein_id="NP_388308.1" /db_xref="EnsemblGenomes-Gn:BSU04270" /db_xref="EnsemblGenomes-Tr:CAB12234" /db_xref="GOA:O31486" /db_xref="InterPro:IPR008928" /db_xref="SubtiList:BG12057" /db_xref="UniProtKB/Swiss-Prot:O31486" /translation="MRHVLIAVILFFLSIGLSAGCAEAGNKTQNQSATEVNASPLQPA EYFIYHNLMNDKGLIKTDFSDQPSYLSESLGLWMEFLLSKNDAPHFQDQYQHLTDSFL MSNHLVTWKIQNGQASGTNALIDDMRIMLSLDQAAAKWGRSDYAQTARDIGTSLKTYN MNNGFFTDFYDSQAASKDVTLSYVMPDALAVLKKNGIIDEETEQRNANVLYSAPLKNG FLPKTYSSETKEYTYDSEINLIDQLYAAWHLPEGDEKASVLADWIKQEFQKNGKLYGR YSAYTKEPAVQYESPSVYALAVLFLTKQHENSSVIKAIYDRMNDFEIHDPVKSYYGGY MSGTQTHSFDNLLPLLAERKLFNENIIQ*" /label="epsJ CDS" gene 460511..461599 /gene="epsJ" /locus_tag="BSU_04270" /old_locus_tag="BSU04270" /label="epsJ gene" CDS 461580..462431 /gene="epsK" /locus_tag="BSU_04280" /old_locus_tag="BSU04280" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:23893111, 27897378" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23893111, 27897378; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="cyclic-di-GMP receptor" /protein_id="NP_388309.1" /db_xref="EnsemblGenomes-Gn:BSU04280" /db_xref="EnsemblGenomes-Tr:CAB12235" /db_xref="GOA:P96585" /db_xref="InterPro:IPR000160" /db_xref="InterPro:IPR029787" /db_xref="SubtiList:BG12058" /db_xref="UniProtKB/Swiss-Prot:P96585" /translation="MKISFSESQKLFAYFSGLIAALSLFIYYVSAQQSEGALILCITF GVIAAGIWFGPIYALAVTLIVLFVLGTLMMFFQTGQTSLFPAEEGLRMLVVWGIALLL FSFISGRIHDITAELRRSMTRLQSEIKSYVAVDRVTGFDNKQRMKLELSEEIKRAERY GNSFVFLLLHMHYFKEFKSLYGEKETDRLFQYVGQQIRTSVRETDKKFRPSDERIGIV LTHTPAEHMPAVLTKLKKQLDTYQLENGKYVSLTFHVCYLPYRNDIQTADQFLEELEN EMMMNEL*" /label="epsK CDS" gene 461580..462431 /gene="epsK" /locus_tag="BSU_04280" /old_locus_tag="BSU04280" /label="epsK gene" CDS 462442..464151 /gene="ydaL" /locus_tag="BSU_04290" /old_locus_tag="BSU04290" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 27897378; Product type ph :phenotype" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388310.1" /db_xref="EnsemblGenomes-Gn:BSU04290" /db_xref="EnsemblGenomes-Tr:CAB12236" /db_xref="GOA:O31487" /db_xref="InterPro:IPR018763" /db_xref="SubtiList:BG12059" /db_xref="UniProtKB/Swiss-Prot:O31487" /translation="MLCVMMLLFSAIASFPVSAQAKDQDAGILIIYSTLDGKESSQVK MLDLLAGHFTSHVTVKKDSDVEASDFKGKDHVIYYGQTKRKLSQKLLSLISGVKKPVV AIGYNAGQISQFSGLSLARKENVFQVHSRSEKADVSLESGLNVLSVSGLKGTALYTFK ADEGTTHSFIWKTKKGNVYIGLTNLLNDNLIVAKQLREAFGEKAGTTLLYLRLEDISP MSDEKLLLQAGTYLHKRHIPFILAVIPVYLNPETGDKVYLSNQPKMVKVLKKLQSMGG SIIVHGYTHAYRYSETGEGFEFWDAKADQPITSGNAEDPPSILEKEQDFPNEQAYHSY LEPFREKEETYTKQKLTRAIEDLTSSGLYPLAFEAPHYTMSEYGYQIASQYFTSIFGQ VQLSSTTWKTSGAPPFVTAPSMLHGMTLYPETIGFVDTSKQNPLGEMEEHISQMIDFE GGVAGGFYHPYLGMKYLPELVDQMERIPDSEWLDLKKTKQTVKTDKVEIHTSGDGTIQ VKNGVSPIYEFFDHHRQTPLEKALWILSAVVLLFVIMFVSYTFYLRATLKKRIFKERR SLG*" /label="ydaL CDS" gene 462442..464151 /gene="ydaL" /locus_tag="BSU_04290" /old_locus_tag="BSU04290" /label="ydaL gene" CDS 464144..465406 /gene="ydaM" /locus_tag="BSU_04300" /old_locus_tag="BSU04300" /EC_number="2.4.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 27897378, 28296273; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase associated to biofilm formation" /protein_id="NP_388311.1" /db_xref="EnsemblGenomes-Gn:BSU04300" /db_xref="EnsemblGenomes-Tr:CAB12237" /db_xref="GOA:P96587" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG12060" /db_xref="UniProtKB/Swiss-Prot:P96587" /translation="MGNTLFFISLSLIWVMLLYHMFLMQGGFRHYMTFERNIPKWREN MKELPKVSVLIPAHNEEVVIRQTLKAMVNLYYPKDRLEIIVVNDNSSDRTGDIVNEFS EKYDFIKMVITKPPNAGKGKSSALNSGFAESNGDVICVYDADNTPEKMAVYYLVLGLM NDEKAGAVVGKFRVINAAKTLLTRFINIETICFQWMAQGGRWKWFKIATIPGTNFAIR RSIIEKLGGWDDKALAEDTELTIRVYNLGYHIRFFPAAITWEQEPETWKVWWRQRTRW ARGNQYVVLKFLAQFFKLKRKRIIFDLFYFFFTYFLFFFGVIMSNAIFVVNLFYDLHL SVGFLAMILWILAFFLFMTEVMITLSIEKTEMNKQNFFIVFLMYFTYSQAWIVLVIYS LFVEIKHRLFKQEVKWYKTERYNQHKSG*" /label="ydaM CDS" gene 464144..465406 /gene="ydaM" /locus_tag="BSU_04300" /old_locus_tag="BSU04300" /label="ydaM gene" CDS 465412..467523 /gene="ydaN" /locus_tag="BSU_04310" /old_locus_tag="BSU04310" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 27897378; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative regulator of exopolysaccharide synthesis" /protein_id="NP_388312.1" /db_xref="EnsemblGenomes-Gn:BSU04310" /db_xref="EnsemblGenomes-Tr:CAB12238" /db_xref="GOA:O31488" /db_xref="InterPro:IPR008979" /db_xref="InterPro:IPR018513" /db_xref="SubtiList:BG12061" /db_xref="UniProtKB/Swiss-Prot:O31488" /translation="MKQIMIFLTSFMLLAMTGQTALAKDVQVSGSLLGKSSQEQAKQQ VLTSELITLYGSKDSAELTYQIPAGASSGNQQLVIEYEASNLLISPSSLTVVIDDEPV KTLKLDGDSKRKTVKLNLNKSQSAQGYHNVSLKFYGVMKEGVCVRQDTSGNWIKIYPD SRLTLADSSEAKGTSLDHYPYPFAQSGNTAEETAIVIPDNPSSAEIEAAVKTEGYLKT VDSSVSIAYVTESELKKIDKPTIVIGVDKHWNGKVKKLLKQAGLQAKGENLLLAERVL KAEGKQQPVLFAQAASEDALTKKISVMTDQTYTGQLSGDTLSISKLQQTEKKESDKLT LENFGAGDITIGADKTSSAHYFYPASAVLDENQSAKLSLKLKKSETIQASTAENESAS QAAELKVMINGQPHSVRLDELGKEDKNGFYHVTVKVDPKLLQKNRYIDIQFVTTGLKE NNPCNTTDEEKWVFIDKNSTLSYAIKGMSPSADFQEWPLPYAGNQDQTTLIVLPDTVS QSKLEELSLVTESFGNEAQHSYTVKKSSDVTANDAKGRNLIFIGGINQFSLLKEKSSD LLVPQEKNGSFDVSSFEMLNETTKQVVFTQASVWDSRYTMAVFAPSKGDGTAVTKEII SYLNSNDESATVLNETNSQQVFTNHQQLKSETNSSDAEQPTQDHSQKWMYIGVLALIM VVAAVFIWIAVRRKKRKTDTE*" /label="ydaN CDS" gene 465412..467523 /gene="ydaN" /locus_tag="BSU_04310" /old_locus_tag="BSU04310" /label="ydaN gene" downshifts 467507 /Source="Nicolas_upshifts" /id="D196" /incds=0 /nref=18 /ntot=91 /MaxReadThrough="0.438479999999999" /MaxDrop="4.36576" /score="34.1370207" /energy="-9.9" /TU="NA" /idTUdmin="U336" /TUdmin="-4598" /isTUend="FALSE" /label="downshifts" promotor_-35 467620..467627 /Source="Nicolas_upshift_promotors" /id="U336" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.976023976023976" /psig="0.998001998001998" /xcortree=2720 /SigmaFactorBS="cattttatttttttctctcagccaataagccTCTTTACAacg tgcgggaacggGAGTATGATCTCTTTTAGAAaacaaatcgcttaatctgaaatcagag c" /listShort="NA, S142, ydaO, mutT, ydaP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 467642..467661 /Source="Nicolas_upshift_promotors" /id="U336" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.976023976023976" /psig="0.998001998001998" /xcortree=2720 /SigmaFactorBS="cattttatttttttctctcagccaataagccTCTTTACAacg tgcgggaacggGAGTATGATCTCTTTTAGAAaacaaatcgcttaatctgaaatcagag c" /listShort="NA, S142, ydaO, mutT, ydaP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 467649 /Source="Nicolas_upshifts" /id="U336" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.976023976023976" /psig="0.998001998001998" /xcortree=2720 /SigmaFactorBS="cattttatttttttctctcagccaataagccTCTTTACAacg tgcgggaacggGAGTATGATCTCTTTTAGAAaacaaatcgcttaatctgaaatcagag c" /listShort="NA, S142, ydaO, mutT, ydaP" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 467659..467802 /gene="swaO" /locus_tag="BSU_misc_RNA_7" /product="ATP-, cyclic di-AMP-sensing riboswitch" /experiment="publication(s) with functional evidences, PMID:15096624, 20511502, 23086297, 25086507, 25086509" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15096624, 20511502, 23086297, 25086507, 25086509; Product type n: RNA" /function="16.3: Control" /label="swaO RNA" gene 467659..467802 /gene="swaO" /locus_tag="BSU_misc_RNA_7" /label="swaO gene" downshifts 467800 /Source="Nicolas_upshifts" /id="D197" /incds=0 /nref=10 /ntot=52 /MaxReadThrough="7.43698" /MaxDrop="5.83561" /score="30.4392599" /energy="-14.7" /TU="U336" /idTUdmin="U336" /TUdmin="-4305" /isTUend="FALSE" /label="downshifts" S_feature 467845..467998 /Source="Nicolas_S_feature" /locus_tag="new_486278_486431" /HighExp="LPhT, LBGstat, LPh, T-1.10H, T-0.40H, G135, G180, T-1.40H, G150, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S142" CDS 467999..469822 /gene="kimA" /locus_tag="BSU_04320" /old_locus_tag="BSU04320" /function="16.3: Control" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15096624, 15849754, 16850406, 20511502, 25086509, 26789423, 28420751" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15096624, 15849754, 16850406, 20511502, 25086509, 26789423, 28420751; Product type t: transporter" /codon_start=1 /transl_table=11 /product="cyclic di-AMP controlled transporter of potassium" /protein_id="NP_388313.1" /db_xref="EnsemblGenomes-Gn:BSU04320" /db_xref="EnsemblGenomes-Tr:CAB12239" /db_xref="GOA:P96589" /db_xref="InterPro:IPR002293" /db_xref="SubtiList:BG12062" /db_xref="UniProtKB/Swiss-Prot:P96589" /translation="MYHSIKRFLIGKPLKSQAAGEQKLTKLKALAMLSSDALSSVAYG TEQILIILATISAAAFWYSIPIAVGVLILLLALILSYRQIIYAYPQGGGAYIVSKENL GEKPGLIAGGSLLVDYILTVAVSISAGTDAITSAFPALHDYHVPIAIFLVLVIMILNL RGLSESASILAYPVYLFVVALLVLIAVGLFKLMTGQIDQPAHHTSLGTPVAGITLFLL LKAFSSGCSALTGVEAISNAIPAFKNPPARNAARTLAMMGILLAILFSGITVLAYGYG TAPKPDETVVSQIASETFGRNVFYYVIQGVTSLILVLAANTGFSAFPQLAFNLARDQY MPRMFTVRGDRLGFSNGIIFLGFASIVLIILFGGQTEHLIPLYAVGVFIPFTLSQTGM CMKWIKQKPKGWIGKMLINSCGALISFMVLSILFVTKFNVVWPVLIFMPIVVLLFFAI KNHYTAVGEQLRIVDKEPEEIKGTVVIVPVAGVTTVVQKSIHYAKSLSDQVIAVHVSF DREQEKKFEKRWEELNNGVRLVTLHSSYRSLVHPFDKFLETVEAKAKKEQFSVMVLFP QFITKKRWHTILHNQSAFLLRVRLFWKKDIMVATLPYHFKK*" /label="kimA CDS" gene 467999..469822 /gene="kimA" /locus_tag="BSU_04320" /old_locus_tag="BSU04320" /label="kimA gene" downshifts 469814 /Source="Nicolas_upshifts" /id="D198" /incds=0 /nref=50 /ntot=181 /MaxReadThrough="3.55206" /MaxDrop="4.7232" /score="6.00201196" /energy="-13.9" /TU="U336" /idTUdmin="U336" /TUdmin="-2291" /isTUend="FALSE" /label="downshifts" CDS 469881..470330 /gene="nudT" /locus_tag="BSU_04330" /old_locus_tag="BSU04330" /EC_number="3.6.1.-" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15576788, 16513759; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NTP pyrophosphohydrolase" /protein_id="NP_388314.1" /db_xref="EnsemblGenomes-Gn:BSU04330" /db_xref="EnsemblGenomes-Tr:CAB12240" /db_xref="GOA:P96590" /db_xref="InterPro:IPR000086" /db_xref="InterPro:IPR015797" /db_xref="InterPro:IPR020084" /db_xref="InterPro:IPR020476" /db_xref="SubtiList:BG11956" /db_xref="UniProtKB/Swiss-Prot:P96590" /translation="MYTQGAFVIVLNESQQILLVKRKDVPLWDLPGGRVDPGESAEEA AVREILEETGYNAALSAKIGVYQRPKFQDEQHLFFGSITGGQAMADGTETAGLKWVSP GRLPLFMVPNRKRQINDFKNGAQDVNVTVKDSGLLAAIDLLKRRLGK*" /label="nudT CDS" gene 469881..470330 /gene="nudT" /locus_tag="BSU_04330" /old_locus_tag="BSU04330" /label="nudT gene" promotor_-35 470343..470349 /Source="Nicolas_upshift_promotors" /id="U337" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=192 /SigmaFactorBS="tgttgaaaagaagactgggcaagtgattcaggtctccgGGTT TTAaagcctttctcctgTGGTATTGAAAAAAGGAAAaaggaggatacgttatggcaca c" /listShort="ydaP, S145" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 470364..470382 /Source="Nicolas_upshift_promotors" /id="U337" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=192 /SigmaFactorBS="tgttgaaaagaagactgggcaagtgattcaggtctccgGGTT TTAaagcctttctcctgTGGTATTGAAAAAAGGAAAaaggaggatacgttatggcaca c" /listShort="ydaP, S145" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 470365 /Source="Nicolas_upshifts" /id="U337" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=192 /SigmaFactorBS="tgttgaaaagaagactgggcaagtgattcaggtctccgGGTT TTAaagcctttctcctgTGGTATTGAAAAAAGGAAAaaggaggatacgttatggcaca c" /listShort="ydaP, S145" /GFF_Attribute="listLong" /label="upshifts" CDS 470397..472121 /gene="poxB" /locus_tag="BSU_04340" /old_locus_tag="BSU04340" /EC_number="1.2.3.3" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16291680, 16513748, 10220166, 23611909; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-phosphate generating pyruvate oxidase" /protein_id="NP_388315.1" /db_xref="EnsemblGenomes-Gn:BSU04340" /db_xref="EnsemblGenomes-Tr:CAB12241" /db_xref="GOA:P96591" /db_xref="InterPro:IPR000399" /db_xref="InterPro:IPR011766" /db_xref="InterPro:IPR012000" /db_xref="InterPro:IPR012001" /db_xref="InterPro:IPR029035" /db_xref="InterPro:IPR029061" /db_xref="SubtiList:BG12063" /db_xref="UniProtKB/Swiss-Prot:P96591" /translation="MAHKTAGQAMTELLEQWGVDHVYGIPGDSINEFIEELRHERNQL KFIQTRHEEVAALAAAAEAKLTGKIGVCLSIAGPGAVHLLNGLYDAKADGAPVLAIAG QVSSGEVGRDYFQEIKLEQMFEDVAVFNREVHSAESLPDLLNQAIRTAYSKKGVAVLS VSDDLFAEKIKREPVYTSPVYIEGNLEPKKEQLVTCAQYINNAKKPIILAGQGMKKAK RELLEFADKAAAPIVVTLPAKGVVPDKHPHFLGNLGQIGTKPAYEAMEECDLLIMLGT SFPYRDYLPDDTPAIQLDSDPAKIGKRYPVTAGLVCDSALGLRELTEYIERKEDRRFL NACTEHMQHWWNEIEKDETEATTPLKPQQVVARLQEAAADDAVLSVDVGTVTVWMARH FKMNANQDFIVSSWLATMGCGLPGAIAASLSEPERQAIAVCGDGGFSMVMQDLPTAVK YKLPITVVILNNENLGMIEYEQQVKGNIDYVTKLQNVDYAAFAESCGAKGIKVTKAEE LAPAFHEALHSDQPVVVDVMIGNEPPLPGKITYGQAKGFSKYMLKNFFENQKFEMPSL KKSLKRLF*" /label="poxB CDS" gene 470397..472121 /gene="poxB" /locus_tag="BSU_04340" /old_locus_tag="BSU04340" /label="poxB gene" S_feature complement(471233..472092) /Source="Nicolas_S_feature" /locus_tag="new_489666_490525_c" /HighExp="H2O2, Paraq, G180, G150, Oxctl, Diami, dia15, G135, C30, dia5" /AntisenseName="ydaP" /AntisenseCor="-5.0529608261635599E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigA" /TUshortPSig="0.113, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S143" S_feature complement(472094..472205) /Source="Nicolas_S_feature" /locus_tag="new_490527_490638_c" /HighExp="dia5, M0t45, S0, S2, S1, Paraq, GM 120, Lbstat, MG 5, UNK1" /AntisenseName="ydaP" /AntisenseCor="1.7026698118644101E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigA" /TUshortPSig="0.113, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S144" downshifts 472105 /Source="Nicolas_upshifts" /id="D199" /incds=0 /nref=50 /ntot=166 /MaxReadThrough="5.18566" /MaxDrop="6.66568" /score="7.55338633" /energy="-5.3" /TU="U337" /idTUdmin="U336" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(472113..472316) /locus_tag="BSU_04345" /old_locus_tag="BSU04345" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513943.1" /translation="MIRISMQGQMHLPLKQDAFVLLSVSSMAKSVPNTYTDHFMNSNM LKIHLFPKKKKKTRALRAPVFLK*" /label="hypothetical protein CDS" gene complement(472113..472316) /locus_tag="BSU_04345" /old_locus_tag="BSU04345" /label="gene" downshifts complement(472137) /Source="Nicolas_upshifts" /id="D200" /incds=0 /nref=5 /ntot=55 /MaxReadThrough="4.75809" /MaxDrop="8.06239" /score="11.2659249" /energy="-9.1" /TU="U338,U340,U341" /idTUdmin="U338" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" promotor_no_box complement(472165..472265) /Source="Nicolas_upshift_promotors" /id="U338" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.445554445554446" /psig="0.112887112887113" /xcortree=1496 /SigmaFactorBS="gcatttgtccttttgtctgtttcgagtatggcgaaatcagtt cctaatacatataccgatcattttatgaattcaaacatgctgaaaatacatttgtttc c" /listShort="S144, S143" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-35 472174..472179 /Source="Nicolas_upshift_promotors" /id="U339" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.914085914085914" /psig="0.914085914085914" /xcortree=1216 /SigmaFactorBS="tgtttttttttttttttttggaaacaaaTGTATTttcagcat gtttgaatTCATAAAATGATCGGTATAtgtattaggaactgatttcgccatactcgaa a" /listShort="S145" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 472196..472214 /Source="Nicolas_upshift_promotors" /id="U339" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.914085914085914" /psig="0.914085914085914" /xcortree=1216 /SigmaFactorBS="tgtttttttttttttttttggaaacaaaTGTATTttcagcat gtttgaatTCATAAAATGATCGGTATAtgtattaggaactgatttcgccatactcgaa a" /listShort="S145" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(472205) /Source="Nicolas_upshifts" /id="U338" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.445554445554446" /psig="0.112887112887113" /xcortree=1496 /SigmaFactorBS="gcatttgtccttttgtctgtttcgagtatggcgaaatcagtt cctaatacatataccgatcattttatgaattcaaacatgctgaaaatacatttgtttc c" /listShort="S144, S143" /GFF_Attribute="listLong" /label="upshifts" S_feature 472206..472421 /Source="Nicolas_S_feature" /locus_tag="new_490639_490854" /HighExp="Etha, S4, S8, S5, C30, S7, B60, S6, Salt, B36" /AntisenseName="ydzK" /AntisenseCor="3.8830946787094797E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigB" /TUshortPSig="0.914, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S145" upshifts 472206 /Source="Nicolas_upshifts" /id="U339" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.914085914085914" /psig="0.914085914085914" /xcortree=1216 /SigmaFactorBS="tgtttttttttttttttttggaaacaaaTGTATTttcagcat gtttgaatTCATAAAATGATCGGTATAtgtattaggaactgatttcgccatactcgaa a" /listShort="S145" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(472272..472343) /Source="Nicolas_S_feature" /locus_tag="new_490705_490776_c" /HighExp="Sw, B60, dia15, dia5, BI, Etha, BC, M9-stat, C90, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S146" downshifts complement(472315) /Source="Nicolas_upshifts" /id="D201" /incds=0 /nref=21 /ntot=191 /MaxReadThrough="5.39949" /MaxDrop="5.81865" /score="3.34912028" /energy="-20.3" /TU="U340,U341" /idTUdmin="U343" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(472344..472610) /gene="ydzK" /locus_tag="BSU_04359" /old_locus_tag="BSU04359" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="YP_003097680.1" /db_xref="EnsemblGenomes-Gn:BSU04359" /db_xref="EnsemblGenomes-Tr:CAX52551" /db_xref="GOA:C0H3V4" /db_xref="UniProtKB/Swiss-Prot:C0H3V4" /translation="MSVFILFYLWIVPIVIGILCSVAAHKSKGKMRVAPGIAMIVLSI ISLITAFTAGHTNFHVFIGGMFLFGTFLVGSAFPFFFGLKKKEK*" /label="ydzK CDS" gene complement(472344..472610) /gene="ydzK" /locus_tag="BSU_04359" /old_locus_tag="BSU04359" /label="ydzK gene" promotor_-10 complement(472626..472645) /Source="Nicolas_upshift_promotors" /id="U340" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.637362637362637" /psig=1 /xcortree=2076 /SigmaFactorBS="cttctaaagccggtttttatttttccgcaaaagctcattgAT ACCCTTtttgacagaaaTTTGTTATGATAGAAGAAAAatcggagttttgatgatgtca g" /listShort="ydzK, S146, S144, S143" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(472644) /Source="Nicolas_upshifts" /id="U340" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.637362637362637" /psig=1 /xcortree=2076 /SigmaFactorBS="cttctaaagccggtttttatttttccgcaaaagctcattgAT ACCCTTtttgacagaaaTTTGTTATGATAGAAGAAAAatcggagttttgatgatgtca g" /listShort="ydzK, S146, S144, S143" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(472657..472664) /Source="Nicolas_upshift_promotors" /id="U340" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.637362637362637" /psig=1 /xcortree=2076 /SigmaFactorBS="cttctaaagccggtttttatttttccgcaaaagctcattgAT ACCCTTtttgacagaaaTTTGTTATGATAGAAGAAAAatcggagttttgatgatgtca g" /listShort="ydzK, S146, S144, S143" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(472714..473991) /gene="mntH" /locus_tag="BSU_04360" /old_locus_tag="BSU04360" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12029030, 12950915, 14580210, 15849754, 16850406, 27573840, 27748968" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12029030, 12950915, 14580210, 15849754, 16850406, 27573840, 27748968; Product type t: transporter" /codon_start=1 /transl_table=11 /product="proton-coupled manganese transporter" /protein_id="NP_388317.1" /db_xref="EnsemblGenomes-Gn:BSU04360" /db_xref="EnsemblGenomes-Tr:CAB12243" /db_xref="GOA:P96593" /db_xref="InterPro:IPR001046" /db_xref="SubtiList:BG12065" /db_xref="UniProtKB/Swiss-Prot:P96593" /translation="MMNKDITAQSPRSKAVQDALDGKIRGFRGLLPFLGPAFIAAIAY IDPGNFATNISAGSKYGYMLLWVILFSNIMALLIQSLSAKLGIATGKNLPEVAREEFP KPVSIGLWIQGELVIIATDLAEFIGAALGLYLLFGIPMLEASIIAAIGSFAILELQRR GYRSLEAGIAGMLFVVVIAFALQTFFAKPDAVSVMKGLFVPAFHGTDSVLLAAGILGA TVMPHAIYLHSALTQRRVVGKTDAERKKIFRFEFIDILIAMLIAGAINASMLIVAAAL FFKNGLFVEDLDVAFQQFGHLVSPMSAALFGIGLLVAGLSSSSVGTLSGDVIMQGFIN YRIPLYVRRFITIIPPILIIASGVNPTTALVLSQVVLSFGIAFALIPLIMFTSNKRIM GSLINAKWITVVSWLIAVLIVALNVFLIVDTFR*" /label="mntH CDS" gene complement(472714..473991) /gene="mntH" /locus_tag="BSU_04360" /old_locus_tag="BSU04360" /label="mntH gene" downshifts complement(472733) /Source="Nicolas_upshifts" /id="D202" /incds=0 /nref=170 /ntot=242 /MaxReadThrough="5.8826" /MaxDrop="4.8109" /score="28.3182556" /energy="-9.6" /TU="U341,U343" /idTUdmin="U342" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(474053..474072) /Source="Nicolas_upshift_promotors" /id="U341" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig=1 /xcortree=1525 /SigmaFactorBS="ggaaaaattcagaagtgtattttgaacattttcGGTTGACAa gaaaccgggatGGTCATATGATGTAGATAAAataatttgccttaaggaaactctttgt t" /listShort="mntH, ydzK, S146, S144, S143" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(474065) /Source="Nicolas_upshifts" /id="U341" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig=1 /xcortree=1525 /SigmaFactorBS="ggaaaaattcagaagtgtattttgaacattttcGGTTGACAa gaaaccgggatGGTCATATGATGTAGATAAAataatttgccttaaggaaactctttgt t" /listShort="mntH, ydzK, S146, S144, S143" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(474067..474144) /Source="Nicolas_S_feature" /locus_tag="new_492500_492577_c" /HighExp="S6, S8, S7, Etha, S5, Salt, BT, Heat, B36, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigB" /TUshortPSig="1, 0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S147" promotor_-35 complement(474085..474092) /Source="Nicolas_upshift_promotors" /id="U341" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig=1 /xcortree=1525 /SigmaFactorBS="ggaaaaattcagaagtgtattttgaacattttcGGTTGACAa gaaaccgggatGGTCATATGATGTAGATAAAataatttgccttaaggaaactctttgt t" /listShort="mntH, ydzK, S146, S144, S143" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(474128..474147) /Source="Nicolas_upshift_promotors" /id="U342" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1312 /SigmaFactorBS="aggcatcgtttcgaaatgaaacgatgtctttttaTATGGGAC CTtatcacgaatcccTACATATCATGTTACATAACagggaaaaattcagaagtgtatt t" /listShort="S147, mntH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(474144) /Source="Nicolas_upshifts" /id="U342" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1312 /SigmaFactorBS="aggcatcgtttcgaaatgaaacgatgtctttttaTATGGGAC CTtatcacgaatcccTACATATCATGTTACATAACagggaaaaattcagaagtgtatt t" /listShort="S147, mntH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(474161..474170) /Source="Nicolas_upshift_promotors" /id="U342" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1312 /SigmaFactorBS="aggcatcgtttcgaaatgaaacgatgtctttttaTATGGGAC CTtatcacgaatcccTACATATCATGTTACATAACagggaaaaattcagaagtgtatt t" /listShort="S147, mntH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(474221..474478) /gene="ydaS" /locus_tag="BSU_04370" /old_locus_tag="BSU04370" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388318.1" /db_xref="EnsemblGenomes-Gn:BSU04370" /db_xref="EnsemblGenomes-Tr:CAB12244" /db_xref="GOA:P96594" /db_xref="InterPro:IPR007341" /db_xref="SubtiList:BG12066" /db_xref="UniProtKB/Swiss-Prot:P96594" /translation="MLSFLVSLVVAIVIGLIGSAIVGNRLPGGIFGSMIAGLIGAWIG HGLLGTWGPSLAGFAIFPAIIGAAIFVFLLGLIFRGLRKEA*" /label="ydaS CDS" gene complement(474221..474478) /gene="ydaS" /locus_tag="BSU_04370" /old_locus_tag="BSU04370" /label="ydaS gene" downshifts complement(474229) /Source="Nicolas_upshifts" /id="D203" /incds=0 /nref=7 /ntot=33 /MaxReadThrough="4.70076" /MaxDrop="4.7213" /score="7.04635537" /energy="-13.4" /TU="U343" /idTUdmin="U342" /TUdmin="-1496" /isTUend="FALSE" /label="downshifts" downshifts complement(474295) /Source="Nicolas_upshifts" /id="D204" /incds=1 /nref=2 /ntot=69 /MaxReadThrough="7.55545" /MaxDrop="2.8244" /score="7.04635537" /energy="-13.4" /TU="U343" /idTUdmin="U342" /TUdmin="-1562" /isTUend="FALSE" /label="downshifts" CDS complement(474556..475008) /gene="ydaT" /locus_tag="BSU_04380" /old_locus_tag="BSU04380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388319.1" /db_xref="EnsemblGenomes-Gn:BSU04380" /db_xref="EnsemblGenomes-Tr:CAB12245" /db_xref="InterPro:IPR018691" /db_xref="SubtiList:BG12067" /db_xref="UniProtKB/Swiss-Prot:P96595" /translation="MPWSMKDYPASLKNLEKPVRKKAIDIANAMIDEGYEEGRAIPIA TSKAKEWAENASTDEIDDFLTHDDETERDADPSSGSGPELMNKAEHVIKHKKGWAVKA EGAKRVSEIKDTKKEAIERAKEIAAHKGTEVIVHLADGSVQRKIKTGS*" /label="ydaT CDS" gene complement(474556..475008) /gene="ydaT" /locus_tag="BSU_04380" /old_locus_tag="BSU04380" /label="ydaT gene" promotor_-10 complement(475027..475045) /Source="Nicolas_upshift_promotors" /id="U343" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=230 /SigmaFactorBS="ttttttctactatatagtataccttcattttttcggatgCGT TTTTatttttcacctgcGGGTACCATTTTTATAAAAggaaaaggagtgatagacatgc c" /listShort="ydaT, ydaS, S147, mntH, ydzK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(475044) /Source="Nicolas_upshifts" /id="U343" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=230 /SigmaFactorBS="ttttttctactatatagtataccttcattttttcggatgCGT TTTTatttttcacctgcGGGTACCATTTTTATAAAAggaaaaggagtgatagacatgc c" /listShort="ydaT, ydaS, S147, mntH, ydzK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(475059..475065) /Source="Nicolas_upshift_promotors" /id="U343" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=230 /SigmaFactorBS="ttttttctactatatagtataccttcattttttcggatgCGT TTTTatttttcacctgcGGGTACCATTTTTATAAAAggaaaaggagtgatagacatgc c" /listShort="ydaT, ydaS, S147, mntH, ydzK" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 475077 /Source="Nicolas_upshifts" /id="U344" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.795204795204795" /psig="0.993006993006993" /xcortree=2375 /SigmaFactorBS="ctccttttccttttataaaaatggtacccgcaggtgaaaaat aaaaacgcatccgaaaaaatgaaggtATACTATATAGTAGAAAAAAcggaagggaagt g" /listShort="ydbA" /GFF_Attribute="listLong" /label="upshifts" misc_feature 475085..475104 /Source="Nicolas_upshift_promotors" /id="U344" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.795204795204795" /psig="0.993006993006993" /xcortree=2375 /SigmaFactorBS="ctccttttccttttataaaaatggtacccgcaggtgaaaaat aaaaacgcatccgaaaaaatgaaggtATACTATATAGTAGAAAAAAcggaagggaagt g" /listShort="ydbA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 475126..475944 /gene="ydbA" /locus_tag="BSU_04390" /old_locus_tag="BSU04390" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388320.1" /db_xref="EnsemblGenomes-Gn:BSU04390" /db_xref="EnsemblGenomes-Tr:CAB12246" /db_xref="InterPro:IPR024787" /db_xref="SubtiList:BG12068" /db_xref="UniProtKB/Swiss-Prot:P96596" /translation="MPTERKEDLHQQLKEIEKWEKDQQKVWFWEKLSRLPFQLLDKLT PEFIQKKIGKLLDEVGSFVQTGGQYLTSEKQIIRMFQKKLPEEIFESLEDIRKAPLPV MDEIAEGMGKNRTNAATVQGATTGVGGVFTLAADIPAVLGLSLKTLQDIAVAYGYDPK EKKERVFIVKCLQLTSADVVGKRSILQELKHYDQDRTYKNVASQIQGWREVVLGYRDT FGWKKLFQIVPVAGMVFGAAANRSTLNDITETGMMLYKKRRILERLKETEREME*" /label="ydbA CDS" gene 475126..475944 /gene="ydbA" /locus_tag="BSU_04390" /old_locus_tag="BSU04390" /label="ydbA gene" downshifts 475935 /Source="Nicolas_upshifts" /id="D205" /incds=0 /nref=118 /ntot=223 /MaxReadThrough="0.66117" /MaxDrop="4.41502" /score="5.38936313" /energy="-9.2" /TU="NA" /idTUdmin="U344" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 476012..476018 /Source="Nicolas_upshift_promotors" /id="U345" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=219 /SigmaFactorBS="ttttagtggaaacatacccaatgtgttttgttTGTTTAAaag aattgtgagcGGGAATACAACAACCAACAccaattaaaggaggaattcaaaatggcag a" /listShort="gsiB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 476032..476050 /Source="Nicolas_upshift_promotors" /id="U345" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=219 /SigmaFactorBS="ttttagtggaaacatacccaatgtgttttgttTGTTTAAaag aattgtgagcGGGAATACAACAACCAACAccaattaaaggaggaattcaaaatggcag a" /listShort="gsiB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 476040 /Source="Nicolas_upshifts" /id="U345" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=219 /SigmaFactorBS="ttttagtggaaacatacccaatgtgttttgttTGTTTAAaag aattgtgagcGGGAATACAACAACCAACAccaattaaaggaggaattcaaaatggcag a" /listShort="gsiB" /GFF_Attribute="listLong" /label="upshifts" CDS 476073..476444 /gene="gsiB" /locus_tag="BSU_04400" /old_locus_tag="BSU04400" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7651322, 9669336, 9763714, 12562800, 21421783" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7651322, 9669336, 9763714, 12562800, 21421783; Product type f: factor" /codon_start=1 /transl_table=11 /product="general stress protein glucose starvation induced" /protein_id="NP_388321.1" /db_xref="EnsemblGenomes-Gn:BSU04400" /db_xref="EnsemblGenomes-Tr:CAB12247" /db_xref="InterPro:IPR019626" /db_xref="SubtiList:BG10826" /db_xref="UniProtKB/Swiss-Prot:P26907" /translation="MADNNKMSREEAGRKGGETTSKNHDKEFYQEIGQKGGEATSKNH DKEFYQEIGEKGGEATSKNHDKEFYQEIGEKGGEATSENHDKEFYQEIGRKGGEATSK NHDKEFYQEIGSKGGNARNND*" /label="gsiB CDS" gene 476073..476444 /gene="gsiB" /locus_tag="BSU_04400" /old_locus_tag="BSU04400" /label="gsiB gene" downshifts complement(476077) /Source="Nicolas_upshifts" /id="D206" /incds=0 /nref=1 /ntot=25 /MaxReadThrough="1.50212" /MaxDrop="4.6705" /score="-7.76438364" /energy="-14.2" /TU="NA" /idTUdmin="U346" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 476461 /Source="Nicolas_upshifts" /id="D207" /incds=0 /nref=153 /ntot=219 /MaxReadThrough="3.75525" /MaxDrop="8.3301" /score="39.7307477" /energy="-16.6" /TU="U345" /idTUdmin="U345" /TUdmin="-24" /isTUend="FALSE" /label="downshifts" upshifts complement(476495) /Source="Nicolas_upshifts" /id="U346" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.738261738261738" /psig="0.00899100899100899" /xcortree=120 /SigmaFactorBS="cttattgtatctcaatagcggcataaattgagaagattccaa aaaaaagcgatcCAGCtgatgtgccggatcgcttttttatttacaggttgtctgcctt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(476498..476501) /Source="Nicolas_upshift_promotors" /id="U346" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.738261738261738" /psig="0.00899100899100899" /xcortree=120 /SigmaFactorBS="cttattgtatctcaatagcggcataaattgagaagattccaa aaaaaagcgatcCAGCtgatgtgccggatcgcttttttatttacaggttgtctgcctt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-35 476523..476530 /Source="Nicolas_upshift_promotors" /id="U347" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2941 /SigmaFactorBS="ggcacatcagctggatcgcttttttttggaatctTCTCAATT tatgccgctatTGAGATACAATAAGTGAAAAaggggttttcgctaatgtccaagatgc a" /listShort="ydbB, ydbC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 476542..476561 /Source="Nicolas_upshift_promotors" /id="U347" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2941 /SigmaFactorBS="ggcacatcagctggatcgcttttttttggaatctTCTCAATT tatgccgctatTGAGATACAATAAGTGAAAAaggggttttcgctaatgtccaagatgc a" /listShort="ydbB, ydbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 476549 /Source="Nicolas_upshifts" /id="U347" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2941 /SigmaFactorBS="ggcacatcagctggatcgcttttttttggaatctTCTCAATT tatgccgctatTGAGATACAATAAGTGAAAAaggggttttcgctaatgtccaagatgc a" /listShort="ydbB, ydbC" /GFF_Attribute="listLong" /label="upshifts" CDS 476576..476917 /gene="ydbB" /locus_tag="BSU_04410" /old_locus_tag="BSU04410" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10704478; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme; cupin family" /protein_id="NP_388322.1" /db_xref="EnsemblGenomes-Gn:BSU04410" /db_xref="EnsemblGenomes-Tr:CAB12248" /db_xref="GOA:P96597" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR013096" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR019780" /db_xref="SubtiList:BG12069" /db_xref="UniProtKB/Swiss-Prot:P96597" /translation="MSKMQNLLAIANEVKEKHANFSISEVNDHCVRLAVFTGEYDWHH HPDSDELFIVLEGELLIDFKDKETAVLKANDSLLIPKGTVHRTRSYVRTVNLCVEHKQ AETVIIEEQPC*" /label="ydbB CDS" gene 476576..476917 /gene="ydbB" /locus_tag="BSU_04410" /old_locus_tag="BSU04410" /label="ydbB gene" CDS 476911..477270 /gene="ydbC" /locus_tag="BSU_04420" /old_locus_tag="BSU04420" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388323.1" /db_xref="EnsemblGenomes-Gn:BSU04420" /db_xref="EnsemblGenomes-Tr:CAB12249" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR032555" /db_xref="SubtiList:BG12070" /db_xref="UniProtKB/Swiss-Prot:P96598" /translation="MLIKKMICEVDAANAEAFAKAQSQWEALSHISGFIKQAGGWRKT IDEPLTAEIISVWENREAYDHFMENEHDSIYEENDQKAVILSIEVTVYEEDKPFVHDL LHNPDIRYEPNWTVLKA*" /label="ydbC CDS" gene 476911..477270 /gene="ydbC" /locus_tag="BSU_04420" /old_locus_tag="BSU04420" /label="ydbC gene" S_feature complement(476973..477266) /Source="Nicolas_S_feature" /locus_tag="new_495406_495699_c" /HighExp="Etha, Salt, M9-stat, C30, Heat, Sw, B60, S8, C90, UNK1" /AntisenseName="ydbC" /AntisenseCor="0.16172626521480701" /AntisenseRegPval="-2.1" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S148" downshifts 477211 /Source="Nicolas_upshifts" /id="D208" /incds=0 /nref=2 /ntot=130 /MaxReadThrough="1.8663" /MaxDrop="2.67081" /score="39.7307477" /energy="-16.6" /TU="NA" /idTUdmin="U347" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 477255 /Source="Nicolas_upshifts" /id="D209" /incds=0 /nref=1 /ntot=28 /MaxReadThrough="0.252220000000001" /MaxDrop="2.61185" /score="39.7307477" /energy="-16.6" /TU="NA" /idTUdmin="U347" /TUdmin=44 /isTUend="FALSE" /label="downshifts" CDS complement(477307..478128) /gene="ydbD" /locus_tag="BSU_04430" /old_locus_tag="BSU04430" /EC_number="1.11.1.6" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15231799; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative manganese-containing catalase" /protein_id="NP_388324.1" /db_xref="EnsemblGenomes-Gn:BSU04430" /db_xref="EnsemblGenomes-Tr:CAB12250" /db_xref="GOA:P80878" /db_xref="InterPro:IPR007760" /db_xref="InterPro:IPR009078" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR027407" /db_xref="SubtiList:BG12071" /db_xref="UniProtKB/Swiss-Prot:P80878" /translation="MFKHTKMLQHPAKPDRPDPLFAKKMQEILGGQFGEISVAMQYLF QGWNTRGNEKYKDLLMDTATEELGHVEMIATMIARLLEDAPLDQQEKAAEDPVIGSIL GGMNPHHAIVSGLGAMPESSTGVPWSGGYIVASGNLLADFRANLNAESQGRLQVARLF EMTDDKGVKDMLSFLLARDTMHQNQWLAAIKELEAQEGPVVPGTFPKALEKQEFSHQL INFSEGEVSAEQNWLNEKAPDGEAFEYVKEAKTFGEKPELKPAPPFVHNTLPGRE*" /label="ydbD CDS" gene complement(477307..478128) /gene="ydbD" /locus_tag="BSU_04430" /old_locus_tag="BSU04430" /label="ydbD gene" downshifts complement(477311) /Source="Nicolas_upshifts" /id="D210" /incds=0 /nref=62 /ntot=214 /MaxReadThrough="4.23505" /MaxDrop="6.82771" /score="-6.55917314" /energy="-13.1" /TU="U348" /idTUdmin="U348" /TUdmin="-310" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(478150..478168) /Source="Nicolas_upshift_promotors" /id="U348" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=193 /SigmaFactorBS="gctgcgaaaagattcatagttcccatctcgatacgctgtttt tCGTTTATctttctatcgatcGGAAATATAAAAAGAGATAaacgaaaaaggagatggg t" /listShort="ydbD, S148" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(478171) /Source="Nicolas_upshifts" /id="U348" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=193 /SigmaFactorBS="gctgcgaaaagattcatagttcccatctcgatacgctgtttt tCGTTTATctttctatcgatcGGAAATATAAAAAGAGATAaacgaaaaaggagatggg t" /listShort="ydbD, S148" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(478182..478188) /Source="Nicolas_upshift_promotors" /id="U348" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=193 /SigmaFactorBS="gctgcgaaaagattcatagttcccatctcgatacgctgtttt tCGTTTATctttctatcgatcGGAAATATAAAAAGAGATAaacgaaaaaggagatggg t" /listShort="ydbD, S148" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(478213..479265) /gene="dctB" /locus_tag="BSU_04440" /old_locus_tag="BSU04440" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:1809844, 10708364, 11566984, 24375102" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1809844, 10708364, 11566984, 24375102; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="membrane bound C4-dicarboxylate binding sensor protein" /protein_id="NP_388325.1" /db_xref="EnsemblGenomes-Gn:BSU04440" /db_xref="EnsemblGenomes-Tr:CAB12251" /db_xref="GOA:P96600" /db_xref="InterPro:IPR004682" /db_xref="InterPro:IPR018389" /db_xref="SubtiList:BG12072" /db_xref="UniProtKB/Swiss-Prot:P96600" /translation="MKSLLACLALMIAGIATALFIGFHDHTGNKKIVYDDDQEGLQDQ IVFKFSHVVAENTPKGLAANKFADLVNEKSGGKIKIEVFPNGSLYSDIEEIEALQNGD VQFIAPSTSKLGMLSPEWGVLDLPYAFTDYNAVKKGLNGSIGTQLFDSLKKNQLKGLA YWTNGFKQITTNQGPVKTPDDLKGQDLRIMQSDVIEDQFKLLGATPHQESFNSTFQLL ENNVVDGEENTISNIYSKKFYNVQDYLTISSHGYLGYAVMTDEHFWKAQTPETRRILT EAMKETTEWNETYAEQMNKEQLEEIKKNSAIHIYELSDKEKQEWMKRLDPVYRQYEPI FGRELIRELLELRKDS*" /label="dctB CDS" gene complement(478213..479265) /gene="dctB" /locus_tag="BSU_04440" /old_locus_tag="BSU04440" /label="dctB gene" promotor_-35 478525..478532 /Source="Nicolas_upshift_promotors" /id="U349" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.882117882117882" /psig=1 /xcortree=1811 /SigmaFactorBS="cagtcatgacagcgtagccgagataaccgtggctgctTATTG TCAaatagtcctgaacaTTATAAAATTTTTTAGAATAgatgtttgaaattgtattttc t" /listShort="S149, dctS" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 478547..479334 /Source="Nicolas_S_feature" /locus_tag="new_496980_497767" /HighExp="LBGstat, Diami, T-0.40H, T0.0H, T0.30H, Heat, UNK1, GM-0.1, MG 90, Fru" /AntisenseName="dctB" /AntisenseCor="0.64205060306327899" /AntisenseRegPval="-31.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S149" promotor_-10 478547..478566 /Source="Nicolas_upshift_promotors" /id="U349" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.882117882117882" /psig=1 /xcortree=1811 /SigmaFactorBS="cagtcatgacagcgtagccgagataaccgtggctgctTATTG TCAaatagtcctgaacaTTATAAAATTTTTTAGAATAgatgtttgaaattgtattttc t" /listShort="S149, dctS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 478548 /Source="Nicolas_upshifts" /id="U349" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.882117882117882" /psig=1 /xcortree=1811 /SigmaFactorBS="cagtcatgacagcgtagccgagataaccgtggctgctTATTG TCAaatagtcctgaacaTTATAAAATTTTTTAGAATAgatgtttgaaattgtattttc t" /listShort="S149, dctS" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(479278..479297) /Source="Nicolas_upshift_promotors" /id="U350" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig="0.937062937062937" /xcortree=1551 /SigmaFactorBS="tttgttcatcagcttctcctttcagGTCTTTACgaatgtcat agccCCCATTATCCTTAACATAGGggagggcttttcatgaagagtttgcttgcatgtc t" /listShort="dctB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(479283) /Source="Nicolas_upshifts" /id="U350" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig="0.937062937062937" /xcortree=1551 /SigmaFactorBS="tttgttcatcagcttctcctttcagGTCTTTACgaatgtcat agccCCCATTATCCTTAACATAGGggagggcttttcatgaagagtttgcttgcatgtc t" /listShort="dctB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(479311..479318) /Source="Nicolas_upshift_promotors" /id="U350" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig="0.937062937062937" /xcortree=1551 /SigmaFactorBS="tttgttcatcagcttctcctttcagGTCTTTACgaatgtcat agccCCCATTATCCTTAACATAGGggagggcttttcatgaagagtttgcttgcatgtc t" /listShort="dctB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 479335..480942 /gene="dctS" /locus_tag="BSU_04450" /old_locus_tag="BSU04450" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:10627041, 11717295, 1290636, 12949159, 24375102" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10627041, 11717295, 1290636, 12949159, 24375102; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase" /protein_id="NP_388326.1" /db_xref="EnsemblGenomes-Gn:BSU04450" /db_xref="EnsemblGenomes-Tr:CAB12252" /db_xref="GOA:P96601" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR016120" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033463" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12073" /db_xref="UniProtKB/Swiss-Prot:P96601" /translation="MNKKKLSIRWKITILSYILVIFSFLIGGIVLIGNIQHTEERELK KRLMNTARTVSEMTEVKEALARKKQTEAVRHAVEEIRMINEADYIVVMDMNHIRYTHP VSTSIGKKSEGADEEAAFAEHIYFSEAKGEIGTAVRAFYPVKDQDLNQIGVVLVGKTL PGIADILLHLKRDIAFIVVLTLGFGLAGSFLLARHIKKQMFQLEPHEIVRMYEERTAT FHSMNEGVIAIDNRLVITIFNEKAKQIFEVQGDLIGKVIWEVLKDSRLPEIVERNKAV YNEEIRVSGKVIMSSRIPIVMKKKVIGAVAIFQDRTEAAKMAEELTGVRNFVEALRVQ NHEHMNKLHTIAGLIQLGKSEKALQLAFQASTEQENVTEFLHRSIQNDAAAGLLLSKI RRGRELGIAVHIDENSSLQQFPEHVDQHDIVVLLGNLIENAFGSFETVQSEDKRIDIS IEQTDDILAILIEDNGCGIEPTHMPRLYDKGFTVNKTGGTGYGLYLVKQIIDKGSGTI EVDSHAGQGTSFSIVFPMKGEEAQHGS*" /label="dctS CDS" gene 479335..480942 /gene="dctS" /locus_tag="BSU_04450" /old_locus_tag="BSU04450" /label="dctS gene" CDS 480932..481612 /gene="dctR" /locus_tag="BSU_04460" /old_locus_tag="BSU04460" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10627041, 11717295, 1290636, 12949159" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10627041, 11717295, 1290636, 12949159; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator" /protein_id="NP_388327.1" /db_xref="EnsemblGenomes-Gn:BSU04460" /db_xref="EnsemblGenomes-Tr:CAB12253" /db_xref="GOA:P96602" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR024187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12074" /db_xref="UniProtKB/Swiss-Prot:P96602" /translation="MARKEWKVLLIEDDPMVQEVNKDFITTVKGVTVCATAGNGEEGM KLIKEEQPDLVILDVYMPKKDGIKTLQEIRKQKLEVDVIVVSAAKDKETISLMLQNGA VDYILKPFKLERMRQALEKYKQYKQKIEANDTLSQEQLDAILNIPQQAVQDLPKGLNH FTMNEVTAFLKQQTASLSAEEVAKALGIARVTARRYLDYLEKTGIIKLDVQYGGVGRP VNRYVLKG*" /label="dctR CDS" gene 480932..481612 /gene="dctR" /locus_tag="BSU_04460" /old_locus_tag="BSU04460" /label="dctR gene" S_feature 481613..481687 /Source="Nicolas_S_feature" /locus_tag="new_500046_500120" /HighExp="Sw, Diami, Mt0, G150, BI, Lbstat, M40t45, Lbtran, Mal, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S150" promotor_-35 481654..481661 /Source="Nicolas_upshift_promotors" /id="U351" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.450549450549451" /psig="0.96003996003996" /xcortree=1558 /SigmaFactorBS="accaaaatgtccgttatgatcataaACTTCCCCagactgtat gaaaaCGCTATCATTCTAGTAAGaaagacacaaaaggcgaataggacagggggatgaa g" /listShort="dctP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 481676..481693 /Source="Nicolas_upshift_promotors" /id="U351" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.450549450549451" /psig="0.96003996003996" /xcortree=1558 /SigmaFactorBS="accaaaatgtccgttatgatcataaACTTCCCCagactgtat gaaaaCGCTATCATTCTAGTAAGaaagacacaaaaggcgaataggacagggggatgaa g" /listShort="dctP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 481689 /Source="Nicolas_upshifts" /id="U351" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.450549450549451" /psig="0.96003996003996" /xcortree=1558 /SigmaFactorBS="accaaaatgtccgttatgatcataaACTTCCCCagactgtat gaaaaCGCTATCATTCTAGTAAGaaagacacaaaaggcgaataggacagggggatgaa g" /listShort="dctP" /GFF_Attribute="listLong" /label="upshifts" CDS 481733..482998 /gene="dctP" /locus_tag="BSU_04470" /old_locus_tag="BSU04470" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10627041, 10708364, 12949159, 15849754, 16850406, 20363944, 22389480" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10627041, 10708364, 12949159, 15849754, 16850406, 20363944, 22389480; Product type t: transporter" /codon_start=1 /transl_table=11 /product="C4-dicarboxylate transport protein" /protein_id="NP_388328.1" /db_xref="EnsemblGenomes-Gn:BSU04470" /db_xref="EnsemblGenomes-Tr:CAB12254" /db_xref="GOA:P96603" /db_xref="InterPro:IPR001991" /db_xref="InterPro:IPR018107" /db_xref="InterPro:IPR023954" /db_xref="InterPro:IPR036458" /db_xref="SubtiList:BG12075" /db_xref="UniProtKB/Swiss-Prot:P96603" /translation="MKLFKNLTVQVITAVIIGVIVGLVWPDVGKEMKPLGDTFINAVK MVIAPIIFFTIVLGIAKMGDMKKVGKVGGKAFIYFEVVTTLALIIGLFVVNIMKPGAG LDYSKLEKGDVSQYTQNGGQGIDWIEFITHIVPSNMVDAFAKGDILQVLFFSILFGVG LAALGEKGKSVIDFFDKVSHVFFKIIGYIMRAAPIGAFGAMAYTIGHFGLDSIKPLAS LMMSVYITMFLFVFVALNIICKLYGFSLWNYLRFIKDELLIVLGTSSSESVLPRMMDK MERYGCSKSVVGLVIPTGYSFNLDGTSIYLSMATVFLAQVFGVDLSIGQQITIILVLM LTSKGAAGVTGSGFIVLASTLSALQVIPLEGLALLLGVDRFMSEGRAIVNLIGNGIAT IIVAKSENEFDEAKSIEAVEGMKKMKTAV*" /label="dctP CDS" gene 481733..482998 /gene="dctP" /locus_tag="BSU_04470" /old_locus_tag="BSU04470" /label="dctP gene" downshifts 482991 /Source="Nicolas_upshifts" /id="D211" /incds=0 /nref=175 /ntot=235 /MaxReadThrough="3.99042" /MaxDrop="7.04798" /score="45.0636559" /energy="-12.6" /TU="NA" /idTUdmin="U351" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(483045) /Source="Nicolas_upshifts" /id="D212" /incds=0 /nref=1 /ntot=9 /MaxReadThrough="0.588190000000001" /MaxDrop="3.06255" /score="19.3433396" /energy="-12.6" /TU="NA" /idTUdmin="U350" /TUdmin="-4818" /isTUend="FALSE" /label="downshifts" misc_feature 483082..483099 /Source="Nicolas_upshift_promotors" /id="U352" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.423576423576424" /psig="0.483516483516484" /xcortree=1457 /SigmaFactorBS="gtttttttaattgtttaagaattattaaggtaaggacagaga cctcagcatttttttgTTATATAATTTACAAATGgatactatattgaatgaaggacgt t" /listShort="ydbI, S151, ydbJ, ydbK, ydbL, S152, ydbM" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 483084 /Source="Nicolas_upshifts" /id="U352" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.423576423576424" /psig="0.483516483516484" /xcortree=1457 /SigmaFactorBS="gtttttttaattgtttaagaattattaaggtaaggacagaga cctcagcatttttttgTTATATAATTTACAAATGgatactatattgaatgaaggacgt t" /listShort="ydbI, S151, ydbJ, ydbK, ydbL, S152, ydbM" /GFF_Attribute="listLong" /label="upshifts" CDS 483146..484198 /gene="ydbI" /locus_tag="BSU_04480" /old_locus_tag="BSU04480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388329.1" /db_xref="EnsemblGenomes-Gn:BSU04480" /db_xref="EnsemblGenomes-Tr:CAB12255" /db_xref="GOA:P96604" /db_xref="InterPro:IPR002549" /db_xref="SubtiList:BG12076" /db_xref="UniProtKB/Swiss-Prot:P96604" /translation="MAALVKFFQHPGVRRFSIFVVLTGVLYLFKSMINLILLTFIFTF LMDRLELVVRQFVSQFFRVSQRVVITFLYMLLAVLLTVGGFVFYPVVAAQIQQLVKQI KHIAYHPDSIPFFDEITSVFGDINISSYVKEGFNVVYTYLADISTFGLQVVMALILSM FFLFEKKRLSEFMAKFKTSKLRVFYEEIAFFGSKFARTFGKVLEAQFIIALVNCILTF IALWIMHFPQLFGLSIMVFFLGLIPVAGVVISLIPLSIIAYSTGGGMYVLYIVLVIFA IHAIETYFLNPKLMSAKTELPIFFTFTVLIFSEHFFGIWGLIIGIPIFVFLLDILDVT NKEDRSKGPRENSDKK*" /label="ydbI CDS" gene 483146..484198 /gene="ydbI" /locus_tag="BSU_04480" /old_locus_tag="BSU04480" /label="ydbI gene" S_feature 484199..484442 /Source="Nicolas_S_feature" /locus_tag="new_502632_502875" /HighExp="S8, S5, S6, LoTm, S7, S3, LBGstat, LBGexp, Paraq, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.87223499999999998" /TUshortSig="Sig-" /TUshortPSig="0.484" /TUlongSig="NA" /TUlongPSig="NA" /label="S151" downshifts 484399 /Source="Nicolas_upshifts" /id="D213" /incds=0 /nref=6 /ntot=45 /MaxReadThrough="6.05001" /MaxDrop="3.52626" /score="17.6400305" /energy="-12.4" /TU="U352" /idTUdmin="U351" /TUdmin=1408 /isTUend="FALSE" /label="downshifts" CDS 484475..485401 /gene="ydbJ" /locus_tag="BSU_04490" /old_locus_tag="BSU04490" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding subunit)" /protein_id="NP_388330.1" /db_xref="EnsemblGenomes-Gn:BSU04490" /db_xref="EnsemblGenomes-Tr:CAB12256" /db_xref="GOA:P96605" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12077" /db_xref="UniProtKB/Swiss-Prot:P96605" /translation="MAEPILHIEGLDKKIGSKQILKQISMDVMEGEIIGLLGPNGSGK TTLIRIIVGLLKQNSGSVTISGFQHDTEFEKAMEAVGAIVENPEFYPYLTGWENLKHF ANMHKKIADERLDEVVERVGLTSAIHDKVKTYSLGMRQRLGIAQAILHRPKLLILDEP TNGLDPAGMKDFRDHIKELAEMEGTAVLFATHLLREVEDLCDRVIIIQKGEIKAEVSL QGTDQTTEKAIIEVQPQEKALNWLTGNQYQAESQDGTIVVEVAKENIPELNRSLVGQD LNVFSITPYTQSLEDEFIKATTAHQEEGEELV*" /label="ydbJ CDS" gene 484475..485401 /gene="ydbJ" /locus_tag="BSU_04490" /old_locus_tag="BSU04490" /label="ydbJ gene" CDS 485421..486161 /gene="ydbK" /locus_tag="BSU_04500" /old_locus_tag="BSU04500" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12486040, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux ABC-transporter (permease subunit)" /protein_id="NP_388331.1" /db_xref="EnsemblGenomes-Gn:BSU04500" /db_xref="EnsemblGenomes-Tr:CAB12257" /db_xref="GOA:P96606" /db_xref="InterPro:IPR032688" /db_xref="SubtiList:BG12078" /db_xref="UniProtKB/Swiss-Prot:P96606" /translation="MKLFNRKVTLVSLILMAVFQFFMALIIKRIVISAGTDENFIGYL SYTPSLNILLQALTIVIAATIVSMEFDKKTIKFLLIRPVKRQKVFWSKLITVVMVSFY LYLAYYILALLFGLLFFGTSVTAESKTLLVNTLALIGSNWLEAVMMGLFGLLCSSLFR NSAVAVVVSFVVLYGASTLVQLMKLFENKWGSFLLFANTDFTQYRSGETALFSGMTPL FSIGILIIHAIFFIVVGWWCFCKRDVRV*" /label="ydbK CDS" gene 485421..486161 /gene="ydbK" /locus_tag="BSU_04500" /old_locus_tag="BSU04500" /label="ydbK gene" misc_feature 486220..486239 /Source="Nicolas_upshift_promotors" /id="U353" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.612387612387612" /psig="0.99000999000999" /xcortree=1624 /SigmaFactorBS="caaggaatgacatttttgtgaaaaagctcacgtaaatcaata tcatttgatatttTGGTTTATACTAAAGGTACTgacggaggtgtctcgattgaggaac t" /listShort="ydbL, S152, ydbM" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 486225 /Source="Nicolas_upshifts" /id="U353" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.612387612387612" /psig="0.99000999000999" /xcortree=1624 /SigmaFactorBS="caaggaatgacatttttgtgaaaaagctcacgtaaatcaata tcatttgatatttTGGTTTATACTAAAGGTACTgacggaggtgtctcgattgaggaac t" /listShort="ydbL, S152, ydbM" /GFF_Attribute="listLong" /label="upshifts" CDS 486256..486591 /gene="ydbL" /locus_tag="BSU_04510" /old_locus_tag="BSU04510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17928292; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative glyco-prenyl flippase subunit" /protein_id="NP_388332.1" /db_xref="EnsemblGenomes-Gn:BSU04510" /db_xref="EnsemblGenomes-Tr:CAB12258" /db_xref="GOA:P96607" /db_xref="SubtiList:BG12079" /db_xref="UniProtKB/Swiss-Prot:P96607" /translation="MRNFITALPIVLLLGFSFVSFMFQFEHLVYFRLALGLFSLVGLY MIYKMKTGIRYFIIYLYASWIVLAAVTAFEEPIFSSFFFGGLVMTMGYLTYMLIYLGM KQDRDANPV*" /label="ydbL CDS" gene 486256..486591 /gene="ydbL" /locus_tag="BSU_04510" /old_locus_tag="BSU04510" /label="ydbL gene" downshifts 486566 /Source="Nicolas_upshifts" /id="D214" /incds=0 /nref=2 /ntot=99 /MaxReadThrough="5.33473" /MaxDrop="5.39081" /score="25.8152101" /energy="-18.4" /TU="U352,U353" /idTUdmin="U352" /TUdmin="-1177" /isTUend="FALSE" /label="downshifts" S_feature 486611..486680 /Source="Nicolas_S_feature" /locus_tag="new_505044_505113" /HighExp="ferm, nit, S2, S0, Gly, M0t45, M0t90, Lbstat, M/G, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="0.99, 0.484" /TUlongSig="NA" /TUlongPSig="NA" /label="S152" promotor_-35 486646..486653 /Source="Nicolas_upshift_promotors" /id="U354" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.572427572427572" /psig="0.973026973026973" /xcortree=1741 /SigmaFactorBS="ttttctatactgggcaaaaggttaaCAGTTGCGgaaaaatgg caggAAATCTATAATACATATTAAatttatcggaattaaaactggggggctgccggat g" /listShort="ydbM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 486667..486686 /Source="Nicolas_upshift_promotors" /id="U354" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.572427572427572" /psig="0.973026973026973" /xcortree=1741 /SigmaFactorBS="ttttctatactgggcaaaaggttaaCAGTTGCGgaaaaatgg caggAAATCTATAATACATATTAAatttatcggaattaaaactggggggctgccggat g" /listShort="ydbM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 486681 /Source="Nicolas_upshifts" /id="U354" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.572427572427572" /psig="0.973026973026973" /xcortree=1741 /SigmaFactorBS="ttttctatactgggcaaaaggttaaCAGTTGCGgaaaaatgg caggAAATCTATAATACATATTAAatttatcggaattaaaactggggggctgccggat g" /listShort="ydbM" /GFF_Attribute="listLong" /label="upshifts" CDS 486719..487864 /gene="ydbM" /locus_tag="BSU_04520" /old_locus_tag="BSU04520" /EC_number="1.3.99.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12193636, 16513748, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyl-CoA dehydrogenase" /protein_id="NP_388333.1" /db_xref="EnsemblGenomes-Gn:BSU04520" /db_xref="EnsemblGenomes-Tr:CAB12259" /db_xref="GOA:P96608" /db_xref="InterPro:IPR006091" /db_xref="InterPro:IPR009100" /db_xref="InterPro:IPR013107" /db_xref="InterPro:IPR013786" /db_xref="InterPro:IPR036250" /db_xref="InterPro:IPR037069" /db_xref="SubtiList:BG12080" /db_xref="UniProtKB/Swiss-Prot:P96608" /translation="MSLFIQNDQQRQWMEKIGRIADEFQQTAAEDDEQGRFPAEKIQK LRDAGYTALTLPASHGGGGISVYDMLLFQERLARGDAPTALSIGWHLSVIGELGEGNS WDEDVFAFVAKEVQNGAVINRAATEAKTGSPTRGGRPGTHAVKKDGKWAVNGRKTFTT MSQALDYFLVTAWIEDKQTTGVFLIHKDDPGLSIEETWDMMAMRATGSHDLVLNEVML DENKLVELLQGPRGAKPNGWLLHIPAIYLGVAQAARDYAVQFASEYSPNSLNGPIKNV PAVQQRTGEMELELLNARHFLFHIAQLYDDPVRRPHLTSELGAAKHIVTNAALSVVDK AMRIVGAKSLERTNPLQRYYRDVRAGLHNPPMDDAVIHKLAAEAFES*" /label="ydbM CDS" gene 486719..487864 /gene="ydbM" /locus_tag="BSU_04520" /old_locus_tag="BSU04520" /label="ydbM gene" downshifts 487846 /Source="Nicolas_upshifts" /id="D215" /incds=0 /nref=13 /ntot=123 /MaxReadThrough="2.90782" /MaxDrop="4.20573" /score="9.48525091" /energy="-7" /TU="NA" /idTUdmin="U353" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(487889..488068) /gene="fbpB" /locus_tag="BSU_04530" /old_locus_tag="BSU04530" /experiment="publication(s) with functional evidences, PMID:12354229, 16428414, 18697947, 22427629" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 16428414, 18697947, 22427629; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of iron homeostasis" /protein_id="NP_388334.1" /db_xref="EnsemblGenomes-Gn:BSU04530" /db_xref="EnsemblGenomes-Tr:CAB12260" /db_xref="GOA:P96609" /db_xref="InterPro:IPR025004" /db_xref="SubtiList:BG12081" /db_xref="UniProtKB/Swiss-Prot:P96609" /translation="MNTNMSGGRRSMPKRKVKTYQQLIQENKEAIMGNPKLMNVIYDR IDRKHQKNLQEQNNT*" /label="fbpB CDS" gene complement(487889..488068) /gene="fbpB" /locus_tag="BSU_04530" /old_locus_tag="BSU04530" /label="fbpB gene" downshifts complement(487907) /Source="Nicolas_upshifts" /id="D216" /incds=0 /nref=158 /ntot=207 /MaxReadThrough="2.35872" /MaxDrop="6.38199" /score="26.3317207" /energy="-7" /TU="NA" /idTUdmin="U355" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(488022..488186) /gene="fbpA" /locus_tag="BSU_04536" /old_locus_tag="BSU04536" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18697947" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18697947; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of iron homeostasis" /protein_id="YP_009513944.1" /db_xref="EnsemblGenomes-Gn:BSU04536" /db_xref="EnsemblGenomes-Tr:CCQ48594" /db_xref="InterPro:IPR025072" /db_xref="UniProtKB/TrEMBL:L8ECQ9" /translation="MTPQSAEIRKKQLIHLLIQNGIYKKSKRHLYELSLTELESEYKH VRRAPEHAEA*" /label="fbpA CDS" gene complement(488022..488186) /gene="fbpA" /locus_tag="BSU_04536" /old_locus_tag="BSU04536" /label="fbpA gene" S_feature complement(488069..488237) /Source="Nicolas_S_feature" /locus_tag="new_506502_506670_c" /HighExp="B60, nit, B36, Lbexp, GM 15, GM 10, dia0, S2, GM 25, BI" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99141199999999996" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S153" promotor_-10 complement(488229..488248) /Source="Nicolas_upshift_promotors" /id="U355" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2111 /SigmaFactorBS="taaattggccaagaataggactcttttcaTCTTTACAggcta ttgcggacaTTGTATACTGAAGTTAATTGataatgattatcaatatcgtttgattgga g" /listShort="S153, ydbN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(488239) /Source="Nicolas_upshifts" /id="U355" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2111 /SigmaFactorBS="taaattggccaagaataggactcttttcaTCTTTACAggcta ttgcggacaTTGTATACTGAAGTTAATTGataatgattatcaatatcgtttgattgga g" /listShort="S153, ydbN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(488263..488270) /Source="Nicolas_upshift_promotors" /id="U355" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2111 /SigmaFactorBS="taaattggccaagaataggactcttttcaTCTTTACAggcta ttgcggacaTTGTATACTGAAGTTAATTGataatgattatcaatatcgtttgattgga g" /listShort="S153, ydbN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 488378..488383 /Source="Nicolas_upshift_promotors" /id="U356" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.933066933066933" /psig="0.933066933066933" /xcortree=1191 /SigmaFactorBS="tgctgtcgaaatattccgcttcattgaacgcacccTGCTATt tttcatgttttgaaCCATACTATGTAATAGAATggaggctggtattcaatggagcgga c" /listShort="ydbO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 488399..488417 /Source="Nicolas_upshift_promotors" /id="U356" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.933066933066933" /psig="0.933066933066933" /xcortree=1191 /SigmaFactorBS="tgctgtcgaaatattccgcttcattgaacgcacccTGCTATt tttcatgttttgaaCCATACTATGTAATAGAATggaggctggtattcaatggagcgga c" /listShort="ydbO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 488403 /Source="Nicolas_upshifts" /id="U356" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.933066933066933" /psig="0.933066933066933" /xcortree=1191 /SigmaFactorBS="tgctgtcgaaatattccgcttcattgaacgcacccTGCTATt tttcatgttttgaaCCATACTATGTAATAGAATggaggctggtattcaatggagcgga c" /listShort="ydbO" /GFF_Attribute="listLong" /label="upshifts" CDS 488433..489305 /gene="ydbO" /locus_tag="BSU_04540" /old_locus_tag="BSU04540" /function="16.8: Protect" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative cation efflux system" /protein_id="NP_388335.1" /db_xref="EnsemblGenomes-Gn:BSU04540" /db_xref="EnsemblGenomes-Tr:CAB12261" /db_xref="GOA:P96610" /db_xref="InterPro:IPR002524" /db_xref="InterPro:IPR027469" /db_xref="InterPro:IPR027470" /db_xref="InterPro:IPR036837" /db_xref="SubtiList:BG12082" /db_xref="UniProtKB/Swiss-Prot:P96610" /translation="MERTENLKKGEKGALLNIFAYVILAVVKLVIGILYHSEALRADG LNNGTDIVASVAVLIGLRISQRPADSDHPYGHYRAETISSLVASFIMMAVGIEVLIGG GKAIAGGTTETPNLIAAWTALGSAVFMYGIYLYNKRLAASIKSSALMAAAKDSRSDAF VSAGAFIGVFSSQLKLPWVDPVTAFIIGIIICKTAWDIFKDASHSLTDGFHLKDLEPY KQTVGRIENVHRLKDVKARYLGSTVHIEMVITVDPKLTVEEGHGVADEVEDKIKHEHD VTHVHVHVEPDDIK*" /label="ydbO CDS" gene 488433..489305 /gene="ydbO" /locus_tag="BSU_04540" /old_locus_tag="BSU04540" /label="ydbO gene" promotor_-35 488669..488678 /Source="Nicolas_upshift_promotors" /id="U357" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1650 /SigmaFactorBS="gctgacagcgatcatccatacggccattatcgggcTGAAACA ATTtcgtctcttgttGCGTCTTTTATTATGAtggcagtcggcattgaagtgttaatcg g" /listShort="S155, S156, ddl, murF, S157, S158, cshA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 488691..488706 /Source="Nicolas_upshift_promotors" /id="U357" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1650 /SigmaFactorBS="gctgacagcgatcatccatacggccattatcgggcTGAAACA ATTtcgtctcttgttGCGTCTTTTATTATGAtggcagtcggcattgaagtgttaatcg g" /listShort="S155, S156, ddl, murF, S157, S158, cshA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 488694 /Source="Nicolas_upshifts" /id="U357" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1650 /SigmaFactorBS="gctgacagcgatcatccatacggccattatcgggcTGAAACA ATTtcgtctcttgttGCGTCTTTTATTATGAtggcagtcggcattgaagtgttaatcg g" /listShort="S155, S156, ddl, murF, S157, S158, cshA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(489250..489319) /Source="Nicolas_S_feature" /locus_tag="new_507683_507752_c" /HighExp="LPhT, dia15, dia5, Diami, Etha, Lbtran, LBGtran, LBGstat, Mt0, M0t45" /AntisenseName="ydbO" /AntisenseCor="0.18463882527998399" /AntisenseRegPval="-2.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S154" downshifts complement(489293) /Source="Nicolas_upshifts" /id="D217" /incds=0 /nref=145 /ntot=242 /MaxReadThrough="3.07579" /MaxDrop="6.00116" /score="9.69023537" /energy="-12.3" /TU="U359" /idTUdmin="U359" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" S_feature 489306..489655 /Source="Nicolas_S_feature" /locus_tag="new_507739_508088" /HighExp="Salt, Paraq, G135, ferm, Oxctl, T-0.40H, G150, Lbexp, T3.0H, T2.30H" /AntisenseName="ydbP" /AntisenseCor="-0.27800721625230801" /AntisenseRegPval="-5.4" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S155" CDS complement(489320..489640) /gene="ydbP" /locus_tag="BSU_04550" /old_locus_tag="BSU04550" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10482513; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thioredoxin or thiol-disulfide isomerase" /protein_id="NP_388336.1" /db_xref="EnsemblGenomes-Gn:BSU04550" /db_xref="EnsemblGenomes-Tr:CAB12262" /db_xref="GOA:P96611" /db_xref="InterPro:IPR005746" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG12083" /db_xref="UniProtKB/Swiss-Prot:P96611" /translation="MKKITTNEQFNELIQSDKEIIVKFYADWCPDCTRMNMFIGDILE EYNQNDWYELNKDELPDLAEKYQVMGIPSLLIFKNGEKTAHLHSANAKTPEEVTEFLS EHIS*" /label="ydbP CDS" gene complement(489320..489640) /gene="ydbP" /locus_tag="BSU_04550" /old_locus_tag="BSU04550" /label="ydbP gene" promotor_-35 489636..489640 /Source="Nicolas_upshift_promotors" /id="U358" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.65034965034965" /psig="0.298701298701299" /xcortree=1554 /SigmaFactorBS="tgaatcagttcattaaattgttcgtttgttgtgatttttTTC ATatgtcacaTCTCCTTTTCAATGCcattttaatataaaataaaaaggaattacatac a" /listShort="S156, ddl, murF, S157, S158, cshA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 489649..489663 /Source="Nicolas_upshift_promotors" /id="U358" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.65034965034965" /psig="0.298701298701299" /xcortree=1554 /SigmaFactorBS="tgaatcagttcattaaattgttcgtttgttgtgatttttTTC ATatgtcacaTCTCCTTTTCAATGCcattttaatataaaataaaaaggaattacatac a" /listShort="S156, ddl, murF, S157, S158, cshA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 489657..489814 /Source="Nicolas_S_feature" /locus_tag="new_508090_508247" /HighExp="Lbexp, dia0, LBGexp, H2O2, Paraq, Oxctl, G180, Salt, M0t45, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigWXY" /TUshortPSig="0.299, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S156" upshifts 489657 /Source="Nicolas_upshifts" /id="U358" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.65034965034965" /psig="0.298701298701299" /xcortree=1554 /SigmaFactorBS="tgaatcagttcattaaattgttcgtttgttgtgatttttTTC ATatgtcacaTCTCCTTTTCAATGCcattttaatataaaataaaaaggaattacatac a" /listShort="S156, ddl, murF, S157, S158, cshA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(489661..489680) /Source="Nicolas_upshift_promotors" /id="U359" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=2021 /SigmaFactorBS="gatctaattatttttgggcatgctgatgttgaatgCATTTGT AtgtaattccttttTATTTTATATTAAAATGGCAttgaaaaggagatgtgacatatga a" /listShort="ydbP, S154" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(489676) /Source="Nicolas_upshifts" /id="U359" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=2021 /SigmaFactorBS="gatctaattatttttgggcatgctgatgttgaatgCATTTGT AtgtaattccttttTATTTTATATTAAAATGGCAttgaaaaggagatgtgacatatga a" /listShort="ydbP, S154" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(489694..489701) /Source="Nicolas_upshift_promotors" /id="U359" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=2021 /SigmaFactorBS="gatctaattatttttgggcatgctgatgttgaatgCATTTGT AtgtaattccttttTATTTTATATTAAAATGGCAttgaaaaggagatgtgacatatga a" /listShort="ydbP, S154" /GFF_Attribute="listLong" /label="promotor_-35" CDS 489815..490879 /gene="ddlA" /locus_tag="BSU_04560" /old_locus_tag="BSU04560" /EC_number="6.3.2.4" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8662022, 12682299, 22407814; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanyl-D-alanine ligase A" /protein_id="NP_388337.1" /db_xref="EnsemblGenomes-Gn:BSU04560" /db_xref="EnsemblGenomes-Tr:CAB12263" /db_xref="GOA:P96612" /db_xref="InterPro:IPR000291" /db_xref="InterPro:IPR005905" /db_xref="InterPro:IPR011095" /db_xref="InterPro:IPR011127" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="SubtiList:BG11932" /db_xref="UniProtKB/Swiss-Prot:P96612" /translation="MYGGKSAEHNVSLQTALAVIKALNTEKFDIHPIYITEKGEWVRG ARLTEPVSNVKMLQFEQGGSAFSPAALNQEMFPQEASQQNEAIDVVFPLLHGPNGEDG TIQGMLELLNIPYVGNGVLASSAGMDKVVMKHLFAQVGLAQAKYAAFLKKDWTRSPKE SCEEVEQELGYPCFVKPANLGSSVGISKCRNREELQKAFELAFQYDRKVVVEEGINGR EIEIGVLGNDDPKCSVVGEIAPKTDFYDYKAKYEDGDTDLMIPAIVTDEEYATISDMA IKAFKAIDGSGLVRADFFLTADGEVLINEVNTMPGFTPFSMFPLLWKEAGVEYADLIE QLVELAKERHAEKQLIKHTF*" /label="ddlA CDS" gene 489815..490879 /gene="ddlA" /locus_tag="BSU_04560" /old_locus_tag="BSU04560" /label="ddlA gene" downshifts 490867 /Source="Nicolas_upshifts" /id="D218" /incds=0 /nref=1 /ntot=59 /MaxReadThrough="5.68418" /MaxDrop="2.53103" /score="3.92144467" /energy="-9.6" /TU="U357,U358" /idTUdmin="U356" /TUdmin=2310 /isTUend="FALSE" /label="downshifts" CDS 490951..492324 /gene="murF" /locus_tag="BSU_04570" /old_locus_tag="BSU04570" /EC_number="6.3.2.10" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 17714441; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate-D-alanyl-D-alanine ligase" /protein_id="NP_388338.1" /db_xref="EnsemblGenomes-Gn:BSU04570" /db_xref="EnsemblGenomes-Tr:CAB12264" /db_xref="GOA:P96613" /db_xref="InterPro:IPR000713" /db_xref="InterPro:IPR004101" /db_xref="InterPro:IPR005863" /db_xref="InterPro:IPR013221" /db_xref="InterPro:IPR035911" /db_xref="InterPro:IPR036565" /db_xref="InterPro:IPR036615" /db_xref="SubtiList:BG12084" /db_xref="UniProtKB/Swiss-Prot:P96613" /translation="MIKRTVKNIAEMVKGTLANPQYEQTVIHGVATDTRKLEQHQLFI PLKGERFDGHSFVEQAFEAGVAAVLWDRSVPNPPENHAVILVDDTLTALQQLAKAYLQ ELGTRVIGVTGSNGKTTTKDMIHAVLGTQYRVHKTGGNFNNHIGLPLTVLAMPENTEI AVLEMGMSAKGEIDLLSRLANPDAAVITNIGESHMQDLGSREGIAEAKLEIINGLKED GVLIYIGDEPLLQNAYSCQTKTYGTGTHNDYQLQDVSQSEEGTHFTIKGIENTFFIPI LGKHNVMNAMAAIAAGAYFGIAPEDAAKGLSGLKVTGMRLELIKTDSGLSIINDAYNA SPTSMKAAIQLTESLEGYGKKMLVLGDMLELGDLEETFHKECGAVISPDKIDRVFTYG KLGAFIAEGALKHFEKDRVSHYTEKKDLLQAVKENASKGDLILFKASRGMKLEEIVKD LIESPLS*" /label="murF CDS" gene 490951..492324 /gene="murF" /locus_tag="BSU_04570" /old_locus_tag="BSU04570" /label="murF gene" promotor_-35 492355..492361 /Source="Nicolas_upshift_promotors" /id="U360" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=849 /SigmaFactorBS="gaaaatattttgcgaaaaaacgcatattgcATCATAAaataa cctgatatGCAAACACTAATgtatgccggccgaaaattatgtatatctggccggctgc g" /listShort="S157, S158, cshA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 492375..492386 /Source="Nicolas_upshift_promotors" /id="U360" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=849 /SigmaFactorBS="gaaaatattttgcgaaaaaacgcatattgcATCATAAaataa cctgatatGCAAACACTAATgtatgccggccgaaaattatgtatatctggccggctgc g" /listShort="S157, S158, cshA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 492385 /Source="Nicolas_upshifts" /id="U360" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=849 /SigmaFactorBS="gaaaatattttgcgaaaaaacgcatattgcATCATAAaataa cctgatatGCAAACACTAATgtatgccggccgaaaattatgtatatctggccggctgc g" /listShort="S157, S158, cshA" /GFF_Attribute="listLong" /label="upshifts" misc_feature 492428..492447 /Source="Nicolas_upshift_promotors" /id="U361" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.958041958041958" /psig=1 /xcortree=2138 /SigmaFactorBS="tgatatgcaaacactaatgtatgccggccgaaaattatgtat atctggccggctgcggcTATGATACAATATATATAGGttatttcgcgatacgaacata t" /listShort="S157, S158, cshA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 492429..492603 /Source="Nicolas_S_feature" /locus_tag="new_510862_511036" /HighExp="Cold, ferm, nit, G135, S5, LBGexp, G150, S8, S7, BI" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.76694499999999999" /TUshortSig="SigA, SigGF, Sig-, SigWXY" /TUshortPSig="1, 1, 0.299, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S157" upshifts 492429 /Source="Nicolas_upshifts" /id="U361" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.958041958041958" /psig=1 /xcortree=2138 /SigmaFactorBS="tgatatgcaaacactaatgtatgccggccgaaaattatgtat atctggccggctgcggcTATGATACAATATATATAGGttatttcgcgatacgaacata t" /listShort="S157, S158, cshA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 492571..492578 /Source="Nicolas_upshift_promotors" /id="U362" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=1884 /SigmaFactorBS="tcgagatgccgatctgcttctcatctTATTGAAAaacaaata gtgtaaTGGTAAGATAAAACTTAAAGtaattcgggctttgtatacggatggatcctgt c" /listShort="S158, cshA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 492593..492612 /Source="Nicolas_upshift_promotors" /id="U362" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=1884 /SigmaFactorBS="tcgagatgccgatctgcttctcatctTATTGAAAaacaaata gtgtaaTGGTAAGATAAAACTTAAAGtaattcgggctttgtatacggatggatcctgt c" /listShort="S158, cshA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 492605..492672 /Source="Nicolas_S_feature" /locus_tag="new_511038_511105" /HighExp="Cold, G150, T-3.40H, HPh, Salt, LPh, G180, G135, Oxctl, T-5.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigGF, Sig-, SigWXY" /TUshortPSig="1, 1, 1, 0.299, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S158" upshifts 492605 /Source="Nicolas_upshifts" /id="U362" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=1884 /SigmaFactorBS="tcgagatgccgatctgcttctcatctTATTGAAAaacaaata gtgtaaTGGTAAGATAAAACTTAAAGtaattcgggctttgtatacggatggatcctgt c" /listShort="S158, cshA" /GFF_Attribute="listLong" /label="upshifts" CDS 492724..494208 /gene="cshA" /locus_tag="BSU_04580" /old_locus_tag="BSU04580" /EC_number="3.6.1.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16352840, 27965645" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16352840, 27965645; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent RNA helicase; cold shock" /protein_id="NP_388339.2" /db_xref="EnsemblGenomes-Gn:BSU04580" /db_xref="EnsemblGenomes-Tr:CAB12265" /db_xref="GOA:P96614" /db_xref="InterPro:IPR000629" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR014014" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030880" /db_xref="SubtiList:BG12085" /db_xref="UniProtKB/Swiss-Prot:P96614" /translation="MTITFQDFNLSSDLMKAINRMGFEEATPIQAQTIPLGLSNKDVI GQAQTGTGKTAAFGIPLVEKINPESPNIQAIVIAPTRELAIQVSEELYKIGQDKRAKV LPIYGGQDIGRQIRALKKNPNIIVGTPGRLLDHINRRTIRLNNVNTVVMDEADEMLNM GFIDDIESILSNVPSEHQTLLFSATMPAPIKRIAERFMTEPEHVKVKAKEMTVSNIQQ FYLEVQERKKFDTLTRLLDIQSPELAIVFGRTKRRVDELAEALNLRGYAAEGIHGDLT QAKRMVALRKFKEGAIEVLVATDVAARGLDISGVTHVYNFDVPQDPESYVHRIGRTGR AGKTGMAMTFITPREKSMLRAIEQTTKRKMDRMKEPTLDEALEGQQQVTVERLRTTIS ENNLNFYMTAAAELLEDHDAVTVVAAAIKMATKEPDDTPVRLTDEAPMVSKRYKNQRS SKRRDGQGGGYRGGKGKSNNRSSYDKKRSNDRRSSGDRRQKKSY*" /label="cshA CDS" gene 492724..494208 /gene="cshA" /locus_tag="BSU_04580" /old_locus_tag="BSU04580" /label="cshA gene" downshifts 494201 /Source="Nicolas_upshifts" /id="D219" /incds=0 /nref=309 /ntot=313 /MaxReadThrough="1.91428" /MaxDrop="8.13079" /score="26.104757" /energy="-13.1" /TU="NA" /idTUdmin="U358" /TUdmin="-10" /isTUend="TRUE" /label="downshifts" S_feature 494321..494380 /Source="Nicolas_S_feature" /locus_tag="new_512754_512813" /HighExp="Etha, LBGexp, G180, Cold, Lbtran, dia0, G150, BMM, UNK1, MG-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S159" promotor_-35 494321..494330 /Source="Nicolas_upshift_promotors" /id="U363" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1673 /SigmaFactorBS="tttgttattcagcaaactttcagctgacggaagccatttttc tctgtatgcttaagaaTGAAACCTTTctgtaaaagagACGTATAAATAACGACgaaaa a" /listShort="S159, ydbS, ydbT, S160, S161, acpS, S162, ydcC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 494323 /Source="Nicolas_upshifts" /id="U363" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1673 /SigmaFactorBS="tttgttattcagcaaactttcagctgacggaagccatttttc tctgtatgcttaagaaTGAAACCTTTctgtaaaagagACGTATAAATAACGACgaaaa a" /listShort="S159, ydbS, ydbT, S160, S161, acpS, S162, ydcC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 494342..494357 /Source="Nicolas_upshift_promotors" /id="U363" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1673 /SigmaFactorBS="tttgttattcagcaaactttcagctgacggaagccatttttc tctgtatgcttaagaaTGAAACCTTTctgtaaaagagACGTATAAATAACGACgaaaa a" /listShort="S159, ydbS, ydbT, S160, S161, acpS, S162, ydcC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 494381..494860 /gene="ydbS" /locus_tag="BSU_04590" /old_locus_tag="BSU04590" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16629676" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16629676; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="resistance to heterologous antibiotics" /protein_id="NP_388340.1" /db_xref="EnsemblGenomes-Gn:BSU04590" /db_xref="EnsemblGenomes-Tr:CAB12266" /db_xref="GOA:P96615" /db_xref="InterPro:IPR005182" /db_xref="SubtiList:BG12086" /db_xref="UniProtKB/Swiss-Prot:P96615" /translation="MREQPKNQISPDGLKVWRLQEIIISAVCLLIVIAVAVLSYYFHW PYWISGVLGAVWLLGSIVTVFIIPKVRHKVWRYEVHEHEIDIQSGIFVVTRVIVPMVR VQHVDTSQGPLLKKYNLATVKISTAATVHSIPALEMEEADRLRDSISRLARVTDDDV* " /label="ydbS CDS" gene 494381..494860 /gene="ydbS" /locus_tag="BSU_04590" /old_locus_tag="BSU04590" /label="ydbS gene" CDS 494850..496331 /gene="ydbT" /locus_tag="BSU_04600" /old_locus_tag="BSU04600" /experiment="publication(s) with functional evidences, PMID:16629676" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16629676; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="resistance to heterologous antibiotics" /protein_id="NP_388341.1" /db_xref="EnsemblGenomes-Gn:BSU04600" /db_xref="EnsemblGenomes-Tr:CAB12267" /db_xref="GOA:P96616" /db_xref="InterPro:IPR005182" /db_xref="InterPro:IPR014529" /db_xref="SubtiList:BG12087" /db_xref="UniProtKB/Swiss-Prot:P96616" /translation="MMSEPKRLHPVAVILNLCHTIIQTIKNIILPFFFVYIVNSNHTV RFYGAIALGVLFIWLVAASIIKWRRFTYRIEDDEFRIEEGLFVTKKRYISIDRIQTMN TSAGLVQQIFKLVKLQIETAGGGKEAEAVLSAISVEEAERIKEAVFKKKAQRRENELD EERLEAEEELDPSVEVQEHYRMNAKELLMAASTSGGIGVIISAVFALISQLDEVLPMD WLFDKFSFLQHASIGIYAVLIFIGLFIAWIFSIAGMMFRYANFQIIKKEQELVISRGI IEKHQVTIPLRKIQAIKIKENIIRQLFGFVTVSIVSAGGGDREKEEGALTILFPMIHK KKLPHMLRTFTPEYTLEENCRRLPRRALKRYLFRSVIFSLFLIIPLCIFFQPWGYLSV ILLPIELLFGYLAYKEAAWTINGDRLQLTSRFIGRTTAIVLKKRMQVCKFSQSYFQKK GRLYTISTSVKSSSHMEELTVRDVGEEDAAFILKWYSYEKADG*" /label="ydbT CDS" gene 494850..496331 /gene="ydbT" /locus_tag="BSU_04600" /old_locus_tag="BSU04600" /label="ydbT gene" downshifts 496301 /Source="Nicolas_upshifts" /id="D220" /incds=0 /nref=6 /ntot=162 /MaxReadThrough="4.90913" /MaxDrop="3.0931" /score="48.2239319" /energy="-17.1" /TU="U363" /idTUdmin="U364" /TUdmin="-638" /isTUend="FALSE" /label="downshifts" S_feature 496346..496673 /Source="Nicolas_S_feature" /locus_tag="new_514779_515106" /HighExp="Salt, T0.30H, G135, T1.0H, T1.30H, G150, G180, Oxctl, T-0.40H, aero" /AntisenseName="ydcA" /AntisenseCor="-0.25636523135066602" /AntisenseRegPval="-4.7" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S160" downshifts complement(496355) /Source="Nicolas_upshifts" /id="D221" /incds=0 /nref=1 /ntot=66 /MaxReadThrough="0.258529999999999" /MaxDrop="3.15455" /score="-3.74867023" /energy="-8.8" /TU="NA" /idTUdmin="U365" /TUdmin=220 /isTUend="FALSE" /label="downshifts" CDS complement(496583..497182) /gene="ydcA" /locus_tag="BSU_04610" /old_locus_tag="BSU04610" /EC_number="3.4.21.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15616571, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative rhomboid protease" /protein_id="NP_388342.1" /db_xref="EnsemblGenomes-Gn:BSU04610" /db_xref="EnsemblGenomes-Tr:CAB12268" /db_xref="GOA:P96617" /db_xref="InterPro:IPR022764" /db_xref="InterPro:IPR035952" /db_xref="SubtiList:BG12088" /db_xref="UniProtKB/Swiss-Prot:P96617" /translation="MFIRTENFQTFIRLYPVVTFILALQAVLWLFFSLPAHSVVLWRD TVTGYNLGVANGEWWRLITPILLHAGFTHLLFNSMSIFLFAPALERMLGKARFLLVYA GSGIIGNIGTYVTEPLDYVHVGASGAIFGLFGVYLFMVLFRNELIGQEHSKMIITLLA FAVLMSFINSNINMMAHLFGLCGGFLLSFLCVQKKERRY*" /label="ydcA CDS" gene complement(496583..497182) /gene="ydcA" /locus_tag="BSU_04610" /old_locus_tag="BSU04610" /label="ydcA gene" promotor_-35 496643..496648 /Source="Nicolas_upshift_promotors" /id="U364" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2751 /SigmaFactorBS="aaaacgaaagaagaaacccgccgcatagTCCAAAcaaatggg ccatCATGTTAATATTGGAGTTGAtaaacgacatgagaacggcaaatgcgagcagtgt g" /listShort="S161" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 496661..496680 /Source="Nicolas_upshift_promotors" /id="U364" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2751 /SigmaFactorBS="aaaacgaaagaagaaacccgccgcatagTCCAAAcaaatggg ccatCATGTTAATATTGGAGTTGAtaaacgacatgagaacggcaaatgcgagcagtgt g" /listShort="S161" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 496675..497276 /Source="Nicolas_S_feature" /locus_tag="new_515108_515709" /HighExp="Salt, G135, G150, T0.30H, G180, T1.0H, T1.30H, H2O2, Paraq, Oxctl" /AntisenseName="ydcA" /AntisenseCor="-0.11975373672841701" /AntisenseRegPval="-1.3" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S161" upshifts 496675 /Source="Nicolas_upshifts" /id="U364" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2751 /SigmaFactorBS="aaaacgaaagaagaaacccgccgcatagTCCAAAcaaatggg ccatCATGTTAATATTGGAGTTGAtaaacgacatgagaacggcaaatgcgagcagtgt g" /listShort="S161" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(497206..497225) /Source="Nicolas_upshift_promotors" /id="U365" /multdbtbs="SigE" /comp="M4" /sig="SigA" /pcomp="0.879120879120879" /psig="0.907092907092907" /xcortree=1402 /SigmaFactorBS="tgtatgataacctcctttgcgtacgtactatttaaatggttt gtctcataaaCGTGTTACTATAGATATACCaaaatgaagaaaaggggctcggaatgtt t" /listShort="ydcA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(497217) /Source="Nicolas_upshifts" /id="U365" /multdbtbs="SigE" /comp="M4" /sig="SigA" /pcomp="0.879120879120879" /psig="0.907092907092907" /xcortree=1402 /SigmaFactorBS="tgtatgataacctcctttgcgtacgtactatttaaatggttt gtctcataaaCGTGTTACTATAGATATACCaaaatgaagaaaaggggctcggaatgtt t" /listShort="ydcA" /GFF_Attribute="listLong" /label="upshifts" CDS 497277..497642 /gene="acpS" /locus_tag="BSU_04620" /old_locus_tag="BSU04620" /EC_number="2.7.8.7" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11489886, 11525165, 11867633, 12682299, 12926246, 15955059, 16597923; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="holo-acyl carrier protein synthase (phosphopantetheinyl transferase)" /protein_id="NP_388343.1" /db_xref="EnsemblGenomes-Gn:BSU04620" /db_xref="EnsemblGenomes-Tr:CAB12269" /db_xref="GOA:P96618" /db_xref="InterPro:IPR002582" /db_xref="InterPro:IPR004568" /db_xref="InterPro:IPR008278" /db_xref="InterPro:IPR037143" /db_xref="PDB:1F7L" /db_xref="PDB:1F7T" /db_xref="PDB:1F80" /db_xref="SubtiList:BG12089" /db_xref="UniProtKB/Swiss-Prot:P96618" /translation="MIYGIGLDITELKRIASMAGRQKRFAERILTRSELDQYYELSEK RKNEFLAGRFAAKEAFSKAFGTGIGRQLSFQDIEIRKDQNGKPYIICTKLSQAAVHVS ITHTKEYAAAQVVIERLSS*" /label="acpS CDS" gene 497277..497642 /gene="acpS" /locus_tag="BSU_04620" /old_locus_tag="BSU04620" /label="acpS gene" promotor_-35 497645..497650 /Source="Nicolas_upshift_promotors" /id="U366" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=976 /SigmaFactorBS="tgccgcgcaggttgtgattgaaaggttgtcaagctagtcTGC ATAttagggaaaccccacTCATATATTTGATAGTGCAttaagggagacaagttgtttg a" /listShort="S162, ydcC, alrA" /listLong="endB, ndoA" /label="promotor_-35" S_feature 497666..497807 /Source="Nicolas_S_feature" /locus_tag="new_516099_516240" /HighExp="S3, S4, BT, LoTm, S5, T5.0H, M9-stat, S7, T4.0H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigWXY" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S162" promotor_-10 497666..497684 /Source="Nicolas_upshift_promotors" /id="U366" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=976 /SigmaFactorBS="tgccgcgcaggttgtgattgaaaggttgtcaagctagtcTGC ATAttagggaaaccccacTCATATATTTGATAGTGCAttaagggagacaagttgtttg a" /listShort="S162, ydcC, alrA" /listLong="endB, ndoA" /label="promotor_-10" upshifts 497666 /Source="Nicolas_upshifts" /id="U366" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=976 /SigmaFactorBS="tgccgcgcaggttgtgattgaaaggttgtcaagctagtcTGC ATAttagggaaaccccacTCATATATTTGATAGTGCAttaagggagacaagttgtttg a" /listShort="S162, ydcC, alrA" /listLong="endB, ndoA" /label="upshifts" CDS 497808..498824 /gene="ydcC" /locus_tag="BSU_04630" /old_locus_tag="BSU04630" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14523133; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_388344.2" /db_xref="EnsemblGenomes-Gn:BSU04630" /db_xref="EnsemblGenomes-Tr:CAB12270" /db_xref="GOA:P96619" /db_xref="InterPro:IPR029046" /db_xref="SubtiList:BG12090" /db_xref="UniProtKB/Swiss-Prot:P96619" /translation="MKKVRKSFVLLLTGLLAVLILSACGQKTQQDIVAGLDEKAKEYT SYKAKAKMTIETGSEPQVYNVEIWHKKPSLYRVYLENPKKDQNQVILRNENGVFVLTP SLNKSFRFQSDWPNNSSQVYLFESLVKDVQNDSDAVFTAKEKKYVFETKTNYQHNKML PTQEITFNKKDMSPSSVKVMDTDRKVMVKVEFSSFEFNKQFDKESFDEKKNMTLSQMD VATSAKPSDTFAVKTPLELPLGVKLLEEKDISTEDGKRIIMTYGGEKSFTLIQEKAQI AKASSSVTLNGEPVNLGYTIGALSDASLSWTYDGVDYLLSSKDLSKEEMVTVAKSMQG QSSK*" /label="ydcC CDS" gene 497808..498824 /gene="ydcC" /locus_tag="BSU_04630" /old_locus_tag="BSU04630" /label="ydcC gene" downshifts 498809 /Source="Nicolas_upshifts" /id="D222" /incds=0 /nref=193 /ntot=256 /MaxReadThrough="3.39815" /MaxDrop="6.13946" /score="22.0391647" /energy="-9.5" /TU="U366" /idTUdmin="U363" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 498869..498876 /Source="Nicolas_upshift_promotors" /id="U367" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.652347652347652" /psig=1 /xcortree=1877 /SigmaFactorBS="aaacatgatttggcctttttttcgttagacatCGTTTCCCtt tagcctttaatTTTAGTATGATATGTAAATGatattgaataaaagctaggaagtgtcg t" /listShort="alrA, endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 498890..498909 /Source="Nicolas_upshift_promotors" /id="U367" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.652347652347652" /psig=1 /xcortree=1877 /SigmaFactorBS="aaacatgatttggcctttttttcgttagacatCGTTTCCCtt tagcctttaatTTTAGTATGATATGTAAATGatattgaataaaagctaggaagtgtcg t" /listShort="alrA, endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 498897 /Source="Nicolas_upshifts" /id="U367" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.652347652347652" /psig=1 /xcortree=1877 /SigmaFactorBS="aaacatgatttggcctttttttcgttagacatCGTTTCCCtt tagcctttaatTTTAGTATGATATGTAAATGatattgaataaaagctaggaagtgtcg t" /listShort="alrA, endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="upshifts" CDS 498939..500108 /gene="alrA" /locus_tag="BSU_04640" /old_locus_tag="BSU04640" /EC_number="5.1.1.1" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 2835089, 12682299, 15043879, 18399999, 25227915; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanine racemase" /protein_id="NP_388345.1" /db_xref="EnsemblGenomes-Gn:BSU04640" /db_xref="EnsemblGenomes-Tr:CAB12271" /db_xref="GOA:P10725" /db_xref="InterPro:IPR000821" /db_xref="InterPro:IPR001608" /db_xref="InterPro:IPR009006" /db_xref="InterPro:IPR011079" /db_xref="InterPro:IPR020622" /db_xref="InterPro:IPR029066" /db_xref="SubtiList:BG10950" /db_xref="UniProtKB/Swiss-Prot:P10725" /translation="MSTKPFYRDTWAEIDLSAIKENVSNMKKHIGEHVHLMAVVKANA YGHGDAETAKAALDAGASCLAVAILDEAISLRKKGLKAPILVLGAVPPEYVAIAAEYD VTLTGYSVEWLQEAARHTKKGSLHFHLKVDTGMNRLGVKTEEEVQNVMAILDRNPRLK CKGVFTHFATADEKERGYFLMQFERFKELIAPLPLKNLMVHCANSAAGLRLKKGFFNA VRFGIGMYGLRPSADMSDEIPFQLRPAFTLHSTLSHVKLIRKGESVSYGAEYTAEKDT WIGTVPVGYADGWLRKLKGTDILVKGKRLKIAGRICMDQFMVELDQEYPPGTKVTLIG RQGDEYISMDEIAGRLETINYEVACTISSRVPRMFLENGSIMEVRNPLLQVNISN*" /label="alrA CDS" gene 498939..500108 /gene="alrA" /locus_tag="BSU_04640" /old_locus_tag="BSU04640" /label="alrA gene" promotor_-35 500037..500042 /Source="Nicolas_upshift_promotors" /id="U368" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.93906093906094" /psig="0.93906093906094" /xcortree=1177 /SigmaFactorBS="tgaggtggcctgtacaataagttcccgtgttcccCGTATGtt tttggaaaatggGAGTATAATGGAAGTAAGAaatcctttattgcaggtaaatataagc a" /listShort="endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 500057..500075 /Source="Nicolas_upshift_promotors" /id="U368" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.93906093906094" /psig="0.93906093906094" /xcortree=1177 /SigmaFactorBS="tgaggtggcctgtacaataagttcccgtgttcccCGTATGtt tttggaaaatggGAGTATAATGGAAGTAAGAaatcctttattgcaggtaaatataagc a" /listShort="endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 500063 /Source="Nicolas_upshifts" /id="U368" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.93906093906094" /psig="0.93906093906094" /xcortree=1177 /SigmaFactorBS="tgaggtggcctgtacaataagttcccgtgttcccCGTATGtt tttggaaaatggGAGTATAATGGAAGTAAGAaatcctttattgcaggtaaatataagc a" /listShort="endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 500138..500141 /Source="Nicolas_upshift_promotors" /id="U369" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.527472527472527" /psig=1 /xcortree=2132 /SigmaFactorBS="taagcaattaacttacctaaatggagaattcataaaacagCT TTgcttgaagagtgaatAATGGTATCATTATCACTGGatggataaaagagtcgtatcc g" /listShort="endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 500157..500176 /Source="Nicolas_upshift_promotors" /id="U369" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.527472527472527" /psig=1 /xcortree=2132 /SigmaFactorBS="taagcaattaacttacctaaatggagaattcataaaacagCT TTgcttgaagagtgaatAATGGTATCATTATCACTGGatggataaaagagtcgtatcc g" /listShort="endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 500158 /Source="Nicolas_upshifts" /id="U369" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.527472527472527" /psig=1 /xcortree=2132 /SigmaFactorBS="taagcaattaacttacctaaatggagaattcataaaacagCT TTgcttgaagagtgaatAATGGTATCATTATCACTGGatggataaaagagtcgtatcc g" /listShort="endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="upshifts" CDS 500224..500505 /gene="ndoAI" /locus_tag="BSU_04650" /old_locus_tag="BSU04650" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15882409, 21763692, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15882409, 21763692, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="antitoxin EndoAI" /protein_id="NP_388346.1" /db_xref="EnsemblGenomes-Gn:BSU04650" /db_xref="EnsemblGenomes-Tr:CAB12272" /db_xref="GOA:P96621" /db_xref="InterPro:IPR002145" /db_xref="InterPro:IPR010985" /db_xref="InterPro:IPR013321" /db_xref="PDB:4ME7" /db_xref="SubtiList:BG12091" /db_xref="UniProtKB/Swiss-Prot:P96621" /translation="MSESSARTEMKISLPENLVAELDGVAMREKRSRNELISQAVRAY VSERTTRHNRDLMRRGYMEMAKINLNISSEAHFAECEAETTVERLVSGG*" /label="ndoAI CDS" gene 500224..500505 /gene="ndoAI" /locus_tag="BSU_04650" /old_locus_tag="BSU04650" /label="ndoAI gene" CDS 500510..500860 /gene="ndoA" /locus_tag="BSU_04660" /old_locus_tag="BSU04660" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15882409, 21763692, 21897862, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15882409, 21763692, 21897862, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endoribonuclease toxin" /protein_id="NP_388347.1" /db_xref="EnsemblGenomes-Gn:BSU04660" /db_xref="EnsemblGenomes-Tr:CAB12273" /db_xref="GOA:P96622" /db_xref="InterPro:IPR003477" /db_xref="InterPro:IPR011067" /db_xref="PDB:1NE8" /db_xref="PDB:4MDX" /db_xref="PDB:4ME7" /db_xref="SubtiList:BG12092" /db_xref="UniProtKB/Swiss-Prot:P96622" /translation="MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTAIV AAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQIRTIDKQRLTDKITHLDDEMMDK VDEALQISLALIDF*" /label="ndoA CDS" gene 500510..500860 /gene="ndoA" /locus_tag="BSU_04660" /old_locus_tag="BSU04660" /label="ndoA gene" S_feature complement(500650..501126) /Source="Nicolas_S_feature" /locus_tag="new_519083_519559_c" /HighExp="Etha, Gly, Sw, S8, C30, S6, LBGstat, T0.30H, S7, Salt" /AntisenseName="ndoA" /AntisenseCor="-0.36117231948253697" /AntisenseRegPval="-9" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigB, SigK" /TUshortPSig="1, 1, 0.973" /TUlongSig="NA" /TUlongPSig="NA" /label="S163" downshifts complement(500693) /Source="Nicolas_upshifts" /id="D223" /incds=1 /nref=6 /ntot=171 /MaxReadThrough="3.51096" /MaxDrop="3.79912" /score="-8.86444162" /energy="-10.2" /TU="U372" /idTUdmin="U371" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" downshifts 500840 /Source="Nicolas_upshifts" /id="D224" /incds=0 /nref=143 /ntot=254 /MaxReadThrough="5.57908" /MaxDrop="5.74865" /score="29.7721113" /energy="-8.9" /TU="U367,U368,U369" /idTUdmin="U366" /TUdmin=799 /isTUend="FALSE" /label="downshifts" promotor_-35 500894..500901 /Source="Nicolas_upshift_promotors" /id="U370" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.772227772227772" /psig="0.999000999001" /xcortree=1992 /SigmaFactorBS="atatttgcaggttgctcaaatagagcaacttTTTTTGTTttc aaaaaacataAACGATATAATAGTGAAATAacgaaaaaatatgttgttttttattggg a" /listShort="rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 500915..500934 /Source="Nicolas_upshift_promotors" /id="U370" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.772227772227772" /psig="0.999000999001" /xcortree=1992 /SigmaFactorBS="atatttgcaggttgctcaaatagagcaacttTTTTTGTTttc aaaaaacataAACGATATAATAGTGAAATAacgaaaaaatatgttgttttttattggg a" /listShort="rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 500923 /Source="Nicolas_upshifts" /id="U370" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.772227772227772" /psig="0.999000999001" /xcortree=1992 /SigmaFactorBS="atatttgcaggttgctcaaatagagcaacttTTTTTGTTttc aaaaaacataAACGATATAATAGTGAAATAacgaaaaaatatgttgttttttattggg a" /listShort="rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="upshifts" CDS 500975..501799 /gene="rsbRA" /locus_tag="BSU_04670" /old_locus_tag="BSU04670" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15312768, 15583165, 16963570, 17158665, 11157946, 20019076, 21362065, 22287516, 23320651, 28271471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15312768, 15583165, 16963570, 17158665, 11157946, 20019076, 21362065, 22287516, 23320651, 28271471; Product type f: factor" /codon_start=1 /transl_table=11 /product="component of the anxiosome (stressosome); positive regulation of sigma(B) activity in response to salt and heat stress" /protein_id="NP_388348.1" /db_xref="EnsemblGenomes-Gn:BSU04670" /db_xref="EnsemblGenomes-Tr:CAB12274" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR014792" /db_xref="InterPro:IPR036513" /db_xref="PDB:2BNL" /db_xref="SubtiList:BG11090" /db_xref="UniProtKB/Swiss-Prot:P42409" /translation="MMSNQTVYQFIAENQNELLQLWTDTLKELSEQESYQLTDQVYEN ISKEYIDILLLSVKDENAAESQISELALRAVQIGLSMKFLATALAEFWKRLYTKMNDK RLPDQESTELIWQIDRFFSPINTEIFNQYSISWEKTVSLQKIALQELSAPLIPVFENI TVMPLVGTIDTERAKRIMENLLNGVVKHRSQVVLIDITGVPVVDTMVAHHIIQASEAV RLVGAKCLLAGIRPEIAQTIVNLGIDLSQVITKNTLQKGIQTALEMTDRKIVSLGE*" /label="rsbRA CDS" gene 500975..501799 /gene="rsbRA" /locus_tag="BSU_04670" /old_locus_tag="BSU04670" /label="rsbRA gene" promotor_-10 complement(501109..501127) /Source="Nicolas_upshift_promotors" /id="U371" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2828 /SigmaFactorBS="gccagttcgctgatttggctttcagcagcattttcgtcCTTA ACAGacagcagcagaatGTCGATATATTCTTTAGATatattttcatacacttggtcag t" /listShort="S163" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(501126) /Source="Nicolas_upshifts" /id="U371" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2828 /SigmaFactorBS="gccagttcgctgatttggctttcagcagcattttcgtcCTTA ACAGacagcagcagaatGTCGATATATTCTTTAGATatattttcatacacttggtcag t" /listShort="S163" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(501128..501727) /Source="Nicolas_S_feature" /locus_tag="new_519561_520160_c" /HighExp="Etha, Sw, Gly, S6, S8, S7, B60, Salt, BT, M9-stat" /AntisenseName="rsbRA" /AntisenseCor="-0.53924606340364201" /AntisenseRegPval="-21" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigK" /TUshortPSig="1, 0.973" /TUlongSig="NA" /TUlongPSig="NA" /label="S164" promotor_-35 complement(501141..501148) /Source="Nicolas_upshift_promotors" /id="U371" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2828 /SigmaFactorBS="gccagttcgctgatttggctttcagcagcattttcgtcCTTA ACAGacagcagcagaatGTCGATATATTCTTTAGATatattttcatacacttggtcag t" /listShort="S163" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(501716..501734) /Source="Nicolas_upshift_promotors" /id="U372" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=202 /SigmaFactorBS="tgaaacgatttttcgatccgtcatttccaatgcTGTTTGAat tcctttttgcaGGGTATTCTTAGTTATAACttgggataaatcaatccccaggttgacg a" /listShort="S164, S163" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(501727) /Source="Nicolas_upshifts" /id="U372" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=202 /SigmaFactorBS="tgaaacgatttttcgatccgtcatttccaatgcTGTTTGAat tcctttttgcaGGGTATTCTTAGTTATAACttgggataaatcaatccccaggttgacg a" /listShort="S164, S163" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(501729..502317) /Source="Nicolas_S_feature" /locus_tag="new_520162_520750_c" /HighExp="S6, S8, S7, BT, C30, S5, G135, C90, Gly, Fru" /AntisenseName="rsbS" /AntisenseCor="-0.57706416777859804" /AntisenseRegPval="-24.6" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.973" /TUlongSig="NA" /TUlongPSig="NA" /label="S165" promotor_-35 complement(501748..501754) /Source="Nicolas_upshift_promotors" /id="U372" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=202 /SigmaFactorBS="tgaaacgatttttcgatccgtcatttccaatgcTGTTTGAat tcctttttgcaGGGTATTCTTAGTTATAACttgggataaatcaatccccaggttgacg a" /listShort="S164, S163" /GFF_Attribute="listLong" /label="promotor_-35" CDS 501804..502169 /gene="rsbS" /locus_tag="BSU_04680" /old_locus_tag="BSU04680" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15583165, 16963570, 17158665, 11157946, 23320651, 28271471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15583165, 16963570, 17158665, 11157946, 23320651, 28271471; Product type f : factor" /codon_start=1 /transl_table=11 /product="antagonist of RsbT" /protein_id="NP_388349.1" /db_xref="EnsemblGenomes-Gn:BSU04680" /db_xref="EnsemblGenomes-Tr:CAB12275" /db_xref="GOA:P42410" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR036513" /db_xref="SubtiList:BG11091" /db_xref="UniProtKB/Swiss-Prot:P42410" /translation="MRHPKIPILKLYNCLLVSIQWELDDQTALTFQEDLLNKIYETGA NGVVIDLTSVDMIDSFIAKVLGDVITMSKLMGAKVVLTGIQPAVAVTLIELGIALEEI ETALDLEQGLETLKRELGE*" /label="rsbS CDS" gene 501804..502169 /gene="rsbS" /locus_tag="BSU_04680" /old_locus_tag="BSU04680" /label="rsbS gene" CDS 502173..502574 /gene="rsbT" /locus_tag="BSU_04690" /old_locus_tag="BSU04690" /EC_number="2.7.11.1" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15583165, 16963570, 17158665, 11157946, 20019076, 20558511, 21362065, 21979936, 23320651" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15583165, 16963570, 17158665, 11157946, 20019076, 20558511, 21362065, 21979936, 23320651; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="switch protein/serine-threonine kinase; controlsthe activity of the anxiosome (stressosome)" /protein_id="NP_388350.1" /db_xref="EnsemblGenomes-Gn:BSU04690" /db_xref="EnsemblGenomes-Tr:CAB12276" /db_xref="GOA:P42411" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11092" /db_xref="UniProtKB/Swiss-Prot:P42411" /translation="MNDQSCVRIMTEWDIVAARQLGRNVAKELGFGTVDQARITTAIS ELARNIYLYAGKGQIGIEQVADRGKKGLKIIAEDQGPGIPDIRKVMEDGFSTSGGLGA GLPGVKRLMDEFSLNSVAGEGTEIQAIKWLR*" /label="rsbT CDS" gene 502173..502574 /gene="rsbT" /locus_tag="BSU_04690" /old_locus_tag="BSU04690" /label="rsbT gene" promotor_-10 complement(502315..502334) /Source="Nicolas_upshift_promotors" /id="U373" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1334 /SigmaFactorBS="ttttcaggcctttttttcctctgtctgcgacctgtTCAATTC CAAtctgccctttgccGGCATATAAATAAATATTCCtggctaattctgaaatagccgt t" /listShort="S165, S164, S163" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(502332) /Source="Nicolas_upshifts" /id="U373" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1334 /SigmaFactorBS="ttttcaggcctttttttcctctgtctgcgacctgtTCAATTC CAAtctgccctttgccGGCATATAAATAAATATTCCtggctaattctgaaatagccgt t" /listShort="S165, S164, S163" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(502348..502357) /Source="Nicolas_upshift_promotors" /id="U373" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1334 /SigmaFactorBS="ttttcaggcctttttttcctctgtctgcgacctgtTCAATTC CAAtctgccctttgccGGCATATAAATAAATATTCCtggctaattctgaaatagccgt t" /listShort="S165, S164, S163" /GFF_Attribute="listLong" /label="promotor_-35" CDS 502586..503593 /gene="rsbU" /locus_tag="BSU_04700" /old_locus_tag="BSU04700" /EC_number="3.1.3.3" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15583165, 16963570, 17158665, 17303566, 21979936, 28461450" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15583165, 16963570, 17158665, 17303566, 21979936, 28461450; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="protein serine phosphatase; controls the activity of the anxiosome (stressosome)" /protein_id="NP_388351.1" /db_xref="EnsemblGenomes-Gn:BSU04700" /db_xref="EnsemblGenomes-Tr:CAB12277" /db_xref="GOA:P40399" /db_xref="InterPro:IPR001932" /db_xref="InterPro:IPR014787" /db_xref="InterPro:IPR017944" /db_xref="InterPro:IPR036457" /db_xref="PDB:1W53" /db_xref="PDB:2J6Y" /db_xref="PDB:2J6Z" /db_xref="PDB:2J70" /db_xref="SubtiList:BG11057" /db_xref="UniProtKB/Swiss-Prot:P40399" /translation="MDFREVIEQRYHQLLSRYIAELTETSLYQAQKFSRKTIEHQIPP EEIISIHRKVLKELYPSLPEDVFHSLDFLIEVMIGYGMAYQEHQTLRGIQQEIKSEIE IAANVQQTLLGTKVPQEEALDIGAISVPAKQMSGDYYHFVKDKESINIAIADVIGKGI PAALCMSMIKYAMDSLPETGIHPSQVLKNLNRVVEQNVDASMFITMFYANYNMDKHQF TYASAGHEPGFYYSQKDNTFYDLEAKGLVLGISQDYDYKQFDQHLEKGDMIVLFSDGV TECRTENGFLERPDLQKLIEEHMCSSAQEMVKNIYDSLLKLQDFQLHDDFTLIVLRRK V*" /label="rsbU CDS" gene 502586..503593 /gene="rsbU" /locus_tag="BSU_04700" /old_locus_tag="BSU04700" /label="rsbU gene" promotor_-35 503587..503593 /Source="Nicolas_upshift_promotors" /id="U374" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=260 /SigmaFactorBS="cgatgattttacgttaattgttttgcggagaaaGGTTTAAcg tctgtcagacgaGGGTATAAAGCAACTAGTGatttgaaggaaaatttgaggtgatacg a" /listShort="rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 503608..503626 /Source="Nicolas_upshift_promotors" /id="U374" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=260 /SigmaFactorBS="cgatgattttacgttaattgttttgcggagaaaGGTTTAAcg tctgtcagacgaGGGTATAAAGCAACTAGTGatttgaaggaaaatttgaggtgatacg a" /listShort="rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 503614 /Source="Nicolas_upshifts" /id="U374" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=260 /SigmaFactorBS="cgatgattttacgttaattgttttgcggagaaaGGTTTAAcg tctgtcagacgaGGGTATAAAGCAACTAGTGatttgaaggaaaatttgaggtgatacg a" /listShort="rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="upshifts" CDS 503655..503984 /gene="rsbV" /locus_tag="BSU_04710" /old_locus_tag="BSU04710" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15342585, 15583165, 16077134, 16885458, 20454630, 21979936, 27977677" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15342585, 15583165, 16077134, 16885458, 20454630, 21979936, 27977677; Product type f: factor" /codon_start=1 /transl_table=11 /product="anti-anti-sigma factor (antagonist of RsbW)" /protein_id="NP_388352.1" /db_xref="EnsemblGenomes-Gn:BSU04710" /db_xref="EnsemblGenomes-Tr:CAB12278" /db_xref="GOA:P17903" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR003658" /db_xref="InterPro:IPR036513" /db_xref="SubtiList:BG10733" /db_xref="UniProtKB/Swiss-Prot:P17903" /translation="MNINVDVKQNENDIQVNIAGEIDVYSAPVLREKLVPLAEQGADL RICLKDVSYMDSTGLGVFVGTFKMVKKQGGSLKLENLSERLIRLFDITGLKDIIDISA KSEGGVQ*" /label="rsbV CDS" gene 503655..503984 /gene="rsbV" /locus_tag="BSU_04710" /old_locus_tag="BSU04710" /label="rsbV gene" CDS 503981..504463 /gene="rsbW" /locus_tag="BSU_04720" /old_locus_tag="BSU04720" /EC_number="2.7.11.1" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15342585, 15583165, 16077134, 16885458, 21979936, 27977677" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15342585, 15583165, 16077134, 16885458, 21979936, 27977677; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="switch protein/serine kinase and anti-sigma factor (inhibitory sigma-B binding protein)" /protein_id="NP_388353.1" /db_xref="EnsemblGenomes-Gn:BSU04720" /db_xref="EnsemblGenomes-Tr:CAB12279" /db_xref="GOA:P17904" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR010193" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10734" /db_xref="UniProtKB/Swiss-Prot:P17904" /translation="MKNNADYIEMKVPAQPEYVGIIRLTLSGVASRMGYTYDEIEDLK IAVSEACTNAVQHAYKEDKNGEVSIRFGVFEDRLEVIVADEGDSFDFDQKQQDLGPYT PSHTVDQLSEGGLGLYLMETLMDEVRVQNHSGVTVAMTKYLNGERVDHDTTIKNYETN *" /label="rsbW CDS" gene 503981..504463 /gene="rsbW" /locus_tag="BSU_04720" /old_locus_tag="BSU04720" /label="rsbW gene" CDS 504429..505217 /gene="sigB" /locus_tag="BSU_04730" /old_locus_tag="BSU04730" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15312768, 15805528, 16077134, 16267279, 16321960, 17158665, 28271471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15312768, 15805528, 16077134, 16267279, 16321960, 17158665, 28271471; Product type r: regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase sigma-37 factor (sigma(B))" /protein_id="NP_388354.2" /db_xref="EnsemblGenomes-Gn:BSU04730" /db_xref="EnsemblGenomes-Tr:CAB12280" /db_xref="GOA:P06574" /db_xref="InterPro:IPR000943" /db_xref="InterPro:IPR007624" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR007630" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR014288" /db_xref="InterPro:IPR014322" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10735" /db_xref="UniProtKB/Swiss-Prot:P06574" /translation="MTQPSKTTKLTKDEVDRLISDYQTKQDEQAQETLVRVYTNLVDM LAKKYSKGKSFHEDLRQVGMIGLLGAIKRYDPVVGKSFEAFAIPTIIGEIKRFLRDKT WSVHVPRRIKELGPRIKMAVDQLTTETQRSPKVEEIAEFLDVSEEEVLETMEMGKSYQ ALSVDHSIEADSDGSTVTILDIVGSQEDGYERVNQQLMLQSVLHVLSDREKQIIDLTY IQNKSQKETGDILGISQMHVSRLQRKAVKKLREALIEDPSMELM*" /label="sigB CDS" gene 504429..505217 /gene="sigB" /locus_tag="BSU_04730" /old_locus_tag="BSU04730" /label="sigB gene" CDS 505217..505816 /gene="rsbX" /locus_tag="BSU_04740" /old_locus_tag="BSU04740" /EC_number="3.1.3.3" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10671474, 12950928, 15466036, 9068644, 9658013, 21979936, 26057679" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10671474, 12950928, 15466036, 9068644, 9658013, 21979936, 26057679; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="serine phosphatase" /protein_id="NP_388355.1" /db_xref="EnsemblGenomes-Gn:BSU04740" /db_xref="EnsemblGenomes-Tr:CAB12281" /db_xref="GOA:P17906" /db_xref="InterPro:IPR001932" /db_xref="InterPro:IPR036457" /db_xref="PDB:3W40" /db_xref="PDB:3W41" /db_xref="PDB:3W42" /db_xref="PDB:3W43" /db_xref="PDB:3W44" /db_xref="PDB:3W45" /db_xref="SubtiList:BG10736" /db_xref="UniProtKB/Swiss-Prot:P17906" /translation="MIQVEENEHIQTLVYQLNKEGKSICGDSFFMKADDKELICAVAD GLGSGSLANESSAAIKDLVENYASEDVESIIERCNQAMKNKRGATASILKINFEQRQF TYCSVGNVRFILHSPSGESFYPLPISGYLSGKPQKYKTHTATYEKGSKFIIHTDGLNV PDIRSHLKKGQSVEEISNSLKMYTTSRKDDLTYILGQLS*" /label="rsbX CDS" gene 505217..505816 /gene="rsbX" /locus_tag="BSU_04740" /old_locus_tag="BSU04740" /label="rsbX gene" downshifts 505802 /Source="Nicolas_upshifts" /id="D225" /incds=0 /nref=267 /ntot=278 /MaxReadThrough="2.46753" /MaxDrop="7.92167" /score="1.26147577" /energy="-6" /TU="NA" /idTUdmin="U369" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" promotor_-35 505860..505866 /Source="Nicolas_upshift_promotors" /id="U375" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.427572427572428" /psig=1 /xcortree=2529 /SigmaFactorBS="gctggacatccggcttcttttttttgcGGTTGACtattaata agtgcgCTTATTATAATTAATAAGTGaacttatcattctgggagcttatgggatgtgg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 505881..505900 /Source="Nicolas_upshift_promotors" /id="U375" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.427572427572428" /psig=1 /xcortree=2529 /SigmaFactorBS="gctggacatccggcttcttttttttgcGGTTGACtattaata agtgcgCTTATTATAATTAATAAGTGaacttatcattctgggagcttatgggatgtgg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" Polymorphism join(505889,505891) /Source="geneious" /ID="SNP_BsDelta6_524323_524323" /Polymorphism_Type="SNP (transversion)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change /CDS_Position /Change="A -> C" /Codon_Change /Coverage=183 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides="A" /Variant_Nucleotides="C" /Variant_P_Value=0 /Variant_Raw_Frequency=183 /comment="BSU_04745_promoter_down_mutation" /modified_by="User" / /label="Polymorphism_Delta6" upshifts 505893 /Source="Nicolas_upshifts" /id="U375" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.427572427572428" /psig=1 /xcortree=2529 /SigmaFactorBS="gctggacatccggcttcttttttttgcGGTTGACtattaata agtgcgCTTATTATAATTAATAAGTGaacttatcattctgggagcttatgggatgtgg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 505927..506043 /locus_tag="BSU_04745" /old_locus_tag="BSU04745" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513945.1" /translation="MWNYEYTAIADVDVGKPGTVIRKQKQWINGRRVLHQIL*" /label="hypothetical protein CDS" gene 505927..506043 /locus_tag="BSU_04745" /old_locus_tag="BSU04745" /label="gene" CDS 506059..506352 /gene="ydcF" /locus_tag="BSU_04750" /old_locus_tag="BSU04750" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388356.1" /db_xref="EnsemblGenomes-Gn:BSU04750" /db_xref="EnsemblGenomes-Tr:CAB12282" /db_xref="SubtiList:BG12093" /db_xref="UniProtKB/Swiss-Prot:P96623" /translation="MERKEHCFCKEKQFSYGLSMWRNIGRFLSWSTCPHSNVIMEFFH VLQKQKEDLCITYGIVLEGAEAKKWGEIIGTELSKDMPTAVSRLVHLYGGVIK*" /label="ydcF CDS" gene 506059..506352 /gene="ydcF" /locus_tag="BSU_04750" /old_locus_tag="BSU04750" /label="ydcF gene" promotor_-35 506320..506328 /Source="Nicolas_upshift_promotors" /id="U376" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.65034965034965" /psig=1 /xcortree=2272 /SigmaFactorBS="agacatgccgacggctgtcagcaggCTTGTCCATctttacgg aggAGTGATAAAATGAACACAAAttactggatcggcgttgtgtcagagcaacatgtat t" /listShort="ydcG, ydcH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 506340..506359 /Source="Nicolas_upshift_promotors" /id="U376" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.65034965034965" /psig=1 /xcortree=2272 /SigmaFactorBS="agacatgccgacggctgtcagcaggCTTGTCCATctttacgg aggAGTGATAAAATGAACACAAAttactggatcggcgttgtgtcagagcaacatgtat t" /listShort="ydcG, ydcH" /GFF_Attribute="listLong" /label="promotor_-10" CDS 506349..506789 /gene="ydcG" /locus_tag="BSU_04760" /old_locus_tag="BSU04760" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388357.1" /db_xref="EnsemblGenomes-Gn:BSU04760" /db_xref="EnsemblGenomes-Tr:CAB12283" /db_xref="InterPro:IPR002740" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR022996" /db_xref="SubtiList:BG12094" /db_xref="UniProtKB/Swiss-Prot:P96624" /translation="MNTNYWIGVVSEQHVLKGAAGGFAQLCHGKKAPLAKMKEGDWLI YYSPRDAYPDGKLLRSFTAIGKVKSGNIYPYQMAPNFIPYRLDIDYYPCHKIGFYDIK SKLEFVQETKHLGFLFRRGHFEISKKDFLTIAQAMGVNISGMAL*" /label="ydcG CDS" gene 506349..506789 /gene="ydcG" /locus_tag="BSU_04760" /old_locus_tag="BSU04760" /label="ydcG gene" upshifts 506355 /Source="Nicolas_upshifts" /id="U376" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.65034965034965" /psig=1 /xcortree=2272 /SigmaFactorBS="agacatgccgacggctgtcagcaggCTTGTCCATctttacgg aggAGTGATAAAATGAACACAAAttactggatcggcgttgtgtcagagcaacatgtat t" /listShort="ydcG, ydcH" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(506588..509643) /Source="Nicolas_S_feature" /locus_tag="new_525021_528076_c" /HighExp="S6, S8, S7, S5, B36, S4, B60, BT, Pyr, C30" /AntisenseName="ydcI" /AntisenseCor="-0.61304426345041496" /AntisenseRegPval="-28.4" /CDS_PredictionProba="0.40759499999999999" /TUshortSig="SigK" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S166" CDS 506773..507216 /gene="ydcH" /locus_tag="BSU_04770" /old_locus_tag="BSU04770" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12088660; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_388358.1" /db_xref="EnsemblGenomes-Gn:BSU04770" /db_xref="EnsemblGenomes-Tr:CAB12284" /db_xref="GOA:P96625" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12095" /db_xref="UniProtKB/Swiss-Prot:P96625" /translation="MEWHSKFSGPNTSPGFLLWQATQSWQRKVGKALAEFDLTHVQFV LLTSCKYMIAHGETVTQKKLASFSQTNIMMVSEVVRTLEKKGFIERSKNPQDKREVLL SLTEIGGEKVTAALPIVEKIDQAFFAAAMKKENFLSGLQELLKHE*" /label="ydcH CDS" gene 506773..507216 /gene="ydcH" /locus_tag="BSU_04770" /old_locus_tag="BSU04770" /label="ydcH gene" downshifts 507191 /Source="Nicolas_upshifts" /id="D226" /incds=0 /nref=11 /ntot=147 /MaxReadThrough="2.17786" /MaxDrop="3.86856" /score="21.3746204" /energy="-6.8" /TU="NA" /idTUdmin="U376" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 507247..507248 /Source="Nicolas_upshift_promotors" /id="U377" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.712287712287712" /psig="0.997002997002997" /xcortree=1998 /SigmaFactorBS="gaaacatgagtaaagatacgggcagcgccagctgtctttttt tATgtgtttttttcggttTTTGATACACTAGAGAAAGAacgacaaaattggaggcttt g" /listShort="ydcI, S167, ydcK" /listLong="S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1, trnS-Leu2" /label="promotor_-35" promotor_-10 507264..507283 /Source="Nicolas_upshift_promotors" /id="U377" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.712287712287712" /psig="0.997002997002997" /xcortree=1998 /SigmaFactorBS="gaaacatgagtaaagatacgggcagcgccagctgtctttttt tATgtgtttttttcggttTTTGATACACTAGAGAAAGAacgacaaaattggaggcttt g" /listShort="ydcI, S167, ydcK" /listLong="S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1, trnS-Leu2" /label="promotor_-10" upshifts 507264 /Source="Nicolas_upshifts" /id="U377" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.712287712287712" /psig="0.997002997002997" /xcortree=1998 /SigmaFactorBS="gaaacatgagtaaagatacgggcagcgccagctgtctttttt tATgtgtttttttcggttTTTGATACACTAGAGAAAGAacgacaaaattggaggcttt g" /listShort="ydcI, S167, ydcK" /listLong="S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1, trnS-Leu2" /label="upshifts" CDS 507310..509469 /gene="tex" /locus_tag="BSU_04780" /old_locus_tag="BSU04780" /function="16.3: Control" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8755871, 12910271, 15383836, 16282592; Product type f: factor" /codon_start=1 /transl_table=11 /product="RNA helicase transcriptional accessory protein" /protein_id="NP_388359.2" /db_xref="EnsemblGenomes-Gn:BSU04780" /db_xref="EnsemblGenomes-Tr:CAB12285" /db_xref="GOA:O31489" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR006641" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR018974" /db_xref="InterPro:IPR022967" /db_xref="InterPro:IPR023319" /db_xref="InterPro:IPR023323" /db_xref="InterPro:IPR032639" /db_xref="SubtiList:BG12096" /db_xref="UniProtKB/Swiss-Prot:O31489" /translation="METSALLKQQIAKEIGLSQKHVESVIRLLEDGNTVPFIARYRKE QTGSMDEVQIQTISERWQYIQNLNQRKEEVIRLIAEQDKLTDNLKRKIEQSVKLQEVE DLYRPYKQKRKTKATVAKSKGLEPLADYILTLPQDDHLAATADQYISEEKEVFTREEA IEGAKHIIAEQISDEPTFRKWIRQETFKRGTIKSAAGKSADTDEKNVYEMYYEYEEPI AKVVPHRVLAMNRGEKEDILKVAIEPPADHIKAYLEKQIIKNRSTSVREILQETIEDS YKRLIQPAIEREIRKELSEKADEQAIHIFSENLRKLLLQPPMKGKTVLGVDPAFRTGC KLAVSDETGKVLKIDVIYPHAPVNKTKEAHEKVKKILEQYQVEMVAIGNGTASRETEQ FIVNVLRDMPRKIYYVIVNEAGASVYSASELAREEFPDLKVEERSAVSIARRLQDPLA ELVKIDPKSVGVGQYQHDVSQKRLNESLRFVVETVVNQVGVNVNTASAALLQYVAGLS KSVAGNVVKKREEIGKFSNRKELKDIPRLGAKTYEQCIGFLRVQEGTEPLDRTGIHPE SYKETKALLKKLGLSTEHIGTAELKDKINQLALSETAKELGIGEITLKDICEQLTRPE RDPRDKVPKPLLKTDVLQLEDLKEGMELQGTVRNVVDFGAFVDIGVKQDGLVHISKLS NQFVKHPLDVVSVGDIVTVWVDGVDVQKGRVSLSMVK*" /label="tex CDS" gene 507310..509469 /gene="tex" /locus_tag="BSU_04780" /old_locus_tag="BSU04780" /label="tex gene" misc_feature 509457..509476 /Source="Nicolas_upshift_promotors" /id="U378" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig="0.999000999001" /xcortree=2162 /SigmaFactorBS="gacggcgtagatgtacaaaaaggcagagtatcgctgtcTATG GTAAAATAAAAGCACTgcttacgagcagtgttttttcctatagaaataccagcattga t" /listShort="S167, ydcK, S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1" /listLong="trnS-Leu2, S169" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 509479..509695 /Source="Nicolas_S_feature" /locus_tag="new_527912_528128" /HighExp="Cold, Etha, LBGstat, dia5, LPhT, T4.0H, dia15, T3.0H, T2.30H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S167" upshifts 509479 /Source="Nicolas_upshifts" /id="U378" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig="0.999000999001" /xcortree=2162 /SigmaFactorBS="gacggcgtagatgtacaaaaaggcagagtatcgctgtcTATG GTAAAATAAAAGCACTgcttacgagcagtgttttttcctatagaaataccagcattga t" /listShort="S167, ydcK, S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1" /listLong="trnS-Leu2, S169" /label="upshifts" CDS complement(509479..509592) /gene="cmpA" /locus_tag="BSU_04785" /old_locus_tag="BSU04785" /function="16.3: Control" /function="16.6: Maintain" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:22463703, 26387458" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22463703, 26387458; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor allowing degradation of SpoIVA by ClpXP" /protein_id="YP_009513946.1" /translation="MPNWLKKQMQKAFLEKDNYQIKLLNQCWYFYRKKHCS*" /label="cmpA CDS" gene complement(509479..509592) /gene="cmpA" /locus_tag="BSU_04785" /old_locus_tag="BSU04785" /label="cmpA gene" promotor_-10 complement(509632..509651) /Source="Nicolas_upshift_promotors" /id="U379" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1320 /SigmaFactorBS="tctttgttatccatggtgcacctcacttaaaaaacATTGAAC GGgacaattcaccgttCGCATACAATATGGTAATCActgtccctcttatgataaaagc t" /listShort="S166" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(509649) /Source="Nicolas_upshifts" /id="U379" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1320 /SigmaFactorBS="tctttgttatccatggtgcacctcacttaaaaaacATTGAAC GGgacaattcaccgttCGCATACAATATGGTAATCActgtccctcttatgataaaagc t" /listShort="S166" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(509666..509674) /Source="Nicolas_upshift_promotors" /id="U379" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1320 /SigmaFactorBS="tctttgttatccatggtgcacctcacttaaaaaacATTGAAC GGgacaattcaccgttCGCATACAATATGGTAATCActgtccctcttatgataaaagc t" /listShort="S166" /GFF_Attribute="listLong" /label="promotor_-35" CDS 509696..510148 /gene="ydcK" /locus_tag="BSU_04790" /old_locus_tag="BSU04790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388360.1" /db_xref="EnsemblGenomes-Gn:BSU04790" /db_xref="EnsemblGenomes-Tr:CAB12286" /db_xref="GOA:P96628" /db_xref="InterPro:IPR006640" /db_xref="InterPro:IPR023524" /db_xref="InterPro:IPR035240" /db_xref="SubtiList:BG12098" /db_xref="UniProtKB/Swiss-Prot:P96628" /translation="MDNKELQKLTEDISETYFKKPFRHQALFNDRLKTTGGRYLLTSH NIELNRKYLIEHGREELIGIIKHELCHYHLHLEGKGYKHRDRDFRMLLQQVNAPRFCT PLKKKAENKKTYMYICTTCGQQYIKKRAMNPDRYRCGKCRGKIKRIFS*" /label="ydcK CDS" gene 509696..510148 /gene="ydcK" /locus_tag="BSU_04790" /old_locus_tag="BSU04790" /label="ydcK gene" promotor_-35 510154..510160 /Source="Nicolas_upshift_promotors" /id="U380" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2626 /SigmaFactorBS="gaaaaataaaaagaattttttcgtgaaaaagGTTGACGaata tggcaagcctATGTTACATTATAAAAGTCGtcacgagagataaataaaaacatttacc t" /listShort="S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1, trnS-Leu2, S169" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 510175..510194 /Source="Nicolas_upshift_promotors" /id="U380" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2626 /SigmaFactorBS="gaaaaataaaaagaattttttcgtgaaaaagGTTGACGaata tggcaagcctATGTTACATTATAAAAGTCGtcacgagagataaataaaaacatttacc t" /listShort="S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1, trnS-Leu2, S169" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 510183..510270 /Source="Nicolas_S_feature" /locus_tag="new_528616_528703" /HighExp="C30, LBGstat, Cold, UNK1, GM 25, GM 120, GM 15, Heat, T-3.40H, GM 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="SigA" /TUlongPSig="0.997" /label="S168" upshifts 510183 /Source="Nicolas_upshifts" /id="U380" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2626 /SigmaFactorBS="gaaaaataaaaagaattttttcgtgaaaaagGTTGACGaata tggcaagcctATGTTACATTATAAAAGTCGtcacgagagataaataaaaacatttacc t" /listShort="S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1, trnS-Leu2, S169" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(510215) /Source="Nicolas_upshifts" /id="D227" /incds=0 /nref=1 /ntot=28 /MaxReadThrough="2.50342" /MaxDrop="3.97305" /score="8.78044068" /energy="-9.2" /TU="NA" /idTUdmin="U381" /TUdmin=704 /isTUend="FALSE" /label="downshifts" tRNA 510271..510345 /gene="trnS-Asn" /locus_tag="BSU_tRNA_45" /product="tRNA-Asn" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Asn(GUU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnS-Asn tRNA" gene 510271..510345 /gene="trnS-Asn" /locus_tag="BSU_tRNA_45" /label="trnS-Asn gene" tRNA 510350..510440 /gene="trnS-Ser" /locus_tag="BSU_tRNA_46" /product="tRNA-Ser" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ser(GCU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnS-Ser tRNA" gene 510350..510440 /gene="trnS-Ser" /locus_tag="BSU_tRNA_46" /label="trnS-Ser gene" tRNA 510470..510541 /gene="trnS-Glu" /locus_tag="BSU_tRNA_47" /product="tRNA-Glu" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnS-Glu tRNA" gene 510470..510541 /gene="trnS-Glu" /locus_tag="BSU_tRNA_47" /label="trnS-Glu gene" tRNA 510553..510627 /gene="trnS-Gln" /locus_tag="BSU_tRNA_48" /product="tRNA-Gln" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gln(UUG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnS-Gln tRNA" gene 510553..510627 /gene="trnS-Gln" /locus_tag="BSU_tRNA_48" /label="trnS-Gln gene" tRNA 510654..510729 /gene="trnS-Lys" /locus_tag="BSU_tRNA_49" /product="tRNA-Lys" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Lys(UUU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnS-Lys tRNA" gene 510654..510729 /gene="trnS-Lys" /locus_tag="BSU_tRNA_49" /label="trnS-Lys gene" tRNA 510741..510822 /gene="trnS-Leu1" /locus_tag="BSU_tRNA_50" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Leu(UAG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnS-Leu1 tRNA" gene 510741..510822 /gene="trnS-Leu1" /locus_tag="BSU_tRNA_50" /label="trnS-Leu1 gene" downshifts 510887 /Source="Nicolas_upshifts" /id="D228" /incds=0 /nref=3 /ntot=136 /MaxReadThrough="6.94232" /MaxDrop="3.5424" /score="34.987622" /energy="-13.7" /TU="U380" /idTUdmin="U378" /TUdmin=0 /isTUend="TRUE" /label="downshifts" tRNA 510903..>510988 /gene="trnS-Leu2" /locus_tag="BSU_tRNA_51" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Leu (GAG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnS-Leu2 tRNA" gene 510903..>510988 /gene="trnS-Leu2" /locus_tag="BSU_tRNA_51" /modified_by="User" /label="trnS-Leu2 gene" SCAR 510988..510989 /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="Delta6_2" S_feature complement(<510989..511295) /Source="Nicolas_S_feature" /locus_tag="new_549923_550239_c" /HighExp="Diami, dia15, dia5, HPh, Etha, H2O2, Cold, LPh, C90, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /modified_by="User" /label="S175" downshifts 511008 /Source="Nicolas_upshifts" /id="D238" /incds=0 /nref=3 /ntot=115 /MaxReadThrough="0.144629999999999" /MaxDrop="3.58923" /score="4.45688042" /energy="-12.2" /TU="NA" /idTUdmin="U389" /TUdmin=84 /isTUend="FALSE" /label="downshifts" downshifts complement(511040) /Source="Nicolas_upshifts" /id="D239" /incds=0 /nref=3 /ntot=21 /MaxReadThrough="2.31925" /MaxDrop="3.67068" /score="-2.66780619" /energy="-18.7" /TU="NA" /idTUdmin="U391" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(511296..512315) /gene="yddN" /locus_tag="BSU_05040" /old_locus_tag="BSU05040" /EC_number="1.14.14.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9836433; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative alkanal monooxygenase" /protein_id="NP_388385.1" /db_xref="EnsemblGenomes-Gn:BSU05040" /db_xref="EnsemblGenomes-Tr:CAB12311" /db_xref="GOA:P96651" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR019949" /db_xref="InterPro:IPR036661" /db_xref="SubtiList:BG12121" /db_xref="UniProtKB/Swiss-Prot:P96651" /translation="MKKFDISVLSVAPLRQGETMKQGIDSAVSLAKAVDNMGYKRIWF AEHHNHDAYASAATVSIVQHILANTKDIRVGSGGIMLPNHSPLIVAEQFGTLETLYPN RVDLALGRAPGTDQKTADVIRRSNHNGVFFFEREVNDILRFVGDKSVQGEVRAYPGIG THVPVFVLGSSTDSAEIAAKLGLPYAFGAQFSPHSMEEALSIYRENFQPSSYLQEPYV IACINVIAAESIDEASFISASHLQVYIDIYTNNLSKLIPPTENFLESLSQFELEILHS RLGYTIMGDRETIRRELIDFQQMYHADELIVLSNIYELSKEIQSYEILKQVVDELFKK RMEQL*" /label="yddN CDS" gene complement(511296..512315) /gene="yddN" /locus_tag="BSU_05040" /old_locus_tag="BSU05040" /label="yddN gene" promotor_-10 complement(511991..512010) /Source="Nicolas_upshift_promotors" /id="U391" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig="0.999000999001" /xcortree=1980 /SigmaFactorBS="ttccccattaatcgtagcggagcaatttggaaCACTTGAAac attatatccaaaTCGTGTAGATTTGGCATTAGgacgcgcacccggaacggatcaaaaa a" /listShort="S175" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(512004) /Source="Nicolas_upshifts" /id="U391" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig="0.999000999001" /xcortree=1980 /SigmaFactorBS="ttccccattaatcgtagcggagcaatttggaaCACTTGAAac attatatccaaaTCGTGTAGATTTGGCATTAGgacgcgcacccggaacggatcaaaaa a" /listShort="S175" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(512025..512032) /Source="Nicolas_upshift_promotors" /id="U391" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig="0.999000999001" /xcortree=1980 /SigmaFactorBS="ttccccattaatcgtagcggagcaatttggaaCACTTGAAac attatatccaaaTCGTGTAGATTTGGCATTAGgacgcgcacccggaacggatcaaaaa a" /listShort="S175" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 512104..512108 /Source="Nicolas_upshift_promotors" /id="U392" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2543 /SigmaFactorBS="ttggcaacataataccccctgaacctacgcgaatgTCTTTtg tatttgctaatataTGTTGTACAATTGATACGGTtgctgcacttgcataagcgtcgtg a" /listShort="S176, lrpA, S177" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 512125..512144 /Source="Nicolas_upshift_promotors" /id="U392" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2543 /SigmaFactorBS="ttggcaacataataccccctgaacctacgcgaatgTCTTTtg tatttgctaatataTGTTGTACAATTGATACGGTtgctgcacttgcataagcgtcgtg a" /listShort="S176, lrpA, S177" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 512129 /Source="Nicolas_upshifts" /id="U392" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2543 /SigmaFactorBS="ttggcaacataataccccctgaacctacgcgaatgTCTTTtg tatttgctaatataTGTTGTACAATTGATACGGTtgctgcacttgcataagcgtcgtg a" /listShort="S176, lrpA, S177" /GFF_Attribute="listLong" /label="upshifts" S_feature 512130..512574 /Source="Nicolas_S_feature" /locus_tag="new_551074_551518" /HighExp="dia15, dia5, H2O2, G180, G135, Paraq, HPh, LBGexp, Lbexp, G150" /AntisenseName="yddN" /AntisenseCor="0.70327972625798696" /AntisenseRegPval="-40.700000000000003" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S176" CDS 512575..512985 /gene="lrpA" /locus_tag="BSU_05050" /old_locus_tag="BSU05050" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11902725, 12675791, 17223133" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11902725, 12675791, 17223133; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (Lrp/AsnC family)" /protein_id="NP_388386.1" /db_xref="EnsemblGenomes-Gn:BSU05050" /db_xref="EnsemblGenomes-Tr:CAB12312" /db_xref="GOA:P96652" /db_xref="InterPro:IPR000485" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR019887" /db_xref="InterPro:IPR019888" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12122" /db_xref="UniProtKB/Swiss-Prot:P96652" /translation="MIDEIDKKILDELSKNSRLTMKKLGEKVHLTAPATASRVVKLID NGIIKGCSIEVNQVKLGFSIHAFLNIYIEKIHHQPYLAFIETQDNYVINNYKVSGDGC YLLECKFPSNEVLDQFLNDLNKHANYKVSIVIGK*" /label="lrpA CDS" gene 512575..512985 /gene="lrpA" /locus_tag="BSU_05050" /old_locus_tag="BSU05050" /label="lrpA gene" S_feature 512986..513055 /Source="Nicolas_S_feature" /locus_tag="new_551930_551999" /HighExp="dia15, dia5, H2O2, HPh, G180, G135, LBGtran, Paraq, dia0, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S177" downshifts 513012 /Source="Nicolas_upshifts" /id="D240" /incds=0 /nref=45 /ntot=194 /MaxReadThrough="2.99689" /MaxDrop="3.6808" /score="-1.98969146" /energy="-15.7" /TU="U392" /idTUdmin="U392" /TUdmin="-350" /isTUend="FALSE" /label="downshifts" CDS complement(513108..513557) /gene="lrpB" /locus_tag="BSU_05060" /old_locus_tag="BSU05060" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11902725, 12675791, 17223133" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11902725, 12675791, 17223133; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (Lrp/AsnC family)" /protein_id="NP_388387.1" /db_xref="EnsemblGenomes-Gn:BSU05060" /db_xref="EnsemblGenomes-Tr:CAB12313" /db_xref="GOA:P96653" /db_xref="InterPro:IPR000485" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR019887" /db_xref="InterPro:IPR019888" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12123" /db_xref="UniProtKB/Swiss-Prot:P96653" /translation="MQIDSIDFQILQLLNKNARIQWKEIGEKIHMTGQAVGNRIKKME DNGIIKAYSIVVDELKMGFSFTAFVFFFMNAYMHDDLLKFIATRNEISEAHRVSGDAC YLLKVTVHSQEVLNHLLNDLLKYGNYQLYLSIKEVKKHYNTSLMSDE*" /label="lrpB CDS" gene complement(513108..513557) /gene="lrpB" /locus_tag="BSU_05060" /old_locus_tag="BSU05060" /label="lrpB gene" CDS 513672..514214 /gene="yddQ" /locus_tag="BSU_05070" /old_locus_tag="BSU05070" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_388388.1" /db_xref="EnsemblGenomes-Gn:BSU05070" /db_xref="EnsemblGenomes-Tr:CAB12314" /db_xref="GOA:P96654" /db_xref="InterPro:IPR000868" /db_xref="InterPro:IPR036380" /db_xref="SubtiList:BG12124" /db_xref="UniProtKB/Swiss-Prot:P96654" /translation="MTTALLVIDIQNDYFPNGKMALTNPEKAAQNAAKLLSHFRNTGA PVFHVQHITEGNIAHFFHPNTEGVEIHESVRPLEKETVIVKHMPNSFFNTDLNGKLQE EGVKELVVCGMMSHMCIDATVRSAVEHGYVCQVVEDACATTTLQIEDKIVPAEHVHYA FMAALNGVYATVKTTEAFLK*" /label="yddQ CDS" gene 513672..514214 /gene="yddQ" /locus_tag="BSU_05070" /old_locus_tag="BSU05070" /label="yddQ gene" promotor_-35 514687..514691 /Source="Nicolas_upshift_promotors" /id="U393" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=2688 /SigmaFactorBS="agtcaaagagttaaaacacttttttttatcTATGTattcgaa cactgctgaTATTATACACTTAACTCTGTcgatctaagacaaataaaaaaagaaagtg a" /listShort="yddR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 514708..514727 /Source="Nicolas_upshift_promotors" /id="U393" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=2688 /SigmaFactorBS="agtcaaagagttaaaacacttttttttatcTATGTattcgaa cactgctgaTATTATACACTTAACTCTGTcgatctaagacaaataaaaaaagaaagtg a" /listShort="yddR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 514717 /Source="Nicolas_upshifts" /id="U393" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=2688 /SigmaFactorBS="agtcaaagagttaaaacacttttttttatcTATGTattcgaa cactgctgaTATTATACACTTAACTCTGTcgatctaagacaaataaaaaaagaaagtg a" /listShort="yddR" /GFF_Attribute="listLong" /label="upshifts" CDS 514767..515531 /gene="yddR" /locus_tag="BSU_05080" /old_locus_tag="BSU05080" /EC_number="3.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent hydrolase" /protein_id="NP_388389.1" /db_xref="EnsemblGenomes-Gn:BSU05080" /db_xref="EnsemblGenomes-Tr:CAB12315" /db_xref="GOA:P96655" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG12125" /db_xref="UniProtKB/Swiss-Prot:P96655" /translation="MNITQIRNATIVVKYANKKFLIDPMLAEKGTYATFPETIRQDLF NPLVSLPTSIDNILDGVDAVIVTHLHLDHFDDVAKNVLPKNIKMFVQNEADAKEVKAS GFKNVEVLHQDTVFEGIQLVKTKGEHGRGEELLNLMGDVCGLVFKHPSEKVLYVAGDT VWYDAIEDEIHTHQPEIIVVNGGDNQRLDLGSLIMGKEDIYEVHKAAPHAKIISVHME AVNHWTLSREELKNFSKEKGFSSNILVPEDGESYTF*" /label="yddR CDS" gene 514767..515531 /gene="yddR" /locus_tag="BSU_05080" /old_locus_tag="BSU05080" /label="yddR gene" CDS 515725..517035 /gene="yddS" /locus_tag="BSU_05090" /old_locus_tag="BSU05090" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388390.1" /db_xref="EnsemblGenomes-Gn:BSU05090" /db_xref="EnsemblGenomes-Tr:CAB12316" /db_xref="GOA:P96656" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12126" /db_xref="UniProtKB/Swiss-Prot:P96656" /translation="MVMTKKDTNISTQQPLWLQGYIDSPEKQNQLYKKTLKILIFSQI FGGAGLGAGITVGALLAQDMIGSENVAGIPTALFTFGSAVAALLIGASSQRFGRRAGL AGGFLIGGLGAIGVIIAALINSVALLFVSLLIYGAGMASNLQVRYAGTDLANEKQRAT AASMALVSTTLGAVVGPNLVNTMGEFADSIGVPNLAGPFIMSGAAFIIAGIILLIFLR PDPLFVSTAIANAEKKDDKVQIGGSLKNPAIDKKGIMVGAVIMILAQLIMTAIMTMTP VHMGHHGHGLSEVGLVIGLHIAAMYLPSPLTGLLVDKFGRTTMAIASGATLLAAGLVA AIAPADSLSLLILALVLLGVGWNFGLLTGTALIIDSTHPSLRAKTQGTFDVLLALSGA AGGALSGMVVAHSSYTILSISGAVLSLLLIPVVIWYFRRIQEKA*" /label="yddS CDS" gene 515725..517035 /gene="yddS" /locus_tag="BSU_05090" /old_locus_tag="BSU05090" /label="yddS gene" S_feature 517058..517617 /Source="Nicolas_S_feature" /locus_tag="new_556002_556561" /HighExp="S8, C30, Cold, BMM, C90, GM 25, MG 15, M/G, LPh, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S178" CDS 517618..517794 /gene="ydzM" /locus_tag="BSU_05099" /old_locus_tag="BSU05099" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="conserved phage protein of unknown function" /protein_id="YP_003097682.1" /db_xref="EnsemblGenomes-Gn:BSU05099" /db_xref="EnsemblGenomes-Tr:CAX52553" /db_xref="GOA:Q9K3A9" /db_xref="UniProtKB/Swiss-Prot:Q9K3A9" /translation="MNNKKNIFDIVMYIIFGVLSLFLVAKTDYGTGVLVFVAILYLAV IAYKIKQVFSNSDS*" /label="ydzM CDS" gene 517618..517794 /gene="ydzM" /locus_tag="BSU_05099" /old_locus_tag="BSU05099" /label="ydzM gene" CDS 517819..518505 /gene="yddT" /locus_tag="BSU_05100" /old_locus_tag="BSU05100" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative exported phage protein" /protein_id="NP_388391.1" /db_xref="EnsemblGenomes-Gn:BSU05100" /db_xref="EnsemblGenomes-Tr:CAB12317" /db_xref="SubtiList:BG12127" /db_xref="UniProtKB/Swiss-Prot:P96657" /translation="MRKKRVITCVMAASLTLGSLLPAGYASAKEDSKTTPSYEELALH YKMKSEKISSNGKLVEIEYVSGNETHKVQMNGNNHTVKVDGIEQKGLNFEYDENVAKR TNYENNNLKSNEFTTQAAKPKKGYHYVGTLSGHTKAAKNALSVTMSLVGIVPGLGWGS KAATILFSYWAKEQIPDAYYKYDLYEKGAMTDSWYQYATVQFFEDKAHKKKMGKPWTS TPAKVDLPNS*" /label="yddT CDS" gene 517819..518505 /gene="yddT" /locus_tag="BSU_05100" /old_locus_tag="BSU05100" /label="yddT gene" promotor_-35 518847..518851 /Source="Nicolas_upshift_promotors" /id="U394" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.383616383616384" /psig="0.999000999001" /xcortree=2778 /SigmaFactorBS="gaaaggtttaagattagatattgaaaaattttaTATATtttc aataaaatacTGGTACTATAATAAATGTATacagattgtatggagatgtaattaatta a" /listShort="ydzN, ydeA" /listLong="S179, cspC" /label="promotor_-35" promotor_-10 518866..518885 /Source="Nicolas_upshift_promotors" /id="U394" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.383616383616384" /psig="0.999000999001" /xcortree=2778 /SigmaFactorBS="gaaaggtttaagattagatattgaaaaattttaTATATtttc aataaaatacTGGTACTATAATAAATGTATacagattgtatggagatgtaattaatta a" /listShort="ydzN, ydeA" /listLong="S179, cspC" /label="promotor_-10" upshifts 518874 /Source="Nicolas_upshifts" /id="U394" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.383616383616384" /psig="0.999000999001" /xcortree=2778 /SigmaFactorBS="gaaaggtttaagattagatattgaaaaattttaTATATtttc aataaaatacTGGTACTATAATAAATGTATacagattgtatggagatgtaattaatta a" /listShort="ydzN, ydeA" /listLong="S179, cspC" /label="upshifts" Polymorphism join(518921,518923) /Source="geneious" /ID="SNP_BsDelta6_557866_557865" /Polymorphism_Type="Insertion (tandem repeat)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=0 /Amino_Acid_Change /CDS_Position /Change="(T)5 -> (T)6" /Codon_Change /Coverage=35 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides /Variant_Nucleotides="T" /Variant_P_Value="3.2e-123" /Variant_Raw_Frequency=35 /comment="ydzN_translation_signal_variant" /modified_by="User" / /label="Polymorphism_Delta6" CDS 518930..519115 /gene="ydzN" /locus_tag="BSU_05109" /old_locus_tag="BSU05109" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097683.1" /db_xref="EnsemblGenomes-Gn:BSU05109" /db_xref="EnsemblGenomes-Tr:CAX52554" /db_xref="GOA:C0H3V7" /db_xref="UniProtKB/Swiss-Prot:C0H3V7" /translation="MRWSKWFNVFCIVALGSIYGYKLFTNQEVSTTRLIIASVIVLWN IVGLFSKESVKQAQQAN*" /label="ydzN CDS" gene 518930..519115 /gene="ydzN" /locus_tag="BSU_05109" /old_locus_tag="BSU05109" /label="ydzN gene" downshifts 519114 /Source="Nicolas_upshifts" /id="D241" /incds=0 /nref=9 /ntot=125 /MaxReadThrough="3.39785" /MaxDrop="3.7067" /score="-6.31330934" /energy="-12.8" /TU="U394" /idTUdmin="U394" /TUdmin="-1068" /isTUend="FALSE" /label="downshifts" CDS 519465..520058 /gene="sufLC" /locus_tag="BSU_05110" /old_locus_tag="BSU05110" /experiment="publication(s) with functional evidences, PMID:24330391" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 24330391; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glyoxalase III homolog, deglycase" /protein_id="NP_388392.1" /db_xref="EnsemblGenomes-Gn:BSU05110" /db_xref="EnsemblGenomes-Tr:CAB12318" /db_xref="GOA:P96658" /db_xref="InterPro:IPR002818" /db_xref="InterPro:IPR029062" /db_xref="PDB:3F5D" /db_xref="SubtiList:BG12128" /db_xref="UniProtKB/Swiss-Prot:P96658" /translation="MKKALFLILDQYADWEGVYLASALNQREDWSVHTVSLDPIVSSI GGFKTSVDYIIGLEPANFNLLVMIGGDSWSNDNKKLLHFVKTAFQKNIPIAAICGAVD FLAKNGLLNNHSHTGNFVYLWKDYKQYKPISSFVEKQAVRDKNLVTANGTAPIEFTNL ILEMIDFDTPENIEKMMYMNRYGFYHFCDKYGNPFVD*" /label="sufLC CDS" gene 519465..520058 /gene="sufLC" /locus_tag="BSU_05110" /old_locus_tag="BSU05110" /label="sufLC gene" promotor_-35 520171..520178 /Source="Nicolas_upshift_promotors" /id="U395" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.561438561438561" /psig=1 /xcortree=3090 /SigmaFactorBS="aagtttaacaaataatgccatcaatattAATTTGCAgttatt tccgattCCTGATATAATAAAGAAGAAttatttttgttcggtgtaaaggatagtatga a" /listShort="S179, cspC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 520192..520211 /Source="Nicolas_upshift_promotors" /id="U395" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.561438561438561" /psig=1 /xcortree=3090 /SigmaFactorBS="aagtttaacaaataatgccatcaatattAATTTGCAgttatt tccgattCCTGATATAATAAAGAAGAAttatttttgttcggtgtaaaggatagtatga a" /listShort="S179, cspC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 520203..520320 /Source="Nicolas_S_feature" /locus_tag="new_559146_559263" /HighExp="B60, LoTm, T5.0H, T3.30H, M9-stat, BI, BC, C90, T3.0H, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.999" /label="S179" upshifts 520203 /Source="Nicolas_upshifts" /id="U395" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.561438561438561" /psig=1 /xcortree=3090 /SigmaFactorBS="aagtttaacaaataatgccatcaatattAATTTGCAgttatt tccgattCCTGATATAATAAAGAAGAAttatttttgttcggtgtaaaggatagtatga a" /listShort="S179, cspC" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(520238) /Source="Nicolas_upshifts" /id="D242" /incds=0 /nref=10 /ntot=93 /MaxReadThrough="1.86628" /MaxDrop="4.19111" /score="25.1917407" /energy="-12.9" /TU="NA" /idTUdmin="U396" /TUdmin=328 /isTUend="FALSE" /label="downshifts" CDS 520321..520521 /gene="cspC" /locus_tag="BSU_05120" /old_locus_tag="BSU05120" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9379903, 9914312, 9920884, 10517332, 11591689, 12427936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9379903, 9914312, 9920884, 10517332, 11591689, 12427936; Product type f : factor" /codon_start=1 /transl_table=11 /product="cold-shock protein" /protein_id="NP_388393.1" /db_xref="EnsemblGenomes-Gn:BSU05120" /db_xref="EnsemblGenomes-Tr:CAB12319" /db_xref="GOA:P39158" /db_xref="InterPro:IPR002059" /db_xref="InterPro:IPR011129" /db_xref="InterPro:IPR012156" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR019844" /db_xref="SubtiList:BG11024" /db_xref="UniProtKB/Swiss-Prot:P39158" /translation="MEQGTVKWFNAEKGFGFIERENGDDVFVHFSAIQSDGFKSLDEG QKVSFDVEQGARGAQAANVQKA*" /label="cspC CDS" gene 520321..520521 /gene="cspC" /locus_tag="BSU_05120" /old_locus_tag="BSU05120" /label="cspC gene" S_feature complement(520419..521207) /Source="Nicolas_S_feature" /locus_tag="new_559362_560150_c" /HighExp="LoTm, B60, Cold, M9-stat, LPhT, B36, Sw, BC, S8, Salt" /AntisenseName="cspC" /AntisenseCor="0.39074308987975698" /AntisenseRegPval="-10.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S180" downshifts 520424 /Source="Nicolas_upshifts" /id="D243" /incds=1 /nref=19 /ntot=179 /MaxReadThrough="8.05368" /MaxDrop="3.4464" /score="27.3387234" /energy="-11.3" /TU="U395" /idTUdmin="U394" /TUdmin=242 /isTUend="FALSE" /label="downshifts" downshifts 520525 /Source="Nicolas_upshifts" /id="D244" /incds=0 /nref=65 /ntot=246 /MaxReadThrough="5.78621" /MaxDrop="5.83905" /score="27.3387234" /energy="-11.3" /TU="U395" /idTUdmin="U394" /TUdmin=343 /isTUend="FALSE" /label="downshifts" misc_RNA complement(520589..520667) /gene="sncZ" /locus_tag="BSU_misc_RNA_66" /product="putative small conserved untranslated RNA" /experiment="publication(s) with functional evidences, PMID:20525796" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20525796; Product type n: RNA" /label="sncZ RNA" gene complement(520589..520667) /gene="sncZ" /locus_tag="BSU_misc_RNA_66" /label="sncZ gene" CDS complement(521208..521669) /gene="cdnL" /locus_tag="BSU_05130" /old_locus_tag="BSU05130" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 26849219; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator for repair and outgrowth of heat damaged spores" /protein_id="NP_388394.1" /db_xref="EnsemblGenomes-Gn:BSU05130" /db_xref="EnsemblGenomes-Tr:CAB12320" /db_xref="InterPro:IPR003711" /db_xref="InterPro:IPR036101" /db_xref="SubtiList:BG12129" /db_xref="UniProtKB/Swiss-Prot:P96659" /translation="MFQIGDNIVYPMHGAGIIEAIEEKEFLEEKQQYYVIRMSISNMT VMIPTSKILSSNIRPVTDILALKHIMHIFQHGESDRLLPWKQRYKINTDKIKTGEIQE GAEVVRDLMRMKKEKALNASEKKMLDNAYEFLISELEVIKGITEKQIKSFG*" /label="cdnL CDS" gene complement(521208..521669) /gene="cdnL" /locus_tag="BSU_05130" /old_locus_tag="BSU05130" /label="cdnL gene" S_feature 521678..522223 /Source="Nicolas_S_feature" /locus_tag="new_560621_561166" /HighExp="Cold, G135, S8, G180, LoTm, S7, G150, HPh, Paraq, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S181" upshifts complement(521721) /Source="Nicolas_upshifts" /id="U396" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=427 /SigmaFactorBS="ttcaaaaaagtTATTGACAtcaaaaattcgatcaTGTTATTA TTAAAATTTTGAtattacacctccatatatggtaatcttaagaaggataccatatatg g" /listShort="ydeB, S180" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(521728..521747) /Source="Nicolas_upshift_promotors" /id="U396" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=427 /SigmaFactorBS="ttcaaaaaagtTATTGACAtcaaaaattcgatcaTGTTATTA TTAAAATTTTGAtattacacctccatatatggtaatcttaagaaggataccatatatg g" /listShort="ydeB, S180" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(521763..521770) /Source="Nicolas_upshift_promotors" /id="U396" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=427 /SigmaFactorBS="ttcaaaaaagtTATTGACAtcaaaaattcgatcaTGTTATTA TTAAAATTTTGAtattacacctccatatatggtaatcttaagaaggataccatatatg g" /listShort="ydeB, S180" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 522190 /Source="Nicolas_upshifts" /id="D245" /incds=0 /nref=7 /ntot=141 /MaxReadThrough="0.289110000000001" /MaxDrop="4.3701" /score="26.1823933" /energy="-9.5" /TU="NA" /idTUdmin="U395" /TUdmin=864 /isTUend="FALSE" /label="downshifts" CDS complement(522237..522473) /gene="ydzE" /locus_tag="BSU_05140" /old_locus_tag="BSU05140" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388395.1" /db_xref="EnsemblGenomes-Gn:BSU05140" /db_xref="EnsemblGenomes-Tr:CAB12321" /db_xref="GOA:O31493" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG12808" /db_xref="UniProtKB/Swiss-Prot:O31493" /translation="MYLGIVSTACAFLLWNHGLQLLNASSGGLFFFFQPLVGTLLGWI LLGEQIGGTFWIGSFLILSGVLLVIKEKEKEVKS*" /label="ydzE CDS" gene complement(522237..522473) /gene="ydzE" /locus_tag="BSU_05140" /old_locus_tag="BSU05140" /label="ydzE gene" CDS complement(522571..523446) /gene="ydeC" /locus_tag="BSU_05150" /old_locus_tag="BSU05150" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10704478; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (AraC/XylS family)" /protein_id="NP_388396.1" /db_xref="EnsemblGenomes-Gn:BSU05150" /db_xref="EnsemblGenomes-Tr:CAB12322" /db_xref="GOA:P96660" /db_xref="InterPro:IPR003313" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR018060" /db_xref="InterPro:IPR018062" /db_xref="InterPro:IPR020449" /db_xref="SubtiList:BG12130" /db_xref="UniProtKB/Swiss-Prot:P96660" /translation="MKNFVIDQNLKELTEHRTVELPVACYKTTINQNINGYIPLHWHD EIQFVLILKGIALFQINEEKIEVHEGDGLFINSGYLHMAEEKEGSDCTYICLNVSPHF VLSQELYSSYVQPYMFSTNLPYLFLAGNQQWAKNILDAVKKINQLIQQKTSLYEIDIT MQLTLMWKNLVVNGFQLEYDQSEMIKSHRMKQMLNWIHLHYVEKITLEDIAKAGQLSR SECCRYFKRMLNKTPLRYVMDYRIQKSLLLLQHPESNVTEVSYQVGFNSTSYFISKFQ QAMNMTPLSYKKMNS*" /label="ydeC CDS" gene complement(522571..523446) /gene="ydeC" /locus_tag="BSU_05150" /old_locus_tag="BSU05150" /label="ydeC gene" CDS 523559..524518 /gene="ydeD" /locus_tag="BSU_05160" /old_locus_tag="BSU05160" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388397.1" /db_xref="EnsemblGenomes-Gn:BSU05160" /db_xref="EnsemblGenomes-Tr:CAB12323" /db_xref="GOA:P96661" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG12131" /db_xref="UniProtKB/Swiss-Prot:P96661" /translation="MNTSNRRMGLFYVITGATCWGIGGTVAKKLFQEYQIDVNWLVTT RLLTAGMLLLMLQLFRKDRSQVIEVWKHKASAGQLLIFGLLGMLAVQYTYMASIQHGN AAVATLLQYLSPVIVIIYTLLRKQTVLTKQDIITVVLALVGCFFLLTNGSMSQLSVPA AAVVWGVLSGFAAAFYTLYAVGLLNKFDSLVVVGWAMIIGGFALGFIHPPWQLDFQRL TAEAYAYILFVILFGTMIAFWFFIKSLESLSPKETSLLGSLEPLSAVVTTVVWLKAPF GSFQWIGAICIIGITLILALHKEPSMESEKSILKIRNHANRDI*" /label="ydeD CDS" gene 523559..524518 /gene="ydeD" /locus_tag="BSU_05160" /old_locus_tag="BSU05160" /label="ydeD gene" upshifts complement(523580) /Source="Nicolas_upshifts" /id="U397" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.555444555444555" /psig="0.808191808191808" /xcortree=1969 /SigmaFactorBS="tggctactgtgcctccaatcccccaacatgtcgccccTGTGA TAACATAGAACAATCccattcttctattggaagtattcatacatgactcctcactaat a" /listShort="ydeC" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(523584..523603) /Source="Nicolas_upshift_promotors" /id="U397" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.555444555444555" /psig="0.808191808191808" /xcortree=1969 /SigmaFactorBS="tggctactgtgcctccaatcccccaacatgtcgccccTGTGA TAACATAGAACAATCccattcttctattggaagtattcatacatgactcctcactaat a" /listShort="ydeC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(524671..525543) /gene="ydeE" /locus_tag="BSU_05170" /old_locus_tag="BSU05170" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (AraC/XylS family)" /protein_id="NP_388398.1" /db_xref="EnsemblGenomes-Gn:BSU05170" /db_xref="EnsemblGenomes-Tr:CAB12324" /db_xref="GOA:P96662" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR010499" /db_xref="InterPro:IPR011256" /db_xref="InterPro:IPR018060" /db_xref="InterPro:IPR018062" /db_xref="InterPro:IPR020449" /db_xref="InterPro:IPR029442" /db_xref="SubtiList:BG12132" /db_xref="UniProtKB/Swiss-Prot:P96662" /translation="MDLLKSMNRALKYIEENLTNDIDFQEAAKLAFCSEYHFKRMFSF LAGISLSEYIRRRRLTLAAFELKDSNVKVIDIAIKYGYNSPDSFARAFQNLHGINPSK ARFNGHSLKAYPRMTFQLTIKGGNEMNYRIEEKEAFRIVGIKKRVPIIFKGINPEIAS MWESLDEKAINKLKELSNVAPSGLISASTNFSEGRTEENGELDHYIGAATTKRCPDNF SRLEVPASTWAVFESIGPFPDTLQEVWGRIYSEWFPSSNYEQIEGPEILWNEHKDVTS PSFKSEIWIPITKK*" /label="ydeE CDS" gene complement(524671..525543) /gene="ydeE" /locus_tag="BSU_05170" /old_locus_tag="BSU05170" /label="ydeE gene" promotor_-10 complement(525636..525641) /Source="Nicolas_upshift_promotors" /id="U398" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.380619380619381" /psig="0.432567432567433" /xcortree=1464 /SigmaFactorBS="cttttattgatgcctttttatgaacagcatgcttcaataaaa cctgtacaaatacaagtgaatcACtTACTTTatttcatataagtcatcctgcaaaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(525643..525644) /Source="Nicolas_upshift_promotors" /id="U398" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.380619380619381" /psig="0.432567432567433" /xcortree=1464 /SigmaFactorBS="cttttattgatgcctttttatgaacagcatgcttcaataaaa cctgtacaaatacaagtgaatcACtTACTTTatttcatataagtcatcctgcaaaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(525648) /Source="Nicolas_upshifts" /id="U398" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.380619380619381" /psig="0.432567432567433" /xcortree=1464 /SigmaFactorBS="cttttattgatgcctttttatgaacagcatgcttcaataaaa cctgtacaaatacaagtgaatcACtTACTTTatttcatataagtcatcctgcaaaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 525717..525723 /Source="Nicolas_upshift_promotors" /id="U399" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.408591408591409" /psig="0.98101898101898" /xcortree=1860 /SigmaFactorBS="attgaagcatgctgttcataaaaaggcatcaataaaagaaag ttatAATTGTCttataaacggcacATTCATATAATTGAGTGAAAaaggatgcgtatca t" /listShort="ydeF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 525731 /Source="Nicolas_upshifts" /id="U399" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.408591408591409" /psig="0.98101898101898" /xcortree=1860 /SigmaFactorBS="attgaagcatgctgttcataaaaaggcatcaataaaagaaag ttatAATTGTCttataaacggcacATTCATATAATTGAGTGAAAaaggatgcgtatca t" /listShort="ydeF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 525737..525756 /Source="Nicolas_upshift_promotors" /id="U399" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.408591408591409" /psig="0.98101898101898" /xcortree=1860 /SigmaFactorBS="attgaagcatgctgttcataaaaaggcatcaataaaagaaag ttatAATTGTCttataaacggcacATTCATATAATTGAGTGAAAaaggatgcgtatca t" /listShort="ydeF" /GFF_Attribute="listLong" /label="promotor_-10" CDS 525770..527158 /gene="ydeF" /locus_tag="BSU_05180" /old_locus_tag="BSU05180" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15223311, 28348215; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative PLP-dependent transcriptional regulator" /protein_id="NP_388399.2" /db_xref="EnsemblGenomes-Gn:BSU05180" /db_xref="EnsemblGenomes-Tr:CAB12325" /db_xref="GOA:P96663" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12133" /db_xref="UniProtKB/Swiss-Prot:P96663" /translation="MPINSFENYPMSWKPSIDKAEKPIYKALAGQLEQDILNGVLLPG TKLPPQRELADYLDLNVSTISKAFKVCELKGLLSATVGSGTFVSYDALSNAYLLEDTK PTHLIEMGAILPDHASYEPLLYQLKNMVHEEDYEKWFSYGRAGESLWQKDAAVKLIQR GGFETSVDHILFANGGQNAIAATLASLCKPGDRIGVDHHTYPGLKTVASLLSVQIVPI KSENDEMSPESLEYACKNENIKGLYLIPDYHNPTTSFMSVENRRMVADIVKKYNLFVI EDASYHLLNKNPLPALASFAPQQVIHIASLSKSLAPGLRLAYVAVPRQYKEPISKALY NLNITVSPLLAELTARTIVSNQFEVLIESHREQTIRRNQLVNRYVAGYTCLGVETGIF RWLLLPGKMSGAEFEELAARLGVQVYAAERFVVGNSCPERAVRVSVCAPKTLEELEQG LMILRRLLDDLT*" /label="ydeF CDS" gene 525770..527158 /gene="ydeF" /locus_tag="BSU_05180" /old_locus_tag="BSU05180" /label="ydeF gene" downshifts 527134 /Source="Nicolas_upshifts" /id="D246" /incds=0 /nref=2 /ntot=61 /MaxReadThrough="0.91547" /MaxDrop="3.65963" /score="12.298375" /energy="-12.2" /TU="NA" /idTUdmin="U399" /TUdmin=176 /isTUend="FALSE" /label="downshifts" CDS 527268..528560 /gene="ydeG" /locus_tag="BSU_05190" /old_locus_tag="BSU05190" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388400.1" /db_xref="EnsemblGenomes-Gn:BSU05190" /db_xref="EnsemblGenomes-Tr:CAB12326" /db_xref="GOA:P96664" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12134" /db_xref="UniProtKB/Swiss-Prot:P96664" /translation="MMLDKDSVKAIDVQTASLQSYISSPEKQKSLYKRTLFVVSISQI FGGAGLAAGVTVGALIAQQMLGTDAFAGLPSALFTLGSAGSALIVGRLSQRYGRRTGL SAGFMIGGLGAIGVIMAAIINSIFLLFISLLIYGAGTATNLQARYAGTDLANHKQRAT AVSITMVFTTFGAVAGPSLVNVMGDFALSIGVPSLAGPFILAAAAYMLAGVVLFIMLR PDPLVIARTIEAANEEPGDKGHLAATEHTENKKGIIVGATVMVLTQIVMVAIMTMTPV HMRHHGHDLGAVGLVIGFHIGAMYLPSLVTGVLVDRLGRTAMAISSGTTLLLAGVIAA FAPGESMILLVIALSLLGLGWNFGLISGTALIVDSTDTATRAKTQGTVDVLIALSGAA GGALSGMIVAGSSYLALSLIGGILSLLLIPVVVWSRGR*" /label="ydeG CDS" gene 527268..528560 /gene="ydeG" /locus_tag="BSU_05190" /old_locus_tag="BSU05190" /label="ydeG gene" promotor_-35 528569..528575 /Source="Nicolas_upshift_promotors" /id="U400" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.737262737262737" /psig=1 /xcortree=2927 /SigmaFactorBS="gtggtatggtctaggggccgctaaagggtaggATTGTTTaat ttacattaattTGTTATATTGTTAGATAAAGtatattgcagcatctaatattctaacg a" /listShort="S182, ydeH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 528590..528609 /Source="Nicolas_upshift_promotors" /id="U400" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.737262737262737" /psig=1 /xcortree=2927 /SigmaFactorBS="gtggtatggtctaggggccgctaaagggtaggATTGTTTaat ttacattaattTGTTATATTGTTAGATAAAGtatattgcagcatctaatattctaacg a" /listShort="S182, ydeH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 528597 /Source="Nicolas_upshifts" /id="U400" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.737262737262737" /psig=1 /xcortree=2927 /SigmaFactorBS="gtggtatggtctaggggccgctaaagggtaggATTGTTTaat ttacattaattTGTTATATTGTTAGATAAAGtatattgcagcatctaatattctaacg a" /listShort="S182, ydeH" /GFF_Attribute="listLong" /label="upshifts" S_feature 528608..528718 /Source="Nicolas_S_feature" /locus_tag="new_567551_567661" /HighExp="LoTm, T4.0H, T3.30H, T2.30H, T3.0H, T2.0H, T1.30H, T5.0H, T1.0H, T-0.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S182" CDS 528719..529165 /gene="ydeH" /locus_tag="BSU_05200" /old_locus_tag="BSU05200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388401.1" /db_xref="EnsemblGenomes-Gn:BSU05200" /db_xref="EnsemblGenomes-Tr:CAB12327" /db_xref="GOA:P96665" /db_xref="SubtiList:BG12135" /db_xref="UniProtKB/Swiss-Prot:P96665" /translation="MNHIKWLSDLKKAGLLALGKGVITLLKRFSLVIVTLMMSIVVVL AAAKESPGDHVISFDEPIILMISIGIVVFLLIPPLVMSFFGNLVVRIISGVYQCFIVF TFLGLIPIGFLIPNGFLTILVSIAGTLVSIASVAVTLCIGKNKKDI*" /label="ydeH CDS" gene 528719..529165 /gene="ydeH" /locus_tag="BSU_05200" /old_locus_tag="BSU05200" /label="ydeH gene" downshifts 529194 /Source="Nicolas_upshifts" /id="D247" /incds=0 /nref=200 /ntot=251 /MaxReadThrough="2.56495" /MaxDrop="6.50538" /score="-1.7193297" /energy="-4.5" /TU="NA" /idTUdmin="U400" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" promotor_-35 529245..529252 /Source="Nicolas_upshift_promotors" /id="U401" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.921078921078921" /psig="0.99100899100899" /xcortree=2390 /SigmaFactorBS="tacaaaaagagaaggcttgtgggccttctttttttgtTGTTG CATcatccccactttgaGCTTAATCTATTGAATAATAagagaaggaacctatagaaga a" /listShort="ydeI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 529267..529286 /Source="Nicolas_upshift_promotors" /id="U401" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.921078921078921" /psig="0.99100899100899" /xcortree=2390 /SigmaFactorBS="tacaaaaagagaaggcttgtgggccttctttttttgtTGTTG CATcatccccactttgaGCTTAATCTATTGAATAATAagagaaggaacctatagaaga a" /listShort="ydeI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 529268 /Source="Nicolas_upshifts" /id="U401" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.921078921078921" /psig="0.99100899100899" /xcortree=2390 /SigmaFactorBS="tacaaaaagagaaggcttgtgggccttctttttttgtTGTTG CATcatccccactttgaGCTTAATCTATTGAATAATAagagaaggaacctatagaaga a" /listShort="ydeI" /GFF_Attribute="listLong" /label="upshifts" CDS 529402..529995 /gene="ydeI" /locus_tag="BSU_05210" /old_locus_tag="BSU05210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16390439" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388402.1" /db_xref="EnsemblGenomes-Gn:BSU05210" /db_xref="EnsemblGenomes-Tr:CAB12328" /db_xref="InterPro:IPR014922" /db_xref="InterPro:IPR016786" /db_xref="SubtiList:BG12136" /db_xref="UniProtKB/Swiss-Prot:P96666" /translation="MTNSRTNPKVDEFLSKAKKWKEEFEKLRTIILDCELTEDFKWMH PCYTYHNKNIVLIHGFKEYCALLFHKGVLLQDTDGILIQQTENVQAARQIRFTNVQEI NELENILKAYIHEAIEVEKAGLKVDVNKNIELNIPEELQNKFDEIPALKIAFEALTPG RQRAYTLYFSQAKQSKTRESRVEKYVQKILDGKGLKD*" /label="ydeI CDS" gene 529402..529995 /gene="ydeI" /locus_tag="BSU_05210" /old_locus_tag="BSU05210" /label="ydeI gene" downshifts 530038 /Source="Nicolas_upshifts" /id="D248" /incds=0 /nref=2 /ntot=40 /MaxReadThrough="1.63432" /MaxDrop="2.96785" /score="2.93671425" /energy="-6.9" /TU="NA" /idTUdmin="U401" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(530114) /Source="Nicolas_upshifts" /id="D249" /incds=0 /nref=1 /ntot=64 /MaxReadThrough="2.19009" /MaxDrop="2.9369" /score="-1.28013562" /energy="-6.9" /TU="NA" /idTUdmin="U403" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 530127..530134 /Source="Nicolas_upshift_promotors" /id="U402" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.707292707292707" /psig="0.996003996003996" /xcortree=378 /SigmaFactorBS="tcttaggacaacattcacttactgctgaaatgcttctaaCAT TGTATgccactagacagcgTTATAAAATATTAATGCAACacctagaaatctatccaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 530148 /Source="Nicolas_upshifts" /id="U402" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.707292707292707" /psig="0.996003996003996" /xcortree=378 /SigmaFactorBS="tcttaggacaacattcacttactgctgaaatgcttctaaCAT TGTATgccactagacagcgTTATAAAATATTAATGCAACacctagaaatctatccaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 530149..530168 /Source="Nicolas_upshift_promotors" /id="U402" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.707292707292707" /psig="0.996003996003996" /xcortree=378 /SigmaFactorBS="tcttaggacaacattcacttactgctgaaatgcttctaaCAT TGTATgccactagacagcgTTATAAAATATTAATGCAACacctagaaatctatccaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(530347..531006) /gene="ydeJ" /locus_tag="BSU_05220" /old_locus_tag="BSU05220" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_388403.1" /db_xref="EnsemblGenomes-Gn:BSU05220" /db_xref="EnsemblGenomes-Tr:CAB12329" /db_xref="GOA:P96667" /db_xref="SubtiList:BG12137" /db_xref="UniProtKB/Swiss-Prot:P96667" /translation="MKKRRKICYCNTALLLMILLAGCTDSKDGEAQQPSNQASAVQTD EKHTEPEESTKIRKDEAEPITESEESATKAANDTSSAEEKSKEDNVLAAYSSEKIEYA RVWLQLGPNQEIDELNVRHIAAGEPINPNDDTSASYPENVTQLAGSRLVDGSVTYHGN GDGTIHVYNVPLRWDSADDIEKGVMREVTESIIKNRKTVYVDTGDDEKIKRLIDIMMI H*" /label="ydeJ CDS" gene complement(530347..531006) /gene="ydeJ" /locus_tag="BSU_05220" /old_locus_tag="BSU05220" /label="ydeJ gene" promotor_-10 complement(531055..531074) /Source="Nicolas_upshift_promotors" /id="U403" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.987012987012987" /psig="0.997002997002997" /xcortree=3174 /SigmaFactorBS="agatcgtttcctcttcttaaacagttttcaaTATCATcctat ctattcCATGGTAATATTTAGATACAtaaacttatatatgaagctgacctgaattaat a" /listShort="ydeJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(531062) /Source="Nicolas_upshifts" /id="U403" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.987012987012987" /psig="0.997002997002997" /xcortree=3174 /SigmaFactorBS="agatcgtttcctcttcttaaacagttttcaaTATCATcctat ctattcCATGGTAATATTTAGATACAtaaacttatatatgaagctgacctgaattaat a" /listShort="ydeJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(531086..531091) /Source="Nicolas_upshift_promotors" /id="U403" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.987012987012987" /psig="0.997002997002997" /xcortree=3174 /SigmaFactorBS="agatcgtttcctcttcttaaacagttttcaaTATCATcctat ctattcCATGGTAATATTTAGATACAtaaacttatatatgaagctgacctgaattaat a" /listShort="ydeJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(531428..532291) /gene="ydeK" /locus_tag="BSU_05230" /old_locus_tag="BSU05230" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388404.1" /db_xref="EnsemblGenomes-Gn:BSU05230" /db_xref="EnsemblGenomes-Tr:CAB12330" /db_xref="GOA:P96668" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG12138" /db_xref="UniProtKB/Swiss-Prot:P96668" /translation="MNKTTNGWINGFIGVLIFSGSLPATRLAVSDFDPLFLTVCRAAI AGVLAGGLLLIFRQQHPAKRDLISLLVVAFGVVIGFPLLTALALQHVTSAHAIVFIGL LPLATAVFGVLRGGERPRPVFWIFSAAGSLLVAGFALIQGGGSSPLGDAYMLASIVVC GLGYAEGAKLSRRLGNWQVISWALVLSLPLMLPLSFFFTPDSWSAIGVPALLSLAYVS LFSMLIGFVFWYRGLAQGGIAAVGQLQLLQPFFGLLLASVILHEKVGWALVAVNIAVI MCVAAARRFAK*" /label="ydeK CDS" gene complement(531428..532291) /gene="ydeK" /locus_tag="BSU_05230" /old_locus_tag="BSU05230" /label="ydeK gene" promotor_-35 532334..532340 /Source="Nicolas_upshift_promotors" /id="U404" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.548451548451548" /psig="0.97002997002997" /xcortree=639 /SigmaFactorBS="ctttcttgttcattgtctgtatttTCTTAACaaaaccagcag ctaAGGATTACAATGACTATAAActggaattggccttttataaacagccagttttcat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 532355..532374 /Source="Nicolas_upshift_promotors" /id="U404" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.548451548451548" /psig="0.97002997002997" /xcortree=639 /SigmaFactorBS="ctttcttgttcattgtctgtatttTCTTAACaaaaccagcag ctaAGGATTACAATGACTATAAActggaattggccttttataaacagccagttttcat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(532356..532375) /Source="Nicolas_upshift_promotors" /id="U405" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.811188811188811" /psig="0.997002997002997" /xcortree=412 /SigmaFactorBS="cgttgttctcctaactggtatgcatttttttatgaaaactgg cTGTTTATAaaaggccaattccaGTTTATAGTCATTGTAATCCttagctgctggtttt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 532370 /Source="Nicolas_upshifts" /id="U404" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.548451548451548" /psig="0.97002997002997" /xcortree=639 /SigmaFactorBS="ctttcttgttcattgtctgtatttTCTTAACaaaaccagcag ctaAGGATTACAATGACTATAAActggaattggccttttataaacagccagttttcat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(532380) /Source="Nicolas_upshifts" /id="U405" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.811188811188811" /psig="0.997002997002997" /xcortree=412 /SigmaFactorBS="cgttgttctcctaactggtatgcatttttttatgaaaactgg cTGTTTATAaaaggccaattccaGTTTATAGTCATTGTAATCCttagctgctggtttt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(532390..532397) /Source="Nicolas_upshift_promotors" /id="U405" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.811188811188811" /psig="0.997002997002997" /xcortree=412 /SigmaFactorBS="cgttgttctcctaactggtatgcatttttttatgaaaactgg cTGTTTATAaaaggccaattccaGTTTATAGTCATTGTAATCCttagctgctggtttt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 532446..533837 /gene="ydeL" /locus_tag="BSU_05240" /old_locus_tag="BSU05240" /function="16.3: Control" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15223311, 28348215; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative PLP-dependent transcriptional regulator" /protein_id="NP_388405.1" /db_xref="EnsemblGenomes-Gn:BSU05240" /db_xref="EnsemblGenomes-Tr:CAB12331" /db_xref="GOA:P96669" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12139" /db_xref="UniProtKB/Swiss-Prot:P96669" /translation="MDITPFLNRTLDIPLYQQLYRYFKENMHRGRIQKGMKLPSKRLL ANQLSISQTTVERAYEQLAAEGYIVSKPRSGWFADYHDSDFAYDRMPSTTPIQQEAEE NKQWIDFHYGNVDSSYFPFSAWRKSMVNSLDQYGHELYRPGHVLGEFELRTLIAEYLY QSRGVHCGPEQVIIGAGNPILLQILCQVFEPNISIGYEDPGYPRARKIFEANRMNIVP IPVDDEGICIQKIKEQQPNLVYVTPSHQFTLGTIMTINRRIQLLKWAAENQSFIIEDD YDGEFRYTGQPVPSLQGLDQHNRVIYMGTFSKSLLPSLRISYMILPSPLLKKGHEITS LYKQTVSCHSQLTLAEFIKNGEWQKHINRMRKLYRKKRAIVLEAVQRELGEHVRIRGE NSGLRILLDVYLPFGEKELIEKAKKHGVKIYPVSLSYQHHPPTKTVSLGFAGVSESDI REGIKKLKAAWKI*" /label="ydeL CDS" gene 532446..533837 /gene="ydeL" /locus_tag="BSU_05240" /old_locus_tag="BSU05240" /label="ydeL gene" promotor_-35 533965..533972 /Source="Nicolas_upshift_promotors" /id="U406" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2260 /SigmaFactorBS="gatacgtctgtttagcgaaaaacagaatTTTTTATTtgctcc tcacAGTGCTAAAATAAACAAAATagacaattgaaaaaatagaggtgtaagaatgaag t" /listShort="ydeM, S183" /listLong="ydeO" /label="promotor_-35" promotor_-10 533983..534002 /Source="Nicolas_upshift_promotors" /id="U406" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2260 /SigmaFactorBS="gatacgtctgtttagcgaaaaacagaatTTTTTATTtgctcc tcacAGTGCTAAAATAAACAAAATagacaattgaaaaaatagaggtgtaagaatgaag t" /listShort="ydeM, S183" /listLong="ydeO" /label="promotor_-10" upshifts 533997 /Source="Nicolas_upshifts" /id="U406" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2260 /SigmaFactorBS="gatacgtctgtttagcgaaaaacagaatTTTTTATTtgctcc tcacAGTGCTAAAATAAACAAAATagacaattgaaaaaatagaggtgtaagaatgaag t" /listShort="ydeM, S183" /listLong="ydeO" /label="upshifts" CDS 534031..534456 /gene="ydeM" /locus_tag="BSU_05250" /old_locus_tag="BSU05250" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 1556068, 26349822; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dehydratase" /protein_id="NP_388406.1" /db_xref="EnsemblGenomes-Gn:BSU05250" /db_xref="EnsemblGenomes-Tr:CAB12332" /db_xref="InterPro:IPR002539" /db_xref="InterPro:IPR029069" /db_xref="SubtiList:BG12140" /db_xref="UniProtKB/Swiss-Prot:P96670" /translation="MKLDEFTIGQVFKTKSLKVSKDDIMRFAGEFDPQYMHVDEEKAS KGRFNGIIASGIQTLAISFKLWIEEGFYGDDIIAGTEMNHMTFIKPVYPDDELFTIVE VLDKQPKRNELGILTVLLSTYNQKEVKVFEGELSVLIKR*" /label="ydeM CDS" gene 534031..534456 /gene="ydeM" /locus_tag="BSU_05250" /old_locus_tag="BSU05250" /label="ydeM gene" S_feature 534457..535711 /Source="Nicolas_S_feature" /locus_tag="new_573400_574654" /HighExp="G135, H2O2, G150, HiOs, G180, Cold, Paraq, UNK1, MG 15, LBGexp" /AntisenseName="ydeN" /AntisenseCor="0.40423774227585801" /AntisenseRegPval="-11.3" /CDS_PredictionProba="0.127641" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S183" CDS complement(534509..535081) /gene="ydeN" /locus_tag="BSU_05260" /old_locus_tag="BSU05260" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15159570; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative alpha/beta hydrolase" /protein_id="NP_388407.1" /db_xref="EnsemblGenomes-Gn:BSU05260" /db_xref="EnsemblGenomes-Tr:CAB12333" /db_xref="GOA:P96671" /db_xref="InterPro:IPR010662" /db_xref="InterPro:IPR029058" /db_xref="PDB:1UXO" /db_xref="SubtiList:BG12141" /db_xref="UniProtKB/Swiss-Prot:P96671" /translation="MTKQVYIIHGYRASSTNHWFPWLKKRLLADGVQADILNMPNPLQ PRLEDWLDTLSLYQHTLHENTYLVAHSLGCPAILRFLEHLQLRKQLGGIILVSGFAKS LPTLQMLDEFTQGSFDHQKIIESAKHRAVIASKDDQIVPFSFSKDLAQQIDAALYEVQ HGGHFLEDEGFTSLPIVYDVLTSYFSKETR*" /label="ydeN CDS" gene complement(534509..535081) /gene="ydeN" /locus_tag="BSU_05260" /old_locus_tag="BSU05260" /label="ydeN gene" downshifts complement(534514) /Source="Nicolas_upshifts" /id="D250" /incds=0 /nref=16 /ntot=160 /MaxReadThrough="1.96868" /MaxDrop="3.80195" /score="2.50673989" /energy="-11.3" /TU="NA" /idTUdmin="U407" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(535082..535162) /Source="Nicolas_S_feature" /locus_tag="new_574025_574105_c" /HighExp="dia15, dia5, Diami, Etha, LPhT, Lbtran, Heat, H2O2, Sw, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.955" /TUlongSig="NA" /TUlongPSig="NA" /label="S184" CDS complement(535163..535492) /gene="ydzF" /locus_tag="BSU_05270" /old_locus_tag="BSU05270" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_388408.1" /db_xref="EnsemblGenomes-Gn:BSU05270" /db_xref="EnsemblGenomes-Tr:CAB12334" /db_xref="GOA:O31494" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12809" /db_xref="UniProtKB/Swiss-Prot:O31494" /translation="MNSLCRSKQAPFEYTLSLIGGKWKMRILYELGCEKTMRYGELKR AMPFITHKMLSAQLKELQTDGLIHRSEVSHTPLKVEYSLSDRGRSLYPLIDEMCKWGM AQGGPHM*" /label="ydzF CDS" gene complement(535163..535492) /gene="ydzF" /locus_tag="BSU_05270" /old_locus_tag="BSU05270" /label="ydzF gene" misc_feature complement(535509..535528) /Source="Nicolas_upshift_promotors" /id="U407" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.416583416583417" /psig="0.955044955044955" /xcortree=1959 /SigmaFactorBS="cctttcacttcagatcgtgaatcgccctcaaacttcaacacc gaaaatcctaatttatTCTGATATGATACTTAAAAAaggaggtttgattacaatgaat a" /listShort="ydzF, S184, ydeN" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(535526) /Source="Nicolas_upshifts" /id="U407" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.416583416583417" /psig="0.955044955044955" /xcortree=1959 /SigmaFactorBS="cctttcacttcagatcgtgaatcgccctcaaacttcaacacc gaaaatcctaatttatTCTGATATGATACTTAAAAAaggaggtttgattacaatgaat a" /listShort="ydzF, S184, ydeN" /GFF_Attribute="listLong" /label="upshifts" misc_feature 535700..535719 /Source="Nicolas_upshift_promotors" /id="U408" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.78021978021978" /psig=1 /xcortree=2345 /SigmaFactorBS="agttactttatttaaaaaaacgcatgtttttagctgaaaata tctatTATGGTATATTTAAATATAAagaaatatttgagaaatgaggaatggtatgaat a" /listShort="ydeO" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 535713 /Source="Nicolas_upshifts" /id="U408" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.78021978021978" /psig=1 /xcortree=2345 /SigmaFactorBS="agttactttatttaaaaaaacgcatgtttttagctgaaaata tctatTATGGTATATTTAAATATAAagaaatatttgagaaatgaggaatggtatgaat a" /listShort="ydeO" /GFF_Attribute="listLong" /label="upshifts" CDS 535747..536619 /gene="ydeO" /locus_tag="BSU_05280" /old_locus_tag="BSU05280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388409.1" /db_xref="EnsemblGenomes-Gn:BSU05280" /db_xref="EnsemblGenomes-Tr:CAB12335" /db_xref="GOA:P96672" /db_xref="InterPro:IPR003740" /db_xref="InterPro:IPR019264" /db_xref="SubtiList:BG12142" /db_xref="UniProtKB/Swiss-Prot:P96672" /translation="MNTPKKHKKFKAKMILQIIMVIIGGIIAAYGLETVLIPNSVSDG GVTGLSIVGSQLFNLPLGILIAVINIPFVWLGYKQIGKSFALLSIIGIVSLAAGTSFF HHTPAIIEGDTLLITVVGGIILGFGMGLALRNGGALDGIDMLAVLLSRKLPFGTSDLI LFLNLFVFIFVSTVFGLQGALLSVIAYYIASKVIHVVEEGLSGSKTFQIITTQPELMV ETIRDQLGRSATYKEAYGGFSHEKFKEITCVINRLEETKLKEIINDIDKTAFVTVYDV AEVKGSNFRNLNHH*" /label="ydeO CDS" gene 535747..536619 /gene="ydeO" /locus_tag="BSU_05280" /old_locus_tag="BSU05280" /label="ydeO gene" downshifts 536506 /Source="Nicolas_upshifts" /id="D251" /incds=1 /nref=7 /ntot=181 /MaxReadThrough="3.84278" /MaxDrop="2.68681" /score="15.0132064" /energy="-12.2" /TU="U408" /idTUdmin="U408" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" downshifts 536704 /Source="Nicolas_upshifts" /id="D252" /incds=0 /nref=54 /ntot=208 /MaxReadThrough="1.19842" /MaxDrop="3.77294" /score="15.0132064" /energy="-12.2" /TU="NA" /idTUdmin="U408" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(536769..537155) /gene="ydeP" /locus_tag="BSU_05290" /old_locus_tag="BSU05290" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_388410.1" /db_xref="EnsemblGenomes-Gn:BSU05290" /db_xref="EnsemblGenomes-Tr:CAB12336" /db_xref="GOA:P96673" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12143" /db_xref="UniProtKB/Swiss-Prot:P96673" /translation="MRNRKLGIDYSSDDFEGCPVETTLDIIGGKWKGILLYHLIDGKK RFNEFRKLYPKITQRMLTLQLRELERDGVIHREVYKQVPPKVEYSLTEFGRTLEPVIL HMKDWGEKYKDRIDKLEAARKAEDKI*" /label="ydeP CDS" gene complement(536769..537155) /gene="ydeP" /locus_tag="BSU_05290" /old_locus_tag="BSU05290" /label="ydeP gene" downshifts complement(536781) /Source="Nicolas_upshifts" /id="D253" /incds=0 /nref=29 /ntot=191 /MaxReadThrough="0.85093" /MaxDrop="4.4837" /score="-9.3516261" /energy="-12.9" /TU="NA" /idTUdmin="U409" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" S_feature complement(537156..537220) /Source="Nicolas_S_feature" /locus_tag="new_576099_576163_c" /HighExp="Diami, dia5, Salt, dia15, Etha, Heat, G180, HiOs, LBGexp, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S185" promotor_-35 537208..537215 /Source="Nicolas_upshift_promotors" /id="U410" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.67032967032967" /psig="0.936063936063936" /xcortree=1790 /SigmaFactorBS="agtatactttttgatactatatacattcaatgtgcgTACTTT TTatattttaatataCATCATATAATGATGTCACAtctaaggaatgaaaggaatggat c" /listShort="ydeQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(537209..537228) /Source="Nicolas_upshift_promotors" /id="U409" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.568431568431568" /psig="0.999000999001" /xcortree=1896 /SigmaFactorBS="gttttcatatgatccattcctttcattccttaGATGTGACat cattatatgatgTATATTAAAATATAAAAAGTacgcacattgaatgtatatagtatca a" /listShort="S185, ydeP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(537222) /Source="Nicolas_upshifts" /id="U409" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.568431568431568" /psig="0.999000999001" /xcortree=1896 /SigmaFactorBS="gttttcatatgatccattcctttcattccttaGATGTGACat cattatatgatgTATATTAAAATATAAAAAGTacgcacattgaatgtatatagtatca a" /listShort="S185, ydeP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 537229..537248 /Source="Nicolas_upshift_promotors" /id="U410" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.67032967032967" /psig="0.936063936063936" /xcortree=1790 /SigmaFactorBS="agtatactttttgatactatatacattcaatgtgcgTACTTT TTatattttaatataCATCATATAATGATGTCACAtctaaggaatgaaaggaatggat c" /listShort="ydeQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 537232 /Source="Nicolas_upshifts" /id="U410" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.67032967032967" /psig="0.936063936063936" /xcortree=1790 /SigmaFactorBS="agtatactttttgatactatatacattcaatgtgcgTACTTT TTatattttaatataCATCATATAATGATGTCACAtctaaggaatgaaaggaatggat c" /listShort="ydeQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(537243..537250) /Source="Nicolas_upshift_promotors" /id="U409" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.568431568431568" /psig="0.999000999001" /xcortree=1896 /SigmaFactorBS="gttttcatatgatccattcctttcattccttaGATGTGACat cattatatgatgTATATTAAAATATAAAAAGTacgcacattgaatgtatatagtatca a" /listShort="S185, ydeP" /GFF_Attribute="listLong" /label="promotor_-35" CDS 537266..537859 /gene="ydeQ" /locus_tag="BSU_05300" /old_locus_tag="BSU05300" /EC_number="1.6.99.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD(P)H oxidoreductase involved in regulating potassium efflux" /protein_id="NP_388411.1" /db_xref="EnsemblGenomes-Gn:BSU05300" /db_xref="EnsemblGenomes-Tr:CAB12337" /db_xref="GOA:P96674" /db_xref="InterPro:IPR003680" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG12144" /db_xref="UniProtKB/Swiss-Prot:P96674" /translation="MDHMKTLVLVVHPNIESSRINKKWKEAVLSEPDVTVHDLYEKYR DQPIDVEFEQQQLLAHDRIVFQFPLYWYSSPPLLKQWFDEVFTFGWAHGPGGNKLKGK EWVTAMSIGSPEHSYQAGGYNLFSISELTKPFQASAHLVGMTYLPSFAEYRANTISDQ EIAESANRYVKHITNIELNPKVRLQRYLKQLESVDLT*" /label="ydeQ CDS" gene 537266..537859 /gene="ydeQ" /locus_tag="BSU_05300" /old_locus_tag="BSU05300" /label="ydeQ gene" CDS complement(538003..539190) /gene="ydeR" /locus_tag="BSU_05310" /old_locus_tag="BSU05310" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388412.1" /db_xref="EnsemblGenomes-Gn:BSU05310" /db_xref="EnsemblGenomes-Tr:CAB12338" /db_xref="GOA:P96675" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12145" /db_xref="UniProtKB/Swiss-Prot:P96675" /translation="MANGNKQAGQRISPSLTLLLATACGIIVANLYYAQPLVGLISKA IGLSPSGAGLIVTLTQIGYVAGLLFLVPLGDIIENKKLIVVSLLLSAAALTLTAFVKH GTLFLAAAFFVGLGSIAAQVLVPFASYLASDAARGRVVGNVMSGLLLGIMLSRPISSL VADIWGWNAIFALSAVVSVILAIVLSKVLPARKPTANTNYTALLGSMWKLLRTTPVLR RRAIYHAFVFGAFSLFWTTVPLLLSGPDFHFSQKAIALYALVGIAGAVTAPIGGRLAD RGLTRLATGIALGVVVVSLLLPLMIQSSSPVGITVLVAAAILLDMGVSANLVLSQRAI FSLAPEIRSRLNGLFMAIFFLGGAIGSSIGGWAYASGGWSTALWIGIAFPVIALLYFI TEK*" /label="ydeR CDS" gene complement(538003..539190) /gene="ydeR" /locus_tag="BSU_05310" /old_locus_tag="BSU05310" /label="ydeR gene" promotor_-35 539326..539330 /Source="Nicolas_upshift_promotors" /id="U411" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.605394605394605" /psig="0.999000999001" /xcortree=2381 /SigmaFactorBS="aaaaataatatactaaacgttcagttttgtaaatggatttct GTTTTctttttttattcaaTTTAAGTATACTGAACGTATagtttatattgcgggaagg a" /listShort="ydeS, ydzO" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 539344 /Source="Nicolas_upshifts" /id="U411" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.605394605394605" /psig="0.999000999001" /xcortree=2381 /SigmaFactorBS="aaaaataatatactaaacgttcagttttgtaaatggatttct GTTTTctttttttattcaaTTTAAGTATACTGAACGTATagtttatattgcgggaagg a" /listShort="ydeS, ydzO" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 539345..539364 /Source="Nicolas_upshift_promotors" /id="U411" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.605394605394605" /psig="0.999000999001" /xcortree=2381 /SigmaFactorBS="aaaaataatatactaaacgttcagttttgtaaatggatttct GTTTTctttttttattcaaTTTAAGTATACTGAACGTATagtttatattgcgggaagg a" /listShort="ydeS, ydzO" /GFF_Attribute="listLong" /label="promotor_-10" CDS 539394..539990 /gene="ydeS" /locus_tag="BSU_05320" /old_locus_tag="BSU05320" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15944459; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (TetR/AcrR family)" /protein_id="NP_388413.1" /db_xref="EnsemblGenomes-Gn:BSU05320" /db_xref="EnsemblGenomes-Tr:CAB12339" /db_xref="GOA:P96676" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR011075" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG12146" /db_xref="UniProtKB/Swiss-Prot:P96676" /translation="MQSKRGRPRDEGTHKAILSAAYDLLLEKGFDAVTVDKIAERAKV SKATIYKWWSNKAAVIMDSFLSTATDRLPVPDTGSSVQDIVTHATNLARFLTSREGTV IKELIGAGQLDEKLAEEYRTRFFQPRRLQAKGLLEKGIQKGELRENLDIEVSIDLIYG PIFYRLLITGDEVNDSYVRDLVMNAFKGVQATSATESM*" /label="ydeS CDS" gene 539394..539990 /gene="ydeS" /locus_tag="BSU_05320" /old_locus_tag="BSU05320" /label="ydeS gene" CDS 540104..540289 /gene="ydzO" /locus_tag="BSU_05329" /old_locus_tag="BSU05329" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097684.1" /db_xref="EnsemblGenomes-Gn:BSU05329" /db_xref="EnsemblGenomes-Tr:CAX52555" /db_xref="UniProtKB/Swiss-Prot:C0H3V9" /translation="MSKKKSFNREYITSYYYIPFHRLEQGFYTSMEYRKVGVFKQQGK IDGHYVGVMAMEKILAM*" /label="ydzO CDS" gene 540104..540289 /gene="ydzO" /locus_tag="BSU_05329" /old_locus_tag="BSU05329" /label="ydzO gene" downshifts 540268 /Source="Nicolas_upshifts" /id="D254" /incds=0 /nref=5 /ntot=123 /MaxReadThrough="1.06987" /MaxDrop="2.89833" /score="-5.04743481" /energy="-6.3" /TU="NA" /idTUdmin="U411" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 540401..540404 /Source="Nicolas_upshift_promotors" /id="U412" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.356643356643357" /psig="0.99000999000999" /xcortree=2480 /SigmaFactorBS="tctatgaccactcccataactgaaatagtctaatatttatac cagaagggATTGtttatataaataaaAGTTTATATAATGACGGGGGcgctaaggaaac g" /listShort="S186, aseR, ydfA, ydzS, ydzS" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 540411..540597 /Source="Nicolas_S_feature" /locus_tag="new_579354_579540" /HighExp="LBGstat, G180, LBGexp, G135, Paraq, G150, Oxctl, dia0, Diami, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S186" upshifts 540411 /Source="Nicolas_upshifts" /id="U412" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.356643356643357" /psig="0.99000999000999" /xcortree=2480 /SigmaFactorBS="tctatgaccactcccataactgaaatagtctaatatttatac cagaagggATTGtttatataaataaaAGTTTATATAATGACGGGGGcgctaaggaaac g" /listShort="S186, aseR, ydfA, ydzS, ydzS" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 540419..540438 /Source="Nicolas_upshift_promotors" /id="U412" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.356643356643357" /psig="0.99000999000999" /xcortree=2480 /SigmaFactorBS="tctatgaccactcccataactgaaatagtctaatatttatac cagaagggATTGtttatataaataaaAGTTTATATAATGACGGGGGcgctaaggaaac g" /listShort="S186, aseR, ydfA, ydzS, ydzS" /GFF_Attribute="listLong" /label="promotor_-10" CDS 540598..540933 /gene="aseR" /locus_tag="BSU_05330" /old_locus_tag="BSU05330" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:15948947, 16430705" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15948947, 16430705; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (metals sensing ArsR-SmtB repressors family)" /protein_id="NP_388414.1" /db_xref="EnsemblGenomes-Gn:BSU05330" /db_xref="EnsemblGenomes-Tr:CAB12340" /db_xref="GOA:P96677" /db_xref="InterPro:IPR001845" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12147" /db_xref="UniProtKB/Swiss-Prot:P96677" /translation="MTIDVAAMTRCLKTLSDQTRLIMMRLFLEQEYCVCQLVDMFEMS QPAISQHLRKLKNAGFVNEDRRGQWRYYSINGSCPEFDTLQLILHQIDQEDELLNHIK QKKTQACCQ*" /label="aseR CDS" gene 540598..540933 /gene="aseR" /locus_tag="BSU_05330" /old_locus_tag="BSU05330" /label="aseR gene" CDS 540946..542253 /gene="arsF" /locus_tag="BSU_05340" /old_locus_tag="BSU05340" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12950922, 14970228, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="arsenite/antimonite/H+ antiporter" /protein_id="NP_388415.1" /db_xref="EnsemblGenomes-Gn:BSU05340" /db_xref="EnsemblGenomes-Tr:CAB12341" /db_xref="GOA:P96678" /db_xref="InterPro:IPR000802" /db_xref="SubtiList:BG12148" /db_xref="UniProtKB/Swiss-Prot:P96678" /translation="MTSMILAVFIFLLTLVLVIWQPKNLSIGWSACGGAVLALIAGVV NFHDVLTVTGIVWNATLAFVAIILISLILDNIGFFEWAALHMAKAAKGYGVRMFVYVS LLGAIVAALFANDGAALILTPIVLAMVRALHFNEKLVFPFIIASGFIADTTSLPFVVS NLVNIVSADYFHITFIDYASRMVVPYLFSLLASIIVLYLFFRKSIPKRYDLTEVKKPV EAIKDQNMFRLSWYILGLLLIGYFASEFFSIPVSVVAGSIAIIFLIAAQKSPAVHTKK VVKEAPWAIVFFSIGMYVVVYGVRNAGLTDVLSDVIQAAADQGLFAGTIGMGFIAAIL SSIMNNLPTVMIDALAIAGTDTHGMMREALIYANVIGSDLGPKITPIGSLATLLWLHV LSHKGMKISWGTYFKTGIILTIPTLLITLVGLYIWLLIIHSCF*" /label="arsF CDS" gene 540946..542253 /gene="arsF" /locus_tag="BSU_05340" /old_locus_tag="BSU05340" /label="arsF gene" CDS 542285..542389 /gene="ydzSn" /locus_tag="BSU_05343" /old_locus_tag="BSU05343" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; N-terminal part of ydzS" /translation="CTGNSCRSQMAEGWGRKYLGAKWNVYSAGIEAQG*" /label="ydzSn CDS" gene 542285..542389 /gene="ydzSn" /locus_tag="BSU_05343" /old_locus_tag="BSU05343" /pseudo /label="ydzSn gene" CDS 542398..542511 /gene="ydzSc" /locus_tag="BSU_05344" /old_locus_tag="BSU05344" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; C-terminal part of ydzS" /translation="AVKAMKEAGIDISNQTSEKFDDPAKAHGTEEVFPKGP*" /label="ydzSc CDS" gene 542398..542511 /gene="ydzSc" /locus_tag="BSU_05344" /old_locus_tag="BSU05344" /pseudo /label="ydzSc gene" promotor_-35 542697..542705 /Source="Nicolas_upshift_promotors" /id="U413" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=429 /SigmaFactorBS="cagggaagttatttagctggtgacAGAGGAAAAttgatttgt gAACAGAATCATGAAGGAGAcggtgttttaaaggagttgtctgttttgcaggaattaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 542716..542734 /Source="Nicolas_upshift_promotors" /id="U413" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=429 /SigmaFactorBS="cagggaagttatttagctggtgacAGAGGAAAAttgatttgt gAACAGAATCATGAAGGAGAcggtgttttaaaggagttgtctgttttgcaggaattaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 542733 /Source="Nicolas_upshifts" /id="U413" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=429 /SigmaFactorBS="cagggaagttatttagctggtgacAGAGGAAAAttgatttgt gAACAGAATCATGAAGGAGAcggtgttttaaaggagttgtctgttttgcaggaattaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 542751..543536 /gene="ydfB" /locus_tag="BSU_05350" /old_locus_tag="BSU05350" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12793527; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_388416.1" /db_xref="EnsemblGenomes-Gn:BSU05350" /db_xref="EnsemblGenomes-Tr:CAB12342" /db_xref="GOA:P96679" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR027365" /db_xref="SubtiList:BG12149" /db_xref="UniProtKB/Swiss-Prot:P96679" /translation="MSVLQELTKKKYSSLKTMFDDKYCPTFVYSILDQTIPGAVYADD QTFPKSFFIGTESGIYFIAGDQGNRDFHDFIAGYYEEQVKSSKRFTLFSSSDTWDSVL KPILKDDLNQMRRAAFSYQPKSFKKTLQLPKGLVLKRIDEDIISHSTAFNSAYYEEYW NSVSQFASKGFGFAVLHGNHVVSECTSIFLGHNRAEMDIYTLEEYRGLGLAYCVANRF IAFCMENGIVPSWDCDICNNSSIALAAKLGFKTVTEYTIYYSG*" /label="ydfB CDS" gene 542751..543536 /gene="ydfB" /locus_tag="BSU_05350" /old_locus_tag="BSU05350" /label="ydfB gene" downshifts 542798 /Source="Nicolas_upshifts" /id="D255" /incds=0 /nref=3 /ntot=24 /MaxReadThrough="2.67554" /MaxDrop="5.08398" /score="39.1565399" /energy="-19.2" /TU="NA" /idTUdmin="U413" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 543546 /Source="Nicolas_upshifts" /id="D256" /incds=0 /nref=2 /ntot=90 /MaxReadThrough="0.161840000000001" /MaxDrop="3.51451" /score="-0.169292431" /energy="-13.6" /TU="NA" /idTUdmin="U413" /TUdmin=748 /isTUend="FALSE" /label="downshifts" CDS complement(543593..544513) /gene="ydfC" /locus_tag="BSU_05360" /old_locus_tag="BSU05360" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative aminoacid exporter" /protein_id="NP_388417.1" /db_xref="EnsemblGenomes-Gn:BSU05360" /db_xref="EnsemblGenomes-Tr:CAB12343" /db_xref="GOA:P96680" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG12150" /db_xref="UniProtKB/Swiss-Prot:P96680" /translation="MRKKTVQIMISHSLMIGLWASAFPGIRAGLEGYTPEHLALFRLL IGSMALLLFAVLTQMRLPDLKDIPAIFLLGFLGFAFYHILLNIGEKTVSAGVASLLVT TAPIFSAMLSRLFYKEHFGFTKWLGSMISLLGVLLIAFGAGDFTYSMSGILVILLAAF SESIYFVFQARYIKKYGFIPFVTFTIWGGTIPMLVFLPGLGEEMMNASISATLSIVYL GLLPTVIPYFALAYVTSFVGASEATLSLYVTPALALIISWLWIGEIPTLLSLLGGVVT VGGVCFTYLKVNKMNKIFITHFSAKRVKKL*" /label="ydfC CDS" gene complement(543593..544513) /gene="ydfC" /locus_tag="BSU_05360" /old_locus_tag="BSU05360" /label="ydfC gene" CDS 544646..546094 /gene="ydfD" /locus_tag="BSU_05370" /old_locus_tag="BSU05370" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15223311, 28348215; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative PLP-dependent transcriptional regulator" /protein_id="NP_388418.1" /db_xref="EnsemblGenomes-Gn:BSU05370" /db_xref="EnsemblGenomes-Tr:CAB12344" /db_xref="GOA:P96681" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12151" /db_xref="UniProtKB/Swiss-Prot:P96681" /translation="MSFPEEKKMKKLPKYRQIVHFIKEKIGNGEWPIGSKIPSQRTLA KDFQVNRSTVITALEELMADGLIEGTMGKGTVVINNTWTLMAKNSAPDWDQYVTSGIQ MPSRKIVQEINQSESNTDLIQLSKGELSAEIFPLAVMKEMMGKVSQHMEAFGYEEPKG YLPLREALSNYLKTIGINVSSSSILIVSGALQALQLISMGLLQRGSTVYLDQPSYLYS LHVFQSAGMKLTGLPMDNEGLLPENVHLTRGERGRAILYTNPCFHNPTGILMSKKRRE EILAVSENTQLPIIEDDIYRELWIDEIPPYPIKTIDKNGHVLYIGSLSKTLSPGLRIG WIVGPEPVIERLSDIKMQTDYGSSSLSQRVAAEWFTSGHYQQHVEKVRQQLKVRRELA LSALETHLKEVATWNIPKGGFFVWIKILPSISMKLLYTKALSKGILINLGSIYAQEKG NYIRLSYAYASLEDLQKGIYELGLMIKELASR*" /label="ydfD CDS" gene 544646..546094 /gene="ydfD" /locus_tag="BSU_05370" /old_locus_tag="BSU05370" /label="ydfD gene" CDS complement(546212..546835) /gene="ydfE" /locus_tag="BSU_05380" /old_locus_tag="BSU05380" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative flavoprotein" /protein_id="NP_388419.1" /db_xref="EnsemblGenomes-Gn:BSU05380" /db_xref="EnsemblGenomes-Tr:CAB12345" /db_xref="GOA:P96682" /db_xref="InterPro:IPR002563" /db_xref="InterPro:IPR012349" /db_xref="SubtiList:BG12152" /db_xref="UniProtKB/Swiss-Prot:P96682" /translation="MDIKKQDTRRFKEIKPKIMYYGTSTFLLTTLNEDGTTNISPMSS SWALGHYIILGVGLGGKAIDNLERHKECVINLPGPDLWENVERISSYSGKKSIPPLKK QIGFTYKKEKYEAAGLTPLQSKTVSPTRIKECPIQIEAEVKHIRLPEYESSFAIVETQ ALHFHAEESIILDENHINPSKWSPLIYNFRHYFGLGREVGKTFRSET*" /label="ydfE CDS" gene complement(546212..546835) /gene="ydfE" /locus_tag="BSU_05380" /old_locus_tag="BSU05380" /label="ydfE gene" promotor_-10 complement(546859..546878) /Source="Nicolas_upshift_promotors" /id="U414" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.398601398601399" /psig="0.999000999001" /xcortree=2726 /SigmaFactorBS="atattaggattcatgattttcctccttacattcatatttCGA TGATagttgaaatgttaaTCCTTTACAATATAAATGTAagcgtgacaaggaggaaaaa a" /listShort="ydfE" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 546867..546874 /Source="Nicolas_upshift_promotors" /id="U415" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.815184815184815" /psig=1 /xcortree=2389 /SigmaFactorBS="tccaacgttttttcctccttgtcacgcttacatttaTATTGT AAaggattaacatttcAACTATCATCGAAATATGAAtgtaaggaggaaaatcatgaat c" /listShort="ydfF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(546878) /Source="Nicolas_upshifts" /id="U414" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.398601398601399" /psig="0.999000999001" /xcortree=2726 /SigmaFactorBS="atattaggattcatgattttcctccttacattcatatttCGA TGATagttgaaatgttaaTCCTTTACAATATAAATGTAagcgtgacaaggaggaaaaa a" /listShort="ydfE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 546889..546908 /Source="Nicolas_upshift_promotors" /id="U415" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.815184815184815" /psig=1 /xcortree=2389 /SigmaFactorBS="tccaacgttttttcctccttgtcacgcttacatttaTATTGT AAaggattaacatttcAACTATCATCGAAATATGAAtgtaaggaggaaaatcatgaat c" /listShort="ydfF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 546891 /Source="Nicolas_upshifts" /id="U415" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.815184815184815" /psig=1 /xcortree=2389 /SigmaFactorBS="tccaacgttttttcctccttgtcacgcttacatttaTATTGT AAaggattaacatttcAACTATCATCGAAATATGAAtgtaaggaggaaaatcatgaat c" /listShort="ydfF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(546893..546899) /Source="Nicolas_upshift_promotors" /id="U414" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.398601398601399" /psig="0.999000999001" /xcortree=2726 /SigmaFactorBS="atattaggattcatgattttcctccttacattcatatttCGA TGATagttgaaatgttaaTCCTTTACAATATAAATGTAagcgtgacaaggaggaaaaa a" /listShort="ydfE" /GFF_Attribute="listLong" /label="promotor_-35" CDS 546925..547605 /gene="ydfF" /locus_tag="BSU_05390" /old_locus_tag="BSU05390" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_388420.1" /db_xref="EnsemblGenomes-Gn:BSU05390" /db_xref="EnsemblGenomes-Tr:CAB12346" /db_xref="GOA:P96683" /db_xref="InterPro:IPR001845" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12153" /db_xref="UniProtKB/Swiss-Prot:P96683" /translation="MNPNIAKISSLLSDPSRSSILLSLMDGRIHPAGELAYLANIKPQ TASFHLNKLLEAKLISVEKHGRHRYYRLADSDAANVIEQLLHIAPKAKVKSLKESKEK KDLHFARTCYDHLAGYVGVQMAHSLVEQGMLKKVDLNFEVTSEGALFFSKLGINEEQQ RNKRRAFARCCLDWSERQHHIAGALGNALLVRMLEEEWIVRMPKTRAIRITQSGKIAF EKHLNVKI*" /label="ydfF CDS" gene 546925..547605 /gene="ydfF" /locus_tag="BSU_05390" /old_locus_tag="BSU05390" /label="ydfF gene" downshifts 547638 /Source="Nicolas_upshifts" /id="D257" /incds=0 /nref=113 /ntot=245 /MaxReadThrough="0.50202" /MaxDrop="4.24716" /score="-7.74889591" /energy="-4.5" /TU="U415" /idTUdmin="U415" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(547685..548128) /gene="ydfG" /locus_tag="BSU_05400" /old_locus_tag="BSU05400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388421.1" /db_xref="EnsemblGenomes-Gn:BSU05400" /db_xref="EnsemblGenomes-Tr:CAB12347" /db_xref="GOA:P96684" /db_xref="InterPro:IPR003779" /db_xref="InterPro:IPR004675" /db_xref="InterPro:IPR029032" /db_xref="SubtiList:BG12154" /db_xref="UniProtKB/Swiss-Prot:P96684" /translation="MSQRVSYYEIAPEGMKIMMDMEKYTKQSSINRTTRELIKIRVSQ MNGCAFCIDMHTSDARKMGETEQRIYCLHAWNECDFYSPEEKAALELSEHITLIPSKR VPDELYHRVREHYDEEQYVDLVLIINQINSWNRISIAMGNRAASK*" /label="ydfG CDS" gene complement(547685..548128) /gene="ydfG" /locus_tag="BSU_05400" /old_locus_tag="BSU05400" /label="ydfG gene" downshifts complement(547690) /Source="Nicolas_upshifts" /id="D258" /incds=0 /nref=10 /ntot=187 /MaxReadThrough="1.76648" /MaxDrop="3.73786" /score="0.225628164" /energy="-10.8" /TU="NA" /idTUdmin="U416" /TUdmin=2 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(548151..548170) /Source="Nicolas_upshift_promotors" /id="U416" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2022 /SigmaFactorBS="gcttctttccaaaagacgctgaaacagctgtcattcaaaccg caCATTGGTAaaatgatcaatacCGGGATACAATCTAGGTATTctatggaaaggagtc t" /listShort="ydfG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(548175) /Source="Nicolas_upshifts" /id="U416" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2022 /SigmaFactorBS="gcttctttccaaaagacgctgaaacagctgtcattcaaaccg caCATTGGTAaaatgatcaatacCGGGATACAATCTAGGTATTctatggaaaggagtc t" /listShort="ydfG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(548184..548191) /Source="Nicolas_upshift_promotors" /id="U416" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2022 /SigmaFactorBS="gcttctttccaaaagacgctgaaacagctgtcattcaaaccg caCATTGGTAaaatgatcaatacCGGGATACAATCTAGGTATTctatggaaaggagtc t" /listShort="ydfG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(548214..548393) /gene="ydzP" /locus_tag="BSU_05408" /old_locus_tag="BSU05408" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097685.1" /db_xref="EnsemblGenomes-Gn:BSU05408" /db_xref="EnsemblGenomes-Tr:CAX52558" /db_xref="GOA:C0H3W0" /db_xref="UniProtKB/Swiss-Prot:C0H3W0" /translation="MNMYWFLGALLYFLIGTYIFIRVTRDSQSGSWILLALAAPLIIA GYPYFYSKKLLSKRR*" /label="ydzP CDS" gene complement(548214..548393) /gene="ydzP" /locus_tag="BSU_05408" /old_locus_tag="BSU05408" /label="ydzP gene" CDS complement(548390..548533) /gene="ydzQ" /locus_tag="BSU_05409" /old_locus_tag="BSU05409" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097686.1" /db_xref="EnsemblGenomes-Gn:BSU05409" /db_xref="EnsemblGenomes-Tr:CAX52559" /db_xref="UniProtKB/Swiss-Prot:C0H3W1" /translation="MKSIDLTILSLKRKGIRTEKVLKNQNPDRLSHMTDKNAQPKSKE KEE*" /label="ydzQ CDS" gene complement(548390..548533) /gene="ydzQ" /locus_tag="BSU_05409" /old_locus_tag="BSU05409" /label="ydzQ gene" promotor_-35 548484..548486 /Source="Nicolas_upshift_promotors" /id="U417" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.649350649350649" /psig="0.998001998001998" /xcortree=2487 /SigmaFactorBS="tctgattttttaataccttttcggtcCGGattccttttctct ttAATGATAAAATTGTGAGATCaatcgatttcaatgatgatcattccttcaatgaata g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 548502..548521 /Source="Nicolas_upshift_promotors" /id="U417" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.649350649350649" /psig="0.998001998001998" /xcortree=2487 /SigmaFactorBS="tctgattttttaataccttttcggtcCGGattccttttctct ttAATGATAAAATTGTGAGATCaatcgatttcaatgatgatcattccttcaatgaata g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 548518 /Source="Nicolas_upshifts" /id="U417" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.649350649350649" /psig="0.998001998001998" /xcortree=2487 /SigmaFactorBS="tctgattttttaataccttttcggtcCGGattccttttctct ttAATGATAAAATTGTGAGATCaatcgatttcaatgatgatcattccttcaatgaata g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 548801..550024 /gene="ydfH" /locus_tag="BSU_05410" /old_locus_tag="BSU05410" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 15941986" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15941986; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YdfI]" /protein_id="NP_388422.1" /db_xref="EnsemblGenomes-Gn:BSU05410" /db_xref="EnsemblGenomes-Tr:CAB12348" /db_xref="GOA:P96685" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12155" /db_xref="UniProtKB/Swiss-Prot:P96685" /translation="MLIRNPFKDKYYSHDRRALNMLALRVPGLAFILMIYIASIVLQF VSGGWSILLLYAFTILIAIFALLHWHSYRWVKKRVILYFAVQGLITFALANLMTGFFI LVIIGLYAFLIGQIIGMADRRRTFLILYLLLLLVINSAYHLHKGEVLHFIVIAAPIMI VIITYAATFFAQVDEKIKAQLTLERLELAHQQVEQLTLQNERQRMARDLHDTLAQGLV SLNMQLDAIHVHLAKGNTERAKEIIQQSMKRVKSTIADARSAIDDLRSKSEEIGVLKE RITSLMDHFIESTGMACLLDYRLHQVLDVRTAENCYYIIGECMTNAAKHAEAKTIWIS IWDDEKGRLHLTVKDNGKGFDVEKGKKKRGHYGLLGIQERVRAINGQFNIKSTKLKGT QIEITVPIQGEMQDE*" /label="ydfH CDS" gene 548801..550024 /gene="ydfH" /locus_tag="BSU_05410" /old_locus_tag="BSU05410" /label="ydfH gene" CDS 550017..550658 /gene="ydfI" /locus_tag="BSU_05420" /old_locus_tag="BSU05420" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 15941986" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15941986; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YdfH]" /protein_id="NP_388423.1" /db_xref="EnsemblGenomes-Gn:BSU05420" /db_xref="EnsemblGenomes-Tr:CAB12349" /db_xref="GOA:P96686" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12156" /db_xref="UniProtKB/Swiss-Prot:P96686" /translation="MNKVLIVDDHLVVREGLKLLIETNDQYTIIGEAENGKVAVRLAD ELEPDIILMDLYMPEMSGLEAIKQIKEKHDTPIIILTTYNEDHLMIEGIELGAKGYLL KDTSSETLFHTMDAAIRGNVLLQPDILKRLQEIQFERMKKQRNETQLTEKEVIVLKAI AKGLKSKAIAFDLGVSERTVKSRLTSIYNKLGANSRTEAVTIAMQKGILTIDN*" /label="ydfI CDS" gene 550017..550658 /gene="ydfI" /locus_tag="BSU_05420" /old_locus_tag="BSU05420" /label="ydfI gene" downshifts 550652 /Source="Nicolas_upshifts" /id="D259" /incds=0 /nref=5 /ntot=147 /MaxReadThrough="1.15378" /MaxDrop="2.65603" /score="8.33575703" /energy="-6.4" /TU="NA" /idTUdmin="U419" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(550685..550704) /Source="Nicolas_upshift_promotors" /id="U418" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.796203796203796" /psig="0.999000999001" /xcortree=1843 /SigmaFactorBS="tcctttcaacacattgcttgatcacattctttctcattgtaG TTGACAAtgaaatgaaaaaaACGTACATTCGGGCATGTACgtttgggcaattttcaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(550706) /Source="Nicolas_upshifts" /id="U418" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.796203796203796" /psig="0.999000999001" /xcortree=1843 /SigmaFactorBS="tcctttcaacacattgcttgatcacattctttctcattgtaG TTGACAAtgaaatgaaaaaaACGTACATTCGGGCATGTACgtttgggcaattttcaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(550718..550725) /Source="Nicolas_upshift_promotors" /id="U418" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.796203796203796" /psig="0.999000999001" /xcortree=1843 /SigmaFactorBS="tcctttcaacacattgcttgatcacattctttctcattgtaG TTGACAAtgaaatgaaaaaaACGTACATTCGGGCATGTACgtttgggcaattttcaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 550766..550771 /Source="Nicolas_upshift_promotors" /id="U419" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.833166833166833" /psig="0.833166833166833" /xcortree=1016 /SigmaFactorBS="actacaatgagaaagaatgtgatcaagcaatgtgttgaaagg AGATTAtcatgtcaaaaatgTTATATACATTAGGAGGATgggttgctcgcaatcgcat a" /listShort="ydfJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS 550774..552948 /gene="ydfJ" /locus_tag="BSU_05430" /old_locus_tag="BSU05430" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15941986; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative proton metabolite efflux transporter" /protein_id="NP_388424.1" /db_xref="EnsemblGenomes-Gn:BSU05430" /db_xref="EnsemblGenomes-Tr:CAB12350" /db_xref="GOA:P96687" /db_xref="InterPro:IPR000731" /db_xref="InterPro:IPR004869" /db_xref="SubtiList:BG12157" /db_xref="UniProtKB/Swiss-Prot:P96687" /translation="MSKMLYTLGGWVARNRIKAICAWIVVLVAAIGLAVTLKPSFSED MSIPDTPSEKAMDVIQKEFPHGPDKGSIRVIFGAGDGEKLTGKPAKKAIEDTFKEISK DDSVDSIASPFVTGTIAKDGTVAYADIQYKSSADDIKDYSIKHLKDSLKMADDEGLQT ELSGDVPGAEMEIGGVSEIVGIILAFVVLAITFGSLLIAGLPILTALIGLGVSIGLVL IGTQVFDIASVSLSLAGMIGLAVGIDYALFIFTKHRQFLGEGIQKNESIARAVGTAGS AVVFAGLTVIVALCGLTVVNIPFMSAMGLTAGLSVLMAVLASITLVPAVLSIAGKRMI PKSNKKIEKQSTETNVWGRFVTKNPIMLSVCSILILIVISIPSMHLELGLPDAGMKAK DNPDRRAYDLLAEGFGEGFNGQLTIVADATNATENKAEAFADAVKEIKGLDHVASVTP AMPNKEGNFAIITVVPETGPNDVTTKDLVHDVRSLSDKNGVDLLVTGSTAVNIDISDR LNDAIPVFAVLIVGFAFVLLTIVFRSLLVPLVAVAGFMLTMTATLGICVFVLQDGNLI DFFKIPEKGPILAFLPILSIGILFGLAMDYQVFLVSRMREEYVKTNNPVQAIQAGLKH SGPVVTAAGLIMIFVFAGFIFAGEASIKANGLALSFGVLFDAFIVRMTLIPSVMKLMG NAAWYLPKWLDKIIPNVDIEGHQLTKEIQPEIDHEQKKQISV*" /label="ydfJ CDS" gene 550774..552948 /gene="ydfJ" /locus_tag="BSU_05430" /old_locus_tag="BSU05430" /label="ydfJ gene" upshifts 550784 /Source="Nicolas_upshifts" /id="U419" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.833166833166833" /psig="0.833166833166833" /xcortree=1016 /SigmaFactorBS="actacaatgagaaagaatgtgatcaagcaatgtgttgaaagg AGATTAtcatgtcaaaaatgTTATATACATTAGGAGGATgggttgctcgcaatcgcat a" /listShort="ydfJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 550786..550804 /Source="Nicolas_upshift_promotors" /id="U419" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.833166833166833" /psig="0.833166833166833" /xcortree=1016 /SigmaFactorBS="actacaatgagaaagaatgtgatcaagcaatgtgttgaaagg AGATTAtcatgtcaaaaatgTTATATACATTAGGAGGATgggttgctcgcaatcgcat a" /listShort="ydfJ" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature complement(551850..551868) /Source="Nicolas_upshift_promotors" /id="U420" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.763236763236763" /psig="0.763236763236763" /xcortree=1205 /SigmaFactorBS="atgcatagatgggatactaatgacgatcaaaatcagaatgct GCATACACTTAGCATGATAggatttttggtgacaaagcgtccccagacatttgtttca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(551850) /Source="Nicolas_upshifts" /id="U420" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.763236763236763" /psig="0.763236763236763" /xcortree=1205 /SigmaFactorBS="atgcatagatgggatactaatgacgatcaaaatcagaatgct GCATACACTTAGCATGATAggatttttggtgacaaagcgtccccagacatttgtttca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(552952..553359) /Source="Nicolas_S_feature" /locus_tag="new_591895_592302_c" /HighExp="Paraq, H2O2, Oxctl, aero, LBGexp, dia15, GM 150, M/G, ferm, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S187" promotor_-35 552969..552973 /Source="Nicolas_upshift_promotors" /id="U421" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=3115 /SigmaFactorBS="aacaaaagaaacaaatcagtgtgtaatagaaaaagcagatct tttaTGATCtgctcttttgctTATGGTAGTATTTAGAAGATgaagtcggcagttaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 552983 /Source="Nicolas_upshifts" /id="U421" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=3115 /SigmaFactorBS="aacaaaagaaacaaatcagtgtgtaatagaaaaagcagatct tttaTGATCtgctcttttgctTATGGTAGTATTTAGAAGATgaagtcggcagttaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 552986..553005 /Source="Nicolas_upshift_promotors" /id="U421" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=3115 /SigmaFactorBS="aacaaaagaaacaaatcagtgtgtaatagaaaaagcagatct tttaTGATCtgctcttttgctTATGGTAGTATTTAGAAGATgaagtcggcagttaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(552997) /Source="Nicolas_upshifts" /id="D260" /incds=0 /nref=22 /ntot=134 /MaxReadThrough="-0.100210000000001" /MaxDrop="3.637" /score="4.29161871" /energy="-8.8" /TU="NA" /idTUdmin="U422" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS complement(553360..554262) /gene="cesA" /locus_tag="BSU_05440" /old_locus_tag="BSU05440" /EC_number="3.1.1.1" /function="16.8: Protect" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7765103, 22248594, 24418394" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7765103, 22248594, 24418394; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="carboxylesterase NP" /protein_id="NP_388425.1" /db_xref="EnsemblGenomes-Gn:BSU05440" /db_xref="EnsemblGenomes-Tr:CAB12351" /db_xref="GOA:P96688" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="PDB:2R11" /db_xref="SubtiList:BG11957" /db_xref="UniProtKB/Swiss-Prot:P96688" /translation="MSNHSSSIPELSDNGIRYYQTYNESLSLWPVRCKSFYISTRFGQ THVIASGPEDAPPLVLLHGALFSSTMWYPNIADWSSKYRTYAVDIIGDKNKSIPENVS GTRTDYANWLLDVFDNLGIEKSHMIGLSLGGLHTMNFLLRMPERVKSAAILSPAETFL PFHHDFYKYALGLTASNGVETFLNWMMNDQNVLHPIFVKQFKAGVMWQDGSRNPNPNA DGFPYVFTDEELRSARVPILLLLGEHEVIYDPHSALHRASSFVPDIEAEVIKNAGHVL SMEQPTYVNERVMRFFNAETGISR*" /label="cesA CDS" gene complement(553360..554262) /gene="cesA" /locus_tag="BSU_05440" /old_locus_tag="BSU05440" /label="cesA gene" S_feature complement(554263..554358) /Source="Nicolas_S_feature" /locus_tag="new_593206_593301_c" /HighExp="nit, ferm, aero, LoTm, M/G, GM 150, Diami, Paraq, dia15, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S188" promotor_-10 complement(554338..554357) /Source="Nicolas_upshift_promotors" /id="U422" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=2448 /SigmaFactorBS="tcaataatctgtttcaatcgtttttttccttttcatcttgGA TTTGACgtctaataacaacTGTATTATATTGTAAATAAAgtctgttatatcaaaatca g" /listShort="S188, nap, S187" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(554358) /Source="Nicolas_upshifts" /id="U422" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=2448 /SigmaFactorBS="tcaataatctgtttcaatcgtttttttccttttcatcttgGA TTTGACgtctaataacaacTGTATTATATTGTAAATAAAgtctgttatatcaaaatca g" /listShort="S188, nap, S187" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(554371..554378) /Source="Nicolas_upshift_promotors" /id="U422" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=2448 /SigmaFactorBS="tcaataatctgtttcaatcgtttttttccttttcatcttgGA TTTGACgtctaataacaacTGTATTATATTGTAAATAAAgtctgttatatcaaaatca g" /listShort="S188, nap, S187" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(554464..555153) /gene="ydfK" /locus_tag="BSU_05450" /old_locus_tag="BSU05450" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10200972, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388426.1" /db_xref="EnsemblGenomes-Gn:BSU05450" /db_xref="EnsemblGenomes-Tr:CAB12352" /db_xref="GOA:P96689" /db_xref="InterPro:IPR007563" /db_xref="SubtiList:BG12158" /db_xref="UniProtKB/Swiss-Prot:P96689" /translation="MFGTIFNTVMIIAGSIIGGIFKKGIKDEYQDILMQAMGFAAVAL GINAITQHLPDSKYPILFIVSLAIGGLLGQIINLELRFNKLVNKFSKSNLAEGLSTAV LLFCIGSLSILGPVEAALHGDYTYLLTNGMLDGITSIVLASTFGFGIAAAALVLFSWQ GSIYLFAQVMESAINTDLINEITIVGGILILSSGLSILGIKKFKTLNLLPSLLIPPVV IFVIHAFGLRF*" /label="ydfK CDS" gene complement(554464..555153) /gene="ydfK" /locus_tag="BSU_05450" /old_locus_tag="BSU05450" /label="ydfK gene" CDS complement(555243..556055) /gene="ydfL" /locus_tag="BSU_05460" /old_locus_tag="BSU05460" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator of efflux transporter" /protein_id="NP_388427.1" /db_xref="EnsemblGenomes-Gn:BSU05460" /db_xref="EnsemblGenomes-Tr:CAB12353" /db_xref="GOA:P96690" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="InterPro:IPR010499" /db_xref="InterPro:IPR011256" /db_xref="InterPro:IPR029442" /db_xref="SubtiList:BG12159" /db_xref="UniProtKB/Swiss-Prot:P96690" /translation="MKEFFSIGEVSKLFNVKISALRYYDEIGLLKPEYKDEQTNYRYY STQQFERLDTIKYLRALGLPINKLLDFYNSQNTNTLLHLLKSQQVEIDRKKKELERIE RKISRRITHIEDAVNMPLHQISKIKLPAMRVAYLQHEYVLGHDIEHSLAELRTHLNVN EDIFIGKIGLSISAANVKAKQFDKYSSIFMILEDENEKTSSEIIFPSREYLQIRFKGS HPEAEPYYKKLLAYMKEHHYEVAGDSIEITLIDYGITNNLDNYVTEILLPIK*" /label="ydfL CDS" gene complement(555243..556055) /gene="ydfL" /locus_tag="BSU_05460" /old_locus_tag="BSU05460" /label="ydfL gene" promotor_-10 complement(556084..556103) /Source="Nicolas_upshift_promotors" /id="U423" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=1898 /SigmaFactorBS="tttttagaaggagttttttctttatgctgcaAACTTTACctt tagtactcgccgTACTATATAATGTGTGTATAtcaatcataggacagaaaggttgtta g" /listShort="ydfL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(556097) /Source="Nicolas_upshifts" /id="U423" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=1898 /SigmaFactorBS="tttttagaaggagttttttctttatgctgcaAACTTTACctt tagtactcgccgTACTATATAATGTGTGTATAtcaatcataggacagaaaggttgtta g" /listShort="ydfL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(556119..556126) /Source="Nicolas_upshift_promotors" /id="U423" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=1898 /SigmaFactorBS="tttttagaaggagttttttctttatgctgcaAACTTTACctt tagtactcgccgTACTATATAATGTGTGTATAtcaatcataggacagaaaggttgtta g" /listShort="ydfL" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(556166..557059) /gene="mneP" /locus_tag="BSU_05470" /old_locus_tag="BSU05470" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:27748968" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 27748968; Product type t: transporter" /codon_start=1 /transl_table=11 /product="primary Mn(II) efflux pump" /protein_id="NP_388428.2" /db_xref="EnsemblGenomes-Gn:BSU05470" /db_xref="EnsemblGenomes-Tr:CAB12354" /db_xref="GOA:C0SP78" /db_xref="InterPro:IPR002524" /db_xref="InterPro:IPR027469" /db_xref="InterPro:IPR027470" /db_xref="InterPro:IPR036837" /db_xref="SubtiList:BG12160" /db_xref="UniProtKB/Swiss-Prot:C0SP78" /translation="MASEREQISRKVALIALIANLILMAGKVFFGLVGDSEAVFADGI HSAADVVASIAVLAVIGISNKPPDQDHPFGHGKAEVISEAIVGIILVIVSVYILIEAI LSFVKGPSVPQYSALFAALISYVAKEILYRYSIKQGKKWNSKAIIAIAYDHKGDIVAS LAAFIGVLLAIIGNSRGWSYLLYADAIASAIVAYLIFKISMELIRPSVDVLMEKSVDP ELIEEYKAVIFQCDQVKRIDRIRAREHGHYKLLDVRLSLDHDLTIKQGHDIAREIRNE IKRQFSDVEEVLIHVNPYFEE*" /label="mneP CDS" gene complement(556166..557059) /gene="mneP" /locus_tag="BSU_05470" /old_locus_tag="BSU05470" /label="mneP gene" downshifts complement(556186) /Source="Nicolas_upshifts" /id="D261" /incds=0 /nref=23 /ntot=121 /MaxReadThrough="1.07979" /MaxDrop="4.0938" /score="12.079524" /energy="-6.2" /TU="NA" /idTUdmin="U424" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" S_feature complement(557060..557152) /Source="Nicolas_S_feature" /locus_tag="new_596003_596095_c" /HighExp="LPh, HPh, LPhT, UNK1, MG t5, MG 5, MG 15, BMM, GM 120, Fru" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S189" promotor_-10 complement(557133..557152) /Source="Nicolas_upshift_promotors" /id="U424" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=1748 /SigmaFactorBS="caccttatttattagtaaacaggaaacaacgttgcTATAGAC CcactcgaaattgaatTGGTATGATAAACAAAGTGAttacacaggaaaggatacggag a" /listShort="S189, ydfM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(557150) /Source="Nicolas_upshifts" /id="U424" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=1748 /SigmaFactorBS="caccttatttattagtaaacaggaaacaacgttgcTATAGAC CcactcgaaattgaatTGGTATGATAAACAAAGTGAttacacaggaaaggatacggag a" /listShort="S189, ydfM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(557168..557175) /Source="Nicolas_upshift_promotors" /id="U424" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=1748 /SigmaFactorBS="caccttatttattagtaaacaggaaacaacgttgcTATAGAC CcactcgaaattgaatTGGTATGATAAACAAAGTGAttacacaggaaaggatacggag a" /listShort="S189, ydfM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 557341..557348 /Source="Nicolas_upshift_promotors" /id="U425" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=3024 /SigmaFactorBS="agtgaaaaatttccacctaattttcaaaaaccTATTGACAtg agaagatctgtaTTTTACTATTATCTCATATTcaagatattttaatttgagatatttg g" /listShort="ydfN, ydfO, S190, ydfP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 557363..557382 /Source="Nicolas_upshift_promotors" /id="U425" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=3024 /SigmaFactorBS="agtgaaaaatttccacctaattttcaaaaaccTATTGACAtg agaagatctgtaTTTTACTATTATCTCATATTcaagatattttaatttgagatatttg g" /listShort="ydfN, ydfO, S190, ydfP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 557369 /Source="Nicolas_upshifts" /id="U425" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=3024 /SigmaFactorBS="agtgaaaaatttccacctaattttcaaaaaccTATTGACAtg agaagatctgtaTTTTACTATTATCTCATATTcaagatattttaatttgagatatttg g" /listShort="ydfN, ydfO, S190, ydfP" /GFF_Attribute="listLong" /label="upshifts" CDS 557535..558155 /gene="ydfN" /locus_tag="BSU_05480" /old_locus_tag="BSU05480" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17407181; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388429.1" /db_xref="EnsemblGenomes-Gn:BSU05480" /db_xref="EnsemblGenomes-Tr:CAB12355" /db_xref="GOA:P96692" /db_xref="InterPro:IPR000415" /db_xref="InterPro:IPR029479" /db_xref="PDB:3BEM" /db_xref="SubtiList:BG12161" /db_xref="UniProtKB/Swiss-Prot:P96692" /translation="MAEFTHLVNERRSASNFLSGHPITKEDLNEMFELVALAPSAFNL QHTKYVTVLDQDVKEKLKQAANGQYKVVSSSAVLLVLGDKQAYQQAADIYEGLKVLGI LNKQEYDHMVQDTVSFYENRGEQFKRDEAIRNASLSAMMFMLSAKEKGWDTCPMIGFD AEAVKRILNIDDQFEVVMMITIGKEKTESRRPRGYRKPVNEFVEYM*" /label="ydfN CDS" gene 557535..558155 /gene="ydfN" /locus_tag="BSU_05480" /old_locus_tag="BSU05480" /label="ydfN gene" promotor_-35 557879..557885 /Source="Nicolas_upshift_promotors" /id="U426" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=151 /SigmaFactorBS="tattggggatattaaataagcaagagtatgaccacatggtgc aagacacCGTTTCGttttatgaaaacaGGGGAGAACAATTTAAGAGagatgaggcgat a" /listShort="ydfO, S190, ydfP" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 557890 /Source="Nicolas_upshifts" /id="U426" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=151 /SigmaFactorBS="tattggggatattaaataagcaagagtatgaccacatggtgc aagacacCGTTTCGttttatgaaaacaGGGGAGAACAATTTAAGAGagatgaggcgat a" /listShort="ydfO, S190, ydfP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 557899..557917 /Source="Nicolas_upshift_promotors" /id="U426" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=151 /SigmaFactorBS="tattggggatattaaataagcaagagtatgaccacatggtgc aagacacCGTTTCGttttatgaaaacaGGGGAGAACAATTTAAGAGagatgaggcgat a" /listShort="ydfO, S190, ydfP" /GFF_Attribute="listLong" /label="promotor_-10" CDS 558171..559109 /gene="ydfO" /locus_tag="BSU_05490" /old_locus_tag="BSU05490" /EC_number="1.13.11.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17407181; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dioxygenase" /protein_id="NP_388430.1" /db_xref="EnsemblGenomes-Gn:BSU05490" /db_xref="EnsemblGenomes-Tr:CAB12356" /db_xref="GOA:P96693" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="PDB:3OAJ" /db_xref="SubtiList:BG12162" /db_xref="UniProtKB/Swiss-Prot:P96693" /translation="MAKKTMGIHHITAIVGHPQENTDFYAGVLGLRLVKQTVNFDDPG TYHLYFGNEGGKPGTIITFFPWAGARQGVIGDGQVGVTSYVVPKGAMAFWEKRLEKFN VPYTKIERFGEQYVEFDDPHGLHLEIVEREEGEANTWTFGEVTPDVAIKGFGGATLLS EQPDKTADLLENIMGLERVGKEGDFVRYRSAGDIGNVIDLKLTPIGRGQMGAGTVHHI AWRANDDEDQLDWQRYIASHGYGVTPVRDRNYFNAIYFREHGEILFEIATDPPGFAHD ETQETMGEKLMLPVQYEPHRTQIEQGLLPFEVRELD*" /label="ydfO CDS" gene 558171..559109 /gene="ydfO" /locus_tag="BSU_05490" /old_locus_tag="BSU05490" /label="ydfO gene" promotor_-35 559097..559100 /Source="Nicolas_upshift_promotors" /id="U427" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.658341658341658" /psig="0.658341658341658" /xcortree=729 /SigmaFactorBS="caaattgaacaagggctgctgccgtttgaagtaagAGAGtta gattgatttgaCACATAAAAAATAAAGAAACatatattcaattgatgattgctggatg g" /listShort="S190, ydfP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 559115..559134 /Source="Nicolas_upshift_promotors" /id="U427" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.658341658341658" /psig="0.658341658341658" /xcortree=729 /SigmaFactorBS="caaattgaacaagggctgctgccgtttgaagtaagAGAGtta gattgatttgaCACATAAAAAATAAAGAAACatatattcaattgatgattgctggatg g" /listShort="S190, ydfP" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 559122..559210 /Source="Nicolas_S_feature" /locus_tag="new_598065_598153" /HighExp="Etha, BT, S6, S7, S8, G/S, GM 10, Gly, GM 15, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigB, SigA" /TUshortPSig="0.658, 0.993, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S190" upshifts 559122 /Source="Nicolas_upshifts" /id="U427" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.658341658341658" /psig="0.658341658341658" /xcortree=729 /SigmaFactorBS="caaattgaacaagggctgctgccgtttgaagtaagAGAGtta gattgatttgaCACATAAAAAATAAAGAAACatatattcaattgatgattgctggatg g" /listShort="S190, ydfP" /GFF_Attribute="listLong" /label="upshifts" CDS 559211..559600 /gene="ydfP" /locus_tag="BSU_05500" /old_locus_tag="BSU05500" /EC_number="1.-.-.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15306018, 15849754, 16850406, 17407181; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane bound oxidoreductase" /protein_id="NP_388431.1" /db_xref="EnsemblGenomes-Gn:BSU05500" /db_xref="EnsemblGenomes-Tr:CAB12357" /db_xref="GOA:P96694" /db_xref="InterPro:IPR032808" /db_xref="SubtiList:BG12163" /db_xref="UniProtKB/Swiss-Prot:P96694" /translation="MEDAGLLLIRIMIGVVFLFYGTQKLFGWFGGYGIKGTGQWFESI GVKPGNVAAALSGLGELVSGILFILGVFLPLGAAIITIIMLGAIVKVHGAKGFANGAG GFEYNLVLIAVSIGVALIGSGAYALHF*" /label="ydfP CDS" gene 559211..559600 /gene="ydfP" /locus_tag="BSU_05500" /old_locus_tag="BSU05500" /label="ydfP gene" downshifts 559591 /Source="Nicolas_upshifts" /id="D262" /incds=0 /nref=3 /ntot=91 /MaxReadThrough="1.0642" /MaxDrop="3.85597" /score="-8.69038499" /energy="-9.3" /TU="NA" /idTUdmin="U427" /TUdmin=29 /isTUend="FALSE" /label="downshifts" misc_feature 559714..559733 /Source="Nicolas_upshift_promotors" /id="U428" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.665334665334665" /psig="0.946053946053946" /xcortree=2048 /SigmaFactorBS="cattttcggcaagcttgcaggtactctgcaaagcaaaaaagc ggatatcataaatataAATCTGTATAGTGAATGATAcgtattgatgagcttggtcatg a" /listShort="S191, ydfQ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 559716..559785 /Source="Nicolas_S_feature" /locus_tag="new_598659_598728" /HighExp="Diami, dia5, H2O2, dia15, Etha, S8, Paraq, Salt, LPhT, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.946" /TUlongSig="NA" /TUlongPSig="NA" /label="S191" upshifts 559716 /Source="Nicolas_upshifts" /id="U428" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.665334665334665" /psig="0.946053946053946" /xcortree=2048 /SigmaFactorBS="cattttcggcaagcttgcaggtactctgcaaagcaaaaaagc ggatatcataaatataAATCTGTATAGTGAATGATAcgtattgatgagcttggtcatg a" /listShort="S191, ydfQ" /GFF_Attribute="listLong" /label="upshifts" CDS 559786..560124 /gene="ydfQ" /locus_tag="BSU_05510" /old_locus_tag="BSU05510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15937154; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thioredoxin or thiol-disulfide isomerase" /protein_id="NP_388432.1" /db_xref="EnsemblGenomes-Gn:BSU05510" /db_xref="EnsemblGenomes-Tr:CAB12358" /db_xref="GOA:P96695" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG12164" /db_xref="UniProtKB/Swiss-Prot:P96695" /translation="MKEMTGLHSLVSIENFIKQHKFSFIYISRPGCTVCHAVLPQLRI VLDQFPNIKLGHINADDVAEVAGRFSVFTVPVLLLFIDGTEFLREARFVHFEQLEQKL KRVYRLYEGE*" /label="ydfQ CDS" gene 559786..560124 /gene="ydfQ" /locus_tag="BSU_05510" /old_locus_tag="BSU05510" /label="ydfQ gene" downshifts 560112 /Source="Nicolas_upshifts" /id="D263" /incds=0 /nref=9 /ntot=28 /MaxReadThrough="1.76745" /MaxDrop="4.78737" /score="17.861178" /energy="-6" /TU="NA" /idTUdmin="U428" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(560164..560400) /gene="ydzH" /locus_tag="BSU_05520" /old_locus_tag="BSU05520" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein, sporulation-related" /protein_id="NP_388433.1" /db_xref="EnsemblGenomes-Gn:BSU05520" /db_xref="EnsemblGenomes-Tr:CAB12359" /db_xref="InterPro:IPR019618" /db_xref="SubtiList:BG12810" /db_xref="UniProtKB/Swiss-Prot:O31496" /translation="MRSQINISNLTINGMTQNANTDIGQNLQNSHTANSKNYGVNFTL GDYSPSHSIIISASCDNDTSDQGQVDNPSSPSEE*" /label="ydzH CDS" gene complement(560164..560400) /gene="ydzH" /locus_tag="BSU_05520" /old_locus_tag="BSU05520" /label="ydzH gene" downshifts complement(560188) /Source="Nicolas_upshifts" /id="D264" /incds=0 /nref=1 /ntot=10 /MaxReadThrough="3.87679" /MaxDrop="2.5881" /score="9.38580075" /energy="-6" /TU="NA" /idTUdmin="U430" /TUdmin=418 /isTUend="FALSE" /label="downshifts" promotor_-35 560212..560218 /Source="Nicolas_upshift_promotors" /id="U429" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.722277722277722" /psig="0.722277722277722" /xcortree=1208 /SigmaFactorBS="aagggttatcaacctgcccttgatcactTGTATCAttatcac aacttgcTGAAATAATAATtgaatgagaaggagagtaatctcctaatgtgaaattcac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 560233..560244 /Source="Nicolas_upshift_promotors" /id="U429" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.722277722277722" /psig="0.722277722277722" /xcortree=1208 /SigmaFactorBS="aagggttatcaacctgcccttgatcactTGTATCAttatcac aacttgcTGAAATAATAATtgaatgagaaggagagtaatctcctaatgtgaaattcac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 560244 /Source="Nicolas_upshifts" /id="U429" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.722277722277722" /psig="0.722277722277722" /xcortree=1208 /SigmaFactorBS="aagggttatcaacctgcccttgatcactTGTATCAttatcac aacttgcTGAAATAATAATtgaatgagaaggagagtaatctcctaatgtgaaattcac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(560401..560562) /Source="Nicolas_S_feature" /locus_tag="new_599344_599505_c" /HighExp="BT, B36, S8, S7, G135, S5, S6, G180, Pyr, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S192" S_feature complement(560566..560931) /Source="Nicolas_S_feature" /locus_tag="new_599509_599874_c" /HighExp="BT, B36, S8, S7, S6, G/S, S5, Pyr, B60, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigGF, SigK" /TUshortPSig="0.994, 0.989, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S193" downshifts complement(560606) /Source="Nicolas_upshifts" /id="D265" /incds=0 /nref=26 /ntot=52 /MaxReadThrough="2.64253" /MaxDrop="4.6761" /score="8.29803249" /energy="-12.4" /TU="NA" /idTUdmin="U430" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(560932..561162) /gene="ydzR" /locus_tag="BSU_05529" /old_locus_tag="BSU05529" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 19383706, 20709900" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein, sporulation-related" /protein_id="YP_003097687.1" /db_xref="EnsemblGenomes-Gn:BSU05529" /db_xref="EnsemblGenomes-Tr:CAX52560" /db_xref="InterPro:IPR019618" /db_xref="UniProtKB/Swiss-Prot:C0H3W2" /translation="MMKFPVYIHSISGNSVFNNGFAVSISPFSVSKTTEGSGGSNTGL VFESNALSQTSSANQAQNVTYAIQELLSKLLA*" /label="ydzR CDS" gene complement(560932..561162) /gene="ydzR" /locus_tag="BSU_05529" /old_locus_tag="BSU05529" /label="ydzR gene" downshifts 561146 /Source="Nicolas_upshifts" /id="D266" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="1.08051" /MaxDrop="3.36374" /score="17.861178" /energy="-6" /TU="NA" /idTUdmin="U428" /TUdmin=1034 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(561183..561202) /Source="Nicolas_upshift_promotors" /id="U430" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1432 /SigmaFactorBS="ggtttttgtctcttactgaaagtttttgccgttttGTTTAAG CAActgctgctcacacACCATATTGTATAAACAGTCataacagagaggagagatgaat g" /listShort="ydzR, S193" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(561200) /Source="Nicolas_upshifts" /id="U430" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1432 /SigmaFactorBS="ggtttttgtctcttactgaaagtttttgccgttttGTTTAAG CAActgctgctcacacACCATATTGTATAAACAGTCataacagagaggagagatgaat g" /listShort="ydzR, S193" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(561202..561285) /Source="Nicolas_S_feature" /locus_tag="new_600145_600228_c" /HighExp="S8, S5, S7, S6, S4, nit, ferm, BT, Pyr, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigK" /TUshortPSig="0.989, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S194" promotor_-35 complement(561216..561225) /Source="Nicolas_upshift_promotors" /id="U430" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1432 /SigmaFactorBS="ggtttttgtctcttactgaaagtttttgccgttttGTTTAAG CAActgctgctcacacACCATATTGTATAAACAGTCataacagagaggagagatgaat g" /listShort="ydzR, S193" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(561286..561963) /gene="ydfR" /locus_tag="BSU_05530" /old_locus_tag="BSU05530" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_388434.1" /db_xref="EnsemblGenomes-Gn:BSU05530" /db_xref="EnsemblGenomes-Tr:CAB12360" /db_xref="GOA:P96696" /db_xref="InterPro:IPR007353" /db_xref="InterPro:IPR023090" /db_xref="SubtiList:BG12165" /db_xref="UniProtKB/Swiss-Prot:P96696" /translation="MNRLPFGYIKLRLAGRKANPMTNLIHHWSGGSMNFTWESLVLIV AGVILLRISGRKSIAQMTSTQTVVMISIGTIIVQPIIEYSLFKTLIAAAIFTSTLIVM EWIQMKSNTIEKMLTGKAKIVIENGQLHIENLKKMRLTADQLEMQLRLHGVTAIQDVK IATLEANGQLGIELTDDAKPLTVRDLKKLIHPDFINKDGQAQSGNQNIFDEVGKKNKK NVPKKLH*" /label="ydfR CDS" gene complement(561286..561963) /gene="ydfR" /locus_tag="BSU_05530" /old_locus_tag="BSU05530" /label="ydfR gene" promotor_-10 complement(561934..561945) /Source="Nicolas_upshift_promotors" /id="U431" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=782 /SigmaFactorBS="taatatatccatctataccaaaaatattgttcggttcaggac AGAATGAaccgactgcctttcGGATATATTAAAttgcgattggccggaagaaaagcca a" /listShort="ydfR, S194, ydzR, S193" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(561948) /Source="Nicolas_upshifts" /id="U431" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=782 /SigmaFactorBS="taatatatccatctataccaaaaatattgttcggttcaggac AGAATGAaccgactgcctttcGGATATATTAAAttgcgattggccggaagaaaagcca a" /listShort="ydfR, S194, ydzR, S193" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(561960..561966) /Source="Nicolas_upshift_promotors" /id="U431" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=782 /SigmaFactorBS="taatatatccatctataccaaaaatattgttcggttcaggac AGAATGAaccgactgcctttcGGATATATTAAAttgcgattggccggaagaaaagcca a" /listShort="ydfR, S194, ydzR, S193" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(561964..562797) /Source="Nicolas_S_feature" /locus_tag="new_600907_601740_c" /HighExp="S6, S8, S7, S5, BT, B36, G/S, Pyr, nit, B60" /AntisenseName="ydfS" /AntisenseCor="0.65823831974361602" /AntisenseRegPval="-34.1" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S195" promotor_-35 561979..561984 /Source="Nicolas_upshift_promotors" /id="U432" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.944055944055944" /psig="0.944055944055944" /xcortree=781 /SigmaFactorBS="ccgaaaggcagtcggttcattctgtcctgaaccgaACAATAt ttttggtatagatGGATATATTAAGccaaacaatgatagcaacaggagttttttggcc g" /listShort="ydfS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 561999..562010 /Source="Nicolas_upshift_promotors" /id="U432" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.944055944055944" /psig="0.944055944055944" /xcortree=781 /SigmaFactorBS="ccgaaaggcagtcggttcattctgtcctgaaccgaACAATAt ttttggtatagatGGATATATTAAGccaaacaatgatagcaacaggagttttttggcc g" /listShort="ydfS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 562004 /Source="Nicolas_upshifts" /id="U432" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.944055944055944" /psig="0.944055944055944" /xcortree=781 /SigmaFactorBS="ccgaaaggcagtcggttcattctgtcctgaaccgaACAATAt ttttggtatagatGGATATATTAAGccaaacaatgatagcaacaggagttttttggcc g" /listShort="ydfS" /GFF_Attribute="listLong" /label="upshifts" CDS 562076..562783 /gene="ydfS" /locus_tag="BSU_05540" /old_locus_tag="BSU05540" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388435.1" /db_xref="EnsemblGenomes-Gn:BSU05540" /db_xref="EnsemblGenomes-Tr:CAB12361" /db_xref="GOA:P96697" /db_xref="InterPro:IPR007353" /db_xref="InterPro:IPR023090" /db_xref="SubtiList:BG12166" /db_xref="UniProtKB/Swiss-Prot:P96697" /translation="MIELEVVIRTVASFGLLLIAERILGKQTISQMTIFDFIAAITLG AIAAGLAYNTSIKPHNMAISFSIFVLTIFLISFLSIKNRKLRKFFAGDPTVLIQNGKI LESNMRKMRYTLDYLNQQLREKEIFNIEEVLFAILETNGQLTVLRKPQFRHVTKQDLM IAVNQEQRLPIELIMDGEIIENNLKQNRLTESWLLEELRKRDIKVKETVYAVLLGNGD IYVDQYKDHISVPMDKE*" /label="ydfS CDS" gene 562076..562783 /gene="ydfS" /locus_tag="BSU_05540" /old_locus_tag="BSU05540" /label="ydfS gene" CDS complement(562798..563229) /gene="cotP" /locus_tag="BSU_05550" /old_locus_tag="BSU05550" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11150673" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11150673; Product type s: structure" /codon_start=1 /transl_table=11 /product="spore coat protein" /protein_id="NP_388436.1" /db_xref="EnsemblGenomes-Gn:BSU05550" /db_xref="EnsemblGenomes-Tr:CAB12362" /db_xref="GOA:P96698" /db_xref="InterPro:IPR002068" /db_xref="InterPro:IPR008978" /db_xref="InterPro:IPR031107" /db_xref="SubtiList:BG12167" /db_xref="UniProtKB/Swiss-Prot:P96698" /translation="MDFEKIRKWLEITNEYKQSDFWTNVLKYKAPEHFFDSEASTFVY DFYQDEEYNFIIVEMPGVYEEELTIRLLSKTQLLIKGTITPVFPAEMEVLRERYYGEI ERIIQLPEAAETHLLQIQLLNGLLHISYPRQVETVAFNKGL*" /label="cotP CDS" gene complement(562798..563229) /gene="cotP" /locus_tag="BSU_05550" /old_locus_tag="BSU05550" /label="cotP gene" CDS complement(563242..563484) /gene="ydgA" /locus_tag="BSU_05560" /old_locus_tag="BSU05560" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; putative germination protein" /protein_id="NP_388437.1" /db_xref="EnsemblGenomes-Gn:BSU05560" /db_xref="EnsemblGenomes-Tr:CAB12363" /db_xref="InterPro:IPR019618" /db_xref="SubtiList:BG12168" /db_xref="UniProtKB/Swiss-Prot:P96699" /translation="MPYQINIANIKINGVTQNGNIDVGPTVHNSHTANSKYFGANFSL GDLSPTSSLLNTGNIDSDVSDQDQIGNPSAPISNQI*" /label="ydgA CDS" gene complement(563242..563484) /gene="ydgA" /locus_tag="BSU_05560" /old_locus_tag="BSU05560" /label="ydgA gene" CDS complement(563498..563770) /gene="ydgB" /locus_tag="BSU_05570" /old_locus_tag="BSU05570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; putative germination protein" /protein_id="NP_388438.1" /db_xref="EnsemblGenomes-Gn:BSU05570" /db_xref="EnsemblGenomes-Tr:CAB12364" /db_xref="InterPro:IPR019618" /db_xref="SubtiList:BG12169" /db_xref="UniProtKB/Swiss-Prot:P96700" /translation="MPSTVINLYYLKINSISGNGSITIGEAAYNSPTNNQKSQGTNSS FGDTSPTESVMENFLNDPDVNDQTSIGNSDTSNVNAPPIAPPPILD*" /label="ydgB CDS" gene complement(563498..563770) /gene="ydgB" /locus_tag="BSU_05570" /old_locus_tag="BSU05570" /label="ydgB gene" promotor_-10 complement(563792..563811) /Source="Nicolas_upshift_promotors" /id="U433" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1305 /SigmaFactorBS="gatagagttttgcccgtaaatgCAAGGAACAAttgggtgcag cggCGCATAATGTACTGTACAGAaagatggaagggtgtgatgggatgccgtctacagt a" /listShort="ydgB, ydgA, cotP, S195, ydfR, S194, ydzR, S193" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(563796) /Source="Nicolas_upshifts" /id="U433" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1305 /SigmaFactorBS="gatagagttttgcccgtaaatgCAAGGAACAAttgggtgcag cggCGCATAATGTACTGTACAGAaagatggaagggtgtgatgggatgccgtctacagt a" /listShort="ydgB, ydgA, cotP, S195, ydfR, S194, ydzR, S193" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(563825..563834) /Source="Nicolas_upshift_promotors" /id="U433" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1305 /SigmaFactorBS="gatagagttttgcccgtaaatgCAAGGAACAAttgggtgcag cggCGCATAATGTACTGTACAGAaagatggaagggtgtgatgggatgccgtctacagt a" /listShort="ydgB, ydgA, cotP, S195, ydfR, S194, ydzR, S193" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 563989..563996 /Source="Nicolas_upshift_promotors" /id="U434" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.786213786213786" /psig="0.997002997002997" /xcortree=1917 /SigmaFactorBS="gaagctggcaaacaggatcagtttgaaatAATTGACAatgaa gctaatgccaTGAAATAATACTCGTGAGTAacattactcgtgggtattatttttgggg t" /listShort="ydgC, ydgD, S196, ydgE, S197" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 564012..564031 /Source="Nicolas_upshift_promotors" /id="U434" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.786213786213786" /psig="0.997002997002997" /xcortree=1917 /SigmaFactorBS="gaagctggcaaacaggatcagtttgaaatAATTGACAatgaa gctaatgccaTGAAATAATACTCGTGAGTAacattactcgtgggtattatttttgggg t" /listShort="ydgC, ydgD, S196, ydgE, S197" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 564020 /Source="Nicolas_upshifts" /id="U434" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.786213786213786" /psig="0.997002997002997" /xcortree=1917 /SigmaFactorBS="gaagctggcaaacaggatcagtttgaaatAATTGACAatgaa gctaatgccaTGAAATAATACTCGTGAGTAacattactcgtgggtattatttttgggg t" /listShort="ydgC, ydgD, S196, ydgE, S197" /GFF_Attribute="listLong" /label="upshifts" CDS 564069..564656 /gene="ydgC" /locus_tag="BSU_05580" /old_locus_tag="BSU05580" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_388439.1" /db_xref="EnsemblGenomes-Gn:BSU05580" /db_xref="EnsemblGenomes-Tr:CAB12365" /db_xref="GOA:P96701" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG12170" /db_xref="UniProtKB/Swiss-Prot:P96701" /translation="MKSKGVESRKRLLKAAANEFSVRGFHDAKVSEIVKKAGFTQPSF YLYFQSKEAIFAELITDFHSRVRKLTESLLLENGLNTEDVSKRVLLAVETVFQFLDED KDLTKIGFFLNPEAKQMKKDLAMVLKENLEAEQRLGYFHSELDMETVAECLVGMIEHL TESFLLTGIKDPASLAAEVVNLLIYGMLPKGNDVR*" /label="ydgC CDS" gene 564069..564656 /gene="ydgC" /locus_tag="BSU_05580" /old_locus_tag="BSU05580" /label="ydgC gene" CDS 564653..564997 /gene="ydgD" /locus_tag="BSU_05590" /old_locus_tag="BSU05590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388440.1" /db_xref="EnsemblGenomes-Gn:BSU05590" /db_xref="EnsemblGenomes-Tr:CAB12366" /db_xref="GOA:P96702" /db_xref="InterPro:IPR032808" /db_xref="SubtiList:BG12171" /db_xref="UniProtKB/Swiss-Prot:P96702" /translation="MISIMMKVSLAVFMLAGGIIKVSRVPFQVEHWRHYQYPLWFLTV TGILEIAGALAMTAGIWNRYAAIGAGVLFVVLMAGAIHAHMFRARQSVIMAIQAMICL IVSIMIIMGSYT*" /label="ydgD CDS" gene 564653..564997 /gene="ydgD" /locus_tag="BSU_05590" /old_locus_tag="BSU05590" /label="ydgD gene" S_feature 564998..565159 /Source="Nicolas_S_feature" /locus_tag="new_603941_604102" /HighExp="Salt, Diami, dia15, dia5, aero, H2O2, SMMPr, Etha, Lbtran, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S196" CDS 565160..565633 /gene="ydgE" /locus_tag="BSU_05600" /old_locus_tag="BSU05600" /EC_number="2.3.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_388441.1" /db_xref="EnsemblGenomes-Gn:BSU05600" /db_xref="EnsemblGenomes-Tr:CAB12367" /db_xref="GOA:P96703" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG12172" /db_xref="UniProtKB/Swiss-Prot:P96703" /translation="MAFTLEDMTEEEFEAFRGMSVQNFAKQNITSGTWTEKEAFEKSE QAYENMIPNGRDSSNHYFWNITNDQGERMGWLWLYADPLHPQKEAFIYSFGLYEAFRG KGLAQLALQTLDERARELGAERLALHVFAHNETAVYLYQKMGYAMTNIRMRKQLC*" /label="ydgE CDS" gene 565160..565633 /gene="ydgE" /locus_tag="BSU_05600" /old_locus_tag="BSU05600" /label="ydgE gene" S_feature 565634..566326 /Source="Nicolas_S_feature" /locus_tag="new_604577_605269" /HighExp="Salt, H2O2, dia15, aero, T-2.40H, Diami, T-3.40H, T-1.40H, T-4.40H, T-0.40H" /AntisenseName="vmlR" /AntisenseCor="-7.1224465259194999E-2" /AntisenseRegPval="-0.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S197" downshifts complement(565776) /Source="Nicolas_upshifts" /id="D267" /incds=0 /nref=4 /ntot=88 /MaxReadThrough="0.39199" /MaxDrop="3.39645" /score="18.2783449" /energy="-8.8" /TU="NA" /idTUdmin="U436" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(565793..567436) /gene="vmlR" /locus_tag="BSU_05610" /old_locus_tag="BSU05610" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16109936, 22226636, 24687494, 25891423" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16109936, 22226636, 24687494, 25891423; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ATP-binding cassette efflux transporter" /protein_id="NP_388442.1" /db_xref="EnsemblGenomes-Gn:BSU05610" /db_xref="EnsemblGenomes-Tr:CAB12368" /db_xref="GOA:P39115" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032781" /db_xref="SubtiList:BG10767" /db_xref="UniProtKB/Swiss-Prot:P39115" /translation="MKEIVTLTNVSYEVKDQTVFKHVNASVQQGDIIGIIGKNGAGKS TLLHLIHNDLAPAQGQILRKDIKLALVEQETAAYSFADQTPAEKKLLEKWHVPLRDFH QLSGGEKLKARLAKGLSEDADLLLLDEPTNHLDEKSLQFLIQQLKHYNGTVILVSHDR YFLDEAATKIWSLEDQTLIEFKGNYSGYMKFREKKRLTQQREYEKQQKMVERIEAQMN GLASWSEKAHAQSTKKEGFKEYHRVKAKRTDAQIKSKQKRLEKELEKAKAEPVTPEYT VRFSIDTTHKTGKRFLEVQNVTKAFGERTLFKNANFTIQHGEKVAIIGPNGSGKTTLL NIILGQETAEGSVWVSPSANIGYLTQEVFDLPLEQTPEELFENETFKARGHVQNLMRH LGFTAAQWTEPIKHMSMGERVKIKLMAYILEEKDVLILDEPTNHLDLPSREQLEETLS QYSGTLLAVSHDRYFLEKTTNSKLVISNNGIEKQLNDVPSERNEREELRLKLETERQE VLGKLSFMTPNDKGYKELDQAFNELTKRIKELDHQDKKD*" /label="vmlR CDS" gene complement(565793..567436) /gene="vmlR" /locus_tag="BSU_05610" /old_locus_tag="BSU05610" /label="vmlR gene" S_feature complement(567471..567668) /Source="Nicolas_S_feature" /locus_tag="new_606414_606611_c" /HighExp="BC, Sw, B60, B36, LoTm, S7, HiOs, S4, BI, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S198" promotor_-35 567485..567487 /Source="Nicolas_upshift_promotors" /id="U435" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.433566433566434" /psig="0.494505494505494" /xcortree=34 /SigmaFactorBS="gctttaaagggagaataaaaaaatcctcccaaatgtgTTGga aggattagccgtgcCTGTGCATGATCAAATAAGctattttttataaatagcagtgtcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 567504..567522 /Source="Nicolas_upshift_promotors" /id="U435" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.433566433566434" /psig="0.494505494505494" /xcortree=34 /SigmaFactorBS="gctttaaagggagaataaaaaaatcctcccaaatgtgTTGga aggattagccgtgcCTGTGCATGATCAAATAAGctattttttataaatagcagtgtcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 567508 /Source="Nicolas_upshifts" /id="U435" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.433566433566434" /psig="0.494505494505494" /xcortree=34 /SigmaFactorBS="gctttaaagggagaataaaaaaatcctcccaaatgtgTTGga aggattagccgtgcCTGTGCATGATCAAATAAGctattttttataaatagcagtgtcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(567514) /Source="Nicolas_upshifts" /id="D268" /incds=0 /nref=210 /ntot=265 /MaxReadThrough="3.59768" /MaxDrop="6.27457" /score="29.5863709" /energy="-11.8" /TU="U436" /idTUdmin="U437" /TUdmin=242 /isTUend="FALSE" /label="downshifts" downshifts 567634 /Source="Nicolas_upshifts" /id="D269" /incds=0 /nref=35 /ntot=150 /MaxReadThrough="1.71902" /MaxDrop="4.95368" /score="-7.23582918" /energy="-13.3" /TU="NA" /idTUdmin="U435" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(567660..567679) /Source="Nicolas_upshift_promotors" /id="U436" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.717282717282717" /psig=1 /xcortree=414 /SigmaFactorBS="atgagagcaggagtttttttgatgaaaatgaccTTTGCTTTt gaatttaaaggTATGCTATAGTGTTTGTAATcaaaacaagaagggatgatgggtggac a" /listShort="S198, vmlR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(567672) /Source="Nicolas_upshifts" /id="U436" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.717282717282717" /psig=1 /xcortree=414 /SigmaFactorBS="atgagagcaggagtttttttgatgaaaatgaccTTTGCTTTt gaatttaaaggTATGCTATAGTGTTTGTAATcaaaacaagaagggatgatgggtggac a" /listShort="S198, vmlR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(567692..567699) /Source="Nicolas_upshift_promotors" /id="U436" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.717282717282717" /psig=1 /xcortree=414 /SigmaFactorBS="atgagagcaggagtttttttgatgaaaatgaccTTTGCTTTt gaatttaaaggTATGCTATAGTGTTTGTAATcaaaacaagaagggatgatgggtggac a" /listShort="S198, vmlR" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(567755) /Source="Nicolas_upshifts" /id="D270" /incds=0 /nref=92 /ntot=203 /MaxReadThrough="2.22553" /MaxDrop="5.71399" /score="18.9878298" /energy="-13.3" /TU="NA" /idTUdmin="U437" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(567756..569132) /gene="ydgF" /locus_tag="BSU_05620" /old_locus_tag="BSU05620" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16109936, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative amino acid permease" /protein_id="NP_388443.1" /db_xref="EnsemblGenomes-Gn:BSU05620" /db_xref="EnsemblGenomes-Tr:CAB12369" /db_xref="GOA:P96704" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG12173" /db_xref="UniProtKB/Swiss-Prot:P96704" /translation="MTDDMTKDNINQQTLQRGLKNRHIQLIAIGGAIGTGLFLGSGKS IHFAGPSILFAYMITGIICFLIMRSLGELLLSNLNYHSFVDFVQDYLGDMAAFITGWT YWFCWISIAMADLTAVGLYTQYWLPGVPQWVPGLIALIILLIMNLATVKLFGELEFWF ALIKVIAILALIVIGLVMIFKGFSTSSGVSSFTNLWSHGGLFPNGMHGFILSFQMVVF AFVGIELVGLTAGETENPEKVIPKAINNIPVRVLLFYIGALLVIMSIYPWDIINPSES PFVQVFVAVGIVGAASIINFVVLTSAASACNSAVFSTSRMVYSLAKDHNAPESMAKLT QRKVPRNALFFSAIVILIGVTLNYIMPEGVFTLITSISTVCFIYIWGITVICHMKYRK TRPELAKTNKFKLPLYPFTNYLILAFLAFVLVVLALAQDTRVSLFVTPVWFILLIVIY KVRKAKHQ*" /label="ydgF CDS" gene complement(567756..569132) /gene="ydgF" /locus_tag="BSU_05620" /old_locus_tag="BSU05620" /label="ydgF gene" misc_feature complement(569182..569201) /Source="Nicolas_upshift_promotors" /id="U437" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.897102897102897" /psig=1 /xcortree=1890 /SigmaFactorBS="aatcacattaaaattcttttcatcaatccttttttagtaaaa aagatagaaattttAGTGTTATAATAATCATTAAaaatagattgctgactcaataaac a" /listShort="ydgF" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(569197) /Source="Nicolas_upshifts" /id="U437" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.897102897102897" /psig=1 /xcortree=1890 /SigmaFactorBS="aatcacattaaaattcttttcatcaatccttttttagtaaaa aagatagaaattttAGTGTTATAATAATCATTAAaaatagattgctgactcaataaac a" /listShort="ydgF" /GFF_Attribute="listLong" /label="upshifts" Polymorphism join(569271,569273) /Source="geneious" /ID="SNP_BsDelta6_608215_608214" /Polymorphism_Type="Insertion (tandem repeat)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=0 /Amino_Acid_Change /CDS_Position /Change="(A)5 -> (A)6" /Codon_Change /Coverage=41 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides /Variant_Nucleotides="A" /Variant_P_Value="8.2e-115" /Variant_Raw_Frequency=39 /comment="dinB_terminator_improvement" /modified_by="User" / /label="Polymorphism_Delta6" terminator 569272..569305 /created_by="User" /comment="dinB_terminator_improvement" /modified_by="User" /label="Delta6_dinB_Terminator" CDS complement(569304..569822) /gene="dinB" /locus_tag="BSU_05630" /old_locus_tag="BSU05630" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 1847907, 3110138, 12644484, 16267290, 22059487; Product type r: regulator" /codon_start=1 /transl_table=11 /product="nuclease inhibitor" /protein_id="NP_388444.1" /db_xref="EnsemblGenomes-Gn:BSU05630" /db_xref="EnsemblGenomes-Tr:CAB12370" /db_xref="GOA:Q02886" /db_xref="InterPro:IPR007837" /db_xref="InterPro:IPR034660" /db_xref="SubtiList:BG10539" /db_xref="UniProtKB/Swiss-Prot:Q02886" /translation="MSDFAFKLYEYNVWANQQIFNRLKELPKEIYHQEIQSVFPSISH VLSHVYLSDLGWIEVFSGKTLSDALALAEQLKEQTEAKEIEEMEDLFLRLSERYILFL QQKEQLNKPLQIQNPSSGIMKTTVSELLPHVVNHGTYHRGNITAMLRQAGYASAPTDY GLYLFMTKTEKA*" /label="dinB CDS" gene complement(569304..569822) /gene="dinB" /locus_tag="BSU_05630" /old_locus_tag="BSU05630" /label="dinB gene" downshifts complement(569318) /Source="Nicolas_upshifts" /id="D271" /incds=0 /nref=35 /ntot=176 /MaxReadThrough="2.77148" /MaxDrop="6.32316" /score="16.2748201" /energy="-15" /TU="NA" /idTUdmin="U438" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(569848..569867) /Source="Nicolas_upshift_promotors" /id="U438" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.839160839160839" /psig=1 /xcortree=1506 /SigmaFactorBS="tcctctaaactatatatgtcaacaaattttattttcgagcaC TCTacataagaactcatgTTCGTGTATAATGAAAGCTAtacacacgaaagggggaatt t" /listShort="dinB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(569867) /Source="Nicolas_upshifts" /id="U438" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.839160839160839" /psig=1 /xcortree=1506 /SigmaFactorBS="tcctctaaactatatatgtcaacaaattttattttcgagcaC TCTacataagaactcatgTTCGTGTATAATGAAAGCTAtacacacgaaagggggaatt t" /listShort="dinB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(569883..569886) /Source="Nicolas_upshift_promotors" /id="U438" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.839160839160839" /psig=1 /xcortree=1506 /SigmaFactorBS="tcctctaaactatatatgtcaacaaattttattttcgagcaC TCTacataagaactcatgTTCGTGTATAATGAAAGCTAtacacacgaaagggggaatt t" /listShort="dinB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 569904..569911 /Source="Nicolas_upshift_promotors" /id="U439" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig="0.97002997002997" /xcortree=2440 /SigmaFactorBS="gagtgctcgaaaataaaattTGTTGACAtatatagtttagag GAATAAACTAATTGACATTGaacataaagtttagcggggtaaactataatgaggaggg g" /listShort="ydgG, ydgH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 569926..569945 /Source="Nicolas_upshift_promotors" /id="U439" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig="0.97002997002997" /xcortree=2440 /SigmaFactorBS="gagtgctcgaaaataaaattTGTTGACAtatatagtttagag GAATAAACTAATTGACATTGaacataaagtttagcggggtaaactataatgaggaggg g" /listShort="ydgG, ydgH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 569944 /Source="Nicolas_upshifts" /id="U439" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig="0.97002997002997" /xcortree=2440 /SigmaFactorBS="gagtgctcgaaaataaaattTGTTGACAtatatagtttagag GAATAAACTAATTGACATTGaacataaagtttagcggggtaaactataatgaggaggg g" /listShort="ydgG, ydgH" /GFF_Attribute="listLong" /label="upshifts" CDS 569991..570449 /gene="ydgG" /locus_tag="BSU_05640" /old_locus_tag="BSU05640" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)" /protein_id="NP_388445.1" /db_xref="EnsemblGenomes-Gn:BSU05640" /db_xref="EnsemblGenomes-Tr:CAB12371" /db_xref="GOA:P96705" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12174" /db_xref="UniProtKB/Swiss-Prot:P96705" /translation="MNEQKLCQAINLFVEVLLEGTEFVHREINQDVFKHISREQADLL KILKVKGPTSPGSLAMYQNVHKSAISNRLKKLLEKGLVQWDDCPEKSDRRSKLINITP SGEHILEELDSAIFNALKPLIDDIDEEHLHSIIEIFTILKSKFKGGDSAE*" /label="ydgG CDS" gene 569991..570449 /gene="ydgG" /locus_tag="BSU_05640" /old_locus_tag="BSU05640" /label="ydgG gene" CDS 570446..573103 /gene="ydgH" /locus_tag="BSU_05650" /old_locus_tag="BSU05650" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15941986; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane component" /protein_id="NP_388446.1" /db_xref="EnsemblGenomes-Gn:BSU05650" /db_xref="EnsemblGenomes-Tr:CAB12372" /db_xref="GOA:P96706" /db_xref="InterPro:IPR000731" /db_xref="InterPro:IPR004869" /db_xref="SubtiList:BG12175" /db_xref="UniProtKB/Swiss-Prot:P96706" /translation="MRAIIKFKWAIAAIVLALTVVLSLFSPNLTELANQKGQAQLPAD AVSERANAILKQAGEDNNSISVVFTLDNAIKKETENQLRIIIDKIKKIDGVEEVTSPL SAEKEVKDQLMSKDKKTVLMPVTITGSDKKAEKIADEIYQIVPDDLTAYITGASLINQ DFAHSSEEGLKKTEVITVCLIIGLLLIVFRSVVTPFIPIVVVGFSYLISQSILGILVY NVDFPISTFTQTFLVAILFGIGTDYCILLLTRFREELANGHDKKEAALIAYRTGGKTL FISGFAVLIGFSALGFAKFAIFQSAVGVAVGVGILMIILYTLLPLFMVTLGEKLFWPS KKVLSHSDNKLWAFLGRHSVARPFLFIVITVVITLPFILTYDDQISFDSTAEISSDYK SIKALEAIKDGFGEGKAFPINVVVKGDKDLTTADTIPYLGNISKAIEKVDHVDSVMTI TQPTGKKIKDLYIDNQLGSVSDGLDKTVKGIADVQSGLTDIENGLNQMAGQTGSASNG GSGGSLGDAADGLGKINQQLQLVSKQISQTGNTAQTVQQLTAISGQLGQIQTGLEQAN QQLSGQQAQAGTLTESLKKLSEGVKSANEGLTKVSDGITASSDILEDMSKSPTVRDTG IFIPDQVMKDKDFKKSIDQYSFADGKGVQLSVVLDSNPYSEQAITTINQIKKAVANEV DGTPLENAQIVYGGVTSMNADLKELSTTDFSRTMVIMIIGLFIVLTILFRSMIMPIYM IASLLLTYYTSISITELIFVNGLGNAGVSWAVPFFSFVILIALGVDYSIFLLDRFKEE VHLGIEQGVVRSMSKMGSVIITAAIILAGTFAAMMPSGVNTLMQVASVIIIGLLLYGL VILPLFIPAIIATFGEGNWWPFGRKKGKE*" /label="ydgH CDS" gene 570446..573103 /gene="ydgH" /locus_tag="BSU_05650" /old_locus_tag="BSU05650" /label="ydgH gene" downshifts 573224 /Source="Nicolas_upshifts" /id="D272" /incds=0 /nref=3 /ntot=27 /MaxReadThrough="0.245049999999999" /MaxDrop="4.45167" /score="13.780898" /energy="-13.9" /TU="NA" /idTUdmin="U439" /TUdmin=22 /isTUend="TRUE" /label="downshifts" CDS complement(573249..573878) /gene="ydgI" /locus_tag="BSU_05660" /old_locus_tag="BSU05660" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 26415543; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="nitroreductase of unidentified specificity (reduces 5-(aziridin-1-yl)-2,4-dinitrobenzamide prodrug)" /protein_id="NP_388447.1" /db_xref="EnsemblGenomes-Gn:BSU05660" /db_xref="EnsemblGenomes-Tr:CAB12385" /db_xref="GOA:P96707" /db_xref="InterPro:IPR000415" /db_xref="InterPro:IPR029479" /db_xref="SubtiList:BG12176" /db_xref="UniProtKB/Swiss-Prot:P96707" /translation="MIKTNDFMEIMKGRRSIRNYDPAVKISKEEMTEILEEATTAPSS VNAQPWRFLVIDSPEGKEKLAPLASFNQTQVTTSSAVIAVFADMNNADYLEEIYSKAV ELGYMPQEVKDRQIAALTAHFEKLPAQVNRETILIDGGLVSMQLMLTARAHGYDTNPI GGYDKENIAETFGLDKERYVPVMLLSIGKAADEGYASYRLPIDTIAEWK*" /label="ydgI CDS" gene complement(573249..573878) /gene="ydgI" /locus_tag="BSU_05660" /old_locus_tag="BSU05660" /label="ydgI gene" downshifts complement(573253) /Source="Nicolas_upshifts" /id="D273" /incds=0 /nref=21 /ntot=184 /MaxReadThrough="2.66406" /MaxDrop="6.06581" /score="21.7451043" /energy="-16.6" /TU="NA" /idTUdmin="U440" /TUdmin=3 /isTUend="TRUE" /label="downshifts" CDS complement(573894..574388) /gene="ydgJ" /locus_tag="BSU_05670" /old_locus_tag="BSU05670" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)" /protein_id="NP_388448.1" /db_xref="EnsemblGenomes-Gn:BSU05670" /db_xref="EnsemblGenomes-Tr:CAB12386" /db_xref="GOA:P96708" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR001845" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12177" /db_xref="UniProtKB/Swiss-Prot:P96708" /translation="MTCQSLIYQLIVLTGKKGWVLASFCSEEAEILYQLQGVNKVIGV KFEACTGISQSRLELLTLLYHADEISQSDLQKKVNIDSAAVTRHLKQLESKGMVSRRR KPEDNRITLVRLTDQGRERIESSKKEKERFMKEMLANVSAEERRLLIDVLARMRNNIN NIEA*" /label="ydgJ CDS" gene complement(573894..574388) /gene="ydgJ" /locus_tag="BSU_05670" /old_locus_tag="BSU05670" /label="ydgJ gene" promotor_-10 complement(574380..574399) /Source="Nicolas_upshift_promotors" /id="U440" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=1967 /SigmaFactorBS="ttatgcgctgggaggttgttcaaaagtgcaaatggCTTGCAa gatgaaatcaatcgTTGTATATTAATTGACGTGTcaatcattgatatatcaattaata g" /listShort="ydgJ, ydgI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(574395) /Source="Nicolas_upshifts" /id="U440" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=1967 /SigmaFactorBS="ttatgcgctgggaggttgttcaaaagtgcaaatggCTTGCAa gatgaaatcaatcgTTGTATATTAATTGACGTGTcaatcattgatatatcaattaata g" /listShort="ydgJ, ydgI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(574415..574420) /Source="Nicolas_upshift_promotors" /id="U440" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=1967 /SigmaFactorBS="ttatgcgctgggaggttgttcaaaagtgcaaatggCTTGCAa gatgaaatcaatcgTTGTATATTAATTGACGTGTcaatcattgatatatcaattaata g" /listShort="ydgJ, ydgI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 574586..574588 /Source="Nicolas_upshift_promotors" /id="U441" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=2606 /SigmaFactorBS="ttcggaatatcactttgccggcccgtgctcaagcggCTTtca caggctgaaagtTATGATACAATATACAAATGtttcacagcttcaatccatagttgga g" /listShort="S199, ydgK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 574604..574623 /Source="Nicolas_upshift_promotors" /id="U441" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=2606 /SigmaFactorBS="ttcggaatatcactttgccggcccgtgctcaagcggCTTtca caggctgaaagtTATGATACAATATACAAATGtttcacagcttcaatccatagttgga g" /listShort="S199, ydgK" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 574610..574698 /Source="Nicolas_S_feature" /locus_tag="new_613552_613640" /HighExp="H2O2, G180, G135, Diami, Paraq, Oxctl, G150, LBGexp, LPh, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S199" upshifts 574610 /Source="Nicolas_upshifts" /id="U441" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=2606 /SigmaFactorBS="ttcggaatatcactttgccggcccgtgctcaagcggCTTtca caggctgaaagtTATGATACAATATACAAATGtttcacagcttcaatccatagttgga g" /listShort="S199, ydgK" /GFF_Attribute="listLong" /label="upshifts" CDS 574699..575907 /gene="ydgK" /locus_tag="BSU_05680" /old_locus_tag="BSU05680" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388449.1" /db_xref="EnsemblGenomes-Gn:BSU05680" /db_xref="EnsemblGenomes-Tr:CAB12387" /db_xref="GOA:P96709" /db_xref="InterPro:IPR004812" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12178" /db_xref="UniProtKB/Swiss-Prot:P96709" /translation="MLHNPTGKERLALAFLLGMLAILGPLNIDMYLPSFPEIAKDLSA SASLVQLSLTACLVGLTIGQLIVGPVSDAQGRRKPLLICIFLFALSSLFCALSPNITT LVAARFLQGFTASAGLVLSRAIVRDVFTGRELSKFFSLLMVITAVAPMVAPMTGGAIL LLPFATWHTIFHVLMIIGFLLVLLIALRLKETLPLEKRIPSSIGTSVKTMGSLLKDRS FMGYALTVGFIHGGSFAYVSGTPFVYQDIYGVSPQVFSILFGINGLAIISGSFIIGRF GGIIHEKSLLRIAVITAMIATAVLLTMTMIHGPLATLVISIFIYMITIGMVLTSTFTL AMEKQGHRAGSASALLGMLPLLLGSIVSPLVGINETTAVPMGAIMFVTAVIGSLAFFG LTKERVGQNS*" /label="ydgK CDS" gene 574699..575907 /gene="ydgK" /locus_tag="BSU_05680" /old_locus_tag="BSU05680" /label="ydgK gene" downshifts 575886 /Source="Nicolas_upshifts" /id="D274" /incds=0 /nref=23 /ntot=112 /MaxReadThrough="0.507390000000001" /MaxDrop="3.27202" /score="25.806679" /energy="-7.5" /TU="NA" /idTUdmin="U441" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(575943..576680) /gene="ydhB" /locus_tag="BSU_05690" /old_locus_tag="BSU05690" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388450.2" /db_xref="EnsemblGenomes-Gn:BSU05690" /db_xref="EnsemblGenomes-Tr:CAB12388" /db_xref="GOA:O05493" /db_xref="InterPro:IPR002781" /db_xref="SubtiList:BG12179" /db_xref="UniProtKB/Swiss-Prot:O05493" /translation="MLIILVMFLLGIILGFIGAGGAGFVIALLTLLFHIPIHTALGTS LAGMAFTSLSGAYSHYREGNIQMKIGLIVGGFAAVGSFFGAKLTSFIPADLLHYLTAG MLFLSAILILIRLFILKEKAQVNQSTLSTYTRAVILGIAAGVLSGTFGIGSAPFIQIG LMIMLNLSIRHSVGTTMLVIIPLAVGGGIGYITEGFVDYVLLVKVLVGTMCGAYVGAK FTNLMPKVVLKSAIFLTPAIAGLLLLF*" /label="ydhB CDS" gene complement(575943..576680) /gene="ydhB" /locus_tag="BSU_05690" /old_locus_tag="BSU05690" /label="ydhB gene" S_feature complement(576681..576819) /Source="Nicolas_S_feature" /locus_tag="new_615623_615761_c" /HighExp="T0.30H, T1.30H, T1.0H, T-0.40H, T2.0H, T0.0H, LBGstat, T2.30H, T-1.10H, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.108111" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S200" promotor_-10 complement(576807..576826) /Source="Nicolas_upshift_promotors" /id="U442" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.773226773226773" /psig="0.999000999001" /xcortree=1711 /SigmaFactorBS="atataacagatggtaatgggaagcaacaaactGCCTTGTCag atccctgaattTGAGGTACGATATGTTTGCTgaacgacggtcgacggactactggcaa c" /listShort="S200, ydhB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(576819) /Source="Nicolas_upshifts" /id="U442" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.773226773226773" /psig="0.999000999001" /xcortree=1711 /SigmaFactorBS="atataacagatggtaatgggaagcaacaaactGCCTTGTCag atccctgaattTGAGGTACGATATGTTTGCTgaacgacggtcgacggactactggcaa c" /listShort="S200, ydhB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(576840..576847) /Source="Nicolas_upshift_promotors" /id="U442" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.773226773226773" /psig="0.999000999001" /xcortree=1711 /SigmaFactorBS="atataacagatggtaatgggaagcaacaaactGCCTTGTCag atccctgaattTGAGGTACGATATGTTTGCTgaacgacggtcgacggactactggcaa c" /listShort="S200, ydhB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 576851..576858 /Source="Nicolas_upshift_promotors" /id="U443" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.999000999001" /xcortree=1978 /SigmaFactorBS="atcgtacctcaaattcagggatctgacaaggcagtTTGTTGC TtcccattaccatcTGTTATATGATTTTGATGAAgaaaagcccttgaatatattcaaa a" /listShort="ydhC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 576872..576891 /Source="Nicolas_upshift_promotors" /id="U443" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.999000999001" /xcortree=1978 /SigmaFactorBS="atcgtacctcaaattcagggatctgacaaggcagtTTGTTGC TtcccattaccatcTGTTATATGATTTTGATGAAgaaaagcccttgaatatattcaaa a" /listShort="ydhC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 576876 /Source="Nicolas_upshifts" /id="U443" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.999000999001" /xcortree=1978 /SigmaFactorBS="atcgtacctcaaattcagggatctgacaaggcagtTTGTTGC TtcccattaccatcTGTTATATGATTTTGATGAAgaaaagcccttgaatatattcaaa a" /listShort="ydhC" /GFF_Attribute="listLong" /label="upshifts" CDS 576929..577603 /gene="ydhC" /locus_tag="BSU_05700" /old_locus_tag="BSU05700" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (GntR family)" /protein_id="NP_388451.1" /db_xref="EnsemblGenomes-Gn:BSU05700" /db_xref="EnsemblGenomes-Tr:CAB12389" /db_xref="GOA:O05494" /db_xref="InterPro:IPR000485" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR008920" /db_xref="InterPro:IPR011711" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12180" /db_xref="UniProtKB/Swiss-Prot:O05494" /translation="MDDFKLDKPTPYYLQFYNQLKKMIFNGTFKPGERINETQLAKSF GVSRSPIREAMRLLEKDGLLKADDRNGFSITSLTAKDVDEIYKIRIPLEQLAVELVID EADEEELTILEKQLEETEKAIHNGTEDTEIIRLNQKFHELLVDFSHNRHLKNLLEHVN DLIHFCRILNYTGDHRAETILREHRRIFEEVKKKNKEAAKQHVLAHFNHDCEHLKHVL EEGKEN*" /label="ydhC CDS" gene 576929..577603 /gene="ydhC" /locus_tag="BSU_05700" /old_locus_tag="BSU05700" /label="ydhC gene" promotor_-35 577662..577667 /Source="Nicolas_upshift_promotors" /id="U444" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1131 /SigmaFactorBS="agcagaacccttggtatttttttatgtattcacCACATAtct aagaggccccgtTAATAAGATTTTATGATGGtttgactaacgaataatgggggttaaa t" /listShort="ydhD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 577683..577701 /Source="Nicolas_upshift_promotors" /id="U444" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1131 /SigmaFactorBS="agcagaacccttggtatttttttatgtattcacCACATAtct aagaggccccgtTAATAAGATTTTATGATGGtttgactaacgaataatgggggttaaa t" /listShort="ydhD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 577689 /Source="Nicolas_upshifts" /id="U444" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1131 /SigmaFactorBS="agcagaacccttggtatttttttatgtattcacCACATAtct aagaggccccgtTAATAAGATTTTATGATGGtttgactaacgaataatgggggttaaa t" /listShort="ydhD" /GFF_Attribute="listLong" /label="upshifts" CDS 577730..578992 /gene="spoL" /locus_tag="BSU_05710" /old_locus_tag="BSU05710" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11011148, 12177332; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore cortex lytic enzyme" /protein_id="NP_388452.2" /db_xref="EnsemblGenomes-Gn:BSU05710" /db_xref="EnsemblGenomes-Tr:CAB12390" /db_xref="GOA:O05495" /db_xref="InterPro:IPR001223" /db_xref="InterPro:IPR011583" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="PDB:3CZ8" /db_xref="SubtiList:BG12181" /db_xref="UniProtKB/Swiss-Prot:O05495" /translation="MFIHIVGPGDSLFSIGRRYGASVDQIRGVNGLDETNIVPGQALL IPLYVYTVQPRDTLTAIAAKAFVPLERLRAANPGISPNALQAGAKITIPSISNYIAGT LSFYVLRNPDLDRELINDYAPYSSSISIFEYHIAPNGDIANQLNDAAAIETTWQRRVT PLATITNLTSGGFSTEIVHQVLNNPTARTNLVNNIYDLVSTRGYGGVTIDFEQVSAAD RDLFTGFLRQLRDRLQAGGYVLTIAVPAKTSDNIPWLRGYDYGGIGAVVNYMFIMAYD WHHAGSEPGPVAPITEIRRTIEFTIAQVPSRKIIIGVPLYGYDWIIPYQPGTVASAIS NQNAIERAMRYQAPIQYSAEYQSPFFRYSDQQGRTHEVWFEDVRSMSRKMQIVREYRL QAIGAWQLTLGFTPGPWLLRKFFTIRKV*" /label="spoL CDS" gene 577730..578992 /gene="spoL" /locus_tag="BSU_05710" /old_locus_tag="BSU05710" /label="spoL gene" downshifts 578966 /Source="Nicolas_upshifts" /id="D275" /incds=0 /nref=33 /ntot=81 /MaxReadThrough="2.3134" /MaxDrop="5.20337" /score="15.7593331" /energy="-7.1" /TU="NA" /idTUdmin="U444" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 579064..579071 /Source="Nicolas_upshift_promotors" /id="U445" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.612387612387612" /psig="0.999000999001" /xcortree=1616 /SigmaFactorBS="taagtccagagcagcagaatagttcattcatttgtACCTTGC AtgggttgtgttccCATTTTACGATTAGTAGTAGtctgatcaaacaaagagtcagaat a" /listShort="ydhE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 579085..579104 /Source="Nicolas_upshift_promotors" /id="U445" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.612387612387612" /psig="0.999000999001" /xcortree=1616 /SigmaFactorBS="taagtccagagcagcagaatagttcattcatttgtACCTTGC AtgggttgtgttccCATTTTACGATTAGTAGTAGtctgatcaaacaaagagtcagaat a" /listShort="ydhE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 579089 /Source="Nicolas_upshifts" /id="U445" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.612387612387612" /psig="0.999000999001" /xcortree=1616 /SigmaFactorBS="taagtccagagcagcagaatagttcattcatttgtACCTTGC AtgggttgtgttccCATTTTACGATTAGTAGTAGtctgatcaaacaaagagtcagaat a" /listShort="ydhE" /GFF_Attribute="listLong" /label="upshifts" CDS 579153..580340 /gene="ydhE" /locus_tag="BSU_05720" /old_locus_tag="BSU05720" /function="18.1: Enzymes of unknown specificity" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20639339; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_388453.2" /db_xref="EnsemblGenomes-Gn:BSU05720" /db_xref="EnsemblGenomes-Tr:CAB12391" /db_xref="GOA:O05496" /db_xref="InterPro:IPR002213" /db_xref="InterPro:IPR006326" /db_xref="SubtiList:BG12182" /db_xref="UniProtKB/Swiss-Prot:O05496" /translation="MKTVLILNFPAEGHVNPTLGITKAFSDKGYDVHYISTEKYKKRL EAAGATVHLHRDLLRTTPIHVGSPNGILDFVKIHIKTSLDILQIVKDLSKSIQFDFVY YDKFGAGELVRDYLDIPGVSSSASFLFGEEHLKILPLHPESGAPLELDQECEDLLAKM KETYGVAPKNLVQFMNNKGELNVVYTSRYFQPESDRFGDECLFIGPSFPKRAEKTDFP IEQLKDEKVIYISMGTVLDHTEDFFNLCIDAFSGFNGKVVIAAGEKADLTKLKQAPEN FIIAPYVPQLEVLEQSDVFITHGGMNSVNEGIHFSVPLVVMPHDKDQPMVAQRLSELH AGYVISKDEVNAQILKQAVDEVLRNDQYTAGIKKINQSFKECMDMEEVMERIDELIRQ KNK*" /label="ydhE CDS" gene 579153..580340 /gene="ydhE" /locus_tag="BSU_05720" /old_locus_tag="BSU05720" /label="ydhE gene" downshifts 580352 /Source="Nicolas_upshifts" /id="D276" /incds=0 /nref=17 /ntot=224 /MaxReadThrough="1.77672" /MaxDrop="5.25325" /score="-6.36206618" /energy="-12.6" /TU="NA" /idTUdmin="U445" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(580379..581089) /gene="ydhF" /locus_tag="BSU_05730" /old_locus_tag="BSU05730" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10913081, 11557812; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative phosphate-starvation lipoprotein" /protein_id="NP_388454.1" /db_xref="EnsemblGenomes-Gn:BSU05730" /db_xref="EnsemblGenomes-Tr:CAB12392" /db_xref="InterPro:IPR029050" /db_xref="InterPro:IPR029051" /db_xref="SubtiList:BG12183" /db_xref="UniProtKB/Swiss-Prot:O05497" /translation="MRRILSILVFAIMLAGCSSNASTEKQHAGGEKTVKAEPQSTSSQ KDSTDDYQPNSQVTDDRTLHKVGQTFSDDKGKAVLKDIKQVNKTYKIGDVELTVKEMK LIHLRPDYSMIDYFHELTHDEEFDFVKVFVDIKNTSTKKVNVAPIALMKTNTGETFDW NKDIYLEELNGELEGGAEKSGNLGFIVNASSGHAHDKAADAEKKTKEIKWIEITTSDV FDHNHKKISDAQKIKIKF*" /label="ydhF CDS" gene complement(580379..581089) /gene="ydhF" /locus_tag="BSU_05730" /old_locus_tag="BSU05730" /label="ydhF gene" downshifts complement(580405) /Source="Nicolas_upshifts" /id="D277" /incds=0 /nref=11 /ntot=36 /MaxReadThrough="4.05808" /MaxDrop="4.7318" /score="13.7192471" /energy="-12.6" /TU="NA" /idTUdmin="U446" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(581155..582543) /gene="phoB" /locus_tag="BSU_05740" /old_locus_tag="BSU05740" /EC_number="3.1.3.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9335276, 10913081, 16030210, 16491025, 26382712, 27226549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9335276, 10913081, 16030210, 16491025, 26382712, 27226549; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="alkaline phosphatase III (promiscuous, heptaprenylglyceryl phosphate is a substrate)" /protein_id="NP_388455.2" /db_xref="EnsemblGenomes-Gn:BSU05740" /db_xref="EnsemblGenomes-Tr:CAB12393" /db_xref="GOA:P19405" /db_xref="InterPro:IPR001952" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="InterPro:IPR018299" /db_xref="SubtiList:BG10697" /db_xref="UniProtKB/Swiss-Prot:P19405" /translation="MKKFPKKLLPIAVLSSIAFSSLASGSVPEASAQEKKKGNQDEIK NVIVLIGDGMGVSYTSAYRYLKDNKKTKVVEPTAFDQYLVGQQTTYPDDPEQNVTDSA AAATAMSAGIKTYNNAIAVDNDGSEAKTVLEAAKEKGKATGLVATSEITHATPASFGS HDHSRKNMNSIADDYFDEMVNGKHKIDVLLGGGKSNFDRKDRNLIKEFKKAGYSYVDD RKDMLKNKDSQVLGLFADGGLPKKIDRTKDIPSLKDMTNTAIKKLNKDKDGFFLMVEG SQIDWAGHDNDIVGAMSEMEDFEQAYKAAIDFAKKDKHTLVVATADHSTGGYSIGADG IYNWFSEPIKAAKRTPDFMAEKIADGADVEKTLKTYIDQKKLALTKAEIQSVEEAAKS KEVLDIDNAIENIFNKRSHTGWTTGGHTGEDVPVYAYGPSSETFAGQIDNTEIAKNVF KALQYNIKINDK*" /label="phoB CDS" gene complement(581155..582543) /gene="phoB" /locus_tag="BSU_05740" /old_locus_tag="BSU05740" /label="phoB gene" promotor_-10 complement(582600..582617) /Source="Nicolas_upshift_promotors" /id="U446" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.982017982017982" /psig="0.011988011988012" /xcortree=9 /SigmaFactorBS="ggtgccagttcattattcttgtaaatccaaTCTTTAAAatcg atTAATACTAGCTTAACAGTttaaaaatataattgggttgtcattgagattcatctat a" /listShort="phoB, ydhF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(582601) /Source="Nicolas_upshifts" /id="U446" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.982017982017982" /psig="0.011988011988012" /xcortree=9 /SigmaFactorBS="ggtgccagttcattattcttgtaaatccaaTCTTTAAAatcg atTAATACTAGCTTAACAGTttaaaaatataattgggttgtcattgagattcatctat a" /listShort="phoB, ydhF" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(582603..582671) /Source="Nicolas_S_feature" /locus_tag="new_621545_621613_c" /HighExp="S6, S4, S5, S3, S7, LoTm, S8, T5.0H, B36, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S201" promotor_-35 complement(582624..582631) /Source="Nicolas_upshift_promotors" /id="U446" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.982017982017982" /psig="0.011988011988012" /xcortree=9 /SigmaFactorBS="ggtgccagttcattattcttgtaaatccaaTCTTTAAAatcg atTAATACTAGCTTAACAGTttaaaaatataattgggttgtcattgagattcatctat a" /listShort="phoB, ydhF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(582661..582679) /Source="Nicolas_upshift_promotors" /id="U447" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1157 /SigmaFactorBS="tattcctccaatttatttctttagtactatcgctctttcCTT CTAaaacttctcataaaaGAATAACCATTATTTAAGGgtgccagttcattattcttgt a" /listShort="S201, phoB, ydhF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(582679) /Source="Nicolas_upshifts" /id="U447" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1157 /SigmaFactorBS="tattcctccaatttatttctttagtactatcgctctttcCTT CTAaaacttctcataaaaGAATAACCATTATTTAAGGgtgccagttcattattcttgt a" /listShort="S201, phoB, ydhF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(582695..582700) /Source="Nicolas_upshift_promotors" /id="U447" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1157 /SigmaFactorBS="tattcctccaatttatttctttagtactatcgctctttcCTT CTAaaacttctcataaaaGAATAACCATTATTTAAGGgtgccagttcattattcttgt a" /listShort="S201, phoB, ydhF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 582748..582755 /Source="Nicolas_upshift_promotors" /id="U448" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.642357642357642" /psig="0.997002997002997" /xcortree=1887 /SigmaFactorBS="tagtactaaagaaataaattggaggaatagatactggCCGTG GATaggcggactgaaaTCTGCTATAGTCGCATAGAAgcaacccgcttacatcttgaac a" /listShort="S202, ydhG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 582769..582788 /Source="Nicolas_upshift_promotors" /id="U448" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.642357642357642" /psig="0.997002997002997" /xcortree=1887 /SigmaFactorBS="tagtactaaagaaataaattggaggaatagatactggCCGTG GATaggcggactgaaaTCTGCTATAGTCGCATAGAAgcaacccgcttacatcttgaac a" /listShort="S202, ydhG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 582771..582904 /Source="Nicolas_S_feature" /locus_tag="new_621713_621846" /HighExp="Diami, dia15, H2O2, Paraq, Oxctl, HPh, G180, G135, LPh, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S202" upshifts 582771 /Source="Nicolas_upshifts" /id="U448" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.642357642357642" /psig="0.997002997002997" /xcortree=1887 /SigmaFactorBS="tagtactaaagaaataaattggaggaatagatactggCCGTG GATaggcggactgaaaTCTGCTATAGTCGCATAGAAgcaacccgcttacatcttgaac a" /listShort="S202, ydhG" /GFF_Attribute="listLong" /label="upshifts" CDS 582905..583276 /gene="fra" /locus_tag="BSU_05750" /old_locus_tag="BSU05750" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:20087498, 21744456, 25826316" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20087498, 21744456, 25826316; Product type f: factor" /codon_start=1 /transl_table=11 /product="frataxin; iron/sulfur chaperone" /protein_id="NP_388456.1" /db_xref="EnsemblGenomes-Gn:BSU05750" /db_xref="EnsemblGenomes-Tr:CAB12394" /db_xref="GOA:Q797E6" /db_xref="InterPro:IPR014922" /db_xref="PDB:2OC6" /db_xref="SubtiList:BG12184" /db_xref="UniProtKB/Swiss-Prot:Q797E6" /translation="MDVFSEYLAGIADPFHRERTEEVLTWIKNKYPNLHTEIKWNQPM FTDHGTFIIGFSVSKKHLAVAPEKVTIAHVEDDIVKAGYDYTEQLIRIPWNGPVDYTL LEKMIEFNILDKADCSTFWRK*" /label="fra CDS" gene 582905..583276 /gene="fra" /locus_tag="BSU_05750" /old_locus_tag="BSU05750" /label="fra gene" downshifts 583255 /Source="Nicolas_upshifts" /id="D278" /incds=0 /nref=9 /ntot=150 /MaxReadThrough="2.88587" /MaxDrop="3.59127" /score="28.8500849" /energy="-8.1" /TU="NA" /idTUdmin="U448" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(583350) /Source="Nicolas_upshifts" /id="D279" /incds=0 /nref=9 /ntot=187 /MaxReadThrough="1.63268" /MaxDrop="2.98181" /score="0.51805655" /energy="-13" /TU="NA" /idTUdmin="U450" /TUdmin=2 /isTUend="TRUE" /label="downshifts" CDS complement(583351..583848) /gene="ydhH" /locus_tag="BSU_05760" /old_locus_tag="BSU05760" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388457.1" /db_xref="EnsemblGenomes-Gn:BSU05760" /db_xref="EnsemblGenomes-Tr:CAB12395" /db_xref="GOA:O05500" /db_xref="InterPro:IPR032545" /db_xref="SubtiList:BG12185" /db_xref="UniProtKB/Swiss-Prot:O05500" /translation="MSSHYKYPLIFTAFLLIAFCLIFFSYHLIHHVRLEYPNWQGESK DQNWEAVFTKNEDAPNEYSGKLYWIGDTIEIDNTYLESLIVKKDDEVLLSSDTEIPMH DYAGGTFSDGSAKEKSVSFLERLDEHELEGHDITIEVKWKQGNHYSASQLTLNEKTLF DEKQQ*" /label="ydhH CDS" gene complement(583351..583848) /gene="ydhH" /locus_tag="BSU_05760" /old_locus_tag="BSU05760" /label="ydhH gene" CDS complement(583866..584348) /gene="ydhI" /locus_tag="BSU_05770" /old_locus_tag="BSU05770" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_388458.1" /db_xref="EnsemblGenomes-Gn:BSU05770" /db_xref="EnsemblGenomes-Tr:CAB12396" /db_xref="GOA:O05501" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG12186" /db_xref="UniProtKB/Swiss-Prot:O05501" /translation="MMIIIPNNEIAKHMLTDFFAKHWGTPEMAISSGIFRCDELDGFA AVNESGEIIGCITYTIDGKDCEIISLDSMIENKGIGTALLQQVEEKAKHAHCQRIKLI TTNDNVNAIAFYQKRGYQFAAVFPNAVEKARRLKPEIPEVAENGILIRDEILFSKVID *" /label="ydhI CDS" gene complement(583866..584348) /gene="ydhI" /locus_tag="BSU_05770" /old_locus_tag="BSU05770" /label="ydhI gene" promotor_-35 584021..584028 /Source="Nicolas_upshift_promotors" /id="U449" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.767232767232767" /psig=1 /xcortree=2430 /SigmaFactorBS="gaattgatagcctctcttttgataaaacgctatcgCATTTAC AttatcattcgttgTGATAAGCTTTATTCGTTGAcaatgtgcatgtttagccttctct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 584042..584061 /Source="Nicolas_upshift_promotors" /id="U449" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.767232767232767" /psig=1 /xcortree=2430 /SigmaFactorBS="gaattgatagcctctcttttgataaaacgctatcgCATTTAC AttatcattcgttgTGATAAGCTTTATTCGTTGAcaatgtgcatgtttagccttctct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 584046 /Source="Nicolas_upshifts" /id="U449" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.767232767232767" /psig=1 /xcortree=2430 /SigmaFactorBS="gaattgatagcctctcttttgataaaacgctatcgCATTTAC AttatcattcgttgTGATAAGCTTTATTCGTTGAcaatgtgcatgtttagccttctct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(584377..584396) /Source="Nicolas_upshift_promotors" /id="U450" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.619380619380619" /psig="0.994005994005994" /xcortree=2264 /SigmaFactorBS="atatcgctgatttccatgccgtcacctcaacatCTATttttt ttgttatatATTGTTTATATTGATAGTACatatgcaatctttcaatagaggagtgtta t" /listShort="ydhI, ydhH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(584387) /Source="Nicolas_upshifts" /id="U450" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.619380619380619" /psig="0.994005994005994" /xcortree=2264 /SigmaFactorBS="atatcgctgatttccatgccgtcacctcaacatCTATttttt ttgttatatATTGTTTATATTGATAGTACatatgcaatctttcaatagaggagtgtta t" /listShort="ydhI, ydhH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(584411..584414) /Source="Nicolas_upshift_promotors" /id="U450" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.619380619380619" /psig="0.994005994005994" /xcortree=2264 /SigmaFactorBS="atatcgctgatttccatgccgtcacctcaacatCTATttttt ttgttatatATTGTTTATATTGATAGTACatatgcaatctttcaatagaggagtgtta t" /listShort="ydhI, ydhH" /GFF_Attribute="listLong" /label="promotor_-35" CDS 584431..585408 /gene="ydhJ" /locus_tag="BSU_05780" /old_locus_tag="BSU05780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent phosphohydrolase" /protein_id="NP_388459.1" /db_xref="EnsemblGenomes-Gn:BSU05780" /db_xref="EnsemblGenomes-Tr:CAB12397" /db_xref="GOA:O05502" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR006674" /db_xref="SubtiList:BG12187" /db_xref="UniProtKB/Swiss-Prot:O05502" /translation="MEISDIIYGQHHIDGVLEELIKSAPVQRLKGIYQGGASFLVNRK WNVTRYEHSIGVMLLIKKLGGTIEEQIAGLLHDVSHTAFSHVVDVVFENQAEDYHENI FQQVIVHSEIPDILQKHGYHTEELLSDDSRWTLLEQPAPELCADRTDYTLRDMYRYGH INLHEAQTFLDHLIVRNGRMFPDSIEAAEWFVSVYYKEVIDFFLNPVNVYGYEYLARA LKAALRHDVISAEDLLKTDQEVLNILRASKNEEVLSLLTSIHPGIQVIEDDIQYDFHQ KKKMRLIDPSIFLDDKWIKSSGVSEKVRKMGEAAYQKAKKGVYIKILKQ*" /label="ydhJ CDS" gene 584431..585408 /gene="ydhJ" /locus_tag="BSU_05780" /old_locus_tag="BSU05780" /label="ydhJ gene" downshifts 585388 /Source="Nicolas_upshifts" /id="D280" /incds=0 /nref=2 /ntot=92 /MaxReadThrough="2.31799" /MaxDrop="3.19063" /score="28.8500849" /energy="-8.1" /TU="NA" /idTUdmin="U451" /TUdmin="-770" /isTUend="FALSE" /label="downshifts" promotor_-35 585435..585441 /Source="Nicolas_upshift_promotors" /id="U451" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=176 /SigmaFactorBS="agtaattgccgcctgacagcggctttttttaTGTTTGGcttt gcaaacaaagGGGAATAGGACAAACTGCGggaacgctttatgagaatatcagcgtatt t" /listShort="ydhK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 585456..585474 /Source="Nicolas_upshift_promotors" /id="U451" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=176 /SigmaFactorBS="agtaattgccgcctgacagcggctttttttaTGTTTGGcttt gcaaacaaagGGGAATAGGACAAACTGCGggaacgctttatgagaatatcagcgtatt t" /listShort="ydhK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 585464 /Source="Nicolas_upshifts" /id="U451" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=176 /SigmaFactorBS="agtaattgccgcctgacagcggctttttttaTGTTTGGcttt gcaaacaaagGGGAATAGGACAAACTGCGggaacgctttatgagaatatcagcgtatt t" /listShort="ydhK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 585500..585507 /Source="Nicolas_upshift_promotors" /id="U452" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.434565434565435" /psig="0.98001998001998" /xcortree=1765 /SigmaFactorBS="ataggacaaactgcgggaacgctttatgagaatatcagcgTA TTTACAtaccgttcgggggTATAGTATTATCGAGAGGGCatgttttcattgtctgcgg g" /listShort="ydhK" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 585520 /Source="Nicolas_upshifts" /id="U452" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.434565434565435" /psig="0.98001998001998" /xcortree=1765 /SigmaFactorBS="ataggacaaactgcgggaacgctttatgagaatatcagcgTA TTTACAtaccgttcgggggTATAGTATTATCGAGAGGGCatgttttcattgtctgcgg g" /listShort="ydhK" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 585521..585540 /Source="Nicolas_upshift_promotors" /id="U452" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.434565434565435" /psig="0.98001998001998" /xcortree=1765 /SigmaFactorBS="ataggacaaactgcgggaacgctttatgagaatatcagcgTA TTTACAtaccgttcgggggTATAGTATTATCGAGAGGGCatgttttcattgtctgcgg g" /listShort="ydhK" /GFF_Attribute="listLong" /label="promotor_-10" CDS 585550..586167 /gene="ydhK" /locus_tag="BSU_05790" /old_locus_tag="BSU05790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388460.1" /db_xref="EnsemblGenomes-Gn:BSU05790" /db_xref="EnsemblGenomes-Tr:CAB12398" /db_xref="InterPro:IPR011438" /db_xref="PDB:2KY9" /db_xref="PDB:4FIB" /db_xref="PDB:4MDW" /db_xref="SubtiList:BG12188" /db_xref="UniProtKB/Swiss-Prot:O05503" /translation="MSAGKSYRKKMKQRRMNMKISKYALGILMLSLVFVLSACGNNNS TKESTHDNHSDSSTHEEMDHSGSADVPEGLQESKNPKYKVGSQVIINTSHMKGMKGAE ATVTGAYDTTAYVVSYTPTNGGQRVDHHKWVIQEEIKDAGDKTLQPGDQVILEASHMK GMKGATAEIDSAEKTTVYMVDYTSTTSGEKVKNHKWVTEDELSAK*" /label="ydhK CDS" gene 585550..586167 /gene="ydhK" /locus_tag="BSU_05790" /old_locus_tag="BSU05790" /label="ydhK gene" downshifts 586154 /Source="Nicolas_upshifts" /id="D281" /incds=0 /nref=62 /ntot=212 /MaxReadThrough="1.07295" /MaxDrop="7.27889" /score="30.3859931" /energy="-11.4" /TU="U452" /idTUdmin="U451" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(586183..587349) /gene="pbuE" /locus_tag="BSU_05800" /old_locus_tag="BSU05800" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12923093, 15849754, 16850406, 17935948, 25573585" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12923093, 15849754, 16850406, 17935948, 25573585; Product type t : transporter" /codon_start=1 /transl_table=11 /product="hypoxanthine efflux transporter" /protein_id="NP_388461.2" /db_xref="EnsemblGenomes-Gn:BSU05800" /db_xref="EnsemblGenomes-Tr:CAB12399" /db_xref="GOA:Q797E3" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12189" /db_xref="UniProtKB/Swiss-Prot:Q797E3" /translation="MNFKVFLLAASTIAVGLVELIVGGILPQIANDLDISIVSAGQLI SVFALGYAVSGPLLLALTAKIERKRLYLIALFVFFLSNLVAYFSPNFATLMVSRVLAA MSTGLIVVLSLTIAPKIVAPEYRARAIGIIFMGFSSAIALGVPLGILISDSFGWRILF LGIGLLALISMLIISIFFERIPAEKMIPFREQLKTIGNLKIASSHLVTMFTLAGHYTL YAYFAPFLEETLHLSSFWVSICYFLFGISAVCGGPFGGALSDRLGSFKSILLVTGSFA IIMFLLPLSTSSMIFFLPVMVIWGLLSWSLAPAQQSYLIEIAPDSSDIQQSFNTSALQ VGIALGSAIGGVVLDQTGTVVSTAWCGGSIVIIAVLFAFISLTRPVQTAKKSSL*" /label="pbuE CDS" gene complement(586183..587349) /gene="pbuE" /locus_tag="BSU_05800" /old_locus_tag="BSU05800" /label="pbuE gene" downshifts complement(586212) /Source="Nicolas_upshifts" /id="D282" /incds=0 /nref=40 /ntot=58 /MaxReadThrough="2.22188" /MaxDrop="4.89202" /score="36.362851" /energy="-12.4" /TU="NA" /idTUdmin="U453" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_RNA complement(587404..587504) /gene="aswA" /locus_tag="BSU_misc_RNA_8" /product="adenine riboswitch" /experiment="publication(s) with functional evidences, PMID:14718920, 16201765, 19603494, 20022916, 21283784, 23087247, 25573585" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14718920, 16201765, 19603494, 20022916, 21283784, 23087247, 25573585; Product type n: RNA" /label="aswA RNA" gene complement(587404..587504) /gene="aswA" /locus_tag="BSU_misc_RNA_8" /label="aswA gene" downshifts complement(587445) /Source="Nicolas_upshifts" /id="D283" /incds=0 /nref=38 /ntot=127 /MaxReadThrough="5.85661" /MaxDrop="6.06248" /score="33.0784595" /energy="-19.4" /TU="U453" /idTUdmin="U453" /TUdmin="-1233" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(587514..587533) /Source="Nicolas_upshift_promotors" /id="U453" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=2453 /SigmaFactorBS="tatttttttccggttcaccgttttataaatttttcTATGGaa gattcattcataaTGTGGTACACTCATCAACGGaaacgaatcaattaaatagctatta t" /listShort="NA, pbuE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(587528) /Source="Nicolas_upshifts" /id="U453" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=2453 /SigmaFactorBS="tatttttttccggttcaccgttttataaatttttcTATGGaa gattcattcataaTGTGGTACACTCATCAACGGaaacgaatcaattaaatagctatta t" /listShort="NA, pbuE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(587549..587553) /Source="Nicolas_upshift_promotors" /id="U453" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=2453 /SigmaFactorBS="tatttttttccggttcaccgttttataaatttttcTATGGaa gattcattcataaTGTGGTACACTCATCAACGGaaacgaatcaattaaatagctatta t" /listShort="NA, pbuE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 587612..587619 /Source="Nicolas_upshift_promotors" /id="U454" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85914085914086" /psig="0.999000999001" /xcortree=1575 /SigmaFactorBS="aaaaaaatatgattatatttattttataaaagTATAGACAtt taaaattaaatGACTATAATAATCAATGTAAgcgttttaataacaggggggatagcag t" /listShort="gmuB, gmuA, gmuC, gmuD, S203, gmuR, gmuE, gmuF, gmuG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 587633..587652 /Source="Nicolas_upshift_promotors" /id="U454" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85914085914086" /psig="0.999000999001" /xcortree=1575 /SigmaFactorBS="aaaaaaatatgattatatttattttataaaagTATAGACAtt taaaattaaatGACTATAATAATCAATGTAAgcgttttaataacaggggggatagcag t" /listShort="gmuB, gmuA, gmuC, gmuD, S203, gmuR, gmuE, gmuF, gmuG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 587640 /Source="Nicolas_upshifts" /id="U454" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85914085914086" /psig="0.999000999001" /xcortree=1575 /SigmaFactorBS="aaaaaaatatgattatatttattttataaaagTATAGACAtt taaaattaaatGACTATAATAATCAATGTAAgcgttttaataacaggggggatagcag t" /listShort="gmuB, gmuA, gmuC, gmuD, S203, gmuR, gmuE, gmuF, gmuG" /GFF_Attribute="listLong" /label="upshifts" CDS 587680..587991 /gene="gmuB" /locus_tag="BSU_05810" /old_locus_tag="BSU05810" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 18177310; Product type t : transporter" /codon_start=1 /transl_table=11 /product="oligo-alpha-mannoside phosphotransferase system enzyme IIB" /protein_id="NP_388462.1" /db_xref="EnsemblGenomes-Gn:BSU05810" /db_xref="EnsemblGenomes-Tr:CAB12400" /db_xref="GOA:O05505" /db_xref="InterPro:IPR003501" /db_xref="InterPro:IPR013012" /db_xref="InterPro:IPR036095" /db_xref="SubtiList:BG12190" /db_xref="UniProtKB/Swiss-Prot:O05505" /translation="MKKILLACSSGMSTSLLVTKMKEYAQSIGEEAEIWAVGQDKAKE DMRKADAVLIGPQMSFLKSELQKEADQYNIQVEVIDMMAYGMADGKKAYEQALSLMVN Q*" /label="gmuB CDS" gene 587680..587991 /gene="gmuB" /locus_tag="BSU_05810" /old_locus_tag="BSU05810" /label="gmuB gene" CDS 587991..588323 /gene="gmuA" /locus_tag="BSU_05820" /old_locus_tag="BSU05820" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type t: transporter" /codon_start=1 /transl_table=11 /product="oligo-alpha-mannoside phosphotransferase system enzyme IIA" /protein_id="NP_388463.2" /db_xref="EnsemblGenomes-Gn:BSU05820" /db_xref="EnsemblGenomes-Tr:CAB12401" /db_xref="GOA:O05506" /db_xref="InterPro:IPR003188" /db_xref="InterPro:IPR036542" /db_xref="SubtiList:BG12191" /db_xref="UniProtKB/Swiss-Prot:O05506" /translation="MEQMKITNLTDEQISFQLILHSGNARSCIIQSLRAYKEGKKDEA DALIAKAEQDLSAAHDIHFQMIQKESGGEATAFSLLLMHAEDHLMSTLSMKELVKEML DLFKTKNI*" /label="gmuA CDS" gene 587991..588323 /gene="gmuA" /locus_tag="BSU_05820" /old_locus_tag="BSU05820" /label="gmuA gene" CDS 588342..589670 /gene="gmuC" /locus_tag="BSU_05830" /old_locus_tag="BSU05830" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16850406, 18177310; Product type t: transporter" /codon_start=1 /transl_table=11 /product="oligo-alpha-mannoside phosphotransferase system enzyme IIC" /protein_id="NP_388464.1" /db_xref="EnsemblGenomes-Gn:BSU05830" /db_xref="EnsemblGenomes-Tr:CAB12402" /db_xref="GOA:O05507" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR004501" /db_xref="InterPro:IPR004796" /db_xref="SubtiList:BG12192" /db_xref="UniProtKB/Swiss-Prot:O05507" /translation="MFEKISQFLVPIAGRLNNNRYLQVLRDAFMLAFPLTIFGSIFVV LTNLPFLNKIMNASMLTSFQSHFGIASTATMGIMSVFVVFGIGYYLSKSYQVEAVFGG AIALVSFLLLTPFIIQPETGDAITGVIPVDRLGAKGMFLGMITAFLSGEIYRRIVQKN LTIKMPAGVPPAVAKSFAALIPAFITLTVFLLINVMVTLFFKTNMHDVIYHAIQAPLV GLGSGIIPTLIAVFFIQILWFFGLHGQIIINSVMDPIWNTLQVENLSAYTAGKEIPHI ISKPFMEIYTVGMGGTGMTLAIVFTILIFMKSRQMKQVSKLGLAPGIFNVNEPIIFGL PIVMNPIIIVPWVLAPMVVTLVTYLAMSAGLVPPPTGVTVPWTVPLFINGIMATNSIM GGVMQLINLLIVFVIWFPFLKAMDKLNLAKEKEQAVQETAAQQNDNSIKM*" /label="gmuC CDS" gene 588342..589670 /gene="gmuC" /locus_tag="BSU_05830" /old_locus_tag="BSU05830" /label="gmuC gene" CDS 589688..591085 /gene="gmuD" /locus_tag="BSU_05840" /old_locus_tag="BSU05840" /EC_number="3.2.1.86" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14652714, 15139916, 18177310" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14652714, 15139916, 18177310; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="mannoside-phospho-beta-d-glucosidase" /protein_id="NP_388465.1" /db_xref="EnsemblGenomes-Gn:BSU05840" /db_xref="EnsemblGenomes-Tr:CAB12403" /db_xref="GOA:O05508" /db_xref="InterPro:IPR001360" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR018120" /db_xref="SubtiList:BG12193" /db_xref="UniProtKB/Swiss-Prot:O05508" /translation="MAHTEQYRFPKDFWWGSSASATQMEGAADRDGKGQNIWDYWFEK EPHRFFDHVGPADTSQFYDNYKEDIRLMKELGHNSFRMSISWSRLIPNGTGEINDKAA DFYNNVIDELIANGIEPFVNLFHFDMPMALQKIGGWVNRETVDAYENYARTCFRLFGG RVKKWFTHNEPIVPVEGGYLYDFHYPNKVDFKEAVQVGFHTMLSSARAIQAYREMKQD GKIGIILNLTPSYPRSSHPADVKAGEIADAFFNRSFLDPSVKGEFPKELVDILKHEGF MPDYNAEDLDIIKKNTVDLLGVNYYQPRRVKAKEHLPNPDAPFLPDRYFDPYVMPGRK MNPHRGWEIYEKGVYDILINLKENYGNIECFISENGMGVEGEERFRDEQGIIQDDYRI EFIKEHLKWIHRAIQEGSNVKGYHLWTFMDNWSWTNAYKNRYGFVSVNLEKDGERTVK KSGKWFKEVAEHSGF*" /label="gmuD CDS" gene 589688..591085 /gene="gmuD" /locus_tag="BSU_05840" /old_locus_tag="BSU05840" /label="gmuD gene" S_feature 591086..591172 /Source="Nicolas_S_feature" /locus_tag="new_630028_630114" /HighExp="G150, T0.30H, T1.0H, M40t90, T1.30H, Mt0, M0t90, Lbexp, dia0, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S203" promotor_-35 591150..591157 /Source="Nicolas_upshift_promotors" /id="U455" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74025974025974" /psig="0.997002997002997" /xcortree=640 /SigmaFactorBS="aatcatcataacgaatagagatgacgaaaatccgcaACATTG ATgaaatagggaaaaGAACTTATGATATCCGTAAAagcttatgtgatatcaaacagct g" /listShort="gmuR, gmuE, gmuF, gmuG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 591171..591190 /Source="Nicolas_upshift_promotors" /id="U455" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74025974025974" /psig="0.997002997002997" /xcortree=640 /SigmaFactorBS="aatcatcataacgaatagagatgacgaaaatccgcaACATTG ATgaaatagggaaaaGAACTTATGATATCCGTAAAagcttatgtgatatcaaacagct g" /listShort="gmuR, gmuE, gmuF, gmuG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 591174 /Source="Nicolas_upshifts" /id="U455" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74025974025974" /psig="0.997002997002997" /xcortree=640 /SigmaFactorBS="aatcatcataacgaatagagatgacgaaaatccgcaACATTG ATgaaatagggaaaaGAACTTATGATATCCGTAAAagcttatgtgatatcaaacagct g" /listShort="gmuR, gmuE, gmuF, gmuG" /GFF_Attribute="listLong" /label="upshifts" CDS 591228..591941 /gene="gmuR" /locus_tag="BSU_05850" /old_locus_tag="BSU05850" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18177310" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18177310; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (GntR family)" /protein_id="NP_388466.1" /db_xref="EnsemblGenomes-Gn:BSU05850" /db_xref="EnsemblGenomes-Tr:CAB12404" /db_xref="GOA:O05509" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR011663" /db_xref="InterPro:IPR028978" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12194" /db_xref="UniProtKB/Swiss-Prot:O05509" /translation="MNKYEIIANEMRNRIKNNVYPIDQPIPDEVSLAKEFNSSRMTMK RALDNLVAEGLLFRKRGHGTFIIQSAIQDDHVHVVSNEILGLTNLLKDKKIKSKVIQF EVQFPTEEVAAHLSIDQKTPVYYVVRLRIVEGEPYVLEKTYMPTHLIPGINDDVLHDS IYNHITNVLQLKIAGTHRKIRACKSDHIDQQHLGCKQDDPILEVEHVGFLDTGIPFEY SFSRHRHDKFVVTSVNIRR*" /label="gmuR CDS" gene 591228..591941 /gene="gmuR" /locus_tag="BSU_05850" /old_locus_tag="BSU05850" /label="gmuR gene" CDS 591970..592869 /gene="gmuE" /locus_tag="BSU_05860" /old_locus_tag="BSU05860" /EC_number="2.7.1.4" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15018644, 18177310, 21185308" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15018644, 18177310, 21185308; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ROK fructokinase; glucomannan utilization protein E" /protein_id="NP_388467.1" /db_xref="EnsemblGenomes-Gn:BSU05860" /db_xref="EnsemblGenomes-Tr:CAB12405" /db_xref="GOA:O05510" /db_xref="InterPro:IPR000600" /db_xref="PDB:1XC3" /db_xref="PDB:3LM9" /db_xref="PDB:3OHR" /db_xref="SubtiList:BG12195" /db_xref="UniProtKB/Swiss-Prot:O05510" /translation="MLGGIEAGGTKFVCAVGREDGTIIDRIEFPTKMPDETIEKVIQY FSQFSLQAIGIGSFGPVDNDKTSQTYGTITATPKAGWRHYPFLQTVKNEMKIPVGFST DVNAAALGEFLFGEAKGLDSCLYITIGTGIGAGAIVEGRLLQGLSHPEMGHIYIRRHP DDVYQGKCPYHGDCFEGLASGPAIEARWGKKAADLSDIAQVWELEGYYIAQALAQYIL ILAPKKIILGGGVMQQKQVFSYIYQYVPKIMNSYLDFSELSDDISDYIVPPRLGSNAG IIGTLVLAHQALQAEAASGEVRS*" /label="gmuE CDS" gene 591970..592869 /gene="gmuE" /locus_tag="BSU_05860" /old_locus_tag="BSU05860" /label="gmuE gene" CDS 592866..593813 /gene="gmuF" /locus_tag="BSU_05870" /old_locus_tag="BSU05870" /EC_number="5.3.1.8" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 10704478, 18177310, 3017192; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphohexomutase; cupin family" /protein_id="NP_388468.1" /db_xref="EnsemblGenomes-Gn:BSU05870" /db_xref="EnsemblGenomes-Tr:CAB12406" /db_xref="GOA:O05511" /db_xref="InterPro:IPR001250" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014628" /db_xref="InterPro:IPR014710" /db_xref="SubtiList:BG12196" /db_xref="UniProtKB/Swiss-Prot:O05511" /translation="MTHPLFLEPVFKERLWGGTKLRDAFGYAIPSQKTGECWAVSAHA HGSSSVKNGPLAGKTLDQVWKDHPEIFGFPDGKVFPLLVKLLDANMDLSVQVHPDDDY AKLHENGDLGKTECWYIIDCKDDAELILGHHASTKEEFKQRIESGDWNGLLRRIKIKP GDFFYVPSGTLHALCKGTLVLEIQQNSDTTYRVYDYDRCNDQGQKRTLHIEKAMEVIT IPHIDKVHTPEVKEVGNAEIIVYVQSDYFSVYKWKISGRAAFPSYQTYLLGSVLSGSG RIINNGIQYECNAGSHFILPAHFGEFTIEGTCEFMISHP*" /label="gmuF CDS" gene 592866..593813 /gene="gmuF" /locus_tag="BSU_05870" /old_locus_tag="BSU05870" /label="gmuF gene" CDS 593832..594920 /gene="gmuG" /locus_tag="BSU_05880" /old_locus_tag="BSU05880" /EC_number="3.2.1.78" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2694961, 7727534, 18177310, 28101462, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2694961, 7727534, 18177310, 28101462, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported mannan endo-1,4-beta-mannosidase" /protein_id="NP_388469.2" /db_xref="EnsemblGenomes-Gn:BSU05880" /db_xref="EnsemblGenomes-Tr:CAB12407" /db_xref="GOA:O05512" /db_xref="InterPro:IPR000805" /db_xref="InterPro:IPR016714" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR022790" /db_xref="PDB:2WHK" /db_xref="PDB:3CBW" /db_xref="SubtiList:BG12197" /db_xref="UniProtKB/Swiss-Prot:O05512" /translation="MFKKHTISLLIIFLLASAVLAKPIEAHTVSPVNPNAQQTTKTVM NWLAHLPNRTENRVLSGAFGGYSHDTFSMAEADRIRSATGQSPAIYGCDYARGWLETA NIEDSIDVSCNGDLMSYWKNGGIPQISLHLANPAFQSGHFKTPITNDQYKKILDSSTV EGKRLNAMLSKIADGLQELENQGVPVLFRPLHEMNGEWFWWGLTSYNQKDNERISLYK QLYKKIYHYMTDTRGLDHLIWVYSPDANRDFKTDFYPGASYVDIVGLDAYFQDAYSIN GYDQLTALNKPFAFTEVGPQTANGSFDYSLFINAIKQKYPKTIYFLAWNDEWSAAVNK GASALYHDSWTLNKGEIWNGDSLTPIVE*" /label="gmuG CDS" gene 593832..594920 /gene="gmuG" /locus_tag="BSU_05880" /old_locus_tag="BSU05880" /label="gmuG gene" downshifts 594914 /Source="Nicolas_upshifts" /id="D284" /incds=0 /nref=1 /ntot=17 /MaxReadThrough="1.56881" /MaxDrop="2.87204" /score="7.63230089" /energy="-5.4" /TU="NA" /idTUdmin="U454" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(594981..595709) /gene="ydhUc" /locus_tag="BSU_05890" /old_locus_tag="BSU05890" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; Product type e : enzyme" /pseudo /codon_start=1 /transl_table=11 /product="Mn catalase fragment; C-terminal part of YhdU" /db_xref="SubtiList:BG12198" /translation="FFQSSNFRGKQKQYRDLLRGIFLEEIAHVELVQNTINALLDESG GEGVGSQGTDQAPLDEAVKHANPHHYIIGAQSSLPVDAGGNPWNGSWVYNHGNLITDL LDNLLLESTGVLQKTRIYEMSSNQTFRETLAFLIVRDNAHQNAFAKALETLGVEWAKL LPVPNYDINKYPECRKYVELGYHNTHFNFRLDETRISEIYQGKSPSRNGGELQVIDPP AGFPVPVLPEIPNEHSPGLGDMNA*" /label="ydhUc CDS" gene complement(594981..595709) /gene="ydhUc" /locus_tag="BSU_05890" /old_locus_tag="BSU05890" /pseudo /label="ydhUc gene" downshifts complement(595031) /Source="Nicolas_upshifts" /id="D285" /incds=0 /nref=13 /ntot=37 /MaxReadThrough="1.1517" /MaxDrop="5.0503" /score="0.317473754" /energy="-17.6" /TU="NA" /idTUdmin="U456" /TUdmin=3 /isTUend="TRUE" /label="downshifts" CDS complement(595640..595834) /gene="ydhUn" /locus_tag="BSU_05899" /old_locus_tag="BSU05899" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; Product type e : enzyme" /pseudo /codon_start=1 /transl_table=11 /product="Mn catalase fragment; N-terminal part of YhdU" /translation="MYYYKEELINIIKPDKPDPAAAKVLQEILGGHYGEMRTMMQFFS KALISEESRNSTAICFAAFF*" /label="ydhUn CDS" gene complement(595640..595834) /gene="ydhUn" /locus_tag="BSU_05899" /old_locus_tag="BSU05899" /pseudo /label="ydhUn gene" promotor_-10 complement(595867..595878) /Source="Nicolas_upshift_promotors" /id="U456" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=907 /SigmaFactorBS="ttattttcttctttcacgccttcccatgcttatcatgTATAT ATtttatctcatcttACAAATAATATAagaaaatctcttaagaagaaatgaggcgtgt t" /listShort="ydhU, ydhU" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(595875) /Source="Nicolas_upshifts" /id="U456" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=907 /SigmaFactorBS="ttattttcttctttcacgccttcccatgcttatcatgTATAT ATtttatctcatcttACAAATAATATAagaaaatctcttaagaagaaatgaggcgtgt t" /listShort="ydhU, ydhU" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(595892..595898) /Source="Nicolas_upshift_promotors" /id="U456" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=907 /SigmaFactorBS="ttattttcttctttcacgccttcccatgcttatcatgTATAT ATtttatctcatcttACAAATAATATAagaaaatctcttaagaagaaatgaggcgtgt t" /listShort="ydhU, ydhU" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 595953..595960 /Source="Nicolas_upshift_promotors" /id="U457" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2625 /SigmaFactorBS="cgtgaaagaagaaaataaaaaaatacaggaaaagtGTTGACC AaataaaacaggcaTGGTATATTATTAAACGTCGctgatgaacagcgtgaaacaaaac a" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 595974..595993 /Source="Nicolas_upshift_promotors" /id="U457" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2625 /SigmaFactorBS="cgtgaaagaagaaaataaaaaaatacaggaaaagtGTTGACC AaataaaacaggcaTGGTATATTATTAAACGTCGctgatgaacagcgtgaaacaaaac a" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="promotor_-10" promotor_no_box 595976..596076 /Source="Nicolas_upshift_promotors" /id="U458" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.604395604395604" /psig="0.0919080919080919" /xcortree=1636 /SigmaFactorBS="gtatattattaaacgtcgctgatgaacagcgtgaaacaaaac agaaaaacaaaaaagttttcctaaggtgtttacaagattttaaaaatgtgtataataa g" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 595978 /Source="Nicolas_upshifts" /id="U457" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2625 /SigmaFactorBS="cgtgaaagaagaaaataaaaaaatacaggaaaagtGTTGACC AaataaaacaggcaTGGTATATTATTAAACGTCGctgatgaacagcgtgaaacaaaac a" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(596024) /Source="Nicolas_upshifts" /id="D286" /incds=0 /nref=1 /ntot=54 /MaxReadThrough="2.24619" /MaxDrop="4.20389" /score="11.9939391" /energy="-9" /TU="NA" /idTUdmin="U456" /TUdmin="-990" /isTUend="FALSE" /label="downshifts" upshifts 596036 /Source="Nicolas_upshifts" /id="U458" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.604395604395604" /psig="0.0919080919080919" /xcortree=1636 /SigmaFactorBS="gtatattattaaacgtcgctgatgaacagcgtgaaacaaaac agaaaaacaaaaaagttttcctaaggtgtttacaagattttaaaaatgtgtataataa g" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 596044..596051 /Source="Nicolas_upshift_promotors" /id="U459" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.418581418581419" /psig="0.96003996003996" /xcortree=1634 /SigmaFactorBS="aaaaacaaaaaagttttcctaaggTGTTTACAagattttaaa aatGTGTATAATAAGAAAAGTCGaattgaaaaagattcgaaaaaacattaaaaaactt c" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 596065..596084 /Source="Nicolas_upshift_promotors" /id="U459" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.418581418581419" /psig="0.96003996003996" /xcortree=1634 /SigmaFactorBS="aaaaacaaaaaagttttcctaaggTGTTTACAagattttaaa aatGTGTATAATAAGAAAAGTCGaattgaaaaagattcgaaaaaacattaaaaaactt c" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 596080..596167 /Source="Nicolas_S_feature" /locus_tag="new_635022_635109" /HighExp="LBGstat, C30, Cold, Heat, Oxctl, T-1.10H, T-0.40H, T-1.40H, UNK1, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-, SigA" /TUshortPSig="0.96, 0.0919, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S204" upshifts 596080 /Source="Nicolas_upshifts" /id="U459" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.418581418581419" /psig="0.96003996003996" /xcortree=1634 /SigmaFactorBS="aaaaacaaaaaagttttcctaaggTGTTTACAagattttaaa aatGTGTATAATAAGAAAAGTCGaattgaaaaagattcgaaaaaacattaaaaaactt c" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="upshifts" tRNA 596168..596244 /gene="trnE-Arg" /locus_tag="BSU_tRNA_79" /product="tRNA-Arg" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnE-Arg tRNA" gene 596168..596244 /gene="trnE-Arg" /locus_tag="BSU_tRNA_79" /label="trnE-Arg gene" tRNA 596258..596331 /gene="trnE-Gly" /locus_tag="BSU_tRNA_80" /product="tRNA-Gly" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gly(UCC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnE-Gly tRNA" gene 596258..596331 /gene="trnE-Gly" /locus_tag="BSU_tRNA_80" /label="trnE-Gly gene" rRNA 596491..598045 /gene="rrnE-16S" /locus_tag="BSU_rRNA_30" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnE-16S rRNA" gene 596491..598045 /gene="rrnE-16S" /locus_tag="BSU_rRNA_30" /label="rrnE-16S gene" rRNA 598213..601140 /gene="rrnE-23S" /locus_tag="BSU_rRNA_12" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnE-23S rRNA" gene 598213..601140 /gene="rrnE-23S" /locus_tag="BSU_rRNA_12" /label="rrnE-23S gene" rRNA 601196..601312 /gene="rrnE-5S" /locus_tag="BSU_rRNA_13" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnE-5S rRNA" gene 601196..601312 /gene="rrnE-5S" /locus_tag="BSU_rRNA_13" /label="rrnE-5S gene" tRNA 601326..601402 /gene="trnE-Met" /locus_tag="BSU_tRNA_21" /product="tRNA-Met" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Met(CAU); Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnE-Met tRNA" gene 601326..601402 /gene="trnE-Met" /locus_tag="BSU_tRNA_21" /label="trnE-Met gene" tRNA 601463..601539 /gene="trnE-Asp" /locus_tag="BSU_tRNA_22" /product="tRNA-Asp" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Asp(GUC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnE-Asp tRNA" gene 601463..601539 /gene="trnE-Asp" /locus_tag="BSU_tRNA_22" /label="trnE-Asp gene" downshifts 601536 /Source="Nicolas_upshifts" /id="D287" /incds=0 /nref=38 /ntot=211 /MaxReadThrough="6.00554" /MaxDrop="5.14761" /score="7.63230089" /energy="-5.4" /TU="NA" /idTUdmin="U460" /TUdmin="-3784" /isTUend="FALSE" /label="downshifts" promotor_-35 601640..601644 /Source="Nicolas_upshift_promotors" /id="U460" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=2461 /SigmaFactorBS="tggtgtcatagccaagctttctttatatcgggaacaTCTTGg atattccagcaaaaTTCGATAAACTAGGAAGAGCacaaataggcataagcagggttga a" /listShort="thiL, ydiB, ydiC, rimI, gcp" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 601660..601679 /Source="Nicolas_upshift_promotors" /id="U460" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=2461 /SigmaFactorBS="tggtgtcatagccaagctttctttatatcgggaacaTCTTGg atattccagcaaaaTTCGATAAACTAGGAAGAGCacaaataggcataagcagggttga a" /listShort="thiL, ydiB, ydiC, rimI, gcp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 601664 /Source="Nicolas_upshifts" /id="U460" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=2461 /SigmaFactorBS="tggtgtcatagccaagctttctttatatcgggaacaTCTTGg atattccagcaaaaTTCGATAAACTAGGAAGAGCacaaataggcataagcagggttga a" /listShort="thiL, ydiB, ydiC, rimI, gcp" /GFF_Attribute="listLong" /label="upshifts" CDS 601720..602697 /gene="thiL" /locus_tag="BSU_05900" /old_locus_tag="BSU05900" /EC_number="2.7.4.16" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16291685, 26443755; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thiamine-monophosphate kinase" /protein_id="NP_388471.1" /db_xref="EnsemblGenomes-Gn:BSU05900" /db_xref="EnsemblGenomes-Tr:CAB12409" /db_xref="GOA:O05514" /db_xref="InterPro:IPR006283" /db_xref="InterPro:IPR010918" /db_xref="InterPro:IPR016188" /db_xref="InterPro:IPR036676" /db_xref="InterPro:IPR036921" /db_xref="SubtiList:BG10693" /db_xref="UniProtKB/Swiss-Prot:O05514" /translation="MDEFDLIHSITPRTIHHSSVDVGIGDDAALYTAKHGVQEIVCVD TMVEDVHFKLHYSSPEDIGYKALAVNISDIAAMGGIPKFYLVSLAVPSKWTESEIKAM YEGMNELAKLYHMDLIGGDTVSTADKLVVTVTVIGEIEKGQACLRSLAKPNDIVFVTG EIGSSAAGLSLLLEETNPQNSSVETDYFIHRHKRPEPRVSVGRLCSIFKRAALNDVSD GLASELNEIAEASCVSIEIVESMLPIHSDLPKLHPNWKEWALFGGEDFELTGTVSNEE WEVLKQECAALHLPITKIGYVREKTKSKVILKTDQTSMILEKKGYNHFK*" /label="thiL CDS" gene 601720..602697 /gene="thiL" /locus_tag="BSU_05900" /old_locus_tag="BSU05900" /label="thiL gene" CDS 602712..603188 /gene="tsaE" /locus_tag="BSU_05910" /old_locus_tag="BSU05910" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 17005971, 19246765, 19376873, 19578062, 20701780, 20824107, 21183954, 21285948, 22378793, 23072323" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17005971, 19246765, 19376873, 19578062, 20701780, 20824107, 21183954, 21285948, 22378793, 23072323; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="tRNA(NNU) t(6)A37 threonylcarbamoyladenosine modification; ADP binding protein" /protein_id="NP_388472.1" /db_xref="EnsemblGenomes-Gn:BSU05910" /db_xref="EnsemblGenomes-Tr:CAB12410" /db_xref="GOA:O05515" /db_xref="InterPro:IPR003442" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12199" /db_xref="UniProtKB/Swiss-Prot:O05515" /translation="MKQLKWRTVNPEETKAIAKLTAAFAKPGDVLTLEGDLGAGKTTF TKGFAEGLGITRIVNSPTFTIIKEYNDGVLPLYHMDVYRMEDESEDLGLDEYFHGQGV CLVEWAHLIEEQLPQERLQIVIKRAGDDEREITFTAVGNRYEMLCEELSRHDNISN*" /label="tsaE CDS" gene 602712..603188 /gene="tsaE" /locus_tag="BSU_05910" /old_locus_tag="BSU05910" /label="tsaE gene" CDS 603169..603858 /gene="tsaB" /locus_tag="BSU_05920" /old_locus_tag="BSU05920" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12682299, 17005971, 20944216, 19376873, 19578062, 20701780, 20824107, 21183954, 21285948, 22378793, 23072323" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17005971, 20944216, 19376873, 19578062, 20701780, 20824107, 21183954, 21285948, 22378793, 23072323; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="tRNA(NNU) t(6)A37 threonylcarbamoyladenosine modification; protease involved in TsaD function" /protein_id="NP_388473.1" /db_xref="EnsemblGenomes-Gn:BSU05920" /db_xref="EnsemblGenomes-Tr:CAB12411" /db_xref="GOA:O05516" /db_xref="InterPro:IPR000905" /db_xref="InterPro:IPR022496" /db_xref="SubtiList:BG12200" /db_xref="UniProtKB/Swiss-Prot:O05516" /translation="MTILAIDTSNYTLGIALLREDTVIAEYITYLKKNHSVRAMPAVH SLLNDCDMAPQDLSKIVVAKGPGSYTGVRIGVTLAKTLAWSLDIPISAVSSLETLAAN GRHFDGLISPIFDARRGQVYTGLYQYKNGLLEQVVPDQNVMLADWLEMLKEKDRPVLF LGHDTSLHKQMIEDVLGTKGFIGTAAQHNPRPSELAFLGKEKEAADVHGLVPDYLRLA EAEAKWIESQK*" /label="tsaB CDS" gene 603169..603858 /gene="tsaB" /locus_tag="BSU_05920" /old_locus_tag="BSU05920" /label="tsaB gene" CDS 603868..604323 /gene="rimI" /locus_tag="BSU_05930" /old_locus_tag="BSU05930" /EC_number="2.3.1.267" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2828880; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ribosomal protein S18 alanine N-acetyltransferase" /protein_id="NP_388474.1" /db_xref="EnsemblGenomes-Gn:BSU05930" /db_xref="EnsemblGenomes-Tr:CAB12412" /db_xref="GOA:O05517" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR006464" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG12201" /db_xref="UniProtKB/Swiss-Prot:O05517" /translation="MKTKAAVRNMRLEDIDHVYEIEASSFTSPWTKDSFYHELLENPY AHYLVIEKDGHLAGYCGIWIVMDDAQITNIAIKPEYRGQSLGETLFRSAVELCKEKDA RRLSLEVRVSNHPAQGLYKKFGMQPGGIRKNYYTDNGEDALIMWVTINE*" /label="rimI CDS" gene 603868..604323 /gene="rimI" /locus_tag="BSU_05930" /old_locus_tag="BSU05930" /label="rimI gene" CDS 604316..605356 /gene="tsaD" /locus_tag="BSU_05940" /old_locus_tag="BSU05940" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11073929, 12682299, 9743119, 20824107, 21625506, 21873492, 19376873, 19578062, 20701780, 20824107, 21183954, 21285948, 22378793; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA(NNU) t(6)A37 threonylcarbamoyladenosine modification; glycation binding protein" /protein_id="NP_388475.1" /db_xref="EnsemblGenomes-Gn:BSU05940" /db_xref="EnsemblGenomes-Tr:CAB12413" /db_xref="GOA:O05518" /db_xref="InterPro:IPR000905" /db_xref="InterPro:IPR017860" /db_xref="InterPro:IPR017861" /db_xref="InterPro:IPR022450" /db_xref="SubtiList:BG12202" /db_xref="UniProtKB/Swiss-Prot:O05518" /translation="MSEQKDMYVLGIETSCDETAAAIVKNGKEIISNVVASQIESHKR FGGVVPEIASRHHVEQITLVIEEAFRKAGMTYSDIDAIAVTEGPGLVGALLIGVNAAK ALSFAYNIPLVGVHHIAGHIYANRLVEDIVFPALALVVSGGHTELVYMKEHGSFEVIG ETLDDAAGEAYDKVARTMGLPYPGGPQIDKLAEKGNDNIPLPRAWLEEGSYNFSFSGL KSAVINTLHNASQKGQEIAPEDLSASFQNSVIDVLVTKTARAAKEYDVKQVLLAGGVA ANRGLRAALEKEFAQHEGITLVIPPLALCTDNAAMIAAAGTIAFEKGIRGAYDMNGQP GLELTSYQSLTR*" /label="tsaD CDS" gene 604316..605356 /gene="tsaD" /locus_tag="BSU_05940" /old_locus_tag="BSU05940" /label="tsaD gene" downshifts 605320 /Source="Nicolas_upshifts" /id="D288" /incds=0 /nref=39 /ntot=222 /MaxReadThrough="3.15518" /MaxDrop="4.65228" /score="3.97936019" /energy="-10.1" /TU="NA" /idTUdmin="U460" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(605586..607514) /gene="ydiF" /locus_tag="BSU_05950" /old_locus_tag="BSU05950" /function="16.8: Protect" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11916677, 16109936, 24389466; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative energy-sensing inhibitor of translation" /protein_id="NP_388476.2" /db_xref="EnsemblGenomes-Gn:BSU05950" /db_xref="EnsemblGenomes-Tr:CAB12414" /db_xref="GOA:O05519" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032524" /db_xref="InterPro:IPR032781" /db_xref="SubtiList:BG12203" /db_xref="UniProtKB/Swiss-Prot:O05519" /translation="MMILQVNQLSKSFGADTILNNIKLEVRNRDRIAIVGRNGAGKST LLKIIAGQLSYEKGEIIKPKDITMGYLAQHTGLDSKLTIKEELLTVFDHLKAMEKEMR AMEEKMAAADPGELESIMKTYDRLQQEFKDKGGYQYEADVRSVLHGLGFSHFDDSTQV QSLSGGQKTRLALGKLLLTQPDLLILDEPTNHLDIDTLTWLEHYLQGYSGAILIVSHD RYFLDKVVNQVYEVSRAESKKYHGNYSAYLDQKAAQYEKDLKMYEKQQDEIAKLQDFV DRNLARASTTKRAQSRRKQLERMDVMSKPLGDEKSANFHFDITKQSGNEVLRVQDLTI SYENQPPLLTEVSFMLTRGESAALVGPNGIGKSTLLKTLIDTLKPDQGTISYGSNVSV GYYDQEQAELTSSKRVLDELWDEYPGLPEKEIRTCLGNFLFSGDDVLKPVHSLSGGEK ARLALAKLMLQKANFLILDEPTNHLDLDSKEVLENALIDYPGTLLFVSHDRYFINRIA TRVLELSSSHIEEYLGDYDYYTEKKTEQLELEKMNQQEETDKTPATVKSDSKRSYEEE KEWKKKERQRLRRIEEIETTVQTIEENISRNDELLCDPEVYQDHEKVQAIHADNEKLN QELESLLSEWEELSTEED*" /label="ydiF CDS" gene complement(605586..607514) /gene="ydiF" /locus_tag="BSU_05950" /old_locus_tag="BSU05950" /label="ydiF gene" downshifts complement(605603) /Source="Nicolas_upshifts" /id="D289" /incds=0 /nref=170 /ntot=266 /MaxReadThrough="1.32926" /MaxDrop="5.81869" /score="16.702581" /energy="-12.6" /TU="NA" /idTUdmin="U463" /TUdmin="-9" /isTUend="TRUE" /label="downshifts" misc_feature 607266..607285 /Source="Nicolas_upshift_promotors" /id="U461" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.821178821178821" /psig="0.98901098901099" /xcortree=2080 /SigmaFactorBS="tccttttccattgcttttaagtggtcaaaaacagtcagcagc tcttctttTATGGTAAGCTTAGAATCCAagccagtatgctgggcgagatatcccattg t" /listShort="S205, S206, moaC, rex, tatAY, tatCY" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 607276 /Source="Nicolas_upshifts" /id="U461" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.821178821178821" /psig="0.98901098901099" /xcortree=2080 /SigmaFactorBS="tccttttccattgcttttaagtggtcaaaaacagtcagcagc tcttctttTATGGTAAGCTTAGAATCCAagccagtatgctgggcgagatatcccattg t" /listShort="S205, S206, moaC, rex, tatAY, tatCY" /GFF_Attribute="listLong" /label="upshifts" S_feature 607278..607467 /Source="Nicolas_S_feature" /locus_tag="new_646220_646409" /HighExp="Diami, H2O2, dia5, Paraq, G135, G180, G150, Cold, dia15, BC" /AntisenseName="ydiF" /AntisenseCor="0.47406689574609401" /AntisenseRegPval="-15.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S205" promotor_-35 607432..607439 /Source="Nicolas_upshift_promotors" /id="U462" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig="0.997002997002997" /xcortree=2055 /SigmaFactorBS="ctacaatggcgatgcgatcacgaTTTCTGACttccagcttta taTTGTTTAAAATAGTATCAGCaccaaatgatttggacagctgattaacttgtaagat c" /listShort="S206, moaC, rex, tatAY, tatCY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 607453..607472 /Source="Nicolas_upshift_promotors" /id="U462" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig="0.997002997002997" /xcortree=2055 /SigmaFactorBS="ctacaatggcgatgcgatcacgaTTTCTGACttccagcttta taTTGTTTAAAATAGTATCAGCaccaaatgatttggacagctgattaacttgtaagat c" /listShort="S206, moaC, rex, tatAY, tatCY" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 607469..607639 /Source="Nicolas_S_feature" /locus_tag="new_646411_646581" /HighExp="Diami, dia5, dia15, H2O2, Etha, G180, G150, Oxctl, Mt0, Paraq" /AntisenseName="ydiF" /AntisenseCor="0.63697451027099605" /AntisenseRegPval="-31.3" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S206" upshifts 607469 /Source="Nicolas_upshifts" /id="U462" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig="0.997002997002997" /xcortree=2055 /SigmaFactorBS="ctacaatggcgatgcgatcacgaTTTCTGACttccagcttta taTTGTTTAAAATAGTATCAGCaccaaatgatttggacagctgattaacttgtaagat c" /listShort="S206, moaC, rex, tatAY, tatCY" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(607534..607553) /Source="Nicolas_upshift_promotors" /id="U463" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=2085 /SigmaFactorBS="tttcttctctatgtcttatatggccaatgtatTGTTTGCTga cttctggttcaTAAGCTACACTTAACTTATTatagcagaggtgaaataatatgatgat c" /listShort="ydiF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(607546) /Source="Nicolas_upshifts" /id="U463" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=2085 /SigmaFactorBS="tttcttctctatgtcttatatggccaatgtatTGTTTGCTga cttctggttcaTAAGCTACACTTAACTTATTatagcagaggtgaaataatatgatgat c" /listShort="ydiF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(607567..607574) /Source="Nicolas_upshift_promotors" /id="U463" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=2085 /SigmaFactorBS="tttcttctctatgtcttatatggccaatgtatTGTTTGCTga cttctggttcaTAAGCTACACTTAACTTATTatagcagaggtgaaataatatgatgat c" /listShort="ydiF" /GFF_Attribute="listLong" /label="promotor_-35" CDS 607640..608152 /gene="moaC" /locus_tag="BSU_05960" /old_locus_tag="BSU05960" /EC_number="4.6.1.17" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10903949, 16632608, 18607082, 20606263, 25941396, 26575208; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="molybdenum cofactor biosynthesis protein C" /protein_id="NP_388477.1" /db_xref="EnsemblGenomes-Gn:BSU05960" /db_xref="EnsemblGenomes-Tr:CAB12415" /db_xref="GOA:O05520" /db_xref="InterPro:IPR002820" /db_xref="InterPro:IPR023045" /db_xref="InterPro:IPR036522" /db_xref="SubtiList:BG12204" /db_xref="UniProtKB/Swiss-Prot:O05520" /translation="MNGFSHFNEQGRAQMVDISEKSSTVRTAAAVSSVHMKNEVYEKI QSHDIGKGDVLAVAQVAGIMAAKQTSNIIPMCHPLSLSGVDISFDWKIKEAEVILHIK AQVKTKGSTGVEMEALTSASVCALTVYDMCKALDKGMVIGPTFLLEKTGGKNGDFKRE LSEYNLEDQK*" /label="moaC CDS" gene 607640..608152 /gene="moaC" /locus_tag="BSU_05960" /old_locus_tag="BSU05960" /label="moaC gene" CDS 608149..608796 /gene="rex" /locus_tag="BSU_05970" /old_locus_tag="BSU05970" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15231791, 16207915, 17015645, 17322317, 18485070, 21402078, 23046954, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15231791, 16207915, 17015645, 17322317, 18485070, 21402078, 23046954, 26735940; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcription repressor of cydABCD and yjlC-ndh expression" /protein_id="NP_388478.1" /db_xref="EnsemblGenomes-Gn:BSU05970" /db_xref="EnsemblGenomes-Tr:CAB12416" /db_xref="GOA:O05521" /db_xref="InterPro:IPR003781" /db_xref="InterPro:IPR009718" /db_xref="InterPro:IPR022876" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2VT2" /db_xref="PDB:2VT3" /db_xref="SubtiList:BG12205" /db_xref="UniProtKB/Swiss-Prot:O05521" /translation="MNKDQSKIPQATAKRLPLYYRFLKNLHASGKQRVSSAELSDAVK VDSATIRRDFSYFGALGKKGYGYNVDYLLSFFRKTLDQDEMTDVILIGVGNLGTAFLH YNFTKNNNTKISMAFDINESKIGTEVGGVPVYNLDDLEQHVKDESVAILTVPAVAAQS ITDRLVALGIKGILNFTPARLNVPEHIRIHHIDLAVELQSLVYFLKHYSVLEEIE*" /label="rex CDS" gene 608149..608796 /gene="rex" /locus_tag="BSU_05970" /old_locus_tag="BSU05970" /label="rex gene" promotor_no_box 608626..608726 /Source="Nicolas_upshift_promotors" /id="U464" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.386613386613387" /psig="0.386613386613387" /xcortree=511 /SigmaFactorBS="tccattacagacagattggtcgcattaggaatcaagggaatc cttaattttacgccggcccgtttgaatgtgccggaacacattcgaattcatcatatag a" /listShort="tatAY, tatCY" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 608686 /Source="Nicolas_upshifts" /id="U464" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.386613386613387" /psig="0.386613386613387" /xcortree=511 /SigmaFactorBS="tccattacagacagattggtcgcattaggaatcaagggaatc cttaattttacgccggcccgtttgaatgtgccggaacacattcgaattcatcatatag a" /listShort="tatAY, tatCY" /GFF_Attribute="listLong" /label="upshifts" CDS 608818..608991 /gene="tatAY" /locus_tag="BSU_05980" /old_locus_tag="BSU05980" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15187182, 19049517, 22041895, 22544248, 24652282, 26239117, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15187182, 19049517, 22041895, 22544248, 24652282, 26239117, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="component of the twin-arginine pre-protein translocation pathway" /protein_id="NP_388479.1" /db_xref="EnsemblGenomes-Gn:BSU05980" /db_xref="EnsemblGenomes-Tr:CAB12417" /db_xref="GOA:O05522" /db_xref="InterPro:IPR003369" /db_xref="InterPro:IPR006312" /db_xref="SubtiList:BG12206" /db_xref="UniProtKB/Swiss-Prot:O05522" /translation="MPIGPGSLAVIAIVALIIFGPKKLPELGKAAGDTLREFKNATKG LTSDEEEKKKEDQ*" /label="tatAY CDS" gene 608818..608991 /gene="tatAY" /locus_tag="BSU_05980" /old_locus_tag="BSU05980" /label="tatAY gene" CDS 608998..609762 /gene="tatCY" /locus_tag="BSU_05990" /old_locus_tag="BSU05990" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11007775, 15187182, 15849754, 16850406, 19049517, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11007775, 15187182, 15849754, 16850406, 19049517, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="component of the twin-arginine pre-protein translocation pathway" /protein_id="NP_388480.1" /db_xref="EnsemblGenomes-Gn:BSU05990" /db_xref="EnsemblGenomes-Tr:CAB12418" /db_xref="GOA:O05523" /db_xref="InterPro:IPR002033" /db_xref="InterPro:IPR019820" /db_xref="SubtiList:BG12207" /db_xref="UniProtKB/Swiss-Prot:O05523" /translation="MTRMKVNQMSLLEHIAELRKRLLIVALAFVVFFIAGFFLAKPII VYLQETDEAKQLTLNAFNLTDPLYVFMQFAFIIGIVLTSPVILYQLWAFVSPGLYEKE RKVTLSYIPVSILLFLAGLSFSYYILFPFVVDFMKRISQDLNVNQVIGINEYFHFLLQ LTIPFGLLFQMPVILMFLTRLGIVTPMFLAKIRKYAYFTLLVIAALITPPELLSHMMV TVPLLILYEISILISKAAYRKAQKSSAADRDVSSGQ*" /label="tatCY CDS" gene 608998..609762 /gene="tatCY" /locus_tag="BSU_05990" /old_locus_tag="BSU05990" /label="tatCY gene" downshifts 609742 /Source="Nicolas_upshifts" /id="D290" /incds=0 /nref=151 /ntot=251 /MaxReadThrough="4.01237" /MaxDrop="6.80817" /score="19.4098216" /energy="-12.7" /TU="NA" /idTUdmin="U461" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(609800..609991) /gene="ydiK" /locus_tag="BSU_06000" /old_locus_tag="BSU06000" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388481.1" /db_xref="EnsemblGenomes-Gn:BSU06000" /db_xref="EnsemblGenomes-Tr:CAB12419" /db_xref="GOA:O05524" /db_xref="InterPro:IPR025426" /db_xref="SubtiList:BG12208" /db_xref="UniProtKB/Swiss-Prot:O05524" /translation="MRNPVVWGMIYFAVGCIFTYLAASSPGSMWSFYSILLMVFAAYN ISISFKMFAFSFKIKKNQK*" /label="ydiK CDS" gene complement(609800..609991) /gene="ydiK" /locus_tag="BSU_06000" /old_locus_tag="BSU06000" /label="ydiK gene" downshifts complement(609817) /Source="Nicolas_upshifts" /id="D291" /incds=0 /nref=211 /ntot=258 /MaxReadThrough="0.81338" /MaxDrop="6.43897" /score="25.5376889" /energy="-12.7" /TU="NA" /idTUdmin="U467" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" CDS complement(609988..610722) /gene="ydiL" /locus_tag="BSU_06010" /old_locus_tag="BSU06010" /EC_number="3.4.-.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane protease" /protein_id="NP_388482.1" /db_xref="EnsemblGenomes-Gn:BSU06010" /db_xref="EnsemblGenomes-Tr:CAB12420" /db_xref="GOA:O05525" /db_xref="InterPro:IPR003675" /db_xref="SubtiList:BG12209" /db_xref="UniProtKB/Swiss-Prot:O05525" /translation="MRKQYWFIILTYIIMQFSALIAIPLLFKFGYAGGQPTDENMLHA QGLWSVISFIACLVVVLLILRTVPKETLRNGQKDSIGLSILWAIAGFFIALFSQGIAG SIEYYVFGIGRESENTQAILDVIQAVPLMIIVSSIVGPILEEIIFRKIIFGALYEKTN FFFAGLISSVIFGIVHADLKHLLLYTAMGFTFAFLYARTKRIWVPIFAHLMMNTFVVI MQLEPVRNYLEQQSTQMQLIIGGLFL*" /label="ydiL CDS" gene complement(609988..610722) /gene="ydiL" /locus_tag="BSU_06010" /old_locus_tag="BSU06010" /label="ydiL gene" promotor_-35 610380..610385 /Source="Nicolas_upshift_promotors" /id="U465" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.952047952047952" /psig="0.952047952047952" /xcortree=1034 /SigmaFactorBS="tgcctgaatgacatccagaatcgcttgtgtattttctgATTC TCttccgatgccaaaaACATAATATTCAATAGAGCctgctattccttgagagaaaagg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 610400..610418 /Source="Nicolas_upshift_promotors" /id="U465" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.952047952047952" /psig="0.952047952047952" /xcortree=1034 /SigmaFactorBS="tgcctgaatgacatccagaatcgcttgtgtattttctgATTC TCttccgatgccaaaaACATAATATTCAATAGAGCctgctattccttgagagaaaagg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 610402 /Source="Nicolas_upshifts" /id="U465" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.952047952047952" /psig="0.952047952047952" /xcortree=1034 /SigmaFactorBS="tgcctgaatgacatccagaatcgcttgtgtattttctgATTC TCttccgatgccaaaaACATAATATTCAATAGAGCctgctattccttgagagaaaagg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 610721..610722 /Source="Nicolas_upshift_promotors" /id="U466" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.508491508491508" /psig="0.237762237762238" /xcortree=1461 /SigmaFactorBS="aaaataataaaccaatactgttttctcAAatggtatgtACTC CTTTGTTAAGTgggtttcgttcatctacagctattgtaacataatcggtacgggggtg a" /listShort="S207" /listLong="S208, groES, groEL, S209, S210, ydiM, S211, ydzU, ydzV, S212, S213, ydiO, ydiP" /label="promotor_-35" promotor_-10 610732..610746 /Source="Nicolas_upshift_promotors" /id="U466" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.508491508491508" /psig="0.237762237762238" /xcortree=1461 /SigmaFactorBS="aaaataataaaccaatactgttttctcAAatggtatgtACTC CTTTGTTAAGTgggtttcgttcatctacagctattgtaacataatcggtacgggggtg a" /listShort="S207" /listLong="S208, groES, groEL, S209, S210, ydiM, S211, ydzU, ydzV, S212, S213, ydiO, ydiP" /label="promotor_-10" upshifts 610754 /Source="Nicolas_upshifts" /id="U466" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.508491508491508" /psig="0.237762237762238" /xcortree=1461 /SigmaFactorBS="aaaataataaaccaatactgttttctcAAatggtatgtACTC CTTTGTTAAGTgggtttcgttcatctacagctattgtaacataatcggtacgggggtg a" /listShort="S207" /listLong="S208, groES, groEL, S209, S210, ydiM, S211, ydzU, ydzV, S212, S213, ydiO, ydiP" /label="upshifts" promotor_-10 complement(610759..610778) /Source="Nicolas_upshift_promotors" /id="U467" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=2332 /SigmaFactorBS="tcacgcttacatcattcttttccgctcccttttccgttagct TTTTCAcccccgtaccgatTATGTTACAATAGCTGTAGAtgaacgaaacccacttaac a" /listShort="ydiL, ydiK" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 610776..610884 /Source="Nicolas_S_feature" /locus_tag="new_649718_649826" /HighExp="S4, S5, H2O2, S3, S8, S6, Diami, Oxctl, G180, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.238" /TUlongSig="NA" /TUlongPSig="NA" /label="S207" upshifts complement(610779) /Source="Nicolas_upshifts" /id="U467" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=2332 /SigmaFactorBS="tcacgcttacatcattcttttccgctcccttttccgttagct TTTTCAcccccgtaccgatTATGTTACAATAGCTGTAGAtgaacgaaacccacttaac a" /listShort="ydiL, ydiK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(610792..610797) /Source="Nicolas_upshift_promotors" /id="U467" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=2332 /SigmaFactorBS="tcacgcttacatcattcttttccgctcccttttccgttagct TTTTCAcccccgtaccgatTATGTTACAATAGCTGTAGAtgaacgaaacccacttaac a" /listShort="ydiL, ydiK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 610858..610864 /Source="Nicolas_upshift_promotors" /id="U468" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.495504495504495" /psig="0.999000999001" /xcortree=2363 /SigmaFactorBS="tgatgtaagcgtgaaaaattttttatcttatcACTTGAAatt ggaagggagaTTCTTTATTATAAGAATTGTgttagcactctttagtgctgagtgctaa a" /listShort="S208, groES, groEL, S209, S210, ydiM, S211, ydzU, ydzV, S212, S213, ydiO, ydiP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 610878..610897 /Source="Nicolas_upshift_promotors" /id="U468" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.495504495504495" /psig="0.999000999001" /xcortree=2363 /SigmaFactorBS="tgatgtaagcgtgaaaaattttttatcttatcACTTGAAatt ggaagggagaTTCTTTATTATAAGAATTGTgttagcactctttagtgctgagtgctaa a" /listShort="S208, groES, groEL, S209, S210, ydiM, S211, ydzU, ydzV, S212, S213, ydiO, ydiP" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 610886..610960 /Source="Nicolas_S_feature" /locus_tag="new_649828_649902" /HighExp="HiTm, Etha, dia15, Heat, C90, dia5, LoTm, Lbexp, H2O2, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="Sig-" /TUlongPSig="0.238" /label="S208" upshifts 610886 /Source="Nicolas_upshifts" /id="U468" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.495504495504495" /psig="0.999000999001" /xcortree=2363 /SigmaFactorBS="tgatgtaagcgtgaaaaattttttatcttatcACTTGAAatt ggaagggagaTTCTTTATTATAAGAATTGTgttagcactctttagtgctgagtgctaa a" /listShort="S208, groES, groEL, S209, S210, ydiM, S211, ydzU, ydzV, S212, S213, ydiO, ydiP" /GFF_Attribute="listLong" /label="upshifts" CDS 610961..611245 /gene="groES" /locus_tag="BSU_06020" /old_locus_tag="BSU06020" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11407116, 17031040, 9303302" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11407116, 17031040, 9303302; Product type f: factor" /codon_start=1 /transl_table=11 /product="chaperonin small subunit" /protein_id="NP_388483.2" /db_xref="EnsemblGenomes-Gn:BSU06020" /db_xref="EnsemblGenomes-Tr:CAB12421" /db_xref="GOA:P28599" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR018369" /db_xref="InterPro:IPR020818" /db_xref="InterPro:IPR037124" /db_xref="SubtiList:BG10422" /db_xref="UniProtKB/Swiss-Prot:P28599" /translation="MLKPLGDRVVIELVESEEKTASGIVLPDSAKEKPQEGKIVAAGS GRVLESGERVALEVKEGDRIIFSKYAGTEVKYEGTEYLILRESDILAVIG*" /label="groES CDS" gene 610961..611245 /gene="groES" /locus_tag="BSU_06020" /old_locus_tag="BSU06020" /label="groES gene" CDS 611292..612926 /gene="groEL" /locus_tag="BSU_06030" /old_locus_tag="BSU06030" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9303302, 11407116, 17031040, 17420574, 22268681" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9303302, 11407116, 17031040, 17420574, 22268681; Product type f: factor" /codon_start=1 /transl_table=11 /product="chaperonin large subunit" /protein_id="NP_388484.1" /db_xref="EnsemblGenomes-Gn:BSU06030" /db_xref="EnsemblGenomes-Tr:CAB12422" /db_xref="GOA:P28598" /db_xref="InterPro:IPR001844" /db_xref="InterPro:IPR002423" /db_xref="InterPro:IPR018370" /db_xref="InterPro:IPR027409" /db_xref="InterPro:IPR027410" /db_xref="InterPro:IPR027413" /db_xref="SubtiList:BG10423" /db_xref="UniProtKB/Swiss-Prot:P28598" /translation="MAKEIKFSEEARRAMLRGVDALADAVKVTLGPKGRNVVLEKKFG SPLITNDGVTIAKEIELEDAFENMGAKLVAEVASKTNDVAGDGTTTATVLAQAMIREG LKNVTAGANPVGVRKGMEQAVAVAIENLKEISKPIEGKESIAQVAAISAADEEVGSLI AEAMERVGNDGVITIEESKGFTTELEVVEGMQFDRGYASPYMVTDSDKMEAVLDNPYI LITDKKITNIQEILPVLEQVVQQGKPLLLIAEDVEGEALATLVVNKLRGTFNAVAVKA PGFGDRRKAMLEDIAVLTGGEVITEDLGLDLKSTQIAQLGRASKVVVTKENTTIVEGA GETDKISARVTQIRAQVEETTSEFDREKLQERLAKLAGGVAVIKVGAATETELKERKL RIEDALNSTRAAVEEGIVSGGGTALVNVYNKVAAVEAEGDAQTGINIVLRALEEPIRQ IAHNAGLEGSVIVERLKNEEIGVGFNAATGEWVNMIEKGIVDPTKVTRSALQNAASVA AMFLTTEAVVADKPEENGGGAGMPDMGGMGGMGGMM*" /label="groEL CDS" gene 611292..612926 /gene="groEL" /locus_tag="BSU_06030" /old_locus_tag="BSU06030" /label="groEL gene" S_feature 612927..613019 /Source="Nicolas_S_feature" /locus_tag="new_651869_651961" /HighExp="HiTm, Etha, dia15, Heat, Diami, dia5, C90, S1, S2, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="Sig-" /TUlongPSig="0.238" /label="S209" downshifts 612976 /Source="Nicolas_upshifts" /id="D292" /incds=0 /nref=228 /ntot=267 /MaxReadThrough="6.24882" /MaxDrop="5.77437" /score="-6.71161833" /energy="-16.3" /TU="U468" /idTUdmin="U466" /TUdmin=2112 /isTUend="FALSE" /label="downshifts" CDS complement(613014..613142) /gene="ydzTc" /locus_tag="BSU_06033" /old_locus_tag="BSU06033" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein; putative integrase (fragment); C-terminal part of YdzT; defective prophage 3" /translation="EAGVGIKEIQQQFGHSDINTTMDIYAHMTANMEKRSPNSLVN*" /label="ydzTc CDS" gene complement(613014..613142) /gene="ydzTc" /locus_tag="BSU_06033" /old_locus_tag="BSU06033" /pseudo /label="ydzTc gene" S_feature 613021..>614247 /Source="Nicolas_S_feature" /locus_tag="new_651963_653431" /HighExp="H2O2, Heat, dia15, Diami, S1, G135, G150, S2, G180, dia5" /AntisenseName="ydzT" /AntisenseCor="-2.9485116084752801E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="0.23100000000000001" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="Sig-" /TUlongPSig="0.238" /label="S210" CDS complement(613145..613303) /gene="ydzT" /locus_tag="BSU_06034" /old_locus_tag="BSU06034" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein; putative integrase (fragment); internal part of YdzT" /db_xref="PSEUDO:CAX52563.1" /translation="MIYQDSSFIFEREDGHPQLRKVIETRLKRLLKKAGIKRMSPPTL LGIPIPPY*" /label="ydzT CDS" gene complement(613145..613303) /gene="ydzT" /locus_tag="BSU_06034" /old_locus_tag="BSU06034" /pseudo /label="ydzT gene" CDS complement(613348..613476) /gene="ydzT" /locus_tag="BSU_06036" /old_locus_tag="BSU06036" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein; putative integrase (fragment); internal part of YdzT" /db_xref="PSEUDO:CAX52564.1" /translation="MISQVTKTLYTPNNQIEKYQLLTPKTTGSVDIVRIDETMSIY*" /label="ydzT CDS" gene complement(613348..613476) /gene="ydzT" /locus_tag="BSU_06036" /old_locus_tag="BSU06036" /pseudo /label="ydzT gene" CDS complement(613569..613778) /gene="ydzT" /locus_tag="BSU_06037" /old_locus_tag="BSU06037" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; Product type e : enzyme" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein; putative integrase (fragment); internal part of YdzT" /db_xref="PSEUDO:CAX52565.1" /translation="MYEDRTLELNEQYSHNCLGGIHACGRMIFRKAKTQGIIKMNPTG DFQLPKKQQSIGKRGADTFSKARSI*" /label="ydzT CDS" gene complement(613569..613778) /gene="ydzT" /locus_tag="BSU_06037" /old_locus_tag="BSU06037" /pseudo /label="ydzT gene" CDS complement(613771..614076) /gene="ydzTn" /locus_tag="BSU_06038" /old_locus_tag="BSU06038" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein; putative integrase (fragment); N-terminal part of YdzT; defective prophage 3" /db_xref="PSEUDO:CAX52566.1" /translation="MELSYLLGIDPLTKKRLEISKGRFKTKKEAPVAARHVELQNDNG TFIKESDMPFKTFAKGWLKIYNRSGVKISSVRASEKKMMHFIAVLGQYPISKTQKNV* " /label="ydzTn CDS" gene complement(613771..614076) /gene="ydzTn" /locus_tag="BSU_06038" /old_locus_tag="BSU06038" /pseudo /label="ydzTn gene" SCAR join(614247,614254) /created_by="AR/SM" /note="deletion occured in betwen marked nucleotides" /label="Delta6_1" N_region 614248..614253 /note="KpnI site (GGTACC)" /created_by="User" /label="Delta6_1" CDS complement(614352..616841) /gene="gutR" /locus_tag="BSU_06140" /old_locus_tag="BSU06140" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11118449, 11390381, 12897001" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11118449, 11390381, 12897001; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of the glucitol operon" /protein_id="NP_388495.1" /db_xref="EnsemblGenomes-Gn:BSU06140" /db_xref="EnsemblGenomes-Tr:CAB12433" /db_xref="GOA:P39143" /db_xref="InterPro:IPR002182" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="InterPro:IPR024123" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10178" /db_xref="UniProtKB/Swiss-Prot:P39143" /translation="MAELENRKQFAQMLAPGVKTLKLHPDYKVRRKKNEKTGQSYIDK IALQLGVSPNTIKSWIGQMGANYIPGRIDDGKLFGMIWIILEKTDLDIEWLTDLLEAT TIPVIKPALPVWAASCLKKAKILRKDGLFGAPSEGEIENVVKRLFHDRPGQETNALTE QPITHNLPSRWSGRFIGRSFDMEAIRQWMLSPSPVCLITGWAGMGKTTIALEAAYSCV DDTSVWPAFNSIIWVSADWKGLSFSDFLNTIAYQLGRKEQIDKSINVKRFVVRNALAN YTREKPILLIVDSIDTAERDIHEFITSLPQGVKVLLTARENVKQTYRESFGEMTAIQL SGLDQTDAHEFFQQEVHHCLQTCNLPRKREKLEQLLHLSSDLKNEFISATAGNPKAMA LSIAYMSDDDIPAQQLIHELGKAGYSLLELFEFLFGRTWDRCNEDTRKLWQTLCFFSK PPDEKSLAAAAGLDARRFHYAMEQMRSYALIQPERSQGRTQYLAHQTVVAYGEQHLSE QHEYEKEARNRWAHYYIDYAETHLKREQPNSIYWSYLLGRNLDQMKQEWPNILKVIQW ASETEQKEILIELITRISHFLSRINLPLRIEYGRKAADAAHHLGQHTREAYFRIDTSG WALMEVNDLDGALQQIEAGLKILEQSDAHDAYDLKVWGHALKARLFLKDGQQEKAETI LNEIENQPISPTIQHRVLLVRGDLSFARGYHVEAIQLYEAANEISSTYGGEKTIEAYF NLGVAYVKCDQFEKAEEAFEQMLYDKHNANQVELIYYHYGMAQLLYRKGEKTKAVESN QKAIRLIDSWEPAIGIRGEVERLARATKENE*" /label="gutR CDS" gene complement(614352..616841) /gene="gutR" /locus_tag="BSU_06140" /old_locus_tag="BSU06140" /label="gutR gene" downshifts complement(614374) /Source="Nicolas_upshifts" /id="D298" /incds=0 /nref=56 /ntot=209 /MaxReadThrough="0.69715" /MaxDrop="4.256" /score="0.285109352" /energy="-13.9" /TU="NA" /idTUdmin="U474" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(616855..616874) /Source="Nicolas_upshift_promotors" /id="U474" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.573426573426573" /psig="0.995004995004995" /xcortree=2305 /SigmaFactorBS="ctttcctgctgtataaaaggacagcggcactgtacttttatt ttttCATATACAaaaaacgctggatTGATAAAATAGTACTAATAGgaggtgcaggctt a" /listShort="gutR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(616881) /Source="Nicolas_upshifts" /id="U474" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.573426573426573" /psig="0.995004995004995" /xcortree=2305 /SigmaFactorBS="ctttcctgctgtataaaaggacagcggcactgtacttttatt ttttCATATACAaaaaacgctggatTGATAAAATAGTACTAATAGgaggtgcaggctt a" /listShort="gutR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(616888..616895) /Source="Nicolas_upshift_promotors" /id="U474" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.573426573426573" /psig="0.995004995004995" /xcortree=2305 /SigmaFactorBS="ctttcctgctgtataaaaggacagcggcactgtacttttatt ttttCATATACAaaaaacgctggatTGATAAAATAGTACTAATAGgaggtgcaggctt a" /listShort="gutR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 616944..616945 /Source="Nicolas_upshift_promotors" /id="U475" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.481518481518482" /psig="0.848151848151848" /xcortree=335 /SigmaFactorBS="aataaaagtacagtgccgctgtccttttatacagcaggaaag gcTGttgaacgtgttaaaaAGCAGATAAAATGGGGGCAGtaacagagaaaacaaaaat g" /listShort="S220, gutB, gutP, ydjE" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 616960..617042 /Source="Nicolas_S_feature" /locus_tag="new_667383_667465" /HighExp="Lbstat, BI, M40t90, Mt0, M0t90, dia5, dia0, Lbexp, Lbtran, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.848" /TUlongSig="NA" /TUlongPSig="NA" /label="S220" upshifts 616960 /Source="Nicolas_upshifts" /id="U475" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.481518481518482" /psig="0.848151848151848" /xcortree=335 /SigmaFactorBS="aataaaagtacagtgccgctgtccttttatacagcaggaaag gcTGttgaacgtgttaaaaAGCAGATAAAATGGGGGCAGtaacagagaaaacaaaaat g" /listShort="S220, gutB, gutP, ydjE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 616961..616980 /Source="Nicolas_upshift_promotors" /id="U475" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.481518481518482" /psig="0.848151848151848" /xcortree=335 /SigmaFactorBS="aataaaagtacagtgccgctgtccttttatacagcaggaaag gcTGttgaacgtgttaaaaAGCAGATAAAATGGGGGCAGtaacagagaaaacaaaaat g" /listShort="S220, gutB, gutP, ydjE" /GFF_Attribute="listLong" /label="promotor_-10" CDS 617043..618104 /gene="gutB" /locus_tag="BSU_06150" /old_locus_tag="BSU06150" /EC_number="1.1.1.14" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1460002, 8195086, 8195087, 12897001, 19784641" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1460002, 8195086, 8195087, 12897001, 19784641; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucitol (sorbitol) dehydrogenase" /protein_id="NP_388496.1" /db_xref="EnsemblGenomes-Gn:BSU06150" /db_xref="EnsemblGenomes-Tr:CAB12434" /db_xref="GOA:Q06004" /db_xref="InterPro:IPR002328" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10177" /db_xref="UniProtKB/Swiss-Prot:Q06004" /translation="MTHTVPQNMKAAVMHNTREIKIETLPVPDINHDEVLIKVMAVGI CGSDLHYYTNGRIGNYVVEKPFILGHECAGEIAAVGSSVDQFKVGDRVAVEPGVTCGR CEACKEGRYNLCPDVQFLATPPVDGAFVQYIKMRQDFVFLIPDSLSYEEAALIEPFSV GIHAAARTKLQPGSTIAIMGMGPVGLMAVAAAKAFGAGTIIVTDLEPLRLEAAKKMGA THIINIREQDALEEIKTITNDRGVDVAWETAGNPAALQSALASVRRGGKLAIVGLPSQ NEIPLNVPFIADNEIDIYGIFRYANTYPKGIEFLASGIVDTKHLVTDQYSLEQTQDAM ERALQFKNECLKVMVYPNR*" /label="gutB CDS" gene 617043..618104 /gene="gutB" /locus_tag="BSU_06150" /old_locus_tag="BSU06150" /label="gutB gene" CDS 618178..619569 /gene="gutP" /locus_tag="BSU_06160" /old_locus_tag="BSU06160" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12897001, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="H+-glucitol symporter; prophage region 3" /protein_id="NP_388497.1" /db_xref="EnsemblGenomes-Gn:BSU06160" /db_xref="EnsemblGenomes-Tr:CAB12435" /db_xref="GOA:O34368" /db_xref="InterPro:IPR001927" /db_xref="InterPro:IPR018043" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12795" /db_xref="UniProtKB/Swiss-Prot:O34368" /translation="MIGTEKVTALKAKHQSKSSTGLSWFERIGYGFGDMSYNIIFQFV NAYLLFYYTDVGGIQPAVIATLFLVVRVLDAIFDPIMGLILDKTNTRWGKARPYLLWV AFPFALFTFLCFTTPHFGETGNMVYAYVTYILLGMSFSMQTIPVNSLTGRMTNSVEER TVLTTTRMILVYIGILLSISCATPLATAIGGEDQAFGFQMTALIYAAVSIVLNLFSFF TVRERIQPKKRKKQGIKKTLSVLFKNKPLLMLISSFLAFAIGFNIKLSTMVYYFTYNV NHKEFVFMGTVLFFGAALISNLFIPFFSEKWGRKQVMIITAALSLISYAGLHFTPYSS IPLIFIWLFASGFFTTPLNTLAWGMVADCVDYAEWKTGIRADGVVISSMSFINKLGVA LAGSFSAIYLGIAGYVANTDQTVASLNAIKNMNALIPGFFILLSIILIAFYPLTEKRY KHIISELEQRSAR*" /label="gutP CDS" gene 618178..619569 /gene="gutP" /locus_tag="BSU_06160" /old_locus_tag="BSU06160" /label="gutP gene" promotor_-35 619596..619603 /Source="Nicolas_upshift_promotors" /id="U476" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.871128871128871" /psig="0.997002997002997" /xcortree=489 /SigmaFactorBS="cgagataaatagatgtaaaatttttaatattcaaTGTTGTAT ttatggcaaaaagTAATATACTGAGACTGTAATctagactttataaatgagtgtgata a" /listShort="ydjE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 619617..619636 /Source="Nicolas_upshift_promotors" /id="U476" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.871128871128871" /psig="0.997002997002997" /xcortree=489 /SigmaFactorBS="cgagataaatagatgtaaaatttttaatattcaaTGTTGTAT ttatggcaaaaagTAATATACTGAGACTGTAATctagactttataaatgagtgtgata a" /listShort="ydjE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 619622 /Source="Nicolas_upshifts" /id="U476" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.871128871128871" /psig="0.997002997002997" /xcortree=489 /SigmaFactorBS="cgagataaatagatgtaaaatttttaatattcaaTGTTGTAT ttatggcaaaaagTAATATACTGAGACTGTAATctagactttataaatgagtgtgata a" /listShort="ydjE" /GFF_Attribute="listLong" /label="upshifts" CDS 619664..620626 /gene="ydjE" /locus_tag="BSU_06170" /old_locus_tag="BSU06170" /EC_number="2.7.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26483775, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sugar kinase (ribokinase family); prophage region 3" /protein_id="NP_388498.1" /db_xref="EnsemblGenomes-Gn:BSU06170" /db_xref="EnsemblGenomes-Tr:CAB12436" /db_xref="GOA:O34768" /db_xref="InterPro:IPR002173" /db_xref="InterPro:IPR011611" /db_xref="InterPro:IPR029056" /db_xref="SubtiList:BG12796" /db_xref="UniProtKB/Swiss-Prot:O34768" /translation="MRSHSVVCIGELLIDFFCTDVDVDLMEGRQFLKSAGGAPANVSA AIAKLGGDAAFSGKVGKDPFGYFLKRTLDAVHVDTSMLVMDEKAPTTLAFVSLKQNGE RDFVFNRGADALFTLEDIDQEKLNEAKILHFGSATALLSDPFCSAYLRLMSIAKDNGQ FISFDPNYREDLWRGRVSEFVSVAKKAIAVSDFVKVSDEELEIISGVKDHEKGVAILH EIGANIVAVTLGKSGTLLSNGKDREIIPSIPVTSIDSTGAGDAFVGAALYQLANTDQI QSVDADFVKLREIVAFANKVGALVCTKIGAIDALPSLDEIGVSL*" /label="ydjE CDS" gene 619664..620626 /gene="ydjE" /locus_tag="BSU_06170" /old_locus_tag="BSU06170" /label="ydjE gene" downshifts 620611 /Source="Nicolas_upshifts" /id="D299" /incds=0 /nref=86 /ntot=213 /MaxReadThrough="2.99546" /MaxDrop="4.52045" /score="16.4550614" /energy="-14" /TU="NA" /idTUdmin="U475" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 620751..620760 /Source="Nicolas_upshift_promotors" /id="U477" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1663 /SigmaFactorBS="agttgtatattttttgtttgaaatgtcattttttattaaaaa agTGAAACTTTTaacgataataaaTAGTATATGTAACAAGggttaccgaattagcttt a" /listShort="pspA, S221, ydjG, ydjH, ydjI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 620767 /Source="Nicolas_upshifts" /id="U477" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1663 /SigmaFactorBS="agttgtatattttttgtttgaaatgtcattttttattaaaaa agTGAAACTTTTaacgataataaaTAGTATATGTAACAAGggttaccgaattagcttt a" /listShort="pspA, S221, ydjG, ydjH, ydjI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 620773..620788 /Source="Nicolas_upshift_promotors" /id="U477" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1663 /SigmaFactorBS="agttgtatattttttgtttgaaatgtcattttttattaaaaa agTGAAACTTTTaacgataataaaTAGTATATGTAACAAGggttaccgaattagcttt a" /listShort="pspA, S221, ydjG, ydjH, ydjI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 620822..621505 /gene="pspA" /locus_tag="BSU_06180" /old_locus_tag="BSU06180" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11454200" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11454200; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="phage shock protein A homolog regulator; prophage region 3" /protein_id="NP_388499.1" /db_xref="EnsemblGenomes-Gn:BSU06180" /db_xref="EnsemblGenomes-Tr:CAB12437" /db_xref="GOA:P54617" /db_xref="InterPro:IPR007157" /db_xref="SubtiList:BG12797" /db_xref="UniProtKB/Swiss-Prot:P54617" /translation="MSIIGRFKDIMSANINALLDKAENPEKMVDQYLRNMNSDLAKVK AETAAVMAEEQRAKREYHECQADMEKMESYAMKALQAGNESDARKFLERKTSLESKLS ELQAANQIAATNAAQMRKMHDKLVSDIGELEARKNMIKAKWAVAKTQERMNKLGASVS STSQSMSAFGRMEDKVNKALDQANAMAELNSAPQDDMADLSAKYDTGGSSQVDDELAA LKAKMMLDK*" /label="pspA CDS" gene 620822..621505 /gene="pspA" /locus_tag="BSU_06180" /old_locus_tag="BSU06180" /label="pspA gene" S_feature 621506..621570 /Source="Nicolas_S_feature" /locus_tag="new_671929_671993" /HighExp="Salt, S0, aero, T-0.40H, T-1.40H, SMMPr, T-1.10H, T0.0H, Cold, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S221" CDS 621571..622596 /gene="ydjG" /locus_tag="BSU_06190" /old_locus_tag="BSU06190" /function="16.5: Explore" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage replication protein; prophage region 3" /protein_id="NP_388500.1" /db_xref="EnsemblGenomes-Gn:BSU06190" /db_xref="EnsemblGenomes-Tr:CAB12438" /db_xref="GOA:O34434" /db_xref="InterPro:IPR013137" /db_xref="SubtiList:BG12798" /db_xref="UniProtKB/Swiss-Prot:O34434" /translation="MIISYKCPNCGSDMAFDSETGSLSCSSCGRQDNIESLPKENIAA RFSDDEAKEYQCKNCGAVLITEAETTATTCSFCGGAAILADRLSGHLAPAKVIPFTIS KQEAEQAFRKWCKKGLLTPRGFMSADRIKSITGMYIPFWMFDLNSEVQVRANCTRVHQ YEEGDYICTETEHFEAFRDINLDYLKIPVDASEKMKDELMDKLEPYSYEELKDFQTAY LAGYIAEKYNYTDEELFPRAKEKISSYIDSYIHSTFSGYTSVNVRDKHIHTKNVNSFY VLLPVWMVSYDYERAEHIFAMNGQTGKVVGKPPISRGKVAAWFSGIAGGTFLALKLVS LMMGGGF*" /label="ydjG CDS" gene 621571..622596 /gene="ydjG" /locus_tag="BSU_06190" /old_locus_tag="BSU06190" /label="ydjG gene" CDS 622596..623360 /gene="ydjH" /locus_tag="BSU_06200" /old_locus_tag="BSU06200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; prophage region 3" /protein_id="NP_388501.1" /db_xref="EnsemblGenomes-Gn:BSU06200" /db_xref="EnsemblGenomes-Tr:CAB12439" /db_xref="GOA:O35004" /db_xref="InterPro:IPR007621" /db_xref="SubtiList:BG12799" /db_xref="UniProtKB/Swiss-Prot:O35004" /translation="MRGFFGKAIFVVLAVFIMMPLLGIEAVRASELQQHVYDRAHLLS KAEIGKLESLSAKLGAKRDTDFIIITTKSTNGEDIADYTGDFYDRYGKGSTAILTIDM TNREVFIAGFKKAEQYLDNSRLNSIRNTISSDLSNENYFEAFETYIQLSYKDMGIKPG VNPDNIFFTWWFQLIAAIAVGGIAVSIMLYHAGGKVTVNGSTYMDQRTSDVIDQYDTY IRTTVTRERKPSDKDSGSDGGVTKGGTSYSGSRGSF*" /label="ydjH CDS" gene 622596..623360 /gene="ydjH" /locus_tag="BSU_06200" /old_locus_tag="BSU06200" /label="ydjH gene" CDS 623391..624362 /gene="ydjI" /locus_tag="BSU_06210" /old_locus_tag="BSU06210" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage protein" /protein_id="NP_388502.1" /db_xref="EnsemblGenomes-Gn:BSU06210" /db_xref="EnsemblGenomes-Tr:CAB12440" /db_xref="InterPro:IPR033880" /db_xref="InterPro:IPR036013" /db_xref="SubtiList:BG12800" /db_xref="UniProtKB/Swiss-Prot:O34789" /translation="MSFFRNQLANVVEWEEFRDDMIFYKWNNREIKKGSRLIIRPGQD AVFLNNGRVEGVFQDDGDYDIESEIIPFLSTLKGFKFGFNSGMRAEVLFVNTKEFTVR WGTKQAINIPAAGMPGGMPIRANGTFNFKVQDYISLIDKIAGVKDQYFVEDIKTRIIS ILDQLLMKWITREGKDMFNLQANAFDIAKGIQEDLDMQLISDGMTVTGFQIMSFNYPQ EVQDMITKNASYGMVGDVNRYQQISMTDGMASGKMSGSGAASDMAGMMMGMNMANQMM NQMNQNQQAQSSGPQSTGSGSKPNFCPNCGTKTGEANFCPNCGQKLV*" /label="ydjI CDS" gene 623391..624362 /gene="ydjI" /locus_tag="BSU_06210" /old_locus_tag="BSU06210" /label="ydjI gene" downshifts 624352 /Source="Nicolas_upshifts" /id="D300" /incds=0 /nref=180 /ntot=247 /MaxReadThrough="2.71622" /MaxDrop="5.81579" /score="16.72046" /energy="-11.1" /TU="U477" /idTUdmin="U477" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" downshifts 624396 /Source="Nicolas_upshifts" /id="D301" /incds=0 /nref=1 /ntot=2 /MaxReadThrough="2.13813" /MaxDrop="3.25329" /score="16.72046" /energy="-11.1" /TU="NA" /idTUdmin="U477" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(624409..625434) /gene="ydjJ" /locus_tag="BSU_06220" /old_locus_tag="BSU06220" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative membrane associated potassium channel; prophage region 3" /protein_id="NP_388503.1" /db_xref="EnsemblGenomes-Gn:BSU06220" /db_xref="EnsemblGenomes-Tr:CAB12441" /db_xref="GOA:O34733" /db_xref="InterPro:IPR013099" /db_xref="SubtiList:BG12801" /db_xref="UniProtKB/Swiss-Prot:O34733" /translation="MNEGYIIAGLLLLTAGMIDFLWTTLWLESGAGPITRCLSAWLWK GCRKISGDHAKVLSMAGPLLLCLTLVIWISLFWSGWVLIYSSDPHSLMETQSKEPASW SDRIYFSGYVMFTLGNGDLAPNGGLWKLVTIIETAQGLLTITFSVTYLISVLSAVNQK RSFAQSVLSLGHDGTEIVHNAWNGKDFHDIDFLLVAASSELGKLTAQHNAFPILHFYH STQHQESSIIAVAVLDEALTIFKYGIPEQYQPNQLHIKEARSSIKNYLDTVHTAYIHP AEQAPPEPDISKLQQSGIPALSKQTFQIAVNSIKERRQLLLGIIQAGARKWPVQEQAI GNAYSPK*" /label="ydjJ CDS" gene complement(624409..625434) /gene="ydjJ" /locus_tag="BSU_06220" /old_locus_tag="BSU06220" /label="ydjJ gene" promotor_-10 complement(625466..625485) /Source="Nicolas_upshift_promotors" /id="U478" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=251 /SigmaFactorBS="ccacctatttttctctgtaaaatcaaacattcgttcaatTGT TTCAgactcaggataaaAGGAAATAGAGAAGAAAATAaaagaaggctgacttaaggga g" /listShort="ydjJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(625484) /Source="Nicolas_upshifts" /id="U478" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=251 /SigmaFactorBS="ccacctatttttctctgtaaaatcaaacattcgttcaatTGT TTCAgactcaggataaaAGGAAATAGAGAAGAAAATAaaagaaggctgacttaaggga g" /listShort="ydjJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(625499..625505) /Source="Nicolas_upshift_promotors" /id="U478" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=251 /SigmaFactorBS="ccacctatttttctctgtaaaatcaaacattcgttcaatTGT TTCAgactcaggataaaAGGAAATAGAGAAGAAAATAaaagaaggctgacttaaggga g" /listShort="ydjJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 625694..625701 /Source="Nicolas_upshift_promotors" /id="U479" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=323 /SigmaFactorBS="tgattttccttttatagagtaaaaaattttcagaaatttaTA TTGACTgaaagcgtttttatAATTATGATAATATCAGATAtaacaaaaatgtcactat a" /listShort="S222, iolT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 625714 /Source="Nicolas_upshifts" /id="U479" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=323 /SigmaFactorBS="tgattttccttttatagagtaaaaaattttcagaaatttaTA TTGACTgaaagcgtttttatAATTATGATAATATCAGATAtaacaaaaatgtcactat a" /listShort="S222, iolT" /GFF_Attribute="listLong" /label="upshifts" S_feature 625716..626018 /Source="Nicolas_S_feature" /locus_tag="new_676139_676441" /HighExp="M0t90, M40t90, Lbtran, T0.30H, BI, T1.0H, M9-stat, S1, T1.30H, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.28450700000000001" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S222" promotor_-10 625716..625735 /Source="Nicolas_upshift_promotors" /id="U479" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=323 /SigmaFactorBS="tgattttccttttatagagtaaaaaattttcagaaatttaTA TTGACTgaaagcgtttttatAATTATGATAATATCAGATAtaacaaaaatgtcactat a" /listShort="S222, iolT" /GFF_Attribute="listLong" /label="promotor_-10" CDS 626019..627440 /gene="iolT" /locus_tag="BSU_06230" /old_locus_tag="BSU06230" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11807058, 15849754, 16850406, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11807058, 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="myo-inositol transporter" /protein_id="NP_388504.1" /db_xref="EnsemblGenomes-Gn:BSU06230" /db_xref="EnsemblGenomes-Tr:CAB12442" /db_xref="GOA:O34718" /db_xref="InterPro:IPR003663" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12802" /db_xref="UniProtKB/Swiss-Prot:O34718" /translation="MNKQGNQMSFLRTIILVSTFGGLLFGYDTGVLNGALPYMGEPDQ LNLNAFTEGLVTSSLLFGAALGAVFGGRMSDFNGRRKNILFLAVIFFISTIGCTFAPN VTVMIISRFVLGIAVGGASVTVPAYLAEMSPVESRGRMVTQNELMIVSGQLLAFVFNA ILGTTMGDNSHVWRFMLVIASLPALFLFFGMIRMPESPRWLVSKGRKEDALRVLKKIR DEKRAAAELQEIEFAFKKEDQLEKATFKDLSVPWVRRIVFIGLGIAIVQQITGVNSIM YYGTEILRNSGFQTEAALIGNIANGVISVLATFVGIWLLGRVGRRPMLMTGLIGTTTA LLLIGIFSLVLEGSPALPYVVLSLTVTFLAFQQGAISPVTWLMLSEIFPLRLRGLGMG VTVFCLWMVNFAVSFTFPILLAAIGLSTTFFIFVGLGICSVLFVKRFLPETKGLSLEQ LEENFRAYDHSGAKKDSGAEVIG*" /label="iolT CDS" gene 626019..627440 /gene="iolT" /locus_tag="BSU_06230" /old_locus_tag="BSU06230" /label="iolT gene" downshifts 627432 /Source="Nicolas_upshifts" /id="D302" /incds=0 /nref=11 /ntot=24 /MaxReadThrough="2.82455" /MaxDrop="8.02371" /score="11.3880907" /energy="-11.2" /TU="NA" /idTUdmin="U479" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(627488) /Source="Nicolas_upshifts" /id="D303" /incds=0 /nref=242 /ntot=272 /MaxReadThrough="1.00274" /MaxDrop="9.32541" /score="13.6781112" /energy="-11.2" /TU="NA" /idTUdmin="U482" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(627488..628528) /gene="bdhA" /locus_tag="BSU_06240" /old_locus_tag="BSU06240" /EC_number="1.1.1.4" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12469342, 18820069, 24525333, 26428232, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12469342, 18820069, 24525333, 26428232, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetoin reductase/2,3-butanediol dehydrogenase" /protein_id="NP_388505.1" /db_xref="EnsemblGenomes-Gn:BSU06240" /db_xref="EnsemblGenomes-Tr:CAB12443" /db_xref="GOA:O34788" /db_xref="InterPro:IPR002328" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12803" /db_xref="UniProtKB/Swiss-Prot:O34788" /translation="MKAARWHNQKDIRIEHIEEPKTEPGKVKIKVKWCGICGSDLHEY LGGPIFIPVDKPHPLTNETAPVTMGHEFSGEVVEVGEGVENYKVGDRVVVEPIFATHG HQGAYNLDEQMGFLGLAGGGGGFSEYVSVDEELLFKLPDELSYEQGALVEPSAVALYA VRSSKLKAGDKAAVFGCGPIGLLVIEALKAAGATDIYAVELSPERQQKAEELGAIIVD PSKTDDVVAEIAERTGGGVDVAFEVTGVPVVLRQAIQSTTIAGETVIVSIWEKGAEIH PNDIVIKERTVKGIIGYRDIFPAVLSLMKEGYFSADKLVTKKIVLDDLIEEGFGALIK EKSQVKILVRPN*" /label="bdhA CDS" gene complement(627488..628528) /gene="bdhA" /locus_tag="BSU_06240" /old_locus_tag="BSU06240" /label="bdhA gene" promotor_-35 628068..628077 /Source="Nicolas_upshift_promotors" /id="U480" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1246 /SigmaFactorBS="agtttgcttgagcggacagcgtatagagcaactgcaGAAGGT TCAAcgagcgcgccttgTTCATATGATAATTCATCAGgaagtttgaacaaaagctctt c" /listShort="S223" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 628091..628110 /Source="Nicolas_upshift_promotors" /id="U480" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1246 /SigmaFactorBS="agtttgcttgagcggacagcgtatagagcaactgcaGAAGGT TCAAcgagcgcgccttgTTCATATGATAATTCATCAGgaagtttgaacaaaagctctt c" /listShort="S223" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 628092..628627 /Source="Nicolas_S_feature" /locus_tag="new_678515_679050" /HighExp="C30, Gly, S6, C90, S8, BT, S7, Sw, Fru, Lbstat" /AntisenseName="bdhA" /AntisenseCor="-0.174163895138467" /AntisenseRegPval="-2.4" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S223" upshifts 628092 /Source="Nicolas_upshifts" /id="U480" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1246 /SigmaFactorBS="agtttgcttgagcggacagcgtatagagcaactgcaGAAGGT TCAAcgagcgcgccttgTTCATATGATAATTCATCAGgaagtttgaacaaaagctctt c" /listShort="S223" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(628529..628823) /Source="Nicolas_S_feature" /locus_tag="new_678952_679246_c" /HighExp="Lbtran, BI, T1.0H, M40t90, LBGstat, LoTm, T0.30H, LPhT, Lbstat, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S224" misc_feature 628628..628647 /Source="Nicolas_upshift_promotors" /id="U481" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.866133866133866" /psig="0.994005994005994" /xcortree=1752 /SigmaFactorBS="accggtcaatatgaactgttcacaaaatcgccatttttaaaa ccaaaaaagaaatgaaaTTTTTATATAATATAATCTAcgtttttttgaaaaaaagaaa c" /listShort="S225" /listLong="ydjM, ydjN" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 628629..628926 /Source="Nicolas_S_feature" /locus_tag="new_679052_679349" /HighExp="G180, Paraq, Oxctl, H2O2, G135, G150, MG 5, C30, UNK1, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S225" upshifts 628629 /Source="Nicolas_upshifts" /id="U481" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.866133866133866" /psig="0.994005994005994" /xcortree=1752 /SigmaFactorBS="accggtcaatatgaactgttcacaaaatcgccatttttaaaa ccaaaaaagaaatgaaaTTTTTATATAATATAATCTAcgtttttttgaaaaaaagaaa c" /listShort="S225" /listLong="ydjM, ydjN" /label="upshifts" misc_feature complement(628818..628832) /Source="Nicolas_upshift_promotors" /id="U482" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.598401598401598" /psig="0.99000999000999" /xcortree=3201 /SigmaFactorBS="tacaaagtcaaaaaagttacctctgctaaaataaaccatgga agattatccTATTATAATAGCAGTattagagttataattattgatagagtagttgtcg c" /listShort="S224, bdhA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(628823) /Source="Nicolas_upshifts" /id="U482" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.598401598401598" /psig="0.99000999000999" /xcortree=3201 /SigmaFactorBS="tacaaagtcaaaaaagttacctctgctaaaataaaccatgga agattatccTATTATAATAGCAGTattagagttataattattgatagagtagttgtcg c" /listShort="S224, bdhA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 628925..628944 /Source="Nicolas_upshift_promotors" /id="U483" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.462537462537463" /psig="0.998001998001998" /xcortree=3034 /SigmaFactorBS="cttttttgactttgtaacattactgtaaggatattgaaAtaa aaaatagctggttgaTCGTGTATAATCTTCCTAGAtgttaacaaacagggggacgaaa t" /listShort="ydjM, ydjN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 628928 /Source="Nicolas_upshifts" /id="U483" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.462537462537463" /psig="0.998001998001998" /xcortree=3034 /SigmaFactorBS="cttttttgactttgtaacattactgtaaggatattgaaAtaa aaaatagctggttgaTCGTGTATAATCTTCCTAGAtgttaacaaacagggggacgaaa t" /listShort="ydjM, ydjN" /GFF_Attribute="listLong" /label="upshifts" CDS 628967..629338 /gene="walM" /locus_tag="BSU_06250" /old_locus_tag="BSU06250" /experiment="publication(s) with functional evidences, PMID:17581128, 20487291" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17581128, 20487291; Product type f: factor" /codon_start=1 /transl_table=11 /product="protein involved in cell wall metabolism" /protein_id="NP_388506.1" /db_xref="EnsemblGenomes-Gn:BSU06250" /db_xref="EnsemblGenomes-Tr:CAB12444" /db_xref="InterPro:IPR009009" /db_xref="InterPro:IPR036908" /db_xref="SubtiList:BG11036" /db_xref="UniProtKB/Swiss-Prot:P40775" /translation="MLKKVILAAFILVGSTLGAFSFSSDASAKHVNGNITWYNGVGKK GSSGKKLGHWDCATKIGFDVPRNGTKIRAYAKAKPKKVITVYKNDVGRMPNAVLDVSP KAFKALGYPLSKGKVAGHYSY*" /label="walM CDS" gene 628967..629338 /gene="walM" /locus_tag="BSU_06250" /old_locus_tag="BSU06250" /label="walM gene" downshifts 629324 /Source="Nicolas_upshifts" /id="D304" /incds=0 /nref=5 /ntot=52 /MaxReadThrough="5.74148" /MaxDrop="2.8439" /score="-1.55787542" /energy="-7.4" /TU="U483" /idTUdmin="U481" /TUdmin=418 /isTUend="FALSE" /label="downshifts" CDS 629404..630450 /gene="ydjN" /locus_tag="BSU_06260" /old_locus_tag="BSU06260" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="NP_388507.1" /db_xref="EnsemblGenomes-Gn:BSU06260" /db_xref="EnsemblGenomes-Tr:CAB12445" /db_xref="InterPro:IPR011659" /db_xref="InterPro:IPR015943" /db_xref="SubtiList:BG12804" /db_xref="UniProtKB/Swiss-Prot:O34353" /translation="MKKRIILLLAVIIAAAAAGVAFYVAKDKGHEKAADVSVNTESGD ELLVSITDTDLLTKYYENDKVIHEEKLTSYPAFALDQKQQVLYYTGNNEQNEMRLFKL DLKSHKKTMLYKGAESADSLFLSKDRSTIYFRLGKADESNFRIAAFDLKTKKYKNLYP AANDQDDTVSSFFYNQKNDSFALLHYSVEEDYKKTDEANEKGIDPEPTTIHFAEGRQN KFNELKSLNQFISDIAVSDDDKRILFTSYTQKGTEQTASIQMLNADTKKYESIISNQK SFKLLIDAQPQFSKDGKNIYFLAEAKGAKKLKDETGREAKVRTIYSYSLENKTFKKVW ENPNGIINSFFVIN*" /label="ydjN CDS" gene 629404..630450 /gene="ydjN" /locus_tag="BSU_06260" /old_locus_tag="BSU06260" /label="ydjN gene" downshifts 630424 /Source="Nicolas_upshifts" /id="D305" /incds=0 /nref=41 /ntot=177 /MaxReadThrough="1.73572" /MaxDrop="4.49184" /score="21.8200083" /energy="-13.9" /TU="NA" /idTUdmin="U483" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(630484..630642) /gene="ydzJ" /locus_tag="BSU_06269" /old_locus_tag="BSU06269" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097689.1" /db_xref="EnsemblGenomes-Gn:BSU06269" /db_xref="EnsemblGenomes-Tr:CAX52576" /db_xref="GOA:O24817" /db_xref="UniProtKB/Swiss-Prot:O24817" /translation="MISNQQQKDLKKRAAFKKLNVAMNSYVELLFLSVPLIHIFKWLG SLALHLIH*" /label="ydzJ CDS" gene complement(630484..630642) /gene="ydzJ" /locus_tag="BSU_06269" /old_locus_tag="BSU06269" /label="ydzJ gene" downshifts complement(630500) /Source="Nicolas_upshifts" /id="D306" /incds=0 /nref=23 /ntot=155 /MaxReadThrough="0.7906" /MaxDrop="3.61386" /score="9.10659473" /energy="-10.1" /TU="NA" /idTUdmin="U487" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(630699..630831) /Source="Nicolas_S_feature" /locus_tag="new_681122_681254_c" /HighExp="LoTm, S8, S5, S6, S4, B36, S7, Cold, B60, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF, SigWXY" /TUshortPSig="0.994, 1, 1" /TUlongSig="SigK" /TUlongPSig="0.994" /label="S226" downshifts complement(630742) /Source="Nicolas_upshifts" /id="D307" /incds=0 /nref=57 /ntot=272 /MaxReadThrough="3.03092" /MaxDrop="6.46708" /score="5.41743429" /energy="-8.4" /TU="U484,U486,U487" /idTUdmin="U484" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(630832..631041) /gene="ydjO" /locus_tag="BSU_06270" /old_locus_tag="BSU06270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 28197687" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388508.1" /db_xref="EnsemblGenomes-Gn:BSU06270" /db_xref="EnsemblGenomes-Tr:CAB12446" /db_xref="InterPro:IPR025916" /db_xref="SubtiList:BG12805" /db_xref="UniProtKB/Swiss-Prot:O34759" /translation="MSYYNKRNQEPLPKEDVSTWECTKEDCNGWTRKNFASSDTPLCP LCGSKMVDGIRSLVNLQNNSQTKTS*" /label="ydjO CDS" gene complement(630832..631041) /gene="ydjO" /locus_tag="BSU_06270" /old_locus_tag="BSU06270" /label="ydjO gene" promotor_-10 complement(631074..631093) /Source="Nicolas_upshift_promotors" /id="U484" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.66033966033966" /psig="0.994005994005994" /xcortree=586 /SigmaFactorBS="tggggttattggaaagtcataaagaaaaaggaattAggagat tagggaaaagTATGAGACAATAGGAAATGTgcagtaaaatacatgagggaagaagtga c" /listShort="ydjO, S226" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(631085) /Source="Nicolas_upshifts" /id="U484" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.66033966033966" /psig="0.994005994005994" /xcortree=586 /SigmaFactorBS="tggggttattggaaagtcataaagaaaaaggaattAggagat tagggaaaagTATGAGACAATAGGAAATGTgcagtaaaatacatgagggaagaagtga c" /listShort="ydjO, S226" /GFF_Attribute="listLong" /label="upshifts" CDS complement(631124..631939) /gene="ydjP" /locus_tag="BSU_06280" /old_locus_tag="BSU06280" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9987136; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aminoacrylate hydrolase" /protein_id="NP_388509.1" /db_xref="EnsemblGenomes-Gn:BSU06280" /db_xref="EnsemblGenomes-Tr:CAB12447" /db_xref="GOA:O34592" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12806" /db_xref="UniProtKB/Swiss-Prot:O34592" /translation="MPYIILEDQTRLYYETHGSGTPILFIHGVLMSGQFFHKQFSVLS ANYQCIRLDLRGHGESDKVLHGHTISQYARDIREFLNAMELDHVVLAGWSMGAFVVWD YLNQFGNDNIQAAVIIDQSASDYQWEGWEHGPFDFDGLKTAMHAIQTDPLPFYESFIQ NMFAEPPAETETEWMLAEILKQPAAISSTILFNQTAADYRGTLQNINVPALLCFGEDK KFFSTAAGEHLRSNIPNATLVTFPKSSHCPFLEEPDAFNSTLLSFLDGVIGKS*" /label="ydjP CDS" gene complement(631124..631939) /gene="ydjP" /locus_tag="BSU_06280" /old_locus_tag="BSU06280" /label="ydjP gene" promotor_-35 631766..631775 /Source="Nicolas_upshift_promotors" /id="U485" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1434 /SigmaFactorBS="tgggaaatggtgtggccgtgaagcactttgtcagattcGCCG TGTCCTctaagatcaagaCGAATACATTGATAATTGGCagaaagcaccgaaaattgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 631788..631807 /Source="Nicolas_upshift_promotors" /id="U485" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1434 /SigmaFactorBS="tgggaaatggtgtggccgtgaagcactttgtcagattcGCCG TGTCCTctaagatcaagaCGAATACATTGATAATTGGCagaaagcaccgaaaattgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 631788 /Source="Nicolas_upshifts" /id="U485" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1434 /SigmaFactorBS="tgggaaatggtgtggccgtgaagcactttgtcagattcGCCG TGTCCTctaagatcaagaCGAATACATTGATAATTGGCagaaagcaccgaaaattgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(631952..632941) /gene="yeaA" /locus_tag="BSU_06290" /old_locus_tag="BSU06290" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388510.1" /db_xref="EnsemblGenomes-Gn:BSU06290" /db_xref="EnsemblGenomes-Tr:CAB12448" /db_xref="InterPro:IPR025062" /db_xref="SubtiList:BG12210" /db_xref="UniProtKB/Swiss-Prot:O34803" /translation="MLTHDLHEKTKHYISIYAELKTKLKWKVSHDQILMLISSAYIVN KREFDFQRFYDLSSYIKSNIGSFSTLNSHHRFTVASILDIHFQHEAKQTFQTFIDVYN EMVKLGYKRDMFTYLSALILLTGKSETTNQKEQMNMGLAVYQQMKKNHYFLTSTQNVP LAVLLGENGKGLQALQKAETCYQLLAANGFKKGQYLHQVSHILALQSEKEPEMLVSAC KQIYQSITESVKKTKDYHYPDLALLTFLEEPDIKTVLCITDELNQEKAFKWQKEMNFK IAVSLYLSEHMEKNLLMESGLYTAIETVIQAQQAAATAAIISSTAASHTHDGN*" /label="yeaA CDS" gene complement(631952..632941) /gene="yeaA" /locus_tag="BSU_06290" /old_locus_tag="BSU06290" /label="yeaA gene" promotor_-10 complement(632806..632824) /Source="Nicolas_upshift_promotors" /id="U486" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1147 /SigmaFactorBS="aattaaaatggaaagtttcacacgatcagATATTAatgctca tttcttctGCATATATTGTGAATAAAAgagagtttgattttcagcgcttttatgattt g" /listShort="ydjP, ydjO, S226" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(632814) /Source="Nicolas_upshifts" /id="U486" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1147 /SigmaFactorBS="aattaaaatggaaagtttcacacgatcagATATTAatgctca tttcttctGCATATATTGTGAATAAAAgagagtttgattttcagcgcttttatgattt g" /listShort="ydjP, ydjO, S226" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(632840..632845) /Source="Nicolas_upshift_promotors" /id="U486" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1147 /SigmaFactorBS="aattaaaatggaaagtttcacacgatcagATATTAatgctca tttcttctGCATATATTGTGAATAAAAgagagtttgattttcagcgcttttatgattt g" /listShort="ydjP, ydjO, S226" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(632963..632978) /Source="Nicolas_upshift_promotors" /id="U487" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1666 /SigmaFactorBS="aaataacccgacaaacttgcctctagcaggcaagttttttct ttaTGAAACCTTTggccctatttaTCGTATTACGTAAAAAcaacaaaaggagctgctt t" /listShort="yeaA, ydjP, ydjO, S226, ydzJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(632984) /Source="Nicolas_upshifts" /id="U487" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1666 /SigmaFactorBS="aaataacccgacaaacttgcctctagcaggcaagttttttct ttaTGAAACCTTTggccctatttaTCGTATTACGTAAAAAcaacaaaaggagctgctt t" /listShort="yeaA, ydjP, ydjO, S226, ydzJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(632990..632999) /Source="Nicolas_upshift_promotors" /id="U487" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1666 /SigmaFactorBS="aaataacccgacaaacttgcctctagcaggcaagttttttct ttaTGAAACCTTTggccctatttaTCGTATTACGTAAAAAcaacaaaaggagctgctt t" /listShort="yeaA, ydjP, ydjO, S226, ydzJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(633039..634580) /gene="cotA" /locus_tag="BSU_06300" /old_locus_tag="BSU06300" /EC_number="1.3.3.5" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11514528, 12637519, 16391148, 17242517, 18031270, 19933362, 22112278, 25259857, 27050268" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11514528, 12637519, 16391148, 17242517, 18031270, 19933362, 22112278, 25259857, 27050268; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="outer spore coat copper-dependent promiscuous laccase" /protein_id="NP_388511.1" /db_xref="EnsemblGenomes-Gn:BSU06300" /db_xref="EnsemblGenomes-Tr:CAB12449" /db_xref="GOA:P07788" /db_xref="InterPro:IPR001117" /db_xref="InterPro:IPR008972" /db_xref="InterPro:IPR011706" /db_xref="InterPro:IPR011707" /db_xref="PDB:1GSK" /db_xref="PDB:1OF0" /db_xref="PDB:1W6L" /db_xref="PDB:1W6W" /db_xref="PDB:1W8E" /db_xref="PDB:2BHF" /db_xref="PDB:2WSD" /db_xref="PDB:2X87" /db_xref="PDB:2X88" /db_xref="PDB:3ZDW" /db_xref="PDB:4A66" /db_xref="PDB:4A67" /db_xref="PDB:4A68" /db_xref="PDB:4AKO" /db_xref="PDB:4AKP" /db_xref="PDB:4AKQ" /db_xref="PDB:4Q89" /db_xref="PDB:4Q8B" /db_xref="PDB:4YVN" /db_xref="PDB:4YVU" /db_xref="SubtiList:BG10490" /db_xref="UniProtKB/Swiss-Prot:P07788" /translation="MTLEKFVDALPIPDTLKPVQQSKEKTYYEVTMEECTHQLHRDLP PTRLWGYNGLFPGPTIEVKRNENVYVKWMNNLPSTHFLPIDHTIHHSDSQHEEPEVKT VVHLHGGVTPDDSDGYPEAWFSKDFEQTGPYFKREVYHYPNQQRGAILWYHDHAMALT RLNVYAGLVGAYIIHDPKEKRLKLPSDEYDVPLLITDRTINEDGSLFYPSAPENPSPS LPNPSIVPAFCGETILVNGKVWPYLEVEPRKYRFRVINASNTRTYNLSLDNGGDFIQI GSDGGLLPRSVKLNSFSLAPAERYDIIIDFTAYEGESIILANSAGCGGDVNPETDANI MQFRVTKPLAQKDESRKPKYLASYPSVQHERIQNIRTLKLAGTQDEYGRPVLLLNNKR WHDPVTETPKVGTTEIWSIINPTRGTHPIHLHLVSFRVLDRRPFDIARYQESGELSYT GPAVPPPPSEKGWKDTIQAHAGEVLRIAATFGPYSGRYVWHCHILEHEDYDMMRPMDI TDPHK*" /label="cotA CDS" gene complement(633039..634580) /gene="cotA" /locus_tag="BSU_06300" /old_locus_tag="BSU06300" /label="cotA gene" downshifts complement(633052) /Source="Nicolas_upshifts" /id="D308" /incds=0 /nref=46 /ntot=93 /MaxReadThrough="2.97674" /MaxDrop="5.60726" /score="22.3755425" /energy="-9.1" /TU="U488" /idTUdmin="U488" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(634611..634630) /Source="Nicolas_upshift_promotors" /id="U488" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1297 /SigmaFactorBS="tcttcttcgggcgggctgcagcacgaagatttTTTGTAACCA tcacgtccttattGTCATTAACTATAGTACCAAtttggaaaatttagataaggacaga t" /listShort="cotA" /listLong="yeaA, ydjP, ydjO, S226" /label="promotor_-10" upshifts complement(634625) /Source="Nicolas_upshifts" /id="U488" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1297 /SigmaFactorBS="tcttcttcgggcgggctgcagcacgaagatttTTTGTAACCA tcacgtccttattGTCATTAACTATAGTACCAAtttggaaaatttagataaggacaga t" /listShort="cotA" /listLong="yeaA, ydjP, ydjO, S226" /label="upshifts" promotor_-35 complement(634644..634653) /Source="Nicolas_upshift_promotors" /id="U488" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1297 /SigmaFactorBS="tcttcttcgggcgggctgcagcacgaagatttTTTGTAACCA tcacgtccttattGTCATTAACTATAGTACCAAtttggaaaatttagataaggacaga t" /listShort="cotA" /listLong="yeaA, ydjP, ydjO, S226" /label="promotor_-35" CDS complement(634732..636141) /gene="gabP" /locus_tag="BSU_06310" /old_locus_tag="BSU06310" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15849754, 16547045, 16850406, 8951816, 9677314, 24142252" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16547045, 16850406, 8951816, 9677314, 24142252; Product type t : transporter" /codon_start=1 /transl_table=11 /product="gamma-aminobutyrate (GABA) permease; proline permease" /protein_id="NP_388512.2" /db_xref="EnsemblGenomes-Gn:BSU06310" /db_xref="EnsemblGenomes-Tr:CAB12450" /db_xref="GOA:P46349" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="InterPro:IPR011265" /db_xref="SubtiList:BG11328" /db_xref="UniProtKB/Swiss-Prot:P46349" /translation="MNQSQSGLKKELKTRHMTMISIAGVIGAGLFVGSGSVIHSTGPG AVVSYALAGLLVIFIMRMLGEMSAVNPTSGSFSQYAHDAIGPWAGFTIGWLYWFFWVI VIAIEAIAGAGIIQYWFHDIPLWLTSLILTIVLTLTNVYSVKSFGEFEYWFSLIKVVT IIAFLIVGFAFIFGFAPGSEPVGFSNLTGKGGFFPEGISSVLLGIVVVIFSFMGTEIV AIAAGETSNPIESVTKATRSVVWRIIVFYVGSIAIVVALLPWNSANILESPFVAVLEH IGVPAAAQIMNFIVLTAVLSCLNSGLYTTSRMLYSLAERNEAPRRFMKLSKKGVPVQA IVAGTFFSYIAVVMNYFSPDTVFLFLVNSSGAIALLVYLVIAVSQLKMRKKLEKTNPE ALKIKMWLFPFLTYLTIIAICGILVSMAFIDSMRDELLLTGVITGIVLISYLVFRKRK VSEKAAANPVTQQQPDILP*" /label="gabP CDS" gene complement(634732..636141) /gene="gabP" /locus_tag="BSU_06310" /old_locus_tag="BSU06310" /label="gabP gene" downshifts complement(634746) /Source="Nicolas_upshifts" /id="D309" /incds=0 /nref=124 /ntot=216 /MaxReadThrough="3.22899" /MaxDrop="5.0359" /score="18.985683" /energy="-13.5" /TU="U489" /idTUdmin="U489" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" CDS complement(636179..636466) /gene="ydzX" /locus_tag="BSU_06319" /old_locus_tag="BSU06319" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097690.1" /db_xref="EnsemblGenomes-Gn:BSU06319" /db_xref="EnsemblGenomes-Tr:CAX52577" /db_xref="UniProtKB/Swiss-Prot:C0H3X2" /translation="MIHPPQKNSDEGTLFLSSNLFAPPKIPSNPRTPVLLAFYRIVNI TQNHTANKKRNIFSTHSLKAQTKHYKFEISWYIFLHEFSTNCIFMIEFQLS*" /label="ydzX CDS" gene complement(636179..636466) /gene="ydzX" /locus_tag="BSU_06319" /old_locus_tag="BSU06319" /label="ydzX gene" misc_feature complement(636182..636201) /Source="Nicolas_upshift_promotors" /id="U489" /multdbtbs="SigA,SigA" /comp="M14" /sig="SigA" /pcomp="0.447552447552448" /psig="0.996003996003996" /xcortree=2898 /SigmaFactorBS="tttgaaataagctggtatattttcttacacgaattttcgaca aactgtatatttaTGATAGAGTTTCAATTATCAtaatattcagtaatgattgcatttt a" /listShort="gabP" /listLong="cotA" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(636196) /Source="Nicolas_upshifts" /id="U489" /multdbtbs="SigA,SigA" /comp="M14" /sig="SigA" /pcomp="0.447552447552448" /psig="0.996003996003996" /xcortree=2898 /SigmaFactorBS="tttgaaataagctggtatattttcttacacgaattttcgaca aactgtatatttaTGATAGAGTTTCAATTATCAtaatattcagtaatgattgcatttt a" /listShort="gabP" /listLong="cotA" /label="upshifts" promotor_-35 636472..636479 /Source="Nicolas_upshift_promotors" /id="U490" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.748251748251748" /psig="0.999000999001" /xcortree=1749 /SigmaFactorBS="cgtcactatttttctgtggcgggtgaatcatgtttcTGTAGA CCcactgcggatcagctTTGTAAGATAATAATAGGAAaatgtgagcgagaggaggttt t" /listShort="yeaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 636495..636514 /Source="Nicolas_upshift_promotors" /id="U490" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.748251748251748" /psig="0.999000999001" /xcortree=1749 /SigmaFactorBS="cgtcactatttttctgtggcgggtgaatcatgtttcTGTAGA CCcactgcggatcagctTTGTAAGATAATAATAGGAAaatgtgagcgagaggaggttt t" /listShort="yeaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 636496 /Source="Nicolas_upshifts" /id="U490" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.748251748251748" /psig="0.999000999001" /xcortree=1749 /SigmaFactorBS="cgtcactatttttctgtggcgggtgaatcatgtttcTGTAGA CCcactgcggatcagctTTGTAAGATAATAATAGGAAaatgtgagcgagaggaggttt t" /listShort="yeaB" /GFF_Attribute="listLong" /label="upshifts" CDS 636539..637411 /gene="mneS" /locus_tag="BSU_06320" /old_locus_tag="BSU06320" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:27748968" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 27748968; Product type t: transporter" /codon_start=1 /transl_table=11 /product="secondary Mn(II) exporter, promiscuous" /protein_id="NP_388513.1" /db_xref="EnsemblGenomes-Gn:BSU06320" /db_xref="EnsemblGenomes-Tr:CAB12451" /db_xref="GOA:P46348" /db_xref="InterPro:IPR002524" /db_xref="InterPro:IPR027469" /db_xref="InterPro:IPR027470" /db_xref="InterPro:IPR036837" /db_xref="SubtiList:BG11329" /db_xref="UniProtKB/Swiss-Prot:P46348" /translation="MERYDELKKGESGALVSIAAYLVLSAIKLIIGYLFHSEALTADG LNNTTDIIASVAVLIGLRISQKPPDEDHPYGHFRAETIASLIASFIMMVVGLQVLFSA GESIFSAKQETPDMIAAWTAAGGAVLMLIVYRYNKRLAKKVKSQALLAAAADNKSDAF VSIGTFIGIVAAQFHLAWIDTVTAFVIGLLICKTAWDIFKESSHSLTDGFDIKDISAY KQTIEKISGVSRLKDIKARYLGSTVHVDVVVEVSADLNITESHDIANEIERRMKEEHA IDYSHVHMEPLEQK*" /label="mneS CDS" gene 636539..637411 /gene="mneS" /locus_tag="BSU_06320" /old_locus_tag="BSU06320" /label="mneS gene" downshifts 637376 /Source="Nicolas_upshifts" /id="D310" /incds=0 /nref=2 /ntot=88 /MaxReadThrough="1.72291" /MaxDrop="2.86431" /score="24.8167732" /energy="-10.2" /TU="U490" /idTUdmin="U490" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" downshifts complement(637651) /Source="Nicolas_upshifts" /id="D311" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="0.65827" /MaxDrop="3.33542" /score="-0.424989042" /energy="-12.9" /TU="NA" /idTUdmin="U489" /TUdmin="-3015" /isTUend="FALSE" /label="downshifts" misc_feature 637705..637724 /Source="Nicolas_upshift_promotors" /id="U491" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2248 /SigmaFactorBS="ctttattggtaacaatttgctagaatcgtttttttatacaga ttgcttttTGTGGTAAAGTTAGGTTACAttatgatgaattttgtagatgactaggagg a" /listShort="yeaC, yeaD, yebA" /listLong="S227, guaA" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 637715 /Source="Nicolas_upshifts" /id="U491" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2248 /SigmaFactorBS="ctttattggtaacaatttgctagaatcgtttttttatacaga ttgcttttTGTGGTAAAGTTAGGTTACAttatgatgaattttgtagatgactaggagg a" /listShort="yeaC, yeaD, yebA" /listLong="S227, guaA" /label="upshifts" CDS 637761..638723 /gene="yeaC" /locus_tag="BSU_06330" /old_locus_tag="BSU06330" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 21907250, 26933057; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative MoxR-like ATPase" /protein_id="NP_388514.2" /db_xref="EnsemblGenomes-Gn:BSU06330" /db_xref="EnsemblGenomes-Tr:CAB12452" /db_xref="GOA:P94474" /db_xref="InterPro:IPR011703" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12211" /db_xref="UniProtKB/Swiss-Prot:P94474" /translation="MAYQEDLHPLLGKAVEHINRVMVGKRDIAILSLAALLAKGHVLL EDVPGVGKTMMVRALAKSIGADFKRIQFTPDLLPSDVTGVSIYNAKTMEFEYRPGPIM GNIVLADEINRTSPKTQSALLEAMEEGSVTVDGHTMQLADPFFVMATQNPVEYEGTYP LPEAQLDRFLFKLRMGYPSFNEELDVLSLQEKSHPIETLEPVIAKEDFIFLQREVQNV RADDSIKEYIVEIVQKTRQHPSVQLGVSPRGSIALMKAAQAYALLHHRDYVIPDDIQY LAPFTLPHRMMLHPEAKFEGIQAEAIVREIMSAVKVPVQRSAVR*" /label="yeaC CDS" gene 637761..638723 /gene="yeaC" /locus_tag="BSU_06330" /old_locus_tag="BSU06330" /label="yeaC gene" CDS 638723..639919 /gene="yeaD" /locus_tag="BSU_06340" /old_locus_tag="BSU06340" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388515.2" /db_xref="EnsemblGenomes-Gn:BSU06340" /db_xref="EnsemblGenomes-Tr:CAB12453" /db_xref="InterPro:IPR002881" /db_xref="InterPro:IPR036465" /db_xref="SubtiList:BG12212" /db_xref="UniProtKB/Swiss-Prot:P94475" /translation="MNKKWQWLVYGWKLIILTLLTAAVFSYAMFQGGFVSWFLFYAFL PFVLYAGLLALYPLRSFQASRQMDKTQLHAGDRLGVTVTLRRKLPFPLMYMVIEDCLP EGIESLNRDGAAAKRLVFPWFKRSMTMSYELARVPRGEHHFHSVRVRTGDVLGLIEKT AFFELDDTLFVYPFYQRFSYQVNERHQEDGVSGSSPIHQHHSSVAASVRNYQPGDRFA ALDWKTSARRSQLMTKEFEPSRSKNLFLLMDRFSSDAFEEVVSVTASILHSVLKNGAG AGLASIGKEKNIFPIQEGDQHFKHMLRHLAIAHCDAADPISRYAREELGKPSVRQADQ VVVTGQLTEDMLHLAEIGGGRVTVILAKEKDAELSQAENVMIERMMKRQIRVRIMRGG RVSRVV*" /label="yeaD CDS" gene 638723..639919 /gene="yeaD" /locus_tag="BSU_06340" /old_locus_tag="BSU06340" /label="yeaD gene" CDS 639941..642154 /gene="yebA" /locus_tag="BSU_06350" /old_locus_tag="BSU06350" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388516.2" /db_xref="EnsemblGenomes-Gn:BSU06350" /db_xref="EnsemblGenomes-Tr:CAB12454" /db_xref="GOA:P94476" /db_xref="InterPro:IPR002931" /db_xref="InterPro:IPR025403" /db_xref="InterPro:IPR036985" /db_xref="SubtiList:BG12213" /db_xref="UniProtKB/Swiss-Prot:P94476" /translation="MPHDDHKGSRLSLLLFYFLAFLLLWEWLRPLDSFTETKHTGFFS VFIGLTFLLTFFRMRWFVTVPFCVIFTLISIHILFYQGSIFDLSWVSSFLQDVYLNIT LIQSGQWNDMIPSFRTLLFFVLLWLLVYLLHYWVIYQRRILFFFLMTVAYITILDTFT PYDATFAVIRIVLIGFFMLGLLYLERIKLMERITLPKTSVLKWFLPLSVLVLAATGFG LAAPKSEPAWPDPVPFLKKITHQDRVSAGESKIGYGNHDESLGGPFQQDATPVFTWQG KERTYFRVETKDTYTGKGWIETDTGMSYQLSNGKVENLWFDHKVATERRTVRVKVDKH YGYNHLMYPIGAETIQPKQAVSLEMNGNTEQISPISEQAGEIRNMGNYTVTYNSPVYK LDELRKVKVRKNSEEYTFSDRYMQLPDSLPERVRTLAIKLTQDHDNMFDKVKAVEDYL GSNAFTYETENVTIPKNDEDYVDQFLFETKMGYCDNFSSAMVVLLRSAGIPARWVKGY TSGEYKEAGNKNGSIYEVTNNNAHSWVEVYFPEQGWVTFEPTKGFTNPAQFTSSDTKD SGSDSSSSPKKAKEKQKEEKKQPQKEEKQKEKREPAVSKKPSASHTNAGAGLYAALAV LAVLLVAAVLLYVFRSLWIPVFAVRKLKRRSDQHAFFEAYGALLKQLKRKGLPKRDSE TLRDYAKRIDEKYDIEDMSKLTLSYERALYRNEDSSALWNDSRELWENLIKRRWS*" /label="yebA CDS" gene 639941..642154 /gene="yebA" /locus_tag="BSU_06350" /old_locus_tag="BSU06350" /label="yebA gene" promotor_-35 642149..642156 /Source="Nicolas_upshift_promotors" /id="U492" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.912087912087912" /psig="0.999000999001" /xcortree=2555 /SigmaFactorBS="aaatttaattaaaagaagatggTCTTGACCgcttatcgacgt gtTGTTAGAATTAGTGAATATTatcggagtctgggagcgagttggcctgactccggca a" /listShort="S227, guaA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 642171..642190 /Source="Nicolas_upshift_promotors" /id="U492" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.912087912087912" /psig="0.999000999001" /xcortree=2555 /SigmaFactorBS="aaatttaattaaaagaagatggTCTTGACCgcttatcgacgt gtTGTTAGAATTAGTGAATATTatcggagtctgggagcgagttggcctgactccggca a" /listShort="S227, guaA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 642187..642316 /Source="Nicolas_S_feature" /locus_tag="new_692610_692739" /HighExp="G180, Oxctl, G135, LBGexp, G150, Paraq, C30, LPh, MG 25, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.63292099999999996" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigA" /TUlongPSig=1 /label="S227" upshifts 642187 /Source="Nicolas_upshifts" /id="U492" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.912087912087912" /psig="0.999000999001" /xcortree=2555 /SigmaFactorBS="aaatttaattaaaagaagatggTCTTGACCgcttatcgacgt gtTGTTAGAATTAGTGAATATTatcggagtctgggagcgagttggcctgactccggca a" /listShort="S227, guaA" /GFF_Attribute="listLong" /label="upshifts" CDS 642317..643858 /gene="guaA" /locus_tag="BSU_06360" /old_locus_tag="BSU06360" /EC_number="6.3.5.2" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1312531, 21856856; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GMP synthetase" /protein_id="NP_388517.2" /db_xref="EnsemblGenomes-Gn:BSU06360" /db_xref="EnsemblGenomes-Tr:CAB12455" /db_xref="GOA:P29727" /db_xref="InterPro:IPR001674" /db_xref="InterPro:IPR004739" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR017926" /db_xref="InterPro:IPR022310" /db_xref="InterPro:IPR022955" /db_xref="InterPro:IPR025777" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG10647" /db_xref="UniProtKB/Swiss-Prot:P29727" /translation="MTKLVNEMILVLDFGSQYNQLITRRIREFGVYSELHPHTLTAEE IKKMNPKGIILSGGPNSVYDENSFRCDEKIFELDIPVLGICYGMQLMTHYLGGKVEAA SQREYGKANIRIEGTPDLFRDLPNEQVVWMSHGDLVVEVPEGFTVDATSHHCPNSAMS KADKKWYGVQFHPEVRHSEYGNDLLKNFVFGVCECEGEWSMENFIEIEMQKIRETVGD KQVLCALSGGVDSSVVAVLIHKAIGDQLTCIFVDHGLLRKGEAEGVMKTFSEGFNMNV IKVDAKDRFLNKLKGVSDPEQKRKIIGNEFIYVFDDEADKLKGIDYLAQGTLYTDIIE SGTATAQTIKSHHNVGGLPEDMQFELIEPLNTLFKDEVRALGTELGIPDEIVWRQPFP GPGLGIRVLGEVTEEKLEIVRESDAILREEIANHGLERDIWQYFTVLPDIRSVGVMGD ARTYDYTIGIRAVTSIDGMTSDWARIPWDVLEVISTRIVNEVKHINRVVYDITSKPPA TIEWE*" /label="guaA CDS" gene 642317..643858 /gene="guaA" /locus_tag="BSU_06360" /old_locus_tag="BSU06360" /label="guaA gene" downshifts 643844 /Source="Nicolas_upshifts" /id="D312" /incds=0 /nref=247 /ntot=268 /MaxReadThrough="2.12151" /MaxDrop="7.3702" /score="22.5795134" /energy="-18.5" /TU="NA" /idTUdmin="U492" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 643965..643969 /Source="Nicolas_upshift_promotors" /id="U493" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.767232767232767" /psig=1 /xcortree=2631 /SigmaFactorBS="cgattttgcgcgactattgttcgctttttgTATTGttttttc aaaatgaaCTTGGTACAATAGACACAGAaatcaaataagatgaattcgtataatcgcg g" /listShort="NA, pbuG" /listLong="S228, yebC" /label="promotor_-35" promotor_-10 643985..644004 /Source="Nicolas_upshift_promotors" /id="U493" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.767232767232767" /psig=1 /xcortree=2631 /SigmaFactorBS="cgattttgcgcgactattgttcgctttttgTATTGttttttc aaaatgaaCTTGGTACAATAGACACAGAaatcaaataagatgaattcgtataatcgcg g" /listShort="NA, pbuG" /listLong="S228, yebC" /label="promotor_-10" upshifts 643995 /Source="Nicolas_upshifts" /id="U493" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.767232767232767" /psig=1 /xcortree=2631 /SigmaFactorBS="cgattttgcgcgactattgttcgctttttgTATTGttttttc aaaatgaaCTTGGTACAATAGACACAGAaatcaaataagatgaattcgtataatcgcg g" /listShort="NA, pbuG" /listLong="S228, yebC" /label="upshifts" misc_RNA 644002..644104 /gene="gswC" /locus_tag="BSU_misc_RNA_9" /product="guanine riboswitch" /experiment="publication(s) with functional evidences, PMID:12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477, 25023436, 27941758" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477, 25023436, 27941758; Product type n: RNA" /label="gswC RNA" gene 644002..644104 /gene="gswC" /locus_tag="BSU_misc_RNA_9" /label="gswC gene" downshifts 644130 /Source="Nicolas_upshifts" /id="D313" /incds=0 /nref=11 /ntot=56 /MaxReadThrough="8.01916" /MaxDrop="4.7859" /score="24.3821572" /energy="-11.3" /TU="U493" /idTUdmin="U492" /TUdmin=286 /isTUend="FALSE" /label="downshifts" CDS 644239..645561 /gene="pbuG" /locus_tag="BSU_06370" /old_locus_tag="BSU06370" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:3110131, 11591660, 12923093, 15849754, 16850406, 19446032" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3110131, 11591660, 12923093, 15849754, 16850406, 19446032; Product type t : transporter" /codon_start=1 /transl_table=11 /product="hypoxanthine/guanine permease" /protein_id="NP_388518.1" /db_xref="EnsemblGenomes-Gn:BSU06370" /db_xref="EnsemblGenomes-Tr:CAB12456" /db_xref="GOA:O34987" /db_xref="InterPro:IPR006043" /db_xref="InterPro:IPR026033" /db_xref="SubtiList:BG12811" /db_xref="UniProtKB/Swiss-Prot:O34987" /translation="MKTFFQFDELGTSYRNEIIGGLTTFLSMAYILFVNPITLALESV KDFPEALRIDQGAVFTATALASAAGCILMGLIARYPIAIAPGMGLNAFFAFSVVLGMG ISWQAALSGVFISGLIFVALSLTGFREKIINAIPPELKLAVGAGIGLFITFVGLQGSG IITANPSTLVTIGNIHSGPVLLTIFGVIVTVILMVLRVNAGVFIGMLLTAVAGMIFGL VPVPTQIIGSVPSLAPTFGQAWIHLPDIFSVQMLIVILTFLFVGFFDTAGTLVAVATQ AGLMKENKLPRAGRALLADSSSIVIGAVLGTSTTTSYVESSSGVAAGARSGFAAIVTG ILFLLATFFSPLLSVVTSNVTAPALIIVGALMVAPLGKIAWDKFEVAVPAFLTMIMMP LTYSIATGIAIGFIFYPITMVCKGKAKEVHPIMYGLFVVFILYFIFLK*" /label="pbuG CDS" gene 644239..645561 /gene="pbuG" /locus_tag="BSU_06370" /old_locus_tag="BSU06370" /label="pbuG gene" downshifts 645539 /Source="Nicolas_upshifts" /id="D314" /incds=0 /nref=47 /ntot=153 /MaxReadThrough="4.18958" /MaxDrop="4.86237" /score="42.0241443" /energy="-13.4" /TU="U493" /idTUdmin="U493" /TUdmin="-86" /isTUend="FALSE" /label="downshifts" downshifts 645582 /Source="Nicolas_upshifts" /id="D315" /incds=0 /nref=1 /ntot=29 /MaxReadThrough="3.09696" /MaxDrop="3.87785" /score="42.0241443" /energy="-13.4" /TU="U493" /idTUdmin="U493" /TUdmin="-43" /isTUend="FALSE" /label="downshifts" promotor_-35 645611..645620 /Source="Nicolas_upshift_promotors" /id="U494" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1642 /SigmaFactorBS="aaccagctgcactggcagctggtttttttgttgcaaaagaTA AAACCATTtcatacgatataCCGTCATGTAGATGTGccgccatgctttacttaaatgg a" /listShort="S228, yebC" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 645631..645771 /Source="Nicolas_S_feature" /locus_tag="new_696054_696194" /HighExp="T1.30H, T1.0H, T2.0H, T0.30H, B60, T2.30H, T-0.40H, T0.0H, T3.0H, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.998" /TUlongSig="SigA" /TUlongPSig=1 /label="S228" upshifts 645631 /Source="Nicolas_upshifts" /id="U494" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1642 /SigmaFactorBS="aaccagctgcactggcagctggtttttttgttgcaaaagaTA AAACCATTtcatacgatataCCGTCATGTAGATGTGccgccatgctttacttaaatgg a" /listShort="S228, yebC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 645633..645648 /Source="Nicolas_upshift_promotors" /id="U494" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1642 /SigmaFactorBS="aaccagctgcactggcagctggtttttttgttgcaaaagaTA AAACCATTtcatacgatataCCGTCATGTAGATGTGccgccatgctttacttaaatgg a" /listShort="S228, yebC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 645772..646575 /gene="yebC" /locus_tag="BSU_06380" /old_locus_tag="BSU06380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388519.2" /db_xref="EnsemblGenomes-Gn:BSU06380" /db_xref="EnsemblGenomes-Tr:CAB12457" /db_xref="GOA:O34341" /db_xref="SubtiList:BG12812" /db_xref="UniProtKB/Swiss-Prot:O34341" /translation="MTEERKETFEEEINQSERIDADEEPLSRMSRKASRQSKQKQKQK QKPRQERGESTVKDKLASVWAAINRYCGFAFSILKSPAKTVVTDGFSHYKYGLISMLI FSIIFSIGNWFQLKASWNRPLGFGERHHAFYDGFLVVLVYLLIFFAVMVFAIWAVSRY MMKQKVTFREAAAVLGSLLVPVIAVSILWLIFAIVNIPMLTVLFTVLILFSIFFIIAL YVQRVYQAAQDAPIDYIYCVFAVVAIALLFTAVTWPFISEYITASLIPL*" /label="yebC CDS" gene 645772..646575 /gene="yebC" /locus_tag="BSU_06380" /old_locus_tag="BSU06380" /label="yebC gene" downshifts 646560 /Source="Nicolas_upshifts" /id="D316" /incds=0 /nref=218 /ntot=263 /MaxReadThrough="1.47691" /MaxDrop="7.03926" /score="33.0377004" /energy="-10.7" /TU="NA" /idTUdmin="U494" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 646643..646650 /Source="Nicolas_upshift_promotors" /id="U495" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig=1 /xcortree=527 /SigmaFactorBS="tgtcacactttttacaaatatatctaaaaaacaTAGTTGATt tgtaggattaacCCGTGTATGATGGGGAAAATgctgaaaacgtccagcgcaaaaacct t" /listShort="S229, yebD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 646664..646683 /Source="Nicolas_upshift_promotors" /id="U495" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig=1 /xcortree=527 /SigmaFactorBS="tgtcacactttttacaaatatatctaaaaaacaTAGTTGATt tgtaggattaacCCGTGTATGATGGGGAAAATgctgaaaacgtccagcgcaaaaacct t" /listShort="S229, yebD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 646670..646733 /Source="Nicolas_S_feature" /locus_tag="new_697093_697156" /HighExp="B60, S2, S7, S8, Lbstat, nit, S4, BC, BT, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S229" upshifts 646670 /Source="Nicolas_upshifts" /id="U495" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig=1 /xcortree=527 /SigmaFactorBS="tgtcacactttttacaaatatatctaaaaaacaTAGTTGATt tgtaggattaacCCGTGTATGATGGGGAAAATgctgaaaacgtccagcgcaaaaacct t" /listShort="S229, yebD" /GFF_Attribute="listLong" /label="upshifts" CDS 646734..646901 /gene="yebD" /locus_tag="BSU_06390" /old_locus_tag="BSU06390" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388520.3" /db_xref="EnsemblGenomes-Gn:BSU06390" /db_xref="EnsemblGenomes-Tr:CAB12458" /db_xref="InterPro:IPR025072" /db_xref="SubtiList:BG12813" /db_xref="UniProtKB/Swiss-Prot:O34904" /translation="MADVLRRAINQKKQFLKTKLLLSEFYQGRGEQLADYTLSELEKE YKSLQKMKKEI*" /label="yebD CDS" gene 646734..646901 /gene="yebD" /locus_tag="BSU_06390" /old_locus_tag="BSU06390" /label="yebD gene" downshifts 646908 /Source="Nicolas_upshifts" /id="D317" /incds=0 /nref=64 /ntot=163 /MaxReadThrough="2.85884" /MaxDrop="5.66286" /score="29.2645456" /energy="-9" /TU="NA" /idTUdmin="U495" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 646952..646958 /Source="Nicolas_upshift_promotors" /id="U496" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=744 /SigmaFactorBS="aggtgagtctgctgaaaagcgggcttttttgttttgATTTTG AaaaggcgagaaagaGGGTAAACTACTACTGTTCaacacataaaagcgtgtcgaaata t" /listShort="S230, yebE, yebG, NA, S231" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 646973..646991 /Source="Nicolas_upshift_promotors" /id="U496" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=744 /SigmaFactorBS="aggtgagtctgctgaaaagcgggcttttttgttttgATTTTG AaaaggcgagaaagaGGGTAAACTACTACTGTTCaacacataaaagcgtgtcgaaata t" /listShort="S230, yebE, yebG, NA, S231" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 646976..647062 /Source="Nicolas_S_feature" /locus_tag="new_697399_697485" /HighExp="Etha, Gly, M9-stat, Sw, B60, S4, S6, LPhT, S3, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.966" /TUlongSig="NA" /TUlongPSig="NA" /label="S230" upshifts 646976 /Source="Nicolas_upshifts" /id="U496" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=744 /SigmaFactorBS="aggtgagtctgctgaaaagcgggcttttttgttttgATTTTG AaaaggcgagaaagaGGGTAAACTACTACTGTTCaacacataaaagcgtgtcgaaata t" /listShort="S230, yebE, yebG, NA, S231" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 647041..647048 /Source="Nicolas_upshift_promotors" /id="U497" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.876123876123876" /psig="0.999000999001" /xcortree=2463 /SigmaFactorBS="cgtgtcgaaatattttgcttaagcttacgggcgaagcTGATT GTAaacggctcatttcTCTAGTAGAATATGAATGCTttgtgcaagctgaagagtaggg g" /listShort="yebE, yebG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 647062..647081 /Source="Nicolas_upshift_promotors" /id="U497" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.876123876123876" /psig="0.999000999001" /xcortree=2463 /SigmaFactorBS="cgtgtcgaaatattttgcttaagcttacgggcgaagcTGATT GTAaacggctcatttcTCTAGTAGAATATGAATGCTttgtgcaagctgaagagtaggg g" /listShort="yebE, yebG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 647064 /Source="Nicolas_upshifts" /id="U497" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.876123876123876" /psig="0.999000999001" /xcortree=2463 /SigmaFactorBS="cgtgtcgaaatattttgcttaagcttacgggcgaagcTGATT GTAaacggctcatttcTCTAGTAGAATATGAATGCTttgtgcaagctgaagagtaggg g" /listShort="yebE, yebG" /GFF_Attribute="listLong" /label="upshifts" CDS 647115..647669 /gene="yebE" /locus_tag="BSU_06400" /old_locus_tag="BSU06400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388521.2" /db_xref="EnsemblGenomes-Gn:BSU06400" /db_xref="EnsemblGenomes-Tr:CAB12459" /db_xref="GOA:O34624" /db_xref="InterPro:IPR019264" /db_xref="InterPro:IPR022930" /db_xref="SubtiList:BG12814" /db_xref="UniProtKB/Swiss-Prot:O34624" /translation="MMQTILSNGIAMVLIILIINIVYVSFFTIRMILTLKGQRYLAAG ISTIEILVYVTGLSLVLDNLDQIQNVIAYALGYGLGVIVGMKIEEKLALGYIMVNVIT KELDLDLPKQLREKGYGVTNWVAGGLEGDRTALQILTPRRYELQLYDTIKTLDSKAFI IAYEPKTIHGGFWVKAVKKRRIKE*" /label="yebE CDS" gene 647115..647669 /gene="yebE" /locus_tag="BSU_06400" /old_locus_tag="BSU06400" /label="yebE gene" CDS 647669..647866 /gene="yebG" /locus_tag="BSU_06410" /old_locus_tag="BSU06410" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388523.1" /db_xref="EnsemblGenomes-Gn:BSU06410" /db_xref="EnsemblGenomes-Tr:CAB12461" /db_xref="InterPro:IPR025930" /db_xref="SubtiList:BG12816" /db_xref="UniProtKB/Swiss-Prot:O34700" /translation="MAKPKKKKFEVTEQQTIDAVLQQMKEEGYLPVRRMEEPIFMEKK ENGSIQIVPCGKKIVFEGKLI*" /label="yebG CDS" gene 647669..647866 /gene="yebG" /locus_tag="BSU_06410" /old_locus_tag="BSU06410" /label="yebG gene" downshifts 647856 /Source="Nicolas_upshifts" /id="D318" /incds=0 /nref=2 /ntot=91 /MaxReadThrough="2.80904" /MaxDrop="2.65424" /score="17.462689" /energy="-17.6" /TU="U496" /idTUdmin="U497" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 647912..647919 /Source="Nicolas_upshift_promotors" /id="U498" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2428 /SigmaFactorBS="attagtagaatgaatttttgtatcgttcgataatatCGTTGA CAttatccatgtccgtTGTTAAGATAAACATGAAATcaaaacacgacctcatataatc t" /listShort="NA, S231, purE, purK, purB, purC, purS, purQ, purL, purF, S232, purM, purN, purH, purD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 647934..647953 /Source="Nicolas_upshift_promotors" /id="U498" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2428 /SigmaFactorBS="attagtagaatgaatttttgtatcgttcgataatatCGTTGA CAttatccatgtccgtTGTTAAGATAAACATGAAATcaaaacacgacctcatataatc t" /listShort="NA, S231, purE, purK, purB, purC, purS, purQ, purL, purF, S232, purM, purN, purH, purD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 647936 /Source="Nicolas_upshifts" /id="U498" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2428 /SigmaFactorBS="attagtagaatgaatttttgtatcgttcgataatatCGTTGA CAttatccatgtccgtTGTTAAGATAAACATGAAATcaaaacacgacctcatataatc t" /listShort="NA, S231, purE, purK, purB, purC, purS, purQ, purL, purF, S232, purM, purN, purH, purD" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 647946..648048 /gene="gswD" /locus_tag="BSU_misc_RNA_10" /product="guanine riboswitch" /experiment="publication(s) with functional evidences, PMID:12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477, 25023436, 27941758" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477, 25023436, 27941758; Product type n: RNA" /label="gswD RNA" gene 647946..648048 /gene="gswD" /locus_tag="BSU_misc_RNA_10" /label="gswD gene" S_feature 648049..648188 /Source="Nicolas_S_feature" /locus_tag="new_698472_698611" /HighExp="MG 10, MG 15, MG t5, BMM, MG 25, MG 5, HPh, GM 45, GM 90, M9-exp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 0.966" /TUlongSig="NA" /TUlongPSig="NA" /label="S231" CDS 648189..648677 /gene="purE" /locus_tag="BSU_06420" /old_locus_tag="BSU06420" /EC_number="5.4.99.18" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 12787499, 16138311, 9683488; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N5-carboxyaminoimidazole ribonucleotide mutase" /protein_id="NP_388524.1" /db_xref="EnsemblGenomes-Gn:BSU06420" /db_xref="EnsemblGenomes-Tr:CAB12462" /db_xref="GOA:P12044" /db_xref="InterPro:IPR000031" /db_xref="InterPro:IPR024694" /db_xref="InterPro:IPR033747" /db_xref="InterPro:IPR035893" /db_xref="SubtiList:BG10700" /db_xref="UniProtKB/Swiss-Prot:P12044" /translation="MQPLVGIIMGSTSDWETMKHACDILDELNVPYEKKVVSAHRTPD FMFEYAETARERGIKVIIAGAGGAAHLPGMTAAKTTLPVIGVPVQSKALNGMDSLLSI VQMPGGVPVATTSIGKAGAVNAGLLAAQILSAFDEDLARKLDERRENTKQTVLESSDQ LV*" /label="purE CDS" gene 648189..648677 /gene="purE" /locus_tag="BSU_06420" /old_locus_tag="BSU06420" /label="purE gene" CDS 648670..649812 /gene="purK" /locus_tag="BSU_06430" /old_locus_tag="BSU06430" /EC_number="6.3.4.18" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 8998996, 9683488, 21931218, 25372694; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N5-carboxyaminoimidazole ribonucleotide synthase" /protein_id="NP_388525.2" /db_xref="EnsemblGenomes-Gn:BSU06430" /db_xref="EnsemblGenomes-Tr:CAB12463" /db_xref="GOA:P12045" /db_xref="InterPro:IPR003135" /db_xref="InterPro:IPR005875" /db_xref="InterPro:IPR006115" /db_xref="InterPro:IPR011054" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="SubtiList:BG10701" /db_xref="UniProtKB/Swiss-Prot:P12045" /translation="MSKQIIYPGAVIGIIGGGQLGKMMAVSAKQMGYKVAVVDPVKDS PCGQVADVEITAHYNDREAIRKLAEISDIITYEFENIDYDALHWLKDHAYLPQGSELL LITQNRETEKKAIQSAGCEVAPYSIVKTKNELKQAVQELRLPAVLKTCRGGYDGKGQF VIKEEAQMEQAAALLEHGTCILESWVSFKMELSVIVVRSVNGEISTFPTAENIHHNNI LFQSIVPARVEKGIQQKAADLAVKLADELNLVGPLAVEMFLTEDGELLVNELAPRPHN SGHYTLDLCETSQFEQHIRAVCGLPLGKTDLLKPGMMVNLLGDEVKLVEEDPELLKEA KLYIYGKHEIKKGRKMGHITFMKQPEDEWIQEITNKWMNRDGGQAE*" /label="purK CDS" gene 648670..649812 /gene="purK" /locus_tag="BSU_06430" /old_locus_tag="BSU06430" /label="purK gene" CDS 649809..651104 /gene="purB" /locus_tag="BSU_06440" /old_locus_tag="BSU06440" /EC_number="4.3.2.2" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9622500, 9683488, 9890879, 11063569, 12787499; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="adenylosuccinate lyase" /protein_id="NP_388526.1" /db_xref="EnsemblGenomes-Gn:BSU06440" /db_xref="EnsemblGenomes-Tr:CAB12464" /db_xref="GOA:P12047" /db_xref="InterPro:IPR000362" /db_xref="InterPro:IPR004769" /db_xref="InterPro:IPR008948" /db_xref="InterPro:IPR019468" /db_xref="InterPro:IPR020557" /db_xref="InterPro:IPR022761" /db_xref="InterPro:IPR024083" /db_xref="PDB:1F1O" /db_xref="SubtiList:BG10702" /db_xref="UniProtKB/Swiss-Prot:P12047" /translation="MIERYSRPEMSAIWTDENRFQAWLEVEILACEAWAELGVIPKED VKVMRENASFDINRILEIEKDTRHDVVAFTRAVSESLGEERKWVHYGLTSTDVVDTAL SYLLKQANDILLKDLERFVDIIKEKAKEHKYTVMMGRTHGVHAEPTTFGLKLALWHEE MKRNLERFKQAKAGIEVGKISGAVGTYANIDPFVEQYVCEKLGLKAAPISTQTLQRDR HADYMATLALIATSIEKFAVEIRGLQKSETREVEEFFAKGQKGSSAMPHKRNPIGSEN MTGMARVIRGYMMTAYENVPLWHERDISHSSAERIILPDATIALNYMLNRFSNIVKNL TVFPENMKRNMDRTLGLIYSQRVLLALIDTGLTREEAYDTVQPKAMEAWEKQVPFREL VEAEEKITSRLSPEKIADCFDYNYHLKNVDLIFERLGLA*" /label="purB CDS" gene 649809..651104 /gene="purB" /locus_tag="BSU_06440" /old_locus_tag="BSU06440" /label="purB gene" promotor_-10 complement(650114..650133) /Source="Nicolas_upshift_promotors" /id="U499" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.791208791208791" /psig="0.993006993006993" /xcortree=1708 /SigmaFactorBS="tttcgctttttcttttataatgtcaacaaatctctcaagaTC CTTGAGcaaaatatcgtttgCCTGTTTTAATAAGTAGGAAagagccgtatcaacaacg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(650135) /Source="Nicolas_upshifts" /id="U499" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.791208791208791" /psig="0.993006993006993" /xcortree=1708 /SigmaFactorBS="tttcgctttttcttttataatgtcaacaaatctctcaagaTC CTTGAGcaaaatatcgtttgCCTGTTTTAATAAGTAGGAAagagccgtatcaacaacg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(650148..650155) /Source="Nicolas_upshift_promotors" /id="U499" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.791208791208791" /psig="0.993006993006993" /xcortree=1708 /SigmaFactorBS="tttcgctttttcttttataatgtcaacaaatctctcaagaTC CTTGAGcaaaatatcgtttgCCTGTTTTAATAAGTAGGAAagagccgtatcaacaacg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 651178..651903 /gene="purC" /locus_tag="BSU_06450" /old_locus_tag="BSU06450" /EC_number="6.3.2.6" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 2495272, 9683488, 10784038, 12787499, 26118696; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylaminoimidazole succinocarboxamide synthetase" /protein_id="NP_388527.1" /db_xref="EnsemblGenomes-Gn:BSU06450" /db_xref="EnsemblGenomes-Tr:CAB12465" /db_xref="GOA:P12046" /db_xref="InterPro:IPR001636" /db_xref="InterPro:IPR018236" /db_xref="InterPro:IPR028923" /db_xref="InterPro:IPR033934" /db_xref="SubtiList:BG10703" /db_xref="UniProtKB/Swiss-Prot:P12046" /translation="MNIVKNELLYEGKAKKIYKTDDENTLYVVYKDSATAFNGEKKAE ISGKGRLNNEISSLIFKHLHAKGINNHFIERISETEQLIKKVTIVPLEVVVRNVVAGS MSKRLGIPEGTELEQPIIEFYYKDDALGDPLITEDHIWLLKAATPEQVETIKSITTIV NEELQSIFDDCHVRLIDFKLEFGLDAEGQVLLADEISPDTCRLWDKETNEKLDKDLFR RNLGSLTDAYEEIFNRLGGIHHV*" /label="purC CDS" gene 651178..651903 /gene="purC" /locus_tag="BSU_06450" /old_locus_tag="BSU06450" /label="purC gene" CDS 651896..652150 /gene="purS" /locus_tag="BSU_06460" /old_locus_tag="BSU06460" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10784038, 12787499" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10784038, 12787499; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor required for phosphoribosylformylglycinamidine synthetase activity" /protein_id="NP_388528.1" /db_xref="EnsemblGenomes-Gn:BSU06460" /db_xref="EnsemblGenomes-Tr:CAB12466" /db_xref="GOA:P12049" /db_xref="InterPro:IPR003850" /db_xref="InterPro:IPR036604" /db_xref="PDB:1T4A" /db_xref="PDB:1TWJ" /db_xref="SubtiList:BG10704" /db_xref="UniProtKB/Swiss-Prot:P12049" /translation="MYKVKVYVSLKESVLDPQGSAVQHALHSMTYNEVQDVRIGKYME LTIEKSDRDLDVLVKEMCEKLLANTVIEDYRYEVEEVVAQ*" /label="purS CDS" gene 651896..652150 /gene="purS" /locus_tag="BSU_06460" /old_locus_tag="BSU06460" /label="purS gene" CDS 652147..652830 /gene="purQ" /locus_tag="BSU_06470" /old_locus_tag="BSU06470" /EC_number="6.3.5.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12787499, 15301530, 15301532, 10784038, 9683488" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12787499, 15301530, 15301532, 10784038, 9683488; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylformylglycinamidine synthetase subunit I" /protein_id="NP_388529.1" /db_xref="EnsemblGenomes-Gn:BSU06470" /db_xref="EnsemblGenomes-Tr:CAB12467" /db_xref="GOA:P12041" /db_xref="InterPro:IPR010075" /db_xref="InterPro:IPR017926" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG10706" /db_xref="UniProtKB/Swiss-Prot:P12041" /translation="MKFAVIVLPGSNCDIDMYHAVKDELGHEVEYVWHEETSLDGFDG VLIPGGFSYGDYLRCGAIARFANIMPAVKQAAAEGKPVLGVCNGFQILQELGLLPGAM RRNKDLKFICRPVELIVQNDETLFTASYEKGESITIPVAHGEGNFYCDDETLATLKEN NQIAFTYGSNINGSVSDIAGVVNEKGNVLGMMPHPERAVDELLGSADGLKLFQSIVKN WRETHVTTA*" /label="purQ CDS" gene 652147..652830 /gene="purQ" /locus_tag="BSU_06470" /old_locus_tag="BSU06470" /label="purQ gene" CDS 652814..655042 /gene="purL" /locus_tag="BSU_06480" /old_locus_tag="BSU06480" /EC_number="6.3.5.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12787499, 15301532, 10784038, 9683488, 21671997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12787499, 15301532, 10784038, 9683488, 21671997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylformylglycinamidine synthetase subunit II" /protein_id="NP_388530.2" /db_xref="EnsemblGenomes-Gn:BSU06480" /db_xref="EnsemblGenomes-Tr:CAB12468" /db_xref="GOA:P12042" /db_xref="InterPro:IPR010074" /db_xref="InterPro:IPR010918" /db_xref="InterPro:IPR016188" /db_xref="InterPro:IPR036676" /db_xref="InterPro:IPR036921" /db_xref="SubtiList:BG10705" /db_xref="UniProtKB/Swiss-Prot:P12042" /translation="MSLLLEPSKEQIKEEKLYQQMGVSDDEFALIESILGRLPNYTEI GIFSVMWSEHCSYKNSKPILRKFPTSGERVLQGPGEGAGIVDIGDNQAVVFKIESHNH PSALEPYQGAATGVGGIIRDVFSMGARPIAVLNSLRFGELTSPRVKYLFEEVVAGIAG YGNCIGIPTVGGEVQFDSSYEGNPLVNAMCVGLINHEDIKKGQAKGVGNTVMYVGAKT GRDGIHGATFASEEMSDSSEEKRSAVQVGDPFMEKLLLEACLEVIQCDALVGIQDMGA AGLTSSSAEMASKAGSGIEMNLDLIPQRETGMTAYEMMLSESQERMLLVIERGREQEI IDIFDKYDLEAVSVGHVTDDKMLRLTHKGEVVCELPVDALAEEAPVYHKPSQEPAYYR EFLETDVPAPQIEDANEMLKALLQQPTIASKEWVYDQYDYMVRTNTVVAPGSDAGVLR IRGTKKALAMTTDCNARYLYLDPEVGGKIAVAEAARNIICSGAEPLAVTDNLNFGNPE KPEIFWQIEKAADGISEACNVLSTPVIGGNVSLYNESNGTAIYPTPVIGMVGLIEDTA HITTQHFKQAGDLVYVIGETKPEFAGSELQKMTEGRIYGKAPQIDLDVELSRQKALLD AIKKGFVQSAHDVSEGGLGVAIAESVMTTENLGANVTVEGEAALLFSESQSRFVVSVK KEHQAAFEATVKDAVHIGEVTADGILAIQNQDGQQMIHAQTKELERVWKGAIPCLLKS KA*" /label="purL CDS" gene 652814..655042 /gene="purL" /locus_tag="BSU_06480" /old_locus_tag="BSU06480" /label="purL gene" downshifts complement(653062) /Source="Nicolas_upshifts" /id="D319" /incds=1 /nref=1 /ntot=47 /MaxReadThrough="0.69202" /MaxDrop="3.99287" /score="-6.56256716" /energy="-16.7" /TU="NA" /idTUdmin="U499" /TUdmin="-3147" /isTUend="FALSE" /label="downshifts" CDS 655018..656448 /gene="purF" /locus_tag="BSU_06490" /old_locus_tag="BSU06490" /EC_number="2.4.2.14" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9683488, 10049369, 12787499, 16321950, 17981983" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9683488, 10049369, 12787499, 16321950, 17981983; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamine phosphoribosylpyrophosphate amidotransferase" /protein_id="NP_388531.2" /db_xref="EnsemblGenomes-Gn:BSU06490" /db_xref="EnsemblGenomes-Tr:CAB12469" /db_xref="GOA:P00497" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR005854" /db_xref="InterPro:IPR017932" /db_xref="InterPro:IPR029055" /db_xref="InterPro:IPR029057" /db_xref="InterPro:IPR035584" /db_xref="PDB:1AO0" /db_xref="PDB:1GPH" /db_xref="SubtiList:BG10707" /db_xref="UniProtKB/Swiss-Prot:P00497" /translation="MLAEIKGLNEECGVFGIWGHEEAPQITYYGLHSLQHRGQEGAGI VATDGEKLTAHKGQGLITEVFQNGELSKVKGKGAIGHVRYATAGGGGYENVQPLLFRS QNNGSLALAHNGNLVNATQLKQQLENQGSIFQTSSDTEVLAHLIKRSGHFTLKDQIKN SLSMLKGAYAFLIMTETEMIVALDPNGLRPLSIGMMGDAYVVASETCAFDVVGATYLR EVEPGEMLIINDEGMKSERFSMNINRSICSMEYIYFSRPDSNIDGINVHSARKNLGKM LAQESAVEADVVTGVPDSSISAAIGYAEATGIPYELGLIKNRYVGRTFIQPSQALREQ GVRMKLSAVRGVVEGKRVVMVDDSIVRGTTSRRIVTMLREAGATEVHVKISSPPIAHP CFYGIDTSTHEELIASSHSVEEIRQEIGADTLSFLSVEGLLKGIGRKYDDSNCGQCLA CFTGKYPTEIYQDTVLPHVKEAVLTK*" /label="purF CDS" gene 655018..656448 /gene="purF" /locus_tag="BSU_06490" /old_locus_tag="BSU06490" /label="purF gene" S_feature 656449..656549 /Source="Nicolas_S_feature" /locus_tag="new_706872_706972" /HighExp="MG 15, MG 25, MG 10, MG 5, aero, S0, MG t5, Gly, LPh, GM 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S232" CDS 656550..657590 /gene="purM" /locus_tag="BSU_06500" /old_locus_tag="BSU06500" /EC_number="6.3.3.1" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9683488, 10508786, 12787499, 16321950; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylaminoimidazole synthetase" /protein_id="NP_388532.2" /db_xref="EnsemblGenomes-Gn:BSU06500" /db_xref="EnsemblGenomes-Tr:CAB12470" /db_xref="GOA:P12043" /db_xref="InterPro:IPR004733" /db_xref="InterPro:IPR010918" /db_xref="InterPro:IPR016188" /db_xref="InterPro:IPR036676" /db_xref="InterPro:IPR036921" /db_xref="SubtiList:BG10708" /db_xref="UniProtKB/Swiss-Prot:P12043" /translation="MSEAYKNAGVDIEAGYEAVKRMKKHVERTKRLGVMGSLGGFGGM FDLSELSYQKPVLISGTDGVGTKLKLAFSMDKHDTIGVDAVAMCVNDVLAQGAEPLFF LDYLAVGKADPVKIEQIVQGVAEGCEQSGSALVGGETAEMPGLYTADEYDIAGFSVGV AEKDEIVTGEKIEEGHLLIGLSSSGLHSNGFSLVRKVLLDDAELDLDTTYEPFERPLG EELLEPTRIYVKPVLAAVKSGKIDGMAHVTGGGFIENIPRMLPEGLSAEIDHGSWPIP PIFSFLQEYGKLKEEDMFNVFNMGIGFVLAVKEEHLTDVIGTLESHGEKAYLIGRVKK GEGVTFGGAALS*" /label="purM CDS" gene 656550..657590 /gene="purM" /locus_tag="BSU_06500" /old_locus_tag="BSU06500" /label="purM gene" CDS 657587..658174 /gene="purN" /locus_tag="BSU_06510" /old_locus_tag="BSU06510" /EC_number="2.1.2.2" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9683488, 10569930, 12787499, 19574646; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylglycinamide formyltransferase" /protein_id="NP_388533.2" /db_xref="EnsemblGenomes-Gn:BSU06510" /db_xref="EnsemblGenomes-Tr:CAB12471" /db_xref="GOA:P12040" /db_xref="InterPro:IPR001555" /db_xref="InterPro:IPR002376" /db_xref="InterPro:IPR004607" /db_xref="InterPro:IPR036477" /db_xref="SubtiList:BG10709" /db_xref="UniProtKB/Swiss-Prot:P12040" /translation="MKKFAVFASGNGSNFEAIVTRLKEENWDASAALLVCDKPQAKVI ERAEAFHIPSFAFEPKSYENKAAFEQAIIEQLRLHEVELIALAGYMRLIGDTLLQAYG GKIINIHPSLLPAFPGIDAVGQAFRAGVKVAGITVHYVDEGMDTGPIIAQKAIEIDEH DTLETIEQRIHKLEHKWYPSVIKQLLGLNNRGEKA*" /label="purN CDS" gene 657587..658174 /gene="purN" /locus_tag="BSU_06510" /old_locus_tag="BSU06510" /label="purN gene" misc_feature 657597..657611 /Source="Nicolas_upshift_promotors" /id="U500" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.52947052947053" /psig="0.52947052947053" /xcortree=2706 /SigmaFactorBS="aaaaaaggtgaaggcgtcacattcggcggtgcggcactttca tgaaaaagtTTGCGGTATTTGCATcaggaaacggttcaaacttcgaagccatcgtcac g" /listShort="purN, purH, purD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 657606 /Source="Nicolas_upshifts" /id="U500" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.52947052947053" /psig="0.52947052947053" /xcortree=2706 /SigmaFactorBS="aaaaaaggtgaaggcgtcacattcggcggtgcggcactttca tgaaaaagtTTGCGGTATTTGCATcaggaaacggttcaaacttcgaagccatcgtcac g" /listShort="purN, purH, purD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(657873..657891) /Source="Nicolas_upshift_promotors" /id="U501" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1204 /SigmaFactorBS="tccaggaaacgccggaagaagcgatgggTGAATGttaatgat ttttcccCCATATGCTTGAAGGAGCGtatcaccgatcagcctcatatagccggcaaga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(657880) /Source="Nicolas_upshifts" /id="U501" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1204 /SigmaFactorBS="tccaggaaacgccggaagaagcgatgggTGAATGttaatgat ttttcccCCATATGCTTGAAGGAGCGtatcaccgatcagcctcatatagccggcaaga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(657907..657912) /Source="Nicolas_upshift_promotors" /id="U501" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1204 /SigmaFactorBS="tccaggaaacgccggaagaagcgatgggTGAATGttaatgat ttttcccCCATATGCTTGAAGGAGCGtatcaccgatcagcctcatatagccggcaaga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 658171..659709 /gene="purH" /locus_tag="BSU_06520" /old_locus_tag="BSU06520" /EC_number="2.1.2.3" /EC_number="3.5.4.10" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12787499, 1937050, 9683488; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fused phosphoribosylaminoimidazole carboxy formyl formyltransferase; inosine-monophosphate cyclohydrolase" /protein_id="NP_388534.2" /db_xref="EnsemblGenomes-Gn:BSU06520" /db_xref="EnsemblGenomes-Tr:CAB12472" /db_xref="GOA:P12048" /db_xref="InterPro:IPR002695" /db_xref="InterPro:IPR011607" /db_xref="InterPro:IPR016193" /db_xref="InterPro:IPR024051" /db_xref="InterPro:IPR036914" /db_xref="SubtiList:BG10710" /db_xref="UniProtKB/Swiss-Prot:P12048" /translation="MTIKRALISVSDKTNLVPFVKELTELGVEVISTGGTKKLLQENG VDVIGISEVTGFPEIMDGRLKTLHPNIHGGLLAVRGNEEHMAQINEHGIQPIDLVVVN LYPFKETISKEDVTYEEAIENIDIGGPGMLRAASKNHQDVTVIVDPADYSPVLNQIKE EGSVSLQKKRELAAKVFRHTAAYDALIADYLTNVVGEKEPEQFTVTFEKKQSLRYGEN PHQEATFYQTALPVKGSIAQAEQLHGKELSYNNIKDADAAVQIVREFTEPAAVAVKHM NPCGVGTGKTIAEAFDRAFEADKTSIFGGIIALNREVDKATAEALHNIFLEIIIAPSF SQEALDVLTAKKNLRLLTLDVSAAVQKEKQLTSVQGGLLIQDLDMHGFDDAEISIPTK REPNEQEWEDLKLAWKVVKHVKSNAIVLAKDNMTVGVGAGQMNRVGSAKIAIEQAGEK AKGSALGSDAYFPMPDTVEEAAKAGVTAIIQPGGSIRDEDSIKKADEYGIAMVFTGIR HFKH*" /label="purH CDS" gene 658171..659709 /gene="purH" /locus_tag="BSU_06520" /old_locus_tag="BSU06520" /label="purH gene" CDS 659725..660993 /gene="purD" /locus_tag="BSU_06530" /old_locus_tag="BSU06530" /EC_number="6.3.4.13" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9683488, 12787499, 16321950" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9683488, 12787499, 16321950; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylglycinamide synthetase" /protein_id="NP_388535.1" /db_xref="EnsemblGenomes-Gn:BSU06530" /db_xref="EnsemblGenomes-Tr:CAB12473" /db_xref="GOA:P12039" /db_xref="InterPro:IPR000115" /db_xref="InterPro:IPR011054" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="InterPro:IPR020559" /db_xref="InterPro:IPR020560" /db_xref="InterPro:IPR020561" /db_xref="InterPro:IPR020562" /db_xref="InterPro:IPR037123" /db_xref="PDB:2XCL" /db_xref="PDB:2XD4" /db_xref="SubtiList:BG10711" /db_xref="UniProtKB/Swiss-Prot:P12039" /translation="MNVLIIGKGGREHTLAWKAAQSSLVENVFAAPGNDGMAASAQLV NIEESDHAGLVSFAKQNQVGLTIVGPEVPLIEGLVDEFEKAGLHVFGPSKAAAIIEGS KQFAKDLMKKYDIPTAEYETFTSFDEAKAYVQEKGAPIVIKADGLAAGKGVTVAMTEE EAIACLHDFLEDEKFGDASASVVIEEYLSGEEFSLMAFVKGEKVYPMVIAQDHKRAFD GDKGPNTGGMGAYSPVPQISEETVRHAVETIVKPAAKAMVQEGRSFTGVLYAGLMLTE NGSKVIEFNARFGDPETQVVLPRMESDLVQVLLDLLDDKEVDLRWKDTAAVSVVLASE GYPESYAKGTPIGSLAAETEQVVVFHAGTKAEGGEFVTNGGRVANVTAFDETFEAARD RVYKAVDEIFKPGLFFRKDIGARALKAAQK*" /label="purD CDS" gene 659725..660993 /gene="purD" /locus_tag="BSU_06530" /old_locus_tag="BSU06530" /label="purD gene" downshifts 660978 /Source="Nicolas_upshifts" /id="D320" /incds=0 /nref=140 /ntot=249 /MaxReadThrough="2.77191" /MaxDrop="5.90939" /score="30.0999687" /energy="-11.4" /TU="NA" /idTUdmin="U500" /TUdmin=6 /isTUend="TRUE" /label="downshifts" CDS complement(661033..661452) /gene="yezC" /locus_tag="BSU_06540" /old_locus_tag="BSU06540" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (Lrp/AsnC family)" /protein_id="NP_388536.2" /db_xref="EnsemblGenomes-Gn:BSU06540" /db_xref="EnsemblGenomes-Tr:CAB12474" /db_xref="GOA:O31497" /db_xref="InterPro:IPR000485" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR019885" /db_xref="InterPro:IPR019887" /db_xref="InterPro:IPR019888" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12874" /db_xref="UniProtKB/Swiss-Prot:O31497" /translation="MDDTDLQILSHLQRNGRLTMVELGKLVGLSSPSAAERVRKLEDK GVITGYSANICYEKLNKHVTAFILMEPKSCKHYAAFATSHPDVAENHRITGMYSYVTK VVTESVHTLEDFIDTSMAHGKPTTLVVLSSSSCHPAF*" /label="yezC CDS" gene complement(661033..661452) /gene="yezC" /locus_tag="BSU_06540" /old_locus_tag="BSU06540" /label="yezC gene" misc_feature complement(661522..661541) /Source="Nicolas_upshift_promotors" /id="U502" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig="0.999000999001" /xcortree=3125 /SigmaFactorBS="ccccctctctgattgatggctttattatagaaaaaataagac ggcatccaTATGCTACAATGAAGTTAAAtcaacagcattaccttacgatcaaaggaat t" /listShort="yezC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(661531) /Source="Nicolas_upshifts" /id="U502" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig="0.999000999001" /xcortree=3125 /SigmaFactorBS="ccccctctctgattgatggctttattatagaaaaaataagac ggcatccaTATGCTACAATGAAGTTAAAtcaacagcattaccttacgatcaaaggaat t" /listShort="yezC" /GFF_Attribute="listLong" /label="upshifts" CDS 661596..662870 /gene="yecA" /locus_tag="BSU_06550" /old_locus_tag="BSU06550" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 26319875, 27723097, 24678831; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative amino acid exporter" /protein_id="NP_388537.2" /db_xref="EnsemblGenomes-Gn:BSU06550" /db_xref="EnsemblGenomes-Tr:CAB12475" /db_xref="GOA:O34560" /db_xref="InterPro:IPR002293" /db_xref="SubtiList:BG12817" /db_xref="UniProtKB/Swiss-Prot:O34560" /translation="MLPELQRSITWIQGTALTIGAVLGCGILILPSVTADTAGPASLF VWVFMSFLSFFLVGTLARLVKIAPSAGGITAYVQLAFQKKAGAILGWIMLGSVPIGVP IIALTGAHYVSYITEAADWQITLIAGCMLAISILLHMRGIQLSANISTLVICVIVFLL VTSIAVSLPHVTIAEFKPFLPHGWSAAGSVSVMIFFSFVGWEMITPLAEEFHRPEKDV PLSLFLAASCVAGLYIMLSFVTVGTHSYGENGEIASLAMLISKGAGESGVYVTVCLAL FITFATIHANIAGFSRMVYALAREGHIPVFFGKLSATKRTPIRVLTAMAAVFGLVLAA HGLFQIDLTTLLKGPSAAFIASYICTMAAALKLLGRRDIGWWMALGAFVACAVIYSFS GWALLYPAVLAAAGYFYMKTKGGHKKKLDHVL*" /label="yecA CDS" gene 661596..662870 /gene="yecA" /locus_tag="BSU_06550" /old_locus_tag="BSU06550" /label="yecA gene" downshifts 662819 /Source="Nicolas_upshifts" /id="D321" /incds=0 /nref=4 /ntot=64 /MaxReadThrough="0.796809999999999" /MaxDrop="2.92696" /score="1.68718502" /energy="-14.2" /TU="NA" /idTUdmin="U498" /TUdmin=1825 /isTUend="FALSE" /label="downshifts" CDS complement(662885..663112) /gene="yezF" /locus_tag="BSU_06559" /old_locus_tag="BSU06559" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097691.1" /db_xref="EnsemblGenomes-Gn:BSU06559" /db_xref="EnsemblGenomes-Tr:CAX52578" /db_xref="GOA:C0H3X3" /db_xref="InterPro:IPR021309" /db_xref="UniProtKB/Swiss-Prot:C0H3X3" /translation="MKPNISLINAVFRIACGLTIMSAASAKFTKKPWCRMHLFYIFMG AMKAGSGILRFCPVTYMFQHSDSGNNEHQNG*" /label="yezF CDS" gene complement(662885..663112) /gene="yezF" /locus_tag="BSU_06559" /old_locus_tag="BSU06559" /label="yezF gene" downshifts complement(662896) /Source="Nicolas_upshifts" /id="D322" /incds=0 /nref=29 /ntot=46 /MaxReadThrough="0.14199" /MaxDrop="6.82335" /score="34.1397958" /energy="-13.9" /TU="NA" /idTUdmin="U504" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(663113..663533) /Source="Nicolas_S_feature" /locus_tag="new_713536_713956_c" /HighExp="S8, S7, S5, S6, S4, ferm, nit, BT, Pyr, T5.0H" /AntisenseName="yerA" /AntisenseCor="0.38264258041500998" /AntisenseRegPval="-10.1" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S233" promotor_-35 663180..663185 /Source="Nicolas_upshift_promotors" /id="U503" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.59040959040959" /psig=1 /xcortree=1592 /SigmaFactorBS="aaaagttttttaatcgaaccttcaaaaatttgtaacgttttt atCGTGCGtgatgaggaaggaTGTGATACCATGAGTCTAATacatgtaaaggagagta t" /listShort="yerA, yerB, yerC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 663196 /Source="Nicolas_upshifts" /id="U503" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.59040959040959" /psig=1 /xcortree=1592 /SigmaFactorBS="aaaagttttttaatcgaaccttcaaaaatttgtaacgttttt atCGTGCGtgatgaggaaggaTGTGATACCATGAGTCTAATacatgtaaaggagagta t" /listShort="yerA, yerB, yerC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 663199..663218 /Source="Nicolas_upshift_promotors" /id="U503" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.59040959040959" /psig=1 /xcortree=1592 /SigmaFactorBS="aaaagttttttaatcgaaccttcaaaaatttgtaacgttttt atCGTGCGtgatgaggaaggaTGTGATACCATGAGTCTAATacatgtaaaggagagta t" /listShort="yerA, yerB, yerC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 663241..664983 /gene="yerA" /locus_tag="BSU_06560" /old_locus_tag="BSU06560" /EC_number="3.5.4.2" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23109554; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative adenine deaminase YerA" /protein_id="NP_388538.1" /db_xref="EnsemblGenomes-Gn:BSU06560" /db_xref="EnsemblGenomes-Tr:CAB12476" /db_xref="GOA:O34909" /db_xref="InterPro:IPR006679" /db_xref="InterPro:IPR006680" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR026912" /db_xref="InterPro:IPR032466" /db_xref="SubtiList:BG12829" /db_xref="UniProtKB/Swiss-Prot:O34909" /translation="MSERTFNWKNKDIRAQVDVVDSKLLPTLLLRNALVLNPYVKQWL KKNIWIYQDRIVYVGHELPNRAEEIHTIDCEGKYIVPGYIEPHAHPFQIYNPQTLAEY VSQYGTTTFVNDNLFLLLQSGKKKALTILNELKKQPVQYFWWSRYDLQTEVLNEDHVL PFDVRKQWIEHPDVIQGGEMTGWPRLVDGDDLMLHCMQATKKQRKRIEGHFPGASDKT LTKMKLFGADCDHEAMTGDEVMRRLELGYYVSLRNSSIRPDVRKILQELHEKGFRYYD HFFYTTDGATPNFYKGGMTNELIRIALEEGVPAIDAYNMASFNIAKYYQMDDYLGVVG PGRLASLNILEDPLNPNPVTVLSKGTILRENGCDLKAFTKTDWHKGGLVPLELSYDMT MDDLQFSMPMGVKMRNAVIMEPYMIEIDNSMEQLSFDHDESYLTMLDRHGKWRVNTMI KGFASSVQGFVSSFTTTGDIVAIGKNKADMLLAFARMKEIGGGIVLAENGNILHEIPL ALCGCASSEAYEDVLEKEQKLRDLLTERGYEFCDPIYTLLFLQSTHLPYIRITPRGIF DVMKKTVLFPSIMR*" /label="yerA CDS" gene 663241..664983 /gene="yerA" /locus_tag="BSU_06560" /old_locus_tag="BSU06560" /label="yerA gene" promotor_-10 complement(663518..663529) /Source="Nicolas_upshift_promotors" /id="U504" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=923 /SigmaFactorBS="aaaaataagttatcattcacgaatgtcgttgttccgtattga gaCACATATtccgccagtgtttGGGGATTATATAtttgaaaaggatgtgcgtgcggtt c" /listShort="S233, yezF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(663533) /Source="Nicolas_upshifts" /id="U504" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=923 /SigmaFactorBS="aaaaataagttatcattcacgaatgtcgttgttccgtattga gaCACATATtccgccagtgtttGGGGATTATATAtttgaaaaggatgtgcgtgcggtt c" /listShort="S233, yezF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(663543..663549) /Source="Nicolas_upshift_promotors" /id="U504" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=923 /SigmaFactorBS="aaaaataagttatcattcacgaatgtcgttgttccgtattga gaCACATATtccgccagtgtttGGGGATTATATAtttgaaaaggatgtgcgtgcggtt c" /listShort="S233, yezF" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 663564 /Source="Nicolas_upshifts" /id="D323" /incds=1 /nref=13 /ntot=109 /MaxReadThrough="7.92321" /MaxDrop="3.44855" /score="1.68718502" /energy="-14.2" /TU="U503" /idTUdmin="U498" /TUdmin=2570 /isTUend="FALSE" /label="downshifts" promotor_-35 664957..664963 /Source="Nicolas_upshift_promotors" /id="U505" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.4995004995005" /psig="0.996003996003996" /xcortree=2171 /SigmaFactorBS="cgcattacgccaagaggaatattcgacgtcatgaaaaaaact GTACTCTttccatcgataaTGCGTTAAAATATAAAAGAGcagggagccgacatatgaa a" /listShort="yerB, yerC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 664975 /Source="Nicolas_upshifts" /id="U505" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.4995004995005" /psig="0.996003996003996" /xcortree=2171 /SigmaFactorBS="cgcattacgccaagaggaatattcgacgtcatgaaaaaaact GTACTCTttccatcgataaTGCGTTAAAATATAAAAGAGcagggagccgacatatgaa a" /listShort="yerB, yerC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 664976..664995 /Source="Nicolas_upshift_promotors" /id="U505" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.4995004995005" /psig="0.996003996003996" /xcortree=2171 /SigmaFactorBS="cgcattacgccaagaggaatattcgacgtcatgaaaaaaact GTACTCTttccatcgataaTGCGTTAAAATATAAAAGAGcagggagccgacatatgaa a" /listShort="yerB, yerC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 665010..666005 /gene="yerB" /locus_tag="BSU_06570" /old_locus_tag="BSU06570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12073041; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_388539.1" /db_xref="EnsemblGenomes-Gn:BSU06570" /db_xref="EnsemblGenomes-Tr:CAB12477" /db_xref="GOA:O34968" /db_xref="InterPro:IPR021416" /db_xref="InterPro:IPR023158" /db_xref="InterPro:IPR035328" /db_xref="PDB:2PSB" /db_xref="SubtiList:BG12830" /db_xref="UniProtKB/Swiss-Prot:O34968" /translation="MKKWMTVCALCFVFFLLVSCQQKDAVPDTAKKLKAPLTGLKTEQ KVTERRPVAVVVNNHPKARPQSGLSKADIVIEALAEGQITRFLAIFQSQMPETVGPVR SAREYFVTLSNGFDSIFVHHGWSPGAKKQLESGAADYMNGLDFDGSLFWRADFSKPPH NSYTSYDYIKKAAEQKGYKLKQETNPLLFQTSDAKPANESYNVRVDYGTNNVTNLVEY NYDKKAEFYTRSSDGVITTDRETGKPVAMQNIFIVEASHHIIDQDGRRDIDLESGGKG LLFQHGNVIETDWKQVNGRIVPVKDGKWLPFVPGKTWINIVPDLDAASISKGEGV*" /label="yerB CDS" gene 665010..666005 /gene="yerB" /locus_tag="BSU_06570" /old_locus_tag="BSU06570" /label="yerB gene" CDS 666008..666322 /gene="yerC" /locus_tag="BSU_06580" /old_locus_tag="BSU06580" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 23504016, 26735940; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor-histidine operons" /protein_id="NP_388540.1" /db_xref="EnsemblGenomes-Gn:BSU06580" /db_xref="EnsemblGenomes-Tr:CAB12478" /db_xref="GOA:Q7BVT7" /db_xref="InterPro:IPR000831" /db_xref="InterPro:IPR010921" /db_xref="InterPro:IPR013368" /db_xref="SubtiList:BG12831" /db_xref="UniProtKB/Swiss-Prot:Q7BVT7" /translation="MQIDKLRGKELDQLFNSILSLKDLEECYRFFDDLCTINEIQSLA QRLEVARMLREGNTYHKIETETGASTATISRVKRCLNYGNDAYEMALDRVKETETESS SK*" /label="yerC CDS" gene 666008..666322 /gene="yerC" /locus_tag="BSU_06580" /old_locus_tag="BSU06580" /label="yerC gene" downshifts 666185 /Source="Nicolas_upshifts" /id="D324" /incds=1 /nref=1 /ntot=25 /MaxReadThrough="7.1005" /MaxDrop="2.3494" /score="10.9674476" /energy="-15.8" /TU="U503,U505" /idTUdmin="U503" /TUdmin="-374" /isTUend="FALSE" /label="downshifts" downshifts 666327 /Source="Nicolas_upshifts" /id="D325" /incds=0 /nref=78 /ntot=262 /MaxReadThrough="3.58776" /MaxDrop="5.59364" /score="10.9674476" /energy="-15.8" /TU="U503,U505" /idTUdmin="U503" /TUdmin="-232" /isTUend="FALSE" /label="downshifts" CDS complement(666357..667934) /gene="yerD" /locus_tag="BSU_06590" /old_locus_tag="BSU06590" /EC_number="1.4.1.13" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15805528, 17114254, 19948795; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative osmotic shock glutamate synthase subunit (flavoprotein subunit, ferredoxin-dependent)" /protein_id="NP_388541.1" /db_xref="EnsemblGenomes-Gn:BSU06590" /db_xref="EnsemblGenomes-Tr:CAB12479" /db_xref="GOA:O34849" /db_xref="InterPro:IPR002932" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR024188" /db_xref="InterPro:IPR027283" /db_xref="SubtiList:BG12832" /db_xref="UniProtKB/Swiss-Prot:O34849" /translation="METIIIALIAFIIGIIAIPIVLFAWIYIKDEKQQEHSILRNYPV IGRFRYILEKIGPELRQYLYSNDNEEQPFSRKEYEQTVISGKYKSRMMGFGSVRDFDK PGYYIRNAMFPKQREEMHVNQTPKIETQIYKMDADNLFKRKEHAEHIKADPYFLHPDD VQVIGEHTCEKPFYVKGLVGQSAMSYGSLGERAVTALSKGLHLAGGTWMNTGEGGLSE YHLKGGADIICQIGPGLFGVRKRNGEFSWEEFKRKSRIDQIKAFELKLAQGAKTRGGH VDGAKVSEEVADIRNVEPGKSIDSPNRFYEFSNPPEMLDFIEKLRDVGQKPVGIKLVA GHPEELHELFSHMQKSGKHPDFITIDGSEGGTGASFYELADTVGLPIMTALPIVDTLL KQYGLRSQLKIFASGKLLTPDKIAVALALGADFVNIARGMMFSVGCIRALVCHTNTCP AGVATTDPKLQKALSVEEKQHRVCNYVISLREGLFNLAAAAGINSPIHFSKEHVVYRK EDGSIINIDNLIHQFVS*" /label="yerD CDS" gene complement(666357..667934) /gene="yerD" /locus_tag="BSU_06590" /old_locus_tag="BSU06590" /label="yerD gene" downshifts complement(666371) /Source="Nicolas_upshifts" /id="D326" /incds=0 /nref=7 /ntot=24 /MaxReadThrough="2.99325" /MaxDrop="5.6389" /score="34.8793815" /energy="-15.8" /TU="U506" /idTUdmin="U506" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(667948..667967) /Source="Nicolas_upshift_promotors" /id="U506" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=244 /SigmaFactorBS="ggcaggagcacacatttttcaccagattccttctgctatTGT TTGGaaagtgttctactgTGGAAATGGTTACATAAAAAgggaggctgagagatggaaa c" /listShort="yerD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(667967) /Source="Nicolas_upshifts" /id="U506" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=244 /SigmaFactorBS="ggcaggagcacacatttttcaccagattccttctgctatTGT TTGGaaagtgttctactgTGGAAATGGTTACATAAAAAgggaggctgagagatggaaa c" /listShort="yerD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(667982..667988) /Source="Nicolas_upshift_promotors" /id="U506" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=244 /SigmaFactorBS="ggcaggagcacacatttttcaccagattccttctgctatTGT TTGGaaagtgttctactgTGGAAATGGTTACATAAAAAgggaggctgagagatggaaa c" /listShort="yerD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 668131..668134 /Source="Nicolas_upshift_promotors" /id="U507" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2610 /SigmaFactorBS="aaaacacctttttcagtgaataacgagattaacggctttttc cGTTTttccgcgctatgtgaaTTTGTTATAATGTTTAAATGgtaacaaacgaatggag g" /listShort="pcrB, pcrA, ligA, yerH, S234, yerI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 668148 /Source="Nicolas_upshifts" /id="U507" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2610 /SigmaFactorBS="aaaacacctttttcagtgaataacgagattaacggctttttc cGTTTttccgcgctatgtgaaTTTGTTATAATGTTTAAATGgtaacaaacgaatggag g" /listShort="pcrB, pcrA, ligA, yerH, S234, yerI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 668151..668170 /Source="Nicolas_upshift_promotors" /id="U507" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2610 /SigmaFactorBS="aaaacacctttttcagtgaataacgagattaacggctttttc cGTTTttccgcgctatgtgaaTTTGTTATAATGTTTAAATGgtaacaaacgaatggag g" /listShort="pcrB, pcrA, ligA, yerH, S234, yerI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 668199..668885 /gene="pcrB" /locus_tag="BSU_06600" /old_locus_tag="BSU06600" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16377641, 21761520, 21214173, 27226549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16377641, 21761520, 21214173, 27226549; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="heptaprenylglyceryl-phosphate synthase" /protein_id="NP_388542.1" /db_xref="EnsemblGenomes-Gn:BSU06600" /db_xref="EnsemblGenomes-Tr:CAB12480" /db_xref="GOA:O34790" /db_xref="InterPro:IPR008205" /db_xref="PDB:1VIZ" /db_xref="PDB:3VZX" /db_xref="PDB:3VZY" /db_xref="PDB:3VZZ" /db_xref="PDB:3W00" /db_xref="SubtiList:BG12833" /db_xref="UniProtKB/Swiss-Prot:O34790" /translation="MYDVTEWKHVFKLDPNKDLPDEQLEILCESGTDAVIIGGSDGVT EDNVLRMMSKVRRFLVPCVLEVSAIEAIVPGFDLYFIPSVLNSKNADWIVGMHQKAMK EYGELMSMEEIVAEGYCIANPDCKAAALTEADADLNMDDIVAYARVSELLQLPIFYLE YSGVLGDIEAVKKTKAVLETSTLFYGGGIKDAETAKQYAEHADVIVVGNAVYEDFDRA LKTVAAVKGE*" /label="pcrB CDS" gene 668199..668885 /gene="pcrB" /locus_tag="BSU_06600" /old_locus_tag="BSU06600" /label="pcrB gene" CDS 668947..671166 /gene="pcrA" /locus_tag="BSU_06610" /old_locus_tag="BSU06610" /EC_number="3.6.4.12" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12073041, 12682299, 14594837, 16267290, 26070154; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent DNA helicase" /protein_id="NP_388543.1" /db_xref="EnsemblGenomes-Gn:BSU06610" /db_xref="EnsemblGenomes-Tr:CAB12481" /db_xref="GOA:O34580" /db_xref="InterPro:IPR000212" /db_xref="InterPro:IPR005751" /db_xref="InterPro:IPR014016" /db_xref="InterPro:IPR014017" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR034739" /db_xref="SubtiList:BG12834" /db_xref="UniProtKB/Swiss-Prot:O34580" /translation="MNYISNQLLSGLNPVQQEAVKTTDGPLLLMAGAGSGKTRVLTHR IAYLMAEKHVAPWNILAITFTNKAAREMKERVESILGPGADDIWISTFHSMCVRILRR DIDRIGINRNFSILDTADQLSVIKGILKERNLDPKKFDPRSILGTISSAKNELTEPEE FSKVAGGYYDQVVSDVYADYQKKLLKNQSLDFDDLIMTTIKLFDRVPEVLEFYQRKFQ YIHVDEYQDTNRAQYMLVKQLAERFQNLCVVGDSDQSIYRWRGADITNILSFEKDYPN ASVILLEQNYRSTKRILRAANEVIKNNSNRKPKNLWTENDEGIKISYYRGDNEFGEGQ FVAGKIHQLHSTGKRKLSDIAILYRTNAQSRVIEETLLKAGLNYNIVGGTKFYDRKEI KDILAYLRLVSNPDDDISFTRIVNVPKRGVGATSLEKIASYAAINGLSFFQAIQQVDF IGVSAKAANALDSFRQMIENLTNMQDYLSITELTEEILDKTEYREMLKAEKSIEAQSR LENIDEFLSVTKNFEQKSEDKTLVAFLTDLALIADIDQLDQKEEESGGKDAITLMTLH AAKGLEFPVVFLMGLEEGVFPHSRSLMEEAEMEEERRLAYVGITRAEQELYLTNAKMR TLFGRTNMNPESRFIAEIPDDLLENLNEKKETRATSARKMQPRRGPVSRPVSYASKTG GDTLNWAVGDKAGHKKWGTGTVVSVKGEGEGTELDIAFPSPVGVKRLLAAFAPIEKQ* " /label="pcrA CDS" gene 668947..671166 /gene="pcrA" /locus_tag="BSU_06610" /old_locus_tag="BSU06610" /label="pcrA gene" CDS 671190..673196 /gene="ligA" /locus_tag="BSU_06620" /old_locus_tag="BSU06620" /EC_number="6.5.1.2" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:164915, 11095673, 12682299, 16267290" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 164915, 11095673, 12682299, 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA ligase (NAD-dependent)" /protein_id="NP_388544.1" /db_xref="EnsemblGenomes-Gn:BSU06620" /db_xref="EnsemblGenomes-Tr:CAB12482" /db_xref="GOA:O31498" /db_xref="InterPro:IPR001357" /db_xref="InterPro:IPR001679" /db_xref="InterPro:IPR003583" /db_xref="InterPro:IPR004149" /db_xref="InterPro:IPR004150" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR013839" /db_xref="InterPro:IPR013840" /db_xref="InterPro:IPR018239" /db_xref="InterPro:IPR033136" /db_xref="InterPro:IPR036420" /db_xref="SubtiList:BG12835" /db_xref="UniProtKB/Swiss-Prot:O31498" /translation="MDKETAKQRAEELRRTINKYSYEYYTLDEPSVPDAEYDRLMQEL IAIEEEHPDLRTPDSPTQRVGGAVLEAFQKVTHGTPMLSLGNAFNADDLRDFDRRVRQ SVGDDVAYNVELKIDGLAVSLRYEDGYFVRGATRGDGTTGEDITENLKTIRNIPLKMN RELSIEVRGEAYMPKRSFEALNEERIKNEEEPFANPRNAAAGSLRQLDPKIAAKRNLD IFVYSIAELDEMGVETQSQGLDFLDELGFKTNQERKKCGSIEEVITLIDELQAKRADL PYEIDGIVIKVDSLDQQEELGFTAKSPRWAIAYKFPAEEVVTKLLDIELNVGRTGVIT PTAILEPVKVAGTTVSRASLHNEDLIKEKDIRILDKVVVKKAGDIIPEVVNVLVDQRT GEEKEFSMPTECPECGSELVRIEGEVALRCINPECPAQIREGLIHFVSRNAMNIDGLG ERVITQLFEENLVRNVADLYKLTKERVIQLERMGEKSTENLISSIQKSKENSLERLLF GLGIRFIGSKAAKTLAMHFESLENLKKASKEELLAVDEIGEKMADAVITYFHKEEMLE LLNELQELGVNTLYKGPKKVKAEDSDSYFAGKTIVLTGKLEELSRNEAKAQIEALGGK LTGSVSKNTDLVIAGEAAGSKLTKAQELNIEVWNEEQLMGELKK*" /label="ligA CDS" gene 671190..673196 /gene="ligA" /locus_tag="BSU_06620" /old_locus_tag="BSU06620" /label="ligA gene" CDS 673212..674402 /gene="yerH" /locus_tag="BSU_06630" /old_locus_tag="BSU06630" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16267290; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_388545.1" /db_xref="EnsemblGenomes-Gn:BSU06630" /db_xref="EnsemblGenomes-Tr:CAB12483" /db_xref="GOA:O34629" /db_xref="InterPro:IPR011426" /db_xref="SubtiList:BG12836" /db_xref="UniProtKB/Swiss-Prot:O34629" /translation="MKKTLALAATAAVLMLSACSSGFGGEKEEEITQKTAKSSEKAIV PKYNISDSYYKMVLPFKAGKARGLTTEQLNTRLDIDEFETGLMRLAQDSFSTDDYLFQ EGQYLDEDTVLSWLARKKTGSDLKKAEKEDKNFKNEGLNPALPSSGSTEEKNESSPIY LASMLEHDYLVRKDKNSIQLGGVMIGLALNSVYYYREKTGDPQKEVEIKDSTLRQQGE KIAQEVINRLRKKDNLKNVPITVALYKQASKTSIVPGNFIAKTEVKAGSTDISNWDDI NEKYVFYPADTTTAEKYPDDTEVFKRFKNSIEEYFPNYTGVVGTALYENDEMKKMKID IPMQFYGKSEVVAFTQFLTGEVMDYYSKSSVDVEVNITSSDGQEAVIIRNAGDKEPTV HIYD*" /label="yerH CDS" gene 673212..674402 /gene="yerH" /locus_tag="BSU_06630" /old_locus_tag="BSU06630" /label="yerH gene" misc_feature complement(673407..673411) /Source="Nicolas_upshift_promotors" /id="U508" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.986013986013986" /psig="0.000999000999001" /xcortree=36 /SigmaFactorBS="atcagccctgtttcaaattcgtcaatgtccagccttgtattc agctgttccgttgttaagCCGCGcgctttgcctgccttaaacggcagcaccattttgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(673411) /Source="Nicolas_upshifts" /id="U508" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.986013986013986" /psig="0.000999000999001" /xcortree=36 /SigmaFactorBS="atcagccctgtttcaaattcgtcaatgtccagccttgtattc agctgttccgttgttaagCCGCGcgctttgcctgccttaaacggcagcaccattttgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 674439..674458 /Source="Nicolas_upshift_promotors" /id="U509" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=3168 /SigmaFactorBS="tcacatttatgactgatagaaaacccttgtgccatattggca caagggttttTATGTTACAATTAACAGGAAaagggaaaatattttcacttctgccgaa a" /listShort="S234, yerI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 674447..674563 /Source="Nicolas_S_feature" /locus_tag="new_724870_724986" /HighExp="LoTm, B60, Lbstat, B36, BI, M9-stat, T1.30H, ferm, T3.30H, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S234" upshifts 674447 /Source="Nicolas_upshifts" /id="U509" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=3168 /SigmaFactorBS="tcacatttatgactgatagaaaacccttgtgccatattggca caagggttttTATGTTACAATTAACAGGAAaagggaaaatattttcacttctgccgaa a" /listShort="S234, yerI" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(674511) /Source="Nicolas_upshifts" /id="D327" /incds=0 /nref=2 /ntot=118 /MaxReadThrough="1.21197" /MaxDrop="3.77048" /score="18.5253059" /energy="-17.7" /TU="NA" /idTUdmin="U511" /TUdmin=1122 /isTUend="FALSE" /label="downshifts" CDS 674564..675574 /gene="yerI" /locus_tag="BSU_06640" /old_locus_tag="BSU06640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative kinase" /protein_id="NP_388546.1" /db_xref="EnsemblGenomes-Gn:BSU06640" /db_xref="EnsemblGenomes-Tr:CAB12484" /db_xref="InterPro:IPR002575" /db_xref="InterPro:IPR011009" /db_xref="SubtiList:BG12837" /db_xref="UniProtKB/Swiss-Prot:O34640" /translation="MLDVHKDIKKIFHEEQVLAEAAARYGFSKDQVRFLADAENYVYE CMKDNQPYILKITHTIRRSSDYMMGEMEWLRHLAIGGISVAKPLPSLNGKDVEAVPDG NGGSFLLRVYEKAPGQKVDESDWNETLFYELGRYTGSMHSLTKSYKLSNPAFKRQEWD EEEQLKLRKYVPEDQIKVFQQADSLMNELRRLPKSQDNYGLVHADLHHGNFNWDHGKI TAFDFDDIGYNWFVNDISILLYNVLWYPVVPYDDKAAFTEEFMTHFMKGYWEENELDP AWLMIIPDFLRLRHMLIYGLLHQMFDLNTIGEEEKEMLAGFRRDIENGTPITAFDFSA LV*" /label="yerI CDS" gene 674564..675574 /gene="yerI" /locus_tag="BSU_06640" /old_locus_tag="BSU06640" /label="yerI gene" promotor_no_box complement(674581..674681) /Source="Nicolas_upshift_promotors" /id="U510" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.993006993006993" /psig=0 /xcortree=53 /SigmaFactorBS="tttccgcatcagccagaaaacgcacctgatcttttgagaaac cgtatctcgctgcagcttctgccaaaacctgctcttcatgaaatatttttttgatatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(674621) /Source="Nicolas_upshifts" /id="U510" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.993006993006993" /psig=0 /xcortree=53 /SigmaFactorBS="tttccgcatcagccagaaaacgcacctgatcttttgagaaac cgtatctcgctgcagcttctgccaaaacctgctcttcatgaaatatttttttgatatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 675557 /Source="Nicolas_upshifts" /id="D328" /incds=0 /nref=137 /ntot=253 /MaxReadThrough="3.07041" /MaxDrop="5.10987" /score="12.7441524" /energy="-17" /TU="NA" /idTUdmin="U507" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 675601..676405 /Source="Nicolas_S_feature" /locus_tag="new_726024_726828" /HighExp="B60, B36, LoTm, M9-stat, Cold, T1.30H, T0.30H, ferm, Lbstat, LBGstat" /AntisenseName="sapB" /AntisenseCor="-0.57665624439942198" /AntisenseRegPval="-24.5" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S235" CDS complement(675612..676310) /gene="sapB" /locus_tag="BSU_06650" /old_locus_tag="BSU06650" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 410907, 9043134, 14708580, 27350030, 28181542; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative magnesium transporter" /protein_id="NP_388547.1" /db_xref="EnsemblGenomes-Gn:BSU06650" /db_xref="EnsemblGenomes-Tr:CAB12485" /db_xref="GOA:Q45514" /db_xref="InterPro:IPR003416" /db_xref="SubtiList:BG11845" /db_xref="UniProtKB/Swiss-Prot:Q45514" /translation="MLLSWYIDPDILLKLGIATLIGMVIGLERELKNKPLGLKTCIVI AVSSCMLTIVSINAAYHFPKYYRIMMDPLRLPAQIISGVGFIGAGVILRKSNDVISGL TTSAMIWGAAGLGLATGAGFYKEAFASLLFILISVEFLPWVVRKIGPDRLQEKDIRIR MSLSDKDKMTEILKEMKRRDIKAHSVRIDDLGEKDFPIMEVKVRVHKNRYTTDVYYDI KAIEGVVGVKCDTL*" /label="sapB CDS" gene complement(675612..676310) /gene="sapB" /locus_tag="BSU_06650" /old_locus_tag="BSU06650" /label="sapB gene" downshifts complement(675633) /Source="Nicolas_upshifts" /id="D329" /incds=0 /nref=26 /ntot=129 /MaxReadThrough="2.5379" /MaxDrop="3.83708" /score="20.8493264" /energy="-16.2" /TU="NA" /idTUdmin="U511" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(676330..676348) /Source="Nicolas_upshift_promotors" /id="U511" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.684315684315684" /psig="0.684315684315684" /xcortree=1465 /SigmaFactorBS="aagccatcaagcgcagcttggtggcttttgtgctcttgtttt GCTATAaatactgtgagaaaaTCATATTTATTTAAAAACAccatagagaagggggaag t" /listShort="sapB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(676351) /Source="Nicolas_upshifts" /id="U511" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.684315684315684" /psig="0.684315684315684" /xcortree=1465 /SigmaFactorBS="aagccatcaagcgcagcttggtggcttttgtgctcttgtttt GCTATAaatactgtgagaaaaTCATATTTATTTAAAAACAccatagagaagggggaag t" /listShort="sapB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(676364..676369) /Source="Nicolas_upshift_promotors" /id="U511" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.684315684315684" /psig="0.684315684315684" /xcortree=1465 /SigmaFactorBS="aagccatcaagcgcagcttggtggcttttgtgctcttgtttt GCTATAaatactgtgagaaaaTCATATTTATTTAAAAACAccatagagaagggggaag t" /listShort="sapB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(676417..677895) /gene="opuE" /locus_tag="BSU_06660" /old_locus_tag="BSU06660" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9701821, 11902719, 14996799, 15849754, 16850406, 17183215, 22685134" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9701821, 11902719, 14996799, 15849754, 16850406, 17183215, 22685134; Product type t: transporter" /codon_start=1 /transl_table=11 /product="proline transporter" /protein_id="NP_388548.1" /db_xref="EnsemblGenomes-Gn:BSU06660" /db_xref="EnsemblGenomes-Tr:CAB12486" /db_xref="GOA:O06493" /db_xref="InterPro:IPR001734" /db_xref="InterPro:IPR011851" /db_xref="InterPro:IPR018212" /db_xref="SubtiList:BG12641" /db_xref="UniProtKB/Swiss-Prot:O06493" /translation="MSIEIIISLGIYFIAMLLIGWYAFKKTTDINDYMLGGRGLGPFV TALSAGAADMSGWMLMGVPGAMFATGLSTLWLALGLTIGAYSNYLLLAPRLRAYTEAA DDAITIPDFFDKRFQHSSSLLKIVSALIIMIFFTLYTSSGMVSGGRLFESAFGADYKL GLFLTTAVVVLYTLFGGFLAVSLTDFVQGAIMFAALVLVPIVAFTHVGGVAPTFHEID AVNPHLLDIFKGASVISIISYLAWGLGYYGQPHIIVRFMAIKDIKDLKPARRIGMSWM IITVLGSVLTGLIGVAYAHKFGVAVKDPEMIFIIFSKILFHPLITGFLLSAILAAIMS SISSQLLVTASAVTEDLYRSFFRRKASDKELVMIGRLSVLVIAVIAVLLSLNPNSTIL DLVGYAWAGFGSAFGPAILLSLYWKRMNEWGALAAMIVGAATVLIWITTGLAKSTGVY EIIPGFILSMIAGIIVSMITKRPAKASYRLFGVMEKLLKRKK*" /label="opuE CDS" gene complement(676417..677895) /gene="opuE" /locus_tag="BSU_06660" /old_locus_tag="BSU06660" /label="opuE gene" downshifts complement(676431) /Source="Nicolas_upshifts" /id="D330" /incds=0 /nref=43 /ntot=142 /MaxReadThrough="5.35634" /MaxDrop="4.34381" /score="9.43100511" /energy="-13.8" /TU="U512,U513" /idTUdmin="U511" /TUdmin="-798" /isTUend="FALSE" /label="downshifts" upshifts complement(677283) /Source="Nicolas_upshifts" /id="U512" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.475524475524476" /psig="0.475524475524476" /xcortree=138 /SigmaFactorBS="gacttcgtgcagggtgcgatcatgtttgcagcactagtgctt gtGCCGATCGTTGCTTttacccatgtgggcggcgttgctccgactttccatgaaatcg a" /listShort="sapB" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(677286..677299) /Source="Nicolas_upshift_promotors" /id="U512" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.475524475524476" /psig="0.475524475524476" /xcortree=138 /SigmaFactorBS="gacttcgtgcagggtgcgatcatgtttgcagcactagtgctt gtGCCGATCGTTGCTTttacccatgtgggcggcgttgctccgactttccatgaaatcg a" /listShort="sapB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature complement(677896..678026) /Source="Nicolas_S_feature" /locus_tag="new_728319_728449_c" /HighExp="Salt, HiOs, Etha, Gly, MG 25, MG 45, M9-exp, MG t5, MG 15, GM 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.954" /TUlongSig="NA" /TUlongPSig="NA" /label="S236" promotor_-10 complement(678017..678035) /Source="Nicolas_upshift_promotors" /id="U513" /multdbtbs="SigA,SigB" /comp="M11" /sig="SigB" /pcomp="0.954045954045954" /psig="0.954045954045954" /xcortree=137 /SigmaFactorBS="tttgcaacggtatttccagcttatgatcaaTGTTTCAtcgct tgaatggccGGGAATACTTTGTTAGGTTaagttaccaagtgcacccgcaaaagaattt c" /listShort="S236, opuE, sapB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(678026) /Source="Nicolas_upshifts" /id="U513" /multdbtbs="SigA,SigB" /comp="M11" /sig="SigB" /pcomp="0.954045954045954" /psig="0.954045954045954" /xcortree=137 /SigmaFactorBS="tttgcaacggtatttccagcttatgatcaaTGTTTCAtcgct tgaatggccGGGAATACTTTGTTAGGTTaagttaccaagtgcacccgcaaaagaattt c" /listShort="S236, opuE, sapB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(678050..678056) /Source="Nicolas_upshift_promotors" /id="U513" /multdbtbs="SigA,SigB" /comp="M11" /sig="SigB" /pcomp="0.954045954045954" /psig="0.954045954045954" /xcortree=137 /SigmaFactorBS="tttgcaacggtatttccagcttatgatcaaTGTTTCAtcgct tgaatggccGGGAATACTTTGTTAGGTTaagttaccaagtgcacccgcaaaagaattt c" /listShort="S236, opuE, sapB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 678157..678160 /Source="Nicolas_upshift_promotors" /id="U514" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.88011988011988" /psig="0.999000999001" /xcortree=2562 /SigmaFactorBS="ttcaaaaaataattaaagtaaaaatattcagaaaaatatttc GTTTctccttctcctcatttTAGTATAAAATATATAGGGTattgtttcgaaaacacag g" /listShort="S237, gatC, gatA, gatB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 678175..678308 /Source="Nicolas_S_feature" /locus_tag="new_728598_728731" /HighExp="G180, G150, LBGexp, Oxctl, Paraq, dia0, G135, Lbexp, H2O2, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S237" upshifts 678175 /Source="Nicolas_upshifts" /id="U514" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.88011988011988" /psig="0.999000999001" /xcortree=2562 /SigmaFactorBS="ttcaaaaaataattaaagtaaaaatattcagaaaaatatttc GTTTctccttctcctcatttTAGTATAAAATATATAGGGTattgtttcgaaaacacag g" /listShort="S237, gatC, gatA, gatB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 678177..678196 /Source="Nicolas_upshift_promotors" /id="U514" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.88011988011988" /psig="0.999000999001" /xcortree=2562 /SigmaFactorBS="ttcaaaaaataattaaagtaaaaatattcagaaaaatatttc GTTTctccttctcctcatttTAGTATAAAATATATAGGGTattgtttcgaaaacacag g" /listShort="S237, gatC, gatA, gatB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 678309..678599 /gene="gatC" /locus_tag="BSU_06670" /old_locus_tag="BSU06670" /EC_number="6.3.5.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9342321, 11445070, 12682299, 25005615" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9342321, 11445070, 12682299, 25005615; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamyl-tRNA(Gln) amidotransferase (subunit C)" /protein_id="NP_388549.1" /db_xref="EnsemblGenomes-Gn:BSU06670" /db_xref="EnsemblGenomes-Tr:CAB12487" /db_xref="GOA:O06492" /db_xref="InterPro:IPR003837" /db_xref="InterPro:IPR036113" /db_xref="SubtiList:BG12838" /db_xref="UniProtKB/Swiss-Prot:O06492" /translation="MSRISIEEVKHVAHLARLAITEEEAKMFTEQLDSIISFAEELNE VNTDNVEPTTHVLKMKNVMREDEAGKGLPVEDVMKNAPDHKDGYIRVPSILD*" /label="gatC CDS" gene 678309..678599 /gene="gatC" /locus_tag="BSU_06670" /old_locus_tag="BSU06670" /label="gatC gene" CDS 678615..680072 /gene="gatA" /locus_tag="BSU_06680" /old_locus_tag="BSU06680" /EC_number="6.3.5.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11445070, 12682299, 9342321" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11445070, 12682299, 9342321; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamyl-tRNA(Gln) amidotransferase (subunit A)" /protein_id="NP_388550.1" /db_xref="EnsemblGenomes-Gn:BSU06680" /db_xref="EnsemblGenomes-Tr:CAB12488" /db_xref="GOA:O06491" /db_xref="InterPro:IPR000120" /db_xref="InterPro:IPR004412" /db_xref="InterPro:IPR020556" /db_xref="InterPro:IPR023631" /db_xref="InterPro:IPR036928" /db_xref="SubtiList:BG12839" /db_xref="UniProtKB/Swiss-Prot:O06491" /translation="MSLFDHKITELKQLIHKKEIKISDLVDESYKRIQAVDDKVQAFL ALDEERARAYAKELDEAVDGRSEHGLLFGMPIGVKDNIVTKGLRTTCSSKILENFDPI YDATVVQRLQDAEAVTIGKLNMDEFAMGSSTENSAYKLTKNPWNLDTVPGGSSGGSAA AVAAGEVPFSLGSDTGGSIRQPASFCGVVGLKPTYGRVSRYGLVAFASSLDQIGPITR TVEDNAFLLQAISGVDKMDSTSANVDVPDFLSSLTGDIKGLKIAVPKEYLGEGVGKEA RESVLAALKVLEGLGATWEEVSLPHSKYALATYYLLSSSEASANLARFDGIRYGYRTD NADNLIDLYKQTRAEGFGNEVKRRIMLGTFALSSGYYDAYYKKAQKVRTLIKKDFEDV FEKYDVIVGPTTPTPAFKIGENTKDPLTMYANDILTIPVNLAGVPGISVPCGLADGLP LGLQIIGKHFDESTVYRVAHAFEQATDHHKAKPEL*" /label="gatA CDS" gene 678615..680072 /gene="gatA" /locus_tag="BSU_06680" /old_locus_tag="BSU06680" /label="gatA gene" CDS 680086..681516 /gene="gatB" /locus_tag="BSU_06690" /old_locus_tag="BSU06690" /EC_number="6.3.5.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11445070, 12682299, 9342321" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11445070, 12682299, 9342321; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamyl-tRNA(Gln) amidotransferase (subunit B)" /protein_id="NP_388551.2" /db_xref="EnsemblGenomes-Gn:BSU06690" /db_xref="EnsemblGenomes-Tr:CAB12489" /db_xref="GOA:O30509" /db_xref="InterPro:IPR003789" /db_xref="InterPro:IPR004413" /db_xref="InterPro:IPR006075" /db_xref="InterPro:IPR014746" /db_xref="InterPro:IPR017958" /db_xref="InterPro:IPR017959" /db_xref="InterPro:IPR018027" /db_xref="InterPro:IPR023168" /db_xref="SubtiList:BG12840" /db_xref="UniProtKB/Swiss-Prot:O30509" /translation="MNFETVIGLEVHVELKTKSKIFSSSPTPFGAEANTQTSVIDLGY PGVLPVLNKEAVEFAMKAAMALNCEIATDTKFDRKNYFYPDNPKAYQISQFDKPIGEN GWIEIEVGGKTKRIGITRLHLEEDAGKLTHTGDGYSLVDFNRQGTPLVEIVSEPDIRT PEEAYAYLEKLKSIIQYTGVSDCKMEEGSLRCDANISLRPIGQEEFGTKTELKNLNSF AFVQKGLEHEEKRQEQVLLSGGVIQQETRRYDEATKKTILMRVKEGSDDYRYFPEPDL VELYIDDEWKERVKASIPELPDERRKRYIEELGLPAYDAMVLTLTKEMADFFEETVQK GAEAKQASNWLMGEVSAYLNAEQKELADVALTPEGLAGMIKLIEKGTISSKIAKKVFK ELIEKGGDAEKIVKEKGLVQISDEGVLLKLVTEALDNNPQSIEDFKNGKDRAIGFLVG QIMKASKGQANPPMVNKILLEEIKKR*" /label="gatB CDS" gene 680086..681516 /gene="gatB" /locus_tag="BSU_06690" /old_locus_tag="BSU06690" /label="gatB gene" downshifts 681497 /Source="Nicolas_upshifts" /id="D331" /incds=0 /nref=257 /ntot=266 /MaxReadThrough="1.62334" /MaxDrop="8.77378" /score="26.1218607" /energy="-9.6" /TU="NA" /idTUdmin="U514" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(681531..682400) /gene="yerO" /locus_tag="BSU_06700" /old_locus_tag="BSU06700" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (TetR/AcrR family)" /protein_id="NP_388552.1" /db_xref="EnsemblGenomes-Gn:BSU06700" /db_xref="EnsemblGenomes-Tr:CAB12490" /db_xref="GOA:O31500" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR023772" /db_xref="SubtiList:BG12841" /db_xref="UniProtKB/Swiss-Prot:O31500" /translation="MNEKKERIIKTSIRLFAKKGFAATTIQEIASECGISKGAFYLHF KSKEALLLSACEYYIGMSMNKMKNIEEDLAGKPPKEVLKKQIGAQFEDFRDHKDFIVL LLTENIIPENQEIKQYFYKVTMETDKLYRNALLVSYGEGIERYVADLSIMARGIVHSY MNVMVFNGELNIDAEEISAFIIERLDDLVQGLSRSALNPIVSKDIFNPMPAGKDQLLE DIQKVKENSTLPEDITVSLDVIEEELTQDKPRKPIIKGMLSNLAGTNDKEVERLRALI LSLSQFDHKKSSL*" /label="yerO CDS" gene complement(681531..682400) /gene="yerO" /locus_tag="BSU_06700" /old_locus_tag="BSU06700" /label="yerO gene" downshifts complement(681573) /Source="Nicolas_upshifts" /id="D332" /incds=0 /nref=122 /ntot=211 /MaxReadThrough="2.21801" /MaxDrop="4.89305" /score="32.2694333" /energy="-11.4" /TU="NA" /idTUdmin="U517" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 682190..682195 /Source="Nicolas_upshift_promotors" /id="U515" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.822177822177822" /psig="0.822177822177822" /xcortree=1398 /SigmaFactorBS="ccttaggcggctttccggcgagatcttCTTCTAtatttttca ttttgtTCATAGACATACCGATATAatattcacaggcagataacagcagcgcttcttt c" /GFF_Attribute="listShort" /listLong="swrC" /label="promotor_-35" promotor_-10 682211..682229 /Source="Nicolas_upshift_promotors" /id="U515" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.822177822177822" /psig="0.822177822177822" /xcortree=1398 /SigmaFactorBS="ccttaggcggctttccggcgagatcttCTTCTAtatttttca ttttgtTCATAGACATACCGATATAatattcacaggcagataacagcagcgcttcttt c" /GFF_Attribute="listShort" /listLong="swrC" /label="promotor_-10" upshifts 682223 /Source="Nicolas_upshifts" /id="U515" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.822177822177822" /psig="0.822177822177822" /xcortree=1398 /SigmaFactorBS="ccttaggcggctttccggcgagatcttCTTCTAtatttttca ttttgtTCATAGACATACCGATATAatattcacaggcagataacagcagcgcttcttt c" /GFF_Attribute="listShort" /listLong="swrC" /label="upshifts" S_feature complement(682401..682475) /Source="Nicolas_S_feature" /locus_tag="new_732824_732898_c" /HighExp="C30, S1, T3.0H, T4.0H, Salt, T5.0H, T2.0H, T3.30H, MG 150, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S238" promotor_-35 682453..682460 /Source="Nicolas_upshift_promotors" /id="U516" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.679320679320679" /psig="0.998001998001998" /xcortree=3014 /SigmaFactorBS="taatccttgaaaaatttagtaaaattttctggtatatgAGTT GACGttgttgcgttataacGTTTAGTATTATATAGAATGaccagtcagtcaataaaaa a" /listShort="swrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(682469..682488) /Source="Nicolas_upshift_promotors" /id="U517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3036 /SigmaFactorBS="acgtggttcatcatatcctccattacatttttTATTGACTga ctggtcattctaTATAATACTAAACGTTATAAcgcaacaacgtcaactcatataccag a" /listShort="S238, yerO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 682475 /Source="Nicolas_upshifts" /id="U516" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.679320679320679" /psig="0.998001998001998" /xcortree=3014 /SigmaFactorBS="taatccttgaaaaatttagtaaaattttctggtatatgAGTT GACGttgttgcgttataacGTTTAGTATTATATAGAATGaccagtcagtcaataaaaa a" /listShort="swrC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 682476..682495 /Source="Nicolas_upshift_promotors" /id="U516" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.679320679320679" /psig="0.998001998001998" /xcortree=3014 /SigmaFactorBS="taatccttgaaaaatttagtaaaattttctggtatatgAGTT GACGttgttgcgttataacGTTTAGTATTATATAGAATGaccagtcagtcaataaaaa a" /listShort="swrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(682482) /Source="Nicolas_upshifts" /id="U517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3036 /SigmaFactorBS="acgtggttcatcatatcctccattacatttttTATTGACTga ctggtcattctaTATAATACTAAACGTTATAAcgcaacaacgtcaactcatataccag a" /listShort="S238, yerO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(682503..682510) /Source="Nicolas_upshift_promotors" /id="U517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3036 /SigmaFactorBS="acgtggttcatcatatcctccattacatttttTATTGACTga ctggtcattctaTATAATACTAAACGTTATAAcgcaacaacgtcaactcatataccag a" /listShort="S238, yerO" /GFF_Attribute="listLong" /label="promotor_-35" CDS 682532..685690 /gene="srfP" /locus_tag="BSU_06710" /old_locus_tag="BSU06710" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11709341, 15066026, 15941986, 25366377" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11709341, 15066026, 15941986, 25366377; Product type t: transporter" /codon_start=1 /transl_table=11 /product="surfactin exporter involved in surfactin self-resistance" /protein_id="NP_388553.2" /db_xref="EnsemblGenomes-Gn:BSU06710" /db_xref="EnsemblGenomes-Tr:CAB12491" /db_xref="GOA:O31501" /db_xref="InterPro:IPR001036" /db_xref="InterPro:IPR027463" /db_xref="SubtiList:BG12842" /db_xref="UniProtKB/Swiss-Prot:O31501" /translation="MNHVINFVLKNKFAVWLMTIIVTAAGLYAGMNMKQESIPDVNMP YLTISTTYPGATPSQVADEVTKPVEQAVQNLDGVSVVTSTSYENASSVMIEYDYEKDM DKAKTEAAEALENVNLPDDAKDPEISRYSLNSFPILTLSVSSDKDNLQELTKQVEDSL VSKLEGIEGVASVQVSGQQVEEVEFSFKEDKLKEYGLDEDTVKQVIQGSDVTTPLGLY TFGNEEKSVVVSGDIETIKDLKNMRIPTASASSAGSSAASQAGAQSAQAAQSAQAAAQ VQQSASTAVPTVKLSDIATIKDVKKAESVSRTNGKDSIGINIVKANDANTVEVADDVK AELKKFKEDHKGFNYSATLDMAEPITQSVDTMLSKAIFGAIFAIVIILLFLRDIKSTL ISVVSIPLSLLIALLVLQQLDITLNIMTLGAMTVAIGRVVDDSIVVIENIYRRMRLKD EPLRGKALVREATKEMFKPIMSSTIVTIAVFLPLALVGGQIGELFIPFALTIVFALAA SLVISITLVPMLAHSLFKKSLTGAPIKAKEHKPGRLANIYKKVLNWALSHKWITSIIA VLMLLGSLFLVPLIGASYLPSEEEKTMQLTYSPEPGETKKEAENEAEKAEKILLDRKH VDTVQYSLGSGSPLAGGDSNGALFYIKYESDTPDFDKEKDNVLKEIQKQSDRGEWKSQ DFSSSGNNNELTYYVYGDSENDIKDTVKDIEKIMKDEKDLKNVNSGLSSTYDEYTFVA DQEKLSKLGLTASQISQALMSQTSQEPLTTVKKDGKELDVNIKTEKDEYKSVKDLENK KITSATGQEVKIGDVAKVKEGSTSDTVSKRDGKVYADVTGEVTSDNVTAVSAAIQKKI DKLDHPDNVSIDTGGVSADIADSFTKLGLAMLAAIAIVYLVLVITFGGALAPFAILFS LPFTVIGALVGLYVSGETISLNAMIGMLMLIGIVVTNAIVLIDRVIHKEAEGLSTREA LLEAGSTRLRPILMTAIATIGALIPLALGFEGGSQVISKGLGVTVIGGLISSTLLTLL IVPIVYEVLAKFRKKKPGTEEE*" /label="srfP CDS" gene 682532..685690 /gene="srfP" /locus_tag="BSU_06710" /old_locus_tag="BSU06710" /label="srfP gene" downshifts 685677 /Source="Nicolas_upshifts" /id="D333" /incds=0 /nref=76 /ntot=243 /MaxReadThrough="3.70478" /MaxDrop="4.6624" /score="-3.65521193" /energy="-12.7" /TU="U516" /idTUdmin="U516" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" promotor_-35 685929..685932 /Source="Nicolas_upshift_promotors" /id="U518" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.758241758241758" /psig="0.999000999001" /xcortree=2594 /SigmaFactorBS="tgtgcgttttcacctgtaagattatgtacattttGTTGcgat ttttttaactCATAGTATAATTAAAGGTTGttagtgtaaaaatggatcggatactctt a" /listShort="dagK, S239, yefA, S240, S241, yefC, S242, yeeA, yeeB, S243, yeeC, S244" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 685947..685966 /Source="Nicolas_upshift_promotors" /id="U518" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.758241758241758" /psig="0.999000999001" /xcortree=2594 /SigmaFactorBS="tgtgcgttttcacctgtaagattatgtacattttGTTGcgat ttttttaactCATAGTATAATTAAAGGTTGttagtgtaaaaatggatcggatactctt a" /listShort="dagK, S239, yefA, S240, S241, yefC, S242, yeeA, yeeB, S243, yeeC, S244" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 685955 /Source="Nicolas_upshifts" /id="U518" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.758241758241758" /psig="0.999000999001" /xcortree=2594 /SigmaFactorBS="tgtgcgttttcacctgtaagattatgtacattttGTTGcgat ttttttaactCATAGTATAATTAAAGGTTGttagtgtaaaaatggatcggatactctt a" /listShort="dagK, S239, yefA, S240, S241, yefC, S242, yeeA, yeeB, S243, yeeC, S244" /GFF_Attribute="listLong" /label="upshifts" CDS 686013..686924 /gene="dagK" /locus_tag="BSU_06720" /old_locus_tag="BSU06720" /EC_number="2.7.1.107" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10220166, 12682299, 17535816, 22224599, 24700682" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10220166, 12682299, 17535816, 22224599, 24700682; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="diacylglycerol kinase" /protein_id="NP_388554.1" /db_xref="EnsemblGenomes-Gn:BSU06720" /db_xref="EnsemblGenomes-Tr:CAB12492" /db_xref="GOA:O31502" /db_xref="InterPro:IPR001206" /db_xref="InterPro:IPR005218" /db_xref="InterPro:IPR016064" /db_xref="InterPro:IPR017438" /db_xref="SubtiList:BG12843" /db_xref="UniProtKB/Swiss-Prot:O31502" /translation="MKRARIIYNPTSGREIFKKHLAQVLQKFEQAGYETSTHATTCAG DATHAAKEAALREFDLIIAAGGDGTINEVVNGLAPLDNRPTLGVIPVGTTNDFARALG IPREDILKAADTVINGVARPIDIGQVNGQYFINIAGGGRLTELTYDVPSKLKTMLGQL AYYLKGMEMLPSLRPTEVEIEYDGKLFQGEIMLFLVTLTNSVGGFEKLAPDSSLNDGM FDLMILKKANLAEFIRVATMALRGEHINDQHIIYTKANRVKVNVSEKMQLNLDGEYGG MLPGEFVNLYRHIHVVMPKEKAEQLDD*" /label="dagK CDS" gene 686013..686924 /gene="dagK" /locus_tag="BSU_06720" /old_locus_tag="BSU06720" /label="dagK gene" S_feature 686925..687179 /Source="Nicolas_S_feature" /locus_tag="new_737348_737602" /HighExp="H2O2, Oxctl, Paraq, G180, Cold, C30, G150, G135, Heat, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S239" CDS 687180..688559 /gene="rlmCD" /locus_tag="BSU_06730" /old_locus_tag="BSU06730" /EC_number="2.1.1.189" /EC_number="2.1.1.190" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:21824914" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21824914; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methyltransferase of m5U747 and m5U1939 in 23S RNA" /protein_id="NP_388555.1" /db_xref="EnsemblGenomes-Gn:BSU06730" /db_xref="EnsemblGenomes-Tr:CAB12493" /db_xref="GOA:O31503" /db_xref="InterPro:IPR001566" /db_xref="InterPro:IPR002792" /db_xref="InterPro:IPR010280" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR030390" /db_xref="InterPro:IPR030391" /db_xref="SubtiList:BG12826" /db_xref="UniProtKB/Swiss-Prot:O31503" /translation="MKMKPPVEKNEYYDVTFEDLTHEGAGVAKVQGFPIFVPNALPEE KAQIKVTRVKKGFAFGRLIELKEESPHRTDAPCPIYKQCGGCQLQHMTYEGQLLFKQK QVKDVLERIGKLDLSKVTVHPTLGMEDPWNYRNKAQVPVGEREGGLVAGFYQQRSHDI IDMSACLIQQSKNDEAVQAVKDICANYGVKAYNEERHKGWLRHIMVRYGVVTGEMMIV FITRTSDFPHKAKIIEDITAQFPHVKSIVQNINPNKTNVIFGNETNVIWGEEYIYDLI GDVKFAISARSFYQVNPEQTKVLYDKALEYAELQGEETVIDAYCGIGTISLFLAKQAK KVYGVEIVPEAIEDAKRNAELNGNTNAEFAVGEAETVIPKWYEEGITADTLVVDPPRK GCDEALLRTIVEMKPKRVVYVSCNPGTLARDLRVLEDGGYVTREVQPVDMFPHTNHVE CCVLIKLKE*" /label="rlmCD CDS" gene 687180..688559 /gene="rlmCD" /locus_tag="BSU_06730" /old_locus_tag="BSU06730" /label="rlmCD gene" S_feature 688560..689152 /Source="Nicolas_S_feature" /locus_tag="new_738983_739575" /HighExp="Cold, H2O2, G135, G150, Oxctl, G180, C30, Paraq, LPh, HPh" /AntisenseName="yefB" /AntisenseCor="0.24913678485492899" /AntisenseRegPval="-4.4000000000000004" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S240" CDS complement(688572..689474) /gene="yefB" /locus_tag="BSU_06740" /old_locus_tag="BSU06740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 1779754, 1762151; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative site-specific recombinase / invertase; HGT island" /protein_id="NP_388556.1" /db_xref="EnsemblGenomes-Gn:BSU06740" /db_xref="EnsemblGenomes-Tr:CAB12494" /db_xref="GOA:O34574" /db_xref="InterPro:IPR011109" /db_xref="InterPro:IPR025827" /db_xref="SubtiList:BG12827" /db_xref="UniProtKB/Swiss-Prot:O34574" /translation="MYNEGVTSPSQLARKKNATDKWHGSSIRKILENPHYTGTLQQCR EYRPSVTSKRRRSVNLENQIIIEKSHEPIIPLEDFLIVQEILITRKRRRPQAEVHLFT NTAVCKDCRRSMHFKKNRKGYVCGSYNKHGLKACSDHYVSEIDLTDKVITNLNKIYLK FSKENYFKELSEKALKYKEKIESKIIEINEKLNDKKRDKSNLVISLANGVISKEDYQL AINITNEDISNFETTLHQLSKDLEFQKIEKEIIDFKKSLDKFMKEGTLTPEMLHLLVD EIEVHANGTIEINYRFREPTVPSA*" /label="yefB CDS" gene complement(688572..689474) /gene="yefB" /locus_tag="BSU_06740" /old_locus_tag="BSU06740" /label="yefB gene" downshifts 689109 /Source="Nicolas_upshifts" /id="D334" /incds=1 /nref=1 /ntot=30 /MaxReadThrough="4.70474" /MaxDrop="2.82299" /score="-8.81916201" /energy="-8.8" /TU="U518" /idTUdmin="U516" /TUdmin=3322 /isTUend="FALSE" /label="downshifts" S_feature 689154..689454 /Source="Nicolas_S_feature" /locus_tag="new_739577_739877" /HighExp="H2O2, Cold, G180, G135, G150, Paraq, Oxctl, C30, LPh, LBGexp" /AntisenseName="yefB" /AntisenseCor="0.202214664414261" /AntisenseRegPval="-3.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S241" CDS 689455..689790 /gene="yefC" /locus_tag="BSU_06750" /old_locus_tag="BSU06750" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative resolvase; HGT island" /protein_id="NP_388557.2" /db_xref="EnsemblGenomes-Gn:BSU06750" /db_xref="EnsemblGenomes-Tr:CAB12495" /db_xref="GOA:O35034" /db_xref="InterPro:IPR006119" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036162" /db_xref="SubtiList:BG12828" /db_xref="UniProtKB/Swiss-Prot:O35034" /translation="MTPSLYNPLAIASKPFPAIYSEKILIFTIFSAFAEFERDMIVER TQEGKMLAKQNPDFREGRPKKFTKQQINHALTLLENHSYKQVEDMTGISVSTLVRAKK KKAAEAING*" /label="yefC CDS" gene 689455..689790 /gene="yefC" /locus_tag="BSU_06750" /old_locus_tag="BSU06750" /label="yefC gene" S_feature 689791..689864 /Source="Nicolas_S_feature" /locus_tag="new_740214_740287" /HighExp="G180, H2O2, G150, Cold, G135, Paraq, Oxctl, C30, LPh, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S242" CDS 689865..692504 /gene="yeeA" /locus_tag="BSU_06760" /old_locus_tag="BSU06760" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative restriction type II methylase; HGT island" /protein_id="NP_388558.1" /db_xref="EnsemblGenomes-Gn:BSU06760" /db_xref="EnsemblGenomes-Tr:CAB12496" /db_xref="GOA:O31504" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG12818" /db_xref="UniProtKB/Swiss-Prot:O31504" /translation="MALIDLEDKIAEIVNREDHSDFLYELLGVYDVPRATITRLKKGN QNLTKRVGEVHLKNKVWFKEAKKGKLFDALIDIEQQVEYLSAKPRYLLVTDYDGVLAK DTKTLEALDVKFEELPQYFDFFLAWKGIEKVEFEKENPADIKAAERFARIYDVLRKEN NIIETNRGLDLFLIRLLFCFFAEDTDIFKRNSFTNLIKTLTEEDGSNLNKLFADLFIV LDKNERDDVPSYLKEFPYVNGQLFTEPHTELEFSAKSRKLIIECGELLNWAKINPDIF GSMIQAVASEESRSYLGMHYTSVPNIMKVIKPLFLDKLNQSFLDAYDDYTKLENLLTR IGKIKFFDPACGSGNFLIITYKELRRMEINIIKRLQELLGEYLYVPSVTLSQFYGIEI EDFAHDVAKLSLWIAEHQMNEELKNEVHNAVRPTLPLHTAGDIRCANAIRVEWTEVCP AQGSEEVYVFGNPPYLGSKKQNKEHKSDMLSIFGKVKNGKMLDYISAWFYFGAKYAST TNAKVAFVSTNSVTQGEQVSILWNELFKFGIQINFAYKSFKWANNAKNNAAVIVVIVG FGPLDTKVNKYLFVDETKKLVSNISPYLTDGENILVSSRTKPISDLPKLHFGNMPNDG GGLLFTITEYTDAINKYPELVPYFKKFIGSVEFINGGLRYCLWLNEAKYEKIKSNPLI QERISISKNHREKSTDKGTNKLALTPWKFRDTHETTNYSIVVPSVSSENRFYIPMGLA GADTILSNLIYVIYDAEIYLLGILMSRMHMTWVKAVAGRLKTDYRYSAGLCYNTFPIP ELSTRRKNEIEEAILEILDLREEQGGTLAELYNPSTMPIELKVAHEKLDGIVERAYRQ KQFESDEERLEVLLKLYQEMTER*" /label="yeeA CDS" gene 689865..692504 /gene="yeeA" /locus_tag="BSU_06760" /old_locus_tag="BSU06760" /label="yeeA gene" CDS 692516..694315 /gene="yeeB" /locus_tag="BSU_06770" /old_locus_tag="BSU06770" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative DNA helicase / endonuclease; HGT island" /protein_id="NP_388559.2" /db_xref="EnsemblGenomes-Gn:BSU06770" /db_xref="EnsemblGenomes-Tr:CAB12497" /db_xref="GOA:O34469" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12819" /db_xref="UniProtKB/Swiss-Prot:O34469" /translation="MENIIEINYNQTGKSKKTNEYGMREMQARAFEKRNSQYLLVKAP PASGKSRALMFIGLDKLINQGLRKVIVAVPERSIGSSFKNTDLKSYGFFENWKVDPRN NLTVGGDNSKVKSFVRFMESDDQVLICTHSTLRFAFEKIDDKAFDNCLLAIDEFHHVS ADVNSRLGELLRSIIHNSSAHIVAMTGSYFRGDSVPILLPEDEELFDKVTYSYYEQLD GYEYLKGFGIGYHFYQGQYTSAINEVLDTNKKTIVHIPNVNSGESTKDKYDEVGKILD MIGEVEYQDDDTGIIYVKRHSDGKTLKIADLVDDQVGRENVVAYLRNIEALDDLDIII ALGMAKEGFDWPFCEHTLTVGYRGSLTEIVQIIGRCTRDSYNKTYAQFTNLIAMPDAK DEVVTYTVNTMLKAISASLLMEQVLTPDFKFKRRRNESEKSSTTGELFVKGLKEPSTE NVKKIIENDINDLKAKIMQDSQVQKTFSGEVDPKVLNKVLIPKVIQKVYPNLSDEEIE EVRQHVVLDTVMKGAKSEVVGSKEFIRMADKFINIEDLDINLIDSINPFQKAFEVLSK ELNSPVLKLIQETIDAKRINFDEDELVFIWPKV*" /label="yeeB CDS" gene 692516..694315 /gene="yeeB" /locus_tag="BSU_06770" /old_locus_tag="BSU06770" /label="yeeB gene" promotor_-10 complement(692756..692771) /Source="Nicolas_upshift_promotors" /id="U519" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1689 /SigmaFactorBS="cagttaaattatttctaggatcaactttccaattttcaaAGA AACCATAactttttaaatCCGTATTTTTAAATGAagaacctatagagcgttcaggtac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(692771) /Source="Nicolas_upshifts" /id="U519" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1689 /SigmaFactorBS="cagttaaattatttctaggatcaactttccaattttcaaAGA AACCATAactttttaaatCCGTATTTTTAAATGAagaacctatagagcgttcaggtac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(692783..692792) /Source="Nicolas_upshift_promotors" /id="U519" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1689 /SigmaFactorBS="cagttaaattatttctaggatcaactttccaattttcaaAGA AACCATAactttttaaatCCGTATTTTTAAATGAagaacctatagagcgttcaggtac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 694316..694427 /Source="Nicolas_S_feature" /locus_tag="new_744739_744850" /HighExp="Cold, G180, G135, G150, H2O2, Paraq, HPh, LPh, Oxctl, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S243" CDS 694428..695576 /gene="yeeC" /locus_tag="BSU_06780" /old_locus_tag="BSU06780" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; HGT island" /protein_id="NP_388560.2" /db_xref="EnsemblGenomes-Gn:BSU06780" /db_xref="EnsemblGenomes-Tr:CAB12498" /db_xref="InterPro:IPR018306" /db_xref="SubtiList:BG12820" /db_xref="UniProtKB/Swiss-Prot:O34352" /translation="MASNRYHSINEIMESQLFYQITTPPKKTQKAQYDPEVEKFLEII EFVKENGREPQKVPTDLTERSLASRLIGIRKDPDRMEYLKEYDEIGLLEVRSKELTIP KISSIDDILKSGLSALLGDNLNNDITRSIFDTSSLQKVTTMPEYVAKRKKIKDFGKFE ELFKKCHKEITEGKRKILTFKNEQDIQSNSFYILKGVLLYVEDVGERKKAKGKTNARL RCIFENGTESDMLLRSLSAELYKHGRRVTDNEDTLLDNVREDDVSTGFIYVLKSLSTD PQISSIKNLYKIGFTTGSVENRIRNAENQSTYLYAPVEIVTTYQVFNMNASKFETAIH HALANNNLDVSILGANGKMLVPKEWFVVTLEDLQAVIDEIVMMVHLYD*" /label="yeeC CDS" gene 694428..695576 /gene="yeeC" /locus_tag="BSU_06780" /old_locus_tag="BSU06780" /label="yeeC gene" S_feature 695577..696766 /Source="Nicolas_S_feature" /locus_tag="new_746000_747189" /HighExp="Cold, G135, H2O2, G180, G150, LPh, C30, HPh, BMM, Paraq" /AntisenseName="yeeD" /AntisenseCor="-0.41772847620445203" /AntisenseRegPval="-12.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S244" CDS complement(695838..696143) /gene="yeeD" /locus_tag="BSU_06790" /old_locus_tag="BSU06790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; HGT island" /protein_id="NP_388561.1" /db_xref="EnsemblGenomes-Gn:BSU06790" /db_xref="EnsemblGenomes-Tr:CAB12499" /db_xref="SubtiList:BG12821" /db_xref="UniProtKB/Swiss-Prot:O34950" /translation="MTVRKELIKQINLTITVIKTINQKNPTPMVKNILKRYEEAKEFI LQSSDGKFEEDLSKVRNKLDTLTRAYLESANDYMNPMLKEMHKTEKLLKEYDETTQS* " /label="yeeD CDS" gene complement(695838..696143) /gene="yeeD" /locus_tag="BSU_06790" /old_locus_tag="BSU06790" /label="yeeD gene" CDS complement(696210..696416) /gene="yezA" /locus_tag="BSU_06800" /old_locus_tag="BSU06800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="hypothetical protein; HGT island" /protein_id="NP_388562.1" /db_xref="EnsemblGenomes-Gn:BSU06800" /db_xref="EnsemblGenomes-Tr:CAB12500" /db_xref="GOA:O31505" /db_xref="InterPro:IPR000290" /db_xref="InterPro:IPR035900" /db_xref="SubtiList:BG12872" /db_xref="UniProtKB/Swiss-Prot:O31505" /translation="MDKLTKEELIFLVKELMNPTLDDEKVSEYLDLLEKNVPYPAPSD LIFWSNEDYTAEQVVKIALNYKDE*" /label="yezA CDS" gene complement(696210..696416) /gene="yezA" /locus_tag="BSU_06800" /old_locus_tag="BSU06800" /label="yezA gene" CDS complement(696656..697111) /gene="yezG" /locus_tag="BSU_06811" /old_locus_tag="BSU06811" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; HGT island" /protein_id="YP_003097692.1" /db_xref="EnsemblGenomes-Gn:BSU06811" /db_xref="EnsemblGenomes-Tr:CAX52579" /db_xref="InterPro:IPR006728" /db_xref="InterPro:IPR036170" /db_xref="UniProtKB/Swiss-Prot:C0H3X4" /translation="MQDLYQLIGEKLNDIIPGEWTKIYLYAEVLDDSTMVLFHFRTPE NNQIIYSQDIPSHYNVSKDIFKTLLRELRELFEELRTEHRNNNDDVWTNLTLTLDRSG EFQLDYNYDDILASELDGYERIAIWEYKNLGILPEDEDDKEFVISYLGL*" /label="yezG CDS" gene complement(696656..697111) /gene="yezG" /locus_tag="BSU_06811" /old_locus_tag="BSU06811" /label="yezG gene" downshifts complement(696669) /Source="Nicolas_upshifts" /id="D335" /incds=0 /nref=41 /ntot=213 /MaxReadThrough="4.42275" /MaxDrop="5.23695" /score="10.2582155" /energy="-11.7" /TU="U520,U521" /idTUdmin="U520" /TUdmin="-529" /isTUend="FALSE" /label="downshifts" CDS complement(697131..699140) /gene="yeeF" /locus_tag="BSU_06812" /old_locus_tag="BSU06812" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative nucleic acid binding protein; HGT island" /protein_id="NP_388563.2" /db_xref="EnsemblGenomes-Gn:BSU06812" /db_xref="EnsemblGenomes-Tr:CAB12501" /db_xref="GOA:O31506" /db_xref="InterPro:IPR006829" /db_xref="SubtiList:BG12822" /db_xref="UniProtKB/Swiss-Prot:O31506" /translation="MKVFEAKTLLSEATDRAKEYKELRTQMVNLRKALKGVADLSDSE FSGKGASNIKAFYHDHVGVADQWIDYIDMKIAFFNSIAGAAEDKGLSDAYIEESFLEH ELANANKKSKSIMSEQKKAMKDILNDIDDILPLDLFSTETFKDELADANDKRKKTLEK LDALDEDLKTEYALSEPNEQFIKSDFQKLQEATGKGKNATPIHYNAKAYRESDIHKKK GDIEKRTEAYLKIKKEEAKEREIEKLKERLKNYDYADADEFYEMAKTIGYENLTAEQQ RYFTQIENTRELEAGFKGVAVGLYDSGKDAVVGLWDMVTDPGGTVEAITGAMAHPIKT YEAISAAIEESYQKDMVNGDTYSRARWVSYAVGTVVTSIVGTKGVGAVSKTGTAAKVT TKVKTAASKSATAQKAITVSKQTVDHIKQKVNTGIEVSKKHVKTKLNQIGDLTLADIL PYHPRHDLVPAGVPYNAVNGVTLKEGLQKFAKVILPKPYGTSSSGRRTPAPHVPPVTV KYGEHFARWSRKKVLKPNIIYKTKEGYTYTTDNYGRITSVKADLQLGEAKRNQYAQTN AGKPQDRKPDDDGGHLIATQFKGSGQFDNIVPMNSQINRSGGKWYEMEQEWAKALSKK PPKKVAVQIEPVYSGDSLRPSYFDVTYKIGSRKEISVSIKNQPGG*" /label="yeeF CDS" gene complement(697131..699140) /gene="yeeF" /locus_tag="BSU_06812" /old_locus_tag="BSU06812" /label="yeeF gene" promotor_-10 complement(697498..697517) /Source="Nicolas_upshift_promotors" /id="U520" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig="0.999000999001" /xcortree=2752 /SigmaFactorBS="aatatcatctacaaaacaaaagaaggctacACGTACacgact gacaacTATGGTAGAATTACAAGTGTcaaagcagacttgcagctgggagaagcgaaac g" /listShort="yezG, yezA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(697505) /Source="Nicolas_upshifts" /id="U520" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig="0.999000999001" /xcortree=2752 /SigmaFactorBS="aatatcatctacaaaacaaaagaaggctacACGTACacgact gacaacTATGGTAGAATTACAAGTGTcaaagcagacttgcagctgggagaagcgaaac g" /listShort="yezG, yezA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(697530..697535) /Source="Nicolas_upshift_promotors" /id="U520" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig="0.999000999001" /xcortree=2752 /SigmaFactorBS="aatatcatctacaaaacaaaagaaggctacACGTACacgact gacaacTATGGTAGAATTACAAGTGTcaaagcagacttgcagctgggagaagcgaaac g" /listShort="yezG, yezA" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(699167..699186) /Source="Nicolas_upshift_promotors" /id="U521" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig="0.994005994005994" /xcortree=2985 /SigmaFactorBS="atgactcatttttccaccaaaacacgttctcacccccacctt atcccgaccCGTGGTAAAATTTTGATATTgagcgaacaaaagaagggaaatggtcatg a" /listShort="yeeF, yezG, yezA, yeeD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(699177) /Source="Nicolas_upshifts" /id="U521" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig="0.994005994005994" /xcortree=2985 /SigmaFactorBS="atgactcatttttccaccaaaacacgttctcacccccacctt atcccgaccCGTGGTAAAATTTTGATATTgagcgaacaaaagaagggaaatggtcatg a" /listShort="yeeF, yezG, yezA, yeeD" /GFF_Attribute="listLong" /label="upshifts" CDS 699352..700374 /gene="yeeG" /locus_tag="BSU_06820" /old_locus_tag="BSU06820" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative phage receptor protein" /protein_id="NP_388564.2" /db_xref="EnsemblGenomes-Gn:BSU06820" /db_xref="EnsemblGenomes-Tr:CAB12502" /db_xref="GOA:O31507" /db_xref="InterPro:IPR015943" /db_xref="SubtiList:BG12823" /db_xref="UniProtKB/Swiss-Prot:O31507" /translation="MTKKRITFGLLVLMVCVILFVLYVQLRNKDSIPVQSSAIHPEED RIFFIYSNPFIKESVLLSTSTGERFNRRTFKVADVPYIQTKSYASTDLVLLAEHEPFY YTLEKDVIKEHPLSDPFAFWYEGKDVTIEAYNVDTTGNEIHINDRKTKKEYTLTLPPL VTMGASDENFIYIIQSMSIYVIDRKTEEMIETLSLASYADQFADSEEFIVASSDHKLT VIEKGTWKTTYIAYPEDLEYADTVYYDKESGSFYVAYEDKEGGANLLEYGEDFSIHTY SLKFPYMEAKFKGNLLYIVAQEEHKKGIGGYVGVFDIHSKEMLYQFDLPEEQVKVQDF VVVDNK*" /label="yeeG CDS" gene 699352..700374 /gene="yeeG" /locus_tag="BSU_06820" /old_locus_tag="BSU06820" /label="yeeG gene" promotor_-35 700474..700481 /Source="Nicolas_upshift_promotors" /id="U522" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.466533466533467" /psig="0.997002997002997" /xcortree=2961 /SigmaFactorBS="caaattgacaggatgaaaaaacaatttcttccttctatATTG TTTTcaaaatttgggatTGATAGAATATGACATATCTcatagagaaggagggaagccg t" /listShort="rapH, phrH, S245, yeeI" /listLong="yeeK" /label="promotor_-35" promotor_-10 700495..700514 /Source="Nicolas_upshift_promotors" /id="U522" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.466533466533467" /psig="0.997002997002997" /xcortree=2961 /SigmaFactorBS="caaattgacaggatgaaaaaacaatttcttccttctatATTG TTTTcaaaatttgggatTGATAGAATATGACATATCTcatagagaaggagggaagccg t" /listShort="rapH, phrH, S245, yeeI" /listLong="yeeK" /label="promotor_-10" upshifts 700496 /Source="Nicolas_upshifts" /id="U522" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.466533466533467" /psig="0.997002997002997" /xcortree=2961 /SigmaFactorBS="caaattgacaggatgaaaaaacaatttcttccttctatATTG TTTTcaaaatttgggatTGATAGAATATGACATATCTcatagagaaggagggaagccg t" /listShort="rapH, phrH, S245, yeeI" /listLong="yeeK" /label="upshifts" CDS 700536..701666 /gene="rapH" /locus_tag="BSU_06830" /old_locus_tag="BSU06830" /EC_number="3.1.-.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16553878, 21908671" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16553878, 21908671; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="response regulator aspartate phosphatase" /protein_id="NP_388565.2" /db_xref="EnsemblGenomes-Gn:BSU06830" /db_xref="EnsemblGenomes-Tr:CAB12503" /db_xref="GOA:Q59HN8" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="PDB:3Q15" /db_xref="SubtiList:BG11031" /db_xref="UniProtKB/Swiss-Prot:Q59HN8" /translation="MSQAIPSSRVGVKINEWYKMIRQFSVPDAEILKAEVEQDIQQME EDQDLLIYYSLMCFRHQLMLDYLEPGKTYGNRPTVTELLETIETPQKKLTGLLKYYSL FFRGMYEFDQKEYVEAIGYYREAEKELPFVSDDIEKAEFHFKVAEAYYHMKQTHVSMY HILQALDIYQNHPLYSIRTIQSLFVIAGNYDDFKHYDKALPHLEAALELAMDIQNDRF IAISLLNIANSYDRSGDDQMAVEHFQKAAKVSREKVPDLLPKVLFGLSWTLCKAGQTQ KAFQFIEEGLDHITARSHKFYKELFLFLQAVYKETVDERKIHDLLSYFEKKNLHAYIE ACARSAAAVFESSCHFEQAAAFYRKVLKAQEDILKGECLYAY*" /label="rapH CDS" gene 700536..701666 /gene="rapH" /locus_tag="BSU_06830" /old_locus_tag="BSU06830" /label="rapH gene" CDS 701656..701829 /gene="phrH" /locus_tag="BSU_06839" /old_locus_tag="BSU06839" /experiment="publication(s) with functional evidences, PMID:16553878, 21908671" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16553878, 21908671; Product type r: regulator" /codon_start=1 /transl_table=11 /product="hexapeptide (TDRNTT) inhibitor of regulatory cascade" /protein_id="YP_003097693.1" /db_xref="EnsemblGenomes-Gn:BSU06839" /db_xref="EnsemblGenomes-Tr:CAX52580" /db_xref="GOA:Q59HN7" /db_xref="UniProtKB/Swiss-Prot:Q59HN7" /translation="MPIKKKVMMCLAVTLVFGSMSFPTLTNSGGFKESTDRNTTYIDH SPYKLSDQKKALS*" /label="phrH CDS" gene 701656..701829 /gene="phrH" /locus_tag="BSU_06839" /old_locus_tag="BSU06839" /label="phrH gene" downshifts 701784 /Source="Nicolas_upshifts" /id="D336" /incds=0 /nref=3 /ntot=66 /MaxReadThrough="5.5891" /MaxDrop="2.9063" /score="14.5772672" /energy="-7.6" /TU="U522" /idTUdmin="U522" /TUdmin="-901" /isTUend="FALSE" /label="downshifts" S_feature 701830..701934 /Source="Nicolas_S_feature" /locus_tag="new_752253_752357" /HighExp="S2, G/S, T2.30H, GM 150, T3.0H, T2.0H, S1, T-4.40H, T-2.40H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S245" promotor_-35 701901..701908 /Source="Nicolas_upshift_promotors" /id="U523" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig="0.999000999001" /xcortree=1934 /SigmaFactorBS="cattccttctatttctaacgcaagaCACTCGAAacaaccaaa ccattTGAGGTATAATGGATAAAGTgaataacagtatttagattgatatatatgaaag a" /listShort="yeeI, yeeK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 701923..701942 /Source="Nicolas_upshift_promotors" /id="U523" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig="0.999000999001" /xcortree=1934 /SigmaFactorBS="cattccttctatttctaacgcaagaCACTCGAAacaaccaaa ccattTGAGGTATAATGGATAAAGTgaataacagtatttagattgatatatatgaaag a" /listShort="yeeI, yeeK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 701936 /Source="Nicolas_upshifts" /id="U523" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig="0.999000999001" /xcortree=1934 /SigmaFactorBS="cattccttctatttctaacgcaagaCACTCGAAacaaccaaa ccattTGAGGTATAATGGATAAAGTgaataacagtatttagattgatatatatgaaag a" /listShort="yeeI, yeeK" /GFF_Attribute="listLong" /label="upshifts" CDS 701989..702708 /gene="yeeI" /locus_tag="BSU_06840" /old_locus_tag="BSU06840" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative DNA integrase or transcriptional regulator" /protein_id="NP_388566.3" /db_xref="EnsemblGenomes-Gn:BSU06840" /db_xref="EnsemblGenomes-Tr:CAB12504" /db_xref="GOA:O31509" /db_xref="InterPro:IPR002876" /db_xref="InterPro:IPR017856" /db_xref="InterPro:IPR026562" /db_xref="InterPro:IPR026564" /db_xref="InterPro:IPR029072" /db_xref="SubtiList:BG12824" /db_xref="UniProtKB/Swiss-Prot:O31509" /translation="MGRKWNNIKEKKASKDANTSRIYAKFGREIYVAAKQGEPDPESN QALKVVLERAKTYSVPKNIIERAIEKAKGGAEENYDELRYEGFGPNGSMIIVDALTNN VNRTAPEVRAAFGKNGGNMGVSGSVAYMFDATAVIGVEGKTADEALEILMEADVDVRD ILEEDDSAIVYAEPDQFHAVQEAFKNAGVEEFTVAELTMLAQSEVTLPDDAKEQFEKL IDALEDLEDVQQVYHNVDLGE*" /label="yeeI CDS" gene 701989..702708 /gene="yeeI" /locus_tag="BSU_06840" /old_locus_tag="BSU06840" /label="yeeI gene" downshifts complement(701991) /Source="Nicolas_upshifts" /id="D337" /incds=0 /nref=3 /ntot=70 /MaxReadThrough="1.42969" /MaxDrop="3.99424" /score="-5.23712559" /energy="-7.6" /TU="NA" /idTUdmin="U520" /TUdmin="-5851" /isTUend="FALSE" /label="downshifts" promotor_-35 702566..702573 /Source="Nicolas_upshift_promotors" /id="U524" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.844155844155844" /psig="0.903096903096903" /xcortree=3101 /SigmaFactorBS="gtttaaaaacgcgggtgtcgaggaatttaCAGTAGCGgagct gacaatgcTTGCGCAAAGTGAAGTAACGcttccggatgatgcaaaggaacagtttgaa a" /listShort="yeeK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 702587..702606 /Source="Nicolas_upshift_promotors" /id="U524" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.844155844155844" /psig="0.903096903096903" /xcortree=3101 /SigmaFactorBS="gtttaaaaacgcgggtgtcgaggaatttaCAGTAGCGgagct gacaatgcTTGCGCAAAGTGAAGTAACGcttccggatgatgcaaaggaacagtttgaa a" /listShort="yeeK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 702597 /Source="Nicolas_upshifts" /id="U524" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.844155844155844" /psig="0.903096903096903" /xcortree=3101 /SigmaFactorBS="gtttaaaaacgcgggtgtcgaggaatttaCAGTAGCGgagct gacaatgcTTGCGCAAAGTGAAGTAACGcttccggatgatgcaaaggaacagtttgaa a" /listShort="yeeK" /GFF_Attribute="listLong" /label="upshifts" downshifts 702690 /Source="Nicolas_upshifts" /id="D338" /incds=0 /nref=223 /ntot=271 /MaxReadThrough="4.94236" /MaxDrop="5.19148" /score="31.0415099" /energy="-11.4" /TU="U523,U524" /idTUdmin="U522" /TUdmin=5 /isTUend="TRUE" /label="downshifts" promotor_-35 702777..702786 /Source="Nicolas_upshift_promotors" /id="U525" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1279 /SigmaFactorBS="tcccggaaattgttttagctgtatgtaggcggccGCCTATAC GAtctataagatattCTCATACTCTGGACTGTAACctatgtgaaggagagagtaaata t" /listShort="yeeK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 702800..702819 /Source="Nicolas_upshift_promotors" /id="U525" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1279 /SigmaFactorBS="tcccggaaattgttttagctgtatgtaggcggccGCCTATAC GAtctataagatattCTCATACTCTGGACTGTAACctatgtgaaggagagagtaaata t" /listShort="yeeK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 702803 /Source="Nicolas_upshifts" /id="U525" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1279 /SigmaFactorBS="tcccggaaattgttttagctgtatgtaggcggccGCCTATAC GAtctataagatattCTCATACTCTGGACTGTAACctatgtgaaggagagagtaaata t" /listShort="yeeK" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(702807..702825) /Source="Nicolas_upshift_promotors" /id="U526" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.935064935064935" /psig="0.935064935064935" /xcortree=1214 /SigmaFactorBS="aatgaccaaaaccaggtccgccatacatatgtcttgtatcaG TCATAtttactctctccttcACATAGGTTACAGTCCAGAgtatgagaatatcttatag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(702827) /Source="Nicolas_upshifts" /id="U526" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.935064935064935" /psig="0.935064935064935" /xcortree=1214 /SigmaFactorBS="aatgaccaaaaccaggtccgccatacatatgtcttgtatcaG TCATAtttactctctccttcACATAGGTTACAGTCCAGAgtatgagaatatcttatag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(702841..702846) /Source="Nicolas_upshift_promotors" /id="U526" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.935064935064935" /psig="0.935064935064935" /xcortree=1214 /SigmaFactorBS="aatgaccaaaaccaggtccgccatacatatgtcttgtatcaG TCATAtttactctctccttcACATAGGTTACAGTCCAGAgtatgagaatatcttatag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 702842..703279 /gene="cotK" /locus_tag="BSU_06850" /old_locus_tag="BSU06850" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10714992, 19060142, 19933362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10714992, 19060142, 19933362; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore inner coat protein" /protein_id="NP_388567.2" /db_xref="EnsemblGenomes-Gn:BSU06850" /db_xref="EnsemblGenomes-Tr:CAB12505" /db_xref="GOA:O31510" /db_xref="SubtiList:BG12825" /db_xref="UniProtKB/Swiss-Prot:O31510" /translation="MTDTRHMYGGPGFGHYQGFGIGHPGYGMQSTGYPGYGMYGGHPG YGMQGYPDHGIHGGVGGYPGYGGYGGYPSGGYGGSPGTGSYPSMHHENDGHHHYYHHH HDGKDNLHHHHHHVGKDNHHHHHDGHYGHHHHHMGHWGKDGYK*" /label="cotK CDS" gene 702842..703279 /gene="cotK" /locus_tag="BSU_06850" /old_locus_tag="BSU06850" /label="cotK gene" downshifts complement(702849) /Source="Nicolas_upshifts" /id="D339" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="1.62645" /MaxDrop="3.26146" /score="-5.23712559" /energy="-7.6" /TU="NA" /idTUdmin="U520" /TUdmin="-6709" /isTUend="FALSE" /label="downshifts" downshifts 703279 /Source="Nicolas_upshifts" /id="D340" /incds=0 /nref=82 /ntot=208 /MaxReadThrough="2.37564" /MaxDrop="8.21113" /score="17.7046271" /energy="-9" /TU="U525" /idTUdmin="U523" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 703339..703346 /Source="Nicolas_upshift_promotors" /id="U527" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.938061938061938" /psig="0.999000999001" /xcortree=2200 /SigmaFactorBS="cttgcagatcaagagtgtttttttagctttttTCTTGACTgt tcagtctggaaaaTGGTAACATTTGTTTCAGGAggtgatcattttttggggaggaata a" /listShort="yezE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 703362..703381 /Source="Nicolas_upshift_promotors" /id="U527" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.938061938061938" /psig="0.999000999001" /xcortree=2200 /SigmaFactorBS="cttgcagatcaagagtgtttttttagctttttTCTTGACTgt tcagtctggaaaaTGGTAACATTTGTTTCAGGAggtgatcattttttggggaggaata a" /listShort="yezE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 703367 /Source="Nicolas_upshifts" /id="U527" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.938061938061938" /psig="0.999000999001" /xcortree=2200 /SigmaFactorBS="cttgcagatcaagagtgtttttttagctttttTCTTGACTgt tcagtctggaaaaTGGTAACATTTGTTTCAGGAggtgatcattttttggggaggaata a" /listShort="yezE" /GFF_Attribute="listLong" /label="upshifts" CDS 703394..703978 /gene="yezE" /locus_tag="BSU_06860" /old_locus_tag="BSU06860" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (TetR family)" /protein_id="YP_054572.1" /db_xref="EnsemblGenomes-Gn:BSU06860" /db_xref="EnsemblGenomes-Tr:CAE01448" /db_xref="GOA:Q7WY76" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG14194" /db_xref="UniProtKB/Swiss-Prot:Q7WY76" /translation="MGRNKEFDTALVLHRAIEVFGEYGYEGTSLQDLLSHLGIARQSL YDTYGTKRDLFLSAVKSYLEGKNAAVMERLEAPGSVKEAIRDIFQEGVNALRDPERAK ACYIINSAIEQIPHDPELARYFERQSKQLEDAFYHGLLRAKDQGELNGEDTDISALAR YLNQSRLSLTFIAKVTADMDRLQDHVDVSLSVLD*" /label="yezE CDS" gene 703394..703978 /gene="yezE" /locus_tag="BSU_06860" /old_locus_tag="BSU06860" /label="yezE gene" downshifts 703959 /Source="Nicolas_upshifts" /id="D341" /incds=0 /nref=26 /ntot=216 /MaxReadThrough="2.43615" /MaxDrop="3.31193" /score="17.7046271" /energy="-9" /TU="NA" /idTUdmin="U527" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS 704057..704500 /gene="yesE" /locus_tag="BSU_06870" /old_locus_tag="BSU06870" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388568.1" /db_xref="EnsemblGenomes-Gn:BSU06870" /db_xref="EnsemblGenomes-Tr:CAB12506" /db_xref="InterPro:IPR009959" /db_xref="InterPro:IPR032710" /db_xref="PDB:1S5A" /db_xref="SubtiList:BG12844" /db_xref="UniProtKB/Swiss-Prot:O31511" /translation="MLMNEFEKACETLRKFMAYMLEKDMKSWTELWDENAVFEFPYAP EGSPKRIEGKAAIYDYIKDYPKQIHLSSFTAPTVYRSADSNTVIAEFQCDGHVIETGL PYRQSYISVIETRDGRIVRYRDYWNPLVVKEAFGGSFLQTEESGK*" /label="yesE CDS" gene 704057..704500 /gene="yesE" /locus_tag="BSU_06870" /old_locus_tag="BSU06870" /label="yesE gene" CDS 704497..705357 /gene="yesF" /locus_tag="BSU_06880" /old_locus_tag="BSU06880" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 21494745; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388569.1" /db_xref="EnsemblGenomes-Gn:BSU06880" /db_xref="EnsemblGenomes-Tr:CAB12507" /db_xref="GOA:O31512" /db_xref="InterPro:IPR001509" /db_xref="InterPro:IPR008030" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11808" /db_xref="UniProtKB/Swiss-Prot:O31512" /translation="MMKQNPILITGGTGTVGSRIASRLIKLGYRVRIASRKKGALADA EYVYFNWKYASSFTPALEQVKQIYLVAPVGVFDPAPYVLPFLKEAKRLGAKRVVMQSA SVVSENGPVFGALHQAVREFPEWTVLRPSYFMQNFINVQHRMSIQTEGRITTASGEGK LGFIDADDIAETAVRALIDDVPHQTHHILTGPEALSYAEAAEIIGAAAGRRVEHVSIS RSELQHKMEAGGLPADYAHFMAKLDEAISHGAEHRVTDTVKRVTGKEPRSLSEFAAAH AAYWTSFWTE*" /label="yesF CDS" gene 704497..705357 /gene="yesF" /locus_tag="BSU_06880" /old_locus_tag="BSU06880" /label="yesF gene" promotor_-35 705419..705424 /Source="Nicolas_upshift_promotors" /id="U528" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1097 /SigmaFactorBS="ccgaaggtcttcttattgaaaaagctaagtcgtgttttaGTC ATAatcatgcctcctgccTCATACCTATTAAGGTCATtgtttttgagaaaggaggagc c" /listShort="cotJA, cotJB, cotJC, S246, yesJ, yesK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 705440..705458 /Source="Nicolas_upshift_promotors" /id="U528" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1097 /SigmaFactorBS="ccgaaggtcttcttattgaaaaagctaagtcgtgttttaGTC ATAatcatgcctcctgccTCATACCTATTAAGGTCATtgtttttgagaaaggaggagc c" /listShort="cotJA, cotJB, cotJC, S246, yesJ, yesK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 705440 /Source="Nicolas_upshifts" /id="U528" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1097 /SigmaFactorBS="ccgaaggtcttcttattgaaaaagctaagtcgtgttttaGTC ATAatcatgcctcctgccTCATACCTATTAAGGTCATtgtttttgagaaaggaggagc c" /listShort="cotJA, cotJB, cotJC, S246, yesJ, yesK" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(705462..705476) /Source="Nicolas_upshift_promotors" /id="U529" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=707 /SigmaFactorBS="ggcgtatatgatttgacaggcgtaaacggctgcatatccTTC ATtccggctCCTCCTTTCTCAAAAacaatgaccttaataggtatgaggcaggaggcat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(705467) /Source="Nicolas_upshifts" /id="U529" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=707 /SigmaFactorBS="ggcgtatatgatttgacaggcgtaaacggctgcatatccTTC ATtccggctCCTCCTTTCTCAAAAacaatgaccttaataggtatgaggcaggaggcat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(705484..705488) /Source="Nicolas_upshift_promotors" /id="U529" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=707 /SigmaFactorBS="ggcgtatatgatttgacaggcgtaaacggctgcatatccTTC ATtccggctCCTCCTTTCTCAAAAacaatgaccttaataggtatgaggcaggaggcat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 705484..705732 /gene="cotJA" /locus_tag="BSU_06890" /old_locus_tag="BSU06890" /function="16.5: Explore" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9364920" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9364920; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the inner spore coat" /protein_id="NP_388570.1" /db_xref="EnsemblGenomes-Gn:BSU06890" /db_xref="EnsemblGenomes-Tr:CAB12508" /db_xref="InterPro:IPR020256" /db_xref="SubtiList:BG11799" /db_xref="UniProtKB/Swiss-Prot:Q45536" /translation="MKDMQPFTPVKSYTPFHSRFDPCPPIGKKYYRTPPNLYMTFQPE HMEQFSPMEALRKGTLWKDLYDFYENPYRGGDAHGKKG*" /label="cotJA CDS" gene 705484..705732 /gene="cotJA" /locus_tag="BSU_06890" /old_locus_tag="BSU06890" /label="cotJA gene" CDS 705716..705979 /gene="cotJB" /locus_tag="BSU_06900" /old_locus_tag="BSU06900" /function="16.13: Shape" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9364920" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9364920; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the inner spore coat" /protein_id="NP_388571.2" /db_xref="EnsemblGenomes-Gn:BSU06900" /db_xref="EnsemblGenomes-Tr:CAB12509" /db_xref="InterPro:IPR016571" /db_xref="InterPro:IPR024207" /db_xref="SubtiList:BG11800" /db_xref="UniProtKB/Swiss-Prot:Q45537" /translation="MAKKVDAEYYRQLEQIQAADFVLVELSLYLNTHPHDEDALKQFN QYSGYSRHLKRQFESSYGPLLQFGNSPAGKDWDWGKGPWPWQV*" /label="cotJB CDS" gene 705716..705979 /gene="cotJB" /locus_tag="BSU_06900" /old_locus_tag="BSU06900" /label="cotJB gene" CDS 705994..706563 /gene="cotJC" /locus_tag="BSU_06910" /old_locus_tag="BSU06910" /EC_number="1.11.1.6" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:7768848, 9364920" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7768848, 9364920; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="enzyme component of the inner spore coat" /protein_id="NP_388572.1" /db_xref="EnsemblGenomes-Gn:BSU06910" /db_xref="EnsemblGenomes-Tr:CAB12510" /db_xref="InterPro:IPR007760" /db_xref="InterPro:IPR009078" /db_xref="InterPro:IPR012347" /db_xref="SubtiList:BG11801" /db_xref="UniProtKB/Swiss-Prot:Q45538" /translation="MWVYEKKLQYPVKVSTCNPTLAKYLIEQYGGADGELAAALRYLN QRYTIPDKVIGLLTDIGTEEFAHLEMIATMVYKLTKDATPEQLREAGLGDHYVNHDSA LFYHNAAGVPFTASYIQAKGDPIADLYEDIAAEEKARATYQWLIDISDDPDLNDSLRF LREREIVHSMRFREAVEILKEERDKKKIF*" /label="cotJC CDS" gene 705994..706563 /gene="cotJC" /locus_tag="BSU_06910" /old_locus_tag="BSU06910" /label="cotJC gene" S_feature 706564..706642 /Source="Nicolas_S_feature" /locus_tag="new_756987_757065" /HighExp="S4, S5, S3, S7, S6, B36, LoTm, BT, T5.0H, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S246" promotor_-35 706615..706620 /Source="Nicolas_upshift_promotors" /id="U530" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.518481518481518" /psig="0.999000999001" /xcortree=3085 /SigmaFactorBS="tcatacacccttttacatacagagaaaatggTCTGTTtttgc agtttggtcTGCATTATAATCAAGGTGTGtgtgcaagcttactttttgattgggaggc c" /listShort="yesJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 706635..706654 /Source="Nicolas_upshift_promotors" /id="U530" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.518481518481518" /psig="0.999000999001" /xcortree=3085 /SigmaFactorBS="tcatacacccttttacatacagagaaaatggTCTGTTtttgc agtttggtcTGCATTATAATCAAGGTGTGtgtgcaagcttactttttgattgggaggc c" /listShort="yesJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 706644 /Source="Nicolas_upshifts" /id="U530" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.518481518481518" /psig="0.999000999001" /xcortree=3085 /SigmaFactorBS="tcatacacccttttacatacagagaaaatggTCTGTTtttgc agtttggtcTGCATTATAATCAAGGTGTGtgtgcaagcttactttttgattgggaggc c" /listShort="yesJ" /GFF_Attribute="listLong" /label="upshifts" CDS 706688..707230 /gene="yesJ" /locus_tag="BSU_06920" /old_locus_tag="BSU06920" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_388573.1" /db_xref="EnsemblGenomes-Gn:BSU06920" /db_xref="EnsemblGenomes-Tr:CAB12511" /db_xref="GOA:O31513" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11809" /db_xref="UniProtKB/Swiss-Prot:O31513" /translation="MTAFKIENETIADGFYACPAVYEDAESITGLLVRTAEWLRDRGS NQWSGLLKGQDIHDITGSIEKGHVFVFKKDEELAAVVMLLPAPSEWDRTLWGDDGHEE SIYLHRLAVSRRFAGQGLGARVLQWAETGIHFPEKTRIRLDCVADSDALHSFYRRMGY EFMGADASGYHLFEKEITAE*" /label="yesJ CDS" gene 706688..707230 /gene="yesJ" /locus_tag="BSU_06920" /old_locus_tag="BSU06920" /label="yesJ gene" downshifts 707197 /Source="Nicolas_upshifts" /id="D342" /incds=0 /nref=104 /ntot=251 /MaxReadThrough="3.04389" /MaxDrop="4.5316" /score="8.56782582" /energy="-5.8" /TU="U528" /idTUdmin="U530" /TUdmin=2 /isTUend="TRUE" /label="downshifts" CDS 707253..707555 /gene="yesK" /locus_tag="BSU_06930" /old_locus_tag="BSU06930" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane component" /protein_id="NP_388574.2" /db_xref="EnsemblGenomes-Gn:BSU06930" /db_xref="EnsemblGenomes-Tr:CAB12512" /db_xref="GOA:O31514" /db_xref="InterPro:IPR025434" /db_xref="SubtiList:BG12845" /db_xref="UniProtKB/Swiss-Prot:O31514" /translation="MSFSKREAGDVWSILFVTGIVTACLFAGVSVLMRMRFPDKSRPE WMLAGLIVLGVFAIWYSLVYVRGWEGAALGMLGFNVIFGAIAGYLIDKAIRRYRKR*" /label="yesK CDS" gene 707253..707555 /gene="yesK" /locus_tag="BSU_06930" /old_locus_tag="BSU06930" /label="yesK gene" promotor_-35 707598..707606 /Source="Nicolas_upshift_promotors" /id="U531" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.895104895104895" /psig="0.895104895104895" /xcortree=362 /SigmaFactorBS="gccgtctctcaacaggtcgaaattttcacagaccgGCAGGAA TTttctttcgaaAGGAGAAATACATATTACTttaaaatgaaagcgttttccaaagcag g" /listShort="yesL, yesM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 707617..707635 /Source="Nicolas_upshift_promotors" /id="U531" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.895104895104895" /psig="0.895104895104895" /xcortree=362 /SigmaFactorBS="gccgtctctcaacaggtcgaaattttcacagaccgGCAGGAA TTttctttcgaaAGGAGAAATACATATTACTttaaaatgaaagcgttttccaaagcag g" /listShort="yesL, yesM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 707623 /Source="Nicolas_upshifts" /id="U531" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.895104895104895" /psig="0.895104895104895" /xcortree=362 /SigmaFactorBS="gccgtctctcaacaggtcgaaattttcacagaccgGCAGGAA TTttctttcgaaAGGAGAAATACATATTACTttaaaatgaaagcgttttccaaagcag g" /listShort="yesL, yesM" /GFF_Attribute="listLong" /label="upshifts" CDS 707670..708299 /gene="yesL" /locus_tag="BSU_06940" /old_locus_tag="BSU06940" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 25441682; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease or sensor of a three componentsystem for pectin and rhamnogalacturonan transport anddegradation" /protein_id="NP_388575.1" /db_xref="EnsemblGenomes-Gn:BSU06940" /db_xref="EnsemblGenomes-Tr:CAB12513" /db_xref="GOA:O31515" /db_xref="InterPro:IPR006938" /db_xref="SubtiList:BG12846" /db_xref="UniProtKB/Swiss-Prot:O31515" /translation="MLMIHSVANGLNHFCTWVMRLAYLNVLWILFSLAGLVVFGLMPA TAAMFTVAREWAKGNTDAPVFSVFFRTFKKEWRASQILGLIVVTAALFLFADMRIAAQ MDQPVLVNVFVSISLIFAFVVLYVFPVFSHFDVKIREVLSISFFIAFSRPAVTLLMAA GAVGVLCLVLFHVTFLLFFSGSLLSLILTKLSFKAFRSMDQRQEKEKAA*" /label="yesL CDS" gene 707670..708299 /gene="yesL" /locus_tag="BSU_06940" /old_locus_tag="BSU06940" /label="yesL gene" CDS 708296..710029 /gene="yesM" /locus_tag="BSU_06950" /old_locus_tag="BSU06950" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 23436677, 25441682" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 23436677, 25441682; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YesN]" /protein_id="NP_388576.1" /db_xref="EnsemblGenomes-Gn:BSU06950" /db_xref="EnsemblGenomes-Tr:CAB12514" /db_xref="GOA:O31516" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR010559" /db_xref="InterPro:IPR033479" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12847" /db_xref="UniProtKB/Swiss-Prot:O31516" /translation="MKKRVAGWYRRMKIKDKLFVFLSLIMAVSFLFVYSGVQYAFHVY DEQIYRKSSEVLRMSSERIEDELKKIEDVSYEIITDEQIQRILSMQNRDDTYDQYQMK QELWDQLAGYASDEKYIDSIHVIDARGSEYSAGSSSSDLLQQEQEEVFKRAKAKSGRN LWMTLGGSDPVLISARQIRSYHQLSLNGLGMVLIQVNVKQMIRDVPKDWGDSVGDIMI ADQGGNLVYTAHASAHVPEAAKETLKHPGYDLIKKNGKRYFISYLQSSYQNWSYYNVI PFDQMFAKISFMKTVIGTCFLLFFCVVLLFGRKIANSITEPIEQLVTAMKSVQHSGIE AGVSLSLPEHTQDEAGMLNRHFTVMMKRINELMEENVEKQLIIKETELKALQAQINPH FLYNTLESINWLAKANQQKQISKMVESLGFLLRNSIHMKKDIVTIQEEADIVRHYMTI QRFRFEERLKFTLDIDDEVKHCLIPKLTLQPLAENAIQYALEPFTRPCAIRIQAKKAK GCVCITVEDNGPGMDGRILESTGGRGIGLWNIRERISLTFGEPYGLRIHSEHEKGTRI VITIPCRNEVV*" /label="yesM CDS" gene 708296..710029 /gene="yesM" /locus_tag="BSU_06950" /old_locus_tag="BSU06950" /label="yesM gene" CDS 710029..711135 /gene="yesN" /locus_tag="BSU_06960" /old_locus_tag="BSU06960" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:25441682" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25441682; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YesM]" /protein_id="NP_388577.1" /db_xref="EnsemblGenomes-Gn:BSU06960" /db_xref="EnsemblGenomes-Tr:CAB12515" /db_xref="GOA:O31517" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR018060" /db_xref="SubtiList:BG12848" /db_xref="UniProtKB/Swiss-Prot:O31517" /translation="MYKILLADDERIILDGMAGIIEWESLGASLIGKAQNGHEAYEKI VHKQPHIVITDVKMPGMDGLELIKKVSAVSPSVQFIVLSGFGEFEYAKEAMKYGVKHY LLKPCNEQQIISSLEEIIAELKRQDVHKKKTAHLKHELDHIRSFAADQYLEGLIAGVA QLSPPPSLAGKKIRLLILKGEQSIDAAAREALGSALTAVCSSGEWTVLAVEENAAEKV AEVFADRKMAISQAGELRHAGQLFRDTAEASGDLHGSAVISKMIRLIADELGNPNLSL KWAAKDMLFMNPDYLGKLFKQETGEKFSQYVTRVRLEHAMKQMKIRRDVSVSEIAEEI GFGDNPKYFSLVFKKYTGLTPSEFRRKQGGASAG*" /label="yesN CDS" gene 710029..711135 /gene="yesN" /locus_tag="BSU_06960" /old_locus_tag="BSU06960" /label="yesN gene" downshifts 711089 /Source="Nicolas_upshifts" /id="D343" /incds=0 /nref=4 /ntot=43 /MaxReadThrough="0.271749999999999" /MaxDrop="3.41261" /score="3.12085441" /energy="-10.3" /TU="NA" /idTUdmin="U531" /TUdmin=1408 /isTUend="FALSE" /label="downshifts" promotor_-35 711174..711177 /Source="Nicolas_upshift_promotors" /id="U532" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.882117882117882" /psig="0.992007992007992" /xcortree=356 /SigmaFactorBS="tctctgtttttttgactttcgccactgttttttgaGTGTttc gccctatccgaACGCTTTAAAATAAAATGTAagcacttacattaaaggggggattggt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 711192..711211 /Source="Nicolas_upshift_promotors" /id="U532" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.882117882117882" /psig="0.992007992007992" /xcortree=356 /SigmaFactorBS="tctctgtttttttgactttcgccactgttttttgaGTGTttc gccctatccgaACGCTTTAAAATAAAATGTAagcacttacattaaaggggggattggt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 711199 /Source="Nicolas_upshifts" /id="U532" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.882117882117882" /psig="0.992007992007992" /xcortree=356 /SigmaFactorBS="tctctgtttttttgactttcgccactgttttttgaGTGTttc gccctatccgaACGCTTTAAAATAAAATGTAagcacttacattaaaggggggattggt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 711239..712522 /gene="yesO" /locus_tag="BSU_06970" /old_locus_tag="BSU06970" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16781735, 17449691, 25658435" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16781735, 17449691, 25658435; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="pectin degradation byproducts (rhamnose oligosaccharides)-binding lipoprotein" /protein_id="NP_388578.2" /db_xref="EnsemblGenomes-Gn:BSU06970" /db_xref="EnsemblGenomes-Tr:CAB12516" /db_xref="PDB:4R6K" /db_xref="SubtiList:BG12849" /db_xref="UniProtKB/Swiss-Prot:O31518" /translation="MKKICYVLLSLVCVFLFSGCSAGEEASGKKEDVTLRIAWWGGQP RHDYTTKVIELYEKKNPHVHIEAEFANWDDYWKKLAPMSAAGQLPDVIQMDTAYLAQY GKKNQLEDLTPYTKDGTIDVSSIDENMLSGGKIDNKLYGFTLGVNVLSVIANEDLLKK AGVSINQENWTWEDYEKLAYDLQEKAGVYGSNGMHPPDIFFPYYLRTKGERFYKEDGT GLAYQDDQLFVDYFERQLRLVKAKTSPTPDESAQIKGMEDDFIVKGKSAITWNYSNQY LGFARLTDSPLSLYLPPEQMQEKALTLKPSMLFSIPKSSEHKKEAAKFINFFVNNEEA NQLIKGERGVPVSDKVADAIKPKLNEEETNIVEYVETASKNISKADPPEPVGSAEVIK LLKDTSDQILYQKVSPEKAAKTFRKKANEILERNN*" /label="yesO CDS" gene 711239..712522 /gene="yesO" /locus_tag="BSU_06970" /old_locus_tag="BSU06970" /label="yesO gene" CDS 712519..713448 /gene="rhgP" /locus_tag="BSU_06980" /old_locus_tag="BSU06980" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 17449691" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 17449691; Product type t: transporter" /codon_start=1 /transl_table=11 /product="rhamnogalacturonan permease" /protein_id="NP_388579.1" /db_xref="EnsemblGenomes-Gn:BSU06980" /db_xref="EnsemblGenomes-Tr:CAB12517" /db_xref="GOA:O31519" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12850" /db_xref="UniProtKB/Swiss-Prot:O31519" /translation="MTGNGADAMKKSRSIRKDNLAGYAFISPFIIGFLCFTVIPMGAS LFLSFTSYDLFTAPKWIGLDNFKEMFTGDEKYWQSLKVTFTYVLAGVPLRLGFALFIA VILNNAAKGTAIYRTLFYLPSIIGGSVAVAIMWRNIFGNDGVINALLFFVGIDQKILW YQNPTSALWTLILLSVWQFGSSMLIFLAGLKNIPSSYLEAASVDGANRVQRFFKITLP ILTPIIFFNLVMQTISAFMTFTPAYIISKGEGGPLDGTLLYSLYLFQRAFNYFQMGYA SAMAWVMLVIVGLITLILFKTSSYWVHYESKEE*" /label="rhgP CDS" gene 712519..713448 /gene="rhgP" /locus_tag="BSU_06980" /old_locus_tag="BSU06980" /label="rhgP gene" CDS 713452..714342 /gene="rhgQ" /locus_tag="BSU_06990" /old_locus_tag="BSU06990" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 17449691" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 17449691; Product type t: transporter" /codon_start=1 /transl_table=11 /product="rhamnogalacturonan permease" /protein_id="NP_388580.1" /db_xref="EnsemblGenomes-Gn:BSU06990" /db_xref="EnsemblGenomes-Tr:CAB12518" /db_xref="GOA:O31520" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12851" /db_xref="UniProtKB/Swiss-Prot:O31520" /translation="MEPVNQPVREAPVFERKKAGRVSPKRILFHVFTATLAVLLLYPV IWLFVSSFKESASIFTTSHSLIPDPFILSNYAEGWKGIAGQPFLTFIKNSAIIVGLST IGAVMSSAVIAYGFARIPFKGKKFWFACMMGTLMLPHEVLMIPQYIMFAKLDWLNSFK PIVVPQFFGHAFFIFLMIQFIRTIPEELDEAARIDGCGRFACFWRIILPLIAPALATS AIFSFYWKWEELIQPLLYLNKPELYPVSLALKLFLDTESASNWGAMFAMSAVSLLPVI LVFFLFQKYIVQGISTTGLK*" /label="rhgQ CDS" gene 713452..714342 /gene="rhgQ" /locus_tag="BSU_06990" /old_locus_tag="BSU06990" /label="rhgQ gene" CDS 714358..715392 /gene="rhgH" /locus_tag="BSU_07000" /old_locus_tag="BSU07000" /EC_number="3.2.1.172" /function="16.6: Maintain" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 16781735, 17449691; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="rhamnogalacturonan hydrolase" /protein_id="NP_388581.1" /db_xref="EnsemblGenomes-Gn:BSU07000" /db_xref="EnsemblGenomes-Tr:CAB12519" /db_xref="GOA:O31521" /db_xref="InterPro:IPR008928" /db_xref="InterPro:IPR010905" /db_xref="SubtiList:BG12852" /db_xref="UniProtKB/Swiss-Prot:O31521" /translation="MAQLIFDEEKVTSVIDRIVKRTFQMDFAWDWPGGVAFYGVAEAY EATENEEYINLLKTWVDEQLEDGLPPLSINGVSIGHTLLFLHKVTGDDVYLETAAEMA EYVLHKAPRFGEGILQHTVNAAEYVFPEQAWADTLMMAGLFMLRIGRVMEREDYFEDG LRQFHGHEDVLQDPVTNLYYHAWDNKAQNHLSGIYWGRANGWAALTMAKALPLIEVTH PSFMIIDGSLRDQLSALVRLQDESGLWHTILDDPDSYLEVSASAGIASALMSSGKLYT KYVQKSLAAILDAVEEDGRVSRVSAGTAVMKNAEGYKQVPYKRIQGWGQGLALTFLAD VLKTKKRLYQ*" /label="rhgH CDS" gene 714358..715392 /gene="rhgH" /locus_tag="BSU_07000" /old_locus_tag="BSU07000" /label="rhgH gene" CDS 715415..717700 /gene="rhgR" /locus_tag="BSU_07010" /old_locus_tag="BSU07010" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16781735, 17449691, 19651770" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16781735, 17449691, 19651770; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (AraC/XylS family)" /protein_id="NP_388582.1" /db_xref="EnsemblGenomes-Gn:BSU07010" /db_xref="EnsemblGenomes-Tr:CAB12520" /db_xref="GOA:O31522" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR018060" /db_xref="InterPro:IPR018062" /db_xref="SubtiList:BG12853" /db_xref="UniProtKB/Swiss-Prot:O31522" /translation="MKKQPQQKERVSRWKGTYFKRNFVFILLIACIPGLLTGGAIYFL SIDKVEKELQRSHETQVAREVSRMDEKLGVLELALTQMAYDSSLMNGLAERDLEKDFT FSYQLTKKLFLLRDQQPLIEQASIFLNSPRPLVLSPEYSALTEQEALRKYRSLLASDH SIYWKRSGNQAMLIQLIPGAAEKPFGAIMLAVDPKEMESILQSLSPYPDGSALLLDQN REVLFHEGEKDFEKTLLHEIKKQPAENGHFQMEWKGKVYSVSFGEMNRMHQQWTFVSA APLSAITAPMVFLSKVIIVMLVICIGLAVCMTWYASKKIYRPIQHLLGLFTGGEKKTW QASGQDEFKWIEKRWQDLSLESRKLQQQLLRQTPHMKKSFLQHLLQSDFYYDNEESLR FRMEEAGWNIGGNVFHVLDLQVTGLRCEKSIFREGDEQLAVFTLTNIAEELAAKRVFQ LSILDIGRLSVTVLVMKTNSSDLKAYITELARQFGDVTGLCLTSTLSSKTERVTEIPS LFQDVKCGKSRRKFANRDQVIDLQADFPRDEQFAPYYPFELEKQIVQTIRLERKQEAK ELIDGCMKELSEKAAIDRHVHSALIQLFSRIQEDILHSGLNPSELFQHRNPFLDISEL REPNEAAAWLMDVVVTPYLSKLEGRKNRQQKQLAERVIAMIHEQYMADISLESCADAL GMNSYTLSKAFKQVTGINFIDYVTQIRIEKAKELLVNTNKKIHDVSEEVGYRHNYFNR IFKKQVGMPPGVFRQMYQETP*" /label="rhgR CDS" gene 715415..717700 /gene="rhgR" /locus_tag="BSU_07010" /old_locus_tag="BSU07010" /label="rhgR gene" CDS 717714..718412 /gene="rhgT" /locus_tag="BSU_07020" /old_locus_tag="BSU07020" /EC_number="3.1.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16781735, 17449691, 17957779" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16781735, 17449691, 17957779; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="rhamnogalacturonan acetylesterase" /protein_id="NP_388583.1" /db_xref="EnsemblGenomes-Gn:BSU07020" /db_xref="EnsemblGenomes-Tr:CAB12521" /db_xref="GOA:O31523" /db_xref="InterPro:IPR013830" /db_xref="InterPro:IPR036514" /db_xref="SubtiList:BG12854" /db_xref="UniProtKB/Swiss-Prot:O31523" /translation="MMKKPIQVFLAGDSTVSDCPPHEAPMAGWGQVFGQLFSEGVLVR NHAKGGASTNSFVEEGRLQAIAEHITQGDYLLIQFGHNDQKPRGTKPYSTFQQFLTLF ADTAREKGAHPVFVTSVQRRRFDENGRIEHTLGEYPDAMKALAKELDVPVIDLLAKTK VLYEAYGPEESKRLFVWFQPNEHPNYPDGIEDNTHFSEKGAMEVAKLVAEGIEELGLP LKDHLVSREGKEHV*" /label="rhgT CDS" gene 717714..718412 /gene="rhgT" /locus_tag="BSU_07020" /old_locus_tag="BSU07020" /label="rhgT gene" CDS 718405..719067 /gene="yesU" /locus_tag="BSU_07030" /old_locus_tag="BSU07030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16781735, 17449691; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_388584.1" /db_xref="EnsemblGenomes-Gn:BSU07030" /db_xref="EnsemblGenomes-Tr:CAB12522" /db_xref="InterPro:IPR013320" /db_xref="InterPro:IPR015305" /db_xref="PDB:1OQ1" /db_xref="SubtiList:BG12855" /db_xref="UniProtKB/Swiss-Prot:O31524" /translation="MYKEGACLYRNPLRSKSDVKDWRMEGGGQISFDDHSLHLSHVQD EAHFVFWCPETFPDGIIVTWDFSPIEQPGLCMLFFAAAGIRGEDLFDPSLRKRTGTYP EYHSGDINALHLSYFRRKYAEERAFRTCNLRKSRGFHLAAMGADPLPSPDDADSPYRM KLIKDKGYVHFSINGLPILEWMDDGSTYGPVLTKGKIGFRQMAPMKAVYRDFAVHQAV RR*" /label="yesU CDS" gene 718405..719067 /gene="yesU" /locus_tag="BSU_07030" /old_locus_tag="BSU07030" /label="yesU gene" CDS 719064..719690 /gene="yesV" /locus_tag="BSU_07040" /old_locus_tag="BSU07040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 17449691; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane component" /protein_id="NP_388585.1" /db_xref="EnsemblGenomes-Gn:BSU07040" /db_xref="EnsemblGenomes-Tr:CAB12523" /db_xref="InterPro:IPR006938" /db_xref="SubtiList:BG12856" /db_xref="UniProtKB/Swiss-Prot:O31525" /translation="MKTTVTDALYAGCEAVVKIAWLNGLWLLFTLLGGVLFGWAPSTA AMCAVIRKWLMGQKDVPIFSLFLDTYKKEFLKVNAIGLAFSALLLILSANYHYFSAST NWLSFAVTSCTLLAGLLYIIALMYVFPLYVHYQLPLRKYIPQALLFGAMRPLTTGCML IGCGFVLYLLYTLPGLIPFYGPCLFGLVLMFFALRGFQKTEAQHHQAG*" /label="yesV CDS" gene 719064..719690 /gene="yesV" /locus_tag="BSU_07040" /old_locus_tag="BSU07040" /label="yesV gene" CDS 719811..721673 /gene="rhgW" /locus_tag="BSU_07050" /old_locus_tag="BSU07050" /EC_number="4.2.2.23" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16781735, 17449691, 19193638" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16781735, 17449691, 19193638; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="rhamnogalacturonan endolyase" /protein_id="NP_388586.1" /db_xref="EnsemblGenomes-Gn:BSU07050" /db_xref="EnsemblGenomes-Tr:CAB12524" /db_xref="GOA:O31526" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR034641" /db_xref="PDB:2Z8R" /db_xref="PDB:2Z8S" /db_xref="PDB:2ZUX" /db_xref="SubtiList:BG12857" /db_xref="UniProtKB/Swiss-Prot:O31526" /translation="MRRSCLMIRRRKRMFTAVTLLVLLVMGTSVCPVKAEGAARQMEA LNRGLVAVKTDGGIFVSWRFLGTENASVLFNVYRDGQKLNAAPVKTTNYVDKNGSAGS TYTVRAVVNGTEQPASEKASVWAQPYHSVPLDKPAGGTTPKGESYTYSANDASVGDVD GDGQYELILKWDPSNSKDNSQDGYTGDVLIDAYKLDGTKLWRINLGKNIRAGAHYTQF MVYDLDGDGKAEVAMKTADGTKDGTGKVIGNANADYRNEQGRVLSGPEYLTVFQGSTG KELVTANFEPARGNVSDWGDSYGNRVDRFLAGIAYLDGQRPSLIMTRGYYAKTMLVAY NFRDGKLSKLWTLDSSKSGNEAFAGQGNHNLSIADVDGDGKDEIIFGSMAVDHDGKGM YSTGLGHGDALHTGDLDPGRPGLEVFQVHEDKNAKYGLSFRDAATGKILWGVYAGKDV GRGMAADIDPRYPGQEVWANGSLYSAKGVKIGSGVPSSTNFGIWWDGDLLREQLDSNR IDKWDYQNGVSKNMLTASGAAANNGTKATPTLQADLLGDWREEVVWRTEDSSALRIYT TTIPTEHRLYTLMHDPVYRLGIAWQNIAYNQPPHTSFFLGDGMAEQPKPNMYTP*" /label="rhgW CDS" gene 719811..721673 /gene="rhgW" /locus_tag="BSU_07050" /old_locus_tag="BSU07050" /label="rhgW gene" promotor_no_box 719851..719951 /Source="Nicolas_upshift_promotors" /id="U533" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.59040959040959" /psig="0.000999000999001" /xcortree=1487 /SigmaFactorBS="tgtttaccgctgttacgttgctggtcttgttggtgatgggaa cctctgtatgtcctgtgaaagctgaaggggcagcgcggcagatggaagcgctgaaccg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 719911 /Source="Nicolas_upshifts" /id="U533" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.59040959040959" /psig="0.000999000999001" /xcortree=1487 /SigmaFactorBS="tgtttaccgctgttacgttgctggtcttgttggtgatgggaa cctctgtatgtcctgtgaaagctgaaggggcagcgcggcagatggaagcgctgaaccg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(720449) /Source="Nicolas_upshifts" /id="U534" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1380 /SigmaFactorBS="cattgccacttctgctttTCCGTCACCAtcaaggtcatacAC CATAAACTGGGTGTAGTGcgcgcccgctctgatgtttttgccgagattgatccgccat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(720450..720469) /Source="Nicolas_upshift_promotors" /id="U534" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1380 /SigmaFactorBS="cattgccacttctgctttTCCGTCACCAtcaaggtcatacAC CATAAACTGGGTGTAGTGcgcgcccgctctgatgtttttgccgagattgatccgccat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(720482..720491) /Source="Nicolas_upshift_promotors" /id="U534" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1380 /SigmaFactorBS="cattgccacttctgctttTCCGTCACCAtcaaggtcatacAC CATAAACTGGGTGTAGTGcgcgcccgctctgatgtttttgccgagattgatccgccat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 721719..723557 /gene="rhgX" /locus_tag="BSU_07060" /old_locus_tag="BSU07060" /EC_number="4.2.2.24" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16781735, 17449691, 19193638" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16781735, 17449691, 19193638; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="rhamnogalacturonan exolyase" /protein_id="NP_388587.1" /db_xref="EnsemblGenomes-Gn:BSU07060" /db_xref="EnsemblGenomes-Tr:CAB12525" /db_xref="GOA:O31527" /db_xref="InterPro:IPR013517" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR034641" /db_xref="PDB:2ZUY" /db_xref="SubtiList:BG12858" /db_xref="UniProtKB/Swiss-Prot:O31527" /translation="MKPKKRQMEYLTRGLIAVQTEQGVFVSWRFLGTDHETTAFHLYR DGKRITRDPIAESTNFLDQNGTADSVYQVAAVNKGREEKLSKKARVWQENVLEVPLAK PEGGVTPDGKPYTYSANDASVGDIDGDGEYEMILKWDPSNSKDNAHDGYTGEVLIDAY KLDGTFLWRINLGRNIRAGAHYTQFMVYDLDGDGKAEIAMKTADGTTDGKGHIIGDEQ ADFRNEQGRILSGPEYLTVFKGETGEALTTVEYEPPRGKLEDWGDGYGNRMDRFLAGT AYLDGERPSLVMARGYYTRTVLVAYDFRNGRLKKRWVFDSNQPGHEAYAGQGNHSLSV ADVDGDGKDEIIYGAMAVDHDGTGLYSTGLGHGDAMHVGDLDPSRKGLEVFQVHEDAT KPYGLSLRDAGTGEILWGVHAGTDVGRGMAAHIDPSYKGSLVWGIDPPGNDGMSYGLF TSKGEKISDKAPSSANFAIWWDGDLVRELLDHDWDGTIGRPKIEKWDAENGCLKTIFQ PAGVLSNNGTKGNPVLQANLFGDWREEVIWRTEDSSALRIYTTTHLTRHCFYTLMHDP VYRLGIAWQNTAYNQPPHTSFYLGTGMKKPPKPALYIAGSKAEAPL*" /label="rhgX CDS" gene 721719..723557 /gene="rhgX" /locus_tag="BSU_07060" /old_locus_tag="BSU07060" /label="rhgX gene" CDS 723715..724368 /gene="yesY" /locus_tag="BSU_07070" /old_locus_tag="BSU07070" /EC_number="3.1.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16781735, 17449691" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16781735, 17449691; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="rhamnogalacturonan acetylesterase" /protein_id="NP_388588.1" /db_xref="EnsemblGenomes-Gn:BSU07070" /db_xref="EnsemblGenomes-Tr:CAB12526" /db_xref="GOA:O31528" /db_xref="InterPro:IPR013830" /db_xref="InterPro:IPR036514" /db_xref="SubtiList:BG12859" /db_xref="UniProtKB/Swiss-Prot:O31528" /translation="MANHIYLAGDSTVQTYGDSTNQGGWGQFLGSHLPEHIQVINRAI GGRSSKTFVEEGRLQAILDVIEPDDWLFVQMGHNDASKNKPERYTEPYTTYKQYLKQY IAGAREKGAHPLLITPVARFHYENGVFLNDFPDYCIAMKQTAAEENVQLIDLMEKSLA FFTEKGEEKVYTYFMISEGINDYTHFTKKGANEMAKLVAKGIKELGLPLTESIIKER* " /label="yesY CDS" gene 723715..724368 /gene="yesY" /locus_tag="BSU_07070" /old_locus_tag="BSU07070" /label="yesY gene" CDS 724376..726367 /gene="rhgZ" /locus_tag="BSU_07080" /old_locus_tag="BSU07080" /EC_number="3.2.1.67" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16781735, 17056685, 17449691, 17485082" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16781735, 17056685, 17449691, 17485082; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="beta-galacturonidase" /protein_id="NP_388589.1" /db_xref="EnsemblGenomes-Gn:BSU07080" /db_xref="EnsemblGenomes-Tr:CAB12527" /db_xref="GOA:O31529" /db_xref="InterPro:IPR003476" /db_xref="InterPro:IPR013529" /db_xref="InterPro:IPR013738" /db_xref="InterPro:IPR013739" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG12860" /db_xref="UniProtKB/Swiss-Prot:O31529" /translation="MRKLYHGACYYPELWDEETIQQDIDIMREVGVNVVRIGEFAWSV MEPEEGKIDVGFFKEIIARLYDSGIETIMCTPTPTPPIWFSHGRPERMHANEKREIMG HGSRQHACTNNPYFRKKAAIITTAIAKELGRLPGLIGWQLDNEFKCHVAECMCETCLR LWHDWLKNRYGVIERLNEAWGTDVWSETYQTFEQVPQPGPAPFLHHASLRTMYQLFSM EMIASFADEQAKIIRCYSDAPITHNGSVMFSVDNERMFQNLDFASYDTYASQENASAF LLNCDLWRNLKQGRPFWILETSPSYAASLESSAYPHADGYLQAEAVSSYALGSQGFCY WLWRQQRSGSEISHGSVLSAWGEPTIGYQNVLAVERARKEIEPIILSTEPVQAEAAMT YSDRAKAFIKTEPHRGLRHRSLVTHFYERILNTGIHRDLIPEGAPLDGYRLLFTPFVP YLSSEFIKKASAFAEAGGIWITGPLTGGRTCEHTIHTDCGLGELEKTSGIKTLFTFPM NENVNTGKAFGITAPLGLWSAVFDTESGNTLGTVEAGPGAGHAFLTERNYGEGKIVML GSLPSGKEGDAMLEALVRHYAEEAVISSRSDVTPGTIVAPRIGENGLVWIVVNMDGKG GSVTLPESGTDLLTHRLEKAGRLAVGPHEYRVIQFDNHS*" /label="rhgZ CDS" gene 724376..726367 /gene="rhgZ" /locus_tag="BSU_07080" /old_locus_tag="BSU07080" /label="rhgZ gene" CDS 726411..728984 /gene="yetA" /locus_tag="BSU_07090" /old_locus_tag="BSU07090" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_388590.2" /db_xref="EnsemblGenomes-Gn:BSU07090" /db_xref="EnsemblGenomes-Tr:CAB12528" /db_xref="SubtiList:BG12861" /db_xref="UniProtKB/Swiss-Prot:O31530" /translation="MKKIKWLSGQPKVTSGVTWGMPWKKGELKKGDRLALMNENAETR YVQSEPSAYWPDGSIKWTKHAAVFGGQENQSFTVHKREVPQPTESLSILETEHDIQVD TGALVCTIHKTGSDFIQSLQINGKPIAAGGRLVAIRETRKESAAKMVLLHERSVSFIK RAAIEQSGPVKAVVKIEGVHVLHKTYEEWLPFVIRLTFYAGLSEIGLVHTQLIDRSGK LEFVKGLGIEFDLFLEGEPYNRHFRFAGEKGMYKEPAQLFGTRKFNERYPLYEKQING EMLSPDEEHKEWFAHGTQNAVWDDVKIVQDSSDHYSLSKRTGKDYAWVGMLHGSRAKG LCYAGGKNGGVALGLRYFFEKYPSALEITGLAGSRPKMTIWLWPPDGEAMDLRHYTGN THVASAYEGFDEMRSDPTGIANTNEISLACFSHMPSDEVLNALADKWQAPPLIVCEPD VYYESKALGVWSIIDTSHPLKKELEEQLDAAFLFYKKEVEQRRWYGFWHYGDVMHTYD PIRHMWRYDLGGYAWQNNELVPTLWLWQAFFRSGREDIFRMAEAMTRHTSETDSFHLG EYAGLGSRHNVVHWGCGCKEARISMAGLHKFYYYLTGDDRTGDLLTEVKDADYALVKT DPMRAFYEKGKHPTHARTGPDWAAFCSNWLAEWERTENSEYLKKIETGINCLKRLPLR LLSGPTFEYDPATSMLHHMGDGIAGGYHMIIAFGAPQVWMELAELLDDWEWEDMLSEF GEFYTLSDEEKRKKSGGALHDGHFHWPMFAAGMTAYAARKKQDPHLAAKAWNLLLEDK LSHTPLPIKPERIETWTQLEELPWVTTNTVSQWCLNVIAALELIGDSLPAKKETSGKK G*" /label="yetA CDS" gene 726411..728984 /gene="yetA" /locus_tag="BSU_07090" /old_locus_tag="BSU07090" /label="yetA gene" promotor_-10 complement(727733..727751) /Source="Nicolas_upshift_promotors" /id="U535" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.916083916083916" /psig="0.916083916083916" /xcortree=961 /SigmaFactorBS="tgtcaatgatgctccataccccgagtgcttttgaTTCGTAat agacgtccggctcGCATACAATGAGCGGGGGCgcctgccatttgtcagccagcgcatt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(727746) /Source="Nicolas_upshifts" /id="U535" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.916083916083916" /psig="0.916083916083916" /xcortree=961 /SigmaFactorBS="tgtcaatgatgctccataccccgagtgcttttgaTTCGTAat agacgtccggctcGCATACAATGAGCGGGGGCgcctgccatttgtcagccagcgcatt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(727767..727772) /Source="Nicolas_upshift_promotors" /id="U535" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.916083916083916" /psig="0.916083916083916" /xcortree=961 /SigmaFactorBS="tgtcaatgatgctccataccccgagtgcttttgaTTCGTAat agacgtccggctcGCATACAATGAGCGGGGGCgcctgccatttgtcagccagcgcatt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 729106..730614 /gene="lplA" /locus_tag="BSU_07100" /old_locus_tag="BSU07100" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7921237" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7921237; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="lipoprotein transporter binding protein for alpha-galacturonides" /protein_id="NP_388591.1" /db_xref="EnsemblGenomes-Gn:BSU07100" /db_xref="EnsemblGenomes-Tr:CAB12529" /db_xref="GOA:P37966" /db_xref="InterPro:IPR006059" /db_xref="SubtiList:BG10434" /db_xref="UniProtKB/Swiss-Prot:P37966" /translation="MKIRMRKKWMALPLAAMMIAGCSHSETSNSASGSKDTIKIMAPL LSPESPSDKSPSLKALEKYTGKEIKVTWVPDSSYNDKFNIVMASGEMPHAIVIKDKSA GFIKSVKAGAFWELSPYLKDYKNLSQADEKILKNSSVNGEVYGIYRTRDLIRACMIIR TDWLKNVGLDMPETLDDFYEVLKAFKEKDPDGNGKDDTYGMVVPKWMGLGNGSPWDVL QIWFGAPNRYGVENGKLIPDFTTKEYMDALTFFKKLYDEGLINKDFAVMDSAKWNDPV VKGKAGVIVDTGSRASQIQSAMEEADESNKDIIDIVGSLEGPNGKRTFPTSGYSGMIT IPKSSVKTEKELKEVLSFLDKMNDKEAQILTNNGVKGRNYELKDGVFTSLEKNNKSLL YEHEGLAQFSMSIPKSEYYIEDQKTKLFQHRKDIITEGEKIAVFNPAESLVSDVYTQK GAQLDNIILDARTQFIIGEIDEKGFDDAVELWKKSGGNELMKDLNKLYQSSK*" /label="lplA CDS" gene 729106..730614 /gene="lplA" /locus_tag="BSU_07100" /old_locus_tag="BSU07100" /label="lplA gene" CDS 730669..731625 /gene="lplB" /locus_tag="BSU_07110" /old_locus_tag="BSU07110" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 10869078, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (permease) for alpha-galacturonides" /protein_id="NP_388592.1" /db_xref="EnsemblGenomes-Gn:BSU07110" /db_xref="EnsemblGenomes-Tr:CAB12530" /db_xref="GOA:P39128" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG10435" /db_xref="UniProtKB/Swiss-Prot:P39128" /translation="METVPKKRDAPVLTAGKGISWMAALKRDKWLYLLLIPGLLYFLI FKYLPMWGVLIAFKDYSPYLGFWKSEWVGFDYFKDFFMNPDFFRLLRNTLMLASLDLL FAFPAPLILALLLNEVRKAVYKRCIQTFIYVPHFVSWTIVVSITFVFFTVDTGVINKL IMSLTGEQISFLSDADWFRPMIVMQSIWKETGWGTILFLAALATVDQEQYEAAIMDGA GRFRRMWHITLPAIRSTIIVLLILRIGSFLNLGFEQVYLMTNSLNRSVADIFDTYVYM MGITQGAYSYSTAVGLFKSVVGIILIFGANYIAKKFDQEGLF*" /label="lplB CDS" gene 730669..731625 /gene="lplB" /locus_tag="BSU_07110" /old_locus_tag="BSU07110" /label="lplB gene" downshifts complement(730943) /Source="Nicolas_upshifts" /id="D344" /incds=1 /nref=1 /ntot=8 /MaxReadThrough="1.59638" /MaxDrop="4.19822" /score="13.9744253" /energy="-20.3" /TU="NA" /idTUdmin="U538" /TUdmin=2068 /isTUend="FALSE" /label="downshifts" promotor_no_box complement(730969..731069) /Source="Nicolas_upshift_promotors" /id="U536" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.544455544455544" /psig="0.002997002997003" /xcortree=1476 /SigmaFactorBS="ggtacgtaaataaaggtttggatacatcttttatacacggcc tttcttacctcattcaaaagcagagccaaaatgagaggcgcgggaaaggcaaacaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(731009) /Source="Nicolas_upshifts" /id="U536" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.544455544455544" /psig="0.002997002997003" /xcortree=1476 /SigmaFactorBS="ggtacgtaaataaaggtttggatacatcttttatacacggcc tttcttacctcattcaaaagcagagccaaaatgagaggcgcgggaaaggcaaacaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 731639..732526 /gene="lplC" /locus_tag="BSU_07120" /old_locus_tag="BSU07120" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 10869078, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (permease) for alpha-galacturonides" /protein_id="NP_388593.1" /db_xref="EnsemblGenomes-Gn:BSU07120" /db_xref="EnsemblGenomes-Tr:CAB12531" /db_xref="GOA:P39129" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG10857" /db_xref="UniProtKB/Swiss-Prot:P39129" /translation="MAEIHTMHNTKAGRVFDVCNILFLGGVGAITILPFLYIIAGSFA TEAELAQRSFFIFPKTFTLDAYKYVFSTPTFLRSMGVSIFITVVGTAVQLFFTFTMAY PLAKRHVKGRNLLLNLVIFSMLFSGGMIPTYLVVKSLGLLDTYWALILPMAINPFNLI IIKNFFQQLPRELEESAKIDGCSEIGVFWRIALPLSKPVIATFALFYAVGIWNDFFHA LLYINDSAKWPLQMVLRQVTILSDLTATNGDTMQNAVPPEQGIKLAVIVIATLPILAV YPFLQKHFAKGMLIGSVKG*" /label="lplC CDS" gene 731639..732526 /gene="lplC" /locus_tag="BSU_07120" /old_locus_tag="BSU07120" /label="lplC gene" promotor_-35 732273..732278 /Source="Nicolas_upshift_promotors" /id="U537" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1069 /SigmaFactorBS="ttgcgacctttgcgctgttttatgcggtcgggatttGGAATG atttcttccacgctcTCTTATATATCAATGACAGtgcaaaatggccgctgcaaatggt g" /listShort="lplD, S248, yetF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 732294..732312 /Source="Nicolas_upshift_promotors" /id="U537" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1069 /SigmaFactorBS="ttgcgacctttgcgctgttttatgcggtcgggatttGGAATG atttcttccacgctcTCTTATATATCAATGACAGtgcaaaatggccgctgcaaatggt g" /listShort="lplD, S248, yetF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 732297 /Source="Nicolas_upshifts" /id="U537" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1069 /SigmaFactorBS="ttgcgacctttgcgctgttttatgcggtcgggatttGGAATG atttcttccacgctcTCTTATATATCAATGACAGtgcaaaatggccgctgcaaatggt g" /listShort="lplD, S248, yetF" /GFF_Attribute="listLong" /label="upshifts" CDS 732535..733875 /gene="lplD" /locus_tag="BSU_07130" /old_locus_tag="BSU07130" /EC_number="3.2.1.67" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:23416295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23416295; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alpha-galacturonidase" /protein_id="NP_388594.1" /db_xref="EnsemblGenomes-Gn:BSU07130" /db_xref="EnsemblGenomes-Tr:CAB12532" /db_xref="GOA:P39130" /db_xref="InterPro:IPR001088" /db_xref="InterPro:IPR015955" /db_xref="InterPro:IPR019802" /db_xref="InterPro:IPR022616" /db_xref="InterPro:IPR036291" /db_xref="PDB:3FEF" /db_xref="SubtiList:BG10858" /db_xref="UniProtKB/Swiss-Prot:P39130" /translation="MFHISTLDQIKIAYIGGGSQGWARSLMSDLSIDERMSGTVALYD LDFEAAQKNEVIGNHSGNGRWRYEAVSTLKKALSAADIVIISILPGSLDDMEVDVHLP ERCGIYQSVGDTVGPGGIIRGLRAVPIFAEIARAIRDYAPESWVINYTNPMSVCTRVL YKVFPGIKAIGCCHEVFGTQKLLAEMVTERLGIEVPRREDIRVNVLGINHFTWITKAS YRHIDLLPIFREFSAHYGESGYELEGECWRDSVFCSAHRVAFDLFETYGAIPAAGDRH LAEFLPGPYLKQPEVWKFHLTPISFRKQDRAEKRQETERLIVQQRGVAEKASGEEGVN IIAALLGLGELVTNVNMPNQGQVLNLPIQAIVETNAFITRNRVQPILSGALPKGVEML AARHISNQEAVADAGLTKDTGLAFQAFLNDPLVQIDRSDAEQLFNDMLQCIMQS*" /label="lplD CDS" gene 732535..733875 /gene="lplD" /locus_tag="BSU_07130" /old_locus_tag="BSU07130" /label="lplD gene" S_feature complement(732969..734660) /Source="Nicolas_S_feature" /locus_tag="new_783392_785083_c" /HighExp="H2O2, dia15, Paraq, Lbexp, LBGexp, Salt, LPhT, GM 25, G150, dia0" /AntisenseName="yetF" /AntisenseCor="-0.25986434675098202" /AntisenseRegPval="-4.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigA" /TUlongPSig="0.993" /label="S247" S_feature 733876..733957 /Source="Nicolas_S_feature" /locus_tag="new_784299_784380" /HighExp="S5, S4, S6, S3, S7, S8, BT, LoTm, B36, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S248" CDS 733958..734653 /gene="yetF" /locus_tag="BSU_07140" /old_locus_tag="BSU07140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="conserved membrane protein" /protein_id="NP_388595.1" /db_xref="EnsemblGenomes-Gn:BSU07140" /db_xref="EnsemblGenomes-Tr:CAB12533" /db_xref="GOA:O31533" /db_xref="InterPro:IPR007353" /db_xref="InterPro:IPR023090" /db_xref="PDB:3C6F" /db_xref="SubtiList:BG12862" /db_xref="UniProtKB/Swiss-Prot:O31533" /translation="MGNYLSVAVELVCGLGILFIILKLLGKTQFSQITPFDFISALIL GELVGNAVYDHEIKIKEIIFASLLWGVLIYIIEFITQKMKSSRKFLEGEPNIVIRKGE LQYKVMKKNKIDINQLQSLLRQAGSFSIQEVEYAILETNGMVSVLPKSDFDKPTNKDL QIPSKSVSLPITLIIDGEIVRDNLKEAGVDEQWLKQELKKKNIDKTEDVLFAEWHKNK PLYTVTYEQSRST*" /label="yetF CDS" gene 733958..734653 /gene="yetF" /locus_tag="BSU_07140" /old_locus_tag="BSU07140" /label="yetF gene" downshifts 734651 /Source="Nicolas_upshifts" /id="D345" /incds=0 /nref=2 /ntot=24 /MaxReadThrough="1.32891" /MaxDrop="3.45213" /score="-0.176154378" /energy="-7.1" /TU="NA" /idTUdmin="U537" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(734690..735016) /gene="hmoA" /locus_tag="BSU_07150" /old_locus_tag="BSU07150" /EC_number="1.14.14.18" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:20180905, 21764939, 21873409" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20180905, 21764939, 21873409; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="heme-degrading monooxygenase" /protein_id="NP_388596.2" /db_xref="EnsemblGenomes-Gn:BSU07150" /db_xref="EnsemblGenomes-Tr:CAB12534" /db_xref="GOA:O31534" /db_xref="InterPro:IPR007138" /db_xref="InterPro:IPR011008" /db_xref="SubtiList:BG12863" /db_xref="UniProtKB/Swiss-Prot:O31534" /translation="MFVQLRKMTVKEGFADKVIERFSAEGIIEKQEGLIDVTVLEKNV RRGDEEVVVMIRWESEDHWKQWEKSDAHIAGHKANKGKPKPDYLISTEVSMYHVRAVK QGTYNQ*" /label="hmoA CDS" gene complement(734690..735016) /gene="hmoA" /locus_tag="BSU_07150" /old_locus_tag="BSU07150" /label="hmoA gene" downshifts complement(734705) /Source="Nicolas_upshifts" /id="D346" /incds=0 /nref=194 /ntot=248 /MaxReadThrough="4.01189" /MaxDrop="6.29183" /score="9.23596913" /energy="-9.1" /TU="U538" /idTUdmin="U539" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 735003 /Source="Nicolas_upshifts" /id="D347" /incds=1 /nref=1 /ntot=45 /MaxReadThrough="1.96802" /MaxDrop="3.46057" /score="-7.34187128" /energy="-5" /TU="NA" /idTUdmin="U537" /TUdmin=352 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(735039..735058) /Source="Nicolas_upshift_promotors" /id="U538" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.604395604395604" /psig="0.999000999001" /xcortree=2117 /SigmaFactorBS="tgttgcgcacggcggttcgattccgccctgcgctttcTTTGA CATtgagaatgaatttcATTTACAATTATTCATATGTgagaatgattggagtgagaca a" /listShort="yetG, S247" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(735057) /Source="Nicolas_upshifts" /id="U538" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.604395604395604" /psig="0.999000999001" /xcortree=2117 /SigmaFactorBS="tgttgcgcacggcggttcgattccgccctgcgctttcTTTGA CATtgagaatgaatttcATTTACAATTATTCATATGTgagaatgattggagtgagaca a" /listShort="yetG, S247" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(735073..735080) /Source="Nicolas_upshift_promotors" /id="U538" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.604395604395604" /psig="0.999000999001" /xcortree=2117 /SigmaFactorBS="tgttgcgcacggcggttcgattccgccctgcgctttcTTTGA CATtgagaatgaatttcATTTACAATTATTCATATGTgagaatgattggagtgagaca a" /listShort="yetG, S247" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(735120..735482) /gene="yetH" /locus_tag="BSU_07160" /old_locus_tag="BSU07160" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lyase/dioxygenase" /protein_id="NP_388597.1" /db_xref="EnsemblGenomes-Gn:BSU07160" /db_xref="EnsemblGenomes-Tr:CAB12535" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG12864" /db_xref="UniProtKB/Swiss-Prot:O31535" /translation="MIKQIGTVAVYVEDQQKAKQFWTEKVGFDIAADHPMGPEASWLE VAPKGAETRLVIYPKAMMKGSEQMKASIVFECEDIFGTYEKMKTNGVEFLGEPNQMEW GTFVQFKDEDGNVFLLKE*" /label="yetH CDS" gene complement(735120..735482) /gene="yetH" /locus_tag="BSU_07160" /old_locus_tag="BSU07160" /label="yetH gene" promotor_-10 complement(735505..735524) /Source="Nicolas_upshift_promotors" /id="U539" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.431568431568432" /psig="0.993006993006993" /xcortree=2376 /SigmaFactorBS="ttttaataatcagccggtttcccggctgatttttttATGTTA CttcggccgtaaaCAGGTTATAGTATTATTATCttttcaacttggaggtttccctatg a" /listShort="yetH, yetG" /listLong="S247" /label="promotor_-10" upshifts complement(735519) /Source="Nicolas_upshifts" /id="U539" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.431568431568432" /psig="0.993006993006993" /xcortree=2376 /SigmaFactorBS="ttttaataatcagccggtttcccggctgatttttttATGTTA CttcggccgtaaaCAGGTTATAGTATTATTATCttttcaacttggaggtttccctatg a" /listShort="yetH, yetG" /listLong="S247" /label="upshifts" promotor_-35 complement(735537..735543) /Source="Nicolas_upshift_promotors" /id="U539" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.431568431568432" /psig="0.993006993006993" /xcortree=2376 /SigmaFactorBS="ttttaataatcagccggtttcccggctgatttttttATGTTA CttcggccgtaaaCAGGTTATAGTATTATTATCttttcaacttggaggtttccctatg a" /listShort="yetH, yetG" /listLong="S247" /label="promotor_-35" S_feature complement(735553..736113) /Source="Nicolas_S_feature" /locus_tag="new_785976_786536_c" /HighExp="S8, S6, S7, S5, BT, B36, G/S, B60, Pyr, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99999400000000005" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S249" downshifts complement(735585) /Source="Nicolas_upshifts" /id="D348" /incds=0 /nref=38 /ntot=47 /MaxReadThrough="0.395850000000001" /MaxDrop="8.2984" /score="45.4672528" /energy="-13.7" /TU="NA" /idTUdmin="U540" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(736096..736115) /Source="Nicolas_upshift_promotors" /id="U540" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1291 /SigmaFactorBS="ctctctgagagcattccagcttcatatccttaggcGAATGCA CCAataagagtccgccCGCATAAACTGCAATGTACAgtttacaatgagaaaggacgtt a" /listShort="S249" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(736113) /Source="Nicolas_upshifts" /id="U540" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1291 /SigmaFactorBS="ctctctgagagcattccagcttcatatccttaggcGAATGCA CCAataagagtccgccCGCATAAACTGCAATGTACAgtttacaatgagaaaggacgtt a" /listShort="S249" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(736129..736138) /Source="Nicolas_upshift_promotors" /id="U540" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1291 /SigmaFactorBS="ctctctgagagcattccagcttcatatccttaggcGAATGCA CCAataagagtccgccCGCATAAACTGCAATGTACAgtttacaatgagaaaggacgtt a" /listShort="S249" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 736201..736208 /Source="Nicolas_upshift_promotors" /id="U541" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.915084915084915" /psig="0.999000999001" /xcortree=2437 /SigmaFactorBS="ggaatgctctcagagagcagaatcatttgatttttctctagt ctTATTCACAattccgatttatCATTTTATAATGAAAGTGCTtctattacgaaaaagg a" /listShort="yetI, yetI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 736217 /Source="Nicolas_upshifts" /id="U541" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.915084915084915" /psig="0.999000999001" /xcortree=2437 /SigmaFactorBS="ggaatgctctcagagagcagaatcatttgatttttctctagt ctTATTCACAattccgatttatCATTTTATAATGAAAGTGCTtctattacgaaaaagg a" /listShort="yetI, yetI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 736221..736240 /Source="Nicolas_upshift_promotors" /id="U541" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.915084915084915" /psig="0.999000999001" /xcortree=2437 /SigmaFactorBS="ggaatgctctcagagagcagaatcatttgatttttctctagt ctTATTCACAattccgatttatCATTTTATAATGAAAGTGCTtctattacgaaaaagg a" /listShort="yetI, yetI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 736266..736847 /gene="yetI" /locus_tag="BSU_07170" /old_locus_tag="BSU07170" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 11157946; Product type r: regulator" /pseudo /codon_start=1 /transl_table=11 /product="putative paralog of RsbR; N-terminal part of YetI" /db_xref="SubtiList:BG12865" /translation="MNIDQLLYQYIIDNTADITEKWFSLRCQLKGELYSASHLSEETK TLLTEQHTFTNITIASAFLEDQTDFQENMTKWAQNVAKNRVEQDVQVHEVVEAISNSR ISFWDAVATFIKENQEIVTNEDADRWNRIVNQSFDKLIIEFSEQYQKFMLMRLTSQQE LISELGCPVISIADGIGILPLIGSIDTKRHRSF*" /label="yetI CDS" gene 736266..736847 /gene="yetI" /locus_tag="BSU_07170" /old_locus_tag="BSU07170" /pseudo /label="yetI gene" CDS 736841..737137 /gene="yetI" /locus_tag="BSU_07180" /old_locus_tag="BSU07180" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 11157946; Product type r: regulator" /pseudo /codon_start=1 /transl_table=11 /product="putative paralog of RsbR; C-terminal part of YetI" /db_xref="GOA:O31537" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR036513" /db_xref="PSEUDO:CAB12537.2" /db_xref="SubtiList:BG12873" /db_xref="UniProtKB/Swiss-Prot:O31537" /translation="MLETVPVRCVERKITSLVVDLSGVPIVDTMVAQQLYNLSKTLFL LGVKAVFSGIRPDVAQTSIQLGLDFSEYETYGTLKQALENMGVRCIVEELEENK*" /label="yetI CDS" gene 736841..737137 /gene="yetI" /locus_tag="BSU_07180" /old_locus_tag="BSU07180" /pseudo /label="yetI gene" downshifts 737129 /Source="Nicolas_upshifts" /id="D349" /incds=0 /nref=114 /ntot=215 /MaxReadThrough="1.06939" /MaxDrop="4.8053" /score="16.356572" /energy="-21.2" /TU="NA" /idTUdmin="U541" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" promotor_-35 737208..737215 /Source="Nicolas_upshift_promotors" /id="U542" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.603396603396603" /psig=1 /xcortree=1743 /SigmaFactorBS="atatgcctttttgatttgaacagaaatcaccATTGATTTatc gaaaaaaacaTAATATTATAATTCTTATAAgaatactgtgaattaaaacctattcaac a" /listShort="yezD, yetJ, yetK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 737229..737248 /Source="Nicolas_upshift_promotors" /id="U542" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.603396603396603" /psig=1 /xcortree=1743 /SigmaFactorBS="atatgcctttttgatttgaacagaaatcaccATTGATTTatc gaaaaaaacaTAATATTATAATTCTTATAAgaatactgtgaattaaaacctattcaac a" /listShort="yezD, yetJ, yetK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 737237 /Source="Nicolas_upshifts" /id="U542" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.603396603396603" /psig=1 /xcortree=1743 /SigmaFactorBS="atatgcctttttgatttgaacagaaatcaccATTGATTTatc gaaaaaaacaTAATATTATAATTCTTATAAgaatactgtgaattaaaacctattcaac a" /listShort="yezD, yetJ, yetK" /GFF_Attribute="listLong" /label="upshifts" CDS 737292..737459 /gene="yezD" /locus_tag="BSU_07190" /old_locus_tag="BSU07190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388600.1" /db_xref="EnsemblGenomes-Gn:BSU07190" /db_xref="EnsemblGenomes-Tr:CAB12538" /db_xref="InterPro:IPR018743" /db_xref="SubtiList:BG12875" /db_xref="UniProtKB/Swiss-Prot:O31538" /translation="MVSKSTIDPEVIEKIISSLETLDFGTVQITVHDSQITQIEKIEK HRFSLKRKESK*" /label="yezD CDS" gene 737292..737459 /gene="yezD" /locus_tag="BSU_07190" /old_locus_tag="BSU07190" /label="yezD gene" promotor_-35 737501..737508 /Source="Nicolas_upshift_promotors" /id="U543" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2401 /SigmaFactorBS="taaagggcgtttgttttcattaaattctccttaaaaCATATA CAtatttcatccaatttTTATATAATAGACCTTTAAGatcattttttaggaggatttt t" /listShort="yetJ, yetK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 737524..737543 /Source="Nicolas_upshift_promotors" /id="U543" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2401 /SigmaFactorBS="taaagggcgtttgttttcattaaattctccttaaaaCATATA CAtatttcatccaatttTTATATAATAGACCTTTAAGatcattttttaggaggatttt t" /listShort="yetJ, yetK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 737525 /Source="Nicolas_upshifts" /id="U543" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2401 /SigmaFactorBS="taaagggcgtttgttttcattaaattctccttaaaaCATATA CAtatttcatccaatttTTATATAATAGACCTTTAAGatcattttttaggaggatttt t" /listShort="yetJ, yetK" /GFF_Attribute="listLong" /label="upshifts" CDS 737569..738213 /gene="calJ" /locus_tag="BSU_07200" /old_locus_tag="BSU07200" /function="7.4: Cations and iron carrying compounds" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 16086852, 24904158" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 16086852, 24904158; Product type t: transporter" /codon_start=1 /transl_table=11 /product="pH-sensitive calcium-leak permease (di-aspartyl pH sensor)" /protein_id="NP_388601.1" /db_xref="EnsemblGenomes-Gn:BSU07200" /db_xref="EnsemblGenomes-Tr:CAB12539" /db_xref="GOA:O31539" /db_xref="InterPro:IPR006214" /db_xref="PDB:4PGR" /db_xref="PDB:4PGS" /db_xref="PDB:4PGU" /db_xref="PDB:4PGV" /db_xref="PDB:4PGW" /db_xref="PDB:4TKQ" /db_xref="SubtiList:BG12866" /db_xref="UniProtKB/Swiss-Prot:O31539" /translation="MQATVHESKQSIMQRILTVFVFTLLIATVGLFIGQFVPVALMLP LSILEVAMIILAFWMRRRKAVGYAFVYTFAFVSGITLFPIVSHYASIAGAYVVLEAFG STFVIFAVLGTIGAKMKKDLSFLWSFLLVAVLALAVVGIFNIFSPLNSAAMMAYSVIG TIVFSLYILYDLNQIKHRHITEDLIPVMALSLYLDFINLFINLLRFFGILSSDD*" /label="calJ CDS" gene 737569..738213 /gene="calJ" /locus_tag="BSU_07200" /old_locus_tag="BSU07200" /label="calJ gene" downshifts 738149 /Source="Nicolas_upshifts" /id="D350" /incds=1 /nref=1 /ntot=11 /MaxReadThrough="6.69003" /MaxDrop="2.5446" /score="-1.46791202" /energy="-10.7" /TU="U542,U543" /idTUdmin="U541" /TUdmin=1012 /isTUend="FALSE" /label="downshifts" downshifts 738193 /Source="Nicolas_upshifts" /id="D351" /incds=0 /nref=7 /ntot=127 /MaxReadThrough="5.33515" /MaxDrop="3.71552" /score="-1.46791202" /energy="-10.7" /TU="U542,U543" /idTUdmin="U542" /TUdmin="-990" /isTUend="FALSE" /label="downshifts" CDS 738213..739205 /gene="yetK" /locus_tag="BSU_07210" /old_locus_tag="BSU07210" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388602.1" /db_xref="EnsemblGenomes-Gn:BSU07210" /db_xref="EnsemblGenomes-Tr:CAB12540" /db_xref="GOA:O31540" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG12867" /db_xref="UniProtKB/Swiss-Prot:O31540" /translation="MKKRLSLDRRFLPYIKKAGGVLVKKQMGAYVSLAAAMAIVGSSV VVGKLMVERIPVFLSSGLRFLIASVVLLMLLFCIEKGFPALTKKDVFVLLVQSFTGVF LFSICLLYGVQYTTGTESGILTSTTPMLIGILSFFLLREKIEKKTLIGILLAVCGVMA INLFGAGSQDGTPHALFGNMLIIAAVIGEALFTLMAKLLSPHISALAISTFVSLFGFL FFLPFALFEASSFDYSVPTVLDWSYVLYYALFVTVLAFYLWYSGVTKVPAGVSGIFTS VLPVSAVILSGVILKEPFEFVHFIGIACVIGGIFVTVIKKKQPDAYPAAEEKTL*" /label="yetK CDS" gene 738213..739205 /gene="yetK" /locus_tag="BSU_07210" /old_locus_tag="BSU07210" /label="yetK gene" downshifts 739139 /Source="Nicolas_upshifts" /id="D352" /incds=1 /nref=1 /ntot=18 /MaxReadThrough="4.14475" /MaxDrop="2.73453" /score="21.8095329" /energy="-10.7" /TU="U542,U543" /idTUdmin="U542" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" downshifts 739183 /Source="Nicolas_upshifts" /id="D353" /incds=0 /nref=94 /ntot=214 /MaxReadThrough="0.120229999999999" /MaxDrop="4.45909" /score="21.8095329" /energy="-10.7" /TU="NA" /idTUdmin="U542" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(739229..739732) /gene="flvL" /locus_tag="BSU_07220" /old_locus_tag="BSU07220" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:19329649, 25209494" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19329649, 25209494; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (FlvL-flavonoids)" /protein_id="NP_388603.1" /db_xref="EnsemblGenomes-Gn:BSU07220" /db_xref="EnsemblGenomes-Tr:CAB12541" /db_xref="GOA:O31541" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12868" /db_xref="UniProtKB/Swiss-Prot:O31541" /translation="MELKHLPKYKHITEHAETYANIDAGSLELFLSLFDISKKMNHVM EHYFAGRGLSEGKFKILMLLFDAKDHRLSPTELAKRSNVTKATITGLLDGLARDGFVS RRHHTEDKRKISIELTTEGKARLEQFLPGHFSKISAVMENYSDEEKDMFVKMLGDLFE RLSVFKD*" /label="flvL CDS" gene complement(739229..739732) /gene="flvL" /locus_tag="BSU_07220" /old_locus_tag="BSU07220" /label="flvL gene" promotor_-10 complement(739757..739776) /Source="Nicolas_upshift_promotors" /id="U544" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.739260739260739" /psig="0.952047952047952" /xcortree=3006 /SigmaFactorBS="aagaaaagctgtcaatcatctccaagccAAGTTGCGttatgg ttttcccTCCTTTATAATCGTGTCACAacgaatgtacgggagctaattgcgatggaat t" /listShort="yetL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(739765) /Source="Nicolas_upshifts" /id="U544" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.739260739260739" /psig="0.952047952047952" /xcortree=3006 /SigmaFactorBS="aagaaaagctgtcaatcatctccaagccAAGTTGCGttatgg ttttcccTCCTTTATAATCGTGTCACAacgaatgtacgggagctaattgcgatggaat t" /listShort="yetL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(739790..739797) /Source="Nicolas_upshift_promotors" /id="U544" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.739260739260739" /psig="0.952047952047952" /xcortree=3006 /SigmaFactorBS="aagaaaagctgtcaatcatctccaagccAAGTTGCGttatgg ttttcccTCCTTTATAATCGTGTCACAacgaatgtacgggagctaattgcgatggaat t" /listShort="yetL" /GFF_Attribute="listLong" /label="promotor_-35" CDS 739895..741004 /gene="flvM" /locus_tag="BSU_07230" /old_locus_tag="BSU07230" /EC_number="1.14.13.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 25209494; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative flavin-dependent hydroxylase/monooxygenase acting on salicylate derivatives" /protein_id="NP_388604.1" /db_xref="EnsemblGenomes-Gn:BSU07230" /db_xref="EnsemblGenomes-Tr:CAB12542" /db_xref="GOA:O06489" /db_xref="InterPro:IPR002938" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG12869" /db_xref="UniProtKB/Swiss-Prot:O06489" /translation="MKHMLIAGGGIGGLSAAISLRKAGFSVTLCEAASENRKTGAGIL QPQNALAVLKELGVFEDCCKHGFQTEWFKTFDEQGNLLFQVSESFLDDSLPGRNNILR KTLNDILMKHAEAVGVDIKWGKKVVAYEETAESVTALCEDGEKMQADILAGFDGIHSV VRDKMLQKETEKEHLGMGAWRFYIELPDYTFEDATFMYRSGDTQIGVVPLAQHAGYVF VLQPCTSDYWDEEDTRFDRVKEILSGFRGLDFVTKHMSKQHPVIFNKLEQVAVQEPWH KGRVIIGGDAAHAGAPTLAQGAAMAIEDAIVLAEELQNHADHETALQAYYKRRAPRAL KVQNLSSEIVRRRLKGEPGAEELIGECYAVLREGY*" /label="flvM CDS" gene 739895..741004 /gene="flvM" /locus_tag="BSU_07230" /old_locus_tag="BSU07230" /label="flvM gene" downshifts 740987 /Source="Nicolas_upshifts" /id="D354" /incds=0 /nref=7 /ntot=67 /MaxReadThrough="0.0953400000000002" /MaxDrop="5.1482" /score="13.261567" /energy="-12.6" /TU="NA" /idTUdmin="U542" /TUdmin=1804 /isTUend="FALSE" /label="downshifts" CDS complement(741039..742109) /gene="yetN" /locus_tag="BSU_07240" /old_locus_tag="BSU07240" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22333191" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388605.1" /db_xref="EnsemblGenomes-Gn:BSU07240" /db_xref="EnsemblGenomes-Tr:CAB12543" /db_xref="InterPro:IPR025006" /db_xref="InterPro:IPR025012" /db_xref="SubtiList:BG12870" /db_xref="UniProtKB/Swiss-Prot:O06490" /translation="MDFEIRFLSFYVIQVEGKDEQANKQFKHFQTLDTGEFEESELKD FLDGELKKIVKRKADRHPQSEQVPTKIGHFIVEPGHELDSNPNYNMFNRARLAETKED FNELSEQFVRTYLDTSAVRGGVFLVASAVPRKYFDESFVFIMKCDFEPKVARISDASS LIKKVEMAITTKNMKSIQYPYMPEEGMVEEGELKIHQASHARYFEDFLKFVEYGESMP EIMKNQVMNMVQEHVYETFEDNSEELKQFEHDIEIWEASEKREIQERLDTHQVIEASA QIIEHTPEAQLKMKVGETEIKGLLADFGDSIHLAKVNGRYVALIEAETISFEKGSSPV EFYKPEGLHEVIERIRNKTEQD*" /label="yetN CDS" gene complement(741039..742109) /gene="yetN" /locus_tag="BSU_07240" /old_locus_tag="BSU07240" /label="yetN gene" downshifts complement(741063) /Source="Nicolas_upshifts" /id="D355" /incds=0 /nref=45 /ntot=180 /MaxReadThrough="0.83729" /MaxDrop="4.28938" /score="0.323038441" /energy="-11.6" /TU="NA" /idTUdmin="U545" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(742140..742159) /Source="Nicolas_upshift_promotors" /id="U545" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.818181818181818" /psig="0.987012987012987" /xcortree=1835 /SigmaFactorBS="atttgactacatttccctttcatggtcatgattattccgttc tccCAATTGACgcatgatcgctgttTTTTCTATACTTGAGAAGCTgtacaatacgcga a" /listShort="yetN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(742166) /Source="Nicolas_upshifts" /id="U545" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.818181818181818" /psig="0.987012987012987" /xcortree=1835 /SigmaFactorBS="atttgactacatttccctttcatggtcatgattattccgttc tccCAATTGACgcatgatcgctgttTTTTCTATACTTGAGAAGCTgtacaatacgcga a" /listShort="yetN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(742174..742181) /Source="Nicolas_upshift_promotors" /id="U545" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.818181818181818" /psig="0.987012987012987" /xcortree=1835 /SigmaFactorBS="atttgactacatttccctttcatggtcatgattattccgttc tccCAATTGACgcatgatcgctgttTTTTCTATACTTGAGAAGCTgtacaatacgcga a" /listShort="yetN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 742189..742195 /Source="Nicolas_upshift_promotors" /id="U546" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=728 /SigmaFactorBS="aaacagcgatcatgcgtcaattgggagaacGGAATAAtcatg accatgaaaGGGAAATGTAGTCAAATAGaaggcatttcatacggaaaggaatggttcg a" /listShort="yetO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 742210..742228 /Source="Nicolas_upshift_promotors" /id="U546" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=728 /SigmaFactorBS="aaacagcgatcatgcgtcaattgggagaacGGAATAAtcatg accatgaaaGGGAAATGTAGTCAAATAGaaggcatttcatacggaaaggaatggttcg a" /listShort="yetO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 742219 /Source="Nicolas_upshifts" /id="U546" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=728 /SigmaFactorBS="aaacagcgatcatgcgtcaattgggagaacGGAATAAtcatg accatgaaaGGGAAATGTAGTCAAATAGaaggcatttcatacggaaaggaatggttcg a" /listShort="yetO" /GFF_Attribute="listLong" /label="upshifts" CDS 742259..745444 /gene="cypD" /locus_tag="BSU_07250" /old_locus_tag="BSU07250" /EC_number="1.6.2.4" /EC_number="1.14.14.1" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11574077, 2544578, 21048857, 26452461; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional P-450/NADPH-P450 reductase 1" /protein_id="NP_388606.1" /db_xref="EnsemblGenomes-Gn:BSU07250" /db_xref="EnsemblGenomes-Tr:CAB12544" /db_xref="GOA:O08394" /db_xref="InterPro:IPR001094" /db_xref="InterPro:IPR001128" /db_xref="InterPro:IPR001433" /db_xref="InterPro:IPR001709" /db_xref="InterPro:IPR003097" /db_xref="InterPro:IPR008254" /db_xref="InterPro:IPR017927" /db_xref="InterPro:IPR017938" /db_xref="InterPro:IPR017972" /db_xref="InterPro:IPR023206" /db_xref="InterPro:IPR029039" /db_xref="InterPro:IPR036396" /db_xref="SubtiList:BG12871" /db_xref="UniProtKB/Swiss-Prot:O08394" /translation="MKETSPIPQPKTFGPLGNLPLIDKDKPTLSLIKLAEEQGPIFQI HTPAGTTIVVSGHELVKEVCDEERFDKSIEGALEKVRAFSGDGLFTSWTHEPNWRKAH NILMPTFSQRAMKDYHEKMVDIAVQLIQKWARLNPNEAVDVPGDMTRLTLDTIGLCGF NYRFNSYYRETPHPFINSMVRALDEAMHQMQRLDVQDKLMVRTKRQFRYDIQTMFSLV DSIIAERRANGDQDEKDLLARMLNVEDPETGEKLDDENIRFQIITFLIAGHETTSGLL SFATYFLLKHPDKLKKAYEEVDRVLTDAAPTYKQVLELTYIRMILNESLRLWPTAPAF SLYPKEDTVIGGKFPITTNDRISVLIPQLHRDRDAWGKDAEEFRPERFEHQDQVPHHA YKPFGNGQRACIGMQFALHEATLVLGMILKYFTLIDHENYELDIKQTLTLKPGDFHIS VQSRHQEAIHADVQAAEKAAPDEQKEKTEAKGASVIGLNNRPLLVLYGSDTGTAEGVA RELADTASLHGVRTKTAPLNDRIGKLPKEGAVVIVTSSYNGKPPSNAGQFVQWLQEIK PGELEGVHYAVFGCGDHNWASTYQYVPRFIDEQLAEKGATRFSARGEGDVSGDFEGQL DEWKKSMWADAIKAFGLELNENADKERSTLSLQFVRGLGESPLARSYEASHASIAENR ELQSADSDRSTRHIEIALPPDVEYQEGDHLGVLPKNSQTNVSRILHRFGLKGTDQVTL SASGRSAGHLPLGRPVSLHDLLSYSVEVQEAATRAQIRELASFTVCPPHRRELEELSA EGVYQEQILKKRISMLDLLEKYEACDMPFERFLELLRPLKPRYYSISSSPRVNPRQAS ITVGVVRGPAWSGRGEYRGVASNDLAERQAGDDVVMFIRTPESRFQLPKDPETPIIMV GPGTGVAPFRGFLQARDVLKREGKTLGEAHLYFGCRNDRDFIYRDELERFEKDGIVTV HTAFSRKEGMPKTYVQHLMADQADTLISILDRGGRLYVCGDGSKMAPDVEAALQKAYQ AVHGTGEQEAQNWLRHLQDTGMYAKDVWAGI*" /label="cypD CDS" gene 742259..745444 /gene="cypD" /locus_tag="BSU_07250" /old_locus_tag="BSU07250" /label="cypD gene" downshifts 745431 /Source="Nicolas_upshifts" /id="D356" /incds=0 /nref=1 /ntot=9 /MaxReadThrough="2.31156" /MaxDrop="2.91666" /score="9.17315362" /energy="-9.8" /TU="NA" /idTUdmin="U546" /TUdmin=44 /isTUend="FALSE" /label="downshifts" promotor_-35 745494..745499 /Source="Nicolas_upshift_promotors" /id="U547" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.841158841158841" /psig="0.841158841158841" /xcortree=1029 /SigmaFactorBS="agtcctttcgaaaaaatgGTGATCgcgctaaacattgatGCA TACAATAACTTCAGTCcgccggaagggcgggctgtctgcaaaacctatttttcgtttt t" /listShort="S250, ltaSA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 745515..745533 /Source="Nicolas_upshift_promotors" /id="U547" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.841158841158841" /psig="0.841158841158841" /xcortree=1029 /SigmaFactorBS="agtcctttcgaaaaaatgGTGATCgcgctaaacattgatGCA TACAATAACTTCAGTCcgccggaagggcgggctgtctgcaaaacctatttttcgtttt t" /listShort="S250, ltaSA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 745536 /Source="Nicolas_upshifts" /id="U547" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.841158841158841" /psig="0.841158841158841" /xcortree=1029 /SigmaFactorBS="agtcctttcgaaaaaatgGTGATCgcgctaaacattgatGCA TACAATAACTTCAGTCcgccggaagggcgggctgtctgcaaaacctatttttcgtttt t" /listShort="S250, ltaSA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 745564..745567 /Source="Nicolas_upshift_promotors" /id="U548" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.803196803196803" /psig=1 /xcortree=2603 /SigmaFactorBS="acttcagtccgccggaagggcgggctgtctgcaaaacctATT TttcgtttttgctagttTATGTTATTCTTATACTCGGtatctatttcttttttcaaag g" /listShort="S250, ltaSA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 745584..745603 /Source="Nicolas_upshift_promotors" /id="U548" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.803196803196803" /psig=1 /xcortree=2603 /SigmaFactorBS="acttcagtccgccggaagggcgggctgtctgcaaaacctATT TttcgtttttgctagttTATGTTATTCTTATACTCGGtatctatttcttttttcaaag g" /listShort="S250, ltaSA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 745585..745890 /Source="Nicolas_S_feature" /locus_tag="new_796008_796313" /HighExp="H2O2, Paraq, Oxctl, Cold, Heat, LBGexp, G180, G150, HPh, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 0.841" /TUlongSig="NA" /TUlongPSig="NA" /label="S250" upshifts 745585 /Source="Nicolas_upshifts" /id="U548" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.803196803196803" /psig=1 /xcortree=2603 /SigmaFactorBS="acttcagtccgccggaagggcgggctgtctgcaaaacctATT TttcgtttttgctagttTATGTTATTCTTATACTCGGtatctatttcttttttcaaag g" /listShort="S250, ltaSA" /GFF_Attribute="listLong" /label="upshifts" CDS 745891..747810 /gene="ltaSA" /locus_tag="BSU_07260" /old_locus_tag="BSU07260" /function="16.1: Circulate" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11544192, 15187182, 17434969, 17483484, 21255105, 27002131; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="exported glycerol phosphate lipoteichoic acid synthetase and anion-binding protein" /protein_id="NP_388607.2" /db_xref="EnsemblGenomes-Gn:BSU07260" /db_xref="EnsemblGenomes-Tr:CAB12545" /db_xref="GOA:Q797B3" /db_xref="InterPro:IPR000917" /db_xref="InterPro:IPR012160" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="SubtiList:BG12980" /db_xref="UniProtKB/Swiss-Prot:Q797B3" /translation="MKKLFSYKLSFFVLAVILFWAKTYLSYKTEFNLGVKGTTQEILL IFNPFSSAVFFLGLALLAKGRKSAIIMLIIDFLMTFVLYANILFYRFFDDFLTFPNIK QSGNVGNMGDGIFSIMAGHDIFYFLDIIILIAVLIWRPELKEYKMKKRFASLVILSGI ALFFINLHYAEKDRPQLLTRTFDRNYIVKYLGLYNYTIYDGVQTAQTETQRAYASSDD LTSVENYTTSHYAKPNAEYFGSAKGKNIIKIHLESFQSFLIDYKLNGEEVTPFLNKLA HGGEDVTYFDNFFHQTGQGKTSDAELTMDNSIFGLPEGSAFVTKGENTYQSLPAILDQ KEGYTSAVLHGDYKSFWNRDQIYKHIGYDKFFDASTYDMSDENVINMGLKDKPFFTES IPKLESLKQPFYAHLITLTNHYPFNLDEKDASLKKATTGDNTVDSYFQTARYLDEALE QFFKELKEAGLYDNSVIMIYGDHNGISENHNRAMKEILGKEITDYQNAQNQRVPLMIR VPGKKGGVNHTYGGEIDVMPTLLHLEGIDSQKYINFGTDLFSKDHDDTVAFRNGDFVT PKYTSVDNIIYDTKTGEKLKANEETKNLKTRVNQQLSLSDSVLYKDLLRFHKLNDFKA VDPSDYHYGKEKEIK*" /label="ltaSA CDS" gene 745891..747810 /gene="ltaSA" /locus_tag="BSU_07260" /old_locus_tag="BSU07260" /label="ltaSA gene" downshifts 747809 /Source="Nicolas_upshifts" /id="D357" /incds=0 /nref=103 /ntot=261 /MaxReadThrough="1.69168" /MaxDrop="7.8227" /score="37.7648461" /energy="-24" /TU="NA" /idTUdmin="U547" /TUdmin=2 /isTUend="TRUE" /label="downshifts" promotor_-35 747898..747907 /Source="Nicolas_upshift_promotors" /id="U549" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1421 /SigmaFactorBS="tttttttggttatacaaccaacttgaaaaaatagattccatT TGGTCACCAaggctggctttctCTCATATCATTACAGTAGATtttgaaaccggattga a" /listShort="S251, yfnH, yfnG, yfnF, yfnE, yfnD" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 747917..748045 /Source="Nicolas_S_feature" /locus_tag="new_798340_798468" /HighExp="BT, B36, S8, S7, G/S, Pyr, B60, S6, Glucon, MG 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S251" upshifts 747917 /Source="Nicolas_upshifts" /id="U549" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1421 /SigmaFactorBS="tttttttggttatacaaccaacttgaaaaaatagattccatT TGGTCACCAaggctggctttctCTCATATCATTACAGTAGATtttgaaaccggattga a" /listShort="S251, yfnH, yfnG, yfnF, yfnE, yfnD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 747921..747940 /Source="Nicolas_upshift_promotors" /id="U549" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1421 /SigmaFactorBS="tttttttggttatacaaccaacttgaaaaaatagattccatT TGGTCACCAaggctggctttctCTCATATCATTACAGTAGATtttgaaaccggattga a" /listShort="S251, yfnH, yfnG, yfnF, yfnE, yfnD" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(747971) /Source="Nicolas_upshifts" /id="D358" /incds=0 /nref=2 /ntot=6 /MaxReadThrough="1.80969" /MaxDrop="4.63324" /score="20.6569889" /energy="-23.4" /TU="NA" /idTUdmin="U552" /TUdmin=4928 /isTUend="FALSE" /label="downshifts" CDS 748046..748810 /gene="spmH" /locus_tag="BSU_07270" /old_locus_tag="BSU07270" /EC_number="2.7.7.33" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15634670, 16357223, 26577401" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15634670, 16357223, 26577401; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucose-1-phosphate cytidylyltransferase (sporulation)" /protein_id="NP_388608.1" /db_xref="EnsemblGenomes-Gn:BSU07270" /db_xref="EnsemblGenomes-Tr:CAB12546" /db_xref="GOA:O06486" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR013446" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG12979" /db_xref="UniProtKB/Swiss-Prot:O06486" /translation="MKAVILCGGKGTRMSEVTNDIPKPLAMIGGKPILWHIMKIYQYY GVNEFILLLGYKGEKIKEYFLDYEWKHNSLTLDSSTGEVQMLGQPETWKITFLETGVD TLTAGRILQAKDYIGDETFLLTYGDGLANINLFHLISYHQTKGAAATVTGIDKVSQFG TLTVEDGMAKTFSEKTSSDGIINGGFFVLSPKVFDYLPKDGNTMFEDEPLKNLAKDGE LAVYRHYGFWTAIDTYKNLLEVNKMWNQGQQVWKVW*" /label="spmH CDS" gene 748046..748810 /gene="spmH" /locus_tag="BSU_07270" /old_locus_tag="BSU07270" /label="spmH gene" CDS 748817..749785 /gene="spmG" /locus_tag="BSU_07280" /old_locus_tag="BSU07280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative CDP-sugar-dehydratase/epimerase" /protein_id="NP_388609.2" /db_xref="EnsemblGenomes-Gn:BSU07280" /db_xref="EnsemblGenomes-Tr:CAB12547" /db_xref="GOA:O06485" /db_xref="InterPro:IPR016040" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12978" /db_xref="UniProtKB/Swiss-Prot:O06485" /translation="MSFWKNKNVFVTGCTGLLGSYLVKELIEQGANVTGLVRDHVPQS NLYQGEHIKKMNIVRGSLEDLAVIERALGEYEIDTVFHLAAQAIVGVANRNPISTFEA NILGTWNILEACRKHPLIKRVIVASSDKAYGDQENLPYDENMPLQGKHPYDVSKSCAD LISHTYFHTYGLPVCITRCGNLYGGGDLNFNRIIPQTIQLVLNGEAPEIRSDGTFVRD YFYIEDAVQAYLLLAEKMEENNLAGEAFNFSNEIQLTVLELVEKILKKMNSNLKPKVL NQGSNEIKHQYLSAEKARKLLNWTPAYTIDEGLEKTIEWYTEFFKK*" /label="spmG CDS" gene 748817..749785 /gene="spmG" /locus_tag="BSU_07280" /old_locus_tag="BSU07280" /label="spmG gene" CDS 749809..750720 /gene="yfnF" /locus_tag="BSU_07290" /old_locus_tag="BSU07290" /EC_number="2.4.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_388610.1" /db_xref="EnsemblGenomes-Gn:BSU07290" /db_xref="EnsemblGenomes-Tr:CAB12548" /db_xref="InterPro:IPR005069" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG12977" /db_xref="UniProtKB/Swiss-Prot:O06484" /translation="MTSAYCTVLSKGRLYQAVALFKSLEQVDQDSPIFILCMDEDTHR VLQKLKMKQLNLVPVAALENELLLKLKETRDQSEYCWTMKPIFLQAVLNSNPELERVT YIDGDLFFYADPSPIFENQPDCSVLLSRGDIVIPSFEKEQIDMLQRLLGRYNSGFISF KHDDAGTDCLEWWKERCLEECKNAPGEGKFGDQGYLDYMSELFPNVCDITTPGVNIGH WNYGQHTFSWKDGRIVLEDGSPLIFYHFSGYRIVSINEIKQIHETTRTDLPFVHELYQ ETLPHIIQHMQTLDPEFNGFASKDDNK*" /label="yfnF CDS" gene 749809..750720 /gene="yfnF" /locus_tag="BSU_07290" /old_locus_tag="BSU07290" /label="yfnF gene" promotor_-35 750598..750607 /Source="Nicolas_upshift_promotors" /id="U550" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1259 /SigmaFactorBS="tcagcatcaatgaaatcaaacagattcatgaaacaACCCGCA CAGatctgccgtttgTGCATGAACTGTATCAAGAGacactgccgcatatcattcagca c" /listShort="yfnE, yfnD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 750620..750639 /Source="Nicolas_upshift_promotors" /id="U550" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1259 /SigmaFactorBS="tcagcatcaatgaaatcaaacagattcatgaaacaACCCGCA CAGatctgccgtttgTGCATGAACTGTATCAAGAGacactgccgcatatcattcagca c" /listShort="yfnE, yfnD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 750623 /Source="Nicolas_upshifts" /id="U550" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1259 /SigmaFactorBS="tcagcatcaatgaaatcaaacagattcatgaaacaACCCGCA CAGatctgccgtttgTGCATGAACTGTATCAAGAGacactgccgcatatcattcagca c" /listShort="yfnE, yfnD" /GFF_Attribute="listLong" /label="upshifts" CDS 750749..751927 /gene="yfnE" /locus_tag="BSU_07300" /old_locus_tag="BSU07300" /EC_number="2.4.1.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase (complex carbohydrate synthase)" /protein_id="NP_388611.1" /db_xref="EnsemblGenomes-Gn:BSU07300" /db_xref="EnsemblGenomes-Tr:CAB12549" /db_xref="GOA:O06483" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG12976" /db_xref="UniProtKB/Swiss-Prot:O06483" /translation="MKASVIIPAYNSKERLYNSLLSLNQQECDEEFEVIVADNGSEDG TLSMLESFQADFPLIFTRIKENRGIAYGRNQALRNARGDILIFHDSDMLAAKDLVAKH IKAHENEENLVVCGLFWKRIYSFYYERFEEEHKEQLAKLTGEMPKKDKQKLLEEADIK NGSFLDKSFDLDTDFIDVLKKILDEYGDDLKGYHMPWRFFITNNSSVKRKHVVDLGLF DEGIVRYGFEDYDLGIRLHQAGLTFRLRRDIVSVHQEHPSNCKSVDDIRANIAYMCDK YNNIRSLDVHLAFNGPFPPDMTNRIMADIQKLLESQKYDMLLNLFLELLHVVKERNID PDWRKKSPRVTAKSFDLQTVRKLLPKAKKKLGVNDFANALYALVNDLLHVDLRSLDVV *" /label="yfnE CDS" gene 750749..751927 /gene="yfnE" /locus_tag="BSU_07300" /old_locus_tag="BSU07300" /label="yfnE gene" promotor_-35 751468..751474 /Source="Nicolas_upshift_promotors" /id="U551" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.383616383616384" /psig="0.913086913086913" /xcortree=307 /SigmaFactorBS="tcgggatcaggcttcatcaggccggATTGACCttcaggcttc gccgTGATATTGTCAGTGTTCATCaggaacatccaagcaattgtaagtctgtagacga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 751489..751508 /Source="Nicolas_upshift_promotors" /id="U551" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.383616383616384" /psig="0.913086913086913" /xcortree=307 /SigmaFactorBS="tcgggatcaggcttcatcaggccggATTGACCttcaggcttc gccgTGATATTGTCAGTGTTCATCaggaacatccaagcaattgtaagtctgtagacga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 751503 /Source="Nicolas_upshifts" /id="U551" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.383616383616384" /psig="0.913086913086913" /xcortree=307 /SigmaFactorBS="tcgggatcaggcttcatcaggccggATTGACCttcaggcttc gccgTGATATTGTCAGTGTTCATCaggaacatccaagcaattgtaagtctgtagacga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 751928..752863 /gene="yfnD" /locus_tag="BSU_07310" /old_locus_tag="BSU07310" /EC_number="2.4.1.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase (complex carbohydrate synthase)" /protein_id="NP_388612.1" /db_xref="EnsemblGenomes-Gn:BSU07310" /db_xref="EnsemblGenomes-Tr:CAB12550" /db_xref="InterPro:IPR005069" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG12975" /db_xref="UniProtKB/Swiss-Prot:O31542" /translation="MSTFHFSTIVSRTHIFKLMPMIHSLHEHCDDFHLYVLCVDQKAY ELLQHVPWEHVTFVQLHEMEDPELLKAKSNRTFHEYCWTLKPAFLFHVMSKWDDAEYF AHMDTDLFFFSDPARIFAENPTASLYLTDHRNSPRFMSYYDRTGRFNTGFVGAGNTKE AYEAVWQWRQDCIEFCTVEMDTERKTYGDQRYVEKWPEQFKGVHVVKSIGANTALWNI ENYKVGQKDGRVYIDETPLIFYHFSGFTLVTEKEFNLCWYYRIEDEATIKMIYMPYIL NLKRWIDEIQSAFPDFADGFIPKHAVPDTHFIQLD*" /label="yfnD CDS" gene 751928..752863 /gene="yfnD" /locus_tag="BSU_07310" /old_locus_tag="BSU07310" /label="yfnD gene" downshifts 752735 /Source="Nicolas_upshifts" /id="D359" /incds=1 /nref=1 /ntot=52 /MaxReadThrough="5.41459" /MaxDrop="2.6465" /score="34.8532284" /energy="-15.2" /TU="U549,U550" /idTUdmin="U549" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" downshifts 752845 /Source="Nicolas_upshifts" /id="D360" /incds=0 /nref=2 /ntot=30 /MaxReadThrough="2.32849" /MaxDrop="5.65066" /score="34.8532284" /energy="-15.2" /TU="NA" /idTUdmin="U549" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(752886) /Source="Nicolas_upshifts" /id="D361" /incds=0 /nref=158 /ntot=249 /MaxReadThrough="1.15199" /MaxDrop="4.97014" /score="32.9697757" /energy="-15.2" /TU="NA" /idTUdmin="U552" /TUdmin=13 /isTUend="TRUE" /label="downshifts" CDS complement(752894..754123) /gene="yfnC" /locus_tag="BSU_07320" /old_locus_tag="BSU07320" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388613.1" /db_xref="EnsemblGenomes-Gn:BSU07320" /db_xref="EnsemblGenomes-Tr:CAB12551" /db_xref="GOA:O06481" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12974" /db_xref="UniProtKB/Swiss-Prot:O06481" /translation="MAIAAPLKEKTVQKPGTTVYPILIIIGICHMLNDSLQAVIPAMF PILERSMSLTFTQLGIIAFTLNMVSSVMQPVVGWYTDKRPRPYALPVGLTASMLGILG LAFAPSFITILCCVFFIGLGSAIFHPEGSRVAYMAAGTKRGLAQSIYQVGGNSGQAMA PLITALILVPLGQFGAVWFTLVAALAVMFLMYIAKWYASRLGSLAQKSGKQKKTAENT AITKSVVSALIIIIFLIFARSWYTSAIGNFYTFYAMDTYHVSIQQAQSYIFVFLLFGA IGTFLGGPLADRFGKRFVILGSLLCSAPLAIVLPFAGPVLAYGVLALIGLVLMSSFSV TVVYAQELVPGKIGTMSGLTVGLAFGMGAIGAVALGALIDAAGLTPTMIAIAFLPVLG ILAFLLPSDQKLREWHS*" /label="yfnC CDS" gene complement(752894..754123) /gene="yfnC" /locus_tag="BSU_07320" /old_locus_tag="BSU07320" /label="yfnC gene" promotor_-10 complement(754152..754171) /Source="Nicolas_upshift_promotors" /id="U552" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.909090909090909" /psig="0.997002997002997" /xcortree=2717 /SigmaFactorBS="ggctgacggtatttctttcataagaatcttttttccTCTTGA TAaattcttcaccttatGAATAATATGGTGGTATGCTttggttatatatgtaaggagg a" /listShort="yfnC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(754170) /Source="Nicolas_upshifts" /id="U552" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.909090909090909" /psig="0.997002997002997" /xcortree=2717 /SigmaFactorBS="ggctgacggtatttctttcataagaatcttttttccTCTTGA TAaattcttcaccttatGAATAATATGGTGGTATGCTttggttatatatgtaaggagg a" /listShort="yfnC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(754187..754194) /Source="Nicolas_upshift_promotors" /id="U552" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.909090909090909" /psig="0.997002997002997" /xcortree=2717 /SigmaFactorBS="ggctgacggtatttctttcataagaatcttttttccTCTTGA TAaattcttcaccttatGAATAATATGGTGGTATGCTttggttatatatgtaaggagg a" /listShort="yfnC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(754234..754941) /gene="pynN" /locus_tag="BSU_07330" /old_locus_tag="BSU07330" /EC_number="3.1.3.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyrimidine nucleotide phosphatase (promiscuous)" /protein_id="NP_388614.1" /db_xref="EnsemblGenomes-Gn:BSU07330" /db_xref="EnsemblGenomes-Tr:CAB12552" /db_xref="GOA:O06480" /db_xref="InterPro:IPR006439" /db_xref="InterPro:IPR011951" /db_xref="InterPro:IPR023198" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="PDB:3ED5" /db_xref="PDB:3I76" /db_xref="SubtiList:BG12973" /db_xref="UniProtKB/Swiss-Prot:O06480" /translation="MKRYRTLLFDVDDTILDFQAAEALALRLLFEDQNIPLTNDMKAQ YKTINQGLWRAFEEGKMTRDEVVNTRFSALLKEYGYEADGALLEQKYRRFLEEGHQLI DGAFDLISNLQQQFDLYIVTNGVSHTQYKRLRDSGLFPFFKDIFVSEDTGFQKPMKEY FNYVFERIPQFSAEHTLIIGDSLTADIKGGQLAGLDTCWMNPDMKPNVPEIIPTYEIR KLEELYHILNIENTVSC*" /label="pynN CDS" gene complement(754234..754941) /gene="pynN" /locus_tag="BSU_07330" /old_locus_tag="BSU07330" /label="pynN gene" downshifts complement(754263) /Source="Nicolas_upshifts" /id="D362" /incds=0 /nref=25 /ntot=169 /MaxReadThrough="2.75071" /MaxDrop="4.28644" /score="1.09492978" /energy="-15.7" /TU="NA" /idTUdmin="U553" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(754964..754983) /Source="Nicolas_upshift_promotors" /id="U553" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig="0.998001998001998" /xcortree=3118 /SigmaFactorBS="ttattaaacaaataatctcttttcagccggcggtgcctcacc cgccggctttttcctttttttaTGTGCTATACTTTGAATACAtatgagaaagggagac a" /listShort="yfnB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(754987) /Source="Nicolas_upshifts" /id="U553" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig="0.998001998001998" /xcortree=3118 /SigmaFactorBS="ttattaaacaaataatctcttttcagccggcggtgcctcacc cgccggctttttcctttttttaTGTGCTATACTTTGAATACAtatgagaaagggagac a" /listShort="yfnB" /GFF_Attribute="listLong" /label="upshifts" CDS complement(755033..756418) /gene="mtrA" /locus_tag="BSU_07340" /old_locus_tag="BSU07340" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12022921, 15849754, 16850406, 17114254, 18632116" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12022921, 15849754, 16850406, 17114254, 18632116; Product type t : transporter" /codon_start=1 /transl_table=11 /product="methylthioribose permease" /protein_id="NP_388615.1" /db_xref="EnsemblGenomes-Gn:BSU07340" /db_xref="EnsemblGenomes-Tr:CAB12553" /db_xref="GOA:Q797A7" /db_xref="InterPro:IPR002293" /db_xref="SubtiList:BG12972" /db_xref="UniProtKB/Swiss-Prot:Q797A7" /translation="MSSLFRKKPLETLSAQSKSKSLARTLSAFDLTLLGIGCVIGTGI FVITGTVAATGAGPALIISFILAGLACALAAFCYAEFSSSIPISGSVYSYSYVTLGEL LAFLIGWDLMLEYVIALSAVATGWSSYFQSLLAGFNLHIPAALTGAPGSMAGAVFNLP AAVIILLITAIVSRGVKESTRFNNVIVLMKIAIILLFIIVGIGYVKPDNWSPFMPFGM KGVILSAATVFFAYLGFDAVSNASEEVKNPQKNMPVGIISALAVCTVLYIAVSLVLTG MMPYAKLNVGDPVSFALKFVGQDAVAGIISVGAIIGITTVMLALLYAQVRLTFAMSRD GLLPGLFAKVHPSFKTPFRNTWLTGIVAAGIAGFINLGTLAHLVNMGTLAAFTVISIA VIVLRKKHPEIKASFRVPFVPVVPIISAGICLWFMYSLPGVTWLSFVIWIAVGTLVYF LYSRKHSLLNK*" /label="mtrA CDS" gene complement(755033..756418) /gene="mtrA" /locus_tag="BSU_07340" /old_locus_tag="BSU07340" /label="mtrA gene" downshifts complement(755055) /Source="Nicolas_upshifts" /id="D363" /incds=0 /nref=8 /ntot=91 /MaxReadThrough="3.68565" /MaxDrop="4.73728" /score="31.1617384" /energy="-15.4" /TU="U554" /idTUdmin="U554" /TUdmin="-770" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(756467..756486) /Source="Nicolas_upshift_promotors" /id="U554" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.913086913086913" /psig=1 /xcortree=2397 /SigmaFactorBS="tgtttcgcttctatcatttaaagcagaaaaatatttTATTGA CTacgtcaaatttcgaCAATATAATACAACAAGAACtgcatataatgattagaatatt t" /listShort="yfnA, yfnB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(756484) /Source="Nicolas_upshifts" /id="U554" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.913086913086913" /psig=1 /xcortree=2397 /SigmaFactorBS="tgtttcgcttctatcatttaaagcagaaaaatatttTATTGA CTacgtcaaatttcgaCAATATAATACAACAAGAACtgcatataatgattagaatatt t" /listShort="yfnA, yfnB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(756501..756508) /Source="Nicolas_upshift_promotors" /id="U554" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.913086913086913" /psig=1 /xcortree=2397 /SigmaFactorBS="tgtttcgcttctatcatttaaagcagaaaaatatttTATTGA CTacgtcaaatttcgaCAATATAATACAACAAGAACtgcatataatgattagaatatt t" /listShort="yfnA, yfnB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 756586..756593 /Source="Nicolas_upshift_promotors" /id="U555" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2800 /SigmaFactorBS="aacagcgttgtcgtatcataggatagtaatttttactaatcg tatATTCAATTttatgcaagatgaACCGATAGAAAAAATAGATtcgcccatattttga t" /listShort="yfmT, yfmS" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 756601 /Source="Nicolas_upshifts" /id="U555" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2800 /SigmaFactorBS="aacagcgttgtcgtatcataggatagtaatttttactaatcg tatATTCAATTttatgcaagatgaACCGATAGAAAAAATAGATtcgcccatattttga t" /listShort="yfmT, yfmS" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 756607..756625 /Source="Nicolas_upshift_promotors" /id="U555" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2800 /SigmaFactorBS="aacagcgttgtcgtatcataggatagtaatttttactaatcg tatATTCAATTttatgcaagatgaACCGATAGAAAAAATAGATtcgcccatattttga t" /listShort="yfmT, yfmS" /GFF_Attribute="listLong" /label="promotor_-10" CDS 756668..758125 /gene="vdhT" /locus_tag="BSU_07350" /old_locus_tag="BSU07350" /EC_number="1.2.1.67" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 15033535, 26658822; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="vanillin dehydrogenase" /protein_id="NP_388616.1" /db_xref="EnsemblGenomes-Gn:BSU07350" /db_xref="EnsemblGenomes-Tr:CAB12554" /db_xref="GOA:O06478" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG12971" /db_xref="UniProtKB/Swiss-Prot:O06478" /translation="MFQYEELNKQFIGGKWQEGSSPNVLENKNPYTQKTFTTFRKATA DDVDEAYRAAALAKKKWDAVNPFEKRTILEKAVTYIEENEEAIIYLIMEELGGTRLKA AFEIGLVKNIIKEAATFPIRMEGKILPSTIDGKENRLYRVPAGVVGVISPFNFPFFLS MKSVAPALGAGNGVVLKPHEETPICGGTLIAKIFENAGIPAGLLNVVVTDIAEIGDSF VEHPVPRIISFTGSTKVGSYIGQLAMKHFKKPLLELGGNSAFIVLEDADIEYAVNAAV FSRFTHQGQICMSANRVLVHSSIYDKFLELYQAKVESLKVGDPMDPDTIIGPLINSRQ TDGLMKTVEQAIEEGAVPVKLGGFNGTIVEPTILKDVKPFMSIAKEELFGPVVSFMKF DSEDEAVDIANETPFGLSGAVHTSNLERGVAFAKRIETGMIHVNDTTINDEPNVAFGG EKQSGLGRLNGEWSLEEFTTLKWISVQHEKRSFPY*" /label="vdhT CDS" gene 756668..758125 /gene="vdhT" /locus_tag="BSU_07350" /old_locus_tag="BSU07350" /label="vdhT gene" promotor_-10 complement(757461..757480) /Source="Nicolas_upshift_promotors" /id="U556" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1237 /SigmaFactorBS="ctgacatgcaaatctgcccttgatgtgtaaatcGGCTGAACA CcgccgcattgacCGCATATTCTATATCTGCATcctcaagtacgatgaaggcgctgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(757475) /Source="Nicolas_upshifts" /id="U556" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1237 /SigmaFactorBS="ctgacatgcaaatctgcccttgatgtgtaaatcGGCTGAACA CcgccgcattgacCGCATATTCTATATCTGCATcctcaagtacgatgaaggcgctgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(757493..757502) /Source="Nicolas_upshift_promotors" /id="U556" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1237 /SigmaFactorBS="ctgacatgcaaatctgcccttgatgtgtaaatcGGCTGAACA CcgccgcattgacCGCATATTCTATATCTGCATcctcaagtacgatgaaggcgctgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 758139..758999 /gene="yfmS" /locus_tag="BSU_07360" /old_locus_tag="BSU07360" /function="16.5: Explore" /function="16.3: Control" /function="16.12: Sense" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15033535, 27899502; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="chemotaxis sensory transducer (sensed target unknown)" /protein_id="NP_388617.1" /db_xref="EnsemblGenomes-Gn:BSU07360" /db_xref="EnsemblGenomes-Tr:CAB12555" /db_xref="GOA:O06477" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR029151" /db_xref="SubtiList:BG12970" /db_xref="UniProtKB/Swiss-Prot:O06477" /translation="MELTINTEKETADILDAFIKVAPYLNSLVQDDITIGIYDTEKLL VNIPAKTFSLNVKAGDPLQEGDIITDAIRSNQKKTSMVPKELFGFPLIARAIPLHDEN GRVIGGVGLGTSLEESSKLHDVAESLSAVVEQTAAAISDISESINGFSTQMSGISSQA KKVSESAGEIADISVTVKGISDQSNLLGLNAAIEAARAGESGKGFSVVADEIRKLATH SKENVGQIDQITKKIHSLLKGLEESIESINQHTDGQAAAVEQISATMQEISGSAQHLA KMAEKALEEE*" /label="yfmS CDS" gene 758139..758999 /gene="yfmS" /locus_tag="BSU_07360" /old_locus_tag="BSU07360" /label="yfmS gene" downshifts 758983 /Source="Nicolas_upshifts" /id="D364" /incds=0 /nref=208 /ntot=237 /MaxReadThrough="2.9987" /MaxDrop="6.02377" /score="31.9989755" /energy="-16.7" /TU="U555" /idTUdmin="U555" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" promotor_-35 759067..759074 /Source="Nicolas_upshift_promotors" /id="U557" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.953046953046953" /psig=1 /xcortree=1991 /SigmaFactorBS="tatcctgcatttccatgaaattcgtctgacgtttTACTAGTT ttattccagcggcTGATTTAAAATGTACACATGaacttacgtgaggattgataggaac c" /listShort="yfmR, yfmQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 759088..759107 /Source="Nicolas_upshift_promotors" /id="U557" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.953046953046953" /psig=1 /xcortree=1991 /SigmaFactorBS="tatcctgcatttccatgaaattcgtctgacgtttTACTAGTT ttattccagcggcTGATTTAAAATGTACACATGaacttacgtgaggattgataggaac c" /listShort="yfmR, yfmQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 759093 /Source="Nicolas_upshifts" /id="U557" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.953046953046953" /psig=1 /xcortree=1991 /SigmaFactorBS="tatcctgcatttccatgaaattcgtctgacgtttTACTAGTT ttattccagcggcTGATTTAAAATGTACACATGaacttacgtgaggattgataggaac c" /listShort="yfmR, yfmQ" /GFF_Attribute="listLong" /label="upshifts" CDS 759134..761023 /gene="ettA" /locus_tag="BSU_07370" /old_locus_tag="BSU07370" /EC_number="3.6.3.-" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10715006, 16109936, 18848624, 19948254, 24389465, 24389466; Product type r : regulator" /codon_start=1 /transl_table=11 /product="putative energy-dependent translational throttleA" /protein_id="NP_388618.1" /db_xref="EnsemblGenomes-Gn:BSU07370" /db_xref="EnsemblGenomes-Tr:CAB12556" /db_xref="GOA:O06476" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032524" /db_xref="InterPro:IPR032781" /db_xref="SubtiList:BG12969" /db_xref="UniProtKB/Swiss-Prot:O06476" /translation="MSILKAENLYKTYGDKTLFDHISFHIEENERIGLIGPNGTGKST LLKVIAGLESIEEGEITKSGSVQVEFLHQDPELPAGQTVLEHIYSGESAVMKTLREYE KALYELGKDPENEQRQKHLLAAQAKMDANNAWDANTLAKTVLSKLGVNDVTKPVNELS GGQKKRVAIAKNLIQPADLLILDEPTNHLDNETIEWLEGYLSQYPGAVMLVTHDRYFL NRVTNRIYELERGSLYTYKGNYEVFLEKRAEREAQAEQKETKRQNLLRRELAWLRRGA KARSTKQKARIDRVETLKEQTGPQSSGSLDFAIGSHRLGKQVIEAENVMIAYDGRMLV DRFNELVIPGERIGIIGPNGIGKTTLLNALAGRHTPDGGDITIGQTVRIGYYTQDHSE MNGELKVIDYIKETAEVVKTADGDMITAEQMLERFLFPRSMQQTYIRKLSGGEKRRLY LLQVLMQEPNVLFLDEPTNDLDTETLSVLEDYIDQFPGVVITVSHDRYFLDRVVDRLI VFEGNGVISRFQGSYSDYMEESKAKKAAPKPAAEEKTAEAEPKKKRKKLSYKDQLEWD GIEDKIAQLEEKHEQLEADIAAAGSDFGKIQELMAEQAKTAEELEAAMDRWTELSLMI EELES*" /label="ettA CDS" gene 759134..761023 /gene="ettA" /locus_tag="BSU_07370" /old_locus_tag="BSU07370" /label="ettA gene" downshifts 761007 /Source="Nicolas_upshifts" /id="D365" /incds=0 /nref=2 /ntot=134 /MaxReadThrough="2.98669" /MaxDrop="2.72484" /score="30.3267801" /energy="-13.8" /TU="U557" /idTUdmin="U557" /TUdmin="-572" /isTUend="FALSE" /label="downshifts" misc_feature 761087..761106 /Source="Nicolas_upshift_promotors" /id="U558" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5004995004995" /psig="0.99000999000999" /xcortree=1625 /SigmaFactorBS="gcagcaggccgcgctttttttcacataatggacaaaaacgaa ccggcctgctTATGTTAGGATAAAGTTGTGtgtcagcggcacatggaaaactaacgga g" /listShort="yfmQ" /listLong="yfmP, yfmO" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 761095 /Source="Nicolas_upshifts" /id="U558" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5004995004995" /psig="0.99000999000999" /xcortree=1625 /SigmaFactorBS="gcagcaggccgcgctttttttcacataatggacaaaaacgaa ccggcctgctTATGTTAGGATAAAGTTGTGtgtcagcggcacatggaaaactaacgga g" /listShort="yfmQ" /listLong="yfmP, yfmO" /label="upshifts" CDS 761146..761592 /gene="yfmQ" /locus_tag="BSU_07380" /old_locus_tag="BSU07380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 26483775" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388619.1" /db_xref="EnsemblGenomes-Gn:BSU07380" /db_xref="EnsemblGenomes-Tr:CAB12557" /db_xref="GOA:O06475" /db_xref="InterPro:IPR019723" /db_xref="SubtiList:BG12968" /db_xref="UniProtKB/Swiss-Prot:O06475" /translation="MTWAIVMLILMSLVKIVLTCLPTGVIEWLLGKFEVHAKLSDENA SLSLDGKRLEGAEKQKVIDQFNEAIFLEKYYIYPGDEERYLHPENGGTPLVIDTKKGK KDVKLFVYRYDDHIDVVKQYKKKVIAYRVLSESLQKESLSVAGSLA*" /label="yfmQ CDS" gene 761146..761592 /gene="yfmQ" /locus_tag="BSU_07380" /old_locus_tag="BSU07380" /label="yfmQ gene" downshifts complement(761148) /Source="Nicolas_upshifts" /id="D366" /incds=0 /nref=48 /ntot=154 /MaxReadThrough="1.16717" /MaxDrop="4.57866" /score="0.689181271" /energy="-10.2" /TU="NA" /idTUdmin="U559" /TUdmin=1 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(761232..761235) /Source="Nicolas_upshift_promotors" /id="U559" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.597402597402597" /psig="0.063936063936064" /xcortree=1597 /SigmaFactorBS="tttccatctagagagagactcgcattttcgtcactcagcttg gCGtgcacttcaaatttgccGAGCagccattctatgacgcctgtaggaagacaggtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(761237) /Source="Nicolas_upshifts" /id="U559" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.597402597402597" /psig="0.063936063936064" /xcortree=1597 /SigmaFactorBS="tttccatctagagagagactcgcattttcgtcactcagcttg gCGtgcacttcaaatttgccGAGCagccattctatgacgcctgtaggaagacaggtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(761253..761254) /Source="Nicolas_upshift_promotors" /id="U559" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.597402597402597" /psig="0.063936063936064" /xcortree=1597 /SigmaFactorBS="tttccatctagagagagactcgcattttcgtcactcagcttg gCGtgcacttcaaatttgccGAGCagccattctatgacgcctgtaggaagacaggtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 761579 /Source="Nicolas_upshifts" /id="D367" /incds=0 /nref=254 /ntot=267 /MaxReadThrough="3.12706" /MaxDrop="7.87026" /score="13.6774886" /energy="-8" /TU="U558" /idTUdmin="U557" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 761655..761662 /Source="Nicolas_upshift_promotors" /id="U560" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.606393606393606" /psig="0.999000999001" /xcortree=2124 /SigmaFactorBS="gtcttttttattgttttttaaaacttaACGTTTACgttaagg ttcaaaAGGTGTATAATGGTAACAGAaacggcgaagggggatttaccttggaatggat g" /listShort="yfmP, yfmO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 761676..761695 /Source="Nicolas_upshift_promotors" /id="U560" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.606393606393606" /psig="0.999000999001" /xcortree=2124 /SigmaFactorBS="gtcttttttattgttttttaaaacttaACGTTTACgttaagg ttcaaaAGGTGTATAATGGTAACAGAaacggcgaagggggatttaccttggaatggat g" /listShort="yfmP, yfmO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 761688 /Source="Nicolas_upshifts" /id="U560" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.606393606393606" /psig="0.999000999001" /xcortree=2124 /SigmaFactorBS="gtcttttttattgttttttaaaacttaACGTTTACgttaagg ttcaaaAGGTGTATAATGGTAACAGAaacggcgaagggggatttaccttggaatggat g" /listShort="yfmP, yfmO" /GFF_Attribute="listLong" /label="upshifts" CDS 761717..762139 /gene="copP" /locus_tag="BSU_07390" /old_locus_tag="BSU07390" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14663075" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14663075; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (MerR family) of metal(copper) efflux transporter expression" /protein_id="NP_388620.1" /db_xref="EnsemblGenomes-Gn:BSU07390" /db_xref="EnsemblGenomes-Tr:CAB12558" /db_xref="GOA:O06474" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="SubtiList:BG12967" /db_xref="UniProtKB/Swiss-Prot:O06474" /translation="MEWMKIDQVAKRSGLTKRTIRFYEEIGLIPAPKRTDGGVRLYSE DDMEELEKVISTKEVLGFSLQELQHFMETSRQLELNKEGYLLSLDPKERKEKLEEIQE TLNHQLDLIDEKIRTFQSFKERLQGMKGKAERAIQSIE*" /label="copP CDS" gene 761717..762139 /gene="copP" /locus_tag="BSU_07390" /old_locus_tag="BSU07390" /label="copP gene" downshifts 761975 /Source="Nicolas_upshifts" /id="D368" /incds=1 /nref=2 /ntot=135 /MaxReadThrough="4.24358" /MaxDrop="2.69696" /score="13.6774886" /energy="-8" /TU="U560" /idTUdmin="U558" /TUdmin=308 /isTUend="FALSE" /label="downshifts" CDS 762205..763395 /gene="copO" /locus_tag="BSU_07400" /old_locus_tag="BSU07400" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:14663075, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14663075, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="metal (copper) efflux transporter" /protein_id="NP_388621.1" /db_xref="EnsemblGenomes-Gn:BSU07400" /db_xref="EnsemblGenomes-Tr:CAB12559" /db_xref="GOA:O06473" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12966" /db_xref="UniProtKB/Swiss-Prot:O06473" /translation="MDKTTQVNQKTGLLSQPKAVWAVAFACVISFMGIGLVDPILPAI AAQLHASPSEVSLLFTSYLLVTGFMMFFSGAISSRIGAKWTLILGLIFIIVFAGLGGS SSSIAQLVGYRGGWGLGNALFISTALAVIVGVSVGGSAQAIILYEAALGLGISVGPLA GGELGSISWRAPFFGVSVLMFIALIAISFMLPKLPKPAKRVGVFDAMKALKYKGLLTM AVSAFLYNFGFFILLAYSPFVLDLDEHGLGYVFFGWGLLLAITSVFTAPLVHKALGTV RSLVVLFIAFAAILVIMGIWTDHQTLIITCIVVAGAVLGMVNTIMTTAVMGSAPVERS IASSAYSSVRFIGGALAPWIAGMLSEHFTASTPYTVGGIVVFVGMLVLLMGRKHLAGI KAGH*" /label="copO CDS" gene 762205..763395 /gene="copO" /locus_tag="BSU_07400" /old_locus_tag="BSU07400" /label="copO gene" downshifts complement(763459) /Source="Nicolas_upshifts" /id="D369" /incds=0 /nref=1 /ntot=10 /MaxReadThrough="-0.0437700000000003" /MaxDrop="2.92105" /score="-8.93016606" /energy="-11.6" /TU="NA" /idTUdmin="U562" /TUdmin=528 /isTUend="FALSE" /label="downshifts" CDS 763686..763841 /gene="yfmN" /locus_tag="BSU_07410" /old_locus_tag="BSU07410" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388622.1" /db_xref="EnsemblGenomes-Gn:BSU07410" /db_xref="EnsemblGenomes-Tr:CAB12560" /db_xref="SubtiList:BG12965" /db_xref="UniProtKB/Swiss-Prot:O06472" /translation="MDKAKPDEYDQKCLETLYQYIHSVMKNSFSRSSGLPLGKMRRIL SCLPKES*" /label="yfmN CDS" gene 763686..763841 /gene="yfmN" /locus_tag="BSU_07410" /old_locus_tag="BSU07410" /label="yfmN gene" CDS complement(763961..765517) /gene="ettM" /locus_tag="BSU_07420" /old_locus_tag="BSU07420" /EC_number="3.6.3.-" /function="16.7: Manage energy" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12486040, 16109936, 16684363, 22333191, 24389466; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative energy-sensing inhibitor of translation" /protein_id="NP_388623.2" /db_xref="EnsemblGenomes-Gn:BSU07420" /db_xref="EnsemblGenomes-Tr:CAB12571" /db_xref="GOA:O34512" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032781" /db_xref="SubtiList:BG12964" /db_xref="UniProtKB/Swiss-Prot:O34512" /translation="MSILSVKDLSHGFGDRAIFNNVSFRLLKGEHVGLIGANGEGKST FMNIITGKLEPDEGKVEWSKNVRVGYLDQHTVLEKGKSIRDVLKDAFHYLFAMEEEMN EIYNKMGEADPDELEKLLEEVGVIQDALTNNDFYVIDSKVEEIARGLGLSDIGLERDV TDLSGGQRTKVLLAKLLLEKPEILLLDEPTNYLDEQHIEWLKRYLQEYENAFILISHD IPFLNSVINLIYHVENQELTRYVGDYHQFMEVYEVKKQQLEAAYKKQQQEVAELKDFV ARNKARVSTRNMAMSRQKKLDKMDMIELAAEKPKPEFHFKPARTSGKLIFETKDLVIG YDSPLSRPLNLRMERGQKIALYGANGIGKTTLLKSLLGEIQPLEGSVERGEHIYTGYF EQEVKETNNNTCIEEVWSEFPSYTQYEIRAALAKCGLTTKHIESRVSVLSGGEKAKVR LCKLINSETNLLVLDEPTNHLDADAKEELKRALKEYKGSILLISHEPDFYMDIATETW NCESWTTKVL*" /label="ettM CDS" gene complement(763961..765517) /gene="ettM" /locus_tag="BSU_07420" /old_locus_tag="BSU07420" /label="ettM gene" downshifts complement(763985) /Source="Nicolas_upshifts" /id="D370" /incds=0 /nref=173 /ntot=264 /MaxReadThrough="0.35675" /MaxDrop="5.82627" /score="21.7805812" /energy="-12" /TU="NA" /idTUdmin="U562" /TUdmin=2 /isTUend="TRUE" /label="downshifts" promotor_-35 765347..765353 /Source="Nicolas_upshift_promotors" /id="U561" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=894 /SigmaFactorBS="tttttgaccattcgacttttccCTCATCAggttcaagctttc cGGTAATAATATTcatgaaggttgattttccttcaccgtttgcgccgatcaagccgac g" /listShort="yfmL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 765368..765379 /Source="Nicolas_upshift_promotors" /id="U561" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=894 /SigmaFactorBS="tttttgaccattcgacttttccCTCATCAggttcaagctttc cGGTAATAATATTcatgaaggttgattttccttcaccgtttgcgccgatcaagccgac g" /listShort="yfmL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 765385 /Source="Nicolas_upshifts" /id="U561" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=894 /SigmaFactorBS="tttttgaccattcgacttttccCTCATCAggttcaagctttc cGGTAATAATATTcatgaaggttgattttccttcaccgtttgcgccgatcaagccgac g" /listShort="yfmL" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(765567..765586) /Source="Nicolas_upshift_promotors" /id="U562" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.854145854145854" /psig="0.927072927072927" /xcortree=2609 /SigmaFactorBS="gcaatttttctttttctttcctataCCTTTcaacattccgaa tccTCCTTTATAATCAAAAGGGTgaatattacacgccgattgtgcgtgtttgataacg a" /listShort="yfmM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(765571) /Source="Nicolas_upshifts" /id="U562" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.854145854145854" /psig="0.927072927072927" /xcortree=2609 /SigmaFactorBS="gcaatttttctttttctttcctataCCTTTcaacattccgaa tccTCCTTTATAATCAAAAGGGTgaatattacacgccgattgtgcgtgtttgataacg a" /listShort="yfmM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(765602..765606) /Source="Nicolas_upshift_promotors" /id="U562" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.854145854145854" /psig="0.927072927072927" /xcortree=2609 /SigmaFactorBS="gcaatttttctttttctttcctataCCTTTcaacattccgaa tccTCCTTTATAATCAAAAGGGTgaatattacacgccgattgtgcgtgtttgataacg a" /listShort="yfmM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 765627..765630 /Source="Nicolas_upshift_promotors" /id="U563" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=2547 /SigmaFactorBS="attcggaatgttgaaaggtataggaaagaaaaagaaaaATTG cgttccgggcgaggtTTTGAGATACTATGGAATAGatttcaggaattgaggagaacaa a" /listShort="yfmL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 765646..765665 /Source="Nicolas_upshift_promotors" /id="U563" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=2547 /SigmaFactorBS="attcggaatgttgaaaggtataggaaagaaaaagaaaaATTG cgttccgggcgaggtTTTGAGATACTATGGAATAGatttcaggaattgaggagaacaa a" /listShort="yfmL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 765649 /Source="Nicolas_upshifts" /id="U563" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=2547 /SigmaFactorBS="attcggaatgttgaaaggtataggaaagaaaaagaaaaATTG cgttccgggcgaggtTTTGAGATACTATGGAATAGatttcaggaattgaggagaacaa a" /listShort="yfmL" /GFF_Attribute="listLong" /label="upshifts" CDS 765690..766820 /gene="yfmL" /locus_tag="BSU_07430" /old_locus_tag="BSU07430" /EC_number="3.6.1.-" /function="16.6: Maintain" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11976317; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ATP-dependent RNA helicase" /protein_id="NP_388624.1" /db_xref="EnsemblGenomes-Gn:BSU07430" /db_xref="EnsemblGenomes-Tr:CAB12572" /db_xref="GOA:O34750" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12963" /db_xref="UniProtKB/Swiss-Prot:O34750" /translation="MTQTWPFLHNAQSFIQENWNASGFQKPTPVQEQAAQLIMDGKDV IAESPTGTGKTLAYALPVLERIKPEQKHPQAVILAPSRELVMQIFQVIQDWKAGSELR AASLIGGANVKKQVEKLKKHPHIIVGTPGRVFELIKAKKLKMHEVKTIVLDETDQLVL PEHRETMKQIIKTTLRDRQLLCFSATLKKETEDVLRELAQEPEVLKVQRSKAEAGKVK HQYLICDQRDKVKLLQKLSRLEGMQALVFVRDIGNLSVYAEKLAYHHVELGVLHSEAK KMERAKIIATFEDGEFPLLLATDIAARGLDIENLPYVIHADIPDEDGYVHRSGRTGRA GKEGNVLSLVTKLEESKLKKMAKKLGVELSEAVYAGGKLKTK*" /label="yfmL CDS" gene 765690..766820 /gene="yfmL" /locus_tag="BSU_07430" /old_locus_tag="BSU07430" /label="yfmL gene" downshifts 766803 /Source="Nicolas_upshifts" /id="D371" /incds=0 /nref=43 /ntot=133 /MaxReadThrough="2.93747" /MaxDrop="4.41385" /score="23.4253604" /energy="-5.9" /TU="NA" /idTUdmin="U563" /TUdmin="-12" /isTUend="TRUE" /label="downshifts" CDS 766888..767334 /gene="yfmK" /locus_tag="BSU_07440" /old_locus_tag="BSU07440" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_388625.1" /db_xref="EnsemblGenomes-Gn:BSU07440" /db_xref="EnsemblGenomes-Tr:CAB12573" /db_xref="GOA:O34536" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG12962" /db_xref="UniProtKB/Swiss-Prot:O34536" /translation="MASIDRFQVMQEPELKILEHWFENEDTRRRMDGMLLLDEWYARV NKDKHDTVIMAYDGQLPAGMVVIEFGEERTYIGLIVNPLYRLKGYGKQILQKLMTEPD FTSVREWVACIEEDNRISLACFQAAGFTLEDTEPDEDGFLTLILRN*" /label="yfmK CDS" gene 766888..767334 /gene="yfmK" /locus_tag="BSU_07440" /old_locus_tag="BSU07440" /label="yfmK gene" CDS complement(767387..768406) /gene="yfmJ" /locus_tag="BSU_07450" /old_locus_tag="BSU07450" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388626.1" /db_xref="EnsemblGenomes-Gn:BSU07450" /db_xref="EnsemblGenomes-Tr:CAB12574" /db_xref="GOA:O34812" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12961" /db_xref="UniProtKB/Swiss-Prot:O34812" /translation="MTASQQQIQLARRPQGIPVHEDFRFETIPVPEPKQGEVLVKTLY VSVDPYMRGRMQDTKSYVEPFALDKALSGGVIAEVVSDGNHLKKGDIVIGNLSWQEFS AVSESALRKIDTSLAPASAYLGILGMTGLTAYFGLLDIGRPKEGETVVVSGAAGAVGS TVGQIAKIKGARVVGIAGSDEKIDYLKQELQFDEAINYKTADDIQKALQNACPDGVDV YFDNVGGPISDAVMNLLNEFARIPVCGAISSYNAESEADDMGPRVQSKLIKTKSLMQG FIVSDYSDRFSEGAKQLAEWLKAGKLHYEETITEGFENIPDAFLGLFKGENKGKQLIK VSDPS*" /label="yfmJ CDS" gene complement(767387..768406) /gene="yfmJ" /locus_tag="BSU_07450" /old_locus_tag="BSU07450" /label="yfmJ gene" downshifts complement(767397) /Source="Nicolas_upshifts" /id="D372" /incds=0 /nref=183 /ntot=252 /MaxReadThrough="2.26899" /MaxDrop="5.73395" /score="20.8047206" /energy="-12.8" /TU="NA" /idTUdmin="U564" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(768427..768446) /Source="Nicolas_upshift_promotors" /id="U564" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.654345654345654" /psig=1 /xcortree=3180 /SigmaFactorBS="accttttttgtatgccagcttacctTTTGTATTtcctctcct gtcCATGTTACAGTGGTGTCAACcaagtgataggaggatgaaaatgacagcatctcag c" /listShort="yfmJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(768431) /Source="Nicolas_upshifts" /id="U564" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.654345654345654" /psig=1 /xcortree=3180 /SigmaFactorBS="accttttttgtatgccagcttacctTTTGTATTtcctctcct gtcCATGTTACAGTGGTGTCAACcaagtgataggaggatgaaaatgacagcatctcag c" /listShort="yfmJ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(768433..768887) /Source="Nicolas_S_feature" /locus_tag="new_818856_819310_c" /HighExp="S2, S1, Pyr, T4.0H, T0.0H, T-2.40H, T3.30H, T-1.40H, T-0.40H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S252" promotor_-35 complement(768459..768466) /Source="Nicolas_upshift_promotors" /id="U564" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.654345654345654" /psig=1 /xcortree=3180 /SigmaFactorBS="accttttttgtatgccagcttacctTTTGTATTtcctctcct gtcCATGTTACAGTGGTGTCAACcaagtgataggaggatgaaaatgacagcatctcag c" /listShort="yfmJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 768525..768532 /Source="Nicolas_upshift_promotors" /id="U565" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.993006993006993" /psig="0.999000999001" /xcortree=1939 /SigmaFactorBS="atagatgagcttatgctttctacaagctctttTGTTTTAAaa gttctctttagTCATTTATCATTATTAGAAAacagaacagaaaaagagctcctgtaca c" /listShort="S253" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 768546..768565 /Source="Nicolas_upshift_promotors" /id="U565" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.993006993006993" /psig="0.999000999001" /xcortree=1939 /SigmaFactorBS="atagatgagcttatgctttctacaagctctttTGTTTTAAaa gttctctttagTCATTTATCATTATTAGAAAacagaacagaaaaagagctcctgtaca c" /listShort="S253" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 768553..769650 /Source="Nicolas_S_feature" /locus_tag="new_818976_820073" /HighExp="Etha, dia5, Diami, C30, dia15, T5.0H, S8, T3.0H, M0t90, LPhT" /AntisenseName="yfmI" /AntisenseCor="0.135213889213362" /AntisenseRegPval="-1.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S253" upshifts 768553 /Source="Nicolas_upshifts" /id="U565" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.993006993006993" /psig="0.999000999001" /xcortree=1939 /SigmaFactorBS="atagatgagcttatgctttctacaagctctttTGTTTTAAaa gttctctttagTCATTTATCATTATTAGAAAacagaacagaaaaagagctcctgtaca c" /listShort="S253" /GFF_Attribute="listLong" /label="upshifts" CDS complement(768888..770108) /gene="yfmI" /locus_tag="BSU_07460" /old_locus_tag="BSU07460" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388627.1" /db_xref="EnsemblGenomes-Gn:BSU07460" /db_xref="EnsemblGenomes-Tr:CAB12575" /db_xref="GOA:O34440" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12960" /db_xref="UniProtKB/Swiss-Prot:O34440" /translation="MSKGYYSILFSQTTTNLGFSLYTMVVISFLFKMTNSTTIASMVT LISIIFRIFGSAILPLITIRLKLPLTIIISQLIQMLLLICLFYALLRTYSNQTLILVF IIISCISFFNGWFSPLKSAIIGEIISPDRRVKANGLLSTVDQTFQFVGWSLGGLIIAF LGEGYTIILTIFLLFTSLLSLLFCLPHGHANSVIREKNSPNKSIVSGWRYLFSQKKLR TIIIMDLIESWAGMIWIGSVSLAFVNEVLHKGESWWGFINGAYYLGSMIGGFIIYKLS ERFQNKLINFMLIGAVSYGSLTLIYGFISNSYLALILVLFMGPAYILRDLTQETLIQN ITTEQTRINIMSARSSLVQFIFMFSILAIGAISDFLGVRLVYVSAGILLLVSAIYGFS QLQFKKKVNKHISF*" /label="yfmI CDS" gene complement(768888..770108) /gene="yfmI" /locus_tag="BSU_07460" /old_locus_tag="BSU07460" /label="yfmI gene" promotor_-10 complement(770145..770164) /Source="Nicolas_upshift_promotors" /id="U566" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.899100899100899" /psig="0.996003996003996" /xcortree=2925 /SigmaFactorBS="gtaaatagtttacaaggaaatttttTCTTTACTtttgttgtt ttaaggTGTTTAAATATGTTTAAGCTctttaccgagaaaaattattccaagggaggat a" /listShort="yfmI, S252, yfmJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(770152) /Source="Nicolas_upshifts" /id="U566" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.899100899100899" /psig="0.996003996003996" /xcortree=2925 /SigmaFactorBS="gtaaatagtttacaaggaaatttttTCTTTACTtttgttgtt ttaaggTGTTTAAATATGTTTAAGCTctttaccgagaaaaattattccaagggaggat a" /listShort="yfmI, S252, yfmJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(770180..770187) /Source="Nicolas_upshift_promotors" /id="U566" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.899100899100899" /psig="0.996003996003996" /xcortree=2925 /SigmaFactorBS="gtaaatagtttacaaggaaatttttTCTTTACTtttgttgtt ttaaggTGTTTAAATATGTTTAAGCTctttaccgagaaaaattattccaagggaggat a" /listShort="yfmI, S252, yfmJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 770206..770213 /Source="Nicolas_upshift_promotors" /id="U567" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=480 /SigmaFactorBS="ccttaaaacaacaaaagtaaagaaaaaatttccttgtaaacT ATTTACTtttattctatttatTGTTATTGTTTATTTAAGTTctctgactattctatca a" /listShort="S254, yfmG, S256, S257, S258, S259, yfmA, yflT" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 770225..770400 /Source="Nicolas_S_feature" /locus_tag="new_820648_820823" /HighExp="LoTm, T-1.10H, T-0.40H, S3, M9-stat, T0.0H, T-1.40H, BC, T2.0H, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.98260400000000003" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S254" upshifts 770225 /Source="Nicolas_upshifts" /id="U567" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=480 /SigmaFactorBS="ccttaaaacaacaaaagtaaagaaaaaatttccttgtaaacT ATTTACTtttattctatttatTGTTATTGTTTATTTAAGTTctctgactattctatca a" /listShort="S254, yfmG, S256, S257, S258, S259, yfmA, yflT" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 770228..770247 /Source="Nicolas_upshift_promotors" /id="U567" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=480 /SigmaFactorBS="ccttaaaacaacaaaagtaaagaaaaaatttccttgtaaacT ATTTACTtttattctatttatTGTTATTGTTTATTTAAGTTctctgactattctatca a" /listShort="S254, yfmG, S256, S257, S258, S259, yfmA, yflT" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 770357 /Source="Nicolas_upshifts" /id="D373" /incds=0 /nref=34 /ntot=117 /MaxReadThrough="8.67835" /MaxDrop="8.45742" /score="4.02328636" /energy="-13.7" /TU="U567" /idTUdmin="U565" /TUdmin=748 /isTUend="FALSE" /label="downshifts" CDS 770444..771907 /gene="yfmG" /locus_tag="BSU_07480" /old_locus_tag="BSU07480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_388629.1" /db_xref="EnsemblGenomes-Gn:BSU07480" /db_xref="EnsemblGenomes-Tr:CAB12577" /db_xref="InterPro:IPR005532" /db_xref="InterPro:IPR016187" /db_xref="SubtiList:BG12958" /db_xref="UniProtKB/Swiss-Prot:O34722" /translation="MTLLMQDHKSIYNKDIEILIEVEELITSVPENKKNDFKSLIDNR IMTLLNKIQHPVAAENVFGMCIAYPNTYIRYRLIDFVEKWVPYFSAVETIINLTQDPD DLVSFKAMDVCANHKIEESVAYLSSIIDDVRESISYPKKPVGLGAQKVLSTLLDIFGV EKHEELVMLKNYFDQNGILPNNFDFEEKIPQSLIEEFEKTEEDGMILIPGGFFEFGLN ENEIPDKTFNWKDAVPRQKVWLPPFFIDKYPVTNKDYDIFTEFIEENGHIFCHPNEPQ NKQHRRNTYWDDRYLDNHPVTGIDFYDAFAYARYKGKELPTEFQWEKAARGEKGNVWP WGDKFDPAKVQYAGSLYNEPITSLKSWRENLLKAHADKELNHLTSDIFEQNGESPYGV CGMIGGTWEWTRSELKTKRAFHPIFENVPFNSVNSFAVLKGGSFFSHPGLMFPSFRAK DIPFCRHNEMGIRCVKNIPVYKIRESINGPITNKAIY*" /label="yfmG CDS" gene 770444..771907 /gene="yfmG" /locus_tag="BSU_07480" /old_locus_tag="BSU07480" /label="yfmG gene" S_feature complement(770809..772479) /Source="Nicolas_S_feature" /locus_tag="new_821232_822902_c" /HighExp="H2O2, C30, Salt, Lbstat, dia15, LPhT, dia5, Paraq, HiOs, Diami" /AntisenseName="yfmG" /AntisenseCor="-0.58045119682782798" /AntisenseRegPval="-24.9" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 1" /TUlongSig="SigA" /TUlongPSig="0.996" /label="S255" S_feature 771908..772401 /Source="Nicolas_S_feature" /locus_tag="new_822331_822824" /HighExp="LoTm, T0.0H, T-1.40H, T-0.40H, T-2.40H, T-1.10H, Pyr, T-3.40H, SMMPr, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S256" promotor_-35 772389..772394 /Source="Nicolas_upshift_promotors" /id="U568" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=758 /SigmaFactorBS="aaaagagtatctcgtatagaacataagaagaatgacgagttt tttaAGATTAtcatcaattatgtgaGAATAAAATATTATAAGGGaaaatgaaggctgt c" /listShort="S257" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 772403..775668 /Source="Nicolas_S_feature" /locus_tag="new_822826_826091" /HighExp="LoTm, Pyr, B36, T3.30H, T2.0H, T-0.40H, T2.30H, B60, T4.0H, T3.0H" /AntisenseName="yfmE" /AntisenseCor="-0.61640022790163695" /AntisenseRegPval="-28.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.982, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S257" upshifts 772403 /Source="Nicolas_upshifts" /id="U568" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=758 /SigmaFactorBS="aaaagagtatctcgtatagaacataagaagaatgacgagttt tttaAGATTAtcatcaattatgtgaGAATAAAATATTATAAGGGaaaatgaaggctgt c" /listShort="S257" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 772410..772428 /Source="Nicolas_upshift_promotors" /id="U568" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=758 /SigmaFactorBS="aaaagagtatctcgtatagaacataagaagaatgacgagttt tttaAGATTAtcatcaattatgtgaGAATAAAATATTATAAGGGaaaatgaaggctgt c" /listShort="S257" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(772480..773280) /gene="fecF" /locus_tag="BSU_07490" /old_locus_tag="BSU07490" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16672620, 22194458" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16672620, 22194458; Product type t: transporter" /codon_start=1 /transl_table=11 /product="iron-dicitrate ABC transporter (ATP-binding protein)" /protein_id="NP_388630.1" /db_xref="EnsemblGenomes-Gn:BSU07490" /db_xref="EnsemblGenomes-Tr:CAB12578" /db_xref="GOA:O34510" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12957" /db_xref="UniProtKB/Swiss-Prot:O34510" /translation="MGKLAADQLTLSYDSTVIIDGVDLKIEEGKITALIGANGCGKST ILKSLARLMAPKSGTVLLEGKDIHRQPSKEVAKKLAILPQSPQAPEGLTVEELCYFGR HPHKKLLSKHTQEDHDMVEWALEATGMIELKDRTLDALSGGQRQRAWISMALAQGTDL LLLDEPTTYLDISHQIEVLELLKKLNRDHGRTVVMVLHDLNQAAQYADYLISVLDGKI YNAGTPEDVFTQPFFREVFGLECCIMRSPIDQKPMCLPTGLCPKLRAK*" /label="fecF CDS" gene complement(772480..773280) /gene="fecF" /locus_tag="BSU_07490" /old_locus_tag="BSU07490" /label="fecF gene" CDS complement(773293..774294) /gene="fecE" /locus_tag="BSU_07500" /old_locus_tag="BSU07500" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16672620, 16850406, 22194458" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16672620, 16850406, 22194458; Product type t: transporter" /codon_start=1 /transl_table=11 /product="iron-dicitrate ABC transporter (permease)" /protein_id="NP_388631.1" /db_xref="EnsemblGenomes-Gn:BSU07500" /db_xref="EnsemblGenomes-Tr:CAB12579" /db_xref="GOA:O34832" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12956" /db_xref="UniProtKB/Swiss-Prot:O34832" /translation="MKKTTRKQKRPLLAILILAVILIVLSVISIGIGALYISPDAVVT NLLGLDHSFEFIIQQYRLPRIILAILAGAGLAAAGAILQGVIRNPLASPDVVGISKGS GLAAMAVILIFPESPVYVLPFSAFAGAAIIAVLLLMIARKKSIQPSSLALSGIALGAV CHAGMQYMMVKFPGDVNAALIWLTGSLWGRNWEEVKLLAPWLLILFPIVCILIPKLDL MSLGDELAQGLGENANRLRFILIFTAVALAGSCVAVVGSIGFIGLLAPHIARRLTGEK AKYLLPASALIGAIILLIADTLGRGIMPPVEIPAGILTAVIGAPYFLYLLKFEARKQ* " /label="fecE CDS" gene complement(773293..774294) /gene="fecE" /locus_tag="BSU_07500" /old_locus_tag="BSU07500" /label="fecE gene" promotor_-10 complement(773880..773899) /Source="Nicolas_upshift_promotors" /id="U569" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.954045954045954" /psig="0.998001998001998" /xcortree=2068 /SigmaFactorBS="gagtcgccggtatacgtgcttccgttctccgCATTTGCCgga gccgccattatTGCTGTACTATTATTAATGAtagcccgaaaaaagagcattcagccct c" /listShort="yfmF, S255" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(773892) /Source="Nicolas_upshifts" /id="U569" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.954045954045954" /psig="0.998001998001998" /xcortree=2068 /SigmaFactorBS="gagtcgccggtatacgtgcttccgttctccgCATTTGCCgga gccgccattatTGCTGTACTATTATTAATGAtagcccgaaaaaagagcattcagccct c" /listShort="yfmF, S255" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(773914..773921) /Source="Nicolas_upshift_promotors" /id="U569" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.954045954045954" /psig="0.998001998001998" /xcortree=2068 /SigmaFactorBS="gagtcgccggtatacgtgcttccgttctccgCATTTGCCgga gccgccattatTGCTGTACTATTATTAATGAtagcccgaaaaaagagcattcagccct c" /listShort="yfmF, S255" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(774291..775292) /gene="fecD" /locus_tag="BSU_07510" /old_locus_tag="BSU07510" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16672620, 16850406, 22194458" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16672620, 16850406, 22194458; Product type t : transporter" /codon_start=1 /transl_table=11 /product="iron-dicitrate ABC transporter (permease)" /protein_id="NP_388632.1" /db_xref="EnsemblGenomes-Gn:BSU07510" /db_xref="EnsemblGenomes-Tr:CAB12580" /db_xref="GOA:O34933" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12955" /db_xref="UniProtKB/Swiss-Prot:O34933" /translation="MYHSAKRRSSSRLMMFIIALIIFIFGLGLNLSVGASDISIIDSL KYLFVWDGSKEQLIISTLRLPRTLIGVFVGASLAVAGALMQAMTRNPLASPQIFGVNA GASLFVVASLVILPASPYSSVIFAFAGAAAGGAIVYMIASSGGMTPVKLALSGMAVHL FLSSMTQAIIILNESGEDVLYWMTGAIDGSNWQDVITIAPFSVIGIGLALVFSGSVSV LGLGDETAKGLGQNMNGIRILISLIILILSGASVAVAGPIGFVGLLVPHIVRKLIGEH YQYVLPFSALFGAILLVYADVLARWIAFPYESPVGIVTAIIGTPFFLYLARKGRNLK* " /label="fecD CDS" gene complement(774291..775292) /gene="fecD" /locus_tag="BSU_07510" /old_locus_tag="BSU07510" /label="fecD gene" misc_feature complement(775362..775381) /Source="Nicolas_upshift_promotors" /id="U570" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.664335664335664" /psig="0.701298701298701" /xcortree=1492 /SigmaFactorBS="acacttggacaagattcagaggcatcaagtctagtgaaacaa gcgccaaagatgtgcttaaaAAAGTGTATAATAAATAGGAcaaatgagaagcgagggg a" /listShort="yfmD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(775364..776311) /gene="fecC" /locus_tag="BSU_07520" /old_locus_tag="BSU07520" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16672620, 16850406, 22194458" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16672620, 16850406, 22194458; Product type t : transporter" /codon_start=1 /transl_table=11 /product="iron-dicitrate ABC transporter (binding lipoprotein)" /protein_id="NP_388633.1" /db_xref="EnsemblGenomes-Gn:BSU07520" /db_xref="EnsemblGenomes-Tr:CAB12581" /db_xref="GOA:O34348" /db_xref="InterPro:IPR002491" /db_xref="SubtiList:BG12954" /db_xref="UniProtKB/Swiss-Prot:O34348" /translation="MRTYSNKLIAIMSVLLLACLIVSGCSSSQNNNGSGKSESKDSRV IHDEEGKTTVSGTPKRVVVLELSFLDAVHNLGITPVGIADDNKKDMIKKLVGSSIDYT SVGTRSEPNLEVISSLKPDLIIADAERHKNIYKQLKKIAPTIELKSREATYDETIDSF TTIAKALNKEDEGKEKLAEHKKVINDLKAELPKDENRNIVLGVARADSFQLHTSSSYD GEIFKMLGFTHAVKSDNAYQEVSLEQLSKIDPDILFISANEGKTIVDEWKTNPLWKNL KAVKNGQVYDADRDTWTRFRGIKSSETSAKDVLKKVYNK*" /label="fecC CDS" gene complement(775364..776311) /gene="fecC" /locus_tag="BSU_07520" /old_locus_tag="BSU07520" /label="fecC gene" downshifts complement(775383) /Source="Nicolas_upshifts" /id="D374" /incds=0 /nref=41 /ntot=211 /MaxReadThrough="4.92983" /MaxDrop="4.53674" /score="-3.64310934" /energy="-13.9" /TU="U570,U573,U574" /idTUdmin="U570" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" upshifts complement(775383) /Source="Nicolas_upshifts" /id="U570" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.664335664335664" /psig="0.701298701298701" /xcortree=1492 /SigmaFactorBS="acacttggacaagattcagaggcatcaagtctagtgaaacaa gcgccaaagatgtgcttaaaAAAGTGTATAATAAATAGGAcaaatgagaagcgagggg a" /listShort="yfmD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 775638..775643 /Source="Nicolas_upshift_promotors" /id="U571" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1066 /SigmaFactorBS="atctgacttcacagcgtgtgtaaagcctAGCATTttaaagat ttctccgTCATAGGATGATGATGTATgaagctggaaggaatccgctcttgcaacgccg a" /listShort="S258, S259" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 775659..775677 /Source="Nicolas_upshift_promotors" /id="U571" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1066 /SigmaFactorBS="atctgacttcacagcgtgtgtaaagcctAGCATTttaaagat ttctccgTCATAGGATGATGATGTATgaagctggaaggaatccgctcttgcaacgccg a" /listShort="S258, S259" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 775670..776295 /Source="Nicolas_S_feature" /locus_tag="new_826093_826718" /HighExp="LoTm, B36, S5, S6, S4, S7, S8, S3, BT, B60" /AntisenseName="yfmC" /AntisenseCor="-0.52042999587715499" /AntisenseRegPval="-19.3" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S258" upshifts 775670 /Source="Nicolas_upshifts" /id="U571" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1066 /SigmaFactorBS="atctgacttcacagcgtgtgtaaagcctAGCATTttaaagat ttctccgTCATAGGATGATGATGTATgaagctggaaggaatccgctcttgcaacgccg a" /listShort="S258, S259" /GFF_Attribute="listLong" /label="upshifts" misc_feature 776291..776310 /Source="Nicolas_upshift_promotors" /id="U572" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.905094905094905" /psig="0.997002997002997" /xcortree=1855 /SigmaFactorBS="acagccggatacaatgaggcaggcgagcaataaaacactcat gatggcaatcaaCTTGTTAGAATAGGTGCGCAtgtcattcttccttttttcagattta g" /listShort="S259" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 776297..776828 /Source="Nicolas_S_feature" /locus_tag="new_826720_827251" /HighExp="LoTm, B36, S5, S4, S7, S6, S8, B60, S3, BT" /AntisenseName="yfmB" /AntisenseCor="-6.4915194654100006E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF, SigA" /TUshortPSig="0.997, 0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S259" upshifts 776297 /Source="Nicolas_upshifts" /id="U572" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.905094905094905" /psig="0.997002997002997" /xcortree=1855 /SigmaFactorBS="acagccggatacaatgaggcaggcgagcaataaaacactcat gatggcaatcaaCTTGTTAGAATAGGTGCGCAtgtcattcttccttttttcagattta g" /listShort="S259" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(776353..776372) /Source="Nicolas_upshift_promotors" /id="U573" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.645354645354645" /psig=1 /xcortree=2102 /SigmaFactorBS="aaaacgcagctttctttactaaaaaaaTATTGACAtgataag ccatgcTATTATAGTGTTACATGTGAtaatgattctcattactaaatctgaaaaaagg a" /listShort="yfmC, yfmD, yfmE, yfmF, S255" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(776360) /Source="Nicolas_upshifts" /id="U573" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.645354645354645" /psig=1 /xcortree=2102 /SigmaFactorBS="aaaacgcagctttctttactaaaaaaaTATTGACAtgataag ccatgcTATTATAGTGTTACATGTGAtaatgattctcattactaaatctgaaaaaagg a" /listShort="yfmC, yfmD, yfmE, yfmF, S255" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(776386..776393) /Source="Nicolas_upshift_promotors" /id="U573" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.645354645354645" /psig=1 /xcortree=2102 /SigmaFactorBS="aaaacgcagctttctttactaaaaaaaTATTGACAtgataag ccatgcTATTATAGTGTTACATGTGAtaatgattctcattactaaatctgaaaaaagg a" /listShort="yfmC, yfmD, yfmE, yfmF, S255" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(776420..776788) /gene="yfmB" /locus_tag="BSU_07530" /old_locus_tag="BSU07530" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 25651892" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388634.1" /db_xref="EnsemblGenomes-Gn:BSU07530" /db_xref="EnsemblGenomes-Tr:CAB12582" /db_xref="InterPro:IPR021579" /db_xref="PDB:2EUC" /db_xref="SubtiList:BG12953" /db_xref="UniProtKB/Swiss-Prot:O34626" /translation="MQYFSPEQQYNAWIVSDLVKQIFHKRAGCSPGIHELAVFAEEHF HIDIDFVFSIIMNIGDIEFALTDEIEKKLSGYLSTLLPYVTADMFETSKANAHAFLSR RHGNAAYHLFVSDDAFMRKQ*" /label="yfmB CDS" gene complement(776420..776788) /gene="yfmB" /locus_tag="BSU_07530" /old_locus_tag="BSU07530" /label="yfmB gene" S_feature complement(776789..776901) /Source="Nicolas_S_feature" /locus_tag="new_827212_827324_c" /HighExp="Etha, BC, Sw, M9-stat, T3.30H, T1.30H, T3.0H, T5.0H, T2.30H, T2.0H" /AntisenseName="yfmA" /AntisenseCor="5.8024036419347599E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S260" promotor_-10 complement(776890..776909) /Source="Nicolas_upshift_promotors" /id="U574" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.967032967032967" /psig="0.996003996003996" /xcortree=128 /SigmaFactorBS="gaacattgaagagaaaaacaggaggaatggtagTAGCTATTt gttttccgtcCATGGTAAAGTGATAGGAACgggacctattttcagaaaaatcaaaatt a" /listShort="S260, yfmB, yfmC, yfmD" /listLong="yfmE, yfmF, S255" /label="promotor_-10" upshifts complement(776901) /Source="Nicolas_upshifts" /id="U574" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.967032967032967" /psig="0.996003996003996" /xcortree=128 /SigmaFactorBS="gaacattgaagagaaaaacaggaggaatggtagTAGCTATTt gttttccgtcCATGGTAAAGTGATAGGAACgggacctattttcagaaaaatcaaaatt a" /listShort="S260, yfmB, yfmC, yfmD" /listLong="yfmE, yfmF, S255" /label="upshifts" promotor_-35 complement(776921..776928) /Source="Nicolas_upshift_promotors" /id="U574" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.967032967032967" /psig="0.996003996003996" /xcortree=128 /SigmaFactorBS="gaacattgaagagaaaaacaggaggaatggtagTAGCTATTt gttttccgtcCATGGTAAAGTGATAGGAACgggacctattttcagaaaaatcaaaatt a" /listShort="S260, yfmB, yfmC, yfmD" /listLong="yfmE, yfmF, S255" /label="promotor_-35" promotor_-35 776969..776975 /Source="Nicolas_upshift_promotors" /id="U575" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=221 /SigmaFactorBS="ctaccattcctcctgtttttctcttcaatgttctggaatcTG TTTCAggtacagacgatcGGGTATGAAAGAAATATAGaaaacatgaaggaggaatatc g" /listShort="yflT, S261, pel, yflS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 776989..777007 /Source="Nicolas_upshift_promotors" /id="U575" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=221 /SigmaFactorBS="ctaccattcctcctgtttttctcttcaatgttctggaatcTG TTTCAggtacagacgatcGGGTATGAAAGAAATATAGaaaacatgaaggaggaatatc g" /listShort="yflT, S261, pel, yflS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 776989 /Source="Nicolas_upshifts" /id="U575" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=221 /SigmaFactorBS="ctaccattcctcctgtttttctcttcaatgttctggaatcTG TTTCAggtacagacgatcGGGTATGAAAGAAATATAGaaaacatgaaggaggaatatc g" /listShort="yflT, S261, pel, yflS" /GFF_Attribute="listLong" /label="upshifts" CDS 777032..777379 /gene="yflT" /locus_tag="BSU_07550" /old_locus_tag="BSU07550" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 12089032; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="heat stress induced protein" /protein_id="NP_388636.1" /db_xref="EnsemblGenomes-Gn:BSU07550" /db_xref="EnsemblGenomes-Tr:CAB12584" /db_xref="InterPro:IPR025889" /db_xref="SubtiList:BG19020" /db_xref="UniProtKB/Swiss-Prot:P80241" /translation="MKPVVKEYTNDEQLMKDVEELQKMGVAKEDVYVLAHDDDRTERL ADNTNANTIGAKETGFKHAVGNIFNKKGDELRNKIHEIGFSEDEAAQFEKRLDEGKVL LFVTDNEKVKAWA*" /label="yflT CDS" gene 777032..777379 /gene="yflT" /locus_tag="BSU_07550" /old_locus_tag="BSU07550" /label="yflT gene" downshifts complement(777033) /Source="Nicolas_upshifts" /id="D375" /incds=0 /nref=6 /ntot=28 /MaxReadThrough="1.00082" /MaxDrop="4.87687" /score="-3.31058364" /energy="-3.6" /TU="NA" /idTUdmin="U570" /TUdmin="-1848" /isTUend="FALSE" /label="downshifts" downshifts 777375 /Source="Nicolas_upshifts" /id="D376" /incds=0 /nref=56 /ntot=197 /MaxReadThrough="6.41566" /MaxDrop="7.61596" /score="-1.88723414" /energy="-5.6" /TU="U575" /idTUdmin="U567" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 777420..777500 /Source="Nicolas_S_feature" /locus_tag="new_827843_827923" /HighExp="Etha, Salt, B36, LoTm, Heat, B60, M9-stat, S8, C30, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S261" misc_feature 777501..777520 /Source="Nicolas_upshift_promotors" /id="U576" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.576423576423576" /psig="0.972027972027972" /xcortree=3242 /SigmaFactorBS="gattttgcagaatgccgcaataggatagcggaacattttcgg ttctgaatgtccctcaaTTTGCTATTATATTTTTGTGataaattggaataaaatctca c" /listShort="pel" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 777502 /Source="Nicolas_upshifts" /id="U576" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.576423576423576" /psig="0.972027972027972" /xcortree=3242 /SigmaFactorBS="gattttgcagaatgccgcaataggatagcggaacattttcgg ttctgaatgtccctcaaTTTGCTATTATATTTTTGTGataaattggaataaaatctca c" /listShort="pel" /GFF_Attribute="listLong" /label="upshifts" CDS 777570..778832 /gene="pelA" /locus_tag="BSU_07560" /old_locus_tag="BSU07560" /EC_number="4.2.2.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8262178, 12823818, 27447541" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8262178, 12823818, 27447541; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pectate lyase" /protein_id="NP_388637.1" /db_xref="EnsemblGenomes-Gn:BSU07560" /db_xref="EnsemblGenomes-Tr:CAB12585" /db_xref="GOA:P39116" /db_xref="InterPro:IPR002022" /db_xref="InterPro:IPR011050" /db_xref="InterPro:IPR012334" /db_xref="PDB:1BN8" /db_xref="PDB:2BSP" /db_xref="PDB:2NZM" /db_xref="PDB:2O04" /db_xref="PDB:2O0V" /db_xref="PDB:2O0W" /db_xref="PDB:2O17" /db_xref="PDB:2O1D" /db_xref="PDB:3KRG" /db_xref="PDB:5AMV" /db_xref="SubtiList:BG10840" /db_xref="UniProtKB/Swiss-Prot:P39116" /translation="MKKVMLATALFLGLTPAGANAADLGHQTLGSNDGWGAYSTGTTG GSKASSSNVYTVSNRNQLVSALGKETNTTPKIIYIKGTIDMNVDDNLKPLGLNDYKDP EYDLDKYLKAYDPSTWGKKEPSGTQEEARARSQKNQKARVMVDIPANTTIVGSGTNAK VVGGNFQIKSDNVIIRNIEFQDAYDYFPQWDPTDGSSGNWNSQYDNITINGGTHIWID HCTFNDGSRPDSTSPKYYGRKYQHHDGQTDASNGANYITMSYNYYHDHDKSSIFGSSD SKTSDDGKLKITLHHNRYKNIVQRAPRVRFGQVHVYNNYYEGSTSSSSYPFSYAWGIG KSSKIYAQNNVIDVPGLSAAKTISVFSGGTALYDSGTLLNGTQINASAANGLSSSVGW TPSLHGSIDASANVKSNVINQAGAGKLN*" /label="pelA CDS" gene 777570..778832 /gene="pelA" /locus_tag="BSU_07560" /old_locus_tag="BSU07560" /label="pelA gene" downshifts 778827 /Source="Nicolas_upshifts" /id="D377" /incds=0 /nref=139 /ntot=203 /MaxReadThrough="3.61256" /MaxDrop="5.92635" /score="1.82127533" /energy="-8.2" /TU="U575,U576" /idTUdmin="U576" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" promotor_-35 778885..778888 /Source="Nicolas_upshift_promotors" /id="U577" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.879120879120879" /psig="0.984015984015984" /xcortree=1756 /SigmaFactorBS="gggtgctaacctttgtgttttttaattaattaaaATGTttat taacttagttAAGGAGTAGAATGGAAAAGGggatcggaaaacaagtatataggaggag a" /listShort="yflS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 778903..778922 /Source="Nicolas_upshift_promotors" /id="U577" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.879120879120879" /psig="0.984015984015984" /xcortree=1756 /SigmaFactorBS="gggtgctaacctttgtgttttttaattaattaaaATGTttat taacttagttAAGGAGTAGAATGGAAAAGGggatcggaaaacaagtatataggaggag a" /listShort="yflS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 778911 /Source="Nicolas_upshifts" /id="U577" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.879120879120879" /psig="0.984015984015984" /xcortree=1756 /SigmaFactorBS="gggtgctaacctttgtgttttttaattaattaaaATGTttat taacttagttAAGGAGTAGAATGGAAAAGGggatcggaaaacaagtatataggaggag a" /listShort="yflS" /GFF_Attribute="listLong" /label="upshifts" CDS 778959..780395 /gene="maeS" /locus_tag="BSU_07570" /old_locus_tag="BSU07570" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12949159, 15849754, 16850406, 25651892, 28436820" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12949159, 15849754, 16850406, 25651892, 28436820; Product type t : transporter" /codon_start=1 /transl_table=11 /product="malate (2-oxoglutarate) transporter" /protein_id="NP_388638.1" /db_xref="EnsemblGenomes-Gn:BSU07570" /db_xref="EnsemblGenomes-Tr:CAB12586" /db_xref="GOA:O34726" /db_xref="InterPro:IPR001898" /db_xref="InterPro:IPR030676" /db_xref="SubtiList:BG12951" /db_xref="UniProtKB/Swiss-Prot:O34726" /translation="MASEKDAGKQSAVKLVPLLITVAVGLIIWFIPAPSGLEPKAWHL FAIFVATIIGFISKPLPMGAIAIFALAVTALTGTLSIEDTLSGFGNKTIWLIVIAFFI SRGFIKTGLGARISYVFVQKFGKKTLGLSYSLLFSDLILSPAIPSNTARAGGIIFPII RSLSETFGSSPANGTERKIGAFLLKTGFQGNLITSAMFLTAMAANPLIAKLAHDVAGV DLTWTSWAIAAIVPGLVSLIITPLVIYKLYPPEIKETPDAAKIATEKLKEMGPFKKSE LSMVIVFLLVLVLWIFGGSFNIDATTTALIGLAVLLLSQVLTWDDIKKEQGAWDTLTW FAALVMLANFLNELGMVSWFSNAMKSSVSGFSWIVAFIILIVVYYYSHYFFASATAHI SAMYSAFLAVVVAAGAPPLLAALSLAFISNLFGSTTHYGSGAAPVFFGAGYIPQGKWW SIGFILSIVHIIVWLVIGGLWWKVLGIW*" /label="maeS CDS" gene 778959..780395 /gene="maeS" /locus_tag="BSU_07570" /old_locus_tag="BSU07570" /label="maeS gene" downshifts 780387 /Source="Nicolas_upshifts" /id="D378" /incds=0 /nref=56 /ntot=132 /MaxReadThrough="2.39993" /MaxDrop="5.36125" /score="40.3051497" /energy="-9.7" /TU="NA" /idTUdmin="U577" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" misc_feature 780486..780505 /Source="Nicolas_upshift_promotors" /id="U578" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2939 /SigmaFactorBS="tccttcgtaagaaaatggattttgaaaaatgagaaaattccc tgtgaaaAATGGTATGATCTAGGTAGAaaggacggctggtgctgtggtgaaaaagcgg t" /listShort="citS, citT, yflP" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 780497 /Source="Nicolas_upshifts" /id="U578" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2939 /SigmaFactorBS="tccttcgtaagaaaatggattttgaaaaatgagaaaattccc tgtgaaaAATGGTATGATCTAGGTAGAaaggacggctggtgctgtggtgaaaaagcgg t" /listShort="citS, citT, yflP" /GFF_Attribute="listLong" /label="upshifts" CDS 780522..782150 /gene="citS" /locus_tag="BSU_07580" /old_locus_tag="BSU07580" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:10972810, 11717295, 12949159, 16842348" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10972810, 11717295, 12949159, 16842348; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase" /protein_id="NP_388639.1" /db_xref="EnsemblGenomes-Gn:BSU07580" /db_xref="EnsemblGenomes-Tr:CAB12587" /db_xref="GOA:O34427" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR016120" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12576" /db_xref="UniProtKB/Swiss-Prot:O34427" /translation="MVKKRFHFSLQTKIMGLIAALLVFVIGVLTITLAVQHTQGERRQ AEQLAVQTARTISYMPPVKELIERKDGHAAQTQEVIEQMKEQTGAFAIYVLNEKGDIR SASGKSGLKKLERSREILFGGSHVSETKADGRRVIRGSAPIIKEQKGYSQVIGSVSVD FLQTETEQSIKKHLRNLSVIAVLVLLLGFIGAAVLAKSIRKDTLGLEPHEIAALYRER NAMLFAIREGIIATNREGVVTMMNVSAAEMLKLPEPVIHLPIDDVMPGAGLMSVLEKG EMLPNQEVSVNDQVFIINTKVMNQGGQAYGIVVSFREKTELKKLIDTLTEVRKYSEDL RAQTHEFSNKLYAILGLLELGEYDEAIDLIKEEYAIQNEQHDLLFHNIHSQQVQAILL GKISKASEKKVKLVIDENSSLAPLPAHIGLSHLITIIGNLIDNAFEAVAEQSVKEVLF FITDMGHDIVIEVSDTGPGVPPEKIEAVFERGYSSKGMRRGYGLANVKDSVRELGGWI ELANQKTGGAVFTVFIPKEKQRGNPFDSHRDCGG*" /label="citS CDS" gene 780522..782150 /gene="citS" /locus_tag="BSU_07580" /old_locus_tag="BSU07580" /label="citS gene" CDS 782122..782802 /gene="citT" /locus_tag="BSU_07590" /old_locus_tag="BSU07590" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10972810, 11717295, 12949159, 16842348" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10972810, 11717295, 12949159, 16842348; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator" /protein_id="NP_388640.1" /db_xref="EnsemblGenomes-Gn:BSU07590" /db_xref="EnsemblGenomes-Tr:CAB12588" /db_xref="GOA:O34534" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR024187" /db_xref="InterPro:IPR028141" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12577" /db_xref="UniProtKB/Swiss-Prot:O34534" /translation="MIHIAIAEDDFRVAQIHERLIKQLDGFKIIGKAANAKETLALLK EHKADLLLLDIYMPDELGTALIPDIRSRFPEVDIMIITAATETRHLQEALRAGIAHYL IKPVTADKFRQVLLQYKEKRKLLMSQPEVSQSMIDHIFGNGVKTALPAEDLPTGINSI TLRKIKEALQTASEGLTAEELGEKMGASRTTARRYAEYLVSKEEARAELEYGIIGRPE RKYYLAAD*" /label="citT CDS" gene 782122..782802 /gene="citT" /locus_tag="BSU_07590" /old_locus_tag="BSU07590" /label="citT gene" CDS 782805..783764 /gene="yflP" /locus_tag="BSU_07600" /old_locus_tag="BSU07600" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11029430; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative tricarboxylate transporter component" /protein_id="NP_388641.2" /db_xref="EnsemblGenomes-Gn:BSU07600" /db_xref="EnsemblGenomes-Tr:CAB12589" /db_xref="GOA:O34439" /db_xref="InterPro:IPR005064" /db_xref="SubtiList:BG12950" /db_xref="UniProtKB/Swiss-Prot:O34439" /translation="MKKSIILLNILLIFMQGDIRQAAAPRLPDGPIEIVVPAEPSGGW DVTAQAIQSVLRQKQIVKDDVHIVYKSGGGGEKGWKYVNKSSKQTISMTSSLILSNDL LGQSKLKMSDFTPLAILSKEWQTVALPKGSALTNGKDVLNEINMHPGKVRIGFAPGFG NDDQLSFVRAADMYGIDPFDIQFSQYDSSEQLIQALIRHEIEAASMTLSEAKPYERNG DITLAAVTSDKRLPGFPNVPTWKEQGIPFVFSHWRGILGPKNMSEEEISYWDQALKKV TSSPEWKRKINEQDWESFYLNSRETKRFLEEQSAFYQSIMTGN*" /label="yflP CDS" gene 782805..783764 /gene="yflP" /locus_tag="BSU_07600" /old_locus_tag="BSU07600" /label="yflP gene" downshifts 783733 /Source="Nicolas_upshifts" /id="D379" /incds=0 /nref=76 /ntot=211 /MaxReadThrough="1.1681" /MaxDrop="6.31244" /score="10.4510496" /energy="-6.5" /TU="NA" /idTUdmin="U578" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 783856..783863 /Source="Nicolas_upshift_promotors" /id="U579" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.606393606393606" /psig="0.96003996003996" /xcortree=565 /SigmaFactorBS="aaaaaattaaaaatacaaaaaaaccaaatTATTTACTtgcgg ttggtttTCCCATACGATGGCAAAAAGgcaagacaaaaaggggagtaagggagaaaaa a" /listShort="S262, citM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 783876..783895 /Source="Nicolas_upshift_promotors" /id="U579" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.606393606393606" /psig="0.96003996003996" /xcortree=565 /SigmaFactorBS="aaaaaattaaaaatacaaaaaaaccaaatTATTTACTtgcgg ttggtttTCCCATACGATGGCAAAAAGgcaagacaaaaaggggagtaagggagaaaaa a" /listShort="S262, citM" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 783887..783959 /Source="Nicolas_S_feature" /locus_tag="new_834310_834382" /HighExp="M9-stat, SMMPr, SMM, T0.0H, LoTm, T1.0H, Pyr, T1.30H, Cold, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.96" /TUlongSig="NA" /TUlongPSig="NA" /label="S262" upshifts 783887 /Source="Nicolas_upshifts" /id="U579" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.606393606393606" /psig="0.96003996003996" /xcortree=565 /SigmaFactorBS="aaaaaattaaaaatacaaaaaaaccaaatTATTTACTtgcgg ttggtttTCCCATACGATGGCAAAAAGgcaagacaaaaaggggagtaagggagaaaaa a" /listShort="S262, citM" /GFF_Attribute="listLong" /label="upshifts" CDS 783960..785261 /gene="citM" /locus_tag="BSU_07610" /old_locus_tag="BSU07610" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12427932, 12533460, 12906362, 12949159, 15849754, 16842348, 16850406, 24415722, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12427932, 12533460, 12906362, 12949159, 15849754, 16842348, 16850406, 24415722, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="transporter of divalent metal ions/citrate complexes" /protein_id="NP_388642.1" /db_xref="EnsemblGenomes-Gn:BSU07610" /db_xref="EnsemblGenomes-Tr:CAB12590" /db_xref="GOA:P55069" /db_xref="InterPro:IPR004680" /db_xref="InterPro:IPR014738" /db_xref="SubtiList:BG11832" /db_xref="UniProtKB/Swiss-Prot:P55069" /translation="MLAILGFLMMLVFMALIMTKRLSVLTALVLTPIVFALIAGFGFT EVGDMMISGIQQVAPTAVMIMFAILYFGIMIDTGLFDPMVGKILSMVKGDPLKIVVGT AVLTMLVALDGDGSTTYMITTSAMLPLYLLLGIRPIILAGIAGVGMGIMNTIPWGGAT PRAASALGVDPAELTGPMIPVIASGMLCMVAVAYVLGKAERKRLGVIELKQPANANEP AAAVEDEWKRPKLWWFNLLLTLSLIGCLVSGKVSLTVLFVIAFCIALIVNYPNLEHQR QRIAAHSSNVLAIGSMIFAAGVFTGILTGTKMVDEMAISLVSMIPEQMGGLIPAIVAL TSGIFTFLMPNDAYFYGVLPILSETAVAYGVDKVEIARASIIGQPIHMLSPLVPSTHL LVGLVGVSIDDHQKFALKWAVLAVIVMTAIALLIGAISISV*" /label="citM CDS" gene 783960..785261 /gene="citM" /locus_tag="BSU_07610" /old_locus_tag="BSU07610" /label="citM gene" promotor_-35 785258..785264 /Source="Nicolas_upshift_promotors" /id="U580" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=920 /SigmaFactorBS="ggctatcgctctattgatcggtgcgatctctatttccgtATG ATAAttcaggcgtaatgACACACACTAACggcatacaacattccggaggtgtcattat g" /listShort="yflN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 785278..785289 /Source="Nicolas_upshift_promotors" /id="U580" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=920 /SigmaFactorBS="ggctatcgctctattgatcggtgcgatctctatttccgtATG ATAAttcaggcgtaatgACACACACTAACggcatacaacattccggaggtgtcattat g" /listShort="yflN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 785279 /Source="Nicolas_upshifts" /id="U580" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=920 /SigmaFactorBS="ggctatcgctctattgatcggtgcgatctctatttccgtATG ATAAttcaggcgtaatgACACACACTAACggcatacaacattccggaggtgtcattat g" /listShort="yflN" /GFF_Attribute="listLong" /label="upshifts" CDS 785317..786111 /gene="yflN" /locus_tag="BSU_07620" /old_locus_tag="BSU07620" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10972810, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent hydrolase" /protein_id="NP_388643.1" /db_xref="EnsemblGenomes-Gn:BSU07620" /db_xref="EnsemblGenomes-Tr:CAB12591" /db_xref="GOA:O34409" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG12949" /db_xref="UniProtKB/Swiss-Prot:O34409" /translation="MSDPYMPLTSVRSGAGFEAAKGVHGLTVQIANVYFIQLPSEPHS FVLIDAGMPQSAGVIVNEAKQRFGEGFQLKAIILTHGHFDHIGAIEEILEHWDVPVYI HSREMPYVTGKEDYPPARPDSKSGLVAKLSPLFPRHSIDISSHVQALPEDGSVPFLDE WMWIATPGHTPGHISLFRDDGRVLVAGDAVITVEQEKMADVLIQKQELHGPPAYFTPD TETAAESILKLAGLEPEALLTGHGIPMTGKNFRSDLTELANRLSSI*" /label="yflN CDS" gene 785317..786111 /gene="yflN" /locus_tag="BSU_07620" /old_locus_tag="BSU07620" /label="yflN gene" downshifts 786087 /Source="Nicolas_upshifts" /id="D380" /incds=0 /nref=2 /ntot=25 /MaxReadThrough="0.0114999999999998" /MaxDrop="3.05232" /score="38.3109333" /energy="-11.8" /TU="NA" /idTUdmin="U580" /TUdmin=132 /isTUend="FALSE" /label="downshifts" promotor_-35 786166..786169 /Source="Nicolas_upshift_promotors" /id="U581" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.509490509490509" /psig="0.995004995004995" /xcortree=2378 /SigmaFactorBS="attgttttccaggaagttgcagaaaaatcATTTgtcttgccg cttaaAAACGATACAATGAAAAGCAtgaagtgatgtgaaggggagagtttgttggaag a" /listShort="nosA, S263, yflK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 786184..786203 /Source="Nicolas_upshift_promotors" /id="U581" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.509490509490509" /psig="0.995004995004995" /xcortree=2378 /SigmaFactorBS="attgttttccaggaagttgcagaaaaatcATTTgtcttgccg cttaaAAACGATACAATGAAAAGCAtgaagtgatgtgaaggggagagtttgttggaag a" /listShort="nosA, S263, yflK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 786197 /Source="Nicolas_upshifts" /id="U581" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.509490509490509" /psig="0.995004995004995" /xcortree=2378 /SigmaFactorBS="attgttttccaggaagttgcagaaaaatcATTTgtcttgccg cttaaAAACGATACAATGAAAAGCAtgaagtgatgtgaaggggagagtttgttggaag a" /listShort="nosA, S263, yflK" /GFF_Attribute="listLong" /label="upshifts" CDS 786230..787321 /gene="nosA" /locus_tag="BSU_07630" /old_locus_tag="BSU07630" /EC_number="1.14.13.39" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11856757, 12220171, 16172391, 25643072, 25826316, 26062720" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11856757, 12220171, 16172391, 25643072, 25826316, 26062720; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="nitric-oxide synthase" /protein_id="NP_388644.2" /db_xref="EnsemblGenomes-Gn:BSU07630" /db_xref="EnsemblGenomes-Tr:CAB12592" /db_xref="GOA:O34453" /db_xref="InterPro:IPR004030" /db_xref="InterPro:IPR017142" /db_xref="InterPro:IPR036119" /db_xref="PDB:1M7V" /db_xref="PDB:1M7Z" /db_xref="PDB:2AMO" /db_xref="PDB:2AN0" /db_xref="PDB:2AN2" /db_xref="PDB:2FBZ" /db_xref="PDB:2FC1" /db_xref="PDB:2FC2" /db_xref="PDB:4D3I" /db_xref="PDB:4D3J" /db_xref="PDB:4D3K" /db_xref="PDB:4D3M" /db_xref="PDB:4D3N" /db_xref="PDB:4D3O" /db_xref="PDB:4D3T" /db_xref="PDB:4D3U" /db_xref="PDB:4D3V" /db_xref="PDB:4D7H" /db_xref="PDB:4D7I" /db_xref="PDB:4D7J" /db_xref="PDB:4LWA" /db_xref="PDB:4LWB" /db_xref="PDB:4UG5" /db_xref="PDB:4UG6" /db_xref="PDB:4UG7" /db_xref="PDB:4UG8" /db_xref="PDB:4UG9" /db_xref="PDB:4UGA" /db_xref="PDB:4UGB" /db_xref="PDB:4UGC" /db_xref="PDB:4UGD" /db_xref="PDB:4UGE" /db_xref="PDB:4UGF" /db_xref="PDB:4UGG" /db_xref="PDB:4UGH" /db_xref="PDB:4UGI" /db_xref="PDB:4UGJ" /db_xref="PDB:4UGK" /db_xref="PDB:4UGL" /db_xref="PDB:4UGM" /db_xref="PDB:4UGN" /db_xref="PDB:4UGO" /db_xref="PDB:4UGP" /db_xref="PDB:4UGQ" /db_xref="PDB:4UGR" /db_xref="PDB:4UGS" /db_xref="PDB:4UGT" /db_xref="PDB:4UGU" /db_xref="PDB:4UGV" /db_xref="PDB:4UGW" /db_xref="PDB:4UGX" /db_xref="PDB:4UGY" /db_xref="PDB:4UQR" /db_xref="PDB:4UQS" /db_xref="PDB:5G65" /db_xref="PDB:5G66" /db_xref="PDB:5G67" /db_xref="PDB:5G68" /db_xref="PDB:5G69" /db_xref="PDB:5G6A" /db_xref="PDB:5G6B" /db_xref="PDB:5G6C" /db_xref="PDB:5G6D" /db_xref="PDB:5G6E" /db_xref="PDB:5G6F" /db_xref="PDB:5G6G" /db_xref="PDB:5G6H" /db_xref="PDB:5G6I" /db_xref="PDB:5G6J" /db_xref="PDB:5G6K" /db_xref="PDB:5G6L" /db_xref="PDB:5G6M" /db_xref="PDB:5G6N" /db_xref="PDB:5G6O" /db_xref="PDB:5G6P" /db_xref="PDB:5G6Q" /db_xref="SubtiList:BG12948" /db_xref="UniProtKB/Swiss-Prot:O34453" /translation="MEEKEILWNEAKAFIAACYQELGKEEEVKDRLADIKSEIDLTGS YVHTKEELEHGAKMAWRNSNRCIGRLFWNSLNVIDRRDVRTKEEVRDALFHHIETATN NGKIRPTITIFPPEEKGEKQVEIWNHQLIRYAGYESDGERIGDPASCSLTAACEELGW RGERTDFDLLPLIFRMKGDEQPVWYELPRSLVIEVPITHPDIEAFSDLELKWYGVPII SDMKLEVGGIHYNAAPFNGWYMGTEIGARNLADEKRYDKLKKVASVIGIAADYNTDLW KDQALVELNKAVLHSYKKQGVSIVDHHTAASQFKRFEEQEEEAGRKLTGDWTWLIPPI SPAATHIFHRSYDNSIVKPNYFYQDKPYE*" /label="nosA CDS" gene 786230..787321 /gene="nosA" /locus_tag="BSU_07630" /old_locus_tag="BSU07630" /label="nosA gene" CDS complement(787312..787587) /gene="acyP" /locus_tag="BSU_07640" /old_locus_tag="BSU07640" /EC_number="3.6.1.7" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:20447399" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20447399; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acylphosphatase" /protein_id="NP_388645.1" /db_xref="EnsemblGenomes-Gn:BSU07640" /db_xref="EnsemblGenomes-Tr:CAB12593" /db_xref="GOA:O35031" /db_xref="InterPro:IPR001792" /db_xref="InterPro:IPR017968" /db_xref="InterPro:IPR020456" /db_xref="InterPro:IPR036046" /db_xref="PDB:2FHM" /db_xref="PDB:2HLT" /db_xref="PDB:2HLU" /db_xref="PDB:3BR8" /db_xref="SubtiList:BG12947" /db_xref="UniProtKB/Swiss-Prot:O35031" /translation="MLQYRIIVDGRVQGVGFRYFVQMEADKRKLAGWVKNRDDGRVEI LAEGPENALQSFVEAVKNGSPFSKVTDISVTESRSLEGHHRFSIVYS*" /label="acyP CDS" gene complement(787312..787587) /gene="acyP" /locus_tag="BSU_07640" /old_locus_tag="BSU07640" /label="acyP gene" S_feature 787322..787653 /Source="Nicolas_S_feature" /locus_tag="new_837745_838076" /HighExp="C90, BI, Paraq, LBGexp, Oxctl, M0t45, G150, M40t45, G135, H2O2" /AntisenseName="yflL" /AntisenseCor="0.38657275217332299" /AntisenseRegPval="-10.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S263" promotor_-10 complement(787601..787620) /Source="Nicolas_upshift_promotors" /id="U582" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.818181818181818" /psig="0.998001998001998" /xcortree=3152 /SigmaFactorBS="ctgaatagcgctcttgtttcatacaaacacatcCCCTTTACa ggttgtaaaatgaTTGATTATCATAAAAAGAAAaggtggtttttacatgcttcaatac c" /listShort="yflL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(787615) /Source="Nicolas_upshifts" /id="U582" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.818181818181818" /psig="0.998001998001998" /xcortree=3152 /SigmaFactorBS="ctgaatagcgctcttgtttcatacaaacacatcCCCTTTACa ggttgtaaaatgaTTGATTATCATAAAAAGAAAaggtggtttttacatgcttcaatac c" /listShort="yflL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(787635..787642) /Source="Nicolas_upshift_promotors" /id="U582" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.818181818181818" /psig="0.998001998001998" /xcortree=3152 /SigmaFactorBS="ctgaatagcgctcttgtttcatacaaacacatcCCCTTTACa ggttgtaaaatgaTTGATTATCATAAAAAGAAAaggtggtttttacatgcttcaatac c" /listShort="yflL" /GFF_Attribute="listLong" /label="promotor_-35" CDS 787654..788319 /gene="yflK" /locus_tag="BSU_07650" /old_locus_tag="BSU07650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11886751; Product type c: carrier" /codon_start=1 /transl_table=11 /product="putative sulfur carrier" /protein_id="NP_388646.1" /db_xref="EnsemblGenomes-Gn:BSU07650" /db_xref="EnsemblGenomes-Tr:CAB12594" /db_xref="GOA:O34542" /db_xref="InterPro:IPR005163" /db_xref="InterPro:IPR005302" /db_xref="InterPro:IPR011037" /db_xref="SubtiList:BG12946" /db_xref="UniProtKB/Swiss-Prot:O34542" /translation="MKQERYSVLSLNLGKPQTLEYDGKKIETGIMKRPAKSAVMLYRE NFEGDGQADLVNHGGPDKAVCVYPAEHYPFWEEFLSRPLSNAAFGENLTVAGLTEENV CIGDVFRLDEAVVQVSQPRQPCVKLAKKFGVKEMVLKVQQTGYTGFYFRVLEEGRVSP GANLELLSRGEKGISVQFANRINYHDAKNLTAIERILSEAALSESWRASFMKKKDRLL PVE*" /label="yflK CDS" gene 787654..788319 /gene="yflK" /locus_tag="BSU_07650" /old_locus_tag="BSU07650" /label="yflK gene" CDS complement(788360..788497) /gene="yflJ" /locus_tag="BSU_07660" /old_locus_tag="BSU07660" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388647.1" /db_xref="EnsemblGenomes-Gn:BSU07660" /db_xref="EnsemblGenomes-Tr:CAB12595" /db_xref="InterPro:IPR022580" /db_xref="SubtiList:BG12945" /db_xref="UniProtKB/Swiss-Prot:O34345" /translation="MHYGSKGWYVAELKKQGITHHEGRKLQSYKTYFLANLLESKKKQ S*" /label="yflJ CDS" gene complement(788360..788497) /gene="yflJ" /locus_tag="BSU_07660" /old_locus_tag="BSU07660" /label="yflJ gene" downshifts complement(788374) /Source="Nicolas_upshifts" /id="D381" /incds=0 /nref=136 /ntot=260 /MaxReadThrough="0.0927600000000002" /MaxDrop="8.10929" /score="29.8336543" /energy="-14.8" /TU="NA" /idTUdmin="U583" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" S_feature complement(788498..788628) /Source="Nicolas_S_feature" /locus_tag="new_838921_839051_c" /HighExp="S4, S7, S8, S6, S5, S3, B36, BT, LoTm, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.967, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S264" promotor_-10 complement(788614..788632) /Source="Nicolas_upshift_promotors" /id="U583" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=1134 /SigmaFactorBS="ttggcgttgtcatgatcaaactaaccggccattaaATCATAt tcggcttttgctccGCATATACATTCAGAAGAAcattcgtacatctagtgcgaaaggc t" /listShort="S264, yflJ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 788624..788629 /Source="Nicolas_upshift_promotors" /id="U584" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1109 /SigmaFactorBS="gaaaactgagcctttcgcactagatgtacgaatgttcttctg aaTGTATAtgcggagcaaaagccGAATATGATTTAATGGCCGgttagtttgatcatga c" /listShort="S265" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(788628) /Source="Nicolas_upshifts" /id="U583" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=1134 /SigmaFactorBS="ttggcgttgtcatgatcaaactaaccggccattaaATCATAt tcggcttttgctccGCATATACATTCAGAAGAAcattcgtacatctagtgcgaaaggc t" /listShort="S264, yflJ" /GFF_Attribute="listLong" /label="upshifts" S_feature 788639..789703 /Source="Nicolas_S_feature" /locus_tag="new_839062_840126" /HighExp="S8, S6, S5, S7, S4, S3, BT, B36, C90, T5.0H" /AntisenseName="mapB" /AntisenseCor="-0.26446079057314398" /AntisenseRegPval="-5" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S265" upshifts 788640 /Source="Nicolas_upshifts" /id="U584" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1109 /SigmaFactorBS="gaaaactgagcctttcgcactagatgtacgaatgttcttctg aaTGTATAtgcggagcaaaagccGAATATGATTTAATGGCCGgttagtttgatcatga c" /listShort="S265" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 788645..788663 /Source="Nicolas_upshift_promotors" /id="U584" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1109 /SigmaFactorBS="gaaaactgagcctttcgcactagatgtacgaatgttcttctg aaTGTATAtgcggagcaaaagccGAATATGATTTAATGGCCGgttagtttgatcatga c" /listShort="S265" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(788648..788653) /Source="Nicolas_upshift_promotors" /id="U583" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=1134 /SigmaFactorBS="ttggcgttgtcatgatcaaactaaccggccattaaATCATAt tcggcttttgctccGCATATACATTCAGAAGAAcattcgtacatctagtgcgaaaggc t" /listShort="S264, yflJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(788654..788809) /gene="yflI" /locus_tag="BSU_07670" /old_locus_tag="BSU07670" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved membrane protein" /protein_id="NP_388648.1" /db_xref="EnsemblGenomes-Gn:BSU07670" /db_xref="EnsemblGenomes-Tr:CAB12596" /db_xref="GOA:O34905" /db_xref="SubtiList:BG12944" /db_xref="UniProtKB/Swiss-Prot:O34905" /translation="MWFIIFGIIFFIEGIIMTVYGVKKKNGMLTYIGIVFAIMTFGVV MIKLTGH*" /label="yflI CDS" gene complement(788654..788809) /gene="yflI" /locus_tag="BSU_07670" /old_locus_tag="BSU07670" /label="yflI gene" S_feature complement(788810..788915) /Source="Nicolas_S_feature" /locus_tag="new_839233_839338_c" /HighExp="Etha, Salt, Diami, dia15, H2O2, Cold, G135, Paraq, LPhT, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S266" CDS complement(788916..789230) /gene="yflH" /locus_tag="BSU_07680" /old_locus_tag="BSU07680" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 1070366, 1266368; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_388649.1" /db_xref="EnsemblGenomes-Gn:BSU07680" /db_xref="EnsemblGenomes-Tr:CAB12597" /db_xref="InterPro:IPR021637" /db_xref="PDB:3D0W" /db_xref="SubtiList:BG12943" /db_xref="UniProtKB/Swiss-Prot:O34306" /translation="MNRDQEKIQIENEMNAMHGTIKEDILKDFEEFKGYLKKQVNRGK KLGLDDGKLVKSAAILGDYLAKHEEPQNGEEMLLQELWSVADEDEKEHLAQLLVKLVD KQ*" /label="yflH CDS" gene complement(788916..789230) /gene="yflH" /locus_tag="BSU_07680" /old_locus_tag="BSU07680" /label="yflH gene" S_feature complement(789231..789311) /Source="Nicolas_S_feature" /locus_tag="new_839654_839734_c" /HighExp="dia5, dia15, Diami, LBGtran, LPhT, H2O2, Etha, Lbtran, M40t45, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S267" CDS complement(789312..790061) /gene="mapB" /locus_tag="BSU_07690" /old_locus_tag="BSU07690" /EC_number="3.4.11.18" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16207374" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16207374; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methionine aminopeptidase B" /protein_id="NP_388650.1" /db_xref="EnsemblGenomes-Gn:BSU07690" /db_xref="EnsemblGenomes-Tr:CAB12598" /db_xref="GOA:O34484" /db_xref="InterPro:IPR000994" /db_xref="InterPro:IPR001714" /db_xref="InterPro:IPR002467" /db_xref="InterPro:IPR036005" /db_xref="SubtiList:BG12942" /db_xref="UniProtKB/Swiss-Prot:O34484" /translation="MIVTNDQELEGLKKIGRIVALAREEMKRKAEPGMSTKDLDLIGK AVLDEHGAVSAPEKEYDFPGVTCISVNDEVAHGIPSTSKILKAGDLVNIDISAEFGGF YSDTGISFVLGEGEERLHKLCQCAENAFQKGLQQAKAGKRQNQIGRAVYHEARSQGFT VIKTLTGHGIGRSLHEAPNHIMNYYDPFDNALFKNGTVIALEPFISTKAETIVEAGDG WTFKTPDKSMVAQVEHTIVITKDEPIILTKL*" /label="mapB CDS" gene complement(789312..790061) /gene="mapB" /locus_tag="BSU_07690" /old_locus_tag="BSU07690" /label="mapB gene" promotor_-10 complement(790090..790109) /Source="Nicolas_upshift_promotors" /id="U585" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=1950 /SigmaFactorBS="cccgggggtatttcttttttcccaggtccgtgtgTTTCCTAT TtttaagacagtTGTGGTAAGCTTAATCTAGAttatttaaaaagaaagcgggaatgac a" /listShort="mapB, S267, yflH, S266, yflI, S264, yflJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(790103) /Source="Nicolas_upshifts" /id="U585" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=1950 /SigmaFactorBS="cccgggggtatttcttttttcccaggtccgtgtgTTTCCTAT TtttaagacagtTGTGGTAAGCTTAATCTAGAttatttaaaaagaaagcgggaatgac a" /listShort="mapB, S267, yflH, S266, yflI, S264, yflJ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(790105..791241) /Source="Nicolas_S_feature" /locus_tag="new_840528_841664_c" /HighExp="S6, S8, S7, S5, BT, C30, Paraq, B36, G180, Pyr" /AntisenseName="nagP" /AntisenseCor="0.180776000778922" /AntisenseRegPval="-2.5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S268" promotor_-35 complement(790121..790129) /Source="Nicolas_upshift_promotors" /id="U585" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=1950 /SigmaFactorBS="cccgggggtatttcttttttcccaggtccgtgtgTTTCCTAT TtttaagacagtTGTGGTAAGCTTAATCTAGAttatttaaaaagaaagcgggaatgac a" /listShort="mapB, S267, yflH, S266, yflI, S264, yflJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 790172..790173 /Source="Nicolas_upshift_promotors" /id="U586" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.493506493506494" /psig="0.995004995004995" /xcortree=1559 /SigmaFactorBS="gacctgggaaaaaagaaatacccccgggaaaattggTAtaga tcactagatatcttaTATGGTATATTTGAAAAAAAagggtatgagggggatgggtatg c" /listShort="nagP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 790193..790212 /Source="Nicolas_upshift_promotors" /id="U586" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.493506493506494" /psig="0.995004995004995" /xcortree=1559 /SigmaFactorBS="gacctgggaaaaaagaaatacccccgggaaaattggTAtaga tcactagatatcttaTATGGTATATTTGAAAAAAAagggtatgagggggatgggtatg c" /listShort="nagP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 790196 /Source="Nicolas_upshifts" /id="U586" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.493506493506494" /psig="0.995004995004995" /xcortree=1559 /SigmaFactorBS="gacctgggaaaaaagaaatacccccgggaaaattggTAtaga tcactagatatcttaTATGGTATATTTGAAAAAAAagggtatgagggggatgggtatg c" /listShort="nagP" /GFF_Attribute="listLong" /label="upshifts" CDS 790233..791591 /gene="nagP" /locus_tag="BSU_07700" /old_locus_tag="BSU07700" /function="16.11: Scavenge (Catabolism)" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15849754, 16850406, 8246840; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) N-acetylglucosamine-specific enzyme IICB component" /protein_id="NP_388651.1" /db_xref="EnsemblGenomes-Gn:BSU07700" /db_xref="EnsemblGenomes-Tr:CAB12599" /db_xref="GOA:O34521" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR010974" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG12941" /db_xref="UniProtKB/Swiss-Prot:O34521" /translation="MLSFLQKLGKSFMLPIAVLPAVGIILALGREDVFNIPFVYQAGT AVFDHLPLIFAIGIAIGISKDSNGAAGLSGAISYLMLDAATKTIDKTNNMAVFGGIIA GLIAGYTYNRFKDTKLPEYLGFFSGRRLVPILTAIITIILAGIFGVVWPPIQSCINSF GEWMLGLGGIGAGIFGLFNRLLIPLGLHHVLNNIFWFQFGEYNGVTGDLARFFAKDPT AGTYMTGFFPIMMFGLPAACLAMVVTAKPSKRKATAGMMIGFALTAFITGITEPIEFA FMFLSPLLYAVHAVLTGLSLFIVNWLGIRSGFSFSAGAIDYVLSYGIAEKPLLLLLVG ICYAAVYFIVFYVLIKALNLKTPGREDDDVDEVLDENTVQDVNENIMLKGLGGKENLQ TIDHCATRLRLTVKDTALVDEALLKKAGAKGVVKSGGQSVQVIIGPNVEFAAEELRAA VK*" /label="nagP CDS" gene 790233..791591 /gene="nagP" /locus_tag="BSU_07700" /old_locus_tag="BSU07700" /label="nagP gene" promotor_-10 complement(791227..791246) /Source="Nicolas_upshift_promotors" /id="U587" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1378 /SigmaFactorBS="gcgtttttaaattcaaagccttaatcagtacaTAAAACACGA taaagtatactgcCGCATAGCATATACCTACCAaaagcagaagcagcggtttttccgc g" /listShort="S268, mapB, S267, yflH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(791241) /Source="Nicolas_upshifts" /id="U587" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1378 /SigmaFactorBS="gcgtttttaaattcaaagccttaatcagtacaTAAAACACGA taaagtatactgcCGCATAGCATATACCTACCAaaagcagaagcagcggtttttccgc g" /listShort="S268, mapB, S267, yflH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(791260..791269) /Source="Nicolas_upshift_promotors" /id="U587" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1378 /SigmaFactorBS="gcgtttttaaattcaaagccttaatcagtacaTAAAACACGA taaagtatactgcCGCATAGCATATACCTACCAaaagcagaagcagcggtttttccgc g" /listShort="S268, mapB, S267, yflH" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 791477 /Source="Nicolas_upshifts" /id="D382" /incds=1 /nref=1 /ntot=106 /MaxReadThrough="3.67421" /MaxDrop="3.12268" /score="44.7832762" /energy="-16.9" /TU="U586" /idTUdmin="U586" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" downshifts 791587 /Source="Nicolas_upshifts" /id="D383" /incds=0 /nref=2 /ntot=87 /MaxReadThrough="2.54331" /MaxDrop="3.17508" /score="44.7832762" /energy="-16.9" /TU="NA" /idTUdmin="U586" /TUdmin=22 /isTUend="TRUE" /label="downshifts" CDS complement(791624..793573) /gene="ltaSB" /locus_tag="BSU_07710" /old_locus_tag="BSU07710" /function="16.1: Circulate" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10658653, 21255105" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10658653, 21255105; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enzyme responsible for polyglycerolphosphate LTAsynthesis" /protein_id="NP_388652.1" /db_xref="EnsemblGenomes-Gn:BSU07710" /db_xref="EnsemblGenomes-Tr:CAB12600" /db_xref="GOA:O34952" /db_xref="InterPro:IPR000917" /db_xref="InterPro:IPR012160" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="PDB:2W8D" /db_xref="SubtiList:BG12940" /db_xref="UniProtKB/Swiss-Prot:O34952" /translation="MKTFIKERGLAFFLIAVVLLWIKTYVGYVLNFNLGIDNTIQKIL LFVNPLSSSLFFLGFGLLFKKKLQQTAIIVIHFLMSFLLYANIVYYRFFNDFITIPVI MQAKTNGGQLGDSAFSLMRPTDAFYFIDTIILIILAIKVNKPAETSSKKSFRIIFASS ILVFLINLAVAESDRPELLTRSFDRNYLVKYLGTYNFTIYDAVQNIKSNSQRALADSS DVTEVENYMKANYDVPNNVYFGKAEGKNVIYVSLESLQSFIIDYKIDGKEVTPFLNKL AHDNETFYFDNFFHQTGQGKTSDAEFMMENSLYPLAQGSVFVNKAQNTLQSVPAILKS KNYTSATFHGNTQTFWNRNEMYKAEGIDKFFDSAYYDMNEENTKNYGMKDKPFFKESM PLLESLPQPFYTKFITLSNHFPFGMDEGDTDFPAGDFGDSVVDNYFQSAHYLDQSIEQ FFNDLKKDGLYDKSIIVMYGDHYGISENHNKAMAKVLGKDEITDYDNAQLQRVPLFIH AAGVKGEKVHKYAGDVDVAPTILHLLGVDTKDYLMSGSDILSKEHREVIPFRNGDFIS PKYTKISGKYYDTKTGKELDESEVDKSEDSLVKKELEMSDKIINGDLLRFYEPKGFKK VNPSDYDYTKHDEDSSETSKDNEDK*" /label="ltaSB CDS" gene complement(791624..793573) /gene="ltaSB" /locus_tag="BSU_07710" /old_locus_tag="BSU07710" /label="ltaSB gene" downshifts complement(791641) /Source="Nicolas_upshifts" /id="D384" /incds=0 /nref=219 /ntot=250 /MaxReadThrough="1.71031" /MaxDrop="6.08461" /score="43.6427282" /energy="-15.9" /TU="NA" /idTUdmin="U589" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 792683..792689 /Source="Nicolas_upshift_promotors" /id="U588" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=153 /SigmaFactorBS="acagagagttttccatcataaattcagcatcagaTGTTTTAc cttgtcccgtttggTGGAAAAAGTTATCAAAGTagaacgtttcgttatcatgtgccag t" /listShort="S269, yflD, yflB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 792705..792723 /Source="Nicolas_upshift_promotors" /id="U588" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=153 /SigmaFactorBS="acagagagttttccatcataaattcagcatcagaTGTTTTAc cttgtcccgtttggTGGAAAAAGTTATCAAAGTagaacgtttcgttatcatgtgccag t" /listShort="S269, yflD, yflB" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 792709..793673 /Source="Nicolas_S_feature" /locus_tag="new_843132_844096" /HighExp="Etha, Salt, Sw, Gly, C30, M9-stat, S8, B60, BC, S7" /AntisenseName="yflE" /AntisenseCor="-0.385555454026206" /AntisenseRegPval="-10.199999999999999" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S269" upshifts 792709 /Source="Nicolas_upshifts" /id="U588" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=153 /SigmaFactorBS="acagagagttttccatcataaattcagcatcagaTGTTTTAc cttgtcccgtttggTGGAAAAAGTTATCAAAGTagaacgtttcgttatcatgtgccag t" /listShort="S269, yflD, yflB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(793574..793648) /Source="Nicolas_S_feature" /locus_tag="new_843997_844071_c" /HighExp="Paraq, H2O2, LBGexp, G150, G135, G180, Lbexp, C30, LPhT, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S270" promotor_-10 complement(793625..793644) /Source="Nicolas_upshift_promotors" /id="U589" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.956043956043956" /psig=1 /xcortree=2614 /SigmaFactorBS="gattcgacggcgtttttcgccactttctccctcatacgattt tcACTTTtctaatctgctgattCGTGTTATATTGGATACGTTcgttttttctatcgtt t" /listShort="S270, yflE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(793648) /Source="Nicolas_upshifts" /id="U589" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.956043956043956" /psig=1 /xcortree=2614 /SigmaFactorBS="gattcgacggcgtttttcgccactttctccctcatacgattt tcACTTTtctaatctgctgattCGTGTTATATTGGATACGTTcgttttttctatcgtt t" /listShort="S270, yflE" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(793650..794172) /Source="Nicolas_S_feature" /locus_tag="new_844073_844595_c" /HighExp="S3, LoTm, S7, S4, S5, S8, S6, M9-stat, C30, Pyr" /AntisenseName="yflD" /AntisenseCor="0.24383322556613099" /AntisenseRegPval="-4.3" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S271" promotor_-35 complement(793660..793664) /Source="Nicolas_upshift_promotors" /id="U589" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.956043956043956" /psig=1 /xcortree=2614 /SigmaFactorBS="gattcgacggcgtttttcgccactttctccctcatacgattt tcACTTTtctaatctgctgattCGTGTTATATTGGATACGTTcgttttttctatcgtt t" /listShort="S270, yflE" /GFF_Attribute="listLong" /label="promotor_-35" CDS 793674..793811 /gene="yflD" /locus_tag="BSU_07720" /old_locus_tag="BSU07720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388653.1" /db_xref="EnsemblGenomes-Gn:BSU07720" /db_xref="EnsemblGenomes-Tr:CAB12601" /db_xref="SubtiList:BG12939" /db_xref="UniProtKB/Swiss-Prot:O34489" /translation="MREKVAKNAVESTFRFDITKCKTRYLSRNKGIKWYIENCMIKYK V*" /label="yflD CDS" gene 793674..793811 /gene="yflD" /locus_tag="BSU_07720" /old_locus_tag="BSU07720" /label="yflD gene" upshifts 793789 /Source="Nicolas_upshifts" /id="U590" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.895104895104895" /psig="0.952047952047952" /xcortree=589 /SigmaFactorBS="ccaaatgtaaaacaaggtatctttctagaaataaaggaataa aatggtacattgagaattgTATGATAAAATATAAGGTATagataaaaagaggtgaaat g" /listShort="yflB" /listLong="yflA, S272" /label="upshifts" misc_feature 793790..793809 /Source="Nicolas_upshift_promotors" /id="U590" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.895104895104895" /psig="0.952047952047952" /xcortree=589 /SigmaFactorBS="ccaaatgtaaaacaaggtatctttctagaaataaaggaataa aatggtacattgagaattgTATGATAAAATATAAGGTATagataaaaagaggtgaaat g" /listShort="yflB" /listLong="yflA, S272" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 793830..794222 /gene="yflB" /locus_tag="BSU_07735" /old_locus_tag="BSU07735" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388655.2" /db_xref="EnsemblGenomes-Gn:BSU07735" /db_xref="EnsemblGenomes-Tr:CAB12603" /db_xref="InterPro:IPR018961" /db_xref="SubtiList:BG12937" /db_xref="UniProtKB/Swiss-Prot:O34887" /translation="MDFSHIVSEDKIKRAIKDGDFQNLPGMGKPLPKDDAAHLPESLR MGYRILKNAGMAEDEGALKKELMTIDHLIEKCYDEKEREQLIRKKSEKQLLLDKLVDK KGMFSKPASAFYKNKVYDRLGRNRPSSS*" /label="yflB CDS" gene 793830..794222 /gene="yflB" /locus_tag="BSU_07735" /old_locus_tag="BSU07735" /label="yflB gene" promotor_-10 complement(794170..794188) /Source="Nicolas_upshift_promotors" /id="U591" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=999 /SigmaFactorBS="cgccatcctgcagacaagacaaatcagctggaagaaGGTCTG tttcgtccaagccggTCATATACTTTATTCTTATaaaaagcggatgctggctttgaaa a" /listShort="S271" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(794185) /Source="Nicolas_upshifts" /id="U591" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=999 /SigmaFactorBS="cgccatcctgcagacaagacaaatcagctggaagaaGGTCTG tttcgtccaagccggTCATATACTTTATTCTTATaaaaagcggatgctggctttgaaa a" /listShort="S271" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(794204..794209) /Source="Nicolas_upshift_promotors" /id="U591" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=999 /SigmaFactorBS="cgccatcctgcagacaagacaaatcagctggaagaaGGTCTG tttcgtccaagccggTCATATACTTTATTCTTATaaaaagcggatgctggctttgaaa a" /listShort="S271" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 794291..794297 /Source="Nicolas_upshift_promotors" /id="U592" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=234 /SigmaFactorBS="aaaagccatcctttttatgttccaagttctatgtcaaaaGGT TTATgtttttccatctatGGGAAATGATTCATAAACGaaaaaagggtgatgggatgga a" /listShort="yflA, S272" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 794312..794330 /Source="Nicolas_upshift_promotors" /id="U592" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=234 /SigmaFactorBS="aaaagccatcctttttatgttccaagttctatgtcaaaaGGT TTATgtttttccatctatGGGAAATGATTCATAAACGaaaaaagggtgatgggatgga a" /listShort="yflA, S272" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 794312 /Source="Nicolas_upshifts" /id="U592" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=234 /SigmaFactorBS="aaaagccatcctttttatgttccaagttctatgtcaaaaGGT TTATgtttttccatctatGGGAAATGATTCATAAACGaaaaaagggtgatgggatgga a" /listShort="yflA, S272" /GFF_Attribute="listLong" /label="upshifts" CDS 794347..795762 /gene="yflA" /locus_tag="BSU_07750" /old_locus_tag="BSU07750" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative aminoacid transporter" /protein_id="NP_388656.1" /db_xref="EnsemblGenomes-Gn:BSU07750" /db_xref="EnsemblGenomes-Tr:CAB12604" /db_xref="GOA:O34708" /db_xref="InterPro:IPR001463" /db_xref="SubtiList:BG12936" /db_xref="UniProtKB/Swiss-Prot:O34708" /translation="MERLLVWIEHISDWLWGPPLIILLTGTGLYFTILLKGFQFRYPL YIFKQTIGSVGKKPKGEGTVTPLQALTSALSSTIGAANIVGVPAAIMFGGPGAVFWMW LIALFAMAIKFSESVLAVHYREKNEQGEYVGGPMYYITKGLRMKWLGVFFSVALIVEL IPSIMVQGNSVSVSLAETFSFNKIYAGIGIAFLIGLVVIGGVKRIGKVTEFVVPLMAG AYAGAGLLIVLMNLSSVPAFFSLVFSNAFTSSSAVGGFAGAALAETVRWGFARGLYSN EAGMGTAPIAHAAAMTDHPVRQGFWSVIGIVIDTLIICTTTAFIVLASGVWTGKNASN DPAALTTAAFQHYFGSGGGYFVSVSLVFFVVSTIMVVIFYGVKQAEFLFGRLAGHVIK FVYLAAIIIGAAGGAKAIWGVLDLALVFIVVPNVIALLLLSRKVKALYTEFFTSEQYY LKDIRKTKQKPVYPTKEAKNS*" /label="yflA CDS" gene 794347..795762 /gene="yflA" /locus_tag="BSU_07750" /old_locus_tag="BSU07750" /label="yflA gene" downshifts complement(794348) /Source="Nicolas_upshifts" /id="D385" /incds=0 /nref=4 /ntot=16 /MaxReadThrough="0.76492" /MaxDrop="4.20973" /score="43.6427282" /energy="-15.9" /TU="NA" /idTUdmin="U593" /TUdmin=22 /isTUend="TRUE" /label="downshifts" promotor_no_box complement(794374..794474) /Source="Nicolas_upshift_promotors" /id="U593" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.723276723276723" /psig="0.006993006993007" /xcortree=122 /SigmaFactorBS="ggatagcgaaattgaaaacctttcagcaaaatagtgaaatac aagcccgtccccgtcagcaggatgattagcggcggaccccacagccaatcagatatat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(794414) /Source="Nicolas_upshifts" /id="U593" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.723276723276723" /psig="0.006993006993007" /xcortree=122 /SigmaFactorBS="ggatagcgaaattgaaaacctttcagcaaaatagtgaaatac aagcccgtccccgtcagcaggatgattagcggcggaccccacagccaatcagatatat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(795759..796835) /gene="yfkT" /locus_tag="BSU_07760" /old_locus_tag="BSU07760" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10762253, 15849754, 16850406, 23625846; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative spore germination integral inner membrane transporter" /protein_id="NP_388657.1" /db_xref="EnsemblGenomes-Gn:BSU07760" /db_xref="EnsemblGenomes-Tr:CAB12605" /db_xref="GOA:O34573" /db_xref="InterPro:IPR004761" /db_xref="SubtiList:BG12935" /db_xref="UniProtKB/Swiss-Prot:O34573" /translation="MDKTSAYQGLFFGALYTLAVGLKHAPILMIESAKQNAWHSYILG VVIVIPALWLMHRLMKKHQDKNIYELLSDSSPIAGRIIILLFSLYFLLINAHDIRFFI NLINILFLPRTPMAVLGGVIIFVAICIAREGKETLTRMAQIFLFPFGILVLFLPFTLA TQIELQNLTPVFEGLIPYLQSGYYAFGTMGELIILPLLFSNRSVPLKYTIFAILLGAL LLAVMLFSSISVFGPNLTSTFFDPAYMVIRQIRITDFLDRSDLIIAAFWIPVIMVKIA GSLYIVVYGLSFLHSKIDPKAMYTPTGMFSVVCGFWFFLNTNQLIDFNRIKPIINVVI SLLLPLLIYLIIKSKALFGAKAKH*" /label="yfkT CDS" gene complement(795759..796835) /gene="yfkT" /locus_tag="BSU_07760" /old_locus_tag="BSU07760" /label="yfkT gene" S_feature 795763..799129 /Source="Nicolas_S_feature" /locus_tag="new_846186_849552" /HighExp="Salt, Sw, Etha, LoTm, B36, Heat, LPhT, BC, T0.30H, H2O2" /AntisenseName="yfkR" /AntisenseCor="-1.3937740774571999E-3" /AntisenseRegPval=0 /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.952" /label="S272" CDS complement(796859..797059) /gene="yfkS" /locus_tag="BSU_07770" /old_locus_tag="BSU07770" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23625846; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="putative spore germination D protein" /protein_id="NP_388658.1" /db_xref="EnsemblGenomes-Gn:BSU07770" /db_xref="EnsemblGenomes-Tr:CAB12606" /db_xref="GOA:O35036" /db_xref="SubtiList:BG12934" /db_xref="UniProtKB/Swiss-Prot:O35036" /translation="MISYIVQTLIVCIAIYAYEWKNFRSANNLTKWAFSLLIAGSAFL WIYMRVNPLLPRLGHLFKYIPF*" /label="yfkS CDS" gene complement(796859..797059) /gene="yfkS" /locus_tag="BSU_07770" /old_locus_tag="BSU07770" /label="yfkS gene" CDS complement(797075..798229) /gene="yfkR" /locus_tag="BSU_07780" /old_locus_tag="BSU07780" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10762253, 23625846; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative spore germination protein" /protein_id="NP_388659.1" /db_xref="EnsemblGenomes-Gn:BSU07780" /db_xref="EnsemblGenomes-Tr:CAB12607" /db_xref="GOA:O35028" /db_xref="InterPro:IPR008844" /db_xref="SubtiList:BG12933" /db_xref="UniProtKB/Swiss-Prot:O35028" /translation="MKKTIYKCVLPLLICILLTGCWDRTEINDIAFVVSSAIDKKKDQ YRVAMQIPLVGQLGGQTGGGGGTAGSKTWYVDSASGTTIREANNKLQTSLSRTINTSH RRTVIIGEDMARDGVAPVFDILTRNPQNRLTALILVSRGEARDILNTDVQLEQFPAEM IRELAIIATSRPVFLSRFMSDLVEIGSDPYAPVISASKTKPGGKGKSNLKIDGLAIFK KDRLMDIFKDEHMTAALMLLNQARQPEFIVDLPNQMGQASIQLQKSNASFHAAEKNGK LSMTIEIRAKGIIMENQSTYETRENDQYYIIQKALNRTIKKDVISTVHRLQKLKADPA GFQDRTIRSTATTKNLLKKEWEEVYKDMEVHVVPIVTIEQGGVLYKTISH*" /label="yfkR CDS" gene complement(797075..798229) /gene="yfkR" /locus_tag="BSU_07780" /old_locus_tag="BSU07780" /label="yfkR gene" CDS complement(798210..799751) /gene="yfkQ" /locus_tag="BSU_07790" /old_locus_tag="BSU07790" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10762253, 23625846; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative spore germination protein" /protein_id="NP_388660.1" /db_xref="EnsemblGenomes-Gn:BSU07790" /db_xref="EnsemblGenomes-Tr:CAB12608" /db_xref="GOA:O34486" /db_xref="InterPro:IPR004995" /db_xref="SubtiList:BG12932" /db_xref="UniProtKB/Swiss-Prot:O34486" /translation="MNKRDKALQLIKELEDNQDRPISPNLKENLENLTLLTEGCSDIV FRQFDFGNGLCGFIVYIEGIVKSEHIQDHALRPFLMHLTDQIDEHEEALQNTLSISSV ALETSMSKVAASIIEGNAVLFADGHSKGLILNIKGGQRRSIEEPITESTIRGSREGFT ESLRVNTALVRFRVKTFQLKMISFKIGTKTKTDVVLAYIDGLADPKVIDKAKKRIKKI KIDAVLESGYIEEFIEDDTYSPFPQLQYTERPDTVAAQLLEGRFAIFTDNTPFVLTGP ITFWQLMQASEDYYERYLMSNLIRWLRYMFLFVALYLPAIYVAVITYHQDLMPTNLMF SVASAREPIPFPAIIEALIMEISFEALREAGVRLPKTIGQTVSILGALVIGTAAVEAG IVSAPMVIIVSLTGIASFTIPRFNLAISIRMLRFPLMFLASIFGIFGIMLGTIILVLH LCKLQSFGIPYLSGISPFKRDEVKDIFVRAPWWTMTRRPGTYSRGNGQKGAKREDPKD EENNI*" /label="yfkQ CDS" gene complement(798210..799751) /gene="yfkQ" /locus_tag="BSU_07790" /old_locus_tag="BSU07790" /label="yfkQ gene" promotor_-10 complement(799801..799812) /Source="Nicolas_upshift_promotors" /id="U594" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=879 /SigmaFactorBS="aacacttttttatagcgctttcatcctagtctGGAATATatg aaacagacaaGGTTACCCTAAAagtcacaagcacttattgaatatgacattaaaaagc a" /listShort="yfkQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(799804) /Source="Nicolas_upshifts" /id="U594" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=879 /SigmaFactorBS="aacacttttttatagcgctttcatcctagtctGGAATATatg aaacagacaaGGTTACCCTAAAagtcacaagcacttattgaatatgacattaaaaagc a" /listShort="yfkQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(799826..799832) /Source="Nicolas_upshift_promotors" /id="U594" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=879 /SigmaFactorBS="aacacttttttatagcgctttcatcctagtctGGAATATatg aaacagacaaGGTTACCCTAAAagtcacaagcacttattgaatatgacattaaaaagc a" /listShort="yfkQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 799861..799868 /Source="Nicolas_upshift_promotors" /id="U595" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=1569 /SigmaFactorBS="tccagactaggatgaaagcgctataaaaaagTGTTGACTacc tgtatatacagGAATACAATATGATTATAAGttgtatatacaagttataaaaacggat a" /listShort="treP, treA, treR, yfkO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 799883..799902 /Source="Nicolas_upshift_promotors" /id="U595" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=1569 /SigmaFactorBS="tccagactaggatgaaagcgctataaaaaagTGTTGACTacc tgtatatacagGAATACAATATGATTATAAGttgtatatacaagttataaaaacggat a" /listShort="treP, treA, treR, yfkO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 799890 /Source="Nicolas_upshifts" /id="U595" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=1569 /SigmaFactorBS="tccagactaggatgaaagcgctataaaaaagTGTTGACTacc tgtatatacagGAATACAATATGATTATAAGttgtatatacaagttataaaaacggat a" /listShort="treP, treA, treR, yfkO" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(799936) /Source="Nicolas_upshifts" /id="D386" /incds=0 /nref=1 /ntot=29 /MaxReadThrough="1.35091" /MaxDrop="3.57201" /score="22.8661179" /energy="-15.2" /TU="NA" /idTUdmin="U596" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 799944..801356 /gene="treP" /locus_tag="BSU_07800" /old_locus_tag="BSU07800" /EC_number="2.7.1.201" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 8755887, 8917076, 8969503, 18977770" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 8755887, 8917076, 8969503, 18977770; Product type t : transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) trehalose-specific enzyme IIBC component" /protein_id="NP_388661.1" /db_xref="EnsemblGenomes-Gn:BSU07800" /db_xref="EnsemblGenomes-Tr:CAB12609" /db_xref="GOA:P39794" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR004719" /db_xref="InterPro:IPR011296" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG11009" /db_xref="UniProtKB/Swiss-Prot:P39794" /translation="MGELNKSARQIVEAVGGAENIAAATHCVTRLRFALIDESKVDQE MLDQIDVVKGSFSTNGQFQVVIGQGTVNKVYAELVKETGIGESTKDEVKKASEKNMNP LQRAVKTLADIFIPILPAIVTAGLLMGINNILTAEGIFFSTKSIVQVYPQWADLANMI NLIAGTAFTFLPALIGWSAVKRFGGNPLLGIVLGVMLVHPDLLNAWGYGAAEQSGEIP VWNLFGLEVQKVGYQGQVLPILLASYMLAKIEVFLTKRTPEGIQLLVVAPITLLLTGF ASFIIIGPITFAIGNVLTSGLISVFGSFAALGGLLYGGFYSALVITGMHHTFLAVDLQ LIGSKLGGTFLWPMLALSNIAQGSAALAMMFIVKDEKQKGLSLTSGISAYLGITEPAI FGVNLRYRFPFIIAMVSSGLAGMYISSQGVLASSVGVGGVPGIFSIMSQYWGAFAIGM AIVLIVPFAGTYAYARFKHK*" /label="treP CDS" gene 799944..801356 /gene="treP" /locus_tag="BSU_07800" /old_locus_tag="BSU07800" /label="treP gene" promotor_no_box complement(799962..800062) /Source="Nicolas_upshift_promotors" /id="U596" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.66033966033966" /psig="0.0889110889110889" /xcortree=1570 /SigmaFactorBS="ttgctttcatctattaaagcaaaacgcaaacgtgtaacacaa tgagttgccgctgcaatattttcagcaccgccgactgcttcgacaatctgacgtgccg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(800002) /Source="Nicolas_upshifts" /id="U596" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.66033966033966" /psig="0.0889110889110889" /xcortree=1570 /SigmaFactorBS="ttgctttcatctattaaagcaaaacgcaaacgtgtaacacaa tgagttgccgctgcaatattttcagcaccgccgactgcttcgacaatctgacgtgccg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 801427..803112 /gene="treA" /locus_tag="BSU_07810" /old_locus_tag="BSU07810" /EC_number="3.2.1.93" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7651129, 7751281, 8755887, 8917076, 9701821, 26894535" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7651129, 7751281, 8755887, 8917076, 9701821, 26894535; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="trehalose-6-phosphate hydrolase" /protein_id="NP_388662.1" /db_xref="EnsemblGenomes-Gn:BSU07810" /db_xref="EnsemblGenomes-Tr:CAB12610" /db_xref="GOA:P39795" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR012769" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR032091" /db_xref="SubtiList:BG11010" /db_xref="UniProtKB/Swiss-Prot:P39795" /translation="MKTEQTPWWKKAVVYQIYPKSFNDTTGNGVGDLNGIIEKLDYLK TLQVDVLWLTPIYDSPQHDNGYDIRDYYSIYPEYGTMEDFERLVSEAHKRDLKVVMDL VVNHTSTEHKWFREAISSIDSPYRDFYIWKKPQENGSVPTNWESKFGGSAWELDEASG QYYLHLFDVTQADLNWENEEVRKHVYDMMHFWFEKGIDGFRLDVINLISKDQRFPNAE EGDGRSFYTDGPRVHEFLHEMNEKVFSHYDSMTVGEMSSTTVDHCIRYTNPDNKELDM TFSFHHLKVDYPNGEKWALAPFDFLKLKEILSDWQTGMHAGGGWNALFWCNHDQPRVV SRYGDDGAYRVKSAKMLATAIHMMQGTPYIYQGEELGMTNPKFTDISSYRDVESLNMY HAFKEKGMADQDITAILQAKSRDNSRTPVQWDATENGGFTTGTPWIPVAGNYREINAE AALRDQNSVFYHYQKLIQIRKMYDIVTEGTYEIIAKDDPNIFAYLRHGSNEKLLVINN FYGTEAAFTLPDSLAPDEWKAEVLLTNDEAREGLQNMTLRPYESIVYRLTKPC*" /label="treA CDS" gene 801427..803112 /gene="treA" /locus_tag="BSU_07810" /old_locus_tag="BSU07810" /label="treA gene" promotor_-10 complement(801733..801748) /Source="Nicolas_upshift_promotors" /id="U597" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1694 /SigmaFactorBS="tacgggctgtctattgaagagatcgcctcgCGAAACCATTtg tgctctgttgACGTATGATTGACAACaagatccatgacgactttcaggtctcttttat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(801740) /Source="Nicolas_upshifts" /id="U597" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1694 /SigmaFactorBS="tacgggctgtctattgaagagatcgcctcgCGAAACCATTtg tgctctgttgACGTATGATTGACAACaagatccatgacgactttcaggtctcttttat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(801761..801770) /Source="Nicolas_upshift_promotors" /id="U597" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1694 /SigmaFactorBS="tacgggctgtctattgaagagatcgcctcgCGAAACCATTtg tgctctgttgACGTATGATTGACAACaagatccatgacgactttcaggtctcttttat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 803085..803089 /Source="Nicolas_upshift_promotors" /id="U598" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2516 /SigmaFactorBS="ggcttcagaacatgacgcttcgcccatatgagtccatTGTTT atcgtttaacgaaacCGTGTTAAACTAAGCTGGGTggtccataatgaaggtgaataaa t" /listShort="treR, yfkO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 803105..803124 /Source="Nicolas_upshift_promotors" /id="U598" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2516 /SigmaFactorBS="ggcttcagaacatgacgcttcgcccatatgagtccatTGTTT atcgtttaacgaaacCGTGTTAAACTAAGCTGGGTggtccataatgaaggtgaataaa t" /listShort="treR, yfkO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 803108 /Source="Nicolas_upshifts" /id="U598" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2516 /SigmaFactorBS="ggcttcagaacatgacgcttcgcccatatgagtccatTGTTT atcgtttaacgaaacCGTGTTAAACTAAGCTGGGTggtccataatgaaggtgaataaa t" /listShort="treR, yfkO" /GFF_Attribute="listLong" /label="upshifts" CDS 803133..803849 /gene="treR" /locus_tag="BSU_07820" /old_locus_tag="BSU07820" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8755887, 9829827, 17705272" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8755887, 9829827, 17705272; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (TreR-trehalose)" /protein_id="NP_388663.1" /db_xref="EnsemblGenomes-Gn:BSU07820" /db_xref="EnsemblGenomes-Tr:CAB12611" /db_xref="GOA:P39796" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR011663" /db_xref="InterPro:IPR012770" /db_xref="InterPro:IPR028978" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2OGG" /db_xref="SubtiList:BG11011" /db_xref="UniProtKB/Swiss-Prot:P39796" /translation="MKVNKFITIYKDIAQQIEGGRWKAEEILPSEHELTAQYGTSRET VRKALHMLAQNGYIQKIRGKGSVVLNREKMQFPVSGLVSFKELAQTLGKETKTTVHKF GLEPPSELIQKQLRANLDDDIWEVIRSRKIDGEHVILDKDYFFRKHVPHLTKEICENS IYEYIEGELGLSISYAQKEIVAEPCTDEDRELLDLRGYDHMVVVRNYVFLEDTSLFQY TESRHRLDKFRFVDFARRGK*" /label="treR CDS" gene 803133..803849 /gene="treR" /locus_tag="BSU_07820" /old_locus_tag="BSU07820" /label="treR gene" downshifts 803842 /Source="Nicolas_upshifts" /id="D387" /incds=0 /nref=3 /ntot=115 /MaxReadThrough="6.58905" /MaxDrop="4.05981" /score="24.6748216" /energy="-11.1" /TU="U595,U598" /idTUdmin="U595" /TUdmin="-792" /isTUend="FALSE" /label="downshifts" promotor_-35 803924..803927 /Source="Nicolas_upshift_promotors" /id="U599" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.432567432567433" /psig="0.995004995004995" /xcortree=611 /SigmaFactorBS="caaaattgatactatccaacaaaaatgtgcgtACTTttactt tttatcataATGGCTACAATAGAGATGAGagtaatctaaaggagaggtgttttacatg g" /listShort="yfkO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 803943..803962 /Source="Nicolas_upshift_promotors" /id="U599" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.432567432567433" /psig="0.995004995004995" /xcortree=611 /SigmaFactorBS="caaaattgatactatccaacaaaaatgtgcgtACTTttactt tttatcataATGGCTACAATAGAGATGAGagtaatctaaaggagaggtgttttacatg g" /listShort="yfkO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 803952 /Source="Nicolas_upshifts" /id="U599" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.432567432567433" /psig="0.995004995004995" /xcortree=611 /SigmaFactorBS="caaaattgatactatccaacaaaaatgtgcgtACTTttactt tttatcataATGGCTACAATAGAGATGAGagtaatctaaaggagaggtgttttacatg g" /listShort="yfkO" /GFF_Attribute="listLong" /label="upshifts" CDS 803989..804654 /gene="hypO" /locus_tag="BSU_07830" /old_locus_tag="BSU07830" /EC_number="1.5.1.39" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15252706, 20727918, 20862523, 22238377, 26415543" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15252706, 20727918, 20862523, 22238377, 26415543; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NAD(P)H-flavin oxidoreductase (nitroreductase)" /protein_id="NP_388664.1" /db_xref="EnsemblGenomes-Gn:BSU07830" /db_xref="EnsemblGenomes-Tr:CAB12612" /db_xref="GOA:O34475" /db_xref="InterPro:IPR000415" /db_xref="InterPro:IPR029479" /db_xref="InterPro:IPR033878" /db_xref="SubtiList:BG12931" /db_xref="UniProtKB/Swiss-Prot:O34475" /translation="MADLKTQILDAYNFRHATKEFDPNKKVSDSDFEFILETGRLSPS SLGLEPWKFVVVQNPEFREKLREYTWGAQKQLPTASHFVLILARTAKDIKYNADYIKR HLKEVKQMPQDVYEGYLSKTEEFQKNDLHLLESDRTLFDWASKQTYIALGNMMTAAAQ IGVDSCPIEGFQYDHIHRILEEEGLLENGSFDISVMVAFGYRVRDPRPKTRSAVEDVV KWV*" /label="hypO CDS" gene 803989..804654 /gene="hypO" /locus_tag="BSU_07830" /old_locus_tag="BSU07830" /label="hypO gene" downshifts 804635 /Source="Nicolas_upshifts" /id="D388" /incds=0 /nref=180 /ntot=269 /MaxReadThrough="0.70079" /MaxDrop="6.77615" /score="34.5750428" /energy="-16.9" /TU="NA" /idTUdmin="U595" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(804691..809079) /gene="yfkN" /locus_tag="BSU_07840" /old_locus_tag="BSU07840" /EC_number="3.1.4.16" /EC_number="3.1.3.5" /EC_number="3.1.3.6" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14688230, 16291680, 21800427, 21906378, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported 2',3'-cyclic-nucleotide 2'-phosphodiesterase, 2' (or 3') nucleotidase and 5' nucleotidase" /protein_id="NP_388665.1" /db_xref="EnsemblGenomes-Gn:BSU07840" /db_xref="EnsemblGenomes-Tr:CAB12613" /db_xref="GOA:O34313" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR006146" /db_xref="InterPro:IPR006179" /db_xref="InterPro:IPR008334" /db_xref="InterPro:IPR029052" /db_xref="InterPro:IPR036907" /db_xref="PDB:3GVE" /db_xref="SubtiList:BG12930" /db_xref="UniProtKB/Swiss-Prot:O34313" /translation="MRIQKRRTHVENILRILLPPIMILSLILPTPPIHAEESAAPQVH LSILATTDIHANMMDYDYYSDKETADFGLARTAQLIQKHREQNPNTLLVDNGDLIQGN PLGEYAVKYQKDDIISGTKTHPIISVMNALKYDAGTLGNHEFNYGLDFLDGTIKGADF PIVNANVKTTSGENRYTPYVINEKTLIDENGNEQKVKVGYIGFVPPQIMTWDKKNLEG QVQVQDIVESANETIPKMKAEGADVIIALAHTGIEKQAQSSGAENAVFDLATKTKGID AIISGHQHGLFPSAEYAGVAQFNVEKGTINGIPVVMPSSWGKYLGVIDLKLEKADGSW KVADSKGSIESIAGNVTSRNETVTNTIQQTHQNTLEYVRKPVGKTEADINSFFAQVKD DPSIQIVTDAQKWYAEKEMKDTEYKNLPILSAGAPFKAGGRNGANYYTNIPAGDLAIK NVGDLYLYDNTVQIVKLTGSEVKDWLEMSAGQFNQIDPAKGGDQALLNENFRSYNFDV IDGVTYQVDVTKPAKYNENGKVINADSSRIINLSYEGKPISPSQEFLVVTNNYRASGG GGFPHLTSDKIVHGSAVENRQVLMDYIIEQKTVNPKADNNWSIAPVSGTNLTFESSLL AKPFADKADDVAYVGKSANEGYGVYKLQFDDDSNPDPPKDGLWDLTVMHTNDTHAHLD DAARRMTKINEVRSETNHNILLDAGDVFSGDLYFTKWNGLADLKMMNMMGYDAMTFGN HEFDKGPTVLSDFLSGNSATVDPANRYHFEAPEFPIVSANVDVSNEPKLKSFVKKPQT FTAGEKKEAGIHPYILLDVDGEKVAVFGLTTEDTATTSSPGKSIVFNDAFETAQNTVK AIQEEEKVNKIIALTHIGHNRDLELAKKVKGIDLIIGGHTHTLVDKMEVVNNEEPTIV AQAKEYGQFLGRVDVAFDEKGVVQTDKSNLSVLPIDEHTEENPEAKQELDQFKNELED VKNEKVGYTDVALDGQREHVRTKETNLGNFIADGMLAKAKEAAGARIAITNGGGIRAG IDKGDITLGEVLNVMPFGNTLYVADLTGKQIKEALEQGLSNVENGGGAFPQVAGIEYT FTLNNKPGHRVLEVKIESPNGDKVAINTDDTYRVATNNFVGAGGDGYSVFTEASHGED LGYVDYEIFTEQLKKLGNKVSPKVEGRIKEVFLPTKQKDGSWTLDEDKFAIYAKNANT PFVYYGIHEGSQEKPINLKVKKDQVKLLKERESDPSLTMFNYWYSMKMPMANLKTADT AIGIKSTGELDVSLSDVYDFTVKQKGKEIKSFKEPVQLSLRMFDIEEAHNPAIYHVDR KKKAFTKTGHGSVDDDMVTGYTNHFSEYTILNSGSNNKPPAFPSDQPTGGDDGNHGGG SDKPGGKQPTDGNGGNDTPPGTQPTNGSGGNGSGGSGTDGPAGGLLPDTATSMYSILL AGFLISALGTAMYLHQRRKQNRANQA*" /label="yfkN CDS" gene complement(804691..809079) /gene="yfkN" /locus_tag="BSU_07840" /old_locus_tag="BSU07840" /label="yfkN gene" downshifts complement(804710) /Source="Nicolas_upshifts" /id="D389" /incds=0 /nref=155 /ntot=229 /MaxReadThrough="1.00159" /MaxDrop="7.08591" /score="22.8661179" /energy="-15.2" /TU="NA" /idTUdmin="U600" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(809112..809131) /Source="Nicolas_upshift_promotors" /id="U600" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.944055944055944" /psig="0.994005994005994" /xcortree=462 /SigmaFactorBS="actcatttttctcccttttacaataatcataaagaaacacCT ACaaatagttacaaaaTATTCTTACAATAGGAGCTGtaacacaaatttcgttgaaagg t" /listShort="yfkN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(809129) /Source="Nicolas_upshifts" /id="U600" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.944055944055944" /psig="0.994005994005994" /xcortree=462 /SigmaFactorBS="actcatttttctcccttttacaataatcataaagaaacacCT ACaaatagttacaaaaTATTCTTACAATAGGAGCTGtaacacaaatttcgttgaaagg t" /listShort="yfkN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(809146..809149) /Source="Nicolas_upshift_promotors" /id="U600" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.944055944055944" /psig="0.994005994005994" /xcortree=462 /SigmaFactorBS="actcatttttctcccttttacaataatcataaagaaacacCT ACaaatagttacaaaaTATTCTTACAATAGGAGCTGtaacacaaatttcgttgaaagg t" /listShort="yfkN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 809256..809262 /Source="Nicolas_upshift_promotors" /id="U601" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=231 /SigmaFactorBS="tgggcatttatgcttatcgtttgtcacaatcgcggaaTGTTT ATtttagtgtggctgGGGTAGAGTGTTTTATGTAgacatataaagcgggaggttatga a" /listShort="yfkM, S273, yfkJ, yfkI, yfkH, S275" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 809276..809294 /Source="Nicolas_upshift_promotors" /id="U601" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=231 /SigmaFactorBS="tgggcatttatgcttatcgtttgtcacaatcgcggaaTGTTT ATtttagtgtggctgGGGTAGAGTGTTTTATGTAgacatataaagcgggaggttatga a" /listShort="yfkM, S273, yfkJ, yfkI, yfkH, S275" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 809279 /Source="Nicolas_upshifts" /id="U601" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=231 /SigmaFactorBS="tgggcatttatgcttatcgtttgtcacaatcgcggaaTGTTT ATtttagtgtggctgGGGTAGAGTGTTTTATGTAgacatataaagcgggaggttatga a" /listShort="yfkM, S273, yfkJ, yfkI, yfkH, S275" /GFF_Attribute="listLong" /label="upshifts" CDS 809322..809840 /gene="sufLB" /locus_tag="BSU_07850" /old_locus_tag="BSU07850" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10220166, 12354229, 16181642, 17257049, 17933887, 24330391, 25283443, 25561404" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10220166, 12354229, 16181642, 17257049, 17933887, 24330391, 25283443, 25561404; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="general stress protein 18; deglycase" /protein_id="NP_388666.1" /db_xref="EnsemblGenomes-Gn:BSU07850" /db_xref="EnsemblGenomes-Tr:CAB12614" /db_xref="GOA:P80876" /db_xref="InterPro:IPR002818" /db_xref="InterPro:IPR006286" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG12929" /db_xref="UniProtKB/Swiss-Prot:P80876" /translation="MGKKIAVVLTYYFEDSEYTEPAKAFKEAGHELTVIEKEKGKTVK GKQGTAEVTVDASIDDVNSSDFDALLIPGGFSPDQLRADDRFVQFTKAFMTDKKPVFA ICHGPQLLINAKALDGRKATGYTSIRVDMENAGADVVDKEVVVCQDQLVTSRTPDDIP AFNRESLALLEK*" /label="sufLB CDS" gene 809322..809840 /gene="sufLB" /locus_tag="BSU_07850" /old_locus_tag="BSU07850" /label="sufLB gene" downshifts 809826 /Source="Nicolas_upshifts" /id="D390" /incds=0 /nref=35 /ntot=153 /MaxReadThrough="8.02255" /MaxDrop="6.97573" /score="42.2080398" /energy="-12.9" /TU="U601" /idTUdmin="U601" /TUdmin="-3542" /isTUend="FALSE" /label="downshifts" downshifts complement(809870) /Source="Nicolas_upshifts" /id="D391" /incds=0 /nref=22 /ntot=199 /MaxReadThrough="1.59285" /MaxDrop="3.61098" /score="31.1923457" /energy="-11.1" /TU="NA" /idTUdmin="U602" /TUdmin=10 /isTUend="TRUE" /label="downshifts" S_feature 809871..811521 /Source="Nicolas_S_feature" /locus_tag="new_860294_861944" /HighExp="Etha, S6, S8, S5, S7, Gly, Salt, LoTm, S4, Diami" /AntisenseName="yfkL" /AntisenseCor="-0.52109661167911703" /AntisenseRegPval="-19.399999999999999" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S273" CDS complement(809880..811070) /gene="yfkL" /locus_tag="BSU_07860" /old_locus_tag="BSU07860" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16828913, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="efflux transporter" /protein_id="NP_388667.1" /db_xref="EnsemblGenomes-Gn:BSU07860" /db_xref="EnsemblGenomes-Tr:CAB12615" /db_xref="GOA:O34597" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12928" /db_xref="UniProtKB/Swiss-Prot:O34597" /translation="MQTTSIKTASGMYINYFFLGMVNIILASNMSSLTKQWNTDPTGI SYVIAAIGFGKLLTYGISGVLSDKIGRKPLVVASAGIMAVFLVGIPLSPSYELAFVFA LLAGVANSAMDAGTYPALTELFPSASGSANVLVKAFMSVGAALLPLLITFLADHSMFY GFAFYLPAAVYLLNIIYLSTLSFPKKHKKPTNSGQQESPVFLSEPVFQKEGTALIIIG FTSTALFTVSQIWLPSYAQKAAGLAESASVQLLSYYSIGSLASVLLLAVLLNRWVKPV FITLLYPIITLCTLAVMLTVHIPVVLDITAFFLGFSTAGVFQITITLMTELFWKRKGT VTGIVATASSLASILLPIATGLIAKAGGIAHIFIFDFGIAVIGTAAAAFLYYRYKKLT GAQA*" /label="yfkL CDS" gene complement(809880..811070) /gene="yfkL" /locus_tag="BSU_07860" /old_locus_tag="BSU07860" /label="yfkL gene" S_feature complement(811071..811162) /Source="Nicolas_S_feature" /locus_tag="new_861494_861585_c" /HighExp="C90, MG 10, BMM, MG-0.2, MG t5, MG 5, MG-0.1, UNK1, HPh, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S274" CDS complement(811163..811378) /gene="yfkK" /locus_tag="BSU_07870" /old_locus_tag="BSU07870" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388668.1" /db_xref="EnsemblGenomes-Gn:BSU07870" /db_xref="EnsemblGenomes-Tr:CAB12616" /db_xref="InterPro:IPR009507" /db_xref="SubtiList:BG12927" /db_xref="UniProtKB/Swiss-Prot:O35019" /translation="MSSPNTETLTQMIEEISQKLNMLNVGVIKAEDFSDEKIEDLTYL HRMVMKKESFSPSEMQAIAQELASLRK*" /label="yfkK CDS" gene complement(811163..811378) /gene="yfkK" /locus_tag="BSU_07870" /old_locus_tag="BSU07870" /label="yfkK gene" downshifts complement(811222) /Source="Nicolas_upshifts" /id="D392" /incds=0 /nref=1 /ntot=131 /MaxReadThrough="3.65318" /MaxDrop="2.45155" /score="16.183887" /energy="-11.6" /TU="U602" /idTUdmin="U602" /TUdmin="-1342" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(811410..811429) /Source="Nicolas_upshift_promotors" /id="U602" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.593406593406593" /psig="0.994005994005994" /xcortree=3074 /SigmaFactorBS="tcacttttttggaatgaacagcctgcttttagaatagggTTt ttttctgatggaaTTCTGTTAGAATAAAACATAcctatattgcgcatagaaaggatgg a" /listShort="yfkK, S274, yfkL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(811424) /Source="Nicolas_upshifts" /id="U602" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.593406593406593" /psig="0.994005994005994" /xcortree=3074 /SigmaFactorBS="tcacttttttggaatgaacagcctgcttttagaatagggTTt ttttctgatggaaTTCTGTTAGAATAAAACATAcctatattgcgcatagaaaggatgg a" /listShort="yfkK, S274, yfkL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(811444..811445) /Source="Nicolas_upshift_promotors" /id="U602" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.593406593406593" /psig="0.994005994005994" /xcortree=3074 /SigmaFactorBS="tcacttttttggaatgaacagcctgcttttagaatagggTTt ttttctgatggaaTTCTGTTAGAATAAAACATAcctatattgcgcatagaaaggatgg a" /listShort="yfkK, S274, yfkL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 811491..811498 /Source="Nicolas_upshift_promotors" /id="U603" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.82017982017982" /psig="0.994005994005994" /xcortree=134 /SigmaFactorBS="gctgttcattccaaaaaagtgaagacatCAGTTGAAaagaaa atgaacatCCTACTAAGATATTCATGAAggtttctttttagagaaataggggcaaaga a" /listShort="yfkJ, yfkI, yfkH, S275" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 811513..811532 /Source="Nicolas_upshift_promotors" /id="U603" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.82017982017982" /psig="0.994005994005994" /xcortree=134 /SigmaFactorBS="gctgttcattccaaaaaagtgaagacatCAGTTGAAaagaaa atgaacatCCTACTAAGATATTCATGAAggtttctttttagagaaataggggcaaaga a" /listShort="yfkJ, yfkI, yfkH, S275" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 811523 /Source="Nicolas_upshifts" /id="U603" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.82017982017982" /psig="0.994005994005994" /xcortree=134 /SigmaFactorBS="gctgttcattccaaaaaagtgaagacatCAGTTGAAaagaaa atgaacatCCTACTAAGATATTCATGAAggtttctttttagagaaataggggcaaaga a" /listShort="yfkJ, yfkI, yfkH, S275" /GFF_Attribute="listLong" /label="upshifts" CDS 811581..812051 /gene="yfkJ" /locus_tag="BSU_07880" /old_locus_tag="BSU07880" /EC_number="3.1.3.48" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15995210" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15995210; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein-tyrosine-phosphatase" /protein_id="NP_388669.1" /db_xref="EnsemblGenomes-Gn:BSU07880" /db_xref="EnsemblGenomes-Tr:CAB12617" /db_xref="GOA:O35016" /db_xref="InterPro:IPR017867" /db_xref="InterPro:IPR023485" /db_xref="InterPro:IPR036196" /db_xref="PDB:4ETM" /db_xref="SubtiList:BG12926" /db_xref="UniProtKB/Swiss-Prot:O35016" /translation="MISVLFVCLGNICRSPMAEAIFRDLAAKKGLEGKIKADSAGIGG WHIGNPPHEGTQEILRREGISFDGMLARQVSEQDLDDFDYIIAMDAENIGSLRSMAGF KNTSHIKRLLDYVEDSDLADVPDPYYTGNFEEVCQLIKTGCEQLLASIQKEKQL*" /label="yfkJ CDS" gene 811581..812051 /gene="yfkJ" /locus_tag="BSU_07880" /old_locus_tag="BSU07880" /label="yfkJ gene" CDS 812069..812389 /gene="yfkI" /locus_tag="BSU_07890" /old_locus_tag="BSU07890" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15995210" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388670.1" /db_xref="EnsemblGenomes-Gn:BSU07890" /db_xref="EnsemblGenomes-Tr:CAB12618" /db_xref="SubtiList:BG12925" /db_xref="UniProtKB/Swiss-Prot:O34418" /translation="MNNERLMLKGIFLGAAAGAALSLLHKPTRQACGMRWLTCKHKLS LYKSNPELLKNTVITKVDEAKKLARTLSKEVDFVNQQVKELKKTTPQVMELVQETKEH FSKK*" /label="yfkI CDS" gene 812069..812389 /gene="yfkI" /locus_tag="BSU_07890" /old_locus_tag="BSU07890" /label="yfkI gene" CDS 812413..813240 /gene="rbn" /locus_tag="BSU_07900" /old_locus_tag="BSU07900" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11222749, 12794188, 15849754, 16850406, 15764599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ribonuclease BN" /protein_id="NP_388671.1" /db_xref="EnsemblGenomes-Gn:BSU07900" /db_xref="EnsemblGenomes-Tr:CAB12619" /db_xref="GOA:O34437" /db_xref="InterPro:IPR017039" /db_xref="SubtiList:BG12924" /db_xref="UniProtKB/Swiss-Prot:O34437" /translation="MSFLKELFSRYTLHEGQSKSAELAYFFLLSLFPFLIFMLTLTAY LPLSTDDVLGVIEQYAPASAMSLVESITHQTLNNRNGGLLSFGIIAALWSASNGMNAI VRSLNHAYDVEENRSFIIVRLTSIFLTIAMVFTILVALLLPVFGREIGRLASDFVGAS DLFLSVWAAIRWGVSPLVLLIVFSALYVIAPNKKLSLRFVMPGAVFATIGWIIVSTLF SFYVSTFANYSATYGSIGGIIVLMIWFYLSGILIILGGEINALLHKRKKLPDENPYH* " /label="rbn CDS" gene 812413..813240 /gene="rbn" /locus_tag="BSU_07900" /old_locus_tag="BSU07900" /label="rbn gene" promotor_-35 813219..813225 /Source="Nicolas_upshift_promotors" /id="U604" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=847 /SigmaFactorBS="acataaacgtaaaaagcttccTGATGAAaatccctaccatta GCGCACCCTATAaacgaacttcggttcaaaaagaagtcggggggatatcgtgatgacc a" /listShort="S275" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 813240..813251 /Source="Nicolas_upshift_promotors" /id="U604" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=847 /SigmaFactorBS="acataaacgtaaaaagcttccTGATGAAaatccctaccatta GCGCACCCTATAaacgaacttcggttcaaaaagaagtcggggggatatcgtgatgacc a" /listShort="S275" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 813258..813414 /Source="Nicolas_S_feature" /locus_tag="new_863681_863837" /HighExp="S8, Etha, S6, Salt, S7, S5, ferm, nit, BT, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99976299999999996" /TUshortSig="SigGF, SigA, SigB" /TUshortPSig="0.974, 0.994, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S275" upshifts 813258 /Source="Nicolas_upshifts" /id="U604" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=847 /SigmaFactorBS="acataaacgtaaaaagcttccTGATGAAaatccctaccatta GCGCACCCTATAaacgaacttcggttcaaaaagaagtcggggggatatcgtgatgacc a" /listShort="S275" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(813290) /Source="Nicolas_upshifts" /id="D393" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="1.22239" /MaxDrop="3.61507" /score="-5.45682213" /energy="-3" /TU="NA" /idTUdmin="U606" /TUdmin=440 /isTUend="FALSE" /label="downshifts" downshifts 813389 /Source="Nicolas_upshifts" /id="D394" /incds=0 /nref=144 /ntot=253 /MaxReadThrough="1.4253" /MaxDrop="6.85849" /score="25.8200126" /energy="-17.9" /TU="NA" /idTUdmin="U603" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(813439..814614) /gene="yfkF" /locus_tag="BSU_07910" /old_locus_tag="BSU07910" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388672.1" /db_xref="EnsemblGenomes-Gn:BSU07910" /db_xref="EnsemblGenomes-Tr:CAB12620" /db_xref="GOA:O34929" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12923" /db_xref="UniProtKB/Swiss-Prot:O34929" /translation="MSRFHFFILVLLVSISGFSQGMLLPVISIIFETNGESAAINGLH ATGLYIGVLLASPFMEAPLRKLGFKPLIVMGGSIVILSLFGFIWLQSVWVWFLLRLFI GIGDHMLHFSTQTWVTSMSSKQNRGRNLSIYGLSFGLGFAAGPFMVPLVKLSPSLPFI VSGCISLFAWLFVFFLQNAYPETSPHETKSDNSFRRFYQAMLFGWVAFMPTFGYGFLE TALNGSFPVYALRLGISVDAVAIILPAFAIGSIIFQFPLGILSDKYGRRNVLLVILLT GALCFFIAGVFPSPYVIGGCFFIAGMAVGSTFTLGISYMTDLLPPHLLPAGNLLCGIT FSLGSILGPVAGGWYMQTFESANLFYFITLTLSSVWLALVLGKPKSWSPAETYSSSS* " /label="yfkF CDS" gene complement(813439..814614) /gene="yfkF" /locus_tag="BSU_07910" /old_locus_tag="BSU07910" /label="yfkF gene" downshifts complement(813444) /Source="Nicolas_upshifts" /id="D395" /incds=0 /nref=1 /ntot=97 /MaxReadThrough="0.37084" /MaxDrop="3.28031" /score="3.2266059" /energy="-14.1" /TU="NA" /idTUdmin="U606" /TUdmin=286 /isTUend="FALSE" /label="downshifts" promotor_-35 814051..814057 /Source="Nicolas_upshift_promotors" /id="U605" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=204 /SigmaFactorBS="cctgataaaatcgcctgaaactattgtctgatttGGTTTCAt gaggactggtttccGGGTATGCATTTTGTAGAAagaaaacaaaaagccacgcaaacag a" /listShort="S276, yfkE, yfkD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 814073..814091 /Source="Nicolas_upshift_promotors" /id="U605" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=204 /SigmaFactorBS="cctgataaaatcgcctgaaactattgtctgatttGGTTTCAt gaggactggtttccGGGTATGCATTTTGTAGAAagaaaacaaaaagccacgcaaacag a" /listShort="S276, yfkE, yfkD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 814077..814730 /Source="Nicolas_S_feature" /locus_tag="new_864500_865153" /HighExp="Etha, M9-stat, Salt, Sw, Gly, B60, Heat, LPhT, HiTm, T0.30H" /AntisenseName="yfkF" /AntisenseCor="-0.18505347560608301" /AntisenseRegPval="-2.6" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S276" upshifts 814077 /Source="Nicolas_upshifts" /id="U605" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=204 /SigmaFactorBS="cctgataaaatcgcctgaaactattgtctgatttGGTTTCAt gaggactggtttccGGGTATGCATTTTGTAGAAagaaaacaaaaagccacgcaaacag a" /listShort="S276, yfkE, yfkD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(814639..814658) /Source="Nicolas_upshift_promotors" /id="U606" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=3138 /SigmaFactorBS="gagggcaaatgtatagcgtgatataggcttttttcAGGTTGC CtgcttttggaaaaCGTTGTACGATCAACATAGAttccatataaggagaactgacacg a" /listShort="yfkF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(814654) /Source="Nicolas_upshifts" /id="U606" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=3138 /SigmaFactorBS="gagggcaaatgtatagcgtgatataggcttttttcAGGTTGC CtgcttttggaaaaCGTTGTACGATCAACATAGAttccatataaggagaactgacacg a" /listShort="yfkF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(814672..814679) /Source="Nicolas_upshift_promotors" /id="U606" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=3138 /SigmaFactorBS="gagggcaaatgtatagcgtgatataggcttttttcAGGTTGC CtgcttttggaaaaCGTTGTACGATCAACATAGAttccatataaggagaactgacacg a" /listShort="yfkF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 814720..814725 /Source="Nicolas_upshift_promotors" /id="U607" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.848151848151848" /psig="0.848151848151848" /xcortree=1179 /SigmaFactorBS="ggcaacctgaaaaaagcctatatcacgctatacatttgccct cgtgtaATCATGaaggtttttgtgaaGAATAAAAATAAAACAAGTcataaaaaaggag c" /listShort="yfkE" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 814732 /Source="Nicolas_upshifts" /id="U607" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.848151848151848" /psig="0.848151848151848" /xcortree=1179 /SigmaFactorBS="ggcaacctgaaaaaagcctatatcacgctatacatttgccct cgtgtaATCATGaaggtttttgtgaaGAATAAAAATAAAACAAGTcataaaaaaggag c" /listShort="yfkE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 814740..814758 /Source="Nicolas_upshift_promotors" /id="U607" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.848151848151848" /psig="0.848151848151848" /xcortree=1179 /SigmaFactorBS="ggcaacctgaaaaaagcctatatcacgctatacatttgccct cgtgtaATCATGaaggtttttgtgaaGAATAAAAATAAAACAAGTcataaaaaaggag c" /listShort="yfkE" /GFF_Attribute="listLong" /label="promotor_-10" CDS 814782..815837 /gene="chaA" /locus_tag="BSU_07920" /old_locus_tag="BSU07920" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 19543710, 23798403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 19543710, 23798403; Product type t: transporter" /codon_start=1 /transl_table=11 /product="H+/Ca2+ antiporter" /protein_id="NP_388673.1" /db_xref="EnsemblGenomes-Gn:BSU07920" /db_xref="EnsemblGenomes-Tr:CAB12621" /db_xref="GOA:O34840" /db_xref="InterPro:IPR004713" /db_xref="InterPro:IPR004798" /db_xref="InterPro:IPR004837" /db_xref="PDB:4KJR" /db_xref="PDB:4KJS" /db_xref="SubtiList:BG12922" /db_xref="UniProtKB/Swiss-Prot:O34840" /translation="MNRIFFILVAAGVPLSVIGSLMHWPSAVLFAVYCVTIIALASYM GRATESLSIIAGPRIGGLLNATFGNAVELIISLFALKEGLTGIVLASLTGSVLGNLLL VAGLSFFVGGLKYKRQEFNIHDARHNSGLLIFAIIVAFVIPEVFSVGMGNASKLNLSI GISIIMILLYVAALYFKLVTHRGVYQPNNAAQTEEEEEPEWSGKVATIVLFAATIVVA YISENLVHTFHSVAEQFGWSELFIGVIIVAIVGNAAEHASAIIMAFKNKMDIAVEIAV GSTLQIAMFVAPVLVICSIFFPTSMPLVFTLPELVAMVSAVLLMIAISNDGDSNWFEG ATLLAAYVIMAIGFFLL*" /label="chaA CDS" gene 814782..815837 /gene="chaA" /locus_tag="BSU_07920" /old_locus_tag="BSU07920" /label="chaA gene" promotor_-35 815851..815857 /Source="Nicolas_upshift_promotors" /id="U608" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=931 /SigmaFactorBS="gatcggctttttccttctttaacctgaaaaaatgaTGGATAA caacaaagcgggatGAAAAGACTAAGggaaaatgccatagaaagagtgatatgatgaa a" /listShort="yfkD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 815872..815883 /Source="Nicolas_upshift_promotors" /id="U608" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=931 /SigmaFactorBS="gatcggctttttccttctttaacctgaaaaaatgaTGGATAA caacaaagcgggatGAAAAGACTAAGggaaaatgccatagaaagagtgatatgatgaa a" /listShort="yfkD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 815876 /Source="Nicolas_upshifts" /id="U608" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=931 /SigmaFactorBS="gatcggctttttccttctttaacctgaaaaaatgaTGGATAA caacaaagcgggatGAAAAGACTAAGggaaaatgccatagaaagagtgatatgatgaa a" /listShort="yfkD" /GFF_Attribute="listLong" /label="upshifts" CDS 815908..816702 /gene="yfkD" /locus_tag="BSU_07930" /old_locus_tag="BSU07930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 19543710" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388674.1" /db_xref="EnsemblGenomes-Gn:BSU07930" /db_xref="EnsemblGenomes-Tr:CAB12622" /db_xref="InterPro:IPR025548" /db_xref="SubtiList:BG12921" /db_xref="UniProtKB/Swiss-Prot:O34579" /translation="MMKKLFHSTLIVLLFFSFFGVQPIHAKKQFKVPNSVASISKENT YPNASQDQPMLQPSKLAKELLDHSEVKIENPHLIKMLNESNISGTPLAVGYRATIFLG KWALGYESNETVANWEYKKINTNRADNRGGKETAEMHYAQEQQYRVKGGLTAKVPNAE DVKSMMMQKAMKKTNLPLAFETVIGAGTKRDQIYKVAPKKIGYLHAYAPAVNEKGKVT YGEVYLVLKGNKRKLVVKNVTSQGIGAWIPVQDHVTFGFQLSSLPR*" /label="yfkD CDS" gene 815908..816702 /gene="yfkD" /locus_tag="BSU_07930" /old_locus_tag="BSU07930" /label="yfkD gene" downshifts 816690 /Source="Nicolas_upshifts" /id="D396" /incds=0 /nref=41 /ntot=100 /MaxReadThrough="0.82657" /MaxDrop="5.7252" /score="28.7014976" /energy="-9.5" /TU="NA" /idTUdmin="U605" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(816741..817583) /gene="mscC" /locus_tag="BSU_07940" /old_locus_tag="BSU07940" /function="16.1: Circulate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17665170, 18310427, 19252899" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17665170, 18310427, 19252899; Product type t: transporter" /codon_start=1 /transl_table=11 /product="mechanosensitive ion channel" /protein_id="NP_388675.1" /db_xref="EnsemblGenomes-Gn:BSU07940" /db_xref="EnsemblGenomes-Tr:CAB12623" /db_xref="GOA:O35043" /db_xref="InterPro:IPR006685" /db_xref="InterPro:IPR010920" /db_xref="InterPro:IPR011014" /db_xref="SubtiList:BG12920" /db_xref="UniProtKB/Swiss-Prot:O35043" /translation="MRMKETLTEIFQNKIVDILLVAVILWIGVFIINRLVQLFFKRTD FIEEKKEKTIESLVRSVTQYTATIGFIFYVISLFVHDFGKILAGAGVAGIVIGFGAQS LIKDVLAGVFLIYERQLHKGDYVTVNNLFNGTVEEIGLRSLQIREWSGKLLTISNGEV RQIENYNIDFMRITESFLISFKEDPDRVYSVLEEACDMLNEELRDSLKRDEFGNPTEP FQIHGITALNKINRGVEFTVKGMVKDDDYFSASLAVRRVLVRQLYQNNVQMLEEAVRI ERTQ*" /label="mscC CDS" gene complement(816741..817583) /gene="mscC" /locus_tag="BSU_07940" /old_locus_tag="BSU07940" /label="mscC gene" downshifts complement(816743) /Source="Nicolas_upshifts" /id="D397" /incds=0 /nref=58 /ntot=230 /MaxReadThrough="1.96922" /MaxDrop="4.8789" /score="23.5281308" /energy="-9.8" /TU="NA" /idTUdmin="U609" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(817584..818705) /gene="yfkA" /locus_tag="BSU_07955" /old_locus_tag="BSU07955" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative Fe-S oxidoreductase, radical SAM superfamily" /protein_id="NP_388677.2" /db_xref="EnsemblGenomes-Gn:BSU07955" /db_xref="EnsemblGenomes-Tr:CAB12625" /db_xref="GOA:O34400" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR014866" /db_xref="InterPro:IPR031004" /db_xref="InterPro:IPR034395" /db_xref="SubtiList:BG12918" /db_xref="UniProtKB/Swiss-Prot:O34400" /translation="MTQNTKLRPITPEFDPWEAYMDVDQYGDMQLTNVEFTTTTLCNM RCEHCAVGYTLQPKDPNALPIDLLLKRLEEIPRLRSISITGGEPMLSLKSVKEYVVPL LKYAHERGVRTQINSNLTLDIERYEWIIPYLDVLHISHNWGTVEDFAEIGFAMMDRKP TFEQRARYFEKMIENSRTLVDAGVMVSAETMLNKRTLPHIEHIHRQITEDMKCQRHEV HPMYPSDFASALESLSLKEMRQAIHRLLDIRDENTWMLFGTLPFYACSPDEDDQKLLR RLRAAKNVTVRNDPDGRSRLNVNIFDGNIIVTDFGDTPPLGNIQTDSLPSAYEKWRET KLAKELSCHCPNVRCLGPNVLVKNSYYQDTDFTKRQARS*" /label="yfkA CDS" gene complement(817584..818705) /gene="yfkA" /locus_tag="BSU_07955" /old_locus_tag="BSU07955" /label="yfkA gene" promotor_-10 complement(818746..818765) /Source="Nicolas_upshift_promotors" /id="U609" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=2517 /SigmaFactorBS="atggtagctcattttttgccgtttttcaatcgccgcgctACT TGcgatcttggcaaatcAGGTCTAAAATTAACTGTTGgcagcgttagtatgcccattt a" /listShort="yfkA, yfkC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(818764) /Source="Nicolas_upshifts" /id="U609" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=2517 /SigmaFactorBS="atggtagctcattttttgccgtttttcaatcgccgcgctACT TGcgatcttggcaaatcAGGTCTAAAATTAACTGTTGgcagcgttagtatgcccattt a" /listShort="yfkA, yfkC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(818781..818785) /Source="Nicolas_upshift_promotors" /id="U609" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=2517 /SigmaFactorBS="atggtagctcattttttgccgtttttcaatcgccgcgctACT TGcgatcttggcaaatcAGGTCTAAAATTAACTGTTGgcagcgttagtatgcccattt a" /listShort="yfkA, yfkC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 818793..818800 /Source="Nicolas_upshift_promotors" /id="U610" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.537462537462537" /psig=1 /xcortree=574 /SigmaFactorBS="ctgatttgccaagatcgcaagtagcgcggCGATTGAAaaacg gcaaaaaaTGAGCTACCATAATAAAAAAtgaatggaggaacagaatggggaacgccgt a" /listShort="yfjT, pdaA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 818814..818833 /Source="Nicolas_upshift_promotors" /id="U610" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.537462537462537" /psig=1 /xcortree=574 /SigmaFactorBS="ctgatttgccaagatcgcaagtagcgcggCGATTGAAaaacg gcaaaaaaTGAGCTACCATAATAAAAAAtgaatggaggaacagaatggggaacgccgt a" /listShort="yfjT, pdaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 818824 /Source="Nicolas_upshifts" /id="U610" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.537462537462537" /psig=1 /xcortree=574 /SigmaFactorBS="ctgatttgccaagatcgcaagtagcgcggCGATTGAAaaacg gcaaaaaaTGAGCTACCATAATAAAAAAtgaatggaggaacagaatggggaacgccgt a" /listShort="yfjT, pdaA" /GFF_Attribute="listLong" /label="upshifts" CDS 818850..819035 /gene="yfjT" /locus_tag="BSU_07970" /old_locus_tag="BSU07970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388678.1" /db_xref="EnsemblGenomes-Gn:BSU07970" /db_xref="EnsemblGenomes-Tr:CAB12626" /db_xref="SubtiList:BG12916" /db_xref="UniProtKB/Swiss-Prot:O35041" /translation="MGNAVNNKDQQIDYLKNRLDMFMNVIDSLDPEATDVEDIDRLIS MLDDLEAKYERFKKDWE*" /label="yfjT CDS" gene 818850..819035 /gene="yfjT" /locus_tag="BSU_07970" /old_locus_tag="BSU07970" /label="yfjT gene" downshifts 819014 /Source="Nicolas_upshifts" /id="D398" /incds=0 /nref=15 /ntot=177 /MaxReadThrough="3.03457" /MaxDrop="3.24661" /score="14.1645187" /energy="-6.4" /TU="U610" /idTUdmin="U610" /TUdmin="-559" /isTUend="FALSE" /label="downshifts" promotor_-35 819078..819084 /Source="Nicolas_upshift_promotors" /id="U611" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.95004995004995" /psig="0.95004995004995" /xcortree=930 /SigmaFactorBS="gaataaaaccgcgtgcccgccgcggtttttttattggcataa agcaacAGTATAAaacaaagtctctatCTGTAAAATAAGaaaaaatgcagaaggagcg c" /listShort="pdaA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 819090 /Source="Nicolas_upshifts" /id="U611" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.95004995004995" /psig="0.95004995004995" /xcortree=930 /SigmaFactorBS="gaataaaaccgcgtgcccgccgcggtttttttattggcataa agcaacAGTATAAaacaaagtctctatCTGTAAAATAAGaaaaaatgcagaaggagcg c" /listShort="pdaA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 819099..819110 /Source="Nicolas_upshift_promotors" /id="U611" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.95004995004995" /psig="0.95004995004995" /xcortree=930 /SigmaFactorBS="gaataaaaccgcgtgcccgccgcggtttttttattggcataa agcaacAGTATAAaacaaagtctctatCTGTAAAATAAGaaaaaatgcagaaggagcg c" /listShort="pdaA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 819136..819927 /gene="pdaA" /locus_tag="BSU_07980" /old_locus_tag="BSU07980" /EC_number="3.5.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14679227, 15687192" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14679227, 15687192; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported peptidoglycan N-acetylmuramic acid deacetylase" /protein_id="NP_388679.1" /db_xref="EnsemblGenomes-Gn:BSU07980" /db_xref="EnsemblGenomes-Tr:CAB12627" /db_xref="GOA:O34928" /db_xref="InterPro:IPR002509" /db_xref="InterPro:IPR011330" /db_xref="InterPro:IPR014235" /db_xref="PDB:1NY1" /db_xref="PDB:1W17" /db_xref="PDB:1W1A" /db_xref="PDB:1W1B" /db_xref="SubtiList:BG12915" /db_xref="UniProtKB/Swiss-Prot:O34928" /translation="MKWMCSICCAAVLLAGGAAQAEAVPNEPINWGFKRSVNHQPPDA GKQLNSLIEKYDAFYLGNTKEKTIYLTFDNGYENGYTPKVLDVLKKHRVTGTFFVTGH FVKDQPQLIKRMSDEGHIIGNHSFHHPDLTTKTADQIQDELDSVNEEVYKITGKQDNL YLRPPRGVFSEYVLKETKRLGYQTVFWSVAFVDWKINNQKGKKYAYDHMIKQAHPGAI YLLHTVSRDNAEALDDAITDLKKQGYTFKSIDDLMFEKEMRLPSL*" /label="pdaA CDS" gene 819136..819927 /gene="pdaA" /locus_tag="BSU_07980" /old_locus_tag="BSU07980" /label="pdaA gene" downshifts 819925 /Source="Nicolas_upshifts" /id="D399" /incds=0 /nref=1 /ntot=36 /MaxReadThrough="2.12067" /MaxDrop="3.4013" /score="14.4741934" /energy="-10.2" /TU="NA" /idTUdmin="U611" /TUdmin=22 /isTUend="TRUE" /label="downshifts" CDS complement(819965..820825) /gene="yfjR" /locus_tag="BSU_07990" /old_locus_tag="BSU07990" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20512483; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative beta-hydroxyacid dehydrogenase" /protein_id="NP_388680.2" /db_xref="EnsemblGenomes-Gn:BSU07990" /db_xref="EnsemblGenomes-Tr:CAB12628" /db_xref="GOA:O34969" /db_xref="InterPro:IPR006115" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR015815" /db_xref="InterPro:IPR029154" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12914" /db_xref="UniProtKB/Swiss-Prot:O34969" /translation="MKIAVIGLGNMGQPIARNVLQAGYELTVYNRTKQKTEDLVTEGA QAADTPRLAAKSADIVITMLADDDSVSTVTFGEDGLLEGLAENGIHISMSTISVEFSE KLAAAHAEKGQFFLAAPVLGRPDAAAKAALRIITAGPAEAKQAAKPLLDSLSQQIFDV GEESKTANAAKISINFLLVSMLEALSESFLMMEKYGLEQKQFLEIASALFGSPVYQNY GTIMAEQKFEPAGFKMSLGLKDTNLALAAAKRVSANLPLAELAKSHFESGIEKGFGDL DWAALIKCIK*" /label="yfjR CDS" gene complement(819965..820825) /gene="yfjR" /locus_tag="BSU_07990" /old_locus_tag="BSU07990" /label="yfjR gene" downshifts complement(819979) /Source="Nicolas_upshifts" /id="D400" /incds=0 /nref=15 /ntot=193 /MaxReadThrough="2.61589" /MaxDrop="3.98341" /score="-1.3382901" /energy="-12.1" /TU="NA" /idTUdmin="U612" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(820845..820864) /Source="Nicolas_upshift_promotors" /id="U612" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=1961 /SigmaFactorBS="agcgagcagctgttcttttttgttgtaagccgatcgCTATgc atattctgttcatATTGTTTATAATGGAAAAAAtattcagggagtgattagattgaaa a" /listShort="yfjR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(820859) /Source="Nicolas_upshifts" /id="U612" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=1961 /SigmaFactorBS="agcgagcagctgttcttttttgttgtaagccgatcgCTATgc atattctgttcatATTGTTTATAATGGAAAAAAtattcagggagtgattagattgaaa a" /listShort="yfjR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(820880..820883) /Source="Nicolas_upshift_promotors" /id="U612" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=1961 /SigmaFactorBS="agcgagcagctgttcttttttgttgtaagccgatcgCTATgc atattctgttcatATTGTTTATAATGGAAAAAAtattcagggagtgattagattgaaa a" /listShort="yfjR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(820924..821883) /gene="yfjQ" /locus_tag="BSU_08000" /old_locus_tag="BSU08000" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14563871, 24415722; Product type t: transporter" /codon_start=1 /transl_table=11 /product="divalent cation (octahedral coordination) transporter" /protein_id="NP_388681.1" /db_xref="EnsemblGenomes-Gn:BSU08000" /db_xref="EnsemblGenomes-Tr:CAB12629" /db_xref="GOA:O31543" /db_xref="InterPro:IPR002523" /db_xref="InterPro:IPR004488" /db_xref="SubtiList:BG12913" /db_xref="UniProtKB/Swiss-Prot:O31543" /translation="MINITAITTEHQLLKNIPIERVEQPDIAWYWVDFYGPEDTETAL LRDFFHFHPLAIEDCFQHMQRPKLDHYDGYRFYVIHALNKETLETEEVDIFQGEKFVV TFHLHETPGIAKVRERLYASPDILKKGPGHISYMIMDQLVDEYFPLVYKIEDRLNEIE ESRPHKTYGTLMNEVFDLRTDLLHLRRTIIPMRDLLYRILSLDHVKEQRETKAYFSDI YDHLLKLSEIVESNRDMTSDLRDSYVTLNSNRMNAIMMTLTIVSTIFIPLTFIAGVYG MNFDFMPELHWKYGYFAVLGLMAALVIGMLIWFVHKGWFNIFK*" /label="yfjQ CDS" gene complement(820924..821883) /gene="yfjQ" /locus_tag="BSU_08000" /old_locus_tag="BSU08000" /label="yfjQ gene" downshifts complement(820947) /Source="Nicolas_upshifts" /id="D401" /incds=0 /nref=137 /ntot=224 /MaxReadThrough="2.29296" /MaxDrop="4.2496" /score="10.2736001" /energy="-7.5" /TU="NA" /idTUdmin="U613" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(821894..821913) /Source="Nicolas_upshift_promotors" /id="U613" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.888111888111888" /psig="0.993006993006993" /xcortree=1816 /SigmaFactorBS="tggaattaggcagagagtaccgtatACTTttctcataaagac cgCATGATATAATGGCAGGTGGagggttgtttatgatcaacattaccgcaatcacaac a" /listShort="yfjQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(821897) /Source="Nicolas_upshifts" /id="U613" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.888111888111888" /psig="0.993006993006993" /xcortree=1816 /SigmaFactorBS="tggaattaggcagagagtaccgtatACTTttctcataaagac cgCATGATATAATGGCAGGTGGagggttgtttatgatcaacattaccgcaatcacaac a" /listShort="yfjQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(821929..821932) /Source="Nicolas_upshift_promotors" /id="U613" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.888111888111888" /psig="0.993006993006993" /xcortree=1816 /SigmaFactorBS="tggaattaggcagagagtaccgtatACTTttctcataaagac cgCATGATATAATGGCAGGTGGagggttgtttatgatcaacattaccgcaatcacaac a" /listShort="yfjQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 821944..821948 /Source="Nicolas_upshift_promotors" /id="U614" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.832167832167832" /psig="0.999000999001" /xcortree=2271 /SigmaFactorBS="atgcggtctttatgagaaaagtatacggtactcTCTGCctaa ttccagcggCATGTTATACTGAACAAAAAcggaaaaaagggtggatctcatgtggaag g" /listShort="yfjP, S277, yfjO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 821962..821981 /Source="Nicolas_upshift_promotors" /id="U614" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.832167832167832" /psig="0.999000999001" /xcortree=2271 /SigmaFactorBS="atgcggtctttatgagaaaagtatacggtactcTCTGCctaa ttccagcggCATGTTATACTGAACAAAAAcggaaaaaagggtggatctcatgtggaag g" /listShort="yfjP, S277, yfjO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 821971 /Source="Nicolas_upshifts" /id="U614" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.832167832167832" /psig="0.999000999001" /xcortree=2271 /SigmaFactorBS="atgcggtctttatgagaaaagtatacggtactcTCTGCctaa ttccagcggCATGTTATACTGAACAAAAAcggaaaaaagggtggatctcatgtggaag g" /listShort="yfjP, S277, yfjO" /GFF_Attribute="listLong" /label="upshifts" CDS 822002..822865 /gene="yfjP" /locus_tag="BSU_08010" /old_locus_tag="BSU08010" /EC_number="3.2.2.21" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative DNA-3-methyladenine glycosylase" /protein_id="NP_388682.1" /db_xref="EnsemblGenomes-Gn:BSU08010" /db_xref="EnsemblGenomes-Tr:CAB12630" /db_xref="GOA:O31544" /db_xref="InterPro:IPR003265" /db_xref="InterPro:IPR011257" /db_xref="InterPro:IPR023170" /db_xref="SubtiList:BG12912" /db_xref="UniProtKB/Swiss-Prot:O31544" /translation="MWKEKVSVTPPYHFDRVLDRLSLDPLNAVDREAREVRVPIRNQA GDVCIVKVQALGHAGEPEFLVSGETDQGEMMKEIKRIFQWENHLQHVLDHFSKTSLSA IFEEHAGTPLVLDYSVYNCMMKCIIHQQLNLSFAYTLTERFVHAFGEQKDGVWCYPKP ETIAELDYQDLRDLQFSMRKAEYTIDTSRMIAEGTLSLSELPHMADEDIMKKLIKIRG IGPWTVQNVLMFGLGRPNLFPLADIGLQNAIKRHFQLDDKPAKDVMLAMSKEWEPYLS YASLYLWRSIE*" /label="yfjP CDS" gene 822002..822865 /gene="yfjP" /locus_tag="BSU_08010" /old_locus_tag="BSU08010" /label="yfjP gene" S_feature 822866..822978 /Source="Nicolas_S_feature" /locus_tag="new_873289_873401" /HighExp="BC, M40t90, LBGtran, C90, M9-stat, M0t90, Lbtran, Sw, M40t45, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S277" CDS 822979..824379 /gene="yfjO" /locus_tag="BSU_08020" /old_locus_tag="BSU08020" /EC_number="2.1.1.-" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA methyltransferase" /protein_id="NP_388683.1" /db_xref="EnsemblGenomes-Gn:BSU08020" /db_xref="EnsemblGenomes-Tr:CAB12631" /db_xref="GOA:O31545" /db_xref="InterPro:IPR001566" /db_xref="InterPro:IPR002792" /db_xref="InterPro:IPR010280" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR030390" /db_xref="InterPro:IPR030391" /db_xref="SubtiList:BG12911" /db_xref="UniProtKB/Swiss-Prot:O31545" /translation="MNQQKKQAPVELKVGQTFPLTIKRLGINGEGVGYFKKKVVFVPG ALPGEEVVVQATKVQPKFSEGRIKKIRKASEHRVAPPCPVYEQCGGCQLQHLAYSQQL REKRDIVIQSLERHTKFKVENMEIKETIGMDNPWNYRNKSQFQIGRSQSGSIIAGLYG LDSHDIVPIKDCIVQHPATNKTTGIVRRILEDFNVSVYNERKRKGDVRTIVTRVGFET GEVQVVLVTAKETLPHKEEIVKAIQKRLPEVKSIIQNVNGAKTSVIFGEKTKQLAGKT VIQEVLGDVSFELSARAFFQLNPEQTVKLYDEVKKAAQLTGKEKVVDAYCGVGTIGMW VADGAKEVRGMDVIKESIDDAKKNAKKHGMANATYVTGTAEHWLPKWTKEGFRPDVVI VDPPRTGCDSTFLDTIKKVKPKRFVYVSCNPSTLAKDLQTLSKDYRVDYIQPVDMFPQ TAHVEAVARLVLKSSN*" /label="yfjO CDS" gene 822979..824379 /gene="yfjO" /locus_tag="BSU_08020" /old_locus_tag="BSU08020" /label="yfjO gene" downshifts 824391 /Source="Nicolas_upshifts" /id="D402" /incds=0 /nref=198 /ntot=251 /MaxReadThrough="1.18186" /MaxDrop="5.19313" /score="11.8630961" /energy="-12.6" /TU="NA" /idTUdmin="U614" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 824685..824692 /Source="Nicolas_upshift_promotors" /id="U615" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2924 /SigmaFactorBS="tagatgtattttcataatttgtaaaattataTATTGACTtgc agttattacgtgTGAAATATTGATGATAGGAAtataaggaaagtatggcgtatatcat t" /listShort="S278, yfzA, S279" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 824708..824727 /Source="Nicolas_upshift_promotors" /id="U615" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2924 /SigmaFactorBS="tagatgtattttcataatttgtaaaattataTATTGACTtgc agttattacgtgTGAAATATTGATGATAGGAAtataaggaaagtatggcgtatatcat t" /listShort="S278, yfzA, S279" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 824714 /Source="Nicolas_upshifts" /id="U615" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2924 /SigmaFactorBS="tagatgtattttcataatttgtaaaattataTATTGACTtgc agttattacgtgTGAAATATTGATGATAGGAAtataaggaaagtatggcgtatatcat t" /listShort="S278, yfzA, S279" /GFF_Attribute="listLong" /label="upshifts" S_feature 824721..825004 /Source="Nicolas_S_feature" /locus_tag="new_875144_875427" /HighExp="M9-stat, T1.30H, T0.30H, T2.0H, LoTm, T3.0H, T3.30H, T1.0H, T2.30H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.69102300000000005" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S278" CDS 825005..825271 /gene="yfzA" /locus_tag="BSU_08029" /old_locus_tag="BSU08029" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097694.1" /db_xref="EnsemblGenomes-Gn:BSU08029" /db_xref="EnsemblGenomes-Tr:CAX52581" /db_xref="GOA:C0H3X6" /db_xref="InterPro:IPR025627" /db_xref="UniProtKB/Swiss-Prot:C0H3X6" /translation="MDKVYKRSWFQTFLAFLVSQLYFNFVELTGWGPKYREMNGFPAN IVELDFFQTYLSFYDNPWFNIITVFLGVFTIIQIITGITKDIRN*" /label="yfzA CDS" gene 825005..825271 /gene="yfzA" /locus_tag="BSU_08029" /old_locus_tag="BSU08029" /label="yfzA gene" promotor_-10 complement(825219..825238) /Source="Nicolas_upshift_promotors" /id="U616" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.936063936063936" /psig=1 /xcortree=2926 /SigmaFactorBS="taaataaggcatcagaagttattgctttaatttcgaatatcC TTTgttatccctgtaatTATTTGTATAATAGTGAAAActcccaagaaaacagtaataa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(825237) /Source="Nicolas_upshifts" /id="U616" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.936063936063936" /psig=1 /xcortree=2926 /SigmaFactorBS="taaataaggcatcagaagttattgctttaatttcgaatatcC TTTgttatccctgtaatTATTTGTATAATAGTGAAAActcccaagaaaacagtaataa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(825253..825256) /Source="Nicolas_upshift_promotors" /id="U616" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.936063936063936" /psig=1 /xcortree=2926 /SigmaFactorBS="taaataaggcatcagaagttattgctttaatttcgaatatcC TTTgttatccctgtaatTATTTGTATAATAGTGAAAActcccaagaaaacagtaataa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 825272..825753 /Source="Nicolas_S_feature" /locus_tag="new_875695_876176" /HighExp="G180, Paraq, H2O2, G135, Oxctl, G150, C30, LoTm, S8, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S279" promotor_-35 825724..825727 /Source="Nicolas_upshift_promotors" /id="U617" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.591408591408591" /psig=1 /xcortree=2598 /SigmaFactorBS="atcttcaataacagggcaattattttgcgTTGGtaatatgga gaactcaTATGATATTCTATTTAGGTTggaatcctttttatccaaaaagttcaaaagc a" /listShort="S280, dusC, S281, yfjM, yfjL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 825744..825763 /Source="Nicolas_upshift_promotors" /id="U617" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.591408591408591" /psig=1 /xcortree=2598 /SigmaFactorBS="atcttcaataacagggcaattattttgcgTTGGtaatatgga gaactcaTATGATATTCTATTTAGGTTggaatcctttttatccaaaaagttcaaaagc a" /listShort="S280, dusC, S281, yfjM, yfjL" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 825755..826002 /Source="Nicolas_S_feature" /locus_tag="new_876178_876425" /HighExp="H2O2, G180, Paraq, G150, G135, Oxctl, dia15, LBGstat, LBGexp, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S280" upshifts 825755 /Source="Nicolas_upshifts" /id="U617" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.591408591408591" /psig=1 /xcortree=2598 /SigmaFactorBS="atcttcaataacagggcaattattttgcgTTGGtaatatgga gaactcaTATGATATTCTATTTAGGTTggaatcctttttatccaaaaagttcaaaagc a" /listShort="S280, dusC, S281, yfjM, yfjL" /GFF_Attribute="listLong" /label="upshifts" CDS 826003..826980 /gene="dusC" /locus_tag="BSU_08030" /old_locus_tag="BSU08030" /EC_number="1.-.-.-" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11983710, 25902496; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA-dihydrouridine synthase 2" /protein_id="NP_388684.1" /db_xref="EnsemblGenomes-Gn:BSU08030" /db_xref="EnsemblGenomes-Tr:CAB12632" /db_xref="GOA:O31546" /db_xref="InterPro:IPR001269" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR018517" /db_xref="InterPro:IPR024036" /db_xref="InterPro:IPR035587" /db_xref="SubtiList:BG12910" /db_xref="UniProtKB/Swiss-Prot:O31546" /translation="MTENFWRELPRPFFVLAPMEDVTDVVFRHVVSEAGRPDVFFTEF TNSESYCHPDGKDSVRGRLTFTEDEQPIVAHIWGDKPENFRKMSIGMAELGFKGLDIN MGCPVPNVAGNGKGSGLICRPAVAAELIQAAKAGGLPVSVKTRLGYTDVDEWREWLTH ILKQDIANLSIHLRTRAEMSKVDAHWELIPEIKKLRDEVAPDTLLTINGDIPDRQTGL KLAEQYGVDGIMIGRGIFTNPFAFEKEPKEHSSKELLDLLRLHLDLHDEYSKEEARPY KPLPRFFKIYLRGFRGASELRNQCMNTKSTDEVRALLDDFERKYLDGIE*" /label="dusC CDS" gene 826003..826980 /gene="dusC" /locus_tag="BSU_08030" /old_locus_tag="BSU08030" /label="dusC gene" S_feature 826981..827073 /Source="Nicolas_S_feature" /locus_tag="new_877404_877496" /HighExp="G135, G180, Paraq, G150, H2O2, LBGexp, aero, dia0, Oxctl, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S281" downshifts 827030 /Source="Nicolas_upshifts" /id="D403" /incds=0 /nref=86 /ntot=218 /MaxReadThrough="3.30163" /MaxDrop="4.0519" /score="11.8630961" /energy="-12.6" /TU="U617" /idTUdmin="U618" /TUdmin="-1211" /isTUend="FALSE" /label="downshifts" promotor_-35 827114..827120 /Source="Nicolas_upshift_promotors" /id="U618" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.994005994005994" /psig="0.999000999001" /xcortree=3192 /SigmaFactorBS="gtacgcagcttttactcagcctgtcttttctctAATTTATtg taagaaaatAATGGTATATTTAGTGGAGAtatcatataaagggggagaggaaaatgaa a" /listShort="yfjM, yfjL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 827132..827151 /Source="Nicolas_upshift_promotors" /id="U618" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.994005994005994" /psig="0.999000999001" /xcortree=3192 /SigmaFactorBS="gtacgcagcttttactcagcctgtcttttctctAATTTATtg taagaaaatAATGGTATATTTAGTGGAGAtatcatataaagggggagaggaaaatgaa a" /listShort="yfjM, yfjL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 827141 /Source="Nicolas_upshifts" /id="U618" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.994005994005994" /psig="0.999000999001" /xcortree=3192 /SigmaFactorBS="gtacgcagcttttactcagcctgtcttttctctAATTTATtg taagaaaatAATGGTATATTTAGTGGAGAtatcatataaagggggagaggaaaatgaa a" /listShort="yfjM, yfjL" /GFF_Attribute="listLong" /label="upshifts" CDS 827176..827628 /gene="yfjM" /locus_tag="BSU_08040" /old_locus_tag="BSU08040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388685.1" /db_xref="EnsemblGenomes-Gn:BSU08040" /db_xref="EnsemblGenomes-Tr:CAB12633" /db_xref="SubtiList:BG12909" /db_xref="UniProtKB/Swiss-Prot:O31547" /translation="MKRLCIIPCGKKKIWDVQPDAGPVRAEDAYLSPFHQACERYAKT FFDEWVILSAKHGFLRPDDLVSGNYDVTFGTGHPEIMTADELRRQFHEKGFSDIEELV MLGGKKYRSVLNAVIGEHQHISWPLSSYKGIGYMLQALNRAVEEKHEL*" /label="yfjM CDS" gene 827176..827628 /gene="yfjM" /locus_tag="BSU_08040" /old_locus_tag="BSU08040" /label="yfjM gene" CDS 827658..828347 /gene="yfjL" /locus_tag="BSU_08050" /old_locus_tag="BSU08050" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388686.1" /db_xref="EnsemblGenomes-Gn:BSU08050" /db_xref="EnsemblGenomes-Tr:CAB12634" /db_xref="InterPro:IPR020523" /db_xref="SubtiList:BG11034" /db_xref="UniProtKB/Swiss-Prot:P40773" /translation="MKKLVFGLLAIVLFGCGLYIYHVWFGDPFSKNAAEQKLVSYVKQ TYPKKEIKITNGVYNAKTSEYVFEATSQSHRYPMCTKGFLHPKVTCDGIEEAYTESVA KHVNEEATKAIEADLKKAVPRFIKADAALSIENGQFTLDTKWNKKLAEKAPMSMTIQL DASGLSKTDAAKMAETVRKTLNEKGYTYSNGTIDCMQKDGDGGIGYVKYSIDFLSKAA IQSNDAEELGS*" /label="yfjL CDS" gene 827658..828347 /gene="yfjL" /locus_tag="BSU_08050" /old_locus_tag="BSU08050" /label="yfjL gene" downshifts 828352 /Source="Nicolas_upshifts" /id="D404" /incds=0 /nref=31 /ntot=205 /MaxReadThrough="0.02745" /MaxDrop="3.61164" /score="23.9796437" /energy="-9" /TU="NA" /idTUdmin="U617" /TUdmin=1 /isTUend="TRUE" /label="downshifts" misc_feature 828524..828542 /Source="Nicolas_upshift_promotors" /id="U619" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.878121878121878" /psig="0.878121878121878" /xcortree=351 /SigmaFactorBS="caaactgtctccaaagtgaagatgagaagactgattttacgg gctcaaaagacTGGCACACTTCTTGCATTTataatggtgaaccctaaatagaaggagg c" /listShort="acoA, acoB, acoC, acoL, acoR, sspH" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 828531 /Source="Nicolas_upshifts" /id="U619" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.878121878121878" /psig="0.878121878121878" /xcortree=351 /SigmaFactorBS="caaactgtctccaaagtgaagatgagaagactgattttacgg gctcaaaagacTGGCACACTTCTTGCATTTataatggtgaaccctaaatagaaggagg c" /listShort="acoA, acoB, acoC, acoL, acoR, sspH" /GFF_Attribute="listLong" /label="upshifts" CDS 828579..829580 /gene="acoA" /locus_tag="BSU_08060" /old_locus_tag="BSU08060" /EC_number="1.1.1.303" /EC_number="2.3.1.190" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10368162, 11274109, 22714279" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10368162, 11274109, 22714279; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetoin dehydrogenase E1 component (TPP-dependent alpha subunit)" /protein_id="NP_388687.1" /db_xref="EnsemblGenomes-Gn:BSU08060" /db_xref="EnsemblGenomes-Tr:CAB12635" /db_xref="GOA:O31404" /db_xref="InterPro:IPR001017" /db_xref="InterPro:IPR029061" /db_xref="SubtiList:BG12558" /db_xref="UniProtKB/Swiss-Prot:O31404" /translation="MKLLKREGLSLTEEKALWMYQKMLEIRGFEDKVHELFAQGVLPG FVHLYAGEEAVAVGVCAHLHDGDSITSTHRGHGHCIAKGCDLDGMMAEIFGKATGLCK GKGGSMHIADLDKGMLGANGIVGGGFTLACGSALTAKYKQTKNVSVCFFGDGANNQGT FHEGLNLAAVWNLPVVFVAENNGYGEATPFEYASACDSIADRAAAYNMPGVTVDGKDI LAVYQAAEEAIERARNGGGPSLIECMTYRNYGHFEGDAQTYKTKDERVEHLEEKDAIQ GFKNYLLKETDANKLSDIEQRVSESIEKAVSFSEDSPYPKDSELLTDVYVSYEKGGM* " /label="acoA CDS" gene 828579..829580 /gene="acoA" /locus_tag="BSU_08060" /old_locus_tag="BSU08060" /label="acoA gene" CDS 829584..830612 /gene="acoB" /locus_tag="BSU_08070" /old_locus_tag="BSU08070" /EC_number="1.1.1.303" /EC_number="2.3.1.190" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11274109, 10368162" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11274109, 10368162; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetoin dehydrogenase E1 component (TPP-dependent beta subunit)" /protein_id="NP_388688.1" /db_xref="EnsemblGenomes-Gn:BSU08070" /db_xref="EnsemblGenomes-Tr:CAB12636" /db_xref="GOA:O34591" /db_xref="InterPro:IPR005475" /db_xref="InterPro:IPR009014" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR033248" /db_xref="SubtiList:BG12559" /db_xref="UniProtKB/Swiss-Prot:O34591" /translation="MARVISMSDAINEAMKLAMRKDENVLLIGEDVAGGAAVDHLQDD EAWGGVLGVTKGLVQEFGRTRVLDTPISEAGYMGAAMAAASTGLRPIAELMFNDFIGT CFDQVINQGAKFRYMFGGKAQVPITVRTTYGAGFRAAAQHSQSLYGLFTSIPGLKTVV PSNPYDAKGLLLAAIEDNDPVFFFEDKTSYNMKGEVPEDYYTIPLGKADIKREGNDVT LFAVGKQVNTALEAAAQLSERGIEAEVLDPRSLSPLDEDAIFTSLEKTNRLIIIDEAN PRCSIATDIAALVADKGFDLLDAPIKRITAPHTPVPFSPVLEDQYLPTPDKIVSVTLE LLGEPALN*" /label="acoB CDS" gene 829584..830612 /gene="acoB" /locus_tag="BSU_08070" /old_locus_tag="BSU08070" /label="acoB gene" CDS 830626..831822 /gene="acoC" /locus_tag="BSU_08080" /old_locus_tag="BSU08080" /EC_number="2.3.1.12" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10368162, 11274109" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10368162, 11274109; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetoin dehydrogenase E2 component (dihydrolipoamide acetyltransferase)" /protein_id="NP_388689.1" /db_xref="EnsemblGenomes-Gn:BSU08080" /db_xref="EnsemblGenomes-Tr:CAB12637" /db_xref="GOA:O31550" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR001078" /db_xref="InterPro:IPR004167" /db_xref="InterPro:IPR011053" /db_xref="InterPro:IPR036625" /db_xref="SubtiList:BG12560" /db_xref="UniProtKB/Swiss-Prot:O31550" /translation="MAVKVVMPKLGMAMKQGEVSIWNKKVGDPVEKGESIASIQSEKI EMEIEAPEKGTLIDIKVKEGEEVPPGTAICYIGDANESVQEEAGAPVAEDNMPQAVQP VKQENKPAASKKDRMKISPVARKIAEKAGLDLKQLKGTGPGGRIVKDDVTKALAEQKK DQAKPVSEQKAQEIPVTGMRKVIAARMQESLANSAQLTITMKADITKLATLQKQLSPT AEERYGTKLTITHFVSRAAVLALQAHPVLNSFYQNERIITHPHVHLGMAVALENGLVV PVIRHAEKLSLIELAQSISENAKKAREGRAGSEELQGSTFSITNLGAFGVEHFTPILN PPETGILGIGASYDTPVYQGEEIVRSTILPLSLTFDHRACDGAPAAAFLKAMKTYLEE PAALIL*" /label="acoC CDS" gene 830626..831822 /gene="acoC" /locus_tag="BSU_08080" /old_locus_tag="BSU08080" /label="acoC gene" downshifts complement(830627) /Source="Nicolas_upshifts" /id="D405" /incds=0 /nref=8 /ntot=46 /MaxReadThrough="0.481579999999999" /MaxDrop="4.16582" /score="-0.0231058321" /energy="-9.9" /TU="NA" /idTUdmin="U623" /TUdmin=4796 /isTUend="FALSE" /label="downshifts" CDS 831843..833219 /gene="acoL" /locus_tag="BSU_08090" /old_locus_tag="BSU08090" /EC_number="1.8.1.4" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11274109, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11274109, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetoin dehydrogenase E3 component (dihydrolipoamide dehydrogenase)" /protein_id="NP_388690.1" /db_xref="EnsemblGenomes-Gn:BSU08090" /db_xref="EnsemblGenomes-Tr:CAB12638" /db_xref="GOA:O34324" /db_xref="InterPro:IPR001100" /db_xref="InterPro:IPR004099" /db_xref="InterPro:IPR006258" /db_xref="InterPro:IPR012999" /db_xref="InterPro:IPR016156" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG12561" /db_xref="UniProtKB/Swiss-Prot:O34324" /translation="MTLAIIGGGPAGYAAAVSAAQQGRNVLLIDKGKLGGTCLNEGCI PTKSLLESANVLDKIKHADSFGIELPAGAISVDWSKMQSRKQQVVSQLVQGVQYLMKK NQIQVVKGTASFLSERKLLIEGENGKEIREADQVLIASGSEPIELPFAPFDGEWILDS KDALSLSEIPSSLVIVGGGVIGCEYAGLFARLGSQVTIIETADRLIPAEDEDIARLFQ EKLEEDGVEVHTSSRLGRVDQTAKTAIWKSGQREFKTKADYVLVAIGRKPRLDGLQLE QAGVDFSPKGIPVNGHMQTNVPHIYACGDAIGGIQLAHAAFHEGIIAASHASGRDVKI NEKHVPRCIYTSPEIACIGMTERQARSIYGDVKIGEFSFSANGKALIKQQAEGKVKIM AEPEFGEIVGVSMIGPDVTELIGQAAAIMNGEMTADMAEHFIAAHPTLSETLHEALLS TIGLAVHA*" /label="acoL CDS" gene 831843..833219 /gene="acoL" /locus_tag="BSU_08090" /old_locus_tag="BSU08090" /label="acoL gene" downshifts 833213 /Source="Nicolas_upshifts" /id="D406" /incds=0 /nref=27 /ntot=56 /MaxReadThrough="5.75671" /MaxDrop="5.6153" /score="27.0133719" /energy="-14.7" /TU="U619" /idTUdmin="U619" /TUdmin="-2156" /isTUend="FALSE" /label="downshifts" promotor_-35 833266..833273 /Source="Nicolas_upshift_promotors" /id="U620" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.57942057942058" /psig=1 /xcortree=368 /SigmaFactorBS="ggcgcatggatataaggcgcctgcttttttatTGTTGAAAgc gctttattttTCCCCTACAATAGATGAAAAcggcgtgtaagggaggagcgatcaagga a" /listShort="acoR, sspH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 833286..833305 /Source="Nicolas_upshift_promotors" /id="U620" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.57942057942058" /psig=1 /xcortree=368 /SigmaFactorBS="ggcgcatggatataaggcgcctgcttttttatTGTTGAAAgc gctttattttTCCCCTACAATAGATGAAAAcggcgtgtaagggaggagcgatcaagga a" /listShort="acoR, sspH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 833294 /Source="Nicolas_upshifts" /id="U620" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.57942057942058" /psig=1 /xcortree=368 /SigmaFactorBS="ggcgcatggatataaggcgcctgcttttttatTGTTGAAAgc gctttattttTCCCCTACAATAGATGAAAAcggcgtgtaagggaggagcgatcaagga a" /listShort="acoR, sspH" /GFF_Attribute="listLong" /label="upshifts" CDS 833335..835152 /gene="acoR" /locus_tag="BSU_08100" /old_locus_tag="BSU08100" /experiment="publication(s) with functional evidences, PMID:11274109, 16944132" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11274109, 16944132; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (AcoR-acetoin)" /protein_id="NP_388691.1" /db_xref="EnsemblGenomes-Gn:BSU08100" /db_xref="EnsemblGenomes-Tr:CAB12639" /db_xref="GOA:O31551" /db_xref="InterPro:IPR002078" /db_xref="InterPro:IPR002197" /db_xref="InterPro:IPR003018" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR025944" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR029016" /db_xref="SubtiList:BG11790" /db_xref="UniProtKB/Swiss-Prot:O31551" /translation="MNSVPNDLQTWKRFVKDGVLDEARLRKRIAESWHRCKKAEVNPY LEKGPKVLQQTELDQQSKKHSFFLTTAKPYLEKLLPAIKEMEMMALLIDSDGVVLALD GHPRALYEAKRINFVEGACWTETAVGTNAIGTALHISEPVAIQGSEHYSIASHLWNCS AAPIHHEDGSLAGVIDISCPAAGAHPHMLGIATAIAYAAERELAAKSREKELELISRF GERAASSVPMVLCNTKQHIISASMPIRTSMPDWQGRHLYELKERGYSIENAVTIGDGG TCFYLSEQKKKKAFRFNGVIGQSGRSQAMLMHLERAAATDASVCLSGETGTGKEVAAR ALHENSERRHGPFVAVNCGAIPSDLIESELFGYAEGAFTGAKRNGYKGAFQKANQGTL FLDEIGEISHSMQVALLRVLQERKITPIGGTKEIPVDIRVIAATHCDLRELAENGKIR EDLFYRLHVYPIELPPLRDRTEDIPDLFEYYKQKNHWPGDLPSDFCNVLKQWKWPGNI RELFNVFERLSIRFPDGRLRDESLPALLEAAGLPASSAEKKPAAAGVLTFREQIQKDM MIKALESAKGNVSQAAKISGIPRSTFYKRLKKFNLSAES*" /label="acoR CDS" gene 833335..835152 /gene="acoR" /locus_tag="BSU_08100" /old_locus_tag="BSU08100" /label="acoR gene" promotor_-35 835153..835159 /Source="Nicolas_upshift_promotors" /id="U621" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=916 /SigmaFactorBS="tacaaacgcctgaaaaaattcaacttgtccgctgaatcataa AGCATACttccttcaggaaatGGAAACGTTATGtattgaaggagggtgttacgatgaa t" /listShort="sspH" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 835171 /Source="Nicolas_upshifts" /id="U621" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=916 /SigmaFactorBS="tacaaacgcctgaaaaaattcaacttgtccgctgaatcataa AGCATACttccttcaggaaatGGAAACGTTATGtattgaaggagggtgttacgatgaa t" /listShort="sspH" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 835174..835185 /Source="Nicolas_upshift_promotors" /id="U621" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=916 /SigmaFactorBS="tacaaacgcctgaaaaaattcaacttgtccgctgaatcataa AGCATACttccttcaggaaatGGAAACGTTATGtattgaaggagggtgttacgatgaa t" /listShort="sspH" /GFF_Attribute="listLong" /label="promotor_-10" CDS 835206..835385 /gene="sspH" /locus_tag="BSU_08110" /old_locus_tag="BSU08110" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10333516" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10333516; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="NP_388692.1" /db_xref="EnsemblGenomes-Gn:BSU08110" /db_xref="EnsemblGenomes-Tr:CAB12640" /db_xref="GOA:O31552" /db_xref="InterPro:IPR012610" /db_xref="SubtiList:BG12917" /db_xref="UniProtKB/Swiss-Prot:O31552" /translation="MNIQRAKEIVESPDMKKVTYNGVPIYIQHVNEETGTARIYPLDE PQEEHEVQLNSLKED*" /label="sspH CDS" gene 835206..835385 /gene="sspH" /locus_tag="BSU_08110" /old_locus_tag="BSU08110" /label="sspH gene" downshifts 835369 /Source="Nicolas_upshifts" /id="D407" /incds=0 /nref=96 /ntot=181 /MaxReadThrough="1.9176" /MaxDrop="6.06509" /score="5.08326573" /energy="-12" /TU="NA" /idTUdmin="U619" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(835421..835750) /gene="yfjF" /locus_tag="BSU_08120" /old_locus_tag="BSU08120" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="NP_388693.1" /db_xref="EnsemblGenomes-Gn:BSU08120" /db_xref="EnsemblGenomes-Tr:CAB12641" /db_xref="GOA:O31553" /db_xref="InterPro:IPR003844" /db_xref="SubtiList:BG12908" /db_xref="UniProtKB/Swiss-Prot:O31553" /translation="MMLITILLFLAAGLAEIGGGYLVWLWLREAKPAGYGIAGALILI VYGILPTFQSFPSFGRVYAAYGGVFIVLAVLWGWLVDRKTPDLYDWIGAFICLIGVCV ILFAPRG*" /label="yfjF CDS" gene complement(835421..835750) /gene="yfjF" /locus_tag="BSU_08120" /old_locus_tag="BSU08120" /label="yfjF gene" downshifts complement(835435) /Source="Nicolas_upshifts" /id="D408" /incds=0 /nref=96 /ntot=245 /MaxReadThrough="2.05328" /MaxDrop="6.2642" /score="34.1179702" /energy="-15.8" /TU="NA" /idTUdmin="U623" /TUdmin="-12" /isTUend="TRUE" /label="downshifts" CDS complement(835800..836258) /gene="yfjE" /locus_tag="BSU_08130" /old_locus_tag="BSU08130" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388694.1" /db_xref="EnsemblGenomes-Gn:BSU08130" /db_xref="EnsemblGenomes-Tr:CAB12642" /db_xref="GOA:O31554" /db_xref="InterPro:IPR035324" /db_xref="SubtiList:BG12907" /db_xref="UniProtKB/Swiss-Prot:O31554" /translation="MSEALTFESKYALLYLGGGLLAMIYGLITFFMAFPAFTSRGNVI FTIKTGPSGEIFLRKRSVLFSEVKRLYMGRHQYSLKGIFFEDIIIEKTDGKIVRIPTW NIITNPLFFEAVERYILPHLNEEAQNNWISQFTEVQRKAYLKEFENHPKL*" /label="yfjE CDS" gene complement(835800..836258) /gene="yfjE" /locus_tag="BSU_08130" /old_locus_tag="BSU08130" /label="yfjE gene" S_feature complement(836259..836351) /Source="Nicolas_S_feature" /locus_tag="new_886682_886774_c" /HighExp="BI, BC, S2, Sw, HiOs, HiTm, S5, ferm, S4, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S282" CDS complement(836352..836909) /gene="yfjD" /locus_tag="BSU_08140" /old_locus_tag="BSU08140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388695.1" /db_xref="EnsemblGenomes-Gn:BSU08140" /db_xref="EnsemblGenomes-Tr:CAB12643" /db_xref="GOA:O31555" /db_xref="InterPro:IPR035324" /db_xref="SubtiList:BG12906" /db_xref="UniProtKB/Swiss-Prot:O31555" /translation="MKNQEIIEVKSKMFLRIWAFVGSAGMGLACLWLFYMGITFQTKY YLLAIPAGFLFTLFCLYLFIIFFPAFTPRGNTIFRIKTGKNGEVFTDKVSVTFTDIKK IEMSRHKFSLKGIFQEDILIQTVDQKTIRIPTWNIIPNPLFFEAVERYILPHLNEEAK SNWIGQFTDIQRSAYLKEFENHPKL*" /label="yfjD CDS" gene complement(836352..836909) /gene="yfjD" /locus_tag="BSU_08140" /old_locus_tag="BSU08140" /label="yfjD gene" promotor_-35 836775..836780 /Source="Nicolas_upshift_promotors" /id="U622" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1171 /SigmaFactorBS="tataaacaaaacaaggtgaacagaaagccagcaggaatggct aatagGTAATAtttcgtttgaaacgTAATACCCATATAAAAGAGccacaaacatgcta a" /listShort="S283" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 836788 /Source="Nicolas_upshifts" /id="U622" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1171 /SigmaFactorBS="tataaacaaaacaaggtgaacagaaagccagcaggaatggct aatagGTAATAtttcgtttgaaacgTAATACCCATATAAAAGAGccacaaacatgcta a" /listShort="S283" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 836795..836813 /Source="Nicolas_upshift_promotors" /id="U622" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1171 /SigmaFactorBS="tataaacaaaacaaggtgaacagaaagccagcaggaatggct aatagGTAATAtttcgtttgaaacgTAATACCCATATAAAAGAGccacaaacatgcta a" /listShort="S283" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 836799..837386 /Source="Nicolas_S_feature" /locus_tag="new_887222_887809" /HighExp="S4, S5, S6, S3, S8, S7, LoTm, T5.0H, T4.0H, Pyr" /AntisenseName="yfjC" /AntisenseCor="9.3643586039105595E-2" /AntisenseRegPval="-0.9" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S283" CDS complement(836941..837708) /gene="yfjC" /locus_tag="BSU_08150" /old_locus_tag="BSU08150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 14563871" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388696.1" /db_xref="EnsemblGenomes-Gn:BSU08150" /db_xref="EnsemblGenomes-Tr:CAB12644" /db_xref="SubtiList:BG12905" /db_xref="UniProtKB/Swiss-Prot:O31556" /translation="MKQFTISIEELLFCFYSEGFFEQGMALKQAYFPEIEDEQLGALF EAACRSLLAKDAAEYRNHQYRLKDEYCPFIHVLNDADYTVKLSKFNGQGAEQNVSCHV SKFGTYSHELLFDEQVHRITKMESSEGLLAKTDEFLHIIDTEDKRESIVTLTSNEFEK LLEGASDNPSYLKEFLEKHDHQEDVTRFANDLALRKGKMDTLMRLAYGKDNTPEVADM AFVLPGAHHTWLVTGITQNEFSILPAHKDVVNQIISK*" /label="yfjC CDS" gene complement(836941..837708) /gene="yfjC" /locus_tag="BSU_08150" /old_locus_tag="BSU08150" /label="yfjC gene" CDS complement(837720..838943) /gene="yfjB" /locus_tag="BSU_08160" /old_locus_tag="BSU08160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative phage protein" /protein_id="NP_388697.1" /db_xref="EnsemblGenomes-Gn:BSU08160" /db_xref="EnsemblGenomes-Tr:CAB12645" /db_xref="SubtiList:BG12904" /db_xref="UniProtKB/Swiss-Prot:O31557" /translation="MSGNIAVDPDKLEQLANDVVTELTDMENKYKDLHVELGQMILQC DPRYSSCFSGVGDAWSSGKALVTKLSDNEIFIRKTGDKFVEQDDILRKLYNAYDKYGT MTSLTALMLTQGKYYGLGLTKFVKQPSGLHTAQHSKLLLDISRAVDSSRYQKAARVLL NPKYLLKKTNRPFSDLVHKKFTKYFPQDTVDFSNSVRSYTKGFLNEAGVRSTLKDVGK TGLRFAKGNAITATLITGATETFGAGVKIAENYAKYQDKPEVLKRENAKAVGNAVNNT IFVAGGATAGAVIGGAIGSFAGPVGTVLLGAAGSYIGGVVGEQIAKYTAGFAEKAALK LKEPIHAVVDTAKKGLESAGKVVKSVNDGIDAANKSIHKGIDSAKKGMEKAKKTADSL IHGATHFLKGKFSFG*" /label="yfjB CDS" gene complement(837720..838943) /gene="yfjB" /locus_tag="BSU_08160" /old_locus_tag="BSU08160" /label="yfjB gene" CDS complement(838949..839263) /gene="yfjA" /locus_tag="BSU_08170" /old_locus_tag="BSU08170" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388698.1" /db_xref="EnsemblGenomes-Gn:BSU08170" /db_xref="EnsemblGenomes-Tr:CAB12646" /db_xref="InterPro:IPR010310" /db_xref="InterPro:IPR036689" /db_xref="SubtiList:BG12903" /db_xref="UniProtKB/Swiss-Prot:O31558" /translation="MDSYKVIELANKYSAAAEEVRSSKMLLESRLSALGDAWQGKARD SFDQDFEETKAAYDQFEQELLETSQELKAAAVKIEERKAEIARMEELERKAREERHKL GR*" /label="yfjA CDS" gene complement(838949..839263) /gene="yfjA" /locus_tag="BSU_08170" /old_locus_tag="BSU08170" /label="yfjA gene" promotor_-10 complement(839311..839330) /Source="Nicolas_upshift_promotors" /id="U623" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.852147852147852" /psig="0.992007992007992" /xcortree=2761 /SigmaFactorBS="cgcccttccaattcttatgaaaaggttcttttgtacGATTcg gatacatgccgaATTATTTATAATCATTTATAtaaaacatccaattgtgcgtgaattt a" /listShort="yfjA, yfjB, yfjC, yfjD, S282, yfjE, yfjF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(839324) /Source="Nicolas_upshifts" /id="U623" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.852147852147852" /psig="0.992007992007992" /xcortree=2761 /SigmaFactorBS="cgcccttccaattcttatgaaaaggttcttttgtacGATTcg gatacatgccgaATTATTTATAATCATTTATAtaaaacatccaattgtgcgtgaattt a" /listShort="yfjA, yfjB, yfjC, yfjD, S282, yfjE, yfjF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(839345..839348) /Source="Nicolas_upshift_promotors" /id="U623" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.852147852147852" /psig="0.992007992007992" /xcortree=2761 /SigmaFactorBS="cgcccttccaattcttatgaaaaggttcttttgtacGATTcg gatacatgccgaATTATTTATAATCATTTATAtaaaacatccaattgtgcgtgaattt a" /listShort="yfjA, yfjB, yfjC, yfjD, S282, yfjE, yfjF" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 839555..839574 /Source="Nicolas_upshift_promotors" /id="U624" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.258741258741259" /psig="0.684315684315684" /xcortree=342 /SigmaFactorBS="cactaaagttgatcaaatgacctaagtgcgccaaacgtgtta cgggacgagctatctCATGGTATAAATGGAATTGTaaacgttatcaaggaggtcgtca t" /listShort="malA, malR, malP, malQ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 839558 /Source="Nicolas_upshifts" /id="U624" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.258741258741259" /psig="0.684315684315684" /xcortree=342 /SigmaFactorBS="cactaaagttgatcaaatgacctaagtgcgccaaacgtgtta cgggacgagctatctCATGGTATAAATGGAATTGTaaacgttatcaaggaggtcgtca t" /listShort="malA, malR, malP, malQ" /GFF_Attribute="listLong" /label="upshifts" CDS 839599..840948 /gene="malA" /locus_tag="BSU_08180" /old_locus_tag="BSU08180" /EC_number="3.2.1.122" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9765262, 10329789, 11489864, 15341727, 15670594, 16707683, 17676871, 20698522" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9765262, 10329789, 11489864, 15341727, 15670594, 16707683, 17676871, 20698522; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="6-phospho-alpha-glucosidase" /protein_id="NP_388699.1" /db_xref="EnsemblGenomes-Gn:BSU08180" /db_xref="EnsemblGenomes-Tr:CAB12647" /db_xref="GOA:P54716" /db_xref="InterPro:IPR001088" /db_xref="InterPro:IPR015955" /db_xref="InterPro:IPR019802" /db_xref="InterPro:IPR022616" /db_xref="InterPro:IPR036291" /db_xref="PDB:1U8X" /db_xref="SubtiList:BG11839" /db_xref="UniProtKB/Swiss-Prot:P54716" /translation="MKKKSFSIVIAGGGSTFTPGIVLMLLDHLEEFPIRKLKLYDNDK ERQDRIAGACDVFIREKAPDIEFAATTDPEEAFTDVDFVMAHIRVGKYAMRALDEQIP LKYGVVGQETCGPGGIAYGMRSIGGVLEILDYMEKYSPDAWMLNYSNPAAIVAEATRR LRPNSKILNICDMPVGIEDRMAQILGLSSRKEMKVRYYGLNHFGWWTSIQDQEGNDLM PKLKEHVSQYGYIPKTEAEAVEASWNDTFAKARDVQAADPDTLPNTYLQYYLFPDDMV KKSNPNHTRANEVMEGREAFIFSQCDMITREQSSENSEIKIDDHASYIVDLARAIAYN TGERMLLIVENNGAIANFDPTAMVEVPCIVGSNGPEPITVGTIPQFQKGLMEQQVSVE KLTVEAWAEKSFQKLWQALILSKTVPNARVARLILEDLVEANKDFWPELDQSPTRIS* " /label="malA CDS" gene 839599..840948 /gene="malA" /locus_tag="BSU_08180" /old_locus_tag="BSU08180" /label="malA gene" misc_feature 840977..840996 /Source="Nicolas_upshift_promotors" /id="U625" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=3083 /SigmaFactorBS="cttgatcaaagcccaacccgcatatcataaatgaaattcccc cattttcgaatctgtaATTGTATATAATAGAAAGAAaatggggggatctgatatgcag c" /listShort="malR, malP" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 840979 /Source="Nicolas_upshifts" /id="U625" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=3083 /SigmaFactorBS="cttgatcaaagcccaacccgcatatcataaatgaaattcccc cattttcgaatctgtaATTGTATATAATAGAAAGAAaatggggggatctgatatgcag c" /listShort="malR, malP" /GFF_Attribute="listLong" /label="upshifts" CDS 841013..841777 /gene="malR" /locus_tag="BSU_08190" /old_locus_tag="BSU08190" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11489864, 16707683, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11489864, 16707683, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional activator of the Mal operon" /protein_id="NP_388700.1" /db_xref="EnsemblGenomes-Gn:BSU08190" /db_xref="EnsemblGenomes-Tr:CAB12648" /db_xref="GOA:P54717" /db_xref="InterPro:IPR000281" /db_xref="InterPro:IPR001347" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR035472" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11847" /db_xref="UniProtKB/Swiss-Prot:P54717" /translation="MQLEELINQHYSKLNDNDFHILKYILNHKHTCYHLGIDALAKAC SVSRSSILRLAQKLGFSGYSEFRVFLKWEDQPEEGESMSFEKLLDDIEANLKFLRTKD MTDMCQLIDAADRIFVYGSGNAQKICARDLQRMFIPRHRYLILIEDTNEFNLMRDDFK VNDLFIIISLSGETPELIPQARMLSAKGIPFISITNLKNNVLAQLTPHNLYATSKPVT LSDRTEIVAFAPFFLVGEALFRAYVDYKEAEKNDNE*" /label="malR CDS" gene 841013..841777 /gene="malR" /locus_tag="BSU_08190" /old_locus_tag="BSU08190" /label="malR gene" promotor_-10 complement(841157..841171) /Source="Nicolas_upshift_promotors" /id="U626" /multdbtbs="-" /comp="M9" /sig="Sig-" /pcomp="0.454545454545455" /psig="0.454545454545455" /xcortree=655 /SigmaFactorBS="cttcttccggctgatcttcccactttaaaaagacgcgaaatt cactgtaaccgcTGAAACCgagcttttgggcaagCCGTAAAATTGAGGAacgcgatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(841187..841193) /Source="Nicolas_upshift_promotors" /id="U626" /multdbtbs="-" /comp="M9" /sig="Sig-" /pcomp="0.454545454545455" /psig="0.454545454545455" /xcortree=655 /SigmaFactorBS="cttcttccggctgatcttcccactttaaaaagacgcgaaatt cactgtaaccgcTGAAACCgagcttttgggcaagCCGTAAAATTGAGGAacgcgatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(841187) /Source="Nicolas_upshifts" /id="U626" /multdbtbs="-" /comp="M9" /sig="Sig-" /pcomp="0.454545454545455" /psig="0.454545454545455" /xcortree=655 /SigmaFactorBS="cttcttccggctgatcttcccactttaaaaagacgcgaaatt cactgtaaccgcTGAAACCgagcttttgggcaagCCGTAAAATTGAGGAacgcgatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 841792..843375 /gene="malP" /locus_tag="BSU_08200" /old_locus_tag="BSU08200" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16707683, 16850406, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16707683, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) maltose-specificenzyme IICB component" /protein_id="NP_388701.1" /db_xref="EnsemblGenomes-Gn:BSU08200" /db_xref="EnsemblGenomes-Tr:CAB12649" /db_xref="GOA:P54715" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR004719" /db_xref="InterPro:IPR010975" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG11848" /db_xref="UniProtKB/Swiss-Prot:P54715" /translation="MMQKIQRFGSAMFVPVLLFAFAGIIVGISTLFKNKTLMGPLADP DGFWYQCWYIIEQGGWTVFNQMPLLFAIGIPVALAKKAQARACLEALTVYLTFNYFVS AILTVWGGAFGVDMNQEVGGTSGLTMIAGIKTLDTNIIGAIFISSIVVFLHNRYFDKK LPDFLGIFQGSTYIVMISFFIMIPIALAVSYIWPMVQSGIGSLQSFLVASGAVGVWIY TFLERILIPTGLHHFIYTPFIYGPAVAEGGIVTYWAQHLGEYSQSAKPLKELFPQGGF ALHGNSKIFGIPGIALAFYVTAKKEKKKLVAGLLIPVTLTAIVAGITEPIEFTFLFIS PFLFAVHAVLAATMSTVMYMAGVVGNMGGGLIEAVTLNWIPLFGSHGMTYVYQILIGL SFTAIYFFVFRFLILKFNIATPGREKDEQQETKLYSKKEYRERKNKDETASAAETADD TAFLYIEALGGKDNITEVTNCATRLRVSVKDETKVEPDSVFRALGAHGVVRNGKAFQV IIGLSVPQMRERVEKILNQ*" /label="malP CDS" gene 841792..843375 /gene="malP" /locus_tag="BSU_08200" /old_locus_tag="BSU08200" /label="malP gene" downshifts 843355 /Source="Nicolas_upshifts" /id="D409" /incds=0 /nref=23 /ntot=46 /MaxReadThrough="3.26652" /MaxDrop="4.69656" /score="8.65399085" /energy="-10.9" /TU="U624" /idTUdmin="U625" /TUdmin=836 /isTUend="FALSE" /label="downshifts" promotor_-35 843404..843411 /Source="Nicolas_upshift_promotors" /id="U627" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2032 /SigmaFactorBS="aaagactgccctccttttcgggagggttttCGTTTGCCgtca aaaagaccgcCATAGTAAAGTAAAGAAAGAgacaatcgagtaaaaaggggtttggagg c" /listShort="malQ, yfiC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 843426..843445 /Source="Nicolas_upshift_promotors" /id="U627" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2032 /SigmaFactorBS="aaagactgccctccttttcgggagggttttCGTTTGCCgtca aaaagaccgcCATAGTAAAGTAAAGAAAGAgacaatcgagtaaaaaggggtttggagg c" /listShort="malQ, yfiC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 843434 /Source="Nicolas_upshifts" /id="U627" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2032 /SigmaFactorBS="aaagactgccctccttttcgggagggttttCGTTTGCCgtca aaaagaccgcCATAGTAAAGTAAAGAAAGAgacaatcgagtaaaaaggggtttggagg c" /listShort="malQ, yfiC" /GFF_Attribute="listLong" /label="upshifts" CDS 843481..845202 /gene="yfiB" /locus_tag="BSU_08210" /old_locus_tag="BSU08210" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16707683; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative xenobiotic ABC transporter subunit (ATP-binding protein)" /protein_id="NP_388702.1" /db_xref="EnsemblGenomes-Gn:BSU08210" /db_xref="EnsemblGenomes-Tr:CAB12650" /db_xref="GOA:P54718" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG11849" /db_xref="UniProtKB/Swiss-Prot:P54718" /translation="MQKALSFLKPYSLLAGIALILMLTELAVELMQPLLIAKIIDDGI LKQDLRHVWIWGTVMIGLTVLSFAAGMLNSFYAAHVSQSFSYDTRKGLFQKIQSFSYS TFGQFSSSSYITRLTNDVTQVQNMIFMSLRFMLRAPLMIAGGIVLSLAVNVKLGFFLL VTIPILILFLLWVLRKGGALFRSVQKRLDQVNTIMQENLIAIKLIKALLRGSHEVKRF IKANTRLMEKTVSAFQLVEFTMPVLMLLMNLCILLILWAGSYSITSGSTQVGDVVAII NYATRITGALSMFPFLIMIFTRAKASGDRIGEVLETEGDEREEGTISDRLSGRIEFQH VSFRYPEMDREALRNVSFSAKPRETIAILGATGSGKSTLFQLIPRLYQPDSGRIYIDE KPVQDIPAEGLRRQIGYVPQEVLLFSGTIKENIAWGKENASLDEIMDAAKLAQIHETI LKLPNGYDTVLGQRGVNLSGGQKQRISIARALIRKPAILLLDDSTSALDLQTEAKLLE AISTYHCTTLIITQKITTAMKADQILLLEDGELIEKGTHSELLSESQLYKRIYESQFG REGSESC*" /label="yfiB CDS" gene 843481..845202 /gene="yfiB" /locus_tag="BSU_08210" /old_locus_tag="BSU08210" /label="yfiB gene" CDS 845196..847010 /gene="yfiC" /locus_tag="BSU_08220" /old_locus_tag="BSU08220" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_388703.1" /db_xref="EnsemblGenomes-Gn:BSU08220" /db_xref="EnsemblGenomes-Tr:CAB12651" /db_xref="GOA:P54719" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG11850" /db_xref="UniProtKB/Swiss-Prot:P54719" /translation="MLKDIRKPFQYPKLPIDKKEGAKKRAKAKDTKGTLRRIWSYLAE RKGLLILVMLMVVISAIFGLLGPFVIGKAIDHFIVGKTVSGLIPVLLLLLAIYIIQSL SLWFQNYWMITISQGTVFRMRSELFTHLHELPIPFFDKQRHGELMSRVTNDIENVSST LNTSVIQILSSVITFVGTIAVMLYMSPLLTLITLTIIPVMAASLKWITNRTGKLFKEQ QKNLGDLNGYIEESVSGAKVIKAYSREKQITAEFLEKNAALKTSGFWAQTISGFIPKV MNSLNNLSFTMIAAIGGLFALKGWISIGSIVVFAEYSRQFTRPLNDLANQFNTMLSAI AGAERVFDVLDEKEEREDEKNAVHQPIQTGSIEFRDVSFGYDKGQQTLKHLQFTVPAG QSIAFVGPTGAGKTTVTNLLARFYEPNDGKILIDGTDIKTLTRASLRKNMGFVLQDSF LFQGTIRENIRYGRLDASDQEVEAAAKTANAHSFIERLPKGYDTVLTQNGSGISQGQK QLISIARAVLADPVLLILDEATSNIDTVTEVNIQEALARLMEGRTSVIIAHRLNTIQR ADQIVVLKNGEMIEKGSHDELIRQKGFYSDLYESQFEK*" /label="yfiC CDS" gene 845196..847010 /gene="yfiC" /locus_tag="BSU_08220" /old_locus_tag="BSU08220" /label="yfiC gene" downshifts 846985 /Source="Nicolas_upshifts" /id="D410" /incds=0 /nref=103 /ntot=190 /MaxReadThrough="2.4559" /MaxDrop="5.61906" /score="24.4395842" /energy="-11" /TU="NA" /idTUdmin="U627" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 847092..847099 /Source="Nicolas_upshift_promotors" /id="U628" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.75024975024975" /psig=1 /xcortree=1845 /SigmaFactorBS="cttttatttcattttcgtaaaatgtaacaaaattaCTTGACG TaaacaagttatgtATATATACTAGCTTACATTAagtaagtgataacatttatcaagg a" /listShort="catD, catE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 847113..847132 /Source="Nicolas_upshift_promotors" /id="U628" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.75024975024975" /psig=1 /xcortree=1845 /SigmaFactorBS="cttttatttcattttcgtaaaatgtaacaaaattaCTTGACG TaaacaagttatgtATATATACTAGCTTACATTAagtaagtgataacatttatcaagg a" /listShort="catD, catE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 847117 /Source="Nicolas_upshifts" /id="U628" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.75024975024975" /psig=1 /xcortree=1845 /SigmaFactorBS="cttttatttcattttcgtaaaatgtaacaaaattaCTTGACG TaaacaagttatgtATATATACTAGCTTACATTAagtaagtgataacatttatcaagg a" /listShort="catD, catE" /GFF_Attribute="listLong" /label="upshifts" CDS 847165..847569 /gene="catD" /locus_tag="BSU_08230" /old_locus_tag="BSU08230" /EC_number="1.13.11.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15849754, 16872404, 16850406, 17407181, 20639328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16872404, 16850406, 17407181, 20639328; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="catechol-2,3-dioxygenase membrane subunit" /protein_id="NP_388704.1" /db_xref="EnsemblGenomes-Gn:BSU08230" /db_xref="EnsemblGenomes-Tr:CAB12652" /db_xref="GOA:P54720" /db_xref="InterPro:IPR032808" /db_xref="SubtiList:BG11851" /db_xref="UniProtKB/Swiss-Prot:P54720" /translation="MNKSFEIGTLLLRVITGIIFFVHGLSKFQGMEGTIQFFGSIGLP SFMAYVIAAIELIGGVLVFFGLATRIVGVLFALTLIGAIITVKLKAPFMGNAEFDYLL LLTSIHLALTGSRFLALDPFVFKGKKNGNVSA*" /label="catD CDS" gene 847165..847569 /gene="catD" /locus_tag="BSU_08230" /old_locus_tag="BSU08230" /label="catD gene" CDS 847587..848444 /gene="catE" /locus_tag="BSU_08240" /old_locus_tag="BSU08240" /EC_number="1.13.11.2" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:17407181, 16872404" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17407181, 16872404; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="catechol-2,3-dioxygenase subunit" /protein_id="NP_388705.2" /db_xref="EnsemblGenomes-Gn:BSU08240" /db_xref="EnsemblGenomes-Tr:CAB12653" /db_xref="GOA:P54721" /db_xref="InterPro:IPR000486" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG11852" /db_xref="UniProtKB/Swiss-Prot:P54721" /translation="MTSIHEDTHIGYAKLTIRSLERSLQFYCNVIGFQVLKKTDRQAE LTADGKRVLLILEENPSAVVLPERSVTGLYHFAILLPDRKELGIALARLIEHGIAIGH GDHAVSEALYLSDPDGNGIEMYADRPRSTWQRDREGNYVMTTTAVDIEGLLEEAGDER KTSLPNDTIIGHIHLHVSDLKEAKAFYTDVLGFDIVGNYAGMSALFVSAGGYHHHIGL NIWAGRNAPPKPTNASGLDYYTVVLPHQEELDLVANRVKHAGYSIEETENSFRVKDPV SGAYITFVI*" /label="catE CDS" gene 847587..848444 /gene="catE" /locus_tag="BSU_08240" /old_locus_tag="BSU08240" /label="catE gene" downshifts 848431 /Source="Nicolas_upshifts" /id="D411" /incds=0 /nref=4 /ntot=21 /MaxReadThrough="0.66359" /MaxDrop="3.74886" /score="50.8573531" /energy="-19.7" /TU="NA" /idTUdmin="U628" /TUdmin=16 /isTUend="TRUE" /label="downshifts" CDS 848538..849482 /gene="yfiF" /locus_tag="BSU_08250" /old_locus_tag="BSU08250" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10704478; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (AraC/XylS family; cupin family)" /protein_id="NP_388706.1" /db_xref="EnsemblGenomes-Gn:BSU08250" /db_xref="EnsemblGenomes-Tr:CAB12654" /db_xref="GOA:P54722" /db_xref="InterPro:IPR003313" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR018060" /db_xref="InterPro:IPR018062" /db_xref="SubtiList:BG11853" /db_xref="UniProtKB/Swiss-Prot:P54722" /translation="MELNHLVTGKIALNQYVHRLEQKDVSFYVHYWGAMTNHYNTLLH KHSFYEICYVVRGEGYYLEGDRTYPLREQTIFLSKPEHLHQIKSETGLFLFYVAFELS EDQSSAEWIKVMEEVKQSPFITMQLKDGEPPGLLWKTLMLQAAQPVNAFDKEILSHLS HALILSLIQTFLPYAQRPKQKQPIHTSSALLTEVKLHIKDNLSQPLKLTDVASHFHIS GRHLSRLFAAELGVSYSEFVQNEKINKAAELLKSTNLSIKEIAEEIGFSVHYFTRVFS AKIGSSPGLFRSLYKDSKMTAFQINKPFQKIEQAKPHE*" /label="yfiF CDS" gene 848538..849482 /gene="yfiF" /locus_tag="BSU_08250" /old_locus_tag="BSU08250" /label="yfiF gene" downshifts complement(849349) /Source="Nicolas_upshifts" /id="D412" /incds=1 /nref=1 /ntot=2 /MaxReadThrough="-0.20031" /MaxDrop="3.51831" /score="-4.19869956" /energy="-9.5" /TU="NA" /idTUdmin="U632" /TUdmin=9372 /isTUend="FALSE" /label="downshifts" promotor_no_box complement(849397..849497) /Source="Nicolas_upshift_promotors" /id="U629" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.533466533466533" /psig="0.034965034965035" /xcortree=1481 /SigmaFactorBS="tcatttcaggacatcttattcgtgcggcttggcctgttcgat tttttgaaaaggtttattgatttgaaatgcggtcatttttgagtctttataaagggag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(849437) /Source="Nicolas_upshifts" /id="U629" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.533466533466533" /psig="0.034965034965035" /xcortree=1481 /SigmaFactorBS="tcatttcaggacatcttattcgtgcggcttggcctgttcgat tttttgaaaaggtttattgatttgaaatgcggtcatttttgagtctttataaagggag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 849657..851105 /gene="yfiG" /locus_tag="BSU_08260" /old_locus_tag="BSU08260" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sugar/proton transporter" /protein_id="NP_388707.1" /db_xref="EnsemblGenomes-Gn:BSU08260" /db_xref="EnsemblGenomes-Tr:CAB12655" /db_xref="GOA:P54723" /db_xref="InterPro:IPR003663" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11854" /db_xref="UniProtKB/Swiss-Prot:P54723" /translation="MSTKKKEAVIGKESLAHKGLLRTITLVSTFGGLLFGYDTGVING ALPFMATAGQLNLTPVTEGLVASSLLLGAAFGAMFGGRLSDRHGRRKTILYLALLFIA ATLGCTFSPNASVMIAFRFLLGLAVGCASVTVPTFLAEISPAERRGRIVTQNELMIVI GQLLAYTFNAIIGSTMGESANVWRYMLVIATLPAVVLWFGMLIVPESPRWLAAKGRMG DALRVLRQIREDSQAQQEIKEIKHAIEGTAKKAGFHDFQEPWIRRILFIGIGIAIVQQ ITGVNSIMYYGTEILREAGFQTEAALIGNIANGVISVIAVIFGIWLLGKVRRRPMLII GQIGTMTALLLIGILSIVLEGTPALPYVVLSLTILFLAFQQTAISTVTWLMLSEIFPM HVRGLGMGISTFCLWTANFLIGFTFPILLNHIGMSATFFIFVAMNILAILFVKKYVPE TKGRSLEQLEHSFRQYGRRADQEIQNQTTHLS*" /label="yfiG CDS" gene 849657..851105 /gene="yfiG" /locus_tag="BSU_08260" /old_locus_tag="BSU08260" /label="yfiG gene" CDS 851132..852073 /gene="yfiH" /locus_tag="BSU_08270" /old_locus_tag="BSU08270" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sugar-phosphate epimerase/isomerase" /protein_id="NP_388708.1" /db_xref="EnsemblGenomes-Gn:BSU08270" /db_xref="EnsemblGenomes-Tr:CAB12656" /db_xref="InterPro:IPR011418" /db_xref="InterPro:IPR013022" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG11855" /db_xref="UniProtKB/Swiss-Prot:P54724" /translation="MKLSYVTDSLGHLPFEDMLNFAAKLGIDTLEMTTGGWSPAPHLN LDELLQSSEKRKEFSQALEKRNMTLCALNCSGNPLDPGELGKSHRDITDKTMELAGLL GVKKVIMMSGLPAGGPDDKVPNWITYTVSWPPVLKDILNYQWEDVAIPYWKKLVKKAE ACGVGKIALENFSSQLVYNPETLFRLRNAVGPMVGLNLDPSHLLWMGADPIIAARELG SAIHHVHGKDVRIERYLSAVNGLLETKEVTDPANRAWNYVAVGCGQDLQWWKEFFSVV KMMGYEGEVSLEMEDLTMSPEAGIRTSVEALKQTISQ*" /label="yfiH CDS" gene 851132..852073 /gene="yfiH" /locus_tag="BSU_08270" /old_locus_tag="BSU08270" /label="yfiH gene" CDS 852083..853264 /gene="yfiI" /locus_tag="BSU_08280" /old_locus_tag="BSU08280" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26438878; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388709.1" /db_xref="EnsemblGenomes-Gn:BSU08280" /db_xref="EnsemblGenomes-Tr:CAB12657" /db_xref="GOA:P94437" /db_xref="InterPro:IPR000683" /db_xref="InterPro:IPR004104" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12214" /db_xref="UniProtKB/Swiss-Prot:P94437" /translation="MMLNGERIISKPLRWAMVGGGRLSQVGYKHRIGALRDNTAFQLT AGAFDIDAERGKDFGVNLGVDAERCYPNYQTMFAEEAKRQDGIEVVSIATPNGTHYEI CKAALEAGVHVICEKPLFFTSAEGQEIKALAEKKGKIVGVTYGFSGNQMLLQMRAMIE QGMIGDIRVVDLQYTHGFCATDEGEKISAAQKWRVDPAIAGPSFVLGDLSTHTYYMSQ LIMPKMKIKELLCDRQSFVGSRAPLEDNAHVLMHYENGAVGTMWTSSINAGCMDGHRI RIVGSKASIEWWDSKPNELTYEVQGEPGQTLVRGMPYLDDVCNADERLGALHSEGLSE AWANIYLKFAIAIDAKNREDEEILNNLVYPDIDAGIEGIRWIENCVRSANQGSVWVEF K*" /label="yfiI CDS" gene 852083..853264 /gene="yfiI" /locus_tag="BSU_08280" /old_locus_tag="BSU08280" /label="yfiI gene" downshifts 853254 /Source="Nicolas_upshifts" /id="D413" /incds=0 /nref=40 /ntot=113 /MaxReadThrough="0.88387" /MaxDrop="5.80704" /score="14.819468" /energy="-13" /TU="NA" /idTUdmin="U630" /TUdmin="-2003" /isTUend="FALSE" /label="downshifts" promotor_-35 853324..853330 /Source="Nicolas_upshift_promotors" /id="U630" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.517482517482518" /psig="0.918081918081918" /xcortree=2137 /SigmaFactorBS="cggtttttattttccagaaacTCCTGTCaaaaatgccctgag GCAGGTATGATAAGAAGGGAattgggtatcgggagtgatgagcgtgaaagctcttttt t" /listShort="yfiJ, yfiK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 853345..853364 /Source="Nicolas_upshift_promotors" /id="U630" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.517482517482518" /psig="0.918081918081918" /xcortree=2137 /SigmaFactorBS="cggtttttattttccagaaacTCCTGTCaaaaatgccctgag GCAGGTATGATAAGAAGGGAattgggtatcgggagtgatgagcgtgaaagctcttttt t" /listShort="yfiJ, yfiK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 853363 /Source="Nicolas_upshifts" /id="U630" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.517482517482518" /psig="0.918081918081918" /xcortree=2137 /SigmaFactorBS="cggtttttattttccagaaacTCCTGTCaaaaatgccctgag GCAGGTATGATAAGAAGGGAattgggtatcgggagtgatgagcgtgaaagctcttttt t" /listShort="yfiJ, yfiK" /GFF_Attribute="listLong" /label="upshifts" CDS 853388..854590 /gene="linJ" /locus_tag="BSU_08290" /old_locus_tag="BSU08290" /function="16.12: Sense" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11717295, 12618459, 28461449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 12618459, 28461449; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [LinK] (linearmycin resistance, biofilm formation)" /protein_id="NP_388710.1" /db_xref="EnsemblGenomes-Gn:BSU08290" /db_xref="EnsemblGenomes-Tr:CAB12658" /db_xref="GOA:P94438" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12215" /db_xref="UniProtKB/Swiss-Prot:P94438" /translation="MKALFFTRMFTLMVSCLMYLSIVKEDNWFGYVFIAAGAAMYAAN HVLLTKETNAIWFCLIDIAIGFSFGFIFPGTGLFIIMLCPVAVAFFLRGFPKRTAWSV LCLSSILFLTVLIRTYAMFGNEFVIDHLTSMTFVVFCGVVGKLIRKLLDAQDTAKQQF QELTESHLALSAAHQELHLYAKQVEELTAIYERNRMAREIHDTVGHKMTALLVQLQLL REWQKRDSQKADETVGVCETLAREALDDVRLSVRTLQTENDPSLIESLKQLTEDFCKN AGVTTEFAVSGDPAIIPLSLHPTLIRTVQEALTNAKRHGGAAACSIQLACTTDSISLV IKDDGKGNPEAALGFGLLNMKKRAAEHGGMIRFESERDQGFTVNAEFSLANKKWSFGP VQQKESLS*" /label="linJ CDS" gene 853388..854590 /gene="linJ" /locus_tag="BSU_08290" /old_locus_tag="BSU08290" /label="linJ gene" CDS 854587..855249 /gene="linK" /locus_tag="BSU_08300" /old_locus_tag="BSU08300" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 12618459, 28461449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 12618459, 28461449; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [LinJ] (linearmycin resistance, biofilm formation)" /protein_id="NP_388711.1" /db_xref="EnsemblGenomes-Gn:BSU08300" /db_xref="EnsemblGenomes-Tr:CAB12659" /db_xref="GOA:P94439" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12216" /db_xref="UniProtKB/Swiss-Prot:P94439" /translation="MIKIIITDDQDIVREGLASLLQLREELDVIATARNGQEAFEKAK ELEPDIVLMDIRMPVSNGVEGTKLITSSLPSVKVLMLTTFKDSALIAEALEEGASGYL LKDMSADTIVKAVMTVHSGGMVLPPELTAQMLNEWKREKQLKGINEIEKPNELLDLTE REIEVLAELGYGLNNKEIAEKLYITEGTVKNHVSNIISKLAVRDRTQAAIYSVRYGVS VF*" /label="linK CDS" gene 854587..855249 /gene="linK" /locus_tag="BSU_08300" /old_locus_tag="BSU08300" /label="linK gene" downshifts 855257 /Source="Nicolas_upshifts" /id="D414" /incds=0 /nref=114 /ntot=229 /MaxReadThrough="-0.0105699999999995" /MaxDrop="4.23231" /score="20.4785449" /energy="-7.6" /TU="NA" /idTUdmin="U630" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 855393..856328 /gene="bifL" /locus_tag="BSU_08310" /old_locus_tag="BSU08310" /function="16.8: Protect" /function="16.13: Shape" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:28461449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 28461449; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (ATP-binding protein) biofilm formation" /protein_id="NP_388712.2" /db_xref="EnsemblGenomes-Gn:BSU08310" /db_xref="EnsemblGenomes-Tr:CAB12660" /db_xref="GOA:P94440" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12217" /db_xref="UniProtKB/Swiss-Prot:P94440" /translation="MLQAENIKKAYGKKTIVKGISFSLKKGESFGLLGPNGAGKSTTI SMISGLVPHDSGNITVGGYVIGKETAKAKQKIGIVPQEIALYPTLTAHENLMFWGKMY GLTHGEAKKRAAEVLEYVGLTERAKDKIETFSGGMKRRINIGAALMHKPELLIMDEPT VGIDPQSRNHILETVKQLNETGMTVIYTSHYMEEVEFLCDRIGIIDQGEMIAIGTKTD LCSRLGGDTIIQLTVSGINEAFLVAIRSLAHVNDVTVHELELKIDISAAHHEKVVTSL LAEATAHHINLLSLQVQEPNLERLFLNLTGRTLRD*" /label="bifL CDS" gene 855393..856328 /gene="bifL" /locus_tag="BSU_08310" /old_locus_tag="BSU08310" /label="bifL gene" CDS 856341..857531 /gene="bifM" /locus_tag="BSU_08320" /old_locus_tag="BSU08320" /function="16.8: Protect" /function="16.13: Shape" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 28461449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 28461449; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (permease) biofilm formation" /protein_id="NP_388713.1" /db_xref="EnsemblGenomes-Gn:BSU08320" /db_xref="EnsemblGenomes-Tr:CAB12661" /db_xref="GOA:P94441" /db_xref="InterPro:IPR000412" /db_xref="SubtiList:BG12218" /db_xref="UniProtKB/Swiss-Prot:P94441" /translation="MKKSIWIAWKDVKIRITDRKGFMMLILMPLILTCILGAALGSVV DGGSRIDDIKVGYIQSDQSDTANMFTKDVLKKMKSIKVTKVGSKDKMKKLIDEKKIDV GIVIPNHWEAGKTSAVVNAAPDQTLKSSIIETAASSFIEQYKAVKEAASGSMDYISKT EAVKQGKLDPAQFAEKLAKTLEKETGDKLTIAEKSVGSKAVTSFQYYSAAMLCMFMLF HITVGAKSFLQEKDTETLARMLMTPAQKSVILFGKWLGTYLFAIIQFFIFLIVTINVF GVDWGGNLLLVSVLGLSYAAAVSGISMLLASCISDMKTADAIGGFGIQLLAVLGGSML PLYQFPDVLQSVSKAVPNRWALDGFLSLMEGGGWADLQKPVLLFAAIGFCSLVIGIRR LHTR*" /label="bifM CDS" gene 856341..857531 /gene="bifM" /locus_tag="BSU_08320" /old_locus_tag="BSU08320" /label="bifM gene" CDS 857545..858702 /gene="bifN" /locus_tag="BSU_08330" /old_locus_tag="BSU08330" /function="16.8: Protect" /function="16.13: Shape" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 28461449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 28461449; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (permease) biofilm formation" /protein_id="NP_388714.1" /db_xref="EnsemblGenomes-Gn:BSU08330" /db_xref="EnsemblGenomes-Tr:CAB12662" /db_xref="GOA:P94442" /db_xref="InterPro:IPR000412" /db_xref="SubtiList:BG12219" /db_xref="UniProtKB/Swiss-Prot:P94442" /translation="MKKILAICGIELSLIFKKPQNYLIMFAAPLLLTFVFGSMLSGND DKVRLAIVDQDDTILSQHYIRQLKAHDDMYVFENMSESKASEKLKQKKIAGIIVISRS FQTQLEKGKHPELIFRHGPELSEAPMVKQYAESALATLNIQVTAAKTASQTAGENWKA AYKTVFAKKHEDIVPAVTRQTLSDKKEGAEASDTASRAAGFSILFVMLTMMGAAGTIL EARKNGVWSRLLTASVSRAEIGAGYVLSFFVIGWIQFGILLLSTHWLFGINWGNPAAV IVLVSLFLLTVVGIGLMIAANVRTPEQQLAFGNLFVIATCMVSGMYWPIDIEPKFMQS IAEFLPQKWAMSGLTEIIANGARVTDILGICGILLAFAAITFAAGLKALRA*" /label="bifN CDS" gene 857545..858702 /gene="bifN" /locus_tag="BSU_08330" /old_locus_tag="BSU08330" /label="bifN gene" promotor_-35 857656..857661 /Source="Nicolas_upshift_promotors" /id="U631" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.693306693306693" /psig="0.693306693306693" /xcortree=1182 /SigmaFactorBS="atgtttgctgccccgcttttgcttacctttgtatttgggAGT ATGctcagcggcaatgaTGATAAGGTGCGGCTTGCAatcgttgatcaggacgatacga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 857676..857694 /Source="Nicolas_upshift_promotors" /id="U631" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.693306693306693" /psig="0.693306693306693" /xcortree=1182 /SigmaFactorBS="atgtttgctgccccgcttttgcttacctttgtatttgggAGT ATGctcagcggcaatgaTGATAAGGTGCGGCTTGCAatcgttgatcaggacgatacga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 857677 /Source="Nicolas_upshifts" /id="U631" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.693306693306693" /psig="0.693306693306693" /xcortree=1182 /SigmaFactorBS="atgtttgctgccccgcttttgcttacctttgtatttgggAGT ATGctcagcggcaatgaTGATAAGGTGCGGCTTGCAatcgttgatcaggacgatacga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(858700..858774) /Source="Nicolas_S_feature" /locus_tag="new_909123_909197_c" /HighExp="LoTm, Sw, C90, HiOs, BC, MG 45, UNK1, Fru, S1, BI" /AntisenseName="yfiN" /AntisenseCor="-6.3486715356968801E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S284" downshifts complement(858743) /Source="Nicolas_upshifts" /id="D415" /incds=0 /nref=90 /ntot=257 /MaxReadThrough="1.41433" /MaxDrop="6.01369" /score="13.7314837" /energy="-11.5" /TU="U632" /idTUdmin="U632" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(858775..859323) /gene="padR" /locus_tag="BSU_08340" /old_locus_tag="BSU08340" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11073918, 17295427, 18326577, 21685295, 23189126, 27716049, 28027933" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11073918, 17295427, 18326577, 21685295, 23189126, 27716049, 28027933; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of phenolic acid decarboxylase" /protein_id="NP_388715.1" /db_xref="EnsemblGenomes-Gn:BSU08340" /db_xref="EnsemblGenomes-Tr:CAB12663" /db_xref="GOA:P94443" /db_xref="InterPro:IPR005149" /db_xref="InterPro:IPR018309" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12220" /db_xref="UniProtKB/Swiss-Prot:P94443" /translation="MRVLKYAILGLLRKGELSGYDITSYFKEELGQFWSAKHSQIYPE LKKLTDEGFITFRTTIQGTKLEKKMYTLTDSGKQELHDWLIRHQPIPETVKDEFMLKA YFISCLSRQEASDLFKDQLQKRQAKLSDLQGSYEKLMASAEPMSFSSPDFGHYLVLTK ALEREKNYVSWLESILAMIDKD*" /label="padR CDS" gene complement(858775..859323) /gene="padR" /locus_tag="BSU_08340" /old_locus_tag="BSU08340" /label="padR gene" S_feature complement(859324..859403) /Source="Nicolas_S_feature" /locus_tag="new_909747_909826_c" /HighExp="LoTm, Cold, G180, GM-0.2, Oxctl, T5.0H, GM 25, T3.30H, MG 60, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S285" promotor_-10 complement(859392..859411) /Source="Nicolas_upshift_promotors" /id="U632" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.405594405594406" /psig="0.997002997002997" /xcortree=2251 /SigmaFactorBS="acaaaccttttatcttcatttccaaagagcccgGTTGTGttc ccttcctcccTTTTCTATAATAAGGGGAATaggcagttagaatcacagttgagcaccg g" /listShort="S285, padR, S284" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(859403) /Source="Nicolas_upshifts" /id="U632" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.405594405594406" /psig="0.997002997002997" /xcortree=2251 /SigmaFactorBS="acaaaccttttatcttcatttccaaagagcccgGTTGTGttc ccttcctcccTTTTCTATAATAAGGGGAATaggcagttagaatcacagttgagcaccg g" /listShort="S285, padR, S284" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(859425..859430) /Source="Nicolas_upshift_promotors" /id="U632" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.405594405594406" /psig="0.997002997002997" /xcortree=2251 /SigmaFactorBS="acaaaccttttatcttcatttccaaagagcccgGTTGTGttc ccttcctcccTTTTCTATAATAAGGGGAATaggcagttagaatcacagttgagcaccg g" /listShort="S285, padR, S284" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 859526..859529 /Source="Nicolas_upshift_promotors" /id="U633" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.927072927072927" /psig="0.998001998001998" /xcortree=2321 /SigmaFactorBS="tataaaagagatttaaatttaattttcagaaaaaATAGtaac gatattgatttTTTATATATAATAGGAAATTggtggtatgaaaattttttgggggaat a" /listShort="estB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 859545..859564 /Source="Nicolas_upshift_promotors" /id="U633" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.927072927072927" /psig="0.998001998001998" /xcortree=2321 /SigmaFactorBS="tataaaagagatttaaatttaattttcagaaaaaATAGtaac gatattgatttTTTATATATAATAGGAAATTggtggtatgaaaattttttgggggaat a" /listShort="estB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 859552 /Source="Nicolas_upshifts" /id="U633" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.927072927072927" /psig="0.998001998001998" /xcortree=2321 /SigmaFactorBS="tataaaagagatttaaatttaattttcagaaaaaATAGtaac gatattgatttTTTATATATAATAGGAAATTggtggtatgaaaattttttgggggaat a" /listShort="estB" /GFF_Attribute="listLong" /label="upshifts" CDS 859596..860228 /gene="estB" /locus_tag="BSU_08350" /old_locus_tag="BSU08350" /EC_number="3.1.1.3" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11029590, 10913700, 21574267" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11029590, 10913700, 21574267; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="secreted esterase / acylglycerol lipase" /protein_id="NP_388716.1" /db_xref="EnsemblGenomes-Gn:BSU08350" /db_xref="EnsemblGenomes-Tr:CAB12664" /db_xref="GOA:Q79F14" /db_xref="InterPro:IPR002918" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG11951" /db_xref="UniProtKB/Swiss-Prot:Q79F14" /translation="MKKVLMAFIICLSLILSVLAAPPSGAKAESVHNPVVLVHGISGA SYNFFAIKNYLISQGWQSNKLYAIDFYDKTGNNLNNGPQLASYVDRVLKETGAKKVDI VAHSMGGANTLYYIKYLGGGNKIQNVVTLGGANGLVSSTALPGTDPNQKILYTSIYSL NDQIVINSLSRLQGARNIQLYGIGHIGLLSNSQVNGYIKEGLNGGGLNTN*" /label="estB CDS" gene 859596..860228 /gene="estB" /locus_tag="BSU_08350" /old_locus_tag="BSU08350" /label="estB gene" downshifts 860207 /Source="Nicolas_upshifts" /id="D416" /incds=0 /nref=7 /ntot=100 /MaxReadThrough="0.87881" /MaxDrop="2.6151" /score="0.223019698" /energy="-8.5" /TU="NA" /idTUdmin="U633" /TUdmin=88 /isTUend="FALSE" /label="downshifts" promotor_-35 860343..860348 /Source="Nicolas_upshift_promotors" /id="U634" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.492507492507492" /psig="0.984015984015984" /xcortree=3160 /SigmaFactorBS="tcatgcatacgtcaatttatgacatcaggcaCTTTTTcaaat agagcggaCATGTTAAGGTACAACCATCgatttctatcaatttgaaataaaaggagcg c" /listShort="yfiQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 860362..860381 /Source="Nicolas_upshift_promotors" /id="U634" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.492507492507492" /psig="0.984015984015984" /xcortree=3160 /SigmaFactorBS="tcatgcatacgtcaatttatgacatcaggcaCTTTTTcaaat agagcggaCATGTTAAGGTACAACCATCgatttctatcaatttgaaataaaaggagcg c" /listShort="yfiQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 860372 /Source="Nicolas_upshifts" /id="U634" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.492507492507492" /psig="0.984015984015984" /xcortree=3160 /SigmaFactorBS="tcatgcatacgtcaatttatgacatcaggcaCTTTTTcaaat agagcggaCATGTTAAGGTACAACCATCgatttctatcaatttgaaataaaaggagcg c" /listShort="yfiQ" /GFF_Attribute="listLong" /label="upshifts" CDS 860417..861505 /gene="icaC" /locus_tag="BSU_08360" /old_locus_tag="BSU08360" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16850406, 24776724, 25935415, 27303652; Product type t : transporter" /codon_start=1 /transl_table=11 /product="acetyl-glucosamine metabolite exporter componentinvolved in biofilm formation" /protein_id="NP_388717.1" /db_xref="EnsemblGenomes-Gn:BSU08360" /db_xref="EnsemblGenomes-Tr:CAB12665" /db_xref="GOA:O31559" /db_xref="InterPro:IPR002656" /db_xref="SubtiList:BG12893" /db_xref="UniProtKB/Swiss-Prot:O31559" /translation="MQIKEIFMIRCISCLSVVLLHIISMVLMLQAEALADISHTVDSF RTLLMFSTPAFIFISEFLLARSYPDGVPDGFLKKRGKVIFVPFLFIAAIDALLMTSAM GGEVTFLAFVQKYLANVFLGNFIGYFILVIFQFYMLHMMFHEYLKKASPKWVLSISFV VTAAYLGYFSAASPAPASEEGGAFPFFWVPFAGWLFYFCLAYYCGKEYKRFLALLNQY RWVVYGAAIASGALVVTVSYVGEIGMISSKRPDIMLYSTSMIFLCFHLFSKMKHVPKI MMFISNYSFSIYLLHAYFMIIGYVLLLNMPEIPAVPAVLLLFAVCTAGPIMTSWALNK FKYGYLFVGKIYQPKQKKVTVEVRDHAG*" /label="icaC CDS" gene 860417..861505 /gene="icaC" /locus_tag="BSU_08360" /old_locus_tag="BSU08360" /label="icaC gene" S_feature complement(860907..861295) /Source="Nicolas_S_feature" /locus_tag="new_911330_911718_c" /HighExp="S6, S8, S7, S5, LBGstat, H2O2, Mt0, Cold, G180, LPhT" /AntisenseName="yfiQ" /AntisenseCor="0.36913176163336098" /AntisenseRegPval="-9.4" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.976" /TUlongSig="NA" /TUlongPSig="NA" /label="S286" upshifts complement(861295) /Source="Nicolas_upshifts" /id="U635" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1391 /SigmaFactorBS="agccggtacggcaggaatTTCGGGCATattcaaaagcaaCAC GTAGCCTATAATCATAAaataggcatgaagcagataaatcgaaaaggaatagttgctg a" /listShort="S286" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(861297..861316) /Source="Nicolas_upshift_promotors" /id="U635" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1391 /SigmaFactorBS="agccggtacggcaggaatTTCGGGCATattcaaaagcaaCAC GTAGCCTATAATCATAAaataggcatgaagcagataaatcgaaaaggaatagttgctg a" /listShort="S286" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(861329..861337) /Source="Nicolas_upshift_promotors" /id="U635" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1391 /SigmaFactorBS="agccggtacggcaggaatTTCGGGCATattcaaaagcaaCAC GTAGCCTATAATCATAAaataggcatgaagcagataaatcgaaaaggaatagttgctg a" /listShort="S286" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(861541..862158) /gene="yfiR" /locus_tag="BSU_08370" /old_locus_tag="BSU08370" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16862575" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16862575; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (TetR/AcrR family)" /protein_id="NP_388718.1" /db_xref="EnsemblGenomes-Gn:BSU08370" /db_xref="EnsemblGenomes-Tr:CAB12666" /db_xref="GOA:O31560" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="PDB:1RKT" /db_xref="SubtiList:BG12894" /db_xref="UniProtKB/Swiss-Prot:O31560" /translation="MSPKVTKEHKDKRQAEILEAAKTVFKRKGFELTTMKDVVEESGF SRGGVYLYFSSTEEMFRRIIETGLDEGLRKLDKSAEHQSVWASISSYLDELTEGLRDV ADTLAPVQFEYLVTAWRNEERRQYLEKRYDLFVERFSRLLQKGIDQGEFQPVQPLATI AKFFLNMNDGIIQNALYFDEEKADVSGLAESAKLYLKTVLQADEK*" /label="yfiR CDS" gene complement(861541..862158) /gene="yfiR" /locus_tag="BSU_08370" /old_locus_tag="BSU08370" /label="yfiR gene" downshifts complement(861559) /Source="Nicolas_upshifts" /id="D417" /incds=0 /nref=29 /ntot=209 /MaxReadThrough="2.44114" /MaxDrop="4.07715" /score="22.1532141" /energy="-17.1" /TU="NA" /idTUdmin="U636" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(862124..863377) /gene="yfiS" /locus_tag="BSU_08380" /old_locus_tag="BSU08380" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9811639, 15849754, 16850406, 16862575; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388719.1" /db_xref="EnsemblGenomes-Gn:BSU08380" /db_xref="EnsemblGenomes-Tr:CAB12667" /db_xref="GOA:O31561" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12895" /db_xref="UniProtKB/Swiss-Prot:O31561" /translation="MEKPLFRNQKGLMTLLASQTISSLGDWLHILAVLTLAAFQLHAS PLDMSLLMMSFALPVIVLGPVSGLLADRFDRKTIMFLSEIGRALTVISCVYVSELWQL YVLLSVQSCFSSLFLPAKNGKLKELAPEAHIQQAVSVSSIIDNSSKIFGPALGGTLIA AFSIHSVFYINAGAFFLSAVILFFLPRDAFLQKANTPQEKTAALTSIKEGLQFLKRMP LLLTGLLTACVVLFVLQIGDSQAIILIRSFSGAPPELAGWCMAVSGAGMLLTAAITGR RRITSYLLYFSAGTLLLGLATGGAPFLSGMGIAGITLFIFAFFIMGAAFGLVHIPFQI LVQTTVPVDYSGRVFGAIQSATTLASILGMAGGGVLAEWIGVSLAFLVCGCLLIMIGL ITLIGKKIAESRRYLVTKSNKGAQG*" /label="yfiS CDS" gene complement(862124..863377) /gene="yfiS" /locus_tag="BSU_08380" /old_locus_tag="BSU08380" /label="yfiS gene" promotor_-10 complement(862185..862204) /Source="Nicolas_upshift_promotors" /id="U636" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.918081918081918" /psig="0.998001998001998" /xcortree=3148 /SigmaFactorBS="tcggtgtatcacttgcttttcttgtctgtggcTGCTTGCTga tcatgattgggTTGATTACACTTATAGGTAAgaaaattgcagaaagcaggcgatatct t" /listShort="yfiR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(862197) /Source="Nicolas_upshifts" /id="U636" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.918081918081918" /psig="0.998001998001998" /xcortree=3148 /SigmaFactorBS="tcggtgtatcacttgcttttcttgtctgtggcTGCTTGCTga tcatgattgggTTGATTACACTTATAGGTAAgaaaattgcagaaagcaggcgatatct t" /listShort="yfiR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(862218..862225) /Source="Nicolas_upshift_promotors" /id="U636" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.918081918081918" /psig="0.998001998001998" /xcortree=3148 /SigmaFactorBS="tcggtgtatcacttgcttttcttgtctgtggcTGCTTGCTga tcatgattgggTTGATTACACTTATAGGTAAgaaaattgcagaaagcaggcgatatct t" /listShort="yfiR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(863411..863430) /Source="Nicolas_upshift_promotors" /id="U637" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.492507492507492" /psig="0.99100899100899" /xcortree=2727 /SigmaFactorBS="cttctattcaatcttctcctttattttacaagaaaaaGATTG TATattgtgtctttttcCCATACAATTAAAAACGACActagtgtcattttaataatca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(863429) /Source="Nicolas_upshifts" /id="U637" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.492507492507492" /psig="0.99100899100899" /xcortree=2727 /SigmaFactorBS="cttctattcaatcttctcctttattttacaagaaaaaGATTG TATattgtgtctttttcCCATACAATTAAAAACGACActagtgtcattttaataatca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(863445..863452) /Source="Nicolas_upshift_promotors" /id="U637" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.492507492507492" /psig="0.99100899100899" /xcortree=2727 /SigmaFactorBS="cttctattcaatcttctcctttattttacaagaaaaaGATTG TATattgtgtctttttcCCATACAATTAAAAACGACActagtgtcattttaataatca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 863456..863475 /Source="Nicolas_upshift_promotors" /id="U638" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.77022977022977" /psig="0.98901098901099" /xcortree=3204 /SigmaFactorBS="atgacactagtgtcgtttttaattgtatgggaaaaagacaca atatacaatctttTTCTTGTAAAATAAAGGAGAagattgaatagaagggagaacattc a" /listShort="yfiT" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 863461 /Source="Nicolas_upshifts" /id="U638" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.77022977022977" /psig="0.98901098901099" /xcortree=3204 /SigmaFactorBS="atgacactagtgtcgtttttaattgtatgggaaaaagacaca atatacaatctttTTCTTGTAAAATAAAGGAGAagattgaatagaagggagaacattc a" /listShort="yfiT" /GFF_Attribute="listLong" /label="upshifts" CDS 863501..864037 /gene="bstA" /locus_tag="BSU_08390" /old_locus_tag="BSU08390" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15581359, 22059487, 24821014, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15581359, 22059487, 24821014, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bacillithiol S-transferase" /protein_id="NP_388720.1" /db_xref="EnsemblGenomes-Gn:BSU08390" /db_xref="EnsemblGenomes-Tr:CAB12668" /db_xref="GOA:O31562" /db_xref="InterPro:IPR023774" /db_xref="InterPro:IPR024775" /db_xref="InterPro:IPR034660" /db_xref="PDB:1RXQ" /db_xref="SubtiList:BG12896" /db_xref="UniProtKB/Swiss-Prot:O31562" /translation="MTSVNLSYPIGEYKPRESISKEQKDKWIQVLEEVPAKLKQAVEV MTDSQLDTPYRDGGWTVRQVVHHLADSHMNSYIRFKLSLTEETPAIRPYDEKAWSELK DSKTADPSGSLALLQELHGRWTALLRTLTDQQFKRGFYHPDTKEIITLENALGLYVWH SHHHIAHITELSRRMGWS*" /label="bstA CDS" gene 863501..864037 /gene="bstA" /locus_tag="BSU_08390" /old_locus_tag="BSU08390" /label="bstA gene" CDS complement(864034..865590) /gene="yfiU" /locus_tag="BSU_08400" /old_locus_tag="BSU08400" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388721.1" /db_xref="EnsemblGenomes-Gn:BSU08400" /db_xref="EnsemblGenomes-Tr:CAB12669" /db_xref="GOA:O31563" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12897" /db_xref="UniProtKB/Swiss-Prot:O31563" /translation="MSEALTEQKSQKWAISLFTIGVFMAALDNGIISAALTTINESFS VSPSWGSWGITLYTLGLSVSVPIVGKLSDRYGRKKLFLIEVCLFGLGSLLVALSQSFP LFLISRLIQALGGGGIFIIGSSHILATLPKEKQGKALGLLGAMNGMAAVLGPNIGSFL LDWTGSWHWLFLINLPIAVLLVVFGACFIAETKAPEAKRLDAAGIFLLSLSILAVMYG MTNLDGANLLHSLGNPEVYGCIIFGILCFAALISYEKRVEMRGGDPILAYSLLRNHMF QRTLIIGLLSGGLLAAVIFIPSYVEQYLGVPAAKAGYWMTPLALASGIGAWLGGALTD KKGPVKTVILSGIISCAGFALFPLWVTEKWEFVIASVAAGIGFGFLLGAPLNVLVSEA AKTNKGTALGTLSLVRQIGLTLAPTLYAGFITAGFDQIGDEINSRLSDSGYSEKAMQM IPEIDSSEVSSLQEQIERIPVPEVKTAISDAIHASVASGYDHLYAAAAVVSLLVIAAI SIPAFRRQKR*" /label="yfiU CDS" gene complement(864034..865590) /gene="yfiU" /locus_tag="BSU_08400" /old_locus_tag="BSU08400" /label="yfiU gene" promotor_-10 complement(865612..865630) /Source="Nicolas_upshift_promotors" /id="U639" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.623376623376623" /psig="0.623376623376623" /xcortree=795 /SigmaFactorBS="tgtcatccgcaaactgcgggagcaggctttttttatttgaCA TTtagttcatttaaaatGAATAATATATTTCAAGTGaactaaaaggagttgacgaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(865629) /Source="Nicolas_upshifts" /id="U639" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.623376623376623" /psig="0.623376623376623" /xcortree=795 /SigmaFactorBS="tgtcatccgcaaactgcgggagcaggctttttttatttgaCA TTtagttcatttaaaatGAATAATATATTTCAAGTGaactaaaaggagttgacgaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(865646..865649) /Source="Nicolas_upshift_promotors" /id="U639" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.623376623376623" /psig="0.623376623376623" /xcortree=795 /SigmaFactorBS="tgtcatccgcaaactgcgggagcaggctttttttatttgaCA TTtagttcatttaaaatGAATAATATATTTCAAGTGaactaaaaggagttgacgaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(865701..866183) /gene="yfiV" /locus_tag="BSU_08410" /old_locus_tag="BSU08410" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 18990441; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)" /protein_id="NP_388722.1" /db_xref="EnsemblGenomes-Gn:BSU08410" /db_xref="EnsemblGenomes-Tr:CAB12670" /db_xref="GOA:O31564" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12898" /db_xref="UniProtKB/Swiss-Prot:O31564" /translation="MEYNLHDTTVLNENILSSEEREIWVLYMKVLTSAGLGDVSEWMK LDMSMPQMKVLMLLNNHGTLKVSDIAEKMGASLSNTTGLLDRLEKSGFVKRSHSEEDR RSVVVQLTENAKKIFRGLYEKGHLKLKRSLELLSPEEKQAVYEGLSILSRALENAKKE *" /label="yfiV CDS" gene complement(865701..866183) /gene="yfiV" /locus_tag="BSU_08410" /old_locus_tag="BSU08410" /label="yfiV gene" downshifts complement(865717) /Source="Nicolas_upshifts" /id="D418" /incds=0 /nref=58 /ntot=177 /MaxReadThrough="1.47849" /MaxDrop="4.15907" /score="27.2704527" /energy="-14.2" /TU="NA" /idTUdmin="U640" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(866208..866227) /Source="Nicolas_upshift_promotors" /id="U640" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.542457542457542" /psig="0.998001998001998" /xcortree=2019 /SigmaFactorBS="atttttcggacaaagtcccgcatgcggtttctgctcACTTTC TttcaggagtgaaaaTCGAGTAATATGGTAAGAGGagtgaatgatgaggaagtgatga a" /listShort="yfiV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(866224) /Source="Nicolas_upshifts" /id="U640" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.542457542457542" /psig="0.998001998001998" /xcortree=2019 /SigmaFactorBS="atttttcggacaaagtcccgcatgcggtttctgctcACTTTC TttcaggagtgaaaaTCGAGTAATATGGTAAGAGGagtgaatgatgaggaagtgatga a" /listShort="yfiV" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(866242..866248) /Source="Nicolas_upshift_promotors" /id="U640" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.542457542457542" /psig="0.998001998001998" /xcortree=2019 /SigmaFactorBS="atttttcggacaaagtcccgcatgcggtttctgctcACTTTC TttcaggagtgaaaaTCGAGTAATATGGTAAGAGGagtgaatgatgaggaagtgatga a" /listShort="yfiV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 866269..866276 /Source="Nicolas_upshift_promotors" /id="U641" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.544455544455544" /psig=1 /xcortree=2519 /SigmaFactorBS="tgaaagaaagtgagcagaaaccgcatgcgggACTTTGTCcga aaaataacggTAGTGTATAATGAGTTGGAGattattgggggagaggatcgaactagaa t" /listShort="mprF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 866290..866309 /Source="Nicolas_upshift_promotors" /id="U641" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.544455544455544" /psig=1 /xcortree=2519 /SigmaFactorBS="tgaaagaaagtgagcagaaaccgcatgcgggACTTTGTCcga aaaataacggTAGTGTATAATGAGTTGGAGattattgggggagaggatcgaactagaa t" /listShort="mprF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 866298 /Source="Nicolas_upshifts" /id="U641" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.544455544455544" /psig=1 /xcortree=2519 /SigmaFactorBS="tgaaagaaagtgagcagaaaccgcatgcgggACTTTGTCcga aaaataacggTAGTGTATAATGAGTTGGAGattattgggggagaggatcgaactagaa t" /listShort="mprF" /GFF_Attribute="listLong" /label="upshifts" CDS 866355..868925 /gene="mprF" /locus_tag="BSU_08425" /old_locus_tag="BSU08425" /EC_number="2.3.2.3" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:2139213, 2490162, 12427923, 14702396, 15849754, 16299297, 16850406, 17042784, 19074395, 21306448, 26261323" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2139213, 2490162, 12427923, 14702396, 15849754, 16299297, 16850406, 17042784, 19074395, 21306448, 26261323; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="phosphatidylglycerol lysyltransferase involved in tRNA-dependent lysinylation of phospholipids" /protein_id="YP_003097695.1" /db_xref="EnsemblGenomes-Gn:BSU08425" /db_xref="EnsemblGenomes-Tr:CAX52582" /db_xref="GOA:C0H3X7" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR022791" /db_xref="InterPro:IPR024320" /db_xref="UniProtKB/Swiss-Prot:C0H3X7" /translation="MLIKKNALSILKIVFPIAVLLFVIYQSKKELTNLSFKRTLMVIN GLERTDLFMLVLIGLLAVAAMSLYDYVLKYSLRLSITNGKVFRVSWIANSFNNVLGFG GLAGVGLRMMFYKEHTKDHKALVKGIAWLTSSMLLGLSVFSIFVAARVLPVDEVIHEK PWLWAVVIGFALILPLSLAVSKIKDRKAGDEENADKVKNPIFAYIGASVVEWLMAGTV IYFALFAMGIHADIRYVFGVFVIAAIGGMISLVPGGFGSFDLLFLLGMEQLGYHQEAI VTSIVLYRLAYSFIPFILGLFFAAGDLTENTMKRLETNPRIAPAIETTNVLLVVQRAV LVRILQGSLSLIVFVAGLIVLASVSLPIDRLTVIPHIPRPALLLFNGLSLSSALILLI LPIELYKRTKRSYTMAITALVGGFVFSFLKGLNISAIFVLPMIIVLLVLLKKQFVREQ ASYTLGQLIFAVALFTVALFNYNLIAGFIWDRMKKVLRHEYFVHSTSHITHATIMAII IVPLFFLIFTVVYHKRTKPIGEKADPERLAAFLNEKGGNALSHLGFLGDKRFYFSSDG NALLLFGKIARRLVVLGDPSGQRESFPLVLEEFLNEAHQKGFSVLFYQIEREDMALYH DFGYNFFKLGEEAYVDLNTFTLTGKKKAGLRAINNRFEREEYTFHVDHPPFSDAFLEE LKQISDEWLGSKKEKGFSLGFFDPSYLQKAPIAYMKNAEGEIVAFANVMPMYQEGEIS VDLMRYRGDAPNGIMDALFIRMFLWAKEEGCTSFNMGMAPLANVGTAFTSFWSERFAA VIFNNVRYMYSFSGLRAFKEKYKPEWRGKYLAYRKNRSLSVTMFLVTRLIGKSKKDSV *" /label="mprF CDS" gene 866355..868925 /gene="mprF" /locus_tag="BSU_08425" /old_locus_tag="BSU08425" /label="mprF gene" downshifts 868896 /Source="Nicolas_upshifts" /id="D419" /incds=0 /nref=121 /ntot=252 /MaxReadThrough="1.79352" /MaxDrop="5.78159" /score="49.2396824" /energy="-16.1" /TU="NA" /idTUdmin="U641" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(868943..869920) /gene="sxzY" /locus_tag="BSU_08440" /old_locus_tag="BSU08440" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 12354229, 19254027, 24606332; Product type t: transporter" /codon_start=1 /transl_table=11 /product="xenosiderophore schizokinen (dihydroxamate) transporter binding lipoprotein" /protein_id="NP_388725.1" /db_xref="EnsemblGenomes-Gn:BSU08440" /db_xref="EnsemblGenomes-Tr:CAB12673" /db_xref="GOA:O31567" /db_xref="InterPro:IPR002491" /db_xref="SubtiList:BG12901" /db_xref="UniProtKB/Swiss-Prot:O31567" /translation="MKKHISMLFVFLMAVMVLSACNSSESSSNSEVSSSKTRTVKHAM GTSDNIPANPKRIVVLTNEGTEALLALGIKPVGAVKSWKGDPWYDYLKDDMKGVKNVG LETEPNVEAIAELKPDLIIGNKVRQEKIYDQLNAIAPTVFAESLAGNWKDNLTLYANA VNKADKGKEVIADFDKRVSDLKNKLGDQTNKTVSVVRFLSGESRIYYTDSFPGIILDQ LGFKRPEKQVELFKKQKDQFTFSTDSKESIPDMDADVLFYFTYKADNAKENEKWANQW TSSSLWKNLKAVKSGNAHEVDDVVWTTAGGIKAANYLLDDIETYFLKTK*" /label="sxzY CDS" gene complement(868943..869920) /gene="sxzY" /locus_tag="BSU_08440" /old_locus_tag="BSU08440" /label="sxzY gene" downshifts complement(868954) /Source="Nicolas_upshifts" /id="D420" /incds=0 /nref=165 /ntot=248 /MaxReadThrough="1.28876" /MaxDrop="7.70135" /score="35.2605181" /energy="-16.1" /TU="NA" /idTUdmin="U643" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" promotor_-35 869935..869942 /Source="Nicolas_upshift_promotors" /id="U642" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.458541458541459" /psig="0.998001998001998" /xcortree=2100 /SigmaFactorBS="gcatgctgatatgctttttcatctttttcctcccaaTATTGA AAttcattatcatttaGATCATAATAAGCAGTGTTAagagtgtcaatccctaattgag g" /listShort="S287, yfiZ, yfhA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(869947..869966) /Source="Nicolas_upshift_promotors" /id="U643" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96003996003996" /psig=1 /xcortree=2109 /SigmaFactorBS="tgtaatgtttgtttttgagaataatcctcaattaggGATTGA CActcttaacactgctTATTATGATCTAAATGATAAtgaatttcaatattgggaggaa a" /listShort="yfiY" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 869957..869976 /Source="Nicolas_upshift_promotors" /id="U642" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.458541458541459" /psig="0.998001998001998" /xcortree=2100 /SigmaFactorBS="gcatgctgatatgctttttcatctttttcctcccaaTATTGA AAttcattatcatttaGATCATAATAAGCAGTGTTAagagtgtcaatccctaattgag g" /listShort="S287, yfiZ, yfhA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 869959..870050 /Source="Nicolas_S_feature" /locus_tag="new_920382_920473" /HighExp="dia0, Lbexp, LBGexp, H2O2, G150, GM 10, Oxctl, dia15, Paraq, GM 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S287" upshifts 869959 /Source="Nicolas_upshifts" /id="U642" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.458541458541459" /psig="0.998001998001998" /xcortree=2100 /SigmaFactorBS="gcatgctgatatgctttttcatctttttcctcccaaTATTGA AAttcattatcatttaGATCATAATAAGCAGTGTTAagagtgtcaatccctaattgag g" /listShort="S287, yfiZ, yfhA" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(869964) /Source="Nicolas_upshifts" /id="U643" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96003996003996" /psig=1 /xcortree=2109 /SigmaFactorBS="tgtaatgtttgtttttgagaataatcctcaattaggGATTGA CActcttaacactgctTATTATGATCTAAATGATAAtgaatttcaatattgggaggaa a" /listShort="yfiY" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(869981..869988) /Source="Nicolas_upshift_promotors" /id="U643" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96003996003996" /psig=1 /xcortree=2109 /SigmaFactorBS="tgtaatgtttgtttttgagaataatcctcaattaggGATTGA CActcttaacactgctTATTATGATCTAAATGATAAtgaatttcaatattgggaggaa a" /listShort="yfiY" /GFF_Attribute="listLong" /label="promotor_-35" CDS 870051..871052 /gene="sxzZ" /locus_tag="BSU_08450" /old_locus_tag="BSU08450" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16672620, 16850406, 19254027" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16672620, 16850406, 19254027; Product type t : transporter" /codon_start=1 /transl_table=11 /product="xenosiderophore schizokinen (dihydroxamate) transporter (permease)" /protein_id="NP_388726.1" /db_xref="EnsemblGenomes-Gn:BSU08450" /db_xref="EnsemblGenomes-Tr:CAB12674" /db_xref="GOA:O31568" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12902" /db_xref="UniProtKB/Swiss-Prot:O31568" /translation="MICKKASSKWIVLVCLIFILLTAVCASVVYGYTGTSWRQVYQAF TSFNGTNEHVIIKDVRLPRALVATVVGASLAAAGALMQALTKNPLASPGIFGINAGAG FFIVAGSFFLHIQSPQALVWSSFLGAAFTAAIVYAAGSLGREGLTPIKLTLAGAAMAA MFSSLTQGLLSVNELELAQVLFWLTGSVQGRSLDLLMTMFPYAAAALVICFFLGQKIN LLVMGEDVAKGLGQKTGLLKFVMALCVVMLAGSAVAIAGPISFIGIIIPHFARFVVGN DYRWVLPFSAVLGAILLVCADIGARYIIMPQEVPVGVMTAIIGMPVFVYIARRGAKL* " /label="sxzZ CDS" gene 870051..871052 /gene="sxzZ" /locus_tag="BSU_08450" /old_locus_tag="BSU08450" /label="sxzZ gene" CDS 871049..872080 /gene="sxzA" /locus_tag="BSU_08460" /old_locus_tag="BSU08460" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16672620, 16850406, 19254027" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16672620, 16850406, 19254027; Product type t : transporter" /codon_start=1 /transl_table=11 /product="xenosiderophore schizokinen (dihydroxamate) transporter (permease)" /protein_id="NP_388727.1" /db_xref="EnsemblGenomes-Gn:BSU08460" /db_xref="EnsemblGenomes-Tr:CAB12675" /db_xref="GOA:O31569" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12876" /db_xref="UniProtKB/Swiss-Prot:O31569" /translation="MKLRFGVTAAEKKAWIVFLVLLGLTAAVLIISAGLGQRFIPPWD VAKTFFGAGSKLDELMIMSFRMPRILTALCAGVCLAAAGAILQGLVRNPLASPDIIGI TGGAAVAVVLLMMFFSDRSSSLTISLSWLPAAAFIGASAVGLIVYLLAYKNGASTFRL VLIGIGFSMSAQAMTTLLMIKGPIYRASQANVYITGSVYGSNWQHVKIAIILSVILLF ICFVALKNMNIQVLGEDIAAGAGSAVQRNRFFLLLLSTALTGCAVSVAGTIGFVGLMA PHIARRLVGSSYGALLPASALIGALLVLTADIVGRTLFAPVEVPAGVFTAAIGAPYFI YLLYKTRNS*" /label="sxzA CDS" gene 871049..872080 /gene="sxzA" /locus_tag="BSU_08460" /old_locus_tag="BSU08460" /label="sxzA gene" downshifts 872061 /Source="Nicolas_upshifts" /id="D421" /incds=0 /nref=24 /ntot=154 /MaxReadThrough="3.26686" /MaxDrop="4.27732" /score="19.6751667" /energy="-12.8" /TU="NA" /idTUdmin="U642" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" promotor_-35 872131..872133 /Source="Nicolas_upshift_promotors" /id="U644" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.945054945054945" /psig="0.999000999001" /xcortree=2943 /SigmaFactorBS="attttcttaaaaaagaaaatgggtttttttgataatgacTGA agattcgtaattattTTTGCTATACTGACAGAGACattgataaagaaagggcggcaga t" /listShort="yfhB, yfhC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 872149..872168 /Source="Nicolas_upshift_promotors" /id="U644" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.945054945054945" /psig="0.999000999001" /xcortree=2943 /SigmaFactorBS="attttcttaaaaaagaaaatgggtttttttgataatgacTGA agattcgtaattattTTTGCTATACTGACAGAGACattgataaagaaagggcggcaga t" /listShort="yfhB, yfhC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 872152 /Source="Nicolas_upshifts" /id="U644" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.945054945054945" /psig="0.999000999001" /xcortree=2943 /SigmaFactorBS="attttcttaaaaaagaaaatgggtttttttgataatgacTGA agattcgtaattattTTTGCTATACTGACAGAGACattgataaagaaagggcggcaga t" /listShort="yfhB, yfhC" /GFF_Attribute="listLong" /label="upshifts" CDS 872195..873076 /gene="yfhB" /locus_tag="BSU_08470" /old_locus_tag="BSU08470" /EC_number="5.1.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative isomerase" /protein_id="NP_388728.1" /db_xref="EnsemblGenomes-Gn:BSU08470" /db_xref="EnsemblGenomes-Tr:CAB12676" /db_xref="GOA:O31570" /db_xref="InterPro:IPR003719" /db_xref="SubtiList:BG12877" /db_xref="UniProtKB/Swiss-Prot:O31570" /translation="MKEAEVLKYEAFTSSPGKGNPAGVVLQGDDYTEDEMQIIAERAG YSETSFIRKSESADLELRYFTPGHEMNLCGHATVASLYALCEKGMLESGKTYSIQTKA GILPVKISEKDGRIHITLEQASPQFKPFTGDRKKLADALGITDEDFHEDLPIVFGSTG IWTAIVPLKSLEASKKMVPDNKQFPEVLVDLPKASVHPFTFETVHPDSDLHGRHFSSP YSGTIEDPVTGTASGVMGAYMKHYGNAEQHKFIIEQGQEIGKDGKVEIEMNEAGGHVK VNMTGTAVYSETRILKI*" /label="yfhB CDS" gene 872195..873076 /gene="yfhB" /locus_tag="BSU_08470" /old_locus_tag="BSU08470" /label="yfhB gene" promotor_-35 873087..873094 /Source="Nicolas_upshift_promotors" /id="U645" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.719280719280719" /psig="0.998001998001998" /xcortree=2110 /SigmaFactorBS="cgtattcttaaaatctaatacggatgatGGTTTACAaaaaga tgcactttcCGTTATCATTATGAAATGATaatcattttcaattgcataggaaggtgag a" /listShort="yfhC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 873110..873129 /Source="Nicolas_upshift_promotors" /id="U645" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.719280719280719" /psig="0.998001998001998" /xcortree=2110 /SigmaFactorBS="cgtattcttaaaatctaatacggatgatGGTTTACAaaaaga tgcactttcCGTTATCATTATGAAATGATaatcattttcaattgcataggaaggtgag a" /listShort="yfhC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 873119 /Source="Nicolas_upshifts" /id="U645" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.719280719280719" /psig="0.998001998001998" /xcortree=2110 /SigmaFactorBS="cgtattcttaaaatctaatacggatgatGGTTTACAaaaaga tgcactttcCGTTATCATTATGAAATGATaatcattttcaattgcataggaaggtgag a" /listShort="yfhC" /GFF_Attribute="listLong" /label="upshifts" CDS 873164..873748 /gene="yfhC" /locus_tag="BSU_08480" /old_locus_tag="BSU08480" /EC_number="1.6.99.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12354229, 22287527; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase (nitroreductase family)" /protein_id="NP_388729.1" /db_xref="EnsemblGenomes-Gn:BSU08480" /db_xref="EnsemblGenomes-Tr:CAB12677" /db_xref="GOA:O31571" /db_xref="InterPro:IPR000415" /db_xref="InterPro:IPR026021" /db_xref="InterPro:IPR029479" /db_xref="SubtiList:BG12878" /db_xref="UniProtKB/Swiss-Prot:O31571" /translation="MPQTEQIHQHSVLRDIIRSRRSIRKFKQEPVPSAVILDMLETAK YAPNHRVTEPWRFIYVSSETGKANLINTFAAFSKKSKPDMTEEKLQNFKNTLGRVPGF LLVVFQEDENERARDDDFAATSSLIQNLQLLAWEKGIGMVWKSGKILYDKEVHQAFGL QDNERFAAIIQTGYPDEAPEVKKRTPIRDRFTEM*" /label="yfhC CDS" gene 873164..873748 /gene="yfhC" /locus_tag="BSU_08480" /old_locus_tag="BSU08480" /label="yfhC gene" downshifts 873735 /Source="Nicolas_upshifts" /id="D422" /incds=0 /nref=208 /ntot=262 /MaxReadThrough="3.27483" /MaxDrop="6.40857" /score="21.7703837" /energy="-18.2" /TU="U645" /idTUdmin="U644" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(873787..873978) /gene="yfhD" /locus_tag="BSU_08490" /old_locus_tag="BSU08490" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388730.1" /db_xref="EnsemblGenomes-Gn:BSU08490" /db_xref="EnsemblGenomes-Tr:CAB12678" /db_xref="InterPro:IPR025435" /db_xref="SubtiList:BG12879" /db_xref="UniProtKB/Swiss-Prot:O31572" /translation="MGRNHIHKNRDKNKQKLPQVPDALKRETDGVYEEYSTELADADD REAQERAKAADNRAKKKSR*" /label="yfhD CDS" gene complement(873787..873978) /gene="yfhD" /locus_tag="BSU_08490" /old_locus_tag="BSU08490" /label="yfhD gene" downshifts complement(873805) /Source="Nicolas_upshifts" /id="D423" /incds=0 /nref=65 /ntot=197 /MaxReadThrough="0.436919999999999" /MaxDrop="8.51174" /score="30.1998663" /energy="-18.2" /TU="NA" /idTUdmin="U649" /TUdmin=7 /isTUend="TRUE" /label="downshifts" upshifts complement(874010) /Source="Nicolas_upshifts" /id="U646" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=840 /SigmaFactorBS="cggaaaaagctgctaagcggaagtaGGAATACatagcccctt aaaaCCAAATACTATAtttgtttgatatcactttttagggggaatttgatatgggcag a" /listShort="yfhD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(874013..874024) /Source="Nicolas_upshift_promotors" /id="U646" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=840 /SigmaFactorBS="cggaaaaagctgctaagcggaagtaGGAATACatagcccctt aaaaCCAAATACTATAtttgtttgatatcactttttagggggaatttgatatgggcag a" /listShort="yfhD" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(874039..874045) /Source="Nicolas_upshift_promotors" /id="U646" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=840 /SigmaFactorBS="cggaaaaagctgctaagcggaagtaGGAATACatagcccctt aaaaCCAAATACTATAtttgtttgatatcactttttagggggaatttgatatgggcag a" /listShort="yfhD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(874045..874155) /gene="yfhE" /locus_tag="BSU_08500" /old_locus_tag="BSU08500" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388731.1" /db_xref="EnsemblGenomes-Gn:BSU08500" /db_xref="EnsemblGenomes-Tr:CAB12679" /db_xref="InterPro:IPR025437" /db_xref="SubtiList:BG12880" /db_xref="UniProtKB/Swiss-Prot:O31573" /translation="MEKKREKHQQGANLKKMQEVLYSGEFKKAEKAAKRK*" /label="yfhE CDS" gene complement(874045..874155) /gene="yfhE" /locus_tag="BSU_08500" /old_locus_tag="BSU08500" /label="yfhE gene" promotor_-10 complement(874184..874195) /Source="Nicolas_upshift_promotors" /id="U647" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1140 /SigmaFactorBS="actctcacagctgatagcggaccgaaagacTGTATAAaaaca gcaggaagcGTCAACCTTAAGaataacatggttgaaggaggtcctttttatggaaaaa a" /listShort="yfhE, yfhD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(874186) /Source="Nicolas_upshifts" /id="U647" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1140 /SigmaFactorBS="actctcacagctgatagcggaccgaaagacTGTATAAaaaca gcaggaagcGTCAACCTTAAGaataacatggttgaaggaggtcctttttatggaaaaa a" /listShort="yfhE, yfhD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(874210..874216) /Source="Nicolas_upshift_promotors" /id="U647" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1140 /SigmaFactorBS="actctcacagctgatagcggaccgaaagacTGTATAAaaaca gcaggaagcGTCAACCTTAAGaataacatggttgaaggaggtcctttttatggaaaaa a" /listShort="yfhE, yfhD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(874210..875121) /gene="yfhF" /locus_tag="BSU_08510" /old_locus_tag="BSU08510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative nucleotide-or NAD-binding protein" /protein_id="NP_388732.1" /db_xref="EnsemblGenomes-Gn:BSU08510" /db_xref="EnsemblGenomes-Tr:CAB12680" /db_xref="GOA:O31574" /db_xref="InterPro:IPR001509" /db_xref="InterPro:IPR010099" /db_xref="InterPro:IPR013549" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12881" /db_xref="UniProtKB/Swiss-Prot:O31574" /translation="MNIAMTGGTGFLGQHLTGVLTRQGHHVYILSRNARETEQKNMTY VQWLSEGAAPEQELPHIDVWINLAGKSIFGRWTEKTKQHILSSRINATREVQRLIQKQ KEKPKTLIQASAVGIYGTSLEKTFTEDSATSDEDFLSHTAHLWEKEGQHIEAMGIRTV YARFGVMLGEKGALPLMILPYKFLAGGTIGTGRQWLSWIHVEDAAQMIRYAVENAGIS GPMNVTAPNPVDMKQFGKTIARVKHRPHWLPVPEFFLSKALGEMSLLIVKGQRALPKK AITSGFRFTYSDLEFALSQLIADRKTV*" /label="yfhF CDS" gene complement(874210..875121) /gene="yfhF" /locus_tag="BSU_08510" /old_locus_tag="BSU08510" /label="yfhF gene" promotor_-35 875007..875010 /Source="Nicolas_upshift_promotors" /id="U648" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.531468531468531" /psig="0.999000999001" /xcortree=2741 /SigmaFactorBS="acagccattggacatatgtcatatttttttGTTCagtttccc ttgcgtttCTTGATAAAATATAAACATGgtgtccctggcgggtaagaacgcctgtcag a" /listShort="S288, recX, yfhH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 875027..875046 /Source="Nicolas_upshift_promotors" /id="U648" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.531468531468531" /psig="0.999000999001" /xcortree=2741 /SigmaFactorBS="acagccattggacatatgtcatatttttttGTTCagtttccc ttgcgtttCTTGATAAAATATAAACATGgtgtccctggcgggtaagaacgcctgtcag a" /listShort="S288, recX, yfhH" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 875037..875209 /Source="Nicolas_S_feature" /locus_tag="new_925460_925632" /HighExp="LBGstat, Lbtran, T1.30H, T2.0H, T2.30H, M9-stat, T1.0H, T3.0H, Sw, G180" /AntisenseName="yfhF" /AntisenseCor="-5.3501479327985699E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S288" upshifts 875037 /Source="Nicolas_upshifts" /id="U648" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.531468531468531" /psig="0.999000999001" /xcortree=2741 /SigmaFactorBS="acagccattggacatatgtcatatttttttGTTCagtttccc ttgcgtttCTTGATAAAATATAAACATGgtgtccctggcgggtaagaacgcctgtcag a" /listShort="S288, recX, yfhH" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(875143..875161) /Source="Nicolas_upshift_promotors" /id="U649" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=135 /SigmaFactorBS="aacggcatcttaatctcccttctcaggcctgaaacgCGTTTT CttttattacaatgAGGTAAAGTATATTTATTAgaacgatgaggagagatgttcatga a" /listShort="yfhF, yfhE, yfhD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(875157) /Source="Nicolas_upshifts" /id="U649" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=135 /SigmaFactorBS="aacggcatcttaatctcccttctcaggcctgaaacgCGTTTT CttttattacaatgAGGTAAAGTATATTTATTAgaacgatgaggagagatgttcatga a" /listShort="yfhF, yfhE, yfhD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(875175..875181) /Source="Nicolas_upshift_promotors" /id="U649" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=135 /SigmaFactorBS="aacggcatcttaatctcccttctcaggcctgaaacgCGTTTT CttttattacaatgAGGTAAAGTATATTTATTAgaacgatgaggagagatgttcatga a" /listShort="yfhF, yfhE, yfhD" /GFF_Attribute="listLong" /label="promotor_-35" CDS 875210..876004 /gene="recX" /locus_tag="BSU_08520" /old_locus_tag="BSU08520" /function="16.3: Control" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:8946165, 10869079, 12547390, 23284295, 24285298" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8946165, 10869079, 12547390, 23284295, 24285298; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulatory protein RecX" /protein_id="NP_388733.1" /db_xref="EnsemblGenomes-Gn:BSU08520" /db_xref="EnsemblGenomes-Tr:CAB12681" /db_xref="GOA:O31575" /db_xref="InterPro:IPR003783" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12882" /db_xref="UniProtKB/Swiss-Prot:O31575" /translation="MPFITKISTQKKNTERFNIFLDDKYAFSVDADVLVKFELKKGKE LDDLDIIEIQYGDEVKKGFNRALDFLSYRMRSTKEVEDHLKKKETSPPVIAEVIHRLN DYKYLNDQEFAAAYVSTHKKTNGKGPDVLFRELRAKGIDDDTIKEALSSFSFEDQTRE AVKHVEKLLKKDKKLSTKELKQRAQLQLQRKGFSFDVISAAMDQIEYENDEDTEKEAL RLHAEKAFRKYRYDGSYESAMKVKQFLFRKGFSLDLIEQLLQEEEY*" /label="recX CDS" gene 875210..876004 /gene="recX" /locus_tag="BSU_08520" /old_locus_tag="BSU08520" /label="recX gene" CDS 876006..876320 /gene="yfhH" /locus_tag="BSU_08530" /old_locus_tag="BSU08530" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388734.1" /db_xref="EnsemblGenomes-Gn:BSU08530" /db_xref="EnsemblGenomes-Tr:CAB12682" /db_xref="InterPro:IPR014938" /db_xref="InterPro:IPR036289" /db_xref="PDB:1SF9" /db_xref="SubtiList:BG12883" /db_xref="UniProtKB/Swiss-Prot:O31576" /translation="MEKRYSQMTPHELNTEIALLSEKARKAEQHGIINELAVLERKIT MAKAYLLNPEDYSPGETYRVENTEDEFTISYLNGVFAWGYRTSSPQQEEALPISVLQE KE*" /label="yfhH CDS" gene 876006..876320 /gene="yfhH" /locus_tag="BSU_08530" /old_locus_tag="BSU08530" /label="yfhH gene" S_feature complement(876228..876496) /Source="Nicolas_S_feature" /locus_tag="new_926651_926919_c" /HighExp="S8, S6, S5, S7, C30, S4, nit, ferm, BT, G135" /AntisenseName="yfhH" /AntisenseCor="-0.53569713251514905" /AntisenseRegPval="-20.7" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S289" downshifts 876310 /Source="Nicolas_upshifts" /id="D424" /incds=0 /nref=71 /ntot=206 /MaxReadThrough="2.93348" /MaxDrop="5.2859" /score="24.7235138" /energy="-11.6" /TU="NA" /idTUdmin="U648" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 876394..876399 /Source="Nicolas_upshift_promotors" /id="U650" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.460539460539461" /psig=1 /xcortree=2471 /SigmaFactorBS="cagcacatttacacgaattcttaaagaaaaaatcATTGAAtt cacttgaaaaatcTTTTAAGATGAAACTCGTTGttttttaaaatcaaaggaggcgatg a" /listShort="yfhI, S290, S291, yfhJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 876415..876434 /Source="Nicolas_upshift_promotors" /id="U650" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.460539460539461" /psig=1 /xcortree=2471 /SigmaFactorBS="cagcacatttacacgaattcttaaagaaaaaatcATTGAAtt cacttgaaaaatcTTTTAAGATGAAACTCGTTGttttttaaaatcaaaggaggcgatg a" /listShort="yfhI, S290, S291, yfhJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 876420 /Source="Nicolas_upshifts" /id="U650" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.460539460539461" /psig=1 /xcortree=2471 /SigmaFactorBS="cagcacatttacacgaattcttaaagaaaaaatcATTGAAtt cacttgaaaaatcTTTTAAGATGAAACTCGTTGttttttaaaatcaaaggaggcgatg a" /listShort="yfhI, S290, S291, yfhJ" /GFF_Attribute="listLong" /label="upshifts" CDS 876463..877656 /gene="yfhI" /locus_tag="BSU_08540" /old_locus_tag="BSU08540" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22226636; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388735.1" /db_xref="EnsemblGenomes-Gn:BSU08540" /db_xref="EnsemblGenomes-Tr:CAB12683" /db_xref="GOA:O31577" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12884" /db_xref="UniProtKB/Swiss-Prot:O31577" /translation="MSIKNPSVKFIIFVLMICTFSIGYTEYAVMGILTSIANDFHIQV SSAGLLVTAYAASVCLTGPLVTIISVKLPRKPVLLGLMAIFILSNLMSALAPNFAVLA ISRILSASIHGAFFAIAMVFASEMVPPEKRAAAAASMNGGLTVALMLGVPFGSYLGDV LNWRAVFSIITALGVIGFLGLMAAVPNRKPKVIPMLMNEWGVFKHKQVLFSFAITILG YSGVFIAYTFIEPILRHSAGFSTVGITGALFAYGLGGVAGNFFAGKVPLPLLTRTMIG VMIGLIGVLAVFPYIAIYPAAAIVATFLFGACAFGTPPLLQTKVISSSEGGTTIAAAV SVSAFNLANALGAWIGGMILNGTGSYSWLFAGGALMTACGLVLSTFAHLSEKKSVYEY QVNKG*" /label="yfhI CDS" gene 876463..877656 /gene="yfhI" /locus_tag="BSU_08540" /old_locus_tag="BSU08540" /label="yfhI gene" S_feature 877657..877891 /Source="Nicolas_S_feature" /locus_tag="new_928080_928314" /HighExp="G180, Paraq, C30, Oxctl, H2O2, G135, G150, S8, Heat, LBGstat" /AntisenseName="sspK" /AntisenseCor="1.9886505145521101E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S290" CDS complement(877689..877841) /gene="sspK" /locus_tag="BSU_08550" /old_locus_tag="BSU08550" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10806362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10806362; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="YP_054573.1" /db_xref="EnsemblGenomes-Gn:BSU08550" /db_xref="EnsemblGenomes-Tr:CAE01449" /db_xref="GOA:Q7WY75" /db_xref="InterPro:IPR012611" /db_xref="SubtiList:BG14175" /db_xref="UniProtKB/Swiss-Prot:Q7WY75" /translation="MVRNKEKGFPYENENKFQGEPRAKDDYASKRADGSINQHPQERM RASGKR*" /label="sspK CDS" gene complement(877689..877841) /gene="sspK" /locus_tag="BSU_08550" /old_locus_tag="BSU08550" /label="sspK gene" downshifts complement(877706) /Source="Nicolas_upshifts" /id="D425" /incds=0 /nref=24 /ntot=45 /MaxReadThrough="2.36419" /MaxDrop="4.9889" /score="20.2715496" /energy="-12.3" /TU="NA" /idTUdmin="U652" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 877870..877877 /Source="Nicolas_upshift_promotors" /id="U651" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.924075924075924" /psig="0.995004995004995" /xcortree=2031 /SigmaFactorBS="tcggaccatgtcatatccccctaggttcgagatcaaaAAGTT GCGtcttttcagatgaAGACGTAAGGTTAGTATATGgagaacaccacgtaataaagcg t" /listShort="S291, yfhJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 877891..877910 /Source="Nicolas_upshift_promotors" /id="U651" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.924075924075924" /psig="0.995004995004995" /xcortree=2031 /SigmaFactorBS="tcggaccatgtcatatccccctaggttcgagatcaaaAAGTT GCGtcttttcagatgaAGACGTAAGGTTAGTATATGgagaacaccacgtaataaagcg t" /listShort="S291, yfhJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 877893..877965 /Source="Nicolas_S_feature" /locus_tag="new_928316_928388" /HighExp="dia5, LPhT, Diami, dia15, Etha, T0.30H, H2O2, LBGstat, BC, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.995, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S291" upshifts 877893 /Source="Nicolas_upshifts" /id="U651" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.924075924075924" /psig="0.995004995004995" /xcortree=2031 /SigmaFactorBS="tcggaccatgtcatatccccctaggttcgagatcaaaAAGTT GCGtcttttcagatgaAGACGTAAGGTTAGTATATGgagaacaccacgtaataaagcg t" /listShort="S291, yfhJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(877900..877911) /Source="Nicolas_upshift_promotors" /id="U652" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=867 /SigmaFactorBS="ttcatgtgtgcagtctcctttcttcaggaaaaaaataaCGCT TTAttacgtggtgttctCCATATACTAACcttacgtcttcatctgaaaagacgcaact t" /listShort="sspK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(877910) /Source="Nicolas_upshifts" /id="U652" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=867 /SigmaFactorBS="ttcatgtgtgcagtctcctttcttcaggaaaaaaataaCGCT TTAttacgtggtgttctCCATATACTAACcttacgtcttcatctgaaaagacgcaact t" /listShort="sspK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(877926..877932) /Source="Nicolas_upshift_promotors" /id="U652" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=867 /SigmaFactorBS="ttcatgtgtgcagtctcctttcttcaggaaaaaaataaCGCT TTAttacgtggtgttctCCATATACTAACcttacgtcttcatctgaaaagacgcaact t" /listShort="sspK" /GFF_Attribute="listLong" /label="promotor_-35" CDS 877966..878235 /gene="yfhJ" /locus_tag="BSU_08560" /old_locus_tag="BSU08560" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388736.1" /db_xref="EnsemblGenomes-Gn:BSU08560" /db_xref="EnsemblGenomes-Tr:CAB12684" /db_xref="InterPro:IPR026952" /db_xref="SubtiList:BG12885" /db_xref="UniProtKB/Swiss-Prot:O31578" /translation="MNMYIEKLTNLLLEKNEMISYIQAKTWVELLWSDFEATYAKAGH AYQGEKMTEKIVTQWIENYGGQLHLFQSSRNDVNDYLNQSRGLLH*" /label="yfhJ CDS" gene 877966..878235 /gene="yfhJ" /locus_tag="BSU_08560" /old_locus_tag="BSU08560" /label="yfhJ gene" downshifts 878224 /Source="Nicolas_upshifts" /id="D426" /incds=0 /nref=62 /ntot=233 /MaxReadThrough="2.9538" /MaxDrop="5.3621" /score="19.3423239" /energy="-10.6" /TU="NA" /idTUdmin="U650" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 878313..878319 /Source="Nicolas_upshift_promotors" /id="U653" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=223 /SigmaFactorBS="ttaaaattaccttaacaggaagaaatcataaacaaaacaTGT TTCAccagcctgtcaatcaGGGAATACCACTTATATCTtgtcaaaatgcgaggaggag c" /listShort="yfhK, S292, yfhL, yfhM, S293, S294, csbB, S295, yfhO" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 878334 /Source="Nicolas_upshifts" /id="U653" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=223 /SigmaFactorBS="ttaaaattaccttaacaggaagaaatcataaacaaaacaTGT TTCAccagcctgtcaatcaGGGAATACCACTTATATCTtgtcaaaatgcgaggaggag c" /listShort="yfhK, S292, yfhL, yfhM, S293, S294, csbB, S295, yfhO" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 878335..878353 /Source="Nicolas_upshift_promotors" /id="U653" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=223 /SigmaFactorBS="ttaaaattaccttaacaggaagaaatcataaacaaaacaTGT TTCAccagcctgtcaatcaGGGAATACCACTTATATCTtgtcaaaatgcgaggaggag c" /listShort="yfhK, S292, yfhL, yfhM, S293, S294, csbB, S295, yfhO" /GFF_Attribute="listLong" /label="promotor_-10" CDS 878380..878898 /gene="yfhK" /locus_tag="BSU_08570" /old_locus_tag="BSU08570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_388737.1" /db_xref="EnsemblGenomes-Gn:BSU08570" /db_xref="EnsemblGenomes-Tr:CAB12685" /db_xref="InterPro:IPR003646" /db_xref="SubtiList:BG12886" /db_xref="UniProtKB/Swiss-Prot:O31579" /translation="MKKKQVMLALTAAAGLGLTALHSAPAAKAAPLHDISVSMPSSDT YIIKAGKLNVRTEPNHEGDILGTVSSEQKVKVDRFVNADWAQIHFKGKKAYISTHFLM KTASQAKTTKQTAFYTPTPENGKAKQLSSGTEVTILGWGFSENGGFDFTWAFVDYGGV KGYIHTKDLQMR*" /label="yfhK CDS" gene 878380..878898 /gene="yfhK" /locus_tag="BSU_08570" /old_locus_tag="BSU08570" /label="yfhK gene" S_feature 878899..878966 /Source="Nicolas_S_feature" /locus_tag="new_929322_929389" /HighExp="Etha, Sw, Salt, M9-stat, B60, B36, Gly, LoTm, BC, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S292" promotor_-35 878934..878943 /Source="Nicolas_upshift_promotors" /id="U654" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1692 /SigmaFactorBS="ccgaggcttgtctttttgcctatgcaTGAAACATTTcttctt tctgcACGTAACAATGAGAAAggagatgatgatatgacgggtttagtcggcggagggc t" /listShort="yfhL, yfhM" /listLong="S293, S294, csbB, S295, yfhO" /label="promotor_-35" promotor_-10 878955..878970 /Source="Nicolas_upshift_promotors" /id="U654" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1692 /SigmaFactorBS="ccgaggcttgtctttttgcctatgcaTGAAACATTTcttctt tctgcACGTAACAATGAGAAAggagatgatgatatgacgggtttagtcggcggagggc t" /listShort="yfhL, yfhM" /listLong="S293, S294, csbB, S295, yfhO" /label="promotor_-10" upshifts 878968 /Source="Nicolas_upshifts" /id="U654" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1692 /SigmaFactorBS="ccgaggcttgtctttttgcctatgcaTGAAACATTTcttctt tctgcACGTAACAATGAGAAAggagatgatgatatgacgggtttagtcggcggagggc t" /listShort="yfhL, yfhM" /listLong="S293, S294, csbB, S295, yfhO" /label="upshifts" CDS 878983..879315 /gene="spdL" /locus_tag="BSU_08580" /old_locus_tag="BSU08580" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16629676, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16629676, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor for peptide SdpC immunity" /protein_id="NP_388738.1" /db_xref="EnsemblGenomes-Gn:BSU08580" /db_xref="EnsemblGenomes-Tr:CAB12686" /db_xref="GOA:O31580" /db_xref="InterPro:IPR025962" /db_xref="SubtiList:BG12887" /db_xref="UniProtKB/Swiss-Prot:O31580" /translation="MTGLVGGGLMIIAGILIKLFPPKSINSVYGYRTRRSMSDQRLWN EANRYSASLMILSGLVIAGMGLLLGSNLFILQLILLIAACVITFMLTEKRLKIMTHSQ GGDRSGRS*" /label="spdL CDS" gene 878983..879315 /gene="spdL" /locus_tag="BSU_08580" /old_locus_tag="BSU08580" /label="spdL gene" CDS 879302..880162 /gene="ephM" /locus_tag="BSU_08590" /old_locus_tag="BSU08590" /EC_number="3.3.2.10" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16597997, 20941576" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16597997, 20941576; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="stress induced epoxide hydrolase" /protein_id="NP_388739.1" /db_xref="EnsemblGenomes-Gn:BSU08590" /db_xref="EnsemblGenomes-Tr:CAB12687" /db_xref="GOA:O31581" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR000639" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12888" /db_xref="UniProtKB/Swiss-Prot:O31581" /translation="MDGVKCQFVNTNGITLHVAAAGREDGPLIVLLHGFPEFWYGWKN QIKPLVDAGYRVIAPDQRGYNLSDKPEGIDSYRIDTLRDDIIGLITQFTDEKAIVIGH DWGGAVAWHLASTRPEYLEKLIAINIPHPHVMKTVTPLYPPQWLKSSYIAYFQLPDIP EASLRENDYDTLDKAIGLSDRPALFTSEDVSRYKEAWKQPGALTAMLNWYRALRKGSL AEKPSYETVPYRMIWGMEDRFLSRKLAKETERHCPNGHLIFVDEASHWINHEKPAIVN QLILEYLKNQ*" /label="ephM CDS" gene 879302..880162 /gene="ephM" /locus_tag="BSU_08590" /old_locus_tag="BSU08590" /label="ephM gene" downshifts 880160 /Source="Nicolas_upshifts" /id="D427" /incds=0 /nref=27 /ntot=191 /MaxReadThrough="5.0793" /MaxDrop="4.1326" /score="3.7712168" /energy="-8.4" /TU="U653,U654" /idTUdmin="U654" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" promotor_-35 880220..880226 /Source="Nicolas_upshift_promotors" /id="U655" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=945 /SigmaFactorBS="tcataatggcagactttttctgtgcgttttttTTCATAGtct gttttaaacaTGACAAAATAACattaaaaatcatgaatgtcaccataaaattgtaaca a" /listShort="S293, S294, csbB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 880240..880251 /Source="Nicolas_upshift_promotors" /id="U655" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=945 /SigmaFactorBS="tcataatggcagactttttctgtgcgttttttTTCATAGtct gttttaaacaTGACAAAATAACattaaaaatcatgaatgtcaccataaaattgtaaca a" /listShort="S293, S294, csbB" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 880248..880312 /Source="Nicolas_S_feature" /locus_tag="new_930671_930735" /HighExp="Etha, S5, M9-stat, T0.30H, Sw, T-0.40H, B60, S8, B36, T1.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigB" /TUshortPSig="0.99, 1" /TUlongSig="SigWXY" /TUlongPSig=1 /label="S293" upshifts 880248 /Source="Nicolas_upshifts" /id="U655" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=945 /SigmaFactorBS="tcataatggcagactttttctgtgcgttttttTTCATAGtct gttttaaacaTGACAAAATAACattaaaaatcatgaatgtcaccataaaattgtaaca a" /listShort="S293, S294, csbB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(880270..880289) /Source="Nicolas_upshift_promotors" /id="U656" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.446553446553447" /psig="0.97902097902098" /xcortree=2407 /SigmaFactorBS="caaatcttcagtaaggctattcctttttttaaagtCGtttaa acctgtttTTTGTTACAATTTTATGGTGacattcatgatttttaatgttattttgtca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(880279) /Source="Nicolas_upshifts" /id="U656" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.446553446553447" /psig="0.97902097902098" /xcortree=2407 /SigmaFactorBS="caaatcttcagtaaggctattcctttttttaaagtCGtttaa acctgtttTTTGTTACAATTTTATGGTGacattcatgatttttaatgttattttgtca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 880295..880301 /Source="Nicolas_upshift_promotors" /id="U657" /multdbtbs="SigB,SigX" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=124 /SigmaFactorBS="taaaaatcatgaatgtcaccataaaattgtaacaaaaaacaG GTTTAAacgactttaaaaaaAGGAATAGCCTTACTGAAGatttgtgtaaaactcccct a" /listShort="S294, csbB, S295, yfhO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(880303..880304) /Source="Nicolas_upshift_promotors" /id="U656" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.446553446553447" /psig="0.97902097902098" /xcortree=2407 /SigmaFactorBS="caaatcttcagtaaggctattcctttttttaaagtCGtttaa acctgtttTTTGTTACAATTTTATGGTGacattcatgatttttaatgttattttgtca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 880314..880394 /Source="Nicolas_S_feature" /locus_tag="new_930737_930817" /HighExp="M9-stat, LBGexp, Lbexp, T0.30H, dia0, T1.30H, T1.0H, LBGtran, Paraq, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigGF, SigB" /TUshortPSig="1, 0.99, 1" /TUlongSig="SigWXY" /TUlongPSig=1 /label="S294" upshifts 880314 /Source="Nicolas_upshifts" /id="U657" /multdbtbs="SigB,SigX" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=124 /SigmaFactorBS="taaaaatcatgaatgtcaccataaaattgtaacaaaaaacaG GTTTAAacgactttaaaaaaAGGAATAGCCTTACTGAAGatttgtgtaaaactcccct a" /listShort="S294, csbB, S295, yfhO" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 880316..880334 /Source="Nicolas_upshift_promotors" /id="U657" /multdbtbs="SigB,SigX" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=124 /SigmaFactorBS="taaaaatcatgaatgtcaccataaaattgtaacaaaaaacaG GTTTAAacgactttaaaaaaAGGAATAGCCTTACTGAAGatttgtgtaaaactcccct a" /listShort="S294, csbB, S295, yfhO" /GFF_Attribute="listLong" /label="promotor_-10" CDS 880395..881384 /gene="csbB" /locus_tag="BSU_08600" /old_locus_tag="BSU08600" /EC_number="2.4.-.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8921856, 9636707, 23632331; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative bactoprenol glycosyl transferase, phageorigin" /protein_id="NP_388740.1" /db_xref="EnsemblGenomes-Gn:BSU08600" /db_xref="EnsemblGenomes-Tr:CAB12688" /db_xref="GOA:Q45539" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG11834" /db_xref="UniProtKB/Swiss-Prot:Q45539" /translation="MKQGLISIIIPSYNEGYNVKLIHESLKKEFKNIHYDYEIFFIND GSVDDTLQQIKDLAATCSRVKYISFSRNFGKEAAILAGFEHVQGEAVIVMDADLQHPT YLLKEFIKGYEEGYDQVIAQRNRKGDSFVRSLLSSMYYKFINKAVEVDLRDGVGDFRL LSRQAVNALLKLSEGNRFSKGLFCWIGFDQKIVFYENVERKNGTSKWSFSSLFNYGMD GVVSFNHKPLRLCFYTGIFILLLSIIYIIATFVKILTNGISVPGYFTIISAVLFLGGV QLLSLGIIGEYIGRIYYETKKRPHYLIKEANIPNKDLPETNELKSMRRLTKMH*" /label="csbB CDS" gene 880395..881384 /gene="csbB" /locus_tag="BSU_08600" /old_locus_tag="BSU08600" /label="csbB gene" upshifts complement(880544) /Source="Nicolas_upshifts" /id="U658" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.712287712287712" /psig="0.037962037962038" /xcortree=125 /SigmaFactorBS="agaaaaagatatatattttacccggctgcaCGTCGctgccaa gtctttgatCTGCTgaagcgtgtcatcaacacttccgtcgtttatgaagaatatttca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(880549..880553) /Source="Nicolas_upshift_promotors" /id="U658" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.712287712287712" /psig="0.037962037962038" /xcortree=125 /SigmaFactorBS="agaaaaagatatatattttacccggctgcaCGTCGctgccaa gtctttgatCTGCTgaagcgtgtcatcaacacttccgtcgtttatgaagaatatttca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(880570..880574) /Source="Nicolas_upshift_promotors" /id="U658" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.712287712287712" /psig="0.037962037962038" /xcortree=125 /SigmaFactorBS="agaaaaagatatatattttacccggctgcaCGTCGctgccaa gtctttgatCTGCTgaagcgtgtcatcaacacttccgtcgtttatgaagaatatttca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 881385..881455 /Source="Nicolas_S_feature" /locus_tag="new_931808_931878" /HighExp="LPhT, Heat, Etha, LBGexp, M9-stat, LBGtran, Lbexp, Sw, dia0, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigB" /TUshortPSig="1, 1" /TUlongSig="SigWXY" /TUlongPSig=1 /label="S295" CDS 881456..884041 /gene="yfhO" /locus_tag="BSU_08610" /old_locus_tag="BSU08610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23632331; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="conserved membrane protein" /protein_id="NP_388741.2" /db_xref="EnsemblGenomes-Gn:BSU08610" /db_xref="EnsemblGenomes-Tr:CAB12689" /db_xref="GOA:O31582" /db_xref="InterPro:IPR018580" /db_xref="SubtiList:BG12889" /db_xref="UniProtKB/Swiss-Prot:O31582" /translation="MKRKHIMIYAASLLVSVLAHAFFVKEWAEGRYMTGPGDGLAQMI VFKKLLFDQYTHGNFFYNYSFGLGGGTFSQLGYYFSASFLFLAVSAAVWLLQAVQLIG ETDTLFWAESAVFISIFKLSLIIFTSASVFHYLLKHRAASFTGAVLYGVSIIYFRHEA YWEFFTDTMVWLPLLVLGAEKIIRERRPAWFIVACSLTLINNFYFAYINLIFIGIYVL FRWLIRLEPHEEKRWIQIRLFLVSGFISFGISAAAFVPVVYGFLNNLRPPYSQKIEWL NFDDNILFSSRIIIVPAAFLLFLFIISFYKNRVFRLFAGLSLLFILFHFSPYAASVFN GFSAPQNRFEYVLAFTIAGAAAAGLSQLSELKRKELLPAAAVVLLLYLYHIQRYKLDI WKPANESILLLLLMTIAALFAAAFAKKRAKMAVYGIIILSSLFVANSYQKYALSEGGD LDSVTKEYLTSEEYRGRESSELIRRLQKEDDDPLMRIDWMNGVRNNTPIIYGFNGFSA YSSILNKDLLAFYWNDLSIDMGRESVSRYASLGDRANLYSLLYGKYYMTEKTNEASVP YGFKKHLETEHYAVYENQYMLPFVKTADAIYSESELDRLPALAKEQAMLKGIILKDPS GKTEQTPKPSNLITKSDITAKQAQYQNGLLTVTGENGGELIITPKQPSSAPGDYYVSF YLKSKAKDKGFTLKVNDYVTTRKSNKSIYKTGVNNITVRVPKSGHISINLPKGTYELR NIALYEENYQTLKNAVMQNKTEKADKLNWNKNRLTFSYHLSKDQYIMLPIPYEKGWEL KINGKTQKIEKADYAFIGFKAQKGDNHIELTYYPPYFKISAIISLVSLLLAVFYIRRK KPGSI*" /label="yfhO CDS" gene 881456..884041 /gene="yfhO" /locus_tag="BSU_08610" /old_locus_tag="BSU08610" /label="yfhO gene" downshifts 884010 /Source="Nicolas_upshifts" /id="D428" /incds=0 /nref=63 /ntot=217 /MaxReadThrough="2.13267" /MaxDrop="4.17784" /score="2.41489488" /energy="-13.3" /TU="NA" /idTUdmin="U657" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(884034..885017) /gene="yfhP" /locus_tag="BSU_08620" /old_locus_tag="BSU08620" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10463184, 10524235, 15849754, 16850406, 24237659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane hydrolase" /protein_id="NP_388742.1" /db_xref="EnsemblGenomes-Gn:BSU08620" /db_xref="EnsemblGenomes-Tr:CAB12690" /db_xref="GOA:O31583" /db_xref="InterPro:IPR007404" /db_xref="SubtiList:BG12890" /db_xref="UniProtKB/Swiss-Prot:O31583" /translation="MDTGTHVVMGIALGGIATLDPVVGSDPAMAHAVMIATLAGSQAP DIDTVLKLKNNAVYIRNHRGFTHSIPAVLFWSVIIPAILYLFYPQADFLHLWLWTLLA VVLHVFVDIFNAYGTQAIRPFSKKWVALGLINTFDPFIFISHLAAIAIWYAGGSPGIT FLSLYIILVGYYLVRLIMQLRIKRKLHEMIHDEIESIIISPTMKFRQWRIAVTTAHAF YVGRSMEGHVVILDTFNRVPVPETDVMHAAKQDDNIAAFLSFSPVYRWEVDTFKDHYE VRFIDLRYRSKGHYPFVAIVHIGHDLTIRSSYTGWIFSEEKLQKKLKLGSI*" /label="yfhP CDS" gene complement(884034..885017) /gene="yfhP" /locus_tag="BSU_08620" /old_locus_tag="BSU08620" /label="yfhP gene" downshifts complement(884068) /Source="Nicolas_upshifts" /id="D429" /incds=0 /nref=28 /ntot=200 /MaxReadThrough="2.65266" /MaxDrop="4.43244" /score="25.5564412" /energy="-17.5" /TU="NA" /idTUdmin="U661" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" promotor_-35 884491..884500 /Source="Nicolas_upshift_promotors" /id="U659" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1381 /SigmaFactorBS="atgaagcttccgtttaattctcagctgcatgatcAGGCGCAC CAagtagtagcctaCCAATATGATATATAAGCTGagaaacgtgatgccgggactcccg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 884513..884532 /Source="Nicolas_upshift_promotors" /id="U659" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1381 /SigmaFactorBS="atgaagcttccgtttaattctcagctgcatgatcAGGCGCAC CAagtagtagcctaCCAATATGATATATAAGCTGagaaacgtgatgccgggactcccg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 884517 /Source="Nicolas_upshifts" /id="U659" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1381 /SigmaFactorBS="atgaagcttccgtttaattctcagctgcatgatcAGGCGCAC CAagtagtagcctaCCAATATGATATATAAGCTGagaaacgtgatgccgggactcccg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(885018..885165) /Source="Nicolas_S_feature" /locus_tag="new_935441_935588_c" /HighExp="Diami, dia15, M9-stat, dia5, Etha, H2O2, S6, Salt, Lbtran, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S296" promotor_-35 885122..885126 /Source="Nicolas_upshift_promotors" /id="U660" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.718281718281718" /psig="0.998001998001998" /xcortree=2674 /SigmaFactorBS="tttaaactgattcaatcgttctcatatgtttccGCTTTttct ttattactattTAATGTAACATATTATCGTActgtgcccttagtgtacaacaaaaaac a" /listShort="S297, yfhQ, S298, fabL, sspE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 885142..885161 /Source="Nicolas_upshift_promotors" /id="U660" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.718281718281718" /psig="0.998001998001998" /xcortree=2674 /SigmaFactorBS="tttaaactgattcaatcgttctcatatgtttccGCTTTttct ttattactattTAATGTAACATATTATCGTActgtgcccttagtgtacaacaaaaaac a" /listShort="S297, yfhQ, S298, fabL, sspE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 885149 /Source="Nicolas_upshifts" /id="U660" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.718281718281718" /psig="0.998001998001998" /xcortree=2674 /SigmaFactorBS="tttaaactgattcaatcgttctcatatgtttccGCTTTttct ttattactattTAATGTAACATATTATCGTActgtgcccttagtgtacaacaaaaaac a" /listShort="S297, yfhQ, S298, fabL, sspE" /GFF_Attribute="listLong" /label="upshifts" S_feature 885155..885232 /Source="Nicolas_S_feature" /locus_tag="new_935578_935655" /HighExp="H2O2, G150, G180, LBGstat, dia15, Diami, Oxctl, Paraq, G135, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S297" promotor_-10 complement(885163..885182) /Source="Nicolas_upshift_promotors" /id="U661" /multdbtbs="SigK,SigK" /comp="M19" /sig="SigA" /pcomp="0.875124875124875" /psig="0.997002997002997" /xcortree=643 /SigmaFactorBS="tctccccagtctttcgcgcccCGCTTTTCtttagactgtttt tTGTTGTACACTAAGGGCACAgtacgataatatgttacattaaatagtaataaagaaa a" /listShort="S296, yfhP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(885165) /Source="Nicolas_upshifts" /id="U661" /multdbtbs="SigK,SigK" /comp="M19" /sig="SigA" /pcomp="0.875124875124875" /psig="0.997002997002997" /xcortree=643 /SigmaFactorBS="tctccccagtctttcgcgcccCGCTTTTCtttagactgtttt tTGTTGTACACTAAGGGCACAgtacgataatatgttacattaaatagtaataaagaaa a" /listShort="S296, yfhP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(885197..885204) /Source="Nicolas_upshift_promotors" /id="U661" /multdbtbs="SigK,SigK" /comp="M19" /sig="SigA" /pcomp="0.875124875124875" /psig="0.997002997002997" /xcortree=643 /SigmaFactorBS="tctccccagtctttcgcgcccCGCTTTTCtttagactgtttt tTGTTGTACACTAAGGGCACAgtacgataatatgttacattaaatagtaataaagaaa a" /listShort="S296, yfhP" /GFF_Attribute="listLong" /label="promotor_-35" CDS 885233..886342 /gene="mutY" /locus_tag="BSU_08630" /old_locus_tag="BSU08630" /EC_number="3.2.2.-" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10463184, 20971907, 21954439, 27399782" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10463184, 20971907, 21954439, 27399782; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="A/G-specific adenine glycosylase or DNA-(apurinic or apyrimidinic site) lyase" /protein_id="NP_388743.1" /db_xref="EnsemblGenomes-Gn:BSU08630" /db_xref="EnsemblGenomes-Tr:CAB12691" /db_xref="GOA:O31584" /db_xref="InterPro:IPR003265" /db_xref="InterPro:IPR003651" /db_xref="InterPro:IPR005760" /db_xref="InterPro:IPR011257" /db_xref="InterPro:IPR015797" /db_xref="InterPro:IPR023170" /db_xref="InterPro:IPR029119" /db_xref="SubtiList:BG12891" /db_xref="UniProtKB/Swiss-Prot:O31584" /translation="MNVLEDKLKQKDIQQFRDDLISWFEREQRVLPWREDQDPYKVWV SEVMLQQTRVETVIPYFLRFVEQFPTVEALADADEEKVLKAWEGLGYYSRVRNLQSAV KEVKQEYGGIVPPDEKDFGGLKGVGPYTKGAVLSIAYNKPIPAVDGNVMRVMSRILSI WDDIAKPKTRTIFEDAIRAFISKEKPSEFNQGLMELGALICTPKSPSCLLCPVQQHCS AFEEGTERELPVKSKKKKPGIKTMAAIVLTDEDGQVYIHKRPSKGLLANLWEFPNLET QKGIKTEREQLIAFLENEYGIQADISDLQGVVEHVFTHLVWNISVFFGKVKQVSDTSK LKKVTKEELEQFAFPVSHQKIWKMAGEAAAISAAP*" /label="mutY CDS" gene 885233..886342 /gene="mutY" /locus_tag="BSU_08630" /old_locus_tag="BSU08630" /label="mutY gene" promotor_-35 886179..886183 /Source="Nicolas_upshift_promotors" /id="U662" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.556443556443556" /psig="0.997002997002997" /xcortree=2563 /SigmaFactorBS="gtagtcgagcatgttttcacccacctggTATGGaatatttca gtgtttTTCGGTAAAGTAAAACAAGTgtcggataccagcaagctgaaaaaagtaacga a" /listShort="S298, fabL, sspE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 886199..886218 /Source="Nicolas_upshift_promotors" /id="U662" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.556443556443556" /psig="0.997002997002997" /xcortree=2563 /SigmaFactorBS="gtagtcgagcatgttttcacccacctggTATGGaatatttca gtgtttTTCGGTAAAGTAAAACAAGTgtcggataccagcaagctgaaaaaagtaacga a" /listShort="S298, fabL, sspE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 886211 /Source="Nicolas_upshifts" /id="U662" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.556443556443556" /psig="0.997002997002997" /xcortree=2563 /SigmaFactorBS="gtagtcgagcatgttttcacccacctggTATGGaatatttca gtgtttTTCGGTAAAGTAAAACAAGTgtcggataccagcaagctgaaaaaagtaacga a" /listShort="S298, fabL, sspE" /GFF_Attribute="listLong" /label="upshifts" S_feature 886343..886655 /Source="Nicolas_S_feature" /locus_tag="new_936766_937078" /HighExp="H2O2, G150, dia15, G135, G180, Oxctl, Paraq, dia0, LBGexp, Lbexp" /AntisenseName="yfhS" /AntisenseCor="-0.72611377663365595" /AntisenseRegPval="-44.6" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S298" CDS complement(886350..886574) /gene="yfhS" /locus_tag="BSU_08640" /old_locus_tag="BSU08640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 10463184" /codon_start=1 /transl_table=11 /product="conserved protein related to sporulation" /protein_id="NP_388744.1" /db_xref="EnsemblGenomes-Gn:BSU08640" /db_xref="EnsemblGenomes-Tr:CAB12692" /db_xref="SubtiList:BG12892" /db_xref="UniProtKB/Swiss-Prot:O31585" /translation="MYVGRDMSELNMVSKKDWKNSELAYFHHAFQQIMPYLNEEGQSK YRELTQEIEARGGMKRNEADYSHGTRVSYD*" /label="yfhS CDS" gene complement(886350..886574) /gene="yfhS" /locus_tag="BSU_08640" /old_locus_tag="BSU08640" /label="yfhS gene" promotor_-10 complement(886604..886615) /Source="Nicolas_upshift_promotors" /id="U663" /multdbtbs="SigE" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=858 /SigmaFactorBS="ttttgttccatttttcctcatctccttgtagCGTATAGttct tttatttccACAAACAATAATggcaagaactttaaagggggtcttctgttatgtatgt c" /listShort="yfhS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(886606) /Source="Nicolas_upshifts" /id="U663" /multdbtbs="SigE" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=858 /SigmaFactorBS="ttttgttccatttttcctcatctccttgtagCGTATAGttct tttatttccACAAACAATAATggcaagaactttaaagggggtcttctgttatgtatgt c" /listShort="yfhS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(886629..886635) /Source="Nicolas_upshift_promotors" /id="U663" /multdbtbs="SigE" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=858 /SigmaFactorBS="ttttgttccatttttcctcatctccttgtagCGTATAGttct tttatttccACAAACAATAATggcaagaactttaaagggggtcttctgttatgtatgt c" /listShort="yfhS" /GFF_Attribute="listLong" /label="promotor_-35" CDS 886656..887408 /gene="fabL" /locus_tag="BSU_08650" /old_locus_tag="BSU08650" /EC_number="1.3.1.10" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11007778, 12440970, 17329825, 21185310" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11007778, 12440970, 17329825, 21185310; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enoyl-acyl carrier protein reductase III" /protein_id="NP_388745.1" /db_xref="EnsemblGenomes-Gn:BSU08650" /db_xref="EnsemblGenomes-Tr:CAB12693" /db_xref="GOA:P71079" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="PDB:3OIC" /db_xref="PDB:3OID" /db_xref="SubtiList:BG12221" /db_xref="UniProtKB/Swiss-Prot:P71079" /translation="MEQNKCALVTGSSRGVGKAAAIRLAENGYNIVINYARSKKAALE TAEEIEKLGVKVLVVKANVGQPAKIKEMFQQIDETFGRLDVFVNNAASGVLRPVMELE ETHWDWTMNINAKALLFCAQEAAKLMEKNGGGHIVSISSLGSIRYLENYTTVGVSKAA LEALTRYLAVELSPKQIIVNAVSGGAIDTDALKHFPNREDLLEDARQNTPAGRMVEIK DMVDTVEFLVSSKADMIRGQTIIVDGGRSLLV*" /label="fabL CDS" gene 886656..887408 /gene="fabL" /locus_tag="BSU_08650" /old_locus_tag="BSU08650" /label="fabL gene" promotor_-35 887425..887431 /Source="Nicolas_upshift_promotors" /id="U664" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=800 /SigmaFactorBS="cggacgctcactgctcgtttaaaaatttttaaaaaagaGGAA TAGctatacgatcacctGCACATTCTAATgaccgtggaggtgataacaatggctaact c" /listShort="sspE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 887446..887457 /Source="Nicolas_upshift_promotors" /id="U664" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=800 /SigmaFactorBS="cggacgctcactgctcgtttaaaaatttttaaaaaagaGGAA TAGctatacgatcacctGCACATTCTAATgaccgtggaggtgataacaatggctaact c" /listShort="sspE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 887447 /Source="Nicolas_upshifts" /id="U664" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=800 /SigmaFactorBS="cggacgctcactgctcgtttaaaaatttttaaaaaagaGGAA TAGctatacgatcacctGCACATTCTAATgaccgtggaggtgataacaatggctaact c" /listShort="sspE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(887454..887468) /Source="Nicolas_upshift_promotors" /id="U665" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.841158841158841" /psig="0.022977022977023" /xcortree=711 /SigmaFactorBS="tggttttgttttctaacttgttgagcgtttgttttgctgaag ttatttgagttaGCCATtgttatcaCCTCCACGGTCATTAgaatgtgcaggtgatcgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(887475) /Source="Nicolas_upshifts" /id="U665" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.841158841158841" /psig="0.022977022977023" /xcortree=711 /SigmaFactorBS="tggttttgttttctaacttgttgagcgtttgttttgctgaag ttatttgagttaGCCATtgttatcaCCTCCACGGTCATTAgaatgtgcaggtgatcgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(887477..887481) /Source="Nicolas_upshift_promotors" /id="U665" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.841158841158841" /psig="0.022977022977023" /xcortree=711 /SigmaFactorBS="tggttttgttttctaacttgttgagcgtttgttttgctgaag ttatttgagttaGCCATtgttatcaCCTCCACGGTCATTAgaatgtgcaggtgatcgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 887477..887731 /gene="sspE" /locus_tag="BSU_08660" /old_locus_tag="BSU08660" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1744043, 7592342, 9540829, 19542328, 23314362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1744043, 7592342, 9540829, 19542328, 23314362; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein (gamma-type SASP)" /protein_id="NP_388746.1" /db_xref="EnsemblGenomes-Gn:BSU08660" /db_xref="EnsemblGenomes-Tr:CAB12694" /db_xref="GOA:P07784" /db_xref="InterPro:IPR006341" /db_xref="SubtiList:BG10789" /db_xref="UniProtKB/Swiss-Prot:P07784" /translation="MANSNNFSKTNAQQVRKQNQQSAAGQGQFGTEFASETNAQQVRK QNQQSAGQQGQFGTEFASETDAQQVRQQNQSAEQNKQQNS*" /label="sspE CDS" gene 887477..887731 /gene="sspE" /locus_tag="BSU_08660" /old_locus_tag="BSU08660" /label="sspE gene" downshifts 887729 /Source="Nicolas_upshifts" /id="D430" /incds=0 /nref=261 /ntot=269 /MaxReadThrough="1.59207" /MaxDrop="8.74804" /score="9.25353719" /energy="-9.5" /TU="NA" /idTUdmin="U660" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(887754) /Source="Nicolas_upshifts" /id="D431" /incds=0 /nref=3 /ntot=21 /MaxReadThrough="1.21036" /MaxDrop="5.14076" /score="-9.78320441" /energy="-7.1" /TU="NA" /idTUdmin="U663" /TUdmin="-1687" /isTUend="FALSE" /label="downshifts" CDS 887820..888164 /gene="ygaB" /locus_tag="BSU_08670" /old_locus_tag="BSU08670" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388747.1" /db_xref="EnsemblGenomes-Gn:BSU08670" /db_xref="EnsemblGenomes-Tr:CAB12695" /db_xref="InterPro:IPR025572" /db_xref="SubtiList:BG12222" /db_xref="UniProtKB/Swiss-Prot:P71080" /translation="MSQRVCFMEIEMIKGGNVYTFIRLKEEPMTEFEKLVSEQMKTMD KLLDLQSELDRCKQIEAELRHLERDARLRGIQAEIAVKRKHLADIQDMFQKQTEQVIR SYRSSEKPSSFV*" /label="ygaB CDS" gene 887820..888164 /gene="ygaB" /locus_tag="BSU_08670" /old_locus_tag="BSU08670" /label="ygaB gene" promotor_-35 887827..887835 /Source="Nicolas_upshift_promotors" /id="U666" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=444 /SigmaFactorBS="aaaaacgacaaaacttgtggaaggtctacagaatgagtcAAA GGGTTTgctttatggaGATCGAAATGATTAAAGGAggaaatgtttatactttcatcag g" /listShort="ygaB, S299, ygaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 887846..887864 /Source="Nicolas_upshift_promotors" /id="U666" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=444 /SigmaFactorBS="aaaaacgacaaaacttgtggaaggtctacagaatgagtcAAA GGGTTTgctttatggaGATCGAAATGATTAAAGGAggaaatgtttatactttcatcag g" /listShort="ygaB, S299, ygaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 887848 /Source="Nicolas_upshifts" /id="U666" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=444 /SigmaFactorBS="aaaaacgacaaaacttgtggaaggtctacagaatgagtcAAA GGGTTTgctttatggaGATCGAAATGATTAAAGGAggaaatgtttatactttcatcag g" /listShort="ygaB, S299, ygaC" /GFF_Attribute="listLong" /label="upshifts" downshifts 888147 /Source="Nicolas_upshifts" /id="D432" /incds=0 /nref=1 /ntot=27 /MaxReadThrough="4.84572" /MaxDrop="3.29993" /score="13.9694142" /energy="-11.5" /TU="U666" /idTUdmin="U660" /TUdmin=418 /isTUend="FALSE" /label="downshifts" promotor_-35 888203..888210 /Source="Nicolas_upshift_promotors" /id="U667" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.641358641358641" /psig=1 /xcortree=2074 /SigmaFactorBS="tgtgccattccccggccggaatggctctttTATTTTCAtttt tcaatttgtAACGTTATAATAGGTAAAAGacgttgtcggtaagcaaatttggacatac t" /listShort="S299, ygaC, ygaD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 888224..888243 /Source="Nicolas_upshift_promotors" /id="U667" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.641358641358641" /psig=1 /xcortree=2074 /SigmaFactorBS="tgtgccattccccggccggaatggctctttTATTTTCAtttt tcaatttgtAACGTTATAATAGGTAAAAGacgttgtcggtaagcaaatttggacatac t" /listShort="S299, ygaC, ygaD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 888233..888307 /Source="Nicolas_S_feature" /locus_tag="new_938656_938730" /HighExp="Etha, dia15, dia5, Diami, Salt, H2O2, BC, T5.0H, Cold, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S299" upshifts 888233 /Source="Nicolas_upshifts" /id="U667" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.641358641358641" /psig=1 /xcortree=2074 /SigmaFactorBS="tgtgccattccccggccggaatggctctttTATTTTCAtttt tcaatttgtAACGTTATAATAGGTAAAAGacgttgtcggtaagcaaatttggacatac t" /listShort="S299, ygaC, ygaD" /GFF_Attribute="listLong" /label="upshifts" CDS 888308..888838 /gene="ygaC" /locus_tag="BSU_08680" /old_locus_tag="BSU08680" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19383706, 22333191; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative RNA binding factor" /protein_id="NP_388748.3" /db_xref="EnsemblGenomes-Gn:BSU08680" /db_xref="EnsemblGenomes-Tr:CAB12696" /db_xref="InterPro:IPR007295" /db_xref="InterPro:IPR016882" /db_xref="InterPro:IPR035930" /db_xref="SubtiList:BG12223" /db_xref="UniProtKB/Swiss-Prot:Q796Z1" /translation="MGYPKEGETIQIHSYKHNGLIHRIWNETTILKSTEMCVIGANDR TMVTESDGRTWITREPAICYFHARQWFNVIGMLREDGVHYYCNISSPFAYDGEAIKYI DYDLDVKVFPDMTYNILDEDEYDDHRKAMNYPKEIDSILRDYLNTLLHWIHQRQGPFA PEFVDMWYERYLRYTK*" /label="ygaC CDS" gene 888308..888838 /gene="ygaC" /locus_tag="BSU_08680" /old_locus_tag="BSU08680" /label="ygaC gene" downshifts 888829 /Source="Nicolas_upshifts" /id="D433" /incds=0 /nref=8 /ntot=135 /MaxReadThrough="6.10669" /MaxDrop="3.97335" /score="-5.22328881" /energy="-7" /TU="U667" /idTUdmin="U666" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 888926..890668 /gene="ygaD" /locus_tag="BSU_08690" /old_locus_tag="BSU08690" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_388749.2" /db_xref="EnsemblGenomes-Gn:BSU08690" /db_xref="EnsemblGenomes-Tr:CAB12697" /db_xref="GOA:P71082" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG12224" /db_xref="UniProtKB/Swiss-Prot:P71082" /translation="MGVMKRYMQFVKPYKKQIFVTVLIGIVKFSIPLALPLLLKYVVD DIIQGGGTASDKTTSLFTIMAIMFALFLILRPPVEYYRQYFAQWTASKVLYDIRAKLF DHIQKLSLRFYANTRTGEVISRVINDVEQTKDFVITGLMNIWLDMLTILIVISIMLTL DVKLTLISIVLFPLYGISVKYFYGRLRKLTRERSQALAQVQGHLHERIQGMPVIRSFA IEDHEQAQFNEKNGHFLDKAIRHTNWNAKTFAVVNTITDLAPLIVIACAGYFVINGPL TVGTMVAFVGYIDRMYNPVRRLINSSTTLTQSIASMDRVFEFIDEPYELTDKPNAIKA DQIRGGVEFQNVSFQYEKDKENILHDVSLKVNRGETVALVGMSGGGKSTLVSLIPRFY DVTSGRLLIDGTDIRDYEARSLRNQVGMVLQDTFLFSETIRENIAIGKPDATLEEIIE AAKAANAHEFIMSFPEGYETRVGERGVKLSGGQKQRISIARVFLKNPPLLILDEATSA LDLESEHYIQEAMDKLAKDRTTFVVAHRLSTITHADKIVVMENGTIIEIGTHDELMDY ESQYKHLFTIQNLN*" /label="ygaD CDS" gene 888926..890668 /gene="ygaD" /locus_tag="BSU_08690" /old_locus_tag="BSU08690" /label="ygaD gene" downshifts 890655 /Source="Nicolas_upshifts" /id="D434" /incds=0 /nref=87 /ntot=233 /MaxReadThrough="2.54676" /MaxDrop="5.20475" /score="22.3853226" /energy="-14.1" /TU="NA" /idTUdmin="U667" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(890745..891806) /gene="ygaE" /locus_tag="BSU_08700" /old_locus_tag="BSU08700" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="NP_388750.1" /db_xref="EnsemblGenomes-Gn:BSU08700" /db_xref="EnsemblGenomes-Tr:CAB12698" /db_xref="GOA:P71083" /db_xref="InterPro:IPR010343" /db_xref="SubtiList:BG12225" /db_xref="UniProtKB/Swiss-Prot:P71083" /translation="MKLGARIFKTGIAITLALYLASWIGLPAPIFAGIAAIFAIQPSI YRSFLIIIDQVQANIIGAVIATVFGLIFGPSPIMIGLTAVIVITIMLKLKIEHTISIA LVTVIAILESAGDDFLMFALIRTSTVILGVLSSFIVNLVFLPPKYETKLIHNTVENTE EIMKWIRLSMRQSTEHSILKEDIEKLKEKMIKLDQTYLLYKEERSYFKKTTYVKSRKL VLFRQAIITANRALDTLKKLHRLENEIYHMPEEFQETLTEELDYLLYWHERILMRFVG KIKPHDDAVEEGIRYKQLLTKSFLKNQQNTDEELIDYNMLNIMASAVEYREQLEHLET LITSFQTYHPKDCEIETEE*" /label="ygaE CDS" gene complement(890745..891806) /gene="ygaE" /locus_tag="BSU_08700" /old_locus_tag="BSU08700" /label="ygaE gene" downshifts complement(890756) /Source="Nicolas_upshifts" /id="D435" /incds=0 /nref=181 /ntot=254 /MaxReadThrough="1.1413" /MaxDrop="7.13599" /score="26.0617552" /energy="-9.4" /TU="NA" /idTUdmin="U668" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" S_feature complement(891807..891897) /Source="Nicolas_S_feature" /locus_tag="new_942230_942320_c" /HighExp="G180, Oxctl, Paraq, C30, G150, LBGexp, LPhT, S4, G135, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S300" promotor_-10 complement(891895..891914) /Source="Nicolas_upshift_promotors" /id="U668" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.502497502497502" /psig="0.998001998001998" /xcortree=2441 /SigmaFactorBS="aagattttggtctttttctagaaaaataGCTTGAATatttgt atcgatccCTGTATATTACTTAATTGTTtagcaaataaactaaccgggaattttaagg a" /listShort="S300, ygaE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(891904) /Source="Nicolas_upshifts" /id="U668" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.502497502497502" /psig="0.998001998001998" /xcortree=2441 /SigmaFactorBS="aagattttggtctttttctagaaaaataGCTTGAATatttgt atcgatccCTGTATATTACTTAATTGTTtagcaaataaactaaccgggaattttaagg a" /listShort="S300, ygaE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(891929..891936) /Source="Nicolas_upshift_promotors" /id="U668" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.502497502497502" /psig="0.998001998001998" /xcortree=2441 /SigmaFactorBS="aagattttggtctttttctagaaaaataGCTTGAATatttgt atcgatccCTGTATATTACTTAATTGTTtagcaaataaactaaccgggaattttaagg a" /listShort="S300, ygaE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(892026..893315) /gene="gsaB" /locus_tag="BSU_08710" /old_locus_tag="BSU08710" /EC_number="5.4.3.8" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15231799, 19930658; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate-1-semialdehyde aminotransferase, classIII aminotransferase" /protein_id="NP_388751.3" /db_xref="EnsemblGenomes-Gn:BSU08710" /db_xref="EnsemblGenomes-Tr:CAB12699" /db_xref="GOA:P71084" /db_xref="InterPro:IPR004639" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG11943" /db_xref="UniProtKB/Swiss-Prot:P71084" /translation="MHTKSIELHNEALQHIVGGVNSPSRSYKAVGGGSPVAMEKASGA YFWDVDGNKYIDYLAAYGPIITGHAHPHITEAIKKAAENGVLYGTPTKHEVTFAKMLK EAIPAMDKVRFVNSGTEAVMTTIRVARAYTGRTKIIKFAGCYHGHSDLVLVAAGSGPS TLGTPDSAGVPKSIANEVITVPFNDIDSYKAALEKWGSEIAAVLVEPIVGNFGIVEPK EGFLEQVNELTHNAGALVIYDEVITAFRFMYGGAQDLLQVKPDLTALGKIIGGGLPIG AYGGKQEIMEQVAPLGPAYQAGTMAGNPASILSGIACLEVLKEKGVYEKLDHLGAMLE EGILKHAETHGITITVNRLKGALTVYFSDEKVENYEQAERSDGETFSTFFKLMLERGI NLAPSKYEAWFITTAHTEQDIKDTLTAVEDAFKHLKN*" /label="gsaB CDS" gene complement(892026..893315) /gene="gsaB" /locus_tag="BSU_08710" /old_locus_tag="BSU08710" /label="gsaB gene" downshifts complement(892029) /Source="Nicolas_upshifts" /id="D436" /incds=0 /nref=235 /ntot=258 /MaxReadThrough="2.54961" /MaxDrop="5.8522" /score="29.5551149" /energy="-11" /TU="NA" /idTUdmin="U669" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(893343..893362) /Source="Nicolas_upshift_promotors" /id="U669" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=1888 /SigmaFactorBS="tccagattacaaccatctcagctgaatctgaagcccgaagcc aTTGTTCttgttcggaagCATGCTACAATAGAAAGGACgcatggagatataggaggtt t" /listShort="gsaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(893362) /Source="Nicolas_upshifts" /id="U669" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=1888 /SigmaFactorBS="tccagattacaaccatctcagctgaatctgaagcccgaagcc aTTGTTCttgttcggaagCATGCTACAATAGAAAGGACgcatggagatataggaggtt t" /listShort="gsaB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(893364..894075) /Source="Nicolas_S_feature" /locus_tag="new_943787_944498_c" /HighExp="LoTm, M9-stat, B60, S8, C30, Cold, B36, T1.30H, Etha, T2.0H" /AntisenseName="ygaF" /AntisenseCor="-0.29702219161000198" /AntisenseRegPval="-6.2" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S301" promotor_-35 complement(893374..893379) /Source="Nicolas_upshift_promotors" /id="U669" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=1888 /SigmaFactorBS="tccagattacaaccatctcagctgaatctgaagcccgaagcc aTTGTTCttgttcggaagCATGCTACAATAGAAAGGACgcatggagatataggaggtt t" /listShort="gsaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 893408..893415 /Source="Nicolas_upshift_promotors" /id="U670" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig=1 /xcortree=2268 /SigmaFactorBS="aacaagaacaatggcttcgggcttcagattcagctgagaTGG TTGTAatctggacaagaaTTGGATACGCTTAATAAAAAaacatccggaggtaacgtaa t" /listShort="ygaF, perR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 893429..893448 /Source="Nicolas_upshift_promotors" /id="U670" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig=1 /xcortree=2268 /SigmaFactorBS="aacaagaacaatggcttcgggcttcagattcagctgagaTGG TTGTAatctggacaagaaTTGGATACGCTTAATAAAAAaacatccggaggtaacgtaa t" /listShort="ygaF, perR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 893429 /Source="Nicolas_upshifts" /id="U670" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig=1 /xcortree=2268 /SigmaFactorBS="aacaagaacaatggcttcgggcttcagattcagctgagaTGG TTGTAatctggacaagaaTTGGATACGCTTAATAAAAAaacatccggaggtaacgtaa t" /listShort="ygaF, perR" /GFF_Attribute="listLong" /label="upshifts" CDS 893468..893941 /gene="bcp" /locus_tag="BSU_08720" /old_locus_tag="BSU08720" /EC_number="1.11.1.15" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10644761, 11349039, 12950915, 21910476, 26723255; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peroxiredoxin with versatile activity" /protein_id="YP_054574.1" /db_xref="EnsemblGenomes-Gn:BSU08720" /db_xref="EnsemblGenomes-Tr:CAB12700" /db_xref="GOA:Q796Y8" /db_xref="InterPro:IPR000866" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR024706" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG12226" /db_xref="UniProtKB/Swiss-Prot:Q796Y8" /translation="MTIEIGQKAPDLELKGDHGETVKLSDYKGKYIVLYFYPKDMTPG CTTEACDFRDSHESFAELDAVIIGVSPDSQEKHGKFKEKHNLPFLLLVDDEHKLAEAF DVWKLKKNFGKEYMGIERSTFLIDKEGRLIKEWRKVKVKDHVAEALQTLKDMSEK*" /label="bcp CDS" gene 893468..893941 /gene="bcp" /locus_tag="BSU_08720" /old_locus_tag="BSU08720" /label="bcp gene" promotor_-35 893978..893985 /Source="Nicolas_upshift_promotors" /id="U671" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=1534 /SigmaFactorBS="ctatgagcctatgcttacttttaccctgatatCAATTGACaa attatcgtagaaAGAGTTACACTAATTATAAAcattacaatgtaagaattttttttag a" /listShort="perR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 894000..894019 /Source="Nicolas_upshift_promotors" /id="U671" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=1534 /SigmaFactorBS="ctatgagcctatgcttacttttaccctgatatCAATTGACaa attatcgtagaaAGAGTTACACTAATTATAAAcattacaatgtaagaattttttttag a" /listShort="perR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 894006 /Source="Nicolas_upshifts" /id="U671" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=1534 /SigmaFactorBS="ctatgagcctatgcttacttttaccctgatatCAATTGACaa attatcgtagaaAGAGTTACACTAATTATAAAcattacaatgtaagaattttttttag a" /listShort="perR" /GFF_Attribute="listLong" /label="upshifts" CDS 894064..894501 /gene="perR" /locus_tag="BSU_08730" /old_locus_tag="BSU08730" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1580225, 16541078, 16925555, 22194458, 27935957, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1580225, 16541078, 16925555, 22194458, 27935957, 22720735; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (Fur family)" /protein_id="NP_388753.1" /db_xref="EnsemblGenomes-Gn:BSU08730" /db_xref="EnsemblGenomes-Tr:CAB12701" /db_xref="GOA:P71086" /db_xref="InterPro:IPR002481" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2FE3" /db_xref="PDB:2RGV" /db_xref="PDB:3F8N" /db_xref="SubtiList:BG12227" /db_xref="UniProtKB/Swiss-Prot:P71086" /translation="MAAHELKEALETLKETGVRITPQRHAILEYLVNSMAHPTADDIY KALEGKFPNMSVATVYNNLRVFRESGLVKELTYGDASSRFDFVTSDHYHAICENCGKI VDFHYPGLDEVEQLAAHVTGFKVSHHRLEIYGVCQECSKKENH*" /label="perR CDS" gene 894064..894501 /gene="perR" /locus_tag="BSU_08730" /old_locus_tag="BSU08730" /label="perR gene" downshifts 894483 /Source="Nicolas_upshifts" /id="D437" /incds=0 /nref=149 /ntot=247 /MaxReadThrough="3.98479" /MaxDrop="7.52234" /score="1.62878623" /energy="-12.3" /TU="U670,U671" /idTUdmin="U670" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" CDS complement(894536..894889) /gene="ygzB" /locus_tag="BSU_08740" /old_locus_tag="BSU08740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="YP_054575.1" /db_xref="EnsemblGenomes-Gn:BSU08740" /db_xref="EnsemblGenomes-Tr:CAE01450" /db_xref="GOA:Q7WY74" /db_xref="InterPro:IPR020912" /db_xref="SubtiList:BG14192" /db_xref="UniProtKB/Swiss-Prot:Q7WY74" /translation="MAKYSSKINKIRTFALSLVFVGFIIMYIGIFFKESVLLSSLFMI LGLLSIGLSTVVYFWIGMLSTKAVRVICPGCDKETKVLGVVDMCMHCREPLTLDKGLE GKEFDESYNKKKMSK*" /label="ygzB CDS" gene complement(894536..894889) /gene="ygzB" /locus_tag="BSU_08740" /old_locus_tag="BSU08740" /label="ygzB gene" downshifts 894549 /Source="Nicolas_upshifts" /id="D438" /incds=0 /nref=1 /ntot=40 /MaxReadThrough="2.62283" /MaxDrop="4.13562" /score="-4.23596421" /energy="-12.5" /TU="NA" /idTUdmin="U670" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(894559) /Source="Nicolas_upshifts" /id="D439" /incds=0 /nref=182 /ntot=253 /MaxReadThrough="4.02571" /MaxDrop="6.23378" /score="9.51667757" /energy="-14.2" /TU="NA" /idTUdmin="U673" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 894885..894889 /Source="Nicolas_upshift_promotors" /id="U672" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.892107892107892" /psig="0.0739260739260739" /xcortree=2130 /SigmaFactorBS="ttaacgcaaatgttctgattttattaattttgctggagtatt tcGCCATgtccatcCCCCTCTGTTTTAACtatagcacaaacccgatgggattttcttc a" /listShort="S302, S303, ygxA" /listLong="S304, rrnD-16S" /label="promotor_-35" promotor_-10 894897..894911 /Source="Nicolas_upshift_promotors" /id="U672" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.892107892107892" /psig="0.0739260739260739" /xcortree=2130 /SigmaFactorBS="ttaacgcaaatgttctgattttattaattttgctggagtatt tcGCCATgtccatcCCCCTCTGTTTTAACtatagcacaaacccgatgggattttcttc a" /listShort="S302, S303, ygxA" /listLong="S304, rrnD-16S" /label="promotor_-10" misc_feature complement(894901..894920) /Source="Nicolas_upshift_promotors" /id="U673" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.949050949050949" /psig="0.998001998001998" /xcortree=432 /SigmaFactorBS="catatgtaaattccagttcaaccgaaaacatgaagaaaatcc catcgggttTGTGCTATAGTTAAAACAGAgggggatggacatggcgaaatactccagc a" /listShort="ygzB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 894901..894992 /Source="Nicolas_S_feature" /locus_tag="new_945324_945415" /HighExp="Cold, C30, H2O2, Etha, dia15, G135, Paraq, C90, G180, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.0739" /TUlongSig="NA" /TUlongPSig="NA" /label="S302" upshifts 894901 /Source="Nicolas_upshifts" /id="U672" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.892107892107892" /psig="0.0739260739260739" /xcortree=2130 /SigmaFactorBS="ttaacgcaaatgttctgattttattaattttgctggagtatt tcGCCATgtccatcCCCCTCTGTTTTAACtatagcacaaacccgatgggattttcttc a" /listShort="S302, S303, ygxA" /listLong="S304, rrnD-16S" /label="upshifts" upshifts complement(894911) /Source="Nicolas_upshifts" /id="U673" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.949050949050949" /psig="0.998001998001998" /xcortree=432 /SigmaFactorBS="catatgtaaattccagttcaaccgaaaacatgaagaaaatcc catcgggttTGTGCTATAGTTAAAACAGAgggggatggacatggcgaaatactccagc a" /listShort="ygzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 894969..894972 /Source="Nicolas_upshift_promotors" /id="U674" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.736263736263736" /psig="0.996003996003996" /xcortree=95 /SigmaFactorBS="tttcttcatgttttcggttgaactggaatttacatATGGaga gttactgtgaaATTGTTTATAATAGTTCAATgtgtttagaaaaaaggaatttcgtttt a" /listShort="S303, ygxA, S304" /listLong="rrnD-16S" /label="promotor_-35" promotor_-10 894987..895006 /Source="Nicolas_upshift_promotors" /id="U674" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.736263736263736" /psig="0.996003996003996" /xcortree=95 /SigmaFactorBS="tttcttcatgttttcggttgaactggaatttacatATGGaga gttactgtgaaATTGTTTATAATAGTTCAATgtgtttagaaaaaaggaatttcgtttt a" /listShort="S303, ygxA, S304" /listLong="rrnD-16S" /label="promotor_-10" S_feature 894994..895096 /Source="Nicolas_S_feature" /locus_tag="new_945417_945519" /HighExp="BMM, Cold, LBGstat, C30, Oxctl, LBGexp, Paraq, G180, Lbexp, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="0.996, 0.0739" /TUlongSig="NA" /TUlongPSig="NA" /label="S303" upshifts 894994 /Source="Nicolas_upshifts" /id="U674" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.736263736263736" /psig="0.996003996003996" /xcortree=95 /SigmaFactorBS="tttcttcatgttttcggttgaactggaatttacatATGGaga gttactgtgaaATTGTTTATAATAGTTCAATgtgtttagaaaaaaggaatttcgtttt a" /listShort="S303, ygxA, S304" /listLong="rrnD-16S" /label="upshifts" CDS 895097..895981 /gene="ygxA" /locus_tag="BSU_08750" /old_locus_tag="BSU08750" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388755.1" /db_xref="EnsemblGenomes-Gn:BSU08750" /db_xref="EnsemblGenomes-Tr:CAB12703" /db_xref="InterPro:IPR029348" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10951" /db_xref="UniProtKB/Swiss-Prot:Q04385" /translation="MENLLRPIYQERASHPNTLAVIMIERRNKTSSLTDNFDAALLVI VKDADEPVFIKHYEFDHQTASLHVVTDSQIQEWILLGTNRRIIDWIVNGRVLFDRNEY VVELIDRLNTFPFAERKLKIGLEYGKLIRRYVEGKAFFEANQFLDAYNAVVHALHHLA RIEVIDRGFHPETTVWSQVRQMEPQVYKLYSELIESHESLEKRLELLFLANDFLIHSK AEIGSAHLFEVMKEKDIWQFGELLQHHDLKHFTQDLGVMLDYLTEKGLINVCQIETKG QAVYHRGYSFKKGVDSDS*" /label="ygxA CDS" gene 895097..895981 /gene="ygxA" /locus_tag="BSU_08750" /old_locus_tag="BSU08750" /label="ygxA gene" promotor_-35 895964..895971 /Source="Nicolas_upshift_promotors" /id="U675" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2619 /SigmaFactorBS="cgaggatattcttttaaaaaaggtGTTGACTCtgattcttga ccgTGTTATATTATTAAACGTCGctgatgcgcttctgagaaaacaagctcacagcggc g" /listShort="S304, rrnD-16S" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 895985..896004 /Source="Nicolas_upshift_promotors" /id="U675" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2619 /SigmaFactorBS="cgaggatattcttttaaaaaaggtGTTGACTCtgattcttga ccgTGTTATATTATTAAACGTCGctgatgcgcttctgagaaaacaagctcacagcggc g" /listShort="S304, rrnD-16S" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 896000..896272 /Source="Nicolas_S_feature" /locus_tag="new_946423_946695" /HighExp="LBGstat, Oxctl, C30, Paraq, GM 120, H2O2, HPh, G150, LPh, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.106881" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.996" /TUlongSig="Sig-" /TUlongPSig="0.0739" /label="S304" upshifts 896000 /Source="Nicolas_upshifts" /id="U675" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2619 /SigmaFactorBS="cgaggatattcttttaaaaaaggtGTTGACTCtgattcttga ccgTGTTATATTATTAAACGTCGctgatgcgcttctgagaaaacaagctcacagcggc g" /listShort="S304, rrnD-16S" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(896033) /Source="Nicolas_upshifts" /id="D440" /incds=0 /nref=1 /ntot=20 /MaxReadThrough="2.70619" /MaxDrop="3.85046" /score="4.43428373" /energy="-7.8" /TU="NA" /idTUdmin="U673" /TUdmin="-1474" /isTUend="FALSE" /label="downshifts" rRNA 896273..897827 /gene="rrnD-16S" /locus_tag="BSU_rRNA_22" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnD-16S rRNA" gene 896273..897827 /gene="rrnD-16S" /locus_tag="BSU_rRNA_22" /label="rrnD-16S gene" rRNA 897995..900922 /gene="rrnD-23S" /locus_tag="BSU_rRNA_17" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnD-23S rRNA" gene 897995..900922 /gene="rrnD-23S" /locus_tag="BSU_rRNA_17" /label="rrnD-23S gene" S_feature 900923..901008 /Source="Nicolas_S_feature" /locus_tag="new_951346_951431" /HighExp="G135, C30, Oxctl, Paraq, LBGstat, dia0, HiTm, Fru, G180, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S305" promotor_-35 900984..900991 /Source="Nicolas_upshift_promotors" /id="U676" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.852147852147852" /psig=1 /xcortree=2417 /SigmaFactorBS="ctagttttgagagaataagtttttcaaaaaaacaCTTGATTT tctcaagaatacaTAGTATAATGTTAAATGTCActgaaattgtctggtgatgatggcg a" /listShort="rrnD-5S, trnD-Asn, trnD-Ser, trnD-Glu, trnD-Val, trnD-Met, trnD-Asp, trnD-Phe, trnD-Thr, trnD-Tyr, trnD-Trp, trnD-His, trnD-Gln, trnD-Gly, trnD-Cys, trnD-Leu1, S306, S307, trnD-Leu2, ygzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 901005..901024 /Source="Nicolas_upshift_promotors" /id="U676" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.852147852147852" /psig=1 /xcortree=2417 /SigmaFactorBS="ctagttttgagagaataagtttttcaaaaaaacaCTTGATTT tctcaagaatacaTAGTATAATGTTAAATGTCActgaaattgtctggtgatgatggcg a" /listShort="rrnD-5S, trnD-Asn, trnD-Ser, trnD-Glu, trnD-Val, trnD-Met, trnD-Asp, trnD-Phe, trnD-Thr, trnD-Tyr, trnD-Trp, trnD-His, trnD-Gln, trnD-Gly, trnD-Cys, trnD-Leu1, S306, S307, trnD-Leu2, ygzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 901010 /Source="Nicolas_upshifts" /id="U676" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.852147852147852" /psig=1 /xcortree=2417 /SigmaFactorBS="ctagttttgagagaataagtttttcaaaaaaacaCTTGATTT tctcaagaatacaTAGTATAATGTTAAATGTCActgaaattgtctggtgatgatggcg a" /listShort="rrnD-5S, trnD-Asn, trnD-Ser, trnD-Glu, trnD-Val, trnD-Met, trnD-Asp, trnD-Phe, trnD-Thr, trnD-Tyr, trnD-Trp, trnD-His, trnD-Gln, trnD-Gly, trnD-Cys, trnD-Leu1, S306, S307, trnD-Leu2, ygzA" /GFF_Attribute="listLong" /label="upshifts" rRNA 901034..901149 /gene="rrnD-5S" /locus_tag="BSU_rRNA_18" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnD-5S rRNA" gene 901034..901149 /gene="rrnD-5S" /locus_tag="BSU_rRNA_18" /label="rrnD-5S gene" tRNA 901159..901233 /gene="asnTA" /locus_tag="BSU_tRNA_29" /product="tRNA-Asn" /inference="profile:tRNAscan:1.23" /note="asparagine transfer RNA (GUU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="asnTA tRNA" gene 901159..901233 /gene="asnTA" /locus_tag="BSU_tRNA_29" /label="asnTA gene" tRNA 901239..901330 /gene="trnD-Ser" /locus_tag="BSU_tRNA_30" /product="tRNA-Ser" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ser(GGA); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Ser tRNA" gene 901239..901330 /gene="trnD-Ser" /locus_tag="BSU_tRNA_30" /label="trnD-Ser gene" downshifts 901326 /Source="Nicolas_upshifts" /id="D441" /incds=0 /nref=2 /ntot=20 /MaxReadThrough="7.64297" /MaxDrop="4.37505" /score="-9.7424199" /energy="-11" /TU="U676" /idTUdmin="U677" /TUdmin="-1562" /isTUend="FALSE" /label="downshifts" tRNA 901365..901436 /gene="trnD-Glu" /locus_tag="BSU_tRNA_31" /product="tRNA-Glu" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Glu(UUC); Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Glu tRNA" gene 901365..901436 /gene="trnD-Glu" /locus_tag="BSU_tRNA_31" /label="trnD-Glu gene" tRNA 901446..901521 /gene="trnD-Val" /locus_tag="BSU_tRNA_32" /product="tRNA-Val" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Val(UAC); Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Val tRNA" gene 901446..901521 /gene="trnD-Val" /locus_tag="BSU_tRNA_32" /label="trnD-Val gene" tRNA 901531..901607 /gene="trnD-Met" /locus_tag="BSU_tRNA_33" /product="tRNA-Met" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Met(CAU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Met tRNA" gene 901531..901607 /gene="trnD-Met" /locus_tag="BSU_tRNA_33" /label="trnD-Met gene" tRNA 901619..901695 /gene="trnD-Asp" /locus_tag="BSU_tRNA_34" /product="tRNA-Asp" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Asp(GUC); Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Asp tRNA" gene 901619..901695 /gene="trnD-Asp" /locus_tag="BSU_tRNA_34" /label="trnD-Asp gene" tRNA 901708..901783 /gene="trnD-Phe" /locus_tag="BSU_tRNA_35" /product="tRNA-Phe" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Phe(GAA); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Phe tRNA" gene 901708..901783 /gene="trnD-Phe" /locus_tag="BSU_tRNA_35" /label="trnD-Phe gene" tRNA 901789..901861 /gene="trnD-Thr" /locus_tag="BSU_tRNA_36" /product="tRNA-Thr" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Thr(UGU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Thr tRNA" gene 901789..901861 /gene="trnD-Thr" /locus_tag="BSU_tRNA_36" /label="trnD-Thr gene" tRNA 901884..901968 /gene="trnD-Tyr" /locus_tag="BSU_tRNA_37" /product="tRNA-Tyr" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Tyr(GUA); Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Tyr tRNA" gene 901884..901968 /gene="trnD-Tyr" /locus_tag="BSU_tRNA_37" /label="trnD-Tyr gene" tRNA 901974..902047 /gene="trnD-Trp" /locus_tag="BSU_tRNA_38" /product="tRNA-Trp" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Trp(CCA); Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Trp tRNA" gene 901974..902047 /gene="trnD-Trp" /locus_tag="BSU_tRNA_38" /label="trnD-Trp gene" tRNA 902072..902147 /gene="trnD-His" /locus_tag="BSU_tRNA_39" /product="tRNA-His" /inference="profile:tRNAscan:1.23" /note="transfer RNA-His(GUG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-His tRNA" gene 902072..902147 /gene="trnD-His" /locus_tag="BSU_tRNA_39" /label="trnD-His gene" tRNA 902157..902228 /gene="trnD-Gln" /locus_tag="BSU_tRNA_40" /product="tRNA-Gln" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gln(UUG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Gln tRNA" gene 902157..902228 /gene="trnD-Gln" /locus_tag="BSU_tRNA_40" /label="trnD-Gln gene" tRNA 902278..902352 /gene="glyTB" /locus_tag="BSU_tRNA_41" /product="tRNA-Gly" /inference="profile:tRNAscan:1.23" /note="glycine transfer RNA (GCC); Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="glyTB tRNA" gene 902278..902352 /gene="glyTB" /locus_tag="BSU_tRNA_41" /label="glyTB gene" tRNA 902358..902428 /gene="cysTA" /locus_tag="BSU_tRNA_42" /product="tRNA-Cys" /inference="profile:tRNAscan:1.23" /note="cysteine tRNA (GCA); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="cysTA tRNA" gene 902358..902428 /gene="cysTA" /locus_tag="BSU_tRNA_42" /label="cysTA gene" tRNA 902436..902524 /gene="leuTA" /locus_tag="BSU_tRNA_43" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="leucine RNA (UAA); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="leuTA tRNA" gene 902436..902524 /gene="leuTA" /locus_tag="BSU_tRNA_43" /label="leuTA gene" S_feature 902525..902601 /Source="Nicolas_S_feature" /locus_tag="new_952948_953024" /HighExp="Paraq, C30, Oxctl, G180, G135, Heat, BMM, LBGexp, dia15, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S306" downshifts 902558 /Source="Nicolas_upshifts" /id="D442" /incds=0 /nref=18 /ntot=231 /MaxReadThrough="5.36857" /MaxDrop="5.05259" /score="16.6649124" /energy="-8.9" /TU="U676" /idTUdmin="U677" /TUdmin="-330" /isTUend="FALSE" /label="downshifts" S_feature 902603..902771 /Source="Nicolas_S_feature" /locus_tag="new_953026_953194" /HighExp="Heat, Paraq, BMM, Oxctl, H2O2, Cold, G180, Pyr, C30, Glu" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S307" promotor_-35 902728..902735 /Source="Nicolas_upshift_promotors" /id="U677" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.927072927072927" /psig="0.998001998001998" /xcortree=687 /SigmaFactorBS="acttttttgaaatacGTTGACACtttatgagatccaTGATAT ATTTATATTCGTCGgttagatacgacgtaaaacttgccggtgtggcggaattggcaga c" /listShort="trnD-Leu2" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 902734 /Source="Nicolas_upshifts" /id="D443" /incds=0 /nref=1 /ntot=14 /MaxReadThrough="3.84674" /MaxDrop="3.439" /score="35.1424037" /energy="-12.4" /TU="U676" /idTUdmin="U677" /TUdmin="-154" /isTUend="FALSE" /label="downshifts" promotor_-10 902749..902768 /Source="Nicolas_upshift_promotors" /id="U677" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.927072927072927" /psig="0.998001998001998" /xcortree=687 /SigmaFactorBS="acttttttgaaatacGTTGACACtttatgagatccaTGATAT ATTTATATTCGTCGgttagatacgacgtaaaacttgccggtgtggcggaattggcaga c" /listShort="trnD-Leu2" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 902773 /Source="Nicolas_upshifts" /id="U677" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.927072927072927" /psig="0.998001998001998" /xcortree=687 /SigmaFactorBS="acttttttgaaatacGTTGACACtttatgagatccaTGATAT ATTTATATTCGTCGgttagatacgacgtaaaacttgccggtgtggcggaattggcaga c" /listShort="trnD-Leu2" /GFF_Attribute="listLong" /label="upshifts" tRNA 902790..902871 /gene="leuTB" /locus_tag="BSU_tRNA_44" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="leucine tRNA(CAA); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="leuTB tRNA" gene 902790..902871 /gene="leuTB" /locus_tag="BSU_tRNA_44" /label="leuTB gene" promotor_-10 complement(902807..902824) /Source="Nicolas_upshift_promotors" /id="U678" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.925074925074925" /psig="0.012987012987013" /xcortree=395 /SigmaFactorBS="accggtggtcggggtcgaacCGACACtccagaaggaacacga ttttGAGTCGTGCGCGTCTGCCaattccgccacaccggcaagttttacgtcgtatcta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(902810) /Source="Nicolas_upshifts" /id="U678" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.925074925074925" /psig="0.012987012987013" /xcortree=395 /SigmaFactorBS="accggtggtcggggtcgaacCGACACtccagaaggaacacga ttttGAGTCGTGCGCGTCTGCCaattccgccacaccggcaagttttacgtcgtatcta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(902845..902850) /Source="Nicolas_upshift_promotors" /id="U678" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.925074925074925" /psig="0.012987012987013" /xcortree=395 /SigmaFactorBS="accggtggtcggggtcgaacCGACACtccagaaggaacacga ttttGAGTCGTGCGCGTCTGCCaattccgccacaccggcaagttttacgtcgtatcta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(902880) /Source="Nicolas_upshifts" /id="D444" /incds=0 /nref=5 /ntot=151 /MaxReadThrough="1.64364" /MaxDrop="6.28675" /score="7.71223568" /energy="-12.4" /TU="NA" /idTUdmin="U679" /TUdmin=18 /isTUend="TRUE" /label="downshifts" CDS complement(902950..903726) /gene="spo0M" /locus_tag="BSU_08760" /old_locus_tag="BSU08760" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9795118, 22142536, 26625291, 28234965" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9795118, 22142536, 26625291, 28234965; Product type r: regulator" /codon_start=1 /transl_table=11 /product="protein involved in the control of the cell cycle as a function of the environment" /protein_id="NP_388756.2" /db_xref="EnsemblGenomes-Gn:BSU08760" /db_xref="EnsemblGenomes-Tr:CAB12704" /db_xref="GOA:P71088" /db_xref="InterPro:IPR009776" /db_xref="InterPro:IPR014756" /db_xref="PDB:5CL2" /db_xref="SubtiList:BG12229" /db_xref="UniProtKB/Swiss-Prot:P71088" /translation="MSFFKKLAASAGIGAAKVDTILEKDAYFPGEEVQGTVHVKGGKI AQDIRYIDLQLSTRYVIVKDDEEHRKYATIHSFRVTGSFTIQPGEEHQFPFTFTLPLD TPITVGKVEVAVVTDLDIQGGIDKSDHDRIFVEAHPWIENVLEAIENLGFRLNEADCE QAPYFQRRLPFVQEFEFVPTSGYYRQMLDELELIFLLDEDGLEIIFEVDRRARGLRGW LEEMYNDGEQLVRVRFSQSELEDTEELEEVLEEILDQYAE*" /label="spo0M CDS" gene complement(902950..903726) /gene="spo0M" /locus_tag="BSU_08760" /old_locus_tag="BSU08760" /label="spo0M gene" downshifts complement(902964) /Source="Nicolas_upshifts" /id="D445" /incds=0 /nref=9 /ntot=131 /MaxReadThrough="6.06864" /MaxDrop="6.58787" /score="6.75662782" /energy="-7" /TU="U679" /idTUdmin="U679" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(903753..903768) /Source="Nicolas_upshift_promotors" /id="U679" /multdbtbs="SigH" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1665 /SigmaFactorBS="tgtccctaggccgagacgaataataggaaaaaagtatgaatc aaaCGAATCTTTTttcctccttcttACGTATATCTGTTGAGaaaaaagaaaaagggga a" /listShort="spo0M" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(903775) /Source="Nicolas_upshifts" /id="U679" /multdbtbs="SigH" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1665 /SigmaFactorBS="tgtccctaggccgagacgaataataggaaaaaagtatgaatc aaaCGAATCTTTTttcctccttcttACGTATATCTGTTGAGaaaaaagaaaaagggga a" /listShort="spo0M" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(903781..903790) /Source="Nicolas_upshift_promotors" /id="U679" /multdbtbs="SigH" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1665 /SigmaFactorBS="tgtccctaggccgagacgaataataggaaaaaagtatgaatc aaaCGAATCTTTTttcctccttcttACGTATATCTGTTGAGaaaaaagaaaaagggga a" /listShort="spo0M" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 903810..903816 /Source="Nicolas_upshift_promotors" /id="U680" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=873 /SigmaFactorBS="ggaggaaaaaagattcgtttgattcatacttttttcCTATTA TtcgtctcggcctagGGACAGACTAAGaataatattgaaaataaaggagtcgatggaa g" /listShort="ygzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 903831..903842 /Source="Nicolas_upshift_promotors" /id="U680" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=873 /SigmaFactorBS="ggaggaaaaaagattcgtttgattcatacttttttcCTATTA TtcgtctcggcctagGGACAGACTAAGaataatattgaaaataaaggagtcgatggaa g" /listShort="ygzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 903834 /Source="Nicolas_upshifts" /id="U680" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=873 /SigmaFactorBS="ggaggaaaaaagattcgtttgattcatacttttttcCTATTA TtcgtctcggcctagGGACAGACTAAGaataatattgaaaataaaggagtcgatggaa g" /listShort="ygzA" /GFF_Attribute="listLong" /label="upshifts" CDS 903868..904071 /gene="ygzA" /locus_tag="BSU_08770" /old_locus_tag="BSU08770" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388757.2" /db_xref="EnsemblGenomes-Gn:BSU08770" /db_xref="EnsemblGenomes-Tr:CAB12705" /db_xref="SubtiList:BG12981" /db_xref="UniProtKB/Swiss-Prot:O31586" /translation="MEVNKESLVADELHRMFLAGELQITVEEDINNISERLRNGDLSL DRLSGEDVFIKETVNEALRRVEQ*" /label="ygzA CDS" gene 903868..904071 /gene="ygzA" /locus_tag="BSU_08770" /old_locus_tag="BSU08770" /label="ygzA gene" downshifts 904054 /Source="Nicolas_upshifts" /id="D446" /incds=0 /nref=22 /ntot=97 /MaxReadThrough="1.47004" /MaxDrop="5.47861" /score="15.4081475" /energy="-18.2" /TU="NA" /idTUdmin="U676" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(904130) /Source="Nicolas_upshifts" /id="D447" /incds=0 /nref=10 /ntot=35 /MaxReadThrough="1.31339" /MaxDrop="4.8918" /score="26.0684119" /energy="-18.2" /TU="NA" /idTUdmin="U681" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(904156..904428) /gene="ygzC" /locus_tag="BSU_08779" /old_locus_tag="BSU08779" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="YP_003097696.1" /db_xref="EnsemblGenomes-Gn:BSU08779" /db_xref="EnsemblGenomes-Tr:CAX52583" /db_xref="GOA:C0H3X8" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR012851" /db_xref="UniProtKB/Swiss-Prot:C0H3X8" /translation="MYRSKKQSQILSYQELLKKQRRWFPIEQSLCPKDILDLLTTIKT SINKYTVATTATENPHIRRALHDQLDTAVYLHDELSDLLLEKGWLG*" /label="ygzC CDS" gene complement(904156..904428) /gene="ygzC" /locus_tag="BSU_08779" /old_locus_tag="BSU08779" /label="ygzC gene" promotor_-10 complement(904387..904405) /Source="Nicolas_upshift_promotors" /id="U681" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.94005994005994" /psig="0.94005994005994" /xcortree=1185 /SigmaFactorBS="caaaatttgttgcttattatagcatttTGTATAgaagcaaga aacaaagTCAAATACTTTCTTATCAGgagctgctaaaaaaacaaaggaggtggtttcc c" /listShort="ygzC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(904394) /Source="Nicolas_upshifts" /id="U681" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.94005994005994" /psig="0.94005994005994" /xcortree=1185 /SigmaFactorBS="caaaatttgttgcttattatagcatttTGTATAgaagcaaga aacaaagTCAAATACTTTCTTATCAGgagctgctaaaaaaacaaaggaggtggtttcc c" /listShort="ygzC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 904409..904416 /Source="Nicolas_upshift_promotors" /id="U682" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.478521478521479" /psig=1 /xcortree=2885 /SigmaFactorBS="ttagcagctcctgataagaaagtatttgacttTGTTTCTTgc ttctatacaaAATGCTATAATAAGCAACAAattttgttggggggtgtgatgatgaagc a" /listShort="ygaJ" /listLong="NA, thiC, S308" /label="promotor_-35" promotor_-35 complement(904422..904427) /Source="Nicolas_upshift_promotors" /id="U681" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.94005994005994" /psig="0.94005994005994" /xcortree=1185 /SigmaFactorBS="caaaatttgttgcttattatagcatttTGTATAgaagcaaga aacaaagTCAAATACTTTCTTATCAGgagctgctaaaaaaacaaaggaggtggtttcc c" /listShort="ygzC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 904429..904448 /Source="Nicolas_upshift_promotors" /id="U682" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.478521478521479" /psig=1 /xcortree=2885 /SigmaFactorBS="ttagcagctcctgataagaaagtatttgacttTGTTTCTTgc ttctatacaaAATGCTATAATAAGCAACAAattttgttggggggtgtgatgatgaagc a" /listShort="ygaJ" /listLong="NA, thiC, S308" /label="promotor_-10" upshifts 904437 /Source="Nicolas_upshifts" /id="U682" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.478521478521479" /psig=1 /xcortree=2885 /SigmaFactorBS="ttagcagctcctgataagaaagtatttgacttTGTTTCTTgc ttctatacaaAATGCTATAATAAGCAACAAattttgttggggggtgtgatgatgaagc a" /listShort="ygaJ" /listLong="NA, thiC, S308" /label="upshifts" CDS 904470..905162 /gene="ygaJ" /locus_tag="BSU_08780" /old_locus_tag="BSU08780" /EC_number="3.4.21.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative peptidase" /protein_id="NP_388758.2" /db_xref="EnsemblGenomes-Gn:BSU08780" /db_xref="EnsemblGenomes-Tr:CAB12706" /db_xref="GOA:P71089" /db_xref="InterPro:IPR005320" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG12230" /db_xref="UniProtKB/Swiss-Prot:P71089" /translation="MKQIIAMGGGGFSMEPDNLSLDQYILNQSKREQPRICFLPTASG DSQNYIQRFYHAFQTLDCVPSHLSLFKPPSSDLVSFVMEMDVIYVGGGNTRNLLVLWK EWGLDHILREAWKNGVVVAGISAGAICWFEEGVTDSAGPLTSLKSLGFLQGSFCPHYD GEKDRRPAYHQLISNKFLCSGYAADDGAALHFINDQLFQTVSSRSGAKAYRVMMAEHE IAEIPLPVKYLG*" /label="ygaJ CDS" gene 904470..905162 /gene="ygaJ" /locus_tag="BSU_08780" /old_locus_tag="BSU08780" /label="ygaJ gene" promotor_-35 905191..905195 /Source="Nicolas_upshift_promotors" /id="U684" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.616383616383616" /psig="0.946053946053946" /xcortree=2883 /SigmaFactorBS="tctatattcctcTTTTTttcagattgatttTATGATAAGATG AGTGCGAAatcaatagttactgggggtgcccgctttcgggctgagagagaaggcaagc t" /listShort="NA, thiC, S308" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(905194..905213) /Source="Nicolas_upshift_promotors" /id="U683" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.863136863136863" /psig="0.997002997002997" /xcortree=2976 /SigmaFactorBS="tctcagcccgaaagcgggcacccccagtaacTATTGATTtcg cactcatcttaTCATAAAATCAATCTGAAAAaaagaggaatatagataatattcagcc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(905206) /Source="Nicolas_upshifts" /id="U683" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.863136863136863" /psig="0.997002997002997" /xcortree=2976 /SigmaFactorBS="tctcagcccgaaagcgggcacccccagtaacTATTGATTtcg cactcatcttaTCATAAAATCAATCTGAAAAaaagaggaatatagataatattcagcc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 905209..905228 /Source="Nicolas_upshift_promotors" /id="U684" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.616383616383616" /psig="0.946053946053946" /xcortree=2883 /SigmaFactorBS="tctatattcctcTTTTTttcagattgatttTATGATAAGATG AGTGCGAAatcaatagttactgggggtgcccgctttcgggctgagagagaaggcaagc t" /listShort="NA, thiC, S308" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(905228..905235) /Source="Nicolas_upshift_promotors" /id="U683" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.863136863136863" /psig="0.997002997002997" /xcortree=2976 /SigmaFactorBS="tctcagcccgaaagcgggcacccccagtaacTATTGATTtcg cactcatcttaTCATAAAATCAATCTGAAAAaaagaggaatatagataatattcagcc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" misc_RNA 905232..905339 /gene="tswD" /locus_tag="BSU_misc_RNA_11" /product="thiamine pyrophosphate riboswitch" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11470904, 12410317, 15862294, 16728979, 16962976, 17307816, 18179415, 18776013; Product type n: RNA" /function="16.3: Control" /label="tswD RNA" gene 905232..905339 /gene="tswD" /locus_tag="BSU_misc_RNA_11" /label="tswD gene" upshifts 905239 /Source="Nicolas_upshifts" /id="U684" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.616383616383616" /psig="0.946053946053946" /xcortree=2883 /SigmaFactorBS="tctatattcctcTTTTTttcagattgatttTATGATAAGATG AGTGCGAAatcaatagttactgggggtgcccgctttcgggctgagagagaaggcaagc t" /listShort="NA, thiC, S308" /GFF_Attribute="listLong" /label="upshifts" downshifts 905370 /Source="Nicolas_upshifts" /id="D448" /incds=0 /nref=13 /ntot=48 /MaxReadThrough="8.09735" /MaxDrop="5.74046" /score="17.5556194" /energy="-12.4" /TU="U684" /idTUdmin="U682" /TUdmin=152 /isTUend="FALSE" /label="downshifts" CDS 905472..907244 /gene="thiC" /locus_tag="BSU_08790" /old_locus_tag="BSU08790" /EC_number="4.1.99.17" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8432721, 9370266, 10382260, 16291685, 26443755" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8432721, 9370266, 10382260, 16291685, 26443755; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphomethylpyrimidine synthase" /protein_id="NP_388759.2" /db_xref="EnsemblGenomes-Gn:BSU08790" /db_xref="EnsemblGenomes-Tr:CAB12707" /db_xref="GOA:P45740" /db_xref="InterPro:IPR002817" /db_xref="InterPro:IPR025747" /db_xref="SubtiList:BG11246" /db_xref="UniProtKB/Swiss-Prot:P45740" /translation="MQNNSVQQANISIMSSFSGSKKVYVEGSSSDIQVPMREIALSPT TGSFGEEENAPVRVYDTSGPYTDPEVTINIQEGLKPLRQKWITERGDVEEYEGRAIKP EDNGYKKAKPNVSYPGLKRKPLRAKAGQNVTQMHYAKKGIITPEMEFIAIREHVSPEF VRDEVASGRAIIPSNINHPESEPMIIGRNFHVKINANIGNSAVTSSIEEEVEKMTWAI RWGADTMMDLSTGKDIHTTREWIIRNCPVPVGTVPIYQALEKVNGVAEDLTWEIYRDT LIEQAEQGVDYFTIHAGVLLRYVPLTAKRTTGIVSRGGAIMAQWCLAHHQESFLYTHF EEICEIMKMYDIAFSLGDGLRPGSIADANDEAQFAELETLGELTQIAWKHDVQVMIEG PGHVPMHKIKENVDKQMDICKEAPFYTLGPLTTDIAPGYDHITSAIGAAMIGWYGTAM LCYVTPKEHLGLPNRDDVREGVITYKIAAHAADLAKGHPGAQIRDDALSKARFEFRWR DQFNLSLDPERALEYHDETLPAEGAKTAHFCSMCGPKFCSMRISQDIRDYAKKNDLSE AEAINKGLKEKAKEFVDTGSNLYQ*" /label="thiC CDS" gene 905472..907244 /gene="thiC" /locus_tag="BSU_08790" /old_locus_tag="BSU08790" /label="thiC gene" downshifts 907220 /Source="Nicolas_upshifts" /id="D449" /incds=0 /nref=166 /ntot=257 /MaxReadThrough="5.77069" /MaxDrop="5.3684" /score="25.2366359" /energy="-15.3" /TU="U684" /idTUdmin="U684" /TUdmin="-946" /isTUend="FALSE" /label="downshifts" S_feature 907265..908190 /Source="Nicolas_S_feature" /locus_tag="new_957688_958613" /HighExp="HiOs, GM-0.1, GM 45, GM 60, GM-0.2, BMM, MG 90, T-5.40H, MG 15, MG 25" /AntisenseName="ygaK" /AntisenseCor="-9.7288827054566707E-2" /AntisenseRegPval="-1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.946" /TUlongSig="SigA" /TUlongPSig=1 /label="S308" CDS complement(907282..908637) /gene="ygaK" /locus_tag="BSU_08800" /old_locus_tag="BSU08800" /EC_number="1.21.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8972604; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative FAD-dependent oxido-reductase" /protein_id="NP_388760.2" /db_xref="EnsemblGenomes-Gn:BSU08800" /db_xref="EnsemblGenomes-Tr:CAB12708" /db_xref="GOA:Q796Y5" /db_xref="InterPro:IPR006094" /db_xref="InterPro:IPR012951" /db_xref="InterPro:IPR016166" /db_xref="InterPro:IPR016167" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG12231" /db_xref="UniProtKB/Swiss-Prot:Q796Y5" /translation="MEKTKLTGRIVTRDDPDYNEARTNINLSLERYPDIIVFCQNKQD ALNALKWARENRVPFRIRGGRHSYENFSLLNNGLVIDLSEMKKITVNQDKKLAYIEAG AELGEVYRTLWQYGLTLPAGTIANVGLTGLTLGGGIGLLTRAAGLTCDSLVQLEMIVA DEKEGADLITVSCSNHPDLFWASQGGGGGNFGIVTSMTFKAVPISQVSIFSITWGWDD FEEVYNTWQNWAPYTDDRLTSSIEFWPKEVNRIEALGQFVGPKTELKKLLKPLLKAGS PTSGMVKTTPFIEAVTFFNSPGGNQPQKMKRSGSFIEKPLSERAISTIKHFLEHAPNQ NASVWQQALGGAAGRVAPDQTAFYYRDAIIAQEYLTNWTSPGEKRQNVRWIEGLRTSL SKETMGDYVNWPDIEIRNWPRTYYGENVERLRRVKTTYDPENVFRFEQSIPPLRRSLF F*" /label="ygaK CDS" gene complement(907282..908637) /gene="ygaK" /locus_tag="BSU_08800" /old_locus_tag="BSU08800" /label="ygaK gene" promotor_-10 complement(908665..908684) /Source="Nicolas_upshift_promotors" /id="U685" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1414 /SigmaFactorBS="tgttgacactgtatcagattgcatccccgctttttCCTTATA CACtcttttcccctgaCGCATAAGCTAGAGAAACTAgaatacgagagaaagagatgtg g" /listShort="ygaK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(908682) /Source="Nicolas_upshifts" /id="U685" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1414 /SigmaFactorBS="tgttgacactgtatcagattgcatccccgctttttCCTTATA CACtcttttcccctgaCGCATAAGCTAGAGAAACTAgaatacgagagaaagagatgtg g" /listShort="ygaK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(908698..908707) /Source="Nicolas_upshift_promotors" /id="U685" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1414 /SigmaFactorBS="tgttgacactgtatcagattgcatccccgctttttCCTTATA CACtcttttcccctgaCGCATAAGCTAGAGAAACTAgaatacgagagaaagagatgtg g" /listShort="ygaK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 908755..908761 /Source="Nicolas_upshift_promotors" /id="U686" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.48951048951049" /psig="0.954045954045954" /xcortree=1737 /SigmaFactorBS="cctcaaaaaatAGTTGACaggtcggtattgtaTGAATTAACA TGGTCAGTACaaatttttcaaatttatcgcgctgatcggaacaccgaaggctcttatc g" /listShort="senS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 908776..908795 /Source="Nicolas_upshift_promotors" /id="U686" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.48951048951049" /psig="0.954045954045954" /xcortree=1737 /SigmaFactorBS="cctcaaaaaatAGTTGACaggtcggtattgtaTGAATTAACA TGGTCAGTACaaatttttcaaatttatcgcgctgatcggaacaccgaaggctcttatc g" /listShort="senS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 908804 /Source="Nicolas_upshifts" /id="U686" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.48951048951049" /psig="0.954045954045954" /xcortree=1737 /SigmaFactorBS="cctcaaaaaatAGTTGACaggtcggtattgtaTGAATTAACA TGGTCAGTACaaatttttcaaatttatcgcgctgatcggaacaccgaaggctcttatc g" /listShort="senS" /GFF_Attribute="listLong" /label="upshifts" CDS 908888..909085 /gene="senS" /locus_tag="BSU_08810" /old_locus_tag="BSU08810" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1479343, 2108127, 8323536, 16321961" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1479343, 2108127, 8323536, 16321961; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (repressor of ScoC)" /protein_id="NP_388761.2" /db_xref="EnsemblGenomes-Gn:BSU08810" /db_xref="EnsemblGenomes-Tr:CAB12709" /db_xref="GOA:P21344" /db_xref="InterPro:IPR025004" /db_xref="SubtiList:BG10747" /db_xref="UniProtKB/Swiss-Prot:P21344" /translation="MGVKKEKGRKRFRKRKTYGNQILPLELLIEKNKREIINSAELME EIYMKIDEKHTQCVTKYKKTR*" /label="senS CDS" gene 908888..909085 /gene="senS" /locus_tag="BSU_08810" /old_locus_tag="BSU08810" /label="senS gene" CDS complement(909112..910563) /gene="katA" /locus_tag="BSU_08820" /old_locus_tag="BSU08820" /EC_number="1.11.1.6" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12029044, 12486061, 16535198, 22194458, 27935957" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12029044, 12486061, 16535198, 22194458, 27935957; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="vegetative catalase 1" /protein_id="NP_388762.2" /db_xref="EnsemblGenomes-Gn:BSU08820" /db_xref="EnsemblGenomes-Tr:CAB12710" /db_xref="GOA:P26901" /db_xref="InterPro:IPR002226" /db_xref="InterPro:IPR010582" /db_xref="InterPro:IPR011614" /db_xref="InterPro:IPR018028" /db_xref="InterPro:IPR020835" /db_xref="InterPro:IPR024708" /db_xref="InterPro:IPR024711" /db_xref="InterPro:IPR037060" /db_xref="SubtiList:BG10849" /db_xref="UniProtKB/Swiss-Prot:P26901" /translation="MSSNKLTTSWGAPVGDNQNSMTAGSRGPTLIQDVHLLEKLAHFN RERVPERVVHAKGAGAHGYFEVTNDVTKYTKAAFLSEVGKRTPLFIRFSTVAGELGSA DTVRDPRGFAVKFYTEEGNYDIVGNNTPVFFIRDAIKFPDFIHTQKRDPKTHLKNPTA VWDFWSLSPESLHQVTILMSDRGIPATLRHMHGFGSHTFKWTNAEGEGVWIKYHFKTE QGVKNLDVNTAAKIAGENPDYHTEDLFNAIENGDYPAWKLYVQIMPLEDANTYRFDPF DVTKVWSQKDYPLIEVGRMVLDRNPENYFAEVEQATFSPGTLVPGIDVSPDKMLQGRL FAYHDAHRYRVGANHQALPINRARNKVNNYQRDGQMRFDDNGGGSVYYEPNSFGGPKE SPEDKQAAYPVQGIADSVSYDHYDHYTQAGDLYRLMSEDERTRLVENIVNAMKPVEKE EIKLRQIEHFYKADPEYGKRVAEGLGLPIKKDS*" /label="katA CDS" gene complement(909112..910563) /gene="katA" /locus_tag="BSU_08820" /old_locus_tag="BSU08820" /label="katA gene" downshifts complement(909122) /Source="Nicolas_upshifts" /id="D450" /incds=0 /nref=221 /ntot=261 /MaxReadThrough="1.32399" /MaxDrop="8.8938" /score="25.1548262" /energy="-8.3" /TU="NA" /idTUdmin="U688" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 910540..910546 /Source="Nicolas_upshift_promotors" /id="U687" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.382617382617383" /psig="0.528471528471528" /xcortree=1222 /SigmaFactorBS="tgagttttgattatctccaaccggagcgccccagctAGTTGT CagtttatttgaactCATGTTATCACCTCTTGGAAtttataagaacataatatcatct c" /listShort="S309, ssuB, ssuA, ssuC, ssuD, ygaN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 910561..910580 /Source="Nicolas_upshift_promotors" /id="U687" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.382617382617383" /psig="0.528471528471528" /xcortree=1222 /SigmaFactorBS="tgagttttgattatctccaaccggagcgccccagctAGTTGT CagtttatttgaactCATGTTATCACCTCTTGGAAtttataagaacataatatcatct c" /listShort="S309, ssuB, ssuA, ssuC, ssuD, ygaN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 910564 /Source="Nicolas_upshifts" /id="U687" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.382617382617383" /psig="0.528471528471528" /xcortree=1222 /SigmaFactorBS="tgagttttgattatctccaaccggagcgccccagctAGTTGT CagtttatttgaactCATGTTATCACCTCTTGGAAtttataagaacataatatcatct c" /listShort="S309, ssuB, ssuA, ssuC, ssuD, ygaN" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(910581..910600) /Source="Nicolas_upshift_promotors" /id="U688" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=1533 /SigmaFactorBS="attaatagagataactattttataataattataaaataaTAT TGACTttttacttagagaTGATATTATGTTCTTATAAAttccaagaggtgataacatg a" /listShort="katA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 910586..910915 /Source="Nicolas_S_feature" /locus_tag="new_961009_961338" /HighExp="S8, C30, S7, S6, BT, C90, B36, S4, S5, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.528" /TUlongSig="NA" /TUlongPSig="NA" /label="S309" upshifts complement(910600) /Source="Nicolas_upshifts" /id="U688" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=1533 /SigmaFactorBS="attaatagagataactattttataataattataaaataaTAT TGACTttttacttagagaTGATATTATGTTCTTATAAAttccaagaggtgataacatg a" /listShort="katA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(910614..910621) /Source="Nicolas_upshift_promotors" /id="U688" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=1533 /SigmaFactorBS="attaatagagataactattttataataattataaaataaTAT TGACTttttacttagagaTGATATTATGTTCTTATAAAttccaagaggtgataacatg a" /listShort="katA" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(910659..910677) /Source="Nicolas_upshift_promotors" /id="U689" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.351648351648352" /psig="0.602397602397602" /xcortree=647 /SigmaFactorBS="gaaaaattatttctccaaaaattattaagtgtcataaaaagc tgttacaacaaggtttttcaacaatTTCGATACTATATATCGATtaatagagataact a" /listShort="katA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(910684) /Source="Nicolas_upshifts" /id="U689" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.351648351648352" /psig="0.602397602397602" /xcortree=647 /SigmaFactorBS="gaaaaattatttctccaaaaattattaagtgtcataaaaagc tgttacaacaaggtttttcaacaatTTCGATACTATATATCGATtaatagagataact a" /listShort="katA" /GFF_Attribute="listLong" /label="upshifts" downshifts 910872 /Source="Nicolas_upshifts" /id="D451" /incds=0 /nref=9 /ntot=21 /MaxReadThrough="5.89897" /MaxDrop="4.66837" /score="39.0049465" /energy="-19.7" /TU="U687" /idTUdmin="U686" /TUdmin=1936 /isTUend="FALSE" /label="downshifts" CDS 910971..911738 /gene="ssuB" /locus_tag="BSU_08830" /old_locus_tag="BSU08830" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9782504, 11390694, 16513748, 16885442; Product type t: transporter" /codon_start=1 /transl_table=11 /product="aliphatic sulfonate ABC transporter (ATP-bindingprotein)" /protein_id="NP_388763.3" /db_xref="EnsemblGenomes-Gn:BSU08830" /db_xref="EnsemblGenomes-Tr:CAB12711" /db_xref="GOA:P97027" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR017875" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12232" /db_xref="UniProtKB/Swiss-Prot:P97027" /translation="MAVTISIKEKAFVQEGRKNTVLENIELSIAPGEFLTLIGPSGCG KSTLLKIIAGLDSEYDGSVEINGRSVTAPGIQQGFIFQEHRLFPWLTVEQNIAADLNL KDPKVKQKVDELIEIVRLKGSEKAYPRELSGGMSQRVAIARALLREPEVLLLDEPFGA LDAFTRKHLQDVLLDIWRKKKTTMILVTHDIDESVYLGNELAILKAKPGKIHKLMPIH LAYPRNRTTPDFQAIRQRVLSEFEKTEDLEYAEGSGI*" /label="ssuB CDS" gene 910971..911738 /gene="ssuB" /locus_tag="BSU_08830" /old_locus_tag="BSU08830" /label="ssuB gene" CDS 911756..912754 /gene="ssuA" /locus_tag="BSU_08840" /old_locus_tag="BSU08840" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9782504, 11390694, 16513748, 16885442; Product type f: factor" /codon_start=1 /transl_table=11 /product="aliphatic sulfonate ABC transporter (binding lipoprotein)" /protein_id="NP_388764.1" /db_xref="EnsemblGenomes-Gn:BSU08840" /db_xref="EnsemblGenomes-Tr:CAB12712" /db_xref="GOA:P40400" /db_xref="InterPro:IPR001638" /db_xref="InterPro:IPR010067" /db_xref="InterPro:IPR015168" /db_xref="SubtiList:BG10656" /db_xref="UniProtKB/Swiss-Prot:P40400" /translation="MKKGLIVLVAVIFLLAGCGANGASGDHKQLKEIRIGIQQSLSPL LIAKEKGWFEDAFEKEGIKVKWVEFQSGPPQFEGLAADKLDFSQVGNSPVIAGQAAGI DFKEIGLSQDGLKANGILVNQNSGIQDVKGLKGKKIAVAKGSSGFDFLYKALDQVGLS ANDVTIIQLQPDEAASAFENGSVDAWSIWEPYLSLETMKHGAKILVNGESTDLYSPGF TLVRTKFSEEHPDEVVRFLKVFNKAVVWQKEHLDEAADLYSDIKDLDKKVVENVLKNT EPLNEIISDDIVKAQQETADFQFRTKAIDKKIDVKDVVDNTFIKKALEEHSSGGDQ*" /label="ssuA CDS" gene 911756..912754 /gene="ssuA" /locus_tag="BSU_08840" /old_locus_tag="BSU08840" /label="ssuA gene" CDS 912751..913581 /gene="ssuC" /locus_tag="BSU_08850" /old_locus_tag="BSU08850" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11390694, 15849754, 16513748, 16850406, 16885442, 9782504" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11390694, 15849754, 16513748, 16850406, 16885442, 9782504; Product type t : transporter" /codon_start=1 /transl_table=11 /product="aliphatic sulfonate ABC transporter (permease)" /protein_id="NP_388765.1" /db_xref="EnsemblGenomes-Gn:BSU08850" /db_xref="EnsemblGenomes-Tr:CAB12713" /db_xref="GOA:P40401" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG10657" /db_xref="UniProtKB/Swiss-Prot:P40401" /translation="MMKAEAAGSLPKTNAEAVRKKPGRKRYGWMKGLLLPAVIIAIWQ VIGGLGVVSATVLPTPVTIVLTFKELILSGELFGHLQISIYRAALGFLLGAGLGLMIG ILAGFSKRTELYLDPSLQMLRTVPHLAVTPLFILWFGFDEVSKILLIALGAFFPVYIN TFNGIRGVDAKLFEVARVLEFKWHQQISKVILPAALPNILLGIRLSLGIAWLGLVVAE LMGSSSGVGYMIMDARQFSQTNKVFAGIIIFAVVGKLTDSFVRLLERKLLKWRNSYEG *" /label="ssuC CDS" gene 912751..913581 /gene="ssuC" /locus_tag="BSU_08850" /old_locus_tag="BSU08850" /label="ssuC gene" CDS 913604..914734 /gene="ssuD" /locus_tag="BSU_08860" /old_locus_tag="BSU08860" /EC_number="1.14.14.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9782504, 11390694, 16513748, 16885442" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9782504, 11390694, 16513748, 16885442; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="FMNH2-dependent aliphatic sulfonate monooxygenase" /protein_id="NP_388766.2" /db_xref="EnsemblGenomes-Gn:BSU08860" /db_xref="EnsemblGenomes-Tr:CAB12714" /db_xref="GOA:P40402" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR019911" /db_xref="InterPro:IPR036661" /db_xref="SubtiList:BG10658" /db_xref="UniProtKB/Swiss-Prot:P40402" /translation="MEILWFIPTHGDARYLGSESDGRTADHLYFKQVAQAADRLGYTG VLLPTGRSCEDPWLTASALAGETKDLKFLVAVRPGLMQPSLAARMTSTLDRISDGRLL INVVAGGDPYELAGDGLFISHDERYEATDEFLTVWRRLLQGETVSYEGKHIKVENSNL LFPPQQEPHPPIYFGGSSQAGIEAAAKHTDVYLTWGEPPEQVKEKIERVKKQAAKEGR SVRFGIRLHVIARETEQEAWEAAERLISHLDDDTIAKAQAALSRYDSSGQQRMAVLHQ GDRTKLEISPNLWAGIGLVRGGAGTALVGDPQTIADRIAEYQALGIESFIFSGYPHLE EAYYFAELVFPLLPFENDRTRKLQNKRGEAVGNTYFVKEKNA*" /label="ssuD CDS" gene 913604..914734 /gene="ssuD" /locus_tag="BSU_08860" /old_locus_tag="BSU08860" /label="ssuD gene" misc_feature 914761..914780 /Source="Nicolas_upshift_promotors" /id="U690" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig="0.994005994005994" /xcortree=1467 /SigmaFactorBS="ttattttgtcaaagagaaaaatgcatgagtttaactaaaata cagccccccgaaCATGGTATGATATTCAAAAAaagggggctttttttctgaaaacatt g" /listShort="ygaN, S310" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 914767 /Source="Nicolas_upshifts" /id="U690" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig="0.994005994005994" /xcortree=1467 /SigmaFactorBS="ttattttgtcaaagagaaaaatgcatgagtttaactaaaata cagccccccgaaCATGGTATGATATTCAAAAAaagggggctttttttctgaaaacatt g" /listShort="ygaN, S310" /GFF_Attribute="listLong" /label="upshifts" CDS 914838..915374 /gene="ygaN" /locus_tag="BSU_08870" /old_locus_tag="BSU08870" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12193636, 16513748; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sulfur-related oxidoreductase" /protein_id="NP_388767.1" /db_xref="EnsemblGenomes-Gn:BSU08870" /db_xref="EnsemblGenomes-Tr:CAB12715" /db_xref="SubtiList:BG12233" /db_xref="UniProtKB/Swiss-Prot:P97028" /translation="MLSACGHSKQMEIKAADISDLEKNRMDVAASQAFTAEAVNIGEG ISSADMYIEHYQKGKLVERFGPVRADYSEEKTDTIQFVYFENEEGEGKNKHTTIHFGI VDKQGTIAADSSVKRDDSTTQEMTQNISSPEPITFEKPALIGSSIRGTDETMHTSEHK KELIKHQDALLYYVELHH*" /label="ygaN CDS" gene 914838..915374 /gene="ygaN" /locus_tag="BSU_08870" /old_locus_tag="BSU08870" /label="ygaN gene" S_feature 915375..915445 /Source="Nicolas_S_feature" /locus_tag="new_965798_965868" /HighExp="B36, BT, B60, Etha, S5, Heat, S2, BMM, S4, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.25357200000000002" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S310" promotor_-35 915415..915422 /Source="Nicolas_upshift_promotors" /id="U691" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=664 /SigmaFactorBS="caggccgtctgttttacaaagcggtatgCTTGCTTTtttgaa tggtgaaTGATACATTTTAAATCGTAAcaatttcgatttaaagggaggctatgtgact t" /listShort="rpsNB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 915436..915455 /Source="Nicolas_upshift_promotors" /id="U691" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=664 /SigmaFactorBS="caggccgtctgttttacaaagcggtatgCTTGCTTTtttgaa tggtgaaTGATACATTTTAAATCGTAAcaatttcgatttaaagggaggctatgtgact t" /listShort="rpsNB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 915447 /Source="Nicolas_upshifts" /id="U691" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=664 /SigmaFactorBS="caggccgtctgttttacaaagcggtatgCTTGCTTTtttgaa tggtgaaTGATACATTTTAAATCGTAAcaatttcgatttaaagggaggctatgtgact t" /listShort="rpsNB" /GFF_Attribute="listLong" /label="upshifts" CDS 915486..915755 /gene="rpsNB" /locus_tag="BSU_08880" /old_locus_tag="BSU08880" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12904577, 17163968, 19648245, 20208344, 27561249; Product type f: factor" /codon_start=1 /transl_table=11 /product="alternative ribosomal protein S14" /protein_id="NP_388768.1" /db_xref="EnsemblGenomes-Gn:BSU08880" /db_xref="EnsemblGenomes-Tr:CAB12716" /db_xref="GOA:O31587" /db_xref="InterPro:IPR001209" /db_xref="InterPro:IPR018271" /db_xref="InterPro:IPR023036" /db_xref="SubtiList:BG13085" /db_xref="UniProtKB/Swiss-Prot:O31587" /translation="MAKKSKVAKELKRQQLVEQYAGIRRELKEKGDYEALSKLPRDSA PGRLHNRCMVTGRPRAYMRKFKMSRIAFRELAHKGQIPGVKKASW*" /label="rpsNB CDS" gene 915486..915755 /gene="rpsNB" /locus_tag="BSU_08880" /old_locus_tag="BSU08880" /label="rpsNB gene" promotor_-35 915558..915562 /Source="Nicolas_upshift_promotors" /id="U692" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.62037962037962" /psig="0.020979020979021" /xcortree=654 /SigmaFactorBS="aatacgctggtattagaCGCGAgttgaaggaaaaaggagatt acGAGGCACTCAGCAAGCTgccaagagattcagcaccgggaaggcttcacaaccgctg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 915585..915601 /Source="Nicolas_upshift_promotors" /id="U692" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.62037962037962" /psig="0.020979020979021" /xcortree=654 /SigmaFactorBS="aatacgctggtattagaCGCGAgttgaaggaaaaaggagatt acGAGGCACTCAGCAAGCTgccaagagattcagcaccgggaaggcttcacaaccgctg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 915601 /Source="Nicolas_upshifts" /id="U692" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.62037962037962" /psig="0.020979020979021" /xcortree=654 /SigmaFactorBS="aatacgctggtattagaCGCGAgttgaaggaaaaaggagatt acGAGGCACTCAGCAAGCTgccaagagattcagcaccgggaaggcttcacaaccgctg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 915742 /Source="Nicolas_upshifts" /id="D452" /incds=0 /nref=41 /ntot=70 /MaxReadThrough="3.14088" /MaxDrop="6.23701" /score="18.4402235" /energy="-10.1" /TU="U692" /idTUdmin="U691" /TUdmin="-13" /isTUend="TRUE" /label="downshifts" CDS complement(915773..916246) /gene="ygaO" /locus_tag="BSU_08890" /old_locus_tag="BSU08890" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388769.1" /db_xref="EnsemblGenomes-Gn:BSU08890" /db_xref="EnsemblGenomes-Tr:CAB12717" /db_xref="GOA:P97029" /db_xref="SubtiList:BG12234" /db_xref="UniProtKB/Swiss-Prot:P97029" /translation="MSMKTKAAFHLVLFGLACWALISYFEASEGIASFFGTKSGGMVF DLNLTPFILFVAASAVYLYLQKKSRPARKQLLLPDEFEEQDEREQMMTAKACRASYIA VYFSLPAAAVLLIFYPLFQSRIPFFPIIIVFIIMIIQHLSYVISFKKNEKNSGAL*" /label="ygaO CDS" gene complement(915773..916246) /gene="ygaO" /locus_tag="BSU_08890" /old_locus_tag="BSU08890" /label="ygaO gene" downshifts complement(915809) /Source="Nicolas_upshifts" /id="D453" /incds=0 /nref=105 /ntot=235 /MaxReadThrough="1.59724" /MaxDrop="4.17785" /score="7.33161195" /energy="-10.1" /TU="NA" /idTUdmin="U693" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(916248..916448) /gene="ygzD" /locus_tag="BSU_08899" /old_locus_tag="BSU08899" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative HTH-type transcriptional regulator" /protein_id="YP_003097697.1" /db_xref="EnsemblGenomes-Gn:BSU08899" /db_xref="EnsemblGenomes-Tr:CAX52584" /db_xref="GOA:C0H3X9" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="UniProtKB/Swiss-Prot:C0H3X9" /translation="MKNKVKELRARFGYSQEKLGETVGVTRQTVAAIEKGDYVPSLLL ALKICKAFSMKMEDVFWLEEEN*" /label="ygzD CDS" gene complement(916248..916448) /gene="ygzD" /locus_tag="BSU_08899" /old_locus_tag="BSU08899" /label="ygzD gene" promotor_-10 complement(916477..916496) /Source="Nicolas_upshift_promotors" /id="U693" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.626373626373626" /psig="0.996003996003996" /xcortree=1780 /SigmaFactorBS="aaaaaaagttatctttttgtaaagttgttaagttcCATTTAC AtaatgttaagtaTACTATACAATATAATCAATcgagattgtgaaggggacagacgtc a" /listShort="ygzD, ygaO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(916491) /Source="Nicolas_upshifts" /id="U693" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.626373626373626" /psig="0.996003996003996" /xcortree=1780 /SigmaFactorBS="aaaaaaagttatctttttgtaaagttgttaagttcCATTTAC AtaatgttaagtaTACTATACAATATAATCAATcgagattgtgaaggggacagacgtc a" /listShort="ygzD, ygaO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(916509..916516) /Source="Nicolas_upshift_promotors" /id="U693" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.626373626373626" /psig="0.996003996003996" /xcortree=1780 /SigmaFactorBS="aaaaaaagttatctttttgtaaagttgttaagttcCATTTAC AtaatgttaagtaTACTATACAATATAATCAATcgagattgtgaaggggacagacgtc a" /listShort="ygzD, ygaO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 916572..916577 /Source="Nicolas_upshift_promotors" /id="U694" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.35964035964036" /psig=1 /xcortree=2589 /SigmaFactorBS="tacaaaaagataactttttttcgacaaaatttttatattccC TTGACgaaaaataaataaACATGTAATATAAAAAAAGTcagagcggtactgttgctga c" /listShort="trnSL-Gly1, S311, S312, yhbA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 916591..916610 /Source="Nicolas_upshift_promotors" /id="U694" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.35964035964036" /psig=1 /xcortree=2589 /SigmaFactorBS="tacaaaaagataactttttttcgacaaaatttttatattccC TTGACgaaaaataaataaACATGTAATATAAAAAAAGTcagagcggtactgttgctga c" /listShort="trnSL-Gly1, S311, S312, yhbA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 916591 /Source="Nicolas_upshifts" /id="U694" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.35964035964036" /psig=1 /xcortree=2589 /SigmaFactorBS="tacaaaaagataactttttttcgacaaaatttttatattccC TTGACgaaaaataaataaACATGTAATATAAAAAAAGTcagagcggtactgttgctga c" /listShort="trnSL-Gly1, S311, S312, yhbA" /GFF_Attribute="listLong" /label="upshifts" tRNA 916642..916715 /gene="trnSL-Gly1" /locus_tag="BSU_tRNA_82" /product="tRNA-Gly" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gly(TCC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Gly1 tRNA" gene 916642..916715 /gene="trnSL-Gly1" /locus_tag="BSU_tRNA_82" /label="trnSL-Gly1 gene" S_feature 916716..916898 /Source="Nicolas_S_feature" /locus_tag="new_967139_967321" /HighExp="G135, G180, Oxctl, G150, Paraq, H2O2, C30, HPh, LPh, LBGexp" /AntisenseName="yhzB" /AntisenseCor="0.42714037049296899" /AntisenseRegPval="-12.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S311" CDS complement(916806..917429) /gene="yhzB" /locus_tag="BSU_08900" /old_locus_tag="BSU08900" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388771.1" /db_xref="EnsemblGenomes-Gn:BSU08900" /db_xref="EnsemblGenomes-Tr:CAB12718" /db_xref="InterPro:IPR020825" /db_xref="SubtiList:BG13086" /db_xref="UniProtKB/Swiss-Prot:O31588" /translation="MNIKLDSVITERAAGLHAAAVIYENIEVGSSPQMLKGRLRLFQE SLFFDYADGGISDESFVKEWQKLFKQLNPSFEGETTPMEDMLVPISKEQFMESKDSAH DTIDFFALKYSLPIMIYDAGKLHEPVRISLGEKENILLFSDENGIFGDFKNSVNHYPV SNETKNMLQIIFFPPSIEKSSAVNLLSSLTKMFEQIHGGTHTVHWLT*" /label="yhzB CDS" gene complement(916806..917429) /gene="yhzB" /locus_tag="BSU_08900" /old_locus_tag="BSU08900" /label="yhzB gene" downshifts complement(916821) /Source="Nicolas_upshifts" /id="D454" /incds=0 /nref=25 /ntot=165 /MaxReadThrough="2.50849" /MaxDrop="4.62652" /score="-8.52782087" /energy="-7.9" /TU="NA" /idTUdmin="U695" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 916855 /Source="Nicolas_upshifts" /id="D455" /incds=0 /nref=1 /ntot=88 /MaxReadThrough="4.14204" /MaxDrop="2.36986" /score="16.0836885" /energy="-15.5" /TU="U694" /idTUdmin="U692" /TUdmin=1078 /isTUend="FALSE" /label="downshifts" S_feature 916900..917511 /Source="Nicolas_S_feature" /locus_tag="new_967323_967934" /HighExp="G180, G135, G150, Paraq, Oxctl, H2O2, LBGstat, Cold, LBGexp, S6" /AntisenseName="yhzB" /AntisenseCor="0.28959466335762701" /AntisenseRegPval="-5.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S312" promotor_-10 complement(917453..917472) /Source="Nicolas_upshift_promotors" /id="U695" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.631368631368631" /psig="0.999000999001" /xcortree=1953 /SigmaFactorBS="tctttgagctgataaacgttcatgttttgcacagcctccttT CTTTGTGataaaacgacacaGCGTTTATAATAGGTTGATAtcacgtaactggagtgaa t" /listShort="yhzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(917474) /Source="Nicolas_upshifts" /id="U695" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.631368631368631" /psig="0.999000999001" /xcortree=1953 /SigmaFactorBS="tctttgagctgataaacgttcatgttttgcacagcctccttT CTTTGTGataaaacgacacaGCGTTTATAATAGGTTGATAtcacgtaactggagtgaa t" /listShort="yhzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(917486..917493) /Source="Nicolas_upshift_promotors" /id="U695" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.631368631368631" /psig="0.999000999001" /xcortree=1953 /SigmaFactorBS="tctttgagctgataaacgttcatgttttgcacagcctccttT CTTTGTGataaaacgacacaGCGTTTATAATAGGTTGATAtcacgtaactggagtgaa t" /listShort="yhzB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 917512..918672 /gene="queG" /locus_tag="BSU_08910" /old_locus_tag="BSU08910" /EC_number="1.17.99.-" /function="10.3: tRNA and rRNA base modification" /experiment="publication(s) with functional evidences, PMID:8830270, 21502530, 26230193, 27638883, 28128549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8830270, 21502530, 26230193, 27638883, 28128549; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="epoxyqueuosine reductase" /protein_id="NP_388772.2" /db_xref="EnsemblGenomes-Gn:BSU08910" /db_xref="EnsemblGenomes-Tr:CAB12719" /db_xref="GOA:P97030" /db_xref="InterPro:IPR004155" /db_xref="InterPro:IPR004453" /db_xref="InterPro:IPR013542" /db_xref="InterPro:IPR016024" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR017900" /db_xref="PDB:5D08" /db_xref="PDB:5D0A" /db_xref="PDB:5D0B" /db_xref="PDB:5T8Y" /db_xref="SubtiList:BG12236" /db_xref="UniProtKB/Swiss-Prot:P97030" /translation="MNVYQLKEELIEYAKSIGVDKIGFTTADTFDSLKDRLILQESLG YLSGFEEPDIEKRVTPKLLLPKAKSIVAIALAYPSRMKDAPRSTRTERRGIFCRASWG KDYHDVLREKLDLLEDFLKSKHEDIRTKSMVDTGELSDRAVAERAGIGFSAKNCMITT PEYGSYVYLAEMITNIPFEPDVPIEDMCGSCTKCLDACPTGALVNPGQLNAQRCISFL TQTKGFLPDEFRTKIGNRLYGCDTCQTVCPLNKGKDFHLHPEMEPDPEIAKPLLKPLL AISNREFKEKFGHVSGSWRGKKPIQRNAILALAHFKDASALPELTELMHKDPRPVIRG TAAWAIGKIGDPAYAEELEKALEKEKDEEAKLEIEKGIELLKASGMTKQGLS*" /label="queG CDS" gene 917512..918672 /gene="queG" /locus_tag="BSU_08910" /old_locus_tag="BSU08910" /label="queG gene" downshifts 918681 /Source="Nicolas_upshifts" /id="D456" /incds=0 /nref=9 /ntot=123 /MaxReadThrough="5.29174" /MaxDrop="3.3561" /score="33.0421154" /energy="-15.1" /TU="NA" /idTUdmin="U694" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature 918698..918710 /Source="Nicolas_upshift_promotors" /id="U696" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.909090909090909" /psig="0.909090909090909" /xcortree=1143 /SigmaFactorBS="tcaggcatgactaaacaaggcctgtcctgacatacgtataga gcagaaggaaaaaACACTTGAGATCAtccaagtgttttttctctataaaaaagtatgg c" /listShort="yhbB, cspR" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 918703 /Source="Nicolas_upshifts" /id="U696" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.909090909090909" /psig="0.909090909090909" /xcortree=1143 /SigmaFactorBS="tcaggcatgactaaacaaggcctgtcctgacatacgtataga gcagaaggaaaaaACACTTGAGATCAtccaagtgttttttctctataaaaaagtatgg c" /listShort="yhbB, cspR" /GFF_Attribute="listLong" /label="upshifts" CDS 918739..919674 /gene="yhbB" /locus_tag="BSU_08920" /old_locus_tag="BSU08920" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388773.1" /db_xref="EnsemblGenomes-Gn:BSU08920" /db_xref="EnsemblGenomes-Tr:CAB12720" /db_xref="InterPro:IPR024301" /db_xref="SubtiList:BG11811" /db_xref="UniProtKB/Swiss-Prot:O31589" /translation="MAGGVSLKYILEQLAEERLGFLVNGHAMRQESQVGDLKVMERKK KLLEKRKVDIIKAKAKAVINHVRVEDDGTTCLSYTIHYEYVCKEQDDSLYIEEHIEER MAFLYDHILISDQEIAKKPAGFHEGTSIIDYSEAEEEREAFGRAFQYDRLGAVQYAEK FWNKRNPAYKNFSDNCTNFISQCLHAGGAPMRGHPNRGSGWWMKQSSWSYSWTVAHSM KMYLSNSKAGLRAVRVKSAEELMPGDVICYDFEGDGRFNHTTIVVAKDKGNMPLVNAQ TYDSRMRYWSYEDSTAYTPSIRYAFFHIVDDTTKE*" /label="yhbB CDS" gene 918739..919674 /gene="yhbB" /locus_tag="BSU_08920" /old_locus_tag="BSU08920" /label="yhbB gene" downshifts complement(918757) /Source="Nicolas_upshifts" /id="D457" /incds=0 /nref=2 /ntot=17 /MaxReadThrough="2.06584" /MaxDrop="3.33944" /score="-3.35852865" /energy="-6" /TU="NA" /idTUdmin="U695" /TUdmin="-1936" /isTUend="FALSE" /label="downshifts" promotor_-35 919658..919661 /Source="Nicolas_upshift_promotors" /id="U697" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.692307692307692" /psig=1 /xcortree=2502 /SigmaFactorBS="acacgccgtcaatacgatatgccttttttcatatcgttgatg ATACgacaaaagagtaattAATGTTATAATGATGGGCGGataagaaaaacagaggtga a" /listShort="cspR" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 919676 /Source="Nicolas_upshifts" /id="U697" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.692307692307692" /psig=1 /xcortree=2502 /SigmaFactorBS="acacgccgtcaatacgatatgccttttttcatatcgttgatg ATACgacaaaagagtaattAATGTTATAATGATGGGCGGataagaaaaacagaggtga a" /listShort="cspR" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 919677..919696 /Source="Nicolas_upshift_promotors" /id="U697" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.692307692307692" /psig=1 /xcortree=2502 /SigmaFactorBS="acacgccgtcaatacgatatgccttttttcatatcgttgatg ATACgacaaaagagtaattAATGTTATAATGATGGGCGGataagaaaaacagaggtga a" /listShort="cspR" /GFF_Attribute="listLong" /label="promotor_-10" CDS 919712..920194 /gene="trmL" /locus_tag="BSU_08930" /old_locus_tag="BSU08930" /EC_number="2.1.1.207" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 20855540; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA (cytidine(34)-2'-O)-methyltransferase" /protein_id="NP_388774.2" /db_xref="EnsemblGenomes-Gn:BSU08930" /db_xref="EnsemblGenomes-Tr:CAB12721" /db_xref="GOA:O31590" /db_xref="InterPro:IPR001537" /db_xref="InterPro:IPR016914" /db_xref="InterPro:IPR029026" /db_xref="InterPro:IPR029028" /db_xref="SubtiList:BG11802" /db_xref="UniProtKB/Swiss-Prot:O31590" /translation="MNIVALHVVLYQPEIPANTGNIARTCAATNTTLHLIRPLGFSTD DKMLKRAGLDYWEFVNVVYHDSLEELFEAYKKGKFFFITKFGQQPHTSFDYTDLDEDY FFVFGRETSGLPKDLIQNNMDRCLRLPMTEHVRSLNLSNTAAILVYEALRQQNYRDLK *" /label="trmL CDS" gene 919712..920194 /gene="trmL" /locus_tag="BSU_08930" /old_locus_tag="BSU08930" /label="trmL gene" downshifts 920177 /Source="Nicolas_upshifts" /id="D458" /incds=0 /nref=203 /ntot=259 /MaxReadThrough="4.6846" /MaxDrop="7.03587" /score="33.0421154" /energy="-15.1" /TU="NA" /idTUdmin="U696" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 920244..920960 /gene="yhbD" /locus_tag="BSU_08940" /old_locus_tag="BSU08940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative sporulation-related protein" /protein_id="NP_388775.1" /db_xref="EnsemblGenomes-Gn:BSU08940" /db_xref="EnsemblGenomes-Tr:CAB12722" /db_xref="InterPro:IPR025063" /db_xref="SubtiList:BG12237" /db_xref="UniProtKB/Swiss-Prot:P97032" /translation="MLCFVFGLNNVTVLCYNVPIKGAGLMEEQLISKKELLERTSISY GQLYRWKRKNLIPEEWFIRKSTFTGQETFFPREEILKRISMIQKMKENLSLDEMREML SPKMKDVSMTADELLHKGLVSRPALEAYSEDGGSPVFSSSDLLSLFVLEGLLQSGNVS LAEAKMAAEVLKKHDTEEIEKQTELIVLRKLGVTTCFIAAAADSILFESSVKVVERVD LLKASEELKTTFMQEGHQWM*" /label="yhbD CDS" gene 920244..920960 /gene="yhbD" /locus_tag="BSU_08940" /old_locus_tag="BSU08940" /label="yhbD gene" promotor_-35 920264..920271 /Source="Nicolas_upshift_promotors" /id="U698" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.761238761238761" /psig=1 /xcortree=2394 /SigmaFactorBS="tttttgcggatgttgaaatgctttgtttcgtttttggGCTTA ACAacgtaacagtgttaTGTTACAATGTACCCATCAAaggagctggacttatggaaga a" /listShort="yhbD, yhbE, yhbF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 920286..920305 /Source="Nicolas_upshift_promotors" /id="U698" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.761238761238761" /psig=1 /xcortree=2394 /SigmaFactorBS="tttttgcggatgttgaaatgctttgtttcgtttttggGCTTA ACAacgtaacagtgttaTGTTACAATGTACCCATCAAaggagctggacttatggaaga a" /listShort="yhbD, yhbE, yhbF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 920287 /Source="Nicolas_upshifts" /id="U698" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.761238761238761" /psig=1 /xcortree=2394 /SigmaFactorBS="tttttgcggatgttgaaatgctttgtttcgtttttggGCTTA ACAacgtaacagtgttaTGTTACAATGTACCCATCAAaggagctggacttatggaaga a" /listShort="yhbD, yhbE, yhbF" /GFF_Attribute="listLong" /label="upshifts" CDS 920951..921664 /gene="yhbE" /locus_tag="BSU_08950" /old_locus_tag="BSU08950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12562816, 20617312; Product type cp:cell process" /codon_start=1 /transl_table=11 /product="conserved protein involved in sporulation" /protein_id="NP_388776.1" /db_xref="EnsemblGenomes-Gn:BSU08950" /db_xref="EnsemblGenomes-Tr:CAB12723" /db_xref="InterPro:IPR007607" /db_xref="SubtiList:BG10802" /db_xref="UniProtKB/Swiss-Prot:P39132" /translation="MDVVEKLVINGSGSSKGGTFQSVEINGSGTVAGDVECDTFSFNG NGKADGSVKAKAVTISGSGKIHGDVEAESIRMNGTGFIQGEVSAKQLKIAGSSTFGGT VKADGIDISGKAVMEADCETETFQSEGKCKISGLLNADQVIIKLSAGESYAREIGCRH LQVTCRKGMLTLLRLMPQPVLTAELIEGDVIELTNTKAKTVRGNKVIIGPDCQIETVE YSGDYTCDPSASVETSTKL*" /label="yhbE CDS" gene 920951..921664 /gene="yhbE" /locus_tag="BSU_08950" /old_locus_tag="BSU08950" /label="yhbE gene" CDS 921676..922383 /gene="yhbF" /locus_tag="BSU_08960" /old_locus_tag="BSU08960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12562816, 20617312; Product type cp:cell process" /codon_start=1 /transl_table=11 /product="conserved protein involved in sporulation" /protein_id="NP_388777.2" /db_xref="EnsemblGenomes-Gn:BSU08960" /db_xref="EnsemblGenomes-Tr:CAB12724" /db_xref="SubtiList:BG10803" /db_xref="UniProtKB/Swiss-Prot:P39133" /translation="METTKLGNLKLYGAGHAAGGAYHNVSIKGEGIVGEGLSAVGCRI YGTGLFLGKAETERLRVLGESECKGDLTAGKINIYGTMKVSGSLQFDRFNLKGQTEIG GNMTGESCDVKGKLSVIGDCETEMFHVTGCVDVSGLLNSGEIKLGLSHDISHVQEIGG TTITVKRRASFFSRKKGKLIADVIEGDRVYLENTEAAVVRGKEVIIGPGCSIGTIEYE YKCECDPHSQIKEKTKL*" /label="yhbF CDS" gene 921676..922383 /gene="yhbF" /locus_tag="BSU_08960" /old_locus_tag="BSU08960" /label="yhbF gene" downshifts 922267 /Source="Nicolas_upshifts" /id="D459" /incds=1 /nref=1 /ntot=127 /MaxReadThrough="4.34704" /MaxDrop="2.64409" /score="45.497414" /energy="-15.3" /TU="U698" /idTUdmin="U698" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" downshifts 922311 /Source="Nicolas_upshifts" /id="D460" /incds=1 /nref=2 /ntot=35 /MaxReadThrough="4.02504" /MaxDrop="3.21894" /score="45.497414" /energy="-15.3" /TU="U698" /idTUdmin="U698" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" downshifts 922377 /Source="Nicolas_upshifts" /id="D461" /incds=0 /nref=2 /ntot=41 /MaxReadThrough="1.06365" /MaxDrop="3.74046" /score="45.497414" /energy="-15.3" /TU="NA" /idTUdmin="U698" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(922410..922585) /Source="Nicolas_S_feature" /locus_tag="new_972833_973008_c" /HighExp="M9-stat, BC, S4, T0.30H, LoTm, Lbstat, S2, BT, HiOs, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99846699999999999" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S313" downshifts complement(922453) /Source="Nicolas_upshifts" /id="D462" /incds=0 /nref=63 /ntot=220 /MaxReadThrough="3.38525" /MaxDrop="4.33005" /score="18.2489321" /energy="-13.5" /TU="U699" /idTUdmin="U699" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(922577..922596) /Source="Nicolas_upshift_promotors" /id="U699" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.653346653346653" /psig="0.998001998001998" /xcortree=456 /SigmaFactorBS="tttcttaaaaataaagatactcatacaTCGTTGACaaggcag actgcgaCCGTTCATAATAAAGAAAAAtacagaatcatccagactcggacagcacgga a" /listShort="S313" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(922585) /Source="Nicolas_upshifts" /id="U699" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.653346653346653" /psig="0.998001998001998" /xcortree=456 /SigmaFactorBS="tttcttaaaaataaagatactcatacaTCGTTGACaaggcag actgcgaCCGTTCATAATAAAGAAAAAtacagaatcatccagactcggacagcacgga a" /listShort="S313" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(922611..922618) /Source="Nicolas_upshift_promotors" /id="U699" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.653346653346653" /psig="0.998001998001998" /xcortree=456 /SigmaFactorBS="tttcttaaaaataaagatactcatacaTCGTTGACaaggcag actgcgaCCGTTCATAATAAAGAAAAAtacagaatcatccagactcggacagcacgga a" /listShort="S313" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 922650..922655 /Source="Nicolas_upshift_promotors" /id="U700" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1094 /SigmaFactorBS="gtcaacgatgtatgagtatctttatttttaagaaaccaaAGC ATGtatcacgagatggcgGCATAGATTGTATCAAAGTaccttatttgcatagtgtatc a" /listShort="prkA, S314, yhbH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 922671..922689 /Source="Nicolas_upshift_promotors" /id="U700" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1094 /SigmaFactorBS="gtcaacgatgtatgagtatctttatttttaagaaaccaaAGC ATGtatcacgagatggcgGCATAGATTGTATCAAAGTaccttatttgcatagtgtatc a" /listShort="prkA, S314, yhbH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 922671 /Source="Nicolas_upshifts" /id="U700" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1094 /SigmaFactorBS="gtcaacgatgtatgagtatctttatttttaagaaaccaaAGC ATGtatcacgagatggcgGCATAGATTGTATCAAAGTaccttatttgcatagtgtatc a" /listShort="prkA, S314, yhbH" /GFF_Attribute="listLong" /label="upshifts" CDS 922733..924628 /gene="prkA" /locus_tag="BSU_08970" /old_locus_tag="BSU08970" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8626065, 12662922, 25983726, 27806131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8626065, 12662922, 25983726, 27806131; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="serine protein kinase (involved in sporulation)" /protein_id="NP_388778.1" /db_xref="EnsemblGenomes-Gn:BSU08970" /db_xref="EnsemblGenomes-Tr:CAB12725" /db_xref="GOA:P39134" /db_xref="InterPro:IPR010650" /db_xref="InterPro:IPR013153" /db_xref="InterPro:IPR016230" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10804" /db_xref="UniProtKB/Swiss-Prot:P39134" /translation="MDILKKIEKYREEEQRLKWEGTFADYLEIIKENPMVAQSAHSRV FNMIKDSGIEEIDGRKKYSFFDRELFGLEESLERLVEEYFHPAAKRLDVRKRILLLMG PVSGGKSTLVTMLKKGLEAYTLTDNGAVYAIKGCPMHEDPLHLIPHHLRDDFYREYGI RIEGSLSPLNVMRLEEEYGGRIEDVKVERIFFSEDKRTGIGTFSPSDPKSQDIADLTG SIDFSTIAEYGSESDPRAYRFDGELNKANRGMMEFQEMLKCDEKFLWHLLSLTQEGNF KAGRFALISADELIVAHTNETEYRSFISNKKNEALHSRIIVMPVPYNLKVSEEERIYE KMIAESDVADVHIAPHTLKVAAMFSILTRLKEPKRSDIDLVKKMRLYDGESVEGYNSV DVEDMKKEYNDEGMSGIDPRYVINRISSTIIRKNMESINSLDVLRSLKEGLDQHPSIS SEDRERYLNFISAARKEYDDIAKKEVQKAFVYSYEESAKTLMDNYLDNVEAYCNKNKL RDPLTGEEMNPDEKLMRSIEEQIGISENAKKAFREEILIRISAYARKGKRFDYNSHER LREAIQKKLFADLKDVVKITTSTKTPDEQQLKKVNEVVARLIDEHGYNSTSANELLKY VGSLLNR*" /label="prkA CDS" gene 922733..924628 /gene="prkA" /locus_tag="BSU_08970" /old_locus_tag="BSU08970" /label="prkA gene" promotor_no_box 923175..923275 /Source="Nicolas_upshift_promotors" /id="U701" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.31968031968032" /psig="0.31968031968032" /xcortree=684 /SigmaFactorBS="atcatttacgcgatgacttttacagagaatacggcattagaa tagaaggaagtctttctcctttaaatgtcatgaggctggaggaagagtacggaggaag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 923235 /Source="Nicolas_upshifts" /id="U701" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.31968031968032" /psig="0.31968031968032" /xcortree=684 /SigmaFactorBS="atcatttacgcgatgacttttacagagaatacggcattagaa tagaaggaagtctttctcctttaaatgtcatgaggctggaggaagagtacggaggaag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 923301 /Source="Nicolas_upshifts" /id="D463" /incds=1 /nref=5 /ntot=18 /MaxReadThrough="7.33384" /MaxDrop="5.65132" /score="45.497414" /energy="-15.3" /TU="U700" /idTUdmin="U701" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 924621 /Source="Nicolas_upshifts" /id="D464" /incds=0 /nref=11 /ntot=57 /MaxReadThrough="6.19375" /MaxDrop="4.381" /score="-0.497429548" /energy="-10.6" /TU="U700" /idTUdmin="U703" /TUdmin="-528" /isTUend="FALSE" /label="downshifts" promotor_-35 924685..924690 /Source="Nicolas_upshift_promotors" /id="U702" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1058 /SigmaFactorBS="agggcgggttattttgtcccattttctaaatagtttGTCAAT taaacgtgcatatgtGCATATGATGAATATAAATcttttcaaaagacttgtttcataa t" /listShort="S314, yhbH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 924706..924724 /Source="Nicolas_upshift_promotors" /id="U702" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1058 /SigmaFactorBS="agggcgggttattttgtcccattttctaaatagtttGTCAAT taaacgtgcatatgtGCATATGATGAATATAAATcttttcaaaagacttgtttcataa t" /listShort="S314, yhbH" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 924709..924807 /Source="Nicolas_S_feature" /locus_tag="new_975132_975230" /HighExp="S6, S7, S5, S8, S4, S3, BT, LoTm, B36, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigEF" /TUshortPSig="0.971, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S314" upshifts 924709 /Source="Nicolas_upshifts" /id="U702" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1058 /SigmaFactorBS="agggcgggttattttgtcccattttctaaatagtttGTCAAT taaacgtgcatatgtGCATATGATGAATATAAATcttttcaaaagacttgtttcataa t" /listShort="S314, yhbH" /GFF_Attribute="listLong" /label="upshifts" CDS 924808..925986 /gene="yhbH" /locus_tag="BSU_08980" /old_locus_tag="BSU08980" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11988534, 12662922, 14523133, 25983726" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11988534, 12662922, 14523133, 25983726; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor involved in shape determination" /protein_id="NP_388779.1" /db_xref="EnsemblGenomes-Gn:BSU08980" /db_xref="EnsemblGenomes-Tr:CAB12726" /db_xref="InterPro:IPR006698" /db_xref="InterPro:IPR014230" /db_xref="SubtiList:BG11238" /db_xref="UniProtKB/Swiss-Prot:P45742" /translation="MSQNDSGHFLISEENWSLHRKGFDDQQRHQKKVQEAIKNNLPDL VTEESIIMSNGKDVVKIPIRSLDEYKIRYNYDKNKHVGQGDGESQVGDVVARDGSDKK QGPGKGQGAGDQAGEDYYEAEVSLMDLEEALFKELELPNLQQKERDNIIHTDIEFNDI RKTGLTGNIDKKRTMMSAFKRNAMSGKPSFYPIYPEDLKYKTWNDITKPESKAVVLAM MDTSGSMGVWEKYMARSFFFWMTRFLRTKYETVEIEFIAHHTEARVVSEEDFFSKGES GGTICSSVYRKSLELIDEKYNPARYNIYPFHFSDGDNLTSDNARCVKLVNDIMKKANL FCYGEVNQYNRHSTLMSAYKNVKDEKFKYYILKQKSDVFQALKNFFRNEESGVSHQFS *" /label="yhbH CDS" gene 924808..925986 /gene="yhbH" /locus_tag="BSU_08980" /old_locus_tag="BSU08980" /label="yhbH gene" promotor_-35 925006..925009 /Source="Nicolas_upshift_promotors" /id="U703" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.367632367632368" /psig="0.985014985014985" /xcortree=615 /SigmaFactorBS="atggaaaagatgtagtgaagatcccaatccgttcacttGATG agtataaaatccgtTATAACTATGATAAAAATAAacatgtagggcaaggagacggcga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 925024..925043 /Source="Nicolas_upshift_promotors" /id="U703" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.367632367632368" /psig="0.985014985014985" /xcortree=615 /SigmaFactorBS="atggaaaagatgtagtgaagatcccaatccgttcacttGATG agtataaaatccgtTATAACTATGATAAAAATAAacatgtagggcaaggagacggcga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 925028 /Source="Nicolas_upshifts" /id="U703" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.367632367632368" /psig="0.985014985014985" /xcortree=615 /SigmaFactorBS="atggaaaagatgtagtgaagatcccaatccgttcacttGATG agtataaaatccgtTATAACTATGATAAAAATAAacatgtagggcaaggagacggcga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(925269) /Source="Nicolas_upshifts" /id="D465" /incds=1 /nref=1 /ntot=23 /MaxReadThrough="2.79078" /MaxDrop="2.94521" /score="-7.1109433" /energy="-11.2" /TU="NA" /idTUdmin="U699" /TUdmin="-3014" /isTUend="FALSE" /label="downshifts" downshifts 925965 /Source="Nicolas_upshifts" /id="D466" /incds=0 /nref=63 /ntot=180 /MaxReadThrough="1.86673" /MaxDrop="8.19565" /score="27.3980811" /energy="-5.6" /TU="NA" /idTUdmin="U702" /TUdmin=2 /isTUend="TRUE" /label="downshifts" promotor_-35 926073..926080 /Source="Nicolas_upshift_promotors" /id="U704" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.754245754245754" /psig="0.996003996003996" /xcortree=2450 /SigmaFactorBS="cgcttgcgaaaaaaatacgggagaaaaagaaatttttcCTTT GACAaatcttctttcattTATTAATATTTTATCTTGTGaactattattgaggaatgag g" /listShort="yhbI, yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 926095..926114 /Source="Nicolas_upshift_promotors" /id="U704" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.754245754245754" /psig="0.996003996003996" /xcortree=2450 /SigmaFactorBS="cgcttgcgaaaaaaatacgggagaaaaagaaatttttcCTTT GACAaatcttctttcattTATTAATATTTTATCTTGTGaactattattgaggaatgag g" /listShort="yhbI, yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 926095 /Source="Nicolas_upshifts" /id="U704" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.754245754245754" /psig="0.996003996003996" /xcortree=2450 /SigmaFactorBS="cgcttgcgaaaaaaatacgggagaaaaagaaatttttcCTTT GACAaatcttctttcattTATTAATATTTTATCTTGTGaactattattgaggaatgag g" /listShort="yhbI, yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="upshifts" CDS 926146..926610 /gene="yhbI" /locus_tag="BSU_08990" /old_locus_tag="BSU08990" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20011599; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)induced by acid stress" /protein_id="NP_388780.1" /db_xref="EnsemblGenomes-Gn:BSU08990" /db_xref="EnsemblGenomes-Tr:CAB12727" /db_xref="GOA:O31592" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13003" /db_xref="UniProtKB/Swiss-Prot:O31592" /translation="MTESERALLTFEQLFDTSRAIYKKQKKILEIVLEPFDITVLQYL LMFKIHQSGSTPLSKLAMSLDLKPASVTRMTDILYKRQLMNRYDSPDDRRIVMIQLTE EGEELIEKAAVQYAKMGAGLYQKLDTSQLQYLRKLAGSLTKLAEGCSEKSGN*" /label="yhbI CDS" gene 926146..926610 /gene="yhbI" /locus_tag="BSU_08990" /old_locus_tag="BSU08990" /label="yhbI gene" promotor_-35 926435..926441 /Source="Nicolas_upshift_promotors" /id="U705" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.94005994005994" /psig="0.94005994005994" /xcortree=270 /SigmaFactorBS="cagtccggatgaccgccgtatcgtcaTGATTCAgttaaccga agaggGGGAAGAACTGATAGAAAAagccgctgtgcaatatgcaaaaatgggtgctggc t" /listShort="yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 926456..926474 /Source="Nicolas_upshift_promotors" /id="U705" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.94005994005994" /psig="0.94005994005994" /xcortree=270 /SigmaFactorBS="cagtccggatgaccgccgtatcgtcaTGATTCAgttaaccga agaggGGGAAGAACTGATAGAAAAagccgctgtgcaatatgcaaaaatgggtgctggc t" /listShort="yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 926469 /Source="Nicolas_upshifts" /id="U705" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.94005994005994" /psig="0.94005994005994" /xcortree=270 /SigmaFactorBS="cagtccggatgaccgccgtatcgtcaTGATTCAgttaaccga agaggGGGAAGAACTGATAGAAAAagccgctgtgcaatatgcaaaaatgggtgctggc t" /listShort="yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 926619..926625 /Source="Nicolas_upshift_promotors" /id="U706" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=808 /SigmaFactorBS="gctgttcagaaaaaagcggtaattaaaaacttctCACATATt ttcaccagctttCCGCAAAATGATagaggatgaaacgaaaggagaaaacaaaatgaac a" /listShort="yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 926639..926650 /Source="Nicolas_upshift_promotors" /id="U706" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=808 /SigmaFactorBS="gctgttcagaaaaaagcggtaattaaaaacttctCACATATt ttcaccagctttCCGCAAAATGATagaggatgaaacgaaaggagaaaacaaaatgaac a" /listShort="yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 926645 /Source="Nicolas_upshifts" /id="U706" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=808 /SigmaFactorBS="gctgttcagaaaaaagcggtaattaaaaacttctCACATATt ttcaccagctttCCGCAAAATGATagaggatgaaacgaaaggagaaaacaaaatgaac a" /listShort="yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="upshifts" CDS 926646..927311 /gene="yhbJ" /locus_tag="BSU_09000" /old_locus_tag="BSU09000" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 20011599; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane fusion protein; putative exporter subunit (benzoate transcriptome)" /protein_id="NP_388781.1" /db_xref="EnsemblGenomes-Gn:BSU09000" /db_xref="EnsemblGenomes-Tr:CAB12728" /db_xref="GOA:O31593" /db_xref="InterPro:IPR011053" /db_xref="SubtiList:BG13004" /db_xref="UniProtKB/Swiss-Prot:O31593" /translation="MIEDETKGENKMNRGRLILTNIIGLIVVLAIIAGGAYYYYQSTN YVKTDEAKVAGDMAAITAPAAGKVSDWDLDEGKTVKKGDTVAKIKGEQTVDVKSIMDG TIVKNEVKNGQTVQAGTTIAQTIDMDNLYITANIKETDIADIEVGNSVDVVVDGDPDT TFDGTVEEIGYATNSTFDMLPSTNSSGNYTKVTQKVPVKISIKNPSDKVLPGMNASVK ISE*" /label="yhbJ CDS" gene 926646..927311 /gene="yhbJ" /locus_tag="BSU_09000" /old_locus_tag="BSU09000" /label="yhbJ gene" CDS 927352..928950 /gene="yhcA" /locus_tag="BSU_09010" /old_locus_tag="BSU09010" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 20011599; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative exporter (benzoate transcriptome)" /protein_id="NP_388782.1" /db_xref="EnsemblGenomes-Gn:BSU09010" /db_xref="EnsemblGenomes-Tr:CAB12729" /db_xref="GOA:P54585" /db_xref="InterPro:IPR004638" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11579" /db_xref="UniProtKB/Swiss-Prot:P54585" /translation="MATGKEKNAKNPMSLLIVLMAGLFLAILNQTLLNVAMPHLMTEF GVSATTIQWLTTGYMLVNGVLIPLSAFLITRFGQRSLFLVAMFCFTLGTLVCGIAPNF STMLIGRLIQAVGGGILQPLVMTTILLIFPPESRGKGMGIFGLAMMFAPAVGPTLSGW IIEHYTWRIMFYGLVPIGAIVIIVAFFIFKNMVEPQKIKLDTLGAILSIVGFASLLYG VSEAGSDGWTDPIVLSTVIIGAIAIVAFVVQQLRHDDPMLDFRVFKYDIFSLSSVINI IITVALYTGMFLLPIYLQNLVGFTALQSGLLLLPGAIVMLIMSPISGILFDKFGPRPL AIIGLLVTVVTTYQYTQLTIDTPYTHIMLIYSIRAFGMSLLMMPVMTAGMNQLPARLN SHGTAMSNTLRQISGSIGTSLITTIYTNRTTFHYSQIADKTSTADPNFLHAFQNAVSN LMVNMNVSYDTAKTYVYSHIYKHASLDSNVMGINDAFMWATLFCVAGLILSIFLRDVR KDKLRKKKKEELSLLPAPKEAKES*" /label="yhcA CDS" gene 927352..928950 /gene="yhcA" /locus_tag="BSU_09010" /old_locus_tag="BSU09010" /label="yhcA gene" CDS 928973..929503 /gene="yhcB" /locus_tag="BSU_09020" /old_locus_tag="BSU09020" /EC_number="1.6.5.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15754243, 18041955, 17951395, 19665595, 20011599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADH:quinone oxidoreductase associated to benzoate stress" /protein_id="NP_388783.1" /db_xref="EnsemblGenomes-Gn:BSU09020" /db_xref="EnsemblGenomes-Tr:CAB12730" /db_xref="GOA:P54586" /db_xref="InterPro:IPR005025" /db_xref="InterPro:IPR008254" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG11580" /db_xref="UniProtKB/Swiss-Prot:P54586" /translation="MKIYVVYDSEGEHTKVLAEAIAEGARENDAAEVFIDHVDQADIR KLKDMDAIIWGCPGHFGTISSGLKTWIDRLGYLWAEGELINKVGAVFCTTATTHGGLE MTMHNLITPMFHQGMIVVGLPGNVPENALYGSYYGAGVTCPVDSDELMSEEGIQLGRA LGRRVSQVTGNLTAGQ*" /label="yhcB CDS" gene 928973..929503 /gene="yhcB" /locus_tag="BSU_09020" /old_locus_tag="BSU09020" /label="yhcB gene" CDS 929516..929890 /gene="yhcC" /locus_tag="BSU_09030" /old_locus_tag="BSU09030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical membrane protein" /protein_id="NP_388784.1" /db_xref="EnsemblGenomes-Gn:BSU09030" /db_xref="EnsemblGenomes-Tr:CAB12731" /db_xref="GOA:P54587" /db_xref="SubtiList:BG11581" /db_xref="UniProtKB/Swiss-Prot:P54587" /translation="MAIIIAIIAAVIVIAALITFNVRNASPGPEKQEATDRIAPPEEE KNEAHYPAEARAAEHTPSVVKNDSPKEKRDTMGDDIYRQALQKFKHSDEVHAEEEVTE ESDKMQDRSYRDALLSMKNKKK*" /label="yhcC CDS" gene 929516..929890 /gene="yhcC" /locus_tag="BSU_09030" /old_locus_tag="BSU09030" /label="yhcC gene" downshifts 929879 /Source="Nicolas_upshifts" /id="D467" /incds=0 /nref=32 /ntot=145 /MaxReadThrough="1.78742" /MaxDrop="5.9171" /score="13.777309" /energy="-14.4" /TU="NA" /idTUdmin="U704" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 929890..930045 /gene="yhcD" /locus_tag="BSU_09040" /old_locus_tag="BSU09040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388785.1" /db_xref="EnsemblGenomes-Gn:BSU09040" /db_xref="EnsemblGenomes-Tr:CAB12732" /db_xref="SubtiList:BG11582" /db_xref="UniProtKB/Swiss-Prot:P54588" /translation="MKKANPFTHAGLPFLLFPSIMFLSNKSMEYVVFHLDLVYYVTHT PRIFSGR*" /label="yhcD CDS" gene 929890..930045 /gene="yhcD" /locus_tag="BSU_09040" /old_locus_tag="BSU09040" /label="yhcD gene" promotor_-35 929980..929986 /Source="Nicolas_upshift_promotors" /id="U707" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.571428571428571" /psig=1 /xcortree=2541 /SigmaFactorBS="tgtttttatcaaataaatccatggaatatGTTGTATtccacc ttgatctaGTGTACTATGTTACTCATACaccgaggattttttccgggaggtaaagaca t" /listShort="yhcE, yhcF, yhcG, yhcH, yhcI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 930001..930020 /Source="Nicolas_upshift_promotors" /id="U707" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.571428571428571" /psig=1 /xcortree=2541 /SigmaFactorBS="tgtttttatcaaataaatccatggaatatGTTGTATtccacc ttgatctaGTGTACTATGTTACTCATACaccgaggattttttccgggaggtaaagaca t" /listShort="yhcE, yhcF, yhcG, yhcH, yhcI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 930011 /Source="Nicolas_upshifts" /id="U707" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.571428571428571" /psig=1 /xcortree=2541 /SigmaFactorBS="tgtttttatcaaataaatccatggaatatGTTGTATtccacc ttgatctaGTGTACTATGTTACTCATACaccgaggattttttccgggaggtaaagaca t" /listShort="yhcE, yhcF, yhcG, yhcH, yhcI" /GFF_Attribute="listLong" /label="upshifts" CDS 930050..930811 /gene="yhcE" /locus_tag="BSU_09050" /old_locus_tag="BSU09050" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane orphan protein" /protein_id="NP_388786.1" /db_xref="EnsemblGenomes-Gn:BSU09050" /db_xref="EnsemblGenomes-Tr:CAB12733" /db_xref="GOA:P54589" /db_xref="SubtiList:BG11583" /db_xref="UniProtKB/Swiss-Prot:P54589" /translation="MNSFLGLLKKDIKLSRMWLLVWICGIIFLLGTGHIIASRTKEPL VIFGFFVAVAFFLLFLSPVFVFYHLRKEGKSQLWLYNPNGGLWLFSSKLAASLLYQFV IQLALTAYGIWMYHMLSVKNLLEHQVDITSTVALLNMYGLISSLDMSVTVIVFWTVFH SLRNWRGMRWAAMVLLVAMWLFFDEYIISPLVESQKHFWPVTVYCNFDFHFHNVWRLE LKPIHLSVLGFPIAIVITFLLLIMASKLLDRKVEV*" /label="yhcE CDS" gene 930050..930811 /gene="yhcE" /locus_tag="BSU_09050" /old_locus_tag="BSU09050" /label="yhcE gene" promotor_-10 complement(930363..930381) /Source="Nicolas_upshift_promotors" /id="U708" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1187 /SigmaFactorBS="tatcaacttgatgctccagcagattttttacagagAGCATAt gatacatccatatgCCATAGGCTGTTAATGCCAactgaatcacaaattgatagagcaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(930377) /Source="Nicolas_upshifts" /id="U708" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1187 /SigmaFactorBS="tatcaacttgatgctccagcagattttttacagagAGCATAt gatacatccatatgCCATAGGCTGTTAATGCCAactgaatcacaaattgatagagcaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(930397..930402) /Source="Nicolas_upshift_promotors" /id="U708" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1187 /SigmaFactorBS="tatcaacttgatgctccagcagattttttacagagAGCATAt gatacatccatatgCCATAGGCTGTTAATGCCAactgaatcacaaattgatagagcaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 930814..931179 /gene="yhcF" /locus_tag="BSU_09060" /old_locus_tag="BSU09060" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (GntR family)" /protein_id="NP_388787.1" /db_xref="EnsemblGenomes-Gn:BSU09060" /db_xref="EnsemblGenomes-Tr:CAB12734" /db_xref="GOA:P54590" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11584" /db_xref="UniProtKB/Swiss-Prot:P54590" /translation="MDNQFQSSKPIYLQIADQIFYRLVRKELLPGDKLPSVREMAIQT KVNPNTIQRTYSEMERLGIVETRRGQGTFIAEKAEIVDELKDKLTREVLEGFVKQMKE LGLTKEEMLEGIKTFTEGG*" /label="yhcF CDS" gene 930814..931179 /gene="yhcF" /locus_tag="BSU_09060" /old_locus_tag="BSU09060" /label="yhcF gene" CDS 931181..931879 /gene="yhcG" /locus_tag="BSU_09070" /old_locus_tag="BSU09070" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15870467; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter ATP-binding protein" /protein_id="NP_388788.1" /db_xref="EnsemblGenomes-Gn:BSU09070" /db_xref="EnsemblGenomes-Tr:CAB12735" /db_xref="GOA:P54591" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11585" /db_xref="UniProtKB/Swiss-Prot:P54591" /translation="MEIKLEHVSKKYGRHTAVNDVSITLSSGRIYGLIGPNGSGKSTT LKMMAGLLFPTSGFVKVDEEQVTREMVRQTAYLTELDMFYPHFTVKDMVNFYQSQFPD FHTEQVYKLLNEMQLNPEKKIKKLSKGNRGRLKIVLALARRADVILLDEPFSGLDPMV RDSIVNSLVSYIDFEQQIVVIATHEIDEIETLLDEVIILANGEKVAQREVEDIREQEG MSVLQWFKSKMEVC*" /label="yhcG CDS" gene 931181..931879 /gene="yhcG" /locus_tag="BSU_09070" /old_locus_tag="BSU09070" /label="yhcG gene" CDS 931896..932813 /gene="yhcH" /locus_tag="BSU_09080" /old_locus_tag="BSU09080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7476193, 15870467; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_388789.1" /db_xref="EnsemblGenomes-Gn:BSU09080" /db_xref="EnsemblGenomes-Tr:CAB12736" /db_xref="GOA:P54592" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11586" /db_xref="UniProtKB/Swiss-Prot:P54592" /translation="MKTVLELKNVTKNIRGRTIIDDLSFTIREGEVFGFLGPNGAGKT TTIRMMVGLMKLSKGDVLICGQSITKEYAKAIKHIGAIVENPELYKFLSGYKNLQQFA RMVKGVTKEKIDEVVELVGLTDRIHDKVKTYSLGMRQRLGLAQCLLHDPKVLILDEPT NGLDPAGIREIRDHLKKLTRERGMAVIVSSHLLSEMELMCDRIAILQKGKLIDIQNVK DENIDENDTYFFQVEQPSEAATVLNQYDLLSKTNGVEIKLAKEEVPAVIELLVMQQIR IYEVKVITKSLEDRFLEMTGETKEEVQHA*" /label="yhcH CDS" gene 931896..932813 /gene="yhcH" /locus_tag="BSU_09080" /old_locus_tag="BSU09080" /label="yhcH gene" CDS 932806..933747 /gene="yhcI" /locus_tag="BSU_09090" /old_locus_tag="BSU09090" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 15870467, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (permease)" /protein_id="NP_388790.1" /db_xref="EnsemblGenomes-Gn:BSU09090" /db_xref="EnsemblGenomes-Tr:CAB12737" /db_xref="GOA:P54593" /db_xref="InterPro:IPR032688" /db_xref="SubtiList:BG11587" /db_xref="UniProtKB/Swiss-Prot:P54593" /translation="MLNLIYNEWLKIFSRAGTWVMIGILGLTMVGFAFLANHFSAGES NSHWKQELQAQNAELKKEIKEDPSLKDGYKETITLNDYRIEHNIPSDTGYTVWSYVTD SANFTILTGLFTIIIAAGIVANEFNWGTIKLLMIRPLSRFQILMSKYITVLLFGLLLL LILFIGSTLLGLIFFGTGGETAANIHLIYKDGHVIEQNMMGHLATTYLSESVSALMVA TMAFMLSAVFRNSSLAVGFSIFLLVAGTTATAFIAAKFDWAKYILFANVDLTQYVDGT PLIKGMTMTFSLVMLAIYFIIFLLLAFGIFMKRDIAN*" /label="yhcI CDS" gene 932806..933747 /gene="yhcI" /locus_tag="BSU_09090" /old_locus_tag="BSU09090" /label="yhcI gene" downshifts 933729 /Source="Nicolas_upshifts" /id="D468" /incds=0 /nref=43 /ntot=186 /MaxReadThrough="2.67567" /MaxDrop="4.46232" /score="20.0218504" /energy="-13.6" /TU="NA" /idTUdmin="U707" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(933839..934042) /gene="cspB" /locus_tag="BSU_09100" /old_locus_tag="BSU09100" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12493834, 16352840, 22128343, 25851716" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12493834, 16352840, 22128343, 25851716; Product type f: factor" /codon_start=1 /transl_table=11 /product="major cold-shock protein, RNA helicase co-factor, RNA co-chaperone" /protein_id="NP_388791.1" /db_xref="EnsemblGenomes-Gn:BSU09100" /db_xref="EnsemblGenomes-Tr:CAB12738" /db_xref="GOA:P32081" /db_xref="InterPro:IPR002059" /db_xref="InterPro:IPR011129" /db_xref="InterPro:IPR012156" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR019844" /db_xref="PDB:1CSP" /db_xref="PDB:1CSQ" /db_xref="PDB:1NMF" /db_xref="PDB:1NMG" /db_xref="PDB:2ES2" /db_xref="PDB:2F52" /db_xref="PDB:2I5L" /db_xref="PDB:2I5M" /db_xref="PDB:3PF4" /db_xref="PDB:3PF5" /db_xref="SubtiList:BG10824" /db_xref="UniProtKB/Swiss-Prot:P32081" /translation="MLEGKVKWFNSEKGFGFIEVEGQDDVFVHFSAIQGEGFKTLEEG QAVSFEIVEGNRGPQAANVTKEA*" /label="cspB CDS" gene complement(933839..934042) /gene="cspB" /locus_tag="BSU_09100" /old_locus_tag="BSU09100" /label="cspB gene" downshifts complement(933853) /Source="Nicolas_upshifts" /id="D469" /incds=0 /nref=169 /ntot=281 /MaxReadThrough="5.28215" /MaxDrop="9.14889" /score="33.2405587" /energy="-13.1" /TU="U710" /idTUdmin="U710" /TUdmin="-48" /isTUend="FALSE" /label="downshifts" S_feature complement(934043..934170) /Source="Nicolas_S_feature" /locus_tag="new_984466_984593_c" /HighExp="BC, C90, GM 15, BI, T-1.10H, UNK1, S1, Sw, nit, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.999" /label="S315" misc_feature 934130..934141 /Source="Nicolas_upshift_promotors" /id="U709" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.618381618381618" /psig="0.098901098901099" /xcortree=713 /SigmaFactorBS="ttgctcttaacaaactttcaagacgaaaactcttacaaaact tTCTTCTTAAAGAtagttcgaacaaaaataattacctttactctaccagtaatcttca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 934147 /Source="Nicolas_upshifts" /id="U709" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.618381618381618" /psig="0.098901098901099" /xcortree=713 /SigmaFactorBS="ttgctcttaacaaactttcaagacgaaaactcttacaaaact tTCTTCTTAAAGAtagttcgaacaaaaataattacctttactctaccagtaatcttca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(934159..934178) /Source="Nicolas_upshift_promotors" /id="U710" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.32967032967033" /psig=1 /xcortree=2182 /SigmaFactorBS="tatggtattttccgaaaaaaatttcaataagcaGTTGTTttt tctgaagattACTGGTAGAGTAAAGGTAATtatttttgttcgaactatctttaagaag a" /listShort="S315, cspB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(934170) /Source="Nicolas_upshifts" /id="U710" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.32967032967033" /psig=1 /xcortree=2182 /SigmaFactorBS="tatggtattttccgaaaaaaatttcaataagcaGTTGTTttt tctgaagattACTGGTAGAGTAAAGGTAATtatttttgttcgaactatctttaagaag a" /listShort="S315, cspB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(934172..935310) /Source="Nicolas_S_feature" /locus_tag="new_984595_985733_c" /HighExp="C30, G180, G150, Oxctl, G135, Paraq, HPh, LPh, dia0, Lbexp" /AntisenseName="yhcJ" /AntisenseCor="0.25433958616302499" /AntisenseRegPval="-4.5999999999999996" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S316" promotor_-35 complement(934192..934197) /Source="Nicolas_upshift_promotors" /id="U710" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.32967032967033" /psig=1 /xcortree=2182 /SigmaFactorBS="tatggtattttccgaaaaaaatttcaataagcaGTTGTTttt tctgaagattACTGGTAGAGTAAAGGTAATtatttttgttcgaactatctttaagaag a" /listShort="S315, cspB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 934337..934344 /Source="Nicolas_upshift_promotors" /id="U711" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.386613386613387" /psig="0.997002997002997" /xcortree=1871 /SigmaFactorBS="attccttcattttgggaagataagtaataggAATTGACAacc ttattggatatGAGTAAGGTAAAAGTTAATcaatattacaaatgacaacgtttatcaa c" /listShort="S317, yhcJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 934359..934377 /Source="Nicolas_upshift_promotors" /id="U711" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.386613386613387" /psig="0.997002997002997" /xcortree=1871 /SigmaFactorBS="attccttcattttgggaagataagtaataggAATTGACAacc ttattggatatGAGTAAGGTAAAAGTTAATcaatattacaaatgacaacgtttatcaa c" /listShort="S317, yhcJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 934366 /Source="Nicolas_upshifts" /id="U711" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.386613386613387" /psig="0.997002997002997" /xcortree=1871 /SigmaFactorBS="attccttcattttgggaagataagtaataggAATTGACAacc ttattggatatGAGTAAGGTAAAAGTTAATcaatattacaaatgacaacgtttatcaa c" /listShort="S317, yhcJ" /GFF_Attribute="listLong" /label="upshifts" S_feature 934367..934477 /Source="Nicolas_S_feature" /locus_tag="new_984790_984900" /HighExp="Diami, dia15, dia5, H2O2, Salt, C90, Paraq, UNK1, T-4.40H, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S317" CDS 934478..935308 /gene="yhcJ" /locus_tag="BSU_09110" /old_locus_tag="BSU09110" /function="7: Transport and binding proteins" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative ABC transporter (binding lipoprotein)" /protein_id="NP_388792.2" /db_xref="EnsemblGenomes-Gn:BSU09110" /db_xref="EnsemblGenomes-Tr:CAB12739" /db_xref="GOA:P54594" /db_xref="InterPro:IPR004872" /db_xref="SubtiList:BG11588" /db_xref="UniProtKB/Swiss-Prot:P54594" /translation="MKKWLICSFVLVLLVSFTACSPSAEHESIKIGIAESDGAIWNYI AQKAEEAGLDIQLIPFSDYAESDIALANKEIDANAFQTISYFQSFTEKYKLNLAPLGT TYITPMGIYSKRYERIRDISRGAVVSVPDKAFDFGRALTVLQEAGLLTLKNGFNGTGS VDMIKDNPRHLKLKAVRQQDAVSGADVFVMKPSEAKKAGLNPKKHTLKSGGLMSEEEM NLIVVRAEDQDREALQTILELYQADDTAAFIEKEYQGDLVPAFLPLKRLSDWKNEFEH *" /label="yhcJ CDS" gene 934478..935308 /gene="yhcJ" /locus_tag="BSU_09110" /old_locus_tag="BSU09110" /label="yhcJ gene" downshifts 935267 /Source="Nicolas_upshifts" /id="D470" /incds=0 /nref=38 /ntot=203 /MaxReadThrough="2.83059" /MaxDrop="3.90173" /score="-4.94928928" /energy="-7.3" /TU="NA" /idTUdmin="U711" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS complement(935311..936390) /gene="dgcK" /locus_tag="BSU_09120" /old_locus_tag="BSU09120" /EC_number="2.7.7.65" /function="16.3: Control" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:23893111" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23893111; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="diguanylate cyclase" /protein_id="NP_388793.1" /db_xref="EnsemblGenomes-Gn:BSU09120" /db_xref="EnsemblGenomes-Tr:CAB12740" /db_xref="GOA:P54595" /db_xref="InterPro:IPR000160" /db_xref="InterPro:IPR011620" /db_xref="InterPro:IPR029787" /db_xref="SubtiList:BG11589" /db_xref="UniProtKB/Swiss-Prot:P54595" /translation="MLKELFVNLTILITFNYLFTHLFKERLVHKKDSISFQAVKGLAC GLLGVILMVFGFTYQHSIIDLRNIPIMIAALYGGWVSTATALAMITAGRLLITMNTSA LYSVIIICIAAIPSLIVSRRKKVQLKHAFYLLIITNSLISFSFYFLIDLHSYELHLYF WIISIAGGMLSLYIIDHETNAHLLFKQYKFQAHFDFLTGVYNRRKFEETTKALYQQAA DTPHFQFALIYMDIDHFKTINDQYGHHEGDQVLKELGLRLKQTIRNTDPAARIGGEEF AVLLPNCSLDKAARIAERIRSTVSDAPIVLTNGDELSVTISLGAAHYPNNTEQPGSLP ILADQMLYKAKETGRNRVCFSEKKE*" /label="dgcK CDS" gene complement(935311..936390) /gene="dgcK" /locus_tag="BSU_09120" /old_locus_tag="BSU09120" /label="dgcK gene" promotor_-10 complement(936400..936419) /Source="Nicolas_upshift_promotors" /id="U712" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.988011988011988" /psig="0.999000999001" /xcortree=2608 /SigmaFactorBS="tatcaattcaagtaaaaaaaccttatataatgccttttttgt TCTTTtctttcccttccatcTTTAGTACCTTATATAAGGGtgataatatttgctgaaa g" /listShort="yhcK, S316" /listLong="S315, cspB" /label="promotor_-10" upshifts complement(936421) /Source="Nicolas_upshifts" /id="U712" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.988011988011988" /psig="0.999000999001" /xcortree=2608 /SigmaFactorBS="tatcaattcaagtaaaaaaaccttatataatgccttttttgt TCTTTtctttcccttccatcTTTAGTACCTTATATAAGGGtgataatatttgctgaaa g" /listShort="yhcK, S316" /listLong="S315, cspB" /label="upshifts" promotor_-35 complement(936435..936439) /Source="Nicolas_upshift_promotors" /id="U712" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.988011988011988" /psig="0.999000999001" /xcortree=2608 /SigmaFactorBS="tatcaattcaagtaaaaaaaccttatataatgccttttttgt TCTTTtctttcccttccatcTTTAGTACCTTATATAAGGGtgataatatttgctgaaa g" /listShort="yhcK, S316" /listLong="S315, cspB" /label="promotor_-35" promotor_-35 936497..936504 /Source="Nicolas_upshift_promotors" /id="U713" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.651348651348651" /psig=1 /xcortree=1745 /SigmaFactorBS="tttttacttgaattgataagttaaaataattcgCACTTGACc catcggaattagTGTAATATAGTAAATGAGAAaatttgaagggagagtttacctgctt t" /listShort="tcyP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 936518..936537 /Source="Nicolas_upshift_promotors" /id="U713" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.651348651348651" /psig=1 /xcortree=1745 /SigmaFactorBS="tttttacttgaattgataagttaaaataattcgCACTTGACc catcggaattagTGTAATATAGTAAATGAGAAaatttgaagggagagtttacctgctt t" /listShort="tcyP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 936524 /Source="Nicolas_upshifts" /id="U713" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.651348651348651" /psig=1 /xcortree=1745 /SigmaFactorBS="tttttacttgaattgataagttaaaataattcgCACTTGACc catcggaattagTGTAATATAGTAAATGAGAAaatttgaagggagagtttacctgctt t" /listShort="tcyP" /GFF_Attribute="listLong" /label="upshifts" CDS 936563..937954 /gene="tcyP" /locus_tag="BSU_09130" /old_locus_tag="BSU09130" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12193636, 15262924, 15849754, 16513748, 16850406, 19508281" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12193636, 15262924, 15849754, 16513748, 16850406, 19508281; Product type t : transporter" /codon_start=1 /transl_table=11 /product="(sodium)-cystine symporter" /protein_id="NP_388794.1" /db_xref="EnsemblGenomes-Gn:BSU09130" /db_xref="EnsemblGenomes-Tr:CAB12741" /db_xref="GOA:P54596" /db_xref="InterPro:IPR001991" /db_xref="InterPro:IPR036458" /db_xref="SubtiList:BG11590" /db_xref="UniProtKB/Swiss-Prot:P54596" /translation="METLLVVLHVFILFLLILGLFVMQKKHVSFSKRVFTALGLGIVF GFALQLIYGPTSNIVIQTADWFNIAGGGYVKLLQMVVMPLVFISILGAFTKLKLTKNL GKISGLIIGILVATTAVAAAVGIASALSFDLQAIQVDQGSTELSRGQELQQKSEDMTA KTLPQQIVELLPGNPFLDFTGARPTSTIAVVIFAAFLGVAFLGVKHKQPEQAETFKKL VDAVYAIVMRVVTLILRLTPYGVLAIMTKTIATSDLDSILKLGMFVIASYAALITMFI IHLLLLTFSGLNPVIYLKKAVPVLVFAFTSRSSAGALPLNIKTQRSMGVPEGIANFAG SFGLSIGQNGCAGIYPAMLAMMIAPTVGQNPFDPVFIITVIAVVAISSFGVAGVGGGA TFAALLVLSSLNMPVALAGLLISIEPLIDMGRTALNVSGSMTSGLITSKVTKEIDQGA FHDQSRVIEAEEA*" /label="tcyP CDS" gene 936563..937954 /gene="tcyP" /locus_tag="BSU_09130" /old_locus_tag="BSU09130" /label="tcyP gene" S_feature complement(937590..937993) /Source="Nicolas_S_feature" /locus_tag="new_988013_988416_c" /HighExp="S8, S6, Etha, S5, S7, S4, ferm, nit, Salt, S3" /AntisenseName="tcyP" /AntisenseCor="-0.40132140065468203" /AntisenseRegPval="-11.1" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.96" /TUlongSig="NA" /TUlongPSig="NA" /label="S318" downshifts 937933 /Source="Nicolas_upshifts" /id="D471" /incds=0 /nref=58 /ntot=164 /MaxReadThrough="2.37899" /MaxDrop="5.34563" /score="19.9118074" /energy="-12.8" /TU="NA" /idTUdmin="U713" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" CDS complement(937994..938449) /gene="yhcM" /locus_tag="BSU_09140" /old_locus_tag="BSU09140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 21625606" /codon_start=1 /transl_table=11 /product="expressed protein of unknown function" /protein_id="NP_388795.1" /db_xref="EnsemblGenomes-Gn:BSU09140" /db_xref="EnsemblGenomes-Tr:CAB12742" /db_xref="SubtiList:BG11591" /db_xref="UniProtKB/Swiss-Prot:P54597" /translation="MLFNQRRGISPAALIIGSTMLITALSPQIRQRISGFITGQMNRR NSENNTFDASNVGNMVKQAFSGSSGSSGDNQDRSQHQSQRQNGRQHQHAGQQQPQHQH TQSQTRQTETAAKKRQPHYAEPIHFEQNAMNVMDDNTMMEMLEDLEPGR*" /label="yhcM CDS" gene complement(937994..938449) /gene="yhcM" /locus_tag="BSU_09140" /old_locus_tag="BSU09140" /label="yhcM gene" promotor_-10 complement(938464..938482) /Source="Nicolas_upshift_promotors" /id="U714" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=733 /SigmaFactorBS="tttaattatgcatgcaaatctggaggaaatgctttcccggga aatataaCGGTTAAtttgtctaacgaggGGGAAAATATGAATACACTgcaaaggaggg a" /listShort="yhcM, S318" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(938492) /Source="Nicolas_upshifts" /id="U714" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=733 /SigmaFactorBS="tttaattatgcatgcaaatctggaggaaatgctttcccggga aatataaCGGTTAAtttgtctaacgaggGGGAAAATATGAATACACTgcaaaggaggg a" /listShort="yhcM, S318" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(938497..938503) /Source="Nicolas_upshift_promotors" /id="U714" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=733 /SigmaFactorBS="tttaattatgcatgcaaatctggaggaaatgctttcccggga aatataaCGGTTAAtttgtctaacgaggGGGAAAATATGAATACACTgcaaaggaggg a" /listShort="yhcM, S318" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 938541..938547 /Source="Nicolas_upshift_promotors" /id="U715" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=835 /SigmaFactorBS="tatatttcccgggaaagcatttcctccagatttgcaTGCATA AttaaagccagttaGAAAAACCTATAagtaaagtgataaaggaggaattcacatgttt g" /listShort="yhcN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 938561..938572 /Source="Nicolas_upshift_promotors" /id="U715" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=835 /SigmaFactorBS="tatatttcccgggaaagcatttcctccagatttgcaTGCATA AttaaagccagttaGAAAAACCTATAagtaaagtgataaaggaggaattcacatgttt g" /listShort="yhcN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 938565 /Source="Nicolas_upshifts" /id="U715" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=835 /SigmaFactorBS="tatatttcccgggaaagcatttcctccagatttgcaTGCATA AttaaagccagttaGAAAAACCTATAagtaaagtgataaaggaggaattcacatgttt g" /listShort="yhcN" /GFF_Attribute="listLong" /label="upshifts" CDS 938599..939168 /gene="yhcN" /locus_tag="BSU_09150" /old_locus_tag="BSU09150" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9611260, 28333204; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative germination lipoprotein" /protein_id="NP_388796.2" /db_xref="EnsemblGenomes-Gn:BSU09150" /db_xref="EnsemblGenomes-Tr:CAB12743" /db_xref="GOA:P54598" /db_xref="InterPro:IPR014247" /db_xref="InterPro:IPR019076" /db_xref="SubtiList:BG11592" /db_xref="UniProtKB/Swiss-Prot:P54598" /translation="MFGKKQVLASVLLIPLLMTGCGVADQGEGRRDNNDVRNVNYRNP ANDDMRNVNNRDNVDNNVNDNVNNNRVNDDNNNDRKLEVADEAADKVTDLKEVKHADI IVAGNQAYVAVVLTNGNKGAVENNLKKKIAKKVRSTDKNIDNVYVSANPDFVERMQGY GKRIQNGDPIAGLFDEFTQTVQRVFPNAE*" /label="yhcN CDS" gene 938599..939168 /gene="yhcN" /locus_tag="BSU_09150" /old_locus_tag="BSU09150" /label="yhcN gene" promotor_-35 938795..938801 /Source="Nicolas_upshift_promotors" /id="U716" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.634365634365634" /psig="0.634365634365634" /xcortree=783 /SigmaFactorBS="gtaaacaatcgggataacgttgacaacaatgttaatgataat gTCAATAAcaatcgtgtaaatGACGATAATAACaacgaccgaaaacttgaggttgctg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 938812 /Source="Nicolas_upshifts" /id="U716" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.634365634365634" /psig="0.634365634365634" /xcortree=783 /SigmaFactorBS="gtaaacaatcgggataacgttgacaacaatgttaatgataat gTCAATAAcaatcgtgtaaatGACGATAATAACaacgaccgaaaacttgaggttgctg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 938815..938826 /Source="Nicolas_upshift_promotors" /id="U716" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.634365634365634" /psig="0.634365634365634" /xcortree=783 /SigmaFactorBS="gtaaacaatcgggataacgttgacaacaatgttaatgataat gTCAATAAcaatcgtgtaaatGACGATAATAACaacgaccgaaaacttgaggttgctg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 939143 /Source="Nicolas_upshifts" /id="D472" /incds=0 /nref=26 /ntot=183 /MaxReadThrough="1.84697" /MaxDrop="7.80159" /score="33.0647397" /energy="-12.9" /TU="NA" /idTUdmin="U715" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" promotor_-35 939211..939220 /Source="Nicolas_upshift_promotors" /id="U717" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1355 /SigmaFactorBS="caatttgtgcggctttttctttgcgttAATGACACACtgcga actcaggcTGCATAGAGTAAAAATAAAAaggtacaagacggaccggctcagggaggga g" /listShort="yhcO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 939234..939253 /Source="Nicolas_upshift_promotors" /id="U717" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1355 /SigmaFactorBS="caatttgtgcggctttttctttgcgttAATGACACACtgcga actcaggcTGCATAGAGTAAAAATAAAAaggtacaagacggaccggctcagggaggga g" /listShort="yhcO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 939244 /Source="Nicolas_upshifts" /id="U717" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1355 /SigmaFactorBS="caatttgtgcggctttttctttgcgttAATGACACACtgcga actcaggcTGCATAGAGTAAAAATAAAAaggtacaagacggaccggctcagggaggga g" /listShort="yhcO" /GFF_Attribute="listLong" /label="upshifts" CDS 939289..940257 /gene="yhcO" /locus_tag="BSU_09165" /old_locus_tag="BSU09165" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="putative exported protein (sporulation germination island)" /protein_id="NP_388797.2" /db_xref="EnsemblGenomes-Gn:BSU09165" /db_xref="EnsemblGenomes-Tr:CAB12744" /db_xref="SubtiList:BG11593" /db_xref="UniProtKB/Swiss-Prot:P54599" /translation="MRDGIGKRAASALFLCGVLVMLAVSSAIVSSAMYILSFPGQASG ITKEQVTKHMKKESFKQADIYYTSKEKSLLPLTKETLEYAVSINQIMIGYSNQKPIDI IFFPNEKQMEAYSGLLDVVGFYSEREQLIGLLPEEKKKLLEGDEVAVYLYQRLLIHEY SHHAFHQKLKELETDPDEFPLWFHEGLSEWIANYELLIDPITFSVVPFDRLQTDRDWQ EARAEYDTDVYLQSFYMIDELTDKYGKDIISEMIKETAKKGDFEKGFKSATKESLDQF EKDFKKKFEKNSAALDSIYPMPLLLVKSLLTHSALCRRHLSLGRGE*" /label="yhcO CDS" gene 939289..940257 /gene="yhcO" /locus_tag="BSU_09165" /old_locus_tag="BSU09165" /label="yhcO gene" downshifts 940133 /Source="Nicolas_upshifts" /id="D473" /incds=1 /nref=28 /ntot=62 /MaxReadThrough="1.51621" /MaxDrop="5.75619" /score="6.21571271" /energy="-16.1" /TU="NA" /idTUdmin="U717" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(940189..940842) /gene="yhcQ" /locus_tag="BSU_09180" /old_locus_tag="BSU09180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_388799.1" /db_xref="EnsemblGenomes-Gn:BSU09180" /db_xref="EnsemblGenomes-Tr:CAB12746" /db_xref="GOA:P54601" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR012851" /db_xref="SubtiList:BG11595" /db_xref="UniProtKB/Swiss-Prot:P54601" /translation="MDQFNQQQQSQMNKGIPGKPHKNHGGHEMFDMHEVLSGTLTVLD QFMMLRQFCKDQELLNILDRQHQFITSQYNITAECFKTGSEPSQKTATYMMKEDNQTV YGMQPSQPKKPVQSMNDIDDSIISRQMLCAIKAQASMLTMASLEMTNPAVRRVLSAQI QEYVEMAFEIFLYQNKHGYYQVPQLDAQDMEQLRNSFAPAQGQMPPTQGGMGQQGLH* " /label="yhcQ CDS" gene complement(940189..940842) /gene="yhcQ" /locus_tag="BSU_09180" /old_locus_tag="BSU09180" /label="yhcQ gene" downshifts complement(940206) /Source="Nicolas_upshifts" /id="D474" /incds=0 /nref=15 /ntot=57 /MaxReadThrough="4.13099" /MaxDrop="4.95733" /score="8.67086892" /energy="-12.9" /TU="U718" /idTUdmin="U718" /TUdmin="-546" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(940873..940884) /Source="Nicolas_upshift_promotors" /id="U718" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=828 /SigmaFactorBS="acagacagcatataattcctttcaggcttcTGCATAAtacac ggcagactgACACAAAATACAgctgatctgaaaaaaaaggaggaattcggtttggatc a" /listShort="yhcQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(940875) /Source="Nicolas_upshifts" /id="U718" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=828 /SigmaFactorBS="acagacagcatataattcctttcaggcttcTGCATAAtacac ggcagactgACACAAAATACAgctgatctgaaaaaaaaggaggaattcggtttggatc a" /listShort="yhcQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(940899..940905) /Source="Nicolas_upshift_promotors" /id="U718" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=828 /SigmaFactorBS="acagacagcatataattcctttcaggcttcTGCATAAtacac ggcagactgACACAAAATACAgctgatctgaaaaaaaaggaggaattcggtttggatc a" /listShort="yhcQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 940914..940922 /Source="Nicolas_upshift_promotors" /id="U719" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=543 /SigmaFactorBS="tctgccgtgtattatgcagaagcctgAAAGGAATTatatgct gtcTGTCGAAATGATAAGCAGAcaaaatcgttgtcattatgtgtataagggaggaaat a" /listShort="yhcR, yhcS" /GFF_Attribute="listLong" /label="promotor_-35" CDS 940925..944578 /gene="mncR" /locus_tag="BSU_09190" /old_locus_tag="BSU09190" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15292138, 21800427, 22020651" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15292138, 21800427, 22020651; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="non specific extracellular Ca2+-dependent endonuclease cleaving RNA and DNA" /protein_id="NP_388800.1" /db_xref="EnsemblGenomes-Gn:BSU09190" /db_xref="EnsemblGenomes-Tr:CAB12747" /db_xref="GOA:P54602" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR006146" /db_xref="InterPro:IPR006179" /db_xref="InterPro:IPR008334" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR016071" /db_xref="InterPro:IPR019948" /db_xref="InterPro:IPR029052" /db_xref="InterPro:IPR035437" /db_xref="InterPro:IPR035451" /db_xref="InterPro:IPR036907" /db_xref="SubtiList:BG11596" /db_xref="UniProtKB/Swiss-Prot:P54602" /translation="MLSVEMISRQNRCHYVYKGGNMMRRILHIVLITALMFLNVMYTF EAVKAAEPQQPISIEKAIQQKEGQALVEGYAVGQAVSPQHYKLTSPFSNDYNVALADR KNKTSPEHILPVQIPSAFRSQFGLQTNPLLLGKKITVQGKLENYFNTTGLKNVQSMNV TDDTKTPPAEQQVTINEARGRLNEEVTIKGIITADQNAIGGGKLSTFLQDETGGINIY SPSPEQFPELKEGMDVTVTGKITSYQGLKEIVPNSSGIKINQSNQSLPAPKHLTINEL INGSLGDQYEGRLVKLTAFVSSIPSSPAGGGYNVTMIDDDHHAMTLRVMNETGVINEL DEGKWYEFTGVLSRYQTFQLLPRKSADLKLLEEQPAPPSAEGEYEGIVDRVVDGDTIH LKSPVLGTTKIRFVNVDAPETYHTPKNDADENQLRFGKKASDYLKTVLSPGDKITVKV GSEAKDSYGRLLGQVITESGSNVNLELVKNGYAPTYFIWPVDNEEDYQQFQAAVAAAK KDQKGIWNENDPLMEMPFEFRAREQGKGLTRYVGDSSNKTYVQPADWKKIAVENRIFF ASASEAESAGYKKRQTAPQEHVPLRILSMNDLHGKIDQQYELDLDGNGTVDGTFGRMD YAAAYLKEKKAEKKNSLIVHAGDMIGGSSPVSSLLQDEPTVELMEDIGFDVGTVGNHE FDEGTDELLRILNGGDHPKGTSGYDGQNFPLVCANCKMKSTGEPFLPAYDIINVEGVP VAFIGVVTQSAAGMVMPEGIKNIEFTDEATAVNKAAEELKKKGVKAIAVLAHMSAEQN GNAITGESADLANKTDSEIDVIFAAHNHQVVNGEVNGKLIVQAFEYGKAIGVVDVEID KTTKDIVKKSAEIVYVDQSKIEPDVSASAILKKYETIAEPIISEVVGEAAVDMEGGYS NDGDTPLGNLIADGMRAAMKTDFALMNGGGIREALKKGPITWGDLYNIQPFGNVLTKL EIKGKDLREIINAQISPVFGPDYSISGFTYTWDKETGKAVDMKMADGTEIQPDATYTL TVNNFMATATGAKYQPIGLLGKNPVTGPEDLEATVEYVKSFDEPIAYTKEGRIKLAEA SDIEDPVTEDPITEEPGDDPGTEDPIKEDPRPGEDLPDIKETPGTAPVHQLPPSAISR FNEIPINNTKTADTANSISTLPLQTETAESGSDHQLPDTSAGYYNFMVIGAAVTLSGT YLYVRRKRSASRT*" /label="mncR CDS" gene 940925..944578 /gene="mncR" /locus_tag="BSU_09190" /old_locus_tag="BSU09190" /label="mncR gene" promotor_-10 940933..940951 /Source="Nicolas_upshift_promotors" /id="U719" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=543 /SigmaFactorBS="tctgccgtgtattatgcagaagcctgAAAGGAATTatatgct gtcTGTCGAAATGATAAGCAGAcaaaatcgttgtcattatgtgtataagggaggaaat a" /listShort="yhcR, yhcS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 940948 /Source="Nicolas_upshifts" /id="U719" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=543 /SigmaFactorBS="tctgccgtgtattatgcagaagcctgAAAGGAATTatatgct gtcTGTCGAAATGATAAGCAGAcaaaatcgttgtcattatgtgtataagggaggaaat a" /listShort="yhcR, yhcS" /GFF_Attribute="listLong" /label="upshifts" CDS 944575..945171 /gene="srtA" /locus_tag="BSU_09200" /old_locus_tag="BSU09200" /EC_number="3.4.22.70" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12823805, 21800427, 22020651, 25038633" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12823805, 21800427, 22020651, 25038633; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sortase A" /protein_id="NP_388801.1" /db_xref="EnsemblGenomes-Gn:BSU09200" /db_xref="EnsemblGenomes-Tr:CAB12748" /db_xref="GOA:P54603" /db_xref="InterPro:IPR005754" /db_xref="InterPro:IPR023365" /db_xref="SubtiList:BG11597" /db_xref="UniProtKB/Swiss-Prot:P54603" /translation="MKKVIPLFIIAAGLVIAGYGGFKLIDTNTKTEQTLKEAKLAAKK PQEASGTKNSTDQAKNKASFKPETGQASGILEIPKINAELPIVEGTDADDLEKGVGHY KDSYYPDENGQIVLSGHRDTVFRRTGELEKGDQLRLLLSYGEFTYEIVKTKIVDKDDT SIITLQHEKEELILTTCYPFSYVGNAPKRYIIYGKRVT*" /label="srtA CDS" gene 944575..945171 /gene="srtA" /locus_tag="BSU_09200" /old_locus_tag="BSU09200" /label="srtA gene" downshifts 945150 /Source="Nicolas_upshifts" /id="D475" /incds=0 /nref=142 /ntot=248 /MaxReadThrough="0.9984" /MaxDrop="5.92245" /score="-4.06268332" /energy="-8.8" /TU="NA" /idTUdmin="U719" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(945201..946109) /gene="yhcT" /locus_tag="BSU_09210" /old_locus_tag="BSU09210" /EC_number="5.4.99.-" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9814761, 15044829; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA pseudouridine synthase" /protein_id="NP_388802.2" /db_xref="EnsemblGenomes-Gn:BSU09210" /db_xref="EnsemblGenomes-Tr:CAB12749" /db_xref="GOA:P54604" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR006145" /db_xref="InterPro:IPR006224" /db_xref="InterPro:IPR006225" /db_xref="InterPro:IPR020103" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG11598" /db_xref="UniProtKB/Swiss-Prot:P54604" /translation="MNQKGRGLEILINEKQDGQWLFSVLKTALKASKPVIQDWMSHQQ IKVNHESVLNNMIVKKGDRVFIDLQESEASSVIPEYGELDILFEDNHMLIINKPAGIA THPNEDGQTGTLANLIAYHYQINGETCKVRHVHRLDQDTSGAIVFAKHRLAHAILDQQ LEKKTLKRTYTAIAEGKLRTKKGTINSPIGRDRSHPTRRRVSPGGQTAVTHFKVMASN AKERLSLVELELETGRTHQIRVHLASLGHPLTGDSLYGGGSKLLNRQALHANKVQAVH PITDELIVAEAPFPADMKNLCRTYFS*" /label="yhcT CDS" gene complement(945201..946109) /gene="yhcT" /locus_tag="BSU_09210" /old_locus_tag="BSU09210" /label="yhcT gene" promotor_-35 946165..946173 /Source="Nicolas_upshift_promotors" /id="U721" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig="0.999000999001" /xcortree=2026 /SigmaFactorBS="tttcgaagcggaaggctgctgtttctcataggaaacacttaC CTTAGCTTtcgcgtttttttcTGTGCTATTCTTGAGTAAGActtaggatattcgatgg c" /listShort="yhcU" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(946166..946177) /Source="Nicolas_upshift_promotors" /id="U720" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=803 /SigmaFactorBS="cctttcttgccatcgaatatcctaagtcttactcaAGAATAG cacagaaaaaaacGCGAAAGCTAAGgtaagtgtttcctatgagaaacagcagccttcc g" /listShort="yhcT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(946172) /Source="Nicolas_upshifts" /id="U720" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=803 /SigmaFactorBS="cctttcttgccatcgaatatcctaagtcttactcaAGAATAG cacagaaaaaaacGCGAAAGCTAAGgtaagtgtttcctatgagaaacagcagccttcc g" /listShort="yhcT" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(946174..946660) /Source="Nicolas_S_feature" /locus_tag="new_996597_997083_c" /HighExp="S8, dia15, Diami, H2O2, G180, G150, dia5, Paraq, Oxctl, S7" /AntisenseName="yhcU" /AntisenseCor="0.69394173601478304" /AntisenseRegPval="-39.200000000000003" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.958" /TUlongSig="NA" /TUlongPSig="NA" /label="S319" upshifts 946184 /Source="Nicolas_upshifts" /id="U721" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig="0.999000999001" /xcortree=2026 /SigmaFactorBS="tttcgaagcggaaggctgctgtttctcataggaaacacttaC CTTAGCTTtcgcgtttttttcTGTGCTATTCTTGAGTAAGActtaggatattcgatgg c" /listShort="yhcU" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 946187..946206 /Source="Nicolas_upshift_promotors" /id="U721" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig="0.999000999001" /xcortree=2026 /SigmaFactorBS="tttcgaagcggaaggctgctgtttctcataggaaacacttaC CTTAGCTTtcgcgtttttttcTGTGCTATTCTTGAGTAAGActtaggatattcgatgg c" /listShort="yhcU" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(946191..946197) /Source="Nicolas_upshift_promotors" /id="U720" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=803 /SigmaFactorBS="cctttcttgccatcgaatatcctaagtcttactcaAGAATAG cacagaaaaaaacGCGAAAGCTAAGgtaagtgtttcctatgagaaacagcagccttcc g" /listShort="yhcT" /GFF_Attribute="listLong" /label="promotor_-35" CDS 946220..946615 /gene="yhcU" /locus_tag="BSU_09220" /old_locus_tag="BSU09220" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388803.2" /db_xref="EnsemblGenomes-Gn:BSU09220" /db_xref="EnsemblGenomes-Tr:CAB12750" /db_xref="InterPro:IPR020355" /db_xref="SubtiList:BG11599" /db_xref="UniProtKB/Swiss-Prot:P54605" /translation="MARKVIDVRIVNAATAEQESFIKELSMELIHDVFPLYFSELDIQ RFKKKGVLSLNNHYYQGTLKEAFQIMACLQMIHIILTKPSPHSDLSDQAIFEKNSKML NDFGIYFPFAFSDFQKKTNKAFFGQRRLI*" /label="yhcU CDS" gene 946220..946615 /gene="yhcU" /locus_tag="BSU_09220" /old_locus_tag="BSU09220" /label="yhcU gene" misc_feature complement(946646..946665) /Source="Nicolas_upshift_promotors" /id="U722" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.709290709290709" /psig="0.958041958041958" /xcortree=1819 /SigmaFactorBS="cagacacgagccgtttaaaaagggagttagaggaaaggtttt atgatatgatttcTCTGATACAAAAAGAGCTTTtctaaaaatagaaaagcccttgccg c" /listShort="S319, yhcT" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(946660) /Source="Nicolas_upshifts" /id="U722" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.709290709290709" /psig="0.958041958041958" /xcortree=1819 /SigmaFactorBS="cagacacgagccgtttaaaaagggagttagaggaaaggtttt atgatatgatttcTCTGATACAAAAAGAGCTTTtctaaaaatagaaaagcccttgccg c" /listShort="S319, yhcT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 946700..946706 /Source="Nicolas_upshift_promotors" /id="U723" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=842 /SigmaFactorBS="tttgtatcagagaaatcatatcataaaacctttcctctaact cccTTTTTAAacggctcgtgtctGAACATACTAATgattgaaaggggtgctgacaatg a" /listShort="yhcV" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 946715 /Source="Nicolas_upshifts" /id="U723" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=842 /SigmaFactorBS="tttgtatcagagaaatcatatcataaaacctttcctctaact cccTTTTTAAacggctcgtgtctGAACATACTAATgattgaaaggggtgctgacaatg a" /listShort="yhcV" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 946720..946731 /Source="Nicolas_upshift_promotors" /id="U723" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=842 /SigmaFactorBS="tttgtatcagagaaatcatatcataaaacctttcctctaact cccTTTTTAAacggctcgtgtctGAACATACTAATgattgaaaggggtgctgacaatg a" /listShort="yhcV" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(946730..946744) /Source="Nicolas_upshift_promotors" /id="U724" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.99000999000999" /psig="0.002997002997003" /xcortree=708 /SigmaFactorBS="ttcggagaaacggttgccacctgcgttgtcattgtatcttta actgaaCTCATtgtcagcACCCCTTTCAATCATtagtatgttcagacacgagccgttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(946744) /Source="Nicolas_upshifts" /id="U724" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.99000999000999" /psig="0.002997002997003" /xcortree=708 /SigmaFactorBS="ttcggagaaacggttgccacctgcgttgtcattgtatcttta actgaaCTCATtgtcagcACCCCTTTCAATCATtagtatgttcagacacgagccgttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(946752..946756) /Source="Nicolas_upshift_promotors" /id="U724" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.99000999000999" /psig="0.002997002997003" /xcortree=708 /SigmaFactorBS="ttcggagaaacggttgccacctgcgttgtcattgtatcttta actgaaCTCATtgtcagcACCCCTTTCAATCATtagtatgttcagacacgagccgttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 946752..947174 /gene="yhcV" /locus_tag="BSU_09230" /old_locus_tag="BSU09230" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17322312; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative CBS containing enzyme (sporulation-/ germination-related)" /protein_id="NP_388804.1" /db_xref="EnsemblGenomes-Gn:BSU09230" /db_xref="EnsemblGenomes-Tr:CAB12751" /db_xref="InterPro:IPR000644" /db_xref="SubtiList:BG11600" /db_xref="UniProtKB/Swiss-Prot:P54606" /translation="MSSVKDTMTTQVATVSPNQTIQEAASLMKQHNVGAIPVVEQGVL KGMLTDRDIALRTTAQGRDGQTPVSEVMSTELVSGNPNMSLEDASQLMAQHQIRRLPI VDQNNLVGIVALGDLAVNQMSNESAGSALTNISHQNIH*" /label="yhcV CDS" gene 946752..947174 /gene="yhcV" /locus_tag="BSU_09230" /old_locus_tag="BSU09230" /label="yhcV gene" promotor_no_box complement(947078..947178) /Source="Nicolas_upshift_promotors" /id="U725" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.3996003996004" /psig="0.014985014985015" /xcortree=1493 /SigmaFactorBS="cttattaatgaatgttttggtgagaaatgtttgtcagcgctg atcccgcagactcgttcgacatctgattgactgccaggtctccaagcgcaacgatccc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(947118) /Source="Nicolas_upshifts" /id="U725" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.3996003996004" /psig="0.014985014985015" /xcortree=1493 /SigmaFactorBS="cttattaatgaatgttttggtgagaaatgtttgtcagcgctg atcccgcagactcgttcgacatctgattgactgccaggtctccaagcgcaacgatccc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 947152 /Source="Nicolas_upshifts" /id="D476" /incds=0 /nref=50 /ntot=61 /MaxReadThrough="2.62549" /MaxDrop="7.03747" /score="-2.59023198" /energy="-12.1" /TU="NA" /idTUdmin="U723" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(947184) /Source="Nicolas_upshifts" /id="D477" /incds=0 /nref=2 /ntot=10 /MaxReadThrough="0.0992700000000006" /MaxDrop="3.96142" /score="-9.32793172" /energy="-9.1" /TU="NA" /idTUdmin="U724" /TUdmin="-506" /isTUend="FALSE" /label="downshifts" promotor_-35 947224..947231 /Source="Nicolas_upshift_promotors" /id="U726" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=1997 /SigmaFactorBS="gtgcaggctctttcttcacataaaaccttacTTTTTGAAagc agacttgtttCGGGGTATAGTGAGTGTATAcatatgtctcaattcgtactaaaggagt t" /listShort="yhcW, yhcX, yhzG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 947245..947264 /Source="Nicolas_upshift_promotors" /id="U726" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=1997 /SigmaFactorBS="gtgcaggctctttcttcacataaaaccttacTTTTTGAAagc agacttgtttCGGGGTATAGTGAGTGTATAcatatgtctcaattcgtactaaaggagt t" /listShort="yhcW, yhcX, yhzG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 947253 /Source="Nicolas_upshifts" /id="U726" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=1997 /SigmaFactorBS="gtgcaggctctttcttcacataaaaccttacTTTTTGAAagc agacttgtttCGGGGTATAGTGAGTGTATAcatatgtctcaattcgtactaaaggagt t" /listShort="yhcW, yhcX, yhzG" /GFF_Attribute="listLong" /label="upshifts" CDS 947301..947963 /gene="glpW" /locus_tag="BSU_09240" /old_locus_tag="BSU09240" /EC_number="3.1.3.18" /EC_number="3.1.3.68" /EC_number="3.1.3.-" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16990279, 22353596; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous phosphoglycolate phosphatase / glycerol-3-phosphate phosphatase / 2-deoxyglucose-6-phosphatase" /protein_id="NP_388805.1" /db_xref="EnsemblGenomes-Gn:BSU09240" /db_xref="EnsemblGenomes-Tr:CAB12752" /db_xref="GOA:P54607" /db_xref="InterPro:IPR006439" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG11601" /db_xref="UniProtKB/Swiss-Prot:P54607" /translation="MIKALIFDFDGLILDTETHEYEVLQEIFEEHGSVLPLSVWGKVI GTAAGFRPFEYLEEQIGKKLNHEELTQLRRERFAKRMESEKARPGVEAYLNAAKDLGL KIGLASSSDYKWVSGHLKQIGLFDDFEVIQTADDVEEVKPNPELYLLAAKNLGVSPAE CLAFEDSVNGSIAAKRAGMKCVIVPNKVTGTLMFEDYDHRLESMAEMELALLLDHLNS QN*" /label="glpW CDS" gene 947301..947963 /gene="glpW" /locus_tag="BSU_09240" /old_locus_tag="BSU09240" /label="glpW gene" CDS 947979..949520 /gene="yhcX" /locus_tag="BSU_09250" /old_locus_tag="BSU09250" /EC_number="3.5.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26337367, 26808445, 17555270; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative amidohydrolase" /protein_id="NP_388806.2" /db_xref="EnsemblGenomes-Gn:BSU09250" /db_xref="EnsemblGenomes-Tr:CAB12753" /db_xref="GOA:P54608" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR001110" /db_xref="InterPro:IPR003010" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR036526" /db_xref="SubtiList:BG11602" /db_xref="UniProtKB/Swiss-Prot:P54608" /translation="MSEKLDLTRFEKKMVIRNIEEKDIDKIIDLQKDCFPGMEPWKRE HLISHLEHFPEGQFCAEFEGEIIGSCSSLLINFDEYDDRHTWQDITDDGYITNHNPDG LNMYGIEVMVHPKYRRMKIGHRLYEARKDLARRLNLKSIIIGGRIPNYHKYAEEMTAR EYVEQVTRHQIYDPVLSFQLMNGFTLMRINPNYLPDDTASIKYATLMEWNNVDYLPQQ TKRYYKSAFPVRICVIQYEMKKIYSFEEFANQVEYYVDVASDARSDFAVFPEIFTTQL MSFLEERSPSLAVQRITEYTEDYISLFTDLAVKYNVNIIGGSHFVEEEGKIYNIAYLF RRDGTIEKQYKLHITPNERKWWGISAGDQVRVFDTDCGKIAIQICYDIEFPELARIAA DKGAKIIFTPFCTEDRQGYLRVRYCSQARAVENQIYTVISGTVGNLPQTENMDIQYAQ SGIFAPSDFEFARDGIVGETNPNIEMVVIGDVDLEILRRQRQNGTVRQLKDRRRDIYH IQYKK*" /label="yhcX CDS" gene 947979..949520 /gene="yhcX" /locus_tag="BSU_09250" /old_locus_tag="BSU09250" /label="yhcX gene" downshifts 949503 /Source="Nicolas_upshifts" /id="D478" /incds=0 /nref=57 /ntot=238 /MaxReadThrough="4.24486" /MaxDrop="5.06754" /score="24.7413026" /energy="-10.5" /TU="U726" /idTUdmin="U726" /TUdmin="-224" /isTUend="FALSE" /label="downshifts" CDS 949604..949795 /gene="yhzG" /locus_tag="BSU_09259" /old_locus_tag="BSU09259" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:CAX52585.1" /translation="MYSGCALWSFCIFAISYIIQKTARLHIAIAMAVQVVSSATFIST MLSIVTLPVLLWKLHPLSS*" /label="yhzG CDS" gene 949604..949795 /gene="yhzG" /locus_tag="BSU_09259" /old_locus_tag="BSU09259" /pseudo /label="yhzG gene" promotor_-35 949826..949833 /Source="Nicolas_upshift_promotors" /id="U727" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.923076923076923" /psig=1 /xcortree=333 /SigmaFactorBS="aggggatgttttattatttacgcggttTATTGACTctgaccc ggtctggCTTTATATTGAAGGCAGGGAaatcatcaccaagacatcacataaagagaag g" /listShort="S320, yhxA, glpP, S321, glpF, glpK" /listLong="S322, glpD, S323, pgcA" /label="promotor_-35" promotor_-10 949848..949867 /Source="Nicolas_upshift_promotors" /id="U727" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.923076923076923" /psig=1 /xcortree=333 /SigmaFactorBS="aggggatgttttattatttacgcggttTATTGACTctgaccc ggtctggCTTTATATTGAAGGCAGGGAaatcatcaccaagacatcacataaagagaag g" /listShort="S320, yhxA, glpP, S321, glpF, glpK" /listLong="S322, glpD, S323, pgcA" /label="promotor_-10" S_feature 949859..949940 /Source="Nicolas_S_feature" /locus_tag="new_1000282_1000363" /HighExp="M40t90, M0t90, T0.30H, LBGstat, BC, Lbstat, M9-stat, Lbtran, T1.0H, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S320" upshifts 949859 /Source="Nicolas_upshifts" /id="U727" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.923076923076923" /psig=1 /xcortree=333 /SigmaFactorBS="aggggatgttttattatttacgcggttTATTGACTctgaccc ggtctggCTTTATATTGAAGGCAGGGAaatcatcaccaagacatcacataaagagaag g" /listShort="S320, yhxA, glpP, S321, glpF, glpK" /listLong="S322, glpD, S323, pgcA" /label="upshifts" CDS 949941..951293 /gene="yhxA" /locus_tag="BSU_09260" /old_locus_tag="BSU09260" /EC_number="2.6.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11082195, 23610425; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aminotransferase" /protein_id="NP_388807.2" /db_xref="EnsemblGenomes-Gn:BSU09260" /db_xref="EnsemblGenomes-Tr:CAB12754" /db_xref="GOA:P33189" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG10184" /db_xref="UniProtKB/Swiss-Prot:P33189" /translation="MEMMGMENIQQNQGLKQKDEQFVWHAMKGAHQADSLIAQKAEGA WVTDTDGRRYLDAMSGLWCVNIGYGRKELAEAAYEQLKELPYYPLTQSHAPAIQLAEK LNEWLGGDYVIFFSNSGSEANETAFKIARQYHLQNGDHSRYKFISRYRAYHGNTLGAL SATGQAQRKYKYEPLSQGFLHAAPPDIYRNPDDADTLESANEIDRIMTWELSETIAGV IMEPIITGGGILMPPDGYMKKVEDICRRHGALLICDEVICGFGRTGEPFGFMHYGVKP DIITMAKGITSAYLPLSATAVKRDIFEAYQGEAPYDRFRHVNTFGGSPAACALALKNL QIMEDEQLIQRSRDLGAKLLGELQALREHPAVGDVRGKGLLIGIELVKDKLTKEPADA AKVNQVVAACKEKGLIIGKNGDTVAGYNNVIQLAPPFCLTEEDLSFIVKTVKESFQTI *" /label="yhxA CDS" gene 949941..951293 /gene="yhxA" /locus_tag="BSU_09260" /old_locus_tag="BSU09260" /label="yhxA gene" CDS 951321..951899 /gene="glpP" /locus_tag="BSU_09270" /old_locus_tag="BSU09270" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11929549, 23610425, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11929549, 23610425, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="sn-glycerol-3-phosphate responding transcriptionantiterminator" /protein_id="NP_388808.1" /db_xref="EnsemblGenomes-Gn:BSU09270" /db_xref="EnsemblGenomes-Tr:CAB12755" /db_xref="GOA:P30300" /db_xref="InterPro:IPR006699" /db_xref="InterPro:IPR035928" /db_xref="SubtiList:BG10185" /db_xref="UniProtKB/Swiss-Prot:P30300" /translation="MMSFHNQPILPAIRNMKQFDEFLNSSFSYGVILDIHLGQLKGVI KEAQKHGKNMMVHVDLIQGIKHDEYGAEFICQDIKPAGIISTRSNVIAKAKQKKIYAI QRLFLLDTSAMEKSMEFIGKHKPDFIEVLPGIVPSLIQEIKEKTGIPIFAGGFIRTEE DVEQALKAGAVAVTTSNTKLWKKYENFLTESD*" /label="glpP CDS" gene 951321..951899 /gene="glpP" /locus_tag="BSU_09270" /old_locus_tag="BSU09270" /label="glpP gene" promotor_-35 951894..951901 /Source="Nicolas_upshift_promotors" /id="U728" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.605394605394605" /psig="0.998001998001998" /xcortree=276 /SigmaFactorBS="aaatatgaaaactttttgacggaaagtGATTGACAccgcttt catgcacTGATACAATTGCACTAGGTTaatacattgtgatggagaactcggagaccac a" /listShort="S321, glpF, glpK, S322, glpD, S323, pgcA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 951916..951935 /Source="Nicolas_upshift_promotors" /id="U728" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.605394605394605" /psig="0.998001998001998" /xcortree=276 /SigmaFactorBS="aaatatgaaaactttttgacggaaagtGATTGACAccgcttt catgcacTGATACAATTGCACTAGGTTaatacattgtgatggagaactcggagaccac a" /listShort="S321, glpF, glpK, S322, glpD, S323, pgcA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 951927 /Source="Nicolas_upshifts" /id="U728" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.605394605394605" /psig="0.998001998001998" /xcortree=276 /SigmaFactorBS="aaatatgaaaactttttgacggaaagtGATTGACAccgcttt catgcacTGATACAATTGCACTAGGTTaatacattgtgatggagaactcggagaccac a" /listShort="S321, glpF, glpK, S322, glpD, S323, pgcA" /GFF_Attribute="listLong" /label="upshifts" downshifts 951942 /Source="Nicolas_upshifts" /id="D479" /incds=0 /nref=3 /ntot=39 /MaxReadThrough="8.20986" /MaxDrop="2.99328" /score="6.07464219" /energy="-10" /TU="U727,U728" /idTUdmin="U726" /TUdmin=2215 /isTUend="FALSE" /label="downshifts" S_feature 951987..952077 /Source="Nicolas_S_feature" /locus_tag="new_1002410_1002500" /HighExp="Diami, T0.30H, G150, Oxctl, Gly, Paraq, dia5, BC, B60, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S321" CDS 952078..952902 /gene="glpF" /locus_tag="BSU_09280" /old_locus_tag="BSU09280" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11929549, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11929549, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glycerol permease" /protein_id="NP_388809.1" /db_xref="EnsemblGenomes-Gn:BSU09280" /db_xref="EnsemblGenomes-Tr:CAB12756" /db_xref="GOA:P18156" /db_xref="InterPro:IPR000425" /db_xref="InterPro:IPR022357" /db_xref="InterPro:IPR023271" /db_xref="SubtiList:BG10186" /db_xref="UniProtKB/Swiss-Prot:P18156" /translation="MTAFWGEVIGTMLLIIFGAGVCAGVNLKKSLSFQSGWIVVVFGW GLGVAMAAYAVGGISGAHLNPALTIALAFVGDFPWKEVPVYIAAQMIGAIIGAVIIYL HYLPHWKSTDDPAAKLGVFSTGPSIPHTFANVLSEVIGTFVLVLGILAIGANQFTEGL NPLIVGFLIVAIGISLGGTTGYAINPARDLGPRIAHAFLPIPGKGSSNWKYAWVPVVG PILGGSFGGVFYNAAFKGHITSSFWIVSVILVVVLLGLYVYTKSHSAKTLSNSKYI*" /label="glpF CDS" gene 952078..952902 /gene="glpF" /locus_tag="BSU_09280" /old_locus_tag="BSU09280" /label="glpF gene" CDS 952921..954411 /gene="glpK" /locus_tag="BSU_09290" /old_locus_tag="BSU09290" /EC_number="2.7.1.30" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9972264, 10920256, 11929549, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycerol kinase (sn-glycerol-3-phosphate generating)" /protein_id="NP_388810.2" /db_xref="EnsemblGenomes-Gn:BSU09290" /db_xref="EnsemblGenomes-Tr:CAB12757" /db_xref="GOA:P18157" /db_xref="InterPro:IPR000577" /db_xref="InterPro:IPR005999" /db_xref="InterPro:IPR018483" /db_xref="InterPro:IPR018484" /db_xref="InterPro:IPR018485" /db_xref="SubtiList:BG10187" /db_xref="UniProtKB/Swiss-Prot:P18157" /translation="METYILSLDQGTTSSRAILFNKEGKIVHSAQKEFTQYFPHPGWV EHNANEIWGSVLAVIASVISESGISASQIAGIGITNQRETTVVWDKDTGSPVYNAIVW QSRQTSGICEELREKGYNDKFREKTGLLIDPYFSGTKVKWILDNVEGAREKAEKGELL FGTIDTWLIWKMSGGKAHVTDYSNASRTLMFNIYDLKWDDELLDILGVPKSMLPEVKP SSHVYAETVDYHFFGKNIPIAGAAGDQQSALFGQACFEEGMGKNTYGTGCFMLMNTGE KAIKSEHGLLTTIAWGIDGKVNYALEGSIFVAGSAIQWLRDGLRMFQDSSLSESYAEK VDSTDGVYVVPAFVGLGTPYWDSDVRGSVFGLTRGTTKEHFIRATLESLAYQTKDVLD AMEADSNISLKTLRVDGGAVKNNFLMQFQGDLLNVPVERPEINETTALGAAYLAGIAV GFWKDRSEIANQWNLDKRFEPELEEEKRNELYKGWQKAVKAAMAFK*" /label="glpK CDS" gene 952921..954411 /gene="glpK" /locus_tag="BSU_09290" /old_locus_tag="BSU09290" /label="glpK gene" promotor_-35 953722..953728 /Source="Nicolas_upshift_promotors" /id="U729" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=149 /SigmaFactorBS="gcatggggaaaaacacttacggcacaggaTGTTTCAtgctga tgaataccGGGGAAAAAGCAATTAAGTCcgaacatgggcttttgacaacaatcgcttg g" /listShort="S322, glpD, S323" /listLong="pgcA" /label="promotor_-35" promotor_-10 953743..953762 /Source="Nicolas_upshift_promotors" /id="U729" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=149 /SigmaFactorBS="gcatggggaaaaacacttacggcacaggaTGTTTCAtgctga tgaataccGGGGAAAAAGCAATTAAGTCcgaacatgggcttttgacaacaatcgcttg g" /listShort="S322, glpD, S323" /listLong="pgcA" /label="promotor_-10" upshifts 953753 /Source="Nicolas_upshifts" /id="U729" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=149 /SigmaFactorBS="gcatggggaaaaacacttacggcacaggaTGTTTCAtgctga tgaataccGGGGAAAAAGCAATTAAGTCcgaacatgggcttttgacaacaatcgcttg g" /listShort="S322, glpD, S323" /listLong="pgcA" /label="upshifts" S_feature 954412..954500 /Source="Nicolas_S_feature" /locus_tag="new_1004835_1004923" /HighExp="Sw, Etha, Salt, G150, Gly, Diami, T0.30H, B60, BC, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigA" /TUlongPSig=1 /label="S322" downshifts 954457 /Source="Nicolas_upshifts" /id="D480" /incds=0 /nref=34 /ntot=91 /MaxReadThrough="7.63856" /MaxDrop="5.2045" /score="21.1943866" /energy="-28.7" /TU="U728,U729" /idTUdmin="U727" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_no_box 954463..954563 /Source="Nicolas_upshift_promotors" /id="U730" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.566433566433566" /psig="0.154845154845155" /xcortree=277 /SigmaFactorBS="aggagagaccacagcaccaaagtgtaagcatgcactttggct gttgtggtctctttttctatttaccgtgacaacaaggaggaaacgtaatgatgaatca t" /listShort="glpD, S323, pgcA" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 954523 /Source="Nicolas_upshifts" /id="U730" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.566433566433566" /psig="0.154845154845155" /xcortree=277 /SigmaFactorBS="aggagagaccacagcaccaaagtgtaagcatgcactttggct gttgtggtctctttttctatttaccgtgacaacaaggaggaaacgtaatgatgaatca t" /listShort="glpD, S323, pgcA" /GFF_Attribute="listLong" /label="upshifts" CDS 954552..956219 /gene="glpD" /locus_tag="BSU_09300" /old_locus_tag="BSU09300" /EC_number="1.1.3.21" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2127799, 8825777, 9595668, 10633102, 18946204" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2127799, 8825777, 9595668, 10633102, 18946204; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sn-glycerol-3-phosphate oxidase (FAD-dependent)" /protein_id="NP_388811.2" /db_xref="EnsemblGenomes-Gn:BSU09300" /db_xref="EnsemblGenomes-Tr:CAB12758" /db_xref="GOA:P18158" /db_xref="InterPro:IPR000447" /db_xref="InterPro:IPR006076" /db_xref="InterPro:IPR031656" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG10188" /db_xref="UniProtKB/Swiss-Prot:P18158" /translation="MMNHQFSSLERDRMLTDMTKKTYDLFIIGGGITGAGTALDAASR GMKVALSEMQDFAAGTSSRSTKLVHGGLRYLKQFEVKMVAEVGKERAIVYENGPHVTT PEWMLLPFHKGGTFGSFTTSIGLRVYDFLAGVKKSERRSMLSAKETLQKEPLVKKDGL KGGGYYVEYRTDDARLTIEVMKEAVKFGAEPVNYSKVKELLYEKGKAVGVLIEDVLTK KEYKVYAKKIVNATGPWVDQLREKDHSKNGKHLQHTKGIHLVFDQSVFPLKQAVYFDT PDGRMVFAIPREGKTYVGTTDTVYKEALEHPRMTTEDRDYVIKSINYMFPELNITAND IESSWAGLRPLIHEEGKDPSEISRKDEIWTSDSGLITIAGGKLTGYRKMAEHIVDLVR DRLKEEGEKDFGPCKTKNMPISGGHVGGSKNLMSFVTAKTKEGIAAGLSEKDAKQLAI RYGSNVDRVFDRVEALKDEAAKRNIPVHILAEAEYSIEEEMTATPADFFVRRTGRLFF DINWVRTYKDAVIDFMSERFQWDEQAKNKHTENLNKLLHDAVVPLEQ*" /label="glpD CDS" gene 954552..956219 /gene="glpD" /locus_tag="BSU_09300" /old_locus_tag="BSU09300" /label="glpD gene" promotor_-35 955981..955986 /Source="Nicolas_upshift_promotors" /id="U731" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1176 /SigmaFactorBS="aaagatgaggccgcgaaacgcaacattccggTTCATAttctt gctgaggcaGAATACAGTATAGAAGAAGagatgactgcaacccctgctgacttctttg t" /listShort="S323" /listLong="pgcA" /label="promotor_-35" promotor_-10 956001..956019 /Source="Nicolas_upshift_promotors" /id="U731" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1176 /SigmaFactorBS="aaagatgaggccgcgaaacgcaacattccggTTCATAttctt gctgaggcaGAATACAGTATAGAAGAAGagatgactgcaacccctgctgacttctttg t" /listShort="S323" /listLong="pgcA" /label="promotor_-10" upshifts 956010 /Source="Nicolas_upshifts" /id="U731" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1176 /SigmaFactorBS="aaagatgaggccgcgaaacgcaacattccggTTCATAttctt gctgaggcaGAATACAGTATAGAAGAAGagatgactgcaacccctgctgacttctttg t" /listShort="S323" /listLong="pgcA" /label="upshifts" promotor_-35 956064..956070 /Source="Nicolas_upshift_promotors" /id="U732" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=255 /SigmaFactorBS="actgcaacccctgctgacttctttgtccgcagaacgggaCGT TTATtttttgatatcaattGGGTAAGAACATATAAAGAtgccgttattgattttatga g" /listShort="S323, pgcA, S324, yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 956085 /Source="Nicolas_upshifts" /id="U732" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=255 /SigmaFactorBS="actgcaacccctgctgacttctttgtccgcagaacgggaCGT TTATtttttgatatcaattGGGTAAGAACATATAAAGAtgccgttattgattttatga g" /listShort="S323, pgcA, S324, yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 956086..956104 /Source="Nicolas_upshift_promotors" /id="U732" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=255 /SigmaFactorBS="actgcaacccctgctgacttctttgtccgcagaacgggaCGT TTATtttttgatatcaattGGGTAAGAACATATAAAGAtgccgttattgattttatga g" /listShort="S323, pgcA, S324, yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 956187 /Source="Nicolas_upshifts" /id="D481" /incds=0 /nref=13 /ntot=60 /MaxReadThrough="6.57605" /MaxDrop="4.31183" /score="11.5542287" /energy="-11.4" /TU="U728,U729,U730,U731,U732" /idTUdmin="U729" /TUdmin="-118" /isTUend="FALSE" /label="downshifts" S_feature 956232..956305 /Source="Nicolas_S_feature" /locus_tag="new_1006655_1006728" /HighExp="G150, Etha, Oxctl, H2O2, Gly, Diami, Paraq, Salt, B36, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigEF, Sig-, SigB, SigA" /TUshortPSig="1, 0.995, 0.155, 1, 0.998" /TUlongSig="SigA" /TUlongPSig=1 /label="S323" promotor_-35 956287..956294 /Source="Nicolas_upshift_promotors" /id="U733" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig="0.998001998001998" /xcortree=1942 /SigmaFactorBS="atttctttttacgtgccgaaagggggagatctcaggttatCA AGTGACagaggcacccgctTCATATAAAATAATGGCATAagctgatacataggaggac g" /listShort="pgcA, S324, yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 956307 /Source="Nicolas_upshifts" /id="U733" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig="0.998001998001998" /xcortree=1942 /SigmaFactorBS="atttctttttacgtgccgaaagggggagatctcaggttatCA AGTGACagaggcacccgctTCATATAAAATAATGGCATAagctgatacataggaggac g" /listShort="pgcA, S324, yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 956308..956327 /Source="Nicolas_upshift_promotors" /id="U733" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig="0.998001998001998" /xcortree=1942 /SigmaFactorBS="atttctttttacgtgccgaaagggggagatctcaggttatCA AGTGACagaggcacccgctTCATATAAAATAATGGCATAagctgatacataggaggac g" /listShort="pgcA, S324, yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 956351..958096 /gene="pgcA" /locus_tag="BSU_09310" /old_locus_tag="BSU09310" /EC_number="5.4.2.2" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15640167, 17662947, 24097947, 26735940, 27684739" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15640167, 17662947, 24097947, 26735940, 27684739; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alpha-phosphoglucomutase" /protein_id="NP_388812.2" /db_xref="EnsemblGenomes-Gn:BSU09310" /db_xref="EnsemblGenomes-Tr:CAB12759" /db_xref="GOA:P18159" /db_xref="InterPro:IPR005841" /db_xref="InterPro:IPR005843" /db_xref="InterPro:IPR005844" /db_xref="InterPro:IPR005845" /db_xref="InterPro:IPR005846" /db_xref="InterPro:IPR016055" /db_xref="InterPro:IPR016066" /db_xref="InterPro:IPR036900" /db_xref="SubtiList:BG10189" /db_xref="UniProtKB/Swiss-Prot:P18159" /translation="MTWRKSYERWKQTEHLDLELKERLIELEGDEQALEDCFYKDLEF GTGGMRGEIGAGTNRMNIYTVRKASAGFAAYISKQGEEAKKRGVVIAYDSRHKSPEFA MEAAKTLATQGIQTYVFDELRPTPELSFAVRQLNAYGGIVVTASHNPPEYNGYKVYGD DGGQLPPKEADIVIEQVNAIENELTITVDEENKLKEKGLIKIIGEDIDKVYTEKLTSI SVHPELSEEVDVKVVFTPLHGTANKPVRRGLEALGYKNVTVVKEQELPDSNFSTVTSP NPEEHAAFEYAIKLGEEQNADILIATDPDADRLGIAVKNDQGKYTVLTGNQTGALLLH YLLSEKKKQGILPDNGVVLKTIVTSEIGRAVASSFGLDTIDTLTGFKFIGEKIKEYEA SGQYTFQFGYEESYGYLIGDFARDKDAIQAALLAVEVCAFYKKQGMSLYEALINLFNE YGFYREGLKSLTLKGKQGAEQIEAILASFRQNPPQKMAGKQVVTAEDYAVSKRTLLTE SKEEAIDLPKSNVLKYFLEDGSWFCLRPSGTEPKVKFYFAVKGSSLEDSEKRLAVLSE DVMKTVDEIVESTAK*" /label="pgcA CDS" gene 956351..958096 /gene="pgcA" /locus_tag="BSU_09310" /old_locus_tag="BSU09310" /label="pgcA gene" downshifts 958085 /Source="Nicolas_upshifts" /id="D482" /incds=0 /nref=227 /ntot=264 /MaxReadThrough="4.80136" /MaxDrop="5.89896" /score="26.7163878" /energy="-13" /TU="U732,U733" /idTUdmin="U728" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" S_feature 958130..958199 /Source="Nicolas_S_feature" /locus_tag="new_1008553_1008622" /HighExp="Etha, H2O2, B36, dia15, Paraq, G150, LoTm, S8, Oxctl, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S324" misc_feature 958201..958220 /Source="Nicolas_upshift_promotors" /id="U734" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.62037962037962" /psig="0.998001998001998" /xcortree=3137 /SigmaFactorBS="tttctcatccaaaagtctgaaagaaaatcatcctacaagtga agcaatgaaatacaaaaaACTGGTATAATCTTAAATACaagatcaatgccggagtgag a" /listShort="yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 958201 /Source="Nicolas_upshifts" /id="U734" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.62037962037962" /psig="0.998001998001998" /xcortree=3137 /SigmaFactorBS="tttctcatccaaaagtctgaaagaaaatcatcctacaagtga agcaatgaaatacaaaaaACTGGTATAATCTTAAATACaagatcaatgccggagtgag a" /listShort="yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="upshifts" CDS 958245..959384 /gene="yhcY" /locus_tag="BSU_09320" /old_locus_tag="BSU09320" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 16816187, 16267314, 20639339, 21335452" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 16816187, 16267314, 20639339, 21335452; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YhcZ]" /protein_id="NP_388813.1" /db_xref="EnsemblGenomes-Gn:BSU09320" /db_xref="EnsemblGenomes-Tr:CAB12760" /db_xref="GOA:O07527" /db_xref="InterPro:IPR003018" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR029016" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG13005" /db_xref="UniProtKB/Swiss-Prot:O07527" /translation="MSKTRMEKLKTLKTIAETLNQGHDIKATLDEVLKELLSLTNLQS GWIFLIEEDGSYTLAADAYLPPALSRKEKVLMCEGECYCLTKFNNGGLRKAANIMNCK RIESAENLHCFDTEGITHHATVPLEDGDRRFGLLNVAAAGKTMFDEEELHLLESVAFQ IGTAIQRMRLSEYQQKNALLMERNRLAQELHDSVNQMLFSVSLTAKAAKTLTKDENLQ QMIDFIQNLSQDALAEMKALIWQLRPGGLEKGLAEAIKSYGALIGLKIIFTQKGCPVL TDEQEHMLWRVVQEALNNCKKHAGTDTAYVSLTASLCHAELDIIDHGAGFRYEAHAGL PSLGIKGMKERAEKAGAKFWIESALGTGTKLSIRLPLKSRKGGAV*" /label="yhcY CDS" gene 958245..959384 /gene="yhcY" /locus_tag="BSU_09320" /old_locus_tag="BSU09320" /label="yhcY gene" CDS 959381..960025 /gene="yhcZ" /locus_tag="BSU_09330" /old_locus_tag="BSU09330" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 16816187, 16267314, 20639339, 21335452" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 16816187, 16267314, 20639339, 21335452; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YhcY]" /protein_id="NP_388814.1" /db_xref="EnsemblGenomes-Gn:BSU09330" /db_xref="EnsemblGenomes-Tr:CAB12761" /db_xref="GOA:O07528" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG13006" /db_xref="UniProtKB/Swiss-Prot:O07528" /translation="MKIVIADDHHVVRKGLRFFFATQDDIEVVGEAATGLEALRVIEE TKPDLVLMDLSMPEMDGIQAIKKAIQQFPDTNIIVLTSYSDQEHVIPALQAGAKAYQL KDTEPEELVKTRQVHGGEYKLSTAIMPHVLTHMKNQHDPEKEKYYQLTRREKDVLTEI ANGKSNKEIAAALFISEKTVKTHVSNLLAKLEVADRTQAALFAVKYNLNGEISK*" /label="yhcZ CDS" gene 959381..960025 /gene="yhcZ" /locus_tag="BSU_09330" /old_locus_tag="BSU09330" /label="yhcZ gene" CDS 960022..960546 /gene="azr" /locus_tag="BSU_09340" /old_locus_tag="BSU09340" /EC_number="1.7.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15184374, 16816187, 20639339; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oxidoreductase, NAD(P)H-FMN and ferric iron reductase (azoreductase)" /protein_id="NP_388815.1" /db_xref="EnsemblGenomes-Gn:BSU09340" /db_xref="EnsemblGenomes-Tr:CAB12762" /db_xref="GOA:O07529" /db_xref="InterPro:IPR005025" /db_xref="InterPro:IPR029039" /db_xref="PDB:1NNI" /db_xref="PDB:2GSW" /db_xref="PDB:3GFQ" /db_xref="PDB:3GFR" /db_xref="PDB:3GFS" /db_xref="SubtiList:BG13007" /db_xref="UniProtKB/Swiss-Prot:O07529" /translation="MNMLVINGTPRKHGRTRIAASYIAALYHTDLIDLSEFVLPVFNG EAEQSELLKVQELKQRVTKADAIVLLSPEYHSGMSGALKNALDFLSSEQFKYKPVALL AVAGGGKGGINALNNMRTVMRGVYANVIPKQLVLDPVHIDVENATVAENIKESIKELV EELSMFAKAGNPGV*" /label="azr CDS" gene 960022..960546 /gene="azr" /locus_tag="BSU_09340" /old_locus_tag="BSU09340" /label="azr gene" downshifts 960511 /Source="Nicolas_upshifts" /id="D483" /incds=0 /nref=72 /ntot=215 /MaxReadThrough="2.90096" /MaxDrop="4.78561" /score="27.1269177" /energy="-17.2" /TU="NA" /idTUdmin="U734" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(960561..960803) /gene="yhdB" /locus_tag="BSU_09350" /old_locus_tag="BSU09350" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388816.1" /db_xref="EnsemblGenomes-Gn:BSU09350" /db_xref="EnsemblGenomes-Tr:CAB12763" /db_xref="InterPro:IPR025431" /db_xref="SubtiList:BG13008" /db_xref="UniProtKB/Swiss-Prot:O07530" /translation="MDYADYDKALYYTHRSQWDNLLILMVRTEDDLLSKRIEHFLHAY HFEQDYAVLEKMLYSLLRYIDHATELTYEDQIALLT*" /label="yhdB CDS" gene complement(960561..960803) /gene="yhdB" /locus_tag="BSU_09350" /old_locus_tag="BSU09350" /label="yhdB gene" downshifts complement(960582) /Source="Nicolas_upshifts" /id="D484" /incds=0 /nref=39 /ntot=84 /MaxReadThrough="-0.0235599999999998" /MaxDrop="7.78706" /score="12.0066876" /energy="-17.2" /TU="NA" /idTUdmin="U735" /TUdmin="-17" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(960839..960850) /Source="Nicolas_upshift_promotors" /id="U735" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.556443556443556" /psig="0.556443556443556" /xcortree=833 /SigmaFactorBS="attgctacccctttactgacgcagacggcaagttttgccCCG TCAATaacagaggatgcgGCATAAACTAATcatgaacttctcacccaagaaaggagaa g" /listShort="yhdB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(960850) /Source="Nicolas_upshifts" /id="U735" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.556443556443556" /psig="0.556443556443556" /xcortree=833 /SigmaFactorBS="attgctacccctttactgacgcagacggcaagttttgccCCG TCAATaacagaggatgcgGCATAAACTAATcatgaacttctcacccaagaaaggagaa g" /listShort="yhdB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(960864..960871) /Source="Nicolas_upshift_promotors" /id="U735" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.556443556443556" /psig="0.556443556443556" /xcortree=833 /SigmaFactorBS="attgctacccctttactgacgcagacggcaagttttgccCCG TCAATaacagaggatgcgGCATAAACTAATcatgaacttctcacccaagaaaggagaa g" /listShort="yhdB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 960938..960944 /Source="Nicolas_upshift_promotors" /id="U736" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=929 /SigmaFactorBS="aatatgagggagacataaaatcaaaatgccTGAATGAagata tcgcttttGGTAAACCTATGagggaatatattctgggtacaggagactgaaaaaatga a" /listShort="yhdC, S325" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 960958..960969 /Source="Nicolas_upshift_promotors" /id="U736" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=929 /SigmaFactorBS="aatatgagggagacataaaatcaaaatgccTGAATGAagata tcgcttttGGTAAACCTATGagggaatatattctgggtacaggagactgaaaaaatga a" /listShort="yhdC, S325" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 960968 /Source="Nicolas_upshifts" /id="U736" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=929 /SigmaFactorBS="aatatgagggagacataaaatcaaaatgccTGAATGAagata tcgcttttGGTAAACCTATGagggaatatattctgggtacaggagactgaaaaaatga a" /listShort="yhdC, S325" /GFF_Attribute="listLong" /label="upshifts" CDS 961004..961327 /gene="yhdC" /locus_tag="BSU_09360" /old_locus_tag="BSU09360" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_388817.1" /db_xref="EnsemblGenomes-Gn:BSU09360" /db_xref="EnsemblGenomes-Tr:CAB12764" /db_xref="InterPro:IPR024987" /db_xref="SubtiList:BG13009" /db_xref="UniProtKB/Swiss-Prot:O07531" /translation="MKSLPYTIALLFCGLIIVSMAAKGHSTDTDESVQKWEQLAWSKI QDEYKGASFSDYAYMGRTEVNDQQTKDVFRVTVRQKDDTFSVRAEVYFHPVTNHMISI NVFRL*" /label="yhdC CDS" gene 961004..961327 /gene="yhdC" /locus_tag="BSU_09360" /old_locus_tag="BSU09360" /label="yhdC gene" S_feature 961328..963194 /Source="Nicolas_S_feature" /locus_tag="new_1011751_1013617" /HighExp="S8, S5, S7, S6, S4, C30, Sw, ferm, S3, BC" /AntisenseName="lytF" /AntisenseCor="-0.65564579825076796" /AntisenseRegPval="-33.700000000000003" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S325" CDS complement(961369..962835) /gene="lytF" /locus_tag="BSU_09370" /old_locus_tag="BSU09370" /EC_number="3.4.-.-" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10206711, 14594841, 18761694, 18761696, 23091053, 25288647" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10206711, 14594841, 18761694, 18761696, 23091053, 25288647; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="gamma-D-glutamate-meso-diaminopimelate muropeptidase (major autolysin, vegetative)" /protein_id="NP_388818.2" /db_xref="EnsemblGenomes-Gn:BSU09370" /db_xref="EnsemblGenomes-Tr:CAB12776" /db_xref="GOA:O07532" /db_xref="InterPro:IPR000064" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG13010" /db_xref="UniProtKB/Swiss-Prot:O07532" /translation="MKKKLAAGLTASAIVGTTLVVTPAEAATIKVKSGDSLWKLAQTY NTSVAALTSANHLSTTVLSIGQTLTIPGSKSSTSSSTSSSTTKKSGSSVYTVKSGDSL WLIANEFKMTVQELKKLNGLSSDLIRAGQKLKVSGTVSSSSSSSKKSNSNKSSSSSSK SSSNKSSSSSSSTGTYKVQLGDSLWKIANKVNMSIAELKVLNNLKSDTIYVNQVLKTK SSGSDTSSKDNSSKSNQTSATTKYTVKSGDSLWKIANNYNLTVQQIRNINNLKSDVLY VGQVLKLTGKASSGSSSSSSSSSNASSGTTTTYTVKSGDSLWVIAQKFNVTAQQIREK NNLKTDVLQVGQKLVISGKASSSSSSGSSNTTSSTSAKINTMISAAKAQLGVPYRWGG TTPSGFDCSGFIYYVLNKVTSVSRLTAAGYWNTMKSVSQPAVGDFVFFSTYKAGPSHV GIYLGNGEFINANDSGVVISNMNNSYWKQRYLGAKRYF*" /label="lytF CDS" gene complement(961369..962835) /gene="lytF" /locus_tag="BSU_09370" /old_locus_tag="BSU09370" /label="lytF gene" downshifts complement(961381) /Source="Nicolas_upshifts" /id="D485" /incds=0 /nref=121 /ntot=216 /MaxReadThrough="2.34529" /MaxDrop="4.33563" /score="24.6732339" /energy="-14.2" /TU="NA" /idTUdmin="U737" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" downshifts complement(961468) /Source="Nicolas_upshifts" /id="D486" /incds=1 /nref=1 /ntot=87 /MaxReadThrough="5.73069" /MaxDrop="2.6306" /score="24.6732339" /energy="-14.2" /TU="U737" /idTUdmin="U737" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(962875..962893) /Source="Nicolas_upshift_promotors" /id="U737" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2806 /SigmaFactorBS="ttgttaagataatttggctatttttataaaaagGCAAAACGa tgagacaaatgtGCCGATATAAAAAAGAAACagcaaatgcaaaatcattgggggaaaa a" /listShort="lytF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(962887) /Source="Nicolas_upshifts" /id="U737" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2806 /SigmaFactorBS="ttgttaagataatttggctatttttataaaaagGCAAAACGa tgagacaaatgtGCCGATATAAAAAAGAAACagcaaatgcaaaatcattgggggaaaa a" /listShort="lytF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(962907..962914) /Source="Nicolas_upshift_promotors" /id="U737" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2806 /SigmaFactorBS="ttgttaagataatttggctatttttataaaaagGCAAAACGa tgagacaaatgtGCCGATATAAAAAAGAAACagcaaatgcaaaatcattgggggaaaa a" /listShort="lytF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(962988..963428) /gene="nsrR" /locus_tag="BSU_09380" /old_locus_tag="BSU09380" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16885456, 19006327, 21091510, 26887943, 27778474, 28425466, 28439033" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16885456, 19006327, 21091510, 26887943, 27778474, 28425466, 28439033; Product type r: regulator" /codon_start=1 /transl_table=11 /product="NO-dependent activator of the ResDE regulon (Fe-S NO binding site)" /protein_id="NP_388819.1" /db_xref="EnsemblGenomes-Gn:BSU09380" /db_xref="EnsemblGenomes-Tr:CAB12777" /db_xref="GOA:O07573" /db_xref="InterPro:IPR000944" /db_xref="InterPro:IPR030489" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13011" /db_xref="UniProtKB/Swiss-Prot:O07573" /translation="MKLTNYTDYSLRVLIFLAAERPGELSNIKQIAETYSISKNHLMK VIYRLGQLGYVETIRGRGGGIRLGMDPEDINIGEVVRKTEDDFNIVECFDANKNLCVI SPVCGLKHVLNEALLAYLAVLDKYTLRDLVKNKEDIMKLLKMKE*" /label="nsrR CDS" gene complement(962988..963428) /gene="nsrR" /locus_tag="BSU_09380" /old_locus_tag="BSU09380" /label="nsrR gene" downshifts complement(963018) /Source="Nicolas_upshifts" /id="D487" /incds=0 /nref=205 /ntot=265 /MaxReadThrough="3.11158" /MaxDrop="6.87147" /score="5.96186156" /energy="-7.8" /TU="U739" /idTUdmin="U740" /TUdmin="-10" /isTUend="TRUE" /label="downshifts" promotor_-35 963416..963422 /Source="Nicolas_upshift_promotors" /id="U738" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.904095904095904" /psig="0.904095904095904" /xcortree=408 /SigmaFactorBS="cagaaaaatcaacactcttaatgaataatctgtataatTGGT TAActtcataataagaCCTCAGAATAAGacattttctatatcttatcataatcgattg a" /listShort="S326" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 963436..963447 /Source="Nicolas_upshift_promotors" /id="U738" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.904095904095904" /psig="0.904095904095904" /xcortree=408 /SigmaFactorBS="cagaaaaatcaacactcttaatgaataatctgtataatTGGT TAActtcataataagaCCTCAGAATAAGacattttctatatcttatcataatcgattg a" /listShort="S326" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 963438..963548 /Source="Nicolas_S_feature" /locus_tag="new_1013861_1013971" /HighExp="S8, S7, S4, Sw, S5, S6, BC, B60, nit, Pyr" /AntisenseName="ygxB" /AntisenseCor="-0.211236686077168" /AntisenseRegPval="-3.3" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.904" /TUlongSig="NA" /TUlongPSig="NA" /label="S326" upshifts 963438 /Source="Nicolas_upshifts" /id="U738" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.904095904095904" /psig="0.904095904095904" /xcortree=408 /SigmaFactorBS="cagaaaaatcaacactcttaatgaataatctgtataatTGGT TAActtcataataagaCCTCAGAATAAGacattttctatatcttatcataatcgattg a" /listShort="S326" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(963450..963469) /Source="Nicolas_upshift_promotors" /id="U739" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3120 /SigmaFactorBS="catgcacccagctgggtgcatgttttttaattcctttttTTT CATTtttcaatcgatTATGATAAGATATAGAAAATgtcttattctgaggtcttattat g" /listShort="nsrR, lytF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(963466) /Source="Nicolas_upshifts" /id="U739" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3120 /SigmaFactorBS="catgcacccagctgggtgcatgttttttaattcctttttTTT CATTtttcaatcgatTATGATAAGATATAGAAAATgtcttattctgaggtcttattat g" /listShort="nsrR, lytF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(963481..963487) /Source="Nicolas_upshift_promotors" /id="U739" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3120 /SigmaFactorBS="catgcacccagctgggtgcatgttttttaattcctttttTTT CATTtttcaatcgatTATGATAAGATATAGAAAATgtcttattctgaggtcttattat g" /listShort="nsrR, lytF" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 963507 /Source="Nicolas_upshifts" /id="D488" /incds=0 /nref=10 /ntot=68 /MaxReadThrough="1.05981" /MaxDrop="6.25571" /score="22.5171081" /energy="-11.6" /TU="NA" /idTUdmin="U738" /TUdmin=3 /isTUend="TRUE" /label="downshifts" CDS complement(963535..965193) /gene="ygxB" /locus_tag="BSU_09390" /old_locus_tag="BSU09390" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_388820.1" /db_xref="EnsemblGenomes-Gn:BSU09390" /db_xref="EnsemblGenomes-Tr:CAB12778" /db_xref="GOA:P37874" /db_xref="InterPro:IPR008910" /db_xref="SubtiList:BG10181" /db_xref="UniProtKB/Swiss-Prot:P37874" /translation="MYEPARQKMIVSLGQEKIPPAHSSVCLLDKWVNTHHTTKKERYQ LNVADVFSSYLSKLPNVIIALLVLLIGWAIAKIIEKAVYKGLSKTKIDDKLFAGKKPS RYSSEKVISKVVYFIALIIVFILFFNILHLTTVASPFVSMLSAIAAAIPSVLKAGLIL LLGWAAASVLSFLVKKIGMKLNTSDKLRKWNLVSEGKDIHQAVNTASQIVFYLVLLVF LPGVLSSLKISGISGPFTNMMESVLAFLPKLFAAALIVLIGWLVARLVRDIITNFLAS IGTERFAARMGLSIYLKDTSLSAVIGTIAYVLIMIPVVISALDQLDVAGISKPAVSML NTILNMLPNIMIAIVLVLAGIWAGKWVKSMVSGLLHRAGFDSVLGKMGMEAGTPAKLS LSQVVGMIAQIIVILLFTAEALQIVRLHFLVEIATGIIAYLPNVLVAVFILGLGLYAG ELVRKVLASMIKGQEFKSLAPIAKYTIIALAFFMALDQLGVAATIVNSAFIIVLSGFA LAFGLSFGLGGKDFASRYLSTFERKMQNTEIEKNRKNQNPPNDM*" /label="ygxB CDS" gene complement(963535..965193) /gene="ygxB" /locus_tag="BSU_09390" /old_locus_tag="BSU09390" /label="ygxB gene" downshifts complement(963540) /Source="Nicolas_upshifts" /id="D489" /incds=0 /nref=6 /ntot=40 /MaxReadThrough="8.34865" /MaxDrop="5.55332" /score="-5.46969987" /energy="-14.5" /TU="U740" /idTUdmin="U740" /TUdmin="-532" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(965084..965102) /Source="Nicolas_upshift_promotors" /id="U740" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=189 /SigmaFactorBS="agtctcactcgggcaagaaaaaattcccccggcacattcatc TGTTTGCttattggataagtGGGTAAACACACACCATACtacgaaaaaggagcgatac c" /listShort="nsrR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(965104) /Source="Nicolas_upshifts" /id="U740" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=189 /SigmaFactorBS="agtctcactcgggcaagaaaaaattcccccggcacattcatc TGTTTGCttattggataagtGGGTAAACACACACCATACtacgaaaaaggagcgatac c" /listShort="nsrR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(965116..965122) /Source="Nicolas_upshift_promotors" /id="U740" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=189 /SigmaFactorBS="agtctcactcgggcaagaaaaaattcccccggcacattcatc TGTTTGCttattggataagtGGGTAAACACACACCATACtacgaaaaaggagcgatac c" /listShort="nsrR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 965165..965170 /Source="Nicolas_upshift_promotors" /id="U741" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1163 /SigmaFactorBS="gaattttttcttgcccgagtgagactATCATCttttgtctgg cgggcTCATACATTATAGATAAGTccaagtaggggggattcggttgaacgcggaggag a" /listShort="spoVR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 965186..965204 /Source="Nicolas_upshift_promotors" /id="U741" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1163 /SigmaFactorBS="gaattttttcttgcccgagtgagactATCATCttttgtctgg cgggcTCATACATTATAGATAAGTccaagtaggggggattcggttgaacgcggaggag a" /listShort="spoVR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 965199 /Source="Nicolas_upshifts" /id="U741" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1163 /SigmaFactorBS="gaattttttcttgcccgagtgagactATCATCttttgtctgg cgggcTCATACATTATAGATAAGTccaagtaggggggattcggttgaacgcggaggag a" /listShort="spoVR" /GFF_Attribute="listLong" /label="upshifts" CDS 965224..966630 /gene="spoVR" /locus_tag="BSU_09400" /old_locus_tag="BSU09400" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:8144469, 14680823" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8144469, 14680823; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="involved in spore cortex synthesis (stage V sporulation, conserved in non sporulating bacteria" /protein_id="NP_388821.1" /db_xref="EnsemblGenomes-Gn:BSU09400" /db_xref="EnsemblGenomes-Tr:CAB12779" /db_xref="GOA:P37875" /db_xref="InterPro:IPR007390" /db_xref="SubtiList:BG10182" /db_xref="UniProtKB/Swiss-Prot:P37875" /translation="MNAEEKKGLQRAIEEITEIAKGFGLDFYPMRYEICPAEIIYTFG AYGMPTRFSHWSFGKQFHKMKLHYDLGLSKIYELVINSDPCYAFLLDSNSLIQNKLIV AHVLAHCDFFKNNCRFQNTKRDMVESMAATAERIKHYEQVHGIKEVESFLDAILSIQE HIDPSLVRPKLQWSVDDEEEEIEEAATPYDDLWSLDEKKPKKQVKKSKKPFPPRPEKD ILLFIEEHSRELEPWQRDILTMMREEMLYFWPQLETKIMNEGWASYWHQRIIRELDLT SDEAIEFAKLNAGVVQPSKTGINPYYLGLKIFEDIEKRYNNPTEEMKKMGVQPDSGRE KMFEVREIESDISFIRNYLTKELVMREDLYLFQKQGRDYKIIDKQWKSVRDQLVSMRV NGGFPYLTVNDGDYMKNNELYIKHWYEGIELDLKYLEKVLPYLFQLWGRSVHIESVLE DKEVMFSYDGKGVHRRYL*" /label="spoVR CDS" gene 965224..966630 /gene="spoVR" /locus_tag="BSU_09400" /old_locus_tag="BSU09400" /label="spoVR gene" downshifts 966610 /Source="Nicolas_upshifts" /id="D490" /incds=0 /nref=43 /ntot=84 /MaxReadThrough="1.30719" /MaxDrop="6.74388" /score="26.4488835" /energy="-11.5" /TU="NA" /idTUdmin="U741" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(966660..968045) /gene="phoA" /locus_tag="BSU_09410" /old_locus_tag="BSU09410" /EC_number="3.1.3.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8830275, 10913081, 12897025, 16491025" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8830275, 10913081, 12897025, 16491025; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alkaline phosphatase A" /protein_id="NP_388822.2" /db_xref="EnsemblGenomes-Gn:BSU09410" /db_xref="EnsemblGenomes-Tr:CAB12780" /db_xref="GOA:P19406" /db_xref="InterPro:IPR001952" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="InterPro:IPR018299" /db_xref="SubtiList:BG10183" /db_xref="UniProtKB/Swiss-Prot:P19406" /translation="MKKMSLFQNMKSKLLPIAAVSVLTAGIFAGAELQQTEKASAKKQ DKAEIRNVIVMIGDGMGTPYIRAYRSMKNNGDTPNNPKLTEFDRNLTGMMMTHPDDPD YNITDSAAAGTALATGVKTYNNAIGVDKNGKKVKSVLEEAKQQGKSTGLVATSEINHA TPAAYGAHNESRKNMDQIANSYMDDKIKGKHKIDVLLGGGKSYFNRKDRNLTKEFKQA GYSYVTTKQALKKNKDQQVLGLFADGGLAKALDRDSKTPSLKDMTVSAIDRLNQNKKG FFLMVEGSQIDWAAHDNDTVGAMSEVKDFEQAYKAAIEFAKKDKHTLVIATADHTTGG FTIGANGEKNWHAEPILSAKKTPEFMAKKISEGKPVKDVLARYANLKVTSEEIKSVEA AAQADKSKGASKAIIKIFNTRSNSGWTSTDHTGEEVPVYAYGPGKEKFRGLINNTDQA NIIFKILKTGK*" /label="phoA CDS" gene complement(966660..968045) /gene="phoA" /locus_tag="BSU_09410" /old_locus_tag="BSU09410" /label="phoA gene" downshifts complement(966686) /Source="Nicolas_upshifts" /id="D491" /incds=0 /nref=51 /ntot=178 /MaxReadThrough="1.90638" /MaxDrop="5.795" /score="22.2126775" /energy="-13.2" /TU="NA" /idTUdmin="U742" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(968072) /Source="Nicolas_upshifts" /id="U742" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.94105894105894" /psig="0.035964035964036" /xcortree=8 /SigmaFactorBS="acaaggctttacttattgtttacatgatcaacagccgcaTTT AACAAAGTTtccctaacatgataaacggaatacattaaaggaggcatgaaaaaaatga g" /listShort="phoA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(968074..969605) /Source="Nicolas_S_feature" /locus_tag="new_1018497_1020028_c" /HighExp="Etha, Salt, B60, Heat, M9-stat, T5.0H, T0.30H, T4.0H, T3.30H, T2.30H" /AntisenseName="lytE" /AntisenseCor="-0.65081062481616203" /AntisenseRegPval="-33.1" /CDS_PredictionProba="NA" /TUshortSig="SigWXY, SigA" /TUshortPSig="0.966, 0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S327" misc_feature complement(968082..968093) /Source="Nicolas_upshift_promotors" /id="U742" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.94105894105894" /psig="0.035964035964036" /xcortree=8 /SigmaFactorBS="acaaggctttacttattgtttacatgatcaacagccgcaTTT AACAAAGTTtccctaacatgataaacggaatacattaaaggaggcatgaaaaaaatga g" /listShort="phoA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-35 968201..968208 /Source="Nicolas_upshift_promotors" /id="U743" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.564435564435564" /psig="0.999000999001" /xcortree=3050 /SigmaFactorBS="ttatttgatgtaaagcattcatttttcagaaaaaTCTTTACC tctctgtctttgCATGATATGTTTGTTTAAATaaaaaaactgcggataaccacagctc t" /listShort="S328, lytE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 968221..968240 /Source="Nicolas_upshift_promotors" /id="U743" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.564435564435564" /psig="0.999000999001" /xcortree=3050 /SigmaFactorBS="ttatttgatgtaaagcattcatttttcagaaaaaTCTTTACC tctctgtctttgCATGATATGTTTGTTTAAATaaaaaaactgcggataaccacagctc t" /listShort="S328, lytE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 968227..968514 /Source="Nicolas_S_feature" /locus_tag="new_1018650_1018937" /HighExp="T-5.40H, Cold, LoTm, T-4.40H, UNK1, T5.0H, GM-0.1, T3.30H, S1, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S328" upshifts 968227 /Source="Nicolas_upshifts" /id="U743" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.564435564435564" /psig="0.999000999001" /xcortree=3050 /SigmaFactorBS="ttatttgatgtaaagcattcatttttcagaaaaaTCTTTACC tctctgtctttgCATGATATGTTTGTTTAAATaaaaaaactgcggataaccacagctc t" /listShort="S328, lytE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 968477..968480 /Source="Nicolas_upshift_promotors" /id="U744" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.75924075924076" /psig="0.971028971028971" /xcortree=3027 /SigmaFactorBS="atttgtcacatgaagtcaagaCTATttctgatgggaatcTAT CCTTATAATAGAAATCAataagattaatttaaaaaaagagatacatatatatagagtt a" /listShort="lytE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 968495..968514 /Source="Nicolas_upshift_promotors" /id="U744" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.75924075924076" /psig="0.971028971028971" /xcortree=3027 /SigmaFactorBS="atttgtcacatgaagtcaagaCTATttctgatgggaatcTAT CCTTATAATAGAAATCAataagattaatttaaaaaaagagatacatatatatagagtt a" /listShort="lytE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 968516 /Source="Nicolas_upshifts" /id="U744" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.75924075924076" /psig="0.971028971028971" /xcortree=3027 /SigmaFactorBS="atttgtcacatgaagtcaagaCTATttctgatgggaatcTAT CCTTATAATAGAAATCAataagattaatttaaaaaaagagatacatatatatagagtt a" /listShort="lytE" /GFF_Attribute="listLong" /label="upshifts" CDS 968575..969579 /gene="lytE" /locus_tag="BSU_09420" /old_locus_tag="BSU09420" /EC_number="3.4.-.-" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16855244, 16950129, 9457885, 21541672, 22139507, 27002131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16855244, 16950129, 9457885, 21541672, 22139507, 27002131; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cell wall dl-endopeptidase; phosphatase-associated protein (major autolysin)" /protein_id="NP_388823.2" /db_xref="EnsemblGenomes-Gn:BSU09420" /db_xref="EnsemblGenomes-Tr:CAB12781" /db_xref="GOA:P54421" /db_xref="InterPro:IPR000064" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG11406" /db_xref="UniProtKB/Swiss-Prot:P54421" /translation="MKKQIITATTAVVLGSTLFAGAASAQSIKVKKGDTLWDLSRKYD TTISKIKSENHLRSDIIYVGQTLSINGKSTSSKSSSSSSSSSTYKVKSGDSLWKISKK YGMTINELKKLNGLKSDLLRVGQVLKLKGSTSSSSSSSSKVSSSSTSTYKVKSGDSLS KIASKYGTTVSKLKSLNGLKSDVIYVNQVLKVKGTSTSSSKPASSSSSSSSKTSSTSL NVSKLVSDAKALVGTPYKWGGTTTSGFDCSGFIWYVLNKQTSVGRTSTAGYWSSMKSI ASPSVGDFVFFTTYKSGPSHMGIYIGNNSFIHAGSDGVQISSLNNSYWKPRYLGAKRF *" /label="lytE CDS" gene 968575..969579 /gene="lytE" /locus_tag="BSU_09420" /old_locus_tag="BSU09420" /label="lytE gene" downshifts 969441 /Source="Nicolas_upshifts" /id="D492" /incds=1 /nref=1 /ntot=117 /MaxReadThrough="6.89938" /MaxDrop="2.1687" /score="26.3320532" /energy="-9.8" /TU="U743,U744" /idTUdmin="U743" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" downshifts 969571 /Source="Nicolas_upshifts" /id="D493" /incds=0 /nref=53 /ntot=190 /MaxReadThrough="3.64545" /MaxDrop="6.08377" /score="26.3320532" /energy="-9.8" /TU="U744" /idTUdmin="U743" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" upshifts complement(969605) /Source="Nicolas_upshifts" /id="U745" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=1640 /SigmaFactorBS="acattttcatttttaggAGCAACCAAAacgcctgtgctCCGT CTAATGAAAAAAacccgttccaatgaacgggttttctctaaaaattagaatcttttcg c" /listShort="S327, phoA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(969612..969627) /Source="Nicolas_upshift_promotors" /id="U745" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=1640 /SigmaFactorBS="acattttcatttttaggAGCAACCAAAacgcctgtgctCCGT CTAATGAAAAAAacccgttccaatgaacgggttttctctaaaaattagaatcttttcg c" /listShort="S327, phoA" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 969617 /Source="Nicolas_upshifts" /id="D494" /incds=0 /nref=1 /ntot=47 /MaxReadThrough="2.99" /MaxDrop="3.76174" /score="26.3320532" /energy="-9.8" /TU="U744" /idTUdmin="U743" /TUdmin=44 /isTUend="FALSE" /label="downshifts" promotor_-35 complement(969639..969648) /Source="Nicolas_upshift_promotors" /id="U745" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=1640 /SigmaFactorBS="acattttcatttttaggAGCAACCAAAacgcctgtgctCCGT CTAATGAAAAAAacccgttccaatgaacgggttttctctaaaaattagaatcttttcg c" /listShort="S327, phoA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(969650..970525) /gene="citR" /locus_tag="BSU_09430" /old_locus_tag="BSU09430" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8045899, 10869065" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045899, 10869065; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator CitR (LysR family)" /protein_id="NP_388824.2" /db_xref="EnsemblGenomes-Gn:BSU09430" /db_xref="EnsemblGenomes-Tr:CAB12782" /db_xref="GOA:P39127" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10853" /db_xref="UniProtKB/Swiss-Prot:P39127" /translation="MDFKWLHTFVTAAKYENFRKTAETLFLSQPTVTVHIKQLEKEIS CKLFERKGRQIQLTDEGRAYLPYALRLLDDYENSMAELHRVRQGYSQTLQLAVSPLIA DTVLPSVMKRYTAMNTETEMAVTIFESAEIASLIKAGEADIGLSCLKVQSSSLSCHCL YKDPVVLVAPPDKRFIEDNEIDAKEVLEQYLLLTHNHPDYWDDLLRQVRMTFPFVRTM KVTQTHITKRFIKEGLGVSFLPLSTVKRELAEKQMIRIPYQSVQLPYAGAYAIALYEN KKEKKFLDFLSHFHF*" /label="citR CDS" gene complement(969650..970525) /gene="citR" /locus_tag="BSU_09430" /old_locus_tag="BSU09430" /label="citR gene" promotor_-35 970578..970579 /Source="Nicolas_upshift_promotors" /id="U747" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.424575424575425" /psig="0.995004995004995" /xcortree=3081 /SigmaFactorBS="atatttttaattaattccctttaaaatattgaTTatttttta aatattatATTTACTATAATAACAGAAAaggatagggggaatacaaatggtacattac g" /listShort="citA, yhdF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(970591..970610) /Source="Nicolas_upshift_promotors" /id="U746" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.387612387612388" /psig="0.992007992007992" /xcortree=1894 /SigmaFactorBS="tccctttaatccgtaatgtaccatttgTATTCCccctatcct tttctGTTATTATAGTAAATATAATatttaaaaaataatcaatattttaaagggaatt a" /listShort="citR, S327" /listLong="phoA" /label="promotor_-10" promotor_-10 970596..970615 /Source="Nicolas_upshift_promotors" /id="U747" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.424575424575425" /psig="0.995004995004995" /xcortree=3081 /SigmaFactorBS="atatttttaattaattccctttaaaatattgaTTatttttta aatattatATTTACTATAATAACAGAAAaggatagggggaatacaaatggtacattac g" /listShort="citA, yhdF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(970597) /Source="Nicolas_upshifts" /id="U746" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.387612387612388" /psig="0.992007992007992" /xcortree=1894 /SigmaFactorBS="tccctttaatccgtaatgtaccatttgTATTCCccctatcct tttctGTTATTATAGTAAATATAATatttaaaaaataatcaatattttaaagggaatt a" /listShort="citR, S327" /listLong="phoA" /label="upshifts" upshifts 970606 /Source="Nicolas_upshifts" /id="U747" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.424575424575425" /psig="0.995004995004995" /xcortree=3081 /SigmaFactorBS="atatttttaattaattccctttaaaatattgaTTatttttta aatattatATTTACTATAATAACAGAAAaggatagggggaatacaaatggtacattac g" /listShort="citA, yhdF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(970625..970630) /Source="Nicolas_upshift_promotors" /id="U746" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.387612387612388" /psig="0.992007992007992" /xcortree=1894 /SigmaFactorBS="tccctttaatccgtaatgtaccatttgTATTCCccctatcct tttctGTTATTATAGTAAATATAATatttaaaaaataatcaatattttaaagggaatt a" /listShort="citR, S327" /listLong="phoA" /label="promotor_-35" CDS 970634..971734 /gene="citA" /locus_tag="BSU_09440" /old_locus_tag="BSU09440" /EC_number="2.3.3.16" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:4211224, 8045898, 8045899" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4211224, 8045898, 8045899; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="citrate synthase I" /protein_id="NP_388825.2" /db_xref="EnsemblGenomes-Gn:BSU09440" /db_xref="EnsemblGenomes-Tr:CAB12783" /db_xref="GOA:P39119" /db_xref="InterPro:IPR002020" /db_xref="InterPro:IPR016142" /db_xref="InterPro:IPR016143" /db_xref="InterPro:IPR019810" /db_xref="InterPro:IPR024176" /db_xref="InterPro:IPR036969" /db_xref="PDB:2C6X" /db_xref="SubtiList:BG10854" /db_xref="UniProtKB/Swiss-Prot:P39119" /translation="MVHYGLKGITCVETSISHIDGEKGRLIYRGHHAKDIALNHSFEE AAYLILFGKLPSTEELQVFKDKLAAERNLPEHIERLIQSLPNNMDDMSVLRTVVSALG ENTYTFHPKTEEAIRLIAITPSIIAYRKRWTRGEQAIAPSSQYGHVENYYYMLTGEQP SEAKKKALETYMILATEHGMNASTFSARVTLSTESDLVSAVTAALGTMKGPLHGGAPS AVTKMLEDIGEKEHAEAYLKEKLEKGERLMGFGHRVYKTKDPRAEALRQKAEEVAGND RDLDLALHVEAEAIRLLEIYKPGRKLYTNVEFYAAAVMRAIDFDDELFTPTFSASRMV GWCAHVLEQAENNMIFRPSAQYTGAIPEEVLS*" /label="citA CDS" gene 970634..971734 /gene="citA" /locus_tag="BSU_09440" /old_locus_tag="BSU09440" /label="citA gene" promotor_-35 971745..971751 /Source="Nicolas_upshift_promotors" /id="U748" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=256 /SigmaFactorBS="attcccgaggaagttctttcataacatattttggCGTTTATt catttctgtcgtgTGGTAACGTTCAGTATCAAccacatgtctaggagtgatgaatgtg a" /listShort="yhdF, S329, ctrA, yhdH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 971766..971784 /Source="Nicolas_upshift_promotors" /id="U748" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=256 /SigmaFactorBS="attcccgaggaagttctttcataacatattttggCGTTTATt catttctgtcgtgTGGTAACGTTCAGTATCAAccacatgtctaggagtgatgaatgtg a" /listShort="yhdF, S329, ctrA, yhdH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 971771 /Source="Nicolas_upshifts" /id="U748" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=256 /SigmaFactorBS="attcccgaggaagttctttcataacatattttggCGTTTATt catttctgtcgtgTGGTAACGTTCAGTATCAAccacatgtctaggagtgatgaatgtg a" /listShort="yhdF, S329, ctrA, yhdH" /GFF_Attribute="listLong" /label="upshifts" CDS 971808..972677 /gene="yhdF" /locus_tag="BSU_09450" /old_locus_tag="BSU09450" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10482513, 18643936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD(P)-dependent dehydrogenase" /protein_id="NP_388826.1" /db_xref="EnsemblGenomes-Gn:BSU09450" /db_xref="EnsemblGenomes-Tr:CAB12784" /db_xref="GOA:O07575" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13012" /db_xref="UniProtKB/Swiss-Prot:O07575" /translation="MNPMDRQTEGQEPQHQDRQPGIESKMNPLPLSEDEDYRGSGKLK GKVAIITGGDSGIGRAAAIAFAKEGADISILYLDEHSDAEETRKRIEKENVRCLLIPG DVGDENHCEQAVQQTVDHFGKLDILVNNAAEQHPQDSILNISTEQLEKTFRTNIFSMF HMTKKALPHLQEGCAIINTTSITAYEGDTALIDYSSTKGAIVSFTRSMAKSLADKGIR VNAVAPGPIWTPLIPATFPEEKVKQHGLDTPMGRPGQPVEHAGAYVLLASDESSYMTG QTIHVNGGRFIST*" /label="yhdF CDS" gene 971808..972677 /gene="yhdF" /locus_tag="BSU_09450" /old_locus_tag="BSU09450" /label="yhdF gene" downshifts 972685 /Source="Nicolas_upshifts" /id="D495" /incds=0 /nref=27 /ntot=130 /MaxReadThrough="8.65426" /MaxDrop="6.48064" /score="18.1511963" /energy="-8.2" /TU="U748" /idTUdmin="U747" /TUdmin=9 /isTUend="TRUE" /label="downshifts" promotor_-35 972762..972765 /Source="Nicolas_upshift_promotors" /id="U749" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.597402597402597" /psig="0.998001998001998" /xcortree=2903 /SigmaFactorBS="tgaaaaatttcaaaataaaaaatttgtcgatttttctaacaa tttTGTTttcatttttgcaatTTTATATATAATATTGAGTAggagaaaggaatgattc g" /listShort="S329, ctrA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 972777 /Source="Nicolas_upshifts" /id="U749" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.597402597402597" /psig="0.998001998001998" /xcortree=2903 /SigmaFactorBS="tgaaaaatttcaaaataaaaaatttgtcgatttttctaacaa tttTGTTttcatttttgcaatTTTATATATAATATTGAGTAggagaaaggaatgattc g" /listShort="S329, ctrA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 972780..972799 /Source="Nicolas_upshift_promotors" /id="U749" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.597402597402597" /psig="0.998001998001998" /xcortree=2903 /SigmaFactorBS="tgaaaaatttcaaaataaaaaatttgtcgatttttctaacaa tttTGTTttcatttttgcaatTTTATATATAATATTGAGTAggagaaaggaatgattc g" /listShort="S329, ctrA" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature 972825..972844 /Source="Nicolas_upshift_promotors" /id="U750" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.509490509490509" /psig="0.522477522477522" /xcortree=652 /SigmaFactorBS="tttttgcaattttatatataatattgagtaggagaaaggaat gattcgcgaccagTACAAATATAGTAGAAAAAAaagaataatgaccattgttactcat g" /listShort="S329, ctrA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 972830..972926 /Source="Nicolas_S_feature" /locus_tag="new_1023253_1023349" /HighExp="Etha, T2.30H, T-0.40H, T2.0H, T1.30H, S1, GM-0.2, T3.0H, T-1.40H, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.27332800000000002" /TUshortSig="SigA, SigA, SigB" /TUshortPSig="0.522, 0.998, 0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S329" upshifts 972830 /Source="Nicolas_upshifts" /id="U750" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.509490509490509" /psig="0.522477522477522" /xcortree=652 /SigmaFactorBS="tttttgcaattttatatataatattgagtaggagaaaggaat gattcgcgaccagTACAAATATAGTAGAAAAAAaagaataatgaccattgttactcat g" /listShort="S329, ctrA" /GFF_Attribute="listLong" /label="upshifts" CDS 972927..974324 /gene="bcaP" /locus_tag="BSU_09460" /old_locus_tag="BSU09460" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16621821, 16850406, 21097623, 25645558" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16621821, 16850406, 21097623, 25645558; Product type t : transporter" /codon_start=1 /transl_table=11 /product="branched-chain amino acid transporter or methylthioribose-degradation metabolite exporter" /protein_id="NP_388827.1" /db_xref="EnsemblGenomes-Gn:BSU09460" /db_xref="EnsemblGenomes-Tr:CAB12785" /db_xref="GOA:O07576" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004758" /db_xref="SubtiList:BG13013" /db_xref="UniProtKB/Swiss-Prot:O07576" /translation="MKGSVFRKKSIQDLIAATSGEKSLKRELGAFDLTLLGIGAIIGT GIFVLTGTGAVTAGPGLTISFVVAALACLFAALSYAEFASSVPVSGSVYTFTYATLGE LMAFIIGWDLILEYMLAVSAVSVGWSGYFQSFLSGLGIHLPVALTAAPGAVKGTFTLF NLPAFVIVMAITYLLYLGIKESKRVNNIMVILKILVVLLFIAVAAVYVKPHNWQPFMP MGFGGVFSAAALVFFAFIGFDAVSSAAEETKNPAKDLPKGIIFSLLVCTILYVTVSAI MTGVIPFAQFAGVDHPVSLVLQSAGQNWVAGIIDIGAVLGMTTVMLVMLYGQTRVMFA MSRDGLVPGSLSKVHPKHKTPYVATWFFGTMSALLGSLVPLDELAKLVNIGTLSAFVL ISVAVIVLRKKQPDLPRAFKCPGVPVIPGLAILFCLFLILNLGWVTIVRFLVWLLIGL VIYFLYSRKHSKLNQ*" /label="bcaP CDS" gene 972927..974324 /gene="bcaP" /locus_tag="BSU_09460" /old_locus_tag="BSU09460" /label="bcaP gene" downshifts 974304 /Source="Nicolas_upshifts" /id="D496" /incds=0 /nref=116 /ntot=188 /MaxReadThrough="3.41176" /MaxDrop="5.29633" /score="5.08283681" /energy="-12.3" /TU="U748,U749" /idTUdmin="U750" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 974385..974389 /Source="Nicolas_upshift_promotors" /id="U751" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.914085914085914" /psig=1 /xcortree=2512 /SigmaFactorBS="ggccgcctcttttctgttcttggcaaatgaatcTATAGaaat gaagacaaaaaTAAGAGATAATATAGGCTGGaaaggaagtgacgtttattgtctgagc a" /listShort="yhdH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 974405..974424 /Source="Nicolas_upshift_promotors" /id="U751" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.914085914085914" /psig=1 /xcortree=2512 /SigmaFactorBS="ggccgcctcttttctgttcttggcaaatgaatcTATAGaaat gaagacaaaaaTAAGAGATAATATAGGCTGGaaaggaagtgacgtttattgtctgagc a" /listShort="yhdH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 974412 /Source="Nicolas_upshifts" /id="U751" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.914085914085914" /psig=1 /xcortree=2512 /SigmaFactorBS="ggccgcctcttttctgttcttggcaaatgaatcTATAGaaat gaagacaaaaaTAAGAGATAATATAGGCTGGaaaggaagtgacgtttattgtctgagc a" /listShort="yhdH" /GFF_Attribute="listLong" /label="upshifts" CDS 974442..975797 /gene="yhdH" /locus_tag="BSU_09470" /old_locus_tag="BSU09470" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 17114254; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sodium-dependent transporter" /protein_id="NP_388828.1" /db_xref="EnsemblGenomes-Gn:BSU09470" /db_xref="EnsemblGenomes-Tr:CAB12786" /db_xref="GOA:O07577" /db_xref="InterPro:IPR000175" /db_xref="SubtiList:BG13014" /db_xref="UniProtKB/Swiss-Prot:O07577" /translation="MSEQKPVQWASKIGFVMAAAGSAIGLGAIWKFPYVAGTNGGGAF FLIFVLFTILLGYPLLVGEFIFGRRNQTNAIDAYKKEAPRSAWFLTGWIGVAACFLVL SFYSVIGGWILLYIVKTASGSLSGLSQAQYGALFASIIQNPVQTLAAQLVFMALTVLV VARGVQKGIERVSAVMMPILFLLFILLVLRSLTLNGAMEGVKFLLVPHFGDLTPESIL FALGQAFFTLTLGVSVMVTYSSYLPKTQNIPRSAASIVLMNIIVTLLAGLAIFPAVFS FGFQPNEGPTLLFTVLPAVFEQLPFGTLFFIGFLVAFLFAALTSAFSMVEIIVATIGK GDEKKRKKLSWTSGLLIFLVGIPCCLSYGVLSDVHLFGKTFFDIADFTVSNVLMPSGA LLISLFIPLKISKSELLAEMRNGSNAGKAFFYTWFYLLRFIVPLAIIIVFLNLIGILS F*" /label="yhdH CDS" gene 974442..975797 /gene="yhdH" /locus_tag="BSU_09470" /old_locus_tag="BSU09470" /label="yhdH gene" downshifts 975778 /Source="Nicolas_upshifts" /id="D497" /incds=0 /nref=184 /ntot=244 /MaxReadThrough="1.73756" /MaxDrop="6.09379" /score="40.1809389" /energy="-14.8" /TU="NA" /idTUdmin="U751" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(975832..977241) /gene="yhdI" /locus_tag="BSU_09480" /old_locus_tag="BSU09480" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15223311; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative PLP-dependent transcriptional regulator" /protein_id="NP_388829.1" /db_xref="EnsemblGenomes-Gn:BSU09480" /db_xref="EnsemblGenomes-Tr:CAB12787" /db_xref="GOA:O07578" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13015" /db_xref="UniProtKB/Swiss-Prot:O07578" /translation="MDITPFLDKKSKTPLYEQLYTFFKQEISHARITKGTRLPSKRRL SSLLDVSTATIERAYEQLTAEGYVKSKPKIGWFAAEVEPGFPTAPDHFQQSVQPGLHQ KNAPAIDFHQGSVDPTLFPFNAWRKSIVKSLDRYSGSFHTSGDPQGEYELRHMIARFV RLSRGVNCEPGQIIIGAGTTVLLQNLCLSLKPGTKIGFEEPGFHRSRRMFEANHMDVT PICSDAEGVLPDELYRQNPYLMYTTPSHQFPIGTIMTITRRQELLAWAAETNSFIIED DYDGEFRYSGHPIPSLQGLDPNGRVIYLGTFSKSLLPSLRLSFMIVPPELMEPIQNNV QLMKQTVSAHSQLALADFIETGEWQKHINRMRSLYRKKHAVLLEAIRSELGNTVEILG KNSGLHILLRLLFPASEEEAIQAAADHGVTLYPVSPSYIEQTPFTSVLIGYGGLSEED IRLGIQKLKTAWAPLISSY*" /label="yhdI CDS" gene complement(975832..977241) /gene="yhdI" /locus_tag="BSU_09480" /old_locus_tag="BSU09480" /label="yhdI gene" promotor_-35 977290..977293 /Source="Nicolas_upshift_promotors" /id="U752" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.52047952047952" /psig="0.996003996003996" /xcortree=459 /SigmaFactorBS="tcctttgtagctggcatggtcattttttctgatattggctAT TTggcaaatgccatttATTAGCTATGATCATTGTAAcgaaaggaaaggggattgagaa g" /listShort="yhdJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 977308..977327 /Source="Nicolas_upshift_promotors" /id="U752" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.52047952047952" /psig="0.996003996003996" /xcortree=459 /SigmaFactorBS="tcctttgtagctggcatggtcattttttctgatattggctAT TTggcaaatgccatttATTAGCTATGATCATTGTAAcgaaaggaaaggggattgagaa g" /listShort="yhdJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 977310 /Source="Nicolas_upshifts" /id="U752" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.52047952047952" /psig="0.996003996003996" /xcortree=459 /SigmaFactorBS="tcctttgtagctggcatggtcattttttctgatattggctAT TTggcaaatgccatttATTAGCTATGATCATTGTAAcgaaaggaaaggggattgagaa g" /listShort="yhdJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(977312..977331) /Source="Nicolas_upshift_promotors" /id="U753" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=2744 /SigmaFactorBS="cttctttcgaggttaattgtttcatatggatcaTCTTCtcaa tcccctttcctTTCGTTACAATGATCATAGCtaataaatggcatttgccaaatagcca a" /listShort="yhdI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(977324) /Source="Nicolas_upshifts" /id="U753" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=2744 /SigmaFactorBS="cttctttcgaggttaattgtttcatatggatcaTCTTCtcaa tcccctttcctTTCGTTACAATGATCATAGCtaataaatggcatttgccaaatagcca a" /listShort="yhdI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(977347..977351) /Source="Nicolas_upshift_promotors" /id="U753" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=2744 /SigmaFactorBS="cttctttcgaggttaattgtttcatatggatcaTCTTCtcaa tcccctttcctTTCGTTACAATGATCATAGCtaataaatggcatttgccaaatagcca a" /listShort="yhdI" /GFF_Attribute="listLong" /label="promotor_-35" CDS 977351..977779 /gene="yhdJ" /locus_tag="BSU_09490" /old_locus_tag="BSU09490" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12793527; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_388830.1" /db_xref="EnsemblGenomes-Gn:BSU09490" /db_xref="EnsemblGenomes-Tr:CAB12788" /db_xref="GOA:O07579" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13016" /db_xref="UniProtKB/Swiss-Prot:O07579" /translation="MIHMKQLTSKEEWAESYPIMSELRTELDIETYLQRLEACVQKES YMLFALYENTAIRALCGALPRVSIHKGEHLWIADLVTTAPCRSKGYGKMLLDYASDWA RKAGLGFVSLSSGLQRKDAHRFYTDKMGFTIESYLFRKPV*" /label="yhdJ CDS" gene 977351..977779 /gene="yhdJ" /locus_tag="BSU_09490" /old_locus_tag="BSU09490" /label="yhdJ gene" downshifts 977758 /Source="Nicolas_upshifts" /id="D498" /incds=0 /nref=46 /ntot=213 /MaxReadThrough="1.42962" /MaxDrop="4.77191" /score="24.6412105" /energy="-12.1" /TU="NA" /idTUdmin="U752" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(977810..978100) /gene="asiMB" /locus_tag="BSU_09500" /old_locus_tag="BSU09500" /experiment="publication(s) with functional evidences, PMID:10216858" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10216858; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of the activity of sigma-M" /protein_id="NP_388831.1" /db_xref="EnsemblGenomes-Gn:BSU09500" /db_xref="EnsemblGenomes-Tr:CAB12789" /db_xref="GOA:O07580" /db_xref="InterPro:IPR020496" /db_xref="SubtiList:BG13017" /db_xref="UniProtKB/Swiss-Prot:O07580" /translation="MELVRIFKEHNVFGWISVGTAVLSLLLLNLAIISNVTFYSYQML PFAMAAVPFGVVELFIKRGRTGPGLLGVILNLFVIICVYTIVSVDTNLQFGF*" /label="asiMB CDS" gene complement(977810..978100) /gene="asiMB" /locus_tag="BSU_09500" /old_locus_tag="BSU09500" /label="asiMB gene" downshifts complement(977834) /Source="Nicolas_upshifts" /id="D499" /incds=0 /nref=44 /ntot=229 /MaxReadThrough="2.66153" /MaxDrop="4.72865" /score="26.7359231" /energy="-11.1" /TU="NA" /idTUdmin="U754" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(978088..979164) /gene="asiMA" /locus_tag="BSU_09510" /old_locus_tag="BSU09510" /experiment="publication(s) with functional evidences, PMID:10216858" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10216858; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of the activity of sigma-M" /protein_id="NP_388832.1" /db_xref="EnsemblGenomes-Gn:BSU09510" /db_xref="EnsemblGenomes-Tr:CAB12790" /db_xref="GOA:O07581" /db_xref="InterPro:IPR025672" /db_xref="InterPro:IPR029101" /db_xref="SubtiList:BG13018" /db_xref="UniProtKB/Swiss-Prot:O07581" /translation="MMNEEFKKRFDQYKNGEMSDQEMTAFEEELEKLEVYQELIDSEL EDDNDWDLSISPEKQKAILAYGKRKSYLRISVLAVISTLMILPLCTLGSYLYYGMGGK HSTGNEFMETAAVTVALTMPNVLVDTSGLKSQVKLFGMNTEFPLQKQIGTKTAAVGNE RVEMFYNKVKAPAVNYYDLEVNKTGHYFTHPSNKSEQTTAKAEKTLSTLPEGTVSEVY LSYDRAYPTKDVYNKFKGYDVSFLWNAIETEKNTNKTASTEPLGYPGKDSKFLAALNT KGKSNGDQFINALKFMSKHEKWAQVISKRKDLNVDNRLDYVEKNGVNVYGSVVTGPTK EIQRMLKNKSVKSANVGEVELWNW*" /label="asiMA CDS" gene complement(978088..979164) /gene="asiMA" /locus_tag="BSU_09510" /old_locus_tag="BSU09510" /label="asiMA gene" CDS complement(979154..979645) /gene="sigM" /locus_tag="BSU_09520" /old_locus_tag="BSU09520" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14651641, 14769884" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14651641, 14769884; Product type r: regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase ECF (extracytoplasmic function)-type sigma factor (sigma(M))" /protein_id="NP_388833.1" /db_xref="EnsemblGenomes-Gn:BSU09520" /db_xref="EnsemblGenomes-Tr:CAB12791" /db_xref="GOA:O07582" /db_xref="InterPro:IPR000838" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR014296" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG13019" /db_xref="UniProtKB/Swiss-Prot:O07582" /translation="MTIDEIYQMYMNDVYRFLLSMTKDKHLAEDLLQETFMRAYIHIH SYDHSKVKPWLFQVARNAFIDYVRKHKKEVTISDDLIGSLFQNAVQSPAHQVEIKEVL TGYMSELPDNYREALTLYYLKELNYKEASHIMNISEANFKSVLFRARQRLKALYNRGV NDE*" /label="sigM CDS" gene complement(979154..979645) /gene="sigM" /locus_tag="BSU_09520" /old_locus_tag="BSU09520" /label="sigM gene" S_feature complement(979646..979748) /Source="Nicolas_S_feature" /locus_tag="new_1030069_1030171_c" /HighExp="Cold, LBGstat, H2O2, G180, Paraq, Oxctl, G135, HPh, dia15, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S330" promotor_-10 complement(979737..979756) /Source="Nicolas_upshift_promotors" /id="U754" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.826173826173826" /psig=1 /xcortree=2579 /SigmaFactorBS="ccctctggaaaaaatgttaaacctttctccgcactATCTttt gcggccatttTTGGGTACTATATAGTAATGgtgtttgattaggtataaaaaagccgtt t" /listShort="S330, sigM, yhdL, yhdK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(979748) /Source="Nicolas_upshifts" /id="U754" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.826173826173826" /psig=1 /xcortree=2579 /SigmaFactorBS="ccctctggaaaaaatgttaaacctttctccgcactATCTttt gcggccatttTTGGGTACTATATAGTAATGgtgtttgattaggtataaaaaagccgtt t" /listShort="S330, sigM, yhdL, yhdK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(979770..979773) /Source="Nicolas_upshift_promotors" /id="U754" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.826173826173826" /psig=1 /xcortree=2579 /SigmaFactorBS="ccctctggaaaaaatgttaaacctttctccgcactATCTttt gcggccatttTTGGGTACTATATAGTAATGgtgtttgattaggtataaaaaagccgtt t" /listShort="S330, sigM, yhdL, yhdK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 979786..979792 /Source="Nicolas_upshift_promotors" /id="U755" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=224 /SigmaFactorBS="tatatagtacccaaaaatggccgcaaaagatagtgcggagaa aGGTTTAAcattttttccagagGGGAAAAGATAGTGAAAAAgtgaaggagtggcacaa t" /listShort="yhdN, plsC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 979803 /Source="Nicolas_upshifts" /id="U755" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=224 /SigmaFactorBS="tatatagtacccaaaaatggccgcaaaagatagtgcggagaa aGGTTTAAcattttttccagagGGGAAAAGATAGTGAAAAAgtgaaggagtggcacaa t" /listShort="yhdN, plsC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 979807..979825 /Source="Nicolas_upshift_promotors" /id="U755" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=224 /SigmaFactorBS="tatatagtacccaaaaatggccgcaaaagatagtgcggagaa aGGTTTAAcattttttccagagGGGAAAAGATAGTGAAAAAgtgaaggagtggcacaa t" /listShort="yhdN, plsC" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(979836) /Source="Nicolas_upshifts" /id="D500" /incds=0 /nref=2 /ntot=13 /MaxReadThrough="2.13683" /MaxDrop="4.59517" /score="8.96845329" /energy="-10.2" /TU="NA" /idTUdmin="U757" /TUdmin=1804 /isTUend="FALSE" /label="downshifts" CDS 979842..980837 /gene="akrN" /locus_tag="BSU_09530" /old_locus_tag="BSU09530" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10220166, 15019785, 24330391" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10220166, 15019785, 24330391; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aldo/keto reductase specific for NADPH; protectsagainst methylglyoxal" /protein_id="NP_388834.1" /db_xref="EnsemblGenomes-Gn:BSU09530" /db_xref="EnsemblGenomes-Tr:CAB12792" /db_xref="GOA:P80874" /db_xref="InterPro:IPR018170" /db_xref="InterPro:IPR020471" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="PDB:1PZ1" /db_xref="SubtiList:BG13020" /db_xref="UniProtKB/Swiss-Prot:P80874" /translation="MEYTSIADTGIEASRIGLGTWAIGGTMWGGTDEKTSIETIRAAL DQGITLIDTAPAYGFGQSEEIVGKAIKEYGKRDQVILATKTALDWKNNQLFRHANRAR IVEEVENSLKRLQTDYIDLYQVHWPDPLVPIEETAEVMKELYDAGKIRAIGVSNFSIE QMDTFRAVAPLHTIQPPYNLFEREMEESVLPYAKDNKITTLLYGSLCRGLLTGKMTEE YTFEGDDLRNHDPKFQKPRFKEYLSAVNQLDKLAKTRYGKSVIHLAVRWILDQPGADI ALWGARKPGQLEALSEITGWTLNSEDQKDINTILENTISDPVGPEFMAPPTREEI*" /label="akrN CDS" gene 979842..980837 /gene="akrN" /locus_tag="BSU_09530" /old_locus_tag="BSU09530" /label="akrN gene" downshifts 980816 /Source="Nicolas_upshifts" /id="D501" /incds=0 /nref=59 /ntot=160 /MaxReadThrough="6.85446" /MaxDrop="4.90106" /score="10.4379759" /energy="-11.8" /TU="U755" /idTUdmin="U756" /TUdmin="-770" /isTUend="FALSE" /label="downshifts" promotor_-35 980899..980902 /Source="Nicolas_upshift_promotors" /id="U756" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.537462537462537" /psig=1 /xcortree=2186 /SigmaFactorBS="ctttttggcgtttaaacgagagaaatcttaaaaattaGTACc aggtaataaaaaaTATTGTTATAATAGATGACAgaaagaatcattgattacgacaaag g" /listShort="plsC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 980917..980936 /Source="Nicolas_upshift_promotors" /id="U756" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.537462537462537" /psig=1 /xcortree=2186 /SigmaFactorBS="ctttttggcgtttaaacgagagaaatcttaaaaattaGTACc aggtaataaaaaaTATTGTTATAATAGATGACAgaaagaatcattgattacgacaaag g" /listShort="plsC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 980922 /Source="Nicolas_upshifts" /id="U756" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.537462537462537" /psig=1 /xcortree=2186 /SigmaFactorBS="ctttttggcgtttaaacgagagaaatcttaaaaattaGTACc aggtaataaaaaaTATTGTTATAATAGATGACAgaaagaatcattgattacgacaaag g" /listShort="plsC" /GFF_Attribute="listLong" /label="upshifts" CDS 980972..981571 /gene="plsC" /locus_tag="BSU_09540" /old_locus_tag="BSU09540" /EC_number="2.3.1.51" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 1557036, 17557823" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 1557036, 17557823; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="1-acylglycerol-phosphate (1-acyl-G3P) acyltransferase" /protein_id="NP_388835.1" /db_xref="EnsemblGenomes-Gn:BSU09540" /db_xref="EnsemblGenomes-Tr:CAB12793" /db_xref="GOA:O07584" /db_xref="InterPro:IPR002123" /db_xref="InterPro:IPR004552" /db_xref="SubtiList:BG13021" /db_xref="UniProtKB/Swiss-Prot:O07584" /translation="MYKFCANALKVILSLRGGVKVYNKENLPADSGFVIACTHSGWVD VITLGVGILPYQIHYMAKKELFQNKWIGSFLKKIHAFPVDRENPGPSSIKTPIKLLKE GEIVGIFPSGTRTSEDVPLKRGAVTIAQMGKAPLVPAAYQGPSSGKELFKKGKMKLII GEPLHQADFAHLPSKERLAAMTEALNQRIKELENKLDQL*" /label="plsC CDS" gene 980972..981571 /gene="plsC" /locus_tag="BSU_09540" /old_locus_tag="BSU09540" /label="plsC gene" downshifts 981586 /Source="Nicolas_upshifts" /id="D502" /incds=0 /nref=189 /ntot=245 /MaxReadThrough="6.36101" /MaxDrop="7.07164" /score="-7.3088084" /energy="-6.1" /TU="U755" /idTUdmin="U756" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 981631..983585 /Source="Nicolas_S_feature" /locus_tag="new_1032054_1034008" /HighExp="Cold, C30, S8, T-4.40H, Sw, Fru, S0, S7, HPh, G135" /AntisenseName="yhdP" /AntisenseCor="-0.46228251493795502" /AntisenseRegPval="-14.9" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S331" CDS complement(981640..982974) /gene="yhdP" /locus_tag="BSU_09550" /old_locus_tag="BSU09550" /function="16.1: Circulate" /function="16.12: Sense" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106, 25182490; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative magnesium efflux pump" /protein_id="NP_388836.1" /db_xref="EnsemblGenomes-Gn:BSU09550" /db_xref="EnsemblGenomes-Tr:CAB12794" /db_xref="GOA:O07585" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR002550" /db_xref="InterPro:IPR005170" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG13022" /db_xref="UniProtKB/Swiss-Prot:O07585" /translation="MDIVNLILVAVLIALTAFFVASEFAIIRIRGSRIDQLIAEGNKA AIAVKKVTTHLDEYLSACQLGITLTSIGLGVLGESTIERLLHPLFVQMNVPGSLSHVI SFIFAYAIITFLHVVVGELAPKTVAIQKAEAVSMLFAKPLIWFYRIAFPFIWLLNNSA RLLTKAFGLETVSENELAHSEEELRIILSESYKSGEINQSEFKYVNKIFEFDDRLAKE IMIPRTEIVSLPHDIKISEMMDIIQIEKYTRYPVEEGDKDNIIGVINIKEVLTACISG EVSVDSTISQFVNPIIHVIESAPIQDLLVKMQKERVHMAILSDEYGGTAGLVTVEDII EEIVGEIRDEFDIDEISEIRKIGEGHYILDGKVLIDQVNDLLGIHLENEEVDTIGGWF LTQKYDVEKDDSIIEEGCEFIINEIDGHHVAYIEVKKLQEEELLETANQQEA*" /label="yhdP CDS" gene complement(981640..982974) /gene="yhdP" /locus_tag="BSU_09550" /old_locus_tag="BSU09550" /label="yhdP gene" downshifts complement(981659) /Source="Nicolas_upshifts" /id="D503" /incds=0 /nref=284 /ntot=315 /MaxReadThrough="1.96991" /MaxDrop="7.22379" /score="11.1466394" /energy="-9.1" /TU="NA" /idTUdmin="U757" /TUdmin="-19" /isTUend="TRUE" /label="downshifts" CDS complement(983035..983466) /gene="cueR" /locus_tag="BSU_09560" /old_locus_tag="BSU09560" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14663075, 18048925" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14663075, 18048925; Product type r: regulator" /codon_start=1 /transl_table=11 /product="indirect copper efflux transcriptional regulator" /protein_id="NP_388837.1" /db_xref="EnsemblGenomes-Gn:BSU09560" /db_xref="EnsemblGenomes-Tr:CAB12795" /db_xref="GOA:O07586" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="SubtiList:BG13023" /db_xref="UniProtKB/Swiss-Prot:O07586" /translation="MVGRDIDGAETYRISELAALAGVTKRTVDYYTNLGLLTPARSCS NYRYYDENALKRLIFIVDCKKQRLALSDIKDRLENQFPSSAKLDDEIGNLALEIDHMN QNISGILHRFERLKPEDRDKLKSKLPPEKLAVFQSFMLLLS*" /label="cueR CDS" gene complement(983035..983466) /gene="cueR" /locus_tag="BSU_09560" /old_locus_tag="BSU09560" /label="cueR gene" promotor_-10 complement(983478..983497) /Source="Nicolas_upshift_promotors" /id="U757" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.410589410589411" /psig="0.965034965034965" /xcortree=2994 /SigmaFactorBS="cttccaattccggtctaaaaaaaacaataaACTTGTGcaaga caccgttcaTATATTAAACTATTCTCATAactataacgtgatggttgggagggatata g" /listShort="cueR, yhdP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(983488) /Source="Nicolas_upshifts" /id="U757" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.410589410589411" /psig="0.965034965034965" /xcortree=2994 /SigmaFactorBS="cttccaattccggtctaaaaaaaacaataaACTTGTGcaaga caccgttcaTATATTAAACTATTCTCATAactataacgtgatggttgggagggatata g" /listShort="cueR, yhdP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(983512..983518) /Source="Nicolas_upshift_promotors" /id="U757" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.410589410589411" /psig="0.965034965034965" /xcortree=2994 /SigmaFactorBS="cttccaattccggtctaaaaaaaacaataaACTTGTGcaaga caccgttcaTATATTAAACTATTCTCATAactataacgtgatggttgggagggatata g" /listShort="cueR, yhdP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_no_box complement(983514..983614) /Source="Nicolas_upshift_promotors" /id="U758" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.708291708291708" /psig="0.006993006993007" /xcortree=284 /SigmaFactorBS="tccgcatataaaaatttgaaaattctatcttcctatgttact tcaatcagatgatgaattccacaacttccaattccggtctaaaaaaaacaataaactt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-35 983549..983556 /Source="Nicolas_upshift_promotors" /id="U759" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.616383616383616" /psig="0.996003996003996" /xcortree=3066 /SigmaFactorBS="ttttttagaccggaattggaagTTGTGGAAttcatcatctga tTGAAGTAACATAGGAAGATAgaattttcaaatttttatatgcggaagggacagatga a" /listShort="yhdR, S332" /listLong="S333, yhdT" /label="promotor_-35" upshifts complement(983554) /Source="Nicolas_upshifts" /id="U758" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.708291708291708" /psig="0.006993006993007" /xcortree=284 /SigmaFactorBS="tccgcatataaaaatttgaaaattctatcttcctatgttact tcaatcagatgatgaattccacaacttccaattccggtctaaaaaaaacaataaactt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 983570..983589 /Source="Nicolas_upshift_promotors" /id="U759" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.616383616383616" /psig="0.996003996003996" /xcortree=3066 /SigmaFactorBS="ttttttagaccggaattggaagTTGTGGAAttcatcatctga tTGAAGTAACATAGGAAGATAgaattttcaaatttttatatgcggaagggacagatga a" /listShort="yhdR, S332" /listLong="S333, yhdT" /label="promotor_-10" upshifts 983587 /Source="Nicolas_upshifts" /id="U759" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.616383616383616" /psig="0.996003996003996" /xcortree=3066 /SigmaFactorBS="ttttttagaccggaattggaagTTGTGGAAttcatcatctga tTGAAGTAACATAGGAAGATAgaattttcaaatttttatatgcggaagggacagatga a" /listShort="yhdR, S332" /listLong="S333, yhdT" /label="upshifts" CDS 983623..984804 /gene="yhdR" /locus_tag="BSU_09570" /old_locus_tag="BSU09570" /EC_number="2.6.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12670965, 15103638; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aspartate aminotransferase" /protein_id="NP_388838.1" /db_xref="EnsemblGenomes-Gn:BSU09570" /db_xref="EnsemblGenomes-Tr:CAB12796" /db_xref="GOA:O07587" /db_xref="InterPro:IPR004838" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG13024" /db_xref="UniProtKB/Swiss-Prot:O07587" /translation="MKLAGLSREVEENLNKGSWIRKLFDEGARLKKEFGEDQVFDFSL GNPIVEPPEAFKRALIEEAEKGSHGYIQNQGLLAAREKVAQFLGSRFEADFSAERIVM TVGAGGALNVALKSIVNPGEEVIILAPYFAEYKLYIENYGGKAVSCPLTSRFEIDIEA VRQSITPQTKGLILNTPHNPTGTVLSQKNIDDLGALLKEIEEKSGQTIYVLFDEPYSQ LIYDEELANPFQSYHRVILASSFSKDLGIAGERLGYIGLDSRMPDADLLINAFVYCNR TLGFVNAPVMMQRAVARMDDLRVDASAYKERRDLMVDILKEAGFEFEMPKGGFFVFPK SPIEDEVAFCVHAAQKYKLLIVPSSGFGMSGHFRLSFSVPIEQIKNSRDIFISLYKDF A*" /label="yhdR CDS" gene 983623..984804 /gene="yhdR" /locus_tag="BSU_09570" /old_locus_tag="BSU09570" /label="yhdR gene" downshifts 984789 /Source="Nicolas_upshifts" /id="D504" /incds=0 /nref=12 /ntot=180 /MaxReadThrough="2.81766" /MaxDrop="3.37889" /score="-5.8634451" /energy="-9.1" /TU="U759" /idTUdmin="U759" /TUdmin="-163" /isTUend="FALSE" /label="downshifts" S_feature 984834..984972 /Source="Nicolas_S_feature" /locus_tag="new_1035257_1035395" /HighExp="Etha, S1, BMM, S2, Cold, MG 45, MG 25, C90, T-5.40H, MG 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S332" misc_feature 984968..984987 /Source="Nicolas_upshift_promotors" /id="U760" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.771228771228771" /psig="0.999000999001" /xcortree=460 /SigmaFactorBS="aaggctttcttcatgataaaagtctaaaaattaaaaatcatt tttggaatgagtTGTGTTACAATAAAATATACaatttataatcaaactttgacttttg g" /listShort="S333, yhdT" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 984974..985130 /Source="Nicolas_S_feature" /locus_tag="new_1035397_1035553" /HighExp="M9-stat, B60, T4.0H, T3.0H, LoTm, S5, T5.0H, S4, T2.30H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigA" /TUlongPSig="0.996" /label="S333" upshifts 984974 /Source="Nicolas_upshifts" /id="U760" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.771228771228771" /psig="0.999000999001" /xcortree=460 /SigmaFactorBS="aaggctttcttcatgataaaagtctaaaaattaaaaatcatt tttggaatgagtTGTGTTACAATAAAATATACaatttataatcaaactttgacttttg g" /listShort="S333, yhdT" /GFF_Attribute="listLong" /label="upshifts" CDS 985131..986516 /gene="yhdT" /locus_tag="BSU_09590" /old_locus_tag="BSU09590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="NP_388840.1" /db_xref="EnsemblGenomes-Gn:BSU09590" /db_xref="EnsemblGenomes-Tr:CAB12798" /db_xref="GOA:O07589" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR002550" /db_xref="InterPro:IPR005170" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG13026" /db_xref="UniProtKB/Swiss-Prot:O07589" /translation="MDDIDSLILIGVLIALTAFFVASEFAIVRVRRSRIDQLITEGNK RAILARRVITDLDEYLSASQLGITLTSIGLGVLGEPAFERLLHPLFEPLGLPDSVSHA VSFAVAYGLITFLHVVVGELAPKTVAIQKAEQLTLLIAGPLRLFYLLLFPFIWILNGS ARLLCGMFGLKPASEHDGSHSEEELRMLLSESLKNGEINPSEYKYVNKIFEFDNRIAK EIMIPRKEMAAVSTEMTMAEMLEVMLKEKYTRWPVTDGDKDSVLGLVNTKHLFSDLLF MTEEERMKMTIHPYVRPVIEVIETIPVHDLLIKMQRERIHMAILSDEYGGTSGLVTTE DILEEIVGEIRDEFDEDEQPLIQKLGDGHYVMDGKVRIDQVNSLLGASIQEDVDTIGG LILKENIDIEAGESIRIGSYTIKVLKMDGRLIKQIDIKEEAGNTTGITAHHKLPLPEP VMLNSATLSEK*" /label="yhdT CDS" gene 985131..986516 /gene="yhdT" /locus_tag="BSU_09590" /old_locus_tag="BSU09590" /label="yhdT gene" downshifts 986406 /Source="Nicolas_upshifts" /id="D505" /incds=1 /nref=120 /ntot=240 /MaxReadThrough="5.11037" /MaxDrop="3.79021" /score="19.6985636" /energy="-10.5" /TU="U760" /idTUdmin="U760" /TUdmin="-86" /isTUend="FALSE" /label="downshifts" downshifts 986492 /Source="Nicolas_upshifts" /id="D506" /incds=0 /nref=129 /ntot=245 /MaxReadThrough="1.68999" /MaxDrop="6.12682" /score="19.6985636" /energy="-10.5" /TU="NA" /idTUdmin="U760" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(986530..986886) /gene="crcBA" /locus_tag="BSU_09600" /old_locus_tag="BSU09600" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8844142, 12904550, 15849754, 16850406, 17196979, 22194412, 27824896; Product type t: transporter" /codon_start=1 /transl_table=11 /product="fluoride efflux channel component A" /protein_id="NP_388841.1" /db_xref="EnsemblGenomes-Gn:BSU09600" /db_xref="EnsemblGenomes-Tr:CAB12799" /db_xref="GOA:O07590" /db_xref="InterPro:IPR003691" /db_xref="SubtiList:BG13027" /db_xref="UniProtKB/Swiss-Prot:O07590" /translation="MTLAGIFIGGGLGAMLRFWLGNVITAKTKGLSLPIGILTVNILG ALGLGIFTGLHVANASVSLIIGTGFFGAFTTFSTFSVETIQLLMAKRVKESILYIVLT LCGSLFAFWCGWTITI*" /label="crcBA CDS" gene complement(986530..986886) /gene="crcBA" /locus_tag="BSU_09600" /old_locus_tag="BSU09600" /label="crcBA gene" CDS complement(986883..987278) /gene="crcBB" /locus_tag="BSU_09610" /old_locus_tag="BSU09610" /function="16.1: Circulate" /function="16.4: Excrete" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8844142, 12904550, 15849754, 16850406, 22194412, 27824896; Product type t : transporter" /codon_start=1 /transl_table=11 /product="subunit of fluoride efflux transporter" /protein_id="NP_388842.1" /db_xref="EnsemblGenomes-Gn:BSU09610" /db_xref="EnsemblGenomes-Tr:CAB12800" /db_xref="GOA:O07591" /db_xref="InterPro:IPR003691" /db_xref="SubtiList:BG13028" /db_xref="UniProtKB/Swiss-Prot:O07591" /translation="MKIYSAVFIGGALGACLRYGLNLWIHTGQFPAATWLENAAGSLL LGILTGFFMIGAKRPLLSAFLGTGFCGGFTTMSTFSKETVMLLQGQPSLALLYVAASL ISGIIFALIGVFVGRRIAGIQQRKGLQEK*" /label="crcBB CDS" gene complement(986883..987278) /gene="crcBB" /locus_tag="BSU_09610" /old_locus_tag="BSU09610" /label="crcBB gene" CDS complement(987265..987996) /gene="yhdW" /locus_tag="BSU_09620" /old_locus_tag="BSU09620" /EC_number="3.1.4.46" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8012593; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycerophosphodiester phosphodiesterase" /protein_id="NP_388843.1" /db_xref="EnsemblGenomes-Gn:BSU09620" /db_xref="EnsemblGenomes-Tr:CAB12801" /db_xref="GOA:O07592" /db_xref="InterPro:IPR004129" /db_xref="InterPro:IPR017946" /db_xref="InterPro:IPR030395" /db_xref="SubtiList:BG13029" /db_xref="UniProtKB/Swiss-Prot:O07592" /translation="MYIIAHRGASGYAPENTIAAFDLAVKMNADMIELDVQLTKDRQI VVIHDDRVDRTTNGSGFVKDFTLEELQKLDAGSWYGPAFQGERIPTLEAVLKRYHKKI GLLIELKGHPSQVGIEEEVGQLLGQFSFSINNIVQSFQFRSVQRFRELYPSIPTAVIT RPNFGMLSRNQMKAFRSFANYVNIKHTRLNRLMIGSINKNGLNIFAWTVNNQKTAAKL QAMGVDGIVTDYPDFIIKDGKHENI*" /label="yhdW CDS" gene complement(987265..987996) /gene="yhdW" /locus_tag="BSU_09620" /old_locus_tag="BSU09620" /label="yhdW gene" misc_feature complement(988021..988040) /Source="Nicolas_upshift_promotors" /id="U761" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.683316683316683" /psig="0.986013986013986" /xcortree=3010 /SigmaFactorBS="gcccggaccattccgatatggcagaaaaaattcaccagtttg tatcgcggtgcatatatggaTTTGATACAATAACAGAAATgcccatacgaggagctga c" /listShort="yhdW, yhdV, crcBA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(988042) /Source="Nicolas_upshifts" /id="U761" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.683316683316683" /psig="0.986013986013986" /xcortree=3010 /SigmaFactorBS="gcccggaccattccgatatggcagaaaaaattcaccagtttg tatcgcggtgcatatatggaTTTGATACAATAACAGAAATgcccatacgaggagctga c" /listShort="yhdW, yhdV, crcBA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 988089..988097 /Source="Nicolas_upshift_promotors" /id="U762" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.563436563436563" /psig="0.563436563436563" /xcortree=896 /SigmaFactorBS="atatgcaccgcgatacaaactggtgaattttttctgccatat cGGAATGGTCcgggctgaggaatGCGTATAACTAAAAAAagacactcagcgtatcaga a" /listShort="S334, yhdX" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 988106 /Source="Nicolas_upshifts" /id="U762" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.563436563436563" /psig="0.563436563436563" /xcortree=896 /SigmaFactorBS="atatgcaccgcgatacaaactggtgaattttttctgccatat cGGAATGGTCcgggctgaggaatGCGTATAACTAAAAAAagacactcagcgtatcaga a" /listShort="S334, yhdX" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 988111..988126 /Source="Nicolas_upshift_promotors" /id="U762" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.563436563436563" /psig="0.563436563436563" /xcortree=896 /SigmaFactorBS="atatgcaccgcgatacaaactggtgaattttttctgccatat cGGAATGGTCcgggctgaggaatGCGTATAACTAAAAAAagacactcagcgtatcaga a" /listShort="S334, yhdX" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 988120..988193 /Source="Nicolas_S_feature" /locus_tag="new_1038543_1038616" /HighExp="S5, S4, S6, S7, S8, S3, B60, Pyr, B36, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.563" /TUlongSig="NA" /TUlongPSig="NA" /label="S334" promotor_-35 988180..988181 /Source="Nicolas_upshift_promotors" /id="U763" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.937062937062937" /psig="0.998001998001998" /xcortree=461 /SigmaFactorBS="agcgtatcagaacacatttcgtcagaaaattaggtctttcga catGTtcacaacaaaatatgATCCTTTATAATAGCAAAAAaggaggcgagatcatggg a" /listShort="yhdX" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 988195 /Source="Nicolas_upshifts" /id="U763" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.937062937062937" /psig="0.998001998001998" /xcortree=461 /SigmaFactorBS="agcgtatcagaacacatttcgtcagaaaattaggtctttcga catGTtcacaacaaaatatgATCCTTTATAATAGCAAAAAaggaggcgagatcatggg a" /listShort="yhdX" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 988197..988216 /Source="Nicolas_upshift_promotors" /id="U763" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.937062937062937" /psig="0.998001998001998" /xcortree=461 /SigmaFactorBS="agcgtatcagaacacatttcgtcagaaaattaggtctttcga catGTtcacaacaaaatatgATCCTTTATAATAGCAAAAAaggaggcgagatcatggg a" /listShort="yhdX" /GFF_Attribute="listLong" /label="promotor_-10" CDS 988230..988337 /gene="yhdX" /locus_tag="BSU_09630" /old_locus_tag="BSU09630" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388844.1" /db_xref="EnsemblGenomes-Gn:BSU09630" /db_xref="EnsemblGenomes-Tr:CAB12802" /db_xref="InterPro:IPR035384" /db_xref="SubtiList:BG13030" /db_xref="UniProtKB/Swiss-Prot:O07593" /translation="MGKGRIRVEERIKAETDAEMQKATLLDQTQTKKGK*" /label="yhdX CDS" gene 988230..988337 /gene="yhdX" /locus_tag="BSU_09630" /old_locus_tag="BSU09630" /label="yhdX gene" S_feature 988338..988391 /Source="Nicolas_S_feature" /locus_tag="new_1038761_1038814" /HighExp="Sw, BC, LPhT, HiOs, S4, HiTm, S5, B36, S7, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S335" downshifts 988362 /Source="Nicolas_upshifts" /id="D507" /incds=0 /nref=177 /ntot=225 /MaxReadThrough="0.97838" /MaxDrop="7.47175" /score="21.9742676" /energy="-14.5" /TU="NA" /idTUdmin="U762" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature 988442..988461 /Source="Nicolas_upshift_promotors" /id="U764" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.381618381618382" /psig="0.931068931068931" /xcortree=1800 /SigmaFactorBS="tttcgccggggttttgtgctgcataagacatttaaatgaaca tccttacgaataTTTTAGTATAATAAACAATTgattgggatagaggggagacagtcat g" /listShort="yhdY, yhdZ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 988448 /Source="Nicolas_upshifts" /id="U764" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.381618381618382" /psig="0.931068931068931" /xcortree=1800 /SigmaFactorBS="tttcgccggggttttgtgctgcataagacatttaaatgaaca tccttacgaataTTTTAGTATAATAAACAATTgattgggatagaggggagacagtcat g" /listShort="yhdY, yhdZ" /GFF_Attribute="listLong" /label="upshifts" CDS 988486..989601 /gene="mscY" /locus_tag="BSU_09640" /old_locus_tag="BSU09640" /function="16.8: Protect" /function="16.12: Sense" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12077558, 15849754, 16850406, 17665170, 18310427, 19252899" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12077558, 15849754, 16850406, 17665170, 18310427, 19252899; Product type t : transporter" /codon_start=1 /transl_table=11 /product="small conductance mechano-sensitive channel" /protein_id="NP_388845.1" /db_xref="EnsemblGenomes-Gn:BSU09640" /db_xref="EnsemblGenomes-Tr:CAB12803" /db_xref="GOA:O07594" /db_xref="InterPro:IPR006685" /db_xref="InterPro:IPR006686" /db_xref="InterPro:IPR010920" /db_xref="InterPro:IPR011014" /db_xref="InterPro:IPR011066" /db_xref="SubtiList:BG13031" /db_xref="UniProtKB/Swiss-Prot:O07594" /translation="MPDYLQQYFTLDNIIQIGISLAILLVFLILRKLFTRYFFNLLFN LTNRPKTEIFKQVVLAFDKPARWFFVALGLFLAIRYSPFLDEQMPVISKIYRSLIVAL LCWGLCNLTATSSFIFHKVNQRFELDMDDILAPFLSKLLRFVIIALSVSVIAQEFNYD VNGFVAGLGLGGLAFALAAKDTISNFFGGIIIITEKPFTIGDWVETSTVTGSVEDITF RSTRFRTAQGALVTVPNSTLSMEAITNWTRMTKRQITFSIHVSYATPIENLERSIHSL RTMLLEHEGVDNEIIMVNFDTFADSYYNLFFNFYTKTTVWAENLNIREDINYKIIEIL GAEGVQFAYPGQMVVVKQKHESDQFQVNLNKEEKERA*" /label="mscY CDS" gene 988486..989601 /gene="mscY" /locus_tag="BSU_09640" /old_locus_tag="BSU09640" /label="mscY gene" downshifts 989581 /Source="Nicolas_upshifts" /id="D508" /incds=0 /nref=5 /ntot=141 /MaxReadThrough="3.45709" /MaxDrop="3.93891" /score="2.31392404" /energy="-12.3" /TU="U764" /idTUdmin="U764" /TUdmin="-783" /isTUend="FALSE" /label="downshifts" misc_feature 989638..989657 /Source="Nicolas_upshift_promotors" /id="U765" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.937062937062937" /psig=1 /xcortree=3140 /SigmaFactorBS="aaagaggaaaaggaacgggcttaaaagagagacttcgtctga cagaggcggagtctttttCATGGTAAAATAAGAGAAAAaggcggtgttgagttggaaa c" /listShort="yhdZ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 989638 /Source="Nicolas_upshifts" /id="U765" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.937062937062937" /psig=1 /xcortree=3140 /SigmaFactorBS="aaagaggaaaaggaacgggcttaaaagagagacttcgtctga cagaggcggagtctttttCATGGTAAAATAAGAGAAAAaggcggtgttgagttggaaa c" /listShort="yhdZ" /GFF_Attribute="listLong" /label="upshifts" CDS 989671..990414 /gene="srtN" /locus_tag="BSU_09650" /old_locus_tag="BSU09650" /EC_number="3.5.1.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16768447, 19136592, 26708127, 27987242" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16768447, 19136592, 26708127, 27987242; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sirtuin NAD-dependent deacetylase" /protein_id="NP_388846.1" /db_xref="EnsemblGenomes-Gn:BSU09650" /db_xref="EnsemblGenomes-Tr:CAB12804" /db_xref="GOA:O07595" /db_xref="InterPro:IPR003000" /db_xref="InterPro:IPR026590" /db_xref="InterPro:IPR028628" /db_xref="InterPro:IPR029035" /db_xref="SubtiList:BG13032" /db_xref="UniProtKB/Swiss-Prot:O07595" /translation="METFKSILHEAQRIVVLTGAGMSTESGIPDFRSAGGIWTEDASR MEAMSLDYFLSYPRLFWPKFKELFQMKMSGSFEPNEGHLLLAELEKQGKQVDIFTQNI DGLHKKAGSRHVYELHGSIQTAACPACGARYDLPHLLEREVPECTAAGNNGDICGTVL KTDVVLFGDAVMHFDTLYEKLDQADLLLVIGTSLEVAPARFVPEDASLIPGMKKVIIN LEPTYCDSLFDMVIHQKIGEFARSLGMKK*" /label="srtN CDS" gene 989671..990414 /gene="srtN" /locus_tag="BSU_09650" /old_locus_tag="BSU09650" /label="srtN gene" downshifts 990386 /Source="Nicolas_upshifts" /id="D509" /incds=0 /nref=3 /ntot=82 /MaxReadThrough="1.93149" /MaxDrop="2.85561" /score="9.76884826" /energy="-9.2" /TU="NA" /idTUdmin="U765" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(990438..991286) /gene="yheN" /locus_tag="BSU_09660" /old_locus_tag="BSU09660" /EC_number="3.5.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative polysaccharide deacetylase" /protein_id="NP_388847.1" /db_xref="EnsemblGenomes-Gn:BSU09660" /db_xref="EnsemblGenomes-Tr:CAB12805" /db_xref="GOA:O07596" /db_xref="InterPro:IPR002509" /db_xref="InterPro:IPR011330" /db_xref="SubtiList:BG13046" /db_xref="UniProtKB/Swiss-Prot:O07596" /translation="MRQTRGEASPSAVSLAFKFASLAVLCVLLLLMVILGYSNSSTKA KEVTVTTNGQLRDEKESLKLKNDSPDLLIKHLQTKQNMGDKTVYLTFDDGPSAVTTRL LDVLKSADVKATFFMLSPRMNEFKQAVKRAEKEGHALGLHGVTHNNRLFYQTPTSPLK EMQEARDTLQDITGYKTDLVRTPYGSKPSLTASQIRNLEKDGFVYWDWTIDSMDWKYR NSQYVTAVLQQLENMEHSSSSRPNVILMHDLPATVNALPVLINKLKEKGYSFGVLEDT MVPVHE*" /label="yheN CDS" gene complement(990438..991286) /gene="yheN" /locus_tag="BSU_09660" /old_locus_tag="BSU09660" /label="yheN gene" downshifts complement(990462) /Source="Nicolas_upshifts" /id="D510" /incds=0 /nref=126 /ntot=242 /MaxReadThrough="2.03966" /MaxDrop="4.72968" /score="-7.82934513" /energy="-9.2" /TU="NA" /idTUdmin="U767" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 991282..991287 /Source="Nicolas_upshift_promotors" /id="U766" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1125 /SigmaFactorBS="cgaaactgcagaaggagaagcctctcctctcgtttgtCGCAT AacaatctctccattgGCATAAAATCTCTACATAAtgctgtacagcaggcagcttatg a" /listShort="S337, S338, dat" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(991287..991386) /Source="Nicolas_S_feature" /locus_tag="new_1041710_1041809_c" /HighExp="Cold, T3.0H, T2.30H, T3.30H, T4.0H, T2.0H, HPh, C30, T1.30H, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S336" promotor_-10 991303..991321 /Source="Nicolas_upshift_promotors" /id="U766" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1125 /SigmaFactorBS="cgaaactgcagaaggagaagcctctcctctcgtttgtCGCAT AacaatctctccattgGCATAAAATCTCTACATAAtgctgtacagcaggcagcttatg a" /listShort="S337, S338, dat" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 991305 /Source="Nicolas_upshifts" /id="U766" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1125 /SigmaFactorBS="cgaaactgcagaaggagaagcctctcctctcgtttgtCGCAT AacaatctctccattgGCATAAAATCTCTACATAAtgctgtacagcaggcagcttatg a" /listShort="S337, S338, dat" /GFF_Attribute="listLong" /label="upshifts" S_feature 991310..991505 /Source="Nicolas_S_feature" /locus_tag="new_1041733_1041928" /HighExp="S5, S4, S6, S3, S7, S8, LoTm, B36, T5.0H, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S337" promotor_-10 complement(991375..991394) /Source="Nicolas_upshift_promotors" /id="U767" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.57042957042957" /psig=1 /xcortree=2149 /SigmaFactorBS="ttttttccttaaaatctgacatttcgacaaattttctATGTg ctttccagttttaTTCCTGTATACTTGACTGGTaatacataggttgtaaacataaggc a" /listShort="S336, yheN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(991389) /Source="Nicolas_upshifts" /id="U767" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.57042957042957" /psig=1 /xcortree=2149 /SigmaFactorBS="ttttttccttaaaatctgacatttcgacaaattttctATGTg ctttccagttttaTTCCTGTATACTTGACTGGTaatacataggttgtaaacataaggc a" /listShort="S336, yheN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(991409..991412) /Source="Nicolas_upshift_promotors" /id="U767" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.57042957042957" /psig=1 /xcortree=2149 /SigmaFactorBS="ttttttccttaaaatctgacatttcgacaaattttctATGTg ctttccagttttaTTCCTGTATACTTGACTGGTaatacataggttgtaaacataaggc a" /listShort="S336, yheN" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 991504..991523 /Source="Nicolas_upshift_promotors" /id="U768" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2940 /SigmaFactorBS="aaataaactcctttccgctatagatctcttgatctttctgtt tttcagcttgtccaaTATGGTAGAATTAGTGATAAtgacagcttgaatgacatcaggg a" /listShort="S338, dat" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 991507..991570 /Source="Nicolas_S_feature" /locus_tag="new_1041930_1041993" /HighExp="BC, T2.30H, T3.0H, T3.30H, T4.0H, T5.0H, T2.0H, T1.30H, S4, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S338" upshifts 991507 /Source="Nicolas_upshifts" /id="U768" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2940 /SigmaFactorBS="aaataaactcctttccgctatagatctcttgatctttctgtt tttcagcttgtccaaTATGGTAGAATTAGTGATAAtgacagcttgaatgacatcaggg a" /listShort="S338, dat" /GFF_Attribute="listLong" /label="upshifts" CDS 991571..992419 /gene="dat" /locus_tag="BSU_09670" /old_locus_tag="BSU09670" /EC_number="2.6.1.21" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9003455, 17005988; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanine aminotransferase" /protein_id="NP_388848.1" /db_xref="EnsemblGenomes-Gn:BSU09670" /db_xref="EnsemblGenomes-Tr:CAB12806" /db_xref="GOA:O07597" /db_xref="InterPro:IPR001544" /db_xref="InterPro:IPR005784" /db_xref="InterPro:IPR018300" /db_xref="InterPro:IPR036038" /db_xref="SubtiList:BG13045" /db_xref="UniProtKB/Swiss-Prot:O07597" /translation="MKVLVNGRLIGRSEASIDLEDRGYQFGDGIYEVIRVYKGVLFGL REHAERFFRSAAEIGISLPFSIEDLEWDLQKLVQENAVSEGAVYIQTTRGVAPRKHQY EAGLEPQTTAYTFTVKKPEQEQAYGVAAITDEDLRWLRCDIKSLNLLYNVMTKQRAYE AGAFEAILLRDGVVTEGTSSNVYAVINGTVRTHPANRLILNGITRMNILGLIEKNGIK LDETPVSEEELKQAEEIFISSTTAEIIPVVTLDGQSIGSGKPGPVTKQLQAAFQESIQ QAASIS*" /label="dat CDS" gene 991571..992419 /gene="dat" /locus_tag="BSU_09670" /old_locus_tag="BSU09670" /label="dat gene" downshifts 992410 /Source="Nicolas_upshifts" /id="D511" /incds=0 /nref=232 /ntot=261 /MaxReadThrough="2.27201" /MaxDrop="6.88888" /score="21.6239924" /energy="-11.5" /TU="U768" /idTUdmin="U766" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(992462..993823) /gene="nhaC" /locus_tag="BSU_09680" /old_locus_tag="BSU09680" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10735849, 11274110, 15849754, 16850406, 17937670" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10735849, 11274110, 15849754, 16850406, 17937670; Product type t : transporter" /codon_start=1 /transl_table=11 /product="Na+/H+ antiporter" /protein_id="NP_388849.1" /db_xref="EnsemblGenomes-Gn:BSU09680" /db_xref="EnsemblGenomes-Tr:CAB12807" /db_xref="GOA:O07553" /db_xref="InterPro:IPR004770" /db_xref="InterPro:IPR018461" /db_xref="SubtiList:BG13044" /db_xref="UniProtKB/Swiss-Prot:O07553" /translation="MDSQKKLTFPLAVGLFIFMLCIIISCLFLLHVEPHIPLFLSVVM LSAAALWFGFPWKSIEKGIVDGIKNGVQPIIVLALIGILIGAWMYSGAIPTMTVYALS FIEPSHLLLTALFSCMIISTLVGSSLTTVSTIGVALIGVASAAGVPLEWTAGAVICGA CFGDKMSPMSDTTNFAAGIGEIPIFEHIRHMMGTTIPALLITVVLFYFLGSSVSADAA STDNIQQVITGIKDAANVTPWALLSPLLVVLLAMKRVSVIPVLTAGIISSGILTAIFV PYSSLQAFMTALQNGTTFETDNEAAAKIINRGGLQSMMGSVSLIMIAFALGGLMEKIG LISALLEGVMKGIRSKGRLVAATVCSSIGVNLATGEQYLSILIPGQSFKSLYDKRNIQ RKFLTRSLEDGGTLINPLIPWGVSGAFMASALGVPVIDYIPFTFFLYISPMISILIGF VKK*" /label="nhaC CDS" gene complement(992462..993823) /gene="nhaC" /locus_tag="BSU_09680" /old_locus_tag="BSU09680" /label="nhaC gene" downshifts complement(992486) /Source="Nicolas_upshifts" /id="D512" /incds=0 /nref=7 /ntot=77 /MaxReadThrough="0.50034" /MaxDrop="3.60175" /score="1.04025421" /energy="-11.5" /TU="NA" /idTUdmin="U769" /TUdmin=22 /isTUend="TRUE" /label="downshifts" S_feature complement(993824..993894) /Source="Nicolas_S_feature" /locus_tag="new_1044247_1044317_c" /HighExp="B60, G135, Etha, LBGexp, G150, Diami, Paraq, G180, H2O2, Gly" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="0.96, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S339" misc_feature complement(993867..993886) /Source="Nicolas_upshift_promotors" /id="U769" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.926073926073926" /psig="0.96003996003996" /xcortree=2470 /SigmaFactorBS="agtgagcacgccctgtgctcacttcttttatattcataattg tgaaaaaacatagattttcgttttttTCTGTTATAATGCTTTCGTGcccaaaagcaca a" /listShort="S339, nhaC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(993894) /Source="Nicolas_upshifts" /id="U769" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.926073926073926" /psig="0.96003996003996" /xcortree=2470 /SigmaFactorBS="agtgagcacgccctgtgctcacttcttttatattcataattg tgaaaaaacatagattttcgttttttTCTGTTATAATGCTTTCGTGcccaaaagcaca a" /listShort="S339, nhaC" /GFF_Attribute="listLong" /label="upshifts" CDS complement(993950..994450) /gene="nhaX" /locus_tag="BSU_09690" /old_locus_tag="BSU09690" /function="16.12: Sense" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11988534, 16159758, 27464829; Product type f: factor" /codon_start=1 /transl_table=11 /product="stress response protein, UspA family" /protein_id="NP_388850.2" /db_xref="EnsemblGenomes-Gn:BSU09690" /db_xref="EnsemblGenomes-Tr:CAB12808" /db_xref="GOA:O07552" /db_xref="InterPro:IPR006015" /db_xref="InterPro:IPR006016" /db_xref="InterPro:IPR014729" /db_xref="SubtiList:BG13043" /db_xref="UniProtKB/Swiss-Prot:O07552" /translation="MFHADRIIVAFDGSENSKKALLTAIDLAKTVNAAITVAHSHDMK DNQTVIDPPRPAAEASYISGGMTSVPDPLISDVTSPEPMIYEDRTEEVIAEARMMLNE QQADGDIDILEGDPAESIIEHANRISADMIVTGSRDQNRLKKLIFGSVSEKLSAKSDI PVLIVK*" /label="nhaX CDS" gene complement(993950..994450) /gene="nhaX" /locus_tag="BSU_09690" /old_locus_tag="BSU09690" /label="nhaX gene" downshifts complement(993982) /Source="Nicolas_upshifts" /id="D513" /incds=0 /nref=10 /ntot=63 /MaxReadThrough="4.74071" /MaxDrop="5.69273" /score="4.44189378" /energy="-12.2" /TU="U770" /idTUdmin="U770" /TUdmin="-1320" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(994472..994490) /Source="Nicolas_upshift_promotors" /id="U770" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=208 /SigmaFactorBS="aaacaaaaccttttattgtcaatcattacttgaataggaaaA GGTTAAttgtgctcaaattcGGGTAGTAGTGTTGTAAGAcgctttgaaagggtgagaa g" /listShort="nhaX, S339, nhaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(994492) /Source="Nicolas_upshifts" /id="U770" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=208 /SigmaFactorBS="aaacaaaaccttttattgtcaatcattacttgaataggaaaA GGTTAAttgtgctcaaattcGGGTAGTAGTGTTGTAAGAcgctttgaaagggtgagaa g" /listShort="nhaX, S339, nhaC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(994505..994511) /Source="Nicolas_upshift_promotors" /id="U770" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=208 /SigmaFactorBS="aaacaaaaccttttattgtcaatcattacttgaataggaaaA GGTTAAttgtgctcaaattcGGGTAGTAGTGTTGTAAGAcgctttgaaagggtgagaa g" /listShort="nhaX, S339, nhaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 994529..994536 /Source="Nicolas_upshift_promotors" /id="U771" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.918081918081918" /psig=1 /xcortree=416 /SigmaFactorBS="ctacccgaatttgagcacaattaaccttttcctattcaagta atGATTGACAataaaaggttttgtTTATATGATGATAAAAAGATgaaatcagaatgga a" /listShort="S340, yheJ, S341, yheI, yheH" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 994544..994613 /Source="Nicolas_S_feature" /locus_tag="new_1044967_1045036" /HighExp="C90, M9-stat, BC, T1.30H, T3.30H, Sw, T5.0H, GM 15, T3.0H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S340" upshifts 994545 /Source="Nicolas_upshifts" /id="U771" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.918081918081918" /psig=1 /xcortree=416 /SigmaFactorBS="ctacccgaatttgagcacaattaaccttttcctattcaagta atGATTGACAataaaaggttttgtTTATATGATGATAAAAAGATgaaatcagaatgga a" /listShort="S340, yheJ, S341, yheI, yheH" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 994551..994570 /Source="Nicolas_upshift_promotors" /id="U771" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.918081918081918" /psig=1 /xcortree=416 /SigmaFactorBS="ctacccgaatttgagcacaattaaccttttcctattcaagta atGATTGACAataaaaggttttgtTTATATGATGATAAAAAGATgaaatcagaatgga a" /listShort="S340, yheJ, S341, yheI, yheH" /GFF_Attribute="listLong" /label="promotor_-10" CDS 994614..994775 /gene="bmrB" /locus_tag="BSU_09700" /old_locus_tag="BSU09700" /experiment="publication(s) with functional evidences, PMID:25217586" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25217586; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator leader peptide" /protein_id="NP_388851.1" /db_xref="EnsemblGenomes-Gn:BSU09700" /db_xref="EnsemblGenomes-Tr:CAB12809" /db_xref="SubtiList:BG13042" /db_xref="UniProtKB/Swiss-Prot:O07551" /translation="MFIKQFHIGAANLLFCFRERFFRSDRALKSAVRNISVKKGMELT LHAFFIYKI*" /label="bmrB CDS" gene 994614..994775 /gene="bmrB" /locus_tag="BSU_09700" /old_locus_tag="BSU09700" /label="bmrB gene" downshifts 994705 /Source="Nicolas_upshifts" /id="D514" /incds=1 /nref=29 /ntot=180 /MaxReadThrough="5.31538" /MaxDrop="4.59672" /score="25.6910195" /energy="-14.4" /TU="U771" /idTUdmin="U768" /TUdmin=2273 /isTUend="FALSE" /label="downshifts" S_feature 994776..994894 /Source="Nicolas_S_feature" /locus_tag="new_1045199_1045317" /HighExp="LPhT, S7, S6, T-1.10H, Sw, LBGstat, S5, T-0.40H, S8, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S341" CDS 994895..996652 /gene="bmrC" /locus_tag="BSU_09710" /old_locus_tag="BSU09710" /function="16.1: Circulate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15855514, 16487324, 19167342, 21602923, 25217586" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15855514, 16487324, 19167342, 21602923, 25217586; Product type t : transporter" /codon_start=1 /transl_table=11 /product="efflux ABC transporter (ATP-binding protein)" /protein_id="NP_388852.1" /db_xref="EnsemblGenomes-Gn:BSU09710" /db_xref="EnsemblGenomes-Tr:CAB12810" /db_xref="GOA:O07550" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG13041" /db_xref="UniProtKB/Swiss-Prot:O07550" /translation="MFSVLKKLGWFFKAYWLRYTIAIVLLLAVNVIEMFPPKLLGNAI DDMKAGAFTAEGLLFYIGIFFVLTAAVYIMSYFWMHQLFGGANLMEKILRTKLMGHLL TMSPPFYEKNRTGDLMARGTNDLQAVSLTTGFGILTLVDSTMFMMTIFLTMGFLISWK LTFAAIIPLPVMAIAISLYGSKIHERFTEAQNAFGALNDRVLESVSGVRVIRAYVQET NDVRRFNEMTADVYQKNMKVAFIDSLFEPTVKLLVGASYLIGLGYGAFLVFRNELTLG ELVSFNVYLGMMIWPMFAIGELINVMQRGNASLDRVNETLSYETDVTDPKQPADLKEP GDIVFSHVSFTYPSSTSDNLQDISFTVRKGQTVGIAGKTGSGKTTIIKQLLRQYPPGE GSITFSGVPIQQIPLDRLRGWIGYVPQDHLLFSRTVKENILYGKQDATDKEVQQAIAE AHFEKDLHMLPSGLETMVGEKGVALSGGQKQRISIARALMANPEILILDDSLSAVDAK TEAAIIKNIRENRKGKTTFILTHRLSAVEHADLILVMDGGVIAERGTHQELLANNGWY REQYERQQLFTAEEGGAGA*" /label="bmrC CDS" gene 994895..996652 /gene="bmrC" /locus_tag="BSU_09710" /old_locus_tag="BSU09710" /label="bmrC gene" CDS 996649..998670 /gene="bmrD" /locus_tag="BSU_09720" /old_locus_tag="BSU09720" /function="16.1: Circulate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15855514, 16487324, 19167342, 21602923, 25217586" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15855514, 16487324, 19167342, 21602923, 25217586; Product type t : transporter" /codon_start=1 /transl_table=11 /product="efflux ABC transporter (ATP-binding subunit)" /protein_id="NP_388853.1" /db_xref="EnsemblGenomes-Gn:BSU09720" /db_xref="EnsemblGenomes-Tr:CAB12811" /db_xref="GOA:O07549" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG13040" /db_xref="UniProtKB/Swiss-Prot:O07549" /translation="MKIGKTLWRYALLYRKLLITAVLLLTVAVGAELTGPFIGKKMID DHILGIEKTWYEAAEKDKNAVQFHGVSYVREDRLQEPVSKAKEAHIYQVGMAFYFVDQ AVSFDGNRTVSDGKLTITNGDKSRAYAAEKLTKQELFQFYQPEIKGMVLLICLYGGLL VFSVFFQYGQHYLLQMSANRIIQKMRQDVFSHIQKMPIRYFDNLPAGKVVARITNDTE AIRDLYVTVLSTFVTSGIYMFGIFTALFLLDVKLAFVCLAIVPIIWLWSVIYRRYASY YNQKIRSINSDINAKMNESIQGMTIIQAFRHQKETMREFEELNESHFYFQNRMLNLNS LMSHNLVNVIRNLAFVCLIWHFGGASLNAAGIVSIGVLYAFVDYLNRLFQPITGIVNQ FSKLELARVSAGRVFELLEEKNTEEAGEPAKERALGRVEFRDVSFAYQEGEEVLKHIS FTAQKGETVALVGHTGSGKSSILNLLFRFYDAQKGDVLIDGKSIYNMSRQELRSHMGI VLQDPYLFSGTIGSNVSLDDERMTEEEIKNALRQVGAEPLLKKLPKGINEPVIEKGST LSSGERQLISFARALAFDPAILILDEATAHIDTETEAVIQKALDVVKQGRTTFVIAHR LSTIRNADQILVLDKGEIVERGNHEELMALEGQYYQMYELQKGQKHSIA*" /label="bmrD CDS" gene 996649..998670 /gene="bmrD" /locus_tag="BSU_09720" /old_locus_tag="BSU09720" /label="bmrD gene" downshifts 998658 /Source="Nicolas_upshifts" /id="D515" /incds=0 /nref=69 /ntot=230 /MaxReadThrough="0.741399999999999" /MaxDrop="5.11492" /score="9.67206405" /energy="-10.9" /TU="NA" /idTUdmin="U771" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(998719..999339) /gene="yheG" /locus_tag="BSU_09730" /old_locus_tag="BSU09730" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NADH-flavin oxidoreductase" /protein_id="NP_388854.1" /db_xref="EnsemblGenomes-Gn:BSU09730" /db_xref="EnsemblGenomes-Tr:CAB12812" /db_xref="InterPro:IPR016040" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13039" /db_xref="UniProtKB/Swiss-Prot:O07548" /translation="MKIALLGASGRVGQAFLTQAAADERFDIFALIRSQHADLPLSKD RTVMGNARRLEDVKKIMENAEIVISCLGTDGDDTLSTAMAHILSVMEEQHIKRLITIG TAGILDSRYEPGKYRFETNESKRKQTRAAKEHAKVYEMLKESSLDWTIICPTYLPDGT ATGVYRTERNVLPEGGTSISVGDTADFLYRELVTGEYVGNRVGLAY*" /label="yheG CDS" gene complement(998719..999339) /gene="yheG" /locus_tag="BSU_09730" /old_locus_tag="BSU09730" /label="yheG gene" downshifts complement(998734) /Source="Nicolas_upshifts" /id="D516" /incds=0 /nref=19 /ntot=169 /MaxReadThrough="1.82652" /MaxDrop="3.00293" /score="-0.293143554" /energy="-10.9" /TU="NA" /idTUdmin="U772" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_no_box 999324..999424 /Source="Nicolas_upshift_promotors" /id="U773" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.45954045954046" /psig="0.043956043956044" /xcortree=770 /SigmaFactorBS="ataaagcgattttcattaaaaaacctcctcgcctttcattat aaaaggatgttctcagtttgaacagcgcgggaaagaatacctgtacaaataaacagaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-10 complement(999353..999372) /Source="Nicolas_upshift_promotors" /id="U772" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.844155844155844" /psig="0.955044955044955" /xcortree=2213 /SigmaFactorBS="catcgttctgtttatttgtacaggtattctttcccgcgCTGT tcaaactgagaacaTCCTTTTATAATGAAAGGCGaggaggttttttaatgaaaatcgc t" /listShort="yheG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(999368) /Source="Nicolas_upshifts" /id="U772" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.844155844155844" /psig="0.955044955044955" /xcortree=2213 /SigmaFactorBS="catcgttctgtttatttgtacaggtattctttcccgcgCTGT tcaaactgagaacaTCCTTTTATAATGAAAGGCGaggaggttttttaatgaaaatcgc t" /listShort="yheG" /GFF_Attribute="listLong" /label="upshifts" CDS complement(999378..999503) /gene="yheF" /locus_tag="BSU_09740" /old_locus_tag="BSU09740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388855.1" /db_xref="EnsemblGenomes-Gn:BSU09740" /db_xref="EnsemblGenomes-Tr:CAB12813" /db_xref="SubtiList:BG13038" /db_xref="UniProtKB/Swiss-Prot:O07547" /translation="MSFITIVNWELVQFVSVSMIHEYVSHRSVYLYRYSFPRCSN*" /label="yheF CDS" gene complement(999378..999503) /gene="yheF" /locus_tag="BSU_09740" /old_locus_tag="BSU09740" /label="yheF gene" upshifts 999384 /Source="Nicolas_upshifts" /id="U773" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.45954045954046" /psig="0.043956043956044" /xcortree=770 /SigmaFactorBS="ataaagcgattttcattaaaaaacctcctcgcctttcattat aaaaggatgttctcagtttgaacagcgcgggaaagaatacctgtacaaataaacagaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(999387..999390) /Source="Nicolas_upshift_promotors" /id="U772" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.844155844155844" /psig="0.955044955044955" /xcortree=2213 /SigmaFactorBS="catcgttctgtttatttgtacaggtattctttcccgcgCTGT tcaaactgagaacaTCCTTTTATAATGAAAGGCGaggaggttttttaatgaaaatcgc t" /listShort="yheG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(999517..999536) /Source="Nicolas_upshift_promotors" /id="U774" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1332 /SigmaFactorBS="agggcgcggtttccgcgctctctttatTTTGTCACCCttttt tcctgctcCACATATCCTAGAAAAAAAGggagggaatcggggtgtcattcatcaccat t" /listShort="yheF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(999526) /Source="Nicolas_upshifts" /id="U774" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1332 /SigmaFactorBS="agggcgcggtttccgcgctctctttatTTTGTCACCCttttt tcctgctcCACATATCCTAGAAAAAAAGggagggaatcggggtgtcattcatcaccat t" /listShort="yheF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(999550..999559) /Source="Nicolas_upshift_promotors" /id="U774" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1332 /SigmaFactorBS="agggcgcggtttccgcgctctctttatTTTGTCACCCttttt tcctgctcCACATATCCTAGAAAAAAAGggagggaatcggggtgtcattcatcaccat t" /listShort="yheF" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 999582 /Source="Nicolas_upshifts" /id="D517" /incds=0 /nref=6 /ntot=22 /MaxReadThrough="0.352760000000001" /MaxDrop="4.67633" /score="9.67206405" /energy="-10.9" /TU="NA" /idTUdmin="U773" /TUdmin=88 /isTUend="FALSE" /label="downshifts" CDS complement(999608..999811) /gene="sspB" /locus_tag="BSU_09750" /old_locus_tag="BSU09750" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:3009398, 9572981, 16707666, 19659696, 26790838" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3009398, 9572981, 16707666, 19659696, 26790838; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein (beta-type SASP)" /protein_id="NP_388856.1" /db_xref="EnsemblGenomes-Gn:BSU09750" /db_xref="EnsemblGenomes-Tr:CAB12814" /db_xref="GOA:P04832" /db_xref="InterPro:IPR001448" /db_xref="InterPro:IPR018126" /db_xref="SubtiList:BG10787" /db_xref="UniProtKB/Swiss-Prot:P04832" /translation="MANQNSSNDLLVPGAAQAIDQMKLEIASEFGVNLGADTTSRANG SVGGEITKRLVSFAQQQMGGRVQ*" /label="sspB CDS" gene complement(999608..999811) /gene="sspB" /locus_tag="BSU_09750" /old_locus_tag="BSU09750" /label="sspB gene" downshifts complement(999613) /Source="Nicolas_upshifts" /id="D518" /incds=0 /nref=72 /ntot=93 /MaxReadThrough="1.27819" /MaxDrop="8.55895" /score="22.2113888" /energy="-16" /TU="NA" /idTUdmin="U776" /TUdmin=1 /isTUend="TRUE" /label="downshifts" S_feature complement(999812..999922) /Source="Nicolas_S_feature" /locus_tag="new_1050235_1050345_c" /HighExp="S8, S5, S7, S6, S4, G/S, Pyr, ferm, BT, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S342" promotor_no_box 999852..999952 /Source="Nicolas_upshift_promotors" /id="U775" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.665334665334665" /psig="0.090909090909091" /xcortree=696 /SigmaFactorBS="ggagttgcaccaatctgtgaacccttctcgggtgtcactgcc gcctcggcgtaacccaatgctttgccggcttgttactacgtattatgttaaaatggcc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 999912 /Source="Nicolas_upshifts" /id="U775" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.665334665334665" /psig="0.090909090909091" /xcortree=696 /SigmaFactorBS="ggagttgcaccaatctgtgaacccttctcgggtgtcactgcc gcctcggcgtaacccaatgctttgccggcttgttactacgtattatgttaaaatggcc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(999928) /Source="Nicolas_upshifts" /id="U776" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=836 /SigmaFactorBS="ctcaagatttaccacacaattctcCGCATGAttttccggcca tttTAACATAATACGtagtaacaagccggcaaagcattgggttacgccgaggcggcag t" /listShort="S342, sspB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(999932..999943) /Source="Nicolas_upshift_promotors" /id="U776" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=836 /SigmaFactorBS="ctcaagatttaccacacaattctcCGCATGAttttccggcca tttTAACATAATACGtagtaacaagccggcaaagcattgggttacgccgaggcggcag t" /listShort="S342, sspB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(999958..999964) /Source="Nicolas_upshift_promotors" /id="U776" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=836 /SigmaFactorBS="ctcaagatttaccacacaattctcCGCATGAttttccggcca tttTAACATAATACGtagtaacaagccggcaaagcattgggttacgccgaggcggcag t" /listShort="S342, sspB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1000020..1000238) /gene="yheE" /locus_tag="BSU_09760" /old_locus_tag="BSU09760" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein (sporulation / germination island)" /protein_id="NP_388857.1" /db_xref="EnsemblGenomes-Gn:BSU09760" /db_xref="EnsemblGenomes-Tr:CAB12815" /db_xref="InterPro:IPR017263" /db_xref="SubtiList:BG13037" /db_xref="UniProtKB/Swiss-Prot:O07546" /translation="MAVMISHFSWKPLFPKEKLPGWKISFYYKGTHYEGIYHKSGEIE WGDLFPARADEPALTNEIHELMLFHIYD*" /label="yheE CDS" gene complement(1000020..1000238) /gene="yheE" /locus_tag="BSU_09760" /old_locus_tag="BSU09760" /label="yheE gene" downshifts complement(1000054) /Source="Nicolas_upshifts" /id="D519" /incds=0 /nref=5 /ntot=83 /MaxReadThrough="0.43384" /MaxDrop="3.42951" /score="37.4339943" /energy="-11.8" /TU="NA" /idTUdmin="U777" /TUdmin=110 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1000279..1000298) /Source="Nicolas_upshift_promotors" /id="U777" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.609390609390609" /psig="0.996003996003996" /xcortree=419 /SigmaFactorBS="ctttatccaaagctgggacaaactgcatatttaggccTCTTC AATgatgttctgaaacAATGATACAATGAACATAAGccgtttttatttaggtcaattg a" /listShort="yheE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1000296) /Source="Nicolas_upshifts" /id="U777" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.609390609390609" /psig="0.996003996003996" /xcortree=419 /SigmaFactorBS="ctttatccaaagctgggacaaactgcatatttaggccTCTTC AATgatgttctgaaacAATGATACAATGAACATAAGccgtttttatttaggtcaattg a" /listShort="yheE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1000312..1000319) /Source="Nicolas_upshift_promotors" /id="U777" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.609390609390609" /psig="0.996003996003996" /xcortree=419 /SigmaFactorBS="ctttatccaaagctgggacaaactgcatatttaggccTCTTC AATgatgttctgaaacAATGATACAATGAACATAAGccgtttttatttaggtcaattg a" /listShort="yheE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1000388..1001749) /gene="spaD" /locus_tag="BSU_09770" /old_locus_tag="BSU09770" /function="16.5: Explore" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15231775, 25035995" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15231775, 25035995; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat associated protein" /protein_id="NP_388858.2" /db_xref="EnsemblGenomes-Gn:BSU09770" /db_xref="EnsemblGenomes-Tr:CAB12816" /db_xref="GOA:O07545" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR026838" /db_xref="SubtiList:BG13036" /db_xref="UniProtKB/Swiss-Prot:O07545" /translation="MNPKRFLIGIDKTSENTLFLPSSLKQDGLLHAAFGTKVVRCHVA YRRHLEQTVLLSENLFHELLLPHRSRADILIHDHTVHIGPLVGIFTAGFTVSLERPFK DRSLFFSKLVTLHEQAGGYCFVFGAHQINWEEGTIEGLLYRENGWEKKIVPLPNVVYD RLPNRKIEDSLLLQHTKKRLIDEYQIPWFNKTFFNKWNVHQLLEKDPRTAPFLPRSEL TPSVELIDELCGAYKKVYIKPANGALGTGIYQLTRTDGGLTVKHTNDAKTFTSIDYSD AASFLAEFQKHHNPSDFLIQQGVDLIEFQGKPADFRVHTNKNRKGKWTVTAIAVKISG KNSITTHLSNGGTVKTLAEVYDDPAERVEVIKKLSAAALTASHVLHDHIEGFIGEIGF DFGIDQNGKVWMFEANSRPGRSIFSHPNLHHVDSLTKRRSFEYASYLSEKAITSPEAL WPS*" /label="spaD CDS" gene complement(1000388..1001749) /gene="spaD" /locus_tag="BSU_09770" /old_locus_tag="BSU09770" /label="spaD gene" downshifts complement(1000406) /Source="Nicolas_upshifts" /id="D520" /incds=0 /nref=3 /ntot=26 /MaxReadThrough="2.33323" /MaxDrop="3.7968" /score="37.4339943" /energy="-11.8" /TU="NA" /idTUdmin="U779" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1000450) /Source="Nicolas_upshifts" /id="D521" /incds=1 /nref=2 /ntot=45 /MaxReadThrough="5.29177" /MaxDrop="3.36501" /score="37.4339943" /energy="-11.8" /TU="U779" /idTUdmin="U779" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" CDS complement(1001739..1002830) /gene="spaC" /locus_tag="BSU_09780" /old_locus_tag="BSU09780" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15231775, 25035995; Product type f: factor" /codon_start=1 /transl_table=11 /product="spore coat associated protein, subunit C" /protein_id="NP_388859.1" /db_xref="EnsemblGenomes-Gn:BSU09780" /db_xref="EnsemblGenomes-Tr:CAB12817" /db_xref="GOA:O07544" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR026838" /db_xref="SubtiList:BG13035" /db_xref="UniProtKB/Swiss-Prot:O07544" /translation="MITLGFMSLSRQHEADYSAELAKRAPEFGIRFIRFTPFDISPDT LRVKASVYHSASSTWNETEMAIPDYIYDRCFYGKDSHSQKAKPIVEWLKKYPKTEFIG RGLPDKWTVLHDLQQHSVINPYIPETIKVSRYEQIHSFLSKEKACILKPAFGAGGRGV ILLKLGKKNITATYHIGKDKQTKTFSNQTSFKTWCKKVLQHQYLLQPYLNIQDKEQYP CDIRLFMEKNEAGEWNTVGKAVRRGYKHGLLANLSGGSDALTFDSWFEDIPKKQQVVL LDDVFSITQSVPYYLDERYGPLFELGLDICLAKDGRIWILDINSKPGRKSILRVSPEQ KEQLYTCPLKRCQYLFSEQSQKGVLPRES*" /label="spaC CDS" gene complement(1001739..1002830) /gene="spaC" /locus_tag="BSU_09780" /old_locus_tag="BSU09780" /label="spaC gene" promotor_-10 complement(1002154..1002168) /Source="Nicolas_upshift_promotors" /id="U778" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.63936063936064" /psig="0.63936063936064" /xcortree=613 /SigmaFactorBS="aatatttgcttcagccttacttaaacattcaagataAGGAAC AATacccttgtgatatTCGTCTGTTTATGGAaaaaaacgaagcaggtgaatggaatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1002166) /Source="Nicolas_upshifts" /id="U778" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.63936063936064" /psig="0.63936063936064" /xcortree=613 /SigmaFactorBS="aatatttgcttcagccttacttaaacattcaagataAGGAAC AATacccttgtgatatTCGTCTGTTTATGGAaaaaaacgaagcaggtgaatggaatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1002182..1002190) /Source="Nicolas_upshift_promotors" /id="U778" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.63936063936064" /psig="0.63936063936064" /xcortree=613 /SigmaFactorBS="aatatttgcttcagccttacttaaacattcaagataAGGAAC AATacccttgtgatatTCGTCTGTTTATGGAaaaaaacgaagcaggtgaatggaatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1002831..1002936) /Source="Nicolas_S_feature" /locus_tag="new_1053254_1053359_c" /HighExp="S4, B36, S5, S6, S7, S8, B60, S3, T5.0H, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S343" promotor_-10 complement(1002920..1002938) /Source="Nicolas_upshift_promotors" /id="U779" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1099 /SigmaFactorBS="ggagacaaattcctgttcttagaaaatcagcttgttcttttG GAATAgggcaaggtggagaaTCGTATTCTGTAAAGTAGAataccgtcagctgcgttcg t" /listShort="S343, yheC, yheD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1002940) /Source="Nicolas_upshifts" /id="U779" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1099 /SigmaFactorBS="ggagacaaattcctgttcttagaaaatcagcttgttcttttG GAATAgggcaaggtggagaaTCGTATTCTGTAAAGTAGAataccgtcagctgcgttcg t" /listShort="S343, yheC, yheD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1002954..1002959) /Source="Nicolas_upshift_promotors" /id="U779" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1099 /SigmaFactorBS="ggagacaaattcctgttcttagaaaatcagcttgttcttttG GAATAgggcaaggtggagaaTCGTATTCTGTAAAGTAGAataccgtcagctgcgttcg t" /listShort="S343, yheC, yheD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1003002..1003009 /Source="Nicolas_upshift_promotors" /id="U780" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2000 /SigmaFactorBS="ttttctaagaacaggaatttgtctcctCGTTTGCTaagtgat tgcatgaGCCTCTATAATACGTATAGGtacataatctatatgaaaaaagctgaagcac a" /listShort="yheB, S344, yheA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1003024..1003043 /Source="Nicolas_upshift_promotors" /id="U780" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2000 /SigmaFactorBS="ttttctaagaacaggaatttgtctcctCGTTTGCTaagtgat tgcatgaGCCTCTATAATACGTATAGGtacataatctatatgaaaaaagctgaagcac a" /listShort="yheB, S344, yheA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1003035 /Source="Nicolas_upshifts" /id="U780" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2000 /SigmaFactorBS="ttttctaagaacaggaatttgtctcctCGTTTGCTaagtgat tgcatgaGCCTCTATAATACGTATAGGtacataatctatatgaaaaaagctgaagcac a" /listShort="yheB, S344, yheA" /GFF_Attribute="listLong" /label="upshifts" CDS 1003097..1004230 /gene="yheB" /locus_tag="BSU_09790" /old_locus_tag="BSU09790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16684363" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388860.1" /db_xref="EnsemblGenomes-Gn:BSU09790" /db_xref="EnsemblGenomes-Tr:CAB12818" /db_xref="GOA:O07543" /db_xref="InterPro:IPR007383" /db_xref="InterPro:IPR016991" /db_xref="SubtiList:BG13034" /db_xref="UniProtKB/Swiss-Prot:O07543" /translation="MGIAGTFIFMIVIGAAIGAVTNHLAIQMLFRPYKAYYLFGKRVP FTPGLIPRRRDELAKQMGLMVVNHLLTPEGIKKRLVSDAAKTQALRVGEQLIQKLSLS EVTVKEALEKAGMKRPEKAADAWISSWTDDKLHELFRQYGDQSLKELVPIEVQEKLEE KIPMISGYILSRSVRYFESDEGKIRLGNMIDDFLKERGMLGSMVQLFLGNSSLADRVL PELLKFLRNEETNKLLSDLLKNEWGKLREYTFNEADEKWNAKALIFSLKRRVLQAFST APFFNNTIGTLTVRYESELTQQMLPALLDKLLEGISSNLESVLKRLRLEEIVKEQVDQ FPVERLEEMVLSISKKEFKMITYLGGLLGGIIGAIQALFVILF*" /label="yheB CDS" gene 1003097..1004230 /gene="yheB" /locus_tag="BSU_09790" /old_locus_tag="BSU09790" /label="yheB gene" S_feature 1004231..1004322 /Source="Nicolas_S_feature" /locus_tag="new_1054654_1054745" /HighExp="S4, S5, S6, BT, S3, S7, dia15, B36, G/S, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S344" CDS 1004323..1004676 /gene="yheA" /locus_tag="BSU_09800" /old_locus_tag="BSU09800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 19429628, 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388861.1" /db_xref="EnsemblGenomes-Gn:BSU09800" /db_xref="EnsemblGenomes-Tr:CAB12819" /db_xref="InterPro:IPR010368" /db_xref="InterPro:IPR023378" /db_xref="PDB:2OEE" /db_xref="SubtiList:BG13033" /db_xref="UniProtKB/Swiss-Prot:O07542" /translation="MAVNFYDVAYDLENALRGSEEFTRLKNLYDEVNADESAKRMFEN FRDVQLRLQQKQMAGEEITQEEVTQAQKTVALVQQHEKISQLMEAEQRMSMLIGELNK IIMKPLEELYGSVEG*" /label="yheA CDS" gene 1004323..1004676 /gene="yheA" /locus_tag="BSU_09800" /old_locus_tag="BSU09800" /label="yheA gene" downshifts 1004664 /Source="Nicolas_upshifts" /id="D522" /incds=0 /nref=159 /ntot=259 /MaxReadThrough="1.55668" /MaxDrop="5.9901" /score="24.5275597" /energy="-12.3" /TU="NA" /idTUdmin="U780" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1004720..1005793) /gene="yhaZ" /locus_tag="BSU_09810" /old_locus_tag="BSU09810" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16267290, 22933559" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388862.1" /db_xref="EnsemblGenomes-Gn:BSU09810" /db_xref="EnsemblGenomes-Tr:CAB12820" /db_xref="GOA:O07541" /db_xref="InterPro:IPR011989" /db_xref="InterPro:IPR014825" /db_xref="InterPro:IPR016024" /db_xref="InterPro:IPR021133" /db_xref="SubtiList:BG13002" /db_xref="UniProtKB/Swiss-Prot:O07541" /translation="MADLKEIYNEELISQLIHHVRSSYPDFNKNRFLDTLRLEDWPEL TLKERMRRVTVSLYETLPKQYVEALTILRDTAPHFKGLSGILFPDYVEQYGLAHWEES IKALESFTQYSTSEFAVRPFLLLDQEKMIAQLLAWSEHKNEHVRRLASEGSRPRLPWG KSIPALKSDPSPVLPILEKLMQDESLYVRKSVANNLNDISKTHPHLLRKVADQWYGTH PHTDWIIKHAYRTLLKKGDKQALALFGYENADSIQLHDLTCQPKRIVIGESLEFSFYI HSDRDQKVRIEYAIDFVKARGQRHQKVFKITETNIRKNETKSYTRIQSFKDLTTRKHY KGIHTLSVIINGEVKDSLDFQVC*" /label="yhaZ CDS" gene complement(1004720..1005793) /gene="yhaZ" /locus_tag="BSU_09810" /old_locus_tag="BSU09810" /label="yhaZ gene" downshifts complement(1004827) /Source="Nicolas_upshifts" /id="D523" /incds=1 /nref=16 /ntot=173 /MaxReadThrough="3.78071" /MaxDrop="3.586" /score="4.43596345" /energy="-12.3" /TU="U781" /idTUdmin="U781" /TUdmin="-109" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1005815..1005834) /Source="Nicolas_upshift_promotors" /id="U781" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig=1 /xcortree=2090 /SigmaFactorBS="ggtaggatcagttgttaatttttaggactataCACTTGATcc agaacgtacatTCCCATACAATATAAATAATaaacgaaaaagcggtgtttatatggct g" /listShort="yhaZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1005827) /Source="Nicolas_upshifts" /id="U781" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig=1 /xcortree=2090 /SigmaFactorBS="ggtaggatcagttgttaatttttaggactataCACTTGATcc agaacgtacatTCCCATACAATATAAATAATaaacgaaaaagcggtgtttatatggct g" /listShort="yhaZ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1005848..1005855) /Source="Nicolas_upshift_promotors" /id="U781" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig=1 /xcortree=2090 /SigmaFactorBS="ggtaggatcagttgttaatttttaggactataCACTTGATcc agaacgtacatTCCCATACAATATAAATAATaaacgaaaaagcggtgtttatatggct g" /listShort="yhaZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1005930..1005937 /Source="Nicolas_upshift_promotors" /id="U782" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.882117882117882" /psig=1 /xcortree=344 /SigmaFactorBS="ggatatacaaaagttggttactttttttagttaaaaaaacCC TTGTCAtcggaaaggaaaacTGAGATAATAACATTGAAAGcgcctacacttacctatt t" /listShort="S345, S346, yhaX" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1005950 /Source="Nicolas_upshifts" /id="U782" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.882117882117882" /psig=1 /xcortree=344 /SigmaFactorBS="ggatatacaaaagttggttactttttttagttaaaaaaacCC TTGTCAtcggaaaggaaaacTGAGATAATAACATTGAAAGcgcctacacttacctatt t" /listShort="S345, S346, yhaX" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1005952..1005971 /Source="Nicolas_upshift_promotors" /id="U782" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.882117882117882" /psig=1 /xcortree=344 /SigmaFactorBS="ggatatacaaaagttggttactttttttagttaaaaaaacCC TTGTCAtcggaaaggaaaacTGAGATAATAACATTGAAAGcgcctacacttacctatt t" /listShort="S345, S346, yhaX" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1005961..1006114 /Source="Nicolas_S_feature" /locus_tag="new_1056384_1056537" /HighExp="M9-stat, BC, T0.30H, T1.30H, Lbstat, T1.0H, T3.30H, T2.0H, T3.0H, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S345" downshifts 1006071 /Source="Nicolas_upshifts" /id="D524" /incds=0 /nref=1 /ntot=37 /MaxReadThrough="7.40404" /MaxDrop="2.6506" /score="-6.05745557" /energy="-4.8" /TU="U782" /idTUdmin="U782" /TUdmin="-1056" /isTUend="FALSE" /label="downshifts" S_feature 1006116..1006199 /Source="Nicolas_S_feature" /locus_tag="new_1056539_1056622" /HighExp="M9-stat, B60, T2.0H, T1.30H, T0.30H, T2.30H, T3.0H, T1.0H, Lbtran, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S346" downshifts 1006156 /Source="Nicolas_upshifts" /id="D525" /incds=0 /nref=70 /ntot=231 /MaxReadThrough="4.88371" /MaxDrop="4.4099" /score="-6.05745557" /energy="-4.8" /TU="U782" /idTUdmin="U782" /TUdmin="-971" /isTUend="FALSE" /label="downshifts" promotor_-35 1006212..1006217 /Source="Nicolas_upshift_promotors" /id="U783" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1164 /SigmaFactorBS="gccaggctttttttgctttaagaaaaggttGTTCTAaacaca gagacagggTCATATCCTATACACAAGTacagtcatcaaggagggggacatctctgtg t" /listShort="yhaX, hemZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1006233..1006251 /Source="Nicolas_upshift_promotors" /id="U783" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1164 /SigmaFactorBS="gccaggctttttttgctttaagaaaaggttGTTCTAaacaca gagacagggTCATATCCTATACACAAGTacagtcatcaaggagggggacatctctgtg t" /listShort="yhaX, hemZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1006242 /Source="Nicolas_upshifts" /id="U783" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1164 /SigmaFactorBS="gccaggctttttttgctttaagaaaaggttGTTCTAaacaca gagacagggTCATATCCTATACACAAGTacagtcatcaaggagggggacatctctgtg t" /listShort="yhaX, hemZ" /GFF_Attribute="listLong" /label="upshifts" CDS 1006279..1007145 /gene="yhaX" /locus_tag="BSU_09830" /old_locus_tag="BSU09830" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11988534; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_388864.2" /db_xref="EnsemblGenomes-Gn:BSU09830" /db_xref="EnsemblGenomes-Tr:CAB12822" /db_xref="GOA:O07539" /db_xref="InterPro:IPR000150" /db_xref="InterPro:IPR006379" /db_xref="InterPro:IPR036412" /db_xref="PDB:3DNP" /db_xref="SubtiList:BG13000" /db_xref="UniProtKB/Swiss-Prot:O07539" /translation="MSKQLLALNIDGALLRSNGKIHQATKDAIEYVKKKGIYVTLVTN RHFRSAQKIAKSLKLDAKLITHSGAYIAEKIDAPFFEKRISDDHTFNIVQVLESYQCN IRLLHEKYSIGNKKKVNSNLLGKALIHPSDPIFYPVQFVESLSDLLMDEPVSAPVIEV YTEHDIQHDITETITKAFPAVDVIRVNDEKLNIVPKGVSKEAGLALVASELGLSMDDV VAIGHQYDDLPMIELAGLGVAMGNAVPEIKRKADWVTRSNDEQGVAYMMKEYFRMQQR KGFLDKFHMKRV*" /label="yhaX CDS" gene 1006279..1007145 /gene="yhaX" /locus_tag="BSU_09830" /old_locus_tag="BSU09830" /label="yhaX gene" downshifts 1007127 /Source="Nicolas_upshifts" /id="D526" /incds=0 /nref=22 /ntot=67 /MaxReadThrough="3.99904" /MaxDrop="4.7771" /score="15.7706912" /energy="-16.6" /TU="U783" /idTUdmin="U782" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1007190..1007193 /Source="Nicolas_upshift_promotors" /id="U784" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=1455 /SigmaFactorBS="cgcgccctgacaggtgcggcggcttttttgccggATTGattt tagcagtttaTTTCTGTACACTAAAGAAAGttttgaatctgataaattaggtgatgaa g" /listShort="hemZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1007208..1007227 /Source="Nicolas_upshift_promotors" /id="U784" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=1455 /SigmaFactorBS="cgcgccctgacaggtgcggcggcttttttgccggATTGattt tagcagtttaTTTCTGTACACTAAAGAAAGttttgaatctgataaattaggtgatgaa g" /listShort="hemZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1007216 /Source="Nicolas_upshifts" /id="U784" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=1455 /SigmaFactorBS="cgcgccctgacaggtgcggcggcttttttgccggATTGattt tagcagtttaTTTCTGTACACTAAAGAAAGttttgaatctgataaattaggtgatgaa g" /listShort="hemZ" /GFF_Attribute="listLong" /label="upshifts" CDS 1007257..1008762 /gene="hemZ" /locus_tag="BSU_09840" /old_locus_tag="BSU09840" /EC_number="1.3.99.-" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10498703, 21255303" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10498703, 21255303; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="coproporphyrinogen III oxidase" /protein_id="NP_388865.1" /db_xref="EnsemblGenomes-Gn:BSU09840" /db_xref="EnsemblGenomes-Tr:CAB12823" /db_xref="GOA:Q796V8" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR023995" /db_xref="InterPro:IPR034505" /db_xref="SubtiList:BG12999" /db_xref="UniProtKB/Swiss-Prot:Q796V8" /translation="MQIKIEGIHDDRLHRPLQNIANLFYEECELAYGGEEPADFVISL ALSQTDEHVTVSGEVKGTGIKEQHTKFFSPDMTEKEAFKQVKNTISYVYLNLLQAHTG ITQKWGILTGIRPTKLLHKKLQSGMSKEQAHAELKKDYLIHDEKIMLMQEIVDRQLAA VPDLYRVKDEVSIYIGIPFCPTKCAYCTFPAYAIQGQAGRVGSFLWGLHYEMQKIGEW LKEHDVKVTTIYFGGGTPTSITAEEMDLLYEEMVRSFPDVKNIREITVEAGRPDTITE EKLAVLNKYDIDRISINPQSYENETLKAIGRHHTVEETIEKYHLSRQHGMNNINMDLI IGLPGEGVKEFRHSLSETEKLMPESLTVHTLSFKRASEMTRNKHKYKVAGREEVSQMM EDAVAWTKEHGYVPYYLYRQKNILGNLENVGYSLPGQESIYNIMIMEEVQTIIGIGCG AASKFIDRDTGKITHFANPKDPKSYNERFEHYTDEKIKYLEQIFEKTTKQH*" /label="hemZ CDS" gene 1007257..1008762 /gene="hemZ" /locus_tag="BSU_09840" /old_locus_tag="BSU09840" /label="hemZ gene" downshifts 1008732 /Source="Nicolas_upshifts" /id="D527" /incds=0 /nref=113 /ntot=234 /MaxReadThrough="0.523269999999999" /MaxDrop="5.05369" /score="38.1573779" /energy="-14.4" /TU="NA" /idTUdmin="U783" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1008780..1009997) /gene="khtU" /locus_tag="BSU_09850" /old_locus_tag="BSU09850" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7934942, 14987767, 15849754, 15919996, 16850406, 24330391" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7934942, 14987767, 15849754, 15919996, 16850406, 24330391; Product type t : transporter" /codon_start=1 /transl_table=11 /product="proton/potassium antiporter; methylglyoxal resistance" /protein_id="NP_388866.2" /db_xref="EnsemblGenomes-Gn:BSU09850" /db_xref="EnsemblGenomes-Tr:CAB12825" /db_xref="GOA:O07536" /db_xref="InterPro:IPR006153" /db_xref="SubtiList:BG12997" /db_xref="UniProtKB/Swiss-Prot:O07536" /translation="MDHLVFEVGTALVLVAIASVIANKIKFSIIPFLIVLGMLVGPHA PKMGIIDLTFIQSSEIIEFFGRMGVLFLLFYLGLEFSVGKLIKSGKSIAVGGTIYILI NFSLGLLYGFITGFSFLEVLILAGVITISSSAIVAKVLVDLKRTANPETELILGIIMF EDIFLAVYLSVVSGLILGDATSVGSALLSILIAFGYMLLFFIAARKLPPLLNKLLDIR SNEVFIIVIFAALFFIAGFSETIHVAEAIGALLLGLVFSETEHSDRIEHLVVPFRDFF GAMFFFSFGLSIDPFSLGEAVWLALGAVILTILGNFIAGMVAGRRAGLSHKASSNIGL TIVSRGEFSIIVANLGIAGGLSATLKPFAALYVLILAILGPLVTKESKRIYRLLNKVF KWKPEVQPAKKQG*" /label="khtU CDS" gene complement(1008780..1009997) /gene="khtU" /locus_tag="BSU_09850" /old_locus_tag="BSU09850" /label="khtU gene" downshifts complement(1008786) /Source="Nicolas_upshifts" /id="D528" /incds=0 /nref=154 /ntot=249 /MaxReadThrough="1.74386" /MaxDrop="6.8685" /score="8.64654688" /energy="-14.4" /TU="NA" /idTUdmin="U785" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(1010004..1010501) /gene="khtT" /locus_tag="BSU_09860" /old_locus_tag="BSU09860" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:14987767, 17679694" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14987767, 17679694; Product type t: transporter" /codon_start=1 /transl_table=11 /product="K+/H+ antiporter for K+ efflux" /protein_id="NP_388867.1" /db_xref="EnsemblGenomes-Gn:BSU09860" /db_xref="EnsemblGenomes-Tr:CAB12826" /db_xref="GOA:O07535" /db_xref="InterPro:IPR006037" /db_xref="InterPro:IPR026278" /db_xref="InterPro:IPR036721" /db_xref="SubtiList:BG12996" /db_xref="UniProtKB/Swiss-Prot:O07535" /translation="MNIKENDLPGIGKKFEIETRSHEKMTIIIHDDGRREIYRFNDRD PDELLSNISLDDSEARQIAAILGGMVYKPQALESIEMAFSDLIIEWFKVEKGAKSIGR TLGELDVRQNYDVTVIAIIKHNQEKLLNPGADSIIEENDTLVLSGERKHLKKLIHDFL SGEGV*" /label="khtT CDS" gene complement(1010004..1010501) /gene="khtT" /locus_tag="BSU_09860" /old_locus_tag="BSU09860" /label="khtT gene" CDS complement(1010565..1010903) /gene="khtS" /locus_tag="BSU_09870" /old_locus_tag="BSU09870" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:14987767, 17679694" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14987767, 17679694; Product type t: transporter" /codon_start=1 /transl_table=11 /product="K+/H+ antiporter for K+ efflux" /protein_id="NP_388868.1" /db_xref="EnsemblGenomes-Gn:BSU09870" /db_xref="EnsemblGenomes-Tr:CAB12827" /db_xref="GOA:O07534" /db_xref="SubtiList:BG12995" /db_xref="UniProtKB/Swiss-Prot:O07534" /translation="MRREERNMDKLLISFLLSLFMVYFPPSDVVLPSQFEASTDSYVP MSSYPQETQSAKTPSPGSMHPAELIKEYSPLAQSVRQLSVKPLDEPLINRLEKALAVP VKYQSNYLRI*" /label="khtS CDS" gene complement(1010565..1010903) /gene="khtS" /locus_tag="BSU_09870" /old_locus_tag="BSU09870" /label="khtS gene" promotor_-10 complement(1010915..1010934) /Source="Nicolas_upshift_promotors" /id="U785" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig="0.97902097902098" /xcortree=628 /SigmaFactorBS="acctttttatttttcaaggtcaatagatactgaaaaatgcat atTGTTTGAAtggaaacataaagTTTTATATAGTGAAAAAGAAgggatatcttgatga g" /listShort="khtS, khtT, yhaU" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1010939) /Source="Nicolas_upshifts" /id="U785" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig="0.97902097902098" /xcortree=628 /SigmaFactorBS="acctttttatttttcaaggtcaatagatactgaaaaatgcat atTGTTTGAAtggaaacataaagTTTTATATAGTGAAAAAGAAgggatatcttgatga g" /listShort="khtS, khtT, yhaU" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1010948..1010955) /Source="Nicolas_upshift_promotors" /id="U785" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig="0.97902097902098" /xcortree=628 /SigmaFactorBS="acctttttatttttcaaggtcaatagatactgaaaaatgcat atTGTTTGAAtggaaacataaagTTTTATATAGTGAAAAAGAAgggatatcttgatga g" /listShort="khtS, khtT, yhaU" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1010975..1010982 /Source="Nicolas_upshift_promotors" /id="U786" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.825174825174825" /psig="0.971028971028971" /xcortree=364 /SigmaFactorBS="attcaaacaatatgcatttttcagtatcTATTGACCttgaaa aataaaaaGGTTTATTTGGGGATGGCGGggaatgtataggagaaagaaaaaagtaagc g" /listShort="yhaR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1010997..1011016 /Source="Nicolas_upshift_promotors" /id="U786" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.825174825174825" /psig="0.971028971028971" /xcortree=364 /SigmaFactorBS="attcaaacaatatgcatttttcagtatcTATTGACCttgaaa aataaaaaGGTTTATTTGGGGATGGCGGggaatgtataggagaaagaaaaaagtaagc g" /listShort="yhaR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1011007 /Source="Nicolas_upshifts" /id="U786" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.825174825174825" /psig="0.971028971028971" /xcortree=364 /SigmaFactorBS="attcaaacaatatgcatttttcagtatcTATTGACCttgaaa aataaaaaGGTTTATTTGGGGATGGCGGggaatgtataggagaaagaaaaaagtaagc g" /listShort="yhaR" /GFF_Attribute="listLong" /label="upshifts" CDS 1011068..1011835 /gene="yhaR" /locus_tag="BSU_09880" /old_locus_tag="BSU09880" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22961985; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dehydratase / isomerase" /protein_id="NP_388869.3" /db_xref="EnsemblGenomes-Gn:BSU09880" /db_xref="EnsemblGenomes-Tr:CAB12828" /db_xref="GOA:O07533" /db_xref="InterPro:IPR001753" /db_xref="InterPro:IPR014748" /db_xref="InterPro:IPR029045" /db_xref="SubtiList:BG12994" /db_xref="UniProtKB/Swiss-Prot:O07533" /translation="MEFVQYACNGAVAEIILNRPDAHHALNEQMLSELKEAVEMAAAS EALIVLLRGSGKGFSAGGDIRMMTSEHDPDQFKRLMDTIEAVTLNLYQMKKVTIAAIH GAAAGLGLSLALCADIVLAEKNAVLAMNFIGIGLVPDGGGHYLLKKRIGEAKAKKLIW SGKKLSASEAADMGLLDGTFAGDPAEGARPIIETLLASPLLAMIETKGIFQSLQIEEL KKVLSLERSAQERMRRTKDHQEGIRAFLEKREPKFQA*" /label="yhaR CDS" gene 1011068..1011835 /gene="yhaR" /locus_tag="BSU_09880" /old_locus_tag="BSU09880" /label="yhaR gene" downshifts 1011836 /Source="Nicolas_upshifts" /id="D529" /incds=0 /nref=2 /ntot=99 /MaxReadThrough="1.78111" /MaxDrop="4.66019" /score="-8.79921781" /energy="-7.5" /TU="NA" /idTUdmin="U786" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1011856..1012041) /gene="yhzD" /locus_tag="BSU_09889" /old_locus_tag="BSU09889" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097698.1" /db_xref="EnsemblGenomes-Gn:BSU09889" /db_xref="EnsemblGenomes-Tr:CAX52586" /db_xref="InterPro:IPR025544" /db_xref="UniProtKB/Swiss-Prot:C0H3Y1" /translation="MADYFLTVFDPSGNTLVNEQFEAEHEEAAKTHGEALLKEKELHS HTHRLVNAAGKLILFHR*" /label="yhzD CDS" gene complement(1011856..1012041) /gene="yhzD" /locus_tag="BSU_09889" /old_locus_tag="BSU09889" /label="yhzD gene" promotor_-10 complement(1012077..1012095) /Source="Nicolas_upshift_promotors" /id="U787" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.637362637362637" /psig="0.637362637362637" /xcortree=957 /SigmaFactorBS="acccattatatactaattttggataaagcataatAAAGGATT TtgatttccttTTTAGAATATAAATGAAGAaagactgataaaccttaaaatggaggag a" /listShort="yhzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1012088) /Source="Nicolas_upshifts" /id="U787" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.637362637362637" /psig="0.637362637362637" /xcortree=957 /SigmaFactorBS="acccattatatactaattttggataaagcataatAAAGGATT TtgatttccttTTTAGAATATAAATGAAGAaagactgataaaccttaaaatggaggag a" /listShort="yhzD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1012106..1012114) /Source="Nicolas_upshift_promotors" /id="U787" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.637362637362637" /psig="0.637362637362637" /xcortree=957 /SigmaFactorBS="acccattatatactaattttggataaagcataatAAAGGATT TtgatttccttTTTAGAATATAAATGAAGAaagactgataaaccttaaaatggaggag a" /listShort="yhzD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1012115..1012118 /Source="Nicolas_upshift_promotors" /id="U788" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.797202797202797" /psig="0.974025974025974" /xcortree=2418 /SigmaFactorBS="tttatattctaaaaaggaaatcaaaatcctttATTAtgcttt atccaaaaTTAGTATATAATGGGTCAGGgaaggaggagattcagtgcttacaattgat c" /listShort="natA, natB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1012133..1012152 /Source="Nicolas_upshift_promotors" /id="U788" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.797202797202797" /psig="0.974025974025974" /xcortree=2418 /SigmaFactorBS="tttatattctaaaaaggaaatcaaaatcctttATTAtgcttt atccaaaaTTAGTATATAATGGGTCAGGgaaggaggagattcagtgcttacaattgat c" /listShort="natA, natB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1012143 /Source="Nicolas_upshifts" /id="U788" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.797202797202797" /psig="0.974025974025974" /xcortree=2418 /SigmaFactorBS="tttatattctaaaaaggaaatcaaaatcctttATTAtgcttt atccaaaaTTAGTATATAATGGGTCAGGgaaggaggagattcagtgcttacaattgat c" /listShort="natA, natB" /GFF_Attribute="listLong" /label="upshifts" CDS 1012168..1013064 /gene="yhaQ" /locus_tag="BSU_09890" /old_locus_tag="BSU09890" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9106203, 10356997, 12374817; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Na+-dependent efflux ABC transporter (ATP-binding protein)" /protein_id="NP_388870.2" /db_xref="EnsemblGenomes-Gn:BSU09890" /db_xref="EnsemblGenomes-Tr:CAB12829" /db_xref="GOA:C0SPB4" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR025302" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12993" /db_xref="UniProtKB/Swiss-Prot:C0SPB4" /translation="MLTIDHVTKTFGDYKAVDGLDLDIPEQQMFGLLGANGAGKTTTF RMILGLLSITEGSISWKGRPVNYHISNKIGYLPEERGLYPKMKVRDQLVYLARLKGME KREAVKELGTWLERFNITDYENKKVEELSKGNQQKIQFISAVLHKPELLILDEPFSGL DPVNVELLKEAVISLKNSGVSILFSSHRMEHVEELCENLCILQKGKPVVQGKLKEIKR SFGKKNVTIHSDDDLRFLQSHEGILQWKETADGVKLQIANEDISQEIFAMLQGKGFIR KFELEEPSLHDIFIEKVGAVYE*" /label="yhaQ CDS" gene 1012168..1013064 /gene="yhaQ" /locus_tag="BSU_09890" /old_locus_tag="BSU09890" /label="yhaQ gene" CDS 1013057..1014316 /gene="yhaP" /locus_tag="BSU_09900" /old_locus_tag="BSU09900" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9106203, 10356997, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Na+-dependent exporter (ABC permease)" /protein_id="NP_388871.2" /db_xref="EnsemblGenomes-Gn:BSU09900" /db_xref="EnsemblGenomes-Tr:CAB12830" /db_xref="GOA:O07523" /db_xref="SubtiList:BG12992" /db_xref="UniProtKB/Swiss-Prot:O07523" /translation="MNKFWIMLSHTYKNKIMAKSFIISTVITVLLVLVVTNLESIISL FQGDDAKEKIAVVDETNELYPVFSKQLKAVDTDGDLDVKLSKQSEDEVTKQVKDESLD GMLIIKRDEKGTISGTYKALTISDESTYQTLQQALTQTKTAVGTAELGVSQETISSLY APVTVGQKALKEGAKSEEELGQTVGLVYIMLFVIYFSVIMYASMIAMEVATEKSSRVM EILISSMPPIQQMFAKLLGIGLVGITQLAIIIGAGSLSLKLNQKSETASSVGGFLNLT DVSATTVIYAVIFFLLGYFLYATLAAFLGSVVSRIEDVQQTITPMTLLVVAGFMIAMF GLNAPDAGFITVTSFIPFFTPMIMFLRVGMLDIPFWQAAVGIGITLLTIVILAVIGAR IYKGGVLIYGNSSAFKAIKQALRLAKN*" /label="yhaP CDS" gene 1013057..1014316 /gene="yhaP" /locus_tag="BSU_09900" /old_locus_tag="BSU09900" /label="yhaP gene" downshifts 1014300 /Source="Nicolas_upshifts" /id="D530" /incds=0 /nref=19 /ntot=187 /MaxReadThrough="2.50232" /MaxDrop="3.26822" /score="8.93460501" /energy="-12.8" /TU="NA" /idTUdmin="U788" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1014364..1014371 /Source="Nicolas_upshift_promotors" /id="U789" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.682317682317682" /psig="0.998001998001998" /xcortree=2088 /SigmaFactorBS="cctggggattctcaggctgtttctttattgacagaaCGTGCA TTcgcaagaattcGGTGCTAAAATAAGGGTACTtcatcctggaaaggagcagaatgtt g" /listShort="yhaO, yhaN, yhaM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1014383..1014402 /Source="Nicolas_upshift_promotors" /id="U789" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.682317682317682" /psig="0.998001998001998" /xcortree=2088 /SigmaFactorBS="cctggggattctcaggctgtttctttattgacagaaCGTGCA TTcgcaagaattcGGTGCTAAAATAAGGGTACTtcatcctggaaaggagcagaatgtt g" /listShort="yhaO, yhaN, yhaM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1014388 /Source="Nicolas_upshifts" /id="U789" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.682317682317682" /psig="0.998001998001998" /xcortree=2088 /SigmaFactorBS="cctggggattctcaggctgtttctttattgacagaaCGTGCA TTcgcaagaattcGGTGCTAAAATAAGGGTACTtcatcctggaaaggagcagaatgtt g" /listShort="yhaO, yhaN, yhaM" /GFF_Attribute="listLong" /label="upshifts" CDS 1014423..1015649 /gene="yhaO" /locus_tag="BSU_09910" /old_locus_tag="BSU09910" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative DNA repair exonuclease" /protein_id="NP_388872.1" /db_xref="EnsemblGenomes-Gn:BSU09910" /db_xref="EnsemblGenomes-Tr:CAB12831" /db_xref="GOA:O07522" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR014576" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG12991" /db_xref="UniProtKB/Swiss-Prot:O07522" /translation="MLTDLTFIHAADLHLDSPFYGISHLPEPIFARIKESTFASVRHM IDAAVREHVDFILLAGDLFDEANRSLKAQLFLKKQFERLRECGISVYVIFGNHDHLGG EWTPIEWPENVHIFSSAVPEEKSFFKEGRRIASIYGFSYQARALMENQAARYRRSTDA PFHIGMLHGTLSGSEGHDPYCPFTHDDLVKSGMDYWALGHIHKRQVLSAEHPAVIYPG NTQARHIKETGDKGYYLVHVTNGDISYEFQRAHDVLWEKAAVDVTEAKNMTALFQMVE DTFSKLRKKGSPVCVRLVLQGTAPEWLLEAPKGTLDEFLEALQEQEAEEERFVWPLRL DDETENEANLTNLDPFFGGLFEDIDRSDLSDVLEGLERHPVYRRHADRFSQEEVKEIK EQAQIILKRQLKVLDT*" /label="yhaO CDS" gene 1014423..1015649 /gene="yhaO" /locus_tag="BSU_09910" /old_locus_tag="BSU09910" /label="yhaO gene" downshifts complement(1015124) /Source="Nicolas_upshifts" /id="D531" /incds=1 /nref=1 /ntot=20 /MaxReadThrough="0.0165100000000002" /MaxDrop="3.62411" /score="-5.83060322" /energy="-15.2" /TU="NA" /idTUdmin="U787" /TUdmin="-3300" /isTUend="FALSE" /label="downshifts" CDS 1015654..1018545 /gene="sbcE" /locus_tag="BSU_09920" /old_locus_tag="BSU09920" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16267290, 19906728, 21517913" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16267290, 19906728, 21517913; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATPase involved in DNA double strand break repair and recombination" /protein_id="NP_388873.1" /db_xref="EnsemblGenomes-Gn:BSU09920" /db_xref="EnsemblGenomes-Tr:CAB12832" /db_xref="GOA:O08455" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12990" /db_xref="UniProtKB/Swiss-Prot:O08455" /translation="MTALRIISLHIYQYGKFSNRTFDFSASPVQVIYGLNEAGKTTMM SFIESMLFGFPKTKKYEPKTGGVYGGVLEAEHPEYGVLKIERTKGTAEKLSVYTEKGE VKQGDVLKQLFQGTDRSLYKAIYSFDVFGLQEIHAFNRDKIGEFLLFSSLFGAEAVSK LDSRLTKESERLYKPNGRNPQLNQELETLKQLAVKLKQAEAEEAGYHQLLEEKRTLEA RLAAAETELKETAGHIRMIEGAIERKPLLNEKATLEQVIAEFPEHAGQFPADGLHQLE KYESHLHPKSAQLEALRVKMAELDKQRQKLIPDKELLAKETLIQELSAAFHMYQSWGE QLAAIQAQLRQTSAQTAAGLEQLNKTDENELLNMNTSYDYEWQLQQAVQQYVQARDRK RQLDETFELARQELEDAEKAVRAASSAILENSQRKDKEAALRAYDETQGQHQEQAKLR EQLTFFERQQAKQKKTVIAAGMLFIVLFSLLQQWIPAISFGAALIVYWLVSGKSSSRN SRETRQPMTDISPAEAEMLREALWEDDRNKQHLLTQRAALQQKEAAYERVIQQFEQWE AEMAPSFTQVERFMNELGFKEDPSFLLDAYSLMKDVKKEVKKKHELTIEAGRLKKHRR TFEERVSMLLPVNQSQDISISDALHTLRKNIEREKEIEKQKKEIETDIHYTKEQMLEL EQEIQYFHAQIEQLFAAAAAKDRDAFFAIAAISRQLKDTENKLHHVNAQLQGGYPEEL ELADSNTLSELKDKQFVENERKERLTEEIEQLRSQIALLSVKQEQLEASGMVSDLKLQ TEMQKERVKETAKKWASIQMVKQVIRNKLERHKKIELPRLLETAGEFFRPLTDGNYQT IYFSETDDSIMVMHRDGTVYHAEELSQGTCEQLYTAIRFALAVTRQGESKLPFQLDDS FVHFDQERLKRVLHVLYDLSEGGRQILYFTCHEHVKDAFHSSQIIHLVS*" /label="sbcE CDS" gene 1015654..1018545 /gene="sbcE" /locus_tag="BSU_09920" /old_locus_tag="BSU09920" /label="sbcE gene" promotor_-35 1016935..1016940 /Source="Nicolas_upshift_promotors" /id="U790" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=796 /SigmaFactorBS="tcgtccgcgattcttgaaaacagccaaagaaaaGATAAAgaa gcagctcttagaGCATATGATGAAACACAGGggcagcaccaagagcaagcgaagctca g" /listShort="yhaM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1016956..1016974 /Source="Nicolas_upshift_promotors" /id="U790" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=796 /SigmaFactorBS="tcgtccgcgattcttgaaaacagccaaagaaaaGATAAAgaa gcagctcttagaGCATATGATGAAACACAGGggcagcaccaagagcaagcgaagctca g" /listShort="yhaM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1016962 /Source="Nicolas_upshifts" /id="U790" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=796 /SigmaFactorBS="tcgtccgcgattcttgaaaacagccaaagaaaaGATAAAgaa gcagctcttagaGCATATGATGAAACACAGGggcagcaccaagagcaagcgaagctca g" /listShort="yhaM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1018553..1018558 /Source="Nicolas_upshift_promotors" /id="U791" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.420579420579421" /psig="0.998001998001998" /xcortree=2174 /SigmaFactorBS="atccatttggtgtcataaaagaggtTCTATAgctgaaaatcg gtaTGTGATATACTGGTATTATGtaagatacggagggagctttaatagaatggctaaa g" /listShort="yhaM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1018573..1018592 /Source="Nicolas_upshift_promotors" /id="U791" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.420579420579421" /psig="0.998001998001998" /xcortree=2174 /SigmaFactorBS="atccatttggtgtcataaaagaggtTCTATAgctgaaaatcg gtaTGTGATATACTGGTATTATGtaagatacggagggagctttaatagaatggctaaa g" /listShort="yhaM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1018588 /Source="Nicolas_upshifts" /id="U791" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.420579420579421" /psig="0.998001998001998" /xcortree=2174 /SigmaFactorBS="atccatttggtgtcataaaagaggtTCTATAgctgaaaatcg gtaTGTGATATACTGGTATTATGtaagatacggagggagctttaatagaatggctaaa g" /listShort="yhaM" /GFF_Attribute="listLong" /label="upshifts" CDS 1018619..1019563 /gene="yhaM" /locus_tag="BSU_09930" /old_locus_tag="BSU09930" /EC_number="3.1.-.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12399495, 15805522, 15983136, 16267290, 19553197, 19880604" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12399495, 15805522, 15983136, 16267290, 19553197, 19880604; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="3'-5' exonuclease" /protein_id="NP_388874.1" /db_xref="EnsemblGenomes-Gn:BSU09930" /db_xref="EnsemblGenomes-Tr:CAB12833" /db_xref="GOA:O07521" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR006674" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR020873" /db_xref="SubtiList:BG12989" /db_xref="UniProtKB/Swiss-Prot:O07521" /translation="MAKGIMLHEVGEQVDQYLLIKSSTKGIASNGKPFLTLMLQDQSG DIEAKLWDAKQSDEVTYAPQTIVKVVGDVHHYRGRTQLKLRNIRPVSEQENVNIDDFL ETAPIPKNEMMDTITQYIFEMKNPNIQRITRFLVKKHEAEFMDYPAATKNHHEFVSGL AYHVVSMLNLAKAIADLYPSLDRDLLYAGVILHDLGKVKELSGPVSTSYTVEGNLLGH ISIMVTELSKAAEELQIDSEEVLILQHLILSHHGKAEWGSPKPPMVKEAEILHYIDNL DAKMNMMDRALERVKPGEYTERVFALENRSFYKPTFHK*" /label="yhaM CDS" gene 1018619..1019563 /gene="yhaM" /locus_tag="BSU_09930" /old_locus_tag="BSU09930" /label="yhaM gene" downshifts 1019541 /Source="Nicolas_upshifts" /id="D532" /incds=0 /nref=183 /ntot=261 /MaxReadThrough="3.02818" /MaxDrop="5.88173" /score="6.06919899" /energy="-15.8" /TU="NA" /idTUdmin="U789" /TUdmin=5 /isTUend="TRUE" /label="downshifts" promotor_-35 1019622..1019627 /Source="Nicolas_upshift_promotors" /id="U792" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1159 /SigmaFactorBS="atattcagctcagtcctttttgatgcgtctttcccgCACATA actcgtctcattcccGCATATGGTTAAGAATAAAgaatctatgcaaagggggaggagc c" /listShort="yhaL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1019643..1019661 /Source="Nicolas_upshift_promotors" /id="U792" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1159 /SigmaFactorBS="atattcagctcagtcctttttgatgcgtctttcccgCACATA actcgtctcattcccGCATATGGTTAAGAATAAAgaatctatgcaaagggggaggagc c" /listShort="yhaL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1019646 /Source="Nicolas_upshifts" /id="U792" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1159 /SigmaFactorBS="atattcagctcagtcctttttgatgcgtctttcccgCACATA actcgtctcattcccGCATATGGTTAAGAATAAAgaatctatgcaaagggggaggagc c" /listShort="yhaL" /GFF_Attribute="listLong" /label="upshifts" CDS 1019688..1019900 /gene="yhaL" /locus_tag="BSU_09940" /old_locus_tag="BSU09940" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:14523133" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14523133; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="sporulation factor" /protein_id="NP_388875.1" /db_xref="EnsemblGenomes-Gn:BSU09940" /db_xref="EnsemblGenomes-Tr:CAB12834" /db_xref="GOA:O07520" /db_xref="InterPro:IPR025428" /db_xref="SubtiList:BG12988" /db_xref="UniProtKB/Swiss-Prot:O07520" /translation="MLFFPWWVYLCIVGIIFSAYKLVAAAKEEEKVDQAFIEKEGQIY MERMEKERERRSSQQHEEENQNHSIA*" /label="yhaL CDS" gene 1019688..1019900 /gene="yhaL" /locus_tag="BSU_09940" /old_locus_tag="BSU09940" /label="yhaL gene" downshifts 1019893 /Source="Nicolas_upshifts" /id="D533" /incds=0 /nref=8 /ntot=158 /MaxReadThrough="2.03283" /MaxDrop="6.60832" /score="62.1892984" /energy="-22" /TU="NA" /idTUdmin="U792" /TUdmin=5 /isTUend="TRUE" /label="downshifts" downshifts complement(1019931) /Source="Nicolas_upshifts" /id="D534" /incds=0 /nref=97 /ntot=260 /MaxReadThrough="0.90997" /MaxDrop="9.00938" /score="52.3375501" /energy="-22" /TU="NA" /idTUdmin="U793" /TUdmin=11 /isTUend="TRUE" /label="downshifts" CDS complement(1019941..1020819) /gene="prsA" /locus_tag="BSU_09950" /old_locus_tag="BSU09950" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12634326, 12682299, 14976191, 16516208, 25525259, 26711778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12634326, 12682299, 14976191, 16516208, 25525259, 26711778; Product type lp : lipoprotein" /codon_start=1 /transl_table=11 /product="molecular chaperone lipoprotein" /protein_id="NP_388876.1" /db_xref="EnsemblGenomes-Gn:BSU09950" /db_xref="EnsemblGenomes-Tr:CAB12835" /db_xref="GOA:P24327" /db_xref="InterPro:IPR000297" /db_xref="InterPro:IPR008880" /db_xref="InterPro:IPR023058" /db_xref="InterPro:IPR023059" /db_xref="InterPro:IPR027304" /db_xref="PDB:1ZK6" /db_xref="PDB:4WO7" /db_xref="SubtiList:BG10464" /db_xref="UniProtKB/Swiss-Prot:P24327" /translation="MKKIAIAAITATSILALSACSSGDKEVIAKTDAGDVTKGELYTN MKKTAGASVLTQLVQEKVLDKKYKVSDKEIDNKLKEYKTQLGDQYTALEKQYGKDYLK EQVKYELLTQKAAKDNIKVTDADIKEYWEGLKGKIRASHILVADKKTAEEVEKKLKKG EKFEDLAKEYSTDSSASKGGDLGWFAKEGQMDETFSKAAFKLKTGEVSDPVKTQYGYH IIKKTEERGKYDDMKKELKSEVLEQKLNDNAAVQEAVQKVMKKADIEVKDKDLKDTFN TSSTSNSTSSSSSNSK*" /label="prsA CDS" gene complement(1019941..1020819) /gene="prsA" /locus_tag="BSU_09950" /old_locus_tag="BSU09950" /label="prsA gene" downshifts complement(1020129) /Source="Nicolas_upshifts" /id="D535" /incds=1 /nref=10 /ntot=127 /MaxReadThrough="7.54458" /MaxDrop="3.5906" /score="52.3375501" /energy="-22" /TU="U793" /idTUdmin="U793" /TUdmin="-187" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1020857..1020876) /Source="Nicolas_upshift_promotors" /id="U793" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.565434565434565" /psig="0.996003996003996" /xcortree=1995 /SigmaFactorBS="gtcatcagcaaaagtttgactagacgaatgccctttatttaa aaTCTTTTTAcagaaagccacaaTATGTTATGATACGCATAGGtaatttaatttggaa t" /listShort="prsA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1020881) /Source="Nicolas_upshifts" /id="U793" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.565434565434565" /psig="0.996003996003996" /xcortree=1995 /SigmaFactorBS="gtcatcagcaaaagtttgactagacgaatgccctttatttaa aaTCTTTTTAcagaaagccacaaTATGTTATGATACGCATAGGtaatttaatttggaa t" /listShort="prsA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1020890..1020897) /Source="Nicolas_upshift_promotors" /id="U793" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.565434565434565" /psig="0.996003996003996" /xcortree=1995 /SigmaFactorBS="gtcatcagcaaaagtttgactagacgaatgccctttatttaa aaTCTTTTTAcagaaagccacaaTATGTTATGATACGCATAGGtaatttaatttggaa t" /listShort="prsA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1020917..1020926 /Source="Nicolas_upshift_promotors" /id="U794" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1349 /SigmaFactorBS="tgtggctttctgtaaaaagattttaaataaagggcattcGTC TAGTCAAacttttgctgatGACATACTTATATATTGATCaagaaaaggaggtatgtaa c" /listShort="yhzE, S347, S349" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1020938 /Source="Nicolas_upshifts" /id="U794" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1349 /SigmaFactorBS="tgtggctttctgtaaaaagattttaaataaagggcattcGTC TAGTCAAacttttgctgatGACATACTTATATATTGATCaagaaaaggaggtatgtaa c" /listShort="yhzE, S347, S349" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1020939..1020958 /Source="Nicolas_upshift_promotors" /id="U794" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1349 /SigmaFactorBS="tgtggctttctgtaaaaagattttaaataaagggcattcGTC TAGTCAAacttttgctgatGACATACTTATATATTGATCaagaaaaggaggtatgtaa c" /listShort="yhzE, S347, S349" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1020975..1020989) /Source="Nicolas_upshift_promotors" /id="U795" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=700 /SigmaFactorBS="taagcaaaatgaacagtactacgagcaacgcgaaTCCGTtag agtatCCTCCGCTCATGTTAcatacctccttttcttgatcaatatataagtatgtcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1020976) /Source="Nicolas_upshifts" /id="U795" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=700 /SigmaFactorBS="taagcaaaatgaacagtactacgagcaacgcgaaTCCGTtag agtatCCTCCGCTCATGTTAcatacctccttttcttgatcaatatataagtatgtcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1020979..1021065 /gene="sscA" /locus_tag="BSU_09958" /old_locus_tag="BSU09958" /function="15.7: Sporulation and germination" /experiment="publication(s) with functional evidences, PMID:20156992, 21670523" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20156992, 21670523; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="spore assembly and germination protein" /protein_id="YP_003097699.1" /db_xref="EnsemblGenomes-Gn:BSU09958" /db_xref="EnsemblGenomes-Tr:CAX52587" /db_xref="GOA:C0H3Y2" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/Swiss-Prot:C0H3Y2" /translation="MSGGYSNGFALLVVLFILLIIVGAAYIY*" /label="sscA CDS" gene 1020979..1021065 /gene="sscA" /locus_tag="BSU_09958" /old_locus_tag="BSU09958" /label="sscA gene" promotor_-35 complement(1020998..1021002) /Source="Nicolas_upshift_promotors" /id="U795" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=700 /SigmaFactorBS="taagcaaaatgaacagtactacgagcaacgcgaaTCCGTtag agtatCCTCCGCTCATGTTAcatacctccttttcttgatcaatatataagtatgtcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1021066..1021317 /Source="Nicolas_S_feature" /locus_tag="new_1071489_1071740" /HighExp="S8, S7, S6, BT, G/S, B36, Pyr, S5, B60, Glucon" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba=1 /TUshortSig="SigK" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S347" CDS 1021190..1021276 /gene="sscB" /locus_tag="BSU_09959" /old_locus_tag="BSU09959" /function="15.7: Sporulation and germination" /experiment="publication(s) with functional evidences, PMID:21670523" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21670523; Product type f: factor" /codon_start=1 /transl_table=11 /product="spore and germination protein" /protein_id="YP_009513948.1" /db_xref="EnsemblGenomes-Gn:BSU09959" /db_xref="EnsemblGenomes-Tr:CCQ48595" /db_xref="GOA:L8EBJ6" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/TrEMBL:L8EBJ6" /translation="MGEVFAGGFALLVVLFILLIIIGASWLY*" /label="sscB CDS" gene 1021190..1021276 /gene="sscB" /locus_tag="BSU_09959" /old_locus_tag="BSU09959" /label="sscB gene" downshifts 1021274 /Source="Nicolas_upshifts" /id="D536" /incds=0 /nref=28 /ntot=50 /MaxReadThrough="4.67734" /MaxDrop="4.7906" /score="14.3797211" /energy="-17.6" /TU="U794" /idTUdmin="U794" /TUdmin="-506" /isTUend="FALSE" /label="downshifts" S_feature complement(1021286..1021548) /Source="Nicolas_S_feature" /locus_tag="new_1071709_1071971_c" /HighExp="LBGtran, LBGstat, LPhT, LBGexp, HPh, dia15, T0.30H, dia0, G180, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 0.995" /TUlongSig="SigA" /TUlongPSig="0.989" /label="S348" S_feature 1021319..1021802 /Source="Nicolas_S_feature" /locus_tag="new_1071742_1072225" /HighExp="S8, S6, S7, BT, C30, S5, Pyr, Glucon, G/S, C90" /AntisenseName="yhaJ" /AntisenseCor="-0.22462434208606599" /AntisenseRegPval="-3.7" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S349" downshifts complement(1021329) /Source="Nicolas_upshifts" /id="D537" /incds=0 /nref=153 /ntot=265 /MaxReadThrough="1.32339" /MaxDrop="6.55635" /score="34.7913848" /energy="-17.6" /TU="NA" /idTUdmin="U796" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1021541..1021560) /Source="Nicolas_upshift_promotors" /id="U796" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.58041958041958" /psig="0.999000999001" /xcortree=2759 /SigmaFactorBS="gtgctggtggcgatttttcaatttgcattCTATCTtttttaa taaataTTTGGTAATGTAATATGGGAcagttcagagagagggggaatctcccatcatt t" /listShort="S348" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1021548) /Source="Nicolas_upshifts" /id="U796" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.58041958041958" /psig="0.999000999001" /xcortree=2759 /SigmaFactorBS="gtgctggtggcgatttttcaatttgcattCTATCTtttttaa taaataTTTGGTAATGTAATATGGGAcagttcagagagagggggaatctcccatcatt t" /listShort="S348" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1021550..1021618) /Source="Nicolas_S_feature" /locus_tag="new_1071973_1072041_c" /HighExp="Paraq, G180, C30, LBGexp, Oxctl, G135, Lbexp, Heat, G150, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.29568499999999998" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="SigA" /TUlongPSig="0.989" /label="S350" promotor_-35 complement(1021574..1021579) /Source="Nicolas_upshift_promotors" /id="U796" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.58041958041958" /psig="0.999000999001" /xcortree=2759 /SigmaFactorBS="gtgctggtggcgatttttcaatttgcattCTATCTtttttaa taaataTTTGGTAATGTAATATGGGAcagttcagagagagggggaatctcccatcatt t" /listShort="S348" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1021619..1022137) /gene="yhaJ" /locus_tag="BSU_09965" /old_locus_tag="BSU09965" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16845009, 21670523, 25651892; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane enzyme" /protein_id="NP_388878.2" /db_xref="EnsemblGenomes-Gn:BSU09965" /db_xref="EnsemblGenomes-Tr:CAB12837" /db_xref="GOA:O07518" /db_xref="InterPro:IPR021683" /db_xref="SubtiList:BG12986" /db_xref="UniProtKB/Swiss-Prot:O07518" /translation="MNCWKTINLMKDYGAVRIILTAVCFMILVFISTFLAFELLRPGT SLSDEYVSLFGGLLVVILFVHKVIHVLPIICKKRKIEKKFYILRMRTWKRIPKTTMLI SLVSPFLLITPVLFYAALAFPNHAHYFCMISGIHAGYCLPDFLLALKLIKAPKTAFID QEADGLDILVEK*" /label="yhaJ CDS" gene complement(1021619..1022137) /gene="yhaJ" /locus_tag="BSU_09965" /old_locus_tag="BSU09965" /label="yhaJ gene" promotor_-35 1021924..1021932 /Source="Nicolas_upshift_promotors" /id="U797" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=540 /SigmaFactorBS="ctatttttctttttttgcagatgattgGCAGGACATggatga ctttaTGTACAAATAAAATAACGAcgagcaaaccgccgaataaagatacatattcatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1021944..1021962 /Source="Nicolas_upshift_promotors" /id="U797" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=540 /SigmaFactorBS="ctatttttctttttttgcagatgattgGCAGGACATggatga ctttaTGTACAAATAAAATAACGAcgagcaaaccgccgaataaagatacatattcatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1021957 /Source="Nicolas_upshifts" /id="U797" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=540 /SigmaFactorBS="ctatttttctttttttgcagatgattgGCAGGACATggatga ctttaTGTACAAATAAAATAACGAcgagcaaaccgccgaataaagatacatattcatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1022168..1022187) /Source="Nicolas_upshift_promotors" /id="U798" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.44955044955045" /psig="0.995004995004995" /xcortree=2615 /SigmaFactorBS="aaaaatacctgccggatgatattttttcttaaaaaagCATTG ATtttttctcttgggagGAGTAAATTATTTTGAGATTctattcaagatgtatggaagg a" /listShort="yhaJ, S350, S348" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1022186) /Source="Nicolas_upshifts" /id="U798" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.44955044955045" /psig="0.995004995004995" /xcortree=2615 /SigmaFactorBS="aaaaatacctgccggatgatattttttcttaaaaaagCATTG ATtttttctcttgggagGAGTAAATTATTTTGAGATTctattcaagatgtatggaagg a" /listShort="yhaJ, S350, S348" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1022203..1022209) /Source="Nicolas_upshift_promotors" /id="U798" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.44955044955045" /psig="0.995004995004995" /xcortree=2615 /SigmaFactorBS="aaaaatacctgccggatgatattttttcttaaaaaagCATTG ATtttttctcttgggagGAGTAAATTATTTTGAGATTctattcaagatgtatggaagg a" /listShort="yhaJ, S350, S348" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1022286..1022289 /Source="Nicolas_upshift_promotors" /id="U799" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.671328671328671" /psig="0.999000999001" /xcortree=2221 /SigmaFactorBS="gaaacaagcaaacaaactgcgaaatatggggttagaaCTTTc ttctcagtgaattATCAGCTAAAATAAGATTAAagatagaaagaagtggtgtggatgg a" /listShort="yhaI, S352" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1022304..1022323 /Source="Nicolas_upshift_promotors" /id="U799" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.671328671328671" /psig="0.999000999001" /xcortree=2221 /SigmaFactorBS="gaaacaagcaaacaaactgcgaaatatggggttagaaCTTTc ttctcagtgaattATCAGCTAAAATAAGATTAAagatagaaagaagtggtgtggatgg a" /listShort="yhaI, S352" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1022309 /Source="Nicolas_upshifts" /id="U799" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.671328671328671" /psig="0.999000999001" /xcortree=2221 /SigmaFactorBS="gaaacaagcaaacaaactgcgaaatatggggttagaaCTTTc ttctcagtgaattATCAGCTAAAATAAGATTAAagatagaaagaagtggtgtggatgg a" /listShort="yhaI, S352" /GFF_Attribute="listLong" /label="upshifts" CDS 1022345..1022686 /gene="yhaI" /locus_tag="BSU_09980" /old_locus_tag="BSU09980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388879.1" /db_xref="EnsemblGenomes-Gn:BSU09980" /db_xref="EnsemblGenomes-Tr:CAB12838" /db_xref="InterPro:IPR015058" /db_xref="InterPro:IPR035945" /db_xref="PDB:1SED" /db_xref="SubtiList:BG12985" /db_xref="UniProtKB/Swiss-Prot:O07517" /translation="MDSMDHRIERLEYYIQLLVKTVDMDRYPFYALLIDKGLSKEEGE AVMRICDELSEELATQKAQGFVTFDKLLALFAGQLNEKLDVHETIFALYEQGLYQELM EVFIDIMKHFD*" /label="yhaI CDS" gene 1022345..1022686 /gene="yhaI" /locus_tag="BSU_09980" /old_locus_tag="BSU09980" /label="yhaI gene" S_feature complement(1022540..1022682) /Source="Nicolas_S_feature" /locus_tag="new_1072963_1073105_c" /HighExp="BC, S1, Sw, S2, S3, S8, S5, S4, S6, S7" /AntisenseName="yhaI" /AntisenseCor="5.4889858269512502E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S351" downshifts complement(1022583) /Source="Nicolas_upshifts" /id="D538" /incds=1 /nref=39 /ntot=209 /MaxReadThrough="2.89899" /MaxDrop="4.77791" /score="-6.0983333" /energy="-12.3" /TU="U801" /idTUdmin="U801" /TUdmin="-374" /isTUend="FALSE" /label="downshifts" CDS complement(1022683..1023294) /gene="scoC" /locus_tag="BSU_09990" /old_locus_tag="BSU09990" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14629015, 15126467, 16321961, 16923912, 19801406, 20382764, 23660663, 25966844, 26473603, 26728191, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14629015, 15126467, 16321961, 16923912, 19801406, 20382764, 23660663, 25966844, 26473603, 26728191, 22720735; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of extracellular protease production, sporulation and bacilysin production (MarR family)" /protein_id="NP_388880.1" /db_xref="EnsemblGenomes-Gn:BSU09990" /db_xref="EnsemblGenomes-Tr:CAB12839" /db_xref="GOA:P11065" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR023488" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2FXA" /db_xref="SubtiList:BG10659" /db_xref="UniProtKB/Swiss-Prot:P11065" /translation="MNRVEPPYDVKEALVFTQKMAQLSKALWKSIEKDWQQWLKPYDL NINEHHILWIAYQLNGASISEIAKFGVMHVSTAFNFSKKLEERGYLRFSKRLNDKRNT YVQLTEEGTEVFWSLLEEFDPTRNAVFKGSQPLYHLFGKFPEVAEMMCMIRHIYGDDF MEIFETSLTNIDNDFESVNGKLKKKAKDSAADEPAEELEPVNS*" /label="scoC CDS" gene complement(1022683..1023294) /gene="scoC" /locus_tag="BSU_09990" /old_locus_tag="BSU09990" /label="scoC gene" S_feature 1022687..1023452 /Source="Nicolas_S_feature" /locus_tag="new_1073110_1073875" /HighExp="Lbstat, Etha, T0.30H, Gly, M0t90, M40t90, M40t45, M0t45, H2O2, dia15" /AntisenseName="scoC" /AntisenseCor="-0.46322626361720198" /AntisenseRegPval="-15" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S352" downshifts complement(1022759) /Source="Nicolas_upshifts" /id="D539" /incds=1 /nref=1 /ntot=81 /MaxReadThrough="5.81117" /MaxDrop="2.1632" /score="-6.0983333" /energy="-12.3" /TU="U801" /idTUdmin="U801" /TUdmin="-550" /isTUend="FALSE" /label="downshifts" promotor_-35 1023290..1023294 /Source="Nicolas_upshift_promotors" /id="U800" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.632367632367632" /psig="0.177822177822178" /xcortree=3100 /SigmaFactorBS="agagcttctttcacatcatagggcggttccactcgaTTCATt acgtcaCCTGCTTCTCTTTTtctttttctctattatgccaataaaataaagattaata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1023302..1023315 /Source="Nicolas_upshift_promotors" /id="U800" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.632367632367632" /psig="0.177822177822178" /xcortree=3100 /SigmaFactorBS="agagcttctttcacatcatagggcggttccactcgaTTCATt acgtcaCCTGCTTCTCTTTTtctttttctctattatgccaataaaataaagattaata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1023314 /Source="Nicolas_upshifts" /id="U800" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.632367632367632" /psig="0.177822177822178" /xcortree=3100 /SigmaFactorBS="agagcttctttcacatcatagggcggttccactcgaTTCATt acgtcaCCTGCTTCTCTTTTtctttttctctattatgccaataaaataaagattaata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1023319..1023338) /Source="Nicolas_upshift_promotors" /id="U801" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.656343656343656" /psig="0.98901098901099" /xcortree=2944 /SigmaFactorBS="cgtcgcaatggtttgtgaatttattaaaaaattcttacattt tcatCTTTattaatctttatttTATTGGCATAATAGAGAAAAagaaaaagagaagcag g" /listShort="scoC, S351" /listLong="yhaJ, S350, S348" /label="promotor_-10" upshifts complement(1023342) /Source="Nicolas_upshifts" /id="U801" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.656343656343656" /psig="0.98901098901099" /xcortree=2944 /SigmaFactorBS="cgtcgcaatggtttgtgaatttattaaaaaattcttacattt tcatCTTTattaatctttatttTATTGGCATAATAGAGAAAAagaaaaagagaagcag g" /listShort="scoC, S351" /listLong="yhaJ, S350, S348" /label="upshifts" promotor_-35 complement(1023353..1023356) /Source="Nicolas_upshift_promotors" /id="U801" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.656343656343656" /psig="0.98901098901099" /xcortree=2944 /SigmaFactorBS="cgtcgcaatggtttgtgaatttattaaaaaattcttacattt tcatCTTTattaatctttatttTATTGGCATAATAGAGAAAAagaaaaagagaagcag g" /listShort="scoC, S351" /listLong="yhaJ, S350, S348" /label="promotor_-35" downshifts 1023409 /Source="Nicolas_upshifts" /id="D540" /incds=0 /nref=1 /ntot=124 /MaxReadThrough="3.007" /MaxDrop="2.86547" /score="17.8486533" /energy="-7.1" /TU="U799,U800" /idTUdmin="U799" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(1023472..1023828) /gene="yhaH" /locus_tag="BSU_10000" /old_locus_tag="BSU10000" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11429463; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein; acid tolerance protein" /protein_id="NP_388881.1" /db_xref="EnsemblGenomes-Gn:BSU10000" /db_xref="EnsemblGenomes-Tr:CAB12840" /db_xref="GOA:O07516" /db_xref="InterPro:IPR024623" /db_xref="InterPro:IPR036191" /db_xref="SubtiList:BG12984" /db_xref="UniProtKB/Swiss-Prot:O07516" /translation="MASGRSLLTGLFVGGIIGGAAVLLTAPSSGKQLREKMKTNYDSF EETIKRLKSDGLALKDQLIKAAKESTDVIKDVGGELQTSIKKWQEEIKPHQQDLQKEI ADIEEKIRQLEKTLQN*" /label="yhaH CDS" gene complement(1023472..1023828) /gene="yhaH" /locus_tag="BSU_10000" /old_locus_tag="BSU10000" /label="yhaH gene" downshifts complement(1023476) /Source="Nicolas_upshifts" /id="D541" /incds=0 /nref=254 /ntot=287 /MaxReadThrough="1.65317" /MaxDrop="7.37381" /score="10.8990112" /energy="-7.9" /TU="NA" /idTUdmin="U804" /TUdmin=9 /isTUend="TRUE" /label="downshifts" promotor_-35 1023905..1023910 /Source="Nicolas_upshift_promotors" /id="U803" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1168 /SigmaFactorBS="ttcagcatttttcatttttgttgaaagcctgaacttctaTAC ATAgcttgctttattttaGCATATTTTTTAAGTGAAAaggagggagaaggttgtctgt c" /listShort="yhzF, S354" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1023911..1023930) /Source="Nicolas_upshift_promotors" /id="U802" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=1914 /SigmaFactorBS="aggataatacaatcaaaaagacagacaaccttctccctcctt ttcacttaaaaaaTATGCTAAAATAAAGCAAGCtatgtatagaagttcaggctttcaa c" /listShort="yhaH" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1023925) /Source="Nicolas_upshifts" /id="U802" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=1914 /SigmaFactorBS="aggataatacaatcaaaaagacagacaaccttctccctcctt ttcacttaaaaaaTATGCTAAAATAAAGCAAGCtatgtatagaagttcaggctttcaa c" /listShort="yhaH" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1023926..1023944 /Source="Nicolas_upshift_promotors" /id="U803" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1168 /SigmaFactorBS="ttcagcatttttcatttttgttgaaagcctgaacttctaTAC ATAgcttgctttattttaGCATATTTTTTAAGTGAAAaggagggagaaggttgtctgt c" /listShort="yhzF, S354" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1023926 /Source="Nicolas_upshifts" /id="U803" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1168 /SigmaFactorBS="ttcagcatttttcatttttgttgaaagcctgaacttctaTAC ATAgcttgctttattttaGCATATTTTTTAAGTGAAAaggagggagaaggttgtctgt c" /listShort="yhzF, S354" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1023927..1024190) /Source="Nicolas_S_feature" /locus_tag="new_1074350_1074613_c" /HighExp="Etha, Salt, HiTm, Heat, Diami, Sw, Gly, S1, MG 10, MG 60" /AntisenseName="yhzF" /AntisenseCor="-0.69425315975357205" /AntisenseRegPval="-39.299999999999997" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.969, 0.962, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S353" CDS 1023958..1024149 /gene="yhzF" /locus_tag="BSU_10009" /old_locus_tag="BSU10009" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="membrane protein of unknown function" /protein_id="YP_003097700.1" /db_xref="EnsemblGenomes-Gn:BSU10009" /db_xref="EnsemblGenomes-Tr:CAX52588" /db_xref="GOA:C0H3Y3" /db_xref="UniProtKB/Swiss-Prot:C0H3Y3" /translation="MSVFLIVLSCITLAFASGAVYYIKLLSQAASYPPKRVIRQKALV CSTGTAFTLCLIFFTKLLA*" /label="yhzF CDS" gene 1023958..1024149 /gene="yhzF" /locus_tag="BSU_10009" /old_locus_tag="BSU10009" /label="yhzF gene" S_feature 1024150..1025585 /Source="Nicolas_S_feature" /locus_tag="new_1074573_1076008" /HighExp="S3, S8, S4, S6, S7, T5.0H, C30, S5, T4.0H, T3.30H" /AntisenseName="trpP" /AntisenseCor="-0.20038256384636899" /AntisenseRegPval="-3" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S354" CDS complement(1024223..1024741) /gene="trpP" /locus_tag="BSU_10010" /old_locus_tag="BSU10010" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10735881, 14702295, 15849754, 16850406, 16879415, 17114263" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10735881, 14702295, 15849754, 16850406, 16879415, 17114263; Product type t : transporter" /codon_start=1 /transl_table=11 /product="tryptophan transporter or sensor" /protein_id="NP_388882.2" /db_xref="EnsemblGenomes-Gn:BSU10010" /db_xref="EnsemblGenomes-Tr:CAB12841" /db_xref="GOA:O07515" /db_xref="InterPro:IPR031360" /db_xref="SubtiList:BG12983" /db_xref="UniProtKB/Swiss-Prot:O07515" /translation="MKTKELVIMALFAAIGAALHSIIPPFLGGMKPDMMLIMMFMGIL LFPRVQNVLVIGIVTGIISALTTAFPAGQIPNIIDKPVSAFLFFSLFLLFRKSRKTGA AAVLTVIGTILSGIVFLSSALLIVGLPGGFAALFAAVVLPAAVLNTISMIIIYPIVQT ILRRSSFMEAAK*" /label="trpP CDS" gene complement(1024223..1024741) /gene="trpP" /locus_tag="BSU_10010" /old_locus_tag="BSU10010" /label="trpP gene" downshifts complement(1024235) /Source="Nicolas_upshifts" /id="D542" /incds=0 /nref=105 /ntot=253 /MaxReadThrough="6.00956" /MaxDrop="4.62812" /score="24.5949542" /energy="-12.8" /TU="U804,U805,U806" /idTUdmin="U804" /TUdmin="-750" /isTUend="FALSE" /label="downshifts" S_feature complement(1024742..1024829) /Source="Nicolas_S_feature" /locus_tag="new_1075165_1075252_c" /HighExp="C90, B60, S1, GM 15, MG 45, MG-0.2, Etha, Lbtran, MG 25, MG t5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.969, 0.962, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S355" promotor_-10 complement(1024821..1024840) /Source="Nicolas_upshift_promotors" /id="U804" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.541458541458541" /psig="0.969030969030969" /xcortree=591 /SigmaFactorBS="aaattccagcaggaaaatgagtaaaaagTCTGGCTAtgcaaa ccgtccgTTTGGTATACTGTTTGCATAacacattctgtaaagccttcgcaataaatga t" /listShort="S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1024829) /Source="Nicolas_upshifts" /id="U804" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.541458541458541" /psig="0.969030969030969" /xcortree=591 /SigmaFactorBS="aaattccagcaggaaaatgagtaaaaagTCTGGCTAtgcaaa ccgtccgTTTGGTATACTGTTTGCATAacacattctgtaaagccttcgcaataaatga t" /listShort="S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1024854..1024861) /Source="Nicolas_upshift_promotors" /id="U804" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.541458541458541" /psig="0.969030969030969" /xcortree=591 /SigmaFactorBS="aaattccagcaggaaaatgagtaaaaagTCTGGCTAtgcaaa ccgtccgTTTGGTATACTGTTTGCATAacacattctgtaaagccttcgcaataaatga t" /listShort="S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1024866..1025945) /gene="serC" /locus_tag="BSU_10020" /old_locus_tag="BSU10020" /EC_number="2.6.1.52" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:4337849, 16233211" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4337849, 16233211; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoserine aminotransferase" /protein_id="NP_388883.1" /db_xref="EnsemblGenomes-Gn:BSU10020" /db_xref="EnsemblGenomes-Tr:CAB12842" /db_xref="GOA:P80862" /db_xref="InterPro:IPR000192" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR020578" /db_xref="InterPro:IPR022278" /db_xref="SubtiList:BG12673" /db_xref="UniProtKB/Swiss-Prot:P80862" /translation="MERTTNFNAGPAALPLEVLQKAQKEFIDFNESGMSVMELSHRSK EYEAVHQKAKSLLIELMGIPEDYDILFLQGGASLQFSMLPMNFLTPEKTAHFVMTGAW SEKALAETKLFGNTSITATSETDNYSYIPEVDLTDVKDGAYLHITSNNTIFGTQWQEF PNSPIPLVADMSSDILSRKIDVSKFDVIYGGAQKNLGPSGVTVVIMKKSWLQNENANV PKILKYSTHVKADSLYNTPPTFAIYMLSLVLEWLKENGGVEAVEQRNEQKAQVLYSCI DESNGFYKGHARKDSRSRMNVTFTLRDDELTKTFVQKAKDAKMIGLGGHRSVGGCRAS IYNAVSLEDCEKLAAFMKKFQQENE*" /label="serC CDS" gene complement(1024866..1025945) /gene="serC" /locus_tag="BSU_10020" /old_locus_tag="BSU10020" /label="serC gene" misc_feature complement(1025984..1026003) /Source="Nicolas_upshift_promotors" /id="U805" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.772227772227772" /psig="0.962037962037962" /xcortree=3059 /SigmaFactorBS="atccgtcaatttcttttgataattctaattttttatcaaaaa actgaattttTGTGATAGGATAATTGTATTattttatacattaacgtggaaaacaggg a" /listShort="serC, S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1025995) /Source="Nicolas_upshifts" /id="U805" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.772227772227772" /psig="0.962037962037962" /xcortree=3059 /SigmaFactorBS="atccgtcaatttcttttgataattctaattttttatcaaaaa actgaattttTGTGATAGGATAATTGTATTattttatacattaacgtggaaaacaggg a" /listShort="serC, S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1025997..1026078) /Source="Nicolas_S_feature" /locus_tag="new_1076420_1076501_c" /HighExp="Etha, dia15, H2O2, LBGtran, G135, G180, dia5, G150, Lbexp, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S356" CDS complement(1026092..1026529) /gene="hinT" /locus_tag="BSU_10030" /old_locus_tag="BSU10030" /EC_number="3.6.1.29" /EC_number="3.6.1.-" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9579061, 15703176, 16934294, 17217311, 26181368, 28516732; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="promiscuous Hit-family phosphohydrolase, adenosine phosphoramidase" /protein_id="NP_388884.1" /db_xref="EnsemblGenomes-Gn:BSU10030" /db_xref="EnsemblGenomes-Tr:CAB12843" /db_xref="GOA:O07513" /db_xref="InterPro:IPR001310" /db_xref="InterPro:IPR011146" /db_xref="InterPro:IPR019808" /db_xref="InterPro:IPR036265" /db_xref="PDB:1Y23" /db_xref="SubtiList:BG12607" /db_xref="UniProtKB/Swiss-Prot:O07513" /translation="MHCAENCIFCKIIAGDIPSAKVYEDEHVLAFLDISQVTKGHTLV IPKTHIENVYEFTDELAKQYFHAVPKIARAIRDEFEPIGLNTLNNNGEKAGQSVFHYH MHIIPRYGKGDGFGAVWKTHADDYKPEDLQNISSSIAKRLASS*" /label="hinT CDS" gene complement(1026092..1026529) /gene="hinT" /locus_tag="BSU_10030" /old_locus_tag="BSU10030" /label="hinT gene" downshifts complement(1026123) /Source="Nicolas_upshifts" /id="D543" /incds=0 /nref=187 /ntot=248 /MaxReadThrough="4.31506" /MaxDrop="5.61862" /score="-0.366845751" /energy="-8.6" /TU="U806" /idTUdmin="U807" /TUdmin=4 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1026562..1026581) /Source="Nicolas_upshift_promotors" /id="U806" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2360 /SigmaFactorBS="tctgcattcagggtgaacgctcgccgttcatcctGTTTTCTA ttttctgcatttcTGTGGTACGATGAATGTATAcatactaaacaatttcataaggagg a" /listShort="hinT, S356, serC, S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1026576) /Source="Nicolas_upshifts" /id="U806" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2360 /SigmaFactorBS="tctgcattcagggtgaacgctcgccgttcatcctGTTTTCTA ttttctgcatttcTGTGGTACGATGAATGTATAcatactaaacaatttcataaggagg a" /listShort="hinT, S356, serC, S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="upshifts" downshifts 1026579 /Source="Nicolas_upshifts" /id="D544" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="2.3752" /MaxDrop="3.02008" /score="-3.56654132" /energy="-13.3" /TU="NA" /idTUdmin="U803" /TUdmin=1034 /isTUend="FALSE" /label="downshifts" promotor_-35 complement(1026595..1026602) /Source="Nicolas_upshift_promotors" /id="U806" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2360 /SigmaFactorBS="tctgcattcagggtgaacgctcgccgttcatcctGTTTTCTA ttttctgcatttcTGTGGTACGATGAATGTATAcatactaaacaatttcataaggagg a" /listShort="hinT, S356, serC, S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1026601..1026897) /Source="Nicolas_S_feature" /locus_tag="new_1077024_1077320_c" /HighExp="S7, S8, S6, S5, BT, ferm, nit, G/S, S4, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S357" downshifts complement(1026644) /Source="Nicolas_upshifts" /id="D545" /incds=0 /nref=40 /ntot=72 /MaxReadThrough="3.07347" /MaxDrop="7.69075" /score="9.88617558" /energy="-14.2" /TU="U807" /idTUdmin="U807" /TUdmin="-517" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1026895..1026906) /Source="Nicolas_upshift_promotors" /id="U807" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=832 /SigmaFactorBS="aaacaattcccttttaacaaatgatgaatttgctGTCATAAa gagacagggttctGGACATCATAAAagttgtagaggaaaagcatatcaactgaaaaat g" /listShort="S357, hinT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1026901) /Source="Nicolas_upshifts" /id="U807" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=832 /SigmaFactorBS="aaacaattcccttttaacaaatgatgaatttgctGTCATAAa gagacagggttctGGACATCATAAAagttgtagaggaaaagcatatcaactgaaaaat g" /listShort="S357, hinT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1026921..1026927) /Source="Nicolas_upshift_promotors" /id="U807" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=832 /SigmaFactorBS="aaacaattcccttttaacaaatgatgaatttgctGTCATAAa gagacagggttctGGACATCATAAAagttgtagaggaaaagcatatcaactgaaaaat g" /listShort="S357, hinT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1026957..1026964 /Source="Nicolas_upshift_promotors" /id="U808" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.553446553446553" /psig=1 /xcortree=1921 /SigmaFactorBS="cagcaaattcatcatttgttaaaagggaatTGTTTCAAatca ggccttgttTTTGGTACTATGAAGAAAAAcactataaggggagaaactatgtctctgc t" /listShort="ecsA, ecsB, ecsC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1026978..1026997 /Source="Nicolas_upshift_promotors" /id="U808" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.553446553446553" /psig=1 /xcortree=1921 /SigmaFactorBS="cagcaaattcatcatttgttaaaagggaatTGTTTCAAatca ggccttgttTTTGGTACTATGAAGAAAAAcactataaggggagaaactatgtctctgc t" /listShort="ecsA, ecsB, ecsC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1026987 /Source="Nicolas_upshifts" /id="U808" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.553446553446553" /psig=1 /xcortree=1921 /SigmaFactorBS="cagcaaattcatcatttgttaaaagggaatTGTTTCAAatca ggccttgttTTTGGTACTATGAAGAAAAAcactataaggggagaaactatgtctctgc t" /listShort="ecsA, ecsB, ecsC" /GFF_Attribute="listLong" /label="upshifts" CDS 1027017..1027760 /gene="ecsA" /locus_tag="BSU_10040" /old_locus_tag="BSU10040" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8581172, 10027970, 11807061, 18599827, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8581172, 10027970, 11807061, 18599827, 26735940; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (ATP-binding protein)" /protein_id="NP_388885.1" /db_xref="EnsemblGenomes-Gn:BSU10040" /db_xref="EnsemblGenomes-Tr:CAB12844" /db_xref="GOA:P55339" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11516" /db_xref="UniProtKB/Swiss-Prot:P55339" /translation="MSLLSVKDLTGGYTRNPVLKNVSFTLEPNQIVGLIGLNGAGKST TIRHIIGLMDPHKGSIELNGKTFAEDPEGYRSQFTYIPETPVLYEELTLMEHLELTAM AYGLSKETMEKRLPPLLKEFRMEKRLKWFPAHFSKGMKQKVMIMCAFLAEPALYIIDE PFLGLDPLAINALLERMNEAKKGGASVLMSTHILATAERYCDSFIILHNGEVRARGTL SELREQFGMKDAALDDLYLELTKEDAGHE*" /label="ecsA CDS" gene 1027017..1027760 /gene="ecsA" /locus_tag="BSU_10040" /old_locus_tag="BSU10040" /label="ecsA gene" CDS 1027753..1028979 /gene="ecsB" /locus_tag="BSU_10050" /old_locus_tag="BSU10050" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8581172, 10027970, 15175311, 15849754, 16850406, 18599827, 21665535, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8581172, 10027970, 15175311, 15849754, 16850406, 18599827, 21665535, 26735940; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (permease subunit)" /protein_id="NP_388886.1" /db_xref="EnsemblGenomes-Gn:BSU10050" /db_xref="EnsemblGenomes-Tr:CAB12845" /db_xref="GOA:P55340" /db_xref="InterPro:IPR010288" /db_xref="SubtiList:BG11517" /db_xref="UniProtKB/Swiss-Prot:P55340" /translation="MNNMLDIWQSRLQEHIKETRTYMKYMLNDHLVIVLIFFLAGAAS WYSKWIRDIPAHFPSFWVMAVLFSLVLTSSYVRTLLKEADLVFLLPLEAKMEPYLKQA FVYSYVSQLFPLIALSIVAMPLYFAVTPGASLVSYAAVFVQLLLLKAWNQVMEWRTTF QNDRSMKRMDVIIRFAANTLVLYFVFQSVYMYALLVYVIMAVLYLYMSSAAKRKTFKW ESHIESELRRKQRFYRIANLFTDVPHLRKQAKRRAYLDFLLRLVPFEQRKTFAYMFTR AFLRSSDYLGILVRLTIVFALIIMYVSASPLIAAVLTVFAIFITGIQLLPLFGHFDHL ALQELYPVQKETKLKSYFSLLKTALSIQALLMSVASAYAAGLTGFLYALIGSAVLIFV VLPAYMTTRLKKHGKL*" /label="ecsB CDS" gene 1027753..1028979 /gene="ecsB" /locus_tag="BSU_10050" /old_locus_tag="BSU10050" /label="ecsB gene" promotor_-10 complement(1028312..1028330) /Source="Nicolas_upshift_promotors" /id="U809" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1033 /SigmaFactorBS="tttgctgcggaagacatatacagataaagaacagccATAATG acatagacgagaagcGCATACATATAAACAGATTggaaaacaaaataaagaacgagtg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1028327) /Source="Nicolas_upshifts" /id="U809" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1033 /SigmaFactorBS="tttgctgcggaagacatatacagataaagaacagccATAATG acatagacgagaagcGCATACATATAAACAGATTggaaaacaaaataaagaacgagtg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1028346..1028351) /Source="Nicolas_upshift_promotors" /id="U809" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1033 /SigmaFactorBS="tttgctgcggaagacatatacagataaagaacagccATAATG acatagacgagaagcGCATACATATAAACAGATTggaaaacaaaataaagaacgagtg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1028999..1029709 /gene="ecsC" /locus_tag="BSU_10060" /old_locus_tag="BSU10060" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8581172, 10027970; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_388887.1" /db_xref="EnsemblGenomes-Gn:BSU10060" /db_xref="EnsemblGenomes-Tr:CAB12846" /db_xref="InterPro:IPR024787" /db_xref="SubtiList:BG11518" /db_xref="UniProtKB/Swiss-Prot:P55341" /translation="MTDNQLLMQEALEWKMHFLRKDSMFERFSKRVQTKVNERIPEKI HTVVTESVKKMVEATMAGSNIITYKKDTSALSLSEKNELAKKTIVSYQKVAAAEGVGT GAGGIFLSIADFPLLLSIKMKCLFTLSSIYGFDVKDAQERIFLLLVFQLAFSSDDGRK SLFSVIENWETEKKSIDWRVFQQEYRDYIDVVKLFQLLPGVGAAVGGIANYKLLAQLG ETARHVFHLRILKETAGE*" /label="ecsC CDS" gene 1028999..1029709 /gene="ecsC" /locus_tag="BSU_10060" /old_locus_tag="BSU10060" /label="ecsC gene" downshifts 1029673 /Source="Nicolas_upshifts" /id="D546" /incds=0 /nref=78 /ntot=231 /MaxReadThrough="1.36097" /MaxDrop="4.78417" /score="28.5337351" /energy="-14.6" /TU="NA" /idTUdmin="U808" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" CDS complement(1029727..1030917) /gene="sndC" /locus_tag="BSU_10070" /old_locus_tag="BSU10070" /EC_number="3.5.1.-" /experiment="publication(s) with functional evidences, PMID:23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetyl amino acid acetylase, promiscuous activity" /protein_id="NP_388888.2" /db_xref="EnsemblGenomes-Gn:BSU10070" /db_xref="EnsemblGenomes-Tr:CAB12847" /db_xref="GOA:O07598" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR017439" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG12982" /db_xref="UniProtKB/Swiss-Prot:O07598" /translation="MSISTLQKEINKQLDGCFEEMVEIRRHFHMYPELSFQEEKTAAF IASYYESLGVPIRTNVGGRGVLANIEGSEPGPTVALRADFDALPIQDEKDVPYASKVP GVMHACGHDGHTAALLAVAKVLHQNRHELKGTFVMIHQHAEEYYPGGAKPMIDDGCLE NTDVIFGTHLWATEPLGTILCRPGAVMAAADRFTIKVFGKGGHGAHPHDTKDAVLIGS QIVSSLQHIVSRKVNPIQSAVISTGSFIADNPFNVIADQAVLIGTARSFDENVRDILE KEIEAVVKGICSMHGASYEYTYEQGYPAVVNHPAETNHLVSTAKNTEGVQQVIDGEPQ MGGEDFAYYLQNVKGTFFFTGAAPEQPERVYSHHHPKFDINEKAMLTAAKVLAGAAIT YHQL*" /label="sndC CDS" gene complement(1029727..1030917) /gene="sndC" /locus_tag="BSU_10070" /old_locus_tag="BSU10070" /label="sndC gene" downshifts complement(1029737) /Source="Nicolas_upshifts" /id="D547" /incds=0 /nref=11 /ntot=162 /MaxReadThrough="3.12546" /MaxDrop="4.15559" /score="-4.78420642" /energy="-14.6" /TU="U810" /idTUdmin="U811" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" downshifts complement(1029802) /Source="Nicolas_upshifts" /id="D548" /incds=1 /nref=25 /ntot=206 /MaxReadThrough="4.92378" /MaxDrop="3.21645" /score="-4.78420642" /energy="-14.6" /TU="U810,U811" /idTUdmin="U811" /TUdmin="-67" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1030941..1030960) /Source="Nicolas_upshift_promotors" /id="U810" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.498501498501498" /psig=1 /xcortree=2900 /SigmaFactorBS="gtgacaaccctcgcagctgtgatgatgctttaaaacagcatg aGTTGAAatattcagactttTTCTATACAATCATGGAAAAgcatagaaaagggggaag c" /listShort="yhaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1030962) /Source="Nicolas_upshifts" /id="U810" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.498501498501498" /psig=1 /xcortree=2900 /SigmaFactorBS="gtgacaaccctcgcagctgtgatgatgctttaaaacagcatg aGTTGAAatattcagactttTTCTATACAATCATGGAAAAgcatagaaaagggggaag c" /listShort="yhaA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1030974..1030979) /Source="Nicolas_upshift_promotors" /id="U810" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.498501498501498" /psig=1 /xcortree=2900 /SigmaFactorBS="gtgacaaccctcgcagctgtgatgatgctttaaaacagcatg aGTTGAAatattcagactttTTCTATACAATCATGGAAAAgcatagaaaagggggaag c" /listShort="yhaA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1030990..1032381) /gene="yhfA" /locus_tag="BSU_10080" /old_locus_tag="BSU10080" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 12107147; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_388889.1" /db_xref="EnsemblGenomes-Gn:BSU10080" /db_xref="EnsemblGenomes-Tr:CAB12848" /db_xref="GOA:O07599" /db_xref="SubtiList:BG13047" /db_xref="UniProtKB/Swiss-Prot:O07599" /translation="MMEVGILPVHVLYVFFIGAIILFMLLRKDTTFISLFGIFIISLW ASHSLSASVSSLFHSFIYAAGELLPTIFIICFIVSMSDLLTKTGINEAMISPFASLVR GPVTAYWLIGGLMFAISLFFWPSPGVALIGAVLLPAAARAGLTPLAAAMAMNLFGHGF ALSGDFVIQAAPKLTADAAGIPVGDVVSASIPLVLIMGVTTTTAAFIMIQRERKKQEH PTSFSPVLSGEQDNSLYLPKRLRSILAFLIPLAFLADIACMLLFNLQGNDATALIGGS AICILFTVHFFVYKHKGLEKITGYFIDGFKFGFKVFGPVIPIAAFFYLGDSGYESILG TSLPKGSHGIVNDLGIALSHMMPMSKELAATALTAAGAITGLDGSGFSGISLAGSIAK LFSSALHADPAILTALGQISAIWVGGGTLVPWALIPAAAICKVDPFELARKNFIPVAI GLLVTTLAAVMML*" /label="yhfA CDS" gene complement(1030990..1032381) /gene="yhfA" /locus_tag="BSU_10080" /old_locus_tag="BSU10080" /label="yhfA gene" promotor_-10 complement(1032392..1032411) /Source="Nicolas_upshift_promotors" /id="U811" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1283 /SigmaFactorBS="ttccatcataaccctcccctctgtCCCGGCACCTtccgcccg cctaTGAATAATCTGTAAGCGGAAggagtgatcgatgatggaagtcgggattttgcct g" /listShort="yhfA, yhaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1032397) /Source="Nicolas_upshifts" /id="U811" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1283 /SigmaFactorBS="ttccatcataaccctcccctctgtCCCGGCACCTtccgcccg cctaTGAATAATCTGTAAGCGGAAggagtgatcgatgatggaagtcgggattttgcct g" /listShort="yhfA, yhaA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1032424..1032433) /Source="Nicolas_upshift_promotors" /id="U811" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1283 /SigmaFactorBS="ttccatcataaccctcccctctgtCCCGGCACCTtccgcccg cctaTGAATAATCTGTAAGCGGAAggagtgatcgatgatggaagtcgggattttgcct g" /listShort="yhfA, yhaA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1032447..1032761) /gene="yhgB" /locus_tag="BSU_10090" /old_locus_tag="BSU10090" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388890.1" /db_xref="EnsemblGenomes-Gn:BSU10090" /db_xref="EnsemblGenomes-Tr:CAB12849" /db_xref="SubtiList:BG10426" /db_xref="UniProtKB/Swiss-Prot:P38048" /translation="MKHTCPVCGFKDWLNRHMIMKAIILMKSARAAVFSSDLMSTRCS TRITHIEPSESIIAYRKNWLAEGCVIFSPECFPKHLQKANRGLRHHLIEQLKQINVHL PS*" /label="yhgB CDS" gene complement(1032447..1032761) /gene="yhgB" /locus_tag="BSU_10090" /old_locus_tag="BSU10090" /label="yhgB gene" CDS complement(1032806..1033306) /gene="hmoB" /locus_tag="BSU_10100" /old_locus_tag="BSU10100" /EC_number="1.14.99.48" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:21873409, 22531134, 24582752" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21873409, 22531134, 24582752; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="heme-degrading monooxygenase" /protein_id="NP_388891.1" /db_xref="EnsemblGenomes-Gn:BSU10100" /db_xref="EnsemblGenomes-Tr:CAB12850" /db_xref="GOA:P38049" /db_xref="InterPro:IPR007138" /db_xref="InterPro:IPR011008" /db_xref="PDB:4OZ5" /db_xref="SubtiList:BG10427" /db_xref="UniProtKB/Swiss-Prot:P38049" /translation="MKVYITYGTADFLKTIVQKHPSENILLMQGQENAILIHETNGDT VFQAPHAYEVIDQVGEIKHPGFAVLNNIAVTQEGRPLFENRFKNRAGKVENEPGFEAI RVLRPLDSDTYVILTLWETESAFQDWQQSGSYKEAHKKRDTSAGIDTTSIFSRPSYVT TYFAVE*" /label="hmoB CDS" gene complement(1032806..1033306) /gene="hmoB" /locus_tag="BSU_10100" /old_locus_tag="BSU10100" /label="hmoB gene" downshifts complement(1032833) /Source="Nicolas_upshifts" /id="D549" /incds=0 /nref=145 /ntot=254 /MaxReadThrough="3.45185" /MaxDrop="5.6374" /score="15.5142908" /energy="-14.8" /TU="U812" /idTUdmin="U812" /TUdmin="-546" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1033319..1033338) /Source="Nicolas_upshift_promotors" /id="U812" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.555444555444555" /psig="0.98101898101898" /xcortree=101 /SigmaFactorBS="tatgggaaaaattgtttggaattatgttcgaagcactcgcca atAGaaacttataccattgtTTTGATATACTAGCAAGCAGgaggtggctgatatgaag g" /listShort="yhgC, yhgB, yhfA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 1033321..1033325 /Source="Nicolas_upshift_promotors" /id="U813" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.953046953046953" /psig="0.957042957042957" /xcortree=1837 /SigmaFactorBS="tcccatatgtaatataaaccttcatatcagccacctcctGCT TGctagtatatcaaaacAATGGTATAAGTTTCTATTGgcgagtgcttcgaacataatt c" /listShort="pbpF, hemE, hemH, hemY" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1033340) /Source="Nicolas_upshifts" /id="U812" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.555444555444555" /psig="0.98101898101898" /xcortree=101 /SigmaFactorBS="tatgggaaaaattgtttggaattatgttcgaagcactcgcca atAGaaacttataccattgtTTTGATATACTAGCAAGCAGgaggtggctgatatgaag g" /listShort="yhgC, yhgB, yhfA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1033341..1033360 /Source="Nicolas_upshift_promotors" /id="U813" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.953046953046953" /psig="0.957042957042957" /xcortree=1837 /SigmaFactorBS="tcccatatgtaatataaaccttcatatcagccacctcctGCT TGctagtatatcaaaacAATGGTATAAGTTTCTATTGgcgagtgcttcgaacataatt c" /listShort="pbpF, hemE, hemH, hemY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1033342 /Source="Nicolas_upshifts" /id="U813" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.953046953046953" /psig="0.957042957042957" /xcortree=1837 /SigmaFactorBS="tcccatatgtaatataaaccttcatatcagccacctcctGCT TGctagtatatcaaaacAATGGTATAAGTTTCTATTGgcgagtgcttcgaacataatt c" /listShort="pbpF, hemE, hemH, hemY" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1033355..1033356) /Source="Nicolas_upshift_promotors" /id="U812" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.555444555444555" /psig="0.98101898101898" /xcortree=101 /SigmaFactorBS="tatgggaaaaattgtttggaattatgttcgaagcactcgcca atAGaaacttataccattgtTTTGATATACTAGCAAGCAGgaggtggctgatatgaag g" /listShort="yhgC, yhgB, yhfA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1033373..1033379 /Source="Nicolas_upshift_promotors" /id="U814" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=871 /SigmaFactorBS="acaatggtataagtttctattggcgagtgcttcgAACATAAt tccaaacaattttTCCCATACTACCtttagaaaggcgaggtgagttcatgtttaagat a" /listShort="pbpF, hemE, hemH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1033394..1033405 /Source="Nicolas_upshift_promotors" /id="U814" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=871 /SigmaFactorBS="acaatggtataagtttctattggcgagtgcttcgAACATAAt tccaaacaattttTCCCATACTACCtttagaaaggcgaggtgagttcatgtttaagat a" /listShort="pbpF, hemE, hemH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1033399 /Source="Nicolas_upshifts" /id="U814" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=871 /SigmaFactorBS="acaatggtataagtttctattggcgagtgcttcgAACATAAt tccaaacaattttTCCCATACTACCtttagaaaggcgaggtgagttcatgtttaagat a" /listShort="pbpF, hemE, hemH" /GFF_Attribute="listLong" /label="upshifts" CDS 1033428..1035572 /gene="pbpF" /locus_tag="BSU_10110" /old_locus_tag="BSU10110" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8335642, 11567005, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8335642, 11567005, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="penicillin-binding protein 2C (1F class) required for spore germination" /protein_id="NP_388892.2" /db_xref="EnsemblGenomes-Gn:BSU10110" /db_xref="EnsemblGenomes-Tr:CAB12851" /db_xref="GOA:P38050" /db_xref="InterPro:IPR001264" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR023346" /db_xref="InterPro:IPR036950" /db_xref="SubtiList:BG10428" /db_xref="UniProtKB/Swiss-Prot:P38050" /translation="MFKIKKKKLFIPIIILVLTAFLALIGYISIIFLGHYVIDEKKLI LHASSKIVDQNGDEVASLYTENREPVSINEIPKQVREAFIAVEDKRFYEHHGIDAKSV GRAVYRDILAGGKVEGGSTITQQLAKNIFLTHDKTFLRKTKEVIIAINLERDYSKDKL LEMYLNQLYFGHGVYGIQAASHYYFNKEVKDLTVSEGAVLAAIPKAPSTYSPILHPDK NKERRDTILGMMNDQGYISAKEAVTAQGRTLGLHVKKQSETPWFDSYIDLVIKEAEDK YSISGEQLLQGGYTIKVPLDSKLQKTAYQVMKEGSYYPGTDQNAEGSAVFINNKTGGV EAAIGGRDYTSKGYNRVTAVRQPGSTFKPLAVYGPAMQEKKFKPYSLLKDELQSYGDY TPKNYDSRYEGEVTMSDAITYSKNAPAVWTLNEIGVETGKSYLKANGIDIPDEGLALA LGGLEKGVSPLQLAGAFHTFAANGTYTEPFFISSIIDEDGETIADHKEEGKRVFSKQT SWNMTRMLQQVVKKGTATSGTYHGDLAGKTGSTSYTGVSGATKDAWFAGYTPKITGAV WMGYDKTDQNHYLKAGSSYPTRLFKDILTQAGETGHVFTKPKNVKELESPIELKPVKT LTADYTFKAAGLFTIELKWDAQEDDRAVYRIYVNKDGEETLLDSVEGKGSYEIPYANL FSGASYKIVPYNTQTKREGEGTDYVQPKLFSS*" /label="pbpF CDS" gene 1033428..1035572 /gene="pbpF" /locus_tag="BSU_10110" /old_locus_tag="BSU10110" /label="pbpF gene" promotor_-10 complement(1033472..1033483) /Source="Nicolas_upshift_promotors" /id="U815" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.595404595404595" /psig="0.595404595404595" /xcortree=1190 /SigmaFactorBS="ataatggccgagaaaaataattgaaatatatcCTATTAAagc gagaaaagcaGTTAACACTAAAataatgataggtataaaaagtttctttttctttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1033475) /Source="Nicolas_upshifts" /id="U815" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.595404595404595" /psig="0.595404595404595" /xcortree=1190 /SigmaFactorBS="ataatggccgagaaaaataattgaaatatatcCTATTAAagc gagaaaagcaGTTAACACTAAAataatgataggtataaaaagtttctttttctttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1033497..1033503) /Source="Nicolas_upshift_promotors" /id="U815" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.595404595404595" /psig="0.595404595404595" /xcortree=1190 /SigmaFactorBS="ataatggccgagaaaaataattgaaatatatcCTATTAAagc gagaaaagcaGTTAACACTAAAataatgataggtataaaaagtttctttttctttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1035609..1035615 /Source="Nicolas_upshift_promotors" /id="U816" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.377622377622378" /psig="0.998001998001998" /xcortree=1606 /SigmaFactorBS="tcggcgattttttgaactttgagctacattTCTATACcattt gcctaaaaCAAGGTATAGTGTAATAAGTcaagaaatacgaacgtatggttgccgtatg a" /listShort="hemE, hemH, hemY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1035629..1035648 /Source="Nicolas_upshift_promotors" /id="U816" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.377622377622378" /psig="0.998001998001998" /xcortree=1606 /SigmaFactorBS="tcggcgattttttgaactttgagctacattTCTATACcattt gcctaaaaCAAGGTATAGTGTAATAAGTcaagaaatacgaacgtatggttgccgtatg a" /listShort="hemE, hemH, hemY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1035639 /Source="Nicolas_upshifts" /id="U816" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.377622377622378" /psig="0.998001998001998" /xcortree=1606 /SigmaFactorBS="tcggcgattttttgaactttgagctacattTCTATACcattt gcctaaaaCAAGGTATAGTGTAATAAGTcaagaaatacgaacgtatggttgccgtatg a" /listShort="hemE, hemH, hemY" /GFF_Attribute="listLong" /label="upshifts" CDS 1035694..1036755 /gene="hemE" /locus_tag="BSU_10120" /old_locus_tag="BSU10120" /EC_number="4.1.1.37" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10217486, 17122346" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10217486, 17122346; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="uroporphyrinogen III decarboxylase" /protein_id="NP_388893.1" /db_xref="EnsemblGenomes-Gn:BSU10120" /db_xref="EnsemblGenomes-Tr:CAB12852" /db_xref="GOA:P32395" /db_xref="InterPro:IPR000257" /db_xref="InterPro:IPR006361" /db_xref="PDB:2INF" /db_xref="SubtiList:BG10429" /db_xref="UniProtKB/Swiss-Prot:P32395" /translation="MSKRETFNETFLKAARGEKADHTPVWYMRQAGRSQPEYRKLKEK YGLFEITHQPELCAYVTRLPVEQYGVDAAILYKDIMTPLPSIGVDVEIKNGIGPVIDQ PIRSLADIEKLGQIDPEQDVPYVLETIKLLVNEQLNVPLIGFSGAPFTLASYMIEGGP SKNYNKTKAFMYSMPDAWNLLMSKLADMIIVYVKAQIEAGAKAIQIFDSWVGALNQAD YRTYIKPVMNRIFSELAKENVPLIMFGVGASHLAGDWHDLPLDVVGLDWRLGIDEARS KGITKTVQGNLDPSILLAPWEVIEQKTKEILDQGMESDGFIFNLGHGVFPDVSPEVLK KLTAFVHEYSQNKKMGQYS*" /label="hemE CDS" gene 1035694..1036755 /gene="hemE" /locus_tag="BSU_10120" /old_locus_tag="BSU10120" /label="hemE gene" CDS 1036827..1037759 /gene="hemH" /locus_tag="BSU_10130" /old_locus_tag="BSU10130" /EC_number="4.99.1.1" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:8119288, 12686546, 12761666, 16140324, 16453119, 17198378, 20543190, 21052751" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8119288, 12686546, 12761666, 16140324, 16453119, 17198378, 20543190, 21052751; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ferrochelatase" /protein_id="NP_388894.1" /db_xref="EnsemblGenomes-Gn:BSU10130" /db_xref="EnsemblGenomes-Tr:CAB12853" /db_xref="GOA:P32396" /db_xref="InterPro:IPR001015" /db_xref="InterPro:IPR019772" /db_xref="InterPro:IPR033644" /db_xref="InterPro:IPR033659" /db_xref="PDB:1AK1" /db_xref="PDB:1C1H" /db_xref="PDB:1C9E" /db_xref="PDB:1DOZ" /db_xref="PDB:1FJI" /db_xref="PDB:1LD3" /db_xref="PDB:1N0I" /db_xref="PDB:2AC2" /db_xref="PDB:2AC4" /db_xref="PDB:2H1V" /db_xref="PDB:2H1W" /db_xref="PDB:2HK6" /db_xref="PDB:2Q2N" /db_xref="PDB:2Q2O" /db_xref="PDB:2Q3J" /db_xref="PDB:3GOQ" /db_xref="PDB:3M4Z" /db_xref="SubtiList:BG10430" /db_xref="UniProtKB/Swiss-Prot:P32396" /translation="MSRKKMGLLVMAYGTPYKEEDIERYYTHIRRGRKPEPEMLQDLK DRYEAIGGISPLAQITEQQAHNLEQHLNEIQDEITFKAYIGLKHIEPFIEDAVAEMHK DGITEAVSIVLAPHFSTFSVQSYNKRAKEEAEKLGGLTITSVESWYDEPKFVTYWVDR VKETYASMPEDERENAMLIVSAHSLPEKIKEFGDPYPDQLHESAKLIAEGAGVSEYAV GWQSEGNTPDPWLGPDVQDLTRDLFEQKGYQAFVYVPVGFVADHLEVLYDNDYECKVV TDDIGASYYRPEMPNAKPEFIDALATVVLKKLGR*" /label="hemH CDS" gene 1036827..1037759 /gene="hemH" /locus_tag="BSU_10130" /old_locus_tag="BSU10130" /label="hemH gene" CDS 1037774..1039186 /gene="hemY" /locus_tag="BSU_10140" /old_locus_tag="BSU10140" /EC_number="1.3.3.4" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9217019, 9784236, 10498703, 20543190" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9217019, 9784236, 10498703, 20543190; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous protoporphyrinogen IX and coproporphyrinogen III oxidase" /protein_id="NP_388895.1" /db_xref="EnsemblGenomes-Gn:BSU10140" /db_xref="EnsemblGenomes-Tr:CAB12854" /db_xref="GOA:P32397" /db_xref="InterPro:IPR002937" /db_xref="InterPro:IPR004572" /db_xref="InterPro:IPR036188" /db_xref="PDB:3I6D" /db_xref="SubtiList:BG10431" /db_xref="UniProtKB/Swiss-Prot:P32397" /translation="MSDGKKHVVIIGGGITGLAAAFYMEKEIKEKNLPLELTLVEASP RVGGKIQTVKKDGYIIERGPDSFLERKKSAPQLVKDLGLEHLLVNNATGQSYVLVNRT LHPMPKGAVMGIPTKIAPFVSTGLFSLSGKARAAMDFILPASKTKDDQSLGEFFRRRV GDEVVENLIEPLLSGIYAGDIDKLSLMSTFPQFYQTEQKHRSLILGMKKTRPQGSGQQ LTAKKQGQFQTLSTGLQTLVEEIEKQLKLTKVYKGTKVTKLSHSGSCYSLELDNGVTL DADSVIVTAPHKAAAGMLSELPAISHLKNMHSTSVANVALGFPEGSVQMEHEGTGFVI SRNSDFAITACTWTNKKWPHAAPEGKTLLRAYVGKAGDESIVDLSDNDIINIVLEDLK KVMNINGEPEMTCVTRWHESMPQYHVGHKQRIKELREALASAYPGVYMTGASFEGVGI PDCIDQGKAAVSDALTYLFS*" /label="hemY CDS" gene 1037774..1039186 /gene="hemY" /locus_tag="BSU_10140" /old_locus_tag="BSU10140" /label="hemY gene" downshifts 1037777 /Source="Nicolas_upshifts" /id="D550" /incds=0 /nref=1 /ntot=19 /MaxReadThrough="7.68191" /MaxDrop="2.667" /score="28.7532434" /energy="-11.6" /TU="U813,U816" /idTUdmin="U814" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 1039163 /Source="Nicolas_upshifts" /id="D551" /incds=0 /nref=195 /ntot=254 /MaxReadThrough="2.9859" /MaxDrop="6.7703" /score="28.7532434" /energy="-11.6" /TU="NA" /idTUdmin="U813" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1039247..1039254 /Source="Nicolas_upshift_promotors" /id="U817" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.825174825174825" /psig=1 /xcortree=2648 /SigmaFactorBS="tttgatgtgcaatggcaatattgtgtaaaaaatgATTGAATT gaacagcaggttaTGATACATTTGCATATGTACttaatgactaaaatgttcaaacggt c" /listShort="yhgD, S358, yhgE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1039268..1039287 /Source="Nicolas_upshift_promotors" /id="U817" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.825174825174825" /psig=1 /xcortree=2648 /SigmaFactorBS="tttgatgtgcaatggcaatattgtgtaaaaaatgATTGAATT gaacagcaggttaTGATACATTTGCATATGTACttaatgactaaaatgttcaaacggt c" /listShort="yhgD, S358, yhgE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1039273 /Source="Nicolas_upshifts" /id="U817" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.825174825174825" /psig=1 /xcortree=2648 /SigmaFactorBS="tttgatgtgcaatggcaatattgtgtaaaaaatgATTGAATT gaacagcaggttaTGATACATTTGCATATGTACttaatgactaaaatgttcaaacggt c" /listShort="yhgD, S358, yhgE" /GFF_Attribute="listLong" /label="upshifts" CDS 1039332..1039907 /gene="yhgD" /locus_tag="BSU_10150" /old_locus_tag="BSU10150" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 15944459, 23695570; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of unknown target" /protein_id="NP_388896.1" /db_xref="EnsemblGenomes-Gn:BSU10150" /db_xref="EnsemblGenomes-Tr:CAB12855" /db_xref="GOA:P32398" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR023772" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG10432" /db_xref="UniProtKB/Swiss-Prot:P32398" /translation="MSIDRKKLILEAATKSFTQFGYKATTMDLVAKLANVGKGTIYTF FKNKEELFDEIFTTLLKEMKQKADEAMEPSLPFHENVHRALFAILEFRKTHQLTIKIF QENAEIGTMAVQEVIQKMERSILSYIKSKIEDGIKSGAIKPCDPELTAFVMLKLYIAL IFDWEKQHPPLDKETIAGLLELYVVKGLSAN*" /label="yhgD CDS" gene 1039332..1039907 /gene="yhgD" /locus_tag="BSU_10150" /old_locus_tag="BSU10150" /label="yhgD gene" promotor_-35 1039651..1039654 /Source="Nicolas_upshift_promotors" /id="U818" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.731268731268731" /psig="0.731268731268731" /xcortree=140 /SigmaFactorBS="aaacacatcagctgacgattaaaattttccaagagaatgccg AGATtggtacaatggcagttCAGGAAGTGATCCAGAAAATggagcgatccatcctgtc t" /listShort="S358, yhgE" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1039669 /Source="Nicolas_upshifts" /id="U818" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.731268731268731" /psig="0.731268731268731" /xcortree=140 /SigmaFactorBS="aaacacatcagctgacgattaaaattttccaagagaatgccg AGATtggtacaatggcagttCAGGAAGTGATCCAGAAAATggagcgatccatcctgtc t" /listShort="S358, yhgE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1039671..1039690 /Source="Nicolas_upshift_promotors" /id="U818" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.731268731268731" /psig="0.731268731268731" /xcortree=140 /SigmaFactorBS="aaacacatcagctgacgattaaaattttccaagagaatgccg AGATtggtacaatggcagttCAGGAAGTGATCCAGAAAATggagcgatccatcctgtc t" /listShort="S358, yhgE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1039908..1039977 /Source="Nicolas_S_feature" /locus_tag="new_1090331_1090400" /HighExp="G135, G150, G180, BI, Salt, Etha, Cold, Heat, Oxctl, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="0.731, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S358" CDS 1039978..1042305 /gene="yhgE" /locus_tag="BSU_10160" /old_locus_tag="BSU10160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15576783; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative methyl-accepting protein" /protein_id="NP_388897.1" /db_xref="EnsemblGenomes-Gn:BSU10160" /db_xref="EnsemblGenomes-Tr:CAB12856" /db_xref="GOA:P32399" /db_xref="InterPro:IPR017500" /db_xref="InterPro:IPR017501" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR023908" /db_xref="SubtiList:BG10433" /db_xref="UniProtKB/Swiss-Prot:P32399" /translation="MNTIRSQWKDIVTSKKLLIPIIAILFVPLIYSGVFLKAYWDPYG TVDQLPVVVVNQDKGATYEGEKLQIGDDLVKELKDNNNFDWHFSNDLDQSLKDLLNQK YYLVVEIPEDFSKNASTVLDKNPKKLDLKYHTNAGSNYVGATIGEKAIDKLKASVSKE VTEQYTKVIFDNFKDIAKGLSDASSGAKKIDDGTKDAKNGSAQLKENLAKLKESTATI SDKTAQLADGAAQVTSGIQSLDSSLGKFQDSSNQIYDKSSQLAAGSGELTSKMNELLA GLQNVQKGTPNLTNGLDQLNSKVQEGSEKAAKAEKIINALDLTKLETAVNNLEKSETA MKEFKKQLTDFENSLKNRDQAFKNVINSSDFLTAEQKSQLINSVEKKLPQVDAPDFDQ ILSQLPTADQLPDIATIKSSLEDVKAQVAQVKAMPEATSKLYNGAKTIQDAIDRLTEG ADKIYNGSQKLTDGQTKLTAGIGEYNKQFAKAKAGSEQLVTGSSQVSGGLFKLLDGSK QVQSGSSKLADGSASLDTGLGKLLDGTGELSSKLKDAADQTGDIDADDQTYGMFADPV KTKDDAIHSVPNYGTGLTPYILSMGLYVGGIMLTVVFPLKEASGRPRNGFEWFFSKFN VMMLVGIIQSLIVATVLLLGIGLEVESTWRFYVFTIITSLAFLAIIQFLATTMGNPGR FIAVIILVLQLGASGGTFPLELLPNFYQVIHGALPMTYSINGFRAVISNGDFGYMWQM AGVLIGIALVMIALSITYFTMLSRKEETSEEQPAS*" /label="yhgE CDS" gene 1039978..1042305 /gene="yhgE" /locus_tag="BSU_10160" /old_locus_tag="BSU10160" /label="yhgE gene" downshifts 1042287 /Source="Nicolas_upshifts" /id="D552" /incds=0 /nref=65 /ntot=211 /MaxReadThrough="0.57274" /MaxDrop="5.58483" /score="-4.79013797" /energy="-7.3" /TU="NA" /idTUdmin="U817" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1042347..1043324) /gene="fabHB" /locus_tag="BSU_10170" /old_locus_tag="BSU10170" /EC_number="2.3.1.180" /EC_number="2.3.1.38" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10629181, 21383089, 21542858" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10629181, 21383089, 21542858; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="beta-ketoacyl-acyl carrier protein synthase III 2" /protein_id="NP_388898.1" /db_xref="EnsemblGenomes-Gn:BSU10170" /db_xref="EnsemblGenomes-Tr:CAB12857" /db_xref="GOA:O07600" /db_xref="InterPro:IPR004655" /db_xref="InterPro:IPR013747" /db_xref="InterPro:IPR013751" /db_xref="InterPro:IPR016039" /db_xref="SubtiList:BG13048" /db_xref="UniProtKB/Swiss-Prot:O07600" /translation="MSKAKITAIGTYAPSRRLTNADLEKIVDTSDEWIVQRTGMRERR IADEHQFTSDLCIEAVKNLKSRYKGTLDDVDMILVATTTSDYAFPSTACRVQEYFGWE STGALDINATCAGLTYGLHLANGLITSGLHQKILVIAGETLSKVTDYTDRTTCVLFGD AAGALLVERDEETPGFLASVQGTSGNGGDILYRAGLRNEINGVQLVGSGKMVQNGREV YKWAARTVPGEFERLLHKAGLSSDDLDWFVPHSANLRMIESICEKTPFPIEKTLTSVE HYGNTSSVSIVLALDLAVKAGKLKKDQIVLLFGFGGGLTYTGLLIKWGM*" /label="fabHB CDS" gene complement(1042347..1043324) /gene="fabHB" /locus_tag="BSU_10170" /old_locus_tag="BSU10170" /label="fabHB gene" downshifts complement(1042360) /Source="Nicolas_upshifts" /id="D553" /incds=0 /nref=21 /ntot=217 /MaxReadThrough="1.99012" /MaxDrop="7.90433" /score="-9.17544275" /energy="-7.3" /TU="NA" /idTUdmin="U819" /TUdmin="-19" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1043338..1043357) /Source="Nicolas_upshift_promotors" /id="U819" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.466533466533467" /psig="0.999000999001" /xcortree=2184 /SigmaFactorBS="atctacacttctctttttttgtaaaaaaaccttctttttAGT ACCAgatactaatatctAGTGTTATAATCTGACCATAaggagtgattcatatgtcaaa a" /listShort="fabHB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1043356) /Source="Nicolas_upshifts" /id="U819" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.466533466533467" /psig="0.999000999001" /xcortree=2184 /SigmaFactorBS="atctacacttctctttttttgtaaaaaaaccttctttttAGT ACCAgatactaatatctAGTGTTATAATCTGACCATAaggagtgattcatatgtcaaa a" /listShort="fabHB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1043371..1043377) /Source="Nicolas_upshift_promotors" /id="U819" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.466533466533467" /psig="0.999000999001" /xcortree=2184 /SigmaFactorBS="atctacacttctctttttttgtaaaaaaaccttctttttAGT ACCAgatactaatatctAGTGTTATAATCTGACCATAaggagtgattcatatgtcaaa a" /listShort="fabHB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1043383..1043391 /Source="Nicolas_upshift_promotors" /id="U820" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3194 /SigmaFactorBS="tataacactagatattagtatctggtactaaaaaGAAGGTTT TtttacaaaaaAAGAGAAGTGTAGATAGGAatctatgaaaaagaaaaaggaggctgaa a" /listShort="yhfC, S360, yhfE, yhfF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1043402..1043420 /Source="Nicolas_upshift_promotors" /id="U820" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3194 /SigmaFactorBS="tataacactagatattagtatctggtactaaaaaGAAGGTTT TtttacaaaaaAAGAGAAGTGTAGATAGGAatctatgaaaaagaaaaaggaggctgaa a" /listShort="yhfC, S360, yhfE, yhfF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1043409 /Source="Nicolas_upshifts" /id="U820" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3194 /SigmaFactorBS="tataacactagatattagtatctggtactaaaaaGAAGGTTT TtttacaaaaaAAGAGAAGTGTAGATAGGAatctatgaaaaagaaaaaggaggctgaa a" /listShort="yhfC, S360, yhfE, yhfF" /GFF_Attribute="listLong" /label="upshifts" CDS 1043451..1044227 /gene="yhfC" /locus_tag="BSU_10180" /old_locus_tag="BSU10180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_388899.1" /db_xref="EnsemblGenomes-Gn:BSU10180" /db_xref="EnsemblGenomes-Tr:CAB12858" /db_xref="GOA:O07601" /db_xref="InterPro:IPR011397" /db_xref="SubtiList:BG13049" /db_xref="UniProtKB/Swiss-Prot:O07601" /translation="MVSQEAVVFLALSGAIAFLLPIGLIVWFKRKYGASLKVFFIGAL TFFVFAQLLEGGVHVYVLQVNEMTKEAMQHPLWYGIYGCLMAGIFEECGRYLMMRFFM KRHHTWADGLAFGAGHGGLEAILITGLSSISLIVYAFAINSGTFEQLLVNGDVKQALL PIQEQLLHTPSYEWMLGGIERISAIAVQIGLSLLVLYAVKNRRPLFLLYSILLHALFN VPAVLYQRGIIEHAAAVEIIVALIAALSVYWIVKAKRVFQ*" /label="yhfC CDS" gene 1043451..1044227 /gene="yhfC" /locus_tag="BSU_10180" /old_locus_tag="BSU10180" /label="yhfC gene" S_feature complement(1043943..1044564) /Source="Nicolas_S_feature" /locus_tag="new_1094366_1094987_c" /HighExp="B36, BT, B60, Pyr, S8, G/S, G135, Mal, M/G, Glucon" /AntisenseName="yhfC" /AntisenseCor="-0.12937903461570099" /AntisenseRegPval="-1.5" /CDS_PredictionProba="0.51248700000000003" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S359" S_feature 1044228..1044599 /Source="Nicolas_S_feature" /locus_tag="new_1094651_1095022" /HighExp="Lbstat, S2, M0t90, M40t90, HiOs, SMMPr, T-2.40H, Etha, Lbtran, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.48518699999999998" /TUshortSig="SigH" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S360" promotor_-10 complement(1044542..1044561) /Source="Nicolas_upshift_promotors" /id="U821" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1428 /SigmaFactorBS="tattttctacttaaaatatactcttttcccgagggacccGTC CAATCTTttcctatcaatctCTCATATGCTGTAGAGAGCAtgggaagaggagggattt c" /listShort="S359" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1044563) /Source="Nicolas_upshifts" /id="U821" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1428 /SigmaFactorBS="tattttctacttaaaatatactcttttcccgagggacccGTC CAATCTTttcctatcaatctCTCATATGCTGTAGAGAGCAtgggaagaggagggattt c" /listShort="S359" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1044575..1044584) /Source="Nicolas_upshift_promotors" /id="U821" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1428 /SigmaFactorBS="tattttctacttaaaatatactcttttcccgagggacccGTC CAATCTTttcctatcaatctCTCATATGCTGTAGAGAGCAtgggaagaggagggattt c" /listShort="S359" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1044577..1044584 /Source="Nicolas_upshift_promotors" /id="U822" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.78921078921079" /psig="0.96003996003996" /xcortree=2233 /SigmaFactorBS="atgctctctacagcatatgagagattgataggaaaaGATTGG ACgggtccctcgggaaAAGAGTATATTTTAAGTAGAaaataaaaggaggaatgcccta t" /listShort="yhfE, yhfF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1044599..1044618 /Source="Nicolas_upshift_promotors" /id="U822" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.78921078921079" /psig="0.96003996003996" /xcortree=2233 /SigmaFactorBS="atgctctctacagcatatgagagattgataggaaaaGATTGG ACgggtccctcgggaaAAGAGTATATTTTAAGTAGAaaataaaaggaggaatgcccta t" /listShort="yhfE, yhfF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1044601 /Source="Nicolas_upshifts" /id="U822" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.78921078921079" /psig="0.96003996003996" /xcortree=2233 /SigmaFactorBS="atgctctctacagcatatgagagattgataggaaaaGATTGG ACgggtccctcgggaaAAGAGTATATTTTAAGTAGAaaataaaaggaggaatgcccta t" /listShort="yhfE, yhfF" /GFF_Attribute="listLong" /label="upshifts" CDS 1044640..1045680 /gene="yhfE" /locus_tag="BSU_10200" /old_locus_tag="BSU10200" /EC_number="3.4.11.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15713475, 15743956; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aminopeptidase" /protein_id="NP_388901.1" /db_xref="EnsemblGenomes-Gn:BSU10200" /db_xref="EnsemblGenomes-Tr:CAB12860" /db_xref="GOA:O07603" /db_xref="InterPro:IPR008007" /db_xref="InterPro:IPR023367" /db_xref="SubtiList:BG13051" /db_xref="UniProtKB/Swiss-Prot:O07603" /translation="MTSVRKTMELIKELVSIPSPTGNTYEVINYIESLLKEWKVETVR NHKGGLIATLPGRDTSRHRMLTAHVDTLGAMVKEIKADGRLKIDLIGGFRYNSIEGEY CQIETASGKMYTGTILMHQTSVHVYKDAGKAERNQENMEIRLDEPVHCRKDTEELGIG VGDFVSFDPRVEITSSGFIKSRHLDDKASVALLLRLIHEIQTEDIELPYTTHFLISNN EEIGYGGNSNIPPETVEYLAVDMGAIGDGQATDEYSVSICVKDASGPYHYQLRKHLVQ LAEKHHIDYKLDIYPYYGSDASAAIKSGHDIVHGLIGPGIDASHAFERTHKSSLRHTA KLLYYYVQSPMV*" /label="yhfE CDS" gene 1044640..1045680 /gene="yhfE" /locus_tag="BSU_10200" /old_locus_tag="BSU10200" /label="yhfE gene" CDS 1045693..1046100 /gene="yhfF" /locus_tag="BSU_10210" /old_locus_tag="BSU10210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11157739, 14517985; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA-binding PUA-containing enzyme" /protein_id="NP_388902.1" /db_xref="EnsemblGenomes-Gn:BSU10210" /db_xref="EnsemblGenomes-Tr:CAB12861" /db_xref="InterPro:IPR007374" /db_xref="InterPro:IPR009326" /db_xref="InterPro:IPR015947" /db_xref="SubtiList:BG13052" /db_xref="UniProtKB/Swiss-Prot:O07604" /translation="MKIYKLKSTFGWEGDDGLGEQLIQQILAGEKSATCAPKSLYSKD ELRDVYQTAGQLVTVYDKHDNPRCNIKVTDVFETTFGAPDMRLVKGEGNGDRIEEFQE DHRMAWAELIKSGELELNEDTVLITELFVLVKD*" /label="yhfF CDS" gene 1045693..1046100 /gene="yhfF" /locus_tag="BSU_10210" /old_locus_tag="BSU10210" /label="yhfF gene" downshifts 1046071 /Source="Nicolas_upshifts" /id="D554" /incds=0 /nref=24 /ntot=228 /MaxReadThrough="0.87656" /MaxDrop="5.21108" /score="22.0862441" /energy="-20.3" /TU="U822" /idTUdmin="U822" /TUdmin="-23" /isTUend="FALSE" /label="downshifts" CDS complement(1046137..1047426) /gene="gltT" /locus_tag="BSU_10220" /old_locus_tag="BSU10220" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8634258, 10588697, 11148213, 15849754, 16850406, 17673229, 25344233" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8634258, 10588697, 11148213, 15849754, 16850406, 17673229, 25344233; Product type t: transporter" /codon_start=1 /transl_table=11 /product="proton/sodium-glutamate (aspartate) symport permease" /protein_id="NP_388903.1" /db_xref="EnsemblGenomes-Gn:BSU10220" /db_xref="EnsemblGenomes-Tr:CAB12862" /db_xref="GOA:O07605" /db_xref="InterPro:IPR001991" /db_xref="InterPro:IPR018107" /db_xref="InterPro:IPR033380" /db_xref="InterPro:IPR036458" /db_xref="SubtiList:BG12595" /db_xref="UniProtKB/Swiss-Prot:O07605" /translation="MKRIKFGLATQIFVGLILGVIVGVIWYGNPALPTYLQPIGDLFL RLIKMIVIPIVVSSLIIGVAGAGNGKQVGKLGFRTILYFEIITTFAIILGLALANIFH PGTGVNIHEAQKSDISQYVETEKEQSNKSVAETFLHIVPTNFFQSLVEGDLLAIICFT VLFALGISAIGERGKPVLAFFEGVSHAMFHVVNLVMKVAPFGVFALIGVTVSKFGLGS LISLGKLVGLVYVALAFFLIVIFGIVAKIAGISIFKFLAYMKDEILLAFSTSSSETVL PRIMEKMEKIGCPKGIVSFVIPIGYTFNLDGSVLYQSIAALFLAQVYGIDLTIWHQIT LVLVLMVTSKGMAAVPGTSFVVLLATLGTIGVPAEGLAFIAGVDRIMDMARTVVNLTG NALAAVVMSKWEGMFNPAKAETVMSQSKTEQNATISG*" /label="gltT CDS" gene complement(1046137..1047426) /gene="gltT" /locus_tag="BSU_10220" /old_locus_tag="BSU10220" /label="gltT gene" downshifts complement(1046167) /Source="Nicolas_upshifts" /id="D555" /incds=0 /nref=226 /ntot=280 /MaxReadThrough="2.99263" /MaxDrop="7.79183" /score="48.7726082" /energy="-21.9" /TU="U823" /idTUdmin="U824" /TUdmin=3 /isTUend="TRUE" /label="downshifts" S_feature complement(1047427..1047527) /Source="Nicolas_S_feature" /locus_tag="new_1097850_1097950_c" /HighExp="C90, LoTm, LBGexp, Cold, UNK1, BC, dia5, Lbexp, S1, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S361" promotor_-10 complement(1047526..1047545) /Source="Nicolas_upshift_promotors" /id="U823" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.556443556443556" /psig=1 /xcortree=2240 /SigmaFactorBS="tctggtgattatcataatgtcATTGAATattctttattttcg AAATATAATTTACTATAGACgaattgatttcttatctattataatttgatctaatagt g" /listShort="S361, gltT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1047527) /Source="Nicolas_upshifts" /id="U823" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.556443556443556" /psig=1 /xcortree=2240 /SigmaFactorBS="tctggtgattatcataatgtcATTGAATattctttattttcg AAATATAATTTACTATAGACgaattgatttcttatctattataatttgatctaatagt g" /listShort="S361, gltT" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1047529..1047665) /Source="Nicolas_S_feature" /locus_tag="new_1097952_1098088_c" /HighExp="M9-stat, T3.30H, T3.0H, T4.0H, T2.30H, T5.0H, Cold, T2.0H, S0, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S362" promotor_-35 complement(1047560..1047566) /Source="Nicolas_upshift_promotors" /id="U823" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.556443556443556" /psig=1 /xcortree=2240 /SigmaFactorBS="tctggtgattatcataatgtcATTGAATattctttattttcg AAATATAATTTACTATAGACgaattgatttcttatctattataatttgatctaatagt g" /listShort="S361, gltT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1047697..1047837) /gene="yhfH" /locus_tag="BSU_10230" /old_locus_tag="BSU10230" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388904.1" /db_xref="EnsemblGenomes-Gn:BSU10230" /db_xref="EnsemblGenomes-Tr:CAB12863" /db_xref="InterPro:IPR025432" /db_xref="SubtiList:BG13053" /db_xref="UniProtKB/Swiss-Prot:O07606" /translation="MVMLGKITEFFRNLPSKKCAECGKKIEEQHECYGNICNDCIKVN DL*" /label="yhfH CDS" gene complement(1047697..1047837) /gene="yhfH" /locus_tag="BSU_10230" /old_locus_tag="BSU10230" /label="yhfH gene" downshifts complement(1047710) /Source="Nicolas_upshifts" /id="D556" /incds=0 /nref=3 /ntot=16 /MaxReadThrough="5.70702" /MaxDrop="4.73949" /score="28.7665297" /energy="-13.6" /TU="U824" /idTUdmin="U824" /TUdmin="-1540" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1047856..1047875) /Source="Nicolas_upshift_promotors" /id="U824" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.454545454545455" /psig=1 /xcortree=433 /SigmaFactorBS="tcttgaaaaaagcatgttttaaacattgtatcaaaacagtTA TTGATTtttgtaatctgtTATATTACAATGAAATCACTacaaaggggaaagagggatt g" /listShort="yhfH, S362, S361, gltT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1047875) /Source="Nicolas_upshifts" /id="U824" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.454545454545455" /psig=1 /xcortree=433 /SigmaFactorBS="tcttgaaaaaagcatgttttaaacattgtatcaaaacagtTA TTGATTtttgtaatctgtTATATTACAATGAAATCACTacaaaggggaaagagggatt g" /listShort="yhfH, S362, S361, gltT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1047888..1047895) /Source="Nicolas_upshift_promotors" /id="U824" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.454545454545455" /psig=1 /xcortree=433 /SigmaFactorBS="tcttgaaaaaagcatgttttaaacattgtatcaaaacagtTA TTGATTtttgtaatctgtTATATTACAATGAAATCACTacaaaggggaaagagggatt g" /listShort="yhfH, S362, S361, gltT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1047919..1047925 /Source="Nicolas_upshift_promotors" /id="U825" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.621378621378621" /psig="0.99100899100899" /xcortree=1999 /SigmaFactorBS="tacaaaaatcaataactgttttgatacaatgtttaaaACATG CTtttttcaagaaaaATGGGTATATTGAAGGAGGAccaatttttttgaaaagatagga g" /listShort="yhfI, yhfJ, yhfK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1047939..1047958 /Source="Nicolas_upshift_promotors" /id="U825" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.621378621378621" /psig="0.99100899100899" /xcortree=1999 /SigmaFactorBS="tacaaaaatcaataactgttttgatacaatgtttaaaACATG CTtttttcaagaaaaATGGGTATATTGAAGGAGGAccaatttttttgaaaagatagga g" /listShort="yhfI, yhfJ, yhfK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1047942 /Source="Nicolas_upshifts" /id="U825" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.621378621378621" /psig="0.99100899100899" /xcortree=1999 /SigmaFactorBS="tacaaaaatcaataactgttttgatacaatgtttaaaACATG CTtttttcaagaaaaATGGGTATATTGAAGGAGGAccaatttttttgaaaagatagga g" /listShort="yhfI, yhfJ, yhfK" /GFF_Attribute="listLong" /label="upshifts" CDS 1047989..1048723 /gene="yhfI" /locus_tag="BSU_10240" /old_locus_tag="BSU10240" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent hydrolase" /protein_id="NP_388905.1" /db_xref="EnsemblGenomes-Gn:BSU10240" /db_xref="EnsemblGenomes-Tr:CAB12864" /db_xref="GOA:O07607" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG13054" /db_xref="UniProtKB/Swiss-Prot:O07607" /translation="MKVTVIGCYGGFPAANEATSGYLFQSGDYSLLVDCGSAVLSKLF GYVPAEKLDAVVLSHYHHDHIADIGPLQFAKQVGSFLGKGEHTLPIYGHDADIEQFQK LTYKTHTKGIAYQPDQPLTAGPFTITFLKTIHPVTCYAMRITDGSHTVVYTADSSYQD SFIPFSKDADLLISECNFYADQDGTSAGHMNSLEAGRIAKEAGAGELLLTHLPHFGVH DNLRKEAKTVFNGEVNIAKSGFVWEG*" /label="yhfI CDS" gene 1047989..1048723 /gene="yhfI" /locus_tag="BSU_10240" /old_locus_tag="BSU10240" /label="yhfI gene" CDS 1048736..1049731 /gene="lplJ" /locus_tag="BSU_10250" /old_locus_tag="BSU10250" /EC_number="6.3.1.20" /experiment="publication(s) with functional evidences, PMID:21338420, 21338421" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21338420, 21338421; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="lipoate-protein ligase" /protein_id="NP_388906.1" /db_xref="EnsemblGenomes-Gn:BSU10250" /db_xref="EnsemblGenomes-Tr:CAB12865" /db_xref="GOA:O07608" /db_xref="InterPro:IPR004143" /db_xref="InterPro:IPR004562" /db_xref="InterPro:IPR019491" /db_xref="SubtiList:BG13055" /db_xref="UniProtKB/Swiss-Prot:O07608" /translation="MLFIDNQNINDPRINLAIEEYCVKHLDPEQQYLLFYVNQPSIII GKNQNTIEEINTKYVEENGIIVVRRLSGGGAVYHDLGNLNFSFITKDDGDSFHNFKKF TEPVIQALHQLGVEAELSGRNDIVVDGRKISGNAQFATKGRIFSHGTLMFDSAIDHVV SALKVKKDKIESKGIKSIRSRVANISEFLDDKMTTEEFRSHLLRHIFNTNDVGNVPEY KLTEKDWETIHQISKERYQNWDWNYGRSPKFNLNHSKRYPVGSIDLHLEVKKGKIEDC KIFGDFFGVGDVSEIENLLVGKQYERSVIADVLEGVNLKHYFGNITKEDFLDLIY*" /label="lplJ CDS" gene 1048736..1049731 /gene="lplJ" /locus_tag="BSU_10250" /old_locus_tag="BSU10250" /label="lplJ gene" CDS 1049796..1050440 /gene="yhfK" /locus_tag="BSU_10260" /old_locus_tag="BSU10260" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11790741; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD-binding epimerase / hydratase" /protein_id="NP_388907.1" /db_xref="EnsemblGenomes-Gn:BSU10260" /db_xref="EnsemblGenomes-Tr:CAB12866" /db_xref="GOA:O07609" /db_xref="InterPro:IPR016040" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13056" /db_xref="UniProtKB/Swiss-Prot:O07609" /translation="MKVFLIGANGQIGQRLVSLFQDNPDHSIRAMVRKEEQKASLEAA GAEAVLANLEGSPEEIAAAAKGCDAIIFTAGSGGSTGYDKTLLVDLDGAAKAIEAAAI AGIKRFIMVSALQAHNRENWNEALKPYYVAKHYADKILEASGLTYTIIRPGGLRNEPG TGTVSAAKDLERGFISRDDVAKTVIASLDEKNTENRAFDLTEGDTPIAEALKKL*" /label="yhfK CDS" gene 1049796..1050440 /gene="yhfK" /locus_tag="BSU_10260" /old_locus_tag="BSU10260" /label="yhfK gene" downshifts 1050428 /Source="Nicolas_upshifts" /id="D557" /incds=0 /nref=239 /ntot=258 /MaxReadThrough="0.56809" /MaxDrop="6.84076" /score="18.2092404" /energy="-10" /TU="NA" /idTUdmin="U825" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1050468..1050471 /Source="Nicolas_upshift_promotors" /id="U826" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.619380619380619" /psig=1 /xcortree=374 /SigmaFactorBS="aactatgacagtactgacactcagggctttttgctCTTGagt gtttttttctgTTTCTCTATAATGGAGAAGAaagcttggcttcaataatgaatgacta t" /listShort="lcfB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1050486..1050505 /Source="Nicolas_upshift_promotors" /id="U826" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.619380619380619" /psig=1 /xcortree=374 /SigmaFactorBS="aactatgacagtactgacactcagggctttttgctCTTGagt gtttttttctgTTTCTCTATAATGGAGAAGAaagcttggcttcaataatgaatgacta t" /listShort="lcfB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1050493 /Source="Nicolas_upshifts" /id="U826" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.619380619380619" /psig=1 /xcortree=374 /SigmaFactorBS="aactatgacagtactgacactcagggctttttgctCTTGagt gtttttttctgTTTCTCTATAATGGAGAAGAaagcttggcttcaataatgaatgacta t" /listShort="lcfB" /GFF_Attribute="listLong" /label="upshifts" CDS 1050557..1052098 /gene="lcfB" /locus_tag="BSU_10270" /old_locus_tag="BSU10270" /EC_number="6.2.1.3" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17189250, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="long-chain fatty-acid-CoA ligase (degradative)" /protein_id="NP_388908.2" /db_xref="EnsemblGenomes-Gn:BSU10270" /db_xref="EnsemblGenomes-Tr:CAB12867" /db_xref="GOA:O07610" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR020459" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="SubtiList:BG13057" /db_xref="UniProtKB/Swiss-Prot:O07610" /translation="MNLVSKLEETASEKPDSIACRFKDHMMTYQELNEYIQRFADGLQ EAGMEKGDHLALLLGNSPDFIIAFFGALKAGIVVVPINPLYTPTEIGYMLTNGDVKAI VGVSQLLPLYESMHESLPKVELVILCQTGEAEPEAADPEVRMKMTTFAKILRPTSAAK QNQEPVPDDTAVILYTSGTTGKPKGAMLTHQNLYSNANDVAGYLGMDERDNVVCALPM FHVFCLTVCMNAPLMSGATVLIEPQFSPASVFKLVKQQQATIFAGVPTMYNYLFQHEN GKKDDFSSIRLCISGGASMPVALLTAFEEKFGVTILEGYGLSEASPVTCFNPFDRGRK PGSIGTSILHVENKVVDPLGRELPAHQVGELIVKGPNVMKGYYKMPMETEHALKDGWL YTGDLARRDEDGYFYIVDRKKDMIIVGGYNVYPREVEEVLYSHPDVKEAVVIGVPDPQ SGEAVKGYVVPKRSGVTEEDIMQHCEKHLAKYKRPAAITFLDDIPKNATGKMLRRALR DILPQ*" /label="lcfB CDS" gene 1050557..1052098 /gene="lcfB" /locus_tag="BSU_10270" /old_locus_tag="BSU10270" /label="lcfB gene" downshifts 1052078 /Source="Nicolas_upshifts" /id="D558" /incds=0 /nref=5 /ntot=108 /MaxReadThrough="2.74134" /MaxDrop="3.72638" /score="15.3712924" /energy="-10.4" /TU="NA" /idTUdmin="U826" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1052137..1052532) /gene="yhfM" /locus_tag="BSU_10280" /old_locus_tag="BSU10280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="NP_388909.1" /db_xref="EnsemblGenomes-Gn:BSU10280" /db_xref="EnsemblGenomes-Tr:CAB12868" /db_xref="SubtiList:BG13058" /db_xref="UniProtKB/Swiss-Prot:O07611" /translation="MKKIVAAIVVIGLVFIAFFYLYSRSGDVYQSVDADLITLSSSGQ EDIEIEKRQHVKDMLDIMNQGKQVKTEKTSAPDYEGTIKFHKDRYDSFRLWIDGSQQA VFLKDGTYYKLSKNDTKALLNIIKKEAKD*" /label="yhfM CDS" gene complement(1052137..1052532) /gene="yhfM" /locus_tag="BSU_10280" /old_locus_tag="BSU10280" /label="yhfM gene" downshifts complement(1052154) /Source="Nicolas_upshifts" /id="D559" /incds=0 /nref=46 /ntot=89 /MaxReadThrough="0.75539" /MaxDrop="6.88759" /score="17.4775611" /energy="-10.4" /TU="NA" /idTUdmin="U827" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1052552..1052563) /Source="Nicolas_upshift_promotors" /id="U827" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1141 /SigmaFactorBS="caagctgtgttccgcacttttccacccttttaAGCATGGaaa ccccgatcgctGGGAAAACTAACaatgtttggagtgatgcaaatgaaaaaaatagtgg c" /listShort="yhfM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1052556) /Source="Nicolas_upshifts" /id="U827" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1141 /SigmaFactorBS="caagctgtgttccgcacttttccacccttttaAGCATGGaaa ccccgatcgctGGGAAAACTAACaatgtttggagtgatgcaaatgaaaaaaatagtgg c" /listShort="yhfM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1052578..1052584) /Source="Nicolas_upshift_promotors" /id="U827" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1141 /SigmaFactorBS="caagctgtgttccgcacttttccacccttttaAGCATGGaaa ccccgatcgctGGGAAAACTAACaatgtttggagtgatgcaaatgaaaaaaatagtgg c" /listShort="yhfM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1052617..1052620 /Source="Nicolas_upshift_promotors" /id="U828" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.635364635364635" /psig="0.785214785214785" /xcortree=1404 /SigmaFactorBS="atcggggtttccatgcttaaaagggtggaaaagtgcggaaca cagcttgGTTCtaagaatttgaattTATGATTACAATAGAAGTAAcgggttgatgtga g" /listShort="yhfN" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1052628 /Source="Nicolas_upshifts" /id="U828" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.635364635364635" /psig="0.785214785214785" /xcortree=1404 /SigmaFactorBS="atcggggtttccatgcttaaaagggtggaaaagtgcggaaca cagcttgGTTCtaagaatttgaattTATGATTACAATAGAAGTAAcgggttgatgtga g" /listShort="yhfN" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1052635..1052654 /Source="Nicolas_upshift_promotors" /id="U828" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.635364635364635" /psig="0.785214785214785" /xcortree=1404 /SigmaFactorBS="atcggggtttccatgcttaaaagggtggaaaagtgcggaaca cagcttgGTTCtaagaatttgaattTATGATTACAATAGAAGTAAcgggttgatgtga g" /listShort="yhfN" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1052681..1053961 /gene="yhfN" /locus_tag="BSU_10290" /old_locus_tag="BSU10290" /EC_number="3.4.24.84" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9015299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane metalloprotease" /protein_id="NP_388910.1" /db_xref="EnsemblGenomes-Gn:BSU10290" /db_xref="EnsemblGenomes-Tr:CAB12869" /db_xref="GOA:P40769" /db_xref="InterPro:IPR001915" /db_xref="InterPro:IPR027057" /db_xref="InterPro:IPR032456" /db_xref="SubtiList:BG11029" /db_xref="UniProtKB/Swiss-Prot:P40769" /translation="MRKWIAAAGLAYVLYGLFFYWYFFLSGDSAIPEAVKGTQADPAS FMKPSELAVAEQYSNVKNFLFFIGVPLDWFLFFVLLVSGVSKKIKKWIEAAVPFRFLQ TVGFVFVLSLITTLVTLPLDWIGYQVSLDYNISTQTTASWAKDQVISFWISFPIFTLC VLVFYWLIKRHEKKWWLYAWLLTVPFSLFLFFIQPVIIDPLYNDFYPLKNKELESKIL ELADEANIPADHVYEVNMSEKTNALNAYVTGIGANKRIVLWDTTLNKLDDSEILFIMG HEMGHYVMKHVYIGLAGYLLVSLAGFYVIDKLYKRTVRLTRSMFHLEGRHDLAALPLL LLLFSVLSFAVTPFSNAVSRYQENKADQYGIELTENREAAVKTFQDLAVTGLSQVDPP VLVKIFRGSHPSIMERIQHAEKEENAPEHQDADK*" /label="yhfN CDS" gene 1052681..1053961 /gene="yhfN" /locus_tag="BSU_10290" /old_locus_tag="BSU10290" /label="yhfN gene" promotor_-10 complement(1053108..1053127) /Source="Nicolas_upshift_promotors" /id="U829" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.574425574425574" /psig="0.974025974025974" /xcortree=1821 /SigmaFactorBS="tcagccaataaaaaacgagaacgcaaagcgtaaaGATTGGaa agctgatccaaaaGCTGATAACCTGATCCTTAGcccagctggccgttgtctgtgtgga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1053122) /Source="Nicolas_upshifts" /id="U829" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.574425574425574" /psig="0.974025974025974" /xcortree=1821 /SigmaFactorBS="tcagccaataaaaaacgagaacgcaaagcgtaaaGATTGGaa agctgatccaaaaGCTGATAACCTGATCCTTAGcccagctggccgttgtctgtgtgga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1053143..1053148) /Source="Nicolas_upshift_promotors" /id="U829" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.574425574425574" /psig="0.974025974025974" /xcortree=1821 /SigmaFactorBS="tcagccaataaaaaacgagaacgcaaagcgtaaaGATTGGaa agctgatccaaaaGCTGATAACCTGATCCTTAGcccagctggccgttgtctgtgtgga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1053948 /Source="Nicolas_upshifts" /id="D560" /incds=0 /nref=2 /ntot=57 /MaxReadThrough="3.82026" /MaxDrop="3.6342" /score="6.45541384" /energy="-12.7" /TU="U828" /idTUdmin="U828" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" downshifts complement(1053998) /Source="Nicolas_upshifts" /id="D561" /incds=0 /nref=129 /ntot=219 /MaxReadThrough="-0.11848" /MaxDrop="9.02627" /score="-6.76069514" /energy="-7.8" /TU="NA" /idTUdmin="U830" /TUdmin=4 /isTUend="TRUE" /label="downshifts" CDS complement(1054000..1055145) /gene="aprE" /locus_tag="BSU_10300" /old_locus_tag="BSU10300" /EC_number="3.4.21.62" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:3108260, 9811547, 12950930, 14688235, 15205417, 17666034, 19710937, 26728191" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3108260, 9811547, 12950930, 14688235, 15205417, 17666034, 19710937, 26728191; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="serine alkaline protease (Ca(2+)-dependent subtilisin E)" /protein_id="NP_388911.2" /db_xref="EnsemblGenomes-Gn:BSU10300" /db_xref="EnsemblGenomes-Tr:CAB12870" /db_xref="GOA:P04189" /db_xref="InterPro:IPR000209" /db_xref="InterPro:IPR009020" /db_xref="InterPro:IPR010259" /db_xref="InterPro:IPR015500" /db_xref="InterPro:IPR022398" /db_xref="InterPro:IPR023827" /db_xref="InterPro:IPR023828" /db_xref="InterPro:IPR034202" /db_xref="InterPro:IPR036852" /db_xref="InterPro:IPR037045" /db_xref="PDB:1SCJ" /db_xref="PDB:3WHI" /db_xref="SubtiList:BG10190" /db_xref="UniProtKB/Swiss-Prot:P04189" /translation="MRSKKLWISLLFALTLIFTMAFSNMSAQAAGKSSTEKKYIVGFK QTMSAMSSAKKKDVISEKGGKVQKQFKYVNAAAATLDEKAVKELKKDPSVAYVEEDHI AHEYAQSVPYGISQIKAPALHSQGYTGSNVKVAVIDSGIDSSHPDLNVRGGASFVPSE TNPYQDGSSHGTHVAGTIAALNNSIGVLGVAPSASLYAVKVLDSTGSGQYSWIINGIE WAISNNMDVINMSLGGPTGSTALKTVVDKAVSSGIVVAAAAGNEGSSGSTSTVGYPAK YPSTIAVGAVNSSNQRASFSSAGSELDVMAPGVSIQSTLPGGTYGAYNGTSMATPHVA GAAALILSKHPTWTNAQVRDRLESTATYLGNSFYYGKGLINVQAAAQ*" /label="aprE CDS" gene complement(1054000..1055145) /gene="aprE" /locus_tag="BSU_10300" /old_locus_tag="BSU10300" /label="aprE gene" S_feature complement(1055146..1055212) /Source="Nicolas_S_feature" /locus_tag="new_1105569_1105635_c" /HighExp="BC, T5.0H, LoTm, Sw, T4.0H, T3.30H, S1, T3.0H, S2, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S363" promotor_-10 complement(1055201..1055220) /Source="Nicolas_upshift_promotors" /id="U830" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=468 /SigmaFactorBS="atacctaaatagagataaaatcatctcaaaaaaatgggTCTA CtaaaatattattccaTCTATTACAATAAATTCACAgaatagtcttttaagtaagtct a" /listShort="S363, aprE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1055218) /Source="Nicolas_upshifts" /id="U830" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=468 /SigmaFactorBS="atacctaaatagagataaaatcatctcaaaaaaatgggTCTA CtaaaatattattccaTCTATTACAATAAATTCACAgaatagtcttttaagtaagtct a" /listShort="S363, aprE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1055236..1055240) /Source="Nicolas_upshift_promotors" /id="U830" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=468 /SigmaFactorBS="atacctaaatagagataaaatcatctcaaaaaaatgggTCTA CtaaaatattattccaTCTATTACAATAAATTCACAgaatagtcttttaagtaagtct a" /listShort="S363, aprE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1055525..1055532 /Source="Nicolas_upshift_promotors" /id="U831" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.854145854145854" /psig="0.983016983016983" /xcortree=2175 /SigmaFactorBS="ttcaaagcatgatgataaaagtattctgaaaaataaACTTTA CAgaaaagggatagaaTGAAAAAATTATTGAGAGGGaggaagaaataagatgaacatt c" /listShort="yhfO, yhfP, S364" /listLong="yhfQ" /label="promotor_-35" promotor_-10 1055547..1055566 /Source="Nicolas_upshift_promotors" /id="U831" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.854145854145854" /psig="0.983016983016983" /xcortree=2175 /SigmaFactorBS="ttcaaagcatgatgataaaagtattctgaaaaataaACTTTA CAgaaaagggatagaaTGAAAAAATTATTGAGAGGGaggaagaaataagatgaacatt c" /listShort="yhfO, yhfP, S364" /listLong="yhfQ" /label="promotor_-10" upshifts 1055549 /Source="Nicolas_upshifts" /id="U831" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.854145854145854" /psig="0.983016983016983" /xcortree=2175 /SigmaFactorBS="ttcaaagcatgatgataaaagtattctgaaaaataaACTTTA CAgaaaagggatagaaTGAAAAAATTATTGAGAGGGaggaagaaataagatgaacatt c" /listShort="yhfO, yhfP, S364" /listLong="yhfQ" /label="upshifts" CDS 1055580..1056029 /gene="yhfO" /locus_tag="BSU_10310" /old_locus_tag="BSU10310" /EC_number="2.3.1.-" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11717295; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_388912.1" /db_xref="EnsemblGenomes-Gn:BSU10310" /db_xref="EnsemblGenomes-Tr:CAB12871" /db_xref="GOA:O07614" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13059" /db_xref="UniProtKB/Swiss-Prot:O07614" /translation="MNIRQAKTSDAAAIAPLFNQYREFYRQASDLQGAEAFLKARLEN HESVILIAEENGEFIGFTQLYPTFSSVSMKRIYILNDLFVVPHARTKGAGGRLLSAAK DYAGQNGAKCLTLQTEHHNRKARSLYEQNGYEEDTGFVHYCLNVPAK*" /label="yhfO CDS" gene 1055580..1056029 /gene="yhfO" /locus_tag="BSU_10310" /old_locus_tag="BSU10310" /label="yhfO gene" promotor_-35 1056045..1056052 /Source="Nicolas_upshift_promotors" /id="U832" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2061 /SigmaFactorBS="tgtgccggcgaagtgaaaatggcggcttgatGATTTGGTttt ttgaacgttctTCGGTTACGATATAAATGAAaaggagtgtgccgaatgtcaacgttat t" /listShort="yhfP, S364, yhfQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1056067..1056086 /Source="Nicolas_upshift_promotors" /id="U832" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2061 /SigmaFactorBS="tgtgccggcgaagtgaaaatggcggcttgatGATTTGGTttt ttgaacgttctTCGGTTACGATATAAATGAAaaggagtgtgccgaatgtcaacgttat t" /listShort="yhfP, S364, yhfQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1056074 /Source="Nicolas_upshifts" /id="U832" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2061 /SigmaFactorBS="tgtgccggcgaagtgaaaatggcggcttgatGATTTGGTttt ttgaacgttctTCGGTTACGATATAAATGAAaaggagtgtgccgaatgtcaacgttat t" /listShort="yhfP, S364, yhfQ" /GFF_Attribute="listLong" /label="upshifts" CDS 1056101..1057093 /gene="yhfP" /locus_tag="BSU_10320" /old_locus_tag="BSU10320" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9643546, 12057962; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388913.1" /db_xref="EnsemblGenomes-Gn:BSU10320" /db_xref="EnsemblGenomes-Tr:CAB12872" /db_xref="GOA:O07615" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR014188" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="PDB:1TT7" /db_xref="PDB:1Y9E" /db_xref="SubtiList:BG13060" /db_xref="UniProtKB/Swiss-Prot:O07615" /translation="MSTLFQALQAEKNADDVSVHVKTISTEDLPKDGVLIKVAYSGIN YKDGLAGKAGGNIVREYPLILGIDAAGTVVSSNDPRFAEGDEVIATSYELGVSRDGGL SEYASVPGDWLVPLPQNLSLKEAMVYGTAGFTAALSVHRLEQNGLSPEKGSVLVTGAT GGVGGIAVSMLNKRGYDVVASTGNREAADYLKQLGASEVISREDVYDGTLKALSKQQW QGAVDPVGGKQLASLLSKIQYGGSVAVSGLTGGGEVPATVYPFILRGVSLLGIDSVYC PMDVRAAVWERMSSDLKPDQLLTIVDREVSLEETPGALKDILQNRIQGRVIVKL*" /label="yhfP CDS" gene 1056101..1057093 /gene="yhfP" /locus_tag="BSU_10320" /old_locus_tag="BSU10320" /label="yhfP gene" downshifts 1057094 /Source="Nicolas_upshifts" /id="D562" /incds=0 /nref=1 /ntot=37 /MaxReadThrough="4.4421" /MaxDrop="2.9095" /score="14.183693" /energy="-15.3" /TU="U831,U832" /idTUdmin="U831" /TUdmin="-154" /isTUend="FALSE" /label="downshifts" S_feature 1057139..1057249 /Source="Nicolas_S_feature" /locus_tag="new_1107562_1107672" /HighExp="Etha, dia15, LoTm, Salt, H2O2, LBGexp, Diami, Paraq, dia5, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.983" /TUlongSig="NA" /TUlongPSig="NA" /label="S364" promotor_-35 1057227..1057234 /Source="Nicolas_upshift_promotors" /id="U833" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.76023976023976" /psig=1 /xcortree=2107 /SigmaFactorBS="gtaagccgaactttctcttctcattttaaaaataatTGGTGA TAatgattctcattccgTGTTATACTACTCTTGGACAtcttaaccatagaaactacca a" /listShort="yhfQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1057250..1057269 /Source="Nicolas_upshift_promotors" /id="U833" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.76023976023976" /psig=1 /xcortree=2107 /SigmaFactorBS="gtaagccgaactttctcttctcattttaaaaataatTGGTGA TAatgattctcattccgTGTTATACTACTCTTGGACAtcttaaccatagaaactacca a" /listShort="yhfQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1057251 /Source="Nicolas_upshifts" /id="U833" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.76023976023976" /psig=1 /xcortree=2107 /SigmaFactorBS="gtaagccgaactttctcttctcattttaaaaataatTGGTGA TAatgattctcattccgTGTTATACTACTCTTGGACAtcttaaccatagaaactacca a" /listShort="yhfQ" /GFF_Attribute="listLong" /label="upshifts" CDS 1057310..1058281 /gene="yhfQ" /locus_tag="BSU_10330" /old_locus_tag="BSU10330" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12354229, 16672620, 20147287; Product type t: transporter" /codon_start=1 /transl_table=11 /product="iron(III) siderophore-binding lipoprotein" /protein_id="NP_388914.2" /db_xref="EnsemblGenomes-Gn:BSU10330" /db_xref="EnsemblGenomes-Tr:CAB12873" /db_xref="GOA:C0SP94" /db_xref="InterPro:IPR002491" /db_xref="SubtiList:BG13061" /db_xref="UniProtKB/Swiss-Prot:C0SP94" /translation="MKKTLIILTVLLLSVLTAACSSSSGNQNSKEHKVAVTHDLGKTN VPEHPKRVVVLELGFIDTLLDLGITPVGVADDNKAKQLINKDVLKKIDGYTSVGTRSQ PSMEKIASLKPDLIIADTTRHKKVYDQLKKIAPTIALNNLNADYQDTIDASLTIAKAV GKEKEMEKKLTAHEEKLSETKQKISANSQSVLLIGNTNDTIMARDENFFTSRLLTQVG YRYAISTSGNSDSSNGGDSVNMKMTLEQLLKTDPDVIILMTGKTDDLDADGKRPIEKN VLWKKLKAVKNGHVYHVDRAVWSLRRSVDGANAILDELQKEMPAAKK*" /label="yhfQ CDS" gene 1057310..1058281 /gene="yhfQ" /locus_tag="BSU_10330" /old_locus_tag="BSU10330" /label="yhfQ gene" downshifts 1058260 /Source="Nicolas_upshifts" /id="D563" /incds=0 /nref=172 /ntot=251 /MaxReadThrough="2.22013" /MaxDrop="5.6726" /score="27.9181244" /energy="-10.9" /TU="NA" /idTUdmin="U833" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1058313..1058894) /gene="phoE" /locus_tag="BSU_10340" /old_locus_tag="BSU10340" /EC_number="3.1.3.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10869096, 11827481, 12870714, 17693564" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10869096, 11827481, 12870714, 17693564; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous phosphatase; putative (phosphoglycerate) mutase" /protein_id="NP_388915.1" /db_xref="EnsemblGenomes-Gn:BSU10340" /db_xref="EnsemblGenomes-Tr:CAB12874" /db_xref="GOA:O07617" /db_xref="InterPro:IPR001345" /db_xref="InterPro:IPR013078" /db_xref="InterPro:IPR029033" /db_xref="SubtiList:BG13062" /db_xref="UniProtKB/Swiss-Prot:O07617" /translation="MTAVCLVRHGETDWNLQQKCQGKTDIPLNATGERQARETGEYVK DFSWDIIVTSPLKRAKRTAEIINEYLHLPIVEMDDFKERDYGDAEGMPLEERTKRYPD NIYPNMETLEELTDRLMGGLAKVNQAYPNKKVLIVAHGAAIHALLTEISGGDPELQST RLVNACLSNIEFAEEKWRIKDYNINSHLSGFIK*" /label="phoE CDS" gene complement(1058313..1058894) /gene="phoE" /locus_tag="BSU_10340" /old_locus_tag="BSU10340" /label="phoE gene" downshifts complement(1058336) /Source="Nicolas_upshifts" /id="D564" /incds=0 /nref=218 /ntot=256 /MaxReadThrough="1.23197" /MaxDrop="6.359" /score="28.9228703" /energy="-10.9" /TU="NA" /idTUdmin="U834" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1058918..1058937) /Source="Nicolas_upshift_promotors" /id="U834" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.370629370629371" /psig="0.998001998001998" /xcortree=1973 /SigmaFactorBS="ctttattatttgaagttcttgcataggctttttcATAGgaca cacgctttcgaTTTAGTATAATAGCGATATGaataaagtcaggaaggggattttatga c" /listShort="phoE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1058930) /Source="Nicolas_upshifts" /id="U834" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.370629370629371" /psig="0.998001998001998" /xcortree=1973 /SigmaFactorBS="ctttattatttgaagttcttgcataggctttttcATAGgaca cacgctttcgaTTTAGTATAATAGCGATATGaataaagtcaggaaggggattttatga c" /listShort="phoE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1058953..1058956) /Source="Nicolas_upshift_promotors" /id="U834" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.370629370629371" /psig="0.998001998001998" /xcortree=1973 /SigmaFactorBS="ctttattatttgaagttcttgcataggctttttcATAGgaca cacgctttcgaTTTAGTATAATAGCGATATGaataaagtcaggaaggggattttatga c" /listShort="phoE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1058965..1060059) /gene="yhfS" /locus_tag="BSU_10350" /old_locus_tag="BSU10350" /EC_number="2.3.1.9" /experiment="publication(s) with functional evidences, PMID:12368242, 23840410" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12368242, 23840410; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-CoA C-acetyltransferase" /protein_id="NP_388916.1" /db_xref="EnsemblGenomes-Gn:BSU10350" /db_xref="EnsemblGenomes-Tr:CAB12875" /db_xref="GOA:O07618" /db_xref="InterPro:IPR002155" /db_xref="InterPro:IPR016039" /db_xref="InterPro:IPR020613" /db_xref="InterPro:IPR020616" /db_xref="InterPro:IPR020617" /db_xref="SubtiList:BG13063" /db_xref="UniProtKB/Swiss-Prot:O07618" /translation="MNAVIVDAKRTIFGNQNGLLKPFLPEDLAAPIIRCLSRKLEDQV DEVILGNATGRGGNLARLSALQAGLPLSVPGMTIDRQCGSGLEAVRYACSLIQAGAGT MYIAGGSESSSQSPFSERARFSPDAIGDPDMGIAAEYTAARYSISRSMQDEYALLSHQ RSRNAHDEGFYREEVVALGELETDEAFLKTRPIEAIIPRAKPVFDTSSGTVTAANSSG IADGAAALLVMEEEKAAALGLKPVLRFIGSAVSGIHPNFPPAAPVVAIRQLLHTHDVT PDDIDLFEINEAFAVKICVCSQELGIPFSKINVRGGALALGHPYGASGAALVTRLFYE AKRRPDCQYAVAAIGSGGGIGLALLFEVLA*" /label="yhfS CDS" gene complement(1058965..1060059) /gene="yhfS" /locus_tag="BSU_10350" /old_locus_tag="BSU10350" /label="yhfS gene" CDS complement(1060056..1061495) /gene="yhfT" /locus_tag="BSU_10360" /old_locus_tag="BSU10360" /EC_number="6.2.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12368242, 28032445, 28414710; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative long-chain fatty-acid-CoA ligase (proofreading for biotin synthesis)" /protein_id="NP_388917.1" /db_xref="EnsemblGenomes-Gn:BSU10360" /db_xref="EnsemblGenomes-Tr:CAB12876" /db_xref="GOA:O07619" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="SubtiList:BG13064" /db_xref="UniProtKB/Swiss-Prot:O07619" /translation="MTITHTYSSTAETSPGRVAIQTESEQITYHDWDRLVSQTANWLR SQPSMPNRVAILLPNSLAFLQLFAGAAAAGCTAIPIDTRWSPAECKERLSISNADLVV TLAFFKNKLTDSQTPVVLLDNCMADISEAAADPLPTIDPEHPFYMGFTSGSTGKPKAF TRSHRSWMESFTCTETDFSISSDDKVLIPGALMSSHFLYGAVSTLFLGGTVCLLKKFS PAKAKEWLCRESISVLYTVPTMTDALARIEGFPDSPVKIISSGADWPAESKKKLAAAW PHLKLYDFYGTSELSFVTFSSPEDSKRKPHSAGRPFHNVRIEIRNAGGERCQPGEIGK IFVKSPMRFSGYVNGSTPDEWMTVDDMGYVDEEGFLYISGRENGMIVYGGLNIFPEEI ERVLLACPEVESAAVVGIPDEYWGEIAVAVILGNANARTLKAWCKQKLASYKIPKKWV FADSLPETSSGKIARSRVKKWLEESVQYK*" /label="yhfT CDS" gene complement(1060056..1061495) /gene="yhfT" /locus_tag="BSU_10360" /old_locus_tag="BSU10360" /label="yhfT gene" CDS complement(1061502..1062062) /gene="bioY" /locus_tag="BSU_10370" /old_locus_tag="BSU10370" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12368242, 15849754, 16850406, 18931129, 23709504; Product type t : transporter" /codon_start=1 /transl_table=11 /product="biotin transporter" /protein_id="NP_388918.1" /db_xref="EnsemblGenomes-Gn:BSU10370" /db_xref="EnsemblGenomes-Tr:CAB12877" /db_xref="GOA:O07620" /db_xref="InterPro:IPR003784" /db_xref="SubtiList:BG13065" /db_xref="UniProtKB/Swiss-Prot:O07620" /translation="MLKLIDMMHIAIFTALMAVLGFMPPLFLSFTPVPITLQTLGVML AGSILRPKSAFLSQLVFLLLVAFGAPLLPGGRGGFGVFFGPSAGFLIAYPLASWLISL AANRLRKVTVLRLFFTHIVFGIIFIYLLGIPVQAFIMHIDLSQAAFMSLAYVPGDLIK AAVSAFLAIKITQALSLSDTMFTKGG*" /label="bioY CDS" gene complement(1061502..1062062) /gene="bioY" /locus_tag="BSU_10370" /old_locus_tag="BSU10370" /label="bioY gene" misc_feature complement(1061512..1061531) /Source="Nicolas_upshift_promotors" /id="U835" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.585414585414585" /psig="0.97902097902098" /xcortree=2231 /SigmaFactorBS="aaaagcggctgtatctgcatttctggcgataaaaatcactca agccttgtctcttTCTGATACGATGTTTACAAAaggaggatgacaatacatgacaatt a" /listShort="yhfT, yhfS, phoE" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1061526) /Source="Nicolas_upshifts" /id="U835" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.585414585414585" /psig="0.97902097902098" /xcortree=2231 /SigmaFactorBS="aaaagcggctgtatctgcatttctggcgataaaaatcactca agccttgtctcttTCTGATACGATGTTTACAAAaggaggatgacaatacatgacaatt a" /listShort="yhfT, yhfS, phoE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1062087..1062106) /Source="Nicolas_upshift_promotors" /id="U836" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig="0.999000999001" /xcortree=2919 /SigmaFactorBS="ttgcgttcattatgtaaacttaaattaaaaatcAGTTGACAt aataattacctgcATTTATTGTATAACCATATTtgattactttttggaggatttcaca t" /listShort="bioY, yhfT, yhfS, phoE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1062101) /Source="Nicolas_upshifts" /id="U836" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig="0.999000999001" /xcortree=2919 /SigmaFactorBS="ttgcgttcattatgtaaacttaaattaaaaatcAGTTGACAt aataattacctgcATTTATTGTATAACCATATTtgattactttttggaggatttcaca t" /listShort="bioY, yhfT, yhfS, phoE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1062121..1062128) /Source="Nicolas_upshift_promotors" /id="U836" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig="0.999000999001" /xcortree=2919 /SigmaFactorBS="ttgcgttcattatgtaaacttaaattaaaaatcAGTTGACAt aataattacctgcATTTATTGTATAACCATATTtgattactttttggaggatttcaca t" /listShort="bioY, yhfT, yhfS, phoE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1062197..1063495) /gene="hemAT" /locus_tag="BSU_10380" /old_locus_tag="BSU10380" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11481493, 12657801, 12962628, 15033535, 16819829, 17003124, 22528495, 22564695" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11481493, 12657801, 12962628, 15033535, 16819829, 17003124, 22528495, 22564695; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="heme-based dioxygen sensor" /protein_id="NP_388919.1" /db_xref="EnsemblGenomes-Gn:BSU10380" /db_xref="EnsemblGenomes-Tr:CAB12878" /db_xref="GOA:O07621" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR009050" /db_xref="PDB:1OR4" /db_xref="PDB:1OR6" /db_xref="SubtiList:BG13066" /db_xref="UniProtKB/Swiss-Prot:O07621" /translation="MLFKKDRKQETAYFSDSNGQQKNRIQLTNKHADVKKQLKMVRLG DAELYVLEQLQPLIQENIVNIVDAFYKNLDHESSLMDIINDHSSVDRLKQTLKRHIQE MFAGVIDDEFIEKRNRIASIHLRIGLLPKWYMGAFQELLLSMIDIYEASITNQQELLK AIKATTKILNLEQQLVLEAFQSEYNQTRDEQEEKKNLLHQKIQETSGSIANLFSETSR SVQELVDKSEGISQASKAGTVTSSTVEEKSIGGKKELEVQQKQMNKIDTSLVQIEKEM VKLDEIAQQIEKIFGIVTGIAEQTNLLSLNASIESARAGEHGKGFAVVANEVRKLSED TKKTVSTVSELVNNTNTQINIVSKHIKDVNELVSESKEKMTQINRLFDEIVHSMKISK EQSGKIDVDLQAFLGGLQEVSRAVSHVAASVDSLVILTEE*" /label="hemAT CDS" gene complement(1062197..1063495) /gene="hemAT" /locus_tag="BSU_10380" /old_locus_tag="BSU10380" /label="hemAT gene" downshifts complement(1062208) /Source="Nicolas_upshifts" /id="D565" /incds=0 /nref=209 /ntot=243 /MaxReadThrough="2.70691" /MaxDrop="6.97357" /score="5.86442746" /energy="-6.9" /TU="NA" /idTUdmin="U837" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1063549..1063567) /Source="Nicolas_upshift_promotors" /id="U837" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2810 /SigmaFactorBS="tttttcaaatatttttcatctgcagCTTCATTcatgtttccc ttgGCCGATAAAAAAGAAAAAGgcttaaaaagccaaaaagtaaaaattatatttttcc c" /listShort="hemAT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1063552) /Source="Nicolas_upshifts" /id="U837" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2810 /SigmaFactorBS="tttttcaaatatttttcatctgcagCTTCATTcatgtttccc ttgGCCGATAAAAAAGAAAAAGgcttaaaaagccaaaaagtaaaaattatatttttcc c" /listShort="hemAT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1063581..1063587) /Source="Nicolas_upshift_promotors" /id="U837" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2810 /SigmaFactorBS="tttttcaaatatttttcatctgcagCTTCATTcatgtttccc ttgGCCGATAAAAAAGAAAAAGgcttaaaaagccaaaaagtaaaaattatatttttcc c" /listShort="hemAT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1063634..1065163) /gene="yhfW" /locus_tag="BSU_10390" /old_locus_tag="BSU10390" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase with Rieske [2Fe-2S] center" /protein_id="NP_388920.1" /db_xref="EnsemblGenomes-Gn:BSU10390" /db_xref="EnsemblGenomes-Tr:CAB12879" /db_xref="GOA:O07622" /db_xref="InterPro:IPR005805" /db_xref="InterPro:IPR006076" /db_xref="InterPro:IPR017941" /db_xref="InterPro:IPR036188" /db_xref="InterPro:IPR036922" /db_xref="SubtiList:BG13067" /db_xref="UniProtKB/Swiss-Prot:O07622" /translation="MANQHFAKEAPETYWKTSTDLPSFPALQEDTECDVTIIGGGITG ITTAYELTKRGFRVVLIEANQVLNGTTAHTTAKVTAQHDMIYDEFIRHFGLNHARLYY EANQNAIDYIKGIVDEHQIDCEWIEQDAYLYTANENAVQKIHTEHEAYTKLGIERDLI KDLPIPLGSKLALVMKNQAQFHPLQYLKALLEQIVQKGGRIYEETVALDIKKGERPEV VTKSRHAIKSRFIICCSHFPFYDGGGLYAARMYSDRSYVLAIKPKIEYPEGMYLSIDQ PSVALRYTVVNGEKLILFSGVSHKTGQGKAMSTHYETLRQLAESTIGIESIPYYWSTQ DLVTIDKIPFIGPMSENEDNILVATGFKKWGMTSSAVAATLLSDLVEKKENPYESIFT PSRFHLNPGLQKVISYNADVAKHLIKGKLEKPDVQFEDISPGEGKAVTINGRRAGAFR DETGCLHLVDTTCTHLGCEVEWNDSEHTWDCPCHGSRFKPSGEVVEGPAIKPLKQIDL D*" /label="yhfW CDS" gene complement(1063634..1065163) /gene="yhfW" /locus_tag="BSU_10390" /old_locus_tag="BSU10390" /label="yhfW gene" promotor_-10 complement(1065190..1065208) /Source="Nicolas_upshift_promotors" /id="U838" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.84015984015984" /psig="0.84015984015984" /xcortree=1075 /SigmaFactorBS="ttcaaccttattatgttatgaacaatgcctgcTTCCTAtgta tgaaaagataGAATATGGAAAAATTAAGAataaatctgattggaggtataacggcttg g" /listShort="yhfW, hemAT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1065200) /Source="Nicolas_upshifts" /id="U838" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.84015984015984" /psig="0.84015984015984" /xcortree=1075 /SigmaFactorBS="ttcaaccttattatgttatgaacaatgcctgcTTCCTAtgta tgaaaagataGAATATGGAAAAATTAAGAataaatctgattggaggtataacggcttg g" /listShort="yhfW, hemAT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1065219..1065224 /Source="Nicolas_upshift_promotors" /id="U839" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1100 /SigmaFactorBS="ccaatcagatttattcttaatttttccatattctatcttttc aTACATAggaagcaggcattgtTCATAACATAATAAGGTTGaaaaggagtgatttcat t" /listShort="yhxC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(1065223..1065228) /Source="Nicolas_upshift_promotors" /id="U838" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.84015984015984" /psig="0.84015984015984" /xcortree=1075 /SigmaFactorBS="ttcaaccttattatgttatgaacaatgcctgcTTCCTAtgta tgaaaagataGAATATGGAAAAATTAAGAataaatctgattggaggtataacggcttg g" /listShort="yhfW, hemAT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1065236 /Source="Nicolas_upshifts" /id="U839" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1100 /SigmaFactorBS="ccaatcagatttattcttaatttttccatattctatcttttc aTACATAggaagcaggcattgtTCATAACATAATAAGGTTGaaaaggagtgatttcat t" /listShort="yhxC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1065240..1065258 /Source="Nicolas_upshift_promotors" /id="U839" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1100 /SigmaFactorBS="ccaatcagatttattcttaatttttccatattctatcttttc aTACATAggaagcaggcattgtTCATAACATAATAAGGTTGaaaaggagtgatttcat t" /listShort="yhxC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1065275..1066132 /gene="yhxC" /locus_tag="BSU_10400" /old_locus_tag="BSU10400" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 18643936, 25720121; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388921.1" /db_xref="EnsemblGenomes-Gn:BSU10400" /db_xref="EnsemblGenomes-Tr:CAB12880" /db_xref="GOA:P40397" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11058" /db_xref="UniProtKB/Swiss-Prot:P40397" /translation="MANQKKKTLPPQHQNQQPGFEYLMDPRPVFDKPKKAKKLEGKTA IITGGDSGIGRAVSVLFAKEGANVVIVYLNEHQDAEETKQYVEKEGVKCLLIAGDVGD EAFCNDVVGQASQVFPSIDILVNNAAEQHVQPSIEKITSHQLIRTFQTNIFSMFYLTK AVLPHLKKGSSIINTASITAYKGNKTLIDYSATKGAIVTFTRSLSQSLVQQGIRVNAV APGPIWTPLIPASFAAKDVEVFGSDVPMERPGQPVEVAPSYLYLASDDSTYVTGQTIH VNGGTIVNG*" /label="yhxC CDS" gene 1065275..1066132 /gene="yhxC" /locus_tag="BSU_10400" /old_locus_tag="BSU10400" /label="yhxC gene" downshifts 1066114 /Source="Nicolas_upshifts" /id="D566" /incds=0 /nref=10 /ntot=36 /MaxReadThrough="2.65833" /MaxDrop="4.80135" /score="-8.69335909" /energy="-4.5" /TU="NA" /idTUdmin="U839" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1066160..1066393) /gene="yhzC" /locus_tag="BSU_10410" /old_locus_tag="BSU10410" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388922.1" /db_xref="EnsemblGenomes-Gn:BSU10410" /db_xref="EnsemblGenomes-Tr:CAB12881" /db_xref="InterPro:IPR014957" /db_xref="SubtiList:BG13087" /db_xref="UniProtKB/Swiss-Prot:O31594" /translation="MKEKKSYTELMKSRNTQKTKEFDVTMTDIYIQMVLDESLYNRRL AMLTDQINKALDEKDKDAFLTLSKEYAALKQSE*" /label="yhzC CDS" gene complement(1066160..1066393) /gene="yhzC" /locus_tag="BSU_10410" /old_locus_tag="BSU10410" /label="yhzC gene" downshifts complement(1066193) /Source="Nicolas_upshifts" /id="D567" /incds=0 /nref=191 /ntot=247 /MaxReadThrough="3.34616" /MaxDrop="7.00218" /score="21.4902337" /energy="-12.3" /TU="U841" /idTUdmin="U844" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1066410..1066429) /Source="Nicolas_upshift_promotors" /id="U841" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.914085914085914" /psig="0.999000999001" /xcortree=2872 /SigmaFactorBS="atagattgccaagtattagttgtctaaaaattataaaaattT ATTGATTttttcgaccgttatCCATATACTATAAAAAAGGCattggggggattcttta t" /listShort="yhzC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 1066413..1066414 /Source="Nicolas_upshift_promotors" /id="U840" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.422577422577423" /psig="0.422577422577423" /xcortree=1052 /SigmaFactorBS="cgggacttcatgagctcagtgtacgattttttctctttcata aagaatccccccaatgccTTttTTATAGTATATGGATAacggtcgaaaaaatcaataa a" /listShort="comK" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1066413 /Source="Nicolas_upshifts" /id="U840" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.422577422577423" /psig="0.422577422577423" /xcortree=1052 /SigmaFactorBS="cgggacttcatgagctcagtgtacgattttttctctttcata aagaatccccccaatgccTTttTTATAGTATATGGATAacggtcgaaaaaatcaataa a" /listShort="comK" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1066417..1066432 /Source="Nicolas_upshift_promotors" /id="U840" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.422577422577423" /psig="0.422577422577423" /xcortree=1052 /SigmaFactorBS="cgggacttcatgagctcagtgtacgattttttctctttcata aagaatccccccaatgccTTttTTATAGTATATGGATAacggtcgaaaaaatcaataa a" /listShort="comK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1066432) /Source="Nicolas_upshifts" /id="U841" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.914085914085914" /psig="0.999000999001" /xcortree=2872 /SigmaFactorBS="atagattgccaagtattagttgtctaaaaattataaaaattT ATTGATTttttcgaccgttatCCATATACTATAAAAAAGGCattggggggattcttta t" /listShort="yhzC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1066434..1067289) /Source="Nicolas_S_feature" /locus_tag="new_1116857_1117712_c" /HighExp="Salt, Etha, C30, Heat, S8, LPhT, Gly, C90, S7, UNK1" /AntisenseName="comK" /AntisenseCor="-5.68778941053006E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S365" promotor_-35 complement(1066444..1066451) /Source="Nicolas_upshift_promotors" /id="U841" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.914085914085914" /psig="0.999000999001" /xcortree=2872 /SigmaFactorBS="atagattgccaagtattagttgtctaaaaattataaaaattT ATTGATTttttcgaccgttatCCATATACTATAAAAAAGGCattggggggattcttta t" /listShort="yhzC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1066616..1066623 /Source="Nicolas_upshift_promotors" /id="U842" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.747252747252747" /psig="0.997002997002997" /xcortree=2958 /SigmaFactorBS="ttaaaagatgattttatcttaaatgttaaaaaaacCTGTCGT TttacaaaaacaGATGATAGATTATTAGTATAaattttgcagaaaaaggatggaggcc a" /listShort="comK, S366, S367" /listLong="yhjA" /label="promotor_-35" promotor_-10 1066635..1066654 /Source="Nicolas_upshift_promotors" /id="U842" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.747252747252747" /psig="0.997002997002997" /xcortree=2958 /SigmaFactorBS="ttaaaagatgattttatcttaaatgttaaaaaaacCTGTCGT TttacaaaaacaGATGATAGATTATTAGTATAaattttgcagaaaaaggatggaggcc a" /listShort="comK, S366, S367" /listLong="yhjA" /label="promotor_-10" upshifts 1066641 /Source="Nicolas_upshifts" /id="U842" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.747252747252747" /psig="0.997002997002997" /xcortree=2958 /SigmaFactorBS="ttaaaagatgattttatcttaaatgttaaaaaaacCTGTCGT TttacaaaaacaGATGATAGATTATTAGTATAaattttgcagaaaaaggatggaggcc a" /listShort="comK, S366, S367" /listLong="yhjA" /label="upshifts" CDS 1066686..1067264 /gene="comK" /locus_tag="BSU_10420" /old_locus_tag="BSU10420" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15743949, 15819619, 16554821, 16907804, 17468244, 26091431, 27501195, 27920766" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15743949, 15819619, 16554821, 16907804, 17468244, 26091431, 27501195, 27920766; Product type r: regulator" /codon_start=1 /transl_table=11 /product="competence transcription factor (CTF)" /protein_id="NP_388923.1" /db_xref="EnsemblGenomes-Gn:BSU10420" /db_xref="EnsemblGenomes-Tr:CAB12882" /db_xref="GOA:P40396" /db_xref="InterPro:IPR010461" /db_xref="SubtiList:BG11059" /db_xref="UniProtKB/Swiss-Prot:P40396" /translation="MSQKTDAPLESYEVNGATIAVLPEEIDGKICSKIIEKDCVFYVN MKPLQIVDRSCRFFGSSYAGRKAGTYEVTKISHKPPIMVDPSNQIFLFPTLSSTRPQC GWISHVHVKEFKATEFDDTEVTFSNGKTMELPISYNSFENQVYRTAWLRTKFQDRIDH RVPKRQEFMLYPKEERTKMIYDFILRELGERY*" /label="comK CDS" gene 1066686..1067264 /gene="comK" /locus_tag="BSU_10420" /old_locus_tag="BSU10420" /label="comK gene" S_feature 1067265..1067410 /Source="Nicolas_S_feature" /locus_tag="new_1117688_1117833" /HighExp="GM 150, C30, T-4.40H, T-3.40H, GM 120, M9-tran, T-2.40H, C90, G/S, T-1.10H" /AntisenseName="yhxD" /AntisenseCor="-0.229484184862048" /AntisenseRegPval="-3.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S366" CDS complement(1067311..1068210) /gene="yhxD" /locus_tag="BSU_10430" /old_locus_tag="BSU10430" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388924.1" /db_xref="EnsemblGenomes-Gn:BSU10430" /db_xref="EnsemblGenomes-Tr:CAB12883" /db_xref="GOA:P40398" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11060" /db_xref="UniProtKB/Swiss-Prot:P40398" /translation="MSDSNLTNPIKAFFHDEFPEQYQEPPGLQKNMKPVPDCGEKSYK GSGKLTGRKALVTGGDSGIGRAAAIAYAREGADVAINYLPEEQPDAEEVKELIEAEGR KAVLIPGDLSDESFCQDLVKQSHHELGGLDVLALVAGKQQAVENIEDLPTEQIYKTFE VNVFSLYWVVKAALPYLPEGASIITTTSVEGYNPSPMLLDYAATKNAIIGFTVGLGKQ LASKGIRVNSVAPGPIWTPLQISGGQPTENIPKFGQGTPPAPLNRAGQPVELADVYVF LASENSSYVTSQVYGITGGIPTA*" /label="yhxD CDS" gene complement(1067311..1068210) /gene="yhxD" /locus_tag="BSU_10430" /old_locus_tag="BSU10430" /label="yhxD gene" downshifts complement(1067334) /Source="Nicolas_upshifts" /id="D568" /incds=0 /nref=7 /ntot=53 /MaxReadThrough="4.95535" /MaxDrop="4.1467" /score="-2.68458203" /energy="-14.6" /TU="U844" /idTUdmin="U844" /TUdmin="-1144" /isTUend="FALSE" /label="downshifts" promotor_-35 1067397..1067400 /Source="Nicolas_upshift_promotors" /id="U843" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95104895104895" /psig="0.010989010989011" /xcortree=17 /SigmaFactorBS="atgtcacatagcttgaattctctgaagctagaaatacataaa catCGGCcaattccactggctgccCAGCGcgatttaatggagctggcggcgtgccttg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1067412 /Source="Nicolas_upshifts" /id="U843" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95104895104895" /psig="0.010989010989011" /xcortree=17 /SigmaFactorBS="atgtcacatagcttgaattctctgaagctagaaatacataaa catCGGCcaattccactggctgccCAGCGcgatttaatggagctggcggcgtgccttg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1067418..1067422 /Source="Nicolas_upshift_promotors" /id="U843" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95104895104895" /psig="0.010989010989011" /xcortree=17 /SigmaFactorBS="atgtcacatagcttgaattctctgaagctagaaatacataaa catCGGCcaattccactggctgccCAGCGcgatttaatggagctggcggcgtgccttg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 1067456 /Source="Nicolas_upshifts" /id="D569" /incds=1 /nref=1 /ntot=5 /MaxReadThrough="5.45904" /MaxDrop="5.6543" /score="-8.69335909" /energy="-4.5" /TU="U842" /idTUdmin="U843" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1067501..1068367 /Source="Nicolas_S_feature" /locus_tag="new_1117924_1118790" /HighExp="GM 150, C30, T-4.40H, C90, T-3.40H, T-2.40H, G/S, T-5.40H, M9-tran, nit" /AntisenseName="yhxD" /AntisenseCor="-0.32746434250834699" /AntisenseRegPval="-7.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S367" promotor_-10 complement(1068237..1068255) /Source="Nicolas_upshift_promotors" /id="U844" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=190 /SigmaFactorBS="tgttttctttttccttcactattcaaactgccaaaacaTGTT TTTctgcttatgctcagGGGTACACATACGAATGTAcaccaaacagaaaaggagcgtt g" /listShort="yhxD, S365, yhzC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1068254) /Source="Nicolas_upshifts" /id="U844" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=190 /SigmaFactorBS="tgttttctttttccttcactattcaaactgccaaaacaTGTT TTTctgcttatgctcagGGGTACACATACGAATGTAcaccaaacagaaaaggagcgtt g" /listShort="yhxD, S365, yhzC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1068270..1068276) /Source="Nicolas_upshift_promotors" /id="U844" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=190 /SigmaFactorBS="tgttttctttttccttcactattcaaactgccaaaacaTGTT TTTctgcttatgctcagGGGTACACATACGAATGTAcaccaaacagaaaaggagcgtt g" /listShort="yhxD, S365, yhzC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1068344..1068351 /Source="Nicolas_upshift_promotors" /id="U845" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.866133866133866" /psig=1 /xcortree=2715 /SigmaFactorBS="aaaacaagaaaaaacaaagccttcttccatatttaTCTTGTC AaataagactatatgAATTATGATAAATTCGAGCTataaatcaactaaatattgggtg t" /listShort="yhjA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1068366..1068385 /Source="Nicolas_upshift_promotors" /id="U845" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.866133866133866" /psig=1 /xcortree=2715 /SigmaFactorBS="aaaacaagaaaaaacaaagccttcttccatatttaTCTTGTC AaataagactatatgAATTATGATAAATTCGAGCTataaatcaactaaatattgggtg t" /listShort="yhjA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1068369 /Source="Nicolas_upshifts" /id="U845" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.866133866133866" /psig=1 /xcortree=2715 /SigmaFactorBS="aaaacaagaaaaaacaaagccttcttccatatttaTCTTGTC AaataagactatatgAATTATGATAAATTCGAGCTataaatcaactaaatattgggtg t" /listShort="yhjA" /GFF_Attribute="listLong" /label="upshifts" CDS 1068427..1068696 /gene="yhjA" /locus_tag="BSU_10440" /old_locus_tag="BSU10440" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388925.1" /db_xref="EnsemblGenomes-Gn:BSU10440" /db_xref="EnsemblGenomes-Tr:CAB12884" /db_xref="InterPro:IPR008613" /db_xref="SubtiList:BG13068" /db_xref="UniProtKB/Swiss-Prot:O07555" /translation="MKKAAAVLLSLGLVFGFSYGAGHVAEAKTKVKVYKNCKELNKVY KGGVARTSKVKNKGGKTKYKPYVSKALYDANKNKDRDKDLIACER*" /label="yhjA CDS" gene 1068427..1068696 /gene="yhjA" /locus_tag="BSU_10440" /old_locus_tag="BSU10440" /label="yhjA gene" downshifts 1068688 /Source="Nicolas_upshifts" /id="D570" /incds=0 /nref=230 /ntot=267 /MaxReadThrough="2.67325" /MaxDrop="7.59695" /score="27.4895724" /energy="-11.2" /TU="NA" /idTUdmin="U845" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1068736) /Source="Nicolas_upshifts" /id="D571" /incds=0 /nref=11 /ntot=113 /MaxReadThrough="2.40747" /MaxDrop="4.60953" /score="20.2036192" /energy="-11.2" /TU="NA" /idTUdmin="U846" /TUdmin=6 /isTUend="TRUE" /label="downshifts" CDS complement(1068739..1070208) /gene="yhjB" /locus_tag="BSU_10450" /old_locus_tag="BSU10450" /function="16.1: Circulate" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16267290, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na+/metabolite cotransporter" /protein_id="NP_388926.1" /db_xref="EnsemblGenomes-Gn:BSU10450" /db_xref="EnsemblGenomes-Tr:CAB12885" /db_xref="GOA:O07556" /db_xref="InterPro:IPR001734" /db_xref="SubtiList:BG13069" /db_xref="UniProtKB/Swiss-Prot:O07556" /translation="MNAALIIIFGVLLLSIFLGIRAQKGKDMNLEQWTVGGRGFGTVF VFLLMAGEIYTTFTFLGGSGWAYGKGGPAFYIIAYGCLAYILSYWLLPAVWTYAKQHK LMSQSDFFTKKYNSPLLGILVSLVGIAALIPYLVLQLKGLGLIVSETSYGKITPTAAI WIGAVSITVYVMVSGIHGSAWISVVKDIMILVVVLFLGVYLPIHYYGGFQDMFQQIET AKPGFLTLPESGQSVAWFSSTVLLTALGFYMWPHTFSASYSAENPKVFRKNAIIMPLY QLVLLFVLFVGFAAILQVPDLNGADGDLSLLRLSLQAFDPWFVGIIGAAGLLTALVPG SMILMSASTLFAKNVYKVIAPRTTEQQVSALAKFLVPVIALISVYFTFKGGNTIVTLL LMGYSLVTQLFPALLFSLLKHNMVTKQGAFAGIIAGVGAVTYITMTETTIGTLFPALP QAAKDLNVGIVALLLNITVMMAVSLMTRKAKSAAADQAA*" /label="yhjB CDS" gene complement(1068739..1070208) /gene="yhjB" /locus_tag="BSU_10450" /old_locus_tag="BSU10450" /label="yhjB gene" CDS complement(1070205..1070405) /gene="yhjC" /locus_tag="BSU_10460" /old_locus_tag="BSU10460" /function="16.1: Circulate" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16267290; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_388927.1" /db_xref="EnsemblGenomes-Gn:BSU10460" /db_xref="EnsemblGenomes-Tr:CAB12886" /db_xref="GOA:O07557" /db_xref="InterPro:IPR021741" /db_xref="SubtiList:BG13070" /db_xref="UniProtKB/Swiss-Prot:O07557" /translation="MKLIHVLAALPFIGILLGIPFANKVTPYVFGMPFILAYIVMWAL LTSALMAIVYVLDKENKKEEAE*" /label="yhjC CDS" gene complement(1070205..1070405) /gene="yhjC" /locus_tag="BSU_10460" /old_locus_tag="BSU10460" /label="yhjC gene" S_feature complement(1070406..1070524) /Source="Nicolas_S_feature" /locus_tag="new_1120829_1120947_c" /HighExp="S1, Etha, HiOs, MG 120, LoTm, T-5.40H, S2, GM-0.1, GM-0.2, T0.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S368" promotor_-10 complement(1070507..1070526) /Source="Nicolas_upshift_promotors" /id="U846" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.574425574425574" /psig=1 /xcortree=2904 /SigmaFactorBS="cttcgggcgattcagagcattaatttcagacaattcacACTA TACAaacaaaataaatTTATTTATAATTCGAACCACagcctttcactccaaaaaatga c" /listShort="S368, yhjC, yhjB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1070524) /Source="Nicolas_upshifts" /id="U846" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.574425574425574" /psig=1 /xcortree=2904 /SigmaFactorBS="cttcgggcgattcagagcattaatttcagacaattcacACTA TACAaacaaaataaatTTATTTATAATTCGAACCACagcctttcactccaaaaaatga c" /listShort="S368, yhjC, yhjB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1070539..1070546) /Source="Nicolas_upshift_promotors" /id="U846" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.574425574425574" /psig=1 /xcortree=2904 /SigmaFactorBS="cttcgggcgattcagagcattaatttcagacaattcacACTA TACAaacaaaataaatTTATTTATAATTCGAACCACagcctttcactccaaaaaatga c" /listShort="S368, yhjC, yhjB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1070612) /Source="Nicolas_upshifts" /id="D572" /incds=0 /nref=1 /ntot=8 /MaxReadThrough="3.99656" /MaxDrop="2.67326" /score="20.2036192" /energy="-11.2" /TU="U848" /idTUdmin="U848" /TUdmin="-374" /isTUend="FALSE" /label="downshifts" CDS complement(1070613..1070975) /gene="yhjD" /locus_tag="BSU_10470" /old_locus_tag="BSU10470" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16267290" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388928.1" /db_xref="EnsemblGenomes-Gn:BSU10470" /db_xref="EnsemblGenomes-Tr:CAB12887" /db_xref="GOA:O07558" /db_xref="SubtiList:BG13071" /db_xref="UniProtKB/Swiss-Prot:O07558" /translation="MPNLQEEIYDLIERALFLPMAITIFNRDLAGIEESTLKLKHPYK QLISESLKIAQKDLMEVRKELRKRKIAIRETERDEAFTLYTFVIDGYEENHRYFNPRI REQVSELLTYYLFAPDRL*" /label="yhjD CDS" gene complement(1070613..1070975) /gene="yhjD" /locus_tag="BSU_10470" /old_locus_tag="BSU10470" /label="yhjD gene" promotor_-35 1070813..1070818 /Source="Nicolas_upshift_promotors" /id="U847" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.963036963036963" /psig="0.963036963036963" /xcortree=1144 /SigmaFactorBS="tttcctcagttcttttctgacctccatcaaatccttttGTGC TAtttttaatgattcgcTGATAAGCTGTTTATAAGGatgcttcaattttaatgtgctt t" /listShort="S369, yhjE, sipV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1070834..1070852 /Source="Nicolas_upshift_promotors" /id="U847" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.963036963036963" /psig="0.963036963036963" /xcortree=1144 /SigmaFactorBS="tttcctcagttcttttctgacctccatcaaatccttttGTGC TAtttttaatgattcgcTGATAAGCTGTTTATAAGGatgcttcaattttaatgtgctt t" /listShort="S369, yhjE, sipV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1070835 /Source="Nicolas_upshifts" /id="U847" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.963036963036963" /psig="0.963036963036963" /xcortree=1144 /SigmaFactorBS="tttcctcagttcttttctgacctccatcaaatccttttGTGC TAtttttaatgattcgcTGATAAGCTGTTTATAAGGatgcttcaattttaatgtgctt t" /listShort="S369, yhjE, sipV" /GFF_Attribute="listLong" /label="upshifts" S_feature 1070844..1071083 /Source="Nicolas_S_feature" /locus_tag="new_1121267_1121506" /HighExp="S6, S4, S8, S5, LoTm, B36, S3, S7, BT, B60" /AntisenseName="yhjD" /AntisenseCor="0.24202608585419999" /AntisenseRegPval="-4.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.963" /TUlongSig="NA" /TUlongPSig="NA" /label="S369" promotor_-10 complement(1071005..1071024) /Source="Nicolas_upshift_promotors" /id="U848" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.975024975024975" /psig="0.999000999001" /xcortree=1502 /SigmaFactorBS="tcagcagaaaactaaaaagttttggtgattttttctgTCTTG AAAcatttcaccagccgATATAGAATACAAATAGAACaaacgttcccttagaaagaag g" /listShort="yhjD, S368, yhjC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1071023) /Source="Nicolas_upshifts" /id="U848" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.975024975024975" /psig="0.999000999001" /xcortree=1502 /SigmaFactorBS="tcagcagaaaactaaaaagttttggtgattttttctgTCTTG AAAcatttcaccagccgATATAGAATACAAATAGAACaaacgttcccttagaaagaag g" /listShort="yhjD, S368, yhjC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1071039..1071046) /Source="Nicolas_upshift_promotors" /id="U848" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.975024975024975" /psig="0.999000999001" /xcortree=1502 /SigmaFactorBS="tcagcagaaaactaaaaagttttggtgattttttctgTCTTG AAAcatttcaccagccgATATAGAATACAAATAGAACaaacgttcccttagaaagaag g" /listShort="yhjD, S368, yhjC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1071065..1071072 /Source="Nicolas_upshift_promotors" /id="U849" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.711288711288711" /psig="0.998001998001998" /xcortree=619 /SigmaFactorBS="cggctggtgaaatgtttcaagacagaaaaaatcaccaaaaCT TTTTAGttttctgctgataATGTGTAGAATAAGGATAGAcaaacccggtaaggagtat a" /listShort="yhjE, sipV" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1071085 /Source="Nicolas_upshifts" /id="U849" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.711288711288711" /psig="0.998001998001998" /xcortree=619 /SigmaFactorBS="cggctggtgaaatgtttcaagacagaaaaaatcaccaaaaCT TTTTAGttttctgctgataATGTGTAGAATAAGGATAGAcaaacccggtaaggagtat a" /listShort="yhjE, sipV" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1071086..1071105 /Source="Nicolas_upshift_promotors" /id="U849" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.711288711288711" /psig="0.998001998001998" /xcortree=619 /SigmaFactorBS="cggctggtgaaatgtttcaagacagaaaaaatcaccaaaaCT TTTTAGttttctgctgataATGTGTAGAATAAGGATAGAcaaacccggtaaggagtat a" /listShort="yhjE, sipV" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1071127..1071750 /gene="yhjE" /locus_tag="BSU_10480" /old_locus_tag="BSU10480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_388929.1" /db_xref="EnsemblGenomes-Gn:BSU10480" /db_xref="EnsemblGenomes-Tr:CAB12888" /db_xref="GOA:O07559" /db_xref="InterPro:IPR015414" /db_xref="InterPro:IPR032816" /db_xref="SubtiList:BG13072" /db_xref="UniProtKB/Swiss-Prot:O07559" /translation="MLEHFLSYLTQEHLTELFQSYRAFGPLIAVLLPLIEAFLPFLPL IVFVVANTNSFGLWEGFILSWAGSTAGSILVFLIVRQYGQRKLLGFIRSHPSVRKLML WVERHGFGPMFLLLCFPFTPSAAVNVVAGLSRIGTRPFILAAASGKLVMIFMISFIGY DLHALITQPIRTVIAVLVITVLWYVGKKVERYLHVRASQREHDGGRQ*" /label="yhjE CDS" gene 1071127..1071750 /gene="yhjE" /locus_tag="BSU_10480" /old_locus_tag="BSU10480" /label="yhjE gene" CDS 1071752..1072258 /gene="sipV" /locus_tag="BSU_10490" /old_locus_tag="BSU10490" /EC_number="3.4.21.89" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9325333, 9694797, 11309398, 12897006, 14568161, 27159567" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9325333, 9694797, 11309398, 12897006, 14568161, 27159567; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="type I signal peptidase" /protein_id="NP_388930.1" /db_xref="EnsemblGenomes-Gn:BSU10490" /db_xref="EnsemblGenomes-Tr:CAB12889" /db_xref="GOA:O07560" /db_xref="InterPro:IPR000223" /db_xref="InterPro:IPR015927" /db_xref="InterPro:IPR019756" /db_xref="InterPro:IPR019757" /db_xref="InterPro:IPR019758" /db_xref="InterPro:IPR036286" /db_xref="SubtiList:BG12674" /db_xref="UniProtKB/Swiss-Prot:O07560" /translation="MKKRFWFLAGVVSVVLAIQVKNAVFIDYKVEGVSMNPTFQEGNE LLVNKFSHRFKTIHRFDIVLFKGPDHKVLIKRVIGLPGETIKYKDDQLYVNGKQVAEP FLKHLKSVSAGSHVTGDFSLKDVTGTSKVPKGKYFVVGDNRIYSFDSRHFGPIREKNI VGVISDAE*" /label="sipV CDS" gene 1071752..1072258 /gene="sipV" /locus_tag="BSU_10490" /old_locus_tag="BSU10490" /label="sipV gene" downshifts 1072251 /Source="Nicolas_upshifts" /id="D573" /incds=0 /nref=131 /ntot=250 /MaxReadThrough="0.63331" /MaxDrop="4.58282" /score="-7.37718733" /energy="-7.1" /TU="NA" /idTUdmin="U847" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1072309..1072316 /Source="Nicolas_upshift_promotors" /id="U850" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.662337662337662" /psig=1 /xcortree=2713 /SigmaFactorBS="cgtctttttgtatgccgtttggaaaaatgtGTTGAAGAaaaa tttgtaaggAGCTATAATCAAAATTGTTAcctgtgtaacaaaatttatatattttttt g" /listShort="S370, yhjG, yhjH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1072330..1072349 /Source="Nicolas_upshift_promotors" /id="U850" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.662337662337662" /psig=1 /xcortree=2713 /SigmaFactorBS="cgtctttttgtatgccgtttggaaaaatgtGTTGAAGAaaaa tttgtaaggAGCTATAATCAAAATTGTTAcctgtgtaacaaaatttatatattttttt g" /listShort="S370, yhjG, yhjH" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1072339..1072438 /Source="Nicolas_S_feature" /locus_tag="new_1122762_1122861" /HighExp="LBGstat, LBGexp, Lbtran, C90, dia0, Lbexp, HPh, dia5, aero, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S370" upshifts 1072339 /Source="Nicolas_upshifts" /id="U850" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.662337662337662" /psig=1 /xcortree=2713 /SigmaFactorBS="cgtctttttgtatgccgtttggaaaaatgtGTTGAAGAaaaa tttgtaaggAGCTATAATCAAAATTGTTAcctgtgtaacaaaatttatatattttttt g" /listShort="S370, yhjG, yhjH" /GFF_Attribute="listLong" /label="upshifts" CDS 1072439..1073938 /gene="yhjG" /locus_tag="BSU_10500" /old_locus_tag="BSU10500" /EC_number="1.14.13.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7678243, 15121720; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aromatic compound monooxygenase/hydroxylase" /protein_id="NP_388931.1" /db_xref="EnsemblGenomes-Gn:BSU10500" /db_xref="EnsemblGenomes-Tr:CAB12890" /db_xref="GOA:O07561" /db_xref="InterPro:IPR002938" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG13073" /db_xref="UniProtKB/Swiss-Prot:O07561" /translation="MMMKYEAVIIGGGPVGFMLASELAIAGVGTCVIERLEKPVPHSK ALTLHPRTLELLEMRGILERFVSKGSKIPTGHFSMLDTRLDFSGLDTSCPYTLLLPQS KTEKLLEDHARSLGTEVFRGAEALAVTQNGEAVQTIFKDRDGSVRTITSKFAVGADGA GSTVRKQAKIEFPGTDSTVTAALGDVVLLSPPPSGVLSLCTKEGGVMIVPLSPDRYRV VVISPYRTQTPKDVPVTEEELKADLLRICGTDFGLTDPSWMSRFGNAARQAKRYRDGR IFLAGDAAHIHFPAGGQGLNVGLQDAMNLGWKLAAAIKGSAPSWLLDSYHDERHPAAE GLLRNTEAQTKLIDFTQAGLHLRSMMSELLAFPDVNRYVAGQISALDVRYEADRTMPP NRLNGARLPDMKLILSDGNSERLYSFLQNGTFVLLSLRQEADDHIEVKGLRTVTASLA EPNEKLRNVHTILIRPDGHVAWAVDASAPDCSEVIQKGISRWFSVTSRV*" /label="yhjG CDS" gene 1072439..1073938 /gene="yhjG" /locus_tag="BSU_10500" /old_locus_tag="BSU10500" /label="yhjG gene" promotor_-35 1073946..1073953 /Source="Nicolas_upshift_promotors" /id="U851" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig=1 /xcortree=1955 /SigmaFactorBS="cagccgctggttttccgtcaccagccgagtataattcaattC GATTGTTtcatctgtaacaaAACGGTATGATAGAAGAAACaatcgaatgaaaaaggat g" /listShort="yhjH" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1073965 /Source="Nicolas_upshifts" /id="U851" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig=1 /xcortree=1955 /SigmaFactorBS="cagccgctggttttccgtcaccagccgagtataattcaattC GATTGTTtcatctgtaacaaAACGGTATGATAGAAGAAACaatcgaatgaaaaaggat g" /listShort="yhjH" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1073967..1073986 /Source="Nicolas_upshift_promotors" /id="U851" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig=1 /xcortree=1955 /SigmaFactorBS="cagccgctggttttccgtcaccagccgagtataattcaattC GATTGTTtcatctgtaacaaAACGGTATGATAGAAGAAACaatcgaatgaaaaaggat g" /listShort="yhjH" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1074015..1074542 /gene="yhjH" /locus_tag="BSU_10510" /old_locus_tag="BSU10510" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_388932.1" /db_xref="EnsemblGenomes-Gn:BSU10510" /db_xref="EnsemblGenomes-Tr:CAB12891" /db_xref="GOA:Q796S4" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13074" /db_xref="UniProtKB/Swiss-Prot:Q796S4" /translation="MNTDHTKRNLFELYAELIHQQEKWEGLIKAFLSDELRKLDVEHG SKSQLTMTEIHVLSCVGDNEPINVTSIAEKMNTTKATVSRISTKLLGAGFLHRTQLSD NKKEVYFRLTPAGKKLHSLHKYYHQKAEQRFLSFFDRYTEEEILFAERLFRDLVTKWY PSSEEIEGGLPSIFK*" /label="yhjH CDS" gene 1074015..1074542 /gene="yhjH" /locus_tag="BSU_10510" /old_locus_tag="BSU10510" /label="yhjH gene" downshifts 1074504 /Source="Nicolas_upshifts" /id="D574" /incds=0 /nref=8 /ntot=128 /MaxReadThrough="1.1509" /MaxDrop="3.41655" /score="11.3050978" /energy="-9.9" /TU="NA" /idTUdmin="U851" /TUdmin=8 /isTUend="TRUE" /label="downshifts" S_feature complement(1074556..1074699) /Source="Nicolas_S_feature" /locus_tag="new_1124979_1125122_c" /HighExp="B36, B60, T0.30H, LBGstat, T1.30H, T1.0H, LPhT, LBGtran, Diami, T-0.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.979" /TUlongSig="NA" /TUlongPSig="NA" /label="S371" downshifts complement(1074594) /Source="Nicolas_upshifts" /id="D575" /incds=0 /nref=4 /ntot=72 /MaxReadThrough="1.20458" /MaxDrop="5.06167" /score="27.254423" /energy="-9.9" /TU="NA" /idTUdmin="U855" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1074700..1075905) /gene="glcP" /locus_tag="BSU_10520" /old_locus_tag="BSU10520" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9457850, 15849754, 16850406, 17056753, 19087206" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9457850, 15849754, 16850406, 17056753, 19087206; Product type t : transporter" /codon_start=1 /transl_table=11 /product="glucose/mannose:H+ symporter (recent HGT island)" /protein_id="NP_388933.1" /db_xref="EnsemblGenomes-Gn:BSU10520" /db_xref="EnsemblGenomes-Tr:CAB12892" /db_xref="GOA:O07563" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13075" /db_xref="UniProtKB/Swiss-Prot:O07563" /translation="MLRGTYLFGYAFFFTVGIIHISTGSLTPFLLEAFNKTTDDISVI IFFQFTGFLSGVLIAPLMIKKYSHFRTLTLALTIMLVALSIFFLTKDWYYIIVMAFLL GYGAGTLETTVGSFVIANFESNAEKMSKLEVLFGLGALSFPLLINSFIDINNWFLPYY CIFTFLFVLFVGWLIFLSKNREYAKNANQQVTFPDGGAFQYFIGDRKKSKQLGFFVFF AFLYAGIETNFANFLPSIMINQDNEQISLISVSFFWVGIIIGRILIGFVSRRLDFSKY LLFSCSCLIVLLIAFSYISNPILQLSGTFLIGLSIAGIFPIALTLASIIIQKYVDEVT SLFIASASFGGAIISFLIGWSLNQDTILLTMGIFTTMAVILVGISVKIRRTKTEDPIS LENKASKTQ*" /label="glcP CDS" gene complement(1074700..1075905) /gene="glcP" /locus_tag="BSU_10520" /old_locus_tag="BSU10520" /label="glcP gene" promotor_-35 1075395..1075400 /Source="Nicolas_upshift_promotors" /id="U852" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1194 /SigmaFactorBS="tctcggttcttagacaagaaaattaaccaccctaCGAATAgg acgaataaaaaggtGAATATACAGTAATATGGTaaaaaccagttattgatatctatga a" /listShort="S372" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1075417..1075435 /Source="Nicolas_upshift_promotors" /id="U852" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1194 /SigmaFactorBS="tctcggttcttagacaagaaaattaaccaccctaCGAATAgg acgaataaaaaggtGAATATACAGTAATATGGTaaaaaccagttattgatatctatga a" /listShort="S372" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1075420..1075946 /Source="Nicolas_S_feature" /locus_tag="new_1125843_1126369" /HighExp="S4, S5, S6, S8, S7, S3, T5.0H, M9-stat, LBGstat, T4.0H" /AntisenseName="glcP" /AntisenseCor="-0.155079396671681" /AntisenseRegPval="-2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S372" upshifts 1075421 /Source="Nicolas_upshifts" /id="U852" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1194 /SigmaFactorBS="tctcggttcttagacaagaaaattaaccaccctaCGAATAgg acgaataaaaaggtGAATATACAGTAATATGGTaaaaaccagttattgatatctatga a" /listShort="S372" /GFF_Attribute="listLong" /label="upshifts" downshifts 1075904 /Source="Nicolas_upshifts" /id="D576" /incds=0 /nref=6 /ntot=59 /MaxReadThrough="2.40974" /MaxDrop="3.26024" /score="9.68585629" /energy="-9.4" /TU="NA" /idTUdmin="U852" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1075977..1077029) /gene="ntdC" /locus_tag="BSU_10530" /old_locus_tag="BSU10530" /EC_number="1.1.1.-" /function="16.8: Protect" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14612444, 17056753, 23586652, 28353336" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14612444, 17056753, 23586652, 28353336; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="biosynthesis of neotrehalosadiamine (3,3'-diamino-3,3'-dideoxy-alpha,beta-trehalose), glucose-6-P 3-dehydrogenase; kanosamine biosynthesis (recent HGT island)" /protein_id="NP_388934.2" /db_xref="EnsemblGenomes-Gn:BSU10530" /db_xref="EnsemblGenomes-Tr:CAB12893" /db_xref="GOA:O07564" /db_xref="InterPro:IPR000683" /db_xref="InterPro:IPR004104" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13076" /db_xref="UniProtKB/Swiss-Prot:O07564" /translation="MKKIGIIGAGGIARAHATALSTIKNAELVGVYDINQQNAESFVK TFGGKSFENVDELIDASEGLIVASPNFCHKEHALQALGKHKHVLCEKPMAISLEEASI MKDTAERLSVRASMGFNYRYLSYVNILKSLIINNELGNILSIKVHFKKNSALRRKKFT WRDDANSKKTSGSLGDLGIHLIDMVWYLFESDFITESVRAKMNTNVKTKEDKQVLVDD YAEIYGQLKNKVFVNIITSKCSVPEDCGFSIEVVGHKKEFKYHTGNPHVYKLIDGLNV VDCPVPQSLLNDPPNEFYGWADSFRSELINWIASTQNDWVEIPSFSDGFRSQEVLEMF FEKDSNSQPMSVSAVN*" /label="ntdC CDS" gene complement(1075977..1077029) /gene="ntdC" /locus_tag="BSU_10530" /old_locus_tag="BSU10530" /label="ntdC gene" CDS complement(1077043..1077891) /gene="ntdB" /locus_tag="BSU_10540" /old_locus_tag="BSU10540" /EC_number="3.-.-.-" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14612444, 17056753, 23586652" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14612444, 17056753, 23586652; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="biosynthesis of neotrehalosadiamine (3,3'-diamino-3,3'-dideoxy-alpha, beta-trehalose);kanosamine-6-phosphate phosphatase (recent HGT island)" /protein_id="NP_388935.2" /db_xref="EnsemblGenomes-Gn:BSU10540" /db_xref="EnsemblGenomes-Tr:CAB12894" /db_xref="GOA:O07565" /db_xref="InterPro:IPR006379" /db_xref="InterPro:IPR006380" /db_xref="InterPro:IPR036412" /db_xref="PDB:3GYG" /db_xref="SubtiList:BG13077" /db_xref="UniProtKB/Swiss-Prot:O07565" /translation="MLLSKKSEYKTLSTVEHPQYIVFCDFDETYFPHTIDEQKQQDIY ELEDYLEQKSKDGELIIGWVTGSSIESILDKMGRGKFRYFPHFIASDLGTEITYFSEH NFGQQDNKWNSRINEGFSKEKVEKLVKQLHENHNILLNPQTQLGKSRYKHNFYYQEQD EINDKKNLLAIEKICEEYGVSVNINRCNPLAGDPEDSYDVDFIPIGTGKNEIVTFMLE KYNLNTERAIAFGDSGNDVRMLQTVGNGYLLKNATQEAKNLHNLITDSEYSKGITNTL KKLIGS*" /label="ntdB CDS" gene complement(1077043..1077891) /gene="ntdB" /locus_tag="BSU_10540" /old_locus_tag="BSU10540" /label="ntdB gene" CDS complement(1077863..1079188) /gene="ntdA" /locus_tag="BSU_10550" /old_locus_tag="BSU10550" /EC_number="2.6.1.-" /function="16.5: Explore" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:14612444, 17056753, 19087206, 23586652, 24097983, 24509311, 28353336" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14612444, 17056753, 19087206, 23586652, 24097983, 24509311, 28353336; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="biosynthesis of neotrehalosadiamine (3,3'-diamino-3,3'-dideoxy-alpha, beta-trehalose);3-oxo-glucose-6-phosphate:glutamate aminotransferase; kanosamine aminotransferase (recent HGT island)" /protein_id="NP_388936.1" /db_xref="EnsemblGenomes-Gn:BSU10550" /db_xref="EnsemblGenomes-Tr:CAB12895" /db_xref="GOA:O07566" /db_xref="InterPro:IPR000653" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="PDB:4K2B" /db_xref="PDB:4K2I" /db_xref="PDB:4K2M" /db_xref="SubtiList:BG13078" /db_xref="UniProtKB/Swiss-Prot:O07566" /translation="MQKQVKISGKSKENMSLLKHLKGDVQGKELVIEDSIVNERWKQV LKEKIDIEHDLFNYQKNREISKVPFLPVDRLITNDEVEDILNTLTEVLPTGKFTSGPY LEQFEKVLSTYLHKRYVIATSSGTDAIMIGLLALGLNPGDEVIMPANSFSATENAVLA SGGVPIYVDINPQTFCIDPDKIEEAITPYTKFILPVHLYGKHSDMQHIRQIANRYKLK VIEDACQGIGLTDLGKYADITTLSFNPYKNFGVCGKAGAIATDNEELAKKCIQFSYHG FEVNVKNKKVINFGFNSKMDNLQAAIGLERMKYLSLNNFKRLFLADRYITQLAELQNK GYIELPELSEDHVWHLFPIKVRTEDRADIMTKLNEDFGVQTDVYYPILSHMQKTPLVQ DKYAGLQLVHTEKAHSQVLHLPLYPSFTLEEQDRVMEGLFHVIKQEIGV*" /label="ntdA CDS" gene complement(1077863..1079188) /gene="ntdA" /locus_tag="BSU_10550" /old_locus_tag="BSU10550" /label="ntdA gene" promotor_-35 1078032..1078037 /Source="Nicolas_upshift_promotors" /id="U853" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1031 /SigmaFactorBS="cctgcatacttgtcctgtactaaaggagtttttTGCATAtga gaaagtattggaTAATATACATCTGTTTGAAcaccaaaatcttcatttaatttagtca t" /listShort="S373, S374, yhjM" /listLong="S375" /label="promotor_-35" promotor_-10 1078053..1078071 /Source="Nicolas_upshift_promotors" /id="U853" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1031 /SigmaFactorBS="cctgcatacttgtcctgtactaaaggagtttttTGCATAtga gaaagtattggaTAATATACATCTGTTTGAAcaccaaaatcttcatttaatttagtca t" /listShort="S373, S374, yhjM" /listLong="S375" /label="promotor_-10" S_feature 1078059..1078847 /Source="Nicolas_S_feature" /locus_tag="new_1128482_1129270" /HighExp="S4, S3, S5, S6, S7, T5.0H, M9-stat, S8, Pyr, G/S" /AntisenseName="ntdA" /AntisenseCor="-0.29559566742128002" /AntisenseRegPval="-6.1" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S373" upshifts 1078059 /Source="Nicolas_upshifts" /id="U853" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1031 /SigmaFactorBS="cctgcatacttgtcctgtactaaaggagtttttTGCATAtga gaaagtattggaTAATATACATCTGTTTGAAcaccaaaatcttcatttaatttagtca t" /listShort="S373, S374, yhjM" /listLong="S375" /label="upshifts" promotor_-35 1078823..1078830 /Source="Nicolas_upshift_promotors" /id="U854" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.776223776223776" /psig="0.998001998001998" /xcortree=2928 /SigmaFactorBS="ataaacctatcataatagcatcggttccactgctGGTTGCAA ttacataccttttaTGTAAATATGTAGATAAAACtttttcgaattgctctaaataggg a" /listShort="S374, yhjM, S375" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1078845..1078864 /Source="Nicolas_upshift_promotors" /id="U854" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.776223776223776" /psig="0.998001998001998" /xcortree=2928 /SigmaFactorBS="ataaacctatcataatagcatcggttccactgctGGTTGCAA ttacataccttttaTGTAAATATGTAGATAAAACtttttcgaattgctctaaataggg a" /listShort="S374, yhjM, S375" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1078849..1079291 /Source="Nicolas_S_feature" /locus_tag="new_1129272_1129714" /HighExp="T4.0H, T3.0H, T2.30H, HiOs, T3.30H, T2.0H, T5.0H, T1.30H, LoTm, T-1.10H" /AntisenseName="ntdA" /AntisenseCor="-0.101471720232752" /AntisenseRegPval="-1" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="0.998, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S374" upshifts 1078849 /Source="Nicolas_upshifts" /id="U854" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.776223776223776" /psig="0.998001998001998" /xcortree=2928 /SigmaFactorBS="ataaacctatcataatagcatcggttccactgctGGTTGCAA ttacataccttttaTGTAAATATGTAGATAAAACtttttcgaattgctctaaataggg a" /listShort="S374, yhjM, S375" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1079223..1079242) /Source="Nicolas_upshift_promotors" /id="U855" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.849150849150849" /psig="0.97902097902098" /xcortree=1578 /SigmaFactorBS="gcatattttcccttccttaaaaaagttgttgaCATGTTACcg atttcagaaacTAGGATAAATTTGTAATAAAtttttagattataaaatcattggaggt a" /listShort="ntdA, ntdB, ntdC, glcP, S371" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1079235) /Source="Nicolas_upshifts" /id="U855" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.849150849150849" /psig="0.97902097902098" /xcortree=1578 /SigmaFactorBS="gcatattttcccttccttaaaaaagttgttgaCATGTTACcg atttcagaaacTAGGATAAATTTGTAATAAAtttttagattataaaatcattggaggt a" /listShort="ntdA, ntdB, ntdC, glcP, S371" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1079256..1079263) /Source="Nicolas_upshift_promotors" /id="U855" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.849150849150849" /psig="0.97902097902098" /xcortree=1578 /SigmaFactorBS="gcatattttcccttccttaaaaaagttgttgaCATGTTACcg atttcagaaacTAGGATAAATTTGTAATAAAtttttagattataaaatcattggaggt a" /listShort="ntdA, ntdB, ntdC, glcP, S371" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1079292..1080281 /gene="ntdR" /locus_tag="BSU_10560" /old_locus_tag="BSU10560" /experiment="publication(s) with functional evidences, PMID:14612444, 17056753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14612444, 17056753; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of the ntd operon (NtdR-NTD) (recent HGT island)" /protein_id="NP_388937.1" /db_xref="EnsemblGenomes-Gn:BSU10560" /db_xref="EnsemblGenomes-Tr:CAB12896" /db_xref="GOA:O07567" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG13079" /db_xref="UniProtKB/Swiss-Prot:O07567" /translation="MPTIDEIAKLCNVSKTTVSRVLNNHPYVSKEKRDMILKAINELD YTPNYLARNFRRNKTQTIALSVPSIDHPFFAQLIKGVSHEVLFKNYKVIVFQTFYDKQ TELELLELLKHKEVDGIILGTLENEWDQISPFLKYGPILLCNEYHHSADITIIGYDEF EAAYMGVVHLIERGHKKIGFCFDTPYSEAQCQRKEGYLKALQDYNLHHRSEWIFGEMF NIEDGFRVFHKIKDLKDRPSAIFTGNDQVAAGIIKQAMKNGFKVPEDLAVIGFDNQLI CQVVTPTITTIDIPVIELGQQAVLKIIESISGNASLNRRIIKLPTKLIIREST*" /label="ntdR CDS" gene 1079292..1080281 /gene="ntdR" /locus_tag="BSU_10560" /old_locus_tag="BSU10560" /label="ntdR gene" S_feature 1080282..1080659 /Source="Nicolas_S_feature" /locus_tag="new_1130705_1131082" /HighExp="T4.0H, T5.0H, T3.30H, T2.0H, HiOs, T2.30H, T3.0H, LoTm, T1.30H, Pyr" /AntisenseName="yhjN" /AntisenseCor="-5.0383887616073E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="SigEF" /TUlongPSig="0.997" /label="S375" S_feature complement(1080336..1080494) /Source="Nicolas_S_feature" /locus_tag="new_1130759_1130917_c" /HighExp="B60, Sw, Cold, B36, BI, GM 15, GM 10, C30, GM 25, GM 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S376" downshifts complement(1080379) /Source="Nicolas_upshifts" /id="D577" /incds=0 /nref=25 /ntot=169 /MaxReadThrough="3.07371" /MaxDrop="4.24831" /score="-1.9470655" /energy="-7.1" /TU="U856" /idTUdmin="U856" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" CDS complement(1080495..1081649) /gene="yhjN" /locus_tag="BSU_10570" /old_locus_tag="BSU10570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein (recentHGT island)" /protein_id="NP_388938.1" /db_xref="EnsemblGenomes-Gn:BSU10570" /db_xref="EnsemblGenomes-Tr:CAB12897" /db_xref="GOA:O07568" /db_xref="InterPro:IPR007820" /db_xref="InterPro:IPR017516" /db_xref="SubtiList:BG13080" /db_xref="UniProtKB/Swiss-Prot:O07568" /translation="MKKDENLLKDLWFIAISAAGGFILSLTGISIGWMIGTLIVACCL AMIRPAWLMMAPDQKGINRRWLALGQMILGIELGQKLNLSVLSVLKDHWFSVGVMLIL SILLAMLSGYVLWRFSKTDMMTSFVGTAPGGLSAMPSIAQEVGANTAIVSLVQMMRVL LVVLSIPFLVILIYTKQDRTASAAAETISSATTDFRLAPVLWTVILILAAWGACKAAK FLKFPAPWLLGSMLGVAIVHVGGAAVTGHDMTAWWLSQANHVSQVFLGATIGSKMYKS MFAGVTRIIIVGFVSSVGLIAAMFLSAVIVSELTGISLITSVLAFAPGGIAEMATTSV TLHADSTFVVAVQVIRVILVIALLPPFYRLLHHLHGEKKDKKSSISGSSA*" /label="yhjN CDS" gene complement(1080495..1081649) /gene="yhjN" /locus_tag="BSU_10570" /old_locus_tag="BSU10570" /label="yhjN gene" S_feature complement(1081650..1081721) /Source="Nicolas_S_feature" /locus_tag="new_1132073_1132144_c" /HighExp="Cold, GM 15, GM 10, dia15, BC, BI, Salt, B60, Sw, GM 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S377" promotor_-10 complement(1081704..1081723) /Source="Nicolas_upshift_promotors" /id="U856" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.414585414585415" /psig="0.99000999000999" /xcortree=2773 /SigmaFactorBS="cataagaaaagtgaatcgcttatagaaaataattcataATTT CTttatcaacaaaaaTATACTATAGTAATAAATACattcactacgtgaacaattggag t" /listShort="S377, yhjN, S376" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1081720) /Source="Nicolas_upshifts" /id="U856" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.414585414585415" /psig="0.99000999000999" /xcortree=2773 /SigmaFactorBS="cataagaaaagtgaatcgcttatagaaaataattcataATTT CTttatcaacaaaaaTATACTATAGTAATAAATACattcactacgtgaacaattggag t" /listShort="S377, yhjN, S376" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1081737..1081742) /Source="Nicolas_upshift_promotors" /id="U856" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.414585414585415" /psig="0.99000999000999" /xcortree=2773 /SigmaFactorBS="cataagaaaagtgaatcgcttatagaaaataattcataATTT CTttatcaacaaaaaTATACTATAGTAATAAATACattcactacgtgaacaattggag t" /listShort="S377, yhjN, S376" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1081756..1082961) /gene="yhjO" /locus_tag="BSU_10580" /old_locus_tag="BSU10580" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease (recent HGT island)" /protein_id="NP_388939.1" /db_xref="EnsemblGenomes-Gn:BSU10580" /db_xref="EnsemblGenomes-Tr:CAB12898" /db_xref="GOA:O07569" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13081" /db_xref="UniProtKB/Swiss-Prot:O07569" /translation="MLTSFHSIKSRYTAPVRLRFFGELLTSLTGAMMGPFMVLYLHEQ LNGSIMMPMLIISLQPFADIFLTLAAGRVTDRLGRRTAILTALLLQSAAMTGFVFAEH AYVFAILYVMNGIGRSLYIPASRAQIAESTPESRRSEVFAVINAIYSTGLTAGPLVGM LLYNHNPVWIFALDAAALFIYFLIAALKLPETKPLHPAVTPKMSASFTIYRPVLLLLL LSLPISMLYAQTETTYRLFSKNMFSDYLSMLTIYSAAKALFSCVLQVPLVKGTEKLSM KTILFITYICYSLAAAGFACSTSLTMLLVTAAVMTVGESIGLTHIQTFISKLAPPHLL GRFYAVYGLHWDISRSIGPLAGGLILTSFGGEVIFYALAVCLLTAGLSLTYTIEKLEH KVIRKVNRL*" /label="yhjO CDS" gene complement(1081756..1082961) /gene="yhjO" /locus_tag="BSU_10580" /old_locus_tag="BSU10580" /label="yhjO gene" misc_feature 1082982..1083001 /Source="Nicolas_upshift_promotors" /id="U857" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.699300699300699" /psig="0.999000999001" /xcortree=2118 /SigmaFactorBS="tatctcgattttatagagtgaaaactggtcaacatgtgatcg ccgcctttcgctgTTTGATATAGTAGTAGTGTAtagaaggggcggcggcccaaaaagt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1082987 /Source="Nicolas_upshifts" /id="U857" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.699300699300699" /psig="0.999000999001" /xcortree=2118 /SigmaFactorBS="tatctcgattttatagagtgaaaactggtcaacatgtgatcg ccgcctttcgctgTTTGATATAGTAGTAGTGTAtagaaggggcggcggcccaaaaagt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1083075..1084802 /gene="yhjP" /locus_tag="BSU_10590" /old_locus_tag="BSU10590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcription factor" /protein_id="NP_388940.1" /db_xref="EnsemblGenomes-Gn:BSU10590" /db_xref="EnsemblGenomes-Tr:CAB12899" /db_xref="GOA:O07570" /db_xref="InterPro:IPR000914" /db_xref="InterPro:IPR025370" /db_xref="InterPro:IPR030678" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG13082" /db_xref="UniProtKB/Swiss-Prot:O07570" /translation="MKLIEHYVALVKTGCAEYGQMNEMTLTEIADCLFCTERNAKLIL HKLENSNWIIRESGAGRGRKSKIAFLRRPEELLLQTAKEYTMSGKLKKAKELLQQYQS AFPGLQNEYNMWLSEVFGFVTETGENGAKDVLRLFITPESVSSLDPCQIFLRSEGHFV KQIFDTLFTFDSDMQEPKPHLVHGWEEVGKKQWRFFLRKGVLFHNGQPLTSRDVAFTF QRFLELADNPYKWLLHGVKQVLEKGPYCVELILDKPNALLPYALCDERLSILPAEQGG GKNGTGPFQMNQQHSGMLVLEANERYFKGRPYLDRVEFVFSEQAGEMNGFTIQEKQTC PEQQTVFDERHVQYLSLNLKKKGPLQHRSFRKALRLLISSERLVREAGGHRRIPVTSF LHPSPFEWEGVSPSELLKKSGYEGETIVLYTFSETDHREDAEWIQNICAQHGIRLTLQ FCDAADLRRPEIVQMADIIHDSATFYQDSEFGFLHLLLSENSFLYQHLSEKLTQICSG MTERMFSMPDRCSRINILRDIDRQMIQELNAIPLYQNVLQVTSSKNVKGLVLDEEGWI DLYSVWLSK*" /label="yhjP CDS" gene 1083075..1084802 /gene="yhjP" /locus_tag="BSU_10590" /old_locus_tag="BSU10590" /label="yhjP gene" promotor_-35 1084388..1084395 /Source="Nicolas_upshift_promotors" /id="U858" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.531468531468531" /psig="0.802197802197802" /xcortree=1827 /SigmaFactorBS="atcatcgtgaggacgccgaatggattcaaaaTATTTGCGccc agcacggtatcAGGCTTACACTTCAATTCTGtgatgctgctgatctgcgacggccgga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1084410..1084429 /Source="Nicolas_upshift_promotors" /id="U858" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.531468531468531" /psig="0.802197802197802" /xcortree=1827 /SigmaFactorBS="atcatcgtgaggacgccgaatggattcaaaaTATTTGCGccc agcacggtatcAGGCTTACACTTCAATTCTGtgatgctgctgatctgcgacggccgga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1084417 /Source="Nicolas_upshifts" /id="U858" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.531468531468531" /psig="0.802197802197802" /xcortree=1827 /SigmaFactorBS="atcatcgtgaggacgccgaatggattcaaaaTATTTGCGccc agcacggtatcAGGCTTACACTTCAATTCTGtgatgctgctgatctgcgacggccgga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1084832..1085158) /gene="yhjQ" /locus_tag="BSU_10600" /old_locus_tag="BSU10600" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12625841; Product type c: carrier" /codon_start=1 /transl_table=11 /product="putative metal-chelating cysteine-rich protein of unknown function" /protein_id="NP_388941.1" /db_xref="EnsemblGenomes-Gn:BSU10600" /db_xref="EnsemblGenomes-Tr:CAB12900" /db_xref="InterPro:IPR005560" /db_xref="PDB:5FIG" /db_xref="SubtiList:BG13083" /db_xref="UniProtKB/Swiss-Prot:O07571" /translation="MEQYSEACIEACIDCMKACNHCFTKCLEESVQHHLSGCIRLDRE CADICALAVKAMQTDSPFMKEICALCADICEACGTECGKHDHDHCQACAKACFTCAEQ CRSMAA*" /label="yhjQ CDS" gene complement(1084832..1085158) /gene="yhjQ" /locus_tag="BSU_10600" /old_locus_tag="BSU10600" /label="yhjQ gene" CDS complement(1085276..1085713) /gene="yhjR" /locus_tag="BSU_10610" /old_locus_tag="BSU10610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22078549, 22882546; Product type c: carrier" /codon_start=1 /transl_table=11 /product="putative electron carrier protein (putative sporulation gene)" /protein_id="NP_388942.1" /db_xref="EnsemblGenomes-Gn:BSU10610" /db_xref="EnsemblGenomes-Tr:CAB12901" /db_xref="GOA:O07572" /db_xref="InterPro:IPR003251" /db_xref="InterPro:IPR009078" /db_xref="InterPro:IPR012347" /db_xref="SubtiList:BG13084" /db_xref="UniProtKB/Swiss-Prot:O07572" /translation="MHYSYYPYPVPYREDPVLIRNLQKAINGEFSAIQCYRKLAELAH SDEVRKQIEEIRRDEIRHLREFSTLYGSITGKHIMPKQTEECPDNFTRGLDAAFKDEQ ETVDFYLRAAEETSNLKAKGVFTRAARDEQNHAVWFLYYLMER*" /label="yhjR CDS" gene complement(1085276..1085713) /gene="yhjR" /locus_tag="BSU_10610" /old_locus_tag="BSU10610" /label="yhjR gene" downshifts complement(1085285) /Source="Nicolas_upshifts" /id="D578" /incds=0 /nref=1 /ntot=10 /MaxReadThrough="3.72767" /MaxDrop="3.86885" /score="16.2430017" /energy="-11.5" /TU="U859" /idTUdmin="U859" /TUdmin="-440" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1085744..1085763) /Source="Nicolas_upshift_promotors" /id="U859" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1267 /SigmaFactorBS="tggtaaaaacggccttttcacatataaaaagctgattatCTC CGCACATctctccctgcccAACATATACTTTTACAGAAGcccaattcctaagaatgga g" /listShort="yhjR, yhjQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1085764) /Source="Nicolas_upshifts" /id="U859" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1267 /SigmaFactorBS="tggtaaaaacggccttttcacatataaaaagctgattatCTC CGCACATctctccctgcccAACATATACTTTTACAGAAGcccaattcctaagaatgga g" /listShort="yhjR, yhjQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1085776..1085785) /Source="Nicolas_upshift_promotors" /id="U859" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1267 /SigmaFactorBS="tggtaaaaacggccttttcacatataaaaagctgattatCTC CGCACATctctccctgcccAACATATACTTTTACAGAAGcccaattcctaagaatgga g" /listShort="yhjR, yhjQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1085833..1085840 /Source="Nicolas_upshift_promotors" /id="U860" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.875124875124875" /psig=1 /xcortree=1809 /SigmaFactorBS="gaaaaggccgtttttaccaatagatcaGATTGGTCattttcg tcaacaTTCGATAAAATATAGAGAGAtaaaaagagaggggtcttctaatttgggagca g" /listShort="addB, addA, S378, sbcD, sbcC, yisB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1085854..1085873 /Source="Nicolas_upshift_promotors" /id="U860" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.875124875124875" /psig=1 /xcortree=1809 /SigmaFactorBS="gaaaaggccgtttttaccaatagatcaGATTGGTCattttcg tcaacaTTCGATAAAATATAGAGAGAtaaaaagagaggggtcttctaatttgggagca g" /listShort="addB, addA, S378, sbcD, sbcC, yisB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1085866 /Source="Nicolas_upshifts" /id="U860" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.875124875124875" /psig=1 /xcortree=1809 /SigmaFactorBS="gaaaaggccgtttttaccaatagatcaGATTGGTCattttcg tcaacaTTCGATAAAATATAGAGAGAtaaaaagagaggggtcttctaatttgggagca g" /listShort="addB, addA, S378, sbcD, sbcC, yisB" /GFF_Attribute="listLong" /label="upshifts" CDS 1085897..1089397 /gene="addB" /locus_tag="BSU_10620" /old_locus_tag="BSU10620" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:7746142, 8387145, 8510642, 8752323, 11544244, 16385024, 16780573, 19542287, 21071401, 22307084, 24670664, 26762979" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7746142, 8387145, 8510642, 8752323, 11544244, 16385024, 16780573, 19542287, 21071401, 22307084, 24670664, 26762979; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent deoxyribonuclease (subunit B)" /protein_id="NP_388943.2" /db_xref="EnsemblGenomes-Gn:BSU10620" /db_xref="EnsemblGenomes-Tr:CAB12902" /db_xref="GOA:P23477" /db_xref="InterPro:IPR014016" /db_xref="InterPro:IPR014017" /db_xref="InterPro:IPR014140" /db_xref="InterPro:IPR027417" /db_xref="PDB:3U44" /db_xref="PDB:3U4Q" /db_xref="PDB:4CEH" /db_xref="PDB:4CEI" /db_xref="PDB:4CEJ" /db_xref="SubtiList:BG10465" /db_xref="UniProtKB/Swiss-Prot:P23477" /translation="MGAEFLVGRSGSGKTKLIINSIQDELRRAPFGKPIIFLVPDQMT FLMEYELAKTPDMGGMIRAQVFSFSRLAWRVLQHTGGMSRPFLTSTGVQMLLRKLIEE HKQEFKVYQKASDKSGFTAQVERMLTEFKRYCLEPEDIRRMAESGTASEYRGERVLSE KLHDLSILYQQMEKSLADQYLHSEDYLTLLAEHIPLAEDIKGAHIYVDGFYQFTPQEF RVLEQLMVHAEHITFSLTADKPSYEREPHELELFRMTGKTYYRLHQKAKELNLDITYK ELSGTERHTKTPELAHLEAQYEARPAIPYAEKQEALTVMQAANRRAELEGIAREIHAL VREKGYRYKDVAILARQPEDYKDMVKEVFADYEIPYFIDGKASMLNHPLIEFIRSSLD VLKGNWRYEAVFRCVKTELLFPLNEPKAKVREQVDQLENYCIAYGIKGDRWTKGDRFQ YRRFVSLDDDFAQTDQEIEMENMLNDTRDWIVPPLFQLQKRMKKAKTVQEKAEALYRY LEETDVPLKLDQERQRAEDDGRIIEAQQHQQAWDAVIQLLEEFVEMMGDDEISLDLFQ QMIEAGAESLTFSLIPPALDQVFVGNMDLSRMYGTSCTFVLGANDGVLPARPDENGVL SDDDREWLKTIGVELSSGGRERLLDEHFLIYMAFSSPSDRLYVSYPIADAEGKTLLPS MIVKRLEELFPHHKERLLTNEPEQVSDEEQLMYVVNKSVAQSFTASQLRLWTREYDIS DVWWSTYNVLMSEQDRLQSKKLFSSLFFRNEVKQLERSVSRQLYGERIQGSVSRMETF NACPFSHFASHGLHLKERQFFKLEAPDIGQLFHSSLKLISDRLREQKLDWRDLTKEQC ELFSYDAVERLAPKLQKEILLSSNRHYYVKEKLQKIVTRVSGILSEHAKASGFVPIGL ELGFGGKGPLPPLTFQLKNGCTMELVGRIDRVDKAESSKGLLLRIVDYKSSDKGLDLA EVYYGLALQMLTYLDLSITHSADWLGMRATPAGVLYFHIHDPMIQSNLPLGLDEIEQE IFKKFKMKGLLLGDQEVVRLMDTTLQEGRSNIINAGLKKDGSLRSDSAAVGEKEFDLL TKHVRRTFQEAGEQITDGRVSIEPYKMKNKTPCTYCAFKSVCQFDESLEENEYRPLKA EKDKTILEWIKKEADGNEHS*" /label="addB CDS" gene 1085897..1089397 /gene="addB" /locus_tag="BSU_10620" /old_locus_tag="BSU10620" /label="addB gene" CDS 1089384..1093082 /gene="addA" /locus_tag="BSU_10630" /old_locus_tag="BSU10630" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:7746142, 8387145, 8510642, 8752323, 11544244, 16385024, 16780573, 19542287, 21071401, 22307084, 24670664, 26762979" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7746142, 8387145, 8510642, 8752323, 11544244, 16385024, 16780573, 19542287, 21071401, 22307084, 24670664, 26762979; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent deoxyribonuclease (subunit A)" /protein_id="NP_388944.2" /db_xref="EnsemblGenomes-Gn:BSU10630" /db_xref="EnsemblGenomes-Tr:CAB12903" /db_xref="GOA:P23478" /db_xref="InterPro:IPR000212" /db_xref="InterPro:IPR011335" /db_xref="InterPro:IPR011604" /db_xref="InterPro:IPR014016" /db_xref="InterPro:IPR014017" /db_xref="InterPro:IPR014152" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR034739" /db_xref="PDB:3U44" /db_xref="PDB:3U4Q" /db_xref="PDB:4CEH" /db_xref="PDB:4CEI" /db_xref="PDB:4CEJ" /db_xref="SubtiList:BG10466" /db_xref="UniProtKB/Swiss-Prot:P23478" /translation="MNIPKPADSTWTDDQWNAIVSTGQDILVAAAAGSGKTAVLVERM IRKITAEENPIDVDRLLVVTFTNASAAEMKHRIAEALEKELVQRPGSLHIRRQLSLLN RASISTLHSFCLQVLKKYYYLIDLDPGFRIADQTEGELIGDEVLDELFEDEYAKGEKA FFELVDRYTTDRHDLDLQFLVKQVYEYSRSHPNPEAWLESFVHLYDVSEKSAIEELPF YQYVKEDIAMVLNGAKEKLLRALELTKAPGGPAPRADNFLDDLAQIDELIQHQDDFSE LYKRVPAVSFKRAKAVKGDEFDPALLDEATDLRNGAKKLLEKLKTDYFTRSPEQHLKS LAEMKPVIETLVQLVISYGKRFEAAKQEKSIIDFSDLEHYCLAILTAENDKGEREPSE AARFYQEQFHEVLVDEYQDTNLVQESILQLVTSGPEETGNLFMVGDVKQSIYRFRLAE PLLFLSKYKRFTESGEGTGRKIDLNKNFRSRADILDSTNFLFKQLMGGKIGEVDYDEQ AELKLGAAYPDNDETETELLLIDNAEDTDASEEAEELETVQFEAKAIAKEIRKLISSP FKVYDGKKKTHRNIQYRDIVILLRSMPWAPQIMEELRAQGIPVYANLTSGYFEAVEVA VALSVLKVIDNPYQDIPLASVLRSPIVGADENELSLIRLENKKAPYYEAMKDYLAAGD RSDELYQKLNTFYGHLQKWRAFSKNHSVSELIWEVYRDTKYMDYVGGMPGGKQRQANL RVLYDRARQYESTAFRGLFRFLRFIERMQERGDDLGTARALSEQEDVVRLMTIHSSKG LEFPVVFVAGLGRNFNMMDLNKSYLLDKELGFGTKYIHPQLRISYPTLPLIAMKKKMR RELLSEELRVLYVALTRAKEKLFLIGSCKDHQKQLAKWQASASQTDWLLPEFDRYQAR TYLDFIGPALARHRDLGDLAGVPAHADISGHPARFAVQMIHSYDLLDDDLEERMEEKS ERLEAIRRGEPVPGSFAFDEKAREQLSWTYPHQEVTQIRTKQSVSEIKRKREYEDEYS GRAPVKPADGSILYRRPAFMMKKGLTAAEKGTAMHTVMQHIPLSHVPSIEEAEQTVHR LYEKELLTEEQKDAIDIEEIVQFFHTEIGGQLIGAKWKDREIPFSLALPAKEIYPDAH EADEPLLVQGIIDCLYETEDGLYLLDYKSDRIEGKFQHGFEGAAPILKKRYETQIQLY TKAVEQIAKTKVKGCALYFFDGGHILTL*" /label="addA CDS" gene 1089384..1093082 /gene="addA" /locus_tag="BSU_10630" /old_locus_tag="BSU10630" /label="addA gene" S_feature 1093083..1093153 /Source="Nicolas_S_feature" /locus_tag="new_1143506_1143576" /HighExp="H2O2, C90, Heat, LBGtran, dia15, HiTm, Diami, C30, Lbtran, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S378" CDS 1093154..1094329 /gene="sbcD" /locus_tag="BSU_10640" /old_locus_tag="BSU10640" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:7968921, 8493111, 16780573" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7968921, 8493111, 16780573; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA repair exonuclease" /protein_id="NP_388945.3" /db_xref="EnsemblGenomes-Gn:BSU10640" /db_xref="EnsemblGenomes-Tr:CAB12904" /db_xref="GOA:P23479" /db_xref="InterPro:IPR004593" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR026843" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG10467" /db_xref="UniProtKB/Swiss-Prot:P23479" /translation="MRILHTADWHLGKTLEGRSRLSEQADVLDELNTIVKDEQIDAIV MAGDAFDTVNPPALAEQLFYESLSALSDRGKRPIVVIAGNHDNPDRLSAASPLTHENG IHLIGYPTTEPIHIEVPSAGELLAVGALAYPSEARLNEVLSDTFDEKLLRDHYDVKIR QAFEHMTSRFRTDAVKIAASHIYVAGGNQTDSERPIEVGGAYTVAAESLPADAAYVAL GHLHRPQTIKRARTLARYSGSPLAYSFSEAGYAKSVTIVDAKPGEEATWQEVLLSSGK PLVKWKAANGLSEVYSWLDEGRDQNAWIDLEIRVADQLSLEEIHRLRKAHPGFIHIRP VFEEQNKDRERIEVKHVSIEDRFKKFYEKQTGGAVPDEEMVKLFLELASGVEEEDAK* " /label="sbcD CDS" gene 1093154..1094329 /gene="sbcD" /locus_tag="BSU_10640" /old_locus_tag="BSU10640" /label="sbcD gene" CDS 1094326..1097718 /gene="sbcC" /locus_tag="BSU_10650" /old_locus_tag="BSU10650" /function="16.9: Replicate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16780573, 19906728" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16780573, 19906728; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA ATP-dependent repair enzyme" /protein_id="NP_388946.2" /db_xref="EnsemblGenomes-Gn:BSU10650" /db_xref="EnsemblGenomes-Tr:CAB12905" /db_xref="GOA:O06714" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13088" /db_xref="UniProtKB/Swiss-Prot:O06714" /translation="MKPIALSIKGLHSFREEQTIDFEGLSGAGVFGIFGPTGSGKSSI LDAMTLALYGKVERAANNTHGILNHAEDTLSVSFTFALQTNHQISYKVERVFKRTDEM KVKTALCRFIEIKDEHTVLADKASEVNKRVEELLGLTIDDFTRAVVLPQGKFAEFLSL KGAERRHMLQRLFNLEQYGDRLVKKLRRQAQEANARKNEMLAEQSGLGEASSEAVEQA EKVLEQAEARLEAMRKNRDQAKERFTEHQEIWNVQKEKSTYEEEEKRLAEEQPHIDSM QKRLLEAETAAALKPYADRYAEAIQHEEQAEKEQTLAQKDLADRTAFFQQKHEEYEAW RQHKSEKEPELLAKQEQLSRLQEIEIKLSEAKQEEERKKADLRQKEEALQSVMNELET VTDRLTRGQNRQTELKQQLKSLQVTSDERKSCQQAAEMALRIRQTEEQIKKEKKRSEE LNLVLQKMNEEKNTLVQKTEAEENNIIQAYEAVQTVYHLVCETERSLTRMTEEARKSQ HTLHLQREKARVALLTKELAQKLTAGKPCPVCGSTDHDPSASVHETYEADSHLEEDIK RTDVLLTEAAALSQEILSAKIMLEEQSARFIEQCPFLQTIQAQNLEAAASFEHQPVYE AFETAKFEWKRIKQDILSVKTRMAQMIGAYQESLKKAEQLNEKIGFEKREADRIESII SELQSSMDSSLNMFKEAFQNQSVDEAEKWQQAIEEKDRAAEECEKRIEKSIAFLAEHE AQKEKLRESGHRLEREKLELHYAAERIKSVIADYEHELGDYAKGDSIQIKLRSVQQDL KLLKEKEQSLYEELQSAQMKLNQAKSRASASELTLQEAKGRLEKAKAAWLEHTKNTSI TRTEEVEQSLIPADELEKMKTGIDQFMDKLKQNAANLKRVAEILAGRALSESEWNETV AALQEAEDAFGAAIEEKGAAAKALAVIRDHHKRFNEIEAELKKWQMHIDRLDKLQAVF KGNTFVEFLAEEQLESVARDASARLSMLTRQRYAIEVDSEGGFVMRDDANGGVRRPVS SLSGGETFLTSLSLALALSAQIQLRGEYPLQFFFLDEGFGTLDQDLLDTVVTALEKLQ SDNLAVGVISHVQELRARLPKKLIVHPAEPSGRGTRVSLELM*" /label="sbcC CDS" gene 1094326..1097718 /gene="sbcC" /locus_tag="BSU_10650" /old_locus_tag="BSU10650" /label="sbcC gene" promotor_-35 1096973..1096979 /Source="Nicolas_upshift_promotors" /id="U861" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=813 /SigmaFactorBS="tgaaaagatgaaaaccggcatagaccagtttaTGGATAAact gaagcaaaatgCTGCAAACTTAAaacgagtagcagagatacttgccggcagagcatta t" /listShort="yisB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1096994..1097005 /Source="Nicolas_upshift_promotors" /id="U861" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=813 /SigmaFactorBS="tgaaaagatgaaaaccggcatagaccagtttaTGGATAAact gaagcaaaatgCTGCAAACTTAAaacgagtagcagagatacttgccggcagagcatta t" /listShort="yisB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1097001 /Source="Nicolas_upshifts" /id="U861" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=813 /SigmaFactorBS="tgaaaagatgaaaaccggcatagaccagtttaTGGATAAact gaagcaaaatgCTGCAAACTTAAaacgagtagcagagatacttgccggcagagcatta t" /listShort="yisB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1097070..1098043) /Source="Nicolas_S_feature" /locus_tag="new_1147493_1148466_c" /HighExp="S6, S8, S7, BT, C30, B36, S5, C90, Pyr, B60" /AntisenseName="yisB" /AntisenseCor="0.19649597897587401" /AntisenseRegPval="-2.9" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="SigK" /TUlongPSig="0.992" /label="S379" CDS 1097732..1098034 /gene="hlpB" /locus_tag="BSU_10660" /old_locus_tag="BSU10660" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16780573, 22984257" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16780573, 22984257; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="HNH nuclease-like essential for DNA repair" /protein_id="NP_388947.1" /db_xref="EnsemblGenomes-Gn:BSU10660" /db_xref="EnsemblGenomes-Tr:CAB12906" /db_xref="SubtiList:BG13089" /db_xref="UniProtKB/Swiss-Prot:O06715" /translation="MAKQIAGICELCGRSDVQLTEHHLTPKEEGGTFLPTAMLCIPCH KQIHALYTNQELAVRLNGMAELRSDPELARFVKWIRKQPPEKLIKTKKSNERKKKK*" /label="hlpB CDS" gene 1097732..1098034 /gene="hlpB" /locus_tag="BSU_10660" /old_locus_tag="BSU10660" /label="hlpB gene" downshifts 1098014 /Source="Nicolas_upshifts" /id="D579" /incds=0 /nref=230 /ntot=269 /MaxReadThrough="1.42126" /MaxDrop="6.71114" /score="0.317490594" /energy="-14.3" /TU="NA" /idTUdmin="U861" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(1098071..1098289) /gene="gerPF" /locus_tag="BSU_10670" /old_locus_tag="BSU10670" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10715007, 20161744" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10715007, 20161744; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination protein" /protein_id="NP_388948.2" /db_xref="EnsemblGenomes-Gn:BSU10670" /db_xref="EnsemblGenomes-Tr:CAB12907" /db_xref="GOA:O06716" /db_xref="InterPro:IPR019618" /db_xref="SubtiList:BG13090" /db_xref="UniProtKB/Swiss-Prot:O06716" /translation="MPAIVGPIAINSISGGVVNFGDSFYLSPKSSSKSALGSGAGNTG DFLLLNNAVNATNYIDPDVNDQDMVGNG*" /label="gerPF CDS" gene complement(1098071..1098289) /gene="gerPF" /locus_tag="BSU_10670" /old_locus_tag="BSU10670" /label="gerPF gene" downshifts complement(1098088) /Source="Nicolas_upshifts" /id="D580" /incds=0 /nref=40 /ntot=66 /MaxReadThrough="3.93344" /MaxDrop="5.39228" /score="13.5435041" /energy="-15.3" /TU="U863" /idTUdmin="U863" /TUdmin="-989" /isTUend="FALSE" /label="downshifts" CDS complement(1098321..1098722) /gene="gerPE" /locus_tag="BSU_10680" /old_locus_tag="BSU10680" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10715007" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10715007; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination protein" /protein_id="NP_388949.1" /db_xref="EnsemblGenomes-Gn:BSU10680" /db_xref="EnsemblGenomes-Tr:CAB12908" /db_xref="GOA:O06717" /db_xref="InterPro:IPR024496" /db_xref="SubtiList:BG13091" /db_xref="UniProtKB/Swiss-Prot:O06717" /translation="MLKRISRIRLVKFNSLGIASVFQVGDTNEIDMSVKVFAVQRSLS TFYHNEGSFNKKEYQIFQQQAVKPLPETGVQSAFCHEVPAIYVRSIKIQGVSASSVLH AGSASLIRGDARLKHIRQIQSPRSQSPAKNI*" /label="gerPE CDS" gene complement(1098321..1098722) /gene="gerPE" /locus_tag="BSU_10680" /old_locus_tag="BSU10680" /label="gerPE gene" CDS complement(1098722..1098898) /gene="gerPD" /locus_tag="BSU_10690" /old_locus_tag="BSU10690" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10715007" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10715007; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination protein" /protein_id="NP_388950.1" /db_xref="EnsemblGenomes-Gn:BSU10690" /db_xref="EnsemblGenomes-Tr:CAB12909" /db_xref="GOA:O06718" /db_xref="InterPro:IPR017257" /db_xref="SubtiList:BG13092" /db_xref="UniProtKB/Swiss-Prot:O06718" /translation="MIFTVINRSLEVGDIRMNGVSSSSVFHIGDTESIYLSSIFDTPP ESLIIGPFAPLAPE*" /label="gerPD CDS" gene complement(1098722..1098898) /gene="gerPD" /locus_tag="BSU_10690" /old_locus_tag="BSU10690" /label="gerPD gene" CDS complement(1098895..1099512) /gene="gerPC" /locus_tag="BSU_10700" /old_locus_tag="BSU10700" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10715007" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10715007; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination protein" /protein_id="NP_388951.1" /db_xref="EnsemblGenomes-Gn:BSU10700" /db_xref="EnsemblGenomes-Tr:CAB12910" /db_xref="GOA:O06719" /db_xref="InterPro:IPR019673" /db_xref="SubtiList:BG13093" /db_xref="UniProtKB/Swiss-Prot:O06719" /translation="MYDQSVSSYLQNLNSFVQQQAIHIQQLERQLKEIQTEMNTMKQR PATTIERVEYKFDQLKIERLDGTLNIGLNPTDPNSVQNFDVSQSTPQIGMMQQEESAQ LMQQIRQNVDMYLTEEIPDILEQLENQYDSRLDDTNRHHVIEDIRKQMDSRIHYYMSH IKKEENTPPAQYAEHIAEHVKRDVIRAVEHFLEHIPSEMKGDEQA*" /label="gerPC CDS" gene complement(1098895..1099512) /gene="gerPC" /locus_tag="BSU_10700" /old_locus_tag="BSU10700" /label="gerPC gene" CDS complement(1099535..1099768) /gene="gerPB" /locus_tag="BSU_10710" /old_locus_tag="BSU10710" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10715007" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10715007; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination protein" /protein_id="NP_388952.2" /db_xref="EnsemblGenomes-Gn:BSU10710" /db_xref="EnsemblGenomes-Tr:CAB12911" /db_xref="GOA:O06720" /db_xref="InterPro:IPR024255" /db_xref="SubtiList:BG13094" /db_xref="UniProtKB/Swiss-Prot:O06720" /translation="MNFYINQTIQINYLRLESISNSSILQIGSAGSIKSLSNLYNTGS YVEPAPEVSGSGQPLQLQEPDTGSLVPLQPPGR*" /label="gerPB CDS" gene complement(1099535..1099768) /gene="gerPB" /locus_tag="BSU_10710" /old_locus_tag="BSU10710" /label="gerPB gene" CDS complement(1099783..1100004) /gene="gerPA" /locus_tag="BSU_10720" /old_locus_tag="BSU10720" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10715007" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10715007; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination protein" /protein_id="NP_388953.1" /db_xref="EnsemblGenomes-Gn:BSU10720" /db_xref="EnsemblGenomes-Tr:CAB12912" /db_xref="GOA:O06721" /db_xref="InterPro:IPR019618" /db_xref="SubtiList:BG13095" /db_xref="UniProtKB/Swiss-Prot:O06721" /translation="MPAIVGAFKINAIGTSGVVHIGDCITISPQAQVRTFAGAGSFNT GDSLKVMNYQNATNVYDNDAVDQPIVANA*" /label="gerPA CDS" gene complement(1099783..1100004) /gene="gerPA" /locus_tag="BSU_10720" /old_locus_tag="BSU10720" /label="gerPA gene" S_feature complement(1100005..1100091) /Source="Nicolas_S_feature" /locus_tag="new_1150428_1150514_c" /HighExp="S6, S8, S7, S5, BT, B36, B60, G/S, Pyr, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="SigK" /TUlongPSig="0.992" /label="S380" promotor_-35 1100019..1100025 /Source="Nicolas_upshift_promotors" /id="U862" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig="0.733266733266733" /xcortree=136 /SigmaFactorBS="aaacgctccgacaatggccggcatacgagcacatccttTGTT GAAaaattaaaaaaagACAGGTAAAGTGAAATGACAattccgatttcaattgggctat t" /listShort="S381, S385" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1100039..1100058 /Source="Nicolas_upshift_promotors" /id="U862" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig="0.733266733266733" /xcortree=136 /SigmaFactorBS="aaacgctccgacaatggccggcatacgagcacatccttTGTT GAAaaattaaaaaaagACAGGTAAAGTGAAATGACAattccgatttcaattgggctat t" /listShort="S381, S385" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1100041..1100696 /Source="Nicolas_S_feature" /locus_tag="new_1150464_1151119" /HighExp="Salt, BC, Sw, S8, Heat, M9-stat, S7, Etha, BMM, Lbtran" /AntisenseName="yisI" /AntisenseCor="3.97396613023396E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="0.17396" /TUshortSig="SigA" /TUshortPSig="0.733" /TUlongSig="NA" /TUlongPSig="NA" /label="S381" upshifts 1100041 /Source="Nicolas_upshifts" /id="U862" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig="0.733266733266733" /xcortree=136 /SigmaFactorBS="aaacgctccgacaatggccggcatacgagcacatccttTGTT GAAaaattaaaaaaagACAGGTAAAGTGAAATGACAattccgatttcaattgggctat t" /listShort="S381, S385" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1100078..1100097) /Source="Nicolas_upshift_promotors" /id="U863" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1293 /SigmaFactorBS="ttcacaaagagccgatatgtccccttaaaattTCTCTCACAC atatgtgcgtttGTCATAAGCTATCGTGAATAgcccaattgaaatcggaattgtcatt t" /listShort="S380, gerPA, gerPB, gerPC, gerPD, gerPE, gerPF, S379" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1100091) /Source="Nicolas_upshifts" /id="U863" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1293 /SigmaFactorBS="ttcacaaagagccgatatgtccccttaaaattTCTCTCACAC atatgtgcgtttGTCATAAGCTATCGTGAATAgcccaattgaaatcggaattgtcatt t" /listShort="S380, gerPA, gerPB, gerPC, gerPD, gerPE, gerPF, S379" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1100093..1100222) /Source="Nicolas_S_feature" /locus_tag="new_1150516_1150645_c" /HighExp="S6, S8, S7, T5.0H, T3.30H, T4.0H, S5, T3.0H, T2.30H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S382" promotor_-35 complement(1100110..1100119) /Source="Nicolas_upshift_promotors" /id="U863" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1293 /SigmaFactorBS="ttcacaaagagccgatatgtccccttaaaattTCTCTCACAC atatgtgcgtttGTCATAAGCTATCGTGAATAgcccaattgaaatcggaattgtcatt t" /listShort="S380, gerPA, gerPB, gerPC, gerPD, gerPE, gerPF, S379" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1100224..1100426) /Source="Nicolas_S_feature" /locus_tag="new_1150647_1150849_c" /HighExp="T5.0H, T4.0H, T3.30H, S6, M9-stat, T3.0H, S8, S7, T2.30H, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.976, 0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S383" downshifts complement(1100267) /Source="Nicolas_upshifts" /id="D581" /incds=0 /nref=13 /ntot=116 /MaxReadThrough="3.97434" /MaxDrop="3.59184" /score="13.5435041" /energy="-15.3" /TU="U865" /idTUdmin="U864" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1100427..1100597) /gene="pchI" /locus_tag="BSU_10730" /old_locus_tag="BSU10730" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11679073, 27542896" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11679073, 27542896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Spo0A-P phosphatase (iron-metabolism related)" /protein_id="NP_388954.1" /db_xref="EnsemblGenomes-Gn:BSU10730" /db_xref="EnsemblGenomes-Tr:CAB12913" /db_xref="GOA:O06722" /db_xref="InterPro:IPR018540" /db_xref="InterPro:IPR037208" /db_xref="SubtiList:BG13096" /db_xref="UniProtKB/Swiss-Prot:O06722" /translation="MNSKIEEMRITLIETAQKYGMNSKETIQCSQELDILLNTRIKEE MIFGRYLENSRM*" /label="pchI CDS" gene complement(1100427..1100597) /gene="pchI" /locus_tag="BSU_10730" /old_locus_tag="BSU10730" /label="pchI gene" misc_feature complement(1100641..1100660) /Source="Nicolas_upshift_promotors" /id="U864" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.386613386613387" /psig="0.976023976023976" /xcortree=2921 /SigmaFactorBS="gcttttttagtcaaattgacgaaaggcaaccttttgagccaa aaTAGGTTATACTAACGATATCctgtatttatatcaaaataaaatctagaattggaga t" /listShort="yisI, S383" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1100644) /Source="Nicolas_upshifts" /id="U864" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.386613386613387" /psig="0.976023976023976" /xcortree=2921 /SigmaFactorBS="gcttttttagtcaaattgacgaaaggcaaccttttgagccaa aaTAGGTTATACTAACGATATCctgtatttatatcaaaataaaatctagaattggaga t" /listShort="yisI, S383" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1100646..1100742) /Source="Nicolas_S_feature" /locus_tag="new_1151069_1151165_c" /HighExp="S6, S8, S7, S5, BT, Pyr, G/S, Glucon, SMMPr, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S384" downshifts 1100653 /Source="Nicolas_upshifts" /id="D582" /incds=0 /nref=3 /ntot=54 /MaxReadThrough="4.52913" /MaxDrop="3.35342" /score="12.6645711" /energy="-10.3" /TU="U862" /idTUdmin="U862" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" S_feature 1100698..1100862 /Source="Nicolas_S_feature" /locus_tag="new_1151121_1151285" /HighExp="Salt, S8, S7, BC, Heat, H2O2, Sw, Oxctl, MG-0.2, MG-0.1" /AntisenseName="yisJ" /AntisenseCor="0.24461808844813801" /AntisenseRegPval="-4.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.733" /TUlongSig="NA" /TUlongPSig="NA" /label="S385" CDS complement(1100743..1101666) /gene="yisJ" /locus_tag="BSU_10740" /old_locus_tag="BSU10740" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative spore coat protein, CotH paralog" /protein_id="NP_388955.1" /db_xref="EnsemblGenomes-Gn:BSU10740" /db_xref="EnsemblGenomes-Tr:CAB12914" /db_xref="GOA:O06723" /db_xref="InterPro:IPR014867" /db_xref="SubtiList:BG13097" /db_xref="UniProtKB/Swiss-Prot:O06723" /translation="MERVHLFFHREQLKRKGTAKGLFVTDRSVSPILLTQRDRAEKAS YEISWEKSLLGERTLFLNAEQDDPSLMRRRLAYCFFDQIGVPAPVASYSFLTINGQPE GIYLNIKNHQPAGKRSYGVKTADPRVPLSLFNNDSSAFLHEFFILIRTAGDDELAERI KLYLDVKLFFLWLIGNTCTNQGFYYTFCLNESGRLYVSPMETRSLAVQEWYEEDPLLT KGKTLSSRLLSIPAFRSQYHTLMKNVLKRSFTIERLSPLINEWHLDICQSAADDPFIK KSPFQIEKEQTNILREIEERQDFLQAHLARL*" /label="yisJ CDS" gene complement(1100743..1101666) /gene="yisJ" /locus_tag="BSU_10740" /old_locus_tag="BSU10740" /label="yisJ gene" promotor_-10 complement(1101688..1101707) /Source="Nicolas_upshift_promotors" /id="U865" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1372 /SigmaFactorBS="aaatccctttttctcaattccgttttcatTTCGTTTCAGgac gggcttgctcTACATATCATACAAATGTCGttttgagaaggaggaaagaatatggagc g" /listShort="yisJ, S384, yisI, S383, S382" /listLong="S380, gerPA, gerPB, gerPC, gerPD, gerPE, gerPF, S379" /label="promotor_-10" upshifts complement(1101699) /Source="Nicolas_upshifts" /id="U865" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1372 /SigmaFactorBS="aaatccctttttctcaattccgttttcatTTCGTTTCAGgac gggcttgctcTACATATCATACAAATGTCGttttgagaaggaggaaagaatatggagc g" /listShort="yisJ, S384, yisI, S383, S382" /listLong="S380, gerPA, gerPB, gerPC, gerPD, gerPE, gerPF, S379" /label="upshifts" promotor_-35 complement(1101721..1101730) /Source="Nicolas_upshift_promotors" /id="U865" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1372 /SigmaFactorBS="aaatccctttttctcaattccgttttcatTTCGTTTCAGgac gggcttgctcTACATATCATACAAATGTCGttttgagaaggaggaaagaatatggagc g" /listShort="yisJ, S384, yisI, S383, S382" /listLong="S380, gerPA, gerPB, gerPC, gerPD, gerPE, gerPF, S379" /label="promotor_-35" promotor_-35 1101750..1101758 /Source="Nicolas_upshift_promotors" /id="U866" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=553 /SigmaFactorBS="cccgtcctgaaacgaaatgaaaacggaattgagaaAAAGGGA TTtcagcattcgaCAGAGAATACATGAAGGAGcattctgatttaaaagatgatggagg a" /listShort="yisK, S386, yisL" /listLong="wprA" /label="promotor_-35" promotor_-10 1101770..1101788 /Source="Nicolas_upshift_promotors" /id="U866" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=553 /SigmaFactorBS="cccgtcctgaaacgaaatgaaaacggaattgagaaAAAGGGA TTtcagcattcgaCAGAGAATACATGAAGGAGcattctgatttaaaagatgatggagg a" /listShort="yisK, S386, yisL" /listLong="wprA" /label="promotor_-10" upshifts 1101775 /Source="Nicolas_upshifts" /id="U866" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=553 /SigmaFactorBS="cccgtcctgaaacgaaatgaaaacggaattgagaaAAAGGGA TTtcagcattcgaCAGAGAATACATGAAGGAGcattctgatttaaaagatgatggagg a" /listShort="yisK, S386, yisL" /listLong="wprA" /label="upshifts" CDS 1101821..1102726 /gene="mblK" /locus_tag="BSU_10750" /old_locus_tag="BSU10750" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16847875, 27215790, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16847875, 27215790, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="hydrolase/isomerase involved in remodelling the bacterial envelope" /protein_id="NP_388956.1" /db_xref="EnsemblGenomes-Gn:BSU10750" /db_xref="EnsemblGenomes-Tr:CAB12915" /db_xref="GOA:O06724" /db_xref="InterPro:IPR011234" /db_xref="InterPro:IPR036663" /db_xref="SubtiList:BG13098" /db_xref="UniProtKB/Swiss-Prot:O06724" /translation="MKFATGELYNRMFVGLIIDDEKIMDLQKAEKKLFELETIPGSLI ECIAEGDKFVAHARQLAEWAKKPNDELGSFMYSLSEVKLHAPIPKPSKNIICIGKNYR DHAIEMGSEADIPEHPMVFTKSPVTVTGHGDIVKSHEEVTSQLDYEGELAVVIGKSGT RISKEDAYDHVFGYTIVNDITARDLQKRHKQFFIGKSLDTTCPMGPVLVHKSSIQEPE RLKVETRVNGELRQSGSASDMIFSIPELIETLSKGMTLEAGDIIATGTPSGVGKGFTP PKFLRSGDKIDITIDPIGTLSNQIG*" /label="mblK CDS" gene 1101821..1102726 /gene="mblK" /locus_tag="BSU_10750" /old_locus_tag="BSU10750" /label="mblK gene" S_feature 1102727..1102807 /Source="Nicolas_S_feature" /locus_tag="new_1153150_1153230" /HighExp="S2, Lbstat, S1, Etha, SMMPr, M0t90, M40t90, LoTm, T-4.40H, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S386" promotor_-35 1102777..1102780 /Source="Nicolas_upshift_promotors" /id="U867" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.851148851148851" /psig=1 /xcortree=2462 /SigmaFactorBS="gacccgcccgttttttctgataatcatcTTTGtgacagagga caagttCATGGTACTATAAGTGGGGTaatttatctgatagggggaacatatatgacac a" /listShort="yisL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1102797..1102816 /Source="Nicolas_upshift_promotors" /id="U867" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.851148851148851" /psig=1 /xcortree=2462 /SigmaFactorBS="gacccgcccgttttttctgataatcatcTTTGtgacagagga caagttCATGGTACTATAAGTGGGGTaatttatctgatagggggaacatatatgacac a" /listShort="yisL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1102809 /Source="Nicolas_upshifts" /id="U867" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.851148851148851" /psig=1 /xcortree=2462 /SigmaFactorBS="gacccgcccgttttttctgataatcatcTTTGtgacagagga caagttCATGGTACTATAAGTGGGGTaatttatctgatagggggaacatatatgacac a" /listShort="yisL" /GFF_Attribute="listLong" /label="upshifts" CDS 1102842..1103198 /gene="yisL" /locus_tag="BSU_10760" /old_locus_tag="BSU10760" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 27215790; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_388957.1" /db_xref="EnsemblGenomes-Gn:BSU10760" /db_xref="EnsemblGenomes-Tr:CAB12916" /db_xref="GOA:O06725" /db_xref="InterPro:IPR010899" /db_xref="SubtiList:BG13099" /db_xref="UniProtKB/Swiss-Prot:O06725" /translation="MTHLHITTWVVALILLFVSYSLYSSGSAKGAKITHMILRLFYIL IILTGAELFVRFANWNGEYAGKMILGIITIGLMEMLLIRKKKEKSTGGLWVGFVIVLL LTVLLGLHLPIGFQLF*" /label="yisL CDS" gene 1102842..1103198 /gene="yisL" /locus_tag="BSU_10760" /old_locus_tag="BSU10760" /label="yisL gene" downshifts 1103095 /Source="Nicolas_upshifts" /id="D583" /incds=1 /nref=1 /ntot=44 /MaxReadThrough="4.28837" /MaxDrop="2.46999" /score="41.4247437" /energy="-11.7" /TU="U866,U867" /idTUdmin="U867" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" downshifts 1103186 /Source="Nicolas_upshifts" /id="D584" /incds=0 /nref=17 /ntot=162 /MaxReadThrough="3.06092" /MaxDrop="3.41506" /score="41.4247437" /energy="-11.7" /TU="U866" /idTUdmin="U867" /TUdmin=3 /isTUend="TRUE" /label="downshifts" upshifts 1103319 /Source="Nicolas_upshifts" /id="U868" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.486513486513487" /psig="0.732267732267732" /xcortree=2782 /SigmaFactorBS="atattccaaatcatttaaaataaccttaaaattccctgtaag cggtatctcgtcctatgaaatTATGATACCTTCAAGGAGATtcattattttgcaggag g" /listShort="wprA" /GFF_Attribute="listLong" /label="upshifts" misc_feature 1103322..1103341 /Source="Nicolas_upshift_promotors" /id="U868" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.486513486513487" /psig="0.732267732267732" /xcortree=2782 /SigmaFactorBS="atattccaaatcatttaaaataaccttaaaattccctgtaag cggtatctcgtcctatgaaatTATGATACCTTCAAGGAGATtcattattttgcaggag g" /listShort="wprA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 1103366..1106050 /gene="wprA" /locus_tag="BSU_10770" /old_locus_tag="BSU10770" /EC_number="3.4.21.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9004506, 9675284, 10336490, 15205417, 17269748, 21636651, 23180473, 25313396" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9004506, 9675284, 10336490, 15205417, 17269748, 21636651, 23180473, 25313396; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cell wall-associated protease" /protein_id="NP_388958.1" /db_xref="EnsemblGenomes-Gn:BSU10770" /db_xref="EnsemblGenomes-Tr:CAB12917" /db_xref="GOA:P54423" /db_xref="InterPro:IPR000209" /db_xref="InterPro:IPR015500" /db_xref="InterPro:IPR022398" /db_xref="InterPro:IPR023828" /db_xref="InterPro:IPR034084" /db_xref="InterPro:IPR036852" /db_xref="SubtiList:BG11846" /db_xref="UniProtKB/Swiss-Prot:P54423" /translation="MKRRKFSSVVAAVLIFALIFSLFSPGTKAAAAGAIDQAAALENG KEQTGAMKEPEQVKWYKVTPGATDIQKNSHMALTVKSDSVLNVSVYPSKEKALKDETF EMYRSFTAEDGKSEVIFPYAWSGPYYVKVEYLGEEEPEDGGTAEAAAEAKYTIGYKGT KKQPSDLEEEEACPVEMSVDQKKSGKGILDKLRSIRDEQLSQTAEGKELTSLYYKAAP FIVAKLALNKTARNEIYQDLVTLKPLFDDVSENGASSSYKVTEKDQKAINRLYDKALQ SVPSFLKEEIKKQADRLNMKQLQGKTAGAILTENNIAAKSEVQTTKVIFKVKDNKSLS SVHNEMKGFSASAQSKKDISNVKKAKKLFDNLYSFELPKDEKQNGAYTASAKRVKSAA ATLSKMSNVEFAEPVQEYKSLANDIQYPYQWPLKNNGENGGVKNADVKYEPANTLLSK RKLNDTLIAVVDTGVDSTLADLKGKVRTDLGHNFVGRNNNAMDDQGHGTHVAGIIAAQ SDNGYSMTGLNAKAKIIPVKVLDSAGSGDTEQIALGIKYAADKGAKVINLSLGGGYSR VLEFALKYAADKNVLIAAASGNDGENALSYPASSKYVMSVGATNRMDMTADFSNYGKG LDISAPGSDIPSLVPNGNVTYMSGTSMATPYAAAAAGLLFAQNPKLKRTEVEDMLKKT ADDISFESVDGGEEELYDDYGDPIEIPKTPGVDWHSGYGRLNVMKAVSAADLQLKVNK LESTQTAVRGSAKEGTLIEVMNGKKKLGSAKAGKDNAFKVNIATQKQDQVLYLKATKG DAKTSYKVVVVKGKPSGTPKVNAVKTKDTAVKGKANSKAMIRVKNKSKKVIASAKADA KGTFSVKIKKQKAGTVLYVTAVDTDKKESKEAKVVVEK*" /label="wprA CDS" gene 1103366..1106050 /gene="wprA" /locus_tag="BSU_10770" /old_locus_tag="BSU10770" /label="wprA gene" downshifts complement(1103534) /Source="Nicolas_upshifts" /id="D585" /incds=1 /nref=2 /ntot=155 /MaxReadThrough="0.14981" /MaxDrop="3.98572" /score="9.01750245" /energy="-8" /TU="NA" /idTUdmin="U869" /TUdmin=2563 /isTUend="FALSE" /label="downshifts" downshifts 1106042 /Source="Nicolas_upshifts" /id="D586" /incds=0 /nref=239 /ntot=267 /MaxReadThrough="1.55031" /MaxDrop="8.31576" /score="36.3638154" /energy="-12.3" /TU="NA" /idTUdmin="U868" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1106081..1106668) /gene="yisN" /locus_tag="BSU_10780" /old_locus_tag="BSU10780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388959.1" /db_xref="EnsemblGenomes-Gn:BSU10780" /db_xref="EnsemblGenomes-Tr:CAB12918" /db_xref="InterPro:IPR024488" /db_xref="SubtiList:BG12239" /db_xref="UniProtKB/Swiss-Prot:O06727" /translation="MKKKETAWMKRKQLLYTEERKWEYGTILIEDGICLIENGEGDIL LADSLQHSPIWIHHKGKWEQAGFQDKLVLACGAENISLSGGERIRYEKSVKRPLMALL DSLDDETFLAFLQHLHSFGLSVFDCVFSYNKGVFSNTSAGQGVSFYHFSNDTAQCAMQ HHYNYSSEGTGDRFEWTASNGKRSIMYTAVQRGRK*" /label="yisN CDS" gene complement(1106081..1106668) /gene="yisN" /locus_tag="BSU_10780" /old_locus_tag="BSU10780" /label="yisN gene" promotor_-10 complement(1106683..1106702) /Source="Nicolas_upshift_promotors" /id="U869" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.561438561438561" /psig="0.561438561438561" /xcortree=1023 /SigmaFactorBS="caccttagtaagtttatgcatctataggcagatagttgattt GTCcataaaagagttgtaTGGGACAGGCTTGAATTGGAaagaaaagagaggaatgaag a" /listShort="yisN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1106702) /Source="Nicolas_upshifts" /id="U869" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.561438561438561" /psig="0.561438561438561" /xcortree=1023 /SigmaFactorBS="caccttagtaagtttatgcatctataggcagatagttgattt GTCcataaaagagttgtaTGGGACAGGCTTGAATTGGAaagaaaagagaggaatgaag a" /listShort="yisN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1106718..1106720) /Source="Nicolas_upshift_promotors" /id="U869" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.561438561438561" /psig="0.561438561438561" /xcortree=1023 /SigmaFactorBS="caccttagtaagtttatgcatctataggcagatagttgattt GTCcataaaagagttgtaTGGGACAGGCTTGAATTGGAaagaaaagagaggaatgaag a" /listShort="yisN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1106723..1106729 /Source="Nicolas_upshift_promotors" /id="U870" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.543456543456543" /psig="0.543456543456543" /xcortree=1061 /SigmaFactorBS="tttccaattcaagcctgtcccatacaactcttttatggacaa ATCAACTatctgcctatagatGCATAAACTTACTAAGGTGctgaaagaaacgaaattg t" /listShort="S387, asnO, S388" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1106741 /Source="Nicolas_upshifts" /id="U870" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.543456543456543" /psig="0.543456543456543" /xcortree=1061 /SigmaFactorBS="tttccaattcaagcctgtcccatacaactcttttatggacaa ATCAACTatctgcctatagatGCATAAACTTACTAAGGTGctgaaagaaacgaaattg t" /listShort="S387, asnO, S388" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1106744..1106762 /Source="Nicolas_upshift_promotors" /id="U870" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.543456543456543" /psig="0.543456543456543" /xcortree=1061 /SigmaFactorBS="tttccaattcaagcctgtcccatacaactcttttatggacaa ATCAACTatctgcctatagatGCATAAACTTACTAAGGTGctgaaagaaacgaaattg t" /listShort="S387, asnO, S388" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1106747..1106813 /Source="Nicolas_S_feature" /locus_tag="new_1157170_1157236" /HighExp="S6, S5, S7, S8, B36, S4, BT, G/S, B60, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.543" /TUlongSig="NA" /TUlongPSig="NA" /label="S387" CDS 1106814..1108658 /gene="asnO" /locus_tag="BSU_10790" /old_locus_tag="BSU10790" /EC_number="6.3.5.4" /function="16.5: Explore" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10498721, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10498721, 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="asparagine synthetase (sporulation related)" /protein_id="NP_388960.2" /db_xref="EnsemblGenomes-Gn:BSU10790" /db_xref="EnsemblGenomes-Tr:CAB12919" /db_xref="GOA:O05272" /db_xref="InterPro:IPR001962" /db_xref="InterPro:IPR006426" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR017932" /db_xref="InterPro:IPR029055" /db_xref="InterPro:IPR033738" /db_xref="SubtiList:BG12240" /db_xref="UniProtKB/Swiss-Prot:O05272" /translation="MCGITGWVDFKKQLVQEKQTMDRMTDTLSKRGPDDSNVWGEHHV LFGHKRLAVVDIEGGRQPMACTYKGDTYTIIYNGELYNTEDLRKELRARGHQFERTSD TEVLLHSYIEWQEDCVDHLNGIFAFAVWDEKRNLLFAARDRLGVKPFFYTKEGSSFLF GSEIKAILAHPDIKARVDRTGLSEIFGLGPSRTPGTGIFKGIKEIRPAHALTFSKDGL NIWRYWNVESEKHTDSFDDTVANVRSLFQDAVTRQLVSDVPVCTFLSGGLDSSAITAI AAGHFEKEGKAPLHTYSIDYEENDKYFQASAFQPNDDGPWIEKMTEAFGTTHHKCVIS QKDLVDHLEEAVLVKDLPGMADVDSSLLWFCREIKKDFVVSLSGECADEIFGGYPWFH TADVESGFPWMRSTEERIKLLSDSWQKKLNLKEYVNAKYEETLAETPLLDGETGVDKA RRQLFYLNMLWFMTNLLDRKDRMSMGASLEVRVPFADHRLVEYVWNIPWEMKMHDNRE KGILRKALEGILPDDILYRKKSPYPKTHHPEYTKGVSEWLKTIRSQKDSVLHTLLDRK QLDQLLETEGSSFKVPWFGQLMKGPQLIAHLAQIHTWFEAYRIDIDER*" /label="asnO CDS" gene 1106814..1108658 /gene="asnO" /locus_tag="BSU_10790" /old_locus_tag="BSU10790" /label="asnO gene" S_feature 1108659..1108726 /Source="Nicolas_S_feature" /locus_tag="new_1159082_1159149" /HighExp="S6, S5, S7, B36, BT, S8, S4, B60, S3, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.543" /TUlongSig="NA" /TUlongPSig="NA" /label="S388" downshifts 1108683 /Source="Nicolas_upshifts" /id="D587" /incds=0 /nref=12 /ntot=43 /MaxReadThrough="3.29969" /MaxDrop="4.67478" /score="3.55879494" /energy="-14.8" /TU="U870" /idTUdmin="U870" /TUdmin="-550" /isTUend="FALSE" /label="downshifts" CDS complement(1108788..1109267) /gene="yizA" /locus_tag="BSU_10800" /old_locus_tag="BSU10800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein (sporulation related)" /protein_id="YP_054576.1" /db_xref="EnsemblGenomes-Gn:BSU10800" /db_xref="EnsemblGenomes-Tr:CAE01451" /db_xref="GOA:Q7WY73" /db_xref="InterPro:IPR007837" /db_xref="InterPro:IPR034660" /db_xref="PDB:2QE9" /db_xref="SubtiList:BG14187" /db_xref="UniProtKB/Swiss-Prot:Q7WY73" /translation="MMKFFEYNWQVRDQWFTWCHQLTTEELLKNRLGGVENILYTLFH IIDVEYSWIRAIQGKEDIAVQFADYQTLNKVKSLSNTFRTEIIDVLQTHSDQIKDELV SVPWETGVLYTRDEILHHIIAHEIHHIGQLSVWARELKLSPVSASFIGRTLKPIHSY* " /label="yizA CDS" gene complement(1108788..1109267) /gene="yizA" /locus_tag="BSU_10800" /old_locus_tag="BSU10800" /label="yizA gene" upshifts complement(1109287) /Source="Nicolas_upshifts" /id="U871" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.701298701298701" /psig="0.701298701298701" /xcortree=530 /SigmaFactorBS="caatcatcacttcattaatAGAGGAATCacggaaaaaaGGGC TAATTGTTATGATACatgatagtattggagtgagtttagtgatgaaattttttgaata t" /listShort="yizA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1109291..1109309) /Source="Nicolas_upshift_promotors" /id="U871" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.701298701298701" /psig="0.701298701298701" /xcortree=530 /SigmaFactorBS="caatcatcacttcattaatAGAGGAATCacggaaaaaaGGGC TAATTGTTATGATACatgatagtattggagtgagtttagtgatgaaattttttgaata t" /listShort="yizA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1109320..1109328) /Source="Nicolas_upshift_promotors" /id="U871" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.701298701298701" /psig="0.701298701298701" /xcortree=530 /SigmaFactorBS="caatcatcacttcattaatAGAGGAATCacggaaaaaaGGGC TAATTGTTATGATACatgatagtattggagtgagtttagtgatgaaattttttgaata t" /listShort="yizA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1109459..1109463 /Source="Nicolas_upshift_promotors" /id="U872" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.338661338661339" /psig="0.988011988011988" /xcortree=2373 /SigmaFactorBS="tgcgtcttgttacttttacaaagtaagaatcggcattttctt cATATAcaattaggaaaaaaCATACTAGACTTGAAGAAGCagtgatacataggagtga g" /listShort="yisP" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1109476 /Source="Nicolas_upshifts" /id="U872" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.338661338661339" /psig="0.988011988011988" /xcortree=2373 /SigmaFactorBS="tgcgtcttgttacttttacaaagtaagaatcggcattttctt cATATAcaattaggaaaaaaCATACTAGACTTGAAGAAGCagtgatacataggagtga g" /listShort="yisP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1109478..1109497 /Source="Nicolas_upshift_promotors" /id="U872" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.338661338661339" /psig="0.988011988011988" /xcortree=2373 /SigmaFactorBS="tgcgtcttgttacttttacaaagtaagaatcggcattttctt cATATAcaattaggaaaaaaCATACTAGACTTGAAGAAGCagtgatacataggagtga g" /listShort="yisP" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1109499..1110323 /gene="farP" /locus_tag="BSU_10810" /old_locus_tag="BSU10810" /EC_number="3.6.1.27" /experiment="publication(s) with functional evidences, PMID:23295493, 25308276" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23295493, 25308276; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="farnesyl diphosphate phosphatase" /protein_id="NP_388961.1" /db_xref="EnsemblGenomes-Gn:BSU10810" /db_xref="EnsemblGenomes-Tr:CAB12920" /db_xref="GOA:O06728" /db_xref="InterPro:IPR002060" /db_xref="InterPro:IPR008949" /db_xref="PDB:3WE9" /db_xref="SubtiList:BG12241" /db_xref="UniProtKB/Swiss-Prot:O06728" /translation="MIHRSEKMKEIKEAYQQCGQIVGEYAPACFKALSYLPLKQRQAS WAVLSFCHTAASADEKVLPAFEAKADHVYQRTNNGKQHLWKAFDHAYRTFTLESEPFR EFIAAQKEDAKPYDDLDELLMYAYRTGGAAGLMLLPILTRRKQDQLKQAAVSLGLAIQ LVRFLSDLGTDQQKNRIPRQVMQQFGYTEADLQKGTVNKAFTMTWEYIAFEAEAYLEE CQDALPLFPQYSQKTVKAALHLHRAVLEKIRAKQHDVFQYHFALTETEVKQILSDI*" /label="farP CDS" gene 1109499..1110323 /gene="farP" /locus_tag="BSU_10810" /old_locus_tag="BSU10810" /label="farP gene" promotor_-35 1109711..1109717 /Source="Nicolas_upshift_promotors" /id="U873" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=261 /SigmaFactorBS="gtattgcccgcatttgaagctaaagctgatcaTGTTTACcaa aggacaaataaCGGTAAACAACATCTATGGaaggcttttgatcatgcgtatcggacct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1109732..1109750 /Source="Nicolas_upshift_promotors" /id="U873" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=261 /SigmaFactorBS="gtattgcccgcatttgaagctaaagctgatcaTGTTTACcaa aggacaaataaCGGTAAACAACATCTATGGaaggcttttgatcatgcgtatcggacct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1109739 /Source="Nicolas_upshifts" /id="U873" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=261 /SigmaFactorBS="gtattgcccgcatttgaagctaaagctgatcaTGTTTACcaa aggacaaataaCGGTAAACAACATCTATGGaaggcttttgatcatgcgtatcggacct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature 1110333..1111783 /Source="Nicolas_S_feature" /locus_tag="new_1160756_1162206" /HighExp="Salt, Etha, Sw, Cold, G150, G180, G135, LBGtran, Heat, Paraq" /AntisenseName="yisQ" /AntisenseCor="0.19511630802652" /AntisenseRegPval="-2.9" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S389" CDS complement(1110353..1111720) /gene="yisQ" /locus_tag="BSU_10820" /old_locus_tag="BSU10820" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 17114254; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na(+)-driven efflux transporter" /protein_id="NP_388962.1" /db_xref="EnsemblGenomes-Gn:BSU10820" /db_xref="EnsemblGenomes-Tr:CAB12921" /db_xref="GOA:O07940" /db_xref="InterPro:IPR002528" /db_xref="SubtiList:BG12242" /db_xref="UniProtKB/Swiss-Prot:O07940" /translation="MKQAVFKSTALKKPADKTFSLFSLTWPIFIEVSLYMFMGNADTL MLSQYSDNSVAAVGVSNQILNLIIVMFSFIATGTTVIISQFLGSRQKKEAMEVAYVSI GANFFISLAISAVVFFAAVPLLHMMGLSDALMPDAKVFLQVVGGLSFIQALIMTFSAI LKSYGYTKDTMFVTIGMNILNIAGNFVVIFGLFGFPVLGVAGVAMSTSIARVIGLIAM IVIVNKRIQLKMSLKKVFHMHKEHLRKLLKIGIPSAGEQLSYNLSQMIVTYFIAIMGA QALTTKVYTQNITMFILLFGTAISQGTQILIGRYIGGKQFDAAYERCMKSLYWALGIA AATSVLMTIFSKDLIGLFTQSPDIIATASLLIAMTIILEPGRSFNVIIINSLRAAGDA KFPVYMAMISMWGIGLPLAYLFGIHLGFGLAGIWISFIADEWVRGILMYRRWRSRIWI QKGMA*" /label="yisQ CDS" gene complement(1110353..1111720) /gene="yisQ" /locus_tag="BSU_10820" /old_locus_tag="BSU10820" /label="yisQ gene" promotor_-35 1111752..1111759 /Source="Nicolas_upshift_promotors" /id="U874" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.993006993006993" /xcortree=2737 /SigmaFactorBS="tctaacccctttcgtaaataaaatcaaCGTTTTAAagtgtac ctccatTTCCTTATAATAAAAAGGGAtagaaacgatacttcttgtaaaaatccgactt a" /listShort="yisR, degA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1111773..1111792 /Source="Nicolas_upshift_promotors" /id="U874" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.993006993006993" /xcortree=2737 /SigmaFactorBS="tctaacccctttcgtaaataaaatcaaCGTTTTAAagtgtac ctccatTTCCTTATAATAAAAAGGGAtagaaacgatacttcttgtaaaaatccgactt a" /listShort="yisR, degA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1111785 /Source="Nicolas_upshifts" /id="U874" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.993006993006993" /xcortree=2737 /SigmaFactorBS="tctaacccctttcgtaaataaaatcaaCGTTTTAAagtgtac ctccatTTCCTTATAATAAAAAGGGAtagaaacgatacttcttgtaaaaatccgactt a" /listShort="yisR, degA" /GFF_Attribute="listLong" /label="upshifts" CDS 1111844..1112707 /gene="yisR" /locus_tag="BSU_10830" /old_locus_tag="BSU10830" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10704478; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (AraC/XylS family)" /protein_id="NP_388963.1" /db_xref="EnsemblGenomes-Gn:BSU10830" /db_xref="EnsemblGenomes-Tr:CAB12922" /db_xref="GOA:P40331" /db_xref="InterPro:IPR003313" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR018060" /db_xref="InterPro:IPR018062" /db_xref="SubtiList:BG11064" /db_xref="UniProtKB/Swiss-Prot:P40331" /translation="MPRILFTVPPFPVFIAAGEGVFKKGETHVKRVFSVFDLIYVKQG TLYITENETSFSVEGGEYILLSPGLEHYGTKGSDEATSYYWLHFDEHRYEFTAKGGSN WSELQQEKGSFEELARYGLALPRKGKVQRPQFMAQQFEKLIDYSAENSDLPLRKQILF EELMLHLQKEAFQIPSAKERVAWEAARYLQEHYKEKTTIKDLSLALHYHQDYVSRCMQ QVLGVTPAQYTNRVRMTEAKRLLSSTNDKMGVIAETVGMEDPTYFSKLFKQIEGISPI EYRKIVSRKVQ*" /label="yisR CDS" gene 1111844..1112707 /gene="yisR" /locus_tag="BSU_10830" /old_locus_tag="BSU10830" /label="yisR gene" CDS 1112725..1113738 /gene="iolQ" /locus_tag="BSU_10840" /old_locus_tag="BSU10840" /function="16.6: Maintain" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8407808, 23504016, 28693424" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8407808, 23504016, 28693424; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of iolX (LacI family)" /protein_id="NP_388964.1" /db_xref="EnsemblGenomes-Gn:BSU10840" /db_xref="EnsemblGenomes-Tr:CAB12923" /db_xref="GOA:P37947" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG10847" /db_xref="UniProtKB/Swiss-Prot:P37947" /translation="MKTTIYDVAKAAGVSITTVSRVINNTGRISDKTRQKVMNVMNEM AYTPNVHAAALTGKRTNMIALVAPDISNPFYGELAKSIEERADELGFQMLICSTDYDP KKETKYFSVLKQKKVDGIIFATGIESHDSMSALEEIASEQIPIAMISQDKPLLPMDIV VIDDVRGGYEAAKHLLSLGHTNIACIIGDGSTTGEKNRIKGFRQAMEEAGVPIDESLI IQTRFSLESGKEEAGKLLDRNAPTAIFAFNDVLACAAIQAARIRGIKVPDDLSIIGFD NTILAEMAAPPLTTVAQPIKEMGRSVIELLAEAIEGKRKAKQKIVLPPELVVRHSTSP LNT*" /label="iolQ CDS" gene 1112725..1113738 /gene="iolQ" /locus_tag="BSU_10840" /old_locus_tag="BSU10840" /label="iolQ gene" downshifts 1113721 /Source="Nicolas_upshifts" /id="D588" /incds=0 /nref=13 /ntot=204 /MaxReadThrough="0.51227" /MaxDrop="3.29173" /score="25.1260914" /energy="-9.6" /TU="NA" /idTUdmin="U874" /TUdmin=22 /isTUend="TRUE" /label="downshifts" promotor_-35 1113790..1113797 /Source="Nicolas_upshift_promotors" /id="U875" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.91008991008991" /psig="0.988011988011988" /xcortree=334 /SigmaFactorBS="agttgaagccaaaaaaacaTATTGCGTgtaaaccaaaggcgG TGTAAAATATAACCATCTTttgagaaagcgcttgcgcaaaatggcagagcggatagaa c" /listShort="S390, yisS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1113812..1113831 /Source="Nicolas_upshift_promotors" /id="U875" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.91008991008991" /psig="0.988011988011988" /xcortree=334 /SigmaFactorBS="agttgaagccaaaaaaacaTATTGCGTgtaaaccaaaggcgG TGTAAAATATAACCATCTTttgagaaagcgcttgcgcaaaatggcagagcggatagaa c" /listShort="S390, yisS" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1113831..1113946 /Source="Nicolas_S_feature" /locus_tag="new_1164254_1164369" /HighExp="Lbstat, M40t90, M0t90, BI, G150, dia0, Mt0, Lbexp, Lbtran, dia5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S390" upshifts 1113831 /Source="Nicolas_upshifts" /id="U875" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.91008991008991" /psig="0.988011988011988" /xcortree=334 /SigmaFactorBS="agttgaagccaaaaaaacaTATTGCGTgtaaaccaaaggcgG TGTAAAATATAACCATCTTttgagaaagcgcttgcgcaaaatggcagagcggatagaa c" /listShort="S390, yisS" /GFF_Attribute="listLong" /label="upshifts" CDS 1113947..1114975 /gene="iolX" /locus_tag="BSU_10850" /old_locus_tag="BSU10850" /EC_number="1.1.1.370" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11160890, 20133360, 23109554, 23504016, 28693424" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11160890, 20133360, 23109554, 23504016, 28693424; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="scyllo-inositol 2-dehydrogenase (NAD(+))" /protein_id="NP_388965.1" /db_xref="EnsemblGenomes-Gn:BSU10850" /db_xref="EnsemblGenomes-Tr:CAB12924" /db_xref="GOA:P40332" /db_xref="InterPro:IPR000683" /db_xref="InterPro:IPR004104" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11065" /db_xref="UniProtKB/Swiss-Prot:P40332" /translation="MEHQVRCAVLGLGRLGYYHAKNLVTSVPGAKLVCVGDPLKGRAE QVARELGIEKWSEDPYEVLEDPGIDAVIIVTPTSTHGDMIIKAAENGKQIFVEKPLTL SLEESKAASEKVKETGVICQVGFMRRFDPAYADAKRRIDAGEIGKPIYYKGFTRDQGA PPAEFIKHSGGIFIDCSIHDYDIARYLLGAEITSVSGHGRILNNPFMEQYGDVDQALT YIEFDSGAAGDVEASRTSPYGHDIRAEVIGTEGSIFIGTLRHQHVTILSAKGSSFDII PDFQTRFHEAYCLELQHFAECVRNGKTPIVTDIDATINLEVGIAATNSFRNGMPVQLD VKRAYTGM*" /label="iolX CDS" gene 1113947..1114975 /gene="iolX" /locus_tag="BSU_10850" /old_locus_tag="BSU10850" /label="iolX gene" downshifts 1114997 /Source="Nicolas_upshifts" /id="D589" /incds=0 /nref=4 /ntot=37 /MaxReadThrough="0.33001" /MaxDrop="3.45406" /score="8.69111487" /energy="-13.4" /TU="NA" /idTUdmin="U875" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1115026..1115535) /gene="yisT" /locus_tag="BSU_10860" /old_locus_tag="BSU10860" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 25651892; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative enzyme regulator of activity" /protein_id="NP_388966.2" /db_xref="EnsemblGenomes-Gn:BSU10860" /db_xref="EnsemblGenomes-Tr:CAB12925" /db_xref="GOA:O07939" /db_xref="InterPro:IPR007837" /db_xref="InterPro:IPR034660" /db_xref="SubtiList:BG12243" /db_xref="UniProtKB/Swiss-Prot:O07939" /translation="MTDAKQFYDYHSWANKKIFTHIENLPEETAYQEVKSVFPSVSDV LLHMCRADYIWLNVLSGVAYQEIIDSAGKLQSAQGNMAAIKQHAAELESQYHDFFSRQ TDLEQTFTMQHPKLGTLESTYADTILHVVNHGTYHRGNVTAMLRQLDHSGVPTDYMYY LYEKRESKG*" /label="yisT CDS" gene complement(1115026..1115535) /gene="yisT" /locus_tag="BSU_10860" /old_locus_tag="BSU10860" /label="yisT gene" downshifts complement(1115045) /Source="Nicolas_upshifts" /id="D590" /incds=0 /nref=81 /ntot=251 /MaxReadThrough="-0.0416600000000003" /MaxDrop="7.15629" /score="27.2292301" /energy="-13.4" /TU="NA" /idTUdmin="U876" /TUdmin="-16" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1115548..1115566) /Source="Nicolas_upshift_promotors" /id="U876" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=520 /SigmaFactorBS="agcggcaggatattttggggtgtcactcttttgcaattGAAG GAGAAacagatgaaaaAAACGAATTTCTTAGAAAAgggggcatgctgatgactgatgc a" /listShort="yisT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1115564) /Source="Nicolas_upshifts" /id="U876" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=520 /SigmaFactorBS="agcggcaggatattttggggtgtcactcttttgcaattGAAG GAGAAacagatgaaaaAAACGAATTTCTTAGAAAAgggggcatgctgatgactgatgc a" /listShort="yisT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1115578..1115586) /Source="Nicolas_upshift_promotors" /id="U876" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=520 /SigmaFactorBS="agcggcaggatattttggggtgtcactcttttgcaattGAAG GAGAAacagatgaaaaAAACGAATTTCTTAGAAAAgggggcatgctgatgactgatgc a" /listShort="yisT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1115585..1116247) /gene="yisU" /locus_tag="BSU_10870" /old_locus_tag="BSU10870" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative aminoacid related metabolite efflux transporter" /protein_id="NP_388967.1" /db_xref="EnsemblGenomes-Gn:BSU10870" /db_xref="EnsemblGenomes-Tr:CAB12926" /db_xref="GOA:O06730" /db_xref="InterPro:IPR001123" /db_xref="SubtiList:BG13100" /db_xref="UniProtKB/Swiss-Prot:O06730" /translation="MTISLMIEKKCERSFFSMNAIIHGIVLAFGLILPLGVQNVFIFQ QGALQKHIWRALPAVISASVCDTLLIVLAVAGVSVIVQELPVFETVMMAGGFLFLLYM GWVTWNIRPNTSQNEKHTFTPKKQAAFAAAVSLLNPHAILDTIGVIGTSSLQYSGLEK WLFMAACIAVSWIWFISLAIAGRLFQTIDTSGRLMLIVNKCSAAVMWAAAGYFGVSLF CN*" /label="yisU CDS" gene complement(1115585..1116247) /gene="yisU" /locus_tag="BSU_10870" /old_locus_tag="BSU10870" /label="yisU gene" promotor_-35 1116266..1116272 /Source="Nicolas_upshift_promotors" /id="U877" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.5004995004995" /psig=1 /xcortree=3135 /SigmaFactorBS="gagagattgtcactaaagtctccagccatttGGTTGGGttag gaaccagccAAATGTATAATGTGTAAAAAaggggggcatgaccttgtcgcaatggcag c" /listShort="yisV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1116286..1116305 /Source="Nicolas_upshift_promotors" /id="U877" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.5004995004995" /psig=1 /xcortree=3135 /SigmaFactorBS="gagagattgtcactaaagtctccagccatttGGTTGGGttag gaaccagccAAATGTATAATGTGTAAAAAaggggggcatgaccttgtcgcaatggcag c" /listShort="yisV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1116295 /Source="Nicolas_upshifts" /id="U877" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.5004995004995" /psig=1 /xcortree=3135 /SigmaFactorBS="gagagattgtcactaaagtctccagccatttGGTTGGGttag gaaccagccAAATGTATAATGTGTAAAAAaggggggcatgaccttgtcgcaatggcag c" /listShort="yisV" /GFF_Attribute="listLong" /label="upshifts" CDS 1116314..1117768 /gene="yisV" /locus_tag="BSU_10880" /old_locus_tag="BSU10880" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15223311, 19383706; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative PLP-dependent transcriptional regulator" /protein_id="NP_388968.2" /db_xref="EnsemblGenomes-Gn:BSU10880" /db_xref="EnsemblGenomes-Tr:CAB12927" /db_xref="GOA:Q796Q6" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13101" /db_xref="UniProtKB/Swiss-Prot:Q796Q6" /translation="MTLSQWQPSRKSDVPLHRQIEQYMKDKILHGEWAVGTKIPSQRT LADMFQVNRSTVTAAIDELTSQGLLEGRKGGGTKVVNSTWSVLTAEPPLDWSDYVRSG IHRANSSIIQAINQNEPRADIIRLGTGELSPDLVPADTIGRMFQQINPGVLSLGYEQP KGNRQLREAVADHLKGKKIHVSPSAILIVSGALQALQLISIGLLKRDSVILTEKPSYL QSLHVFQSAGMRLRGLPMDDEGVKAGLVSSNRKQYGGQLLYTIPSFHNPTGTVMSEQR RKEIISLSKKEQMPIIEDDAYGDLWFEEKPPQPLKAMDHEGNILYLGAFSKTVSPGLR IGWLAGPEPVIERLADIKMQTDYGSSGLSQWAAAEWLSQGYYEEHLTWVRRKLKERRD AAVHFLERYAGDIATWRIPAGGFYIWVTFHKNLPVSRFFYELLKRQVLVNPGYIYDGE DRNSIRLSYSYASLGDLETGIKAAAETARRLMMS*" /label="yisV CDS" gene 1116314..1117768 /gene="yisV" /locus_tag="BSU_10880" /old_locus_tag="BSU10880" /label="yisV gene" S_feature complement(1117623..1117775) /Source="Nicolas_S_feature" /locus_tag="new_1168046_1168198_c" /HighExp="Diami, Sw, C90, LBGstat, dia15, Paraq, dia5, BC, M40t45, Oxctl" /AntisenseName="yisV" /AntisenseCor="0.69858995161852" /AntisenseRegPval="-40" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S391" downshifts complement(1117658) /Source="Nicolas_upshifts" /id="D591" /incds=1 /nref=2 /ntot=84 /MaxReadThrough="2.36735" /MaxDrop="2.81041" /score="-5.131548" /energy="-17.3" /TU="NA" /idTUdmin="U879" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" CDS complement(1117776..1118414) /gene="yisX" /locus_tag="BSU_10890" /old_locus_tag="BSU10890" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388970.1" /db_xref="EnsemblGenomes-Gn:BSU10890" /db_xref="EnsemblGenomes-Tr:CAB12929" /db_xref="InterPro:IPR001646" /db_xref="SubtiList:BG13103" /db_xref="UniProtKB/Swiss-Prot:O06733" /translation="MNKIAIQKPNIPENLQTADFHDAVTQDDVISMHLFEDCTICGED IERLCVEKTVFRNVVFIDVSFRHIELTDVIFEKCDLSNADFSGAVIHRTSVKQSKMVG MNVAEATLRNVSFEECHGHFSSFSYSNMKQVRFDHCALMQSECSDTVLQQTHFDGCEL EGASFTGTSLQNMDISTCRFEQLHVSLDKLKGCKIAPEHAIAFARALGAVIV*" /label="yisX CDS" gene complement(1117776..1118414) /gene="yisX" /locus_tag="BSU_10890" /old_locus_tag="BSU10890" /label="yisX gene" S_feature complement(1118415..1118549) /Source="Nicolas_S_feature" /locus_tag="new_1168838_1168972_c" /HighExp="Diami, dia15, dia5, C90, BC, Paraq, LBGstat, Lbtran, HiOs, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S392" promotor_-35 1118463..1118468 /Source="Nicolas_upshift_promotors" /id="U878" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1110 /SigmaFactorBS="cctttgctgcccgaaaaacagaggcttccgggttcaatTTAA TAgatcgttaaggaaatTGATACATATAGTAAATCGtgaagagccttttcttggtaca g" /listShort="S393, yisY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1118484..1118502 /Source="Nicolas_upshift_promotors" /id="U878" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1110 /SigmaFactorBS="cctttgctgcccgaaaaacagaggcttccgggttcaatTTAA TAgatcgttaaggaaatTGATACATATAGTAAATCGtgaagagccttttcttggtaca g" /listShort="S393, yisY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1118485 /Source="Nicolas_upshifts" /id="U878" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1110 /SigmaFactorBS="cctttgctgcccgaaaaacagaggcttccgggttcaatTTAA TAgatcgttaaggaaatTGATACATATAGTAAATCGtgaagagccttttcttggtaca g" /listShort="S393, yisY" /GFF_Attribute="listLong" /label="upshifts" S_feature 1118495..1118619 /Source="Nicolas_S_feature" /locus_tag="new_1168918_1169042" /HighExp="S6, S5, S8, S7, S4, BT, B36, S3, G/S, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S393" promotor_-10 complement(1118535..1118554) /Source="Nicolas_upshift_promotors" /id="U879" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig="0.995004995004995" /xcortree=2078 /SigmaFactorBS="tcctgttccctttggctttttcggcctgtaaacGCCTTGACg tataggaagctttCCATTTATGCTTACAAAACAagcgggctgctgtaccaagaaaagg c" /listShort="S392, yisX, S391" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1118549) /Source="Nicolas_upshifts" /id="U879" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig="0.995004995004995" /xcortree=2078 /SigmaFactorBS="tcctgttccctttggctttttcggcctgtaaacGCCTTGACg tataggaagctttCCATTTATGCTTACAAAACAagcgggctgctgtaccaagaaaagg c" /listShort="S392, yisX, S391" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1118569..1118576) /Source="Nicolas_upshift_promotors" /id="U879" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig="0.995004995004995" /xcortree=2078 /SigmaFactorBS="tcctgttccctttggctttttcggcctgtaaacGCCTTGACg tataggaagctttCCATTTATGCTTACAAAACAagcgggctgctgtaccaagaaaagg c" /listShort="S392, yisX, S391" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1118620..1119426 /gene="yisY" /locus_tag="BSU_10900" /old_locus_tag="BSU10900" /EC_number="3.1.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22882546, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyl hydrolase or peroxidase" /protein_id="NP_388971.1" /db_xref="EnsemblGenomes-Gn:BSU10900" /db_xref="EnsemblGenomes-Tr:CAB12930" /db_xref="GOA:O06734" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR000639" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG13104" /db_xref="UniProtKB/Swiss-Prot:O06734" /translation="MGHYIKTEEHVTLFVEDIGHGRPIIFLHGWPLNHKMFEYQMNEL PKRGFRFIGVDLRGYGQSDRPWEGYDYDTMADDVKAVIYTLQLENAILAGFSMGGAIA IRYMARHEGADVDKLILLSAAAPAFTKRPGYPYGMRKQDIDDMIELFKADRPKTLADL GKQFFEKKVSPELRQWFLNLMLEASSYGTIHSGIALRDEDLRKELAAIKVPTLILHGR KDRIAPFDFAKELKRGIKQSELVPFANSGHGAFYEEKEKINSLIAQFSNS*" /label="yisY CDS" gene 1118620..1119426 /gene="yisY" /locus_tag="BSU_10900" /old_locus_tag="BSU10900" /label="yisY gene" downshifts 1119419 /Source="Nicolas_upshifts" /id="D592" /incds=0 /nref=4 /ntot=24 /MaxReadThrough="2.64682" /MaxDrop="5.60718" /score="8.70914085" /energy="-6.5" /TU="NA" /idTUdmin="U878" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1119454..1120053) /gene="yisZ" /locus_tag="BSU_10910" /old_locus_tag="BSU10910" /EC_number="2.7.1.25" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15383836; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative adenylylsulfate kinase" /protein_id="NP_388972.1" /db_xref="EnsemblGenomes-Gn:BSU10910" /db_xref="EnsemblGenomes-Tr:CAB12931" /db_xref="GOA:O06735" /db_xref="InterPro:IPR002891" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13105" /db_xref="UniProtKB/Swiss-Prot:O06735" /translation="MTHNPNIIWHPAAISKSDRQSLNGHKSCVLWFTGLSGSGKSVLA NAVDEKLYRKGIQSYVLDGDNIRHGLNKDLGFQTGDRIENIRRIGEVAKLFVDSGQMI LTAFISPFREDRDMVRALFPKGEFFEIYVKCPLHVCEQRDPKGLYKKARNGEIKHFTG IDSPYEAPLSPDFIIESDQTSISDGADLIINALQNRGII*" /label="yisZ CDS" gene complement(1119454..1120053) /gene="yisZ" /locus_tag="BSU_10910" /old_locus_tag="BSU10910" /label="yisZ gene" downshifts complement(1119473) /Source="Nicolas_upshifts" /id="D593" /incds=0 /nref=35 /ntot=44 /MaxReadThrough="1.69999" /MaxDrop="6.8011" /score="17.1506785" /energy="-7.3" /TU="NA" /idTUdmin="U880" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1120050..1121219) /gene="yitA" /locus_tag="BSU_10920" /old_locus_tag="BSU10920" /EC_number="2.7.7.4" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15383836; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sulfate adenylyltransferase" /protein_id="NP_388973.2" /db_xref="EnsemblGenomes-Gn:BSU10920" /db_xref="EnsemblGenomes-Tr:CAB12932" /db_xref="GOA:O06736" /db_xref="InterPro:IPR002650" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR020792" /db_xref="InterPro:IPR024951" /db_xref="InterPro:IPR025980" /db_xref="SubtiList:BG13106" /db_xref="UniProtKB/Swiss-Prot:O06736" /translation="MNGNEPHGGVLINRCDPACHFEGCACQAELDQLALSDLELIAIG GYSPLTGFLGEKDYHSVVKEMRLANGLPWSLPITLPVGEKTARQLSAGDHVKLVKDGV TYGMITVTDIYQPDKTQEALSVFKTNDPAHPGVKKLLARPDYYIGGPITVSSLPDKSF EQFYATPAETRAAFQKLGWKTIVGFQTRNPVHRAHEYIQKTALETVDGLLLHPLVGET KSDDIPSDIRMESYQALLNHYYPKDRVMLSVFPAAMRYAGPREAIFHALVRKNYGCTH FIVGRDHAGVGSYYGTYDAQNIFQSFTEEELGIKPLFFEHSFYCRKCGNMGTSKTCPH SPRDHIHLSGTKVRELLRQGKKPPKEFSRPEVAAVLIKGLHQQPVAIKQNSGELQ*" /label="yitA CDS" gene complement(1120050..1121219) /gene="yitA" /locus_tag="BSU_10920" /old_locus_tag="BSU10920" /label="yitA gene" S_feature complement(1121220..1121331) /Source="Nicolas_S_feature" /locus_tag="new_1171643_1171754_c" /HighExp="S6, S7, S8, BT, S5, B36, G/S, Pyr, SMMPr, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S394" CDS complement(1121332..1122042) /gene="yitB" /locus_tag="BSU_10930" /old_locus_tag="BSU10930" /EC_number="1.8.4.8" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15383836; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phospho-adenylylsulfate reductase" /protein_id="NP_388974.2" /db_xref="EnsemblGenomes-Gn:BSU10930" /db_xref="EnsemblGenomes-Tr:CAB12933" /db_xref="GOA:O06737" /db_xref="InterPro:IPR002500" /db_xref="InterPro:IPR004511" /db_xref="InterPro:IPR011798" /db_xref="InterPro:IPR014729" /db_xref="SubtiList:BG13107" /db_xref="UniProtKB/Swiss-Prot:O06737" /translation="MNETITYDTWNDMLSKQITDQLIDELDVLKWAYRTYGEKIVYAC SFGAEGMVLLDLISKINKNAHIIFLDTGLHFQETYELIETVKERYPGFAIQMLEPELS LTEQGTKYGGELWKHNPNLCCQLRKIEPLKKHLSGMTAWISGLRRDQSPTRKHIQYVN LDQKFELIKICPLIHWTWDDVWTYIRLHNLPYNKLHDQHYPSIGCEMCTLPSPDPNDE RAGRWAGREKTECGLHQE*" /label="yitB CDS" gene complement(1121332..1122042) /gene="yitB" /locus_tag="BSU_10930" /old_locus_tag="BSU10930" /label="yitB gene" promotor_-10 complement(1122086..1122105) /Source="Nicolas_upshift_promotors" /id="U880" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1285 /SigmaFactorBS="aatggttccgcacctcattttaggcgggcgcggcacctaaaA CCTGAACCTttatgcaaaaaaTGAATAGTCTGCCTATAACTcgatcaatagataaaaa a" /listShort="yitB, S394, yitA, yisZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1122108) /Source="Nicolas_upshifts" /id="U880" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1285 /SigmaFactorBS="aatggttccgcacctcattttaggcgggcgcggcacctaaaA CCTGAACCTttatgcaaaaaaTGAATAGTCTGCCTATAACTcgatcaatagataaaaa a" /listShort="yitB, S394, yitA, yisZ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1122118..1122127) /Source="Nicolas_upshift_promotors" /id="U880" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1285 /SigmaFactorBS="aatggttccgcacctcattttaggcgggcgcggcacctaaaA CCTGAACCTttatgcaaaaaaTGAATAGTCTGCCTATAACTcgatcaatagataaaaa a" /listShort="yitB, S394, yitA, yisZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1122157..1122166 /Source="Nicolas_upshift_promotors" /id="U881" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1286 /SigmaFactorBS="aggtgccgcgcccgcctaaaatgaggTGCGGAACCAttaaga gcccggcTGAATATGCTTTTTAGCAAAatggttttatgcccaaggagaggtagtatgc c" /listShort="yitC, yitD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1122180..1122199 /Source="Nicolas_upshift_promotors" /id="U881" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1286 /SigmaFactorBS="aggtgccgcgcccgcctaaaatgaggTGCGGAACCAttaaga gcccggcTGAATATGCTTTTTAGCAAAatggttttatgcccaaggagaggtagtatgc c" /listShort="yitC, yitD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1122191 /Source="Nicolas_upshifts" /id="U881" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1286 /SigmaFactorBS="aggtgccgcgcccgcctaaaatgaggTGCGGAACCAttaaga gcccggcTGAATATGCTTTTTAGCAAAatggttttatgcccaaggagaggtagtatgc c" /listShort="yitC, yitD" /GFF_Attribute="listLong" /label="upshifts" CDS 1122227..1122913 /gene="slpH" /locus_tag="BSU_10940" /old_locus_tag="BSU10940" /EC_number="3.1.3.71" /function="15.7: Sporulation and germination" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 3346220, 11830598, 15383836, 16341843; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-phospho,3-sulfolactate phosphatase (sporulation related)" /protein_id="NP_388975.1" /db_xref="EnsemblGenomes-Gn:BSU10940" /db_xref="EnsemblGenomes-Tr:CAB12934" /db_xref="GOA:O06738" /db_xref="InterPro:IPR005238" /db_xref="InterPro:IPR036702" /db_xref="SubtiList:BG13108" /db_xref="UniProtKB/Swiss-Prot:O06738" /translation="MPIAIYQGHHHSLAPADINIVIDVIRAFTVAHYAFIGGAKEILL VRTADEAFALKDTYPDYVLTGEEKGVGISGFDLDNSPKRMAGQNMTDKSLIQKTTNGV TAALGALNAKHLFVTGFSNAKTTAQHVKKLVANDCVINIVASHPSGDDDMACAEYIKG IIEGTNVVTAAEAIERIKGSSVAEKFFDCRQPLFDSEDIVYCTKELTGDFVMKVKQDG EVPTIERVII*" /label="slpH CDS" gene 1122227..1122913 /gene="slpH" /locus_tag="BSU_10940" /old_locus_tag="BSU10940" /label="slpH gene" CDS 1122910..1123668 /gene="slpS" /locus_tag="BSU_10950" /old_locus_tag="BSU10950" /EC_number="4.4.1.19" /function="16.14: Store" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 11830598, 15014443, 15383836; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-phospho-3-sulfolactate synthase" /protein_id="NP_388976.1" /db_xref="EnsemblGenomes-Gn:BSU10950" /db_xref="EnsemblGenomes-Tr:CAB12935" /db_xref="GOA:O06739" /db_xref="InterPro:IPR003830" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR036112" /db_xref="PDB:1U83" /db_xref="SubtiList:BG13109" /db_xref="UniProtKB/Swiss-Prot:O06739" /translation="MNDFSLELPVRTNKPRETGQSILIDNGYPLQFFKDAIAGASDYI DFVKFGWGTSLLTKDLEEKISTLKEHDITFFFGGTLFEKYVSQKKVNEFHRYCTYFGC EYIEISNGTLPMTNKEKAAYIADFSDEFLVLSEVGSKDAELASRQSSEEWLEYIVEDM EAGAEKVITEARESGTGGICSSSGDVRFQIVDDIISSDIDINRLIFEAPNKTLQQGFI QKIGPNVNLANIPFHDAIALETLRLGLRSDTFFL*" /label="slpS CDS" gene 1122910..1123668 /gene="slpS" /locus_tag="BSU_10950" /old_locus_tag="BSU10950" /label="slpS gene" downshifts 1123665 /Source="Nicolas_upshifts" /id="D594" /incds=0 /nref=2 /ntot=20 /MaxReadThrough="2.37654" /MaxDrop="4.17689" /score="-1.32868938" /energy="-17.6" /TU="NA" /idTUdmin="U881" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1123713..1124342) /gene="yitE" /locus_tag="BSU_10960" /old_locus_tag="BSU10960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 26335199; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388977.1" /db_xref="EnsemblGenomes-Gn:BSU10960" /db_xref="EnsemblGenomes-Tr:CAB12936" /db_xref="GOA:O06740" /db_xref="InterPro:IPR003740" /db_xref="SubtiList:BG13110" /db_xref="UniProtKB/Swiss-Prot:O06740" /translation="MAELLMKAKLTFMIVVGGVLQGLGMSLFLFPHDIPTGGAAGIAV LLHYLFQIPHGFSVWAVNVSMLFTALKWLEMRTFTGTLASITVTSVSVLIFDAVFPDI TSNLWLDLASGAVLLGLGIGLLYKYKISNGGFGALALMISIYRGGNPGTILLIMNCII FMVTASIIDWGIVIQALICQVISTRVIDFIYNIRLTSLPYLTPMYRHKK*" /label="yitE CDS" gene complement(1123713..1124342) /gene="yitE" /locus_tag="BSU_10960" /old_locus_tag="BSU10960" /label="yitE gene" promotor_-10 complement(1124376..1124394) /Source="Nicolas_upshift_promotors" /id="U882" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=996 /SigmaFactorBS="tggctcagcctattaagctgggccatttctttattttgaGAC ATAaataatggacagccTCATAAAATGAAAACAGCGgacaagtcttttcataaaggag c" /listShort="yitE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1124393) /Source="Nicolas_upshifts" /id="U882" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=996 /SigmaFactorBS="tggctcagcctattaagctgggccatttctttattttgaGAC ATAaataatggacagccTCATAAAATGAAAACAGCGgacaagtcttttcataaaggag c" /listShort="yitE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1124409..1124414) /Source="Nicolas_upshift_promotors" /id="U882" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=996 /SigmaFactorBS="tggctcagcctattaagctgggccatttctttattttgaGAC ATAaataatggacagccTCATAAAATGAAAACAGCGgacaagtcttttcataaaggag c" /listShort="yitE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1124438..1125553) /gene="yitF" /locus_tag="BSU_10970" /old_locus_tag="BSU10970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106, 11747447, 27994575; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enolase superfamily enzyme (isomerase /dehydratase)" /protein_id="NP_388978.1" /db_xref="EnsemblGenomes-Gn:BSU10970" /db_xref="EnsemblGenomes-Tr:CAB12937" /db_xref="GOA:O06741" /db_xref="InterPro:IPR013341" /db_xref="InterPro:IPR013342" /db_xref="InterPro:IPR029017" /db_xref="InterPro:IPR029065" /db_xref="InterPro:IPR036849" /db_xref="PDB:2GDQ" /db_xref="PDB:2GGE" /db_xref="SubtiList:BG13111" /db_xref="UniProtKB/Swiss-Prot:O06741" /translation="MKIVRIETFPLFHRLEKPYGDANGFKRYRTCYLIRIITESGIDG WGECVDWLPALHVGFTKRIIPFLLGKQAGSRLSLVRTIQKWHQRAASAVSMALTEIAA KAADCSVCELWGGRYREEIPVYASFQSYSDSPQWISRSVSNVEAQLKKGFEQIKVKIG GTSFKEDVRHINALQHTAGSSITMILDANQSYDAAAAFKWERYFSEWTNIGWLEEPLP FDQPQDYAMLRSRLSVPVAGGENMKGPAQYVPLLSQRCLDIIQPDVMHVNGIDEFRDC LQLARYFGVRASAHAYDGSLSRLYALFAQACLPPWSKMKNDHIEPIEWDVMENPFTDL VSLQPSKGMVHIPKGKGIGTEINMEIVNRYKWDGSAY*" /label="yitF CDS" gene complement(1124438..1125553) /gene="yitF" /locus_tag="BSU_10970" /old_locus_tag="BSU10970" /label="yitF gene" downshifts complement(1124467) /Source="Nicolas_upshifts" /id="D595" /incds=0 /nref=11 /ntot=42 /MaxReadThrough="1.81817" /MaxDrop="4.27426" /score="13.5713023" /energy="-14.5" /TU="NA" /idTUdmin="U883" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1125562..1126830) /gene="yitG" /locus_tag="BSU_10980" /old_locus_tag="BSU10980" /function="16.8: Protect" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106, 14762009, 15109717, 15849754, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388979.1" /db_xref="EnsemblGenomes-Gn:BSU10980" /db_xref="EnsemblGenomes-Tr:CAB12938" /db_xref="GOA:Q796Q1" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13112" /db_xref="UniProtKB/Swiss-Prot:Q796Q1" /translation="MESSKQNNGMTIVAIGSIPLILTLGNSMLIPILPKMKSELHLSQ FQVSLVITVFSLIAAFAIPIVGYLADRFSRKVIIIPCLILYGAGGLLAGFAAGFFDNA YPWVMAGRALQGIGAAGTGPIAMALTGDLFKGAQESKVLGLVEASNGMGKVLSPIIGS LIALLVWYGAFFAFPVFCIISIVLTWIFIKEKKKEKEPPPIGQYAKGLLSVFKHEGRW LFTAYLAGATCLFTLFGILFYLSDVLEKTYDTDGVKKGLILAIPLLVMCVTSYTTGSK IGQKQSLMKKLIVLGLAFMTVSYAALSFIENLVLFISVLVLSSIGSGLVLPCVNSFIT GAVGKERRGFVTSLYGSVRFLGVAIGPPIFGRLMQWSRPGMFLSIAGLTLVVGILVMM LIHVKQNNEETKEKEDPKMAGNRLQPAEER*" /label="yitG CDS" gene complement(1125562..1126830) /gene="yitG" /locus_tag="BSU_10980" /old_locus_tag="BSU10980" /label="yitG gene" promotor_-10 complement(1126856..1126867) /Source="Nicolas_upshift_promotors" /id="U883" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=932 /SigmaFactorBS="acaggtatcttctgttcggttttttgctgtctgatcgcTGAA TAAacgaagccatcagGGACATTCTAAGcagaagaaaaggagtgtgctctgagatgga a" /listShort="yitG, yitF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1126865) /Source="Nicolas_upshifts" /id="U883" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=932 /SigmaFactorBS="acaggtatcttctgttcggttttttgctgtctgatcgcTGAA TAAacgaagccatcagGGACATTCTAAGcagaagaaaaggagtgtgctctgagatgga a" /listShort="yitG, yitF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1126881..1126887) /Source="Nicolas_upshift_promotors" /id="U883" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=932 /SigmaFactorBS="acaggtatcttctgttcggttttttgctgtctgatcgcTGAA TAAacgaagccatcagGGACATTCTAAGcagaagaaaaggagtgtgctctgagatgga a" /listShort="yitG, yitF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1126942..1127790) /gene="yitH" /locus_tag="BSU_10990" /old_locus_tag="BSU10990" /EC_number="2.3.1.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_388980.1" /db_xref="EnsemblGenomes-Gn:BSU10990" /db_xref="EnsemblGenomes-Tr:CAB12939" /db_xref="GOA:O06743" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13113" /db_xref="UniProtKB/Swiss-Prot:O06743" /translation="MDVVDELIKLHEEHVSGLLRLCGQAGWPDYGEQELKLLVQQGRF FGYQNVSGDIISCIGLFLFGRLTSIGLVIVDKEYQRLGLGRRMVNACITQTDENTAIR LCATKEGLPLYEKAGFHTAGSVRKYSCHSFQPYTKKLDAELTSFREQDFHDLTAADLA AFGGDRSNLLQQLISASCECIIARNQDGQLIGYGLSVQTPANLKFGPIIAPSSDVAAQ IITRLAAGKQGPMRIDIPSEHTSLHDSLIEMGFHKDDEPPILFYQKKAPIQNGHLYAL ISQALG*" /label="yitH CDS" gene complement(1126942..1127790) /gene="yitH" /locus_tag="BSU_10990" /old_locus_tag="BSU10990" /label="yitH gene" downshifts complement(1126953) /Source="Nicolas_upshifts" /id="D596" /incds=0 /nref=34 /ntot=209 /MaxReadThrough="2.34135" /MaxDrop="3.51892" /score="14.8688564" /energy="-11.7" /TU="NA" /idTUdmin="U884" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1127795..1128244) /gene="yitI" /locus_tag="BSU_11000" /old_locus_tag="BSU11000" /EC_number="2.3.1.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_388981.2" /db_xref="EnsemblGenomes-Gn:BSU11000" /db_xref="EnsemblGenomes-Tr:CAB12940" /db_xref="GOA:O06744" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13114" /db_xref="UniProtKB/Swiss-Prot:O06744" /translation="MLEVKTISVEDTYEIRHRILRPHQSIEQCKYKEDHAEGSFHLGV FYDGTLISIASFSPQSQPLLTEASAYRLRGMATLEGYRDQKAGSTLIKHAEHKLAESG VQAVWCNARHHVKGYYAKLGWKELGEPFDIPGIGNHIVMYKTLRTSR*" /label="yitI CDS" gene complement(1127795..1128244) /gene="yitI" /locus_tag="BSU_11000" /old_locus_tag="BSU11000" /label="yitI gene" promotor_-10 complement(1128265..1128284) /Source="Nicolas_upshift_promotors" /id="U884" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.834165834165834" /psig="0.999000999001" /xcortree=2266 /SigmaFactorBS="cattaatttccaaaagactgcctgatcgaatcgggcagTCtt tttcaacgagattCGTGTTACGATATAGAAAAAcaatcatgaggaggaacattatgct c" /listShort="yitI, yitH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1128279) /Source="Nicolas_upshifts" /id="U884" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.834165834165834" /psig="0.999000999001" /xcortree=2266 /SigmaFactorBS="cattaatttccaaaagactgcctgatcgaatcgggcagTCtt tttcaacgagattCGTGTTACGATATAGAAAAAcaatcatgaggaggaacattatgct c" /listShort="yitI, yitH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1128300..1128301) /Source="Nicolas_upshift_promotors" /id="U884" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.834165834165834" /psig="0.999000999001" /xcortree=2266 /SigmaFactorBS="cattaatttccaaaagactgcctgatcgaatcgggcagTCtt tttcaacgagattCGTGTTACGATATAGAAAAAcaatcatgaggaggaacattatgct c" /listShort="yitI, yitH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1128334..1130172) /gene="samT" /locus_tag="BSU_11010" /old_locus_tag="BSU11010" /EC_number="1.5.1.20" /EC_number="2.1.1.10" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10094622, 17264075, 20421295, 20951706, 26233166; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional homocysteine S-methyltransferase using (R,S)AdoMet and methylenetetrahydrofolate reductase [NAD(P)H]" /protein_id="NP_388982.1" /db_xref="EnsemblGenomes-Gn:BSU11010" /db_xref="EnsemblGenomes-Tr:CAB12941" /db_xref="GOA:O06745" /db_xref="InterPro:IPR003171" /db_xref="InterPro:IPR003726" /db_xref="InterPro:IPR029041" /db_xref="InterPro:IPR036589" /db_xref="SubtiList:BG13115" /db_xref="UniProtKB/Swiss-Prot:O06745" /translation="MGLLEDLQRQVLIGDGAMGTLLYSYGIDRCFEELNISKPEEIQR IHKAYVEAGANIIQTNTYGANYIKLSRHGLEDDIKKMNQEAVKIARASAGDAYVLGTM GGIRTFNKNAYSLDEIKRSFREQLYLLLHEEPDGLLLETYYDLEEAREVLKIARKETD LPIMLNVSMHEQGVLQDGTPLSDALRSIADLGADIVGINCRLGPYHMIEALSEVPIFD DVFLSVYPNSSLPSLEEGRLVYETDDTYFQNSASEFRKQGARIIGGCCGTTPNHIRAM AEAVGGLAPITEKEVKTRAKEFISVHHERTEPGLDEIAAKKRSIIVELDPPKKLSFDK FLSAAAELKEAGIDALTLADNSLATPRISNVACGALVKQQLDMRSLVHITCRDRNIIG LQSHLMGLDTLGLNDVLAITGDPSKIGDFPGATSVYDLTSFDLIRLIKQFNEGLSLSG KPLGKKTNFSVAAAFNPNVRHLDKAVKRLEKKIDCGADYFVSQPVYSEQQLVDIHNET KHLKTPIYIGIMPLTSSRNAEFIHNEIPGIKLSDTIREKMAHAGEDKEKQKAEGLAIA RSLLDTACELFNGIYLITPFLRSDLTAELTSYIQQKDEQRQNIFLH*" /label="samT CDS" gene complement(1128334..1130172) /gene="samT" /locus_tag="BSU_11010" /old_locus_tag="BSU11010" /label="samT gene" downshifts complement(1128361) /Source="Nicolas_upshifts" /id="D597" /incds=0 /nref=14 /ntot=91 /MaxReadThrough="3.04289" /MaxDrop="4.13744" /score="12.9586126" /energy="-16.2" /TU="U885" /idTUdmin="U885" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" downshifts complement(1130254) /Source="Nicolas_upshifts" /id="D598" /incds=0 /nref=47 /ntot=128 /MaxReadThrough="8.00128" /MaxDrop="5.61487" /score="22.3754155" /energy="-7.3" /TU="U885,U887" /idTUdmin="U887" /TUdmin="-1079" /isTUend="FALSE" /label="downshifts" misc_RNA complement(1130262..1130379) /gene="mswK" /locus_tag="BSU_misc_RNA_12" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /function="16.3: Control" /label="mswK RNA" gene complement(1130262..1130379) /gene="mswK" /locus_tag="BSU_misc_RNA_12" /label="mswK gene" promotor_-10 complement(1130431..1130450) /Source="Nicolas_upshift_promotors" /id="U885" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig="0.999000999001" /xcortree=2886 /SigmaFactorBS="aatttataaatttcagataaattttctgattccTATTGATTa ttgtctttattttCGGTAAATTTGGAGAAAGGGaaaaacgccagatatcttttggcac t" /listShort="NA, yitJ" /listLong="yitI, yitH" /label="promotor_-10" upshifts complement(1130445) /Source="Nicolas_upshifts" /id="U885" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig="0.999000999001" /xcortree=2886 /SigmaFactorBS="aatttataaatttcagataaattttctgattccTATTGATTa ttgtctttattttCGGTAAATTTGGAGAAAGGGaaaaacgccagatatcttttggcac t" /listShort="NA, yitJ" /listLong="yitI, yitH" /label="upshifts" promotor_-35 complement(1130465..1130472) /Source="Nicolas_upshift_promotors" /id="U885" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig="0.999000999001" /xcortree=2886 /SigmaFactorBS="aatttataaatttcagataaattttctgattccTATTGATTa ttgtctttattttCGGTAAATTTGGAGAAAGGGaaaaacgccagatatcttttggcac t" /listShort="NA, yitJ" /listLong="yitI, yitH" /label="promotor_-35" CDS complement(1130486..1130977) /gene="yitK" /locus_tag="BSU_11020" /old_locus_tag="BSU11020" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12943362, 25329577; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA or cyclic d-GMP binding protein" /protein_id="NP_388983.1" /db_xref="EnsemblGenomes-Gn:BSU11020" /db_xref="EnsemblGenomes-Tr:CAB12942" /db_xref="InterPro:IPR007551" /db_xref="InterPro:IPR035570" /db_xref="InterPro:IPR035571" /db_xref="InterPro:IPR036183" /db_xref="SubtiList:BG13116" /db_xref="UniProtKB/Swiss-Prot:O06746" /translation="MAKESSFDIVSKVELPEVQNAIQIALKEISTRYDFKGSKSDISL DKEELVLVSDDEFKLSQLKDVLVSKLIKRNVPTKNIDYGKVENASGGTVRQRAKLVQG IDKDNAKKINTIIKNSGLKVKSQVQDDQVRVTGKNKDDLQQIISAVRGADLPIDVQFI NFR*" /label="yitK CDS" gene complement(1130486..1130977) /gene="yitK" /locus_tag="BSU_11020" /old_locus_tag="BSU11020" /label="yitK gene" promotor_-35 1130995..1130998 /Source="Nicolas_upshift_promotors" /id="U886" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.555444555444555" /psig="0.997002997002997" /xcortree=2548 /SigmaFactorBS="atcaaatgaactttcttttgccatatgaaaacctccataacA TTTaacttatgtgttgaTTATAGTAGAATAAAGAGAAacttccaacagaacaaagaat c" /listShort="yitL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1131001..1131020) /Source="Nicolas_upshift_promotors" /id="U887" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.851148851148851" /psig=1 /xcortree=3057 /SigmaFactorBS="acattttttccaatcatcacaaattgattctttgttcTGTTG GAAgtttctctttattcTACTATAATCAACACATAAGttaaatgttatggaggttttc a" /listShort="yitK, NA, yitJ" /listLong="yitI, yitH" /label="promotor_-10" promotor_-10 1131013..1131032 /Source="Nicolas_upshift_promotors" /id="U886" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.555444555444555" /psig="0.997002997002997" /xcortree=2548 /SigmaFactorBS="atcaaatgaactttcttttgccatatgaaaacctccataacA TTTaacttatgtgttgaTTATAGTAGAATAAAGAGAAacttccaacagaacaaagaat c" /listShort="yitL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1131014 /Source="Nicolas_upshifts" /id="U886" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.555444555444555" /psig="0.997002997002997" /xcortree=2548 /SigmaFactorBS="atcaaatgaactttcttttgccatatgaaaacctccataacA TTTaacttatgtgttgaTTATAGTAGAATAAAGAGAAacttccaacagaacaaagaat c" /listShort="yitL" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1131019) /Source="Nicolas_upshifts" /id="U887" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.851148851148851" /psig=1 /xcortree=3057 /SigmaFactorBS="acattttttccaatcatcacaaattgattctttgttcTGTTG GAAgtttctctttattcTACTATAATCAACACATAAGttaaatgttatggaggttttc a" /listShort="yitK, NA, yitJ" /listLong="yitI, yitH" /label="upshifts" promotor_-35 complement(1131035..1131042) /Source="Nicolas_upshift_promotors" /id="U887" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.851148851148851" /psig=1 /xcortree=3057 /SigmaFactorBS="acattttttccaatcatcacaaattgattctttgttcTGTTG GAAgtttctctttattcTACTATAATCAACACATAAGttaaatgttatggaggttttc a" /listShort="yitK, NA, yitJ" /listLong="yitI, yitH" /label="promotor_-35" CDS 1131076..1131972 /gene="yitL" /locus_tag="BSU_11030" /old_locus_tag="BSU11030" /function="9.4: RNA processing" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 20399190; Product type f : factor" /codon_start=1 /transl_table=11 /product="RNA-binding protein" /protein_id="NP_388984.1" /db_xref="EnsemblGenomes-Gn:BSU11030" /db_xref="EnsemblGenomes-Tr:CAB12943" /db_xref="GOA:O06747" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR014464" /db_xref="InterPro:IPR022967" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG13117" /db_xref="UniProtKB/Swiss-Prot:O06747" /translation="MLTKSAENKRNRKDDSMRPGQQLTLSIDHQTDFGYFLTDGEDTI LLHNSEMTEDIEDRDEVEVFIYVDQQERLAATMKIPIISADEYGWVEVVDKVEDMGVF VDVGLSKDALVATEHLPPYEDVWPQKGDKLYCMLKVTNRGRMFAKPAPEDIISELFTD ASEDLMNKELTGTVYRLIASGSFVITDDGIRCFIHPSERKEEPRLGSRVTGRVIQVKE DGSVNLSLLPRKQDAMSVDAECILTYMRMRNGAMPYSDKSQPDDIRERFNMSKAAFKR ALGHLMKNGKVYQENGWTYEKK*" /label="yitL CDS" gene 1131076..1131972 /gene="yitL" /locus_tag="BSU_11030" /old_locus_tag="BSU11030" /label="yitL gene" downshifts 1131959 /Source="Nicolas_upshifts" /id="D599" /incds=0 /nref=232 /ntot=261 /MaxReadThrough="1.78082" /MaxDrop="6.73614" /score="40.361011" /energy="-21.5" /TU="NA" /idTUdmin="U886" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1132025..1132609) /gene="yitM" /locus_tag="BSU_11040" /old_locus_tag="BSU11040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11557812" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388985.1" /db_xref="EnsemblGenomes-Gn:BSU11040" /db_xref="EnsemblGenomes-Tr:CAB12944" /db_xref="GOA:O06748" /db_xref="InterPro:IPR023888" /db_xref="SubtiList:BG13118" /db_xref="UniProtKB/Swiss-Prot:O06748" /translation="MKKAFLVFLSVVLVTTVFLVKQQESVAQAKQLEYSGEEIFKGFV FAQGEVGKQLPEVFNKAMTDKLNTKQAKAFANQVVADIKKEDADFFDNLKKAVYSKDA LKVDELLKKAGQIVEEKVEAAKEIAASKDDTSRVQAELVNTVDTANYFYYVSYVAAAG ALILIILAIDITPIAISDNVDREMAIRTLVDELN*" /label="yitM CDS" gene complement(1132025..1132609) /gene="yitM" /locus_tag="BSU_11040" /old_locus_tag="BSU11040" /label="yitM gene" downshifts complement(1132035) /Source="Nicolas_upshifts" /id="D600" /incds=0 /nref=68 /ntot=158 /MaxReadThrough="1.3386" /MaxDrop="7.40935" /score="10.143892" /energy="-21.5" /TU="NA" /idTUdmin="U888" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1132606..1133535) /gene="yitO" /locus_tag="BSU_11055" /old_locus_tag="BSU11055" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11557812, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein with HTTM domain" /protein_id="NP_388987.2" /db_xref="EnsemblGenomes-Gn:BSU11055" /db_xref="EnsemblGenomes-Tr:CAB12946" /db_xref="GOA:O06750" /db_xref="InterPro:IPR011020" /db_xref="InterPro:IPR023894" /db_xref="SubtiList:BG13120" /db_xref="UniProtKB/Swiss-Prot:O06750" /translation="MLENIKQTITRWDERNPWTNVYGLARSIIALSSLLTLLINHPSL IMKPASGISSYPACKMNLSLFCLGENNYMMLNLFRWVCIAILVLVVIGWRPRITGVLH WYVSYSLQSSLIVIDGGEQAAAVMTFLLLPITLTDPRKWHWSTRPIEGKRTLGKITAF ISYFVIRIQVAVLYFHSTVAKLSQQEWVDGTAVYYFAQEKTIGFNGFFQALTKPIVTS PFVVIPTWGTLLVQIVIFAALFAPKKHWRLILIIAVFMHEIFAVMLGLISFSIIMAGI LILYLTPIDSTIQFTYIRRLLWNKKHKKGEVSV*" /label="yitO CDS" gene complement(1132606..1133535) /gene="yitO" /locus_tag="BSU_11055" /old_locus_tag="BSU11055" /label="yitO gene" upshifts complement(1132693) /Source="Nicolas_upshifts" /id="U888" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.232767232767233" /psig="0.63936063936064" /xcortree=2974 /SigmaFactorBS="agtcatgctgggcctcatcagtttttcgattatcatggccgg cattttgatattgtatctcaCtcctatcgattccacgattcaatttacatatattcgc a" /listShort="yitM" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1133520..1134056) /gene="yitP" /locus_tag="BSU_11070" /old_locus_tag="BSU11070" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 6289325, 11557812" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388988.1" /db_xref="EnsemblGenomes-Gn:BSU11070" /db_xref="EnsemblGenomes-Tr:CAB12947" /db_xref="GOA:O06751" /db_xref="InterPro:IPR023902" /db_xref="SubtiList:BG13121" /db_xref="UniProtKB/Swiss-Prot:O06751" /translation="MQKSISFFVIFSILWGSLFLFSIIGSLGTTPIPLTKDSKFLMSS ILPQGWGFFSKNPRDTAIGLYEAENASAKVRWPNMRADNLFGLYRYGRSQGVEMGVIY SQVGKEQWTACKEKDLGACKSKAKTVQLKTPAPRPLLCGSYYLTKEDIVPWSYSKYTP SSYQVKSIVKVVISCSKT*" /label="yitP CDS" gene complement(1133520..1134056) /gene="yitP" /locus_tag="BSU_11070" /old_locus_tag="BSU11070" /label="yitP gene" promotor_-10 complement(1134092..1134111) /Source="Nicolas_upshift_promotors" /id="U889" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.71028971028971" /psig="0.988011988011988" /xcortree=2975 /SigmaFactorBS="ccttttaacaaaaatggaatttctcatactttttaacCTTTt tattacataaatgTTTTTATATTATGAAAAGTGtaaaaacgattcttcaggttaaaag g" /listShort="yitP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1134106) /Source="Nicolas_upshifts" /id="U889" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.71028971028971" /psig="0.988011988011988" /xcortree=2975 /SigmaFactorBS="ccttttaacaaaaatggaatttctcatactttttaacCTTTt tattacataaatgTTTTTATATTATGAAAAGTGtaaaaacgattcttcaggttaaaag g" /listShort="yitP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1134126..1134129) /Source="Nicolas_upshift_promotors" /id="U889" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.71028971028971" /psig="0.988011988011988" /xcortree=2975 /SigmaFactorBS="ccttttaacaaaaatggaatttctcatactttttaacCTTTt tattacataaatgTTTTTATATTATGAAAAGTGtaaaaacgattcttcaggttaaaag g" /listShort="yitP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1134197..1134204 /Source="Nicolas_upshift_promotors" /id="U890" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.767232767232767" /psig=1 /xcortree=3150 /SigmaFactorBS="aaaggaaaaacaggacattttacactgctatatgtGATTGAT AtatagtgtttttttCGATATATTTAAACCATGAAaacgaatcaagttaatgaccgct g" /listShort="yizB, yitQ, yitR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1134219..1134238 /Source="Nicolas_upshift_promotors" /id="U890" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.767232767232767" /psig=1 /xcortree=3150 /SigmaFactorBS="aaaggaaaaacaggacattttacactgctatatgtGATTGAT AtatagtgtttttttCGATATATTTAAACCATGAAaacgaatcaagttaatgaccgct g" /listShort="yizB, yitQ, yitR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1134222 /Source="Nicolas_upshifts" /id="U890" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.767232767232767" /psig=1 /xcortree=3150 /SigmaFactorBS="aaaggaaaaacaggacattttacactgctatatgtGATTGAT AtatagtgtttttttCGATATATTTAAACCATGAAaacgaatcaagttaatgaccgct g" /listShort="yizB, yitQ, yitR" /GFF_Attribute="listLong" /label="upshifts" CDS 1134234..1134581 /gene="yizB" /locus_tag="BSU_11079" /old_locus_tag="BSU11079" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23504016; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="YP_003097701.1" /db_xref="EnsemblGenomes-Gn:BSU11079" /db_xref="EnsemblGenomes-Tr:CAX52589" /db_xref="GOA:C0H3Y4" /db_xref="InterPro:IPR005149" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="UniProtKB/Swiss-Prot:C0H3Y4" /translation="MKTNQVNDRWIVQFRKGIFELAILSLLRSKPMYGYELTSSLKTT SALAISEGAIYPILKRMTEKGWIEFFWEDSLDGPKRKYYKMTQKGEEMLKERLEKYLE THQALLSLSGDLL*" /label="yizB CDS" gene 1134234..1134581 /gene="yizB" /locus_tag="BSU_11079" /old_locus_tag="BSU11079" /label="yizB gene" CDS 1134578..1135165 /gene="yitQ" /locus_tag="BSU_11080" /old_locus_tag="BSU11080" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 23504016" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388989.2" /db_xref="EnsemblGenomes-Gn:BSU11080" /db_xref="EnsemblGenomes-Tr:CAB12948" /db_xref="GOA:O06752" /db_xref="SubtiList:BG13122" /db_xref="UniProtKB/Swiss-Prot:O06752" /translation="MNGQLIIDRYMEELNAELANMPDVERENAIDELKGHITAFVQDR IKAGLSEEELQEAVESEFSHPKELAELMMGDGGETKRRRSLLGKSWISVLLIVTIIAL PLLPSDFRHLPLAVYLMVLAGYVWKRKKLVMFAGVRKNKMRSQKEIVKISRVGAVYLL FLAVVLLLSPFLNALVVLLLIAVSCAAFFLFLNIK*" /label="yitQ CDS" gene 1134578..1135165 /gene="yitQ" /locus_tag="BSU_11080" /old_locus_tag="BSU11080" /label="yitQ gene" CDS 1135185..1135478 /gene="yitR" /locus_tag="BSU_11090" /old_locus_tag="BSU11090" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388990.1" /db_xref="EnsemblGenomes-Gn:BSU11090" /db_xref="EnsemblGenomes-Tr:CAB12949" /db_xref="GOA:O06753" /db_xref="InterPro:IPR017259" /db_xref="SubtiList:BG13123" /db_xref="UniProtKB/Swiss-Prot:O06753" /translation="MEISINYLLIVIALLFFVVAYFVGIKKQTWMLAGFNEARIRDKD RLARIAGYFFLNSGLFILLNSFISFQGQEQLIPPLILAYGAGVIIYVNKKLVE*" /label="yitR CDS" gene 1135185..1135478 /gene="yitR" /locus_tag="BSU_11090" /old_locus_tag="BSU11090" /label="yitR gene" downshifts 1135458 /Source="Nicolas_upshifts" /id="D601" /incds=0 /nref=119 /ntot=240 /MaxReadThrough="1.96008" /MaxDrop="5.72545" /score="2.11183863" /energy="-12.6" /TU="NA" /idTUdmin="U890" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 1135502 /Source="Nicolas_upshifts" /id="D602" /incds=0 /nref=1 /ntot=15 /MaxReadThrough="0.34732" /MaxDrop="3.0285" /score="2.11183863" /energy="-12.6" /TU="NA" /idTUdmin="U890" /TUdmin=44 /isTUend="FALSE" /label="downshifts" CDS 1135614..1137230 /gene="nprB" /locus_tag="BSU_11100" /old_locus_tag="BSU11100" /EC_number="3.4.24.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:1917867, 16672610" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1917867, 16672610; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="extracellular neutral protease B" /protein_id="NP_388991.1" /db_xref="EnsemblGenomes-Gn:BSU11100" /db_xref="EnsemblGenomes-Tr:CAB12950" /db_xref="GOA:P39899" /db_xref="InterPro:IPR001570" /db_xref="InterPro:IPR011096" /db_xref="InterPro:IPR013856" /db_xref="InterPro:IPR023612" /db_xref="InterPro:IPR025711" /db_xref="SubtiList:BG10691" /db_xref="UniProtKB/Swiss-Prot:P39899" /translation="MRNLTKTSLLLAGLCTAAQMVFVTHASAEESIEYDHTYQTPSYI IEKSPQKPVQNTTQKESLFSYLDKHQTQFKLKGNANSHFRVSKTIKDPKTKQTFFKLT EVYKGIPIYGFEQAVAMKENKQVKSFFGKVHPQIKDVSVTPSISEKKAIHTARRELEA SIGKIEYLDGEPKGELYIYPHDGEYDLAYLVRLSTSEPEPGYWHYFIDAKNGKVIESF NAIHEAAGTGIGVSGDEKSFDVTEQNGRFYLADETRGKGINTFDAKNLNETLFTLLSQ LIGYTGKEIVSGTSVFNEPAAVDAHANAQAVYDYYSKTFGRDSFDQNGARITSTVHVG KQWNNAAWNGVQMVYGDGDGSKFKPLSGSLDIVAHEITHAVTQYSAGLLYQGEPGALN ESISDIMGAMADRDDWEIGEDVYTPGIAGDSLRSLEDPSKQGNPDHYSNRYTGTEDYG GVHINSSIHNKAAYLLAEGGVHHGVQVEGIGREASEQIYYRALTYYVTASTDFSMMKQ AAIEAANDLYGEGSKQSASVEKAYEAVGIL*" /label="nprB CDS" gene 1135614..1137230 /gene="nprB" /locus_tag="BSU_11100" /old_locus_tag="BSU11100" /label="nprB gene" downshifts 1137218 /Source="Nicolas_upshifts" /id="D603" /incds=0 /nref=2 /ntot=55 /MaxReadThrough="0.278770000000001" /MaxDrop="3.08544" /score="2.81939887" /energy="-8.6" /TU="NA" /idTUdmin="U890" /TUdmin=1760 /isTUend="FALSE" /label="downshifts" CDS complement(1137277..1138128) /gene="fakBB" /locus_tag="BSU_11110" /old_locus_tag="BSU11110" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 25002480, 26774272, 27435445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fatty acid kinase fatty acid binding subunit B" /protein_id="NP_388992.1" /db_xref="EnsemblGenomes-Gn:BSU11110" /db_xref="EnsemblGenomes-Tr:CAB12951" /db_xref="GOA:P70945" /db_xref="InterPro:IPR003797" /db_xref="SubtiList:BG12244" /db_xref="UniProtKB/Swiss-Prot:P70945" /translation="MTVHLIADSATDLPRSYFEEKGIGFIPLRVSLGDKEFEDAVTIH ADQIFEAMQNGETPKTSQASPQTIKNVFLQYAETGDPALYIAFSSGLSGTYQTAVMIA NEVKEEFPDFDLRVIDSKCASLGYGLAVRHAADLCINGNTIQEIETSVKNFCSQLEHI FTVDDLTYLARGGRISKTSAFVGGLLNIKPLLQMEDGKLVPLEKIRGQKKLFKRIIEL MKERGDDWSNQTVGISYAANKEKATDMKHLIEEAFKPKEIIMHPISSAIGSHAGPGTL AIFFLRK*" /label="fakBB CDS" gene complement(1137277..1138128) /gene="fakBB" /locus_tag="BSU_11110" /old_locus_tag="BSU11110" /label="fakBB gene" downshifts complement(1137294) /Source="Nicolas_upshifts" /id="D604" /incds=0 /nref=209 /ntot=263 /MaxReadThrough="0.727580000000001" /MaxDrop="6.86927" /score="-1.24586831" /energy="-7.7" /TU="NA" /idTUdmin="U892" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1137675..1137682 /Source="Nicolas_upshift_promotors" /id="U891" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.78021978021978" /psig="0.996003996003996" /xcortree=2481 /SigmaFactorBS="gtaaaaatgtgttcaagctggctgcaaaagtTCTTTACAgac gtttcaatttcTTGTATTGTATTCCCGTTGAtacagagatcggcagcatgccggacag c" /listShort="S395, yitT, S396, ipi" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1137697..1137716 /Source="Nicolas_upshift_promotors" /id="U891" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.78021978021978" /psig="0.996003996003996" /xcortree=2481 /SigmaFactorBS="gtaaaaatgtgttcaagctggctgcaaaagtTCTTTACAgac gtttcaatttcTTGTATTGTATTCCCGTTGAtacagagatcggcagcatgccggacag c" /listShort="S395, yitT, S396, ipi" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1137702..1138227 /Source="Nicolas_S_feature" /locus_tag="new_1188125_1188650" /HighExp="G180, Paraq, G135, G150, Oxctl, C30, H2O2, LBGstat, LBGexp, Lbexp" /AntisenseName="yitS" /AntisenseCor="-0.45830528686941202" /AntisenseRegPval="-14.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S395" upshifts 1137704 /Source="Nicolas_upshifts" /id="U891" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.78021978021978" /psig="0.996003996003996" /xcortree=2481 /SigmaFactorBS="gtaaaaatgtgttcaagctggctgcaaaagtTCTTTACAgac gtttcaatttcTTGTATTGTATTCCCGTTGAtacagagatcggcagcatgccggacag c" /listShort="S395, yitT, S396, ipi" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1138169..1138188) /Source="Nicolas_upshift_promotors" /id="U892" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.558441558441558" /psig="0.841158841158841" /xcortree=594 /SigmaFactorBS="gctctttcttctttattatgttttcccttaaaacaaatattt gaAcacgattttggcaaattaaTATGATATAGTTGGCTTAACtctcatgataacgagc g" /listShort="yitS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1138192) /Source="Nicolas_upshifts" /id="U892" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.558441558441558" /psig="0.841158841158841" /xcortree=594 /SigmaFactorBS="gctctttcttctttattatgttttcccttaaaacaaatattt gaAcacgattttggcaaattaaTATGATATAGTTGGCTTAACtctcatgataacgagc g" /listShort="yitS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1138206..1138211 /Source="Nicolas_upshift_promotors" /id="U893" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=738 /SigmaFactorBS="gttaagccaactatatcatattaatttgccaaaatcgTGTTC AaatatttgttttaaGGGAAAACATAATAAAGAAgaaagagcggaggaacatgccatg g" /listShort="yitT, S396, ipi" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1138226..1138244 /Source="Nicolas_upshift_promotors" /id="U893" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=738 /SigmaFactorBS="gttaagccaactatatcatattaatttgccaaaatcgTGTTC AaatatttgttttaaGGGAAAACATAATAAAGAAgaaagagcggaggaacatgccatg g" /listShort="yitT, S396, ipi" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1138229 /Source="Nicolas_upshifts" /id="U893" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=738 /SigmaFactorBS="gttaagccaactatatcatattaatttgccaaaatcgTGTTC AaatatttgttttaaGGGAAAACATAATAAAGAAgaaagagcggaggaacatgccatg g" /listShort="yitT, S396, ipi" /GFF_Attribute="listLong" /label="upshifts" CDS 1138266..1139108 /gene="yitT" /locus_tag="BSU_11120" /old_locus_tag="BSU11120" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 23419162, 23824080; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_388993.1" /db_xref="EnsemblGenomes-Gn:BSU11120" /db_xref="EnsemblGenomes-Tr:CAB12952" /db_xref="GOA:P39803" /db_xref="InterPro:IPR003740" /db_xref="InterPro:IPR019264" /db_xref="SubtiList:BG10850" /db_xref="UniProtKB/Swiss-Prot:P39803" /translation="MVLDQTKKLLIVIIGALLNAAGLNLFLIPADVYASGFTGVAQLL SSVVDQYAPFYISTGTLLFLLNIPVGILGWLKVGKSFTVYSILSVALTTLFMGILPET SLSHDILLNAVFGGVISAVGIGLTLKYGASTGGLDIVAMVLAKWKDKPVGTYFFILNG IIILTAGLLQGWEKALYTLVTLYVTTRVIDAIHTRHMKLTAMIVTKKADEIKEAIYGK MVRGITTVPAKGAFTNEQKEMMIIVITRYELYDLEKIVKEVDPKAFTNIVQTTGIFGF FRKD*" /label="yitT CDS" gene 1138266..1139108 /gene="yitT" /locus_tag="BSU_11120" /old_locus_tag="BSU11120" /label="yitT gene" promotor_-35 1138761..1138769 /Source="Nicolas_upshift_promotors" /id="U894" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.968031968031968" /psig="0.968031968031968" /xcortree=467 /SigmaFactorBS="gcacgtatttcttcattctgaacgggattatcatcttgacgG CAGGATTAttgcaaggttGGGAGAAAGCATTATATACcctggttacactatatgtgac a" /listShort="S396, ipi" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1138780..1138798 /Source="Nicolas_upshift_promotors" /id="U894" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.968031968031968" /psig="0.968031968031968" /xcortree=467 /SigmaFactorBS="gcacgtatttcttcattctgaacgggattatcatcttgacgG CAGGATTAttgcaaggttGGGAGAAAGCATTATATACcctggttacactatatgtgac a" /listShort="S396, ipi" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1138780 /Source="Nicolas_upshifts" /id="U894" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.968031968031968" /psig="0.968031968031968" /xcortree=467 /SigmaFactorBS="gcacgtatttcttcattctgaacgggattatcatcttgacgG CAGGATTAttgcaaggttGGGAGAAAGCATTATATACcctggttacactatatgtgac a" /listShort="S396, ipi" /GFF_Attribute="listLong" /label="upshifts" S_feature 1139109..1139222 /Source="Nicolas_S_feature" /locus_tag="new_1189532_1189645" /HighExp="Etha, S8, Sw, M9-stat, S7, BC, Gly, S6, Salt, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH, SigB, SigA" /TUshortPSig="0.968, 0.998, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S396" CDS 1139223..1139582 /gene="ipi" /locus_tag="BSU_11130" /old_locus_tag="BSU11130" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8226659, 24555072" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8226659, 24555072; Product type f: factor" /codon_start=1 /transl_table=11 /product="intracellular proteinase inhibitor BsuPI" /protein_id="NP_388994.1" /db_xref="EnsemblGenomes-Gn:BSU11130" /db_xref="EnsemblGenomes-Tr:CAB12953" /db_xref="GOA:P39804" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR020481" /db_xref="PDB:3ISY" /db_xref="SubtiList:BG10852" /db_xref="UniProtKB/Swiss-Prot:P39804" /translation="MENQEVVLSIDAIQEPEQIKFNMSLKNQSERAIEFQFSTGQKFE LVVYDSEHKERYRYSKEKMFTQAFQNLTLESGETYDFSDVWKEVPEPGTYEVKVTFKG RAENLKQVQAVQQFEVK*" /label="ipi CDS" gene 1139223..1139582 /gene="ipi" /locus_tag="BSU_11130" /old_locus_tag="BSU11130" /label="ipi gene" downshifts 1139571 /Source="Nicolas_upshifts" /id="D605" /incds=0 /nref=34 /ntot=224 /MaxReadThrough="1.36729" /MaxDrop="5.6855" /score="43.7575824" /energy="-15.6" /TU="NA" /idTUdmin="U893" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1139613..1139810) /gene="yizC" /locus_tag="BSU_11139" /old_locus_tag="BSU11139" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; genus orphan" /protein_id="YP_003097702.1" /db_xref="EnsemblGenomes-Gn:BSU11139" /db_xref="EnsemblGenomes-Tr:CAX52590" /db_xref="InterPro:IPR024217" /db_xref="UniProtKB/Swiss-Prot:C0H3Y5" /translation="MRNELFQQAKSFVQQAVMVTNGFEEGDQEQAILRAKNAVSSAYA NSTDAERQQLHQFQNQLDKLQ*" /label="yizC CDS" gene complement(1139613..1139810) /gene="yizC" /locus_tag="BSU_11139" /old_locus_tag="BSU11139" /label="yizC gene" downshifts complement(1139626) /Source="Nicolas_upshifts" /id="D606" /incds=0 /nref=150 /ntot=257 /MaxReadThrough="1.42333" /MaxDrop="8.284" /score="2.35557074" /energy="-17.3" /TU="NA" /idTUdmin="U895" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1139811..1140007) /Source="Nicolas_S_feature" /locus_tag="new_1190234_1190430_c" /HighExp="S8, S6, S5, S7, nit, ferm, BT, G/S, Pyr, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99834599999999996" /TUshortSig="SigGF, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S397" upshifts complement(1140007) /Source="Nicolas_upshifts" /id="U895" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=848 /SigmaFactorBS="aagaaggtccgtattaatttttcccaCTCATAAaccttactt tacccCACCATACTATTgaagacgactcatctcgtcaaagtatggaagggggcagtct c" /listShort="S397, yizC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1140009..1140020) /Source="Nicolas_upshift_promotors" /id="U895" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=848 /SigmaFactorBS="aagaaggtccgtattaatttttcccaCTCATAAaccttactt tacccCACCATACTATTgaagacgactcatctcgtcaaagtatggaagggggcagtct c" /listShort="S397, yizC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1140035..1140041) /Source="Nicolas_upshift_promotors" /id="U895" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=848 /SigmaFactorBS="aagaaggtccgtattaatttttcccaCTCATAAaccttactt tacccCACCATACTATTgaagacgactcatctcgtcaaagtatggaagggggcagtct c" /listShort="S397, yizC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1140067..1140879) /gene="ribZC" /locus_tag="BSU_11140" /old_locus_tag="BSU11140" /function="4.9: Riboflavin, FMN, and FAD" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 25012491, 26316208; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-amino-6-ribitylamino-2,4(1H, 3H)-pyrimidinedione 5'-phosphate phosphatase (promiscuous)" /protein_id="NP_388995.1" /db_xref="EnsemblGenomes-Gn:BSU11140" /db_xref="EnsemblGenomes-Tr:CAB12954" /db_xref="GOA:P70947" /db_xref="InterPro:IPR000150" /db_xref="InterPro:IPR006379" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG12245" /db_xref="UniProtKB/Swiss-Prot:P70947" /translation="METKPYLIALDLDGTLLKDDKTISENTLHTIQRLKDDGHYVCIS TGRPYRSSSMYYQQMELTTPIVNFNGAFVHHPQDDSWGRYHTSLPLDVVKQLVDISES YNVHNVLAEVIDDVYFHYHDEHLIDAFNMNTTNVTVGDLRENLGEDVTSVLIHAKEED VPAIRSYLSDVHAEVIDHRRWAAPWHVIEIIKSGMNKAVGLQKISDYYGVPRERIIAF GDEDNDLEMLEFAGCGVAMGNGIDAVKQIANRTTATNEEDGVARFLKEYFSL*" /label="ribZC CDS" gene complement(1140067..1140879) /gene="ribZC" /locus_tag="BSU_11140" /old_locus_tag="BSU11140" /label="ribZC gene" promotor_-10 complement(1140917..1140936) /Source="Nicolas_upshift_promotors" /id="U896" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.483516483516484" /psig=1 /xcortree=2075 /SigmaFactorBS="tgtgcccctccttaggataaccataatcataagtgtaacaTG TAGACAataaagatggtaaAAAGCTACACTGTAAGTAAGgcaaaacaagcaaaatcta a" /listShort="yitU, S397, yizC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 1140937..1140944 /Source="Nicolas_upshift_promotors" /id="U897" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1854 /SigmaFactorBS="tagattttgcttgttttgccttacttacagtgtagctttTTA CCATCtttattgtctaCATGTTACACTTATGATTATggttatcctaaggaggggcaca t" /listShort="yitV, yitW, S398, yitY, yitZ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1140937) /Source="Nicolas_upshifts" /id="U896" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.483516483516484" /psig=1 /xcortree=2075 /SigmaFactorBS="tgtgcccctccttaggataaccataatcataagtgtaacaTG TAGACAataaagatggtaaAAAGCTACACTGTAAGTAAGgcaaaacaagcaaaatcta a" /listShort="yitU, S397, yizC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1140950..1140957) /Source="Nicolas_upshift_promotors" /id="U896" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.483516483516484" /psig=1 /xcortree=2075 /SigmaFactorBS="tgtgcccctccttaggataaccataatcataagtgtaacaTG TAGACAataaagatggtaaAAAGCTACACTGTAAGTAAGgcaaaacaagcaaaatcta a" /listShort="yitU, S397, yizC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1140956..1140975 /Source="Nicolas_upshift_promotors" /id="U897" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1854 /SigmaFactorBS="tagattttgcttgttttgccttacttacagtgtagctttTTA CCATCtttattgtctaCATGTTACACTTATGATTATggttatcctaaggaggggcaca t" /listShort="yitV, yitW, S398, yitY, yitZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1140958 /Source="Nicolas_upshifts" /id="U897" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1854 /SigmaFactorBS="tagattttgcttgttttgccttacttacagtgtagctttTTA CCATCtttattgtctaCATGTTACACTTATGATTATggttatcctaaggaggggcaca t" /listShort="yitV, yitW, S398, yitY, yitZ" /GFF_Attribute="listLong" /label="upshifts" CDS 1141000..1141767 /gene="yitV" /locus_tag="BSU_11150" /old_locus_tag="BSU11150" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 28293230; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative carboxylesterase" /protein_id="NP_388996.1" /db_xref="EnsemblGenomes-Gn:BSU11150" /db_xref="EnsemblGenomes-Tr:CAB12955" /db_xref="GOA:P70948" /db_xref="InterPro:IPR001375" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12246" /db_xref="UniProtKB/Swiss-Prot:P70948" /translation="MIQIENQTVSGIPFLHIVKEENRHRAVPLVIFIHGFTSAKEHNL HIAYLLAEKGFRAVLPEALHHGERGEEMAVEELAGHFWDIVLNEIEEIGVLKNHFEKE GLIDGGRIGLAGTSMGGITTLGALTAYDWIKAGVSLMGSPNYVELFQQQIDHIQSQGI EIDVPEEKVQQLMKRLELRDLSLQPEKLQQRPLLFWHGAKDKVVPYAPTRKFYDTIKS HYSEQPERLQFIGDENADHKVPRAAVLKTIEWFETYL*" /label="yitV CDS" gene 1141000..1141767 /gene="yitV" /locus_tag="BSU_11150" /old_locus_tag="BSU11150" /label="yitV gene" promotor_-35 1141776..1141782 /Source="Nicolas_upshift_promotors" /id="U898" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.723276723276723" /psig=1 /xcortree=2071 /SigmaFactorBS="aaacgattgaatggtttgaaacgtacttataaagcactaaGT TATTAacaagagctgaattTACGTTATACTGTAGAAAAAaggagtgagggaacgtgga a" /listShort="yitW, S398, yitY, yitZ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1141796 /Source="Nicolas_upshifts" /id="U898" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.723276723276723" /psig=1 /xcortree=2071 /SigmaFactorBS="aaacgattgaatggtttgaaacgtacttataaagcactaaGT TATTAacaagagctgaattTACGTTATACTGTAGAAAAAaggagtgagggaacgtgga a" /listShort="yitW, S398, yitY, yitZ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1141797..1141816 /Source="Nicolas_upshift_promotors" /id="U898" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.723276723276723" /psig=1 /xcortree=2071 /SigmaFactorBS="aaacgattgaatggtttgaaacgtacttataaagcactaaGT TATTAacaagagctgaattTACGTTATACTGTAGAAAAAaggagtgagggaacgtgga a" /listShort="yitW, S398, yitY, yitZ" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1141831..1142139 /gene="yitW" /locus_tag="BSU_11160" /old_locus_tag="BSU11160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9209063; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative protein involved in Fe-S cluster assembly, PaaD-like" /protein_id="NP_388997.1" /db_xref="EnsemblGenomes-Gn:BSU11160" /db_xref="EnsemblGenomes-Tr:CAB12956" /db_xref="InterPro:IPR002744" /db_xref="InterPro:IPR034904" /db_xref="SubtiList:BG12247" /db_xref="UniProtKB/Swiss-Prot:P70949" /translation="MEEALKENIMGALEQVVDPELGVDIVNLGLVYDVDMDEDGLTHI TMTLTSMGCPLAPIIVDEVKKALADLPEVKDTEVHIVWNPPWTRDKMSRYAKIALGIQ *" /label="yitW CDS" gene 1141831..1142139 /gene="yitW" /locus_tag="BSU_11160" /old_locus_tag="BSU11160" /label="yitW gene" downshifts 1142124 /Source="Nicolas_upshifts" /id="D607" /incds=0 /nref=3 /ntot=55 /MaxReadThrough="5.65659" /MaxDrop="4.5598" /score="14.9971829" /energy="-14.7" /TU="U897,U898" /idTUdmin="U897" /TUdmin="-2244" /isTUend="FALSE" /label="downshifts" S_feature 1142169..1142434 /Source="Nicolas_S_feature" /locus_tag="new_1192592_1192857" /HighExp="Etha, dia15, dia5, H2O2, LoTm, Salt, S6, Diami, S8, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba=1 /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S398" CDS 1142435..1143865 /gene="yitY" /locus_tag="BSU_11170" /old_locus_tag="BSU11170" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12682299, 16956367; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative FMN/FAD-binding oxidoreductase" /protein_id="NP_388999.3" /db_xref="EnsemblGenomes-Gn:BSU11170" /db_xref="EnsemblGenomes-Tr:CAB12958" /db_xref="GOA:Q796P5" /db_xref="InterPro:IPR006094" /db_xref="InterPro:IPR016164" /db_xref="InterPro:IPR016166" /db_xref="InterPro:IPR016167" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG12249" /db_xref="UniProtKB/Swiss-Prot:Q796P5" /translation="MKKKLLAFALCTGAYAALFAYSVNSEQKTATSEMTDVSRLMPVK IKQTVKGQEEEMLIDTVKEANRKNIKISIAGAQHSMGGHTYYEDGIVLDMTGYNKILS LDQEKKTIRVQSGATWNDIQKYVNPYGLAVKVMQSQNIFTIGGSLSANAHGRDIRYGS LIDTVKSFRLLKADGMIITVTPKDDLFTAVIGGYGLFGVILDVTLELTDDELYVMKTE KMNYSTYSDYFSKHVKGNPDVRMHLARISTAKKGFLKDMYVTNYVLANHQDQLSSYSE LKEDEYTGATKFALGLSRRYEWGRNWLWDTQQSYFLSQNGTEISRNNVMRSESKFLEY ENNDNTDVLQEYFVPVKEYGSYIDDLRQTLSDEDLNLLNITIRYVQKNEKADLSYAKD DMFSLVLLINEGFSKEDQADTARIIRRMTDVAIKHGGSYYLPYMTYQTKAQMRQAYPK SEAFFQKKRTYDPDERFMNYFYQRYK*" /label="yitY CDS" gene 1142435..1143865 /gene="yitY" /locus_tag="BSU_11170" /old_locus_tag="BSU11170" /label="yitY gene" CDS 1143910..1144404 /gene="yitZ" /locus_tag="BSU_11180" /old_locus_tag="BSU11180" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative transport protein" /protein_id="NP_389000.1" /db_xref="EnsemblGenomes-Gn:BSU11180" /db_xref="EnsemblGenomes-Tr:CAB12959" /db_xref="GOA:P70952" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12250" /db_xref="UniProtKB/Swiss-Prot:P70952" /translation="MFFASSLIFPFYILFVKNIGSSYTQFGFSYGLFGLSGALIYPLL GRLSERFDSRYFLLLNSWGMAVLLLYVPHIGSVVQVYIVQVLLGLFGAMQKHGEKVLI ANFTDSGERGKKIGNYHFWTAVFSAAAIMLGGFLADFFTVQMIFYASSILYFLSGLMM MKTG*" /label="yitZ CDS" gene 1143910..1144404 /gene="yitZ" /locus_tag="BSU_11180" /old_locus_tag="BSU11180" /label="yitZ gene" downshifts 1144368 /Source="Nicolas_upshifts" /id="D608" /incds=0 /nref=49 /ntot=208 /MaxReadThrough="1.74762" /MaxDrop="4.22077" /score="34.1294744" /energy="-13.2" /TU="NA" /idTUdmin="U897" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1144542..1144549 /Source="Nicolas_upshift_promotors" /id="U899" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig="0.999000999001" /xcortree=2913 /SigmaFactorBS="gcggaattcccattgaacagaaaatttataaatgaataaaaa tattaaatatacGATTGAATtaatttttattcaTGTTATAATGTTAAATAATTtcaca a" /listShort="argC, argJ, argB, argD, carA, carB, argF, yjzC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1144548 /Source="Nicolas_upshifts" /id="U899" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig="0.999000999001" /xcortree=2913 /SigmaFactorBS="gcggaattcccattgaacagaaaatttataaatgaataaaaa tattaaatatacGATTGAATtaatttttattcaTGTTATAATGTTAAATAATTtcaca a" /listShort="argC, argJ, argB, argD, carA, carB, argF, yjzC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1144563..1144582 /Source="Nicolas_upshift_promotors" /id="U899" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig="0.999000999001" /xcortree=2913 /SigmaFactorBS="gcggaattcccattgaacagaaaatttataaatgaataaaaa tattaaatatacGATTGAATtaatttttattcaTGTTATAATGTTAAATAATTtcaca a" /listShort="argC, argJ, argB, argD, carA, carB, argF, yjzC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1144611..1145648 /gene="argC" /locus_tag="BSU_11190" /old_locus_tag="BSU11190" /EC_number="1.2.1.38" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2117746, 3005232, 3106155, 6096674, 6096675, 8025667, 18455186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2117746, 3005232, 3106155, 6096674, 6096675, 8025667, 18455186; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylglutamate gamma-semialdehyde dehydrogenase" /protein_id="NP_389001.2" /db_xref="EnsemblGenomes-Gn:BSU11190" /db_xref="EnsemblGenomes-Tr:CAB12960" /db_xref="GOA:P23715" /db_xref="InterPro:IPR000534" /db_xref="InterPro:IPR000706" /db_xref="InterPro:IPR012280" /db_xref="InterPro:IPR023013" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10191" /db_xref="UniProtKB/Swiss-Prot:P23715" /translation="MKIGIVGATGYGGTELVRILSHHPHAEECILYSSSGEGNVYSEG YPHLTGLADQQLKPIDMNTIKHEIDIMFLAAPPGVSSELTPKLADAGITVIDLSGDLR IKEPAEYEKWYKRTAAPKAVIQEAVYGLAELNQLQIQQAKLIANPGCFPTAVLLGLAP LAQKKLLDESFVIVDAKTGVSGAGRKASMGTHFSELNDNFKIYKVNEHQHTPEIEQAL NEWQPGLGPITFSAHLVPMTRGIMATMYTRLTCDLTADDLHDLYSEFYQDSYFVRVRP KGQYPQTKEVYGSNFCDIAVTLDERTNRVTIVSVIDNLMKGAAGQAVQNFNLMNGWNE ETGLTITPIYP*" /label="argC CDS" gene 1144611..1145648 /gene="argC" /locus_tag="BSU_11190" /old_locus_tag="BSU11190" /label="argC gene" CDS 1145668..1146888 /gene="argJ" /locus_tag="BSU_11200" /old_locus_tag="BSU11200" /EC_number="2.3.1.1" /EC_number="2.3.1.35" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8025667, 10931207, 16409639, 24163341" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8025667, 10931207, 16409639, 24163341; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ornithine acetyltransferase; amino-acid acetyltransferase" /protein_id="NP_389002.2" /db_xref="EnsemblGenomes-Gn:BSU11200" /db_xref="EnsemblGenomes-Tr:CAB12961" /db_xref="GOA:P36843" /db_xref="InterPro:IPR002813" /db_xref="InterPro:IPR016117" /db_xref="SubtiList:BG10192" /db_xref="UniProtKB/Swiss-Prot:P36843" /translation="MIQLSEDQIVKVTGDVSSPKGFQAKGVHCGLRYSKKDLGVIISE TPAVSAAVYTQSHFQAAPIKVTQDSLKHGPTLKAVIVNSAIANACTGEQGLKDAYTMR ESFASQLGIEPELVAVSSTGVIGEHLDMEKIHAGIELLKETPAGSGDFEEAILTTDTV IKQTCYELAIGGKTVTIGGAAKGSGMIHPNMATMLGFVTTDAAIEEKALQKALREITD VSFNQITVDGETSTNDMVLVMANGCAENECLTEDHPDWPVFKKALLLTCEDLAKEIAR DGEGATKLIEAQVQGAKNNLDANVIAKKIVGSNLVKTAVYGTDANWGRIIGAIGHSAA QVTAEEVEVYLGGQCLFKNNEPQPFSESIAKEYLEGDEITIVIKMAEGDGNGRAWGCD LTYDYIKINASYRT*" /label="argJ CDS" gene 1145668..1146888 /gene="argJ" /locus_tag="BSU_11200" /old_locus_tag="BSU11200" /label="argJ gene" CDS 1146903..1147679 /gene="argB" /locus_tag="BSU_11210" /old_locus_tag="BSU11210" /EC_number="2.7.2.8" /experiment="publication(s) with functional evidences, PMID:3005232, 8473852" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3005232, 8473852; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylglutamate 5-phosphotransferase (acetylglutamate kinase)" /protein_id="NP_389003.1" /db_xref="EnsemblGenomes-Gn:BSU11210" /db_xref="EnsemblGenomes-Tr:CAB12962" /db_xref="GOA:P68729" /db_xref="InterPro:IPR001048" /db_xref="InterPro:IPR001057" /db_xref="InterPro:IPR004662" /db_xref="InterPro:IPR036393" /db_xref="SubtiList:BG10193" /db_xref="UniProtKB/Swiss-Prot:P68729" /translation="MKKTIVFKCGGSVIRELSEEFYQNLKELRASGWKLAIVHGGGPE ITNMLKRLNIKTEFSGGQRKTTKPVLEVAEMVLSGSVNKFFVAELAKHGLRAAGISGK DGGLLEADYLDPETYGEVGEIKKVDASMVNALMENGIIPVIAPLSMTSDCKTLNVNAD LAASAVAGALEADKLMFVTDVDGIMKEKQRLDVLTPKEIQMLIKQEVITGGMIPKVNS ALSALSDQVSEVMIVNGKGSFFAEQTFQGTKIVKAKEAVS*" /label="argB CDS" gene 1146903..1147679 /gene="argB" /locus_tag="BSU_11210" /old_locus_tag="BSU11210" /label="argB gene" CDS 1147676..1148833 /gene="argD" /locus_tag="BSU_11220" /old_locus_tag="BSU11220" /EC_number="2.6.1.11" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17012789; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="N-acetylornithine aminotransferase" /protein_id="NP_389004.2" /db_xref="EnsemblGenomes-Gn:BSU11220" /db_xref="EnsemblGenomes-Tr:CAB12963" /db_xref="GOA:P36839" /db_xref="InterPro:IPR004636" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG10194" /db_xref="UniProtKB/Swiss-Prot:P36839" /translation="MSSLFQTYGRWDIDIKKAKGTYVEDQNGKTYLDFIQGIAVSNLG HCHEAVTEAVKKQLDSVWHVSNLFQNSLQEQAAQKLAAHSAGDLVFFCNSGAEANEGA IKLARKATGKTKIITFLQSFHGRTYAGMAATGQDKIKTGFGPMLGGFHYLPYNDPSAF KALGEEGDIAAVMLETVQGEGGVNPASAEFLSAVQSFCKEKQALLIIDEIQTGIGRTG KGFAYEHFGLSPDIITVAKGLGNGFPVGAVIGKKQLGEAFTPGSHGTTFGGNMLAMAA VNATLQIVFQPDFLQEAADKGAFLKEQLEAELKSPFVKQIRGKGLMLGIECDGPVADI IAELQTLGLLVLPAGPNVIRLLPPLTVTKDEIAEAVSKLKQAIAHHSAVNQ*" /label="argD CDS" gene 1147676..1148833 /gene="argD" /locus_tag="BSU_11220" /old_locus_tag="BSU11220" /label="argD gene" CDS 1148904..1149959 /gene="carA" /locus_tag="Delta6_BSU_11230_SNPvariant" /old_locus_tag="BSU_11230" /EC_number="6.3.5.5" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:216664, 230177, 1116335" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 216664, 230177, 1116335; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arginine-specific carbamoyl-phosphate synthetase(small subunit)" /protein_id="NP_389005.2" /db_xref="EnsemblGenomes-Gn:BSU11230" /db_xref="EnsemblGenomes-Tr:CAB12964" /db_xref="GOA:P36838" /db_xref="InterPro:IPR002474" /db_xref="InterPro:IPR006274" /db_xref="InterPro:IPR017926" /db_xref="InterPro:IPR029062" /db_xref="InterPro:IPR035686" /db_xref="InterPro:IPR036480" /db_xref="SubtiList:BG10195" /db_xref="UniProtKB/Swiss-Prot:P36838" /modified_by="User" /translation="MEGYLVLEDGTSFSGELDGHENCTGEAVFFTGMTGYQEVLTDPS YKGQIIVFTYPLIGNYGINEKDFESKKPQVKAAVVYEACDHFSHYEAVYSLKEYLQKW NIPLLTHVDTRAVVKKIRANGTMGATVTASKEGAEIALQPENVAEQASAQEISTFGDG NKHIALIDFGYKKSIASSLVKRGCKVTVVPYQQMEAVYNIKPDGLSNGPGDPKAIQPY LGKIKSIISRFPTLGICLGHQLIALAFGGNTFKLPFGHRGANHPVIDRKTKRVFMTSQ NHSYVVDEQSINEEELTIRFHHVNDTSVEGLAHKKLPVMSVQFHPEAHPGPAESEWIF DDYLKNVIPARREIAHA*" /label="Delta6_BSU_11230_SNPvariant" gene 1148904..1149959 /gene="carA" /locus_tag="Delta6_BSU_11230_SNPvariant" /old_locus_tag="BSU_11230" /modified_by="User" /label="Delta6_BSU_11230_SNPvariant" Polymorphism join(1149514,1149515) /Source="geneious" /ID="SNP_BsDelta6_1199938_1199943" /Polymorphism_Type="Deletion" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=6 /Amino_Acid_Change="GIV -> G" /CDS_Position=612 /Change="-AATTGT" /Codon_Change="GGA,ATT,GTG -> GGG" /Coverage="183 -> 185" /locus_tag="BSU_11230" /Protein_Effect="Deletion" /Reference_Frequency /Reference_Nucleotides="AATTGT" /Variant_Nucleotides /Variant_P_Value=0 /Variant_Raw_Frequency=174 /comment="Delta6_BSU_11230_SNPvariant" / /modified_by="User" /label="Polymorphism_Delta6" misc_feature complement(1149793..1149812) /Source="Nicolas_upshift_promotors" /id="U900" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.869130869130869" /psig="0.949050949050949" /xcortree=2066 /SigmaFactorBS="gtggaattgaacactcatgacaggcagttttttatgggcaag cccttcaacTGACGTATCATTGACATGATgaaacctgatggtgagctcttcttcatta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1149803) /Source="Nicolas_upshifts" /id="U900" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.869130869130869" /psig="0.949050949050949" /xcortree=2066 /SigmaFactorBS="gtggaattgaacactcatgacaggcagttttttatgggcaag cccttcaacTGACGTATCATTGACATGATgaaacctgatggtgagctcttcttcatta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1149952..1153044 /gene="carB" /locus_tag="BSU_11240" /old_locus_tag="BSU11240" /EC_number="6.3.5.5" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:216664, 1116335" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 216664, 1116335; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arginine-specific carbamoyl-phosphate synthetase(large subunit)" /protein_id="NP_389006.3" /db_xref="EnsemblGenomes-Gn:BSU11240" /db_xref="EnsemblGenomes-Tr:CAB12965" /db_xref="GOA:P18185" /db_xref="InterPro:IPR005479" /db_xref="InterPro:IPR005480" /db_xref="InterPro:IPR005483" /db_xref="InterPro:IPR006275" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="InterPro:IPR036897" /db_xref="SubtiList:BG10196" /db_xref="UniProtKB/Swiss-Prot:P18185" /translation="MPKDTSISSILVIGSGPIIIGQAAEFDYSGTQGCIALKEEGYRV ILVNSNPATIMTDEAFADEIYFEPLTAESLTAIIKKERPDGLLANLGGQTALNLAVEL EETGVLKEHGVKLLGTSVETIQKGEDREKFRSLMNELKQPVPESEIVDNEADALHFAE SIGFPVIIRPAYTLGGKGGGIAPDKEAFTAMIKQALLASPINQCLVEKSIAGFKEIEY EVMRDSNNTCITVCNMENIDPVGVHTGDSIVVAPSQTLTDEDYQMLRTASLTIISALD VVGGCNIQFALDPFSKQYYVIEVNPRVSRSSALASKATGYPIAKMAAKLAVGYTLDEL KNPLTGSTYASFEPALDYVIVKFPRWPFDKFKNADRKLGTKMKATGEVMAIERNLEAA IQKAAASLELKNIGTHLPELSGLSIDTLWDLAITPDDRRFFVVMELLSRSVSIDDIHE KTKIDPFFLHTFDNIIKLENRLMEAGSDLSFELLKKAKEKGFSDATIASLISKTEEEV RALRKEMGITPSFKIVDTCAAEFDAKTNYFYSTYFGETDGDISRKEKKRALIIGSGPI RIGQGVEFDYSAVHGVLTLQELGFETIMINNNPETVSTDYEIADRLYFEPMTTEHIVN VAEQENIDFAIVQFGGQTAINAAEALEKAGITLLGTSFQTLDVLEDRDQFYQLLDELG LKHAKGEIAYTKEEAASKASEIGYPVLIRPSYVIGGMGMIIVDSQAQLSQLLNDEDSM PYPILIDQYVSGKEVEIDLISDGEEVFIPTYTEHIERAGVHSGDSFAILPGPSITSGL QQGMKDAAQKIARKLSFKGIMNIQFVIDNGNILVLEVNPRASRTVPVVSKVMGVPMIP LATRLLAGASLKDLNPAVQNHHGVAVKFPVFSSHAIQDVDVKLGPEMKSTGEGMCVAY DSNSALKKIYTRVWSQKGSIYLQNVPEDVKELAENAGFTIHEGTFASWMEQEGNSLHI NLSGSEEARKERLEAMTHGIPVFTEEETVRAFLQSGSGHPQPVSLKDLYKKEVASCTQ *" /label="carB CDS" gene 1149952..1153044 /gene="carB" /locus_tag="BSU_11240" /old_locus_tag="BSU11240" /label="carB gene" CDS 1153032..1153991 /gene="argF" /locus_tag="BSU_11250" /old_locus_tag="BSU11250" /EC_number="2.1.3.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3099126, 6409881, 8025667, 9346304, 16585758, 26443366" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3099126, 6409881, 8025667, 9346304, 16585758, 26443366; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ornithine carbamoyltransferase" /protein_id="NP_389007.1" /db_xref="EnsemblGenomes-Gn:BSU11250" /db_xref="EnsemblGenomes-Tr:CAB12966" /db_xref="GOA:P18186" /db_xref="InterPro:IPR002292" /db_xref="InterPro:IPR006130" /db_xref="InterPro:IPR006131" /db_xref="InterPro:IPR006132" /db_xref="InterPro:IPR024904" /db_xref="InterPro:IPR036901" /db_xref="SubtiList:BG10197" /db_xref="UniProtKB/Swiss-Prot:P18186" /translation="MHTVTQTSLYGKDLLTLKDLSEEDINALLAEAGELKQNKIQPIF HGKTLAMIFEKSSTRTRVSFEAGMAQLGGSALFLSQKDLQLGRGETVADTAKVLSGYV DAIMIRTFEHEKVEELAKEADIPVINGLTDKYHPCQALADLLTIKEIKGKLKGVKVAY IGDGNNVAHSLMIGCAKMGCDISIASPKGYEVLDEAAEAAKTYALQSGSSVTLTDDPI EAVKDADVIYSDVFTSMGQEAEEQERLAVFAPYQVNAALVSHAKPDYTFLHCLPAHRE EEVTAEIIDGPNSAVFQQAENRLHVQKALLKAILYKGESSKNC*" /label="argF CDS" gene 1153032..1153991 /gene="argF" /locus_tag="BSU_11250" /old_locus_tag="BSU11250" /label="argF gene" downshifts 1153954 /Source="Nicolas_upshifts" /id="D609" /incds=0 /nref=141 /ntot=268 /MaxReadThrough="4.29547" /MaxDrop="7.69347" /score="22.2660758" /energy="-11.1" /TU="U899" /idTUdmin="U899" /TUdmin="-305" /isTUend="FALSE" /label="downshifts" S_feature complement(1153994..1154268) /Source="Nicolas_S_feature" /locus_tag="new_1204423_1204697_c" /HighExp="G135, G180, Cold, LBGexp, G150, B60, LoTm, Paraq, Oxctl, H2O2" /AntisenseName="yjzC" /AntisenseCor="-0.37122740772860502" /AntisenseRegPval="-9.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S399" promotor_-35 1154019..1154025 /Source="Nicolas_upshift_promotors" /id="U901" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=943 /SigmaFactorBS="agcagtttttttgatggcAACATATtcacagccgcttagGCG CATACTACAgcaaaaaggaaaaggaggaaaaacagtgggacagcagcaccaattccgg c" /listShort="yjzC" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1154027) /Source="Nicolas_upshifts" /id="D610" /incds=0 /nref=33 /ntot=166 /MaxReadThrough="1.19008" /MaxDrop="5.22155" /score="16.2777759" /energy="-11.2" /TU="NA" /idTUdmin="U902" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 1154040..1154051 /Source="Nicolas_upshift_promotors" /id="U901" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=943 /SigmaFactorBS="agcagtttttttgatggcAACATATtcacagccgcttagGCG CATACTACAgcaaaaaggaaaaggaggaaaaacagtgggacagcagcaccaattccgg c" /listShort="yjzC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1154061 /Source="Nicolas_upshifts" /id="U901" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=943 /SigmaFactorBS="agcagtttttttgatggcAACATATtcacagccgcttagGCG CATACTACAgcaaaaaggaaaaggaggaaaaacagtgggacagcagcaccaattccgg c" /listShort="yjzC" /GFF_Attribute="listLong" /label="upshifts" CDS 1154077..1154256 /gene="yjzC" /locus_tag="BSU_11260" /old_locus_tag="BSU11260" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 25859258" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389008.1" /db_xref="EnsemblGenomes-Gn:BSU11260" /db_xref="EnsemblGenomes-Tr:CAB12967" /db_xref="InterPro:IPR025549" /db_xref="SubtiList:BG13223" /db_xref="UniProtKB/Swiss-Prot:O34585" /translation="MGQQHQFRPGQKAPNNGVYVEIGETGSMVKNPQKVHLSAGEMFP ETSNHNRLWTYKRKP*" /label="yjzC CDS" gene 1154077..1154256 /gene="yjzC" /locus_tag="BSU_11260" /old_locus_tag="BSU11260" /label="yjzC gene" downshifts 1154266 /Source="Nicolas_upshifts" /id="D611" /incds=0 /nref=19 /ntot=53 /MaxReadThrough="0.25116" /MaxDrop="5.67653" /score="4.8153862" /energy="-10.9" /TU="NA" /idTUdmin="U899" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS complement(1154302..1154487) /gene="yjzD" /locus_tag="BSU_11270" /old_locus_tag="BSU11270" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:19775244" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19775244; Product type f: factor" /codon_start=1 /transl_table=11 /product="forespore targeted protein" /protein_id="NP_389009.1" /db_xref="EnsemblGenomes-Gn:BSU11270" /db_xref="EnsemblGenomes-Tr:CAB12968" /db_xref="GOA:O34713" /db_xref="InterPro:IPR021324" /db_xref="SubtiList:BG13224" /db_xref="UniProtKB/Swiss-Prot:O34713" /translation="MRYIIAFIWTFLLSHMACYLVASMNSVTYNFKTSSVIAVVLYVL IMVLAEIMPMNKNASQH*" /label="yjzD CDS" gene complement(1154302..1154487) /gene="yjzD" /locus_tag="BSU_11270" /old_locus_tag="BSU11270" /label="yjzD gene" downshifts complement(1154313) /Source="Nicolas_upshifts" /id="D612" /incds=0 /nref=215 /ntot=261 /MaxReadThrough="3.91391" /MaxDrop="6.26103" /score="9.62656276" /energy="-10.9" /TU="U902" /idTUdmin="U902" /TUdmin="-286" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1154516..1154535) /Source="Nicolas_upshift_promotors" /id="U902" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.94005994005994" /psig=1 /xcortree=3093 /SigmaFactorBS="atcagactcttttgtcacctcactttctgctaaaattggaTT CCCCCTtcgctttttgTATGGTATGATAACTTTTAGaatagaatgagaaggacgaggt g" /listShort="yjzD, S399" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1154533) /Source="Nicolas_upshifts" /id="U902" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.94005994005994" /psig=1 /xcortree=3093 /SigmaFactorBS="atcagactcttttgtcacctcactttctgctaaaattggaTT CCCCCTtcgctttttgTATGGTATGATAACTTTTAGaatagaatgagaaggacgaggt g" /listShort="yjzD, S399" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1154546..1154553) /Source="Nicolas_upshift_promotors" /id="U902" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.94005994005994" /psig=1 /xcortree=3093 /SigmaFactorBS="atcagactcttttgtcacctcactttctgctaaaattggaTT CCCCCTtcgctttttgTATGGTATGATAACTTTTAGaatagaatgagaaggacgaggt g" /listShort="yjzD, S399" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1154588..1154594 /Source="Nicolas_upshift_promotors" /id="U903" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.972027972027972" /psig=1 /xcortree=3055 /SigmaFactorBS="gaatccaattttagcagaaagtgaggtgacaaaagagTCTGA TTcgtcacactttAATGGTAAAATATAAAACGTcaatcagtataatagccaaaaatgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1154606..1154625 /Source="Nicolas_upshift_promotors" /id="U903" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.972027972027972" /psig=1 /xcortree=3055 /SigmaFactorBS="gaatccaattttagcagaaagtgaggtgacaaaagagTCTGA TTcgtcacactttAATGGTAAAATATAAAACGTcaatcagtataatagccaaaaatgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1154611 /Source="Nicolas_upshifts" /id="U903" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.972027972027972" /psig=1 /xcortree=3055 /SigmaFactorBS="gaatccaattttagcagaaagtgaggtgacaaaagagTCTGA TTcgtcacactttAATGGTAAAATATAAAACGTcaatcagtataatagccaaaaatgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1154668..1154677 /Source="Nicolas_upshift_promotors" /id="U904" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1435 /SigmaFactorBS="ataaaacgtcaatcagtataatagccaaaaatgtaaaaggct aggactttaCCTTATTCGTttcttttctattTACATAAGATAGCGTGAGATgaagtgt g" /listShort="yjaU, yjaV, med" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1154677 /Source="Nicolas_upshifts" /id="U904" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1435 /SigmaFactorBS="ataaaacgtcaatcagtataatagccaaaaatgtaaaaggct aggactttaCCTTATTCGTttcttttctattTACATAAGATAGCGTGAGATgaagtgt g" /listShort="yjaU, yjaV, med" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1154690..1154709 /Source="Nicolas_upshift_promotors" /id="U904" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1435 /SigmaFactorBS="ataaaacgtcaatcagtataatagccaaaaatgtaaaaggct aggactttaCCTTATTCGTttcttttctattTACATAAGATAGCGTGAGATgaagtgt g" /listShort="yjaU, yjaV, med" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1154736..1155470 /gene="yjaU" /locus_tag="BSU_11280" /old_locus_tag="BSU11280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 18582593" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389010.1" /db_xref="EnsemblGenomes-Gn:BSU11280" /db_xref="EnsemblGenomes-Tr:CAB12969" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG13124" /db_xref="UniProtKB/Swiss-Prot:O35001" /translation="MGITERYFQLGTEHNVIHLPYRPNGFGIFILGDRTHFVGHDSSF WQQHYGRNQLLSMLMNEGYTLFNSNLFGRHWGAEKAVTYAKQLIHSVLKQEILNPKIH ILAEGMGALVADELLRFSPDHIRSAAMLNPCLDLQAHYESEKENKFFYKQFLKEVSKS YGISEKEAEAIRYKTIQSYPSGVPVHIWQRMTGAPYPYSVHAEVFKEKQQKQGSPVDM TFHLFEHPSRIYASICKFFHSHEKEL*" /label="yjaU CDS" gene 1154736..1155470 /gene="yjaU" /locus_tag="BSU_11280" /old_locus_tag="BSU11280" /label="yjaU gene" S_feature complement(1155229..1155831) /Source="Nicolas_S_feature" /locus_tag="new_1205658_1206260_c" /HighExp="S8, S6, S7, C30, BT, S4, S5, Pyr, S3, C90" /AntisenseName="yjaV" /AntisenseCor="0.66207512383157796" /AntisenseRegPval="-34.6" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.468" /TUlongSig="NA" /TUlongPSig="NA" /label="S400" promotor_-35 1155451..1155456 /Source="Nicolas_upshift_promotors" /id="U905" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1036 /SigmaFactorBS="atccaagcagaatttatgcatcaatttgcaaattctttcata GTCATGaaaaagaattatagaGAATATAATGACAACAGCCttctcttttgcggaggct g" /listShort="yjaV, med, comZ" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1155469 /Source="Nicolas_upshifts" /id="D613" /incds=0 /nref=6 /ntot=47 /MaxReadThrough="5.56163" /MaxDrop="4.5381" /score="1.90624641" /energy="-10" /TU="U904,U905" /idTUdmin="U904" /TUdmin="-945" /isTUend="FALSE" /label="downshifts" upshifts 1155469 /Source="Nicolas_upshifts" /id="U905" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1036 /SigmaFactorBS="atccaagcagaatttatgcatcaatttgcaaattctttcata GTCATGaaaaagaattatagaGAATATAATGACAACAGCCttctcttttgcggaggct g" /listShort="yjaV, med, comZ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1155472..1155490 /Source="Nicolas_upshift_promotors" /id="U905" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1036 /SigmaFactorBS="atccaagcagaatttatgcatcaatttgcaaattctttcata GTCATGaaaaagaattatagaGAATATAATGACAACAGCCttctcttttgcggaggct g" /listShort="yjaV, med, comZ" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1155552..1156109 /gene="yjaV" /locus_tag="BSU_11290" /old_locus_tag="BSU11290" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14523133; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD(P) binding enzyme" /protein_id="NP_389011.2" /db_xref="EnsemblGenomes-Gn:BSU11290" /db_xref="EnsemblGenomes-Tr:CAB12970" /db_xref="SubtiList:BG13125" /db_xref="UniProtKB/Swiss-Prot:O34959" /translation="MESTLIVGADEFFGLSLCERMMDEGIHVDVVLAETEDKMRQMYL EERLMWLGRNELFRQLEHIGDQNYDTICIQFGSFLPLDQYDSPYILVYEEDRKEWDKR EKTGSEKTVILPKMYGPWKEETEEDGYYTNDVADELLRFLLEPSRHSKDQLFELQVTE KTSKEEAKTKIIEWKRQFSSIFDKY*" /label="yjaV CDS" gene 1155552..1156109 /gene="yjaV" /locus_tag="BSU_11290" /old_locus_tag="BSU11290" /label="yjaV gene" promotor_-10 complement(1155811..1155830) /Source="Nicolas_upshift_promotors" /id="U906" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.467532467532468" /psig="0.467532467532468" /xcortree=771 /SigmaFactorBS="gcaggatcacggttttttccgagcctgttttttcacgtttat CCCATtcttttcggtcttcTTCATATACTAAAATATAAGgagaatcatattggtctaa a" /listShort="S400" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1155831) /Source="Nicolas_upshifts" /id="U906" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.467532467532468" /psig="0.467532467532468" /xcortree=771 /SigmaFactorBS="gcaggatcacggttttttccgagcctgttttttcacgtttat CCCATtcttttcggtcttcTTCATATACTAAAATATAAGgagaatcatattggtctaa a" /listShort="S400" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1155845..1155849) /Source="Nicolas_upshift_promotors" /id="U906" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.467532467532468" /psig="0.467532467532468" /xcortree=771 /SigmaFactorBS="gcaggatcacggttttttccgagcctgttttttcacgtttat CCCATtcttttcggtcttcTTCATATACTAAAATATAAGgagaatcatattggtctaa a" /listShort="S400" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1156116..1156123 /Source="Nicolas_upshift_promotors" /id="U907" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.689310689310689" /psig=1 /xcortree=2121 /SigmaFactorBS="caattttcgacaaatattaagaaaaaCCTTCCATgtttcgag ttttctAGATACAATAAACGTATAAAaataatacatgttatagcttgtcaaaaggagt t" /listShort="med, comZ, S401" /listLong="fabHA, fabF" /label="promotor_-35" promotor_-10 1156138..1156157 /Source="Nicolas_upshift_promotors" /id="U907" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.689310689310689" /psig=1 /xcortree=2121 /SigmaFactorBS="caattttcgacaaatattaagaaaaaCCTTCCATgtttcgag ttttctAGATACAATAAACGTATAAAaataatacatgttatagcttgtcaaaaggagt t" /listShort="med, comZ, S401" /listLong="fabHA, fabF" /label="promotor_-10" upshifts 1156150 /Source="Nicolas_upshifts" /id="U907" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.689310689310689" /psig=1 /xcortree=2121 /SigmaFactorBS="caattttcgacaaatattaagaaaaaCCTTCCATgtttcgag ttttctAGATACAATAAACGTATAAAaataatacatgttatagcttgtcaaaaggagt t" /listShort="med, comZ, S401" /listLong="fabHA, fabF" /label="upshifts" CDS 1156200..1157153 /gene="med" /locus_tag="BSU_11300" /old_locus_tag="BSU11300" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1203607, 21622736, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1203607, 21622736, 22720735; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="positive regulator of comK" /protein_id="NP_389012.2" /db_xref="EnsemblGenomes-Gn:BSU11300" /db_xref="EnsemblGenomes-Tr:CAB12971" /db_xref="GOA:O32436" /db_xref="InterPro:IPR003760" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG13126" /db_xref="UniProtKB/Swiss-Prot:O32436" /translation="MITRLVMIFSVLLLLSGCGQTPFKGKIEKVGMLFPDTINDLVWG TKGYKGLLNIQSKYNVDVYYKEGVKTEEDIINAIEDFHKRGVNLLYGHGSEYAEVFNL VGEDYPDMEFVISNAKAKADNVTSVHFSGEAMGFFGGMTAAHMSKTNQVGVIASFTWQ PEVDGFIKGAKYENPDIEVNTKYTDHWDDDTTAVKLYQKMKNEGADVVYPAGDGYNVP VIQQIKKDGLYAIGYVTDQSDLGENTVLTSTVQNVDKAYEIIAEQFNKGTLEGGDHYY DLNTGVVEMGTFSPLVDQDFQQRIAKLIKTYNKTGELPKNE*" /label="med CDS" gene 1156200..1157153 /gene="med" /locus_tag="BSU_11300" /old_locus_tag="BSU11300" /label="med gene" promotor_-35 1156817..1156821 /Source="Nicolas_upshift_promotors" /id="U908" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=1825 /SigmaFactorBS="tcagaaaatgaagaacgaaggcgcggaTGTTGtgtatcccgc cggagACGGGTATAATGTTCCTGTTattcagcaaatcaaaaaagacggtctttatgcc a" /listShort="comZ, S401" /listLong="fabHA, fabF" /label="promotor_-35" promotor_-10 1156837..1156856 /Source="Nicolas_upshift_promotors" /id="U908" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=1825 /SigmaFactorBS="tcagaaaatgaagaacgaaggcgcggaTGTTGtgtatcccgc cggagACGGGTATAATGTTCCTGTTattcagcaaatcaaaaaagacggtctttatgcc a" /listShort="comZ, S401" /listLong="fabHA, fabF" /label="promotor_-10" upshifts 1156850 /Source="Nicolas_upshifts" /id="U908" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=1825 /SigmaFactorBS="tcagaaaatgaagaacgaaggcgcggaTGTTGtgtatcccgc cggagACGGGTATAATGTTCCTGTTattcagcaaatcaaaaaagacggtctttatgcc a" /listShort="comZ, S401" /listLong="fabHA, fabF" /label="upshifts" CDS 1157168..1157359 /gene="comZ" /locus_tag="BSU_11310" /old_locus_tag="BSU11310" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10940045; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative late competence gene" /protein_id="NP_389013.1" /db_xref="EnsemblGenomes-Gn:BSU11310" /db_xref="EnsemblGenomes-Tr:CAB12972" /db_xref="GOA:O32437" /db_xref="InterPro:IPR024558" /db_xref="SubtiList:BG13221" /db_xref="UniProtKB/Swiss-Prot:O32437" /translation="MQHEKSLEFLQIAMKYLPEAKEQLEKSGIELSMEAIQPFMNLFT TVMAEAYELGKSDAKSETE*" /label="comZ CDS" gene 1157168..1157359 /gene="comZ" /locus_tag="BSU_11310" /old_locus_tag="BSU11310" /label="comZ gene" downshifts 1157338 /Source="Nicolas_upshifts" /id="D614" /incds=0 /nref=32 /ntot=192 /MaxReadThrough="4.56858" /MaxDrop="3.45953" /score="-7.49795364" /energy="-10.4" /TU="U907,U908" /idTUdmin="U905" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1157383..1157723 /Source="Nicolas_S_feature" /locus_tag="new_1207812_1208152" /HighExp="H2O2, C30, G135, Paraq, G180, G150, Oxctl, Cold, dia15, LPh" /AntisenseName="yjzB" /AntisenseCor="-0.34349942363230701" /AntisenseRegPval="-8.1" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S401" CDS complement(1157389..1157628) /gene="yjzB" /locus_tag="BSU_11320" /old_locus_tag="BSU11320" /experiment="publication(s) with functional evidences, PMID:16391061, 22171814, 27227299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16391061, 22171814, 27227299; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein" /protein_id="NP_389014.1" /db_xref="EnsemblGenomes-Gn:BSU11320" /db_xref="EnsemblGenomes-Tr:CAB12973" /db_xref="SubtiList:BG13222" /db_xref="UniProtKB/Swiss-Prot:O34891" /translation="MQLDVFSRMMFGDAAKPTEEKEEEQQEEVSQVSQTNDEETINYM HIMDQIGSIMNSLDQIKPALKELAPMLSAIKKKIM*" /label="yjzB CDS" gene complement(1157389..1157628) /gene="yjzB" /locus_tag="BSU_11320" /old_locus_tag="BSU11320" /label="yjzB gene" downshifts complement(1157405) /Source="Nicolas_upshifts" /id="D615" /incds=0 /nref=21 /ntot=48 /MaxReadThrough="1.43519" /MaxDrop="5.47891" /score="-7.75082002" /energy="-10.4" /TU="NA" /idTUdmin="U909" /TUdmin="-13" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1157641..1157660) /Source="Nicolas_upshift_promotors" /id="U909" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1358 /SigmaFactorBS="ctaattctatcctattttttttcacatggcaatatattcGTC TAAACTAtcagttcatcttaCTCATAGAGTATGGTATATGgaaaggaggcgtatgcag t" /listShort="yjzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1157662) /Source="Nicolas_upshifts" /id="U909" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1358 /SigmaFactorBS="ctaattctatcctattttttttcacatggcaatatattcGTC TAAACTAtcagttcatcttaCTCATAGAGTATGGTATATGgaaaggaggcgtatgcag t" /listShort="yjzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1157674..1157683) /Source="Nicolas_upshift_promotors" /id="U909" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1358 /SigmaFactorBS="ctaattctatcctattttttttcacatggcaatatattcGTC TAAACTAtcagttcatcttaCTCATAGAGTATGGTATATGgaaaggaggcgtatgcag t" /listShort="yjzB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1157689..1157696 /Source="Nicolas_upshift_promotors" /id="U910" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.858141858141858" /psig=1 /xcortree=2188 /SigmaFactorBS="atgaactgatagtttagacgaataTATTGCCAtgtgaaaaaa aataGGATAGAATTAGTACCTGATactaataattgatcacaacctgattgatcttcta a" /listShort="fabHA, fabF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1157711..1157730 /Source="Nicolas_upshift_promotors" /id="U910" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.858141858141858" /psig=1 /xcortree=2188 /SigmaFactorBS="atgaactgatagtttagacgaataTATTGCCAtgtgaaaaaa aataGGATAGAATTAGTACCTGATactaataattgatcacaacctgattgatcttcta a" /listShort="fabHA, fabF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1157725 /Source="Nicolas_upshifts" /id="U910" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.858141858141858" /psig=1 /xcortree=2188 /SigmaFactorBS="atgaactgatagtttagacgaataTATTGCCAtgtgaaaaaa aataGGATAGAATTAGTACCTGATactaataattgatcacaacctgattgatcttcta a" /listShort="fabHA, fabF" /GFF_Attribute="listLong" /label="upshifts" CDS 1157793..1158731 /gene="fabHA" /locus_tag="BSU_11330" /old_locus_tag="BSU11330" /EC_number="2.3.1.180" /EC_number="2.3.1.38" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10629181, 11959561, 21542858, 25196128" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10629181, 11959561, 21542858, 25196128; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="beta-ketoacyl-acyl carrier protein synthase III 1" /protein_id="NP_389015.1" /db_xref="EnsemblGenomes-Gn:BSU11330" /db_xref="EnsemblGenomes-Tr:CAB12974" /db_xref="GOA:O34746" /db_xref="InterPro:IPR004655" /db_xref="InterPro:IPR013747" /db_xref="InterPro:IPR013751" /db_xref="InterPro:IPR016039" /db_xref="SubtiList:BG13127" /db_xref="UniProtKB/Swiss-Prot:O34746" /translation="MKAGILGVGRYIPEKVLTNHDLEKMVETSDEWIRTRTGIEERRI AADDVFSSHMAVAAAKNALEQAEVAAEDLDMILVATVTPDQSFPTVSCMIQEQLGAKK ACAMDISAACAGFMYGVVTGKQFIESGTYKHVLVVGVEKLSSITDWEDRNTAVLFGDG AGAAVVGPVSDDRGILSFELGADGTGGQHLYLNEKRHTIMNGREVFKFAVRQMGESCV NVIEKAGLSKEDVDFLIPHQANIRIMEAARERLELPVEKMSKTVHKYGNTSAASIPIS LVEELEAGKIKDGDVVVMVGFGGGLTWGAIAIRWGR*" /label="fabHA CDS" gene 1157793..1158731 /gene="fabHA" /locus_tag="BSU_11330" /old_locus_tag="BSU11330" /label="fabHA gene" promotor_-35 1157870..1157879 /Source="Nicolas_upshift_promotors" /id="U911" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=1791 /SigmaFactorBS="tcctgagaaggttttaacaaatcatgatcttgaaaaaatggt TGAAACTTCTgacgagtggatTCGTACAAGAACAGGAatagaagaaagaagaatcgca g" /listShort="fabF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1157888 /Source="Nicolas_upshifts" /id="U911" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=1791 /SigmaFactorBS="tcctgagaaggttttaacaaatcatgatcttgaaaaaatggt TGAAACTTCTgacgagtggatTCGTACAAGAACAGGAatagaagaaagaagaatcgca g" /listShort="fabF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1157891..1157906 /Source="Nicolas_upshift_promotors" /id="U911" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=1791 /SigmaFactorBS="tcctgagaaggttttaacaaatcatgatcttgaaaaaatggt TGAAACTTCTgacgagtggatTCGTACAAGAACAGGAatagaagaaagaagaatcgca g" /listShort="fabF" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1158754..1159995 /gene="fabF" /locus_tag="BSU_11340" /old_locus_tag="BSU11340" /EC_number="2.3.1.41" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11325930, 12682299, 16436705, 18384517, 21542858, 28196402" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11325930, 12682299, 16436705, 18384517, 21542858, 28196402; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="beta-ketoacyl-acyl carrier protein synthase II (involved in pimelate synthesis)" /protein_id="NP_389016.1" /db_xref="EnsemblGenomes-Gn:BSU11340" /db_xref="EnsemblGenomes-Tr:CAB12975" /db_xref="GOA:O34340" /db_xref="InterPro:IPR014030" /db_xref="InterPro:IPR014031" /db_xref="InterPro:IPR016039" /db_xref="InterPro:IPR017568" /db_xref="InterPro:IPR018201" /db_xref="InterPro:IPR020841" /db_xref="PDB:4LS5" /db_xref="PDB:4LS6" /db_xref="PDB:4LS7" /db_xref="PDB:4LS8" /db_xref="SubtiList:BG13128" /db_xref="UniProtKB/Swiss-Prot:O34340" /translation="MTKKRVVVTGLGALSPLGNDVDTSWNNAINGVSGIGPITRVDAE EYPAKVAAELKDFNVEDYMDKKEARKMDRFTQYAVVAAKMAVEDADLNITDEIAPRVG VWVGSGIGGLETLESQFEIFLTKGPRRVSPFFVPMMIPDMATGQISIALGAKGVNSCT VTACATGTNSIGDAFKVIQRGDADVMVTGGTEAPLTRMSFAGFSANKALSTNPDPKTA SRPFDKNRDGFVMGEGAGIIVLEELEHALARGAKIYGEIVGYGSTGDAYHITAPAQDG EGGARAMQEAIKDAGIAPEEIDYINAHGTSTYYNDKYETMAIKTVFGEHAHKLAVSST KSMTGHLLGAAGGIEAIFSILAIKEGVIPPTINIQTPDEECDLDYVPDEARRQELNYV LSNSLGFGGHNATLIFKKYQS*" /label="fabF CDS" gene 1158754..1159995 /gene="fabF" /locus_tag="BSU_11340" /old_locus_tag="BSU11340" /label="fabF gene" promotor_-10 complement(1158968..1158986) /Source="Nicolas_upshift_promotors" /id="U912" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.813186813186813" /psig="0.813186813186813" /xcortree=777 /SigmaFactorBS="cggtaatgttaagatctgcatcttcaaccGCCATTttcgcag ccacaaccGCATATTGTGTAAAGCGGTccatttttctggcttcttttttatccatata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1158976) /Source="Nicolas_upshifts" /id="U912" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.813186813186813" /psig="0.813186813186813" /xcortree=777 /SigmaFactorBS="cggtaatgttaagatctgcatcttcaaccGCCATTttcgcag ccacaaccGCATATTGTGTAAAGCGGTccatttttctggcttcttttttatccatata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1159002..1159007) /Source="Nicolas_upshift_promotors" /id="U912" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.813186813186813" /psig="0.813186813186813" /xcortree=777 /SigmaFactorBS="cggtaatgttaagatctgcatcttcaaccGCCATTttcgcag ccacaaccGCATATTGTGTAAAGCGGTccatttttctggcttcttttttatccatata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1159846 /Source="Nicolas_upshifts" /id="D616" /incds=1 /nref=1 /ntot=89 /MaxReadThrough="7.03006" /MaxDrop="2.1101" /score="54.6350161" /energy="-18.5" /TU="U910,U911" /idTUdmin="U911" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" downshifts 1159979 /Source="Nicolas_upshifts" /id="D617" /incds=0 /nref=246 /ntot=274 /MaxReadThrough="0.58964" /MaxDrop="7.80446" /score="54.6350161" /energy="-18.5" /TU="NA" /idTUdmin="U911" /TUdmin=1 /isTUend="TRUE" /label="downshifts" promotor_-35 1160020..1160029 /Source="Nicolas_upshift_promotors" /id="U913" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1338 /SigmaFactorBS="tatcaatcataatcaagccaaaccggctgcccttaaAGGGTA GCCGgttttttttgtgTGCATAGGATTAAAAGAGGAggcgatcacatgagtgtagaac a" /listShort="yjaZ, S402, S403, appD, appF" /listLong="S404, appA, appA, appB, appC" /label="promotor_-35" promotor_-10 1160042..1160061 /Source="Nicolas_upshift_promotors" /id="U913" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1338 /SigmaFactorBS="tatcaatcataatcaagccaaaccggctgcccttaaAGGGTA GCCGgttttttttgtgTGCATAGGATTAAAAGAGGAggcgatcacatgagtgtagaac a" /listShort="yjaZ, S402, S403, appD, appF" /listLong="S404, appA, appA, appB, appC" /label="promotor_-10" upshifts 1160044 /Source="Nicolas_upshifts" /id="U913" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1338 /SigmaFactorBS="tatcaatcataatcaagccaaaccggctgcccttaaAGGGTA GCCGgttttttttgtgTGCATAGGATTAAAAGAGGAggcgatcacatgagtgtagaac a" /listShort="yjaZ, S402, S403, appD, appF" /listLong="S404, appA, appA, appB, appC" /label="upshifts" promotor_-35 1160056..1160064 /Source="Nicolas_upshift_promotors" /id="U914" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=544 /SigmaFactorBS="cggttttttttgtgtgcataggattaaaAGAGGAGGCgatca catgagTGTAGAACAAACATATAGCtggctcaggaaggccggttcaatagatgatttg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1160071..1160856 /gene="yjaZ" /locus_tag="BSU_11350" /old_locus_tag="BSU11350" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389017.1" /db_xref="EnsemblGenomes-Gn:BSU11350" /db_xref="EnsemblGenomes-Tr:CAB12992" /db_xref="InterPro:IPR018728" /db_xref="SubtiList:BG13129" /db_xref="UniProtKB/Swiss-Prot:O31596" /translation="MSVEQTYSWLRKAGSIDDLAHYIIPLFSGAEKKNWKGILGHLQH HGMFKNIKEGIQTVSKLKEKGFYGHIQKEEQYLKNKWQGPDVPIVTLPVDERNRRIRL EFGSKSGLAFQDKMFLFLSSDLDFGSVSALMTHEYHHVCRLGHLTKEEKDVTLLDTII MEGLAEYAVYERFGRSQTAEWTTWYTPEQLQALYEKKIAPHRDIKRDNRLFPQLLFGK GYQPKMLGYAVGFNIVKKYLTASKASTADGLSIPAETFLDAML*" /label="yjaZ CDS" gene 1160071..1160856 /gene="yjaZ" /locus_tag="BSU_11350" /old_locus_tag="BSU11350" /label="yjaZ gene" promotor_-10 1160076..1160094 /Source="Nicolas_upshift_promotors" /id="U914" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=544 /SigmaFactorBS="cggttttttttgtgtgcataggattaaaAGAGGAGGCgatca catgagTGTAGAACAAACATATAGCtggctcaggaaggccggttcaatagatgatttg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1160088 /Source="Nicolas_upshifts" /id="U914" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=544 /SigmaFactorBS="cggttttttttgtgtgcataggattaaaAGAGGAGGCgatca catgagTGTAGAACAAACATATAGCtggctcaggaaggccggttcaatagatgatttg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature 1160857..1160941 /Source="Nicolas_S_feature" /locus_tag="new_1211286_1211370" /HighExp="S6, S5, S8, S7, BT, S4, S3, B36, T5.0H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S402" promotor_-10 complement(1160873..1160891) /Source="Nicolas_upshift_promotors" /id="U915" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.838161838161838" /psig="0.838161838161838" /xcortree=1001 /SigmaFactorBS="tttatagttgtatattattacaatcattttgcaaaatcaAGA ATTttttaggataaatgTAATATTATTAATGAAATTccattattttatccttttaaag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1160890) /Source="Nicolas_upshifts" /id="U915" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.838161838161838" /psig="0.838161838161838" /xcortree=1001 /SigmaFactorBS="tttatagttgtatattattacaatcattttgcaaaatcaAGA ATTttttaggataaatgTAATATTATTAATGAAATTccattattttatccttttaaag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1160906..1160911) /Source="Nicolas_upshift_promotors" /id="U915" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.838161838161838" /psig="0.838161838161838" /xcortree=1001 /SigmaFactorBS="tttatagttgtatattattacaatcattttgcaaaatcaAGA ATTttttaggataaatgTAATATTATTAATGAAATTccattattttatccttttaaag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1160909..1160916 /Source="Nicolas_upshift_promotors" /id="U916" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98001998001998" /psig="0.999000999001" /xcortree=2876 /SigmaFactorBS="ataatattacatttatcctaaaaaatTCTTGATTttgcaaaa tgattgTAATAATATACAACTATAAAatttttcgataattcaatattatttattattt c" /listShort="S403, appD, appF, S404, appA, appA, appB, appC, S405, yjbA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1160931..1160950 /Source="Nicolas_upshift_promotors" /id="U916" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98001998001998" /psig="0.999000999001" /xcortree=2876 /SigmaFactorBS="ataatattacatttatcctaaaaaatTCTTGATTttgcaaaa tgattgTAATAATATACAACTATAAAatttttcgataattcaatattatttattattt c" /listShort="S403, appD, appF, S404, appA, appA, appB, appC, S405, yjbA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1160943..1161047 /Source="Nicolas_S_feature" /locus_tag="new_1211372_1211476" /HighExp="LoTm, T4.0H, T3.0H, T5.0H, T3.30H, T2.30H, M9-stat, S1, T2.0H, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S403" upshifts 1160943 /Source="Nicolas_upshifts" /id="U916" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98001998001998" /psig="0.999000999001" /xcortree=2876 /SigmaFactorBS="ataatattacatttatcctaaaaaatTCTTGATTttgcaaaa tgattgTAATAATATACAACTATAAAatttttcgataattcaatattatttattattt c" /listShort="S403, appD, appF, S404, appA, appA, appB, appC, S405, yjbA" /GFF_Attribute="listLong" /label="upshifts" CDS 1161048..1162034 /gene="appD" /locus_tag="BSU_11360" /old_locus_tag="BSU11360" /EC_number="3.6.3.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7997159, 25755103, 26728191" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7997159, 25755103, 26728191; Product type t: transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (ATP-binding protein)" /protein_id="NP_389018.1" /db_xref="EnsemblGenomes-Gn:BSU11360" /db_xref="EnsemblGenomes-Tr:CAB12993" /db_xref="GOA:P42064" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013563" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11085" /db_xref="UniProtKB/Swiss-Prot:P42064" /translation="MSTLLEVNNLKTYFFRKKEPIPAVDGVDFHISKGETVALVGESG SGKSITSLSIMGLVQSSGGKIMDGSIKLEDKDLTSFTENDYCKIRGNEVSMIFQEPMT SLNPVLTIGEQITEVLIYHKNMKKKEARQRAVELLQMVGFSRAEQIMKEYPHRLSGGM RQRVMIAIALSCNPKLLIADEPTTALDVTIQAQVLELMKDLCQKFNTSILLITHDLGV VSEAADRVIVMYCGQVVENATVDDLFLEPLHPYTEGLLTSIPVIDGEIDKLNAIKGSV PTPDNLPPGCRFAPRCPKAMDKCWTNQPSLLTHKSGRTVRCFLYEEEGAEQS*" /label="appD CDS" gene 1161048..1162034 /gene="appD" /locus_tag="BSU_11360" /old_locus_tag="BSU11360" /label="appD gene" CDS 1162031..1163020 /gene="appF" /locus_tag="BSU_11370" /old_locus_tag="BSU11370" /EC_number="3.6.3.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7997159, 25755103, 26728191, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7997159, 25755103, 26728191, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (ATP-binding protein)" /protein_id="NP_389019.2" /db_xref="EnsemblGenomes-Gn:BSU11370" /db_xref="EnsemblGenomes-Tr:CAB12994" /db_xref="GOA:P42065" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013563" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11086" /db_xref="UniProtKB/Swiss-Prot:P42065" /translation="MTAANQETILELRDVKKYFPIRSGLFQRKVGDVKAVDGVSFSLK KGETLGIVGESGCGKSTAGRTMIRLYKPTEGQILFKGQDISNLSEEKLRKSVRKNIQM VFQDPFASLNPRKTLRSIIKEPFNTHNMYTMRERNEKVEELLARVGLHPSFAGRYPHE FSGGQRQRIGIARALTLNPELIIADEPVSALDVSIQAQVINLMEELQEEFNLTYLFIS HDLSVVRHISDRVGVMYLGKMMELTGKHELYDNPLHPYTQALLSSVPVTRKRGSVKRE RIVLKGELPSPANPPKGCVFHTRCPVAKPICKEQIPEFKEAAPSHFVACHLYS*" /label="appF CDS" gene 1162031..1163020 /gene="appF" /locus_tag="BSU_11370" /old_locus_tag="BSU11370" /label="appF gene" misc_feature 1163026..1163032 /Source="Nicolas_upshift_promotors" /id="U917" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.375624375624376" /psig="0.062937062937063" /xcortree=2877 /SigmaFactorBS="ttaaagaagctgctcccagccactttgtggcttgtcaccttt atagctaatgttgCCCGCACagctttgagagggggtatgcacactacataaacaacag c" /listShort="S404, appA, appA, appB, appC, S405, yjbA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1163031..1163107 /Source="Nicolas_S_feature" /locus_tag="new_1213460_1213536" /HighExp="T2.0H, S1, M9-stat, T5.0H, T3.0H, T1.30H, S2, M0t90, T2.30H, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.0629, 0.999" /TUlongSig="SigK" /TUlongPSig=1 /label="S404" upshifts 1163031 /Source="Nicolas_upshifts" /id="U917" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.375624375624376" /psig="0.062937062937063" /xcortree=2877 /SigmaFactorBS="ttaaagaagctgctcccagccactttgtggcttgtcaccttt atagctaatgttgCCCGCACagctttgagagggggtatgcacactacataaacaacag c" /listShort="S404, appA, appA, appB, appC, S405, yjbA" /GFF_Attribute="listLong" /label="upshifts" CDS 1163108..1163599 /gene="appAn" /locus_tag="BSU_11381" /old_locus_tag="BSU11381" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 15588833, 25355936; Product type rc: receptor" /pseudo /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (oligopeptide-binding lipoprotein); N-terminal part of AppA" /translation="MKRRKTALMMLSVLMVLAIFLSACSGSKSSNSSAKKSAGKPQQG GDLVVGSIGEPTLFNSLYSTDDASTDIENMLYSFLTKTDEKLNVKLSLAESIKELDGG LAYDVKIKKGVKFHDGKELTADDVVFTYSVPLSKDYKGERGSTYEMLKSVEKKAITKS CLS*" /label="appAn CDS" gene 1163108..1163599 /gene="appAn" /locus_tag="BSU_11381" /old_locus_tag="BSU11381" /pseudo /label="appAn gene" CDS 1163572..1164738 /gene="appAc" /locus_tag="BSU_11382" /old_locus_tag="BSU11382" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId: 7997159, 15588833, 26728191; Product type lp: lipoprotein" /pseudo /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (oligopeptide-binding lipoprotein); C-terminal part of AppA" /translation="GDYEVLFKLKYKDGNFYNNALDSTAILPKHILGNVPIADLEENE FNRKKPIGSGPFKFKEWKQGQYIKLEANDDYFEGRPYLDTVTYKVIPDANAAVAQLQA GDINFFNVPATDYKTAEKFNNLKIVTDLALSYVYIGWNEKNELFKDKKVRQALTTALD RESIVSQVLDGDGEVAYIPESPLSWNYPKDIDVPKFEYNEKKAKQMLAEAGWKDTNGD GILDKDGKKFSFTLKTNQGNKVREDIAVVVQEQLKKIGIEVKTQIVEWSALVEQMNPP NWDFDAMVMGWSLSTFPDQYDIFHSSQIKKGLNYVWYKNAEADKLMKDAKSISDRKQY SKEYEQIYQKIAEDQPYTFLYYPNNHMAMPENLEGYKYHPKRDLYNIEKWWLAK*" /label="appAc CDS" gene 1163572..1164738 /gene="appAc" /locus_tag="BSU_11382" /old_locus_tag="BSU11382" /pseudo /label="appAc gene" downshifts 1164729 /Source="Nicolas_upshifts" /id="D618" /incds=0 /nref=1 /ntot=49 /MaxReadThrough="7.71397" /MaxDrop="3.11667" /score="-1.00317393" /energy="-13.3" /TU="U916,U917" /idTUdmin="U913" /TUdmin=1715 /isTUend="FALSE" /label="downshifts" CDS 1164814..1165764 /gene="appB" /locus_tag="BSU_11390" /old_locus_tag="BSU11390" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7997159, 15849754, 16850406, 26728191" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7997159, 15849754, 16850406, 26728191; Product type t: transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (permease)" /protein_id="NP_389021.2" /db_xref="EnsemblGenomes-Gn:BSU11390" /db_xref="EnsemblGenomes-Tr:CAB12996" /db_xref="GOA:P42062" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11088" /db_xref="UniProtKB/Swiss-Prot:P42062" /translation="MAAYIIRRTLMSIPILLGITILSFVIMKAAPGDPMTLMMDPKIS QADREQFIEKYGLNDPQYVQYLKWLGNMVQGDFGTSIVRKGTPVSELIMARLPNTLLL MLVSTILALMISIPFGVLSAKRPYSKIDYGITFTSFIGLAIPNFWFGLILIMVLSVNL GWFPTGGVETLNTEFNIFDRIHHLILPAFVLATADMAGLTRYTRSNMLDVLNQDYIRT ARAKGFKENRVLFKHGLRNALLPVITIFGLMIPSFIGGSVVVEQIFTWPGLGKLFVDS AFQRDYPVIMAMTVISAVLVVVGNLIADILYAIVDPRIEY*" /label="appB CDS" gene 1164814..1165764 /gene="appB" /locus_tag="BSU_11390" /old_locus_tag="BSU11390" /label="appB gene" CDS 1165781..1166692 /gene="appC" /locus_tag="BSU_11400" /old_locus_tag="BSU11400" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7997159, 15849754, 16850406, 26728191" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7997159, 15849754, 16850406, 26728191; Product type t: transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (permease)" /protein_id="NP_389022.1" /db_xref="EnsemblGenomes-Gn:BSU11400" /db_xref="EnsemblGenomes-Tr:CAB12997" /db_xref="GOA:P42063" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR025966" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11089" /db_xref="UniProtKB/Swiss-Prot:P42063" /translation="MSELQTTPSPEIRLKENISKKPETMTKIFWEKFSKNKLAILGAV ILFIIIMSAVFAPLIAPYPQEQQSLLDKYKAPGLEHLMGTDKFGRDIFSRILYGARVS LLVGFASVVGSILIGTVLGALAGYFRGIVDAVIMRVVDIVLSIPDIFLLITLVTIFKP GVDKLILIFCLTGWTTTARLVRGEFLSLRSREYVLAAKTIGTKTHKIIFSHILPNALG PIIVSATLKVGSVILAESALSYLGFGIQPPIASWGNMLQDAQNFTVMIQAWWYPLFPG LFILMTVLCFNFVGDGLRDALDPKNIK*" /label="appC CDS" gene 1165781..1166692 /gene="appC" /locus_tag="BSU_11400" /old_locus_tag="BSU11400" /label="appC gene" downshifts 1166706 /Source="Nicolas_upshifts" /id="D619" /incds=0 /nref=62 /ntot=188 /MaxReadThrough="5.13927" /MaxDrop="5.50153" /score="22.0028545" /energy="-11.6" /TU="U916,U917" /idTUdmin="U916" /TUdmin="-923" /isTUend="FALSE" /label="downshifts" S_feature 1166751..1166858 /Source="Nicolas_S_feature" /locus_tag="new_1217180_1217287" /HighExp="LoTm, S1, S2, BT, T3.30H, T4.0H, T5.0H, T3.0H, Glu, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.0629, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S405" promotor_-35 1166831..1166836 /Source="Nicolas_upshift_promotors" /id="U918" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1160 /SigmaFactorBS="cccagtgattccagatttcctcaatctctttGGAATAatttc tctatcccttGCCTATACTGTGGACAACAgtttttataaaagtgaggggttagagatg t" /listShort="yjbA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1166852..1166870 /Source="Nicolas_upshift_promotors" /id="U918" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1160 /SigmaFactorBS="cccagtgattccagatttcctcaatctctttGGAATAatttc tctatcccttGCCTATACTGTGGACAACAgtttttataaaagtgaggggttagagatg t" /listShort="yjbA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1166860 /Source="Nicolas_upshifts" /id="U918" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1160 /SigmaFactorBS="cccagtgattccagatttcctcaatctctttGGAATAatttc tctatcccttGCCTATACTGTGGACAACAgtttttataaaagtgaggggttagagatg t" /listShort="yjbA" /GFF_Attribute="listLong" /label="upshifts" CDS 1166897..1167649 /gene="yjbA" /locus_tag="BSU_11410" /old_locus_tag="BSU11410" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11717292, 22882546; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative sporulation nucleic acid binding protein" /protein_id="NP_389023.1" /db_xref="EnsemblGenomes-Gn:BSU11410" /db_xref="EnsemblGenomes-Tr:CAB12998" /db_xref="InterPro:IPR020909" /db_xref="SubtiList:BG13130" /db_xref="UniProtKB/Swiss-Prot:O31597" /translation="MLFLHDVWVNWFEGEENGYNVCHFHEWRKEDTVELLDQVPLLRV PSVLFHYIENDLSELPKGLLEDVHQKSYIRKNHERTKLEYCFVVTDGIGILAVDTIGY TIPVRKSRLIPRQEQLVYEMVKDVEPETYEFEPKKLESSKEYHILSLAPEHVRGLTRK ERQIKQLMFMALDQLKGLKNRAEIGYWYTEWNPHMYEQIKRMSFEEIWDMLYNETIEG WSDKHLAFCENLIKGQPFFEKLWEMENESKVN*" /label="yjbA CDS" gene 1166897..1167649 /gene="yjbA" /locus_tag="BSU_11410" /old_locus_tag="BSU11410" /label="yjbA gene" downshifts 1167629 /Source="Nicolas_upshifts" /id="D620" /incds=0 /nref=32 /ntot=112 /MaxReadThrough="1.07428" /MaxDrop="6.2264" /score="22.0028545" /energy="-11.6" /TU="NA" /idTUdmin="U916" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1167684..1168676) /gene="trpS" /locus_tag="BSU_11420" /old_locus_tag="BSU11420" /EC_number="6.1.1.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8950174, 10706627, 12682299, 24572018" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8950174, 10706627, 12682299, 24572018; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tryptophanyl-tRNA synthetase" /protein_id="NP_389024.1" /db_xref="EnsemblGenomes-Gn:BSU11420" /db_xref="EnsemblGenomes-Tr:CAB12999" /db_xref="GOA:P21656" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR002305" /db_xref="InterPro:IPR002306" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR024109" /db_xref="PDB:3PRH" /db_xref="SubtiList:BG10799" /db_xref="UniProtKB/Swiss-Prot:P21656" /translation="MKQTIFSGIQPSGSVTLGNYIGAMKQFVELQHDYNSYFCIVDQH AITVPQDRLELRKNIRNLAALYLAVGLDPEKATLFIQSEVPAHAQAGWMMQCVAYIGE LERMTQFKDKSKGNEAVVSGLLTYPPLMAADILLYGTDLVPVGEDQKQHLELTRNLAE RFNKKYNDIFTIPEVKIPKVGARIMSLNDPLKKMSKSDPNQKAYITLLDEPKQLEKKI KSAVTDSEGIVKFDKENKPGVSNLLTIYSILGNTTIEELEAKYEGKGYGEFKGDLAEV VVNALKPIQDRYYELIESEELDRILDEGAERANRTANKMLKKMENAMGLGRKRR*" /label="trpS CDS" gene complement(1167684..1168676) /gene="trpS" /locus_tag="BSU_11420" /old_locus_tag="BSU11420" /label="trpS gene" downshifts complement(1167705) /Source="Nicolas_upshifts" /id="D621" /incds=0 /nref=224 /ntot=255 /MaxReadThrough="1.77115" /MaxDrop="6.72647" /score="27.6275522" /energy="-11.6" /TU="U919" /idTUdmin="U919" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" misc_RNA complement(1168735..1168949) /gene="tboWA" /locus_tag="BSU_misc_RNA_13" /product="T-box riboswitch specific of tryptophan tRNA" /experiment="publication(s) with functional evidences, PMID:8045882, 9098041, 10706627, 10943892, 11842119, 12165569, 12547201, 1317842" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045882, 9098041, 10706627, 10943892, 11842119, 12165569, 12547201, 1317842; Product type n: RNA" /function="16.3: Control" /label="tboWA RNA" gene complement(1168735..1168949) /gene="tboWA" /locus_tag="BSU_misc_RNA_13" /label="tboWA gene" downshifts complement(1168783) /Source="Nicolas_upshifts" /id="D622" /incds=0 /nref=37 /ntot=127 /MaxReadThrough="6.8472" /MaxDrop="5.13001" /score="25.1445248" /energy="-19" /TU="U919" /idTUdmin="U919" /TUdmin="-1100" /isTUend="FALSE" /label="downshifts" misc_feature complement(1168968..1168987) /Source="Nicolas_upshift_promotors" /id="U919" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.509490509490509" /psig="0.99100899100899" /xcortree=602 /SigmaFactorBS="tatttatattattacaattttactggaaaaaagaatgttttt tcatgatgacaaTTGGTTATAATTGATTTATAatgaagcaatcaaaagaaaagcttgc t" /listShort="NA, trpS" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1168981) /Source="Nicolas_upshifts" /id="U919" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.509490509490509" /psig="0.99100899100899" /xcortree=602 /SigmaFactorBS="tatttatattattacaattttactggaaaaaagaatgttttt tcatgatgacaaTTGGTTATAATTGATTTATAatgaagcaatcaaaagaaaagcttgc t" /listShort="NA, trpS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1169236..1169243 /Source="Nicolas_upshift_promotors" /id="U920" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.828171828171828" /psig=1 /xcortree=491 /SigmaFactorBS="aactaacgaagtttaaatattttaaattgataaaataaTATT GCAAtaaattatttgtttCATTATAATGAACTTGTTCActctattgttacagcttttt t" /listShort="S406, oppA, S407, oppB, oppC, oppD, oppF" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1169257..1169419 /Source="Nicolas_S_feature" /locus_tag="new_1219686_1219848" /HighExp="S1, T3.0H, T3.30H, T2.30H, T4.0H, T5.0H, LoTm, T2.0H, M40t90, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S406" promotor_-10 1169258..1169277 /Source="Nicolas_upshift_promotors" /id="U920" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.828171828171828" /psig=1 /xcortree=491 /SigmaFactorBS="aactaacgaagtttaaatattttaaattgataaaataaTATT GCAAtaaattatttgtttCATTATAATGAACTTGTTCActctattgttacagcttttt t" /listShort="S406, oppA, S407, oppB, oppC, oppD, oppF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1169258 /Source="Nicolas_upshifts" /id="U920" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.828171828171828" /psig=1 /xcortree=491 /SigmaFactorBS="aactaacgaagtttaaatattttaaattgataaaataaTATT GCAAtaaattatttgtttCATTATAATGAACTTGTTCActctattgttacagcttttt t" /listShort="S406, oppA, S407, oppB, oppC, oppD, oppF" /GFF_Attribute="listLong" /label="upshifts" CDS 1169420..1171057 /gene="oppA" /locus_tag="BSU_11430" /old_locus_tag="BSU11430" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1901616, 11083832, 11401703, 12823818, 15588833, 23133654, 26176322, 22720735, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1901616, 11083832, 11401703, 12823818, 15588833, 23133654, 26176322, 22720735, 25355936; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (binding lipoprotein)" /protein_id="NP_389025.1" /db_xref="EnsemblGenomes-Gn:BSU11430" /db_xref="EnsemblGenomes-Tr:CAB13000" /db_xref="GOA:P24141" /db_xref="InterPro:IPR000914" /db_xref="InterPro:IPR023765" /db_xref="InterPro:IPR030678" /db_xref="SubtiList:BG10771" /db_xref="UniProtKB/Swiss-Prot:P24141" /translation="MKKRWSIVTLMLIFTLVLSACGFGGSGSNGEGKKDSKGKTTLNI NIKTEPFSLHPGLANDSVSGGVIRQTFEGLTRINADGEPEEGMASKIETSKDGKTYTF TIRDGVKWSNGDPVTAQDFEYAWKWALDPNNESQYAYQLYYIKGAEAANTGKGSLDDV AVKAVNDKTLKVELNNPTPYFTELTAFYTYMPINKKIAEKNKKWNTNAGDDYVSNGPF KMTAWKHSGSITLEKNDQYWDKDKVKLKKIDMVMINNNNTELKKFQAGELDWAGMPLG QLPTESLPTLKKDGSLHVEPIAGVYWYKFNTEAKPLDNVNIRKALTYSLDRQSIVKNV TQGEQIPAMAAVPPTMKGFEDNKEGYFKDNDVKTAKEYLEKGLKEMGLSKASDLPKIK LSYNTDDAHAKIAQAVQEMWKKNLGVDVELDNSEWNVYIDKLHSQDYQIGRMGWLGDF NDPINFLELFRDKNGGNNDTGWENPEFKKLLNQSQTETDKTKRAELLKKAEGIFIDEM PVAPIYFYTDTWVQDENLKGVIMPGTGEVYFRNAYFK*" /label="oppA CDS" gene 1169420..1171057 /gene="oppA" /locus_tag="BSU_11430" /old_locus_tag="BSU11430" /label="oppA gene" downshifts 1170951 /Source="Nicolas_upshifts" /id="D623" /incds=1 /nref=8 /ntot=166 /MaxReadThrough="6.94127" /MaxDrop="3.3677" /score="-4.2761508" /energy="-15.6" /TU="U920" /idTUdmin="U916" /TUdmin=3322 /isTUend="FALSE" /label="downshifts" S_feature 1171058..1171164 /Source="Nicolas_S_feature" /locus_tag="new_1221487_1221593" /HighExp="S1, LoTm, T4.0H, BT, T3.30H, T3.0H, T5.0H, M0t90, T2.30H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S407" CDS 1171165..1172100 /gene="oppB" /locus_tag="BSU_11440" /old_locus_tag="BSU11440" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1901616, 11401703, 15849754, 16850406, 17600541, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1901616, 11401703, 15849754, 16850406, 17600541, 25355936; Product type t : transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (permease)" /protein_id="NP_389026.1" /db_xref="EnsemblGenomes-Gn:BSU11440" /db_xref="EnsemblGenomes-Tr:CAB13001" /db_xref="GOA:P24138" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG10772" /db_xref="UniProtKB/Swiss-Prot:P24138" /translation="MLKYIGRRLVYMIITLFVIVTVTFFLMQAAPGGPFSGEKKLPPE IEANLNAHYGLDKPLFVQYVSYLKSVAMWDFGPSFKYKGQSVNDLISSGFPVSFTLGA EAILLALALGVLFGVIAALYHNKWQDYTVAILTIFGISVPSFIMAAVLQYVFSMKLGL FPVAGWDSWAYTFLPSIALASMPMAFIARLSRSSMIEVLNSDYIRTAKAKGLSRPAVT VRHAIRNALLPVVTYMGPMAAQVLTGSFIIETIFGIPGLGAHFVNSITNRDYTVIMGV TVFFSVILLLCVLIVDVLYGIIDPRIKLSKAKKGA*" /label="oppB CDS" gene 1171165..1172100 /gene="oppB" /locus_tag="BSU_11440" /old_locus_tag="BSU11440" /label="oppB gene" promotor_-10 complement(1171208..1171227) /Source="Nicolas_upshift_promotors" /id="U921" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.508491508491508" /psig="0.97902097902098" /xcortree=1450 /SigmaFactorBS="gctttttctcacctgaaaatggcccgcccggtgctgCTTGCA TtaagaagaatgtcacAGTTACAATCACAAATAGTGtgataatcatatagactaagcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1171225) /Source="Nicolas_upshifts" /id="U921" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.508491508491508" /psig="0.97902097902098" /xcortree=1450 /SigmaFactorBS="gctttttctcacctgaaaatggcccgcccggtgctgCTTGCA TtaagaagaatgtcacAGTTACAATCACAAATAGTGtgataatcatatagactaagcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1171243..1171249) /Source="Nicolas_upshift_promotors" /id="U921" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.508491508491508" /psig="0.97902097902098" /xcortree=1450 /SigmaFactorBS="gctttttctcacctgaaaatggcccgcccggtgctgCTTGCA TtaagaagaatgtcacAGTTACAATCACAAATAGTGtgataatcatatagactaagcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1172104..1173021 /gene="oppC" /locus_tag="BSU_11450" /old_locus_tag="BSU11450" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1901616, 11401703, 15849754, 16850406, 26782429" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1901616, 11401703, 15849754, 16850406, 26782429; Product type t : transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (permease)" /protein_id="NP_389027.1" /db_xref="EnsemblGenomes-Gn:BSU11450" /db_xref="EnsemblGenomes-Tr:CAB13002" /db_xref="GOA:P24139" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR025966" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG10773" /db_xref="UniProtKB/Swiss-Prot:P24139" /translation="MQNIPKNMFEPAAANAGDAEKISKKSLSLWKDAMLRFRSNKLAM VGLIIIVLIILMAIFAPMFSRYDYSTTNLLNADKPPSKDHWFGTDDLGRDIFVRTWVG ARISIFIGVAAAVLDLLIGVIWGSISGFRGGRTDEIMMRIADILWAVPSLLMVILLMV VLPKGLFTIIIAMTITGWINMARIVRGQVLQLKNQEYVLASQTLGAKTSRLLFKHIVP NAMGSILVTMTLTVPTAIFTEAFLSYLGLGVPAPLASWGTMASDGLPALTYYPWRLFF PAGFICITMFGFNVVGDGLRDALDPKLRK*" /label="oppC CDS" gene 1172104..1173021 /gene="oppC" /locus_tag="BSU_11450" /old_locus_tag="BSU11450" /label="oppC gene" CDS 1173026..1174102 /gene="oppD" /locus_tag="BSU_11460" /old_locus_tag="BSU11460" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1901616, 11401703, 19202088, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1901616, 11401703, 19202088, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (ATP-binding protein)" /protein_id="NP_389028.1" /db_xref="EnsemblGenomes-Gn:BSU11460" /db_xref="EnsemblGenomes-Tr:CAB13003" /db_xref="GOA:P24136" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013563" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10774" /db_xref="UniProtKB/Swiss-Prot:P24136" /translation="MIRVTRLLEVKDLAISFKTYGGEVQAIRGVNFHLDKGETLAIVG ESGSGKSVTSQAIMKLIPMPPGYFKRGEILFEGKDLVPLSEKEMQNVRGKEIGMIFQD PMTSLNPTMKVGKQITEVLFKHEKISKEAAKKRAVELLELVGIPMPEKRVNQFPHEFS GGMRQRVVIAMALAANPKLLIADEPTTALDVTIQAQILELMKDLQKKIDTSIIFITHD LGVVANVADRVAVMYAGQIVETGTVDEIFYDPRHPYTWGLLASMPTLESSGEEELTAI PGTPPDLTNPPKGDAFALRSSYAMKIDFEQEPPMFKVSDTHYVKSWLLHPDAPKVEPP EAVKAKMRKLANTFEKPVLVREVE*" /label="oppD CDS" gene 1173026..1174102 /gene="oppD" /locus_tag="BSU_11460" /old_locus_tag="BSU11460" /label="oppD gene" CDS 1174104..1175021 /gene="oppF" /locus_tag="BSU_11470" /old_locus_tag="BSU11470" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1901616, 7997159, 11401703, 23133654, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1901616, 7997159, 11401703, 23133654, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (ATP-binding protein)" /protein_id="NP_389029.1" /db_xref="EnsemblGenomes-Gn:BSU11470" /db_xref="EnsemblGenomes-Tr:CAB13004" /db_xref="GOA:P24137" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013563" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10775" /db_xref="UniProtKB/Swiss-Prot:P24137" /translation="MTEKLLEIKHLKQHFVTPRGTVKAVDDLSFDIYKGETLGLVGES GCGKSTTGRSIIRLYEATDGEVLFNGENVHGRKSRKKLLEFNRKMQMIFQDPYASLNP RMTVADIIAEGLDIHKLAKTKKERMQRVHELLETVGLNKEHANRYPHEFSGGQRQRIG IARALAVDPEFIIADEPISALDVSIQAQVVNLMKELQKEKGLTYLFIAHDLSMVKYIS DRIGVMYFGKLVELAPADELYENPLHPYTKSLLSAIPLPDPDYERNRVRQKYDPSVHQ LKDGETMEFREVKPGHFVMCTEAEFKAFS*" /label="oppF CDS" gene 1174104..1175021 /gene="oppF" /locus_tag="BSU_11470" /old_locus_tag="BSU11470" /label="oppF gene" downshifts 1174991 /Source="Nicolas_upshifts" /id="D624" /incds=0 /nref=21 /ntot=196 /MaxReadThrough="1.58906" /MaxDrop="5.17491" /score="28.2861081" /energy="-15.2" /TU="NA" /idTUdmin="U920" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" promotor_-35 1175071..1175074 /Source="Nicolas_upshift_promotors" /id="U922" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.651348651348651" /psig="0.97002997002997" /xcortree=3166 /SigmaFactorBS="caatccttcaagagatttctcttgaaggatttttttgcgtct tcATAGaaagtgagaatgatAACATTTACAATTAGAGGAAaaagcggaggcgaaatac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1175087 /Source="Nicolas_upshifts" /id="U922" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.651348651348651" /psig="0.97002997002997" /xcortree=3166 /SigmaFactorBS="caatccttcaagagatttctcttgaaggatttttttgcgtct tcATAGaaagtgagaatgatAACATTTACAATTAGAGGAAaaagcggaggcgaaatac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1175089..1175108 /Source="Nicolas_upshift_promotors" /id="U922" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.651348651348651" /psig="0.97002997002997" /xcortree=3166 /SigmaFactorBS="caatccttcaagagatttctcttgaaggatttttttgcgtct tcATAGaaagtgagaatgatAACATTTACAATTAGAGGAAaaagcggaggcgaaatac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1175128..1176345 /gene="yjbB" /locus_tag="BSU_11480" /old_locus_tag="BSU11480" /function="16.1: Circulate" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14563878, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative exporter" /protein_id="NP_389030.2" /db_xref="EnsemblGenomes-Gn:BSU11480" /db_xref="EnsemblGenomes-Tr:CAB13005" /db_xref="GOA:O31600" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13131" /db_xref="UniProtKB/Swiss-Prot:O31600" /translation="MQFLHNKNVFALLLSQSFQSLAGVLVTIVLMVRIYQMTDSVFLA GLILSFMSFASIAASFCVSPVLRILGFKKVLAGANLLRAVFIILMAYSVTHHGQAFFW ITLLFVFCFSFAGAFFQPARFALLPIIVPKKQYVKANGVISLSNQLFLTAGWGLGGLL TYAVPFELVVGAAICLFVLSGASISVLHVNEEEAAGTAETASVRSIWKDLMIIPIVRD ITVMDMLEALAGSVWSSAILLAFTAAVLHETEVWWGMFNASYFIGAIVGSVIAIRFSS FFERNMGYAIMFSSLVMSALTLLFSFSPVPFLCALACAAMGPFYQVRDICQETMLQEV IPEQKRIGIMAAKNAILTPWSGVTYSIMGLVADAAGAKIAFIAAAALYIMTFLIALAQ PRLVHYRRENRVQ*" /label="yjbB CDS" gene 1175128..1176345 /gene="yjbB" /locus_tag="BSU_11480" /old_locus_tag="BSU11480" /label="yjbB gene" promotor_-35 1176398..1176407 /Source="Nicolas_upshift_promotors" /id="U923" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=114 /SigmaFactorBS="cagctggctccgttttgctgaaaaaaaaaTGAAACCATGgcg gaagttcgcACGTCTTTATAGATGTaaggctgtttaaacaagaagaaatggggtatat c" /listShort="S408, yjbC, S409, spxA, S410" /listLong="S411, mecA" /label="promotor_-35" promotor_-10 1176420..1176435 /Source="Nicolas_upshift_promotors" /id="U923" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=114 /SigmaFactorBS="cagctggctccgttttgctgaaaaaaaaaTGAAACCATGgcg gaagttcgcACGTCTTTATAGATGTaaggctgtttaaacaagaagaaatggggtatat c" /listShort="S408, yjbC, S409, spxA, S410" /listLong="S411, mecA" /label="promotor_-10" S_feature 1176429..1176508 /Source="Nicolas_S_feature" /locus_tag="new_1226858_1226937" /HighExp="Etha, B60, M9-stat, T0.30H, Salt, T3.0H, T1.0H, T4.0H, T2.30H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S408" upshifts 1176429 /Source="Nicolas_upshifts" /id="U923" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=114 /SigmaFactorBS="cagctggctccgttttgctgaaaaaaaaaTGAAACCATGgcg gaagttcgcACGTCTTTATAGATGTaaggctgtttaaacaagaagaaatggggtatat c" /listShort="S408, yjbC, S409, spxA, S410" /listLong="S411, mecA" /label="upshifts" CDS 1176509..1177087 /gene="yjbC" /locus_tag="BSU_11490" /old_locus_tag="BSU11490" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17158660, 17158663, 21815947; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thiol oxidation management factor; putative acetyltransferase" /protein_id="NP_389031.2" /db_xref="EnsemblGenomes-Gn:BSU11490" /db_xref="EnsemblGenomes-Tr:CAB13006" /db_xref="GOA:O31601" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13132" /db_xref="UniProtKB/Swiss-Prot:O31601" /translation="MNWYEKLSEYFPIEEMKSKAHMEALLKERSDIYHKDEGKHHILM FAEFDSFIFVDYLYVSKDARGQGLGGKLIAKLKKKNKPILLEVEPVDEDDTDTEKRLR FYQREHFKHAQSIGYRRRSLATNEVNKMEILYWSPKTESEEEILEAMKQTYENIHTYK DEKWYGESYEKTDEVLEIIDEEKQKNIFDQLS*" /label="yjbC CDS" gene 1176509..1177087 /gene="yjbC" /locus_tag="BSU_11490" /old_locus_tag="BSU11490" /label="yjbC gene" S_feature 1177088..1177202 /Source="Nicolas_S_feature" /locus_tag="new_1227517_1227631" /HighExp="B60, Etha, Salt, T0.30H, M9-stat, LoTm, Gly, T1.0H, B36, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S409" promotor_-10 complement(1177139..1177158) /Source="Nicolas_upshift_promotors" /id="U924" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.507492507492508" /psig="0.622377622377622" /xcortree=51 /SigmaFactorBS="aaaaaggaatctttacaggtattaTACTATAAaaaagtaagt gtgAACAGTATCCTAAGAAAAAAatgtgtcaatccagcaaatttttaatgttcatgat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1177143) /Source="Nicolas_upshifts" /id="U924" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.507492507492508" /psig="0.622377622377622" /xcortree=51 /SigmaFactorBS="aaaaaggaatctttacaggtattaTACTATAAaaaagtaagt gtgAACAGTATCCTAAGAAAAAAatgtgtcaatccagcaaatttttaatgttcatgat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1177172..1177179) /Source="Nicolas_upshift_promotors" /id="U924" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.507492507492508" /psig="0.622377622377622" /xcortree=51 /SigmaFactorBS="aaaaaggaatctttacaggtattaTACTATAAaaaagtaagt gtgAACAGTATCCTAAGAAAAAAatgtgtcaatccagcaaatttttaatgttcatgat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 1177205..1177218 /Source="Nicolas_upshift_promotors" /id="U925" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.815184815184815" /psig="0.973026973026973" /xcortree=1536 /SigmaFactorBS="cttaggatactgttcacacttacttttttatagtataatacc tgtaaagattccttttttAGAGTAATTTCAATttaagaataaaatagatgttcatcct a" /listShort="spxA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1177205 /Source="Nicolas_upshifts" /id="U925" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.815184815184815" /psig="0.973026973026973" /xcortree=1536 /SigmaFactorBS="cttaggatactgttcacacttacttttttatagtataatacc tgtaaagattccttttttAGAGTAATTTCAATttaagaataaaatagatgttcatcct a" /listShort="spxA" /GFF_Attribute="listLong" /label="upshifts" CDS 1177268..1177663 /gene="spxA" /locus_tag="BSU_11500" /old_locus_tag="BSU11500" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12642660, 14597697, 15659166, 16249335, 16740936, 18662407, 22307755, 23894131, 28484046, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12642660, 14597697, 15659166, 16249335, 16740936, 18662407, 22307755, 23894131, 28484046, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="redox-sensitive regulator" /protein_id="NP_389032.1" /db_xref="EnsemblGenomes-Gn:BSU11500" /db_xref="EnsemblGenomes-Tr:CAB13007" /db_xref="GOA:O31602" /db_xref="InterPro:IPR006504" /db_xref="InterPro:IPR006660" /db_xref="InterPro:IPR023731" /db_xref="InterPro:IPR036249" /db_xref="PDB:1Z3E" /db_xref="PDB:3GFK" /db_xref="PDB:3IHQ" /db_xref="SubtiList:BG13133" /db_xref="UniProtKB/Swiss-Prot:O31602" /translation="MVTLYTSPSCTSCRKARAWLEEHEIPFVERNIFSEPLSIDEIKQ ILRMTEDGTDEIISTRSKVFQKLNVNVESMPLQDLYRLINEHPGLLRRPIIIDEKRLQ VGYNEDEIRRFLPRKVRSFQLREAQRLAN*" /label="spxA CDS" gene 1177268..1177663 /gene="spxA" /locus_tag="BSU_11500" /old_locus_tag="BSU11500" /label="spxA gene" promotor_no_box complement(1177499..1177599) /Source="Nicolas_upshift_promotors" /id="U926" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig="0.000999000999001" /xcortree=57 /SigmaFactorBS="ctgatttcgtcttcgttatatccgacctgcaaacgtttttcg tcaatgatgatcggacggcgaagcaaacctggatgctcgttgatcaagcggtacaaat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1177539) /Source="Nicolas_upshifts" /id="U926" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig="0.000999000999001" /xcortree=57 /SigmaFactorBS="ctgatttcgtcttcgttatatccgacctgcaaacgtttttcg tcaatgatgatcggacggcgaagcaaacctggatgctcgttgatcaagcggtacaaat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1177661 /Source="Nicolas_upshifts" /id="D625" /incds=0 /nref=263 /ntot=269 /MaxReadThrough="4.34531" /MaxDrop="8.0579" /score="7.42972561" /energy="-8.8" /TU="U923" /idTUdmin="U925" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1177706..1178495 /Source="Nicolas_S_feature" /locus_tag="new_1228135_1228924" /HighExp="B60, B36, Etha, M9-stat, Salt, H2O2, Paraq, Cold, G180, G135" /AntisenseName="yjbE" /AntisenseCor="-0.18634010398760401" /AntisenseRegPval="-2.7" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S410" CDS complement(1177706..1178362) /gene="yjbE" /locus_tag="BSU_11510" /old_locus_tag="BSU11510" /function="16.8: Protect" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein of unknown function" /protein_id="NP_389033.1" /db_xref="EnsemblGenomes-Gn:BSU11510" /db_xref="EnsemblGenomes-Tr:CAB13008" /db_xref="GOA:O31603" /db_xref="InterPro:IPR005496" /db_xref="InterPro:IPR022301" /db_xref="SubtiList:BG13134" /db_xref="UniProtKB/Swiss-Prot:O31603" /translation="MEHDYLISLLVIVGIDLILGGDNAVVIAMASRHLPDKQRQQAII LGTFIAVAMRIGLTSAAVYLLNIPFLQCAGGIFLLYLGYQLLIEKKDTKHIKSSTSLW RAIRTIVLADLFMSLDNVIAVAGASHGEFSLVVIGLCVSVPVIIWGSKLIHIALEKIP LLIYAGSGLLAYTGGEMIVRDKKLSLFMAQHGTVETLLPILTVAFVILASIYYQQVEK *" /label="yjbE CDS" gene complement(1177706..1178362) /gene="yjbE" /locus_tag="BSU_11510" /old_locus_tag="BSU11510" /label="yjbE gene" promotor_-10 complement(1178392..1178410) /Source="Nicolas_upshift_promotors" /id="U927" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=987 /SigmaFactorBS="cacctttgcctaaaaaacggcagatcaggcggctgatATCAT AaaatatgacctgtcTCATATAGTAGTAGTACAAgcgaaggactgaaagcgaggtgcc g" /listShort="yjbE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1178407) /Source="Nicolas_upshifts" /id="U927" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=987 /SigmaFactorBS="cacctttgcctaaaaaacggcagatcaggcggctgatATCAT AaaatatgacctgtcTCATATAGTAGTAGTACAAgcgaaggactgaaagcgaggtgcc g" /listShort="yjbE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1178425..1178430) /Source="Nicolas_upshift_promotors" /id="U927" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=987 /SigmaFactorBS="cacctttgcctaaaaaacggcagatcaggcggctgatATCAT AaaatatgacctgtcTCATATAGTAGTAGTACAAgcgaaggactgaaagcgaggtgcc g" /listShort="yjbE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1178468..1178475 /Source="Nicolas_upshift_promotors" /id="U928" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.845154845154845" /psig="0.998001998001998" /xcortree=622 /SigmaFactorBS="cgcctgatctgccgttttttaggcaaaggtgCATTTTTAttt cttttgtgacTGTTTTATCATAAAATAGAAatacaaaggaattcacactggccttggt t" /listShort="S411, mecA, S412, S413, coiA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1178489..1178508 /Source="Nicolas_upshift_promotors" /id="U928" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.845154845154845" /psig="0.998001998001998" /xcortree=622 /SigmaFactorBS="cgcctgatctgccgttttttaggcaaaggtgCATTTTTAttt cttttgtgacTGTTTTATCATAAAATAGAAatacaaaggaattcacactggccttggt t" /listShort="S411, mecA, S412, S413, coiA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1178497..1178638 /Source="Nicolas_S_feature" /locus_tag="new_1228926_1229067" /HighExp="B60, Diami, Etha, dia5, LPhT, M9-stat, T5.0H, T3.0H, dia15, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="SigWXY" /TUlongPSig=1 /label="S411" upshifts 1178497 /Source="Nicolas_upshifts" /id="U928" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.845154845154845" /psig="0.998001998001998" /xcortree=622 /SigmaFactorBS="cgcctgatctgccgttttttaggcaaaggtgCATTTTTAttt cttttgtgacTGTTTTATCATAAAATAGAAatacaaaggaattcacactggccttggt t" /listShort="S411, mecA, S412, S413, coiA" /GFF_Attribute="listLong" /label="upshifts" CDS 1178532..1178672 /locus_tag="BSU_11515" /old_locus_tag="BSU11515" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_009513949.1" /translation="MVKVKMWTEWVKCSKVQLIGSLDVPSTSYIEGKVGKWKLKELTS IQ*" /label="conserved hypothetical protein CDS" gene 1178532..1178672 /locus_tag="BSU_11515" /old_locus_tag="BSU11515" /label="gene" CDS 1178639..1179295 /gene="mecA" /locus_tag="BSU_11520" /old_locus_tag="BSU11520" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10361283, 10447896, 16525504, 19801546, 21435029, 23595989" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10361283, 10447896, 16525504, 19801546, 21435029, 23595989; Product type f : factor" /codon_start=1 /transl_table=11 /product="adaptor protein controlling oligomerization of the AAA+ protein ClpC" /protein_id="NP_389034.1" /db_xref="EnsemblGenomes-Gn:BSU11520" /db_xref="EnsemblGenomes-Tr:CAB13009" /db_xref="GOA:P37958" /db_xref="InterPro:IPR008681" /db_xref="PDB:2Y1R" /db_xref="PDB:3J3R" /db_xref="PDB:3J3S" /db_xref="PDB:3J3T" /db_xref="PDB:3J3U" /db_xref="PDB:3JTP" /db_xref="PDB:3PXG" /db_xref="PDB:3PXI" /db_xref="SubtiList:BG10680" /db_xref="UniProtKB/Swiss-Prot:P37958" /translation="MEIERINEHTVKFYMSYGDIEDRGFDREEIWYNRERSEELFWEV MDEVHEEEEFAVEGPLWIQVQALDKGLEIIVTKAQLSKDGQKLELPIPEDKKQEPASE DLDALLDDFQKEEQAVNQEEKEQKLQFVLRFGDFEDVISLSKLNVNGSKTTLYSFENR YYLYVDFCNMTDEEVENQLSILLEYATESSISIHRLEEYGKLIISEHALETIKKHFAS *" /label="mecA CDS" gene 1178639..1179295 /gene="mecA" /locus_tag="BSU_11520" /old_locus_tag="BSU11520" /label="mecA gene" downshifts 1179285 /Source="Nicolas_upshifts" /id="D626" /incds=0 /nref=120 /ntot=308 /MaxReadThrough="5.41786" /MaxDrop="7.67172" /score="32.2431225" /energy="-11.8" /TU="U928" /idTUdmin="U928" /TUdmin="-774" /isTUend="FALSE" /label="downshifts" CDS complement(1179290..1179412) /locus_tag="BSU_11525" /old_locus_tag="BSU11525" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_009513950.1" /translation="MINSCSLYFLLVYMFLIFHISKMAFSCIKKTDFRKEIGLL*" /label="conserved hypothetical protein CDS" gene complement(1179290..1179412) /locus_tag="BSU_11525" /old_locus_tag="BSU11525" /label="gene" S_feature 1179330..1179419 /Source="Nicolas_S_feature" /locus_tag="new_1229759_1229848" /HighExp="Etha, M9-stat, B60, dia15, T0.30H, Diami, C30, H2O2, dia5, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S412" promotor_-35 1179398..1179406 /Source="Nicolas_upshift_promotors" /id="U929" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=2965 /SigmaFactorBS="aaatcaaaaacatatagacaagcagaaaatacagcgaACAGG AGTTgatcatctttTCCAGAAAGTATACTTCATctggaaaggagagatgacaattgtt t" /listShort="S413, coiA, pepF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1179417..1179435 /Source="Nicolas_upshift_promotors" /id="U929" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=2965 /SigmaFactorBS="aaatcaaaaacatatagacaagcagaaaatacagcgaACAGG AGTTgatcatctttTCCAGAAAGTATACTTCATctggaaaggagagatgacaattgtt t" /listShort="S413, coiA, pepF" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1179421..1179485 /Source="Nicolas_S_feature" /locus_tag="new_1229850_1229914" /HighExp="Etha, G/S, GM 150, T-4.40H, S2, T-2.40H, Pyr, C90, M9-tran, T-3.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH, SigA" /TUshortPSig="0.876, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S413" upshifts 1179421 /Source="Nicolas_upshifts" /id="U929" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=2965 /SigmaFactorBS="aaatcaaaaacatatagacaagcagaaaatacagcgaACAGG AGTTgatcatctttTCCAGAAAGTATACTTCATctggaaaggagagatgacaattgtt t" /listShort="S413, coiA, pepF" /GFF_Attribute="listLong" /label="upshifts" CDS 1179486..1180607 /gene="coiA" /locus_tag="BSU_11530" /old_locus_tag="BSU11530" /function="16.1: Circulate" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10438773, 17630974, 23046409, 26880300" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10438773, 17630974, 23046409, 26880300; Product type s: structure" /codon_start=1 /transl_table=11 /product="protein involved in establishment of DNA transport in competence" /protein_id="NP_389035.1" /db_xref="EnsemblGenomes-Gn:BSU11530" /db_xref="EnsemblGenomes-Tr:CAB13010" /db_xref="GOA:O31604" /db_xref="InterPro:IPR010330" /db_xref="InterPro:IPR021176" /db_xref="SubtiList:BG13135" /db_xref="UniProtKB/Swiss-Prot:O31604" /translation="MFHLLGAQQNQKLKRRRFFCPVCGGELAVKLGLQKAPHFAHKQN KSCAIDIEPESAYHLEGKRQLYVWLKTQRASPILEPYIRTINQRPDVMARIKEHMLAV EYQCATIAPDVFQKRTEGFKQEGIIPQWIMGYSRLKRTASSFYQLSTFHWQFINASPY RELICYCPERRSFLRLSHIIPFYTNHSYSSVQTIPIHRAGAGDLFFTEPKPSIQYSGW TKAIHRFRHKPHRFNSKETNRLRLLFYEKRQTPFSFLPTEVFVPVRKGAVFKSPVFVW QGFLYLFMTDLGGKRAPIRFSAVLQQCKLHIHNKNIALRSECSEECLSEAVKQYIDFL CKKGFLRETQKEVYVLNQPAGGIHSMQDLIERDRSCFIE*" /label="coiA CDS" gene 1179486..1180607 /gene="coiA" /locus_tag="BSU_11530" /old_locus_tag="BSU11530" /label="coiA gene" promotor_-35 1180261..1180267 /Source="Nicolas_upshift_promotors" /id="U930" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=156 /SigmaFactorBS="atgagaaacgacagacgcctttttcttttctgccgactgaag TGTTTGTtcctgttagaaaagGGGCAGTTTTTAAGAGTCCggtttttgtgtggcaggg g" /listShort="pepF" /listLong="S414, S415" /label="promotor_-35" upshifts 1180279 /Source="Nicolas_upshifts" /id="U930" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=156 /SigmaFactorBS="atgagaaacgacagacgcctttttcttttctgccgactgaag TGTTTGTtcctgttagaaaagGGGCAGTTTTTAAGAGTCCggtttttgtgtggcaggg g" /listShort="pepF" /listLong="S414, S415" /label="upshifts" promotor_-10 1180282..1180300 /Source="Nicolas_upshift_promotors" /id="U930" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=156 /SigmaFactorBS="atgagaaacgacagacgcctttttcttttctgccgactgaag TGTTTGTtcctgttagaaaagGGGCAGTTTTTAAGAGTCCggtttttgtgtggcaggg g" /listShort="pepF" /listLong="S414, S415" /label="promotor_-10" promotor_-35 1180493..1180501 /Source="Nicolas_upshift_promotors" /id="U931" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=546 /SigmaFactorBS="agcggttaaacagtatattgattttttgtgcaaGAAGGGATT tttaagggagaCTCAGAAAGAAGTATATGTgctgaatcagcctgcaggaggcatacac t" /listShort="pepF" /listLong="S414, S415" /label="promotor_-35" promotor_-10 1180513..1180531 /Source="Nicolas_upshift_promotors" /id="U931" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=546 /SigmaFactorBS="agcggttaaacagtatattgattttttgtgcaaGAAGGGATT tttaagggagaCTCAGAAAGAAGTATATGTgctgaatcagcctgcaggaggcatacac t" /listShort="pepF" /listLong="S414, S415" /label="promotor_-10" upshifts 1180520 /Source="Nicolas_upshifts" /id="U931" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=546 /SigmaFactorBS="agcggttaaacagtatattgattttttgtgcaaGAAGGGATT tttaagggagaCTCAGAAAGAAGTATATGTgctgaatcagcctgcaggaggcatacac t" /listShort="pepF" /listLong="S414, S415" /label="upshifts" promotor_-35 1180601..1180607 /Source="Nicolas_upshift_promotors" /id="U932" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=911 /SigmaFactorBS="tctcatagaaagagaccgcagctgttttatAGAATGAgtttg tcttatttgGCTCACCCTAAGacaaaggtggtgggcaggctgtgaaaggcacaaaagg a" /listShort="pepF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1180622..1180633 /Source="Nicolas_upshift_promotors" /id="U932" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=911 /SigmaFactorBS="tctcatagaaagagaccgcagctgttttatAGAATGAgtttg tcttatttgGCTCACCCTAAGacaaaggtggtgggcaggctgtgaaaggcacaaaagg a" /listShort="pepF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1180631 /Source="Nicolas_upshifts" /id="U932" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=911 /SigmaFactorBS="tctcatagaaagagaccgcagctgttttatAGAATGAgtttg tcttatttgGCTCACCCTAAGacaaaggtggtgggcaggctgtgaaaggcacaaaagg a" /listShort="pepF" /GFF_Attribute="listLong" /label="upshifts" CDS 1180654..1182666 /gene="pepF" /locus_tag="BSU_11540" /old_locus_tag="BSU11540" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11741842" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11741842; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oligoendopeptidase F" /protein_id="NP_389036.2" /db_xref="EnsemblGenomes-Gn:BSU11540" /db_xref="EnsemblGenomes-Tr:CAB13011" /db_xref="GOA:O31605" /db_xref="InterPro:IPR001567" /db_xref="InterPro:IPR004438" /db_xref="InterPro:IPR013647" /db_xref="SubtiList:BG13136" /db_xref="UniProtKB/Swiss-Prot:O31605" /translation="MKGTKGKVFRVFTAFLAFVLFITAYDLTKGSEKPEDIHNTSLLR NSCFFNWLESKKTRGITMAEEKKANQLPDRSEVKAEDTWRLEDIFPSDEAWNKEFQAV KELIPNLSKYKGKLADSADHLYEALTYQDKVMERLGRLYTYAHMRSDQDTGNSFYQGL NDKAGNLYTQAASATAYLVPEILSIEEDKLQQFILEKEELKLYSHAIEEITKERPHVL SEKEEALLAEASEVLGSSSNTFSVLNNADITFPSIKDEDGNEKQITHGNFINFLESEN REVRKNAFDAVYKTYGQYKNTMATTLSGTVKKDNFYARVKKYKSAREAALSNNSIPEE VYDNLVKTINKHLPLLHRYIALRKKVLELDEVHIYDLYTPLVKDAGMKVTYEEAKDYM LKGLAPLGEEYASILKEGLENRWVDVYENKGKRNGAYSSGAYGTNPYILMNWHNNVNN LFTLVHEFGHSVHSYYTRKHQPYPYGNYSIFVAEVASTTNEALLGEYLLNNLEDEKQR LYILNHMLEGFRGTVFRQTMFAEFEHLIHTKAQEGEPLTPELLTNVYYDLNKKYFGDG MVIDKEIGLEWSRIPHFYYNYYVYQYATGYSAAQALSSQILKEGKPAVDRYIDFLKAG SSQYPIDVLKKAGVDMTSPEPIEAACKMFEEKLDEMEELLMKVKQS*" /label="pepF CDS" gene 1180654..1182666 /gene="pepF" /locus_tag="BSU_11540" /old_locus_tag="BSU11540" /label="pepF gene" promotor_-35 1180729..1180736 /Source="Nicolas_upshift_promotors" /id="U933" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.802197802197802" /psig="0.926073926073926" /xcortree=3181 /SigmaFactorBS="cattcgttctcttcattactgcatatGATTTGACaaaaggca gtgaaaAACCGGAAGATATTCACAACacaagtttattgagaaacagctgttttttcaa t" /listShort="S414" /listLong="S415" /label="promotor_-35" promotor_-10 1180751..1180770 /Source="Nicolas_upshift_promotors" /id="U933" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.802197802197802" /psig="0.926073926073926" /xcortree=3181 /SigmaFactorBS="cattcgttctcttcattactgcatatGATTTGACaaaaggca gtgaaaAACCGGAAGATATTCACAACacaagtttattgagaaacagctgttttttcaa t" /listShort="S414" /listLong="S415" /label="promotor_-10" upshifts 1180763 /Source="Nicolas_upshifts" /id="U933" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.802197802197802" /psig="0.926073926073926" /xcortree=3181 /SigmaFactorBS="cattcgttctcttcattactgcatatGATTTGACaaaaggca gtgaaaAACCGGAAGATATTCACAACacaagtttattgagaaacagctgttttttcaa t" /listShort="S414" /listLong="S415" /label="upshifts" downshifts 1182613 /Source="Nicolas_upshifts" /id="D627" /incds=0 /nref=98 /ntot=339 /MaxReadThrough="4.70576" /MaxDrop="5.74441" /score="19.0969124" /energy="-15.2" /TU="U933" /idTUdmin="U931" /TUdmin=2 /isTUend="TRUE" /label="downshifts" S_feature 1182667..1182968 /Source="Nicolas_S_feature" /locus_tag="new_1233096_1233397" /HighExp="Etha, dia15, Diami, B60, M9-stat, S8, M0t90, dia5, B36, T0.30H" /AntisenseName="yizD" /AntisenseCor="-1.29003203536192E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.926" /TUlongSig="SigH, SigB" /TUlongPSig="0.999, 0.999" /label="S414" CDS complement(1182704..1182871) /gene="yizD" /locus_tag="BSU_11549" /old_locus_tag="BSU11549" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097703.1" /db_xref="EnsemblGenomes-Gn:BSU11549" /db_xref="EnsemblGenomes-Tr:CAX52593" /db_xref="GOA:C0H3Y6" /db_xref="UniProtKB/Swiss-Prot:C0H3Y6" /translation="MMSTLISIVCIAVFFCLNILGMMHMLPLYITSPLLFLSILFTLY RLNHRKTFKGF*" /label="yizD CDS" gene complement(1182704..1182871) /gene="yizD" /locus_tag="BSU_11549" /old_locus_tag="BSU11549" /label="yizD gene" downshifts complement(1182717) /Source="Nicolas_upshifts" /id="D628" /incds=0 /nref=8 /ntot=61 /MaxReadThrough="1.527" /MaxDrop="5.54041" /score="-4.56163992" /energy="-15.2" /TU="NA" /idTUdmin="U934" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1182891..1182909) /Source="Nicolas_upshift_promotors" /id="U934" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1166 /SigmaFactorBS="acaacctctatgcttaatgttcatatttttgtcacaaAACAT AacgaagtgcattcacTCATATCCTTATAAGGAAAaaggacgaggaggaccgccatga t" /listShort="yizD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1182907) /Source="Nicolas_upshifts" /id="U934" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1166 /SigmaFactorBS="acaacctctatgcttaatgttcatatttttgtcacaaAACAT AacgaagtgcattcacTCATATCCTTATAAGGAAAaaggacgaggaggaccgccatga t" /listShort="yizD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1182925..1182930) /Source="Nicolas_upshift_promotors" /id="U934" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1166 /SigmaFactorBS="acaacctctatgcttaatgttcatatttttgtcacaaAACAT AacgaagtgcattcacTCATATCCTTATAAGGAAAaaggacgaggaggaccgccatga t" /listShort="yizD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1182961..1182968 /Source="Nicolas_upshift_promotors" /id="U935" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.583416583416583" /psig="0.883116883116883" /xcortree=90 /SigmaFactorBS="gtgaatgcacttcgttatgttttgtgacaaaaatatgaacat taagcatagAGGTTGTCaaaagtcgacatctTTTGTTATCATAAGGATGTGaaattga t" /listShort="S415" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1182970..1183095 /Source="Nicolas_S_feature" /locus_tag="new_1233399_1233524" /HighExp="B36, T-1.10H, nit, T-0.40H, M9-tran, LoTm, Pyr, Etha, Salt, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.883" /TUlongSig="SigA, SigH, SigB" /TUlongPSig="0.926, 0.999, 0.999" /label="S415" upshifts 1182970 /Source="Nicolas_upshifts" /id="U935" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.583416583416583" /psig="0.883116883116883" /xcortree=90 /SigmaFactorBS="gtgaatgcacttcgttatgttttgtgacaaaaatatgaacat taagcatagAGGTTGTCaaaagtcgacatctTTTGTTATCATAAGGATGTGaaattga t" /listShort="S415" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 1182976..1183114 /gene="roxS" /locus_tag="BSU_misc_RNA_67" /product="small regulatory RNA (NO regulated)" /experiment="publication(s) with functional evidences, PMID:19682248, 19786493, 20511587, 20525796, 25643072, 28436820" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19682248, 19786493, 20511587, 20525796, 25643072, 28436820; Product type n : RNA" /label="roxS RNA" gene 1182976..1183114 /gene="roxS" /locus_tag="BSU_misc_RNA_67" /label="roxS gene" promotor_-10 1182983..1183002 /Source="Nicolas_upshift_promotors" /id="U935" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.583416583416583" /psig="0.883116883116883" /xcortree=90 /SigmaFactorBS="gtgaatgcacttcgttatgttttgtgacaaaaatatgaacat taagcatagAGGTTGTCaaaagtcgacatctTTTGTTATCATAAGGATGTGaaattga t" /listShort="S415" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 1183052 /Source="Nicolas_upshifts" /id="D629" /incds=0 /nref=96 /ntot=135 /MaxReadThrough="3.50613" /MaxDrop="9.07209" /score="5.30186633" /energy="-11.6" /TU="U935" /idTUdmin="U933" /TUdmin=89 /isTUend="FALSE" /label="downshifts" CDS complement(1183185..1184084) /gene="spxH" /locus_tag="BSU_11550" /old_locus_tag="BSU11550" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:17293416, 17908206, 21378193, 22194450, 24942655, 25353645, 27191337, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17293416, 17908206, 21378193, 22194450, 24942655, 25353645, 27191337, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="thiol management effector of SpxA degradation" /protein_id="NP_389037.2" /db_xref="EnsemblGenomes-Gn:BSU11550" /db_xref="EnsemblGenomes-Tr:CAB13012" /db_xref="GOA:O31606" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG13137" /db_xref="UniProtKB/Swiss-Prot:O31606" /translation="MTNYQHELYFAHCHGHPKKPLEIYMFVDPLCPECWSLEPVIKKL KIRYGRFFTLRIIASASLTALNKKRKKHLLAEAWEKIASRSGMSCDGNVWFEQDQPLS SPYMAALAFKAAELQGRKAGMQFLRNMQESLFVSKKNITDENVLLEIAENTSLDLEEF KKDLHSQSAVKALQCDMKIAAEMDVSVNPTLTFFNTQHEDEGLKVPGSYSYDVYEEIL FEMLGDEPKPSETPPLECFIEYFRFVASKEIALVYDLSLEEVEKEMKKLAFAKKVAKV EAKHGMFWKSLSTYSDEYQSCEK*" /label="spxH CDS" gene complement(1183185..1184084) /gene="spxH" /locus_tag="BSU_11550" /old_locus_tag="BSU11550" /label="spxH gene" downshifts complement(1183216) /Source="Nicolas_upshifts" /id="D630" /incds=0 /nref=185 /ntot=251 /MaxReadThrough="3.70729" /MaxDrop="5.65601" /score="17.9327625" /energy="-13.3" /TU="U937" /idTUdmin="U937" /TUdmin="-89" /isTUend="FALSE" /label="downshifts" promotor_-35 1183420..1183425 /Source="Nicolas_upshift_promotors" /id="U936" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1111 /SigmaFactorBS="ataaaacattctaaaggcggtgtttccgacggcttcggctcg tcgccaAGCATCtcaaataaaatttctTCATATACATCATATGAGTagctgccaggaa c" /listShort="S416" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1183432 /Source="Nicolas_upshifts" /id="U936" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1111 /SigmaFactorBS="ataaaacattctaaaggcggtgtttccgacggcttcggctcg tcgccaAGCATCtcaaataaaatttctTCATATACATCATATGAGTagctgccaggaa c" /listShort="S416" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1183441..1183459 /Source="Nicolas_upshift_promotors" /id="U936" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1111 /SigmaFactorBS="ataaaacattctaaaggcggtgtttccgacggcttcggctcg tcgccaAGCATCtcaaataaaatttctTCATATACATCATATGAGTagctgccaggaa c" /listShort="S416" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1183448..1185349 /Source="Nicolas_S_feature" /locus_tag="new_1233877_1235778" /HighExp="S6, S4, S5, S8, S3, S7, BT, B36, C30, T5.0H" /AntisenseName="yjbH" /AntisenseCor="-0.61019541931037402" /AntisenseRegPval="-28.1" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S416" CDS complement(1184081..1184479) /gene="yjbI" /locus_tag="BSU_11560" /old_locus_tag="BSU11560" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15866723, 17293416; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thiol management oxidoreductase component" /protein_id="NP_389038.1" /db_xref="EnsemblGenomes-Gn:BSU11560" /db_xref="EnsemblGenomes-Tr:CAB13013" /db_xref="GOA:O31607" /db_xref="InterPro:IPR001486" /db_xref="InterPro:IPR009050" /db_xref="InterPro:IPR019795" /db_xref="PDB:1UX8" /db_xref="SubtiList:BG13138" /db_xref="UniProtKB/Swiss-Prot:O31607" /translation="MGQSFNAPYEAIGEELLSQLVDTFYERVASHPLLKPIFPSDLTE TARKQKQFLTQYLGGPPLYTEEHGHPMLRARHLPFPITNERADAWLSCMKDAMDHVGL EGEIREFLFGRLELTARHMVNQTEAEDRSS*" /label="yjbI CDS" gene complement(1184081..1184479) /gene="yjbI" /locus_tag="BSU_11560" /old_locus_tag="BSU11560" /label="yjbI gene" S_feature complement(1184480..1184659) /Source="Nicolas_S_feature" /locus_tag="new_1234909_1235088_c" /HighExp="Diami, dia5, dia15, Etha, H2O2, C90, LoTm, Heat, Salt, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigD, SigA" /TUlongPSig="1, 0.999" /label="S417" promotor_-10 complement(1184651..1184670) /Source="Nicolas_upshift_promotors" /id="U937" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=1912 /SigmaFactorBS="tccctctggtttttttgcgaagtgaaatctTACGCATTcctg atttttaTGTGATATGATATGAAATACaaaccccggctgtcagccgaaatgagtcatc a" /listShort="S417, yjbI, yjbH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1184659) /Source="Nicolas_upshifts" /id="U937" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=1912 /SigmaFactorBS="tccctctggtttttttgcgaagtgaaatctTACGCATTcctg atttttaTGTGATATGATATGAAATACaaaccccggctgtcagccgaaatgagtcatc a" /listShort="S417, yjbI, yjbH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1184682..1184689) /Source="Nicolas_upshift_promotors" /id="U937" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=1912 /SigmaFactorBS="tccctctggtttttttgcgaagtgaaatctTACGCATTcctg atttttaTGTGATATGATATGAAATACaaaccccggctgtcagccgaaatgagtcatc a" /listShort="S417, yjbI, yjbH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1184734..1185279) /gene="cwlQ" /locus_tag="BSU_11570" /old_locus_tag="BSU11570" /EC_number="3.2.1.-" /EC_number="3.2.1.17" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:20609359" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20609359; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional muramidase and murein lytic transglycosylase" /protein_id="NP_389039.1" /db_xref="EnsemblGenomes-Gn:BSU11570" /db_xref="EnsemblGenomes-Tr:CAB13014" /db_xref="GOA:O31608" /db_xref="InterPro:IPR000189" /db_xref="InterPro:IPR008258" /db_xref="InterPro:IPR023346" /db_xref="SubtiList:BG13139" /db_xref="UniProtKB/Swiss-Prot:O31608" /translation="MLNSANTTAPSLLSAYGLNSYTSSNSGSVTKAAESTETAVADSA SNKHEANQIRSGDFSIDSAIKKAADKYGVDEKLIRAVIKQESGFNAKAVSGAGAMGLM QLMPSTASSLGVSNPLDPQQNVEGGTKYLKQMLDKYDGNVSMALAAYNAGPGNVDRYG GIPPFQETQNYVKKITSVYYA*" /label="cwlQ CDS" gene complement(1184734..1185279) /gene="cwlQ" /locus_tag="BSU_11570" /old_locus_tag="BSU11570" /label="cwlQ gene" downshifts complement(1184758) /Source="Nicolas_upshifts" /id="D631" /incds=0 /nref=101 /ntot=222 /MaxReadThrough="4.1014" /MaxDrop="5.00847" /score="6.97790581" /energy="-9.1" /TU="U938,U939" /idTUdmin="U938" /TUdmin="-90" /isTUend="FALSE" /label="downshifts" S_feature complement(1185280..1185482) /Source="Nicolas_S_feature" /locus_tag="new_1235709_1235911_c" /HighExp="T0.30H, Gly, C90, GM 10, GM 45, M0t90, Lbstat, C30, Lbtran, GM 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S418" CDS complement(1185483..1186055) /gene="yjbK" /locus_tag="BSU_11580" /old_locus_tag="BSU11580" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9642185, 12456267, 16905149, 20509597, 26904951, 27881678; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="putative RNA/thiamine triphosphatase" /protein_id="NP_389040.1" /db_xref="EnsemblGenomes-Gn:BSU11580" /db_xref="EnsemblGenomes-Tr:CAB13015" /db_xref="GOA:O31609" /db_xref="InterPro:IPR009195" /db_xref="InterPro:IPR023577" /db_xref="InterPro:IPR033469" /db_xref="SubtiList:BG13140" /db_xref="UniProtKB/Swiss-Prot:O31609" /translation="MSQEIEIEFKNMLTKQEFKNIASALQLTEKDFTDQKNHYFDTDS FALKQKHAALRIRRKNGKYVLTLKEPADVGLLETHQQLSEVSDLAGFSVPEGPVKDQL HKLQIDTDAIQYFGSLATNRAEKETEKGLIVLDHSRYLNKEDYEIEFEAADWHEGRQA FEKLLQQFSIPQRETKNKILRFYEEKRKSI*" /label="yjbK CDS" gene complement(1185483..1186055) /gene="yjbK" /locus_tag="BSU_11580" /old_locus_tag="BSU11580" /label="yjbK gene" promotor_-10 complement(1185628..1185646) /Source="Nicolas_upshift_promotors" /id="U938" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2803 /SigmaFactorBS="caaaccgtgcggaaaaagaaacagaaaaaggCTTAATAGttt tagaccacaGCCGATATTTAAATAAAGAggactatgaaattgaatttgaggcggcgga t" /listShort="S418, yjbJ" /listLong="S417, yjbI, yjbH" /label="promotor_-10" upshifts complement(1185637) /Source="Nicolas_upshifts" /id="U938" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2803 /SigmaFactorBS="caaaccgtgcggaaaaagaaacagaaaaaggCTTAATAGttt tagaccacaGCCGATATTTAAATAAAGAggactatgaaattgaatttgaggcggcgga t" /listShort="S418, yjbJ" /listLong="S417, yjbI, yjbH" /label="upshifts" promotor_-35 complement(1185659..1185666) /Source="Nicolas_upshift_promotors" /id="U938" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2803 /SigmaFactorBS="caaaccgtgcggaaaaagaaacagaaaaaggCTTAATAGttt tagaccacaGCCGATATTTAAATAAAGAggactatgaaattgaatttgaggcggcgga t" /listShort="S418, yjbJ" /listLong="S417, yjbI, yjbH" /label="promotor_-35" promotor_-10 complement(1186084..1186103) /Source="Nicolas_upshift_promotors" /id="U939" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.782217782217782" /psig="0.999000999001" /xcortree=2255 /SigmaFactorBS="acaaagtacagattcattttatcatatcgagctcgaTATTGA TAaacctaacatctaaAGAGATAATAGTAAAAATAAgatttacagggcggaaaggaag a" /listShort="yjbK, S418, yjbJ" /listLong="S417, yjbI, yjbH" /label="promotor_-10" upshifts complement(1186101) /Source="Nicolas_upshifts" /id="U939" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.782217782217782" /psig="0.999000999001" /xcortree=2255 /SigmaFactorBS="acaaagtacagattcattttatcatatcgagctcgaTATTGA TAaacctaacatctaaAGAGATAATAGTAAAAATAAgatttacagggcggaaaggaag a" /listShort="yjbK, S418, yjbJ" /listLong="S417, yjbI, yjbH" /label="upshifts" promotor_-35 1186117..1186120 /Source="Nicolas_upshift_promotors" /id="U940" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.534465534465534" /psig="0.994005994005994" /xcortree=2570 /SigmaFactorBS="ccctgtaaatcttatttttactattatctctttagatgttag gtTTATcaatatcgagctcgaTATGATAAAATGAATCTGTActttgtttaaaaaagga g" /listShort="yjbL, yjbM, ppnKA, yjbO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(1186118..1186125) /Source="Nicolas_upshift_promotors" /id="U939" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.782217782217782" /psig="0.999000999001" /xcortree=2255 /SigmaFactorBS="acaaagtacagattcattttatcatatcgagctcgaTATTGA TAaacctaacatctaaAGAGATAATAGTAAAAATAAgatttacagggcggaaaggaag a" /listShort="yjbK, S418, yjbJ" /listLong="S417, yjbI, yjbH" /label="promotor_-35" upshifts 1186133 /Source="Nicolas_upshifts" /id="U940" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.534465534465534" /psig="0.994005994005994" /xcortree=2570 /SigmaFactorBS="ccctgtaaatcttatttttactattatctctttagatgttag gtTTATcaatatcgagctcgaTATGATAAAATGAATCTGTActttgtttaaaaaagga g" /listShort="yjbL, yjbM, ppnKA, yjbO" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1186136..1186155 /Source="Nicolas_upshift_promotors" /id="U940" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.534465534465534" /psig="0.994005994005994" /xcortree=2570 /SigmaFactorBS="ccctgtaaatcttatttttactattatctctttagatgttag gtTTATcaatatcgagctcgaTATGATAAAATGAATCTGTActttgtttaaaaaagga g" /listShort="yjbL, yjbM, ppnKA, yjbO" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1186180..1186548 /gene="yjbL" /locus_tag="BSU_11590" /old_locus_tag="BSU11590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22333191; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389041.1" /db_xref="EnsemblGenomes-Gn:BSU11590" /db_xref="EnsemblGenomes-Tr:CAB13016" /db_xref="InterPro:IPR020908" /db_xref="SubtiList:BG13141" /db_xref="UniProtKB/Swiss-Prot:O31610" /translation="MQNRIEILNATLSDDQLRLACQTEGNEAERKPSGQMLVDSDHFA FVYILELADSFEYVIIKEHVWPELKQAHAQKIPVVLEAGDQTIELAGLHEELEYLLEN IKDNANYGEEMEEKVKRVFL*" /label="yjbL CDS" gene 1186180..1186548 /gene="yjbL" /locus_tag="BSU_11590" /old_locus_tag="BSU11590" /label="yjbL gene" CDS 1186577..1187212 /gene="relP" /locus_tag="BSU_11600" /old_locus_tag="BSU11600" /EC_number="2.7.6.5" /function="16.1: Circulate" /function="16.14: Store" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17714452, 18067544, 19447912, 24163341, 25331430, 26825398" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17714452, 18067544, 19447912, 24163341, 25331430, 26825398; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="(p)ppGpp synthetase" /protein_id="NP_389042.1" /db_xref="EnsemblGenomes-Gn:BSU11600" /db_xref="EnsemblGenomes-Tr:CAB13017" /db_xref="GOA:O31611" /db_xref="InterPro:IPR007685" /db_xref="PDB:5DEC" /db_xref="PDB:5DED" /db_xref="PDB:5F2V" /db_xref="SubtiList:BG13142" /db_xref="UniProtKB/Swiss-Prot:O31611" /translation="MDDKQWERFLVPYRQAVEELKVKLKGIRTLYEYEDDHSPIEFVT GRVKPVASILEKARRKSIPLHEIETMQDIAGLRIMCQFVDDIQIVKEMLFARKDFTVV DQRDYIAEHKESGYRSYHLVVLYPLQTVSGEKHVLVEIQIRTLAMNFWATIEHSLNYK YSGNIPEKVKLRLQRASEAASRLDEEMSEIRGEVQEAQAAFSRKKKGSEQQ*" /label="relP CDS" gene 1186577..1187212 /gene="relP" /locus_tag="BSU_11600" /old_locus_tag="BSU11600" /label="relP gene" CDS 1187231..1188031 /gene="ppnKA" /locus_tag="BSU_11610" /old_locus_tag="BSU11610" /EC_number="2.7.1.23" /function="16.14: Store" /function="16.7: Manage energy" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 12897004, 16233726, 16511117, 18720024, 24048943" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 12897004, 16233726, 16511117, 18720024, 24048943; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="inorganic polyphosphate/ATP-NAD kinase (quinolate activated)" /protein_id="NP_389043.1" /db_xref="EnsemblGenomes-Gn:BSU11610" /db_xref="EnsemblGenomes-Tr:CAB13018" /db_xref="GOA:O31612" /db_xref="InterPro:IPR002504" /db_xref="InterPro:IPR016064" /db_xref="InterPro:IPR017437" /db_xref="InterPro:IPR017438" /db_xref="SubtiList:BG13143" /db_xref="UniProtKB/Swiss-Prot:O31612" /translation="MKFAVSSKGDQVSDTLKSKIQAYLLDFDMELDENEPEIVISVGG DGTLLYAFHRYSDRLDKTAFVGVHTGHLGFYADWVPHEIEKLVLAIAKTPYHTVEYPL LEVIVTYHENEREERYLALNECTIKSIEGSLVADVEIKGQLFETFRGDGLCLSTPSGS TAYNKALGGAIIHPSIRAIQLAEMASINNRVFRTVGSPLLLPSHHDCMIKPRNEVDFQ VTIDHLTLLHKDVKSIRCQVASEKVRFARFRPFPFWKRVQDSFIGKGE*" /label="ppnKA CDS" gene 1187231..1188031 /gene="ppnKA" /locus_tag="BSU_11610" /old_locus_tag="BSU11610" /label="ppnKA gene" CDS 1188094..1188945 /gene="yjbO" /locus_tag="BSU_11620" /old_locus_tag="BSU11620" /EC_number="5.4.99.-" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pseudouridylate synthase" /protein_id="NP_389044.1" /db_xref="EnsemblGenomes-Gn:BSU11620" /db_xref="EnsemblGenomes-Tr:CAB13019" /db_xref="GOA:O31613" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR006145" /db_xref="InterPro:IPR006224" /db_xref="InterPro:IPR006225" /db_xref="InterPro:IPR020103" /db_xref="SubtiList:BG13144" /db_xref="UniProtKB/Swiss-Prot:O31613" /translation="MTVKEYAGELGISKRLLTDIKFGGGDLQINGEHVTVKYVLKEGD LLIVKFPEEQVSETLLAEPVPLDILYEDEHVLVINKQPYVSSIPSREHPSGSIANGII DHYQTTGVRATVHLVTRLDRDTSGIMLVAKHRFAHSILSSAQKNGLVKRRYAAVVHGR MAQMEGTVDAPIGRHPDSIIERTVTPDGQKAVTHFYVTCANDDMTSVALQLETGRTHQ IRVHMSYLGHPLCGDTLYGGTRQEIGRQALHSEHLSFIHPLTQENMRFHAPLPQDMSK LIKGENH*" /label="yjbO CDS" gene 1188094..1188945 /gene="yjbO" /locus_tag="BSU_11620" /old_locus_tag="BSU11620" /label="yjbO gene" downshifts 1188904 /Source="Nicolas_upshifts" /id="D632" /incds=0 /nref=203 /ntot=256 /MaxReadThrough="0.25796" /MaxDrop="5.73002" /score="21.4914497" /energy="-12.8" /TU="NA" /idTUdmin="U940" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1188958..1189692) /gene="prpE" /locus_tag="BSU_11630" /old_locus_tag="BSU11630" /EC_number="3.6.1.17" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12059787, 16740944, 21092197, 23824080, 28516732" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12059787, 16740944, 21092197, 23824080, 28516732; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphorylated protein phosphatase E and diadenosine-polyphosphate hydrolase" /protein_id="NP_389045.1" /db_xref="EnsemblGenomes-Gn:BSU11630" /db_xref="EnsemblGenomes-Tr:CAB13020" /db_xref="GOA:O31614" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR023937" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG13145" /db_xref="UniProtKB/Swiss-Prot:O31614" /translation="MAYDIISDIHGCYDEMTALIQKLGYTIKNGVPVHEEGRVLVFAG DLTDRGPKSIEVIRFVAGAYEKGAVRYVPGNHCNKLYRYLKGNPVKVMHGLETTAAEL EELSKDEKKSVSEQFMKLYETAPLYDILHNGELVVAHAGIRADDIGKYTRRVKDFVLY GDVTGETYPDGRPIRRDWAAAYNGKAWVVYGHTPVKEPRKVNRTINIDTGCVFGNQLT GFRFPEIETVSVPSSLPYDESRFRPI*" /label="prpE CDS" gene complement(1188958..1189692) /gene="prpE" /locus_tag="BSU_11630" /old_locus_tag="BSU11630" /label="prpE gene" downshifts complement(1188980) /Source="Nicolas_upshifts" /id="D633" /incds=0 /nref=22 /ntot=152 /MaxReadThrough="1.18091" /MaxDrop="3.57735" /score="3.24324561" /energy="-12.8" /TU="NA" /idTUdmin="U938" /TUdmin="-4312" /isTUend="FALSE" /label="downshifts" promotor_-35 1189814..1189818 /Source="Nicolas_upshift_promotors" /id="U941" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.768231768231768" /psig="0.996003996003996" /xcortree=1820 /SigmaFactorBS="ttctaaacaggattaagaccttatcACTTTatttttcatcat caccCTTGTTAAAATCGCGTTATGttttttaaaaatgaggttttgttctctgagtgag a" /listShort="S419, yjbQ, NA" /listLong="tenA, tenI, thiO, thiS, thiG, thiF, thiD, fabI" /label="promotor_-35" promotor_-10 1189835..1189854 /Source="Nicolas_upshift_promotors" /id="U941" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.768231768231768" /psig="0.996003996003996" /xcortree=1820 /SigmaFactorBS="ttctaaacaggattaagaccttatcACTTTatttttcatcat caccCTTGTTAAAATCGCGTTATGttttttaaaaatgaggttttgttctctgagtgag a" /listShort="S419, yjbQ, NA" /listLong="tenA, tenI, thiO, thiS, thiG, thiF, thiD, fabI" /label="promotor_-10" upshifts 1189849 /Source="Nicolas_upshifts" /id="U941" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.768231768231768" /psig="0.996003996003996" /xcortree=1820 /SigmaFactorBS="ttctaaacaggattaagaccttatcACTTTatttttcatcat caccCTTGTTAAAATCGCGTTATGttttttaaaaatgaggttttgttctctgagtgag a" /listShort="S419, yjbQ, NA" /listLong="tenA, tenI, thiO, thiS, thiG, thiF, thiD, fabI" /label="upshifts" S_feature 1189850..1189926 /Source="Nicolas_S_feature" /locus_tag="new_1240279_1240355" /HighExp="H2O2, Diami, dia15, Paraq, Oxctl, Heat, G180, Salt, BMM, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S419" CDS 1189927..1191771 /gene="kefQ" /locus_tag="BSU_11640" /old_locus_tag="BSU11640" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16850406, 21742892, 24330391; Product type t: transporter" /codon_start=1 /transl_table=11 /product="gated K+/H+ antiporter" /protein_id="NP_389046.1" /db_xref="EnsemblGenomes-Gn:BSU11640" /db_xref="EnsemblGenomes-Tr:CAB13021" /db_xref="GOA:O31615" /db_xref="InterPro:IPR003148" /db_xref="InterPro:IPR006037" /db_xref="InterPro:IPR006153" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR036721" /db_xref="SubtiList:BG13146" /db_xref="UniProtKB/Swiss-Prot:O31615" /translation="MAHTSVASLVVVLIVAFLTPILLHRFKLSIPVVVAEIIMGLIIG KSGLNLVVEGDTWLQTLSMLGFIFLMFLSGLEIDFSSFEKGKKKQFLPNGKEAPNTFA AASVIFVGIFILSLLLSYGFVLAGFIQNAFLMTLIISTISLGVVVPTLKEERIMNSNI GQIILLVAVIADLATMILLAVFSSLYGEDSGNMWLLMILFAAGVVLYFFGRVFKHRSF VQSMSKGTIQIGTRAIFTLIIVLVALSESLGAENILGAFLAGVLVSLLSPNKELVQQL DSFGYGFLIPIFFVMVGVKLDIWTLFQDKTILIMIPLLLLALLVSKIIPVMYLKKWYD NRTIFASGFLLTSTLSLVIAAATIGQQLHVISTNMSGALILVAVIASIFTPICFKKLY KREEQPEEKKTITFIGANQMTLPVTLELPEEEYDVRVVHVYQENAEEKLSESVFAVET ISDYEHETLESLGIFETDILVVATGNEDMNADIALLAKDKGTERVIASVGSPEHEAAL KEQGISIFSILLSTKTLLRALIEAPGVMKLLTNQESSLYQINMENSKYDGVILREFPL TGDVIFVRIFRGVDSIVPHGDTRLKLGDRLIVTGSRGYVTDLKKTLEG*" /label="kefQ CDS" gene 1189927..1191771 /gene="kefQ" /locus_tag="BSU_11640" /old_locus_tag="BSU11640" /label="kefQ gene" misc_feature complement(1190254..1190273) /Source="Nicolas_upshift_promotors" /id="U942" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig="0.996003996003996" /xcortree=3108 /SigmaFactorBS="taatcagggtcatcaaaaatgcattttggataaatccggcca agacgaacccataggacaagagcAATGATAAAATAAAAATACCgacgaaaataacaga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1190278) /Source="Nicolas_upshifts" /id="U942" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig="0.996003996003996" /xcortree=3108 /SigmaFactorBS="taatcagggtcatcaaaaatgcattttggataaatccggcca agacgaacccataggacaagagcAATGATAAAATAAAAATACCgacgaaaataacaga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1191773..1191780 /Source="Nicolas_upshift_promotors" /id="U943" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.878121878121878" /psig="0.999000999001" /xcortree=2884 /SigmaFactorBS="taacggatcttaagaaaacattggaaggataaaTCTTGACCa aataaggattcgTGTTAATATAGAGGTGCAGAacaattcaatatgtattcgtttaacc a" /listShort="NA, tenA, tenI, thiO, thiS, thiG, thiF, thiD" /listLong="fabI" /label="promotor_-35" promotor_-10 1191794..1191813 /Source="Nicolas_upshift_promotors" /id="U943" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.878121878121878" /psig="0.999000999001" /xcortree=2884 /SigmaFactorBS="taacggatcttaagaaaacattggaaggataaaTCTTGACCa aataaggattcgTGTTAATATAGAGGTGCAGAacaattcaatatgtattcgtttaacc a" /listShort="NA, tenA, tenI, thiO, thiS, thiG, thiF, thiD" /listLong="fabI" /label="promotor_-10" upshifts 1191800 /Source="Nicolas_upshifts" /id="U943" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.878121878121878" /psig="0.999000999001" /xcortree=2884 /SigmaFactorBS="taacggatcttaagaaaacattggaaggataaaTCTTGACCa aataaggattcgTGTTAATATAGAGGTGCAGAacaattcaatatgtattcgtttaacc a" /listShort="NA, tenA, tenI, thiO, thiS, thiG, thiF, thiD" /listLong="fabI" /label="upshifts" misc_RNA 1191833..1191941 /gene="tswA" /locus_tag="BSU_misc_RNA_14" /product="thiamine pyrophosphate riboswitch" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11470904, 12410317, 15862294, 16728979, 16962976, 17307816, 18179415, 18776013; Product type n: RNA" /function="16.3: Control" /label="tswA RNA" gene 1191833..1191941 /gene="tswA" /locus_tag="BSU_misc_RNA_14" /label="tswA gene" downshifts 1191936 /Source="Nicolas_upshifts" /id="D634" /incds=0 /nref=20 /ntot=84 /MaxReadThrough="7.67021" /MaxDrop="5.27759" /score="34.8346124" /energy="-12.5" /TU="U943" /idTUdmin="U941" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS 1192020..1192730 /gene="tenA" /locus_tag="BSU_11650" /old_locus_tag="BSU11650" /EC_number="3.5.99.2" /function="4.11: Thiamine" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15709744, 15858269, 16356850, 17618314, 18054064, 24311574" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15709744, 15858269, 16356850, 17618314, 18054064, 24311574; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="thiaminase II" /protein_id="NP_389047.1" /db_xref="EnsemblGenomes-Gn:BSU11650" /db_xref="EnsemblGenomes-Tr:CAB13022" /db_xref="GOA:P25052" /db_xref="InterPro:IPR004305" /db_xref="InterPro:IPR016084" /db_xref="InterPro:IPR027574" /db_xref="PDB:1TO9" /db_xref="PDB:1TYH" /db_xref="PDB:1YAF" /db_xref="PDB:1YAK" /db_xref="PDB:2QCX" /db_xref="SubtiList:BG10791" /db_xref="UniProtKB/Swiss-Prot:P25052" /translation="MKFSEECRSAAAEWWEGSFVHPFVQGIGDGTLPIDRFKYYVLQD SYYLTHFAKVQSFGAAYAKDLYTTGRMASHAQGTYEAEMALHREFAELLEISEEERKA FKPSPTAYSYTSHMYRSVLSGNFAEILAALLPCYWLYYEVGEKLLHCDPGHPIYQKWI GTYGGDWFRQQVEEQINRFDELAENSTEEVRAKMKENFVISSYYEYQFWGMAYRKEGW SDSAIKEVEECGASRHNG*" /label="tenA CDS" gene 1192020..1192730 /gene="tenA" /locus_tag="BSU_11650" /old_locus_tag="BSU11650" /label="tenA gene" CDS 1192705..1193322 /gene="tenI" /locus_tag="BSU_11660" /old_locus_tag="BSU11660" /EC_number="5.3.99.10" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15709744, 15858269, 16356850, 21534620" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15709744, 15858269, 16356850, 21534620; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thiazole tautomerase" /protein_id="NP_389048.1" /db_xref="EnsemblGenomes-Gn:BSU11660" /db_xref="EnsemblGenomes-Tr:CAB13023" /db_xref="GOA:P25053" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR022998" /db_xref="InterPro:IPR036206" /db_xref="PDB:1YAD" /db_xref="PDB:3QH2" /db_xref="SubtiList:BG10792" /db_xref="UniProtKB/Swiss-Prot:P25053" /translation="MELHAITDDSKPVEELARIIITIQNEVDFIHIRERSKSAADILK LLDLIFEGGIDKRKLVMNGRVDIALFSTIHRVQLPSGSFSPKQIRARFPHLHIGRSVH SLEEAVQAEKEDADYVLFGHVFETDCKKGLEGRGVSLLSDIKQRISIPVIAIGGMTPD RLRDVKQAGADGIAVMSGIFSSAEPLEAARRYSRKLKEMRYEKAL*" /label="tenI CDS" gene 1192705..1193322 /gene="tenI" /locus_tag="BSU_11660" /old_locus_tag="BSU11660" /label="tenI gene" CDS 1193306..1194415 /gene="thiO" /locus_tag="BSU_11670" /old_locus_tag="BSU11670" /EC_number="1.4.3.19" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9827558, 11744710, 12627963, 15105420, 19751796, 26443755" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9827558, 11744710, 12627963, 15105420, 19751796, 26443755; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="FAD-dependent glycine oxidase" /protein_id="NP_389049.1" /db_xref="EnsemblGenomes-Gn:BSU11670" /db_xref="EnsemblGenomes-Tr:CAB13024" /db_xref="GOA:O31616" /db_xref="InterPro:IPR006076" /db_xref="InterPro:IPR012727" /db_xref="InterPro:IPR036188" /db_xref="PDB:1NG3" /db_xref="PDB:1NG4" /db_xref="PDB:1RYI" /db_xref="PDB:3IF9" /db_xref="SubtiList:BG13147" /db_xref="UniProtKB/Swiss-Prot:O31616" /translation="MKRHYEAVVIGGGIIGSAIAYYLAKENKNTALFESGTMGGRTTS AAAGMLGAHAECEERDAFFDFAMHSQRLYKGLGEELYALSGVDIRQHNGGMFKLAFSE EDVLQLRQMDDLDSVSWYSKEEVLEKEPYASGDIFGASFIQDDVHVEPYFVCKAYVKA AKMLGAEIFEHTPVLHVERDGEALFIKTPSGDVWANHVVVASGVWSGMFFKQLGLNNA FLPVKGECLSVWNDDIPLTKTLYHDHCYIVPRKSGRLVVGATMKPGDWSETPDLGGLE SVMKKAKTMLPAIQNMKVDRFWAGLRPGTKDGKPYIGRHPEDSRILFAAGHFRNGILL APATGALISDLIMNKEVNQDWLHAFRIDRKEAVQI*" /label="thiO CDS" gene 1193306..1194415 /gene="thiO" /locus_tag="BSU_11670" /old_locus_tag="BSU11670" /label="thiO gene" CDS 1194415..1194615 /gene="thiS" /locus_tag="BSU_11680" /old_locus_tag="BSU11680" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10939241, 14567704, 14757766, 15489164, 22616866, 26443755; Product type c : carrier" /codon_start=1 /transl_table=11 /product="sulfur carrier for synthesis of hydroxyethylthiazole phosphate" /protein_id="NP_389050.1" /db_xref="EnsemblGenomes-Gn:BSU11680" /db_xref="EnsemblGenomes-Tr:CAB13025" /db_xref="GOA:O31617" /db_xref="InterPro:IPR003749" /db_xref="InterPro:IPR010035" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR016155" /db_xref="PDB:1TYG" /db_xref="SubtiList:BG13148" /db_xref="UniProtKB/Swiss-Prot:O31617" /translation="MLQLNGKDVKWKKDTGTIQDLLASYQLENKIVIVERNKEIIGKE RYHEVELCDRDVIEIVHFVGGG*" /label="thiS CDS" gene 1194415..1194615 /gene="thiS" /locus_tag="BSU_11680" /old_locus_tag="BSU11680" /label="thiS gene" CDS 1194612..1195382 /gene="thiG" /locus_tag="BSU_11690" /old_locus_tag="BSU11690" /EC_number="2.8.1.10" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 12627963, 14567704, 14757766, 15489164, 22938038" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 12627963, 14567704, 14757766, 15489164, 22938038; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="hydroxyethylthiazole phosphate synthetase (thiamine biosynthesis)" /protein_id="NP_389051.1" /db_xref="EnsemblGenomes-Gn:BSU11690" /db_xref="EnsemblGenomes-Tr:CAB13026" /db_xref="GOA:O31618" /db_xref="InterPro:IPR008867" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR033983" /db_xref="PDB:1TYG" /db_xref="PDB:1XM3" /db_xref="SubtiList:BG13149" /db_xref="UniProtKB/Swiss-Prot:O31618" /translation="MSMLTIGGKSFQSRLLLGTGKYPSFDIQKEAVAVSESDILTFAV RRMNIFEASQPNFLEQLDLSKYTLLPNTAGASTAEEAVRIARLAKASGLCDMIKVEVI GCSRSLLPDPVETLKASEQLLEEGFIVLPYTSDDVVLARKLEELGVHAIMPGASPIGS GQGILNPLNLSFIIEQAKVPVIVDAGIGSPKDAAYAMELGADGVLLNTAVSGADDPVK MARAMKLAVEAGRLSYEAGRIPLKQYGTASSPGEGLPV*" /label="thiG CDS" gene 1194612..1195382 /gene="thiG" /locus_tag="BSU_11690" /old_locus_tag="BSU11690" /label="thiG gene" CDS 1195379..1196389 /gene="thiF" /locus_tag="BSU_11700" /old_locus_tag="BSU11700" /EC_number="2.7.7.73" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 14567704, 14757766, 15489164, 16388576, 26443755" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 14567704, 14757766, 15489164, 16388576, 26443755; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="adenylate transferase and sulfur transferase (thiamine biosynthesis)" /protein_id="NP_389052.1" /db_xref="EnsemblGenomes-Gn:BSU11700" /db_xref="EnsemblGenomes-Tr:CAB13027" /db_xref="GOA:O31619" /db_xref="InterPro:IPR000594" /db_xref="InterPro:IPR035985" /db_xref="SubtiList:BG13150" /db_xref="UniProtKB/Swiss-Prot:O31619" /translation="MTGRYSRQELFAPIGPSGQKKLKEARAVIIGAGALGTASAEMLV RAGVGSVKIADRDYVEWSNLQRQQLYTEDDVKKEMPKAAAAERRLRSINSDVDVTGLV MDVTAENIFELIRDASIIVDAADNFETRLIVNDAAVKEGIPFLYGACVGSYGLTFTVV PGSTPCLHCLLDALPIGGATCDTAGIISPAVLQVAVFQVTDALKLLTGEECEPVLRSF DLWKNERSEVRAASLKHDACPSCGTKDFPFLSYENQTKAAVLCGRNTVQIRSSITKEA DLEALAGQLRQAGLEVAANPYLISCRSDDMKMVLFRDGRALIHGTNDIARAKSIYHKW IG*" /label="thiF CDS" gene 1195379..1196389 /gene="thiF" /locus_tag="BSU_11700" /old_locus_tag="BSU11700" /label="thiF gene" CDS 1196408..1197223 /gene="thiD" /locus_tag="BSU_11710" /old_locus_tag="BSU11710" /EC_number="2.7.4.7" /EC_number="2.7.1.49" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 12627963, 14973012, 16952958, 17012797, 26443755" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 12627963, 14973012, 16952958, 17012797, 26443755; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="phosphomethylpyrimidine kinase, 4-amino-5-hydroxymethyl-2-methylpyrimidine and 4-amino-5-hydroxymethyl-2-methylpyrimidine pyrophosphate kinase" /protein_id="NP_389053.1" /db_xref="EnsemblGenomes-Gn:BSU11710" /db_xref="EnsemblGenomes-Tr:CAB13028" /db_xref="GOA:O31620" /db_xref="InterPro:IPR004399" /db_xref="InterPro:IPR013749" /db_xref="InterPro:IPR029056" /db_xref="SubtiList:BG13151" /db_xref="UniProtKB/Swiss-Prot:O31620" /translation="MSIYKALTIAGSDSGGGAGIQADIKTFQELDVFGMSAITAVTAQ NTLGVHGVHPLTVETLRQQIDAVAEDLRPDAVKTGMLWNADMIEEVARKIDEYGFNRV IVDPVMIAKGGASLLRDESVATLKELLIPRSYAITPNVPEAETLTGMTISSLDDRKKA AEQLVKMGAQHVIIKGGHQPEDNHITDLLFDGSMFMQITHPYINTKHTHGTGCTFAAA LTAQTAKGDSIHQAFEVAANFVREAVENTLGIGSGHGPTNHFAFKRNSLNTSR*" /label="thiD CDS" gene 1196408..1197223 /gene="thiD" /locus_tag="BSU_11710" /old_locus_tag="BSU11710" /label="thiD gene" downshifts 1197197 /Source="Nicolas_upshifts" /id="D635" /incds=0 /nref=128 /ntot=172 /MaxReadThrough="3.33485" /MaxDrop="5.0154" /score="3.40314581" /energy="-14.8" /TU="U943" /idTUdmin="U943" /TUdmin="-89" /isTUend="FALSE" /label="downshifts" promotor_-35 1197270..1197276 /Source="Nicolas_upshift_promotors" /id="U944" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.619380619380619" /psig=1 /xcortree=2189 /SigmaFactorBS="gtgatctcttttgcgtttgctacggtatgcgCTTTTCAtctg gacaaggtTATGATATGATAGGAATTAAgatcaggtactaatactatgtctttattaa a" /listShort="fabI, cotO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1197289..1197308 /Source="Nicolas_upshift_promotors" /id="U944" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.619380619380619" /psig=1 /xcortree=2189 /SigmaFactorBS="gtgatctcttttgcgtttgctacggtatgcgCTTTTCAtctg gacaaggtTATGATATGATAGGAATTAAgatcaggtactaatactatgtctttattaa a" /listShort="fabI, cotO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1197299 /Source="Nicolas_upshifts" /id="U944" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.619380619380619" /psig=1 /xcortree=2189 /SigmaFactorBS="gtgatctcttttgcgtttgctacggtatgcgCTTTTCAtctg gacaaggtTATGATATGATAGGAATTAAgatcaggtactaatactatgtctttattaa a" /listShort="fabI, cotO" /GFF_Attribute="listLong" /label="upshifts" CDS 1197359..1198135 /gene="fabI" /locus_tag="BSU_11720" /old_locus_tag="BSU11720" /EC_number="1.3.1.9" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11007778, 15105103, 21185310, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11007778, 15105103, 21185310, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enoyl-acyl carrier protein reductase" /protein_id="NP_389054.2" /db_xref="EnsemblGenomes-Gn:BSU11720" /db_xref="EnsemblGenomes-Tr:CAB13029" /db_xref="GOA:P54616" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR014358" /db_xref="InterPro:IPR036291" /db_xref="PDB:3OIF" /db_xref="PDB:3OIG" /db_xref="SubtiList:BG13152" /db_xref="UniProtKB/Swiss-Prot:P54616" /translation="MNFSLEGRNIVVMGVANKRSIAWGIARSLHEAGARLIFTYAGER LEKSVHELAGTLDRNDSIILPCDVTNDAEIETCFASIKEQVGVIHGIAHCIAFANKEE LVGEYLNTNRDGFLLAHNISSYSLTAVVKAARPMMTEGGSIVTLTYLGGELVMPNYNV MGVAKASLDASVKYLAADLGKENIRVNSISAGPIRTLSAKGISDFNSILKDIEERAPL RRTTTPEEVGDTAAFLFSDMSRGITGENLHVDSGFHITAR*" /label="fabI CDS" gene 1197359..1198135 /gene="fabI" /locus_tag="BSU_11720" /old_locus_tag="BSU11720" /label="fabI gene" downshifts 1198124 /Source="Nicolas_upshifts" /id="D636" /incds=0 /nref=229 /ntot=313 /MaxReadThrough="3.12901" /MaxDrop="6.64182" /score="33.5478109" /energy="-11.8" /TU="U944" /idTUdmin="U944" /TUdmin="-416" /isTUend="FALSE" /label="downshifts" promotor_-35 1198183..1198188 /Source="Nicolas_upshift_promotors" /id="U945" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.968031968031968" /psig="0.968031968031968" /xcortree=1095 /SigmaFactorBS="tcaagcaatcccgaatagggattgcttttttatttCTTCTGa ttttcagctttctgTCATATAGATAGAATATGAcacaatcggagggatgaagatgtct a" /listShort="cotO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1198204..1198222 /Source="Nicolas_upshift_promotors" /id="U945" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.968031968031968" /psig="0.968031968031968" /xcortree=1095 /SigmaFactorBS="tcaagcaatcccgaatagggattgcttttttatttCTTCTGa ttttcagctttctgTCATATAGATAGAATATGAcacaatcggagggatgaagatgtct a" /listShort="cotO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1198208 /Source="Nicolas_upshifts" /id="U945" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.968031968031968" /psig="0.968031968031968" /xcortree=1095 /SigmaFactorBS="tcaagcaatcccgaatagggattgcttttttatttCTTCTGa ttttcagctttctgTCATATAGATAGAATATGAcacaatcggagggatgaagatgtct a" /listShort="cotO" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1198220..1198234) /Source="Nicolas_upshift_promotors" /id="U946" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.997002997002997" /psig="0.001998001998002" /xcortree=1241 /SigmaFactorBS="gagcggttttttatccgcgtttcttttcttattaGACATctt catcCCTCCGATTGTGTCAtattctatctatatgacagaaagctgaaaatcagaagaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1198220) /Source="Nicolas_upshifts" /id="U946" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.997002997002997" /psig="0.001998001998002" /xcortree=1241 /SigmaFactorBS="gagcggttttttatccgcgtttcttttcttattaGACATctt catcCCTCCGATTGTGTCAtattctatctatatgacagaaagctgaaaatcagaagaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1198236..1198919 /gene="cotO" /locus_tag="BSU_11730" /old_locus_tag="BSU11730" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16321932" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16321932; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore outer coat protein" /protein_id="NP_389055.1" /db_xref="EnsemblGenomes-Gn:BSU11730" /db_xref="EnsemblGenomes-Tr:CAB13030" /db_xref="GOA:O31622" /db_xref="InterPro:IPR025439" /db_xref="SubtiList:BG13153" /db_xref="UniProtKB/Swiss-Prot:O31622" /translation="MKMSNKKRNADKKPLMYIVQPDYAETTRSSMQEIVIKRKADKPA PPKAEEKPAYHEKQQEEAVAQDVLQEDQKPAAEPVSQQTQEAREPENIKSQEEQKAEP QAVEETVEHEPPKAEKKEEPALEARKPEKEPEAVHSADKAEEKAPPARKVKKPMSKMT IHEKIDFLTKLPHNMPRALCLIEANGRTYRGVIVGRRNDSVLLRTTGNGAPTELAIDD ITSLHPLGF*" /label="cotO CDS" gene 1198236..1198919 /gene="cotO" /locus_tag="BSU_11730" /old_locus_tag="BSU11730" /label="cotO gene" promotor_-35 complement(1198242..1198246) /Source="Nicolas_upshift_promotors" /id="U946" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.997002997002997" /psig="0.001998001998002" /xcortree=1241 /SigmaFactorBS="gagcggttttttatccgcgtttcttttcttattaGACATctt catcCCTCCGATTGTGTCAtattctatctatatgacagaaagctgaaaatcagaagaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1198914 /Source="Nicolas_upshifts" /id="D637" /incds=0 /nref=4 /ntot=40 /MaxReadThrough="3.37645" /MaxDrop="4.6587" /score="18.0229289" /energy="-13.4" /TU="U945" /idTUdmin="U945" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" downshifts 1199002 /Source="Nicolas_upshifts" /id="D638" /incds=0 /nref=1 /ntot=29 /MaxReadThrough="2.44926" /MaxDrop="4.55934" /score="18.0229289" /energy="-13.4" /TU="NA" /idTUdmin="U945" /TUdmin=22 /isTUend="TRUE" /label="downshifts" CDS complement(1199013..1199459) /gene="cotZ" /locus_tag="BSU_11740" /old_locus_tag="BSU11740" /function="16.13: Shape" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:7519271, 8509331, 19933362, 26341943, 27320701" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7519271, 8509331, 19933362, 26341943, 27320701; Product type s: structure" /codon_start=1 /transl_table=11 /product="spore coat protein (insoluble fraction, crust layer)" /protein_id="NP_389056.1" /db_xref="EnsemblGenomes-Gn:BSU11740" /db_xref="EnsemblGenomes-Tr:CAB13031" /db_xref="GOA:Q08312" /db_xref="InterPro:IPR019593" /db_xref="SubtiList:BG10499" /db_xref="UniProtKB/Swiss-Prot:Q08312" /translation="MSQKTSSCVREAVENIEDLQNAVEEDCPTGCHSKLLSVSHSLGD TVPFAIFTSKSTPLVAFGNVGELDNGPCFNTVFFRVERVHGSCATLSLLIAFDEHKHI LDFTDKDTVCEVFRLEKTNYCIEVDLDCFCAINCLNPRLINRTHHH*" /label="cotZ CDS" gene complement(1199013..1199459) /gene="cotZ" /locus_tag="BSU_11740" /old_locus_tag="BSU11740" /label="cotZ gene" downshifts complement(1199034) /Source="Nicolas_upshifts" /id="D639" /incds=0 /nref=7 /ntot=50 /MaxReadThrough="8.44444" /MaxDrop="7.17581" /score="2.03943557" /energy="-9.3" /TU="U949" /idTUdmin="U950" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1199460..1199586) /Source="Nicolas_S_feature" /locus_tag="new_1249889_1250015_c" /HighExp="S8, S7, S6, BT, S5, B36, G/S, Pyr, B60, SMMPr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigEF" /TUshortPSig="1, 0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S420" CDS complement(1199587..1200075) /gene="cotY" /locus_tag="BSU_11750" /old_locus_tag="BSU11750" /function="16.13: Shape" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:7519271, 8509331, 14766913, 26341943, 26821119" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7519271, 8509331, 14766913, 26341943, 26821119; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="outer spore coat protein (crust layer, insolublefraction)" /protein_id="NP_389057.1" /db_xref="EnsemblGenomes-Gn:BSU11750" /db_xref="EnsemblGenomes-Tr:CAB13032" /db_xref="GOA:Q08311" /db_xref="InterPro:IPR019593" /db_xref="SubtiList:BG10498" /db_xref="UniProtKB/Swiss-Prot:Q08311" /translation="MSCGKTHGRHENCVCDAVEKILAEQEAVEEQCPTGCYTNLLNPT IAGKDTIPFLVFDKKGGLFSTFGNVGGFVDDMQCFESIFFRVEKLCDCCATLSILRPV DVKGDTLSVCHPCDPDFFGLEKTDFCIEVDLGCFCAIQCLSPELVDRTSPHKDKKHHH NG*" /label="cotY CDS" gene complement(1199587..1200075) /gene="cotY" /locus_tag="BSU_11750" /old_locus_tag="BSU11750" /label="cotY gene" promotor_-35 1199755..1199761 /Source="Nicolas_upshift_promotors" /id="U947" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.53046953046953" /psig="0.653346653346653" /xcortree=1630 /SigmaFactorBS="agggtggcaaacacttaaggtATCGCCTttgacatcgaccgg GCGTAAAATAGACAGTGTTGcacagcaatcgcataatttttcgacgcggaagaaaatg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1199776..1199795 /Source="Nicolas_upshift_promotors" /id="U947" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.53046953046953" /psig="0.653346653346653" /xcortree=1630 /SigmaFactorBS="agggtggcaaacacttaaggtATCGCCTttgacatcgaccgg GCGTAAAATAGACAGTGTTGcacagcaatcgcataatttttcgacgcggaagaaaatg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1199794 /Source="Nicolas_upshifts" /id="U947" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.53046953046953" /psig="0.653346653346653" /xcortree=1630 /SigmaFactorBS="agggtggcaaacacttaaggtATCGCCTttgacatcgaccgg GCGTAAAATAGACAGTGTTGcacagcaatcgcataatttttcgacgcggaagaaaatg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1200071..1200075 /Source="Nicolas_upshift_promotors" /id="U948" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.997002997002997" /psig="0.002997002997003" /xcortree=1244 /SigmaFactorBS="tctcatgccggccatgggtttttccgcagCTCATtgatttca GCTCCTTCTTTATAGggtatttgactttagtccttaacaacatatgtacccgtgcccc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1200084..1200098 /Source="Nicolas_upshift_promotors" /id="U948" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.997002997002997" /psig="0.002997002997003" /xcortree=1244 /SigmaFactorBS="tctcatgccggccatgggtttttccgcagCTCATtgatttca GCTCCTTCTTTATAGggtatttgactttagtccttaacaacatatgtacccgtgcccc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1200102 /Source="Nicolas_upshifts" /id="U948" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.997002997002997" /psig="0.002997002997003" /xcortree=1244 /SigmaFactorBS="tctcatgccggccatgggtttttccgcagCTCATtgatttca GCTCCTTCTTTATAGggtatttgactttagtccttaacaacatatgtacccgtgcccc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1200112..1200131) /Source="Nicolas_upshift_promotors" /id="U949" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1280 /SigmaFactorBS="tattttccaagcatatgatgaatatatagacgttcACCCACA CCAagtggggcacgggTACATATGTTGTTAAGGACTaaagtcaaataccctataaaga a" /listShort="cotY, S420, cotZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1200129) /Source="Nicolas_upshifts" /id="U949" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1280 /SigmaFactorBS="tattttccaagcatatgatgaatatatagacgttcACCCACA CCAagtggggcacgggTACATATGTTGTTAAGGACTaaagtcaaataccctataaaga a" /listShort="cotY, S420, cotZ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1200145..1200154) /Source="Nicolas_upshift_promotors" /id="U949" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1280 /SigmaFactorBS="tattttccaagcatatgatgaatatatagacgttcACCCACA CCAagtggggcacgggTACATATGTTGTTAAGGACTaaagtcaaataccctataaaga a" /listShort="cotY, S420, cotZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1200161..1200179) /Source="Nicolas_upshift_promotors" /id="U950" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1006 /SigmaFactorBS="cttgtcctctaggacctaaaagcagagctaaaaacgctCTGC TTtttcttattttccaaGCATATGATGAATATATAGacgttcacccacaccaagtggg g" /listShort="cotY, S420, cotZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1200178) /Source="Nicolas_upshifts" /id="U950" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1006 /SigmaFactorBS="cttgtcctctaggacctaaaagcagagctaaaaacgctCTGC TTtttcttattttccaaGCATATGATGAATATATAGacgttcacccacaccaagtggg g" /listShort="cotY, S420, cotZ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1200195..1200200) /Source="Nicolas_upshift_promotors" /id="U950" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1006 /SigmaFactorBS="cttgtcctctaggacctaaaagcagagctaaaaacgctCTGC TTtttcttattttccaaGCATATGATGAATATATAGacgttcacccacaccaagtggg g" /listShort="cotY, S420, cotZ" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1200212 /Source="Nicolas_upshifts" /id="D640" /incds=0 /nref=1 /ntot=14 /MaxReadThrough="1.28604" /MaxDrop="4.18677" /score="-9.76125107" /energy="-10.4" /TU="NA" /idTUdmin="U948" /TUdmin=22 /isTUend="TRUE" /label="downshifts" CDS complement(1200227..1200745) /gene="cotX" /locus_tag="BSU_11760" /old_locus_tag="BSU11760" /function="16.13: Shape" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:7519271, 8509331, 10400595, 10788508, 12031481, 19304857, 26821119" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7519271, 8509331, 10400595, 10788508, 12031481, 19304857, 26821119; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein (insoluble fraction)" /protein_id="NP_389058.1" /db_xref="EnsemblGenomes-Gn:BSU11760" /db_xref="EnsemblGenomes-Tr:CAB13033" /db_xref="GOA:Q08313" /db_xref="InterPro:IPR011428" /db_xref="SubtiList:BG10500" /db_xref="UniProtKB/Swiss-Prot:Q08313" /translation="MESRPYSWVALDPDCDHPLDDKEKDKEKHERKCHCDVCCNGNGF FGNDNAFIDQDLAQANLNKQVSDETIIIRDSCDINVTSTDVQAVTSVVTALNAAVVTA TLTSIADGVIAELVAQDLLQLTANKQVNRQKLLIECSRGVNVTTVDADIATLISTATN TLVAILVITLVL*" /label="cotX CDS" gene complement(1200227..1200745) /gene="cotX" /locus_tag="BSU_11760" /old_locus_tag="BSU11760" /label="cotX gene" downshifts complement(1200251) /Source="Nicolas_upshifts" /id="D641" /incds=0 /nref=76 /ntot=102 /MaxReadThrough="1.79219" /MaxDrop="8.69761" /score="18.5755652" /energy="-10.4" /TU="U952" /idTUdmin="U952" /TUdmin="-29" /isTUend="FALSE" /label="downshifts" downshifts 1200256 /Source="Nicolas_upshifts" /id="D642" /incds=0 /nref=1 /ntot=8 /MaxReadThrough="1.2156" /MaxDrop="3.69222" /score="-9.76125107" /energy="-10.4" /TU="NA" /idTUdmin="U948" /TUdmin=66 /isTUend="FALSE" /label="downshifts" S_feature complement(1200746..1200843) /Source="Nicolas_S_feature" /locus_tag="new_1251175_1251272_c" /HighExp="S8, S7, S6, BT, B36, G/S, Pyr, S5, B60, SMMPr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.748" /TUlongSig="SigK" /TUlongPSig="0.98" /label="S421" CDS complement(1200844..1201161) /gene="cotW" /locus_tag="BSU_11770" /old_locus_tag="BSU11770" /function="16.5: Explore" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8509331, 19304857, 21665972, 25872412" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8509331, 19304857, 21665972, 25872412; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein (outemost layer)" /protein_id="NP_389059.1" /db_xref="EnsemblGenomes-Gn:BSU11770" /db_xref="EnsemblGenomes-Tr:CAB13034" /db_xref="GOA:Q08310" /db_xref="SubtiList:BG10497" /db_xref="UniProtKB/Swiss-Prot:Q08310" /translation="MSDNDKFKEELAKLPEVDPMTKMLVQNIFSKHGVTKDKMKKVSD EEKEMLLNLVKDLQAKSQALIENQKKKKEEAAAQEQKNTKPLSRREQLIEQIRQRRKN DNN*" /label="cotW CDS" gene complement(1200844..1201161) /gene="cotW" /locus_tag="BSU_11770" /old_locus_tag="BSU11770" /label="cotW gene" CDS complement(1201202..1201588) /gene="cotV" /locus_tag="BSU_11780" /old_locus_tag="BSU11780" /function="16.13: Shape" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:7519271, 8509331" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7519271, 8509331; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein (insoluble fraction)" /protein_id="NP_389060.1" /db_xref="EnsemblGenomes-Gn:BSU11780" /db_xref="EnsemblGenomes-Tr:CAB13035" /db_xref="GOA:Q08309" /db_xref="InterPro:IPR011428" /db_xref="SubtiList:BG10496" /db_xref="UniProtKB/Swiss-Prot:Q08309" /translation="MSFEEKVESLHPAIFEQLSSEFEQQIEVIDCENITIDTSHITAA LSIQAFVTTMIIVATQLVIADEDLADAVASEILILDSSQIKKRTIIKIINSRNIKITL SADEIITFVQILLQVLNSILSELDVL*" /label="cotV CDS" gene complement(1201202..1201588) /gene="cotV" /locus_tag="BSU_11780" /old_locus_tag="BSU11780" /label="cotV gene" promotor_-35 1201584..1201588 /Source="Nicolas_upshift_promotors" /id="U951" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.99100899100899" /psig="0.005994005994006" /xcortree=1245 /SigmaFactorBS="ttgctcaaatattgcagggtgcagggattcgactttttcttc aaatGACATaaccttcACTCCTTTCTTATCCatactctatataatgcaaatggggtgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1201596..1201610 /Source="Nicolas_upshift_promotors" /id="U951" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.99100899100899" /psig="0.005994005994006" /xcortree=1245 /SigmaFactorBS="ttgctcaaatattgcagggtgcagggattcgactttttcttc aaatGACATaaccttcACTCCTTTCTTATCCatactctatataatgcaaatggggtgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1201598 /Source="Nicolas_upshifts" /id="U951" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.99100899100899" /psig="0.005994005994006" /xcortree=1245 /SigmaFactorBS="ttgctcaaatattgcagggtgcagggattcgactttttcttc aaatGACATaaccttcACTCCTTTCTTATCCatactctatataatgcaaatggggtgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1201608..1201627) /Source="Nicolas_upshift_promotors" /id="U952" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.748251748251748" /psig="0.748251748251748" /xcortree=1351 /SigmaFactorBS="catgaattgtatcttgtccggcagaaaattggttatttttat taTtCcGctctgcaccccattTGCATTATATAGAGTATGGAtaagaaaggagtgaagg t" /listShort="cotV, cotW, S421, cotX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1201630) /Source="Nicolas_upshifts" /id="U952" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.748251748251748" /psig="0.748251748251748" /xcortree=1351 /SigmaFactorBS="catgaattgtatcttgtccggcagaaaattggttatttttat taTtCcGctctgcaccccattTGCATTATATAGAGTATGGAtaagaaaggagtgaagg t" /listShort="cotV, cotW, S421, cotX" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1201632..1202136) /Source="Nicolas_S_feature" /locus_tag="new_1252061_1252565_c" /HighExp="S8, S6, S7, BT, S5, B36, Pyr, C30, G/S, nit" /AntisenseName="yjcA" /AntisenseCor="0.69838474492609404" /AntisenseRegPval="-39.9" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.98" /TUlongSig="NA" /TUlongPSig="NA" /label="S422" promotor_-35 1201685..1201690 /Source="Nicolas_upshift_promotors" /id="U953" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1132 /SigmaFactorBS="aataaaaataaccaattttctgccggacaagatacaaTTCAT GaagaatagggttttgGCATATATGTGAAGGGATCatgattggcaaaggagtgaacga g" /listShort="yjcA, S423" /listLong="yjzK, yjcZ, S424, spoVIF, S425" /label="promotor_-35" promotor_-10 1201706..1201724 /Source="Nicolas_upshift_promotors" /id="U953" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1132 /SigmaFactorBS="aataaaaataaccaattttctgccggacaagatacaaTTCAT GaagaatagggttttgGCATATATGTGAAGGGATCatgattggcaaaggagtgaacga g" /listShort="yjcA, S423" /listLong="yjzK, yjcZ, S424, spoVIF, S425" /label="promotor_-10" upshifts 1201708 /Source="Nicolas_upshifts" /id="U953" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1132 /SigmaFactorBS="aataaaaataaccaattttctgccggacaagatacaaTTCAT GaagaatagggttttgGCATATATGTGAAGGGATCatgattggcaaaggagtgaacga g" /listShort="yjcA, S423" /listLong="yjzK, yjcZ, S424, spoVIF, S425" /label="upshifts" CDS 1201748..1202104 /gene="yjcA" /locus_tag="BSU_11790" /old_locus_tag="BSU11790" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:14523132, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14523132, 15849754, 16850406; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sporulation-specific protein" /protein_id="NP_389061.1" /db_xref="EnsemblGenomes-Gn:BSU11790" /db_xref="EnsemblGenomes-Tr:CAB13036" /db_xref="GOA:O31623" /db_xref="InterPro:IPR010773" /db_xref="SubtiList:BG13154" /db_xref="UniProtKB/Swiss-Prot:O31623" /translation="MVINGLTIVLLSLAVFRLARLLVFDTIMAPLRSLFHEEKEEKDA DGNIETYIVIKGTGVRAFIGELLSCYWCTGVWCAGFLILCQAVIPQAAQWLILLLAIA GLAGIIETLVSKWLQE*" /label="yjcA CDS" gene 1201748..1202104 /gene="yjcA" /locus_tag="BSU_11790" /old_locus_tag="BSU11790" /label="yjcA gene" promotor_-35 1202114..1202123 /Source="Nicolas_upshift_promotors" /id="U955" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1353 /SigmaFactorBS="gctcgtatcaaaatggctgcaagaataaggcgttaccACCAG CAACTttctgtcagaataCGCATAAAGTAGCATATAtgacataaggaaaggaagggga c" /listShort="S423, yjzK" /listLong="yjcZ, S424, spoVIF, S425" /label="promotor_-35" promotor_-10 complement(1202121..1202140) /Source="Nicolas_upshift_promotors" /id="U954" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=1256 /SigmaFactorBS="atgatgctgattcatttttgtccccttcctttcCTTATGTCA TatatgctactttaTGCGTATTCTGACAGAAAGTtgctggtggtaacgccttattctt g" /listShort="S422" /listLong="cotV, cotW, S421, cotX" /label="promotor_-10" CDS complement(1202129..1202362) /locus_tag="BSU_11798" /old_locus_tag="BSU11798" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="protein remnant" /db_xref="PSEUDO:SOX90549.1" /translation="MLSETASLKKQKTGVLRFLCQAIEAFSFYFRTRSLSFLSFLIDT MNLYMEIFGKVYDADSFLSPSFPYVIYATLCVF*" /label="protein remnant CDS" gene complement(1202129..1202362) /locus_tag="BSU_11798" /old_locus_tag="BSU11798" /pseudo /label="gene" upshifts complement(1202136) /Source="Nicolas_upshifts" /id="U954" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=1256 /SigmaFactorBS="atgatgctgattcatttttgtccccttcctttcCTTATGTCA TatatgctactttaTGCGTATTCTGACAGAAAGTtgctggtggtaacgccttattctt g" /listShort="S422" /listLong="cotV, cotW, S421, cotX" /label="upshifts" S_feature 1202137..1202323 /Source="Nicolas_S_feature" /locus_tag="new_1252566_1252752" /HighExp="S8, S6, S7, BT, S5, B36, S4, S3, G/S, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.26970100000000002" /TUshortSig="SigK, SigEF" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S423" promotor_-10 1202137..1202154 /Source="Nicolas_upshift_promotors" /id="U955" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1353 /SigmaFactorBS="gctcgtatcaaaatggctgcaagaataaggcgttaccACCAG CAACTttctgtcagaataCGCATAAAGTAGCATATAtgacataaggaaaggaagggga c" /listShort="S423, yjzK" /listLong="yjcZ, S424, spoVIF, S425" /label="promotor_-10" upshifts 1202137 /Source="Nicolas_upshifts" /id="U955" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1353 /SigmaFactorBS="gctcgtatcaaaatggctgcaagaataaggcgttaccACCAG CAACTttctgtcagaataCGCATAAAGTAGCATATAtgacataaggaaaggaagggga c" /listShort="S423, yjzK" /listLong="yjcZ, S424, spoVIF, S425" /label="upshifts" promotor_-35 complement(1202154..1202163) /Source="Nicolas_upshift_promotors" /id="U954" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=1256 /SigmaFactorBS="atgatgctgattcatttttgtccccttcctttcCTTATGTCA TatatgctactttaTGCGTATTCTGACAGAAAGTtgctggtggtaacgccttattctt g" /listShort="S422" /listLong="cotV, cotW, S421, cotX" /label="promotor_-35" downshifts complement(1202180) /Source="Nicolas_upshifts" /id="D643" /incds=0 /nref=2 /ntot=13 /MaxReadThrough="3.12564" /MaxDrop="4.58782" /score="-6.14331629" /energy="-6.8" /TU="NA" /idTUdmin="U954" /TUdmin="-528" /isTUend="FALSE" /label="downshifts" downshifts 1202280 /Source="Nicolas_upshifts" /id="D644" /incds=0 /nref=3 /ntot=32 /MaxReadThrough="5.73879" /MaxDrop="3.6919" /score="33.8150878" /energy="-6.8" /TU="U953,U955" /idTUdmin="U953" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" upshifts complement(1202334) /Source="Nicolas_upshifts" /id="U956" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.284715284715285" /psig="0.032967032967033" /xcortree=768 /SigmaFactorBS="ctcattcacttttatccccccgcttatgatatatgctgagcg agaCCGCCTCGttaaaaaaacaaaaaaccggagttctccggtttctttgccaggctat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1202335..1202344 /Source="Nicolas_upshift_promotors" /id="U957" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1288 /SigmaFactorBS="gaaaccggagaactccggttttttgttTTTTTAACGAggcgg tctcgctcAGCATATATCATAAGCGGGGggataaaagtgaatgagtttgaaaaatgga t" /listShort="yjzK, yjcZ, S424, spoVIF, S425" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1202342..1202349) /Source="Nicolas_upshift_promotors" /id="U956" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.284715284715285" /psig="0.032967032967033" /xcortree=768 /SigmaFactorBS="ctcattcacttttatccccccgcttatgatatatgctgagcg agaCCGCCTCGttaaaaaaacaaaaaaccggagttctccggtttctttgccaggctat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 1202358..1202377 /Source="Nicolas_upshift_promotors" /id="U957" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1288 /SigmaFactorBS="gaaaccggagaactccggttttttgttTTTTTAACGAggcgg tctcgctcAGCATATATCATAAGCGGGGggataaaagtgaatgagtttgaaaaatgga t" /listShort="yjzK, yjcZ, S424, spoVIF, S425" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1202368 /Source="Nicolas_upshifts" /id="U957" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1288 /SigmaFactorBS="gaaaccggagaactccggttttttgttTTTTTAACGAggcgg tctcgctcAGCATATATCATAAGCGGGGggataaaagtgaatgagtttgaaaaatgga t" /listShort="yjzK, yjcZ, S424, spoVIF, S425" /GFF_Attribute="listLong" /label="upshifts" CDS 1202386..1202592 /gene="yjzK" /locus_tag="BSU_11799" /old_locus_tag="BSU11799" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097704.1" /db_xref="EnsemblGenomes-Gn:BSU11799" /db_xref="EnsemblGenomes-Tr:CAX52594" /db_xref="UniProtKB/Swiss-Prot:C0H3Y7" /translation="MNEFEKWIEGRYEPHEQKQKEHEDTMGSIRKDLDAFDKAGLEFE DEIEELAEKTEALLKKHQAQYDQS*" /label="yjzK CDS" gene 1202386..1202592 /gene="yjzK" /locus_tag="BSU_11799" /old_locus_tag="BSU11799" /label="yjzK gene" CDS 1202429..1202644 /gene="yjcB" /locus_tag="BSU_11800" /old_locus_tag="BSU11800" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:14523132" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14523132; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sporulation-specific protein" /protein_id="YP_009513951.1" /translation="MNKSKKSMKTRWAVSEKTWMHLIKPVWNLKMRLKSWLKKRRPYL KNIKLNMINRKSANALCEYPSRSQQLT*" /label="yjcB CDS" gene 1202429..1202644 /gene="yjcB" /locus_tag="BSU_11800" /old_locus_tag="BSU11800" /label="yjcB gene" promotor_-35 1202616..1202625 /Source="Nicolas_upshift_promotors" /id="U958" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1409 /SigmaFactorBS="tcaatcgtaaatccgcaaacgccctatgcgaatATCCAAGCC GatcccagcagctCACATAGTGTATAGAGAGTAaaggaggtgcttatctatgggcttt g" /listShort="yjcZ, S424, spoVIF, S425" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1202638..1202657 /Source="Nicolas_upshift_promotors" /id="U958" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1409 /SigmaFactorBS="tcaatcgtaaatccgcaaacgccctatgcgaatATCCAAGCC GatcccagcagctCACATAGTGTATAGAGAGTAaaggaggtgcttatctatgggcttt g" /listShort="yjcZ, S424, spoVIF, S425" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1202643 /Source="Nicolas_upshifts" /id="U958" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1409 /SigmaFactorBS="tcaatcgtaaatccgcaaacgccctatgcgaatATCCAAGCC GatcccagcagctCACATAGTGTATAGAGAGTAaaggaggtgcttatctatgggcttt g" /listShort="yjcZ, S424, spoVIF, S425" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1202650..1202664) /Source="Nicolas_upshift_promotors" /id="U959" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=690 /SigmaFactorBS="gccataacagccgccgccgtagccgccgccgaatccgtatcc aaagCCCATagataagcaCCTCCTTTACTCTCTatacactatgtgagctgctgggatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1202664) /Source="Nicolas_upshifts" /id="U959" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=690 /SigmaFactorBS="gccataacagccgccgccgtagccgccgccgaatccgtatcc aaagCCCATagataagcaCCTCCTTTACTCTCTatacactatgtgagctgctgggatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1202674..1202678) /Source="Nicolas_upshift_promotors" /id="U959" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=690 /SigmaFactorBS="gccataacagccgccgccgtagccgccgccgaatccgtatcc aaagCCCATagataagcaCCTCCTTTACTCTCTatacactatgtgagctgctgggatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1202674..1202823 /gene="yjcZ" /locus_tag="BSU_11809" /old_locus_tag="BSU11809" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14523132, 20156992, 21670523; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative type I toxin" /protein_id="YP_003097705.1" /db_xref="EnsemblGenomes-Gn:BSU11809" /db_xref="EnsemblGenomes-Tr:CAX52595" /db_xref="GOA:C0H3Y8" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/Swiss-Prot:C0H3Y8" /translation="MGFGYGFGGGYGGGCYGGYAGGYGGGYGSTFVLLVVLFILLIIV GASFF*" /label="yjcZ CDS" gene 1202674..1202823 /gene="yjcZ" /locus_tag="BSU_11809" /old_locus_tag="BSU11809" /label="yjcZ gene" downshifts 1202764 /Source="Nicolas_upshifts" /id="D645" /incds=0 /nref=4 /ntot=29 /MaxReadThrough="8.16203" /MaxDrop="4.48861" /score="1.53429015" /energy="-22.4" /TU="U957,U958" /idTUdmin="U955" /TUdmin=110 /isTUend="FALSE" /label="downshifts" S_feature 1202824..1202955 /Source="Nicolas_S_feature" /locus_tag="new_1253253_1253384" /HighExp="S7, BT, S8, B36, S6, G/S, Pyr, B60, S5, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigK" /TUshortPSig="1, 0.971" /TUlongSig="SigK, SigEF" /TUlongPSig="0.999, 1" /label="S424" CDS 1202956..1203210 /gene="spoVIF" /locus_tag="BSU_11810" /old_locus_tag="BSU11810" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:14523132, 14702409, 20435725" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14523132, 14702409, 20435725; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sporulation-specific protein needed for heat resistance" /protein_id="NP_389063.2" /db_xref="EnsemblGenomes-Gn:BSU11810" /db_xref="EnsemblGenomes-Tr:CAB13038" /db_xref="GOA:O31625" /db_xref="InterPro:IPR025942" /db_xref="SubtiList:BG13156" /db_xref="UniProtKB/Swiss-Prot:O31625" /translation="MDNQFFKNIEKKTGVKMQDVMNLAGSLQNANFKDENTVRSVINR VAQMANRRVPKELEDKIVESITSGKEKLDFGTISKMMDNK*" /label="spoVIF CDS" gene 1202956..1203210 /gene="spoVIF" /locus_tag="BSU_11810" /old_locus_tag="BSU11810" /label="spoVIF gene" downshifts 1203195 /Source="Nicolas_upshifts" /id="D646" /incds=0 /nref=40 /ntot=79 /MaxReadThrough="5.66609" /MaxDrop="5.8411" /score="7.68851688" /energy="-10.7" /TU="U957,U958" /idTUdmin="U955" /TUdmin=541 /isTUend="FALSE" /label="downshifts" downshifts complement(1203214) /Source="Nicolas_upshifts" /id="D647" /incds=0 /nref=3 /ntot=9 /MaxReadThrough="3.12148" /MaxDrop="4.34051" /score="24.4726468" /energy="-14.3" /TU="NA" /idTUdmin="U961" /TUdmin=88 /isTUend="FALSE" /label="downshifts" S_feature 1203240..1204340 /Source="Nicolas_S_feature" /locus_tag="new_1253669_1254769" /HighExp="S8, S6, S7, B36, S5, C30, BT, dia15, Diami, H2O2" /AntisenseName="yjcD" /AntisenseCor="-0.210610370451118" /AntisenseRegPval="-3.3" /CDS_PredictionProba="0.18426200000000001" /TUshortSig="SigK, SigK" /TUshortPSig="1, 0.971" /TUlongSig="SigK, SigEF" /TUlongPSig="0.999, 1" /label="S425" CDS complement(1203284..1205563) /gene="yjcD" /locus_tag="BSU_11820" /old_locus_tag="BSU11820" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11544244, 16014871, 17114254, 22933559; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ATP-dependent DNA helicase (sporulationassociated)" /protein_id="NP_389064.3" /db_xref="EnsemblGenomes-Gn:BSU11820" /db_xref="EnsemblGenomes-Tr:CAB13039" /db_xref="GOA:O31626" /db_xref="InterPro:IPR000212" /db_xref="InterPro:IPR014016" /db_xref="InterPro:IPR014017" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR034739" /db_xref="SubtiList:BG13157" /db_xref="UniProtKB/Swiss-Prot:O31626" /translation="MKCARLNDRIIHLHTYSREHYQFLFEEGIKGHLFCSHCGKPVLL RLNIADPPEFIHRQPGDFPACEEACEPKPSKEGKKEDDQESGVIRLPKGKAIAADPSP AVTEWHRPRSIKPGTPFVPKTIEPDTSLFPSVGLNTDQLKAVTETEGPLLVLAGAGSG KTRVLTARAAHMIEHLGIPPENMLLVTFTTKAVAEMKERMANQYGLQPAKVRRIVTGT FHSLFYKILYHSNSAKWNGEHLLKMEWQREQYIKKALYEEGIDEKESPVDQALQQIGF WKNTYVPNERIPLKDEWEKQVYRLYEHYERQKKEHSQFDFDDMASACYELFIERPDLL EQYQSRFTYILIDEFQDINPVQYKIMQMLASPEQNLCCVGDDDQSIYAFRGSNPSFIL DFQKDYPGAKTIYLTANYRSTHPIVSSADIVVKKNKNRYAKTLEAARDDIQVPVLFYP YDEEEEATMVVSDIKEKIQNGASPEDFAVLYRTNSGGRAIYERLHQSSIPYTADRGVQ SFYSRRIVRQILAYLYASQNEDDTEAIKHLLPALFLKQSALNTLKALSITEDCTMIKA LAKLPDLKPFQLDKIKKIVPFFASLRTMKPVEAITFAEGKMGFSEYLKKRGNEGNKLE KGSDDLRDIKVVAKKFKTIPDFLAHVDHMRAAEKNRTDEHGVQLMTIHRSKGLEFKTV YVLGTVDGSIPHDFSLETARKGDEAALEEERRLLYVAMTRAKQHLYLSCPANRRGKTA NRSRFLYPLLQKARQPLHH*" /label="yjcD CDS" gene complement(1203284..1205563) /gene="yjcD" /locus_tag="BSU_11820" /old_locus_tag="BSU11820" /label="yjcD gene" downshifts complement(1203302) /Source="Nicolas_upshifts" /id="D648" /incds=0 /nref=61 /ntot=171 /MaxReadThrough="2.59869" /MaxDrop="4.36061" /score="24.4726468" /energy="-14.3" /TU="NA" /idTUdmin="U961" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1205438..1205612) /Source="Nicolas_S_feature" /locus_tag="new_1255867_1256041_c" /HighExp="G180, G135, G150, H2O2, Paraq, Oxctl, LBGexp, dia15, dia0, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S426" promotor_-35 1205491..1205499 /Source="Nicolas_upshift_promotors" /id="U960" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.868131868131868" /psig="0.868131868131868" /xcortree=958 /SigmaFactorBS="tgagaacaaaataaatgtccttttattccctcttcaaAGAGG AATTgataatgttcTCTCGAATATGTATGTAAAtgtatgattctatcattcagtcggg c" /listShort="S427, yjzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1205510..1205528 /Source="Nicolas_upshift_promotors" /id="U960" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.868131868131868" /psig="0.868131868131868" /xcortree=958 /SigmaFactorBS="tgagaacaaaataaatgtccttttattccctcttcaaAGAGG AATTgataatgttcTCTCGAATATGTATGTAAAtgtatgattctatcattcagtcggg c" /listShort="S427, yjzE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1205514..1205649 /Source="Nicolas_S_feature" /locus_tag="new_1255943_1256078" /HighExp="S4, S5, S3, S6, S7, S8, M9-stat, T4.0H, T3.0H, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig="0.868" /TUlongSig="NA" /TUlongPSig="NA" /label="S427" upshifts 1205514 /Source="Nicolas_upshifts" /id="U960" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.868131868131868" /psig="0.868131868131868" /xcortree=958 /SigmaFactorBS="tgagaacaaaataaatgtccttttattccctcttcaaAGAGG AATTgataatgttcTCTCGAATATGTATGTAAAtgtatgattctatcattcagtcggg c" /listShort="S427, yjzE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1205600..1205619) /Source="Nicolas_upshift_promotors" /id="U961" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2545 /SigmaFactorBS="cacccctctgctgtctcttttcccttaaacttACTTTttgaa acacatttctTTTGATATGATAGTCATTGTctgtaatgaacaccttttgattgggagg a" /listShort="S426, yjcD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1205611) /Source="Nicolas_upshifts" /id="U961" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2545 /SigmaFactorBS="cacccctctgctgtctcttttcccttaaacttACTTTttgaa acacatttctTTTGATATGATAGTCATTGTctgtaatgaacaccttttgattgggagg a" /listShort="S426, yjcD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1205627..1205633 /Source="Nicolas_upshift_promotors" /id="U962" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=197 /SigmaFactorBS="tcattacagacaatgactatcatatcaaaagaaatgTGTTTC AaaaagtaagtttaaGGGAAAAGAGACAGCAGAGgggtgggtattgtatgatatatgc a" /listShort="yjzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(1205635..1205639) /Source="Nicolas_upshift_promotors" /id="U961" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2545 /SigmaFactorBS="cacccctctgctgtctcttttcccttaaacttACTTTttgaa acacatttctTTTGATATGATAGTCATTGTctgtaatgaacaccttttgattgggagg a" /listShort="S426, yjcD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1205648..1205666 /Source="Nicolas_upshift_promotors" /id="U962" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=197 /SigmaFactorBS="tcattacagacaatgactatcatatcaaaagaaatgTGTTTC AaaaagtaagtttaaGGGAAAAGAGACAGCAGAGgggtgggtattgtatgatatatgc a" /listShort="yjzE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1205651 /Source="Nicolas_upshifts" /id="U962" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=197 /SigmaFactorBS="tcattacagacaatgactatcatatcaaaagaaatgTGTTTC AaaaagtaagtttaaGGGAAAAGAGACAGCAGAGgggtgggtattgtatgatatatgc a" /listShort="yjzE" /GFF_Attribute="listLong" /label="upshifts" CDS 1205680..1205934 /gene="yjzE" /locus_tag="BSU_11839" /old_locus_tag="BSU11839" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 11976315, 23155385" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097706.1" /db_xref="EnsemblGenomes-Gn:BSU11839" /db_xref="EnsemblGenomes-Tr:CAX52596" /db_xref="UniProtKB/Swiss-Prot:C0H3Y9" /translation="MIYAGQIQNQQYAQYANRTIGHKQDYAGTEKISYVPFQRVYKEL EKQQENQTAAERKVNEMKRKRSLYKRLREKGMGTYINRYV*" /label="yjzE CDS" gene 1205680..1205934 /gene="yjzE" /locus_tag="BSU_11839" /old_locus_tag="BSU11839" /label="yjzE gene" downshifts 1205910 /Source="Nicolas_upshifts" /id="D649" /incds=0 /nref=101 /ntot=248 /MaxReadThrough="3.69482" /MaxDrop="7.80206" /score="5.37568515" /energy="-6.1" /TU="U962" /idTUdmin="U960" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1206000) /Source="Nicolas_upshifts" /id="D650" /incds=0 /nref=78 /ntot=283 /MaxReadThrough="3.21062" /MaxDrop="7.8562" /score="-4.05705392" /energy="-6.1" /TU="U963" /idTUdmin="U963" /TUdmin="-36" /isTUend="FALSE" /label="downshifts" CDS complement(1206007..1206429) /gene="yjcF" /locus_tag="BSU_11840" /old_locus_tag="BSU11840" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_389066.1" /db_xref="EnsemblGenomes-Gn:BSU11840" /db_xref="EnsemblGenomes-Tr:CAB13041" /db_xref="GOA:O31628" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="PDB:1Q2Y" /db_xref="SubtiList:BG13159" /db_xref="UniProtKB/Swiss-Prot:O31628" /translation="MKAVIAKNEEQLKDAFYVREEVFVKEQNVPAEEEIDELENESEH IVVYDGEKPVGAGRWRMKDGYGKLERICVLKSHRSAGVGGIIMKALEKAAADGGASGF ILNAQTQAVPFYKKHGYRVLSEKEFLDAGIPHLQMMKD*" /label="yjcF CDS" gene complement(1206007..1206429) /gene="yjcF" /locus_tag="BSU_11840" /old_locus_tag="BSU11840" /label="yjcF gene" CDS complement(1206433..1206948) /gene="yjcG" /locus_tag="BSU_11850" /old_locus_tag="BSU11850" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12466548, 16511078, 17012785, 18473364, 25643072; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA ligase or phosphoesterase" /protein_id="NP_389067.1" /db_xref="EnsemblGenomes-Gn:BSU11850" /db_xref="EnsemblGenomes-Tr:CAB13042" /db_xref="GOA:O31629" /db_xref="InterPro:IPR009097" /db_xref="InterPro:IPR022932" /db_xref="PDB:2D4G" /db_xref="SubtiList:BG13160" /db_xref="UniProtKB/Swiss-Prot:O31629" /translation="MKYGIVLFPSKKLQDLANSYRKRYDPSYSLIPPHLTLRASFECA EEKADQLVSHLRNIAKESHPLVLKMTKYSSFAPVNNVIYIKAEPTEELKTLNEKLYTG VLAGEQEYNFVPHVTVGQNLSDDEHSDVLGQLKMQEVSHEEIVDRFHLLYQLENGSWT VYETFLLGRGE*" /label="yjcG CDS" gene complement(1206433..1206948) /gene="yjcG" /locus_tag="BSU_11850" /old_locus_tag="BSU11850" /label="yjcG gene" CDS complement(1206985..1207707) /gene="yjcH" /locus_tag="BSU_11860" /old_locus_tag="BSU11860" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20941576; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative stress-related hydrolase" /protein_id="NP_389068.1" /db_xref="EnsemblGenomes-Gn:BSU11860" /db_xref="EnsemblGenomes-Tr:CAB13043" /db_xref="InterPro:IPR000801" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG13161" /db_xref="UniProtKB/Swiss-Prot:O31630" /translation="MAPKNGTVQEKKFFSKELNEEMTLLVYLPSNYSPLYKYHVIIAQ DGHDYFRLGRIGRQVEELLSKREIDRSIIIGVPYKDVKERRNTYHPEGSKFSAYKRFI AHELVPFADDEYPTYQIGYGRTLIGDSLGATVSLMTALDYPNMFGNIIMQSPYVDKHV LEAVKQSDDIKHLSIYHQIGTKETDVHTTDGNILDFTEPNRELKQLLEKKLSDYDFEP FDGDHKWTYWQPLITPALKKML*" /label="yjcH CDS" gene complement(1206985..1207707) /gene="yjcH" /locus_tag="BSU_11860" /old_locus_tag="BSU11860" /label="yjcH gene" misc_feature complement(1207746..1207765) /Source="Nicolas_upshift_promotors" /id="U963" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2938 /SigmaFactorBS="tttatttcaacacttttttcttcgtgtgccgaaccgtttaaa gagagaaatttctaataattCATGGTACAATAATTGAAAAtgcaagaaagtatagtga t" /listShort="yjcH, yjcG, yjcF" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1207767) /Source="Nicolas_upshifts" /id="U963" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2938 /SigmaFactorBS="tttatttcaacacttttttcttcgtgtgccgaaccgtttaaa gagagaaatttctaataattCATGGTACAATAATTGAAAAtgcaagaaagtatagtga t" /listShort="yjcH, yjcG, yjcF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1207816..1207823 /Source="Nicolas_upshift_promotors" /id="U964" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2887 /SigmaFactorBS="tctctttaaacggttcggcacacgaagaaaaaagTGTTGAAA taaactgtgaattgCGCTAATATAAAACAATCAGaaaattgaaatcgatatttcttat c" /listShort="NA, metI, metC, S428" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1207838..1207857 /Source="Nicolas_upshift_promotors" /id="U964" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2887 /SigmaFactorBS="tctctttaaacggttcggcacacgaagaaaaaagTGTTGAAA taaactgtgaattgCGCTAATATAAAACAATCAGaaaattgaaatcgatatttcttat c" /listShort="NA, metI, metC, S428" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1207842 /Source="Nicolas_upshifts" /id="U964" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2887 /SigmaFactorBS="tctctttaaacggttcggcacacgaagaaaaaagTGTTGAAA taaactgtgaattgCGCTAATATAAAACAATCAGaaaattgaaatcgatatttcttat c" /listShort="NA, metI, metC, S428" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 1207875..1207995 /gene="mswA" /locus_tag="BSU_misc_RNA_15" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /function="16.3: Control" /label="mswA RNA" gene 1207875..1207995 /gene="mswA" /locus_tag="BSU_misc_RNA_15" /label="mswA gene" downshifts 1208000 /Source="Nicolas_upshifts" /id="D651" /incds=0 /nref=8 /ntot=59 /MaxReadThrough="7.71668" /MaxDrop="5.0477" /score="31.1477774" /energy="-15.2" /TU="U964" /idTUdmin="U962" /TUdmin=2024 /isTUend="FALSE" /label="downshifts" CDS 1208063..1209184 /gene="metI" /locus_tag="BSU_11870" /old_locus_tag="BSU11870" /EC_number="2.5.1.49" /EC_number="2.5.1.48" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 11832514, 22938038" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11832514, 22938038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cystathionine gamma-synthase and O-acetylhomoserine thiolyase" /protein_id="NP_389069.1" /db_xref="EnsemblGenomes-Gn:BSU11870" /db_xref="EnsemblGenomes-Tr:CAB13044" /db_xref="GOA:O31631" /db_xref="InterPro:IPR000277" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG13162" /db_xref="UniProtKB/Swiss-Prot:O31631" /translation="MSQHVETKLAQIGNRSDEVTGTVSAPIYLSTAYRHRGIGESTGF DYVRTKNPTRQLVEDAIANLENGARGLAFSSGMAAIQTIMALFKSGDELIVSSDLYGG TYRLFENEWKKYGLTFHYDDFSDEDCLRSKITPNTKAVFVETPTNPLMQEADIEHIAR ITKEHGLLLIVDNTFYTPVLQRPLELGADIVIHSATKYLGGHNDLLAGLVVVKDERLG EEMFQHQNAIGAVLPPFDSWLLMRGMKTLSLRMRQHQANAQELAAFLEEQEEISDVLY PGKGGMLSFRLQKEEWVNPFLKALKTICFAESLGGVESFITYPATQTHMDIPEEIRIA NGVCNRLLRFSVGIEHAEDLKEDLKQALCQVKEGAVSFE*" /label="metI CDS" gene 1208063..1209184 /gene="metI" /locus_tag="BSU_11870" /old_locus_tag="BSU11870" /label="metI gene" CDS 1209177..1210349 /gene="metC" /locus_tag="BSU_11880" /old_locus_tag="BSU11880" /EC_number="4.4.1.8" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 11832514, 11948165, 15760717" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11832514, 11948165, 15760717; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cystathionine beta-lyase" /protein_id="NP_389070.1" /db_xref="EnsemblGenomes-Gn:BSU11880" /db_xref="EnsemblGenomes-Tr:CAB13045" /db_xref="GOA:O31632" /db_xref="InterPro:IPR000277" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG13163" /db_xref="UniProtKB/Swiss-Prot:O31632" /translation="MSKHNWTLETQLVHNPFKTDGGTGAVSVPIQHASTFHQSSFEEF GAYDYSRSGTPTRTALEETIAALEGGTRGFAFSSGMAAISTAFLLLSQGDHVLVTEDV YGGTFRMVTEVLTRFGIEHTFVDMTDRNEVARSIKPNTKVIYMETPSNPTLGITDIKA VVQLAKENGCLTFLDNTFMTPALQRPLDLGVDIVLHSATKFLSGHSDVLSGLAAVKDE ELGKQLYKLQNAFGAVLGVQDCWLVLRGLKTLQVRLEKASQTAQRLAEFFQKHPAVKR VYYPGLADHPGAETHKSQSTGAGAVLSFELESKEAVKKLVENVSLPVFAVSLGAVESI LSYPATMSHAAMPKEEREKRGITDGLLRLSVGVEHADDLEHDFEQALKEIAPVSVR*" /label="metC CDS" gene 1209177..1210349 /gene="metC" /locus_tag="BSU_11880" /old_locus_tag="BSU11880" /label="metC gene" downshifts 1210332 /Source="Nicolas_upshifts" /id="D652" /incds=0 /nref=108 /ntot=205 /MaxReadThrough="4.73188" /MaxDrop="5.54268" /score="4.00424187" /energy="-9.2" /TU="U964" /idTUdmin="U964" /TUdmin="-1474" /isTUend="FALSE" /label="downshifts" misc_feature 1210366..1210384 /Source="Nicolas_upshift_promotors" /id="U965" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.671328671328671" /psig="0.671328671328671" /xcortree=2911 /SigmaFactorBS="gctgaaagaaattgctccagtttcggttcgttaaaaaagaag ccggggatAGTCCGGCTTCTTTTATTAttgttcgtcatcaggattcagaatcgcgagg a" /listShort="S428" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1210376 /Source="Nicolas_upshifts" /id="U965" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.671328671328671" /psig="0.671328671328671" /xcortree=2911 /SigmaFactorBS="gctgaaagaaattgctccagtttcggttcgttaaaaaagaag ccggggatAGTCCGGCTTCTTTTATTAttgttcgtcatcaggattcagaatcgcgagg a" /listShort="S428" /GFF_Attribute="listLong" /label="upshifts" S_feature 1210377..1211906 /Source="Nicolas_S_feature" /locus_tag="new_1260806_1262335" /HighExp="MG 5, MG t5, MG 10, BMM, GM 25, MG 15, Glu, GM 15, GM 45, GM 10" /AntisenseName="yjcK" /AntisenseCor="0.123731990206979" /AntisenseRegPval="-1.4" /CDS_PredictionProba="NA" /TUshortSig="SigL, SigA" /TUshortPSig="0.671, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S428" CDS complement(1210382..1210927) /gene="yjcK" /locus_tag="BSU_11890" /old_locus_tag="BSU11890" /EC_number="2.3.1.267" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 2828880; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ribosomal-protein-alanine N-acetyltransferase" /protein_id="NP_389071.1" /db_xref="EnsemblGenomes-Gn:BSU11890" /db_xref="EnsemblGenomes-Tr:CAB13046" /db_xref="GOA:O31633" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13164" /db_xref="UniProtKB/Swiss-Prot:O31633" /translation="MLKGKTIYVRPLEVTDAEENLGLQSENRDFFEQFSMIRADDYYT VEGQRKRITEYQERLEKDEEYHFGIFTASDDRLIGTVSLFQIIRGALQTAFIGYFLDK AHNGKGIMTEAVRLVVDYAFHELKLHRIEAGVMPRNLGSMRVLEKAGFHKEGIARKNV KINGVWEDHQVLAILNPDDEQ*" /label="yjcK CDS" gene complement(1210382..1210927) /gene="yjcK" /locus_tag="BSU_11890" /old_locus_tag="BSU11890" /label="yjcK gene" downshifts complement(1210403) /Source="Nicolas_upshifts" /id="D653" /incds=0 /nref=14 /ntot=127 /MaxReadThrough="0.4032" /MaxDrop="4.23858" /score="-7.12102596" /energy="-7.3" /TU="NA" /idTUdmin="U966" /TUdmin="-17" /isTUend="TRUE" /label="downshifts" CDS complement(1210997..1212187) /gene="yjcL" /locus_tag="BSU_11900" /old_locus_tag="BSU11900" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein; possibly aquaporin-related" /protein_id="NP_389072.1" /db_xref="EnsemblGenomes-Gn:BSU11900" /db_xref="EnsemblGenomes-Tr:CAB13047" /db_xref="GOA:O31634" /db_xref="InterPro:IPR008537" /db_xref="SubtiList:BG13165" /db_xref="UniProtKB/Swiss-Prot:O31634" /translation="MHSLISSDDVWVLWGFIAVWAAVSIGLEQRFKWASAVSGAIIAL AGAMVFTNVGVLPVESPVYDTVWSYVVPLAIPLLLFQINVRQIFKESRRLLFIFLISS VGTVLGSILAFFLLKQHIPYLDKIGGMISASYIGGGVNFAAMAAKFETPGEYVSATVV ADNFMMALLFFILISIPALKWFQRHYAMPFEEKVKADGNSGNSAESYWKRKDISLKDI AFNAGAAFALVAVSMKVSGYFKSIFSHPLLTGTLGDQYLVLTSLTVLIIFLFPRFFER LNGSQELGTFLIYLFFVVIGIPADLRLIVTNAPLILLFVFIIAISNLAVSLAAGKLFR VRLEEILLAVNATVGGPTTAAAMAIAKGWRELVAPIMLVGTLGYLIGNYVGTFMGNWF SSFL*" /label="yjcL CDS" gene complement(1210997..1212187) /gene="yjcL" /locus_tag="BSU_11900" /old_locus_tag="BSU11900" /label="yjcL gene" promotor_-10 complement(1212213..1212232) /Source="Nicolas_upshift_promotors" /id="U966" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.448551448551449" /psig=1 /xcortree=2871 /SigmaFactorBS="ttttttagaaaaactttttttggACTTGCTGttccgttcccc ggcTATTATAATATGTCTTAATTttctaacaatagaggtgatggggttttgcattctt t" /listShort="yjcL, yjcK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1212217) /Source="Nicolas_upshifts" /id="U966" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.448551448551449" /psig=1 /xcortree=2871 /SigmaFactorBS="ttttttagaaaaactttttttggACTTGCTGttccgttcccc ggcTATTATAATATGTCTTAATTttctaacaatagaggtgatggggttttgcattctt t" /listShort="yjcL, yjcK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1212247..1212254) /Source="Nicolas_upshift_promotors" /id="U966" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.448551448551449" /psig=1 /xcortree=2871 /SigmaFactorBS="ttttttagaaaaactttttttggACTTGCTGttccgttcccc ggcTATTATAATATGTCTTAATTttctaacaatagaggtgatggggttttgcattctt t" /listShort="yjcL, yjcK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1212281..1212288 /Source="Nicolas_upshift_promotors" /id="U967" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.85914085914086" /psig=1 /xcortree=2414 /SigmaFactorBS="agccggggaacggaacagcaagtccaaaaaaagtttttctaa aaaagcaGTTGACGAatagaaggtaaggTTATATAATAGAACTTGTCAgaaagataac a" /listShort="trnSL-Val2, S430" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1212292 /Source="Nicolas_upshifts" /id="U967" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.85914085914086" /psig=1 /xcortree=2414 /SigmaFactorBS="agccggggaacggaacagcaagtccaaaaaaagtttttctaa aaaagcaGTTGACGAatagaaggtaaggTTATATAATAGAACTTGTCAgaaagataac a" /listShort="trnSL-Val2, S430" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1212302..1212321 /Source="Nicolas_upshift_promotors" /id="U967" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.85914085914086" /psig=1 /xcortree=2414 /SigmaFactorBS="agccggggaacggaacagcaagtccaaaaaaagtttttctaa aaaagcaGTTGACGAatagaaggtaaggTTATATAATAGAACTTGTCAgaaagataac a" /listShort="trnSL-Val2, S430" /GFF_Attribute="listLong" /label="promotor_-10" tRNA 1212360..1212432 /gene="trnSL-Val2" /locus_tag="BSU_tRNA_83" /product="tRNA-Val" /inference="profile:tRNAscan:1.23" /note="valine tRNA (GAC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Val2 tRNA" gene 1212360..1212432 /gene="trnSL-Val2" /locus_tag="BSU_tRNA_83" /label="trnSL-Val2 gene" promotor_-10 complement(1212374..1212391) /Source="Nicolas_upshift_promotors" /id="U968" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.926073926073926" /psig="0.007992007992008" /xcortree=394 /SigmaFactorBS="gcaagggtttaagctatgattccgactgggCTCGAACcagcg acctctaccctgtcaAGGTAGCGCTCTCCCAGCtgagctacggaatcatgatatgtat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1212388) /Source="Nicolas_upshifts" /id="U968" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.926073926073926" /psig="0.007992007992008" /xcortree=394 /SigmaFactorBS="gcaagggtttaagctatgattccgactgggCTCGAACcagcg acctctaccctgtcaAGGTAGCGCTCTCCCAGCtgagctacggaatcatgatatgtat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1212412..1212418) /Source="Nicolas_upshift_promotors" /id="U968" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.926073926073926" /psig="0.007992007992008" /xcortree=394 /SigmaFactorBS="gcaagggtttaagctatgattccgactgggCTCGAACcagcg acctctaccctgtcaAGGTAGCGCTCTCCCAGCtgagctacggaatcatgatatgtat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1212422 /Source="Nicolas_upshifts" /id="D654" /incds=0 /nref=17 /ntot=80 /MaxReadThrough="4.64061" /MaxDrop="5.10012" /score="20.8247903" /energy="-9.1" /TU="U967" /idTUdmin="U965" /TUdmin=550 /isTUend="FALSE" /label="downshifts" S_feature complement(1212447..1213182) /Source="Nicolas_S_feature" /locus_tag="new_1262876_1263611_c" /HighExp="M9-stat, Lbstat, M0t90, Pyr, T0.30H, M40t90, C30, S1, LPhT, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S429" S_feature 1212467..1214115 /Source="Nicolas_S_feature" /locus_tag="new_1262896_1264544" /HighExp="Cold, C30, G135, G180, G150, Oxctl, Fru, HPh, Glu, UNK1" /AntisenseName="yjcM" /AntisenseCor="0.46809452811910301" /AntisenseRegPval="-15.3" /CDS_PredictionProba="0.27514300000000003" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S430" downshifts complement(1212476) /Source="Nicolas_upshifts" /id="D655" /incds=0 /nref=29 /ntot=192 /MaxReadThrough="1.23936" /MaxDrop="3.57085" /score="-4.98447688" /energy="-7.9" /TU="NA" /idTUdmin="U970" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1213184..1213272) /Source="Nicolas_S_feature" /locus_tag="new_1263613_1263701_c" /HighExp="aero, HPh, M0t45, SMM, dia0, GM 150, Mal, M/G, Mt0, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S431" downshifts complement(1213227) /Source="Nicolas_upshifts" /id="D656" /incds=0 /nref=34 /ntot=148 /MaxReadThrough="4.13737" /MaxDrop="4.5557" /score="11.73443" /energy="-14.2" /TU="U970" /idTUdmin="U970" /TUdmin="-751" /isTUend="FALSE" /label="downshifts" CDS complement(1213273..1214502) /gene="yjcM" /locus_tag="BSU_11910" /old_locus_tag="BSU11910" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20011599" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; phage island" /protein_id="NP_389073.1" /db_xref="EnsemblGenomes-Gn:BSU11910" /db_xref="EnsemblGenomes-Tr:CAB13048" /db_xref="InterPro:IPR024301" /db_xref="SubtiList:BG13166" /db_xref="UniProtKB/Swiss-Prot:O31635" /translation="MKKELLASLVLCLSLSPLVSTNEVFAATTNKETKENVSITNEIG YEKVKDMLEQQKYDFEHNTPLAHPKESKLTDSDEGVLLYSALSKVDKQKFHEFTYDID DVKTSEKNNKLIVEAYITRNFVFGVEKVTTSLGDNIKLEIPKTTSNKQSSQSTNTSNL SFSQVKNSSNQLNVIPLSNSSKQLNVTQLNNSSSTLQYENDEEYSSDVKLDEFLKKYK QEVKNDDKEEVKSEDKPVSMNFNAANSNQLTVTATSVKGYSGYAAMKYAEKYALKPNK NYKYYKDKDCTNFVSQALRAGRMPYFKEWKPYTDAWVNAGAFRSYILKAGGIKMKTVS DTYSNVKLGDVYHYDYHNKIGLRYADGWMDHTAIVTSRANMKLYVSYHSTNRLNVPRE YVTSKEGGKRYVSSIRN*" /label="yjcM CDS" gene complement(1213273..1214502) /gene="yjcM" /locus_tag="BSU_11910" /old_locus_tag="BSU11910" /label="yjcM gene" downshifts complement(1213395) /Source="Nicolas_upshifts" /id="D657" /incds=1 /nref=4 /ntot=143 /MaxReadThrough="5.58558" /MaxDrop="3.45178" /score="11.73443" /energy="-14.2" /TU="U970" /idTUdmin="U970" /TUdmin="-919" /isTUend="FALSE" /label="downshifts" downshifts 1214072 /Source="Nicolas_upshifts" /id="D658" /incds=1 /nref=1 /ntot=48 /MaxReadThrough="3.19343" /MaxDrop="1.98614" /score="26.2462772" /energy="-24.7" /TU="NA" /idTUdmin="U967" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1214503..1214588) /Source="Nicolas_S_feature" /locus_tag="new_1264932_1265017_c" /HighExp="aero, SMM, T-3.40H, MG 150, Lbexp, SMMPr, GM 90, C90, nit, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S432" promotor_-35 1214543..1214550 /Source="Nicolas_upshift_promotors" /id="U969" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.97902097902098" /psig="0.998001998001998" /xcortree=2298 /SigmaFactorBS="aaatctaaatataagtaatatttatCATTTACAccaattgaa atatgGCATAAAATACATGTAATAAtataacataaaaataaatacataaaaaggtatc g" /listShort="yjcN, S433, yjzF, yjzG, yjcO, S434, yjcP, yjcQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1214565..1214584 /Source="Nicolas_upshift_promotors" /id="U969" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.97902097902098" /psig="0.998001998001998" /xcortree=2298 /SigmaFactorBS="aaatctaaatataagtaatatttatCATTTACAccaattgaa atatgGCATAAAATACATGTAATAAtataacataaaaataaatacataaaaaggtatc g" /listShort="yjcN, S433, yjzF, yjzG, yjcO, S434, yjcP, yjcQ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1214574..1214593) /Source="Nicolas_upshift_promotors" /id="U970" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.320679320679321" /psig="0.999000999001" /xcortree=2299 /SigmaFactorBS="gtataattttagttttctttttcattttttcctccgatacCT TTTTAtgtatttattttTATGTTATATTATTACATGTattttatgccatatttcaatt g" /listShort="S432, yjcM, S431, S429" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1214578 /Source="Nicolas_upshifts" /id="U969" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.97902097902098" /psig="0.998001998001998" /xcortree=2298 /SigmaFactorBS="aaatctaaatataagtaatatttatCATTTACAccaattgaa atatgGCATAAAATACATGTAATAAtataacataaaaataaatacataaaaaggtatc g" /listShort="yjcN, S433, yjzF, yjzG, yjcO, S434, yjcP, yjcQ" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1214592) /Source="Nicolas_upshifts" /id="U970" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.320679320679321" /psig="0.999000999001" /xcortree=2299 /SigmaFactorBS="gtataattttagttttctttttcattttttcctccgatacCT TTTTAtgtatttattttTATGTTATATTATTACATGTattttatgccatatttcaatt g" /listShort="S432, yjcM, S431, S429" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1214606..1214612) /Source="Nicolas_upshift_promotors" /id="U970" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.320679320679321" /psig="0.999000999001" /xcortree=2299 /SigmaFactorBS="gtataattttagttttctttttcattttttcctccgatacCT TTTTAtgtatttattttTATGTTATATTATTACATGTattttatgccatatttcaatt g" /listShort="S432, yjcM, S431, S429" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1214628..1214948 /gene="yjcN" /locus_tag="BSU_11920" /old_locus_tag="BSU11920" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; phage island" /protein_id="NP_389074.1" /db_xref="EnsemblGenomes-Gn:BSU11920" /db_xref="EnsemblGenomes-Tr:CAB13049" /db_xref="SubtiList:BG13167" /db_xref="UniProtKB/Swiss-Prot:O31636" /translation="MKKKTKIILSLLAALIVILIVLPVLSPVVFTASSEKGAIRHEIY KRGYPYQSYFAVLQKREGDNESGNLYYVNWLDWKDETGQTPHLCYSKKSSDGEYEVSC GTGP*" /label="yjcN CDS" gene 1214628..1214948 /gene="yjcN" /locus_tag="BSU_11920" /old_locus_tag="BSU11920" /label="yjcN gene" downshifts 1214958 /Source="Nicolas_upshifts" /id="D659" /incds=0 /nref=57 /ntot=233 /MaxReadThrough="3.73892" /MaxDrop="4.41989" /score="26.2462772" /energy="-24.7" /TU="U969" /idTUdmin="U967" /TUdmin=886 /isTUend="FALSE" /label="downshifts" S_feature 1215003..1215100 /Source="Nicolas_S_feature" /locus_tag="new_1265432_1265529" /HighExp="LoTm, B60, Cold, B36, T3.30H, T3.0H, T4.0H, T2.0H, Sw, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S433" CDS 1215101..1215232 /gene="yjzF" /locus_tag="BSU_11928" /old_locus_tag="BSU11928" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097707.1" /db_xref="EnsemblGenomes-Gn:BSU11928" /db_xref="EnsemblGenomes-Tr:CAX52597" /db_xref="UniProtKB/Swiss-Prot:C0H3Z0" /translation="MKQSKKKPSQKQHERLDRFWQQMMNTNMQTLRRGKGGAYKRRK* " /label="yjzF CDS" gene 1215101..1215232 /gene="yjzF" /locus_tag="BSU_11928" /old_locus_tag="BSU11928" /label="yjzF gene" CDS 1215248..1215421 /gene="yjzG" /locus_tag="BSU_11929" /old_locus_tag="BSU11929" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097708.1" /db_xref="EnsemblGenomes-Gn:BSU11929" /db_xref="EnsemblGenomes-Tr:CAX52598" /db_xref="UniProtKB/Swiss-Prot:C0H3Z1" /translation="MMKNGFAYKNGKLVNIFCGKEELYNELKAFLVKTFSINVKEVSR PSIYRRTKSKQLE*" /label="yjzG CDS" gene 1215248..1215421 /gene="yjzG" /locus_tag="BSU_11929" /old_locus_tag="BSU11929" /label="yjzG gene" CDS 1215458..1215919 /gene="yjcO" /locus_tag="BSU_11930" /old_locus_tag="BSU11930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative DNA binding protein; phage island" /protein_id="NP_389075.1" /db_xref="EnsemblGenomes-Gn:BSU11930" /db_xref="EnsemblGenomes-Tr:CAB13050" /db_xref="GOA:O31637" /db_xref="InterPro:IPR013324" /db_xref="SubtiList:BG13168" /db_xref="UniProtKB/Swiss-Prot:O31637" /translation="MTDQMIAWEIEEWIRDYKFMLREIKRLNRVLNKVDFISTKLTAT YGEEAGMPRGSAGVSQAELRQMDRRERRLHKYESIVHYLDNAMEHIEEEKHRIVYDCM MEGMSYTAIANHLDCSRDTIRKIKTAIIGNIVNKVKEANFLQYLNSFKSAV*" /label="yjcO CDS" gene 1215458..1215919 /gene="yjcO" /locus_tag="BSU_11930" /old_locus_tag="BSU11930" /label="yjcO gene" promotor_-35 1215890..1215897 /Source="Nicolas_upshift_promotors" /id="U971" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.992007992007992" /psig="0.997002997002997" /xcortree=2045 /SigmaFactorBS="aataaagtcaaagaagccaactttctgcaaTATTTGAAttcg tttaaatcggCGGTGTAAAATGGGGGGCAGgatcggcgcggcggattattcctgcgtc a" /listShort="S434" /listLong="yjcP, yjcQ" /label="promotor_-35" promotor_-10 1215912..1215931 /Source="Nicolas_upshift_promotors" /id="U971" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.992007992007992" /psig="0.997002997002997" /xcortree=2045 /SigmaFactorBS="aataaagtcaaagaagccaactttctgcaaTATTTGAAttcg tttaaatcggCGGTGTAAAATGGGGGGCAGgatcggcgcggcggattattcctgcgtc a" /listShort="S434" /listLong="yjcP, yjcQ" /label="promotor_-10" S_feature 1215920..1216160 /Source="Nicolas_S_feature" /locus_tag="new_1266349_1266589" /HighExp="LoTm, B60, Cold, B36, Diami, S8, dia15, C30, dia5, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.12525800000000001" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S434" upshifts 1215920 /Source="Nicolas_upshifts" /id="U971" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.992007992007992" /psig="0.997002997002997" /xcortree=2045 /SigmaFactorBS="aataaagtcaaagaagccaactttctgcaaTATTTGAAttcg tttaaatcggCGGTGTAAAATGGGGGGCAGgatcggcgcggcggattattcctgcgtc a" /listShort="S434" /listLong="yjcP, yjcQ" /label="upshifts" promotor_-35 1216133..1216140 /Source="Nicolas_upshift_promotors" /id="U972" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2836 /SigmaFactorBS="caacagattcgttcgacaaattttgcaaattGTTAATCGata acttttcattCCCGATATTAAAAATGGGAgtgaattgtaaaatgaaaaaacagaaaaa t" /listShort="yjcP, yjcQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1216154..1216172 /Source="Nicolas_upshift_promotors" /id="U972" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2836 /SigmaFactorBS="caacagattcgttcgacaaattttgcaaattGTTAATCGata acttttcattCCCGATATTAAAAATGGGAgtgaattgtaaaatgaaaaaacagaaaaa t" /listShort="yjcP, yjcQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1216162 /Source="Nicolas_upshifts" /id="U972" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2836 /SigmaFactorBS="caacagattcgttcgacaaattttgcaaattGTTAATCGata acttttcattCCCGATATTAAAAATGGGAgtgaattgtaaaatgaaaaaacagaaaaa t" /listShort="yjcP, yjcQ" /GFF_Attribute="listLong" /label="upshifts" CDS 1216185..1216688 /gene="yjcP" /locus_tag="BSU_11940" /old_locus_tag="BSU11940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15033535" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein: phage island" /protein_id="NP_389076.1" /db_xref="EnsemblGenomes-Gn:BSU11940" /db_xref="EnsemblGenomes-Tr:CAB13051" /db_xref="GOA:O31638" /db_xref="SubtiList:BG13169" /db_xref="UniProtKB/Swiss-Prot:O31638" /translation="MKKQKNNKKKNIEKRNIEKRNIEEKNNEDLEELENAIYTYHKKE LLAFFLEKTRIGHDKEEYKRFQSLLYKLDIECLEFAISRFSHIDIIHDHSKYVPAFIP LFAAYLTMFFNFYEKHWGALSFAAGTIAAIVWIIAVERKHRNQAISIMKIFEQVKERK VKDRSKD*" /label="yjcP CDS" gene 1216185..1216688 /gene="yjcP" /locus_tag="BSU_11940" /old_locus_tag="BSU11940" /label="yjcP gene" CDS 1216700..1216984 /gene="yjcQ" /locus_tag="BSU_11950" /old_locus_tag="BSU11950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15033535" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; phage island" /protein_id="NP_389077.1" /db_xref="EnsemblGenomes-Gn:BSU11950" /db_xref="EnsemblGenomes-Tr:CAB13052" /db_xref="InterPro:IPR018597" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2HGC" /db_xref="SubtiList:BG13170" /db_xref="UniProtKB/Swiss-Prot:O31639" /translation="MNKDKLRYAILKEIFEGNTPLSENDIGVTEDQFDDAVNFLKREG YIIGVHYSDDRPHLYKLGPELTEKGENYLKENGTWSKAYKTIKEIKDWIK*" /label="yjcQ CDS" gene 1216700..1216984 /gene="yjcQ" /locus_tag="BSU_11950" /old_locus_tag="BSU11950" /label="yjcQ gene" downshifts 1216954 /Source="Nicolas_upshifts" /id="D660" /incds=0 /nref=215 /ntot=271 /MaxReadThrough="1.63272" /MaxDrop="7.26386" /score="22.0381158" /energy="-7.2" /TU="NA" /idTUdmin="U969" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(1216986) /Source="Nicolas_upshifts" /id="U973" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.828171828171828" /psig="0.107892107892108" /xcortree=80 /SigmaFactorBS="tcctgagacttaccggaagcagtttacagggaacaaaaaaag caccCCGCaggatgctcttattatttaatccaatctttaatctctttaatggtcttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(1216997..1217000) /Source="Nicolas_upshift_promotors" /id="U973" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.828171828171828" /psig="0.107892107892108" /xcortree=80 /SigmaFactorBS="tcctgagacttaccggaagcagtttacagggaacaaaaaaag caccCCGCaggatgctcttattatttaatccaatctttaatctctttaatggtcttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 1217145..1217672 /gene="yjcR" /locus_tag="BSU_11960" /old_locus_tag="BSU11960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7489895, 7704261; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phage-related nucleic acid binding terminase small subunit; phage island" /protein_id="NP_389078.1" /db_xref="EnsemblGenomes-Gn:BSU11960" /db_xref="EnsemblGenomes-Tr:CAB13053" /db_xref="GOA:O31640" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR010332" /db_xref="SubtiList:BG13171" /db_xref="UniProtKB/Swiss-Prot:O31640" /translation="MAEKHIQAYKDYVKGMKYKDLAEKYGVSVNTIKSWKQRHGWERK KGAPIEKSVHTKKGGQPGNKNALGNNGGAPQKNQNAVTHGFFSKFLPEETLEIMEEIQ ERSPADMIWDQIQIQYAAILRAQKIMFVSDKEEMIKELKKKRSLISEVSEIEDGLVIS FSTWFRYRLYSETNT*" /label="yjcR CDS" gene 1217145..1217672 /gene="yjcR" /locus_tag="BSU_11960" /old_locus_tag="BSU11960" /label="yjcR gene" promotor_-35 1217819..1217824 /Source="Nicolas_upshift_promotors" /id="U974" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.748251748251748" /psig="0.992007992007992" /xcortree=2218 /SigmaFactorBS="tacagcgattgattaactcgagcaatcaatgtcgcagttATA TTTatttttcaagaaAATGTTATAATGAAAAGCCAtaaaatgatgggagggggaattt c" /listShort="yjcS, S435, yjdA, S436" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1217837..1217856 /Source="Nicolas_upshift_promotors" /id="U974" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.748251748251748" /psig="0.992007992007992" /xcortree=2218 /SigmaFactorBS="tacagcgattgattaactcgagcaatcaatgtcgcagttATA TTTatttttcaagaaAATGTTATAATGAAAAGCCAtaaaatgatgggagggggaattt c" /listShort="yjcS, S435, yjdA, S436" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1217840 /Source="Nicolas_upshifts" /id="U974" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.748251748251748" /psig="0.992007992007992" /xcortree=2218 /SigmaFactorBS="tacagcgattgattaactcgagcaatcaatgtcgcagttATA TTTatttttcaagaaAATGTTATAATGAAAAGCCAtaaaatgatgggagggggaattt c" /listShort="yjcS, S435, yjdA, S436" /GFF_Attribute="listLong" /label="upshifts" CDS 1217846..1218163 /gene="yjcS" /locus_tag="BSU_11970" /old_locus_tag="BSU11970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; phage island" /protein_id="NP_389079.1" /db_xref="EnsemblGenomes-Gn:BSU11970" /db_xref="EnsemblGenomes-Tr:CAB13054" /db_xref="GOA:O31641" /db_xref="InterPro:IPR007138" /db_xref="InterPro:IPR011008" /db_xref="PDB:1Q8B" /db_xref="SubtiList:BG13172" /db_xref="UniProtKB/Swiss-Prot:O31641" /translation="MKSHKMMGGGISMHYITACLKIISDKDLNEIMKEFKKLEEETNK EEGCITFHAYPLEPSERKIMLWEIWENEEAVKIHFTKKHTIDVQKQELTEVEWLMKSN VND*" /label="yjcS CDS" gene 1217846..1218163 /gene="yjcS" /locus_tag="BSU_11970" /old_locus_tag="BSU11970" /label="yjcS gene" S_feature 1218164..1218399 /Source="Nicolas_S_feature" /locus_tag="new_1268593_1268828" /HighExp="dia5, H2O2, dia15, dia0, Lbexp, Lbtran, C90, Oxctl, S1, aero" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S435" CDS 1218400..1219155 /gene="yjdA" /locus_tag="BSU_11980" /old_locus_tag="BSU11980" /EC_number="1.1.1.-" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 2243795; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyl-carrier protein oxidoreductase; phage island" /protein_id="NP_389080.1" /db_xref="EnsemblGenomes-Gn:BSU11980" /db_xref="EnsemblGenomes-Tr:CAB13055" /db_xref="GOA:O31642" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13173" /db_xref="UniProtKB/Swiss-Prot:O31642" /translation="MSHSQEKIALITGASSQGDIGTAICRKLASQGIHIFFTHWNSDT AWIEEFQQEILRMGVRCEAMKIDLSDAHAAFTIHEKISDKLGYPSILINNAAHSASDN YVSLDAKSLDEHYAVNMRSNFLLCVEFARRFKKSNLISGRIINMTSGQDLGPLPGELA YAATKGAISAFTRSLSQELAPLGITVNAVNPGPTDSTWMTDEIRNFLSPKFPMGRIGT PDDAARMIAFLASDEAEWITGQIIHSEGGFIRG*" /label="yjdA CDS" gene 1218400..1219155 /gene="yjdA" /locus_tag="BSU_11980" /old_locus_tag="BSU11980" /label="yjdA gene" S_feature 1219156..1219243 /Source="Nicolas_S_feature" /locus_tag="new_1269585_1269672" /HighExp="C90, S1, dia0, dia5, Mt0, Lbexp, Gly, H2O2, Oxctl, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S436" downshifts 1219200 /Source="Nicolas_upshifts" /id="D661" /incds=0 /nref=89 /ntot=238 /MaxReadThrough="2.66489" /MaxDrop="5.39812" /score="-0.84766737" /energy="-14.2" /TU="NA" /idTUdmin="U974" /TUdmin="-20" /isTUend="TRUE" /label="downshifts" S_feature complement(1219243..1219303) /Source="Nicolas_S_feature" /locus_tag="new_1269672_1269732_c" /HighExp="Lbstat, BI, BT, nit, S2, ferm, B60, B36, M0t90, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S437" downshifts complement(1219274) /Source="Nicolas_upshifts" /id="D662" /incds=0 /nref=80 /ntot=134 /MaxReadThrough="1.9707" /MaxDrop="7.43843" /score="-5.56180712" /energy="-14.2" /TU="NA" /idTUdmin="U975" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1219304..1219651) /gene="yjdB" /locus_tag="BSU_11990" /old_locus_tag="BSU11990" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16291680; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative exported protein; phage island" /protein_id="NP_389081.1" /db_xref="EnsemblGenomes-Gn:BSU11990" /db_xref="EnsemblGenomes-Tr:CAB13056" /db_xref="InterPro:IPR003343" /db_xref="InterPro:IPR008964" /db_xref="SubtiList:BG13174" /db_xref="UniProtKB/Swiss-Prot:O31643" /translation="MNFKKTVVSALSISALALSVSGVASAHEINSTPTEVKNISISPT HVIKIQDYNLPLKVGETYSVKNNSATRYWTDNQKVAEVDQNGLVTAKSKGKATITLFK GTAVFGKVYVTVY*" /label="yjdB CDS" gene complement(1219304..1219651) /gene="yjdB" /locus_tag="BSU_11990" /old_locus_tag="BSU11990" /label="yjdB gene" promotor_-10 complement(1219683..1219701) /Source="Nicolas_upshift_promotors" /id="U975" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=507 /SigmaFactorBS="tcaattgatcgttcacatattattaacatttatttaCAAGGA AAAtaattactttTATTGAATTGTTATAGTGCaagacaaaaaactttaaaggagtgtt t" /listShort="yjdB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1219696) /Source="Nicolas_upshifts" /id="U975" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=507 /SigmaFactorBS="tcaattgatcgttcacatattattaacatttatttaCAAGGA AAAtaattactttTATTGAATTGTTATAGTGCaagacaaaaaactttaaaggagtgtt t" /listShort="yjdB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1219698..1220154) /Source="Nicolas_S_feature" /locus_tag="new_1270127_1270583_c" /HighExp="T1.30H, T2.0H, T2.30H, T3.0H, M9-stat, T1.0H, Lbstat, T3.30H, M0t90, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.983" /TUlongSig="NA" /TUlongPSig="NA" /label="S438" promotor_-35 complement(1219712..1219720) /Source="Nicolas_upshift_promotors" /id="U975" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=507 /SigmaFactorBS="tcaattgatcgttcacatattattaacatttatttaCAAGGA AAAtaattactttTATTGAATTGTTATAGTGCaagacaaaaaactttaaaggagtgtt t" /listShort="yjdB" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 1220114..1220132 /Source="Nicolas_upshift_promotors" /id="U976" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.33966033966034" /psig="0.99100899100899" /xcortree=1564 /SigmaFactorBS="tttttccggaagcttcggtaaaaaacgaaacttttgtctcta tgatttTGTTTTATAATGTAAACGGtttcttatatagtatacttatactatcaatttg c" /listShort="manR" /listLong="manP, manA, S439, S440, yjdF, yjdI" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1220126 /Source="Nicolas_upshifts" /id="U976" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.33966033966034" /psig="0.99100899100899" /xcortree=1564 /SigmaFactorBS="tttttccggaagcttcggtaaaaaacgaaacttttgtctcta tgatttTGTTTTATAATGTAAACGGtttcttatatagtatacttatactatcaatttg c" /listShort="manR" /listLong="manP, manA, S439, S440, yjdF, yjdI" /label="upshifts" promotor_-10 complement(1220132..1220151) /Source="Nicolas_upshift_promotors" /id="U977" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.572427572427572" /psig="0.983016983016983" /xcortree=327 /SigmaFactorBS="ttatgtattccatctgtttttctatccttcctgtcagtatct ACTTGAGCaaattgatagtatAAGTATACTATATAAGAAACcgtttacattataaaac a" /listShort="S438, yjdB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1220154) /Source="Nicolas_upshifts" /id="U977" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.572427572427572" /psig="0.983016983016983" /xcortree=327 /SigmaFactorBS="ttatgtattccatctgtttttctatccttcctgtcagtatct ACTTGAGCaaattgatagtatAAGTATACTATATAAGAAACcgtttacattataaaac a" /listShort="S438, yjdB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1220165..1220172) /Source="Nicolas_upshift_promotors" /id="U977" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.572427572427572" /psig="0.983016983016983" /xcortree=327 /SigmaFactorBS="ttatgtattccatctgtttttctatccttcctgtcagtatct ACTTGAGCaaattgatagtatAAGTATACTATATAAGAAACcgtttacattataaaac a" /listShort="S438, yjdB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1220202..1222148 /gene="manR" /locus_tag="BSU_12000" /old_locus_tag="BSU12000" /function="16.1: Circulate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10438772, 10960106, 23551403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10438772, 10960106, 23551403; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional DNA-binding activator" /protein_id="NP_389082.2" /db_xref="EnsemblGenomes-Gn:BSU12000" /db_xref="EnsemblGenomes-Tr:CAB13057" /db_xref="GOA:O31644" /db_xref="InterPro:IPR002178" /db_xref="InterPro:IPR007737" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR013011" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR016152" /db_xref="InterPro:IPR036095" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036634" /db_xref="SubtiList:BG13175" /db_xref="UniProtKB/Swiss-Prot:O31644" /translation="MEYINTRQKEILYLLLSEPDDYLVVQDFADRVQCSEKTIRNDLK VIEDYLNEHSHAQLIRKPGLGVYLHIEEQERTWLSQQLHTEHFSSRQRSDKERMLHIA YDLLMNPKPVSAKDIAARHFVNRSSIKKDLYAVEEWLKRFDLTLVSRQRLGLKVEGNE RNKRKALARISDLIHNTAFTSQFIKSKFLHYEVDFVTKEIKSLQKKHSLYFTDETFES LLLHTLLMVRRIKMKQPISLSPKEMAAVKKKKEYQWTFACLQRLEPVFAIRFPEEEAV YLTLHILGGKVRYPLQTEENLENAVLPKVVGHLINRVSELKMMDFHKDQDLINGLNIH LNTVLQRLSYDLSVANPMLNDIKKMYPYLFHLIIDVLEDINQTFDLHIPEEEAAYLTL HFQAAIERMQGSSETHKKAVIVCHMGIGMSQLLRTKIERKYHQIAVMACIAKADLKDY IKKHEDIDLVISTIALENITVPHIVVSPLLEPGEEKKLSAFIRQLGESHRQKQKTFQM LNNTTPFLVFLQQEAEHRYKLIEQLATALFEKGYVDKDYAVHAVMREKMSATNIGSGI AIPHANAKFIKQSAIAIATLKEPLEWGNEKVSLVFMLAVKHEDQTMTKQLFSELSYLS EQPAFVQKLTKETNVMTFLSHLDY*" /label="manR CDS" gene 1220202..1222148 /gene="manR" /locus_tag="BSU_12000" /old_locus_tag="BSU12000" /label="manR gene" downshifts 1222124 /Source="Nicolas_upshifts" /id="D663" /incds=0 /nref=3 /ntot=35 /MaxReadThrough="4.64475" /MaxDrop="3.79938" /score="28.4199725" /energy="-9.1" /TU="U976" /idTUdmin="U976" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" SCAR 1222178..1222179 /note="deletion occured in betwen marked nucleotides" /created_by="User" /label="IIG_Bs02" S_feature <1222179..1222277 /Source="Nicolas_S_feature" /locus_tag="new_1275640_1275738" /HighExp="Oxctl, Lbexp, Paraq, T0.30H, dia0, Diami, H2O2, dia5, Fru, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.15168699999999999" /TUshortSig="SigA" /TUshortPSig="0.936" /TUlongSig="SigA" /TUlongPSig="0.991" /label="S439" promotor_-35 1222252..1222258 /Source="Nicolas_upshift_promotors" /id="U980" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.463536463536464" /psig="0.995004995004995" /xcortree=2151 /SigmaFactorBS="ctattctccagcaatgatctaaataaaataagaGTTTAATag ttggagaagaaaTGTTACACTCTTTTCTGTATatggtaaagaatgaaaaaacacgatt c" /listShort="S440, yjdF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1222273..1222292 /Source="Nicolas_upshift_promotors" /id="U980" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.463536463536464" /psig="0.995004995004995" /xcortree=2151 /SigmaFactorBS="ctattctccagcaatgatctaaataaaataagaGTTTAATag ttggagaagaaaTGTTACACTCTTTTCTGTATatggtaaagaatgaaaaaacacgatt c" /listShort="S440, yjdF" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1222279..1222347 /Source="Nicolas_S_feature" /locus_tag="new_1275740_1275808" /HighExp="Oxctl, Lbexp, Paraq, T0.30H, dia0, Diami, dia5, Fru, H2O2, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.995, 0.936" /TUlongSig="SigA" /TUlongPSig="0.991" /label="S440" upshifts 1222279 /Source="Nicolas_upshifts" /id="U980" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.463536463536464" /psig="0.995004995004995" /xcortree=2151 /SigmaFactorBS="ctattctccagcaatgatctaaataaaataagaGTTTAATag ttggagaagaaaTGTTACACTCTTTTCTGTATatggtaaagaatgaaaaaacacgatt c" /listShort="S440, yjdF" /GFF_Attribute="listLong" /label="upshifts" CDS 1222348..1222830 /gene="yjdF" /locus_tag="BSU_12030" /old_locus_tag="BSU12030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20139185" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389085.1" /db_xref="EnsemblGenomes-Gn:BSU12030" /db_xref="EnsemblGenomes-Tr:CAB13060" /db_xref="InterPro:IPR016787" /db_xref="SubtiList:BG13178" /db_xref="UniProtKB/Swiss-Prot:O31647" /translation="MSVTFPSSGCPSFFNIFYEEGIVMKLTIYYDGQFWVGVVEVVDN GKLRAFRHLFGKEPRDSEVLEFVHNQLLNMMAQAEQEGVRLQGRRQKKINPKRLQRQV SKELKNAGVTSKAQEAIKLELEARKQKKKQIMKEQREHVKEQRYMLKKQKAKKKHRGK *" /label="yjdF CDS" gene 1222348..1222830 /gene="yjdF" /locus_tag="BSU_12030" /old_locus_tag="BSU12030" /label="yjdF gene" downshifts 1222810 /Source="Nicolas_upshifts" /id="D664" /incds=0 /nref=220 /ntot=267 /MaxReadThrough="5.32805" /MaxDrop="7.35641" /score="7.68574519" /energy="-10.2" /TU="U978" /idTUdmin="U980" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(1222876..1223382) /gene="yjdG" /locus_tag="BSU_12040" /old_locus_tag="BSU12040" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_389086.1" /db_xref="EnsemblGenomes-Gn:BSU12040" /db_xref="EnsemblGenomes-Tr:CAB13061" /db_xref="GOA:O31648" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13179" /db_xref="UniProtKB/Swiss-Prot:O31648" /translation="MVLLETNRLRLQTIDIPLLDAASKQDHQAIKELGYETNGEWPNS DFFEAIPYFREILVKNNGTKGFDSWIIVKKDNYEIVGGTGFLGDPDENGMIEIGFATN KSHRRKGYCVEAAQKLINWALSRETVSRITARCEHDNLGSQKTLEKLGFILNHKSAEY KHWIYVTK*" /label="yjdG CDS" gene complement(1222876..1223382) /gene="yjdG" /locus_tag="BSU_12040" /old_locus_tag="BSU12040" /label="yjdG gene" downshifts complement(1222900) /Source="Nicolas_upshifts" /id="D665" /incds=0 /nref=13 /ntot=154 /MaxReadThrough="2.51872" /MaxDrop="4.09551" /score="15.8830125" /energy="-9.9" /TU="NA" /idTUdmin="U984" /TUdmin=7 /isTUend="TRUE" /label="downshifts" misc_feature complement(1223407..1223426) /Source="Nicolas_upshift_promotors" /id="U981" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.654345654345654" /psig="0.775224775224775" /xcortree=679 /SigmaFactorBS="aattttttcatctttctctactgccaaggtaccagagaaaat tgttaTATGTTATCATTATTCCCAGtaaaaagaaaagaggattaaatatatggttctc c" /listShort="yjdG" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1223413) /Source="Nicolas_upshifts" /id="U981" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.654345654345654" /psig="0.775224775224775" /xcortree=679 /SigmaFactorBS="aattttttcatctttctctactgccaaggtaccagagaaaat tgttaTATGTTATCATTATTCCCAGtaaaaagaaaagaggattaaatatatggttctc c" /listShort="yjdG" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1223415..1223600) /Source="Nicolas_S_feature" /locus_tag="new_1276876_1277061_c" /HighExp="S5, S4, S7, S6, S8, B36, LoTm, S3, B60, T1.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.289238" /TUshortSig="SigEF, SigWXY" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S441" CDS complement(1223601..1223996) /gene="yjdH" /locus_tag="BSU_12050" /old_locus_tag="BSU12050" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12562816; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_389087.2" /db_xref="EnsemblGenomes-Gn:BSU12050" /db_xref="EnsemblGenomes-Tr:CAB13062" /db_xref="SubtiList:BG13180" /db_xref="UniProtKB/Swiss-Prot:O31649" /translation="MYHYFYGPALIPYFSHTHNPQRSPDFSERQRRREITLTVDGFVP PSSTEDLGDGFYSYAWTNQQVINPGEYLVCHLEGRDINVINGGFTPRDTAPLYAVASF PRRRNQWVIIIHNPVQTQRAISLYLIAKR*" /label="yjdH CDS" gene complement(1223601..1223996) /gene="yjdH" /locus_tag="BSU_12050" /old_locus_tag="BSU12050" /label="yjdH gene" promotor_-10 complement(1224019..1224037) /Source="Nicolas_upshift_promotors" /id="U982" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1101 /SigmaFactorBS="ctatagcccattattagtctacatggaacaaaacaGGAATGa acaaataactcccACATACAATTTGTATGAATggaaaataaaggagtggttgctttgt a" /listShort="yjdH, S441, yjdG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1224032) /Source="Nicolas_upshifts" /id="U982" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1101 /SigmaFactorBS="ctatagcccattattagtctacatggaacaaaacaGGAATGa acaaataactcccACATACAATTTGTATGAATggaaaataaaggagtggttgctttgt a" /listShort="yjdH, S441, yjdG" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1224034..1224734) /Source="Nicolas_S_feature" /locus_tag="new_1277495_1278195_c" /HighExp="T0.30H, T1.0H, T-0.40H, T1.30H, T0.0H, S0, T2.0H, Salt, T2.30H, T-1.10H" /AntisenseName="yjdI" /AntisenseCor="-0.383915151906285" /AntisenseRegPval="-10.1" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S442" promotor_-35 complement(1224052..1224057) /Source="Nicolas_upshift_promotors" /id="U982" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1101 /SigmaFactorBS="ctatagcccattattagtctacatggaacaaaacaGGAATGa acaaataactcccACATACAATTTGTATGAATggaaaataaaggagtggttgctttgt a" /listShort="yjdH, S441, yjdG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1224140..1224147 /Source="Nicolas_upshift_promotors" /id="U983" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2214 /SigmaFactorBS="tgtccttccgttgattcaatgctagtaaCCTTGAAAatgcag gttaggaTGATAGAATTTACATATTACtgcaagaagttagacatacatcattttgata g" /listShort="yjdI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1224161..1224180 /Source="Nicolas_upshift_promotors" /id="U983" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2214 /SigmaFactorBS="tgtccttccgttgattcaatgctagtaaCCTTGAAAatgcag gttaggaTGATAGAATTTACATATTACtgcaagaagttagacatacatcattttgata g" /listShort="yjdI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1224172 /Source="Nicolas_upshifts" /id="U983" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2214 /SigmaFactorBS="tgtccttccgttgattcaatgctagtaaCCTTGAAAatgcag gttaggaTGATAGAATTTACATATTACtgcaagaagttagacatacatcattttgata g" /listShort="yjdI" /GFF_Attribute="listLong" /label="upshifts" CDS 1224225..1224704 /gene="trnE" /locus_tag="BSU_12060" /old_locus_tag="BSU12060" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 22128149; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cys-tRNApro deacetylase; tRNA editing" /protein_id="NP_389088.1" /db_xref="EnsemblGenomes-Gn:BSU12060" /db_xref="EnsemblGenomes-Tr:CAB13063" /db_xref="GOA:O31650" /db_xref="InterPro:IPR004369" /db_xref="InterPro:IPR007214" /db_xref="InterPro:IPR036754" /db_xref="SubtiList:BG13181" /db_xref="UniProtKB/Swiss-Prot:O31650" /translation="MAKKMAKTNAVRLIEQQNISYEVLGYKTDGQPVDGISVAEKIGY SLKYVYKTLVAAAGTNHYYVFVVPVAEELDVKKAAKVTGEKKIEMIAMKELLAVTGYL RGGCSPIGMKKLFPTYIDASAETLDFIIVSAGKIGMQLKLAPQDLARSCDAAFAEIV* " /label="trnE CDS" gene 1224225..1224704 /gene="trnE" /locus_tag="BSU_12060" /old_locus_tag="BSU12060" /label="trnE gene" downshifts 1224703 /Source="Nicolas_upshifts" /id="D666" /incds=0 /nref=4 /ntot=100 /MaxReadThrough="2.68858" /MaxDrop="3.19616" /score="-5.52314972" /energy="-12.5" /TU="NA" /idTUdmin="U978" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1224744..1224938) /gene="yjzH" /locus_tag="BSU_12069" /old_locus_tag="BSU12069" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097709.1" /db_xref="EnsemblGenomes-Gn:BSU12069" /db_xref="EnsemblGenomes-Tr:CAX52599" /db_xref="InterPro:IPR025234" /db_xref="UniProtKB/Swiss-Prot:C0H3Z2" /translation="MKEYEFVRVELSTMRRRPKEDYQQIIHDYAKRGWRFVQIFAPSI DGYGAAAYFEIIFERDAEKA*" /label="yjzH CDS" gene complement(1224744..1224938) /gene="yjzH" /locus_tag="BSU_12069" /old_locus_tag="BSU12069" /label="yjzH gene" downshifts complement(1224779) /Source="Nicolas_upshifts" /id="D667" /incds=0 /nref=6 /ntot=144 /MaxReadThrough="7.83072" /MaxDrop="2.95935" /score="-6.07514027" /energy="-7" /TU="U984" /idTUdmin="U987" /TUdmin=220 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1224952..1224967) /Source="Nicolas_upshift_promotors" /id="U984" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1698 /SigmaFactorBS="tagtgagtgaaatatactttccgaccttaacctaggttttCG GAACTTCTcgctccattttACGTATACCTTAATAGgagggatcaaacgatgaaagaat a" /listShort="yjzH, S442, yjdH, S441, yjdG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1224968) /Source="Nicolas_upshifts" /id="U984" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1698 /SigmaFactorBS="tagtgagtgaaatatactttccgaccttaacctaggttttCG GAACTTCTcgctccattttACGTATACCTTAATAGgagggatcaaacgatgaaagaat a" /listShort="yjzH, S442, yjdH, S441, yjdG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1224979..1224988) /Source="Nicolas_upshift_promotors" /id="U984" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1698 /SigmaFactorBS="tagtgagtgaaatatactttccgaccttaacctaggttttCG GAACTTCTcgctccattttACGTATACCTTAATAGgagggatcaaacgatgaaagaat a" /listShort="yjzH, S442, yjdH, S441, yjdG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1225104..1225433) /gene="yjdJ" /locus_tag="BSU_12070" /old_locus_tag="BSU12070" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389089.1" /db_xref="EnsemblGenomes-Gn:BSU12070" /db_xref="EnsemblGenomes-Tr:CAB13064" /db_xref="GOA:O31651" /db_xref="InterPro:IPR016508" /db_xref="InterPro:IPR025440" /db_xref="SubtiList:BG13182" /db_xref="UniProtKB/Swiss-Prot:O31651" /translation="MKGIFLVVQLGFSIMVFLFLAAVNWYQGSELVSDRFDWNYTAKL SKLLNGIDAVSSPKQISQLDFFIYSAKHYPVMSALMIISFLYVLAALFLLIYSVKCNK QEIHLDC*" /label="yjdJ CDS" gene complement(1225104..1225433) /gene="yjdJ" /locus_tag="BSU_12070" /old_locus_tag="BSU12070" /label="yjdJ gene" promotor_-10 complement(1225470..1225489) /Source="Nicolas_upshift_promotors" /id="U985" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.428571428571429" /psig="0.994005994005994" /xcortree=3103 /SigmaFactorBS="aaatagacttgcgtttgagttgtatggaagtgaaATTGCAag aataacccatacGGTGGTAATATATTGTTTGAttttcccatattcatagatttggagg t" /listShort="yjdJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1225483) /Source="Nicolas_upshifts" /id="U985" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.428571428571429" /psig="0.994005994005994" /xcortree=3103 /SigmaFactorBS="aaatagacttgcgtttgagttgtatggaagtgaaATTGCAag aataacccatacGGTGGTAATATATTGTTTGAttttcccatattcatagatttggagg t" /listShort="yjdJ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1225485..1226052) /Source="Nicolas_S_feature" /locus_tag="new_1278946_1279513_c" /HighExp="S8, S6, nit, S7, ferm, S2, S5, M9-tran, M/G, GM 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.987, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S443" promotor_-35 complement(1225504..1225509) /Source="Nicolas_upshift_promotors" /id="U985" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.428571428571429" /psig="0.994005994005994" /xcortree=3103 /SigmaFactorBS="aaatagacttgcgtttgagttgtatggaagtgaaATTGCAag aataacccatacGGTGGTAATATATTGTTTGAttttcccatattcatagatttggagg t" /listShort="yjdJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1225537..1225541 /Source="Nicolas_upshift_promotors" /id="U986" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.913086913086913" /psig="0.996003996003996" /xcortree=2745 /SigmaFactorBS="tcttgcaatttcacttccatacaactcaaacgcaagTCTATt tttttgtttgttttTGGCTTATAATACCTGATGAtggaaaaagagtgcgggtttatag a" /listShort="S444" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1225557..1225576 /Source="Nicolas_upshift_promotors" /id="U986" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.913086913086913" /psig="0.996003996003996" /xcortree=2745 /SigmaFactorBS="tcttgcaatttcacttccatacaactcaaacgcaagTCTATt tttttgtttgttttTGGCTTATAATACCTGATGAtggaaaaagagtgcgggtttatag a" /listShort="S444" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1225561..1226062 /Source="Nicolas_S_feature" /locus_tag="new_1279022_1279523" /HighExp="LBGstat, C30, HPh, Oxctl, dia15, Paraq, T0.30H, C90, LBGtran, LPh" /AntisenseName="ctaO" /AntisenseCor="-0.43946575370083102" /AntisenseRegPval="-13.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S444" upshifts 1225561 /Source="Nicolas_upshifts" /id="U986" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.913086913086913" /psig="0.996003996003996" /xcortree=2745 /SigmaFactorBS="tcttgcaatttcacttccatacaactcaaacgcaagTCTATt tttttgtttgttttTGGCTTATAATACCTGATGAtggaaaaagagtgcgggtttatag a" /listShort="S444" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1226053..1227042) /gene="ctaO" /locus_tag="BSU_12080" /old_locus_tag="BSU12080" /EC_number="2.5.1.-" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10675592, 15491161, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10675592, 15491161, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="minor protoheme IX farnesyltransferase 1 (heme Osynthase)" /protein_id="NP_389090.2" /db_xref="EnsemblGenomes-Gn:BSU12080" /db_xref="EnsemblGenomes-Tr:CAB13065" /db_xref="GOA:O31652" /db_xref="InterPro:IPR000537" /db_xref="InterPro:IPR006369" /db_xref="InterPro:IPR030470" /db_xref="SubtiList:BG13183" /db_xref="UniProtKB/Swiss-Prot:O31652" /translation="MQFWGRRLFLENTRDSAAISETKYIKASNRVTIYDFIKLAKPGI IISNSIAAFGGFWIAFASAEKTLTGLAFLMTMVTAMLGTAFVMASGTVYNNYFDRHMD AKMARTRSRASVTGKMPPAMILTYGSVLGIAGLAMLYSLNPLTAFLGLAAFIFYAIIY TVWVKRTSVWSTFVGSFPGAAPPLMGYCAVTGDFSMTAVLLYTIMFLWQPPHFWAIGI RRKEEYRAAGVPLLPVVKGNHVTKIKMMQYIAVLVPVTLLFPFSLGTGHISPFYFLAA LVLGGIWIKKSIKGFKTDDDVKWAKDMFVYSLIYFCLLFFIMMIDSFMMFLIR*" /label="ctaO CDS" gene complement(1226053..1227042) /gene="ctaO" /locus_tag="BSU_12080" /old_locus_tag="BSU12080" /label="ctaO gene" promotor_-10 complement(1227043..1227062) /Source="Nicolas_upshift_promotors" /id="U987" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.36963036963037" /psig="0.987012987012987" /xcortree=2978 /SigmaFactorBS="aatatcatgacaaatatgggaaataATTGTGattctgtcccc ctCTTGTTACGATAACAAAAGCatgcagttttgggggaggcgtctatttttggagaat a" /listShort="ctaO, S443, yjdJ" /listLong="yjzH" /label="promotor_-10" upshifts complement(1227046) /Source="Nicolas_upshifts" /id="U987" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.36963036963037" /psig="0.987012987012987" /xcortree=2978 /SigmaFactorBS="aatatcatgacaaatatgggaaataATTGTGattctgtcccc ctCTTGTTACGATAACAAAAGCatgcagttttgggggaggcgtctatttttggagaat a" /listShort="ctaO, S443, yjdJ" /listLong="yjzH" /label="upshifts" promotor_-35 complement(1227076..1227081) /Source="Nicolas_upshift_promotors" /id="U987" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.36963036963037" /psig="0.987012987012987" /xcortree=2978 /SigmaFactorBS="aatatcatgacaaatatgggaaataATTGTGattctgtcccc ctCTTGTTACGATAACAAAAGCatgcagttttgggggaggcgtctatttttggagaat a" /listShort="ctaO, S443, yjdJ" /listLong="yjzH" /label="promotor_-35" CDS complement(1227165..1227413) /gene="cotT" /locus_tag="BSU_12090" /old_locus_tag="BSU12090" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:1391045, 1917883, 19933362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1391045, 1917883, 19933362; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein (inner coat)" /protein_id="NP_389091.2" /db_xref="EnsemblGenomes-Gn:BSU12090" /db_xref="EnsemblGenomes-Tr:CAB13066" /db_xref="GOA:P11863" /db_xref="SubtiList:BG10495" /db_xref="UniProtKB/Swiss-Prot:P11863" /translation="MDYPLNEQSFEQITPYDERQPYYYPRPRPPFYPPYYYPRPYYPF YPFYPRPPYYYPRPRPPYYPWYGYGGGYGGGYGGGYGY*" /label="cotT CDS" gene complement(1227165..1227413) /gene="cotT" /locus_tag="BSU_12090" /old_locus_tag="BSU12090" /label="cotT gene" downshifts complement(1227175) /Source="Nicolas_upshifts" /id="D668" /incds=0 /nref=37 /ntot=82 /MaxReadThrough="5.73194" /MaxDrop="6.23577" /score="25.0951218" /energy="-8.4" /TU="U989" /idTUdmin="U990" /TUdmin=2 /isTUend="TRUE" /label="downshifts" promotor_-35 1227409..1227413 /Source="Nicolas_upshift_promotors" /id="U988" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=705 /SigmaFactorBS="gggtaatttgttcaaatgactgttcattcaaagggtaaTCCA AgaggaaaaCCTCCCTAGCTTTTTttattccttttaccatattcctgatgcttaagtt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1227422..1227436 /Source="Nicolas_upshift_promotors" /id="U988" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=705 /SigmaFactorBS="gggtaatttgttcaaatgactgttcattcaaagggtaaTCCA AgaggaaaaCCTCCCTAGCTTTTTttattccttttaccatattcctgatgcttaagtt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1227431 /Source="Nicolas_upshifts" /id="U988" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=705 /SigmaFactorBS="gggtaatttgttcaaatgactgttcattcaaagggtaaTCCA AgaggaaaaCCTCCCTAGCTTTTTttattccttttaccatattcctgatgcttaagtt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1227438..1227457) /Source="Nicolas_upshift_promotors" /id="U989" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1278 /SigmaFactorBS="ataaaaaaaaccgaatttcatgaatgtACATACACCCaactt aagcatcaGGAATATGGTAAAAGGAATAaaaaaagctagggaggttttcctcttggat t" /listShort="cotT, ctaO, S443" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1227447) /Source="Nicolas_upshifts" /id="U989" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1278 /SigmaFactorBS="ataaaaaaaaccgaatttcatgaatgtACATACACCCaactt aagcatcaGGAATATGGTAAAAGGAATAaaaaaagctagggaggttttcctcttggat t" /listShort="cotT, ctaO, S443" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1227471..1227480) /Source="Nicolas_upshift_promotors" /id="U989" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1278 /SigmaFactorBS="ataaaaaaaaccgaatttcatgaatgtACATACACCCaactt aagcatcaGGAATATGGTAAAAGGAATAaaaaaagctagggaggttttcctcttggat t" /listShort="cotT, ctaO, S443" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1227528..1227535 /Source="Nicolas_upshift_promotors" /id="U991" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.713286713286713" /psig="0.994005994005994" /xcortree=1545 /SigmaFactorBS="ttttatgatgaaattccttaaaaaggATTGACATgaacttct aaatcTCATAGTATTACAAATGTGAaataaatgttactacaatgttacaaaaacattt c" /listShort="S445, yjeA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1227542..1227561) /Source="Nicolas_upshift_promotors" /id="U990" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.433566433566434" /psig="0.684315684315684" /xcortree=2052 /SigmaFactorBS="atctatttagaaatgtttttgtaacattgTAGTAACAtttat ttcacattTGTAATACTATGAGATTTAGaagttcatgtcaatcctttttaaggaattt c" /listShort="cotT" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 1227549..1227568 /Source="Nicolas_upshift_promotors" /id="U991" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.713286713286713" /psig="0.994005994005994" /xcortree=1545 /SigmaFactorBS="ttttatgatgaaattccttaaaaaggATTGACATgaacttct aaatcTCATAGTATTACAAATGTGAaataaatgttactacaatgttacaaaaacattt c" /listShort="S445, yjeA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1227551) /Source="Nicolas_upshifts" /id="U990" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.433566433566434" /psig="0.684315684315684" /xcortree=2052 /SigmaFactorBS="atctatttagaaatgtttttgtaacattgTAGTAACAtttat ttcacattTGTAATACTATGAGATTTAGaagttcatgtcaatcctttttaaggaattt c" /listShort="cotT" /GFF_Attribute="listLong" /label="upshifts" upshifts 1227562 /Source="Nicolas_upshifts" /id="U991" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.713286713286713" /psig="0.994005994005994" /xcortree=1545 /SigmaFactorBS="ttttatgatgaaattccttaaaaaggATTGACATgaacttct aaatcTCATAGTATTACAAATGTGAaataaatgttactacaatgttacaaaaacattt c" /listShort="S445, yjeA" /GFF_Attribute="listLong" /label="upshifts" S_feature 1227563..1227666 /Source="Nicolas_S_feature" /locus_tag="new_1281024_1281127" /HighExp="Heat, T0.30H, T1.0H, ferm, Diami, dia5, T1.30H, M9-stat, T3.0H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S445" promotor_-35 complement(1227575..1227582) /Source="Nicolas_upshift_promotors" /id="U990" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.433566433566434" /psig="0.684315684315684" /xcortree=2052 /SigmaFactorBS="atctatttagaaatgtttttgtaacattgTAGTAACAtttat ttcacattTGTAATACTATGAGATTTAGaagttcatgtcaatcctttttaaggaattt c" /listShort="cotT" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1227667..1229070 /gene="pdaC" /locus_tag="BSU_12100" /old_locus_tag="BSU12100" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14679227, 17878218, 22277649" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14679227, 17878218, 22277649; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylmuramic acid deacetylase" /protein_id="NP_389092.1" /db_xref="EnsemblGenomes-Gn:BSU12100" /db_xref="EnsemblGenomes-Tr:CAB13067" /db_xref="GOA:O34798" /db_xref="InterPro:IPR002509" /db_xref="InterPro:IPR011330" /db_xref="InterPro:IPR017219" /db_xref="InterPro:IPR021729" /db_xref="InterPro:IPR025303" /db_xref="InterPro:IPR037126" /db_xref="SubtiList:BG13184" /db_xref="UniProtKB/Swiss-Prot:O34798" /translation="MLAKRIKWFHVLIAVVCVVGLIGFFHNHSLKKETVMNKVRTDSQ YGNVEIATLVNDGKTFNYAVNYPVFKNEKMDSALKRFAEKEVRQFQKETKDVDQEHTT KRNELNVDYKIVHYAKQTVAIVFNEYKYIGGAHGQTVKKTFNYDFSKQAFLSIDDIFK EDADYLHKLSLIAYHELKKNKDIAADDALLKEGTAPKKENFSRFAIKEDYIELYFDTY QVAAGYLGEQSIAIKKSLLKDILKEQYIDKAKNKNKIKEQKPKHEVISLPKEETVDPN QKVIALTFDDGPNPATTNQILDSLKKYKGHATFFVLGSRVQYYPETLIRMLKEGNEVG NHSWSHPLLTRLSVKEALKQINDTQDIIEKISGYRPTLVRPPYGGINDELRSQMKMDV ALWDVDPEDWKDRNKKTIVDRVMNQAGDGRTILIHDIYRTSADAADEIIKKLTDQGYQ LVTVSQLEEVKKQREAK*" /label="pdaC CDS" gene 1227667..1229070 /gene="pdaC" /locus_tag="BSU_12100" /old_locus_tag="BSU12100" /label="pdaC gene" downshifts 1229059 /Source="Nicolas_upshifts" /id="D669" /incds=0 /nref=173 /ntot=238 /MaxReadThrough="1.38483" /MaxDrop="6.60322" /score="39.935002" /energy="-13.8" /TU="NA" /idTUdmin="U991" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1229110..1229583) /gene="yjfA" /locus_tag="BSU_12110" /old_locus_tag="BSU12110" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389093.1" /db_xref="EnsemblGenomes-Gn:BSU12110" /db_xref="EnsemblGenomes-Tr:CAB13068" /db_xref="InterPro:IPR021224" /db_xref="SubtiList:BG13185" /db_xref="UniProtKB/Swiss-Prot:O34554" /translation="MKRLFMKASLVLFAVVFVFAVKGAPAKAETHAYDGKSPYYNDCA SSGSTKKSSNLVNASNQVIGVVELKFSSTCKTAWAKITMNNTLTSGYEANAEITRNTD GKRYNCDSAGGNGKAVAGQKSCYTPMVYDLDPRTSYAFGKYSGPNLNVWATTGSY*" /label="yjfA CDS" gene complement(1229110..1229583) /gene="yjfA" /locus_tag="BSU_12110" /old_locus_tag="BSU12110" /label="yjfA gene" downshifts complement(1229114) /Source="Nicolas_upshifts" /id="D670" /incds=0 /nref=33 /ntot=176 /MaxReadThrough="2.25434" /MaxDrop="5.38548" /score="20.5383759" /energy="-13.8" /TU="NA" /idTUdmin="U992" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1229605..1229623) /Source="Nicolas_upshift_promotors" /id="U992" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1105 /SigmaFactorBS="ctccatcctcccggccgcctttattgttcacaaaaaagcaTG CATGttttgattgttcctCCATATGATTTATTGTTTGccatattaaggaggtcataaa t" /listShort="yjfA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1229623) /Source="Nicolas_upshifts" /id="U992" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1105 /SigmaFactorBS="ctccatcctcccggccgcctttattgttcacaaaaaagcaTG CATGttttgattgttcctCCATATGATTTATTGTTTGccatattaaggaggtcataaa t" /listShort="yjfA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1229638..1229643) /Source="Nicolas_upshift_promotors" /id="U992" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1105 /SigmaFactorBS="ctccatcctcccggccgcctttattgttcacaaaaaagcaTG CATGttttgattgttcctCCATATGATTTATTGTTTGccatattaaggaggtcataaa t" /listShort="yjfA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1229708..1229875) /gene="yjfB" /locus_tag="BSU_12120" /old_locus_tag="BSU12120" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15033535" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389094.1" /db_xref="EnsemblGenomes-Gn:BSU12120" /db_xref="EnsemblGenomes-Tr:CAB13069" /db_xref="InterPro:IPR025906" /db_xref="SubtiList:BG13186" /db_xref="UniProtKB/Swiss-Prot:O34438" /translation="MDIPALSVAMHQASLAQNVNIALTKKRLDTAQQNADQTLKMIQH PTLGQTIDVKA*" /label="yjfB CDS" gene complement(1229708..1229875) /gene="yjfB" /locus_tag="BSU_12120" /old_locus_tag="BSU12120" /label="yjfB gene" downshifts complement(1229711) /Source="Nicolas_upshifts" /id="D671" /incds=0 /nref=109 /ntot=232 /MaxReadThrough="3.53249" /MaxDrop="4.93218" /score="-9.08395816" /energy="-13.9" /TU="U993" /idTUdmin="U993" /TUdmin="-576" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1229887..1229905) /Source="Nicolas_upshift_promotors" /id="U993" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2829 /SigmaFactorBS="gggtcaacaagagaaattaagccatttttcaCTGTAAAAtca tacaaacccGCCGATAGGTAAGGCATAGgaggtggaaccatggatattcctgctttat c" /listShort="yjfB, yjfA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1229896) /Source="Nicolas_upshifts" /id="U993" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2829 /SigmaFactorBS="gggtcaacaagagaaattaagccatttttcaCTGTAAAAtca tacaaacccGCCGATAGGTAAGGCATAGgaggtggaaccatggatattcctgctttat c" /listShort="yjfB, yjfA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1229918..1229925) /Source="Nicolas_upshift_promotors" /id="U993" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2829 /SigmaFactorBS="gggtcaacaagagaaattaagccatttttcaCTGTAAAAtca tacaaacccGCCGATAGGTAAGGCATAGgaggtggaaccatggatattcctgctttat c" /listShort="yjfB, yjfA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1230002..1230901 /gene="yjfC" /locus_tag="BSU_12130" /old_locus_tag="BSU12130" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389095.2" /db_xref="EnsemblGenomes-Gn:BSU12130" /db_xref="EnsemblGenomes-Tr:CAB13070" /db_xref="InterPro:IPR018728" /db_xref="SubtiList:BG13187" /db_xref="UniProtKB/Swiss-Prot:O34458" /translation="MNLVMEKTFEQYEKLFSMEEQKREDVFRYTMMRPFEKMWTAIQV PLKAKEPNGYDVIMAAKMLGYLDVRDAESGQKALQILKESHVSETAESALRQCIFFAE REQLRVNAKEIKFGLYIADPNKLQLQKGYCGFGGIPGFIHVWINPNSYNLPRIPSIIA HEFHHNVRFSYIDFHHGSVSVGDYLVIEGLAESFARELFGTERLGPWVTRFDHEDLQY SIDVINEVLDVKGFSEVSRYMFGDPIANDQGFKPAGLSAFAGYAVGYHAVQSFMNQHH ITISEATRLDAKTIISQCGLFST*" /label="yjfC CDS" gene 1230002..1230901 /gene="yjfC" /locus_tag="BSU_12130" /old_locus_tag="BSU12130" /label="yjfC gene" CDS complement(1230910..1231308) /gene="yjgA" /locus_tag="BSU_12140" /old_locus_tag="BSU12140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406" /codon_start=1 /transl_table=11 /product="conserved membrane protein" /protein_id="NP_389096.1" /db_xref="EnsemblGenomes-Gn:BSU12140" /db_xref="EnsemblGenomes-Tr:CAB13071" /db_xref="GOA:O35027" /db_xref="InterPro:IPR021257" /db_xref="SubtiList:BG13188" /db_xref="UniProtKB/Swiss-Prot:O35027" /translation="MKRNRWIYAVFTILIIGLGLGSRAFSSVLPDTLNTYLGDSLWAA MIFTGCGFLFRKLKTMITGIISLSFCFVIEFSQLYHAEWIDQIRDTSLGGLVLGYGFL WSDIEAYTIGIAACAAIELLVLGIKKRRCM*" /label="yjgA CDS" gene complement(1230910..1231308) /gene="yjgA" /locus_tag="BSU_12140" /old_locus_tag="BSU12140" /label="yjgA gene" downshifts complement(1230940) /Source="Nicolas_upshifts" /id="D672" /incds=0 /nref=2 /ntot=27 /MaxReadThrough="2.86089" /MaxDrop="2.52307" /score="23.8106216" /energy="-10.1" /TU="U994,U995" /idTUdmin="U995" /TUdmin="-243" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1231337..1231356) /Source="Nicolas_upshift_promotors" /id="U994" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=1954 /SigmaFactorBS="caaaataaacaccctacgcggctattcagccgctttttTAGT GGACaaataaaagctataTTCCTTACAATACAGGGAGAtgaagcagagacggggtatc a" /listShort="yjgA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1231356) /Source="Nicolas_upshifts" /id="U994" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=1954 /SigmaFactorBS="caaaataaacaccctacgcggctattcagccgctttttTAGT GGACaaataaaagctataTTCCTTACAATACAGGGAGAtgaagcagagacggggtatc a" /listShort="yjgA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1231371..1231378) /Source="Nicolas_upshift_promotors" /id="U994" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=1954 /SigmaFactorBS="caaaataaacaccctacgcggctattcagccgctttttTAGT GGACaaataaaagctataTTCCTTACAATACAGGGAGAtgaagcagagacggggtatc a" /listShort="yjgA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1231409..1231984) /gene="yjgB" /locus_tag="BSU_12150" /old_locus_tag="BSU12150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 1580552" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_389097.1" /db_xref="EnsemblGenomes-Gn:BSU12150" /db_xref="EnsemblGenomes-Tr:CAB13072" /db_xref="InterPro:IPR025453" /db_xref="PDB:4YGT" /db_xref="SubtiList:BG13189" /db_xref="UniProtKB/Swiss-Prot:O34960" /translation="MKKTMSAITAAAAVTSCFTGFGAASFSAPAKAAAQTNTLSENTN QSAAELVKNLYNTAYKGEMPQQAQGLTINKSTKGDVHAAFGEPERPVGGDNRFDLYHW NMGQPGYGFSYHKDMTISEIRYFGTGVERQLNLGGVTPEVLQKQLGPVNRVLTVPFTD EIDYVYDTGRYELHFVIGTDQTADHVNLKAK*" /label="yjgB CDS" gene complement(1231409..1231984) /gene="yjgB" /locus_tag="BSU_12150" /old_locus_tag="BSU12150" /label="yjgB gene" downshifts complement(1231424) /Source="Nicolas_upshifts" /id="D673" /incds=0 /nref=3 /ntot=16 /MaxReadThrough="5.38565" /MaxDrop="3.9021" /score="23.8106216" /energy="-10.1" /TU="U995" /idTUdmin="U995" /TUdmin="-727" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1232003..1232021) /Source="Nicolas_upshift_promotors" /id="U995" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=183 /SigmaFactorBS="tacaacaactcaataaaacatacaaagcgcactcacaTGTTT CGttgcaaaaacacgGGGAAACGGAATGGTAGATcaattaggagggattaacatgaaa a" /listShort="yjgB, yjgA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1232018) /Source="Nicolas_upshifts" /id="U995" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=183 /SigmaFactorBS="tacaacaactcaataaaacatacaaagcgcactcacaTGTTT CGttgcaaaaacacgGGGAAACGGAATGGTAGATcaattaggagggattaacatgaaa a" /listShort="yjgB, yjgA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1232035..1232041) /Source="Nicolas_upshift_promotors" /id="U995" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=183 /SigmaFactorBS="tacaacaactcaataaaacatacaaagcgcactcacaTGTTT CGttgcaaaaacacgGGGAAACGGAATGGTAGATcaattaggagggattaacatgaaa a" /listShort="yjgB, yjgA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1232059..1232065 /Source="Nicolas_upshift_promotors" /id="U996" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=186 /SigmaFactorBS="ccgtgtttttgcaacgaaacatgtgagtgcgctttgtaTGTT TTAttgagttgttgtaaGGGAACTGAAATAGGTAATtcggtatataaagcaagaaagg g" /listShort="yjgC, yjgD, S446, yjhA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1232080..1232098 /Source="Nicolas_upshift_promotors" /id="U996" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=186 /SigmaFactorBS="ccgtgtttttgcaacgaaacatgtgagtgcgctttgtaTGTT TTAttgagttgttgtaaGGGAACTGAAATAGGTAATtcggtatataaagcaagaaagg g" /listShort="yjgC, yjgD, S446, yjhA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1232081 /Source="Nicolas_upshifts" /id="U996" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=186 /SigmaFactorBS="ccgtgtttttgcaacgaaacatgtgagtgcgctttgtaTGTT TTAttgagttgttgtaaGGGAACTGAAATAGGTAATtcggtatataaagcaagaaagg g" /listShort="yjgC, yjgD, S446, yjhA" /GFF_Attribute="listLong" /label="upshifts" CDS 1232130..1235087 /gene="yjgC" /locus_tag="BSU_12160" /old_locus_tag="BSU12160" /EC_number="1.2.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative molybdoenzyme; putative formate dehydrogenase" /protein_id="NP_389098.1" /db_xref="EnsemblGenomes-Gn:BSU12160" /db_xref="EnsemblGenomes-Tr:CAB13073" /db_xref="GOA:O34720" /db_xref="InterPro:IPR001041" /db_xref="InterPro:IPR006478" /db_xref="InterPro:IPR006656" /db_xref="InterPro:IPR006657" /db_xref="InterPro:IPR006963" /db_xref="InterPro:IPR009010" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR017900" /db_xref="InterPro:IPR019574" /db_xref="InterPro:IPR036010" /db_xref="SubtiList:BG13190" /db_xref="UniProtKB/Swiss-Prot:O34720" /translation="MAGKKTITINGVEMEASEEQTVLQLLNNSSIEVPQVCYHPSLGP IETCDTCIVSINGELKRSCSAELKDGDVIDTLSPDVKKAQVIGMDKILYNHELYCTVC DYNNGGCEIHNTVKEMKINHQSIPFDHKPYHKDESHPFYRYDPDQCILCGRCVEACQD VQVTETLTIDWERKRPRVIWDNDVPINESSCVSCGHCSTVCPCNAMMEKGMEGEAGYL TGINNETLRPMIEITKGVETGYGSILAISDMESAMRDERIKKTKTVCTYCGVGCSFDV WTKGRDILKVEPQEEAPANGISTCVKGKFGWDFVNSEERLTKPLIREGDHFREAEWEE ALLLIASKFTELKEAFGPDSLAFITSSKCTNEESYLMQKLARGVIGTNNVDNCSRYCQ SPATAGLFRTVGYGGDSGSITDIAQADLVLIIGSNTSESHPVLSTRIKRAHKLRGQKV IVADIRKHEMAERSDLFVQPRAGSDIVWLNAIAKYLIENGKADERFLRERVNGRDEYV KSLAPYTLEYAEEKTGIDQETLIQMAEMIGQADSVCALWAMGVTQHIGGSDTSTAISN LLLVTGNYGKPGAGSYPLRGHNNVQGASDFGSMPDRLPGYEKVTDEQVRQKYERVWGV PLPKEPGMTNHEMIEKIHSGQLKAMYVKGEEMGLVDSNINHVHAAYEKLDFFVVQDIF LSRTAEFADVVLPASPSLEKEGTFTNTERRIQRLYQVFEPLGESKPDWQIIMEVANKL GAGWLYEHPADIMEEAAKLSPIYAGVTYERLEGYNSLQWPVNADGKDSPLLFTERFPF PDGKAILYPVQWTEPKEFGEEYDIHVNNGRLLEHFHEGNLTYKSKGISEKTPEVFLEI SPELAAERGIQDGTLVRLTSPFGNVKVKCLITDRVKGKEVYLPMNDSGEAAINLLTGS HADKDTDTPAYKETSAKMEILKHDGISPLPKINHRNGNPQPQIGVQVHKKWARKDYIF PGDAVKRGMGHNG*" /label="yjgC CDS" gene 1232130..1235087 /gene="yjgC" /locus_tag="BSU_12160" /old_locus_tag="BSU12160" /label="yjgC gene" CDS 1235080..1235640 /gene="yjgD" /locus_tag="BSU_12170" /old_locus_tag="BSU12170" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389099.1" /db_xref="EnsemblGenomes-Gn:BSU12170" /db_xref="EnsemblGenomes-Tr:CAB13074" /db_xref="InterPro:IPR012440" /db_xref="SubtiList:BG13191" /db_xref="UniProtKB/Swiss-Prot:O34681" /translation="MAKAIKRIQKIEVTEEDQRKRDLREIEDALIDHKEAILETLHML GHMNERGVLPLLRGLFGQGDKVLDILVKKADTEETANTLKNLLLLFGTLGMLDVKQLE PLILKVNAGVASAVEQKNSEEKTGYFDIIRSLKDPEINKSITLLFSFLKGMGQDTKEL ERTTQPPEHQKHHQEPREKRGMNKRD*" /label="yjgD CDS" gene 1235080..1235640 /gene="yjgD" /locus_tag="BSU_12170" /old_locus_tag="BSU12170" /label="yjgD gene" downshifts 1235633 /Source="Nicolas_upshifts" /id="D674" /incds=0 /nref=18 /ntot=84 /MaxReadThrough="5.25706" /MaxDrop="6.46184" /score="20.7921843" /energy="-15" /TU="U996" /idTUdmin="U996" /TUdmin="-819" /isTUend="FALSE" /label="downshifts" S_feature 1235678..1235796 /Source="Nicolas_S_feature" /locus_tag="new_1289139_1289257" /HighExp="Etha, Salt, Heat, S8, M9-stat, S7, LPhT, G135, C30, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S446" promotor_-35 1235774..1235777 /Source="Nicolas_upshift_promotors" /id="U997" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.998001998001998" /xcortree=2980 /SigmaFactorBS="tgatgaatgagatagaaataatcgttactttcttacCTGTta agaaaagggaaaaTCTGATTATAATAGAAATCGattactttagatgggggaacaatca t" /listShort="yjhA, yjhB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1235793..1235812 /Source="Nicolas_upshift_promotors" /id="U997" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.998001998001998" /xcortree=2980 /SigmaFactorBS="tgatgaatgagatagaaataatcgttactttcttacCTGTta agaaaagggaaaaTCTGATTATAATAGAAATCGattactttagatgggggaacaatca t" /listShort="yjhA, yjhB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1235798 /Source="Nicolas_upshifts" /id="U997" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.998001998001998" /xcortree=2980 /SigmaFactorBS="tgatgaatgagatagaaataatcgttactttcttacCTGTta agaaaagggaaaaTCTGATTATAATAGAAATCGattactttagatgggggaacaatca t" /listShort="yjhA, yjhB" /GFF_Attribute="listLong" /label="upshifts" CDS 1235837..1236478 /gene="yjhA" /locus_tag="BSU_12180" /old_locus_tag="BSU12180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_389100.1" /db_xref="EnsemblGenomes-Gn:BSU12180" /db_xref="EnsemblGenomes-Tr:CAB13075" /db_xref="GOA:O34725" /db_xref="InterPro:IPR029050" /db_xref="InterPro:IPR029051" /db_xref="PDB:3CFU" /db_xref="SubtiList:BG13192" /db_xref="UniProtKB/Swiss-Prot:O34725" /translation="MKKVLLLLFVLTIGLALSACSQSSDASEKEKPKEKKSQEELEKE LDKELKKGGEPKTKKDDQIHKIGETFKAGHTNFTVNKVDRVQKGEYMNVGGAVNEETK TIKDDEERLIIEVTMENIGEDSISYNFIGFDLRDKNDQSVRPVFSIEEKGRILMGGTL VSGKKVTGVLSYVIPKGEQKHYTLVYNPFLADTNSSNTEERVKDDIDYLVKLD*" /label="yjhA CDS" gene 1235837..1236478 /gene="yjhA" /locus_tag="BSU_12180" /old_locus_tag="BSU12180" /label="yjhA gene" downshifts complement(1235846) /Source="Nicolas_upshifts" /id="D675" /incds=0 /nref=7 /ntot=57 /MaxReadThrough="2.5769" /MaxDrop="3.81596" /score="-9.34186213" /energy="-3" /TU="NA" /idTUdmin="U998" /TUdmin=1386 /isTUend="FALSE" /label="downshifts" downshifts 1236451 /Source="Nicolas_upshifts" /id="D676" /incds=0 /nref=24 /ntot=186 /MaxReadThrough="4.29897" /MaxDrop="3.4683" /score="19.6571267" /energy="-17" /TU="U997" /idTUdmin="U996" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS 1236557..1237183 /gene="yjhB" /locus_tag="BSU_12190" /old_locus_tag="BSU12190" /EC_number="3.6.1.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12483591, 16513759; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ADP-ribose pyrophosphatase" /protein_id="NP_389101.2" /db_xref="EnsemblGenomes-Gn:BSU12190" /db_xref="EnsemblGenomes-Tr:CAB13076" /db_xref="GOA:C0SPC3" /db_xref="InterPro:IPR000086" /db_xref="InterPro:IPR015797" /db_xref="SubtiList:BG13193" /db_xref="UniProtKB/Swiss-Prot:C0SPC3" /translation="MIKVQTKWLERAQRIRAIAQAGLAFSKDVYDRERYEELMKLSAE MMADYSEKDIEVITDLWQGEKGYPTPKADVRGAVFRENQILLVREKHDELWSLPGGFC EIGLSPAENVVKEIKEESGYDTEPSRLLAVLDSHKHSHPPQPYHYYKIFIACSMTDGQ GETGIETNHAAFFPEDRLPPLSPKRNTPSQLSMLFDFLRHPDKKTIFD*" /label="yjhB CDS" gene 1236557..1237183 /gene="yjhB" /locus_tag="BSU_12190" /old_locus_tag="BSU12190" /label="yjhB gene" downshifts 1237185 /Source="Nicolas_upshifts" /id="D677" /incds=0 /nref=97 /ntot=202 /MaxReadThrough="0.597580000000001" /MaxDrop="6.62023" /score="12.2319602" /energy="-7" /TU="NA" /idTUdmin="U997" /TUdmin=7 /isTUend="TRUE" /label="downshifts" downshifts complement(1237188) /Source="Nicolas_upshifts" /id="D678" /incds=0 /nref=1 /ntot=9 /MaxReadThrough="0.18907" /MaxDrop="3.31161" /score="10.5815896" /energy="-7" /TU="NA" /idTUdmin="U998" /TUdmin=44 /isTUend="FALSE" /label="downshifts" CDS complement(1237214..1237492) /gene="yjiA" /locus_tag="BSU_12200" /old_locus_tag="BSU12200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 14563871" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_389102.1" /db_xref="EnsemblGenomes-Gn:BSU12200" /db_xref="EnsemblGenomes-Tr:CAB13077" /db_xref="SubtiList:BG13194" /db_xref="UniProtKB/Swiss-Prot:O34679" /translation="MAAQTDYKKQVVGILLSLAFVLFVFSFSERHEKPLVEGKKQENW HTVVDKASVKIYGSRLVEENKLKQKLGHKQADSILTLLKLANEKHITL*" /label="yjiA CDS" gene complement(1237214..1237492) /gene="yjiA" /locus_tag="BSU_12200" /old_locus_tag="BSU12200" /label="yjiA gene" downshifts complement(1237232) /Source="Nicolas_upshifts" /id="D679" /incds=0 /nref=162 /ntot=247 /MaxReadThrough="1.96302" /MaxDrop="5.98058" /score="10.5815896" /energy="-7" /TU="NA" /idTUdmin="U998" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1237521..1237532) /Source="Nicolas_upshift_promotors" /id="U998" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.632367632367632" /psig="0.972027972027972" /xcortree=575 /SigmaFactorBS="gtctctgttttcaaccaaatgcactaactccaaaaatgactt tcccattatgtaaaataaTTTGGTTcTATGATTAAATAgaaggtaaaaggtgaaggag a" /listShort="yjiA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1237534..1237540) /Source="Nicolas_upshift_promotors" /id="U998" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.632367632367632" /psig="0.972027972027972" /xcortree=575 /SigmaFactorBS="gtctctgttttcaaccaaatgcactaactccaaaaatgactt tcccattatgtaaaataaTTTGGTTcTATGATTAAATAgaaggtaaaaggtgaaggag a" /listShort="yjiA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1237540) /Source="Nicolas_upshifts" /id="U998" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.632367632367632" /psig="0.972027972027972" /xcortree=575 /SigmaFactorBS="gtctctgttttcaaccaaatgcactaactccaaaaatgactt tcccattatgtaaaataaTTTGGTTcTATGATTAAATAgaaggtaaaaggtgaaggag a" /listShort="yjiA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1237542..1237958) /Source="Nicolas_S_feature" /locus_tag="new_1291003_1291419_c" /HighExp="S6, S7, S8, S5, BT, C30, Pyr, G/S, C90, B36" /AntisenseName="yjiB" /AntisenseCor="-0.25565388711625397" /AntisenseRegPval="-4.7" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S447" upshifts 1237710 /Source="Nicolas_upshifts" /id="U999" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.766233766233766" /psig=1 /xcortree=3183 /SigmaFactorBS="tatgcctaaggtcacgttgtgagccaaaacagcagtgcagaa tagaaaaaaattgaaagatTATGGTAAGATGAACGAAATtcgagggggaatatatgat g" /listShort="S448, yjiB, yjiC" /GFF_Attribute="listLong" /label="upshifts" misc_feature 1237711..1237730 /Source="Nicolas_upshift_promotors" /id="U999" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.766233766233766" /psig=1 /xcortree=3183 /SigmaFactorBS="tatgcctaaggtcacgttgtgagccaaaacagcagtgcagaa tagaaaaaaattgaaagatTATGGTAAGATGAACGAAATtcgagggggaatatatgat g" /listShort="S448, yjiB, yjiC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1237728..1237882 /Source="Nicolas_S_feature" /locus_tag="new_1291189_1291343" /HighExp="BC, T5.0H, T4.0H, C90, Sw, T3.30H, Lbstat, Diami, dia5, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.995811" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S448" CDS 1237883..1239073 /gene="cypE" /locus_tag="BSU_12210" /old_locus_tag="BSU12210" /EC_number="1.14.-.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:25587700" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25587700; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome P450 CYP109B1, monooxygenase" /protein_id="NP_389103.1" /db_xref="EnsemblGenomes-Gn:BSU12210" /db_xref="EnsemblGenomes-Tr:CAB13078" /db_xref="GOA:O34374" /db_xref="InterPro:IPR001128" /db_xref="InterPro:IPR002397" /db_xref="InterPro:IPR017972" /db_xref="InterPro:IPR036396" /db_xref="PDB:4RM4" /db_xref="SubtiList:BG13195" /db_xref="UniProtKB/Swiss-Prot:O34374" /translation="MNVLNRRQALQRALLNGKNKQDAYHPFPWYESMRKDAPVSFDEE NQVWSVFLYDDVKKVVGDKELFSSCMPQQTSSIGNSIINMDPPKHTKIRSVVNKAFTP RVMKQWEPRIQEITDELIQKFQGRSEFDLVHDFSYPLPVIVISELLGVPSAHMEQFKA WSDLLVSTPKDKSEEAEKAFLEERDKCEEELAAFFAGIIEEKRNKPEQDIISILVEAE ETGEKLSGEELIPFCTLLLVAGNETTTNLISNAMYSILETPGVYEELRSHPELMPQAV EEALRFRAPAPVLRRIAKRDTEIGGHLIKEGDMVLAFVASANRDEAKFDRPHMFDIRR HPNPHIAFGHGIHFCLGAPLARLEANIALTSLISAFPHMECVSITPIENSVIYGLKSF RVKM*" /label="cypE CDS" gene 1237883..1239073 /gene="cypE" /locus_tag="BSU_12210" /old_locus_tag="BSU12210" /label="cypE gene" promotor_-10 complement(1237956..1237975) /Source="Nicolas_upshift_promotors" /id="U1000" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1374 /SigmaFactorBS="ggttttcttcatcaaaggaaACAGGCGCATcctttctcatcg aTTCATACCATGGAAACGGATgatacgcatcctgtttgtttttcccattgagcagcgc t" /listShort="S447, yjiA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1237958) /Source="Nicolas_upshifts" /id="U1000" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1374 /SigmaFactorBS="ggttttcttcatcaaaggaaACAGGCGCATcctttctcatcg aTTCATACCATGGAAACGGATgatacgcatcctgtttgtttttcccattgagcagcgc t" /listShort="S447, yjiA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1237989..1237998) /Source="Nicolas_upshift_promotors" /id="U1000" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1374 /SigmaFactorBS="ggttttcttcatcaaaggaaACAGGCGCATcctttctcatcg aTTCATACCATGGAAACGGATgatacgcatcctgtttgtttttcccattgagcagcgc t" /listShort="S447, yjiA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1239096..1240274 /gene="ppuG" /locus_tag="BSU_12220" /old_locus_tag="BSU12220" /EC_number="2.4.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 24893262, 27444326; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="polyphenols TDP-rhamnosyltransferase, promiscuous" /protein_id="NP_389104.1" /db_xref="EnsemblGenomes-Gn:BSU12220" /db_xref="EnsemblGenomes-Tr:CAB13079" /db_xref="GOA:O34539" /db_xref="InterPro:IPR002213" /db_xref="InterPro:IPR006326" /db_xref="InterPro:IPR007235" /db_xref="SubtiList:BG13196" /db_xref="UniProtKB/Swiss-Prot:O34539" /translation="MKKYHISMINIPAYGHVNPTLALVEKLCEKGHRVTYATTEEFAP AVQQAGGEALIYHTSLNIDPKQIREMMEKNDAPLSLLKESLSILPQLEELYKDDQPDL IIYDFVALAGKLFAEKLNVPVIKLCSSYAQNESFQLGNEDMLKKIREAEAEFKAYLEQ EKLPAVSFEQLAVPEALNIVFMPKSFQIQHETFDDRFCFVGPSLGERKEKESLLIDKD DRPLMLISLGTAFNAWPEFYKMCIKAFRDSSWQVIMSVGKTIDPESLEDIPANFTIRQ SVPQLEVLEKADLFISHGGMNSTMEAMNAGVPLVVIPQMYEQELTANRVDELGLGVYL PKEEVTVSSLQEAVQAVSSDQELLSRVKNMQKDVKEAGGAERAAAEIEAFMKKSAVPQ *" /label="ppuG CDS" gene 1239096..1240274 /gene="ppuG" /locus_tag="BSU_12220" /old_locus_tag="BSU12220" /label="ppuG gene" CDS complement(1240315..1240503) /gene="yjzI" /locus_tag="BSU_12229" /old_locus_tag="BSU12229" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences" /codon_start=1 /transl_table=11 /product="putative phage protein" /protein_id="YP_003097710.1" /db_xref="EnsemblGenomes-Gn:BSU12229" /db_xref="EnsemblGenomes-Tr:CAX52600" /db_xref="UniProtKB/Swiss-Prot:C0H3Z3" /translation="METKKEEYETKGYDTSIVYEFNEYPDARSGRCDNCDYTLFKSSV KGGKFLRECRRCGMKKNI*" /label="yjzI CDS" gene complement(1240315..1240503) /gene="yjzI" /locus_tag="BSU_12229" /old_locus_tag="BSU12229" /label="yjzI gene" downshifts complement(1240331) /Source="Nicolas_upshifts" /id="D680" /incds=0 /nref=94 /ntot=231 /MaxReadThrough="-0.1433" /MaxDrop="5.1712" /score="13.0160925" /energy="-9.5" /TU="NA" /idTUdmin="U1001" /TUdmin=3 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1240529..1240548) /Source="Nicolas_upshift_promotors" /id="U1001" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.34965034965035" /psig="0.993006993006993" /xcortree=2410 /SigmaFactorBS="agataaacccaacctcctaaaatcCATTGAAtacgccggaag ctTGCTGTAAGATAAACAGCAGacacgtcttgtaacggaggatcgacatggaaaccaa a" /listShort="yjzI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1240532) /Source="Nicolas_upshifts" /id="U1001" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.34965034965035" /psig="0.993006993006993" /xcortree=2410 /SigmaFactorBS="agataaacccaacctcctaaaatcCATTGAAtacgccggaag ctTGCTGTAAGATAAACAGCAGacacgtcttgtaacggaggatcgacatggaaaccaa a" /listShort="yjzI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1240562..1240568) /Source="Nicolas_upshift_promotors" /id="U1001" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.34965034965035" /psig="0.993006993006993" /xcortree=2410 /SigmaFactorBS="agataaacccaacctcctaaaatcCATTGAAtacgccggaag ctTGCTGTAAGATAAACAGCAGacacgtcttgtaacggaggatcgacatggaaaccaa a" /listShort="yjzI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1240590..1240597 /Source="Nicolas_upshift_promotors" /id="U1002" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.356643356643357" /psig="0.982017982017982" /xcortree=2379 /SigmaFactorBS="tcaatggattttaggaggttgggtttaTCTTGATTtctccct tggtttgCGCCAAAATAGCTTTATTAAgcttatatacataaaaagcctatgcaaagag g" /listShort="yjjA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1240612..1240631 /Source="Nicolas_upshift_promotors" /id="U1002" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.356643356643357" /psig="0.982017982017982" /xcortree=2379 /SigmaFactorBS="tcaatggattttaggaggttgggtttaTCTTGATTtctccct tggtttgCGCCAAAATAGCTTTATTAAgcttatatacataaaaagcctatgcaaagag g" /listShort="yjjA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1240623 /Source="Nicolas_upshifts" /id="U1002" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.356643356643357" /psig="0.982017982017982" /xcortree=2379 /SigmaFactorBS="tcaatggattttaggaggttgggtttaTCTTGATTtctccct tggtttgCGCCAAAATAGCTTTATTAAgcttatatacataaaaagcctatgcaaagag g" /listShort="yjjA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1240638..1240657) /Source="Nicolas_upshift_promotors" /id="U1003" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.868131868131868" /psig="0.868131868131868" /xcortree=1376 /SigmaFactorBS="cgttttccaagtaacccttttccCATACCCGtttcctctcct cttTGCATAGGCTTTTTATGTATataagcttaataaagctattttggcgcaaaccaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1240642) /Source="Nicolas_upshifts" /id="U1003" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.868131868131868" /psig="0.868131868131868" /xcortree=1376 /SigmaFactorBS="cgttttccaagtaacccttttccCATACCCGtttcctctcct cttTGCATAGGCTTTTTATGTATataagcttaataaagctattttggcgcaaaccaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1240672..1240679) /Source="Nicolas_upshift_promotors" /id="U1003" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.868131868131868" /psig="0.868131868131868" /xcortree=1376 /SigmaFactorBS="cgttttccaagtaacccttttccCATACCCGtttcctctcct cttTGCATAGGCTTTTTATGTATataagcttaataaagctattttggcgcaaaccaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1240677..1241489 /gene="yjjA" /locus_tag="BSU_12230" /old_locus_tag="BSU12230" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_389105.1" /db_xref="EnsemblGenomes-Gn:BSU12230" /db_xref="EnsemblGenomes-Tr:CAB13080" /db_xref="GOA:O34394" /db_xref="InterPro:IPR003754" /db_xref="InterPro:IPR036108" /db_xref="SubtiList:BG13197" /db_xref="UniProtKB/Swiss-Prot:O34394" /translation="MGKGLLGKRVAIGGSRKTEEISTIIEKQGGIPVIRPLQGTVYLA EKQVEPDLRTFAEEKADWVIFTTGIGLETLVDMAEKIGLKDEFLQAIRQAKAACRGYK TLSALKKLGITPEASDEDGTTRGLIRSLEPHDFSGKTVMVQLHGEKAPALMAFLEEKG ASVLPILPYQHIPPEEETVERLCRELMNDEVDAVCFTTAIQVRSLFDFAKGRGYINEV KKVFEERAIAAAVGKVTAEALREEGITRLLAPEIERMGAMIVELAKYYEEKE*" /label="yjjA CDS" gene 1240677..1241489 /gene="yjjA" /locus_tag="BSU_12230" /old_locus_tag="BSU12230" /label="yjjA gene" downshifts 1241468 /Source="Nicolas_upshifts" /id="D681" /incds=0 /nref=196 /ntot=254 /MaxReadThrough="3.61369" /MaxDrop="5.73094" /score="10.6328997" /energy="-14.5" /TU="U1002" /idTUdmin="U1002" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(1241535..1242287) /gene="yjkA" /locus_tag="BSU_12240" /old_locus_tag="BSU12240" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (permease)" /protein_id="NP_389106.1" /db_xref="EnsemblGenomes-Gn:BSU12240" /db_xref="EnsemblGenomes-Tr:CAB13081" /db_xref="GOA:O34684" /db_xref="InterPro:IPR005226" /db_xref="SubtiList:BG13198" /db_xref="UniProtKB/Swiss-Prot:O34684" /translation="MDYLSLSLTMIFVLIALFLSKSFKAGVEKDMIIATIRAAVQLLI IGYVLSLIFRGDHPVFILLMVLLMLAVAAQNVIKRKKNTIGSFWRVFAALAIVEIVTQ GILLSLHIIPLTARYVIPISGMVIGNSMVLSSLFLNRLNSEVGVRKEEIQLILSLGGT PKQSIQRILTSAMKMSMIPTLESQKTLGLVQLPGMMTGQILAGADPIQAVRFQLLIVF TTMASAALTCVILSVLTYPSLFTVHQQLKQNE*" /label="yjkA CDS" gene complement(1241535..1242287) /gene="yjkA" /locus_tag="BSU_12240" /old_locus_tag="BSU12240" /label="yjkA gene" downshifts complement(1241544) /Source="Nicolas_upshifts" /id="D682" /incds=0 /nref=5 /ntot=153 /MaxReadThrough="0.924970000000001" /MaxDrop="3.5673" /score="13.1058081" /energy="-12.8" /TU="NA" /idTUdmin="U1001" /TUdmin="-1210" /isTUend="FALSE" /label="downshifts" CDS complement(1242287..1243039) /gene="yjkB" /locus_tag="BSU_12250" /old_locus_tag="BSU12250" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_389107.1" /db_xref="EnsemblGenomes-Gn:BSU12250" /db_xref="EnsemblGenomes-Tr:CAB13082" /db_xref="GOA:O34756" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005670" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13199" /db_xref="UniProtKB/Swiss-Prot:O34756" /translation="MEANDQTQNIPAISFRSVRKSYKQDGQTYDVLQDVTGDIQQGAI VAVLGPSGSGKSTLLSMCNLMRTPDSGEVNIYGKEVREWNVNELRRTAALAFQSAPVL DGTVRDNLSLVQRLHQSQLYSPEKLASLAGLPPELLDRSARDLSGGQRQRLSLARTLS NPSSILLLDEITSALDPVSALEIEELIKRQHQEKKWTVMWVTHNMEQAKRIADTIWFM ADGRLLEIAETDTFFSAPQHEAAKEFLKGGTR*" /label="yjkB CDS" gene complement(1242287..1243039) /gene="yjkB" /locus_tag="BSU_12250" /old_locus_tag="BSU12250" /label="yjkB gene" CDS complement(1243159..1244133) /gene="yjlA" /locus_tag="BSU_12260" /old_locus_tag="BSU12260" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14627822, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_389108.1" /db_xref="EnsemblGenomes-Gn:BSU12260" /db_xref="EnsemblGenomes-Tr:CAB13083" /db_xref="GOA:O34428" /db_xref="InterPro:IPR032713" /db_xref="SubtiList:BG13200" /db_xref="UniProtKB/Swiss-Prot:O34428" /translation="MKAIVIGILASLFFAVTFILNRAMELSGGSWLWSSSLRFIFMVP FLCLIVIMRGTFTPLLLEMRKKPFYWIKWSFVGFVLFYAPITFAAAYGPGWLIAGTWQ ITIVAGVLLSPLFYVKQDMPGGPQLIRQKIPLVSLGTSVIILIGAALIQLQHAESLSG RMLLFSVLPVVIAAFAYPLGNRRMLEEYGGRLDTFQRVLGMTLASLPFWLILAAYGWW SDGLPTASQTVQSFIVAVSSGIIATVLFFWATDMVRDNPQKLAAVEATQSGEVIFALL GEIVLLSGVFPSLLSFAGLFIIIAGMMLHTFASQPRKPKKKAQSNLTA*" /label="yjlA CDS" gene complement(1243159..1244133) /gene="yjlA" /locus_tag="BSU_12260" /old_locus_tag="BSU12260" /label="yjlA gene" downshifts complement(1243194) /Source="Nicolas_upshifts" /id="D683" /incds=0 /nref=1 /ntot=95 /MaxReadThrough="1.84381" /MaxDrop="2.54799" /score="4.80318278" /energy="-14.5" /TU="NA" /idTUdmin="U1004" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1244154..1244173) /Source="Nicolas_upshift_promotors" /id="U1004" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.451548451548452" /psig="0.997002997002997" /xcortree=2386 /SigmaFactorBS="tccacatatagcggttcgccaaacatgatgtttttctcatga ttcCATTGATCtgcatgataccgaaTAGTATAGTATAAAAAAATAatgccagaatgag g" /listShort="yjlA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1244180) /Source="Nicolas_upshifts" /id="U1004" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.451548451548452" /psig="0.997002997002997" /xcortree=2386 /SigmaFactorBS="tccacatatagcggttcgccaaacatgatgtttttctcatga ttcCATTGATCtgcatgataccgaaTAGTATAGTATAAAAAAATAatgccagaatgag g" /listShort="yjlA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1244182..1246688) /Source="Nicolas_S_feature" /locus_tag="new_1297643_1300149_c" /HighExp="Lbstat, S2, M0t90, nit, BT, M40t90, ferm, BC, C30, Gly" /AntisenseName="ndh" /AntisenseCor="-0.74506751931257098" /AntisenseRegPval="-48.1" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S449" promotor_-35 complement(1244188..1244195) /Source="Nicolas_upshift_promotors" /id="U1004" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.451548451548452" /psig="0.997002997002997" /xcortree=2386 /SigmaFactorBS="tccacatatagcggttcgccaaacatgatgtttttctcatga ttcCATTGATCtgcatgataccgaaTAGTATAGTATAAAAAAATAatgccagaatgag g" /listShort="yjlA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1244216..1244222 /Source="Nicolas_upshift_promotors" /id="U1005" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=269 /SigmaFactorBS="atcatgcagatcaatggaatcatgagaaaaacatcaTGTTTG GcgaaccgctatatgTGGAAGACAAAAAAGGGAGgtgaaattgatggaaagagagaca c" /listShort="yjlB, S450, S451, rex, ndh" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1244237..1244255 /Source="Nicolas_upshift_promotors" /id="U1005" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=269 /SigmaFactorBS="atcatgcagatcaatggaatcatgagaaaaacatcaTGTTTG GcgaaccgctatatgTGGAAGACAAAAAAGGGAGgtgaaattgatggaaagagagaca c" /listShort="yjlB, S450, S451, rex, ndh" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1244240 /Source="Nicolas_upshifts" /id="U1005" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=269 /SigmaFactorBS="atcatgcagatcaatggaatcatgagaaaaacatcaTGTTTG GcgaaccgctatatgTGGAAGACAAAAAAGGGAGgtgaaattgatggaaagagagaca c" /listShort="yjlB, S450, S451, rex, ndh" /GFF_Attribute="listLong" /label="upshifts" CDS 1244265..1244762 /gene="yjlB" /locus_tag="BSU_12270" /old_locus_tag="BSU12270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 10704478" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; cupin family" /protein_id="NP_389109.1" /db_xref="EnsemblGenomes-Gn:BSU12270" /db_xref="EnsemblGenomes-Tr:CAB13084" /db_xref="GOA:O34612" /db_xref="InterPro:IPR006045" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014500" /db_xref="InterPro:IPR014710" /db_xref="SubtiList:BG13201" /db_xref="UniProtKB/Swiss-Prot:O34612" /translation="MERETQTYFFPDDGRIPNHPDFPLVVYQNALKDTGLAERIVTRH GWSNSWSGSVFPYHHYHSNTHEVLIALRREAVIQFGGEKGAAIPFKSGDAVVIPAGVG HKKLSSSPDFTVLGAYPGGVQYDMKTGKPNEREEAVKQIKQAALPANDPITGKREPLL EIWVK*" /label="yjlB CDS" gene 1244265..1244762 /gene="yjlB" /locus_tag="BSU_12270" /old_locus_tag="BSU12270" /label="yjlB gene" S_feature 1244763..1244876 /Source="Nicolas_S_feature" /locus_tag="new_1298224_1298337" /HighExp="Etha, M9-stat, B60, Salt, Gly, LPhT, Heat, Sw, HiTm, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S450" promotor_-35 1244856..1244860 /Source="Nicolas_upshift_promotors" /id="U1006" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.618381618381618" /psig=1 /xcortree=2641 /SigmaFactorBS="agctccatataaattaatttcataatcgaagcaattcaCGTT CaaattttgttcaaaaAGTGTTATCATATAGAAGGTaatcgaattggagttttttgtg t" /listShort="S451, rex, ndh" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1244876..1244895 /Source="Nicolas_upshift_promotors" /id="U1006" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.618381618381618" /psig=1 /xcortree=2641 /SigmaFactorBS="agctccatataaattaatttcataatcgaagcaattcaCGTT CaaattttgttcaaaaAGTGTTATCATATAGAAGGTaatcgaattggagttttttgtg t" /listShort="S451, rex, ndh" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1244878..1245150 /Source="Nicolas_S_feature" /locus_tag="new_1298339_1298611" /HighExp="LBGtran, dia5, Lbexp, LBGexp, dia0, HPh, aero, LPh, BMM, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S451" upshifts 1244878 /Source="Nicolas_upshifts" /id="U1006" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.618381618381618" /psig=1 /xcortree=2641 /SigmaFactorBS="agctccatataaattaatttcataatcgaagcaattcaCGTT CaaattttgttcaaaaAGTGTTATCATATAGAAGGTaatcgaattggagttttttgtg t" /listShort="S451, rex, ndh" /GFF_Attribute="listLong" /label="upshifts" CDS 1245151..1245573 /gene="yjlC" /locus_tag="BSU_12280" /old_locus_tag="BSU12280" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16513748, 17015645, 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389110.1" /db_xref="EnsemblGenomes-Gn:BSU12280" /db_xref="EnsemblGenomes-Tr:CAB13085" /db_xref="InterPro:IPR012440" /db_xref="SubtiList:BG13202" /db_xref="UniProtKB/Swiss-Prot:O34633" /translation="MPETIDQTNASVSQSQQDLIDQLLKPEVQESLTVLVDQLPKLTE LVNILTKSYDFAQSVATDEVLKSDTVGAITEILEPVKETAKEVAATAIEAKDRAEASN ETIGLFGLLRMLKDPQAQKLFRFANSYLEVMNERENQK*" /label="yjlC CDS" gene 1245151..1245573 /gene="yjlC" /locus_tag="BSU_12280" /old_locus_tag="BSU12280" /label="yjlC gene" CDS 1245613..1246791 /gene="ndh" /locus_tag="BSU_12290" /old_locus_tag="BSU12290" /EC_number="1.6.99.-" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:6816592, 16513748, 17015645, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6816592, 16513748, 17015645, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADH dehydrogenase" /protein_id="NP_389111.1" /db_xref="EnsemblGenomes-Gn:BSU12290" /db_xref="EnsemblGenomes-Tr:CAB13086" /db_xref="GOA:P80861" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG13203" /db_xref="UniProtKB/Swiss-Prot:P80861" /translation="MSKHIVILGAGYGGVLSALTVRKHYTKEQARVTVVNKYPTHQII TELHRLAAGNVSEKAVAMPLEKLFKGKDIDLKIAEVSSFSVDKKEVALADGSTLTYDA LVVGLGSVTAYFGIPGLEENSMVLKSAADANKVFQHVEDRVREYSKTKNEADATILIG GGGLTGVELVGELADIMPNLAKKYGVDHKEIKLKLVEAGPKILPVLPDDLIERATASL EKRGVEFLTGLPVTNVEGNVIDLKDGSKVVANTFVWTGGVQGNPLVGESGLEVNRGRA TVNDFLQSTSHEDVFVAGDSAVYFGPDGRPYPPTAQIAWQMGELIGYNLFAYLEGKTL ETFKPVNSGTLASLGRKDAVAIIGANSTPLKGLPASLMKEASNVRYLTHIKGLFSLAY *" /label="ndh CDS" gene 1245613..1246791 /gene="ndh" /locus_tag="BSU_12290" /old_locus_tag="BSU12290" /label="ndh gene" promotor_no_box 1246622..1246722 /Source="Nicolas_upshift_promotors" /id="U1007" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.59040959040959" /psig="0.015984015984016" /xcortree=1732 /SigmaFactorBS="tcaagccagtaaactctggtacacttgcaagccttggacgca aagacgcggttgccatcattggtgctaattctacaccgcttaaaggtcttcctgcttc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-10 complement(1246680..1246698) /Source="Nicolas_upshift_promotors" /id="U1008" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=506 /SigmaFactorBS="cgtacattacttgcttctttcatcaaggaaGCAGGAAGAcct ttaagcggTGTAGAATTAGCACCAATGatggcaaccgcgtctttgcgtccaaggcttg c" /listShort="S449, yjlA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1246682 /Source="Nicolas_upshifts" /id="U1007" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.59040959040959" /psig="0.015984015984016" /xcortree=1732 /SigmaFactorBS="tcaagccagtaaactctggtacacttgcaagccttggacgca aagacgcggttgccatcattggtgctaattctacaccgcttaaaggtcttcctgcttc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1246688) /Source="Nicolas_upshifts" /id="U1008" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=506 /SigmaFactorBS="cgtacattacttgcttctttcatcaaggaaGCAGGAAGAcct ttaagcggTGTAGAATTAGCACCAATGatggcaaccgcgtctttgcgtccaaggcttg c" /listShort="S449, yjlA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1246710..1246718) /Source="Nicolas_upshift_promotors" /id="U1008" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=506 /SigmaFactorBS="cgtacattacttgcttctttcatcaaggaaGCAGGAAGAcct ttaagcggTGTAGAATTAGCACCAATGatggcaaccgcgtctttgcgtccaaggcttg c" /listShort="S449, yjlA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1246790 /Source="Nicolas_upshifts" /id="D684" /incds=0 /nref=220 /ntot=278 /MaxReadThrough="2.01042" /MaxDrop="8.69373" /score="30.6421047" /energy="-23.1" /TU="NA" /idTUdmin="U1005" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 1246899..1246906 /Source="Nicolas_upshift_promotors" /id="U1009" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.694305694305694" /psig="0.935064935064935" /xcortree=1573 /SigmaFactorBS="ttttcaaaaaagaGATTGATCccaaaggaatataaAGGTAAA ATAAAAACAAATCaaaatgttaacgttaacattttgaaatagaatgaaagacggtgag g" /listShort="uxaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1246921..1246940 /Source="Nicolas_upshift_promotors" /id="U1009" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.694305694305694" /psig="0.935064935064935" /xcortree=1573 /SigmaFactorBS="ttttcaaaaaagaGATTGATCccaaaggaatataaAGGTAAA ATAAAAACAAATCaaaatgttaacgttaacattttgaaatagaatgaaagacggtgag g" /listShort="uxaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1246946 /Source="Nicolas_upshifts" /id="U1009" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.694305694305694" /psig="0.935064935064935" /xcortree=1573 /SigmaFactorBS="ttttcaaaaaagaGATTGATCccaaaggaatataaAGGTAAA ATAAAAACAAATCaaaatgttaacgttaacattttgaaatagaatgaaagacggtgag g" /listShort="uxaC" /GFF_Attribute="listLong" /label="upshifts" CDS 1246989..1248410 /gene="uxaC" /locus_tag="BSU_12300" /old_locus_tag="BSU12300" /EC_number="5.3.1.12" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9579062, 9882655; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="galacturonate isomerase" /protein_id="NP_389112.1" /db_xref="EnsemblGenomes-Gn:BSU12300" /db_xref="EnsemblGenomes-Tr:CAB13087" /db_xref="GOA:O34808" /db_xref="InterPro:IPR003766" /db_xref="InterPro:IPR032466" /db_xref="SubtiList:BG13204" /db_xref="UniProtKB/Swiss-Prot:O34808" /translation="MEPFMGKNFLLKNETAVSLYHNYAKDMPIIDYHCHLSPKEIYEN KTFQNITEAWLYGDHYKWRIMRANGIEETYITGDAPDEEKFMAWAKTVPMAIGNPLYN WTHLELQRFFGIYEILNEKSGSAIWKQTNKLLKGEGFGARDLIVKSNVKVVCTTDDPV DSLEYHLLLKEDKDFPVSVLPGFRPDKGLEINREGFPEWVQALEDAAAISITTYDEFL KALEKRVRFFHSAGGRVSDHAIDTMVFAETTKEEAGRIFSDRLQGTEVSCEDEKKFKT YTLQFLCGLYAELDWAMQFHINALRNTNTKMMKRLGPDTGYDSMNDEEIAKPLYKLLN SVEMKNQLPKTILYSLNPNDNYVIASMINSFQDGITPGKIQFGTAWWFNDTKDGMLDQ MKALSNVGLFSRFIGMLTDSRSFLSYTRHEYFRRIVCNLIGEWVENGEVPRDMELLGS IVQGICYDNAKHYFQFQEEKANV*" /label="uxaC CDS" gene 1246989..1248410 /gene="uxaC" /locus_tag="BSU_12300" /old_locus_tag="BSU12300" /label="uxaC gene" CDS 1248478..1249857 /gene="exuM" /locus_tag="BSU_12310" /old_locus_tag="BSU12310" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9882655, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na+:altronate/mannonate symporter" /protein_id="NP_389113.1" /db_xref="EnsemblGenomes-Gn:BSU12310" /db_xref="EnsemblGenomes-Tr:CAB13088" /db_xref="GOA:O34961" /db_xref="InterPro:IPR001927" /db_xref="InterPro:IPR018043" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13205" /db_xref="UniProtKB/Swiss-Prot:O34961" /translation="MRTELANKVVSVETEKRLSLKEKMSYGFGDFGNGFMFDLGQIYL LKYFTDVAGIPAAMAGGIFLVSKLFAAITDPIVGSSIDYRKNIGKRGKFRPYLLIGSI VLAVLTVLIFLSPNVSTTGKLIYAYASYMIWGIGYSFVNIPYGSLGAAMTQNSEDRTS ISTFRQIGSLGALFITSVAVMPLLVKFDNPKVGYPVVMGLFAALGVFWFYICYRNCKE RIIISEAPKEKLTLSSVVKTFITNKPLLTLVLMTIFSISAYNIKSAMLVYFAQYNLGN VELMAYMNFIIIGSSFLGVVFLPKLVKMFGKKRTAMIGFGISVAADLINFMLPSNVYV FTILASIAFIGISIPNGITWALVSDIIDYGEWKSGERKEATTYSLFNFSRKLAQSLSG FLSGIGLGIIGYVPNAVQTAQALIGIKALLLLYPAIALALAMFIIGFLYKLTDQQHAQ IVQDLHQKS*" /label="exuM CDS" gene 1248478..1249857 /gene="exuM" /locus_tag="BSU_12310" /old_locus_tag="BSU12310" /label="exuM gene" promotor_-10 complement(1248997..1249016) /Source="Nicolas_upshift_promotors" /id="U1010" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.988011988011988" /psig="0.999000999001" /xcortree=2077 /SigmaFactorBS="cgggtagccgaccttcggattatcaAACTTGACgagcagcgg catcACGGCCACACTTGTGATAAAcaaggcgccaagtgatccgatttggcggaacgtc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1249002) /Source="Nicolas_upshifts" /id="U1010" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.988011988011988" /psig="0.999000999001" /xcortree=2077 /SigmaFactorBS="cgggtagccgaccttcggattatcaAACTTGACgagcagcgg catcACGGCCACACTTGTGATAAAcaaggcgccaagtgatccgatttggcggaacgtc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1249030..1249037) /Source="Nicolas_upshift_promotors" /id="U1010" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.988011988011988" /psig="0.999000999001" /xcortree=2077 /SigmaFactorBS="cgggtagccgaccttcggattatcaAACTTGACgagcagcgg catcACGGCCACACTTGTGATAAAcaaggcgccaagtgatccgatttggcggaacgtc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1249882 /Source="Nicolas_upshifts" /id="U1011" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.926073926073926" /psig="0.926073926073926" /xcortree=1048 /SigmaFactorBS="gctcagatcgttcaggatcttcatcaaaagagctgacaatat aatataaagaatatttaaaataatttgtAAATAAAAtgtgtttgtaggggtttcgctt g" /listShort="S452, yjmC, yjmD, uxuA, uxuB, exuT, exuR" /GFF_Attribute="listLong" /label="upshifts" misc_feature 1249892..1249899 /Source="Nicolas_upshift_promotors" /id="U1011" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.926073926073926" /psig="0.926073926073926" /xcortree=1048 /SigmaFactorBS="gctcagatcgttcaggatcttcatcaaaagagctgacaatat aatataaagaatatttaaaataatttgtAAATAAAAtgtgtttgtaggggtttcgctt g" /listShort="S452, yjmC, yjmD, uxuA, uxuB, exuT, exuR" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1249894..1249961 /Source="Nicolas_S_feature" /locus_tag="new_1303355_1303422" /HighExp="S4, S5, S6, S3, S8, S7, T5.0H, T4.0H, T3.30H, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.926" /TUlongSig="NA" /TUlongPSig="NA" /label="S452" CDS 1249962..1250975 /gene="yjmC" /locus_tag="BSU_12320" /old_locus_tag="BSU12320" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9579062, 9882655, 16788182; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_389114.1" /db_xref="EnsemblGenomes-Gn:BSU12320" /db_xref="EnsemblGenomes-Tr:CAB13089" /db_xref="GOA:O34736" /db_xref="InterPro:IPR003767" /db_xref="InterPro:IPR036111" /db_xref="SubtiList:BG13206" /db_xref="UniProtKB/Swiss-Prot:O34736" /translation="MKTITIAAEEAKELVWQKLDGAGLNERDAEKVADVLVHADLRNV HSHGVLHTEHYVNRLLAGGINPGAQPVFKETGPVTGVLDGDDGFGHVNCDMAMDHAID MAKKKGVGMVTAVNSSHCGALSYFVQKAADEKLIGMAMTHTDSIVVPFGGRTPILGTN PIAYGVPAKHKKPFILDMATSKVAFGKILQAREEGKEIPEGWGVDENGEAVTDPDKVV SLSTFGGPKGYGLSIVVDVFSGLLAGAAFGPHIAKMYNGLDQKRKLGHYVCAINPSFF TDWDTFLEQMDAMIDELQQSPPAVGFERVYVPGEIEQLHEERNKKNGISIARSVYEFL KSR*" /label="yjmC CDS" gene 1249962..1250975 /gene="yjmC" /locus_tag="BSU_12320" /old_locus_tag="BSU12320" /label="yjmC gene" CDS 1250981..1252000 /gene="yjmD" /locus_tag="BSU_12330" /old_locus_tag="BSU12330" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9579062, 9882655; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_389115.1" /db_xref="EnsemblGenomes-Gn:BSU12330" /db_xref="EnsemblGenomes-Tr:CAB13090" /db_xref="GOA:O35045" /db_xref="InterPro:IPR002328" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13207" /db_xref="UniProtKB/Swiss-Prot:O35045" /translation="MKAVQVRKAYDLVTAEVKKPVLSKDDEVLVKVKRVGICGSDMHI YHGTNPLATLPRVIGHEVTGQVEAVGANVQSLKPGDHVVIEPISYCGSCYACRKGRPN VCAKLSVFGVHEDGGMREYIVLPERQLHAVSKDLPWEEAVMAEPYTIGAQAVWRGQVE KGDTVLIQGAGPIGICVLKMAKLAGAAVMMTDLNNERLAFAKENGADAVVNVQAEHVA ERVLEWTGNEGANVVIDAVCLPETFALSIEAVSPAGHVVVLGFDERAAQISQLPITKK EVTITGSRLQTNQFPKVVELLNGGRLMHNGLVTHTFSVDDVHHAFQFIKEHPDQVRKA VITFD*" /label="yjmD CDS" gene 1250981..1252000 /gene="yjmD" /locus_tag="BSU_12330" /old_locus_tag="BSU12330" /label="yjmD gene" CDS 1252025..1253104 /gene="uxuA" /locus_tag="BSU_12340" /old_locus_tag="BSU12340" /EC_number="4.2.1.8" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 9579062, 9882655, 10368143, 25145794; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-mannonate dehydratase" /protein_id="NP_389116.1" /db_xref="EnsemblGenomes-Gn:BSU12340" /db_xref="EnsemblGenomes-Tr:CAB13091" /db_xref="GOA:O34346" /db_xref="InterPro:IPR004628" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG13208" /db_xref="UniProtKB/Swiss-Prot:O34346" /translation="MNMTFRWYGRGNDTVTLEYVKQIPGVKGIVWALHQKPVGDVWEK EEIRAETEYIQSYGFHAEVVESVNVHEAIKLGNEERGRYIENYKQTIRNLAGFGVKVI CYNFMPVFDWTRTDMFRPLEDGSTALFFEKAKVESLDPQELIRTVEEASDMTLPGWEP EKLARIKELFAAYRTVDEEKLWDNLSFFLQEILPVAEAYGVQMAIHPDDPPWPIFGLP RIITGEASYKKLRAISDSPSNCITLCTGSMGANPANDMVEIAKTYAGIAPFSHIRNVK IYENGDFIETSHLTKDGSINIQGVMEELHKQDYEGYVRPDHGRHLWGEQCRPGYGLYD RALGIMYLNGLWDAYEAMAKKEVGI*" /label="uxuA CDS" gene 1252025..1253104 /gene="uxuA" /locus_tag="BSU_12340" /old_locus_tag="BSU12340" /label="uxuA gene" CDS 1253101..1253937 /gene="uxuB" /locus_tag="BSU_12350" /old_locus_tag="BSU12350" /EC_number="1.1.1.57" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9579062, 9882655, 10368143; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fructuronate reductase" /protein_id="NP_389117.1" /db_xref="EnsemblGenomes-Gn:BSU12350" /db_xref="EnsemblGenomes-Tr:CAB13092" /db_xref="GOA:O34896" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13209" /db_xref="UniProtKB/Swiss-Prot:O34896" /translation="MIPLHENLAGKTAVITGGSGVLCSAMARELARHGMKVAILNRTA EKGQAVVKEITAAGGTACAVAADVLDRMSLERAKEDILGQFGAVDLLINGAGGNHPDA ITDVETYEEAGEGQSFFDMDERGFLTVFSTNFTGAFLASQVFGKELLKADSPAIINLS SMSAYSPMTKVPAYSAAKASINNFTMWMAVHFAETGLRVNAIAPGFFLTKQNHDLLIN QDGTFTSRSHKIIAGTPMKRFGKPEDLLGTLLWLADESYSGFVTGITVPVDGGFMAYS GV*" /label="uxuB CDS" gene 1253101..1253937 /gene="uxuB" /locus_tag="BSU_12350" /old_locus_tag="BSU12350" /label="uxuB gene" CDS 1253985..1255253 /gene="exuT" /locus_tag="BSU_12360" /old_locus_tag="BSU12360" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8320243, 9579062, 9882655, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="hexuronate transporter" /protein_id="NP_389118.1" /db_xref="EnsemblGenomes-Gn:BSU12360" /db_xref="EnsemblGenomes-Tr:CAB13093" /db_xref="GOA:O34456" /db_xref="InterPro:IPR000849" /db_xref="InterPro:IPR004744" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13210" /db_xref="UniProtKB/Swiss-Prot:O34456" /translation="MFSKDKLPVILFLFLAGVINYLDRSALSIAAPFIQDDLTLSATQ MGLIFSSFSIGYAIFNFLGGVASDRYGAKLTLFVAMVVWSLFSGAVALAFGFVSLLII RILFGMGEGPLSATINKMVNNWFPPTQRASVIGVTNSGTPLGGAISGPIVGMIAVAFS WKVSFVLIMIIGLIWAVLWFKFVKEKPQETIKEAPAIKAETSPGEKIPLTFYLKQKTV LFTAFAFFAYNYILFFFLTWFPSYLVDERGLSVESMSVITVIPWILGFIGLAAGGFVS DYVYKKTARKGVLFSRKVVLVTCLFSSAVLIGFAGLVATTAGAVTLVALSVFFLYLTG AIYWAVIQDVVDQNNVGSVGGFMHFLANTAGIIGPALTGFIVDQTGTFSGAFLLAGGL AVFASLAVIRFVRPIIGKPAGTEAENPVSY*" /label="exuT CDS" gene 1253985..1255253 /gene="exuT" /locus_tag="BSU_12360" /old_locus_tag="BSU12360" /label="exuT gene" promotor_-35 1255197..1255200 /Source="Nicolas_upshift_promotors" /id="U1012" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.637362637362637" /psig="0.005994005994006" /xcortree=1486 /SigmaFactorBS="ctggctgtcttcgcttcacttgctgtgattcgttttgtcCGT CcaatcattggtaagcCAGCGggaacagaagctgagaatcctgtgtcttattaatctg g" /listShort="exuR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1255216..1255220 /Source="Nicolas_upshift_promotors" /id="U1012" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.637362637362637" /psig="0.005994005994006" /xcortree=1486 /SigmaFactorBS="ctggctgtcttcgcttcacttgctgtgattcgttttgtcCGT CcaatcattggtaagcCAGCGggaacagaagctgagaatcctgtgtcttattaatctg g" /listShort="exuR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1255218 /Source="Nicolas_upshifts" /id="U1012" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.637362637362637" /psig="0.005994005994006" /xcortree=1486 /SigmaFactorBS="ctggctgtcttcgcttcacttgctgtgattcgttttgtcCGT CcaatcattggtaagcCAGCGggaacagaagctgagaatcctgtgtcttattaatctg g" /listShort="exuR" /GFF_Attribute="listLong" /label="upshifts" misc_feature 1255286..1255305 /Source="Nicolas_upshift_promotors" /id="U1013" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.966033966033966" /psig=1 /xcortree=3107 /SigmaFactorBS="agaagctgagaatcctgtgtcttattaatctggaaatatagt gggagaggcggtatgtttGATGATACAATATACAGTAAataatcgcagccggtatgat a" /listShort="exuR" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1255286 /Source="Nicolas_upshifts" /id="U1013" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.966033966033966" /psig=1 /xcortree=3107 /SigmaFactorBS="agaagctgagaatcctgtgtcttattaatctggaaatatagt gggagaggcggtatgtttGATGATACAATATACAGTAAataatcgcagccggtatgat a" /listShort="exuR" /GFF_Attribute="listLong" /label="upshifts" CDS 1255341..1256342 /gene="exuR" /locus_tag="BSU_12370" /old_locus_tag="BSU12370" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9579062, 9882655" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9579062, 9882655; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (LacI family)" /protein_id="NP_389119.1" /db_xref="EnsemblGenomes-Gn:BSU12370" /db_xref="EnsemblGenomes-Tr:CAB13094" /db_xref="GOA:Q9JMQ1" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG13211" /db_xref="UniProtKB/Swiss-Prot:Q9JMQ1" /translation="MVTIKDIAKLANVSHTTVSRALNNSPYIKEHTKKKILELAEQLN YTPNVNAKSLAMQKSHTIGLFFTSITNGTSHSFFADTIKGVNQAISEDYNLYVRGIDD LKNYDSVTPMRYDGIILMSQSDIDNSFIYHIREKNIPLVVLNRDIDDRTITNILSNDK EGSQEAVEYFIQSGHQDIAIIEGIEGFKSSQQRKEGYLSALIQHHIPIKHEYSVKGQY DMESGFQAMERLLALPNPPTAVFCSNDDMAIGAMNAIFAKGLRVPDDISVIGFDDIGF SQYITPRLSTVKRPVEKISVLGAQKLLSLISEPETKAEKILENTEFMVRDSVRRLTT* " /label="exuR CDS" gene 1255341..1256342 /gene="exuR" /locus_tag="BSU_12370" /old_locus_tag="BSU12370" /label="exuR gene" promotor_no_box complement(1256024..1256124) /Source="Nicolas_upshift_promotors" /id="U1014" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.915084915084915" /psig="0.024975024975025" /xcortree=19 /SigmaFactorBS="cgcgcaggccctttgcgaatatcgcattcatcgctccgattg ccatgtcatcattcgaacaaaaaacagcggttggaggattcggcagtgccagcagccg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1256064) /Source="Nicolas_upshifts" /id="U1014" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.915084915084915" /psig="0.024975024975025" /xcortree=19 /SigmaFactorBS="cgcgcaggccctttgcgaatatcgcattcatcgctccgattg ccatgtcatcattcgaacaaaaaacagcggttggaggattcggcagtgccagcagccg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1256318 /Source="Nicolas_upshifts" /id="D685" /incds=0 /nref=2 /ntot=132 /MaxReadThrough="2.47166" /MaxDrop="3.11543" /score="12.2153519" /energy="-7.4" /TU="NA" /idTUdmin="U1011" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 1256419..1257861 /gene="uxaB" /locus_tag="BSU_12380" /old_locus_tag="BSU12380" /EC_number="1.1.1.58" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9579062, 9882655; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tagaturonate reductase (altronate oxidoreductase)" /protein_id="NP_389120.1" /db_xref="EnsemblGenomes-Gn:BSU12380" /db_xref="EnsemblGenomes-Tr:CAB13095" /db_xref="GOA:O34354" /db_xref="InterPro:IPR000669" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013118" /db_xref="InterPro:IPR013131" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR023668" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13212" /db_xref="UniProtKB/Swiss-Prot:O34354" /translation="MQKLNKNVYDHYTQYPEKILQFGEGNFLRGFIDWQIDQLNQHTD FNGSVAVVQPRGSEKIKRLNEQDGLYTLFLQGMKDGEAVNEHMIINSISRGIDLFSDY EAYKELASSERLRFIISNTTEAGIVCDEKDRLEDRPQKTFPGKLTAFLYFRYQAFKGD QTKGCVLIPCELIENNGEKLRETVLHYAHLWKLEEGFTQWIHEANTFCNSLVDRIVPG FPVDSIDEITADLGYQDDLIVVGEQYYLWVIEGPDWIGKELPFAAAGLHTKIVSDLTP YRTKKVRILNGAHTAMTPVALLYGLKTVRDAVEHPEVGRFIRELIDDEILPVLKMEGL SQYADDVLNRFKNPYIKHYLESIALNAISKFKTRNLPTLKEYAEQKGQLPERLVFSFS ALLYFYHDNETLQDDPAVLQFFKEVWCQEDGDMLRIASRVLGEQRLWGADLNEIPKLT DRVAVYLNHIHELGMQRALEQYCIQGGEVR*" /label="uxaB CDS" gene 1256419..1257861 /gene="uxaB" /locus_tag="BSU_12380" /old_locus_tag="BSU12380" /label="uxaB gene" CDS 1257858..1259351 /gene="uxaA" /locus_tag="BSU_12390" /old_locus_tag="BSU12390" /EC_number="4.2.1.7" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9579062, 9882655; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="altronate dehydratase" /protein_id="NP_389121.2" /db_xref="EnsemblGenomes-Gn:BSU12390" /db_xref="EnsemblGenomes-Tr:CAB13096" /db_xref="GOA:O34673" /db_xref="InterPro:IPR007392" /db_xref="InterPro:IPR013974" /db_xref="SubtiList:BG13213" /db_xref="UniProtKB/Swiss-Prot:O34673" /translation="MKSFIKIHKQDNVLLALRDIQKGERLHAYGVSIEVKDDIKRGHK IALQSIKENDSIVKYGFPIGHASQDISIGEHIHVHNTKTNLSDIQLYSYTPRFDENPY SNENRTFKGFRRENGDAGVRNELWIVPTVGCVNGIAEKMLQRFVRETGDIAPFDNVLV LKHQYGCSQLGDDHENTKQILLNAIRHPNAGGVLVLGLGCENNELARMKEALQDVNLK RVKFLESQSVTDEMEAGVALLKEIHEAAKGDKREDIPLSELKIGLKCGGSDGFSGITA NPLLGRFSDYLIAQGGSTVLTEVPEMFGAETILMQRAANEEVFHKIVDLINDFKQYFI KHDQPVYENPSPGNKAGGISTLEDKSLGCTQKAGISPVTDVLKYGEVLKTKGLTLLSA PGNDLIASSALAAAGCQIVLFTTGRGTPFGTFVPTVKVATNTELYEAKPHWIDFNAGL LAEDDVHEEYVLREFIHYMIEVASGQLVNHEKNDFKELAIFKSGVTL*" /label="uxaA CDS" gene 1257858..1259351 /gene="uxaA" /locus_tag="BSU_12390" /old_locus_tag="BSU12390" /label="uxaA gene" CDS complement(1259390..1260154) /gene="yjnA" /locus_tag="Delta6_BSU_12400_SNPvariant" /old_locus_tag="BSU_12400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 16885442; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_389122.1" /db_xref="EnsemblGenomes-Gn:BSU12400" /db_xref="EnsemblGenomes-Tr:CAB13097" /db_xref="GOA:O34578" /db_xref="InterPro:IPR002781" /db_xref="SubtiList:BG13214" /db_xref="UniProtKB/Swiss-Prot:O34578" /modified_by="User" /translation="MSVSIILMGLFVGALVGLTGVGGAALLTPLLIVLGINPSIAVGT DLVYNSITKLFGVASHWRQKTINFKLVKYLAIGGIPSASLAIGILHLFPAFHQHQEEI IKHALGYVLTLVAISIIVRLFLDRKLRPNRWQLMPLENKRALTILIGVVFGFIVGLTS IGSGSLFAIAMIYLFNMKASQIVGTDIAHAFLLVTAAGILNASFGSVDYMLAANLLLG SIPGVLIGSHLSPRFSPRPLQFIMASIILVSGLKLI*" /label="Delta6_BSU_12400_SNPvariant" gene complement(1259390..1260154) /gene="yjnA" /locus_tag="Delta6_BSU_12400_SNPvariant" /old_locus_tag="BSU_12400" /modified_by="User" /label="Delta6_BSU_12400_SNPvariant" downshifts complement(1259409) /Source="Nicolas_upshifts" /id="D686" /incds=0 /nref=96 /ntot=170 /MaxReadThrough="1.34004" /MaxDrop="4.60564" /score="6.47747687" /energy="-11.3" /TU="NA" /idTUdmin="U1015" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" Polymorphism join(1259922,1259924) /Source="geneious" /ID="SNP_BsDelta6_1313384_1313384" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change="S -> G" /CDS_Position=232 /Change="T -> C" /Codon_Change="AGT -> GGT" /Coverage=150 /locus_tag="BSU_12400" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides="C" /Variant_P_Value=0 /Variant_Raw_Frequency=149 /comment="Delta6_BSU_12400_SNPvariant" /modified_by="User" / /label="Polymorphism_Delta6" SCAR join(1260181,1260188) /created_by="User" /modified_by="User" /label="TF8A" N_region 1260182..1260187 /created_by="User" /note_="EcoRI site (GAATTC)" /modified_by="User" /label="TF8A" CDS <1260190..1260510 /gene="xlyA" /locus_tag="Delta6_pseudo_BSU_12810" /old_locus_tag="BSU12810" /EC_number="3.5.1.28" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:7921239, 9555893" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7921239, 9555893; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="phage PBSX; N-acetylmuramoyl-L-alanine amidase" /protein_id="NP_389164.1" /db_xref="EnsemblGenomes-Gn:BSU12810" /db_xref="EnsemblGenomes-Tr:CAB13138" /db_xref="GOA:P39800" /db_xref="InterPro:IPR002477" /db_xref="InterPro:IPR002502" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036365" /db_xref="InterPro:IPR036366" /db_xref="InterPro:IPR036505" /db_xref="InterPro:IPR036779" /db_xref="PDB:3HMB" /db_xref="PDB:3RDR" /db_xref="SubtiList:BG10962" /db_xref="UniProtKB/Swiss-Prot:P39800" /NCBI_locus_tag="A8O17_RS06625" /modified_by="User" /translation="PNLIRVGQVLIVSAPSAAEKPELYPLPDGIIQLTTPYTSGEHVF QVQRALAALYFYPDKGAVNNGIDGVYGPKTADAVARFQSVNGLTADGIYGPATKEKIA AQLS*" /label="Delta6_pseudo_BSU_12810" gene <1260190..1260510 /gene="xlyA" /locus_tag="Delta6_pseudo_BSU_12810" /old_locus_tag="BSU12810" /NCBI_locus_tag="A8O17_RS06625" /modified_by="User" /label="Delta6_pseudo_BSU_12810" downshifts 1260519 /Source="Nicolas_upshifts" /id="D696" /incds=0 /nref=29 /ntot=162 /MaxReadThrough="3.77255" /MaxDrop="5.00305" /score="30.9009227" /energy="-12.5" /TU="U1029,U1033" /idTUdmin="U1029" /TUdmin="-152" /isTUend="FALSE" /label="downshifts" S_feature complement(1260528..1260731) /Source="Nicolas_S_feature" /locus_tag="new_1348200_1348403_c" /HighExp="S8, S6, S7, BT, B36, S5, S4, G/S, Pyr, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 0.798" /TUlongSig="NA" /TUlongPSig="NA" /label="S458" CDS complement(1260547..1260684) /gene="spoIISC" /locus_tag="BSU_12815" /old_locus_tag="BSU12815" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11371520, 18096016, 20863891, 21147767, 25039482, 26300872, 27294956; Product type r: regulator" /codon_start=1 /transl_table=11 /product="three component toxin / antitoxin / antitoxin SpoIISABC, antitoxin C" /protein_id="YP_009513952.1" /translation="MSGDTVKKLVRRVKFVDYGRFGLSGYSLRVRERSAGIIKKLKKK K*" /label="spoIISC CDS" gene complement(1260547..1260684) /gene="spoIISC" /locus_tag="BSU_12815" /old_locus_tag="BSU12815" /label="spoIISC gene" downshifts complement(1260571) /Source="Nicolas_upshifts" /id="D697" /incds=0 /nref=31 /ntot=215 /MaxReadThrough="2.75573" /MaxDrop="4.3776" /score="24.0186344" /energy="-12.5" /TU="U1034" /idTUdmin="U1035" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1260770..1260940) /gene="spoIISB" /locus_tag="BSU_12820" /old_locus_tag="BSU12820" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11371520, 18096016, 20863891, 21147767, 25039482, 26300872, 27294956" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11371520, 18096016, 20863891, 21147767, 25039482, 26300872, 27294956; Product type f: factor" /codon_start=1 /transl_table=11 /product="three-component apoptotic control system component B (antitoxin B)" /protein_id="NP_389165.1" /db_xref="EnsemblGenomes-Gn:BSU12820" /db_xref="EnsemblGenomes-Tr:CAB13139" /db_xref="GOA:O34800" /db_xref="InterPro:IPR025897" /db_xref="PDB:3O6Q" /db_xref="SubtiList:BG12678" /db_xref="UniProtKB/Swiss-Prot:O34800" /translation="MERAFQNRCEPRAAKPFKILKKRSTTSVASYQVSPHTARIFKEN ERLIDEYKRKKA*" /label="spoIISB CDS" gene complement(1260770..1260940) /gene="spoIISB" /locus_tag="BSU_12820" /old_locus_tag="BSU12820" /label="spoIISB gene" downshifts complement(1260776) /Source="Nicolas_upshifts" /id="D698" /incds=0 /nref=6 /ntot=86 /MaxReadThrough="4.69899" /MaxDrop="3.0872" /score="24.0186344" /energy="-12.5" /TU="U1034,U1035" /idTUdmin="U1035" /TUdmin="-205" /isTUend="FALSE" /label="downshifts" CDS complement(1260940..1261686) /gene="spoIISA" /locus_tag="BSU_12830" /old_locus_tag="BSU12830" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11371520, 18096016, 20863891, 21147767, 25039482, 26300872, 27294956" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11371520, 18096016, 20863891, 21147767, 25039482, 26300872, 27294956; Product type f: factor" /codon_start=1 /transl_table=11 /product="three-component apoptosis factor (ABC toxin/antitoxin/antitoxin system)" /protein_id="NP_389166.1" /db_xref="EnsemblGenomes-Gn:BSU12830" /db_xref="EnsemblGenomes-Tr:CAB13140" /db_xref="GOA:O34853" /db_xref="InterPro:IPR025940" /db_xref="PDB:3O6Q" /db_xref="SubtiList:BG12677" /db_xref="UniProtKB/Swiss-Prot:O34853" /translation="MVLFFQIMVWCIVAGLGLYVYATWRFEAKVKEKMSAIRKTWYLL FVLGAMVYWTYEPTSLFTHWERYLIVAVSFALIDAFIFLSAYVKKLAGSELETDTREI LEENNEMLHMYLNRLKTYQYLLKNEPIHVYYGSIDAYAEGIDKLLKTYADKMNLTASL CHYSTQADKDRLTEHMDDPADVQTRLDRKDVYYDQYGKVVLIPFTIETQNYVIKLTSD SIVTEFDYLLFTSLTSIYDLVLPIEEEGEG*" /label="spoIISA CDS" gene complement(1260940..1261686) /gene="spoIISA" /locus_tag="BSU_12830" /old_locus_tag="BSU12830" /label="spoIISA gene" promotor_-10 complement(1261521..1261540) /Source="Nicolas_upshift_promotors" /id="U1034" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.724275724275724" /psig=1 /xcortree=623 /SigmaFactorBS="tcaaagaaaaaatgtccgccattcggaaaacttggTATTTGC TgtttgttctgggcgcTATGGTATACTGGACATATGagcccacttccctatttaccca c" /listShort="spoIISB, S458" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1261538) /Source="Nicolas_upshifts" /id="U1034" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.724275724275724" /psig=1 /xcortree=623 /SigmaFactorBS="tcaaagaaaaaatgtccgccattcggaaaacttggTATTTGC TgtttgttctgggcgcTATGGTATACTGGACATATGagcccacttccctatttaccca c" /listShort="spoIISB, S458" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1261556..1261563) /Source="Nicolas_upshift_promotors" /id="U1034" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.724275724275724" /psig=1 /xcortree=623 /SigmaFactorBS="tcaaagaaaaaatgtccgccattcggaaaacttggTATTTGC TgtttgttctgggcgcTATGGTATACTGGACATATGagcccacttccctatttaccca c" /listShort="spoIISB, S458" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1261712..1261730) /Source="Nicolas_upshift_promotors" /id="U1035" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.798201798201798" /psig="0.798201798201798" /xcortree=1112 /SigmaFactorBS="cttctgtcaaaggagcggtttttttgatggaacaGGAAAAcc atccggatctctcGAATACAATAAGCAGAACCtatttcagatgtgagggattcgaata t" /listShort="spoIISA, spoIISB, S458" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1261725) /Source="Nicolas_upshifts" /id="U1035" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.798201798201798" /psig="0.798201798201798" /xcortree=1112 /SigmaFactorBS="cttctgtcaaaggagcggtttttttgatggaacaGGAAAAcc atccggatctctcGAATACAATAAGCAGAACCtatttcagatgtgagggattcgaata t" /listShort="spoIISA, spoIISB, S458" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1261746..1261751) /Source="Nicolas_upshift_promotors" /id="U1035" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.798201798201798" /psig="0.798201798201798" /xcortree=1112 /SigmaFactorBS="cttctgtcaaaggagcggtttttttgatggaacaGGAAAAcc atccggatctctcGAATACAATAAGCAGAACCtatttcagatgtgagggattcgaata t" /listShort="spoIISA, spoIISB, S458" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1261796..1262797) /gene="pitB" /locus_tag="BSU_12840" /old_locus_tag="BSU12840" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 10784039, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative low-affinity inorganic phosphate transporter" /protein_id="NP_389167.2" /db_xref="EnsemblGenomes-Gn:BSU12840" /db_xref="EnsemblGenomes-Tr:CAB13141" /db_xref="GOA:O34436" /db_xref="InterPro:IPR001204" /db_xref="SubtiList:BG13226" /db_xref="UniProtKB/Swiss-Prot:O34436" /translation="MDILLILTILIVICALAFDFINGFHDTANAIATSVSTKALKPRH AIILAAVMNFVGAMTFTGVAKTITKDIVDPYTLENGSVVILAALLAAIAWNLITWYYG IPSSSSHAIIGAIAGAAIAAAGFAALNYKGFIKIIEALILSPIIAFVLGFILYSIVKL IFKDSNLAKTNKQFRRVQIVTAALQSYTHGTNDAQKAMGIITMALITANLHTSANDIP TWVQFACATAMGLGTSIGGWKIIKTVGGKIMKIRPVNGVSADLTGAAIIFGATFIHLP VSTTHVISSSILGVGASHRVKGVNWGTAKRMLITWVITLPISATLGAIAYFILNMIF* " /label="pitB CDS" gene complement(1261796..1262797) /gene="pitB" /locus_tag="BSU_12840" /old_locus_tag="BSU12840" /label="pitB gene" downshifts complement(1261825) /Source="Nicolas_upshifts" /id="D699" /incds=0 /nref=205 /ntot=253 /MaxReadThrough="3.49591" /MaxDrop="5.81942" /score="21.8061263" /energy="-11" /TU="U1036,U1038" /idTUdmin="U1037" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1262810..1263427) /gene="ykaA" /locus_tag="BSU_12850" /old_locus_tag="BSU12850" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9696772, 14563871; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative PitB transporter accessory protein" /protein_id="NP_389168.1" /db_xref="EnsemblGenomes-Gn:BSU12850" /db_xref="EnsemblGenomes-Tr:CAB13142" /db_xref="InterPro:IPR018445" /db_xref="SubtiList:BG13225" /db_xref="UniProtKB/Swiss-Prot:O34454" /translation="MIRRKKDKFSLLLTEIAKNIDETAEYFVNFKVTNQTTLKEFADT LKEYETKGDNHVHVMIKELNKAFITPIEREDILQLTNSLDDVLDGIEHFSAMMEIFSI TSSDEHIDKFSGYIRECAKEILITIELLAENRLKDIQPHAIKIKEYEHSCDNLHRKSL KNLFGNETDPIKVIQYREIYETLEEIADSCQSVANNLETIIMKNA*" /label="ykaA CDS" gene complement(1262810..1263427) /gene="ykaA" /locus_tag="BSU_12850" /old_locus_tag="BSU12850" /label="ykaA gene" promotor_-10 complement(1263463..1263482) /Source="Nicolas_upshift_promotors" /id="U1036" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig="0.996003996003996" /xcortree=2607 /SigmaFactorBS="aagatacgtttttttcgactttaCCTGTtttttttcgacaaa aGGCTATATAATAATTTGATGtgtgcattgttcattcaaactatggagggtttttaat g" /listShort="ykaA, pit" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1263465) /Source="Nicolas_upshifts" /id="U1036" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig="0.996003996003996" /xcortree=2607 /SigmaFactorBS="aagatacgtttttttcgactttaCCTGTtttttttcgacaaa aGGCTATATAATAATTTGATGtgtgcattgttcattcaaactatggagggtttttaat g" /listShort="ykaA, pit" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1263467..1263564) /Source="Nicolas_S_feature" /locus_tag="new_1351139_1351236_c" /HighExp="H2O2, Etha, dia15, Diami, Paraq, Heat, dia5, Salt, LBGstat, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.972, 0.987" /TUlongSig="SigA" /TUlongPSig="0.992" /label="S459" promotor_-35 complement(1263498..1263502) /Source="Nicolas_upshift_promotors" /id="U1036" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig="0.996003996003996" /xcortree=2607 /SigmaFactorBS="aagatacgtttttttcgactttaCCTGTtttttttcgacaaa aGGCTATATAATAATTTGATGtgtgcattgttcattcaaactatggagggtttttaat g" /listShort="ykaA, pit" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1263544..1263563) /Source="Nicolas_upshift_promotors" /id="U1037" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig="0.972027972027972" /xcortree=641 /SigmaFactorBS="atatactttttacgttaagcagaaagtttttgcaaacttGGG TCGTTtttttaaagcgaagTAGGTCAAAATAAGGAGACAcgatttatcaaaaaagtca a" /listShort="S459, ykaA, pit" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1263564) /Source="Nicolas_upshifts" /id="U1037" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig="0.972027972027972" /xcortree=641 /SigmaFactorBS="atatactttttacgttaagcagaaagtttttgcaaacttGGG TCGTTtttttaaagcgaagTAGGTCAAAATAAGGAGACAcgatttatcaaaaaagtca a" /listShort="S459, ykaA, pit" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1263578..1263585) /Source="Nicolas_upshift_promotors" /id="U1037" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig="0.972027972027972" /xcortree=641 /SigmaFactorBS="atatactttttacgttaagcagaaagtttttgcaaacttGGG TCGTTtttttaaagcgaagTAGGTCAAAATAAGGAGACAcgatttatcaaaaaagtca a" /listShort="S459, ykaA, pit" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1263609..1263628) /Source="Nicolas_upshift_promotors" /id="U1038" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.677322677322677" /psig="0.987012987012987" /xcortree=1829 /SigmaFactorBS="ggaaccgttttttggtgaaacagaagataaaagttgacagga aaaacacaactTTTGATATACTTTTTACGTTaagcagaaagtttttgcaaacttgggt c" /listShort="S459, ykaA, pit" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1263621) /Source="Nicolas_upshifts" /id="U1038" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.677322677322677" /psig="0.987012987012987" /xcortree=1829 /SigmaFactorBS="ggaaccgttttttggtgaaacagaagataaaagttgacagga aaaacacaactTTTGATATACTTTTTACGTTaagcagaaagtttttgcaaacttgggt c" /listShort="S459, ykaA, pit" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1263703..1265019) /gene="steT" /locus_tag="BSU_12860" /old_locus_tag="BSU12860" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 17344220, 19419962, 20610400" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 17344220, 19419962, 20610400; Product type t : transporter" /codon_start=1 /transl_table=11 /product="serine / threonine exchanger" /protein_id="NP_389169.1" /db_xref="EnsemblGenomes-Gn:BSU12860" /db_xref="EnsemblGenomes-Tr:CAB13143" /db_xref="GOA:O34739" /db_xref="InterPro:IPR002293" /db_xref="SubtiList:BG13227" /db_xref="UniProtKB/Swiss-Prot:O34739" /translation="MHTEDNGLKKEIGLLFALTLVIGTIIGSGVFMKPGAVLAYSGDS KMALFAWLLGGILTLAGGLTIAEIGTQIPKTGGLYTYLEEVYGEFWGFLCGWVQIIIY GPAIIGALGLYFGSLMANLFGWGSGLSKVIGIIAVLFLCVINIIGTKYGGFVQTLTTI GKLIPIACIIVFGLWKGDQHIFTAVNESISDMNFGAAILATLFAYDGWILLAALGGEM KNPEKLLPRAMTGGLLIVTAIYIFINFALLHILSANEIVTLGENATSTAATMLFGSIG GKLISVGIIVSIFGCLNGKVLSFPRVSFAMAERKQLPFAEKLSHVHPSFRTPWIAISF QIALALIMMLISNPDKLSEISIFMIYIFYVMAFFAVFILRKRAKGEKRAYSVPLYPFM PILAIAGSFFVLGSTLITDTMSCGLSILIGLAGLPVYYGMKKRKAS*" /label="steT CDS" gene complement(1263703..1265019) /gene="steT" /locus_tag="BSU_12860" /old_locus_tag="BSU12860" /label="steT gene" downshifts complement(1263718) /Source="Nicolas_upshifts" /id="D700" /incds=0 /nref=3 /ntot=92 /MaxReadThrough="3.59461" /MaxDrop="3.97157" /score="23.3119204" /energy="-14.4" /TU="U1039" /idTUdmin="U1039" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1265066..1265085) /Source="Nicolas_upshift_promotors" /id="U1039" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.633366633366633" /psig="0.992007992007992" /xcortree=2632 /SigmaFactorBS="gtacacaaagcaaatttcgaaaatcagaaaatttattttATT TcacttttctaaaatAGGGTTTACAATATGAAAAAatagattcttcaacatgaagctt c" /listShort="ykbA" /listLong="S459, ykaA, pit" /label="promotor_-10" upshifts complement(1265082) /Source="Nicolas_upshifts" /id="U1039" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.633366633366633" /psig="0.992007992007992" /xcortree=2632 /SigmaFactorBS="gtacacaaagcaaatttcgaaaatcagaaaatttattttATT TcacttttctaaaatAGGGTTTACAATATGAAAAAatagattcttcaacatgaagctt c" /listShort="ykbA" /listLong="S459, ykaA, pit" /label="upshifts" promotor_-35 complement(1265100..1265103) /Source="Nicolas_upshift_promotors" /id="U1039" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.633366633366633" /psig="0.992007992007992" /xcortree=2632 /SigmaFactorBS="gtacacaaagcaaatttcgaaaatcagaaaatttattttATT TcacttttctaaaatAGGGTTTACAATATGAAAAAatagattcttcaacatgaagctt c" /listShort="ykbA" /listLong="S459, ykaA, pit" /label="promotor_-35" promotor_-35 1265302..1265309 /Source="Nicolas_upshift_promotors" /id="U1040" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.774225774225774" /psig="0.964035964035964" /xcortree=632 /SigmaFactorBS="tgaacgaaccttcggtgaagctgataTGTTGACTttctcatg cgaataAAATACTTTGTTATTAGAACaataaatatacaattatgatatgatatctcga a" /listShort="S460, mhqA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1265324..1265343 /Source="Nicolas_upshift_promotors" /id="U1040" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.774225774225774" /psig="0.964035964035964" /xcortree=632 /SigmaFactorBS="tgaacgaaccttcggtgaagctgataTGTTGACTttctcatg cgaataAAATACTTTGTTATTAGAACaataaatatacaattatgatatgatatctcga a" /listShort="S460, mhqA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1265336..1265407 /Source="Nicolas_S_feature" /locus_tag="new_1353008_1353079" /HighExp="Etha, dia15, Salt, Heat, dia5, Diami, H2O2, M9-stat, MG 25, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.964" /TUlongSig="NA" /TUlongPSig="NA" /label="S460" upshifts 1265336 /Source="Nicolas_upshifts" /id="U1040" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.774225774225774" /psig="0.964035964035964" /xcortree=632 /SigmaFactorBS="tgaacgaaccttcggtgaagctgataTGTTGACTttctcatg cgaataAAATACTTTGTTATTAGAACaataaatatacaattatgatatgatatctcga a" /listShort="S460, mhqA" /GFF_Attribute="listLong" /label="upshifts" CDS 1265408..1266358 /gene="mhqA" /locus_tag="BSU_12870" /old_locus_tag="BSU12870" /EC_number="1.13.11.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:17407181, 17725564" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17407181, 17725564; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="hydroquinone-specific extradiol dioxygenase" /protein_id="NP_389170.1" /db_xref="EnsemblGenomes-Gn:BSU12870" /db_xref="EnsemblGenomes-Tr:CAB13144" /db_xref="GOA:O34689" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG13228" /db_xref="UniProtKB/Swiss-Prot:O34689" /translation="MKVNGIHHVSALTADAQKNLDFYKKVLGLKLVKKSVNQDEPTMY HLFYGDEVANPGTELTFFEIPRIAPFHAGTNSISSIGLRVPGTEALHYWKERFEEQQV THSGISKRAGRDILAFQDHEGQRLVLTADEEGKGYGLPVKQSGIPEEFSFRGLGPVEL TVPYAEPTLHVLTNILGFTEISREPVEGQGTAVILESGEGGAATEIHLIERNDLPRER QGKGSVHHVAFRVRDEEELAGWHRIISREGFSNSGIVERYYFKALYFREPNGILFELS TDGPGFMVDENLDELGQTIALPPYLEHRRAEIEAKLKPIQ*" /label="mhqA CDS" gene 1265408..1266358 /gene="mhqA" /locus_tag="BSU_12870" /old_locus_tag="BSU12870" /label="mhqA gene" downshifts 1266346 /Source="Nicolas_upshifts" /id="D701" /incds=0 /nref=95 /ntot=231 /MaxReadThrough="0.70251" /MaxDrop="5.11652" /score="51.2936135" /energy="-17.5" /TU="NA" /idTUdmin="U1040" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS 1266459..1266605 /locus_tag="BSU_12875" /old_locus_tag="BSU12875" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513953.1" /translation="MLIGRNGLKPFANMGDWYGMASAKILSLFINSLFIFACYTISKL DKKE*" /label="hypothetical protein CDS" gene 1266459..1266605 /locus_tag="BSU_12875" /old_locus_tag="BSU12875" /label="gene" CDS 1266613..1268763 /gene="ykcB" /locus_tag="BSU_12880" /old_locus_tag="BSU12880" /EC_number="2.4.1.-" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 18175906; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane glycosyl transferase" /protein_id="NP_389171.2" /db_xref="EnsemblGenomes-Gn:BSU12880" /db_xref="EnsemblGenomes-Tr:CAB13145" /db_xref="GOA:O34575" /db_xref="SubtiList:BG13229" /db_xref="UniProtKB/Swiss-Prot:O34575" /translation="MEKKKRELDIVLLLILLASAFLNIYNIWKDDTVNPYYTAAVTSM MQSFHNFFYASFDAAGFITVDKPPVTYQIQTISALIFGMHGWSVILPQALAGVGSVLL MYLLIKPTFGKTAARIASFVMACTPIAVAVARTNNVDALLVFFLLLATWLLFKAIRKG KLIWLLAAFFVVGVGFNTKMLQAYMILPAFLLFYLIAANATIKKKIVSLVSALAVLAA VSLSWPLIVDNIPASKRPYIGSSQTNSVLELAFGYNGIQRLTGQNSGGGQGAPNKDAS KEMSSSDNTQAPPNQSSSNSSSSDGKSSNGNMAAPPSNGQMPSGGQGGPPSGGDGGQG GPGGDGGKGGTGTGSKMQSGSGMFGTGTPGPLRLFQQELSDQISWLLPFAIFGIAGLL IAGARERRRLSVEQKETVFWVAWLVPIAGFFSVAEFFHHYYLIMLAPPIAALVGAGWV ALVHLYRNQTGWKAWLLPGAIIATTGFELFILRNYNDQIGVGWSIGVGVIGVLSAIAL LLFKQRQKPFSYYVSLAALLALLVMPMYWASTPLLYGGNSSLPETGPQLASMSGKGMG MSDATVNEKLIKYLEENNSGAEYLFATTDSNTAAPYIIKTKKAVMAIGGYSGSDPAIT LTQFKKLVKEGKVKYFLASGMGRGGNNDIVEWVEKNGKEVASEKWQSSSDQKTENTDS ADTSSSKASGENGKMGGPGGMNQSATLYELHADE*" /label="ykcB CDS" gene 1266613..1268763 /gene="ykcB" /locus_tag="BSU_12880" /old_locus_tag="BSU12880" /label="ykcB gene" promotor_no_box 1267502..1267602 /Source="Nicolas_upshift_promotors" /id="U1041" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.608391608391608" /psig="0.000999000999001" /xcortree=1488 /SigmaFactorBS="catcaagcgatggtaaatcctcaaatggcaatatggcggcgc ctccatccaatggccaaatgccaagcggcggtcaaggaggccctccaagcggcggaga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 1267562 /Source="Nicolas_upshifts" /id="U1041" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.608391608391608" /psig="0.000999000999001" /xcortree=1488 /SigmaFactorBS="catcaagcgatggtaaatcctcaaatggcaatatggcggcgc ctccatccaatggccaaatgccaagcggcggtcaaggaggccctccaagcggcggaga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1267650 /Source="Nicolas_upshifts" /id="D702" /incds=1 /nref=4 /ntot=10 /MaxReadThrough="0.56615" /MaxDrop="4.44711" /score="51.2936135" /energy="-17.5" /TU="NA" /idTUdmin="U1041" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 1268775..1269746 /gene="ykcC" /locus_tag="BSU_12890" /old_locus_tag="BSU12890" /EC_number="2.4.-.-" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_389172.2" /db_xref="EnsemblGenomes-Gn:BSU12890" /db_xref="EnsemblGenomes-Tr:CAB13146" /db_xref="GOA:O34319" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG13230" /db_xref="UniProtKB/Swiss-Prot:O34319" /translation="MSRHIQYSIVVPVYNEELVIHETYQRLKEVMDQTKENYELLFVN DGSKDRSIEILREHSLIDPRVKIIDFSRNFGHQIAITAGMDYAQGNAIVVIDADLQDP PELILEMIEKWKEGYEVVYAVRTKRKGETFFKKQTAAMFYRLLSGMTDIDIPIDTGDF RLMDRKVCDEMKRLKEKNPFVRGLVSWVGFKQTAVEYVRDERLAGETKYPLKKMLKLS MDGITTFSHKPLKLASYAGILMSGTGFLYMFIVLYLKLFTDSTITGWSSLIVIQLLFS GIVLLILGVIGEYIGRIYDEAKDRPLYIVQKSYGIENKRLYRDQHMS*" /label="ykcC CDS" gene 1268775..1269746 /gene="ykcC" /locus_tag="BSU_12890" /old_locus_tag="BSU12890" /label="ykcC gene" S_feature complement(1269103..1269744) /Source="Nicolas_S_feature" /locus_tag="new_1356775_1357416_c" /HighExp="T-0.40H, T0.0H, Salt, T0.30H, T-1.10H, C30, T-1.40H, S0, H2O2, T1.0H" /AntisenseName="ykcC" /AntisenseCor="9.6017422892053297E-4" /AntisenseRegPval=0 /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S461" downshifts complement(1269789) /Source="Nicolas_upshifts" /id="D703" /incds=0 /nref=9 /ntot=114 /MaxReadThrough="4.36795" /MaxDrop="4.15844" /score="4.98888048" /energy="-19.1" /TU="U1042" /idTUdmin="U1044" /TUdmin=489 /isTUend="FALSE" /label="downshifts" S_feature complement(1269814..1270180) /Source="Nicolas_S_feature" /locus_tag="new_1357486_1357852_c" /HighExp="T1.0H, T1.30H, T0.30H, T2.0H, T0.0H, T2.30H, T-0.40H, T3.0H, Salt, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99893799999999999" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S462" downshifts complement(1269857) /Source="Nicolas_upshifts" /id="D704" /incds=0 /nref=17 /ntot=157 /MaxReadThrough="6.61192" /MaxDrop="3.74411" /score="4.98888048" /energy="-19.1" /TU="U1042" /idTUdmin="U1044" /TUdmin=421 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1270160..1270175) /Source="Nicolas_upshift_promotors" /id="U1042" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1700 /SigmaFactorBS="agcggtctgaggctttttattagataaaagacctaattgttc taTGAAACTTTCtgacgagatatCCGTATATCATACAGAttgacatcattcacatcag a" /listShort="S462, S461" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1270180) /Source="Nicolas_upshifts" /id="U1042" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1700 /SigmaFactorBS="agcggtctgaggctttttattagataaaagacctaattgttc taTGAAACTTTCtgacgagatatCCGTATATCATACAGAttgacatcattcacatcag a" /listShort="S462, S461" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1270187..1270196) /Source="Nicolas_upshift_promotors" /id="U1042" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1700 /SigmaFactorBS="agcggtctgaggctttttattagataaaagacctaattgttc taTGAAACTTTCtgacgagatatCCGTATATCATACAGAttgacatcattcacatcag a" /listShort="S462, S461" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1270264..1271613) /gene="htrA" /locus_tag="BSU_12900" /old_locus_tag="BSU12900" /EC_number="3.4.21.107" /function="16.6: Maintain" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10692364, 11133960, 11555295, 12823817, 24362423" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10692364, 11133960, 11555295, 12823817, 24362423; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="membrane bound serine protease Do, quality control protease and chaperone (heat-shock protein)" /protein_id="NP_389173.2" /db_xref="EnsemblGenomes-Gn:BSU12900" /db_xref="EnsemblGenomes-Tr:CAB13147" /db_xref="GOA:O34358" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR001940" /db_xref="InterPro:IPR009003" /db_xref="InterPro:IPR036034" /db_xref="SubtiList:BG12608" /db_xref="UniProtKB/Swiss-Prot:O34358" /translation="MDNYRDENRTKGNENEVFLTKENDQSASYSARNVIHDQEKKKRG FGWFRPLLGGVIGGSLALGIYTFTPLGDHDSQDTAKQSSSQQQTQSVTATSTSSESKK SSSSSSAFKSEDSSKISDMVEDLSPAIVGITNLQAQSNSSLFGSSSSDSSEDTESGSG SGVIFKKENGKAYIITNNHVVEGASSLKVSLYDGTEVTAKLVGSDSLTDLAVLQISDD HVTKVANFGDSSDLRTGETVIAIGDPLGKDLSRTVTQGIVSGVDRTVSMSTSAGETSI NVIQTDAAINPGNSGGPLLNTDGKIVGINSMKISEDDVEGIGFAIPSNDVKPIAEELL SKGQIERPYIGVSMLDLEQVPQNYQEGTLGLFGSQLNKGVYIREVASGSPAEKAGLKA EDIIIGLKGKEIDTGSELRNILYKDAKIGDTVEVKILRNGKEMTKKIKLDQKEEKTS* " /label="htrA CDS" gene complement(1270264..1271613) /gene="htrA" /locus_tag="BSU_12900" /old_locus_tag="BSU12900" /label="htrA gene" downshifts complement(1270278) /Source="Nicolas_upshifts" /id="D705" /incds=0 /nref=198 /ntot=244 /MaxReadThrough="2.95586" /MaxDrop="5.35972" /score="30.7234179" /energy="-19.9" /TU="NA" /idTUdmin="U1044" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1271653..1271660 /Source="Nicolas_upshift_promotors" /id="U1043" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.948051948051948" /psig="0.999000999001" /xcortree=2991 /SigmaFactorBS="tcatgttcactccgtttctctattttcacatgtctatttaTA TTGATAggtttatgacttgaGTTTATCATAAACAAAAACTgtgggataaaaatgaaaa g" /GFF_Attribute="listShort" /listLong="proG" /label="promotor_-35" promotor_-10 complement(1271665..1271684) /Source="Nicolas_upshift_promotors" /id="U1044" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.865134865134865" /psig="0.998001998001998" /xcortree=1763 /SigmaFactorBS="tttccgcactttttcacaatttcccataatcttttcattttT ATCCCACagtttttgttTATGATAAACTCAAGTCATAaacctatcaatataaatagac a" /listShort="htrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1271673 /Source="Nicolas_upshifts" /id="U1043" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.948051948051948" /psig="0.999000999001" /xcortree=2991 /SigmaFactorBS="tcatgttcactccgtttctctattttcacatgtctatttaTA TTGATAggtttatgacttgaGTTTATCATAAACAAAAACTgtgggataaaaatgaaaa g" /GFF_Attribute="listShort" /listLong="proG" /label="upshifts" promotor_-10 1271675..1271694 /Source="Nicolas_upshift_promotors" /id="U1043" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.948051948051948" /psig="0.999000999001" /xcortree=2991 /SigmaFactorBS="tcatgttcactccgtttctctattttcacatgtctatttaTA TTGATAggtttatgacttgaGTTTATCATAAACAAAAACTgtgggataaaaatgaaaa g" /GFF_Attribute="listShort" /listLong="proG" /label="promotor_-10" upshifts complement(1271683) /Source="Nicolas_upshifts" /id="U1044" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.865134865134865" /psig="0.998001998001998" /xcortree=1763 /SigmaFactorBS="tttccgcactttttcacaatttcccataatcttttcattttT ATCCCACagtttttgttTATGATAAACTCAAGTCATAaacctatcaatataaatagac a" /listShort="htrA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1271685..1271767) /Source="Nicolas_S_feature" /locus_tag="new_1359357_1359439_c" /HighExp="Etha, dia5, S8, S6, T2.0H, T3.30H, dia15, T5.0H, BC, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.682" /TUlongSig="NA" /TUlongPSig="NA" /label="S463" promotor_-35 complement(1271695..1271702) /Source="Nicolas_upshift_promotors" /id="U1044" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.865134865134865" /psig="0.998001998001998" /xcortree=1763 /SigmaFactorBS="tttccgcactttttcacaatttcccataatcttttcattttT ATCCCACagtttttgttTATGATAAACTCAAGTCATAaacctatcaatataaatagac a" /listShort="htrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1271724..1271730 /Source="Nicolas_upshift_promotors" /id="U1045" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.390609390609391" /psig="0.994005994005994" /xcortree=2259 /SigmaFactorBS="aaaaactgtgggataaaaatgaaaagattatgggaaATTGTG AaaaagtgcggaaaaCGGTACACTTCATATTGTATatgaaaggactgagtcgatggaa c" /listShort="proG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1271745..1271764 /Source="Nicolas_upshift_promotors" /id="U1045" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.390609390609391" /psig="0.994005994005994" /xcortree=2259 /SigmaFactorBS="aaaaactgtgggataaaaatgaaaagattatgggaaATTGTG AaaaagtgcggaaaaCGGTACACTTCATATTGTATatgaaaggactgagtcgatggaa c" /listShort="proG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1271748 /Source="Nicolas_upshifts" /id="U1045" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.390609390609391" /psig="0.994005994005994" /xcortree=2259 /SigmaFactorBS="aaaaactgtgggataaaaatgaaaagattatgggaaATTGTG AaaaagtgcggaaaaCGGTACACTTCATATTGTATatgaaaggactgagtcgatggaa c" /listShort="proG" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1271750..1271769) /Source="Nicolas_upshift_promotors" /id="U1046" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.416583416583417" /psig="0.682317682317682" /xcortree=624 /SigmaFactorBS="tcatatccgccatgctgccatatccaatcaatccaatctGTT CcatcgactcagtcctTTCATATACAATATGAAGTGtaccgttttccgcactttttca c" /listShort="S463, htrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1271767) /Source="Nicolas_upshifts" /id="U1046" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.416583416583417" /psig="0.682317682317682" /xcortree=624 /SigmaFactorBS="tcatatccgccatgctgccatatccaatcaatccaatctGTT CcatcgactcagtcctTTCATATACAATATGAAGTGtaccgttttccgcactttttca c" /listShort="S463, htrA" /GFF_Attribute="listLong" /label="upshifts" CDS 1271782..1272600 /gene="proCC" /locus_tag="BSU_12910" /old_locus_tag="BSU12910" /EC_number="1.5.1.2" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11418582" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418582; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="redundant pyrroline-5-carboxylate reductase" /protein_id="NP_389174.1" /db_xref="EnsemblGenomes-Gn:BSU12910" /db_xref="EnsemblGenomes-Tr:CAB13148" /db_xref="GOA:Q00777" /db_xref="InterPro:IPR000304" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR028939" /db_xref="InterPro:IPR029036" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10841" /db_xref="UniProtKB/Swiss-Prot:Q00777" /translation="MEQIGLIGYGSMADMIARQLLKHEQIKENELFIETRTKGERLRA LMSDYPNVSADPLENWANTCQLILICVPPLHVIETMRRLYPYVNRNTHIVSIAAGVPL RLLEAETEAGISRVIPAITSEAEAGISLVVHSEALAAEKKERLNELLSVFSRVREIKE SNLDVASNLTSSAPGFIAAIFEELALSAVRNSSLSKEEAFDFLIHSLYGTGKMLIEKN MSFEETLERVATKGGITGEGAEVIHASVPDVFDEVFERTLRKYELLTEQVGKQT*" /label="proCC CDS" gene 1271782..1272600 /gene="proCC" /locus_tag="BSU_12910" /old_locus_tag="BSU12910" /label="proCC gene" promotor_-35 complement(1271785..1271788) /Source="Nicolas_upshift_promotors" /id="U1046" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.416583416583417" /psig="0.682317682317682" /xcortree=624 /SigmaFactorBS="tcatatccgccatgctgccatatccaatcaatccaatctGTT CcatcgactcagtcctTTCATATACAATATGAAGTGtaccgttttccgcactttttca c" /listShort="S463, htrA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1272578 /Source="Nicolas_upshifts" /id="D706" /incds=0 /nref=90 /ntot=220 /MaxReadThrough="1.3818" /MaxDrop="4.43155" /score="-5.08770006" /energy="-5.3" /TU="NA" /idTUdmin="U1045" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1272657..1272664 /Source="Nicolas_upshift_promotors" /id="U1047" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2874 /SigmaFactorBS="tttatcactgaatgattgagatttttcccagttaTATTGCAT ttttcctcttttttTAATATAATTTGTTAGAATAttcataatttagtaaaaaaggagg a" /listShort="dppA, dppB, dppC, dppD, dppE, ykfA, ykfB, ykfC, ykfD, S465" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1272679..1272698 /Source="Nicolas_upshift_promotors" /id="U1047" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2874 /SigmaFactorBS="tttatcactgaatgattgagatttttcccagttaTATTGCAT ttttcctcttttttTAATATAATTTGTTAGAATAttcataatttagtaaaaaaggagg a" /listShort="dppA, dppB, dppC, dppD, dppE, ykfA, ykfB, ykfC, ykfD, S465" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1272683 /Source="Nicolas_upshifts" /id="U1047" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2874 /SigmaFactorBS="tttatcactgaatgattgagatttttcccagttaTATTGCAT ttttcctcttttttTAATATAATTTGTTAGAATAttcataatttagtaaaaaaggagg a" /listShort="dppA, dppB, dppC, dppD, dppE, ykfA, ykfB, ykfC, ykfD, S465" /GFF_Attribute="listLong" /label="upshifts" CDS 1272729..1273553 /gene="dppA" /locus_tag="BSU_12920" /old_locus_tag="BSU12920" /EC_number="3.4.11.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11069674, 11473256, 19340926" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11069674, 11473256, 19340926; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanyl-aminopeptidase" /protein_id="NP_389175.2" /db_xref="EnsemblGenomes-Gn:BSU12920" /db_xref="EnsemblGenomes-Tr:CAB13149" /db_xref="GOA:P26902" /db_xref="InterPro:IPR007035" /db_xref="InterPro:IPR027476" /db_xref="InterPro:IPR033824" /db_xref="InterPro:IPR036177" /db_xref="PDB:1HI9" /db_xref="SubtiList:BG10842" /db_xref="UniProtKB/Swiss-Prot:P26902" /translation="MKLYMSVDMEGISGLPDDTFVDSGKRNYERGRLIMTEEANYCIA EAFNSGCTEVLVNDSHSKMNNLMVEKLHPEADLISGDVKPFSMVEGLDDTFRGALFLG YHARASTPGVMSHSMIFGVRHFYINDRPVGELGLNAYVAGYYDVPVLMVAGDDRAAKE AEELIPNVTTAAVKQTISRSAVKCLSPAKAGRLLTEKTAFALQNKDKVKPLTPPDRPV LSIEFANYGQAEWANLMPGTEIKTGTTTVQFQAKDMLEAYQAMLVMTELAMRTSFC*" /label="dppA CDS" gene 1272729..1273553 /gene="dppA" /locus_tag="BSU_12920" /old_locus_tag="BSU12920" /label="dppA gene" CDS 1273570..1274496 /gene="dppB" /locus_tag="BSU_12930" /old_locus_tag="BSU12930" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1766370, 7536291, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766370, 7536291, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="dipeptide ABC transporter (permease)" /protein_id="NP_389176.1" /db_xref="EnsemblGenomes-Gn:BSU12930" /db_xref="EnsemblGenomes-Tr:CAB13150" /db_xref="GOA:P26903" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG10843" /db_xref="UniProtKB/Swiss-Prot:P26903" /translation="MARYMIKRFWAMAATILVITTLTFVLMKVIPGSPFNEERGTNEA VQKNLEAYYHLDDPLIFQYIFYLKSIITFDFGPSIKKPSDSVNDMLERGFPVSFELGM TAIVIAVISGLVLGVIAALRRNGFLDYAAMSLAVLGISIPNFILATLLIQQFAVNLKL FPAATWTSPIHMVLPTAALAVGPMAIIARLTRSSMVEVLTQDYIRTAKAKGLSPFKII VKHALRNALMPVITVLGTLVASILTGSFVIEKIFAIPGMGKYFVESINQRDYPVIMGT TVFYSVILIIMLFLVDLAYGLLDPRIKLHKKG*" /label="dppB CDS" gene 1273570..1274496 /gene="dppB" /locus_tag="BSU_12930" /old_locus_tag="BSU12930" /label="dppB gene" CDS 1274502..1275464 /gene="dppC" /locus_tag="BSU_12940" /old_locus_tag="BSU12940" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1766370, 7536291, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766370, 7536291, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="dipeptide ABC transporter (permease)" /protein_id="NP_389177.1" /db_xref="EnsemblGenomes-Gn:BSU12940" /db_xref="EnsemblGenomes-Tr:CAB13151" /db_xref="GOA:P26904" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR025966" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG10844" /db_xref="UniProtKB/Swiss-Prot:P26904" /translation="MNLPVQTDERQPEQHNQVPDEWFVLNQEKNREADSVKRPSLSYT QDAWRRLKKNKLAMAGLFILLFLFVMAVIGPFLSPHSVVRQSLTEQNLPPSADHWFGT DELGRDVFTRTWYGARISLFVGVMAALIDFLIGVIYGGVAGYKGGRIDSIMMRIIEVL YGLPYLLVVILLMVLMGPGLGTIIVALTVTGWVGMARIVRGQVLQIKNYEYVLASKTF GAKTFRIIRKNLLPNTMGAIIVQMTLTVPAAIFAESFLSFLGLGIQAPFASWGVMAND GLPTILSGHWWRLFFPAFFISLTMYAFNVLGDGLQDALDPKLRR*" /label="dppC CDS" gene 1274502..1275464 /gene="dppC" /locus_tag="BSU_12940" /old_locus_tag="BSU12940" /label="dppC gene" promotor_-35 1275196..1275201 /Source="Nicolas_upshift_promotors" /id="U1048" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=761 /SigmaFactorBS="cgcgaaaacctttcgcatcatccggaagaatttgctgcCGAA TActatgggagcgatcaTCGTACAAATGACATTAACcgtacctgccgccatattcgca g" /listShort="dppD, dppE, ykfA, ykfB, ykfC, ykfD, S465" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1275217..1275235 /Source="Nicolas_upshift_promotors" /id="U1048" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=761 /SigmaFactorBS="cgcgaaaacctttcgcatcatccggaagaatttgctgcCGAA TActatgggagcgatcaTCGTACAAATGACATTAACcgtacctgccgccatattcgca g" /listShort="dppD, dppE, ykfA, ykfB, ykfC, ykfD, S465" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1275218 /Source="Nicolas_upshifts" /id="U1048" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=761 /SigmaFactorBS="cgcgaaaacctttcgcatcatccggaagaatttgctgcCGAA TActatgggagcgatcaTCGTACAAATGACATTAACcgtacctgccgccatattcgca g" /listShort="dppD, dppE, ykfA, ykfB, ykfC, ykfD, S465" /GFF_Attribute="listLong" /label="upshifts" CDS 1275469..1276476 /gene="dppD" /locus_tag="BSU_12950" /old_locus_tag="BSU12950" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7536291" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7536291; Product type t : transporter" /codon_start=1 /transl_table=11 /product="dipeptide ABC transporter (ATP-binding subunit)" /protein_id="NP_389178.1" /db_xref="EnsemblGenomes-Gn:BSU12950" /db_xref="EnsemblGenomes-Tr:CAB13152" /db_xref="GOA:P26905" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013563" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10845" /db_xref="UniProtKB/Swiss-Prot:P26905" /translation="MEKVLSVQNLHVSFTTYGGTVQAVRGVSFDLYKGETFAIVGESG CGKSVTSQSIMGLLPPYSAKVTDGRILFKNKDLCRLSDKEMRGIRGADISMIFQDPMT ALNPTLTVGDQLGEALLRHKKMSKKAARKEVLSMLSLVGIPDPGERLKQYPHQFSGGM RQRIVIAMALICEPDILIADEPTTALDVTIQAQILELFKEIQRKTDVSVILITHDLGV VAQVADRVAVMYAGKMAEIGTRKDIFYQPQHPYTKGLLGSVPRLDLNGAELTPIDGTP PDLFSPPPGCPFAARCPNRMVVCDRVYPGQTIRSDSHTVNCWLQDQRAEHAVLSGDAK D*" /label="dppD CDS" gene 1275469..1276476 /gene="dppD" /locus_tag="BSU_12950" /old_locus_tag="BSU12950" /label="dppD gene" CDS 1276479..1278128 /gene="dppE" /locus_tag="BSU_12960" /old_locus_tag="BSU12960" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7783641, 8793880, 11390694" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7783641, 8793880, 11390694; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="dipeptide ABC transporter (dipeptide-binding lipoprotein)" /protein_id="NP_389179.2" /db_xref="EnsemblGenomes-Gn:BSU12960" /db_xref="EnsemblGenomes-Tr:CAB13153" /db_xref="GOA:P26906" /db_xref="InterPro:IPR000914" /db_xref="InterPro:IPR023765" /db_xref="InterPro:IPR030678" /db_xref="SubtiList:BG10846" /db_xref="UniProtKB/Swiss-Prot:P26906" /translation="MKRGKRMKRVKKLWGMGLALGLSFALMGCTANEQAGKEGSHDKA KTSGEKVLYVNNENEPTSFDPPIGFNNVSWQPLNNIMEGLTRLGKDHEPEPAMAEKWS VSKDNKTYTFTIRENAKWTNGDPVTAGDFEYAWKRMLDPKKGASSAFLGYFIEGGEAY NSGKGKKDDVKVTAKDDRTLEVTLEAPQKYFLSVVSNPAYFPVNEKVDKDNPKWFAES DTFVGNGPFKLTEWKHDDSITMEKSDTYWDKDTVKLDKVKWAMVSDRNTDYQMFQSGE LDTAYVPAELSDQLLDQDNVNIVDQAGLYFYRFNVNMEPFQNENIRKAFAMAVDQEEI VKYVTKNNEKPAHAFVSPGFTQPDGKDFREAGGDLIKPNESKAKQLLEKGMKEENYNK LPAITLTYSTKPEHKKIAEAIQQKLKNSLGVDVKLANMEWNVFLEDQKALKFQFSQSS FLPDYADPISFLEAFQTGNSMNRTGWANKEYDQLIKQAKNEADEKTRFSLMHQAEELL INEAPIIPVYFYNQVHLQNEQVKGIVRHPVGYIDLKWADKN*" /label="dppE CDS" gene 1276479..1278128 /gene="dppE" /locus_tag="BSU_12960" /old_locus_tag="BSU12960" /label="dppE gene" downshifts 1278122 /Source="Nicolas_upshifts" /id="D707" /incds=0 /nref=2 /ntot=25 /MaxReadThrough="6.73127" /MaxDrop="3.5888" /score="22.838155" /energy="-13.9" /TU="U1047,U1048" /idTUdmin="U1048" /TUdmin="-4469" /isTUend="FALSE" /label="downshifts" CDS 1278216..1279175 /gene="ldcA" /locus_tag="BSU_12970" /old_locus_tag="BSU12970" /EC_number="3.4.17.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10428950, 15101989, 18535144, 20944232, 24123814; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="muropeptide L,D-carboxypeptidase" /protein_id="NP_389180.2" /db_xref="EnsemblGenomes-Gn:BSU12970" /db_xref="EnsemblGenomes-Tr:CAB13154" /db_xref="GOA:O34851" /db_xref="InterPro:IPR003507" /db_xref="InterPro:IPR027461" /db_xref="InterPro:IPR027478" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG13231" /db_xref="UniProtKB/Swiss-Prot:O34851" /translation="MKGVFSLNYKPKALNKGDTVGVIAPASPPDPKKLDTALLFLEEL GLQVKLGKALKNQHGYLAGQDDERLADLHEMFRDDEVKAVLCACGGFGTGRIAAGIDF SLIRKHPKIFWGYSDITFLHTAIHQNTGLVTFHGPMLSTDIGLDDVHPLTKASYKQLF QETEFTYTEELSPLTELVPGKAEGELVGGNLSLLTSTLGTPFEIDTRGKLLFIEDIDE EPYQIDRMLNQLKMGGKLTDAAGILVCDFHNCVPVKREKSLSLEQVLEDYIISAGRPA LRGFKIGHCSPSIAVPIGAKAAMNTAEKTAVIEAGVSEGALKT*" /label="ldcA CDS" gene 1278216..1279175 /gene="ldcA" /locus_tag="BSU_12970" /old_locus_tag="BSU12970" /label="ldcA gene" CDS 1279172..1280272 /gene="aeeB" /locus_tag="BSU_12980" /old_locus_tag="BSU12980" /EC_number="5.1.1.20" /function="16.11: Scavenge (Catabolism)" /function="16.5: Explore" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11747447, 11747448, 15101989" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11747447, 11747448, 15101989; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-Ala-D/L-Glu epimerase" /protein_id="NP_389181.1" /db_xref="EnsemblGenomes-Gn:BSU12980" /db_xref="EnsemblGenomes-Tr:CAB13155" /db_xref="GOA:O34508" /db_xref="InterPro:IPR013341" /db_xref="InterPro:IPR013342" /db_xref="InterPro:IPR029017" /db_xref="InterPro:IPR029065" /db_xref="InterPro:IPR034390" /db_xref="InterPro:IPR036849" /db_xref="PDB:1JPM" /db_xref="PDB:1TKK" /db_xref="SubtiList:BG13232" /db_xref="UniProtKB/Swiss-Prot:O34508" /translation="MKIIRIETSRIAVPLTKPFKTALRTVYTAESVIVRITYDSGAVG WGEAPPTLVITGDSMDSIESAIHHVLKPALLGKSLAGYEAILHDIQHLLTGNMSAKAA VEMALYDGWAQMCGLPLYQMLGGYRDTLETDYTVSVNSPEEMAADAENYLKQGFQTLK IKVGKDDIATDIARIQEIRKRVGSAVKLRLDANQGWRPKEAVTAIRKMEDAGLGIELV EQPVHKDDLAGLKKVTDATDTPIMADESVFTPRQAFEVLQTRSADLINIKLMKAGGIS GAEKINAMAEACGVECMVGSMIETKLGITAAAHFAASKRNITRFDFDAPLMLKTDVFN GGITYSGSTISMPGKPGLGIIGAALLKGEKEQ*" /label="aeeB CDS" gene 1279172..1280272 /gene="aeeB" /locus_tag="BSU_12980" /old_locus_tag="BSU12980" /label="aeeB gene" CDS 1280269..1281159 /gene="eepC" /locus_tag="BSU_12990" /old_locus_tag="BSU12990" /EC_number="3.4.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15101989, 20944232" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15101989, 20944232; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="gamma-D-glutamyl-L-diaminoacid endopeptidase" /protein_id="NP_389182.2" /db_xref="EnsemblGenomes-Gn:BSU12990" /db_xref="EnsemblGenomes-Tr:CAB13156" /db_xref="GOA:O35010" /db_xref="InterPro:IPR000064" /db_xref="SubtiList:BG13233" /db_xref="UniProtKB/Swiss-Prot:O35010" /translation="MMHTVISAVANIWTAPDSPRPSDQFMLQPTVMIRDWLERMTYDE RLGLCTDNVIQTQVLFGEKVLVTAEQGEWVSVIVPSQPSRKDPRGYPGWMKKYQLEKT KPIHTQHDVMISKPAAFLYRSNGEKEIELSFLTVLPLIAKENGYFKVSTVFGERFVRQ SDAVPVSQQKGTAEDIIQTGAFFLGLPYLWGGISGFGFDCSGFMYSIFKANGYSIPRD AGDQAKAGKGVPLDDMKAGDLLFFAYEEGKGAIHHVGLYVGGGKMLHSPKTGKSIEIL TLTETIYEKELCAVRRCFSE*" /label="eepC CDS" gene 1280269..1281159 /gene="eepC" /locus_tag="BSU_12990" /old_locus_tag="BSU12990" /label="eepC gene" CDS 1281172..1282161 /gene="ykfD" /locus_tag="BSU_13000" /old_locus_tag="BSU13000" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15101989; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative cell wall oligopeptide ABC transporter (ATP binding protein)" /protein_id="NP_389183.2" /db_xref="EnsemblGenomes-Gn:BSU13000" /db_xref="EnsemblGenomes-Tr:CAB13157" /db_xref="GOA:C0SP98" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013563" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13234" /db_xref="UniProtKB/Swiss-Prot:C0SP98" /translation="MRRLPLLEVSQLKMHFDAGKKRTVKAVDGVTFQIREGETFGLVG ESGCGKSTLGRVLMRLYQPTEGSVTYRGTNLHALSEKEQFAFNRKLQMIFQDPYASLN PRMTVREIILEPMEIHNLYNTHKARLLVVDELLEAVGLHPDFGSRYPHEFSGGQRQRI GIARALSLNPEFIVADEPISALDVSVQAQVVNLLKRLQKEKGLTFLFIAHDLSMVKHI SDRIGVMYLGHMMEITESGTLYREPLHPYTKALLSSIPIPDPELEDKRERILLKGELP SPVNPPSGCVFRTRCPEAMPECGESRPQLQEIEPGRFVACHLYRNAETKEKVR*" /label="ykfD CDS" gene 1281172..1282161 /gene="ykfD" /locus_tag="BSU_13000" /old_locus_tag="BSU13000" /label="ykfD gene" S_feature complement(1281455..1282182) /Source="Nicolas_S_feature" /locus_tag="new_1369127_1369854_c" /HighExp="Etha, S7, Gly, M40t90, C30, H2O2, M0t90, dia15, T1.0H, S8" /AntisenseName="ykfD" /AntisenseCor="-6.3474114158352593E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S464" downshifts 1282151 /Source="Nicolas_upshifts" /id="D708" /incds=0 /nref=1 /ntot=91 /MaxReadThrough="5.08319" /MaxDrop="3.1399" /score="-3.10371155" /energy="-13.9" /TU="U1047,U1048" /idTUdmin="U1048" /TUdmin="-440" /isTUend="FALSE" /label="downshifts" S_feature 1282196..1283364 /Source="Nicolas_S_feature" /locus_tag="new_1369868_1371036" /HighExp="T3.30H, T4.0H, T3.0H, T5.0H, T2.30H, T2.0H, S1, M9-stat, T1.30H, HiOs" /AntisenseName="ykgB" /AntisenseCor="-0.33524952291190102" /AntisenseRegPval="-7.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S465" CDS complement(1282204..1283253) /gene="pgl" /locus_tag="BSU_13010" /old_locus_tag="BSU13010" /EC_number="3.1.1.31" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:22960854, 28032445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22960854, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="6-phosphogluconolactonase" /protein_id="NP_389184.1" /db_xref="EnsemblGenomes-Gn:BSU13010" /db_xref="EnsemblGenomes-Tr:CAB13158" /db_xref="GOA:O34499" /db_xref="InterPro:IPR011048" /db_xref="InterPro:IPR015943" /db_xref="InterPro:IPR019405" /db_xref="SubtiList:BG13236" /db_xref="UniProtKB/Swiss-Prot:O34499" /translation="MTKYIGYVGTYTKGGSEGIYSFELDTEKKALSEPKLAAKLGNPT YVATNKNNTILYSIEKADGQGGVAAYQIDKNSGELTFLNHQLIDGPSPCHVSVDDQNQ FVLTANYHSGKVHVFPVQEDGSLQSPVSEAAHTGKGPHERQEKPHTHYAGFTPEHNYV VAVDLGIDKLYTYKLKDGVLTESGSHSFAPGAGPRHIAFHPKEKYAYVMTELSNEVIA LEYNPTAGEFREIQVVSAIPDDFTDNSQGSAIHVTQDGRFVYVANRGHDSIAVFEVNQ YSGELAFVERVSTEGNWPRDFVFDPTEGFLVASNEETGNLVLFERDKETGRLTLLPST VSVPYPVCVKFLHQV*" /label="pgl CDS" gene complement(1282204..1283253) /gene="pgl" /locus_tag="BSU_13010" /old_locus_tag="BSU13010" /label="pgl gene" downshifts complement(1282227) /Source="Nicolas_upshifts" /id="D709" /incds=0 /nref=208 /ntot=262 /MaxReadThrough="5.12776" /MaxDrop="6.0668" /score="24.6986564" /energy="-15.6" /TU="U1050" /idTUdmin="U1049" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1283280..1283299) /Source="Nicolas_upshift_promotors" /id="U1049" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=2235 /SigmaFactorBS="ggcgaatgaagaatcttcccctttttcatgTTTTGAACagct tattttatcaAGATACGTTAATATAGAGGTgacatcatttttaagggggaaatcgcat g" /listShort="ykgB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1283291) /Source="Nicolas_upshifts" /id="U1049" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=2235 /SigmaFactorBS="ggcgaatgaagaatcttcccctttttcatgTTTTGAACagct tattttatcaAGATACGTTAATATAGAGGTgacatcatttttaagggggaaatcgcat g" /listShort="ykgB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1283314..1283321) /Source="Nicolas_upshift_promotors" /id="U1049" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=2235 /SigmaFactorBS="ggcgaatgaagaatcttcccctttttcatgTTTTGAACagct tattttatcaAGATACGTTAATATAGAGGTgacatcatttttaagggggaaatcgcat g" /listShort="ykgB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1283343..1284203) /gene="ddaH" /locus_tag="BSU_13020" /old_locus_tag="BSU13020" /EC_number="3.5.3.18" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 27258038; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="N(G),N(G)-dimethylarginine dimethylaminohydrolase" /protein_id="NP_389185.2" /db_xref="EnsemblGenomes-Gn:BSU13020" /db_xref="EnsemblGenomes-Tr:CAB13159" /db_xref="GOA:O34497" /db_xref="InterPro:IPR033199" /db_xref="SubtiList:BG13235" /db_xref="UniProtKB/Swiss-Prot:O34497" /translation="MDVSIPKSQHKTVCRTEYGTLQKVILCKPEHMTIKDVINETQKH FEDDNIHVKTANDQHSRLVEALRSHNVEVVLLPVRDGLPEQVFTRDIGFVIGEKAFLS SMTEPIRQGEEAVIKDFFHSQGISYTRMLDTSIEGGDVIIDDDIVYVGISQRTDISAI GQLEEALPEYTIVPVKLHEKFLHLDCVFNIISESEALIYSQAIEPDAADMLAKRYDLI EVPEDEQFTLGTNVLSIGKKTIISLPGNRHVNQQLSKRGYHIIEIDLSEIIKSGGSFR CCTMPLIRGE*" /label="ddaH CDS" gene complement(1283343..1284203) /gene="ddaH" /locus_tag="BSU_13020" /old_locus_tag="BSU13020" /label="ddaH gene" promotor_-10 complement(1284228..1284246) /Source="Nicolas_upshift_promotors" /id="U1050" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=242 /SigmaFactorBS="aaacaatattctcttccatttgtctaaaatttaaaatGGTTT AAtgattttcatgatgaGGGAATAATAAATGTATTCttcacactttaggaggaaaaac a" /listShort="ykgA, ykgB, S464" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1284245) /Source="Nicolas_upshifts" /id="U1050" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=242 /SigmaFactorBS="aaacaatattctcttccatttgtctaaaatttaaaatGGTTT AAtgattttcatgatgaGGGAATAATAAATGTATTCttcacactttaggaggaaaaac a" /listShort="ykgA, ykgB, S464" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1284262..1284268) /Source="Nicolas_upshift_promotors" /id="U1050" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=242 /SigmaFactorBS="aaacaatattctcttccatttgtctaaaatttaaaatGGTTT AAtgattttcatgatgaGGGAATAATAAATGTATTCttcacactttaggaggaaaaac a" /listShort="ykgA, ykgB, S464" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1284277..1284284 /Source="Nicolas_upshift_promotors" /id="U1051" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.933066933066933" /psig=1 /xcortree=2004 /SigmaFactorBS="cctcatcatgaaaatcattaaaccattttaaaTTTTAGACaa atggaagagaaTATTGTTTAATAGGAGAATAtaagtgcatttagctaaaagatcagac a" /listShort="ykhA, S466, hmp" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1284298..1284317 /Source="Nicolas_upshift_promotors" /id="U1051" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.933066933066933" /psig=1 /xcortree=2004 /SigmaFactorBS="cctcatcatgaaaatcattaaaccattttaaaTTTTAGACaa atggaagagaaTATTGTTTAATAGGAGAATAtaagtgcatttagctaaaagatcagac a" /listShort="ykhA, S466, hmp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1284305 /Source="Nicolas_upshifts" /id="U1051" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.933066933066933" /psig=1 /xcortree=2004 /SigmaFactorBS="cctcatcatgaaaatcattaaaccattttaaaTTTTAGACaa atggaagagaaTATTGTTTAATAGGAGAATAtaagtgcatttagctaaaagatcagac a" /listShort="ykhA, S466, hmp" /GFF_Attribute="listLong" /label="upshifts" CDS 1284363..1284881 /gene="ykhA" /locus_tag="BSU_13030" /old_locus_tag="BSU13030" /EC_number="3.1.2.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12426338, 18247525, 24623648, 24722906; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous acyl-CoA thioesterase" /protein_id="NP_389186.2" /db_xref="EnsemblGenomes-Gn:BSU13030" /db_xref="EnsemblGenomes-Tr:CAB13160" /db_xref="GOA:P49851" /db_xref="InterPro:IPR006683" /db_xref="InterPro:IPR029069" /db_xref="InterPro:IPR033120" /db_xref="SubtiList:BG11417" /db_xref="UniProtKB/Swiss-Prot:P49851" /translation="METPETRFCKESKVVKTSRVFPLDTNNHNTLFGGKLMSYIDDIA SISAARHCRRETVTASMDSVDFLKPIGQKDSVCLESYVTWVGTSSMEVFVKVIKEHLM TGERELAATSFLTFVALDSNGKPVPVPRVVPETEEEIMLHNTAVQRANERKNRKRHSQ ALANALGTDKPW*" /label="ykhA CDS" gene 1284363..1284881 /gene="ykhA" /locus_tag="BSU_13030" /old_locus_tag="BSU13030" /label="ykhA gene" downshifts 1284872 /Source="Nicolas_upshifts" /id="D710" /incds=0 /nref=34 /ntot=265 /MaxReadThrough="4.66856" /MaxDrop="4.77681" /score="24.0889455" /energy="-10.9" /TU="U1051" /idTUdmin="U1051" /TUdmin="-1436" /isTUend="FALSE" /label="downshifts" promotor_-35 1284946..1284952 /Source="Nicolas_upshift_promotors" /id="U1052" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=854 /SigmaFactorBS="tgttttgggtttttttgtacttttcaatggtgattattacaa TGGTTAGtccgtttttgctaGGGGATTCTATAaaaaagcaacaaatgtcatgttaaat t" /listShort="S466, hmp" /listLong="S467, ykjA, ykkA" /label="promotor_-35" S_feature 1284964..1285070 /Source="Nicolas_S_feature" /locus_tag="new_1372636_1372742" /HighExp="Etha, S5, S6, S8, nit, S7, ferm, S4, dia15, dia5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigA" /TUshortPSig="0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S466" upshifts 1284964 /Source="Nicolas_upshifts" /id="U1052" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=854 /SigmaFactorBS="tgttttgggtttttttgtacttttcaatggtgattattacaa TGGTTAGtccgtttttgctaGGGGATTCTATAaaaaagcaacaaatgtcatgttaaat t" /listShort="S466, hmp" /listLong="S467, ykjA, ykkA" /label="upshifts" promotor_-10 1284966..1284977 /Source="Nicolas_upshift_promotors" /id="U1052" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=854 /SigmaFactorBS="tgttttgggtttttttgtacttttcaatggtgattattacaa TGGTTAGtccgtttttgctaGGGGATTCTATAaaaaagcaacaaatgtcatgttaaat t" /listShort="S466, hmp" /listLong="S467, ykjA, ykkA" /label="promotor_-10" promotor_-35 1285045..1285048 /Source="Nicolas_upshift_promotors" /id="U1053" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.452547452547453" /psig="0.99000999000999" /xcortree=1618 /SigmaFactorBS="ttgtgacaactttattaaagattcattttagatATATctttt attcgtaagaTCATGTATTTTAAAGATATAttttaaatacatcttttcgaaaggattg t" /listShort="hmp, S467, ykjA, ykkA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1285064..1285083 /Source="Nicolas_upshift_promotors" /id="U1053" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.452547452547453" /psig="0.99000999000999" /xcortree=1618 /SigmaFactorBS="ttgtgacaactttattaaagattcattttagatATATctttt attcgtaagaTCATGTATTTTAAAGATATAttttaaatacatcttttcgaaaggattg t" /listShort="hmp, S467, ykjA, ykkA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1285072 /Source="Nicolas_upshifts" /id="U1053" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.452547452547453" /psig="0.99000999000999" /xcortree=1618 /SigmaFactorBS="ttgtgacaactttattaaagattcattttagatATATctttt attcgtaagaTCATGTATTTTAAAGATATAttttaaatacatcttttcgaaaggattg t" /listShort="hmp, S467, ykjA, ykkA" /GFF_Attribute="listLong" /label="upshifts" CDS 1285120..1286319 /gene="hmpA" /locus_tag="BSU_13040" /old_locus_tag="BSU13040" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10658656, 10972836, 12469342, 15231799, 15751990, 16261196, 16517672, 17293416, 24214949, 26786044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10658656, 10972836, 12469342, 15231799, 15751990, 16261196, 16517672, 17293416, 24214949, 26786044; Product type c: carrier" /codon_start=1 /transl_table=11 /product="flavohemoglobin" /protein_id="NP_389187.1" /db_xref="EnsemblGenomes-Gn:BSU13040" /db_xref="EnsemblGenomes-Tr:CAB13161" /db_xref="GOA:P49852" /db_xref="InterPro:IPR000971" /db_xref="InterPro:IPR001221" /db_xref="InterPro:IPR001433" /db_xref="InterPro:IPR008333" /db_xref="InterPro:IPR009050" /db_xref="InterPro:IPR017927" /db_xref="InterPro:IPR017938" /db_xref="InterPro:IPR023950" /db_xref="SubtiList:BG11418" /db_xref="UniProtKB/Swiss-Prot:P49852" /translation="MLDNKTIEIIKSTVPVLQQHGETITGRFYDRMFQDHPELLNIFN QTNQKKKTQRTALANAVIAAAANIDQLGNIIPVVKQIGHKHRSIGIKPEHYPIVGKYL LIAIKDVLGDAATPDIMQAWEKAYGVIADAFIGIEKDMYEQAEEQAGGWKEYKPFVIA KKERESKEITSFYLKPEDSKPLPEFQAGQYISIKVRIPDSEYTHIRQYSLSDMPGKDY YRISVKKDGVVSSYLHDGLQEGDSIEISAPAGDFVLDHASQKDLVLISAGVGITPMIS MLKTSVSKQPERQILFIHAAKNSEYHALRHEVEEAAKHSAVKTAFVYREPTEEDRAGD LHFHEGQIDQQFLKELIANTDADYYICGSPSFITAMHKLVSELGSAPESIHYELFGPQ LSLAQSV*" /label="hmpA CDS" gene 1285120..1286319 /gene="hmpA" /locus_tag="BSU_13040" /old_locus_tag="BSU13040" /label="hmpA gene" downshifts 1286308 /Source="Nicolas_upshifts" /id="D711" /incds=0 /nref=10 /ntot=59 /MaxReadThrough="6.06442" /MaxDrop="4.19301" /score="11.2868967" /energy="-9.3" /TU="U1053" /idTUdmin="U1051" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1286353..1286724 /Source="Nicolas_S_feature" /locus_tag="new_1374025_1374396" /HighExp="nit, B36, B60, Etha, BI, M40t90, LBGtran, M0t90, BT, S6" /AntisenseName="ykzH" /AntisenseCor="7.6554747052539299E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.99" /TUlongSig="SigGF" /TUlongPSig="0.998" /label="S467" CDS complement(1286396..1286620) /gene="ykzH" /locus_tag="BSU_13050" /old_locus_tag="BSU13050" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389188.1" /db_xref="EnsemblGenomes-Gn:BSU13050" /db_xref="EnsemblGenomes-Tr:CAB13162" /db_xref="SubtiList:BG13336" /db_xref="UniProtKB/Swiss-Prot:O31653" /translation="MKNQKSNTLWPFDLPLAPQPEGYQQQTIDRLAGLELRMKQLIRA IEVNNELLRTMQEQQNRVCTNGSGSVIVRM*" /label="ykzH CDS" gene complement(1286396..1286620) /gene="ykzH" /locus_tag="BSU_13050" /old_locus_tag="BSU13050" /label="ykzH gene" promotor_-35 1286700..1286706 /Source="Nicolas_upshift_promotors" /id="U1054" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=927 /SigmaFactorBS="gttcaggcgatatgcacgttcgcctagacactgaTGCATAGa gggcctgccacgGGGCACAATAGGctcaatatgaccagcggatggaggtaaagatcgg t" /listShort="ykjA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1286720..1286731 /Source="Nicolas_upshift_promotors" /id="U1054" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=927 /SigmaFactorBS="gttcaggcgatatgcacgttcgcctagacactgaTGCATAGa gggcctgccacgGGGCACAATAGGctcaatatgaccagcggatggaggtaaagatcgg t" /listShort="ykjA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1286726 /Source="Nicolas_upshifts" /id="U1054" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=927 /SigmaFactorBS="gttcaggcgatatgcacgttcgcctagacactgaTGCATAGa gggcctgccacgGGGCACAATAGGctcaatatgaccagcggatggaggtaaagatcgg t" /listShort="ykjA" /GFF_Attribute="listLong" /label="upshifts" CDS 1286765..1287496 /gene="ykjA" /locus_tag="BSU_13060" /old_locus_tag="BSU13060" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_389189.1" /db_xref="EnsemblGenomes-Gn:BSU13060" /db_xref="EnsemblGenomes-Tr:CAB13163" /db_xref="GOA:P49853" /db_xref="InterPro:IPR007353" /db_xref="InterPro:IPR023090" /db_xref="SubtiList:BG11419" /db_xref="UniProtKB/Swiss-Prot:P49853" /translation="MLWMVWVFLLKPVIVFSIAYILFRLAGKKAVSQMNNFDLLLTFA IGTIISEPILTSKLPMSIYYAGAFLVLYLIMSKLSLSNKWRWLLVVSPTVLIRNGDID ERGLRKERLTVNELLGKLREKGYADPADIDLAIIEETGEVSVIPKEEARAVQVRDLNM EAERNFIPIPLILDGEILDHNLKYLQKNRSWLFEKLEEKGYSPKLLSSIILGTMNARG DISLDLNTANEPQHDPYLYKPGNNN*" /label="ykjA CDS" gene 1286765..1287496 /gene="ykjA" /locus_tag="BSU_13060" /old_locus_tag="BSU13060" /label="ykjA gene" downshifts 1287474 /Source="Nicolas_upshifts" /id="D712" /incds=0 /nref=14 /ntot=29 /MaxReadThrough="2.84532" /MaxDrop="4.44655" /score="17.2468985" /energy="-7.2" /TU="U1053" /idTUdmin="U1054" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1287535..1287543 /Source="Nicolas_upshift_promotors" /id="U1055" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=551 /SigmaFactorBS="ctctctcttgtaatgagagcttttttcttttttAAAGGGAAT ttttgtttggTGTCAAATGTACCTAGTTAggaggggaactgaacatgaaggacttatc c" /listShort="ykkA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1287554..1287572 /Source="Nicolas_upshift_promotors" /id="U1055" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=551 /SigmaFactorBS="ctctctcttgtaatgagagcttttttcttttttAAAGGGAAT ttttgtttggTGTCAAATGTACCTAGTTAggaggggaactgaacatgaaggacttatc c" /listShort="ykkA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1287562 /Source="Nicolas_upshifts" /id="U1055" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=551 /SigmaFactorBS="ctctctcttgtaatgagagcttttttcttttttAAAGGGAAT ttttgtttggTGTCAAATGTACCTAGTTAggaggggaactgaacatgaaggacttatc c" /listShort="ykkA" /GFF_Attribute="listLong" /label="upshifts" CDS 1287588..1288115 /gene="ykkA" /locus_tag="BSU_13070" /old_locus_tag="BSU13070" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389190.1" /db_xref="EnsemblGenomes-Gn:BSU13070" /db_xref="EnsemblGenomes-Tr:CAB13164" /db_xref="InterPro:IPR024775" /db_xref="InterPro:IPR034660" /db_xref="SubtiList:BG11420" /db_xref="UniProtKB/Swiss-Prot:P49854" /translation="MKDLSIRNDMAPTVSLLYSAVEENSLRLASIVSHMTHSELYYKG RCQTKNSTAQLLHHITNVDIRWVWRIKENRIPDHIEQAYGPMTDESGRLPEPVNQPDL DELLKRHQHVVEKLKSVCFTLTENALNQPLSFEGDTATIRWGIWHMADHNRYHQAHIE ALKKEWKQDVAKYER*" /label="ykkA CDS" gene 1287588..1288115 /gene="ykkA" /locus_tag="BSU_13070" /old_locus_tag="BSU13070" /label="ykkA gene" CDS 1288105..1288623 /gene="ykkB" /locus_tag="BSU_13080" /old_locus_tag="BSU13080" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12793527; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_389191.1" /db_xref="EnsemblGenomes-Gn:BSU13080" /db_xref="EnsemblGenomes-Tr:CAB13165" /db_xref="GOA:P49855" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11421" /db_xref="UniProtKB/Swiss-Prot:P49855" /translation="MNAKTKLVTDRIRLRCMEDRDQATLFGLLFNDPDVMTYYSGLKD KRQTREWVNWNQRNEKGYGVSLWIAEDKRTGEFLGQCGIVPQQIENQTVMEIGYMFAR RHWGNGYAQEAARACLDYGFNERQFGKMAALIDPGNKASIRVAEKIGMHYSKTIRKWN KPIAVYERKSYN*" /label="ykkB CDS" gene 1288105..1288623 /gene="ykkB" /locus_tag="BSU_13080" /old_locus_tag="BSU13080" /label="ykkB gene" promotor_-35 1288617..1288624 /Source="Nicolas_upshift_promotors" /id="U1056" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.838161838161838" /psig=1 /xcortree=3144 /SigmaFactorBS="gaataaaccgatcgcggtatatgaaagaaaatcttaCAATTG AAagatagagctgagTTTAGTATCATGATATCATGtaaagttttctagggttccgcat g" /listShort="NA, ykkC, ykkD" /listLong="purU" /label="promotor_-35" promotor_-10 1288638..1288657 /Source="Nicolas_upshift_promotors" /id="U1056" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.838161838161838" /psig=1 /xcortree=3144 /SigmaFactorBS="gaataaaccgatcgcggtatatgaaagaaaatcttaCAATTG AAagatagagctgagTTTAGTATCATGATATCATGtaaagttttctagggttccgcat g" /listShort="NA, ykkC, ykkD" /listLong="purU" /label="promotor_-10" upshifts 1288641 /Source="Nicolas_upshifts" /id="U1056" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.838161838161838" /psig=1 /xcortree=3144 /SigmaFactorBS="gaataaaccgatcgcggtatatgaaagaaaatcttaCAATTG AAagatagagctgagTTTAGTATCATGATATCATGtaaagttttctagggttccgcat g" /listShort="NA, ykkC, ykkD" /listLong="purU" /label="upshifts" misc_RNA 1288656..1288767 /gene="gdwA" /locus_tag="BSU_misc_RNA_16" /product="guanidine-sensing riboswitch (binds free guanidinium)" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17908319, 21317561, 27989440, 28001368, 28017522, 28107646, 28212758; Product type n: RNA" /label="gdwA RNA" gene 1288656..1288767 /gene="gdwA" /locus_tag="BSU_misc_RNA_16" /label="gdwA gene" downshifts 1288730 /Source="Nicolas_upshifts" /id="D713" /incds=0 /nref=205 /ntot=246 /MaxReadThrough="3.70824" /MaxDrop="6.58389" /score="30.3456563" /energy="-18.5" /TU="U1056" /idTUdmin="U1056" /TUdmin="-789" /isTUend="FALSE" /label="downshifts" CDS 1288845..1289183 /gene="gdnC" /locus_tag="BSU_13090" /old_locus_tag="BSU13090" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10735877, 10931887, 15096624, 28001372" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10735877, 10931887, 15096624, 28001372; Product type t: transporter" /codon_start=1 /transl_table=11 /product="guanidinium efflux transporter subunit" /protein_id="NP_389192.1" /db_xref="EnsemblGenomes-Gn:BSU13090" /db_xref="EnsemblGenomes-Tr:CAB13166" /db_xref="GOA:P49856" /db_xref="InterPro:IPR000390" /db_xref="SubtiList:BG11422" /db_xref="UniProtKB/Swiss-Prot:P49856" /translation="MKWGLVVLAAVFEVVWVIGLKHADSALTWSGTAIGIIFSFYLLM KATHSLPVGTVYAVFTGLGTAGTVLSEIVLFHEPVGWPKLLLIGVLLIGVIGLKLVTQ DETEEKGGEA*" /label="gdnC CDS" gene 1288845..1289183 /gene="gdnC" /locus_tag="BSU_13090" /old_locus_tag="BSU13090" /label="gdnC gene" CDS 1289183..1289500 /gene="gdnD" /locus_tag="BSU_13100" /old_locus_tag="BSU13100" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10735877, 10931887, 15096624, 28001372" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10735877, 10931887, 15096624, 28001372; Product type t: transporter" /codon_start=1 /transl_table=11 /product="guanidinium efflux transporter subunit" /protein_id="NP_389193.1" /db_xref="EnsemblGenomes-Gn:BSU13100" /db_xref="EnsemblGenomes-Tr:CAB13167" /db_xref="GOA:P49857" /db_xref="InterPro:IPR000390" /db_xref="SubtiList:BG11423" /db_xref="UniProtKB/Swiss-Prot:P49857" /translation="MLHWISLLCAGCLEMAGVALMNQYAKEKSVKWVLLIIVGFAASF SLLSYAMETTPMGTAYAVWTGIGTAGGALIGILFYKEQKDAKRIFFIALILCSAVGLK ILS*" /label="gdnD CDS" gene 1289183..1289500 /gene="gdnD" /locus_tag="BSU_13100" /old_locus_tag="BSU13100" /label="gdnD gene" promotor_-35 1289500..1289503 /Source="Nicolas_upshift_promotors" /id="U1057" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.647352647352647" /psig="0.998001998001998" /xcortree=2582 /SigmaFactorBS="tcagcagttggtttaaaaattctgtcataAATTgatttttat caaatcTTCAGTATAATGGATAAATAgtttagacttacaaagataagagggattattc a" /listShort="purU, NA, proB, proA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1289519..1289538 /Source="Nicolas_upshift_promotors" /id="U1057" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.647352647352647" /psig="0.998001998001998" /xcortree=2582 /SigmaFactorBS="tcagcagttggtttaaaaattctgtcataAATTgatttttat caaatcTTCAGTATAATGGATAAATAgtttagacttacaaagataagagggattattc a" /listShort="purU, NA, proB, proA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1289531 /Source="Nicolas_upshifts" /id="U1057" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.647352647352647" /psig="0.998001998001998" /xcortree=2582 /SigmaFactorBS="tcagcagttggtttaaaaattctgtcataAATTgatttttat caaatcTTCAGTATAATGGATAAATAgtttagacttacaaagataagagggattattc a" /listShort="purU, NA, proB, proA" /GFF_Attribute="listLong" /label="upshifts" CDS 1289571..1290473 /gene="purU" /locus_tag="BSU_13110" /old_locus_tag="BSU13110" /EC_number="3.5.1.10" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8226647, 24108189; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="formyltetrahydrofolate hydrolase" /protein_id="NP_389194.2" /db_xref="EnsemblGenomes-Gn:BSU13110" /db_xref="EnsemblGenomes-Tr:CAB13168" /db_xref="GOA:O34990" /db_xref="InterPro:IPR002376" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR004810" /db_xref="InterPro:IPR036477" /db_xref="SubtiList:BG13237" /db_xref="UniProtKB/Swiss-Prot:O34990" /translation="MKSYMTQRLDEYRDGNEDKGRLLVSCPDQPGIVSAVSAFLFEHG ANIIESNQYTTDPEGGRFFLRIEFDCAGIREKKSSLQAAFASVAEKFDMTWSLTLASE LKRVAIFVSKELHCLHELIWEWQTGNLMAEIAVVISNHEEARELVERLNIPFHYMKAN KDIRAEVEKKQLELLEQYDVDVIVLARYMQILTPDFVSAHPNRIINIHHSFLPAFIGA NPYKRAYERGVKLIGATSHYVTNDLDEGPIIEQDIERVDHRDNAEALKNIGRTIERSV LARAVKWHLEDRVIVHENKTIVFN*" /label="purU CDS" gene 1289571..1290473 /gene="purU" /locus_tag="BSU_13110" /old_locus_tag="BSU13110" /label="purU gene" downshifts 1290464 /Source="Nicolas_upshifts" /id="D714" /incds=0 /nref=91 /ntot=226 /MaxReadThrough="3.55628" /MaxDrop="5.02155" /score="16.8011006" /energy="-13.1" /TU="U1057" /idTUdmin="U1056" /TUdmin=945 /isTUend="FALSE" /label="downshifts" promotor_-35 1290520..1290526 /Source="Nicolas_upshift_promotors" /id="U1058" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.482517482517482" /psig="0.998001998001998" /xcortree=3136 /SigmaFactorBS="agactgcaagaggcccgcgcaatgcgggctatttttgatgac aaaaaaCCTTGACaagtgtcttttttCTTTGCATAATATAAAAAAAtcattgagcgtt g" /listShort="NA, proB, proA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1290532 /Source="Nicolas_upshifts" /id="U1058" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.482517482517482" /psig="0.998001998001998" /xcortree=3136 /SigmaFactorBS="agactgcaagaggcccgcgcaatgcgggctatttttgatgac aaaaaaCCTTGACaagtgtcttttttCTTTGCATAATATAAAAAAAtcattgagcgtt g" /listShort="NA, proB, proA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1290540..1290559 /Source="Nicolas_upshift_promotors" /id="U1058" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.482517482517482" /psig="0.998001998001998" /xcortree=3136 /SigmaFactorBS="agactgcaagaggcccgcgcaatgcgggctatttttgatgac aaaaaaCCTTGACaagtgtcttttttCTTTGCATAATATAAAAAAAtcattgagcgtt g" /listShort="NA, proB, proA" /GFF_Attribute="listLong" /label="promotor_-10" misc_RNA 1290561..1290771 /gene="pswB" /locus_tag="BSU_misc_RNA_17" /product="T-box riboswitch specific of proline tRNA" /experiment="publication(s) with functional evidences, PMID:11917026, 12749771, 19932103, 21233158" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11917026, 12749771, 19932103, 21233158; Product type n: RNA" /function="16.3: Control" /label="pswB RNA" gene 1290561..1290771 /gene="pswB" /locus_tag="BSU_misc_RNA_17" /label="pswB gene" downshifts 1290729 /Source="Nicolas_upshifts" /id="D715" /incds=0 /nref=4 /ntot=52 /MaxReadThrough="6.91996" /MaxDrop="3.8361" /score="29.5878921" /energy="-17.6" /TU="U1057,U1058" /idTUdmin="U1056" /TUdmin=1210 /isTUend="FALSE" /label="downshifts" CDS 1290824..1291921 /gene="proB" /locus_tag="BSU_13120" /old_locus_tag="BSU13120" /EC_number="2.7.2.11" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:16958849, 8083159, 21233158, 21784929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16958849, 8083159, 21233158, 21784929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate 5-kinase" /protein_id="NP_389195.2" /db_xref="EnsemblGenomes-Gn:BSU13120" /db_xref="EnsemblGenomes-Tr:CAB13169" /db_xref="GOA:P39820" /db_xref="InterPro:IPR001048" /db_xref="InterPro:IPR001057" /db_xref="InterPro:IPR002478" /db_xref="InterPro:IPR005715" /db_xref="InterPro:IPR011529" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR019797" /db_xref="InterPro:IPR036393" /db_xref="InterPro:IPR036974" /db_xref="SubtiList:BG10963" /db_xref="UniProtKB/Swiss-Prot:P39820" /translation="MKKQRIVVKIGSSSLTNSKGSIDEAKIREHVQAISVLKKAGHEM ILITSGAVAAGFSSLGYPSRPVTIKGKQAAAAVGQTLLMQQYMNQFKQYSLTPGQILL TRNDFSKRERYRNAYATIMELLERGVIPIINENDSTSVEELTFGDNDMLSALVSGLIH ADQLMILTDINGLYDANPNENPEAKRFDYLPEITPELLGYAGSAGSKVGTGGMKSKLL ATQTALSLGVKVFIGTGSGEQKLADILDGRGDGTYIGDKELSSVNNTRQWIQFHSPIS GEIIIDAGAEEAMIHNGSSLLPAGVVGVNGSFPKGAVVEVRGPGGVIGKGQTHYSSEE IMEAKGKRSDELDFEKTFEVIHRNDWVNVKD*" /label="proB CDS" gene 1290824..1291921 /gene="proB" /locus_tag="BSU_13120" /old_locus_tag="BSU13120" /label="proB gene" promotor_-35 1291011..1291013 /Source="Nicolas_upshift_promotors" /id="U1059" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.365634365634366" /psig="0.206793206793207" /xcortree=1776 /SigmaFactorBS="gattctgattacctcgggtgccgtagcggcggggttttccag cctcggttatccatCCCgTCCCGttaccatcaaaggaaaacaggcggcggccgcggtc g" /listShort="proA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1291015..1291019 /Source="Nicolas_upshift_promotors" /id="U1059" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.365634365634366" /psig="0.206793206793207" /xcortree=1776 /SigmaFactorBS="gattctgattacctcgggtgccgtagcggcggggttttccag cctcggttatccatCCCgTCCCGttaccatcaaaggaaaacaggcggcggccgcggtc g" /listShort="proA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1291015 /Source="Nicolas_upshifts" /id="U1059" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.365634365634366" /psig="0.206793206793207" /xcortree=1776 /SigmaFactorBS="gattctgattacctcgggtgccgtagcggcggggttttccag cctcggttatccatCCCgTCCCGttaccatcaaaggaaaacaggcggcggccgcggtc g" /listShort="proA" /GFF_Attribute="listLong" /label="upshifts" CDS 1291933..1293180 /gene="proA" /locus_tag="BSU_13130" /old_locus_tag="BSU13130" /EC_number="1.2.1.41" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:16958849, 8083159, 21784929, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16958849, 8083159, 21784929, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="gamma-glutamyl phosphate reductase" /protein_id="NP_389196.2" /db_xref="EnsemblGenomes-Gn:BSU13130" /db_xref="EnsemblGenomes-Tr:CAB13170" /db_xref="GOA:P39821" /db_xref="InterPro:IPR000965" /db_xref="InterPro:IPR012134" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR020593" /db_xref="SubtiList:BG10964" /db_xref="UniProtKB/Swiss-Prot:P39821" /translation="MSEVSVKAKLAKEAAAEMIMKTTAEKDEALSLIANGLRKELDFL LAENAKDIVNGKENGLTPDIIDRLSLDEKRIRDIADAVELLIDLADPIGDSLETIEKE NGLFIEKIRVPLGVVGMIYEARPNVTVDAATLCLKTGNAVVLRGSSSAIHSNKALVSV IYRALEQSALPIHAVQLIEDTSRETAKELFTLNDGLDVLIPRGGKKLIDLVVRESTVP VLETGAGNCHIFIDETAKPQMAEKVVVNAKTQRPSVCNAIESLLIHKAWARQHGKELL DQLENAGVEIRGDELVCELHPSSKQASKEDWETEFLAPVLSVKTVENVQEAVKHIQQY GTNHSEAILTENDKNAVYFQTAVDAAAVYHNASTRFTDGFEFGYGAEIGISTQKLHAR GPMGLPALTSTKYIIKGTGQIRE*" /label="proA CDS" gene 1291933..1293180 /gene="proA" /locus_tag="BSU_13130" /old_locus_tag="BSU13130" /label="proA gene" downshifts 1293171 /Source="Nicolas_upshifts" /id="D716" /incds=0 /nref=120 /ntot=228 /MaxReadThrough="4.1607" /MaxDrop="6.017" /score="11.118012" /energy="-11" /TU="U1058" /idTUdmin="U1059" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1293242..1293249 /Source="Nicolas_upshift_promotors" /id="U1060" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.947052947052947" /psig=1 /xcortree=3016 /SigmaFactorBS="ttacgagataagcttttttatacgcgaaaAATTGACAtttca aatttaattGTGTACAATTTAATTGTATAaaatatattgggggaatgaaaaatgagtc a" /listShort="ohrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1293264..1293283 /Source="Nicolas_upshift_promotors" /id="U1060" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.947052947052947" /psig=1 /xcortree=3016 /SigmaFactorBS="ttacgagataagcttttttatacgcgaaaAATTGACAtttca aatttaattGTGTACAATTTAATTGTATAaaatatattgggggaatgaaaaatgagtc a" /listShort="ohrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1293273 /Source="Nicolas_upshifts" /id="U1060" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.947052947052947" /psig=1 /xcortree=3016 /SigmaFactorBS="ttacgagataagcttttttatacgcgaaaAATTGACAtttca aatttaattGTGTACAATTTAATTGTATAaaatatattgggggaatgaaaaatgagtc a" /listShort="ohrA" /GFF_Attribute="listLong" /label="upshifts" CDS 1293306..1293731 /gene="ohrA" /locus_tag="BSU_13140" /old_locus_tag="BSU13140" /EC_number="1.11.1.15" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11418552, 17502599, 21749987, 24184231" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418552, 17502599, 21749987, 24184231; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peroxiredoxin" /protein_id="NP_389197.1" /db_xref="EnsemblGenomes-Gn:BSU13140" /db_xref="EnsemblGenomes-Tr:CAB13171" /db_xref="GOA:O34762" /db_xref="InterPro:IPR003718" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR019953" /db_xref="InterPro:IPR036102" /db_xref="SubtiList:BG13238" /db_xref="UniProtKB/Swiss-Prot:O34762" /translation="MSQPLFTATVSAVGGREGKVISSDRVLELDVAMPGTPRAKKLEK ATNPEQLFAAGYAACFDSALQLVARTERVKVETEVTANVSLLKDEADQGYKLGVTLQV KGEGVSASELEALVKKAHGVCPYSKATSGNIDVTLEVAE*" /label="ohrA CDS" gene 1293306..1293731 /gene="ohrA" /locus_tag="BSU_13140" /old_locus_tag="BSU13140" /label="ohrA gene" downshifts 1293720 /Source="Nicolas_upshifts" /id="D717" /incds=0 /nref=57 /ntot=174 /MaxReadThrough="0.0429100000000009" /MaxDrop="3.90314" /score="30.9245751" /energy="-16.6" /TU="NA" /idTUdmin="U1060" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1293762..1294205) /gene="ohrR" /locus_tag="BSU_13150" /old_locus_tag="BSU13150" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11983871, 17502599, 18363800, 20094649, 21749987, 24184231" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11983871, 17502599, 18363800, 20094649, 21749987, 24184231; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator sensing organic peroxides" /protein_id="NP_389198.1" /db_xref="EnsemblGenomes-Gn:BSU13150" /db_xref="EnsemblGenomes-Tr:CAB13172" /db_xref="GOA:O34777" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:1Z91" /db_xref="PDB:1Z9C" /db_xref="SubtiList:BG13239" /db_xref="UniProtKB/Swiss-Prot:O34777" /translation="MENKFDHMKLENQLCFLLYASSREMTKQYKPLLDKLNITYPQYL ALLLLWEHETLTVKKMGEQLYLDSGTLTPMLKRMEQQGLITRKRSEEDERSVLISLTE DGALLKEKAVDIPGTILGLSKQSGEDLKQLKSALYTLLETLHQKN*" /label="ohrR CDS" gene complement(1293762..1294205) /gene="ohrR" /locus_tag="BSU_13150" /old_locus_tag="BSU13150" /label="ohrR gene" downshifts complement(1293796) /Source="Nicolas_upshifts" /id="D718" /incds=0 /nref=105 /ntot=232 /MaxReadThrough="-0.17111" /MaxDrop="4.73026" /score="34.7008532" /energy="-16.6" /TU="NA" /idTUdmin="U1061" /TUdmin=1 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1294232..1294251) /Source="Nicolas_upshift_promotors" /id="U1061" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig=1 /xcortree=2020 /SigmaFactorBS="tctttttaaacatgctatgtttgccgagaATAGgaaaagtga ggtttTTCAGATACAATAGAATCGAatgacaaaaaagagttggtgaacaaaatggaaa a" /listShort="ohrR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1294238) /Source="Nicolas_upshifts" /id="U1061" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig=1 /xcortree=2020 /SigmaFactorBS="tctttttaaacatgctatgtttgccgagaATAGgaaaagtga ggtttTTCAGATACAATAGAATCGAatgacaaaaaagagttggtgaacaaaatggaaa a" /listShort="ohrR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1294266..1294269) /Source="Nicolas_upshift_promotors" /id="U1061" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig=1 /xcortree=2020 /SigmaFactorBS="tctttttaaacatgctatgtttgccgagaATAGgaaaagtga ggtttTTCAGATACAATAGAATCGAatgacaaaaaagagttggtgaacaaaatggaaa a" /listShort="ohrR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1294287..1294293 /Source="Nicolas_upshift_promotors" /id="U1062" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=232 /SigmaFactorBS="aacctcacttttcctattctcggcaaacatagcaTGTTTAAa aagatcagaaagGGAAATATAACAACTAGATacaaataaggaggttgggaaatatggc a" /listShort="ohrB, ykzN, S468" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1294307..1294325 /Source="Nicolas_upshift_promotors" /id="U1062" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=232 /SigmaFactorBS="aacctcacttttcctattctcggcaaacatagcaTGTTTAAa aagatcagaaagGGAAATATAACAACTAGATacaaataaggaggttgggaaatatggc a" /listShort="ohrB, ykzN, S468" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1294313 /Source="Nicolas_upshifts" /id="U1062" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=232 /SigmaFactorBS="aacctcacttttcctattctcggcaaacatagcaTGTTTAAa aagatcagaaagGGAAATATAACAACTAGATacaaataaggaggttgggaaatatggc a" /listShort="ohrB, ykzN, S468" /GFF_Attribute="listLong" /label="upshifts" CDS 1294348..1294758 /gene="ohrB" /locus_tag="BSU_13160" /old_locus_tag="BSU13160" /EC_number="1.11.1.15" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9696771, 11418552, 18084074" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9696771, 11418552, 18084074; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="organic hydroperoxide resistance reductase B" /protein_id="NP_389199.1" /db_xref="EnsemblGenomes-Gn:BSU13160" /db_xref="EnsemblGenomes-Tr:CAB13173" /db_xref="GOA:P80242" /db_xref="InterPro:IPR003718" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR019953" /db_xref="InterPro:IPR036102" /db_xref="PDB:2BJO" /db_xref="SubtiList:BG19021" /db_xref="UniProtKB/Swiss-Prot:P80242" /translation="MALFTAKVTARGGRAGHITSDDGVLDFDIVMPNAKKEGQTGTNP EQLFAAGYAACFGGALEHVAKEQNIEIDSEIEGQVSLMKDESDGGFKIGVTLVVNTKD LDREKAQELVNAAHEFCPYSKATRGNVDVKLELK*" /label="ohrB CDS" gene 1294348..1294758 /gene="ohrB" /locus_tag="BSU_13160" /old_locus_tag="BSU13160" /label="ohrB gene" downshifts 1294736 /Source="Nicolas_upshifts" /id="D719" /incds=0 /nref=7 /ntot=145 /MaxReadThrough="8.17185" /MaxDrop="4.0663" /score="17.6512157" /energy="-12.1" /TU="U1062" /idTUdmin="U1062" /TUdmin="-855" /isTUend="FALSE" /label="downshifts" CDS 1294785..1294955 /gene="ykzN" /locus_tag="BSU_13169" /old_locus_tag="BSU13169" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097717.1" /db_xref="EnsemblGenomes-Gn:BSU13169" /db_xref="EnsemblGenomes-Tr:CAX52607" /db_xref="UniProtKB/Swiss-Prot:C0H400" /translation="MFFGVGHAGRAQIYDKTSEKRLKHAFKPKVTDEAGGWHGVCRAE LRVYAVLYLHRA*" /label="ykzN CDS" gene 1294785..1294955 /gene="ykzN" /locus_tag="BSU_13169" /old_locus_tag="BSU13169" /label="ykzN gene" S_feature 1294956..1295633 /Source="Nicolas_S_feature" /locus_tag="new_1382628_1383305" /HighExp="Etha, Salt, M9-stat, Sw, B60, LPhT, B36, Heat, Gly, BC" /AntisenseName="guaD" /AntisenseCor="-5.7732597431508298E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S468" CDS complement(1295005..1295475) /gene="guaN" /locus_tag="BSU_13170" /old_locus_tag="BSU13170" /EC_number="3.5.4.3" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11101664, 15180998" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11101664, 15180998; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="guanine deaminase" /protein_id="NP_389200.1" /db_xref="EnsemblGenomes-Gn:BSU13170" /db_xref="EnsemblGenomes-Tr:CAB13174" /db_xref="GOA:O34598" /db_xref="InterPro:IPR002125" /db_xref="InterPro:IPR016192" /db_xref="InterPro:IPR016193" /db_xref="PDB:1TIY" /db_xref="PDB:1WKQ" /db_xref="SubtiList:BG13240" /db_xref="UniProtKB/Swiss-Prot:O34598" /translation="MNHETFLKRAVTLACEGVNAGIGGPFGAVIVKDGAIIAEGQNNV TTSNDPTAHAEVTAIRKACKVLGAYQLDDCILYTSCEPCPMCLGAIYWARPKAVFYAA EHTDAAEAGFDDSFIYKEIDKPAEERTIPFYQVTLTEHLSPFQAWRNFANKKEY*" /label="guaN CDS" gene complement(1295005..1295475) /gene="guaN" /locus_tag="BSU_13170" /old_locus_tag="BSU13170" /label="guaN gene" downshifts complement(1295029) /Source="Nicolas_upshifts" /id="D720" /incds=0 /nref=25 /ntot=112 /MaxReadThrough="0.698199999999999" /MaxDrop="4.30578" /score="-6.41557266" /energy="-13.5" /TU="NA" /idTUdmin="U1063" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1295497..1295516) /Source="Nicolas_upshift_promotors" /id="U1063" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.434565434565435" /psig="0.933066933066933" /xcortree=790 /SigmaFactorBS="atcccccaaatactttgtttattttgcacttttttaagAATG ttctttgcattctttTCGGCTATACTAATAACACTctattgacaggagggattgggat g" /listShort="guaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1295513) /Source="Nicolas_upshifts" /id="U1063" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.434565434565435" /psig="0.933066933066933" /xcortree=790 /SigmaFactorBS="atcccccaaatactttgtttattttgcacttttttaagAATG ttctttgcattctttTCGGCTATACTAATAACACTctattgacaggagggattgggat g" /listShort="guaD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1295515..1295622) /Source="Nicolas_S_feature" /locus_tag="new_1383187_1383294_c" /HighExp="BMM, MG 10, MG 15, MG 5, MG t5, GM 25, B36, Gly, B60, GM 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.044, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S469" promotor_-35 complement(1295532..1295535) /Source="Nicolas_upshift_promotors" /id="U1063" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.434565434565435" /psig="0.933066933066933" /xcortree=790 /SigmaFactorBS="atcccccaaatactttgtttattttgcacttttttaagAATG ttctttgcattctttTCGGCTATACTAATAACACTctattgacaggagggattgggat g" /listShort="guaD" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1295591 /Source="Nicolas_upshifts" /id="D721" /incds=0 /nref=9 /ntot=34 /MaxReadThrough="0.95942" /MaxDrop="5.95076" /score="15.2916843" /energy="-11.5" /TU="NA" /idTUdmin="U1062" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1295648..1297936) /gene="metE" /locus_tag="BSU_13180" /old_locus_tag="BSU13180" /EC_number="2.1.1.14" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8755891, 10094622, 12910260, 16086852, 16194229, 17012790, 17611193, 21749987, 22938038, 24313874" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8755891, 10094622, 12910260, 16086852, 16194229, 17012790, 17611193, 21749987, 22938038, 24313874; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cobalamin-independent methionine synthase" /protein_id="NP_389201.2" /db_xref="EnsemblGenomes-Gn:BSU13180" /db_xref="EnsemblGenomes-Tr:CAB13175" /db_xref="GOA:P80877" /db_xref="InterPro:IPR002629" /db_xref="InterPro:IPR006276" /db_xref="InterPro:IPR013215" /db_xref="SubtiList:BG12616" /db_xref="UniProtKB/Swiss-Prot:P80877" /translation="MTTIKTSNLGFPRIGLNREWKKALEAYWKGSTDKDTFLKQIDEL FLSAVKTQIDQQIDVVPVSDFTQYDHVLDTAVSFNWIPKRFRHLTDATDTYFAIARGI KDAVSSEMTKWFNTNYHYIVPEYDESIEFRLTRNKQLEDYRRIKQEYGVETKPVIVGP YTFVTLAKGYEPSEAKAIQKRLVPLYVQLLKELEEEGVKWVQIDEPALVTASSEDVRG AKELFESITSELSSLNVLLQTYFDSVDAYEELISYPVQGIGLDFVHDKGRNLEQLKTH GFPTDKVLAAGVIDGRNIWKADLEERLDAVLDILSIAKVDELWIQPSSSLLHVPVAKH PDEHLEKDLLNGLSYAKEKLAELTALKEGLVSGKAAISEEIQQAKADIQALKQFATGA NSEQKKELEQLTDKDFKRPIPFEERLALQNESLGLPLLPTTTIGSFPQSAEVRSARQK WRKAEWSDEQYQNFINAETKRWIDIQEELELDVLVHGEFERTDMVEYFGEKLAGFAFT KYAWVQSYGSRCVRPPVIYGDVEFIEPMTVKDTVYAQSLTSKHVKGMLTGPVTILNWS FPRNDISRKEIAFQIGLALRKEVKALEDAGIQIIQVDEPALREGLPLKTRDWDEYLTW AAEAFRLTTSSVKNETQIHTHMCYSNFEDIVDTINDLDADVITIEHSRSHGGFLDYLK NHPYLKGLGLGVYDIHSPRVPSTEEMYNIIVDALAVCPTDRFWVNPDCGLKTRQQEET VAALKNMVEAAKQARAQQTQLV*" /label="metE CDS" gene complement(1295648..1297936) /gene="metE" /locus_tag="BSU_13180" /old_locus_tag="BSU13180" /label="metE gene" downshifts complement(1295667) /Source="Nicolas_upshifts" /id="D722" /incds=0 /nref=212 /ntot=239 /MaxReadThrough="5.25958" /MaxDrop="7.50935" /score="29.3354648" /energy="-11.5" /TU="U1064,U1065" /idTUdmin="U1063" /TUdmin="-638" /isTUend="FALSE" /label="downshifts" S_feature complement(1297937..1297999) /Source="Nicolas_S_feature" /locus_tag="new_1385609_1385671_c" /HighExp="MG 15, MG 5, MG t5, BMM, T-1.40H, MG 25, MG 10, GM 25, Mal, Etha" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigA" /TUshortPSig="0.044, 1, 0.587" /TUlongSig="NA" /TUlongPSig="NA" /label="S470" promotor_no_box complement(1297959..1298059) /Source="Nicolas_upshift_promotors" /id="U1064" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.332667332667333" /psig="0.043956043956044" /xcortree=3023 /SigmaFactorBS="agtgttttacgtagaaaagcctctttctctcatgggaaagag gctttttgttgtgagaaaacctcttagcagcctgtatccgcgggtgaaagagagtgtt t" /listShort="S470, metE, S469, guaD" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1297999) /Source="Nicolas_upshifts" /id="U1064" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.332667332667333" /psig="0.043956043956044" /xcortree=3023 /SigmaFactorBS="agtgttttacgtagaaaagcctctttctctcatgggaaagag gctttttgttgtgagaaaacctcttagcagcctgtatccgcgggtgaaagagagtgtt t" /listShort="S470, metE, S469, guaD" /GFF_Attribute="listLong" /label="upshifts" misc_RNA complement(1298064..1298219) /gene="mswB" /locus_tag="BSU_misc_RNA_18" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762, 22543867" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762, 22543867; Product type n : RNA" /function="16.3: Control" /label="mswB RNA" gene complement(1298064..1298219) /gene="mswB" /locus_tag="BSU_misc_RNA_18" /label="mswB gene" downshifts complement(1298065) /Source="Nicolas_upshifts" /id="D723" /incds=0 /nref=55 /ntot=106 /MaxReadThrough="8.12248" /MaxDrop="6.4813" /score="24.0596293" /energy="-16.2" /TU="U1065,U1066" /idTUdmin="U1066" /TUdmin="-308" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1298252..1298271) /Source="Nicolas_upshift_promotors" /id="U1065" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2888 /SigmaFactorBS="acatcatgtaaataaaaatttcaaattctaTGTTGACAatga atttgaattacTGTTAAGATTACCAACAAATgattcaacttttcaaaaaattaataac a" /listShort="NA, S470, metE, S469, guaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1298264) /Source="Nicolas_upshifts" /id="U1065" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2888 /SigmaFactorBS="acatcatgtaaataaaaatttcaaattctaTGTTGACAatga atttgaattacTGTTAAGATTACCAACAAATgattcaacttttcaaaaaattaataac a" /listShort="NA, S470, metE, S469, guaD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1298266..1298351) /Source="Nicolas_S_feature" /locus_tag="new_1385938_1386023_c" /HighExp="BT, BC, B36, M9-stat, T5.0H, S3, S6, T4.0H, S5, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.587" /TUlongSig="NA" /TUlongPSig="NA" /label="S471" promotor_-35 complement(1298287..1298294) /Source="Nicolas_upshift_promotors" /id="U1065" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2888 /SigmaFactorBS="acatcatgtaaataaaaatttcaaattctaTGTTGACAatga atttgaattacTGTTAAGATTACCAACAAATgattcaacttttcaaaaaattaataac a" /listShort="NA, S470, metE, S469, guaD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1298352..1299311) /gene="ispA" /locus_tag="BSU_13190" /old_locus_tag="BSU13190" /EC_number="3.4.21.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:3087947, 14680823, 23569278" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3087947, 14680823, 23569278; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="intracellular serine protease" /protein_id="NP_389202.1" /db_xref="EnsemblGenomes-Gn:BSU13190" /db_xref="EnsemblGenomes-Tr:CAB13176" /db_xref="GOA:P11018" /db_xref="InterPro:IPR000209" /db_xref="InterPro:IPR015500" /db_xref="InterPro:IPR022398" /db_xref="InterPro:IPR023827" /db_xref="InterPro:IPR023828" /db_xref="InterPro:IPR034202" /db_xref="InterPro:IPR036852" /db_xref="SubtiList:BG10674" /db_xref="UniProtKB/Swiss-Prot:P11018" /translation="MNGEIRLIPYVTNEQIMDVNELPEGIKVIKAPEMWAKGVKGKNI KVAVLDTGCDTSHPDLKNQIIGGKNFTDDDGGKEDAISDYNGHGTHVAGTIAANDSNG GIAGVAPEASLLIVKVLGGENGSGQYEWIINGINYAVEQKVDIISMSLGGPSDVPELK EAVKNAVKNGVLVVCAAGNEGDGDERTEELSYPAAYNEVIAVGSVSVARELSEFSNAN KEIDLVAPGENILSTLPNKKYGKLTGTSMAAPHVSGALALIKSYEEESFQRKLSESEV FAQLIRRTLPLDIAKTLAGNGFLYLTAPDELAEKAEQSHLLTL*" /label="ispA CDS" gene complement(1298352..1299311) /gene="ispA" /locus_tag="BSU_13190" /old_locus_tag="BSU13190" /label="ispA gene" S_feature complement(1299312..1299363) /Source="Nicolas_S_feature" /locus_tag="new_1386984_1387035_c" /HighExp="BT, B36, BC, T5.0H, M9-stat, T0.30H, T3.30H, T3.0H, T4.0H, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.587" /TUlongSig="NA" /TUlongPSig="NA" /label="S472" promotor_-10 complement(1299356..1299375) /Source="Nicolas_upshift_promotors" /id="U1066" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.358641358641359" /psig="0.587412587412587" /xcortree=465 /SigmaFactorBS="tgtatcctattttttcaaaatgcttcaaatggcTCTGTCCga gcgcttgctttTTTCATATAATATGAGGCAAcacccttgaatccacttgcaagcataa a" /listShort="S472, ispA, S471, NA, S470, metE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1299368) /Source="Nicolas_upshifts" /id="U1066" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.358641358641359" /psig="0.587412587412587" /xcortree=465 /SigmaFactorBS="tgtatcctattttttcaaaatgcttcaaatggcTCTGTCCga gcgcttgctttTTTCATATAATATGAGGCAAcacccttgaatccacttgcaagcataa a" /listShort="S472, ispA, S471, NA, S470, metE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1299389..1299395) /Source="Nicolas_upshift_promotors" /id="U1066" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.358641358641359" /psig="0.587412587412587" /xcortree=465 /SigmaFactorBS="tgtatcctattttttcaaaatgcttcaaatggcTCTGTCCga gcgcttgctttTTTCATATAATATGAGGCAAcacccttgaatccacttgcaagcataa a" /listShort="S472, ispA, S471, NA, S470, metE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1299480..1299483 /Source="Nicolas_upshift_promotors" /id="U1067" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.3996003996004" /psig=1 /xcortree=2359 /SigmaFactorBS="gaattagtaatcttcaaaatattggatggcttcaacatgtat gaCTGGgattcaactgtaagtCAAGTTATAATAGTGTTGGGgaaaggagcagtgtcat g" /listShort="rsbRB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1299496 /Source="Nicolas_upshifts" /id="U1067" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.3996003996004" /psig=1 /xcortree=2359 /SigmaFactorBS="gaattagtaatcttcaaaatattggatggcttcaacatgtat gaCTGGgattcaactgtaagtCAAGTTATAATAGTGTTGGGgaaaggagcagtgtcat g" /listShort="rsbRB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1299499..1299518 /Source="Nicolas_upshift_promotors" /id="U1067" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.3996003996004" /psig=1 /xcortree=2359 /SigmaFactorBS="gaattagtaatcttcaaaatattggatggcttcaacatgtat gaCTGGgattcaactgtaagtCAAGTTATAATAGTGTTGGGgaaaggagcagtgtcat g" /listShort="rsbRB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1299534..1300367 /gene="rsbRB" /locus_tag="BSU_13200" /old_locus_tag="BSU13200" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15312768, 15583165, 17158665" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15312768, 15583165, 17158665; Product type f: factor" /codon_start=1 /transl_table=11 /product="component of the anxiosome (stressosome)" /protein_id="NP_389203.1" /db_xref="EnsemblGenomes-Gn:BSU13200" /db_xref="EnsemblGenomes-Tr:CAB13177" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR036513" /db_xref="SubtiList:BG12609" /db_xref="UniProtKB/Swiss-Prot:O34860" /translation="MKLNEKLYAFFSEHVEQMAEEWIETMEESDPNSLYALHNATVTE ELKEQDREFYRHLNYMYVLPEKQFLEEFQEWVIELTNDQKHLDTPVQYVIREFMRNRR LYTKYFEKFAEENESAFEPGEKQKWADLIVKVFDFTIYTFVDHAEMNAKQQLNAQREM ILELSSPVITLSKSTALLPLVGDIDTERAKFILENTLQACAKRRVEHLLIDLSGVVVV DTMVAHQIFKLIEALNLIGVRSTLSGIRPEIAQTAVQLGIDFSNITIKTNLAQALNYH Q*" /label="rsbRB CDS" gene 1299534..1300367 /gene="rsbRB" /locus_tag="BSU_13200" /old_locus_tag="BSU13200" /label="rsbRB gene" downshifts 1300343 /Source="Nicolas_upshifts" /id="D724" /incds=0 /nref=219 /ntot=254 /MaxReadThrough="3.01586" /MaxDrop="6.07238" /score="22.2655638" /energy="-12.1" /TU="NA" /idTUdmin="U1067" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1300398..1301162) /gene="thiX" /locus_tag="BSU_13210" /old_locus_tag="BSU13210" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16291685, 16356850, 16850406, 18931129" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16291685, 16356850, 16850406, 18931129; Product type t : transporter" /codon_start=1 /transl_table=11 /product="thiamine transporter, transmembrane T component" /protein_id="NP_389204.1" /db_xref="EnsemblGenomes-Gn:BSU13210" /db_xref="EnsemblGenomes-Tr:CAB13178" /db_xref="GOA:O34572" /db_xref="InterPro:IPR003339" /db_xref="SubtiList:BG13248" /db_xref="UniProtKB/Swiss-Prot:O34572" /translation="MKQPLHLINPTVKAAAVFCCVVMLSFIYNPYTPACFYIIIVAGV LLAAGIPLKKWLLFTIPFLILAFGCVWTAAVFGKVPTTPDNFLFQAGPISINSDNVSV GISLGFRILCFSALSMMFVFTTDPILFMLSLVQQCRLSPKLAYGVIAGFRFLPLLKDE VQLIQQAHKIRGGAAESGIINKISALKRYTIPLLASAIRKAERTALAMESKGFTGSRN RTYYRTLSVNRRDWVFFCLVLLLFAGSFLVSLCFAS*" /label="thiX CDS" gene complement(1300398..1301162) /gene="thiX" /locus_tag="BSU_13210" /old_locus_tag="BSU13210" /label="thiX gene" downshifts complement(1300419) /Source="Nicolas_upshifts" /id="D725" /incds=0 /nref=143 /ntot=164 /MaxReadThrough="0.824010000000001" /MaxDrop="6.67697" /score="34.7739353" /energy="-12.1" /TU="NA" /idTUdmin="U1069" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1301137..1302780) /gene="thiW" /locus_tag="BSU_13220" /old_locus_tag="BSU13220" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16291685, 16356850, 16850406, 18931129" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16291685, 16356850, 16850406, 18931129; Product type t : transporter" /codon_start=1 /transl_table=11 /product="thiamine ABC transporter (ATP-binding subunit)" /protein_id="NP_389205.2" /db_xref="EnsemblGenomes-Gn:BSU13220" /db_xref="EnsemblGenomes-Tr:CAB13179" /db_xref="GOA:O34362" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13249" /db_xref="UniProtKB/Swiss-Prot:O34362" /translation="MQAFDELLTVEQLSFSYEEDEKPVFQDISFELQKGECVLLLGPS GCGKSSLALCLNGLYPEACDGIQSGHVFLFQKPVTDAETSETITQHAGVVFQDPDQQF CMLTVEDEIAFGLENLQIPKEEMTEKINAVLEKLRITHLKEKMISTLSGGQKQKVALA CILAMEPELIILDEPTSLLDPFSAREFVHLMKDLQREKGFSLLVIEHQLDEWAPWIER TIVLDKSGKKALDGLTKNLFQHEAETLKKLGIAIPKVCHLQEKLSMPFTLSKEMLFKE PIPAGHVKKKKAPSGESVLEVSSLSFARGQQAIFKDISFSLREGSLTALVGPNGTGKS TLLSVLASLMKPQSGKILLYDQPLQKYKEKELRKRMGFVFQNPEHQFVTDTVYDELLF GQKANAETEKKAQHLLQRFGLAHLADHHPFAISQGQKRRLSVATMLMHDVKVLLLDEP TFGQDARTAAECMEMIQRIKAEGTAVLMITHDMELVSSYADSVLVLHDTGLAFDGSPA QLFSQETGLVQKAKLTLPLLYEWMAFQEEVRDEATVTSH*" /label="thiW CDS" gene complement(1301137..1302780) /gene="thiW" /locus_tag="BSU_13220" /old_locus_tag="BSU13220" /label="thiW gene" CDS complement(1302767..1303366) /gene="thiV" /locus_tag="BSU_13230" /old_locus_tag="BSU13230" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16291685, 16356850, 16850406, 27447050, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16291685, 16356850, 16850406, 27447050, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="thiamine transporter, permease component" /protein_id="NP_389206.2" /db_xref="EnsemblGenomes-Gn:BSU13230" /db_xref="EnsemblGenomes-Tr:CAB13180" /db_xref="GOA:O34738" /db_xref="InterPro:IPR017195" /db_xref="PDB:5EDL" /db_xref="SubtiList:BG13250" /db_xref="UniProtKB/Swiss-Prot:O34738" /translation="MKSWKVKEIVIMSVISIVFAVVYLLFTHFGNVLAGMFGPIAYEP IYGIWFIVSVIAAYMIRKPGAALVSEIIAALVECLLGNPSGPMVIVIGIVQGLGAEAV FLATRWKAYSLPVLMLAGMGSSVASFIYDLFVSGYAAYSPGYLLIMLVIRLISGALLA GLLGKAVSDSLAYTGVLNGMALGKELKKKRKRASEHASL*" /label="thiV CDS" gene complement(1302767..1303366) /gene="thiV" /locus_tag="BSU_13230" /old_locus_tag="BSU13230" /label="thiV gene" CDS complement(1303368..1303970) /gene="thiU" /locus_tag="BSU_13240" /old_locus_tag="BSU13240" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15451668, 16291685, 16356850, 20471400" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15451668, 16291685, 16356850, 20471400; Product type f: factor" /codon_start=1 /transl_table=11 /product="thiamine-binding protein (oxidation stress protein)" /protein_id="NP_389207.1" /db_xref="EnsemblGenomes-Gn:BSU13240" /db_xref="EnsemblGenomes-Tr:CAB13181" /db_xref="GOA:O34911" /db_xref="InterPro:IPR011522" /db_xref="InterPro:IPR015835" /db_xref="InterPro:IPR029756" /db_xref="PDB:1S7H" /db_xref="PDB:1S99" /db_xref="PDB:1SBR" /db_xref="SubtiList:BG13251" /db_xref="UniProtKB/Swiss-Prot:O34911" /translation="MEHICGTSRIAGFRFSLYPMTDDFISVIKSALKKTDTSKVWTKT DHISTVLRGSIDHVFDAAKAIYLHAANSEQHIVMNGTFSIGCPGDTQGDTYLSKGDKR VNEDAVRGLKAEAPCQFALYPMNEPDYMGLIMEAVDIAKAQGTFVQGVHYASELDGDA HDVFSTLEAVFRMAEQQTNHITMTVNLSANSPSRKNRKQG*" /label="thiU CDS" gene complement(1303368..1303970) /gene="thiU" /locus_tag="BSU_13240" /old_locus_tag="BSU13240" /label="thiU gene" downshifts complement(1304048) /Source="Nicolas_upshifts" /id="D726" /incds=0 /nref=28 /ntot=88 /MaxReadThrough="7.47395" /MaxDrop="5.73297" /score="19.7469386" /energy="-10.9" /TU="U1069" /idTUdmin="U1069" /TUdmin="-3629" /isTUend="FALSE" /label="downshifts" misc_RNA complement(1304067..1304179) /gene="tswB" /locus_tag="BSU_misc_RNA_19" /product="thiamine pyrophosphate riboswitch" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11470904, 12410317, 15862294, 16728979, 16962976, 17307816, 18179415, 18776013; Product type n: RNA" /function="16.3: Control" /label="tswB RNA" gene complement(1304067..1304179) /gene="tswB" /locus_tag="BSU_misc_RNA_19" /label="tswB gene" promotor_-35 1304180..1304183 /Source="Nicolas_upshift_promotors" /id="U1068" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.425574425574426" /psig="0.987012987012987" /xcortree=1848 /SigmaFactorBS="tcagccaaaacagcacccctagtgctttccGTATacaatttt ttattttGACATCATAATAGATGATAAgaatcattttgtaaacaacgaaatcattttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1304194..1304213) /Source="Nicolas_upshift_promotors" /id="U1069" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.917082917082917" /psig=1 /xcortree=2882 /SigmaFactorBS="accatcctctcccgtccctatatgaaaaaaatgatttcgtTG TTTACAaaatgattcttatcATCTATTATGATGTCAAAATaaaaaattgtatacggaa a" /listShort="NA, thiU, thiV, thiW, thiX" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 1304199..1304218 /Source="Nicolas_upshift_promotors" /id="U1068" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.425574425574426" /psig="0.987012987012987" /xcortree=1848 /SigmaFactorBS="tcagccaaaacagcacccctagtgctttccGTATacaatttt ttattttGACATCATAATAGATGATAAgaatcattttgtaaacaacgaaatcattttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1304210 /Source="Nicolas_upshifts" /id="U1068" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.425574425574426" /psig="0.987012987012987" /xcortree=1848 /SigmaFactorBS="tcagccaaaacagcacccctagtgctttccGTATacaatttt ttattttGACATCATAATAGATGATAAgaatcattttgtaaacaacgaaatcattttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1304215) /Source="Nicolas_upshifts" /id="U1069" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.917082917082917" /psig=1 /xcortree=2882 /SigmaFactorBS="accatcctctcccgtccctatatgaaaaaaatgatttcgtTG TTTACAaaatgattcttatcATCTATTATGATGTCAAAATaaaaaattgtatacggaa a" /listShort="NA, thiU, thiV, thiW, thiX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1304228..1304235) /Source="Nicolas_upshift_promotors" /id="U1069" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.917082917082917" /psig=1 /xcortree=2882 /SigmaFactorBS="accatcctctcccgtccctatatgaaaaaaatgatttcgtTG TTTACAaaatgattcttatcATCTATTATGATGTCAAAATaaaaaattgtatacggaa a" /listShort="NA, thiU, thiV, thiW, thiX" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1304281..1304967 /gene="ykoG" /locus_tag="BSU_13250" /old_locus_tag="BSU13250" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YkoH]" /protein_id="NP_389208.1" /db_xref="EnsemblGenomes-Gn:BSU13250" /db_xref="EnsemblGenomes-Tr:CAB13182" /db_xref="GOA:O34903" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG13252" /db_xref="UniProtKB/Swiss-Prot:O34903" /translation="MEKGHILIVEDEEKIARVLQLELEYEGYSVTIKHNGTEGLDAAA EGGYSLVLLDVMLPGLSGLEVLRRLRKTDSQTPVILLTARDSIPDKVTGLDIGANDYV TKPFEIEELLARIRAALRQNGTKTEDIGTFLTYDDLRVNEKTREVRRGDKEVELTPRE FDLLVYMLKHPQQVLTREQILSSVWGFDYIGDTNVVDVYIRYIRKKLDYPYEKQLIHT IRGVGYAIKG*" /label="ykoG CDS" gene 1304281..1304967 /gene="ykoG" /locus_tag="BSU_13250" /old_locus_tag="BSU13250" /label="ykoG gene" CDS 1304971..1306335 /gene="ykoH" /locus_tag="BSU_13260" /old_locus_tag="BSU13260" /EC_number="2.7.13.3" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YkoG]" /protein_id="NP_389209.1" /db_xref="EnsemblGenomes-Gn:BSU13260" /db_xref="EnsemblGenomes-Tr:CAB13183" /db_xref="GOA:O34638" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG13253" /db_xref="UniProtKB/Swiss-Prot:O34638" /translation="MKLKTKIHLYTSISLLILLILVHTAVYLIFSSALTSKDAARLAD ETDNIAEALRAAETEGVALQDMLQAYLPANGMVRVVNGDQKAVMTITKEKAYKDFPLS FHSGETADVRKPDGKLFAEAAVPVIWTDGQVVSLQLVERLENTEESLFLLKIILIAAS AAVCIASFFAGSLLARRIINPIRRLMITMKDIQRDKEFKTISLEGQSNDELYQMGLTF NEMAMMLKEHYDKQQQFVQDASHELKTPLTIIESYSSLMKRWGAKKPEVLEESIEAIH SEAVHMKKLTNQLLALAKSHQGLEVDLKTIDLIKAARAVMQTLQSVYQRDILLETDKE SLLVKADEERIKQLLTILLDNAIKYSEKPIEMSAGTRNGRPFLSVRDEGIGIPEEHIP HLFERFYRADEARNRKTGGTGLGLSIAKQIADEHGIELSVKSKPGQGTAVTMQFSEQN GGGR*" /label="ykoH CDS" gene 1304971..1306335 /gene="ykoH" /locus_tag="BSU_13260" /old_locus_tag="BSU13260" /label="ykoH gene" CDS 1306332..1307012 /gene="ykoI" /locus_tag="BSU_13270" /old_locus_tag="BSU13270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11717295; Product type m : membranecomponent" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_389210.1" /db_xref="EnsemblGenomes-Gn:BSU13270" /db_xref="EnsemblGenomes-Tr:CAB13184" /db_xref="GOA:O34551" /db_xref="InterPro:IPR014722" /db_xref="InterPro:IPR025711" /db_xref="SubtiList:BG13254" /db_xref="UniProtKB/Swiss-Prot:O34551" /translation="MTKTIKTVSFAAAAILVVIICTFLIIRQTHENVLSKETVVKKVE ASYEGKVTKATQSKDKKTYDITLENPKGTYFVKADAISADILSMNRVKAVNPSAMTEK EAEHLALERVPGTVKKQTRQSQVATYTIQKEDGKTYEVKVDMQAKTVLSADQISSKDQ QKTPITKKEAKTIAERKTGGTADDADLEESEGTLIFEVDVDLPDNKEATVKINAYTGK VANIVYED*" /label="ykoI CDS" gene 1306332..1307012 /gene="ykoI" /locus_tag="BSU_13270" /old_locus_tag="BSU13270" /label="ykoI gene" promotor_-35 1307041..1307046 /Source="Nicolas_upshift_promotors" /id="U1070" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.352647352647353" /psig="0.748251748251748" /xcortree=658 /SigmaFactorBS="aagactgacggtttctcatcaaattctcatcttgctCTCGTT ttcctttcatgttgaGTATGTAAACTGTACTCATacaaaacaaaggagggctcacaaa t" /listShort="ykoJ, ykzD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1307062..1307080 /Source="Nicolas_upshift_promotors" /id="U1070" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.352647352647353" /psig="0.748251748251748" /xcortree=658 /SigmaFactorBS="aagactgacggtttctcatcaaattctcatcttgctCTCGTT ttcctttcatgttgaGTATGTAAACTGTACTCATacaaaacaaaggagggctcacaaa t" /listShort="ykoJ, ykzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1307065 /Source="Nicolas_upshifts" /id="U1070" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.352647352647353" /psig="0.748251748251748" /xcortree=658 /SigmaFactorBS="aagactgacggtttctcatcaaattctcatcttgctCTCGTT ttcctttcatgttgaGTATGTAAACTGTACTCATacaaaacaaaggagggctcacaaa t" /listShort="ykoJ, ykzD" /GFF_Attribute="listLong" /label="upshifts" CDS 1307104..1307616 /gene="ykoJ" /locus_tag="BSU_13280" /old_locus_tag="BSU13280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17209068; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_389211.1" /db_xref="EnsemblGenomes-Gn:BSU13280" /db_xref="EnsemblGenomes-Tr:CAB13185" /db_xref="InterPro:IPR025711" /db_xref="SubtiList:BG13255" /db_xref="UniProtKB/Swiss-Prot:O35012" /translation="MLKKKWMVGLLAGCLAAGGFSYNAFATENNENRQASSKTDALTE QEAEAIAKTVVDGTVEDIDRDLYNGKEVYEVEIEKEGEDYDVYVDIHTKQALNDPLKE KAEQVAITKEEAEEIALKQTGGTVTESKLDEDDGAYIYEMEIQTKQGTETEFEISAKD GRIIKQEIDD*" /label="ykoJ CDS" gene 1307104..1307616 /gene="ykoJ" /locus_tag="BSU_13280" /old_locus_tag="BSU13280" /label="ykoJ gene" downshifts 1307602 /Source="Nicolas_upshifts" /id="D727" /incds=0 /nref=52 /ntot=228 /MaxReadThrough="3.74302" /MaxDrop="6.03059" /score="28.1760649" /energy="-13.7" /TU="U1070" /idTUdmin="U1070" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" promotor_-35 1307647..1307653 /Source="Nicolas_upshift_promotors" /id="U1071" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=922 /SigmaFactorBS="gatgactaatcaaaacccccgctgcagcgggggtttttcATG ATAAgaaaccttcttttGGACAATCTAAGtagaaaaggaggcgaaacgcatggaaaag a" /listShort="ykzD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1307667..1307678 /Source="Nicolas_upshift_promotors" /id="U1071" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=922 /SigmaFactorBS="gatgactaatcaaaacccccgctgcagcgggggtttttcATG ATAAgaaaccttcttttGGACAATCTAAGtagaaaaggaggcgaaacgcatggaaaag a" /listShort="ykzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1307668 /Source="Nicolas_upshifts" /id="U1071" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=922 /SigmaFactorBS="gatgactaatcaaaacccccgctgcagcgggggtttttcATG ATAAgaaaccttcttttGGACAATCTAAGtagaaaaggaggcgaaacgcatggaaaag a" /listShort="ykzD" /GFF_Attribute="listLong" /label="upshifts" CDS 1307699..1307836 /gene="ykzD" /locus_tag="BSU_13290" /old_locus_tag="BSU13290" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389212.1" /db_xref="EnsemblGenomes-Gn:BSU13290" /db_xref="EnsemblGenomes-Tr:CAB13186" /db_xref="InterPro:IPR022608" /db_xref="SubtiList:BG13332" /db_xref="UniProtKB/Swiss-Prot:O34405" /translation="MEKKEEQYINQAEYVPHPTKEGEYALFLHETYHLLSEDDETQTT E*" /label="ykzD CDS" gene 1307699..1307836 /gene="ykzD" /locus_tag="BSU_13290" /old_locus_tag="BSU13290" /label="ykzD gene" downshifts 1307809 /Source="Nicolas_upshifts" /id="D728" /incds=0 /nref=7 /ntot=31 /MaxReadThrough="1.81189" /MaxDrop="3.56977" /score="-4.52149284" /energy="-5.9" /TU="NA" /idTUdmin="U1070" /TUdmin=9 /isTUend="TRUE" /label="downshifts" promotor_-35 1307895..1307902 /Source="Nicolas_upshift_promotors" /id="U1072" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=2735 /SigmaFactorBS="tccgtaattgtgatgtaagcgcatttattacttttttGAGTT GACatagcttgtttttTTCTGTAATCTCAGTGTGTCaattcaattaggaacttcgtta g" /listShort="S473, S474, mgtE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1307916..1307935 /Source="Nicolas_upshift_promotors" /id="U1072" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=2735 /SigmaFactorBS="tccgtaattgtgatgtaagcgcatttattacttttttGAGTT GACatagcttgtttttTTCTGTAATCTCAGTGTGTCaattcaattaggaacttcgtta g" /listShort="S473, S474, mgtE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1307918..1308237 /Source="Nicolas_S_feature" /locus_tag="new_1395590_1395909" /HighExp="LBGstat, LBGtran, M40t45, MG 25, Mt0, Salt, MG 45, LPhT, BMM, MG t5" /AntisenseName="ykzO" /AntisenseCor="-0.16301119751811899" /AntisenseRegPval="-2.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S473" upshifts 1307918 /Source="Nicolas_upshifts" /id="U1072" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=2735 /SigmaFactorBS="tccgtaattgtgatgtaagcgcatttattacttttttGAGTT GACatagcttgtttttTTCTGTAATCTCAGTGTGTCaattcaattaggaacttcgtta g" /listShort="S473, S474, mgtE" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 1307950..1308103 /gene="swmG" /locus_tag="BSU_misc_RNA_68" /product="magnesium riboswitch" /experiment="publication(s) with functional evidences, PMID:15096624, 17803910, 21315082, 28455443" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15096624, 17803910, 21315082, 28455443; Product type n: RNA" /function="16.12: Sense" /function="16.3: Control" /label="swmG RNA" gene 1307950..1308103 /gene="swmG" /locus_tag="BSU_misc_RNA_68" /label="swmG gene" promotor_-35 1308215..1308224 /Source="Nicolas_upshift_promotors" /id="U1073" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=1632 /SigmaFactorBS="ccaatcaaaggaggtgcggagtatggattctccccaTTCGAG TCAAtctgaagaagtaCCCATATACTATGACAGCAAgacaattgattacacgatgagg a" /listShort="S474, mgtE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1308237..1308256 /Source="Nicolas_upshift_promotors" /id="U1073" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=1632 /SigmaFactorBS="ccaatcaaaggaggtgcggagtatggattctccccaTTCGAG TCAAtctgaagaagtaCCCATATACTATGACAGCAAgacaattgattacacgatgagg a" /listShort="S474, mgtE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1308239..1308340 /Source="Nicolas_S_feature" /locus_tag="new_1395911_1396012" /HighExp="LBGstat, LBGtran, M40t45, Mt0, LPhT, Paraq, MG t5, MG 25, MG 60, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99773400000000001" /TUshortSig="SigK, SigA" /TUshortPSig="0.876, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S474" upshifts 1308239 /Source="Nicolas_upshifts" /id="U1073" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=1632 /SigmaFactorBS="ccaatcaaaggaggtgcggagtatggattctccccaTTCGAG TCAAtctgaagaagtaCCCATATACTATGACAGCAAgacaattgattacacgatgagg a" /listShort="S474, mgtE" /GFF_Attribute="listLong" /label="upshifts" CDS 1308341..1309696 /gene="mgtE" /locus_tag="BSU_13300" /old_locus_tag="BSU13300" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15096624, 22970223, 24415722, 24968120, 25182490" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15096624, 22970223, 24415722, 24968120, 25182490; Product type t : transporter" /codon_start=1 /transl_table=11 /product="magnesium transporter" /protein_id="NP_389213.1" /db_xref="EnsemblGenomes-Gn:BSU13300" /db_xref="EnsemblGenomes-Tr:CAB13187" /db_xref="GOA:O34442" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR006667" /db_xref="InterPro:IPR006668" /db_xref="InterPro:IPR006669" /db_xref="InterPro:IPR036739" /db_xref="SubtiList:BG13256" /db_xref="UniProtKB/Swiss-Prot:O34442" /translation="MVQNMTYDELILRIIILLRDGKIRDFRSVIDELQPYDMAFIFKE MPEKHRARYLSYLTVDDITDMIGELEREFQLVVLNKVGKTKATLAMNKMDNDDLAQLL EEMDEELKEQLLSSMEASESKAVQLLMNYPADSAGRMMTNRYVWIPQHYTVKDAVVKL KSFAEIAESINYLYVINESKQLVGVLSYRDLILGEPEEKVQDLMFTRVISADALQDQE EVARLIERYDFLAIPVVEENNVLVGIVTVDDIIDVVIREADEDYEKFAASGKDITFDT KAYVAAYRRLPWLILLLFIGLISGSIISYFEDALKQVVALAFFMPMVSGMTGNTGTQS LAVVIRGLSKEEMNKKTIVRLIFREFRTSIFIGAVCSVLIAIVSIIWQGNALLGFVVA SSLFLTLIIGTMSGTIIPIILHKLKVDPAIASGPLITTLNDILSLLIYFGIATAFIHS L*" /label="mgtE CDS" gene 1308341..1309696 /gene="mgtE" /locus_tag="BSU_13300" /old_locus_tag="BSU13300" /label="mgtE gene" downshifts 1309687 /Source="Nicolas_upshifts" /id="D729" /incds=0 /nref=160 /ntot=239 /MaxReadThrough="1.02063" /MaxDrop="7.38933" /score="-4.14569718" /energy="-8.9" /TU="NA" /idTUdmin="U1072" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(1309739..1310071) /gene="tnrA" /locus_tag="BSU_13310" /old_locus_tag="BSU13310" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10231480, 12823818, 15916606, 16547045, 17085574, 17183219, 21435182, 23535029, 26635369" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10231480, 12823818, 15916606, 16547045, 17085574, 17183219, 21435182, 23535029, 26635369; Product type r: regulator" /codon_start=1 /transl_table=11 /product="nitrogen sensing transcriptional regulator" /protein_id="NP_389214.1" /db_xref="EnsemblGenomes-Gn:BSU13310" /db_xref="EnsemblGenomes-Tr:CAB13188" /db_xref="GOA:Q45666" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="PDB:4S0R" /db_xref="SubtiList:BG11805" /db_xref="UniProtKB/Swiss-Prot:Q45666" /translation="MTTEDHSYKDKKVISIGIVSELTGLSVRQIRYYEERKLIYPQRS SRGTRKYSFADVERLMDIANKREDGVQTAEILKDMRKKEQMLKNDPQVRKKMLEGQLN AHFRYKNR*" /label="tnrA CDS" gene complement(1309739..1310071) /gene="tnrA" /locus_tag="BSU_13310" /old_locus_tag="BSU13310" /label="tnrA gene" promotor_-10 complement(1310087..1310106) /Source="Nicolas_upshift_promotors" /id="U1074" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig="0.99100899100899" /xcortree=1709 /SigmaFactorBS="tttgatgttagaaaatatgacaagcgtcagGTTTTTtctctt tgttttttaTATACTATTATCAAAAGACAtccaggggtggaaaaatgaccacagaaga t" /listShort="tnrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1310097) /Source="Nicolas_upshifts" /id="U1074" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig="0.99100899100899" /xcortree=1709 /SigmaFactorBS="tttgatgttagaaaatatgacaagcgtcagGTTTTTtctctt tgttttttaTATACTATTATCAAAAGACAtccaggggtggaaaaatgaccacagaaga t" /listShort="tnrA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1310099..1310487) /Source="Nicolas_S_feature" /locus_tag="new_1397771_1398159_c" /HighExp="M9-stat, BC, LoTm, T1.30H, T0.30H, T2.0H, S8, C30, T4.0H, T2.30H" /AntisenseName="ykzB" /AntisenseCor="-3.3870578787867499E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.92" /TUlongSig="NA" /TUlongPSig="NA" /label="S475" promotor_-35 complement(1310122..1310127) /Source="Nicolas_upshift_promotors" /id="U1074" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig="0.99100899100899" /xcortree=1709 /SigmaFactorBS="tttgatgttagaaaatatgacaagcgtcagGTTTTTtctctt tgttttttaTATACTATTATCAAAAGACAtccaggggtggaaaaatgaccacagaaga t" /listShort="tnrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_no_box 1310159..1310259 /Source="Nicolas_upshift_promotors" /id="U1075" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.375624375624376" /psig="0.295704295704296" /xcortree=315 /SigmaFactorBS="agaagatttttgaaaaaatacggaagaaaaattaacaagaat aatgcgtaacacccaagcgcgttttatcctttatgtaacgaatcaaacgaggaggaag g" /listShort="ykzB, ykoL" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 1310219 /Source="Nicolas_upshifts" /id="U1075" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.375624375624376" /psig="0.295704295704296" /xcortree=315 /SigmaFactorBS="agaagatttttgaaaaaatacggaagaaaaattaacaagaat aatgcgtaacacccaagcgcgttttatcctttatgtaacgaatcaaacgaggaggaag g" /listShort="ykzB, ykoL" /GFF_Attribute="listLong" /label="upshifts" CDS 1310266..1310421 /gene="ykzB" /locus_tag="BSU_13320" /old_locus_tag="BSU13320" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 10671441" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389215.1" /db_xref="EnsemblGenomes-Gn:BSU13320" /db_xref="EnsemblGenomes-Tr:CAB13189" /db_xref="SubtiList:BG13330" /db_xref="UniProtKB/Swiss-Prot:O34923" /translation="MEEEKAVSLAKEIIELDIKRDEMLETFMQLAGEQAFQLLRSVQN GQYRKSS*" /label="ykzB CDS" gene 1310266..1310421 /gene="ykzB" /locus_tag="BSU_13320" /old_locus_tag="BSU13320" /label="ykzB gene" promotor_-35 1310430..1310437 /Source="Nicolas_upshift_promotors" /id="U1076" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.006993006993007" /xcortree=10 /SigmaFactorBS="caataccgaaaatcttcgtaaacataaatTCTTTACAttaga tTCATACCACGTTCATTTAaaaagagtatcttttgtataggatacctcaaaatgaagg a" /listShort="ykoL, S476, ykoM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1310444..1310461 /Source="Nicolas_upshift_promotors" /id="U1076" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.006993006993007" /xcortree=10 /SigmaFactorBS="caataccgaaaatcttcgtaaacataaatTCTTTACAttaga tTCATACCACGTTCATTTAaaaagagtatcttttgtataggatacctcaaaatgaagg a" /listShort="ykoL, S476, ykoM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1310461 /Source="Nicolas_upshifts" /id="U1076" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.006993006993007" /xcortree=10 /SigmaFactorBS="caataccgaaaatcttcgtaaacataaatTCTTTACAttaga tTCATACCACGTTCATTTAaaaagagtatcttttgtataggatacctcaaaatgaagg a" /listShort="ykoL, S476, ykoM" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1310472..1310491) /Source="Nicolas_upshift_promotors" /id="U1077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.394605394605395" /psig="0.92007992007992" /xcortree=3030 /SigmaFactorBS="tcgttctttttctaaagcggatttcaataaattactCATAGC GtcctccttcatttTGAGGTATCCTATACAAAAGatactctttttaaatgaacgtggt a" /listShort="S475, tnrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1310487) /Source="Nicolas_upshifts" /id="U1077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.394605394605395" /psig="0.92007992007992" /xcortree=3030 /SigmaFactorBS="tcgttctttttctaaagcggatttcaataaattactCATAGC GtcctccttcatttTGAGGTATCCTATACAAAAGatactctttttaaatgaacgtggt a" /listShort="S475, tnrA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1310505..1310511) /Source="Nicolas_upshift_promotors" /id="U1077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.394605394605395" /psig="0.92007992007992" /xcortree=3030 /SigmaFactorBS="tcgttctttttctaaagcggatttcaataaattactCATAGC GtcctccttcatttTGAGGTATCCTATACAAAAGatactctttttaaatgaacgtggt a" /listShort="S475, tnrA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1310509..1310691 /gene="ykoL" /locus_tag="BSU_13330" /old_locus_tag="BSU13330" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 10671441" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389216.1" /db_xref="EnsemblGenomes-Gn:BSU13330" /db_xref="EnsemblGenomes-Tr:CAB13190" /db_xref="SubtiList:BG13257" /db_xref="UniProtKB/Swiss-Prot:O34763" /translation="MSNLLKSALEKERRHYSEKLYQIGVYNKEVMNKMTISELRKEYA YFFRSITNHKNYPYTR*" /label="ykoL CDS" gene 1310509..1310691 /gene="ykoL" /locus_tag="BSU_13330" /old_locus_tag="BSU13330" /label="ykoL gene" downshifts 1310659 /Source="Nicolas_upshifts" /id="D730" /incds=0 /nref=2 /ntot=8 /MaxReadThrough="3.83398" /MaxDrop="4.6651" /score="19.6832496" /energy="-11.2" /TU="U1076" /idTUdmin="U1075" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1310716..1310724 /Source="Nicolas_upshift_promotors" /id="U1078" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=361 /SigmaFactorBS="atacaagataatgtataaggatttttttgcttttaGAAGGAA TTtctcgaattaTAGCGAATACGTATAGTAAgggactgaactcttattatatgtaagg g" /listShort="S476, ykoM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1310735..1310753 /Source="Nicolas_upshift_promotors" /id="U1078" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=361 /SigmaFactorBS="atacaagataatgtataaggatttttttgcttttaGAAGGAA TTtctcgaattaTAGCGAATACGTATAGTAAgggactgaactcttattatatgtaagg g" /listShort="S476, ykoM" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1310741..1310823 /Source="Nicolas_S_feature" /locus_tag="new_1398413_1398495" /HighExp="T3.0H, M9-stat, T1.30H, T2.30H, Lbstat, T3.30H, Lbtran, S2, T4.0H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH, Sig-" /TUshortPSig="0.996, 0.00699" /TUlongSig="NA" /TUlongPSig="NA" /label="S476" upshifts 1310741 /Source="Nicolas_upshifts" /id="U1078" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=361 /SigmaFactorBS="atacaagataatgtataaggatttttttgcttttaGAAGGAA TTtctcgaattaTAGCGAATACGTATAGTAAgggactgaactcttattatatgtaagg g" /listShort="S476, ykoM" /GFF_Attribute="listLong" /label="upshifts" CDS 1310824..1311288 /gene="ykoM" /locus_tag="BSU_13340" /old_locus_tag="BSU13340" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)" /protein_id="NP_389217.1" /db_xref="EnsemblGenomes-Gn:BSU13340" /db_xref="EnsemblGenomes-Tr:CAB13191" /db_xref="GOA:O34949" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13258" /db_xref="UniProtKB/Swiss-Prot:O34949" /translation="MMRLSFNEEEVERAMNLYRVFARAFKSVSEHSIRDSKEHGFNPT EFAVLELLYTRGPQKLQQIGSRLLLVSGNVTYVIDKLERNGFLVREQDPKDKRSVYAH LTDKGNEYLDKIYPIHALRIARAFSGLSPDEQDQLIVLLKKAGIHSQHLLFR*" /label="ykoM CDS" gene 1310824..1311288 /gene="ykoM" /locus_tag="BSU_13340" /old_locus_tag="BSU13340" /label="ykoM gene" downshifts 1311273 /Source="Nicolas_upshifts" /id="D731" /incds=0 /nref=70 /ntot=210 /MaxReadThrough="2.86787" /MaxDrop="5.38705" /score="24.8730632" /energy="-9.8" /TU="U1078" /idTUdmin="U1078" /TUdmin="-112" /isTUend="FALSE" /label="downshifts" CDS complement(1311303..1312424) /gene="ykoN" /locus_tag="BSU_13350" /old_locus_tag="BSU13350" /EC_number="2.4.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_389218.2" /db_xref="EnsemblGenomes-Gn:BSU13350" /db_xref="EnsemblGenomes-Tr:CAB13192" /db_xref="GOA:C0SPB9" /db_xref="InterPro:IPR009695" /db_xref="SubtiList:BG13259" /db_xref="UniProtKB/Swiss-Prot:C0SPB9" /translation="MKNILIFPFLSISTGHHHVADALQAELESQGLAAEKIDIFSHSY RRLEKLSSVAYLKWIQYFPKTYSGIYRLLACGEFQHDKRYFMYEWLFTQQMRHILQEK QPDIAFCTHALPSYLLNRLKPEYPNLTVVNVYTDFFVNQLWGRKNIDYHFVPSTEVKK QLISEGIDQNNIYLTGIPVHQNFEMESADTLQHHPPYTIIITGGSMGVGGILKWVQEL SPGGKILYKILCGRNEKLYSYVKSLHHPLIEAIPYLHSKAEMNRLYEQATGIMTKPGG VTISECLQKRLPVFIYHALPGQEEMNLNLLHERKLVTDMRNWDMQKAEEYIAAFFQSN EQMKEYKKHVNGYLGEMSDRKIKDVLKRIIWKQKNTLLK*" /label="ykoN CDS" gene complement(1311303..1312424) /gene="ykoN" /locus_tag="BSU_13350" /old_locus_tag="BSU13350" /label="ykoN gene" promotor_-35 1311712..1311720 /Source="Nicolas_upshift_promotors" /id="U1079" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=1311 /SigmaFactorBS="cctcaatcaaggggtggtgtaaacttttgacatagGAGTAGA GCttttcgtttctgcCGCATAATATTTTGTATAAGatctttccgcctggcgacagttc c" /listShort="S477, ykoP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1311734..1311753 /Source="Nicolas_upshift_promotors" /id="U1079" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=1311 /SigmaFactorBS="cctcaatcaaggggtggtgtaaacttttgacatagGAGTAGA GCttttcgtttctgcCGCATAATATTTTGTATAAGatctttccgcctggcgacagttc c" /listShort="S477, ykoP" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1311737..1312515 /Source="Nicolas_S_feature" /locus_tag="new_1399409_1400187" /HighExp="S6, S8, S7, S5, BT, B36, S4, S3, Pyr, G/S" /AntisenseName="ykoN" /AntisenseCor="0.84084970563549499" /AntisenseRegPval="-72.400000000000006" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.979" /TUlongSig="NA" /TUlongPSig="NA" /label="S477" upshifts 1311737 /Source="Nicolas_upshifts" /id="U1079" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=1311 /SigmaFactorBS="cctcaatcaaggggtggtgtaaacttttgacatagGAGTAGA GCttttcgtttctgcCGCATAATATTTTGTATAAGatctttccgcctggcgacagttc c" /listShort="S477, ykoP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1312453..1312464) /Source="Nicolas_upshift_promotors" /id="U1080" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=819 /SigmaFactorBS="aaggaaacaagttttcatcttttcaccttccttatgatcaaa aacaccCTTATATtttgtgaacgttctCCTCAAAATATAgttgccatatttttttagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1312473) /Source="Nicolas_upshifts" /id="U1080" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=819 /SigmaFactorBS="aaggaaacaagttttcatcttttcaccttccttatgatcaaa aacaccCTTATATtttgtgaacgttctCCTCAAAATATAgttgccatatttttttagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1312479..1312485) /Source="Nicolas_upshift_promotors" /id="U1080" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=819 /SigmaFactorBS="aaggaaacaagttttcatcttttcaccttccttatgatcaaa aacaccCTTATATtttgtgaacgttctCCTCAAAATATAgttgccatatttttttagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1312516..1313067 /gene="ykoP" /locus_tag="BSU_13360" /old_locus_tag="BSU13360" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389219.2" /db_xref="EnsemblGenomes-Gn:BSU13360" /db_xref="EnsemblGenomes-Tr:CAB13193" /db_xref="SubtiList:BG13260" /db_xref="UniProtKB/Swiss-Prot:O34495" /translation="MKTCFLSIWRVVDPIYFFFSRLSLIDNDQKSVFRVRLTKYKGHH VVLSDGTHIRKNDVLVKIHLHNIKLIRELQSIESAVRKGIIIYQKVYQSMPLLLDYIN NHKKSEKIKGIIGITMLDKGVERLGFDVITPVNPFYRCFKKVSHVPILYLTSKPVSLR HLPNSSYLFISKEKLQKTYQKKD*" /label="ykoP CDS" gene 1312516..1313067 /gene="ykoP" /locus_tag="BSU_13360" /old_locus_tag="BSU13360" /label="ykoP gene" downshifts 1313035 /Source="Nicolas_upshifts" /id="D732" /incds=0 /nref=4 /ntot=25 /MaxReadThrough="3.31887" /MaxDrop="3.7149" /score="-2.92393792" /energy="-7" /TU="U1079" /idTUdmin="U1079" /TUdmin="-242" /isTUend="FALSE" /label="downshifts" CDS complement(1313095..1313907) /gene="ykoQ" /locus_tag="BSU_13370" /old_locus_tag="BSU13370" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metallophosphoesterase" /protein_id="NP_389220.1" /db_xref="EnsemblGenomes-Gn:BSU13370" /db_xref="EnsemblGenomes-Tr:CAB13194" /db_xref="GOA:O35040" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG13261" /db_xref="UniProtKB/Swiss-Prot:O35040" /translation="MFTILLSLAILVFVPFLYKANRNTKDVKVNTISIDQKDGLPARK KLNILHLSDLHLENISVSPEELYHLTKDQPVDIIALTGDFLDRKRNIPKLAGYLNALQ KLKPAYGMYAVFGNHDYVLKEEDFQRLKRVLEENGCITLQNEHVRIETAAGPVNIIGI DDYSTNRSNITGSYQSLENGYHLVLTHDPNIILDMKDVHYDYLLSGHFHGGQIHWPKP YHLVKMGKLVRMNMIKGLHYHHDKPFYISEGLGQTGVNIRVGSRPEVTFHQI*" /label="ykoQ CDS" gene complement(1313095..1313907) /gene="ykoQ" /locus_tag="BSU_13370" /old_locus_tag="BSU13370" /label="ykoQ gene" promotor_-10 complement(1313867..1313886) /Source="Nicolas_upshift_promotors" /id="U1081" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.485514485514486" /psig="0.997002997002997" /xcortree=2484 /SigmaFactorBS="acttactatactgatagaagggaggggatatattttGTTTAC aatcttactttcaTTGGCCATACTCGTATTTGTgccatttctatataaagcgaaccgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1313881) /Source="Nicolas_upshifts" /id="U1081" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.485514485514486" /psig="0.997002997002997" /xcortree=2484 /SigmaFactorBS="acttactatactgatagaagggaggggatatattttGTTTAC aatcttactttcaTTGGCCATACTCGTATTTGTgccatttctatataaagcgaaccgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1313900..1313905) /Source="Nicolas_upshift_promotors" /id="U1081" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.485514485514486" /psig="0.997002997002997" /xcortree=2484 /SigmaFactorBS="acttactatactgatagaagggaggggatatattttGTTTAC aatcttactttcaTTGGCCATACTCGTATTTGTgccatttctatataaagcgaaccgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1314008..1314014 /Source="Nicolas_upshift_promotors" /id="U1082" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=939 /SigmaFactorBS="aattaatgggtagagacaggttgaaaaacggattgtcatatg aTGAATGAtttggaagggaaaAGGGATAATAAAttttgacacatgaggcagaacatgc c" /listShort="S478, ykoS, ykoT" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1314025..1314099 /Source="Nicolas_S_feature" /locus_tag="new_1401697_1401771" /HighExp="S5, S6, S7, S4, S8, T5.0H, ferm, nit, S3, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S478" upshifts 1314025 /Source="Nicolas_upshifts" /id="U1082" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=939 /SigmaFactorBS="aattaatgggtagagacaggttgaaaaacggattgtcatatg aTGAATGAtttggaagggaaaAGGGATAATAAAttttgacacatgaggcagaacatgc c" /listShort="S478, ykoS, ykoT" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1314028..1314039 /Source="Nicolas_upshift_promotors" /id="U1082" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=939 /SigmaFactorBS="aattaatgggtagagacaggttgaaaaacggattgtcatatg aTGAATGAtttggaagggaaaAGGGATAATAAAttttgacacatgaggcagaacatgc c" /listShort="S478, ykoS, ykoT" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1314100..1315794 /gene="ykoS" /locus_tag="BSU_13380" /old_locus_tag="BSU13380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_389221.1" /db_xref="EnsemblGenomes-Gn:BSU13380" /db_xref="EnsemblGenomes-Tr:CAB13195" /db_xref="GOA:O34830" /db_xref="SubtiList:BG13262" /db_xref="UniProtKB/Swiss-Prot:O34830" /translation="MLRLMRQQKKETYYLWIALFLLLLYVSPLFILKEDAHIRVHDNL DSNIAWYKVLADSGEIVGKVDAAIPQIINGLPRDAFGTEWSGIVWLHAFFSSMTAYAI SQTVTRVVAFFGMYVLLKKHIIPEPKAAFIRIGVSLAFALTPFWPSGMLSTLGYPLAL WAFLNIRKGDISWREWLTLGLLPLYSSFVLGFFFFLAGMACFWLYDAITKRRWNLMFL GSIAFMTSIYLFVEYRLVYSMLFEHAPMHRIEFISSRHDVWHSLRLSIKNFVYGHNHV MTVHTVVILPILMVVFAALLFKRNRTKPENVYLFLCVLNYGLSLWYAFWFNKIWAVPK QKFAFLAEFNFARFHFLRPLVIYVSFALALYLIWRMGKGWKWLVYAAVAAQLMVLAPF NEEYTYGVHYNAPTFREFYASEQFKEIKEYIGRPQDSYRVASIGLHPSIAQYNGFYTL DTYNNLYPLSYKYEFRKIIEKELEKNSRLKQYFDEWGSRCYLFVDELGKRYDFKKNSK KTINNLQLNTDVFKKMGGRYIFSSVPIMNAEQNHLALVKTFDHKDSAWRIYLYETR*" /label="ykoS CDS" gene 1314100..1315794 /gene="ykoS" /locus_tag="BSU_13380" /old_locus_tag="BSU13380" /label="ykoS gene" CDS 1315807..1316820 /gene="ykoT" /locus_tag="BSU_13390" /old_locus_tag="BSU13390" /EC_number="2.-.-.-" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_389222.1" /db_xref="EnsemblGenomes-Gn:BSU13390" /db_xref="EnsemblGenomes-Tr:CAB13196" /db_xref="GOA:O34755" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG13263" /db_xref="UniProtKB/Swiss-Prot:O34755" /translation="MKQSQPVLTIVVPCFNEEEVFQETSHQLTEVVDDLIEEKLIAED SKILFVDDGSKDRTWALIAMESIRNKKVTGLKLACNVGHQKALLAGLHKAKNRSDCVI SIDADLQDDISVIRDFMLKYHEGCEIVYGVRRSRKTDTFFKRTTALGFYRLMNKLGIK LIYNHADFRLMNKRSLEELERYPEANLFLRGIVPMIGFKSAEVLYDRKERFAGKTKYP LKKMLSFAFNGITSFSVAPIRFFTLLGFVLFFLSAVAGIGAFIQKLLGHTNAGWASLI ISIWFLGGLQLMGIGIIGEYIGTIFSEVKRRPKYAIDIDLYNEQLSPLQRQEKERLEK KYS*" /label="ykoT CDS" gene 1315807..1316820 /gene="ykoT" /locus_tag="BSU_13390" /old_locus_tag="BSU13390" /label="ykoT gene" downshifts 1316805 /Source="Nicolas_upshifts" /id="D733" /incds=0 /nref=13 /ntot=35 /MaxReadThrough="0.53349" /MaxDrop="4.80671" /score="19.4012674" /energy="-13.7" /TU="NA" /idTUdmin="U1082" /TUdmin=8 /isTUend="TRUE" /label="downshifts" CDS complement(1316846..1318681) /gene="ligD" /locus_tag="BSU_13400" /old_locus_tag="BSU13400" /EC_number="6.5.1.1" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12215643, 16497325, 17293412, 23691176, 25355514, 26826709" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12215643, 16497325, 17293412, 23691176, 25355514, 26826709; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent DNA ligase subunit; 5'-2-deoxyribose-5-phosphate (dRP) lyase" /protein_id="NP_389223.1" /db_xref="EnsemblGenomes-Gn:BSU13400" /db_xref="EnsemblGenomes-Tr:CAB13197" /db_xref="GOA:O34398" /db_xref="InterPro:IPR012310" /db_xref="InterPro:IPR014143" /db_xref="InterPro:IPR014145" /db_xref="InterPro:IPR014146" /db_xref="InterPro:IPR033652" /db_xref="SubtiList:BG13264" /db_xref="UniProtKB/Swiss-Prot:O34398" /translation="MAFTMQPVLTSSPPIGAEWRYEVKYDGYRCILRIHSSGVTLTSR NGVELSSTFPEITQFAKTAFQHLEKELPLTLDGEIVCLVNPCRADFEHLQVRGRLKRP DKIQESANARPCCFLAFDLLERSGEDVTLLSYLDRKKSLRELISAAKLPASPDPYAKE TIQSIPCYDHFDQLWEMVIKYDGEGIVAKKTNSKWLEKKRSSDWLKYKNFKQAYVCIT GFNPNNGFLTVSVLKNGIMTPIASVSHGMRDEEKSAIREIMEQHGHQTPSGEFTLEPS ICAAVQYLTILQGTLREVSFIGFEFQMDWTECTYAQVIRHSKPVHPKLQFTSLDKIIF EKNKKTKEDFIQYMIEVSDYLLPFLKNRAVTVIRYPHGSRSESFFQKNKPDYAPDFVQ SFYDGSHEHIVCEDMSTLLWLCNQLALEFHVPFQTIKSRRPAEIVIDLDPPSRDDFLM AVQAANELKRLLDSFGITSYPKLSGNKGIQLYIPLSPEAFTYEETRQFTQLIAEYCTN AFPELFTTERLIKNRHCKLYLDYLQHAEGKTIICPYSTRGNELGTVAAPLYWHEVQSS LTPALFTIDTVIDRIKKQGCPFFDFYRNPQDEPLSAILHQLKKKS*" /label="ligD CDS" gene complement(1316846..1318681) /gene="ligD" /locus_tag="BSU_13400" /old_locus_tag="BSU13400" /label="ligD gene" downshifts complement(1316895) /Source="Nicolas_upshifts" /id="D734" /incds=0 /nref=10 /ntot=54 /MaxReadThrough="0.67916" /MaxDrop="5.08051" /score="-8.48510187" /energy="-13.7" /TU="NA" /idTUdmin="U1083" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1318685..1319620) /gene="ligV" /locus_tag="BSU_13410" /old_locus_tag="BSU13410" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11095673, 12215643, 16497325, 16780573, 23691176, 25355514" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11095673, 12215643, 16497325, 16780573, 23691176, 25355514; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent DNA ligase subunit Ku; AP/deoxyribose 5'-phosphate (5'-dRP)-lyase" /protein_id="NP_389224.1" /db_xref="EnsemblGenomes-Gn:BSU13410" /db_xref="EnsemblGenomes-Tr:CAB13198" /db_xref="GOA:O34859" /db_xref="InterPro:IPR006164" /db_xref="InterPro:IPR009187" /db_xref="InterPro:IPR016194" /db_xref="SubtiList:BG13265" /db_xref="UniProtKB/Swiss-Prot:O34859" /translation="MNRTPSLHTKEKKGFIDMHTMWKGSISFGLVNIPIKLYAATEDK DIKLRSLHKEDHAPIKYEKVCTNCEKTLSPDEIVKGYEYVKGKYVVLTDEDLKSLKQE HEEKAVEIVDFVQLQEIDPIYFNRSYFVGPGDNGTKAYTLLREALRSTGKIGIANMTI RSKQQLAILRVYENCIVMESIHYPDEVRSAAQVPGVPDQSNVNDKELQTAITLIDELT AKFEPEKYEDTYRQALLQRVNDKLENKETAVTPDKAPPREDVIDLVSALQASIDRTRR PNRETPAAAPAQAAEPKGAGDKKQKTTRKKASGTS*" /label="ligV CDS" gene complement(1318685..1319620) /gene="ligV" /locus_tag="BSU_13410" /old_locus_tag="BSU13410" /label="ligV gene" promotor_-10 complement(1319591..1319602) /Source="Nicolas_upshift_promotors" /id="U1083" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=856 /SigmaFactorBS="aataacagcgccggctttttttcacccataagttactaCACA TGAatcgtactccttctCTTCACACTAAAgaaaaaaaggggtttatcgatatgcatac a" /listShort="ykoV, ykoU" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1319601) /Source="Nicolas_upshifts" /id="U1083" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=856 /SigmaFactorBS="aataacagcgccggctttttttcacccataagttactaCACA TGAatcgtactccttctCTTCACACTAAAgaaaaaaaggggtttatcgatatgcatac a" /listShort="ykoV, ykoU" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1319617..1319623) /Source="Nicolas_upshift_promotors" /id="U1083" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=856 /SigmaFactorBS="aataacagcgccggctttttttcacccataagttactaCACA TGAatcgtactccttctCTTCACACTAAAgaaaaaaaggggtttatcgatatgcatac a" /listShort="ykoV, ykoU" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1319657..1322059) /gene="dgcW" /locus_tag="BSU_13420" /old_locus_tag="BSU13420" /EC_number="2.7.7.65" /function="16.3: Control" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11728710, 17010156, 23893111, 28536559" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11728710, 17010156, 23893111, 28536559; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="diguanylate cyclase" /protein_id="YP_054577.2" /db_xref="EnsemblGenomes-Gn:BSU13420" /db_xref="EnsemblGenomes-Tr:CAB13199" /db_xref="GOA:O34311" /db_xref="InterPro:IPR000160" /db_xref="InterPro:IPR001633" /db_xref="InterPro:IPR005330" /db_xref="InterPro:IPR029787" /db_xref="InterPro:IPR035919" /db_xref="InterPro:IPR035965" /db_xref="SubtiList:BG13266" /db_xref="UniProtKB/Swiss-Prot:O34311" /translation="MEIHVTYNTTLICLSILIACTASYISLELSRKVTINTGLKSKIW LIGGSLIMGFGIWSMHFVGMMAVHMEMPMEYEFMPLMAAIGASVSGSFVSLYFVSRHI LTYYRLLTGSVVLGASIASMHYIGMSAISRVMIIYEPILFTVSIIIAIAASFVSLKIF FDLAVKKHSEHLIFYKGVSSIVMGIGISGMHYTGMLAATFHKDMAPPGSHMEVQTFHW SIFVTLIIFCIQTLLLFSSHADRKFIKQSERIKDNEQRFQSLIVHNIDAIFILSLEGD IISSNHAGEEMISKFGFSMHDWRNYTSLKVKRLFEQVKKDKQAMNSDSDLITEKGQFH LNITLIPVEVNQELDSIYVICKDMTKQYKAEKEIHRMAHYDSLTDLPNRRHAISHLTK VLNREHSLHYNTVVFFLDLNRFKVINDALGHNVGDQLLQFAAKRLSSVVPDNGFIARL GGDEFIIILTDANTGTGEADVLARKIIQKFKKPFKIQDHTLVTSVSIGIAISPKDGTD GLELMKKADMAMYAAKERNKSKYRYYSFSIGNKETVKLNQEMVLREAIENDRFVLHYQ PQFSVKKQKMTGAEALIRLVTPDGQLRPPGEFIGVAEETGLIIDIGKWIIDEACKQAR IWHDKGYDLSVAINISARQFQSKDLIPLIKDTLNKYQLPPQLLEVEVTESMTMDNLNH SKKVLSSLTELGIRISIDDFGTGHSSLSYLKDFPIHRLKIDKSFIDDIQTHPKSEQIT GAIIAMGHQLSLQVIAEGVENAAQKQLLFEKGCDHLQGFFFSRPIPPEQFEQFIIEQP SQ*" /label="dgcW CDS" gene complement(1319657..1322059) /gene="dgcW" /locus_tag="BSU_13420" /old_locus_tag="BSU13420" /label="dgcW gene" downshifts complement(1319689) /Source="Nicolas_upshifts" /id="D735" /incds=0 /nref=13 /ntot=101 /MaxReadThrough="1.93589" /MaxDrop="3.26543" /score="6.55794882" /energy="-9" /TU="NA" /idTUdmin="U1084" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1321907..1322109) /Source="Nicolas_S_feature" /locus_tag="new_1409579_1409781_c" /HighExp="Cold, GM 25, GM 10, GM 45, GM 15, GM-0.2, GM-0.1, GM 5, GM 90, Glu" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S479" promotor_-10 complement(1322098..1322116) /Source="Nicolas_upshift_promotors" /id="U1084" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2819 /SigmaFactorBS="agatctccctcgtatttctatcgttttgaaggCTGAAACTct gcggttaagcaGCCGATAATAAAGAGAGTCaacaagactggaacacacgatacggggg g" /listShort="S479, ykoW" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1322109) /Source="Nicolas_upshifts" /id="U1084" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2819 /SigmaFactorBS="agatctccctcgtatttctatcgttttgaaggCTGAAACTct gcggttaagcaGCCGATAATAAAGAGAGTCaacaagactggaacacacgatacggggg g" /listShort="S479, ykoW" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1322130..1322137) /Source="Nicolas_upshift_promotors" /id="U1084" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2819 /SigmaFactorBS="agatctccctcgtatttctatcgttttgaaggCTGAAACTct gcggttaagcaGCCGATAATAAAGAGAGTCaacaagactggaacacacgatacggggg g" /listShort="S479, ykoW" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1322176..1322183 /Source="Nicolas_upshift_promotors" /id="U1085" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.432567432567433" /psig="0.999000999001" /xcortree=1761 /SigmaFactorBS="atagaaatacgagggagatctatttttAGTTCAACtgaccgt gaaaaaTGTGTTAAAATCATCTTGATgttttccgaaaagagaaaaatgtatgatacat a" /listShort="ykoX, ykoY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1322197..1322216 /Source="Nicolas_upshift_promotors" /id="U1085" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.432567432567433" /psig="0.999000999001" /xcortree=1761 /SigmaFactorBS="atagaaatacgagggagatctatttttAGTTCAACtgaccgt gaaaaaTGTGTTAAAATCATCTTGATgttttccgaaaagagaaaaatgtatgatacat a" /listShort="ykoX, ykoY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1322209 /Source="Nicolas_upshifts" /id="U1085" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.432567432567433" /psig="0.999000999001" /xcortree=1761 /SigmaFactorBS="atagaaatacgagggagatctatttttAGTTCAACtgaccgt gaaaaaTGTGTTAAAATCATCTTGATgttttccgaaaagagaaaaatgtatgatacat a" /listShort="ykoX, ykoY" /GFF_Attribute="listLong" /label="upshifts" CDS 1322240..1322905 /gene="ykoX" /locus_tag="BSU_13430" /old_locus_tag="BSU13430" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 23687963; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_389226.1" /db_xref="EnsemblGenomes-Gn:BSU13430" /db_xref="EnsemblGenomes-Tr:CAB13200" /db_xref="GOA:O34908" /db_xref="InterPro:IPR032816" /db_xref="SubtiList:BG13267" /db_xref="UniProtKB/Swiss-Prot:O34908" /translation="MIHKHETRELVAIEELVMSWIEAFKSLSYFGIFLALSIEFIPAE VVLPLAGYWVSKGDMTLAGVVLAGSLGGVAGPLTLYWIGRYGGRPFLERFGKYLFIKP EALDKSDNFFKKHGGFVAFSGRFLPGIRTLISIPCGIAKMNVWVFSLYTFIAMLPITF VYVYLGVKLGENWKAVGSILDQYMLPIGIAILALFLLYLLMKKRKKRTHSEQLSVFLK NKR*" /label="ykoX CDS" gene 1322240..1322905 /gene="ykoX" /locus_tag="BSU_13430" /old_locus_tag="BSU13430" /label="ykoX gene" promotor_-10 complement(1322774..1322793) /Source="Nicolas_upshift_promotors" /id="U1086" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1257 /SigmaFactorBS="cctctttttcatcagtaagtagagcaggaacagcgCCAAAAT CGCtatcccgatcggaAGCATATATTGATCAAGAATagagccgactgccttccaattt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1322791) /Source="Nicolas_upshifts" /id="U1086" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1257 /SigmaFactorBS="cctctttttcatcagtaagtagagcaggaacagcgCCAAAAT CGCtatcccgatcggaAGCATATATTGATCAAGAATagagccgactgccttccaattt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1322807..1322816) /Source="Nicolas_upshift_promotors" /id="U1086" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1257 /SigmaFactorBS="cctctttttcatcagtaagtagagcaggaacagcgCCAAAAT CGCtatcccgatcggaAGCATATATTGATCAAGAATagagccgactgccttccaattt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1322900..1322907 /Source="Nicolas_upshift_promotors" /id="U1087" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.952047952047952" /psig=1 /xcortree=600 /SigmaFactorBS="attatctgtatttttgaaaaataaaCGTTGACAaatcactgc gctgcGCATATTATTGACGTATAAAatcatatttcttgaaatcccaaaggggagtagc g" /listShort="ykoY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1322922..1322941 /Source="Nicolas_upshift_promotors" /id="U1087" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.952047952047952" /psig=1 /xcortree=600 /SigmaFactorBS="attatctgtatttttgaaaaataaaCGTTGACAaatcactgc gctgcGCATATTATTGACGTATAAAatcatatttcttgaaatcccaaaggggagtagc g" /listShort="ykoY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1322935 /Source="Nicolas_upshifts" /id="U1087" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.952047952047952" /psig=1 /xcortree=600 /SigmaFactorBS="attatctgtatttttgaaaaataaaCGTTGACAaatcactgc gctgcGCATATTATTGACGTATAAAatcatatttcttgaaatcccaaaggggagtagc g" /listShort="ykoY" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 1322961..1323094 /gene="mnrW" /locus_tag="BSU_misc_RNA_87" /product="manganese ion riboswitch" /experiment="publication(s) with functional evidences, PMID:25794618, 25794619" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25794618, 25794619; Product type n: RNA" /function="16.12: Sense" /function="16.3: Control" /label="mnrW RNA" gene 1322961..1323094 /gene="mnrW" /locus_tag="BSU_misc_RNA_87" /label="mnrW gene" CDS 1322982..1323956 /gene="ykoY" /locus_tag="BSU_13440" /old_locus_tag="BSU13440" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15096624, 15849754, 16850406, 25794618, 25794619; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative manganese-related ion transporter" /protein_id="NP_389227.1" /db_xref="EnsemblGenomes-Gn:BSU13440" /db_xref="EnsemblGenomes-Tr:CAB13201" /db_xref="GOA:O34997" /db_xref="InterPro:IPR005496" /db_xref="InterPro:IPR022493" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13268" /db_xref="UniProtKB/Swiss-Prot:O34997" /translation="MYSGNKVVISWIVSIGFVGMPEFMSSKTFALCRQRSFLHGPAGI RSDEEKENNFFGRVSFMDAALLLEYGWVLLVLIGLEGILAADNALVMAVMVKHLPEEK RKKALFYGLAGAFVLRFGSLFAISFLVNVWQVQAIGAIYLLYISASHLLKRYVFKKED THKETKQSGFWPTVLKVELADIAFAVDSILAAVALAVTLPGTSLPKIGGLDGGQFLVI LAGGIIGLVIMRFAASMFVKLLKERPSLETAAFVIVGWVGVKLALYTLAHRDIAVVSE HFIHSGTWKLIFWGVLAAIAVCGWFMSGGKKQPEGAQNEQKNSTRERA*" /label="ykoY CDS" gene 1322982..1323956 /gene="ykoY" /locus_tag="BSU_13440" /old_locus_tag="BSU13440" /label="ykoY gene" downshifts 1323045 /Source="Nicolas_upshifts" /id="D736" /incds=1 /nref=38 /ntot=211 /MaxReadThrough="5.00041" /MaxDrop="4.46498" /score="15.8563987" /energy="-15" /TU="U1085,U1087" /idTUdmin="U1085" /TUdmin="-902" /isTUend="FALSE" /label="downshifts" downshifts 1323944 /Source="Nicolas_upshifts" /id="D737" /incds=0 /nref=16 /ntot=175 /MaxReadThrough="2.59801" /MaxDrop="4.20782" /score="24.4740487" /energy="-13.7" /TU="NA" /idTUdmin="U1085" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" promotor_-35 1324066..1324074 /Source="Nicolas_upshift_promotors" /id="U1088" /multdbtbs="SigI" /comp="M2" /sig="SigI" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1768 /SigmaFactorBS="atctttgttacaaaaaacacgcataaaaCCCCCTTAAttctt tagaaaggCACGAAATCatgtatagaacgtcagaatggtttgtcataattgagacatt g" /listShort="S480, sigI, rsgI, S481" /listLong="htpX" /label="promotor_-35" promotor_-10 1324088..1324096 /Source="Nicolas_upshift_promotors" /id="U1088" /multdbtbs="SigI" /comp="M2" /sig="SigI" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1768 /SigmaFactorBS="atctttgttacaaaaaacacgcataaaaCCCCCTTAAttctt tagaaaggCACGAAATCatgtatagaacgtcagaatggtttgtcataattgagacatt g" /listShort="S480, sigI, rsgI, S481" /listLong="htpX" /label="promotor_-10" upshifts 1324098 /Source="Nicolas_upshifts" /id="U1088" /multdbtbs="SigI" /comp="M2" /sig="SigI" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1768 /SigmaFactorBS="atctttgttacaaaaaacacgcataaaaCCCCCTTAAttctt tagaaaggCACGAAATCatgtatagaacgtcagaatggtttgtcataattgagacatt g" /listShort="S480, sigI, rsgI, S481" /listLong="htpX" /label="upshifts" S_feature 1324101..1324187 /Source="Nicolas_S_feature" /locus_tag="new_1411773_1411859" /HighExp="M9-stat, T1.30H, T1.0H, T0.30H, T2.0H, T2.30H, HiTm, M0t90, T3.0H, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.29969800000000002" /TUshortSig="SigI" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S480" promotor_-35 1324160..1324167 /Source="Nicolas_upshift_promotors" /id="U1089" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig=1 /xcortree=1635 /SigmaFactorBS="tgagacattggaaatcaatatttctttttctCCTTTGCGaat ccctatcaaaTTAGCTATCATTAATGAGTAgttatagggaggaactgaggtgaaacca g" /listShort="sigI, rsgI, S481" /listLong="htpX" /label="promotor_-35" promotor_-10 1324181..1324200 /Source="Nicolas_upshift_promotors" /id="U1089" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig=1 /xcortree=1635 /SigmaFactorBS="tgagacattggaaatcaatatttctttttctCCTTTGCGaat ccctatcaaaTTAGCTATCATTAATGAGTAgttatagggaggaactgaggtgaaacca g" /listShort="sigI, rsgI, S481" /listLong="htpX" /label="promotor_-10" upshifts 1324189 /Source="Nicolas_upshifts" /id="U1089" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig=1 /xcortree=1635 /SigmaFactorBS="tgagacattggaaatcaatatttctttttctCCTTTGCGaat ccctatcaaaTTAGCTATCATTAATGAGTAgttatagggaggaactgaggtgaaacca g" /listShort="sigI, rsgI, S481" /listLong="htpX" /label="upshifts" CDS 1324220..1324975 /gene="sigI" /locus_tag="BSU_13450" /old_locus_tag="BSU13450" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11157964, 12682299, 17185538, 18156261, 21541672, 24125693, 28333276" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11157964, 12682299, 17185538, 18156261, 21541672, 24125693, 28333276; Product type f: factor" /codon_start=1 /transl_table=11 /product="RNA polymerase sigma factor (heat stress responsive)" /protein_id="NP_389228.1" /db_xref="EnsemblGenomes-Gn:BSU13450" /db_xref="EnsemblGenomes-Tr:CAB13218" /db_xref="GOA:O31654" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014244" /db_xref="InterPro:IPR014284" /db_xref="SubtiList:BG13269" /db_xref="UniProtKB/Swiss-Prot:O31654" /translation="MKPVLSLLFKLGKKKQTLEKAVESIQKGNKDLQNELIQQYKPFI AKTVSSVCKRYIDEKDDEFSIGLIAFNEAIEKYSPEKGNSLLAFAELIIKRKVIDYIR KEARSAQNINIDLQEGDDQESSQSLIEAELSIDEYRRQIEQEQRREEILYFQKQLKDY GLSFKELLENSPKHTDARQNAIKVAMTLVEHEELAAILYTKKQLPVKQLEQLVSVSRK TIERNRKYIIAMCIIITGDYIYLKDYLKGVLHS*" /label="sigI CDS" gene 1324220..1324975 /gene="sigI" /locus_tag="BSU_13450" /old_locus_tag="BSU13450" /label="sigI gene" CDS 1324972..1326117 /gene="rsgI" /locus_tag="BSU_13460" /old_locus_tag="BSU13460" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17185538, 23199363, 28333276" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17185538, 23199363, 28333276; Product type f: factor" /codon_start=1 /transl_table=11 /product="sigmaI modulating factor" /protein_id="NP_389229.1" /db_xref="EnsemblGenomes-Gn:BSU13460" /db_xref="EnsemblGenomes-Tr:CAB13219" /db_xref="GOA:O31655" /db_xref="InterPro:IPR024449" /db_xref="SubtiList:BG13272" /db_xref="UniProtKB/Swiss-Prot:O31655" /translation="MRRGIIVEKNKKFVTLLTPDGQFLKAKNDRHSYEIGEEIMLPSE TRMGRRASFFDFFKLRPFKMGIFTMTAIMLFIFIVLPVFSNNKAYAYMTIDINPSVEM ALNSDYEVIELTPLNDEGQKVVNDIDDWEKTDFKKVIDDIITDCSEHGYVKKSKEILI STVYENTEDNTYKKAVKKQLNDVTEKYKTTYRMESLESDMQTREKAKKEGVSTGSYIK SNEKNDNKDIKDDSSKPSGEEDQKSDENEDENTDQTDTQDSKQGDNEQLNDADSGDQK EEKADDQIDDSDKDKKIKESDENTNTEKDGDHEQTPIQDPQDKGNENNGADKGQSQYH RDWNNGEQGKNRSSSRRDNASDRRNPNGYSSDNHSAKNEDSPSAPGE*" /label="rsgI CDS" gene 1324972..1326117 /gene="rsgI" /locus_tag="BSU_13460" /old_locus_tag="BSU13460" /label="rsgI gene" S_feature 1326118..1327277 /Source="Nicolas_S_feature" /locus_tag="new_1413790_1414949" /HighExp="HiTm, G135, G180, C30, G150, Cold, S8, MG 25, H2O2, Lbstat" /AntisenseName="ykrK" /AntisenseCor="0.122248209149143" /AntisenseRegPval="-1.3" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigI" /TUshortPSig="1, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S481" CDS complement(1326128..1326322) /gene="sspD" /locus_tag="BSU_13470" /old_locus_tag="BSU13470" /function="16.5: Explore" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:3009397, 3112127, 3121585, 9852018" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3009397, 3112127, 3121585, 9852018; Product type f: factor" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein (alpha/beta-type SASP)" /protein_id="NP_389230.1" /db_xref="EnsemblGenomes-Gn:BSU13470" /db_xref="EnsemblGenomes-Tr:CAB13220" /db_xref="GOA:P04833" /db_xref="InterPro:IPR001448" /db_xref="InterPro:IPR018126" /db_xref="SubtiList:BG10788" /db_xref="UniProtKB/Swiss-Prot:P04833" /translation="MASRNKLVVPGVEQALDQFKLEVAQEFGVNLGSDTVARANGSVG GEMTKRLVQQAQSQLNGTTK*" /label="sspD CDS" gene complement(1326128..1326322) /gene="sspD" /locus_tag="BSU_13470" /old_locus_tag="BSU13470" /label="sspD gene" downshifts complement(1326135) /Source="Nicolas_upshifts" /id="D738" /incds=0 /nref=24 /ntot=36 /MaxReadThrough="1.67859" /MaxDrop="4.68215" /score="41.3727153" /energy="-15.2" /TU="NA" /idTUdmin="U1090" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1326365..1326376) /Source="Nicolas_upshift_promotors" /id="U1090" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=868 /SigmaFactorBS="cagaggccggggttttatttttctccacaacaattgccAGCA TAAataaaccccgtataTTTCAAACTAAAtacgcgttaagaatttctttatcgaaaaa g" /listShort="sspD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1326375) /Source="Nicolas_upshifts" /id="U1090" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=868 /SigmaFactorBS="cagaggccggggttttatttttctccacaacaattgccAGCA TAAataaaccccgtataTTTCAAACTAAAtacgcgttaagaatttctttatcgaaaaa g" /listShort="sspD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1326391..1326397) /Source="Nicolas_upshift_promotors" /id="U1090" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=868 /SigmaFactorBS="cagaggccggggttttatttttctccacaacaattgccAGCA TAAataaaccccgtataTTTCAAACTAAAtacgcgttaagaatttctttatcgaaaaa g" /listShort="sspD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1326453..1327154) /gene="htpK" /locus_tag="BSU_13480" /old_locus_tag="BSU13480" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:22447908, 23042994" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22447908, 23042994; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of quality control" /protein_id="NP_389231.1" /db_xref="EnsemblGenomes-Gn:BSU13480" /db_xref="EnsemblGenomes-Tr:CAB13221" /db_xref="InterPro:IPR014975" /db_xref="SubtiList:BG13273" /db_xref="UniProtKB/Swiss-Prot:O31656" /translation="MNIFKLSRTDMVRLLYSLKGQGEHSPLDILVQSANMSAEKAANH LEIPEFLTRYERKKQKKEYGLSTNEIVELGNLCELTSLKSTAIQNWVKRDIKDLIGHP ELGKKYSIEQAVILLIVRDLKSIYDFEHIRAILKVAFNTISDRSDDVISPIAYYESCA YVLDAIHHQDTPSMKESNLQEIAEQETERLRHRFEELNDSQWLKIRQIIAITVLSILT FHIQATAHKMTADIL*" /label="htpK CDS" gene complement(1326453..1327154) /gene="htpK" /locus_tag="BSU_13480" /old_locus_tag="BSU13480" /label="htpK gene" downshifts complement(1326487) /Source="Nicolas_upshifts" /id="D739" /incds=0 /nref=174 /ntot=231 /MaxReadThrough="2.96889" /MaxDrop="5.30355" /score="41.3727153" /energy="-15.2" /TU="NA" /idTUdmin="U1091" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1327155..1327235) /Source="Nicolas_S_feature" /locus_tag="new_1414827_1414907_c" /HighExp="LBGtran, dia0, LBGexp, Lbexp, Oxctl, G180, M0t45, C90, Paraq, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S482" promotor_-10 complement(1327227..1327246) /Source="Nicolas_upshift_promotors" /id="U1091" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=2572 /SigmaFactorBS="aacccgtatatttaaattataaaacatcCATTTGAAaatgca aggaattCGACGTATGATGTTAATGTAatttgctgacgcttgaattttgaacttatac a" /listShort="S482, ykrK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1327235) /Source="Nicolas_upshifts" /id="U1091" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=2572 /SigmaFactorBS="aacccgtatatttaaattataaaacatcCATTTGAAaatgca aggaattCGACGTATGATGTTAATGTAatttgctgacgcttgaattttgaacttatac a" /listShort="S482, ykrK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1327251..1327258 /Source="Nicolas_upshift_promotors" /id="U1092" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.898101898101898" /psig=1 /xcortree=1759 /SigmaFactorBS="cagcaaattacattaacatcatacgtcgaattCCTTGCATtt tcaaatggatgTTTTATAATTTAAATATACGggttcttttgaacttaaaataacggag g" /listShort="htpX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(1327260..1327267) /Source="Nicolas_upshift_promotors" /id="U1091" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=2572 /SigmaFactorBS="aacccgtatatttaaattataaaacatcCATTTGAAaatgca aggaattCGACGTATGATGTTAATGTAatttgctgacgcttgaattttgaacttatac a" /listShort="S482, ykrK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1327272..1327291 /Source="Nicolas_upshift_promotors" /id="U1092" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.898101898101898" /psig=1 /xcortree=1759 /SigmaFactorBS="cagcaaattacattaacatcatacgtcgaattCCTTGCATtt tcaaatggatgTTTTATAATTTAAATATACGggttcttttgaacttaaaataacggag g" /listShort="htpX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1327279 /Source="Nicolas_upshifts" /id="U1092" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.898101898101898" /psig=1 /xcortree=1759 /SigmaFactorBS="cagcaaattacattaacatcatacgtcgaattCCTTGCATtt tcaaatggatgTTTTATAATTTAAATATACGggttcttttgaacttaaaataacggag g" /listShort="htpX" /GFF_Attribute="listLong" /label="upshifts" CDS 1327325..1328221 /gene="htpX" /locus_tag="BSU_13490" /old_locus_tag="BSU13490" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11860552, 12081643, 16076848, 16573693, 22447908, 22720735; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="membrane protease" /protein_id="NP_389232.1" /db_xref="EnsemblGenomes-Gn:BSU13490" /db_xref="EnsemblGenomes-Tr:CAB13222" /db_xref="GOA:O31657" /db_xref="InterPro:IPR001915" /db_xref="InterPro:IPR022919" /db_xref="SubtiList:BG13274" /db_xref="UniProtKB/Swiss-Prot:O31657" /translation="MAKRIFLFILTNILVLTTIGIVLSVLSSVTGVGTYFTADGGIDP MALLVFSLVVGFVGSFTSLAISRWMAKTMMGVRVLNPKKHSLSYEEQQLVDRVHRLSR SAGLTKMPEVGIYRSPEVNAFATGPSKRRSLVAVSSGLLEQMDDAAVEGVLAHEVAHI TNGDMVTMTLLQGIVNTFVVFLSRIAAWIASRFVKEDLAPIVHFIAMIIFQIVFSILG SLVVFAYSRHREFHADRGGADLAGKDKMIHALRTLKSYSSRILEDDQTAVQTLKINGK KRSSLFSTHPDLDERIRRLEAK*" /label="htpX CDS" gene 1327325..1328221 /gene="htpX" /locus_tag="BSU_13490" /old_locus_tag="BSU13490" /label="htpX gene" downshifts 1328215 /Source="Nicolas_upshifts" /id="D740" /incds=0 /nref=203 /ntot=268 /MaxReadThrough="3.02778" /MaxDrop="6.27746" /score="38.5173589" /energy="-13.4" /TU="NA" /idTUdmin="U1092" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1328326..1328330 /Source="Nicolas_upshift_promotors" /id="U1093" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.617382617382617" /psig="0.994005994005994" /xcortree=2515 /SigmaFactorBS="aaaaaataagcaagttaagaaaatgtttcgtaaaagCCTTTa aaaatggacctaatATCTTTAGAATAATTACCGTacttaaaaagagaggcagaaggat t" /listShort="ktrD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1328346..1328365 /Source="Nicolas_upshift_promotors" /id="U1093" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.617382617382617" /psig="0.994005994005994" /xcortree=2515 /SigmaFactorBS="aaaaaataagcaagttaagaaaatgtttcgtaaaagCCTTTa aaaatggacctaatATCTTTAGAATAATTACCGTacttaaaaagagaggcagaaggat t" /listShort="ktrD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1328350 /Source="Nicolas_upshifts" /id="U1093" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.617382617382617" /psig="0.994005994005994" /xcortree=2515 /SigmaFactorBS="aaaaaataagcaagttaagaaaatgtttcgtaaaagCCTTTa aaaatggacctaatATCTTTAGAATAATTACCGTacttaaaaagagaggcagaaggat t" /listShort="ktrD" /GFF_Attribute="listLong" /label="upshifts" CDS 1328395..1329744 /gene="ktrD" /locus_tag="BSU_13500" /old_locus_tag="BSU13500" /EC_number="3.6.3.12" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12562800, 15096624, 15849754, 16850406, 23963175" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562800, 15096624, 15849754, 16850406, 23963175; Product type t : transporter" /codon_start=1 /transl_table=11 /product="K+-transporting ATPase" /protein_id="NP_389233.1" /db_xref="EnsemblGenomes-Gn:BSU13500" /db_xref="EnsemblGenomes-Tr:CAB13223" /db_xref="GOA:O31658" /db_xref="InterPro:IPR003445" /db_xref="SubtiList:BG13275" /db_xref="UniProtKB/Swiss-Prot:O31658" /translation="MRLKFGKLIQALSPAQLIALYYFLAVTVAVILLSLPAAHKPGAD WTFIDALFTAVSSVSVTGLTVVDTADTFSTIGIFILAFVLQFGGIGIMTLGTFIWLIM GKRIGLKERKLIMVDQNQSQFSGIVNLMKQVLFLILWIEFFGGLILGTYFLTYYDSYQ EAYLHGFFASISATTNGGFDITGNSMIPFRHDYFVQFITMLLIIFGAIGFPVLVEVKD FLFSKHRRYPFTLFTKITTITFGSLVLFGAIGIFALEANHAFAGKSWHDILFLSLFQS TATRSGGLATIDISQLSDSTLFFICALMFIGASPSSVGGGIRTTTFALNLLALFHFAR GNKAVKVFKRELHPADLMKSLVVTMMAILLVFGATLILTITEKHSLLELLFEVCSAFG TTGLSLGITADLSSVGKCVIMIVMFIGRIGILTFLYLIGRKEIEANYHYPKERVIIG* " /label="ktrD CDS" gene 1328395..1329744 /gene="ktrD" /locus_tag="BSU_13500" /old_locus_tag="BSU13500" /label="ktrD gene" downshifts 1329732 /Source="Nicolas_upshifts" /id="D741" /incds=0 /nref=30 /ntot=182 /MaxReadThrough="0.838800000000001" /MaxDrop="4.37717" /score="20.0478288" /energy="-10.7" /TU="NA" /idTUdmin="U1093" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 1329793..1329799 /Source="Nicolas_upshift_promotors" /id="U1094" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=834 /SigmaFactorBS="tttgcggtgttttttgattaccaaaaaaaagaTGTGTGCctc ctgttcagttGGAGAACCTAACtccgacaggtgcaatttacgctcctgcatcttaaaa t" /listShort="S483, ykzP, ykzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1329813..1329824 /Source="Nicolas_upshift_promotors" /id="U1094" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=834 /SigmaFactorBS="tttgcggtgttttttgattaccaaaaaaaagaTGTGTGCctc ctgttcagttGGAGAACCTAACtccgacaggtgcaatttacgctcctgcatcttaaaa t" /listShort="S483, ykzP, ykzE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1329821..1329888 /Source="Nicolas_S_feature" /locus_tag="new_1417493_1417560" /HighExp="S8, S6, S7, S5, ferm, nit, BT, B36, Pyr, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S483" upshifts 1329821 /Source="Nicolas_upshifts" /id="U1094" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=834 /SigmaFactorBS="tttgcggtgttttttgattaccaaaaaaaagaTGTGTGCctc ctgttcagttGGAGAACCTAACtccgacaggtgcaatttacgctcctgcatcttaaaa t" /listShort="S483, ykzP, ykzE" /GFF_Attribute="listLong" /label="upshifts" CDS 1329889..1330044 /gene="ykzP" /locus_tag="BSU_13509" /old_locus_tag="BSU13509" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097718.1" /db_xref="EnsemblGenomes-Gn:BSU13509" /db_xref="EnsemblGenomes-Tr:CAX52609" /db_xref="UniProtKB/Swiss-Prot:C0H402" /translation="MKRKAEVNEAIKNNNTPTESMDPNSYKTQYHDDPNFRGANRNSK QGQQGGM*" /label="ykzP CDS" gene 1329889..1330044 /gene="ykzP" /locus_tag="BSU_13509" /old_locus_tag="BSU13509" /label="ykzP gene" CDS 1330047..1330223 /gene="ykzE" /locus_tag="BSU_13510" /old_locus_tag="BSU13510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 17322312" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389234.1" /db_xref="EnsemblGenomes-Gn:BSU13510" /db_xref="EnsemblGenomes-Tr:CAB13224" /db_xref="SubtiList:BG13333" /db_xref="UniProtKB/Swiss-Prot:O31659" /translation="MKKNRHSRDMQNHKKPMNKKVLEEEFSSELGDYNAGKIIETLEV TKPEKKKEKNKKQQ*" /label="ykzE CDS" gene 1330047..1330223 /gene="ykzE" /locus_tag="BSU_13510" /old_locus_tag="BSU13510" /label="ykzE gene" promotor_no_box 1330113..1330213 /Source="Nicolas_upshift_promotors" /id="U1095" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.683316683316683" /psig="0.005994005994006" /xcortree=278 /SigmaFactorBS="gaggaagaattctcaagtgaactcggggattacaatgccgga aagatcatcgaaacgctggaagtcaccaagcctgaaaagaaaaaagaaaaaaacaaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 1330173 /Source="Nicolas_upshifts" /id="U1095" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.683316683316683" /psig="0.005994005994006" /xcortree=278 /SigmaFactorBS="gaggaagaattctcaagtgaactcggggattacaatgccgga aagatcatcgaaacgctggaagtcaccaagcctgaaaagaaaaaagaaaaaaacaaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1330219 /Source="Nicolas_upshifts" /id="D742" /incds=0 /nref=56 /ntot=112 /MaxReadThrough="2.40289" /MaxDrop="8.38761" /score="26.5107018" /energy="-19.7" /TU="NA" /idTUdmin="U1094" /TUdmin=2 /isTUend="TRUE" /label="downshifts" CDS complement(1330266..1331288) /gene="ykrP" /locus_tag="BSU_13520" /old_locus_tag="BSU13520" /EC_number="2.3.-.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative integral membrane protein; putative acyltransferase" /protein_id="NP_389235.1" /db_xref="EnsemblGenomes-Gn:BSU13520" /db_xref="EnsemblGenomes-Tr:CAB13225" /db_xref="GOA:O31660" /db_xref="InterPro:IPR002656" /db_xref="SubtiList:BG13276" /db_xref="UniProtKB/Swiss-Prot:O31660" /translation="MSKSRDSYFDNAKFLLIFLVVFGHILRSFINDNHFMLYLYKFIY TFHMPAFILVSGYFAKGFKRAGYVKKLAVKLIIPYLIFQIIYSVFYYIMQDESMANVN PIDPQWSLWFLVSLFFWNLLLYPFSKLSKQWALFVSCGIAVLIGYLDFVSSTLSLSRT FVFLPMFLVGFYLNKHHFDLLRSKRGKQIALGVLAAVFVICWGIDFDYSFLFGSKPYS SFGDVTLVSGLSRIGWYVLAFGATFSFLALVPQKRYFFTKWGTRTFYVYLLHGFIIKT LRQVGLEDWLTDYQSLVILLLLTAALTSVLSSNFVKTVAQPFIELRMTSLLQFVRGTG KNAYLK*" /label="ykrP CDS" gene complement(1330266..1331288) /gene="ykrP" /locus_tag="BSU_13520" /old_locus_tag="BSU13520" /label="ykrP gene" downshifts complement(1330289) /Source="Nicolas_upshifts" /id="D743" /incds=0 /nref=11 /ntot=58 /MaxReadThrough="2.29259" /MaxDrop="3.64731" /score="30.4184602" /energy="-16.9" /TU="NA" /idTUdmin="U1096" /TUdmin=92 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1331333..1331352) /Source="Nicolas_upshift_promotors" /id="U1096" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.816183816183816" /psig="0.987012987012987" /xcortree=580 /SigmaFactorBS="ccgtcactttacatcgacctaacaatcagcatttttttaGAT TCCTttttcatctttTATTTTAAAATATGTACCAGcagggaataatctcttagtgact g" /listShort="ykrP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1331349) /Source="Nicolas_upshifts" /id="U1096" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.816183816183816" /psig="0.987012987012987" /xcortree=580 /SigmaFactorBS="ccgtcactttacatcgacctaacaatcagcatttttttaGAT TCCTttttcatctttTATTTTAAAATATGTACCAGcagggaataatctcttagtgact g" /listShort="ykrP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1331364..1331370) /Source="Nicolas_upshift_promotors" /id="U1096" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.816183816183816" /psig="0.987012987012987" /xcortree=580 /SigmaFactorBS="ccgtcactttacatcgacctaacaatcagcatttttttaGAT TCCTttttcatctttTATTTTAAAATATGTACCAGcagggaataatctcttagtgact g" /listShort="ykrP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1331477..1331485 /Source="Nicolas_upshift_promotors" /id="U1097" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=548 /SigmaFactorBS="gtaatgtaatgacgctgaaattttctgaaatttatagggcaa atGAAGGAAGTtcccgcatttTGTAGAAATATTGAGGGATaggttttgaagaaggagt g" /listShort="kinE, ogt, S485" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1331493 /Source="Nicolas_upshifts" /id="U1097" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=548 /SigmaFactorBS="gtaatgtaatgacgctgaaattttctgaaatttatagggcaa atGAAGGAAGTtcccgcatttTGTAGAAATATTGAGGGATaggttttgaagaaggagt g" /listShort="kinE, ogt, S485" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1331496..1331514 /Source="Nicolas_upshift_promotors" /id="U1097" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=548 /SigmaFactorBS="gtaatgtaatgacgctgaaattttctgaaatttatagggcaa atGAAGGAAGTtcccgcatttTGTAGAAATATTGAGGGATaggttttgaagaaggagt g" /listShort="kinE, ogt, S485" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1331541..1333757 /gene="kinE" /locus_tag="BSU_13530" /old_locus_tag="BSU13530" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11069677, 12169614, 16166384, 25701730" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11069677, 12169614, 16166384, 25701730; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase" /protein_id="NP_389236.1" /db_xref="EnsemblGenomes-Gn:BSU13530" /db_xref="EnsemblGenomes-Tr:CAB13226" /db_xref="GOA:O31661" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR013767" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG13277" /db_xref="UniProtKB/Swiss-Prot:O31661" /translation="METLGVQTNSELREELNRLKEENARLKKELNQHQVIVNNTLDAI FICDNEMRIVQANEATERMLQVDSEDLKKRSVLDFLFSIPKDELNLSVKKFFKKGFLW KEVPIRLDCGATKYIEFLAKRGIGEDFFFVVMRDISSKKILEREFSMNEQLFKDLFDR AVDGIVLFDKDGGFIDANLSFCKSFEINHNELSHLSLYEFIDSGSRKDFDNIWKALNR KGKAKGELPVKLRSGVQKLFEFTITSNIISGFYMSIMRDITEKRSMELQLFKSEERFR EIFENAMDAIIIWSNDGRIVKANQSACKIFELPMNLLLKRKLCDFLVDSQQKYSITKR KYAKYGEIREELLFQMGNGQFKELEFTSKRTILENQHLTILRNVSDRKRMEKELRESE LKFRKVFNGSMDGNVLFDNQYRIIDANPLASHILGLSHEEIKQHSLLDIISAYEIENL ASPARQINFDEMDNEIPFLLSSGDNRKLEFSFKRNIIQNMNLAIFKDVTERKELEERL RKSDTLHVVGELAAGIAHEIRNPMTALKGFIQLLKGSVEGDYALYFNVITSELKRIES IITEFLILAKPQAIMYEEKHVTQIMRDTIDLLNAQANLSNVQMQLDLIDDIPPIYCEP NQLKQVFINILKNAIEVMPDGGNIFVTIKALDQDHVLISLKDEGIGMTEDKLKRLGEP FYTTKERGTGLGLMVSYKIIEEHQGEIMVESEEGKGTVFHITLPVRQNAEERRNDE*" /label="kinE CDS" gene 1331541..1333757 /gene="kinE" /locus_tag="BSU_13530" /old_locus_tag="BSU13530" /label="kinE gene" S_feature complement(1333532..1334472) /Source="Nicolas_S_feature" /locus_tag="new_1421204_1422144_c" /HighExp="Pyr, Glucon, C30, Glu, Mal, M/G, G/S, Heat, Fru, B36" /AntisenseName="ogt" /AntisenseCor="-0.33210294457391598" /AntisenseRegPval="-7.6" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S484" promotor_-35 1333610..1333617 /Source="Nicolas_upshift_promotors" /id="U1098" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.999000999001" /xcortree=2063 /SigmaFactorBS="acttggtgaaccgttttatacgacaaaggaacggggAACTGG ACttgggcttatggtaAGCTATAAAATTATTGAAGAacatcaaggcgagattatggta g" /listShort="ogt, S485" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1333632..1333651 /Source="Nicolas_upshift_promotors" /id="U1098" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.999000999001" /xcortree=2063 /SigmaFactorBS="acttggtgaaccgttttatacgacaaaggaacggggAACTGG ACttgggcttatggtaAGCTATAAAATTATTGAAGAacatcaaggcgagattatggta g" /listShort="ogt, S485" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1333634 /Source="Nicolas_upshifts" /id="U1098" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.999000999001" /xcortree=2063 /SigmaFactorBS="acttggtgaaccgttttatacgacaaaggaacggggAACTGG ACttgggcttatggtaAGCTATAAAATTATTGAAGAacatcaaggcgagattatggta g" /listShort="ogt, S485" /GFF_Attribute="listLong" /label="upshifts" CDS 1333754..1334251 /gene="ogt" /locus_tag="BSU_13540" /old_locus_tag="BSU13540" /EC_number="2.1.1.63" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:2105461, 2308822, 2359121, 2506524, 7565865" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2105461, 2308822, 2359121, 2506524, 7565865; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="O6-alkylguanine DNA alkyltransferase" /protein_id="NP_389237.1" /db_xref="EnsemblGenomes-Gn:BSU13540" /db_xref="EnsemblGenomes-Tr:CAB13227" /db_xref="GOA:P11742" /db_xref="InterPro:IPR001497" /db_xref="InterPro:IPR008332" /db_xref="InterPro:IPR014048" /db_xref="InterPro:IPR023546" /db_xref="InterPro:IPR036217" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036631" /db_xref="SubtiList:BG10848" /db_xref="UniProtKB/Swiss-Prot:P11742" /translation="MNYYTTAETPLGELIIAEEEDRITRLFLSQEDWVDWKETVQNTE HKETPNLAEAKQQLQEYFAGERKTFSLPLSQKGTPFQQKVWQALERIPYGESRSYADI AAAVGSPKAVRAVGQANKRNDLPIFVPCHRVIGKNSALTGYAGSKTEIKAFLLNIERI SYKEK*" /label="ogt CDS" gene 1333754..1334251 /gene="ogt" /locus_tag="BSU_13540" /old_locus_tag="BSU13540" /label="ogt gene" S_feature 1334252..1334491 /Source="Nicolas_S_feature" /locus_tag="new_1421924_1422163" /HighExp="Lbstat, S2, BT, BC, LPhT, dia15, LBGstat, M0t90, M9-stat, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.981549" /TUshortSig="SigA, SigH" /TUshortPSig="0.999, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S485" CDS 1334341..1334466 /locus_tag="BSU_13545" /old_locus_tag="BSU13545" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513954.1" /translation="MKPSRSEKLAVFAELFVKLHILSSAQKDEIINVNKKKQKNR*" /label="hypothetical protein CDS" gene 1334341..1334466 /locus_tag="BSU_13545" /old_locus_tag="BSU13545" /label="gene" downshifts 1334459 /Source="Nicolas_upshifts" /id="D744" /incds=0 /nref=80 /ntot=239 /MaxReadThrough="1.90528" /MaxDrop="5.2481" /score="4.84132266" /energy="-15.5" /TU="NA" /idTUdmin="U1097" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(1334500..1335561) /gene="mtnA" /locus_tag="BSU_13550" /old_locus_tag="BSU13550" /EC_number="5.3.1.23" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14551435, 15102328, 16511105, 17690466, 18156470" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14551435, 15102328, 16511105, 17690466, 18156470; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylthioribose-1-phosphate isomerase (methionine salvage pathway)" /protein_id="NP_389238.1" /db_xref="EnsemblGenomes-Gn:BSU13550" /db_xref="EnsemblGenomes-Tr:CAB13228" /db_xref="GOA:O31662" /db_xref="InterPro:IPR000649" /db_xref="InterPro:IPR005251" /db_xref="InterPro:IPR011559" /db_xref="InterPro:IPR027363" /db_xref="PDB:2YRF" /db_xref="PDB:2YVK" /db_xref="SubtiList:BG13278" /db_xref="UniProtKB/Swiss-Prot:O31662" /translation="MTHSFAVPRSVEWKETAITILNQQKLPDETEYLELTTKEDVFDA IVTLKVRGAPAIGITAAFGLALAAKDIETDNVTEFRRRLEDIKQYLNSSRPTAINLSW ALERLSHSVENAISVNEAKTNLVHEAIQIQVEDEETCRLIGQNALQLFKKGDRIMTIC NAGSIATSRYGTALAPFYLAKQKDLGLHIYACETRPVLQGSRLTAWELMQGGIDVTLI TDSMAAHTMKEKQISAVIVGADRIAKNGDTANKIGTYGLAILANAFDIPFFVAAPLST FDTKVKCGADIPIEERDPEEVRQISGVRTAPSNVPVFNPAFDITPHDLISGIITEKGI MTGNYEEEIEQLFKGEKVH*" /label="mtnA CDS" gene complement(1334500..1335561) /gene="mtnA" /locus_tag="BSU_13550" /old_locus_tag="BSU13550" /label="mtnA gene" downshifts complement(1334517) /Source="Nicolas_upshifts" /id="D745" /incds=0 /nref=261 /ntot=286 /MaxReadThrough="4.47312" /MaxDrop="7.97339" /score="34.04363" /energy="-17.1" /TU="U1099,U1102" /idTUdmin="U1102" /TUdmin="-418" /isTUend="FALSE" /label="downshifts" CDS complement(1335569..1336762) /gene="mtnK" /locus_tag="BSU_13560" /old_locus_tag="BSU13560" /EC_number="2.7.1.100" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:210167, 11545674, 15102328, 17522047, 23649237" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 210167, 11545674, 15102328, 17522047, 23649237; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylthioribose kinase (methionine salvage pathway, promiscuous)" /protein_id="NP_389239.2" /db_xref="EnsemblGenomes-Gn:BSU13560" /db_xref="EnsemblGenomes-Tr:CAB13229" /db_xref="GOA:O31663" /db_xref="InterPro:IPR002575" /db_xref="InterPro:IPR009212" /db_xref="InterPro:IPR011009" /db_xref="PDB:2OLC" /db_xref="PDB:2PU8" /db_xref="PDB:2PUI" /db_xref="PDB:2PUL" /db_xref="PDB:2PUN" /db_xref="PDB:2PUP" /db_xref="SubtiList:BG13279" /db_xref="UniProtKB/Swiss-Prot:O31663" /translation="MGVTKTPLYETLNESSAVALAVKLGLFPSKSTLTCQEIGDGNLN YVFHIYDQEHDRALIIKQAVPYAKVVGESWPLTIDRARIESSALIRQGEHVPHLVPRV FYSDTEMAVTVMEDLSHLKIARKGLIEGENYPHLSQHIGEFLGKTLFYSSDYALEPKV KKQLVKQFTNPELCDITERLVFTDPFFDHDTNDFEEELRPFVEKLWNNDSVKIEAAKL KKSFLTSAETLIHGDLHTGSIFASEHETKVIDPEFAFYGPIGFDVGQFIANLFLNALS RDGADREPLYEHVNQVWETFEETFSEAWQKDSLDVYANIDGYLTDTLSHIFEEAIGFA GCELIRRTIGLAHVADLDTIVPFDKRIGRKRLALETGTAFIEKRSEFKTITDVIELFK LLVKE*" /label="mtnK CDS" gene complement(1335569..1336762) /gene="mtnK" /locus_tag="BSU_13560" /old_locus_tag="BSU13560" /label="mtnK gene" downshifts 1335629 /Source="Nicolas_upshifts" /id="D746" /incds=1 /nref=1 /ntot=51 /MaxReadThrough="3.02938" /MaxDrop="3.49719" /score="4.84132266" /energy="-15.5" /TU="NA" /idTUdmin="U1097" /TUdmin=1166 /isTUend="FALSE" /label="downshifts" downshifts complement(1336849) /Source="Nicolas_upshifts" /id="D747" /incds=0 /nref=1 /ntot=1 /MaxReadThrough="8.61071" /MaxDrop="3.05641" /score="27.7981655" /energy="-17.6" /TU="U1099,U1102" /idTUdmin="U1102" /TUdmin="-2750" /isTUend="FALSE" /label="downshifts" misc_RNA complement(1336855..1337011) /gene="mswC" /locus_tag="BSU_misc_RNA_20" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 15102328, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 15102328, 17381305, 18039762; Product type n : RNA" /function="12: Regulatory functions" /label="mswC RNA" gene complement(1336855..1337011) /gene="mswC" /locus_tag="BSU_misc_RNA_20" /label="mswC gene" promotor_-10 complement(1337046..1337065) /Source="Nicolas_upshift_promotors" /id="U1099" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2894 /SigmaFactorBS="agatttatattaaaaaataTATTGACAactaactaaattacc TGTTACCATGTTCATCAACTgataaattagaattgtcaaacaagtgaatatattctct t" /listShort="NA, mtnK, mtnA, S484" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1337047) /Source="Nicolas_upshifts" /id="U1099" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2894 /SigmaFactorBS="agatttatattaaaaaataTATTGACAactaactaaattacc TGTTACCATGTTCATCAACTgataaattagaattgtcaaacaagtgaatatattctct t" /listShort="NA, mtnK, mtnA, S484" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1337081..1337088) /Source="Nicolas_upshift_promotors" /id="U1099" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2894 /SigmaFactorBS="agatttatattaaaaaataTATTGACAactaactaaattacc TGTTACCATGTTCATCAACTgataaattagaattgtcaaacaagtgaatatattctct t" /listShort="NA, mtnK, mtnA, S484" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1337091..1337094 /Source="Nicolas_upshift_promotors" /id="U1100" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.276723276723277" /psig="0.98001998001998" /xcortree=2865 /SigmaFactorBS="ggtaacaggtaatttagttagttgtcaatataTTTTttaata taaatctttTCTGATATCATCGAAAACAGgaatgctctcccgaacttctgcgctttct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1337095..1337874) /gene="mtnU" /locus_tag="BSU_13570" /old_locus_tag="BSU13570" /EC_number="3.5.1.3" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12022921, 19464248, 19596042, 21288482, 23944997, 24387040; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ketoglutaramate omega-amidase" /protein_id="NP_389240.1" /db_xref="EnsemblGenomes-Gn:BSU13570" /db_xref="EnsemblGenomes-Tr:CAB13230" /db_xref="GOA:O31664" /db_xref="InterPro:IPR003010" /db_xref="InterPro:IPR036526" /db_xref="SubtiList:BG13280" /db_xref="UniProtKB/Swiss-Prot:O31664" /translation="MKWTISCLQFDISYGKPSENIKKAEFFIEKESKHADVLVLPELW TTGYDLANLDELADEDGRSAQSWLKKTAKKHGVHIVAGSVAVRKNSDVYNTMYIADKE GQIIKEYRKAHLFQLMDEHLYLSAGSEDGYFELDGVKSSGLICYDIRFPEWIRKHTTK GANVLFISAEWPLPRLDHWKSLLIARAIENQCFVAACNCTGSNPDNEFAGHSLIIDPW GRVLAEGGREEGIVRAEIDLQESAEVRESIPVFDDIRKDLY*" /label="mtnU CDS" gene complement(1337095..1337874) /gene="mtnU" /locus_tag="BSU_13570" /old_locus_tag="BSU13570" /label="mtnU gene" promotor_-10 1337110..1337129 /Source="Nicolas_upshift_promotors" /id="U1100" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.276723276723277" /psig="0.98001998001998" /xcortree=2865 /SigmaFactorBS="ggtaacaggtaatttagttagttgtcaatataTTTTttaata taaatctttTCTGATATCATCGAAAACAGgaatgctctcccgaacttctgcgctttct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1337119 /Source="Nicolas_upshifts" /id="U1100" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.276723276723277" /psig="0.98001998001998" /xcortree=2865 /SigmaFactorBS="ggtaacaggtaatttagttagttgtcaatataTTTTttaata taaatctttTCTGATATCATCGAAAACAGgaatgctctcccgaacttctgcgctttct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1337567..1337574 /Source="Nicolas_upshift_promotors" /id="U1101" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.634365634365634" /psig="0.99100899100899" /xcortree=2893 /SigmaFactorBS="ttttctgtactctttaatgatttgcCCTTCCTTatccgcgat gtaCATTGTATTATAAACATCAGaattcttcctgacagcgaccgatccggcgacaata t" /listShort="S486, mtnE" /listLong="NA, mtnW, mtnX, mtnB, mtnD" /label="promotor_-35" promotor_-10 1337587..1337606 /Source="Nicolas_upshift_promotors" /id="U1101" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.634365634365634" /psig="0.99100899100899" /xcortree=2893 /SigmaFactorBS="ttttctgtactctttaatgatttgcCCTTCCTTatccgcgat gtaCATTGTATTATAAACATCAGaattcttcctgacagcgaccgatccggcgacaata t" /listShort="S486, mtnE" /listLong="NA, mtnW, mtnX, mtnB, mtnD" /label="promotor_-10" upshifts 1337602 /Source="Nicolas_upshifts" /id="U1101" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.634365634365634" /psig="0.99100899100899" /xcortree=2893 /SigmaFactorBS="ttttctgtactctttaatgatttgcCCTTCCTTatccgcgat gtaCATTGTATTATAAACATCAGaattcttcctgacagcgaccgatccggcgacaata t" /listShort="S486, mtnE" /listLong="NA, mtnW, mtnX, mtnB, mtnD" /label="upshifts" S_feature 1337609..1337926 /Source="Nicolas_S_feature" /locus_tag="new_1425281_1425598" /HighExp="LoTm, S8, C30, BC, S7, B36, B60, T2.0H, Sw, UNK1" /AntisenseName="mtnU" /AntisenseCor="0.77659263363209297" /AntisenseRegPval="-54.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S486" promotor_-35 1337896..1337903 /Source="Nicolas_upshift_promotors" /id="U1103" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.929070929070929" /psig=1 /xcortree=3072 /SigmaFactorBS="atttcatctttttaacaccccaaattttTCTTTACTtttttc atttaaccATATATGATGATGGACTATCatttcaagatttttttagaaggtgagaata g" /listShort="mtnE, NA, mtnW, mtnX, mtnB, mtnD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1337904..1337923) /Source="Nicolas_upshift_promotors" /id="U1102" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.827172827172827" /psig=1 /xcortree=2895 /SigmaFactorBS="caaatttcatctattctcaccttctaaaaaaaTCTTGAAAtg atagtccatcatcATATATGGTTAAATGAAAAAagtaaagaaaaatttggggtgttaa a" /listShort="mtnU, NA, mtnK, mtnA, S484" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 1337918..1337937 /Source="Nicolas_upshift_promotors" /id="U1103" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.929070929070929" /psig=1 /xcortree=3072 /SigmaFactorBS="atttcatctttttaacaccccaaattttTCTTTACTtttttc atttaaccATATATGATGATGGACTATCatttcaagatttttttagaaggtgagaata g" /listShort="mtnE, NA, mtnW, mtnX, mtnB, mtnD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1337918) /Source="Nicolas_upshifts" /id="U1102" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.827172827172827" /psig=1 /xcortree=2895 /SigmaFactorBS="caaatttcatctattctcaccttctaaaaaaaTCTTGAAAtg atagtccatcatcATATATGGTTAAATGAAAAAagtaaagaaaaatttggggtgttaa a" /listShort="mtnU, NA, mtnK, mtnA, S484" /GFF_Attribute="listLong" /label="upshifts" upshifts 1337928 /Source="Nicolas_upshifts" /id="U1103" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.929070929070929" /psig=1 /xcortree=3072 /SigmaFactorBS="atttcatctttttaacaccccaaattttTCTTTACTtttttc atttaaccATATATGATGATGGACTATCatttcaagatttttttagaaggtgagaata g" /listShort="mtnE, NA, mtnW, mtnX, mtnB, mtnD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1337939..1337946) /Source="Nicolas_upshift_promotors" /id="U1102" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.827172827172827" /psig=1 /xcortree=2895 /SigmaFactorBS="caaatttcatctattctcaccttctaaaaaaaTCTTGAAAtg atagtccatcatcATATATGGTTAAATGAAAAAagtaaagaaaaatttggggtgttaa a" /listShort="mtnU, NA, mtnK, mtnA, S484" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1337969..1339165 /gene="mtnE" /locus_tag="BSU_13580" /old_locus_tag="BSU13580" /EC_number="2.6.1.1" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12670965, 15102328, 23429746, 24387040" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12670965, 15102328, 23429746, 24387040; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methionine-glutamine aminotransferase" /protein_id="NP_389241.1" /db_xref="EnsemblGenomes-Gn:BSU13580" /db_xref="EnsemblGenomes-Tr:CAB13231" /db_xref="GOA:O31665" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG13281" /db_xref="UniProtKB/Swiss-Prot:O31665" /translation="MKFEQSHVLKELPKQFFASLVQKVNRKLAEGHDVINLGQGNPDQ PTPEHIVEEMKRAVADPENHKYSSFRGSYRLKSAAAAFYKREYGIDLDPETEVAVLFG GKAGLVELPQCLLNPGDTILVPDPGYPDYWSGVTLAKAKMEMMPLVKDRAFLPDYSSI TAEIREQAKLMYLNYPNNPTGAVATSEFFEDTVRFAAENGICVVHDFAYGAVGFDGCK PLSFLQTEGAKDIGIEIYTLSKTYNMAGWRVGFAVGNASVIEAINLYQDHMFVSLFRA TQEAAAEALLADQTCVAEQNARYESRRNAWITACREIGWDVTAPAGSFFAWLPVPEGY TSEQFSDLLLEKANVAVAAGNGFGEYGEGYVRVGLLTSEERLKEAAYRIGKLNLFTQK SIDKTL*" /label="mtnE CDS" gene 1337969..1339165 /gene="mtnE" /locus_tag="BSU_13580" /old_locus_tag="BSU13580" /label="mtnE gene" promotor_-35 1339147..1339154 /Source="Nicolas_upshift_promotors" /id="U1104" /multdbtbs="SigA,SigA" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.998001998001998" /xcortree=2896 /SigmaFactorBS="acctgtttacccaaaaaagCATTGACAagaccttataacgaT GGGATAATTCAAAATAATTtataaaatctatattttcttatcaagagcaggcagaggg a" /listShort="NA, mtnW, mtnX, mtnB, mtnD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1339169..1339188 /Source="Nicolas_upshift_promotors" /id="U1104" /multdbtbs="SigA,SigA" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.998001998001998" /xcortree=2896 /SigmaFactorBS="acctgtttacccaaaaaagCATTGACAagaccttataacgaT GGGATAATTCAAAATAATTtataaaatctatattttcttatcaagagcaggcagaggg a" /listShort="NA, mtnW, mtnX, mtnB, mtnD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1339188 /Source="Nicolas_upshifts" /id="U1104" /multdbtbs="SigA,SigA" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.998001998001998" /xcortree=2896 /SigmaFactorBS="acctgtttacccaaaaaagCATTGACAagaccttataacgaT GGGATAATTCAAAATAATTtataaaatctatattttcttatcaagagcaggcagaggg a" /listShort="NA, mtnW, mtnX, mtnB, mtnD" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 1339204..1339304 /gene="mswD" /locus_tag="BSU_misc_RNA_21" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 15102328, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 15102328, 17381305, 18039762; Product type n : RNA" /function="16.3: Control" /label="mswD RNA" gene 1339204..1339304 /gene="mswD" /locus_tag="BSU_misc_RNA_21" /label="mswD gene" downshifts 1339303 /Source="Nicolas_upshifts" /id="D748" /incds=0 /nref=49 /ntot=190 /MaxReadThrough="7.27369" /MaxDrop="4.19981" /score="-1.80590532" /energy="-10.7" /TU="U1103,U1104" /idTUdmin="U1101" /TUdmin=110 /isTUend="FALSE" /label="downshifts" CDS 1339389..1340606 /gene="mtnW" /locus_tag="BSU_13590" /old_locus_tag="BSU13590" /EC_number="5.3.2.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12022921, 14551435, 15102328, 15950120, 16737967, 18403380" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12022921, 14551435, 15102328, 15950120, 16737967, 18403380; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="2,3-diketo-5-methylthiopentyl-1-phosphate enolase (DK-MTP-1-P enolase)" /protein_id="NP_389242.2" /db_xref="EnsemblGenomes-Gn:BSU13590" /db_xref="EnsemblGenomes-Tr:CAB13232" /db_xref="GOA:O31666" /db_xref="InterPro:IPR000685" /db_xref="InterPro:IPR017443" /db_xref="InterPro:IPR017717" /db_xref="InterPro:IPR033966" /db_xref="InterPro:IPR036376" /db_xref="InterPro:IPR036422" /db_xref="PDB:2ZVI" /db_xref="SubtiList:BG13282" /db_xref="UniProtKB/Swiss-Prot:O31666" /translation="MSELLATYLLTEPGADTEKKAEQIATGLTVGSWTDLPLVKQEQM QKHKGRVIKVEEREGTAASEKQAVITIAYPEINFSQDIPALLTTVFGKLSLDGKIKLI DLHFSEAFKRALPGPKFGVYGIRKLLGEFERPLLMSIFKGVIGRDLSDIKEQLRQQAL GGVDLIKDDEIFFETGLAPFETRIAEGKQILKETYEQTGHKTLYAVNLTGRTADLKDK ARRAAELGADALLFNVFAYGLDVMQGLAEDPEIPVPIMAHPAVSGAFTSSPFYGFSHA LLLGKLNRYCGADFSLFPSPYGSVALPRADALAIHEECVREDAFNQTFAVPSAGIHPG MVPLLMRDFGIDHIINAGGGVHGHPNGAQGGGRAFRAIIDAVLEAQPIDEKAEQCKDL KLALDKWGKAEAV*" /label="mtnW CDS" gene 1339389..1340606 /gene="mtnW" /locus_tag="BSU_13590" /old_locus_tag="BSU13590" /label="mtnW gene" CDS 1340603..1341310 /gene="mtnX" /locus_tag="BSU_13600" /old_locus_tag="BSU13600" /EC_number="3.1.3.87" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12022921, 14551435, 15102328, 15950120, 17654724" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12022921, 14551435, 15102328, 15950120, 17654724; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-hydroxy-3-keto-5-methylthiopentenyl-1- phosphatephosphatase (HK-MTPenyl-1-P phosphatase)" /protein_id="NP_389243.1" /db_xref="EnsemblGenomes-Gn:BSU13600" /db_xref="EnsemblGenomes-Tr:CAB13233" /db_xref="GOA:O31667" /db_xref="InterPro:IPR006384" /db_xref="InterPro:IPR017718" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="PDB:2FEA" /db_xref="SubtiList:BG13283" /db_xref="UniProtKB/Swiss-Prot:O31667" /translation="MTTRKPFIICDFDGTITMNDNIINIMKTFAPPEWMALKDGVLSK TLSIKEGVGRMFGLLPSSLKEEITSFVLEDAKIREGFREFVAFINEHEIPFYVISGGM DFFVYPLLEGIVEKDRIYCNHASFDNDYIHIDWPHSCKGTCSNQCGCCKPSVIHELSE PNQYIIMIGDSVTDVEAAKLSDLCFARDYLLNECREQNLNHLPYQDFYEIRKEIENVK EVQEWLQNKNAGESSLK*" /label="mtnX CDS" gene 1340603..1341310 /gene="mtnX" /locus_tag="BSU_13600" /old_locus_tag="BSU13600" /label="mtnX gene" CDS 1341268..1341897 /gene="mtnB" /locus_tag="BSU_13610" /old_locus_tag="BSU13610" /EC_number="4.2.1.109" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12022921, 14551435, 15102328, 18391471, 23285211" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12022921, 14551435, 15102328, 18391471, 23285211; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylthioribulose-1-phosphate dehydratase (MTRu-1-P dehydratase)" /protein_id="NP_389244.1" /db_xref="EnsemblGenomes-Gn:BSU13610" /db_xref="EnsemblGenomes-Tr:CAB13234" /db_xref="GOA:O31668" /db_xref="InterPro:IPR001303" /db_xref="InterPro:IPR017714" /db_xref="InterPro:IPR036409" /db_xref="SubtiList:BG13284" /db_xref="UniProtKB/Swiss-Prot:O31668" /translation="MAAKQERWRELAEVKRELAERDWFPATSGNLSIKVTDEPLTFLV TASGKDKRKETVEDFLLVDQNGEPAESGHSLKPSAETLLHTHLYNKTNAGCCLHVHTV NNNVISELYGDQKKITFKGQEIIKALGLWEENAEVTVPIIENPAHIPTLAALFAEEIS EDSGAVLIRNHGITAWGKTAFEAKRVLEAYEFLFSYHLKLKTLEHQLVK*" /label="mtnB CDS" gene 1341268..1341897 /gene="mtnB" /locus_tag="BSU_13610" /old_locus_tag="BSU13610" /label="mtnB gene" CDS 1341912..1342448 /gene="mtnD" /locus_tag="BSU_13620" /old_locus_tag="BSU13620" /EC_number="1.13.11.54" /EC_number="1.13.11.53" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10704478, 11371200, 12022880, 12022921, 12402029, 15102328, 16297065, 16783794, 24036122" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10704478, 11371200, 12022880, 12022921, 12402029, 15102328, 16297065, 16783794, 24036122; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acireductone dioxygenase (Ni2+ or Fe2+-requiring)" /protein_id="NP_389245.1" /db_xref="EnsemblGenomes-Gn:BSU13620" /db_xref="EnsemblGenomes-Tr:CAB13235" /db_xref="GOA:O31669" /db_xref="InterPro:IPR004313" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR023956" /db_xref="SubtiList:BG13285" /db_xref="UniProtKB/Swiss-Prot:O31669" /translation="MATIRIHDEANTTIENQEEVASFLDSQEVIYEQWDITRLPEHLS EKYDLTEEEKQQILDTFETEIKDISTRRGYKAQDVISLSDSNPKLDELLENFKREHHH TDDEVRFIVSGHGIFVIQGQDGTFFDVRLNPGDLISVPENIRHYFTLQEDRKVVAVRI FVTTEGWVPIYEKDSVNQ*" /label="mtnD CDS" gene 1341912..1342448 /gene="mtnD" /locus_tag="BSU_13620" /old_locus_tag="BSU13620" /label="mtnD gene" S_feature complement(1342295..1342488) /Source="Nicolas_S_feature" /locus_tag="new_1429967_1430160_c" /HighExp="Lbstat, Cold, LBGstat, T0.30H, M9-stat, B60, ferm, T1.30H, LPhT, M0t90" /AntisenseName="mtnD" /AntisenseCor="-0.31139057410816301" /AntisenseRegPval="-6.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S487" downshifts 1342448 /Source="Nicolas_upshifts" /id="D749" /incds=0 /nref=179 /ntot=227 /MaxReadThrough="1.58976" /MaxDrop="6.10661" /score="35.4563733" /energy="-14.9" /TU="NA" /idTUdmin="U1103" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1342489..1342809) /gene="ykvA" /locus_tag="BSU_13630" /old_locus_tag="BSU13630" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389246.1" /db_xref="EnsemblGenomes-Gn:BSU13630" /db_xref="EnsemblGenomes-Tr:CAB13236" /db_xref="GOA:O31670" /db_xref="InterPro:IPR010652" /db_xref="SubtiList:BG13308" /db_xref="UniProtKB/Swiss-Prot:O31670" /translation="MKKKKAIMLGAAGGKAILKRKNRKKCIQHITTFFQMLRDWRNGD YPRSQVKTLLLLTAAILYIVMPLDIIPDVILGLGFIDDAAVLGLIWTLIKKELSQYEK WRLQ*" /label="ykvA CDS" gene complement(1342489..1342809) /gene="ykvA" /locus_tag="BSU_13630" /old_locus_tag="BSU13630" /label="ykvA gene" downshifts complement(1342547) /Source="Nicolas_upshifts" /id="D750" /incds=0 /nref=5 /ntot=148 /MaxReadThrough="4.05831" /MaxDrop="2.74575" /score="18.5455371" /energy="-11.3" /TU="U1106" /idTUdmin="U1106" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" S_feature complement(1342810..1342899) /Source="Nicolas_S_feature" /locus_tag="new_1430482_1430571_c" /HighExp="Lbstat, M9-stat, B60, T0.30H, LBGstat, M0t90, T1.0H, S2, T3.0H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S488" promotor_-35 1342835..1342841 /Source="Nicolas_upshift_promotors" /id="U1105" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=237 /SigmaFactorBS="tcattgggcatacctcctgcctggcggcgTGTTTAAgatatt cttcacctGGGTATTGTTCTTCTAATCctatcaatatatctattatacctgaaaaatt a" /listShort="S489, S490, spo0E, eag" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1342856..1342874 /Source="Nicolas_upshift_promotors" /id="U1105" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=237 /SigmaFactorBS="tcattgggcatacctcctgcctggcggcgTGTTTAAgatatt cttcacctGGGTATTGTTCTTCTAATCctatcaatatatctattatacctgaaaaatt a" /listShort="S489, S490, spo0E, eag" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1342866 /Source="Nicolas_upshifts" /id="U1105" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=237 /SigmaFactorBS="tcattgggcatacctcctgcctggcggcgTGTTTAAgatatt cttcacctGGGTATTGTTCTTCTAATCctatcaatatatctattatacctgaaaaatt a" /listShort="S489, S490, spo0E, eag" /GFF_Attribute="listLong" /label="upshifts" S_feature 1342867..1342951 /Source="Nicolas_S_feature" /locus_tag="new_1430539_1430623" /HighExp="Etha, Gly, BC, Salt, Sw, B60, LoTm, M9-stat, LPhT, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S489" promotor_-10 complement(1342881..1342900) /Source="Nicolas_upshift_promotors" /id="U1106" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.682317682317682" /psig="0.999000999001" /xcortree=1602 /SigmaFactorBS="tgcattattacagattatactttatttgtaaacatattttCA TTaaataagttaatttTTCAGGTATAATAGATATATtgataggattagaagaacaata c" /listShort="S488, ykvA, S487" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1342898) /Source="Nicolas_upshifts" /id="U1106" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.682317682317682" /psig="0.999000999001" /xcortree=1602 /SigmaFactorBS="tgcattattacagattatactttatttgtaaacatattttCA TTaaataagttaatttTTCAGGTATAATAGATATATtgataggattagaagaacaata c" /listShort="S488, ykvA, S487" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1342915..1342918) /Source="Nicolas_upshift_promotors" /id="U1106" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.682317682317682" /psig="0.999000999001" /xcortree=1602 /SigmaFactorBS="tgcattattacagattatactttatttgtaaacatattttCA TTaaataagttaatttTTCAGGTATAATAGATATATtgataggattagaagaacaata c" /listShort="S488, ykvA, S487" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1342925..1342932 /Source="Nicolas_upshift_promotors" /id="U1107" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2934 /SigmaFactorBS="tacctgaaaaattaacttatttaatgaaaataTGTTTACAaa taaagtataatcTGTAATAATGCACAATAACCcaatcaaacttgtttcctatttctta g" /listShort="S490, spo0E, eag" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1342947..1342966 /Source="Nicolas_upshift_promotors" /id="U1107" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2934 /SigmaFactorBS="tacctgaaaaattaacttatttaatgaaaataTGTTTACAaa taaagtataatcTGTAATAATGCACAATAACCcaatcaaacttgtttcctatttctta g" /listShort="S490, spo0E, eag" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1342953..1343011 /Source="Nicolas_S_feature" /locus_tag="new_1430625_1430683" /HighExp="Etha, Gly, Sw, BC, LoTm, B36, T3.30H, Salt, T5.0H, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S490" upshifts 1342953 /Source="Nicolas_upshifts" /id="U1107" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2934 /SigmaFactorBS="tacctgaaaaattaacttatttaatgaaaataTGTTTACAaa taaagtataatcTGTAATAATGCACAATAACCcaatcaaacttgtttcctatttctta g" /listShort="S490, spo0E, eag" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(1343009) /Source="Nicolas_upshifts" /id="D751" /incds=0 /nref=3 /ntot=61 /MaxReadThrough="0.87927" /MaxDrop="3.53961" /score="18.5455371" /energy="-11.3" /TU="NA" /idTUdmin="U1106" /TUdmin="-682" /isTUend="FALSE" /label="downshifts" CDS 1343012..1343269 /gene="spo0E" /locus_tag="BSU_13640" /old_locus_tag="BSU13640" /function="16.13: Shape" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15057450, 15916600, 17001075, 19332814, 22524514" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15057450, 15916600, 17001075, 19332814, 22524514; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="negative regulatory phosphatase acting on Spo0A-P (sporulation)" /protein_id="NP_389247.1" /db_xref="EnsemblGenomes-Gn:BSU13640" /db_xref="EnsemblGenomes-Tr:CAB13237" /db_xref="GOA:P05043" /db_xref="InterPro:IPR018540" /db_xref="InterPro:IPR037208" /db_xref="SubtiList:BG10769" /db_xref="UniProtKB/Swiss-Prot:P05043" /translation="MGGSSEQERLLVSIDEKRKLMIDAARKQGFTGHDTIRHSQELDC LINEYHQLMQENEHSQGIQGLVKKLGLWPRRDVMPAYDANK*" /label="spo0E CDS" gene 1343012..1343269 /gene="spo0E" /locus_tag="BSU_13640" /old_locus_tag="BSU13640" /label="spo0E gene" downshifts 1343263 /Source="Nicolas_upshifts" /id="D752" /incds=0 /nref=7 /ntot=169 /MaxReadThrough="4.39402" /MaxDrop="3.59614" /score="0.224700481" /energy="-5.9" /TU="U1105,U1107" /idTUdmin="U1105" /TUdmin="-440" /isTUend="FALSE" /label="downshifts" CDS 1343355..1343786 /gene="eag" /locus_tag="BSU_13650" /old_locus_tag="BSU13650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative small membrane protein" /protein_id="NP_389248.1" /db_xref="EnsemblGenomes-Gn:BSU13650" /db_xref="EnsemblGenomes-Tr:CAB13238" /db_xref="GOA:P06630" /db_xref="SubtiList:BG10770" /db_xref="UniProtKB/Swiss-Prot:P06630" /translation="MKELAILITEMVNQFHDAFISLCGIFGIHLTDKEMHFWVIGIFG IFFFGVTHAVFTWLSKWSMTALSFIYTVTVIIVIVFAIEIQQKVTGRGNMEFLDATEG IKGFLVFFMFFLLLKMLLRFIKILFSGRPASKSNGNARSRR*" /label="eag CDS" gene 1343355..1343786 /gene="eag" /locus_tag="BSU_13650" /old_locus_tag="BSU13650" /label="eag gene" CDS complement(1343814..1345334) /gene="kinD" /locus_tag="BSU_13660" /old_locus_tag="BSU13660" /EC_number="2.7.13.3" /function="16.13: Shape" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11069677, 11673427, 16166384, 10411754, 21622736, 22074846, 22716461, 23569226" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11069677, 11673427, 16166384, 10411754, 21622736, 22074846, 22716461, 23569226; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="histidine kinase phosphorylating Spo0A" /protein_id="NP_389249.1" /db_xref="EnsemblGenomes-Gn:BSU13660" /db_xref="EnsemblGenomes-Tr:CAB13239" /db_xref="GOA:O31671" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033479" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="PDB:4JGO" /db_xref="PDB:4JGP" /db_xref="PDB:4JGQ" /db_xref="PDB:4JGR" /db_xref="SubtiList:BG13309" /db_xref="UniProtKB/Swiss-Prot:O31671" /translation="MLERCKLKILKGACGRVKLYIILVVIPAIVISFFVYEKEKDTIA AEHKQEASVLLNLHRNKINYLIGETMARMTSLSIAIDRPVDIKKMQSILEKTFDSEPR FSGLYFLNAKGDVTASTTELKTKVNLADRSFFIKAKETKKTVISDSYSSRITGQPIFT ICVPVLDSKRNVTDYLVAAIQIDYLKNLINLLSPDVYIEVVNQDGKMIFASGQASHAE DQKPVSGYLDDISWNMKVYPNPVTIEELSKSLVLPLSCIIVLLNILFILVLYYLLKRQ TQLERSENEAQKLELIGTLAASTAHEIRNPLTGISGFIQLLQKKYKGEEDQLYFSIIE QEIKRINQIVSEFLVLGKPTAEKWELNSLQDIIGEIMPIIYSEGNLYNVEVELQYLTE QPLLVKCTKDHIKQVILNVAKNGLESMPEGGKLTISLGALDKKAIIKVVDNGEGISQE MLDHIFLPFVTSKEKGTGLGLVVCKRIVLMYGGSIHIESEVRRGTEVTITLPVSAS*" /label="kinD CDS" gene complement(1343814..1345334) /gene="kinD" /locus_tag="BSU_13660" /old_locus_tag="BSU13660" /label="kinD gene" downshifts complement(1343826) /Source="Nicolas_upshifts" /id="D753" /incds=0 /nref=106 /ntot=227 /MaxReadThrough="0.62895" /MaxDrop="5.24795" /score="18.5455371" /energy="-11.3" /TU="NA" /idTUdmin="U1109" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" promotor_-35 1344535..1344541 /Source="Nicolas_upshift_promotors" /id="U1108" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=948 /SigmaFactorBS="ctgggtctgccgcttcagcaaataatacagcacgAGAATAAa aaggatattcagCAGAACAATAATacatgaaagcggaagcacaaggcttttcgacagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1344555..1344566 /Source="Nicolas_upshift_promotors" /id="U1108" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=948 /SigmaFactorBS="ctgggtctgccgcttcagcaaataatacagcacgAGAATAAa aaggatattcagCAGAACAATAATacatgaaagcggaagcacaaggcttttcgacagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1344561 /Source="Nicolas_upshifts" /id="U1108" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=948 /SigmaFactorBS="ctgggtctgccgcttcagcaaataatacagcacgAGAATAAa aaggatattcagCAGAACAATAATacatgaaagcggaagcacaaggcttttcgacagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(1345342..1345361) /Source="Nicolas_upshift_promotors" /id="U1109" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2145 /SigmaFactorBS="aagcttgccaacatctttttctaatttttttggttatttttt cttattaaagaagaagaaacAATGATATAATACCTCTAATcaggtgtatgttggagcg a" /listShort="kinD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1345363) /Source="Nicolas_upshifts" /id="U1109" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2145 /SigmaFactorBS="aagcttgccaacatctttttctaatttttttggttatttttt cttattaaagaagaagaaacAATGATATAATACCTCTAATcaggtgtatgttggagcg a" /listShort="kinD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1345461..1345468 /Source="Nicolas_upshift_promotors" /id="U1110" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2454 /SigmaFactorBS="cattttaaaaaagaagagaaatattggaaagattttTATTGA CAttttggtctttgttTATTAATGTTTCTCTGTAACggtttctaaaaggatgattgag a" /listShort="mhqR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1345483..1345502 /Source="Nicolas_upshift_promotors" /id="U1110" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2454 /SigmaFactorBS="cattttaaaaaagaagagaaatattggaaagattttTATTGA CAttttggtctttgttTATTAATGTTTCTCTGTAACggtttctaaaaggatgattgag a" /listShort="mhqR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1345485 /Source="Nicolas_upshifts" /id="U1110" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2454 /SigmaFactorBS="cattttaaaaaagaagagaaatattggaaagattttTATTGA CAttttggtctttgttTATTAATGTTTCTCTGTAACggtttctaaaaggatgattgag a" /listShort="mhqR" /GFF_Attribute="listLong" /label="upshifts" CDS 1345527..1345964 /gene="mhqR" /locus_tag="BSU_13670" /old_locus_tag="BSU13670" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17725564, 17962296, 18282125" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17725564, 17962296, 18282125; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (MarR family)" /protein_id="NP_389250.1" /db_xref="EnsemblGenomes-Gn:BSU13670" /db_xref="EnsemblGenomes-Tr:CAB13240" /db_xref="GOA:O31672" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13310" /db_xref="UniProtKB/Swiss-Prot:O31672" /translation="MTEKSLKLFIVLSRAYRSINDHMNKHIHKHGLNPTEFAVLELLY HKGDQPLQQIGDKILLASGSITYVVDKLEQKELLIRKASPTDRRVTFAQITEKGIGLL NDIFPDHAAEIDEMISVLSEEEVEMCTEMLKRVGLNAKQFHNK*" /label="mhqR CDS" gene 1345527..1345964 /gene="mhqR" /locus_tag="BSU_13670" /old_locus_tag="BSU13670" /label="mhqR gene" downshifts 1345947 /Source="Nicolas_upshifts" /id="D754" /incds=0 /nref=210 /ntot=257 /MaxReadThrough="1.20686" /MaxDrop="5.47215" /score="1.59181784" /energy="-8.9" /TU="U1110" /idTUdmin="U1110" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(1346004..1346789) /gene="motB" /locus_tag="BSU_13680" /old_locus_tag="BSU13680" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16095621, 18566286, 24296669, 24771657, 25273986" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16095621, 18566286, 24296669, 24771657, 25273986; Product type f: factor" /codon_start=1 /transl_table=11 /product="motility protein B; MotB component of the H+-coupled stator flagellum complex" /protein_id="NP_389251.1" /db_xref="EnsemblGenomes-Gn:BSU13680" /db_xref="EnsemblGenomes-Tr:CAB13241" /db_xref="GOA:P28612" /db_xref="InterPro:IPR006665" /db_xref="InterPro:IPR025713" /db_xref="InterPro:IPR036737" /db_xref="SubtiList:BG10689" /db_xref="UniProtKB/Swiss-Prot:P28612" /translation="MARKKKKKHEDEHVDESWLVPYADILTLLLALFIVLYASSSIDA AKFQMLSKSFNEVFTGGTGVLDYSSVTPPENESDGIDEVKKEKEEKEKNKKEKEKAAD QEELENVKSQVEKFIKDKKLEHQLETKMTSEGLLITIKDSIFFDSGKATIRKEDVPLA KEISNLLVINPPRNIIISGHTDNMPIKNSEFQSNWHLSVMRAVNFMGLLIENPKLDAK VFSAKGYGEYKPVASNKTAEGRSKNRRVEVLILPRGAAETNEK*" /label="motB CDS" gene complement(1346004..1346789) /gene="motB" /locus_tag="BSU_13680" /old_locus_tag="BSU13680" /label="motB gene" downshifts complement(1346023) /Source="Nicolas_upshifts" /id="D755" /incds=0 /nref=224 /ntot=246 /MaxReadThrough="3.05351" /MaxDrop="6.69306" /score="21.3673767" /energy="-12.4" /TU="U1111" /idTUdmin="U1111" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" downshifts complement(1346485) /Source="Nicolas_upshifts" /id="D756" /incds=1 /nref=1 /ntot=19 /MaxReadThrough="8.03566" /MaxDrop="4.69358" /score="21.3673767" /energy="-12.4" /TU="U1111" /idTUdmin="U1111" /TUdmin="-550" /isTUend="FALSE" /label="downshifts" CDS complement(1346761..1347573) /gene="motA" /locus_tag="BSU_13690" /old_locus_tag="BSU13690" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16095621, 18566286, 24296669, 24771657, 25273986" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16095621, 18566286, 24296669, 24771657, 25273986; Product type f: factor" /codon_start=1 /transl_table=11 /product="motility protein A; MotA component of the H+-coupled stator flagellum complex" /protein_id="NP_389252.1" /db_xref="EnsemblGenomes-Gn:BSU13690" /db_xref="EnsemblGenomes-Tr:CAB13242" /db_xref="GOA:P28611" /db_xref="InterPro:IPR000540" /db_xref="InterPro:IPR002898" /db_xref="SubtiList:BG10688" /db_xref="UniProtKB/Swiss-Prot:P28611" /translation="MDKTSLIGIILAFVALSVGMVLKGVSFSALANPAAILIIIAGTI SAVVIAFPTKEIKKVPTLFRVLFKENKQLTIEELIPMFSEWAQLARREGLLALEASIE DVDDAFLKNGLSMAVDGQSAEFIRDIMTEEVEAMEDRHQAGAAIFTQAGTYAPTLGVL GAVIGLIAALSHMDNTDELGHAISAAFVATLLGIFTGYVLWHPFANKLKRKSKQEVKL REVMIEGVLSVLEGQAPKVIEQKLLMYLPAKDRLKFAEQGEAQNGEKKEEEA*" /label="motA CDS" gene complement(1346761..1347573) /gene="motA" /locus_tag="BSU_13690" /old_locus_tag="BSU13690" /label="motA gene" promotor_-10 complement(1347604..1347622) /Source="Nicolas_upshift_promotors" /id="U1111" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2801 /SigmaFactorBS="tcttccttgaatatttcatgaacaaattcacaatgtcCCTAA AGTtccgggcaccaaaACCGATATTAACCATAGACaagctagtaaaaaaggatttggt g" /listShort="motA, motB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1347620) /Source="Nicolas_upshifts" /id="U1111" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2801 /SigmaFactorBS="tcttccttgaatatttcatgaacaaattcacaatgtcCCTAA AGTtccgggcaccaaaACCGATATTAACCATAGACaagctagtaaaaaaggatttggt g" /listShort="motA, motB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1347636..1347643) /Source="Nicolas_upshift_promotors" /id="U1111" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2801 /SigmaFactorBS="tcttccttgaatatttcatgaacaaattcacaatgtcCCTAA AGTtccgggcaccaaaACCGATATTAACCATAGACaagctagtaaaaaaggatttggt g" /listShort="motA, motB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1347711..1347933) /Source="Nicolas_S_feature" /locus_tag="new_1435383_1435605_c" /HighExp="Diami, dia15, dia5, Heat, Etha, LPhT, H2O2, C30, G135, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.93062599999999995" /TUshortSig="SigA" /TUshortPSig="0.671" /TUlongSig="NA" /TUlongPSig="NA" /label="S491" downshifts complement(1347743) /Source="Nicolas_upshifts" /id="D757" /incds=0 /nref=5 /ntot=12 /MaxReadThrough="0.48394" /MaxDrop="4.60081" /score="30.9355071" /energy="-15.4" /TU="NA" /idTUdmin="U1112" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(1347956..1350055) /gene="clpE" /locus_tag="BSU_13700" /old_locus_tag="BSU13700" /function="16.3: Control" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9987115, 10320580, 11069659, 14679237, 16788169, 16899079, 18689473, 19226326, 21208299, 28333276" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9987115, 10320580, 11069659, 14679237, 16788169, 16899079, 18689473, 19226326, 21208299, 28333276; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent Clp protease (class III stress gene)" /protein_id="NP_389253.1" /db_xref="EnsemblGenomes-Gn:BSU13700" /db_xref="EnsemblGenomes-Tr:CAB13243" /db_xref="GOA:O31673" /db_xref="InterPro:IPR001270" /db_xref="InterPro:IPR001943" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR018368" /db_xref="InterPro:IPR019489" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR028299" /db_xref="SubtiList:BG12578" /db_xref="UniProtKB/Swiss-Prot:O31673" /translation="MRCQHCHQNEATIRLNMQINSVHKQMVLCETCYNELTRKPSMSM GPQSFGFPFEQAFQPKEQSAAKQSEKKGLLDELAQNITNGAKAGLIDPVIGRDDEVAR VIEILNRRNKNNPVLIGEPGVGKTAIAEGLALKIAEGDVPNKLKNKELYLLDVASLVA NTGIRGQFEERMKQLITELKERKNVILFIDEIHLLVGAGSAEGSMDAGNILKPALARG ELQVIGATTLKEYRQIEKDAALERRFQPVMVQEPSIEQAILILQGIKDKYEAYHGVTF SDEAIKACVTLSSRYIQDRHLPDKAIDLLDEAGSKANLLIDELNDEDAAERLTAIEAE KTKALEEENYELAAKLRDEELALEKKLNSSSAHTAVTVEAEHIQEIVEQKTGIPVGKL QADEQTKMKELEAKLHERVIGQEAAVQKVAKAVRRSRAGLKSKNRPVGSFLFVGPTGV GKTELSKTLADELFGTKDAIIRLDMSEYMEKHAVSKIIGSPPGYVGHEEAGQLTEKVR RNPYSIVLLDEIEKAHPDVQHMFLQIMEDGRLTDSQGRTVSFKDTVIIMTSNAGAGEK QTKVGFQSDDSVIEEQTLIDSLSMFFKPEFLNRFDSIIEFRSLEKEHLVKIVSLLLGE LEETLAERGISLNVTDEAKEKIAELGYHPSFGARPLRRTIQEWVEDEMTDLLLDNGEI TSFHVILEDDKIKVRAK*" /label="clpE CDS" gene complement(1347956..1350055) /gene="clpE" /locus_tag="BSU_13700" /old_locus_tag="BSU13700" /label="clpE gene" downshifts complement(1347978) /Source="Nicolas_upshifts" /id="D758" /incds=0 /nref=27 /ntot=132 /MaxReadThrough="4.1802" /MaxDrop="6.07862" /score="41.2563375" /energy="-13.6" /TU="U1112" /idTUdmin="U1112" /TUdmin="-239" /isTUend="FALSE" /label="downshifts" S_feature complement(1350056..1350306) /Source="Nicolas_S_feature" /locus_tag="new_1437728_1437978_c" /HighExp="dia5, Heat, Diami, LPhT, dia15, H2O2, HiTm, S2, Cold, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.671" /TUlongSig="NA" /TUlongPSig="NA" /label="S492" promotor_no_box complement(1350266..1350366) /Source="Nicolas_upshift_promotors" /id="U1112" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.437562437562438" /psig="0.671328671328671" /xcortree=2025 /SigmaFactorBS="atgagacaagttccttgaaaagacgaagaaaacatgttttac tttgtaacaaatcaaaaatttttgtgcataagacttgaaagtcaaagatagtcagagt a" /listShort="S492, clpE, S491" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1350306) /Source="Nicolas_upshifts" /id="U1112" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.437562437562438" /psig="0.671328671328671" /xcortree=2025 /SigmaFactorBS="atgagacaagttccttgaaaagacgaagaaaacatgttttac tttgtaacaaatcaaaaatttttgtgcataagacttgaaagtcaaagatagtcagagt a" /listShort="S492, clpE, S491" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1350342..1350347 /Source="Nicolas_upshift_promotors" /id="U1113" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=984 /SigmaFactorBS="tgcacaaaaatttttgatttgttacaaagtaaaacatgtttt cttCGTCTTttcaaggaacttgtcTCATAGGTTATAAAAAGGCatatatggacaaaac t" /listShort="ykvI, S493" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1350357 /Source="Nicolas_upshifts" /id="U1113" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=984 /SigmaFactorBS="tgcacaaaaatttttgatttgttacaaagtaaaacatgtttt cttCGTCTTttcaaggaacttgtcTCATAGGTTATAAAAAGGCatatatggacaaaac t" /listShort="ykvI, S493" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1350363..1350381 /Source="Nicolas_upshift_promotors" /id="U1113" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=984 /SigmaFactorBS="tgcacaaaaatttttgatttgttacaaagtaaaacatgtttt cttCGTCTTttcaaggaacttgtcTCATAGGTTATAAAAAGGCatatatggacaaaac t" /listShort="ykvI, S493" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1350420..1351463 /gene="ykvI" /locus_tag="BSU_13710" /old_locus_tag="BSU13710" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15383836, 15849754, 16850406, 26735940; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_389254.1" /db_xref="EnsemblGenomes-Gn:BSU13710" /db_xref="EnsemblGenomes-Tr:CAB13244" /db_xref="GOA:O31674" /db_xref="SubtiList:BG13311" /db_xref="UniProtKB/Swiss-Prot:O31674" /translation="MEQSKGSASQLAFVYVGTVVGAGFATGREIVEFFLKFGWFGFFG ILVSGGMFTLLGAKLMIISKRINAKSYQEMNIFLFGATAGRIINVFMLFVLLGVTSVM LSGAGALFEEQLGMSAQIGMLITIGLSLIVMTRGVKGIFGVNVFVVPLLIIFSMIVVA DSFIFSESRNAAQWVWPHRWDWLLSAVSYGALNLSLAQAVLVPLANEMSSEKVIKKGA LIGGTMLTIVLSASFLSLSTLPDVFLYDIPMAQVVYLFARSVHLIYLLIIFGEVFTSV IGNLYGLEKQVQSFLPVKSKYIFAAIMITAYITSQIGYGRLISTIYPLFGYVSLAFIG ALLCKKAPRRRSL*" /label="ykvI CDS" gene 1350420..1351463 /gene="ykvI" /locus_tag="BSU_13710" /old_locus_tag="BSU13710" /label="ykvI gene" S_feature 1351464..1351555 /Source="Nicolas_S_feature" /locus_tag="new_1439136_1439227" /HighExp="S3, LoTm, S4, S5, BT, M9-stat, S6, T5.0H, T4.0H, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S493" promotor_-35 1351532..1351536 /Source="Nicolas_upshift_promotors" /id="U1114" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.906093906093906" /psig=1 /xcortree=2483 /SigmaFactorBS="cgataattgatctaggaaccggggactgactttttTATTGtc aagaaaaacatcatTATGGTAAGATAGCAGAAGTgaaaaaattgaagaaaatccgtgc g" /listShort="NA, S494, queC, queD, queE, queF, S495" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1351553..1351572 /Source="Nicolas_upshift_promotors" /id="U1114" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.906093906093906" /psig=1 /xcortree=2483 /SigmaFactorBS="cgataattgatctaggaaccggggactgactttttTATTGtc aagaaaaacatcatTATGGTAAGATAGCAGAAGTgaaaaaattgaagaaaatccgtgc g" /listShort="NA, S494, queC, queD, queE, queF, S495" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1351557 /Source="Nicolas_upshifts" /id="U1114" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.906093906093906" /psig=1 /xcortree=2483 /SigmaFactorBS="cgataattgatctaggaaccggggactgactttttTATTGtc aagaaaaacatcatTATGGTAAGATAGCAGAAGTgaaaaaattgaagaaaatccgtgc g" /listShort="NA, S494, queC, queD, queE, queF, S495" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 1351602..1351646 /gene="qswA" /locus_tag="BSU_misc_RNA_22" /product="preQ1 riboswitch" /experiment="publication(s) with functional evidences, PMID:17384645, 19234468, 19285444, 20534493, 21410253, 21592962, 24798077, 27484311" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17384645, 19234468, 19285444, 20534493, 21410253, 21592962, 24798077, 27484311; Product type n: RNA" /function="16.3: Control" /label="qswA RNA" gene 1351602..1351646 /gene="qswA" /locus_tag="BSU_misc_RNA_22" /label="qswA gene" downshifts 1351623 /Source="Nicolas_upshifts" /id="D759" /incds=0 /nref=11 /ntot=17 /MaxReadThrough="7.29177" /MaxDrop="4.09959" /score="21.1398563" /energy="-9.5" /TU="U1114" /idTUdmin="U1113" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1351668..1351775 /Source="Nicolas_S_feature" /locus_tag="new_1439340_1439447" /HighExp="Paraq, ferm, G180, LBGstat, Diami, H2O2, LPhT, Oxctl, G135, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S494" CDS 1351776..1352435 /gene="queC" /locus_tag="BSU_13720" /old_locus_tag="BSU13720" /EC_number="6.3.4.20" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:14660578, 16199558, 17384645, 18491386, 19354300" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14660578, 16199558, 17384645, 18491386, 19354300; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pre-queuosine 0 synthase" /protein_id="NP_389255.1" /db_xref="EnsemblGenomes-Gn:BSU13720" /db_xref="EnsemblGenomes-Tr:CAB13245" /db_xref="GOA:O31675" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR018317" /db_xref="PDB:3BL5" /db_xref="SubtiList:BG13312" /db_xref="UniProtKB/Swiss-Prot:O31675" /translation="MKKEKAIVVFSGGQDSTTCLLWALKEFEEVETVTFHYNQRHSQE VEVAKSIAEKLGVKNHLLDMSLLNQLAPNALTRNDIEIEVKDGELPSTFVPGRNLVFL SFASILAYQIGARHIITGVCETDFSGYPDCRDEFVKSCNVTVNLAMEKPFVIHTPLMW LNKAETWKLADELGALDFVKNNTLTCYNGIIADGCGECPACHLRSKGYEEYMVMKGER A*" /label="queC CDS" gene 1351776..1352435 /gene="queC" /locus_tag="BSU_13720" /old_locus_tag="BSU13720" /label="queC gene" CDS 1352428..1352877 /gene="queD" /locus_tag="BSU_13730" /old_locus_tag="BSU13730" /EC_number="4.1.2.50" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12123838, 14660578, 16199558, 18259064, 19231875" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12123838, 14660578, 16199558, 18259064, 19231875; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="6-carboxy-5,6,7,8-tetrahydropterin synthase; queuosine biosynthesis" /protein_id="NP_389256.1" /db_xref="EnsemblGenomes-Gn:BSU13730" /db_xref="EnsemblGenomes-Tr:CAB13246" /db_xref="GOA:O31676" /db_xref="InterPro:IPR007115" /db_xref="SubtiList:BG13313" /db_xref="UniProtKB/Swiss-Prot:O31676" /translation="MHKLLSQIYPQAQHPYSFELNKDMHISAAHFIPRESAGACSRVH GHTYTVNITVAGDELDDSGFLVNFSVLKKLVHGNYDHTLLNDHEDFSQDDRYSLPTTE VVAKTIYDNVQAYLDTLENKPTCVQVFVRETPTSYCVYRPKKGGLNG*" /label="queD CDS" gene 1352428..1352877 /gene="queD" /locus_tag="BSU_13730" /old_locus_tag="BSU13730" /label="queD gene" CDS 1352870..1353601 /gene="queE" /locus_tag="BSU_13740" /old_locus_tag="BSU13740" /EC_number="4.3.99.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12123838, 14660578, 16199558, 19354300, 23194065" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12123838, 14660578, 16199558, 19354300, 23194065; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="7-carboxy-7-deazaguanine synthase" /protein_id="NP_389257.1" /db_xref="EnsemblGenomes-Gn:BSU13740" /db_xref="EnsemblGenomes-Tr:CAB13247" /db_xref="GOA:O31677" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR017742" /db_xref="InterPro:IPR023404" /db_xref="InterPro:IPR024924" /db_xref="PDB:5TGS" /db_xref="PDB:5TH5" /db_xref="SubtiList:BG13314" /db_xref="UniProtKB/Swiss-Prot:O31677" /translation="MAKGIPVLEIFGPTIQGEGMVIGQKTMFVRTAGCDYSCSWCDSA FTWDGSAKKDIRWMTAEEIFAELKDIGGDAFSHVTISGGNPALLKQLDAFIELLKENN IRAALETQGTVYQDWFTLIDDLTISPKPPSSKMVTNFQKLDHILTSLQENDRQHAVSL KVVIFNDEDLEFAKTVHKRYPGIPFYLQVGNDDVHTTDDQSLIAHLLGKYEALVDKVA VDAELNLVRVLPQLHTLLWGNKRGV*" /label="queE CDS" gene 1352870..1353601 /gene="queE" /locus_tag="BSU_13740" /old_locus_tag="BSU13740" /label="queE gene" CDS 1353619..1354116 /gene="queF" /locus_tag="BSU_13750" /old_locus_tag="BSU13750" /EC_number="1.7.1.13" /function="10.3: tRNA and rRNA base modification" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12123838, 14660578, 16199558, 17929836, 22938038, 23410922, 28300774" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12123838, 14660578, 16199558, 17929836, 22938038, 23410922, 28300774; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADPH-dependent 7-cyano-7-deazaguanine reductase" /protein_id="NP_389258.1" /db_xref="EnsemblGenomes-Gn:BSU13750" /db_xref="EnsemblGenomes-Tr:CAB13248" /db_xref="GOA:O31678" /db_xref="InterPro:IPR016856" /db_xref="InterPro:IPR029500" /db_xref="PDB:4F8B" /db_xref="PDB:4FGC" /db_xref="PDB:5UDG" /db_xref="SubtiList:BG13315" /db_xref="UniProtKB/Swiss-Prot:O31678" /translation="MTTRKESELEGVTLLGNQGTNYLFEYAPDVLESFPNKHVNRDYF VKFNCPEFTSLCPKTGQPDFATIYISYIPDEKMVESKSLKLYLFSFRNHGDFHEDCMN IIMNDLIELMDPRYIEVWGKFTPRGGISIDPYTNYGKPGTKYEKMAEYRMMNHDLYPE TIDNR*" /label="queF CDS" gene 1353619..1354116 /gene="queF" /locus_tag="BSU_13750" /old_locus_tag="BSU13750" /label="queF gene" S_feature 1354117..1354393 /Source="Nicolas_S_feature" /locus_tag="new_1441789_1442065" /HighExp="Paraq, ferm, LPhT, C30, G135, G180, LBGstat, Oxctl, G150, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S495" downshifts 1354351 /Source="Nicolas_upshifts" /id="D760" /incds=0 /nref=200 /ntot=247 /MaxReadThrough="1.17154" /MaxDrop="6.60953" /score="11.1883045" /energy="-7.8" /TU="NA" /idTUdmin="U1114" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1354361) /Source="Nicolas_upshifts" /id="D761" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="1.54726" /MaxDrop="2.16508" /score="6.24357423" /energy="-7.6" /TU="NA" /idTUdmin="U1115" /TUdmin=110 /isTUend="FALSE" /label="downshifts" S_feature complement(1354430..1354674) /Source="Nicolas_S_feature" /locus_tag="new_1442102_1442346_c" /HighExp="Diami, dia5, LPhT, Etha, Salt, dia15, Heat, HiTm, C30, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.15795400000000001" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S496" downshifts complement(1354471) /Source="Nicolas_upshifts" /id="D762" /incds=0 /nref=47 /ntot=193 /MaxReadThrough="2.13712" /MaxDrop="5.08206" /score="6.24357423" /energy="-7.6" /TU="NA" /idTUdmin="U1115" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1354675..1355031) /gene="ykvN" /locus_tag="BSU_13760" /old_locus_tag="BSU13760" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16683018; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (HGT island)" /protein_id="NP_389259.1" /db_xref="EnsemblGenomes-Gn:BSU13760" /db_xref="EnsemblGenomes-Tr:CAB13249" /db_xref="GOA:O31679" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13316" /db_xref="UniProtKB/Swiss-Prot:O31679" /translation="MKKFSCGFEVTKEVIGGKWKGLVLYFLMNGPKRTSELKRIIPNI TQKMLIQTLRELEASGLVSRKMYNQVPPKVEYSSTELGESLKPILQELCQWGGYYAEQ EYAEGEYEIVQPEQLS*" /label="ykvN CDS" gene complement(1354675..1355031) /gene="ykvN" /locus_tag="BSU_13760" /old_locus_tag="BSU13760" /label="ykvN gene" misc_feature complement(1355062..1355081) /Source="Nicolas_upshift_promotors" /id="U1115" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.727272727272727" /psig="0.997002997002997" /xcortree=1897 /SigmaFactorBS="acaacttacaagatatagtatccttcagtaagcacattatcg gaagtacccactttttTGTGATATAGTAACTAAAAAgtaataaatgtggaatggagag c" /listShort="ykvN, S496" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1355079) /Source="Nicolas_upshifts" /id="U1115" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.727272727272727" /psig="0.997002997002997" /xcortree=1897 /SigmaFactorBS="acaacttacaagatatagtatccttcagtaagcacattatcg gaagtacccactttttTGTGATATAGTAACTAAAAAgtaataaatgtggaatggagag c" /listShort="ykvN, S496" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1355116..1355134 /Source="Nicolas_upshift_promotors" /id="U1116" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.313686313686314" /psig="0.954045954045954" /xcortree=1793 /SigmaFactorBS="ctttttagttactatatcacaaaaaagtgggtacttCcgata atgtgcttactgaAGGATACTATATCTTGTAAgttgttcttcaagtacttaaaggtac t" /listShort="ykvO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1355121 /Source="Nicolas_upshifts" /id="U1116" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.313686313686314" /psig="0.954045954045954" /xcortree=1793 /SigmaFactorBS="ctttttagttactatatcacaaaaaagtgggtacttCcgata atgtgcttactgaAGGATACTATATCTTGTAAgttgttcttcaagtacttaaaggtac t" /listShort="ykvO" /GFF_Attribute="listLong" /label="upshifts" CDS 1355200..1355946 /gene="ykvO" /locus_tag="BSU_13770" /old_locus_tag="BSU13770" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16683018, 26494135; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase (HGT island)" /protein_id="NP_389260.1" /db_xref="EnsemblGenomes-Gn:BSU13770" /db_xref="EnsemblGenomes-Tr:CAB13250" /db_xref="GOA:O31680" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13317" /db_xref="UniProtKB/Swiss-Prot:O31680" /translation="MGKFEGKIALVTGGTSGIGLATAQKFVNEGAYVYITGRRQNELD KAVNQIGKNVTGVQGDISKLEDLDKLYDIIKQEKGKLDILFANAGIGNFLPLGEITEE QVDRTFDINVKGTIFTVQKALSLFPDKVGSIIVTGSTAGSIGNPAFSVYGASKAALRA LVRNWILDLKGTEIRVNVVSPGGILTPAYDELFGDALEEVLENSRNTVPAGKVGTPEE VANAVSFLASDESSYLTGVELFVDGGLAQV*" /label="ykvO CDS" gene 1355200..1355946 /gene="ykvO" /locus_tag="BSU_13770" /old_locus_tag="BSU13770" /label="ykvO gene" downshifts 1356001 /Source="Nicolas_upshifts" /id="D763" /incds=0 /nref=19 /ntot=146 /MaxReadThrough="0.723690000000001" /MaxDrop="4.37163" /score="1.34631843" /energy="-9.1" /TU="NA" /idTUdmin="U1116" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1356349..1356357 /Source="Nicolas_upshift_promotors" /id="U1117" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1420 /SigmaFactorBS="tctcgtgatctcacacctgaacgttttttatagaCTAGTACC GcgacaagttatatTACATATACATACCAATAAAgtagacattaaaaagtgaaagaga g" /listShort="ykvP, ykzQ, S497, ykvQ, ykzR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1356371..1356390 /Source="Nicolas_upshift_promotors" /id="U1117" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1420 /SigmaFactorBS="tctcgtgatctcacacctgaacgttttttatagaCTAGTACC GcgacaagttatatTACATATACATACCAATAAAgtagacattaaaaagtgaaagaga g" /listShort="ykvP, ykzQ, S497, ykvQ, ykzR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1356375 /Source="Nicolas_upshifts" /id="U1117" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1420 /SigmaFactorBS="tctcgtgatctcacacctgaacgttttttatagaCTAGTACC GcgacaagttatatTACATATACATACCAATAAAgtagacattaaaaagtgaaagaga g" /listShort="ykvP, ykzQ, S497, ykvQ, ykzR" /GFF_Attribute="listLong" /label="upshifts" CDS 1356427..1357626 /gene="ykvP" /locus_tag="BSU_13780" /old_locus_tag="BSU13780" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11011148, 16683018" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11011148, 16683018; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore protein (HGT island)" /protein_id="NP_389261.1" /db_xref="EnsemblGenomes-Gn:BSU13780" /db_xref="EnsemblGenomes-Tr:CAB13251" /db_xref="GOA:O31681" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG13318" /db_xref="UniProtKB/Swiss-Prot:O31681" /translation="MKILFLESHPMWLYGLPNGFREAGHTVMISGPVSRENITEMIDE FKPDLIVSMGWTPEHSREKQAWIRNATKKVNIPLVYWATEDPLHTQNFTIPLIKKMKP DFVFTVTPSLCKTYESMGIKAAHLDFAFHESIHHQIKPLAKYSCDIAVVANAYPNFLE EHPEVFRSSSLKTLIRPLIRKGIRIDFWGRNWEKMSKYIGREIPRNWIHGYLDYTEAY KVYSSAKIIIGLQNCESQLTQRTYEILGSGGFLLTSDTPAVRGKFKPGRDLIVSSSPK ETLEKVKYYLNHDSERKKIQINGKKAVKNDSYRHRAERMLEVLKSRGIIRNLGETIHY VDVLKEKYVIHHVTPGETLSIIASKYNVSLQQLMELNHFKSDQIYAGQIIKIREKLFR NINNKLF*" /label="ykvP CDS" gene 1356427..1357626 /gene="ykvP" /locus_tag="BSU_13780" /old_locus_tag="BSU13780" /label="ykvP gene" promotor_-35 1356509..1356515 /Source="Nicolas_upshift_promotors" /id="U1118" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=152 /SigmaFactorBS="cgaatgggtttagggaagcaggacataccgtaaTGATTTCcg gtcctgtaagtcGGGAAAATATAACTGAAATgatagacgaatttaaaccagatttaat a" /listShort="ykzQ, S497, ykvQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1356530..1356548 /Source="Nicolas_upshift_promotors" /id="U1118" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=152 /SigmaFactorBS="cgaatgggtttagggaagcaggacataccgtaaTGATTTCcg gtcctgtaagtcGGGAAAATATAACTGAAATgatagacgaatttaaaccagatttaat a" /listShort="ykzQ, S497, ykvQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1356536 /Source="Nicolas_upshifts" /id="U1118" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=152 /SigmaFactorBS="cgaatgggtttagggaagcaggacataccgtaaTGATTTCcg gtcctgtaagtcGGGAAAATATAACTGAAATgatagacgaatttaaaccagatttaat a" /listShort="ykzQ, S497, ykvQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1357595..1357597 /Source="Nicolas_upshift_promotors" /id="U1119" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.346653346653347" /psig="0.602397602397602" /xcortree=2158 /SigmaFactorBS="acaaatcattaagattagagagaaacTGTttagaaatattaa taacaaATTATTCTAAAGGAGAGTAatatgaatgaaggggaaaatacctaaaataaga a" /listShort="ykzQ, S497, ykvQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1357617..1357635 /Source="Nicolas_upshift_promotors" /id="U1119" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.346653346653347" /psig="0.602397602397602" /xcortree=2158 /SigmaFactorBS="acaaatcattaagattagagagaaacTGTttagaaatattaa taacaaATTATTCTAAAGGAGAGTAatatgaatgaaggggaaaatacctaaaataaga a" /listShort="ykzQ, S497, ykvQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1357629 /Source="Nicolas_upshifts" /id="U1119" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.346653346653347" /psig="0.602397602397602" /xcortree=2158 /SigmaFactorBS="acaaatcattaagattagagagaaacTGTttagaaatattaa taacaaATTATTCTAAAGGAGAGTAatatgaatgaaggggaaaatacctaaaataaga a" /listShort="ykzQ, S497, ykvQ" /GFF_Attribute="listLong" /label="upshifts" CDS 1357642..1357869 /gene="ykzQ" /locus_tag="BSU_13789" /old_locus_tag="BSU13789" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative peptidoglycan binding protein" /protein_id="YP_003097719.1" /db_xref="EnsemblGenomes-Gn:BSU13789" /db_xref="EnsemblGenomes-Tr:CAX52610" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="UniProtKB/Swiss-Prot:C0H403" /translation="MKGKIPKIRNQANKVKRTPRYMEFPVTYEVYHVESGDTLWTIAK SFEIPVQQLMNLNKLSSDRIYPGQIIKIRER*" /label="ykzQ CDS" gene 1357642..1357869 /gene="ykzQ" /locus_tag="BSU_13789" /old_locus_tag="BSU13789" /label="ykzQ gene" misc_feature complement(1357719..1357738) /Source="Nicolas_upshift_promotors" /id="U1120" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.937062937062937" /psig="0.982017982017982" /xcortree=2163 /SigmaFactorBS="ggaatttcaaaggatttggcaatcgtccataatgtatcgccg gattccaCATGATATACTTCGTATGTCacgggaaattccatataacgaggcgttcttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1357727) /Source="Nicolas_upshifts" /id="U1120" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.937062937062937" /psig="0.982017982017982" /xcortree=2163 /SigmaFactorBS="ggaatttcaaaggatttggcaatcgtccataatgtatcgccg gattccaCATGATATACTTCGTATGTCacgggaaattccatataacgaggcgttcttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature 1357870..1357965 /Source="Nicolas_S_feature" /locus_tag="new_1445542_1445637" /HighExp="BT, S8, B36, S7, Etha, S6, G/S, LBGstat, Pyr, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB, SigK" /TUshortPSig="0.602, 0.999, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S497" CDS 1357966..1358664 /gene="ykvQ" /locus_tag="BSU_13790" /old_locus_tag="BSU13790" /EC_number="3.2.-.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16683018; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative sporulation-specific glycosylase (HGT island)" /db_xref="EnsemblGenomes-Gn:BSU13790" /db_xref="EnsemblGenomes-Tr:CAB13252" /db_xref="GOA:O31682" /db_xref="InterPro:IPR001223" /db_xref="InterPro:IPR011583" /db_xref="InterPro:IPR017853" /db_xref="PSEUDO:CAB13252.1" /db_xref="SubtiList:BG13319" /db_xref="UniProtKB/Swiss-Prot:O31682" /translation="MFQMSYYYSGLGWDFIQHVDQTNGVLNVVSPDFFYIRKDGSLLL RSANPDVIKALHRRKLKVVPFLSNHWDQDLGRFALMNRVLLAKQISHAIEELDLDGVN IDIENLTEKDRNLFTDFIRLVRKSIPRHKEVSVAVAANPFGWTKGWHGSYDYEYLAKY ADYLMVMAYDESRLAGPTASVGWVEKSIQYVLTQKISPQKLVLGLPFYGRCWMEGQSA SQAIPLYLVVSKKA*" /label="ykvQ CDS" gene 1357966..1358664 /gene="ykvQ" /locus_tag="BSU_13790" /old_locus_tag="BSU13790" /pseudo /label="ykvQ gene" S_feature complement(1358617..1359443) /Source="Nicolas_S_feature" /locus_tag="new_1446289_1447115_c" /HighExp="H2O2, M40t90, S8, M40t45, LPhT, Sw, Cold, LBGstat, C30, dia15" /AntisenseName="ykzR" /AntisenseCor="0.170402182980955" /AntisenseRegPval="-2.2999999999999998" /CDS_PredictionProba="0.38670900000000002" /TUshortSig="SigA" /TUshortPSig="0.986" /TUlongSig="NA" /TUlongPSig="NA" /label="S498" CDS 1358645..1358896 /gene="ykzR" /locus_tag="BSU_13799" /old_locus_tag="BSU13799" /function="16.8: Protect" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16683018; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative spore-specific glycosyl hydrolase" /db_xref="EnsemblGenomes-Gn:BSU13799" /db_xref="EnsemblGenomes-Tr:CAX52611" /db_xref="GOA:C0H404" /db_xref="InterPro:IPR017853" /db_xref="PSEUDO:CAX52611.1" /db_xref="UniProtKB/Swiss-Prot:C0H404" /translation="MLVKRHSGTIIFDTKSQSPKAIFTVNHDKKGPLPSGTYTLWFEN EQSLRAKIKLAQKYNLKGLGSWSLGQEDASVWNTVFKNI*" /label="ykzR CDS" gene 1358645..1358896 /gene="ykzR" /locus_tag="BSU_13799" /old_locus_tag="BSU13799" /pseudo /label="ykzR gene" misc_feature 1359146..1359161 /Source="Nicolas_upshift_promotors" /id="U1121" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.516483516483517" /psig="0.516483516483517" /xcortree=2456 /SigmaFactorBS="ctgcttccatgatttaatcatacacatgctacttgatAGCAG GGTTATCGCATttcattcagaattgttcaggatcgatatggaagcgcacgactaacta g" /listShort="S499" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1359169..1359380 /Source="Nicolas_S_feature" /locus_tag="new_1446841_1447052" /HighExp="Diami, S8, dia15, G180, HPh, C30, Paraq, H2O2, Salt, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigL" /TUshortPSig="0.516" /TUlongSig="NA" /TUlongPSig="NA" /label="S499" upshifts 1359169 /Source="Nicolas_upshifts" /id="U1121" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.516483516483517" /psig="0.516483516483517" /xcortree=2456 /SigmaFactorBS="ctgcttccatgatttaatcatacacatgctacttgatAGCAG GGTTATCGCATttcattcagaattgttcaggatcgatatggaagcgcacgactaacta g" /listShort="S499" /GFF_Attribute="listLong" /label="upshifts" downshifts 1359345 /Source="Nicolas_upshifts" /id="D764" /incds=0 /nref=2 /ntot=72 /MaxReadThrough="2.59168" /MaxDrop="2.74537" /score="-4.38958816" /energy="-9" /TU="NA" /idTUdmin="U1121" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1359432..1359451) /Source="Nicolas_upshift_promotors" /id="U1122" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.879120879120879" /psig="0.986013986013986" /xcortree=1501 /SigmaFactorBS="gttcttaacggttatatgaaccaattcattcgaaaagacaCC TTTACAaacatacgttcgttaAATTATAATAAAACAGACGAgctgccatccagcatcc c" /listShort="S498" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1359454) /Source="Nicolas_upshifts" /id="U1122" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.879120879120879" /psig="0.986013986013986" /xcortree=1501 /SigmaFactorBS="gttcttaacggttatatgaaccaattcattcgaaaagacaCC TTTACAaacatacgttcgttaAATTATAATAAAACAGACGAgctgccatccagcatcc c" /listShort="S498" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1359467..1359474) /Source="Nicolas_upshift_promotors" /id="U1122" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.879120879120879" /psig="0.986013986013986" /xcortree=1501 /SigmaFactorBS="gttcttaacggttatatgaaccaattcattcgaaaagacaCC TTTACAaacatacgttcgttaAATTATAATAAAACAGACGAgctgccatccagcatcc c" /listShort="S498" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1359519..1359526 /Source="Nicolas_upshift_promotors" /id="U1123" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.8001998001998" /psig=1 /xcortree=2042 /SigmaFactorBS="cgaatgaattggttcatataaccgttaagaacagatTCATTG TAaacattcgctaaggTATGCTAAGATGCATGGACTataaaggagtgatatgaagtga a" /listShort="ykvR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1359541..1359560 /Source="Nicolas_upshift_promotors" /id="U1123" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.8001998001998" /psig=1 /xcortree=2042 /SigmaFactorBS="cgaatgaattggttcatataaccgttaagaacagatTCATTG TAaacattcgctaaggTATGCTAAGATGCATGGACTataaaggagtgatatgaagtga a" /listShort="ykvR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1359543 /Source="Nicolas_upshifts" /id="U1123" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.8001998001998" /psig=1 /xcortree=2042 /SigmaFactorBS="cgaatgaattggttcatataaccgttaagaacagatTCATTG TAaacattcgctaaggTATGCTAAGATGCATGGACTataaaggagtgatatgaagtga a" /listShort="ykvR" /GFF_Attribute="listLong" /label="upshifts" CDS 1359579..1359869 /gene="ykvR" /locus_tag="BSU_13800" /old_locus_tag="BSU13800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein (HGT island)" /protein_id="NP_389263.1" /db_xref="EnsemblGenomes-Gn:BSU13800" /db_xref="EnsemblGenomes-Tr:CAB13253" /db_xref="InterPro:IPR021596" /db_xref="InterPro:IPR023105" /db_xref="PDB:2JN9" /db_xref="SubtiList:BG13320" /db_xref="UniProtKB/Swiss-Prot:O31683" /translation="MKTLRLNNVTLEMAAYQEESEPKRKIAFTLNVTSETYHDIAVLL YEKTFNVEVPERDLAFRGEMTNYSTSLTNLYEPGAVSEFYIEITEIDKNADS*" /label="ykvR CDS" gene 1359579..1359869 /gene="ykvR" /locus_tag="BSU_13800" /old_locus_tag="BSU13800" /label="ykvR gene" S_feature complement(1359906..1359989) /Source="Nicolas_S_feature" /locus_tag="new_1447578_1447661_c" /HighExp="Etha, dia5, Salt, SMMPr, Lbtran, dia15, Heat, S4, HiOs, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S500" downshifts complement(1359949) /Source="Nicolas_upshifts" /id="D765" /incds=0 /nref=216 /ntot=257 /MaxReadThrough="2.80569" /MaxDrop="6.83857" /score="21.3524751" /energy="-9.9" /TU="U1124" /idTUdmin="U1126" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1359990..1360175) /gene="ykvS" /locus_tag="BSU_13810" /old_locus_tag="BSU13810" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (HGT island)" /protein_id="NP_389264.2" /db_xref="EnsemblGenomes-Gn:BSU13810" /db_xref="EnsemblGenomes-Tr:CAB13254" /db_xref="InterPro:IPR018690" /db_xref="SubtiList:BG13321" /db_xref="UniProtKB/Swiss-Prot:O31684" /translation="MKIAKVGNVIEFKNGLTGVVEKVNENSVIVDVTIMDNYRDLELD SLTVVNHKNYKIIRDSY*" /label="ykvS CDS" gene complement(1359990..1360175) /gene="ykvS" /locus_tag="BSU_13810" /old_locus_tag="BSU13810" /label="ykvS gene" promotor_-10 complement(1360208..1360227) /Source="Nicolas_upshift_promotors" /id="U1124" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.665334665334665" /psig="0.995004995004995" /xcortree=2222 /SigmaFactorBS="aacaattcataagggagataaaactccttatCGCTTTACttc tcaatgaaaaTACTGCAAAATACTTTCAAAaggcattattatgtttaaaggagaggaa g" /listShort="ykvS, S500" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1360219) /Source="Nicolas_upshifts" /id="U1124" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.665334665334665" /psig="0.995004995004995" /xcortree=2222 /SigmaFactorBS="aacaattcataagggagataaaactccttatCGCTTTACttc tcaatgaaaaTACTGCAAAATACTTTCAAAaggcattattatgtttaaaggagaggaa g" /listShort="ykvS, S500" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1360221..1360565) /Source="Nicolas_S_feature" /locus_tag="new_1447893_1448237_c" /HighExp="S4, S8, S6, S5, S3, T5.0H, LoTm, S7, T4.0H, BT" /AntisenseName="ykzS" /AntisenseCor="-0.65556958045860303" /AntisenseRegPval="-33.700000000000003" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S501" promotor_-35 complement(1360241..1360248) /Source="Nicolas_upshift_promotors" /id="U1124" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.665334665334665" /psig="0.995004995004995" /xcortree=2222 /SigmaFactorBS="aacaattcataagggagataaaactccttatCGCTTTACttc tcaatgaaaaTACTGCAAAATACTTTCAAAaggcattattatgtttaaaggagaggaa g" /listShort="ykvS, S500" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1360274..1360279 /Source="Nicolas_upshift_promotors" /id="U1125" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.664335664335664" /psig="0.999000999001" /xcortree=1831 /SigmaFactorBS="taaagcgataaggagttttatctcccttatgaATTGTTctgt cgctataaagaTGATATATTGATTTTCGTCAatagaaagaaaaggggggaatttttgt t" /listShort="ykzS, ykvT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1360295..1360314 /Source="Nicolas_upshift_promotors" /id="U1125" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.664335664335664" /psig="0.999000999001" /xcortree=1831 /SigmaFactorBS="taaagcgataaggagttttatctcccttatgaATTGTTctgt cgctataaagaTGATATATTGATTTTCGTCAatagaaagaaaaggggggaatttttgt t" /listShort="ykzS, ykvT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1360302 /Source="Nicolas_upshifts" /id="U1125" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.664335664335664" /psig="0.999000999001" /xcortree=1831 /SigmaFactorBS="taaagcgataaggagttttatctcccttatgaATTGTTctgt cgctataaagaTGATATATTGATTTTCGTCAatagaaagaaaaggggggaatttttgt t" /listShort="ykzS, ykvT" /GFF_Attribute="listLong" /label="upshifts" CDS 1360341..1360535 /gene="ykzS" /locus_tag="BSU_13819" /old_locus_tag="BSU13819" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein (HGT island)" /protein_id="YP_003097721.1" /db_xref="EnsemblGenomes-Gn:BSU13819" /db_xref="EnsemblGenomes-Tr:CAX52612" /db_xref="UniProtKB/Swiss-Prot:C0H405" /translation="MRPEEITEMIEQLRTGAINELRVQKEHFLDFRAVLSKQDDFKHF RGIAQQGGDVIFQYLEQPRS*" /label="ykzS CDS" gene 1360341..1360535 /gene="ykzS" /locus_tag="BSU_13819" /old_locus_tag="BSU13819" /label="ykzS gene" downshifts 1360511 /Source="Nicolas_upshifts" /id="D766" /incds=0 /nref=6 /ntot=124 /MaxReadThrough="3.66738" /MaxDrop="3.03929" /score="5.82604583" /energy="-10.6" /TU="U1125" /idTUdmin="U1123" /TUdmin=682 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1360556..1360574) /Source="Nicolas_upshift_promotors" /id="U1126" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1145 /SigmaFactorBS="tactttacattttatttacacctgttacagacagctGTAATA aaaggcttgtgttctgTCATATATGATAAAAAGGCttctcacgtatgagaaaccttca g" /listShort="S501, ykvS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1360572) /Source="Nicolas_upshifts" /id="U1126" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1145 /SigmaFactorBS="tactttacattttatttacacctgttacagacagctGTAATA aaaggcttgtgttctgTCATATATGATAAAAAGGCttctcacgtatgagaaaccttca g" /listShort="S501, ykvS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1360591..1360596) /Source="Nicolas_upshift_promotors" /id="U1126" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1145 /SigmaFactorBS="tactttacattttatttacacctgttacagacagctGTAATA aaaggcttgtgttctgTCATATATGATAAAAAGGCttctcacgtatgagaaaccttca g" /listShort="S501, ykvS" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1360834..1361460 /gene="ykvT" /locus_tag="BSU_13820" /old_locus_tag="BSU13820" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12177332, 12950927, 23199363; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cell wall hydrolase related to spore cortex-lytic enzymes" /protein_id="NP_389265.1" /db_xref="EnsemblGenomes-Gn:BSU13820" /db_xref="EnsemblGenomes-Tr:CAB13255" /db_xref="GOA:O31685" /db_xref="InterPro:IPR011105" /db_xref="SubtiList:BG13322" /db_xref="UniProtKB/Swiss-Prot:O31685" /translation="MTTKFTALAVFLLCFMPAAKIEHTQASLLSAKKTKHEEAKWLTH IDRNTNESFPSLSADKDKKIKPIKLSAHTEKKEKDKPDKTNDEKETYTQSEKELLSRL VHAEAKGESYKGKVAVASVVLNRTEKKGFPDTIRGVIYQKNAFEPVANGSINQKPDKE SIEAAEEALSSKNRETDAIFFYNPKTASDNWIRSRKIVEKIGRHVFAV*" /label="ykvT CDS" gene 1360834..1361460 /gene="ykvT" /locus_tag="BSU_13820" /old_locus_tag="BSU13820" /label="ykvT gene" downshifts 1361391 /Source="Nicolas_upshifts" /id="D767" /incds=1 /nref=1 /ntot=17 /MaxReadThrough="0.932830000000001" /MaxDrop="1.92264" /score="9.80914166" /energy="-11.9" /TU="NA" /idTUdmin="U1125" /TUdmin=44 /isTUend="FALSE" /label="downshifts" promotor_-35 1361517..1361522 /Source="Nicolas_upshift_promotors" /id="U1127" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=991 /SigmaFactorBS="gagacaatttgtctcagctgtgctttttttcatataaagagt aaaaatAAAATAatttttgaacttgtcTCATATGATGTTGGTAGTAcaagagacaagg a" /listShort="ykvU, stoA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1361529 /Source="Nicolas_upshifts" /id="U1127" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=991 /SigmaFactorBS="gagacaatttgtctcagctgtgctttttttcatataaagagt aaaaatAAAATAatttttgaacttgtcTCATATGATGTTGGTAGTAcaagagacaagg a" /listShort="ykvU, stoA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1361538..1361556 /Source="Nicolas_upshift_promotors" /id="U1127" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=991 /SigmaFactorBS="gagacaatttgtctcagctgtgctttttttcatataaagagt aaaaatAAAATAatttttgaacttgtcTCATATGATGTTGGTAGTAcaagagacaagg a" /listShort="ykvU, stoA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1361578..1362915 /gene="ykvU" /locus_tag="BSU_13830" /old_locus_tag="BSU13830" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15686839, 15849754, 16850406, 19648239" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15686839, 15849754, 16850406, 19648239; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="spore membrane protein involved in germination" /protein_id="NP_389266.1" /db_xref="EnsemblGenomes-Gn:BSU13830" /db_xref="EnsemblGenomes-Tr:CAB13256" /db_xref="GOA:O31686" /db_xref="InterPro:IPR002797" /db_xref="InterPro:IPR024923" /db_xref="SubtiList:BG13323" /db_xref="UniProtKB/Swiss-Prot:O31686" /translation="MNRFVKGIILLSIAAFFAECLEFVVNMILARELGEHGMGLYMSI LPTIFLIIVIASLELPISISKFIAESNPKLHESMLRHAFRMTAIFTAFSTAAASIALP FIPVFDTYHPFIKGIVIGLIPVVAFTSIARGYFMGVQKMGKIAIANVLKKIIQLLCLF LFFQWYSFELDMAVLISLFVLVVSDVVVLVYLYSQFIMARRALSGQQHIHLRGKDVRK RLLAVSIPTTGLRIFHAVVNAIEPFLVKGALLAAGVAGTAAIDQYGMLAGVAVTIGSF PAFIAHSLMVVMIPSISEAYALSQYDIVLKRLKQSIFITLGYGIPAVWVMFQFAGPLT HLFFHSPEAQYYLQLLWPYFLFHLFVMPLQACLIGMGFVKEAFYHNVWSHIVALSMMY VLGSMENLQMLGIILGMNTGMILLTSLHYATICKALKVSVFLTGGTRTPRIEG*" /label="ykvU CDS" gene 1361578..1362915 /gene="ykvU" /locus_tag="BSU_13830" /old_locus_tag="BSU13830" /label="ykvU gene" CDS 1362966..1363463 /gene="stoA" /locus_tag="BSU_13840" /old_locus_tag="BSU13840" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15292147, 15322369, 15342593, 19144642, 28383125" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15292147, 15322369, 15342593, 19144642, 28383125; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore-specific thiol-disulfide oxidoreductase (SpoVD maturation)" /protein_id="NP_389267.1" /db_xref="EnsemblGenomes-Gn:BSU13840" /db_xref="EnsemblGenomes-Tr:CAB13257" /db_xref="GOA:O31687" /db_xref="InterPro:IPR000866" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR017937" /db_xref="InterPro:IPR036249" /db_xref="PDB:3ERW" /db_xref="SubtiList:BG13324" /db_xref="UniProtKB/Swiss-Prot:O31687" /translation="MLTKRLLTIYIMLLGLIAWFPGAAQAEEKQPAVPAVFLMKTIEG EDISIPNKGQKTILHFWTSWCPPCKKELPQFQSFYDAHPSDSVKLVTVNLVNSEQNQQ VVEDFIKANKLTFPIVLDSKGELMKEYHIITIPTSFLLNEKGEIEKTKIGPMTAEQLK EWTEE*" /label="stoA CDS" gene 1362966..1363463 /gene="stoA" /locus_tag="BSU_13840" /old_locus_tag="BSU13840" /label="stoA gene" promotor_-35 1363312..1363318 /Source="Nicolas_upshift_promotors" /id="U1128" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=267 /SigmaFactorBS="agcaagtcgttgaagactttattaaagcaaacaagctgacgt ttcCGATTGTccttgactcaaaagGGGAATTGATGAAGGAGTAtcatatcatcacgat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1363327 /Source="Nicolas_upshifts" /id="U1128" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=267 /SigmaFactorBS="agcaagtcgttgaagactttattaaagcaaacaagctgacgt ttcCGATTGTccttgactcaaaagGGGAATTGATGAAGGAGTAtcatatcatcacgat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1363333..1363351 /Source="Nicolas_upshift_promotors" /id="U1128" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=267 /SigmaFactorBS="agcaagtcgttgaagactttattaaagcaaacaagctgacgt ttcCGATTGTccttgactcaaaagGGGAATTGATGAAGGAGTAtcatatcatcacgat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 1363437 /Source="Nicolas_upshifts" /id="D768" /incds=0 /nref=36 /ntot=164 /MaxReadThrough="1.89069" /MaxDrop="4.34947" /score="14.1388498" /energy="-11.3" /TU="NA" /idTUdmin="U1127" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1363558..1363564 /Source="Nicolas_upshift_promotors" /id="U1129" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.832167832167832" /psig=1 /xcortree=1532 /SigmaFactorBS="tattatcaaaaagaaattaaaataattataaTTGAAATtctc ttcgtgCGTGCTATAATAAAGGAAGAcatcaagaaataactgacgataaagctgcctt t" /listShort="S502, zosA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1363575..1363594 /Source="Nicolas_upshift_promotors" /id="U1129" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.832167832167832" /psig=1 /xcortree=1532 /SigmaFactorBS="tattatcaaaaagaaattaaaataattataaTTGAAATtctc ttcgtgCGTGCTATAATAAAGGAAGAcatcaagaaataactgacgataaagctgcctt t" /listShort="S502, zosA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1363587 /Source="Nicolas_upshifts" /id="U1129" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.832167832167832" /psig=1 /xcortree=1532 /SigmaFactorBS="tattatcaaaaagaaattaaaataattataaTTGAAATtctc ttcgtgCGTGCTATAATAAAGGAAGAcatcaagaaataactgacgataaagctgcctt t" /listShort="S502, zosA" /GFF_Attribute="listLong" /label="upshifts" S_feature 1363591..1363698 /Source="Nicolas_S_feature" /locus_tag="new_1451263_1451370" /HighExp="LBGstat, C90, Lbstat, BC, Cold, T0.30H, Etha, Lbtran, LBGtran, BI" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S502" CDS 1363699..1365612 /gene="pfeT" /locus_tag="BSU_13850" /old_locus_tag="BSU13850" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12029044, 12180919, 15802251, 21813502, 26261021, 26566138" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12029044, 12180919, 15802251, 21813502, 26261021, 26566138; Product type t : transporter" /codon_start=1 /transl_table=11 /product="Fe(II) efflux transporter possibly involved in copper(II) uptake" /protein_id="NP_389268.1" /db_xref="EnsemblGenomes-Gn:BSU13850" /db_xref="EnsemblGenomes-Tr:CAB13258" /db_xref="GOA:O31688" /db_xref="InterPro:IPR001757" /db_xref="InterPro:IPR008250" /db_xref="InterPro:IPR018303" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR023298" /db_xref="InterPro:IPR023299" /db_xref="InterPro:IPR027256" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG13325" /db_xref="UniProtKB/Swiss-Prot:O31688" /translation="MNEQVIVQRDPHEPLKTDKREKNWAQHAELIAALVSGALILAGW LLSGYQVLSIILFLLAFVIGGFAKAKEGIEETLESKTLNVELLMIFAAIGSALIGYWA EGAILIFIFSLSGALETYTMNKSSRDLTSLMQLEPEEATLMVNGETKRVPVSDLQAGD MIVIKPGERVAADGIIESGSTSLDESALTGESMPVEKNTGDTVFTGTVNRNGSLTVRV TKANEDSLFRKIIKLVESAQNSVSPAQAFIERFENAYVKGVLIAVALLLFVPHFALGW SWSETFYRAMVFMVVASPCALVASIMPAALSLISNGARNGMLVKGSVFLEQLGSVQMI AFDKTGTVTKGQPAVETIRIAEGFSEAEVLEAVYAIETQSSHPLAQAITAYAESRGVN QSGYISIEETSGFGVMAEVSGAKWKVGKAGFIGEEMAAQFMKQTASDVIQSGHTIVFV KKDDQIAGCIALKDQIRPEAKEVMEELNRLGIKTAMLTGDHEDTAQAIAKEAGMTTVV AECLPDQKVNEIKRLKEEFGTIAMVGDGINDAPALKAADVGIAMGGGTDVALETADMV LMKNDLKKLVNMCRLSRKMNRIIKQNIVFSLAVICLLICANFLQAMELPFGVIGHEGS TILVILNGLRLLK*" /label="pfeT CDS" gene 1363699..1365612 /gene="pfeT" /locus_tag="BSU_13850" /old_locus_tag="BSU13850" /label="pfeT gene" promotor_-10 complement(1363848..1363867) /Source="Nicolas_upshift_promotors" /id="U1130" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1375 /SigmaFactorBS="gtttcttcgattccttccttcgctttagcaaatccgCCGATC ACAAaagccagcaagaAAAGTATTATGGATAATACCtgatatccggataagagccagc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1363865) /Source="Nicolas_upshifts" /id="U1130" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1375 /SigmaFactorBS="gtttcttcgattccttccttcgctttagcaaatccgCCGATC ACAAaagccagcaagaAAAGTATTATGGATAATACCtgatatccggataagagccagc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1363880..1363889) /Source="Nicolas_upshift_promotors" /id="U1130" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1375 /SigmaFactorBS="gtttcttcgattccttccttcgctttagcaaatccgCCGATC ACAAaagccagcaagaAAAGTATTATGGATAATACCtgatatccggataagagccagc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1364016..1364035) /Source="Nicolas_upshift_promotors" /id="U1131" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=748 /SigmaFactorBS="gctgcattaaagacgttaaatctctgctgcttttattcatcg tgtaTGTTTCTaaagctccgcttaAGGAAAAAATAAATATTAAAatagcaccctctgc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1364041) /Source="Nicolas_upshifts" /id="U1131" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=748 /SigmaFactorBS="gctgcattaaagacgttaaatctctgctgcttttattcatcg tgtaTGTTTCTaaagctccgcttaAGGAAAAAATAAATATTAAAatagcaccctctgc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1364049..1364055) /Source="Nicolas_upshift_promotors" /id="U1131" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=748 /SigmaFactorBS="gctgcattaaagacgttaaatctctgctgcttttattcatcg tgtaTGTTTCTaaagctccgcttaAGGAAAAAATAAATATTAAAatagcaccctctgc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1365593 /Source="Nicolas_upshifts" /id="D769" /incds=0 /nref=62 /ntot=148 /MaxReadThrough="2.05978" /MaxDrop="6.90668" /score="30.2111295" /energy="-18" /TU="NA" /idTUdmin="U1129" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1365669) /Source="Nicolas_upshifts" /id="D770" /incds=0 /nref=74 /ntot=208 /MaxReadThrough="0.83751" /MaxDrop="4.23141" /score="34.2342147" /energy="-18" /TU="NA" /idTUdmin="U1132" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1365880..1365899) /Source="Nicolas_upshift_promotors" /id="U1132" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.684315684315684" /psig="0.999000999001" /xcortree=3126 /SigmaFactorBS="gcctttcacgacgccttcattttctaatgCATTTTATttcct gctcctctTCCTGTATACTGACAGTAACgttcaatcgcaggggggttgttccgtttgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1365889) /Source="Nicolas_upshifts" /id="U1132" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.684315684315684" /psig="0.999000999001" /xcortree=3126 /SigmaFactorBS="gcctttcacgacgccttcattttctaatgCATTTTATttcct gctcctctTCCTGTATACTGACAGTAACgttcaatcgcaggggggttgttccgtttgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1365913..1365920) /Source="Nicolas_upshift_promotors" /id="U1132" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.684315684315684" /psig="0.999000999001" /xcortree=3126 /SigmaFactorBS="gcctttcacgacgccttcattttctaatgCATTTTATttcct gctcctctTCCTGTATACTGACAGTAACgttcaatcgcaggggggttgttccgtttgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 1365964..1365983 /Source="Nicolas_upshift_promotors" /id="U1133" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.434565434565435" /psig=1 /xcortree=1996 /SigmaFactorBS="taaaatgcattagaaaatgaaggcgtcgtgaaaggcaaacac cggtaaaaCCTGTTACAATGGAAGACAGaacaatgcattgcaaatggcagggaggaac a" /listShort="ykvY, S504, ykvZ, glcT, S505, ptsG, ptsH, ptsI" /listLong="splA, splB" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1365974 /Source="Nicolas_upshifts" /id="U1133" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.434565434565435" /psig=1 /xcortree=1996 /SigmaFactorBS="taaaatgcattagaaaatgaaggcgtcgtgaaaggcaaacac cggtaaaaCCTGTTACAATGGAAGACAGaacaatgcattgcaaatggcagggaggaac a" /listShort="ykvY, S504, ykvZ, glcT, S505, ptsG, ptsH, ptsI" /listLong="splA, splB" /label="upshifts" CDS 1366019..1367110 /gene="papB" /locus_tag="BSU_13860" /old_locus_tag="BSU13860" /EC_number="3.4.13.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7770058, 23144141" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7770058, 23144141; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Xaa-Pro Xaa-Pro-Xaa di-tri-peptidase used in osmoprotection" /protein_id="NP_389269.1" /db_xref="EnsemblGenomes-Gn:BSU13860" /db_xref="EnsemblGenomes-Tr:CAB13259" /db_xref="GOA:O31689" /db_xref="InterPro:IPR000587" /db_xref="InterPro:IPR000994" /db_xref="InterPro:IPR001131" /db_xref="InterPro:IPR001714" /db_xref="InterPro:IPR029149" /db_xref="InterPro:IPR036005" /db_xref="SubtiList:BG13326" /db_xref="UniProtKB/Swiss-Prot:O31689" /translation="MNRIQRVSSWLKEAGHTAAFIHTKENVFYLTGFYTEPHERLMGL FIFQEEEPFFVCPGMEAGQARNAGWNHEIIGYADHENPWELIEKALKKRNISIHMLAV EKDSISLSRAEQLKHATGGAQFVSAEETLNQFRLIKDDNEIRLLKEAAKLADYGVEVG TAALREGISEVEVLAQIEYELKKKGIQGMSFSTMVLFGEKSGQPHGNPGTATLKKGDF VLFDLGVILDGYCSDITRTFAYKTINPKQEAIYETVLQAEKAAIEASKPGVRIGDLDL TARGIIEKAGYGDYFPHRLGHGLGISVHEYPSMSQANDTLLQEGMVYTIEPGIYVPEI GGVRIEDDVHVTKDGAVALTQYPKDLIIL*" /label="papB CDS" gene 1366019..1367110 /gene="papB" /locus_tag="BSU_13860" /old_locus_tag="BSU13860" /label="papB gene" downshifts 1366759 /Source="Nicolas_upshifts" /id="D771" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="6.10599" /MaxDrop="5.06339" /score="-5.18621526" /energy="-6.2" /TU="U1133" /idTUdmin="U1129" /TUdmin=1166 /isTUend="FALSE" /label="downshifts" downshifts 1367089 /Source="Nicolas_upshifts" /id="D772" /incds=0 /nref=2 /ntot=52 /MaxReadThrough="5.66039" /MaxDrop="2.56719" /score="-5.18621526" /energy="-6.2" /TU="U1133" /idTUdmin="U1129" /TUdmin=1496 /isTUend="FALSE" /label="downshifts" S_feature complement(1367123..1367341) /Source="Nicolas_S_feature" /locus_tag="new_1454795_1455013_c" /HighExp="B60, B36, C30, G135, LBGstat, S8, Lbstat, C90, Etha, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.92748200000000003" /TUshortSig="SigA" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S503" S_feature 1367134..1367391 /Source="Nicolas_S_feature" /locus_tag="new_1454806_1455063" /HighExp="dia15, dia5, Etha, M0t90, M40t90, Lbstat, H2O2, G150, Mt0, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S504" promotor_-10 complement(1367328..1367347) /Source="Nicolas_upshift_promotors" /id="U1134" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.906093906093906" /psig="0.992007992007992" /xcortree=603 /SigmaFactorBS="tattagccatagattcccttctttctaaatcCCCTTGATctg gaatgcgtttcaTACAATATGATATGGACGTAccagatatctttttgtgtttttagct g" /listShort="S503" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1367341) /Source="Nicolas_upshifts" /id="U1134" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.906093906093906" /psig="0.992007992007992" /xcortree=603 /SigmaFactorBS="tattagccatagattcccttctttctaaatcCCCTTGATctg gaatgcgtttcaTACAATATGATATGGACGTAccagatatctttttgtgtttttagct g" /listShort="S503" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1367363..1367370) /Source="Nicolas_upshift_promotors" /id="U1134" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.906093906093906" /psig="0.992007992007992" /xcortree=603 /SigmaFactorBS="tattagccatagattcccttctttctaaatcCCCTTGATctg gaatgcgtttcaTACAATATGATATGGACGTAccagatatctttttgtgtttttagct g" /listShort="S503" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1367392..1368357 /gene="ykvZ" /locus_tag="BSU_13870" /old_locus_tag="BSU13870" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (LacI family)" /protein_id="NP_389270.1" /db_xref="EnsemblGenomes-Gn:BSU13870" /db_xref="EnsemblGenomes-Tr:CAB13260" /db_xref="GOA:O31690" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR001761" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG13327" /db_xref="UniProtKB/Swiss-Prot:O31690" /translation="MANIKDIAEKAGVSVTTVSRVINNHPYVSEDKRKRVFEAMESLE YTRNIHAVHLSKGFSNMIGVVLPTVNLPYFAELIAGIADAAAESGVHLSLFQTNYEVQ KEIFALSQLKQRQVDGLIFCSKALADEKLMEWEGPILLCQNSDNARFPTISIPHQEAF RNGLDYLIAKGHKKIAICLARKKGMNSHFRIKAYKEALEEIGEAFREDWVIEKAITIN DGKALFHKWNTWKEKPTAIFVANDQVSAGLFLEAKNQRVSVPDELAILSVDNHEISQA LGITTIDIQTREMGKQAFAILEKRIQGQPIERKVLDYRLIERSTV*" /label="ykvZ CDS" gene 1367392..1368357 /gene="ykvZ" /locus_tag="BSU_13870" /old_locus_tag="BSU13870" /label="ykvZ gene" promotor_-35 1368375..1368382 /Source="Nicolas_upshift_promotors" /id="U1135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.555444555444555" /psig="0.988011988011988" /xcortree=2551 /SigmaFactorBS="actgtttagtgaatgcattgaaaaaaGGTTTGACgtgcattc tgttcgTTATGTACGATATGAGGTATtgaatgacaaaggagctgaggatcgtgaatgg g" /listShort="glcT, S505" /listLong="ptsG, ptsH, ptsI, splA, splB" /label="promotor_-35" promotor_-10 1368397..1368416 /Source="Nicolas_upshift_promotors" /id="U1135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.555444555444555" /psig="0.988011988011988" /xcortree=2551 /SigmaFactorBS="actgtttagtgaatgcattgaaaaaaGGTTTGACgtgcattc tgttcgTTATGTACGATATGAGGTATtgaatgacaaaggagctgaggatcgtgaatgg g" /listShort="glcT, S505" /listLong="ptsG, ptsH, ptsI, splA, splB" /label="promotor_-10" upshifts 1368409 /Source="Nicolas_upshifts" /id="U1135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.555444555444555" /psig="0.988011988011988" /xcortree=2551 /SigmaFactorBS="actgtttagtgaatgcattgaaaaaaGGTTTGACgtgcattc tgttcgTTATGTACGATATGAGGTATtgaatgacaaaggagctgaggatcgtgaatgg g" /listShort="glcT, S505" /listLong="ptsG, ptsH, ptsI, splA, splB" /label="upshifts" CDS 1368420..1369286 /gene="glcT" /locus_tag="BSU_13880" /old_locus_tag="BSU13880" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10974121, 14527945, 15155854, 17074746, 22750856" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10974121, 14527945, 15155854, 17074746, 22750856; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional antiterminator (BglG family)" /protein_id="NP_389271.2" /db_xref="EnsemblGenomes-Gn:BSU13880" /db_xref="EnsemblGenomes-Tr:CAB13261" /db_xref="GOA:O31691" /db_xref="InterPro:IPR001550" /db_xref="InterPro:IPR004341" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR036634" /db_xref="InterPro:IPR036650" /db_xref="PDB:3GWH" /db_xref="PDB:3RIO" /db_xref="PDB:3UFE" /db_xref="SubtiList:BG12593" /db_xref="UniProtKB/Swiss-Prot:O31691" /translation="MTKELRIVNGSFTVKKVLNNNVLIASHHKYSEVVLIGKGIGFGK KQDDVIEDKGYDKMFILKDEKEQKQFKKLLDYVDEKLVDISNDVIYHISNRTNHSLNE HIHIALTDHIAFAIKRQQQGFDMKNPFLMETQSLYPEEYQIAKEVIDMINEKAGLCLP EGEIGFIALHIHSALTNRPLSEVNQHSQLMAQLVEVIEDSFQMKVNKESVNYLRLIRH IRFTIERIKKEEPTKEPEKLMLLLKNEYPLCYNTAWKLIKILQQTLKKPVHEAEAVYL TLHLYRLTNKIS*" /label="glcT CDS" gene 1368420..1369286 /gene="glcT" /locus_tag="BSU_13880" /old_locus_tag="BSU13880" /label="glcT gene" promotor_-35 1369141..1369145 /Source="Nicolas_upshift_promotors" /id="U1136" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.925074925074925" /psig=1 /xcortree=2686 /SigmaFactorBS="ccgactaaagaaccagaaaaattaatgttgtTATTGaaaaat gaatatccgcTATGCTACAATACAGCTTGGaaattgattaaaatcttgcagcaaacat t" /listShort="S505, ptsG, ptsH, ptsI, splA, splB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1369162..1369181 /Source="Nicolas_upshift_promotors" /id="U1136" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.925074925074925" /psig=1 /xcortree=2686 /SigmaFactorBS="ccgactaaagaaccagaaaaattaatgttgtTATTGaaaaat gaatatccgcTATGCTACAATACAGCTTGGaaattgattaaaatcttgcagcaaacat t" /listShort="S505, ptsG, ptsH, ptsI, splA, splB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1369170 /Source="Nicolas_upshifts" /id="U1136" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.925074925074925" /psig=1 /xcortree=2686 /SigmaFactorBS="ccgactaaagaaccagaaaaattaatgttgtTATTGaaaaat gaatatccgcTATGCTACAATACAGCTTGGaaattgattaaaatcttgcagcaaacat t" /listShort="S505, ptsG, ptsH, ptsI, splA, splB" /GFF_Attribute="listLong" /label="upshifts" downshifts 1369288 /Source="Nicolas_upshifts" /id="D773" /incds=0 /nref=1 /ntot=30 /MaxReadThrough="9.01653" /MaxDrop="3.09921" /score="-5.18621526" /energy="-6.2" /TU="U1133,U1135,U1136" /idTUdmin="U1135" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" misc_RNA 1369333..1369484 /gene="gswA" /locus_tag="BSU_misc_RNA_88" /product="riboswitch regulating ptsGHI expression via GlcTbinding" /experiment="publication(s) with functional evidences, PMID:15155854, 22750856" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15155854, 22750856; Product type n: RNA" /label="gswA RNA" S_feature 1369333..1369484 /Source="Nicolas_S_feature" /locus_tag="new_1457005_1457156" /HighExp="LBGexp, G150, C30, G135, G180, MG 90, dia0, Lbexp, dia15, GM-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 0.988, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S505" gene 1369333..1369484 /gene="gswA" /locus_tag="BSU_misc_RNA_88" /label="gswA gene" promotor_-35 1369462..1369468 /Source="Nicolas_upshift_promotors" /id="U1137" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.752247752247752" /psig="0.752247752247752" /xcortree=1446 /SigmaFactorBS="cggttaaactggaagacttacgcctgtgaattcgttGTCATG AtttttagctgtaaGGTCAGACTAGTaaaaagaggaggtcaattcttatgtttaaagc a" /listShort="ptsG, ptsH, ptsI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1369482..1369493 /Source="Nicolas_upshift_promotors" /id="U1137" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.752247752247752" /psig="0.752247752247752" /xcortree=1446 /SigmaFactorBS="cggttaaactggaagacttacgcctgtgaattcgttGTCATG AtttttagctgtaaGGTCAGACTAGTaaaaagaggaggtcaattcttatgtttaaagc a" /listShort="ptsG, ptsH, ptsI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1369486 /Source="Nicolas_upshifts" /id="U1137" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.752247752247752" /psig="0.752247752247752" /xcortree=1446 /SigmaFactorBS="cggttaaactggaagacttacgcctgtgaattcgttGTCATG AtttttagctgtaaGGTCAGACTAGTaaaaagaggaggtcaattcttatgtttaaagc a" /listShort="ptsG, ptsH, ptsI" /GFF_Attribute="listLong" /label="upshifts" CDS 1369515..1371614 /gene="ptsG" /locus_tag="BSU_13890" /old_locus_tag="BSU13890" /EC_number="2.7.1.199" /function="16.1: Circulate" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1447219, 8418852, 8432747, 9593197, 14527945, 15849754, 16850406, 22846916" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1447219, 8418852, 8432747, 9593197, 14527945, 15849754, 16850406, 22846916; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) glucose-specificenzyme IICBA component" /protein_id="NP_389272.1" /db_xref="EnsemblGenomes-Gn:BSU13890" /db_xref="EnsemblGenomes-Tr:CAB13262" /db_xref="GOA:P20166" /db_xref="InterPro:IPR001127" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR004719" /db_xref="InterPro:IPR011055" /db_xref="InterPro:IPR011299" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="PDB:1AX3" /db_xref="PDB:1GPR" /db_xref="SubtiList:BG10198" /db_xref="UniProtKB/Swiss-Prot:P20166" /translation="MFKALFGVLQKIGRALMLPVAILPAAGILLAIGNAMQNKDMIQV LHFLSNDNVQLVAGVMESAGQIVFDNLPLLFAVGVAIGLANGDGVAGIAAIIGYLVMN VSMSAVLLANGTIPSDSVERAKFFTENHPAYVNMLGIPTLATGVFGGIIVGVLAALLF NRFYTIELPQYLGFFAGKRFVPIVTSISALILGLIMLVIWPPIQHGLNAFSTGLVEAN PTLAAFIFGVIERSLIPFGLHHIFYSPFWYEFFSYKSAAGEIIRGDQRIFMAQIKDGV QLTAGTFMTGKYPFMMFGLPAAALAIYHEAKPQNKKLVAGIMGSAALTSFLTGITEPL EFSFLFVAPVLFAIHCLFAGLSFMVMQLLNVKIGMTFSGGLIDYFLFGILPNRTAWWL VIPVGLGLAVIYYFGFRFAIRKFNLKTPGREDAAEETAAPGKTGEAGDLPYEILQAMG DQENIKHLDACITRLRVTVNDQKKVDKDRLKQLGASGVLEVGNNIQAIFGPRSDGLKT QMQDIIAGRKPRPEPKTSAQEEVGQQVEEVIAEPLQNEIGEEVFVSPITGEIHPITDV PDQVFSGKMMGDGFAILPSEGIVVSPVRGKILNVFPTKHAIGLQSDGGREILIHFGID TVSLKGEGFTSFVSEGDRVEPGQKLLEVDLDAVKPNVPSLMTPIVFTNLAEGETVSIK ASGSVNREQEDIVKIEK*" /label="ptsG CDS" gene 1369515..1371614 /gene="ptsG" /locus_tag="BSU_13890" /old_locus_tag="BSU13890" /label="ptsG gene" promotor_-35 1371632..1371636 /Source="Nicolas_upshift_promotors" /id="U1138" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=2687 /SigmaFactorBS="attgaaaaataagggtgttagtacgccgtGCTTGtcagatga caagtacGGTTGTATGATATAATATTGtgaagtaataaagctttaagttaaaaggaga a" /listShort="ptsH, ptsI, splA, splB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1371652..1371671 /Source="Nicolas_upshift_promotors" /id="U1138" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=2687 /SigmaFactorBS="attgaaaaataagggtgttagtacgccgtGCTTGtcagatga caagtacGGTTGTATGATATAATATTGtgaagtaataaagctttaagttaaaaggaga a" /listShort="ptsH, ptsI, splA, splB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1371663 /Source="Nicolas_upshifts" /id="U1138" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=2687 /SigmaFactorBS="attgaaaaataagggtgttagtacgccgtGCTTGtcagatga caagtacGGTTGTATGATATAATATTGtgaagtaataaagctttaagttaaaaggaga a" /listShort="ptsH, ptsI, splA, splB" /GFF_Attribute="listLong" /label="upshifts" CDS 1371712..1371978 /gene="ptsH" /locus_tag="BSU_13900" /old_locus_tag="BSU13900" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10217795, 12411438, 14527945, 15126459, 16267306, 17085448, 17142398, 17726680, 20487301, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10217795, 12411438, 14527945, 15126459, 16267306, 17085448, 17142398, 17726680, 20487301, 25355936; Product type f: factor" /codon_start=1 /transl_table=11 /product="histidine-containing phosphocarrier protein of the phosphotransferase system (PTS) (HPr protein)" /protein_id="NP_389273.1" /db_xref="EnsemblGenomes-Gn:BSU13900" /db_xref="EnsemblGenomes-Tr:CAB13263" /db_xref="GOA:P08877" /db_xref="InterPro:IPR000032" /db_xref="InterPro:IPR001020" /db_xref="InterPro:IPR002114" /db_xref="InterPro:IPR035895" /db_xref="PDB:1JEM" /db_xref="PDB:1KKL" /db_xref="PDB:1KKM" /db_xref="PDB:1SPH" /db_xref="PDB:2FEP" /db_xref="PDB:2HID" /db_xref="PDB:2HPR" /db_xref="PDB:3OQM" /db_xref="PDB:3OQN" /db_xref="PDB:3OQO" /db_xref="SubtiList:BG10200" /db_xref="UniProtKB/Swiss-Prot:P08877" /translation="MAQKTFKVTADSGIHARPATVLVQTASKYDADVNLEYNGKTVNL KSIMGVMSLGIAKGAEITISASGADENDALNALEETMKSEGLGE*" /label="ptsH CDS" gene 1371712..1371978 /gene="ptsH" /locus_tag="BSU_13900" /old_locus_tag="BSU13900" /label="ptsH gene" CDS 1371978..1373690 /gene="ptsI" /locus_tag="BSU_13910" /old_locus_tag="BSU13910" /EC_number="2.7.3.9" /function="16.1: Circulate" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3106335, 11902727, 15155854, 15670601, 25355936, 26159071" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3106335, 11902727, 15155854, 15670601, 25355936, 26159071; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) enzyme I" /protein_id="NP_389274.2" /db_xref="EnsemblGenomes-Gn:BSU13910" /db_xref="EnsemblGenomes-Tr:CAB13264" /db_xref="GOA:P08838" /db_xref="InterPro:IPR000121" /db_xref="InterPro:IPR006318" /db_xref="InterPro:IPR008279" /db_xref="InterPro:IPR008731" /db_xref="InterPro:IPR015813" /db_xref="InterPro:IPR018274" /db_xref="InterPro:IPR023151" /db_xref="InterPro:IPR024692" /db_xref="InterPro:IPR036618" /db_xref="SubtiList:BG10201" /db_xref="UniProtKB/Swiss-Prot:P08838" /translation="MQELKGIGASAGIAIAKAYRLEEPDLTVEKKNISDSEAEVSRFD EAIARSKEELEKIKEHALKELGQDKADIFSAHLLVLSDPELLNPVKEKISTDSVNAEF ALKETSSMFVTMFESMDNEYMKERAADIRDVTKRVTGHLLGVEIPNPSMISEEVIIVA EDLTPSDTAQLNREFVKGFTTDIGGRTSHSAIMARSLEIPAVVGTKAATGTIQNGVTV IVDGINGDVIIDPSAETVKEYEEKHNAYLAQKAEWAKLVNEPTVSKDGHHVELAANIG TPDDVKGVLENGGEAVGLYRTEFLYMGRDQLPTEDEQFDAYKTVLERMEGKSVVVRTL DIGGDKELPYLQLPKEMNPFLGYRAIRLCLEEQEIFRTQLRALLRASTYGNLKIMFPM IATVNEFKEAKAILLEEKEKLVKAGQAVSDDIEVGMMVEIPSTAVIADQFAKEVDFFS IGTNDLIQYTMAADRMNERVSYLYQPYNPAILRLITLVIEAAHKEGKWVGMCGEMAGD EIAIPILLGLGLDEFSMSATSILPARTQISKLSKQEAESFKEKILSMSTTEEVVAFVK ETFK*" /label="ptsI CDS" gene 1371978..1373690 /gene="ptsI" /locus_tag="BSU_13910" /old_locus_tag="BSU13910" /label="ptsI gene" downshifts 1373677 /Source="Nicolas_upshifts" /id="D774" /incds=0 /nref=116 /ntot=277 /MaxReadThrough="5.0255" /MaxDrop="5.64321" /score="21.2608168" /energy="-12.3" /TU="U1136,U1138" /idTUdmin="U1133" /TUdmin=11 /isTUend="TRUE" /label="downshifts" promotor_-35 1373730..1373736 /Source="Nicolas_upshift_promotors" /id="U1139" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=850 /SigmaFactorBS="acaaaaaccagacggcctccggcctgtctggtttttTTCATA AgtaagggtatagaaGGACACAATAACatggctaggagggatagtatgtcaaaccaat t" /listShort="splA, splB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1373751..1373762 /Source="Nicolas_upshift_promotors" /id="U1139" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=850 /SigmaFactorBS="acaaaaaccagacggcctccggcctgtctggtttttTTCATA AgtaagggtatagaaGGACACAATAACatggctaggagggatagtatgtcaaaccaat t" /listShort="splA, splB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1373754 /Source="Nicolas_upshifts" /id="U1139" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=850 /SigmaFactorBS="acaaaaaccagacggcctccggcctgtctggtttttTTCATA AgtaagggtatagaaGGACACAATAACatggctaggagggatagtatgtcaaaccaat t" /listShort="splA, splB" /GFF_Attribute="listLong" /label="upshifts" CDS 1373781..1374020 /gene="splA" /locus_tag="BSU_13920" /old_locus_tag="BSU13920" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9009064, 9323362, 10629212" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9009064, 9323362, 10629212; Product type r: regulator" /codon_start=1 /transl_table=11 /product="TRAP-like transcriptional negative regulator of spore photoproduct lyase" /protein_id="NP_389275.1" /db_xref="EnsemblGenomes-Gn:BSU13920" /db_xref="EnsemblGenomes-Tr:CAB13265" /db_xref="GOA:P37955" /db_xref="InterPro:IPR022608" /db_xref="SubtiList:BG10202" /db_xref="UniProtKB/Swiss-Prot:P37955" /translation="MSNQFNAGDTVYVIYRNPHAANVAHIKEAEIVHHPYHEGELSLF IYETYHPFAEDDAVFASYEEAKSLYKELFDIDPYE*" /label="splA CDS" gene 1373781..1374020 /gene="splA" /locus_tag="BSU_13920" /old_locus_tag="BSU13920" /label="splA gene" S_feature complement(1373801..1375140) /Source="Nicolas_S_feature" /locus_tag="new_1461473_1462812_c" /HighExp="T4.0H, T3.30H, T3.0H, S3, S1, T2.0H, T2.30H, S2, T5.0H, S4" /AntisenseName="splB" /AntisenseCor="-0.193138593783996" /AntisenseRegPval="-2.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S506" CDS 1374098..1375126 /gene="splB" /locus_tag="BSU_13930" /old_locus_tag="BSU13930" /EC_number="4.1.99.14" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9733691, 10629212, 11053385, 11470912, 16829680, 16829676, 17293412, 18055591, 22197590, 22961846, 23607538, 24598744, 28027411" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9733691, 10629212, 11053385, 11470912, 16829680, 16829676, 17293412, 18055591, 22197590, 22961846, 23607538, 24598744, 28027411; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore photoproduct (thymine dimer) lyase" /protein_id="NP_389276.1" /db_xref="EnsemblGenomes-Gn:BSU13930" /db_xref="EnsemblGenomes-Tr:CAB13266" /db_xref="GOA:P37956" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR023897" /db_xref="InterPro:IPR034560" /db_xref="SubtiList:BG10203" /db_xref="UniProtKB/Swiss-Prot:P37956" /translation="MQNPFVPQLVYIEPRALEYPLGQELQDKFENMGIEIRETTSHNQ VRNIPGKNHLQQYRNAKSTLVIGVRKTLKFDSSKPSAEYAIPFATGCMGHCHYCYLQT TMGSKPYIRTYVNVEEILDQADKYMKERAPEFTRFEASCTSDIVGIDHLTHTLKRAIE HFGQSDLGKLRFVTKFHHVDHLLDAKHNGKTRFRFSINADYVIKNFEPGTSPLDKRIE AAVKVAKAGYPLGFIVAPIYIHEGWEEGYRHLFEKLDAALPQDVRHDITFELIQHRFT KPAKRVIEKNYPKTKLELDEEKRRYKWGRYGIGKYIYQKDEEHALREALESYIDTFFP NAKIEYFT*" /label="splB CDS" gene 1374098..1375126 /gene="splB" /locus_tag="BSU_13930" /old_locus_tag="BSU13930" /label="splB gene" downshifts 1375096 /Source="Nicolas_upshifts" /id="D775" /incds=0 /nref=5 /ntot=113 /MaxReadThrough="0.352" /MaxDrop="3.95383" /score="15.9223136" /energy="-13.2" /TU="NA" /idTUdmin="U1136" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1375141..1375821) /gene="ykwB" /locus_tag="BSU_13940" /old_locus_tag="BSU13940" /function="18.1: Enzymes of unknown specificity" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase / amidohydrolase" /protein_id="NP_389277.2" /db_xref="EnsemblGenomes-Gn:BSU13940" /db_xref="EnsemblGenomes-Tr:CAB13267" /db_xref="GOA:Q796K9" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG12252" /db_xref="UniProtKB/Swiss-Prot:Q796K9" /translation="MIILKQMYVHDGRKFEALTIRNYTETDIERLISLQEECFPPPFP QELLWSEDQLASHIKTFPEGALCALINGRIIGSMTALIVQFEPDSPDHTWAQATDNGS IKNHEPHGNTLYVVDISVSPHYRKLGIGKWLMNTMYELTVDKRLERLLGGGRIPLYYK YAHEISAVQYVEDVMEGRKNDPVLSFLLRCGRSPIRVVSNYLEDKESLNYGVLMEWKN VFYKKASC*" /label="ykwB CDS" gene complement(1375141..1375821) /gene="ykwB" /locus_tag="BSU_13940" /old_locus_tag="BSU13940" /label="ykwB gene" promotor_-10 complement(1375831..1375850) /Source="Nicolas_upshift_promotors" /id="U1140" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2873 /SigmaFactorBS="aaaatgaataatcaaaaaataaattataagaaaatcggaata TATTTACTgaaaattcaatcttCGTTATAATGAAACAACATAaggagagtgatgatca t" /listShort="ykwB, S506" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1375854) /Source="Nicolas_upshifts" /id="U1140" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2873 /SigmaFactorBS="aaaatgaataatcaaaaaataaattataagaaaatcggaata TATTTACTgaaaattcaatcttCGTTATAATGAAACAACATAaggagagtgatgatca t" /listShort="ykwB, S506" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1375865..1375872) /Source="Nicolas_upshift_promotors" /id="U1140" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2873 /SigmaFactorBS="aaaatgaataatcaaaaaataaattataagaaaatcggaata TATTTACTgaaaattcaatcttCGTTATAATGAAACAACATAaggagagtgatgatca t" /listShort="ykwB, S506" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1375906..1375913 /Source="Nicolas_upshift_promotors" /id="U1141" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2802 /SigmaFactorBS="tattccgattttcttataatttattttttgattATTCATTTt tcaaacgaaaggGCCGATATAGAAATTAGGAggggattggtttgtttaaaaaacttca c" /listShort="mcpC" /listLong="ykwC" /label="promotor_-35" promotor_-10 1375927..1375945 /Source="Nicolas_upshift_promotors" /id="U1141" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2802 /SigmaFactorBS="tattccgattttcttataatttattttttgattATTCATTTt tcaaacgaaaggGCCGATATAGAAATTAGGAggggattggtttgtttaaaaaacttca c" /listShort="mcpC" /listLong="ykwC" /label="promotor_-10" upshifts 1375933 /Source="Nicolas_upshifts" /id="U1141" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2802 /SigmaFactorBS="tattccgattttcttataatttattttttgattATTCATTTt tcaaacgaaaggGCCGATATAGAAATTAGGAggggattggtttgtttaaaaaacttca c" /listShort="mcpC" /listLong="ykwC" /label="upshifts" CDS 1375956..1377923 /gene="mcpC" /locus_tag="BSU_13950" /old_locus_tag="BSU13950" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:9721285, 11722727, 12603740, 15317802, 23038252, 27899502" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9721285, 11722727, 12603740, 15317802, 23038252, 27899502; Product type rc : receptor" /codon_start=1 /transl_table=11 /product="methyl-accepting chemotaxis protein" /protein_id="NP_389278.2" /db_xref="EnsemblGenomes-Gn:BSU13950" /db_xref="EnsemblGenomes-Tr:CAB13268" /db_xref="GOA:P54576" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033479" /db_xref="SubtiList:BG11533" /db_xref="UniProtKB/Swiss-Prot:P54576" /translation="MFKKLHMKIAVFVSIMLIITVVLLMLSSYLTLKPMITEDGKNTT QNVTQSLEQNIELQLKSYAISLSRLANGELTHTFVTKPSKEASRLFHDDIKQIKDNDD YVAMAYIGTAKKEMFTYPKADFAEDYDPTSRPWYKLAAETPDQVVWTEPYKDVVTGDM IVTASKAILDRQKVIGVASYDLKLSAIQSMVNKQKVPYKGFAFLADASGNLLAHPSNQ GKNISKDQTLQTIASEKKGIQDVNGKMVVYQTIGETGWKVGTQFDTDQLMWISDKMNR ANLWISLIALIITIILSYFLAKTITGPIQQLIVKTKAVSAGDLTVRAESKSKDEVGIL TRDFNLMVENMKEMVEQVRLSSGKVSDTSEQLTAVAAETNETSGQIAKAIEEVAAGAS EQASEVETINEKSESLSTKIRQIAEEAGGIKERSKSSEDASYKGLDALGQLLMKSNEA NMETKKVETMLLDLENQTKNIEEVVTAISNISDQTNLLALNASIEAARAGESGRGFAV VADEVRKLAEQSALSTKHISETVKLIQLETKEASHAMVEASRMNDEQNSAIHETGEVL NTITAEMQSLVQGIDHIYAEIQRMSEEQLAISEAIQSISAISQESAAAAEEVNASTDE QLVTLDKVKHSTETLKHASQELMNTIAKFTL*" /label="mcpC CDS" gene 1375956..1377923 /gene="mcpC" /locus_tag="BSU_13950" /old_locus_tag="BSU13950" /label="mcpC gene" misc_feature complement(1376396..1376411) /Source="Nicolas_upshift_promotors" /id="U1142" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.518481518481518" /psig="0.367632367632368" /xcortree=380 /SigmaFactorBS="cctgtctaagatcgctttcgatgcagtaacaatcatgtctcc tgtcacgacatctttATAAGGTTCCGTCCAAacaacttgatccggggtttcagctgca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1376408) /Source="Nicolas_upshifts" /id="U1142" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.518481518481518" /psig="0.367632367632368" /xcortree=380 /SigmaFactorBS="cctgtctaagatcgctttcgatgcagtaacaatcatgtctcc tgtcacgacatctttATAAGGTTCCGTCCAAacaacttgatccggggtttcagctgca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1377894 /Source="Nicolas_upshifts" /id="D776" /incds=0 /nref=134 /ntot=209 /MaxReadThrough="3.05506" /MaxDrop="5.75836" /score="24.6367658" /energy="-12.1" /TU="U1141" /idTUdmin="U1141" /TUdmin="-89" /isTUend="FALSE" /label="downshifts" promotor_-35 1377967..1377969 /Source="Nicolas_upshift_promotors" /id="U1143" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig=1 /xcortree=2290 /SigmaFactorBS="ccccaaacatcatttgttttggggattttttaTTTtataaga tgaatagaTATGGTAGTCTAGAAAATGAaggaaaaatgataaattttaactaaaatct a" /listShort="ykwC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1377985..1378004 /Source="Nicolas_upshift_promotors" /id="U1143" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig=1 /xcortree=2290 /SigmaFactorBS="ccccaaacatcatttgttttggggattttttaTTTtataaga tgaatagaTATGGTAGTCTAGAAAATGAaggaaaaatgataaattttaactaaaatct a" /listShort="ykwC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1377995 /Source="Nicolas_upshifts" /id="U1143" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig=1 /xcortree=2290 /SigmaFactorBS="ccccaaacatcatttgttttggggattttttaTTTtataaga tgaatagaTATGGTAGTCTAGAAAATGAaggaaaaatgataaattttaactaaaatct a" /listShort="ykwC" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(1378037) /Source="Nicolas_upshifts" /id="D777" /incds=0 /nref=1 /ntot=91 /MaxReadThrough="2.29647" /MaxDrop="4.49503" /score="37.1302416" /energy="-14.5" /TU="NA" /idTUdmin="U1144" /TUdmin=946 /isTUend="FALSE" /label="downshifts" CDS 1378061..1378927 /gene="ohaC" /locus_tag="BSU_13960" /old_locus_tag="BSU13960" /EC_number="1.1.1.60" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:20941576, 24390483" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20941576, 24390483; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="beta-hydroxyacid dehydrogenase (acts on 3-hydroxypropionate with NADP)" /protein_id="NP_389279.1" /db_xref="EnsemblGenomes-Gn:BSU13960" /db_xref="EnsemblGenomes-Tr:CAB13269" /db_xref="GOA:O34948" /db_xref="InterPro:IPR002204" /db_xref="InterPro:IPR006115" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR015815" /db_xref="InterPro:IPR029154" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13328" /db_xref="UniProtKB/Swiss-Prot:O34948" /translation="MKKTIGFIGLGVMGKSMASHILNDGHPVLVYTRTKEKAESILQK GAIWKDTVKDLSKEADVIITMVGYPSDVEEVYFGSNGIIENAKEGAYLIDMTTSKPSL AKKIAEAAKEKALFALDAPVSGGDIGAQNGTLAIMVGGEKEAFEACMPIFSLMGENIQ YQGPAGSGQHTKMCNQIAIAAGMIGVAEAMAYAQKSGLEPENVLKSITTGAAGSWSLS NLAPRMLQGNFEPGFYVKHFIKDMGIALEEAELMGEEMPGLSLAKSLYDKLAAQGEEN SGTQSIYKLWVK*" /label="ohaC CDS" gene 1378061..1378927 /gene="ohaC" /locus_tag="BSU_13960" /old_locus_tag="BSU13960" /label="ohaC gene" downshifts 1378907 /Source="Nicolas_upshifts" /id="D778" /incds=0 /nref=239 /ntot=266 /MaxReadThrough="2.14032" /MaxDrop="8.18847" /score="41.1703019" /energy="-14.5" /TU="NA" /idTUdmin="U1143" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1378966..1379739) /gene="ykwD" /locus_tag="BSU_13970" /old_locus_tag="BSU13970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389280.2" /db_xref="EnsemblGenomes-Gn:BSU13970" /db_xref="EnsemblGenomes-Tr:CAB13270" /db_xref="InterPro:IPR014044" /db_xref="InterPro:IPR014258" /db_xref="InterPro:IPR035940" /db_xref="SubtiList:BG13329" /db_xref="UniProtKB/Swiss-Prot:O31398" /translation="MKKAFILSAAAAVGLFTFGGVQQASAKELSCQPVVTVKTGNTVQ NMSLNDAVKKLHINTNIKTLNAANEKEMKQLLQKHAKQSNVKVQDVQKTETAKPAQKT TEKAAADQNTASKAPATAEKTNTTTSAPSSVSAYEKKVVELTNAERQKQGLKPLQIDE TLSKSARAKSQDMKDKNYFDHQSPTYGSPFDMMKSFGISYKTAGENIAKGQKTPEEVV KAWMNSEGHRKNILNPNFTHIGVGYVESGSIWTQQFIGK*" /label="ykwD CDS" gene complement(1378966..1379739) /gene="ykwD" /locus_tag="BSU_13970" /old_locus_tag="BSU13970" /label="ykwD gene" downshifts complement(1378983) /Source="Nicolas_upshifts" /id="D779" /incds=0 /nref=31 /ntot=168 /MaxReadThrough="1.32532" /MaxDrop="5.28625" /score="37.1302416" /energy="-14.5" /TU="NA" /idTUdmin="U1144" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(1379771..1379790) /Source="Nicolas_upshift_promotors" /id="U1144" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.711288711288711" /psig="0.994005994005994" /xcortree=2987 /SigmaFactorBS="acaatctctatttgtcaaaggaaagtgctggaatctttatga caaaaaagcTATGTTATGATTTTTCTGTAgaaacaaacaactctaggaggttacgaac t" /listShort="ykwD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1379781) /Source="Nicolas_upshifts" /id="U1144" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.711288711288711" /psig="0.994005994005994" /xcortree=2987 /SigmaFactorBS="acaatctctatttgtcaaaggaaagtgctggaatctttatga caaaaaagcTATGTTATGATTTTTCTGTAgaaacaaacaactctaggaggttacgaac t" /listShort="ykwD" /GFF_Attribute="listLong" /label="upshifts" misc_feature 1380014..1380033 /Source="Nicolas_upshift_promotors" /id="U1145" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.825174825174825" /psig="0.998001998001998" /xcortree=3175 /SigmaFactorBS="tattgacagctttttttactccttttcgctgtaacaactatt acaaaGGTGTTACAATTAATCTCAGtatatgtaaatatattgaatgatttgagagggg t" /listShort="S507, pbpH, kinA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1380027 /Source="Nicolas_upshifts" /id="U1145" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.825174825174825" /psig="0.998001998001998" /xcortree=3175 /SigmaFactorBS="tattgacagctttttttactccttttcgctgtaacaactatt acaaaGGTGTTACAATTAATCTCAGtatatgtaaatatattgaatgatttgagagggg t" /listShort="S507, pbpH, kinA" /GFF_Attribute="listLong" /label="upshifts" S_feature 1380029..1380132 /Source="Nicolas_S_feature" /locus_tag="new_1467701_1467804" /HighExp="T4.0H, T3.30H, T3.0H, Etha, T5.0H, T2.30H, LoTm, B60, T2.0H, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S507" CDS 1380076..1382190 /gene="pbpH" /locus_tag="BSU_13980" /old_locus_tag="BSU13980" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12896990, 23199363" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12896990, 23199363; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="penicillin-binding enzyme for formation of rod-shaped peptidoglycan cell wall" /protein_id="NP_389281.2" /db_xref="EnsemblGenomes-Gn:BSU13980" /db_xref="EnsemblGenomes-Tr:CAB13271" /db_xref="GOA:Q796K8" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR005311" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR036138" /db_xref="SubtiList:BG13286" /db_xref="UniProtKB/Swiss-Prot:Q796K8" /translation="MTEIGREPKKKSKGNRAIRMNLFFLAVFVLFTALIFKLGVVQIV EGEQHEEDAEKSNAKTAYYPAPRGKMYDRNQKVAVDNQSVPEIVYVSTSSTKTEDKIK TAKRLASFIHIDTEFLKERDLRDYWIAAHPKKAAALLKESESNLKGDQAYKLQIERVP DQELKAIQQDDEEMETAAIYTRFSSGNAYEPQIVKAMNPNKSNSNGKNGALLDEKKNS SQRPKNDLTYDEISIVSEHLEELPGIDIVNDWTRKYPYDKTLYSVFGGVTTPDQGLLS DRKDFYLTRGYANNDRVGKSYLEYQYEEYLNSHKEKVEYVEDNKGNVVSQKTIDKGSR GYDLQLSFDMELQAKVEKIIEEEVRNSRARGNYMLDRAFAVMMDPNNGDILSMAGKKI DLKTNKIEDYAIGAFTTQYEMGSAVKGATVLAGYQDGIPHYKYYIDAPMLLGTNLIKK SYTNMGTINELTALQKSSNVYMFNVAMHIAGVTYKPHGSLPADQNDLLKMRNYYSQFG LGVKTGIDLPQESAGMQTTPKTVGGLILDLAIGQYDTYTPLQMAQYISVIANGGYRVQ PRIVTSIHKPGKKDQLGKAIEHRKPKVLNKINNSESDLKQVQTGMKLVTSSGTAKNTF TEDVSGKTGTAETFYYGTNRNWWGKKTYNLTFVGYYPSKKPKVAFSVVVPSVDDDDKI NKIIAKRAIHAYAELEKKHSKK*" /label="pbpH CDS" gene 1380076..1382190 /gene="pbpH" /locus_tag="BSU_13980" /old_locus_tag="BSU13980" /label="pbpH gene" promotor_-10 complement(1381369..1381387) /Source="Nicolas_upshift_promotors" /id="U1146" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.836163836163836" /psig="0.836163836163836" /xcortree=778 /SigmaFactorBS="ccatattagtataagatttttttataagattcgTTCCTAaaa gcattggagcatCGATATAATATTTATAATGcgggatcccgtcctgatagccggctag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1381381) /Source="Nicolas_upshifts" /id="U1146" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.836163836163836" /psig="0.836163836163836" /xcortree=778 /SigmaFactorBS="ccatattagtataagatttttttataagattcgTTCCTAaaa gcattggagcatCGATATAATATTTATAATGcgggatcccgtcctgatagccggctag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1381403..1381408) /Source="Nicolas_upshift_promotors" /id="U1146" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.836163836163836" /psig="0.836163836163836" /xcortree=778 /SigmaFactorBS="ccatattagtataagatttttttataagattcgTTCCTAaaa gcattggagcatCGATATAATATTTATAATGcgggatcccgtcctgatagccggctag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1382171 /Source="Nicolas_upshifts" /id="D780" /incds=0 /nref=139 /ntot=246 /MaxReadThrough="3.36066" /MaxDrop="5.01597" /score="-1.2500858" /energy="-12" /TU="U1145" /idTUdmin="U1145" /TUdmin="-1862" /isTUend="FALSE" /label="downshifts" promotor_-35 1382263..1382271 /Source="Nicolas_upshift_promotors" /id="U1147" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=554 /SigmaFactorBS="tcaaaaattgacgttcaccataagaataGAAGGAGAAtactc attttcTAGCGAATCATACTAGGTAaaagtcaatctgtatatgtcgaaacacgatgat c" /listShort="kinA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1382283..1382301 /Source="Nicolas_upshift_promotors" /id="U1147" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=554 /SigmaFactorBS="tcaaaaattgacgttcaccataagaataGAAGGAGAAtactc attttcTAGCGAATCATACTAGGTAaaagtcaatctgtatatgtcgaaacacgatgat c" /listShort="kinA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1382295 /Source="Nicolas_upshifts" /id="U1147" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=554 /SigmaFactorBS="tcaaaaattgacgttcaccataagaataGAAGGAGAAtactc attttcTAGCGAATCATACTAGGTAaaagtcaatctgtatatgtcgaaacacgatgat c" /listShort="kinA" /GFF_Attribute="listLong" /label="upshifts" CDS 1382354..1384174 /gene="kinA" /locus_tag="BSU_13990" /old_locus_tag="BSU13990" /EC_number="2.7.13.3" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11734624, 14629015, 17350039, 21097618, 22303282, 23169620, 23378509, 23504013, 26712348, 28449380" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11734624, 14629015, 17350039, 21097618, 22303282, 23169620, 23378509, 23504013, 26712348, 28449380; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sporulation-specific ATP-dependent protein histidine kinase" /protein_id="NP_389282.1" /db_xref="EnsemblGenomes-Gn:BSU13990" /db_xref="EnsemblGenomes-Tr:CAB13272" /db_xref="GOA:P16497" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR001610" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR013655" /db_xref="InterPro:IPR013767" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="PDB:2VLG" /db_xref="SubtiList:BG10204" /db_xref="UniProtKB/Swiss-Prot:P16497" /translation="MEQDTQHVKPLQTKTDIHAVLASNGRIIYISANSKLHLGYLQGE MIGSFLKTFLHEEDQFLVESYFYNEHHLMPCTFRFIKKDHTIVWVEAAVEIVTTRAER TEREIILKMKVLEEETGHQSLNCEKHEIEPASPESTTYITDDYERLVENLPSPLCISV KGKIVYVNSAMLSMLGAKSKDAIIGKSSYEFIEEEYHDIVKNRIIRMQKGMEVGMIEQ TWKRLDGTPVHLEVKASPTVYKNQQAELLLLIDISSRKKFQTILQKSRERYQLLIQNS IDTIAVIHNGKWVFMNESGISLFEAATYEDLIGKNIYDQLHPCDHEDVKERIQNIAEQ KTESEIVKQSWFTFQNRVIYTEMVCIPTTFFGEAAVQVILRDISERKQTEELMLKSEK LSIAGQLAAGIAHEIRNPLTAIKGFLQLMKPTMEGNEHYFDIVFSELSRIELILSELL MLAKPQQNAVKEYLNLKKLIGEVSALLETQANLNGIFIRTSYEKDSIYINGDQNQLKQ VFINLIKNAVESMPDGGTVDIIITEDEHSVHVTVKDEGEGIPEKVLNRIGEPFLTTKE KGTGLGLMVTFNIIENHQGVIHVDSHPEKGTAFKISFPKK*" /label="kinA CDS" gene 1382354..1384174 /gene="kinA" /locus_tag="BSU_13990" /old_locus_tag="BSU13990" /label="kinA gene" CDS complement(1384185..1385366) /gene="dapX" /locus_tag="BSU_14000" /old_locus_tag="BSU14000" /EC_number="2.6.1.83" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12670965, 14523133, 14627808, 19948795" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12670965, 14523133, 14627808, 19948795; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetyl-L,L-diaminopimelate aminotransferase" /protein_id="NP_389283.2" /db_xref="EnsemblGenomes-Gn:BSU14000" /db_xref="EnsemblGenomes-Tr:CAB13273" /db_xref="GOA:P16524" /db_xref="InterPro:IPR004838" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG10205" /db_xref="UniProtKB/Swiss-Prot:P16524" /translation="MEHLLNPKAREIEISGIRKFSNLVAQHEDVISLTIGQPDFFTPH HVKAAAKKAIDENVTSYTPNAGYLELRQAVQLYMKKKADFNYDAESEIIITTGASQAI DAAFRTILSPGDEVIMPGPIYPGYEPIINLCGAKPVIVDTTSHGFKLTARLIEDALTP NTKCVVLPYPSNPTGVTLSEEELKSIAALLKGRNVFVLSDEIYSELTYDRPHYSIATY LRDQTIVINGLSKSHSMTGWRIGFLFAPKDIAKHILKVHQYNVSCASSISQKAALEAV TNGFDDALIMREQYKKRLDYVYDRLVSMGLDVVKPSGAFYIFPSIKSFGMTSFDFSMA LLEDAGVALVPGSSFSTYGEGYVRLSFACSMDTLREGLDRLELFVLKKREAMQTINNG V*" /label="dapX CDS" gene complement(1384185..1385366) /gene="dapX" /locus_tag="BSU_14000" /old_locus_tag="BSU14000" /label="dapX gene" downshifts complement(1384219) /Source="Nicolas_upshifts" /id="D781" /incds=0 /nref=255 /ntot=267 /MaxReadThrough="1.89632" /MaxDrop="6.70715" /score="-6.17975559" /energy="-4.7" /TU="NA" /idTUdmin="U1148" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(1385394..1385413) /Source="Nicolas_upshift_promotors" /id="U1148" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.928071928071928" /psig=1 /xcortree=1466 /SigmaFactorBS="gaaaaaaggcgcatacaatcgaaatatatcagttaaaaaggt gacaaatgatcagctAGTGGTAAAATAGGATAAACtcattatatttgttaaggtgatg a" /listShort="patA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1385410) /Source="Nicolas_upshifts" /id="U1148" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.928071928071928" /psig=1 /xcortree=1466 /SigmaFactorBS="gaaaaaaggcgcatacaatcgaaatatatcagttaaaaaggt gacaaatgatcagctAGTGGTAAAATAGGATAAACtcattatatttgttaaggtgatg a" /listShort="patA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1385442..1385460) /Source="Nicolas_upshift_promotors" /id="U1149" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1170 /SigmaFactorBS="atcgctggttgtcttctttttttctgaaaagaaaGGTATGtt tagaaaaaaggcGCATACAATCGAAATATATcagttaaaaaggtgacaaatgatcagc t" /listShort="patA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1385454) /Source="Nicolas_upshifts" /id="U1149" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1170 /SigmaFactorBS="atcgctggttgtcttctttttttctgaaaagaaaGGTATGtt tagaaaaaaggcGCATACAATCGAAATATATcagttaaaaaggtgacaaatgatcagc t" /listShort="patA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1385456..1385524) /Source="Nicolas_S_feature" /locus_tag="new_1473128_1473196_c" /HighExp="M9-stat, Lbtran, Lbstat, T3.30H, T3.0H, T2.30H, M0t90, T4.0H, M40t90, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S508" promotor_-35 complement(1385475..1385480) /Source="Nicolas_upshift_promotors" /id="U1149" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1170 /SigmaFactorBS="atcgctggttgtcttctttttttctgaaaagaaaGGTATGtt tagaaaaaaggcGCATACAATCGAAATATATcagttaaaaaggtgacaaatgatcagc t" /listShort="patA" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1385518..1385537) /Source="Nicolas_upshift_promotors" /id="U1150" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=3165 /SigmaFactorBS="ttgattatggctattaatgaaattggcacatataaacaataa tagaaCATGATACAATAAAGACAATcaaatcgctggttgtcttctttttttctgaaaa g" /listShort="S508, patA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1385524) /Source="Nicolas_upshifts" /id="U1150" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=3165 /SigmaFactorBS="ttgattatggctattaatgaaattggcacatataaacaataa tagaaCATGATACAATAAAGACAATcaaatcgctggttgtcttctttttttctgaaaa g" /listShort="S508, patA" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1385568..1385729) /gene="ykzT" /locus_tag="BSU_14009" /old_locus_tag="BSU14009" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097722.1" /db_xref="EnsemblGenomes-Gn:BSU14009" /db_xref="EnsemblGenomes-Tr:CAX52613" /db_xref="UniProtKB/Swiss-Prot:C0H406" /translation="MGTLVIFKENEMTVLEDISEETYLNMKKESADLQEEHPPYLIWH EDLHFDYGY*" /label="ykzT CDS" gene complement(1385568..1385729) /gene="ykzT" /locus_tag="BSU_14009" /old_locus_tag="BSU14009" /label="ykzT gene" promotor_-10 complement(1385752..1385771) /Source="Nicolas_upshift_promotors" /id="U1151" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.702297702297702" /psig=1 /xcortree=2406 /SigmaFactorBS="gttcctcaaaaaagaaacttttttcctaataacCATTGACTt tccaactaacagTGATAAAATAGTCAAGGATTtttccaaagaagggtgtaaataatgg g" /listShort="ykzT, S508, patA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1385765) /Source="Nicolas_upshifts" /id="U1151" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.702297702297702" /psig=1 /xcortree=2406 /SigmaFactorBS="gttcctcaaaaaagaaacttttttcctaataacCATTGACTt tccaactaacagTGATAAAATAGTCAAGGATTtttccaaagaagggtgtaaataatgg g" /listShort="ykzT, S508, patA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1385785..1385792) /Source="Nicolas_upshift_promotors" /id="U1151" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.702297702297702" /psig=1 /xcortree=2406 /SigmaFactorBS="gttcctcaaaaaagaaacttttttcctaataacCATTGACTt tccaactaacagTGATAAAATAGTCAAGGATTtttccaaagaagggtgtaaataatgg g" /listShort="ykzT, S508, patA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1385866..1385873 /Source="Nicolas_upshift_promotors" /id="U1152" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2811 /SigmaFactorBS="cgcggcttgttgccttcggaattcgattttgaagagctgccA TTCACTTtttacaaattacGCCGATATATACAGTACAAtactgaatgcgaatagcgag g" /listShort="cheV" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1385885 /Source="Nicolas_upshifts" /id="U1152" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2811 /SigmaFactorBS="cgcggcttgttgccttcggaattcgattttgaagagctgccA TTCACTTtttacaaattacGCCGATATATACAGTACAAtactgaatgcgaatagcgag g" /listShort="cheV" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1385886..1385904 /Source="Nicolas_upshift_promotors" /id="U1152" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2811 /SigmaFactorBS="cgcggcttgttgccttcggaattcgattttgaagagctgccA TTCACTTtttacaaattacGCCGATATATACAGTACAAtactgaatgcgaatagcgag g" /listShort="cheV" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1385933..1386844 /gene="cheV" /locus_tag="BSU_14010" /old_locus_tag="BSU14010" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11553614, 12864845, 14731274, 14993307, 26844549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11553614, 12864845, 14731274, 14993307, 26844549; Product type r: regulator" /codon_start=1 /transl_table=11 /product="coupling protein and response regulator for CheAactivity in response to attractants (chemotaxis)" /protein_id="NP_389284.1" /db_xref="EnsemblGenomes-Gn:BSU14010" /db_xref="EnsemblGenomes-Tr:CAB13274" /db_xref="GOA:P37599" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR002545" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR024181" /db_xref="InterPro:IPR036061" /db_xref="SubtiList:BG10823" /db_xref="UniProtKB/Swiss-Prot:P37599" /translation="MSLQQYEILLDSGTNELEIVKFGVGENAFGINVMKVREIIQPVE VTSVPHSHQHVEGMIKLRGEILPVISLFSFFGVEPEGSKDEKYIVTEFNKRKIVFHVG SVSQIHRVSWEAIEKPTSLNQGMERHLTGIIKLEDLMIFLPDYEKIIYDIESDSGVDT YNMHTEGFDERRTDKKLIIVEDSPLLMRLLQDELKEAGYNNIASFENGKEAYEYIMNL AENETDLSKQIDMIITDIEMPKMDGHRLTKLLKENPKSSDVPVMIFSSLITDDLRHRG EVVGADEQISKPEISDLIKKVDTYVIE*" /label="cheV CDS" gene 1385933..1386844 /gene="cheV" /locus_tag="BSU_14010" /old_locus_tag="BSU14010" /label="cheV gene" downshifts complement(1385938) /Source="Nicolas_upshifts" /id="D782" /incds=0 /nref=1 /ntot=50 /MaxReadThrough="1.14523" /MaxDrop="3.62759" /score="-8.29055697" /energy="-7.7" /TU="NA" /idTUdmin="U1154" /TUdmin=968 /isTUend="FALSE" /label="downshifts" promotor_-35 1386387..1386395 /Source="Nicolas_upshift_promotors" /id="U1153" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.54045954045954" /psig="0.54045954045954" /xcortree=750 /SigmaFactorBS="ctttttgcctgactatgaaaaaattatttatgacaTTGAATC AGattcaggtgttgaCACGTATAATATGCATACcgagggcttcgatgaaagaagaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1386409..1386426 /Source="Nicolas_upshift_promotors" /id="U1153" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.54045954045954" /psig="0.54045954045954" /xcortree=750 /SigmaFactorBS="ctttttgcctgactatgaaaaaattatttatgacaTTGAATC AGattcaggtgttgaCACGTATAATATGCATACcgagggcttcgatgaaagaagaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1386412 /Source="Nicolas_upshifts" /id="U1153" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.54045954045954" /psig="0.54045954045954" /xcortree=750 /SigmaFactorBS="ctttttgcctgactatgaaaaaattatttatgacaTTGAATC AGattcaggtgttgaCACGTATAATATGCATACcgagggcttcgatgaaagaagaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1386829 /Source="Nicolas_upshifts" /id="D783" /incds=0 /nref=188 /ntot=251 /MaxReadThrough="4.61331" /MaxDrop="6.23797" /score="15.4598573" /energy="-13.1" /TU="U1152" /idTUdmin="U1153" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1386888..1387352) /gene="kre" /locus_tag="BSU_14020" /old_locus_tag="BSU14020" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of transcription factor ComK function via modulation of mRNA stability" /protein_id="NP_389285.1" /db_xref="EnsemblGenomes-Gn:BSU14020" /db_xref="EnsemblGenomes-Tr:CAB13275" /db_xref="InterPro:IPR025552" /db_xref="SubtiList:BG11202" /db_xref="UniProtKB/Swiss-Prot:P42430" /translation="MDDHAYTKDLQPTVENLSKAVYTVNRHAKTAPNPKYLYLLKKRA LQKLVKEGKGKKIGLHFSKNPRFSQQQSDVLISIGDYYFHMPPTKEDFEHLPHLGTLN QSYRNPKAQMSLTKAKHLLQEYVGMKEKPLVPNRQQPAYHKPVFKKLGESYF*" /label="kre CDS" gene complement(1386888..1387352) /gene="kre" /locus_tag="BSU_14020" /old_locus_tag="BSU14020" /label="kre gene" downshifts complement(1386906) /Source="Nicolas_upshifts" /id="D784" /incds=0 /nref=212 /ntot=260 /MaxReadThrough="2.67186" /MaxDrop="6.66359" /score="16.1985615" /energy="-13.1" /TU="NA" /idTUdmin="U1154" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1387382..1387401) /Source="Nicolas_upshift_promotors" /id="U1154" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.878121878121878" /psig="0.99100899100899" /xcortree=2996 /SigmaFactorBS="cttagaaaaaagcgcatttttacattcaaTATTTGCAtttca actttaaaaAAGTATAATCTAAACATATAgaaattgataagagcaaaggagagaaata a" /listShort="ykyB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1387392) /Source="Nicolas_upshifts" /id="U1154" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.878121878121878" /psig="0.99100899100899" /xcortree=2996 /SigmaFactorBS="cttagaaaaaagcgcatttttacattcaaTATTTGCAtttca actttaaaaAAGTATAATCTAAACATATAgaaattgataagagcaaaggagagaaata a" /listShort="ykyB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1387416..1387423) /Source="Nicolas_upshift_promotors" /id="U1154" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.878121878121878" /psig="0.99100899100899" /xcortree=2996 /SigmaFactorBS="cttagaaaaaagcgcatttttacattcaaTATTTGCAtttca actttaaaaAAGTATAATCTAAACATATAgaaattgataagagcaaaggagagaaata a" /listShort="ykyB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1387478..1388770) /gene="ykuC" /locus_tag="BSU_14030" /old_locus_tag="BSU14030" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_389286.2" /db_xref="EnsemblGenomes-Gn:BSU14030" /db_xref="EnsemblGenomes-Tr:CAB13276" /db_xref="GOA:O31695" /db_xref="InterPro:IPR004751" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13287" /db_xref="UniProtKB/Swiss-Prot:O31695" /translation="MDIFKNRNFVRLFFAALASQMGTTVGNMAFAFFLLDRFSSQPSY TTLAELMYSLPTIFVFLIVGVVADRFDRKKVAENCDWIRAGLTVVLFFTLFTGNIPLV FCILFIRSAVTKFFFPAENSLVQAILPKEHYAKAAGLNQMLFSIFMVFGVGIGAFMYN TIGIEGAIILDFVSFIISGLLIRSCRIPKEARQPNGAFSWRKTSVKDSINDFREGILY ILKNKLLASLIFGFFIFGFVNGGFAVLPMFTMKYGLAPDRYEWHTSVFTIALGFGLLA GSVIGTLISKKVKPHFLMSIPIFIAGLLIFVLGYTNILWVYYAAAFALGMCIGPINIA IGGWMPKIVHPKLMGRVSGMQDPFMMFAQSLTLGLVALLFPKFVSNIDYLYYGMGVII LLVFIFYFIALPKYSAQAVEVNVQEAFQEQPKKKARSV*" /label="ykuC CDS" gene complement(1387478..1388770) /gene="ykuC" /locus_tag="BSU_14030" /old_locus_tag="BSU14030" /label="ykuC gene" downshifts complement(1387500) /Source="Nicolas_upshifts" /id="D785" /incds=0 /nref=37 /ntot=206 /MaxReadThrough="4.24449" /MaxDrop="4.31411" /score="3.5676583" /energy="-14.2" /TU="U1155" /idTUdmin="U1156" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1388794..1388813) /Source="Nicolas_upshift_promotors" /id="U1155" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.831168831168831" /psig="0.997002997002997" /xcortree=1817 /SigmaFactorBS="gattaaccggtaatgttttcttattTGTTTcaaaaacaggcg gttTATAATATGATAAAGTGGGAcctttagggtaaggagcgtttttatggatatattt a" /listShort="ykuC" /listLong="ykyB" /label="promotor_-10" upshifts complement(1388798) /Source="Nicolas_upshifts" /id="U1155" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.831168831168831" /psig="0.997002997002997" /xcortree=1817 /SigmaFactorBS="gattaaccggtaatgttttcttattTGTTTcaaaaacaggcg gttTATAATATGATAAAGTGGGAcctttagggtaaggagcgtttttatggatatattt a" /listShort="ykuC" /listLong="ykyB" /label="upshifts" promotor_-35 complement(1388829..1388833) /Source="Nicolas_upshift_promotors" /id="U1155" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.831168831168831" /psig="0.997002997002997" /xcortree=1817 /SigmaFactorBS="gattaaccggtaatgttttcttattTGTTTcaaaaacaggcg gttTATAATATGATAAAGTGGGAcctttagggtaaggagcgtttttatggatatattt a" /listShort="ykuC" /listLong="ykyB" /label="promotor_-35" CDS complement(1388846..1389340) /gene="ltdD" /locus_tag="BSU_14040" /old_locus_tag="BSU14040" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11011148, 16287140, 23832002" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11011148, 16287140, 23832002; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="murein L,D-transpeptidase" /protein_id="NP_389287.1" /db_xref="EnsemblGenomes-Gn:BSU14040" /db_xref="EnsemblGenomes-Tr:CAB13277" /db_xref="GOA:O34816" /db_xref="InterPro:IPR005490" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="PDB:1Y7M" /db_xref="PDB:2MTZ" /db_xref="PDB:3ZQD" /db_xref="PDB:4A1I" /db_xref="PDB:4A1J" /db_xref="PDB:4A1K" /db_xref="PDB:4A52" /db_xref="SubtiList:BG13288" /db_xref="UniProtKB/Swiss-Prot:O34816" /translation="MLTYQVKQGDTLNSIAADFRISTAALLQANPSLQAGLTAGQSIV IPGLPDPYTIPYHIAVSIGAKTLTLSLNNRVMKTYPIAVGKILTQTPTGEFYIINRQR NPGGPFGAYWLSLSKQHYGIHGTNNPASIGKAVSKGCIRMHNKDVIELASIVPNGTRV TINR*" /label="ltdD CDS" gene complement(1388846..1389340) /gene="ltdD" /locus_tag="BSU_14040" /old_locus_tag="BSU14040" /label="ltdD gene" promotor_-10 complement(1389356..1389375) /Source="Nicolas_upshift_promotors" /id="U1156" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1309 /SigmaFactorBS="gaaatcactgtcttcaccttaaaaagcacaaattAATGTAGC AGgatgggctcctcaTCAATACTTATAAGTAAAAAaggaggatgaggaaactgcttac g" /listShort="ykuD, ykuC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1389372) /Source="Nicolas_upshifts" /id="U1156" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1309 /SigmaFactorBS="gaaatcactgtcttcaccttaaaaagcacaaattAATGTAGC AGgatgggctcctcaTCAATACTTATAAGTAAAAAaggaggatgaggaaactgcttac g" /listShort="ykuD, ykuC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1389389..1389398) /Source="Nicolas_upshift_promotors" /id="U1156" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1309 /SigmaFactorBS="gaaatcactgtcttcaccttaaaaagcacaaattAATGTAGC AGgatgggctcctcaTCAATACTTATAAGTAAAAAaggaggatgaggaaactgcttac g" /listShort="ykuD, ykuC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1389397..1390257) /gene="ppeE" /locus_tag="BSU_14050" /old_locus_tag="BSU14050" /EC_number="3.1.-.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:22767609, 24140208" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22767609, 24140208; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported metallophosphoesterase (Mn2+ and Zn2+)" /protein_id="NP_389288.2" /db_xref="EnsemblGenomes-Gn:BSU14050" /db_xref="EnsemblGenomes-Tr:CAB13278" /db_xref="GOA:O34870" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR006311" /db_xref="InterPro:IPR019546" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG13289" /db_xref="UniProtKB/Swiss-Prot:O34870" /translation="MKKMSRRQFLKGMFGALAAGALTAGGGYGYARYLEPHMIETTEH TIKSSLIPHGFDGFKIVQFSDAHLSDYFTLEDLKTVILTINESKPDLIVFTGDIIDNP DTYQHHQAVIPLLRKLNAPFGKLCIYGNHDHGGYGTAVYKSLMTAGGFTVYRNGYQTL SLADGSKIEIASLDDLMLGNPDYEGTLSRLSDRLFSILLVHEPDAALKTTDYPVNLQL SGHTHGGQIQLPFYGPIITPPYGKVYTEGMYQTGSTHIYVNRGLGMTRLPLRFLAKPE ITVFTLKSTN*" /label="ppeE CDS" gene complement(1389397..1390257) /gene="ppeE" /locus_tag="BSU_14050" /old_locus_tag="BSU14050" /label="ppeE gene" misc_feature complement(1390278..1390297) /Source="Nicolas_upshift_promotors" /id="U1157" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.885114885114885" /psig="0.997002997002997" /xcortree=1947 /SigmaFactorBS="attatatccctgcctctgtcagcacatgctcatatgagattt ttatcagatacaGATGATATAATAGAAAAACTctattaaaggttggtttgaaatgaaa a" /listShort="ykuE, ykuD" /listLong="ykuC, ykyB" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1390291) /Source="Nicolas_upshifts" /id="U1157" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.885114885114885" /psig="0.997002997002997" /xcortree=1947 /SigmaFactorBS="attatatccctgcctctgtcagcacatgctcatatgagattt ttatcagatacaGATGATATAATAGAAAAACTctattaaaggttggtttgaaatgaaa a" /listShort="ykuE, ykuD" /listLong="ykuC, ykyB" /label="upshifts" promotor_-35 1390328..1390335 /Source="Nicolas_upshift_promotors" /id="U1158" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.781218781218781" /psig="0.97002997002997" /xcortree=404 /SigmaFactorBS="tgataaaaatctcatatgagcatgTGCTGACAgaggcaggga tataaTGATAGAATATTATTGAATGaataatcattcacaattggagggataaacatgg a" /listShort="fadH, S509, S510, fadG, ykzU, ykuH" /listLong="S511, ykuI" /label="promotor_-35" promotor_-10 1390351..1390370 /Source="Nicolas_upshift_promotors" /id="U1158" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.781218781218781" /psig="0.97002997002997" /xcortree=404 /SigmaFactorBS="tgataaaaatctcatatgagcatgTGCTGACAgaggcaggga tataaTGATAGAATATTATTGAATGaataatcattcacaattggagggataaacatgg a" /listShort="fadH, S509, S510, fadG, ykzU, ykuH" /listLong="S511, ykuI" /label="promotor_-10" upshifts 1390364 /Source="Nicolas_upshifts" /id="U1158" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.781218781218781" /psig="0.97002997002997" /xcortree=404 /SigmaFactorBS="tgataaaaatctcatatgagcatgTGCTGACAgaggcaggga tataaTGATAGAATATTATTGAATGaataatcattcacaattggagggataaacatgg a" /listShort="fadH, S509, S510, fadG, ykzU, ykuH" /listLong="S511, ykuI" /label="upshifts" CDS 1390400..1391164 /gene="fadH" /locus_tag="BSU_14060" /old_locus_tag="BSU14060" /EC_number="1.3.1.34" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 2,4-dienoyl-CoA reductase" /protein_id="NP_389289.1" /db_xref="EnsemblGenomes-Gn:BSU14060" /db_xref="EnsemblGenomes-Tr:CAB13279" /db_xref="GOA:O34717" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13290" /db_xref="UniProtKB/Swiss-Prot:O34717" /translation="MEKKAVIITGGSSGMGKAMAKKQAELGWHVMVTGRNHEALEETK KEIQTFEGQVACFQMDVRSDSAASDMIKEAVKAFGRLDALINNAAGNFICPAEKLTPN GWKAVIEIVLNGTFFCSQAAARHWIDQKQQGVILNMAATYAWGAGAGVVHSAAAKAGV LSLTRTLAVEWGSKYGIRTNAIAPGPIERTGGAEKLFESEKAMARTMNSVPLGRLGTP EEIAALAAFLLSDEASYINGDCITMDGGQWLNPYPF*" /label="fadH CDS" gene 1390400..1391164 /gene="fadH" /locus_tag="BSU_14060" /old_locus_tag="BSU14060" /label="fadH gene" S_feature 1391165..1391313 /Source="Nicolas_S_feature" /locus_tag="new_1478837_1478985" /HighExp="T0.30H, T1.0H, B60, Sw, BC, LoTm, M9-stat, S8, S7, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.97" /TUlongSig="NA" /TUlongPSig="NA" /label="S509" misc_feature 1391294..1391312 /Source="Nicolas_upshift_promotors" /id="U1159" /multdbtbs="-" /comp="M12" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=1521 /SigmaFactorBS="tgataacacatagagctttatttgtttatgaggtgttgtGTC ATACGTAAGCCACCTAatatatgaaaggtatattttaaaaggggagacgaaatatgaa g" /listShort="S510, fadG, ykzU, ykuH, S511, ykuI, S512" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1391315..1391464 /Source="Nicolas_S_feature" /locus_tag="new_1478987_1479136" /HighExp="T0.30H, M40t90, T1.0H, B60, BC, Sw, LPh, LoTm, M9-stat, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0, 0.97" /TUlongSig="NA" /TUlongPSig="NA" /label="S510" upshifts 1391315 /Source="Nicolas_upshifts" /id="U1159" /multdbtbs="-" /comp="M12" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=1521 /SigmaFactorBS="tgataacacatagagctttatttgtttatgaggtgttgtGTC ATACGTAAGCCACCTAatatatgaaaggtatattttaaaaggggagacgaaatatgaa g" /listShort="S510, fadG, ykzU, ykuH, S511, ykuI, S512" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(1391362) /Source="Nicolas_upshifts" /id="D786" /incds=0 /nref=3 /ntot=49 /MaxReadThrough="1.82681" /MaxDrop="3.39884" /score="-0.170855674" /energy="-4.8" /TU="NA" /idTUdmin="U1157" /TUdmin="-2542" /isTUend="FALSE" /label="downshifts" CDS 1391465..1393195 /gene="ykuG" /locus_tag="BSU_14071" /old_locus_tag="BSU14071" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17189250; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative cell wall-binding protein" /protein_id="YP_003097723.1" /db_xref="EnsemblGenomes-Gn:BSU14071" /db_xref="EnsemblGenomes-Tr:CAX52614" /db_xref="InterPro:IPR002477" /db_xref="InterPro:IPR015020" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR036365" /db_xref="InterPro:IPR036366" /db_xref="UniProtKB/Swiss-Prot:O34320" /translation="MDEMVLLTQEWLNETYKGKSGYNSIEENGKTGWKTMYALTRALQ LELGITQTSDSFGPTTLRKLKELGPISTSTNSKKNIVKIIQGALYCKGYGPGGLTGTF GQGTKEAIAEMQLHMGLSKTDGVVTPKVFKALLNMDSYILLNGASEKVRSIQQWLNNK YYNRENFYFMPCDGLYSRDTQKSLVYAIQYEEGLSDSIANGNFGPTTQRLIPVLRIGE TDEKNSFIHLFQAALIFNGYNVPFDGVYSESVRSKVKAFQSFAKLQQSGTADFQTWAS LLVSTGDPNRKGVACDSITQITSDRAESLKRAGYKIVGRYLTNAPGSTLNKKIQPGEL ETILKSGLNVFPIYQTYGGATNYFNKEQGKKDAFAAYKAAKEYGFKNNTVIYFAVDYD AYGNDLNNNIIPHFEGINEIMNGFLGSTYKIGIYAPRNVCTIVSKKGLAFASFVSGMS TGFSGNLGYPLPYNWAFDQISTITVGNGSGMIEIDNDICSGLDNGVNTINIVPSENKK FFDQIDVLYETAEKYAQMQSDLNNGVKKTQLANELVAQYLRKDDYKGWKWVPTAGQID PIYREWAVKR*" /label="ykuG CDS" gene 1391465..1393195 /gene="ykuG" /locus_tag="BSU_14071" /old_locus_tag="BSU14071" /label="ykuG gene" CDS 1393261..1393779 /gene="ykzU" /locus_tag="BSU_14072" /old_locus_tag="BSU14072" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097724.1" /db_xref="EnsemblGenomes-Gn:BSU14072" /db_xref="EnsemblGenomes-Tr:CAX52615" /db_xref="UniProtKB/Swiss-Prot:C0H408" /translation="MATYNAIIYSGGYSQTLRDFAGWTGDLLTTIQDMKLHAQEFNSP YDAAMKIIGNMYQFSLDDLFSDVDAINLANKTSVGANAQPLNIAIRDYYSNNDCMNRF TQFVNNRFDGSLDKIFSEAEYYLNTNLDPVVVPIRLAFKRAFDVEDYSEEIGKITAQA FRDVIEKKMISE*" /label="ykzU CDS" gene 1393261..1393779 /gene="ykzU" /locus_tag="BSU_14072" /old_locus_tag="BSU14072" /label="ykzU gene" downshifts 1393777 /Source="Nicolas_upshifts" /id="D787" /incds=0 /nref=1 /ntot=11 /MaxReadThrough="5.57306" /MaxDrop="3.8585" /score="8.20824413" /energy="-13" /TU="U1158,U1159" /idTUdmin="U1158" /TUdmin="-682" /isTUend="FALSE" /label="downshifts" promotor_-35 1393822..1393827 /Source="Nicolas_upshift_promotors" /id="U1160" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2279 /SigmaFactorBS="gcaaaacaagcgaacgttaaaactggtcgttcgcttgttTTA TTTtctatttaaattTATGATATAATTTTTAAAGAttaaggagtgattcattgaagaa a" /listShort="ykuH, S511, ykuI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1393840..1393859 /Source="Nicolas_upshift_promotors" /id="U1160" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2279 /SigmaFactorBS="gcaaaacaagcgaacgttaaaactggtcgttcgcttgttTTA TTTtctatttaaattTATGATATAATTTTTAAAGAttaaggagtgattcattgaagaa a" /listShort="ykuH, S511, ykuI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1393843 /Source="Nicolas_upshifts" /id="U1160" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2279 /SigmaFactorBS="gcaaaacaagcgaacgttaaaactggtcgttcgcttgttTTA TTTtctatttaaattTATGATATAATTTTTAAAGAttaaggagtgattcattgaagaa a" /listShort="ykuH, S511, ykuI" /GFF_Attribute="listLong" /label="upshifts" CDS 1393875..1394423 /gene="ykuH" /locus_tag="BSU_14080" /old_locus_tag="BSU14080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389291.1" /db_xref="EnsemblGenomes-Gn:BSU14080" /db_xref="EnsemblGenomes-Tr:CAB13281" /db_xref="GOA:O31696" /db_xref="SubtiList:BG13292" /db_xref="UniProtKB/Swiss-Prot:O31696" /translation="MKKLLKKLVVLFLSSLVIIFNVWYFIICAFSPEYYQNTNLTSNE IIRFEKLYHIDFPDETKFIKAREYLAGPGGDTSAVLYVSLPTKRVEKVLSDYTYMKIN YTDNVGSMYGVDVSKSVAGLTTLTFGTYDKKGTFYNMKHDDDWMYKGTDWNLYFWTAA SYNAVIFVFVLVIVKQMNKILN*" /label="ykuH CDS" gene 1393875..1394423 /gene="ykuH" /locus_tag="BSU_14080" /old_locus_tag="BSU14080" /label="ykuH gene" S_feature 1394424..1394575 /Source="Nicolas_S_feature" /locus_tag="new_1482096_1482247" /HighExp="HiOs, LPhT, Salt, T0.0H, HiTm, T-0.40H, Fru, T-1.10H, LPh, T-4.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0" /TUlongSig="SigA" /TUlongPSig="0.97" /label="S511" CDS 1394576..1395799 /gene="ykuI" /locus_tag="BSU_14090" /old_locus_tag="BSU14090" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19244251, 28536559; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="putative cyclic-di-GMP receptor (no phosphodiesterase activity)" /protein_id="NP_389292.1" /db_xref="EnsemblGenomes-Gn:BSU14090" /db_xref="EnsemblGenomes-Tr:CAB13282" /db_xref="InterPro:IPR001633" /db_xref="InterPro:IPR018842" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR035919" /db_xref="PDB:2BAS" /db_xref="PDB:2W27" /db_xref="SubtiList:BG13293" /db_xref="UniProtKB/Swiss-Prot:O35014" /translation="MLDPLDILTNIDDVLPYYQAIFSAEEQKVVGYEVLGRILADSEI QSLGPFFLDAGIPEEYKLEVDNRIIRQALDRFLEADSDLLIFMNQDANLLMLDHGESF LELLKEYEAKGIELHRFVLEITEHNFEGDIEQLYHMLAYYRTYGIKIAVDNIGKESSN LDRIALLSPDLLKIDLQALKVSQPSPSYEHVLYSISLLARKIGAALLYEDIEANFQLQ YAWRNGGRYFQGYYLVSPSETFLERDVLKQRLKTEFHQFITHEKKKLETVYEHSEQFY KRVHQAVTSLRKNNLSSDDDFIKKLAEELTDCSFRIYMCDEEGDQLTGNVFKQDGEWI YQPEYAEKNWSWRPYFLENIMRMRNLRKGFFSDLYSDLETGEMIRTFSYPMDDQMYLF IDLPYSYLYEQDGLI*" /label="ykuI CDS" gene 1394576..1395799 /gene="ykuI" /locus_tag="BSU_14090" /old_locus_tag="BSU14090" /label="ykuI gene" promotor_-10 complement(1395762..1395780) /Source="Nicolas_upshift_promotors" /id="U1161" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1186 /SigmaFactorBS="tttcatttcataaaaaaaacggcctttcagccGTTAAAtcag tccgtcctgcTCATATAAATAAGAATAAGgcaagtctataaataaatacatctgatca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1395772) /Source="Nicolas_upshifts" /id="U1161" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1186 /SigmaFactorBS="tttcatttcataaaaaaaacggcctttcagccGTTAAAtcag tccgtcctgcTCATATAAATAAGAATAAGgcaagtctataaataaatacatctgatca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1395778 /Source="Nicolas_upshifts" /id="D788" /incds=0 /nref=132 /ntot=229 /MaxReadThrough="3.48305" /MaxDrop="4.61382" /score="32.6727777" /energy="-7.5" /TU="U1159" /idTUdmin="U1160" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 complement(1395795..1395800) /Source="Nicolas_upshift_promotors" /id="U1161" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1186 /SigmaFactorBS="tttcatttcataaaaaaaacggcctttcagccGTTAAAtcag tccgtcctgcTCATATAAATAAGAATAAGgcaagtctataaataaatacatctgatca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1395848..1395855 /Source="Nicolas_upshift_promotors" /id="U1162" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2096 /SigmaFactorBS="aaggccgttttttttatgaaatgaaaaaaatatcaaaaaacG ATTGACAttgatactgagaatCATTATCATTTAATTATAGAgagaagctactctctgt t" /listShort="S512, S513, S514, ykuJ, S515, ykuK, ykzF" /listLong="S516, ykuL, S517, ccpC" /label="promotor_-35" S_feature 1395867..1395968 /Source="Nicolas_S_feature" /locus_tag="new_1483539_1483640" /HighExp="B36, B60, nit, Pyr, BI, HiOs, T-0.40H, S5, GM 15, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0" /TUlongSig="NA" /TUlongPSig="NA" /label="S512" upshifts 1395867 /Source="Nicolas_upshifts" /id="U1162" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2096 /SigmaFactorBS="aaggccgttttttttatgaaatgaaaaaaatatcaaaaaacG ATTGACAttgatactgagaatCATTATCATTTAATTATAGAgagaagctactctctgt t" /listShort="S512, S513, S514, ykuJ, S515, ykuK, ykzF" /listLong="S516, ykuL, S517, ccpC" /label="upshifts" promotor_-10 1395870..1395889 /Source="Nicolas_upshift_promotors" /id="U1162" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2096 /SigmaFactorBS="aaggccgttttttttatgaaatgaaaaaaatatcaaaaaacG ATTGACAttgatactgagaatCATTATCATTTAATTATAGAgagaagctactctctgt t" /listShort="S512, S513, S514, ykuJ, S515, ykuK, ykzF" /listLong="S516, ykuL, S517, ccpC" /label="promotor_-10" misc_RNA 1395885..1395968 /gene="fsrA" /locus_tag="BSU_misc_RNA_69" /product="regulatory RNA controlling iron-dependent metabolism" /experiment="publication(s) with functional evidences, PMID:18697947, 22389480, 22427629, 24576839" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18697947, 22389480, 22427629, 24576839; Product type n: RNA" /function="12: Regulatory functions" /label="fsrA RNA" gene 1395885..1395968 /gene="fsrA" /locus_tag="BSU_misc_RNA_69" /label="fsrA gene" downshifts 1395925 /Source="Nicolas_upshifts" /id="D789" /incds=0 /nref=61 /ntot=192 /MaxReadThrough="6.41968" /MaxDrop="7.54463" /score="16.5898261" /energy="-8.8" /TU="U1159,U1162" /idTUdmin="U1159" /TUdmin="-74" /isTUend="FALSE" /label="downshifts" promotor_-35 1395979..1395984 /Source="Nicolas_upshift_promotors" /id="U1163" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1032 /SigmaFactorBS="aaaacttggcgctacccccgccaagttttttatttgtcaaAG CATAggacaatccaatgaaaCAATAAACCTAACTAGTGGtaaacgtttaacacgggga g" /listShort="S513, S514, ykuJ, S515, ykuK" /listLong="ykzF, S516, ykuL, S517, ccpC" /label="promotor_-35" S_feature 1395999..1396283 /Source="Nicolas_S_feature" /locus_tag="new_1483671_1483955" /HighExp="S4, H2O2, S5, Paraq, B60, nit, GM 10, B36, GM 25, GM 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.147452" /TUshortSig="SigEF, SigA" /TUshortPSig="0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S513" upshifts 1395999 /Source="Nicolas_upshifts" /id="U1163" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1032 /SigmaFactorBS="aaaacttggcgctacccccgccaagttttttatttgtcaaAG CATAggacaatccaatgaaaCAATAAACCTAACTAGTGGtaaacgtttaacacgggga g" /listShort="S513, S514, ykuJ, S515, ykuK" /listLong="ykzF, S516, ykuL, S517, ccpC" /label="upshifts" promotor_-10 1396001..1396019 /Source="Nicolas_upshift_promotors" /id="U1163" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1032 /SigmaFactorBS="aaaacttggcgctacccccgccaagttttttatttgtcaaAG CATAggacaatccaatgaaaCAATAAACCTAACTAGTGGtaaacgtttaacacgggga g" /listShort="S513, S514, ykuJ, S515, ykuK" /listLong="ykzF, S516, ykuL, S517, ccpC" /label="promotor_-10" promotor_-35 1396260..1396266 /Source="Nicolas_upshift_promotors" /id="U1164" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=786 /SigmaFactorBS="atgctgccaaagattcgaaaaaaattataattatgTGCATGA cattcaaaaaaagCCTCAAACTAAAgaaaaatagtttttttcactttttttctttgct t" /listShort="S514, ykuJ, S515, ykuK, ykzF" /listLong="S516, ykuL, S517, ccpC" /label="promotor_-35" promotor_-10 1396280..1396291 /Source="Nicolas_upshift_promotors" /id="U1164" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=786 /SigmaFactorBS="atgctgccaaagattcgaaaaaaattataattatgTGCATGA cattcaaaaaaagCCTCAAACTAAAgaaaaatagtttttttcactttttttctttgct t" /listShort="S514, ykuJ, S515, ykuK, ykzF" /listLong="S516, ykuL, S517, ccpC" /label="promotor_-10" S_feature 1396285..1396372 /Source="Nicolas_S_feature" /locus_tag="new_1483957_1484044" /HighExp="S5, S4, H2O2, B60, Paraq, nit, B36, GM 10, S7, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigEF, SigA" /TUshortPSig="0.999, 0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S514" upshifts 1396285 /Source="Nicolas_upshifts" /id="U1164" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=786 /SigmaFactorBS="atgctgccaaagattcgaaaaaaattataattatgTGCATGA cattcaaaaaaagCCTCAAACTAAAgaaaaatagtttttttcactttttttctttgct t" /listShort="S514, ykuJ, S515, ykuK, ykzF" /listLong="S516, ykuL, S517, ccpC" /label="upshifts" misc_feature 1396361..1396380 /Source="Nicolas_upshift_promotors" /id="U1165" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.48951048951049" /psig=1 /xcortree=2552 /SigmaFactorBS="ttttctttgcttaaattcagcagtgaaaatgccatcctgtcc gacttTATGGTATGATGCTCAATAGaacttgtattataataaatacttgttgatttga a" /listShort="ykuJ, S515, ykuK, ykzF, S516, ykuL, S517, ccpC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1396374 /Source="Nicolas_upshifts" /id="U1165" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.48951048951049" /psig=1 /xcortree=2552 /SigmaFactorBS="ttttctttgcttaaattcagcagtgaaaatgccatcctgtcc gacttTATGGTATGATGCTCAATAGaacttgtattataataaatacttgttgatttga a" /listShort="ykuJ, S515, ykuK, ykzF, S516, ykuL, S517, ccpC" /GFF_Attribute="listLong" /label="upshifts" CDS 1396445..1396684 /gene="ykuJ" /locus_tag="BSU_14100" /old_locus_tag="BSU14100" /function="10.3: tRNA and rRNA base modification" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16387657, 18436958; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA-specific modification enzyme subunit" /protein_id="NP_389293.1" /db_xref="EnsemblGenomes-Gn:BSU14100" /db_xref="EnsemblGenomes-Tr:CAB13283" /db_xref="InterPro:IPR014904" /db_xref="PDB:2FFG" /db_xref="SubtiList:BG13294" /db_xref="UniProtKB/Swiss-Prot:O34588" /translation="MSQLMGIITRLQSLQETAEAANEPMQRYFEVNGEKICSVKYFEK NQTFELTVFQKGEKPNTYPFDNIDMVSIEIFELLQ*" /label="ykuJ CDS" gene 1396445..1396684 /gene="ykuJ" /locus_tag="BSU_14100" /old_locus_tag="BSU14100" /label="ykuJ gene" S_feature 1396685..1396793 /Source="Nicolas_S_feature" /locus_tag="new_1484357_1484465" /HighExp="H2O2, LoTm, G135, Paraq, G180, LBGexp, G150, Oxctl, dia0, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF, SigEF, SigA" /TUshortPSig="1, 0.999, 0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S515" CDS 1396794..1397312 /gene="ykuK" /locus_tag="BSU_14110" /old_locus_tag="BSU14110" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16165328, 24464998; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA-binding enzyme component" /protein_id="NP_389294.1" /db_xref="EnsemblGenomes-Gn:BSU14110" /db_xref="EnsemblGenomes-Tr:CAB13284" /db_xref="InterPro:IPR007405" /db_xref="SubtiList:BG13295" /db_xref="UniProtKB/Swiss-Prot:O34776" /translation="MADSFLFYNLSEAQMTFQDVMERLKAFVQKDPRSSYVLSIGTDS QVYRDYTKFITALHLHRTGKGAWGCLKNHTVDRPIHSLREKISLETAYSQETAAHILD GHLMDITDLLLPFTGEGADLTFEVHLDIGKKGLTKDLIQEMTGRITSMGIEAKIKPDS YTAFSYANRFTK*" /label="ykuK CDS" gene 1396794..1397312 /gene="ykuK" /locus_tag="BSU_14110" /old_locus_tag="BSU14110" /label="ykuK gene" promotor_-35 1397349..1397356 /Source="Nicolas_upshift_promotors" /id="U1166" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.946053946053946" /psig=1 /xcortree=454 /SigmaFactorBS="aagccaaggtaaatgtcgaattatgCGGTTGACgtttgttat ctgaTTACTTATTCTAGCGGTAGAgctgaaagtaagttgtcttgctttcagaggtatt c" /listShort="ykzF, S516, ykuL, S517, ccpC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1397370..1397389 /Source="Nicolas_upshift_promotors" /id="U1166" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.946053946053946" /psig=1 /xcortree=454 /SigmaFactorBS="aagccaaggtaaatgtcgaattatgCGGTTGACgtttgttat ctgaTTACTTATTCTAGCGGTAGAgctgaaagtaagttgtcttgctttcagaggtatt c" /listShort="ykzF, S516, ykuL, S517, ccpC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1397384 /Source="Nicolas_upshifts" /id="U1166" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.946053946053946" /psig=1 /xcortree=454 /SigmaFactorBS="aagccaaggtaaatgtcgaattatgCGGTTGACgtttgttat ctgaTTACTTATTCTAGCGGTAGAgctgaaagtaagttgtcttgctttcagaggtatt c" /listShort="ykzF, S516, ykuL, S517, ccpC" /GFF_Attribute="listLong" /label="upshifts" CDS 1397446..1397643 /gene="abbA" /locus_tag="BSU_14120" /old_locus_tag="BSU14120" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18840696, 24534728" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18840696, 24534728; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of AbrB repressor" /protein_id="NP_389295.1" /db_xref="EnsemblGenomes-Gn:BSU14120" /db_xref="EnsemblGenomes-Tr:CAB13285" /db_xref="GOA:O31697" /db_xref="InterPro:IPR025446" /db_xref="PDB:2LZF" /db_xref="SubtiList:BG13334" /db_xref="UniProtKB/Swiss-Prot:O31697" /translation="MRMSLIGERFTEEEQKLLLNILINHEYAIELLSSEINDIETGTK NVDGTTYKKLVTLYDRFRFEN*" /label="abbA CDS" gene 1397446..1397643 /gene="abbA" /locus_tag="BSU_14120" /old_locus_tag="BSU14120" /label="abbA gene" downshifts 1397639 /Source="Nicolas_upshifts" /id="D790" /incds=0 /nref=114 /ntot=265 /MaxReadThrough="5.72556" /MaxDrop="4.65809" /score="2.45376472" /energy="-6.8" /TU="U1165,U1166" /idTUdmin="U1162" /TUdmin=12 /isTUend="TRUE" /label="downshifts" S_feature 1397684..1397780 /Source="Nicolas_S_feature" /locus_tag="new_1485356_1485452" /HighExp="M9-stat, T3.30H, T3.0H, T4.0H, M0t90, T1.0H, T5.0H, T2.30H, T1.30H, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.23094000000000001" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="SigGF, SigEF, SigA" /TUlongPSig="0.999, 0.997, 1" /label="S516" CDS 1397781..1398224 /gene="ykuL" /locus_tag="BSU_14130" /old_locus_tag="BSU14130" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11985717; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative RNA-binding protein" /protein_id="NP_389296.1" /db_xref="EnsemblGenomes-Gn:BSU14130" /db_xref="EnsemblGenomes-Tr:CAB13286" /db_xref="PDB:1YAV" /db_xref="SubtiList:BG13296" /db_xref="UniProtKB/Swiss-Prot:O31698" /translation="MISLQSDQLLEATVGQFMIEADKVAHVQVGNNLEHALLVLTKTG YTAIPVLDPSYRLHGLIGTNMIMNSIFGLERIEFEKLDQITVEEVMLTDIPRLHINDP IMKGFGMVINNGFVCVENDEQVFEGIFTRRVVLKELNKHIRSLNK*" /label="ykuL CDS" gene 1397781..1398224 /gene="ykuL" /locus_tag="BSU_14130" /old_locus_tag="BSU14130" /label="ykuL gene" S_feature 1398225..1398332 /Source="Nicolas_S_feature" /locus_tag="new_1485897_1486004" /HighExp="M0t90, M40t90, M9-stat, T1.0H, T3.30H, T3.0H, T4.0H, S2, T1.30H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="SigGF, SigEF, SigA" /TUlongPSig="0.999, 0.997, 1" /label="S517" promotor_-35 1398300..1398305 /Source="Nicolas_upshift_promotors" /id="U1167" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.473526473526474" /psig="0.998001998001998" /xcortree=3032 /SigmaFactorBS="catacataatttaaacgagaatagggCTTGAAtaagaaacta agatTTTATTAGAATGGGAGATAAgaaaaacttattgataacaaaaaggaggacgaca t" /listShort="ccpC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1398320..1398339 /Source="Nicolas_upshift_promotors" /id="U1167" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.473526473526474" /psig="0.998001998001998" /xcortree=3032 /SigmaFactorBS="catacataatttaaacgagaatagggCTTGAAtaagaaacta agatTTTATTAGAATGGGAGATAAgaaaaacttattgataacaaaaaggaggacgaca t" /listShort="ccpC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1398334 /Source="Nicolas_upshifts" /id="U1167" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.473526473526474" /psig="0.998001998001998" /xcortree=3032 /SigmaFactorBS="catacataatttaaacgagaatagggCTTGAAtaagaaacta agatTTTATTAGAATGGGAGATAAgaaaaacttattgataacaaaaaggaggacgaca t" /listShort="ccpC" /GFF_Attribute="listLong" /label="upshifts" CDS 1398373..1399254 /gene="ccpC" /locus_tag="BSU_14140" /old_locus_tag="BSU14140" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14636591, 16352834, 16395550, 23139400" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14636591, 16352834, 16395550, 23139400; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of citB and citZ" /protein_id="NP_389297.1" /db_xref="EnsemblGenomes-Gn:BSU14140" /db_xref="EnsemblGenomes-Tr:CAB13287" /db_xref="GOA:O34827" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13297" /db_xref="UniProtKB/Swiss-Prot:O34827" /translation="MQLQELHMLVVLAEELNMRKAAERLFVSQPALSQRLQTIEKAWG TKIFLRSQKGLTVTPAGEKIIQFANDVTLEQERIRENIDELEGEIHGTLKLAVASIIG QHWLPKVLKTYVEKYPNAKISLITGWSSEMLKSLYEDQVHIGIIRGNPEWKGRKDYLM TDHLYLVDTEISCIEDIAHTERPFIQFKSDSTYFQEIQHWWHQKFKTSPKQTILVDQI ETCKQMALHGIGYAILPSVTLQNEDKVNKMPLLDMKGHPIGRDTWLLGYEPAFELKQV QAFVQVIKDMLDQENPF*" /label="ccpC CDS" gene 1398373..1399254 /gene="ccpC" /locus_tag="BSU_14140" /old_locus_tag="BSU14140" /label="ccpC gene" downshifts 1399233 /Source="Nicolas_upshifts" /id="D791" /incds=0 /nref=168 /ntot=242 /MaxReadThrough="1.76921" /MaxDrop="5.2505" /score="37.6563581" /energy="-8.3" /TU="NA" /idTUdmin="U1165" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1399289..1399296 /Source="Nicolas_upshift_promotors" /id="U1168" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.614385614385614" /psig=1 /xcortree=2113 /SigmaFactorBS="gacagcgaggtgctgtcttttttttatttatctGTTGACAAt gaaaatcattatcATTTAAAGTGATACATATGAtattgaaaatcattatcaactaatg g" /listShort="ykuN, ykuO, ykuP, dapH, dapL, ykuS" /listLong="S518, S519, ykuU, ykuV" /label="promotor_-35" promotor_-10 1399311..1399330 /Source="Nicolas_upshift_promotors" /id="U1168" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.614385614385614" /psig=1 /xcortree=2113 /SigmaFactorBS="gacagcgaggtgctgtcttttttttatttatctGTTGACAAt gaaaatcattatcATTTAAAGTGATACATATGAtattgaaaatcattatcaactaatg g" /listShort="ykuN, ykuO, ykuP, dapH, dapL, ykuS" /listLong="S518, S519, ykuU, ykuV" /label="promotor_-10" upshifts 1399316 /Source="Nicolas_upshifts" /id="U1168" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.614385614385614" /psig=1 /xcortree=2113 /SigmaFactorBS="gacagcgaggtgctgtcttttttttatttatctGTTGACAAt gaaaatcattatcATTTAAAGTGATACATATGAtattgaaaatcattatcaactaatg g" /listShort="ykuN, ykuO, ykuP, dapH, dapL, ykuS" /listLong="S518, S519, ykuU, ykuV" /label="upshifts" CDS 1399366..1399842 /gene="fldN" /locus_tag="BSU_14150" /old_locus_tag="BSU14150" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12354229, 15449930, 17127770, 20186410, 21665975, 24214949" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15449930, 17127770, 20186410, 21665975, 24214949; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="short-chain flavodoxin (acts in lipid desaturation)" /protein_id="NP_389298.1" /db_xref="EnsemblGenomes-Gn:BSU14150" /db_xref="EnsemblGenomes-Tr:CAB13288" /db_xref="GOA:O34737" /db_xref="InterPro:IPR001094" /db_xref="InterPro:IPR008254" /db_xref="InterPro:IPR010087" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG13298" /db_xref="UniProtKB/Swiss-Prot:O34737" /translation="MAKALITYASMSGNTEDIAFIIKDTLQEYELDIDCVEINDMDAS CLTSYDYVLIGTYTWGDGDLPYEAEDFFEEVKQIQLNGLKTACFGSGDYSYPKFCEAV NLFNVMLQEAGAAVYQETLKIELAPETDEDVESCRAFARGFLAWADYMNKEKIHVS*" /label="fldN CDS" gene 1399366..1399842 /gene="fldN" /locus_tag="BSU_14150" /old_locus_tag="BSU14150" /label="fldN gene" CDS 1399832..1400725 /gene="ykuO" /locus_tag="BSU_14160" /old_locus_tag="BSU14160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12354229, 24214949" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389299.1" /db_xref="EnsemblGenomes-Gn:BSU14160" /db_xref="EnsemblGenomes-Tr:CAB13289" /db_xref="InterPro:IPR015943" /db_xref="SubtiList:BG13299" /db_xref="UniProtKB/Swiss-Prot:O34879" /translation="MFHKGATAVTASAFSGYFVAVQREGIFHYSLEQGWRKLFRLKSK IHCISYIGPYLFGVGEKGTVIRSADEGKTWTMSSFPTNATVWAITGRNNGFVCAHGKH CIYVSDDFGVSWRVAKPFAEFHNPPVIRSLCLHGGNLFIGTQIHEYFGGIWAYDIKRD TVQVVKKEKNRMTASMLVFNENWLVAAMGSVKGKHGAVTVRNLLNGEEFTIQSSMIRN EESFLDLSEDDGIIYVTTTQDENGFSRIYQVDLEARSLKWFDTIKGHGWRVANQKENF FCAGLYECKFVQPYEVSAMIH*" /label="ykuO CDS" gene 1399832..1400725 /gene="ykuO" /locus_tag="BSU_14160" /old_locus_tag="BSU14160" /label="ykuO gene" CDS 1400741..1401196 /gene="fldP" /locus_tag="BSU_14170" /old_locus_tag="BSU14170" /experiment="publication(s) with functional evidences, PMID:12354229, 15449930, 17127770, 20186410, 21665975, 24214949" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15449930, 17127770, 20186410, 21665975, 24214949; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="short-chain flavodoxin" /protein_id="NP_389300.2" /db_xref="EnsemblGenomes-Gn:BSU14170" /db_xref="EnsemblGenomes-Tr:CAB13290" /db_xref="GOA:O34589" /db_xref="InterPro:IPR001094" /db_xref="InterPro:IPR001226" /db_xref="InterPro:IPR008254" /db_xref="InterPro:IPR010087" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG13300" /db_xref="UniProtKB/Swiss-Prot:O34589" /translation="MAKILLVYATMSGNTEAMADLIEKGLQEALAEVDRFEAMDIDDA QLFTDYDHVIMGTYTWGDGDLPDEFLDLVEDMEEIDFSGKTCAVFGSGDTAYEFFCGA VDTLEAKIKERGGDIVLPSVKIENNPEGEEEEELINFGRQFAKKSGCAV*" /label="fldP CDS" gene 1400741..1401196 /gene="fldP" /locus_tag="BSU_14170" /old_locus_tag="BSU14170" /label="fldP gene" promotor_-10 complement(1401012..1401031) /Source="Nicolas_upshift_promotors" /id="U1169" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.88011988011988" /psig="0.88011988011988" /xcortree=766 /SigmaFactorBS="tccaccgcgttcttttatttttgcctctagcgTATCAACCGc tccgcagaaaaaTTCATATGCTGTATCACCGGaaccgaatacagcgcatgttttgccg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1401025) /Source="Nicolas_upshifts" /id="U1169" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.88011988011988" /psig="0.88011988011988" /xcortree=766 /SigmaFactorBS="tccaccgcgttcttttatttttgcctctagcgTATCAACCGc tccgcagaaaaaTTCATATGCTGTATCACCGGaaccgaatacagcgcatgttttgccg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1401045..1401053) /Source="Nicolas_upshift_promotors" /id="U1169" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.88011988011988" /psig="0.88011988011988" /xcortree=766 /SigmaFactorBS="tccaccgcgttcttttatttttgcctctagcgTATCAACCGc tccgcagaaaaaTTCATATGCTGTATCACCGGaaccgaatacagcgcatgttttgccg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1401190 /Source="Nicolas_upshifts" /id="D792" /incds=0 /nref=2 /ntot=54 /MaxReadThrough="6.48855" /MaxDrop="3.75748" /score="20.7202933" /energy="-9" /TU="U1168" /idTUdmin="U1165" /TUdmin=1957 /isTUend="FALSE" /label="downshifts" promotor_-35 1401235..1401242 /Source="Nicolas_upshift_promotors" /id="U1170" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.49050949050949" /psig=1 /xcortree=2341 /SigmaFactorBS="tcactcactgggaactgctaaaacggctgttcctttttTTCT TGTCtttgtatctttccTTTGATACAGTAATGAGGTAgaaaatcaggaggaggactat a" /listShort="dapH, dapL, ykuS" /listLong="S518, S519, ykuU, ykuV" /label="promotor_-35" promotor_-10 1401256..1401275 /Source="Nicolas_upshift_promotors" /id="U1170" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.49050949050949" /psig=1 /xcortree=2341 /SigmaFactorBS="tcactcactgggaactgctaaaacggctgttcctttttTTCT TGTCtttgtatctttccTTTGATACAGTAATGAGGTAgaaaatcaggaggaggactat a" /listShort="dapH, dapL, ykuS" /listLong="S518, S519, ykuU, ykuV" /label="promotor_-10" upshifts 1401257 /Source="Nicolas_upshifts" /id="U1170" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.49050949050949" /psig=1 /xcortree=2341 /SigmaFactorBS="tcactcactgggaactgctaaaacggctgttcctttttTTCT TGTCtttgtatctttccTTTGATACAGTAATGAGGTAgaaaatcaggaggaggactat a" /listShort="dapH, dapL, ykuS" /listLong="S518, S519, ykuU, ykuV" /label="upshifts" CDS 1401301..1402011 /gene="dapH" /locus_tag="BSU_14180" /old_locus_tag="BSU14180" /EC_number="2.3.1.89" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:5411754, 10368155, 11910040, 12682299, 14627808" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 5411754, 10368155, 11910040, 12682299, 14627808; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tetrahydrodipicolinate N-acetyltransferase" /protein_id="NP_389301.2" /db_xref="EnsemblGenomes-Gn:BSU14180" /db_xref="EnsemblGenomes-Tr:CAB13291" /db_xref="GOA:O34981" /db_xref="InterPro:IPR001451" /db_xref="InterPro:IPR011004" /db_xref="InterPro:IPR013710" /db_xref="InterPro:IPR016036" /db_xref="InterPro:IPR018357" /db_xref="InterPro:IPR019873" /db_xref="SubtiList:BG13301" /db_xref="UniProtKB/Swiss-Prot:O34981" /translation="MKMMDANEIISFIQNSTKSTPVKVYVKGELEGINFGESAKAFIN GNTGVVFGEWSEIQTAIEENQSKIEDYVVENDRRNSAIPMLDLKNIKARIEPGAIIRD QVEIGDNAVIMMGASINIGSVIGEGTMIDMNVVLGGRATVGKNCHIGAGSVLAGVIEP PSAKPVVIEDDVVIGANAVVLEGVTVGKGAVVAAGAIVVNDVEPYTVVAGTPAKKIKD IDEKTKGKTEIKQELRQL*" /label="dapH CDS" gene 1401301..1402011 /gene="dapH" /locus_tag="BSU_14180" /old_locus_tag="BSU14180" /label="dapH gene" downshifts complement(1401310) /Source="Nicolas_upshifts" /id="D793" /incds=0 /nref=60 /ntot=165 /MaxReadThrough="1.03272" /MaxDrop="4.75802" /score="28.9046709" /energy="-15" /TU="NA" /idTUdmin="U1171" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1401420..1401424) /Source="Nicolas_upshift_promotors" /id="U1171" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.005994005994006" /xcortree=40 /SigmaFactorBS="tgctgtttggatttcgctccattcaccgaaaacgacacCagt gtttccattgataaAAGCTttcgcagattcaccgaaattgattccttccagctcacct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1401420) /Source="Nicolas_upshifts" /id="U1171" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.005994005994006" /xcortree=40 /SigmaFactorBS="tgctgtttggatttcgctccattcaccgaaaacgacacCagt gtttccattgataaAAGCTttcgcagattcaccgaaattgattccttccagctcacct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1402081..1403205 /gene="dapI" /locus_tag="BSU_14190" /old_locus_tag="BSU14190" /EC_number="3.5.1.47" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14627808, 17093042, 24261876" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14627808, 17093042, 24261876; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetyl-diaminopimelate deacetylase" /protein_id="NP_389302.1" /db_xref="EnsemblGenomes-Gn:BSU14190" /db_xref="EnsemblGenomes-Tr:CAB13292" /db_xref="GOA:O34916" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR017439" /db_xref="InterPro:IPR023905" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG13302" /db_xref="UniProtKB/Swiss-Prot:O34916" /translation="MKIEELIAIRRDLHRIPELGFQEFKTQQYLLNVLEQYPQDRIEI EKWRTGLFVKVNGTAPEKMLAYRADIDALSIEEQTGLPFASEHHGNMHACGHDLHMTI ALGIIDHFVHHPVKHDLLFLFQPAEEGPGGAEPMLESDVLKKWQPDFITALHIAPELP VGTIATKSGLLFANTSELVIDLEGKGGHAAYPHLAEDMVVAASTLVTQLQTIISRNTD PLDSAVITVGTITGGSAQNIIAETAHLEGTIRTLSEESMKQVKERIEDVVKGIEIGFR CKGKVTYPSVYHQVYNTSGLTEEFMSFVAEHQLATVIEAKEAMTGEDFGYMLKKYPGF MFWLGADSEHGLHHAKLNPDENAIETAVHVMTGYFSVYAN*" /label="dapI CDS" gene 1402081..1403205 /gene="dapI" /locus_tag="BSU_14190" /old_locus_tag="BSU14190" /label="dapI gene" promotor_-35 1403217..1403223 /Source="Nicolas_upshift_promotors" /id="U1172" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=883 /SigmaFactorBS="ggttatttttctgtttatgccaattaagtacaaatgaaAGAA TAAaattccataaaatGAGCACTCTAGTaaacggaggtgttcaaaaatggctaaaaaa a" /listShort="ykuS, S518, S519, ykuU, ykuV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1403237..1403248 /Source="Nicolas_upshift_promotors" /id="U1172" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=883 /SigmaFactorBS="ggttatttttctgtttatgccaattaagtacaaatgaaAGAA TAAaattccataaaatGAGCACTCTAGTaaacggaggtgttcaaaaatggctaaaaaa a" /listShort="ykuS, S518, S519, ykuU, ykuV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1403239 /Source="Nicolas_upshifts" /id="U1172" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=883 /SigmaFactorBS="ggttatttttctgtttatgccaattaagtacaaatgaaAGAA TAAaattccataaaatGAGCACTCTAGTaaacggaggtgttcaaaaatggctaaaaaa a" /listShort="ykuS, S518, S519, ykuU, ykuV" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1403243..1403257) /Source="Nicolas_upshift_promotors" /id="U1173" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=701 /SigmaFactorBS="ttttcttttaaagcagcttctacatctgataacgattgttca attccaatttttttaGCCATttttgaacaCCTCCGTTTACTAGAgtgctcattttatg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1403267..1403271) /Source="Nicolas_upshift_promotors" /id="U1173" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=701 /SigmaFactorBS="ttttcttttaaagcagcttctacatctgataacgattgttca attccaatttttttaGCCATttttgaacaCCTCCGTTTACTAGAgtgctcattttatg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1403267..1403512 /gene="ykuS" /locus_tag="BSU_14200" /old_locus_tag="BSU14200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389303.1" /db_xref="EnsemblGenomes-Gn:BSU14200" /db_xref="EnsemblGenomes-Tr:CAB13293" /db_xref="InterPro:IPR005370" /db_xref="SubtiList:BG13303" /db_xref="UniProtKB/Swiss-Prot:O34783" /translation="MAKKIGIEQSLSDVEAALKEKGYDVVMMKSPADAQGCDCCVVTG LDNNVQGIADTVTQAPVITASGMTAEEICSEVESRIQ*" /label="ykuS CDS" gene 1403267..1403512 /gene="ykuS" /locus_tag="BSU_14200" /old_locus_tag="BSU14200" /label="ykuS gene" upshifts complement(1403268) /Source="Nicolas_upshifts" /id="U1173" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=701 /SigmaFactorBS="ttttcttttaaagcagcttctacatctgataacgattgttca attccaatttttttaGCCATttttgaacaCCTCCGTTTACTAGAgtgctcattttatg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1403500 /Source="Nicolas_upshifts" /id="D794" /incds=0 /nref=238 /ntot=269 /MaxReadThrough="3.49553" /MaxDrop="5.88829" /score="3.56597112" /energy="-9.9" /TU="U1172" /idTUdmin="U1168" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1403545..1404495 /Source="Nicolas_S_feature" /locus_tag="new_1491217_1492167" /HighExp="S4, S5, S6, S3, S7, S8, LoTm, BT, B36, G135" /AntisenseName="ykuT" /AntisenseCor="-0.479447808227356" /AntisenseRegPval="-16.100000000000001" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S518" CDS complement(1403549..1404352) /gene="mscT" /locus_tag="BSU_14210" /old_locus_tag="BSU14210" /function="16.6: Maintain" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12626684, 17665170, 18310427, 19252899, 21150093" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12626684, 17665170, 18310427, 19252899, 21150093; Product type t : transporter" /codon_start=1 /transl_table=11 /product="small-conductance mechanosensitive channel" /protein_id="NP_389304.2" /db_xref="EnsemblGenomes-Gn:BSU14210" /db_xref="EnsemblGenomes-Tr:CAB13294" /db_xref="GOA:O34897" /db_xref="InterPro:IPR006685" /db_xref="InterPro:IPR010920" /db_xref="InterPro:IPR011014" /db_xref="InterPro:IPR011066" /db_xref="SubtiList:BG13304" /db_xref="UniProtKB/Swiss-Prot:O34897" /translation="MDFIKQYDWAGLITNAGVLLIKLAIMILLYFIVRSLGMKIIKHL FAKFEEQNSLSIGRAHTLRSLTLNIFAYTLIFIFFVMVLDLFHYDPSALLAGAGIVGL AVGFGAQGLVSDIVTGFFILLEKQLDVGDYITVSTFDGIVEQVGLRTTQIRSFDGTLH YIPNRNITNVSNHSRGTMQALVDIKVPAERNIDEMIHILQQVCDETAAALPQIKEGPN VIGIQELGTSEIVIRVIAKTENMEQWRVERVLRKEIKNAFDRAFPKETE*" /label="mscT CDS" gene complement(1403549..1404352) /gene="mscT" /locus_tag="BSU_14210" /old_locus_tag="BSU14210" /label="mscT gene" downshifts complement(1403561) /Source="Nicolas_upshifts" /id="D795" /incds=0 /nref=16 /ntot=131 /MaxReadThrough="1.65551" /MaxDrop="4.4361" /score="29.0050313" /energy="-9.9" /TU="NA" /idTUdmin="U1174" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1404403..1404422) /Source="Nicolas_upshift_promotors" /id="U1174" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.892107892107892" /psig="0.975024975024975" /xcortree=2730 /SigmaFactorBS="caatttttaacaaatcatgtatgtctttgGCTTCGACatttt tgaataaaACGTTTAACATGGTCATGTAcagggtaactagtctcaatgtgcagcaatc a" /listShort="ykuT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1404412) /Source="Nicolas_upshifts" /id="U1174" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.892107892107892" /psig="0.975024975024975" /xcortree=2730 /SigmaFactorBS="caatttttaacaaatcatgtatgtctttgGCTTCGACatttt tgaataaaACGTTTAACATGGTCATGTAcagggtaactagtctcaatgtgcagcaatc a" /listShort="ykuT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1404436..1404443) /Source="Nicolas_upshift_promotors" /id="U1174" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.892107892107892" /psig="0.975024975024975" /xcortree=2730 /SigmaFactorBS="caatttttaacaaatcatgtatgtctttgGCTTCGACatttt tgaataaaACGTTTAACATGGTCATGTAcagggtaactagtctcaatgtgcagcaatc a" /listShort="ykuT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1404468..1404475 /Source="Nicolas_upshift_promotors" /id="U1175" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.849150849150849" /psig="0.999000999001" /xcortree=3170 /SigmaFactorBS="tcgaagccaaagacatacatgatttgttaaaAATTGACTcag gaaatctgcttTTATATAATGGCATTGCAATataactaaaaatggttaatcacccttt a" /listShort="S519, ykuU, ykuV" /listLong="rok" /label="promotor_-35" promotor_-10 1404490..1404509 /Source="Nicolas_upshift_promotors" /id="U1175" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.849150849150849" /psig="0.999000999001" /xcortree=3170 /SigmaFactorBS="tcgaagccaaagacatacatgatttgttaaaAATTGACTcag gaaatctgcttTTATATAATGGCATTGCAATataactaaaaatggttaatcacccttt a" /listShort="S519, ykuU, ykuV" /listLong="rok" /label="promotor_-10" S_feature 1404497..1404588 /Source="Nicolas_S_feature" /locus_tag="new_1492169_1492260" /HighExp="LPhT, Salt, Etha, M9-stat, M0t90, T4.0H, T5.0H, S4, Heat, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF" /TUshortPSig="0.999, 1" /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S519" upshifts 1404497 /Source="Nicolas_upshifts" /id="U1175" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.849150849150849" /psig="0.999000999001" /xcortree=3170 /SigmaFactorBS="tcgaagccaaagacatacatgatttgttaaaAATTGACTcag gaaatctgcttTTATATAATGGCATTGCAATataactaaaaatggttaatcacccttt a" /listShort="S519, ykuU, ykuV" /listLong="rok" /label="upshifts" CDS 1404589..1405131 /gene="ahpA" /locus_tag="BSU_14220" /old_locus_tag="BSU14220" /EC_number="1.11.1.-" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:22938038, 27683249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22938038, 27683249; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="biofilm-specific peroxidase; 2-cys peroxiredoxin" /protein_id="NP_389305.1" /db_xref="EnsemblGenomes-Gn:BSU14220" /db_xref="EnsemblGenomes-Tr:CAB13295" /db_xref="GOA:O34564" /db_xref="InterPro:IPR000866" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR019479" /db_xref="InterPro:IPR024706" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG13305" /db_xref="UniProtKB/Swiss-Prot:O34564" /translation="MAERMVGKQAPRFEMEAVLASKEFGKVSLEENMKNDKWTVLFFY PMDFTFVCPTEITAMSDRYDEFEDLDAEVIGVSTDTIHTHLAWINTDRKENGLGQLKY PLAADTNHEVSREYGVLIEEEGVALRGLFIINPEGELQYQTVFHNNIGRDVDETLRVL QALQTGGLCPANWKPGQKTL*" /label="ahpA CDS" gene 1404589..1405131 /gene="ahpA" /locus_tag="BSU_14220" /old_locus_tag="BSU14220" /label="ahpA gene" CDS 1405203..1405649 /gene="ykuV" /locus_tag="BSU_14230" /old_locus_tag="BSU14230" /EC_number="1.8.-.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15937154, 16132829, 16418167" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15937154, 16132829, 16418167; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thiol-disulfide oxidoreductase" /protein_id="NP_389306.2" /db_xref="EnsemblGenomes-Gn:BSU14230" /db_xref="EnsemblGenomes-Tr:CAB13296" /db_xref="GOA:O31699" /db_xref="InterPro:IPR000866" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="PDB:2B5X" /db_xref="PDB:2B5Y" /db_xref="SubtiList:BG13306" /db_xref="UniProtKB/Swiss-Prot:O31699" /translation="MKLRQPMPELTGEKAWLNGEVTREQLIGEKPTLIHFWSISCHLC KEAMPQVNEFRDKYQDQLNVVAVHMPRSEDDLDPGKIKETAAEHDITQPIFVDSDHAL TDAFENEYVPAYYVFDKTGQLRHFQAGGSGMKMLEKRVNRVLAETE*" /label="ykuV CDS" gene 1405203..1405649 /gene="ykuV" /locus_tag="BSU_14230" /old_locus_tag="BSU14230" /label="ykuV gene" downshifts 1405657 /Source="Nicolas_upshifts" /id="D796" /incds=0 /nref=58 /ntot=211 /MaxReadThrough="3.11112" /MaxDrop="4.73023" /score="10.8864177" /energy="-5.4" /TU="U1175" /idTUdmin="U1172" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1406042..1406049 /Source="Nicolas_upshift_promotors" /id="U1176" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.884115884115884" /psig=1 /xcortree=2393 /SigmaFactorBS="ttttcatagagtaaatataatagtaaaatgctaaaataatAG TTGATAaaattacttttgtaATCTAATATCTTAATTAAAGatgttaattttgataggg g" /listShort="rok" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1406062 /Source="Nicolas_upshifts" /id="U1176" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.884115884115884" /psig=1 /xcortree=2393 /SigmaFactorBS="ttttcatagagtaaatataatagtaaaatgctaaaataatAG TTGATAaaattacttttgtaATCTAATATCTTAATTAAAGatgttaattttgataggg g" /listShort="rok" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1406064..1406083 /Source="Nicolas_upshift_promotors" /id="U1176" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.884115884115884" /psig=1 /xcortree=2393 /SigmaFactorBS="ttttcatagagtaaatataatagtaaaatgctaaaataatAG TTGATAaaattacttttgtaATCTAATATCTTAATTAAAGatgttaattttgataggg g" /listShort="rok" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1406115..1406690 /gene="rok" /locus_tag="BSU_14240" /old_locus_tag="BSU14240" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15743949, 15819619, 27902860" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15743949, 15819619, 27902860; Product type r: regulator" /codon_start=1 /transl_table=11 /product="repressor of comK" /protein_id="NP_389307.1" /db_xref="EnsemblGenomes-Gn:BSU14240" /db_xref="EnsemblGenomes-Tr:CAB13297" /db_xref="GOA:O34857" /db_xref="SubtiList:BG13307" /db_xref="UniProtKB/Swiss-Prot:O34857" /translation="MFNEREALRLRLEQLNEAEVKVIREYQIERDKIYAKLRELDRNG SPSEIKKDFRSEKKPDSLPVLAELAAQEIRSYQPQSQQQSVQPQLQSISSLPAGIPDG TTRRRRGTARPGSKAAKLREAAIKTLKRHNAAIKSSELQKEIEKESGLEIPNMTTFMQ SLIKMYPEVKKPYRGQYILEGEIESAESANE*" /label="rok CDS" gene 1406115..1406690 /gene="rok" /locus_tag="BSU_14240" /old_locus_tag="BSU14240" /label="rok gene" downshifts 1406668 /Source="Nicolas_upshifts" /id="D797" /incds=0 /nref=246 /ntot=258 /MaxReadThrough="1.77207" /MaxDrop="6.35121" /score="17.7584572" /energy="-9" /TU="NA" /idTUdmin="U1176" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1406731..1407696) /gene="sppO" /locus_tag="BSU_14250" /old_locus_tag="BSU14250" /experiment="publication(s) with functional evidences, PMID:8990290, 15383836, 15743949" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8990290, 15383836, 15743949; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore protein cse15" /protein_id="NP_389308.1" /db_xref="EnsemblGenomes-Gn:BSU14250" /db_xref="EnsemblGenomes-Tr:CAB13298" /db_xref="GOA:O31700" /db_xref="SubtiList:BG12251" /db_xref="UniProtKB/Swiss-Prot:O31700" /translation="MKRSGPFFHDVSQENLYLKSELSRCHKLISELEASYFHQKNNKL LKENTDMKEKLQQLSAELTHMSTKEKHASHTSQTLHQIRAELLDKIVVLQELLSAETY KRRAEIEEKHKLHIAKVKIEEENKNLHKRISELQASIEQEQNALLQAKQQAELIKAEN GRLKEQMVEKEYQLKHIKIEVDHMKDRIIETKERLLDIEKTKEKLFHETIISYKRQLD ESDAWIASHFADIDGGTKQKEKTEEEAPAAYAQPNHVETILEDVTKQIHVLQKQLAHA QSSDQAKSHTIEELKNRAAEEKPYQKWVYKLNLEKENKPSQKKPQ*" /label="sppO CDS" gene complement(1406731..1407696) /gene="sppO" /locus_tag="BSU_14250" /old_locus_tag="BSU14250" /label="sppO gene" downshifts complement(1406744) /Source="Nicolas_upshifts" /id="D798" /incds=0 /nref=47 /ntot=67 /MaxReadThrough="2.24884" /MaxDrop="5.5936" /score="3.60334458" /energy="-7.2" /TU="NA" /idTUdmin="U1178" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1407040..1407041 /Source="Nicolas_upshift_promotors" /id="U1177" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.547452547452547" /psig="0.988011988011988" /xcortree=1801 /SigmaFactorBS="atatcggcaaaatgagaagcaatccaggcatcgctTTcatca agttgccgtttaTACGATATAATAGTTTCGTGaaataatttttctttcgttttttcta t" /listShort="S520, mobA, moeB, moeA, mobB, moaE, moaD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1407059..1407078 /Source="Nicolas_upshift_promotors" /id="U1177" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.547452547452547" /psig="0.988011988011988" /xcortree=1801 /SigmaFactorBS="atatcggcaaaatgagaagcaatccaggcatcgctTTcatca agttgccgtttaTACGATATAATAGTTTCGTGaaataatttttctttcgttttttcta t" /listShort="S520, mobA, moeB, moeA, mobB, moaE, moaD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1407065..1407789 /Source="Nicolas_S_feature" /locus_tag="new_1494737_1495461" /HighExp="dia15, Diami, dia5, H2O2, G135, G150, G180, LBGexp, Paraq, Lbexp" /AntisenseName="yknT" /AntisenseCor="-0.36512493899072102" /AntisenseRegPval="-9.1999999999999993" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S520" upshifts 1407065 /Source="Nicolas_upshifts" /id="U1177" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.547452547452547" /psig="0.988011988011988" /xcortree=1801 /SigmaFactorBS="atatcggcaaaatgagaagcaatccaggcatcgctTTcatca agttgccgtttaTACGATATAATAGTTTCGTGaaataatttttctttcgttttttcta t" /listShort="S520, mobA, moeB, moeA, mobB, moaE, moaD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1407717..1407735) /Source="Nicolas_upshift_promotors" /id="U1178" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1151 /SigmaFactorBS="aaaagcaaaggctcaacgctactgcttgtctgtttattaaag aGGAATAgctgttcagtatttGCATATTGTAGTGTTAACAtcatgagggagatggttc g" /listShort="yknT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1407738) /Source="Nicolas_upshifts" /id="U1178" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1151 /SigmaFactorBS="aaaagcaaaggctcaacgctactgcttgtctgtttattaaag aGGAATAgctgttcagtatttGCATATTGTAGTGTTAACAtcatgagggagatggttc g" /listShort="yknT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1407750..1407755) /Source="Nicolas_upshift_promotors" /id="U1178" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1151 /SigmaFactorBS="aaaagcaaaggctcaacgctactgcttgtctgtttattaaag aGGAATAgctgttcagtatttGCATATTGTAGTGTTAACAtcatgagggagatggttc g" /listShort="yknT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1407776..1407782 /Source="Nicolas_upshift_promotors" /id="U1179" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.442557442557443" /psig="0.99000999000999" /xcortree=2673 /SigmaFactorBS="atgcaaatactgaacagctattcctctttaataaacagacaa gcAGTAGCGttgagcctttgctTTTGCTATGCTTTTAACGAAactagaggtgagatga t" /listShort="mobA, moeB, moeA, mobB, moaE, moaD" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1407792 /Source="Nicolas_upshifts" /id="U1179" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.442557442557443" /psig="0.99000999000999" /xcortree=2673 /SigmaFactorBS="atgcaaatactgaacagctattcctctttaataaacagacaa gcAGTAGCGttgagcctttgctTTTGCTATGCTTTTAACGAAactagaggtgagatga t" /listShort="mobA, moeB, moeA, mobB, moaE, moaD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1407796..1407815 /Source="Nicolas_upshift_promotors" /id="U1179" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.442557442557443" /psig="0.99000999000999" /xcortree=2673 /SigmaFactorBS="atgcaaatactgaacagctattcctctttaataaacagacaa gcAGTAGCGttgagcctttgctTTTGCTATGCTTTTAACGAAactagaggtgagatga t" /listShort="mobA, moeB, moeA, mobB, moaE, moaD" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1407833..1408432 /gene="mobA" /locus_tag="BSU_14260" /old_locus_tag="BSU14260" /EC_number="2.7.7.77" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10978347; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="molybdopterin-guanine dinucleotide biosynthesis protein A" /protein_id="NP_389309.1" /db_xref="EnsemblGenomes-Gn:BSU14260" /db_xref="EnsemblGenomes-Tr:CAB13299" /db_xref="GOA:O31701" /db_xref="InterPro:IPR013482" /db_xref="InterPro:IPR025877" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG12621" /db_xref="UniProtKB/Swiss-Prot:O31701" /translation="MKHVNVLLAGGASRRFGEPKAFVKWKGRMLYECAKEALGEQTVI ISRPEFIDRFQENGENEVYQDAEPFQGMGPLAGIYTAFKKTDGDLYTVLSCDTPLIQR RTMLELKRLMIAGADAVVPISDGQVQPLIAIYHKRIMPVLYDQLSEKRLRISDLLGRI SVCYVQAENIGANPAEFININTRDDFSCLEEKSNSLKRD*" /label="mobA CDS" gene 1407833..1408432 /gene="mobA" /locus_tag="BSU_14260" /old_locus_tag="BSU14260" /label="mobA gene" CDS 1408483..1409502 /gene="moeB" /locus_tag="BSU_14270" /old_locus_tag="BSU14270" /EC_number="2.7.7.80" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 17223713; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="molybdopterin biosynthesis adenylyltransferase" /protein_id="NP_389310.1" /db_xref="EnsemblGenomes-Gn:BSU14270" /db_xref="EnsemblGenomes-Tr:CAB13300" /db_xref="GOA:O31702" /db_xref="InterPro:IPR000594" /db_xref="InterPro:IPR035985" /db_xref="SubtiList:BG12624" /db_xref="UniProtKB/Swiss-Prot:O31702" /translation="MEERYSRQIRFKQIGEEGQKRLADSHVLIVGAGALGTAGAEGLS RAGVGTITIIDRDYVEWSNLQRQQLYTESDAKLRMPKAMAAKEHLSAINSEIHIEAYV TEGTAETLEPLIEKADVVIDATDNFETRMLINDLAQKTKTPWVYGACVSSQGMFMTVI PGETPCLSCLFEQIPVGGATCDTAGIIPPAVHIVSAYQQAEALKLLTGQKEAIQRGFV TFDVWNNSHMKINVNHVRREECPSCGANAVYPYLQDWNTPKAAVLCGRDTVQVRSESL KRIPKQELIKRLKTIGKVEANAFLLHIFYEDFRIVIFNDGRALVHGTNDVKEANSVLA RVIGL*" /label="moeB CDS" gene 1408483..1409502 /gene="moeB" /locus_tag="BSU_14270" /old_locus_tag="BSU14270" /label="moeB gene" CDS 1409520..1410812 /gene="moeA" /locus_tag="BSU_14280" /old_locus_tag="BSU14280" /EC_number="2.10.1.1" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 11428898, 12006571, 18959753, 21206014; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="molybdate to molybdopterin ligation enzyme" /protein_id="NP_389311.1" /db_xref="EnsemblGenomes-Gn:BSU14280" /db_xref="EnsemblGenomes-Tr:CAB13301" /db_xref="GOA:O31703" /db_xref="InterPro:IPR001453" /db_xref="InterPro:IPR005110" /db_xref="InterPro:IPR005111" /db_xref="InterPro:IPR036135" /db_xref="InterPro:IPR036425" /db_xref="InterPro:IPR036688" /db_xref="SubtiList:BG12623" /db_xref="UniProtKB/Swiss-Prot:O31703" /translation="MLEKRTPIPVDEAVRRVCHFQKQGETEWVALEDSLHRFLAEDIT ADHHVPAFDRSPYDGFAVRACDTAEASRENPVRFEVIDHIGAGAVSEKELGPFQAVRI MTGAQIPEGADAVVMIELTQAFEENGKSFMSLKRRFQTGDNISKTGEDAQKGSVLLTK GTRVTPGVTALLATFGYASVPVVRKPVVGIIATGTELLNVSDPLEPGKIRNSNASMVY AQAIEAGATPLYLGKISDELDKSFAAVKEAMKKVDFLITTGGVSVGDFDFLPAIYEKL GADVLFNKVAMRPGSVTTVAHANDMLLFGLSGNPSACYVGFELFVKPIIQTWLLNETP HSICAEAVLTKDFPKPNPFTRFVRALVHHQEGKLLATPVGLDKSSSVTSLADANAFII LPGGTRGYESGRTVQVLLIREENGSEWPWSVLSRSSKL*" /label="moeA CDS" gene 1409520..1410812 /gene="moeA" /locus_tag="BSU_14280" /old_locus_tag="BSU14280" /label="moeA gene" CDS 1410773..1411294 /gene="mobB" /locus_tag="BSU_14290" /old_locus_tag="BSU14290" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 9219527, 12682065, 12719427; Product type c: carrier" /codon_start=1 /transl_table=11 /product="molybdopterin-guanine dinucleotide biosynthesis protein B" /protein_id="NP_389312.1" /db_xref="EnsemblGenomes-Gn:BSU14290" /db_xref="EnsemblGenomes-Tr:CAB13302" /db_xref="GOA:O31704" /db_xref="InterPro:IPR004435" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12622" /db_xref="UniProtKB/Swiss-Prot:O31704" /translation="MALVRPFPIVQVVGFQNSGKTTFIERILEKASEQGVHLGCLKHH GHGGEPQTLTEGKDTDRYKAAGADVTAVEGAGVLQLTARRNWDLARLIELYQFLETDC LLIEGFKKAPYPKVVILSEKEDLEALQAVNIIAIIYRKKEHMTEHQGLPVFHADDPVA VDFVLSQLKGESA*" /label="mobB CDS" gene 1410773..1411294 /gene="mobB" /locus_tag="BSU_14290" /old_locus_tag="BSU14290" /label="mobB gene" CDS 1411294..1411767 /gene="moaE" /locus_tag="BSU_14300" /old_locus_tag="BSU14300" /EC_number="2.8.1.12" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 11135669, 18092812; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="molybdopterin synthase (large subunit)" /protein_id="NP_389313.1" /db_xref="EnsemblGenomes-Gn:BSU14300" /db_xref="EnsemblGenomes-Tr:CAB13303" /db_xref="GOA:O31705" /db_xref="InterPro:IPR003448" /db_xref="InterPro:IPR036563" /db_xref="SubtiList:BG12620" /db_xref="UniProtKB/Swiss-Prot:O31705" /translation="MERFEITKTPINTENIIKKVEKREAGAITTFIGTVREWTNGKRT VRLEYEAYEPMAVQMLAQIGAEIEEKWEGASAAITHRIGVLDIGEAAVVIAVSSPHRK AAYEANEYAIERIKQIVPIWKKEIWEDGEQWIGDQLETTAYPNGKPDLSEGEQHD*" /label="moaE CDS" gene 1411294..1411767 /gene="moaE" /locus_tag="BSU_14300" /old_locus_tag="BSU14300" /label="moaE gene" CDS 1411760..1411993 /gene="moaD" /locus_tag="BSU_14310" /old_locus_tag="BSU14310" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 11135669, 17223713, 19946146; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="molybdopterin synthase (small subunit)" /protein_id="NP_389314.1" /db_xref="EnsemblGenomes-Gn:BSU14310" /db_xref="EnsemblGenomes-Tr:CAB13304" /db_xref="GOA:O31706" /db_xref="InterPro:IPR003749" /db_xref="InterPro:IPR010034" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR016155" /db_xref="SubtiList:BG12619" /db_xref="UniProtKB/Swiss-Prot:O31706" /translation="MIKILLFAGLAEQAGTQAIEIDMEQATTDEIKASLKEQYGLESI DTAMIAVNESYVKENTSVSSGDTVAIIPPVSGG*" /label="moaD CDS" gene 1411760..1411993 /gene="moaD" /locus_tag="BSU_14310" /old_locus_tag="BSU14310" /label="moaD gene" downshifts 1411972 /Source="Nicolas_upshifts" /id="D799" /incds=0 /nref=87 /ntot=240 /MaxReadThrough="1.14308" /MaxDrop="5.73073" /score="32.0123217" /energy="-16.9" /TU="NA" /idTUdmin="U1177" /TUdmin=2 /isTUend="TRUE" /label="downshifts" promotor_-35 1412038..1412043 /Source="Nicolas_upshift_promotors" /id="U1180" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=954 /SigmaFactorBS="ttcagccgtccggtttttctgtatttcattGGCATAtcccca agtatcctcaGCATACAATGATTTTCTGTaagcgtttattctacatatgttactccct a" /listShort="S521, yknU, yknV" /listLong="yknW, yknX, yknY, yknZ" /label="promotor_-35" promotor_-10 1412060..1412078 /Source="Nicolas_upshift_promotors" /id="U1180" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=954 /SigmaFactorBS="ttcagccgtccggtttttctgtatttcattGGCATAtcccca agtatcctcaGCATACAATGATTTTCTGTaagcgtttattctacatatgttactccct a" /listShort="S521, yknU, yknV" /listLong="yknW, yknX, yknY, yknZ" /label="promotor_-10" upshifts 1412068 /Source="Nicolas_upshifts" /id="U1180" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=954 /SigmaFactorBS="ttcagccgtccggtttttctgtatttcattGGCATAtcccca agtatcctcaGCATACAATGATTTTCTGTaagcgtttattctacatatgttactccct a" /listShort="S521, yknU, yknV" /listLong="yknW, yknX, yknY, yknZ" /label="upshifts" S_feature 1412080..1412166 /Source="Nicolas_S_feature" /locus_tag="new_1499752_1499838" /HighExp="S4, S5, S3, T5.0H, T4.0H, Pyr, S6, T3.30H, M9-stat, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S521" promotor_-35 1412156..1412159 /Source="Nicolas_upshift_promotors" /id="U1181" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.525474525474525" /psig="0.987012987012987" /xcortree=406 /SigmaFactorBS="ataaagtaagagactcactccataattagactgaaattttga aaaataATAGaaatttatttcgggTATCGATATAGTGAAGATGAtaaatgttggaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1412168 /Source="Nicolas_upshifts" /id="U1181" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.525474525474525" /psig="0.987012987012987" /xcortree=406 /SigmaFactorBS="ataaagtaagagactcactccataattagactgaaattttga aaaataATAGaaatttatttcgggTATCGATATAGTGAAGATGAtaaatgttggaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1412174..1412193 /Source="Nicolas_upshift_promotors" /id="U1181" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.525474525474525" /psig="0.987012987012987" /xcortree=406 /SigmaFactorBS="ataaagtaagagactcactccataattagactgaaattttga aaaataATAGaaatttatttcgggTATCGATATAGTGAAGATGAtaaatgttggaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1412217..1413974 /gene="yknU" /locus_tag="BSU_14320" /old_locus_tag="BSU14320" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_389315.1" /db_xref="EnsemblGenomes-Gn:BSU14320" /db_xref="EnsemblGenomes-Tr:CAB13305" /db_xref="GOA:O31707" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG13241" /db_xref="UniProtKB/Swiss-Prot:O31707" /translation="METFKRLKMYYWPYRKVFMWSLLAMLLMTAITVVYPIILQITID EIVLGRQYQLAAWVSLGFIAVMVLKGMATFFHQYLGDMFGIKSVYRLRNGLYEKLQRL SFSYYDNAKTGDLMSRLTADVEGLRFFLSYGLAELIRFGLLVAISLSVMFYYSVPLTL VTIAVLPFLAVAVYRFDKRVHPAFRGIRKSFAKLNTKVQENISGINTVKSLSREDFQI STFNKANAEYRAQYLQTSSIWSAYFPLMEFIGNTCIVALLSYGGYLVMQNQLNPGELV AFFSLVNYMMWPIMNLGFVINMFSQAKASGERLLDILEKEEDITDHPHALHKQKLTGD VHFKNVSLAYGKEQTNALCNVSFEANSGKVIGLLGPTGSGKSSVTQLLTRFYSPVGGM ITIDHKPITDYSLKTLRSNIGVVLQESFLFSSTIRSNISYGRPDASMEDVIEAAKRAQ AHNFIMELPDGYDTMLGERGMGLSGGQKQRIAIARAICLNPSILILDDATSAVDMQTE HSIQLALKEVMKNRTTFIVAHRISSLKHADEILVFNKGRIRERGTHHELLEKGGYYKK IYDLQYRDVKMINEPHEVG*" /label="yknU CDS" gene 1412217..1413974 /gene="yknU" /locus_tag="BSU_14320" /old_locus_tag="BSU14320" /label="yknU gene" CDS 1413986..1415800 /gene="yknV" /locus_tag="BSU_14330" /old_locus_tag="BSU14330" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_389316.1" /db_xref="EnsemblGenomes-Gn:BSU14330" /db_xref="EnsemblGenomes-Tr:CAB13306" /db_xref="GOA:O31708" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG13242" /db_xref="UniProtKB/Swiss-Prot:O31708" /translation="MKQAKKQGVLERFYYSSDEIIEKPFNWAQMWRLLSYVKPYRKTI LPLSFLTVLIGTAVKLVIPILIGVYVLDQAITGRNSELLIQLIFIISGLYVLNYAANV LRIRWMNQLGQHVIYDLRQHLFTHVQRLSHRFFDQRSAGSILVRIMNDINSLQELFTS GVINLLTDLLLLAGVIIILFTLSPELTIAIMVTLPIMFFISTSLRKKIRRSWQTVRLK QSKLNSHLNESIQGIRVTQAFTQEEENMAYFDGVNQENYESWREATRKNAMFRPLVEM TNAIGTAVLIWYGATLIMNETITIGVFVSFAFYLGMFWEPISRLGQVYNQLLMGMASS ERIFEFLDEQPNVKEKPNAIHNEKINGEISFEEVEFSYDEKRKALHAVSFSIPAGSTL ALVGHTGSGKTTIANLISRFYDAAGGTIKIDGIPIKDLSLASLRSQISIVLQDTFIFS GTIMENIRFGRPNASDEEVMKASQAVGADEFISDLAEGYATEVEERGSVLSAGQRQLI SFARALLADPAIIILDEATASIDTETEVKIQQALKTLLKGRTAVMIAHRLSTIRDADR IIVLDHGRKIEEGNHDQLLAKGGIYAGLVKAQYSTAIE*" /label="yknV CDS" gene 1413986..1415800 /gene="yknV" /locus_tag="BSU_14330" /old_locus_tag="BSU14330" /label="yknV gene" promotor_-10 complement(1414423..1414442) /Source="Nicolas_upshift_promotors" /id="U1182" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.63036963036963" /psig="0.954045954045954" /xcortree=1712 /SigmaFactorBS="gcaagtcggtcaacaaattgatgactccgCTTGTAAAgagct cctgaagagAGTTAATATCATTCATGATCctgactaagatcgatcccgccgaccgctg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1414433) /Source="Nicolas_upshifts" /id="U1182" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.63036963036963" /psig="0.954045954045954" /xcortree=1712 /SigmaFactorBS="gcaagtcggtcaacaaattgatgactccgCTTGTAAAgagct cctgaagagAGTTAATATCATTCATGATCctgactaagatcgatcccgccgaccgctg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1414457..1414464) /Source="Nicolas_upshift_promotors" /id="U1182" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.63036963036963" /psig="0.954045954045954" /xcortree=1712 /SigmaFactorBS="gcaagtcggtcaacaaattgatgactccgCTTGTAAAgagct cctgaagagAGTTAATATCATTCATGATCctgactaagatcgatcccgccgaccgctg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1415851..1415860 /Source="Nicolas_upshift_promotors" /id="U1183" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1690 /SigmaFactorBS="atattgaaggtttttggaaatttattagaaaaacaTGAAACT TTTtgatatccttcCCGTACTATTTGTTAGatattctcaaggaggttttgaaatggaa a" /listShort="yknW, yknX, yknY, yknZ, S522, fruR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1415872..1415887 /Source="Nicolas_upshift_promotors" /id="U1183" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1690 /SigmaFactorBS="atattgaaggtttttggaaatttattagaaaaacaTGAAACT TTTtgatatccttcCCGTACTATTTGTTAGatattctcaaggaggttttgaaatggaa a" /listShort="yknW, yknX, yknY, yknZ, S522, fruR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1415876 /Source="Nicolas_upshifts" /id="U1183" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1690 /SigmaFactorBS="atattgaaggtttttggaaatttattagaaaaacaTGAAACT TTTtgatatccttcCCGTACTATTTGTTAGatattctcaaggaggttttgaaatggaa a" /listShort="yknW, yknX, yknY, yknZ, S522, fruR" /GFF_Attribute="listLong" /label="upshifts" CDS 1415910..1416605 /gene="skiW" /locus_tag="BSU_14340" /old_locus_tag="BSU14340" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 22707703" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 22707703; Product type t: transporter" /codon_start=1 /transl_table=11 /product="subunit of permease exporting the starvation-induced killing protein" /protein_id="NP_389317.1" /db_xref="EnsemblGenomes-Gn:BSU14340" /db_xref="EnsemblGenomes-Tr:CAB13307" /db_xref="GOA:O31709" /db_xref="InterPro:IPR006977" /db_xref="SubtiList:BG13243" /db_xref="UniProtKB/Swiss-Prot:O31709" /translation="METNVEKNSGTATEKPSLFGVITSPSVQFERIRERPAVWGPLLI VAAIIIVGAVLQSLGTDYSELLKSQDTQGLSAEQMETVATITKFGGMAGAIIGGIAAL FIAPLIYWLCVKVSGGVTTYKKMLSLSLFVSLISSLGLLVNGIVAFTTDVNPLYSTTS LAGIIPSDGALASVLNTFEIFSIWSFVLLAIGLHKTGGISKKAGWISAIILFGILVVF SLFSGLINSVAGA*" /label="skiW CDS" gene 1415910..1416605 /gene="skiW" /locus_tag="BSU_14340" /old_locus_tag="BSU14340" /label="skiW gene" CDS 1416610..1417743 /gene="skiX" /locus_tag="BSU_14350" /old_locus_tag="BSU14350" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11544226, 22707703" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11544226, 22707703; Product type t: transporter" /codon_start=1 /transl_table=11 /product="subunit of efflux permease exporting the starvation-induced killing protein" /protein_id="NP_389318.1" /db_xref="EnsemblGenomes-Gn:BSU14350" /db_xref="EnsemblGenomes-Tr:CAB13308" /db_xref="GOA:O31710" /db_xref="InterPro:IPR006143" /db_xref="InterPro:IPR032317" /db_xref="SubtiList:BG13244" /db_xref="UniProtKB/Swiss-Prot:O31710" /translation="MKKVWIGIGIAVIVALFVGINIYRSAAPTSGSAGKEVQTGSVEE NEISSTVMVPGTLKFSNEQYVFYEADKGTLEDIKVKEGDKVKKGTALVTYTNEQLSLE KEQNQLTSESNRLQIDQIQEKLKALDSKERELEKQVGKKEAEKQIESERTELQMQKKT AEIELKQTELQRQSLANRVSDLEVKSEIEGTVISVNQEAASKKSDIQEPVIHIGNPKD LVVSGKLSEYDTLKVKKGQKVTLTSDVIQGKTWKGTVSAVGLVPDQQESAAAQGTEQA VQYPLQVKIKGNLPEGKPGFKFIMNIETDKRKANTLPSKAVKKEDDQYYVYTVKDGKA KRVDVKIGEVTDDLTEIKEGLTQDDQVILNPSDQVTDGMEVKS*" /label="skiX CDS" gene 1416610..1417743 /gene="skiX" /locus_tag="BSU_14350" /old_locus_tag="BSU14350" /label="skiX gene" CDS 1417744..1418436 /gene="skiY" /locus_tag="BSU_14360" /old_locus_tag="BSU14360" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9987136, 22707703" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9987136, 22707703; Product type t: transporter" /codon_start=1 /transl_table=11 /product="subunit of efflux permease exporting the starvation-induced killing protein (ATP-binding protein)" /protein_id="NP_389319.1" /db_xref="EnsemblGenomes-Gn:BSU14360" /db_xref="EnsemblGenomes-Tr:CAB13309" /db_xref="GOA:O31711" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13245" /db_xref="UniProtKB/Swiss-Prot:O31711" /translation="MIQLSNVRKSYQIGKETFDVLHSIDLDIHQGEYVSIMGPSGSGK STIMNIIGCLDRPTSGTYQLDGEDISSYKDKELAAVRNRSIGFVFQQFQLLPRLNAKK NVELPMIYSGIGKKERQERAERALEKVGLADRMLHMPNELSGGQKQRVAIARAIVNEP KLILADEPTGALDTKTSEAIMDQFTALNAEGTTIVLVTHEPEVADCTNRIVMVRDGNI VPASSGQRSVGE*" /label="skiY CDS" gene 1417744..1418436 /gene="skiY" /locus_tag="BSU_14360" /old_locus_tag="BSU14360" /label="skiY gene" CDS 1418433..1419626 /gene="skiZ" /locus_tag="BSU_14370" /old_locus_tag="BSU14370" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9987136, 22707703, 22720735, 27243566" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9987136, 22707703, 22720735, 27243566; Product type t: transporter" /codon_start=1 /transl_table=11 /product="permease subunit exporting Sporulation-Delaying Protein" /protein_id="NP_389320.1" /db_xref="EnsemblGenomes-Gn:BSU14370" /db_xref="EnsemblGenomes-Tr:CAB13310" /db_xref="GOA:O31712" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR005085" /db_xref="InterPro:IPR025857" /db_xref="SubtiList:BG13246" /db_xref="UniProtKB/Swiss-Prot:O31712" /translation="MSLLENIRMALSSVLAHKMRSILTMLGIIIGVGSVIVVVAVGQG GEQMLKQSISGPGNTVELYYMPSDEELASNPNAAAESTFTENDIKGLKGIEGIKQVVA STSESMKARYHEEETDATVNGINDGYMNVNSLKIESGRTFTDNDFLAGNRVGIISQKM AKELFDKTSPLGEVVWINGQPVEIIGVLKKVTGLLSFDLSEMYVPFNMMKSSFGTSDF SNVSLQVESADDIKSAGKEAAQLVNDNHGTEDSYQVMNMEEIAAGIGKVTAIMTTIIG SIAGISLLVGGIGVMNIMLVSVTERTREIGIRKSLGATRGQILTQFLIESVVLTLIGG LVGIGIGYGGAALVSAIAGWPSLISWQVVCGGVLFSMLIGVIFGMLPANKAAKLDPIE ALRYE*" /label="skiZ CDS" gene 1418433..1419626 /gene="skiZ" /locus_tag="BSU_14370" /old_locus_tag="BSU14370" /label="skiZ gene" downshifts 1419604 /Source="Nicolas_upshifts" /id="D800" /incds=0 /nref=79 /ntot=210 /MaxReadThrough="3.49546" /MaxDrop="4.46952" /score="36.2703425" /energy="-12.1" /TU="U1183" /idTUdmin="U1183" /TUdmin="-396" /isTUend="FALSE" /label="downshifts" promotor_-35 1419675..1419681 /Source="Nicolas_upshift_promotors" /id="U1184" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.86013986013986" /psig="0.86013986013986" /xcortree=1212 /SigmaFactorBS="tgaggtttttttatgtttagtgatttctactaTGAATATaaa agacttttttCATTAAAATAAGaagaaaatgtcgtacaattgtccttatttttgtcga a" /listShort="S522, fruR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1419695..1419706 /Source="Nicolas_upshift_promotors" /id="U1184" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.86013986013986" /psig="0.86013986013986" /xcortree=1212 /SigmaFactorBS="tgaggtttttttatgtttagtgatttctactaTGAATATaaa agacttttttCATTAAAATAAGaagaaaatgtcgtacaattgtccttatttttgtcga a" /listShort="S522, fruR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1419703 /Source="Nicolas_upshifts" /id="U1184" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.86013986013986" /psig="0.86013986013986" /xcortree=1212 /SigmaFactorBS="tgaggtttttttatgtttagtgatttctactaTGAATATaaa agacttttttCATTAAAATAAGaagaaaatgtcgtacaattgtccttatttttgtcga a" /listShort="S522, fruR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1419748..1419755 /Source="Nicolas_upshift_promotors" /id="U1185" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.87012987012987" /psig="0.967032967032967" /xcortree=1 /SigmaFactorBS="gtcgtacaattgtccttatttttgtcgaatttaCAGTTTACa aaccctatagacaTACGTTAATATGGAGAAACGtgaaagattttgatagttattgaat g" /listShort="S522, fruR, fruK, fruA" /listLong="sipT" /label="promotor_-35" promotor_-10 1419770..1419789 /Source="Nicolas_upshift_promotors" /id="U1185" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.87012987012987" /psig="0.967032967032967" /xcortree=1 /SigmaFactorBS="gtcgtacaattgtccttatttttgtcgaatttaCAGTTTACa aaccctatagacaTACGTTAATATGGAGAAACGtgaaagattttgatagttattgaat g" /listShort="S522, fruR, fruK, fruA" /listLong="sipT" /label="promotor_-10" S_feature 1419775..1419866 /Source="Nicolas_S_feature" /locus_tag="new_1507447_1507538" /HighExp="UNK1, LPh, HPh, Fru, G180, MG 5, C30, G135, MG t5, MG 10" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF, SigWXY" /TUshortPSig="0.967, 0.86, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S522" upshifts 1419775 /Source="Nicolas_upshifts" /id="U1185" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.87012987012987" /psig="0.967032967032967" /xcortree=1 /SigmaFactorBS="gtcgtacaattgtccttatttttgtcgaatttaCAGTTTACa aaccctatagacaTACGTTAATATGGAGAAACGtgaaagattttgatagttattgaat g" /listShort="S522, fruR, fruK, fruA" /listLong="sipT" /label="upshifts" promotor_-35 1419830..1419837 /Source="Nicolas_upshift_promotors" /id="U1186" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.814185814185814" /psig="0.999000999001" /xcortree=2 /SigmaFactorBS="attgaatgaatttgaatgatttTAGTTGCCtaaaccgaaaat aGCGTTTACAATGAAATTGTAttcaaaatgaatacgttttcattaggaggtgaagcat g" /listShort="fruR, fruK, fruA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1419851..1419870 /Source="Nicolas_upshift_promotors" /id="U1186" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.814185814185814" /psig="0.999000999001" /xcortree=2 /SigmaFactorBS="attgaatgaatttgaatgatttTAGTTGCCtaaaccgaaaat aGCGTTTACAATGAAATTGTAttcaaaatgaatacgttttcattaggaggtgaagcat g" /listShort="fruR, fruK, fruA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1419868 /Source="Nicolas_upshifts" /id="U1186" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.814185814185814" /psig="0.999000999001" /xcortree=2 /SigmaFactorBS="attgaatgaatttgaatgatttTAGTTGCCtaaaccgaaaat aGCGTTTACAATGAAATTGTAttcaaaatgaatacgttttcattaggaggtgaagcat g" /listShort="fruR, fruK, fruA" /GFF_Attribute="listLong" /label="upshifts" CDS 1419906..1420661 /gene="fruR" /locus_tag="BSU_14380" /old_locus_tag="BSU14380" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14563858; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (DeoR family)" /protein_id="NP_389321.1" /db_xref="EnsemblGenomes-Gn:BSU14380" /db_xref="EnsemblGenomes-Tr:CAB13311" /db_xref="GOA:O31713" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR014036" /db_xref="InterPro:IPR018356" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12589" /db_xref="UniProtKB/Swiss-Prot:O31713" /translation="MLTPERHQLIIDQIEKHDVVKIQELINLTNASESTIRRDLSTLE ERGFLKRVHGGAAKLSDIRLEPDMLEKSSKNLHDKLKIAEKAASLLEEGDCIYLDAGT TTLHMIDFMDKTKDIVVVTNGVMHIDALIRKEISFYLLGGYVKHRTGAIIGGASLVAM DQYRFDKSFLGTNGVHTEAGFTTPDPDEALLKQKAIKQAKHAYVLADPSKFGEISFSA FAGIGDATIITTDAEELTFDNYQEKTVVKVVKP*" /label="fruR CDS" gene 1419906..1420661 /gene="fruR" /locus_tag="BSU_14380" /old_locus_tag="BSU14380" /label="fruR gene" upshifts complement(1420054) /Source="Nicolas_upshifts" /id="U1187" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.74925074925075" /psig="0.015984015984016" /xcortree=3 /SigmaFactorBS="tcaagcatatcgggttcaagtctgatatcggaaagcttGgcc gctccaccatgaacGCGctttaaaaaaccgcgttcttcaagggtcgataaatctcttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1420056..1420058) /Source="Nicolas_upshift_promotors" /id="U1187" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.74925074925075" /psig="0.015984015984016" /xcortree=3 /SigmaFactorBS="tcaagcatatcgggttcaagtctgatatcggaaagcttGgcc gctccaccatgaacGCGctttaaaaaaccgcgttcttcaagggtcgataaatctcttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1420658..1421569 /gene="fruK" /locus_tag="BSU_14390" /old_locus_tag="BSU14390" /EC_number="2.7.1.56" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 168069, 14563858, 24328040; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fructose-1-phosphate kinase" /protein_id="NP_389322.1" /db_xref="EnsemblGenomes-Gn:BSU14390" /db_xref="EnsemblGenomes-Tr:CAB13312" /db_xref="GOA:O31714" /db_xref="InterPro:IPR002173" /db_xref="InterPro:IPR011611" /db_xref="InterPro:IPR017583" /db_xref="InterPro:IPR022463" /db_xref="InterPro:IPR023314" /db_xref="InterPro:IPR029056" /db_xref="SubtiList:BG12588" /db_xref="UniProtKB/Swiss-Prot:O31714" /translation="MIYTVTLNPSVDYIVHVEDFTVGGLNRSSYDTKYPGGKGINVSR LLKRHHVASKALGFVGGFTGEYIKTFLREENLETAFSEVKGDTRINVKLKTGDETEIN GQGPTISDEDFKAFLEQFQSLQEGDIVVLAGSIPSSLPHDTYEKIAEACKQQNARVVL DISGEALLKATEMKPFLMKPNHHELGEMFGTAITSVEEAVPYGKKLVEQGAEHVIVSM AGDGALLFTNEAVYFANVPKGKLVNSVGAGDSVVAGFLAGISKQLPLEEAFRLGVTSG SATAFSEELGTEEFVQQLLPEVKVTRL*" /label="fruK CDS" gene 1420658..1421569 /gene="fruK" /locus_tag="BSU_14390" /old_locus_tag="BSU14390" /label="fruK gene" CDS 1421584..1423491 /gene="fruA" /locus_tag="BSU_14400" /old_locus_tag="BSU14400" /EC_number="2.7.1.202" /function="16.11: Scavenge (Catabolism)" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:118007, 200418" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 118007, 200418; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) fructose-specific enzyme IIABC component" /protein_id="NP_389323.1" /db_xref="EnsemblGenomes-Gn:BSU14400" /db_xref="EnsemblGenomes-Tr:CAB13313" /db_xref="GOA:P71012" /db_xref="InterPro:IPR002178" /db_xref="InterPro:IPR003353" /db_xref="InterPro:IPR003501" /db_xref="InterPro:IPR004715" /db_xref="InterPro:IPR006327" /db_xref="InterPro:IPR013011" /db_xref="InterPro:IPR013014" /db_xref="InterPro:IPR016152" /db_xref="InterPro:IPR036095" /db_xref="PDB:2R4Q" /db_xref="SubtiList:BG11938" /db_xref="UniProtKB/Swiss-Prot:P71012" /translation="MKITELLTKHTIKLNIESKEKENVIDEMVTVLDKAGKLNDRQAY KEAILNRESQSSTGIGEGIAIPHAKTASVINPAIAFGRSKDGVDYESLDGQPAHLVFM IAATEGANNTHLEALSRLSTLLMREEIRKQLLEAESEDAIIDIINQHDKDDDEEEEEE EAAPAPAGKGKILAVTACPTGIAHTFMAADALKEKAKELGVEIKVETNGSSGIKHKLT AQEIEDAPAIIVAADKQVEMERFKGKRVLQVPVTAGIRRPQELIEKAMNQDAPIYQGS GGGSAASNDDEEAKGKSGSGIGNTFYKHLMSGVSNMLPFVVGGGILVAISFFWGIHSA DPNDPSYNTFAAALNFIGGDNALKLIVAVLAGFIAMSIADRPGFAPGMVGGFMATQAN AGFLGGLIAGFLAGYVVILLKKVFTFIPQSLDGLKPVLIYPLFGIFITGVLMQFVVNT PVAAFMNFLTNWLESLGTGNLVLMGIILGGMMAIDMGGPLNKAAFTFGIAMIDAGNYA PHAAIMAGGMVPPLGIALATTIFRNKFTQRDREAGITCYFMGAAFVTEGAIPFAAADP LRVIPAAVVGAAVAGGLTEFFRVTLPAPHGGVFVAFITNHPMLYLLSIVIGAVVMAII LGIVKKPVTEK*" /label="fruA CDS" gene 1421584..1423491 /gene="fruA" /locus_tag="BSU_14400" /old_locus_tag="BSU14400" /label="fruA gene" downshifts 1423476 /Source="Nicolas_upshifts" /id="D801" /incds=0 /nref=133 /ntot=228 /MaxReadThrough="3.99928" /MaxDrop="5.27169" /score="11.7516734" /energy="-11.4" /TU="U1185" /idTUdmin="U1186" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1423560..1423567 /Source="Nicolas_upshift_promotors" /id="U1188" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=1910 /SigmaFactorBS="gctttttcttatccggccggcagggagcgcggttaagttATG TATTTtattctttttTATGATAAAGTAAAAGAAGAgaaacaactgacatagcaattgt c" /listShort="sipT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1423578..1423597 /Source="Nicolas_upshift_promotors" /id="U1188" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=1910 /SigmaFactorBS="gctttttcttatccggccggcagggagcgcggttaagttATG TATTTtattctttttTATGATAAAGTAAAAGAAGAgaaacaactgacatagcaattgt c" /listShort="sipT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1423581 /Source="Nicolas_upshifts" /id="U1188" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=1910 /SigmaFactorBS="gctttttcttatccggccggcagggagcgcggttaagttATG TATTTtattctttttTATGATAAAGTAAAAGAAGAgaaacaactgacatagcaattgt c" /listShort="sipT" /GFF_Attribute="listLong" /label="upshifts" CDS 1423636..1424217 /gene="sipT" /locus_tag="BSU_14410" /old_locus_tag="BSU14410" /EC_number="3.4.21.89" /function="16.1: Circulate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9325333, 10198007, 11283286, 11807061, 12897006, 27159567" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9325333, 10198007, 11283286, 11807061, 12897006, 27159567; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="type I signal peptidase" /protein_id="NP_389324.1" /db_xref="EnsemblGenomes-Gn:BSU14410" /db_xref="EnsemblGenomes-Tr:CAB13314" /db_xref="GOA:P71013" /db_xref="InterPro:IPR000223" /db_xref="InterPro:IPR015927" /db_xref="InterPro:IPR019756" /db_xref="InterPro:IPR019757" /db_xref="InterPro:IPR019758" /db_xref="InterPro:IPR036286" /db_xref="SubtiList:BG11977" /db_xref="UniProtKB/Swiss-Prot:P71013" /translation="MTEEKNTNTEKTAKKKTNTYLEWGKAIVIAVLLALLIRHFLFEP YLVEGSSMYPTLHDGERLFVNKTVNYIGELKRGDIVIINGETSKIHYVKRLIGKPGET VQMKDDTLYINGKKVAEPYLSKNKKEAEKLGVSLTGDFGPVKVPKGKYFVMGDNRLNS MDSRNGLGLIAEDRIVGTSKFVFFPFNEMRQTK*" /label="sipT CDS" gene 1423636..1424217 /gene="sipT" /locus_tag="BSU_14410" /old_locus_tag="BSU14410" /label="sipT gene" downshifts 1424202 /Source="Nicolas_upshifts" /id="D802" /incds=0 /nref=90 /ntot=226 /MaxReadThrough="3.7981" /MaxDrop="6.13957" /score="5.03270493" /energy="-9.8" /TU="U1188" /idTUdmin="U1188" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" downshifts 1424246 /Source="Nicolas_upshifts" /id="D803" /incds=0 /nref=1 /ntot=29 /MaxReadThrough="2.6676" /MaxDrop="3.60225" /score="5.03270493" /energy="-9.8" /TU="NA" /idTUdmin="U1188" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1424251..1424520) /gene="ykoA" /locus_tag="BSU_14420" /old_locus_tag="BSU14420" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein of unknown function" /protein_id="NP_389325.1" /db_xref="EnsemblGenomes-Gn:BSU14420" /db_xref="EnsemblGenomes-Tr:CAB13315" /db_xref="GOA:O31715" /db_xref="SubtiList:BG13247" /db_xref="UniProtKB/Swiss-Prot:O31715" /translation="MRLLTLTEYCLLIFFTGFYLAVTGFTAKDIGLYIGIALIYIFSH IFSKRLLEKRGKENKQVHLFFSVLAIIGSVFITVLCIALVASFSK*" /label="ykoA CDS" gene complement(1424251..1424520) /gene="ykoA" /locus_tag="BSU_14420" /old_locus_tag="BSU14420" /label="ykoA gene" downshifts complement(1424256) /Source="Nicolas_upshifts" /id="D804" /incds=0 /nref=38 /ntot=254 /MaxReadThrough="2.08491" /MaxDrop="5.70938" /score="11.210199" /energy="-9.8" /TU="U1189" /idTUdmin="U1189" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" S_feature complement(1424521..1424586) /Source="Nicolas_S_feature" /locus_tag="new_1512193_1512258_c" /HighExp="LoTm, Gly, Lbstat, Sw, Cold, C30, HPh, S0, T0.30H, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S523" misc_feature complement(1424567..1424586) /Source="Nicolas_upshift_promotors" /id="U1189" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.85914085914086" /psig="0.999000999001" /xcortree=2176 /SigmaFactorBS="aagagaaatgattccctgataaaacagagagaaaacacttat acacccaaaccagccagcTGTGTTACAATTAAAGAGAGagaatgcatccgcctggaaa a" /listShort="S523, ykoA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1424586) /Source="Nicolas_upshifts" /id="U1189" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.85914085914086" /psig="0.999000999001" /xcortree=2176 /SigmaFactorBS="aagagaaatgattccctgataaaacagagagaaaacacttat acacccaaaccagccagcTGTGTTACAATTAAAGAGAGagaatgcatccgcctggaaa a" /listShort="S523, ykoA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1424639..1424646 /Source="Nicolas_upshift_promotors" /id="U1190" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2141 /SigmaFactorBS="gtgtataagtgttttctctctgttttatcagggaatcaTTTC TCTTgccctgcattCATGGTATACTTTTATTGATgatagacatgatggaggataataa a" /listShort="ykpA, panE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1424657..1424676 /Source="Nicolas_upshift_promotors" /id="U1190" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2141 /SigmaFactorBS="gtgtataagtgttttctctctgttttatcagggaatcaTTTC TCTTgccctgcattCATGGTATACTTTTATTGATgatagacatgatggaggataataa a" /listShort="ykpA, panE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1424661 /Source="Nicolas_upshifts" /id="U1190" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2141 /SigmaFactorBS="gtgtataagtgttttctctctgttttatcagggaatcaTTTC TCTTgccctgcattCATGGTATACTTTTATTGATgatagacatgatggaggataataa a" /listShort="ykpA, panE" /GFF_Attribute="listLong" /label="upshifts" CDS 1424701..1426323 /gene="ykpA" /locus_tag="BSU_14430" /old_locus_tag="BSU14430" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10816464, 24389466; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative energy-sensing inhibitor of translation" /protein_id="NP_389326.1" /db_xref="EnsemblGenomes-Gn:BSU14430" /db_xref="EnsemblGenomes-Tr:CAB13316" /db_xref="GOA:O31716" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032781" /db_xref="SubtiList:BG13270" /db_xref="UniProtKB/Swiss-Prot:O31716" /translation="MIAVNNVSLRFADRKLFEDVNIKFTPGNCYGLIGANGAGKSTFL KVLSGEIEPQTGDVHMSPGERLAVLKQNHFEYEEYEVLKVVIMGHKRLYEVMQEKDAI YMKPDFSDEDGIRAAELEGEFAELNGWEAESEAAILLKGLGISEDLHTKKMADLGGSE KVKVLLAQALFGKPDVLLLDEPTNHLDLQAIQWLEEFLINFENTVIVVSHDRHFLNKV CTHIADLDFNKIQIYVGNYDFWYESSQLALKLSQEANKKKEEQIKQLQEFVARFSANA SKSKQATSRKKLLEKITLDDIKPSSRRYPYVNFTPEREIGNDVLRVEGLTKTIDGVKV LDNVSFIMNREDKIAFTGRNELAVTTLFKIISGEMEADSGTFKWGVTTSQAYFPKDNS EYFEGSDLNLVDWLRQYSPHDQSESFLRGFLGRMLFSGEEVHKKANVLSGGEKVRCML SKAMLSGANILILDEPTNHLDLESITALNNGLISFKGAMLFTSHDHQFVQTIANRIIE ITPNGIVDKQMSYDEFLENADVQKKLTELYAE*" /label="ykpA CDS" gene 1424701..1426323 /gene="ykpA" /locus_tag="BSU_14430" /old_locus_tag="BSU14430" /label="ykpA gene" downshifts 1426311 /Source="Nicolas_upshifts" /id="D805" /incds=0 /nref=45 /ntot=239 /MaxReadThrough="5.13671" /MaxDrop="3.6227" /score="17.6386925" /energy="-7.6" /TU="U1190" /idTUdmin="U1190" /TUdmin="-993" /isTUend="FALSE" /label="downshifts" CDS 1426380..1427291 /gene="panE" /locus_tag="BSU_14440" /old_locus_tag="BSU14440" /EC_number="1.1.1.169" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1844812, 15966718, 17229734; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-dehydropantoate reductase" /protein_id="NP_389327.1" /db_xref="EnsemblGenomes-Gn:BSU14440" /db_xref="EnsemblGenomes-Tr:CAB13317" /db_xref="GOA:O31717" /db_xref="InterPro:IPR003710" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR013332" /db_xref="InterPro:IPR013752" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13271" /db_xref="UniProtKB/Swiss-Prot:O31717" /translation="MKFLVVGAGGVGGYIGGRLSEKGNDVTFLVRQKRAEQLKKTGLV IHSEKGNVSFQPELISAGETGQFDVVIIASKAYSLGQVIEDVKPFIHQESVIIPFLNG YRHYEQLFAAFSKEQVLGGLCFIESALDNKGEIHHTSASHRFVFGEWNGERTERIRAL EEAFSGVKAEVIISGHIEKDIWKKYLFIAAQAGITTLFQRPLGPILATEAGRHTAQTL IGEICTVLRKEGVPADPALEEESFRTMTSMSYHMKSSMLRDMENGQTTEGDHLHGFLI EKAKRLSLAAPVLETVYANLQMYEAEK*" /label="panE CDS" gene 1426380..1427291 /gene="panE" /locus_tag="BSU_14440" /old_locus_tag="BSU14440" /label="panE gene" downshifts 1427296 /Source="Nicolas_upshifts" /id="D806" /incds=0 /nref=120 /ntot=228 /MaxReadThrough="2.04919" /MaxDrop="4.55439" /score="11.4959806" /energy="-9.6" /TU="NA" /idTUdmin="U1190" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" CDS complement(1427325..1428557) /gene="ampS" /locus_tag="BSU_14450" /old_locus_tag="BSU14450" /EC_number="3.4.11.24" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9362117, 16088219, 22808738" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9362117, 16088219, 22808738; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aminopeptidase" /protein_id="NP_389328.1" /db_xref="EnsemblGenomes-Gn:BSU14450" /db_xref="EnsemblGenomes-Tr:CAB13318" /db_xref="GOA:P39762" /db_xref="InterPro:IPR000787" /db_xref="InterPro:IPR035097" /db_xref="SubtiList:BG10986" /db_xref="UniProtKB/Swiss-Prot:P39762" /translation="MDSFSQKLNTYAQLAVEVGVNVQKGQYVVVNASTDVRDFVRLIV KHAYEKGAKNVTVNWQDDEVAKLKYELAPFEAFEEYPEWEAKGREELAKNGAAFISVV SSNPDLLKGIDSKRIAAFQKAAGKALHTYRQYIQSDKVSWTVVGAASAGWAHKVFPGK SEEEAIHLLWEEIFKATRVNEDNPVQAWINHDQNLHEKVDHLNERHYAALHYQAEGTD LTIKLPRKHVWAGAGSVNESGHEFMANMPTEEVFTLPQKDGVDGVVSSTKPLSYGGNI IENFTLTFENGRIVDIKAEKGEDILKELVETDEGSHYLGEVALVPYDSPISQSNILFY NTLFDENASNHLAIGSAYAFNIEGGKQMSREELVKEGLNESITHVDFMIGSKDMNIDG ITADGKREPIFRNGNWAF*" /label="ampS CDS" gene complement(1427325..1428557) /gene="ampS" /locus_tag="BSU_14450" /old_locus_tag="BSU14450" /label="ampS gene" downshifts complement(1427336) /Source="Nicolas_upshifts" /id="D807" /incds=0 /nref=215 /ntot=254 /MaxReadThrough="1.34101" /MaxDrop="5.7635" /score="40.7811053" /energy="-9.6" /TU="NA" /idTUdmin="U1191" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1428575..1428594) /Source="Nicolas_upshift_promotors" /id="U1191" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.454545454545455" /psig="0.982017982017982" /xcortree=2338 /SigmaFactorBS="aaaacccaagacgtgtcgttttgggtttttcactttgggctc cttCTTTCCtttataggatcataTTTGATATGATGAGAAAAAAgcttggaggaatgat t" /listShort="ampS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1428599) /Source="Nicolas_upshifts" /id="U1191" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.454545454545455" /psig="0.982017982017982" /xcortree=2338 /SigmaFactorBS="aaaacccaagacgtgtcgttttgggtttttcactttgggctc cttCTTTCCtttataggatcataTTTGATATGATGAGAAAAAAgcttggaggaatgat t" /listShort="ampS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1428609..1428614) /Source="Nicolas_upshift_promotors" /id="U1191" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.454545454545455" /psig="0.982017982017982" /xcortree=2338 /SigmaFactorBS="aaaacccaagacgtgtcgttttgggtttttcactttgggctc cttCTTTCCtttataggatcataTTTGATATGATGAGAAAAAAgcttggaggaatgat t" /listShort="ampS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1428667..1428801) /gene="ykpC" /locus_tag="BSU_14460" /old_locus_tag="BSU14460" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389329.1" /db_xref="EnsemblGenomes-Gn:BSU14460" /db_xref="EnsemblGenomes-Tr:CAB13319" /db_xref="InterPro:IPR035379" /db_xref="SubtiList:BG11812" /db_xref="UniProtKB/Swiss-Prot:Q45492" /translation="MLRDLGRRVAIAAILSGIILGGMSISLANMPHSPAGGTVKLNHP *" /label="ykpC CDS" gene complement(1428667..1428801) /gene="ykpC" /locus_tag="BSU_14460" /old_locus_tag="BSU14460" /label="ykpC gene" downshifts complement(1428678) /Source="Nicolas_upshifts" /id="D808" /incds=0 /nref=51 /ntot=151 /MaxReadThrough="3.10365" /MaxDrop="5.04142" /score="-2.2377884" /energy="-9.1" /TU="U1192" /idTUdmin="U1193" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1428823..1428841) /Source="Nicolas_upshift_promotors" /id="U1192" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.863136863136863" /psig="0.863136863136863" /xcortree=1021 /SigmaFactorBS="ccgcaaaattctcacacgcggcaaatttcttgCTTCTTtttt cctcacttcctTCATATTGTGGGAAATGGAgaaacgttaaggaggaaacagatgctaa g" /listShort="ykpC, ampS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1428834) /Source="Nicolas_upshifts" /id="U1192" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.863136863136863" /psig="0.863136863136863" /xcortree=1021 /SigmaFactorBS="ccgcaaaattctcacacgcggcaaatttcttgCTTCTTtttt cctcacttcctTCATATTGTGGGAAATGGAgaaacgttaaggaggaaacagatgctaa g" /listShort="ykpC, ampS" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1428836..1428901) /Source="Nicolas_S_feature" /locus_tag="new_1516508_1516573_c" /HighExp="HiTm, C30, Lbstat, MG-0.2, BC, G135, MG 15, MG 10, MG-0.1, MG 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigI" /TUshortPSig="0.982" /TUlongSig="NA" /TUlongPSig="NA" /label="S524" promotor_-35 complement(1428857..1428862) /Source="Nicolas_upshift_promotors" /id="U1192" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.863136863136863" /psig="0.863136863136863" /xcortree=1021 /SigmaFactorBS="ccgcaaaattctcacacgcggcaaatttcttgCTTCTTtttt cctcacttcctTCATATTGTGGGAAATGGAgaaacgttaaggaggaaacagatgctaa g" /listShort="ykpC, ampS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1428902..1429909) /gene="mreBH" /locus_tag="BSU_14470" /old_locus_tag="BSU14470" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16950129, 19643765, 19659933, 21091501, 21636651, 26091431" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16950129, 19643765, 19659933, 21091501, 21636651, 26091431; Product type f : factor" /codon_start=1 /transl_table=11 /product="cell-shape determining protein" /protein_id="NP_389330.1" /db_xref="EnsemblGenomes-Gn:BSU14470" /db_xref="EnsemblGenomes-Tr:CAB13320" /db_xref="GOA:P39763" /db_xref="InterPro:IPR004753" /db_xref="SubtiList:BG10987" /db_xref="UniProtKB/Swiss-Prot:P39763" /translation="MFQSTEIGIDLGTANILVYSKNKGIILNEPSVVAVDTTTKAVLA IGADAKNMIGKTPGKIVAVRPMKDGVIADYDMTTDLLKHIMKKAAKSIGMSFRKPNVV VCTPSGSTAVERRAISDAVKNCGAKNVHLIEEPVAAAIGADLPVDEPVANVVVDIGGG TTEVAIISFGGVVSCHSIRIGGDQLDEDIVSFVRKKYNLLIGERTAEQVKMEIGHALI EHIPEAMEIRGRDLVTGLPKTIMLQSNEIQDAMRESLLHILEAIRATLEDCPPELSGD IVDRGVILTGGGALLNGIKEWLTEEIVVPVHVAQNPLESVAIGTGRSLEVIDKLQKAI K*" /label="mreBH CDS" gene complement(1428902..1429909) /gene="mreBH" /locus_tag="BSU_14470" /old_locus_tag="BSU14470" /label="mreBH gene" upshifts complement(1429955) /Source="Nicolas_upshifts" /id="U1193" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=1772 /SigmaFactorBS="ttacaaaaacatttctttaccgacgcacaCCCCCAAAAatcg cagtatttcTGAGAAACTttaaatgtagaatcatattaaattaggatagagattgggt g" /listShort="mreBH, S524, ykpC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1429956..1429964) /Source="Nicolas_upshift_promotors" /id="U1193" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=1772 /SigmaFactorBS="ttacaaaaacatttctttaccgacgcacaCCCCCAAAAatcg cagtatttcTGAGAAACTttaaatgtagaatcatattaaattaggatagagattgggt g" /listShort="mreBH, S524, ykpC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1429978..1429986) /Source="Nicolas_upshift_promotors" /id="U1193" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=1772 /SigmaFactorBS="ttacaaaaacatttctttaccgacgcacaCCCCCAAAAatcg cagtatttcTGAGAAACTttaaatgtagaatcatattaaattaggatagagattgggt g" /listShort="mreBH, S524, ykpC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1430096..1430105 /Source="Nicolas_upshift_promotors" /id="U1194" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp="0.88011988011988" /psig="0.88011988011988" /xcortree=1803 /SigmaFactorBS="ttttatggaaaaaatatcttgtaattcttatagaaagcgGGA AACTTTTtcaaagtttcatTCGTCTACGATATATTgaggtacatccttaaaacattac a" /listShort="S525, abh, S527" /listLong="kinC, ykqA, ktrC" /label="promotor_-35" upshifts 1430117 /Source="Nicolas_upshifts" /id="U1194" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp="0.88011988011988" /psig="0.88011988011988" /xcortree=1803 /SigmaFactorBS="ttttatggaaaaaatatcttgtaattcttatagaaagcgGGA AACTTTTtcaaagtttcatTCGTCTACGATATATTgaggtacatccttaaaacattac a" /listShort="S525, abh, S527" /listLong="kinC, ykqA, ktrC" /label="upshifts" promotor_-10 1430118..1430133 /Source="Nicolas_upshift_promotors" /id="U1194" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp="0.88011988011988" /psig="0.88011988011988" /xcortree=1803 /SigmaFactorBS="ttttatggaaaaaatatcttgtaattcttatagaaagcgGGA AACTTTTtcaaagtttcatTCGTCTACGATATATTgaggtacatccttaaaacattac a" /listShort="S525, abh, S527" /listLong="kinC, ykqA, ktrC" /label="promotor_-10" S_feature 1430120..1430192 /Source="Nicolas_S_feature" /locus_tag="new_1517792_1517864" /HighExp="Lbexp, dia5, LBGexp, dia0, Lbtran, Mt0, Oxctl, Paraq, M0t45, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.88" /TUlongSig="NA" /TUlongPSig="NA" /label="S525" CDS 1430193..1430471 /gene="abhA" /locus_tag="BSU_14480" /old_locus_tag="BSU14480" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16159768, 17720793, 19767430, 20817675, 20844865" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16159768, 17720793, 19767430, 20817675, 20844865; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator" /protein_id="NP_389331.1" /db_xref="EnsemblGenomes-Gn:BSU14480" /db_xref="EnsemblGenomes-Tr:CAB13321" /db_xref="GOA:P39758" /db_xref="InterPro:IPR007159" /db_xref="PDB:2FY9" /db_xref="PDB:2RO3" /db_xref="SubtiList:BG10988" /db_xref="UniProtKB/Swiss-Prot:P39758" /translation="MKSIGVVRKVDELGRIVMPIELRRALDIAIKDSIEFFVDGDKII LKKYKPHGVCLMTGEITSENKEYGNGKITLSPEGAQLLLEEIQAALKE*" /label="abhA CDS" gene 1430193..1430471 /gene="abhA" /locus_tag="BSU_14480" /old_locus_tag="BSU14480" /label="abhA gene" downshifts 1430469 /Source="Nicolas_upshifts" /id="D809" /incds=0 /nref=61 /ntot=238 /MaxReadThrough="4.68201" /MaxDrop="5.62457" /score="7.91393519" /energy="-11" /TU="U1194" /idTUdmin="U1194" /TUdmin="-135" /isTUend="FALSE" /label="downshifts" S_feature complement(1430503..1432132) /Source="Nicolas_S_feature" /locus_tag="new_1518175_1519804_c" /HighExp="S6, S8, S5, LoTm, S4, S7, S3, C30, T5.0H, BT" /AntisenseName="kinC" /AntisenseCor="-0.76370141168998495" /AntisenseRegPval="-51.9" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S526" S_feature 1430514..1430618 /Source="Nicolas_S_feature" /locus_tag="new_1518186_1518290" /HighExp="Oxctl, Lbexp, LBGexp, H2O2, dia0, Paraq, G180, G150, G135, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.88" /TUlongSig="NA" /TUlongPSig="NA" /label="S527" downshifts complement(1430526) /Source="Nicolas_upshifts" /id="D810" /incds=0 /nref=1 /ntot=22 /MaxReadThrough="0.833919999999999" /MaxDrop="3.11258" /score="8.02057524" /energy="-11" /TU="NA" /idTUdmin="U1196" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1430600..1430607 /Source="Nicolas_upshift_promotors" /id="U1195" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2153 /SigmaFactorBS="atatttggtaatgaatgatttgggatactttacatattttAC TCAATTatttgtcgaagAATGGTACAATAAGTAGAGAaacacaagcggcaggtggtca t" /listShort="kinC, ykqA, ktrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1430619..1430638 /Source="Nicolas_upshift_promotors" /id="U1195" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2153 /SigmaFactorBS="atatttggtaatgaatgatttgggatactttacatattttAC TCAATTatttgtcgaagAATGGTACAATAAGTAGAGAaacacaagcggcaggtggtca t" /listShort="kinC, ykqA, ktrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1430620 /Source="Nicolas_upshifts" /id="U1195" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2153 /SigmaFactorBS="atatttggtaatgaatgatttgggatactttacatattttAC TCAATTatttgtcgaagAATGGTACAATAAGTAGAGAaacacaagcggcaggtggtca t" /listShort="kinC, ykqA, ktrC" /GFF_Attribute="listLong" /label="upshifts" CDS 1430661..1431947 /gene="kinC" /locus_tag="BSU_14490" /old_locus_tag="BSU14490" /EC_number="2.7.13.3" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11069677, 11673427, 7836330, 20971918, 25701730, 26152584, 23569226, 26297017" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11069677, 11673427, 7836330, 20971918, 25701730, 26152584, 23569226, 26297017; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="two-component sensor potassium-responsive histidine kinase regulating cannibalism and biofilm formation" /protein_id="NP_389332.1" /db_xref="EnsemblGenomes-Gn:BSU14490" /db_xref="EnsemblGenomes-Tr:CAB13322" /db_xref="GOA:P39764" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR000700" /db_xref="InterPro:IPR001610" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR013767" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10989" /db_xref="UniProtKB/Swiss-Prot:P39764" /translation="MRKYQARIISIILAMIFIMFWDYLFYFIGKNPINWPVDIVYTAV TLVSVWMLAYYIDEKQQLVKKMKDNEWKYKQLSEEKNRIMDNLQEIVFQTNAKGEITY LNQAWASITGFSISECMGTMYNDYFIKEKHVADHINTQIQNKASSGMFTAKYVTKNGT IFWGEVHYKLYYDRDDQFTGSLGTMSDITERKEAEDELIEINERLARESQKLSITSEL AAGIAHEVRNPLTSVSGFLQIMKTQYPDRKDYFDIIFSEIKRIDLVLSELLLLAKPQA ITFKTHQLNEILKQVTTLLDTNAILSNIVIEKNFKETDGCMINGDENQLKQVFINIIK NGIEAMPKGGVVTISTAKTASHAVISVKDEGNGMPQEKLKQIGKPFYSTKEKGTGLGL PICLRILKEHDGELKIESEAGKGSVFQVVLPLKSDS*" /label="kinC CDS" gene 1430661..1431947 /gene="kinC" /locus_tag="BSU_14490" /old_locus_tag="BSU14490" /label="kinC gene" CDS 1431963..1432796 /gene="ykqA" /locus_tag="BSU_14500" /old_locus_tag="BSU14500" /EC_number="2.3.2.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 28537416; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative gamma-glutamylcyclotransferase (bacillithiol degradation)" /protein_id="NP_389333.1" /db_xref="EnsemblGenomes-Gn:BSU14500" /db_xref="EnsemblGenomes-Tr:CAB13323" /db_xref="GOA:P39759" /db_xref="InterPro:IPR009288" /db_xref="InterPro:IPR013024" /db_xref="InterPro:IPR036568" /db_xref="PDB:2QIK" /db_xref="SubtiList:BG10990" /db_xref="UniProtKB/Swiss-Prot:P39759" /translation="MNSLLFVYGTLRKHEKNHHLLAQSACINEQARTKGSLFAAKEGP TVVFNDEDEGYIYGEVYEADELCIHKLDQFFQGYHKQTVFVETDVGIKIALIYFMNKD GCAGFTKISSGDWKEHQMISKSKNPIYYFAYGSCMDNARFQKAGVDHYFQDPVGRAVL KGYTTRFTLKREDGSRADMLEDGGTTEGVLYRIPYSALSYLYKREGVESLTYRPAFVD VEAGGRHYKDCLTFLVLQKEAEIAPPQHYQIEIERGAELYLSPEFTEKLKRHMNSLPK G*" /label="ykqA CDS" gene 1431963..1432796 /gene="ykqA" /locus_tag="BSU_14500" /old_locus_tag="BSU14500" /label="ykqA gene" promotor_-10 complement(1432129..1432147) /Source="Nicolas_upshift_promotors" /id="U1196" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1080 /SigmaFactorBS="tgtttatgatatccttgaaaaaattgatcgagcttaTGTATA cacaattcatctgctTCATATACTTCGCCATATAtatagccttcatcttcatcattga a" /listShort="S526" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1432144) /Source="Nicolas_upshifts" /id="U1196" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1080 /SigmaFactorBS="tgtttatgatatccttgaaaaaattgatcgagcttaTGTATA cacaattcatctgctTCATATACTTCGCCATATAtatagccttcatcttcatcattga a" /listShort="S526" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1432163..1432168) /Source="Nicolas_upshift_promotors" /id="U1196" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1080 /SigmaFactorBS="tgtttatgatatccttgaaaaaattgatcgagcttaTGTATA cacaattcatctgctTCATATACTTCGCCATATAtatagccttcatcttcatcattga a" /listShort="S526" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1432859..1433524 /gene="ktrC" /locus_tag="BSU_14510" /old_locus_tag="BSU14510" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12562800, 15096624, 22720735, 23963175, 28420751" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562800, 15096624, 22720735, 23963175, 28420751; Product type t : transporter" /codon_start=1 /transl_table=11 /product="potassium uptake protein" /protein_id="NP_389334.1" /db_xref="EnsemblGenomes-Gn:BSU14510" /db_xref="EnsemblGenomes-Tr:CAB13324" /db_xref="GOA:P39760" /db_xref="InterPro:IPR003148" /db_xref="InterPro:IPR006037" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR036721" /db_xref="SubtiList:BG10991" /db_xref="UniProtKB/Swiss-Prot:P39760" /translation="MKKEFAVIGLGRFGGSICKALSEEGVEVMAMDIDEDKVNEYAKI ASHAVIGDSTDESVLKNLGLRNFDHVIVAIGENIQASILTTLILKELGVHTITVKAQN DYHEKVLSKIGADHIVHPERDMAKRIAHNIVSNNVLDYLELSEEHSLVEIVANSRLAG NTLLDLDIRAKYGINIVAIKRGKEVIVSPLATEVIHQEDILIVIGSVTDISRFEKRVL HTK*" /label="ktrC CDS" gene 1432859..1433524 /gene="ktrC" /locus_tag="BSU_14510" /old_locus_tag="BSU14510" /label="ktrC gene" downshifts 1433508 /Source="Nicolas_upshifts" /id="D811" /incds=0 /nref=191 /ntot=256 /MaxReadThrough="3.15176" /MaxDrop="5.50828" /score="4.60161255" /energy="-8.2" /TU="U1195" /idTUdmin="U1195" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" promotor_-35 1433615..1433621 /Source="Nicolas_upshift_promotors" /id="U1197" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.305694305694306" /psig="0.861138861138861" /xcortree=2383 /SigmaFactorBS="aactgagcgtcaatttcttaaaatttcATTGACTaagcacag gcgttcCGATAGCATATTGTACCATAtaataaaaaaaggaggggcctatttgaataaa g" /listShort="adeC" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1433636..1433655) /Source="Nicolas_upshift_promotors" /id="U1198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.584415584415584" /psig="0.985014985014985" /xcortree=1841 /SigmaFactorBS="ttcagcctattgactagcgcttctttattcaaataggcccct cctttttttattaTATGGTACAATATGCTATCGgaacgcctgtgcttagtcaatgaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 1433636..1433655 /Source="Nicolas_upshift_promotors" /id="U1197" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.305694305694306" /psig="0.861138861138861" /xcortree=2383 /SigmaFactorBS="aactgagcgtcaatttcttaaaatttcATTGACTaagcacag gcgttcCGATAGCATATTGTACCATAtaataaaaaaaggaggggcctatttgaataaa g" /listShort="adeC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1433648 /Source="Nicolas_upshifts" /id="U1197" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.305694305694306" /psig="0.861138861138861" /xcortree=2383 /SigmaFactorBS="aactgagcgtcaatttcttaaaatttcATTGACTaagcacag gcgttcCGATAGCATATTGTACCATAtaataaaaaaaggaggggcctatttgaataaa g" /listShort="adeC" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1433650) /Source="Nicolas_upshifts" /id="U1198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.584415584415584" /psig="0.985014985014985" /xcortree=1841 /SigmaFactorBS="ttcagcctattgactagcgcttctttattcaaataggcccct cctttttttattaTATGGTACAATATGCTATCGgaacgcctgtgcttagtcaatgaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1433679..1435412 /gene="adeC" /locus_tag="BSU_14520" /old_locus_tag="BSU14520" /EC_number="3.5.4.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:6408059, 8550522, 17183219" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6408059, 8550522, 17183219; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="adenine deaminase" /protein_id="NP_389335.2" /db_xref="EnsemblGenomes-Gn:BSU14520" /db_xref="EnsemblGenomes-Tr:CAB13325" /db_xref="GOA:P39761" /db_xref="InterPro:IPR006679" /db_xref="InterPro:IPR006680" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR026912" /db_xref="InterPro:IPR032466" /db_xref="SubtiList:BG11044" /db_xref="UniProtKB/Swiss-Prot:P39761" /translation="MNKEALVNRLNASAKRQKADIVIKNGKIMDVYNQEWIYEDIAIT DGVIVGLGEYEGENIIDAEGQMIVPGFIDGHVHIESSMVTPIEFAKAVLPHGVTTVVT DPHEIANVSGEKGIEFMLEQARHTPLNIHFMLPSSVPAASFERSGAILKAADLKPFYE EEEVLGLAEVMDYVSVQQAEKDMVQKLLDARVAGKRIDGHLAGLSTDLINIYRTAFVL NDHEVTSKEEALDRIRRGMYVMMREGSVAKNTLNVLPAVNEKNARRFFFCTDDKHVDD LLSEGSVNHQVKMAIQAGLNPFLAYQLGSLNAAECYGLDTKGAIAPGFDADLLFVSDL ENVTVTMTMVKGQTVAEDSKAVYQDHASTAAPDQALLDSVKLAAPLNKQDFHMPIDSE QQINVIQIIPNQLETRLVQVPAPVAREFEPDTELDLLKIAVVERHKGLKETGLGVVKG FGFKSGAIATTISHDSHNIIAVGTNDEDIAAAVNKLQEIGGGLTIIKNGEELHSVPLP IAGLLSDQSAEQVNQSLLTLHDKLSLIGFTGGFNPFLTLSFLALPVIPDIKMTTTGLF DVKSFQHISLQ*" /label="adeC CDS" gene 1433679..1435412 /gene="adeC" /locus_tag="BSU_14520" /old_locus_tag="BSU14520" /label="adeC gene" S_feature complement(1434807..1435411) /Source="Nicolas_S_feature" /locus_tag="new_1522479_1523083_c" /HighExp="Etha, C30, C90, dia15, LBGexp, Cold, dia5, S8, G180, S7" /AntisenseName="adeC" /AntisenseCor="-9.8927927273806792E-3" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S528" downshifts 1435401 /Source="Nicolas_upshifts" /id="D812" /incds=0 /nref=51 /ntot=223 /MaxReadThrough="1.93923" /MaxDrop="6.63088" /score="44.3452043" /energy="-19.5" /TU="NA" /idTUdmin="U1197" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" CDS complement(1435446..1437113) /gene="rnjA" /locus_tag="BSU_14530" /old_locus_tag="BSU14530" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12682299, 15831787, 17005971, 17229210, 17512403, 18713320, 19850915, 21893285, 21893286, 20025672, 22720735, 23504012, 24187087" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15831787, 17005971, 17229210, 17512403, 18713320, 19850915, 21893285, 21893286, 20025672, 22720735, 23504012, 24187087; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease J1" /protein_id="NP_389336.1" /db_xref="EnsemblGenomes-Gn:BSU14530" /db_xref="EnsemblGenomes-Tr:CAB13326" /db_xref="GOA:Q45493" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR001587" /db_xref="InterPro:IPR004613" /db_xref="InterPro:IPR011108" /db_xref="InterPro:IPR030854" /db_xref="InterPro:IPR036866" /db_xref="PDB:3ZQ4" /db_xref="SubtiList:BG11813" /db_xref="UniProtKB/Swiss-Prot:Q45493" /translation="MKFVKNDQTAVFALGGLGEIGKNTYAVQFQDEIVLIDAGIKFPE DELLGIDYVIPDYTYLVKNEDKIKGLFITHGHEDHIGGIPYLLRQVNIPVYGGKLAIG LLRNKLEEHGLLRQTKLNIIGEDDIVKFRKTAVSFFRTTHSIPDSYGIVVKTPPGNIV HTGDFKFDFTPVGEPANLTKMAEIGKEGVLCLLSDSTNSENPEFTMSERRVGESIHDI FRKVDGRIIFATFASNIHRLQQVIEAAVQNGRKVAVFGRSMESAIEIGQTLGYINCPK NTFIEHNEINRMPANKVTILCTGSQGEPMAALSRIANGTHRQISINPGDTVVFSSSPI PGNTISVSRTINQLYRAGAEVIHGPLNDIHTSGHGGQEEQKLMLRLIKPKFFMPIHGE YRMQKMHVKLATDCGIPEENCFIMDNGEVLALKGDEASVAGKIPSGSVYIDGSGIGDI GNIVLRDRRILSEEGLVIVVVSIDMDDFKISAGPDLISRGFVYMRESGDLINDAQELI SNHLQKVMERKTTQWSEIKNEITDTLAPFLYEKTKRRPMILPIIMEV*" /label="rnjA CDS" gene complement(1435446..1437113) /gene="rnjA" /locus_tag="BSU_14530" /old_locus_tag="BSU14530" /label="rnjA gene" downshifts complement(1435456) /Source="Nicolas_upshifts" /id="D813" /incds=0 /nref=149 /ntot=269 /MaxReadThrough="4.3738" /MaxDrop="8.12983" /score="37.2074215" /energy="-19.5" /TU="U1199" /idTUdmin="U1200" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(1437119..1437328) /gene="rnpZA" /locus_tag="BSU_14540" /old_locus_tag="BSU14540" /function="9.2: DNA-dependent RNA polymerase" /experiment="publication(s) with functional evidences, PMID:18289874, 24187087" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18289874, 24187087; Product type f: factor" /codon_start=1 /transl_table=11 /product="omega 1 subunit of RNA polymerase" /protein_id="NP_389337.1" /db_xref="EnsemblGenomes-Gn:BSU14540" /db_xref="EnsemblGenomes-Tr:CAB13327" /db_xref="InterPro:IPR009907" /db_xref="SubtiList:BG13335" /db_xref="UniProtKB/Swiss-Prot:O31718" /translation="MIYKVFYQEKADEVPVREKTDSLYIEGVSERDVRTKLKEKKFNI EFITPVDGAFLEYEQQSENFKVLEL*" /label="rnpZA CDS" gene complement(1437119..1437328) /gene="rnpZA" /locus_tag="BSU_14540" /old_locus_tag="BSU14540" /label="rnpZA gene" promotor_-10 complement(1437365..1437384) /Source="Nicolas_upshift_promotors" /id="U1199" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.952047952047952" /psig="0.999000999001" /xcortree=2285 /SigmaFactorBS="acaagggatctttcactttttgagagatccttattttgctca aggCTTTccttatattccgttTTCGAATATAATAGAATGAGcgagtctaacatacggc a" /listShort="ykzG, rnjA, S528" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1437387) /Source="Nicolas_upshifts" /id="U1199" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.952047952047952" /psig="0.999000999001" /xcortree=2285 /SigmaFactorBS="acaagggatctttcactttttgagagatccttattttgctca aggCTTTccttatattccgttTTCGAATATAATAGAATGAGcgagtctaacatacggc a" /listShort="ykzG, rnjA, S528" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1437389..1437566) /Source="Nicolas_S_feature" /locus_tag="new_1525061_1525238_c" /HighExp="S5, S8, S7, S6, S4, ferm, nit, T5.0H, HiTm, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.97062099999999996" /TUshortSig="SigGF" /TUshortPSig="0.828" /TUlongSig="NA" /TUlongPSig="NA" /label="S529" promotor_-35 complement(1437399..1437402) /Source="Nicolas_upshift_promotors" /id="U1199" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.952047952047952" /psig="0.999000999001" /xcortree=2285 /SigmaFactorBS="acaagggatctttcactttttgagagatccttattttgctca aggCTTTccttatattccgttTTCGAATATAATAGAATGAGcgagtctaacatacggc a" /listShort="ykzG, rnjA, S528" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1437567) /Source="Nicolas_upshifts" /id="U1200" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.828171828171828" /psig="0.828171828171828" /xcortree=816 /SigmaFactorBS="aatcatattaaattccattaataaccaCGAAAAGtcttcctc aatctCCGTATACTATTtgtataaaagaactctgggacaaatttttcattaaaggagg g" /listShort="S529, ykzG, rnjA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1437569..1437580) /Source="Nicolas_upshift_promotors" /id="U1200" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.828171828171828" /psig="0.828171828171828" /xcortree=816 /SigmaFactorBS="aatcatattaaattccattaataaccaCGAAAAGtcttcctc aatctCCGTATACTATTtgtataaaagaactctgggacaaatttttcattaaaggagg g" /listShort="S529, ykzG, rnjA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1437594..1437600) /Source="Nicolas_upshift_promotors" /id="U1200" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.828171828171828" /psig="0.828171828171828" /xcortree=816 /SigmaFactorBS="aatcatattaaattccattaataaccaCGAAAAGtcttcctc aatctCCGTATACTATTtgtataaaagaactctgggacaaatttttcattaaaggagg g" /listShort="S529, ykzG, rnjA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1437639..1437646 /Source="Nicolas_upshift_promotors" /id="U1201" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.717282717282717" /psig="0.999000999001" /xcortree=1936 /SigmaFactorBS="tttaatatgatttttgaacgaaaTTGTTTGCtgaatgacaat ctTTTTGTATGATGAGGGTGGGaattgcagaccaagacgataaaggggaagttgcgat g" /listShort="ykrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1437660..1437679 /Source="Nicolas_upshift_promotors" /id="U1201" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.717282717282717" /psig="0.999000999001" /xcortree=1936 /SigmaFactorBS="tttaatatgatttttgaacgaaaTTGTTTGCtgaatgacaat ctTTTTGTATGATGAGGGTGGGaattgcagaccaagacgataaaggggaagttgcgat g" /listShort="ykrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1437676 /Source="Nicolas_upshifts" /id="U1201" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.717282717282717" /psig="0.999000999001" /xcortree=1936 /SigmaFactorBS="tttaatatgatttttgaacgaaaTTGTTTGCtgaatgacaat ctTTTTGTATGATGAGGGTGGGaattgcagaccaagacgataaaggggaagttgcgat g" /listShort="ykrA" /GFF_Attribute="listLong" /label="upshifts" CDS 1437714..1438487 /gene="ykrA" /locus_tag="BSU_14550" /old_locus_tag="BSU14550" /EC_number="3.1.3.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_389338.1" /db_xref="EnsemblGenomes-Gn:BSU14550" /db_xref="EnsemblGenomes-Tr:CAB13328" /db_xref="GOA:Q45494" /db_xref="InterPro:IPR000150" /db_xref="InterPro:IPR006379" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG11814" /db_xref="UniProtKB/Swiss-Prot:Q45494" /translation="MDSKLIFFDIDGTIYDHDKNIPESTRKTVAELQRQGHHVFIASG RSPFLVKPILEELGIHSFISYNGQFVVFENQVIYKNPLPENAIRRLLKQADEGKHPVV FMAEDTMKATVADHPHVLEGIGSLKTDYPETDDLFYEGKEIFQLLLFCQDEEEKAYAA FPEFDLVRWHELSTDVLPHGGSKAEGIKKVIERLPFDIGDTYAFGDGLNDLQMIEYVG TGVAMGNAVPELKEIADFVTKPVDEDGIAYAVKELGLLK*" /label="ykrA CDS" gene 1437714..1438487 /gene="ykrA" /locus_tag="BSU_14550" /old_locus_tag="BSU14550" /label="ykrA gene" downshifts 1438458 /Source="Nicolas_upshifts" /id="D814" /incds=0 /nref=184 /ntot=249 /MaxReadThrough="2.83896" /MaxDrop="6.20802" /score="28.5519453" /energy="-15.4" /TU="U1201" /idTUdmin="U1201" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(1438523..1439077) /gene="defB" /locus_tag="BSU_14560" /old_locus_tag="BSU14560" /EC_number="3.5.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11429456, 16207374, 23944997, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11429456, 16207374, 23944997, 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-formyl-cysteine deformylase (promiscuous)" /protein_id="NP_389339.1" /db_xref="EnsemblGenomes-Gn:BSU14560" /db_xref="EnsemblGenomes-Tr:CAB13329" /db_xref="GOA:Q45495" /db_xref="InterPro:IPR023635" /db_xref="InterPro:IPR036821" /db_xref="SubtiList:BG11815" /db_xref="UniProtKB/Swiss-Prot:Q45495" /translation="MITMENIVRDGHPALRETAEPVELPPTDAEKQQLADMIEFVKNS QNPELAEKYKLRPGVGLAAPQINIKKRMIAVHAEDASGKLYSYALFNPKIVSHSVEKS YLTSGEGCLSVDEAIPGYVPRYARIRVKGTTLEGENIDIRLKGFPAIVFQHEIDHLNG VMFYDHIDKENPFKEPENAIAIER*" /label="defB CDS" gene complement(1438523..1439077) /gene="defB" /locus_tag="BSU_14560" /old_locus_tag="BSU14560" /label="defB gene" downshifts complement(1438534) /Source="Nicolas_upshifts" /id="D815" /incds=0 /nref=208 /ntot=265 /MaxReadThrough="1.87469" /MaxDrop="5.89844" /score="28.3817715" /energy="-15.4" /TU="NA" /idTUdmin="U1202" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1439099..1439118) /Source="Nicolas_upshift_promotors" /id="U1202" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.686313686313686" /psig="0.995004995004995" /xcortree=1852 /SigmaFactorBS="gaccagccatatacggctggtcattcgttTCGTTGCAccttt gtgaagaaaTCCGATATAATTTACATATTaagctttaggagtgaagtttcttgattac t" /listShort="defB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1439109) /Source="Nicolas_upshifts" /id="U1202" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.686313686313686" /psig="0.995004995004995" /xcortree=1852 /SigmaFactorBS="gaccagccatatacggctggtcattcgttTCGTTGCAccttt gtgaagaaaTCCGATATAATTTACATATTaagctttaggagtgaagtttcttgattac t" /listShort="defB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1439133..1439140) /Source="Nicolas_upshift_promotors" /id="U1202" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.686313686313686" /psig="0.995004995004995" /xcortree=1852 /SigmaFactorBS="gaccagccatatacggctggtcattcgttTCGTTGCAccttt gtgaagaaaTCCGATATAATTTACATATTaagctttaggagtgaagtttcttgattac t" /listShort="defB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1439162 /Source="Nicolas_upshifts" /id="D816" /incds=0 /nref=1 /ntot=11 /MaxReadThrough="0.95601" /MaxDrop="4.18336" /score="0.455865843" /energy="-17.1" /TU="NA" /idTUdmin="U1201" /TUdmin=682 /isTUend="FALSE" /label="downshifts" downshifts complement(1439186) /Source="Nicolas_upshifts" /id="D817" /incds=0 /nref=44 /ntot=63 /MaxReadThrough="2.11854" /MaxDrop="8.20445" /score="-8.94821426" /energy="-15.3" /TU="NA" /idTUdmin="U1204" /TUdmin="-14" /isTUend="TRUE" /label="downshifts" CDS complement(1439187..1439345) /gene="ykzV" /locus_tag="BSU_14569" /old_locus_tag="BSU14569" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20156992, 21670523; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative type I toxin (toxin I motif)" /protein_id="YP_003097725.1" /db_xref="EnsemblGenomes-Gn:BSU14569" /db_xref="EnsemblGenomes-Tr:CAX52616" /db_xref="GOA:C0H409" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/Swiss-Prot:C0H409" /translation="MYGYGYGGGCCSYGGYGYGGCGYGYGRTFALIVVLFILLIIVGA AYLGGGCC*" /label="ykzV CDS" gene complement(1439187..1439345) /gene="ykzV" /locus_tag="BSU_14569" /old_locus_tag="BSU14569" /label="ykzV gene" CDS complement(1439252..1439395) /locus_tag="BSU_14568" /old_locus_tag="BSU14568" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative antitoxin" /protein_id="YP_009513955.1" /db_xref="EnsemblGenomes-Gn:BSU14568" /db_xref="EnsemblGenomes-Tr:CCQ48596" /db_xref="UniProtKB/TrEMBL:L8E9Z2" /translation="MPTYKGSGVIKRGGYVICMDMVTAEAAAVMVVTDMVAADMATAA PLR*" /label="putative antitoxin CDS" gene complement(1439252..1439395) /locus_tag="BSU_14568" /old_locus_tag="BSU14568" /label="gene" promotor_-35 1439341..1439345 /Source="Nicolas_upshift_promotors" /id="U1203" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=704 /SigmaFactorBS="tccgccgtaaccatatccaTACATattacataaCCTCCTCTT TTAATTacgccagagcctttataagtaggcatagcgtctaatataacctatgtaaaaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1439346..1439414) /Source="Nicolas_S_feature" /locus_tag="new_1527018_1527086_c" /HighExp="S8, S7, BT, S6, G/S, B36, Pyr, S5, B60, SMMPr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S530" promotor_-10 1439355..1439369 /Source="Nicolas_upshift_promotors" /id="U1203" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=704 /SigmaFactorBS="tccgccgtaaccatatccaTACATattacataaCCTCCTCTT TTAATTacgccagagcctttataagtaggcatagcgtctaatataacctatgtaaaaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1439382 /Source="Nicolas_upshifts" /id="U1203" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=704 /SigmaFactorBS="tccgccgtaaccatatccaTACATattacataaCCTCCTCTT TTAATTacgccagagcctttataagtaggcatagcgtctaatataacctatgtaaaaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1439398..1439417) /Source="Nicolas_upshift_promotors" /id="U1204" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1277 /SigmaFactorBS="aaatgcaatactgaaattaaatcaaaaaagtgaaaaatcagg acagatGACCATACAActtttttgttttTACATAGGTTATATTAGACGctatgcctac t" /listShort="S530, ykzV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1439427) /Source="Nicolas_upshifts" /id="U1204" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1277 /SigmaFactorBS="aaatgcaatactgaaattaaatcaaaaaagtgaaaaatcagg acagatGACCATACAActtttttgttttTACATAGGTTATATTAGACGctatgcctac t" /listShort="S530, ykzV" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1439430..1439439) /Source="Nicolas_upshift_promotors" /id="U1204" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1277 /SigmaFactorBS="aaatgcaatactgaaattaaatcaaaaaagtgaaaaatcagg acagatGACCATACAActtttttgttttTACATAGGTTATATTAGACGctatgcctac t" /listShort="S530, ykzV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1439501..1439508 /Source="Nicolas_upshift_promotors" /id="U1205" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.74025974025974" /psig=1 /xcortree=2147 /SigmaFactorBS="atttaatttcagtattgcatttatacagcacggctATTGCCA AatgtccccatggaTTCTATAGTAGAAATTGTCAagattgggggatttaacgtgaaag a" /listShort="ykyA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1439522..1439541 /Source="Nicolas_upshift_promotors" /id="U1205" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.74025974025974" /psig=1 /xcortree=2147 /SigmaFactorBS="atttaatttcagtattgcatttatacagcacggctATTGCCA AatgtccccatggaTTCTATAGTAGAAATTGTCAagattgggggatttaacgtgaaag a" /listShort="ykyA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1439526 /Source="Nicolas_upshifts" /id="U1205" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.74025974025974" /psig=1 /xcortree=2147 /SigmaFactorBS="atttaatttcagtattgcatttatacagcacggctATTGCCA AatgtccccatggaTTCTATAGTAGAAATTGTCAagattgggggatttaacgtgaaag a" /listShort="ykyA" /GFF_Attribute="listLong" /label="upshifts" CDS 1439559..1440230 /gene="ykyA" /locus_tag="BSU_14570" /old_locus_tag="BSU14570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16684363, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_389340.2" /db_xref="EnsemblGenomes-Gn:BSU14570" /db_xref="EnsemblGenomes-Tr:CAB13330" /db_xref="GOA:P21884" /db_xref="InterPro:IPR019454" /db_xref="InterPro:IPR036785" /db_xref="SubtiList:BG10206" /db_xref="UniProtKB/Swiss-Prot:P21884" /translation="MKDAIKRRPGIKIGAFCAMALILTGCMGQDPVDSLHHSLEKAAE SEKPFQEEQNTLKELEAKENQLYDSVMKLNMDDYKKIVALSNKALENVSKREEHLKLE NDSMKKSETEFEEAKTSAEHIKEKDIKEKADAAANHMEKRYTSYGTMYKEYKKALELN KKLYMQLKDKDLTRDDLDQQIDKVNASYEKILKYSGEFNEQTEKYNKAREDLYDAAGY RVKKS*" /label="ykyA CDS" gene 1439559..1440230 /gene="ykyA" /locus_tag="BSU_14570" /old_locus_tag="BSU14570" /label="ykyA gene" promotor_-35 1439898..1439907 /Source="Nicolas_upshift_promotors" /id="U1206" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.613386613386613" /psig="0.613386613386613" /xcortree=595 /SigmaFactorBS="gcatgaaaaaatcggaaacagaatttGAGGAAGCAAaaacgt cagcggAACATATTAAGGAAAAAGAcataaaagaaaaggccgatgccgcagcaaacca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1439920..1439938 /Source="Nicolas_upshift_promotors" /id="U1206" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.613386613386613" /psig="0.613386613386613" /xcortree=595 /SigmaFactorBS="gcatgaaaaaatcggaaacagaatttGAGGAAGCAAaaacgt cagcggAACATATTAAGGAAAAAGAcataaaagaaaaggccgatgccgcagcaaacca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1439932 /Source="Nicolas_upshifts" /id="U1206" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.613386613386613" /psig="0.613386613386613" /xcortree=595 /SigmaFactorBS="gcatgaaaaaatcggaaacagaatttGAGGAAGCAAaaacgt cagcggAACATATTAAGGAAAAAGAcataaaagaaaaggccgatgccgcagcaaacca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1440177 /Source="Nicolas_upshifts" /id="D818" /incds=0 /nref=96 /ntot=244 /MaxReadThrough="3.9299" /MaxDrop="6.03956" /score="20.6110953" /energy="-9.9" /TU="U1205" /idTUdmin="U1206" /TUdmin=3 /isTUend="TRUE" /label="downshifts" promotor_-35 1440405..1440410 /Source="Nicolas_upshift_promotors" /id="U1207" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.524475524475524" /psig=1 /xcortree=2692 /SigmaFactorBS="aagcgaatacatttattgaaaatcagcgatgaaaacgATTGA CggttcttctttatttgGTGTAAACTAATCCATGTTAagcggtgttgtattagttttt t" /listShort="S531, pdhA, pdhB, S532, pdhC, pdhD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1440427..1440446 /Source="Nicolas_upshift_promotors" /id="U1207" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.524475524475524" /psig=1 /xcortree=2692 /SigmaFactorBS="aagcgaatacatttattgaaaatcagcgatgaaaacgATTGA CggttcttctttatttgGTGTAAACTAATCCATGTTAagcggtgttgtattagttttt t" /listShort="S531, pdhA, pdhB, S532, pdhC, pdhD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1440428..1440653 /Source="Nicolas_S_feature" /locus_tag="new_1528100_1528325" /HighExp="nit, MG-0.1, Diami, MG-0.2, ferm, dia5, Lbexp, dia0, Paraq, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S531" upshifts 1440428 /Source="Nicolas_upshifts" /id="U1207" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.524475524475524" /psig=1 /xcortree=2692 /SigmaFactorBS="aagcgaatacatttattgaaaatcagcgatgaaaacgATTGA CggttcttctttatttgGTGTAAACTAATCCATGTTAagcggtgttgtattagttttt t" /listShort="S531, pdhA, pdhB, S532, pdhC, pdhD" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(1440432..1440451) /Source="Nicolas_upshift_promotors" /id="U1208" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.363636363636364" /psig="0.616383616383616" /xcortree=293 /SigmaFactorBS="tagttacactctgctttgaactgtattatttcgaagttgtaa aaaactaatacaacaCCGCTTAACATGGATTAGTTtacaccaaataaagaagaaccgt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1440448) /Source="Nicolas_upshifts" /id="U1208" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.363636363636364" /psig="0.616383616383616" /xcortree=293 /SigmaFactorBS="tagttacactctgctttgaactgtattatttcgaagttgtaa aaaactaatacaacaCCGCTTAACATGGATTAGTTtacaccaaataaagaagaaccgt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1440552..1440560) /Source="Nicolas_upshift_promotors" /id="U1209" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.891108891108891" /psig="0.891108891108891" /xcortree=349 /SigmaFactorBS="tagacgtgcattccttttatacatacaaacttagggTACCCT AAAgtatcagcagtaaGTCGTATTAtattttagccgatccccagtttgccaaaacctt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1440558) /Source="Nicolas_upshifts" /id="U1209" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.891108891108891" /psig="0.891108891108891" /xcortree=349 /SigmaFactorBS="tagacgtgcattccttttatacatacaaacttagggTACCCT AAAgtatcagcagtaaGTCGTATTAtattttagccgatccccagtttgccaaaacctt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1440574..1440582) /Source="Nicolas_upshift_promotors" /id="U1209" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.891108891108891" /psig="0.891108891108891" /xcortree=349 /SigmaFactorBS="tagacgtgcattccttttatacatacaaacttagggTACCCT AAAgtatcagcagtaaGTCGTATTAtattttagccgatccccagtttgccaaaacctt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1440654..1441769 /gene="pdhA" /locus_tag="BSU_14580" /old_locus_tag="BSU14580" /EC_number="1.2.4.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1729239, 1784816, 4984174, 6409095, 6815422, 9352926, 9588797, 11976308, 12469342" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1729239, 1784816, 4984174, 6409095, 6815422, 9352926, 9588797, 11976308, 12469342; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyruvate dehydrogenase (E1 alpha subunit)" /protein_id="NP_389341.1" /db_xref="EnsemblGenomes-Gn:BSU14580" /db_xref="EnsemblGenomes-Tr:CAB13331" /db_xref="GOA:P21881" /db_xref="InterPro:IPR001017" /db_xref="InterPro:IPR017596" /db_xref="InterPro:IPR029061" /db_xref="SubtiList:BG10207" /db_xref="UniProtKB/Swiss-Prot:P21881" /translation="MAAKTKKAIVDSKKQFDAIKKQFETFQILNEKGEVVNEAAMPDL TDDQLKELMRRMVFTRVLDQRSISLNRQGRLGFYAPTAGQEASQIATHFALEKEDFVL PGYRDVPQLIWHGLPLYQAFLFSRGHFRGNQMPDDVNALSPQIIIGAQYIQTAGVALG LKKRGKKAVAITYTGDGGASQGDFYEGINFAGAYKAPAIFVVQNNRYAISTPVEKQSA AETIAQKAVAAGIVGVQVDGMDPLAVYAATAEARERAINGEGPTLIETLTFRYGPHTM AGDDPTKYRTKEIENEWEQKDPLVRFRAFLENKGLWSEEEEAKVIEDAKEEIKQAIKK ADAEPKQKVTDLMKIMYEKMPHNLEEQFEIYTQKESK*" /label="pdhA CDS" gene 1440654..1441769 /gene="pdhA" /locus_tag="BSU_14580" /old_locus_tag="BSU14580" /label="pdhA gene" CDS 1441773..1442750 /gene="pdhB" /locus_tag="BSU_14590" /old_locus_tag="BSU14590" /EC_number="1.2.4.1" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1784816, 9352926, 9588797, 9891797, 10735853, 11976308" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1784816, 9352926, 9588797, 9891797, 10735853, 11976308; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="pyruvate dehydrogenase (E1 beta subunit)" /protein_id="NP_389342.1" /db_xref="EnsemblGenomes-Gn:BSU14590" /db_xref="EnsemblGenomes-Tr:CAB13332" /db_xref="GOA:P21882" /db_xref="InterPro:IPR005475" /db_xref="InterPro:IPR009014" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR033248" /db_xref="SubtiList:BG10208" /db_xref="UniProtKB/Swiss-Prot:P21882" /translation="MAQMTMIQAITDALRTELKNDENVLVFGEDVGVNGGVFRATEGL QKEFGEDRVFDTPLAESGIGGLALGLGLNGFRPVMEIQFFGFVYEVMDSVSGQMARMR YRSGGRWTSPVTIRSPFGGGVHTPELHADSLEGLVAQQPGIKVVIPSTPYDAKGLLIS AIRDNDPVVFLEHMKLYRSFRQEVPEEEYTIELGKADVKREGTDLSIITYGAMVHESL KAADELEKDGISAEVVDLRTVSPLDIDTIIASVEKTGRAIVVQEAQKQAGIAANVVAE INDRAILSLEAPVLRVAAPDTVFPFSQAESVWLPNHKDVLETARKVLEF*" /label="pdhB CDS" gene 1441773..1442750 /gene="pdhB" /locus_tag="BSU_14590" /old_locus_tag="BSU14590" /label="pdhB gene" S_feature 1442751..1442864 /Source="Nicolas_S_feature" /locus_tag="new_1530423_1530536" /HighExp="G150, LBGexp, MG-0.1, G180, C30, Diami, Oxctl, G135, ferm, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S532" promotor_-10 complement(1442785..1442804) /Source="Nicolas_upshift_promotors" /id="U1210" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.77022977022977" /psig="0.802197802197802" /xcortree=789 /SigmaFactorBS="ttctcgacctcctagtttgattaagcaattttaaagtttaCA TCgtaagcattgaaaaCAGATATATAATAGAGGGAAaacgttcatcttccctctcgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1442802) /Source="Nicolas_upshifts" /id="U1210" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.77022977022977" /psig="0.802197802197802" /xcortree=789 /SigmaFactorBS="ttctcgacctcctagtttgattaagcaattttaaagtttaCA TCgtaagcattgaaaaCAGATATATAATAGAGGGAAaacgttcatcttccctctcgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1442819..1442822) /Source="Nicolas_upshift_promotors" /id="U1210" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.77022977022977" /psig="0.802197802197802" /xcortree=789 /SigmaFactorBS="ttctcgacctcctagtttgattaagcaattttaaagtttaCA TCgtaagcattgaaaaCAGATATATAATAGAGGGAAaacgttcatcttccctctcgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1442865..1444193 /gene="pdhC" /locus_tag="BSU_14600" /old_locus_tag="BSU14600" /EC_number="2.3.1.12" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1784816, 9352926, 9588797, 10735853, 11976308, 22720735, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1784816, 9352926, 9588797, 10735853, 11976308, 22720735, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyruvate dehydrogenase (dihydrolipoamide acetyltransferase E2 subunit)" /protein_id="NP_389343.1" /db_xref="EnsemblGenomes-Gn:BSU14600" /db_xref="EnsemblGenomes-Tr:CAB13333" /db_xref="GOA:P21883" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR001078" /db_xref="InterPro:IPR003016" /db_xref="InterPro:IPR004167" /db_xref="InterPro:IPR011053" /db_xref="InterPro:IPR036625" /db_xref="SubtiList:BG10209" /db_xref="UniProtKB/Swiss-Prot:P21883" /translation="MAFEFKLPDIGEGIHEGEIVKWFVKPNDEVDEDDVLAEVQNDKA VVEIPSPVKGKVLELKVEEGTVATVGQTIITFDAPGYEDLQFKGSDESDDAKTEAQVQ STAEAGQDVAKEEQAQEPAKATGAGQQDQAEVDPNKRVIAMPSVRKYAREKGVDIRKV TGSGNNGRVVKEDIDSFVNGGAQEAAPQETAAPQETAAKPAAAPAPEGEFPETREKMS GIRKAIAKAMVNSKHTAPHVTLMDEVDVTNLVAHRKQFKQVAADQGIKLTYLPYVVKA LTSALKKFPVLNTSIDDKTDEVIQKHYFNIGIAADTEKGLLVPVVKNADRKSVFEISD EINGLATKAREGKLAPAEMKGASCTITNIGSAGGQWFTPVINHPEVAILGIGRIAEKA IVRDGEIVAAPVLALSLSFDHRMIDGATAQNALNHIKRLLNDPQLILMEA*" /label="pdhC CDS" gene 1442865..1444193 /gene="pdhC" /locus_tag="BSU_14600" /old_locus_tag="BSU14600" /label="pdhC gene" promotor_-35 1443009..1443016 /Source="Nicolas_upshift_promotors" /id="U1211" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.659340659340659" /psig="0.993006993006993" /xcortree=2451 /SigmaFactorBS="ctgaagtccaaaatgataaagcagtagtagaaattCCTTCAC CtgttaaaggaaaagTATTAGAATTAAAAGTTGAAgagggaacggttgcaactgttgg a" /listShort="pdhD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1443031..1443050 /Source="Nicolas_upshift_promotors" /id="U1211" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.659340659340659" /psig="0.993006993006993" /xcortree=2451 /SigmaFactorBS="ctgaagtccaaaatgataaagcagtagtagaaattCCTTCAC CtgttaaaggaaaagTATTAGAATTAAAAGTTGAAgagggaacggttgcaactgttgg a" /listShort="pdhD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1443034 /Source="Nicolas_upshifts" /id="U1211" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.659340659340659" /psig="0.993006993006993" /xcortree=2451 /SigmaFactorBS="ctgaagtccaaaatgataaagcagtagtagaaattCCTTCAC CtgttaaaggaaaagTATTAGAATTAAAAGTTGAAgagggaacggttgcaactgttgg a" /listShort="pdhD" /GFF_Attribute="listLong" /label="upshifts" CDS 1444198..1445610 /gene="pdhD" /locus_tag="BSU_14610" /old_locus_tag="BSU14610" /EC_number="1.8.1.4" /EC_number="1.2.1.25" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1784816, 6815422, 9352926, 9588797, 12682299, 21856851" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1784816, 6815422, 9352926, 9588797, 12682299, 21856851; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="dihydrolipoamide dehydrogenase E3 subunit of both pyruvate dehydrogenase and 2-oxoglutarate dehydrogenase complexes" /protein_id="NP_389344.1" /db_xref="EnsemblGenomes-Gn:BSU14610" /db_xref="EnsemblGenomes-Tr:CAB13334" /db_xref="GOA:P21880" /db_xref="InterPro:IPR001100" /db_xref="InterPro:IPR004099" /db_xref="InterPro:IPR006258" /db_xref="InterPro:IPR012999" /db_xref="InterPro:IPR016156" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG10210" /db_xref="UniProtKB/Swiss-Prot:P21880" /translation="MVVGDFPIETDTLVIGAGPGGYVAAIRAAQLGQKVTVVEKATLG GVCLNVGCIPSKALINAGHRYENAKHSDDMGITAENVTVDFTKVQEWKASVVNKLTGG VAGLLKGNKVDVVKGEAYFVDSNSVRVMDENSAQTYTFKNAIIATGSRPIELPNFKYS ERVLNSTGALALKEIPKKLVVIGGGYIGTELGTAYANFGTELVILEGGDEILPGFEKQ MSSLVTRRLKKKGNVEIHTNAMAKGVEERPDGVTVTFEVKGEEKTVDADYVLITVGRR PNTDELGLEQVGIEMTDRGIVKTDKQCRTNVPNIYAIGDIIEGPPLAHKASYEGKIAA EAIAGEPAEIDYLGIPAVVFSEPELASVGYTEAQAKEEGLDIVAAKFPFAANGRALSL NETDGFMKLITRKEDGLVIGAQIAGASASDMISELSLAIEGGMTAEDIAMTIHAHPTL GEITMEAAEVAIGSPIHIVK*" /label="pdhD CDS" gene 1444198..1445610 /gene="pdhD" /locus_tag="BSU_14610" /old_locus_tag="BSU14610" /label="pdhD gene" downshifts 1445607 /Source="Nicolas_upshifts" /id="D819" /incds=0 /nref=241 /ntot=268 /MaxReadThrough="1.82289" /MaxDrop="9.27853" /score="33.2247807" /energy="-12.1" /TU="NA" /idTUdmin="U1207" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1445655..1446029) /gene="slp" /locus_tag="BSU_14620" /old_locus_tag="BSU14620" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:1936936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1936936; Product type s : structure" /codon_start=1 /transl_table=11 /product="small peptidoglycan-associated lipoprotein" /protein_id="NP_389345.1" /db_xref="EnsemblGenomes-Gn:BSU14620" /db_xref="EnsemblGenomes-Tr:CAB13335" /db_xref="GOA:P39910" /db_xref="SubtiList:BG10211" /db_xref="UniProtKB/Swiss-Prot:P39910" /translation="MRYRAVFPMLIIVFALSGCTLSTINPMKKSRIDNIHHTQILFFS DENQIDQEAPYYDALLDLEKDYPEQIDKMKVYDKKEGWEDEIETVPTLMVVDQRHVVV KIEGCVKKKEDIIKPLQHVLSK*" /label="slp CDS" gene complement(1445655..1446029) /gene="slp" /locus_tag="BSU_14620" /old_locus_tag="BSU14620" /label="slp gene" downshifts complement(1445703) /Source="Nicolas_upshifts" /id="D820" /incds=0 /nref=26 /ntot=132 /MaxReadThrough="1.54024" /MaxDrop="3.69756" /score="4.23955997" /energy="-12.1" /TU="NA" /idTUdmin="U1212" /TUdmin=3 /isTUend="TRUE" /label="downshifts" misc_feature complement(1446060..1446079) /Source="Nicolas_upshift_promotors" /id="U1212" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=581 /SigmaFactorBS="ggtttcaattatataacaattaggtaacaagaagcagattaa gccgtctctCGTGATAAACTAAAGCTAGTtaactactgtttatacagaggagaagata g" /listShort="slp" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1446070) /Source="Nicolas_upshifts" /id="U1212" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=581 /SigmaFactorBS="ggtttcaattatataacaattaggtaacaagaagcagattaa gccgtctctCGTGATAAACTAAAGCTAGTtaactactgtttatacagaggagaagata g" /listShort="slp" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1446233..1446238 /Source="Nicolas_upshift_promotors" /id="U1213" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1078 /SigmaFactorBS="cattcttggatgaaagttcaagaaaacgtGCAATTacattat gtgctgtgGCATATATATCGAGTAAAGcttctgtatgaagaagatattgtatgatgga a" /listShort="S533, ykzW" /listLong="S534, yktA" /label="promotor_-35" promotor_-10 1446254..1446272 /Source="Nicolas_upshift_promotors" /id="U1213" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1078 /SigmaFactorBS="cattcttggatgaaagttcaagaaaacgtGCAATTacattat gtgctgtgGCATATATATCGAGTAAAGcttctgtatgaagaagatattgtatgatgga a" /listShort="S533, ykzW" /listLong="S534, yktA" /label="promotor_-10" upshifts 1446264 /Source="Nicolas_upshifts" /id="U1213" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1078 /SigmaFactorBS="cattcttggatgaaagttcaagaaaacgtGCAATTacattat gtgctgtgGCATATATATCGAGTAAAGcttctgtatgaagaagatattgtatgatgga a" /listShort="S533, ykzW" /listLong="S534, yktA" /label="upshifts" S_feature 1446268..1446377 /Source="Nicolas_S_feature" /locus_tag="new_1533940_1534049" /HighExp="S4, S5, S7, S6, S8, S3, BT, G/S, LoTm, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S533" downshifts complement(1446300) /Source="Nicolas_upshifts" /id="D821" /incds=0 /nref=4 /ntot=18 /MaxReadThrough="1.96608" /MaxDrop="3.4036" /score="51.898567" /energy="-16.8" /TU="NA" /idTUdmin="U1215" /TUdmin=308 /isTUend="FALSE" /label="downshifts" promotor_-35 1446361..1446368 /Source="Nicolas_upshift_promotors" /id="U1214" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=346 /SigmaFactorBS="gtgaatatgatgatatgaaataaaatgtgttatacagtttgt TGTTGACAttttaaatgtgacaTATTAATATAATAACAACAAaagaaattaagcgttt t" /listShort="ykzW, S534, yktA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1446379 /Source="Nicolas_upshifts" /id="U1214" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=346 /SigmaFactorBS="gtgaatatgatgatatgaaataaaatgtgttatacagtttgt TGTTGACAttttaaatgtgacaTATTAATATAATAACAACAAaagaaattaagcgttt t" /listShort="ykzW, S534, yktA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1446383..1446402 /Source="Nicolas_upshift_promotors" /id="U1214" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=346 /SigmaFactorBS="gtgaatatgatgatatgaaataaaatgtgttatacagtttgt TGTTGACAttttaaatgtgacaTATTAATATAATAACAACAAaagaaattaagcgttt t" /listShort="ykzW, S534, yktA" /GFF_Attribute="listLong" /label="promotor_-10" misc_RNA 1446398..1446608 /gene="srrA" /locus_tag="BSU_misc_RNA_70" /product="small regulatory RNA and messenger RNA (argininemetabolism)" /experiment="publication(s) with functional evidences, PMID:16164558, 17011578, 17020585, 17576690, 18511073, 18586936, 19726675, 20444087, 27449348" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16164558, 17011578, 17020585, 17576690, 18511073, 18586936, 19726675, 20444087, 27449348; Product type n: RNA" /function="16.3: Control" /label="srrA RNA" gene 1446398..1446608 /gene="srrA" /locus_tag="BSU_misc_RNA_70" /label="srrA gene" CDS 1446448..1446567 /gene="rgpA" /locus_tag="BSU_14629" /old_locus_tag="BSU14629" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16164558, 20444087, 27449348" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16164558, 20444087, 27449348; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of GapA synthesis" /protein_id="YP_003097726.1" /db_xref="EnsemblGenomes-Gn:BSU14629" /db_xref="EnsemblGenomes-Tr:CAX52617" /db_xref="InterPro:IPR025236" /db_xref="UniProtKB/Swiss-Prot:C0H410" /translation="MGTIVCQDCNEAIHYFEDEKVTTLYGTCCGQCQCPVDEE*" /label="rgpA CDS" gene 1446448..1446567 /gene="rgpA" /locus_tag="BSU_14629" /old_locus_tag="BSU14629" /label="rgpA gene" downshifts complement(1446454) /Source="Nicolas_upshifts" /id="D822" /incds=0 /nref=6 /ntot=35 /MaxReadThrough="3.43398" /MaxDrop="4.36472" /score="51.898567" /energy="-16.8" /TU="NA" /idTUdmin="U1215" /TUdmin=154 /isTUend="FALSE" /label="downshifts" downshifts 1446554 /Source="Nicolas_upshifts" /id="D823" /incds=0 /nref=59 /ntot=171 /MaxReadThrough="5.69396" /MaxDrop="7.24152" /score="51.2534618" /energy="-16.8" /TU="U1214" /idTUdmin="U1213" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1446599..1448202 /Source="Nicolas_S_feature" /locus_tag="new_1534271_1535874" /HighExp="M9-stat, M0t90, B60, M40t90, T1.30H, T2.0H, T2.30H, T3.30H, T3.0H, T0.30H" /AntisenseName="speA" /AntisenseCor="-0.33575411980382203" /AntisenseRegPval="-7.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig="0.998" /label="S534" CDS complement(1446607..1448079) /gene="speA" /locus_tag="BSU_14630" /old_locus_tag="BSU14630" /EC_number="4.1.1.19" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9723923, 19114526, 19255484, 20876533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9723923, 19114526, 19255484, 20876533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arginine decarboxylase" /protein_id="NP_389346.1" /db_xref="EnsemblGenomes-Gn:BSU14630" /db_xref="EnsemblGenomes-Tr:CAB13336" /db_xref="GOA:P21885" /db_xref="InterPro:IPR000310" /db_xref="InterPro:IPR008286" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036633" /db_xref="SubtiList:BG10212" /db_xref="UniProtKB/Swiss-Prot:P21885" /translation="MSQHETPLYTGLKKHASRQPVQFHIPGHKKGAGMDPEFRQFIGE NALSIDLINIEPLDDLHAPKGIIKQAQDLAAEAFGADHTFFSVQGTSGAIMTMVMAVC GPGDKIIIPRNVHKSIMTAIVFSGAVPIFIHPEIDNELGISHGITLESAKRALTEHPD AKGLLVINPTYFGVAADLKSIVELAHSFDVPVLVDEAHGVHIHFHDELPLSAMQAGAD IAATSVHKLGGSLTQSSILNMREGLVSKDRVQSILSMLTTTSTSYLLLASLDVARKRL ATEGRQLAEETLKLANQTRDRLNQIEGIYCVGSEILGSKAAYSYDPTKLIISVKSLGL TGHDVEKWLRESFNIEVELSDLYNILCIFTPGDSQNDADRLVEALTEIAQQMSEQDVT HQQTEVLLPEIPLLAMTPRDAFYANTEVIPLKEASGRIIAEFVMVYPPGIPIFIPGEI ITEENISYIFKNLDAGLPVQGPEDSTLHMIRVIKEQKAIQ*" /label="speA CDS" gene complement(1446607..1448079) /gene="speA" /locus_tag="BSU_14630" /old_locus_tag="BSU14630" /label="speA gene" downshifts complement(1446625) /Source="Nicolas_upshifts" /id="D824" /incds=0 /nref=62 /ntot=198 /MaxReadThrough="3.88498" /MaxDrop="6.76978" /score="51.898567" /energy="-16.8" /TU="NA" /idTUdmin="U1215" /TUdmin="-17" /isTUend="TRUE" /label="downshifts" S_feature complement(1448080..1448175) /Source="Nicolas_S_feature" /locus_tag="new_1535752_1535847_c" /HighExp="Paraq, G180, LBGexp, Oxctl, G150, G135, C30, H2O2, BMM, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S535" promotor_-10 complement(1448158..1448177) /Source="Nicolas_upshift_promotors" /id="U1215" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=2477 /SigmaFactorBS="cttaagagaaagcatcttcatttgatcataaattgtTCTTTA CAttctttcaagttcaTAATATAATTCATTTGTTTTacgtctaaaaaacggttgagaa a" /listShort="S535, speA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1448175) /Source="Nicolas_upshifts" /id="U1215" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=2477 /SigmaFactorBS="cttaagagaaagcatcttcatttgatcataaattgtTCTTTA CAttctttcaagttcaTAATATAATTCATTTGTTTTacgtctaaaaaacggttgagaa a" /listShort="S535, speA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1448182..1448185 /Source="Nicolas_upshift_promotors" /id="U1216" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.675324675324675" /psig=1 /xcortree=2377 /SigmaFactorBS="cgttttttagacgtaaaacaaatgaattatattatgaaCTTG aaagaatgtaaagaACAATTTATGATCAAATGAAgatgctttctcttaagggaagtaa a" /listShort="yktA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(1448192..1448199) /Source="Nicolas_upshift_promotors" /id="U1215" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=2477 /SigmaFactorBS="cttaagagaaagcatcttcatttgatcataaattgtTCTTTA CAttctttcaagttcaTAATATAATTCATTTGTTTTacgtctaaaaaacggttgagaa a" /listShort="S535, speA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1448200..1448219 /Source="Nicolas_upshift_promotors" /id="U1216" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.675324675324675" /psig=1 /xcortree=2377 /SigmaFactorBS="cgttttttagacgtaaaacaaatgaattatattatgaaCTTG aaagaatgtaaagaACAATTTATGATCAAATGAAgatgctttctcttaagggaagtaa a" /listShort="yktA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1448204 /Source="Nicolas_upshifts" /id="U1216" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.675324675324675" /psig=1 /xcortree=2377 /SigmaFactorBS="cgttttttagacgtaaaacaaatgaattatattatgaaCTTG aaagaatgtaaagaACAATTTATGATCAAATGAAgatgctttctcttaagggaagtaa a" /listShort="yktA" /GFF_Attribute="listLong" /label="upshifts" CDS 1448264..1448530 /gene="yktA" /locus_tag="BSU_14640" /old_locus_tag="BSU14640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 19429628, 22333191" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389347.1" /db_xref="EnsemblGenomes-Gn:BSU14640" /db_xref="EnsemblGenomes-Tr:CAB13337" /db_xref="InterPro:IPR007920" /db_xref="InterPro:IPR023324" /db_xref="SubtiList:BG11816" /db_xref="UniProtKB/Swiss-Prot:Q45497" /translation="MEYQYPMNEDWTTEEAVDVIAFFQQVELAYEKGADREELLKAYR RFKEIVPGKAEEKKLCGEFEEQSTYSPYRTVKQARESDHAKIKM*" /label="yktA CDS" gene 1448264..1448530 /gene="yktA" /locus_tag="BSU_14640" /old_locus_tag="BSU14640" /label="yktA gene" downshifts 1448512 /Source="Nicolas_upshifts" /id="D825" /incds=0 /nref=105 /ntot=250 /MaxReadThrough="2.62284" /MaxDrop="5.09814" /score="40.0811023" /energy="-16.1" /TU="NA" /idTUdmin="U1214" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1448563..1449201) /gene="yktB" /locus_tag="BSU_14650" /old_locus_tag="BSU14650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 25643072" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389348.1" /db_xref="EnsemblGenomes-Gn:BSU14650" /db_xref="EnsemblGenomes-Tr:CAB13338" /db_xref="InterPro:IPR009403" /db_xref="PDB:2A8E" /db_xref="SubtiList:BG11817" /db_xref="UniProtKB/Swiss-Prot:Q45498" /translation="MTQMRFTEEDFNTFTIEGLDARMEVLKETVRPKLTALGEHFAPT LSALTGDEMFPHVAKHARRSVNPPADSWVAFANSKRGYKKLPHFQIGLWESHVFVWFA IIYESPIKEEYGKLLEVNQETITKNIPDSFVWSADHTKPGVHKQSEMDKEQLKTLFER LQTVKKAELLCGIQLQKEEVLNMNNQEFLQRIDDAFKQLAFLYRLTQKVTQA*" /label="yktB CDS" gene complement(1448563..1449201) /gene="yktB" /locus_tag="BSU_14650" /old_locus_tag="BSU14650" /label="yktB gene" downshifts complement(1448588) /Source="Nicolas_upshifts" /id="D826" /incds=0 /nref=184 /ntot=257 /MaxReadThrough="2.62959" /MaxDrop="6.54203" /score="26.7765804" /energy="-14.5" /TU="U1217" /idTUdmin="U1217" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1449222..1449241) /Source="Nicolas_upshift_promotors" /id="U1217" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.519480519480519" /psig="0.997002997002997" /xcortree=2002 /SigmaFactorBS="actcgtttattaccacatttctccttacttcaaacgcgctca atctTTTTGaagctcgtatgaacTGTGATAAAATATGTATACTtagcatgaaggagga a" /listShort="yktB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1449246) /Source="Nicolas_upshifts" /id="U1217" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.519480519480519" /psig="0.997002997002997" /xcortree=2002 /SigmaFactorBS="actcgtttattaccacatttctccttacttcaaacgcgctca atctTTTTGaagctcgtatgaacTGTGATAAAATATGTATACTtagcatgaaggagga a" /listShort="yktB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1449256..1449260) /Source="Nicolas_upshift_promotors" /id="U1217" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.519480519480519" /psig="0.997002997002997" /xcortree=2002 /SigmaFactorBS="actcgtttattaccacatttctccttacttcaaacgcgctca atctTTTTGaagctcgtatgaacTGTGATAAAATATGTATACTtagcatgaaggagga a" /listShort="yktB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1449271..1449277 /Source="Nicolas_upshift_promotors" /id="U1218" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=209 /SigmaFactorBS="tttatcacagttcatacgagcttcaaaaagattgagcgCGTT TGAagtaaggagaaatgTGGTAATAAACGAGTAGGTaaacacacaattttcagaatca t" /listShort="S536, ykzI, suhB, ykzC, S537" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1449292..1449310 /Source="Nicolas_upshift_promotors" /id="U1218" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=209 /SigmaFactorBS="tttatcacagttcatacgagcttcaaaaagattgagcgCGTT TGAagtaaggagaaatgTGGTAATAAACGAGTAGGTaaacacacaattttcagaatca t" /listShort="S536, ykzI, suhB, ykzC, S537" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1449293 /Source="Nicolas_upshifts" /id="U1218" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=209 /SigmaFactorBS="tttatcacagttcatacgagcttcaaaaagattgagcgCGTT TGAagtaaggagaaatgTGGTAATAAACGAGTAGGTaaacacacaattttcagaatca t" /listShort="S536, ykzI, suhB, ykzC, S537" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1449331..1449340 /Source="Nicolas_upshift_promotors" /id="U1219" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1258 /SigmaFactorBS="ataaacgagtaggtaaacacacaattttcagaatCATGTTGC GCgtaaatagaacaATCATACGATATAAGAAGTAatcattgttgaatggcaaaatggg a" /listShort="S536, ykzI, suhB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1449353..1449372 /Source="Nicolas_upshift_promotors" /id="U1219" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1258 /SigmaFactorBS="ataaacgagtaggtaaacacacaattttcagaatCATGTTGC GCgtaaatagaacaATCATACGATATAAGAAGTAatcattgttgaatggcaaaatggg a" /listShort="S536, ykzI, suhB" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1449357..1449440 /Source="Nicolas_S_feature" /locus_tag="new_1537029_1537112" /HighExp="Etha, S7, M9-stat, S6, S8, BT, Gly, Salt, B60, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigB" /TUshortPSig="0.987, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S536" upshifts 1449357 /Source="Nicolas_upshifts" /id="U1219" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1258 /SigmaFactorBS="ataaacgagtaggtaaacacacaattttcagaatCATGTTGC GCgtaaatagaacaATCATACGATATAAGAAGTAatcattgttgaatggcaaaatggg a" /listShort="S536, ykzI, suhB" /GFF_Attribute="listLong" /label="upshifts" CDS 1449441..1449629 /gene="ykzI" /locus_tag="BSU_14660" /old_locus_tag="BSU14660" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved general stress protein" /protein_id="NP_389349.1" /db_xref="EnsemblGenomes-Gn:BSU14660" /db_xref="EnsemblGenomes-Tr:CAB13339" /db_xref="SubtiList:BG13337" /db_xref="UniProtKB/Swiss-Prot:O31719" /translation="MRQVVKEGFKEEKNNRVAVWRLEVDYELATLYEAMQKENEEQIE QSKNKLERLRKEWIRLNG*" /label="ykzI CDS" gene 1449441..1449629 /gene="ykzI" /locus_tag="BSU_14660" /old_locus_tag="BSU14660" /label="ykzI gene" downshifts complement(1449446) /Source="Nicolas_upshifts" /id="D827" /incds=0 /nref=1 /ntot=15 /MaxReadThrough="1.50398" /MaxDrop="3.97385" /score="26.7765804" /energy="-14.5" /TU="NA" /idTUdmin="U1220" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 1449622 /Source="Nicolas_upshifts" /id="D828" /incds=0 /nref=13 /ntot=45 /MaxReadThrough="7.33866" /MaxDrop="6.12123" /score="-8.73613673" /energy="-8.1" /TU="U1218,U1219" /idTUdmin="U1219" /TUdmin="-628" /isTUend="FALSE" /label="downshifts" upshifts complement(1449644) /Source="Nicolas_upshifts" /id="U1220" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.616383616383616" /psig="0.105894105894106" /xcortree=118 /SigmaFactorBS="agcaaggaaaatgaaaaatatcccttctcacgtaaaaacgaa ccattcaTGCGgttcgttttcactatcgcttttttacccgttaagacgaatccattct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(1449652..1449655) /Source="Nicolas_upshift_promotors" /id="U1220" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.616383616383616" /psig="0.105894105894106" /xcortree=118 /SigmaFactorBS="agcaaggaaaatgaaaaatatcccttctcacgtaaaaacgaa ccattcaTGCGgttcgttttcactatcgcttttttacccgttaagacgaatccattct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-35 1449699..1449702 /Source="Nicolas_upshift_promotors" /id="U1221" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.519480519480519" /psig=1 /xcortree=1962 /SigmaFactorBS="gttcgtttttacgtgagaagggatatttttcattttcCTTGc tttttcattgccgttATCAGTATCCTATAAAATAAaaggtctacatagaagagaggta c" /listShort="suhB, ykzC, S537" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1449719..1449738 /Source="Nicolas_upshift_promotors" /id="U1221" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.519480519480519" /psig=1 /xcortree=1962 /SigmaFactorBS="gttcgtttttacgtgagaagggatatttttcattttcCTTGc tttttcattgccgttATCAGTATCCTATAAAATAAaaggtctacatagaagagaggta c" /listShort="suhB, ykzC, S537" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1449722 /Source="Nicolas_upshifts" /id="U1221" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.519480519480519" /psig=1 /xcortree=1962 /SigmaFactorBS="gttcgtttttacgtgagaagggatatttttcattttcCTTGc tttttcattgccgttATCAGTATCCTATAAAATAAaaggtctacatagaagagaggta c" /listShort="suhB, ykzC, S537" /GFF_Attribute="listLong" /label="upshifts" CDS 1449769..1450566 /gene="suhB" /locus_tag="BSU_14670" /old_locus_tag="BSU14670" /EC_number="3.1.3.-" /EC_number="3.1.3.25" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11914086, 16682444, 22333191, 27784292" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11914086, 16682444, 22333191, 27784292; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="inositol monophosphatase / 5' nucleotidase (purine nucleoside monophosphate)" /protein_id="NP_389350.1" /db_xref="EnsemblGenomes-Gn:BSU14670" /db_xref="EnsemblGenomes-Tr:CAB13340" /db_xref="GOA:Q45499" /db_xref="InterPro:IPR000760" /db_xref="InterPro:IPR020550" /db_xref="InterPro:IPR020583" /db_xref="InterPro:IPR033942" /db_xref="SubtiList:BG11818" /db_xref="UniProtKB/Swiss-Prot:Q45499" /translation="MTNWTEIDEIAKKWIREAGARITQSMHESLTIETKSNPNDLVTN IDKETEKFFIDRIQETFPGHRILGEEGQGDKIHSLEGVVWIIDPIDGTMNFVHQQRNF AISIGIFENGEGKIGLIYDVVHDELYHAFSGRGAYMNETKLAPLKETVIEEAILAINA TWVTENRRIDQSVLAPLVKRVRGTRSYGSAALELANVAAGRIDAYITMRLAPWDYAAG CVLLNEVGGTYTTIEGEPFTFLENHSVLAGNPSIHKTIFEEYLHARK*" /label="suhB CDS" gene 1449769..1450566 /gene="suhB" /locus_tag="BSU_14670" /old_locus_tag="BSU14670" /label="suhB gene" CDS 1450592..1451020 /gene="ykzC" /locus_tag="BSU_14680" /old_locus_tag="BSU14680" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11544224; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyltransferase" /protein_id="NP_389351.1" /db_xref="EnsemblGenomes-Gn:BSU14680" /db_xref="EnsemblGenomes-Tr:CAB13341" /db_xref="GOA:O31720" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13331" /db_xref="UniProtKB/Swiss-Prot:O31720" /translation="MLEKLAEAHPVWKEEEFGDKDAEDYIISYSMYNGSWLVWEKDGM PVAVSYHLEWSPSNGKPWLGTVLIDPAEEKKGHAKMIIEQISKLLRAKHKAMFAGVPI ERREWILFLSQCGFEQLKTEKDEKGKSFMILVKPLAEAAV*" /label="ykzC CDS" gene 1450592..1451020 /gene="ykzC" /locus_tag="BSU_14680" /old_locus_tag="BSU14680" /label="ykzC gene" downshifts 1450977 /Source="Nicolas_upshifts" /id="D829" /incds=0 /nref=80 /ntot=232 /MaxReadThrough="4.50069" /MaxDrop="4.3098" /score="-9.99315734" /energy="-11.8" /TU="U1218,U1221" /idTUdmin="U1218" /TUdmin="-153" /isTUend="FALSE" /label="downshifts" S_feature 1451021..1451974 /Source="Nicolas_S_feature" /locus_tag="new_1538693_1539646" /HighExp="H2O2, dia15, Diami, Paraq, G180, G135, G150, dia5, Heat, LBGexp" /AntisenseName="yktD" /AntisenseCor="-1.5120906229522399E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="0.117724" /TUshortSig="SigA, SigB" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S537" downshifts complement(1451096) /Source="Nicolas_upshifts" /id="D830" /incds=0 /nref=4 /ntot=85 /MaxReadThrough="0.88821" /MaxDrop="3.44773" /score="19.9363134" /energy="-12.8" /TU="NA" /idTUdmin="U1222" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1451098..1452012) /gene="yktD" /locus_tag="BSU_14690" /old_locus_tag="BSU14690" /EC_number="2.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17928718; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative AdoMet-dependent methyltransferase" /protein_id="NP_389352.1" /db_xref="EnsemblGenomes-Gn:BSU14690" /db_xref="EnsemblGenomes-Tr:CAB13342" /db_xref="GOA:Q45500" /db_xref="InterPro:IPR007213" /db_xref="InterPro:IPR011610" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11819" /db_xref="UniProtKB/Swiss-Prot:Q45500" /translation="MRKNESSLTSLISAFARAYHSRYDTPLIFDDFIAKDLINEKEFI DISKNMIQEISFFNKEIAERLQNDPEKILKWVAQIQLSPTPLARASYCEKVLHNELIL GAKQYVILGAGLDTFCFRHPELENSLQVFEVDHPATQQLKKNKLKDANLTIPGHLHFV PMDFTKTFSYDPLLDEGFKNTKTFFSLLGVSYYVTREENASLISNLFSHVPPGSSIVF DYADETLFTAKGTSNRVEHMVKMAAASGEPMKSCFTYQEIEHLLESSGLLIYEHLSPD DINDLFFSNRKDNLSAFETIHYIHAVKK*" /label="yktD CDS" gene complement(1451098..1452012) /gene="yktD" /locus_tag="BSU_14690" /old_locus_tag="BSU14690" /label="yktD gene" promotor_-10 complement(1452078..1452097) /Source="Nicolas_upshift_promotors" /id="U1222" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=584 /SigmaFactorBS="gatcgcgcgtccagttaagagcaaaaaCATTGACAaaaaaat ttatttaTGCTAAAATTTACTATTAATatatttgtatgtataataagattctcctggc c" /listShort="yktD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1452086) /Source="Nicolas_upshifts" /id="U1222" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=584 /SigmaFactorBS="gatcgcgcgtccagttaagagcaaaaaCATTGACAaaaaaat ttatttaTGCTAAAATTTACTATTAATatatttgtatgtataataagattctcctggc c" /listShort="yktD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1452112..1452119) /Source="Nicolas_upshift_promotors" /id="U1222" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=584 /SigmaFactorBS="gatcgcgcgtccagttaagagcaaaaaCATTGACAaaaaaat ttatttaTGCTAAAATTTACTATTAATatatttgtatgtataataagattctcctggc c" /listShort="yktD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1452364..1453929) /gene="nprE" /locus_tag="BSU_14700" /old_locus_tag="BSU14700" /EC_number="3.4.24.28" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2128597, 6090407, 8436952, 15205417, 26728191" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2128597, 6090407, 8436952, 15205417, 26728191; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="extracellular neutral metalloprotease" /protein_id="NP_389353.1" /db_xref="EnsemblGenomes-Gn:BSU14700" /db_xref="EnsemblGenomes-Tr:CAB13343" /db_xref="GOA:P68736" /db_xref="InterPro:IPR001570" /db_xref="InterPro:IPR011096" /db_xref="InterPro:IPR013856" /db_xref="InterPro:IPR023612" /db_xref="InterPro:IPR025711" /db_xref="SubtiList:BG10448" /db_xref="UniProtKB/Swiss-Prot:P68736" /translation="MGLGKKLSVAVAASFMSLSISLPGVQAAEGHQLKENQTNFLSKN AIAQSELSAPNDKAVKQFLKKNSNIFKGDPSKRLKLVESTTDALGYKHFRYAPVVNGV PIKDSQVIVHVDKSDNVYAVNGELHNQSAAKTDNSQKVSSEKALALAFKAIGKSPDAV SNGAAKNSNKAELKAIETKDGSYRLAYDVTIRYVEPEPANWEVLVDAETGSILKQQNK VEHAAATGSGTTLKGATVPLNISYEGGKYVLRDLSKPTGTQIITYDLQNRQSRLPGTL VSSTTKTFTSSSQRAAVDAHYNLGKVYDYFYSNFKRNSYDNKGSKIVSSVHYGTQYNN AAWTGDQMIYGDGDGSFFSPLSGSLDVTAHEMTHGVTQETANLIYENQPGALNESFSD VFGYFNDTEDWDIGEDITVSQPALRSLSNPTKYNQPDNYANYRNLPNTDEGDYGGVHT NSGIPNKAAYNTITKLGVSKSQQIYYRALTTYLTPSSTFKDAKAALIQSARDLYGSTD AAKVEAAWNAVGL*" /label="nprE CDS" gene complement(1452364..1453929) /gene="nprE" /locus_tag="BSU_14700" /old_locus_tag="BSU14700" /label="nprE gene" promotor_-10 complement(1453964..1453983) /Source="Nicolas_upshift_promotors" /id="U1223" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.526473526473527" /psig="0.993006993006993" /xcortree=3157 /SigmaFactorBS="tactatcaattttgtctagttatgttagtttTTGTTGAGtat tccagaatgcTAGTTTAATATAACAATATAaagttttcagtattttcaaaaaggggga t" /listShort="nprE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1453975) /Source="Nicolas_upshifts" /id="U1223" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.526473526473527" /psig="0.993006993006993" /xcortree=3157 /SigmaFactorBS="tactatcaattttgtctagttatgttagtttTTGTTGAGtat tccagaatgcTAGTTTAATATAACAATATAaagttttcagtattttcaaaaaggggga t" /listShort="nprE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1453997..1454004) /Source="Nicolas_upshift_promotors" /id="U1223" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.526473526473527" /psig="0.993006993006993" /xcortree=3157 /SigmaFactorBS="tactatcaattttgtctagttatgttagtttTTGTTGAGtat tccagaatgcTAGTTTAATATAACAATATAaagttttcagtattttcaaaaaggggga t" /listShort="nprE" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1454214..1456154 /gene="ylaA" /locus_tag="BSU_14710" /old_locus_tag="BSU14710" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16501307" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389354.1" /db_xref="EnsemblGenomes-Gn:BSU14710" /db_xref="EnsemblGenomes-Tr:CAB13344" /db_xref="GOA:O07625" /db_xref="SubtiList:BG13338" /db_xref="UniProtKB/Swiss-Prot:O07625" /translation="MLFVLELFSHYVLHFERYFILSRQSTLLIQWSIVVLAGLYLLVH HPKINRQRTMFLAGVILRIVLLAGVSVELIHQVQSTNFTSAYLREDGKELLPLLHFLL YGYVLLTAFHYMLMPRDHGGKGKFYTFDLAVVSLPIVQMIFSFFSYWKEYPDGMEPIA FVFLFFIITLPIALNVVFFKLYWRTDKILLGLFYTLIIGLLVLLLAPYPNQISKDYGA VMPYTIYLAMAGFLMSYHLFQKSGKVYVRVNKWVTMAVMVFFVLLLNPIYNIGTAAFA VSKPANVHDSFNFVGEHISSEKAEQILKSFFPTDETLYLHDTNMDVHYFYSFESKGYK AEVDEVSQLIRNYEYLQKAHGKKLTNQEYKRKSIAFLERHGRVLHKDHIETKVSQEDG QTVVRIYLKNQLHKKDHADDGAVFYWEKETLMGFSEDPSIYQLDSLLHVHITEQDIHD KVEQMFTALNISKQPYQITDIESDSLLGSMVRVETKVGIVLEFEGESGCLHSLSLPMK KNISMANSRLQHQILSIFDARGSEKKKKSSQGDMVMYTDSSKTYEFVEAQGQLNVYVY SDTPDQSFPYTYRNGTLAYEKVASLYQDVIYKKRMRPIIVQRGDERHYAWLIIIQPFG SNRHDAYVVDGETQEVKSLYES*" /label="ylaA CDS" gene 1454214..1456154 /gene="ylaA" /locus_tag="BSU_14710" /old_locus_tag="BSU14710" /label="ylaA gene" CDS 1456144..1456413 /gene="ylaB" /locus_tag="BSU_14720" /old_locus_tag="BSU14720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 16501307" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_389355.1" /db_xref="EnsemblGenomes-Gn:BSU14720" /db_xref="EnsemblGenomes-Tr:CAB13345" /db_xref="GOA:O07626" /db_xref="SubtiList:BG13339" /db_xref="UniProtKB/Swiss-Prot:O07626" /translation="MNHKEKESVFVDLYDLYKEGELEDESMEWMKQHESLFQKNAEDL KSKTCLKRSPGAEEESQIRYMKVYLSSMYICFILLAIWMTVWFYF*" /label="ylaB CDS" gene 1456144..1456413 /gene="ylaB" /locus_tag="BSU_14720" /old_locus_tag="BSU14720" /label="ylaB gene" promotor_-35 1456379..1456383 /Source="Nicolas_upshift_promotors" /id="U1224" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.312687312687313" /psig="0.985014985014985" /xcortree=2008 /SigmaFactorBS="gtcttccatgtatatctgtttcattttatTGGCCaTTtggat gacggTGTGGTTTTATTTTTAATGAagcatagggattccattgaggacttgtatcggc a" /listShort="ylaC, ylaD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1456397..1456416 /Source="Nicolas_upshift_promotors" /id="U1224" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.312687312687313" /psig="0.985014985014985" /xcortree=2008 /SigmaFactorBS="gtcttccatgtatatctgtttcattttatTGGCCaTTtggat gacggTGTGGTTTTATTTTTAATGAagcatagggattccattgaggacttgtatcggc a" /listShort="ylaC, ylaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1456410 /Source="Nicolas_upshifts" /id="U1224" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.312687312687313" /psig="0.985014985014985" /xcortree=2008 /SigmaFactorBS="gtcttccatgtatatctgtttcattttatTGGCCaTTtggat gacggTGTGGTTTTATTTTTAATGAagcatagggattccattgaggacttgtatcggc a" /listShort="ylaC, ylaD" /GFF_Attribute="listLong" /label="upshifts" CDS 1456413..1456934 /gene="sigP" /locus_tag="BSU_14730" /old_locus_tag="BSU14730" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16501307, 16728958, 20817771" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16501307, 16728958, 20817771; Product type r: regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase ECF-type sigma factor" /protein_id="NP_389356.1" /db_xref="EnsemblGenomes-Gn:BSU14730" /db_xref="EnsemblGenomes-Tr:CAB13346" /db_xref="GOA:O07627" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR014296" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG13340" /db_xref="UniProtKB/Swiss-Prot:O07627" /translation="MKHRDSIEDLYRQYYQEILNYLFRRTHHLETAKDLAQDTFVKAL NGLASFRGHSSIRTWLYTIAHHTFINWYRRDVKYQFTEISKNEGLTQTTYDQPEQYLS RTVKSETLRQELLKLKDQHQSVLILREFQELSYEEIAEILGWSLSKVNTTLHRARLEL KKNMTKSREEERI*" /label="sigP CDS" gene 1456413..1456934 /gene="sigP" /locus_tag="BSU_14730" /old_locus_tag="BSU14730" /label="sigP gene" CDS 1456931..1457224 /gene="sigQ" /locus_tag="BSU_14740" /old_locus_tag="BSU14740" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16501307, 16728958, 20817771" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16501307, 16728958, 20817771; Product type r: regulator" /codon_start=1 /transl_table=11 /product="anti-SigP(YlaC) sigma factor" /protein_id="NP_389357.1" /db_xref="EnsemblGenomes-Gn:BSU14740" /db_xref="EnsemblGenomes-Tr:CAB13347" /db_xref="GOA:O07628" /db_xref="InterPro:IPR027383" /db_xref="SubtiList:BG13341" /db_xref="UniProtKB/Swiss-Prot:O07628" /translation="MTCFLVRDLLPLYLEGDCKRETEHVIEEHLKMCSSCRDMYDTMA EPFELESEQAVEEAYLPEEELRFKQRYYGLLIMKAACWFGAAVAMMLIIKLLI*" /label="sigQ CDS" gene 1456931..1457224 /gene="sigQ" /locus_tag="BSU_14740" /old_locus_tag="BSU14740" /label="sigQ gene" CDS complement(1457264..1457875) /gene="ylaE" /locus_tag="BSU_14750" /old_locus_tag="BSU14750" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_389358.1" /db_xref="EnsemblGenomes-Gn:BSU14750" /db_xref="EnsemblGenomes-Tr:CAB13348" /db_xref="SubtiList:BG13342" /db_xref="UniProtKB/Swiss-Prot:O07629" /translation="MKKTFVKKAMLTTAAMTSAALLTFGPDAASAKTPVDNTAVQLQH QASTNEDLNTFIDILNQCIYEQDGVYYFDSEKAVELGMTKEEAQVIATLWESTSEFFS IVSQCVYLEDGNYKFDTEKAVELGFTEKEALALEQFFSAVSLKIHILQAAIVLQDDVY SYDKDAALQAGATPLQADVYEKLFSALSQEQLAAIYDMIHPQA*" /label="ylaE CDS" gene complement(1457264..1457875) /gene="ylaE" /locus_tag="BSU_14750" /old_locus_tag="BSU14750" /label="ylaE gene" downshifts complement(1457278) /Source="Nicolas_upshifts" /id="D831" /incds=0 /nref=44 /ntot=184 /MaxReadThrough="1.37453" /MaxDrop="4.23106" /score="20.8244305" /energy="-11.7" /TU="NA" /idTUdmin="U1225" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1457907..1457926) /Source="Nicolas_upshift_promotors" /id="U1225" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.956043956043956" /xcortree=3078 /SigmaFactorBS="ggcaacgatacacataaaataccatagcgcctATTCctccac cggaaactACTCCCTATAATGGAATTTGtagcacaattcataaaagggagagaagaaa c" /listShort="ylaE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1457916) /Source="Nicolas_upshifts" /id="U1225" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.956043956043956" /xcortree=3078 /SigmaFactorBS="ggcaacgatacacataaaataccatagcgcctATTCctccac cggaaactACTCCCTATAATGGAATTTGtagcacaattcataaaagggagagaagaaa c" /listShort="ylaE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1457941..1457944) /Source="Nicolas_upshift_promotors" /id="U1225" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.956043956043956" /xcortree=3078 /SigmaFactorBS="ggcaacgatacacataaaataccatagcgcctATTCctccac cggaaactACTCCCTATAATGGAATTTGtagcacaattcataaaagggagagaagaaa c" /listShort="ylaE" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1458131) /Source="Nicolas_upshifts" /id="D832" /incds=0 /nref=18 /ntot=138 /MaxReadThrough="2.72081" /MaxDrop="5.25382" /score="5.78870736" /energy="-8.3" /TU="NA" /idTUdmin="U1226" /TUdmin="-17" /isTUend="TRUE" /label="downshifts" CDS complement(1458148..1458336) /gene="ylaF" /locus_tag="BSU_14760" /old_locus_tag="BSU14760" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389359.1" /db_xref="EnsemblGenomes-Gn:BSU14760" /db_xref="EnsemblGenomes-Tr:CAB13349" /db_xref="GOA:O07630" /db_xref="InterPro:IPR035211" /db_xref="SubtiList:BG13343" /db_xref="UniProtKB/Swiss-Prot:O07630" /translation="MKKMNWLLLLFAFAAVFSIMLIGVFIAEKSPAGIIASIVLVCAV MGGGFTLKKKMREQGLLD*" /label="ylaF CDS" gene complement(1458148..1458336) /gene="ylaF" /locus_tag="BSU_14760" /old_locus_tag="BSU14760" /label="ylaF gene" downshifts complement(1458202) /Source="Nicolas_upshifts" /id="D833" /incds=0 /nref=9 /ntot=204 /MaxReadThrough="4.38484" /MaxDrop="3.2214" /score="5.78870736" /energy="-8.3" /TU="U1226" /idTUdmin="U1226" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1458358..1458377) /Source="Nicolas_upshift_promotors" /id="U1226" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig=1 /xcortree=3095 /SigmaFactorBS="aaaaaaattagataactttcatattatatcacacatccTCTT TAAAagcgtcacgtttTTCTGTAAACTTAATATAAGacgtaaaaggggatggaattta t" /listShort="ylaF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1458375) /Source="Nicolas_upshifts" /id="U1226" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig=1 /xcortree=3095 /SigmaFactorBS="aaaaaaattagataactttcatattatatcacacatccTCTT TAAAagcgtcacgtttTTCTGTAAACTTAATATAAGacgtaaaaggggatggaattta t" /listShort="ylaF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1458390..1458397) /Source="Nicolas_upshift_promotors" /id="U1226" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig=1 /xcortree=3095 /SigmaFactorBS="aaaaaaattagataactttcatattatatcacacatccTCTT TAAAagcgtcacgtttTTCTGTAAACTTAATATAAGacgtaaaaggggatggaattta t" /listShort="ylaF" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 1458403..1458422 /Source="Nicolas_upshift_promotors" /id="U1227" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2497 /SigmaFactorBS="ttttacgtcttatattaagtttacagaaaaacgtgacgcttt taaagaggatgTGTGATATAATATGAAAGTTatctaatttttttaggagatgaaaaag t" /listShort="bipA, ylaH" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1458410 /Source="Nicolas_upshifts" /id="U1227" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2497 /SigmaFactorBS="ttttacgtcttatattaagtttacagaaaaacgtgacgcttt taaagaggatgTGTGATATAATATGAAAGTTatctaatttttttaggagatgaaaaag t" /listShort="bipA, ylaH" /GFF_Attribute="listLong" /label="upshifts" CDS 1458449..1460287 /gene="bipA" /locus_tag="BSU_14770" /old_locus_tag="BSU14770" /function="16.3: Control" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11683274, 12399512, 9642082, 25135187, 26283392; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosome-associated GTPase" /protein_id="NP_389360.1" /db_xref="EnsemblGenomes-Gn:BSU14770" /db_xref="EnsemblGenomes-Tr:CAB13350" /db_xref="GOA:O07631" /db_xref="InterPro:IPR000640" /db_xref="InterPro:IPR000795" /db_xref="InterPro:IPR004161" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR006298" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031157" /db_xref="InterPro:IPR035647" /db_xref="InterPro:IPR035651" /db_xref="SubtiList:BG13344" /db_xref="UniProtKB/Swiss-Prot:O07631" /translation="MKLRNDLRNIAIIAHVDHGKTTLVDQLLHQAGTFRANEQVAERA MDSNDLERERGITILAKNTAINYKDTRINILDTPGHADFGGEVERIMKMVDGVVLVVD AYEGCMPQTRFVLKKALEQNLNPVVVVNKIDRDFARPEEVIDEVLDLFIELDANEEQL EFPVVYASAINGTASLDPKQQDENMEALYETIIKHVPAPVDNAEEPLQFQVALLDYND YVGRIGIGRVFRGTMKVGQQVSLMKLDGTAKSFRVTKIFGFQGLKRVEIEEAKAGDLV AVSGMEDINVGETVCPVDHQDPLPVLRIDEPTLQMTFVVNNSPFAGREGKYVTARKIE ERLQSQLQTDVSLRVEPTASPDAWVVSGRGELHLSILIENMRREGYELQVSKPEVIIK EIDGVRCEPVERVQIDVPEEHTGSVMESMGARKGEMVDMINNGNGQVRLIFTVPSRGL IGYSTEFLSLTRGFGILNHTFDSYQPMQAGQVGGRRQGVLVSMENGKATSYGIQGIED RGVIFVEPGTEVYEGMIVGEHNRDNDLVVNVSKMKQQTNVRSATKDQTTTIKKARIMS LEESLEYLNEDEYCEVTPESIRLRKKILNKNEREKAAKKKKTAGLS*" /label="bipA CDS" gene 1458449..1460287 /gene="bipA" /locus_tag="BSU_14770" /old_locus_tag="BSU14770" /label="bipA gene" CDS 1460344..1460661 /gene="ylaH" /locus_tag="BSU_14780" /old_locus_tag="BSU14780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unkown function" /protein_id="NP_389361.1" /db_xref="EnsemblGenomes-Gn:BSU14780" /db_xref="EnsemblGenomes-Tr:CAB13351" /db_xref="GOA:O07632" /db_xref="InterPro:IPR025620" /db_xref="SubtiList:BG13345" /db_xref="UniProtKB/Swiss-Prot:O07632" /translation="MNDVSERLSFFAALYQVDRQPAAGMWLLYGTIFVLAVIVFKLGF AKRLPVLKSAVVYVFLALGCTVLTFLGVFLPVAEGLVVAALILIIYKIRLYQSKKGQS AKS*" /label="ylaH CDS" gene 1460344..1460661 /gene="ylaH" /locus_tag="BSU_14780" /old_locus_tag="BSU14780" /label="ylaH gene" downshifts 1460635 /Source="Nicolas_upshifts" /id="D834" /incds=0 /nref=241 /ntot=297 /MaxReadThrough="2.76511" /MaxDrop="7.50514" /score="29.8701447" /energy="-12.5" /TU="NA" /idTUdmin="U1227" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" downshifts complement(1460710) /Source="Nicolas_upshifts" /id="D835" /incds=0 /nref=240 /ntot=265 /MaxReadThrough="0.672690000000001" /MaxDrop="7.03405" /score="10.4340016" /energy="-12.5" /TU="NA" /idTUdmin="U1228" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1460717..1460926) /gene="ylaI" /locus_tag="BSU_14790" /old_locus_tag="BSU14790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389362.1" /db_xref="EnsemblGenomes-Gn:BSU14790" /db_xref="EnsemblGenomes-Tr:CAB13352" /db_xref="InterPro:IPR019241" /db_xref="SubtiList:BG13346" /db_xref="UniProtKB/Swiss-Prot:O07633" /translation="MMRVKCSICDKIETIDDDTLIAKRLRNRPIHTYMCQECHDRIAK KTEERLKTGKFTFHPGQQKKEKVKK*" /label="ylaI CDS" gene complement(1460717..1460926) /gene="ylaI" /locus_tag="BSU_14790" /old_locus_tag="BSU14790" /label="ylaI gene" misc_feature complement(1460940..1460959) /Source="Nicolas_upshift_promotors" /id="U1228" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.742257742257742" /psig=1 /xcortree=1900 /SigmaFactorBS="tgactaagctatagccttgcgctttagctttttcttattttg gacagcttctgatcCGTGGTATAATACATGTTAGtgaaagaggtgatatgatgagggt c" /listShort="ylaI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1460955) /Source="Nicolas_upshifts" /id="U1228" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.742257742257742" /psig=1 /xcortree=1900 /SigmaFactorBS="tgactaagctatagccttgcgctttagctttttcttattttg gacagcttctgatcCGTGGTATAATACATGTTAGtgaaagaggtgatatgatgagggt c" /listShort="ylaI" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1461009..1461638) /gene="ylaJ" /locus_tag="BSU_14800" /old_locus_tag="BSU14800" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 28333204; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative germination lipoprotein" /protein_id="NP_389363.1" /db_xref="EnsemblGenomes-Gn:BSU14800" /db_xref="EnsemblGenomes-Tr:CAB13353" /db_xref="GOA:O07634" /db_xref="InterPro:IPR014247" /db_xref="InterPro:IPR015943" /db_xref="InterPro:IPR019076" /db_xref="SubtiList:BG13347" /db_xref="UniProtKB/Swiss-Prot:O07634" /translation="MRILFIIIQLTLILSACAYQQGKQGQNVEKESTRQQETKPIHVK DTTQETKDNGTRTDIAKHLVSVAEKNPDVKDATAVVLGGYAVVGIDVDDTLDRSKVET IKYSVAQALKNDRYGANAVVIADPDTVSRLREMSREISEGHPVTGILDELAAIVGRVL PEVPNDVIDNEDEPQTKQQNDQLNRKQQQEMEKEQNDQSDHHMKKNNND*" /label="ylaJ CDS" gene complement(1461009..1461638) /gene="ylaJ" /locus_tag="BSU_14800" /old_locus_tag="BSU14800" /label="ylaJ gene" downshifts complement(1461040) /Source="Nicolas_upshifts" /id="D836" /incds=0 /nref=57 /ntot=112 /MaxReadThrough="1.90936" /MaxDrop="5.8475" /score="3.85709048" /energy="-7.2" /TU="NA" /idTUdmin="U1229" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1461540..1461558) /Source="Nicolas_upshift_promotors" /id="U1229" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=545 /SigmaFactorBS="acttatcctgtccgcttgtgcctatcaaCAAGGAAAAcaggg ccagaaTGTTGAAAAAGAATCAACAagacagcaggagactaaaccgattcacgtaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1461546) /Source="Nicolas_upshifts" /id="U1229" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=545 /SigmaFactorBS="acttatcctgtccgcttgtgcctatcaaCAAGGAAAAcaggg ccagaaTGTTGAAAAAGAATCAACAagacagcaggagactaaaccgattcacgtaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1461570..1461578) /Source="Nicolas_upshift_promotors" /id="U1229" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=545 /SigmaFactorBS="acttatcctgtccgcttgtgcctatcaaCAAGGAAAAcaggg ccagaaTGTTGAAAAAGAATCAACAagacagcaggagactaaaccgattcacgtaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1461673..1461684) /Source="Nicolas_upshift_promotors" /id="U1230" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=936 /SigmaFactorBS="aaaggtgaatgcctgctaaaatatatgtttttgTGCATAAag atagaaggttaaTTCAACAATAAAattaatgaaagcattttaaggagggaacccgcaa g" /listShort="ylaJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1461678) /Source="Nicolas_upshifts" /id="U1230" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=936 /SigmaFactorBS="aaaggtgaatgcctgctaaaatatatgtttttgTGCATAAag atagaaggttaaTTCAACAATAAAattaatgaaagcattttaaggagggaacccgcaa g" /listShort="ylaJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1461690..1461695 /Source="Nicolas_upshift_promotors" /id="U1231" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1153 /SigmaFactorBS="tccttaaaatgctttcattaattttattgttgaattaacCTT CTAtctttatgcacaaaaACATATATTTTAGCAGGCAttcacctttttcatcaaaaga g" /listShort="S538, ylaK, S540, glsB" /listLong="ylaN, S541, ftsW, pycA" /label="promotor_-35" promotor_-35 complement(1461699..1461705) /Source="Nicolas_upshift_promotors" /id="U1230" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=936 /SigmaFactorBS="aaaggtgaatgcctgctaaaatatatgtttttgTGCATAAag atagaaggttaaTTCAACAATAAAattaatgaaagcattttaaggagggaacccgcaa g" /listShort="ylaJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1461711..1461729 /Source="Nicolas_upshift_promotors" /id="U1231" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1153 /SigmaFactorBS="tccttaaaatgctttcattaattttattgttgaattaacCTT CTAtctttatgcacaaaaACATATATTTTAGCAGGCAttcacctttttcatcaaaaga g" /listShort="S538, ylaK, S540, glsB" /listLong="ylaN, S541, ftsW, pycA" /label="promotor_-10" upshifts 1461711 /Source="Nicolas_upshifts" /id="U1231" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1153 /SigmaFactorBS="tccttaaaatgctttcattaattttattgttgaattaacCTT CTAtctttatgcacaaaaACATATATTTTAGCAGGCAttcacctttttcatcaaaaga g" /listShort="S538, ylaK, S540, glsB" /listLong="ylaN, S541, ftsW, pycA" /label="upshifts" S_feature 1461712..1461792 /Source="Nicolas_S_feature" /locus_tag="new_1549384_1549464" /HighExp="S3, S5, S4, S8, S6, S7, LoTm, T5.0H, B36, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S538" CDS 1461793..1463121 /gene="ylaK" /locus_tag="BSU_14810" /old_locus_tag="BSU14810" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12762842, 17114254; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative phosphate starvation inducible protein" /protein_id="NP_389364.1" /db_xref="EnsemblGenomes-Gn:BSU14810" /db_xref="EnsemblGenomes-Tr:CAB13354" /db_xref="GOA:O07635" /db_xref="InterPro:IPR002716" /db_xref="InterPro:IPR003714" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR029060" /db_xref="SubtiList:BG13348" /db_xref="UniProtKB/Swiss-Prot:O07635" /translation="MSKIYVLDTNVLLQDPNAIFSFEENEVVIPAVVLEEVDSKKRYM DEVGRNARHVSKLIDALRQKGRLHEHVPLDTGGTLRIELNHRSFHQLQEIFIEKTNDN RILAVAKNLSLEEETKENGRPVILVSKDVLVRVKADAIGLLAEDFLNDRVVDNDEMYS GYKDLYISQQLFSSFYGKNQISVNDVKQHAFYPNQFALMKDELGGSSSAVGIADKTGT VLKRLVFDDEHIWGIRPKNVQQTMALELLLREDIPLVTLIGKAGTGKTLLALAAGLLQ TEDLGIYKKLVVARPIVPVGKDIGYLPGEKEEKLKPWMQPIFDNLEFLFNAKKPGELD AILAGIGSIQVEALTYIRGRSIPDQFIIIDEAQNLTRHEVKTLLTRVGEGSKIVLMGD PEQIDHPYLDSLNNGLAYVVERFKGQPISGSVKLLKGERSGLAQLAADLL*" /label="ylaK CDS" gene 1461793..1463121 /gene="ylaK" /locus_tag="BSU_14810" /old_locus_tag="BSU14810" /label="ylaK gene" S_feature complement(1462977..1463124) /Source="Nicolas_S_feature" /locus_tag="new_1550649_1550796_c" /HighExp="M40t90, M0t90, dia15, Lbtran, dia5, Etha, Mt0, Gly, LBGtran, LPhT" /AntisenseName="ylaK" /AntisenseCor="-0.66426410013570203" /AntisenseRegPval="-34.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S539" downshifts complement(1463020) /Source="Nicolas_upshifts" /id="D837" /incds=1 /nref=6 /ntot=67 /MaxReadThrough="3.81309" /MaxDrop="3.44499" /score="3.85709048" /energy="-7.2" /TU="U1232" /idTUdmin="U1232" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" S_feature 1463122..1463712 /Source="Nicolas_S_feature" /locus_tag="new_1550794_1551384" /HighExp="S3, S4, S6, S5, S8, S7, BT, B36, LoTm, T5.0H" /AntisenseName="ylaL" /AntisenseCor="-0.79954210237955903" /AntisenseRegPval="-60.3" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S540" CDS complement(1463125..1463610) /gene="ylaL" /locus_tag="BSU_14820" /old_locus_tag="BSU14820" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389365.1" /db_xref="EnsemblGenomes-Gn:BSU14820" /db_xref="EnsemblGenomes-Tr:CAB13355" /db_xref="GOA:O07636" /db_xref="InterPro:IPR020229" /db_xref="InterPro:IPR036374" /db_xref="SubtiList:BG13349" /db_xref="UniProtKB/Swiss-Prot:O07636" /translation="MSVIQVKGNVTYPITIDPSVWIFDDRKFSFDRKGDSQDTYLQSA GDESDLDPERVIREGRIAPPTLKTEKQYEKQKLMNGSFAMRLGTVLKNAEPNSSATQC VFVTSSGKAAVSLETALNSIVHFSEAGKPIQEGGPVHIYFEDPVHHKQPITDVKEIEI I*" /label="ylaL CDS" gene complement(1463125..1463610) /gene="ylaL" /locus_tag="BSU_14820" /old_locus_tag="BSU14820" /label="ylaL gene" promotor_-10 complement(1463622..1463641) /Source="Nicolas_upshift_promotors" /id="U1232" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.921078921078921" /psig="0.987012987012987" /xcortree=2208 /SigmaFactorBS="aaacaccctcgttccctcagcatttcaatacacataatttgt acacaAAGTGACAattcatgcgaaaacTTTTATAATTTTGAGAGAAGggggtcatatc a" /listShort="ylaL, S539" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1463650) /Source="Nicolas_upshifts" /id="U1232" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.921078921078921" /psig="0.987012987012987" /xcortree=2208 /SigmaFactorBS="aaacaccctcgttccctcagcatttcaatacacataatttgt acacaAAGTGACAattcatgcgaaaacTTTTATAATTTTGAGAGAAGggggtcatatc a" /listShort="ylaL, S539" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1463656..1463663) /Source="Nicolas_upshift_promotors" /id="U1232" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.921078921078921" /psig="0.987012987012987" /xcortree=2208 /SigmaFactorBS="aaacaccctcgttccctcagcatttcaatacacataatttgt acacaAAGTGACAattcatgcgaaaacTTTTATAATTTTGAGAGAAGggggtcatatc a" /listShort="ylaL, S539" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1463713..1464642 /gene="glsB" /locus_tag="BSU_14830" /old_locus_tag="BSU14830" /EC_number="3.5.1.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:18459799" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18459799; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-glutamine amidohydrolase; glutaminase" /protein_id="NP_389366.1" /db_xref="EnsemblGenomes-Gn:BSU14830" /db_xref="EnsemblGenomes-Tr:CAB13356" /db_xref="GOA:O07637" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR015868" /db_xref="SubtiList:BG13350" /db_xref="UniProtKB/Swiss-Prot:O07637" /translation="MVCQHNDELEALVKKAKKVTDKGEVASYIPALAKADKHDLSVAI YYSNNVCLSAGDVEKTFTLQSISKVLSLALVLMEYGKDKVFSYVGQEPTGDPFNSIIK LETVNPSKPLNPMINAGALVVTSLIRGRTVKERLDYLLSFIRRLTNNQEITYCREVAE SEYSTSMINRAMCYYMKQYGIFEDDVEAVMDLYTKQCAIEMNSLDLAKIGSVFALNGR HPETGEQVISKDVARICKTFMVTCGMYNASGEFAIKVGIPAKSGVSGGIMGISPYDFG IGIFGPALDEKGNSIAGVKLLEIMSEMYRLSIF*" /label="glsB CDS" gene 1463713..1464642 /gene="glsB" /locus_tag="BSU_14830" /old_locus_tag="BSU14830" /label="glsB gene" misc_feature 1464227..1464246 /Source="Nicolas_upshift_promotors" /id="U1233" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.9000999000999" /psig="0.99100899100899" /xcortree=596 /SigmaFactorBS="gccgggaagtggctgaatctgaatacagcacttcaatgatta atcgggcgaTGTGTTATTATATGAAGCAGtacggcatttttgaagatgatgtagaggc a" /GFF_Attribute="listShort" /listLong="ylaN" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1464236 /Source="Nicolas_upshifts" /id="U1233" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.9000999000999" /psig="0.99100899100899" /xcortree=596 /SigmaFactorBS="gccgggaagtggctgaatctgaatacagcacttcaatgatta atcgggcgaTGTGTTATTATATGAAGCAGtacggcatttttgaagatgatgtagaggc a" /GFF_Attribute="listShort" /listLong="ylaN" /label="upshifts" promotor_-35 1464666..1464669 /Source="Nicolas_upshift_promotors" /id="U1234" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig=1 /xcortree=413 /SigmaFactorBS="gtattttttaatttatgtcatatgcttaaatcctCTTGcatt ttctgttgatACCCTTTATGATAAATAGAAgaattaggtactcgcctggggaacggag g" /listShort="ylaN, S541, ftsW, pycA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1464684..1464703 /Source="Nicolas_upshift_promotors" /id="U1234" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig=1 /xcortree=413 /SigmaFactorBS="gtattttttaatttatgtcatatgcttaaatcctCTTGcatt ttctgttgatACCCTTTATGATAAATAGAAgaattaggtactcgcctggggaacggag g" /listShort="ylaN, S541, ftsW, pycA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1464692 /Source="Nicolas_upshifts" /id="U1234" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig=1 /xcortree=413 /SigmaFactorBS="gtattttttaatttatgtcatatgcttaaatcctCTTGcatt ttctgttgatACCCTTTATGATAAATAGAAgaattaggtactcgcctggggaacggag g" /listShort="ylaN, S541, ftsW, pycA" /GFF_Attribute="listLong" /label="upshifts" CDS 1464740..1465021 /gene="ylaN" /locus_tag="BSU_14840" /old_locus_tag="BSU14840" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12682299, 16880555, 17005971,17469204" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389367.1" /db_xref="EnsemblGenomes-Gn:BSU14840" /db_xref="EnsemblGenomes-Tr:CAB13357" /db_xref="InterPro:IPR009983" /db_xref="InterPro:IPR036270" /db_xref="SubtiList:BG13351" /db_xref="UniProtKB/Swiss-Prot:O07638" /translation="MASEMIVDHRQKAFELLKVDAEKILKLIRVQMDNLTMPQCPLYE EVLDTQMFGLSREIDFAVRLGLVDEKDGKDLLYTLERELSALHDAFTAK*" /label="ylaN CDS" gene 1464740..1465021 /gene="ylaN" /locus_tag="BSU_14840" /old_locus_tag="BSU14840" /label="ylaN gene" downshifts 1465010 /Source="Nicolas_upshifts" /id="D838" /incds=0 /nref=72 /ntot=227 /MaxReadThrough="5.3857" /MaxDrop="6.58793" /score="2.26145837" /energy="-6.9" /TU="U1234" /idTUdmin="U1231" /TUdmin=328 /isTUend="FALSE" /label="downshifts" promotor_-35 1465084..1465087 /Source="Nicolas_upshift_promotors" /id="U1235" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.619380619380619" /psig="0.619380619380619" /xcortree=1767 /SigmaFactorBS="attaacagtttgggtttttttataaccgctatttttctctca tcTCATaaaagacggtcttttttTACACATtccttccgaatcgtatagagattcttcg t" /listShort="S541, ftsW, pycA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1465100..1465226 /Source="Nicolas_S_feature" /locus_tag="new_1552772_1552898" /HighExp="S1, T5.0H, T4.0H, HiOs, T3.30H, T3.0H, Etha, Heat, T2.0H, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigI, SigA" /TUshortPSig="0.619, 1" /TUlongSig="SigEF" /TUlongPSig="0.999" /label="S541" upshifts 1465100 /Source="Nicolas_upshifts" /id="U1235" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.619380619380619" /psig="0.619380619380619" /xcortree=1767 /SigmaFactorBS="attaacagtttgggtttttttataaccgctatttttctctca tcTCATaaaagacggtcttttttTACACATtccttccgaatcgtatagagattcttcg t" /listShort="S541, ftsW, pycA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1465105..1465111 /Source="Nicolas_upshift_promotors" /id="U1235" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.619380619380619" /psig="0.619380619380619" /xcortree=1767 /SigmaFactorBS="attaacagtttgggtttttttataaccgctatttttctctca tcTCATaaaagacggtcttttttTACACATtccttccgaatcgtatagagattcttcg t" /listShort="S541, ftsW, pycA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1465227..1466438 /gene="ftsW" /locus_tag="BSU_14850" /old_locus_tag="BSU14850" /function="16.13: Shape" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9622350, 12626683, 15849754, 16850406, 21386816, 27895631" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9622350, 12626683, 15849754, 16850406, 21386816, 27895631; Product type t : transporter" /codon_start=1 /transl_table=11 /product="cell-division protein; transporter of lipid-linked cell wall precursors" /protein_id="NP_389368.1" /db_xref="EnsemblGenomes-Gn:BSU14850" /db_xref="EnsemblGenomes-Tr:CAB13358" /db_xref="GOA:O07639" /db_xref="InterPro:IPR001182" /db_xref="InterPro:IPR018365" /db_xref="SubtiList:BG13352" /db_xref="UniProtKB/Swiss-Prot:O07639" /translation="MLKKMLKSYDYSLIFAIVLLCGFGLVMVYSSSMITAVSRYGVSS NFFFMRQLFALIAGGALFILMALFPYKALAHQKFQKGILLVSVLALISLFVFGHVAGN AQSWFKIGGMSIQPGEFVKLVVILYLAAVYAKKQSYIDHLLTGVAPPVVMTLIICGLI AMQPDFGTAMIIGLIATCMILCSGFSGKTLVRLVILGGIVFILVSPIIYLNQDKILTE GRLARFESLEDPFKYANSSGLQVINSYYAISSGGIFGLGLGESIQKYGYLPESHTDFI MAVIAEELGIFGVLFVIFLLGFVVIKGFYIARKCEDPFGSLLAIGISSMIAIQSFINL GGVSGLIPITGVTLPFISYGGSSLVLLLGSMGILANISMFVKYSENKKKKEPLAPKGM KKKQLKKTVYL*" /label="ftsW CDS" gene 1465227..1466438 /gene="ftsW" /locus_tag="BSU_14850" /old_locus_tag="BSU14850" /label="ftsW gene" promotor_-35 1466448..1466452 /Source="Nicolas_upshift_promotors" /id="U1236" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.320679320679321" /psig="0.98901098901099" /xcortree=2763 /SigmaFactorBS="tgtttatctgtaaaaaacaagtGTGTAcaggggaaggatatT CCGCTATGATAGATTATATtccattcgggtaagggggagaaaagtttgtctcagcaat c" /listShort="pycA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1466467..1466486 /Source="Nicolas_upshift_promotors" /id="U1236" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.320679320679321" /psig="0.98901098901099" /xcortree=2763 /SigmaFactorBS="tgtttatctgtaaaaaacaagtGTGTAcaggggaaggatatT CCGCTATGATAGATTATATtccattcgggtaagggggagaaaagtttgtctcagcaat c" /listShort="pycA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1466486 /Source="Nicolas_upshifts" /id="U1236" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.320679320679321" /psig="0.98901098901099" /xcortree=2763 /SigmaFactorBS="tgtttatctgtaaaaaacaagtGTGTAcaggggaaggatatT CCGCTATGATAGATTATATtccattcgggtaagggggagaaaagtttgtctcagcaat c" /listShort="pycA" /GFF_Attribute="listLong" /label="upshifts" CDS 1466513..1469959 /gene="pycA" /locus_tag="BSU_14860" /old_locus_tag="BSU14860" /EC_number="6.4.1.1" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 6425269, 15134465, 20081037, 20097852; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyruvate carboxylase" /protein_id="NP_389369.1" /db_xref="EnsemblGenomes-Gn:BSU14860" /db_xref="EnsemblGenomes-Tr:CAB13359" /db_xref="GOA:Q9KWU4" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR000891" /db_xref="InterPro:IPR003379" /db_xref="InterPro:IPR005479" /db_xref="InterPro:IPR005481" /db_xref="InterPro:IPR005482" /db_xref="InterPro:IPR005930" /db_xref="InterPro:IPR011053" /db_xref="InterPro:IPR011054" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR011764" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="SubtiList:BG12660" /db_xref="UniProtKB/Swiss-Prot:Q9KWU4" /translation="MSQQSIQKVLVANRGEIAIRIFRACTELNIRTVAVYSKEDSGSY HRYKADEAYLVGEGKKPIDAYLDIEGIIDIAKRNKVDAIHPGYGFLSENIHFARRCEE EGIVFIGPKSEHLDMFGDKVKAREQAEKAGIPVIPGSDGPAETLEAVEQFGQANGYPI IIKASLGGGGRGMRIVRSESEVKEAYERAKSEAKAAFGNDEVYVEKLIENPKHIEVQV IGDKQGNVVHLFERDCSVQRRHQKVIEVAPSVSLSPELRDQICEAAVALAKNVNYINA GTVEFLVANNEFYFIEVNPRVQVEHTITEMITGVDIVQTQILVAQGHSLHSKKVNIPE QKDIFTIGYAIQSRVTTEDPQNDFMPDTGKIMAYRSGGGFGVRLDTGNSFQGAVITPY YDSLLVKLSTWALTFEQAAAKMVRNLQEFRIRGIKTNIPFLENVAKHEKFLTGQYDTS FIDTTPELFNFPKQKDRGTKMLTYIGNVTVNGFPGIGKKEKPAFDKPLGVKVDVDQQP ARGTKQILDEKGAEGLANWVKEQKSVLLTDTTFRDAHQSLLATRIRSHDLKKIANPTA ALWPELFSMEMWGGATFDVAYRFLKEDPWKRLEDLRKEVPNTLFQMLLRSSNAVGYTN YPDNVIKEFVKQSAQSGIDVFRIFDSLNWVKGMTLAIDAVRDTGKVAEAAICYTGDIL DKNRTKYDLAYYTSMAKELEAAGAHILGIKDMAGLLKPQAAYELVSALKETIDIPVHL HTHDTSGNGIYMYAKAVEAGVDIIDVAVSSMAGLTSQPSASGFYHAMEGNDRRPEMNV QGVELLSQYWESVRKYYSEFESGMKSPHTEIYEHEMPGGQYSNLQQQAKGVGLGDRWN EVKEMYRRVNDMFGDIVKVTPSSKVVGDMALYMVQNNLTEKDVYEKGESLDFPDSVVE LFKGNIGQPHGGFPEKLQKLILKGQEPITVRPGELLEPVSFEAIKQEFKEQHNLEISD QDAVAYALYPKVFTDYVKTTESYGDISVLDTPTFFYGMTLGEEIEVEIERGKTLIVKL ISIGEPQPDATRVVYFELNGQPREVVIKDESIKSSVQERLKADRTNPSHIAASMPGTV IKVLAEAGTKVNKGDHLMINEAMKMETTVQAPFSGTIKQVHVKNGEPIQTGDLLLEIE KA*" /label="pycA CDS" gene 1466513..1469959 /gene="pycA" /locus_tag="BSU_14860" /old_locus_tag="BSU14860" /label="pycA gene" promotor_-10 complement(1469525..1469543) /Source="Nicolas_upshift_promotors" /id="U1237" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=1065 /SigmaFactorBS="aatcagcttaacgatcagcgttttgccgcgctcaatttcaaC TTCTAtctcttcacctaatgTCATACCGTAGAAGAATGTcggtgtatctaataccgag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1469545) /Source="Nicolas_upshifts" /id="U1237" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=1065 /SigmaFactorBS="aatcagcttaacgatcagcgttttgccgcgctcaatttcaaC TTCTAtctcttcacctaatgTCATACCGTAGAAGAATGTcggtgtatctaataccgag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1469559..1469564) /Source="Nicolas_upshift_promotors" /id="U1237" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=1065 /SigmaFactorBS="aatcagcttaacgatcagcgttttgccgcgctcaatttcaaC TTCTAtctcttcacctaatgTCATACCGTAGAAGAATGTcggtgtatctaataccgag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1469939 /Source="Nicolas_upshifts" /id="D839" /incds=0 /nref=20 /ntot=213 /MaxReadThrough="5.5667" /MaxDrop="6.03063" /score="0.893081758" /energy="-11.8" /TU="U1236" /idTUdmin="U1234" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" downshifts 1469984 /Source="Nicolas_upshifts" /id="D840" /incds=0 /nref=2 /ntot=51 /MaxReadThrough="4.21552" /MaxDrop="4.9051" /score="0.893081758" /energy="-11.8" /TU="U1236" /idTUdmin="U1234" /TUdmin=44 /isTUend="FALSE" /label="downshifts" downshifts complement(1470016) /Source="Nicolas_upshifts" /id="D841" /incds=0 /nref=2 /ntot=10 /MaxReadThrough="2.24992" /MaxDrop="3.11732" /score="10.1921506" /energy="-11.8" /TU="NA" /idTUdmin="U1238" /TUdmin=330 /isTUend="FALSE" /label="downshifts" downshifts 1470028 /Source="Nicolas_upshifts" /id="D842" /incds=0 /nref=1 /ntot=2 /MaxReadThrough="3.6246" /MaxDrop="4.10361" /score="0.893081758" /energy="-11.8" /TU="U1236" /idTUdmin="U1234" /TUdmin=88 /isTUend="FALSE" /label="downshifts" CDS complement(1470362..1471282) /gene="ctaA" /locus_tag="BSU_14870" /old_locus_tag="BSU14870" /EC_number="1.3.-.-" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:12206660, 15491161, 15849754, 16321940, 16850406, 26592143" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12206660, 15491161, 15849754, 16321940, 16850406, 26592143; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="heme-A synthase" /protein_id="NP_389370.1" /db_xref="EnsemblGenomes-Gn:BSU14870" /db_xref="EnsemblGenomes-Tr:CAB13360" /db_xref="GOA:P12946" /db_xref="InterPro:IPR003780" /db_xref="InterPro:IPR023755" /db_xref="SubtiList:BG10213" /db_xref="UniProtKB/Swiss-Prot:P12946" /translation="MNKALKALGVLTTFVMLIVLIGGALVTKTGSGQGCGRQWPLCHG RFFPELNPASIIEWSHRFASGISIILVLSLAFWSWRKITPIFRETTFLAIMSIIFLFL QALLGALAVVFGSNALIMALHFGISLISFASVLILTLLIFEADKSVRTLVKPLQIGKK MQFHMIGILIYSYIVVYTGAYVRHTESSLACPNVPLCSPLNNGLPTQFHEWVQMGHRA AALLLFVWIIVAAVHAITSYKDQKQIFWGWISCLIFITLQALSGIMIVYSELALGFAL AHSFFIACLFGVLCYFLLLIARFRYESRQS*" /label="ctaA CDS" gene complement(1470362..1471282) /gene="ctaA" /locus_tag="BSU_14870" /old_locus_tag="BSU14870" /label="ctaA gene" downshifts complement(1470368) /Source="Nicolas_upshifts" /id="D843" /incds=0 /nref=126 /ntot=238 /MaxReadThrough="2.72676" /MaxDrop="5.67271" /score="28.8671863" /energy="-15.3" /TU="U1238" /idTUdmin="U1238" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1471322..1471341) /Source="Nicolas_upshift_promotors" /id="U1238" /multdbtbs="SigA,SigE" /comp="M19" /sig="SigA" /pcomp="0.833166833166833" /psig=1 /xcortree=1626 /SigmaFactorBS="cattctattatatttttgtgaacaaaaggctctggGAATTGC CacaaaacacatatTCGCTTACACTTGGAACGTAtataaaattgcagcagtatgttaa g" /listShort="ctaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1471337) /Source="Nicolas_upshifts" /id="U1238" /multdbtbs="SigA,SigE" /comp="M19" /sig="SigA" /pcomp="0.833166833166833" /psig=1 /xcortree=1626 /SigmaFactorBS="cattctattatatttttgtgaacaaaaggctctggGAATTGC CacaaaacacatatTCGCTTACACTTGGAACGTAtataaaattgcagcagtatgttaa g" /listShort="ctaA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1471355..1471362) /Source="Nicolas_upshift_promotors" /id="U1238" /multdbtbs="SigA,SigE" /comp="M19" /sig="SigA" /pcomp="0.833166833166833" /psig=1 /xcortree=1626 /SigmaFactorBS="cattctattatatttttgtgaacaaaaggctctggGAATTGC CacaaaacacatatTCGCTTACACTTGGAACGTAtataaaattgcagcagtatgttaa g" /listShort="ctaA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1471417..1471424 /Source="Nicolas_upshift_promotors" /id="U1239" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.824175824175824" /psig=1 /xcortree=1603 /SigmaFactorBS="acaaaaatataatagaatgacggcttctggaaaatgtaCACT TGATtattcatgccgggTCTGATAGAAATAAGGTAAAcgcaatgccgatttggagatt g" /listShort="S542, S543, ctaB, S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1471438..1471457 /Source="Nicolas_upshift_promotors" /id="U1239" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.824175824175824" /psig=1 /xcortree=1603 /SigmaFactorBS="acaaaaatataatagaatgacggcttctggaaaatgtaCACT TGATtattcatgccgggTCTGATAGAAATAAGGTAAAcgcaatgccgatttggagatt g" /listShort="S542, S543, ctaB, S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1471439..1471544 /Source="Nicolas_S_feature" /locus_tag="new_1559111_1559216" /HighExp="LBGstat, M0t90, Lbstat, BC, T0.30H, T1.30H, B60, M9-stat, M40t90, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S542" upshifts 1471439 /Source="Nicolas_upshifts" /id="U1239" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.824175824175824" /psig=1 /xcortree=1603 /SigmaFactorBS="acaaaaatataatagaatgacggcttctggaaaatgtaCACT TGATtattcatgccgggTCTGATAGAAATAAGGTAAAcgcaatgccgatttggagatt g" /listShort="S542, S543, ctaB, S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="upshifts" S_feature 1471546..1471636 /Source="Nicolas_S_feature" /locus_tag="new_1559218_1559308" /HighExp="LBGstat, M0t90, LPhT, BC, UNK1, BI, Lbexp, LBGtran, Lbstat, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.994, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S543" upshifts 1471546 /Source="Nicolas_upshifts" /id="U1240" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.977022977022977" /psig="0.994005994005994" /xcortree=2711 /SigmaFactorBS="tctttggtaaaattcataaaaagttcacaaataaattcctgt ttgtcgtttaatatttaataggatGTTTttttacaagatgttATCTTGTATGATAGAG T" /listShort="S543, ctaB, S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1471552..1471555 /Source="Nicolas_upshift_promotors" /id="U1240" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.977022977022977" /psig="0.994005994005994" /xcortree=2711 /SigmaFactorBS="tctttggtaaaattcataaaaagttcacaaataaattcctgt ttgtcgtttaatatttaataggatGTTTttttacaagatgttATCTTGTATGATAGAG T" /listShort="S543, ctaB, S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1471570..1471586 /Source="Nicolas_upshift_promotors" /id="U1240" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.977022977022977" /psig="0.994005994005994" /xcortree=2711 /SigmaFactorBS="tctttggtaaaattcataaaaagttcacaaataaattcctgt ttgtcgtttaatatttaataggatGTTTttttacaagatgttATCTTGTATGATAGAG T" /listShort="S543, ctaB, S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1471637..1472554 /gene="ctaB" /locus_tag="BSU_14880" /old_locus_tag="BSU14880" /EC_number="2.5.1.-" /function="16.10: Respire" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:8082800, 10675592, 15849754, 16850406, 7968515, 9829923, 19204012" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8082800, 10675592, 15849754, 16850406, 7968515, 9829923, 19204012; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protoheme IX farnesyltransferase 2" /protein_id="NP_389371.1" /db_xref="EnsemblGenomes-Gn:BSU14880" /db_xref="EnsemblGenomes-Tr:CAB13361" /db_xref="GOA:P24009" /db_xref="InterPro:IPR000537" /db_xref="InterPro:IPR006369" /db_xref="InterPro:IPR030470" /db_xref="SubtiList:BG10214" /db_xref="UniProtKB/Swiss-Prot:P24009" /translation="MANSRILNDTAIDGQIEETTAWKDFLSLIKIGIVNSNLITTFTG MWLALHISGLSFLGNINTVLLTLIGSSLIIAGSCAINNWYDRDIDHLMERTKVRPTVT GKIQPSQALWSGILLVALGLIMLLMTTVMAAVIGFIGVFTYVVLYTMWTKRRYTINTV VGSVSGAVPPLIGWTAVEGNIGVVAWVLFMILFIWQIPHFLALAIKKTEDYRAANIPM LPVVYGFEVTKRQIIVWVACLMPLPFFLGSLGLPIVILGLLLNIGWLILGLMGFRSKN IMKWATQMFVYSLNYMTIYFVAMVVLTLF*" /label="ctaB CDS" gene 1471637..1472554 /gene="ctaB" /locus_tag="BSU_14880" /old_locus_tag="BSU14880" /label="ctaB gene" downshifts 1472583 /Source="Nicolas_upshifts" /id="D844" /incds=0 /nref=33 /ntot=75 /MaxReadThrough="8.35391" /MaxDrop="5.6457" /score="0.893081758" /energy="-11.8" /TU="U1239,U1240" /idTUdmin="U1236" /TUdmin=1719 /isTUend="FALSE" /label="downshifts" upshifts 1472602 /Source="Nicolas_upshifts" /id="U1241" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.406593406593407" /psig="0.406593406593407" /xcortree=510 /SigmaFactorBS="gacgcttttctaaaaaatagatatgatgcttgttttatcgct tcaaaataaacgatgacaaCTAGTAaatgccgccttgacctcttgtttaatcaggcgg c" /listShort="S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="upshifts" misc_feature 1472603..1472608 /Source="Nicolas_upshift_promotors" /id="U1241" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.406593406593407" /psig="0.406593406593407" /xcortree=510 /SigmaFactorBS="gacgcttttctaaaaaatagatatgatgcttgttttatcgct tcaaaataaacgatgacaaCTAGTAaatgccgccttgacctcttgtttaatcaggcgg c" /listShort="S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-35 1472662..1472667 /Source="Nicolas_upshift_promotors" /id="U1242" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.450549450549451" /psig="0.450549450549451" /xcortree=338 /SigmaFactorBS="ttaatcaggcggctttacttttatacatagatGGCATTttga gtaaaaaaacTCATAATTTAAGAGAAGAGgaaatgtaagtgctttattggtgataggt t" /listShort="S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1472682..1472700 /Source="Nicolas_upshift_promotors" /id="U1242" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.450549450549451" /psig="0.450549450549451" /xcortree=338 /SigmaFactorBS="ttaatcaggcggctttacttttatacatagatGGCATTttga gtaaaaaaacTCATAATTTAAGAGAAGAGgaaatgtaagtgctttattggtgataggt t" /listShort="S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1472690..1472793 /Source="Nicolas_S_feature" /locus_tag="new_1560362_1560465" /HighExp="Lbstat, M0t90, M40t90, T2.30H, T3.30H, T2.0H, T3.0H, T4.0H, T1.30H, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, Sig-, SigA, SigA" /TUshortPSig="0.451, 0.407, 0.994, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S544" upshifts 1472690 /Source="Nicolas_upshifts" /id="U1242" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.450549450549451" /psig="0.450549450549451" /xcortree=338 /SigmaFactorBS="ttaatcaggcggctttacttttatacatagatGGCATTttga gtaaaaaaacTCATAATTTAAGAGAAGAGgaaatgtaagtgctttattggtgataggt t" /listShort="S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="upshifts" CDS 1472794..1473864 /gene="ctaC" /locus_tag="BSU_14890" /old_locus_tag="BSU14890" /EC_number="1.9.3.1" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1685007, 1847686, 9829923, 9882689, 27503613" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1685007, 1847686, 9829923, 9882689, 27503613; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome caa3 oxidase (subunit II)" /protein_id="NP_389372.1" /db_xref="EnsemblGenomes-Gn:BSU14890" /db_xref="EnsemblGenomes-Tr:CAB13362" /db_xref="GOA:P24011" /db_xref="InterPro:IPR001505" /db_xref="InterPro:IPR002429" /db_xref="InterPro:IPR008972" /db_xref="InterPro:IPR009056" /db_xref="InterPro:IPR011759" /db_xref="InterPro:IPR014222" /db_xref="InterPro:IPR034236" /db_xref="InterPro:IPR036257" /db_xref="InterPro:IPR036909" /db_xref="SubtiList:BG10215" /db_xref="UniProtKB/Swiss-Prot:P24011" /translation="MVKHWRLILLLALVPLLLSGCGKPFLSTLKPAGEVADKQYDLTV LSTLIMVVVVAVVSVIFFYVIVRFRRSRVGENTIPKQVEGNKFLEITWTVIPILLLII LVIPVVLYTLELADTSPMDKKGRKAEDALVVNVRANLYWWEFEYPDYGIITSQELIVP TDQRVYFNLKASDVKHSFWIPSVGGKLDTNTDNENKFFLTFDSKRSKEAGDMFFGKCA ELCGPSHALMDFKVKTMSAKEFQGWTKEMKNYKSTAESDLAKQGEELFKEKNCLSCHA VEPNDKRAEAARTAPNLATFGERTKVAGVKEANKENVKAWLKDPDSIKPGNKMTGTYP KLSDSETNALYEYLKGLKAESK*" /label="ctaC CDS" gene 1472794..1473864 /gene="ctaC" /locus_tag="BSU_14890" /old_locus_tag="BSU14890" /label="ctaC gene" CDS 1473897..1475765 /gene="ctaD" /locus_tag="BSU_14900" /old_locus_tag="BSU14900" /EC_number="1.9.3.1" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1685007, 1847686, 10675592, 15849754, 16850406, 27503613" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1685007, 1847686, 10675592, 15849754, 16850406, 27503613; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cytochrome caa3 oxidase (subunit I)" /protein_id="NP_389373.2" /db_xref="EnsemblGenomes-Gn:BSU14900" /db_xref="EnsemblGenomes-Tr:CAB13363" /db_xref="GOA:P24010" /db_xref="InterPro:IPR000883" /db_xref="InterPro:IPR014241" /db_xref="InterPro:IPR023615" /db_xref="InterPro:IPR023616" /db_xref="InterPro:IPR036927" /db_xref="SubtiList:BG10216" /db_xref="UniProtKB/Swiss-Prot:P24010" /translation="MLNALTEKRTRGSMLWDYLTTVDHKKIAILYLVAGGFFFLVGGI EAMFIRIQLAKPENAFLSAQAYNEVMTMHGTTMIFLAAMPLLFALMNAVVPLQIGARD VSFPFLNALGFWLFFFGGIFLNLSWFLGGAPDAGWTSYASLSLHSKGHGIDFFVLGLQ ISGLGTLIAGINFLATIINMRAPGMTYMRLPLFTWTTFVASALILFAFPPLTVGLALM MLDRLFGTNFFNPELGGNTVIWEHLFWIFGHPEVYILILPAFGIFSEVIPVFARKRLF GYSSMVFAIVLIGFLGFMVWVHHMFTTGLGPIANAIFAVATMAIAIPTGIKIFNWLLT IWGGNVKYTTAMLYAVSFIPSFVLGGVTGVMLAAAAADYQFHDTYFVVAHFHYVIIGG VVFGLLAGVHFWWPKMFGKILHETMGKISFVLFFIGFHLTFFIQHFVGLMGMPRRVYT FLPGQGLETGNLISTIGAFFMAAAVILLLVNVIWTSVKGEYVGADPWHDGRTLEWTVS SPPPEYNFKQLPFVRGLDPLWIEKQAGHKSMTPAEPVDDIHMPNGSILPLIISFGLFV AAFGLLYRSDYAWGLPVIFIGLGITFITMLLRSVIDDHGYHIHKEELPNDDKGVKA*" /label="ctaD CDS" gene 1473897..1475765 /gene="ctaD" /locus_tag="BSU_14900" /old_locus_tag="BSU14900" /label="ctaD gene" CDS 1475765..1476388 /gene="ctaE" /locus_tag="BSU_14910" /old_locus_tag="BSU14910" /EC_number="1.9.3.1" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1685007, 1847686, 10675592, 15849754, 16850406, 27503613" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1685007, 1847686, 10675592, 15849754, 16850406, 27503613; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cytochrome caa3 oxidase (subunit III)" /protein_id="NP_389374.1" /db_xref="EnsemblGenomes-Gn:BSU14910" /db_xref="EnsemblGenomes-Tr:CAB13364" /db_xref="GOA:P24012" /db_xref="InterPro:IPR000298" /db_xref="InterPro:IPR013833" /db_xref="InterPro:IPR024791" /db_xref="InterPro:IPR033946" /db_xref="InterPro:IPR035973" /db_xref="SubtiList:BG10217" /db_xref="UniProtKB/Swiss-Prot:P24012" /translation="MQVQEKFTAETFPASPEKVTLEGKNKFLGFWLFLGGETVLFASL FATFLALRNSNAGDPPTTEMFDVTLVFIATMLLLTSSLTSVYAMYHMKNFSFGKMQLW LGITILLGAGFLGLEIYEFKHYTHEFGFTITSSALGSAFYTLVGTHGAHVAFGLMWIS TLMIRNAKRGLNLYTAPKFYVASLYWHFIDVVWVFIFTVVYLMGMVG*" /label="ctaE CDS" gene 1475765..1476388 /gene="ctaE" /locus_tag="BSU_14910" /old_locus_tag="BSU14910" /label="ctaE gene" CDS 1476391..1476723 /gene="ctaF" /locus_tag="BSU_14920" /old_locus_tag="BSU14920" /EC_number="1.9.3.1" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1685007, 1847686, 10675592, 15849754, 16850406, 27503613" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1685007, 1847686, 10675592, 15849754, 16850406, 27503613; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cytochrome caa3 oxidase (subunit IV)" /protein_id="NP_389375.1" /db_xref="EnsemblGenomes-Gn:BSU14920" /db_xref="EnsemblGenomes-Tr:CAB13365" /db_xref="GOA:P24013" /db_xref="InterPro:IPR005171" /db_xref="InterPro:IPR014257" /db_xref="SubtiList:BG10218" /db_xref="UniProtKB/Swiss-Prot:P24013" /translation="MVDKKSRGHINSDLEFKKKKHAREMKYQVLSFGLMIGLTIVAFL TVATDGVGSWFTIPFIILLAAIQVIFQLYYFMHMNQKGHEAPALFLYSGVFVAFITVL AFVTIIWW*" /label="ctaF CDS" gene 1476391..1476723 /gene="ctaF" /locus_tag="BSU_14920" /old_locus_tag="BSU14920" /label="ctaF gene" CDS 1476750..1477643 /gene="ctaG" /locus_tag="BSU_14930" /old_locus_tag="BSU14930" /function="16.10: Respire" /function="16.13: Shape" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14766920, 15849754, 16305244, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14766920, 15849754, 16305244, 16850406; Product type f: factor" /codon_start=1 /transl_table=11 /product="cytochrome aa(3) assembly factor" /protein_id="NP_389376.1" /db_xref="EnsemblGenomes-Gn:BSU14930" /db_xref="EnsemblGenomes-Tr:CAB13366" /db_xref="GOA:O34329" /db_xref="InterPro:IPR014108" /db_xref="InterPro:IPR019108" /db_xref="SubtiList:BG12579" /db_xref="UniProtKB/Swiss-Prot:O34329" /translation="MNQLEIFGFRAMWSPYLFCILLGITALYLYFYRRMSSKPNRITG KEMVCFLSAMLFLYAAEGSPVDLLGHIMFSAHMVQMAVLYLVVPPLLIAGIPAWLWEK IIFRPSIKPVFSFFTTPLIALLLFNGIFSLYHVPLIFDTVKTDPFYHTLITWLIFVLA FFMWWPLVHKVERLRQLSGLMKLGYIMADGMLLTPACALIMFSGAPLYATYTDPALWA EAMRLCVPADMMGQVPLTGPEMLNTLPLLEDQQLGAVMMKIIQEIVYGTFLAVIFFQW VKKEREKDGQEEPPYIQQTIS*" /label="ctaG CDS" gene 1476750..1477643 /gene="ctaG" /locus_tag="BSU_14930" /old_locus_tag="BSU14930" /label="ctaG gene" downshifts 1477618 /Source="Nicolas_upshifts" /id="D845" /incds=0 /nref=121 /ntot=229 /MaxReadThrough="1.94099" /MaxDrop="5.91271" /score="4.35633365" /energy="-13.3" /TU="NA" /idTUdmin="U1239" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1477675..1478037) /gene="ylbA" /locus_tag="BSU_14940" /old_locus_tag="BSU14940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389377.1" /db_xref="EnsemblGenomes-Gn:BSU14940" /db_xref="EnsemblGenomes-Tr:CAB13367" /db_xref="InterPro:IPR014967" /db_xref="InterPro:IPR036491" /db_xref="SubtiList:BG13353" /db_xref="UniProtKB/Swiss-Prot:O34743" /translation="MLKFTESGLEGVKAELSWLDDLMESKGLIRAGQWDYERVTYDKK FSTIEGTFYLRIQGIAAEGDVGSGRAVIQLMSPLLGKHYYPHGVEYGETEEFPVQVVT KSKALIQDIANMLKTVQM*" /label="ylbA CDS" gene complement(1477675..1478037) /gene="ylbA" /locus_tag="BSU_14940" /old_locus_tag="BSU14940" /label="ylbA gene" downshifts complement(1477694) /Source="Nicolas_upshifts" /id="D846" /incds=0 /nref=217 /ntot=257 /MaxReadThrough="1.00586" /MaxDrop="6.68145" /score="-3.42191479" /energy="-11.2" /TU="NA" /idTUdmin="U1244" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1478030..1478034 /Source="Nicolas_upshift_promotors" /id="U1243" /multdbtbs="SigF" /comp="M15" /sig="Sig-" /pcomp="0.57942057942058" /psig="0.367632367632368" /xcortree=1041 /SigmaFactorBS="cccttcaagtccgctttcagtaaacTTCAAcactgaccCCTC CTTATAAAAAttacctttcctgacaatcatagtatgaaagcgttaaactttcaatgaa t" /listShort="S545, ylbB, ylbC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1478043..1478056 /Source="Nicolas_upshift_promotors" /id="U1243" /multdbtbs="SigF" /comp="M15" /sig="Sig-" /pcomp="0.57942057942058" /psig="0.367632367632368" /xcortree=1041 /SigmaFactorBS="cccttcaagtccgctttcagtaaacTTCAAcactgaccCCTC CTTATAAAAAttacctttcctgacaatcatagtatgaaagcgttaaactttcaatgaa t" /listShort="S545, ylbB, ylbC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1478061..1478080) /Source="Nicolas_upshift_promotors" /id="U1244" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.78921078921079" /psig="0.985014985014985" /xcortree=515 /SigmaFactorBS="aatttttgcatactttcaaaagaagaagattCATTGAAAgtt taacgctttcaTACTATGATTGTCAGGAAAGgtaatttttataaggaggggtcagtgt t" /listShort="ylbA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1478065..1478176 /Source="Nicolas_S_feature" /locus_tag="new_1565737_1565848" /HighExp="S7, S8, S4, S3, S6, S5, T5.0H, T4.0H, BC, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.368" /TUlongSig="NA" /TUlongPSig="NA" /label="S545" upshifts 1478065 /Source="Nicolas_upshifts" /id="U1243" /multdbtbs="SigF" /comp="M15" /sig="Sig-" /pcomp="0.57942057942058" /psig="0.367632367632368" /xcortree=1041 /SigmaFactorBS="cccttcaagtccgctttcagtaaacTTCAAcactgaccCCTC CTTATAAAAAttacctttcctgacaatcatagtatgaaagcgttaaactttcaatgaa t" /listShort="S545, ylbB, ylbC" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1478073) /Source="Nicolas_upshifts" /id="U1244" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.78921078921079" /psig="0.985014985014985" /xcortree=515 /SigmaFactorBS="aatttttgcatactttcaaaagaagaagattCATTGAAAgtt taacgctttcaTACTATGATTGTCAGGAAAGgtaatttttataaggaggggtcagtgt t" /listShort="ylbA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1478095..1478102) /Source="Nicolas_upshift_promotors" /id="U1244" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.78921078921079" /psig="0.985014985014985" /xcortree=515 /SigmaFactorBS="aatttttgcatactttcaaaagaagaagattCATTGAAAgtt taacgctttcaTACTATGATTGTCAGGAAAGgtaatttttataaggaggggtcagtgt t" /listShort="ylbA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1478177..1478623 /gene="ylbB" /locus_tag="BSU_14950" /old_locus_tag="BSU14950" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /function="18.1: Enzymes of unknown specificity" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_389378.2" /db_xref="EnsemblGenomes-Gn:BSU14950" /db_xref="EnsemblGenomes-Tr:CAB13368" /db_xref="InterPro:IPR000644" /db_xref="SubtiList:BG13354" /db_xref="UniProtKB/Swiss-Prot:O34682" /translation="MTKIKDLMTADLQYCTVLDNVYEAAVKMKDANVGAIPVVDEDGE TLVGIVTDRDLVLRGIAIKKPNSQKITDAMTEKPVSVEEDASVDEVLHLMASHQLRRI PVTKNKKLTGIVTLGDLSLSEQTNERAGSALSDISEGDNREEGFFH*" /label="ylbB CDS" gene 1478177..1478623 /gene="ylbB" /locus_tag="BSU_14950" /old_locus_tag="BSU14950" /label="ylbB gene" promotor_-35 1478209..1478216 /Source="Nicolas_upshift_promotors" /id="U1245" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.536463536463537" /psig="0.996003996003996" /xcortree=2165 /SigmaFactorBS="acggatgacaaaaataaaagatctgatgacagccgaCTTGCA ATattgcacggtaTTAGATAATGTATATGAAGCtgcagtaaagatgaaggacgcaaat g" /listShort="ylbC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1478228..1478247 /Source="Nicolas_upshift_promotors" /id="U1245" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.536463536463537" /psig="0.996003996003996" /xcortree=2165 /SigmaFactorBS="acggatgacaaaaataaaagatctgatgacagccgaCTTGCA ATattgcacggtaTTAGATAATGTATATGAAGCtgcagtaaagatgaaggacgcaaat g" /listShort="ylbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1478233 /Source="Nicolas_upshifts" /id="U1245" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.536463536463537" /psig="0.996003996003996" /xcortree=2165 /SigmaFactorBS="acggatgacaaaaataaaagatctgatgacagccgaCTTGCA ATattgcacggtaTTAGATAATGTATATGAAGCtgcagtaaagatgaaggacgcaaat g" /listShort="ylbC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1478632..1478639 /Source="Nicolas_upshift_promotors" /id="U1246" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig="0.731268731268731" /xcortree=141 /SigmaFactorBS="aagaaggcttttttcattaacacataaaTCTTTGACatgtta aataggcTGTATTGTAATGGGATGTAAacaagagattgtgaatcgccacgggggtgat a" /listShort="ylbC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1478653..1478672 /Source="Nicolas_upshift_promotors" /id="U1246" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig="0.731268731268731" /xcortree=141 /SigmaFactorBS="aagaaggcttttttcattaacacataaaTCTTTGACatgtta aataggcTGTATTGTAATGGGATGTAAacaagagattgtgaatcgccacgggggtgat a" /listShort="ylbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1478664 /Source="Nicolas_upshifts" /id="U1246" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig="0.731268731268731" /xcortree=141 /SigmaFactorBS="aagaaggcttttttcattaacacataaaTCTTTGACatgtta aataggcTGTATTGTAATGGGATGTAAacaagagattgtgaatcgccacgggggtgat a" /listShort="ylbC" /GFF_Attribute="listLong" /label="upshifts" CDS 1478707..1479747 /gene="ylbC" /locus_tag="BSU_14960" /old_locus_tag="BSU14960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389379.1" /db_xref="EnsemblGenomes-Gn:BSU14960" /db_xref="EnsemblGenomes-Tr:CAB13369" /db_xref="GOA:O34586" /db_xref="InterPro:IPR014044" /db_xref="InterPro:IPR029410" /db_xref="InterPro:IPR035940" /db_xref="SubtiList:BG13355" /db_xref="UniProtKB/Swiss-Prot:O34586" /translation="MKNILRAMVILLIICGTYVLFIQYGSVPEKKSNDSEPQVSNEEA QSGKRIHMPTSGLLSFMGKHADEVTKKLGEPERIDPSAYDYDWWVYNQGKDQYIQIGV LNNKVVTLFASGNDINAKPFKIGESTGEVFKTTQVAPFVNVEYKGNSYRFEFSEEDIN TRPTVKVGKMYVQLYMDKFEGKLSSIRAFDAQTFVKQRPYEVVYRGELIKPKAVSDEK WKKIQTTSEKQILDLTNVIRVKHGLAKLEWDQPTAEVAFGHSEDMKENNYFSHVSKKY GSLKDRLEEGHVDFQQAGENIAYNYVDGPAAVEGWLNSEGHRKALLNSDYTHLGVGVD RKYYTQNFIKRW*" /label="ylbC CDS" gene 1478707..1479747 /gene="ylbC" /locus_tag="BSU_14960" /old_locus_tag="BSU14960" /label="ylbC gene" promotor_-10 complement(1479670..1479688) /Source="Nicolas_upshift_promotors" /id="U1247" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1068 /SigmaFactorBS="aataaagttttgggtgtaatatttccGGTCTActccgacacc aagatGCGTATAATCTGAATTCAGaagcgcttttcgatggccttcgctattcagccag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1479675) /Source="Nicolas_upshifts" /id="U1247" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1068 /SigmaFactorBS="aataaagttttgggtgtaatatttccGGTCTActccgacacc aagatGCGTATAATCTGAATTCAGaagcgcttttcgatggccttcgctattcagccag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1479704..1479709) /Source="Nicolas_upshift_promotors" /id="U1247" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1068 /SigmaFactorBS="aataaagttttgggtgtaatatttccGGTCTActccgacacc aagatGCGTATAATCTGAATTCAGaagcgcttttcgatggccttcgctattcagccag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1479727 /Source="Nicolas_upshifts" /id="D847" /incds=0 /nref=84 /ntot=252 /MaxReadThrough="1.59604" /MaxDrop="4.17709" /score="-1.16631837" /energy="-8.1" /TU="NA" /idTUdmin="U1243" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" promotor_-35 1479911..1479920 /Source="Nicolas_upshift_promotors" /id="U1248" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1306 /SigmaFactorBS="aaaattcatttgggaatgaatatAGGCGAACACaatgcccga caaaACGATACATTGTAGTAGGTAacgattttcggagggggtgaggattgtggcgaat c" /listShort="ylbD, ylbE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1479934..1479953 /Source="Nicolas_upshift_promotors" /id="U1248" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1306 /SigmaFactorBS="aaaattcatttgggaatgaatatAGGCGAACACaatgcccga caaaACGATACATTGTAGTAGGTAacgattttcggagggggtgaggattgtggcgaat c" /listShort="ylbD, ylbE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1479948 /Source="Nicolas_upshifts" /id="U1248" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1306 /SigmaFactorBS="aaaattcatttgggaatgaatatAGGCGAACACaatgcccga caaaACGATACATTGTAGTAGGTAacgattttcggagggggtgaggattgtggcgaat c" /listShort="ylbD, ylbE" /GFF_Attribute="listLong" /label="upshifts" CDS 1479979..1480377 /gene="ylbD" /locus_tag="BSU_14970" /old_locus_tag="BSU14970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 19775244, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sporulation-related protein (coat)" /protein_id="NP_389380.1" /db_xref="EnsemblGenomes-Gn:BSU14970" /db_xref="EnsemblGenomes-Tr:CAB13370" /db_xref="InterPro:IPR025953" /db_xref="SubtiList:BG13356" /db_xref="UniProtKB/Swiss-Prot:O34880" /translation="MANQHANHSINDFKQFVKKHPKLIKEVRKEQRSWQDVYENWVLF GESDPIWDPYREPEEASEAVPETPQKNDFVSKMVTAVKKMDVNQMNEQINKMSQSISS LQSLLNTFSGSGQKHSQPGSGQHPFSFRKD*" /label="ylbD CDS" gene 1479979..1480377 /gene="ylbD" /locus_tag="BSU_14970" /old_locus_tag="BSU14970" /label="ylbD gene" downshifts complement(1479983) /Source="Nicolas_upshifts" /id="D848" /incds=0 /nref=2 /ntot=11 /MaxReadThrough="2.37349" /MaxDrop="4.0378" /score="40.2648817" /energy="-14.3" /TU="NA" /idTUdmin="U1247" /TUdmin="-374" /isTUend="FALSE" /label="downshifts" CDS 1480393..1480632 /gene="ylbE" /locus_tag="BSU_14980" /old_locus_tag="BSU14980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22882546" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389381.1" /db_xref="EnsemblGenomes-Gn:BSU14980" /db_xref="EnsemblGenomes-Tr:CAB13371" /db_xref="InterPro:IPR025613" /db_xref="SubtiList:BG13357" /db_xref="UniProtKB/Swiss-Prot:O34958" /translation="MRKEVQEYILANEERKRFIREQPIWYRRLSRKPDDLSSFQLEMM NFYEKTIPHRVNQFTNGIQMAQMMMQMFQAMRTKD*" /label="ylbE CDS" gene 1480393..1480632 /gene="ylbE" /locus_tag="BSU_14980" /old_locus_tag="BSU14980" /label="ylbE gene" downshifts 1480611 /Source="Nicolas_upshifts" /id="D849" /incds=0 /nref=3 /ntot=17 /MaxReadThrough="2.09257" /MaxDrop="4.65792" /score="-7.8200921" /energy="-5.1" /TU="NA" /idTUdmin="U1248" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1480699..1480706 /Source="Nicolas_upshift_promotors" /id="U1249" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=2169 /SigmaFactorBS="cggtcataaggttttgttggcggctgcggttaagcatTTTCC AATtggctggtttCATGGTAAACTAACAACTGGaggtgcatgttatgtatgcgacgat g" /listShort="ylbF, ylbG, NA, S548, S549, ylbH, coaD, S550, S552, ylbK, ylbL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1480717..1480736 /Source="Nicolas_upshift_promotors" /id="U1249" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=2169 /SigmaFactorBS="cggtcataaggttttgttggcggctgcggttaagcatTTTCC AATtggctggtttCATGGTAAACTAACAACTGGaggtgcatgttatgtatgcgacgat g" /listShort="ylbF, ylbG, NA, S548, S549, ylbH, coaD, S550, S552, ylbK, ylbL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1480722 /Source="Nicolas_upshifts" /id="U1249" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=2169 /SigmaFactorBS="cggtcataaggttttgttggcggctgcggttaagcatTTTCC AATtggctggtttCATGGTAAACTAACAACTGGaggtgcatgttatgtatgcgacgat g" /listShort="ylbF, ylbG, NA, S548, S549, ylbH, coaD, S550, S552, ylbK, ylbL" /GFF_Attribute="listLong" /label="upshifts" CDS 1480748..1481197 /gene="ricF" /locus_tag="BSU_14990" /old_locus_tag="BSU14990" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10712692, 15175311, 15661000, 23490197, 26434553, 27501195, 28295778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10712692, 15175311, 15661000, 23490197, 26434553, 27501195, 28295778; Product type r: regulator" /codon_start=1 /transl_table=11 /product="subunit of a sporulation, competence and biofilmformation regulatory complex controlling RNase Y (RicAFTcomplex / FAD / two [4Fe-4S]2+)" /protein_id="NP_389382.1" /db_xref="EnsemblGenomes-Gn:BSU14990" /db_xref="EnsemblGenomes-Tr:CAB13372" /db_xref="GOA:O34412" /db_xref="InterPro:IPR010368" /db_xref="InterPro:IPR023378" /db_xref="SubtiList:BG13358" /db_xref="UniProtKB/Swiss-Prot:O34412" /translation="MYATMESVRLQSEAQQLAEMILQSETAENYRNCYKRLQEDEEAG RIIRSFIKIKEQYEDVQRFGKYHPDYREISRKMREIKRELDLNDKVADFKRAENELQS ILDEVSVEIGTAVSEHVKVPTGNPYFDGLSSCGGGCGSGGSCGCKVS*" /label="ricF CDS" gene 1480748..1481197 /gene="ricF" /locus_tag="BSU_14990" /old_locus_tag="BSU14990" /label="ricF gene" downshifts 1481183 /Source="Nicolas_upshifts" /id="D850" /incds=0 /nref=1 /ntot=6 /MaxReadThrough="5.95111" /MaxDrop="2.83" /score="-4.2014677" /energy="-11.5" /TU="U1249" /idTUdmin="U1248" /TUdmin=572 /isTUend="FALSE" /label="downshifts" CDS 1481252..1481524 /gene="ylbG" /locus_tag="BSU_15000" /old_locus_tag="BSU15000" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 10712692, 21532344, 22333191" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389383.1" /db_xref="EnsemblGenomes-Gn:BSU15000" /db_xref="EnsemblGenomes-Tr:CAB13373" /db_xref="GOA:O34658" /db_xref="InterPro:IPR016979" /db_xref="SubtiList:BG13359" /db_xref="UniProtKB/Swiss-Prot:O34658" /translation="MENRRQGMVVYLHSLKQSKMLRKFGNVHYVSKRLKYVVLYCDMD QIEKTMDKIASYSFVKKVEPSYKPFLKLEFESKLDKAKEYDYKIGI*" /label="ylbG CDS" gene 1481252..1481524 /gene="ylbG" /locus_tag="BSU_15000" /old_locus_tag="BSU15000" /label="ylbG gene" S_feature complement(1481329..1481552) /Source="Nicolas_S_feature" /locus_tag="new_1569001_1569224_c" /HighExp="S8, S7, S4, S5, S6, S3, C30, BT, G135, C90" /AntisenseName="ylbG" /AntisenseCor="-0.668594452827031" /AntisenseRegPval="-35.5" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.537" /TUlongSig="NA" /TUlongPSig="NA" /label="S546" misc_RNA 1481527..1481647 /gene="csfG" /locus_tag="BSU_misc_RNA_23" /product="sporulation-specific regulatory RNA" /experiment="publication(s) with functional evidences, PMID:21532344" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21532344; Product type n: RNA" /function="15.7: Sporulation and germination" /label="csfG RNA" gene 1481527..1481647 /gene="csfG" /locus_tag="BSU_misc_RNA_23" /label="csfG gene" S_feature complement(1481554..1481677) /Source="Nicolas_S_feature" /locus_tag="new_1569226_1569349_c" /HighExp="S3, S8, S7, G/S, S4, S5, Pyr, S6, B36, BT" /AntisenseName="NA" /AntisenseCor="-0.69279578575099399" /AntisenseRegPval="-39.1" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.537" /TUlongSig="NA" /TUlongPSig="NA" /label="S547" downshifts complement(1481597) /Source="Nicolas_upshifts" /id="D851" /incds=0 /nref=61 /ntot=131 /MaxReadThrough="3.9368" /MaxDrop="7.78892" /score="40.2648817" /energy="-14.3" /TU="U1250" /idTUdmin="U1250" /TUdmin="-228" /isTUend="FALSE" /label="downshifts" S_feature 1481648..1481753 /Source="Nicolas_S_feature" /locus_tag="new_1569320_1569425" /HighExp="H2O2, Paraq, Oxctl, G180, G135, G150, Cold, C30, Diami, Glucon" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S548" promotor_-10 complement(1481678..1481690) /Source="Nicolas_upshift_promotors" /id="U1250" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.537462537462537" /psig="0.537462537462537" /xcortree=1087 /SigmaFactorBS="ttccaaacaatgaacgctaatcttgataaacaggTGTATAGg cagcatgatccttGTCCATACTATAAgcaacagcatctagaggatgttgttgccaacc g" /listShort="S547, S546" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1481685) /Source="Nicolas_upshifts" /id="U1250" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.537462537462537" /psig="0.537462537462537" /xcortree=1087 /SigmaFactorBS="ttccaaacaatgaacgctaatcttgataaacaggTGTATAGg cagcatgatccttGTCCATACTATAAgcaacagcatctagaggatgttgttgccaacc g" /listShort="S547, S546" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1481705..1481711) /Source="Nicolas_upshift_promotors" /id="U1250" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.537462537462537" /psig="0.537462537462537" /xcortree=1087 /SigmaFactorBS="ttccaaacaatgaacgctaatcttgataaacaggTGTATAGg cagcatgatccttGTCCATACTATAAgcaacagcatctagaggatgttgttgccaacc g" /listShort="S547, S546" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1481734..1481738 /Source="Nicolas_upshift_promotors" /id="U1251" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.807192807192807" /psig=1 /xcortree=2460 /SigmaFactorBS="atcatgctgcctatacacctgtttatcaagattagcgttCAT TGtttggaagaatgcttTATGTTAAGATAGGATTGATttttttctatgtacatagcgg c" /listShort="S549, ylbH, coaD, S550" /listLong="S552, ylbK, ylbL" /label="promotor_-35" promotor_-10 1481754..1481773 /Source="Nicolas_upshift_promotors" /id="U1251" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.807192807192807" /psig=1 /xcortree=2460 /SigmaFactorBS="atcatgctgcctatacacctgtttatcaagattagcgttCAT TGtttggaagaatgcttTATGTTAAGATAGGATTGATttttttctatgtacatagcgg c" /listShort="S549, ylbH, coaD, S550" /listLong="S552, ylbK, ylbL" /label="promotor_-10" S_feature 1481755..1481846 /Source="Nicolas_S_feature" /locus_tag="new_1569427_1569518" /HighExp="H2O2, G135, Oxctl, Paraq, G180, dia0, G150, Lbexp, LBGexp, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S549" upshifts 1481755 /Source="Nicolas_upshifts" /id="U1251" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.807192807192807" /psig=1 /xcortree=2460 /SigmaFactorBS="atcatgctgcctatacacctgtttatcaagattagcgttCAT TGtttggaagaatgcttTATGTTAAGATAGGATTGATttttttctatgtacatagcgg c" /listShort="S549, ylbH, coaD, S550" /listLong="S552, ylbK, ylbL" /label="upshifts" CDS 1481847..1482401 /gene="rsmD" /locus_tag="BSU_15010" /old_locus_tag="BSU15010" /EC_number="2.1.1.171" /function="18.1: Enzymes of unknown specificity" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16014871, 17389639, 22535590, 22649054; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="16S rRNA m2G966 methyltransferase" /protein_id="NP_389384.2" /db_xref="EnsemblGenomes-Gn:BSU15010" /db_xref="EnsemblGenomes-Tr:CAB13374" /db_xref="GOA:O34331" /db_xref="InterPro:IPR004398" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG13360" /db_xref="UniProtKB/Swiss-Prot:O34331" /translation="MRVISGSKKGRSLKAVAGTSTRPTTDKVKESIFNMIGPYFDGGR GLDLFAGSGGLGIEALSRGFEHCIFVDRDFKAIQTVKSNLKTLELTKHAQVYRNDAER ALHAAAKRETGFRGIFLDPPYKEQKLKALLTLIDEYQMLEEDGFIVAEHDREVELPET VGDLVMTRKETYGLTGVAIYKKRG*" /label="rsmD CDS" gene 1481847..1482401 /gene="rsmD" /locus_tag="BSU_15010" /old_locus_tag="BSU15010" /label="rsmD gene" CDS 1482406..1482891 /gene="coaD" /locus_tag="BSU_15020" /old_locus_tag="BSU15020" /EC_number="2.7.7.3" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10480925, 10939241, 16014871, 21912874; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphopantetheine adenylyltransferase" /protein_id="NP_389385.1" /db_xref="EnsemblGenomes-Gn:BSU15020" /db_xref="EnsemblGenomes-Tr:CAB13375" /db_xref="GOA:O34797" /db_xref="InterPro:IPR001980" /db_xref="InterPro:IPR004821" /db_xref="InterPro:IPR014729" /db_xref="PDB:1O6B" /db_xref="SubtiList:BG13361" /db_xref="UniProtKB/Swiss-Prot:O34797" /translation="MASIAVCPGSFDPVTYGHLDIIKRGAHIFEQVYVCVLNNSSKKP LFSVEERCELLREVTKDIPNITVETSQGLLIDYAKRKNAKAILRGLRAVSDFEYEMQG TSVNRVLDESIETFFMMTNNQYSFLSSSIVKEVARYNGSVSEFVPPEVELALQQKFRQ G*" /label="coaD CDS" gene 1482406..1482891 /gene="coaD" /locus_tag="BSU_15020" /old_locus_tag="BSU15020" /label="coaD gene" downshifts 1482858 /Source="Nicolas_upshifts" /id="D852" /incds=0 /nref=26 /ntot=196 /MaxReadThrough="3.45558" /MaxDrop="3.85134" /score="13.7782945" /energy="-7.8" /TU="U1249,U1251" /idTUdmin="U1251" /TUdmin="-1296" /isTUend="FALSE" /label="downshifts" CDS complement(1482902..1484128) /gene="spoVV" /locus_tag="BSU_15030" /old_locus_tag="BSU15030" /function="16.5: Explore" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12662922, 15849754, 16850406, 28945739" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12662922, 15849754, 16850406, 28945739; Product type t: transporter" /codon_start=1 /transl_table=11 /product="dipicolinic acid transporter (to the spore)" /protein_id="NP_389386.1" /db_xref="EnsemblGenomes-Gn:BSU15030" /db_xref="EnsemblGenomes-Tr:CAB13376" /db_xref="GOA:O34765" /db_xref="InterPro:IPR011642" /db_xref="InterPro:IPR014226" /db_xref="SubtiList:BG13362" /db_xref="UniProtKB/Swiss-Prot:O34765" /translation="MNLSKINTLLIASFFLFLTATVISHPQASFEASKTGLSMWWEVV FPSLLPFFILSELLIGFGIVRFVGVLLEPFMRPIFRVPGVGGFVLAMGMASGNPAGAK LTARLRQENQISRVEAERLASFTNSSNPLFIFGAVAVGFFQNASLGILLASAHYLGNL AVGLTMRSYGRKEEQHLRRKKTIPFPSVKDALHALHTARLAEKRPLGKILGDAVTSSV QTLLMVGGFIILFSVFNRLLSVVQLTDVLSVFTKGALTLFQLPTQLDIPLLSGMFEIT LGSKLVSETDVSLLQKAIIVSFILGFSGFSVQAQVAGILSETDIRFKPFFIARLLQGV YAAVFVMLLWKPLYTAWHDPYQYVFKSLNSSDMSTAFINGWNLLVQIGPAVTLCALFT YIIIFSYRLTNGTKKG*" /label="spoVV CDS" gene complement(1482902..1484128) /gene="spoVV" /locus_tag="BSU_15030" /old_locus_tag="BSU15030" /label="spoVV gene" S_feature 1482903..1484177 /Source="Nicolas_S_feature" /locus_tag="new_1570575_1571849" /HighExp="H2O2, G135, Paraq, G150, G180, Oxctl, LBGexp, dia0, dia15, Mt0" /AntisenseName="ylbJ" /AntisenseCor="-0.54237424349391605" /AntisenseRegPval="-21.2" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S550" S_feature complement(1484129..1484230) /Source="Nicolas_S_feature" /locus_tag="new_1571801_1571902_c" /HighExp="LoTm, S3, S4, S5, T5.0H, M9-stat, T4.0H, S6, BT, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S551" promotor_-35 1484152..1484159 /Source="Nicolas_upshift_promotors" /id="U1252" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=1988 /SigmaFactorBS="acaagttcattcttacctccccgatgctaaaaaTGCCCAATg acatgtatatCATGATAAAATAATGTATGAtgtaaaacggccaagcagtacctgtcct c" /listShort="S552, ylbK, ylbL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1484171..1484190 /Source="Nicolas_upshift_promotors" /id="U1252" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=1988 /SigmaFactorBS="acaagttcattcttacctccccgatgctaaaaaTGCCCAATg acatgtatatCATGATAAAATAATGTATGAtgtaaaacggccaagcagtacctgtcct c" /listShort="S552, ylbK, ylbL" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1484179..1484308 /Source="Nicolas_S_feature" /locus_tag="new_1571851_1571980" /HighExp="Etha, dia15, dia5, Diami, H2O2, Lbtran, LBGtran, Paraq, G150, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S552" upshifts 1484179 /Source="Nicolas_upshifts" /id="U1252" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=1988 /SigmaFactorBS="acaagttcattcttacctccccgatgctaaaaaTGCCCAATg acatgtatatCATGATAAAATAATGTATGAtgtaaaacggccaagcagtacctgtcct c" /listShort="S552, ylbK, ylbL" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1484225..1484243) /Source="Nicolas_upshift_promotors" /id="U1253" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=985 /SigmaFactorBS="cctcctgcctgaattccctgtataccgaattctatGGTCTAa actgaacccctatgcTCGTATATTAGTACAAAGAatcaagaggacaggtactgcttgg c" /listShort="S551, ylbJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1484240) /Source="Nicolas_upshifts" /id="U1253" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=985 /SigmaFactorBS="cctcctgcctgaattccctgtataccgaattctatGGTCTAa actgaacccctatgcTCGTATATTAGTACAAAGAatcaagaggacaggtactgcttgg c" /listShort="S551, ylbJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1484260..1484265) /Source="Nicolas_upshift_promotors" /id="U1253" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=985 /SigmaFactorBS="cctcctgcctgaattccctgtataccgaattctatGGTCTAa actgaacccctatgcTCGTATATTAGTACAAAGAatcaagaggacaggtactgcttgg c" /listShort="S551, ylbJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1484309..1485091 /gene="ylbK" /locus_tag="BSU_15040" /old_locus_tag="BSU15040" /EC_number="3.1.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_389387.1" /db_xref="EnsemblGenomes-Gn:BSU15040" /db_xref="EnsemblGenomes-Tr:CAB13377" /db_xref="GOA:O34731" /db_xref="InterPro:IPR001423" /db_xref="InterPro:IPR002641" /db_xref="InterPro:IPR016035" /db_xref="SubtiList:BG13363" /db_xref="UniProtKB/Swiss-Prot:O34731" /translation="MAKPKIGLALGSGGARGLAHLGVLSSLHKHQIEVDMIAGSSMGA LVGSFYAAGHDVATMKKVAKAFKRRLYADYTVPKLGFLKGDRVRQLVHAYTFGKPIEE LQIPLGIVACDLQTGEKIVFRKGSVSDAVRASISIPGIFIPQRLDGRLLVDGAVVDRI PVSVVKDMGADIIIASDVSRVRKTETAVHIFDVIMQSMDILQNELVRHQTIAADIMIR PSLETYSSSSFANIEEMISAGEEATNRMISKIRKEIENWEGS*" /label="ylbK CDS" gene 1484309..1485091 /gene="ylbK" /locus_tag="BSU_15040" /old_locus_tag="BSU15040" /label="ylbK gene" promotor_-35 1484871..1484877 /Source="Nicolas_upshift_promotors" /id="U1254" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=814 /SigmaFactorBS="ttccagggttcgaaaaactgaaacagcagTGCATATttttga tgtgattATGCAAAGTATGgatatactgcaaaatgaattagtgcggcatcaaacaatt g" /listShort="ylbL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1484891..1484902 /Source="Nicolas_upshift_promotors" /id="U1254" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=814 /SigmaFactorBS="ttccagggttcgaaaaactgaaacagcagTGCATATttttga tgtgattATGCAAAGTATGgatatactgcaaaatgaattagtgcggcatcaaacaatt g" /listShort="ylbL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1484902 /Source="Nicolas_upshifts" /id="U1254" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=814 /SigmaFactorBS="ttccagggttcgaaaaactgaaacagcagTGCATATttttga tgtgattATGCAAAGTATGgatatactgcaaaatgaattagtgcggcatcaaacaatt g" /listShort="ylbL" /GFF_Attribute="listLong" /label="upshifts" CDS 1485093..1486118 /gene="ylbL" /locus_tag="BSU_15050" /old_locus_tag="BSU15050" /function="16.11: Scavenge (Catabolism)" /function="18.1: Enzymes of unknown specificity" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative degradative enzyme" /protein_id="NP_389388.2" /db_xref="EnsemblGenomes-Gn:BSU15050" /db_xref="EnsemblGenomes-Tr:CAB13378" /db_xref="GOA:O34470" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR008269" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR027065" /db_xref="InterPro:IPR036034" /db_xref="PDB:2KJP" /db_xref="SubtiList:BG13364" /db_xref="UniProtKB/Swiss-Prot:O34470" /translation="MLRKKHFSWMLVILILIAVLSFIKLPYYITKPGEATELASLIKV EGGYPEKGSLSLMTVKVGPANPFTYVWAKMHPYYEIVPDESIKEEGESDKEYMKRQLQ MMKSSQENAVIAAYQKAGKKVSYSFNGIYASSVVENMPAKGKIEVGDKIISADGKNYQ SAEKLIDYISSKKAGDKVTLKIEREEKEKRVTLTLKQFPDEPDRAGIGVSLYTDRNVK VEPDIDFEIENIGGPSAGLMMSLEIYNQLTKPDETKGYDIAGTGTIDVDGKVGPIGGI DQKVVAADKAGKDIFFAPNQNGASNSDYKNAVKTAKDIDSNMKIVPVDTMQDAIDYLN KLKAKST*" /label="ylbL CDS" gene 1485093..1486118 /gene="ylbL" /locus_tag="BSU_15050" /old_locus_tag="BSU15050" /label="ylbL gene" downshifts 1486002 /Source="Nicolas_upshifts" /id="D853" /incds=1 /nref=59 /ntot=235 /MaxReadThrough="2.38639" /MaxDrop="3.52503" /score="19.0874959" /energy="-11.5" /TU="NA" /idTUdmin="U1249" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1486135..1487382) /gene="ylbM" /locus_tag="BSU_15060" /old_locus_tag="BSU15060" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16014871, 19215769; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative component of the degradosome" /protein_id="NP_389389.1" /db_xref="EnsemblGenomes-Gn:BSU15060" /db_xref="EnsemblGenomes-Tr:CAB13379" /db_xref="InterPro:IPR008513" /db_xref="InterPro:IPR014729" /db_xref="SubtiList:BG13365" /db_xref="UniProtKB/Swiss-Prot:O34513" /translation="MKAVGLVVEYNPFHNGHLYHAQTAKLQTGCDTAVAVMSGHFLQR GEPAVVSKWARTKMALQSGVDLVIELPYLYAVQKADIFARGSVSILNELECEALFFGS ENGDIKPFLETAQLIDEHKHILNDRIKEELKKGASYPAAAAIAFSSILHTESALDLSK PNNILGYQYVTSILTGGYPMKPYTTARISSDYHDADLPEGENHIASATSIRKAMIGQN LEACLRFLPAASARELAAYRKSFGLWHTPESYFSYLKYSLSTVTARELQQVYEVEEGL EHRIIRSIRKSSSYQEFMELLKTKRYTWTRLQRMNTHILTRTKKQDMQKLLDNDKAPY IRLLGMTKKGQAYLSEKKKALSVPLVSKLSSFSHPALDLDVKASRIYSLPIEEPLRTE FDLQEYGHAPIRYDEDEQHFLNV*" /label="ylbM CDS" gene complement(1486135..1487382) /gene="ylbM" /locus_tag="BSU_15060" /old_locus_tag="BSU15060" /label="ylbM gene" downshifts complement(1486162) /Source="Nicolas_upshifts" /id="D854" /incds=0 /nref=8 /ntot=182 /MaxReadThrough="1.58661" /MaxDrop="3.70777" /score="4.49214865" /energy="-11.5" /TU="NA" /idTUdmin="U1257" /TUdmin=775 /isTUend="FALSE" /label="downshifts" promotor_-35 1487299..1487305 /Source="Nicolas_upshift_promotors" /id="U1255" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=892 /SigmaFactorBS="atgtccgctcatgaccgcgacagccgtgtcacatccGGTTTG CagctttgctgtttGGGCATGATAAAggtgaccgttatgaaagggattatattcaacc a" /listShort="S553, ylbN" /listLong="rpmF" /label="promotor_-35" promotor_-10 1487319..1487330 /Source="Nicolas_upshift_promotors" /id="U1255" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=892 /SigmaFactorBS="atgtccgctcatgaccgcgacagccgtgtcacatccGGTTTG CagctttgctgtttGGGCATGATAAAggtgaccgttatgaaagggattatattcaacc a" /listShort="S553, ylbN" /listLong="rpmF" /label="promotor_-10" upshifts 1487323 /Source="Nicolas_upshifts" /id="U1255" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=892 /SigmaFactorBS="atgtccgctcatgaccgcgacagccgtgtcacatccGGTTTG CagctttgctgtttGGGCATGATAAAggtgaccgttatgaaagggattatattcaacc a" /listShort="S553, ylbN" /listLong="rpmF" /label="upshifts" CDS complement(1487379..1487564) /gene="ylzH" /locus_tag="BSU_15069" /old_locus_tag="BSU15069" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein,of unknown function" /protein_id="YP_003097727.1" /db_xref="EnsemblGenomes-Gn:BSU15069" /db_xref="EnsemblGenomes-Tr:CAX52618" /db_xref="UniProtKB/Swiss-Prot:C0H411" /translation="MIIAFKIVFVNIFSLQHNAAIEVSLTAEYAMHTLKTKIRRKSFH LQMYHTFLNIARKAEKI*" /label="ylzH CDS" gene complement(1487379..1487564) /gene="ylzH" /locus_tag="BSU_15069" /old_locus_tag="BSU15069" /label="ylzH gene" promotor_-35 1487397..1487401 /Source="Nicolas_upshift_promotors" /id="U1256" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.872127872127872" /psig=1 /xcortree=2505 /SigmaFactorBS="aatccgacagctttcatattttttccgccttTCTTGctatgt ttaaaaacgTATGGTACATTTGCAAATGAaaactcttacgccttatttttgttttaag t" /listShort="S553, ylbN, rpmF" /listLong="ylbO" /label="promotor_-35" promotor_-10 1487417..1487436 /Source="Nicolas_upshift_promotors" /id="U1256" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.872127872127872" /psig=1 /xcortree=2505 /SigmaFactorBS="aatccgacagctttcatattttttccgccttTCTTGctatgt ttaaaaacgTATGGTACATTTGCAAATGAaaactcttacgccttatttttgttttaag t" /listShort="S553, ylbN, rpmF" /listLong="ylbO" /label="promotor_-10" S_feature 1487426..1487561 /Source="Nicolas_S_feature" /locus_tag="new_1575098_1575233" /HighExp="Cold, LoTm, Diami, Paraq, H2O2, Oxctl, G180, dia5, G135, LBGexp" /AntisenseName="ylzH" /AntisenseCor="-9.1134498265910996E-2" /AntisenseRegPval="-0.9" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF" /TUshortPSig="1, 0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S553" upshifts 1487426 /Source="Nicolas_upshifts" /id="U1256" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.872127872127872" /psig=1 /xcortree=2505 /SigmaFactorBS="aatccgacagctttcatattttttccgccttTCTTGctatgt ttaaaaacgTATGGTACATTTGCAAATGAaaactcttacgccttatttttgttttaag t" /listShort="S553, ylbN, rpmF" /listLong="ylbO" /label="upshifts" promotor_-10 complement(1487455..1487474) /Source="Nicolas_upshift_promotors" /id="U1257" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.502497502497502" /psig="0.988011988011988" /xcortree=2270 /SigmaFactorBS="tctttacagcataatgctgccattgaagtaTCGTTGACagcg gaatatgctATGCATACACTTAAAACAAAaataaggcgtaagagttttcatttgcaaa t" /listShort="ylbM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1487465) /Source="Nicolas_upshifts" /id="U1257" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.502497502497502" /psig="0.988011988011988" /xcortree=2270 /SigmaFactorBS="tctttacagcataatgctgccattgaagtaTCGTTGACagcg gaatatgctATGCATACACTTAAAACAAAaataaggcgtaagagttttcatttgcaaa t" /listShort="ylbM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1487488..1487495) /Source="Nicolas_upshift_promotors" /id="U1257" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.502497502497502" /psig="0.988011988011988" /xcortree=2270 /SigmaFactorBS="tctttacagcataatgctgccattgaagtaTCGTTGACagcg gaatatgctATGCATACACTTAAAACAAAaataaggcgtaagagttttcatttgcaaa t" /listShort="ylbM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1487532..1487539 /Source="Nicolas_upshift_promotors" /id="U1258" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=2657 /SigmaFactorBS="atggcagcattatgctgtaaagaaaaaatATTGACAAaaaca atcttaaaAGCTATAATCATGTTTGTTGctttcctgaggtgatacaaatgaaatggac g" /listShort="ylbN, rpmF, ylbO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1487553..1487572 /Source="Nicolas_upshift_promotors" /id="U1258" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=2657 /SigmaFactorBS="atggcagcattatgctgtaaagaaaaaatATTGACAAaaaca atcttaaaAGCTATAATCATGTTTGTTGctttcctgaggtgatacaaatgaaatggac g" /listShort="ylbN, rpmF, ylbO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1487563 /Source="Nicolas_upshifts" /id="U1258" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=2657 /SigmaFactorBS="atggcagcattatgctgtaaagaaaaaatATTGACAAaaaca atcttaaaAGCTATAATCATGTTTGTTGctttcctgaggtgatacaaatgaaatggac g" /listShort="ylbN, rpmF, ylbO" /GFF_Attribute="listLong" /label="upshifts" CDS 1487592..1488110 /gene="ylbN" /locus_tag="BSU_15070" /old_locus_tag="BSU15070" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11700356, 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389390.1" /db_xref="EnsemblGenomes-Gn:BSU15070" /db_xref="EnsemblGenomes-Tr:CAB13380" /db_xref="InterPro:IPR003772" /db_xref="SubtiList:BG13366" /db_xref="UniProtKB/Swiss-Prot:O34445" /translation="MKWTIYQLHQMPKQSFEFDETVELNELTKLNSDIRRISPVRVKG RADIKSKQVSFDFTISGEMLLPCSRTLVDVPYPFEISTKELFIFHHTDDIEDDDVHIV EDDTIDITPIVKEEILLEIPMQIFCESEQEKGAAPQEGKDWQVISEEDKKNQVDPRLA ALEKLLKQDDES*" /label="ylbN CDS" gene 1487592..1488110 /gene="ylbN" /locus_tag="BSU_15070" /old_locus_tag="BSU15070" /label="ylbN gene" CDS 1488132..1488311 /gene="rpmF" /locus_tag="BSU_15080" /old_locus_tag="BSU15080" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299; Product type f : factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L32" /protein_id="NP_389391.1" /db_xref="EnsemblGenomes-Gn:BSU15080" /db_xref="EnsemblGenomes-Tr:CAB13381" /db_xref="GOA:O34687" /db_xref="InterPro:IPR002677" /db_xref="InterPro:IPR011332" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG12668" /db_xref="UniProtKB/Swiss-Prot:O34687" /translation="MAVPFRRTSKMKKRLRRTHFKLNVPGMTECPSCGEMKLSHRVCK ACGSYNGKDINVKSN*" /label="rpmF CDS" gene 1488132..1488311 /gene="rpmF" /locus_tag="BSU_15080" /old_locus_tag="BSU15080" /label="rpmF gene" downshifts 1488291 /Source="Nicolas_upshifts" /id="D855" /incds=0 /nref=232 /ntot=266 /MaxReadThrough="5.64002" /MaxDrop="7.70407" /score="53.0065581" /energy="-17.1" /TU="U1258" /idTUdmin="U1256" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(1488334) /Source="Nicolas_upshifts" /id="U1259" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.946053946053946" /psig=0 /xcortree=65 /SigmaFactorBS="actatttgcactcacaaattttccgcaagctgacaggaagag aaaaagaaaaaGCGCagggctttcaccctgcgcttttctcattagttactttttacat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(1488338..1488341) /Source="Nicolas_upshift_promotors" /id="U1259" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.946053946053946" /psig=0 /xcortree=65 /SigmaFactorBS="actatttgcactcacaaattttccgcaagctgacaggaagag aaaaagaaaaaGCGCagggctttcaccctgcgcttttctcattagttactttttacat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-35 1488392..1488397 /Source="Nicolas_upshift_promotors" /id="U1260" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1162 /SigmaFactorBS="tcttcctgtcagcttgcggaaaatttgtgagtgcaaatAGTC TAtctaatctattaccgGCATATGTATGAGATAAATaagctgacatggagggagattg a" /listShort="ylbO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1488413..1488431 /Source="Nicolas_upshift_promotors" /id="U1260" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1162 /SigmaFactorBS="tcttcctgtcagcttgcggaaaatttgtgagtgcaaatAGTC TAtctaatctattaccgGCATATGTATGAGATAAATaagctgacatggagggagattg a" /listShort="ylbO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1488414 /Source="Nicolas_upshifts" /id="U1260" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1162 /SigmaFactorBS="tcttcctgtcagcttgcggaaaatttgtgagtgcaaatAGTC TAtctaatctattaccgGCATATGTATGAGATAAATaagctgacatggagggagattg a" /listShort="ylbO" /GFF_Attribute="listLong" /label="upshifts" CDS 1488457..1489038 /gene="gerR" /locus_tag="BSU_15090" /old_locus_tag="BSU15090" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15621419, 20435725" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15621419, 20435725; Product type r: regulator" /codon_start=1 /transl_table=11 /product="DNA-binding regulator" /protein_id="NP_389392.1" /db_xref="EnsemblGenomes-Gn:BSU15090" /db_xref="EnsemblGenomes-Tr:CAB13382" /db_xref="GOA:O34549" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR014243" /db_xref="InterPro:IPR017930" /db_xref="SubtiList:BG13367" /db_xref="UniProtKB/Swiss-Prot:O34549" /translation="MTITRQDAWTQDEDLLLAEVVLRHIREGGTQLSAFEEVGRALTR TAAACGFRWNSYVRKQYQSGIELAKKQRKELRKQIGVHSVNMPNSMKQTASASSEGKR DLSIQDVIQFLEQFKETPSAQEFQLEREKLKEQIQSLQKELEDLRSENQTLRNQLEMT EEDYKALIDIMDRARKMVVSKEDGRMKKAAQET*" /label="gerR CDS" gene 1488457..1489038 /gene="gerR" /locus_tag="BSU_15090" /old_locus_tag="BSU15090" /label="gerR gene" downshifts 1489039 /Source="Nicolas_upshifts" /id="D856" /incds=0 /nref=56 /ntot=139 /MaxReadThrough="2.70626" /MaxDrop="5.6861" /score="-7.71867756" /energy="-12.8" /TU="U1260" /idTUdmin="U1258" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1489095..1489577) /gene="ylbP" /locus_tag="BSU_15100" /old_locus_tag="BSU15100" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_389393.2" /db_xref="EnsemblGenomes-Gn:BSU15100" /db_xref="EnsemblGenomes-Tr:CAB13383" /db_xref="GOA:O34468" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR017274" /db_xref="PDB:2PR1" /db_xref="SubtiList:BG13368" /db_xref="UniProtKB/Swiss-Prot:O34468" /translation="MTKVERLLINYKTLEEFKKFKEYGIQELSMLEELQDNIIENDST SPFYGIYFGDKLVARMSLYQVNGKSNPYFDNRQDYLELWKLEVLPGYQNRGYGRALVE FAKSFKMPIRTNPRMKSAEFWNKMNFKTVKYDMARDKGENPLIWHPDMDREMTPGESA *" /label="ylbP CDS" gene complement(1489095..1489577) /gene="ylbP" /locus_tag="BSU_15100" /old_locus_tag="BSU15100" /label="ylbP gene" downshifts complement(1489114) /Source="Nicolas_upshifts" /id="D857" /incds=0 /nref=90 /ntot=231 /MaxReadThrough="3.90092" /MaxDrop="6.59996" /score="14.5482917" /energy="-14.5" /TU="U1261" /idTUdmin="U1261" /TUdmin="-615" /isTUend="FALSE" /label="downshifts" downshifts 1489567 /Source="Nicolas_upshifts" /id="D858" /incds=0 /nref=1 /ntot=24 /MaxReadThrough="3.3013" /MaxDrop="4.42908" /score="-7.71867756" /energy="-12.8" /TU="NA" /idTUdmin="U1260" /TUdmin=418 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1489600..1489619) /Source="Nicolas_upshift_promotors" /id="U1261" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig=1 /xcortree=358 /SigmaFactorBS="cttctcaaagatcccatgtgcttaaaattaaagtttaaaTAT TTGGAttttttaaataaaGCGTTTACAATATATGTAGAaacaacaaagggggagattt g" /listShort="ylbP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1489619) /Source="Nicolas_upshifts" /id="U1261" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig=1 /xcortree=358 /SigmaFactorBS="cttctcaaagatcccatgtgcttaaaattaaagtttaaaTAT TTGGAttttttaaataaaGCGTTTACAATATATGTAGAaacaacaaagggggagattt g" /listShort="ylbP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1489633..1489640) /Source="Nicolas_upshift_promotors" /id="U1261" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig=1 /xcortree=358 /SigmaFactorBS="cttctcaaagatcccatgtgcttaaaattaaagtttaaaTAT TTGGAttttttaaataaaGCGTTTACAATATATGTAGAaacaacaaagggggagattt g" /listShort="ylbP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1489677..1489683 /Source="Nicolas_upshift_promotors" /id="U1262" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.826173826173826" /psig=1 /xcortree=1857 /SigmaFactorBS="aatatttaaactttaattttaagcacatgggatctttgagAA GTAATttcttcttactTCTGCTATGATAATACGTAAatgctaaattgggtgtgacatc a" /listShort="ylbQ, yllA" /listLong="S554, mraZ, mraW, ftsL, pbpB" /label="promotor_-35" promotor_-10 1489695..1489714 /Source="Nicolas_upshift_promotors" /id="U1262" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.826173826173826" /psig=1 /xcortree=1857 /SigmaFactorBS="aatatttaaactttaattttaagcacatgggatctttgagAA GTAATttcttcttactTCTGCTATGATAATACGTAAatgctaaattgggtgtgacatc a" /listShort="ylbQ, yllA" /listLong="S554, mraZ, mraW, ftsL, pbpB" /label="promotor_-10" upshifts 1489697 /Source="Nicolas_upshifts" /id="U1262" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.826173826173826" /psig=1 /xcortree=1857 /SigmaFactorBS="aatatttaaactttaattttaagcacatgggatctttgagAA GTAATttcttcttactTCTGCTATGATAATACGTAAatgctaaattgggtgtgacatc a" /listShort="ylbQ, yllA" /listLong="S554, mraZ, mraW, ftsL, pbpB" /label="upshifts" CDS 1489737..1490633 /gene="panE" /locus_tag="BSU_15110" /old_locus_tag="BSU15110" /EC_number="1.1.1.169" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1844812, 10736170, 23894131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1844812, 10736170, 23894131; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-dehydropantoate 2-reductase" /protein_id="NP_389394.1" /db_xref="EnsemblGenomes-Gn:BSU15110" /db_xref="EnsemblGenomes-Tr:CAB13384" /db_xref="GOA:O34661" /db_xref="InterPro:IPR003710" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR013332" /db_xref="InterPro:IPR013752" /db_xref="InterPro:IPR036291" /db_xref="PDB:3EGO" /db_xref="SubtiList:BG13369" /db_xref="UniProtKB/Swiss-Prot:O34661" /translation="MKIGIIGGGSVGLLCAYYLSLYHDVTVVTRRQEQAAAIQSEGIR LYKGGEEFRADCSADTSINSDFDLLVVTVKQHQLQSVFSSLERIGKTNILFLQNGMGH IHDLKDWHVGHSIYVGIVEHGAVRKSDTAVDHTGLGAIKWSAFDDAEPDRLNILFQHN HSDFPIYYETDWYRLLTGKLIVNACINPLTALLQVKNGELLTTPAYLAFMKLVFQEAC RILKLENEEKAWERVQAVCGQTKENRSSMLVDVIGGRQTEADAIIGYLLKEASLQGLD AVHLEFLYGSIKALERNTNKVF*" /label="panE CDS" gene 1489737..1490633 /gene="panE" /locus_tag="BSU_15110" /old_locus_tag="BSU15110" /label="panE gene" CDS 1490704..1492323 /gene="bshC" /locus_tag="BSU_15120" /old_locus_tag="BSU15120" /EC_number="6.-.-.-" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16169927, 19578333, 20308541, 20799687, 25496067" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16169927, 19578333, 20308541, 20799687, 25496067; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="malate glucosamine cysteine ligase" /protein_id="NP_389395.2" /db_xref="EnsemblGenomes-Gn:BSU15120" /db_xref="EnsemblGenomes-Tr:CAB13385" /db_xref="GOA:P55342" /db_xref="InterPro:IPR011199" /db_xref="PDB:4WBD" /db_xref="SubtiList:BG11424" /db_xref="UniProtKB/Swiss-Prot:P55342" /translation="MQLTELSIKNQNVFVQHYIDGKEEMSSFFDYSIHHKDMWRERLE DLSSRFFAREELAAYLTSYHNKFGSSAMQSAIEKLKDPSSAAVVGGQQAGLLTGPLYT IHKIISIIVLAKQQEKELQVPVIPIFWVAGEDHDLDEINFVHTSEENGPVKKKLPQSY WKKSSAASTSLDQEKCAAWIDDVFAAFEETDHTNTLLDNVKRCLRESVTFTDFFELLI ADLFQEEGLVLLNSGDPGIKKLETAMFQKILRENDELARAVSDQQAFMRQAGYKPIIE SGKEQANLFYEYEDERFLIEKDNGRFVIKELDLGWTRDELHTHMEEHPERFSNNVVTR PLMQEFLIPTLAFIAGPGEINYWGELKQAFAVMGFKMPPVMPRLNITILERHIEKKLA ERNISLQDAIERGTENQRETYFERQIPEEFTAVMDQAKSQIEAIHKTVRQEALKVDQS LEPLLLKNAAFIQDQLQFLERTVMKRIEEKEGYVLKDYERIQNSIKPLLAPQERIWNI MYYLNRYGPKFFTTFKNLPFSFQNQHQVVKL*" /label="bshC CDS" gene 1490704..1492323 /gene="bshC" /locus_tag="BSU_15120" /old_locus_tag="BSU15120" /label="bshC gene" downshifts 1492295 /Source="Nicolas_upshifts" /id="D859" /incds=0 /nref=1 /ntot=16 /MaxReadThrough="3.87099" /MaxDrop="3.76832" /score="34.9463932" /energy="-8.3" /TU="U1262" /idTUdmin="U1262" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" promotor_-35 1492357..1492360 /Source="Nicolas_upshift_promotors" /id="U1263" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.501498501498502" /psig="0.955044955044955" /xcortree=3206 /SigmaFactorBS="aaactttgaaataaagttttaaagaaccctgactagttcagg GTTTttttttatgggtaaACAGTGTAAAATGAAGTTGTggagcgaagtggtgaatagt g" /listShort="S554, mraZ, mraW, ftsL, pbpB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1492375..1492448 /Source="Nicolas_S_feature" /locus_tag="new_1580047_1580120" /HighExp="M9-stat, T5.0H, T3.0H, Lbstat, Lbtran, T2.30H, T1.30H, M0t90, T1.0H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.955" /TUlongSig="SigA" /TUlongPSig=1 /label="S554" promotor_-10 1492375..1492394 /Source="Nicolas_upshift_promotors" /id="U1263" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.501498501498502" /psig="0.955044955044955" /xcortree=3206 /SigmaFactorBS="aaactttgaaataaagttttaaagaaccctgactagttcagg GTTTttttttatgggtaaACAGTGTAAAATGAAGTTGTggagcgaagtggtgaatagt g" /listShort="S554, mraZ, mraW, ftsL, pbpB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1492375 /Source="Nicolas_upshifts" /id="U1263" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.501498501498502" /psig="0.955044955044955" /xcortree=3206 /SigmaFactorBS="aaactttgaaataaagttttaaagaaccctgactagttcagg GTTTttttttatgggtaaACAGTGTAAAATGAAGTTGTggagcgaagtggtgaatagt g" /listShort="S554, mraZ, mraW, ftsL, pbpB" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(1492432) /Source="Nicolas_upshifts" /id="D860" /incds=0 /nref=17 /ntot=137 /MaxReadThrough="3.30554" /MaxDrop="4.47473" /score="-9.92306593" /energy="-12" /TU="NA" /idTUdmin="U1264" /TUdmin=1149 /isTUend="FALSE" /label="downshifts" CDS 1492449..1492880 /gene="mraZ" /locus_tag="BSU_15130" /old_locus_tag="BSU15130" /function="16.13: Shape" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10572301, 15939023, 16511046, 24659771, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="inhibitor of RsmH and transcriptional regulator" /protein_id="NP_389396.1" /db_xref="EnsemblGenomes-Gn:BSU15130" /db_xref="EnsemblGenomes-Tr:CAB13386" /db_xref="GOA:P55343" /db_xref="InterPro:IPR003444" /db_xref="InterPro:IPR007159" /db_xref="InterPro:IPR020603" /db_xref="InterPro:IPR035642" /db_xref="InterPro:IPR035644" /db_xref="SubtiList:BG11425" /db_xref="UniProtKB/Swiss-Prot:P55343" /translation="MFMGEYQHTIDAKGRMIVPAKFREGLGEQFVLTRGLDQCLFGYP MHEWKQIEEKLKALPLTKKDARAFTRFFFSGATECELDKQGRVNIASSLLNYAKLEKE CVVIGVSNRIELWSKVIWEQYTEEQEDSFAEIAENMIGFDI*" /label="mraZ CDS" gene 1492449..1492880 /gene="mraZ" /locus_tag="BSU_15130" /old_locus_tag="BSU15130" /label="mraZ gene" CDS 1492950..1493885 /gene="rsmH" /locus_tag="BSU_15140" /old_locus_tag="BSU15140" /EC_number="2.1.1.199" /function="16.6: Maintain" /function="16.13: Shape" /function="16.9: Replicate" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9294438, 9721276, 10572301, 16849811, 19965768, 20924196, 22561317, 27711192; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="16S rRNA m4C1402 methyltransferase" /protein_id="NP_389397.1" /db_xref="EnsemblGenomes-Gn:BSU15140" /db_xref="EnsemblGenomes-Tr:CAB13387" /db_xref="GOA:Q07876" /db_xref="InterPro:IPR002903" /db_xref="InterPro:IPR023397" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG10219" /db_xref="UniProtKB/Swiss-Prot:Q07876" /translation="MFQHKTVLLRETVDGLNIKPDGTYVDCTLGGAGHSTYLLQQLSE KGRLIAFDQDDTALQHAKEVLSDYKGQLILIKSNFRYLKEYLNEQGVTEVDGILFDLG VSSPQLDTPERGFSYHHDAPLDMRMDQSATLSAKEVVNEWRYEDLVRIFFKYGEEKFS KQIARKIEEARMKSPIQTTGQLVDLIKDAIPAPARRSGGHPAKRVFQAIRIAVNDELR VFEEALEQAIEVLKPGGRVSVITFHSLEDRICKTTFKEKSSLPELPPGLPVIPEEFEP ELKLITRKPITASQEELEENNRARSAKLRIAEKRK*" /label="rsmH CDS" gene 1492950..1493885 /gene="rsmH" /locus_tag="BSU_15140" /old_locus_tag="BSU15140" /label="rsmH gene" S_feature complement(1493552..1495004) /Source="Nicolas_S_feature" /locus_tag="new_1581224_1582676_c" /HighExp="Salt, Sw, B60, Etha, M9-stat, Gly, C30, LPhT, BC, B36" /AntisenseName="ftsL" /AntisenseCor="-0.195961042435877" /AntisenseRegPval="-2.9" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S555" CDS 1493925..1494278 /gene="ftsL" /locus_tag="BSU_15150" /old_locus_tag="BSU15150" /function="16.3: Control" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10792716, 10844672, 11994149, 16549676, 16936019, 17020588, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10792716, 10844672, 11994149, 16549676, 16936019, 17020588, 22720735; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell-division protein" /protein_id="NP_389398.1" /db_xref="EnsemblGenomes-Gn:BSU15150" /db_xref="EnsemblGenomes-Tr:CAB13388" /db_xref="GOA:Q07867" /db_xref="InterPro:IPR011922" /db_xref="SubtiList:BG10220" /db_xref="UniProtKB/Swiss-Prot:Q07867" /translation="MSNLAYQPEKQQRHAISPEKKVIVKKRASITLGEKVLLVLFAAA VLSVSLLIVSKAYAAYQTNIEVQKLEEQISSENKQIGDLEKSVADLSKPQRIMDIAKK NGLNLKDKKVKNIQE*" /label="ftsL CDS" gene 1493925..1494278 /gene="ftsL" /locus_tag="BSU_15150" /old_locus_tag="BSU15150" /label="ftsL gene" CDS 1494275..1496425 /gene="pbpB" /locus_tag="BSU_15160" /old_locus_tag="BSU15160" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:8636036, 10411726, 12682299, 14731276" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8636036, 10411726, 12682299, 14731276; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="penicillin-binding protein 2B" /protein_id="NP_389399.2" /db_xref="EnsemblGenomes-Gn:BSU15160" /db_xref="EnsemblGenomes-Tr:CAB13389" /db_xref="GOA:Q07868" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR005311" /db_xref="InterPro:IPR005543" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR036138" /db_xref="SubtiList:BG10221" /db_xref="UniProtKB/Swiss-Prot:Q07868" /translation="MIQMPKKNKFMNRGAAILSICFALFFFVILGRMAYIQITGKANG EVLATKATEQHEKKRTIEASRGSILDRKGKVIAEDTATYKLIAILDKKMTTDVKHPQH VVNKEKTAEALSKVINLDKADILDILNKDAKQVEFGSAGRDITYSQKQKIEKMKLPGI SFLRDTKRYYPNGVFASNLIGYAEVDEETNEISGAMGLEKVLDKYLKERDGYVTYESD KSGWELPNSKNKITAPKNGDNVYLTIDQKIQTFLEDSMTKVAQKYNPKKIMAAVVDPK TGKVLAMGQRPSFDPNKRDVTNYYNDLISYAYEPGSTMKIFTLAAAMQENVFNANEKY KSGTFEVGGAPVKDHNNGVGWGPTTYHDGVLRSSNVAFAKLAKEKLGYDRLNQYLHKF NFYQKTGIDLPGEVSSKINFKYEFDKASTAYGQASAVTPIQQIQAATAIANDGKMMKP YVIDHIVDPDKDKTIYQNKPESAGTPISASTAKKVRDILGEVVTSKIGTGQAYKIEGF DVAGKTGTAQIAGKGGYLDGTDNYIFSFMGMAPKDDPELLIYVAVQQPQLKAGQSSSD PVSEIFNPTMKNSLHYLNIEPTEKSDSDKEETKAQTMPDLTDQTVAAAQKKAKEENLT PIVIGSDVAVKEQYPKADEEVLTNQKVFLKTGGKIKMPDMTGWSRREVLQYGELAGIH IEVSGQGYAVSQSVKKDKEIKDKTVIKVKFKNPD*" /label="pbpB CDS" gene 1494275..1496425 /gene="pbpB" /locus_tag="BSU_15160" /old_locus_tag="BSU15160" /label="pbpB gene" promotor_-10 complement(1494985..1495003) /Source="Nicolas_upshift_promotors" /id="U1264" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=233 /SigmaFactorBS="tatacttttgcgccacttttgtcatgctgtcttccaaaaaGG TTTGAattttctggtcaatGGTTAAATATACATTGTCAccattttttggcgctgtaat t" /listShort="S555" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1495004) /Source="Nicolas_upshifts" /id="U1264" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=233 /SigmaFactorBS="tatacttttgcgccacttttgtcatgctgtcttccaaaaaGG TTTGAattttctggtcaatGGTTAAATATACATTGTCAccattttttggcgctgtaat t" /listShort="S555" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1495018..1495024) /Source="Nicolas_upshift_promotors" /id="U1264" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=233 /SigmaFactorBS="tatacttttgcgccacttttgtcatgctgtcttccaaaaaGG TTTGAattttctggtcaatGGTTAAATATACATTGTCAccattttttggcgctgtaat t" /listShort="S555" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1496408 /Source="Nicolas_upshifts" /id="D861" /incds=0 /nref=237 /ntot=257 /MaxReadThrough="1.141" /MaxDrop="6.28059" /score="3.41058446" /energy="-7.4" /TU="NA" /idTUdmin="U1263" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 1496480..1496485 /Source="Nicolas_upshift_promotors" /id="U1265" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=993 /SigmaFactorBS="tatgcaggctttctttttttatgccttcagaggagcatcGTT CTAcctgtccaaattcagGCATAAAATGAAACAAGCCtaaataaggagtgaacggtct c" /listShort="spoVD" /listLong="S556, S557, murE, S558, mraY" /label="promotor_-35" promotor_-10 1496501..1496519 /Source="Nicolas_upshift_promotors" /id="U1265" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=993 /SigmaFactorBS="tatgcaggctttctttttttatgccttcagaggagcatcGTT CTAcctgtccaaattcagGCATAAAATGAAACAAGCCtaaataaggagtgaacggtct c" /listShort="spoVD" /listLong="S556, S557, murE, S558, mraY" /label="promotor_-10" upshifts 1496501 /Source="Nicolas_upshifts" /id="U1265" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=993 /SigmaFactorBS="tatgcaggctttctttttttatgccttcagaggagcatcGTT CTAcctgtccaaattcagGCATAAAATGAAACAAGCCtaaataaggagtgaacggtct c" /listShort="spoVD" /listLong="S556, S557, murE, S558, mraY" /label="upshifts" CDS 1496542..1498482 /gene="spoVD" /locus_tag="BSU_15170" /old_locus_tag="BSU15170" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:8244929, 8289242, 9006059, 28383125" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8244929, 8289242, 9006059, 28383125; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="transpeptidase penicillin-binding protein" /protein_id="NP_389400.2" /db_xref="EnsemblGenomes-Gn:BSU15170" /db_xref="EnsemblGenomes-Tr:CAB13390" /db_xref="GOA:Q03524" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR005311" /db_xref="InterPro:IPR005543" /db_xref="InterPro:IPR011927" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR036138" /db_xref="SubtiList:BG10222" /db_xref="UniProtKB/Swiss-Prot:Q03524" /translation="MRVSNVTVRKRLLFVLLFGVIVFLIIDTRLGYVQFVMGEKLTSL AKDSWSRNLPFEPERGEILDRNGVKLATNKSAPTVFVVPRQVQNPMKTSKQLAAVLNM SEEKVYKHVTKKASIEKITPEGRKISNEKAKEIKALDLKGVYVAEDSIRHYPFGSFLS HVLGFAGIDNQGLLGLEAYYDDDLKGEKGSVKFYTDAKGKKMPDEADDYTPPKDGLDM KLTVDSKVQTIMERELDNAEAKYHPDGMIAVAMNPKNGEILGMSSRPDFDPADYQSVD PSVYNRNLPVWSTYEPGSTFKIITLAAALEEQKVNLKRDQFYDKGHAEVDGARLRCWK RGGHGLQTYLEVVQNSCNPGFVELGERLGKEKLFKYIKDFGFGQKTGIDLQGEGTGIL FPLERVGPVEQATTAFGQGVSVTPIQQVAAVSAAVNGGTLYTPYIAKEWIDPVTKKTV KKQSPIAKKQVISEETSKQIRYALESVVAEGTGRNAFVEGYRVGGKTGTAQKVKDGKY LENNHIVSFIGFAPADDPSLVVYVAVDNPKGTIQFGGTVAAPIVGNIMRDSLPELGVK PRKNQIEKKYQWNDTKTIEVPNVVGMSVSDLESLLVNLNVDASGKGSKIVKQSPAAGT KVKEGSKIRVYLTEEDEKEAAD*" /label="spoVD CDS" gene 1496542..1498482 /gene="spoVD" /locus_tag="BSU_15170" /old_locus_tag="BSU15170" /label="spoVD gene" promotor_-35 1498278..1498284 /Source="Nicolas_upshift_promotors" /id="U1266" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.435564435564436" /psig="0.435564435564436" /xcortree=578 /SigmaFactorBS="gaaaaatcaaatcgagaaaaaataccaatggaaCGACACAaa aacaatagaagtTCCGAATGTtgtagggatgtctgtctcagatcttgagtcactattg g" /listShort="S556, S557, murE, S558, mraY, murD, spoVE, S559, murG" /listLong="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ, S561, bpr" /label="promotor_-35" promotor_-10 1498299..1498307 /Source="Nicolas_upshift_promotors" /id="U1266" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.435564435564436" /psig="0.435564435564436" /xcortree=578 /SigmaFactorBS="gaaaaatcaaatcgagaaaaaataccaatggaaCGACACAaa aacaatagaagtTCCGAATGTtgtagggatgtctgtctcagatcttgagtcactattg g" /listShort="S556, S557, murE, S558, mraY, murD, spoVE, S559, murG" /listLong="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ, S561, bpr" /label="promotor_-10" upshifts 1498305 /Source="Nicolas_upshifts" /id="U1266" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.435564435564436" /psig="0.435564435564436" /xcortree=578 /SigmaFactorBS="gaaaaatcaaatcgagaaaaaataccaatggaaCGACACAaa aacaatagaagtTCCGAATGTtgtagggatgtctgtctcagatcttgagtcactattg g" /listShort="S556, S557, murE, S558, mraY, murD, spoVE, S559, murG" /listLong="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ, S561, bpr" /label="upshifts" downshifts 1498455 /Source="Nicolas_upshifts" /id="D862" /incds=0 /nref=19 /ntot=91 /MaxReadThrough="4.23549" /MaxDrop="4.37308" /score="-3.90592085" /energy="-13.6" /TU="U1265,U1266" /idTUdmin="U1265" /TUdmin="-91" /isTUend="FALSE" /label="downshifts" S_feature 1498500..1498567 /Source="Nicolas_S_feature" /locus_tag="new_1586172_1586239" /HighExp="C30, G180, G135, ferm, MG 15, G150, MG 45, MG-0.1, MG 10, MG 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.436" /TUlongSig="SigEF" /TUlongPSig=1 /label="S556" promotor_-35 1498537..1498541 /Source="Nicolas_upshift_promotors" /id="U1267" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=2534 /SigmaFactorBS="gaaaaaatgctgatatctttcaagattaGCTGGatgtatcct tttattTACGCTAAAATATGAACTGTatgcttaaaatcattaccacatcatttgatgt g" /listShort="S557, murE, S558, mraY, murD, spoVE, S559, murG, murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /listLong="S561, bpr" /label="promotor_-35" promotor_-10 1498557..1498576 /Source="Nicolas_upshift_promotors" /id="U1267" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=2534 /SigmaFactorBS="gaaaaaatgctgatatctttcaagattaGCTGGatgtatcct tttattTACGCTAAAATATGAACTGTatgcttaaaatcattaccacatcatttgatgt g" /listShort="S557, murE, S558, mraY, murD, spoVE, S559, murG, murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /listLong="S561, bpr" /label="promotor_-10" S_feature 1498569..1498657 /Source="Nicolas_S_feature" /locus_tag="new_1586241_1586329" /HighExp="G180, G150, LBGexp, Paraq, G135, Oxctl, C30, dia0, Cold, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0.436" /TUlongSig="SigEF" /TUlongPSig=1 /label="S557" upshifts 1498569 /Source="Nicolas_upshifts" /id="U1267" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=2534 /SigmaFactorBS="gaaaaaatgctgatatctttcaagattaGCTGGatgtatcct tttattTACGCTAAAATATGAACTGTatgcttaaaatcattaccacatcatttgatgt g" /listShort="S557, murE, S558, mraY, murD, spoVE, S559, murG, murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /listLong="S561, bpr" /label="upshifts" CDS 1498658..1500142 /gene="murE" /locus_tag="BSU_15180" /old_locus_tag="BSU15180" /EC_number="6.3.2.13" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8436954, 10520745, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylmuramoylalanyl-D-glutamate-2, 6-diaminopimelate ligase" /protein_id="NP_389401.1" /db_xref="EnsemblGenomes-Gn:BSU15180" /db_xref="EnsemblGenomes-Tr:CAB13391" /db_xref="GOA:Q03523" /db_xref="InterPro:IPR000713" /db_xref="InterPro:IPR004101" /db_xref="InterPro:IPR005761" /db_xref="InterPro:IPR013221" /db_xref="InterPro:IPR035911" /db_xref="InterPro:IPR036565" /db_xref="InterPro:IPR036615" /db_xref="SubtiList:BG10223" /db_xref="UniProtKB/Swiss-Prot:Q03523" /translation="MKLTKLLTYLTTEPSVNDSQDPEITSIEMDSREVKKGSLFVCVK GYTVDGHDFAQKAVENGAAAIVAEREVDVNVPVIIVRQSLRALSVLSDAFYGQPTKKL QLIGITGTNGKTSTTHMVDEILKKAGKRTGLIGTMYMKIGDETLPVKNTTPESVTLQK TFKKMNDKHVDTAIMEVSSHALSLGRVHGCDYDIAVFTNLTQDHLDYHKTMDEYRHAK SLLFSQLGGAFNHEHPKRAVLNADDEASAYFEKVTAAHISTYGIKNDADVMAKNISIT AQGTSFDLVTNKGTKHITMSLVGQFNVYNVLAAVATCIAAGIPFEIITEAVEELHGVR GRFELVNQQQEFPVIVDYAHTPDSLENVLETCRDMTEGKLFVVVGCGGDRDKTKRPKM AKIAVELADEPIFTSDNPRSEDPRAILRDMEAGVENAYYHSIANREQAIFFAIANAKK GDVVLIAGKGHETYQQIGNETFDFDDAEVAARAIVELNKNKTNS*" /label="murE CDS" gene 1498658..1500142 /gene="murE" /locus_tag="BSU_15180" /old_locus_tag="BSU15180" /label="murE gene" S_feature 1500143..1500253 /Source="Nicolas_S_feature" /locus_tag="new_1587815_1587925" /HighExp="G180, G135, G150, C30, Oxctl, dia0, LBGexp, MG 25, Paraq, MG-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0.436" /TUlongSig="SigEF" /TUlongPSig=1 /label="S558" CDS 1500254..1501228 /gene="mraY" /locus_tag="BSU_15190" /old_locus_tag="BSU15190" /EC_number="2.7.8.13" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 15131133, 15849754, 16850406, 9592129, 24895118, 26620564, 27312048" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15131133, 15849754, 16850406, 9592129, 24895118, 26620564, 27312048; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phospho-N-acetylmuramoyl-pentapeptide undecaprenyl phosphate (C55P) transferase" /protein_id="NP_389402.2" /db_xref="EnsemblGenomes-Gn:BSU15190" /db_xref="EnsemblGenomes-Tr:CAB13392" /db_xref="GOA:Q03521" /db_xref="InterPro:IPR000715" /db_xref="InterPro:IPR003524" /db_xref="InterPro:IPR018480" /db_xref="SubtiList:BG10224" /db_xref="UniProtKB/Swiss-Prot:Q03521" /translation="MLEQVILFTILMGFLISVLLSPILIPFLRRLKFGQSIREEGPKS HQKKSGTPTMGGVMIILSIIVTTIVMTQKFSEISPEMVLLLFVTLGYGLLGFLDDYIK VVMKRNLGLTSKQKLIGQIIIAVVFYAVYHYYNFATDIRIPGTDLSFDLGWAYFILVL FMLVGGSNAVNLTDGLDGLLSGTAAIAFGAFAILAWNQSQYDVAIFSVAVVGAVLGFL VFNAHPAKVFMGDTGSLALGGAIVTIAILTKLEILLVIIGGVFVIETLSVILQVISFK TTGKRIFKMSPLHHHYELVGWSEWRVVVTFWAAGLLLAVLGIYIEVWL*" /label="mraY CDS" gene 1500254..1501228 /gene="mraY" /locus_tag="BSU_15190" /old_locus_tag="BSU15190" /label="mraY gene" CDS 1501229..1502584 /gene="murD" /locus_tag="BSU_15200" /old_locus_tag="BSU15200" /EC_number="6.3.2.9" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1765076, 9218784, 10966819; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylmuramoylalanyl-D-glutamate ligase" /protein_id="NP_389403.1" /db_xref="EnsemblGenomes-Gn:BSU15200" /db_xref="EnsemblGenomes-Tr:CAB13393" /db_xref="GOA:Q03522" /db_xref="InterPro:IPR004101" /db_xref="InterPro:IPR005762" /db_xref="InterPro:IPR013221" /db_xref="InterPro:IPR036565" /db_xref="InterPro:IPR036615" /db_xref="SubtiList:BG10225" /db_xref="UniProtKB/Swiss-Prot:Q03522" /translation="MENDQFLQKQHFLILGLAKSGYAAASILHEKGIYVAVNDQKPFE ENEPAQKLSEKGIEVVCGEHPVSLFDQHQITILIKNPGIPYENIMVQEAEKRGIPVWT EIELAYYLTSAKFIGITGSNGKTTTTTLIYEMLKADSQKALIAGNIGTVASEVAYHAD GDEWIVTELSSFQLMGTHAFRPEISLILNVFDAHLDYHHTRENYEKAKQKVYLHQTAS DKAIVNQDDETVVRLAEAGKAEIVPFSVSKTLEQGAYVKDSMIMFNGEAILPLEEVVL PGAHNLENILAAIAVVKTAGASNEAVKKVLTSFTGVKHRLQYVTTVNGRKFYNDSKAT NILATSKALSAFDKPVILLAGGLDRGNGFDDLKPYMKHVKAVLTFGQTAPKLEKLGNE LGIQHVKRVDNVEQAVSAAFALSNEGDVILLSPACASWDQFKTFEERGDMFIDAVHML K*" /label="murD CDS" gene 1501229..1502584 /gene="murD" /locus_tag="BSU_15200" /old_locus_tag="BSU15200" /label="murD gene" promotor_-35 1502408..1502413 /Source="Nicolas_upshift_promotors" /id="U1268" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.56943056943057" /psig="0.56943056943057" /xcortree=675 /SigmaFactorBS="caaaactcgagaaactcggcaatgaactgGGAATAcaacatg tcaaacgtGTCGATAATGTTGAACAAGcagtatctgcggcgtttgcgctctcaaatga a" /listShort="spoVE, S559, murG, murB, divIB, ylxW, ylxX, sbp" /listLong="S560, ftsA, ftsZ" /label="promotor_-35" promotor_-10 1502429..1502447 /Source="Nicolas_upshift_promotors" /id="U1268" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.56943056943057" /psig="0.56943056943057" /xcortree=675 /SigmaFactorBS="caaaactcgagaaactcggcaatgaactgGGAATAcaacatg tcaaacgtGTCGATAATGTTGAACAAGcagtatctgcggcgtttgcgctctcaaatga a" /listShort="spoVE, S559, murG, murB, divIB, ylxW, ylxX, sbp" /listLong="S560, ftsA, ftsZ" /label="promotor_-10" upshifts 1502439 /Source="Nicolas_upshifts" /id="U1268" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.56943056943057" /psig="0.56943056943057" /xcortree=675 /SigmaFactorBS="caaaactcgagaaactcggcaatgaactgGGAATAcaacatg tcaaacgtGTCGATAATGTTGAACAAGcagtatctgcggcgtttgcgctctcaaatga a" /listShort="spoVE, S559, murG, murB, divIB, ylxW, ylxX, sbp" /listLong="S560, ftsA, ftsZ" /label="upshifts" CDS 1502645..1503745 /gene="spoVE" /locus_tag="BSU_15210" /old_locus_tag="BSU15210" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:2509435, 9622350, 15849754, 16484183, 16850406, 27312048" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2509435, 9622350, 15849754, 16484183, 16850406, 27312048; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="factor for spore cortex peptidoglycan synthesis (stage V sporulation)" /protein_id="NP_389404.1" /db_xref="EnsemblGenomes-Gn:BSU15210" /db_xref="EnsemblGenomes-Tr:CAB13394" /db_xref="GOA:P07373" /db_xref="InterPro:IPR001182" /db_xref="InterPro:IPR013437" /db_xref="InterPro:IPR013438" /db_xref="InterPro:IPR018365" /db_xref="SubtiList:BG10226" /db_xref="UniProtKB/Swiss-Prot:P07373" /translation="MTTKKTSPDLLLVIITLLLLTIGLIMVYSASAVWADYKFDDSFF FAKRQLLFAGIGVIAMFFIMNVDYWTWRTWSKLLMVICFFLLVLVLIPGVGMVRNGSR SWIGVGAFSIQPSEFMKLAMIAFLAKFLSEKQKNITSFRRGFVPALGIVFSAFLIIMC QPDLGTGTVMVGTCIVMIFVAGARIAHFVFLGLIGLSGFVGLVLSAPYRIKRITSYLN PWEDPLGSGFQIIQSLYAVGPGGLFGMGLGQSRQKFFYLPEPQTDFIFAILSEELGFI GGTLILLLFSVLLWRGIRIALGAPDLYGSFVAVGIISMIAIQVMINIGVVTGLIPVTG ITLPFLSYGGSSLTLMLMAVGVLLNVSRYSRY*" /label="spoVE CDS" gene 1502645..1503745 /gene="spoVE" /locus_tag="BSU_15210" /old_locus_tag="BSU15210" /label="spoVE gene" S_feature 1503746..1503867 /Source="Nicolas_S_feature" /locus_tag="new_1591418_1591539" /HighExp="G180, C30, G135, G150, Oxctl, Paraq, LBGexp, dia0, S3, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA, Sig-" /TUshortPSig="0.569, 1, 0.436" /TUlongSig="NA" /TUlongPSig="NA" /label="S559" CDS 1503868..1504959 /gene="murG" /locus_tag="BSU_15220" /old_locus_tag="BSU15220" /EC_number="2.4.1.227" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9244290, 11042447, 12538870, 12682299, 12813070" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9244290, 11042447, 12538870, 12682299, 12813070; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylglucosamine-N-acetylmuramyl- (pentapeptide)pyrophosphoryl-undecaprenol N-acetylglucosamine transferase" /protein_id="NP_389405.2" /db_xref="EnsemblGenomes-Gn:BSU15220" /db_xref="EnsemblGenomes-Tr:CAB13395" /db_xref="GOA:P37585" /db_xref="InterPro:IPR004276" /db_xref="InterPro:IPR006009" /db_xref="InterPro:IPR007235" /db_xref="SubtiList:BG10227" /db_xref="UniProtKB/Swiss-Prot:P37585" /translation="MRIAISGGGTGGHIYPALAFIKEVQRRHPNVEFLYIGTENGLEK KIVERENIPFRSIEITGFKRKLSFENVKTVMRFLKGVKKSKSYLAEFKPDAVIGTGGY VCGPVVYAAAKMGIPTIVHEQNSLPGITNKFLSKYVNKVAICFEEAKSHFPSEKVVFT GNPRASEVVSIKTGRSLAEFGLSEDKKTVLIFGGSRGAAPINRAVIDMQDVLKTRDYQ VLYITGEVHYEKVMNELKSKGAADNMVTKPFLHQMPEYLKAIDVIVARAGATTIAEIT ALGIPSVLIPSPYVTANHQEVNARSLGQHDAAIVLKETELSGEKLIEALDRIVLNEQT LKEMSERTKSLGVPDAAARLYSVLEELKK*" /label="murG CDS" gene 1503868..1504959 /gene="murG" /locus_tag="BSU_15220" /old_locus_tag="BSU15220" /label="murG gene" promotor_-35 1504348..1504357 /Source="Nicolas_upshift_promotors" /id="U1269" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1645 /SigmaFactorBS="tcacattttcctagcgagaaagttgtatttacgGGAAACCCG AgagcctctgaagTCGTCTCAATAAAGACgggacgatcattggctgaatttgggcttt c" /listShort="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /listLong="S561, bpr" /label="promotor_-35" promotor_-10 1504370..1504385 /Source="Nicolas_upshift_promotors" /id="U1269" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1645 /SigmaFactorBS="tcacattttcctagcgagaaagttgtatttacgGGAAACCCG AgagcctctgaagTCGTCTCAATAAAGACgggacgatcattggctgaatttgggcttt c" /listShort="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /listLong="S561, bpr" /label="promotor_-10" upshifts 1504375 /Source="Nicolas_upshifts" /id="U1269" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1645 /SigmaFactorBS="tcacattttcctagcgagaaagttgtatttacgGGAAACCCG AgagcctctgaagTCGTCTCAATAAAGACgggacgatcattggctgaatttgggcttt c" /listShort="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /listLong="S561, bpr" /label="upshifts" promotor_no_box 1504381..1504481 /Source="Nicolas_upshift_promotors" /id="U1270" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.363636363636364" /psig="0.0739260739260739" /xcortree=271 /SigmaFactorBS="aagacgggacgatcattggctgaatttgggctttctgaagac aaaaaaacggtcttaattttcggcggaagccgaggcgctgcaccgattaaccgcgctg t" /listShort="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 1504441 /Source="Nicolas_upshifts" /id="U1270" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.363636363636364" /psig="0.0739260739260739" /xcortree=271 /SigmaFactorBS="aagacgggacgatcattggctgaatttgggctttctgaagac aaaaaaacggtcttaattttcggcggaagccgaggcgctgcaccgattaaccgcgctg t" /listShort="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /GFF_Attribute="listLong" /label="upshifts" CDS 1504991..1505902 /gene="murB" /locus_tag="BSU_15230" /old_locus_tag="BSU15230" /EC_number="1.3.1.98" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11327854, 12682299, 16484183, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylenolpyruvoylglucosamine reductase" /protein_id="NP_389406.1" /db_xref="EnsemblGenomes-Gn:BSU15230" /db_xref="EnsemblGenomes-Tr:CAB13396" /db_xref="GOA:P18579" /db_xref="InterPro:IPR003170" /db_xref="InterPro:IPR006094" /db_xref="InterPro:IPR011601" /db_xref="InterPro:IPR016166" /db_xref="InterPro:IPR016167" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="InterPro:IPR036635" /db_xref="SubtiList:BG10228" /db_xref="UniProtKB/Swiss-Prot:P18579" /translation="MEKVIQELKEREVGKVLANEPLANHTTMKIGGPADVLVIPSSVD AVKDIMDVIKKYDVKWTVIGRGSNLLVLDEGIRGVVIKLGAGLDHLELEGEQVTVGGG YSVVRLATSLSKKGLSGLEFAAGIPGSVGGAVYMNAGAHGSDMSEILVKAHILFEDGT IEWLTNEQMDFSYRTSVLQKKRPGVCLEAVLQLEQKDKESIVQQMQSNKDYRKNTQPY SSPCAGSIFRNPLPNHAGNLVEKAGLKGYQIGGAKISEMHGNFIVNAGGASAKDVLDL IDHVKKTIREKYEIDMHTEVEIIGGNR*" /label="murB CDS" gene 1504991..1505902 /gene="murB" /locus_tag="BSU_15230" /old_locus_tag="BSU15230" /label="murB gene" downshifts 1505920 /Source="Nicolas_upshifts" /id="D863" /incds=0 /nref=2 /ntot=13 /MaxReadThrough="5.78428" /MaxDrop="2.8642" /score="-7.67573434" /energy="-7.4" /TU="U1267,U1268,U1269,U1270" /idTUdmin="U1266" /TUdmin=1809 /isTUend="FALSE" /label="downshifts" CDS 1506032..1506823 /gene="divIB" /locus_tag="BSU_15240" /old_locus_tag="BSU15240" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10852898, 12682299, 15659156, 16618922, 16936019, 16936026, 20460179, 20870765" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10852898, 12682299, 15659156, 16618922, 16936019, 16936026, 20460179, 20870765; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell-division initiation protein" /protein_id="NP_389407.1" /db_xref="EnsemblGenomes-Gn:BSU15240" /db_xref="EnsemblGenomes-Tr:CAB13397" /db_xref="GOA:P16655" /db_xref="InterPro:IPR005548" /db_xref="InterPro:IPR013685" /db_xref="InterPro:IPR026580" /db_xref="InterPro:IPR034746" /db_xref="SubtiList:BG10229" /db_xref="UniProtKB/Swiss-Prot:P16655" /translation="MNPGQDREKIVNIEERIPKIKEQRKQKANRRLISFIMLFFIMVL IIVYLQTPISKVSTISVTGNENVSKKEIIDLSDINSGDTEFWSLDKQKTEKKIQQNKL VKKAEISKSLPNKINIAIEEYKAIAYLEKDDVYYEVLENGSVLPNEVTPDDAGPILVN WTNAKKRSQMAKQLDALSNSLKQSISEIYYTPVKMDENRIKLYMNDGYVVTASIKTFA DRMKTYPSIISQLSSNKKGIIHLEVATYFEEFGKNDKAAKKEDEN*" /label="divIB CDS" gene 1506032..1506823 /gene="divIB" /locus_tag="BSU_15240" /old_locus_tag="BSU15240" /label="divIB gene" CDS 1506820..1507515 /gene="ylxW" /locus_tag="BSU_15250" /old_locus_tag="BSU15250" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16484183" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389408.2" /db_xref="EnsemblGenomes-Gn:BSU15250" /db_xref="EnsemblGenomes-Tr:CAB13398" /db_xref="GOA:C0SPA3" /db_xref="InterPro:IPR010273" /db_xref="SubtiList:BG11490" /db_xref="UniProtKB/Swiss-Prot:C0SPA3" /translation="MRGKSAVLLSLIMLIAGFLISFSFQMTKENNKSAAETEEWKKEY ALRDELLKQEKENKKFEKELYQKQNKVRQAENKLKKEKSEYYNVLEDTEKYRMYIGEV GVQGEGVEVTLEDASYIPEGENVNSYIVHESHIFQVVNELYISGAAAVAVNGQRLTHD SYIKCNGPVVTVDGVQHPAPFTVSAIGDPDVLLPSLNIAGGLIDQLSMDHISVSAEKE KNVQMKPILKTKE*" /label="ylxW CDS" gene 1506820..1507515 /gene="ylxW" /locus_tag="BSU_15250" /old_locus_tag="BSU15250" /label="ylxW gene" CDS 1507538..1508245 /gene="ylxX" /locus_tag="BSU_15260" /old_locus_tag="BSU15260" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16484183, 18179421" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389409.2" /db_xref="EnsemblGenomes-Gn:BSU15260" /db_xref="EnsemblGenomes-Tr:CAB13399" /db_xref="GOA:Q45544" /db_xref="InterPro:IPR010273" /db_xref="SubtiList:BG11489" /db_xref="UniProtKB/Swiss-Prot:Q45544" /translation="MKIKRSFISISVLMVIFGLMISVQFNSLKHPKVRDTRDMWDIRE ELTSEQKKQEKLLAEINKYDKLLNSYSQTKEMTKETALNNTLQSLKKTAGMTDITGSG IVITISPLFSESLTGEPIENPPPDLLKKLINELNSYGAEHISINERRVVNHTVIRDIN GTTKIDGYALDDYPLTVKVLAKDPDMLHSRVKGSGLEDLFASENLALKAGKSESKLTL KAYDRPLDVQQLKLLKD*" /label="ylxX CDS" gene 1507538..1508245 /gene="ylxX" /locus_tag="BSU_15260" /old_locus_tag="BSU15260" /label="ylxX gene" CDS 1508263..1508628 /gene="sbp" /locus_tag="BSU_15270" /old_locus_tag="BSU15270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 1569582, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein (small basic protein)" /protein_id="NP_389410.1" /db_xref="EnsemblGenomes-Gn:BSU15270" /db_xref="EnsemblGenomes-Tr:CAB13400" /db_xref="GOA:P28265" /db_xref="InterPro:IPR009709" /db_xref="SubtiList:BG10230" /db_xref="UniProtKB/Swiss-Prot:P28265" /translation="MWLPVLGLVLGIAIGLMTNLTIPSEYSNYLSLAVLAALDTLIGG IRAHLQGTYDEMVFVSGFFFNIILAISLAFLGVHLGVDLYLAGIFAFGVRLFQNIAVI RRNLLTKWTLSKKNKKNVI*" /label="sbp CDS" gene 1508263..1508628 /gene="sbp" /locus_tag="BSU_15270" /old_locus_tag="BSU15270" /label="sbp gene" promotor_-35 1508480..1508483 /Source="Nicolas_upshift_promotors" /id="U1271" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.474525474525474" /psig="0.98901098901099" /xcortree=2335 /SigmaFactorBS="aatattatattggcaataagtttagCTTTtctgggagtccat ctTGGTGTAGACTTGTATTTAGcaggtatattcgcatttggagtcagattatttcaga a" /listShort="S560, ftsA, ftsZ" /listLong="S561, bpr" /label="promotor_-35" promotor_-10 1508499..1508518 /Source="Nicolas_upshift_promotors" /id="U1271" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.474525474525474" /psig="0.98901098901099" /xcortree=2335 /SigmaFactorBS="aatattatattggcaataagtttagCTTTtctgggagtccat ctTGGTGTAGACTTGTATTTAGcaggtatattcgcatttggagtcagattatttcaga a" /listShort="S560, ftsA, ftsZ" /listLong="S561, bpr" /label="promotor_-10" upshifts 1508515 /Source="Nicolas_upshifts" /id="U1271" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.474525474525474" /psig="0.98901098901099" /xcortree=2335 /SigmaFactorBS="aatattatattggcaataagtttagCTTTtctgggagtccat ctTGGTGTAGACTTGTATTTAGcaggtatattcgcatttggagtcagattatttcaga a" /listShort="S560, ftsA, ftsZ" /listLong="S561, bpr" /label="upshifts" S_feature 1508629..1508801 /Source="Nicolas_S_feature" /locus_tag="new_1596301_1596473" /HighExp="T3.0H, T2.30H, S2, T3.30H, Lbtran, T4.0H, T5.0H, T1.30H, S1, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-, SigWXY, SigA" /TUshortPSig="0.989, 0.0739, 1, 1" /TUlongSig="SigEF, Sig-" /TUlongPSig="0.569, 0.436" /label="S560" CDS 1508802..1510124 /gene="ftsA" /locus_tag="BSU_15280" /old_locus_tag="BSU15280" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 15153768, 16159787, 16796675, 17015652, 23036588, 24224907" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15153768, 16159787, 16796675, 17015652, 23036588, 24224907; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell-division protein essential for Z-ring assembly" /protein_id="NP_389411.2" /db_xref="EnsemblGenomes-Gn:BSU15280" /db_xref="EnsemblGenomes-Tr:CAB13401" /db_xref="GOA:P28264" /db_xref="InterPro:IPR003494" /db_xref="InterPro:IPR020823" /db_xref="SubtiList:BG10231" /db_xref="UniProtKB/Swiss-Prot:P28264" /translation="MNNNELYVSLDIGTSNTKVIVGEMTDDSLNIIGVGNVPSEGLKK GSIVDIDETVHSIRKAFDQAERMVGFPLRKAIVGVNGNYINIQDTNGVVAVSSENKEI QVEDVRRVMEAAQVVSVPHEQLIVDVIPKQFIVDGRDEITDPKKMLGVRLEVEGTLIT GSKTILHNLLRCVERAGIEITDICLQPLAAGSAALSKDEKNLGVALIDIGGGSTTIAV FQNGHLTSTRVIPLGGENITKDISIGLRTSTEEAERVKKQLGHAYYDEASEDEIFEVT VIGTNQKQTFTQQEAANIIEARVEEILEIVSEELRSMGITDLPGGFVLTGGQAAMPGV MSLAQDVLQNNVRVASPNYIGVRDPQYMTGVGLIQFACRNARIQGRKIGFKMPEEAIQ EIAVSSSEEQEQHHHQNEVQQRPKGKQKTQAEHNKQSKMKKLLSMFWE*" /label="ftsA CDS" gene 1508802..1510124 /gene="ftsA" /locus_tag="BSU_15280" /old_locus_tag="BSU15280" /label="ftsA gene" upshifts complement(1509009) /Source="Nicolas_upshifts" /id="U1272" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig="0.001998001998002" /xcortree=70 /SigmaFactorBS="ttgtatcttgaatattgatataatttccattaaCGCCGacaa tagcttttctAAGCGgaaaacctaccattctttcagcttggtcaaacgcttttcttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1509013..1509017) /Source="Nicolas_upshift_promotors" /id="U1272" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig="0.001998001998002" /xcortree=70 /SigmaFactorBS="ttgtatcttgaatattgatataatttccattaaCGCCGacaa tagcttttctAAGCGgaaaacctaccattctttcagcttggtcaaacgcttttcttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1509032..1509036) /Source="Nicolas_upshift_promotors" /id="U1272" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig="0.001998001998002" /xcortree=70 /SigmaFactorBS="ttgtatcttgaatattgatataatttccattaaCGCCGacaa tagcttttctAAGCGgaaaacctaccattctttcagcttggtcaaacgcttttcttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1510160..1511308 /gene="ftsZ" /locus_tag="BSU_15290" /old_locus_tag="BSU15290" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 12950927, 14527275, 15317782, 16159787, 16322744, 16549676, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 12950927, 14527275, 15317782, 16159787, 16322744, 16549676, 22720735; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell-division initiation protein" /protein_id="NP_389412.2" /db_xref="EnsemblGenomes-Gn:BSU15290" /db_xref="EnsemblGenomes-Tr:CAB13402" /db_xref="GOA:P17865" /db_xref="InterPro:IPR000158" /db_xref="InterPro:IPR003008" /db_xref="InterPro:IPR008280" /db_xref="InterPro:IPR018316" /db_xref="InterPro:IPR020805" /db_xref="InterPro:IPR024757" /db_xref="InterPro:IPR036525" /db_xref="InterPro:IPR037103" /db_xref="PDB:2RHH" /db_xref="PDB:2RHJ" /db_xref="PDB:2RHL" /db_xref="PDB:2RHO" /db_xref="PDB:2VAM" /db_xref="PDB:2VXY" /db_xref="PDB:4U39" /db_xref="SubtiList:BG10232" /db_xref="UniProtKB/Swiss-Prot:P17865" /translation="MLEFETNIDGLASIKVIGVGGGGNNAVNRMIENEVQGVEYIAVN TDAQALNLSKAEVKMQIGAKLTRGLGAGANPEVGKKAAEESKEQIEEALKGADMVFVT AGMGGGTGTGAAPVIAQIAKDLGALTVGVVTRPFTFEGRKRQLQAAGGISAMKEAVDT LIVIPNDRILEIVDKNTPMLEAFREADNVLRQGVQGISDLIATPGLINLDFADVKTIM SNKGSALMGIGIATGENRAAEAAKKAISSPLLEAAIDGAQGVLMNITGGTNLSLYEVQ EAADIVASASDQDVNMIFGSVINENLKDEIVVTVIATGFIEQEKDVTKPQRPSLNQSI KTHNQSVPKREPKREEPQQQNTVSRHTSQPADDTLDIPTFLRNRNKRG*" /label="ftsZ CDS" gene 1510160..1511308 /gene="ftsZ" /locus_tag="BSU_15290" /old_locus_tag="BSU15290" /label="ftsZ gene" downshifts 1511282 /Source="Nicolas_upshifts" /id="D864" /incds=0 /nref=226 /ntot=389 /MaxReadThrough="2.85051" /MaxDrop="7.70428" /score="34.7919519" /energy="-13.7" /TU="U1267,U1271" /idTUdmin="U1269" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" S_feature 1511507..1511610 /Source="Nicolas_S_feature" /locus_tag="new_1599179_1599282" /HighExp="T5.0H, BC, T4.0H, T3.30H, T3.0H, S2, BT, M9-stat, T2.30H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.953" /TUlongSig="SigA, SigWXY, SigA, Sig-" /TUlongPSig="0.989, 1, 1, 0.436" /label="S561" upshifts 1511507 /Source="Nicolas_upshifts" /id="U1273" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.453546453546454" /psig="0.953046953046953" /xcortree=486 /SigmaFactorBS="tttttatcattttcatatatatggaaattgaatgacatgaaa cgacaatatctgtaattcagATTGTCTACAGTTAATATACagcgatgttctgacaaac c" /listShort="S561, bpr" /GFF_Attribute="listLong" /label="upshifts" misc_feature 1511509..1511528 /Source="Nicolas_upshift_promotors" /id="U1273" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.453546453546454" /psig="0.953046953046953" /xcortree=486 /SigmaFactorBS="tttttatcattttcatatatatggaaattgaatgacatgaaa cgacaatatctgtaattcagATTGTCTACAGTTAATATACagcgatgttctgacaaac c" /listShort="S561, bpr" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 1511611..1515912 /gene="bpr" /locus_tag="BSU_15300" /old_locus_tag="BSU15300" /EC_number="3.4.21.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1368833, 1938892, 2106512, 2108961, 15205417, 15375126, 18194340, 18414485, 26497454" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1368833, 1938892, 2106512, 2108961, 15205417, 15375126, 18194340, 18414485, 26497454; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bacillopeptidase F" /protein_id="NP_389413.1" /db_xref="EnsemblGenomes-Gn:BSU15300" /db_xref="EnsemblGenomes-Tr:CAB13403" /db_xref="GOA:P16397" /db_xref="InterPro:IPR000209" /db_xref="InterPro:IPR008757" /db_xref="InterPro:IPR008969" /db_xref="InterPro:IPR008979" /db_xref="InterPro:IPR010259" /db_xref="InterPro:IPR012103" /db_xref="InterPro:IPR013320" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR015500" /db_xref="InterPro:IPR022398" /db_xref="InterPro:IPR023828" /db_xref="InterPro:IPR033857" /db_xref="InterPro:IPR036852" /db_xref="InterPro:IPR037045" /db_xref="SubtiList:BG10233" /db_xref="UniProtKB/Swiss-Prot:P16397" /translation="MRKKTKNRLISSVLSTVVISSLLFPGAAGASSKVTSPSVKKELQ SAESIQNKISSSLKKSFKKKEKTTFLIKFKDLANPEKAAKAAVKKAKSKKLSAAKTEY QKRSAVVSSLKVTADESQQDVLKYLNTQKDKGNADQIHSYYVVNGIAVHASKEVMEKV VQFPEVEKVLPNEKRQLFKSSSPFNMKKAQKAIKATDGVEWNVDQIDAPKAWALGYDG TGTVVASIDTGVEWNHPALKEKYRGYNPENPNEPENEMNWYDAVAGEASPYDDLAHGT HVTGTMVGSEPDGTNQIGVAPGAKWIAVKAFSEDGGTDADILEAGEWVLAPKDAEGNP HPEMAPDVVNNSWGGGSGLDEWYRDMVNAWRAADIFPEFSAGNTDLFIPGGPGSIANP ANYPESFATGATDINKKLADFSLQGPSPYDEIKPEISAPGVNIRSSVPGQTYEDGWDG TSMAGPHVSAVAALLKQANASLSVDEMEDILTSTAEPLTDSTFPDSPNNGYGHGLVNA FDAVSAVTDGLGKAEGQVSVEGDDQEPPVYQHEKVTEAYEGGSLPLTLTAEDNVSVTS VKLSYKLDQGEWTEITAKRISGDHLKGTYQAEIPDIKGTKLSYKWMIHDFGGHVVSSD VYDVTVKPSITAGYKQDFETAPGGWVASGTNNNWEWGVPSTGPNTAASGEKVYGTNLT GNYANSANMNLVMPPIKAPDSGSLFLQFKSWHNLEDDFDYGYVFVLPEGEKNWEQAGV YNGKTSSWTDEEIDLSAYKGQNIQVMFNLQSDESIAKEGWYIDDVVLSDKSAGKTVKK NKLGVEKPSGKQKKKPVNPKKAKPSANTAVKHQNKAIQPQVLPLKAQVSVVETGKSTY SDQSTGQYTLKHKAGDYTLMAEAYGYQSKTQKVSLKTDQTTQANFTLEEMKKGTLKGT VINKTTGEPVTGASVYVVEDAAVEPAMTNDKGEYMLEAYEGAYTIKVAAPGYYSDEFS VELKGDVTKETALKPFVGYPGEIAYDDGTAENANSYFAAGNGWAVKMTLADGKDKGML TGGLFRFWDTEFPDPGGTEFKVEVYDATGKDGAPGKKIAGPFNAEALRNGEWTKVDLS SKGIMVDKDFYLVYIQSKPDPYSPGLAMDETGQNSGRNWQYIDGKWQPGDKADGNYMI RALVDYEAAVPEITSPTDKSYTNKDSVTVKGNASPGTTVHIYNGEKEAGETKAAADGT FHAGIILNKGENELTATASTDNGTTDASSPITVTLDQEKPELTLDNPKDGGKTNKETL TVKGAVSDDNLKDVKVNGKKATVADGSYSARILLENGRNEIKVIATDLAGNKTTKKTV IDVNFDKPVISGLIPGEDKNLKAGESVKIAFSSAEDLDATFTIRMPLTNARASVQNAT ELPLREISPGRYEGYWTATSSIKAKGAKVEVIVRDDYGNETRKTANGKLNMNTEN*" /label="bpr CDS" gene 1511611..1515912 /gene="bpr" /locus_tag="BSU_15300" /old_locus_tag="BSU15300" /label="bpr gene" downshifts 1515909 /Source="Nicolas_upshifts" /id="D865" /incds=0 /nref=73 /ntot=169 /MaxReadThrough="0.90839" /MaxDrop="8.78054" /score="38.0577497" /energy="-11.4" /TU="NA" /idTUdmin="U1273" /TUdmin=1 /isTUend="TRUE" /label="downshifts" S_feature complement(1515920..1517062) /Source="Nicolas_S_feature" /locus_tag="new_1603592_1604734_c" /HighExp="S8, S6, S7, S5, LoTm, S4, B36, T5.0H, BT, B60" /AntisenseName="spoIIGA" /AntisenseCor="0.71080549463714104" /AntisenseRegPval="-42" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.579" /TUlongSig="NA" /TUlongPSig="NA" /label="S562" downshifts complement(1515962) /Source="Nicolas_upshifts" /id="D866" /incds=0 /nref=5 /ntot=22 /MaxReadThrough="2.36451" /MaxDrop="3.61596" /score="22.1321546" /energy="-9.6" /TU="NA" /idTUdmin="U1275" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1516040..1516106 /Source="Nicolas_S_feature" /locus_tag="new_1603712_1603778" /HighExp="M9-stat, T5.0H, S4, LoTm, T3.30H, T3.0H, B60, S3, S5, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.534" /TUlongSig="NA" /TUlongPSig="NA" /label="S563" upshifts 1516042 /Source="Nicolas_upshifts" /id="U1274" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.282717282717283" /psig="0.534465534465534" /xcortree=966 /SigmaFactorBS="gcagatttccctgaaaaattgtattttcctctcaacattaat tgacagactttcccacagaGCTTGCTTTATACTTATGAAgcaagaaggggaacagcgt g" /listShort="S563, spoIIGA, sigE, S564, sigG, S565" /listLong="ylmA, NA, thiQ" /label="upshifts" misc_feature 1516043..1516062 /Source="Nicolas_upshift_promotors" /id="U1274" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.282717282717283" /psig="0.534465534465534" /xcortree=966 /SigmaFactorBS="gcagatttccctgaaaaattgtattttcctctcaacattaat tgacagactttcccacagaGCTTGCTTTATACTTATGAAgcaagaaggggaacagcgt g" /listShort="S563, spoIIGA, sigE, S564, sigG, S565" /listLong="ylmA, NA, thiQ" /label="promotor_single_box" /note="Geneious type: promotor_single_box" misc_feature complement(1516060..1516072) /Source="Nicolas_upshift_promotors" /id="U1275" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.430569430569431" /psig="0.185814185814186" /xcortree=1053 /SigmaFactorBS="caaatgacatctaaatagattttcacatctgactcctttctt tcttgcctcacgctgttcCCCTTCTTGCTTCataagtataaagcaagctctgtgggaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1516072) /Source="Nicolas_upshifts" /id="U1275" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.430569430569431" /psig="0.185814185814186" /xcortree=1053 /SigmaFactorBS="caaatgacatctaaatagattttcacatctgactcctttctt tcttgcctcacgctgttcCCCTTCTTGCTTCataagtataaagcaagctctgtgggaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1516107..1517036 /gene="spoIIGA" /locus_tag="BSU_15310" /old_locus_tag="BSU15310" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:7585939, 7729420, 9573195, 9663680, 10498732, 15849754, 16850406, 18378688, 21362630, 22111992" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7585939, 7729420, 9573195, 9663680, 10498732, 15849754, 16850406, 18378688, 21362630, 22111992; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protease processing pro-sigma-E" /protein_id="NP_389414.1" /db_xref="EnsemblGenomes-Gn:BSU15310" /db_xref="EnsemblGenomes-Tr:CAB13405" /db_xref="GOA:P13801" /db_xref="InterPro:IPR005081" /db_xref="SubtiList:BG10234" /db_xref="UniProtKB/Swiss-Prot:P13801" /translation="MKIYLDVIWLLNFCFDALLLLLTAFILKRHVKKRRLVGGAFIGS SIVLLMFTPFSPIVEHPAGKLAFSVVIVVVTFGFKRFRFFFQNLFSFYFATFLMGGGI IGAHSLLQSNSIVQNGVMITNQTGFGDPISWLFIVGGFPALWFFSKRRIEDIETKNIQ YEERVSVQADLGSQTLHVRGLIDSGNQLYDPLTKTPVMIIYIDKLEPIFGTAETMIIR NTDPLEAIEQLDDSFRFLDKMRLIPYRGVGQQNQFLLCVKPDHVTIMTKEEMISADKC LIGISTTKLSADGEFDAIIHPKMLSGKAVKHVS*" /label="spoIIGA CDS" gene 1516107..1517036 /gene="spoIIGA" /locus_tag="BSU_15310" /old_locus_tag="BSU15310" /label="spoIIGA gene" promotor_-10 complement(1517051..1517070) /Source="Nicolas_upshift_promotors" /id="U1276" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.494505494505495" /psig="0.57942057942058" /xcortree=1054 /SigmaFactorBS="gtcaaccgtaatttcagttttttcatcttcctctccCTTCta aatgtcacgccgTTTGAGTATGATAAGTAACGgacatttgcgaacattatgaaacgtg t" /listShort="S562" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1517064) /Source="Nicolas_upshifts" /id="U1276" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.494505494505495" /psig="0.57942057942058" /xcortree=1054 /SigmaFactorBS="gtcaaccgtaatttcagttttttcatcttcctctccCTTCta aatgtcacgccgTTTGAGTATGATAAGTAACGgacatttgcgaacattatgaaacgtg t" /listShort="S562" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1517085..1517088) /Source="Nicolas_upshift_promotors" /id="U1276" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.494505494505495" /psig="0.57942057942058" /xcortree=1054 /SigmaFactorBS="gtcaaccgtaatttcagttttttcatcttcctctccCTTCta aatgtcacgccgTTTGAGTATGATAAGTAACGgacatttgcgaacattatgaaacgtg t" /listShort="S562" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1517099..1517818 /gene="sigE" /locus_tag="BSU_15320" /old_locus_tag="BSU15320" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1581961, 7708009, 8464402, 15187183, 20802044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1581961, 7708009, 8464402, 15187183, 20802044; Product type f: factor" /codon_start=1 /transl_table=11 /product="RNA polymerase sporulation-specific sigma-29 factor (sigma-E)" /protein_id="NP_389415.2" /db_xref="EnsemblGenomes-Gn:BSU15320" /db_xref="EnsemblGenomes-Tr:CAB13406" /db_xref="GOA:P06222" /db_xref="InterPro:IPR000943" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR007630" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014200" /db_xref="InterPro:IPR014284" /db_xref="SubtiList:BG10235" /db_xref="UniProtKB/Swiss-Prot:P06222" /translation="MKKLKLRLTHLWYKLLMKLGLKSDEVYYIGGSEALPPPLSKDEE QVLLMKLPNGDQAARAILIERNLRLVVYIARKFENTGINIEDLISIGTIGLIKAVNTF NPEKKIKLATYASRCIENEILMYLRRNNKIRSEVSFDEPLNIDWDGNELLLSDVLGTD DDIITKDIEANVDKKLLKKALEQLNEREKQIMELRFGLVGEEEKTQKDVADMMGISQS YISRLEKRIIKRLRKEFNKMV*" /label="sigE CDS" gene 1517099..1517818 /gene="sigE" /locus_tag="BSU_15320" /old_locus_tag="BSU15320" /label="sigE gene" S_feature 1517819..1517908 /Source="Nicolas_S_feature" /locus_tag="new_1605491_1605580" /HighExp="T5.0H, S3, M9-stat, T4.0H, S4, LoTm, S2, B60, B36, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.534" /TUlongSig="NA" /TUlongPSig="NA" /label="S564" promotor_-35 1517892..1517898 /Source="Nicolas_upshift_promotors" /id="U1277" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.923076923076923" /psig="0.923076923076923" /xcortree=1135 /SigmaFactorBS="cagggatttcctgatttcgacagtttttcggtctgagtgcag TGCATATttttcccacccaaGGAGATACTTAAcgttgtacagcagctcctgtagggag g" /listShort="sigG" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1517910 /Source="Nicolas_upshifts" /id="U1277" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.923076923076923" /psig="0.923076923076923" /xcortree=1135 /SigmaFactorBS="cagggatttcctgatttcgacagtttttcggtctgagtgcag TGCATATttttcccacccaaGGAGATACTTAAcgttgtacagcagctcctgtagggag g" /listShort="sigG" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1517912..1517923 /Source="Nicolas_upshift_promotors" /id="U1277" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.923076923076923" /psig="0.923076923076923" /xcortree=1135 /SigmaFactorBS="cagggatttcctgatttcgacagtttttcggtctgagtgcag TGCATATttttcccacccaaGGAGATACTTAAcgttgtacagcagctcctgtagggag g" /listShort="sigG" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1517958..1518740 /gene="sigG" /locus_tag="BSU_15330" /old_locus_tag="BSU15330" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15187183, 15256570, 16166546, 16497325, 17015665, 21935351" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15187183, 15256570, 16166546, 16497325, 17015665, 21935351; Product type f : factor" /codon_start=1 /transl_table=11 /product="RNA polymerase sporulation-specific sigma factor(sigma-G)" /protein_id="NP_389416.1" /db_xref="EnsemblGenomes-Gn:BSU15330" /db_xref="EnsemblGenomes-Tr:CAB13407" /db_xref="GOA:P19940" /db_xref="InterPro:IPR000943" /db_xref="InterPro:IPR007624" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR007630" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014212" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR014322" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10236" /db_xref="UniProtKB/Swiss-Prot:P19940" /translation="MSRNKVEICGVDTSKLPVLKNEEMRKLFRQLQDEGDDSAREKLV NGNLRLVLSVIQRFNNRGEYVDDLFQVGCIGLMKSIDNFDLSHNVKFSTYAVPMIIGE IRRYLRDNNPIRVSRSLRDIAYKALQVRERLISETSKEPTAEDIAKVLEVPHEEIVFA LDAIQDPVSLFEPIYNDGGDPIYVMDQISDERNTDSQWIEELALKEGMRRLNDREKMI LRKRFFQGKTQMEVAEEIGISQAQVSRLEKAAIKQMNKNIHQ*" /label="sigG CDS" gene 1517958..1518740 /gene="sigG" /locus_tag="BSU_15330" /old_locus_tag="BSU15330" /label="sigG gene" S_feature 1518741..1518829 /Source="Nicolas_S_feature" /locus_tag="new_1606413_1606501" /HighExp="LoTm, S7, S8, BT, S6, S4, G/S, S3, S2, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.534" /TUlongSig="NA" /TUlongPSig="NA" /label="S565" promotor_-35 1518794..1518801 /Source="Nicolas_upshift_promotors" /id="U1278" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.323676323676324" /psig="0.98901098901099" /xcortree=2908 /SigmaFactorBS="aggcttttctattgattatggatGGTTTACGttttggaaaaa gTAAGGTATCCTAGTTCGTACaaagttttatgaaaattaaaacaattataaaaggcaa t" /listShort="ylmA, NA, thiQ, ylmC, S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1518814..1518833 /Source="Nicolas_upshift_promotors" /id="U1278" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.323676323676324" /psig="0.98901098901099" /xcortree=2908 /SigmaFactorBS="aggcttttctattgattatggatGGTTTACGttttggaaaaa gTAAGGTATCCTAGTTCGTACaaagttttatgaaaattaaaacaattataaaaggcaa t" /listShort="ylmA, NA, thiQ, ylmC, S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1518831 /Source="Nicolas_upshifts" /id="U1278" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.323676323676324" /psig="0.98901098901099" /xcortree=2908 /SigmaFactorBS="aggcttttctattgattatggatGGTTTACGttttggaaaaa gTAAGGTATCCTAGTTCGTACaaagttttatgaaaattaaaacaattataaaaggcaa t" /listShort="ylmA, NA, thiQ, ylmC, S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="upshifts" CDS 1518888..1519682 /gene="ylmA" /locus_tag="BSU_15340" /old_locus_tag="BSU15340" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16707683, 18083814; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_389417.2" /db_xref="EnsemblGenomes-Gn:BSU15340" /db_xref="EnsemblGenomes-Tr:CAB13408" /db_xref="GOA:O31723" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13370" /db_xref="UniProtKB/Swiss-Prot:O31723" /translation="MILQLDNVSLKRNGKWILKDIHWKVEEKENWVLYGLNGAGKTAL LNMLCSYYFPTSGEMQVLGHEFGKTELGEKLRRKIGLVSAALQQKLYPADSAFEIALS GAYASIGLYETPSKETREKAIGLLEDLGAIEYADRRYETLSQGEKQRALIARALMADP ELLILDEPVTGLDFIAREKLLDTITYIANKENAPSILYVTHHAEEILPVFDKALLLKQ GEVFGSGEIKEMLTDQILSAFFDTPIHVLWNQDRPFLTRAEPITNA*" /label="ylmA CDS" gene 1518888..1519682 /gene="ylmA" /locus_tag="BSU_15340" /old_locus_tag="BSU15340" /label="ylmA gene" promotor_-35 1519600..1519603 /Source="Nicolas_upshift_promotors" /id="U1279" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.9000999000999" /psig="0.976023976023976" /xcortree=567 /SigmaFactorBS="ataaaggaaatgcttactgatcaaatactttccgCTTTtttt gatacgccaaTCCATGTATTATGGAATCAGgatcggccgtttttaacaagagctgagc c" /listShort="NA, thiQ, ylmC, S566" /listLong="ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /label="promotor_-35" promotor_-10 1519618..1519637 /Source="Nicolas_upshift_promotors" /id="U1279" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.9000999000999" /psig="0.976023976023976" /xcortree=567 /SigmaFactorBS="ataaaggaaatgcttactgatcaaatactttccgCTTTtttt gatacgccaaTCCATGTATTATGGAATCAGgatcggccgtttttaacaagagctgagc c" /listShort="NA, thiQ, ylmC, S566" /listLong="ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /label="promotor_-10" upshifts 1519626 /Source="Nicolas_upshifts" /id="U1279" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.9000999000999" /psig="0.976023976023976" /xcortree=567 /SigmaFactorBS="ataaaggaaatgcttactgatcaaatactttccgCTTTtttt gatacgccaaTCCATGTATTATGGAATCAGgatcggccgtttttaacaagagctgagc c" /listShort="NA, thiQ, ylmC, S566" /listLong="ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /label="upshifts" misc_RNA 1519695..1519796 /gene="tswE" /locus_tag="BSU_misc_RNA_24" /product="thiamine pyrophosphate riboswitch" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11470904, 12410317, 15862294, 16728979, 16962976, 17307816, 18179415, 18776013; Product type n: RNA" /function="16.3: Control" /label="tswE RNA" gene 1519695..1519796 /gene="tswE" /locus_tag="BSU_misc_RNA_24" /label="tswE gene" downshifts 1519783 /Source="Nicolas_upshifts" /id="D867" /incds=0 /nref=7 /ntot=53 /MaxReadThrough="5.58534" /MaxDrop="4.3688" /score="-2.39598083" /energy="-7.1" /TU="U1278,U1279" /idTUdmin="U1274" /TUdmin=971 /isTUend="FALSE" /label="downshifts" CDS 1519884..1521164 /gene="thiQ" /locus_tag="BSU_15350" /old_locus_tag="BSU15350" /EC_number="3.5.1.-" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17618314" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17618314; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-formyl-4-amino-5-aminomethyl-2- methylpyrimidinedeformylase" /protein_id="NP_389418.2" /db_xref="EnsemblGenomes-Gn:BSU15350" /db_xref="EnsemblGenomes-Tr:CAB13409" /db_xref="GOA:O31724" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR010182" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG13371" /db_xref="UniProtKB/Swiss-Prot:O31724" /translation="MDQQIYSLQKKVEEHKEELIQLAKTLISYQTPAPPARNTEGIQS WIAGYLNELGFSIDKWDVYPGDPNVVGKLKGTDSADYYSLIINGHVDVAEVKEDEEWK HDPFHPIEKNGLLIGRGASDMKGGMACVLFAVKLIREASIELPGDLILQSVIGEEVGE AGTLECCKRGYHADFAIVADTSDMHIQGQGGVITGWIEIKSSQTFHDGTRRNMIHAGG GTFGASAIEKMAKIIAGLGELERHWSIMKSYPGFKPGTNTINPAVIEGGRHAAFIADE CRLWITVHFYPNETHDQVAAEIEDYVNRLSDSDIWLRENRPVFKWGGSSMIEDRGEIF PALEVDPGHPGVLALTASHQKVKRECPIIDVSQSVTDGGWLYDAGIPCVIYGPGDLHN AHSVNEKVSIEQLVEYTKIILDFIISWCSRKKEQ*" /label="thiQ CDS" gene 1519884..1521164 /gene="thiQ" /locus_tag="BSU_15350" /old_locus_tag="BSU15350" /label="thiQ gene" misc_feature complement(1521105..1521121) /Source="Nicolas_upshift_promotors" /id="U1280" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.407592407592408" /psig="0.715284715284715" /xcortree=1716 /SigmaFactorBS="ttcatgtcattgttcttttttccggctgcaccagctgatgat aaaatcgAGTATAATTTTTGTATActctactagctgctcaatcgataccttctcgttc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1521110) /Source="Nicolas_upshifts" /id="U1280" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.407592407592408" /psig="0.715284715284715" /xcortree=1716 /SigmaFactorBS="ttcatgtcattgttcttttttccggctgcaccagctgatgat aaaatcgAGTATAATTTTTGTATActctactagctgctcaatcgataccttctcgttc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1521185..1521190 /Source="Nicolas_upshift_promotors" /id="U1281" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1082 /SigmaFactorBS="aaaaaagaacaatgacatgaaaatttcttcttgctGACAAGg ttcagcctgcccgtTCATATACTTGAACAAAAGgacggaaaaaggacgtgatggaatg a" /listShort="ylmC, S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA" /listLong="NA, ileS" /label="promotor_-35" promotor_-10 1521206..1521224 /Source="Nicolas_upshift_promotors" /id="U1281" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1082 /SigmaFactorBS="aaaaaagaacaatgacatgaaaatttcttcttgctGACAAGg ttcagcctgcccgtTCATATACTTGAACAAAAGgacggaaaaaggacgtgatggaatg a" /listShort="ylmC, S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA" /listLong="NA, ileS" /label="promotor_-10" upshifts 1521210 /Source="Nicolas_upshifts" /id="U1281" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1082 /SigmaFactorBS="aaaaaagaacaatgacatgaaaatttcttcttgctGACAAGg ttcagcctgcccgtTCATATACTTGAACAAAAGgacggaaaaaggacgtgatggaatg a" /listShort="ylmC, S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA" /listLong="NA, ileS" /label="upshifts" CDS 1521247..1521492 /gene="ylmC" /locus_tag="BSU_15360" /old_locus_tag="BSU15360" /experiment="publication(s) with functional evidences, PMID:12429060, 23396918" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12429060, 23396918; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="essential sporulation protein" /protein_id="NP_389419.1" /db_xref="EnsemblGenomes-Gn:BSU15360" /db_xref="EnsemblGenomes-Tr:CAB13410" /db_xref="InterPro:IPR011033" /db_xref="InterPro:IPR014238" /db_xref="InterPro:IPR027275" /db_xref="SubtiList:BG13372" /db_xref="UniProtKB/Swiss-Prot:O31725" /translation="MISISEFQVKDVVNVSNGKKLGSIGDIDINVTTGKIQAIILGGN GKVLGFFGKEEELVIPWRNIVKIGEDVILVRLSEPHA*" /label="ylmC CDS" gene 1521247..1521492 /gene="ylmC" /locus_tag="BSU_15360" /old_locus_tag="BSU15360" /label="ylmC gene" promotor_-35 1521408..1521416 /Source="Nicolas_upshift_promotors" /id="U1282" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=534 /SigmaFactorBS="aaatgggaaagttctcggattttttggaaaagaAGAGGAATT ggtcattccaTGGCGAAATATAGTAAAAAtcggggaagatgtaatcttagtccgatta a" /listShort="S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1521427..1521445 /Source="Nicolas_upshift_promotors" /id="U1282" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=534 /SigmaFactorBS="aaatgggaaagttctcggattttttggaaaagaAGAGGAATT ggtcattccaTGGCGAAATATAGTAAAAAtcggggaagatgtaatcttagtccgatta a" /listShort="S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1521435 /Source="Nicolas_upshifts" /id="U1282" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=534 /SigmaFactorBS="aaatgggaaagttctcggattttttggaaaagaAGAGGAATT ggtcattccaTGGCGAAATATAGTAAAAAtcggggaagatgtaatcttagtccgatta a" /listShort="S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="upshifts" S_feature 1521493..1521603 /Source="Nicolas_S_feature" /locus_tag="new_1609165_1609275" /HighExp="T3.0H, S2, S1, T4.0H, T3.30H, T5.0H, T2.0H, BC, Gly, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.34150000000000003" /TUshortSig="SigH, SigEF, SigA, SigA" /TUshortPSig="1, 0.998, 0.976, 0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S566" misc_feature 1521595..1521614 /Source="Nicolas_upshift_promotors" /id="U1283" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.884115884115884" /psig=1 /xcortree=2210 /SigmaFactorBS="cacatttcatttagaaatatgcaaatcggcgctcaacgaatg cagtaagaTGTGGTAAAATAAGTGGGAAattccgcttttttaaatgtttgtcgaaagg t" /listShort="ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1521605 /Source="Nicolas_upshifts" /id="U1283" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.884115884115884" /psig=1 /xcortree=2210 /SigmaFactorBS="cacatttcatttagaaatatgcaaatcggcgctcaacgaatg cagtaagaTGTGGTAAAATAAGTGGGAAattccgcttttttaaatgtttgtcgaaagg t" /listShort="ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="upshifts" CDS 1521655..1522491 /gene="ylmD" /locus_tag="BSU_15370" /old_locus_tag="BSU15370" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16498617, 19737354; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="conserved protein with laccase domain" /protein_id="NP_389420.1" /db_xref="EnsemblGenomes-Gn:BSU15370" /db_xref="EnsemblGenomes-Tr:CAB13411" /db_xref="GOA:O31726" /db_xref="InterPro:IPR003730" /db_xref="InterPro:IPR011324" /db_xref="SubtiList:BG13373" /db_xref="UniProtKB/Swiss-Prot:O31726" /translation="MNTYHPFSLTTPSTLMIQDWAQTNQNNKEVIAGFTTKNGGVSQK PFESLNTGLHVHDKDADVVKNREYIADMFNTDLQSWVFADQTHDNRVQKVTQRDRGKG AREYHTALKATDGIYTNEKNVFLALCFADCVPLFFYDPVKSLVGVAHAGWKGTVKQIG REMVKQWTEKEGSNPSDIYAVIGPSISGACYTVDDRVMDAVRALPVSADLAANQTAKA QYQLDLKELNRLILMDSGLASEQISVSGLCTESEPSLFYSHRRDQGKTGRMMSFIGMK EA*" /label="ylmD CDS" gene 1521655..1522491 /gene="ylmD" /locus_tag="BSU_15370" /old_locus_tag="BSU15370" /label="ylmD gene" CDS 1522498..1523190 /gene="ylmE" /locus_tag="BSU_15380" /old_locus_tag="BSU15380" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14526035, 24097949; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative PLP-containing enzyme" /protein_id="NP_389421.1" /db_xref="EnsemblGenomes-Gn:BSU15380" /db_xref="EnsemblGenomes-Tr:CAB13412" /db_xref="GOA:O31727" /db_xref="InterPro:IPR001608" /db_xref="InterPro:IPR011078" /db_xref="InterPro:IPR029066" /db_xref="SubtiList:BG13374" /db_xref="UniProtKB/Swiss-Prot:O31727" /translation="MRVVDNLRHINERINEACNRSGRSSDEVTVIAVTKYVSPERAQE AVDAGITCLGENRDAELLRKQELMKGNPEWHFIGSLQSRKAKSVVNSVSYIHSLDRLS LAKEIEKRAEGTVRCFVQVNTSLEPSKHGMKKEEVIPFIQELSGFEHILVAGLMTMAP LTDDQDQIRSCFRSLRELRDQVQKLNQPNAPCTELSMGMSNDFEIAIEEGATYIRIGS SLVGNETGGVQQ*" /label="ylmE CDS" gene 1522498..1523190 /gene="ylmE" /locus_tag="BSU_15380" /old_locus_tag="BSU15380" /label="ylmE gene" CDS 1523187..1523642 /gene="sepF" /locus_tag="BSU_15390" /old_locus_tag="BSU15390" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:14526035, 16420366, 16796675, 18782755, 22912848, 24218584" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14526035, 16420366, 16796675, 18782755, 22912848, 24218584; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="cell division machinery factor" /protein_id="NP_389422.3" /db_xref="EnsemblGenomes-Gn:BSU15390" /db_xref="EnsemblGenomes-Tr:CAB13413" /db_xref="GOA:O31728" /db_xref="InterPro:IPR007561" /db_xref="InterPro:IPR023052" /db_xref="PDB:3ZIH" /db_xref="PDB:3ZII" /db_xref="SubtiList:BG13375" /db_xref="UniProtKB/Swiss-Prot:O31728" /translation="MSMKNKLKNFFSMEDEEYEYEYIETERESHEEHEQKEKPAYNGN KPAGKQNVVSLQSVQKSSKVVLSEPRVYAEAQEIADHLKNRRAVVVNLQRIQHDQAKR IVDFLSGTVYAIGGDIQRIGSDIFLCTPDNVDVSGTISELISEDEHQRW*" /label="sepF CDS" gene 1523187..1523642 /gene="sepF" /locus_tag="BSU_15390" /old_locus_tag="BSU15390" /label="sepF gene" CDS 1523649..1523921 /gene="ylmG" /locus_tag="BSU_15400" /old_locus_tag="BSU15400" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14526035, 19966467, 20359373; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor involved in shape determination, distribution of nucleoids and osmotic tolerance" /protein_id="NP_389423.1" /db_xref="EnsemblGenomes-Gn:BSU15400" /db_xref="EnsemblGenomes-Tr:CAB13414" /db_xref="GOA:O31729" /db_xref="InterPro:IPR003425" /db_xref="SubtiList:BG13376" /db_xref="UniProtKB/Swiss-Prot:O31729" /translation="MILYQVFSVLSLLITIYSFALIIYIFMSWVPSTRETAVGRFLAS ICEPYLEPFRKIIPPIAMLDISPIVAILVLRFATTGLWGLYRMIAF*" /label="ylmG CDS" gene 1523649..1523921 /gene="ylmG" /locus_tag="BSU_15400" /old_locus_tag="BSU15400" /label="ylmG gene" downshifts 1523910 /Source="Nicolas_upshifts" /id="D868" /incds=0 /nref=16 /ntot=97 /MaxReadThrough="6.19839" /MaxDrop="4.93537" /score="-6.17078585" /energy="-15.2" /TU="U1278,U1281,U1282,U1283" /idTUdmin="U1281" /TUdmin="-1452" /isTUend="FALSE" /label="downshifts" CDS 1523982..1524755 /gene="ylmH" /locus_tag="BSU_15410" /old_locus_tag="BSU15410" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10093218, 14526035, 21141807; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor involved in shape determination, RNA-binding fold" /protein_id="NP_389424.1" /db_xref="EnsemblGenomes-Gn:BSU15410" /db_xref="EnsemblGenomes-Tr:CAB13415" /db_xref="GOA:P71020" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG11856" /db_xref="UniProtKB/Swiss-Prot:P71020" /translation="MSDIYQHFRKDERAFIDQALEWKRIVQEQYRMKLTDFLDPREQV ILSAVTGQADVGLAFSGGYDRAERKRAILFPEYITPEESDFELQAFNVRYADKFVSVD HRSLLGALMGIGLKRQKFGDIVFSETAVQLIVSADTADFVAAQLTQAGKAAVSLEKID LSDLNIPAVDVEIRDDTVSSLRLDAVCASMSRQSRQKSQTLVKNGLVKVNWKVVEDPS YIVAEGDMLSIRGFGRCSLTKIEGKTKKDKWRVTFERQK*" /label="ylmH CDS" gene 1523982..1524755 /gene="ylmH" /locus_tag="BSU_15410" /old_locus_tag="BSU15410" /label="ylmH gene" promotor_-35 1524471..1524478 /Source="Nicolas_upshift_promotors" /id="U1284" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1638 /SigmaFactorBS="aatcgacttgtcagacCTTAACATtccagcagttgatGTCGA AATAAGAGATGACAcggtttcttctttaaggcttgacgccgtctgcgcctctatgagc a" /listShort="S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1524492..1524510 /Source="Nicolas_upshift_promotors" /id="U1284" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1638 /SigmaFactorBS="aatcgacttgtcagacCTTAACATtccagcagttgatGTCGA AATAAGAGATGACAcggtttcttctttaaggcttgacgccgtctgcgcctctatgagc a" /listShort="S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1524515 /Source="Nicolas_upshifts" /id="U1284" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1638 /SigmaFactorBS="aatcgacttgtcagacCTTAACATtccagcagttgatGTCGA AATAAGAGATGACAcggtttcttctttaaggcttgacgccgtctgcgcctctatgagc a" /listShort="S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="upshifts" S_feature 1524756..1524848 /Source="Nicolas_S_feature" /locus_tag="new_1612428_1612520" /HighExp="C90, M0t90, C30, GM-0.1, Glucon, MG 5, GM 45, GM 5, GM 60, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA, SigH, SigEF, SigA" /TUshortPSig="0.973, 1, 1, 0.998, 0.989" /TUlongSig="SigA" /TUlongPSig="0.976" /label="S567" CDS 1524849..1525343 /gene="divIVA" /locus_tag="BSU_15420" /old_locus_tag="BSU15420" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10724454, 12950914, 14526035, 15165232, 15554965, 16885474, 22108385, 22582279, 23264578, 24129255, 28674273" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10724454, 12950914, 14526035, 15165232, 15554965, 16885474, 22108385, 22582279, 23264578, 24129255, 28674273; Product type f : factor" /codon_start=1 /transl_table=11 /product="cell-division initiation protein" /protein_id="NP_389425.1" /db_xref="EnsemblGenomes-Gn:BSU15420" /db_xref="EnsemblGenomes-Tr:CAB13416" /db_xref="GOA:P71021" /db_xref="InterPro:IPR007793" /db_xref="InterPro:IPR019933" /db_xref="PDB:2WUJ" /db_xref="PDB:2WUK" /db_xref="SubtiList:BG11835" /db_xref="UniProtKB/Swiss-Prot:P71021" /translation="MPLTPNDIHNKTFTKSFRGYDEDEVNEFLAQVRKDYEIVLRKKT ELEAKVNELDERIGHFANIEETLNKSILVAQEAAEDVKRNSQKEAKLIVREAEKNADR IINESLSKSRKIAMEIEELKKQSKVFRTRFQMLIEAQLDLLKNDDWDHLLEYEVDAVF EEKE*" /label="divIVA CDS" gene 1524849..1525343 /gene="divIVA" /locus_tag="BSU_15420" /old_locus_tag="BSU15420" /label="divIVA gene" promotor_-35 1525356..1525363 /Source="Nicolas_upshift_promotors" /id="U1285" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.556443556443556" /psig="0.999000999001" /xcortree=597 /SigmaFactorBS="tatttgaggaaaaggaataaattctctgattaTCTTGACAtt ttcttagcttgTCGAATATAATACGTTCATAaattcagatgaaaaaacggttgaaagg g" /listShort="NA, ileS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1525377..1525396 /Source="Nicolas_upshift_promotors" /id="U1285" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.556443556443556" /psig="0.999000999001" /xcortree=597 /SigmaFactorBS="tatttgaggaaaaggaataaattctctgattaTCTTGACAtt ttcttagcttgTCGAATATAATACGTTCATAaattcagatgaaaaaacggttgaaagg g" /listShort="NA, ileS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1525384 /Source="Nicolas_upshifts" /id="U1285" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.556443556443556" /psig="0.999000999001" /xcortree=597 /SigmaFactorBS="tatttgaggaaaaggaataaattctctgattaTCTTGACAtt ttcttagcttgTCGAATATAATACGTTCATAaattcagatgaaaaaacggttgaaagg g" /listShort="NA, ileS" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 1525406..1525632 /gene="iswA" /locus_tag="BSU_misc_RNA_25" /product="T-box riboswitch specific of isoleucine tRNA" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 1317842, 9098041, 12165569, 12547201; Product type n: RNA" /label="iswA RNA" gene 1525406..1525632 /gene="iswA" /locus_tag="BSU_misc_RNA_25" /label="iswA gene" downshifts 1525599 /Source="Nicolas_upshifts" /id="D869" /incds=0 /nref=43 /ntot=100 /MaxReadThrough="7.76706" /MaxDrop="5.97038" /score="48.8352635" /energy="-19.4" /TU="U1278,U1282,U1283,U1284,U1285" /idTUdmin="U1281" /TUdmin=237 /isTUend="FALSE" /label="downshifts" CDS 1525685..1528450 /gene="ileS" /locus_tag="BSU_15430" /old_locus_tag="BSU15430" /EC_number="6.1.1.5" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 16697013, 17043414, 17095543, 28139725; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isoleucyl-tRNA synthetase" /protein_id="NP_389426.2" /db_xref="EnsemblGenomes-Gn:BSU15430" /db_xref="EnsemblGenomes-Tr:CAB13417" /db_xref="GOA:Q45477" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR002300" /db_xref="InterPro:IPR002301" /db_xref="InterPro:IPR009008" /db_xref="InterPro:IPR009080" /db_xref="InterPro:IPR013155" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR023585" /db_xref="InterPro:IPR033708" /db_xref="SubtiList:BG11792" /db_xref="UniProtKB/Swiss-Prot:Q45477" /translation="MDFKDTLLMPKTDFPMRGNLPNREPDIQKKWEEEDIYRLVQERT KDRPKFVLHDGPPYANGDIHMGHALNKILKDFIVRYKSMSGYNAPYVPGWDTHGLPIE TALTKNKKVNRKEMSVAEFRKLCEEYAWKQIEGQREQFKRLGVRGDWENPYVTLKPEY EAQQIRVFGEMAKRGYIYKGLKPVNWSPSSESALAEAEIEYQDKRSASIYVAFGVKDG KGVLENGERIIIWTTTPWTIPANLGISVHPDLEYSVIAVGEDRFVVASALVENVASAC GFDQYEVTRTVKGKDLENIIAEHPLYGRDSLVMLGEHVTTDAGTGCVHTAPGHGEDDF IIGQKYGLDVLCPVDEKGVMTSEAPGFEGMFYDDANKAITQQLDEKGALVKLEFITHS YPHDWRTKKPTIFRATAQWFASIKDFRSDLLDAIKETKWVPEWGEQRLHNMVRDRGDW CISRQRAWGVPIPVFYAENGEPVITDETIEHVSELFRQHGSNIWFEKEAKDLLPEGFT HPGSPNGTFTKEQDIMDVWFDSGSSHQAVLEERDDLVRPADLYLEGSDQYRGWFNSSL STAVAVTGKAPYKGVLSHGFALDGEGRKMSKSIGNVVVPAKVMKQLGADILRLWVSSV DYQADVRVSDAILKQVAEVYRKIRNTFRFLHGNLFDFDPKTNAVAVEDLREVDQYMLI KLNKLIDKVKKAYDEYEFAVVYHSIHNFCTIELSSFYLDFAKDIVYIEHADHPDRRSM QTVFYETLLALVKLSAPILPHTADELWSHLTFVEEQSVQLTDMPETITVPNSEATEEK FDRFMALRDDVLKALETARNEKIIGKSLEANLKLYPNKENKELLASIKENLSQLFIVS ELTISEENEAPNDAQSFATGKIAVEKAEGEMCERSRVISKDVGANPKYPTLSLRNAEI VEKYYQK*" /label="ileS CDS" gene 1525685..1528450 /gene="ileS" /locus_tag="BSU_15430" /old_locus_tag="BSU15430" /label="ileS gene" downshifts 1528441 /Source="Nicolas_upshifts" /id="D870" /incds=0 /nref=233 /ntot=261 /MaxReadThrough="2.6695" /MaxDrop="6.91924" /score="40.2175565" /energy="-13.9" /TU="NA" /idTUdmin="U1278" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" downshifts complement(1528496) /Source="Nicolas_upshifts" /id="D871" /incds=0 /nref=6 /ntot=17 /MaxReadThrough="1.29709" /MaxDrop="3.66645" /score="13.8608728" /energy="-15.6" /TU="NA" /idTUdmin="U1275" /TUdmin="-12534" /isTUend="FALSE" /label="downshifts" promotor_-35 1528531..1528537 /Source="Nicolas_upshift_promotors" /id="U1286" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=855 /SigmaFactorBS="aagagtgacatcctttagaacgaaaggaaaaatcttatgGGC TTTAgatcatcattcacaGGCAACAATAAAgatactacgttaagagcaggagttgtga a" /listShort="ylyA, lspA, rluD" /listLong="NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE" /label="promotor_-35" promotor_-10 1528552..1528563 /Source="Nicolas_upshift_promotors" /id="U1286" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=855 /SigmaFactorBS="aagagtgacatcctttagaacgaaaggaaaaatcttatgGGC TTTAgatcatcattcacaGGCAACAATAAAgatactacgttaagagcaggagttgtga a" /listShort="ylyA, lspA, rluD" /listLong="NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE" /label="promotor_-10" upshifts 1528552 /Source="Nicolas_upshifts" /id="U1286" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=855 /SigmaFactorBS="aagagtgacatcctttagaacgaaaggaaaaatcttatgGGC TTTAgatcatcattcacaGGCAACAATAAAgatactacgttaagagcaggagttgtga a" /listShort="ylyA, lspA, rluD" /listLong="NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE" /label="upshifts" CDS 1528595..1528969 /gene="ylyA" /locus_tag="BSU_15440" /old_locus_tag="BSU15440" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15496987, 23123912, 23678950" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15496987, 23123912, 23678950; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sporulation-related RNA polymerase-binding factor" /protein_id="NP_389427.2" /db_xref="EnsemblGenomes-Gn:BSU15440" /db_xref="EnsemblGenomes-Tr:CAB13418" /db_xref="GOA:Q45478" /db_xref="InterPro:IPR000962" /db_xref="InterPro:IPR016841" /db_xref="InterPro:IPR020458" /db_xref="SubtiList:BG11795" /db_xref="UniProtKB/Swiss-Prot:Q45478" /translation="MNDQLTAIYTELLLMKEELQSRLFEYSCFQVSTSPQAAINQKQK ATLIYHIKEELQDVLLALSKIENGTFGYCEETGAPIPLAKLAVLPTARTANDFLYSVQ FEKKTLPIWKSTDIEYGQALYE*" /label="ylyA CDS" gene 1528595..1528969 /gene="ylyA" /locus_tag="BSU_15440" /old_locus_tag="BSU15440" /label="ylyA gene" promotor_-35 1529001..1529005 /Source="Nicolas_upshift_promotors" /id="U1287" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.953046953046953" /psig=1 /xcortree=2549 /SigmaFactorBS="gtatgaataacagtgtctgtccggttaatatgcctgatattT CTTTactccagtgctttttATTGATAAAATGCATAATGGattaaagtaaccgtaaact g" /listShort="lspA, rluD, NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE, S568" /listLong="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /label="promotor_-35" upshifts 1529020 /Source="Nicolas_upshifts" /id="U1287" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.953046953046953" /psig=1 /xcortree=2549 /SigmaFactorBS="gtatgaataacagtgtctgtccggttaatatgcctgatattT CTTTactccagtgctttttATTGATAAAATGCATAATGGattaaagtaaccgtaaact g" /listShort="lspA, rluD, NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE, S568" /listLong="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /label="upshifts" promotor_-10 1529021..1529040 /Source="Nicolas_upshift_promotors" /id="U1287" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.953046953046953" /psig=1 /xcortree=2549 /SigmaFactorBS="gtatgaataacagtgtctgtccggttaatatgcctgatattT CTTTactccagtgctttttATTGATAAAATGCATAATGGattaaagtaaccgtaaact g" /listShort="lspA, rluD, NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE, S568" /listLong="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /label="promotor_-10" CDS 1529072..1529536 /gene="lspA" /locus_tag="BSU_15450" /old_locus_tag="BSU15450" /EC_number="3.4.23.36" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9880550, 9882689, 10497172, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9880550, 9882689, 10497172, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="signal peptidase II" /protein_id="NP_389428.1" /db_xref="EnsemblGenomes-Gn:BSU15450" /db_xref="EnsemblGenomes-Tr:CAB13419" /db_xref="GOA:Q45479" /db_xref="InterPro:IPR001872" /db_xref="SubtiList:BG11793" /db_xref="UniProtKB/Swiss-Prot:Q45479" /translation="MLYYMIALLIIAADQLTKWLVVKNMELGQSIPIIDQVFYITSHR NTGAAWGILAGQMWFFYLITTAVIIGIVYYIQRYTKGQRLLGVALGLMLGGAIGNFID RAVRQEVVDFIHVIIVNYNYPIFNIADSSLCVGVMLLFIQMLLDSGKKKKEQ*" /label="lspA CDS" gene 1529072..1529536 /gene="lspA" /locus_tag="BSU_15450" /old_locus_tag="BSU15450" /label="lspA gene" CDS 1529538..1530449 /gene="rluD" /locus_tag="BSU_15460" /old_locus_tag="BSU15460" /EC_number="4.2.1.-" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15078091, 15928344, 17188032, 17937767, 18032607, 20817755; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="pseudouridylate synthase" /protein_id="NP_389429.3" /db_xref="EnsemblGenomes-Gn:BSU15460" /db_xref="EnsemblGenomes-Tr:CAB13420" /db_xref="GOA:Q45480" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR006145" /db_xref="InterPro:IPR006224" /db_xref="InterPro:IPR006225" /db_xref="InterPro:IPR020103" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG11796" /db_xref="UniProtKB/Swiss-Prot:Q45480" /translation="MNQIDITASEEQKSERIDKFLASTENDWSRTQVQQWVKDGQVVV NGSAVKANYKIQPGDQVTVTVPEPEALDVLAEPMDLDIYYEDQDVLVVNKPRGMVVHP APGHLTGTLVNGLMAHCTDLSGINGVMRPGIVHRIDKDTSGLLMVAKNDMAHESLVNQ LVNKTVTRKYTAVVHGLISHDDGTIDAPIGRDKKDRQSMTVTRDGKNAVTHFHVLERF QDFTLVECQLETGRTHQIRVHMKYIGFPLAGDPKYGPRKTIDFNGQALHAGVLGFDHP RTGEYVEFEAPLPEDMAELIENLRKNG*" /label="rluD CDS" gene 1529538..1530449 /gene="rluD" /locus_tag="BSU_15460" /old_locus_tag="BSU15460" /label="rluD gene" promotor_-35 1530444..1530451 /Source="Nicolas_upshift_promotors" /id="U1288" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.785214785214785" /psig=1 /xcortree=2423 /SigmaFactorBS="ttaatcgaaaacctcagaaaaaacGGTTGACAgagggtttct tttcTGAAATAATAAACGAAGCTGaatagattctttaaaacagtccagagaggctgag a" /listShort="NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE, S568" /listLong="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /label="promotor_-35" promotor_-10 1530466..1530485 /Source="Nicolas_upshift_promotors" /id="U1288" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.785214785214785" /psig=1 /xcortree=2423 /SigmaFactorBS="ttaatcgaaaacctcagaaaaaacGGTTGACAgagggtttct tttcTGAAATAATAAACGAAGCTGaatagattctttaaaacagtccagagaggctgag a" /listShort="NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE, S568" /listLong="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /label="promotor_-10" upshifts 1530480 /Source="Nicolas_upshifts" /id="U1288" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.785214785214785" /psig=1 /xcortree=2423 /SigmaFactorBS="ttaatcgaaaacctcagaaaaaacGGTTGACAgagggtttct tttcTGAAATAATAAACGAAGCTGaatagattctttaaaacagtccagagaggctgag a" /listShort="NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE, S568" /listLong="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /label="upshifts" misc_RNA 1530489..1530605 /gene="pyaA" /locus_tag="BSU_misc_RNA_26" /product="pyrimidine biosynthesis operon attenuator" /experiment="publication(s) with functional evidences, PMID:7868607, 8206849, 8636037, 8955403, 9488732, 9932459, 11726695, 12787499, 15252202" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7868607, 8206849, 8636037, 8955403, 9488732, 9932459, 11726695, 12787499, 15252202; Product type n: RNA" /label="pyaA RNA" gene 1530489..1530605 /gene="pyaA" /locus_tag="BSU_misc_RNA_26" /label="pyaA gene" CDS 1530632..1531177 /gene="pyrR" /locus_tag="BSU_15470" /old_locus_tag="BSU15470" /EC_number="2.4.2.9" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7798145, 9932459, 12482852, 15716449, 17322189, 18678934" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7798145, 9932459, 12482852, 15716449, 17322189, 18678934; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional attenuator and uracil phosphoribosyltransferase activity" /protein_id="NP_389430.1" /db_xref="EnsemblGenomes-Gn:BSU15470" /db_xref="EnsemblGenomes-Tr:CAB13421" /db_xref="GOA:P39765" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR023050" /db_xref="InterPro:IPR029057" /db_xref="PDB:1A3C" /db_xref="PDB:1A4X" /db_xref="PDB:4P82" /db_xref="SubtiList:BG10712" /db_xref="UniProtKB/Swiss-Prot:P39765" /translation="MNQKAVILDEQAIRRALTRIAHEMIERNKGMNNCILVGIKTRGI YLAKRLAERIEQIEGNPVTVGEIDITLYRDDLSKKTSNDEPLVKGADIPVDITDQKVI LVDDVLYTGRTVRAGMDALVDVGRPSSIQLAVLVDRGHRELPIRADYIGKNIPTSKSE KVMVQLDEVDQNDLVAIYENE*" /label="pyrR CDS" gene 1530632..1531177 /gene="pyrR" /locus_tag="BSU_15470" /old_locus_tag="BSU15470" /label="pyrR gene" downshifts complement(1530826) /Source="Nicolas_upshifts" /id="D872" /incds=1 /nref=1 /ntot=47 /MaxReadThrough="1.85132" /MaxDrop="2.50006" /score="0.812637138" /energy="-7" /TU="NA" /idTUdmin="U1275" /TUdmin="-14864" /isTUend="FALSE" /label="downshifts" downshifts 1531168 /Source="Nicolas_upshifts" /id="D873" /incds=0 /nref=13 /ntot=149 /MaxReadThrough="8.16191" /MaxDrop="3.4492" /score="16.3570883" /energy="-11.5" /TU="U1287,U1288" /idTUdmin="U1286" /TUdmin=704 /isTUend="FALSE" /label="downshifts" misc_RNA 1531181..1531298 /gene="pyaB" /locus_tag="BSU_misc_RNA_27" /product="pyrimidine biosynthesis operon attenuator" /experiment="publication(s) with functional evidences, PMID:7868607, 8206849, 8636037, 8955403, 9488732, 9932459, 11726695, 12787499, 15252202" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7868607, 8206849, 8636037, 8955403, 9488732, 9932459, 11726695, 12787499, 15252202; Product type n: RNA" /label="pyaB RNA" gene 1531181..1531298 /gene="pyaB" /locus_tag="BSU_misc_RNA_27" /label="pyaB gene" CDS 1531351..1532658 /gene="pyrP" /locus_tag="BSU_15480" /old_locus_tag="BSU15480" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 8206848, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="uracil permease" /protein_id="NP_389431.2" /db_xref="EnsemblGenomes-Gn:BSU15480" /db_xref="EnsemblGenomes-Tr:CAB13422" /db_xref="GOA:P39766" /db_xref="InterPro:IPR006042" /db_xref="InterPro:IPR006043" /db_xref="InterPro:IPR029935" /db_xref="SubtiList:BG10992" /db_xref="UniProtKB/Swiss-Prot:P39766" /translation="MSKKKVNLGVRDVPTPFSWVSFSLQHLFAMFGSTILVPKLVGMS PAVALVTSGIGTLAYLLITKGQIPAYLGSSFAFISPIILVKATGGPGAAMVGAFLAGL VYGLIALLIRQLGTGWLMKILPPVVVGPVIIVIGLGLASTAVNMAMYADPNASELVYS LKHFSVAGVTLAITIICAIFLRGFLSLIPVLIGIIGGYLFALTQGIVNFQPVLDAKWF AVPEFIIPFKDYSPSVTLGIAAAMVPVAFVTMSEHIGHQMVLSKVVGQDFIKKPGLHR SIMGDSVATILASLIGGPPTTTYGENIGVLAITRVFSVFVIGGAAVIALCFGFIGKIS ALISSVPSAVMGGVSFLLFGIIASSGLRMLIDNKIDYENNRNLIITSVILVIGVGGAF IQVSQGGFQVSGMALAAIVGVILNLILPQAKEEQADTSEQHHI*" /label="pyrP CDS" gene 1531351..1532658 /gene="pyrP" /locus_tag="BSU_15480" /old_locus_tag="BSU15480" /label="pyrP gene" misc_RNA 1532659..1532773 /gene="pyaC" /locus_tag="BSU_misc_RNA_28" /product="pyrimidine biosynthesis operon attenuator" /experiment="publication(s) with functional evidences, PMID:7868607, 8206849, 8636037, 8955403, 9488732, 9932459, 11726695, 12787499, 15252202" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7868607, 8206849, 8636037, 8955403, 9488732, 9932459, 11726695, 12787499, 15252202; Product type n: RNA" /label="pyaC RNA" gene 1532659..1532773 /gene="pyaC" /locus_tag="BSU_misc_RNA_28" /label="pyaC gene" CDS 1532804..1533718 /gene="pyrB" /locus_tag="BSU_15490" /old_locus_tag="BSU15490" /EC_number="2.1.3.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8535162, 16321950, 21663747" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8535162, 16321950, 21663747; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aspartate carbamoyltransferase" /protein_id="NP_389432.2" /db_xref="EnsemblGenomes-Gn:BSU15490" /db_xref="EnsemblGenomes-Tr:CAB13423" /db_xref="GOA:P05654" /db_xref="InterPro:IPR002082" /db_xref="InterPro:IPR006130" /db_xref="InterPro:IPR006131" /db_xref="InterPro:IPR006132" /db_xref="InterPro:IPR036901" /db_xref="PDB:2AT2" /db_xref="PDB:3R7D" /db_xref="PDB:3R7F" /db_xref="PDB:3R7L" /db_xref="SubtiList:BG10713" /db_xref="UniProtKB/Swiss-Prot:P05654" /translation="MKHLTTMSELSTEEIKDLLQTAQELKSGKTDNQLTGKFAANLFF EPSTRTRFSFEVAEKKLGMNVLNLDGTSTSVQKGETLYDTIRTLESIGVDVCVIRHSE DEYYEELVSQVNIPILNAGDGCGQHPTQSLLDLMTIYEEFNTFKGLTVSIHGDIKHSR VARSNAEVLTRLGARVLFSGPSEWQDEENTFGTYVSMDEAVESSDVVMLLRIQNERHQ SAVSQEGYLNKYGLTVERAERMKRHAIIMHPAPVNRGVEIDDSLVESEKSRIFKQMKN GVFIRMAVIQRALQTNVKRGEAAYVISH*" /label="pyrB CDS" gene 1532804..1533718 /gene="pyrB" /locus_tag="BSU_15490" /old_locus_tag="BSU15490" /label="pyrB gene" CDS 1533702..1534988 /gene="pyrC" /locus_tag="BSU_15500" /old_locus_tag="BSU15500" /EC_number="3.5.2.3" /function="2: Purines, pyrimidines, nucleosides, and nucleotides" /experiment="publication(s) with functional evidences, PMID:7516791, 16522191, 21045288" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7516791, 16522191, 21045288; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydroorotase" /protein_id="NP_389433.2" /db_xref="EnsemblGenomes-Gn:BSU15500" /db_xref="EnsemblGenomes-Tr:CAB13424" /db_xref="GOA:P25995" /db_xref="InterPro:IPR002195" /db_xref="InterPro:IPR004722" /db_xref="InterPro:IPR006680" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR032466" /db_xref="SubtiList:BG10714" /db_xref="UniProtKB/Swiss-Prot:P25995" /translation="MSYLIKNGWILNENGEKTQADIRVTGETITAIGKLDATDNETVI DAKGLLVSPGFVDLHVHFREPGGEKKETIETGAKAAARGGYTTVAAMPNTRPVPDTKE QMEWVQNRIKETSCVRVLPYASITIRQIGDEMTNFEALKEAGAFAFTDDGVGIQTAGM MYEAMKRAAAIDKAIVAHCEDNSLIYGGSVHEGTFSKANGLNGIPSVCESVHIARDVL LAEAANCHYHVCHISTKESVRVVRDAKKAGIRVTAEVSPHHLLLCDEDIPGLDTNYKM NPPLRSPEDRAALIEGLLDGTIDFIATDHAPHTEEEKNTEMKLAPFGIVGLETAFPLL YTHFVKNGSWSLKQLIDYMTIKPCEAFGLPYGTLQTGQAADITLIDLEKEAVIDKETF LSKGKNTPFNGISCTGWPVATIAAGKLAYEEGRLVK*" /label="pyrC CDS" gene 1533702..1534988 /gene="pyrC" /locus_tag="BSU_15500" /old_locus_tag="BSU15500" /label="pyrC gene" CDS 1534985..1536079 /gene="pyrAA" /locus_tag="BSU_15510" /old_locus_tag="BSU15510" /EC_number="6.3.5.5" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1709162, 11390694, 23750951; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyrimidine-specific carbamoyl-phosphate synthetase (small subunit, glutaminase subunit)" /protein_id="NP_389434.1" /db_xref="EnsemblGenomes-Gn:BSU15510" /db_xref="EnsemblGenomes-Tr:CAB13425" /db_xref="GOA:P25993" /db_xref="InterPro:IPR002474" /db_xref="InterPro:IPR006274" /db_xref="InterPro:IPR017926" /db_xref="InterPro:IPR029062" /db_xref="InterPro:IPR035686" /db_xref="InterPro:IPR036480" /db_xref="SubtiList:BG10715" /db_xref="UniProtKB/Swiss-Prot:P25993" /translation="MKRRLVLENGAVFEGEAFGSLEHNMGEVVFNTGMTGYQEILSDP SYCGQIVTLTYPLIGNYGINRDDFESITPFVKGLIIKELCELPSNWRSAYTLDEYLKM KNIPGLQGIDTRKLTRMIRTAGALKGTFASSDEDIEAVLKRLNETELPRNQVSQVSAK TAYPSPGRGKRIVLVDFGMKHGILRELNKRKCDVIVVPYNITAEEVLQLKPDGIMLSN GPGDPKDVPEAIEMIKGVLGKVPLFGICLGHQLFALACGANTEKMKFGHRGSNHPVKE LATGKVALTSQNHGYTVSSISKTELEVTHIAINDDTIEGLKHKTLPAFTVQYHPEASP GPEDANHLFDRFIEMIETTEKEGEAVCQNA*" /label="pyrAA CDS" gene 1534985..1536079 /gene="pyrAA" /locus_tag="BSU_15510" /old_locus_tag="BSU15510" /label="pyrAA gene" CDS 1536064..1539279 /gene="pyrAB" /locus_tag="BSU_15520" /old_locus_tag="BSU15520" /EC_number="6.3.5.5" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 216664, 6120161, 10732707, 23750951; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyrimidine-specific carbamoyl-phosphate synthetase (large subunit)" /protein_id="NP_389435.1" /db_xref="EnsemblGenomes-Gn:BSU15520" /db_xref="EnsemblGenomes-Tr:CAB13426" /db_xref="GOA:P25994" /db_xref="InterPro:IPR005479" /db_xref="InterPro:IPR005480" /db_xref="InterPro:IPR005483" /db_xref="InterPro:IPR006275" /db_xref="InterPro:IPR011607" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="InterPro:IPR033937" /db_xref="InterPro:IPR036897" /db_xref="InterPro:IPR036914" /db_xref="SubtiList:BG10716" /db_xref="UniProtKB/Swiss-Prot:P25994" /translation="MPKRVDINKILVIGSGPIIIGQAAEFDYAGTQACLALKEEGYEV ILVNSNPATIMTDTEMADRVYIEPLTPEFLTRIIRKERPDAILPTLGGQTGLNLAVEL SERGVLAECGVEVLGTKLSAIQQAEDRDLFRTLMNELNEPVPESEIIHSLEEAEKFVS QIGFPVIVRPAYTLGGTGGGICSNETELKEIVENGLKLSPVHQCLLEKSIAGYKEIEY EVMRDSQDHAIVVCNMENIDPVGIHTGDSIVVAPSQTLSDREYQLLRNVSLKLIRALG IEGGCNVQLALDPDSFQYYIIEVNPRVSRSSALASKATGYPIAKLAAKIAVGLSLDEM MNPVTGKTYAAFEPALDYVVSKIPRWPFDKFESANRKLGTQMKATGEVMAIGRTLEES LLKAVRSLEADVYHLELKDAADISDELLEKRIKKAGDERLFYLAEAYRRGYTVEDLHE FSAIDVFFLHKLFGIVQFEKELKANAGDTDVLRRAKELGFSDQYISREWKMKESELYS LRKQAGIAPVFKMVDTCAAEFESETPYFYSTYEEENESVVTDKKSVMVLGSGPIRIGQ GVEFDYATVHSVWAIKQAGYEAIIVNNNPETVSTDFSISDKLYFEPLTIEDVMHIIDL EQPMGVVVQFGGQTAINLADELSARGVKILGTSLEDLDRAEDRDKFEQALGELGVPQP LGKTATSVNQAVSIASDIGYPVLVRPSYVLGGRAMEIVYHEEELLHYMKNAVKINPQH PVLIDRYLTGKEIEVDAVSDGETVVIPGIMEHIERAGVHSGDSIAVYPPQSLTEDIKK KIEQYTIALAKGLNIVGLLNIQFVLSQGEVYVLEVNPRSSRTVPFLSKITGIPMANLA TKIILGQKLAAFGYTEGLQPEQQGVFVKAPVFSFAKLRRVDITLGPEMKSTGEVMGKD STLEKALYKALIASGIQIPNYGSVLLTVADKDKEEGLAIAKRFHAIGYNILATEGTAG YLKEASIPAKVVGKIGQDGPNLLDVIRNGEAQFVINTLTKGKQPARDGFRIRRESVEN GVACLTSLDTAEAILRVLESMTFRADQMPAVNTNQEAAVTI*" /label="pyrAB CDS" gene 1536064..1539279 /gene="pyrAB" /locus_tag="BSU_15520" /old_locus_tag="BSU15520" /label="pyrAB gene" CDS 1539276..1540046 /gene="pyrK" /locus_tag="BSU_15530" /old_locus_tag="BSU15530" /EC_number="1.3.98.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:169225, 10545205, 11188687, 15299876" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 169225, 10545205, 11188687, 15299876; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydroorotate dehydrogenase (electron transfer subunit)" /protein_id="NP_389436.1" /db_xref="EnsemblGenomes-Gn:BSU15530" /db_xref="EnsemblGenomes-Tr:CAB13427" /db_xref="GOA:P25983" /db_xref="InterPro:IPR001433" /db_xref="InterPro:IPR012165" /db_xref="InterPro:IPR017927" /db_xref="InterPro:IPR017938" /db_xref="InterPro:IPR019480" /db_xref="InterPro:IPR023455" /db_xref="InterPro:IPR037117" /db_xref="SubtiList:BG10717" /db_xref="UniProtKB/Swiss-Prot:P25983" /translation="MKKAYLTVCSNQQIADRVFQMVLKGELVQGFTTPGQFLHLKVSE AVTPLLRRPISIADVNFEKNEVTIIYRVDGEGTRLLSLKQQGELVDVLGPLGNGFPVN EVQPGKTALLVGGGVGVPPLQELSKRLIEKGVNVIHVLGFQSAKDVFYEEECRQYGDT YVATADGSYGETGFVTDVIKRKKLEFDILLSCGPTPMLKALKQEYAHKEVYLSMEERM GCGIGACFACVCHTNESETSYVKVCLDGPVFKAQEVAL*" /label="pyrK CDS" gene 1539276..1540046 /gene="pyrK" /locus_tag="BSU_15530" /old_locus_tag="BSU15530" /label="pyrK gene" CDS 1540046..1540981 /gene="pyrD" /locus_tag="BSU_15540" /old_locus_tag="BSU15540" /EC_number="1.3.1.15" /experiment="publication(s) with functional evidences, PMID:4380263, 10545205" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4380263, 10545205; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydroorotate dehydrogenase (catalytic subunit)" /protein_id="NP_389437.1" /db_xref="EnsemblGenomes-Gn:BSU15540" /db_xref="EnsemblGenomes-Tr:CAB13428" /db_xref="GOA:P25996" /db_xref="InterPro:IPR001295" /db_xref="InterPro:IPR005720" /db_xref="InterPro:IPR012135" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR024920" /db_xref="InterPro:IPR033888" /db_xref="SubtiList:BG10718" /db_xref="UniProtKB/Swiss-Prot:P25996" /translation="MLEVKLPGLDLKNPIIPASGCFGFGKEFSRFYDLSCLGAIMIKA TTKEPRFGNPTPRVAETGAGMLNAIGLQNPGLDSVLHHELPWLEQFDTPIIANVAGSQ VDDYVEVAEHISKAPNVHALELNISCPNVKTGGIAFGTNPEMAADLTKAVKEVSDVPV YVKLSPNVANITEIALAIEEAGADGLTMINTLIGMRLDLKTGKPILANKTGGLSGPAV KPVAIRMVYEVSQMVNIPIIGMGGVQTAEDALEFLLAGASAVAVGTANFVNPFACPEI IEQLPSVLLQYGYQSIEECIGRSWNHEKQPAHHRA*" /label="pyrD CDS" gene 1540046..1540981 /gene="pyrD" /locus_tag="BSU_15540" /old_locus_tag="BSU15540" /label="pyrD gene" CDS 1540950..1541669 /gene="pyrF" /locus_tag="BSU_15550" /old_locus_tag="BSU15550" /EC_number="4.1.1.23" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10681442, 11390694, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10681442, 11390694, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="orotidine 5'-phosphate decarboxylase" /protein_id="NP_389438.1" /db_xref="EnsemblGenomes-Gn:BSU15550" /db_xref="EnsemblGenomes-Tr:CAB13429" /db_xref="GOA:P25971" /db_xref="InterPro:IPR001754" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR014732" /db_xref="InterPro:IPR018089" /db_xref="PDB:1DBT" /db_xref="SubtiList:BG10719" /db_xref="UniProtKB/Swiss-Prot:P25971" /translation="MKNNLPIIALDFASAEETLAFLAPFQQEPLFVKVGMELFYQEGP SIVKQLKERNCELFLDLKLHDIPTTVNKAMKRLASLGVDLVNVHAAGGKKMMQAALEG LEEGTPAGKKRPSLIAVTQLTSTSEQIMKDELLIEKSLIDTVVHYSKQAEESGLDGVV CSVHEAKAIYQAVSPSFLTVTPGIRMSEDAANDQVRVATPAIAREKGSSAIVVGRSIT KAEDPVKAYKAVRLEWEGIKS*" /label="pyrF CDS" gene 1540950..1541669 /gene="pyrF" /locus_tag="BSU_15550" /old_locus_tag="BSU15550" /label="pyrF gene" CDS 1541648..1542298 /gene="pyrE" /locus_tag="BSU_15560" /old_locus_tag="BSU15560" /EC_number="2.4.2.10" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9305779, 22447609, 23405251; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="orotate phosphoribosyltransferase" /protein_id="NP_389439.1" /db_xref="EnsemblGenomes-Gn:BSU15560" /db_xref="EnsemblGenomes-Tr:CAB13430" /db_xref="GOA:P25972" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR004467" /db_xref="InterPro:IPR023031" /db_xref="InterPro:IPR029057" /db_xref="SubtiList:BG10720" /db_xref="UniProtKB/Swiss-Prot:P25972" /translation="MGGNQILKQIIAKHLLDIQAVFLRPNEPFTWASGILSPIYCDNR LTLSFPEVRNDVASGISKLVKEHFPEAEMIAGTATAGIPHAALAADHLNLPMCYVRSK PKAHGKGNQIEGAVQEGQKTVVIEDLISTGGSVLEACAALQAAGCEVLGVVSIFTYGL PKAEEAFAKAELPYYSLTDYDTLTEVALENGNIHSDDLKKLQTWKRNPESKDWFKK*" /label="pyrE CDS" gene 1541648..1542298 /gene="pyrE" /locus_tag="BSU_15560" /old_locus_tag="BSU15560" /label="pyrE gene" downshifts 1542300 /Source="Nicolas_upshifts" /id="D874" /incds=0 /nref=17 /ntot=184 /MaxReadThrough="3.91018" /MaxDrop="5.49939" /score="33.4515727" /energy="-9" /TU="U1287,U1288" /idTUdmin="U1287" /TUdmin="-115" /isTUend="FALSE" /label="downshifts" S_feature 1542345..1542417 /Source="Nicolas_S_feature" /locus_tag="new_1630017_1630089" /HighExp="Cold, Gly, MG 5, S0, LPh, M/G, GM 60, MG t5, Mal, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S568" promotor_-35 1542397..1542404 /Source="Nicolas_upshift_promotors" /id="U1289" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig=1 /xcortree=2889 /SigmaFactorBS="tgaggcctgtttttttattaatcctataaaaaaagtcgGGTT GACTtatgttagaattgTGCTAAAATTTACTACAAATctaaaaacttatcaagagcgg c" /listShort="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1542418..1542437 /Source="Nicolas_upshift_promotors" /id="U1289" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig=1 /xcortree=2889 /SigmaFactorBS="tgaggcctgtttttttattaatcctataaaaaaagtcgGGTT GACTtatgttagaattgTGCTAAAATTTACTACAAATctaaaaacttatcaagagcgg c" /listShort="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1542419 /Source="Nicolas_upshifts" /id="U1289" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig=1 /xcortree=2889 /SigmaFactorBS="tgaggcctgtttttttattaatcctataaaaaaagtcgGGTT GACTtatgttagaattgTGCTAAAATTTACTACAAATctaaaaacttatcaagagcgg c" /listShort="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 1542443..1542548 /gene="mswE" /locus_tag="BSU_misc_RNA_29" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /label="mswE RNA" gene 1542443..1542548 /gene="mswE" /locus_tag="BSU_misc_RNA_29" /label="mswE gene" S_feature 1542549..1542709 /Source="Nicolas_S_feature" /locus_tag="new_1630221_1630381" /HighExp="MG 10, B60, MG 5, MG t5, M9-exp, MG 25, MG 60, MG 15, GM 90, GM 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S569" CDS 1542710..1543411 /gene="cysH" /locus_tag="BSU_15570" /old_locus_tag="BSU15570" /EC_number="1.8.4.8" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10094622, 11004190, 12072441, 16267287, 18456801" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 11004190, 12072441, 16267287, 18456801; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="(phospho)adenosine phosphosulfate reductase" /protein_id="NP_389440.1" /db_xref="EnsemblGenomes-Gn:BSU15570" /db_xref="EnsemblGenomes-Tr:CAB13431" /db_xref="GOA:P94498" /db_xref="InterPro:IPR002500" /db_xref="InterPro:IPR004511" /db_xref="InterPro:IPR011798" /db_xref="InterPro:IPR014729" /db_xref="SubtiList:BG11930" /db_xref="UniProtKB/Swiss-Prot:P94498" /translation="MLTYDNWEEPTITFPEDDPYKGALSVLKWAYGHYGDQLVYACSF GIEGIVLIDLIYKVKKDAEIVFLDTGLHFKETYETIERVKERYPGLNIILKKPDLTLE EQAEEHGDKLWEREPNQCCYLRKVVPLREALSGHPAWLSGLRRDQGPSRANTNFLNKD EKFKSVKVCPLIHWTWKDIWRYTSRNELDYNPLHDQGYPSIGCAPCTSPAFTAEDLRS GRWNGMAKTECGLHE*" /label="cysH CDS" gene 1542710..1543411 /gene="cysH" /locus_tag="BSU_15570" /old_locus_tag="BSU15570" /label="cysH gene" CDS 1543423..1544487 /gene="cysP" /locus_tag="BSU_15580" /old_locus_tag="BSU15580" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10094622, 10784039, 11004190, 15849754, 16850406, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 10784039, 11004190, 15849754, 16850406, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="sulfate permease" /protein_id="NP_389441.1" /db_xref="EnsemblGenomes-Gn:BSU15580" /db_xref="EnsemblGenomes-Tr:CAB13432" /db_xref="GOA:O34734" /db_xref="InterPro:IPR001204" /db_xref="SubtiList:BG13377" /db_xref="UniProtKB/Swiss-Prot:O34734" /translation="MELAAILFSLFFAMNIGASGAAASMGVAYGSGAIKKKTYALILC AVGVFAGAVIGGGEVVKTISSGIIPEQTITLTIVCIIIGAAALSLFTANLLGIPLSTS EVTVGAVVGVGVAYKVLFVNNLLIIVSFWVFVPLFAFGFTYFVSKLFRYFKIEVKSSK KQKILGIVLLVAGFFEAFSAGMNNVANAVGPLVAAGVLDVGKGTLYGGAFVALGALLL GRRVLETNGKKITRFSKGEGILLSGTGAGLVIISSVFGMPVPLAQVTSSSIIGIGMAK NGPNVFHKQVVQTMLKVWIVSPFLSLSISYLLVSLFLKADYYSIFIMVSVLLAAGGAI SLTKAIRKERRSVHEQGGGI*" /label="cysP CDS" gene 1543423..1544487 /gene="cysP" /locus_tag="BSU_15580" /old_locus_tag="BSU15580" /label="cysP gene" CDS 1544536..1545684 /gene="sat" /locus_tag="BSU_15590" /old_locus_tag="BSU15590" /EC_number="2.7.7.4" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10094622, 11004190, 11274114; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sulfate adenylyltransferase" /protein_id="NP_389442.1" /db_xref="EnsemblGenomes-Gn:BSU15590" /db_xref="EnsemblGenomes-Tr:CAB13433" /db_xref="GOA:O34764" /db_xref="InterPro:IPR002650" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR020792" /db_xref="InterPro:IPR024951" /db_xref="InterPro:IPR025980" /db_xref="SubtiList:BG13378" /db_xref="UniProtKB/Swiss-Prot:O34764" /translation="MSLAPHGGTLVNRVDESYDVSGIQKEIELDLISFADLELIGIGA YSPIEGFFNEKDYVSVVENMRLSSGVVWSLPITLPVDAQKAAELSLGETVKLTYEGET YGVIQIEDLYVPDKQKEAVNVYKTDEQEHPGVKKLFSRGNTYVGGPITLIKKASKQFP EFTFEPSETRRQFAEKGWETIVGFQTRNPVHRAHEYIQKTALETVDGLFLNPLVGETK SDDIPADVRMESYQVLLDHYYPKDRVFLGVFLAAMRYAGPREAIFHALVRKNYGCTHF IVGRDHAGVGDYYGTYEAQELFDTFKPEELGITPLKFEHSFFCKKCGNMGTAKTCPHG REHHVILSGTKVRGMLRDGVLPPAEFSRKEVVEVLIKGMKKKEEVGVS*" /label="sat CDS" gene 1544536..1545684 /gene="sat" /locus_tag="BSU_15590" /old_locus_tag="BSU15590" /label="sat gene" upshifts complement(1544625) /Source="Nicolas_upshifts" /id="U1290" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.978021978021978" /psig="0.007992007992008" /xcortree=27 /SigmaFactorBS="accttcaatcgggctgtatgcaccgATaccgatcaattccaa atCCGCGaaagaaattaaatcaagttcaatttctttttgaatgccgctcacatcatat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1544637..1544641) /Source="Nicolas_upshift_promotors" /id="U1290" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.978021978021978" /psig="0.007992007992008" /xcortree=27 /SigmaFactorBS="accttcaatcgggctgtatgcaccgATaccgatcaattccaa atCCGCGaaagaaattaaatcaagttcaatttctttttgaatgccgctcacatcatat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1544659..1544660) /Source="Nicolas_upshift_promotors" /id="U1290" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.978021978021978" /psig="0.007992007992008" /xcortree=27 /SigmaFactorBS="accttcaatcgggctgtatgcaccgATaccgatcaattccaa atCCGCGaaagaaattaaatcaagttcaatttctttttgaatgccgctcacatcatat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1545697..1546290 /gene="cysC" /locus_tag="BSU_15600" /old_locus_tag="BSU15600" /EC_number="2.7.1.25" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1332767, 10094622, 11004190, 19067028, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="adenylylsulfate kinase" /protein_id="NP_389443.1" /db_xref="EnsemblGenomes-Gn:BSU15600" /db_xref="EnsemblGenomes-Tr:CAB13434" /db_xref="GOA:O34577" /db_xref="InterPro:IPR002891" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13379" /db_xref="UniProtKB/Swiss-Prot:O34577" /translation="MTNRDIVWHEASITKEEYQQKNKHKSSILWLTGLSGSGKSTIAN AAARELFEQGYQVIVLDGDNIRHGLNRDLGFSDEDRKENIRRIGEVAKLFVQQGTIVI TAFISPFREDRQQVRELVEAGEFNEVYIKCDLDICEQRDPKGLYKKARNGEIPFFTGI DSPYEEPEAPELVLDSGQHDREACKNQLIEFVKQKLS*" /label="cysC CDS" gene 1545697..1546290 /gene="cysC" /locus_tag="BSU_15600" /old_locus_tag="BSU15600" /label="cysC gene" S_feature 1546291..1546388 /Source="Nicolas_S_feature" /locus_tag="new_1633963_1634060" /HighExp="MG 10, B36, MG 5, MG t5, B60, MG 15, MG 90, MG-0.2, MG 60, MG 45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S570" CDS 1546389..1547162 /gene="sumT" /locus_tag="BSU_15610" /old_locus_tag="BSU15610" /EC_number="2.1.1.107" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1906874, 11004190, 10094622, 19154787; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="uroporphyrinogen III and precorrin-1 C-methyltransferase" /protein_id="NP_389444.1" /db_xref="EnsemblGenomes-Gn:BSU15610" /db_xref="EnsemblGenomes-Tr:CAB13435" /db_xref="GOA:O34744" /db_xref="InterPro:IPR000878" /db_xref="InterPro:IPR003043" /db_xref="InterPro:IPR006366" /db_xref="InterPro:IPR014776" /db_xref="InterPro:IPR014777" /db_xref="InterPro:IPR035996" /db_xref="SubtiList:BG13380" /db_xref="UniProtKB/Swiss-Prot:O34744" /translation="MGKVYIVGAGPGDPDLLTIKALKAIEKADVILYDRLVNKEILQY AKEQADLIYCGKLPDFHTMKQETINRFLVKYAQKGKMVVRLKGGDPFVFGRGGEEAEC LSENGIPFEIIPGITSGIAAAAYAGIPVTHRDAGSNVAFVTGHYKKEEDFEEKWKALA TGIDTLVIYMGIKNVQQIERKLLENGRDGSTPAAFIHWGTTDKQKSVFCTVDTLSETV IKENITNPSLIVIGNVVNYHYKLEWFESELKKQDLSEAL*" /label="sumT CDS" gene 1546389..1547162 /gene="sumT" /locus_tag="BSU_15610" /old_locus_tag="BSU15610" /label="sumT gene" promotor_-35 1547067..1547074 /Source="Nicolas_upshift_promotors" /id="U1291" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.763236763236763" /psig=1 /xcortree=1738 /SigmaFactorBS="ttcagaaacggtgataaaagaaaacattacaaatccgAGTTT AATtgtcattggaaatgTTGTAAATTATCACTATAAGctggaatggtttgaatctgaa c" /listShort="sirB, sirC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1547089..1547108 /Source="Nicolas_upshift_promotors" /id="U1291" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.763236763236763" /psig=1 /xcortree=1738 /SigmaFactorBS="ttcagaaacggtgataaaagaaaacattacaaatccgAGTTT AATtgtcattggaaatgTTGTAAATTATCACTATAAGctggaatggtttgaatctgaa c" /listShort="sirB, sirC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1547090 /Source="Nicolas_upshifts" /id="U1291" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.763236763236763" /psig=1 /xcortree=1738 /SigmaFactorBS="ttcagaaacggtgataaaagaaaacattacaaatccgAGTTT AATtgtcattggaaatgTTGTAAATTATCACTATAAGctggaatggtttgaatctgaa c" /listShort="sirB, sirC" /GFF_Attribute="listLong" /label="upshifts" CDS 1547165..1547950 /gene="sirB" /locus_tag="BSU_15620" /old_locus_tag="BSU15620" /EC_number="4.99.1.4" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 10094622, 11004190, 12408752; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sirohydrochlorin ferrochelatase" /protein_id="NP_389445.1" /db_xref="EnsemblGenomes-Gn:BSU15620" /db_xref="EnsemblGenomes-Tr:CAB13436" /db_xref="GOA:O34632" /db_xref="InterPro:IPR002762" /db_xref="SubtiList:BG13381" /db_xref="UniProtKB/Swiss-Prot:O34632" /translation="MKQAILYVGHGSRVKKAQQEAAAFLEGCKAHISVPVQEISFLEL QEPTIETGFEACVKQGATHIAVVPLLLLTAAHAKHDIPEEIVRVASRYPSVRISYGKP IGIDEEVVKAVYHRMKDIGVPYENARVVLIGRGSSDPDVKRDVTGIANLLQEMVPVKE VIPCFLTACGPNYKEVFSELEKDDGITTFIVPYLLFTGMLMNEIEREVQKLKAHNPNV YLSSYIGFHPHVKNAFLNRVRETAANSEGQFDFDGGSYASAAH*" /label="sirB CDS" gene 1547165..1547950 /gene="sirB" /locus_tag="BSU_15620" /old_locus_tag="BSU15620" /label="sirB gene" CDS 1547931..1548419 /gene="sirC" /locus_tag="BSU_15630" /old_locus_tag="BSU15630" /EC_number="1.3.1.76" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 10094622, 11004190, 12408752, 18588505; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="precorrin-2 dehydrogenase" /protein_id="NP_389446.1" /db_xref="EnsemblGenomes-Gn:BSU15630" /db_xref="EnsemblGenomes-Tr:CAB13437" /db_xref="GOA:O34813" /db_xref="InterPro:IPR006367" /db_xref="InterPro:IPR028161" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13382" /db_xref="UniProtKB/Swiss-Prot:O34813" /translation="MLPLHISLEKKKVVIAGGGSIALRRLKTVISEGADITLVSPDVE PEIKQMAEERRIKWEKRTIEKEDYLNAFFIIAATDNAAVNKEIAQSASPFQLVNCVSD AELGNVYMPKIVKRGHVTVSVSTSGASPKHTKELAENVDKLIDGDFVAEVNRLYQMRR KK*" /label="sirC CDS" gene 1547931..1548419 /gene="sirC" /locus_tag="BSU_15630" /old_locus_tag="BSU15630" /label="sirC gene" downshifts 1548399 /Source="Nicolas_upshifts" /id="D875" /incds=0 /nref=256 /ntot=267 /MaxReadThrough="2.85828" /MaxDrop="8.90139" /score="26.5923498" /energy="-16.6" /TU="U1289" /idTUdmin="U1291" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1548446) /Source="Nicolas_upshifts" /id="D876" /incds=0 /nref=149 /ntot=238 /MaxReadThrough="1.71588" /MaxDrop="5.36964" /score="15.559144" /energy="-16.6" /TU="NA" /idTUdmin="U1292" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS complement(1548459..1550177) /gene="fbnA" /locus_tag="BSU_15640" /old_locus_tag="BSU15640" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 11238985, 17586671, 24646681, 28294433; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative tRNA modification protein" /protein_id="NP_389447.1" /db_xref="EnsemblGenomes-Gn:BSU15640" /db_xref="EnsemblGenomes-Tr:CAB13438" /db_xref="InterPro:IPR008532" /db_xref="SubtiList:BG13383" /db_xref="UniProtKB/Swiss-Prot:O34693" /translation="MHMSFDGMFTYGMTHELNEKIMGGRITKIHQPYKHDVIFHIRAK GKNQKLLLSAHPSYSRVHITAQAYENPSEPPMFCMLLRKHIEGGFIEKIEQAGLDRIM IFHIKSRNEIGDETVRKLYVEIMGRHSNIILTDAAENVIIDGLKHLSPSMNSYRTVLP GQDYKLPPAQDKISPLEASEDDILRHLSFQEGRLDKQIVDHFSGVSPLFAKEAVHRAG LANKVTLPKALLALFAEVKEHRFIPNITTVNGKEYFYLLELTHLKGEARRFDSLSELL DRFYFGKAERDRVKQQAQDLERFVVNERKKNANKIKKLEKTLEYSENAKEFQLYGELL TANLYMLKKGDKQAEVINYYDEESPTITIPLNPNKTPSENAQAYFTKYQKAKNSVAVV EEQIRLAQEEIEYFDQLIQQLSSASPRDISEIREELVEGKYLRPKQQKGQKKQKPHNP VLETYESTSGLTILVGKNNRQNEYLTTRVAARDDIWLHTKDIPGSHVVIRSSEPDEQT IMEAATIAAYFSKAKDSSSVPVDYTKIRHVKKPNGAKPGFVTYDSQHTVFVTPDADTV IKLKKS*" /label="fbnA CDS" gene complement(1548459..1550177) /gene="fbnA" /locus_tag="BSU_15640" /old_locus_tag="BSU15640" /label="fbnA gene" promotor_-10 complement(1550199..1550218) /Source="Nicolas_upshift_promotors" /id="U1292" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.766233766233766" /psig="0.999000999001" /xcortree=2006 /SigmaFactorBS="gctctcttatagagatatcactctataagcatgcttaTTCTG ActcgtcccatttCATGCTATAATTATCGAATGcaggaagaatgagagggtgtattgc a" /listShort="yloA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 1550213..1550218 /Source="Nicolas_upshift_promotors" /id="U1293" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=989 /SigmaFactorBS="tacaccctctcattcttcctgcattcgataattatAGCATGa aatgggacgagtcaGAATAAGCATGCTTATAGAgtgatatctctataagagagcaggg g" /listShort="yloB, S571, yloC, ylzA, gmk, rpoZ" /listLong="coaBC" /label="promotor_-35" upshifts complement(1550213) /Source="Nicolas_upshifts" /id="U1292" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.766233766233766" /psig="0.999000999001" /xcortree=2006 /SigmaFactorBS="gctctcttatagagatatcactctataagcatgcttaTTCTG ActcgtcccatttCATGCTATAATTATCGAATGcaggaagaatgagagggtgtattgc a" /listShort="yloA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1550231..1550236) /Source="Nicolas_upshift_promotors" /id="U1292" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.766233766233766" /psig="0.999000999001" /xcortree=2006 /SigmaFactorBS="gctctcttatagagatatcactctataagcatgcttaTTCTG ActcgtcccatttCATGCTATAATTATCGAATGcaggaagaatgagagggtgtattgc a" /listShort="yloA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1550234..1550252 /Source="Nicolas_upshift_promotors" /id="U1293" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=989 /SigmaFactorBS="tacaccctctcattcttcctgcattcgataattatAGCATGa aatgggacgagtcaGAATAAGCATGCTTATAGAgtgatatctctataagagagcaggg g" /listShort="yloB, S571, yloC, ylzA, gmk, rpoZ" /listLong="coaBC" /label="promotor_-10" upshifts 1550238 /Source="Nicolas_upshifts" /id="U1293" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=989 /SigmaFactorBS="tacaccctctcattcttcctgcattcgataattatAGCATGa aatgggacgagtcaGAATAAGCATGCTTATAGAgtgatatctctataagagagcaggg g" /listShort="yloB, S571, yloC, ylzA, gmk, rpoZ" /listLong="coaBC" /label="upshifts" CDS 1550293..1552965 /gene="tcaB" /locus_tag="BSU_15650" /old_locus_tag="BSU15650" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12161109, 24415722" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12161109, 24415722; Product type t: transporter" /codon_start=1 /transl_table=11 /product="P-type calcium transport ATPase (sporulation)" /protein_id="NP_389448.1" /db_xref="EnsemblGenomes-Gn:BSU15650" /db_xref="EnsemblGenomes-Tr:CAB13439" /db_xref="GOA:O34431" /db_xref="InterPro:IPR001757" /db_xref="InterPro:IPR004014" /db_xref="InterPro:IPR005782" /db_xref="InterPro:IPR006068" /db_xref="InterPro:IPR008250" /db_xref="InterPro:IPR018303" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR023298" /db_xref="InterPro:IPR023299" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG13384" /db_xref="UniProtKB/Swiss-Prot:O34431" /translation="MKFHEMGQTDLLEATNTSMKQGLTEKEVKKRLDKHGPNELQEGK KTSALLLFFAQFKDFMVLVLLAATLISGFLGEYVDAVAIIAIVFVNGILGFFQERRAE QSLQALKELSTPHVMALREGSWTKIPSKELVPGDIVKFTSGDRIGADVRIVEARSLEI EESALTGESIPVVKHADKLKKPDVSLGDITNMAFMGTIVTRGSGVGVVVGTGMNTAMG KIADMLESAGTLSTPLQRRLEQLGKILIVVALLLTVLVVAVGVIQGHDLYSMFLAGVS LAVAAIPEGLPAIVTVALSLGVQRMIKQKSIVRKLPAVETLGCASIICSDKTGTMTQN KMTVTHVWSGGKTWRVAGAGYEPKGSFTLNEKEISVNEHKPLQQMLLFGALCNNSNIE KRDGEYVLDGDPTEGALLTAARKGGFSKEFVESNYRVIEEFPFDSARKMMTVIVENQD RKRYIITKGAPDVLMQRSSRIYYDGSAALFSNERKAETEAVLRHLASQALRTIAVAYR PIKAGETPSMEQAEKDLTMLGLSGIIDPPRPEVRQAIKECREAGIKTVMITGDHVETA KAIAKDLRLLPKSGKIMDGKMLNELSQEELSHVVEDVYVFARVSPEHKLKIVKAYQEN GHIVAMTGDGVNDAPAIKQADIGVSMGITGTDVAKEASSLVLVDDNFATIKSAIKEGR NIYENIRKFIRYLLASNVGEILVMLFAMLLALPLPLVPIQILWVNLVTDGLPAMALGM DQPEGDVMKRKPRHPKEGVFARKLGWKVVSRGFLIGVATILAFIIVYHRNPENLAYAQ TIAFATLVLAQLIHVFDCRSETSVFSRNPFQNLYLIGAVLSSILLMLVVIYYPPLQPI FHTVAITPGDWMLVIGMSAIPTFLLAGSLLTRKK*" /label="tcaB CDS" gene 1550293..1552965 /gene="tcaB" /locus_tag="BSU_15650" /old_locus_tag="BSU15650" /label="tcaB gene" promotor_-10 complement(1551698..1551717) /Source="Nicolas_upshift_promotors" /id="U1294" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.914085914085914" /psig="0.98001998001998" /xcortree=1702 /SigmaFactorBS="ttaataccgcctctgtttctgcttttctttCATTTGAAaaaa gagccgctgaGCCATCATAATAAATACGGGaagatcgctgcatgagtacatccggcgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1551709) /Source="Nicolas_upshifts" /id="U1294" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.914085914085914" /psig="0.98001998001998" /xcortree=1702 /SigmaFactorBS="ttaataccgcctctgtttctgcttttctttCATTTGAAaaaa gagccgctgaGCCATCATAATAAATACGGGaagatcgctgcatgagtacatccggcgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1551732..1551739) /Source="Nicolas_upshift_promotors" /id="U1294" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.914085914085914" /psig="0.98001998001998" /xcortree=1702 /SigmaFactorBS="ttaataccgcctctgtttctgcttttctttCATTTGAAaaaa gagccgctgaGCCATCATAATAAATACGGGaagatcgctgcatgagtacatccggcgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 1552971..1552990 /Source="Nicolas_upshift_promotors" /id="U1295" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.925074925074925" /psig="0.994005994005994" /xcortree=2170 /SigmaFactorBS="cgccatccctacttttttgctggcggggtcacttttaacaag aaaaaaataaattcaTATGATATAATCTTAGGGGTaatagcgtgtctattgccctttt a" /listShort="S571, yloC, ylzA, gmk, rpoZ, coaBC, priA, defA, fmt, rsmB, yloN, prpC, prkC, cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1552974..1553047 /Source="Nicolas_S_feature" /locus_tag="new_1640646_1640719" /HighExp="LPhT, LBGstat, T3.0H, H2O2, T3.30H, Salt, B60, Lbexp, UNK1, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="0.994, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S571" upshifts 1552974 /Source="Nicolas_upshifts" /id="U1295" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.925074925074925" /psig="0.994005994005994" /xcortree=2170 /SigmaFactorBS="cgccatccctacttttttgctggcggggtcacttttaacaag aaaaaaataaattcaTATGATATAATCTTAGGGGTaatagcgtgtctattgccctttt a" /listShort="S571, yloC, ylzA, gmk, rpoZ, coaBC, priA, defA, fmt, rsmB, yloN, prpC, prkC, cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="upshifts" CDS 1553048..1553923 /gene="yloC" /locus_tag="BSU_15660" /old_locus_tag="BSU15660" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389449.1" /db_xref="EnsemblGenomes-Gn:BSU15660" /db_xref="EnsemblGenomes-Tr:CAB13440" /db_xref="InterPro:IPR005229" /db_xref="InterPro:IPR013527" /db_xref="InterPro:IPR013551" /db_xref="SubtiList:BG13385" /db_xref="UniProtKB/Swiss-Prot:O34441" /translation="MIRSMTGFGSASKTQDDLSVSVELKSVNYRFKEVNARLPRPLLY FEDKLKQTILQHIQRGRIELFVSVDSDMLVEKRLEIDWPLLDEFVAAARDMKKRYQLS AEPDVMDFFKLDHVVQVHEEQTQNDKLEALIIDAAEEAVKGLCEMREKEGLLLAKDCL MHIDQLEELVRETELLAADVVSRYRERLYARIKEWTEDVLDESRLVTECAIFADRSDI TEEITRLKSHFAQFRDILASGGAVGRKLDFLVQELNREANTIGSKANDHQITKLVVEM KSSIEKIKEQVQNIE*" /label="yloC CDS" gene 1553048..1553923 /gene="yloC" /locus_tag="BSU_15660" /old_locus_tag="BSU15660" /label="yloC gene" CDS 1554000..1554269 /gene="remA" /locus_tag="BSU_15670" /old_locus_tag="BSU15670" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:19363116, 23396918, 23646920" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19363116, 23396918, 23646920; Product type r: regulator" /codon_start=1 /transl_table=11 /product="essential sporulation DNA binding protein; regulator of biofilm formation" /protein_id="NP_570902.1" /db_xref="EnsemblGenomes-Gn:BSU15670" /db_xref="EnsemblGenomes-Tr:CAE01452" /db_xref="InterPro:IPR007169" /db_xref="SubtiList:BG14185" /db_xref="UniProtKB/Swiss-Prot:Q7WY72" /translation="MTIKLINIGFGNIISANRMISIVSPESAPIKRMIQDARDRGMLI DATYGRRTRAVVVMDSDHIILSAVQPETVAHRLSVKEEIMDEGQG*" /label="remA CDS" gene 1554000..1554269 /gene="remA" /locus_tag="BSU_15670" /old_locus_tag="BSU15670" /label="remA gene" misc_feature complement(1554080..1554084) /Source="Nicolas_upshift_promotors" /id="U1296" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.889110889110889" /psig="0.001998001998002" /xcortree=58 /SigmaFactorBS="ccgtatgtagcgtcaattagcattccgcggtctcttgcatcc tgaatcatccgtttgattgGCGCAgactccgggctgacaatcgaaatcatccgattgg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1554085) /Source="Nicolas_upshifts" /id="U1296" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.889110889110889" /psig="0.001998001998002" /xcortree=58 /SigmaFactorBS="ccgtatgtagcgtcaattagcattccgcggtctcttgcatcc tgaatcatccgtttgattgGCGCAgactccgggctgacaatcgaaatcatccgattgg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1554277..1554891 /gene="gmk" /locus_tag="BSU_15680" /old_locus_tag="BSU15680" /EC_number="2.7.4.8" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 17012781, 24722991" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17012781, 24722991; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="guanylate kinase" /protein_id="NP_389450.2" /db_xref="EnsemblGenomes-Gn:BSU15680" /db_xref="EnsemblGenomes-Tr:CAB13441" /db_xref="GOA:O34328" /db_xref="InterPro:IPR008144" /db_xref="InterPro:IPR008145" /db_xref="InterPro:IPR017665" /db_xref="InterPro:IPR020590" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13386" /db_xref="UniProtKB/Swiss-Prot:O34328" /translation="MKERGLLIVLSGPSGVGKGTVRQAIFSQEDTKFEYSISVTTRSP REGEVNGVDYFFKTRDEFEQMIADNKLLEWAEYVGNYYGTPVDYVEQTLQDGKDVFLE IEVQGALQVRNAFPEGLFIFLAPPSLSELKNRIVTRGTETDALIENRMKAAKAEIEMM DAYDYVVENDNVETACDKIKAIVLAEHLKRERVAPRYKKMLEVE*" /label="gmk CDS" gene 1554277..1554891 /gene="gmk" /locus_tag="BSU_15680" /old_locus_tag="BSU15680" /label="gmk gene" CDS 1554895..1555098 /gene="rpoZ" /locus_tag="BSU_15690" /old_locus_tag="BSU15690" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12089032, 16159791, 17233676, 24476911, 25878038; Product type f: factor" /codon_start=1 /transl_table=11 /product="omega subunit of RNA polymerase" /protein_id="NP_389451.1" /db_xref="EnsemblGenomes-Gn:BSU15690" /db_xref="EnsemblGenomes-Tr:CAB13442" /db_xref="GOA:O35011" /db_xref="InterPro:IPR003716" /db_xref="InterPro:IPR006110" /db_xref="InterPro:IPR012293" /db_xref="InterPro:IPR036161" /db_xref="SubtiList:BG13387" /db_xref="UniProtKB/Swiss-Prot:O35011" /translation="MLDPSIDSLMNKLDSKYTLVTVSARRAREMQIKKDQMIEHTISH KYVGKALEEIDAGLLSFEKEDRE*" /label="rpoZ CDS" gene 1554895..1555098 /gene="rpoZ" /locus_tag="BSU_15690" /old_locus_tag="BSU15690" /label="rpoZ gene" downshifts 1555087 /Source="Nicolas_upshifts" /id="D877" /incds=0 /nref=118 /ntot=257 /MaxReadThrough="5.65143" /MaxDrop="4.7291" /score="-8.13961715" /energy="-7.7" /TU="U1293,U1295" /idTUdmin="U1293" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" CDS 1555179..1556399 /gene="coaBC" /locus_tag="BSU_15700" /old_locus_tag="BSU15700" /EC_number="4.1.1.36" /EC_number="6.3.2.5" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11278255, 11358972, 12140293, 14686929, 15530362; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="coenzyme A biosynthesis bifunctional protein CoaBC; phosphopantothenoylcysteine synthetase/decarboxylase" /protein_id="NP_389452.1" /db_xref="EnsemblGenomes-Gn:BSU15700" /db_xref="EnsemblGenomes-Tr:CAB13443" /db_xref="GOA:O35033" /db_xref="InterPro:IPR003382" /db_xref="InterPro:IPR005252" /db_xref="InterPro:IPR007085" /db_xref="InterPro:IPR035929" /db_xref="InterPro:IPR036551" /db_xref="SubtiList:BG13388" /db_xref="UniProtKB/Swiss-Prot:O35033" /translation="MLNNRNVLLCVSGGIAVYKACALTSKLVQAGANVKVIMTESACR FVSPLTFQALSRHEVYTDTFKEQNPSVISHIDAADWADLIIVAPATANVIGKLANGIA DDMLTTTLLAATAPVWIAPAMNVHMYDHPAVKRNISVLYQDGYCFIEPSEGYLACGYV GKGRLEEPENIVKLAEKHFAEETSAPLEGKHVVITAGPTREAIDPVRFFTNKSTGKMG YALAEAAVQLGARVILISGPVSLDQPKGLAEFIPVQSAADMREAVLSVYDASDIVIKT AAVADFTPKTVFDHKMKKQDGGMTLELKRTVDILKELGEKKKEQILVGFAAETQDIEH YARKKLAAKNLDLIVANDVKANGAGFGADTNIVTIFFKDGHKRELPIMSKLDVSFEIL QEIAALSKQTGERS*" /label="coaBC CDS" gene 1555179..1556399 /gene="coaBC" /locus_tag="BSU_15700" /old_locus_tag="BSU15700" /label="coaBC gene" S_feature complement(1556238..1556813) /Source="Nicolas_S_feature" /locus_tag="new_1643910_1644485_c" /HighExp="Etha, Salt, Sw, Gly, C30, M9-stat, B60, LPhT, HiTm, Heat" /AntisenseName="priA" /AntisenseCor="-5.1213364637925501E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S572" CDS 1556396..1558813 /gene="priA" /locus_tag="BSU_15710" /old_locus_tag="BSU15710" /function="16.9: Replicate" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10572298, 11917020, 12682299, 21170359, 22720735, 28527403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10572298, 11917020, 12682299, 21170359, 22720735, 28527403; Product type f : factor" /codon_start=1 /transl_table=11 /product="primosomal replication factor Y (primosomal protein N')" /protein_id="NP_389453.1" /db_xref="EnsemblGenomes-Gn:BSU15710" /db_xref="EnsemblGenomes-Tr:CAB13444" /db_xref="GOA:P94461" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR005259" /db_xref="InterPro:IPR006935" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11963" /db_xref="UniProtKB/Swiss-Prot:P94461" /translation="MNFAEVIVDVSTKNIDRPFDYKIPDHLKGMIKTGMRVIVPFGPR KIQGFVTAVKEASDLSGKSVKEVEDLLDLTPVLTEELMILSSWLSDKTLSFKITALQA MLPAALKAKYEKELKIAHGADLPPQVERLFSETKTLLYSDIPDHETLKLIQRHVQKGD IDVTYKVAQKTNKKMVRHIQANASKEELAKQAEGLSRQAAKQQAILHFLISEPEGVKI PAAELCKKTDTSSATIKTLIQKGLLKESYEEVYRDPYQDKMFKKTEPLPLTDEQRAAF EPIRETLDSDEHKVFLLHGVTGSGKTEIYLQSIEKVLAKGKEAIVLVPEISLTPQMVN RFKGRFGSQVAVMHSGLSTGEKYDEWRKIHRKEVRLVVGARSAIFAPFENLGMIIIDE EHESSYKQEEMPRYHAKEVAIKRAEHHSCPVVLGSATPTLESYARAQKGVYELLSLKH RVNHRVMPEVSLVDMREELRNGNRSMFSVELMEKLEETIAKGEQAVLFLNKRGYSSFV MCRDCGYVPQCPHCDISMTYHRYGQRLKCHYCGHEEPVPHTCPECASEHIRFFGTGTQ RVEEELTKVLPSARVIRMDVDTTSRKGAHEKLLSAFGEGKADILLGTQMIAKGLDFPN VTLVGVLSADTTLHIPDFRSAEKTFQLLTQVSGRAGRHEKPGHVIIQTYTPSHYSIQL TKTHDYETFYQHEMAHRREQSYPPYYYLALVTVSHEEVAKAAVTAEKIAHFLKANCGA DTKILGPSASPIARIKDRYRYQCVIKYKQETQLSALLKKILEHYKREIEQKHVMISID MNPYMMM*" /label="priA CDS" gene 1556396..1558813 /gene="priA" /locus_tag="BSU_15710" /old_locus_tag="BSU15710" /label="priA gene" promotor_-10 complement(1556809..1556827) /Source="Nicolas_upshift_promotors" /id="U1297" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=253 /SigmaFactorBS="cccctttttgaacatgcctttgaatcAGTTTCAgcgtctcat gatcGGGTATATCTGAATACAGCagcgtctttgtttcagaaaacagccgttccacttg c" /listShort="S572" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1556813) /Source="Nicolas_upshifts" /id="U1297" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=253 /SigmaFactorBS="cccctttttgaacatgcctttgaatcAGTTTCAgcgtctcat gatcGGGTATATCTGAATACAGCagcgtctttgtttcagaaaacagccgttccacttg c" /listShort="S572" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1556841..1556847) /Source="Nicolas_upshift_promotors" /id="U1297" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=253 /SigmaFactorBS="cccctttttgaacatgcctttgaatcAGTTTCAgcgtctcat gatcGGGTATATCTGAATACAGCagcgtctttgtttcagaaaacagccgttccacttg c" /listShort="S572" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1558664..1558668 /Source="Nicolas_upshift_promotors" /id="U1298" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=2458 /SigmaFactorBS="caagcgcgtcgccgatagccaggatcaaaGATAGatatcgct atcaatgCGTGATAAAATACAAACAGGaaacccagttatccgctttattgaagaagat a" /listShort="defA, fmt, rsmB, yloN, prpC, prkC, cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1558684..1558703 /Source="Nicolas_upshift_promotors" /id="U1298" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=2458 /SigmaFactorBS="caagcgcgtcgccgatagccaggatcaaaGATAGatatcgct atcaatgCGTGATAAAATACAAACAGGaaacccagttatccgctttattgaagaagat a" /listShort="defA, fmt, rsmB, yloN, prpC, prkC, cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1558695 /Source="Nicolas_upshifts" /id="U1298" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=2458 /SigmaFactorBS="caagcgcgtcgccgatagccaggatcaaaGATAGatatcgct atcaatgCGTGATAAAATACAAACAGGaaacccagttatccgctttattgaagaagat a" /listShort="defA, fmt, rsmB, yloN, prpC, prkC, cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="upshifts" CDS 1558840..1559322 /gene="defA" /locus_tag="BSU_15720" /old_locus_tag="BSU15720" /EC_number="3.5.1.88" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11429456, 16014871, 16207374" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11429456, 16014871, 16207374; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptide deformylase" /protein_id="NP_389454.1" /db_xref="EnsemblGenomes-Gn:BSU15720" /db_xref="EnsemblGenomes-Tr:CAB13445" /db_xref="GOA:P94462" /db_xref="InterPro:IPR023635" /db_xref="InterPro:IPR036821" /db_xref="SubtiList:BG11933" /db_xref="UniProtKB/Swiss-Prot:P94462" /translation="MAVKKVVTHPAEVLETPAETVTVFDKKLKKLLDDMYDTMLEMDG VGLAAPQIGILKRAAVVEIGDDRGRIDLVNPEILEKSGEQTGIEGCLSFPNVYGDVTR ADYVKVRAFNRQGKPFILEARGFLARAVQHEMDHLDGVLFTSKISKYYTEDELADMEG *" /label="defA CDS" gene 1558840..1559322 /gene="defA" /locus_tag="BSU_15720" /old_locus_tag="BSU15720" /label="defA gene" CDS 1559327..1560280 /gene="fmt" /locus_tag="BSU_15730" /old_locus_tag="BSU15730" /EC_number="2.1.2.9" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:769821, 769822, 98518, 9843487, 10858337, 26888283, 27983482" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 769821, 769822, 98518, 9843487, 10858337, 26888283, 27983482; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="methionyl-tRNA formyltransferase" /protein_id="NP_389455.1" /db_xref="EnsemblGenomes-Gn:BSU15730" /db_xref="EnsemblGenomes-Tr:CAB13446" /db_xref="GOA:P94463" /db_xref="InterPro:IPR001555" /db_xref="InterPro:IPR002376" /db_xref="InterPro:IPR005793" /db_xref="InterPro:IPR005794" /db_xref="InterPro:IPR011034" /db_xref="InterPro:IPR036477" /db_xref="InterPro:IPR037022" /db_xref="SubtiList:BG11937" /db_xref="UniProtKB/Swiss-Prot:P94463" /translation="MTRIVFMGTPDFSVPVLRTLIEDGYEVVGVVTQPDRPKGRKKVL TPPPVKEEALRHGIPVLQPEKVRLTEEIEKVLALKPDLIVTAAFGQILPKELLDSPKY GCINVHASLLPELRGGAPIHYSILQGKKKTGITIMYMVEKLDAGDMISKVEVDIEETD NVGTLHDKLSVAGAKLLSETVPNVIAGSISPEKQDEEKATYAPNIKREQELLDWSRTG EELYNQIRGLNPWPVAYTTLNGQNLKIWASKKIAAPTTAEPGTVVAVEKEGIIVATGN ETALLLTELQPAGKKRMKGEDFVRGAHVEAGDVLGVNNEKN*" /label="fmt CDS" gene 1559327..1560280 /gene="fmt" /locus_tag="BSU_15730" /old_locus_tag="BSU15730" /label="fmt gene" CDS 1560267..1561610 /gene="rsmB" /locus_tag="BSU_15740" /old_locus_tag="BSU15740" /EC_number="2.1.1.176" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14656444, 23729652, 27698115; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="RNA-binding Sun protein; 16S rRNA m5C967 methyltransferase, S-adenosyl-L-methionine-dependent" /protein_id="NP_389456.1" /db_xref="EnsemblGenomes-Gn:BSU15740" /db_xref="EnsemblGenomes-Tr:CAB13447" /db_xref="GOA:P94464" /db_xref="InterPro:IPR001678" /db_xref="InterPro:IPR004573" /db_xref="InterPro:IPR006027" /db_xref="InterPro:IPR018314" /db_xref="InterPro:IPR023267" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR035926" /db_xref="SubtiList:BG12253" /db_xref="UniProtKB/Swiss-Prot:P94464" /translation="MKKTSVRDIALEALIKLEQNQAYSNLLLKSVIKSNELSDQNRGL LTELVYGTLQNKIALDYMLKPFINKPQKVKPWVIQLLRLSLYQMEYLEKIPDRAAIHE AVEIAKIRGHKGIASFVNGVLRSIQREGVPSFDAIEDPVRRLATETSHPEWLVKEWAD AYGFEAAEKICRIHLIPPKQTLRVNQMKADRAELLDQMAAEGIEVEKGDLAEDAVKLL KGTIAGTHFFQNGEVSIQDESSMLVARALDPKSDETVLDACAAPGGKSAHIAELMKNK GSVTSLDLHKHKVKLIKEAADRLGLTIIHAETMDARKAGETFENEQFDRILVDAPCSG FGVIRRKPDMKYTKKPDDSARLAEIQLSILREIAPLVKKGGTLVYSTCTMDRTENDEV IHAFIQEHPDFEPDLSLEKRLPEKVRPFVRDGRLQILPHYFGTDGFFICSMRKKG*" /label="rsmB CDS" gene 1560267..1561610 /gene="rsmB" /locus_tag="BSU_15740" /old_locus_tag="BSU15740" /label="rsmB gene" CDS 1561614..1562705 /gene="rlmN" /locus_tag="BSU_15750" /old_locus_tag="BSU15750" /EC_number="2.1.1.192" /function="10.3: tRNA and rRNA base modification" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8973346, 18307109, 20184321, 21368151, 22891362, 27081063, 27902775; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="23S rRNA m2A2503 methyltransferase and tRNA A37 C2 methyltransferase" /protein_id="NP_389457.1" /db_xref="EnsemblGenomes-Gn:BSU15750" /db_xref="EnsemblGenomes-Tr:CAB13448" /db_xref="GOA:O34617" /db_xref="InterPro:IPR004383" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR027492" /db_xref="SubtiList:BG13389" /db_xref="UniProtKB/Swiss-Prot:O34617" /translation="MAELNKTKVRKELRTERPSIYSFELDEIKQWLTDNGEKPFRAAQ IFEWLYEKRVSSFEDMTNLSKDLREKLNTRFVLTTLKTAVKQTSQDGTMKFLFELHDG YTIETVLMRHEYGNSVCVTTQVGCRIGCTFCASTLGGLKRNLEAGEIVAQVVKVQKAL DETDERVSSVVIMGIGEPFDNFNEMLAFLKIINHDKGLNIGARHITVSTSGIIPKIYE FADQQMQINFAISLHAPNTEIRSRLMPINRAYKLPDLMEAVKYYINKTGRRISFEYGL FGGVNDQVEHAEELADLLEGVKCHVNLIPVNYVPERDYVRTPRDQIFAFEKTLKSRGV NVTIRREQGHDIDAACGQLRAKERQDETR*" /label="rlmN CDS" gene 1561614..1562705 /gene="rlmN" /locus_tag="BSU_15750" /old_locus_tag="BSU15750" /label="rlmN gene" CDS 1562712..1563476 /gene="prpC" /locus_tag="BSU_15760" /old_locus_tag="BSU15760" /EC_number="3.1.3.16" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10986276, 12399479, 17693724, 22720735, 24390483, 25012659" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986276, 12399479, 17693724, 22720735, 24390483, 25012659; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="multitarget phosphorylated protein phosphatase" /protein_id="NP_389458.1" /db_xref="EnsemblGenomes-Gn:BSU15760" /db_xref="EnsemblGenomes-Tr:CAB13449" /db_xref="GOA:O34779" /db_xref="InterPro:IPR001932" /db_xref="InterPro:IPR015655" /db_xref="InterPro:IPR036457" /db_xref="SubtiList:BG13390" /db_xref="UniProtKB/Swiss-Prot:O34779" /translation="MLTALKTDTGKIRQHNEDDAGIFKGKDEFILAVVADGMGGHLAG DVASKMAVKAMGEKWNEAETIPTAPSECEKWLIEQILSVNSKIYDHAQAHEECQGMGT TIVCALFTGKTVSVAHIGDSRCYLLQDDDFVQVTEDHSLVNELVRTGEISREDAEHHP RKNVLTKALGTDQLVSIDTRSFDIEPGDKLLLCSDGLTNKVEGTELKDILQSDSAPQE KVNLLVDKANQNGGEDNITAVLLELALQVEEGEDQC*" /label="prpC CDS" gene 1562712..1563476 /gene="prpC" /locus_tag="BSU_15760" /old_locus_tag="BSU15760" /label="prpC gene" downshifts 1562765 /Source="Nicolas_upshifts" /id="D878" /incds=0 /nref=5 /ntot=126 /MaxReadThrough="6.12318" /MaxDrop="3.8594" /score="-7.80200272" /energy="-10" /TU="U1295,U1298" /idTUdmin="U1300" /TUdmin="-4708" /isTUend="FALSE" /label="downshifts" CDS 1563470..1565416 /gene="prkC" /locus_tag="BSU_15770" /old_locus_tag="BSU15770" /EC_number="2.7.11.1" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:10986276, 12399479, 18984160, 24390483, 25845974, 26102633" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986276, 12399479, 18984160, 24390483, 25845974, 26102633; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="protein serine/threonine kinase" /protein_id="NP_389459.1" /db_xref="EnsemblGenomes-Gn:BSU15770" /db_xref="EnsemblGenomes-Tr:CAB13450" /db_xref="GOA:O34507" /db_xref="InterPro:IPR000719" /db_xref="InterPro:IPR005543" /db_xref="InterPro:IPR008271" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR017441" /db_xref="SubtiList:BG13391" /db_xref="UniProtKB/Swiss-Prot:O34507" /translation="MLIGKRISGRYQILRVIGGGGMANVYLAEDIILDREVAIKILRF DYANDNEFIRRFRREAQSASSLDHPNIVSIYDLGEEDDIYYIVMEYVEGMTLKEYITA NGPLHPKEALNIMEQIVSAIAHAHQNQIVHRDIKPHNILIDHMGNIKVTDFGIATALS STTITHTNSVLGSVHYLSPEQARGGLATKKSDIYALGIVLFELLTGRIPFDGESAVSI ALKHLQAETPSAKRWNPSVPQSVENIILKATAKDPFHRYETAEDMEADIKTAFDADRL NEKRFTIQEDEEMTKAIPIIKDEELAKAAGEKEAEVTTAQENKTKKNGKRKKWPWVLL TICLVFITAGILAVTVFPSLFMPKDVKIPDVSGMEYEKAAGLLEKEGLQVDSEVLEIS DEKIEEGLMVKTDPKADTTVKEGATVTLYKSTGKAKTEIGDVTGQTVDQAKKALKDQG FNHVTVNEVNDEKNAGTVIDQNPSAGTELVPSEDQVKLTVSIGPEDITLRDLKTYSKE AASGYLEDNGLKLVEKEAYSDDVPEGQVVKQKPAAGTAVKPGNEVEVTFSLGPEKKPA KTVKEKVKIPYEPENEGDELQVQIAVDDADHSISDTYEEFKIKEPTERTIELKIEPGQ KGYYQVMVNNKVVSYKTIEYPKDE*" /label="prkC CDS" gene 1563470..1565416 /gene="prkC" /locus_tag="BSU_15770" /old_locus_tag="BSU15770" /label="prkC gene" promotor_-35 1565325..1565331 /Source="Nicolas_upshift_promotors" /id="U1299" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=173 /SigmaFactorBS="cgactgaacgaacgatcgaactaaAGATTGAaccaggccaaa aaGGGTACTATCAAGTAATGGtaaacaataaagttgtcagctacaaaaccattgagta t" /listShort="cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1565345..1565363 /Source="Nicolas_upshift_promotors" /id="U1299" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=173 /SigmaFactorBS="cgactgaacgaacgatcgaactaaAGATTGAaccaggccaaa aaGGGTACTATCAAGTAATGGtaaacaataaagttgtcagctacaaaaccattgagta t" /listShort="cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1565361 /Source="Nicolas_upshifts" /id="U1299" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=173 /SigmaFactorBS="cgactgaacgaacgatcgaactaaAGATTGAaccaggccaaa aaGGGTACTATCAAGTAATGGtaaacaataaagttgtcagctacaaaaccattgagta t" /listShort="cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="upshifts" CDS 1565431..1566327 /gene="rsgA" /locus_tag="BSU_15780" /old_locus_tag="BSU15780" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15223319, 15828870, 16014871, 16485133, 17005971, 18007041, 18344364, 19246764, 22544754, 22720735, 28482099" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15223319, 15828870, 16014871, 16485133, 17005971, 18007041, 18344364, 19246764, 22544754, 22720735, 28482099; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="GTPase involved in ribosome biogenesis" /protein_id="NP_389460.1" /db_xref="EnsemblGenomes-Gn:BSU15780" /db_xref="EnsemblGenomes-Tr:CAB13451" /db_xref="GOA:O34530" /db_xref="InterPro:IPR004881" /db_xref="InterPro:IPR010914" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030378" /db_xref="InterPro:IPR031944" /db_xref="PDB:1T9H" /db_xref="SubtiList:BG13392" /db_xref="UniProtKB/Swiss-Prot:O34530" /translation="MPEGKIIKALSGFYYVLDESEDSDKVIQCRGRGIFRKNKITPLV GDYVVYQAENDKEGYLMEIKERTNELIRPPICNVDQAVLVFSAVQPSFSTALLDRFLV LVEANDIQPIICITKMDLIEDQDTEDTIQAYAEDYRNIGYDVYLTSSKDQDSLADIIP HFQDKTTVFAGQSGVGKSSLLNAISPELGLRTNEISEHLGRGKHTTRHVELIHTSGGL VADTPGFSSLEFTDIEEEELGYTFPDIREKSSSCKFRGCLHLKEPKCAVKQAVEDGEL KQYRYDHYVEFMTEIKDRKPRY*" /label="rsgA CDS" gene 1565431..1566327 /gene="rsgA" /locus_tag="BSU_15780" /old_locus_tag="BSU15780" /label="rsgA gene" CDS 1566332..1566985 /gene="rpe" /locus_tag="BSU_15790" /old_locus_tag="BSU15790" /EC_number="5.1.3.1" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 973353, 15755726, 16489742, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribulose-5-phosphate 3-epimerase" /protein_id="NP_389461.1" /db_xref="EnsemblGenomes-Gn:BSU15790" /db_xref="EnsemblGenomes-Tr:CAB13452" /db_xref="GOA:O34557" /db_xref="InterPro:IPR000056" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR026019" /db_xref="SubtiList:BG13393" /db_xref="UniProtKB/Swiss-Prot:O34557" /translation="MIKVAPSILSADFAALGNEIKDVEKGGADCIHIDVMDGHFVPNI TIGPLIVEAVRPVTDLPLDVHLMIEEPDRYIPAFAKAGADILSVHAEACPHLHRTIQL IKEQGVKAGVVLNPHTPVQVIEHVFDDLDLVLLMTVNPGFGGQKFIHSVLPKIKEVKR MADEKGKKDLLIEVDGGVNKETAPLVIEAGANLLVAGSAVYGQSDRKKAISEIRGSK* " /label="rpe CDS" gene 1566332..1566985 /gene="rpe" /locus_tag="BSU_15790" /old_locus_tag="BSU15790" /label="rpe gene" promotor_-35 1566983..1566992 /Source="Nicolas_upshift_promotors" /id="U1300" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.95104895104895" /psig="0.95104895104895" /xcortree=753 /SigmaFactorBS="aaaaagcaatttctgaaatcagaggaagtaaaTAAGCAGCTT tagaaaagagctgGGCATACAATAGCCTAAGCTctttttcctgtatgcagagaaagga a" /listShort="thiN" /listLong="S573, spoVM, S574, yloU, yloV" /label="promotor_-35" promotor_-10 1567006..1567025 /Source="Nicolas_upshift_promotors" /id="U1300" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.95104895104895" /psig="0.95104895104895" /xcortree=753 /SigmaFactorBS="aaaaagcaatttctgaaatcagaggaagtaaaTAAGCAGCTT tagaaaagagctgGGCATACAATAGCCTAAGCTctttttcctgtatgcagagaaagga a" /listShort="thiN" /listLong="S573, spoVM, S574, yloU, yloV" /label="promotor_-10" upshifts 1567011 /Source="Nicolas_upshifts" /id="U1300" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.95104895104895" /psig="0.95104895104895" /xcortree=753 /SigmaFactorBS="aaaaagcaatttctgaaatcagaggaagtaaaTAAGCAGCTT tagaaaagagctgGGCATACAATAGCCTAAGCTctttttcctgtatgcagagaaagga a" /listShort="thiN" /listLong="S573, spoVM, S574, yloU, yloV" /label="upshifts" CDS 1567058..1567702 /gene="thiN" /locus_tag="BSU_15800" /old_locus_tag="BSU15800" /EC_number="2.7.6.2" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14567704, 15150256, 16291685, 19490098; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thiamine pyrophosphokinase" /protein_id="NP_389462.1" /db_xref="EnsemblGenomes-Gn:BSU15800" /db_xref="EnsemblGenomes-Tr:CAB13453" /db_xref="GOA:O34664" /db_xref="InterPro:IPR006282" /db_xref="InterPro:IPR007371" /db_xref="InterPro:IPR007373" /db_xref="InterPro:IPR036371" /db_xref="InterPro:IPR036759" /db_xref="PDB:3LM8" /db_xref="SubtiList:BG13394" /db_xref="UniProtKB/Swiss-Prot:O34664" /translation="MKTINIVAGGPKNLIPDLTGYTDEHTLWIGVDKGTVTLLDAGII PVEAFGDFDSITEQERRRIEKAAPALHVYQAEKDQTDLDLALDWALEKQPDIIQIFGI TGGRADHFLGNIQLLYKGVKTNIKIRLIDKQNHIQMFPPGEYDIEKDENKRYISFIPF SEDIHELTLTGFKYPLNNCHITLGSTLCISNELIHSRGTFSFAKGILIMIRSTD*" /label="thiN CDS" gene 1567058..1567702 /gene="thiN" /locus_tag="BSU_15800" /old_locus_tag="BSU15800" /label="thiN gene" promotor_-35 1567463..1567469 /Source="Nicolas_upshift_promotors" /id="U1301" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.548451548451548" /psig="0.548451548451548" /xcortree=1059 /SigmaFactorBS="aaaaacgaacataaaaattaggctgatagacaaacaaaatca tATTCAAAtgttccctcctggtGAATATGATATTGAGAAGGatgaaaataagcgatat a" /listShort="S573, spoVM, S574" /listLong="yloU, yloV" /label="promotor_-35" upshifts 1567480 /Source="Nicolas_upshifts" /id="U1301" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.548451548451548" /psig="0.548451548451548" /xcortree=1059 /SigmaFactorBS="aaaaacgaacataaaaattaggctgatagacaaacaaaatca tATTCAAAtgttccctcctggtGAATATGATATTGAGAAGGatgaaaataagcgatat a" /listShort="S573, spoVM, S574" /listLong="yloU, yloV" /label="upshifts" promotor_-10 1567484..1567502 /Source="Nicolas_upshift_promotors" /id="U1301" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.548451548451548" /psig="0.548451548451548" /xcortree=1059 /SigmaFactorBS="aaaaacgaacataaaaattaggctgatagacaaacaaaatca tATTCAAAtgttccctcctggtGAATATGATATTGAGAAGGatgaaaataagcgatat a" /listShort="S573, spoVM, S574" /listLong="yloU, yloV" /label="promotor_-10" promotor_-35 1567593..1567598 /Source="Nicolas_upshift_promotors" /id="U1302" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1088 /SigmaFactorBS="cggttttaaatatcctctaaataattGTCATAttacgctcgg ttcaaCACTATGTATTAGTAACGAactcattcattcacgaggtactttttcgtttgca a" /listShort="S573, spoVM, S574, yloU, yloV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1567614..1567632 /Source="Nicolas_upshift_promotors" /id="U1302" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1088 /SigmaFactorBS="cggttttaaatatcctctaaataattGTCATAttacgctcgg ttcaaCACTATGTATTAGTAACGAactcattcattcacgaggtactttttcgtttgca a" /listShort="S573, spoVM, S574, yloU, yloV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1567627 /Source="Nicolas_upshifts" /id="U1302" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1088 /SigmaFactorBS="cggttttaaatatcctctaaataattGTCATAttacgctcgg ttcaaCACTATGTATTAGTAACGAactcattcattcacgaggtactttttcgtttgca a" /listShort="S573, spoVM, S574, yloU, yloV" /GFF_Attribute="listLong" /label="upshifts" S_feature 1567703..1567773 /Source="Nicolas_S_feature" /locus_tag="new_1655375_1655445" /HighExp="S4, S5, S7, S8, S6, S3, B36, G/S, B60, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigEF, SigB, SigA, SigA" /TUshortPSig="0.977, 0.548, 0.973, 1, 0.994" /TUlongSig="SigK" /TUlongPSig="0.951" /label="S573" CDS 1567774..1567854 /gene="spoVM" /locus_tag="BSU_15810" /old_locus_tag="BSU15810" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9922240, 10077851, 10913836, 12562810, 18820968, 25825747, 28408070" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9922240, 10077851, 10913836, 12562810, 18820968, 25825747, 28408070; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor required for normal spore cortex and coatsynthesis (stage V sporulation)" /protein_id="NP_389463.1" /db_xref="EnsemblGenomes-Gn:BSU15810" /db_xref="EnsemblGenomes-Tr:CAB13454" /db_xref="GOA:P37817" /db_xref="InterPro:IPR012609" /db_xref="PDB:2MVH" /db_xref="PDB:2MVJ" /db_xref="SubtiList:BG10776" /db_xref="UniProtKB/Swiss-Prot:P37817" /translation="MKFYTIKLPKFLGGIVRAMLGSFRKD*" /label="spoVM CDS" gene 1567774..1567854 /gene="spoVM" /locus_tag="BSU_15810" /old_locus_tag="BSU15810" /label="spoVM gene" downshifts 1567869 /Source="Nicolas_upshifts" /id="D879" /incds=0 /nref=178 /ntot=258 /MaxReadThrough="4.05442" /MaxDrop="7.745" /score="7.47691609" /energy="-16.9" /TU="U1301,U1302" /idTUdmin="U1295" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1567914..1568286 /Source="Nicolas_S_feature" /locus_tag="new_1655586_1655958" /HighExp="S4, S5, T5.0H, S3, S6, S8, S7, T4.0H, LoTm, T3.30H" /AntisenseName="rpmB" /AntisenseCor="-0.40376097579549802" /AntisenseRegPval="-11.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigEF" /TUshortPSig="0.977, 0.548" /TUlongSig="SigK" /TUlongPSig="0.951" /label="S574" CDS complement(1567927..1568115) /gene="rpmB" /locus_tag="BSU_15820" /old_locus_tag="BSU15820" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 8722036; Product type f : factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L28" /protein_id="NP_389464.1" /db_xref="EnsemblGenomes-Gn:BSU15820" /db_xref="EnsemblGenomes-Tr:CAB13455" /db_xref="GOA:P37807" /db_xref="InterPro:IPR001383" /db_xref="InterPro:IPR026569" /db_xref="InterPro:IPR034704" /db_xref="InterPro:IPR037147" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10777" /db_xref="UniProtKB/Swiss-Prot:P37807" /translation="MARKCVITGKKTTAGNNRSHAMNASKRTWGANLQKVRILVNGKP KKVYVSARALKSGKVERV*" /label="rpmB CDS" gene complement(1567927..1568115) /gene="rpmB" /locus_tag="BSU_15820" /old_locus_tag="BSU15820" /label="rpmB gene" downshifts complement(1567943) /Source="Nicolas_upshifts" /id="D880" /incds=0 /nref=216 /ntot=298 /MaxReadThrough="2.59598" /MaxDrop="7.48719" /score="15.2403969" /energy="-14.3" /TU="NA" /idTUdmin="U1303" /TUdmin="-20" /isTUend="TRUE" /label="downshifts" downshifts complement(1567989) /Source="Nicolas_upshifts" /id="D881" /incds=1 /nref=1 /ntot=18 /MaxReadThrough="7.6779" /MaxDrop="3.1786" /score="15.2403969" /energy="-14.3" /TU="U1303" /idTUdmin="U1303" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" S_feature complement(1568116..1568208) /Source="Nicolas_S_feature" /locus_tag="new_1655788_1655880_c" /HighExp="HPh, LPh, HiOs, LBGexp, aero, G180, GM 15, dia0, MG 25, MG t5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S575" promotor_-10 complement(1568190..1568209) /Source="Nicolas_upshift_promotors" /id="U1303" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.782217782217782" /psig=1 /xcortree=2637 /SigmaFactorBS="agatgtcaagtgaattttcttgaaagatgatgaaacaataGT TGcaaacgttttttagcTGTGGTAAATTATTTAAAGTatccatatcgaaagcatctaa g" /listShort="S575, rpmB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1568208) /Source="Nicolas_upshifts" /id="U1303" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.782217782217782" /psig=1 /xcortree=2637 /SigmaFactorBS="agatgtcaagtgaattttcttgaaagatgatgaaacaataGT TGcaaacgttttttagcTGTGGTAAATTATTTAAAGTatccatatcgaaagcatctaa g" /listShort="S575, rpmB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1568225..1568228) /Source="Nicolas_upshift_promotors" /id="U1303" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.782217782217782" /psig=1 /xcortree=2637 /SigmaFactorBS="agatgtcaagtgaattttcttgaaagatgatgaaacaataGT TGcaaacgttttttagcTGTGGTAAATTATTTAAAGTatccatatcgaaagcatctaa g" /listShort="S575, rpmB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1568259..1568266 /Source="Nicolas_upshift_promotors" /id="U1304" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.54045954045954" /psig="0.99100899100899" /xcortree=2309 /SigmaFactorBS="ctattgtttcatcatctttcaagaaaattcaCTTGACATctt gcggaaacagcAGCGCTATAGTATATGTAGaggtacggccagcgattattgcctggtc t" /listShort="yloU, yloV, S576, sdaAB, sdaAA, recG" /listLong="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /label="promotor_-35" promotor_-10 1568281..1568299 /Source="Nicolas_upshift_promotors" /id="U1304" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.54045954045954" /psig="0.99100899100899" /xcortree=2309 /SigmaFactorBS="ctattgtttcatcatctttcaagaaaattcaCTTGACATctt gcggaaacagcAGCGCTATAGTATATGTAGaggtacggccagcgattattgcctggtc t" /listShort="yloU, yloV, S576, sdaAB, sdaAA, recG" /listLong="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /label="promotor_-10" upshifts 1568288 /Source="Nicolas_upshifts" /id="U1304" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.54045954045954" /psig="0.99100899100899" /xcortree=2309 /SigmaFactorBS="ctattgtttcatcatctttcaagaaaattcaCTTGACATctt gcggaaacagcAGCGCTATAGTATATGTAGaggtacggccagcgattattgcctggtc t" /listShort="yloU, yloV, S576, sdaAB, sdaAA, recG" /listLong="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /label="upshifts" promotor_-35 1568327..1568330 /Source="Nicolas_upshift_promotors" /id="U1305" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.451548451548452" /psig="0.99100899100899" /xcortree=2326 /SigmaFactorBS="tatgtagaggtacggccagcgattattgcctggtCTTTtcat aatggaaaccATATAGTAGAATAGCTGTAActctatgcattcgaaggaggaactagtg t" /listShort="yloU, yloV, S576, sdaAB, sdaAA, recG" /listLong="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /label="promotor_-35" promotor_-10 1568345..1568364 /Source="Nicolas_upshift_promotors" /id="U1305" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.451548451548452" /psig="0.99100899100899" /xcortree=2326 /SigmaFactorBS="tatgtagaggtacggccagcgattattgcctggtCTTTtcat aatggaaaccATATAGTAGAATAGCTGTAActctatgcattcgaaggaggaactagtg t" /listShort="yloU, yloV, S576, sdaAB, sdaAA, recG" /listLong="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /label="promotor_-10" upshifts 1568353 /Source="Nicolas_upshifts" /id="U1305" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.451548451548452" /psig="0.99100899100899" /xcortree=2326 /SigmaFactorBS="tatgtagaggtacggccagcgattattgcctggtCTTTtcat aatggaaaccATATAGTAGAATAGCTGTAActctatgcattcgaaggaggaactagtg t" /listShort="yloU, yloV, S576, sdaAB, sdaAA, recG" /listLong="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /label="upshifts" CDS 1568392..1568754 /gene="yloU" /locus_tag="BSU_15830" /old_locus_tag="BSU15830" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16014871, 17114254, 24178028, 28579978; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative factor involved in malonyl-CoA synthesis" /protein_id="NP_389465.1" /db_xref="EnsemblGenomes-Gn:BSU15830" /db_xref="EnsemblGenomes-Tr:CAB13456" /db_xref="InterPro:IPR005531" /db_xref="InterPro:IPR036837" /db_xref="SubtiList:BG13395" /db_xref="UniProtKB/Swiss-Prot:O34318" /translation="MSIELRTKYGQIDISNEVIAMVAGGAAVDCYGIVGMASKNQIKD GLTEILRKENFSRGVQVRQEGEQIHIDMYIIVSYGTKISEVAHNVQTKVKYTVNQTIG LAVDSVNIYVQGVRVTNP*" /label="yloU CDS" gene 1568392..1568754 /gene="yloU" /locus_tag="BSU_15830" /old_locus_tag="BSU15830" /label="yloU gene" downshifts complement(1568605) /Source="Nicolas_upshifts" /id="D882" /incds=1 /nref=1 /ntot=143 /MaxReadThrough="1.75412" /MaxDrop="2.71497" /score="15.2403969" /energy="-14.3" /TU="NA" /idTUdmin="U1303" /TUdmin="-682" /isTUend="FALSE" /label="downshifts" CDS 1568770..1570431 /gene="yloV" /locus_tag="BSU_15840" /old_locus_tag="BSU15840" /EC_number="2.7.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16647083, 22333191, 22517742; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme structurally related to dihydroxyacetone/glyceraldehyde kinase" /protein_id="NP_389466.1" /db_xref="EnsemblGenomes-Gn:BSU15840" /db_xref="EnsemblGenomes-Tr:CAB13457" /db_xref="GOA:O34751" /db_xref="InterPro:IPR004007" /db_xref="InterPro:IPR019986" /db_xref="InterPro:IPR033470" /db_xref="InterPro:IPR036117" /db_xref="SubtiList:BG13396" /db_xref="UniProtKB/Swiss-Prot:O34751" /translation="MSIRTLDGRTFAEMILAGAQNLSQNASAVDALNVFPVPDGDTGT NMNLSMTSGAREVEQMDTDDIGKVGSALSKGLLMGARGNSGVILSQLFRGFSKNIETK KEINALEFAAALQAGVDMAYKAVMKPVEGTILTVAKDAAKKAMILAEKETDITALMTA VTEEAEASLNRTPELLPVLKEVGVVDSGGKGLLCVYEGFLASLKGETVPQKAVLPSLD DMVSAEHHKSAQSMMNTEDIEFGFCTEVMVRLDQTKREFDEGTFRQDLSQFGDSLLVI ADESLAKVHIHAEEPGNVLNYAQHYGELIKIKIENMREQHTSIISQESKPADNETPPA KQPYGIVTVAMGEGIADLFKSIGASVVIEGGQTMNPSTEDIVDAVKSVNADTVFILPN NSNIIMAANQAASVVDEQVFVIPAKTVPQGMSALLAFNPDQEAEANEANMLSAIQQVK SGQVTFSVRDTHIDGKDIKKGDFMGILNGTIIGTSENQLSAAKMLLSEMIGEDDEIVT ILYGEDASQEEAEQLEAFLSEKYEEIEVEIHNGKQPLYSYIVSAE*" /label="yloV CDS" gene 1568770..1570431 /gene="yloV" /locus_tag="BSU_15840" /old_locus_tag="BSU15840" /label="yloV gene" S_feature 1570432..1570521 /Source="Nicolas_S_feature" /locus_tag="new_1658104_1658193" /HighExp="G135, G180, G150, LBGexp, Oxctl, Paraq, dia0, LPh, Lbexp, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.37023200000000001" /TUshortSig="SigA, SigA" /TUshortPSig="0.991, 0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S576" promotor_-35 1570494..1570501 /Source="Nicolas_upshift_promotors" /id="U1306" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=385 /SigmaFactorBS="gcttttaagtgcggcagcgctgtaacgcgccCGCTTGCCatt ttatatctgaTCAATTAGTCTAGAAGCAAAgcgctaataagctctggttcataaggag g" /listShort="sdaAB, sdaAA, recG, fapR, plsX, fabD, fabG, acpA, S577, rnc" /listLong="smc, ftsY" /label="promotor_-35" promotor_-10 1570515..1570534 /Source="Nicolas_upshift_promotors" /id="U1306" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=385 /SigmaFactorBS="gcttttaagtgcggcagcgctgtaacgcgccCGCTTGCCatt ttatatctgaTCAATTAGTCTAGAAGCAAAgcgctaataagctctggttcataaggag g" /listShort="sdaAB, sdaAA, recG, fapR, plsX, fabD, fabG, acpA, S577, rnc" /listLong="smc, ftsY" /label="promotor_-10" upshifts 1570523 /Source="Nicolas_upshifts" /id="U1306" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=385 /SigmaFactorBS="gcttttaagtgcggcagcgctgtaacgcgccCGCTTGCCatt ttatatctgaTCAATTAGTCTAGAAGCAAAgcgctaataagctctggttcataaggag g" /listShort="sdaAB, sdaAA, recG, fapR, plsX, fabD, fabG, acpA, S577, rnc" /listLong="smc, ftsY" /label="upshifts" CDS 1570570..1571232 /gene="sdaAB" /locus_tag="BSU_15850" /old_locus_tag="BSU15850" /EC_number="4.3.1.17" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8385012, 9244285, 16014871, 22686449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8385012, 9244285, 16014871, 22686449; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-serine dehydratase (beta chain)" /protein_id="NP_389467.1" /db_xref="EnsemblGenomes-Gn:BSU15850" /db_xref="EnsemblGenomes-Tr:CAB13458" /db_xref="GOA:O34635" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR004643" /db_xref="InterPro:IPR005131" /db_xref="InterPro:IPR029009" /db_xref="SubtiList:BG13397" /db_xref="UniProtKB/Swiss-Prot:O34635" /translation="MKYRSVFDIIGPVMIGPSSSHTAGAARIGRVARSLFGREPERII VSFYGSFAETYKGHGTDVAIIGGLLDFDTFDERIKTAIQIAEAKGIDIEFRVEDAVPV HPNTAKITISDEKGELELTGISIGGGKIEITELNGFELRLSGNHPAILVVHNDKFGTI AGVANVLAKFSINVGHMEVARKDIGQLALMTIEVDQNIDDHILDELSKLPNIIQVTKI AD*" /label="sdaAB CDS" gene 1570570..1571232 /gene="sdaAB" /locus_tag="BSU_15850" /old_locus_tag="BSU15850" /label="sdaAB gene" CDS 1571258..1572160 /gene="sdaAA" /locus_tag="BSU_15860" /old_locus_tag="BSU15860" /EC_number="4.3.1.17" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2504697, 16014871, 22686449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2504697, 16014871, 22686449; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-serine dehydratase (alpha chain)" /protein_id="NP_389468.1" /db_xref="EnsemblGenomes-Gn:BSU15860" /db_xref="EnsemblGenomes-Tr:CAB13459" /db_xref="GOA:O34607" /db_xref="InterPro:IPR004642" /db_xref="InterPro:IPR005130" /db_xref="SubtiList:BG13398" /db_xref="UniProtKB/Swiss-Prot:O34607" /translation="MFRNVKELIEITKEKQILISDVMIAQEMEVTEKTKEDIFQQMDH NLSVMEAAVQKGLEGVTSQTGLTGGDAVKLQAYIRSGKSLSGPLILDAVSKAVATNEV NAAMGTICATPTAGSAGVVPGTLFAVKEKLNPTREQMIRFLFTAGAFGFVVANNASIS GAAGGCQAEVGSASGMAAAAIVEMAGGTPEQSAEAMAITLKNMLGLVCDPVAGLVEVP CVKRNAMGASNAMIAADMALAGITSRIPCDEVIDAMYKIGQTMPTALRETGQGGLAAT PTGRELEKKIFGGALGSRETTSAN*" /label="sdaAA CDS" gene 1571258..1572160 /gene="sdaAA" /locus_tag="BSU_15860" /old_locus_tag="BSU15860" /label="sdaAA gene" CDS 1572138..1574186 /gene="recG" /locus_tag="BSU_15870" /old_locus_tag="BSU15870" /EC_number="3.6.4.12" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:1905712, 1494351, 15317759, 15533834, 16014871, 28078722, 28155219, 28527403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1905712, 1494351, 15317759, 15533834, 16014871, 28078722, 28155219, 28527403; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branch migrating ATP-dependent DNA helicase involved in DNA recombination and repair" /protein_id="NP_389469.1" /db_xref="EnsemblGenomes-Gn:BSU15870" /db_xref="EnsemblGenomes-Tr:CAB13460" /db_xref="GOA:O34942" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR004609" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR033454" /db_xref="SubtiList:BG13399" /db_xref="UniProtKB/Swiss-Prot:O34942" /translation="MKQHQQTSIANIKGIGPETEKTLNELGIYDISDLLNYFPYRYDD YELRDLEEVKHDERVTVEGKVHSEPSLTYYGKKRNRLTFRLLVGHYLITAVCFNRPYL KKKLSLGSVVTVSGKWDKHRQTISVQELKNGPHQEDKSIEPVYSVKENVTVKMMRRFI QQALTQYADSLPDPLPEKLRKSYKLPDYYQALKAMHQPETREALKLARRRFVYEEFLL FQLKMQAFRKAEREQTQGIRQRFSNEELMRFIKSLPFPLTNAQSRVLREITADMSSPY RMNRLLQGDVGSGKTAVAAIALYAAILSGYQGALMVPTEILAEQHADSLVSLFEKWDV SVALLTSSVKGKRRKELLERLAAGEIDILVGTHALIQDEVEFKALSLVITDEQHRFGV EQRKKLRNKGQDPDVLFMTATPIPRTLAITVFGEMDVSVIDEMPAGRKRIETYWVKHD MLDRILAFVEKELKQGRQAYIICPLIEESDKLDVQNAIDVYNMLSDIFRGKWNVGLMH GKLHSDEKDQVMREFSANHCQILVSTTVVEVGVNVPNATIMVIYDADRFGLSQLHQLR GRVGRGEHQSFCILMADPKSETGKERMRIMSETNDGFELSEKDLELRGPGDFFGKKQS GMPEFKVADMVHDYRALETARQDAANLVASDAFWKEPEYAVLRDELLKSGVMDGEKLS *" /label="recG CDS" gene 1572138..1574186 /gene="recG" /locus_tag="BSU_15870" /old_locus_tag="BSU15870" /label="recG gene" promotor_-35 1574222..1574229 /Source="Nicolas_upshift_promotors" /id="U1307" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.522477522477522" /psig=1 /xcortree=2187 /SigmaFactorBS="tcagaagtttttggtgttcagccagaaacaatCGTTGCATtc caatctatgaaaTTATATACTACTATTAGTACctagtcttaattgtccggatggtgtt t" /listShort="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1574244..1574263 /Source="Nicolas_upshift_promotors" /id="U1307" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.522477522477522" /psig=1 /xcortree=2187 /SigmaFactorBS="tcagaagtttttggtgttcagccagaaacaatCGTTGCATtc caatctatgaaaTTATATACTACTATTAGTACctagtcttaattgtccggatggtgtt t" /listShort="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1574250 /Source="Nicolas_upshifts" /id="U1307" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.522477522477522" /psig=1 /xcortree=2187 /SigmaFactorBS="tcagaagtttttggtgttcagccagaaacaatCGTTGCATtc caatctatgaaaTTATATACTACTATTAGTACctagtcttaattgtccggatggtgtt t" /listShort="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="upshifts" CDS 1574295..1574861 /gene="fapR" /locus_tag="BSU_15880" /old_locus_tag="BSU15880" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12737802, 17962296, 20201588, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12737802, 17962296, 20201588, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcription factor controlling fatty acid and phospholipid metabolism (FapR-malonyl-Coa)" /protein_id="NP_389470.1" /db_xref="EnsemblGenomes-Gn:BSU15880" /db_xref="EnsemblGenomes-Tr:CAB13461" /db_xref="GOA:O34835" /db_xref="InterPro:IPR006683" /db_xref="InterPro:IPR017275" /db_xref="InterPro:IPR029069" /db_xref="InterPro:IPR036388" /db_xref="PDB:2F3X" /db_xref="PDB:2F41" /db_xref="SubtiList:BG13400" /db_xref="UniProtKB/Swiss-Prot:O34835" /translation="MRRNKRERQELLQQTIQATPFITDEELAGKFGVSIQTIRLDRLE LSIPELRERIKNVAEKTLEDEVKSLSLDEVIGEIIDLELDDQAISILEIKQEHVFSRN QIARGHHLFAQANSLAVAVIDDELALTASADIRFTRQVKQGERVVAKAKVTAVEKEKG RTVVEVNSYVGEEIVFSGRFDMYRSKHS*" /label="fapR CDS" gene 1574295..1574861 /gene="fapR" /locus_tag="BSU_15880" /old_locus_tag="BSU15880" /label="fapR gene" CDS 1574875..1575876 /gene="plsX" /locus_tag="BSU_15890" /old_locus_tag="BSU15890" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8759840, 12682299, 16949372, 17557823, 17645809, 18369234, 19282621, 19850612, 24224907, 26816052, 26850107" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8759840, 12682299, 16949372, 17557823, 17645809, 18369234, 19282621, 19850612, 24224907, 26816052, 26850107; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="phosphate:acyl-ACP acyltransferase" /protein_id="NP_389471.1" /db_xref="EnsemblGenomes-Gn:BSU15890" /db_xref="EnsemblGenomes-Tr:CAB13462" /db_xref="GOA:P71018" /db_xref="InterPro:IPR003664" /db_xref="InterPro:IPR012281" /db_xref="PDB:1VI1" /db_xref="SubtiList:BG11843" /db_xref="UniProtKB/Swiss-Prot:P71018" /translation="MRIAVDAMGGDHAPKAVIDGVIKGIEAFDDLHITLVGDKTTIES HLTTTSDRITVLHADEVIEPTDEPVRAVRRKKNSSMVLMAQEVAENRADACISAGNTG ALMTAGLFIVGRIKGIDRPALAPTLPTVSGDGFLLLDVGANVDAKPEHLVQYAIMGSV YSQQVRGVTSPRVGLLNVGTEDKKGNELTKQTFQILKETANINFIGNVEARDLLDDVA DVVVTDGFTGNVTLKTLEGSALSIFKMMRDVMTSTLTSKLAAAVLKPKLKEMKMKMEY SNYGGASLFGLKAPVIKAHGSSDSNAVFHAIRQAREMVSQNVAALIQEEVKEEKTDE* " /label="plsX CDS" gene 1574875..1575876 /gene="plsX" /locus_tag="BSU_15890" /old_locus_tag="BSU15890" /label="plsX gene" CDS 1575895..1576848 /gene="fabD" /locus_tag="BSU_15900" /old_locus_tag="BSU15900" /EC_number="2.3.1.39" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14586097, 19850612" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14586097, 19850612; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="malonyl CoA:acyl carrier protein transacylase" /protein_id="NP_389472.1" /db_xref="EnsemblGenomes-Gn:BSU15900" /db_xref="EnsemblGenomes-Tr:CAB13463" /db_xref="GOA:P71019" /db_xref="InterPro:IPR004410" /db_xref="InterPro:IPR014043" /db_xref="InterPro:IPR016035" /db_xref="InterPro:IPR016036" /db_xref="InterPro:IPR020801" /db_xref="InterPro:IPR024925" /db_xref="SubtiList:BG11836" /db_xref="UniProtKB/Swiss-Prot:P71019" /translation="MSKIAFLFPGQGSQFIGMGKELYEQVPAAKRLFDEADETLETKL SSLIFEGDAEELTLTYNAQPALLTTSIAVLEKFKESGITPDFTAGHSLGEYSALVAAG ALSFKDAVYTVRKRGEFMNEAVPAGEGAMAAILGMDAEALKQVTDKVTEEGNLVQLAN LNCPGQIVISGTAKGVELASELAKENGAKRAIPLEVSGPFHSELMKPAAEKLKEVLDA CDIKDADVPVISNVSADVMTEKADIKEKLIEQLYSPVRFEESINKLIAEGVTTFIEIG PGKVLSGLVKKVNRRLKTIAVSDPETIELAIQTLKEENDNA*" /label="fabD CDS" gene 1575895..1576848 /gene="fabD" /locus_tag="BSU_15900" /old_locus_tag="BSU15900" /label="fabD gene" CDS 1576841..1577581 /gene="fabG" /locus_tag="BSU_15910" /old_locus_tag="BSU15910" /EC_number="1.1.1.100" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8759840, 12655455, 12682299, 19850612, 28126742" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8759840, 12655455, 12682299, 19850612, 28126742; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="beta-ketoacyl-acyl carrier protein reductase" /protein_id="NP_389473.1" /db_xref="EnsemblGenomes-Gn:BSU15910" /db_xref="EnsemblGenomes-Tr:CAB13464" /db_xref="GOA:P51831" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR011284" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11535" /db_xref="UniProtKB/Swiss-Prot:P51831" /translation="MLNDKTAIVTGASRGIGRSIALDLAKSGANVVVNYSGNEAKANE VVDEIKSMGRKAIAVKADVSNPEDVQNMIKETLSVFSTIDILVNNAGITRDNLIMRMK EDEWDDVININLKGVFNCTKAVTRQMMKQRSGRIINVSSIVGVSGNPGQANYVAAKAG VIGLTKSSAKELASRNITVNAIAPGFISTDMTDKLAKDVQDEMLKQIPLARFGEPSDV SSVVTFLASEGARYMTGQTLHIDGGMVM*" /label="fabG CDS" gene 1576841..1577581 /gene="fabG" /locus_tag="BSU_15910" /old_locus_tag="BSU15910" /label="fabG gene" promotor_-35 1577612..1577616 /Source="Nicolas_upshift_promotors" /id="U1308" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=2635 /SigmaFactorBS="tgtaagttttttctcgaaaatttcatcgtagtttcTCTAGtt ttttaaaaacgaaTCCACTATAATACTTGAGGGgaggtgaattgctatggcagacaca t" /listShort="acpA, S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1577632..1577651 /Source="Nicolas_upshift_promotors" /id="U1308" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=2635 /SigmaFactorBS="tgtaagttttttctcgaaaatttcatcgtagtttcTCTAGtt ttttaaaaacgaaTCCACTATAATACTTGAGGGgaggtgaattgctatggcagacaca t" /listShort="acpA, S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1577637 /Source="Nicolas_upshifts" /id="U1308" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=2635 /SigmaFactorBS="tgtaagttttttctcgaaaatttcatcgtagtttcTCTAGtt ttttaaaaacgaaTCCACTATAATACTTGAGGGgaggtgaattgctatggcagacaca t" /listShort="acpA, S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="upshifts" CDS 1577665..1577898 /gene="acpA" /locus_tag="BSU_15920" /old_locus_tag="BSU15920" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8759840, 12682299, 19850612, 27467752" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8759840, 12682299, 19850612, 27467752; Product type c: carrier" /codon_start=1 /transl_table=11 /product="acyl carrier protein" /protein_id="NP_389474.1" /db_xref="EnsemblGenomes-Gn:BSU15920" /db_xref="EnsemblGenomes-Tr:CAB13465" /db_xref="GOA:P80643" /db_xref="InterPro:IPR003231" /db_xref="InterPro:IPR006162" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR036736" /db_xref="PDB:1F80" /db_xref="PDB:1HY8" /db_xref="PDB:2X2B" /db_xref="SubtiList:BG11536" /db_xref="UniProtKB/Swiss-Prot:P80643" /translation="MADTLERVTKIIVDRLGVDEADVKLEASFKEDLGADSLDVVELV MELEDEFDMEISDEDAEKIATVGDAVNYIQNQQ*" /label="acpA CDS" gene 1577665..1577898 /gene="acpA" /locus_tag="BSU_15920" /old_locus_tag="BSU15920" /label="acpA gene" downshifts 1577879 /Source="Nicolas_upshifts" /id="D883" /incds=0 /nref=22 /ntot=197 /MaxReadThrough="8.12206" /MaxDrop="4.1545" /score="-8.42930766" /energy="-17.4" /TU="U1306,U1307,U1308" /idTUdmin="U1306" /TUdmin="-880" /isTUend="FALSE" /label="downshifts" promotor_no_box 1577907..1578007 /Source="Nicolas_upshift_promotors" /id="U1309" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.502497502497502" /psig="0.030969030969031" /xcortree=1637 /SigmaFactorBS="taaaagtcccgccgaaacgcggggctttagccctttattcgt gcagttattacagcatgccgcttttacgcgcgctgtatccggtttagtcagagaagcg c" /listShort="S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="promotor_no_box" S_feature 1577967..1578037 /Source="Nicolas_S_feature" /locus_tag="new_1665639_1665709" /HighExp="LBGstat, dia5, Cold, LBGtran, C30, Diami, G135, LBGexp, G/S, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigA, SigA" /TUshortPSig="0.031, 1, 1, 0.999" /TUlongSig="SigA, SigA" /TUlongPSig="0.991, 0.991" /label="S577" upshifts 1577967 /Source="Nicolas_upshifts" /id="U1309" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.502497502497502" /psig="0.030969030969031" /xcortree=1637 /SigmaFactorBS="taaaagtcccgccgaaacgcggggctttagccctttattcgt gcagttattacagcatgccgcttttacgcgcgctgtatccggtttagtcagagaagcg c" /listShort="S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="upshifts" CDS 1578038..1578787 /gene="rnc" /locus_tag="BSU_15930" /old_locus_tag="BSU15930" /EC_number="3.1.26.3" /experiment="publication(s) with functional evidences, PMID:11123676, 12682299, 16179796, 22412379, 23300471, 26883633" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11123676, 12682299, 16179796, 22412379, 23300471, 26883633; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease III" /protein_id="NP_389475.1" /db_xref="EnsemblGenomes-Gn:BSU15930" /db_xref="EnsemblGenomes-Tr:CAB13466" /db_xref="GOA:P51833" /db_xref="InterPro:IPR000999" /db_xref="InterPro:IPR011907" /db_xref="InterPro:IPR014720" /db_xref="InterPro:IPR036389" /db_xref="SubtiList:BG11537" /db_xref="UniProtKB/Swiss-Prot:P51833" /translation="MSKHSHYKDKKKFYKKVEQFKEFQERISVHFQNEKLLYQAFTHS SYVNEHRKKPYEDNERLEFLGDAVLELTISRFLFAKYPAMSEGDLTKLRAAIVCEPSL VSLAHELSFGDLVLLGKGEEMTGGRKRPALLADVFEAFIGALYLDQGLEPVESFLKVY VFPKINDGAFSHVMDFKSQLQEYVQRDGKGSLEYKISNEKGPAHNREFEAIVSLKGEP LGVGNGRSKKEAEQHAAQEALAKLQKHHTKQ*" /label="rnc CDS" gene 1578038..1578787 /gene="rnc" /locus_tag="BSU_15930" /old_locus_tag="BSU15930" /label="rnc gene" downshifts 1578759 /Source="Nicolas_upshifts" /id="D884" /incds=0 /nref=78 /ntot=211 /MaxReadThrough="6.42554" /MaxDrop="5.70849" /score="-8.42930766" /energy="-17.4" /TU="U1307,U1308,U1309" /idTUdmin="U1306" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1578829..1578835 /Source="Nicolas_upshift_promotors" /id="U1310" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.816183816183816" /psig="0.985014985014985" /xcortree=110 /SigmaFactorBS="ggatttcagtatgtatgccgTCTTATTtgaccaatgttTATG ATAGAATTGAAATACTtattacataaggaggatcgctatgttcctcaaacgtttagac g" /listShort="smc, ftsY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1578847..1578866 /Source="Nicolas_upshift_promotors" /id="U1310" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.816183816183816" /psig="0.985014985014985" /xcortree=110 /SigmaFactorBS="ggatttcagtatgtatgccgTCTTATTtgaccaatgttTATG ATAGAATTGAAATACTtattacataaggaggatcgctatgttcctcaaacgtttagac g" /listShort="smc, ftsY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1578869 /Source="Nicolas_upshifts" /id="U1310" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.816183816183816" /psig="0.985014985014985" /xcortree=110 /SigmaFactorBS="ggatttcagtatgtatgccgTCTTATTtgaccaatgttTATG ATAGAATTGAAATACTtattacataaggaggatcgctatgttcctcaaacgtttagac g" /listShort="smc, ftsY" /GFF_Attribute="listLong" /label="upshifts" CDS 1578888..1582448 /gene="smc" /locus_tag="BSU_15940" /old_locus_tag="BSU15940" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:9701812, 12100548, 12682299, 12897137, 15987505, 16272394, 26904953, 28154080" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9701812, 12100548, 12682299, 12897137, 15987505, 16272394, 26904953, 28154080; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="chromosome condensation and segregation SMC ATPase" /protein_id="NP_389476.2" /db_xref="EnsemblGenomes-Gn:BSU15940" /db_xref="EnsemblGenomes-Tr:CAB13467" /db_xref="GOA:P51834" /db_xref="InterPro:IPR003395" /db_xref="InterPro:IPR010935" /db_xref="InterPro:IPR011890" /db_xref="InterPro:IPR024704" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036277" /db_xref="PDB:3ZGX" /db_xref="PDB:5H66" /db_xref="PDB:5H67" /db_xref="PDB:5NMO" /db_xref="PDB:5NNV" /db_xref="PDB:5XG3" /db_xref="SubtiList:BG11538" /db_xref="UniProtKB/Swiss-Prot:P51834" /translation="MFLKRLDVIGFKSFAERISVDFVKGVTAVVGPNGSGKSNITDAI RWVLGEQSARSLRGGKMEDIIFAGSDSRKRLNLAEVTLTLDNDDHFLPIDFHEVSVTR RVYRSGESEFLINNQPCRLKDIIDLFMDSGLGKEAFSIISQGKVEEILSSKAEDRRSI FEEAAGVLKYKTRKKKAENKLFETQDNLNRVEDILHELEGQVEPLKIQASIAKDYLEK KKELEHVEIALTAYDIEELHGKWSTLKEKVQMAKEEELAESSAISAKEAKIEDTRDKI QALDESVDELQQVLLVTSEELEKLEGRKEVLKERKKNAVQNQEQLEEAIVQFQQKETV LKEELSKQEAVFETLQAEVKQLRAQVKEKQQALSLHNENVEEKIEQLKSDYFELLNSQ ASIRNELQLLDDQMSQSAVTLQRLADNNEKHLQERHDISARKAACETEFARIEQEIHS QVGAYRDMQTKYEQKKRQYEKNESALYQAYQYVQQARSKKDMLETMQGDFSGFYQGVK EVLKAKERLGGIRGAVLELISTEQKYETAIEIALGASAQHVVTDDEQSARKAIQYLKQ NSFGRATFLPLSVIRDRQLQSRDAETAARHSSFLGVASELVTFDPAYRSVIQNLLGTV LITEDLKGANELAKLLGHRYRIVTLEGDVVNPGGSMTGGAVKKKNNSLLGRSRELEDV TKRLAEMEEKTALLEQEVKTLKHSIQDMEKKLADLRETGEGLRLKQQDVKGQLYELQV AEKNINTHLELYDQEKSALSESDEERKVRKRKLEEELSAVSEKMKQLEEDIDRLTKQK QTQSSTKESLSNELTELKIAAAKKEQACKGEEDNLARLKKELTETELALKEAKEDLSF LTSEMSSSTSGEEKLEEAAKHKLNDKTKTIELIALRRDQRIKLQHGLDTYERELKEMK RLYKQKTTLLKDEEVKLGRMEVELDNLLQYLREEYSLSFEGAKEKYQLETDPEEARKR VKLIKLAIEELGTVNLGSIDEFERVNERYKFLSEQKEDLTEAKNTLFQVIEEMDEEMT KRFNDTFVQIRSHFDQVFRSLFGGGRAELRLTDPNDLLHSGVEIIAQPPGKKLQNLNL LSGGERALTAIALLFSILKVRPVPFCVLDEVEAALDEANVFRFAQYLKKYSSDTQFIV ITHRKGTMEEADVLYGVTMQESGVSKVISVKLEETKEFVQ*" /label="smc CDS" gene 1578888..1582448 /gene="smc" /locus_tag="BSU_15940" /old_locus_tag="BSU15940" /label="smc gene" S_feature complement(1582382..1583452) /Source="Nicolas_S_feature" /locus_tag="new_1670054_1671124_c" /HighExp="Cold, C30, Gly, T0.30H, Pyr, T-4.40H, G135, Lbstat, Fru, T-5.40H" /AntisenseName="ftsY" /AntisenseCor="-3.7172405649441298E-3" /AntisenseRegPval=0 /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S578" CDS 1582468..1583457 /gene="ftsY" /locus_tag="BSU_15950" /old_locus_tag="BSU15950" /function="16.1: Circulate" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11021934, 11123669, 11166993, 12682299, 15995216, 16705751, 22056770" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11021934, 11123669, 11166993, 12682299, 15995216, 16705751, 22056770; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="signal recognition particle (docking protein)" /protein_id="NP_389477.1" /db_xref="EnsemblGenomes-Gn:BSU15950" /db_xref="EnsemblGenomes-Tr:CAB13468" /db_xref="GOA:P51835" /db_xref="InterPro:IPR000897" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004390" /db_xref="InterPro:IPR013822" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036225" /db_xref="SubtiList:BG11539" /db_xref="UniProtKB/Swiss-Prot:P51835" /translation="MSFFKKLKEKITKQTDSVSEKFKDGLEKTRNSFQNKVNDLVSRY RKVDEDFFEELEEVLISADVGFTTVMELIDELKKEVKRRNIQDPKEVQSVISEKLVEI YNSGDEQISELNIQDGRLNVILLVGVNGVGKTTTIGKLAHKMKQEGKSVVLAAGDTFR AGAIEQLEVWGERTGVPVIKQTAGSDPAAVIYDAVHAAKARNADVLICDTAGRLQNKV NLMKELEKVKRVIEREVPEAPHEVLLALDATTGQNAMAQAKEFSKATNVTGIALTKLD GTAKGGIVLAIRNELHIPVKLVGLGEKVDDLQEFDPESYVYGLFSDLVEKADD*" /label="ftsY CDS" gene 1582468..1583457 /gene="ftsY" /locus_tag="BSU_15950" /old_locus_tag="BSU15950" /label="ftsY gene" downshifts 1583444 /Source="Nicolas_upshifts" /id="D885" /incds=0 /nref=220 /ntot=261 /MaxReadThrough="2.98458" /MaxDrop="6.84303" /score="49.5808683" /energy="-14.4" /TU="NA" /idTUdmin="U1307" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1583494..1583979) /gene="ylqB" /locus_tag="BSU_15960" /old_locus_tag="BSU15960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15033535, 22287527" /codon_start=1 /transl_table=11 /product="conserved exported protein of unknown function" /protein_id="NP_389478.1" /db_xref="EnsemblGenomes-Gn:BSU15960" /db_xref="EnsemblGenomes-Tr:CAB13469" /db_xref="GOA:O31737" /db_xref="InterPro:IPR008969" /db_xref="InterPro:IPR008979" /db_xref="SubtiList:BG13401" /db_xref="UniProtKB/Swiss-Prot:O31737" /translation="MKKIGLLFMLCLAALFTIGFPAQQADAAEAPYKASITNISTDGG VYGKINYGQGQYWRVKYNITVSGKLLDQNGQPVPNAPVRFEADTKVGNTTQTASGTTD ANGTFEVPMYLGPAAGYYTYYTSVSVHYYDIIPFRVFSGESRLVSTDNSLYHFAYQVR R*" /label="ylqB CDS" gene complement(1583494..1583979) /gene="ylqB" /locus_tag="BSU_15960" /old_locus_tag="BSU15960" /label="ylqB gene" downshifts complement(1583497) /Source="Nicolas_upshifts" /id="D886" /incds=0 /nref=139 /ntot=244 /MaxReadThrough="6.77251" /MaxDrop="6.10895" /score="32.8428224" /energy="-14.4" /TU="U1311" /idTUdmin="U1311" /TUdmin="-1076" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1584001..1584019) /Source="Nicolas_upshift_promotors" /id="U1311" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2831 /SigmaFactorBS="tatcttgtcaaagcggcgattaacttttccaaaatacGCTAA ATAtcatccaatttatTCCGATATTGTATATGAACcctattttaaggaggatttttat g" /listShort="ylqB, S578" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1584017) /Source="Nicolas_upshifts" /id="U1311" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2831 /SigmaFactorBS="tatcttgtcaaagcggcgattaacttttccaaaatacGCTAA ATAtcatccaatttatTCCGATATTGTATATGAACcctattttaaggaggatttttat g" /listShort="ylqB, S578" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1584033..1584040) /Source="Nicolas_upshift_promotors" /id="U1311" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2831 /SigmaFactorBS="tatcttgtcaaagcggcgattaacttttccaaaatacGCTAA ATAtcatccaatttatTCCGATATTGTATATGAACcctattttaaggaggatttttat g" /listShort="ylqB, S578" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1584082..1584088 /Source="Nicolas_upshift_promotors" /id="U1312" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.709290709290709" /psig=1 /xcortree=2649 /SigmaFactorBS="tttggaaaagttaatcgccgctttgacaagataaaaaCTTGA CAgtgtcattaaaaccGTGTAAACTAAGTTATCGTAaagggatttgacttaacaaagg g" /listShort="ylxM, ffh, S579, rpsP, ylqC, S580, ylqD, rimM, trmD" /listLong="NA, rplS, S581, rbgA, rnhB, ylqG, ylqH, S582, sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1584103..1584122 /Source="Nicolas_upshift_promotors" /id="U1312" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.709290709290709" /psig=1 /xcortree=2649 /SigmaFactorBS="tttggaaaagttaatcgccgctttgacaagataaaaaCTTGA CAgtgtcattaaaaccGTGTAAACTAAGTTATCGTAaagggatttgacttaacaaagg g" /listShort="ylxM, ffh, S579, rpsP, ylqC, S580, ylqD, rimM, trmD" /listLong="NA, rplS, S581, rbgA, rnhB, ylqG, ylqH, S582, sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1584105 /Source="Nicolas_upshifts" /id="U1312" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.709290709290709" /psig=1 /xcortree=2649 /SigmaFactorBS="tttggaaaagttaatcgccgctttgacaagataaaaaCTTGA CAgtgtcattaaaaccGTGTAAACTAAGTTATCGTAaagggatttgacttaacaaagg g" /listShort="ylxM, ffh, S579, rpsP, ylqC, S580, ylqD, rimM, trmD" /listLong="NA, rplS, S581, rbgA, rnhB, ylqG, ylqH, S582, sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" CDS 1584156..1584488 /gene="ylxM" /locus_tag="BSU_15970" /old_locus_tag="BSU15970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11274114, 24659773; Product type f: factor" /codon_start=1 /transl_table=11 /product="component of the signal recognition particle (SRP) protein-targeting pathway" /protein_id="NP_389479.1" /db_xref="EnsemblGenomes-Gn:BSU15970" /db_xref="EnsemblGenomes-Tr:CAB13470" /db_xref="GOA:P37104" /db_xref="InterPro:IPR007394" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10829" /db_xref="UniProtKB/Swiss-Prot:P37104" /translation="MSLEKTTRMNYLFDFYQSLLTSKQKSYMSLYYLDDFSLGEIAEE YEVSRQAVYDNIKRTEAMLEQYEEKLLLLKKFQERKEMFNKLKELASGSKEEEEITAL IEALEKLD*" /label="ylxM CDS" gene 1584156..1584488 /gene="ylxM" /locus_tag="BSU_15970" /old_locus_tag="BSU15970" /label="ylxM gene" downshifts complement(1584159) /Source="Nicolas_upshifts" /id="D887" /incds=0 /nref=3 /ntot=52 /MaxReadThrough="1.40385" /MaxDrop="4.6092" /score="32.8428224" /energy="-14.4" /TU="NA" /idTUdmin="U1311" /TUdmin="-1738" /isTUend="FALSE" /label="downshifts" CDS 1584502..1585842 /gene="ffh" /locus_tag="BSU_15980" /old_locus_tag="BSU15980" /function="16.13: Shape" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7511896, 8662730, 10222262, 10224127, 10658653, 12682299, 11123669, 22056770, 26344568" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7511896, 8662730, 10222262, 10224127, 10658653, 12682299, 11123669, 22056770, 26344568; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="signal recognition particle-like (SRP) GTPase" /protein_id="NP_389480.1" /db_xref="EnsemblGenomes-Gn:BSU15980" /db_xref="EnsemblGenomes-Tr:CAB13471" /db_xref="GOA:P37105" /db_xref="InterPro:IPR000897" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004125" /db_xref="InterPro:IPR004780" /db_xref="InterPro:IPR013822" /db_xref="InterPro:IPR022941" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036891" /db_xref="PDB:4UE4" /db_xref="SubtiList:BG10830" /db_xref="UniProtKB/Swiss-Prot:P37105" /translation="MAFEGLADRLQQTISKIRGKGKVSEQDVKEMMREVRLALLEADV NFKVVKDFVKKVSERAVGQDVMKSLTPGQQVIKVVQEELTELMGGEESKIAVAKRPPT VIMMVGLQGAGKTTTSGKLANLLRKKHNRKPMLVAADIYRPAAIKQLETLGKQLDMPV FSLGDQVSPVEIAKQAIEKAKEEHYDYVILDTAGRLHIDHELMDELTNVKEIANPEEI FLVVDSMTGQDAVNVAKSFNEQLGLTGVVLTKLDGDTRGGAALSIRAVTNTPIKFAGL GEKLDALEPFHPERMASRILGMGDVLTLIEKAQASVDEDKAKELEQKMRTMSFTLDDF LEQLGQVRNMGPLDELLQMMPGAGKMKGLKNIQVDEKQLNHVEAIIKSMTVLEKEQPD IINASRRKRIAKGSGTSVQEVNRLLKQFDEMKKMMKQMTNMSKGKKKGFKLPFM*" /label="ffh CDS" gene 1584502..1585842 /gene="ffh" /locus_tag="BSU_15980" /old_locus_tag="BSU15980" /label="ffh gene" S_feature 1585843..1585947 /Source="Nicolas_S_feature" /locus_tag="new_1673515_1673619" /HighExp="Cold, G135, C30, G180, LPhT, HPh, Paraq, LPh, Oxctl, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S579" CDS 1585948..1586220 /gene="rpsP" /locus_tag="BSU_15990" /old_locus_tag="BSU15990" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6419023, 12682299, 20034956" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6419023, 12682299, 20034956; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S16 (BS17)" /protein_id="NP_389481.1" /db_xref="EnsemblGenomes-Gn:BSU15990" /db_xref="EnsemblGenomes-Tr:CAB13472" /db_xref="GOA:P21474" /db_xref="InterPro:IPR000307" /db_xref="InterPro:IPR020592" /db_xref="InterPro:IPR023803" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10831" /db_xref="UniProtKB/Swiss-Prot:P21474" /translation="MAVKIRLKRMGAKKSPFYRIVVADSRSPRDGRFIETVGTYNPVA KPAEVKIDEELALKWLQTGAKPSDTVRNLFSSQGIMEKFHNAKQGK*" /label="rpsP CDS" gene 1585948..1586220 /gene="rpsP" /locus_tag="BSU_15990" /old_locus_tag="BSU15990" /label="rpsP gene" CDS 1586220..1586465 /gene="ylqC" /locus_tag="BSU_16000" /old_locus_tag="BSU16000" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191, 22720735, 26483775; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative RNA binding protein" /protein_id="NP_389482.1" /db_xref="EnsemblGenomes-Gn:BSU16000" /db_xref="EnsemblGenomes-Tr:CAB13473" /db_xref="GOA:O31738" /db_xref="InterPro:IPR009019" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR020627" /db_xref="SubtiList:BG13402" /db_xref="UniProtKB/Swiss-Prot:O31738" /translation="MTDQHLEDLIVHIVTPLVDHPDDIRVIREETDQKIALRLSVHKS DTGKVIGKQGRTAKAIRTAVFAAGVQSSKKVQFEIFD*" /label="ylqC CDS" gene 1586220..1586465 /gene="ylqC" /locus_tag="BSU_16000" /old_locus_tag="BSU16000" /label="ylqC gene" downshifts 1586437 /Source="Nicolas_upshifts" /id="D888" /incds=0 /nref=41 /ntot=178 /MaxReadThrough="6.57974" /MaxDrop="4.803" /score="-7.01631592" /energy="-5.6" /TU="U1312" /idTUdmin="U1312" /TUdmin="-1804" /isTUend="FALSE" /label="downshifts" S_feature 1586482..1586586 /Source="Nicolas_S_feature" /locus_tag="new_1674154_1674258" /HighExp="G180, Oxctl, G150, G135, Paraq, LBGexp, H2O2, HPh, LPh, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S580" CDS 1586587..1586973 /gene="ylqD" /locus_tag="BSU_16010" /old_locus_tag="BSU16010" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389483.1" /db_xref="EnsemblGenomes-Gn:BSU16010" /db_xref="EnsemblGenomes-Tr:CAB13474" /db_xref="InterPro:IPR021297" /db_xref="SubtiList:BG13403" /db_xref="UniProtKB/Swiss-Prot:O31739" /translation="MQIIHRVAVMQVLTERSKEKLLASFAEKKQMLERECSQLYFQLR KHEKEQQNPNMIEQFKKAIEKRKDDIKIIDFQIAQVHTLPLGSELKEKEVDALLTIEA GDDWHEKTAANTIVIKDGKVIEIRQR*" /label="ylqD CDS" gene 1586587..1586973 /gene="ylqD" /locus_tag="BSU_16010" /old_locus_tag="BSU16010" /label="ylqD gene" CDS 1586978..1587502 /gene="rimM" /locus_tag="BSU_16020" /old_locus_tag="BSU16020" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15496525, 16014871, 27382067; Product type f: factor" /codon_start=1 /transl_table=11 /product="16S rRNA processing protein" /protein_id="NP_389484.1" /db_xref="EnsemblGenomes-Gn:BSU16020" /db_xref="EnsemblGenomes-Tr:CAB13475" /db_xref="GOA:O31740" /db_xref="InterPro:IPR002676" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR011033" /db_xref="InterPro:IPR011961" /db_xref="InterPro:IPR027275" /db_xref="InterPro:IPR036976" /db_xref="SubtiList:BG13404" /db_xref="UniProtKB/Swiss-Prot:O31740" /translation="MTKRWFNVGKIVNTHGIKGEVRVISKTDFAEERYKPGNTLYLFM DGRNEPVEVTVNTHRLHKQFHLLQFKERQNLNEVEELKNAIIKVPEEELGELNEGEFY FHEIIGCEVFTEEGELIGKVKEILTPGANDVWVIGRKGKKDALIPYIESVVKHIDVRE KKIEIELMEGLIDE*" /label="rimM CDS" gene 1586978..1587502 /gene="rimM" /locus_tag="BSU_16020" /old_locus_tag="BSU16020" /label="rimM gene" CDS 1587499..1588230 /gene="trmD" /locus_tag="BSU_16030" /old_locus_tag="BSU16030" /EC_number="2.1.1.228" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10094308, 11532950, 12682299, 12773376, 15060037, 27881678, 28601227; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA(m1G37)methyltransferase" /protein_id="NP_389485.1" /db_xref="EnsemblGenomes-Gn:BSU16030" /db_xref="EnsemblGenomes-Tr:CAB13476" /db_xref="GOA:O31741" /db_xref="InterPro:IPR002649" /db_xref="InterPro:IPR016009" /db_xref="InterPro:IPR029026" /db_xref="InterPro:IPR029028" /db_xref="SubtiList:BG12687" /db_xref="UniProtKB/Swiss-Prot:O31741" /translation="MKIDFLTLFPEMFEGVLGSSILQKAQEKDAVQFQVVNFREYSDN KHNTVDDYPYGGGAGMVLKPQPVFDAVEDLTSKAAAAPRIILVCPQGERFTQKKAEQL AKEEHLLFICGHYEGYDERIREHLVTDEISIGDFVLTGGELPAMMIADSVVRLLPGVL GKEASHIEDSFSTGLLEHPHYTRPADYKGLKVPETLLSGNHAKIEEWRNKESIRRTYL RRPDLLKDHPLTEQQRKWISEWEKE*" /label="trmD CDS" gene 1587499..1588230 /gene="trmD" /locus_tag="BSU_16030" /old_locus_tag="BSU16030" /label="trmD gene" promotor_-35 1588236..1588243 /Source="Nicolas_upshift_promotors" /id="U1313" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.822177822177822" /psig=1 /xcortree=2646 /SigmaFactorBS="aagtggatttctgaatgggaaaaagaatagattttATTGCAT AggctatgaaattgTGATAAGATACTACTTGTGGcttaagcgggcttatccgctgcaa g" /listShort="NA, rplS, S581, rbgA, rnhB, ylqG, ylqH, S582" /listLong="sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1588257..1588276 /Source="Nicolas_upshift_promotors" /id="U1313" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.822177822177822" /psig=1 /xcortree=2646 /SigmaFactorBS="aagtggatttctgaatgggaaaaagaatagattttATTGCAT AggctatgaaattgTGATAAGATACTACTTGTGGcttaagcgggcttatccgctgcaa g" /listShort="NA, rplS, S581, rbgA, rnhB, ylqG, ylqH, S582" /listLong="sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1588261 /Source="Nicolas_upshifts" /id="U1313" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.822177822177822" /psig=1 /xcortree=2646 /SigmaFactorBS="aagtggatttctgaatgggaaaaagaatagattttATTGCAT AggctatgaaattgTGATAAGATACTACTTGTGGcttaagcgggcttatccgctgcaa g" /listShort="NA, rplS, S581, rbgA, rnhB, ylqG, ylqH, S582" /listLong="sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" misc_RNA 1588309..1588350 /locus_tag="BSU_misc_RNA_30" /product="L19_leader" /label="L19 leader RNA" gene 1588309..1588350 /locus_tag="BSU_misc_RNA_30" /label="gene" CDS 1588370..1588717 /gene="rplS" /locus_tag="BSU_16040" /old_locus_tag="BSU16040" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 16272117, 27477481; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L19" /protein_id="NP_389486.2" /db_xref="EnsemblGenomes-Gn:BSU16040" /db_xref="EnsemblGenomes-Tr:CAB13477" /db_xref="GOA:O31742" /db_xref="InterPro:IPR001857" /db_xref="InterPro:IPR008991" /db_xref="InterPro:IPR018257" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG12667" /db_xref="UniProtKB/Swiss-Prot:O31742" /translation="MQKLIEDITKEQLRTDLPAFRPGDTLRVHVKVVEGNRERIQIFE GVVIKRRGGGISETFTVRKISYGVGVERTFPVHTPKIAKIEVVRYGKVRRAKLYYLRE LRGKAARIKEIRR*" /label="rplS CDS" gene 1588370..1588717 /gene="rplS" /locus_tag="BSU_16040" /old_locus_tag="BSU16040" /label="rplS gene" downshifts 1588719 /Source="Nicolas_upshifts" /id="D889" /incds=0 /nref=212 /ntot=274 /MaxReadThrough="6.00308" /MaxDrop="9.06015" /score="23.9942041" /energy="-12.6" /TU="U1313" /idTUdmin="U1312" /TUdmin=478 /isTUend="FALSE" /label="downshifts" promotor_-35 1588772..1588778 /Source="Nicolas_upshift_promotors" /id="U1314" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.496503496503497" /psig="0.995004995004995" /xcortree=2756 /SigmaFactorBS="aaagagcttgttacctgtaacaagctctttttttatacagaA TTTGAAaatgccggacaggCATCGTAAAATACATAAAGGacaacaatgaatcatgcat a" /listShort="S581, rbgA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1588791..1588859 /Source="Nicolas_S_feature" /locus_tag="new_1676463_1676531" /HighExp="Oxctl, G180, Paraq, G135, H2O2, LBGstat, dia15, G150, HPh, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.149563" /TUshortSig="SigA, SigA" /TUshortPSig="0.995, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S581" upshifts 1588791 /Source="Nicolas_upshifts" /id="U1314" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.496503496503497" /psig="0.995004995004995" /xcortree=2756 /SigmaFactorBS="aaagagcttgttacctgtaacaagctctttttttatacagaA TTTGAAaatgccggacaggCATCGTAAAATACATAAAGGacaacaatgaatcatgcat a" /listShort="S581, rbgA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1588792..1588811 /Source="Nicolas_upshift_promotors" /id="U1314" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.496503496503497" /psig="0.995004995004995" /xcortree=2756 /SigmaFactorBS="aaagagcttgttacctgtaacaagctctttttttatacagaA TTTGAAaatgccggacaggCATCGTAAAATACATAAAGGacaacaatgaatcatgcat a" /listShort="S581, rbgA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1588860..1589708 /gene="rbgA" /locus_tag="BSU_16050" /old_locus_tag="BSU16050" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 16390447, 16431913, 16997968, 17613524, 22267738, 25330043, 26951678" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16390447, 16431913, 16997968, 17613524, 22267738, 25330043, 26951678; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosome biogenesis GTPase A" /protein_id="NP_389487.1" /db_xref="EnsemblGenomes-Gn:BSU16050" /db_xref="EnsemblGenomes-Tr:CAB13478" /db_xref="GOA:O31743" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR016478" /db_xref="InterPro:IPR019991" /db_xref="InterPro:IPR023179" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030378" /db_xref="PDB:1PUJ" /db_xref="SubtiList:BG13405" /db_xref="UniProtKB/Swiss-Prot:O31743" /translation="MTIQWFPGHMAKARREVTEKLKLIDIVYELVDARIPMSSRNPMI EDILKNKPRIMLLNKADKADAAVTQQWKEHFENQGIRSLSINSVNGQGLNQIVPASKE ILQEKFDRMRAKGVKPRAIRALIIGIPNVGKSTLINRLAKKNIAKTGDRPGITTSQQW VKVGKELELLDTPGILWPKFEDELVGLRLAVTGAIKDSIINLQDVAVFGLRFLEEHYP ERLKERYGLDEIPEDIAELFDAIGEKRGCLMSGGLINYDKTTEVIIRDIRTEKFGRLS FEQPTM*" /label="rbgA CDS" gene 1588860..1589708 /gene="rbgA" /locus_tag="BSU_16050" /old_locus_tag="BSU16050" /label="rbgA gene" promotor_-35 1589729..1589736 /Source="Nicolas_upshift_promotors" /id="U1315" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2823 /SigmaFactorBS="gacgatgtaaaggcgcgcagaaatgcgggtCTTTATTTtttc ttggctgaACCGATACATACAGTAAGGgagaagagaaagtgaatacattaaccgtaaa g" /listShort="rnhB, ylqG, ylqH, S582" /listLong="sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1589749..1589767 /Source="Nicolas_upshift_promotors" /id="U1315" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2823 /SigmaFactorBS="gacgatgtaaaggcgcgcagaaatgcgggtCTTTATTTtttc ttggctgaACCGATACATACAGTAAGGgagaagagaaagtgaatacattaaccgtaaa g" /listShort="rnhB, ylqG, ylqH, S582" /listLong="sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1589759 /Source="Nicolas_upshifts" /id="U1315" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2823 /SigmaFactorBS="gacgatgtaaaggcgcgcagaaatgcgggtCTTTATTTtttc ttggctgaACCGATACATACAGTAAGGgagaagagaaagtgaatacattaaccgtaaa g" /listShort="rnhB, ylqG, ylqH, S582" /listLong="sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" CDS 1589779..1590546 /gene="rnhB" /locus_tag="BSU_16060" /old_locus_tag="BSU16060" /EC_number="3.1.26.4" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10094689, 12475934, 23882084, 23937561, 29078353" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094689, 12475934, 23882084, 23937561, 29078353; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease HII" /protein_id="NP_389488.1" /db_xref="EnsemblGenomes-Gn:BSU16060" /db_xref="EnsemblGenomes-Tr:CAB13479" /db_xref="GOA:O31744" /db_xref="InterPro:IPR001352" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR022898" /db_xref="InterPro:IPR024567" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG12666" /db_xref="UniProtKB/Swiss-Prot:O31744" /translation="MNTLTVKDIKDRLQEVKDAQDPFIAQCENDPRKSVQTLVEQWLK KQAKEKALKEQWVNMTSYERLARNKGFRLIAGVDEVGRGPLAGPVVASAVILPEECEI LGLTDSKKLSEKKREEYYELIMKEALAVGIGIVEATVIDEINIYEASKMAMVKAIQDL SDTPDYLLVDAMTLPLDTAQASIIKGDAKSVSIAAGACIAKVTRDRMMSAYAETYPMY GFEKNKGYGTKEHLEALAAYGPTELHRKTFAPVQSFR*" /label="rnhB CDS" gene 1589779..1590546 /gene="rnhB" /locus_tag="BSU_16060" /old_locus_tag="BSU16060" /label="rnhB gene" CDS 1590578..1592308 /gene="ylqG" /locus_tag="BSU_16070" /old_locus_tag="BSU16070" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_389489.1" /db_xref="EnsemblGenomes-Gn:BSU16070" /db_xref="EnsemblGenomes-Tr:CAB13480" /db_xref="SubtiList:BG13406" /db_xref="UniProtKB/Swiss-Prot:O31745" /translation="MNIRNDVQKALQHLFGRTAVPQETSKVNEALNGEKRLLLGKVLR LLGDQHALIQVGNQTVQGKLETQLRPQAYYWFSYEKKTAEQTGRLQVVQSFDQNPKTI QDAAGKLLNAISVKTSNAALMMTGAMLKSKTPVTENDIKTAVRWMDTLPSQDTKKAVE TVLFALKRDLPIHSEILNGVHAVKSPVPLHQHVSQLLQAIDQNPQQSQMMSKLKEAVT VLLNSEIDVHAERLIDKLISLTDNTKAPSPTNTAGSRELSTPAGSPGKASLPIANHTA EQGSIQEEPVKTAADIPIKEARQLLVKLTESAEKNSLQIVKEAANWIKAAASSGDSKS LAASAVLQAAQVTDQEAEVFLKAVQQTAPHLADKADVLSFLSKVKTAIGARDEVAFIK AFEQGSAVTSGEMQSIKLALSALRASHEVAEPVKQEADQLFHKLNGQLFMQQDHPSYS QIVMSFPMFSKSGVQDMTVLFKGKKEADGKLDPSHCRLLFLLQLDTLKETVVDCLVQQ KVMTITIETDFELQAAIDPMVPALKQGLKEMGYSLSGVNAKKRVHTEEKASIDQYITS ISDQEVDVKI*" /label="ylqG CDS" gene 1590578..1592308 /gene="ylqG" /locus_tag="BSU_16070" /old_locus_tag="BSU16070" /label="ylqG gene" upshifts complement(1591815) /Source="Nicolas_upshifts" /id="U1316" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.78921078921079" /psig="0.827172827172827" /xcortree=1797 /SigmaFactorBS="aaaagctgatcggcttctTGTTTGACtggttcggctacctCA TGCGATGCTCTTAAGGCAgaaagagccagcttgatggattgcatttcgccagatgtga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1591816..1591835) /Source="Nicolas_upshift_promotors" /id="U1316" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.78921078921079" /psig="0.827172827172827" /xcortree=1797 /SigmaFactorBS="aaaagctgatcggcttctTGTTTGACtggttcggctacctCA TGCGATGCTCTTAAGGCAgaaagagccagcttgatggattgcatttcgccagatgtga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1591850..1591857) /Source="Nicolas_upshift_promotors" /id="U1316" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.78921078921079" /psig="0.827172827172827" /xcortree=1797 /SigmaFactorBS="aaaagctgatcggcttctTGTTTGACtggttcggctacctCA TGCGATGCTCTTAAGGCAgaaagagccagcttgatggattgcatttcgccagatgtga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1592305..1592586 /gene="ylqH" /locus_tag="BSU_16080" /old_locus_tag="BSU16080" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative flagellar biosynthesis protein" /protein_id="NP_389490.1" /db_xref="EnsemblGenomes-Gn:BSU16080" /db_xref="EnsemblGenomes-Tr:CAB13481" /db_xref="GOA:O34867" /db_xref="InterPro:IPR004683" /db_xref="InterPro:IPR006135" /db_xref="InterPro:IPR029025" /db_xref="SubtiList:BG13407" /db_xref="UniProtKB/Swiss-Prot:O34867" /translation="MKEQTPIRKAVALHYDEQKDKAPRVIATGKGHVADNIIKEAKKA GVPIQEDRTLVELMRHLTVDDQIPEALYETVAEIFSFIYKLDESVKNKK*" /label="ylqH CDS" gene 1592305..1592586 /gene="ylqH" /locus_tag="BSU_16080" /old_locus_tag="BSU16080" /label="ylqH gene" downshifts 1592418 /Source="Nicolas_upshifts" /id="D890" /incds=1 /nref=7 /ntot=136 /MaxReadThrough="4.03339" /MaxDrop="4.52065" /score="-6.81136789" /energy="-9.2" /TU="U1313,U1315" /idTUdmin="U1313" /TUdmin="-267" /isTUend="FALSE" /label="downshifts" S_feature 1592587..1592706 /Source="Nicolas_S_feature" /locus_tag="new_1680259_1680378" /HighExp="Cold, Lbstat, H2O2, Glu, Paraq, Mal, G135, GM 90, Oxctl, Fru" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA" /TUshortPSig="1, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S582" promotor_-35 1592678..1592685 /Source="Nicolas_upshift_promotors" /id="U1317" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.55044955044955" /psig="0.999000999001" /xcortree=2227 /SigmaFactorBS="ttagaaggattaaaagattttgcatcgaacTGTAGACAattc ttccagtatTATTATAGAATGAAAGCGCAgtctattttagttttgttacataagttag g" /listShort="sucC, sucD, dprA, S583, topA" /listLong="trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1592699..1592718 /Source="Nicolas_upshift_promotors" /id="U1317" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.55044955044955" /psig="0.999000999001" /xcortree=2227 /SigmaFactorBS="ttagaaggattaaaagattttgcatcgaacTGTAGACAattc ttccagtatTATTATAGAATGAAAGCGCAgtctattttagttttgttacataagttag g" /listShort="sucC, sucD, dprA, S583, topA" /listLong="trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1592708 /Source="Nicolas_upshifts" /id="U1317" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.55044955044955" /psig="0.999000999001" /xcortree=2227 /SigmaFactorBS="ttagaaggattaaaagattttgcatcgaacTGTAGACAattc ttccagtatTATTATAGAATGAAAGCGCAgtctattttagttttgttacataagttag g" /listShort="sucC, sucD, dprA, S583, topA" /listLong="trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" CDS 1592759..1593916 /gene="sucC" /locus_tag="BSU_16090" /old_locus_tag="BSU16090" /EC_number="6.2.1.4" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 2548486, 22720735, 22751660; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="succinyl-CoA synthetase (beta subunit)" /protein_id="NP_389491.1" /db_xref="EnsemblGenomes-Gn:BSU16090" /db_xref="EnsemblGenomes-Tr:CAB13482" /db_xref="GOA:P80886" /db_xref="InterPro:IPR005809" /db_xref="InterPro:IPR005811" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR013650" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016102" /db_xref="InterPro:IPR017866" /db_xref="SubtiList:BG12680" /db_xref="UniProtKB/Swiss-Prot:P80886" /translation="MNIHEYQGKEVLRKYGVSVPEGKVAFTAEEAVESAKSLSSSVYV VKAQIHAGGRGKAGGVKIAKSLDEVKAYAEELLGKTLVTHQTGPDGQVIKRLLIEEGC DIKKEYYIGLVLDRATSRIVLMASEEGGTEIEEVAEKTPEKIKKAVIDPAVGLQGYQA REIAFAINIPKELVGKAAKFMLGLYKAFVEKDCSIAEINPLVVTGDGNVMALDAKLNF DSNALYRQKDIMEYRDLDEEDPKEIEASKYDLSYISLDGNIGCMVNGAGLAMSTMDII KHYGGEPANFLDVGGGATAEKVTEAFKIILSDQNVKGIFVNIFGGIMKCDVIAEGVVE ATRQVGLTLPLVVRLEGTNVDLGKKILSESGLNITSAESMADGAQKIVSLV*" /label="sucC CDS" gene 1592759..1593916 /gene="sucC" /locus_tag="BSU_16090" /old_locus_tag="BSU16090" /label="sucC gene" promotor_no_box complement(1592831..1592931) /Source="Nicolas_upshift_promotors" /id="U1318" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.864135864135864" /psig="0.0929070929070929" /xcortree=73 /SigmaFactorBS="ccagctttgcctcgaccgccagcatgaatttgagcctttacg acataaaccgagctggataagctctttgcactctcaactgcttcttctgctgtaaaag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1592871) /Source="Nicolas_upshifts" /id="U1318" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.864135864135864" /psig="0.0929070929070929" /xcortree=73 /SigmaFactorBS="ccagctttgcctcgaccgccagcatgaatttgagcctttacg acataaaccgagctggataagctctttgcactctcaactgcttcttctgctgtaaaag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1593945..1594847 /gene="sucD" /locus_tag="BSU_16100" /old_locus_tag="BSU16100" /EC_number="6.2.1.4" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 9643546, 22720735, 22751660; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="succinyl-CoA synthetase (alpha subunit)" /protein_id="NP_389492.1" /db_xref="EnsemblGenomes-Gn:BSU16100" /db_xref="EnsemblGenomes-Tr:CAB13483" /db_xref="GOA:P80865" /db_xref="InterPro:IPR003781" /db_xref="InterPro:IPR005810" /db_xref="InterPro:IPR005811" /db_xref="InterPro:IPR016102" /db_xref="InterPro:IPR017440" /db_xref="InterPro:IPR033847" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12681" /db_xref="UniProtKB/Swiss-Prot:P80865" /translation="MSVFINKDTRVIVQGITGSTALFHTKQMLEYGTNIVGGVTPGKG GTEAEGVPVFNTVAEAVQTTGANASVIYVPAPFAADAIMEAVDAELDLVICITEHIPV LDMVKVKRFMEGKKTRLIGPNCPGVITPEECKIGIMPGYIHKKGHVGVVSRSGTLTYE AVHQLSEAGVGQSTAVGIGGDPVNGTNFIDVLKAFNEDPDTHAVIMIGEIGGTAEEEA AEWVKANMTKPVVGFIGGKTAPPGKRMGHAGAIISGGKGTADEKIKTLNACGIEVAET PSVMGETLIKVLKEKNLFETCKTH*" /label="sucD CDS" gene 1593945..1594847 /gene="sucD" /locus_tag="BSU_16100" /old_locus_tag="BSU16100" /label="sucD gene" downshifts 1594837 /Source="Nicolas_upshifts" /id="D891" /incds=0 /nref=94 /ntot=208 /MaxReadThrough="5.40077" /MaxDrop="4.8878" /score="9.51199539" /energy="-15" /TU="U1317" /idTUdmin="U1315" /TUdmin=2130 /isTUend="FALSE" /label="downshifts" CDS 1594908..1595801 /gene="dprA" /locus_tag="BSU_16110" /old_locus_tag="BSU16110" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16014871, 16978360, 17803906, 18045469, 7768823, 23779106, 25138221, 28618091" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16014871, 16978360, 17803906, 18045469, 7768823, 23779106, 25138221, 28618091; Product type f: factor" /codon_start=1 /transl_table=11 /product="DNA processing Smf single strand binding protein" /protein_id="NP_389493.1" /db_xref="EnsemblGenomes-Gn:BSU16110" /db_xref="EnsemblGenomes-Tr:CAB13484" /db_xref="GOA:P39813" /db_xref="InterPro:IPR003488" /db_xref="SubtiList:BG11006" /db_xref="UniProtKB/Swiss-Prot:P39813" /translation="MDQAAVCLTICRINQLLSPSLLLKWWKADPSMSLTSPVLQTVTR DQIKAAALKNEIEQFYPKLPRVLAAYREQGINTIPISSKQYPFWLKSIYDPPAVLFAK GDMTLLSKGRKIGIVGTRNPTAYGKQVVNHLTKEICRKGWVIVSGLASGIDGMSHAAS IKAKGRTIGVIAGGFQHIYPRENLQLADHMAKHHILLSEHPPETKPQKWHFPMRNRII SGLSEGVIVVQGKEKSGSLITAYQALEQGREVFAVPGSLFDPYAGGPIKLIQQGAKAI WSAEDIFEELPERNVQYTEPF*" /label="dprA CDS" gene 1594908..1595801 /gene="dprA" /locus_tag="BSU_16110" /old_locus_tag="BSU16110" /label="dprA gene" promotor_-35 1595807..1595814 /Source="Nicolas_upshift_promotors" /id="U1319" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.839160839160839" /psig=1 /xcortree=1880 /SigmaFactorBS="acgttcaatatacggaacccttttgaattatCGTTTGACaaa cggtattgtaaTATTTAATAATAGTGAGGATttaaagttgcatattgttttctattta a" /listShort="S583, topA, trmFO" /listLong="codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1595829..1595848 /Source="Nicolas_upshift_promotors" /id="U1319" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.839160839160839" /psig=1 /xcortree=1880 /SigmaFactorBS="acgttcaatatacggaacccttttgaattatCGTTTGACaaa cggtattgtaaTATTTAATAATAGTGAGGATttaaagttgcatattgttttctattta a" /listShort="S583, topA, trmFO" /listLong="codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" S_feature 1595836..1595988 /Source="Nicolas_S_feature" /locus_tag="new_1683508_1683660" /HighExp="dia15, H2O2, G/S, Paraq, Diami, S1, Oxctl, LBGexp, C30, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.111279" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="SigD, SigA, SigA" /TUlongPSig="1, 1, 1" /label="S583" upshifts 1595836 /Source="Nicolas_upshifts" /id="U1319" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.839160839160839" /psig=1 /xcortree=1880 /SigmaFactorBS="acgttcaatatacggaacccttttgaattatCGTTTGACaaa cggtattgtaaTATTTAATAATAGTGAGGATttaaagttgcatattgttttctattta a" /listShort="S583, topA, trmFO" /listLong="codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" CDS 1595989..1598064 /gene="topA" /locus_tag="BSU_16120" /old_locus_tag="BSU16120" /EC_number="5.99.1.2" /function="16.3: Control" /function="16.6: Maintain" /function="16.9: Replicate" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9580687, 12682299, 16585761, 23133654" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9580687, 12682299, 16585761, 23133654; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA topoisomerase I" /protein_id="NP_389494.1" /db_xref="EnsemblGenomes-Gn:BSU16120" /db_xref="EnsemblGenomes-Tr:CAB13485" /db_xref="GOA:P39814" /db_xref="InterPro:IPR000380" /db_xref="InterPro:IPR003601" /db_xref="InterPro:IPR003602" /db_xref="InterPro:IPR005733" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR013497" /db_xref="InterPro:IPR013498" /db_xref="InterPro:IPR013825" /db_xref="InterPro:IPR023405" /db_xref="InterPro:IPR023406" /db_xref="InterPro:IPR028612" /db_xref="InterPro:IPR034149" /db_xref="SubtiList:BG11007" /db_xref="UniProtKB/Swiss-Prot:P39814" /translation="MSDYLVIVESPAKAKTIERYLGKKYKVKASMGHVRDLPKSQMGV DIEQNFEPKYITIRGKGPVLKELKTAAKKAKKVYLAADPDREGEAIAWHLAHSLDLDL NSDCRVVFNEITKDAIKESFKHPRMINMDLVDAQQARRILDRLVGYKISPILWKKVKK GLSAGRVQSVALRLIIDREKEINDFKPEEYWTIDGTFLKGQETFEASFFGKNGKKLPL NSEADVKEILSQLKGNQYTVEKVTKKERKRNPALPFTTSTLQQEAARKLNFRAKKTMM IAQQLYEGIDLGREGTVGLITYMRTDSTRISNTAVDEAAAFIDQTYGKEFLGGKRKPA KKNENAQDAHEAIRPTSVLRKPSELKAVLGRDQMRLYKLIWERFVASQMAPAVLDTMS VDLTNNGLTFRANGSKVKFSGFMKVYVEGKDDQMEEKDRMLPDLQEGDTVLSKDIEPE QHFTQPPPRYTEARLVKTLEERGIGRPSTYAPTLDTIQRRGYVALDNKRFVPTELGQI VLDLIMEFFPEIINVEFTAKMERDLDHVEEGNTEWVKIIDNFYTDFEKRVKKAESEMK EVEIEPEYAGEDCELCSSPMVYKMGRYGKFLACSNFPDCRNTKPIVKQIGVKCPSCGE GNIVERKSKKKRVFYGCDRYPDCEFVSWDKPIERKCPKCGKMLVEKKLKKGIQVQCVE CDYKEEPQK*" /label="topA CDS" gene 1595989..1598064 /gene="topA" /locus_tag="BSU_16120" /old_locus_tag="BSU16120" /label="topA gene" downshifts 1598034 /Source="Nicolas_upshifts" /id="D892" /incds=0 /nref=48 /ntot=173 /MaxReadThrough="5.66787" /MaxDrop="4.5486" /score="0.939045188" /energy="-13.2" /TU="U1319" /idTUdmin="U1317" /TUdmin="-19" /isTUend="TRUE" /label="downshifts" promotor_-35 1598096..1598101 /Source="Nicolas_upshift_promotors" /id="U1320" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.588411588411588" /psig="0.588411588411588" /xcortree=1017 /SigmaFactorBS="aagaaccacagaagtagcggtgagcagggtcttgctcacctt ctttgtGTGTTAaaagaaggccttgaaTAATAAACTAGGAGATGTGaaagatgaacca a" /listShort="trmFO, codV, clpQ, clpY, codY" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1598108 /Source="Nicolas_upshifts" /id="U1320" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.588411588411588" /psig="0.588411588411588" /xcortree=1017 /SigmaFactorBS="aagaaccacagaagtagcggtgagcagggtcttgctcacctt ctttgtGTGTTAaaagaaggccttgaaTAATAAACTAGGAGATGTGaaagatgaacca a" /listShort="trmFO, codV, clpQ, clpY, codY" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1598117..1598135 /Source="Nicolas_upshift_promotors" /id="U1320" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.588411588411588" /psig="0.588411588411588" /xcortree=1017 /SigmaFactorBS="aagaaccacagaagtagcggtgagcagggtcttgctcacctt ctttgtGTGTTAaaagaaggccttgaaTAATAAACTAGGAGATGTGaaagatgaacca a" /listShort="trmFO, codV, clpQ, clpY, codY" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1598140..1599447 /gene="trmFO" /locus_tag="BSU_16130" /old_locus_tag="BSU16130" /EC_number="2.1.1.74" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16027442, 21561081, 23095745, 23157377, 27825927, 28745052" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16027442, 21561081, 23095745, 23157377, 27825927, 28745052; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="tRNA:m(5)U-54 methyltransferase" /protein_id="NP_389495.1" /db_xref="EnsemblGenomes-Gn:BSU16130" /db_xref="EnsemblGenomes-Tr:CAB13486" /db_xref="GOA:P39815" /db_xref="InterPro:IPR002218" /db_xref="InterPro:IPR004417" /db_xref="InterPro:IPR020595" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG11008" /db_xref="UniProtKB/Swiss-Prot:P39815" /translation="MNQQTVNVIGAGLAGSEAAWQLAKRGIQVKLYEMRPVKQTPAHH TDKFAELVCSNSLRSNTLANAVGVLKEEMRALDSAIIAAADECSVPAGGALAVDRHEF AASVTNRVKNHPNVTVINEEVTEIPEGPTIIATGPLTSESLSAQLKELTGEDYLYFYD AAAPIVEKDSLDMDKVYLKSRYDKGEAAYLNCPMTEEEFDRFHEALTSAETVPLKEFE KEIFFEGCMPIEVMAKRGKKTMLFGPMKPVGLEHPVTGKRPYAVVQLRQDDAAGTLYN IVGFQTHLKWGDQKEVLKLIPGLENVEIVRYGVMHRNTFINSPSLLKPTYQFKNRSDL FFAGQMTGVEGYVESAASGLVAGINAAKLVLGEELVIFPQETAIGSMAHYITTTNQKN FQPMNANFGLLKELPVKIKNKKERNEQYANRAIETIQTISKTI*" /label="trmFO CDS" gene 1598140..1599447 /gene="trmFO" /locus_tag="BSU_16130" /old_locus_tag="BSU16130" /label="trmFO gene" promotor_-35 1599453..1599457 /Source="Nicolas_upshift_promotors" /id="U1321" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.626373626373626" /psig="0.998001998001998" /xcortree=2482 /SigmaFactorBS="caaacaatttcgaaaacaatataggtattGATTGcaacctga gcgcgattTGTGATACCATTTAAAAGCCcttcctggggaggtattaggcatggagaat g" /listShort="codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD" /listLong="ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1599474..1599493 /Source="Nicolas_upshift_promotors" /id="U1321" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.626373626373626" /psig="0.998001998001998" /xcortree=2482 /SigmaFactorBS="caaacaatttcgaaaacaatataggtattGATTGcaacctga gcgcgattTGTGATACCATTTAAAAGCCcttcctggggaggtattaggcatggagaat g" /listShort="codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD" /listLong="ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1599484 /Source="Nicolas_upshifts" /id="U1321" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.626373626373626" /psig="0.998001998001998" /xcortree=2482 /SigmaFactorBS="caaacaatttcgaaaacaatataggtattGATTGcaacctga gcgcgattTGTGATACCATTTAAAAGCCcttcctggggaggtattaggcatggagaat g" /listShort="codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD" /listLong="ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" CDS 1599515..1600429 /gene="codV" /locus_tag="BSU_16140" /old_locus_tag="BSU16140" /function="16.9: Replicate" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10498718, 11208805, 16553881, 16597952, 21239579" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10498718, 11208805, 16553881, 16597952, 21239579; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="site-specific tyrosine recombinase for chromosome partitioning" /protein_id="NP_389496.1" /db_xref="EnsemblGenomes-Gn:BSU16140" /db_xref="EnsemblGenomes-Tr:CAB13487" /db_xref="GOA:P39776" /db_xref="InterPro:IPR002104" /db_xref="InterPro:IPR004107" /db_xref="InterPro:IPR010998" /db_xref="InterPro:IPR011010" /db_xref="InterPro:IPR011931" /db_xref="InterPro:IPR013762" /db_xref="InterPro:IPR023009" /db_xref="SubtiList:BG10965" /db_xref="UniProtKB/Swiss-Prot:P39776" /translation="MENVKNFVKLFVEYLQIEKNYSQYTIVNYVDSIEEFETFLRVQG INGFEEAAYQDTRIFLTEAYEKGLSRRTISKKISALRSFYKFLMREKLIEENPFQLVH LPKQEKRIPKFLYQKELEELFEVSDISQPAGMRDQALLELLYATGMRVSECCSITIND VDLFMDTVLVHGKGKKQRYIPFGSYAREALKVYMNSGRQCLLMKAKEPHDLLFVNQRG GPLTARGIRHILSGLVQKASSTLHIHPHMLRHTFATHLLNEGADLRSVQELLGHSNLS STQIYTHVSKEMLRNTYMSHHPRAFKKN*" /label="codV CDS" gene 1599515..1600429 /gene="codV" /locus_tag="BSU_16140" /old_locus_tag="BSU16140" /label="codV gene" promotor_-35 1599554..1599558 /Source="Nicolas_upshift_promotors" /id="U1322" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.525474525474525" /psig="0.994005994005994" /xcortree=2472 /SigmaFactorBS="aggcatggagaatgttaagaatttcgtaaagttattcgttga aTATTTacaaattgaaaaaaaTTATTCACAATATACTATTGtgaattatgtggattca a" /listShort="clpQ, clpY, codY, S584" /listLong="flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC" /label="promotor_-35" upshifts 1599571 /Source="Nicolas_upshifts" /id="U1322" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.525474525474525" /psig="0.994005994005994" /xcortree=2472 /SigmaFactorBS="aggcatggagaatgttaagaatttcgtaaagttattcgttga aTATTTacaaattgaaaaaaaTTATTCACAATATACTATTGtgaattatgtggattca a" /listShort="clpQ, clpY, codY, S584" /listLong="flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC" /label="upshifts" promotor_-10 1599574..1599593 /Source="Nicolas_upshift_promotors" /id="U1322" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.525474525474525" /psig="0.994005994005994" /xcortree=2472 /SigmaFactorBS="aggcatggagaatgttaagaatttcgtaaagttattcgttga aTATTTacaaattgaaaaaaaTTATTCACAATATACTATTGtgaattatgtggattca a" /listShort="clpQ, clpY, codY, S584" /listLong="flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC" /label="promotor_-10" CDS 1600442..1600987 /gene="clpQ" /locus_tag="BSU_16150" /old_locus_tag="BSU16150" /EC_number="3.4.25.2" /function="16.6: Maintain" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11179218, 12032294, 12805205, 15983416, 17979190, 18689473, 21546913" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11179218, 12032294, 12805205, 15983416, 17979190, 18689473, 21546913; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="two-component ATP-dependent protease (N-terminalserine protease)" /protein_id="NP_389497.1" /db_xref="EnsemblGenomes-Gn:BSU16150" /db_xref="EnsemblGenomes-Tr:CAB13488" /db_xref="GOA:P39070" /db_xref="InterPro:IPR001353" /db_xref="InterPro:IPR022281" /db_xref="InterPro:IPR023333" /db_xref="InterPro:IPR029055" /db_xref="PDB:1YYF" /db_xref="PDB:2Z3A" /db_xref="PDB:2Z3B" /db_xref="SubtiList:BG10966" /db_xref="UniProtKB/Swiss-Prot:P39070" /translation="MSSFHATTIFAVQHKGRSAMSGDGQVTFGQAVVMKHTARKVRKL FNGKVLAGFAGSVADAFTLFEKFEAKLEEYNGNLKRAAVELAKEWRSDKVLRKLEAML IVMNQDTLLLVSGTGEVIEPDDGILAIGSGGNYALAAGRALKKHAGESMSASEIARAA LETAGEICVYTNDQIILEELE*" /label="clpQ CDS" gene 1600442..1600987 /gene="clpQ" /locus_tag="BSU_16150" /old_locus_tag="BSU16150" /label="clpQ gene" CDS 1601004..1602407 /gene="clpY" /locus_tag="BSU_16160" /old_locus_tag="BSU16160" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11179218, 12032294, 12805205, 15983416, 17979190, 18689473, 21546913" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11179218, 12032294, 12805205, 15983416, 17979190, 18689473, 21546913; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="two-component ATP-dependent protease (ATPase andchaperone)" /protein_id="NP_389498.1" /db_xref="EnsemblGenomes-Gn:BSU16160" /db_xref="EnsemblGenomes-Tr:CAB13489" /db_xref="GOA:P39778" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR004491" /db_xref="InterPro:IPR019489" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10967" /db_xref="UniProtKB/Swiss-Prot:P39778" /translation="MEKKPLTPRQIVDRLDQYIVGQQNAKKAVAVALRNRYRRSLLDE KLKDEVVPKNILMMGPTGVGKTEIARRIAKLSGAPFIKIEATKFTEVGYVGRDVESMV RDLVETSVRLIKEEKMNEVKEQAEENANKRIVRLLVPGKKKQSGVKNPFEMFFGGSQP NGEDEAESQEEANIEEKRKRMAHQLALGELEDYYVTVEVEEQQPSMFDMLQGSGMEQM GMNMQDALSGLMPKKKKRRKMTVREARKVLTNEEASKLIDMDEVGQEAVQRAEESGII FIDEIDKIAKNGGASSSADVSREGVQRDILPIVEGSTVVTKYGSVKTDHVLFIAAGAF HMAKPSDLIPELQGRFPIRVELNKLTVDDFVRILVEPDNALLKQYQALLQTEGISLEF SDEAIHKIAEVAYHVNQDTDNIGARRLHTILERLLEDLSFEAPDVTMEKITITPQYVE EKLGTIAKNKDLSQFIL*" /label="clpY CDS" gene 1601004..1602407 /gene="clpY" /locus_tag="BSU_16160" /old_locus_tag="BSU16160" /label="clpY gene" CDS 1602447..1603226 /gene="codY" /locus_tag="BSU_16170" /old_locus_tag="BSU16170" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9515911, 10094682, 10231480, 10803944, 10809682, 16488888, 17993518, 21856856, 24843172, 26473603, 27596595, 28011634" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9515911, 10094682, 10231480, 10803944, 10809682, 16488888, 17993518, 21856856, 24843172, 26473603, 27596595, 28011634; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator, GTP and BCAA-dependent" /protein_id="NP_389499.1" /db_xref="EnsemblGenomes-Gn:BSU16170" /db_xref="EnsemblGenomes-Tr:CAB13490" /db_xref="GOA:P39779" /db_xref="InterPro:IPR010312" /db_xref="InterPro:IPR013198" /db_xref="InterPro:IPR014154" /db_xref="InterPro:IPR029016" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2B0L" /db_xref="PDB:2B18" /db_xref="PDB:2GX5" /db_xref="PDB:2HGV" /db_xref="PDB:5LNH" /db_xref="PDB:5LOE" /db_xref="PDB:5LOJ" /db_xref="PDB:5LOO" /db_xref="SubtiList:BG10968" /db_xref="UniProtKB/Swiss-Prot:P39779" /translation="MALLQKTRIINSMLQAAAGKPVNFKEMAETLRDVIDSNIFVVSR RGKLLGYSINQQIENDRMKKMLEDRQFPEEYTKNLFNVPETSSNLDINSEYTAFPVEN RDLFQAGLTTIVPIIGGGERLGTLILSRLQDQFNDDDLILAEYGATVVGMEILREKAE EIEEEARSKAVVQMAISSLSYSELEAIEHIFEELDGNEGLLVASKIADRVGITRSVIV NALRKLESAGVIESRSLGMKGTYIKVLNNKFLIELENLKSH*" /label="codY CDS" gene 1602447..1603226 /gene="codY" /locus_tag="BSU_16170" /old_locus_tag="BSU16170" /label="codY gene" downshifts 1603201 /Source="Nicolas_upshifts" /id="D893" /incds=0 /nref=6 /ntot=130 /MaxReadThrough="5.35492" /MaxDrop="5.90286" /score="-6.99307778" /energy="-4.2" /TU="U1321,U1322" /idTUdmin="U1320" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 1603245 /Source="Nicolas_upshifts" /id="D894" /incds=0 /nref=1 /ntot=104 /MaxReadThrough="4.95658" /MaxDrop="4.85551" /score="-6.99307778" /energy="-4.2" /TU="U1321,U1322" /idTUdmin="U1320" /TUdmin=44 /isTUend="FALSE" /label="downshifts" promotor_-35 1603346..1603353 /Source="Nicolas_upshift_promotors" /id="U1323" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2824 /SigmaFactorBS="gtaataattttaataaattttgcatttttCTTCAAAAagttt caaaaatGCCGAAAAGAAAGGAGAAAaaacagaaattctgctattttcaggcttatat c" /listShort="S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL" /listLong="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1603366..1603384 /Source="Nicolas_upshift_promotors" /id="U1323" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2824 /SigmaFactorBS="gtaataattttaataaattttgcatttttCTTCAAAAagttt caaaaatGCCGAAAAGAAAGGAGAAAaaacagaaattctgctattttcaggcttatat c" /listShort="S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL" /listLong="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" S_feature 1603377..1603530 /Source="Nicolas_S_feature" /locus_tag="new_1691049_1691202" /HighExp="C30, GM 90, GM 25, Cold, GM 15, GM 10, MG 150, GM-0.2, LBGstat, GM-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA, SigA" /TUshortPSig="1, 0.994, 0.998" /TUlongSig="SigA, SigA, SigD, SigA, SigA" /TUlongPSig="1, 0.999, 1, 1, 1" /label="S584" upshifts 1603377 /Source="Nicolas_upshifts" /id="U1323" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2824 /SigmaFactorBS="gtaataattttaataaattttgcatttttCTTCAAAAagttt caaaaatGCCGAAAAGAAAGGAGAAAaaacagaaattctgctattttcaggcttatat c" /listShort="S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL" /listLong="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" promotor_-35 1603505..1603512 /Source="Nicolas_upshift_promotors" /id="U1324" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.748251748251748" /psig="0.998001998001998" /xcortree=2791 /SigmaFactorBS="gataattgtgaggacatttttttacacgaacttCATAGACTt tatgcctgttattTCTTACAATAAGCATATAGTtttacaattctcgacaaggatattg a" /listShort="flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1603527..1603546 /Source="Nicolas_upshift_promotors" /id="U1324" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.748251748251748" /psig="0.998001998001998" /xcortree=2791 /SigmaFactorBS="gataattgtgaggacatttttttacacgaacttCATAGACTt tatgcctgttattTCTTACAATAAGCATATAGTtttacaattctcgacaaggatattg a" /listShort="flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1603532 /Source="Nicolas_upshifts" /id="U1324" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.748251748251748" /psig="0.998001998001998" /xcortree=2791 /SigmaFactorBS="gataattgtgaggacatttttttacacgaacttCATAGACTt tatgcctgttattTCTTACAATAAGCATATAGTtttacaattctcgacaaggatattg a" /listShort="flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" CDS 1603606..1603995 /gene="flgB" /locus_tag="BSU_16180" /old_locus_tag="BSU16180" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1905667, 2129540, 2181149, 9657996, 17850253, 25843804; Product type s: structure" /codon_start=1 /transl_table=11 /product="flagellar component of cell-proximal portion of basal-body rod" /protein_id="NP_389500.1" /db_xref="EnsemblGenomes-Gn:BSU16180" /db_xref="EnsemblGenomes-Tr:CAB13491" /db_xref="GOA:P24500" /db_xref="InterPro:IPR001444" /db_xref="InterPro:IPR006300" /db_xref="InterPro:IPR019776" /db_xref="SubtiList:BG10237" /db_xref="UniProtKB/Swiss-Prot:P24500" /translation="MSLFSGTIQNLENALSRADIKQKVITNNIANIDTPNYKAKKVSF QNLLDQESSRLEAIKTDYRHVDFSDTDSNYSIVASGDTSYQQNGNNVDVDKEMTELAQ NQINYQALVERMNGKFNSLKTVLTGGK*" /label="flgB CDS" gene 1603606..1603995 /gene="flgB" /locus_tag="BSU_16180" /old_locus_tag="BSU16180" /label="flgB gene" CDS 1603995..1604447 /gene="flgC" /locus_tag="BSU_16190" /old_locus_tag="BSU16190" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1905667, 2129540, 2181149, 9657996; Product type s: structure" /codon_start=1 /transl_table=11 /product="flagellar component of cell-proximal portion of basal-body rod" /protein_id="NP_389501.1" /db_xref="EnsemblGenomes-Gn:BSU16190" /db_xref="EnsemblGenomes-Tr:CAB13492" /db_xref="GOA:P24501" /db_xref="InterPro:IPR001444" /db_xref="InterPro:IPR006299" /db_xref="InterPro:IPR010930" /db_xref="InterPro:IPR019776" /db_xref="SubtiList:BG10238" /db_xref="UniProtKB/Swiss-Prot:P24501" /translation="MTAFHSLNVSASALTAQRVRMDVVSSNLANMDTTRAKQVNGEWV PYRRKMVSLQSKGESFSSILNSQMSGSGNAGNGVKVSKITEDDSDFNLVYDPTDPDAN AEGYVQKPNVDPLKEMVDLVSSTRSYEANVTAMNATKGMLMKALEIGK*" /label="flgC CDS" gene 1603995..1604447 /gene="flgC" /locus_tag="BSU_16190" /old_locus_tag="BSU16190" /label="flgC gene" CDS 1604458..1604778 /gene="fliE" /locus_tag="BSU_16200" /old_locus_tag="BSU16200" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11133968, 1551848, 1905667, 2544561, 9161424, 11133968, 15136044; Product type s: structure" /codon_start=1 /transl_table=11 /product="flagellar basal body protein" /protein_id="NP_389502.1" /db_xref="EnsemblGenomes-Gn:BSU16200" /db_xref="EnsemblGenomes-Tr:CAB13493" /db_xref="GOA:P24502" /db_xref="InterPro:IPR001624" /db_xref="SubtiList:BG10239" /db_xref="UniProtKB/Swiss-Prot:P24502" /translation="MINAISPFQVQNTQNTQNATNQVNNSQKTDSSNQTSFSELLKNS ISSLNESQVASDNMTNALAAGKDVNLDEVMIAAQKASISLTAATEFRNKAVEAYQEIM RMQM*" /label="fliE CDS" gene 1604458..1604778 /gene="fliE" /locus_tag="BSU_16200" /old_locus_tag="BSU16200" /label="fliE gene" downshifts complement(1604773) /Source="Nicolas_upshifts" /id="D895" /incds=0 /nref=1 /ntot=83 /MaxReadThrough="1.38909" /MaxDrop="2.66249" /score="0.0645368779" /energy="-7.4" /TU="NA" /idTUdmin="U1325" /TUdmin=2684 /isTUend="FALSE" /label="downshifts" CDS 1604824..1606434 /gene="fliF" /locus_tag="BSU_16210" /old_locus_tag="BSU16210" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1551848, 1905667, 2544561, 9161424, 11133968, 22670715, 24970213, 28089452; Product type s: structure" /codon_start=1 /transl_table=11 /product="flagellar basal-body M-ring protein" /protein_id="NP_389503.1" /db_xref="EnsemblGenomes-Gn:BSU16210" /db_xref="EnsemblGenomes-Tr:CAB13494" /db_xref="GOA:P23447" /db_xref="InterPro:IPR000067" /db_xref="InterPro:IPR006182" /db_xref="InterPro:IPR013556" /db_xref="InterPro:IPR021157" /db_xref="SubtiList:BG10240" /db_xref="UniProtKB/Swiss-Prot:P23447" /translation="MNRTLMQMKNKTSEFWKNRSKLQKILMVSALAAIIIIGIIISVF ASNSKMAPLYKDLSAEEAGQIKEELDAKKVPNELSNGGTVISVPEDQVDSLKVQMAAE GLPKTGSIDYSFFGQNAGFGLTDNEFDMVKVKATQTELSNLINEMDGIKNSKVMINLP KDAVFVGEEQSAASASIVLQIQPGYTLDQSQINGLYHLVSKSVPNLKEDNIVIMDQNS TYYDKSDSDAGSYADSYSSQQGIKSQVEKDIQKHVQSLLGTMMGQDKVVVSVTADIDF TKENRTEDIVEPVDKENMEGIAVSAEKVSETYQGDGAANGGTAGTGEEDVTNYKADGE NTESGNYEKNSNKINYEVNRIHKEIAESPYKVRDLGIQVMVEPPDAKNTASLSTERQD DIQKILSTVVRTSLDKDETQNQNLSDADINNKIVVSVQPFDGKVNLDTNTEESSGIPL WAYIVGGVLIAAIIVLIIMLIRKKRAQEDEFEEYEYEVPQEPINLPDINEEENETAES VRRKQLEKMAKDKPEDFAKLLRSWLAED*" /label="fliF CDS" gene 1604824..1606434 /gene="fliF" /locus_tag="BSU_16210" /old_locus_tag="BSU16210" /label="fliF gene" CDS 1606447..1607463 /gene="fliG" /locus_tag="BSU_16220" /old_locus_tag="BSU16220" /function="16.5: Explore" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1551848, 1905667, 2544561, 9161424, 10440379, 11133968, 28089452; Product type s : structure" /codon_start=1 /transl_table=11 /product="flagellar motor switching and energizing component" /protein_id="NP_389504.1" /db_xref="EnsemblGenomes-Gn:BSU16220" /db_xref="EnsemblGenomes-Tr:CAB13495" /db_xref="GOA:P23448" /db_xref="InterPro:IPR000090" /db_xref="InterPro:IPR011002" /db_xref="InterPro:IPR023087" /db_xref="InterPro:IPR028263" /db_xref="InterPro:IPR032779" /db_xref="SubtiList:BG10241" /db_xref="UniProtKB/Swiss-Prot:P23448" /translation="MARRDQDKLTGKQKAAILMISLGLDVSASVYKHLTDEEIERLTL EISGVRSVDHQKKDEIIEEFHNIAIAQDYISQGGLSYARQVLEKALGEDKAENILNRL TSSLQVKPFDFARKAEPEQILNFIQQEHPQTMALILSYLDPVQAGQILSELNPEVQAE VARRIAVMDRTSPEIINEVERILEQKLSSAFTQDYTQTGGIEAVVEVLNGVDRGTEKT ILDSLEIQDPDLAEEIKKRMFVFEDIVTLDNRAIQRVIRDVENDDLLLSLKVASEEVK EIVFNNMSQRMVETFKEEMEFMGPVRLKDVEEAQSRIVSIVRKLEEAGEIVIARGGGD DIIV*" /label="fliG CDS" gene 1606447..1607463 /gene="fliG" /locus_tag="BSU_16220" /old_locus_tag="BSU16220" /label="fliG gene" S_feature 1607464..1607581 /Source="Nicolas_S_feature" /locus_tag="new_1695136_1695253" /HighExp="Lbstat, C90, M0t90, M40t90, Lbtran, C30, LPhT, GM 90, M40t45, GM-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD, SigA" /TUshortPSig="0.998, 1, 0.998" /TUlongSig="SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.994, 1, 0.999, 1, 1, 1" /label="S585" promotor_no_box complement(1607527..1607627) /Source="Nicolas_upshift_promotors" /id="U1325" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.937062937062937" /psig="0.00999000999001" /xcortree=81 /SigmaFactorBS="ttgcctgctcagaaatccggtcagcttcctctttcactcggg ccataagcgcctccgggttctcttcagcctgcaaaaggtgagaatgatcaatacgcac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1607567) /Source="Nicolas_upshifts" /id="U1325" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.937062937062937" /psig="0.00999000999001" /xcortree=81 /SigmaFactorBS="ttgcctgctcagaaatccggtcagcttcctctttcactcggg ccataagcgcctccgggttctcttcagcctgcaaaaggtgagaatgatcaatacgcac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1607582..1608208 /gene="fliH" /locus_tag="BSU_16230" /old_locus_tag="BSU16230" /function="16.6: Maintain" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1828465, 12217691, 16522800, 17002279, 26916245; Product type f: factor" /codon_start=1 /transl_table=11 /product="flagellar export apparatus subunit of cytoplasmic ATPase" /protein_id="NP_389505.2" /db_xref="EnsemblGenomes-Gn:BSU16230" /db_xref="EnsemblGenomes-Tr:CAB13496" /db_xref="GOA:P23449" /db_xref="InterPro:IPR018035" /db_xref="InterPro:IPR022524" /db_xref="SubtiList:BG10242" /db_xref="UniProtKB/Swiss-Prot:P23449" /translation="MARVKEEADRISEQANSHIENIRRQIEQEKNDWAAEKQKLIEEA KAEGFEQGVALGKAEAMKQYAELIGQANSITEMSRKAVEDKLEDANEEIVELAVALAK KVWQQKSDDKEAFLLLVQQVINEVKEYDDISIYVDPYYYETIFQQKDEIQQLLYKECR LGIYADEKAQKGTCYIETPFGRVDASVDTQLMQLKDKLLTALEAGAAE*" /label="fliH CDS" gene 1607582..1608208 /gene="fliH" /locus_tag="BSU_16230" /old_locus_tag="BSU16230" /label="fliH gene" CDS 1608205..1609521 /gene="fliI" /locus_tag="BSU_16240" /old_locus_tag="BSU16240" /EC_number="3.6.3.14" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12787361, 16113269, 16780875, 17002279, 26916245; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="flagellar-specific ATPase subunit of export apparatus" /protein_id="NP_389506.2" /db_xref="EnsemblGenomes-Gn:BSU16240" /db_xref="EnsemblGenomes-Tr:CAB13497" /db_xref="GOA:P23445" /db_xref="InterPro:IPR000194" /db_xref="InterPro:IPR000225" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004100" /db_xref="InterPro:IPR005714" /db_xref="InterPro:IPR020003" /db_xref="InterPro:IPR022425" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032463" /db_xref="SubtiList:BG10243" /db_xref="UniProtKB/Swiss-Prot:P23445" /translation="MKTQSLIDCIEMTDSYKRYGKVKRVIGLMIESKGPASSIGDLCL IYAKGQSGKVIKAEVVGFQEENILLMPYLEAASIAPGSIVEATGESLRVKVGTGLIGQ VIDAFGEPLDGKLLPKGLSPVSTEQSPPNPMKRPPIREKMGVGVRSIDSLLTVGKGQR IGIFAGSGVGKSTLMGMIAKQTEADLNVIALVGERGREVREFIEKDLGKEGLKRSIVV VATSDQPALMRLKAAYTATAIAEYFRDKGQNVMFMMDSVTRVAMAQREIGLAAGEPPT TKGYTPSVFAILPRLLERTGANEHGTITAFYTVLVDGDDMNEPIADTVRGILDGHIVL DRALANKGQFPAVNVLKSISRVMSNISTKQHLDAANKFRELLSTYQNSEDLINIGAYK RGSSREIDEAIQFYPQLIQFLKQGTDEPALLEESIAALTSLTGNEE*" /label="fliI CDS" gene 1608205..1609521 /gene="fliI" /locus_tag="BSU_16240" /old_locus_tag="BSU16240" /label="fliI gene" CDS 1609524..1609967 /gene="fliJ" /locus_tag="BSU_16250" /old_locus_tag="BSU16250" /function="16.13: Shape" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17088562, 26916245, 26984495, 27647891; Product type f: factor" /codon_start=1 /transl_table=11 /product="flagellar synthesis rod subunit of export ATPase" /protein_id="NP_389507.1" /db_xref="EnsemblGenomes-Gn:BSU16250" /db_xref="EnsemblGenomes-Tr:CAB13498" /db_xref="GOA:P20487" /db_xref="InterPro:IPR012823" /db_xref="SubtiList:BG10245" /db_xref="UniProtKB/Swiss-Prot:P20487" /translation="MAYQFRFQKLLELKENEKDQSLSEYQQSVSEFENVAEKLYENMS KKELLEQNKEKKLKSGMSVQEMRHYQQFVSNLDNTIYHYQKLVIMKRNQMNQKQEILT EKNIEVKKFEKMREKQFKMFALEDKAAEMKEMDDISIKQFMIQGH*" /label="fliJ CDS" gene 1609524..1609967 /gene="fliJ" /locus_tag="BSU_16250" /old_locus_tag="BSU16250" /label="fliJ gene" CDS 1609979..1610593 /gene="ylxF" /locus_tag="BSU_16260" /old_locus_tag="BSU16260" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17586671, 22307758; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative kinesin-like protein" /protein_id="NP_389508.2" /db_xref="EnsemblGenomes-Gn:BSU16260" /db_xref="EnsemblGenomes-Tr:CAB13499" /db_xref="GOA:P23454" /db_xref="InterPro:IPR006668" /db_xref="InterPro:IPR011002" /db_xref="SubtiList:BG10246" /db_xref="UniProtKB/Swiss-Prot:P23454" /translation="MSGKKKESGKFRSVLLIIILPLMFLLIAGGIVLWAAGINVLKPI QDAAAKTPVLKELVPETENKKGAASSKDSSNTAALEKTIKDQKSEISILNKDLETSKS EIDRLNQKIRSLEKTAEDQKKSSEDHTEGSADSKASSENDKVISVYKSMDSGKAAKII AQLKEQEALKILNGLSKKQLADILAKMTPEQAATYTEKIAASQE*" /label="ylxF CDS" gene 1609979..1610593 /gene="ylxF" /locus_tag="BSU_16260" /old_locus_tag="BSU16260" /label="ylxF gene" CDS 1610606..1612069 /gene="fliK" /locus_tag="BSU_16270" /old_locus_tag="BSU16270" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16630628, 16949608, 28557186; Product type f: factor" /codon_start=1 /transl_table=11 /product="flagellar hook-length control protein (ruler)" /protein_id="NP_389509.2" /db_xref="EnsemblGenomes-Gn:BSU16270" /db_xref="EnsemblGenomes-Tr:CAB13500" /db_xref="GOA:P23451" /db_xref="InterPro:IPR001635" /db_xref="InterPro:IPR021136" /db_xref="SubtiList:BG10247" /db_xref="UniProtKB/Swiss-Prot:P23451" /translation="MKLLELAGPLLQTTTGSAAKNMKSSQGVFQNWLMSEAGLKELSE QGKGTPNSEDQLLADALKKIGEWLNASPEDQDKQNADLLQTLSKLTGKQLDANALQML QNLLQAVESKMSGGTDQLLTETEKIFSEAKTALSANDSASDINGALKSDKEQSNQENE VSEPAKELIYIQMFISQLVEGNKLTDLGNGNEAHAIYQNGDQFLSALEKKGVSQQLIQ DLKQQIFTKAESSSKLYSMTASELKSFQSLMDQMSMLPQKGTKEWSLAESQLKAFLLS KSSESSQDFGKSVLTPLSQSSSSKNASDVSGSIQPVDSKSGLQMLFSGYRGIGGVQTL DLQQMSSDIPNAETKTVADQVINAWKQMKYTPFGRSTGSFTIRLNPEHLGFVTIKLTN ENGMFQSKIIASSQSAKELLEQHLPQLKQSLPNMAVQIDRFTLPVQSGDQPIYGQLAD EQKQQQEGQRQQRQKKQSNDFGDLLDEVSMVEMEEEE*" /label="fliK CDS" gene 1610606..1612069 /gene="fliK" /locus_tag="BSU_16270" /old_locus_tag="BSU16270" /label="fliK gene" CDS 1612066..1612488 /gene="flgD" /locus_tag="BSU_16280" /old_locus_tag="BSU16280" /function="16.13: Shape" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8157595, 14563871, 24748615; Product type f: factor" /codon_start=1 /transl_table=11 /product="flagellar hook capping protein" /protein_id="NP_389510.1" /db_xref="EnsemblGenomes-Gn:BSU16280" /db_xref="EnsemblGenomes-Tr:CAB13501" /db_xref="GOA:P23455" /db_xref="InterPro:IPR005648" /db_xref="SubtiList:BG10248" /db_xref="UniProtKB/Swiss-Prot:P23455" /translation="MTSISSEYKLPEKTNTVSTNNSSLGKDEFLKILMTQVQNQDPLN PIDDKEFISQMATFSSLEQMMNLNTTMTQFVENQDPFTTYVDWMGKEVSWTDGKSATD KTGTVSSVKHFKGNYYLVLDDGTEISPANVMSVGQSSK*" /label="flgD CDS" gene 1612066..1612488 /gene="flgD" /locus_tag="BSU_16280" /old_locus_tag="BSU16280" /label="flgD gene" CDS 1612510..1613304 /gene="flgE" /locus_tag="BSU_16290" /old_locus_tag="BSU16290" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15502333, 15510139, 27759043, 28120828, 28429800; Product type f: factor" /codon_start=1 /transl_table=11 /product="flagellar hook protein" /protein_id="NP_389511.2" /db_xref="EnsemblGenomes-Gn:BSU16290" /db_xref="EnsemblGenomes-Tr:CAB13502" /db_xref="GOA:P23446" /db_xref="InterPro:IPR001444" /db_xref="InterPro:IPR010930" /db_xref="InterPro:IPR012836" /db_xref="InterPro:IPR019776" /db_xref="InterPro:IPR020013" /db_xref="SubtiList:BG10249" /db_xref="UniProtKB/Swiss-Prot:P23446" /translation="MLRSLYSGISGMKNFQTKLDVIGNNIANVNTVGFKKSRVTFKDM VSQTIAGGSAAGATIGGTNSKQIGLGSSSGTIDTIHSTSATQSTGRTLDLAIDGDGYF RIDTGDGTAYTRAGNFYLDNTGTLVTGDGYHVLNMNGGTIKIPTDAQSFSIGSDGKVS IVDAEGKTQDGGQIGIVTFANSDGLDKIGSNLYRESLNSGTASAANQPGDGGTGALKS GFLEMSNVDLTDEFTEMIVAQRGFQSNSKIITTSDEILQELVNLKR*" /label="flgE CDS" gene 1612510..1613304 /gene="flgE" /locus_tag="BSU_16290" /old_locus_tag="BSU16290" /label="flgE gene" CDS 1613344..1613559 /gene="swrD" /locus_tag="BSU_16299" /old_locus_tag="BSU16299" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9168127, 29061663" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9168127, 29061663; Product type f: factor" /codon_start=1 /transl_table=11 /product="flagellar power transducer required for swarming" /protein_id="YP_003097728.1" /db_xref="EnsemblGenomes-Gn:BSU16299" /db_xref="EnsemblGenomes-Tr:CAX52619" /db_xref="InterPro:IPR009384" /db_xref="UniProtKB/Swiss-Prot:C0H412" /translation="MIKVTRLNGQPFTLNALFIEQIECFPDTTITLSNGKKFVVKEDE EAVLEKIAAFYRKIQIFAMDQGIEEPE*" /label="swrD CDS" gene 1613344..1613559 /gene="swrD" /locus_tag="BSU_16299" /old_locus_tag="BSU16299" /label="swrD gene" CDS 1613556..1613978 /gene="fliL" /locus_tag="BSU_16300" /old_locus_tag="BSU16300" /function="16.5: Explore" /function="16.12: Sense" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10439416, 12787361, 16166542, 23264580, 25714720, 28717192; Product type f : factor" /codon_start=1 /transl_table=11 /product="flagellar basal-body (stator) associated protein" /protein_id="NP_389512.1" /db_xref="EnsemblGenomes-Gn:BSU16300" /db_xref="EnsemblGenomes-Tr:CAB13503" /db_xref="GOA:P23452" /db_xref="InterPro:IPR005503" /db_xref="SubtiList:BG10250" /db_xref="UniProtKB/Swiss-Prot:P23452" /translation="MKKKLMIILLIILIVIGALGAAAYFVLGGKSEKSEAKKSIDEIV ASSVDVEEITTNLKSDNIIRLAIKLETDSDKSKEELEKRDFQVKDAVISLLADTNADQ IEGDKGKETFKKELKDKINSYLQEGKVEKVYITSFNLQ*" /label="fliL CDS" gene 1613556..1613978 /gene="fliL" /locus_tag="BSU_16300" /old_locus_tag="BSU16300" /label="fliL gene" CDS 1614012..1615010 /gene="fliM" /locus_tag="BSU_16310" /old_locus_tag="BSU16310" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7787061, 16547037, 16796690, 16882724, 17015643, 17050923, 22720735, 28625846; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="flagellar motor switching and energizing component" /protein_id="NP_389513.1" /db_xref="EnsemblGenomes-Gn:BSU16310" /db_xref="EnsemblGenomes-Tr:CAB13504" /db_xref="GOA:P23453" /db_xref="InterPro:IPR001543" /db_xref="InterPro:IPR001689" /db_xref="InterPro:IPR028976" /db_xref="InterPro:IPR036429" /db_xref="SubtiList:BG10251" /db_xref="UniProtKB/Swiss-Prot:P23453" /translation="MSGEVLSQNEIDALLSAISTGEMDAEELKKEEKEKKVKVYDFKR ALRFSKDQIRSLTRIHDNFARLLTTHFSAQLRTYIHISVSSVDQVPYEEFIRSIPNMT ILNLFDVHPMEGRIMMEVNPTIAYTMMDRVMGGIGISHNKVDSLTEIETKIISNLFEN ALGNYKEAWQSIADIEPEMTEFEVNPQFVQMVSPNETVVVISLNTQIGEISGVINLCI PHIVLEPLIPKLSVHYWMQSDRNEPKPEETKSLEKRIMTAQIPVVAELGTSELTIEEF LSLEVGDCITLDKSVTDPLTVLVGDKPKFLGQAGRVNRKQAVQILDHDIRGEQDGE*" /label="fliM CDS" gene 1614012..1615010 /gene="fliM" /locus_tag="BSU_16310" /old_locus_tag="BSU16310" /label="fliM gene" CDS 1615000..1616136 /gene="fliY" /locus_tag="BSU_16320" /old_locus_tag="BSU16320" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12920116, 16547037, 16796690, 16882724, 17015643, 17050923, 23226535, 23532838, 26195616" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12920116, 16547037, 16796690, 16882724, 17015643, 17050923, 23226535, 23532838, 26195616; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="flagellar motor switching and energizing phosphatase" /protein_id="NP_389514.1" /db_xref="EnsemblGenomes-Gn:BSU16320" /db_xref="EnsemblGenomes-Tr:CAB13505" /db_xref="GOA:P24073" /db_xref="InterPro:IPR001172" /db_xref="InterPro:IPR001543" /db_xref="InterPro:IPR007597" /db_xref="InterPro:IPR012826" /db_xref="InterPro:IPR028976" /db_xref="InterPro:IPR036429" /db_xref="SubtiList:BG10252" /db_xref="UniProtKB/Swiss-Prot:P24073" /translation="MENNRLSQDEIDALLNGTGSTLDEPEIPEVDDLSEMERDAIGEI GNISFGSSATALSTLLNQKVDITTPSVTVIPRSKISDAFPEPYVAIEVNYTEGFSGSN LLVVEQSDAAIIADLMIGGDGKGADPSLGEIHLSAVQEAMNQMMGSAATSMSTVFSKK IDISPPRVELLDVTEEKGTDRIPDDEMLVKVSFNLKVGELIDSSIMQLYPLTFAKDLI SSLMNSESAEEEETVQPEVTYEQPKEPVTPEPRIEPKQQQQPPKRQGTAKKAAPVQVS PVEFSAFDPNEAVQAPIHNLDMLLDIPLSITVELGRTKRSVKEILELSAGSIIELDKL AGEPVDILVNQRIVAKGEVVVIEENFGVRVTDILSQAERINNLK*" /label="fliY CDS" gene 1615000..1616136 /gene="fliY" /locus_tag="BSU_16320" /old_locus_tag="BSU16320" /label="fliY gene" CDS 1616162..1616524 /gene="cheY" /locus_tag="BSU_16330" /old_locus_tag="BSU16330" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10196193, 12864845, 12920116, 14749334, 23226535, 28542702" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10196193, 12864845, 12920116, 14749334, 23226535, 28542702; Product type r : regulator" /codon_start=1 /transl_table=11 /product="regulator of chemotaxis and motility" /protein_id="NP_389515.1" /db_xref="EnsemblGenomes-Gn:BSU16330" /db_xref="EnsemblGenomes-Tr:CAB13506" /db_xref="GOA:P24072" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="SubtiList:BG10258" /db_xref="UniProtKB/Swiss-Prot:P24072" /translation="MAHRILIVDDAAFMRMMIKDILVKNGFEVVAEAENGAQAVEKYK EHSPDLVTMDITMPEMDGITALKEIKQIDAQARIIMCSAMGQQSMVIDAIQAGAKDFI VKPFQADRVLEAINKTLN*" /label="cheY CDS" gene 1616162..1616524 /gene="cheY" /locus_tag="BSU_16330" /old_locus_tag="BSU16330" /label="cheY gene" CDS 1616539..1617198 /gene="fliZ" /locus_tag="BSU_16340" /old_locus_tag="BSU16340" /function="16.3: Control" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10791024, 1597417, 16513753, 24204316; Product type r: regulator" /codon_start=1 /transl_table=11 /product="flagellar regulatory protein" /protein_id="NP_389516.1" /db_xref="EnsemblGenomes-Gn:BSU16340" /db_xref="EnsemblGenomes-Tr:CAB13507" /db_xref="GOA:P35536" /db_xref="InterPro:IPR022781" /db_xref="SubtiList:BG10259" /db_xref="UniProtKB/Swiss-Prot:P35536" /translation="MKKSQYFIVFICFFVLFSVHPIAAAAADSDNSTVNEWFQKKDEK TADQSEQKKEKTTKTADETEGAAAPSVSAFDFVKMIFALLFVIVLIYGLVKLMNKRNR LLKPFQYVENIGGTSVGQNRSIQLIKVGKSVLVVGVGETIQLLKEIEDEKEIEVILSQ HEEAMSSKIEWQKFVKPLKSSEHQPQQKLPSFSKALKEQLEELKQNRSEGKKKGPRHH E*" /label="fliZ CDS" gene 1616539..1617198 /gene="fliZ" /locus_tag="BSU_16340" /old_locus_tag="BSU16340" /label="fliZ gene" CDS 1617191..1617856 /gene="fliP" /locus_tag="BSU_16350" /old_locus_tag="BSU16350" /function="16.3: Control" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15516571, 15849754, 16850406, 22720735, 26244495, 27855178, 28559296; Product type t: transporter" /codon_start=1 /transl_table=11 /product="component of the flagellar export machinery" /protein_id="NP_389517.1" /db_xref="EnsemblGenomes-Gn:BSU16350" /db_xref="EnsemblGenomes-Tr:CAB13508" /db_xref="GOA:P35528" /db_xref="InterPro:IPR005837" /db_xref="InterPro:IPR005838" /db_xref="SubtiList:BG10260" /db_xref="UniProtKB/Swiss-Prot:P35528" /translation="MNEFINIFSSSDPENVSSTVKLLLLLTVFSVAPGILILMTCFTR IVIVLSFVRTSLATQSMPPNQVLIGLALFLTFFIMAPTFSEINKEALTPLMDNKISLD EAYTKAEEPIKEFMSKHTRQKDLALFMNYAKMDKPESLKDIPLTTMVPAFAISELKTA FQIGFMIFIPFLIIDMVVASVLMSMGMMMLPPVMISLPFKILLFVLVDGWYLIVKSLL QSF*" /label="fliP CDS" gene 1617191..1617856 /gene="fliP" /locus_tag="BSU_16350" /old_locus_tag="BSU16350" /label="fliP gene" CDS 1617871..1618140 /gene="fliQ" /locus_tag="BSU_16360" /old_locus_tag="BSU16360" /function="16.5: Explore" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10234819, 15516571, 27855178; Product type t: transporter" /codon_start=1 /transl_table=11 /product="component of the flagellar export machinery" /protein_id="NP_389518.1" /db_xref="EnsemblGenomes-Gn:BSU16360" /db_xref="EnsemblGenomes-Tr:CAB13509" /db_xref="GOA:P35535" /db_xref="InterPro:IPR002191" /db_xref="InterPro:IPR006305" /db_xref="SubtiList:BG10261" /db_xref="UniProtKB/Swiss-Prot:P35535" /translation="MSSEFVISMAEKAVYVTLMISGPLLAIALLVGLIVSIFQATTQI QEQTLAFIPKIVAVLLALIFFGPWMLSTILSFTTELFSNLNRFAG*" /label="fliQ CDS" gene 1617871..1618140 /gene="fliQ" /locus_tag="BSU_16360" /old_locus_tag="BSU16360" /label="fliQ gene" CDS 1618148..1618927 /gene="fliR" /locus_tag="BSU_16370" /old_locus_tag="BSU16370" /function="16.5: Explore" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15060055, 15516571, 15849754, 16850406, 28771474; Product type t : transporter" /codon_start=1 /transl_table=11 /product="component of the flagellar export machinery" /protein_id="NP_389519.2" /db_xref="EnsemblGenomes-Gn:BSU16370" /db_xref="EnsemblGenomes-Tr:CAB13510" /db_xref="GOA:P35537" /db_xref="InterPro:IPR002010" /db_xref="InterPro:IPR006303" /db_xref="SubtiList:BG10262" /db_xref="UniProtKB/Swiss-Prot:P35537" /translation="MNSIIDLFPAFLLVFIRISAFFVTIPLFGHRNVPAVHRIGFAFF LAVICFSTIDKPPSLEIDEHYMLLAFKEALVGLCLGLIAYMMIAAVQIAGSFIDFQMG FSIANVIDPQTGAQSPLIGQFIYTMALLFMLSVNAHHLLLDGIYYSFQYISVDQAFPN FGDEKFAYFIAKSFNAMFIIAFQMSAPVVASLFLVDLALGIVARTVPQLNVFVVGLPL KIAVSFIMLIVCMSVIFVVVRNVFSLTIETMRNLLALVGVS*" /label="fliR CDS" gene 1618148..1618927 /gene="fliR" /locus_tag="BSU_16370" /old_locus_tag="BSU16370" /label="fliR gene" CDS 1618927..1620009 /gene="flhB" /locus_tag="BSU_16380" /old_locus_tag="BSU16380" /function="16.1: Circulate" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10234819, 16949608, 17050924, 17067800, 28557186, 28771466; Product type t : transporter" /codon_start=1 /transl_table=11 /product="component of the flagellar export machinery" /protein_id="NP_389520.1" /db_xref="EnsemblGenomes-Gn:BSU16380" /db_xref="EnsemblGenomes-Tr:CAB13511" /db_xref="GOA:P35538" /db_xref="InterPro:IPR006135" /db_xref="InterPro:IPR006136" /db_xref="InterPro:IPR029025" /db_xref="SubtiList:BG10543" /db_xref="UniProtKB/Swiss-Prot:P35538" /translation="MKLRVDLQFFAGEKTEKATPKKRKDTRKKGQVAKSSDVNTAVSL LVIFLSLIAIGPYMRDRLLSFIETFYTESLTMKLSESNVHTLFVSLLKDMGMILAPIL LVALVAGVVSNYMQVGFLFSAEVIQPKLEKLDPIKGFKRIYSMRAIVELIKSILKIVV VGFAAFAVLWLHYGEILRLPLLTPEEALSFVSKLTLWMGLSGAGALLILAGLDYLYQR FDYEKNIKMSKQDIKDEYKKSEGDPIIKSKIKQRQREMAMRRMMQEVPKADVIITNPT HYAIALKYDEEKMDAPYIVAKGVDHLALKIRKIAKEHDVMMVENRPLARALYDQVEID QAVPEEFFKVLAEILAYVYKTKQKVY*" /label="flhB CDS" gene 1618927..1620009 /gene="flhB" /locus_tag="BSU_16380" /old_locus_tag="BSU16380" /label="flhB gene" CDS 1620042..1622075 /gene="flhA" /locus_tag="BSU_16390" /old_locus_tag="BSU16390" /function="16.1: Circulate" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10234819, 15516571, 20534509, 28771466" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10234819, 15516571, 20534509, 28771466; Product type f: factor" /codon_start=1 /transl_table=11 /product="component of the flagellar export machinery" /protein_id="NP_389521.2" /db_xref="EnsemblGenomes-Gn:BSU16390" /db_xref="EnsemblGenomes-Tr:CAB13512" /db_xref="GOA:P35620" /db_xref="InterPro:IPR001712" /db_xref="InterPro:IPR006301" /db_xref="InterPro:IPR025505" /db_xref="PDB:3MIX" /db_xref="SubtiList:BG10542" /db_xref="UniProtKB/Swiss-Prot:P35620" /translation="MSTRDLSVLISVVLIVAMLVIPFPPWLLSILIIINISLALIVLL TTMNMQEALQFSIFPSLLLLLTLFRLGLNVSTTRSILSHGEGGKVVETFGNFVVGGNV LVGLVVFIILIIIQFIVITKGAERVSEVAARFTLDAMPGKQMSIDADLNAGMITEQEA KHRREKVAREADFYGAMDGASKFVKGDAIAGIIIVMINIIFGIVIGMLQQGMSIQEAA SHFTMLTVGDGIVSQIPALLISTATGIVVTRAASEGNLGHDITGQLFAYPKLLYVAAA TIMLLGIFTPIGILLTGPLAGLLAFGAYTLSKSGKEKEEVDEILEEEAEVDELKSPES VVQLLHIDPIEFEFGYGLIPLADANQGGDLLDRIVMIRRQLALELGLVIPVVRIRDNI ALQPNEYRLKIKGNEVAKGELLLDHYLAMSPTPEDDLIEGIETVEPSFGLPAKWISEA VKDEADMLGYTVVDPASVVSTHITEKIKQHAHELIGRQETKQLIDHLKESYPVLVEEV TPNPLSVGDIQKVLAKLLKEKVSIRNLVTIFETLADYGKLTTDSDLLTEYTRQALAKQ ITAQFAKENEVLKVVTCSGRVEKAIADGVQQTEHGNYLSLEPDISESIVRSVAKEAEQ LSLRQETAILLCSPPVRMYVKQLLERYFPDLPVLSYNELEANVEVQSIGVVDI*" /label="flhA CDS" gene 1620042..1622075 /gene="flhA" /locus_tag="BSU_16390" /old_locus_tag="BSU16390" /label="flhA gene" CDS 1622075..1623175 /gene="flhF" /locus_tag="BSU_16400" /old_locus_tag="BSU16400" /function="16.5: Explore" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1447978, 15317803, 16980502, 17565194, 17699634, 26195616, 27807433; Product type t: transporter" /codon_start=1 /transl_table=11 /product="GTPase involved in the export of flagella and number regulation" /protein_id="NP_389522.1" /db_xref="EnsemblGenomes-Gn:BSU16400" /db_xref="EnsemblGenomes-Tr:CAB13513" /db_xref="GOA:Q01960" /db_xref="InterPro:IPR000897" /db_xref="InterPro:IPR020006" /db_xref="InterPro:IPR027417" /db_xref="PDB:2PX0" /db_xref="PDB:2PX3" /db_xref="PDB:3SYN" /db_xref="SubtiList:BG10544" /db_xref="UniProtKB/Swiss-Prot:Q01960" /translation="MKIKKFTAASMQEAALLIRKELGNEAVILNSKKIKKRKWFGLVN KPAVEVIAVLDQDFLEKKTPQKAAEPKQTLKTPVSSPKIEERTYPPQIPAQQELGDFS AYQSVLPEPLRKAEKLLQETGIKESTKTNTLKKLLRFSVEAGGLTEENVVGKLQEILC DMLPSADKWQEPIHSKYIVLFGSTGAGKTTTLAKLAAISMLEKHKKIAFITTDTYRIA AVEQLKTYAELLQAPLEVCYTKEEFQQAKELFSEYDHVFVDTAGRNFKDPQYIDELKE TIPFESSIQSFLVLSATAKYEDMKHIVKRFSSVPVNQYIFTKIDETTSLGSVFNILAE SKIGVGFMTNGQNVPEDIQTVSPLGFVRMLCR*" /label="flhF CDS" gene 1622075..1623175 /gene="flhF" /locus_tag="BSU_16400" /old_locus_tag="BSU16400" /label="flhF gene" promotor_-10 complement(1623052..1623071) /Source="Nicolas_upshift_promotors" /id="U1326" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1367 /SigmaFactorBS="gcacattctggccgttagtcataaaCCCGACACCTatttttg attctgCCAGTATATTAAATACAGAAcctaaggaagtcgtttcatctattttcgtaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1623059) /Source="Nicolas_upshifts" /id="U1326" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1367 /SigmaFactorBS="gcacattctggccgttagtcataaaCCCGACACCTatttttg attctgCCAGTATATTAAATACAGAAcctaaggaagtcgtttcatctattttcgtaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1623085..1623094) /Source="Nicolas_upshift_promotors" /id="U1326" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1367 /SigmaFactorBS="gcacattctggccgttagtcataaaCCCGACACCTatttttg attctgCCAGTATATTAAATACAGAAcctaaggaagtcgtttcatctattttcgtaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1623166..1624062 /gene="flhG" /locus_tag="BSU_16410" /old_locus_tag="BSU16410" /function="16.5: Explore" /function="16.6: Maintain" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15361076, 25733861, 26411371" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15361076, 25733861, 26411371; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="ATPase affecting flagellar basal body localisation and number" /protein_id="NP_389523.1" /db_xref="EnsemblGenomes-Gn:BSU16410" /db_xref="EnsemblGenomes-Tr:CAB13514" /db_xref="GOA:P40742" /db_xref="InterPro:IPR025501" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR033756" /db_xref="InterPro:IPR033875" /db_xref="PDB:3SYN" /db_xref="SubtiList:BG10254" /db_xref="UniProtKB/Swiss-Prot:P40742" /translation="MQMNRYDQAATLRAKMEKRERVLPMVYSQKAKTLAVISGKGGVG KSNITLNMALALQDKGKKVLLIDLDIGMGNIDILIGNSSSATIIDVLTDRKPLLQSLS VGPKGLRYISGGTGLDVMFQLDQRKWTFFANELSHALSQFDYVLFDMGAGLSKDQLPF ILSAEDILIITTPEPTAIMDAYSAVKHLVLTENKLSMKVAVNRCRDQKEGLDAFARLS RTIHMFLDVQVQFAGSVSDDVIVSKAVVEQVPFFIKSPQAKASRSVRILADALFEREE TRHKEDKQTFIEKLSSFLMRRA*" /label="flhG CDS" gene 1623166..1624062 /gene="flhG" /locus_tag="BSU_16410" /old_locus_tag="BSU16410" /label="flhG gene" CDS 1624064..1625137 /gene="cheB" /locus_tag="BSU_16420" /old_locus_tag="BSU16420" /EC_number="3.1.1.61" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1738311, 10632876, 12123464, 21515776" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1738311, 10632876, 12123464, 21515776; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methyl-accepting chemotaxis proteins (MCP)-glutamate methylesterase" /protein_id="NP_389524.2" /db_xref="EnsemblGenomes-Gn:BSU16420" /db_xref="EnsemblGenomes-Tr:CAB13515" /db_xref="GOA:Q05522" /db_xref="InterPro:IPR000673" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR008248" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR035909" /db_xref="SubtiList:BG10255" /db_xref="UniProtKB/Swiss-Prot:Q05522" /translation="MIRVLVVDDSAFMRKMISDFLTEEKQIEVIGTARNGEEALKKIE LLKPDVITLDVEMPVMNGTDTLRKIIEIYNLPVIMVSSQTEKGKECTINCLEIGAFDF ITKPSGSISLDLYKIKEQLVERVVAAGLSGKRKRPVSQTVRPEPIVRAVVKPELSKPK PGTGRQIVCIGTSTGGPRALQKVIPKLPKDLNAPVVVVQHMPEGFTASLADRLNHLSD IQVKEAKDGEAALNGCVYIAPGGKNISVIKNSEGLQVVLDNHDTPSRHKPSADYLFRS VGKLTDYEKVAVIMTGMGSDGTAGLKDMLTAGNVKAIAESEESCVVYGMPKAAVKAGL IHEIKHVEDIAASITSCVKKERV*" /label="cheB CDS" gene 1624064..1625137 /gene="cheB" /locus_tag="BSU_16420" /old_locus_tag="BSU16420" /label="cheB gene" CDS 1625143..1627161 /gene="cheA" /locus_tag="BSU_16430" /old_locus_tag="BSU16430" /EC_number="2.7.3.-" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:12094812, 12864845, 12920116, 15451661, 16045621, 21515776, 22355139" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12094812, 12864845, 12920116, 15451661, 16045621, 21515776, 22355139; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="chemotactic two-component sensor histidine kinase" /protein_id="NP_389525.2" /db_xref="EnsemblGenomes-Gn:BSU16430" /db_xref="EnsemblGenomes-Tr:CAB13516" /db_xref="GOA:P29072" /db_xref="InterPro:IPR002545" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR004105" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR008207" /db_xref="InterPro:IPR010808" /db_xref="InterPro:IPR035891" /db_xref="InterPro:IPR036061" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036641" /db_xref="InterPro:IPR036890" /db_xref="InterPro:IPR037006" /db_xref="InterPro:IPR037052" /db_xref="SubtiList:BG10256" /db_xref="UniProtKB/Swiss-Prot:P29072" /translation="MDMNQYLDVFIDESKEHLQTCNEKLLLLEKDPTDLQLVHDIFRA AHTLKGMSATMGYTDLAHLTHLLENVLDAIRNGDMEVTSDWLDILFEALDHLETMVQS IIDGGDGKRDISEVSAKLDVNGAHAESAASAEPAEAQSSASDWEYDEFERTVIQEAEE QGFKRYEIKISLNENCMLKAVRVYMVFEKLNEVGEVAKTIPSAEVLETEDFGTDFQVC FLTHQSAEDIEQLINGVSEIEHVEVIQGAPLTSAEKPEESKQEDSPAAAVPAKQEKQK QPAKNDEQAKHSAGGSKTIRVNIDRLDSLMNLFEELVIDRGRLEQIAKELEHNELTET VERMTRISGDLQSIILNMRMVPVETVFNRFPRMIRQLQKELNKKIELSIIGAETELDR TVIDEIGDPLVHLIRNSIDHGIEAPETRLQKGKPESGKVVLKAYHSGNHVFIEVEDDG AGLNRKKILEKALERGVITEKEAETLEDNQIYELIFAPGFSTADQISDISGRGVGLDV VKNKLESLGGSVSVKSAEGQGSLFSIQLPLTLSIISVLLIKLEEETFAIPISSIIETA VIDRKDILQTHDREVIDFRGHIVPVVYLKEEFKIEDTRKDAEQLHIIVVKKGDKPTAF VVDSFIGQQEVVLKSLGDYLTNVFAISGATILGDGEVALIIDCNALII*" /label="cheA CDS" gene 1625143..1627161 /gene="cheA" /locus_tag="BSU_16430" /old_locus_tag="BSU16430" /label="cheA gene" CDS 1627183..1627653 /gene="cheW" /locus_tag="BSU_16440" /old_locus_tag="BSU16440" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12864845, 15451661, 1624415, 8169223, 8169224" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12864845, 15451661, 1624415, 8169223, 8169224; Product type r: regulator" /codon_start=1 /transl_table=11 /product="modulation of CheA activity in response to attractants (chemotaxis)" /protein_id="NP_389526.1" /db_xref="EnsemblGenomes-Gn:BSU16440" /db_xref="EnsemblGenomes-Tr:CAB13517" /db_xref="GOA:P39802" /db_xref="InterPro:IPR002545" /db_xref="InterPro:IPR036061" /db_xref="SubtiList:BG10692" /db_xref="UniProtKB/Swiss-Prot:P39802" /translation="MTAEIKTGEKMIVFMVNGKEYAISVTQVKSIEKWQKPTRVPGVE PYICGVINLRGVVTPVIDLRKRLNLPEYEITDETRIIIIAYRDIEVGWIVDEANDVIT VHESEIESAPEGVQKDTDVSIEQIVKQENRLLNIIDANAVLDKESSQSAVPDQA*" /label="cheW CDS" gene 1627183..1627653 /gene="cheW" /locus_tag="BSU_16440" /old_locus_tag="BSU16440" /label="cheW gene" CDS 1627672..1628301 /gene="cheC" /locus_tag="BSU_16450" /old_locus_tag="BSU16450" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12920116, 14749334, 14993307, 15546616, 16469702, 18990184, 22720735, 23226535" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12920116, 14749334, 14993307, 15546616, 16469702, 18990184, 22720735, 23226535; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="signal terminating phosphatase of CheR-mediated methylation of methyl-accepting chemotaxis proteins (MCPs)" /protein_id="NP_389527.1" /db_xref="EnsemblGenomes-Gn:BSU16450" /db_xref="EnsemblGenomes-Tr:CAB13518" /db_xref="GOA:P40403" /db_xref="InterPro:IPR007597" /db_xref="InterPro:IPR028976" /db_xref="SubtiList:BG10749" /db_xref="UniProtKB/Swiss-Prot:P40403" /translation="MSIFNGIKEEQMDILREVGNIGAGHSASAMAQLLNRKIDMEVPF AKLLSFDELVDFFGGADVPVASIFLRMEGDLTGSMFFIMPFFQAEQFIRELIGNPDFD IEDLGEDHMSSSALHELGNILAGSYLTALADLTKLQLYPSVPEVSLDMFGAVISEGLM ELSQVGEHAIVVDTSIFDQSHQQELKAHMFMLPDYDSFEKLFVALGASL*" /label="cheC CDS" gene 1627672..1628301 /gene="cheC" /locus_tag="BSU_16450" /old_locus_tag="BSU16450" /label="cheC gene" CDS 1628298..1628798 /gene="cheD" /locus_tag="BSU_16460" /old_locus_tag="BSU16460" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15546616, 16469702, 22720735, 23226535" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15546616, 16469702, 22720735, 23226535; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sequence specific deamidase required for methylation of methyl-accepting chemotaxis proteins (MCPs) by CheR" /protein_id="NP_389528.1" /db_xref="EnsemblGenomes-Gn:BSU16460" /db_xref="EnsemblGenomes-Tr:CAB13519" /db_xref="GOA:P40404" /db_xref="InterPro:IPR005659" /db_xref="InterPro:IPR011324" /db_xref="SubtiList:BG10750" /db_xref="UniProtKB/Swiss-Prot:P40404" /translation="MSTTEAVVIKVGIADVKIARFPDTIRTSGLGSCVGLVLYDKEKQ TAGLVHVMLPDSTLSKTAELNRAKYADTAVQTTIDMLIEAGCRKFALKAKLAGGSEMF KFKSTNDLMKIGPRNVLAIKEQLSLFNIPIISEDTGGSSGRTIEFEPKSCMLHIRTVK QGEKTI*" /label="cheD CDS" gene 1628298..1628798 /gene="cheD" /locus_tag="BSU_16460" /old_locus_tag="BSU16460" /label="cheD gene" CDS 1628821..1629585 /gene="sigD" /locus_tag="BSU_16470" /old_locus_tag="BSU16470" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:2498284, 9648743, 9657996, 11751842, 15033535, 15066026, 15175317, 22329926, 22956758, 25288929, 26170408" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2498284, 9648743, 9657996, 11751842, 15033535, 15066026, 15175317, 22329926, 22956758, 25288929, 26170408; Product type r : regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase sigma-28 factor (sigma-D)" /protein_id="NP_389529.1" /db_xref="EnsemblGenomes-Gn:BSU16470" /db_xref="EnsemblGenomes-Tr:CAB13520" /db_xref="GOA:P10726" /db_xref="InterPro:IPR000943" /db_xref="InterPro:IPR007624" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR007630" /db_xref="InterPro:IPR012845" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10751" /db_xref="UniProtKB/Swiss-Prot:P10726" /translation="MQSLNYEDQVLWTRWKEWKDPKAGDDLMRRYMPLVTYHVGRISV GLPKSVHKDDLMSLGMLGLYDALEKFDPSRDLKFDTYASFRIRGAIIDGLRKEDWLPR TSREKTKKVEAAIEKLEQRYLRNVSPAEIAEELGMTVQDVVSTMNEGFFANLLSIDEK LHDQDDGENIQVMIRDDKNVPPEEKIMKDELIAQLAEKIHELSEKEQLVVSLFYKEEL TLTEIGQVLNLSTSRISQIHSKALFKLKNLLEKVIQ*" /label="sigD CDS" gene 1628821..1629585 /gene="sigD" /locus_tag="BSU_16470" /old_locus_tag="BSU16470" /label="sigD gene" promotor_-35 1629595..1629601 /Source="Nicolas_upshift_promotors" /id="U1327" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.665334665334665" /psig="0.665334665334665" /xcortree=682 /SigmaFactorBS="aaaagtgatacaataatgaatttcaTGGTTAGcgagtgaaaa acatGTCAACACTATTatggcttttaagctttatgctccacggcgttcttctgtacgc t" /listShort="ylxL" /listLong="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" CDS 1629614..1630117 /gene="swrB" /locus_tag="BSU_16480" /old_locus_tag="BSU16480" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15066026, 15175317, 19202088, 21736639, 26244495" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15066026, 15175317, 19202088, 21736639, 26244495; Product type r: regulator" /codon_start=1 /transl_table=11 /product="coupling factor for flagellin transcription and translation" /protein_id="NP_389530.1" /db_xref="EnsemblGenomes-Gn:BSU16480" /db_xref="EnsemblGenomes-Tr:CAB13521" /db_xref="SubtiList:BG10752" /db_xref="UniProtKB/Swiss-Prot:P40405" /translation="MSTLLWLLSFMLHGVLLYAVIILYTRLAAVKETEKQQKQILEET ENTLAAFLLELKEENEKLIENKASSASQSDEESQKSGLQTSETYQERDPVQEAENLPE HIEGLITEVDRREELVNSEVQSFEDQVIELYEQGYSASQIAQKMKSGKTEIELFLKFR SKGVKDS*" /label="swrB CDS" gene 1629614..1630117 /gene="swrB" /locus_tag="BSU_16480" /old_locus_tag="BSU16480" /label="swrB gene" promotor_-10 1629616..1629627 /Source="Nicolas_upshift_promotors" /id="U1327" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.665334665334665" /psig="0.665334665334665" /xcortree=682 /SigmaFactorBS="aaaagtgatacaataatgaatttcaTGGTTAGcgagtgaaaa acatGTCAACACTATTatggcttttaagctttatgctccacggcgttcttctgtacgc t" /listShort="ylxL" /listLong="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1629630 /Source="Nicolas_upshifts" /id="U1327" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.665334665334665" /psig="0.665334665334665" /xcortree=682 /SigmaFactorBS="aaaagtgatacaataatgaatttcaTGGTTAGcgagtgaaaa acatGTCAACACTATTatggcttttaagctttatgctccacggcgttcttctgtacgc t" /listShort="ylxL" /listLong="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" promotor_-35 1630113..1630119 /Source="Nicolas_upshift_promotors" /id="U1328" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.782217782217782" /psig=1 /xcortree=2651 /SigmaFactorBS="ctatttttaaaatttcgctccaaaggtgtaaaggattCTTGA TTgtcggataaagctgTGTTATATTATGTCTTGGTGttaaatacacacgcttaacgat t" /listShort="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1630134..1630153 /Source="Nicolas_upshift_promotors" /id="U1328" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.782217782217782" /psig=1 /xcortree=2651 /SigmaFactorBS="ctatttttaaaatttcgctccaaaggtgtaaaggattCTTGA TTgtcggataaagctgTGTTATATTATGTCTTGGTGttaaatacacacgcttaacgat t" /listShort="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" S_feature 1630136..1630260 /Source="Nicolas_S_feature" /locus_tag="new_1717808_1717932" /HighExp="GM 45, GM 15, H2O2, M9-exp, LBGexp, C30, MG 90, GM-0.1, G135, SMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigGF, SigD, SigA, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.665, 1, 0.994, 0.998, 1, 0.999, 1, 1, 1" /label="S586" upshifts 1630136 /Source="Nicolas_upshifts" /id="U1328" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.782217782217782" /psig=1 /xcortree=2651 /SigmaFactorBS="ctatttttaaaatttcgctccaaaggtgtaaaggattCTTGA TTgtcggataaagctgTGTTATATTATGTCTTGGTGttaaatacacacgcttaacgat t" /listShort="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" CDS 1630261..1631001 /gene="rpsB" /locus_tag="BSU_16490" /old_locus_tag="BSU16490" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9090122, 10675340, 12682299; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S2" /protein_id="NP_389531.1" /db_xref="EnsemblGenomes-Gn:BSU16490" /db_xref="EnsemblGenomes-Tr:CAB13522" /db_xref="GOA:P21464" /db_xref="InterPro:IPR001865" /db_xref="InterPro:IPR005706" /db_xref="InterPro:IPR018130" /db_xref="InterPro:IPR023591" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19004" /db_xref="UniProtKB/Swiss-Prot:P21464" /translation="MSVISMKQLLEAGVHFGHQTRRWNPKMKRYIFTERNGIYIIDLQ KTVKKVEEAYNFTKNLAAEGGKILFVGTKKQAQDSVKEEAQRSGMYYVNQRWLGGTLT NFETIQKRIKRLKDIEKMQENGTFDVLPKKEVVQLKKELERLEKFLGGIKDMKDLPDA LFIIDPRKERIAVAEARKLNIPIIGIVDTNCDPDEIDVVIPANDDAIRAVKLLTSKMA DAILEAKQGEEEAEVAEETAPETETTTA*" /label="rpsB CDS" gene 1630261..1631001 /gene="rpsB" /locus_tag="BSU_16490" /old_locus_tag="BSU16490" /label="rpsB gene" downshifts 1630983 /Source="Nicolas_upshifts" /id="D896" /incds=0 /nref=4 /ntot=61 /MaxReadThrough="9.04923" /MaxDrop="4.1312" /score="7.42766835" /energy="-14.3" /TU="U1324,U1328" /idTUdmin="U1323" /TUdmin=869 /isTUend="FALSE" /label="downshifts" S_feature 1631028..1631102 /Source="Nicolas_S_feature" /locus_tag="new_1718700_1718774" /HighExp="LPh, dia0, G150, G180, LBGexp, Lbexp, HPh, Oxctl, dia15, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigGF, SigD, SigA, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.665, 1, 0.994, 0.998, 1, 0.999, 1, 1, 1" /label="S587" CDS 1631103..1631984 /gene="tsf" /locus_tag="BSU_16500" /old_locus_tag="BSU16500" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 6396082, 9244380, 9973356, 27624934; Product type f: factor" /codon_start=1 /transl_table=11 /product="elongation factor Ts" /protein_id="NP_389532.1" /db_xref="EnsemblGenomes-Gn:BSU16500" /db_xref="EnsemblGenomes-Tr:CAB13523" /db_xref="GOA:P80700" /db_xref="InterPro:IPR001816" /db_xref="InterPro:IPR009060" /db_xref="InterPro:IPR014039" /db_xref="InterPro:IPR018101" /db_xref="InterPro:IPR036402" /db_xref="SubtiList:BG19025" /db_xref="UniProtKB/Swiss-Prot:P80700" /translation="MAITAQQVKELREKTGAGMMDCKKALTETDGDMDKAIDLLREKG IAKAAKKADRIAAEGSTLIKTDGNKGVILEVNSETDFVAKNEGFKELLNTLADHLLAN TPADVEEAMGQKMENGSTVEEYITSAVAKIGEKITLRRFTVLTKDDSSAFGAYLHMGG RIGVLTVLNGTTDEETAKDIAMHVAAVNPRYISRDQVSEEETNHERQILTQQALQEGK PENIVAKMVEGRLNKFFEEICLLDQAFVKNPDEKVKQVIAAKNATVQTFVRYEVGEGI EKRQENFAEEVMNQVKK*" /label="tsf CDS" gene 1631103..1631984 /gene="tsf" /locus_tag="BSU_16500" /old_locus_tag="BSU16500" /label="tsf gene" S_feature 1631985..1632129 /Source="Nicolas_S_feature" /locus_tag="new_1719657_1719801" /HighExp="LBGexp, G150, LBGtran, G135, G180, LPh, Oxctl, dia0, Lbexp, M9-exp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigGF, SigD, SigA, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.665, 1, 0.994, 0.998, 1, 0.999, 1, 1, 1" /label="S588" CDS 1632130..1632852 /gene="pyrH" /locus_tag="BSU_16510" /old_locus_tag="BSU16510" /EC_number="2.7.4.22" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9862121, 12682299, 12869195, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9862121, 12682299, 12869195, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="uridylate kinase" /protein_id="NP_389533.2" /db_xref="EnsemblGenomes-Gn:BSU16510" /db_xref="EnsemblGenomes-Tr:CAB13524" /db_xref="GOA:O31749" /db_xref="InterPro:IPR001048" /db_xref="InterPro:IPR011817" /db_xref="InterPro:IPR015963" /db_xref="InterPro:IPR036393" /db_xref="SubtiList:BG12675" /db_xref="UniProtKB/Swiss-Prot:O31749" /translation="MEKPKYKRIVLKLSGEALAGEQGNGINPTVIQSIAKQVKEIAEL EVEVAVVVGGGNLWRGKTGSDLGMDRATADYMGMLATVMNSLALQDSLETLGIQSRVQ TSIEMRQVAEPYIRRKAIRHLEKKRVVIFAAGTGNPYFSTDTTAALRAAEIEADVILM AKNNVDGVYNADPRKDESAVKYESLSYLDVLKDGLEVMDSTASSLCMDNDIPLIVFSI MEEGNIKRAVIGESIGTIVRGK*" /label="pyrH CDS" gene 1632130..1632852 /gene="pyrH" /locus_tag="BSU_16510" /old_locus_tag="BSU16510" /label="pyrH gene" CDS 1632854..1633411 /gene="frr" /locus_tag="BSU_16520" /old_locus_tag="BSU16520" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9862121, 12480895, 12682299, 14586115; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosome recycling factor" /protein_id="NP_389534.1" /db_xref="EnsemblGenomes-Gn:BSU16520" /db_xref="EnsemblGenomes-Tr:CAB13525" /db_xref="GOA:P81101" /db_xref="InterPro:IPR002661" /db_xref="InterPro:IPR023584" /db_xref="InterPro:IPR036191" /db_xref="SubtiList:BG12587" /db_xref="UniProtKB/Swiss-Prot:P81101" /translation="MSKEVLTQTKEKMEKAIAAYQRELATVRAGRANPSLLDKVTVEY YGAQTPLNQLSSINVPEARMLVITPYDKTAIGDIEKAILKADLGLTPTSDGNMIRIAI PALTEERRKELVKVVKKYAEEAKVAVRNVRRDANDDLKKLEKNGDITEDELRASTEDV QKLTDEYVSKIDSVTKDKEKEIMEV*" /label="frr CDS" gene 1632854..1633411 /gene="frr" /locus_tag="BSU_16520" /old_locus_tag="BSU16520" /label="frr gene" downshifts complement(1633358) /Source="Nicolas_upshifts" /id="D897" /incds=0 /nref=1 /ntot=70 /MaxReadThrough="3.38183" /MaxDrop="3.17183" /score="-5.69560888" /energy="-4.8" /TU="NA" /idTUdmin="U1326" /TUdmin="-10739" /isTUend="FALSE" /label="downshifts" promotor_-35 1633400..1633403 /Source="Nicolas_upshift_promotors" /id="U1329" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.773226773226773" /xcortree=536 /SigmaFactorBS="acaaaagacaaagaaaaagaaatcATGGaagtttaatgaaaa ACTATGTACAATAGATAATAgtgaaaagaccctctcatgtttacagggggtttttttg t" /listShort="S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1633418..1633437 /Source="Nicolas_upshift_promotors" /id="U1329" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.773226773226773" /xcortree=536 /SigmaFactorBS="acaaaagacaaagaaaaagaaatcATGGaagtttaatgaaaa ACTATGTACAATAGATAATAgtgaaaagaccctctcatgtttacagggggtttttttg t" /listShort="S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" S_feature 1633436..1633541 /Source="Nicolas_S_feature" /locus_tag="new_1721108_1721213" /HighExp="G180, G135, T3.30H, Oxctl, G150, Cold, Paraq, C30, T3.0H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.773, 1, 0.998" /TUlongSig="SigGF, SigD, SigA, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.665, 1, 0.994, 0.998, 1, 0.999, 1, 1, 1" /label="S589" upshifts 1633436 /Source="Nicolas_upshifts" /id="U1329" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.773226773226773" /xcortree=536 /SigmaFactorBS="acaaaagacaaagaaaaagaaatcATGGaagtttaatgaaaa ACTATGTACAATAGATAATAgtgaaaagaccctctcatgtttacagggggtttttttg t" /listShort="S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" CDS 1633542..1634324 /gene="uppS" /locus_tag="BSU_16530" /old_locus_tag="BSU16530" /EC_number="2.5.1.31" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15788389, 16014871, 22904278, 23840410, 27578312" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15788389, 16014871, 22904278, 23840410, 27578312; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="undecaprenyl pyrophosphate synthase" /protein_id="NP_389535.1" /db_xref="EnsemblGenomes-Gn:BSU16530" /db_xref="EnsemblGenomes-Tr:CAB13526" /db_xref="GOA:O31751" /db_xref="InterPro:IPR001441" /db_xref="InterPro:IPR018520" /db_xref="InterPro:IPR036424" /db_xref="SubtiList:BG13408" /db_xref="UniProtKB/Swiss-Prot:O31751" /translation="MLNILKNWKNQQTAASNLERYTKEDILKGEIPEHIAIIMDGNGR WAKKRSLPRIAGHHEGMKVVKRTTKLANELGVKVLTLYAFSTENWKRPKMEVDFLMKL PEEFLNTYLPELVEENVQVRIIGDETALPAHTLRAIEKAVQDTAQNDGMILNFALNYG GRTEIVSAAKSLAEKVKEGSLNIEDIDESLFSTYLMTESLQDPELLIRTSGEIRLSNF MLWQVAYSEFVFTDVLWPDFKEDHFLQALGEFQQRGRRFGGI*" /label="uppS CDS" gene 1633542..1634324 /gene="uppS" /locus_tag="BSU_16530" /old_locus_tag="BSU16530" /label="uppS gene" CDS 1634328..1635137 /gene="cdsA" /locus_tag="BSU_16540" /old_locus_tag="BSU16540" /EC_number="2.7.7.41" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 175832, 12682299, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphatidate cytidylyltransferase (CDP-diglyceride synthase)" /protein_id="NP_389536.1" /db_xref="EnsemblGenomes-Gn:BSU16540" /db_xref="EnsemblGenomes-Tr:CAB13527" /db_xref="GOA:O31752" /db_xref="InterPro:IPR000374" /db_xref="SubtiList:BG12575" /db_xref="UniProtKB/Swiss-Prot:O31752" /translation="MVDMKQRILTGVLAAIVFLFLVIVGKLPFTILIYAMGSVALFEL LRMKKLKLVSLPGLIGLLLLWMFLLPSQYSFFEADGISKMEIALFAVLLLLTYTVLVK NTFTFDEVGFITLAAIYIGMCFHYFIEIRNLDQYGLTYIFYACVVIWSTDSGAYFVGK SLGKRKLWPEISPNKTVEGFAGGIVIALVLATIFQLVAQLPIPYIYLLLITLFLSVFG QLGDLVESALKRHYDVKDSGNILPGHGGILDRFDSFLFVMPFLYFLLALFS*" /label="cdsA" gene 1634328..1635137 /gene="cdsA" /locus_tag="BSU_16540" /old_locus_tag="BSU16540" /label="cdsA gene" promotor_-35 1635118..1635125 /Source="Nicolas_upshift_promotors" /id="U1330" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.958041958041958" /psig=1 /xcortree=2056 /SigmaFactorBS="gacagtttcttgtttgtcatgcctttcttgtactttcTGCTT GCCcttttttcataaaaAAGTCTAATATGAATATGAGactgatcatgcagcaataaga a" /listShort="dxr, rseP, proS, S590, polC, S591, S592" /listLong="S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1635140..1635159 /Source="Nicolas_upshift_promotors" /id="U1330" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.958041958041958" /psig=1 /xcortree=2056 /SigmaFactorBS="gacagtttcttgtttgtcatgcctttcttgtactttcTGCTT GCCcttttttcataaaaAAGTCTAATATGAATATGAGactgatcatgcagcaataaga a" /listShort="dxr, rseP, proS, S590, polC, S591, S592" /listLong="S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1635141 /Source="Nicolas_upshifts" /id="U1330" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.958041958041958" /psig=1 /xcortree=2056 /SigmaFactorBS="gacagtttcttgtttgtcatgcctttcttgtactttcTGCTT GCCcttttttcataaaaAAGTCTAATATGAATATGAGactgatcatgcagcaataaga a" /listShort="dxr, rseP, proS, S590, polC, S591, S592" /listLong="S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" CDS 1635199..1636350 /gene="dxr" /locus_tag="BSU_16550" /old_locus_tag="BSU16550" /EC_number="1.1.1.267" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15567415, 17458547, 21296950, 23840410" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15567415, 17458547, 21296950, 23840410; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="1-deoxy-D-xylulose-5-phosphate reductoisomerase" /protein_id="NP_389537.2" /db_xref="EnsemblGenomes-Gn:BSU16550" /db_xref="EnsemblGenomes-Tr:CAB13528" /db_xref="GOA:O31753" /db_xref="InterPro:IPR003821" /db_xref="InterPro:IPR013512" /db_xref="InterPro:IPR013644" /db_xref="InterPro:IPR026877" /db_xref="InterPro:IPR036169" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13409" /db_xref="UniProtKB/Swiss-Prot:O31753" /translation="MKNICLLGATGSIGEQTLDVLRAHQDQFQLVSMSFGRNIDKAVP MIEVFQPKFVSVGDLDTYHKLKQMSFSFECQIGLGEEGLIEAAVMEEVDIVVNALLGS VGLIPTLKAIEQKKTIALANKETLVTAGHIVKEHAKKYDVPLLPVDSEHSAIFQALQG EQAKNIERLIITASGGSFRDKTREELESVTVEDALKHPNWSMGAKITIDSATMMNKGL EVIEAHWLFDIPYEQIDVVLHKESIIHSMVEFHDKSVIAQLGTPDMRVPIQYALTYPD RLPLPDAKRLELWEIGSLHFEKADFDRFRCLQFAFESGKIGGTMPTVLNAANEVAVAA FLAGKIPFLAIEDCIEKALTRHQLLKKPSLADIQEVDKDTRGYVNSILT*" /label="dxr CDS" gene 1635199..1636350 /gene="dxr" /locus_tag="BSU_16550" /old_locus_tag="BSU16550" /label="dxr gene" CDS 1636357..1637625 /gene="rasP" /locus_tag="BSU_16560" /old_locus_tag="BSU16560" /EC_number="3.4.24.-" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15130127, 15496982, 15520285, 16014871, 16899079, 18599827, 19889088, 20644139, 21810987, 26735940, 28376795, 28674070" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15130127, 15496982, 15520285, 16014871, 16899079, 18599827, 19889088, 20644139, 21810987, 26735940, 28376795, 28674070; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="inner membrane zinc metalloprotease required forthe extracytoplasmic stress response mediated by sigma(W)" /protein_id="NP_389538.1" /db_xref="EnsemblGenomes-Gn:BSU16560" /db_xref="EnsemblGenomes-Tr:CAB13529" /db_xref="GOA:O31754" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR004387" /db_xref="InterPro:IPR008915" /db_xref="InterPro:IPR036034" /db_xref="SubtiList:BG13410" /db_xref="UniProtKB/Swiss-Prot:O31754" /translation="MFVNTVIAFIIIFGTLVFFHELGHLLLAQRAGILCREFAIGFGP KIFSFKKNETVYTIRLLPVGGFVRMAGEDPEMIEVKPGYTVGLLFNKEDQVEKVIINQ KEKYPDALVIEVETADLEHDMKITGYEQGKEDELSSFTVSETSFFIVDGEEVQIAPYN RQFGSKPVWQRIKAIAAGPIMNFILAYVILVMLGLIQGVPSNEPMLGQLTDNGRAAEA GLKEGDYIQSINGEKMRSWTDIVSAVKENPEKEMDVAVKRDNKTLHISVTPEAVKDEN KKTIGRFGSYAPTEKGVLSAVAYGATSTVDVTKAILTNLSKLVTGQFKLDMLSGPVGI YDMTDQVAKTGIVNLFQFAAFLSINLGIVNLLPIPALDGGRLLFLFIEAIRGKPINRE KEAFVVFIGVAFLMLLMLVVTWNDIQRLFL*" /label="rasP CDS" gene 1636357..1637625 /gene="rasP" /locus_tag="BSU_16560" /old_locus_tag="BSU16560" /label="rasP gene" CDS 1637658..1639352 /gene="proS" /locus_tag="BSU_16570" /old_locus_tag="BSU16570" /EC_number="6.1.1.15" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 16864571, 26886480; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="prolyl-tRNA synthetase" /protein_id="NP_389539.1" /db_xref="EnsemblGenomes-Gn:BSU16570" /db_xref="EnsemblGenomes-Tr:CAB13530" /db_xref="GOA:O31755" /db_xref="InterPro:IPR002314" /db_xref="InterPro:IPR002316" /db_xref="InterPro:IPR004154" /db_xref="InterPro:IPR004500" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR007214" /db_xref="InterPro:IPR023717" /db_xref="InterPro:IPR033730" /db_xref="InterPro:IPR036621" /db_xref="InterPro:IPR036754" /db_xref="SubtiList:BG12659" /db_xref="UniProtKB/Swiss-Prot:O31755" /translation="MRQSLTLIPTLREVPADAEAKSHQLLLRAGFIRQNTSGVYSYMP LAYKVIQNIQQIVREEMEKIDAVEMLMPALQQAETWQESGRWYTYGPELMRLKDRHGR EFALGATHEEVITSLVRDEVKSYKRLPLTLYQIQSKFRDEKRPRFGLLRGREFIMKDA YSFHASAESLDETYQKMYEAYSNIFARCGINVRPVIADSGAMGGKDTHEFMALSAIGE DTIAYSDESQYAANIEMAEVLHQEVPSDEEPKALEKVHTPNVKTIEELTAFLQVSAEA CIKSVLFKADDRFVLVLVRGDHEVNDIKVKNLLHAEVVELATHEEVIQQLGTEPGFVG PVGIHQDVEVYADQAVKAMVNAVAGANEGDHHYKNVNVNRDAQIKEFADLRFIKEGDP SPDGKGTIRFAEGIEVGQVFKLGTRYSEAMNATYLDENGRAQPMLMGCYGIGVSRTLS AIAEQHHDEKGLIWPKSVAPYDLHILALNMKNDGQRELAEKLYADLKAEGYEVLYDDR AERAGVKFADSDLIGLPIRITVGKRADEGIVEVKIRQTGESTEISVDELSAFISKQ*" /label="proS CDS" gene 1637658..1639352 /gene="proS" /locus_tag="BSU_16570" /old_locus_tag="BSU16570" /label="proS gene" S_feature 1639353..1639460 /Source="Nicolas_S_feature" /locus_tag="new_1727025_1727132" /HighExp="G135, G180, G150, C30, Oxctl, H2O2, Paraq, LPh, LBGexp, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="1, 0.773, 1, 0.998" /TUlongSig="SigGF, SigD, SigA, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.665, 1, 0.994, 0.998, 1, 0.999, 1, 1, 1" /label="S590" CDS 1639461..1643774 /gene="polC" /locus_tag="BSU_16580" /old_locus_tag="BSU16580" /EC_number="2.7.7.7" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:11721055, 12081953, 12217498, 20122408, 21740522, 24106089, 28575448" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11721055, 12081953, 12217498, 20122408, 21740522, 24106089, 28575448; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase III (alpha subunit)" /protein_id="NP_389540.1" /db_xref="EnsemblGenomes-Gn:BSU16580" /db_xref="EnsemblGenomes-Tr:CAB13531" /db_xref="GOA:P13267" /db_xref="InterPro:IPR003141" /db_xref="InterPro:IPR004013" /db_xref="InterPro:IPR006054" /db_xref="InterPro:IPR006308" /db_xref="InterPro:IPR011708" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR013520" /db_xref="InterPro:IPR024754" /db_xref="InterPro:IPR028112" /db_xref="InterPro:IPR029460" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG10263" /db_xref="UniProtKB/Swiss-Prot:P13267" /translation="MEQLSVNRRQFQILLQQINMTDDTFMTYFEHGEIKKLTIHKASK SWHFHFQFKSLLPFQIYDTLTTRLTQSFAHIAKVTSSIEVQDAEVSESIVQDYWSRCI EELQGISPPIISLLNQQKPKLKGNKLIVKTKTDTEAAALKNKYSSMIQAEYRQFGFPD LQLDAEIFVSEQEVQKFREQKLAEDQERAMQALIEMEKKDKESDEDQAPSGPLVIGYQ IKDNEEIRTLDSIMDEERRITVQGYVFDVETRELKSGRTLCIFKITDYTNSILIKMFA REKEDAALMKSLKKGMWVKARGSIQNDTFVRDLVMIANDVNEIKAKTREDSAPEGEKR VELHLHSPMSQMDAVTGIGKLVEQAKKWGHEAIALTDHAVVQSFPDAYSAAKKHGIKM IYGMEANLVDDGVPIAYNAAHRLLEEETYVVFDVETTGLSAVYDTIIELAAVKVKGGE IIDKFEAFANPHRPLSATIIELTGITDDMLQDAPDVVDVIRDFREWIGDDILVAHNAS FDMGFLNVAYKKLLEVEKAKNPVIDTLELGRFLYPEFKNHRLNTLCKKFDIELTQHHR AIYDTEATAYLLLKMLKDAAEKGIQYHDELNENMGQSNAYQRSRPYHATLLAVNSTGL KNLFKLVSLSHIHYFYRVPRIPRSQLEKYREGLLIGSACDRGEVFEGMMQKSPEEVED IASFYDYLEVQPPEVYRHLLELELVRDEKALKEIIANITKLGEKLNKPVVATGNVHYL NDEDKIYRKILISSQGGANPLNRHELPKVHFRTTDEMLEAFSFLGEEKAKEIVVTNTQ KVASLVDDIKPIKDDLYTPKIEGADEEIREMSYQRARSIYGEELPEIVEARIEKELKS IIGHGFAVIYLISHKLVKRSLDDGYLVGSRGSVGSSLVATLTEITEVNPLPPHYVCPE CQHSEFFNDGSVGSGFDLPDKTCPHCGTPLKKDGHDIPFETFLGFKGDKVPDIDLNFS GEYQPQAHNYTKVLFGEDNVYRAGTIGTVAEKTAYGYVKGYAGDNNLHMRGAEIDRLV QGCTGVKRTTGQHPGGIIVVPDYMDIYDFSPIQFPADATGSEWKTTHFDFHSIHDNLL KLDILGHDDPTVIRMLQDLSGIDPKTIPTDDPEVMKIFQGTESLGVTEEQIGCKTGTL GIPEFGTRFVRQMLEDTKPTTFSELVQISGLSHGTDVWLGNAQELIHNNICELSEVIG CRDDIMVYLIYQGLEPSLAFKIMEFVRKGKGLTPEWEEEMKNNNVPDWYIDSCKKIKY MFPKAHAAAYVLMAVRIAYFKVHHALLYYAAYFTVRADDFDIDTMIKGSTAIRAVMED INAKGLDASPKEKNLLTVLELALEMCERGYSFQKVDLYRSSATEFIIDGNSLIPPFNS IPGLGTNAALNIVKAREEGEFLSKEDLQKRGKVSKTILEYLDRHGCLESLPDQNQLSL F*" /label="polC CDS" gene 1639461..1643774 /gene="polC" /locus_tag="BSU_16580" /old_locus_tag="BSU16580" /label="polC gene" S_feature 1643775..1643839 /Source="Nicolas_S_feature" /locus_tag="new_1731447_1731511" /HighExp="C30, G180, G135, Oxctl, G150, H2O2, Paraq, Cold, LBGstat, Glucon" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="1, 0.773, 1, 0.998" /TUlongSig="SigGF, SigD, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.665, 1, 0.998, 1, 0.999, 1, 1, 1" /label="S591" misc_RNA 1643785..1644002 /gene="surG" /locus_tag="BSU_misc_RNA_71" /product="small RNAs controlled by sporulation" /experiment="publication(s) with functional evidences, PMID:16385044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16385044; Product type n: RNA" /label="surG RNA" gene 1643785..1644002 /gene="surG" /locus_tag="BSU_misc_RNA_71" /label="surG gene" promotor_-35 1643811..1643817 /Source="Nicolas_upshift_promotors" /id="U1331" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=881 /SigmaFactorBS="aagcagaatttctcagaaattctgcttctaTGCATACataag cgcaaaaagTGCCATCGTAATattagagtttctgtcacttgcttaggtatgaaggtaa g" /listShort="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB" /listLong="ribC, S594, rpsO, S595, pnpA, S596, ylxY" /label="promotor_-35" promotor_-10 1643832..1643843 /Source="Nicolas_upshift_promotors" /id="U1331" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=881 /SigmaFactorBS="aagcagaatttctcagaaattctgcttctaTGCATACataag cgcaaaaagTGCCATCGTAATattagagtttctgtcacttgcttaggtatgaaggtaa g" /listShort="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB" /listLong="ribC, S594, rpsO, S595, pnpA, S596, ylxY" /label="promotor_-10" S_feature 1643841..1643908 /Source="Nicolas_S_feature" /locus_tag="new_1731513_1731580" /HighExp="S7, S5, S4, S8, S6, S3, G180, C30, T5.0H, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigA" /TUshortPSig="0.998, 1" /TUlongSig="SigA, SigA, SigGF, SigA, SigD, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.773, 1, 0.665, 0.998, 1, 0.998, 1, 0.999, 1, 1, 1" /label="S592" upshifts 1643841 /Source="Nicolas_upshifts" /id="U1331" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=881 /SigmaFactorBS="aagcagaatttctcagaaattctgcttctaTGCATACataag cgcaaaaagTGCCATCGTAATattagagtttctgtcacttgcttaggtatgaaggtaa g" /listShort="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB" /listLong="ribC, S594, rpsO, S595, pnpA, S596, ylxY" /label="upshifts" promotor_-35 1643891..1643897 /Source="Nicolas_upshift_promotors" /id="U1332" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.441558441558442" /psig=1 /xcortree=2495 /SigmaFactorBS="gtttctgtcacttgcttaggtatgaaggtaagcgtatatccA TTTGCAataaaaatatggtTATGGTATAGTTTTATTGGAaatgctaacgattaccgag g" /listShort="S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY" /listLong="mlpA" /label="promotor_-35" S_feature 1643910..1644103 /Source="Nicolas_S_feature" /locus_tag="new_1731582_1731775" /HighExp="LoTm, Cold, HPh, G180, Paraq, Oxctl, T-5.40H, BMM, G150, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF" /TUshortPSig="1, 0.998" /TUlongSig="SigA, SigA, SigA, SigGF, SigA, SigD, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="1, 0.773, 1, 0.665, 0.998, 1, 0.998, 1, 0.999, 1, 1, 1" /label="S593" upshifts 1643910 /Source="Nicolas_upshifts" /id="U1332" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.441558441558442" /psig=1 /xcortree=2495 /SigmaFactorBS="gtttctgtcacttgcttaggtatgaaggtaagcgtatatccA TTTGCAataaaaatatggtTATGGTATAGTTTTATTGGAaatgctaacgattaccgag g" /listShort="S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY" /listLong="mlpA" /label="upshifts" promotor_-10 1643911..1643930 /Source="Nicolas_upshift_promotors" /id="U1332" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.441558441558442" /psig=1 /xcortree=2495 /SigmaFactorBS="gtttctgtcacttgcttaggtatgaaggtaagcgtatatccA TTTGCAataaaaatatggtTATGGTATAGTTTTATTGGAaatgctaacgattaccgag g" /listShort="S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY" /listLong="mlpA" /label="promotor_-10" CDS 1644104..1644574 /gene="rimP" /locus_tag="BSU_16590" /old_locus_tag="BSU16590" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15257761, 16014871, 19150615, 20188109, 21529161; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosome maturation factor" /protein_id="NP_389541.1" /db_xref="EnsemblGenomes-Gn:BSU16590" /db_xref="EnsemblGenomes-Tr:CAB13532" /db_xref="GOA:P32726" /db_xref="InterPro:IPR003728" /db_xref="InterPro:IPR028989" /db_xref="InterPro:IPR028998" /db_xref="InterPro:IPR035956" /db_xref="InterPro:IPR036847" /db_xref="SubtiList:BG10264" /db_xref="UniProtKB/Swiss-Prot:P32726" /translation="MSKKVTDTVQEMAQPIVDSLQLELVDIEFVKEGQSWFLRVFIDS DDGVDIEECAKVSEALSEKLDEADPISQNYFLEVSSPGAERPLKKKADFEKSLGKNVY IKTYEPIDGVKVFEGELAEFDGQTVTVEITIKTRKKRINIPYEKIANARLAVTF*" /label="rimP CDS" gene 1644104..1644574 /gene="rimP" /locus_tag="BSU_16590" /old_locus_tag="BSU16590" /label="rimP gene" downshifts complement(1644425) /Source="Nicolas_upshifts" /id="D898" /incds=1 /nref=3 /ntot=136 /MaxReadThrough="2.08299" /MaxDrop="3.17419" /score="-8.18111474" /energy="-9.2" /TU="NA" /idTUdmin="U1333" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 1644609..1645724 /gene="nusA" /locus_tag="BSU_16600" /old_locus_tag="BSU16600" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15978071, 16707701, 16946247, 27571753, 28507243" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15978071, 16707701, 16946247, 27571753, 28507243; Product type f : factor" /codon_start=1 /transl_table=11 /product="transcription translation coupling factor involved in Rho-dependent transcription termination" /protein_id="NP_389542.1" /db_xref="EnsemblGenomes-Gn:BSU16600" /db_xref="EnsemblGenomes-Tr:CAB13533" /db_xref="GOA:P32727" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR004087" /db_xref="InterPro:IPR009019" /db_xref="InterPro:IPR010213" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR013735" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR022967" /db_xref="InterPro:IPR025249" /db_xref="InterPro:IPR030842" /db_xref="InterPro:IPR036555" /db_xref="PDB:2MT4" /db_xref="SubtiList:BG10265" /db_xref="UniProtKB/Swiss-Prot:P32727" /translation="MSSELLDALTILEKEKGISKEIIIEAIEAALISAYKRNFNQAQN VRVDLNRETGSIRVFARKDVVDEVYDQRLEISIEEAQGIHPEYMVGDVVEIEVTPKDF GRIAAQTAKQVVTQRVREAERGVIYSEFIDREEDIMTGIVQRLDNKFIYVSLGKIEAL LPVNEQMPNESYKPHDRIKVYITKVEKTTKGPQIYVSRTHPGLLKRLFEIEVPEIYDG TVELKSVAREAGDRSKISVRTDDPDVDPVGSCVGPKGQRVQAIVNELKGEKIDIVNWS SDPVEFVANALSPSKVLDVIVNEEEKATTVIVPDYQLSLAIGKRGQNARLAAKLTGWK IDIKSETDARELGIYPRELEEDDEPLFTEPETAESDE*" /label="nusA CDS" gene 1644609..1645724 /gene="nusA" /locus_tag="BSU_16600" /old_locus_tag="BSU16600" /label="nusA gene" promotor_no_box complement(1644671..1644771) /Source="Nicolas_upshift_promotors" /id="U1333" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.775224775224775" /psig="0.171828171828172" /xcortree=61 /SigmaFactorBS="agccagtttcacggtttagatccacccgtacattttgcgctt gattaaaattccgcttataagcagaaattaacgcagcttcgattgcttcgatgataat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1644711) /Source="Nicolas_upshifts" /id="U1333" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.775224775224775" /psig="0.171828171828172" /xcortree=61 /SigmaFactorBS="agccagtttcacggtttagatccacccgtacattttgcgctt gattaaaattccgcttataagcagaaattaacgcagcttcgattgcttcgatgataat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1645738..1646013 /gene="rulR" /locus_tag="BSU_16610" /old_locus_tag="BSU16610" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11679764, 12682299, 26771646, 27435445; Product type f: factor" /codon_start=1 /transl_table=11 /product="molecular ruler co-factor for RNA; new fold" /protein_id="NP_389543.1" /db_xref="EnsemblGenomes-Gn:BSU16610" /db_xref="EnsemblGenomes-Tr:CAB13534" /db_xref="InterPro:IPR007393" /db_xref="InterPro:IPR035931" /db_xref="SubtiList:BG10266" /db_xref="UniProtKB/Swiss-Prot:P32728" /translation="MNKHKKIPLRKCVVTGEMKPKKELIRVVRSKEGEISVDPTGKKN GRGAYLTLDKECILAAKKKNTLQNQFQSQIDDQIFDELLELAEKVKK*" /label="rulR CDS" gene 1645738..1646013 /gene="rulR" /locus_tag="BSU_16610" /old_locus_tag="BSU16610" /label="rulR gene" CDS 1646015..1646317 /gene="rulQ" /locus_tag="BSU_16620" /old_locus_tag="BSU16620" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15130481, 15361074, 22355167, 26522935, 26771646" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15130481, 15361074, 22355167, 26522935, 26771646; Product type f: factor" /codon_start=1 /transl_table=11 /product="K-turn RNA binding protein" /protein_id="NP_389544.1" /db_xref="EnsemblGenomes-Gn:BSU16620" /db_xref="EnsemblGenomes-Tr:CAB13535" /db_xref="GOA:P32729" /db_xref="InterPro:IPR004037" /db_xref="InterPro:IPR004038" /db_xref="InterPro:IPR029064" /db_xref="PDB:3V7Q" /db_xref="SubtiList:BG10267" /db_xref="UniProtKB/Swiss-Prot:P32729" /translation="MSGMEWFPLLGLANRARKVVSGEDLVIKEIRNARAKLVLLTEDA SSNTAKKVTDKCNYYKVPYKKVESRAVLGRSIGKEARVVVAVTDQGFANKLISLLD*" /label="rulQ CDS" gene 1646015..1646317 /gene="rulQ" /locus_tag="BSU_16620" /old_locus_tag="BSU16620" /label="rulQ gene" CDS 1646337..1648487 /gene="infB" /locus_tag="BSU_16630" /old_locus_tag="BSU16630" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1426242, 9588797, 12682299, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1426242, 9588797, 12682299, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="initiation factor IF-2" /protein_id="NP_389545.1" /db_xref="EnsemblGenomes-Gn:BSU16630" /db_xref="EnsemblGenomes-Tr:CAB13536" /db_xref="GOA:P17889" /db_xref="InterPro:IPR000178" /db_xref="InterPro:IPR000795" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR006847" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR015760" /db_xref="InterPro:IPR023115" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036925" /db_xref="SubtiList:BG10268" /db_xref="UniProtKB/Swiss-Prot:P17889" /translation="MAKMRVYEYAKALNVSSKEILTALKNMDLEVNNHMAMLEEKAIK KLDAKYKKGGAAAKSQKPAETNKNKQPQGVNQQSAGNQPNKIRDGKKNDVQNNQFNKN KKNNNNKKNKRNNNNNKNQHQQKPVKPKKELPEKITFSGTLTVGALAEELGKEPSELI KKLMLLGVMATINQELDKDTIELIASEYGVETEEVIVLEETELEKYEEPDNEEDLEIR PPVVTIMGHVDHGKTTLLDSIRKTKVVEGEAGGITQHIGAYQIEENGKKITFLDTPGH AAFTTMRARGAEVTDITILVVAADDGVMPQTVEAINHAKAAEVPIIVAVNKIDKESAN PDRVMQELTEYGLVPEAWGGETIFVPLSALTGKGIDELVEMILLVSEVEELKANPNRQ AKGTVIEAELDKGRGSVATLLVQTGTLHVGDPIVVGNTFGRVRAMVNDIGRRVKTAGP STPVEITGLNDVPQAGDQFLVFKDEKTARSVGEARASKQLEEQRSDKAKLSLDDLFEQ IKQGDVKDINLIVKADVQGSAEALTAALQKIEVEGVKVKIIHTGVGAITESDIILASA SNAIVIGFNVRPDGNAKSTAEAENVDIRLHRIIYKVIDEIEAAMKGMLDPEYEEKVIG QVEVRQTFKVSKIGTIAGGYVTEGTITRDSGLRLIRDGVVIFEGEVDVLKRFKDDVKE VSQGYECGITIKKYNDIREGDILEAFVMQEIERT*" /label="infB CDS" gene 1646337..1648487 /gene="infB" /locus_tag="BSU_16630" /old_locus_tag="BSU16630" /label="infB gene" promotor_-35 1648382..1648388 /Source="Nicolas_upshift_promotors" /id="U1334" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.797202797202797" /psig="0.797202797202797" /xcortree=274 /SigmaFactorBS="aggcgaagtagatgttctgaaacgctttaaagacgatgtgaa agaAGTTTCAcaaggctatgaatgTGGTATTACAATTAAGAAAtacaatgacattcgt g" /listShort="ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1648397 /Source="Nicolas_upshifts" /id="U1334" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.797202797202797" /psig="0.797202797202797" /xcortree=274 /SigmaFactorBS="aggcgaagtagatgttctgaaacgctttaaagacgatgtgaa agaAGTTTCAcaaggctatgaatgTGGTATTACAATTAAGAAAtacaatgacattcgt g" /listShort="ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1648403..1648421 /Source="Nicolas_upshift_promotors" /id="U1334" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.797202797202797" /psig="0.797202797202797" /xcortree=274 /SigmaFactorBS="aggcgaagtagatgttctgaaacgctttaaagacgatgtgaa agaAGTTTCAcaaggctatgaatgTGGTATTACAATTAAGAAAtacaatgacattcgt g" /listShort="ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1648484..1648762 /gene="ylxP" /locus_tag="BSU_16640" /old_locus_tag="BSU16640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="fragment of conserved protein" /db_xref="EnsemblGenomes-Gn:BSU16640" /db_xref="EnsemblGenomes-Tr:CAB13537" /db_xref="InterPro:IPR007546" /db_xref="InterPro:IPR036746" /db_xref="PSEUDO:CAB13537.1" /db_xref="SubtiList:BG10269" /db_xref="UniProtKB/Swiss-Prot:P32730" /translation="MIGFAECECIIYDAGSLKEKRAVLKRILTRVQNKFNVSISEIGY QDTWQRTSFGIAAVSSSRVQTEKELQRVLAFIDSFPEIERTITRTEWF*" /label="ylxP CDS" gene 1648484..1648762 /gene="ylxP" /locus_tag="BSU_16640" /old_locus_tag="BSU16640" /pseudo /label="ylxP gene" CDS 1648779..1649132 /gene="rbfA" /locus_tag="BSU_16650" /old_locus_tag="BSU16650" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12628255, 15185964, 17996707, 21102555, 21529161, 23293003, 23611982, 24671761, 25904134, 27382067; Product type f: factor" /codon_start=1 /transl_table=11 /product="pre-ribosomal (17S) RNA binding factor A" /protein_id="NP_389547.1" /db_xref="EnsemblGenomes-Gn:BSU16650" /db_xref="EnsemblGenomes-Tr:CAB13538" /db_xref="GOA:P32731" /db_xref="InterPro:IPR000238" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR020053" /db_xref="InterPro:IPR023799" /db_xref="SubtiList:BG10270" /db_xref="UniProtKB/Swiss-Prot:P32731" /translation="MSMRANRVGEQMKKELGDIISRKLKDPRIGFLTVTDVRVSGDLQ IAKVYISVLGDEKKREEALKGLAKAKGFIRSEIGSRIRLRKTPEIEFEFDESIDYGNR IETLIHELHSEKPSE*" /label="rbfA CDS" gene 1648779..1649132 /gene="rbfA" /locus_tag="BSU_16650" /old_locus_tag="BSU16650" /label="rbfA gene" downshifts 1649123 /Source="Nicolas_upshifts" /id="D899" /incds=0 /nref=9 /ntot=130 /MaxReadThrough="6.97196" /MaxDrop="5.80207" /score="-3.06560848" /energy="-13.8" /TU="U1331,U1332,U1334" /idTUdmin="U1331" /TUdmin="-308" /isTUend="FALSE" /label="downshifts" CDS 1649214..1650143 /gene="truB" /locus_tag="BSU_16660" /old_locus_tag="BSU16660" /EC_number="5.4.99.25" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7489483, 15987897; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA pseudouridine 55 synthase" /protein_id="NP_389548.1" /db_xref="EnsemblGenomes-Gn:BSU16660" /db_xref="EnsemblGenomes-Tr:CAB13539" /db_xref="GOA:P32732" /db_xref="InterPro:IPR002501" /db_xref="InterPro:IPR014780" /db_xref="InterPro:IPR020103" /db_xref="InterPro:IPR032819" /db_xref="SubtiList:BG10271" /db_xref="UniProtKB/Swiss-Prot:P32732" /translation="MVNGVLLLHKPVGMTSHDCVMKIRKLLKTKKVGHTGTLDPEVSG VLPICVGRATKIVEYLTEKSKTYDAEITLGFSTTTEDQTGETVETKPVNHDIDKADVE KVLNSLKGKQEQIPPMYSAVKVNGKKLYEYARAGIEVERPKRMITIEDIALTTEIKHH GETASFRFTVTCSKGTYVRTLAVMIGEKLGYPAHMSHLIRTASGDFSLDECFTFDELE AQAQSGTVEEHTVPIERALNHLPKWIISDTLAKKVENGALLETPEQFSEMTSGDRIAV FTESGTCLAIYFPHPAKKGLLKPAKVLMQKSEQ*" /label="truB CDS" gene 1649214..1650143 /gene="truB" /locus_tag="BSU_16660" /old_locus_tag="BSU16660" /label="truB gene" promotor_-35 1649928..1649935 /Source="Nicolas_upshift_promotors" /id="U1335" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1975 /SigmaFactorBS="catacagttcctattgaacgtgcgctcaatCATTTGCCgaaa tggatcataAGTGATACATTAGCTAAGAAagtagaaaatggggctttgcttgagacgc c" /listShort="ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1649949..1649968 /Source="Nicolas_upshift_promotors" /id="U1335" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1975 /SigmaFactorBS="catacagttcctattgaacgtgcgctcaatCATTTGCCgaaa tggatcataAGTGATACATTAGCTAAGAAagtagaaaatggggctttgcttgagacgc c" /listShort="ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1649958 /Source="Nicolas_upshifts" /id="U1335" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1975 /SigmaFactorBS="catacagttcctattgaacgtgcgctcaatCATTTGCCgaaa tggatcataAGTGATACATTAGCTAAGAAagtagaaaatggggctttgcttgagacgc c" /listShort="ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /GFF_Attribute="listLong" /label="upshifts" CDS 1650162..1651112 /gene="ribC" /locus_tag="BSU_16670" /old_locus_tag="BSU16670" /EC_number="2.7.1.26" /EC_number="2.7.7.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9473052, 10206712, 12456892, 15668000, 18156273, 21866869" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9473052, 10206712, 12456892, 15668000, 18156273, 21866869; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="bifunctional riboflavin kinase FAD synthase" /protein_id="NP_389549.1" /db_xref="EnsemblGenomes-Gn:BSU16670" /db_xref="EnsemblGenomes-Tr:CAB13540" /db_xref="GOA:P54575" /db_xref="InterPro:IPR002606" /db_xref="InterPro:IPR004821" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR015864" /db_xref="InterPro:IPR015865" /db_xref="InterPro:IPR023465" /db_xref="InterPro:IPR023468" /db_xref="SubtiList:BG11495" /db_xref="UniProtKB/Swiss-Prot:P54575" /translation="MKTIHITHPHHLIKEEQAKSVMALGYFDGVHLGHQKVIGTAKQI AEEKGLTLAVMTFHPHPSHVLGRDKEPKDLITPLEDKINQIEQLGTEVLYVVKFNEVF ASLSPKQFIDQYIIGLNVQHAVAGFDFTYGKYGKGTMKTMPDDLDGKAGCTMVEKLTE QDKKISSSYIRTALQNGDVELANVLLGQPYFIKGIVIHGDKRGRTIGFPTANVGLNNS YIVPPTGVYAVKAEVNGEVYNGVCNIGYKPTFYEKRPEQPSIEVNLFDFNQEVYGAAI KIEWYKRIRSERKFNGIKELTEQIEKDKQEAIRYFSNLRK*" /label="ribC CDS" gene 1650162..1651112 /gene="ribC" /locus_tag="BSU_16670" /old_locus_tag="BSU16670" /label="ribC gene" promotor_-35 1651145..1651151 /Source="Nicolas_upshift_promotors" /id="U1336" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.769230769230769" /psig="0.999000999001" /xcortree=2654 /SigmaFactorBS="ttcagcaatttgcggaaataacttgcaacgcacgcaaatttt attctaaaataTTTGCATataggcacgattttTAGTATGATAGTTTTCGTAGtcttaa a" /listShort="S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1651152..1651268 /Source="Nicolas_S_feature" /locus_tag="new_1738824_1738940" /HighExp="SMM, GM 15, Salt, T-4.40H, GM 45, T-5.40H, GM 60, MG 45, LPhT, MG t5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigB, SigA" /TUshortPSig="0.999, 1, 0.797, 1" /TUlongSig="SigGF, SigA, SigA, SigA, SigGF, SigA, SigD, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.998, 1, 0.773, 1, 0.665, 0.998, 1, 0.998, 1, 0.999, 1, 1, 1" /label="S594" upshifts 1651152 /Source="Nicolas_upshifts" /id="U1336" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.769230769230769" /psig="0.999000999001" /xcortree=2654 /SigmaFactorBS="ttcagcaatttgcggaaataacttgcaacgcacgcaaatttt attctaaaataTTTGCATataggcacgattttTAGTATGATAGTTTTCGTAGtcttaa a" /listShort="S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1651166..1651185 /Source="Nicolas_upshift_promotors" /id="U1336" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.769230769230769" /psig="0.999000999001" /xcortree=2654 /SigmaFactorBS="ttcagcaatttgcggaaataacttgcaacgcacgcaaatttt attctaaaataTTTGCATataggcacgattttTAGTATGATAGTTTTCGTAGtcttaa a" /listShort="S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1651269..1651538 /gene="rpsO" /locus_tag="BSU_16680" /old_locus_tag="BSU16680" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15627386, 8825778, 20418391, 22720735, 23611891" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15627386, 8825778, 20418391, 22720735, 23611891; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S15 (BS18)" /protein_id="NP_389550.1" /db_xref="EnsemblGenomes-Gn:BSU16680" /db_xref="EnsemblGenomes-Tr:CAB13541" /db_xref="GOA:P21473" /db_xref="InterPro:IPR000589" /db_xref="InterPro:IPR005290" /db_xref="InterPro:IPR009068" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19010" /db_xref="UniProtKB/Swiss-Prot:P21473" /translation="MAITQERKNQLINEFKTHESDTGSPEVQIAILTDSINNLNEHLR THKKDHHSRRGLLKMVGKRRNLLTYLRNKDVTRYRELINKLGLRR*" /label="rpsO CDS" gene 1651269..1651538 /gene="rpsO" /locus_tag="BSU_16680" /old_locus_tag="BSU16680" /label="rpsO gene" downshifts 1651521 /Source="Nicolas_upshifts" /id="D900" /incds=0 /nref=30 /ntot=154 /MaxReadThrough="8.65904" /MaxDrop="5.6648" /score="29.9198852" /energy="-10.2" /TU="U1332,U1334,U1335,U1336" /idTUdmin="U1331" /TUdmin=2090 /isTUend="FALSE" /label="downshifts" S_feature 1651566..1651651 /Source="Nicolas_S_feature" /locus_tag="new_1739238_1739323" /HighExp="Cold, LoTm, Oxctl, G180, H2O2, G150, dia15, Paraq, LPh, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigB, SigA" /TUshortPSig="0.999, 1, 0.797, 1" /TUlongSig="SigGF, SigA, SigA, SigA, SigGF, SigA, SigD, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.998, 1, 0.773, 1, 0.665, 0.998, 1, 0.998, 1, 0.999, 1, 1, 1" /label="S595" promotor_-35 1651632..1651635 /Source="Nicolas_upshift_promotors" /id="U1337" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.798201798201798" /psig="0.999000999001" /xcortree=2126 /SigmaFactorBS="ataacaaatcattgaaatccttttacatactactttgacATT GatatgttcaattcatTTCGTTCATAATAGGAGTAAttgattatttcacacaacgaag a" /listShort="pnpA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1651651..1651670 /Source="Nicolas_upshift_promotors" /id="U1337" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.798201798201798" /psig="0.999000999001" /xcortree=2126 /SigmaFactorBS="ataacaaatcattgaaatccttttacatactactttgacATT GatatgttcaattcatTTCGTTCATAATAGGAGTAAttgattatttcacacaacgaag a" /listShort="pnpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1651653 /Source="Nicolas_upshifts" /id="U1337" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.798201798201798" /psig="0.999000999001" /xcortree=2126 /SigmaFactorBS="ataacaaatcattgaaatccttttacatactactttgacATT GatatgttcaattcatTTCGTTCATAATAGGAGTAAttgattatttcacacaacgaag a" /listShort="pnpA" /GFF_Attribute="listLong" /label="upshifts" CDS 1651711..1653828 /gene="pnpA" /locus_tag="BSU_16690" /old_locus_tag="BSU16690" /EC_number="2.7.7.8" /EC_number="3.1.13.1" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8636041, 8825779, 9179491, 10572137, 15805522, 19215769, 19433509, 20659169, 21859751, 22568516, 25099370, 27708634" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8636041, 8825779, 9179491, 10572137, 15805522, 19215769, 19433509, 20659169, 21859751, 22568516, 25099370, 27708634; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="polynucleotide phosphorylase (PNPase)" /protein_id="NP_389551.1" /db_xref="EnsemblGenomes-Gn:BSU16690" /db_xref="EnsemblGenomes-Tr:CAB13542" /db_xref="GOA:P50849" /db_xref="InterPro:IPR001247" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR004087" /db_xref="InterPro:IPR004088" /db_xref="InterPro:IPR012162" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR015847" /db_xref="InterPro:IPR015848" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR022967" /db_xref="InterPro:IPR027408" /db_xref="InterPro:IPR036345" /db_xref="InterPro:IPR036456" /db_xref="InterPro:IPR036612" /db_xref="SubtiList:BG11491" /db_xref="UniProtKB/Swiss-Prot:P50849" /translation="MGQEKHVFTIDWAGRTLTVETGQLAKQANGAVMIRYGDTAVLST ATASKEPKPLDFFPLTVNYEERLYAVGKIPGGFIKREGRPSEKAVLASRLIDRPIRPL FADGFRNEVQVISIVMSVDQNCSSEMAAMFGSSLALSVSDIPFEGPIAGVTVGRIDDQ FIINPTVDQLEKSDINLVVAGTKDAINMVEAGADEVPEEIMLEAIMFGHEEIKRLIAF QEEIVAAVGKEKSEIKLFEIDEELNEKVKALAEEDLLKAIQVHEKHAREDAINEVKNA VVAKFEDEEHDEDTIKQVKQILSKLVKNEVRRLITEEKVRPDGRGVDQIRPLSSEVGL LPRTHGSGLFTRGQTQALSVCTLGALGDVQILDGLGVEESKRFMHHYNFPQFSVGETG PMRGPGRREIGHGALGERALEPVIPSEKDFPYTVRLVSEVLESNGSTSQASICASTLA MMDAGVPIKAPVAGIAMGLVKSGEHYTVLTDIQGMEDALGDMDFKVAGTEKGVTALQM DIKIEGLSREILEEALQQAKKGRMEILNSMLATLSESRKELSRYAPKILTMTINPDKI RDVIGPSGKQINKIIEETGVKIDIEQDGTIFISSTDESGNQKAKKIIEDLVREVEVGQ LYLGKVKRIEKFGAFVEIFSGKDGLVHISELALERVGKVEDVVKIGDEILVKVTEIDK QGRVNLSRKAVLREEKEKEEQQS*" /label="pnpA CDS" gene 1651711..1653828 /gene="pnpA" /locus_tag="BSU_16690" /old_locus_tag="BSU16690" /label="pnpA gene" downshifts 1653611 /Source="Nicolas_upshifts" /id="D901" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="8.05841" /MaxDrop="3.82025" /score="-9.33432702" /energy="-7.8" /TU="U1332,U1334,U1335,U1336,U1337" /idTUdmin="U1337" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" downshifts 1653812 /Source="Nicolas_upshifts" /id="D902" /incds=0 /nref=192 /ntot=270 /MaxReadThrough="5.61214" /MaxDrop="6.82185" /score="-9.33432702" /energy="-7.8" /TU="U1332,U1334,U1335,U1336" /idTUdmin="U1337" /TUdmin=3 /isTUend="TRUE" /label="downshifts" S_feature 1653857..1653945 /Source="Nicolas_S_feature" /locus_tag="new_1741529_1741617" /HighExp="G135, G180, G150, H2O2, Oxctl, LBGexp, Paraq, LoTm, LPh, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigB, SigA" /TUshortPSig="0.999, 1, 0.797, 1" /TUlongSig="SigGF, SigA, SigA, SigA, SigGF, SigA, SigD, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.998, 1, 0.773, 1, 0.665, 0.998, 1, 0.998, 1, 0.999, 1, 1, 1" /label="S596" CDS 1653946..1654905 /gene="ylxY" /locus_tag="BSU_16700" /old_locus_tag="BSU16700" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14679227; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sugar deacetylase" /protein_id="NP_389552.1" /db_xref="EnsemblGenomes-Gn:BSU16700" /db_xref="EnsemblGenomes-Tr:CAB13543" /db_xref="GOA:P50850" /db_xref="InterPro:IPR002509" /db_xref="InterPro:IPR010916" /db_xref="InterPro:IPR011330" /db_xref="InterPro:IPR014228" /db_xref="SubtiList:BG11492" /db_xref="UniProtKB/Swiss-Prot:P50850" /translation="MYKKFVPFAVFLFLFFVSFEMMENPHALDYIGAMKKDTVTVTAS KDPLYEELLQKAPEYEVKPQNARIDKVWKSIPGYNGLKVNIEQSYKKMKQHGKFREKD LVYSQVKPSVHLESLQPEPIYKGNPDKPMVAFLINVAWGNEYLEKMLPILQKHQVKAT FFLEGNWVRNNVQLAKKIAKDGHEIGNHSYNHPDMSKLTTGRISEQLDKTNEQIEQTI GVKPKWFAPPSGSFRKAVIDIAAEKQMGTVMWTVDTIDWQKPAPSVLQTRVLSKIHNG AMILMHPTDPTAESLEALITQIKDKGYALGTVTELMDETRLLK*" /label="ylxY CDS" gene 1653946..1654905 /gene="ylxY" /locus_tag="BSU_16700" /old_locus_tag="BSU16700" /label="ylxY gene" promotor_-10 complement(1654014..1654022) /Source="Nicolas_upshift_promotors" /id="U1338" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.645354645354645" /psig="0.645354645354645" /xcortree=686 /SigmaFactorBS="tgacgccgtgacagtcaccgtatcttttttcattGCCCCTAT ataatcaagtgcaTGCGGATTTtccatcatctcaaatgagacaaaaaaaagaaataaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1654017) /Source="Nicolas_upshifts" /id="U1338" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.645354645354645" /psig="0.645354645354645" /xcortree=686 /SigmaFactorBS="tgacgccgtgacagtcaccgtatcttttttcattGCCCCTAT ataatcaagtgcaTGCGGATTTtccatcatctcaaatgagacaaaaaaaagaaataaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1654036..1654043) /Source="Nicolas_upshift_promotors" /id="U1338" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.645354645354645" /psig="0.645354645354645" /xcortree=686 /SigmaFactorBS="tgacgccgtgacagtcaccgtatcttttttcattGCCCCTAT ataatcaagtgcaTGCGGATTTtccatcatctcaaatgagacaaaaaaaagaaataaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1654509..1654514 /Source="Nicolas_upshift_promotors" /id="U1339" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.644355644355644" /psig="0.644355644355644" /xcortree=1044 /SigmaFactorBS="agattgcaaaagacggacatgaaatcggaaatcaTTCATAca atcatccggatatGAGCAAACTGACTACAGGAagaatttccgagcagctcgacaagac t" /listShort="mlpA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1654530..1654548 /Source="Nicolas_upshift_promotors" /id="U1339" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.644355644355644" /psig="0.644355644355644" /xcortree=1044 /SigmaFactorBS="agattgcaaaagacggacatgaaatcggaaatcaTTCATAca atcatccggatatGAGCAAACTGACTACAGGAagaatttccgagcagctcgacaagac t" /listShort="mlpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1654535 /Source="Nicolas_upshifts" /id="U1339" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.644355644355644" /psig="0.644355644355644" /xcortree=1044 /SigmaFactorBS="agattgcaaaagacggacatgaaatcggaaatcaTTCATAca atcatccggatatGAGCAAACTGACTACAGGAagaatttccgagcagctcgacaagac t" /listShort="mlpA" /GFF_Attribute="listLong" /label="upshifts" CDS 1654945..1656174 /gene="mlpA" /locus_tag="BSU_16710" /old_locus_tag="BSU16710" /EC_number="3.4.24.-" /function="16.6: Maintain" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10666719, 10974125" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10666719, 10974125; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="specific processing protease" /protein_id="NP_389553.2" /db_xref="EnsemblGenomes-Gn:BSU16710" /db_xref="EnsemblGenomes-Tr:CAB13544" /db_xref="GOA:Q04805" /db_xref="InterPro:IPR001431" /db_xref="InterPro:IPR007863" /db_xref="InterPro:IPR011249" /db_xref="InterPro:IPR011765" /db_xref="SubtiList:BG10779" /db_xref="UniProtKB/Swiss-Prot:Q04805" /translation="MIKRYTCQNGVRIVLENNPTVRSVAIGVWIGTGSRHETPEINGI SHFLEHMFFKGTSTKSAREIAESFDRIGGQVNAFTSKEYTCYYAKVLDEHANYALDVL ADMFFHSTFDENELKKEKNVVYEEIKMYEDAPDDIVHDLLSKATYGNHSLGYPILGTE ETLASFNGDSLRQYMHDYYTPDRVVISVAGNISDSFIKDVEKWFGSYEAKGKATGLEK PEFHTEKLTRKKETEQAHLCLGFKGLEVGHERIYDLIVLNNVLGGSMSSRLFQDVRED KGLAYSVYSYHSSYEDSGMLTIYGGTGANQLQQLSETIQETLATLKRDGITSKELENS KEQMKGSLMLSLESTNSKMSRNGKNELLLGKHKTLDEIINELNAVNLERVNGLARQLF TEDYALALISPSGNMPS*" /label="mlpA CDS" gene 1654945..1656174 /gene="mlpA" /locus_tag="BSU_16710" /old_locus_tag="BSU16710" /label="mlpA gene" downshifts 1656163 /Source="Nicolas_upshifts" /id="D903" /incds=0 /nref=140 /ntot=219 /MaxReadThrough="1.31218" /MaxDrop="4.84427" /score="15.1952611" /energy="-12.6" /TU="NA" /idTUdmin="U1336" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1656203..1656208 /Source="Nicolas_upshift_promotors" /id="U1340" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1150 /SigmaFactorBS="gcaatatgccgtcttaaaaaggaaagcctgccccataatgga gcaGGCATTttttaatccctttcaTCATACATAGTACAAGGGGgtgacagacatgcgg c" /listShort="ymxH" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1656218 /Source="Nicolas_upshifts" /id="U1340" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1150 /SigmaFactorBS="gcaatatgccgtcttaaaaaggaaagcctgccccataatgga gcaGGCATTttttaatccctttcaTCATACATAGTACAAGGGGgtgacagacatgcgg c" /listShort="ymxH" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1656224..1656242 /Source="Nicolas_upshift_promotors" /id="U1340" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1150 /SigmaFactorBS="gcaatatgccgtcttaaaaaggaaagcctgccccataatgga gcaGGCATTttttaatccctttcaTCATACATAGTACAAGGGGgtgacagacatgcgg c" /listShort="ymxH" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1656252..1656509 /gene="ymxH" /locus_tag="BSU_16720" /old_locus_tag="BSU16720" /experiment="publication(s) with functional evidences, PMID:23396918" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23396918; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="PRC barrel protein involved in sporulation" /protein_id="NP_389554.1" /db_xref="EnsemblGenomes-Gn:BSU16720" /db_xref="EnsemblGenomes-Tr:CAB13545" /db_xref="GOA:Q04811" /db_xref="InterPro:IPR011033" /db_xref="InterPro:IPR014238" /db_xref="InterPro:IPR027275" /db_xref="SubtiList:BG10780" /db_xref="UniProtKB/Swiss-Prot:Q04811" /translation="MRLSELSGKEIVDIKRAERLGVLGQTDLEINEQDGQITALLIPT VKWFGLRKQGHDIRVPWHHIQKIGSDMIILDVPEEMPPRQE*" /label="ymxH CDS" gene 1656252..1656509 /gene="ymxH" /locus_tag="BSU_16720" /old_locus_tag="BSU16720" /label="ymxH gene" S_feature 1656510..1656564 /Source="Nicolas_S_feature" /locus_tag="new_1744182_1744236" /HighExp="S4, S3, S5, S6, S8, S7, B36, BT, LoTm, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S597" downshifts 1656537 /Source="Nicolas_upshifts" /id="D904" /incds=0 /nref=41 /ntot=56 /MaxReadThrough="0.534319999999999" /MaxDrop="6.36032" /score="29.434739" /energy="-11.7" /TU="NA" /idTUdmin="U1340" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1656606..1656615 /Source="Nicolas_upshift_promotors" /id="U1341" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1299 /SigmaFactorBS="ccggagccgatgtttttttatatggaaaaagcgcatcttttA TATTCACCGgtatttccttttgATCATAAGATGAAGGGGAGCttaacaactagagatc c" /listShort="S598, spoVFA, spoVFB, S599, asd, S600, dapG, dapA" /listLong="rnjB" /label="promotor_-35" S_feature 1656625..1656694 /Source="Nicolas_S_feature" /locus_tag="new_1744297_1744366" /HighExp="S6, S8, S7, BT, B36, S5, G/S, Pyr, B60, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S598" upshifts 1656625 /Source="Nicolas_upshifts" /id="U1341" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1299 /SigmaFactorBS="ccggagccgatgtttttttatatggaaaaagcgcatcttttA TATTCACCGgtatttccttttgATCATAAGATGAAGGGGAGCttaacaactagagatc c" /listShort="S598, spoVFA, spoVFB, S599, asd, S600, dapG, dapA" /listLong="rnjB" /label="upshifts" promotor_-10 1656629..1656648 /Source="Nicolas_upshift_promotors" /id="U1341" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1299 /SigmaFactorBS="ccggagccgatgtttttttatatggaaaaagcgcatcttttA TATTCACCGgtatttccttttgATCATAAGATGAAGGGGAGCttaacaactagagatc c" /listShort="S598, spoVFA, spoVFB, S599, asd, S600, dapG, dapA" /listLong="rnjB" /label="promotor_-10" CDS 1656695..1657588 /gene="spoVFA" /locus_tag="BSU_16730" /old_locus_tag="BSU16730" /EC_number="1.3.1.-" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8098035, 8345520, 16707666, 25402593" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8098035, 8345520, 16707666, 25402593; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore dipicolinate synthase subunit A" /protein_id="NP_389555.1" /db_xref="EnsemblGenomes-Gn:BSU16730" /db_xref="EnsemblGenomes-Tr:CAB13546" /db_xref="GOA:Q04809" /db_xref="InterPro:IPR007698" /db_xref="InterPro:IPR014215" /db_xref="InterPro:IPR031629" /db_xref="InterPro:IPR036291" /db_xref="PDB:2RIR" /db_xref="SubtiList:BG10781" /db_xref="UniProtKB/Swiss-Prot:Q04809" /translation="MLTGLKIAVIGGDARQLEIIRKLTEQQADIYLVGFDQLDHGFTG AVKCNIDEIPFQQIDSIILPVSATTGEGVVSTVFSNEEVVLKQDHLDRTPAHCVIFSG ISNAYLENIAAQAKRKLVKLFERDDIAIYNSIPTVEGTIMLAIQHTDYTIHGSQVAVL GLGRTGMTIARTFAALGANVKVGARSSAHLARITEMGLVPFHTDELKEHVKDIDICIN TIPSMILNQTVLSSMTPKTLILDLASRPGGTDFKYAEKQGIKALLAPGLPGIVAPKTA GQILANVLSKLLAEIQAEEGK*" /label="spoVFA CDS" gene 1656695..1657588 /gene="spoVFA" /locus_tag="BSU_16730" /old_locus_tag="BSU16730" /label="spoVFA gene" CDS 1657591..1658193 /gene="spoVFB" /locus_tag="BSU_16740" /old_locus_tag="BSU16740" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8098035, 8345520, 16707666, 25402593" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8098035, 8345520, 16707666, 25402593; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore dipicolinate synthase subunit B" /protein_id="NP_389556.1" /db_xref="EnsemblGenomes-Gn:BSU16740" /db_xref="EnsemblGenomes-Tr:CAB13547" /db_xref="GOA:Q04810" /db_xref="InterPro:IPR003382" /db_xref="InterPro:IPR014214" /db_xref="InterPro:IPR036551" /db_xref="SubtiList:BG10782" /db_xref="UniProtKB/Swiss-Prot:Q04810" /translation="MSSLKGKRIGFGLTGSHCTYEAVFPQIEELVNEGAEVRPVVTFN VKSTNTRFGEGAEWVKKIEDLTGYEAIDSIVKAEPLGPKLPLDCMVIAPLTGNSMSKL ANAMTDSPVLMAAKATIRNNRPVVLGISTNDALGLNGTNLMRLMSTKNIFFIPFGQDD PFKKPNSMVAKMDLLPQTIEKALMHQQLQPILVENYQGND*" /label="spoVFB CDS" gene 1657591..1658193 /gene="spoVFB" /locus_tag="BSU_16740" /old_locus_tag="BSU16740" /label="spoVFB gene" misc_feature 1658247..1658266 /Source="Nicolas_upshift_promotors" /id="U1342" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig="0.781218781218781" /xcortree=1233 /SigmaFactorBS="tgactaaatttacagaaaatctttcccaaactaaaaaattcg gtcatcacccgcatattcTATGGTAAAATAAAACGTAAaatcatagtcaaatcaattc a" /listShort="S599, asd, S600, dapG, dapA, rnjB, tepA, ylzJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1658247..1658318 /Source="Nicolas_S_feature" /locus_tag="new_1745919_1745990" /HighExp="S6, S7, S8, C90, S5, BT, MG 45, MG 5, SMM, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.781, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S599" upshifts 1658247 /Source="Nicolas_upshifts" /id="U1342" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig="0.781218781218781" /xcortree=1233 /SigmaFactorBS="tgactaaatttacagaaaatctttcccaaactaaaaaattcg gtcatcacccgcatattcTATGGTAAAATAAAACGTAAaatcatagtcaaatcaattc a" /listShort="S599, asd, S600, dapG, dapA, rnjB, tepA, ylzJ" /GFF_Attribute="listLong" /label="upshifts" CDS 1658319..1659359 /gene="asd" /locus_tag="BSU_16750" /old_locus_tag="BSU16750" /EC_number="1.2.1.11" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8098035, 12682299, 25355936, 25393291" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8098035, 12682299, 25355936, 25393291; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aspartate-semialdehyde dehydrogenase" /protein_id="NP_389557.1" /db_xref="EnsemblGenomes-Gn:BSU16750" /db_xref="EnsemblGenomes-Tr:CAB13548" /db_xref="GOA:Q04797" /db_xref="InterPro:IPR000319" /db_xref="InterPro:IPR000534" /db_xref="InterPro:IPR005986" /db_xref="InterPro:IPR012080" /db_xref="InterPro:IPR012280" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10783" /db_xref="UniProtKB/Swiss-Prot:Q04797" /translation="MGRGLHVAVVGATGAVGQQMLKTLEDRNFEMDTLTLLSSKRSAG TKVTFKGQELTVQEASPESFEGVNIALFSAGGSVSQALAPEAVKRGAIVIDNTSAFRM DENTPLVVPEVNEADLHEHNGIIANPNCSTIQMVAALEPIRKAYGLNKVIVSTYQAVS GAGNEAVKELYSQTQAILNKEEIEPEIMPVKGDKKHYQIAFNAIPQIDKFQDNGYTFE EMKMINETKKIMHMPDLQVAATCVRLPIQTGHSESVYIEIDRDDATVEDIKNLLKEAP GVTLQDDPSQQLYPMPADAVGKNDVFVGRIRKDLDRANGFHLWVVSDNLLKGAAWNSV QIAESLKKLNLV*" /label="asd CDS" gene 1658319..1659359 /gene="asd" /locus_tag="BSU_16750" /old_locus_tag="BSU16750" /label="asd gene" S_feature 1659360..1659450 /Source="Nicolas_S_feature" /locus_tag="new_1747032_1747122" /HighExp="S7, S6, S8, LBGtran, GM 120, dia15, Heat, LBGstat, GM 90, MG 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.781, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S600" CDS 1659451..1660665 /gene="dapG" /locus_tag="BSU_16760" /old_locus_tag="BSU16760" /EC_number="2.7.2.4" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:1906928, 8098035" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1906928, 8098035; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aspartokinase I (alpha and beta subunits)" /protein_id="NP_389558.2" /db_xref="EnsemblGenomes-Gn:BSU16760" /db_xref="EnsemblGenomes-Tr:CAB13549" /db_xref="GOA:Q04795" /db_xref="InterPro:IPR001048" /db_xref="InterPro:IPR001341" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR005260" /db_xref="InterPro:IPR018042" /db_xref="InterPro:IPR027795" /db_xref="InterPro:IPR036393" /db_xref="SubtiList:BG10784" /db_xref="UniProtKB/Swiss-Prot:Q04795" /translation="MKIIVQKFGGTSVKDDKGRKLALGHIKEAISEGYKVVVVVSAMG RKGDPYATDSLLGLLYGDQSAISPREQDLLLSCGETISSVVFTSMLLDNGVKAAALTG AQAGFLTNDQHTNAKIIEMKPERLFSVLANHDAVVVAGFQGATEKGDTTTIGRGGSDT SAAALGAAVDAEYIDIFTDVEGVMTADPRVVENAKPLPVVTYTEICNLAYQGAKVISP RAVEIAMQAKVPIRVRSTYSNDKGTLVTSHHSSKVGSDVFERLITGIAHVKDVTQFKV PAKIGQYNVQTEVFKAMANAGISVDFFNITPSEIVYTVAGNKTETAQRILMDMGYDPM VTRNCAKVSAVGAGIMGVPGVTSKIVSALSEKEIPILQSADSHTTIWVLVHEADMVPA VNALHEVFELSK*" /label="dapG CDS" gene 1659451..1660665 /gene="dapG" /locus_tag="BSU_16760" /old_locus_tag="BSU16760" /label="dapG gene" CDS 1660696..1661568 /gene="dapA" /locus_tag="BSU_16770" /old_locus_tag="BSU16770" /EC_number="4.3.3.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8098035, 9298659" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8098035, 9298659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-hydroxy-tetrahydrodipicolinate synthase" /protein_id="NP_389559.1" /db_xref="EnsemblGenomes-Gn:BSU16770" /db_xref="EnsemblGenomes-Tr:CAB13550" /db_xref="GOA:Q04796" /db_xref="InterPro:IPR002220" /db_xref="InterPro:IPR005263" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR020624" /db_xref="InterPro:IPR020625" /db_xref="SubtiList:BG10785" /db_xref="UniProtKB/Swiss-Prot:Q04796" /translation="MNFGNVSTAMITPFDNKGNVDFQKLSTLIDYLLKNGTDSLVVAG TTGESPTLSTEEKIALFEYTVKEVNGRVPVIAGTGSNNTKDSIKLTKKAEEAGVDAVM LVTPYYNKPSQEGMYQHFKAIAAETSLPVMLYNVPGRTVASLAPETTIRLAADIPNVV AIKEASGDLEAITKIIAETPEDFYVYSGDDALTLPILSVGGRGVVSVASHIAGTDMQQ MIKNYTNGQTANAALIHQKLLPIMKELFKAPNPAPVKTALQLRGLDVGSVRLPLVPLT EDERLSLSSTISEL*" /label="dapA CDS" gene 1660696..1661568 /gene="dapA" /locus_tag="BSU_16770" /old_locus_tag="BSU16770" /label="dapA gene" S_feature complement(1661039..1662223) /Source="Nicolas_S_feature" /locus_tag="new_1748711_1749895_c" /HighExp="S8, S6, S4, S5, S7, S3, LoTm, T5.0H, BT, C30" /AntisenseName="dapA" /AntisenseCor="0.13444126275526899" /AntisenseRegPval="-1.6" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S601" downshifts 1661575 /Source="Nicolas_upshifts" /id="D905" /incds=0 /nref=17 /ntot=99 /MaxReadThrough="6.0497" /MaxDrop="5.05122" /score="24.080775" /energy="-11.7" /TU="U1342" /idTUdmin="U1341" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1661668..1661671 /Source="Nicolas_upshift_promotors" /id="U1343" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.862137862137862" /psig=1 /xcortree=2241 /SigmaFactorBS="cgtttcttttacatattggttttccctaaaccttctgcttta tCTTGttttctaaatttactTTCAGTTATAATAGGAACAAgtgatgatggacgggtat g" /listShort="rnjB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1661685 /Source="Nicolas_upshifts" /id="U1343" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.862137862137862" /psig=1 /xcortree=2241 /SigmaFactorBS="cgtttcttttacatattggttttccctaaaccttctgcttta tCTTGttttctaaatttactTTCAGTTATAATAGGAACAAgtgatgatggacgggtat g" /listShort="rnjB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1661687..1661706 /Source="Nicolas_upshift_promotors" /id="U1343" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.862137862137862" /psig=1 /xcortree=2241 /SigmaFactorBS="cgtttcttttacatattggttttccctaaaccttctgcttta tCTTGttttctaaatttactTTCAGTTATAATAGGAACAAgtgatgatggacgggtat g" /listShort="rnjB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1661746..1663413 /gene="rnjB" /locus_tag="BSU_16780" /old_locus_tag="BSU16780" /EC_number="3.1.-.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15831787, 18713320, 20025672, 20729365, 24187087, 26296725, 28384222" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15831787, 18713320, 20025672, 20729365, 24187087, 26296725, 28384222; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dual activity 5' exo-and endoribonuclease J2" /protein_id="NP_389560.2" /db_xref="EnsemblGenomes-Gn:BSU16780" /db_xref="EnsemblGenomes-Tr:CAB13551" /db_xref="GOA:O31760" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR004613" /db_xref="InterPro:IPR011108" /db_xref="InterPro:IPR030854" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG13422" /db_xref="UniProtKB/Swiss-Prot:O31760" /translation="MKKKNTENVRIIALGGVGEIGKNLYVIEIDSDIFVVDAGLMHPE NEMLGIDVVIPDISYLIERADRVKAIFLTHGHDENIGGVFYLLNKLSVPVYGTKLTLA LLREKLKQYGHNRKTDLREIHSKSVITFESTKVSFFRTIHSIPDSVGVSFKTSLGSIV CTGDFKFDQTPALNQTCDIGEIAKIGNSGVLALLSDSANAERPGYTPSEAAVSGEISD ALYNSQNRVIIAVFASNINRIQQVIHAAAQNGRKIAVAGKNLQSVLQLARKLGYIEAD DELFISVQDVKKYPKREVAIITAGSQGEPLAALTRMANKAHKQLNIEEGDTVVIASTP IPGQELIYSKTVDLLARAGAQVIFAQKRVHVSGHGSQEELKLMINLLKPKYLIPVNGE YRMQKAHSKIAEETGMKRSDIFLIEKGDVVEFRGQNVKIGDKVPYGNILIDGLGVGDI GNIVLRDRRLLSQDGILIVVITLDKQKKHLVSGPEIITRGFVYVRESEGLIVQATELV RSIVTEATETSNVEWSTLKQAMRDALNQFLYEKTKRKPMIIPIIMEV*" /label="rnjB CDS" gene 1661746..1663413 /gene="rnjB" /locus_tag="BSU_16780" /old_locus_tag="BSU16780" /label="rnjB gene" promotor_-10 complement(1662210..1662228) /Source="Nicolas_upshift_promotors" /id="U1344" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1085 /SigmaFactorBS="tcgccaatgtcgcacgtctgattaagtgcaggtgtttgGTCA AAtttgaagtctcccgtGCATACAATAGATCCAAGTgatgttttaaagctcacaccta c" /listShort="S601" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1662227) /Source="Nicolas_upshifts" /id="U1344" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1085 /SigmaFactorBS="tcgccaatgtcgcacgtctgattaagtgcaggtgtttgGTCA AAtttgaagtctcccgtGCATACAATAGATCCAAGTgatgttttaaagctcacaccta c" /listShort="S601" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1662244..1662249) /Source="Nicolas_upshift_promotors" /id="U1344" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1085 /SigmaFactorBS="tcgccaatgtcgcacgtctgattaagtgcaggtgtttgGTCA AAtttgaagtctcccgtGCATACAATAGATCCAAGTgatgttttaaagctcacaccta c" /listShort="S601" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1663401 /Source="Nicolas_upshifts" /id="D906" /incds=0 /nref=227 /ntot=263 /MaxReadThrough="4.0072" /MaxDrop="6.75416" /score="24.080775" /energy="-11.7" /TU="U1342" /idTUdmin="U1343" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1663468..1663474 /Source="Nicolas_upshift_promotors" /id="U1345" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=917 /SigmaFactorBS="cggagctgctccggtctttattttttgtccttcaagccgGGA TTGAatgaagtatctttGTTCATAATACAaagagaaactcggaaaggatgaaagcgag a" /listShort="tepA, ylzJ, spoIIIE, S602" /listLong="ymfC" /label="promotor_-35" promotor_-10 1663488..1663499 /Source="Nicolas_upshift_promotors" /id="U1345" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=917 /SigmaFactorBS="cggagctgctccggtctttattttttgtccttcaagccgGGA TTGAatgaagtatctttGTTCATAATACAaagagaaactcggaaaggatgaaagcgag a" /listShort="tepA, ylzJ, spoIIIE, S602" /listLong="ymfC" /label="promotor_-10" upshifts 1663489 /Source="Nicolas_upshifts" /id="U1345" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=917 /SigmaFactorBS="cggagctgctccggtctttattttttgtccttcaagccgGGA TTGAatgaagtatctttGTTCATAATACAaagagaaactcggaaaggatgaaagcgag a" /listShort="tepA, ylzJ, spoIIIE, S602" /listLong="ymfC" /label="upshifts" CDS 1663529..1664266 /gene="tepA" /locus_tag="BSU_16790" /old_locus_tag="BSU16790" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10455123, 15189290, 23927687" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10455123, 15189290, 23927687; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein export-enhancing protease (spore outgrowth)" /protein_id="NP_389561.3" /db_xref="EnsemblGenomes-Gn:BSU16790" /db_xref="EnsemblGenomes-Tr:CAB13552" /db_xref="GOA:Q99171" /db_xref="InterPro:IPR023562" /db_xref="InterPro:IPR029045" /db_xref="SubtiList:BG11055" /db_xref="UniProtKB/Swiss-Prot:Q99171" /translation="MDHRMENTEEERPEKNDAKDSIMNKIQQLGETTLPQLPQDTNIH CLTIIGQIEGHVQLPPQNKTTKYEHVIPQIVAIEQNPKIEGLLIILNTVGGDVEAGLA IAEMLASLSKPTVSIVLGGGHSIGVPIAVSCDYSYIAETATMTIHPVRLTGLVIGVPQ TFEYLDKMQERVVKFVTSHSNITEEKFKELMFSKGNLTRDIGTNVVGKDAVKYGLIDH AGGVGQAINKLNELIDEARKEEGRMIQ*" /label="tepA CDS" gene 1663529..1664266 /gene="tepA" /locus_tag="BSU_16790" /old_locus_tag="BSU16790" /label="tepA gene" CDS 1664263..1664475 /gene="tepJ" /locus_tag="BSU_16799" /old_locus_tag="BSU16799" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:23927687" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23927687; Product type r: regulator" /codon_start=1 /transl_table=11 /product="modulator of TepA activity (spore outgrowth)" /protein_id="YP_003097729.1" /db_xref="EnsemblGenomes-Gn:BSU16799" /db_xref="EnsemblGenomes-Tr:CAX52620" /db_xref="InterPro:IPR025619" /db_xref="UniProtKB/Swiss-Prot:C0H413" /translation="MILYTVMPQEIVFAEQNQETSAHEQIEYKGVPLLVEMKGNEAEV IQIMSTNPMHFLHPDISPGQKLKLNV*" /label="tepJ CDS" gene 1664263..1664475 /gene="tepJ" /locus_tag="BSU_16799" /old_locus_tag="BSU16799" /label="tepJ gene" misc_feature 1664503..1664522 /Source="Nicolas_upshift_promotors" /id="U1346" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.997002997002997" /psig="0.999000999001" /xcortree=2128 /SigmaFactorBS="gctgaaattaaacgtataagaatccaacccttttttaagggc aaaaTATGCTATAATAGGGGAATCctacagaaaaaacgcagcctgtaaacggctgctt t" /listShort="spoIIIE, S602, ymfC" /listLong="ymfD" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1664517 /Source="Nicolas_upshifts" /id="U1346" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.997002997002997" /psig="0.999000999001" /xcortree=2128 /SigmaFactorBS="gctgaaattaaacgtataagaatccaacccttttttaagggc aaaaTATGCTATAATAGGGGAATCctacagaaaaaacgcagcctgtaaacggctgctt t" /listShort="spoIIIE, S602, ymfC" /listLong="ymfD" /label="upshifts" CDS 1664606..1666969 /gene="spoIIIE" /locus_tag="BSU_16800" /old_locus_tag="BSU16800" /function="16.13: Shape" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11062134, 11778051, 12618465, 16430687, 17139259, 17322320, 18160039, 24297254, 24769697, 26452092; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore DNA directional translocase (motor ATPase)" /protein_id="NP_389562.3" /db_xref="EnsemblGenomes-Gn:BSU16800" /db_xref="EnsemblGenomes-Tr:CAB13553" /db_xref="GOA:P21458" /db_xref="InterPro:IPR002543" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR018541" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10763" /db_xref="UniProtKB/Swiss-Prot:P21458" /translation="MAKKKRKSRKKQAKQLNIKYELNGLLCIAISIIAILQLGVVGQT FIYLFRFFAGEWFILCLLGLLVLGVSLFWKKKTPSLLTRRKAGLYCIIASILLLSHVQ LFKNLTHKGSIESASVVRNTWELFLMDMNGSSASPDLGGGMIGALLFAASHFLFASTG SQIMAIVMILIGMILVTGRSLQETLKKWMSPIGRFIKEQWLAFIDDMKSFKSNMQSSK KTKAPSKKQKPARKKQQMEPEPPDEEGDYETVSPLIHSEPIISSFSDRNEEEESPVIE KRAEPVSKPLQDIQPETGDQETVSAPPMTFTELENKDYEMPSLDLLADPKHTGQQADK KNIYENARKLERTFQSFGVKAKVTQVHLGPAVTKYEVYPDVGVKVSKIVNLSDDLALA LAAKDIRIEAPIPGKSAIGIEVPNAEVAMVSLKEVLESKLNDRPDAKLLIGLGRNISG EAVLAELNKMPHLLVAGATGSGKSVCVNGIITSILMRAKPHEVKMMMIDPKMVELNVY NGIPHLLAPVVTDPKKASQALKKVVNEMERRYELFSHTGTRNIEGYNDYIKRANNEEG AKQPELPYIVVIVDELADLMMVASSDVEDSITRLSQMARAAGIHLIIATQRPSVDVIT GVIKANIPSRIAFSVSSQTDSRTILDMGGAEKLLGRGDMLFLPVGANKPVRVQGAFLS DDEVEKVVDHVITQQKAQYQEEMIPEETTETHSEVTDELYDEAVELIVGMQTASVSML QRRFRIGYTRAARLIDAMEERGVVGPYEGSKPREVLLSKEKYDELSS*" /label="spoIIIE CDS" gene 1664606..1666969 /gene="spoIIIE" /locus_tag="BSU_16800" /old_locus_tag="BSU16800" /label="spoIIIE gene" S_feature 1666970..1667070 /Source="Nicolas_S_feature" /locus_tag="new_1754642_1754742" /HighExp="Cold, C30, G135, Lbstat, BC, G180, G150, S8, LoTm, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.109246" /TUshortSig="SigA, SigGF" /TUshortPSig="0.999, 0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S602" promotor_-35 1667031..1667038 /Source="Nicolas_upshift_promotors" /id="U1347" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.742257742257742" /psig="0.98901098901099" /xcortree=3004 /SigmaFactorBS="atgtaaactgatcacctttcTATTTATTttttcgacaaaaca TGATATAGTTGTCCCAATTGttcaataatttttatcgaaagtggtttacggaggggaa a" /listShort="ymfC, ymfD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1667053..1667072 /Source="Nicolas_upshift_promotors" /id="U1347" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.742257742257742" /psig="0.98901098901099" /xcortree=3004 /SigmaFactorBS="atgtaaactgatcacctttcTATTTATTttttcgacaaaaca TGATATAGTTGTCCCAATTGttcaataatttttatcgaaagtggtttacggaggggaa a" /listShort="ymfC, ymfD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1667071 /Source="Nicolas_upshifts" /id="U1347" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.742257742257742" /psig="0.98901098901099" /xcortree=3004 /SigmaFactorBS="atgtaaactgatcacctttcTATTTATTttttcgacaaaaca TGATATAGTTGTCCCAATTGttcaataatttttatcgaaagtggtttacggaggggaa a" /listShort="ymfC, ymfD" /GFF_Attribute="listLong" /label="upshifts" CDS 1667113..1667838 /gene="ymfC" /locus_tag="BSU_16810" /old_locus_tag="BSU16810" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (GntR family,possibly involved in biofilm formation)" /protein_id="NP_389563.1" /db_xref="EnsemblGenomes-Gn:BSU16810" /db_xref="EnsemblGenomes-Tr:CAB13554" /db_xref="GOA:O31761" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR011663" /db_xref="InterPro:IPR028978" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13423" /db_xref="UniProtKB/Swiss-Prot:O31761" /translation="MSTKADNRHLYLKVIERIKEDIKNGIYTEKEKLPSEFELSKKLG VSRATLREALRILEEEHVIIRRHGVGTFVHSKPLFLSGIEQLNSVTKMIEQANMTPGT IFLSSQVLMPSEDDTKRFHLAEGQELFYLERVRTADGQPIVYCIDKIPMNILPNSFSH QQESMFDLLEKNSGSVISYAVTDIEPIGYHDTISPVLECDPETALLLLKQTHYDQHDK PVLYSLNYFRADKFRFHVLRKRF*" /label="ymfC CDS" gene 1667113..1667838 /gene="ymfC" /locus_tag="BSU_16810" /old_locus_tag="BSU16810" /label="ymfC gene" downshifts 1667825 /Source="Nicolas_upshifts" /id="D907" /incds=0 /nref=135 /ntot=256 /MaxReadThrough="4.863" /MaxDrop="4.01593" /score="16.3235883" /energy="-7.2" /TU="U1346,U1347" /idTUdmin="U1346" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" promotor_-35 1667894..1667900 /Source="Nicolas_upshift_promotors" /id="U1348" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=912 /SigmaFactorBS="atgtgtctgtttttttatttgcactgattcatgtttctttgT ACATACtttcattccggttaACGCAATATATAagggatgacaagaaagtgaatgggtg a" /listShort="ymfD" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1667913 /Source="Nicolas_upshifts" /id="U1348" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=912 /SigmaFactorBS="atgtgtctgtttttttatttgcactgattcatgtttctttgT ACATACtttcattccggttaACGCAATATATAagggatgacaagaaagtgaatgggtg a" /listShort="ymfD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1667915..1667926 /Source="Nicolas_upshift_promotors" /id="U1348" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=912 /SigmaFactorBS="atgtgtctgtttttttatttgcactgattcatgtttctttgT ACATACtttcattccggttaACGCAATATATAagggatgacaagaaagtgaatgggtg a" /listShort="ymfD" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1667977..1669185 /gene="bcbE" /locus_tag="BSU_16825" /old_locus_tag="BSU16825" /function="7: Transport and binding proteins" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 18502870, 27375568" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 18502870, 27375568; Product type t: transporter" /codon_start=1 /transl_table=11 /product="bacillibactin exporter" /protein_id="NP_389564.2" /db_xref="EnsemblGenomes-Gn:BSU16825" /db_xref="EnsemblGenomes-Tr:CAB13555" /db_xref="GOA:O31762" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13424" /db_xref="UniProtKB/Swiss-Prot:O31762" /translation="MKNIIALSSVPLVMTLGNSMLIPVLPMMEKKLSVTSFQVSLIIT VYSVVAIICIPIAGYLSDRFGRKKILLPCLLIAGLGGAVAAFASTYMKNPYAMILAGR VLQGIGSAGAAPIVMPFIGDLFKGDDEKVSAGLGDIETANTSGKVLSPILGALLASWY WFVPFWFIPFFCLISFLLVLFLVAKPEEDEDAPAVSEFIKSVKKIFKQDGRWLYTVFI IGCVIMFLLFGVLFYLSDTLENKYAIDGVAKGGLLAIPLLFLSTSSFIAGKKIGKDKG RMKFCVVTGMILLTLSFIALWWNHSFYFLFVFLSFGGIGIGMALPALDALITEGIESE QCGTISSFYNSMRFIGVALGPPVFAALMSNANWIIFILSAFCSIVSLFLVLFTVDAKK SEEEKNLGTV*" /label="bcbE CDS" gene 1667977..1669185 /gene="bcbE" /locus_tag="BSU_16825" /old_locus_tag="BSU16825" /label="bcbE gene" downshifts 1669143 /Source="Nicolas_upshifts" /id="D908" /incds=0 /nref=1 /ntot=32 /MaxReadThrough="1.34389" /MaxDrop="3.00655" /score="5.64651968" /energy="-6.7" /TU="NA" /idTUdmin="U1348" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1669254..1669261 /Source="Nicolas_upshift_promotors" /id="U1349" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5994005994006" /psig="0.987012987012987" /xcortree=1918 /SigmaFactorBS="cagcatgcggaggttattGTTTCCTTataaatcctacaGTTG CTATAATTACATGAAAgagtgtttctgcggatgctgaaaattggtcataatacatact a" /listShort="ymfF, ymfH, S603, ymfI, ymfJ, ymfK, ymfK, ymfM" /listLong="pgsA, cinA, S604, recA, S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="promotor_-35" promotor_-10 1669274..1669293 /Source="Nicolas_upshift_promotors" /id="U1349" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5994005994006" /psig="0.987012987012987" /xcortree=1918 /SigmaFactorBS="cagcatgcggaggttattGTTTCCTTataaatcctacaGTTG CTATAATTACATGAAAgagtgtttctgcggatgctgaaaattggtcataatacatact a" /listShort="ymfF, ymfH, S603, ymfI, ymfJ, ymfK, ymfK, ymfM" /listLong="pgsA, cinA, S604, recA, S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="promotor_-10" upshifts 1669296 /Source="Nicolas_upshifts" /id="U1349" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5994005994006" /psig="0.987012987012987" /xcortree=1918 /SigmaFactorBS="cagcatgcggaggttattGTTTCCTTataaatcctacaGTTG CTATAATTACATGAAAgagtgtttctgcggatgctgaaaattggtcataatacatact a" /listShort="ymfF, ymfH, S603, ymfI, ymfJ, ymfK, ymfK, ymfM" /listLong="pgsA, cinA, S604, recA, S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="upshifts" promotor_-35 1669308..1669311 /Source="Nicolas_upshift_promotors" /id="U1350" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.430569430569431" /psig="0.430569430569431" /xcortree=811 /SigmaFactorBS="taattacatgaaagagtgtttctgcggATGCtgaaaattggt cataATACATACTAATTaagaaatgaacgaaggaggttccatatgtcatatgttaatg a" /listShort="ymfF, ymfH, S603, ymfI, ymfJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1669327..1669339 /Source="Nicolas_upshift_promotors" /id="U1350" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.430569430569431" /psig="0.430569430569431" /xcortree=811 /SigmaFactorBS="taattacatgaaagagtgtttctgcggATGCtgaaaattggt cataATACATACTAATTaagaaatgaacgaaggaggttccatatgtcatatgttaatg a" /listShort="ymfF, ymfH, S603, ymfI, ymfJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1669341 /Source="Nicolas_upshifts" /id="U1350" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.430569430569431" /psig="0.430569430569431" /xcortree=811 /SigmaFactorBS="taattacatgaaagagtgtttctgcggATGCtgaaaattggt cataATACATACTAATTaagaaatgaacgaaggaggttccatatgtcatatgttaatg a" /listShort="ymfF, ymfH, S603, ymfI, ymfJ" /GFF_Attribute="listLong" /label="upshifts" CDS 1669365..1670645 /gene="ymfF" /locus_tag="BSU_16845" /old_locus_tag="BSU16845" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metalloprotease" /protein_id="NP_389566.2" /db_xref="EnsemblGenomes-Gn:BSU16845" /db_xref="EnsemblGenomes-Tr:CAB13557" /db_xref="GOA:O31764" /db_xref="InterPro:IPR007863" /db_xref="InterPro:IPR011249" /db_xref="SubtiList:BG13426" /db_xref="UniProtKB/Swiss-Prot:O31764" /translation="MSYVNELKSKHGGLTAHIVKTEKFKTVSLIFKMLAPLTKDQVTK RALLPHVLLRGTKSHPKTAGLRSYLDELYGTSVSADLTKKGERHVITFRLEIPNEKYL KDQTPLLEKGLQLLAELVFSPALEGDAFQSQYVAQEKRTLKQRIQAVYDDKMRYSNLR LIQEMCKNDPYALHVNGEIDDVDDITAEQLYETYQSAIQKDQLDLYVVGDVDSNQVQS AIDKYFKTEERTLGMIENNHADEKVQPKEVIDEEDVKQGKLNIGYRTSITYTDQDYPA LQVFNGLFGGFSHSKLFINVREKASLAYYAASRIESFKGLLMVMSGIEVKNFEQAVSI IAEQFQAMKNGDFSEQDIAQTKAVIRNQVLETIDTAYGLSEFLYQQAAAQVEIPIEDF LANIENVTKEDIIKAGEKIQLDTTYFLKGTEGAS*" /label="ymfF CDS" gene 1669365..1670645 /gene="ymfF" /locus_tag="BSU_16845" /old_locus_tag="BSU16845" /label="ymfF gene" CDS 1670642..1671928 /gene="ymfH" /locus_tag="BSU_16860" /old_locus_tag="BSU16860" /EC_number="3.4.24.-" /function="16.6: Maintain" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative processing protease" /protein_id="NP_389568.2" /db_xref="EnsemblGenomes-Gn:BSU16860" /db_xref="EnsemblGenomes-Tr:CAB13559" /db_xref="GOA:O31766" /db_xref="InterPro:IPR007863" /db_xref="InterPro:IPR011249" /db_xref="InterPro:IPR011765" /db_xref="SubtiList:BG13428" /db_xref="UniProtKB/Swiss-Prot:O31766" /translation="MIKPIEYEQLQETLYHEKMSNGLDVYVLPKKGFNKTYAVFTTKY GSIDNRFVPLGKNEMVHVPDGIAHFLEHKLFEKADGDVFQDFSKQGASANAFTSFTRT AYLFSSTSNVERNLETLIDFVQDPYFTEKTVEKEKGIIGQEINMYDDNPDWRLYFGVI ENMYKEHPVRIDIAGTVESISHITKDLLYECYETFYHPSNMLLFIVGPVDPEAIISQV RENQGKKPYTDQPEIKREEVKEQEAVFRKEKEIKMNVQGPKCLVGLKSKNPFKLGKEL LKHELSMNLLLEALFGKSSAQYESLYEKGYIDETFSFDFTAEYGFGFAAIGGDTPEPD QLAEDISSMLLRAGELITAEKIELARKKKIGTFLKALNSPEYIANQFTRYAFLDMSLF DVVTVLEQITLEDVQNVIQEEIAADRLTVCKVVPKS*" /label="ymfH CDS" gene 1670642..1671928 /gene="ymfH" /locus_tag="BSU_16860" /old_locus_tag="BSU16860" /label="ymfH gene" downshifts 1671778 /Source="Nicolas_upshifts" /id="D909" /incds=1 /nref=10 /ntot=159 /MaxReadThrough="5.673" /MaxDrop="3.16735" /score="1.51160893" /energy="-10.4" /TU="U1349,U1350" /idTUdmin="U1350" /TUdmin="-1256" /isTUend="FALSE" /label="downshifts" S_feature 1671929..1671982 /Source="Nicolas_S_feature" /locus_tag="new_1759601_1759654" /HighExp="Etha, dia15, H2O2, G135, G150, G180, Paraq, LBGexp, Oxctl, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.431, 0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S603" CDS 1671983..1672711 /gene="efpI" /locus_tag="BSU_16870" /old_locus_tag="BSU16870" /EC_number="1.1.1.-" /function="16.2: Construct biomass (Anabolism)" /function="16.5: Explore" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15066026, 28787546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15066026, 28787546; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="EF-P-5 aminopentanone reductase (EF-P repair enzyme), NADPH-dependent" /protein_id="NP_389569.2" /db_xref="EnsemblGenomes-Gn:BSU16870" /db_xref="EnsemblGenomes-Tr:CAB13560" /db_xref="GOA:O31767" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13429" /db_xref="UniProtKB/Swiss-Prot:O31767" /translation="MNKTALITGASGGIGKSISETLAARGYNLLLHYNTNQNAAAELA EKLSQMFGVNAEILQADLSAQDGADKLTSSIVQPIDAIVLNSGRSHFGLITDVDNATV QEMVQLHVASPYMLTRNLLPGMIRNKSGAIVAVSSIWGETGASCEVLYSMAKGAQHSF VKGLAKELAPSGIRVNAVAPGAVDTNMMNQFTPAEKEEIADEIPIGRLARPQEIADAT AFLLSEKASYITGQILSVNGGWHC*" /label="efpI CDS" gene 1671983..1672711 /gene="efpI" /locus_tag="BSU_16870" /old_locus_tag="BSU16870" /label="efpI gene" promotor_-35 1672727..1672733 /Source="Nicolas_upshift_promotors" /id="U1351" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=829 /SigmaFactorBS="tcggtgaatggcggctggcactgctgatccgaaaatattcgg TGTATAGtttcttttgcgaaGGACACAATAATcttgtaacttcacatgaaatggagga a" /listShort="ymfJ, ymfK, ymfK, ymfM" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1672745 /Source="Nicolas_upshifts" /id="U1351" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=829 /SigmaFactorBS="tcggtgaatggcggctggcactgctgatccgaaaatattcgg TGTATAGtttcttttgcgaaGGACACAATAATcttgtaacttcacatgaaatggagga a" /listShort="ymfJ, ymfK, ymfK, ymfM" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1672747..1672758 /Source="Nicolas_upshift_promotors" /id="U1351" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=829 /SigmaFactorBS="tcggtgaatggcggctggcactgctgatccgaaaatattcgg TGTATAGtttcttttgcgaaGGACACAATAATcttgtaacttcacatgaaatggagga a" /listShort="ymfJ, ymfK, ymfK, ymfM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1672758) /Source="Nicolas_upshifts" /id="U1352" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.945054945054945" /psig="0.050949050949051" /xcortree=702 /SigmaFactorBS="gctatcccagttttctaatactGACATgcttgtttCCTCCAT TTCATGTGaagttacaagattattgtgtccttcgcaaaagaaactatacaccgaatat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1672769..1672783) /Source="Nicolas_upshift_promotors" /id="U1352" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.945054945054945" /psig="0.050949050949051" /xcortree=702 /SigmaFactorBS="gctatcccagttttctaatactGACATgcttgtttCCTCCAT TTCATGTGaagttacaagattattgtgtccttcgcaaaagaaactatacaccgaatat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1672792..1672796) /Source="Nicolas_upshift_promotors" /id="U1352" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.945054945054945" /psig="0.050949050949051" /xcortree=702 /SigmaFactorBS="gctatcccagttttctaatactGACATgcttgtttCCTCCAT TTCATGTGaagttacaagattattgtgtccttcgcaaaagaaactatacaccgaatat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1672792..1673049 /gene="ymfJ" /locus_tag="BSU_16880" /old_locus_tag="BSU16880" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17322312; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_389570.1" /db_xref="EnsemblGenomes-Gn:BSU16880" /db_xref="EnsemblGenomes-Tr:CAB13561" /db_xref="InterPro:IPR021637" /db_xref="InterPro:IPR024702" /db_xref="SubtiList:BG13430" /db_xref="UniProtKB/Swiss-Prot:O31768" /translation="MSVLENWDSWKNFLGDRLNYAQDKGMSQDTITDLATEIGSYLAN EVESKNEQEKVLADLWSVASKDEQHAIANMMVKLVENNSTH*" /label="ymfJ CDS" gene 1672792..1673049 /gene="ymfJ" /locus_tag="BSU_16880" /old_locus_tag="BSU16880" /label="ymfJ gene" downshifts 1673034 /Source="Nicolas_upshifts" /id="D910" /incds=0 /nref=165 /ntot=250 /MaxReadThrough="4.58488" /MaxDrop="7.23574" /score="21.9507801" /energy="-8.7" /TU="U1349,U1351" /idTUdmin="U1350" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1673066) /Source="Nicolas_upshifts" /id="D911" /incds=0 /nref=2 /ntot=15 /MaxReadThrough="3.44398" /MaxDrop="3.96475" /score="-6.33040789" /energy="-7.2" /TU="NA" /idTUdmin="U1344" /TUdmin="-11987" /isTUend="FALSE" /label="downshifts" promotor_-35 1673107..1673110 /Source="Nicolas_upshift_promotors" /id="U1353" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.883116883116883" /psig="0.998001998001998" /xcortree=2284 /SigmaFactorBS="ttcctctcttttttatgttttcctcatcacagcaacattctt CTTTctaattagagaaaaATGCTTTATGATAAAGGAAGgtaaaattttgccacaatga a" /listShort="ymfK, ymfK, ymfM, pgsA, cinA, S604, recA" /listLong="S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="promotor_-35" promotor_-10 1673125..1673144 /Source="Nicolas_upshift_promotors" /id="U1353" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.883116883116883" /psig="0.998001998001998" /xcortree=2284 /SigmaFactorBS="ttcctctcttttttatgttttcctcatcacagcaacattctt CTTTctaattagagaaaaATGCTTTATGATAAAGGAAGgtaaaattttgccacaatga a" /listShort="ymfK, ymfK, ymfM, pgsA, cinA, S604, recA" /listLong="S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="promotor_-10" upshifts 1673125 /Source="Nicolas_upshifts" /id="U1353" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.883116883116883" /psig="0.998001998001998" /xcortree=2284 /SigmaFactorBS="ttcctctcttttttatgttttcctcatcacagcaacattctt CTTTctaattagagaaaaATGCTTTATGATAAAGGAAGgtaaaattttgccacaatga a" /listShort="ymfK, ymfK, ymfM, pgsA, cinA, S604, recA" /listLong="S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="upshifts" CDS 1673179..1673694 /gene="ymfKn" /locus_tag="BSU_16890" /old_locus_tag="BSU16890" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein with ACT domain; N-terminal part of YmfK" /db_xref="SubtiList:BG13431" /translation="MAKLEWYFEYEIQVNRPGLLGDISSLLGMLSINIVTINGVDLSR RGMLLRCRHIDQIKRLESILKTMETIKVTKLREPRLRDRLAVRHGRYIQRDADDKKTF RFERDELGLLVDFMAELFKKEGHKLIGIRGMPRVGKTESIVASSVCEQKVAVCVINLA EADDKKPADCR*" /label="ymfKn CDS" gene 1673179..1673694 /gene="ymfKn" /locus_tag="BSU_16890" /old_locus_tag="BSU16890" /pseudo /label="ymfKn gene" CDS 1673630..1673968 /gene="ymfKc" /locus_tag="BSU_16900" /old_locus_tag="BSU16900" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein with ACT domain; C-terminal part of YmfK" /db_xref="SubtiList:BG13432" /translation="RWLFVSSTLLKQTIRSQLIADEYSTENVFIVDGIVSTRRGSERH LQLVREIMRLPATKVVEHPDIFVQNTEYTLDDFDYIIELRNDPDEVITYEHAEEPQMF DQSGFSSFDF*" /label="ymfKc CDS" gene 1673630..1673968 /gene="ymfKc" /locus_tag="BSU_16900" /old_locus_tag="BSU16900" /pseudo /label="ymfKc gene" CDS 1674035..1674901 /gene="rodZ" /locus_tag="BSU_16910" /old_locus_tag="BSU16910" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 19164570, 22720735, 23879732, 27415800, 27818647" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 19164570, 22720735, 23879732, 27415800, 27818647; Product type f : factor" /codon_start=1 /transl_table=11 /product="cell shape determination factor" /protein_id="NP_389573.3" /db_xref="EnsemblGenomes-Gn:BSU16910" /db_xref="EnsemblGenomes-Tr:CAB13564" /db_xref="GOA:O31771" /db_xref="InterPro:IPR025194" /db_xref="SubtiList:BG13433" /db_xref="UniProtKB/Swiss-Prot:O31771" /translation="MSLDDLQAATKIQKRYLTALEEGNYDIIPGKFYVRAFIKQYAEA VGLDADQLFEEHKKDIPNTYHDDVSEKISGMNLQKEMPKPASKALELLPTILVILGVI VVIAIVYAIIQFANHKNSDDHNAASEKAITQSESKYEIPKDSTLKENQNNSSEKETDT KKETKENEDKKKENDSEKLEIKAAGTEGSLTTYEVSGADKIELELKASDSSWIRVRDE NSSSLKEGTLKKDETYKKDITDQKQVDIRTGYAPNLKIKINGKVLSYELDPKKVMAQT IKIVNKKEEKSS*" /label="rodZ CDS" gene 1674035..1674901 /gene="rodZ" /locus_tag="BSU_16910" /old_locus_tag="BSU16910" /label="rodZ gene" promotor_no_box 1674098..1674198 /Source="Nicolas_upshift_promotors" /id="U1354" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.52947052947053" /psig="0.015984015984016" /xcortree=1494 /SigmaFactorBS="gaaggaaactatgacattattccggggaagttttatgttcgg gcattcatcaagcaatatgcagaagccgttgggcttgatgcggatcagctgtttgagg a" /listShort="pgsA, cinA, S604" /listLong="recA, S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="promotor_no_box" upshifts 1674158 /Source="Nicolas_upshifts" /id="U1354" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.52947052947053" /psig="0.015984015984016" /xcortree=1494 /SigmaFactorBS="gaaggaaactatgacattattccggggaagttttatgttcgg gcattcatcaagcaatatgcagaagccgttgggcttgatgcggatcagctgtttgagg a" /listShort="pgsA, cinA, S604" /listLong="recA, S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="upshifts" downshifts 1674861 /Source="Nicolas_upshifts" /id="D912" /incds=0 /nref=1 /ntot=107 /MaxReadThrough="5.43253" /MaxDrop="2.8328" /score="21.9507801" /energy="-8.7" /TU="U1353,U1354" /idTUdmin="U1351" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 1674951..1675532 /gene="pgsA" /locus_tag="BSU_16920" /old_locus_tag="BSU16920" /EC_number="2.7.8.5" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 15743965, 15849754, 16514141, 16850406, 27818647" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15743965, 15849754, 16514141, 16850406, 27818647; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase" /protein_id="NP_389574.2" /db_xref="EnsemblGenomes-Gn:BSU16920" /db_xref="EnsemblGenomes-Tr:CAB13565" /db_xref="GOA:P46322" /db_xref="InterPro:IPR000462" /db_xref="InterPro:IPR004570" /db_xref="SubtiList:BG11373" /db_xref="UniProtKB/Swiss-Prot:P46322" /translation="MFNLPNKITLARIALIPIFMIIMLAPFDWGRLEVGDESIPVAHL AGAILFIIASTTDWVDGYYARKLNLVTNFGKFLDPLADKLLVSAALIILVQFDLAPAW MVIVIISREFAVTGLRLVLAGTGEVVAANMLGKIKTWAQIIAVSALLLHNLPFELVSF PFADLALWVAVFFTVVSGWEYFSKNWEALKTSN*" /label="pgsA CDS" gene 1674951..1675532 /gene="pgsA" /locus_tag="BSU_16920" /old_locus_tag="BSU16920" /label="pgsA gene" CDS 1675550..1676800 /gene="cinA" /locus_tag="BSU_16930" /old_locus_tag="BSU16930" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10438773, 11703670, 20480359; Product type r: regulator" /codon_start=1 /transl_table=11 /product="competence-damage inducible regulator" /protein_id="NP_389575.2" /db_xref="EnsemblGenomes-Gn:BSU16930" /db_xref="EnsemblGenomes-Tr:CAB13566" /db_xref="InterPro:IPR001453" /db_xref="InterPro:IPR008135" /db_xref="InterPro:IPR008136" /db_xref="InterPro:IPR036425" /db_xref="InterPro:IPR036653" /db_xref="SubtiList:BG11374" /db_xref="UniProtKB/Swiss-Prot:P46323" /translation="MEFPKKAEIIAVGSELLLGQIANTNAQFISKQLAEIGVNVFYHT AVGDNPERLKQVIRIAEERSDFIIFSGGLGPTKDDLTKETIANTLGRPLVLNDEAFQS IEDYFKRTKRTMSPNNRKQALVIEGSDVLANHFGMAPGMLTEHESRYYMLLPGPPSEL RPMFENEAKPLLLKKMGSNEKIVSTVLRFFGIGESQLEADLEDIIDAQTNPTIAPLAA DGEVTLRLTAKHADEKETERLLKETEAVILERVGEFFYGYDDTSLVKELSIACKEKGI TISAAESFTGGLFSEWLTDHSGASKLFAGGVVCYTNDVKQNVLGVKKETLDRFGAVSK ECASELAKGVQKLTGSDIGISFTGVAGPDAQEGHEPGHVFIGISANGKEEVHEFHFAG SRTGIRKRGAKYGCHLILKLLEQK*" /label="cinA CDS" gene 1675550..1676800 /gene="cinA" /locus_tag="BSU_16930" /old_locus_tag="BSU16930" /label="cinA gene" S_feature 1676801..1676927 /Source="Nicolas_S_feature" /locus_tag="new_1764473_1764599" /HighExp="LBGstat, LBGtran, G135, Lbstat, G150, C30, LBGexp, dia0, S0, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.016, 0.998" /TUlongSig="SigA" /TUlongPSig="0.987" /label="S604" promotor_-35 1676907..1676914 /Source="Nicolas_upshift_promotors" /id="U1355" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.863136863136863" /psig=1 /xcortree=1499 /SigmaFactorBS="tcacgccaagaaaaaatccgaatatgcgttcgctttttTCTT GGCAaatcccttcaaacaGGGTATAGTATATGTAGTGGtaacataaaggaggaaaaaa t" /listShort="recA, S605, pbpX" /listLong="S606, S607, ymdA, ymdB, S608, spoVS" /label="promotor_-35" promotor_-10 1676929..1676948 /Source="Nicolas_upshift_promotors" /id="U1355" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.863136863136863" /psig=1 /xcortree=1499 /SigmaFactorBS="tcacgccaagaaaaaatccgaatatgcgttcgctttttTCTT GGCAaatcccttcaaacaGGGTATAGTATATGTAGTGGtaacataaaggaggaaaaaa t" /listShort="recA, S605, pbpX" /listLong="S606, S607, ymdA, ymdB, S608, spoVS" /label="promotor_-10" upshifts 1676929 /Source="Nicolas_upshifts" /id="U1355" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.863136863136863" /psig=1 /xcortree=1499 /SigmaFactorBS="tcacgccaagaaaaaatccgaatatgcgttcgctttttTCTT GGCAaatcccttcaaacaGGGTATAGTATATGTAGTGGtaacataaaggaggaaaaaa t" /listShort="recA, S605, pbpX" /listLong="S606, S607, ymdA, ymdB, S608, spoVS" /label="upshifts" CDS 1676973..1678019 /gene="recA" /locus_tag="BSU_16940" /old_locus_tag="BSU16940" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11555642, 16024744, 16061691, 16267290, 17229847, 22720735, 25939832, 26001966, 26930481, 28344191" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11555642, 16024744, 16061691, 16267290, 17229847, 22720735, 25939832, 26001966, 26930481, 28344191; Product type f: factor" /codon_start=1 /transl_table=11 /product="multifunctional SOS repair factor" /protein_id="NP_389576.2" /db_xref="EnsemblGenomes-Gn:BSU16940" /db_xref="EnsemblGenomes-Tr:CAB13567" /db_xref="GOA:P16971" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013765" /db_xref="InterPro:IPR020584" /db_xref="InterPro:IPR020587" /db_xref="InterPro:IPR020588" /db_xref="InterPro:IPR023400" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10721" /db_xref="UniProtKB/Swiss-Prot:P16971" /translation="MSDRQAALDMALKQIEKQFGKGSIMKLGEKTDTRISTVPSGSLA LDTALGIGGYPRGRIIEVYGPESSGKTTVALHAIAEVQQQGGQAAFIDAEHALDPVYA QKLGVNIEELLLSQPDTGEQALEIAEALVRSGAVDIVVVDSVAALVPKAEIEGDMGDS HVGLQARLMSQALRKLSGAINKSKTIAIFINQIREKVGVMFGNPETTPGGRALKFYSS VRLEVRRAEQLKQGNDVMGNKTKIKVVKNKVAPPFRTAEVDIMYGEGISKEGEIIDLG TELDIVQKSGSWYSYEEERLGQGRENAKQFLKENKDIMLMIQEQIREHYGLDNNGVVQ QQAEETQEELEFEE*" /label="recA CDS" gene 1676973..1678019 /gene="recA" /locus_tag="BSU_16940" /old_locus_tag="BSU16940" /label="recA gene" downshifts 1678031 /Source="Nicolas_upshifts" /id="D913" /incds=0 /nref=201 /ntot=262 /MaxReadThrough="4.54659" /MaxDrop="9.405" /score="23.91264" /energy="-9.7" /TU="U1355" /idTUdmin="U1353" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" S_feature 1678076..1678141 /Source="Nicolas_S_feature" /locus_tag="new_1765748_1765813" /HighExp="S7, S5, S8, S4, H2O2, C30, T5.0H, S6, ferm, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="Sig-, SigA, SigA" /TUlongPSig="0.016, 0.998, 0.987" /label="S605" promotor_-35 1678113..1678122 /Source="Nicolas_upshift_promotors" /id="U1356" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2507 /SigmaFactorBS="caaaaaaatgataaaaatattgctttttttGACAACTTTTtt agggctttatTCGTCTAACAAAACGTgtgcaaaatggaatttattttgggaggaaaaa a" /listShort="pbpX, S606" /listLong="S607, ymdA, ymdB, S608, spoVS, S609, tdh, kbl, ymcB, ymcA" /label="promotor_-35" promotor_-10 1678135..1678150 /Source="Nicolas_upshift_promotors" /id="U1356" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2507 /SigmaFactorBS="caaaaaaatgataaaaatattgctttttttGACAACTTTTtt agggctttatTCGTCTAACAAAACGTgtgcaaaatggaatttattttgggaggaaaaa a" /listShort="pbpX, S606" /listLong="S607, ymdA, ymdB, S608, spoVS, S609, tdh, kbl, ymcB, ymcA" /label="promotor_-10" upshifts 1678143 /Source="Nicolas_upshifts" /id="U1356" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2507 /SigmaFactorBS="caaaaaaatgataaaaatattgctttttttGACAACTTTTtt agggctttatTCGTCTAACAAAACGTgtgcaaaatggaatttattttgggaggaaaaa a" /listShort="pbpX, S606" /listLong="S607, ymdA, ymdB, S608, spoVS, S609, tdh, kbl, ymcB, ymcA" /label="upshifts" CDS 1678187..1679362 /gene="pbpX" /locus_tag="BSU_16950" /old_locus_tag="BSU16950" /function="16.13: Shape" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14762009, 15758244, 21856855" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14762009, 15758244, 21856855; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="penicillin-binding endopeptidase X (lysozyme resistance)" /protein_id="NP_389577.1" /db_xref="EnsemblGenomes-Gn:BSU16950" /db_xref="EnsemblGenomes-Tr:CAB13568" /db_xref="GOA:O31773" /db_xref="InterPro:IPR001466" /db_xref="InterPro:IPR012338" /db_xref="SubtiList:BG12642" /db_xref="UniProtKB/Swiss-Prot:O31773" /translation="MTSPTRRRTAKRRRRKLNKRGKLLFGLLAVMVCITIWNALHRNS EENEPSQETAAVSNTDQKKEVKKKTAKKSEEQIKTVDRNQKISNYLKEIGFSGTAMIV RNGEIVTNKGFGYADRKHYIQNNPLTSFYVGSSQKALIATAILQLEEKGKLQTSDPVS TYLPHFPNGQTITLKNLLTHTSGINGHIEGNGAITPDDLIKDIELQGIKRQPGVWDYK DSNYSVLAYIIAEVSGEPYEQYIKNHIFKPAGMTHAGFYKTYEKEPYPAVGYKMEGSK TVTPYIPDLSQLYGAGDIYMSAIDMYKFDQALIDGKLYSQKSYEKMFTPGSSSTYGMG FYVAPGSYSNHGVMPGFNILNSFSKSGQTIVILFSNIQNNAKLGQVNNKIYQLLNQE* " /label="pbpX CDS" gene 1678187..1679362 /gene="pbpX" /locus_tag="BSU_16950" /old_locus_tag="BSU16950" /label="pbpX gene" S_feature 1679363..1679462 /Source="Nicolas_S_feature" /locus_tag="new_1767035_1767134" /HighExp="dia0, LBGexp, Lbexp, Oxctl, Paraq, H2O2, C30, G150, Mt0, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.54369999999999996" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="SigA, Sig-, SigA, SigA" /TUlongPSig="1, 0.016, 0.998, 0.987" /label="S606" promotor_-35 1679436..1679443 /Source="Nicolas_upshift_promotors" /id="U1357" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.791208791208791" /psig=1 /xcortree=1906 /SigmaFactorBS="aagaagactggcctgcaaacgttaagatggcaAGCTTGACaa gtatttccgacACATTTACAATGAAGTTGTAacatttgtttttttaacatgattgtta a" /listShort="S607, ymdA, ymdB, S608, spoVS" /listLong="S609, tdh, kbl, ymcB, ymcA" /label="promotor_-35" promotor_-10 1679457..1679476 /Source="Nicolas_upshift_promotors" /id="U1357" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.791208791208791" /psig=1 /xcortree=1906 /SigmaFactorBS="aagaagactggcctgcaaacgttaagatggcaAGCTTGACaa gtatttccgacACATTTACAATGAAGTTGTAacatttgtttttttaacatgattgtta a" /listShort="S607, ymdA, ymdB, S608, spoVS" /listLong="S609, tdh, kbl, ymcB, ymcA" /label="promotor_-10" S_feature 1679464..1679637 /Source="Nicolas_S_feature" /locus_tag="new_1767136_1767309" /HighExp="M9-stat, T3.30H, BC, T2.0H, T3.0H, T-1.40H, T1.30H, T2.30H, T4.0H, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigWXY, SigA, Sig-, SigA, SigA" /TUlongPSig="1, 1, 0.016, 0.998, 0.987" /label="S607" upshifts 1679464 /Source="Nicolas_upshifts" /id="U1357" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.791208791208791" /psig=1 /xcortree=1906 /SigmaFactorBS="aagaagactggcctgcaaacgttaagatggcaAGCTTGACaa gtatttccgacACATTTACAATGAAGTTGTAacatttgtttttttaacatgattgtta a" /listShort="S607, ymdA, ymdB, S608, spoVS" /listLong="S609, tdh, kbl, ymcB, ymcA" /label="upshifts" CDS 1679638..1681200 /gene="rny" /locus_tag="BSU_16960" /old_locus_tag="BSU16960" /EC_number="3.1.26.-" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 17005971, 19779461, 21803996, 21815947, 21862575, 22720735, 25402410, 26797123" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17005971, 19779461, 21803996, 21815947, 21862575, 22720735, 25402410, 26797123; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endoribonuclease Y" /protein_id="NP_389578.1" /db_xref="EnsemblGenomes-Gn:BSU16960" /db_xref="EnsemblGenomes-Tr:CAB13569" /db_xref="GOA:O31774" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR004087" /db_xref="InterPro:IPR004088" /db_xref="InterPro:IPR006674" /db_xref="InterPro:IPR006675" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR017705" /db_xref="InterPro:IPR022711" /db_xref="InterPro:IPR036612" /db_xref="SubtiList:BG13420" /db_xref="UniProtKB/Swiss-Prot:O31774" /translation="MTPIMMVLISILLILLGLVVGYFVRKTIAEAKIAGARGAAEQIL EDAKRDAEALKKEALLEAKDEIHKLRIDAEQEVRERRNELQKQENRLLQKEENLDRKH EGIDKREAMLEKKDHSLNERQQHIEEMESKVDEMIRMQQSELERISSLTRDEAKQIIL ERVENELSHDIAIMTKETENRAKEEADKKAKNILSLALQRCAADHVAETTVSVVNLPN DEMKGRIIGREGRNIRTLETLTGIDLIIDDTPEAVILSGFDPIRRETARIALDKLVQD GRIHPARIEEMVEKSRREVDDYIREMGEQTTFEVGVHGLHPDLIKILGRLKFRTSYGQ NVLKHSMEVAFLAGLMASELGEDAKLAKRAGLLHDIGKAIDHEVEGSHVEIGVELATK YKEHPVVINSIASHHGDEEPTSIIAVLVAAADALSAARPGARSETLENYIRRLEKLEE ISESYEGVEKSFAIQAGREVRIMVKPDSINDLEAHRLARDIRKRIEDELDYPGHIKVT VIRETRAVEYAK*" /label="rny CDS" gene 1679638..1681200 /gene="rny" /locus_tag="BSU_16960" /old_locus_tag="BSU16960" /label="rny gene" downshifts 1681177 /Source="Nicolas_upshifts" /id="D914" /incds=0 /nref=243 /ntot=268 /MaxReadThrough="5.32126" /MaxDrop="5.3789" /score="10.4712371" /energy="-9" /TU="U1357" /idTUdmin="U1357" /TUdmin="-1342" /isTUend="FALSE" /label="downshifts" CDS 1681269..1682063 /gene="pdeB" /locus_tag="BSU_16970" /old_locus_tag="BSU16970" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:19376879, 21856853, 24163345, 26904951, 26906740" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19376879, 21856853, 24163345, 26904951, 26906740; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2'3' and 3'5' cyclic nucleotide monophosphates phosphodiesterase involved in biofilm formation" /protein_id="NP_389579.2" /db_xref="EnsemblGenomes-Gn:BSU16970" /db_xref="EnsemblGenomes-Tr:CAB13570" /db_xref="GOA:O31775" /db_xref="InterPro:IPR005235" /db_xref="InterPro:IPR029052" /db_xref="PDB:4B2O" /db_xref="SubtiList:BG13421" /db_xref="UniProtKB/Swiss-Prot:O31775" /translation="MRILFIGDVVGSPGRDMVKEYVPKLKTKYKPHFTIINGENAAHG KGLTEKIYHSLIQSGADAITMGNHTWDKKEIFDFIDDVPNLVRPANFPEGTPGKGITY VKANGKELAVINLQGRTFLPPLDDPFLKADELIAEAAKRTPYIFIDFHAEATSEKLAL GWYTDGRASAVVGTHTHVQTADNRILPKGTAYITDVGMTGPYDGILGMDRETIIKRFK TNLPVRFTVAEGKTTLSGVVIDIDDQTKKAVKIERILINDDHMFFE*" /label="pdeB CDS" gene 1681269..1682063 /gene="pdeB" /locus_tag="BSU_16970" /old_locus_tag="BSU16970" /label="pdeB gene" promotor_-35 1681818..1681823 /Source="Nicolas_upshift_promotors" /id="U1358" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.91008991008991" /psig="0.91008991008991" /xcortree=1456 /SigmaFactorBS="cgtgcaaacagcggataacCGCATTttgccgaagggaacgGC ATATATTACTGATGTGGgaatgactggcccgtatgacggtatactggggatggacaga g" /listShort="S608, spoVS, S609" /listLong="tdh, kbl, ymcB, ymcA" /label="promotor_-35" promotor_-10 1681839..1681857 /Source="Nicolas_upshift_promotors" /id="U1358" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.91008991008991" /psig="0.91008991008991" /xcortree=1456 /SigmaFactorBS="cgtgcaaacagcggataacCGCATTttgccgaagggaacgGC ATATATTACTGATGTGGgaatgactggcccgtatgacggtatactggggatggacaga g" /listShort="S608, spoVS, S609" /listLong="tdh, kbl, ymcB, ymcA" /label="promotor_-10" upshifts 1681859 /Source="Nicolas_upshifts" /id="U1358" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.91008991008991" /psig="0.91008991008991" /xcortree=1456 /SigmaFactorBS="cgtgcaaacagcggataacCGCATTttgccgaagggaacgGC ATATATTACTGATGTGGgaatgactggcccgtatgacggtatactggggatggacaga g" /listShort="S608, spoVS, S609" /listLong="tdh, kbl, ymcB, ymcA" /label="upshifts" promotor_-35 1682107..1682112 /Source="Nicolas_upshift_promotors" /id="U1359" /multdbtbs="SigH" /comp="M3" /sig="SigEF" /pcomp="0.916083916083916" /psig="0.916083916083916" /xcortree=759 /SigmaFactorBS="gttgaacatatggttattttataaaaatattaaaaagaaaag caGGAATAtagcaactccttagtGAATATAGTAAAAATGGAAggtagcccgctatttt t" /listShort="S608, spoVS, S609, tdh" /listLong="kbl, ymcB, ymcA" /label="promotor_-35" S_feature 1682123..1682262 /Source="Nicolas_S_feature" /locus_tag="new_1769795_1769934" /HighExp="T5.0H, LoTm, BT, B60, S8, M9-stat, S6, BC, B36, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigEF, SigA" /TUshortPSig="0.916, 0.91, 1" /TUlongSig="SigWXY, SigA, Sig-, SigA, SigA" /TUlongPSig="1, 1, 0.016, 0.998, 0.987" /label="S608" upshifts 1682123 /Source="Nicolas_upshifts" /id="U1359" /multdbtbs="SigH" /comp="M3" /sig="SigEF" /pcomp="0.916083916083916" /psig="0.916083916083916" /xcortree=759 /SigmaFactorBS="gttgaacatatggttattttataaaaatattaaaaagaaaag caGGAATAtagcaactccttagtGAATATAGTAAAAATGGAAggtagcccgctatttt t" /listShort="S608, spoVS, S609, tdh" /listLong="kbl, ymcB, ymcA" /label="upshifts" promotor_-10 1682128..1682146 /Source="Nicolas_upshift_promotors" /id="U1359" /multdbtbs="SigH" /comp="M3" /sig="SigEF" /pcomp="0.916083916083916" /psig="0.916083916083916" /xcortree=759 /SigmaFactorBS="gttgaacatatggttattttataaaaatattaaaaagaaaag caGGAATAtagcaactccttagtGAATATAGTAAAAATGGAAggtagcccgctatttt t" /listShort="S608, spoVS, S609, tdh" /listLong="kbl, ymcB, ymcA" /label="promotor_-10" upshifts complement(1682155) /Source="Nicolas_upshifts" /id="U1360" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.763236763236763" /psig="0.0679320679320679" /xcortree=695 /SigmaFactorBS="acaatcattattagatgttgctaTCCAAaaagccatCCCCAC AATGCTTTtcaaaaatagcgggctaccttccatttttactatattcactaaggagttg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1682166..1682179) /Source="Nicolas_upshift_promotors" /id="U1360" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.763236763236763" /psig="0.0679320679320679" /xcortree=695 /SigmaFactorBS="acaatcattattagatgttgctaTCCAAaaagccatCCCCAC AATGCTTTtcaaaaatagcgggctaccttccatttttactatattcactaaggagttg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1682188..1682192) /Source="Nicolas_upshift_promotors" /id="U1360" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.763236763236763" /psig="0.0679320679320679" /xcortree=695 /SigmaFactorBS="acaatcattattagatgttgctaTCCAAaaagccatCCCCAC AATGCTTTtcaaaaatagcgggctaccttccatttttactatattcactaaggagttg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1682199) /Source="Nicolas_upshifts" /id="D915" /incds=0 /nref=5 /ntot=35 /MaxReadThrough="1.51152" /MaxDrop="3.63977" /score="3.80280375" /energy="-6.7" /TU="NA" /idTUdmin="U1366" /TUdmin=10274 /isTUend="FALSE" /label="downshifts" CDS 1682263..1682523 /gene="spoVS" /locus_tag="BSU_16980" /old_locus_tag="BSU16980" /function="16.3: Control" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:7559352, 16428420, 18562273" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7559352, 16428420, 18562273; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator required for dehydratation of the spore core and assembly of the coat (stage V sporulation)" /protein_id="NP_389580.1" /db_xref="EnsemblGenomes-Gn:BSU16980" /db_xref="EnsemblGenomes-Tr:CAB13571" /db_xref="GOA:P45693" /db_xref="InterPro:IPR007347" /db_xref="SubtiList:BG11245" /db_xref="UniProtKB/Swiss-Prot:P45693" /translation="MEILKVSAKSSPNSVAGALAGVLRERGAAEIQAIGAGALNQAVK AVAIARGFVAPSGVDLICIPAFTDIQIDGEERTAIKLIVEPR*" /label="spoVS CDS" gene 1682263..1682523 /gene="spoVS" /locus_tag="BSU_16980" /old_locus_tag="BSU16980" /label="spoVS gene" downshifts 1682475 /Source="Nicolas_upshifts" /id="D916" /incds=0 /nref=1 /ntot=27 /MaxReadThrough="8.31914" /MaxDrop="4.27515" /score="5.18548432" /energy="-12.5" /TU="U1357,U1358,U1359" /idTUdmin="U1357" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" downshifts complement(1682507) /Source="Nicolas_upshifts" /id="D917" /incds=0 /nref=3 /ntot=15 /MaxReadThrough="1.16149" /MaxDrop="3.88837" /score="3.80280375" /energy="-6.7" /TU="NA" /idTUdmin="U1366" /TUdmin=9966 /isTUend="FALSE" /label="downshifts" downshifts 1682519 /Source="Nicolas_upshifts" /id="D918" /incds=0 /nref=171 /ntot=265 /MaxReadThrough="4.08266" /MaxDrop="5.124" /score="5.18548432" /energy="-12.5" /TU="U1358,U1359" /idTUdmin="U1357" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1682564..1682738 /Source="Nicolas_S_feature" /locus_tag="new_1770236_1770410" /HighExp="S6, S8, S7, M9-stat, Lbstat, BT, S5, T1.30H, T2.0H, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigEF" /TUshortPSig="0.916, 0.91" /TUlongSig="SigA, SigWXY" /TUlongPSig="1, 1" /label="S609" promotor_-35 1682722..1682729 /Source="Nicolas_upshift_promotors" /id="U1361" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.825174825174825" /psig="0.999000999001" /xcortree=322 /SigmaFactorBS="ttttcaagacagatacttttgtccttctggaaaagacagttc TGTTTACGcttattccatatcaTGGTACAATCCGAATATAACaagaatttttcaagga g" /listShort="tdh, kbl, ymcB, ymcA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1682740 /Source="Nicolas_upshifts" /id="U1361" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.825174825174825" /psig="0.999000999001" /xcortree=322 /SigmaFactorBS="ttttcaagacagatacttttgtccttctggaaaagacagttc TGTTTACGcttattccatatcaTGGTACAATCCGAATATAACaagaatttttcaagga g" /listShort="tdh, kbl, ymcB, ymcA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1682744..1682763 /Source="Nicolas_upshift_promotors" /id="U1361" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.825174825174825" /psig="0.999000999001" /xcortree=322 /SigmaFactorBS="ttttcaagacagatacttttgtccttctggaaaagacagttc TGTTTACGcttattccatatcaTGGTACAATCCGAATATAACaagaatttttcaagga g" /listShort="tdh, kbl, ymcB, ymcA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1682789..1683832 /gene="tdh" /locus_tag="BSU_16990" /old_locus_tag="BSU16990" /EC_number="1.1.1.103" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8519804, 16817900, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="threonine 3-dehydrogenase" /protein_id="NP_389581.1" /db_xref="EnsemblGenomes-Gn:BSU16990" /db_xref="EnsemblGenomes-Tr:CAB13572" /db_xref="GOA:O31776" /db_xref="InterPro:IPR002328" /db_xref="InterPro:IPR004627" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12685" /db_xref="UniProtKB/Swiss-Prot:O31776" /translation="MQSGKMKALMKKDGAFGAVLTEVPIPEIDKHEVLIKVKAASICG TDVHIYNWDQWARQRIKTPYVFGHEFSGIVEGVGENVSSVKVGEYVSAETHIVCGECV PCLTGKSHVCTNTAIIGVDTAGCFAEYVKVPADNIWRNPADMDPSIASIQEPLGNAVH TVLESQPAGGTTAVIGCGPIGLMAVAVAKAAGASQVIAIDKNEYRLRLAKQMGATCTV SIEKEDPLKIVSALTSGEGADLVCEMSGHPSAIAQGLAMAANGGRFHILSLPEHPVTI DLTNKVVFKGLTIQGITGRKMFSTWRQVSQLISSNMIDLAPVITHQFPLEEFEKGFEL MRSGQCGKVILIP*" /label="tdh CDS" gene 1682789..1683832 /gene="tdh" /locus_tag="BSU_16990" /old_locus_tag="BSU16990" /label="tdh gene" CDS 1683845..1685023 /gene="kbl" /locus_tag="BSU_17000" /old_locus_tag="BSU17000" /EC_number="2.3.1.29" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17146529, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-amino-3-ketobutyrate CoA ligase (glycine acetyl transferase)" /protein_id="NP_389582.1" /db_xref="EnsemblGenomes-Gn:BSU17000" /db_xref="EnsemblGenomes-Tr:CAB13573" /db_xref="GOA:O31777" /db_xref="InterPro:IPR001917" /db_xref="InterPro:IPR004723" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR010962" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG12610" /db_xref="UniProtKB/Swiss-Prot:O31777" /translation="MTKEFEFLKAELNSMKENHTWQDIKQLESMQGPSVTVNHQKVIQ LSSNNYLGFTSHPRLINAAQEAVQQYGAGTGSVRTIAGTFTMHQELEKKLAAFKKTEA ALVFQSGFTTNQGVLSSILSKEDIVISDELNHASIIDGIRLTKADKKVYQHVNMSDLE RVLRKSMNYRMRLIVTDGVFSMDGNIAPLPDIVELAEKYDAFVMVDDAHASGVLGENG RGTVNHFGLDGRVHIQVGTLSKAIGVLGGYAAGSKVLIDYLRHKGRPFLFSTSHPPAV TAACMEAIDVLLEEPEHMERLWENTAYFKAMLVKMGLTLTKSETPILPILIGDEGVAK QFSDQLLSRGVFAQSIVFPTVAKGKARIRTIITAEHTKDELDQALDVIEKTAKELQLL *" /label="kbl CDS" gene 1683845..1685023 /gene="kbl" /locus_tag="BSU_17000" /old_locus_tag="BSU17000" /label="kbl gene" downshifts 1685005 /Source="Nicolas_upshifts" /id="D919" /incds=0 /nref=3 /ntot=25 /MaxReadThrough="5.75732" /MaxDrop="3.4918" /score="4.73069387" /energy="-12.5" /TU="U1361" /idTUdmin="U1359" /TUdmin=1936 /isTUend="FALSE" /label="downshifts" promotor_-35 1685103..1685106 /Source="Nicolas_upshift_promotors" /id="U1362" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.681318681318681" /psig=1 /xcortree=2732 /SigmaFactorBS="ttccttattgattattattctcaatgagtgtacaatgatagg ttgccaGTTGtgcagagcttcaatAACCTTTATACTGAAGGGTGgaagtttggtttga a" /listShort="ymcB, ymcA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1685115 /Source="Nicolas_upshifts" /id="U1362" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.681318681318681" /psig=1 /xcortree=2732 /SigmaFactorBS="ttccttattgattattattctcaatgagtgtacaatgatagg ttgccaGTTGtgcagagcttcaatAACCTTTATACTGAAGGGTGgaagtttggtttga a" /listShort="ymcB, ymcA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1685121..1685140 /Source="Nicolas_upshift_promotors" /id="U1362" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.681318681318681" /psig=1 /xcortree=2732 /SigmaFactorBS="ttccttattgattattattctcaatgagtgtacaatgatagg ttgccaGTTGtgcagagcttcaatAACCTTTATACTGAAGGGTGgaagtttggtttga a" /listShort="ymcB, ymcA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1685171..1686700 /gene="miaB" /locus_tag="BSU_17010" /old_locus_tag="BSU17010" /EC_number="2.8.4.3" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15175311, 18307109, 20472640, 20584901, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15175311, 18307109, 20472640, 20584901, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enzyme for ms(2)i(6)A formation for tRNA modification" /protein_id="NP_389583.1" /db_xref="EnsemblGenomes-Gn:BSU17010" /db_xref="EnsemblGenomes-Tr:CAB13574" /db_xref="GOA:O31778" /db_xref="InterPro:IPR002792" /db_xref="InterPro:IPR005839" /db_xref="InterPro:IPR006463" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013848" /db_xref="InterPro:IPR020612" /db_xref="InterPro:IPR023404" /db_xref="SubtiList:BG13418" /db_xref="UniProtKB/Swiss-Prot:O31778" /translation="MNEKQKLESGQVHPSDKKSEKDYSKYFEAVYIPPSLKDAKKRGK EAVTYHNDFKISEQFKGLGDGRKFYIRTYGCQMNEHDTEVMAGIFMALGYEATNSVDD ANVILLNTCAIRENAENKVFGELGHLKALKKNNPDLILGVCGCMSQEESVVNRILKKH PFVDMIFGTHNIHRLPELLSEAYLSKEMVVEVWSKEGDVIENLPKVRNGKIKGWVNIM YGCDKFCTYCIVPYTRGKERSRRPEDIIQEVRRLASEGYKEITLLGQNVNAYGKDFED MTYGLGDLMDELRKIDIPRIRFTTSHPRDFDDRLIEVLAKGGNLLDHIHLPVQSGSSE VLKLMARKYDRERYMELVRKIKEAMPNASLTTDIIVGFPNETDEQFEETLSLYREVEF DSAYTFIYSPREGTPAAKMKDNVPMRVKKERLQRLNALVNEISAKKMKEYEGKVVEVL VEGESKNNPDILAGYTEKSKLVNFKGPKEAIGKIVRVKIQQAKTWSLDGEMVGEAIEV K*" /label="miaB CDS" gene 1685171..1686700 /gene="miaB" /locus_tag="BSU_17010" /old_locus_tag="BSU17010" /label="miaB gene" CDS 1686702..1687133 /gene="ricA" /locus_tag="BSU_17020" /old_locus_tag="BSU17020" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10712692, 15175311, 15661000, 22720735, 23490197, 26434553, 27501195, 28295778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10712692, 15175311, 15661000, 22720735, 23490197, 26434553, 27501195, 28295778; Product type r: regulator" /codon_start=1 /transl_table=11 /product="master regulator for biofilm formation via regulation of RNase Y (RicAFT complex / FAD / two [4Fe-4S]2+)" /protein_id="NP_389584.1" /db_xref="EnsemblGenomes-Gn:BSU17020" /db_xref="EnsemblGenomes-Tr:CAB13575" /db_xref="InterPro:IPR010368" /db_xref="InterPro:IPR016783" /db_xref="InterPro:IPR023378" /db_xref="PDB:2PIH" /db_xref="SubtiList:BG13417" /db_xref="UniProtKB/Swiss-Prot:O31779" /translation="MTLYSKKDIVQQARNLAKMISETEEVDFFKRAEAQINENDKVST IVNQIKALQKQAVNLKHYEKHEALKQVEAKIDALQEELEEIPVIQEFRDSQMEVNDLL QLVAHTISNQVTNEIITSTGGDLLKGETGSKVKHSNNSCSL*" /label="ricA CDS" gene 1686702..1687133 /gene="ricA" /locus_tag="BSU_17020" /old_locus_tag="BSU17020" /label="ricA gene" downshifts 1687116 /Source="Nicolas_upshifts" /id="D920" /incds=0 /nref=255 /ntot=267 /MaxReadThrough="0.9572" /MaxDrop="7.73043" /score="21.1260722" /energy="-10.3" /TU="NA" /idTUdmin="U1361" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 1687264..1687269 /Source="Nicolas_upshift_promotors" /id="U1363" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1090 /SigmaFactorBS="cagccgcgtataaactttatcgcacttataaGTAAAGtttct aggcacccctGCATACAATGGAACAGAAActttgtatttttatattttatttataaaa a" /listShort="S610, cotE, mutS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1687285..1687303 /Source="Nicolas_upshift_promotors" /id="U1363" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1090 /SigmaFactorBS="cagccgcgtataaactttatcgcacttataaGTAAAGtttct aggcacccctGCATACAATGGAACAGAAActttgtatttttatattttatttataaaa a" /listShort="S610, cotE, mutS" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1687293..1687394 /Source="Nicolas_S_feature" /locus_tag="new_1774965_1775066" /HighExp="S3, S5, S8, S4, S6, S7, B36, BT, Pyr, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S610" upshifts 1687293 /Source="Nicolas_upshifts" /id="U1363" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1090 /SigmaFactorBS="cagccgcgtataaactttatcgcacttataaGTAAAGtttct aggcacccctGCATACAATGGAACAGAAActttgtatttttatattttatttataaaa a" /listShort="S610, cotE, mutS" /GFF_Attribute="listLong" /label="upshifts" CDS 1687395..1687940 /gene="cotE" /locus_tag="BSU_17030" /old_locus_tag="BSU17030" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11737650, 14563859, 14973022, 17172339, 20023017, 22773792, 25259857, 26821119, 27320701" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11737650, 14563859, 14973022, 17172339, 20023017, 22773792, 25259857, 26821119, 27320701; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="morphogenic spore protein" /protein_id="NP_389585.1" /db_xref="EnsemblGenomes-Gn:BSU17030" /db_xref="EnsemblGenomes-Tr:CAB13576" /db_xref="GOA:P14016" /db_xref="InterPro:IPR018901" /db_xref="SubtiList:BG10494" /db_xref="UniProtKB/Swiss-Prot:P14016" /translation="MSEYREIITKAVVAKGRKFTQCTNTISPEKKPSSILGGWIINHK YDAEKIGKTVEIEGYYDINVWYSYADNTKTEVVTERVKYVDVIKLRYRDNNYLDDEHE VIAKVLQQPNCLEVTISPNGNKIVVQAEREFLAEVVGETKVVVEVNPDWEEDDEEDWE DELDEELEDINPEFLVGDPEE*" /label="cotE CDS" gene 1687395..1687940 /gene="cotE" /locus_tag="BSU_17030" /old_locus_tag="BSU17030" /label="cotE gene" downshifts 1687934 /Source="Nicolas_upshifts" /id="D921" /incds=0 /nref=64 /ntot=97 /MaxReadThrough="4.37388" /MaxDrop="8.23792" /score="10.7927556" /energy="-12.6" /TU="U1363" /idTUdmin="U1363" /TUdmin="-745" /isTUend="FALSE" /label="downshifts" downshifts complement(1687941) /Source="Nicolas_upshifts" /id="D922" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="4.21458" /MaxDrop="3.44208" /score="12.3953461" /energy="-11.4" /TU="NA" /idTUdmin="U1366" /TUdmin=4532 /isTUend="FALSE" /label="downshifts" promotor_-35 1687998..1688001 /Source="Nicolas_upshift_promotors" /id="U1364" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2577 /SigmaFactorBS="agtacccccaagtctcttttttatattgatatatcattCTTT tatcactttttgttTATGTTATAATGAAGGTTGGaaaatagaaacgttgatacatagt g" /listShort="mutS, mutL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1688016..1688035 /Source="Nicolas_upshift_promotors" /id="U1364" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2577 /SigmaFactorBS="agtacccccaagtctcttttttatattgatatatcattCTTT tatcactttttgttTATGTTATAATGAAGGTTGGaaaatagaaacgttgatacatagt g" /listShort="mutS, mutL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1688020 /Source="Nicolas_upshifts" /id="U1364" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2577 /SigmaFactorBS="agtacccccaagtctcttttttatattgatatatcattCTTT tatcactttttgttTATGTTATAATGAAGGTTGGaaaatagaaacgttgatacatagt g" /listShort="mutS, mutL" /GFF_Attribute="listLong" /label="upshifts" CDS 1688073..1690649 /gene="mutS" /locus_tag="BSU_17040" /old_locus_tag="BSU17040" /function="16.5: Explore" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15375129, 16269814, 23998896, 26343983" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15375129, 16269814, 23998896, 26343983; Product type f: factor" /codon_start=1 /transl_table=11 /product="DNA mismatch repair recognition factor" /protein_id="NP_389586.2" /db_xref="EnsemblGenomes-Gn:BSU17040" /db_xref="EnsemblGenomes-Tr:CAB13577" /db_xref="GOA:P49849" /db_xref="InterPro:IPR000432" /db_xref="InterPro:IPR005748" /db_xref="InterPro:IPR007695" /db_xref="InterPro:IPR007696" /db_xref="InterPro:IPR007860" /db_xref="InterPro:IPR007861" /db_xref="InterPro:IPR016151" /db_xref="InterPro:IPR017261" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036187" /db_xref="InterPro:IPR036678" /db_xref="SubtiList:BG11403" /db_xref="UniProtKB/Swiss-Prot:P49849" /translation="MAGYTPMIQQYLKIKAEHQDAFLFFRLGDFYEMFFEDAKKASQE LEITLTSRDGGAAEKIPMCGVPYHSASAYIEQLIKKGYKVAICEQTEDPKAAKGVVKR EVVQLITPGTVMDGKGIHESENNFIASVSACSNGYGLALSDLTTGENLAVLIERLEDV ISEIYSVGAREIVVSGSLDADTVAQLRERCGATISIEDGETDEHVTIIEHLNNEDITK TFLRLYTYLKRTQKRSLDHLQPVQVYELEEAMKIDLYSKRNLELTETIRSKNKKGSLL WLLDETKTAMGGRLLKQWIDRPLIRVNQIEERQEMVETLMSHFFEREDLRERLKEVYD LERLAGRVAFGNVNARDLIQLKESLKQVPGIKQLVASLAHDKAKERAKRIDPCGDVLE LLEEALYENPPLSVKEGNLIKDGYNQKLDEYRDASRNGKDWIARLEQQEREYTGIRSL KVGFNKVFGYYIEVTKANLHLLEEGRYERKQTLTNAERYITPELKEKEALILEAENNI CELEYELFTELREKVKQYIPRLQQLAKQMSELDALQCFATISENRHYTKPEFSKDEVE VIEGRHPVVEKVMDSQEYVPNNCMMGDNRQMLLITGPNMSGKSTYMRQIALISIMAQI GCFVPAKKAVLPIFDQIFTRIGAADDLISGQSTFMVEMLEAKNAIVNATKNSLILFDE IGRGTSTYDGMALAQAIIEYVHDHIGAKTLFSTHYHELTVLEDKLPQLKNVHVRAEEY NGTVVFLHQIKEGAADKSYGIHVAQLAELPGDLIARAQDILKELEHSGNKPEVPVQKP QVKEEPAQLSFFDEAEKPAETPKLSKKEKQVIDAFKSLNILDMTPLEAMNEMYKLQKK LH*" /label="mutS CDS" gene 1688073..1690649 /gene="mutS" /locus_tag="BSU_17040" /old_locus_tag="BSU17040" /label="mutS gene" CDS 1690665..1692548 /gene="mutL" /locus_tag="BSU_17050" /old_locus_tag="BSU17050" /function="16.8: Protect" /function="16.5: Explore" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15375129, 22843852, 26343983, 26384423, 27369079" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15375129, 22843852, 26343983, 26384423, 27369079; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA mismatch repair endonuclease" /protein_id="NP_389587.1" /db_xref="EnsemblGenomes-Gn:BSU17050" /db_xref="EnsemblGenomes-Tr:CAB13578" /db_xref="GOA:P49850" /db_xref="InterPro:IPR002099" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR013507" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR014762" /db_xref="InterPro:IPR014790" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR020667" /db_xref="InterPro:IPR036890" /db_xref="InterPro:IPR037198" /db_xref="PDB:3GAB" /db_xref="PDB:3KDG" /db_xref="PDB:3KDK" /db_xref="SubtiList:BG11402" /db_xref="UniProtKB/Swiss-Prot:P49850" /translation="MAKVIQLSDELSNKIAAGEVVERPASVVKELVENAIDADSTVIE IDIEEAGLASIRVLDNGEGMENEDCKRAFRRHATSKIKDENDLFRVRTLGFRGEALPS IASVSHLEITTSTGEGAGTKLVLQGGNIISESRSSSRKGTEIVVSNLFFNTPARLKYM KTVHTELGNITDVVNRIALAHPEVSIRLRHHGKNLLQTNGNGDVRHVLAAIYGTAVAK KMLPLHVSSLDFEVKGYIALPEITRASRNYMSSVVNGRYIKNFPLVKAVHEGYHTLLP IGRHPITFIEITMDPILVDVNVHPSKLEVRLSKETELHDLIRDGIKDVFKQQQLIPSA QVPKKSAPAIKNEQQFITFDEKPPEKKVPEKSTAPSYSPMKLSSVVKEPVDAEEKLPP LQFDAPPIVDQEQTLEVSDVSAEQPETFEQECHEEQPQPASDRVPIMYPIGQMHGTYI LAQNENGLYIIDQHAAQERIKYEYFREKVGEVEPEVQEMIVPLTFHYSTNEALIIEQH KQELESVGVFLESFGSNSYIVRCHPAWFPKGEEAELIEEIIQQVLDSKNIDIKKLREE AAIMMSCKGSIKANRHLRNDEIKALLDDLRSTSDPFTCPHGRPIIIHHSTYEMEKMFK RVM*" /label="mutL CDS" gene 1690665..1692548 /gene="mutL" /locus_tag="BSU_17050" /old_locus_tag="BSU17050" /label="mutL gene" S_feature complement(1692451..1692945) /Source="Nicolas_S_feature" /locus_tag="new_1780123_1780617_c" /HighExp="M9-stat, LBGstat, LPhT, T2.0H, Lbstat, C30, T2.30H, M0t90, T1.30H, HiOs" /AntisenseName="mutL" /AntisenseCor="0.27126904061692803" /AntisenseRegPval="-5.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S611" downshifts 1692463 /Source="Nicolas_upshifts" /id="D923" /incds=1 /nref=216 /ntot=257 /MaxReadThrough="2.0064" /MaxDrop="5.37369" /score="33.4967163" /energy="-18.6" /TU="NA" /idTUdmin="U1364" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1692473) /Source="Nicolas_upshifts" /id="D924" /incds=1 /nref=3 /ntot=100 /MaxReadThrough="1.93338" /MaxDrop="2.7192" /score="27.1353816" /energy="-13.5" /TU="NA" /idTUdmin="U1366" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1692695..1692702 /Source="Nicolas_upshift_promotors" /id="U1365" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=478 /SigmaFactorBS="tcatggttcctccgtataacaaaatttcCATTTACAggcaat tgggattaATGTATATTTTGGGTGAGGGggtggaaacatatggcatgtggtccgaaga t" /listShort="S612" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1692717..1692736 /Source="Nicolas_upshift_promotors" /id="U1365" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=478 /SigmaFactorBS="tcatggttcctccgtataacaaaatttcCATTTACAggcaat tgggattaATGTATATTTTGGGTGAGGGggtggaaacatatggcatgtggtccgaaga t" /listShort="S612" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1692727..1692860 /Source="Nicolas_S_feature" /locus_tag="new_1780399_1780532" /HighExp="LoTm, T0.30H, T1.30H, M9-stat, T3.0H, BC, T1.0H, B60, B36, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99494800000000005" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S612" upshifts 1692727 /Source="Nicolas_upshifts" /id="U1365" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=478 /SigmaFactorBS="tcatggttcctccgtataacaaaatttcCATTTACAggcaat tgggattaATGTATATTTTGGGTGAGGGggtggaaacatatggcatgtggtccgaaga t" /listShort="S612" /GFF_Attribute="listLong" /label="upshifts" misc_RNA complement(1692732..1692882) /gene="surX" /locus_tag="BSU_misc_RNA_89" /product="small untranslated RNA of unknown function" /note="Evidence 5: Unknown function; PubMedId : 20525796, 23155385" /label="surX RNA" gene complement(1692732..1692882) /gene="surX" /locus_tag="BSU_misc_RNA_89" /label="surX gene" downshifts 1692817 /Source="Nicolas_upshifts" /id="D925" /incds=0 /nref=19 /ntot=136 /MaxReadThrough="3.45962" /MaxDrop="4.12444" /score="29.4045648" /energy="-15.3" /TU="U1365" /idTUdmin="U1364" /TUdmin=354 /isTUend="FALSE" /label="downshifts" CDS complement(1692946..1693401) /gene="ymzD" /locus_tag="BSU_17060" /old_locus_tag="BSU17060" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="YP_054578.1" /db_xref="EnsemblGenomes-Gn:BSU17060" /db_xref="EnsemblGenomes-Tr:CAE01453" /db_xref="GOA:Q7WY71" /db_xref="InterPro:IPR025912" /db_xref="SubtiList:BG14188" /db_xref="UniProtKB/Swiss-Prot:Q7WY71" /translation="MNQKEQNEHSKDFNLRSKLIGIVSITFIAAIALAVIFGGFFFGM KGLFSILGITYASNQTLALFILACFAVGLIIDPLTKIISIILAKSLSLKKTALFAFIL YFISNLITICFADYFMQSIYIPDVLLVVISAFMAIIELAFDNQPNREAA*" /label="ymzD CDS" gene complement(1692946..1693401) /gene="ymzD" /locus_tag="BSU_17060" /old_locus_tag="BSU17060" /label="ymzD gene" S_feature complement(1693402..1693493) /Source="Nicolas_S_feature" /locus_tag="new_1781074_1781165_c" /HighExp="LBGstat, M9-stat, T1.0H, T1.30H, T2.0H, M0t90, MG 150, LPhT, T3.0H, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S613" promotor_-10 complement(1693481..1693500) /Source="Nicolas_upshift_promotors" /id="U1366" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.537462537462537" /psig="0.999000999001" /xcortree=3231 /SigmaFactorBS="tgatgaaaaaggcccttccccagtggaaagggcCTTTtttgg ttttgttaaaaTATGCTATACTATTTTCGTCagaaaacagacttatagatattttggg c" /listShort="S613, ymzD, S611" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1693493) /Source="Nicolas_upshifts" /id="U1366" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.537462537462537" /psig="0.999000999001" /xcortree=3231 /SigmaFactorBS="tgatgaaaaaggcccttccccagtggaaagggcCTTTtttgg ttttgttaaaaTATGCTATACTATTTTCGTCagaaaacagacttatagatattttggg c" /listShort="S613, ymzD, S611" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1693517..1693520) /Source="Nicolas_upshift_promotors" /id="U1366" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.537462537462537" /psig="0.999000999001" /xcortree=3231 /SigmaFactorBS="tgatgaaaaaggcccttccccagtggaaagggcCTTTtttgg ttttgttaaaaTATGCTATACTATTTTCGTCagaaaacagacttatagatattttggg c" /listShort="S613, ymzD, S611" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1693556..1694113) /gene="ymcC" /locus_tag="BSU_17070" /old_locus_tag="BSU17070" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_389588.1" /db_xref="EnsemblGenomes-Gn:BSU17070" /db_xref="EnsemblGenomes-Tr:CAB13579" /db_xref="GOA:O31780" /db_xref="SubtiList:BG13419" /db_xref="UniProtKB/Swiss-Prot:O31780" /translation="MNGIAWMIVFCEIAFWVVIVLGLAVRYVFKRHTLGLLFLALTPV IDLILLAATGVDLYRGASATAAHGIAAVYIGISIAYGKQMIQWADEKFQYYVTKKGTK PLKRFGMDHAKHGAKGWLRHVLAYLIGAGLLAGMIYFINDSSRTEALSGILKLWTVII GIDFLITASYFIWPKKEKASANLRS*" /label="ymcC CDS" gene complement(1693556..1694113) /gene="ymcC" /locus_tag="BSU_17070" /old_locus_tag="BSU17070" /label="ymcC gene" SCAR 1694204..1694205 /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs08" downshifts complement(1694256) /Source="Nicolas_upshifts" /id="D929" /incds=0 /nref=24 /ntot=184 /MaxReadThrough="3.69744" /MaxDrop="5.18486" /score="-0.71313204" /energy="-20.1" /TU="U1374" /idTUdmin="U1375" /TUdmin=28 /isTUend="FALSE" /label="downshifts" CDS complement(1694262..1694618) /gene="ymzB" /locus_tag="BSU_17240" /old_locus_tag="BSU17240" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11544224, 15805528, 20817675" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function involved in ethanol resistance" /protein_id="NP_389606.3" /db_xref="EnsemblGenomes-Gn:BSU17240" /db_xref="EnsemblGenomes-Tr:CAB13608" /db_xref="SubtiList:BG13435" /db_xref="UniProtKB/Swiss-Prot:O31786" /translation="MAHTNTQLSQWLESKVGQTLDIRKGELTHDEEISDLDQIVLHLQ KVAIRSTNHPDDYVAKEELVLEGEGTTFTEDGNVPLPQNAYEIPLLGELHIHQENEGL KVVTDRAVYTIDIQHS*" /label="ymzB CDS" gene complement(1694262..1694618) /gene="ymzB" /locus_tag="BSU_17240" /old_locus_tag="BSU17240" /label="ymzB gene" misc_feature complement(1694678..1694691) /Source="Nicolas_upshift_promotors" /id="U1374" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.511488511488511" /psig="0.121878121878122" /xcortree=731 /SigmaFactorBS="ccgtacgctatatcaaggcactcaacagcgaactgtttcata cataaagagtGGGGCGGCTCTTTCccgtgtaaaagatgcagcaattgggaatagtatc g" /listShort="ymzB, S618, pksS" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1694683) /Source="Nicolas_upshifts" /id="U1374" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.511488511488511" /psig="0.121878121878122" /xcortree=731 /SigmaFactorBS="ccgtacgctatatcaaggcactcaacagcgaactgtttcata cataaagagtGGGGCGGCTCTTTCccgtgtaaaagatgcagcaattgggaatagtatc g" /listShort="ymzB, S618, pksS" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1694697..1695521) /gene="ymaE" /locus_tag="BSU_17250" /old_locus_tag="BSU17250" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20817675; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_389607.2" /db_xref="EnsemblGenomes-Gn:BSU17250" /db_xref="EnsemblGenomes-Tr:CAB13609" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG13413" /db_xref="UniProtKB/Swiss-Prot:O31787" /translation="MPYYICNTCGVQHAQTVDPPNSCLICEDERQYIHPDGQTWTTLE DMREKGNLQNILKKEEEHLYSIKTEPEFAIGQTAHLIQHKGFNVLWDCMTYLDQKTID QINELGGIQAIALSHPHYYSTQVEWAEAFQAPIYIHEDDKEWVTRPSNHIHFWSGETL NMKPGLDLYRLGGHFKGGAVLHWSKGNEGKGCLLTGDIITVAADRNWVSFMYSYPNLI PLPASKVEEIAAKVKPLQFNRLYNAFSKVVKENADESVQRSAVRYIKALNSELFHT*" /label="ymaE CDS" gene complement(1694697..1695521) /gene="ymaE" /locus_tag="BSU_17250" /old_locus_tag="BSU17250" /label="ymaE gene" promotor_-10 complement(1695543..1695562) /Source="Nicolas_upshift_promotors" /id="U1375" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.88011988011988" /psig="0.992007992007992" /xcortree=2946 /SigmaFactorBS="gccggcaattctctctcagcagaactgccggttttttcgTTT GAATattcataatcaTAAGGTAAAATAATGGAAAAtagatgaaggaagtgaagaaagt g" /listShort="ymaE, ymzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1695559) /Source="Nicolas_upshifts" /id="U1375" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.88011988011988" /psig="0.992007992007992" /xcortree=2946 /SigmaFactorBS="gccggcaattctctctcagcagaactgccggttttttcgTTT GAATattcataatcaTAAGGTAAAATAATGGAAAAtagatgaaggaagtgaagaaagt g" /listShort="ymaE, ymzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1695574..1695580) /Source="Nicolas_upshift_promotors" /id="U1375" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.88011988011988" /psig="0.992007992007992" /xcortree=2946 /SigmaFactorBS="gccggcaattctctctcagcagaactgccggttttttcgTTT GAATattcataatcaTAAGGTAAAATAATGGAAAAtagatgaaggaagtgaagaaagt g" /listShort="ymaE, ymzB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1695632..1696960) /gene="aprX" /locus_tag="BSU_17260" /old_locus_tag="BSU17260" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10589719, 16267290, 17884659, 28693413" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10589719, 16267290, 17884659, 28693413; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alkaline serine protease" /protein_id="NP_389608.1" /db_xref="EnsemblGenomes-Gn:BSU17260" /db_xref="EnsemblGenomes-Tr:CAB13610" /db_xref="GOA:O31788" /db_xref="InterPro:IPR000209" /db_xref="InterPro:IPR015500" /db_xref="InterPro:IPR022398" /db_xref="InterPro:IPR023827" /db_xref="InterPro:IPR023828" /db_xref="InterPro:IPR036852" /db_xref="SubtiList:BG12567" /db_xref="UniProtKB/Swiss-Prot:O31788" /translation="MFGYSMVQMVRANAHKLDWPLRETVLQLYKPFKWTPCFLHKFFE TKLQNRKKMSVIIEFEEGCHETGFQMAGEVLQKEKRSKLKSRFNKINCCSAEVTPSAL HSLLSECSNIRKVYLNREVKALLDTATEASHAKEVVRNGQTLTGKGVTVAVVDTGIYP HPDLEGRIIGFADMVNQKTEPYDDNGHGTHCAGDVASSGASSSGQYRGPAPEANLIGV KVLNKQGSGTLADIIEGVEWCIQYNEDNPDEPIDIMSMSLGGDALRYDHEQEDPLVRA VEEAWSAGIVVCVAAGNSGPDSQTIASPGVSEKVITVGALDDNNTASSDDDTVASFSS RGPTVYGKEKPDILAPGVNIISLRSPNSYIDKLQKSSRVGSQYFTMSGTSMATPICAG IAALILQQNPDLTPDEVKELLKNGTDKWKDEDPNIYGAGAVNAENSVPGQ*" /label="aprX CDS" gene complement(1695632..1696960) /gene="aprX" /locus_tag="BSU_17260" /old_locus_tag="BSU17260" /label="aprX gene" downshifts complement(1695639) /Source="Nicolas_upshifts" /id="D930" /incds=0 /nref=13 /ntot=21 /MaxReadThrough="2.43809" /MaxDrop="5.8915" /score="10.5332562" /energy="-13" /TU="NA" /idTUdmin="U1376" /TUdmin=8 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1696983..1697002) /Source="Nicolas_upshift_promotors" /id="U1376" /multdbtbs="SigA" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1433 /SigmaFactorBS="aaaacaaactcttgtctgtctcttacagaggacaaacaAACT TACCAaacctatcatctgTTCATAGAGTATACAGAGAAccttataataggaggaaaat a" /listShort="aprX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1697002) /Source="Nicolas_upshifts" /id="U1376" /multdbtbs="SigA" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1433 /SigmaFactorBS="aaaacaaactcttgtctgtctcttacagaggacaaacaAACT TACCAaacctatcatctgTTCATAGAGTATACAGAGAAccttataataggaggaaaat a" /listShort="aprX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1697016..1697024) /Source="Nicolas_upshift_promotors" /id="U1376" /multdbtbs="SigA" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1433 /SigmaFactorBS="aaaacaaactcttgtctgtctcttacagaggacaaacaAACT TACCAaacctatcatctgTTCATAGAGTATACAGAGAAccttataataggaggaaaat a" /listShort="aprX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1697117..1697124 /Source="Nicolas_upshift_promotors" /id="U1378" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.806193806193806" /psig="0.999000999001" /xcortree=1507 /SigmaFactorBS="gatagattcagaagctgaggaaatcattgggGATTGAAAaag aacgtttgttcgTATTATAATGTGATCATATCaaactgggaaggggagagcaaccgta t" /listShort="ymzE, ymzE, S619, ymaC, ymaD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1697132..1697151) /Source="Nicolas_upshift_promotors" /id="U1377" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.753246753246753" /psig="0.999000999001" /xcortree=1500 /SigmaFactorBS="ggtgcaagtagaaattcatacggttgctctccCCTTCCCAgt ttgatatgatCACATTATAATACGAACAAAcgttctttttcaatccccaatgatttcc t" /listShort="aprX" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 1697140..1697159 /Source="Nicolas_upshift_promotors" /id="U1378" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.806193806193806" /psig="0.999000999001" /xcortree=1507 /SigmaFactorBS="gatagattcagaagctgaggaaatcattgggGATTGAAAaag aacgtttgttcgTATTATAATGTGATCATATCaaactgggaaggggagagcaaccgta t" /listShort="ymzE, ymzE, S619, ymaC, ymaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1697143) /Source="Nicolas_upshifts" /id="U1377" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.753246753246753" /psig="0.999000999001" /xcortree=1500 /SigmaFactorBS="ggtgcaagtagaaattcatacggttgctctccCCTTCCCAgt ttgatatgatCACATTATAATACGAACAAAcgttctttttcaatccccaatgatttcc t" /listShort="aprX" /GFF_Attribute="listLong" /label="upshifts" upshifts 1697146 /Source="Nicolas_upshifts" /id="U1378" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.806193806193806" /psig="0.999000999001" /xcortree=1507 /SigmaFactorBS="gatagattcagaagctgaggaaatcattgggGATTGAAAaag aacgtttgttcgTATTATAATGTGATCATATCaaactgggaaggggagagcaaccgta t" /listShort="ymzE, ymzE, S619, ymaC, ymaD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1697164..1697171) /Source="Nicolas_upshift_promotors" /id="U1377" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.753246753246753" /psig="0.999000999001" /xcortree=1500 /SigmaFactorBS="ggtgcaagtagaaattcatacggttgctctccCCTTCCCAgt ttgatatgatCACATTATAATACGAACAAAcgttctttttcaatccccaatgatttcc t" /listShort="aprX" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1697185..1697262 /gene="ymzEn" /locus_tag="BSU_17266" /old_locus_tag="BSU17266" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; N-terminal part of YmzE" /translation="MNFYLHRSLESQMPISIIYEERRND*" /label="ymzEn CDS" gene 1697185..1697262 /gene="ymzEn" /locus_tag="BSU_17266" /old_locus_tag="BSU17266" /pseudo /label="ymzEn gene" downshifts complement(1697187) /Source="Nicolas_upshifts" /id="D931" /incds=0 /nref=4 /ntot=7 /MaxReadThrough="1.51659" /MaxDrop="5.37668" /score="10.5332562" /energy="-13" /TU="NA" /idTUdmin="U1377" /TUdmin="-462" /isTUend="FALSE" /label="downshifts" CDS 1697240..1697416 /gene="ymzEc" /locus_tag="BSU_17267" /old_locus_tag="BSU17267" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; C-terminal part of YmzE" /db_xref="PSEUDO:CAX52622.1" /translation="MKKDGTISKRTIIVRQKSKTKIKAFCFSKQQIRTFLLDSILSCD FVRTNKQNLYSAGR*" /label="ymzEc CDS" gene 1697240..1697416 /gene="ymzEc" /locus_tag="BSU_17267" /old_locus_tag="BSU17267" /pseudo /label="ymzEc gene" downshifts 1697397 /Source="Nicolas_upshifts" /id="D932" /incds=0 /nref=42 /ntot=207 /MaxReadThrough="4.03151" /MaxDrop="6.55778" /score="-0.929304655" /energy="-5.5" /TU="U1378" /idTUdmin="U1378" /TUdmin="-1496" /isTUend="FALSE" /label="downshifts" S_feature 1697442..1697630 /Source="Nicolas_S_feature" /locus_tag="new_1863194_1863382" /HighExp="H2O2, M40t90, C90, M40t45, C30, S8, HiOs, G135, T-4.40H, T-5.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S619" misc_feature 1697625..1697644 /Source="Nicolas_upshift_promotors" /id="U1379" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.44955044955045" /psig=1 /xcortree=2371 /SigmaFactorBS="atcaattgattttttgaaaccgggaactttttcactgatgat attgtgtatacAATGGTAAGATAAAACCTATtggctaaacctcatataatgaaccgcg c" /listShort="ymaC, ymaD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1697632 /Source="Nicolas_upshifts" /id="U1379" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.44955044955045" /psig=1 /xcortree=2371 /SigmaFactorBS="atcaattgattttttgaaaccgggaactttttcactgatgat attgtgtatacAATGGTAAGATAAAACCTATtggctaaacctcatataatgaaccgcg c" /listShort="ymaC, ymaD" /GFF_Attribute="listLong" /label="upshifts" CDS 1697696..1698403 /gene="pghC" /locus_tag="BSU_17270" /old_locus_tag="BSU17270" /EC_number="3.4.19.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 16267290, 26158264; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="gamma-polyglutamate hydrolase (phage origin)" /protein_id="NP_389609.1" /db_xref="EnsemblGenomes-Gn:BSU17270" /db_xref="EnsemblGenomes-Tr:CAB13611" /db_xref="GOA:O31789" /db_xref="InterPro:IPR008585" /db_xref="SubtiList:BG13411" /db_xref="UniProtKB/Swiss-Prot:O31789" /translation="MRRFLLNVILVLAIVLFLRYVHYSLEPEPSNQPDTYSNFSSLAE NESPADYDISYNEKKGSKVLIMSPHGGRIEGGVSELVRYFNNEYSTYLFEGLKSHDNQ TLHITSTNFDEPLAKKKIKEHQYVVAFHGYKGENKNTLVGGTDRKRAKMIVRALERRG FSAELASSKSGLAGLNAENINNQGETGLSIQLEISREQREAFFDDFYYKNRKYTKNSE FYAYVSAIKGVLEKEYS*" /label="pghC CDS" gene 1697696..1698403 /gene="pghC" /locus_tag="BSU_17270" /old_locus_tag="BSU17270" /label="pghC gene" promotor_-35 1698414..1698420 /Source="Nicolas_upshift_promotors" /id="U1380" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.377622377622378" /psig="0.843156843156843" /xcortree=1826 /SigmaFactorBS="gtgtcctggaaaaagagtattcgtaacaagcagatcAGAAGA CaaaataagagaagATCAGTAGACTGAAATAGGAtaaaaaaggaggcaaaacaatggc a" /listShort="ymaD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1698434..1698453 /Source="Nicolas_upshift_promotors" /id="U1380" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.377622377622378" /psig="0.843156843156843" /xcortree=1826 /SigmaFactorBS="gtgtcctggaaaaagagtattcgtaacaagcagatcAGAAGA CaaaataagagaagATCAGTAGACTGAAATAGGAtaaaaaaggaggcaaaacaatggc a" /listShort="ymaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1698438 /Source="Nicolas_upshifts" /id="U1380" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.377622377622378" /psig="0.843156843156843" /xcortree=1826 /SigmaFactorBS="gtgtcctggaaaaagagtattcgtaacaagcagatcAGAAGA CaaaataagagaagATCAGTAGACTGAAATAGGAtaaaaaaggaggcaaaacaatggc a" /listShort="ymaD" /GFF_Attribute="listLong" /label="upshifts" CDS 1698473..1698925 /gene="ymaD" /locus_tag="BSU_17280" /old_locus_tag="BSU17280" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16267290, 22904090, 25649915; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative peroxiredoxin-related protein" /protein_id="NP_389610.1" /db_xref="EnsemblGenomes-Gn:BSU17280" /db_xref="EnsemblGenomes-Tr:CAB13612" /db_xref="InterPro:IPR003718" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR019905" /db_xref="InterPro:IPR036102" /db_xref="SubtiList:BG13412" /db_xref="UniProtKB/Swiss-Prot:O31790" /translation="MADHHFYLKANWPGNRNDVGTIESGNLITSISIPKEMDGPGEGT NPDEMLLGAAATCYIITLAAMMERSGLEKEDLQMESEGIVNVTKGVFTYKKIIHRPSV VLKHDASQDDVALAHKLCKKAESSCMISRAIQGNVELQLEASVKLGGE*" /label="ymaD CDS" gene 1698473..1698925 /gene="ymaD" /locus_tag="BSU_17280" /old_locus_tag="BSU17280" /label="ymaD gene" downshifts 1698913 /Source="Nicolas_upshifts" /id="D933" /incds=0 /nref=44 /ntot=182 /MaxReadThrough="1.35366" /MaxDrop="6.07534" /score="17.0193804" /energy="-12.1" /TU="NA" /idTUdmin="U1379" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(1698939..1699292) /gene="ebrB" /locus_tag="BSU_17290" /old_locus_tag="BSU17290" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10735876, 15849754, 16750162, 16850406, 18024586, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10735876, 15849754, 16750162, 16850406, 18024586, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="small toxic metabolite efflux transporter subunit" /protein_id="NP_389611.1" /db_xref="EnsemblGenomes-Gn:BSU17290" /db_xref="EnsemblGenomes-Tr:CAB13613" /db_xref="GOA:P0CW82" /db_xref="InterPro:IPR000390" /db_xref="SubtiList:BG12586" /db_xref="UniProtKB/Swiss-Prot:P0CW82" /translation="MRGLLYLALAIVSEVFGSTMLKLSEGFTQAWPIAGVIVGFLSAF TFLSFSLKTIDLSSAYATWSGVGTALTAIVGFLLFGETISLKGVFGLTLVIAGVVVLN QSKAHAEDKKQTACE*" /label="ebrB CDS" gene complement(1698939..1699292) /gene="ebrB" /locus_tag="BSU_17290" /old_locus_tag="BSU17290" /label="ebrB gene" downshifts complement(1698980) /Source="Nicolas_upshifts" /id="D934" /incds=0 /nref=2 /ntot=45 /MaxReadThrough="0.84905" /MaxDrop="2.87924" /score="-2.89884673" /energy="-8.7" /TU="NA" /idTUdmin="U1381" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" CDS complement(1699306..1699623) /gene="ebrA" /locus_tag="BSU_17300" /old_locus_tag="BSU17300" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10735876, 11104814, 17516673, 18024586" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10735876, 11104814, 17516673, 18024586; Product type t: transporter" /codon_start=1 /transl_table=11 /product="small toxic metabolite efflux transporter subunit" /protein_id="NP_389612.1" /db_xref="EnsemblGenomes-Gn:BSU17300" /db_xref="EnsemblGenomes-Tr:CAB13614" /db_xref="GOA:P0CW80" /db_xref="InterPro:IPR000390" /db_xref="SubtiList:BG12585" /db_xref="UniProtKB/Swiss-Prot:P0CW80" /translation="MLIGYIFLTIAICSESIGAAMLKVSDGFKKWKPSALVVIGYSLA FYMLSLTLNHIPLSLSYATWSGAGTVLTTVIGVKWFKEDLNAKGLIGILLLLSGVVLL NWP*" /label="ebrA CDS" gene complement(1699306..1699623) /gene="ebrA" /locus_tag="BSU_17300" /old_locus_tag="BSU17300" /label="ebrA gene" promotor_-10 complement(1699667..1699686) /Source="Nicolas_upshift_promotors" /id="U1381" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.843156843156843" /psig="0.998001998001998" /xcortree=1863 /SigmaFactorBS="gtctttttaagtgtgtgaaaatgaatcTCTTGACTcatacat aggcataCACTAATATTTTTCTAGCTGaagttttttttctaatctaaaaatatagtga g" /listShort="ebrA, ebrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1699675) /Source="Nicolas_upshifts" /id="U1381" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.843156843156843" /psig="0.998001998001998" /xcortree=1863 /SigmaFactorBS="gtctttttaagtgtgtgaaaatgaatcTCTTGACTcatacat aggcataCACTAATATTTTTCTAGCTGaagttttttttctaatctaaaaatatagtga g" /listShort="ebrA, ebrB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1699701..1699708) /Source="Nicolas_upshift_promotors" /id="U1381" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.843156843156843" /psig="0.998001998001998" /xcortree=1863 /SigmaFactorBS="gtctttttaagtgtgtgaaaatgaatcTCTTGACTcatacat aggcataCACTAATATTTTTCTAGCTGaagttttttttctaatctaaaaatatagtga g" /listShort="ebrA, ebrB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1699760..1700035) /gene="ymaG" /locus_tag="BSU_17310" /old_locus_tag="BSU17310" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 19775244, 19933362, 22882546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 19775244, 19933362, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="inner spore coat protein; cell wall associated protein" /protein_id="NP_389613.2" /db_xref="EnsemblGenomes-Gn:BSU17310" /db_xref="EnsemblGenomes-Tr:CAB13615" /db_xref="GOA:O31793" /db_xref="SubtiList:BG13415" /db_xref="UniProtKB/Swiss-Prot:O31793" /translation="MNELEHFSPEDTRIFGRPFGFGRPFGFGRPFGFGYGFGRPGFGY GFGRPFGFFGGPFIGGLAGGLIGSALFNPYLYGGYPYYPYAPFPFYY*" /label="ymaG CDS" gene complement(1699760..1700035) /gene="ymaG" /locus_tag="BSU_17310" /old_locus_tag="BSU17310" /label="ymaG gene" downshifts complement(1699761) /Source="Nicolas_upshifts" /id="D935" /incds=0 /nref=38 /ntot=44 /MaxReadThrough="0.28059" /MaxDrop="8.33353" /score="12.3408391" /energy="-11.5" /TU="NA" /idTUdmin="U1383" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1700031..1700036 /Source="Nicolas_upshift_promotors" /id="U1382" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=1027 /SigmaFactorBS="gctgaaatgctctaactcgTTCATGttttctttcctcctgTA ATAAAGTGTAGATGATGcagtgtattcaccctgcccggatttgattgggcgaatcgag g" /listShort="ymaF, miaA, ymaH" /listLong="ymzC" /label="promotor_-35" promotor_-10 1700052..1700070 /Source="Nicolas_upshift_promotors" /id="U1382" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=1027 /SigmaFactorBS="gctgaaatgctctaactcgTTCATGttttctttcctcctgTA ATAAAGTGTAGATGATGcagtgtattcaccctgcccggatttgattgggcgaatcgag g" /listShort="ymaF, miaA, ymaH" /listLong="ymzC" /label="promotor_-10" promotor_-10 complement(1700062..1700081) /Source="Nicolas_upshift_promotors" /id="U1383" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1298 /SigmaFactorBS="caatgtgttcacatcctccttttcctcgattcGCCCAATCAA atccgggcagggTGAATACACTGCATCATCTAcactttattacaggaggaaagaaaac a" /listShort="ymaG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1700072 /Source="Nicolas_upshifts" /id="U1382" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=1027 /SigmaFactorBS="gctgaaatgctctaactcgTTCATGttttctttcctcctgTA ATAAAGTGTAGATGATGcagtgtattcaccctgcccggatttgattgggcgaatcgag g" /listShort="ymaF, miaA, ymaH" /listLong="ymzC" /label="upshifts" upshifts complement(1700075) /Source="Nicolas_upshifts" /id="U1383" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1298 /SigmaFactorBS="caatgtgttcacatcctccttttcctcgattcGCCCAATCAA atccgggcagggTGAATACACTGCATCATCTAcactttattacaggaggaaagaaaac a" /listShort="ymaG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1700094..1700103) /Source="Nicolas_upshift_promotors" /id="U1383" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1298 /SigmaFactorBS="caatgtgttcacatcctccttttcctcgattcGCCCAATCAA atccgggcagggTGAATACACTGCATCATCTAcactttattacaggaggaaagaaaac a" /listShort="ymaG" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1700124..1700537 /gene="ymaF" /locus_tag="BSU_17320" /old_locus_tag="BSU17320" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 24098137, 25915524" /codon_start=1 /transl_table=11 /product="putative sporulation-related protein of unknown function" /protein_id="NP_389614.2" /db_xref="EnsemblGenomes-Gn:BSU17320" /db_xref="EnsemblGenomes-Tr:CAB13616" /db_xref="InterPro:IPR024307" /db_xref="SubtiList:BG13414" /db_xref="UniProtKB/Swiss-Prot:O31794" /translation="MNTLGLYQSDWSKAPPHAHAYHVKTTREQGHYHLIEGFTQPANG SNTDQHTHYYTGITSFENGHFHRYYGISGPAIPLADGTHYHEIEETTYLAYNEPIEIQ YGGVVYDPGDDRRKTHRHTLKGKTREIVGNEPLGW*" /label="ymaF CDS" gene 1700124..1700537 /gene="ymaF" /locus_tag="BSU_17320" /old_locus_tag="BSU17320" /label="ymaF gene" upshifts 1700588 /Source="Nicolas_upshifts" /id="U1384" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.786213786213786" /psig="0.883116883116883" /xcortree=2366 /SigmaFactorBS="cggctggtagaaggatgtttaccgatgcaaaaaaagggcaaa atggataggtggttgtccatgttgAATGCTATAATGGGGGGAGAtttataaaagagag t" /listShort="miaA, ymaH" /listLong="ymzC, ymzA, S620, S621, nrdI, nrdE, nrdF, ymaB" /label="upshifts" misc_feature 1700594..1700613 /Source="Nicolas_upshift_promotors" /id="U1384" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.786213786213786" /psig="0.883116883116883" /xcortree=2366 /SigmaFactorBS="cggctggtagaaggatgtttaccgatgcaaaaaaagggcaaa atggataggtggttgtccatgttgAATGCTATAATGGGGGGAGAtttataaaagagag t" /listShort="miaA, ymaH" /listLong="ymzC, ymzA, S620, S621, nrdI, nrdE, nrdF, ymaB" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 1700637..1701581 /gene="miaA" /locus_tag="BSU_17330" /old_locus_tag="BSU17330" /EC_number="2.5.1.75" /function="16.3: Control" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 3045085, 11160115, 26735940, 28277934, 28471404; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA isopentenylpyrophosphate transferase" /protein_id="NP_389615.2" /db_xref="EnsemblGenomes-Gn:BSU17330" /db_xref="EnsemblGenomes-Tr:CAB13617" /db_xref="GOA:O31795" /db_xref="InterPro:IPR018022" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12617" /db_xref="UniProtKB/Swiss-Prot:O31795" /translation="MNNTKQPVVILVGPTAVGKTNLSIQLAKSLNAEIISGDSMQIYK GMDIGTAKITEQEMEGVPHHLIDILDPQDSFSTADYQSLVRNKISEIANRGKLPMIVG GTGLYIQSVLYDYTFTEEANDPVFRESMQMAAEREGADFLHAKLAAADPEAAAAIHPN NTRRVIRALEILHTSGKTMSQHLKEQKRELLYNAVLIGLTMDRDTLYERINQRVDLMM QSGLLPEVKRLYDKNVRDCQSIQAIGYKELYAYFDGFVTLSDAVEQLKQNSRRYAKRQ LTWFRNKMQVTWFDMTPPVDMELKKKEIFTHIAGKLEL*" /label="miaA CDS" gene 1700637..1701581 /gene="miaA" /locus_tag="BSU_17330" /old_locus_tag="BSU17330" /label="miaA gene" promotor_-35 1701561..1701569 /Source="Nicolas_upshift_promotors" /id="U1385" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=547 /SigmaFactorBS="gatatggagctgaaaaaaaaggaaattttcacacatataGCA GGAAAActcgaactttAATCGAAACTGTATGATATagagaatcaaggaggacgaaaca t" /listShort="ymaH, ymzC, ymzA, S620, S621" /listLong="nrdI, nrdE, nrdF, ymaB" /label="promotor_-35" promotor_-10 1701580..1701598 /Source="Nicolas_upshift_promotors" /id="U1385" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=547 /SigmaFactorBS="gatatggagctgaaaaaaaaggaaattttcacacatataGCA GGAAAActcgaactttAATCGAAACTGTATGATATagagaatcaaggaggacgaaaca t" /listShort="ymaH, ymzC, ymzA, S620, S621" /listLong="nrdI, nrdE, nrdF, ymaB" /label="promotor_-10" upshifts 1701582 /Source="Nicolas_upshifts" /id="U1385" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=547 /SigmaFactorBS="gatatggagctgaaaaaaaaggaaattttcacacatataGCA GGAAAActcgaactttAATCGAAACTGTATGATATagagaatcaaggaggacgaaaca t" /listShort="ymaH, ymzC, ymzA, S620, S621" /listLong="nrdI, nrdE, nrdF, ymaB" /label="upshifts" CDS 1701621..1701842 /gene="hfq" /locus_tag="BSU_17340" /old_locus_tag="BSU17340" /function="16.3: Control" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16166525, 20445260, 22053080, 23457461, 24932523, 27049793, 27581927" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16166525, 20445260, 22053080, 23457461, 24932523, 27049793, 27581927; Product type f: factor" /codon_start=1 /transl_table=11 /product="Hfq RNA chaperone" /protein_id="NP_389616.1" /db_xref="EnsemblGenomes-Gn:BSU17340" /db_xref="EnsemblGenomes-Tr:CAB13618" /db_xref="GOA:O31796" /db_xref="InterPro:IPR005001" /db_xref="InterPro:IPR010920" /db_xref="PDB:3AHU" /db_xref="PDB:3HSB" /db_xref="SubtiList:BG13416" /db_xref="UniProtKB/Swiss-Prot:O31796" /translation="MKPINIQDQFLNQIRKENTYVTVFLLNGFQLRGQVKGFDNFTVL LESEGKQQLIYKHAISTFAPQKNVQLELE*" /label="hfq CDS" gene 1701621..1701842 /gene="hfq" /locus_tag="BSU_17340" /old_locus_tag="BSU17340" /label="hfq gene" downshifts complement(1701632) /Source="Nicolas_upshifts" /id="D936" /incds=0 /nref=3 /ntot=108 /MaxReadThrough="1.19472" /MaxDrop="3.56162" /score="-5.83707008" /energy="-5.2" /TU="NA" /idTUdmin="U1386" /TUdmin=22 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1701694..1701698) /Source="Nicolas_upshift_promotors" /id="U1386" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.998001998001998" /psig="0.000999000999001" /xcortree=46 /SigmaFactorBS="ttccaacaatacggtaaagttatcaaagcctttcacctggCC CCGCaactgaaagccgttCAGCAaaaaaacagtgacatacgtattttctttccggatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1701698) /Source="Nicolas_upshifts" /id="U1386" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.998001998001998" /psig="0.000999000999001" /xcortree=46 /SigmaFactorBS="ttccaacaatacggtaaagttatcaaagcctttcacctggCC CCGCaactgaaagccgttCAGCAaaaaaacagtgacatacgtattttctttccggatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1701713..1701718) /Source="Nicolas_upshift_promotors" /id="U1386" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.998001998001998" /psig="0.000999000999001" /xcortree=46 /SigmaFactorBS="ttccaacaatacggtaaagttatcaaagcctttcacctggCC CCGCaactgaaagccgttCAGCAaaaaaacagtgacatacgtattttctttccggatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1701842 /Source="Nicolas_upshifts" /id="D937" /incds=0 /nref=26 /ntot=212 /MaxReadThrough="5.10866" /MaxDrop="4.06475" /score="17.2354231" /energy="-17" /TU="U1382,U1385" /idTUdmin="U1384" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 1702038..1702310 /gene="ymzC" /locus_tag="BSU_17350" /old_locus_tag="BSU17350" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389617.1" /db_xref="EnsemblGenomes-Gn:BSU17350" /db_xref="EnsemblGenomes-Tr:CAB13619" /db_xref="InterPro:IPR025448" /db_xref="PDB:3KVP" /db_xref="SubtiList:BG13436" /db_xref="UniProtKB/Swiss-Prot:O31797" /translation="MFESEAELRRIRIALVWIAVFLLFGACGNQDTIIETDNGNSDYE TPQPTSFPLEHNHFGVMEDGYIKIYEYNESRNEVKLKKEYADDELE*" /label="ymzC CDS" gene 1702038..1702310 /gene="ymzC" /locus_tag="BSU_17350" /old_locus_tag="BSU17350" /label="ymzC gene" promotor_-35 1702326..1702333 /Source="Nicolas_upshift_promotors" /id="U1387" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.84015984015984" /psig=1 /xcortree=2039 /SigmaFactorBS="cgcggatgatgagcttgaataaaattcacaagcattcGAATT TACaaagcggatgccaGCCGCTAAACTAAATACAGAcacagatcaaacagagggtgaa a" /listShort="ymzA, S620, S621, nrdI, nrdE, nrdF, ymaB, S623" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1702347..1702366 /Source="Nicolas_upshift_promotors" /id="U1387" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.84015984015984" /psig=1 /xcortree=2039 /SigmaFactorBS="cgcggatgatgagcttgaataaaattcacaagcattcGAATT TACaaagcggatgccaGCCGCTAAACTAAATACAGAcacagatcaaacagagggtgaa a" /listShort="ymzA, S620, S621, nrdI, nrdE, nrdF, ymaB, S623" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1702349 /Source="Nicolas_upshifts" /id="U1387" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.84015984015984" /psig=1 /xcortree=2039 /SigmaFactorBS="cgcggatgatgagcttgaataaaattcacaagcattcGAATT TACaaagcggatgccaGCCGCTAAACTAAATACAGAcacagatcaaacagagggtgaa a" /listShort="ymzA, S620, S621, nrdI, nrdE, nrdF, ymaB, S623" /GFF_Attribute="listLong" /label="upshifts" CDS 1702392..1702622 /gene="ymzA" /locus_tag="BSU_17360" /old_locus_tag="BSU17360" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389618.1" /db_xref="EnsemblGenomes-Gn:BSU17360" /db_xref="EnsemblGenomes-Tr:CAB13620" /db_xref="SubtiList:BG13434" /db_xref="UniProtKB/Swiss-Prot:O31798" /translation="MKHKVIVNHWEEICEDDSCYEYGTSIIVNGKELIREASIITALK AVLEEIGADVEIEETVESEKCCDSLRKKNLDY*" /label="ymzA CDS" gene 1702392..1702622 /gene="ymzA" /locus_tag="BSU_17360" /old_locus_tag="BSU17360" /label="ymzA gene" S_feature 1702623..1702699 /Source="Nicolas_S_feature" /locus_tag="new_1868375_1868451" /HighExp="dia5, dia15, Diami, B60, G150, H2O2, LPhT, G180, G135, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH" /TUshortPSig="1, 0.999" /TUlongSig="SigA" /TUlongPSig="0.883" /label="S620" downshifts 1702656 /Source="Nicolas_upshifts" /id="D938" /incds=0 /nref=24 /ntot=61 /MaxReadThrough="7.47169" /MaxDrop="4.19691" /score="8.2587309" /energy="-16.9" /TU="U1385,U1387" /idTUdmin="U1385" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" S_feature 1702701..1702808 /Source="Nicolas_S_feature" /locus_tag="new_1868453_1868560" /HighExp="G180, G150, G135, H2O2, dia15, Paraq, LBGexp, C30, Diami, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH" /TUshortPSig="1, 0.999" /TUlongSig="SigA" /TUlongPSig="0.883" /label="S621" promotor_-35 1702781..1702788 /Source="Nicolas_upshift_promotors" /id="U1388" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.653346653346653" /psig=1 /xcortree=3005 /SigmaFactorBS="aatatgaatttttcataaaaacgaatctataTATTGTGTttt tgctagagggTAGTATACTATATATAGTGTtagtgatgagagattcatattttttgat a" /listShort="nrdI, nrdE, nrdF, ymaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1702802..1702821 /Source="Nicolas_upshift_promotors" /id="U1388" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.653346653346653" /psig=1 /xcortree=3005 /SigmaFactorBS="aatatgaatttttcataaaaacgaatctataTATTGTGTttt tgctagagggTAGTATACTATATATAGTGTtagtgatgagagattcatattttttgat a" /listShort="nrdI, nrdE, nrdF, ymaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1702810 /Source="Nicolas_upshifts" /id="U1388" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.653346653346653" /psig=1 /xcortree=3005 /SigmaFactorBS="aatatgaatttttcataaaaacgaatctataTATTGTGTttt tgctagagggTAGTATACTATATATAGTGTtagtgatgagagattcatattttttgat a" /listShort="nrdI, nrdE, nrdF, ymaB" /GFF_Attribute="listLong" /label="upshifts" CDS 1702865..1703257 /gene="nrdI" /locus_tag="BSU_17370" /old_locus_tag="BSU17370" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 16885274, 21561096, 22443445, 23402532, 26507228" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16885274, 21561096, 22443445, 23402532, 26507228; Product type f : factor" /codon_start=1 /transl_table=11 /product="co-factor of ribonucleotide diphosphate reductase" /protein_id="NP_389619.1" /db_xref="EnsemblGenomes-Gn:BSU17370" /db_xref="EnsemblGenomes-Tr:CAB13621" /db_xref="GOA:P50618" /db_xref="InterPro:IPR004465" /db_xref="InterPro:IPR020852" /db_xref="InterPro:IPR029039" /db_xref="PDB:1RLJ" /db_xref="SubtiList:BG11426" /db_xref="UniProtKB/Swiss-Prot:P50618" /translation="MVQIIFDSKTGNVQRFVNKTGFQQIRKVDEMDHVDTPFVLVTYT TNFGQVPASTQSFLEKYAHLLLGVAASGNKVWGDNFAKSADTISRQYQVPILHKFELS GTSKDVELFTQEVERVVTKSSAKMDPVK*" /label="nrdI CDS" gene 1702865..1703257 /gene="nrdI" /locus_tag="BSU_17370" /old_locus_tag="BSU17370" /label="nrdI gene" CDS 1703217..1705319 /gene="nrdE" /locus_tag="BSU_17380" /old_locus_tag="BSU17380" /EC_number="1.17.4.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15937154, 16885274, 17395719, 21561096, 22443445, 23402532, 24401092, 27920297" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15937154, 16885274, 17395719, 21561096, 22443445, 23402532, 24401092, 27920297; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonucleoside-diphosphate reductase (major subunit)" /protein_id="NP_389620.1" /db_xref="EnsemblGenomes-Gn:BSU17380" /db_xref="EnsemblGenomes-Tr:CAB13622" /db_xref="GOA:P50620" /db_xref="InterPro:IPR000788" /db_xref="InterPro:IPR008926" /db_xref="InterPro:IPR013346" /db_xref="InterPro:IPR013509" /db_xref="InterPro:IPR013554" /db_xref="InterPro:IPR026459" /db_xref="SubtiList:BG11404" /db_xref="UniProtKB/Swiss-Prot:P50620" /translation="MSQNQVPKWIQLNNEIMIQKDGKFQFDKDKEAVHSYFVDYINQN TVFFHNLKEKLDYLVENQYYEEEFLSLYSFEDIKEVFKTAYAKKFRFPSFMSAFKFYN DYALKTNDKKKILERYEDRISIVALFFANGDTEKAKEYVNLMINQEYQPSTPTFLNAG RKRRGELVSCFLLEVNDSLNDISRAIDISMQLSKLGGGVSLNLSKLRAKGEAIKDVEN ATKGVVGVMKLLDNAFRYADQMGQRQGSGAAYLNIFHRDINDFLDTKKISADEDVRVK TLSIGVVIPDKFVELAREDKAAYVFYPHTIYKEYGQHMDEMDMNEMYDKFVDNPRVKK EKINPRKLLEKLAMLRSESGYPYIMFQDNVNKVHANNHISKVKFSNLCSEVLQASQVS SYTDYDEEDEIGLDISCNLGSLNILNVMEHKSIEKTVKLATDSLTHVSETTDIRNAPA VRRANKAMKSIGLGAMNLHGYLAQNGIAYESPEARDFANTFFMMVNFYSIQRSAEIAK EKGETFDQYEGSTYATGEYFDKYVSTDFSPKYEKIANLFEGMHIPTTEDWKKLKAFVA EHGMYHSYRLCIAPTGSISYVQSSTASVMPIMERIEERTYGNSKTYYPMPGLASNNWF FYKEAYDMDMFKVVDMIATIQQHIDQGISFTLFLKDTMTTRDLNRIDLYAHHRGIKTI YYARTKDTGQDSCLSCVV*" /label="nrdE CDS" gene 1703217..1705319 /gene="nrdE" /locus_tag="BSU_17380" /old_locus_tag="BSU17380" /label="nrdE gene" CDS 1705337..1706326 /gene="nrdF" /locus_tag="BSU_17390" /old_locus_tag="BSU17390" /EC_number="1.17.4.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15937154, 16885274, 17395719, 21561096, 22443445, 23402532, 24401092, 27920297" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15937154, 16885274, 17395719, 21561096, 22443445, 23402532, 24401092, 27920297; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonucleoside-diphosphate reductase (minor subunit)" /protein_id="NP_389621.1" /db_xref="EnsemblGenomes-Gn:BSU17390" /db_xref="EnsemblGenomes-Tr:CAB13623" /db_xref="GOA:P50621" /db_xref="InterPro:IPR000358" /db_xref="InterPro:IPR009078" /db_xref="InterPro:IPR026494" /db_xref="InterPro:IPR030475" /db_xref="InterPro:IPR033909" /db_xref="PDB:4DR0" /db_xref="SubtiList:BG11405" /db_xref="UniProtKB/Swiss-Prot:P50621" /translation="MTKIYDAANWSKHEDDFTQMFYNQNVKQFWLPEEIALNGDLLTW KYLGKNEQDTYMKVLAGLTLLDTEQGNTGMPIVAEHVDGHQRKAVLNFMAMMENAVHA KSYSNIFMTLAPTETINEVFEWVKQNKYLQKKAQMIVGLYKAIQKDDEISLFKAMVAS VYLESFLFYSGFYYPLYFYGQGKLMQSGEIINLILRDEAIHGVYVGLLAQEIYNKQTE EKKAELREFAIDLLNQLYENELEYTEDLYDQVGLSHDVKKFIRYNANKALMNLGFDPY FEEEDINPIVLNGLNTKTKSHDFFSMKGNGYKKATVEPLKDDDFYFEDEKEQI*" /label="nrdF CDS" gene 1705337..1706326 /gene="nrdF" /locus_tag="BSU_17390" /old_locus_tag="BSU17390" /label="nrdF gene" downshifts 1706286 /Source="Nicolas_upshifts" /id="D939" /incds=0 /nref=3 /ntot=106 /MaxReadThrough="6.49299" /MaxDrop="2.8143" /score="-8.26008921" /energy="-10.8" /TU="U1387,U1388" /idTUdmin="U1388" /TUdmin="-726" /isTUend="FALSE" /label="downshifts" S_feature complement(1706340..1706999) /Source="Nicolas_S_feature" /locus_tag="new_1872092_1872751_c" /HighExp="BT, B36, C30, Pyr, S8, G135, G/S, Glucon, B60, C90" /AntisenseName="ymaB" /AntisenseCor="-0.136438199650502" /AntisenseRegPval="-1.6" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S622" downshifts complement(1706355) /Source="Nicolas_upshifts" /id="D940" /incds=0 /nref=3 /ntot=8 /MaxReadThrough="2.78803" /MaxDrop="4.0424" /score="6.77419677" /energy="-10.8" /TU="NA" /idTUdmin="U1390" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS 1706376..1706996 /gene="ymaB" /locus_tag="BSU_17400" /old_locus_tag="BSU17400" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16885274, 21561096; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative cofactor involved in deoxyribonucleotide synthesis" /protein_id="NP_389622.1" /db_xref="EnsemblGenomes-Gn:BSU17400" /db_xref="EnsemblGenomes-Tr:CAB13624" /db_xref="GOA:P50619" /db_xref="InterPro:IPR015797" /db_xref="SubtiList:BG11427" /db_xref="UniProtKB/Swiss-Prot:P50619" /translation="MGKMDEMILVAPRDDVFKKESLTFQGVYSEDSRVAEIMAQIEAA YREMRRGDAEEDPRFKQPIPYVVIKREDEVFLYERLAGGGESRLHNKLSLGFGGHMNA IEGAASFAEVLKLNTDRELEEELQINEEDKQAIVTLGLINDDENSVGKVHIGILSALQ LKPGAQVEVKEKEQIAGKWMKVSELKQDDIYNRLETWSQFVVDILE*" /label="ymaB CDS" gene 1706376..1706996 /gene="ymaB" /locus_tag="BSU_17400" /old_locus_tag="BSU17400" /label="ymaB gene" downshifts 1706977 /Source="Nicolas_upshifts" /id="D941" /incds=0 /nref=130 /ntot=257 /MaxReadThrough="4.3301" /MaxDrop="6.0751" /score="31.3992458" /energy="-16.3" /TU="U1387,U1388" /idTUdmin="U1388" /TUdmin="-35" /isTUend="FALSE" /label="downshifts" promotor_-35 1707012..1707016 /Source="Nicolas_upshift_promotors" /id="U1389" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.631368631368631" /psig="0.230769230769231" /xcortree=1799 /SigmaFactorBS="ttgttgttgatattcttgaataaaaaaacccggtttctCGCG AtgaggagccgggtttttttatGAGACGCTCGTCCCCGTCtcggctatgattctagga t" /listShort="S623" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1707034..1707401 /Source="Nicolas_S_feature" /locus_tag="new_1872786_1873153" /HighExp="dia15, G180, H2O2, G135, G150, Diami, Paraq, Oxctl, LBGexp, C30" /AntisenseName="cwlC" /AntisenseCor="-8.9131707018362205E-2" /AntisenseRegPval="-0.8" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.231, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S623" upshifts 1707034 /Source="Nicolas_upshifts" /id="U1389" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.631368631368631" /psig="0.230769230769231" /xcortree=1799 /SigmaFactorBS="ttgttgttgatattcttgaataaaaaaacccggtttctCGCG AtgaggagccgggtttttttatGAGACGCTCGTCCCCGTCtcggctatgattctagga t" /listShort="S623" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1707038..1707055 /Source="Nicolas_upshift_promotors" /id="U1389" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.631368631368631" /psig="0.230769230769231" /xcortree=1799 /SigmaFactorBS="ttgttgttgatattcttgaataaaaaaacccggtttctCGCG AtgaggagccgggtttttttatGAGACGCTCGTCCCCGTCtcggctatgattctagga t" /listShort="S623" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(1707044) /Source="Nicolas_upshifts" /id="D942" /incds=0 /nref=1 /ntot=53 /MaxReadThrough="7.25519" /MaxDrop="4.6417" /score="9.14776993" /energy="-8.9" /TU="U1390" /idTUdmin="U1390" /TUdmin="-682" /isTUend="FALSE" /label="downshifts" CDS complement(1707060..1707827) /gene="cwlC" /locus_tag="BSU_17410" /old_locus_tag="BSU17410" /EC_number="3.5.1.28" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10515909, 10945275, 10974124, 11375403, 16042392" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10515909, 10945275, 10974124, 11375403, 16042392; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylmuramoyl-L-alanine amidase (sporulation-specific)" /protein_id="NP_389623.2" /db_xref="EnsemblGenomes-Gn:BSU17410" /db_xref="EnsemblGenomes-Tr:CAB13625" /db_xref="GOA:Q06320" /db_xref="InterPro:IPR002508" /db_xref="InterPro:IPR007730" /db_xref="InterPro:IPR036680" /db_xref="PDB:1X60" /db_xref="SubtiList:BG10825" /db_xref="UniProtKB/Swiss-Prot:Q06320" /translation="MVKIFIDPGHGGSDPGATGNGLQEKTLTLQIALALRTILTNEYE GVSLLLSRTSDQYVSLNDRTNAANNWGADFFLSIHVNSGGGTGFESYIYPDVGAPTTT YQSTIHSEVIQAVDFADRGKKTANFHVLRESAMPALLTENGFIDTVSDANKLKTSSFI QSLARGHANGLEQAFNLKKTSSSGLYKVQIGAFKVKANADSLASNAEAKGFDSIVLLK DGLYKVQIGAFSSKDNADTLAARAKNAGFDAIVILES*" /label="cwlC CDS" gene complement(1707060..1707827) /gene="cwlC" /locus_tag="BSU_17410" /old_locus_tag="BSU17410" /label="cwlC gene" promotor_-10 complement(1707836..1707855) /Source="Nicolas_upshift_promotors" /id="U1390" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1431 /SigmaFactorBS="tgtgaaagggttatttcctcatttttcagttgaatgataatc GTACAAGCAGaagccgtgttttTTCATATCCTGTAATGAGGTgatgaaaaatggttaa a" /listShort="cwlC, S622" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1707859) /Source="Nicolas_upshifts" /id="U1390" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1431 /SigmaFactorBS="tgtgaaagggttatttcctcatttttcagttgaatgataatc GTACAAGCAGaagccgtgttttTTCATATCCTGTAATGAGGTgatgaaaaatggttaa a" /listShort="cwlC, S622" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1707868..1707877) /Source="Nicolas_upshift_promotors" /id="U1390" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1431 /SigmaFactorBS="tgtgaaagggttatttcctcatttttcagttgaatgataatc GTACAAGCAGaagccgtgttttTTCATATCCTGTAATGAGGTgatgaaaaatggttaa a" /listShort="cwlC, S622" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1707981..1707986 /Source="Nicolas_upshift_promotors" /id="U1391" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.828171828171828" /psig="0.828171828171828" /xcortree=1459 /SigmaFactorBS="agcgcacaattcaacatgaagcgacaacagatacggtccGAC ATGaaatctgtgcatacgCCATATGTTTGTATGTACTatgggttcggttaacctgcac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1708002..1708020 /Source="Nicolas_upshift_promotors" /id="U1391" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.828171828171828" /psig="0.828171828171828" /xcortree=1459 /SigmaFactorBS="agcgcacaattcaacatgaagcgacaacagatacggtccGAC ATGaaatctgtgcatacgCCATATGTTTGTATGTACTatgggttcggttaacctgcac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1708002 /Source="Nicolas_upshifts" /id="U1391" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.828171828171828" /psig="0.828171828171828" /xcortree=1459 /SigmaFactorBS="agcgcacaattcaacatgaagcgacaacagatacggtccGAC ATGaaatctgtgcatacgCCATATGTTTGTATGTACTatgggttcggttaacctgcac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1708284..1708289 /Source="Nicolas_upshift_promotors" /id="U1392" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.777222777222777" /psig="0.777222777222777" /xcortree=1148 /SigmaFactorBS="tactctgacaaaatgattaaaaacaaaatctcatGGTTTGtc caccccatgtccgtGAATACAATAAGAAATAAAgtatttctcgggaaagcgcaggatt c" /listShort="S624, spoVK" /listLong="ynbA, ynbB" /label="promotor_-35" promotor_-10 1708306..1708324 /Source="Nicolas_upshift_promotors" /id="U1392" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.777222777222777" /psig="0.777222777222777" /xcortree=1148 /SigmaFactorBS="tactctgacaaaatgattaaaaacaaaatctcatGGTTTGtc caccccatgtccgtGAATACAATAAGAAATAAAgtatttctcgggaaagcgcaggatt c" /listShort="S624, spoVK" /listLong="ynbA, ynbB" /label="promotor_-10" S_feature 1708310..1708450 /Source="Nicolas_S_feature" /locus_tag="new_1874062_1874202" /HighExp="S4, S5, S6, S8, S3, B60, LoTm, S7, T5.0H, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.777" /TUlongSig="NA" /TUlongPSig="NA" /label="S624" upshifts 1708310 /Source="Nicolas_upshifts" /id="U1392" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.777222777222777" /psig="0.777222777222777" /xcortree=1148 /SigmaFactorBS="tactctgacaaaatgattaaaaacaaaatctcatGGTTTGtc caccccatgtccgtGAATACAATAAGAAATAAAgtatttctcgggaaagcgcaggatt c" /listShort="S624, spoVK" /listLong="ynbA, ynbB" /label="upshifts" CDS 1708451..1709419 /gene="spoVK" /locus_tag="BSU_17420" /old_locus_tag="BSU17420" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8464402, 22882546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8464402, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="mother cell sporulation ATPase" /protein_id="NP_389624.2" /db_xref="EnsemblGenomes-Gn:BSU17420" /db_xref="EnsemblGenomes-Tr:CAB13626" /db_xref="GOA:P27643" /db_xref="InterPro:IPR000641" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR014232" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11039" /db_xref="UniProtKB/Swiss-Prot:P27643" /translation="MLERAVTYKNNGQINIILNGQKQVLTNAEAEAEYQAALQKNEAK HGILKEIEKEMSALVGMEEMKRNIKEIYAWIFVNQKRAEQGLKVGKQALHMMFKGNPG TGKTTVARLIGKLFFEMNVLSKGHLIEAERADLVGEYIGHTAQKTRDLIKKSLGGILF IDEAYSLARGGEKDFGKEAIDTLVKHMEDKQHEFILILAGYSREMDHFLSLNPGLQSR FPISIDFPDYSVTQLMEIAKRMIDEREYQLSQEAEWKLKDYLMTVKSTTSPIKFSNGR FVRNVIEKSIRAQAMRLLMGDQYLKSDLMTIKSQDLSIKEEASGSA*" /label="spoVK CDS" gene 1708451..1709419 /gene="spoVK" /locus_tag="BSU_17420" /old_locus_tag="BSU17420" /label="spoVK gene" downshifts 1709388 /Source="Nicolas_upshifts" /id="D943" /incds=0 /nref=5 /ntot=41 /MaxReadThrough="2.7881" /MaxDrop="5.20495" /score="22.9164064" /energy="-15.5" /TU="U1392" /idTUdmin="U1392" /TUdmin="-109" /isTUend="FALSE" /label="downshifts" promotor_-35 1709483..1709491 /Source="Nicolas_upshift_promotors" /id="U1393" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.879120879120879" /psig=1 /xcortree=1849 /SigmaFactorBS="ggtctgttttttgctcgtatttccgcttttcaaagcaatcga tttGTGGTATACacatgcagggTTTGGTATGATAATACTACTgcccaatatgcaaaag a" /listShort="ynbA, ynbB, glnR, glnA" /listLong="S625, ynxB, S626, ynzF, ynzG, S627, ynaB, ynaC" /label="promotor_-35" upshifts 1709498 /Source="Nicolas_upshifts" /id="U1393" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.879120879120879" /psig=1 /xcortree=1849 /SigmaFactorBS="ggtctgttttttgctcgtatttccgcttttcaaagcaatcga tttGTGGTATACacatgcagggTTTGGTATGATAATACTACTgcccaatatgcaaaag a" /listShort="ynbA, ynbB, glnR, glnA" /listLong="S625, ynxB, S626, ynzF, ynzG, S627, ynaB, ynaC" /label="upshifts" promotor_-10 1709502..1709521 /Source="Nicolas_upshift_promotors" /id="U1393" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.879120879120879" /psig=1 /xcortree=1849 /SigmaFactorBS="ggtctgttttttgctcgtatttccgcttttcaaagcaatcga tttGTGGTATACacatgcagggTTTGGTATGATAATACTACTgcccaatatgcaaaag a" /listShort="ynbA, ynbB, glnR, glnA" /listLong="S625, ynxB, S626, ynzF, ynzG, S627, ynaB, ynaC" /label="promotor_-10" CDS 1709552..1710814 /gene="hflX" /locus_tag="BSU_17430" /old_locus_tag="BSU17430" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 19824612, 26458047, 26733579, 26951678, 27398305; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosome-splitting GTPase (also ATPase, rescuingstalled ribosomes, E-site binding)" /protein_id="NP_389625.2" /db_xref="EnsemblGenomes-Gn:BSU17430" /db_xref="EnsemblGenomes-Tr:CAB13627" /db_xref="GOA:P94478" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR016496" /db_xref="InterPro:IPR025121" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030394" /db_xref="InterPro:IPR032305" /db_xref="SubtiList:BG12263" /db_xref="UniProtKB/Swiss-Prot:P94478" /translation="MNEQETIQEKAILVGCQLPHITDEHFENSMEELASLTKTADGKV LTSVTQKRNRADAATYIGKGKVEELKALVEELEADLLIFNDELSPSQLKSLATAIEVK MIDRTQLILDIFAKRARTREGKLQIELAQLQYALPRLTGQGINLSRQGGGIGARGPGE TKLETDRRHIRNRIHEINTQLSTVIRHRSRYRERRKKNGVLQIALVGYTNAGKSTWFN RLTSADSYEEDLLFATLDPMTRKMVLPSGYSVLLSDTVGFIQDLPTTLIAAFRSTLEE VKEADLILHLIDSSNEDYAGHEKTVLRLLEELEADDIPMLTAYNKRDQKLPDFIPTAG RDHIMVSAKFEDDAAAFKEAIQRYLRQELLTSFEAHVPASEGKLLSRIKSETMVDRFY FNEENEQYDISGYVQEEQSIIGELKKYM*" /label="hflX CDS" gene 1709552..1710814 /gene="hflX" /locus_tag="BSU_17430" /old_locus_tag="BSU17430" /label="hflX gene" CDS 1710832..1712097 /gene="ynbB" /locus_tag="BSU_17440" /old_locus_tag="BSU17440" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191, 24610841; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative C-S lyase" /protein_id="NP_389626.2" /db_xref="EnsemblGenomes-Gn:BSU17440" /db_xref="EnsemblGenomes-Tr:CAB13628" /db_xref="GOA:P94479" /db_xref="InterPro:IPR000277" /db_xref="InterPro:IPR009651" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG12264" /db_xref="UniProtKB/Swiss-Prot:P94479" /translation="MFDTLTHGELLKKTAMEVEADIAGIHKQIEEISERNEWRVLQSY RKHKVSDTHFTPSTGYGYDDIGRDTLESIYADVFGGEAGLVRPQIISGTHAISIALFG VLRPGDELLYITGKPYDTLEEIVGVRGGENAGSLKDFQIGYNAVDLTKDGKIDYDAVA AAINPKTKVIGIQRSKGYANRPSFLISEIKEMIRFVKEINENLIVFVDNCYGEFVEEL EPCHVGADLMAGSLIKNPGGGLAKTGGYLVGKAKWIEACSYRMTSPGIGREAGASLYS LQEMYQGFFLAPHVVSQSLKGAVFTARFLEKLGFTSNPKWDAKRTDLIQSVEFSDREK MIAFCQAIQFASPINAHVTPYPAYMPGYEDDVIMAAGTFIQGASIELSADGPIRPPYV AYVQGGLTYSHVKNAICSAVDSLMQKQLI*" /label="ynbB CDS" gene 1710832..1712097 /gene="ynbB" /locus_tag="BSU_17440" /old_locus_tag="BSU17440" /label="ynbB gene" promotor_-35 1712145..1712152 /Source="Nicolas_upshift_promotors" /id="U1394" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2196 /SigmaFactorBS="atttgatgttaagaatccttacatcgTATTGACAcataatat aacatcACCTATAATGAAACTAAGTTaagaaaaggaggaaattgagatgagtgataat a" /listShort="glnR, glnA, S625, ynxB, S626, ynzF, ynzG" /listLong="S627, ynaB, ynaC" /label="promotor_-35" promotor_-10 1712167..1712186 /Source="Nicolas_upshift_promotors" /id="U1394" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2196 /SigmaFactorBS="atttgatgttaagaatccttacatcgTATTGACAcataatat aacatcACCTATAATGAAACTAAGTTaagaaaaggaggaaattgagatgagtgataat a" /listShort="glnR, glnA, S625, ynxB, S626, ynzF, ynzG" /listLong="S627, ynaB, ynaC" /label="promotor_-10" upshifts 1712179 /Source="Nicolas_upshifts" /id="U1394" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2196 /SigmaFactorBS="atttgatgttaagaatccttacatcgTATTGACAcataatat aacatcACCTATAATGAAACTAAGTTaagaaaaggaggaaattgagatgagtgataat a" /listShort="glnR, glnA, S625, ynxB, S626, ynzF, ynzG" /listLong="S627, ynaB, ynaC" /label="upshifts" CDS 1712207..1712614 /gene="glnR" /locus_tag="BSU_17450" /old_locus_tag="BSU17450" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9287005, 12374841, 16547045, 16885465, 22625175, 22720735, 25691471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9287005, 12374841, 16547045, 16885465, 22625175, 22720735, 25691471; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (nitrogen metabolism)" /protein_id="NP_389627.1" /db_xref="EnsemblGenomes-Gn:BSU17450" /db_xref="EnsemblGenomes-Tr:CAB13629" /db_xref="GOA:P37582" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="PDB:4R4E" /db_xref="SubtiList:BG10424" /db_xref="UniProtKB/Swiss-Prot:P37582" /translation="MSDNIRRSMPLFPIGIVMQLTELSARQIRYYEENGLIFPARSEG NRRLFSFHDVDKLLEIKHLIEQGVNMAGIKQILAKAEAEPEQKQNEKTKKPMKHDLSD DELRQLLKNELMQAGRFQRGNTFRQGDMSRFFH*" /label="glnR CDS" gene 1712207..1712614 /gene="glnR" /locus_tag="BSU_17450" /old_locus_tag="BSU17450" /label="glnR gene" downshifts complement(1712213) /Source="Nicolas_upshifts" /id="D944" /incds=0 /nref=2 /ntot=82 /MaxReadThrough="1.78139" /MaxDrop="3.45896" /score="-7.83781174" /energy="-10.3" /TU="NA" /idTUdmin="U1398" /TUdmin=3816 /isTUend="FALSE" /label="downshifts" misc_feature 1712595..1712613 /Source="Nicolas_upshift_promotors" /id="U1395" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.777222777222777" /psig="0.777222777222777" /xcortree=2197 /SigmaFactorBS="ttttcaaagagggaatacattccgtcaaggcgacaTGTCCCG CTTCTTTCATTAatccgttagcaactgttttgctatatacatttaccttttaagagga g" /listShort="glnA, S625, ynxB, S626" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1712620 /Source="Nicolas_upshifts" /id="U1395" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.777222777222777" /psig="0.777222777222777" /xcortree=2197 /SigmaFactorBS="ttttcaaagagggaatacattccgtcaaggcgacaTGTCCCG CTTCTTTCATTAatccgttagcaactgttttgctatatacatttaccttttaagagga g" /listShort="glnA, S625, ynxB, S626" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(1712673) /Source="Nicolas_upshifts" /id="D945" /incds=0 /nref=1 /ntot=72 /MaxReadThrough="1.70567" /MaxDrop="3.42395" /score="-7.83781174" /energy="-10.3" /TU="NA" /idTUdmin="U1398" /TUdmin=3356 /isTUend="FALSE" /label="downshifts" CDS 1712673..1714007 /gene="glnA" /locus_tag="BSU_17460" /old_locus_tag="BSU17460" /EC_number="6.3.1.2" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:13737, 11719184, 12142436, 16055443, 16885465, 19233925, 19251843" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 13737, 11719184, 12142436, 16055443, 16885465, 19233925, 19251843; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamine synthetase" /protein_id="NP_389628.1" /db_xref="EnsemblGenomes-Gn:BSU17460" /db_xref="EnsemblGenomes-Tr:CAB13630" /db_xref="GOA:P12425" /db_xref="InterPro:IPR001637" /db_xref="InterPro:IPR004809" /db_xref="InterPro:IPR008146" /db_xref="InterPro:IPR008147" /db_xref="InterPro:IPR014746" /db_xref="InterPro:IPR027302" /db_xref="InterPro:IPR027303" /db_xref="InterPro:IPR036651" /db_xref="PDB:2FWX" /db_xref="PDB:4LNF" /db_xref="PDB:4LNI" /db_xref="PDB:4LNK" /db_xref="PDB:4LNN" /db_xref="PDB:4LNO" /db_xref="PDB:4S0R" /db_xref="SubtiList:BG10425" /db_xref="UniProtKB/Swiss-Prot:P12425" /translation="MAKYTREDIEKLVKEENVKYIRLQFTDILGTIKNVEIPVSQLGK ALDNKVMFDGSSIEGFVRIEESDMYLYPDLNTFVIFPWTAEKGKVARFICDIYNPDGT PFEGDPRNNLKRILKEMEDLGFSDFNLGPEPEFFLFKLDEKGEPTLELNDKGGYFDLA PTDLGENCRRDIVLELEEMGFEIEASHHEVAPGQHEIDFKYAGAVRSCDDIQTFKLVV KTIARKHGLHATFMPKPLFGVNGSGMHCNLSLFKNGVNAFFDENADLQLSETAKHFIA GIVKHATSFTAVTNPTVNSYKRLVPGYEAPCYVAWSAQNRSPLIRIPASRGISTRVEV RSVDPAANPYLALSVLLAAGLDGIKNKLEAPAPIDRNIYVMSKEERMENGIVDLPATL AEALEEFKSNEVMVKALGEHLFEHFIEAKEIEWDMFRTQVHPWEREQYMSQY*" /label="glnA CDS" gene 1712673..1714007 /gene="glnA" /locus_tag="BSU_17460" /old_locus_tag="BSU17460" /label="glnA gene" downshifts 1713984 /Source="Nicolas_upshifts" /id="D946" /incds=0 /nref=266 /ntot=287 /MaxReadThrough="5.53201" /MaxDrop="7.28613" /score="29.7599306" /energy="-16.4" /TU="U1394,U1395" /idTUdmin="U1393" /TUdmin=1 /isTUend="TRUE" /label="downshifts" S_feature 1714029..>1714078 /Source="Nicolas_S_feature" /locus_tag="new_1879781_1880041" /HighExp="Cold, BT, LBGtran, G135, G180, Etha, G150, LBGexp, Oxctl, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigL, SigA" /TUshortPSig="0.777, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S625" SCAR 1714078..1714079 /created_by="User" /note="deletion occured in betwen marked nucleotides" /modified_by="User" /label="IIG_Bs04" S_feature <1714079..1714831 /Source="Nicolas_S_feature" /locus_tag="new_1886528_1887351" /HighExp="Lbstat, M0t90, S8, C30, Pyr, Lbtran, M40t90, S1, M/G, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S631" promotor_-10 complement(1714171..1714189) /Source="Nicolas_upshift_promotors" /id="U1402" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1005 /SigmaFactorBS="gtcatgaattgaaagaacggaatggccagaatagtttatGTT ATAagtccaaccctacatACATATATCAATACAGGAAagataaataagaagcaaaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1714189) /Source="Nicolas_upshifts" /id="U1402" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1005 /SigmaFactorBS="gtcatgaattgaaagaacggaatggccagaatagtttatGTT ATAagtccaaccctacatACATATATCAATACAGGAAagataaataagaagcaaaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1714205..1714210) /Source="Nicolas_upshift_promotors" /id="U1402" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1005 /SigmaFactorBS="gtcatgaattgaaagaacggaatggccagaatagtttatGTT ATAagtccaaccctacatACATATATCAATACAGGAAagataaataagaagcaaaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1714832..1716223 /gene="xynP" /locus_tag="BSU_17570" /old_locus_tag="BSU17570" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16684115, 16850406, 17183216, 20406496; Product type t : transporter" /codon_start=1 /transl_table=11 /product="H+-xyloside symporter" /protein_id="NP_389639.2" /db_xref="EnsemblGenomes-Gn:BSU17570" /db_xref="EnsemblGenomes-Tr:CAB13641" /db_xref="GOA:P94488" /db_xref="InterPro:IPR001927" /db_xref="InterPro:IPR018043" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12262" /db_xref="UniProtKB/Swiss-Prot:P94488" /translation="MLSENVKKISMVEKVGYASGDFACNLIYATVSTYLLFFYTDVFG LSAAAAGTMFLVVRIIDALADPFIGTIVDRTNSRFGRFRPYLLFGAFPFVILAILCFT TPDFSDMGKLIYAYITYVGLSLTYTTINVPYGALTSAMTRNNQEVVSITSVRMLFANL GGLVVAFFVPLLAAYLSDTSGNESLGWQLTMGILGMIGGCLLIFCFKSTKERVTLQKS EEKIKFTDIFEQFRVNRPLVVLSIFFIIIFGVNSISNSVGIYYVTYNLEREDLVKWYG LIGSLPALVILPFIPRLHQFLGKKKLLNYALLLNIIGLLALLFVPPSNVYLILVCRLI AAAGSLTAGGYMWALIPETIEYGEYRTGKRMGGLIYAIIGFFFKFGMALGGVVPGLVL DKFGYVANQAQTPAALMGILITTTIIPVFLLVLALIDINFYNLDEKKYKNMVRELENR DKVYLDHIDDFKA*" /label="xynP CDS" gene 1714832..1716223 /gene="xynP" /locus_tag="BSU_17570" /old_locus_tag="BSU17570" /label="xynP gene" CDS 1716254..1717855 /gene="xynB" /locus_tag="BSU_17580" /old_locus_tag="BSU17580" /EC_number="3.2.1.37" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 2440680, 6413490, 7816035, 9286998, 9973552, 16684115, 28066362; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xylan beta-1,4-xylosidase" /protein_id="NP_389640.2" /db_xref="EnsemblGenomes-Gn:BSU17580" /db_xref="EnsemblGenomes-Tr:CAB13642" /db_xref="GOA:P94489" /db_xref="InterPro:IPR006710" /db_xref="InterPro:IPR013320" /db_xref="InterPro:IPR023296" /db_xref="PDB:1YIF" /db_xref="SubtiList:BG11987" /db_xref="UniProtKB/Swiss-Prot:P94489" /translation="MKITNPVLKGFNPDPSICRAGEDYYIAVSTFEWFPGVQIHHSKD LVNWHLVAHPLQRVSQLDMKGNPNSGGVWAPCLSYSDGKFWLIYTDVKVVDGAWKDCH NYLVTCETINGDWSEPIKLNSSGFDASLFHDTDGKKYLLNMLWDHRIDRHSFGGIVIQ EYSDKEQKLIGKPKVIFEGTDRKLTEAPHLYHIGNYYYLLTAEGGTRYEHAATIARSA NIEGPYEVHPDNPILTSWHDPGNPLQKCGHASIVQTHTDEWYLAHLTGRPIHPDDDSI FQQRGYCPLGRETAIQKLYWKDEWPYVVGGKEGSLEVDAPSIPETIFEATYPEVDEFE DSTLNINFQTLRIPFTNELGSLTQAPNHLRLFGHESLTSTFTQAFVARRWQSLHFEAE TAVEFYPENFQQAAGLVNYYNTENWTALQVTHDEELGRILELTICDNFSFSQPLNNKI VIPREVKYVYLRVNIEKDKYYYFYSFNKEDWHKIDIALESKKLSDDYIRGGGFFTGAF VGMQCQDTSGNHIPADFRYFRYKEK*" /label="xynB CDS" gene 1716254..1717855 /gene="xynB" /locus_tag="BSU_17580" /old_locus_tag="BSU17580" /label="xynB gene" S_feature complement(1716370..1716675) /Source="Nicolas_S_feature" /locus_tag="new_1888890_1889195_c" /HighExp="S8, S6, S7, BT, C30, S5, Pyr, S4, B36, BC" /AntisenseName="xynB" /AntisenseCor="6.2527836498644102E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.985" /TUlongSig="NA" /TUlongPSig="NA" /label="S632" promotor_-10 complement(1716670..1716689) /Source="Nicolas_upshift_promotors" /id="U1403" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1333 /SigmaFactorBS="tcctgtataacaattcctccaaatGAGTGCCGAtcaatacgg tgatCCCATAACATATTTAATAAAtacttttttccatccgtatcatggaacaaagaag c" /listShort="S632" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1716675) /Source="Nicolas_upshifts" /id="U1403" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1333 /SigmaFactorBS="tcctgtataacaattcctccaaatGAGTGCCGAtcaatacgg tgatCCCATAACATATTTAATAAAtacttttttccatccgtatcatggaacaaagaag c" /listShort="S632" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1716703..1716711) /Source="Nicolas_upshift_promotors" /id="U1403" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1333 /SigmaFactorBS="tcctgtataacaattcctccaaatGAGTGCCGAtcaatacgg tgatCCCATAACATATTTAATAAAtacttttttccatccgtatcatggaacaaagaag c" /listShort="S632" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1717853 /Source="Nicolas_upshifts" /id="D951" /incds=0 /nref=2 /ntot=53 /MaxReadThrough="1.32947" /MaxDrop="3.8449" /score="13.0570501" /energy="-10.2" /TU="NA" /idTUdmin="U1400" /TUdmin=3190 /isTUend="FALSE" /label="downshifts" CDS complement(1717992..1719146) /gene="xylR" /locus_tag="BSU_17590" /old_locus_tag="BSU17590" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1588910, 1719948, 2544559, 7559331; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator" /protein_id="NP_389641.3" /db_xref="EnsemblGenomes-Gn:BSU17590" /db_xref="EnsemblGenomes-Tr:CAB13643" /db_xref="GOA:P94490" /db_xref="InterPro:IPR000600" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11986" /db_xref="UniProtKB/Swiss-Prot:P94490" /translation="MDIADQTFVKKVNQKLLLKEILKNSPISRAKLSEMTGLNKSTVS SQVNTLMKESMVFEIGQGQSSGGRRPVMLVFNKKAGYSVGIDVGVDYINGILTDLEGT IVLDQYRHLESNSPEITKDILIDMIHHFITQMPQSPYGLIGIGICVPGLIDKDQKIVF TPNSNWRDIDLKSSIQEKYNVPVFIENEANAGAYGEKVFGAAKNHDNIIYVSISTGIG IGVIINNHLYRGVSGFSGEMGHMTIDFNGPKCSCGNRGCWELYASEKALLKSLQTKEK KLSYQDIINLAHLNDIGTLNALQNFGFYLGIGLTNILNTFNPQAVILRNSIIESHPMV LNSMRSEVSSRVYSQLGNSYELLPSSLGQNAPALGMSSIVIDHFLDMITM*" /label="xylR CDS" gene complement(1717992..1719146) /gene="xylR" /locus_tag="BSU_17590" /old_locus_tag="BSU17590" /label="xylR gene" downshifts complement(1717995) /Source="Nicolas_upshifts" /id="D952" /incds=0 /nref=9 /ntot=198 /MaxReadThrough="2.56326" /MaxDrop="4.09398" /score="19.297583" /energy="-7.4" /TU="NA" /idTUdmin="U1405" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1719045..1719223) /Source="Nicolas_S_feature" /locus_tag="new_1891565_1891743_c" /HighExp="dia15, Etha, dia5, dia0, Cold, LBGstat, Lbexp, M0t45, Diami, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S633" promotor_-35 1719191..1719197 /Source="Nicolas_upshift_promotors" /id="U1404" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.48951048951049" /psig="0.487512487512487" /xcortree=661 /SigmaFactorBS="ccatttgtttaatctttaaattaagtatcaacatAGTACATa gcgaatctTCCCTTTATTATATCTAatgtgttcataaaaaactaaaaaaaatattgaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1719206..1719225) /Source="Nicolas_upshift_promotors" /id="U1405" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=1893 /SigmaFactorBS="ttcatcttatataacctcgtcagtattttcaatattttttTT AGttttttatgaacacATTAGATATAATAAAGGGAAgattcgctatgtactatgttga t" /listShort="S633, xylR" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 1719207..1719223 /Source="Nicolas_upshift_promotors" /id="U1404" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.48951048951049" /psig="0.487512487512487" /xcortree=661 /SigmaFactorBS="ccatttgtttaatctttaaattaagtatcaacatAGTACATa gcgaatctTCCCTTTATTATATCTAatgtgttcataaaaaactaaaaaaaatattgaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1719217 /Source="Nicolas_upshifts" /id="U1404" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.48951048951049" /psig="0.487512487512487" /xcortree=661 /SigmaFactorBS="ccatttgtttaatctttaaattaagtatcaacatAGTACATa gcgaatctTCCCTTTATTATATCTAatgtgttcataaaaaactaaaaaaaatattgaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1719223) /Source="Nicolas_upshifts" /id="U1405" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=1893 /SigmaFactorBS="ttcatcttatataacctcgtcagtattttcaatattttttTT AGttttttatgaacacATTAGATATAATAAAGGGAAgattcgctatgtactatgttga t" /listShort="S633, xylR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1719240..1719243) /Source="Nicolas_upshift_promotors" /id="U1405" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=1893 /SigmaFactorBS="ttcatcttatataacctcgtcagtattttcaatattttttTT AGttttttatgaacacATTAGATATAATAAAGGGAAgattcgctatgtactatgttga t" /listShort="S633, xylR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1719250..1719257 /Source="Nicolas_upshift_promotors" /id="U1406" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=1568 /SigmaFactorBS="atgtgttcataaaaaactaaaaaaaaTATTGAAAatactgac gaggttATATAAGATGAAAATAAGTTagtttgtttaaacaacaaactaataggtgatg t" /listShort="S634, xylA, S635, xylB, S636" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1719272..1719291 /Source="Nicolas_upshift_promotors" /id="U1406" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=1568 /SigmaFactorBS="atgtgttcataaaaaactaaaaaaaaTATTGAAAatactgac gaggttATATAAGATGAAAATAAGTTagtttgtttaaacaacaaactaataggtgatg t" /listShort="S634, xylA, S635, xylB, S636" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1719283..1719387 /Source="Nicolas_S_feature" /locus_tag="new_1891803_1891907" /HighExp="dia15, dia0, Lbexp, dia5, B60, Sw, G150, LPhT, Mt0, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S634" upshifts 1719284 /Source="Nicolas_upshifts" /id="U1406" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=1568 /SigmaFactorBS="atgtgttcataaaaaactaaaaaaaaTATTGAAAatactgac gaggttATATAAGATGAAAATAAGTTagtttgtttaaacaacaaactaataggtgatg t" /listShort="S634, xylA, S635, xylB, S636" /GFF_Attribute="listLong" /label="upshifts" CDS 1719388..1720725 /gene="xylA" /locus_tag="BSU_17600" /old_locus_tag="BSU17600" /EC_number="5.3.1.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7663444, 8132469" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7663444, 8132469; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xylose isomerase" /protein_id="NP_389642.2" /db_xref="EnsemblGenomes-Gn:BSU17600" /db_xref="EnsemblGenomes-Tr:CAB13644" /db_xref="GOA:P0CI80" /db_xref="InterPro:IPR001998" /db_xref="InterPro:IPR013022" /db_xref="InterPro:IPR013452" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG10806" /db_xref="UniProtKB/Swiss-Prot:P0CI80" /translation="MAQSHSSSINYFGSANKVVYEGKDSTNPLAFKYYNPQEVIGGKT LKEHLRFSIAYWHTFTADGTDVFGAATMQRPWDHYKGMDLAKMRVEAAFEMFEKLDAP FFAFHDRDIAPEGSTLKETNQNLDMIMGMIKDYMRNSGVKLLWNTANMFTNPRFVHGA ATSCNADVFAYAAAQVKKGLETAKELGAENYVFWGGREGYETLLNTDLKFELDNLARF MHMAVDYAKEIGYTGQFLIEPKPKEPTTHQYDTDAATTIAFLKQYGLDNHFKLNLEAN HATLAGHTFEHELRMARVHGLLGSVDANQGHPLLGWDTDEFPTDLYSTTLAMYEILQN GGLGSGGLNFDAKVRRSSFEPDDLIYAHIAGMDAFARGLKVAHKLIEDRVFEDVIQHR YRSFTEGIGLEIIEGRANFHTLEQYALNHKSIKNESGRQEKLKAILNQYILEV*" /label="xylA CDS" gene 1719388..1720725 /gene="xylA" /locus_tag="BSU_17600" /old_locus_tag="BSU17600" /label="xylA gene" S_feature 1720726..1720800 /Source="Nicolas_S_feature" /locus_tag="new_1893246_1893320" /HighExp="dia0, dia15, Sw, Lbexp, dia5, B60, Mt0, M0t45, G150, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S635" downshifts 1720757 /Source="Nicolas_upshifts" /id="D953" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="4.89699" /MaxDrop="3.40404" /score="13.0570501" /energy="-10.2" /TU="U1406" /idTUdmin="U1406" /TUdmin="-1892" /isTUend="FALSE" /label="downshifts" CDS 1720876..1722375 /gene="xylB" /locus_tag="BSU_17610" /old_locus_tag="BSU17610" /EC_number="2.7.1.17" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1660563, 8866023, 27467131; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xylulose kinase" /protein_id="NP_389643.1" /db_xref="EnsemblGenomes-Gn:BSU17610" /db_xref="EnsemblGenomes-Tr:CAB13645" /db_xref="GOA:P39211" /db_xref="InterPro:IPR000577" /db_xref="InterPro:IPR006000" /db_xref="InterPro:IPR018483" /db_xref="InterPro:IPR018484" /db_xref="InterPro:IPR018485" /db_xref="SubtiList:BG10807" /db_xref="UniProtKB/Swiss-Prot:P39211" /translation="MKYVIGIDLGTSAVKTILVNQNGKVCAETSKRYPLIQEKAGYSE QNPEDWVQQTIEALAELVSISNVQAKDIDGISYSGQMHGLVLLDQDRQVLRNAILWND TRTTPQCIRMTEKFGDHLLDITKNRVLEGFTLPKMLWVKEHEPELFKKTAVFLLPKDY VRFRMTGVIHTEYSDAAGTLLLHITRKEWSNDICNQIGISADICPPLVESHDCVGSLL PHVAAKTGLLEKTKVYAGGADNACGAIGAGILSSGKTLCSIGTSGVILSYEEEKERDF KGKVHFFNHGKKDSFYTMGVTLAAGYSLDWFKRTFAPNESFEQLLQGVEAIPIGANGL LYTPYLVGERTPHADSSIRGSLIGMDGAHNRKHFLRAIMEGITFSLHESIELFREAGK SVHTVVSIGGGAKNDTWLQMQADIFNTRVIKLENEQGPAMGAAMLAAFGSGWFESLEE CAEQFIREAAAFYPKAQNVQKYKTLFDLYKNIYTHTKDLNTALKSFRKN*" /label="xylB CDS" gene 1720876..1722375 /gene="xylB" /locus_tag="BSU_17610" /old_locus_tag="BSU17610" /label="xylB gene" S_feature 1722376..1722691 /Source="Nicolas_S_feature" /locus_tag="new_1894896_1895211" /HighExp="dia0, dia15, Lbexp, dia5, Mt0, M0t45, G150, Etha, Diami, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.51323200000000002" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S636" downshifts 1722649 /Source="Nicolas_upshifts" /id="D954" /incds=0 /nref=60 /ntot=197 /MaxReadThrough="0.61776" /MaxDrop="5.13425" /score="13.0570501" /energy="-10.2" /TU="NA" /idTUdmin="U1406" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1722858..1723493) /gene="yncB" /locus_tag="BSU_17620" /old_locus_tag="BSU17620" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11584000" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11584000; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA nuclease, lipoprotein (phage origin)" /protein_id="NP_389644.1" /db_xref="EnsemblGenomes-Gn:BSU17620" /db_xref="EnsemblGenomes-Tr:CAB13646" /db_xref="GOA:P94492" /db_xref="InterPro:IPR002071" /db_xref="InterPro:IPR016071" /db_xref="InterPro:IPR035437" /db_xref="SubtiList:BG12265" /db_xref="UniProtKB/Swiss-Prot:P94492" /translation="MKKILISMIAIVLSITLAACGSNHAAKNHSDSNGTEQVSQDTHS NEYNQTEQKAGTPHSKNQKKLVNVTLDRAIDGDTIKVIYNGKKDTVRYLLVDTPETKK PNSCVQPYGEDASKRNKELVNSGKLQLEFDKGDRRDKYGRLLAYVYVDGKSVQETLLK EGLARVAYVYEPNTKYIDQFRLDEQEAKSDKLSIWSKSGYVTNRGFNGCVK*" /label="yncB CDS" gene complement(1722858..1723493) /gene="yncB" /locus_tag="BSU_17620" /old_locus_tag="BSU17620" /label="yncB gene" promotor_-10 complement(1723530..1723549) /Source="Nicolas_upshift_promotors" /id="U1407" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.999000999001" /xcortree=2438 /SigmaFactorBS="gagtgttataagttcccttgaagttttcCATTCACAaaaaat gtccatatCGTTATAATGATGATGTTTAatcgcgaaaagagaaaatgataaagaggga a" /listShort="yncB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1723539) /Source="Nicolas_upshifts" /id="U1407" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.999000999001" /xcortree=2438 /SigmaFactorBS="gagtgttataagttcccttgaagttttcCATTCACAaaaaat gtccatatCGTTATAATGATGATGTTTAatcgcgaaaagagaaaatgataaagaggga a" /listShort="yncB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1723564..1723571) /Source="Nicolas_upshift_promotors" /id="U1407" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.999000999001" /xcortree=2438 /SigmaFactorBS="gagtgttataagttcccttgaagttttcCATTCACAaaaaat gtccatatCGTTATAATGATGATGTTTAatcgcgaaaagagaaaatgataaagaggga a" /listShort="yncB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1723681..1723688 /Source="Nicolas_upshift_promotors" /id="U1408" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=321 /SigmaFactorBS="ccatcacatagcggaaataaataatcctgaaaataaTATTGA CTgaaaatgcttttagAATTATGATAATATGAGAAAtgacaataatgtgacaaagaca t" /listShort="S637, yncC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1723703..1723722 /Source="Nicolas_upshift_promotors" /id="U1408" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=321 /SigmaFactorBS="ccatcacatagcggaaataaataatcctgaaaataaTATTGA CTgaaaatgcttttagAATTATGATAATATGAGAAAtgacaataatgtgacaaagaca t" /listShort="S637, yncC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1723705..1723903 /Source="Nicolas_S_feature" /locus_tag="new_1896225_1896423" /HighExp="T0.30H, Lbtran, T1.0H, M9-stat, M0t90, T1.30H, M40t90, T2.0H, T0.0H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S637" upshifts 1723705 /Source="Nicolas_upshifts" /id="U1408" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=321 /SigmaFactorBS="ccatcacatagcggaaataaataatcctgaaaataaTATTGA CTgaaaatgcttttagAATTATGATAATATGAGAAAtgacaataatgtgacaaagaca t" /listShort="S637, yncC" /GFF_Attribute="listLong" /label="upshifts" CDS 1723904..1725319 /gene="yncC" /locus_tag="BSU_17630" /old_locus_tag="BSU17630" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22900538, 23569278; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sugar transporter" /protein_id="NP_389645.2" /db_xref="EnsemblGenomes-Gn:BSU17630" /db_xref="EnsemblGenomes-Tr:CAB13647" /db_xref="GOA:P94493" /db_xref="InterPro:IPR003663" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12266" /db_xref="UniProtKB/Swiss-Prot:P94493" /translation="MDMNEHRNRRLKLIMISATFGGLLFGYDTGVINGALPFMARPDQ LDLTPVTEGLVTSILLLGAAFGALLCGRLADRYGRRKMILNLSFLFFLASLGTALAPN VFIMAVFRFLLGLAVGGASAMVPAFLAEMAPHEKRGRMVTQNELMIVGGQFLAYVFNA ILGVTMANTGHVWRYMLVICAVPAIMLFASMLKVPESPRWLISKGKNSEALRVLKQIR EDKRAEAECREIQEAVEKDTALEKASLKDFSTPWLRRLLWIGIGVAIVNQITGVNSIM YYGTQILKESGFGTKAALIANIGNGLISVIAVIFGIWLVGKVRRRPILLIGLAGTTTA LLLIAIFSIVLDGSMALPYVVLSLTVLFLAFMQGCVGPVTWLVIAEIFPQRLRGLGSG ISVFFLWILNFVIGFAFPILLSSVGLSFTFFIFVALGVLAIGFVYKFMPETKGRTLEE LEEHFRSRHDHNTPEQSVIEV*" /label="yncC CDS" gene 1723904..1725319 /gene="yncC" /locus_tag="BSU_17630" /old_locus_tag="BSU17630" /label="yncC gene" downshifts 1725309 /Source="Nicolas_upshifts" /id="D955" /incds=0 /nref=13 /ntot=69 /MaxReadThrough="0.90595" /MaxDrop="4.35189" /score="15.579587" /energy="-8.6" /TU="NA" /idTUdmin="U1408" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" downshifts complement(1725412) /Source="Nicolas_upshifts" /id="D956" /incds=0 /nref=13 /ntot=41 /MaxReadThrough="1.08869" /MaxDrop="5.39832" /score="24.3759796" /energy="-9.3" /TU="NA" /idTUdmin="U1409" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS complement(1725421..1726605) /gene="alrB" /locus_tag="BSU_17640" /old_locus_tag="BSU17640" /EC_number="5.1.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10348844, 18399999" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10348844, 18399999; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alanine racemase (minor activity)" /protein_id="NP_389646.1" /db_xref="EnsemblGenomes-Gn:BSU17640" /db_xref="EnsemblGenomes-Tr:CAB13648" /db_xref="GOA:P94494" /db_xref="InterPro:IPR000821" /db_xref="InterPro:IPR001608" /db_xref="InterPro:IPR009006" /db_xref="InterPro:IPR011079" /db_xref="InterPro:IPR020622" /db_xref="InterPro:IPR029066" /db_xref="PDB:5IRP" /db_xref="SubtiList:BG12267" /db_xref="UniProtKB/Swiss-Prot:P94494" /translation="MIKLCREVWIEVNLDAVKKNLRAIRRHIPHKSKIMAVVKANGYG HGSIEVARHALEHGASELAVASVEEGIVLRKAGITAPILVLGFTSLSCVKKSAAWNIT LSAFQVDWMKEANEILEKEASANRLAIHINVDTGMGRLGVRTKEELLEVVKALKASKF LRWTGIFTHFSTADEPDTTLTKLQHEKFISFLSFLKKQGIELPTVHMCNTAAAIAFPE FSADMIRLGIGLYGLYPSAYIKQLNLVKLEPALSLKARIAYVKTMRTEPRTVSYGATY IAEPNEVIATLPIGYADGYSRALSNRGFVLHRGKRVPVAGRVTMDMIMVSLGENGEGK QGDEVVIYGKQKGAEISVDEVAEMLNTINYEVVSTLSRRIPRFYIRDGEIFKVSTPVL YV*" /label="alrB CDS" gene complement(1725421..1726605) /gene="alrB" /locus_tag="BSU_17640" /old_locus_tag="BSU17640" /label="alrB gene" S_feature complement(1726606..1726685) /Source="Nicolas_S_feature" /locus_tag="new_1899126_1899205_c" /HighExp="S4, S5, S3, S6, S7, B36, BT, S8, LoTm, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.908" /TUlongSig="NA" /TUlongPSig="NA" /label="S638" promotor_-10 complement(1726678..1726696) /Source="Nicolas_upshift_promotors" /id="U1409" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.908091908091908" /psig="0.908091908091908" /xcortree=1129 /SigmaFactorBS="aggcaccttctcgtatcacatggatttgctgtTGAATGattt caaataaagttGAATAAAATAAGATCGAATcatccaacaattaacatttattcttgcg g" /listShort="S638, alrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1726689) /Source="Nicolas_upshifts" /id="U1409" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.908091908091908" /psig="0.908091908091908" /xcortree=1129 /SigmaFactorBS="aggcaccttctcgtatcacatggatttgctgtTGAATGattt caaataaagttGAATAAAATAAGATCGAATcatccaacaattaacatttattcttgcg g" /listShort="S638, alrB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1726712..1726717) /Source="Nicolas_upshift_promotors" /id="U1409" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.908091908091908" /psig="0.908091908091908" /xcortree=1129 /SigmaFactorBS="aggcaccttctcgtatcacatggatttgctgtTGAATGattt caaataaagttGAATAAAATAAGATCGAATcatccaacaattaacatttattcttgcg g" /listShort="S638, alrB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1726997..1727004 /Source="Nicolas_upshift_promotors" /id="U1410" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.687312687312687" /psig="0.996003996003996" /xcortree=2322 /SigmaFactorBS="ataatcggttgaaaaggcagtcgattccttGTTCCATAaacc taacatcagaGTATATAATTATACTCGTATtcacaaaaatcgtttaagtaaggggtat a" /listShort="yncE, yncF, S640, ynzJ, S642, S643, thyA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1727019..1727038 /Source="Nicolas_upshift_promotors" /id="U1410" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.687312687312687" /psig="0.996003996003996" /xcortree=2322 /SigmaFactorBS="ataatcggttgaaaaggcagtcgattccttGTTCCATAaacc taacatcagaGTATATAATTATACTCGTATtcacaaaaatcgtttaagtaaggggtat a" /listShort="yncE, yncF, S640, ynzJ, S642, S643, thyA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1727027 /Source="Nicolas_upshifts" /id="U1410" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.687312687312687" /psig="0.996003996003996" /xcortree=2322 /SigmaFactorBS="ataatcggttgaaaaggcagtcgattccttGTTCCATAaacc taacatcagaGTATATAATTATACTCGTATtcacaaaaatcgtttaagtaaggggtat a" /listShort="yncE, yncF, S640, ynzJ, S642, S643, thyA" /GFF_Attribute="listLong" /label="upshifts" CDS 1727069..1727530 /gene="yncE" /locus_tag="BSU_17650" /old_locus_tag="BSU17650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative prophage protein" /protein_id="NP_389648.2" /db_xref="EnsemblGenomes-Gn:BSU17650" /db_xref="EnsemblGenomes-Tr:CAB13649" /db_xref="InterPro:IPR020216" /db_xref="SubtiList:BG12268" /db_xref="UniProtKB/Swiss-Prot:P94495" /translation="MNRGVSFQIPNEYGNFLWRILQPVEIANYRWQTSGESYFVVEGE LDDEELFHDYEIVEGAVFEQQLKTNQYYTIFVELKAFPYGKMVNQVNTYEEFADSDCE LVLLIADNSYVSIYCKNKNIIEKLYFNALQHDFEDVQFITDENDTRTSLTV*" /label="yncE CDS" gene 1727069..1727530 /gene="yncE" /locus_tag="BSU_17650" /old_locus_tag="BSU17650" /label="yncE gene" CDS 1727560..1727994 /gene="dutA" /locus_tag="BSU_17660" /old_locus_tag="BSU17660" /EC_number="3.6.1.23" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11375514, 15939294, 16908222, 17169987, 21358047, 23897460" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11375514, 15939294, 16908222, 17169987, 21358047, 23897460; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="deoxyuridine 5'-triphosphate pyrophosphatase (phage origin)" /protein_id="NP_389649.1" /db_xref="EnsemblGenomes-Gn:BSU17660" /db_xref="EnsemblGenomes-Tr:CAB13650" /db_xref="GOA:O31801" /db_xref="InterPro:IPR029054" /db_xref="InterPro:IPR033704" /db_xref="InterPro:IPR036157" /db_xref="PDB:2XCD" /db_xref="PDB:2XCE" /db_xref="PDB:4AOO" /db_xref="PDB:4AOZ" /db_xref="PDB:4APZ" /db_xref="PDB:4B0H" /db_xref="SubtiList:BG13437" /db_xref="UniProtKB/Swiss-Prot:O31801" /translation="MTMQIKIKYLDETQTRISKIEQGDWIDLRAAEDVTIKKDEFKLV PLGVAMELPEGYEAHVVPRSSTYKNFGVIQTNSMGVIDESYKGDNDFWFFPAYALRDT EIKKGDRICQFRIMKKMPAVELVEVEHLGNEDRGGLGSTGTK*" /label="dutA CDS" gene 1727560..1727994 /gene="dutA" /locus_tag="BSU_17660" /old_locus_tag="BSU17660" /label="dutA gene" S_feature complement(1727743..1728048) /Source="Nicolas_S_feature" /locus_tag="new_1900263_1900568_c" /HighExp="LoTm, S5, T5.0H, S8, T4.0H, S4, S7, T3.30H, Cold, T-4.40H" /AntisenseName="yncF" /AntisenseCor="-0.40042805081531202" /AntisenseRegPval="-11.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S639" downshifts 1727841 /Source="Nicolas_upshifts" /id="D957" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="4.18195" /MaxDrop="2.2821" /score="0.171090809" /energy="-9.3" /TU="U1410" /idTUdmin="U1408" /TUdmin=2530 /isTUend="FALSE" /label="downshifts" S_feature 1727995..1729091 /Source="Nicolas_S_feature" /locus_tag="new_1900515_1901611" /HighExp="S8, G150, G180, dia0, G135, UNK1, MG 15, Lbexp, Fru, S7" /AntisenseName="cotU" /AntisenseCor="-0.266961200384908" /AntisenseRegPval="-5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S640" S_feature complement(1728050..1728335) /Source="Nicolas_S_feature" /locus_tag="new_1900570_1900855_c" /HighExp="LoTm, dia5, dia15, T3.30H, T3.0H, T-4.40H, T4.0H, T5.0H, T-3.40H, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.25207000000000002" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S641" downshifts complement(1728093) /Source="Nicolas_upshifts" /id="D958" /incds=0 /nref=2 /ntot=95 /MaxReadThrough="4.29622" /MaxDrop="2.9464" /score="11.6697365" /energy="-9.7" /TU="U1411" /idTUdmin="U1411" /TUdmin="-308" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1728330..1728349) /Source="Nicolas_upshift_promotors" /id="U1411" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.96903096903097" /psig="0.997002997002997" /xcortree=3122 /SigmaFactorBS="tatttctttatagagatgcttgtttcatcGACAACtcaatcc taaaTGTGGTAAAATCGATAAAAAtgtaaaaactgtaaatataataaaaggagcatct t" /listShort="S641, S639" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1728335) /Source="Nicolas_upshifts" /id="U1411" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.96903096903097" /psig="0.997002997002997" /xcortree=3122 /SigmaFactorBS="tatttctttatagagatgcttgtttcatcGACAACtcaatcc taaaTGTGGTAAAATCGATAAAAAtgtaaaaactgtaaatataataaaaggagcatct t" /listShort="S641, S639" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1728361..1728366) /Source="Nicolas_upshift_promotors" /id="U1411" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.96903096903097" /psig="0.997002997002997" /xcortree=3122 /SigmaFactorBS="tatttctttatagagatgcttgtttcatcGACAACtcaatcc taaaTGTGGTAAAATCGATAAAAAtgtaaaaactgtaaatataataaaaggagcatct t" /listShort="S641, S639" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1728597) /Source="Nicolas_upshifts" /id="D959" /incds=0 /nref=17 /ntot=130 /MaxReadThrough="2.07509" /MaxDrop="8.56023" /score="11.6697365" /energy="-9.7" /TU="NA" /idTUdmin="U1412" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(1728597..1728857) /gene="cotU" /locus_tag="BSU_17670" /old_locus_tag="BSU17670" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12562816, 18065538, 20023017" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562816, 18065538, 20023017; Product type f: factor" /codon_start=1 /transl_table=11 /product="spore coat protein" /protein_id="NP_389650.1" /db_xref="EnsemblGenomes-Gn:BSU17670" /db_xref="EnsemblGenomes-Tr:CAB13651" /db_xref="GOA:O31802" /db_xref="SubtiList:BG13471" /db_xref="UniProtKB/Swiss-Prot:O31802" /translation="MGYYKKYKEEYYTWKKTYYKKYYDNDKKHYDCDKYYDHDKKHYD YDKKYDDHDKKYYDDHDYHYEKKYYDDDDHYYDFVESYKKHH*" /label="cotU CDS" gene complement(1728597..1728857) /gene="cotU" /locus_tag="BSU_17670" /old_locus_tag="BSU17670" /label="cotU gene" promotor_-10 complement(1728878..1728897) /Source="Nicolas_upshift_promotors" /id="U1412" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1427 /SigmaFactorBS="agcctctttttactattcttatttcatttGACCATACCAtat catttaaacTTCATAAATTAAATTCGAATaacataaaggaggaatttaattgggttat t" /listShort="cotU" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1728888) /Source="Nicolas_upshifts" /id="U1412" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1427 /SigmaFactorBS="agcctctttttactattcttatttcatttGACCATACCAtat catttaaacTTCATAAATTAAATTCGAATaacataaaggaggaatttaattgggttat t" /listShort="cotU" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1728910..1728919) /Source="Nicolas_upshift_promotors" /id="U1412" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1427 /SigmaFactorBS="agcctctttttactattcttatttcatttGACCATACCAtat catttaaacTTCATAAATTAAATTCGAATaacataaaggaggaatttaattgggttat t" /listShort="cotU" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1729092..1729217 /gene="ynzJ" /locus_tag="BSU_17678" /old_locus_tag="BSU17678" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein (putative phage origin)" /db_xref="PSEUDO:CAX52624.1" /translation="MNVMVKIQELYDVIFHTAFEGFRVRHQKQTAKPARNRSYKE*" /label="ynzJ CDS" gene 1729092..1729217 /gene="ynzJ" /locus_tag="BSU_17678" /old_locus_tag="BSU17678" /pseudo /label="ynzJ gene" S_feature 1729218..1729334 /Source="Nicolas_S_feature" /locus_tag="new_1901738_1901854" /HighExp="G180, G135, G150, dia0, UNK1, S8, Lbexp, C90, MG 5, MG 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S642" CDS 1729261..1729425 /locus_tag="BSU_17679" /old_locus_tag="BSU17679" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein from phage origin" /protein_id="YP_009513957.1" /translation="MKLERIYFKESPIAHGQMTIDIEVKYNALNQKKLLEDLMCLDNF QFGIHKHLTI*" /label="conserved hypothetical protein from phage origin CDS" gene 1729261..1729425 /locus_tag="BSU_17679" /old_locus_tag="BSU17679" /label="gene" promotor_-35 1729309..1729318 /Source="Nicolas_upshift_promotors" /id="U1413" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.935064935064935" /psig="0.935064935064935" /xcortree=1261 /SigmaFactorBS="atttattttaaagaaagcccaattgcacatggaCAAATGACA AttgatattgaggtAAAATACAATGCATTAAATCagaaaaagctattggaggatttaa t" /listShort="S643, thyA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1729332..1729351 /Source="Nicolas_upshift_promotors" /id="U1413" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.935064935064935" /psig="0.935064935064935" /xcortree=1261 /SigmaFactorBS="atttattttaaagaaagcccaattgcacatggaCAAATGACA AttgatattgaggtAAAATACAATGCATTAAATCagaaaaagctattggaggatttaa t" /listShort="S643, thyA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1729336..1729646 /Source="Nicolas_S_feature" /locus_tag="new_1901856_1902166" /HighExp="S7, S6, S8, S5, BT, G/S, Pyr, G180, G150, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.585202" /TUshortSig="SigK, SigA" /TUshortPSig="0.935, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S643" upshifts 1729336 /Source="Nicolas_upshifts" /id="U1413" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.935064935064935" /psig="0.935064935064935" /xcortree=1261 /SigmaFactorBS="atttattttaaagaaagcccaattgcacatggaCAAATGACA AttgatattgaggtAAAATACAATGCATTAAATCagaaaaagctattggaggatttaa t" /listShort="S643, thyA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1729627..1729634 /Source="Nicolas_upshift_promotors" /id="U1414" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.916083916083916" /psig="0.99000999000999" /xcortree=1985 /SigmaFactorBS="gagtggaataagatcctcactttatctgcaagtgcttagTAT TTGCGataatattgcattCGTAATAAATTATGCTTAGCaactgaaaatgaaagaagga t" /listShort="thyA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1729648..1729667 /Source="Nicolas_upshift_promotors" /id="U1414" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.916083916083916" /psig="0.99000999000999" /xcortree=1985 /SigmaFactorBS="gagtggaataagatcctcactttatctgcaagtgcttagTAT TTGCGataatattgcattCGTAATAAATTATGCTTAGCaactgaaaatgaaagaagga t" /listShort="thyA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1729648 /Source="Nicolas_upshifts" /id="U1414" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.916083916083916" /psig="0.99000999000999" /xcortree=1985 /SigmaFactorBS="gagtggaataagatcctcactttatctgcaagtgcttagTAT TTGCGataatattgcattCGTAATAAATTATGCTTAGCaactgaaaatgaaagaagga t" /listShort="thyA" /GFF_Attribute="listLong" /label="upshifts" CDS 1729699..1730538 /gene="thyA" /locus_tag="BSU_17680" /old_locus_tag="BSU17680" /EC_number="2.1.1.45" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:416889, 418407, 9648749, 10091656, 10574451" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 416889, 418407, 9648749, 10091656, 10574451; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thymidylate synthase A (phage origin)" /protein_id="NP_389651.1" /db_xref="EnsemblGenomes-Gn:BSU17680" /db_xref="EnsemblGenomes-Tr:CAB13652" /db_xref="GOA:P0CI79" /db_xref="InterPro:IPR000398" /db_xref="InterPro:IPR020940" /db_xref="InterPro:IPR023451" /db_xref="InterPro:IPR036926" /db_xref="PDB:1B02" /db_xref="PDB:1BKO" /db_xref="PDB:1BKP" /db_xref="PDB:1BSF" /db_xref="PDB:1BSP" /db_xref="SubtiList:BG11190" /db_xref="UniProtKB/Swiss-Prot:P0CI79" /translation="MTQFDKQYNSIIKDIINNGISDEEFDVRTKWDSDGTPAHTLSVI SKQMRFDNSEVPILTTKKVAWKTAIKELLWIWQLKSNDVNDLNMMGVHIWDQWKQEDG TIGHAYGFQLGKKNRSLNGEKVDQVDYLLHQLKNNPSSRRHITMLWNPDELDAMALTP CVYETQWYVKHGKLHLEVRARSNDMALGNPFNVFQYNVLQRMIAQVTGYELGEYIFNI GDCHVYTRHIDNLKIQMEREQFEAPELWINPEVKDFYDFTIDDFKLINYKHGDKLLFE VAV*" /label="thyA CDS" gene 1729699..1730538 /gene="thyA" /locus_tag="BSU_17680" /old_locus_tag="BSU17680" /label="thyA gene" promotor_-10 complement(1729721..1729740) /Source="Nicolas_upshift_promotors" /id="U1415" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.651348651348651" /psig="0.982017982017982" /xcortree=3110 /SigmaFactorBS="ccatctgagtcccacttggttcttacatcaaactcttcgtct gaGATTccattattgataatATCCTTTATAATTGAATTGTattgtttatcgaattgcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1729742) /Source="Nicolas_upshifts" /id="U1415" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.651348651348651" /psig="0.982017982017982" /xcortree=3110 /SigmaFactorBS="ccatctgagtcccacttggttcttacatcaaactcttcgtct gaGATTccattattgataatATCCTTTATAATTGAATTGTattgtttatcgaattgcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1729755..1729758) /Source="Nicolas_upshift_promotors" /id="U1415" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.651348651348651" /psig="0.982017982017982" /xcortree=3110 /SigmaFactorBS="ccatctgagtcccacttggttcttacatcaaactcttcgtct gaGATTccattattgataatATCCTTTATAATTGAATTGTattgtttatcgaattgcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1730498 /Source="Nicolas_upshifts" /id="D960" /incds=0 /nref=6 /ntot=143 /MaxReadThrough="4.34299" /MaxDrop="3.3234" /score="1.39203037" /energy="-7.7" /TU="U1410,U1414" /idTUdmin="U1413" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" downshifts complement(1730644) /Source="Nicolas_upshifts" /id="D961" /incds=0 /nref=6 /ntot=150 /MaxReadThrough="3.28185" /MaxDrop="3.73135" /score="3.23768043" /energy="-6.6" /TU="U1417" /idTUdmin="U1417" /TUdmin="-286" /isTUend="FALSE" /label="downshifts" S_feature complement(1730645..1730951) /Source="Nicolas_S_feature" /locus_tag="new_1903165_1903471_c" /HighExp="LBGstat, Lbstat, LoTm, B60, LPhT, M9-stat, T1.30H, B36, nit, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99924299999999999" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S644" CDS complement(1730661..1730948) /locus_tag="BSU_17689" /old_locus_tag="BSU17689" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_009513958.1" /translation="MEHTGHSSFLQLFCLNLTLIRVEIGMKYEKTSLFGMILVIVALL ISIYFMCNTNALIPAGYDLAIHGIVISRTVMIAFTLYLVSKLGYFLLNKKD*" /label="conserved protein of unknown function CDS" gene complement(1730661..1730948) /locus_tag="BSU_17689" /old_locus_tag="BSU17689" /label="gene" downshifts complement(1730688) /Source="Nicolas_upshifts" /id="D962" /incds=0 /nref=2 /ntot=85 /MaxReadThrough="3.82042" /MaxDrop="6.47995" /score="3.23768043" /energy="-6.6" /TU="U1417" /idTUdmin="U1418" /TUdmin=308 /isTUend="FALSE" /label="downshifts" promotor_-35 1730775..1730783 /Source="Nicolas_upshift_promotors" /id="U1416" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=1393 /SigmaFactorBS="tattacaattccatgaatagctagatcatatccagcAGGTAT CAAcgcatttgtattaCACATAAAATATATAGATATtagaagtgctacaataactaaa a" /listShort="S645" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1730797..1730816 /Source="Nicolas_upshift_promotors" /id="U1416" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=1393 /SigmaFactorBS="tattacaattccatgaatagctagatcatatccagcAGGTAT CAAcgcatttgtattaCACATAAAATATATAGATATtagaagtgctacaataactaaa a" /listShort="S645" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1730799 /Source="Nicolas_upshifts" /id="U1416" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=1393 /SigmaFactorBS="tattacaattccatgaatagctagatcatatccagcAGGTAT CAAcgcatttgtattaCACATAAAATATATAGATATtagaagtgctacaataactaaa a" /listShort="S645" /GFF_Attribute="listLong" /label="upshifts" S_feature 1730810..1730970 /Source="Nicolas_S_feature" /locus_tag="new_1903330_1903490" /HighExp="S8, S6, S7, BT, S5, S4, S3, Pyr, G/S, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.98" /TUlongSig="NA" /TUlongPSig="NA" /label="S645" downshifts 1730942 /Source="Nicolas_upshifts" /id="D963" /incds=0 /nref=13 /ntot=53 /MaxReadThrough="1.26429" /MaxDrop="5.75919" /score="7.35184753" /energy="-11.1" /TU="NA" /idTUdmin="U1416" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1730991..1731713) /gene="yncM" /locus_tag="BSU_17690" /old_locus_tag="BSU17690" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences" /codon_start=1 /transl_table=11 /product="conserved exported protein" /protein_id="NP_389652.2" /db_xref="EnsemblGenomes-Gn:BSU17690" /db_xref="EnsemblGenomes-Tr:CAB13653" /db_xref="GOA:O31803" /db_xref="InterPro:IPR029143" /db_xref="PDB:4HFS" /db_xref="SubtiList:BG13438" /db_xref="UniProtKB/Swiss-Prot:O31803" /translation="MVKKVLIAGAVGTAVLFGTLSSGIPGLPAADAQVAKAASELPNG IGGRVYLNSTGAVFTAKIVLPETVKNNDSVSTPYIYSGFRATSGTEADIGLQYSKQYN VWKPLMKVGSKNEETYIEGKDKFTYNKGFRPGSTVQMTIYKNLSGNTRMTLWGTNNDG YTGRIITEIQGTNIGTISKWKTLATAAVSYESQRDAIKATFSTSFNNITIDNKAVTPV VDTQDFAKVSVAGNNVTISVNK*" /label="yncM CDS" gene complement(1730991..1731713) /gene="yncM" /locus_tag="BSU_17690" /old_locus_tag="BSU17690" /label="yncM gene" downshifts complement(1730996) /Source="Nicolas_upshifts" /id="D964" /incds=0 /nref=31 /ntot=133 /MaxReadThrough="5.62856" /MaxDrop="4.3658" /score="0.425084384" /energy="-11.1" /TU="U1417" /idTUdmin="U1418" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(1731738..1731757) /Source="Nicolas_upshift_promotors" /id="U1417" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.51048951048951" /psig="0.994005994005994" /xcortree=503 /SigmaFactorBS="ttcaaaatgaaatattttgtcgatttatatacgtaaatccag ttccaaaATAAGGTATAATAAATGGCGaaaccactatcaaaagggggaattttggtga a" /listShort="yncM, S644" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1731746) /Source="Nicolas_upshifts" /id="U1417" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.51048951048951" /psig="0.994005994005994" /xcortree=503 /SigmaFactorBS="ttcaaaatgaaatattttgtcgatttatatacgtaaatccag ttccaaaATAAGGTATAATAAATGGCGaaaccactatcaaaagggggaattttggtga a" /listShort="yncM, S644" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1731748..1731872) /Source="Nicolas_S_feature" /locus_tag="new_1904268_1904392_c" /HighExp="H2O2, dia15, S8, G180, G150, Paraq, Oxctl, LBGstat, G135, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S646" CDS complement(1731873..1732229) /gene="ynzK" /locus_tag="BSU_17699" /old_locus_tag="BSU17699" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein of unknown function (phage origin)" /protein_id="YP_003097731.1" /db_xref="EnsemblGenomes-Gn:BSU17699" /db_xref="EnsemblGenomes-Tr:CAX52625" /db_xref="GOA:C0H417" /db_xref="InterPro:IPR025621" /db_xref="UniProtKB/Swiss-Prot:C0H417" /translation="MYRNIVFYLILLCLFISVVMKSFEVIRTIANVICFIFVLLYFKD EMKTYSRKALAILSICFLFLVGICAFIILQGQTLMKRHLFFTGLETIAGILLIIVSLS ICTFILRKISNRLKRM*" /label="ynzK CDS" gene complement(1731873..1732229) /gene="ynzK" /locus_tag="BSU_17699" /old_locus_tag="BSU17699" /label="ynzK gene" promotor_-10 complement(1732253..1732272) /Source="Nicolas_upshift_promotors" /id="U1418" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=1838 /SigmaFactorBS="acatagtttagttagttcataagtgagcgcattcaattTATT GcagttacaaagaaacTTTTATAAACTCTTTGAGGAtcctacataaaaggagaggttt t" /listShort="ynzK, S646, yncM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1732270) /Source="Nicolas_upshifts" /id="U1418" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=1838 /SigmaFactorBS="acatagtttagttagttcataagtgagcgcattcaattTATT GcagttacaaagaaacTTTTATAAACTCTTTGAGGAtcctacataaaaggagaggttt t" /listShort="ynzK, S646, yncM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1732288..1732292) /Source="Nicolas_upshift_promotors" /id="U1418" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=1838 /SigmaFactorBS="acatagtttagttagttcataagtgagcgcattcaattTATT GcagttacaaagaaacTTTTATAAACTCTTTGAGGAtcctacataaaaggagaggttt t" /listShort="ynzK, S646, yncM" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1732469) /Source="Nicolas_upshifts" /id="D965" /incds=0 /nref=58 /ntot=194 /MaxReadThrough="0.902090000000001" /MaxDrop="9.00312" /score="34.0680178" /energy="-10.8" /TU="NA" /idTUdmin="U1419" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" CDS complement(1732475..1732675) /gene="cotC" /locus_tag="BSU_17700" /old_locus_tag="BSU17700" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10788508, 11741866, 14762008, 18065538, 2821284, 19933362, 20023017" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10788508, 11741866, 14762008, 18065538, 2821284, 19933362, 20023017; Product type s: structure" /codon_start=1 /transl_table=11 /product="spore coat protein (outer)" /protein_id="NP_389653.2" /db_xref="EnsemblGenomes-Gn:BSU17700" /db_xref="EnsemblGenomes-Tr:CAB13654" /db_xref="GOA:P07790" /db_xref="SubtiList:BG10492" /db_xref="UniProtKB/Swiss-Prot:P07790" /translation="MGYYKKYKEEYYTVKKTYYKKYYEYDKKDYDCDYDKKYDDYDKK YYDHDKKDYDYVVEYKKHKKHY*" /label="cotC CDS" gene complement(1732475..1732675) /gene="cotC" /locus_tag="BSU_17700" /old_locus_tag="BSU17700" /label="cotC gene" downshifts 1732658 /Source="Nicolas_upshifts" /id="D966" /incds=0 /nref=14 /ntot=29 /MaxReadThrough="1.37504" /MaxDrop="5.08099" /score="-4.2739983" /energy="-8" /TU="NA" /idTUdmin="U1416" /TUdmin=1716 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1732697..1732716) /Source="Nicolas_upshift_promotors" /id="U1419" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=1429 /SigmaFactorBS="acagcccttttttccttctatgattttaactGTCCAAGCCGc aaaatctactcGCCGTATAATAAAGCGTAGTaaaaataaaggaggagtatatatgggt t" /listShort="cotC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1732709) /Source="Nicolas_upshifts" /id="U1419" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=1429 /SigmaFactorBS="acagcccttttttccttctatgattttaactGTCCAAGCCGc aaaatctactcGCCGTATAATAAAGCGTAGTaaaaataaaggaggagtatatatgggt t" /listShort="cotC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1732729..1732738) /Source="Nicolas_upshift_promotors" /id="U1419" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=1429 /SigmaFactorBS="acagcccttttttccttctatgattttaactGTCCAAGCCGc aaaatctactcGCCGTATAATAAAGCGTAGTaaaaataaaggaggagtatatatgggt t" /listShort="cotC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1732850..1733038) /gene="tatAC" /locus_tag="BSU_17710" /old_locus_tag="BSU17710" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10974125, 11007775, 26239117" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10974125, 11007775, 26239117; Product type t: transporter" /codon_start=1 /transl_table=11 /product="component of the twin-arginine pre-protein translocation pathway" /protein_id="NP_389654.1" /db_xref="EnsemblGenomes-Gn:BSU17710" /db_xref="EnsemblGenomes-Tr:CAB13655" /db_xref="GOA:O31804" /db_xref="InterPro:IPR003369" /db_xref="InterPro:IPR006312" /db_xref="SubtiList:BG13464" /db_xref="UniProtKB/Swiss-Prot:O31804" /translation="MELSFTKILVILFVGFLVFGPDKLPALGRAAGKALSEFKQATSG LTQDIRKNDSENKEDKQM*" /label="tatAC CDS" gene complement(1732850..1733038) /gene="tatAC" /locus_tag="BSU_17710" /old_locus_tag="BSU17710" /label="tatAC gene" downshifts complement(1732866) /Source="Nicolas_upshifts" /id="D967" /incds=0 /nref=213 /ntot=254 /MaxReadThrough="3.38696" /MaxDrop="6.07983" /score="8.58114058" /energy="-11" /TU="U1420,U1421" /idTUdmin="U1420" /TUdmin="-374" /isTUend="FALSE" /label="downshifts" misc_feature complement(1733007..1733014) /Source="Nicolas_upshift_promotors" /id="U1420" /multdbtbs="-" /comp="M1" /sig="Sig-" /pcomp="0.405594405594406" /psig="0.405594405594406" /xcortree=1585 /SigmaFactorBS="aatttgtttaaaaggttgtacttcaatcagggggaaaaggat atggaattaagcttcacaaaaataCTCGTTATtttgtttgtgggttttttagtatttg g" /listShort="tatAC, cotC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1733020) /Source="Nicolas_upshifts" /id="U1420" /multdbtbs="-" /comp="M1" /sig="Sig-" /pcomp="0.405594405594406" /psig="0.405594405594406" /xcortree=1585 /SigmaFactorBS="aatttgtttaaaaggttgtacttcaatcagggggaaaaggat atggaattaagcttcacaaaaataCTCGTTATtttgtttgtgggttttttagtatttg g" /listShort="tatAC, cotC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1733067..1733086) /Source="Nicolas_upshift_promotors" /id="U1421" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=488 /SigmaFactorBS="cgtctttgtgctggttttaaaatgttcaaaataaatgCATTC CCAtttgtactgctatcTCTTATAATTTGTTTAAAAGgttgtacttcaatcaggggga a" /listShort="tatAC, cotC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1733085) /Source="Nicolas_upshifts" /id="U1421" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=488 /SigmaFactorBS="cgtctttgtgctggttttaaaatgttcaaaataaatgCATTC CCAtttgtactgctatcTCTTATAATTTGTTTAAAAGgttgtacttcaatcaggggga a" /listShort="tatAC, cotC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1733101..1733108) /Source="Nicolas_upshift_promotors" /id="U1421" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=488 /SigmaFactorBS="cgtctttgtgctggttttaaaatgttcaaaataaatgCATTC CCAtttgtactgctatcTCTTATAATTTGTTTAAAAGgttgtacttcaatcaggggga a" /listShort="tatAC, cotC" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1733117..1733254 /locus_tag="BSU_17715" /old_locus_tag="BSU17715" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513959.1" /translation="MNILKPAQRRIHKTAAAEYNVQCHLPKKQEAGWINYVALPEMIQ T*" /label="hypothetical protein CDS" gene 1733117..1733254 /locus_tag="BSU_17715" /old_locus_tag="BSU17715" /label="gene" promotor_-35 1733148..1733153 /Source="Nicolas_upshift_promotors" /id="U1422" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1117 /SigmaFactorBS="ttaaaaccagcacaaagacggaTTCATAaaacggctgctgct GAATATAATGTCCAATGCCacctgcctaagaagcaggaggcaggctggatcaattatg t" /listShort="S647, yndA, S648, ynzB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1733168..1733186 /Source="Nicolas_upshift_promotors" /id="U1422" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1117 /SigmaFactorBS="ttaaaaccagcacaaagacggaTTCATAaaacggctgctgct GAATATAATGTCCAATGCCacctgcctaagaagcaggaggcaggctggatcaattatg t" /listShort="S647, yndA, S648, ynzB" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1733186..1733288 /Source="Nicolas_S_feature" /locus_tag="new_1905706_1905808" /HighExp="S3, S4, LoTm, BT, B36, S5, S7, S6, T5.0H, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.35884500000000003" /TUshortSig="SigEF" /TUshortPSig="0.983" /TUlongSig="NA" /TUlongPSig="NA" /label="S647" upshifts 1733186 /Source="Nicolas_upshifts" /id="U1422" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1117 /SigmaFactorBS="ttaaaaccagcacaaagacggaTTCATAaaacggctgctgct GAATATAATGTCCAATGCCacctgcctaagaagcaggaggcaggctggatcaattatg t" /listShort="S647, yndA, S648, ynzB" /GFF_Attribute="listLong" /label="upshifts" CDS 1733289..1733687 /gene="yndA" /locus_tag="BSU_17720" /old_locus_tag="BSU17720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="putative exported protein of unknown function" /protein_id="NP_389655.1" /db_xref="EnsemblGenomes-Gn:BSU17720" /db_xref="EnsemblGenomes-Tr:CAB13656" /db_xref="SubtiList:BG13439" /db_xref="UniProtKB/Swiss-Prot:O31805" /translation="MRFTKVVGFLSVLGLAAVFPLTAQAEKAGTAGAGEWDKLGTYTY TYSSPTVYSTGGDFRVCLSGSTPFSVSLHLYEDDPGDNPDDYVGANYFSPGECHTFGS IGKFVDGSNNKAEFFVTDYSGKSKTVTFYD*" /label="yndA CDS" gene 1733289..1733687 /gene="yndA" /locus_tag="BSU_17720" /old_locus_tag="BSU17720" /label="yndA gene" S_feature 1733688..1734492 /Source="Nicolas_S_feature" /locus_tag="new_1906208_1907012" /HighExp="LoTm, S3, BT, S4, B36, S6, S5, S7, S8, T5.0H" /AntisenseName="yndB" /AntisenseCor="-0.559713635360228" /AntisenseRegPval="-22.9" /CDS_PredictionProba="0.91098199999999996" /TUshortSig="SigEF" /TUshortPSig="0.983" /TUlongSig="NA" /TUlongPSig="NA" /label="S648" CDS complement(1733752..1734186) /gene="flvS" /locus_tag="BSU_17730" /old_locus_tag="BSU17730" /experiment="publication(s) with functional evidences, PMID:20818668, 28160315" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20818668, 28160315; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of stress-related ATPase (flavonoid-sensing)" /protein_id="NP_389656.1" /db_xref="EnsemblGenomes-Gn:BSU17730" /db_xref="EnsemblGenomes-Tr:CAB13657" /db_xref="GOA:O31806" /db_xref="InterPro:IPR013538" /db_xref="InterPro:IPR023393" /db_xref="PDB:2KEW" /db_xref="PDB:2KTE" /db_xref="SubtiList:BG13440" /db_xref="UniProtKB/Swiss-Prot:O31806" /translation="MAQNNENALPDITKSITLEAPIQKVWETVSTSEGIAKWFMPNDF QLKEGQEFHLQSPFGPSPCKVLAVQAPTELSFEWDTEGWVVTFQLEDLGEKTGFTLIH SGWKEPNEVIGKANEKSSVVRGKMDGGWTGIVNERLRKAVEE*" /label="flvS CDS" gene complement(1733752..1734186) /gene="flvS" /locus_tag="BSU_17730" /old_locus_tag="BSU17730" /label="flvS gene" downshifts complement(1733768) /Source="Nicolas_upshifts" /id="D968" /incds=0 /nref=213 /ntot=253 /MaxReadThrough="1.7995" /MaxDrop="6.63594" /score="29.1580701" /energy="-7" /TU="NA" /idTUdmin="U1423" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1734216..1734235) /Source="Nicolas_upshift_promotors" /id="U1423" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.487512487512487" /psig="0.996003996003996" /xcortree=2282 /SigmaFactorBS="ctgttcaacagcagctctagcataaataatgcacgcTATGGA CAtgatcttattagtTATTATATGATTGAATTGAAaaaacatcatatgtcaagaggta a" /listShort="yndB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1734232) /Source="Nicolas_upshifts" /id="U1423" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.487512487512487" /psig="0.996003996003996" /xcortree=2282 /SigmaFactorBS="ctgttcaacagcagctctagcataaataatgcacgcTATGGA CAtgatcttattagtTATTATATGATTGAATTGAAaaaacatcatatgtcaagaggta a" /listShort="yndB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1734249..1734256) /Source="Nicolas_upshift_promotors" /id="U1423" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.487512487512487" /psig="0.996003996003996" /xcortree=2282 /SigmaFactorBS="ctgttcaacagcagctctagcataaataatgcacgcTATGGA CAtgatcttattagtTATTATATGATTGAATTGAAaaaacatcatatgtcaagaggta a" /listShort="yndB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1734493..1734681 /gene="ynzB" /locus_tag="BSU_17740" /old_locus_tag="BSU17740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23625846" /codon_start=1 /transl_table=11 /product="conserved protein involved in spore germination" /protein_id="NP_389657.2" /db_xref="EnsemblGenomes-Gn:BSU17740" /db_xref="EnsemblGenomes-Tr:CAB13658" /db_xref="SubtiList:BG13465" /db_xref="UniProtKB/Swiss-Prot:O31807" /translation="MLGKIKAAIDNSPGKPARILVSEKAFQQLEEEMRFVYVSKPKTI MGIPVEVSDQAESFKLEF*" /label="ynzB CDS" gene 1734493..1734681 /gene="ynzB" /locus_tag="BSU_17740" /old_locus_tag="BSU17740" /label="ynzB gene" S_feature 1734682..1734767 /Source="Nicolas_S_feature" /locus_tag="new_1907202_1907287" /HighExp="LoTm, BT, S4, S6, S3, S8, S7, B36, S5, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S649" downshifts 1734726 /Source="Nicolas_upshifts" /id="D969" /incds=0 /nref=7 /ntot=89 /MaxReadThrough="2.20002" /MaxDrop="4.21414" /score="19.5879917" /energy="-11.9" /TU="NA" /idTUdmin="U1422" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1734796..1734802 /Source="Nicolas_upshift_promotors" /id="U1424" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=875 /SigmaFactorBS="tgatgaaatgttcatcatgcttttttattgagaaaaaagacg AACATAAaaaataggtatacGGGAAAAATAATcctattagagagaggggaactgacag a" /listShort="S650, yndD" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1734814..1734973 /Source="Nicolas_S_feature" /locus_tag="new_1907334_1907493" /HighExp="S8, S4, S6, S7, S5, S3, BT, ferm, LoTm, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.95681300000000002" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S650" upshifts 1734814 /Source="Nicolas_upshifts" /id="U1424" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=875 /SigmaFactorBS="tgatgaaatgttcatcatgcttttttattgagaaaaaagacg AACATAAaaaataggtatacGGGAAAAATAATcctattagagagaggggaactgacag a" /listShort="S650, yndD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1734816..1734827 /Source="Nicolas_upshift_promotors" /id="U1424" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=875 /SigmaFactorBS="tgatgaaatgttcatcatgcttttttattgagaaaaaagacg AACATAAaaaataggtatacGGGAAAAATAATcctattagagagaggggaactgacag a" /listShort="S650, yndD" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1734974..1736536 /gene="yndD" /locus_tag="BSU_17750" /old_locus_tag="BSU17750" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 10762253, 27208128; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination receptor subunit" /protein_id="NP_389658.1" /db_xref="EnsemblGenomes-Gn:BSU17750" /db_xref="EnsemblGenomes-Tr:CAB13659" /db_xref="GOA:O31808" /db_xref="InterPro:IPR004995" /db_xref="SubtiList:BG13441" /db_xref="UniProtKB/Swiss-Prot:O31808" /translation="MMRWRNNQYKTQKQHKSDYSTAEKQDQDVLTGNIGYDLEHVKRK IGHNGDVHFRELEITQLHVKAALIFVEGLSDQDLINKGLSVLVMNQPNQVSDEISQSG KGILTSKQIKNQIVSIGDVIDSEKISDIVLNVFMGSTALLIDGIPQAFLLGTVKKQNR SIEEPLSEALVRGPRTGFTEELSTNTALLRQQGKNDQLTLQRFEVGTRLKKDLIIAYM NDIADPKVVEEVRKRVRGIEIDHLPESGYVEQLIEDNYLSPFPQVQSTERPDRVISGL MEGRVAILLDGTPFALIVPVTFSMMLQSPEDYYERWFPSSLIRLLRFIAAMITLFAPA LYISFISFHPGLIPTKLAISISGTRQGVPFPSLIEALFMEVAIEILREAGLRLPKPIG PAIGIVGGLIIGEAAVQAGIVSPIMVIVVALTAISSFAIPHYSTGIALRMLRFGAMFC AAVFGLFGVIMYYLLLSSHVVKLKSFGVPYASPAVPYHLKDWKDFVIRMPLLVMKRRP KMMNTDNTKRVK*" /label="yndD CDS" gene 1734974..1736536 /gene="yndD" /locus_tag="BSU_17750" /old_locus_tag="BSU17750" /label="yndD gene" promotor_-10 complement(1735277..1735296) /Source="Nicolas_upshift_promotors" /id="U1425" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.982017982017982" /xcortree=2029 /SigmaFactorBS="ctgaatctatgacatcaccgattgatacGATTTGATttttta tctgtttcGAAGTTAAAATACCTTTGCCggattgagaaatttcatcgcttacctgatt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1735286) /Source="Nicolas_upshifts" /id="U1425" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.982017982017982" /xcortree=2029 /SigmaFactorBS="ctgaatctatgacatcaccgattgatacGATTTGATttttta tctgtttcGAAGTTAAAATACCTTTGCCggattgagaaatttcatcgcttacctgatt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1735311..1735318) /Source="Nicolas_upshift_promotors" /id="U1425" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.982017982017982" /xcortree=2029 /SigmaFactorBS="ctgaatctatgacatcaccgattgatacGATTTGATttttta tctgtttcGAAGTTAAAATACCTTTGCCggattgagaaatttcatcgcttacctgatt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1736566..1737657 /gene="yndE" /locus_tag="BSU_17760" /old_locus_tag="BSU17760" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10762253, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative spore germination integral inner membrane protein" /protein_id="NP_389659.1" /db_xref="EnsemblGenomes-Gn:BSU17760" /db_xref="EnsemblGenomes-Tr:CAB13660" /db_xref="GOA:O31809" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004761" /db_xref="SubtiList:BG13442" /db_xref="UniProtKB/Swiss-Prot:O31809" /translation="MFSPTSKITTAQATIIIINYMLAAGVLTLPRTVTEQTQSPDGWI SVLLGGVLAVIAGMIIAKLSQQYPKETFYEYSRHIVGKWLGHLISIVFITYFLALGAF EVRVMSEIVDFFLLEGTPSWAIIMTVLWIGLYSITQGLDPIARLFEMIFPITVIIFLT IALMSLGIFEINNLRPVLGDGIMPVLRGVKTTNLSFTCSEIMFILVAFMKKPKNAVKA VVIGTGVVTSFYMITMIMVIGALSVEGVVTRTWPGLDLMRSFEIPGLIFERFESFLLV IWIMQLFATFIITFYAASLGVSQVFKKKPLSCMFGLLPVIYILSCMPKNENDVFILGD TVSHIALYIFGALPILLLVISKWRKRGEK*" /label="yndE CDS" gene 1736566..1737657 /gene="yndE" /locus_tag="BSU_17760" /old_locus_tag="BSU17760" /label="yndE gene" CDS 1737647..1738861 /gene="yndF" /locus_tag="BSU_17770" /old_locus_tag="BSU17770" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10762253, 27208128; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative spore germination lipoprotein" /protein_id="NP_389660.1" /db_xref="EnsemblGenomes-Gn:BSU17770" /db_xref="EnsemblGenomes-Tr:CAB13661" /db_xref="GOA:O31810" /db_xref="InterPro:IPR008844" /db_xref="SubtiList:BG13443" /db_xref="UniProtKB/Swiss-Prot:O31810" /translation="MKSKLKRQLPAMVIVCLLMICVTGCWSSREIEDLGLTFAIAIDK GKETNTEKELKEEGGSYPKKDNITLTYQFVNEKAAGAGTSGGGGSGQGAQKAYINISE TGDSLQQIGSEVALRRDREVFSPHLKVVVMSEDVLHTFPIDEMLDQFFRDNEIRLSCL VLSAKGEARDALQLKENGEIPAFRLIGLGENEHKVSRILPPMTLAKLIGKLHSGSSFL LQNVVAANGAVKYSGAAVINGKSKKMIGTLNEYETEGITWIRGEGKGGVVKSHDKKSQ QTLAYDINKIKSRIQPIVKGKDISFHVDIESEGDLVENWNTKEALDTQFIDRLETTIE NEVKKIVGQVLKKIQHDYKADVAGFDESFRLTYPHLWKRVKNNWDDTFSKADITYSVN VTITHFGTVKTQ*" /label="yndF CDS" gene 1737647..1738861 /gene="yndF" /locus_tag="BSU_17770" /old_locus_tag="BSU17770" /label="yndF gene" promotor_-35 1738939..1738946 /Source="Nicolas_upshift_promotors" /id="U1426" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.534465534465534" /psig="0.98001998001998" /xcortree=2419 /SigmaFactorBS="ttaggataaagatactttttttggagaGATATACActtttca aatcgacCAATATGCTAATATAGGAATtgcttgaaatagaagggagaaggggctgtga g" /listShort="yndG, yndH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1738961..1738980 /Source="Nicolas_upshift_promotors" /id="U1426" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.534465534465534" /psig="0.98001998001998" /xcortree=2419 /SigmaFactorBS="ttaggataaagatactttttttggagaGATATACActtttca aatcgacCAATATGCTAATATAGGAATtgcttgaaatagaagggagaaggggctgtga g" /listShort="yndG, yndH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1738972 /Source="Nicolas_upshifts" /id="U1426" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.534465534465534" /psig="0.98001998001998" /xcortree=2419 /SigmaFactorBS="ttaggataaagatactttttttggagaGATATACActtttca aatcgacCAATATGCTAATATAGGAATtgcttgaaatagaagggagaaggggctgtga g" /listShort="yndG, yndH" /GFF_Attribute="listLong" /label="upshifts" CDS 1739008..1739814 /gene="yndG" /locus_tag="BSU_17780" /old_locus_tag="BSU17780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11737947, 22333191, 27435445" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389661.1" /db_xref="EnsemblGenomes-Gn:BSU17780" /db_xref="EnsemblGenomes-Tr:CAB13662" /db_xref="GOA:O31811" /db_xref="SubtiList:BG13444" /db_xref="UniProtKB/Swiss-Prot:O31811" /translation="MRQKPIYVEIEMKSDLDTLWEYTQNPSLHKEWDLRFSNITYLNS QPCEKQKFLYETRVGFGLKVSGTGETVGVFNKCSSERSSSLAFGSDHPLSLIRHGSGY WKYIQRENGKMTFLTQYQYKTAYGLLGRWIDRLLFRPLLGWATAWSFDALRLWVEQNK HPKRFIRSAIIYVFMCLFFSLFWFYQGFAGVKTSILTGTAEIGLAILWLLPLKRKWII HGVQACIFAGFACLGSEIFMWVLLSVFSAASGALSLQLPSARRTKRKRKK*" /label="yndG CDS" gene 1739008..1739814 /gene="yndG" /locus_tag="BSU_17780" /old_locus_tag="BSU17780" /label="yndG gene" S_feature complement(1739622..1740720) /Source="Nicolas_S_feature" /locus_tag="new_1912142_1913240_c" /HighExp="S8, S6, S7, S5, T0.30H, T2.0H, GM 150, BT, T1.30H, T-4.40H" /AntisenseName="yndH" /AntisenseCor="-0.58089150558713998" /AntisenseRegPval="-24.9" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S651" CDS 1739819..1740436 /gene="yndH" /locus_tag="BSU_17790" /old_locus_tag="BSU17790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389662.1" /db_xref="EnsemblGenomes-Gn:BSU17790" /db_xref="EnsemblGenomes-Tr:CAB13663" /db_xref="InterPro:IPR025311" /db_xref="SubtiList:BG13445" /db_xref="UniProtKB/Swiss-Prot:O31812" /translation="MSSIYEKSIINYHLLHPKLQKRYQLDGSHTFSGTGTMSEISGGS FLVRMLLKLGVFFRCFFSERGKDIPFTIQNRTCLLKSQHTGIEWNRTFFFKGKKRFFD ALMIYDEKENRILDFFGKPHLLLSVLTFEASLDGSLTITSGKQWLLICGKRIPLPKWL TGTSEVCETFDEKKNCFTIEVHVQNTILGTLFFYKGTFQEEERES*" /label="yndH CDS" gene 1739819..1740436 /gene="yndH" /locus_tag="BSU_17790" /old_locus_tag="BSU17790" /label="yndH gene" CDS 1740433..1742073 /gene="yndJ" /locus_tag="BSU_17800" /old_locus_tag="BSU17800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12618455, 15849754, 16850406, 28615734; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_389663.1" /db_xref="EnsemblGenomes-Gn:BSU17800" /db_xref="EnsemblGenomes-Tr:CAB13664" /db_xref="GOA:O31813" /db_xref="InterPro:IPR025450" /db_xref="SubtiList:BG13446" /db_xref="UniProtKB/Swiss-Prot:O31813" /translation="MKRNGIVSALCFIGFLAAEAPDISVAEALVLLSILFFVPGIFPF VFRQSPVRAAQFMENGLIQCYPVAAFFAVLALVTEVGGFALIWWMYTVFNALYAILRL WETKIHRIEETSVLFGLIYLAGGGFWFFAYAAHLQIMQFGPLIILLTAVHFHYSAFLI PIFNGLLGRTIRKHRMLYSWITWVILLSPLLIALGITYSKTLDVIAVSIYMAAIYLHA FLVFTAAFRTKTGTFLIRLSSAVLMITIAFSMIYSFGVFRQEVTLTINQMIWIHGFVN AFGVILPALIGWRIEDAKPFDADSVKTFSRIYGKRKIGEEFLANIQAENNARYSGLVD DMGSLRSKDFSPEKLAPLILSFYEQTIEYNIKAKVTWSTWFRPLAIIYEWFSRRIGQI HLSTNPDWYRMYSKIKGVHSKKDGRERVRAWIRTNEKNETIFTALYSVYRSNGEGYMN ISLPLPFSSMTGILKPYHHQEKLVLTSRRRKSRAGDEGIYLQTRAGTCPLPLSETFLI EAVHDNKLTAVHHMWLFGIKFLTVHYSITHINQPIERT*" /label="yndJ CDS" gene 1740433..1742073 /gene="yndJ" /locus_tag="BSU_17800" /old_locus_tag="BSU17800" /label="yndJ gene" promotor_-10 complement(1740707..1740726) /Source="Nicolas_upshift_promotors" /id="U1427" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=1248 /SigmaFactorBS="caaaactgatgtctcttcgattctatgtatctTTGTTTCCCa aaggcggaggatCGCATACAATGCATTAAAAActgtgtacatccaccagataagtgcg a" /listShort="S651" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1740720) /Source="Nicolas_upshifts" /id="U1427" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=1248 /SigmaFactorBS="caaaactgatgtctcttcgattctatgtatctTTGTTTCCCa aaggcggaggatCGCATACAATGCATTAAAAActgtgtacatccaccagataagtgcg a" /listShort="S651" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1740740..1740748) /Source="Nicolas_upshift_promotors" /id="U1427" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=1248 /SigmaFactorBS="caaaactgatgtctcttcgattctatgtatctTTGTTTCCCa aaggcggaggatCGCATACAATGCATTAAAAActgtgtacatccaccagataagtgcg a" /listShort="S651" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1741713..1742479) /Source="Nicolas_S_feature" /locus_tag="new_1914233_1914999_c" /HighExp="T2.0H, T1.30H, T2.30H, GM 150, T3.30H, T1.0H, C30, T3.0H, T4.0H, T0.30H" /AntisenseName="yndK" /AntisenseCor="-0.33555507319526101" /AntisenseRegPval="-7.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S652" CDS 1742110..1742475 /gene="yndK" /locus_tag="BSU_17810" /old_locus_tag="BSU17810" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage/plasmid replication protein" /protein_id="NP_389664.1" /db_xref="EnsemblGenomes-Gn:BSU17810" /db_xref="EnsemblGenomes-Tr:CAB13665" /db_xref="GOA:O31814" /db_xref="SubtiList:BG13447" /db_xref="UniProtKB/Swiss-Prot:O31814" /translation="MNCFKILHRIKTGKEGFMVFYISLFLILWLAAGFAVGMKQVYVD QLFDKAVIERLEKEANDHGHADRMIKQRVLYIAAVTVSGFISVYYEMKTIPQRRNIRK IEKNIMKLNQAKKRRMKRK*" /label="yndK CDS" gene 1742110..1742475 /gene="yndK" /locus_tag="BSU_17810" /old_locus_tag="BSU17810" /label="yndK gene" downshifts 1742452 /Source="Nicolas_upshifts" /id="D970" /incds=0 /nref=166 /ntot=243 /MaxReadThrough="2.62352" /MaxDrop="5.68917" /score="15.340233" /energy="-10.4" /TU="NA" /idTUdmin="U1426" /TUdmin=2226 /isTUend="FALSE" /label="downshifts" misc_RNA complement(1742472..1742752) /gene="surA" /locus_tag="BSU_misc_RNA_72" /product="small untranslated RNA controlled by sporulation" /experiment="publication(s) with functional evidences, PMID:16385044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16385044; Product type n: RNA" /label="surA RNA" gene complement(1742472..1742752) /gene="surA" /locus_tag="BSU_misc_RNA_72" /label="surA gene" S_feature complement(1742481..1742612) /Source="Nicolas_S_feature" /locus_tag="new_1915001_1915132_c" /HighExp="B60, T2.0H, T1.30H, T1.0H, T2.30H, M9-stat, LoTm, S5, T3.30H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.443, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S653" downshifts complement(1742524) /Source="Nicolas_upshifts" /id="D971" /incds=0 /nref=21 /ntot=129 /MaxReadThrough="4.91485" /MaxDrop="4.94426" /score="14.7738511" /energy="-10.4" /TU="U1429,U1431" /idTUdmin="U1429" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" promotor_-35 1742572..1742581 /Source="Nicolas_upshift_promotors" /id="U1428" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.934065934065934" /psig="0.934065934065934" /xcortree=1253 /SigmaFactorBS="agcttacttttcataaattcaaaaatgagaagAACAGCGCCC gggctaatggtatATAATATTGTGAATTTAACAaaaatttaacaaggaggacgagaga a" /listShort="S654, yndL, S657, fosB, S658, S659" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1742594..1742603) /Source="Nicolas_upshift_promotors" /id="U1429" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.442557442557443" /psig="0.442557442557443" /xcortree=1043 /SigmaFactorBS="gaatgtaggtctctttgaggctttagcacgaattctctcgtc ctccttgttaaatttttgttaaattcaCAATATTATAtaccattagcccgggcgctgt t" /listShort="S653" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 1742595..1742614 /Source="Nicolas_upshift_promotors" /id="U1428" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.934065934065934" /psig="0.934065934065934" /xcortree=1253 /SigmaFactorBS="agcttacttttcataaattcaaaaatgagaagAACAGCGCCC gggctaatggtatATAATATTGTGAATTTAACAaaaatttaacaaggaggacgagaga a" /listShort="S654, yndL, S657, fosB, S658, S659" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1742600 /Source="Nicolas_upshifts" /id="U1428" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.934065934065934" /psig="0.934065934065934" /xcortree=1253 /SigmaFactorBS="agcttacttttcataaattcaaaaatgagaagAACAGCGCCC gggctaatggtatATAATATTGTGAATTTAACAaaaatttaacaaggaggacgagaga a" /listShort="S654, yndL, S657, fosB, S658, S659" /GFF_Attribute="listLong" /label="upshifts" S_feature 1742602..1742700 /Source="Nicolas_S_feature" /locus_tag="new_1915122_1915220" /HighExp="S8, S6, S7, BT, S5, G/S, B36, C30, Pyr, UNK1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.52117199999999997" /TUshortSig="SigK" /TUshortPSig="0.934" /TUlongSig="NA" /TUlongPSig="NA" /label="S654" upshifts complement(1742612) /Source="Nicolas_upshifts" /id="U1429" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.442557442557443" /psig="0.442557442557443" /xcortree=1043 /SigmaFactorBS="gaatgtaggtctctttgaggctttagcacgaattctctcgtc ctccttgttaaatttttgttaaattcaCAATATTATAtaccattagcccgggcgctgt t" /listShort="S653" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1742614..1742744) /Source="Nicolas_S_feature" /locus_tag="new_1915134_1915264_c" /HighExp="T2.0H, T1.30H, M9-stat, T2.30H, T1.0H, B60, LoTm, T4.0H, T3.30H, T0.30H" /AntisenseName="yndL" /AntisenseCor="0.22331158442510801" /AntisenseRegPval="-3.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S655" CDS 1742701..1743459 /gene="pghL" /locus_tag="BSU_17820" /old_locus_tag="BSU17820" /EC_number="3.4.19.-" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:26158264" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 26158264; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="phage gamma-polyglutamate hydrolase" /protein_id="NP_389665.1" /db_xref="EnsemblGenomes-Gn:BSU17820" /db_xref="EnsemblGenomes-Tr:CAB13666" /db_xref="GOA:O31815" /db_xref="InterPro:IPR008585" /db_xref="SubtiList:BG13448" /db_xref="UniProtKB/Swiss-Prot:O31815" /translation="MKPAKVSLLRRLLHSLKHVDCNIAKRFPSTIKIVKLLMIFMVFT PISSIYAEDVYQNFEELKNNEDPSDYGVVTKETGSPVLVLAIHGGGIEGGTSEVAREL SKEYSMYLFEGLKSAGNSVLHITSTHFDEPRALKMTGNHEYVISLHGYAEEDQQIEVG GTDRVRAADLVEKLQHAGFPAVLLNMDHPHAGVSPNNIANKSKTGLSIQIEMSTGFRK SLFGIFSLKSRAVTQNERFYEFTEVMFRFLKNSY*" /label="pghL CDS" gene 1742701..1743459 /gene="pghL" /locus_tag="BSU_17820" /old_locus_tag="BSU17820" /label="pghL gene" upshifts 1742734 /Source="Nicolas_upshifts" /id="U1430" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.308691308691309" /psig="0.211788211788212" /xcortree=1323 /SigmaFactorBS="gttgatttggacttagaggcggagtagatgaaaccggccaaa gtatccctgctCcGccgtttgctccattccttgaagcatgttgattgtaacatagcca a" /listShort="yndL, S657, fosB, S658, S659" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1742750..1742769) /Source="Nicolas_upshift_promotors" /id="U1431" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=481 /SigmaFactorBS="caataattttacaattttaaTAGTTGATggaaaacgtttggc TATGTTACAATCAACATGCTtcaaggaatggagcaaacggcggagcagggatactttg g" /listShort="S655, S653, S652" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1742751) /Source="Nicolas_upshifts" /id="U1431" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=481 /SigmaFactorBS="caataattttacaattttaaTAGTTGATggaaaacgtttggc TATGTTACAATCAACATGCTtcaaggaatggagcaaacggcggagcagggatactttg g" /listShort="S655, S653, S652" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1742784..1742791) /Source="Nicolas_upshift_promotors" /id="U1431" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=481 /SigmaFactorBS="caataattttacaattttaaTAGTTGATggaaaacgtttggc TATGTTACAATCAACATGCTtcaaggaatggagcaaacggcggagcagggatactttg g" /listShort="S655, S653, S652" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1743274..1743485) /Source="Nicolas_S_feature" /locus_tag="new_1915794_1916005_c" /HighExp="S8, S5, S7, S6, S4, ferm, nit, BT, Pyr, G/S" /AntisenseName="yndL" /AntisenseCor="0.82198535504067005" /AntisenseRegPval="-66.5" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.515" /TUlongSig="NA" /TUlongPSig="NA" /label="S656" downshifts 1743438 /Source="Nicolas_upshifts" /id="D972" /incds=0 /nref=3 /ntot=23 /MaxReadThrough="4.17889" /MaxDrop="5.0493" /score="15.340233" /energy="-10.4" /TU="U1428,U1430" /idTUdmin="U1428" /TUdmin="-1540" /isTUend="FALSE" /label="downshifts" S_feature 1743483..1744102 /Source="Nicolas_S_feature" /locus_tag="new_1916003_1916622" /HighExp="S8, S6, S7, S5, C30, BT, G135, LBGstat, GM 150, M/G" /AntisenseName="yndM" /AntisenseCor="0.75549671487088998" /AntisenseRegPval="-50.2" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigK" /TUshortPSig="0.212, 0.934" /TUlongSig="NA" /TUlongPSig="NA" /label="S657" CDS complement(1743486..1744025) /gene="yndM" /locus_tag="BSU_17830" /old_locus_tag="BSU17830" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_389666.1" /db_xref="EnsemblGenomes-Gn:BSU17830" /db_xref="EnsemblGenomes-Tr:CAB13667" /db_xref="GOA:O31816" /db_xref="InterPro:IPR019649" /db_xref="SubtiList:BG13449" /db_xref="UniProtKB/Swiss-Prot:O31816" /translation="MTIMNGFELHYLSFVYAQEFSSKNNNLGGQMKHIIALASKIAFT LALLYVILDRVYHASFLSVMFIALFLGFVSYLSGDMLVLPRTNNITASLADFGLSFVI LWVFVLTQTRNDFSPFGAALLSAACLTVFEYFFHRYLLKNVLDENFRNELSARDNTLQ YQTEAADELFPETKEKHKE*" /label="yndM CDS" gene complement(1743486..1744025) /gene="yndM" /locus_tag="BSU_17830" /old_locus_tag="BSU17830" /label="yndM gene" promotor_-10 complement(1744026..1744040) /Source="Nicolas_upshift_promotors" /id="U1432" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.515484515484515" /psig="0.515484515484515" /xcortree=865 /SigmaFactorBS="taagaaagtttcatacagctgaaaaaaataccAGTGTAAaca aaaacggactGTTTAAAATAGTAACatgaccattatgaatggttttgaattgcattat t" /listShort="yndM, S656" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1744032) /Source="Nicolas_upshifts" /id="U1432" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.515484515484515" /psig="0.515484515484515" /xcortree=865 /SigmaFactorBS="taagaaagtttcatacagctgaaaaaaataccAGTGTAAaca aaaacggactGTTTAAAATAGTAACatgaccattatgaatggttttgaattgcattat t" /listShort="yndM, S656" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1744054..1744060) /Source="Nicolas_upshift_promotors" /id="U1432" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.515484515484515" /psig="0.515484515484515" /xcortree=865 /SigmaFactorBS="taagaaagtttcatacagctgaaaaaaataccAGTGTAAaca aaaacggactGTTTAAAATAGTAACatgaccattatgaatggttttgaattgcattat t" /listShort="yndM, S656" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1744080..1744089 /Source="Nicolas_upshift_promotors" /id="U1433" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1668 /SigmaFactorBS="ccgtttttgtttacactggtatttttttcagctgtaTGAAAC TTTCttatgaaaaaagTCGTATATGTGGATGAtcagctttcaaggggggaatgatttg t" /listShort="fosB, S658, S659" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1744102..1744117 /Source="Nicolas_upshift_promotors" /id="U1433" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1668 /SigmaFactorBS="ccgtttttgtttacactggtatttttttcagctgtaTGAAAC TTTCttatgaaaaaagTCGTATATGTGGATGAtcagctttcaaggggggaatgatttg t" /listShort="fosB, S658, S659" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1744104 /Source="Nicolas_upshifts" /id="U1433" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1668 /SigmaFactorBS="ccgtttttgtttacactggtatttttttcagctgtaTGAAAC TTTCttatgaaaaaagTCGTATATGTGGATGAtcagctttcaaggggggaatgatttg t" /listShort="fosB, S658, S659" /GFF_Attribute="listLong" /label="upshifts" CDS 1744143..1744577 /gene="fosB" /locus_tag="BSU_17840" /old_locus_tag="BSU17840" /EC_number="2.5.1.-" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11244082, 16399398, 19763274, 23256780" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11244082, 16399398, 19763274, 23256780; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="magnesium-dependent bacillithiol-transferase" /protein_id="NP_389667.1" /db_xref="EnsemblGenomes-Gn:BSU17840" /db_xref="EnsemblGenomes-Tr:CAB13668" /db_xref="GOA:O31817" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR022858" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG13450" /db_xref="UniProtKB/Swiss-Prot:O31817" /translation="MEIKGINHLLFSVSHLDTSIDFYQKVFGAKLLVKGRTTAYFDMN GIWLALNEEPDIPRNDIKLSYTHIAFTIEDHEFEEMSAKLKRLHVNILPGRERDERDR KSIYFTDPDGHKFEFHTGTLQDRLRYYKQEKTHMHFYDETAF*" /label="fosB CDS" gene 1744143..1744577 /gene="fosB" /locus_tag="BSU_17840" /old_locus_tag="BSU17840" /label="fosB gene" CDS 1744435..1744782 /gene="yzzP" /locus_tag="BSU_17845" /old_locus_tag="BSU17845" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 27144405" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_009513960.1" /translation="MNAIENQFILPTLTATNLNFIPEPFKTGFDITNKKKRICTFMMK RPFDSTTIFHIRLNLKKGVGGDFMFGEGFYPTCSTMPYLLNCTSDWVKVKLKYTLHYI LYEESELFYQMLN*" /label="yzzP CDS" gene 1744435..1744782 /gene="yzzP" /locus_tag="BSU_17845" /old_locus_tag="BSU17845" /label="yzzP gene" S_feature 1744578..1744910 /Source="Nicolas_S_feature" /locus_tag="new_1917098_1917430" /HighExp="T0.30H, T1.0H, T1.30H, T2.0H, T-0.40H, T0.0H, T-1.10H, T2.30H, Salt, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.66836499999999999" /TUshortSig="SigWXY, Sig-, SigK" /TUshortPSig="1, 0.212, 0.934" /TUlongSig="NA" /TUlongPSig="NA" /label="S658" promotor_-35 1744869..1744878 /Source="Nicolas_upshift_promotors" /id="U1434" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=425 /SigmaFactorBS="ttccacgacctaaaaaaTGAAACGTTTttaagaagatgGCGT CTAATATTCTAAatgttcatattttgataaaagtttcctaaaggaaagaaaatttctt g" /listShort="S659" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1744890..1744905 /Source="Nicolas_upshift_promotors" /id="U1434" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=425 /SigmaFactorBS="ttccacgacctaaaaaaTGAAACGTTTttaagaagatgGCGT CTAATATTCTAAatgttcatattttgataaaagtttcctaaaggaaagaaaatttctt g" /listShort="S659" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1744912..1745090 /Source="Nicolas_S_feature" /locus_tag="new_1917432_1917610" /HighExp="T0.30H, T1.0H, T1.30H, T2.0H, T-0.40H, T-1.10H, T0.0H, T2.30H, T3.0H, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY, SigWXY, Sig-, SigK" /TUshortPSig="0.99, 1, 0.212, 0.934" /TUlongSig="NA" /TUlongPSig="NA" /label="S659" upshifts 1744912 /Source="Nicolas_upshifts" /id="U1434" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=425 /SigmaFactorBS="ttccacgacctaaaaaaTGAAACGTTTttaagaagatgGCGT CTAATATTCTAAatgttcatattttgataaaagtttcctaaaggaaagaaaatttctt g" /listShort="S659" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 1744981..1745060 /gene="ncrF" /locus_tag="BSU_misc_RNA_73" /product="putative conserved small untranslated RNA" /experiment="publication(s) with functional evidences, PMID:20525796" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20525796; Product type n: RNA" /label="ncrF RNA" gene 1744981..1745060 /gene="ncrF" /locus_tag="BSU_misc_RNA_73" /label="ncrF gene" downshifts 1745047 /Source="Nicolas_upshifts" /id="D973" /incds=0 /nref=16 /ntot=188 /MaxReadThrough="2.99425" /MaxDrop="4.30173" /score="-1.31226475" /energy="-14.3" /TU="U1433" /idTUdmin="U1434" /TUdmin=3 /isTUend="TRUE" /label="downshifts" CDS complement(1745119..1745736) /gene="lexA" /locus_tag="BSU_17850" /old_locus_tag="BSU17850" /function="16.8: Protect" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14652736, 16267290, 16269821, 16855250, 17042786, 19684115, 24285298" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14652736, 16267290, 16269821, 16855250, 17042786, 19684115, 24285298; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of the SOS regulon" /protein_id="NP_389668.1" /db_xref="EnsemblGenomes-Gn:BSU17850" /db_xref="EnsemblGenomes-Tr:CAB13669" /db_xref="GOA:P31080" /db_xref="InterPro:IPR006197" /db_xref="InterPro:IPR006199" /db_xref="InterPro:IPR006200" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR015927" /db_xref="InterPro:IPR036286" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10678" /db_xref="UniProtKB/Swiss-Prot:P31080" /translation="MTKLSKRQLDILRFIKAEVKSKGYPPSVREIGEAVGLASSSTVH GHLARLETKGLIRRDPTKPRAIEILDEEVDIPQSQVVNVPVIGKVTAGSPITAVENIE EYFPLPDRMVPPDEHVFMLEIMGDSMIDAGILDKDYVIVKQQNTANNGEIVVAMTEDD EATVKRFYKEDTHIRLQPENPTMEPIILQNVSILGKVIGVFRTVH*" /label="lexA CDS" gene complement(1745119..1745736) /gene="lexA" /locus_tag="BSU_17850" /old_locus_tag="BSU17850" /label="lexA gene" downshifts complement(1745120) /Source="Nicolas_upshifts" /id="D974" /incds=0 /nref=186 /ntot=254 /MaxReadThrough="2.74616" /MaxDrop="7.90985" /score="8.16083322" /energy="-16.3" /TU="U1435" /idTUdmin="U1435" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1745760..1745779) /Source="Nicolas_upshift_promotors" /id="U1435" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.659340659340659" /psig=1 /xcortree=2083 /SigmaFactorBS="tatacgaacaaacgtttctgtcaattgttttttcgaacctaT GTTTGTActgtaaggaaaatCATGCTATAATCTTCTTAAAatcgacgttttgaggtgc g" /listShort="lexA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1745781) /Source="Nicolas_upshifts" /id="U1435" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.659340659340659" /psig=1 /xcortree=2083 /SigmaFactorBS="tatacgaacaaacgtttctgtcaattgttttttcgaacctaT GTTTGTActgtaaggaaaatCATGCTATAATCTTCTTAAAatcgacgttttgaggtgc g" /listShort="lexA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1745793..1745800) /Source="Nicolas_upshift_promotors" /id="U1435" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.659340659340659" /psig=1 /xcortree=2083 /SigmaFactorBS="tatacgaacaaacgtttctgtcaattgttttttcgaacctaT GTTTGTActgtaaggaaaatCATGCTATAATCTTCTTAAAatcgacgttttgaggtgc g" /listShort="lexA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1745816..1745823 /Source="Nicolas_upshift_promotors" /id="U1436" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=1508 /SigmaFactorBS="gcatgattttccttacagtacaaacataggttcgaaaaaacA ATTGACAgaaacgtttgttcGTATATACTGAAATTATAAAaatgcgaacaaacattcc t" /listShort="yneA, yneB, ynzC, S660, tkt" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1745835 /Source="Nicolas_upshifts" /id="U1436" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=1508 /SigmaFactorBS="gcatgattttccttacagtacaaacataggttcgaaaaaacA ATTGACAgaaacgtttgttcGTATATACTGAAATTATAAAaatgcgaacaaacattcc t" /listShort="yneA, yneB, ynzC, S660, tkt" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1745837..1745856 /Source="Nicolas_upshift_promotors" /id="U1436" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=1508 /SigmaFactorBS="gcatgattttccttacagtacaaacataggttcgaaaaaacA ATTGACAgaaacgtttgttcGTATATACTGAAATTATAAAaatgcgaacaaacattcc t" /listShort="yneA, yneB, ynzC, S660, tkt" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1745886..1746203 /gene="dinK" /locus_tag="BSU_17860" /old_locus_tag="BSU17860" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12581363, 16267290, 16549676, 20400548, 20807205, 23728628" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12581363, 16267290, 16549676, 20400548, 20807205, 23728628; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="cell division inhibitor" /protein_id="NP_389669.1" /db_xref="EnsemblGenomes-Gn:BSU17860" /db_xref="EnsemblGenomes-Tr:CAB13670" /db_xref="GOA:Q45056" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR022887" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG11820" /db_xref="UniProtKB/Swiss-Prot:Q45056" /translation="MIMSKESIIFVGLFTVILSAVILMLSYTSSGQELNQYVKIEVQQ GDTLWSIADQVADTKKINKNDFIEWVADKNQLQTSDIQPGDELVIPLKKKHQDAYELA TVR*" /label="dinK CDS" gene 1745886..1746203 /gene="dinK" /locus_tag="BSU_17860" /old_locus_tag="BSU17860" /label="dinK gene" promotor_-10 complement(1745903..1745921) /Source="Nicolas_upshift_promotors" /id="U1437" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2844 /SigmaFactorBS="atatgacagcataaggataaccgcGCTCAAAAtcactgtaaa cagACCGACAAAAATAATAGATtctttactcatgatcataacctccaacaggaatgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1745906) /Source="Nicolas_upshifts" /id="U1437" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2844 /SigmaFactorBS="atatgacagcataaggataaccgcGCTCAAAAtcactgtaaa cagACCGACAAAAATAATAGATtctttactcatgatcataacctccaacaggaatgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1745935..1745942) /Source="Nicolas_upshift_promotors" /id="U1437" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2844 /SigmaFactorBS="atatgacagcataaggataaccgcGCTCAAAAtcactgtaaa cagACCGACAAAAATAATAGATtctttactcatgatcataacctccaacaggaatgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1746222..1746875 /gene="dinL" /locus_tag="BSU_17870" /old_locus_tag="BSU17870" /function="16.9: Replicate" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12581363, 16267290, 17020588, 19060143, 22933559; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative site-specific recombinase, resolvase" /protein_id="NP_389670.1" /db_xref="EnsemblGenomes-Gn:BSU17870" /db_xref="EnsemblGenomes-Tr:CAB13671" /db_xref="GOA:Q45057" /db_xref="InterPro:IPR006119" /db_xref="InterPro:IPR036162" /db_xref="SubtiList:BG11821" /db_xref="UniProtKB/Swiss-Prot:Q45057" /translation="MKALIYARVSTNKEQQETSLKRQEEELTAIAAENGMEVVKVISE KASGYEMDRDGVFELLDEIKNADIDVILVQDETRLGRGNAKIALLHCIYREGVKVYTT AHRGELELSEADSMVLEIVSIVEEYQRKIHNMKIRRGMKRAVKNGFKPQKNLKNQHGN SGKEKIEVPISEIVRLRANKLTFAEIAATLRGFGYDVSKATVHRRFQEYIENEETAE* " /label="dinL CDS" gene 1746222..1746875 /gene="dinL" /locus_tag="BSU_17870" /old_locus_tag="BSU17870" /label="dinL gene" promotor_-35 1746878..1746885 /Source="Nicolas_upshift_promotors" /id="U1438" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.965034965034965" /psig=1 /xcortree=2084 /SigmaFactorBS="gagaatgaagagactgcagagtgaatCAGTTGTAaaactttt tttgaTCTAGTACTATATAGACAAAatgcaataaaggagtttaacatgatttcaaacg c" /listShort="ynzC, S660, tkt" /listLong="yneE, yneF" /label="promotor_-35" promotor_-10 1746899..1746918 /Source="Nicolas_upshift_promotors" /id="U1438" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.965034965034965" /psig=1 /xcortree=2084 /SigmaFactorBS="gagaatgaagagactgcagagtgaatCAGTTGTAaaactttt tttgaTCTAGTACTATATAGACAAAatgcaataaaggagtttaacatgatttcaaacg c" /listShort="ynzC, S660, tkt" /listLong="yneE, yneF" /label="promotor_-10" upshifts 1746912 /Source="Nicolas_upshifts" /id="U1438" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.965034965034965" /psig=1 /xcortree=2084 /SigmaFactorBS="gagaatgaagagactgcagagtgaatCAGTTGTAaaactttt tttgaTCTAGTACTATATAGACAAAatgcaataaaggagtttaacatgatttcaaacg c" /listShort="ynzC, S660, tkt" /listLong="yneE, yneF" /label="upshifts" CDS 1746939..1747172 /gene="ynzC" /locus_tag="BSU_17880" /old_locus_tag="BSU17880" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12581363, 16267290, 18431750,19306341, 22333191, 22933559, 23099262" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389671.1" /db_xref="EnsemblGenomes-Gn:BSU17880" /db_xref="EnsemblGenomes-Tr:CAB13672" /db_xref="GOA:O31818" /db_xref="InterPro:IPR009242" /db_xref="PDB:2HEP" /db_xref="PDB:2JVD" /db_xref="PDB:3BHP" /db_xref="SubtiList:BG13466" /db_xref="UniProtKB/Swiss-Prot:O31818" /translation="MISNAKIARINELAAKAKAGVITEEEKAEQQKLRQEYLKGFRSS MKNTLKSVKIIDPEGNDVTPEKLKREQRNNKLH*" /label="ynzC CDS" gene 1746939..1747172 /gene="ynzC" /locus_tag="BSU_17880" /old_locus_tag="BSU17880" /label="ynzC gene" S_feature 1747173..1747308 /Source="Nicolas_S_feature" /locus_tag="new_1919693_1919828" /HighExp="M40t90, M40t45, dia15, C90, Etha, H2O2, T5.0H, Salt, dia5, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S660" promotor_-35 1747276..1747283 /Source="Nicolas_upshift_promotors" /id="U1439" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.976023976023976" /psig="0.999000999001" /xcortree=2357 /SigmaFactorBS="aagtttctctcaaatttaagctgaaaCAGTTGAGaaaaagtc gtcagACATTTATGATGTAAGGGTAcaacacataaggaaggggatttttatggataca a" /listShort="tkt, yneE" /listLong="yneF" /label="promotor_-35" promotor_-10 1747297..1747316 /Source="Nicolas_upshift_promotors" /id="U1439" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.976023976023976" /psig="0.999000999001" /xcortree=2357 /SigmaFactorBS="aagtttctctcaaatttaagctgaaaCAGTTGAGaaaaagtc gtcagACATTTATGATGTAAGGGTAcaacacataaggaaggggatttttatggataca a" /listShort="tkt, yneE" /listLong="yneF" /label="promotor_-10" upshifts 1747310 /Source="Nicolas_upshifts" /id="U1439" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.976023976023976" /psig="0.999000999001" /xcortree=2357 /SigmaFactorBS="aagtttctctcaaatttaagctgaaaCAGTTGAGaaaaagtc gtcagACATTTATGATGTAAGGGTAcaacacataaggaaggggatttttatggataca a" /listShort="tkt, yneE" /listLong="yneF" /label="upshifts" CDS 1747341..1749344 /gene="tktA" /locus_tag="BSU_17890" /old_locus_tag="BSU17890" /EC_number="2.2.1.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9696621, 12682299, 12882400, 27739585" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9696621, 12682299, 12882400, 27739585; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="transketolase" /protein_id="NP_389672.1" /db_xref="EnsemblGenomes-Gn:BSU17890" /db_xref="EnsemblGenomes-Tr:CAB13673" /db_xref="GOA:P45694" /db_xref="InterPro:IPR005474" /db_xref="InterPro:IPR005475" /db_xref="InterPro:IPR005478" /db_xref="InterPro:IPR009014" /db_xref="InterPro:IPR020826" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR033247" /db_xref="InterPro:IPR033248" /db_xref="SubtiList:BG11247" /db_xref="UniProtKB/Swiss-Prot:P45694" /translation="MDTIEKKSVATIRTLSIDAIEKANSGHPGMPMGAAPMAYTLWTK FMNVSPANPGWFNRDRFVLSAGHGSALLYSMLHLSGFDLSIEDLKGFRQWGSKTPGHP EFGHTAGVDATTGPLGQGIAMAVGMAIAERHLAETYNRDSFNVVDHYTYSICGDGDLM EGISSEAASLAGHLQLGRLIVLYDSNDISLDGDLDRSFSENVKQRFEAMNWEVLYVED GNNIEELTAAIEKARQNEKKPTLIEVKTTIGFGSPNRAGTSGVHGAPLGKEESKLTKE AYAWTYEEDFYVPSEVYEHFAVAVKESGEKKEQEWNAQFAKYKEVYPELAEQLELAIK GELPKDWDQEVPVYEKGSSLASRASSGEVLNGLAKKIPFFVGGSADLAGSNKTTIKNA GDFTAVDYSGKNFWFGVREFAMGAALNGMALHGGLRVFGGTFFVFSDYLRPAIRLAAL MGLPVTYVFTHDSIAVGEDGPTHEPVEQLASLRAMPNLSLIRPADGNETAAAWKLAVQ STDHPTALVLTRQNLPTIDQTSEEALAGVEKGAYVVSKSKNETPDALLIASGSEVGLA IEAQAELAKENIDVSVVSMPSMDRFEKQSDEYKNEVLPADVKKRLAIEMGSSFGWGKY TGLEGDVLGIDRFGASAPGETIINEYGFSVPNVVNRVKALINK*" /label="tktA CDS" gene 1747341..1749344 /gene="tktA" /locus_tag="BSU_17890" /old_locus_tag="BSU17890" /label="tktA gene" misc_feature complement(1747545..1747564) /Source="Nicolas_upshift_promotors" /id="U1440" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.713286713286713" /psig="0.78921078921079" /xcortree=31 /SigmaFactorBS="ccactggcggaatcccttaagatcttcaatactaagatcaaa cccgcttaaatgaagcATGCTGTATAATAGTGCTGAcccgtgtccagcagataaaaca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1747562) /Source="Nicolas_upshifts" /id="U1440" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.713286713286713" /psig="0.78921078921079" /xcortree=31 /SigmaFactorBS="ccactggcggaatcccttaagatcttcaatactaagatcaaa cccgcttaaatgaagcATGCTGTATAATAGTGCTGAcccgtgtccagcagataaaaca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1749334 /Source="Nicolas_upshifts" /id="D975" /incds=0 /nref=230 /ntot=257 /MaxReadThrough="4.5478" /MaxDrop="6.66676" /score="16.4587041" /energy="-10.6" /TU="U1439" /idTUdmin="U1436" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1749346..1750004) /Source="Nicolas_S_feature" /locus_tag="new_1921866_1922524_c" /HighExp="Lbstat, C30, Salt, BC, S7, LPhT, S8, M0t90, T-0.40H, Glucon" /AntisenseName="yneE" /AntisenseCor="4.3891878649396997E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.604, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S661" upshifts 1749444 /Source="Nicolas_upshifts" /id="U1441" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.783216783216783" /psig="0.996003996003996" /xcortree=441 /SigmaFactorBS="tgtttatccgacaaaaatagtattggctgtttaacagtaata gacaattctttcttttcttCTTTTGTATAATAGAGAGCAaatgaaatgctgctggaaa a" /listShort="yneE, yneF, S662, S663, ccdA, yneI" /listLong="yneJ" /label="upshifts" misc_feature 1749445..1749464 /Source="Nicolas_upshift_promotors" /id="U1441" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.783216783216783" /psig="0.996003996003996" /xcortree=441 /SigmaFactorBS="tgtttatccgacaaaaatagtattggctgtttaacagtaata gacaattctttcttttcttCTTTTGTATAATAGAGAGCAaatgaaatgctgctggaaa a" /listShort="yneE, yneF, S662, S663, ccdA, yneI" /listLong="yneJ" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 1749497..1749943 /gene="pcfA" /locus_tag="BSU_17900" /old_locus_tag="BSU17900" /experiment="publication(s) with functional evidences, PMID:19682252, 25041308, 22720735, 27489185" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19682252, 25041308, 22720735, 27489185; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor controlling DNA replication" /protein_id="NP_389673.1" /db_xref="EnsemblGenomes-Gn:BSU17900" /db_xref="EnsemblGenomes-Tr:CAB13674" /db_xref="GOA:P45707" /db_xref="InterPro:IPR019683" /db_xref="PDB:4TPS" /db_xref="SubtiList:BG11248" /db_xref="UniProtKB/Swiss-Prot:P45707" /translation="MERHYYTYLIKEEFANHYFGRESVMFELFQDYHWTSLEKQQYEM TEKQIQYITQPIPILHMHQRLKMNLNKTDYRQLDYIYRIALPKAKGHATFMMKEHMIE IVASGDYEAETIFFEVLRKVSPCFLAMDFNSKRYGWLNPVKERNFV*" /label="pcfA CDS" gene 1749497..1749943 /gene="pcfA" /locus_tag="BSU_17900" /old_locus_tag="BSU17900" /label="pcfA gene" misc_feature 1749967..1749986 /Source="Nicolas_upshift_promotors" /id="U1442" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=2574 /SigmaFactorBS="atccggtgaaagaaagaaattttgtctaaaaccgaagaaaaa gagatgtaaaTGTTGTATAATAGCTTTTGGtttagtacactttaaactagacaacatg a" /listShort="yneF, S662, S663, ccdA, yneI, yneJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1749975 /Source="Nicolas_upshifts" /id="U1442" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=2574 /SigmaFactorBS="atccggtgaaagaaagaaattttgtctaaaaccgaagaaaaa gagatgtaaaTGTTGTATAATAGCTTTTGGtttagtacactttaaactagacaacatg a" /listShort="yneF, S662, S663, ccdA, yneI, yneJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1749986..1750003) /Source="Nicolas_upshift_promotors" /id="U1443" /multdbtbs="-" /comp="M15" /sig="SigA" /pcomp="0.394605394605395" /psig="0.604395604395604" /xcortree=3127 /SigmaFactorBS="aacaacgcccactaggatgccaacccataaagtcatttTATT TcctccttcatgttgtctaGTTTAAAGTGTACTAAACcaaaagctattatacaacatt t" /listShort="S661" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1750004) /Source="Nicolas_upshifts" /id="U1443" /multdbtbs="-" /comp="M15" /sig="SigA" /pcomp="0.394605394605395" /psig="0.604395604395604" /xcortree=3127 /SigmaFactorBS="aacaacgcccactaggatgccaacccataaagtcatttTATT TcctccttcatgttgtctaGTTTAAAGTGTACTAAACcaaaagctattatacaacatt t" /listShort="S661" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1750022..1750026) /Source="Nicolas_upshift_promotors" /id="U1443" /multdbtbs="-" /comp="M15" /sig="SigA" /pcomp="0.394605394605395" /psig="0.604395604395604" /xcortree=3127 /SigmaFactorBS="aacaacgcccactaggatgccaacccataaagtcatttTATT TcctccttcatgttgtctaGTTTAAAGTGTACTAAACcaaaagctattatacaacatt t" /listShort="S661" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1750029..1750247 /gene="yneF" /locus_tag="BSU_17910" /old_locus_tag="BSU17910" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyltransferase" /protein_id="NP_389674.1" /db_xref="EnsemblGenomes-Gn:BSU17910" /db_xref="EnsemblGenomes-Tr:CAB13675" /db_xref="GOA:P45708" /db_xref="InterPro:IPR005359" /db_xref="SubtiList:BG11249" /db_xref="UniProtKB/Swiss-Prot:P45708" /translation="MTLWVGILVGVVALLIGVALGFFIARKYMMSYLKKNPPINEQML RMMMMQMGMKPSQKKINQMMKAMNNQTK*" /label="yneF CDS" gene 1750029..1750247 /gene="yneF" /locus_tag="BSU_17910" /old_locus_tag="BSU17910" /label="yneF gene" downshifts 1750259 /Source="Nicolas_upshifts" /id="D976" /incds=0 /nref=243 /ntot=260 /MaxReadThrough="3.51446" /MaxDrop="7.54782" /score="0.133420982" /energy="-4.3" /TU="U1441,U1442" /idTUdmin="U1439" /TUdmin=287 /isTUend="FALSE" /label="downshifts" S_feature 1750304..1750603 /Source="Nicolas_S_feature" /locus_tag="new_1922824_1923123" /HighExp="S4, S3, S5, G180, S8, T5.0H, LoTm, G135, S6, S7" /AntisenseName="ynzD" /AntisenseCor="-0.33023056016157298" /AntisenseRegPval="-7.5" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S662" CDS complement(1750321..1750494) /gene="spo0D" /locus_tag="BSU_17920" /old_locus_tag="BSU17920" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11679073, 15187183, 17350627, 22303282, 23378509, 27965289" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11679073, 15187183, 17350627, 22303282, 23378509, 27965289; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="Spo0A-P phosphatase" /protein_id="NP_389675.1" /db_xref="EnsemblGenomes-Gn:BSU17920" /db_xref="EnsemblGenomes-Tr:CAB13676" /db_xref="GOA:O31819" /db_xref="InterPro:IPR018540" /db_xref="InterPro:IPR037208" /db_xref="SubtiList:BG13467" /db_xref="UniProtKB/Swiss-Prot:O31819" /translation="MIREHLLKEIEKKRAELLQIVMANGMTSHITIELSQELDHLLIQ YQKQRLRAVAGDE*" /label="spo0D CDS" gene complement(1750321..1750494) /gene="spo0D" /locus_tag="BSU_17920" /old_locus_tag="BSU17920" /label="spo0D gene" downshifts complement(1750334) /Source="Nicolas_upshifts" /id="D977" /incds=0 /nref=109 /ntot=219 /MaxReadThrough="4.0851" /MaxDrop="5.22565" /score="1.92055758" /energy="-4.3" /TU="U1444,U1446" /idTUdmin="U1444" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1750532..1750551) /Source="Nicolas_upshift_promotors" /id="U1444" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.784215784215784" /psig="0.998001998001998" /xcortree=568 /SigmaFactorBS="ttgacattgagacattatactccttctCATTTGAAaattagt ataaatATGGATATAATATAAACATTcactttgaagatctaatgtatgaaaggataca t" /listShort="ynzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1750539) /Source="Nicolas_upshifts" /id="U1444" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.784215784215784" /psig="0.998001998001998" /xcortree=568 /SigmaFactorBS="ttgacattgagacattatactccttctCATTTGAAaattagt ataaatATGGATATAATATAAACATTcactttgaagatctaatgtatgaaaggataca t" /listShort="ynzD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1750565..1750572) /Source="Nicolas_upshift_promotors" /id="U1444" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.784215784215784" /psig="0.998001998001998" /xcortree=568 /SigmaFactorBS="ttgacattgagacattatactccttctCATTTGAAaattagt ataaatATGGATATAATATAAACATTcactttgaagatctaatgtatgaaaggataca t" /listShort="ynzD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1750574..1750582 /Source="Nicolas_upshift_promotors" /id="U1445" /multdbtbs="SigA" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=535 /SigmaFactorBS="tatccatatttatactaattttcaaatgaGAAGGAGTAtaat gtctcaaTGTCAAATTAAATTATATAagttttttctgaaaatagaaatccttcaagtg a" /listShort="S663, ccdA, yneI, yneJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1750594..1750613) /Source="Nicolas_upshift_promotors" /id="U1446" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.492507492507492" /psig="0.999000999001" /xcortree=3128 /SigmaFactorBS="catttcatttttttaacactttcacttgaagGATTTCTAttt tcagaaaaaacTTATATAATTTAATTTGACAttgagacattatactccttctcatttg a" /listShort="ynzD, S661" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 1750594..1750612 /Source="Nicolas_upshift_promotors" /id="U1445" /multdbtbs="SigA" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=535 /SigmaFactorBS="tatccatatttatactaattttcaaatgaGAAGGAGTAtaat gtctcaaTGTCAAATTAAATTATATAagttttttctgaaaatagaaatccttcaagtg a" /listShort="S663, ccdA, yneI, yneJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1750605..1750713 /Source="Nicolas_S_feature" /locus_tag="new_1923125_1923233" /HighExp="T4.0H, T3.30H, T3.0H, S2, Lbstat, T5.0H, T2.30H, S4, T-1.40H, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH, SigA, SigA" /TUshortPSig="0.999, 1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S663" upshifts 1750605 /Source="Nicolas_upshifts" /id="U1445" /multdbtbs="SigA" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=535 /SigmaFactorBS="tatccatatttatactaattttcaaatgaGAAGGAGTAtaat gtctcaaTGTCAAATTAAATTATATAagttttttctgaaaatagaaatccttcaagtg a" /listShort="S663, ccdA, yneI, yneJ" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1750606) /Source="Nicolas_upshifts" /id="U1446" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.492507492507492" /psig="0.999000999001" /xcortree=3128 /SigmaFactorBS="catttcatttttttaacactttcacttgaagGATTTCTAttt tcagaaaaaacTTATATAATTTAATTTGACAttgagacattatactccttctcatttg a" /listShort="ynzD, S661" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1750628..1750635) /Source="Nicolas_upshift_promotors" /id="U1446" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.492507492507492" /psig="0.999000999001" /xcortree=3128 /SigmaFactorBS="catttcatttttttaacactttcacttgaagGATTTCTAttt tcagaaaaaacTTATATAATTTAATTTGACAttgagacattatactccttctcatttg a" /listShort="ynzD, S661" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1750714..1751421 /gene="ccdA" /locus_tag="BSU_17930" /old_locus_tag="BSU17930" /function="16.10: Respire" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15849754, 16771673, 16850406, 19682263" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16771673, 16850406, 19682263; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome c-type biogenesis protein CcdA; thiol-disulfide oxido-reductase" /protein_id="NP_389676.1" /db_xref="EnsemblGenomes-Gn:BSU17930" /db_xref="EnsemblGenomes-Tr:CAB13677" /db_xref="GOA:P45706" /db_xref="InterPro:IPR003834" /db_xref="SubtiList:BG11240" /db_xref="UniProtKB/Swiss-Prot:P45706" /translation="MGDVNYFLTFGAGFLSFISPCCLPLYPAFLSYITGVSMDDVKTE KLLLQKRSLFHTLCFLLGFSVIFIALGYGTSFIGSLFRDYHDAIRQIGALLIILFGFI TLGVFRPEAMMKERRIHFKHKPSGFLGSVLIGMAFAAGWTPCTGPILAAVITLAGTNP GSAVPYMMLYVLGFAVPFLLLSFFITKLKWIRKNQLFIMKAGGVLMIVIGVLLFFNWM SLIIILLSDLFGGFTGF*" /label="ccdA CDS" gene 1750714..1751421 /gene="ccdA" /locus_tag="BSU_17930" /old_locus_tag="BSU17930" /label="ccdA gene" promotor_-35 1751441..1751448 /Source="Nicolas_upshift_promotors" /id="U1447" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=2256 /SigmaFactorBS="ttactggtttttgacggtaaattactttcgtacTACTACTAa tccttttgttTTTGGTACAATAAGACTATTatctgtggaaatcgattgttggagggga a" /listShort="yneI, yneJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1751460..1751479 /Source="Nicolas_upshift_promotors" /id="U1447" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=2256 /SigmaFactorBS="ttactggtttttgacggtaaattactttcgtacTACTACTAa tccttttgttTTTGGTACAATAAGACTATTatctgtggaaatcgattgttggagggga a" /listShort="yneI, yneJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1751468 /Source="Nicolas_upshifts" /id="U1447" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=2256 /SigmaFactorBS="ttactggtttttgacggtaaattactttcgtacTACTACTAa tccttttgttTTTGGTACAATAAGACTATTatctgtggaaatcgattgttggagggga a" /listShort="yneI, yneJ" /GFF_Attribute="listLong" /label="upshifts" CDS 1751510..1751872 /gene="yneI" /locus_tag="BSU_17940" /old_locus_tag="BSU17940" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10781554; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative response regulator (CheY homolog)" /protein_id="NP_389677.1" /db_xref="EnsemblGenomes-Gn:BSU17940" /db_xref="EnsemblGenomes-Tr:CAB13678" /db_xref="GOA:P45709" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="SubtiList:BG11250" /db_xref="UniProtKB/Swiss-Prot:P45709" /translation="MTRVLVVDDAKFMRVKIREILEEANYIIAGEAADGEQAADLYKK LRPDLVTMDITMPVKNGIKALRDILTFDPKAKVIMCTAMRQQRIVTEAIELGAKDFIV KPFEETKVLEAVSRVMGH*" /label="yneI CDS" gene 1751510..1751872 /gene="yneI" /locus_tag="BSU_17940" /old_locus_tag="BSU17940" /label="yneI gene" promotor_-35 1751890..1751893 /Source="Nicolas_upshift_promotors" /id="U1448" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.637362637362637" /psig="0.993006993006993" /xcortree=3154 /SigmaFactorBS="ttatgggacattaaagtcatttcttttcaaaATGGttttttt tattgttTTGGAGTATAGTATATAGTAtcaacactccgagaaacaaaggaatgataag t" /listShort="yneJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1751908..1751927 /Source="Nicolas_upshift_promotors" /id="U1448" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.637362637362637" /psig="0.993006993006993" /xcortree=3154 /SigmaFactorBS="ttatgggacattaaagtcatttcttttcaaaATGGttttttt tattgttTTGGAGTATAGTATATAGTAtcaacactccgagaaacaaaggaatgataag t" /listShort="yneJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1751919 /Source="Nicolas_upshifts" /id="U1448" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.637362637362637" /psig="0.993006993006993" /xcortree=3154 /SigmaFactorBS="ttatgggacattaaagtcatttcttttcaaaATGGttttttt tattgttTTGGAGTATAGTATATAGTAtcaacactccgagaaacaaaggaatgataag t" /listShort="yneJ" /GFF_Attribute="listLong" /label="upshifts" CDS 1751951..1752442 /gene="yneJ" /locus_tag="BSU_17950" /old_locus_tag="BSU17950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10781554, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_389678.1" /db_xref="EnsemblGenomes-Gn:BSU17950" /db_xref="EnsemblGenomes-Tr:CAB13679" /db_xref="GOA:P45710" /db_xref="InterPro:IPR009916" /db_xref="InterPro:IPR031306" /db_xref="SubtiList:BG11251" /db_xref="UniProtKB/Swiss-Prot:P45710" /translation="MISMMIIVSSIIAVLMAVAVMVVRIKSSDKPVSPKKIILPPIFM STGALMFLFPVFWVTGAEFLEAFTLGVIFSIFLIKTSKFEIKNNEIYMKRSKAFVFIL VGLLVIRIVMKSILSTSIDYGALSGMFWILAFGMIVPWRIAMYLSYRKLHNELQSSNI QMN*" /label="yneJ CDS" gene 1751951..1752442 /gene="yneJ" /locus_tag="BSU_17950" /old_locus_tag="BSU17950" /label="yneJ gene" downshifts 1752438 /Source="Nicolas_upshifts" /id="D978" /incds=0 /nref=110 /ntot=273 /MaxReadThrough="1.09905" /MaxDrop="5.9692" /score="16.4219082" /energy="-9.7" /TU="NA" /idTUdmin="U1445" /TUdmin=2 /isTUend="TRUE" /label="downshifts" CDS complement(1752473..1752901) /gene="yneK" /locus_tag="BSU_17960" /old_locus_tag="BSU17960" /experiment="publication(s) with functional evidences, PMID:23060960" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23060960; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor interacting with DynA" /protein_id="NP_389679.1" /db_xref="EnsemblGenomes-Gn:BSU17960" /db_xref="EnsemblGenomes-Tr:CAB13680" /db_xref="InterPro:IPR020203" /db_xref="SubtiList:BG11252" /db_xref="UniProtKB/Swiss-Prot:P45711" /translation="MLEGWFLWFILFWVIMMVVLLSIGGFFMFRKFLKRLPKEDGRSE LDWQDYYIENSRHLWNDENKQFLDELTAPVPELFRDAAKAKIAGKIGELALKEKVAKI DQQLMIKGYILATPKRDHTFLKRHLRDKKIDLEPYQTLLK*" /label="yneK CDS" gene complement(1752473..1752901) /gene="yneK" /locus_tag="BSU_17960" /old_locus_tag="BSU17960" /label="yneK gene" downshifts complement(1752490) /Source="Nicolas_upshifts" /id="D979" /incds=0 /nref=188 /ntot=245 /MaxReadThrough="1.60911" /MaxDrop="5.09033" /score="10.710816" /energy="-9.7" /TU="NA" /idTUdmin="U1449" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1752919..1752938) /Source="Nicolas_upshift_promotors" /id="U1449" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.796203796203796" /psig="0.999000999001" /xcortree=3159 /SigmaFactorBS="gacgtctatcacttttttctattctttttttaCTGTGTTCtt ctaatctctctTCGTATACAATATGGTTAGAataagggggaatgattgatgctggaag g" /listShort="yneK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1752931) /Source="Nicolas_upshifts" /id="U1449" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.796203796203796" /psig="0.999000999001" /xcortree=3159 /SigmaFactorBS="gacgtctatcacttttttctattctttttttaCTGTGTTCtt ctaatctctctTCGTATACAATATGGTTAGAataagggggaatgattgatgctggaag g" /listShort="yneK" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1752933..1753018) /Source="Nicolas_S_feature" /locus_tag="new_1925453_1925538_c" /HighExp="S8, S6, S7, LBGstat, C30, dia15, S0, Cold, T1.0H, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.958, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S664" promotor_-35 complement(1752952..1752959) /Source="Nicolas_upshift_promotors" /id="U1449" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.796203796203796" /psig="0.999000999001" /xcortree=3159 /SigmaFactorBS="gacgtctatcacttttttctattctttttttaCTGTGTTCtt ctaatctctctTCGTATACAATATGGTTAGAataagggggaatgattgatgctggaag g" /listShort="yneK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1752989..1752998 /Source="Nicolas_upshift_promotors" /id="U1450" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1415 /SigmaFactorBS="agaagaacacagtaaaaaaagaatagaaaaaagtgatagacG TCTAGTCAAaagagatagtagATCATATTCTATTGTATAGTgaatctgctatttggcc a" /listShort="S665" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1753008..1753117 /Source="Nicolas_S_feature" /locus_tag="new_1925528_1925637" /HighExp="S8, BT, B36, S7, G/S, Pyr, B60, S6, Glucon, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S665" upshifts 1753008 /Source="Nicolas_upshifts" /id="U1450" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1415 /SigmaFactorBS="agaagaacacagtaaaaaaagaatagaaaaaagtgatagacG TCTAGTCAAaagagatagtagATCATATTCTATTGTATAGTgaatctgctatttggcc a" /listShort="S665" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1753011..1753030 /Source="Nicolas_upshift_promotors" /id="U1450" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1415 /SigmaFactorBS="agaagaacacagtaaaaaaagaatagaaaaaagtgatagacG TCTAGTCAAaagagatagtagATCATATTCTATTGTATAGTgaatctgctatttggcc a" /listShort="S665" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1753013..1753032) /Source="Nicolas_upshift_promotors" /id="U1451" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.53946053946054" /psig="0.958041958041958" /xcortree=1633 /SigmaFactorBS="atcgtcaaataccctctagtgactctccCATGgccaaatagc agatTCACTATACAATAGAATATGatctactatctcttttgactagacgtctatcact t" /listShort="S664, yneK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1753018) /Source="Nicolas_upshifts" /id="U1451" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.53946053946054" /psig="0.958041958041958" /xcortree=1633 /SigmaFactorBS="atcgtcaaataccctctagtgactctccCATGgccaaatagc agatTCACTATACAATAGAATATGatctactatctcttttgactagacgtctatcact t" /listShort="S664, yneK" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1753020..1753103) /Source="Nicolas_S_feature" /locus_tag="new_1925540_1925623_c" /HighExp="S8, S6, S7, C30, BT, S5, Pyr, Glucon, BC, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S666" promotor_-35 complement(1753047..1753050) /Source="Nicolas_upshift_promotors" /id="U1451" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.53946053946054" /psig="0.958041958041958" /xcortree=1633 /SigmaFactorBS="atcgtcaaataccctctagtgactctccCATGgccaaatagc agatTCACTATACAATAGAATATGatctactatctcttttgactagacgtctatcact t" /listShort="S664, yneK" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1753074 /Source="Nicolas_upshifts" /id="D980" /incds=0 /nref=9 /ntot=30 /MaxReadThrough="3.76639" /MaxDrop="5.34013" /score="5.70696998" /energy="-12.7" /TU="U1450" /idTUdmin="U1450" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" CDS complement(1753135..1753527) /gene="cotM" /locus_tag="BSU_17970" /old_locus_tag="BSU17970" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9068633, 11150673" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9068633, 11150673; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="spore coat protein (outer)" /protein_id="NP_389680.1" /db_xref="EnsemblGenomes-Gn:BSU17970" /db_xref="EnsemblGenomes-Tr:CAB13681" /db_xref="GOA:Q45058" /db_xref="InterPro:IPR008978" /db_xref="SubtiList:BG11822" /db_xref="UniProtKB/Swiss-Prot:Q45058" /translation="MWRNASMNHSKRNDANDFDSMDEWLRQFFEDPFAWYDETLPIDL YETSQQYIIEADLTFLQPTQVTVTLSGCEFILTVKSSGQTFEKQMMLPFYFNDKNIQV ECENQILTVAVNKETEDGSSFSLQFPLS*" /label="cotM CDS" gene complement(1753135..1753527) /gene="cotM" /locus_tag="BSU_17970" /old_locus_tag="BSU17970" /label="cotM gene" downshifts complement(1753148) /Source="Nicolas_upshifts" /id="D981" /incds=0 /nref=20 /ntot=92 /MaxReadThrough="4.44864" /MaxDrop="4.9615" /score="11.5991121" /energy="-12.7" /TU="U1454" /idTUdmin="U1456" /TUdmin=486 /isTUend="FALSE" /label="downshifts" promotor_-35 1753370..1753375 /Source="Nicolas_upshift_promotors" /id="U1452" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=439 /SigmaFactorBS="cttgtgtaggctgtaaaaaagtcagatccgcttctATAATAt actgctgacttgttTCATATAAATCAATAGGCAatgtttcgtcgtaccaggcgaaggg g" /listShort="S667" /listLong="S668, citB, S669, yneN" /label="promotor_-35" promotor_-10 1753391..1753409 /Source="Nicolas_upshift_promotors" /id="U1452" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=439 /SigmaFactorBS="cttgtgtaggctgtaaaaaagtcagatccgcttctATAATAt actgctgacttgttTCATATAAATCAATAGGCAatgtttcgtcgtaccaggcgaaggg g" /listShort="S667" /listLong="S668, citB, S669, yneN" /label="promotor_-10" upshifts 1753395 /Source="Nicolas_upshifts" /id="U1452" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=439 /SigmaFactorBS="cttgtgtaggctgtaaaaaagtcagatccgcttctATAATAt actgctgacttgttTCATATAAATCAATAGGCAatgtttcgtcgtaccaggcgaaggg g" /listShort="S667" /listLong="S668, citB, S669, yneN" /label="upshifts" promotor_-35 1753505..1753509 /Source="Nicolas_upshift_promotors" /id="U1453" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=1243 /SigmaFactorBS="aatcattcgcatcgttgcgttttgaatggTTCATggaagcat tCCTCCACATATCAACcttgctttacatcatatgcggtggattataaatgggtgaacg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1753519..1753533 /Source="Nicolas_upshift_promotors" /id="U1453" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=1243 /SigmaFactorBS="aatcattcgcatcgttgcgttttgaatggTTCATggaagcat tCCTCCACATATCAACcttgctttacatcatatgcggtggattataaatgggtgaacg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1753534..1753553) /Source="Nicolas_upshift_promotors" /id="U1454" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1290 /SigmaFactorBS="aagaaaagcagaccttagtgtctgtttttttatGCGTTCACC CatttataatccacCGCATATGATGTAAAGCAAGgttgatatgtggaggaatgcttcc a" /listShort="cotM, S666, S664, yneK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1753536 /Source="Nicolas_upshifts" /id="U1453" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=1243 /SigmaFactorBS="aatcattcgcatcgttgcgttttgaatggTTCATggaagcat tCCTCCACATATCAACcttgctttacatcatatgcggtggattataaatgggtgaacg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1753549) /Source="Nicolas_upshifts" /id="U1454" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1290 /SigmaFactorBS="aagaaaagcagaccttagtgtctgtttttttatGCGTTCACC CatttataatccacCGCATATGATGTAAAGCAAGgttgatatgtggaggaatgcttcc a" /listShort="cotM, S666, S664, yneK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1753567..1753576) /Source="Nicolas_upshift_promotors" /id="U1454" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1290 /SigmaFactorBS="aagaaaagcagaccttagtgtctgtttttttatGCGTTCACC CatttataatccacCGCATATGATGTAAAGCAAGgttgatatgtggaggaatgcttcc a" /listShort="cotM, S666, S664, yneK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1753608..1753754) /gene="sspP" /locus_tag="BSU_17980" /old_locus_tag="BSU17980" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10806362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10806362; Product type f: factor" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="NP_389681.1" /db_xref="EnsemblGenomes-Gn:BSU17980" /db_xref="EnsemblGenomes-Tr:CAB13682" /db_xref="GOA:P71032" /db_xref="InterPro:IPR012614" /db_xref="SubtiList:BG11921" /db_xref="UniProtKB/Swiss-Prot:P71032" /translation="MTNKNTSKDMHKNAPKGHNPGQPEPLSGSKKVKNRNHTRQKHNS SHDM*" /label="sspP CDS" gene complement(1753608..1753754) /gene="sspP" /locus_tag="BSU_17980" /old_locus_tag="BSU17980" /label="sspP gene" downshifts complement(1753629) /Source="Nicolas_upshifts" /id="D982" /incds=0 /nref=42 /ntot=61 /MaxReadThrough="1.80349" /MaxDrop="6.88836" /score="0.778507843" /energy="-4.3" /TU="NA" /idTUdmin="U1456" /TUdmin=5 /isTUend="TRUE" /label="downshifts" CDS complement(1753786..1753932) /gene="sspO" /locus_tag="BSU_17990" /old_locus_tag="BSU17990" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9852018, 10806362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9852018, 10806362; Product type s: structure" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="NP_389682.1" /db_xref="EnsemblGenomes-Gn:BSU17990" /db_xref="EnsemblGenomes-Tr:CAB13683" /db_xref="GOA:P71031" /db_xref="InterPro:IPR012613" /db_xref="SubtiList:BG11920" /db_xref="UniProtKB/Swiss-Prot:P71031" /translation="MVKRKANHVINGMNDAKSQGKGAGYIENDQLVLTEAERQNNKKR KTNQ*" /label="sspO CDS" gene complement(1753786..1753932) /gene="sspO" /locus_tag="BSU_17990" /old_locus_tag="BSU17990" /label="sspO gene" S_feature 1753932..1754065 /Source="Nicolas_S_feature" /locus_tag="new_1926452_1926585" /HighExp="S8, S7, S3, S6, LoTm, S4, S5, BT, Pyr, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S667" upshifts 1753932 /Source="Nicolas_upshifts" /id="U1455" /multdbtbs="-" /comp="M19" /sig="Sig-" /pcomp="0.228771228771229" /psig="0.312687312687313" /xcortree=1215 /SigmaFactorBS="tgccttggctttttgcgtcattcattccgttaatgacgtgat tcgcttttcttttgaccatcattatcaccTCAatcataatatggcttcttttattgtg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 1753943..1753945 /Source="Nicolas_upshift_promotors" /id="U1455" /multdbtbs="-" /comp="M19" /sig="Sig-" /pcomp="0.228771228771229" /psig="0.312687312687313" /xcortree=1215 /SigmaFactorBS="tgccttggctttttgcgtcattcattccgttaatgacgtgat tcgcttttcttttgaccatcattatcaccTCAatcataatatggcttcttttattgtg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(1753948..1753959) /Source="Nicolas_upshift_promotors" /id="U1456" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=837 /SigmaFactorBS="ttatgagaaaaatgtaccggtaatttttactgtttacgctct CTCATATaacacaataaaagaAGCCATATTATGattgaggtgataatgatggtcaaaa g" /listShort="sspO, sspP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1753962) /Source="Nicolas_upshifts" /id="U1456" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=837 /SigmaFactorBS="ttatgagaaaaatgtaccggtaatttttactgtttacgctct CTCATATaacacaataaaagaAGCCATATTATGattgaggtgataatgatggtcaaaa g" /listShort="sspO, sspP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1753974..1753980) /Source="Nicolas_upshift_promotors" /id="U1456" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=837 /SigmaFactorBS="ttatgagaaaaatgtaccggtaatttttactgtttacgctct CTCATATaacacaataaaagaAGCCATATTATGattgaggtgataatgatggtcaaaa g" /listShort="sspO, sspP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1754055..1754062 /Source="Nicolas_upshift_promotors" /id="U1457" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.956043956043956" /psig=1 /xcortree=2774 /SigmaFactorBS="tacatttttctcataagtcgaacttattgtatttaataaaaa cattgaTATTTACTtatgtatgattttgTTTTAATATGAAATTGTGAGaaaattgtga t" /listShort="S668, citB, S669, yneN, ynzL, sspN, tlp" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1754067..1754159 /Source="Nicolas_S_feature" /locus_tag="new_1926587_1926679" /HighExp="B60, M40t90, T0.0H, HiOs, T4.0H, T5.0H, T2.30H, M0t90, Sw, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig="0.994" /label="S668" upshifts 1754067 /Source="Nicolas_upshifts" /id="U1457" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.956043956043956" /psig=1 /xcortree=2774 /SigmaFactorBS="tacatttttctcataagtcgaacttattgtatttaataaaaa cattgaTATTTACTtatgtatgattttgTTTTAATATGAAATTGTGAGaaaattgtga t" /listShort="S668, citB, S669, yneN, ynzL, sspN, tlp" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1754077..1754096 /Source="Nicolas_upshift_promotors" /id="U1457" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.956043956043956" /psig=1 /xcortree=2774 /SigmaFactorBS="tacatttttctcataagtcgaacttattgtatttaataaaaa cattgaTATTTACTtatgtatgattttgTTTTAATATGAAATTGTGAGaaaattgtga t" /listShort="S668, citB, S669, yneN, ynzL, sspN, tlp" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(1754118) /Source="Nicolas_upshifts" /id="D983" /incds=0 /nref=1 /ntot=67 /MaxReadThrough="2.77282" /MaxDrop="4.02811" /score="0.778507843" /energy="-4.3" /TU="NA" /idTUdmin="U1458" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 1754160..1756889 /gene="citB" /locus_tag="BSU_18000" /old_locus_tag="BSU18000" /EC_number="4.2.1.3" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9642180, 10468622, 10656796, 14636591, 16395550, 16923907, 22720735, 23354745" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9642180, 10468622, 10656796, 14636591, 16395550, 16923907, 22720735, 23354745; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aconitate hydratase (bifunctional aconitase)" /protein_id="NP_389683.1" /db_xref="EnsemblGenomes-Gn:BSU18000" /db_xref="EnsemblGenomes-Tr:CAB13684" /db_xref="GOA:P09339" /db_xref="InterPro:IPR000573" /db_xref="InterPro:IPR001030" /db_xref="InterPro:IPR006249" /db_xref="InterPro:IPR015928" /db_xref="InterPro:IPR015931" /db_xref="InterPro:IPR015932" /db_xref="InterPro:IPR018136" /db_xref="InterPro:IPR036008" /db_xref="SubtiList:BG10478" /db_xref="UniProtKB/Swiss-Prot:P09339" /translation="MANEQKTAAKDVFQARKTFTTNGKTYHYYSLKALEDSGIGKVSK LPYSIKVLLESVLRQVDGFVIKKEHVENLAKWGTAELKDIDVPFKPSRVILQDFTGVP AVVDLASLRKAMAAVGGDPDKINPEIPVDLVIDHSVQVDKAGTEDALAVNMDLEFERN AERYKFLSWAKKAFNNYQAVPPATGIVHQVNLEFLASVVHAIEEDGELVTYPDTLVGT DSHTTMINGIGVLGWGVGGIEAEAGMLGQPSYFPVPEVIGAKLVGKLPNGTTATDLAL KVTQVLREKGVVGKFVEFFGPGIAELPLADRATIANMAPEYGATCGFFPVDEEALNYL RLTGRDPEHIDVVEAYCRSNGLFYTPDAEDPQFTDVVEIDLSQIEANLSGPKRPQDLI PLSAMQETFKKQLVSPAGNQGFGLNAEEENKEIKFKLLNGEETVMKTGAIAIAAITSC TNTSNPYVLIGAGLVAKKAVELGLKVPNYVKTSLAPGSKVVTGYLVNSGLLPYMKELG FNLVGYGCTTCIGNSGPLSPEIEEAVAKNDLLITSVLSGNRNFEGRIHPLVKGNYLAS PPLVVAYALAGTVNINLKTDPIGVGKDGQNVYFNDIWPSMDEINALVKQTVTPELFRK EYETVFDDNKRWNEIETTDEALYKWDNDSTYIQNPPFFEEMSVEPGKVEPLKGLRVVG KFGDSVTTDHISPAGAIGKDTPAGKYLQEKGVSPRDFNSYGSRRGNHEVMMRGTFANI RIKNQIAPGTEGGFTTYWPTGEVTSIYDACMKYKEDKTGLVVLAGKDYGMGSSRDWAA KGTNLLGIRTVIAESFERIHRSNLVFMGVLPLQFKQGENADTLGLTGKEVIEVDVDET VRPRDLVTVRAINEDGNVTTFEAVVRFDSEVEIDYYRHGGILQMVLREKMKQS*" /label="citB CDS" gene 1754160..1756889 /gene="citB" /locus_tag="BSU_18000" /old_locus_tag="BSU18000" /label="citB gene" misc_feature complement(1754180..1754184) /Source="Nicolas_upshift_promotors" /id="U1458" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95104895104895" /psig="0.001998001998002" /xcortree=88 /SigmaFactorBS="agtaatgatatgttttcccatttgtagtaaacgtttttctcg cttggaaaacgtcttttgCTGCAgttttttgctcgtttgccattctccaaaatccccc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1754184) /Source="Nicolas_upshifts" /id="U1458" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95104895104895" /psig="0.001998001998002" /xcortree=88 /SigmaFactorBS="agtaatgatatgttttcccatttgtagtaaacgtttttctcg cttggaaaacgtcttttgCTGCAgttttttgctcgtttgccattctccaaaatccccc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature 1756890..1756960 /Source="Nicolas_S_feature" /locus_tag="new_1929410_1929480" /HighExp="M9-stat, B60, M40t90, Glucon, M0t90, MG-0.2, Mal, T2.30H, MG-0.1, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig="0.994" /label="S669" CDS 1756961..1757473 /gene="yneN" /locus_tag="BSU_18010" /old_locus_tag="BSU18010" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15342593; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane-bound proteins with a thioredoxin-like domain" /protein_id="NP_389684.1" /db_xref="EnsemblGenomes-Gn:BSU18010" /db_xref="EnsemblGenomes-Tr:CAB13685" /db_xref="GOA:O31820" /db_xref="InterPro:IPR000866" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG13451" /db_xref="UniProtKB/Swiss-Prot:O31820" /translation="MLKKWLAGILLIMLVGYTGWNLYQTYSKKEVGIQEGQQAPDFSL KTLSGEKSSLQDAKGKKVLLNFWATWCKPCRQEMPAMEKLQKEYADKLAVVAVNFTSA EKSEKQVRAFADTYDLTFPILIDKKGINADYNVMSYPTTYILDEKGVIQDIHVGTMTK KEMEQKLDLD*" /label="yneN CDS" gene 1756961..1757473 /gene="yneN" /locus_tag="BSU_18010" /old_locus_tag="BSU18010" /label="yneN gene" downshifts 1757430 /Source="Nicolas_upshifts" /id="D984" /incds=0 /nref=115 /ntot=218 /MaxReadThrough="3.76369" /MaxDrop="5.09954" /score="13.5401842" /energy="-6.9" /TU="U1457" /idTUdmin="U1457" /TUdmin="-726" /isTUend="FALSE" /label="downshifts" promotor_-35 1757499..1757505 /Source="Nicolas_upshift_promotors" /id="U1459" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.715284715284715" /psig="0.715284715284715" /xcortree=1010 /SigmaFactorBS="actggatcttgattagattcagttttttttatactcaaataT GCTTACaagttttcagaattGGAAAAAATAAAagaatatgcggaggtgagaagcgtga a" /listShort="ynzL, sspN, tlp" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1757518 /Source="Nicolas_upshifts" /id="U1459" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.715284715284715" /psig="0.715284715284715" /xcortree=1010 /SigmaFactorBS="actggatcttgattagattcagttttttttatactcaaataT GCTTACaagttttcagaattGGAAAAAATAAAagaatatgcggaggtgagaagcgtga a" /listShort="ynzL, sspN, tlp" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1757520..1757531 /Source="Nicolas_upshift_promotors" /id="U1459" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.715284715284715" /psig="0.715284715284715" /xcortree=1010 /SigmaFactorBS="actggatcttgattagattcagttttttttatactcaaataT GCTTACaagttttcagaattGGAAAAAATAAAagaatatgcggaggtgagaagcgtga a" /listShort="ynzL, sspN, tlp" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1757554..1757679 /gene="ynzL" /locus_tag="BSU_18019" /old_locus_tag="BSU18019" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097732.1" /db_xref="EnsemblGenomes-Gn:BSU18019" /db_xref="EnsemblGenomes-Tr:CAX52626" /db_xref="InterPro:IPR025004" /db_xref="UniProtKB/Swiss-Prot:C0H418" /translation="MKKMRKRSFHELVMENKKELMTNTEYLNQLEEKLEQRFKQK*" /label="ynzL CDS" gene 1757554..1757679 /gene="ynzL" /locus_tag="BSU_18019" /old_locus_tag="BSU18019" /label="ynzL gene" downshifts complement(1757572) /Source="Nicolas_upshifts" /id="D985" /incds=0 /nref=1 /ntot=8 /MaxReadThrough="3.12259" /MaxDrop="3.48183" /score="-0.0160782027" /energy="-13.9" /TU="NA" /idTUdmin="U1462" /TUdmin=1298 /isTUend="FALSE" /label="downshifts" promotor_-35 1757693..1757699 /Source="Nicolas_upshift_promotors" /id="U1460" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.844155844155844" /psig="0.844155844155844" /xcortree=843 /SigmaFactorBS="gaacagcgatttaagcaaaaataacctttaatttgtaTTCAT GTttacccctccttttGAGAAACCTATCtgttgaggagggataaacatgggaaacaac a" /listShort="sspN, tlp" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1757714..1757725 /Source="Nicolas_upshift_promotors" /id="U1460" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.844155844155844" /psig="0.844155844155844" /xcortree=843 /SigmaFactorBS="gaacagcgatttaagcaaaaataacctttaatttgtaTTCAT GTttacccctccttttGAGAAACCTATCtgttgaggagggataaacatgggaaacaac a" /listShort="sspN, tlp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1757716 /Source="Nicolas_upshifts" /id="U1460" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.844155844155844" /psig="0.844155844155844" /xcortree=843 /SigmaFactorBS="gaacagcgatttaagcaaaaataacctttaatttgtaTTCAT GTttacccctccttttGAGAAACCTATCtgttgaggagggataaacatgggaaacaac a" /listShort="sspN, tlp" /GFF_Attribute="listLong" /label="upshifts" CDS 1757744..1757890 /gene="sspN" /locus_tag="BSU_18020" /old_locus_tag="BSU18020" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10333516" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10333516; Product type f: factor" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="YP_054579.2" /db_xref="EnsemblGenomes-Gn:BSU18020" /db_xref="EnsemblGenomes-Tr:CAE01455" /db_xref="GOA:Q7WY69" /db_xref="InterPro:IPR012612" /db_xref="SubtiList:BG14179" /db_xref="UniProtKB/Swiss-Prot:Q7WY69" /translation="MGNNKKNGQPQYAPSHLGTKPVKYKANKGEKMHDTSGQRPIIMQ TKGE*" /label="sspN CDS" gene 1757744..1757890 /gene="sspN" /locus_tag="BSU_18020" /old_locus_tag="BSU18020" /label="sspN gene" CDS 1757927..1758178 /gene="sspT" /locus_tag="BSU_18030" /old_locus_tag="BSU18030" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10333516" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10333516; Product type f: factor" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein (thioredoxin-like protein)" /protein_id="NP_389685.1" /db_xref="EnsemblGenomes-Gn:BSU18030" /db_xref="EnsemblGenomes-Tr:CAB13686" /db_xref="GOA:Q45060" /db_xref="InterPro:IPR017524" /db_xref="SubtiList:BG11806" /db_xref="UniProtKB/Swiss-Prot:Q45060" /translation="MTKNQNQYQQPNPDDRSDNVEKLQDMVQNTIENIEEAEASMEFA SGEDKQRIKEKNARREQSIEAFRNEIQDESAARQNGYRS*" /label="sspT CDS" gene 1757927..1758178 /gene="sspT" /locus_tag="BSU_18030" /old_locus_tag="BSU18030" /label="sspT gene" downshifts 1758156 /Source="Nicolas_upshifts" /id="D986" /incds=0 /nref=41 /ntot=49 /MaxReadThrough="2.07653" /MaxDrop="7.06685" /score="32.1193211" /energy="-7" /TU="NA" /idTUdmin="U1457" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1758199..1758204 /Source="Nicolas_upshift_promotors" /id="U1461" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.68031968031968" /psig=1 /xcortree=2003 /SigmaFactorBS="acggataccgttcttaaaaaaccagggaaacctggttTTTTT CtttctgatttgatTATGGTAAAATGGGGCTAAAttgacgttaagggagcagagtaat c" /listShort="S670, yneP, yneQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1758218..1758237 /Source="Nicolas_upshift_promotors" /id="U1461" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.68031968031968" /psig=1 /xcortree=2003 /SigmaFactorBS="acggataccgttcttaaaaaaccagggaaacctggttTTTTT CtttctgatttgatTATGGTAAAATGGGGCTAAAttgacgttaagggagcagagtaat c" /listShort="S670, yneP, yneQ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1758222..1758313 /Source="Nicolas_S_feature" /locus_tag="new_1930742_1930833" /HighExp="Etha, dia5, dia15, Diami, H2O2, G180, Salt, G150, BMM, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S670" upshifts 1758222 /Source="Nicolas_upshifts" /id="U1461" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.68031968031968" /psig=1 /xcortree=2003 /SigmaFactorBS="acggataccgttcttaaaaaaccagggaaacctggttTTTTT CtttctgatttgatTATGGTAAAATGGGGCTAAAttgacgttaagggagcagagtaat c" /listShort="S670, yneP, yneQ" /GFF_Attribute="listLong" /label="upshifts" CDS 1758314..1758679 /gene="yneP" /locus_tag="BSU_18040" /old_locus_tag="BSU18040" /EC_number="3.1.2.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11959124, 11994151, 16294310, 18338382; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acyl-CoA thioesterase" /protein_id="YP_054580.1" /db_xref="EnsemblGenomes-Gn:BSU18040" /db_xref="EnsemblGenomes-Tr:CAB13687" /db_xref="GOA:Q45061" /db_xref="InterPro:IPR006683" /db_xref="InterPro:IPR006684" /db_xref="InterPro:IPR029069" /db_xref="SubtiList:BG11823" /db_xref="UniProtKB/Swiss-Prot:Q45061" /translation="MGIVYHANYLVWMEVGRTALIKDLGFLYSDMEKKGVLSPVVDIN ISYKKPLHYGETAVVHTWIEDYNGFKTVYGYHIYNPAGELSIKATSSHICVDKESFKP IQFRKAFPDWHTAYEKAKK*" /label="yneP CDS" gene 1758314..1758679 /gene="yneP" /locus_tag="BSU_18040" /old_locus_tag="BSU18040" /label="yneP gene" CDS 1758695..1758994 /gene="yneQ" /locus_tag="BSU_18050" /old_locus_tag="BSU18050" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389687.1" /db_xref="EnsemblGenomes-Gn:BSU18050" /db_xref="EnsemblGenomes-Tr:CAB13688" /db_xref="SubtiList:BG11824" /db_xref="UniProtKB/Swiss-Prot:Q45062" /translation="MAFGVKREELNRWKQAVKRGEIAFLTHYWLDDRFPEAKTVTKAG CADIDKLVQWGAAYGLKKEWIHKKSEFPHFDLLGETQKYILEQENLTDHLIRFHL*" /label="yneQ CDS" gene 1758695..1758994 /gene="yneQ" /locus_tag="BSU_18050" /old_locus_tag="BSU18050" /label="yneQ gene" downshifts 1758970 /Source="Nicolas_upshifts" /id="D987" /incds=0 /nref=55 /ntot=217 /MaxReadThrough="3.04989" /MaxDrop="5.5978" /score="-4.41102273" /energy="-6" /TU="NA" /idTUdmin="U1461" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1759025..1759312) /gene="yneR" /locus_tag="BSU_18060" /old_locus_tag="BSU18060" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22333191, 23176286" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389688.1" /db_xref="EnsemblGenomes-Gn:BSU18060" /db_xref="EnsemblGenomes-Tr:CAB13689" /db_xref="InterPro:IPR000361" /db_xref="InterPro:IPR008326" /db_xref="InterPro:IPR035903" /db_xref="SubtiList:BG11825" /db_xref="UniProtKB/Swiss-Prot:Q45063" /translation="MNMTINEDALNWYKEELDLESGDQVRFFVRYGGCSNVQKGFSLG VAKDAPQEAGVTAEADGITFFIEESDLWYFDNHDLLVSYSEDADEPVFEYQ*" /label="yneR CDS" gene complement(1759025..1759312) /gene="yneR" /locus_tag="BSU_18060" /old_locus_tag="BSU18060" /label="yneR gene" downshifts complement(1759046) /Source="Nicolas_upshifts" /id="D988" /incds=0 /nref=216 /ntot=260 /MaxReadThrough="3.77766" /MaxDrop="7.20006" /score="-5.4451498" /energy="-6" /TU="U1462,U1463" /idTUdmin="U1463" /TUdmin="-154" /isTUend="FALSE" /label="downshifts" downshifts complement(1759112) /Source="Nicolas_upshifts" /id="D989" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="7.5674" /MaxDrop="3.11178" /score="-5.4451498" /energy="-6" /TU="U1462,U1463" /idTUdmin="U1463" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1759342..1759361) /Source="Nicolas_upshift_promotors" /id="U1462" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.755244755244755" /psig="0.999000999001" /xcortree=2062 /SigmaFactorBS="gtaaaatggttataagcttaaaaaacttctCTTTTGACacag aatagcctaatACGTTTATAATAGAGAAAATtcaaatgaagaacaaaggggtgttctg t" /listShort="yneR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1759354) /Source="Nicolas_upshifts" /id="U1462" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.755244755244755" /psig="0.999000999001" /xcortree=2062 /SigmaFactorBS="gtaaaatggttataagcttaaaaaacttctCTTTTGACacag aatagcctaatACGTTTATAATAGAGAAAATtcaaatgaagaacaaaggggtgttctg t" /listShort="yneR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1759377..1759384) /Source="Nicolas_upshift_promotors" /id="U1462" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.755244755244755" /psig="0.999000999001" /xcortree=2062 /SigmaFactorBS="gtaaaatggttataagcttaaaaaacttctCTTTTGACacag aatagcctaatACGTTTATAATAGAGAAAATtcaaatgaagaacaaaggggtgttctg t" /listShort="yneR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1759400..1759981) /gene="plsY" /locus_tag="BSU_18070" /old_locus_tag="BSU18070" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15849754, 16850406, 16949372, 17005971, 17308305, 17557823, 17645809, 19282621, 26644587" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15849754, 16850406, 16949372, 17005971, 17308305, 17557823, 17645809, 19282621, 26644587; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acylphosphate:glycerol-3-phosphate O-acyltransferase" /protein_id="NP_389689.1" /db_xref="EnsemblGenomes-Gn:BSU18070" /db_xref="EnsemblGenomes-Tr:CAB13690" /db_xref="GOA:Q45064" /db_xref="InterPro:IPR003811" /db_xref="SubtiList:BG11826" /db_xref="UniProtKB/Swiss-Prot:Q45064" /translation="MLIALLIILAYLIGSIPSGLIVGKLAKGIDIREHGSGNLGATNA FRTLGVKAGSVVIAGDILKGTLATALPFLMHVDIHPLLAGVFAVLGHVFPIFAKFKGG KAVATSGGVLLFYAPLLFITMVAVFFIFLYLTKFVSLSSMLTGIYTVIYSFFVHDTYL LIVVTLLTIFVIYRHRANIKRIINKTEPKVKWL*" /label="plsY CDS" gene complement(1759400..1759981) /gene="plsY" /locus_tag="BSU_18070" /old_locus_tag="BSU18070" /label="plsY gene" S_feature 1759982..1760112 /Source="Nicolas_S_feature" /locus_tag="new_1932502_1932632" /HighExp="C30, S8, S7, S5, S6, S4, BC, S3, T4.0H, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S671" misc_feature complement(1760007..1760026) /Source="Nicolas_upshift_promotors" /id="U1463" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2140 /SigmaFactorBS="tttgatttgatttgtaagcaaactttacaaaaaaacttatca tcagatcatgacatctCATGTTAAAATAAAAAGAAGggaatttgaaaaaggagaaatg t" /listShort="plsY, yneR" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1760024) /Source="Nicolas_upshifts" /id="U1463" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2140 /SigmaFactorBS="tttgatttgatttgtaagcaaactttacaaaaaaacttatca tcagatcatgacatctCATGTTAAAATAAAAAGAAGggaatttgaaaaaggagaaatg t" /listShort="plsY, yneR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1760097..1760100 /Source="Nicolas_upshift_promotors" /id="U1464" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.52047952047952" /psig="0.998001998001998" /xcortree=3133 /SigmaFactorBS="tttgtaaagtttgcttacaaatcaaatcaaacatgcatcata tTTTGatttctcctgttttgATCGTGTAAAATAAGTGAAAaaggagtgacacacgatg c" /listShort="yneT, S672, parE, parC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1760114 /Source="Nicolas_upshifts" /id="U1464" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.52047952047952" /psig="0.998001998001998" /xcortree=3133 /SigmaFactorBS="tttgtaaagtttgcttacaaatcaaatcaaacatgcatcata tTTTGatttctcctgttttgATCGTGTAAAATAAGTGAAAaaggagtgacacacgatg c" /listShort="yneT, S672, parE, parC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1760116..1760135 /Source="Nicolas_upshift_promotors" /id="U1464" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.52047952047952" /psig="0.998001998001998" /xcortree=3133 /SigmaFactorBS="tttgtaaagtttgcttacaaatcaaatcaaacatgcatcata tTTTGatttctcctgttttgATCGTGTAAAATAAGTGAAAaaggagtgacacacgatg c" /listShort="yneT, S672, parE, parC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1760151..1760558 /gene="yneT" /locus_tag="BSU_18080" /old_locus_tag="BSU18080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22938038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyl-CoA-binding protein" /protein_id="NP_389690.1" /db_xref="EnsemblGenomes-Gn:BSU18080" /db_xref="EnsemblGenomes-Tr:CAB13691" /db_xref="GOA:Q45065" /db_xref="InterPro:IPR003781" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11827" /db_xref="UniProtKB/Swiss-Prot:Q45065" /translation="MQNPSKAEIKEILQRSKRIAVVGLSDRPDRTSHMVSKAMQDAGY EIIPVNPTIDEALGVKAVSSLKEIDGPIDIVNVFRRSEQLPGVAEEFLETDAPVFWAQ QGLVNEEAYQMLKEKGRTVIMDLCIKVAHAVTK*" /label="yneT CDS" gene 1760151..1760558 /gene="yneT" /locus_tag="BSU_18080" /old_locus_tag="BSU18080" /label="yneT gene" downshifts 1760554 /Source="Nicolas_upshifts" /id="D990" /incds=0 /nref=63 /ntot=221 /MaxReadThrough="4.35976" /MaxDrop="5.49229" /score="-2.11194139" /energy="-6" /TU="U1464" /idTUdmin="U1461" /TUdmin=1584 /isTUend="FALSE" /label="downshifts" promotor_-35 1760620..1760623 /Source="Nicolas_upshift_promotors" /id="U1465" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.554445554445554" /psig="0.998001998001998" /xcortree=2328 /SigmaFactorBS="taaattcaaggatttttgctttttaattttaagatattGTTT gcgtattacggtgaAACAGATACAATAAAGCTTGaacagctttttttgaataccttgt c" /listShort="S672, parE, parC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1760638..1760657 /Source="Nicolas_upshift_promotors" /id="U1465" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.554445554445554" /psig="0.998001998001998" /xcortree=2328 /SigmaFactorBS="taaattcaaggatttttgctttttaattttaagatattGTTT gcgtattacggtgaAACAGATACAATAAAGCTTGaacagctttttttgaataccttgt c" /listShort="S672, parE, parC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1760642..1760956 /Source="Nicolas_S_feature" /locus_tag="new_1933162_1933476" /HighExp="H2O2, G150, G180, Etha, Oxctl, LBGexp, dia0, Lbexp, M40t45, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S672" upshifts 1760642 /Source="Nicolas_upshifts" /id="U1465" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.554445554445554" /psig="0.998001998001998" /xcortree=2328 /SigmaFactorBS="taaattcaaggatttttgctttttaattttaagatattGTTT gcgtattacggtgaAACAGATACAATAAAGCTTGaacagctttttttgaataccttgt c" /listShort="S672, parE, parC" /GFF_Attribute="listLong" /label="upshifts" CDS 1760957..1762924 /gene="parE" /locus_tag="BSU_18090" /old_locus_tag="BSU18090" /EC_number="5.99.1.3" /function="16.2: Construct biomass (Anabolism)" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:8969507, 9539793, 12682299, 16267290" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8969507, 9539793, 12682299, 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="subunit B of DNA topoisomerase IV (ATP-dependent)" /protein_id="NP_389691.2" /db_xref="EnsemblGenomes-Gn:BSU18090" /db_xref="EnsemblGenomes-Tr:CAB13692" /db_xref="GOA:Q59192" /db_xref="InterPro:IPR001241" /db_xref="InterPro:IPR002288" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR005740" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR013506" /db_xref="InterPro:IPR013759" /db_xref="InterPro:IPR013760" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR018522" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11804" /db_xref="UniProtKB/Swiss-Prot:Q59192" /translation="MARKQQFDYNEDAIQVLEGLEAVRKRPGMYIGSTDARGLHHLVY EIVDNSVDEVLAGHGDHIIVKIHKDNSISVQDRGRGMPTGMHKLGKPTPEVILTVLHA GGKFGQGGYKTSGGLHGVGASVVNALSEWLTVTIERDGFVYQQRFENGGKPVTSLEKI GKTKKTGTLTHFKPDPTMFSTTTYNFETLSERLRESAFLLKGLKIELIDERNDQREVF YYENGIEAFVAYLNEEKDVLSEVVSFEGEHHSIEVDFAFQFNDGYSENILSFVNNVRT KDGGTHESGAKTAMTRAFNEYARKVALLKEKDKNLEGTDIREGLSAIISVRIPEELLQ FEGQTKGKLGTSEARSAVDAIVSEQLAYFLEENRDTATLLVKKAIKASQAREAARKAR EEARSGKKRKKSEATLSGKLTPAGSRNPAKNELYLVEGDSAGGSAKQGRDRRFQAVLP LRGKVINTEKAKLADIFKNEEINTIIHAIGGGVGADFSIDDINYDKIIIMTDADTDGA HIQVLLLTFFYRYMKPLIEHGKVFIALPPLYKVSKGSGKKEIIEYAWSDEEMGDVLKK VGKGYTIQRYKGLGEMNADQLWETTMNPESRTLVRVKIDDAARVERRVTTLMGDKVEP RRKWIEKNVAFGLDEESNILENENLSVAEEV*" /label="parE CDS" gene 1760957..1762924 /gene="parE" /locus_tag="BSU_18090" /old_locus_tag="BSU18090" /label="parE gene" CDS 1762928..1765348 /gene="parC" /locus_tag="BSU_18100" /old_locus_tag="BSU18100" /EC_number="5.99.1.3" /function="16.2: Construct biomass (Anabolism)" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:9539793, 12682299, 16267290, 16272394, 24440393" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9539793, 12682299, 16267290, 16272394, 24440393; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="subunit A of DNA topoisomerase IV (ATP-dependent)" /protein_id="NP_389692.2" /db_xref="EnsemblGenomes-Gn:BSU18100" /db_xref="EnsemblGenomes-Tr:CAB13693" /db_xref="GOA:Q45066" /db_xref="InterPro:IPR002205" /db_xref="InterPro:IPR005741" /db_xref="InterPro:IPR006691" /db_xref="InterPro:IPR013757" /db_xref="InterPro:IPR013758" /db_xref="InterPro:IPR013760" /db_xref="InterPro:IPR024946" /db_xref="InterPro:IPR035516" /db_xref="SubtiList:BG11803" /db_xref="UniProtKB/Swiss-Prot:Q45066" /translation="MSQPELFHDLPLEEVIGDRFGRYSKYIIQDRALPDARDGLKPVQ RRILYAMHTDGNTFDKNFRKAAKTVGNVIGNYHPHGDSSVYEAMVRMSQDWKVRNVLI EMHGNNGSIDGDPPAAMRYTEARLSPIASELLRDIDKNTVEFVPNFDDTSKEPVVLPA MFPNLLVNGSTGISAGYATDIPPHHLGEVIDAVIKRIQMPSCSVDELMEVIKGPDFPT GGIIQGVDGIRKAYETGKGKIIIRGKAEIETIRGGREQIVITEIPFEVNKANLVKKMD EFRIDKKVEGISEVRDETDRTGLRVVIELKKEADAKGILNFLYKNTDLQITYNFNMVA IHNRRPMLMSLPSILDAYIGHQKEVVTNRSVYELQKAKDRHHIVEGLMKALSILDEVI ATIRSSSDKRDAKNNLIAKYEFTEPQAEAIVSLQLYRLTNTDITALKEEAEELGKKIE ELESILSNDKKLLKVITNSLKALKKKYADTRRSVIEEKIEEIKINLEVMVASEDVYVT VTKDGYLKRTSQRSFAASNGQDFGMKDTDRMLHQFEMNTTDVLLLFTNKGSYIYCPVH QLPDIRWKDMGQHFSNLITIDRDETIVKAIPIKEFDPSAYLLFFTKNGMVKKTELTHY KAQRYSKALVALNLKGEDELIDVHVTNGESQIFMATHLGYGLWFGEDEVNVVGARAAG VKGINLKEDDFVVSGEILQQSDSIVLFTQRGAVKRMSLSEFEKTSRAKRGVVMLRELK KNPHRVVALFACGLEQRLMAETEKGDRKELQTKELRTNDRYSNGSFFFDEEESGKVTA VWRLHTEQ*" /label="parC CDS" gene 1762928..1765348 /gene="parC" /locus_tag="BSU_18100" /old_locus_tag="BSU18100" /label="parC gene" downshifts 1765328 /Source="Nicolas_upshifts" /id="D991" /incds=0 /nref=227 /ntot=255 /MaxReadThrough="0.556700000000001" /MaxDrop="5.87714" /score="9.15080033" /energy="-14.6" /TU="NA" /idTUdmin="U1465" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1765356..1765545) /Source="Nicolas_S_feature" /locus_tag="new_1937876_1938065_c" /HighExp="LPhT, B60, Etha, B36, Gly, LoTm, Sw, BC, S8, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99806099999999998" /TUshortSig="SigA, SigA, SigK" /TUshortPSig="0.968, 0.994, 0.642" /TUlongSig="NA" /TUlongPSig="NA" /label="S673" CDS complement(1765395..1765571) /gene="ynfCc" /locus_tag="BSU_18109" /old_locus_tag="BSU18109" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein (C-terminus)" /db_xref="PSEUDO:SOX90559.1" /translation="MFNITRLCNENMRRLLNMLFILRMVILGLFSFTALNLFVWQGIE VIHAVTDLFTNHES*" /label="ynfCc CDS" gene complement(1765395..1765571) /gene="ynfCc" /locus_tag="BSU_18109" /old_locus_tag="BSU18109" /pseudo /label="ynfCc gene" downshifts complement(1765399) /Source="Nicolas_upshifts" /id="D992" /incds=0 /nref=153 /ntot=267 /MaxReadThrough="0.609599999999999" /MaxDrop="7.72532" /score="38.0779167" /energy="-14.6" /TU="NA" /idTUdmin="U1467" /TUdmin=5 /isTUend="TRUE" /label="downshifts" CDS complement(1765546..1765956) /gene="ynfCn" /locus_tag="BSU_18110" /old_locus_tag="BSU18110" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /db_xref="EnsemblGenomes-Gn:BSU18110" /db_xref="EnsemblGenomes-Tr:CAB13694" /db_xref="GOA:Q45067" /db_xref="PSEUDO:CAB13694.1" /db_xref="SubtiList:BG11828" /db_xref="UniProtKB/Swiss-Prot:Q45067" /translation="MDWGIIIKIFSNIKGGGDHLKKVTILKASILFLAIASFHLFSIP HAFDIGHHYKAVADQQEMHEMKAGQNADDEKKSITGAFTLTALWAMAVLLLTAESKST GYSRRRQRKKSFILAKFYQSSYFGKLHVQHHPIM*" /label="ynfCn CDS" gene complement(1765546..1765956) /gene="ynfCn" /locus_tag="BSU_18110" /old_locus_tag="BSU18110" /pseudo /label="ynfCn gene" promotor_-10 complement(1765929..1765948) /Source="Nicolas_upshift_promotors" /id="U1466" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.83016983016983" /psig="0.968031968031968" /xcortree=410 /SigmaFactorBS="tatttttaaatttaataaatcaGGTTTACTtttaggatggat tgGGGTATTATTATAAAAATATtcagtaatattaaaggagggggagatcatttgaaaa a" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1765932) /Source="Nicolas_upshifts" /id="U1466" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.83016983016983" /psig="0.968031968031968" /xcortree=410 /SigmaFactorBS="tatttttaaatttaataaatcaGGTTTACTtttaggatggat tgGGGTATTATTATAAAAATATtcagtaatattaaaggagggggagatcatttgaaaa a" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1765963..1765970) /Source="Nicolas_upshift_promotors" /id="U1466" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.83016983016983" /psig="0.968031968031968" /xcortree=410 /SigmaFactorBS="tatttttaaatttaataaatcaGGTTTACTtttaggatggat tgGGGTATTATTATAAAAATATtcagtaatattaaaggagggggagatcatttgaaaa a" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1765997..1766016) /Source="Nicolas_upshift_promotors" /id="U1467" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.994005994005994" /xcortree=2729 /SigmaFactorBS="cgctaataaaagaagttttcTCTTTCAAaaataagcaaaaag ATATATACTTAACAAAGTTAaatttatttttaaatttaataaatcaggtttactttta g" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1765998) /Source="Nicolas_upshifts" /id="U1467" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.994005994005994" /xcortree=2729 /SigmaFactorBS="cgctaataaaagaagttttcTCTTTCAAaaataagcaaaaag ATATATACTTAACAAAGTTAaatttatttttaaatttaataaatcaggtttactttta g" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1766031..1766038) /Source="Nicolas_upshift_promotors" /id="U1467" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.994005994005994" /xcortree=2729 /SigmaFactorBS="cgctaataaaagaagttttcTCTTTCAAaaataagcaaaaag ATATATACTTAACAAAGTTAaatttatttttaaatttaataaatcaggtttactttta g" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1766045..1766064) /Source="Nicolas_upshift_promotors" /id="U1468" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.642357642357642" /psig="0.642357642357642" /xcortree=722 /SigmaFactorBS="ctaaacaacatatcatttaaaatatgtttTTATTCACACcat aaaccgggtaTACATACGCTAATAAAAGAAgttttctctttcaaaaataagcaaaaag a" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1766056) /Source="Nicolas_upshifts" /id="U1468" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.642357642357642" /psig="0.642357642357642" /xcortree=722 /SigmaFactorBS="ctaaacaacatatcatttaaaatatgtttTTATTCACACcat aaaccgggtaTACATACGCTAATAAAAGAAgttttctctttcaaaaataagcaaaaag a" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1766078..1766087) /Source="Nicolas_upshift_promotors" /id="U1468" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.642357642357642" /psig="0.642357642357642" /xcortree=722 /SigmaFactorBS="ctaaacaacatatcatttaaaatatgtttTTATTCACACcat aaaccgggtaTACATACGCTAATAAAAGAAgttttctctttcaaaaataagcaaaaag a" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1766304..1766309 /Source="Nicolas_upshift_promotors" /id="U1469" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.400599400599401" /psig=1 /xcortree=2601 /SigmaFactorBS="gtaacatctggctatgacaatattcttctcgaaaaaaCTTCC TaattcgtcatatTGTGATATAATAAAACTCGTtatgttaaaaaatctaacatcaaaa t" /listShort="S674, alsT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1766322..1766341 /Source="Nicolas_upshift_promotors" /id="U1469" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.400599400599401" /psig=1 /xcortree=2601 /SigmaFactorBS="gtaacatctggctatgacaatattcttctcgaaaaaaCTTCC TaattcgtcatatTGTGATATAATAAAACTCGTtatgttaaaaaatctaacatcaaaa t" /listShort="S674, alsT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1766327 /Source="Nicolas_upshifts" /id="U1469" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.400599400599401" /psig=1 /xcortree=2601 /SigmaFactorBS="gtaacatctggctatgacaatattcttctcgaaaaaaCTTCC TaattcgtcatatTGTGATATAATAAAACTCGTtatgttaaaaaatctaacatcaaaa t" /listShort="S674, alsT" /GFF_Attribute="listLong" /label="upshifts" S_feature 1766340..1766404 /Source="Nicolas_S_feature" /locus_tag="new_1938860_1938924" /HighExp="Cold, G180, Oxctl, G135, LBGexp, G150, HPh, dia0, Lbexp, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S674" CDS 1766405..1767802 /gene="alsT" /locus_tag="BSU_18120" /old_locus_tag="BSU18120" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 8969507, 12823818, 15849754, 16850406, 22607086; Product type t : transporter" /codon_start=1 /transl_table=11 /product="H+/Na+:nitrogen-donor aminoacid symporter" /protein_id="NP_389694.1" /db_xref="EnsemblGenomes-Gn:BSU18120" /db_xref="EnsemblGenomes-Tr:CAB13695" /db_xref="GOA:Q45068" /db_xref="InterPro:IPR001463" /db_xref="SubtiList:BG11798" /db_xref="UniProtKB/Swiss-Prot:Q45068" /translation="MESFFNSLINIPSDFIWKYLFYILIGLGLFFTIRFGFIQFRYFI EMFRIVGEKPEGNKGVSSMQAFFISAASRVGTGNLTGVALAIATGGPGAVFWMWVVAA VGMASSFVESTLAQLYKVRDGEDFRGGPAYYIQKGLGARWLGIVFAILITVSFGLIFN AVQTNTIAGALDGAFHVNKIVVAIVLAVLTAFIIFGGLKRVVAVSQLIVPVMAGIYIL IALFVVITNITAFPGVIATIVKNALGFEQVVGGGIGGIIVIGAQRGLFSNEAGMGSAP NAAATAHVSHPAKQGFIQTLGVFFDTFIICTSTAFIILLYSVTPKGDGIQVTQAALNH HIGGWAPTFIAVAMFLFAFSSVVGNYYYGETNIEFIKTSKTWLNIYRIAVIAMVVYGS LSGFQIVWDMADLFMGIMALINLIVIALLSNVAYKVYKDYAKQRKQGLDPVFKAKNIP GLKNAETWEDEKQEA*" /label="alsT CDS" gene 1766405..1767802 /gene="alsT" /locus_tag="BSU_18120" /old_locus_tag="BSU18120" /label="alsT gene" downshifts 1767791 /Source="Nicolas_upshifts" /id="D993" /incds=0 /nref=112 /ntot=203 /MaxReadThrough="3.44078" /MaxDrop="5.75319" /score="16.664707" /energy="-14.7" /TU="U1469" /idTUdmin="U1469" /TUdmin="-23" /isTUend="FALSE" /label="downshifts" downshifts 1767836 /Source="Nicolas_upshifts" /id="D994" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="2.22962" /MaxDrop="5.03444" /score="16.664707" /energy="-14.7" /TU="NA" /idTUdmin="U1469" /TUdmin=22 /isTUend="TRUE" /label="downshifts" S_feature complement(1767892..1768638) /Source="Nicolas_S_feature" /locus_tag="new_1940412_1941158_c" /HighExp="S6, S8, S7, S5, BT, C30, B36, S4, LoTm, B60" /AntisenseName="eglS" /AntisenseCor="0.42607634596628102" /AntisenseRegPval="-12.6" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S675" promotor_-35 1768015..1768022 /Source="Nicolas_upshift_promotors" /id="U1470" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.585414585414585" /psig="0.995004995004995" /xcortree=1629 /SigmaFactorBS="ttgacaggcttttaaacctccccaaaacaagaaattaggttG ATAGACAatcatgagaaagATTTTTACAATGAGTTCGTGctcataagaagtgtagagc c" /listShort="eglS" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1768034 /Source="Nicolas_upshifts" /id="U1470" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.585414585414585" /psig="0.995004995004995" /xcortree=1629 /SigmaFactorBS="ttgacaggcttttaaacctccccaaaacaagaaattaggttG ATAGACAatcatgagaaagATTTTTACAATGAGTTCGTGctcataagaagtgtagagc c" /listShort="eglS" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1768035..1768054 /Source="Nicolas_upshift_promotors" /id="U1470" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.585414585414585" /psig="0.995004995004995" /xcortree=1629 /SigmaFactorBS="ttgacaggcttttaaacctccccaaaacaagaaattaggttG ATAGACAatcatgagaaagATTTTTACAATGAGTTCGTGctcataagaagtgtagagc c" /listShort="eglS" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1768105..1769604 /gene="eglS" /locus_tag="BSU_18130" /old_locus_tag="BSU18130" /EC_number="3.2.1.4" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:3024130, 7704256, 7710279, 15139916, 26907762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3024130, 7704256, 7710279, 15139916, 26907762; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endo-1,4-beta-glucanase" /protein_id="NP_389695.2" /db_xref="EnsemblGenomes-Gn:BSU18130" /db_xref="EnsemblGenomes-Tr:CAB13696" /db_xref="GOA:P10475" /db_xref="InterPro:IPR001547" /db_xref="InterPro:IPR001956" /db_xref="InterPro:IPR008965" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR018087" /db_xref="InterPro:IPR036966" /db_xref="PDB:2L8A" /db_xref="PDB:3PZT" /db_xref="PDB:3PZU" /db_xref="PDB:3PZV" /db_xref="SubtiList:BG10437" /db_xref="UniProtKB/Swiss-Prot:P10475" /translation="MKRSISIFITCLLITLLTMGGMIASPASAAGTKTPVAKNGQLSI KGTQLVNRDGKAVQLKGISSHGLQWYGEYVNKDSLKWLRDDWGITVFRAAMYTADGGY IDNPSVKNKVKEAVEAAKELGIYVIIDWHILNDGNPNQNKEKAKEFFKEMSSLYGNTP NVIYEIANEPNGDVNWKRDIKPYAEEVISVIRKNDPDNIIIVGTGTWSQDVNDAADDQ LKDANVMYALHFYAGTHGQFLRDKANYALSKGAPIFVTEWGTSDASGNGGVFLDQSRE WLKYLDSKTISWVNWNLSDKQESSSALKPGASKTGGWRLSDLSASGTFVRENILGTKD STKDIPETPSKDKPTQENGISVQYRAGDGSMNSNQIRPQLQIKNNGNTTVDLKDVTAR YWYKAKNKGQNFDCDYAQIGCGNVTHKFVTLHKPKQGADTYLELGFKNGTLAPGASTG NIQLRLHNDDWSNYAQSGDYSFFKSNTFKTTKKITLYDQGKLIWGTEPN*" /label="eglS CDS" gene 1768105..1769604 /gene="eglS" /locus_tag="BSU_18130" /old_locus_tag="BSU18130" /label="eglS gene" promotor_-10 complement(1768637..1768656) /Source="Nicolas_upshift_promotors" /id="U1471" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1389 /SigmaFactorBS="taccggttccgacaatgatgatgttgtctggatcatttttgC GGATAACTGaaatcacttcttcCGCATATGGTTTAATATCACgcttccagttcacatc a" /listShort="S675" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1768660) /Source="Nicolas_upshifts" /id="U1471" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1389 /SigmaFactorBS="taccggttccgacaatgatgatgttgtctggatcatttttgC GGATAACTGaaatcacttcttcCGCATATGGTTTAATATCACgcttccagttcacatc a" /listShort="S675" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1768670..1768679) /Source="Nicolas_upshift_promotors" /id="U1471" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1389 /SigmaFactorBS="taccggttccgacaatgatgatgttgtctggatcatttttgC GGATAACTGaaatcacttcttcCGCATATGGTTTAATATCACgcttccagttcacatc a" /listShort="S675" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1769552 /Source="Nicolas_upshifts" /id="D995" /incds=0 /nref=1 /ntot=89 /MaxReadThrough="3.59763" /MaxDrop="3.67571" /score="6.04626297" /energy="-10.7" /TU="NA" /idTUdmin="U1470" /TUdmin=1210 /isTUend="FALSE" /label="downshifts" CDS 1769672..1769935 /gene="ynfE" /locus_tag="BSU_18140" /old_locus_tag="BSU18140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389696.1" /db_xref="EnsemblGenomes-Gn:BSU18140" /db_xref="EnsemblGenomes-Tr:CAB13697" /db_xref="InterPro:IPR020302" /db_xref="SubtiList:BG11829" /db_xref="UniProtKB/Swiss-Prot:Q45069" /translation="MDEILKQYMVLYKKMSNMINGPDYPGKEKDIQHQKDQIEVYEKQ LQQGFSTDYDYDVFADSVIKCAYGDMTLEDLEAVYYGLTTPFF*" /label="ynfE CDS" gene 1769672..1769935 /gene="ynfE" /locus_tag="BSU_18140" /old_locus_tag="BSU18140" /label="ynfE gene" downshifts complement(1770194) /Source="Nicolas_upshifts" /id="D996" /incds=0 /nref=4 /ntot=148 /MaxReadThrough="1.78569" /MaxDrop="4.04338" /score="32.2414244" /energy="-12.6" /TU="NA" /idTUdmin="U1472" /TUdmin=6 /isTUend="TRUE" /label="downshifts" CDS complement(1770194..1771462) /gene="xynC" /locus_tag="BSU_18150" /old_locus_tag="BSU18150" /EC_number="3.2.1.136" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17028274, 25355936, 26559526, 28330222" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17028274, 25355936, 26559526, 28330222; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="secreted endo-xylanase" /protein_id="NP_389697.1" /db_xref="EnsemblGenomes-Gn:BSU18150" /db_xref="EnsemblGenomes-Tr:CAB13698" /db_xref="GOA:Q45070" /db_xref="InterPro:IPR001139" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR033452" /db_xref="PDB:3GTN" /db_xref="PDB:3KL0" /db_xref="PDB:3KL3" /db_xref="PDB:3KL5" /db_xref="SubtiList:BG11830" /db_xref="UniProtKB/Swiss-Prot:Q45070" /translation="MIPRIKKTICVLLVCFTMLSVMLGPGATEVLAASDVTVNVSAEK QVIRGFGGMNHPAWAGDLTAAQRETAFGNGQNQLGFSILRIHVDENRNNWYKEVETAK SAVKHGAIVFASPWNPPSDMVETFNRNGDTSAKRLKYNKYAAYAQHLNDFVTFMKNNG VNLYAISVQNEPDYAHEWTWWTPQEILRFMRENAGSINARVIAPESFQYLKNLSDPIL NDPQALANMDILGTHLYGTQVSQFPYPLFKQKGAGKDLWMTEVYYPNSDTNSADRWPE ALDVSQHIHNAMVEGDFQAYVWWYIRRSYGPMKEDGTISKRGYNMAHFSKFVRPGYVR IDATKNPNANVYVSAYKGDNKVVIVAINKSNTGVNQNFVLQNGSASNVSRWITSSSSN LQPGTNLTVSGNHFWAHLPAQSVTTFVVNR*" /label="xynC CDS" gene complement(1770194..1771462) /gene="xynC" /locus_tag="BSU_18150" /old_locus_tag="BSU18150" /label="xynC gene" S_feature complement(1771463..1771592) /Source="Nicolas_S_feature" /locus_tag="new_1943983_1944112_c" /HighExp="Lbstat, BC, M0t90, LBGstat, Sw, T2.0H, M40t90, BI, T1.30H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99419599999999997" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S676" CDS complement(1771593..1773134) /gene="xynD" /locus_tag="BSU_18160" /old_locus_tag="BSU18160" /EC_number="3.2.1.55" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1938968, 17426966, 26559526" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1938968, 17426966, 26559526; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arabinoxylan arabinofuranohydrolase" /protein_id="NP_389698.1" /db_xref="EnsemblGenomes-Gn:BSU18160" /db_xref="EnsemblGenomes-Tr:CAB13699" /db_xref="GOA:Q45071" /db_xref="InterPro:IPR005084" /db_xref="InterPro:IPR006584" /db_xref="InterPro:IPR006710" /db_xref="InterPro:IPR008979" /db_xref="InterPro:IPR023296" /db_xref="PDB:3C7E" /db_xref="PDB:3C7F" /db_xref="PDB:3C7G" /db_xref="PDB:3C7H" /db_xref="PDB:3C7O" /db_xref="SubtiList:BG11807" /db_xref="UniProtKB/Swiss-Prot:Q45071" /translation="MRKKCSVCLWILVLLLSCLSGKSAYAATSTTIAKHIGNSNPLID HHLGADPVALTYNGRVYIYMSSDDYEYNSNGTIKDNSFANLNRVFVISSADMVNWTDH GAIPVAGANGANGGRGIAKWAGASWAPSIAVKKINGKDKFFLYFANSGGGIGVLTADS PIGPWTDPIGKPLVTPSTPGMSGVVWLFDPAVFVDDDGTGYLYAGGGVPGVSNPTQGQ WANPKTARVIKLGPDMTSVVGSASTIDAPFMFEDSGLHKYNGTYYYSYCINFGGTHPA DKPPGEIGYMTSSSPMGPFTYRGHFLKNPGAFFGGGGNNHHAVFNFKNEWYVVYHAQT VSSALFGAGKGYRSPHINKLVHNADGSIQEVAANYAGVTQISNLNPYNRVEAETFAWN GRILTEKSTAPGGPVNNQHVTSIQNGDWIAVGNADFGAGGARSFKANVASTLGGKIEV RLDSADGKLVGTLNVPSTGGAQTWREIETAVSGATGVHKVFFVFTGTGTGNLFNFDYW QFTQR*" /label="xynD CDS" gene complement(1771593..1773134) /gene="xynD" /locus_tag="BSU_18160" /old_locus_tag="BSU18160" /label="xynD gene" S_feature complement(1773135..1773456) /Source="Nicolas_S_feature" /locus_tag="new_1945655_1945976_c" /HighExp="M0t90, LBGstat, T1.30H, T2.30H, BC, M9-stat, T2.0H, T3.0H, T0.30H, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.25588499999999997" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S677" promotor_-10 complement(1773446..1773465) /Source="Nicolas_upshift_promotors" /id="U1472" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.568431568431568" /psig="0.997002997002997" /xcortree=563 /SigmaFactorBS="ttgtagaatcgaacactaactcctccaaaagtttCTATacac aatttttttaATGATGTAGGATGTTAGATAaagggatatcttggataatgatgtaatc t" /listShort="S677, xynD, S676, xynC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1773457) /Source="Nicolas_upshifts" /id="U1472" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.568431568431568" /psig="0.997002997002997" /xcortree=563 /SigmaFactorBS="ttgtagaatcgaacactaactcctccaaaagtttCTATacac aatttttttaATGATGTAGGATGTTAGATAaagggatatcttggataatgatgtaatc t" /listShort="S677, xynD, S676, xynC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1773480..1773483) /Source="Nicolas_upshift_promotors" /id="U1472" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.568431568431568" /psig="0.997002997002997" /xcortree=563 /SigmaFactorBS="ttgtagaatcgaacactaactcctccaaaagtttCTATacac aatttttttaATGATGTAGGATGTTAGATAaagggatatcttggataatgatgtaatc t" /listShort="S677, xynD, S676, xynC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1773683..1773690 /Source="Nicolas_upshift_promotors" /id="U1473" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.502497502497502" /psig="0.99000999000999" /xcortree=1619 /SigmaFactorBS="cccgctttttcatgttttgttcatattttattaATTGTTTAt tcaacactgtcCGCTATAGTAATCCATATCAacaaatatgactgccactcgcatcttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1773703..1773722 /Source="Nicolas_upshift_promotors" /id="U1473" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.502497502497502" /psig="0.99000999000999" /xcortree=1619 /SigmaFactorBS="cccgctttttcatgttttgttcatattttattaATTGTTTAt tcaacactgtcCGCTATAGTAATCCATATCAacaaatatgactgccactcgcatcttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1773710 /Source="Nicolas_upshifts" /id="U1473" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.502497502497502" /psig="0.99000999000999" /xcortree=1619 /SigmaFactorBS="cccgctttttcatgttttgttcatattttattaATTGTTTAt tcaacactgtcCGCTATAGTAATCCATATCAacaaatatgactgccactcgcatcttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1773729..1774175 /gene="yngA" /locus_tag="BSU_18170" /old_locus_tag="BSU18170" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 20512483; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative conserved membrane protein possibly involved in arabinogalactan metabolism" /protein_id="NP_389699.1" /db_xref="EnsemblGenomes-Gn:BSU18170" /db_xref="EnsemblGenomes-Tr:CAB13700" /db_xref="GOA:O31821" /db_xref="InterPro:IPR007267" /db_xref="SubtiList:BG13452" /db_xref="UniProtKB/Swiss-Prot:O31821" /translation="MTATRIFYEGRFVTLKEKIKTLGRFCTVGVGNTLIDFGVFFLLT ACHVSYLPAQICSYTAGIVNSYVWNRNWTFCVKRKADGKEIVRFLMINIAASGITFLL LYLFQNCGCSLLVSKLAATIGGMMMNFIGNRIWVFGDSLKNIQDQE*" /label="yngA CDS" gene 1773729..1774175 /gene="yngA" /locus_tag="BSU_18170" /old_locus_tag="BSU18170" /label="yngA gene" CDS 1774182..1775075 /gene="yngB" /locus_tag="BSU_18180" /old_locus_tag="BSU18180" /EC_number="2.7.7.9" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8320212, 20512483; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative UTP-glucose-1-phosphate uridylyltransferase" /protein_id="NP_389700.1" /db_xref="EnsemblGenomes-Gn:BSU18180" /db_xref="EnsemblGenomes-Tr:CAB13701" /db_xref="GOA:O31822" /db_xref="InterPro:IPR005771" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG13453" /db_xref="UniProtKB/Swiss-Prot:O31822" /translation="MRKKVRKAVIPAAGLGTRFLPATKAQPKEMLPIVDKPAIQYIVE EAAESGIEDILIITGRNKRSIEDHFDRSAELEFNLREKGKTETLKEMQQIADLANIHY IRQKEPLGLGHAVLCAEHFIGDEPFAVLLGDDIMVSETPALRQLMDVYDVYGTEVVGV QSVLPEDVSKYGIINTSGSQGHVYEVNDLVEKPSPEEAPSEIAVMGRYVLNSSIFSVL KTIGRGAGNEIQLTDALREVCRKEPIHARLLEGNRYDIGDKLGCFKASTEIGLMRPEM RSQLLAYLEDVIKRETKEMLR*" /label="yngB CDS" gene 1774182..1775075 /gene="yngB" /locus_tag="BSU_18180" /old_locus_tag="BSU18180" /label="yngB gene" misc_feature 1774692..1774711 /Source="Nicolas_upshift_promotors" /id="U1474" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2146 /SigmaFactorBS="tggcacagaggttgtcggtgtacagtcagttctccctgagga tgtcagcaaaTATGGTATTATAAATACATCagggtctcaagggcatgtatatgaagtg a" /listShort="yngC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1774700 /Source="Nicolas_upshifts" /id="U1474" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2146 /SigmaFactorBS="tggcacagaggttgtcggtgtacagtcagttctccctgagga tgtcagcaaaTATGGTATTATAAATACATCagggtctcaagggcatgtatatgaagtg a" /listShort="yngC" /GFF_Attribute="listLong" /label="upshifts" CDS 1775148..1775744 /gene="yngC" /locus_tag="BSU_18190" /old_locus_tag="BSU18190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 20512483; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein, phosphatase or phosphate isomerase" /protein_id="NP_389701.1" /db_xref="EnsemblGenomes-Gn:BSU18190" /db_xref="EnsemblGenomes-Tr:CAB13702" /db_xref="GOA:O31823" /db_xref="InterPro:IPR032816" /db_xref="SubtiList:BG13454" /db_xref="UniProtKB/Swiss-Prot:O31823" /translation="MGSLISEILTWLTNMGYAGIAIGLMIEIIPSEIVLAYGGYMVSE GTIGFIGAIIAGVIGGTIAQIFIYWIGRYGGRPFLDKYGKYLLIKKHHIDMSENWFQK YGAGVVFSARFIPVVRHAISIPAGIARMPFLKFVVLTVLAIIPWSILFVYLGIQLGSQ WDDVENIAGTYTTPIMILAVVVIALYFVIKKRTAIFKR*" /label="yngC CDS" gene 1775148..1775744 /gene="yngC" /locus_tag="BSU_18190" /old_locus_tag="BSU18190" /label="yngC gene" downshifts 1775734 /Source="Nicolas_upshifts" /id="D997" /incds=0 /nref=191 /ntot=259 /MaxReadThrough="1.94273" /MaxDrop="5.58345" /score="15.4353025" /energy="-15" /TU="NA" /idTUdmin="U1474" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1775793..1776992) /gene="nrnB" /locus_tag="BSU_18200" /old_locus_tag="BSU18200" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:19553197, 22262096" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19553197, 22262096; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oligoribonuclease (nanoRNase)" /protein_id="NP_389702.1" /db_xref="EnsemblGenomes-Gn:BSU18200" /db_xref="EnsemblGenomes-Tr:CAB13703" /db_xref="GOA:O31824" /db_xref="SubtiList:BG13455" /db_xref="UniProtKB/Swiss-Prot:O31824" /translation="MYHLYSHNDLDGVGCGIVAKLAFGKDVEIRYNSVNGLNAQVQYF LEKAKESNRQDALFITDLAVNEENEERLNEYVHAGGKVKLIDHHKTALHLNEHEWGFV QVEYDDGRLTSATSLLYGYLIENGFMKPTNALDQFTELVRQYDTWEWERYDQKQAKRL NDLFFLLSIDEFEAKMIQRLSTHDEFFFDDFEEKLLDLEDEKIERYLRRKKREMVQTF VHEHCVGIVHAESYHSELGNRLGKDNPHLDYIAILSMGSKRVSLRTIHDYIDVSEIAG RYGGGGHAKASGCSITDEVYELFVAEAFRIDPVRPDAFRNIYNLKGSANGSLYENRAQ MRFFLFPLDNEWNIQINGETQDETFAAFEEAEWFIKRNYAASLVRDEVFVAFLAENLK LANQHRK*" /label="nrnB CDS" gene complement(1775793..1776992) /gene="nrnB" /locus_tag="BSU_18200" /old_locus_tag="BSU18200" /label="nrnB gene" S_feature complement(1776993..1777064) /Source="Nicolas_S_feature" /locus_tag="new_1949513_1949584_c" /HighExp="S5, S7, S4, S8, S6, ferm, nit, LBGstat, T5.0H, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.977" /TUlongSig="NA" /TUlongPSig="NA" /label="S678" promotor_-10 complement(1777052..1777063) /Source="Nicolas_upshift_promotors" /id="U1475" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=933 /SigmaFactorBS="atatatttacaataacaacattatgtcaactaattaccatTG CATAAaacgcttggtttttTAGAATAGTAAAtaaaggctgccgcacctctagcggcaa t" /listShort="S678, yngD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1777064) /Source="Nicolas_upshifts" /id="U1475" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=933 /SigmaFactorBS="atatatttacaataacaacattatgtcaactaattaccatTG CATAAaacgcttggtttttTAGAATAGTAAAtaaaggctgccgcacctctagcggcaa t" /listShort="S678, yngD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1777078..1777084) /Source="Nicolas_upshift_promotors" /id="U1475" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=933 /SigmaFactorBS="atatatttacaataacaacattatgtcaactaattaccatTG CATAAaacgcttggtttttTAGAATAGTAAAtaaaggctgccgcacctctagcggcaa t" /listShort="S678, yngD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1777162..1778697) /gene="ldeE" /locus_tag="BSU_18210" /old_locus_tag="BSU18210" /EC_number="6.4.1.4" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 19935659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylcrotonoyl-CoA carboxylase subunit (leucinedegradation)" /protein_id="NP_389703.2" /db_xref="EnsemblGenomes-Gn:BSU18210" /db_xref="EnsemblGenomes-Tr:CAB13704" /db_xref="GOA:O31825" /db_xref="InterPro:IPR011762" /db_xref="InterPro:IPR011763" /db_xref="InterPro:IPR029045" /db_xref="InterPro:IPR034733" /db_xref="SubtiList:BG13456" /db_xref="UniProtKB/Swiss-Prot:O31825" /translation="MLMDYEKERTERAERIRKGGAEKYHQSNREKGKLFVRERLSLLF DDDIELEDAFFAECMSDGLPADGVVTAIGKIGGQTVCVMANDSTVKAGSWGAKTVEKI IRIQEIAEKLNCPLIYLVDSAGARITDQINVFPGRRGAGRIFYNQVKLSGRIPQICLL FGPSAAGGAYIPAFCDIVVMVDGNASMYLGSPRMAEMVIGEKVSLEEMGGARMHCSIS GCGDILAETEEEAIQLVRAYLSYFPANFQEKAPIHEKRPPKHFETPLADVIPQNQNAP FDMHELIERVIDEDSFFEIKALFAPELLTGLARIHGQPVGIVANQPKVKGGVLFHDSA DKAAKFITLCDAFHIPLLFLADIPGFMIGTKVEQAGIIRHGAKMISAMSEATVPKLSV IVRKAYGAGLYAMAGPAFEPDCCLALPTAQIAVMGPEAAVNAVYAKKIAELPEEERAA FISSKREEYKEDINIYRLASEMIIDAVIPANSLRDELAKRLKAYMTKEMTFTNRKHPV YPV*" /label="ldeE CDS" gene complement(1777162..1778697) /gene="ldeE" /locus_tag="BSU_18210" /old_locus_tag="BSU18210" /label="ldeE gene" downshifts complement(1777174) /Source="Nicolas_upshifts" /id="D998" /incds=0 /nref=18 /ntot=38 /MaxReadThrough="1.74923" /MaxDrop="5.31437" /score="-1.4478995" /energy="-11.8" /TU="NA" /idTUdmin="U1477" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1778708..1779490) /gene="ldeF" /locus_tag="BSU_18220" /old_locus_tag="BSU18220" /EC_number="4.2.1.18" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 19935659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylglutaconyl-CoA hydratase (leucine degradation)" /protein_id="NP_389704.1" /db_xref="EnsemblGenomes-Gn:BSU18220" /db_xref="EnsemblGenomes-Tr:CAB13705" /db_xref="GOA:O34893" /db_xref="InterPro:IPR001753" /db_xref="InterPro:IPR014748" /db_xref="InterPro:IPR018376" /db_xref="InterPro:IPR029045" /db_xref="SubtiList:BG13457" /db_xref="UniProtKB/Swiss-Prot:O34893" /translation="MGDSILFTVKNEHMALITLNRPQAANALSAEMLRNLQMIIQEIE FNSNIRCVILTGTGEKAFCAGADLKERIKLKEDQVLESVSLIQRTAALLDALPQPVIA AINGSALGGGLELALACDLRIATEAAVLGLPETGLAIIPGAGGTQRLPRLIGRGKAKE FIYTGRRVTAHEAKEIGLVEHVTAPCDLMPKAEELAAAISANGPIAVRQAKFAINKGL ETDLATGLAIEQKAYEQTIPTKDRREGLQAFQEKRRAVYKGI*" /label="ldeF CDS" gene complement(1778708..1779490) /gene="ldeF" /locus_tag="BSU_18220" /old_locus_tag="BSU18220" /label="ldeF gene" CDS complement(1779511..1780410) /gene="ldeG" /locus_tag="BSU_18230" /old_locus_tag="BSU18230" /EC_number="4.1.3.4" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 16330546, 19935659, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="hydroxymethylglutaryl-CoA lyase (leucine degradation)" /protein_id="NP_389705.1" /db_xref="EnsemblGenomes-Gn:BSU18230" /db_xref="EnsemblGenomes-Tr:CAB13706" /db_xref="GOA:O34873" /db_xref="InterPro:IPR000891" /db_xref="InterPro:IPR013785" /db_xref="PDB:1YDO" /db_xref="SubtiList:BG13458" /db_xref="UniProtKB/Swiss-Prot:O34873" /translation="MPYPKKVTIKEVGPRDGLQNEPVWIATEDKITWINQLSRTGLSY IEITSFVHPKWIPALRDAIDVAKGIDREKGVTYAALVPNQRGLENALEGGINEACVFM SASETHNRKNINKSTSESLHILKQVNNDAQKANLTTRAYLSTVFGCPYEKDVPIEQVI RLSEALFEFGISELSLGDTIGAANPAQVETVLEALLARFPANQIALHFHDTRGTALAN MVTALQMGITVFDGSAGGLGGCPYAPGSSGNAATEDIVYMLEQMDIKTNVKLEKLLSA AKWIEEKMGKPLPSRNLQVFKSS*" /label="ldeG CDS" gene complement(1779511..1780410) /gene="ldeG" /locus_tag="BSU_18230" /old_locus_tag="BSU18230" /label="ldeG gene" CDS complement(1780425..1780646) /gene="lgeHB" /locus_tag="BSU_18239" /old_locus_tag="BSU18239" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type c: carrier" /codon_start=1 /transl_table=11 /product="methylcrotonyl-CoA carboxylase; biotinylated subunit (leucine degradation)" /protein_id="YP_003097733.1" /db_xref="EnsemblGenomes-Gn:BSU18239" /db_xref="EnsemblGenomes-Tr:CAX52627" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR011053" /db_xref="PDB:1Z6H" /db_xref="PDB:1Z7T" /db_xref="PDB:2B8F" /db_xref="PDB:2B8G" /db_xref="UniProtKB/Swiss-Prot:C0H419" /translation="MTVSIQMAGNLWKVHVKAGDQIEKGQEVAILESMKMEIPIVADR SGIVKEVKKKEGDFVNEGDVLLELSNSTQ*" /label="lgeHB CDS" gene complement(1780425..1780646) /gene="lgeHB" /locus_tag="BSU_18239" /old_locus_tag="BSU18239" /label="lgeHB gene" CDS complement(1780661..1781995) /gene="ldeHA" /locus_tag="BSU_18240" /old_locus_tag="BSU18240" /EC_number="6.4.1.4" /EC_number="6.3.4.14" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 7915138, 19935659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="biotin carboxylase for subunit LdeHB of methylcrotonyl-CoA carboxylase" /protein_id="NP_389706.1" /db_xref="EnsemblGenomes-Gn:BSU18240" /db_xref="EnsemblGenomes-Tr:CAB13707" /db_xref="GOA:O34544" /db_xref="InterPro:IPR005479" /db_xref="InterPro:IPR005481" /db_xref="InterPro:IPR005482" /db_xref="InterPro:IPR011054" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR011764" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="SubtiList:BG13459" /db_xref="UniProtKB/Swiss-Prot:O34544" /translation="MFTKVLIANRGEIAMRIIRTCSRLGIKTVAVYSEADKDAPHTKA ATEAYLIGESRVSESYLNIERIIKTAKKAKADAIHPGYGLLSENSRFAERCKQENIVF IGPSPDIIAKMGSKIEARKAMEAAGVPVVPGVSESLGDIEAACRTASQIGYPVMLKAS AGGGGIGMQRVENEEALKKAYEGNKKRAADFFGDGSMYIEKVIEHARHIEVQLLADQH GHTVHLFERDCSVQRRHQKVIEEAPSPFVDDELRMKIGQTAVKAAKAIGYTNAGTIEF IVDQKQNFYFLEMNTRLQVEHPVTEEITGLDLVEQQLRIAAGHTLTFSQKDIQRNGHA IEVRIYAEDPKTFFPSPGTITAFSLPDQKGVRHECAVAKDSTVTPFYDPMIAKMIVKG QTRTEAIEKLETALRDYRVEGIKTNLPLLIQAAATKAFKEGDVTTDFLKQHL*" /label="ldeHA CDS" gene complement(1780661..1781995) /gene="ldeHA" /locus_tag="BSU_18240" /old_locus_tag="BSU18240" /label="ldeHA gene" CDS complement(1782005..1783654) /gene="ldeI" /locus_tag="BSU_18250" /old_locus_tag="BSU18250" /EC_number="6.2.1.16" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12535077, 15213221, 19935659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetoacetyl-CoA synthetase" /protein_id="NP_389707.1" /db_xref="EnsemblGenomes-Gn:BSU18250" /db_xref="EnsemblGenomes-Tr:CAB13708" /db_xref="GOA:O31826" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="SubtiList:BG13460" /db_xref="UniProtKB/Swiss-Prot:O31826" /translation="MAELIHSTIGRLLEQTADAYPDRDAVVYPDRNIRYTYAQFDSLC RQTAKGLMRMGIGKGDHVAIWASNISEWLAVQFATAKIGAVLVTVNTNYQAHELDYLL KQSDAAALIIMDSYRGTSYPDIVNSLIPELQEAKPGQLKSERYPFLKTLIYIGNKRLS GMYHWDDTEILAKTVTDAELEERMNSLDKDNVINMQYTSGTTGFPKGVMLTHFNVINN AANIAECMALTSQDRMCIPVPFFHCFGCVLGVLACVSVGAAMIPVQEFDPVTVLKTVE KEKCTVLHGVPTMFIAELHHPDFDAYDLSTLRTGIMAGSPCPSEVMKAVIERMGMKDI TIAYGQTEASPVITQTRANDSFIRRVETTGRALPHTEVKIVEPGTCQEVQRGMQGELC TRGYHVMKGYYKDKDATRKAINHDGWLFTGDLAVMDEDGYCRITGRLKDMLIRGGENI YPREIEEFLYQHPAVLDVQVVGVPDAKFGEEAAAWIKLKDGKSVSPDELKAYCKGKIA RHKIPRYVIFTDDYPMTASGKIQKYKLREKTIEMFNLSSSQ*" /label="ldeI CDS" gene complement(1782005..1783654) /gene="ldeI" /locus_tag="BSU_18250" /old_locus_tag="BSU18250" /label="ldeI gene" promotor_no_box 1782054..1782154 /Source="Nicolas_upshift_promotors" /id="U1476" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.287712287712288" /psig="0.174825174825175" /xcortree=1695 /SigmaFactorBS="ttatatttttgaattttgcctgaggccgtcatcggatagtca tccgtaaaaataacataacgcggaattttgtggcgggcgattttccctttgcaatagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 1782114 /Source="Nicolas_upshifts" /id="U1476" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.287712287712288" /psig="0.174825174825175" /xcortree=1695 /SigmaFactorBS="ttatatttttgaattttgcctgaggccgtcatcggatagtca tccgtaaaaataacataacgcggaattttgtggcgggcgattttccctttgcaatagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1783698..1784840) /gene="ldeJ" /locus_tag="BSU_18260" /old_locus_tag="BSU18260" /EC_number="1.3.8.4" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 8655474, 17085570, 19935659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isovaleryl-CoA dehydrogenase (leucine degradation)" /protein_id="NP_389708.1" /db_xref="EnsemblGenomes-Gn:BSU18260" /db_xref="EnsemblGenomes-Tr:CAB13709" /db_xref="GOA:O34421" /db_xref="InterPro:IPR006089" /db_xref="InterPro:IPR006091" /db_xref="InterPro:IPR009075" /db_xref="InterPro:IPR009100" /db_xref="InterPro:IPR013786" /db_xref="InterPro:IPR036250" /db_xref="InterPro:IPR037069" /db_xref="SubtiList:BG13461" /db_xref="UniProtKB/Swiss-Prot:O34421" /translation="MNFELTKEQQMVREMVKDFAKKEIAPHAEHVDQTGEFPMQTFKK MGELGLMGIPFPEEYGGSGGDTISYALAVEEVGKACGSTGLSYAAAVSLGASPLYYFG TEEQKQTHLTPLASGTALGSFGLTEPNAGSDAGGTQTKAISNGDEYVINGEKCWITNA SYARTVIVTAVTGKNKDGKNIISALIVPTDTPGLTITSPYDKMGVRGSNTAEILLEDV RVPAANLLGDPTKGFKQFLYTLDGGRISIAALAVGIAQAALDASLAYAKERKQFGQPI SSFQAIQFKLADMAMEIDLARQMVLKAAWLKDHNRPFTKEAAYAKLFASEMATRACNQ AIQIHGGSGYMKEYGVERMLRDAKLMEIGEGTSEIQRLVIARQLLK*" /label="ldeJ CDS" gene complement(1783698..1784840) /gene="ldeJ" /locus_tag="BSU_18260" /old_locus_tag="BSU18260" /label="ldeJ gene" promotor_-10 complement(1784859..1784877) /Source="Nicolas_upshift_promotors" /id="U1477" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1156 /SigmaFactorBS="aaatgattcagttttaattttcagacttttcttgtcagGGAA TGattatagaactcgccTAATAGGATGTTACAAAGAtgtgaaggaggaaacgatgtga a" /listShort="yngJ, yngI, yngHA, yngHB, yngG, yngF, yngE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1784876) /Source="Nicolas_upshifts" /id="U1477" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1156 /SigmaFactorBS="aaatgattcagttttaattttcagacttttcttgtcagGGAA TGattatagaactcgccTAATAGGATGTTACAAAGAtgtgaaggaggaaacgatgtga a" /listShort="yngJ, yngI, yngHA, yngHB, yngG, yngF, yngE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1784893..1784898) /Source="Nicolas_upshift_promotors" /id="U1477" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1156 /SigmaFactorBS="aaatgattcagttttaattttcagacttttcttgtcagGGAA TGattatagaactcgccTAATAGGATGTTACAAAGAtgtgaaggaggaaacgatgtga a" /listShort="yngJ, yngI, yngHA, yngHB, yngG, yngF, yngE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1784931..1785236) /gene="ynzE" /locus_tag="BSU_18270" /old_locus_tag="BSU18270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389709.1" /db_xref="EnsemblGenomes-Gn:BSU18270" /db_xref="EnsemblGenomes-Tr:CAB13710" /db_xref="GOA:O34356" /db_xref="InterPro:IPR020509" /db_xref="SubtiList:BG13468" /db_xref="UniProtKB/Swiss-Prot:O34356" /translation="MLTDPAEEAFLPNFLLLGAGTALVLCLVFFLYQKLDQSQFAVIK LGIWGSAVGLLMDTISLWNLPLIFPALSKGQVIAFTIWMVCAYCMYLLIPLILSHKK* " /label="ynzE CDS" gene complement(1784931..1785236) /gene="ynzE" /locus_tag="BSU_18270" /old_locus_tag="BSU18270" /label="ynzE gene" CDS complement(1785226..1785399) /locus_tag="BSU_18275" /old_locus_tag="BSU18275" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_009513961.1" /translation="MNMEAVFGHLPLLESEKLVLNKNKIEEKHVQDVFYVFISSLVRC HIIFCAVRRCCVD*" /label="conserved protein of unknown function CDS" gene complement(1785226..1785399) /locus_tag="BSU_18275" /old_locus_tag="BSU18275" /label="gene" CDS complement(1785507..1787039) /gene="yngK" /locus_tag="BSU_18280" /old_locus_tag="BSU18280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative exported glycoside hydrolase" /protein_id="NP_389710.1" /db_xref="EnsemblGenomes-Gn:BSU18280" /db_xref="EnsemblGenomes-Tr:CAB13711" /db_xref="InterPro:IPR003790" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG13462" /db_xref="UniProtKB/Swiss-Prot:O35015" /translation="MKVCQKSIVRFLVSLIIGTFVISVPFMANAQSDRELRAVWIASV LNIDWPSKKGLSVKEQKQEYIKLLDDVQKMGMNAVIVQIKPTADAFYPSAYGPWSEYL TGVQGKDPGYDPLAFMIEETHKRNLEFHAWFNPYRITMNHTDLNKLSEDHPARKHPDW VAAYGNQLYYHPGIPEARDFIVKGIEEVVKHYDIDAVHMDDYFYPYKIAGQEFPDQAQ YEQYGKDAFSNIDDWRRDNVNQLVKQINQTIKAAKPYVKFGISPFGVWRNAADDPTGS NTKAGVRNYDDLYADTRHWIQEGDIDYIAPQIYWSIGFNAAAYDVLADWWSNEVKNRP VHLYIGQAAYKINNNFDPPWSDPEEYVRQITLNRQLELVKGSMHFSLKDLNKNPLGIK DSLSTDLYSKPALVPQMPWLDNTAPKKPKLTKVTEDKNGNLLQIKDHPSNQKTKETAY YAIYRAEGKKQRTLLATQRKTHEQQTFLDNTADPNKKYTYYVTSADRLHNESKASKRT TK*" /label="yngK CDS" gene complement(1785507..1787039) /gene="yngK" /locus_tag="BSU_18280" /old_locus_tag="BSU18280" /label="yngK gene" downshifts complement(1785518) /Source="Nicolas_upshifts" /id="D999" /incds=0 /nref=7 /ntot=27 /MaxReadThrough="2.27934" /MaxDrop="4.41371" /score="9.43133612" /energy="-8" /TU="NA" /idTUdmin="U1478" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1787074..1787093) /Source="Nicolas_upshift_promotors" /id="U1478" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1335 /SigmaFactorBS="tagtgagatagacattctgTTAATCACCCttttatagcccgG GAATACCGTAATAGCGAATagtgaaagtgatgtaatgggggagaagaaacagaatgaa g" /listShort="yngK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1787074) /Source="Nicolas_upshifts" /id="U1478" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1335 /SigmaFactorBS="tagtgagatagacattctgTTAATCACCCttttatagcccgG GAATACCGTAATAGCGAATagtgaaagtgatgtaatgggggagaagaaacagaatgaa g" /listShort="yngK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1787106..1787115) /Source="Nicolas_upshift_promotors" /id="U1478" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1335 /SigmaFactorBS="tagtgagatagacattctgTTAATCACCCttttatagcccgG GAATACCGTAATAGCGAATagtgaaagtgatgtaatgggggagaagaaacagaatgaa g" /listShort="yngK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1787175..1787567) /gene="yngL" /locus_tag="BSU_18290" /old_locus_tag="BSU18290" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735, 28163698; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_389711.1" /db_xref="EnsemblGenomes-Gn:BSU18290" /db_xref="EnsemblGenomes-Tr:CAB13712" /db_xref="GOA:O34506" /db_xref="InterPro:IPR010773" /db_xref="SubtiList:BG13463" /db_xref="UniProtKB/Swiss-Prot:O34506" /translation="MDRLSFLTFIMLILASYRLTHLIVFDKITEFIRKPFMKKKRIVD QNGHVDEKSVPASNFGYMLNCYWCAGVWCAILIGLGYLFLPRIAIPLIFILAIAGAQA ILETAVGVGVKLIDVLKSLQTMMNDKKS*" /label="yngL CDS" gene complement(1787175..1787567) /gene="yngL" /locus_tag="BSU_18290" /old_locus_tag="BSU18290" /label="yngL gene" downshifts complement(1787206) /Source="Nicolas_upshifts" /id="D1000" /incds=0 /nref=2 /ntot=18 /MaxReadThrough="0.581539999999999" /MaxDrop="2.96298" /score="5.25915686" /energy="-11.4" /TU="NA" /idTUdmin="U1479" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1787595..1787606) /Source="Nicolas_upshift_promotors" /id="U1479" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=852 /SigmaFactorBS="agaggccattctctgtccgtctttctttttgtatcaAGAATG GataagggacacttGGGAATGATAACatcatcctttttcttggaggcttctcaatgga c" /listShort="yngL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1787602) /Source="Nicolas_upshifts" /id="U1479" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=852 /SigmaFactorBS="agaggccattctctgtccgtctttctttttgtatcaAGAATG GataagggacacttGGGAATGATAACatcatcctttttcttggaggcttctcaatgga c" /listShort="yngL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1787620..1787626) /Source="Nicolas_upshift_promotors" /id="U1479" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=852 /SigmaFactorBS="agaggccattctctgtccgtctttctttttgtatcaAGAATG GataagggacacttGGGAATGATAACatcatcctttttcttggaggcttctcaatgga c" /listShort="yngL" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1787678..1791517) /gene="ppsE" /locus_tag="BSU_18300" /old_locus_tag="BSU18300" /EC_number="2.3.1.-" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9889147, 10471562, 12486459, 22720735, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9889147, 10471562, 12486459, 22720735, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nonribosomal plipastatin synthetase E" /protein_id="NP_389712.1" /db_xref="EnsemblGenomes-Gn:BSU18300" /db_xref="EnsemblGenomes-Tr:CAB13713" /db_xref="GOA:O31827" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR001031" /db_xref="InterPro:IPR001242" /db_xref="InterPro:IPR006162" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR020459" /db_xref="InterPro:IPR020802" /db_xref="InterPro:IPR020806" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="InterPro:IPR029058" /db_xref="InterPro:IPR036736" /db_xref="SubtiList:BG11962" /db_xref="UniProtKB/Swiss-Prot:O31827" /translation="MKKGADTMNTIKKIKNIYPLSHMQEGMLFHSFLRKEEGAYVEQS LFTIKGSLSYDWFQRSIQAIIDRHDIFRTVFLPHVPHLSGPRQVVMTEREFHLNSEDI SHLPTNDQNEYIERFKEKDKQKGFDLQKDMLMRISLFKTAKDEHVCIWSHHHILMDGW CLGIVMQEFMQIYQSIHAGKPLSLDPVRPYSTYISWLTNRDKEKAAAYWDTYLKNYSA PSPLPRVSDKETKESYHREDLIFSLNKPLTDKLKETAKQHGVTLATLIQAVWGVMLQQ YNRTDDVVFGAVVSGRPSEIPGVEQMIGLFINTIPIRIKTHQDETFHELLIRCQKEML EAEPFTCQPLFDIQANTALKQELIDHIIVFENYPLQQKIADSADQTDSPLQIDQVQVS EQSGYNFNLVVAPGEELVIKFSYNAFVYDAAWISCIKRQFTQALSTAAQHPHMPIADF SFLDATEKEQIVTQFNNTKTEYPKNHTIIDLFREQAEKTPDHTALVYGNMSISYKELD KRSNALARELIQKGFRKNETAGILAAHSPEFMISVLAVLKAGGAYLPLDAELPPERVS FMLEETQAKMLIVQKGLEQNAAFSGTCIISDAQGLMEENDIPINISSSPDDLAYIMYT SGSTGRPKGVMITNRNVVSLVRNSNYTSASGDDRFIMTGSISFDAVTFEMFGALLNGA SLHIIDKSTMLTPDRFGAYLLENDITVLFLTTALFNQLAQVRADMFRGLHTLYVGGEA LSPALMNAVRHACPDLALHNIYGPTENTTFSTFFEMKRDYAGPIPIGKPISNSTAYIL DTKGRLLPIGVPGELCVGGDGVAKGYLNRVDLTNAVFSPHPFLPGERIYRTGDLARWL PDGNLEYISRIDRQMKIRGKRIEPAEIEARLLEMEGVQEAAVTLREKDGEAQLYTHYV GDHKKTDTDFRADLARVLPDYMIPQHWVRVERMPLTGNGKIDRSALPIPENKPAKRQN IILPRNLVEEELANIWKQVLGVNTISIDDDFFAIGGHSLRALQVIHTLKHQQNIDIPI DFLFEHPTIAQLAEKLYSKQLTAANEQHVIKLNQHGAQNLFCFPPISGFGIYFKDLAL LLNEKAAVYGFHFIEQDTRIEQYVNCMTDIQPEGPYVLLGYSAGGNLAFEVAQAMERK GLEVSDFIIVDAYLKEQPLPIDTGNDESAAYLPEAVREKVMKKKRNYQEYWAQLLNEG HIKASIHFIEAGIHPETSGHTGLTKWEGACGNYSEYTGFGAHKDMLEGTYAEKNADII LDILEKITSNQVILHKR*" /label="ppsE CDS" gene complement(1787678..1791517) /gene="ppsE" /locus_tag="BSU_18300" /old_locus_tag="BSU18300" /label="ppsE gene" downshifts complement(1787690) /Source="Nicolas_upshifts" /id="D1001" /incds=0 /nref=51 /ntot=190 /MaxReadThrough="0.85603" /MaxDrop="4.50208" /score="20.3407616" /energy="-16.7" /TU="NA" /idTUdmin="U1479" /TUdmin="-484" /isTUend="FALSE" /label="downshifts" CDS complement(1791525..1802336) /gene="ppsD" /locus_tag="BSU_18310" /old_locus_tag="BSU18310" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9889147, 10471562, 16707694, 26284661, 28477175" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9889147, 10471562, 16707694, 26284661, 28477175; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nonribosomal plipastatin synthetase D involved in synthesis of plipastatin" /protein_id="NP_389713.2" /db_xref="EnsemblGenomes-Gn:BSU18310" /db_xref="EnsemblGenomes-Tr:CAB13714" /db_xref="GOA:P94459" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR001242" /db_xref="InterPro:IPR006162" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR010060" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR013321" /db_xref="InterPro:IPR020806" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="InterPro:IPR036736" /db_xref="SubtiList:BG11961" /db_xref="UniProtKB/Swiss-Prot:P94459" /translation="MTKANSIQDIYPLSYMQEGMLFHSLLQKDSQAYVEQASFTIEGK VNPQFFQNSINALVERHDIFRTIFISQNVSSPQQVVLRERNVIVLEEDITHLNEAEQS QFIEQWKEKDRDRGFHLQKDVLMRIALIQTGESQYSCIWTFHHIMMDGWCLSIVLKEF LHIYASYVNASPITLEPVQPYGKYIKWLMEQDKEQAVSYWDHYLSGHEQQTVLPKQKK TKGKSRQEHVTFSFSKEESSRLSELAAREEVTLSTIFHTIWGILLQKYNNNDDAVFGS VISGRPAEIEGIEHMVGLFINTMPVRVQGAKTPFLQLIKDMQKDRLAAEAYSYHPLYE IQSRSAVKQGLIDHILVFENYPVQQEIQMLNKQEHASDLFQIHNFTVADETNYSFYLM VAPGEEIHIKMNYDAEQHDRSFVLSVKEHLLNAVSQILNNPNLPPEEIDITTDTEKRQ LIGEITDQTPVYETIHAMFEKQAEKTPDAHAVIDQACSLTYRELNKAANRLARHLRMK GVVRQEPVAIMMERSAAFITGVLGILKAGGAIVPVDPHYPADRIRYILHDCGCSHVVS QAHLPSSLEDNYIITHPEDIESKVDGSNIKSVNNADDLLYMIYTSGTTGKPKGVQFEH RNMANLLKFEYTHSGIDFEADVLQFATPSFDVCYQEIFSALLKGGTLHIVPEAIKRDV PQLFAFINKHQTNIVFLPTAFIKMIFSERELANSFPDGVKHLIAAGEQLMISDLFQDV LRKRGIHLHNHYGPSETHVVSTYTIHPGDPIPELPPIGKPIGCTDLYILNHQKQLQPC GVPGELYISGASVARGYVNHDKLTSDKFSSDPFKPDVIMYRTGDLARRLEDGNIEYIG RADNQVKIRGYRIEPQEIEVTLMNHPDISEAAILIWQDQNGEHELCAYYCSVQKLNTI DLRSYMASELPEYMIPAKWIWVDSIPLTPNGKVDRAALPEPDASISGNPYTAPRNLLE AKLSQLFEDVLKNGHIGIQDNFFDNGGHSLKATVLMSRIAKEFHVQVSLKDIFAHPTV EGLALIIREAEQNLYAAIEPAEKRDTYPVSSAQKRIYVLQQLDEGVAYNMPAVLELEG ALDVAKLSAVCKELISRHEPLRTSFVSGADDEPVQRIHTEVPFTLSKETTIEGFVRPF DLSQAPLFRAGLIEVSNEKHVLLVDMHHIISDGVSVQLLIREFTDLYANRQLKPLRIQ YKDYAVWQQKFKKGDSYQKQETYWQQQFSGDLPILELPTDKRRPAERQFIGGKVTFQL DKEITARIKRLAHKNRSTLYMTLLALYSAFLSRLSGQDDIVIGSPIAGRPHADLEAVL GMFVNTLALRTRPAGNKTFEEFLKEVRQTALEAYEHQDYPFEELVDKLGVQREMSRNP LFDTTLVLQNMEQQKLKMNDVQLQWNDLEHPISKFDISLYVTEHDSELFCQFEYSTAL FEKETIQRWASLFTTLVEHTAASPETELDNIPILTKEEERDFIESCHLFEETGYSMNQ TLHYALEQQAEKTPDQAAVIFEDGVMTYKELNEQANRIAWELIGRGVKPETTVAIIGK RSPEMLLGIYGILKAGGAYLPIDPDYPEERISFLLEDSGTNILLLQSAGLHVPEFTGE IVYLNQTNSGLAHRLSNPNVDVLPQSLAYVIYTSGSTGMPKGVEIEHRSAVNFLNSLQ SRYQLKHSDMIMHKTSYSFDASIWELFWWPYAGASVYLLPQGGEKEPEVIAKAIEEQK ITAMHFVPSMLHAFLEHIKYRSVPIKTNRLKRVFSGGEQLGTHLVSRFYELLPNVSIT NSYGPTEATVEAAFFDCPPHEKLERIPIGKPVHHVRLYLLNQNQRMLPVGCIGELYIA GAGVARGYLNRPALTEERFLEDPFYPGERMYKTGDVARWLPDGNVEFLGRTDDQVKIR GYRIEPGEIEAALRSIEGVREAAVTVRTDSGEPELCAYVEGLQRNEVRAQLERLLPGY MVPAYMIEMEQWPVTPSGKLDRNALPAPGGAADAETYTAPRNVTEMKLSQLWEDVLKN GPVGIHDNFFDRGGHSLKATALVSRITKEFDVQVPLKDVFAHPTVEGLATVIREGTDS PYEAIKPAEKQETYPVSSAQKRIYVLQQLEDGGTGYNMPAVLELEGKLNPERMDRAFQ ELIKRHESLRTSFEQDEGGDPVQRIHDEVPFTLQTTVLGARTEQEAAAAFIKPFDLSQ APLFRAQIVKVSDERHLLLVDMHHIISDGVSVNILIQEFGELYNNRKLPALRIQYKDY AVWQEGFKTGDAYKMQEAYWLKQLEGELPVLDLPADHARPPVRSFAGDKVSFTLEPEV ASGLHKLARENGSTLYMVLLAAYTAFLSRLSGQEDIIVGSPIAGRPHKDLEPILGMFV NTLALRTRPEGGKPFVQYLQEVRETALEAFEHQNYPFEELVDKLELTRDMSRNPVFDA MLVVQNNDYEPLHLHDLQMKPAQVSHLVSKFDLTLQASEGDGNIHFLFEYSTALFEKT TIERWASHLTNVLSIIGKNPKVTLNHIDILTQEERHQLLNEFNTGQANQYGVQTISQL FEQQAARTPKASALVSGDKTLTYQELDEWSNGIARALRSRGVKPDTPVGIMMHRSFSM IASILGVWKAGGCYVPIDPEYPKERKRYILSDSGTKLLMTINEADLGVLADFEGEILT IESVEEDDKSPLPQMSSAHHLAYIIYTSGTTGRPKGVMVEHKGIANTLQWRRNAYAFN ETDTILQLFSFSFDGFITSMFTPLLSGAKAVLLHEEEAKDILAIKHQLSRQRITHMII VPVLYRALLDVVQPEDVKTLRVVTLAGEAADRELIARSLAICPHTELANEYGPTENSV ATTVMRHMEKQAYVSIGQPIDGTQVLILNSNHQLQPIGVAGELCIAGTGLARGYVNLP ELTERAFTQNPFKPEARMYRTGDAARWMADGTLEYLGRIDDQVKIRGYRVETKEIESV IRCIKGVKDAAVVAHVTASGQTELSAYVVTKPGLSTNAVRSELQNKLPVFMHPAFIEK LDSLPLSPNGKLDRGALPKPVYNHEGERPFLPPSSKMEQILADIWKEVLGAEKIGTAD SFFELGGDSIKALQVSARLHRIGKQMAVKDLFSHPTIQELAAYIRDSDTSSSQAAVEG DVQWSPVQKWFLSQDIKEKHHFNQSVMLHRSTSVQEDALRKTLKAITCHHDALRMVFT QNEQGKWDQYNRPLSHSDDALYGLQMIDLSAPDGTDGNRPYEPLIKRHVLDIQQKMDL KNGPLLQAGLFHTIDGDFLFLSAHHLVVDGISWRVLLEDLALGYRQAAGGEDIKLPPK TSSFKAYAKKLSDYAESQQLMKQLKYWREAEEYQTEALPFDQIDGTRAHEGQRSTISF TLNDKETAALLKDANSAYNTDTQDMLLASVILALRHWTNQSAFKLSLEGHGREDVLKG IDVSRTIGWFTAIYPLLIKLNADLPDSEESMVHVLKTTKDTLRRVPDKGFGYGVIKYL TPPGKKDINFTGAPEISFNYLGQFESGRTAEVPEEDAFSFSPLGAGGDISTTWNREQS LDISAIAAEGKLTVNMTYDNARFQRKTIEQLSETCRQFLLQLIEHCQNKSETEKTISD FDDQELTEDALQEIADMLSFH*" /label="ppsD CDS" gene complement(1791525..1802336) /gene="ppsD" /locus_tag="BSU_18310" /old_locus_tag="BSU18310" /label="ppsD gene" promotor_-35 1794545..1794548 /Source="Nicolas_upshift_promotors" /id="U1480" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.696303696303696" /psig="0.87012987012987" /xcortree=1814 /SigmaFactorBS="cgtaacagcctccggctttccacacaccaagtatggatgCTA TcatactgaacgaacgaTGCATCATGATGCCTACTGGtgtgtccggcttaacacctcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1794565..1794584 /Source="Nicolas_upshift_promotors" /id="U1480" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.696303696303696" /psig="0.87012987012987" /xcortree=1814 /SigmaFactorBS="cgtaacagcctccggctttccacacaccaagtatggatgCTA TcatactgaacgaacgaTGCATCATGATGCCTACTGGtgtgtccggcttaacacctcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1794566 /Source="Nicolas_upshifts" /id="U1480" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.696303696303696" /psig="0.87012987012987" /xcortree=1814 /SigmaFactorBS="cgtaacagcctccggctttccacacaccaagtatggatgCTA TcatactgaacgaacgaTGCATCATGATGCCTACTGGtgtgtccggcttaacacctcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1802361..1810028) /gene="ppsC" /locus_tag="BSU_18320" /old_locus_tag="BSU18320" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9889147, 10471562, 16707694, 26284661, 28477175" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9889147, 10471562, 16707694, 26284661, 28477175; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="non-ribosomal plipastatin synthetase C involved in synthesis of plipastatin" /protein_id="NP_389714.1" /db_xref="EnsemblGenomes-Gn:BSU18320" /db_xref="EnsemblGenomes-Tr:CAB13715" /db_xref="GOA:P39847" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR001242" /db_xref="InterPro:IPR006162" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR010060" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR020806" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="InterPro:IPR036736" /db_xref="SubtiList:BG10972" /db_xref="UniProtKB/Swiss-Prot:P39847" /translation="MPQQPEIQDIYPLSFMQEGMLFHSLYDEQSRAYFEQASFTIHGQ LDLERFQKSMDAVFDRYDIFRTAFIYKNVAKPRQVVLKQRHCPIHIEDISHLNERDKE HCTEAFKEQDKSKGFDLQTDVLMRISILKWAPDHYVCIWSHHHILMDGWCLGIVIKDF LHIYQALGKGQLPDLPPVQPYGTYIKWLMQQDREEAAEYWKKRLQHFEKSTPLPKRTD QIPNGTLQQITFAIPEKETAELQKIAAASGATLNTVFQALWGIMLQKVNRSSDAVFGS VISGRPSELKDVENMVGLFINTIPIRAQSDSLSFSDLVRRMQKDMNEAEAYSYFPLYD IQAQSALKQELIDHIIVFENTPTQQEIEELNQAGSFDFSVKDFEMEEVTNYSCSVKVI PGRTLYVRIHFQTSAYQPSMMSEIKDYLLHMVSDVISDPSLPVSKMTLLDEDKTRKIV SQNNRTVSVSPEAPTLHGLFERQAAVTPERLAIRFSGGSLTYAELDMYASRLAAHLAA RGVTNESIVGVLSERSPDMLIAVLAVLKAGGAYLPLDPAYPKERLSYMLKDSGASLLL TQPGCSAPNFSGETLEVDMTSLECEEVKRHVSASVSDGSLAYVIYTSGSTGQPKGVAV EHRQAVSFLTGMQHQFRLSEDDIVMVKTSFSFDASVWQLFWWALSGASAYLLPPGWEK DSALIVQAIHQENVTTAHFIPAMLNSFLDQAEIERLSDRTSLKRVFAGGEPLAPRTAA RFASVLPQVSLIHGYGPTEATVDAAFYVLDPERDRDRLRIPIGKPVPGARLYVLDPHL AVQPSGVAGELYIAGAGVARGYLNRPALTEERFLEDPFYLGERMYKTGDVARWLPDGN VEFLGRTDDQVKIRGYRIEPGEIEAALRSIEGVREAAVTVRTDSGEPELCAYVEGLQR NEVRAQLQRLLPGYMVPAYMIEMEQWPVTPSGKLDRNALPAPGGAADAETYTAPRNVT EMKLSQLWEDVLKNGPVGIHDNFFDRGGHSLKATALVSRIAKEFDVQVPLKDVFAHPT VEGLATVIREGTDSPYEAIKPAEKQETYPVSSAQKRIYVLQQLEDGGTGYNMPAVLEL EGKLNLERMDRAFKELIKRHESLRTAFEQDAGGDPVQRIHDEVPFTLQTTVLGARTEE EAAAAFIKPFDLSQAPLFRAQIVKVSDERHLLLVDMHHIISDGVSVNILIREFGELYN NRKLPALRIQYKDYAVWQEGFKTGDAYKTQGAYWLKQLEGELPVLDLPADHARPPMRS FAGDKVSFTLDQEVTSGLYKLARENGSTLYMVLLAAYTAFLSRLSGQEDIIVGSPIAG RPHKDLEPILGMFVNTLALRTRPEGGKPFVQYLQEVRETAMEAFEHQDYPFEELVDKL ELTRDMSRNPLFDVMFVLQNMDQESLELDELCLKPAANNGHQTSKFDLTLYAQEQPRG LLTFQMEFSTDLYKKKTIEKWLQYFNNMLLSIIKDNKAALGTINILNEDEAHYLIHEL NRTKIDYPRNETISRLFEMQAEQTPNAVAIVSDTQVFTYEDLNSWANQIASVLQIKGV GPDSVVALLTGRTPELIAGMLGILKAGGAYLPIDSNLPVERIAYMLSDSRAALLLQSE KTEKRLLGIECEQIIIEDIQKQGEAKNVESSAGPHSLAYIIYTSGSTGKPKGVMIEQR SVIRLVKNSNYITFTPEDRLLMTSSIGFDVGSFEIFGPLLNGAALHLSDQQTFLDSHQ LKRYIEHQGITTIWLTSSLFNHLTEQNEQTFSQLKHLIIGGEALSPSHVNRIRNVCPE VSIWNGYGPTENTTFSTCLHIQKTYELSIPIGRPVGNSTAFILNQWGVLQPVGAVGEL CVGGDGVARGYLGRPDLTKEKFVPHPFAPGDRLYRTGDLARWLSDGTIEYVGRIDDQV KVRGYRVELGEIETALRQIDGVKEAAVLARTAQTGSKELFGYISVKAGTNAEQVRSLL ARSLPNYMIPAYIIEMETLPLTSNGKLNRKALPEPDVASKQTYIPPRNELEEQLALIW QEVLGIQRIGIEDSFFELGGDSIKALQVSARLGRYGLSLQVSDLFRHPKIKDLSPFIR KSERIIEQGPIQGDVPWTPVQQWFFSQDIEERHHFNQSVMLFHSGRLSENALRPALKK LAEHHDALRMVYRNDDRRWIQINQGIHESQLYSLRISDLSQSESGWETKIKQEVADLQ QSINLQEGPLLHAALFKTLTGDYLFLAIHHLVVDGVSWRILLEDLSAGYQQAAAGQTI QLPPKTDSYQEYARRIQEYAQSSKLIREEAYWRSVEEQQAAELPYEIPHHVNIDFSKR DSLSFSLTEADTAVLLQNVNHAYGTDTQDILLTAASLAICEWTGGSKLRIAMEGHGRE HILPELDISRTVGWFTSMYPALISFENHRDELGTSVKTVKDTLGRIPNKGVGYGMLKY LTHPENKSITFSKTPEISFNYLGQFNDIERQDTFRPSSLGSGKDITHTWKREQIIEMS AMAADKKLHFNLSYPPARFHRNTMEQLINRIEHFLLDIMKHCAGQQKAEKTLSDFSSQ SLTAEDLDSISSLVEEL*" /label="ppsC CDS" gene complement(1802361..1810028) /gene="ppsC" /locus_tag="BSU_18320" /old_locus_tag="BSU18320" /label="ppsC gene" CDS complement(1810045..1817727) /gene="ppsB" /locus_tag="BSU_18330" /old_locus_tag="BSU18330" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9889147, 10471562, 16707694, 26284661, 28477175" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9889147, 10471562, 16707694, 26284661, 28477175; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nonribosomal plipastatin synthetase B involved in synthesis of plipastatin" /protein_id="NP_389715.1" /db_xref="EnsemblGenomes-Gn:BSU18330" /db_xref="EnsemblGenomes-Tr:CAB13716" /db_xref="GOA:P39846" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR001242" /db_xref="InterPro:IPR006162" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR010060" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR020806" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="InterPro:IPR036736" /db_xref="SubtiList:BG10971" /db_xref="UniProtKB/Swiss-Prot:P39846" /translation="MAQSAQIQDIYPLSHMQEGMLFHSLMDFSSKAYIEQTSFTITGN LCVDSFQKSLNLLVSRYDIFRTIFIKEVPDLTGPQQVVLSNRELTVYREDISRLADQE QQTLIDAFMTKDREKGFDLQKDPLMRLALFDRGDSQYTCVWTHHHIIMDGWCLGIILK EFFSMYDSLKNNSPVQLGSTVPYSRYIEWLGEQDQEETAAYWSEYLKEYGNTASIPRI KRRTADGNYKADQVSFSLAPDMVEKLTEAAQNWGVTLNTLFMSIWGVLLHRYNAADDA VFGSVISGRPSAIDGIESMVGLFINTVPVRIRSAEGITFSSLVKAVQEDILSSEQHGY YPLYEIQNHSPLKQGLIDHIFVFENYPVQLHQALSVESENDEGALKLSDISMSEQTNY DFNIVIVPGESFYIKFSYNADVYEREEMLRIQGHLKQALDCILTNPDVAVSDINIVPP EEQQVIQLFNETERPYVNKTIPQLFEEQAHKTPEAAALKMGNECWTYRQLQVRANQIA HALIEKGVGSGDIVAVMMGRSMEMPAALLGIWKAGGAYMPLDPHFPAERLSFLLKDSQ AAQLLIEEDLISLIPPSYEGNTITIEHTESYQTEAPNMPPGDLAYLIYTSGTTGRPKG VLVDHHGIANTLQWRREEYSMTEQDISLHLFSYVFDGCVTSLFTPLLSGACVLLTTDD EAKDVLALKRKIARYKVSHMIIVPSLYRVLLEVMTADDAKSLRIVTFAGEAVTPDLLE LNQIICPSAELANEYGPTENSVATTILRHLNKKERITIGHPIRNTKVFVLHGNQMQPI GAAGELCISGAGLARGYYKQQELTQKAFSDHPFLEGERLYRTGDAGRFLPDGTIEYIG RFDDQVKIRGYRIELREIETVLRQAPGVKEAAVLARDVSAEEKELVAYIVPEKGNSLP DLYQHLAGTLPSYMIPASIINISQMPLTSSGKLDRFALPEPENNTSVTYMAPRTLIEA DLAHIWEDVLNKQHIGIRDDFFQLGGQSLKAAALVSRIHKKLNVELPLSEVFSYPTVE SMAVKLMSLKEHAFTQIEPADQRDVYPLSFSQKRLYALHQLADDSTGYNMPAVLELRG NLNRQRLRSVLTELVNRHEALRTVFVLDRDEPVQIIYPEMAFDLKELEMESEQMLESA IETFIKPFYLSSGPLFRACVITMGNNRGFLLLDMHHIIADGVSMSTLVQEFTDLYCGK ELPALNLHYKDFAVWQQEKHPKELYKKQEAYWLGQLGGSLPTLELPLDKTRPRLPDFR GGTIEVNIDKDMADELHRLMAETGTTLYMILLAVYSILLSKLSGQEDIVVGSPAAGRP HADLERVIGMFVNTLAMRSKPEGHKTFSSYLHDIRHLALTAYEHQDYPFEELADKLDT NREVNRNPLFDAMLVLQSSEDFRFEVPGLSISSVTPKHDISKFDLTLHAEEHLSGIRC RFEYSTALFEEETITQWASYFIELVKGVTADTEMRISNMQLLPAAERRLLLEKMGQYA AYPRNENIVSLFEKQVAQYPEHIAVVCGHSQLTYRDLNEKAERAAAMLIKQGVRTGDI VGLMLDRSPDMIIGVLSILKAGGAYLPIDPEYPKERISFMLNDSGAKLLLTERGLNKP ADYTGHILYIDECENNSIPADVNIEEIVTDQPAYVIYTSGTTGQPKGVIVEHRNVISL LKHQNLPFEFNHEDVWTLFHSYCFDFSVWEMFGALLNGSTLVVVSKETARDPQAFRLL LKKERVTVLNQTPTAFYGLMLEDQNHTDHLNIRYVIFGGEALQPGLLQSWNEKYPHTD LINMYGITETTVHVTFKKLSAADIAKNKSNIGRPLSTLQAHVMDAHMNLQPTGVPGEL YIGGEGVARGYLNRDELTADRFVSNPYLPGDRLYRTGDLAKRLSNGELEYLGRIDEQV KVRGHRIELGEIQAALLQYPMIKEAAVITRADEQGQTAIYAYMVIKDQQAANISDIRT YLKNALPDFMLPARMIQIDSIPVTVNGKLDQKALPEPEKQAYTADDISPRNEIETVMA EIWEELLNVDELGVSANFFKLGGDSIKALQVCARLKQRGFETTVREMFEHQTLGELSA RVRKDVRAIDQGPVEGEITWTPIQQWFFSQSLESHHFNQSVMIYRAERFDEAALRKVL KSLVTHHDALRIVCRHEDGRQVQINRGIDLSDEELYALELFDVKDSLTEARNTIEEAA SRMQEHIRLETGPLLHAGLFRTENGDHLFLTIHHLVVDAVSWRILFEDFSTAYKQAVS GESIKLPQKTDSYLTYSQRIADYSISRQVQREAAYWDECENRHIQPIPKDNDAASNTF KDTEVIDFELSRHHTELLLTAAHKAYSTEMNDILLTALGLALQKWTGNNQFKISMEGH GRESYLEDIDISRTVGWFTSIYPVWLDMRDSDHKDKEERLGHLIKQTKDMLHRIPHKG AGYGVLKYISKRWGSQKNSPEISFNYLGQFDQDIQSNAFEVSDIKPGNEISPNWERPY ALDISGAVSSGCLNMHIIYNRFQFEEKTIQTFSRHFKQTLENIIEHCTGKENQEWSAS DFTDEDLTLDELSEIMGAVNKL*" /label="ppsB CDS" gene complement(1810045..1817727) /gene="ppsB" /locus_tag="BSU_18330" /old_locus_tag="BSU18330" /label="ppsB gene" downshifts complement(1813716) /Source="Nicolas_upshifts" /id="D1002" /incds=1 /nref=2 /ntot=18 /MaxReadThrough="4.83331" /MaxDrop="4.93461" /score="20.5621533" /energy="-10.2" /TU="U1481,U1483" /idTUdmin="U1481" /TUdmin="-5742" /isTUend="FALSE" /label="downshifts" upshifts complement(1813760) /Source="Nicolas_upshifts" /id="U1481" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.962037962037962" /psig="0.000999000999001" /xcortree=13 /SigmaFactorBS="agctaagcgggcaagaggatattgttgtcggttCGCCtgctg ccggaagaccgcACGCTgatctggagcgcgtcatcggaatgttcgtcaatacattggc g" /listShort="ppsC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1813762..1813766) /Source="Nicolas_upshift_promotors" /id="U1481" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.962037962037962" /psig="0.000999000999001" /xcortree=13 /SigmaFactorBS="agctaagcgggcaagaggatattgttgtcggttCGCCtgctg ccggaagaccgcACGCTgatctggagcgcgtcatcggaatgttcgtcaatacattggc g" /listShort="ppsC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1813784..1813787) /Source="Nicolas_upshift_promotors" /id="U1481" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.962037962037962" /psig="0.000999000999001" /xcortree=13 /SigmaFactorBS="agctaagcgggcaagaggatattgttgtcggttCGCCtgctg ccggaagaccgcACGCTgatctggagcgcgtcatcggaatgttcgtcaatacattggc g" /listShort="ppsC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1814063..1814067 /Source="Nicolas_upshift_promotors" /id="U1482" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.547452547452547" /psig="0.993006993006993" /xcortree=1818 /SigmaFactorBS="ccagtaggcctcctgttttttgtatagctctttcgggtgctt cTCTTGctgccaaacagcaaaATCCTTATAATGCAGGTTTAaagctggcaactctttt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1814080 /Source="Nicolas_upshifts" /id="U1482" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.547452547452547" /psig="0.993006993006993" /xcortree=1818 /SigmaFactorBS="ccagtaggcctcctgttttttgtatagctctttcgggtgctt cTCTTGctgccaaacagcaaaATCCTTATAATGCAGGTTTAaagctggcaactctttt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1814083..1814102 /Source="Nicolas_upshift_promotors" /id="U1482" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.547452547452547" /psig="0.993006993006993" /xcortree=1818 /SigmaFactorBS="ccagtaggcctcctgttttttgtatagctctttcgggtgctt cTCTTGctgccaaacagcaaaATCCTTATAATGCAGGTTTAaagctggcaactctttt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(1817752..1825437) /gene="ppsA" /locus_tag="BSU_18340" /old_locus_tag="BSU18340" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9889147, 10471562, 14762003, 16707694, 26284661, 26268540" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9889147, 10471562, 14762003, 16707694, 26284661, 26268540; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="non-ribosomal plipastatin synthetase A involved in synthesis of plipastatin" /protein_id="NP_389716.2" /db_xref="EnsemblGenomes-Gn:BSU18340" /db_xref="EnsemblGenomes-Tr:CAB13717" /db_xref="GOA:P39845" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR001242" /db_xref="InterPro:IPR006162" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR010060" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR020806" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="InterPro:IPR036736" /db_xref="SubtiList:BG10970" /db_xref="UniProtKB/Swiss-Prot:P39845" /translation="MSEHTYSLTHAQRRVWFTELLEPDTSICNLTACVKFKGNIELDT LEGALNHSISRNDAIRFQLLEGEELEPRLHLTEYKYYPLRIIDFSNVEMIEIEQWIQD QASIPFKLFNSPLFQFYLLRIDSHEVWLFAKFHHIIMDGISLNVMGNQIIDLYQKMKK KDPLPDQPEPSYLSYIEKESQYLQSPRFAKDRLFWTQTFEHPLEYHSLADQTSLQKQS TSASRDTIILSPDLEQTIRIFCEEHKINIISLFMASFYICISRITSKKDLAIGTYYGN RGSKAEKEMLGMFVSSLPIRITVDPDTDFLSFVRTIGREQLSVMRHQRFPYNLLVNEL RNEQKDLHNLIGISMQYQPLQWHNADDFDYETALYFSGYTANELSVQIQERIDNGTIQ LNFDYQNTLFSLEDIKRIQSHLLTILENALKHPHSFIRELDMTNTREKQKLLYEFNKT EAVSPKAFTLHGLFERQAAFTPERLAIRFSGGSLTYAELDMYASRLAAHLAARGVTNE SIVGVLSERSPDMLIAVLAVLKAGGAYLPLDPAYPKERLSYMLKDSGASLLLTQPGCS APNFSGETLEVDMTSLASEKAENHEFTPADGGSLAYVIYTSGSTGQPKGVAVEHRQAV SFLTGMQHQFPLSEDDIVMVKTSFSFDASVWQLFWWSLSGASAYLLPPGWEKDSALIV QAIHQENVTTAHFIPAMLNSFLDQAEIERLSDRTSLKRVFAGGEPLAPRTAARFASVL PQVSLIHGYGPTEATVDAAFYVLDPERDRDRLRIPIGKPVPGARLYVLDPHLAVQPSG VAGELYIAGAGVARGYLNRPALTEERFLEDPFYPGERMYKTGDVARWLPDGNVEFLGR TDDQVKIRGYRIEPGEIEAALRSIEGVREAAVTVRTDSGEPELCAYVEGLQRNEVRAQ LERLLPGYMVPAYMIEMEQWPVTPSGKLDRNALPAPGGAADAETYTAPRNVTEMKLSQ LWEDVLKNGPVGIHDNFFDRGGHSLKATALVSRIAKEFDVQVPLKDVFAHPTVEGLAT VIREGTDSPYEAIKPAEKQETYPVSSAQKRIYVLQQLEDGGTGYNMPAVLELEGKLNP ERMERAFKELIKRHESLRTSFEQDAGGDPVQRIHDEVPFTLQTTVLGERTEQEAAAAF IKPFDLSQAPLFRAQIVKISDERHLLLVDMHHIISDGVSVNILIREFGELYNNRNLPA LRIQYKDYAVWREGFKTGDAYKTQEAYWLKQLEGELPVLDLPADHARPPVRSFAGDKV SFTLDQEVASGLHKLARENGSTLYMVLLAAYTAFLSRLSGQEDIIVGSPIAGRPHKDL EPILGMFVNTLALRTRPEGGKPFVQYLQEVRETALEAFEHQDYPFEELVDKLELTRDM SRNPVFDAMFILQNVEKQDIDLREIKVRPANFAHHISLFDITLIATEISGSICCEMEF STEVFLKATIERWADHFIEFLHEALSTPETSLAQINILSDKEKQKIVFEFNKTQVEFA QKDIPFHRIFEAKAEENPEHIAVIDNETEISYRLLNERANRLARTLQNRKGPKPTVAV LAKRSIDAIVGVLAVMKAGGVYIPIDAHYPKARIEYILRDSGADILLLQRELKHLISN SPESEMSHIFLDDEGSFEESNCNLNLSPAPEEPVYIIYTSGTTGAPKGVIVTYQNFTH AALAWRQIYELDRKPVRLLQIASFSFDVFSGDLARTLTNGGTLIVCPDETRLEPAEIY KIIKSQRITVMESTPALIIPVMEYVYRNQFKLPDLDILILGSDMVKAQDFKTLTDRFG QSMRIINSYGVTEATIDSSFYETSMGGECTGDNVPIGSPLPNVHMYVLSQTDQIQPIG VAGELCIGGAGVAKGYHHKPDLTQMKFTENPFVSGERLYRTGDRACWLPNGTIRLLGR MDYQVKINGYRIETEEIESVLLQTGLVREAAVAVQHDKNGQAGLAAYIVPSDVNTNAL RAALTKELPAYMIPAYLIPLVNMPLTLNGKLDRNALPAPNNVLSRPYTAPVNDLQKTM AYIWEDVLSMSRVGIHDSFFELGGDSIKALQVAARLAAEGWSMTIRDLFRYSTIQELC GHITPLASQADQGPAEGEAELTPIQRRFFGQVHAFHYHYNQSVMLFSEKGFNANALHL ALRKITEHHDAIRMIFQRDQNGHVIQFNRGINHKDHELFGLYISDWTKASLERAHLDE KLAAEETVIQSKMNVEKGPLLQAGLFKTAEGDHLLIALHHLVIDGVSWRILLEDLAAA YQQALEKKEIQLPPKTDSYLSYADGLTQIAESKQLLSEKTYWQTILDAHTAFLPKDIE NVPDKLQMNSDAAAFVLSGDWTEKLLFETQQAYGTDANELLLTALGMALSEWTGHDQI VISTEGHGREGHVPNIDISRTVGWFTSIYPILLDMGIPEPFEDQLAYRIKTTKDMLRR VPNKGTGYGLLTHIGELRHKEPEVSFNYLGQFSEEKEVETFQLSYYQPRYEIAGERER EYELDINALITDGRLHVKAVYTQVFSKHSIECFMDRFHRHLIETIEHCSQKKAREKTL SDFSNKELTLSALSSIEDLVKDL*" /label="ppsA CDS" gene complement(1817752..1825437) /gene="ppsA" /locus_tag="BSU_18340" /old_locus_tag="BSU18340" /label="ppsA gene" S_feature complement(1825438..1825546) /Source="Nicolas_S_feature" /locus_tag="new_1997958_1998066_c" /HighExp="T1.30H, T1.0H, T0.30H, S1, M0t90, T2.30H, LPhT, C90, LoTm, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.982" /TUlongSig="NA" /TUlongPSig="NA" /label="S679" promotor_-10 complement(1825531..1825550) /Source="Nicolas_upshift_promotors" /id="U1483" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.428571428571429" /psig="0.982017982017982" /xcortree=557 /SigmaFactorBS="attcaaaaaaaatgttataaaaatttaatgtttttTATTGTA CtttaaaaaatatcCGTTAATATAGTGCATATATggattatatagtcatataatttct t" /listShort="S679, ppsA, ppsB, ppsC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1825546) /Source="Nicolas_upshifts" /id="U1483" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.428571428571429" /psig="0.982017982017982" /xcortree=557 /SigmaFactorBS="attcaaaaaaaatgttataaaaatttaatgtttttTATTGTA CtttaaaaaatatcCGTTAATATAGTGCATATATggattatatagtcatataatttct t" /listShort="S679, ppsA, ppsB, ppsC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1825564..1825571) /Source="Nicolas_upshift_promotors" /id="U1483" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.428571428571429" /psig="0.982017982017982" /xcortree=557 /SigmaFactorBS="attcaaaaaaaatgttataaaaatttaatgtttttTATTGTA CtttaaaaaatatcCGTTAATATAGTGCATATATggattatatagtcatataatttct t" /listShort="S679, ppsA, ppsB, ppsC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1825820..1827295) /gene="dacC" /locus_tag="BSU_18350" /old_locus_tag="BSU18350" /EC_number="3.4.16.4" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9733705, 9864321, 11160090, 14731276, 17582436, 19758330" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9733705, 9864321, 11160090, 14731276, 17582436, 19758330; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="D-alanyl-D-alanine carboxypeptidase" /protein_id="NP_389717.1" /db_xref="EnsemblGenomes-Gn:BSU18350" /db_xref="EnsemblGenomes-Tr:CAB13718" /db_xref="GOA:P39844" /db_xref="InterPro:IPR000667" /db_xref="InterPro:IPR012338" /db_xref="PDB:1W5D" /db_xref="PDB:2J9P" /db_xref="SubtiList:BG10969" /db_xref="UniProtKB/Swiss-Prot:P39844" /translation="MKKSIKLYVAVLLLFVVASVPYMHQAALAAEKQDALSGQIDKIL ADHPALEGAMAGITVRSAETGAVLYEHSGDTRMRPASSLKLLTAAAALSVLGENYSFT TEVRTDGTLKGKKLNGNLYLKGKGDPTLLPSDFDKMAEILKHSGVKVIKGNLIGDDTW HDDMRLSPDMPWSDEYTYYGAPISALTASPNEDYDAGTVIVEVTPNQKEGEEPAVSVS PKTDYITIKNDAKTTAAGSEKDLTIEREHGTNTITIEGSVPVDANKTKEWISVWEPAG YALDLFKQSLKKQGITVKGDIKTGEAPSSSDVLLSHRSMPLSKLFVPFMKLSNNGHAE VLVKEMGKVKKGEGSWEKGLEVLNSTLPEFGVDSKSLVLRDGSGISHIDAVSSDQLSQ LLYDIQDQSWFSAYLNSLPVAGNPDRMVGGTLRNRMKGTPAQGKVRAKTGSLSTVSSL SGYAETKSGKKLVFSILLNGLIDEEDGKDIEDQIAVILANQ*" /label="dacC CDS" gene complement(1825820..1827295) /gene="dacC" /locus_tag="BSU_18350" /old_locus_tag="BSU18350" /label="dacC gene" downshifts complement(1825832) /Source="Nicolas_upshifts" /id="D1003" /incds=0 /nref=126 /ntot=224 /MaxReadThrough="1.56173" /MaxDrop="5.81468" /score="20.5621533" /energy="-10.2" /TU="NA" /idTUdmin="U1484" /TUdmin="-16" /isTUend="TRUE" /label="downshifts" CDS complement(1827329..1828306) /gene="galM" /locus_tag="BSU_18360" /old_locus_tag="BSU18360" /EC_number="5.1.3.3" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9733705, 12753898, 19758330" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9733705, 12753898, 19758330; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aldose 1-epimerase" /protein_id="NP_389718.1" /db_xref="EnsemblGenomes-Gn:BSU18360" /db_xref="EnsemblGenomes-Tr:CAB13719" /db_xref="GOA:P39840" /db_xref="InterPro:IPR008183" /db_xref="InterPro:IPR011013" /db_xref="InterPro:IPR014718" /db_xref="PDB:3MWX" /db_xref="PDB:4BZE" /db_xref="PDB:4BZF" /db_xref="PDB:4BZG" /db_xref="PDB:4BZH" /db_xref="SubtiList:BG10253" /db_xref="UniProtKB/Swiss-Prot:P39840" /translation="MANFIEKITYLGTPAIKAGNEHLEMIVVPEWGSNVISLVDKTTN VQLLREPETAESFHDTPTLYGIPILFPPNRISDGTFSFRGRTYHFDINEKDKHNHLHG FLYHEKWNVVTTKQTDEGVIVETEIDLSELPHVQKQFPHHAVVRMTYTIKENTLFKHA TVMNKGKEAFPWGIGYHTTFIFPAESSLFSLTADQQWELDERLLPTGKLMDVPYKEAL HEGMDLRHKQLDDVFLSSYQKRGGENQAVIYHQHAHISIIYKADEQFKHWVVYNADGK QGYLCPEPYTWVTNAVNLDLPSSLTGLQVLEPGEETTAKSSITIELNHQ*" /label="galM CDS" gene complement(1827329..1828306) /gene="galM" /locus_tag="BSU_18360" /old_locus_tag="BSU18360" /label="galM gene" promotor_-10 complement(1828335..1828353) /Source="Nicolas_upshift_promotors" /id="U1484" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=537 /SigmaFactorBS="gtgtttttttatttgataggggaaaatataaaatGGAGGAAA TatggtacagtaCATTGAATTCTTATACTAGcaatgaatcaaggagaggttgagtaaa c" /listShort="yoxA, dacC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1828347) /Source="Nicolas_upshifts" /id="U1484" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=537 /SigmaFactorBS="gtgtttttttatttgataggggaaaatataaaatGGAGGAAA TatggtacagtaCATTGAATTCTTATACTAGcaatgaatcaaggagaggttgagtaaa c" /listShort="yoxA, dacC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1828365..1828373) /Source="Nicolas_upshift_promotors" /id="U1484" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=537 /SigmaFactorBS="gtgtttttttatttgataggggaaaatataaaatGGAGGAAA TatggtacagtaCATTGAATTCTTATACTAGcaatgaatcaaggagaggttgagtaaa c" /listShort="yoxA, dacC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1828440..1829831) /gene="yoeA" /locus_tag="BSU_18370" /old_locus_tag="BSU18370" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 28472044; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na+-driven efflux transporter" /protein_id="NP_389719.2" /db_xref="EnsemblGenomes-Gn:BSU18370" /db_xref="EnsemblGenomes-Tr:CAB13720" /db_xref="GOA:O34474" /db_xref="InterPro:IPR002528" /db_xref="SubtiList:BG13548" /db_xref="UniProtKB/Swiss-Prot:O34474" /translation="METSQEPLVTQKKSKPSVWRSMSLFLVPLLLSNVLQSVGQLVGM MAVGRWLGVDAVAAVSSFFPLFFLLISFTIGIGSGSSILIGQAYGAKNEERLKAVVGT TLTFTFLLGVVLAVIGSIFTLDILRLMGTPENVIHVSANYARILFYAMPFMFLYFAYT TFLRGTGDSKTPFYTLIVSTVINIALLPVLILGMFGFPKLGIYGSAYATVISTIATFL VLMVYLRKRKHPLQFDKTVRRYLKMDKELLVLLLRLGVPASINMILVSLSEIAVISFV NHYGSNATAAYGVVNQVASYVQMPAVSLGIAVSIFAAQSIGANEFDRLKQVIRVGIWL NYIIGGVLIILIYVFSHQILSLFLTEQETLYIAHRLLMITLWSYLLFGNAQIISATMR ASGTVLWPTVISIFAIWGVEVPVAFVLSHYTKLEILGVWVGYPAAFAVSLLLIYGYYQ FVWKKKQITRLIQ*" /label="yoeA CDS" gene complement(1828440..1829831) /gene="yoeA" /locus_tag="BSU_18370" /old_locus_tag="BSU18370" /label="yoeA gene" downshifts complement(1828454) /Source="Nicolas_upshifts" /id="D1004" /incds=0 /nref=74 /ntot=213 /MaxReadThrough="2.12119" /MaxDrop="5.14152" /score="31.8413544" /energy="-12.3" /TU="NA" /idTUdmin="U1486" /TUdmin=2 /isTUend="TRUE" /label="downshifts" downshifts 1828600 /Source="Nicolas_upshifts" /id="D1005" /incds=1 /nref=1 /ntot=3 /MaxReadThrough="1.76262" /MaxDrop="3.63403" /score="24.8192541" /energy="-9.3" /TU="NA" /idTUdmin="U1485" /TUdmin="-1452" /isTUend="FALSE" /label="downshifts" promotor_-35 1829621..1829627 /Source="Nicolas_upshift_promotors" /id="U1485" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=200 /SigmaFactorBS="acttcctgaaccgatcccaatcgtaaatgAGATTAAaagaaa aaataacGGGAAAAAGGATGATACAGctgccactgcatcaacaccgagccatctgcct a" /listShort="S680" /listLong="iseA" /label="promotor_-35" promotor_-10 1829641..1829659 /Source="Nicolas_upshift_promotors" /id="U1485" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=200 /SigmaFactorBS="acttcctgaaccgatcccaatcgtaaatgAGATTAAaagaaa aaataacGGGAAAAAGGATGATACAGctgccactgcatcaacaccgagccatctgcct a" /listShort="S680" /listLong="iseA" /label="promotor_-10" S_feature 1829652..1829985 /Source="Nicolas_S_feature" /locus_tag="new_2002172_2002505" /HighExp="M9-stat, Etha, Gly, S8, Sw, S7, B60, S6, Salt, C30" /AntisenseName="yoeA" /AntisenseCor="9.0133358617756607E-2" /AntisenseRegPval="-0.9" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S680" upshifts 1829652 /Source="Nicolas_upshifts" /id="U1485" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=200 /SigmaFactorBS="acttcctgaaccgatcccaatcgtaaatgAGATTAAaagaaa aaataacGGGAAAAAGGATGATACAGctgccactgcatcaacaccgagccatctgcct a" /listShort="S680" /listLong="iseA" /label="upshifts" S_feature complement(1829832..1829936) /Source="Nicolas_S_feature" /locus_tag="new_2002352_2002456_c" /HighExp="S8, LBGstat, Etha, Cold, S7, T-1.40H, S2, C90, nit, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.456" /TUlongSig="NA" /TUlongPSig="NA" /label="S681" promotor_no_box complement(1829896..1829996) /Source="Nicolas_upshift_promotors" /id="U1486" /multdbtbs="-" /comp="M1" /sig="Sig-" /pcomp="0.455544455544456" /psig="0.455544455544456" /xcortree=562 /SigmaFactorBS="ttacttgctagtttattcttcataagctaaaaagatgtgtaa aattagaagaatcgggaagggtttcataagtgcagtgatgaataataacatgttacat a" /listShort="S681, yoeA" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1829936) /Source="Nicolas_upshifts" /id="U1486" /multdbtbs="-" /comp="M1" /sig="Sig-" /pcomp="0.455544455544456" /psig="0.455544455544456" /xcortree=562 /SigmaFactorBS="ttacttgctagtttattcttcataagctaaaaagatgtgtaa aattagaagaatcgggaagggtttcataagtgcagtgatgaataataacatgttacat a" /listShort="S681, yoeA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1829958..1829963 /Source="Nicolas_upshift_promotors" /id="U1487" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1154 /SigmaFactorBS="tatgaaacccttcccgattcttctaattttaCACATCttttt agcttatgaaGAATAAACTAGCAAGTAATggcgtattttttgtgagtaaaagaataaa a" /listShort="iseA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1829979..1829997 /Source="Nicolas_upshift_promotors" /id="U1487" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1154 /SigmaFactorBS="tatgaaacccttcccgattcttctaattttaCACATCttttt agcttatgaaGAATAAACTAGCAAGTAATggcgtattttttgtgagtaaaagaataaa a" /listShort="iseA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1829987 /Source="Nicolas_upshifts" /id="U1487" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1154 /SigmaFactorBS="tatgaaacccttcccgattcttctaattttaCACATCttttt agcttatgaaGAATAAACTAGCAAGTAATggcgtattttttgtgagtaaaagaataaa a" /listShort="iseA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1830045..1830052 /Source="Nicolas_upshift_promotors" /id="U1488" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig="0.993006993006993" /xcortree=1549 /SigmaFactorBS="ttgtgagtaaaagaataaaaaataatttatgcaaaagTATTG TAAtctatccgtaatTATTGTAACATTTGTAACATaagagaaagagattttgaaggag a" /listShort="iseA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1830065..1830084 /Source="Nicolas_upshift_promotors" /id="U1488" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig="0.993006993006993" /xcortree=1549 /SigmaFactorBS="ttgtgagtaaaagaataaaaaataatttatgcaaaagTATTG TAAtctatccgtaatTATTGTAACATTTGTAACATaagagaaagagattttgaaggag a" /listShort="iseA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1830068 /Source="Nicolas_upshifts" /id="U1488" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig="0.993006993006993" /xcortree=1549 /SigmaFactorBS="ttgtgagtaaaagaataaaaaataatttatgcaaaagTATTG TAAtctatccgtaatTATTGTAACATTTGTAACATaagagaaagagattttgaaggag a" /listShort="iseA" /GFF_Attribute="listLong" /label="upshifts" CDS 1830117..1830662 /gene="iseA" /locus_tag="BSU_18380" /old_locus_tag="BSU18380" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:17483219, 17581128, 18761694, 22720735, 23091053" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17483219, 17581128, 18761694, 22720735, 23091053; Product type r: regulator" /codon_start=1 /transl_table=11 /product="inhibitor of DL-endopeptidases involved in cell-separation" /protein_id="NP_389720.2" /db_xref="EnsemblGenomes-Gn:BSU18380" /db_xref="EnsemblGenomes-Tr:CAB13721" /db_xref="InterPro:IPR031841" /db_xref="PDB:2RSX" /db_xref="SubtiList:BG13549" /db_xref="UniProtKB/Swiss-Prot:O34841" /translation="MKKCLLFLTTIALILSLSTNAFAKNTSGDLSQKQALQLALSARE HFWNTMSGHNPKVKKAVCPSGTFEYQNLQYVYMCSDLGTKAKAVNYLTPIFTKTAIEK GFKDYHFTVSKGKLAVPIGDGDNLLNWKKSTAKLISKKGSTITYEFTVPTLDGSPSAK RKVTFVKENKKWKVNQFDAVI*" /label="iseA CDS" gene 1830117..1830662 /gene="iseA" /locus_tag="BSU_18380" /old_locus_tag="BSU18380" /label="iseA gene" downshifts 1830646 /Source="Nicolas_upshifts" /id="D1006" /incds=0 /nref=164 /ntot=264 /MaxReadThrough="4.38689" /MaxDrop="8.27665" /score="24.8192541" /energy="-9.3" /TU="NA" /idTUdmin="U1487" /TUdmin=0 /isTUend="TRUE" /label="downshifts" tRNA complement(1830756..1830828) /gene="trnSL-Arg1" /locus_tag="BSU_tRNA_85" /product="tRNA-Arg" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Arg1 tRNA" gene complement(1830756..1830828) /gene="trnSL-Arg1" /locus_tag="BSU_tRNA_85" /label="trnSL-Arg1 gene" downshifts complement(1830854) /Source="Nicolas_upshifts" /id="D1007" /incds=0 /nref=4 /ntot=118 /MaxReadThrough="1.99821" /MaxDrop="3.03097" /score="3.94141467" /energy="-15.1" /TU="NA" /idTUdmin="U1489" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1830881..1831426) /gene="yoeC" /locus_tag="BSU_18390" /old_locus_tag="BSU18390" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative bacteriophage integrase" /protein_id="NP_389721.2" /db_xref="EnsemblGenomes-Gn:BSU18390" /db_xref="EnsemblGenomes-Tr:CAB13722" /db_xref="GOA:O35009" /db_xref="InterPro:IPR002104" /db_xref="InterPro:IPR011010" /db_xref="InterPro:IPR013762" /db_xref="SubtiList:BG13550" /db_xref="UniProtKB/Swiss-Prot:O35009" /translation="MHIVQPIRSLEKIQEVKQYLLNKNKRDYFLFIFGINSALRISDI LPLQVKDVQNKDHLWATESKTKKKRKILILESLKQEIYEYTKDMKENEYLFKSVRTRK PISRIQAYRILREAAAACGLEEIGTHTLRKTFGYHFYQRTKDIAELQRILNHSSPSIT MRYIGIDEDTTRAAYKVFGGL*" /label="yoeC CDS" gene complement(1830881..1831426) /gene="yoeC" /locus_tag="BSU_18390" /old_locus_tag="BSU18390" /label="yoeC gene" promotor_-10 complement(1831466..1831485) /Source="Nicolas_upshift_promotors" /id="U1489" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.642357642357642" /psig="0.999000999001" /xcortree=2388 /SigmaFactorBS="actatgtatattatgttacataaacgccgccgcaCTTTGACA ttcaacgtttttcAGCTATAATAGTAACATAGAcctcaaaatgttacataacggtttt t" /listShort="yoeC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1831480) /Source="Nicolas_upshifts" /id="U1489" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.642357642357642" /psig="0.999000999001" /xcortree=2388 /SigmaFactorBS="actatgtatattatgttacataaacgccgccgcaCTTTGACA ttcaacgtttttcAGCTATAATAGTAACATAGAcctcaaaatgttacataacggtttt t" /listShort="yoeC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1831499..1831506) /Source="Nicolas_upshift_promotors" /id="U1489" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.642357642357642" /psig="0.999000999001" /xcortree=2388 /SigmaFactorBS="actatgtatattatgttacataaacgccgccgcaCTTTGACA ttcaacgtttttcAGCTATAATAGTAACATAGAcctcaaaatgttacataacggtttt t" /listShort="yoeC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1831742..1831972) /gene="yoeD" /locus_tag="BSU_18400" /old_locus_tag="BSU18400" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16880568; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative excisionase" /protein_id="NP_389722.1" /db_xref="EnsemblGenomes-Gn:BSU18400" /db_xref="EnsemblGenomes-Tr:CAB13723" /db_xref="GOA:O34555" /db_xref="InterPro:IPR010093" /db_xref="SubtiList:BG13551" /db_xref="UniProtKB/Swiss-Prot:O34555" /translation="MYLTIEETAEYTNLSEDYIKSLVLEGKIRAVHDGEQFLIYKEQF KTHLEQLENYKALVQEILNEPIPEDIDVKDED*" /label="yoeD CDS" gene complement(1831742..1831972) /gene="yoeD" /locus_tag="BSU_18400" /old_locus_tag="BSU18400" /label="yoeD gene" downshifts complement(1831756) /Source="Nicolas_upshifts" /id="D1008" /incds=0 /nref=193 /ntot=248 /MaxReadThrough="0.81591" /MaxDrop="5.75977" /score="19.8797745" /energy="-8.6" /TU="NA" /idTUdmin="U1490" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1831998..1832017) /Source="Nicolas_upshift_promotors" /id="U1490" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.931068931068931" /psig=1 /xcortree=2156 /SigmaFactorBS="atagtgcataatgccgtttttctgtgcagaattgaTTATATT gatatgagccaTGTGCTATATTAGAATCAGCatacggattaagaagggactgctatat g" /listShort="yoeD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1832010) /Source="Nicolas_upshifts" /id="U1490" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.931068931068931" /psig=1 /xcortree=2156 /SigmaFactorBS="atagtgcataatgccgtttttctgtgcagaattgaTTATATT gatatgagccaTGTGCTATATTAGAATCAGCatacggattaagaagggactgctatat g" /listShort="yoeD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1832029..1832035) /Source="Nicolas_upshift_promotors" /id="U1490" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.931068931068931" /psig=1 /xcortree=2156 /SigmaFactorBS="atagtgcataatgccgtttttctgtgcagaattgaTTATATT gatatgagccaTGTGCTATATTAGAATCAGCatacggattaagaagggactgctatat g" /listShort="yoeD" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1832064..1832083) /Source="Nicolas_upshift_promotors" /id="U1491" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.656343656343656" /psig="0.971028971028971" /xcortree=1438 /SigmaFactorBS="gtattgttacaatcttagcgtaaaaaaattacagcgttttca caagtgacaAATGGTATATTATATAGTGCataatgccgtttttctgtgcagaattgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1832074) /Source="Nicolas_upshifts" /id="U1491" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.656343656343656" /psig="0.971028971028971" /xcortree=1438 /SigmaFactorBS="gtattgttacaatcttagcgtaaaaaaattacagcgttttca caagtgacaAATGGTATATTATATAGTGCataatgccgtttttctgtgcagaattgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1832087..1832094 /Source="Nicolas_upshift_promotors" /id="U1492" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.763236763236763" /psig=1 /xcortree=470 /SigmaFactorBS="aaacggcattatgcactatataatataccatttgtCACTTGT GaaaacgctgtaatTTTTTTACGCTAAGATTGTAacaatacagcttcatataggaggg a" /listShort="ggt" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1832108..1832127 /Source="Nicolas_upshift_promotors" /id="U1492" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.763236763236763" /psig=1 /xcortree=470 /SigmaFactorBS="aaacggcattatgcactatataatataccatttgtCACTTGT GaaaacgctgtaatTTTTTTACGCTAAGATTGTAacaatacagcttcatataggaggg a" /listShort="ggt" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1832112 /Source="Nicolas_upshifts" /id="U1492" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.763236763236763" /psig=1 /xcortree=470 /SigmaFactorBS="aaacggcattatgcactatataatataccatttgtCACTTGT GaaaacgctgtaatTTTTTTACGCTAAGATTGTAacaatacagcttcatataggaggg a" /listShort="ggt" /GFF_Attribute="listLong" /label="upshifts" CDS 1832157..1833920 /gene="ggt" /locus_tag="BSU_18410" /old_locus_tag="BSU18410" /EC_number="2.3.2.2" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8763966, 23335395, 24279353, 26370226, 28120195" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8763966, 23335395, 24279353, 26370226, 28120195; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="membrane bound gamma-glutamyltranspeptidase" /protein_id="NP_389723.1" /db_xref="EnsemblGenomes-Gn:BSU18410" /db_xref="EnsemblGenomes-Tr:CAB13724" /db_xref="GOA:P54422" /db_xref="InterPro:IPR000101" /db_xref="InterPro:IPR029055" /db_xref="PDB:2V36" /db_xref="PDB:3A75" /db_xref="PDB:3WHQ" /db_xref="PDB:3WHR" /db_xref="PDB:3WHS" /db_xref="SubtiList:BG11838" /db_xref="UniProtKB/Swiss-Prot:P54422" /translation="MKRTWNVCLTALLSVLLVAGSVPFHAEAKKPPKSYDEYKQVDVG KDGMVATAHPLASEIGADVLKKGGNAIDAAVAIQFALNVTEPMMSGIGGGGFMMVYDG KTKDTTIIDSRERAPAGATPDMFLDENGKAIPFSERVTKGTAVGVPGTLKGLEEALDK WGTRSMKQLITPSIKLAEKGFPIDSVLAEAISDYQEKLSRTAAKDVFLPNGEPLKEGD TLIQKDLAKTFKLIRSKGTDAFYKGKFAKTLSDTVQDFGGSMTEKDLENYDITIDEPI WGDYQGYQIATTPPPSSGGIFLLQMLKILDHFNLSQYDVRSWEKYQLLAETMHLSYAD RASYAGDPEFVNVPLKGLLHPDYIKERQQLINLDQVNKKPKAGDPWKYQEGSANYKQV EQPKDKVEGQTTHFTVADRWGNVVSYTTTIEQLFGTGIMVPDYGVILNNELTDFDAIP GGANEVQPNKRPLSSMTPTILFKDDKPVLTVGSPGGATIISSVLQTILYHIEYGMELK AAVEEPRIYTNSMSSYRYEDGVPKDVLSKLNGMGHKFGTSPVDIGNVQSISIDHENGT FKGVADSSRNGAAIGINLKRK*" /label="ggt CDS" gene 1832157..1833920 /gene="ggt" /locus_tag="BSU_18410" /old_locus_tag="BSU18410" /label="ggt gene" downshifts 1833901 /Source="Nicolas_upshifts" /id="D1009" /incds=0 /nref=24 /ntot=49 /MaxReadThrough="1.41914" /MaxDrop="5.80171" /score="3.23845421" /energy="-10.4" /TU="NA" /idTUdmin="U1492" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1834021..1834878) /gene="ftsR" /locus_tag="BSU_18420" /old_locus_tag="BSU18420" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17526699" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17526699; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (LysR family)" /protein_id="NP_389724.1" /db_xref="EnsemblGenomes-Gn:BSU18420" /db_xref="EnsemblGenomes-Tr:CAB13725" /db_xref="GOA:O34685" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13552" /db_xref="UniProtKB/Swiss-Prot:O34685" /translation="MESGDLKIFQAVAREGSITKAAQMLNYVQSNVTARVHNLEEDLN IRLFHRTNRGMKLTAAGENLLQYADQVLSLLDQAEKSTRMSRQPKGPLRIGSLETMAV THLPEHAASFLRRFPEVDLSVNTADTHHLIQQVLDHKVDGAFVYGPVEHAAVRQLHVS HDELVLISSREGTAEDMLQQPMLFFGAGCSHRDRVKRLLEEAGIHNQKIIEFGTLEAI IKGVSAGMGTALLPKSAVDGSEHRTNVWIHQLPPSYQDLEIVFIYRKDFFITSAFQTF LDEINEMKR*" /label="ftsR CDS" gene complement(1834021..1834878) /gene="ftsR" /locus_tag="BSU_18420" /old_locus_tag="BSU18420" /label="ftsR gene" promotor_-10 complement(1834924..1834943) /Source="Nicolas_upshift_promotors" /id="U1493" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.632367632367632" /psig="0.998001998001998" /xcortree=3011 /SigmaFactorBS="ctgtctgcctcctcattaattgtattttcatatctttacaTA TTTTACatagcggttttctTCGAGTAAAATGAACAAATAtgatagccaatatcacttt t" /listShort="ftsR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1834944) /Source="Nicolas_upshifts" /id="U1493" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.632367632367632" /psig="0.998001998001998" /xcortree=3011 /SigmaFactorBS="ctgtctgcctcctcattaattgtattttcatatctttacaTA TTTTACatagcggttttctTCGAGTAAAATGAACAAATAtgatagccaatatcacttt t" /listShort="ftsR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1834957..1834964) /Source="Nicolas_upshift_promotors" /id="U1493" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.632367632367632" /psig="0.998001998001998" /xcortree=3011 /SigmaFactorBS="ctgtctgcctcctcattaattgtattttcatatctttacaTA TTTTACatagcggttttctTCGAGTAAAATGAACAAATAtgatagccaatatcacttt t" /listShort="ftsR" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1835006..1835995 /gene="yogA" /locus_tag="BSU_18430" /old_locus_tag="BSU18430" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106, 23873705; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_389725.1" /db_xref="EnsemblGenomes-Gn:BSU18430" /db_xref="EnsemblGenomes-Tr:CAB13726" /db_xref="GOA:O35017" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13553" /db_xref="UniProtKB/Swiss-Prot:O35017" /translation="MKAVIHNGKAGLLGLSVQDVPSTKPGYGEVKVKLKSAGLNHRDL FLMKNKSEQDPHMILGSDGAGIIEEIGEGVKNVTVQTEVVIFPTLNWDLTENVPPVPE ILGGPSDGTLAEYVIIPSQNAIKKPAYLSWEEAGVLPLSALTAYRALFTKGQLKKGEH LLIPGIGSGVATYALFMAKAIGATVSVTSRSEEKRKKALKLGADYAFDSYSNWDEQLQ GKKIDVVLDSIGPALFSEYFRHVKPNGRIVSFGASSGDNLSFPVRSLFFPQVNVLGTS MGSGEEFQAMLAFIDKHKLRPVIDRIYPLEKACEAYKRMQEGRQFGNIGIVME*" /label="yogA CDS" gene 1835006..1835995 /gene="yogA" /locus_tag="BSU_18430" /old_locus_tag="BSU18430" /label="yogA gene" S_feature complement(1835062..1836020) /Source="Nicolas_S_feature" /locus_tag="new_2007582_2008540_c" /HighExp="T-4.40H, T-5.40H, Glu, GM 45, Glucon, GM-0.1, Gly, GM-0.2, UNK1, GM 90" /AntisenseName="yogA" /AntisenseCor="-0.49303153269799599" /AntisenseRegPval="-17.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S682" CDS complement(1836052..1837533) /gene="gltB" /locus_tag="BSU_18440" /old_locus_tag="BSU18440" /EC_number="1.4.1.13" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3011766, 10651638, 11029411, 27223617" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3011766, 10651638, 11029411, 27223617; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate synthase (small subunit, NADP-dependent)" /protein_id="NP_389726.2" /db_xref="EnsemblGenomes-Gn:BSU18440" /db_xref="EnsemblGenomes-Tr:CAB13727" /db_xref="GOA:O34399" /db_xref="InterPro:IPR006005" /db_xref="InterPro:IPR009051" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR028261" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG12594" /db_xref="UniProtKB/Swiss-Prot:O34399" /translation="MGKPTGFMEIKREKPAERDPLTRLKDWKEYSAPFSEEASKRQGA RCMDCGTPFCQIGADINGFTSGCPIYNLIPEWNDLVYRGRWKEALERLLKTNNFPEFT GRVCPAPCEGSCTLAISDPAVSIKNIERTIIDKGFENGWIQPRIPKKRTGKKVAIVGS GPAGLASADQLNQAGHSVTVFERADRAGGLLTYGIPNMKLEKGIVERRIKLLTQEGID FVTNTEIGVDITADELKEQFDAVILCTGAQKQRDLLIEGRDSKGVHYAMDYLTLATKS YLDSNFKDKQFIDAKGKDVIVIGGGDTGADCVATALRQKAKSVHQFGKHPKLPPARTN DNMWPEQPHVFTLEYAYEEAEAKFGRDPREYSIQTTKMVADKNGKLKELHTIQMEKVK NEHGKYEFRELPGTEKVWPAQLVFIAIGFEGTEQPLLKQFGVNSVNNKISAAYGDYQT NIDGVFAAGDARRGQSLIVWAINEGREVAREVDRYLMGSSVLP*" /label="gltB CDS" gene complement(1836052..1837533) /gene="gltB" /locus_tag="BSU_18440" /old_locus_tag="BSU18440" /label="gltB gene" downshifts complement(1836065) /Source="Nicolas_upshifts" /id="D1010" /incds=0 /nref=247 /ntot=279 /MaxReadThrough="3.292" /MaxDrop="7.52772" /score="10.4717228" /energy="-6.5" /TU="U1495" /idTUdmin="U1495" /TUdmin="-570" /isTUend="FALSE" /label="downshifts" CDS complement(1837550..1842112) /gene="gltA" /locus_tag="BSU_18450" /old_locus_tag="BSU18450" /EC_number="1.4.1.13" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:39113, 3011766, 6769440, 6774712, 7559359, 14570271, 17134717" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 39113, 3011766, 6769440, 6774712, 7559359, 14570271, 17134717; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate synthase (large subunit, NADP-dependent)" /protein_id="NP_389727.2" /db_xref="EnsemblGenomes-Gn:BSU18450" /db_xref="EnsemblGenomes-Tr:CAB13728" /db_xref="GOA:P39812" /db_xref="InterPro:IPR002489" /db_xref="InterPro:IPR002932" /db_xref="InterPro:IPR006982" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR017932" /db_xref="InterPro:IPR029055" /db_xref="InterPro:IPR036485" /db_xref="SubtiList:BG10811" /db_xref="UniProtKB/Swiss-Prot:P39812" /translation="MTYNQMPKAQGLYRPEFEHDACGIGLYAHLKGKQTHDIVKQGLK MLCQLDHRGGQGSDPDTGDGAGLLVQIPDAFFRKECKNINLPEKERYGVGMVFFSQKE DERKKIEKQINALIEQEGQVVLGWRTVPVNVGKIGTVAQKSCPFVRQVFIGASSDLKD NLSFERKLYVIRKQAENWGVTEGLDFYFASLSSQTIVYKGLLTPEQVDAFYSDLQDEA FVSAFALVHSRFSTNTFPTWERAHPNRYLVHNGEINTLRGNINWMRAREQQFVSESFG EDLNKILPILNADGSDSSILDNAFEFFVMAGRKPAHTAMMLIPEPWTENTHMSKEKRA FYEYHSSLMEPWDGPTAISFTDGKQIGAILDRNGLRPARYYVTKDDYIIFSSEVGVIE VEQENVLYKNRLEPGKMLLIDLEEGRIISDEEVKTQIATEYPYQKWLEEELVQVNPDP ESREEEQFSDLLTRQKAFGYTYEDIQKYLIPVIKEGKDPLGSMGNDAPLAVLSDRAQS LFNYFKQLFAQVTNPPIDAIREQLVTSTMTWLGAEGDLLHPSERNVRRIKLYTPVLSN EQFYALKTIVHPDLKSQKIDVLFSEDLERGLKDMFTQAEKAISQGVSLLILSDKKMNE RLTPIPPLLAVSALHQHLIRKGLRTKVSIIVESGEAREVHHFAALIGYGADAINPYLA YATYKQEIDEGRLDISYEEAVSKYGKSITEGVVKVMSKMGISTVQSYRGAQIFEAVGI SRDVIDRYFSGTASQLGGIDLQTIAEEAQRRHREAYQDDYSKTLEPGSDFQWRNGGEH HAFNPKTIHTLQWACRRNDYNLFKQYTKAADEERIGFLRNLFAFDGNRKPLKLEEVES AESIVKRFKTGAMSFGSLSKEAHEALAIAMNRLGGKSNSGEGGEDPKRFVPDENGDDR RSAIKQIASGRFGVKSHYLVNADELQIKMAQGAKPGEGGQLPGNKVYPWVADVRGSTP GVGLISPPPHHDIYSIEDLAQLIHDLKNANRDARISVKLVSKAGVGTIAAGVAKATAD VIVISGYDGGTGASPKTSIKHTGLPWELGLAEAHQTLMLNGLRDRVVLETDGKLMTGR DVVMAALLGAEEFGFATAPLVVLGCVMMRACHLDTCPVGVATQNPELRKKFMGDPDHI VNYMLFIAEEVREYMAALGFKTFDEMIGRTDVLHASERAKEHWKASQLDLSTLLYQPE GVRTFQSPQNHKIDQSLDITTILPAVQEAIESGKEADISIEINNTNRVAGTITGSEIS KRYGEEGLPEDTIKLHFTGSAGQSFGAFVPKGMTLYLDGDSNDYVGKGLSGGKIIVKS SEGFNSASDDNVIIGNVAFYGATSGEAYINGRAGERFAVRNSGVNVVVEGIGDHGCEY MTGGSVVVLGDVGKNFAAGMSGGIAYVLTEDVKAFKRKCNLEMILFESLEDEKEIQQI KAMLERHTAYTNSQKAEDLLDQWEDSVKKFVKVIPKNYKQMLASIEEQKAAGLSDEEA IMFAFEANTKPKQNTAASGQKQAVVQ*" /label="gltA CDS" gene complement(1837550..1842112) /gene="gltA" /locus_tag="BSU_18450" /old_locus_tag="BSU18450" /label="gltA gene" promotor_no_box 1840573..1840673 /Source="Nicolas_upshift_promotors" /id="U1494" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.974025974025974" /psig="0.001998001998002" /xcortree=23 /SigmaFactorBS="taaagtagttaaacagcgattgcgctcggtcagaaagtacag caagcggagcgtcattccccattgaaccaaggggatctttgccttctttaataacagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 1840633 /Source="Nicolas_upshifts" /id="U1494" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.974025974025974" /psig="0.001998001998002" /xcortree=23 /SigmaFactorBS="taaagtagttaaacagcgattgcgctcggtcagaaagtacag caagcggagcgtcattccccattgaaccaaggggatctttgccttctttaataacagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1842113..1842184) /Source="Nicolas_S_feature" /locus_tag="new_2014633_2014704_c" /HighExp="SMM, T-5.40H, HiOs, MG 15, Glu, T-4.40H, MG 150, MG 60, UNK1, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S683" promotor_-10 complement(1842164..1842183) /Source="Nicolas_upshift_promotors" /id="U1495" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=3025 /SigmaFactorBS="catctatctcattttgagattcttttgatctaaattataTAT TGTTTatatcgttttgaaaACCTACAATGATTATAGAGTtgttagattttatgaccgg t" /listShort="S683, gltA, gltB, S682" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 1842181..1842188 /Source="Nicolas_upshift_promotors" /id="U1496" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.727272727272727" /psig="0.966033966033966" /xcortree=2238 /SigmaFactorBS="taataccggtcataaaatctaacaactctataatcattgtaG GTTTTCAaaacgatataaacaATATATAATTTAGATCAAAAgaatctcaaaatgagat a" /listShort="gltC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1842184) /Source="Nicolas_upshifts" /id="U1495" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=3025 /SigmaFactorBS="catctatctcattttgagattcttttgatctaaattataTAT TGTTTatatcgttttgaaaACCTACAATGATTATAGAGTtgttagattttatgaccgg t" /listShort="S683, gltA, gltB, S682" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1842198..1842205) /Source="Nicolas_upshift_promotors" /id="U1495" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=3025 /SigmaFactorBS="catctatctcattttgagattcttttgatctaaattataTAT TGTTTatatcgttttgaaaACCTACAATGATTATAGAGTtgttagattttatgaccgg t" /listShort="S683, gltA, gltB, S682" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1842200 /Source="Nicolas_upshifts" /id="U1496" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.727272727272727" /psig="0.966033966033966" /xcortree=2238 /SigmaFactorBS="taataccggtcataaaatctaacaactctataatcattgtaG GTTTTCAaaacgatataaacaATATATAATTTAGATCAAAAgaatctcaaaatgagat a" /listShort="gltC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1842203..1842222 /Source="Nicolas_upshift_promotors" /id="U1496" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.727272727272727" /psig="0.966033966033966" /xcortree=2238 /SigmaFactorBS="taataccggtcataaaatctaacaactctataatcattgtaG GTTTTCAaaacgatataaacaATATATAATTTAGATCAAAAgaatctcaaaatgagat a" /listShort="gltC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1842259..1843161 /gene="gltC" /locus_tag="BSU_18460" /old_locus_tag="BSU18460" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:2548995, 15150225, 17134717, 28294562" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2548995, 15150225, 17134717, 28294562; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (LysR family) (GltC-glutamate)" /protein_id="NP_389728.2" /db_xref="EnsemblGenomes-Gn:BSU18460" /db_xref="EnsemblGenomes-Tr:CAB13729" /db_xref="GOA:P20668" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10810" /db_xref="UniProtKB/Swiss-Prot:P20668" /translation="MELRQLRYFMEVAEREHVSEAADHLHVAQSAISRQIANLEEELN VTLFEREGRNIKLTPIGKEFLIHVKTAMKAIDYAKEQIDEYLDPHRGTVKIGFPTSLA SQLLPTVISAFKEEYPHVEFLLRQGSYKFLIEAVRNRDIDLALLGPVPTNFSDITGKI LFTEKIYALVPLNHPLAKQKTVHLIDLRNDQFVLFPEGFVLREMAIDTCKQAGFAPLV STEGEDLDAIKGLVSAGMGVTLLPESTFAETTPRFTVKIPIEFPQVKRTVGIIKPKNR ELAPSANDFYEFVIQFFSKLEQYQ*" /label="gltC CDS" gene 1842259..1843161 /gene="gltC" /locus_tag="BSU_18460" /old_locus_tag="BSU18460" /label="gltC gene" downshifts 1843141 /Source="Nicolas_upshifts" /id="D1011" /incds=0 /nref=104 /ntot=241 /MaxReadThrough="2.84467" /MaxDrop="3.98111" /score="22.3639229" /energy="-13.6" /TU="NA" /idTUdmin="U1496" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1843213..1844328) /gene="proJ" /locus_tag="BSU_18470" /old_locus_tag="BSU18470" /EC_number="2.7.2.11" /function="16.8: Protect" /function="16.14: Store" /experiment="publication(s) with functional evidences, PMID:11418582, 15804359, 21784929, 28752945" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418582, 15804359, 21784929, 28752945; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate 5-kinase" /protein_id="NP_389729.1" /db_xref="EnsemblGenomes-Gn:BSU18470" /db_xref="EnsemblGenomes-Tr:CAB13740" /db_xref="GOA:O07509" /db_xref="InterPro:IPR001048" /db_xref="InterPro:IPR001057" /db_xref="InterPro:IPR002478" /db_xref="InterPro:IPR005715" /db_xref="InterPro:IPR011529" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR019797" /db_xref="InterPro:IPR036393" /db_xref="InterPro:IPR036974" /db_xref="SubtiList:BG12658" /db_xref="UniProtKB/Swiss-Prot:O07509" /translation="MTPDTSMKRVVVKIGSSSLTSLHGEISIRKLEALVDQVVKLKDA GYEVILVSSGAVAAGYRKLGFIQRPEKLPEKQASASIGQGLLMEAYSKLFLAHGYVAS QILITRSDFSDEYRYNNVRNTMNVLLERGIIPIINENDTVTVNRLKFGDNDTLAAKVA GLIDADMLVILSDIDGLYDGNPRTNPEAKKIQRVSEITPDIEACAGDTGSIVGTGGMR SKLDAFKIVMASGIKGFLGQADAGDILYHAVHEQAEGTYFEAEGTLPLNQKEQWIAFN SGPEGEMILSDDCSRKITNGQSSLYLDGVQKIKGKFKSGSVVRLMDSKGTEIGLGIVN YSSVQLQEPEKKKELTNRALIDQEAFVCHVDFSLPVN*" /label="proJ CDS" gene complement(1843213..1844328) /gene="proJ" /locus_tag="BSU_18470" /old_locus_tag="BSU18470" /label="proJ gene" CDS complement(1844325..1845218) /gene="proH" /locus_tag="BSU_18480" /old_locus_tag="BSU18480" /EC_number="1.5.1.2" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11418582, 21784929, 22139509, 25344233, 28752945" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418582, 21784929, 22139509, 25344233, 28752945; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyrroline-5-carboxylate reductase" /protein_id="NP_389730.2" /db_xref="EnsemblGenomes-Gn:BSU18480" /db_xref="EnsemblGenomes-Tr:CAB13741" /db_xref="GOA:P0CI77" /db_xref="InterPro:IPR000304" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR028939" /db_xref="InterPro:IPR029036" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11049" /db_xref="UniProtKB/Swiss-Prot:P0CI77" /translation="MRTKKRTKEMLPIFDQKKVAFIGAGSMAEGMISGIVRANKIPKQ NICVTNRSNTERLTELELQYGIKGALPNQLCIEDMDVLILAMKPKDAENALSSLKSRI QPHQLILSVLAGITTSFIEQSLLNEQPVVRVMPNTSSMIGASATAIALGKYVSEDLKK LAEALLGCMGEVYTIQENQMDIFTGIAGSGPAYFYYLMEFIEKTGEEAGLDKQLSRSI GAQTLLGAAKMLMETGEHPEILRDNITSPNGTTAAGLQALKKSGGGEAISQAIKHAAK RSKEISEDIEKTAAPLSGVIK*" /label="proH CDS" gene complement(1844325..1845218) /gene="proH" /locus_tag="BSU_18480" /old_locus_tag="BSU18480" /label="proH gene" promotor_-10 complement(1845223..1845242) /Source="Nicolas_upshift_promotors" /id="U1497" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=3035 /SigmaFactorBS="gtcgaaaagaaacaatacaaatcaataatggccttcaaaCTT GACAtcatttcctcacgTGGTAACATTTTAAACGTGTgaaaatgcgaacaaaaaagcg a" /listShort="proH, proJ" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 1845231 /Source="Nicolas_upshifts" /id="D1012" /incds=0 /nref=1 /ntot=6 /MaxReadThrough="1.17009" /MaxDrop="3.27004" /score="-0.988973561" /energy="-13.3" /TU="NA" /idTUdmin="U1496" /TUdmin=2090 /isTUend="FALSE" /label="downshifts" upshifts complement(1845241) /Source="Nicolas_upshifts" /id="U1497" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=3035 /SigmaFactorBS="gtcgaaaagaaacaatacaaatcaataatggccttcaaaCTT GACAtcatttcctcacgTGGTAACATTTTAAACGTGTgaaaatgcgaacaaaaaagcg a" /listShort="proH, proJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1845256..1845262) /Source="Nicolas_upshift_promotors" /id="U1497" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=3035 /SigmaFactorBS="gtcgaaaagaaacaatacaaatcaataatggccttcaaaCTT GACAtcatttcctcacgTGGTAACATTTTAAACGTGTgaaaatgcgaacaaaaaagcg a" /listShort="proH, proJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1845271..1845289) /Source="Nicolas_upshift_promotors" /id="U1498" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1173 /SigmaFactorBS="gcgcagcagtgtgaaccgggtgttttctgcttttcattaTAC ATAtttgtcgaaaagaaaCAATACAAATCAATAATGGccttcaaacttgacatcattt c" /listShort="proH, proJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1845289) /Source="Nicolas_upshifts" /id="U1498" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1173 /SigmaFactorBS="gcgcagcagtgtgaaccgggtgttttctgcttttcattaTAC ATAtttgtcgaaaagaaaCAATACAAATCAATAATGGccttcaaacttgacatcattt c" /listShort="proH, proJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1845305..1845310) /Source="Nicolas_upshift_promotors" /id="U1498" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1173 /SigmaFactorBS="gcgcagcagtgtgaaccgggtgttttctgcttttcattaTAC ATAtttgtcgaaaagaaaCAATACAAATCAATAATGGccttcaaacttgacatcattt c" /listShort="proH, proJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1845366..1845734) /gene="rtp" /locus_tag="BSU_18490" /old_locus_tag="BSU18490" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:11313334, 15657033, 16822523, 17376071, 17521668, 24946150" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11313334, 15657033, 16822523, 17376071, 17521668, 24946150; Product type f : factor" /codon_start=1 /transl_table=11 /product="replication terminator protein" /protein_id="NP_389731.1" /db_xref="EnsemblGenomes-Gn:BSU18490" /db_xref="EnsemblGenomes-Tr:CAB13742" /db_xref="GOA:P0CI76" /db_xref="InterPro:IPR003432" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:1BM9" /db_xref="PDB:1F4K" /db_xref="PDB:1J0R" /db_xref="PDB:2DPD" /db_xref="PDB:2DPU" /db_xref="PDB:2DQR" /db_xref="PDB:2EFW" /db_xref="SubtiList:BG10738" /db_xref="UniProtKB/Swiss-Prot:P0CI76" /translation="MKEEKRSSTGFLVKQRAFLKLYMITMTEQERLYGLKLLEVLRSE FKEIGFKPNHTEVYRSLHELLDDGILKQIKVKKEGAKLQEVVLYQFKDYEAAKLYKKQ LKVELDRCKKLIEKALSDNF*" /label="rtp CDS" gene complement(1845366..1845734) /gene="rtp" /locus_tag="BSU_18490" /old_locus_tag="BSU18490" /label="rtp gene" promotor_-10 complement(1845769..1845787) /Source="Nicolas_upshift_promotors" /id="U1499" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=3198 /SigmaFactorBS="aatcagtaaacatgaaataactggactatcagtctttaatat aaaGAAGGAAAAcaataaaagaaAATTGAATATTTAGTACATagtgttgtcagtgaca g" /listShort="rtp" /listLong="proH" /label="promotor_-10" upshifts complement(1845792) /Source="Nicolas_upshifts" /id="U1499" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=3198 /SigmaFactorBS="aatcagtaaacatgaaataactggactatcagtctttaatat aaaGAAGGAAAAcaataaaagaaAATTGAATATTTAGTACATagtgttgtcagtgaca g" /listShort="rtp" /listLong="proH" /label="upshifts" S_feature complement(1845794..1845913) /Source="Nicolas_S_feature" /locus_tag="new_2018314_2018433_c" /HighExp="dia15, Etha, dia5, Diami, H2O2, LBGtran, LoTm, LBGexp, G180, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S684" promotor_-35 complement(1845799..1845807) /Source="Nicolas_upshift_promotors" /id="U1499" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=3198 /SigmaFactorBS="aatcagtaaacatgaaataactggactatcagtctttaatat aaaGAAGGAAAAcaataaaagaaAATTGAATATTTAGTACATagtgttgtcagtgaca g" /listShort="rtp" /listLong="proH" /label="promotor_-35" promotor_-10 complement(1845905..1845924) /Source="Nicolas_upshift_promotors" /id="U1500" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2054 /SigmaFactorBS="gagatatgtaaaccctggcaatcgtttAAATTGAAgatagca gtaaatgCAGGCTATAATAGAACTAAGaaaactatgtaccaaatgttcagtcgaaatt t" /listShort="S684, rtp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1845913) /Source="Nicolas_upshifts" /id="U1500" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2054 /SigmaFactorBS="gagatatgtaaaccctggcaatcgtttAAATTGAAgatagca gtaaatgCAGGCTATAATAGAACTAAGaaaactatgtaccaaatgttcagtcgaaatt t" /listShort="S684, rtp" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1845915..1846011) /Source="Nicolas_S_feature" /locus_tag="new_2018435_2018531_c" /HighExp="Etha, dia15, LBGtran, LoTm, dia5, H2O2, LBGexp, M0t45, G135, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S685" promotor_-35 complement(1845939..1845946) /Source="Nicolas_upshift_promotors" /id="U1500" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2054 /SigmaFactorBS="gagatatgtaaaccctggcaatcgtttAAATTGAAgatagca gtaaatgCAGGCTATAATAGAACTAAGaaaactatgtaccaaatgttcagtcgaaatt t" /listShort="S684, rtp" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1846034..1846750) /gene="yoxD" /locus_tag="BSU_18500" /old_locus_tag="BSU18500" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15317791; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxido-reductase" /protein_id="NP_389732.1" /db_xref="EnsemblGenomes-Gn:BSU18500" /db_xref="EnsemblGenomes-Tr:CAB13743" /db_xref="GOA:P14802" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11048" /db_xref="UniProtKB/Swiss-Prot:P14802" /translation="MQSLQHKTALITGGGRGIGRATALALAKEGVNIGLIGRTSANVE KVAEEVKALGVKAAFAAADVKDADQVNQAVAQVKEQLGDIDILINNAGISKFGGFLDL SADEWENIIQVNLMGVYHVTRAVLPEMIERKAGDIINISSTAGQRGAAVTSAYSASKF AVLGLTESLMQEVRKHNIRVSALTPSTVASDMSIELNLTDGNPEKVMQPEDLAEYMVA QLKLDPRIFIKTAGLWSTNP*" /label="yoxD CDS" gene complement(1846034..1846750) /gene="yoxD" /locus_tag="BSU_18500" /old_locus_tag="BSU18500" /label="yoxD gene" downshifts complement(1846056) /Source="Nicolas_upshifts" /id="D1013" /incds=0 /nref=109 /ntot=217 /MaxReadThrough="4.9568" /MaxDrop="5.08605" /score="27.1231718" /energy="-7.5" /TU="U1501" /idTUdmin="U1500" /TUdmin="-594" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1846788..1846807) /Source="Nicolas_upshift_promotors" /id="U1501" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.772227772227772" /psig="0.996003996003996" /xcortree=2690 /SigmaFactorBS="ttaatcagaagaaatgatatttacacagttcGTTTgatttgc gtattggaTGTATTGTACTTATAATGTGatatcgtacatatgtaaacaaagaaagggt g" /listShort="yoxD, S685, S684, rtp, proH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1846797) /Source="Nicolas_upshifts" /id="U1501" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.772227772227772" /psig="0.996003996003996" /xcortree=2690 /SigmaFactorBS="ttaatcagaagaaatgatatttacacagttcGTTTgatttgc gtattggaTGTATTGTACTTATAATGTGatatcgtacatatgtaaacaaagaaagggt g" /listShort="yoxD, S685, S684, rtp, proH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1846823..1846826) /Source="Nicolas_upshift_promotors" /id="U1501" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.772227772227772" /psig="0.996003996003996" /xcortree=2690 /SigmaFactorBS="ttaatcagaagaaatgatatttacacagttcGTTTgatttgc gtattggaTGTATTGTACTTATAATGTGatatcgtacatatgtaaacaaagaaagggt g" /listShort="yoxD, S685, S684, rtp, proH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1846851..1846857 /Source="Nicolas_upshift_promotors" /id="U1502" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=228 /SigmaFactorBS="gcaaatcaaacgaactgtgtaaatatcatttcttcTGATTAA aaaaacggatacaGGGTAATGACATAAGAAAAggagtgaacatatgattatagtttat a" /listShort="yoxC, yoxB, yoaA, S686, S687" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1846871..1846889 /Source="Nicolas_upshift_promotors" /id="U1502" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=228 /SigmaFactorBS="gcaaatcaaacgaactgtgtaaatatcatttcttcTGATTAA aaaaacggatacaGGGTAATGACATAAGAAAAggagtgaacatatgattatagtttat a" /listShort="yoxC, yoxB, yoaA, S686, S687" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1846876 /Source="Nicolas_upshifts" /id="U1502" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=228 /SigmaFactorBS="gcaaatcaaacgaactgtgtaaatatcatttcttcTGATTAA aaaaacggatacaGGGTAATGACATAAGAAAAggagtgaacatatgattatagtttat a" /listShort="yoxC, yoxB, yoaA, S686, S687" /GFF_Attribute="listLong" /label="upshifts" CDS 1846901..1847206 /gene="yoxC" /locus_tag="BSU_18510" /old_locus_tag="BSU18510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16513748, 17598888; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="transition-dependent and sulfur-related metabolism protein" /protein_id="NP_389733.1" /db_xref="EnsemblGenomes-Gn:BSU18510" /db_xref="EnsemblGenomes-Tr:CAB13744" /db_xref="InterPro:IPR009293" /db_xref="SubtiList:BG11047" /db_xref="UniProtKB/Swiss-Prot:P28670" /translation="MIIVYISLAVLAVSIIFLGVTVIQNKKKIDPALKELSSVTQAMQ KQIEGLKTETELLTQKQKKIQQDVQIKKYTLQQTAAEVKEVPQAVKEVWQAGHFNSR* " /label="yoxC CDS" gene 1846901..1847206 /gene="yoxC" /locus_tag="BSU_18510" /old_locus_tag="BSU18510" /label="yoxC gene" downshifts 1847190 /Source="Nicolas_upshifts" /id="D1014" /incds=0 /nref=6 /ntot=88 /MaxReadThrough="5.31272" /MaxDrop="3.8396" /score="-9.7711365" /energy="-17.8" /TU="U1502" /idTUdmin="U1503" /TUdmin="-1473" /isTUend="FALSE" /label="downshifts" CDS 1847277..1848047 /gene="yoxB" /locus_tag="BSU_18520" /old_locus_tag="BSU18520" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11717291, 17598888, 19703276" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389734.1" /db_xref="EnsemblGenomes-Gn:BSU18520" /db_xref="EnsemblGenomes-Tr:CAB13745" /db_xref="InterPro:IPR020530" /db_xref="InterPro:IPR036895" /db_xref="SubtiList:BG11046" /db_xref="UniProtKB/Swiss-Prot:P28671" /translation="MIINRSCLKEFAEKVHFLPSSLTKSDLLTDPFRLHQENELGIYY SPHNEFINRDASLVIAGITPGFSQMKTAYETAAESLLQGGTLEQMAVDTKIAAGFSGS MRHNLITMLDLCGLPQAFGIQSAAKLFGELRHMLHTTSVIKYPVFIQQKNYTGYKPAI THSPILSTYAFGHFPAELNHVTGPALLIPLGKAAETVCETLIRQHSLQNLICLNGFPH PSGANGHRLKQFSKNKEQLERQIRSFAALVDFAIEKRK*" /label="yoxB CDS" gene 1847277..1848047 /gene="yoxB" /locus_tag="BSU_18520" /old_locus_tag="BSU18520" /label="yoxB gene" promotor_-35 1848029..1848036 /Source="Nicolas_upshift_promotors" /id="U1503" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.889110889110889" /psig="0.996003996003996" /xcortree=560 /SigmaFactorBS="gaaagacaaattcgttcctttgctgcattggttgatttcgcT ATAGAAAagaggaaataaaagGGATATGATAAACAAAAACAcaaacgtggggagtggt t" /listShort="yoaA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1848048 /Source="Nicolas_upshifts" /id="U1503" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.889110889110889" /psig="0.996003996003996" /xcortree=560 /SigmaFactorBS="gaaagacaaattcgttcctttgctgcattggttgatttcgcT ATAGAAAagaggaaataaaagGGATATGATAAACAAAAACAcaaacgtggggagtggt t" /listShort="yoaA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1848051..1848070 /Source="Nicolas_upshift_promotors" /id="U1503" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.889110889110889" /psig="0.996003996003996" /xcortree=560 /SigmaFactorBS="gaaagacaaattcgttcctttgctgcattggttgatttcgcT ATAGAAAagaggaaataaaagGGATATGATAAACAAAAACAcaaacgtggggagtggt t" /listShort="yoaA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1848091..1848624 /gene="yoaA" /locus_tag="BSU_18530" /old_locus_tag="BSU18530" /EC_number="2.3.1.-" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10482513, 11717291, 17598888; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_389735.2" /db_xref="EnsemblGenomes-Gn:BSU18530" /db_xref="EnsemblGenomes-Tr:CAB13746" /db_xref="GOA:O34569" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13472" /db_xref="UniProtKB/Swiss-Prot:O34569" /translation="MFPILETDRLILRQITDQDAEAIFACFSNDEVTRYYGLENMESI EQAISMIQTFAALYQEKRGIRWGIERRDTKELIGTIGFHALAQKHRRAEIGYEIIPEH WRNGFASEVISKVVSYGFSALGLSRIGAVVFTDNEASNRLLLKMGFQKEGVLRQYMYQ NGTPYDTNVYSIVKPRE*" /label="yoaA CDS" gene 1848091..1848624 /gene="yoaA" /locus_tag="BSU_18530" /old_locus_tag="BSU18530" /label="yoaA gene" S_feature 1848625..1848710 /Source="Nicolas_S_feature" /locus_tag="new_2021145_2021230" /HighExp="Salt, Sw, B60, LoTm, B36, M9-stat, BC, Lbstat, HiTm, Etha" /AntisenseName="yoaB" /AntisenseCor="-0.17521117067018899" /AntisenseRegPval="-2.4" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S686" downshifts 1848667 /Source="Nicolas_upshifts" /id="D1015" /incds=0 /nref=6 /ntot=100 /MaxReadThrough="4.32682" /MaxDrop="3.67936" /score="-9.7711365" /energy="-17.8" /TU="U1502" /idTUdmin="U1503" /TUdmin=4 /isTUend="TRUE" /label="downshifts" CDS complement(1848703..1849947) /gene="yoaB" /locus_tag="BSU_18540" /old_locus_tag="BSU18540" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12193636, 15849754, 16513748, 16850406, 28546427; Product type t : transporter" /codon_start=1 /transl_table=11 /product="negatively charged metabolite transporter" /protein_id="NP_389736.1" /db_xref="EnsemblGenomes-Gn:BSU18540" /db_xref="EnsemblGenomes-Tr:CAB13747" /db_xref="GOA:O34864" /db_xref="InterPro:IPR004748" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13473" /db_xref="UniProtKB/Swiss-Prot:O34864" /translation="MLDKIGIPKRLAWGFLGVVLFMMGDGLEQGWLSPFLIENGLTVQ QSASIFSIYGIALAIASWFSGVCLEAFGAKRTMFMGLLFYVIGTAAFIVFGFEQLNLP VMYVTYFVKGLGYPLFAYSFLTWVIYRTPQSKLSTAVGWFWIAYCLGMFVFGAWYSSY AIKAFGYLNTLWSSIFWVCLGAFFALFINKDRFEKKKRKRSETAEELLKGVTILFTNP RVLTGGIIRIINSIGTYGFPVFLPMHMAQHGISTNVWLQIWGTIFLGNIVFNLIFGIV GDKFGWKNTVIWFGGVGCGIFTVLLYYAPVFSGGSLAVVSVIGFIWGGLLAGYVPIGA IVPTVAGKDKGAAMSVLNLAAGLSAFVGPALAWLFIGLVGAQGVVWIFAALYLASAVL TKCIHIPEEKAVKEETSPQYAS*" /label="yoaB CDS" gene complement(1848703..1849947) /gene="yoaB" /locus_tag="BSU_18540" /old_locus_tag="BSU18540" /label="yoaB gene" S_feature 1848712..1849451 /Source="Nicolas_S_feature" /locus_tag="new_2021232_2021971" /HighExp="LoTm, Salt, Sw, S6, Etha, M9-stat, LPhT, B60, T2.0H, T2.30H" /AntisenseName="yoaB" /AntisenseCor="-0.18536963552729299" /AntisenseRegPval="-2.6" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S687" downshifts complement(1848717) /Source="Nicolas_upshifts" /id="D1016" /incds=0 /nref=32 /ntot=113 /MaxReadThrough="2.59019" /MaxDrop="4.97477" /score="29.0246554" /energy="-12.5" /TU="NA" /idTUdmin="U1504" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1849948..1850040) /Source="Nicolas_S_feature" /locus_tag="new_2022468_2022560_c" /HighExp="MG 10, MG 5, BMM, MG t5, MG 15, GM 25, HiTm, UNK1, GM 15, Gly" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S688" CDS complement(1850041..1851504) /gene="yoaC" /locus_tag="BSU_18550" /old_locus_tag="BSU18550" /EC_number="2.7.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 10094622, 12193636, 16850406, 18039762, 21749987, 27795321, 28546427; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="hydroxylated metabolite kinase" /protein_id="NP_389737.1" /db_xref="EnsemblGenomes-Gn:BSU18550" /db_xref="EnsemblGenomes-Tr:CAB13748" /db_xref="GOA:O34861" /db_xref="InterPro:IPR000577" /db_xref="InterPro:IPR018484" /db_xref="InterPro:IPR018485" /db_xref="SubtiList:BG13474" /db_xref="UniProtKB/Swiss-Prot:O34861" /translation="MKKQKGYLVFDIGTGNARVAVVSVTGSVLTVEREDIEYSTETLY PDSRYFSPQVLWKQVMNLAKRALSRSCDIDIIGLTSTSQRQGIVLIDQNGNPFLGLPN IDNRGREWEAGIPDWEEIYSSTGRLPTALFSALKLYGLKQRQPSLWEKTASFTSISDW VTYQLSGILTYEPSQATETLLFDVKQNTWSEEMCDIFGFSPSILPPLVRAGTAIGTIA NEYASELGLSINAKVIAGGGDTQLAVKSTGAGLEDIVIVSGTTTPITKITEDHGDTKH KAWLNCHTDQGHWLVETNPGITGLNYQKLKQIFYPNETYEVMEEEISALAKEDHACVA ALGSYLSAEKNALTRGGFLFDAPLSAHLKRAHFVRAALEEIAFSIKWNFDILTEVTPF ERDYVWVCGGGFQSKALTQYIADLLQKKVYVQEGYHQASVVGAAVICNETFQLTEEMS ANVRVIEPKDCQIELALYEEWKQTQRFFSGSESKVLI*" /label="yoaC CDS" gene complement(1850041..1851504) /gene="yoaC" /locus_tag="BSU_18550" /old_locus_tag="BSU18550" /label="yoaC gene" CDS complement(1851522..1852556) /gene="yoaD" /locus_tag="BSU_18560" /old_locus_tag="BSU18560" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10094622, 11390694, 12193636, 17012385, 18039762, 21749987, 27795321; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 2-hydroxyacid dehydrogenase" /protein_id="NP_389738.1" /db_xref="EnsemblGenomes-Gn:BSU18560" /db_xref="EnsemblGenomes-Tr:CAB13749" /db_xref="GOA:O34815" /db_xref="InterPro:IPR006139" /db_xref="InterPro:IPR006140" /db_xref="InterPro:IPR029753" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13475" /db_xref="UniProtKB/Swiss-Prot:O34815" /translation="MKNTMKRMFCSMTVLVTAPYNEEGRKELENLFGSVAYQSWKEQG RAYREDELIQLLKATNATGLITELDQVTDSVFASVPELSFVGVCRGMPSNVDVAAASK RGIPVFYTPGRNAQAVAEMFIGNVISFLRHTSASNQWLKDGEWDSDYLQAYVKFKGNE LTGKTVGMIGFGAVGQRIAKLLTAFDCKIKYYDPYIQDDHPLYEKASLKTVFSDSDIV SVHLPRTEETLGLIDRQYFDLMKESAIFVNTSRAVVVNREDLLFVLKEHKISGAILDV FYHEPPEESDYELISLPNVLATPHLAGATFEVEDHHVTILNKALKKWKGEKTLNIQTM YNKDALKTGG*" /label="yoaD CDS" gene complement(1851522..1852556) /gene="yoaD" /locus_tag="BSU_18560" /old_locus_tag="BSU18560" /label="yoaD gene" S_feature complement(1852568..1852639) /Source="Nicolas_S_feature" /locus_tag="new_2025088_2025159_c" /HighExp="MG t5, MG 5, MG 10, BMM, GM 25, MG 15, Heat, GM 15, MG-0.2, M9-exp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S689" downshifts complement(1852611) /Source="Nicolas_upshifts" /id="D1017" /incds=0 /nref=1 /ntot=24 /MaxReadThrough="7.78218" /MaxDrop="4.81701" /score="26.3160061" /energy="-11.4" /TU="U1504" /idTUdmin="U1507" /TUdmin=2727 /isTUend="FALSE" /label="downshifts" misc_RNA complement(1852640..1852731) /gene="mswF" /locus_tag="BSU_misc_RNA_31" /product="AdoMet riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /function="16.3: Control" /label="mswF RNA" gene complement(1852640..1852731) /gene="mswF" /locus_tag="BSU_misc_RNA_31" /label="mswF gene" promotor_-10 complement(1852759..1852778) /Source="Nicolas_upshift_promotors" /id="U1504" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2890 /SigmaFactorBS="tccgatgataacgtcaattctgaaaaaaagaGATTGACAtca atctgagtcttCTTTATGATAAACGTATTCTtcattctgaaaattacatactcaatat t" /listShort="NA, S689, yoaD, yoaC, S688, yoaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1852771) /Source="Nicolas_upshifts" /id="U1504" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2890 /SigmaFactorBS="tccgatgataacgtcaattctgaaaaaaagaGATTGACAtca atctgagtcttCTTTATGATAAACGTATTCTtcattctgaaaattacatactcaatat t" /listShort="NA, S689, yoaD, yoaC, S688, yoaB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1852793..1852800) /Source="Nicolas_upshift_promotors" /id="U1504" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2890 /SigmaFactorBS="tccgatgataacgtcaattctgaaaaaaagaGATTGACAtca atctgagtcttCTTTATGATAAACGTATTCTtcattctgaaaattacatactcaatat t" /listShort="NA, S689, yoaD, yoaC, S688, yoaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1852813..1852820 /Source="Nicolas_upshift_promotors" /id="U1505" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=3069 /SigmaFactorBS="gaagactcagattgatgtcaatctctttttttcagAATTGAC GttatcatcggaaaTGTTATAATTCTTACAAAATatctaactagagagaggaactggg c" /listShort="yoaE, yoaF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1852834..1852853 /Source="Nicolas_upshift_promotors" /id="U1505" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=3069 /SigmaFactorBS="gaagactcagattgatgtcaatctctttttttcagAATTGAC GttatcatcggaaaTGTTATAATTCTTACAAAATatctaactagagagaggaactggg c" /listShort="yoaE, yoaF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1852838 /Source="Nicolas_upshifts" /id="U1505" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=3069 /SigmaFactorBS="gaagactcagattgatgtcaatctctttttttcagAATTGAC GttatcatcggaaaTGTTATAATTCTTACAAAATatctaactagagagaggaactggg c" /listShort="yoaE, yoaF" /GFF_Attribute="listLong" /label="upshifts" CDS 1852880..1854922 /gene="yoaE" /locus_tag="BSU_18570" /old_locus_tag="BSU18570" /EC_number="1.-.-.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 2170332, 17114254; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="molybdopterin cofactor oxido-reductase" /protein_id="NP_389739.2" /db_xref="EnsemblGenomes-Gn:BSU18570" /db_xref="EnsemblGenomes-Tr:CAB13750" /db_xref="GOA:C0SP82" /db_xref="InterPro:IPR006655" /db_xref="InterPro:IPR006656" /db_xref="InterPro:IPR006657" /db_xref="InterPro:IPR006963" /db_xref="InterPro:IPR009010" /db_xref="SubtiList:BG13476" /db_xref="UniProtKB/Swiss-Prot:C0SP82" /translation="MRSFATQQNGIFKSVCSLDCPDQCGLLIHKKDGKIVKVQGDPDH PVTAGNICNKVRNMTERIYDEKRLTTPLKRTGAKGQAIFEPISWKEAIDTITSRWKQL IDEEGAESILPYSFYGNMGKLTAEGMDRRFFYRMGSSQLERTICSKAGSEGYKYTMGI SAGIDPEETVHTKLFIFWGINAVSTNMHQITIAQKARKKGAKIVVIDVHKNQTGRLAD WFIPIKPGTDSALALGIMHILFKENLHDEAFLSEYTVGYEELREHVKQYDPEKVSTIT GVSTEDIYRLAKMYGETSPSFIRIGNGPQHHDNGGMIVRTIACLPAITGQWLHTGGGA IKHNSGILEYNTNALQRPDLLKGRTPRSFNMNQLGRVLLETDPPIRSLFIYGTNPAVV APEANKVRQGLLREDLFTVVHDLFLTETAAYADIVLPATSAFENTDFYTSYWHHYIQL QQPVIERYGESKSNTEVFRLLAEAMGFTDQELKDSDEVLIRQALDHPDNPHLAEIDYD SLTKHSFMKAKREKPLFPGELPTPSGKIELYSEKMKQDGFPALPTYTPLVTDNEHPFM YVPGPNHNFLNSTFSNNEKHIKLEKTPKLFINTKDAEKHGIVDGAPVRIWNSRGECEL TAAVGEQVLPGVVVSQGLWADEQGKKQLVNALTPDRLSDMGGGATFFSGRVQIEKV*" /label="yoaE CDS" gene 1852880..1854922 /gene="yoaE" /locus_tag="BSU_18570" /old_locus_tag="BSU18570" /label="yoaE gene" promotor_-35 1854930..1854939 /Source="Nicolas_upshift_promotors" /id="U1506" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1664 /SigmaFactorBS="aggccgtgtacagattgaaaaggtttgaaaaataaTGAAACC CGGagtatgccaagcCCGTATAACATAACATcgacataatggaggcatacacatggac g" /listShort="yoaF, S692, yozQ, S693" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1854952..1854967 /Source="Nicolas_upshift_promotors" /id="U1506" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1664 /SigmaFactorBS="aggccgtgtacagattgaaaaggtttgaaaaataaTGAAACC CGGagtatgccaagcCCGTATAACATAACATcgacataatggaggcatacacatggac g" /listShort="yoaF, S692, yozQ, S693" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1854955 /Source="Nicolas_upshifts" /id="U1506" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1664 /SigmaFactorBS="aggccgtgtacagattgaaaaggtttgaaaaataaTGAAACC CGGagtatgccaagcCCGTATAACATAACATcgacataatggaggcatacacatggac g" /listShort="yoaF, S692, yozQ, S693" /GFF_Attribute="listLong" /label="upshifts" CDS 1854989..1855282 /gene="yoaF" /locus_tag="BSU_18580" /old_locus_tag="BSU18580" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 23155385" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389740.1" /db_xref="EnsemblGenomes-Gn:BSU18580" /db_xref="EnsemblGenomes-Tr:CAB13751" /db_xref="SubtiList:BG13477" /db_xref="UniProtKB/Swiss-Prot:O31829" /translation="MDVFLGIGIALAGYFIGEGLKQRNQTKGNEQNDIFLIKERDIYF YIGLFLGITTTEAKQLAGDMADLPYIEINGKKYVQKHMLKDWTFTLVEKHQGE*" /label="yoaF CDS" gene 1854989..1855282 /gene="yoaF" /locus_tag="BSU_18580" /old_locus_tag="BSU18580" /label="yoaF gene" downshifts 1855262 /Source="Nicolas_upshifts" /id="D1018" /incds=0 /nref=97 /ntot=243 /MaxReadThrough="3.40762" /MaxDrop="4.1662" /score="-6.27063114" /energy="-3.9" /TU="U1506" /idTUdmin="U1505" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1855307..1855654) /Source="Nicolas_S_feature" /locus_tag="new_2027827_2028174_c" /HighExp="T0.30H, S0, T1.0H, aero, Etha, S8, SMMPr, T-0.40H, ferm, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S690" downshifts complement(1855338) /Source="Nicolas_upshifts" /id="D1019" /incds=0 /nref=43 /ntot=202 /MaxReadThrough="2.3171" /MaxDrop="4.25059" /score="-6.12586993" /energy="-17.4" /TU="NA" /idTUdmin="U1507" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1855655..1856059) /gene="yoaG" /locus_tag="BSU_18590" /old_locus_tag="BSU18590" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14563871, 15849754, 16850406, 20011599, 23155385; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative phage-related membrane protein" /protein_id="NP_389741.1" /db_xref="EnsemblGenomes-Gn:BSU18590" /db_xref="EnsemblGenomes-Tr:CAB13752" /db_xref="GOA:O31830" /db_xref="InterPro:IPR031374" /db_xref="SubtiList:BG13478" /db_xref="UniProtKB/Swiss-Prot:O31830" /translation="MKKIASYYLMTLGLSSLTFGLLLGFYSFVMYGDMIIALFTAAIA LLYGFVVYGLFAVPLQMKLQKKARTFNVMYLLIYSVVAFIAAFLFFVINEPASIAWTL QSYFYYMLSIAAAVIYWLWDSLILYKRTASGV*" /label="yoaG CDS" gene complement(1855655..1856059) /gene="yoaG" /locus_tag="BSU_18590" /old_locus_tag="BSU18590" /label="yoaG gene" S_feature complement(1856060..1856155) /Source="Nicolas_S_feature" /locus_tag="new_2028580_2028675_c" /HighExp="T0.30H, T1.0H, T0.0H, T-0.40H, S0, T-1.10H, T-1.40H, SMMPr, Salt, Etha" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S691" promotor_-10 complement(1856145..1856160) /Source="Nicolas_upshift_promotors" /id="U1507" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1671 /SigmaFactorBS="ccagcgtattatctaataaaagaacgtcattttTGAAACCTT TtattagcgcattGCGTATAGCACGTTAGggaagacatctcgataaaagaaatacaaa g" /listShort="S691, yoaG, S690" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(1856145..1856264) /locus_tag="BSU_18595" /old_locus_tag="BSU18595" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513962.1" /translation="MHFFHSRFGQSGEAFSASVLSNKRTSFLKPFISALRIAR*" /label="hypothetical protein CDS" gene complement(1856145..1856264) /locus_tag="BSU_18595" /old_locus_tag="BSU18595" /label="gene" upshifts complement(1856155) /Source="Nicolas_upshifts" /id="U1507" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1671 /SigmaFactorBS="ccagcgtattatctaataaaagaacgtcattttTGAAACCTT TtattagcgcattGCGTATAGCACGTTAGggaagacatctcgataaaagaaatacaaa g" /listShort="S691, yoaG, S690" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1856173..1856182) /Source="Nicolas_upshift_promotors" /id="U1507" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1671 /SigmaFactorBS="ccagcgtattatctaataaaagaacgtcattttTGAAACCTT TtattagcgcattGCGTATAGCACGTTAGggaagacatctcgataaaagaaatacaaa g" /listShort="S691, yoaG, S690" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1856260..1856266 /Source="Nicolas_upshift_promotors" /id="U1508" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=915 /SigmaFactorBS="ctgattggccaaagcgcgaatgaaaaaagTGCATGAatacct gcccaacAGACAGAATAAGaagagttgatatttcaacacttttcgtaaaggggtgaaa c" /listShort="S692, yozQ, S693" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1856280..1856291 /Source="Nicolas_upshift_promotors" /id="U1508" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=915 /SigmaFactorBS="ctgattggccaaagcgcgaatgaaaaaagTGCATGAatacct gcccaacAGACAGAATAAGaagagttgatatttcaacacttttcgtaaaggggtgaaa c" /listShort="S692, yozQ, S693" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1856291..1856499 /Source="Nicolas_S_feature" /locus_tag="new_2028811_2029019" /HighExp="S5, S8, S7, S6, S4, ferm, BT, nit, T5.0H, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99998799999999999" /TUshortSig="SigGF, SigWXY" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S692" upshifts 1856291 /Source="Nicolas_upshifts" /id="U1508" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=915 /SigmaFactorBS="ctgattggccaaagcgcgaatgaaaaaagTGCATGAatacct gcccaacAGACAGAATAAGaagagttgatatttcaacacttttcgtaaaggggtgaaa c" /listShort="S692, yozQ, S693" /GFF_Attribute="listLong" /label="upshifts" CDS 1856334..1856456 /locus_tag="BSU_18596" /old_locus_tag="BSU18596" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_009513963.1" /db_xref="EnsemblGenomes-Gn:BSU18596" /db_xref="EnsemblGenomes-Tr:CCQ48597" /db_xref="UniProtKB/TrEMBL:L8E9J0" /translation="MSKKGIQNSSIEQIRNDHETETAFKADDPKKHGSDPKRTK*" /label="conserved hypothetical protein CDS" gene 1856334..1856456 /locus_tag="BSU_18596" /old_locus_tag="BSU18596" /label="gene" CDS 1856500..1856793 /gene="yozQ" /locus_tag="BSU_18600" /old_locus_tag="BSU18600" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22882546" /codon_start=1 /transl_table=11 /product="putative sporulation protein" /protein_id="YP_054581.1" /db_xref="EnsemblGenomes-Gn:BSU18600" /db_xref="EnsemblGenomes-Tr:CAE01456" /db_xref="InterPro:IPR025100" /db_xref="SubtiList:BG14189" /db_xref="UniProtKB/Swiss-Prot:Q7WY68" /translation="MTQKNGADRPDDYKRFSSLDKEYDFQQSIRSNTETESVNTETQT HNKENKNDTTDVAGKYFEPSDYKGSTQLEKGLAETHEQVSDDYFEGTIDQNLD*" /label="yozQ CDS" gene 1856500..1856793 /gene="yozQ" /locus_tag="BSU_18600" /old_locus_tag="BSU18600" /label="yozQ gene" S_feature 1856794..1856887 /Source="Nicolas_S_feature" /locus_tag="new_2029314_2029407" /HighExp="S5, S8, S6, S7, S4, BT, ferm, nit, T5.0H, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigWXY" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S693" downshifts 1856844 /Source="Nicolas_upshifts" /id="D1020" /incds=0 /nref=14 /ntot=74 /MaxReadThrough="3.32407" /MaxDrop="3.87581" /score="-6.27063114" /energy="-3.9" /TU="U1508" /idTUdmin="U1506" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(1856909..1858594) /gene="yoaH" /locus_tag="BSU_18610" /old_locus_tag="BSU18610" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15033535, 27899502; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative methyl-accepting chemotaxis protein" /protein_id="NP_389742.2" /db_xref="EnsemblGenomes-Gn:BSU18610" /db_xref="EnsemblGenomes-Tr:CAB13753" /db_xref="GOA:C0SP89" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR004090" /db_xref="InterPro:IPR007891" /db_xref="SubtiList:BG13479" /db_xref="UniProtKB/Swiss-Prot:C0SP89" /translation="MKVKTKLLGIISILVVSIIGIGGSSVFMISSTVKKNEELKDKME FQKEIKHIQYELTGLSNDERGFLITRDKEYDEGMKGKADDVLKSLDRVNDLIDEEKYQ SNIEDIKTSFTQYRALNQQVVTAYSSNPKKAETIHFGEERTIRKEGVAPAVNKLSDRL DQEVEDLKDEIQGNGKMSQSLIIIVTGISVILGIVLSIMLLKSIMVPLRSINKQLEEI AHGEADLTKKVIVKNKDEFGQLAQSFNSFTHSLTQIVKQISSSSEQVAASSEELSASA EESKSTSEHISRAMQMAADSNVKQSSMTEKSAESITELLDSISSVASNTGNIADLSSS MRDKAEIGSKSVNKMLDQMKFIDKSVDSAGNGLQTLVASTAEISDISSLITTISEQTN LLALNAAIEAARAGEQGKGFAVVAEEVRKLADETNKSANHIQSVVATIQNESIETVNN IKVVQENVSSGIVLSQETTGNFNEILNLVEQVTSQIQEVAAATQQLTSGVEVIQHTVH TLAAGTKETSANTEAVANSSQEQLHSMGEISYAAESLSQLAEELQTVINRFKY*" /label="yoaH CDS" gene complement(1856909..1858594) /gene="yoaH" /locus_tag="BSU_18610" /old_locus_tag="BSU18610" /label="yoaH gene" downshifts complement(1856921) /Source="Nicolas_upshifts" /id="D1021" /incds=0 /nref=68 /ntot=193 /MaxReadThrough="2.22411" /MaxDrop="4.20676" /score="-6.12586993" /energy="-17.4" /TU="NA" /idTUdmin="U1509" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" S_feature complement(1858595..1858682) /Source="Nicolas_S_feature" /locus_tag="new_2031115_2031202_c" /HighExp="Cold, C30, LBGstat, GM 90, GM 15, GM 45, GM 25, GM 60, GM 10, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.115923" /TUshortSig="SigD" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S694" promotor_-10 complement(1858674..1858692) /Source="Nicolas_upshift_promotors" /id="U1509" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=2825 /SigmaFactorBS="agaatttgcttattcatataagaatatcaCTATAAAActtga taacacgtGTCGATATTATGGACATGAgcgtaagcgaattggattcaaacgcgcttga a" /listShort="S694, yoaH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1858682) /Source="Nicolas_upshifts" /id="U1509" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=2825 /SigmaFactorBS="agaatttgcttattcatataagaatatcaCTATAAAActtga taacacgtGTCGATATTATGGACATGAgcgtaagcgaattggattcaaacgcgcttga a" /listShort="S694, yoaH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1858706..1858713) /Source="Nicolas_upshift_promotors" /id="U1509" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=2825 /SigmaFactorBS="agaatttgcttattcatataagaatatcaCTATAAAActtga taacacgtGTCGATATTATGGACATGAgcgtaagcgaattggattcaaacgcgcttga a" /listShort="S694, yoaH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1858851..1858860 /Source="Nicolas_upshift_promotors" /id="U1510" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1325 /SigmaFactorBS="cttattcgtttttctaaaaaaggcttttcccacctcaaattG GCTGAACCGgctgttttctcgAAAATATAATACAATACGCAgcataatatgaaggagc g" /listShort="yoaI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1858870 /Source="Nicolas_upshifts" /id="U1510" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1325 /SigmaFactorBS="cttattcgtttttctaaaaaaggcttttcccacctcaaattG GCTGAACCGgctgttttctcgAAAATATAATACAATACGCAgcataatatgaaggagc g" /listShort="yoaI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1858873..1858892 /Source="Nicolas_upshift_promotors" /id="U1510" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1325 /SigmaFactorBS="cttattcgtttttctaaaaaaggcttttcccacctcaaattG GCTGAACCGgctgttttctcgAAAATATAATACAATACGCAgcataatatgaaggagc g" /listShort="yoaI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1858919..1860370 /gene="yoaI" /locus_tag="BSU_18620" /old_locus_tag="BSU18620" /EC_number="1.14.14.9" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 4-hydroxyphenylacetate-3-hydroxylase" /protein_id="NP_389743.2" /db_xref="EnsemblGenomes-Gn:BSU18620" /db_xref="EnsemblGenomes-Tr:CAB13754" /db_xref="GOA:C0SPC0" /db_xref="InterPro:IPR004925" /db_xref="InterPro:IPR009100" /db_xref="InterPro:IPR012687" /db_xref="InterPro:IPR024674" /db_xref="InterPro:IPR024719" /db_xref="InterPro:IPR036250" /db_xref="SubtiList:BG13480" /db_xref="UniProtKB/Swiss-Prot:C0SPC0" /translation="MGIINGKEFIDRLNKLENEIWYDGEKIKGNISEHPAFKGIIKTK SSLYELQTKDELIHEMTYCLPGDHNRIGLSYLQPKTKNDLKKRRTMIEHWARHTHGMM GRSPDYMNTVMMSFASSAELLKDKENCFPEHILDMYEQAAKHDLSFTHTFITPQVNRS QSYFGLSEKPISAKVIDRTEKGLMIHGARLLATQGGLTDEILVFSAPKFFFETDEAYA FSIPSNTKGVKFITRESFVLSDSSFNHPLSSRYEEMDSIVVFDHVLVPWNRVFFYDNV EAAKDFMTKSSFHAFTFHQVVIRQMIKIEFLLGVAQLLVDTINVSEYQHIQEKLSEII VGLETIKALIDKSENDAQLDEFGYMRPCLIPLQVISTIIPKLYPRFTEIIQLIGASGM VTLPTENAFDSEIREDLDQYLQATNTNAEERVKIFRLAWDLTMSSFGTRQTHYERYFF GDPIRISSRLYTSYPKQEQLNMIKTFLHADTEH*" /label="yoaI CDS" gene 1858919..1860370 /gene="yoaI" /locus_tag="BSU_18620" /old_locus_tag="BSU18620" /label="yoaI gene" downshifts 1860346 /Source="Nicolas_upshifts" /id="D1022" /incds=0 /nref=1 /ntot=19 /MaxReadThrough="2.84304" /MaxDrop="2.93575" /score="2.7297367" /energy="-12" /TU="U1510" /idTUdmin="U1510" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(1860407..1861105) /gene="exlX" /locus_tag="BSU_18630" /old_locus_tag="BSU18630" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12354229, 18971341, 26751268" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 18971341, 26751268; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="extracellular endoglucanase precursor (expansin)" /protein_id="NP_389744.1" /db_xref="EnsemblGenomes-Gn:BSU18630" /db_xref="EnsemblGenomes-Tr:CAB13755" /db_xref="GOA:O34918" /db_xref="InterPro:IPR009009" /db_xref="InterPro:IPR036749" /db_xref="InterPro:IPR036908" /db_xref="PDB:2BH0" /db_xref="PDB:3D30" /db_xref="PDB:4FER" /db_xref="PDB:4FFT" /db_xref="PDB:4FG2" /db_xref="PDB:4FG4" /db_xref="SubtiList:BG13481" /db_xref="UniProtKB/Swiss-Prot:O34918" /translation="MKKIMSAFVGMVLLTIFCFSPQASAAYDDLHEGYATYTGSGYSG GAFLLDPIPSDMEITAINPADLNYGGVKAALAGSYLEVEGPKGKTTVYVTDLYPEGAR GALDLSPNAFRKIGNMKDGKINIKWRVVKAPITGNFTYRIKEGSSRWWAAIQVRNHKY PVMKMEYEKDGKWINMEKMDYNHFVSTNLGTGSLKVRMTDIRGKVVKDTIPKLPESGT SKAYTVPGHVQFPE*" /label="exlX CDS" gene complement(1860407..1861105) /gene="exlX" /locus_tag="BSU_18630" /old_locus_tag="BSU18630" /label="exlX gene" downshifts complement(1860422) /Source="Nicolas_upshifts" /id="D1023" /incds=0 /nref=6 /ntot=95 /MaxReadThrough="0.66874" /MaxDrop="3.60414" /score="1.1918692" /energy="-7.7" /TU="NA" /idTUdmin="U1511" /TUdmin=132 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1861140..1861159) /Source="Nicolas_upshift_promotors" /id="U1511" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.762237762237762" /psig="0.998001998001998" /xcortree=3161 /SigmaFactorBS="tagtgaatttgccttaaaatcaactatgaatctatttccTCT TTCAAaccagatggattgAGTCTTATAATGATAATGATtctcatttgaagtctggttt g" /listShort="exlX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1861159) /Source="Nicolas_upshifts" /id="U1511" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.762237762237762" /psig="0.998001998001998" /xcortree=3161 /SigmaFactorBS="tagtgaatttgccttaaaatcaactatgaatctatttccTCT TTCAAaccagatggattgAGTCTTATAATGATAATGATtctcatttgaagtctggttt g" /listShort="exlX" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1861161..1861374) /Source="Nicolas_S_feature" /locus_tag="new_2033681_2033894_c" /HighExp="G135, H2O2, G150, G180, LBGstat, dia15, LBGtran, Paraq, LBGexp, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S695" promotor_-35 complement(1861173..1861180) /Source="Nicolas_upshift_promotors" /id="U1511" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.762237762237762" /psig="0.998001998001998" /xcortree=3161 /SigmaFactorBS="tagtgaatttgccttaaaatcaactatgaatctatttccTCT TTCAAaccagatggattgAGTCTTATAATGATAATGATtctcatttgaagtctggttt g" /listShort="exlX" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1861375..1862052) /gene="yoaK" /locus_tag="BSU_18640" /old_locus_tag="BSU18640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="NP_389745.1" /db_xref="EnsemblGenomes-Gn:BSU18640" /db_xref="EnsemblGenomes-Tr:CAB13756" /db_xref="GOA:O34343" /db_xref="InterPro:IPR010699" /db_xref="SubtiList:BG13482" /db_xref="UniProtKB/Swiss-Prot:O34343" /translation="MTAAAYRNTLLSLLCLTAGIVDVIGYLSLGHVFTANMTGNIVLL GLAIGKSIQVTVFNSLTALIGFICGVIIATLMVGKAENTLWPSAVTKALALEAFILFV FACLSFYRAFVPVHILIILMSISMGIQTTAAKKLGIAGISSTVLTGTLASLLEDISGR LFFKKQKKTFLRDTVLRALAIILYCVGAIIVALAEPDFYHFIIWVPIVLIFGIMMTAK LKLSGEK*" /label="yoaK CDS" gene complement(1861375..1862052) /gene="yoaK" /locus_tag="BSU_18640" /old_locus_tag="BSU18640" /label="yoaK gene" S_feature complement(1862053..1864542) /Source="Nicolas_S_feature" /locus_tag="new_2034573_2037062_c" /HighExp="LBGstat, G135, H2O2, G180, LBGtran, G150, dia15, Paraq, S0, Diami" /AntisenseName="pelB" /AntisenseCor="0.19898265589133701" /AntisenseRegPval="-3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S696" CDS 1862225..1863262 /gene="pelB" /locus_tag="BSU_18650" /old_locus_tag="BSU18650" /EC_number="4.2.2.10" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1731776, 2018526, 2185758, 7764549, 22695924; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endo-pectin lyase" /protein_id="NP_389746.1" /db_xref="EnsemblGenomes-Gn:BSU18650" /db_xref="EnsemblGenomes-Tr:CAB13757" /db_xref="GOA:O34819" /db_xref="InterPro:IPR002022" /db_xref="InterPro:IPR011050" /db_xref="InterPro:IPR012334" /db_xref="SubtiList:BG12643" /db_xref="UniProtKB/Swiss-Prot:O34819" /translation="MKRLCLWFTVFSLFLVLLPGKALGAVDFPNTSTNGLLGFAGNAK NEKGISKTGTTGGKNGQIVYIQSVNDLKTHLGGSTPKILVLQNDLSASAKTTVTIGSN KTLVGSYAKKTLKNIYLTTSSAFGNVIFQNLTFEHSPQINGNNDIQLYLDSGMNYWID HVTFSGHSYNASGSDLDKLVYIGKSADYITISNSKFANHKYGLILGYPDDSQHQYDGY PHMTIANNYFENLYVRGPGLMRYGYFHVKNNYSNNFNQAITIATKAKIYSEYNYFGKG SEKGGILDDKGTGYFKDIGSYPSLNKQTSPLTSWNPGSNYSYRVQTPEYTKEFVTKYA GSQSTTLVFGY*" /label="pelB CDS" gene 1862225..1863262 /gene="pelB" /locus_tag="BSU_18650" /old_locus_tag="BSU18650" /label="pelB gene" promotor_-35 1863459..1863465 /Source="Nicolas_upshift_promotors" /id="U1512" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=880 /SigmaFactorBS="agtgaaaagaaatcattgttctgaaccTGTATTAaatgaacg atcgtcCCACAAACTACTtaaaaacccctaaaaaggatgatggatatgtgcggcaggt t" /listShort="yoaM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1863480..1863491 /Source="Nicolas_upshift_promotors" /id="U1512" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=880 /SigmaFactorBS="agtgaaaagaaatcattgttctgaaccTGTATTAaatgaacg atcgtcCCACAAACTACTtaaaaacccctaaaaaggatgatggatatgtgcggcaggt t" /listShort="yoaM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1863492 /Source="Nicolas_upshifts" /id="U1512" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=880 /SigmaFactorBS="agtgaaaagaaatcattgttctgaaccTGTATTAaatgaacg atcgtcCCACAAACTACTtaaaaacccctaaaaaggatgatggatatgtgcggcaggt t" /listShort="yoaM" /GFF_Attribute="listLong" /label="upshifts" CDS 1863519..1864202 /gene="yoaM" /locus_tag="BSU_18660" /old_locus_tag="BSU18660" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23945014, 26070154; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative SOS response associated protein; defective prophage 6" /protein_id="NP_389747.1" /db_xref="EnsemblGenomes-Gn:BSU18660" /db_xref="EnsemblGenomes-Tr:CAB13758" /db_xref="GOA:O34906" /db_xref="InterPro:IPR003738" /db_xref="InterPro:IPR036590" /db_xref="SubtiList:BG13483" /db_xref="UniProtKB/Swiss-Prot:O34906" /translation="MCGRFTLYSAFDDIIDQFDIDQFFPKGEYQPSYNVAPSQNILAI INDGSNNRLGKLRWGLIPPWAKDEKIGYKMINARAETITEKPAFRRPLVSKRCIIPAD SFYEWKRLDSKTKIPMRIKLKSSALFAFAGLYEKWSTHQGYPLYTCTIITTEPNEFMK DIHDRMPVILAHDHEKEWLNPKNTSPDYLQSLLLPYDADDMEAYQVSSLVNSPKNNSA ELLDAENHM*" /label="yoaM CDS" gene 1863519..1864202 /gene="yoaM" /locus_tag="BSU_18660" /old_locus_tag="BSU18660" /label="yoaM gene" CDS complement(1864543..1864848) /gene="yozS" /locus_tag="BSU_18669" /old_locus_tag="BSU18669" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative permease, phage-related; defective prophage 6" /protein_id="YP_003097734.1" /db_xref="EnsemblGenomes-Gn:BSU18669" /db_xref="EnsemblGenomes-Tr:CAX52628" /db_xref="GOA:C0H420" /db_xref="UniProtKB/Swiss-Prot:C0H420" /translation="MKALIFLSSLTAIGSSILGRWLGMLDDSYAVGDAWFIGVLAGLI SLLILIDSQTMTKNYIVSLSTILGILGVGFIYFPAAFINILLSITLDKQKKEDLHVR* " /label="yozS CDS" gene complement(1864543..1864848) /gene="yozS" /locus_tag="BSU_18669" /old_locus_tag="BSU18669" /label="yozS gene" S_feature complement(1864849..1864950) /Source="Nicolas_S_feature" /locus_tag="new_2037369_2037470_c" /HighExp="HiTm, LBGstat, LBGtran, T1.30H, T1.0H, T0.30H, M9-stat, Lbstat, M0t90, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S697" promotor_-10 complement(1864929..1864948) /Source="Nicolas_upshift_promotors" /id="U1513" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=3228 /SigmaFactorBS="tttattaaatccctatatatacgttatgtagggtttttctGC TTGAATcgtattgtaatgagCTTTAAAATGTTAATGTGGAaatgaaatggtaaccatt c" /listShort="S697, yozS, S696" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1864950) /Source="Nicolas_upshifts" /id="U1513" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=3228 /SigmaFactorBS="tttattaaatccctatatatacgttatgtagggtttttctGC TTGAATcgtattgtaatgagCTTTAAAATGTTAATGTGGAaatgaaatggtaaccatt c" /listShort="S697, yozS, S696" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1864963..1864970) /Source="Nicolas_upshift_promotors" /id="U1513" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=3228 /SigmaFactorBS="tttattaaatccctatatatacgttatgtagggtttttctGC TTGAATcgtattgtaatgagCTTTAAAATGTTAATGTGGAaatgaaatggtaaccatt c" /listShort="S697, yozS, S696" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1864978..1865080) /Source="Nicolas_S_feature" /locus_tag="new_2037498_2037600_c" /HighExp="S8, S6, S7, S5, BT, G/S, Pyr, B36, nit, SMMPr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S698" downshifts complement(1865020) /Source="Nicolas_upshifts" /id="D1024" /incds=0 /nref=9 /ntot=21 /MaxReadThrough="1.67639" /MaxDrop="3.95763" /score="-5.39979801" /energy="-8.3" /TU="NA" /idTUdmin="U1514" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1865081..1866259) /gene="oxdD" /locus_tag="BSU_18670" /old_locus_tag="BSU18670" /EC_number="4.1.1.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11546787, 14697267, 14973022, 15628860, 25526893" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11546787, 14697267, 14973022, 15628860, 25526893; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oxalate decarboxylase (Mn2+-dependent); spore constituent" /protein_id="NP_389748.1" /db_xref="EnsemblGenomes-Gn:BSU18670" /db_xref="EnsemblGenomes-Tr:CAB13759" /db_xref="GOA:O34767" /db_xref="InterPro:IPR006045" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR017774" /db_xref="SubtiList:BG13484" /db_xref="UniProtKB/Swiss-Prot:O34767" /translation="MLLEQQPINHEDRNVPQPIRSDGAGAIDTGPRNIIRDIQNPNIF VPPVTDEGMIPNLRFSFSDAPMKLDHGGWSREITVRQLPISTAIAGVNMSLTAGGVRE LHWHKQAEWAYMLLGRARITAVDQDGRNFIADVGPGDLWYFPAGIPHSIQGLEHCEFL LVFDDGNFSEFSTLTISDWLAHTPKDVLSANFGVPENAFNSLPSEQVYIYQGNVPGSV ASEDIQSPYGKVPMTFKHELLNQPPIQMPGGSVRIVDSSNFPISKTIAAALVQIEPGA MRELHWHPNSDEWQYYLTGQGRMTVFIGNGTARTFDYRAGDVGYVPSNAGHYIQNTGT ETLWFLEMFKSNRYADVSLNQWMALTPKELVQSNLNAGSVMLDSLRKKKVPVVKYPGT *" /label="oxdD CDS" gene complement(1865081..1866259) /gene="oxdD" /locus_tag="BSU_18670" /old_locus_tag="BSU18670" /label="oxdD gene" promotor_-10 complement(1866285..1866304) /Source="Nicolas_upshift_promotors" /id="U1514" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1289 /SigmaFactorBS="tgatcacattggtggtcacttttttatttgcggattcCTAGG CACAGcaatctaagattcTGCATAGGCTGAAATAAAATcttgttcatttctaaaacga g" /listShort="yoaN, S698" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1866304) /Source="Nicolas_upshifts" /id="U1514" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1289 /SigmaFactorBS="tgatcacattggtggtcacttttttatttgcggattcCTAGG CACAGcaatctaagattcTGCATAGGCTGAAATAAAATcttgttcatttctaaaacga g" /listShort="yoaN, S698" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1866318..1866327) /Source="Nicolas_upshift_promotors" /id="U1514" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1289 /SigmaFactorBS="tgatcacattggtggtcacttttttatttgcggattcCTAGG CACAGcaatctaagattcTGCATAGGCTGAAATAAAATcttgttcatttctaaaacga g" /listShort="yoaN, S698" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1866382..1866870) /gene="yoaO" /locus_tag="BSU_18680" /old_locus_tag="BSU18680" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389749.1" /db_xref="EnsemblGenomes-Gn:BSU18680" /db_xref="EnsemblGenomes-Tr:CAB13760" /db_xref="InterPro:IPR032545" /db_xref="SubtiList:BG13485" /db_xref="UniProtKB/Swiss-Prot:O34985" /translation="MRKKNNIKKWLLIIAGFLIICIITLFVMVSGNKVKYEGSGKSGL WMSNLEKSDKTSIGPNYFLNLYWQGSKKEEKWTVVERITLYVDGEKYQDDNVDEYDLS EYTGDEMPGGGRMEDHISTFDYMPEDEVIGHDVLVKVEWRTGQKKQTEAIKLHKKPWY KK*" /label="yoaO CDS" gene complement(1866382..1866870) /gene="yoaO" /locus_tag="BSU_18680" /old_locus_tag="BSU18680" /label="yoaO gene" downshifts complement(1866407) /Source="Nicolas_upshifts" /id="D1025" /incds=0 /nref=32 /ntot=201 /MaxReadThrough="0.50319" /MaxDrop="3.84714" /score="18.561323" /energy="-9.2" /TU="NA" /idTUdmin="U1514" /TUdmin="-1387" /isTUend="FALSE" /label="downshifts" CDS complement(1866895..1867050) /locus_tag="BSU_18689" /old_locus_tag="BSU18689" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513964.1" /translation="MKQKMHLRAVIRFNLVFRKHFNLSQKFRQSSVRSLALSYFLFGN ILIVFSY*" /label="hypothetical protein CDS" gene complement(1866895..1867050) /locus_tag="BSU_18689" /old_locus_tag="BSU18689" /label="gene" CDS complement(1867090..1867845) /gene="yoaP" /locus_tag="BSU_18690" /old_locus_tag="BSU18690" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389750.1" /db_xref="EnsemblGenomes-Gn:BSU18690" /db_xref="EnsemblGenomes-Tr:CAB13761" /db_xref="GOA:O34983" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR025685" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG13486" /db_xref="UniProtKB/Swiss-Prot:O34983" /translation="MCYIEITKDNIEDNHICCALSTKQYEHAVNEKKRWLKARMDEGL VFYRLHERAKVFIEYLPANEAWVPINAPNFMYINCLWVSGRYKNNGHAKRLLDKCIAD AKACGMDGIIHIAGKKKLPYLSDKHFFEHMGFTLQDEAAPYFQLMALTWNGLADSPAF KSQVKSDSINEKGITIYYTAQCPFAVGMINDLRELTEKKGVQFQSIQLSSKEEAQKSP AIWTTFSVFFDGRFVTHEIMSINKFEKLLNTLA*" /label="yoaP CDS" gene complement(1867090..1867845) /gene="yoaP" /locus_tag="BSU_18690" /old_locus_tag="BSU18690" /label="yoaP gene" promotor_-35 1868098..1868103 /Source="Nicolas_upshift_promotors" /id="U1515" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1037 /SigmaFactorBS="agtacacgaagttttttatttgaaGTAATAtttgttacggga cagCAATAGTAAATAAGTGATAaaaggggaattaaacttggtggaaaaatgttattct t" /listShort="yoaQ, S699" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1868119..1868137 /Source="Nicolas_upshift_promotors" /id="U1515" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1037 /SigmaFactorBS="agtacacgaagttttttatttgaaGTAATAtttgttacggga cagCAATAGTAAATAAGTGATAaaaggggaattaaacttggtggaaaaatgttattct t" /listShort="yoaQ, S699" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1868134 /Source="Nicolas_upshifts" /id="U1515" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1037 /SigmaFactorBS="agtacacgaagttttttatttgaaGTAATAtttgttacggga cagCAATAGTAAATAAGTGATAaaaggggaattaaacttggtggaaaaatgttattct t" /listShort="yoaQ, S699" /GFF_Attribute="listLong" /label="upshifts" CDS 1868153..1868509 /gene="yoaQ" /locus_tag="BSU_18700" /old_locus_tag="BSU18700" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389751.1" /db_xref="EnsemblGenomes-Gn:BSU18700" /db_xref="EnsemblGenomes-Tr:CAB13762" /db_xref="SubtiList:BG13487" /db_xref="UniProtKB/Swiss-Prot:O31831" /translation="MVEKCYSCLICGYKGLIQNPLYKGEYQKTFDICPCCGFEFGYSE DHDVRLGFIVTPDHLIEAAFQLYRKQWLESGMVIAHPEDIPEELKNGNCLKFEVLLKQ LKKLNLDIENFEISGF*" /label="yoaQ CDS" gene 1868153..1868509 /gene="yoaQ" /locus_tag="BSU_18700" /old_locus_tag="BSU18700" /label="yoaQ gene" CDS complement(1868468..1868707) /gene="yozT" /locus_tag="BSU_18709" /old_locus_tag="BSU18709" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein (putative phage origin); putative defective prophage 6" /protein_id="YP_003097735.1" /db_xref="EnsemblGenomes-Gn:BSU18709" /db_xref="EnsemblGenomes-Tr:CAX52629" /db_xref="UniProtKB/Swiss-Prot:C0H421" /translation="MTVINDYREEPEEAFWILYPMGVKCLSMITKSLLNTNRDFVTDC AFQLNILLIMTVKPKQVQPVSSLKTANFKIFYVKI*" /label="yozT CDS" gene complement(1868468..1868707) /gene="yozT" /locus_tag="BSU_18709" /old_locus_tag="BSU18709" /label="yozT gene" S_feature 1868510..1868946 /Source="Nicolas_S_feature" /locus_tag="new_2041030_2041466" /HighExp="S8, S7, S4, S5, S6, S3, T5.0H, LoTm, BT, T4.0H" /AntisenseName="yozT" /AntisenseCor="0.93420248567111996" /AntisenseRegPval="-120.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S699" S_feature complement(1868708..1868809) /Source="Nicolas_S_feature" /locus_tag="new_2041228_2041329_c" /HighExp="S8, S7, S6, S5, S4, BT, ferm, nit, S3, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S700" CDS complement(1868810..1869307) /gene="yozF" /locus_tag="BSU_18710" /old_locus_tag="BSU18710" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_389752.2" /db_xref="EnsemblGenomes-Gn:BSU18710" /db_xref="EnsemblGenomes-Tr:CAB13763" /db_xref="SubtiList:BG13753" /db_xref="UniProtKB/Swiss-Prot:O31832" /translation="MKRVLFSVIVFTAVGFTFCQSKAHALTFTVLPITQKTDQWSVKV SEAKNVKEFTRPHKGEYQVYSLEVKNIGEKAATVDVQLYRNDPNSITRFSLFGCPDEN CVKPKEDSKMLAESLNDGSPLKFNHFMLADKASELEVVIIWTQKGQEGRNLKQTFKFT EDGVN*" /label="yozF CDS" gene complement(1868810..1869307) /gene="yozF" /locus_tag="BSU_18710" /old_locus_tag="BSU18710" /label="yozF gene" S_feature complement(1869308..1869407) /Source="Nicolas_S_feature" /locus_tag="new_2041828_2041927_c" /HighExp="S8, S7, S5, S6, S4, BT, ferm, nit, S3, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S701" CDS complement(1869408..1870319) /gene="yoaR" /locus_tag="BSU_18720" /old_locus_tag="BSU18720" /function="16.8: Protect" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8631706; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative factor for cell wall maintenance or synthesis" /protein_id="NP_389753.1" /db_xref="EnsemblGenomes-Gn:BSU18720" /db_xref="EnsemblGenomes-Tr:CAB13764" /db_xref="InterPro:IPR007391" /db_xref="SubtiList:BG13488" /db_xref="UniProtKB/Swiss-Prot:O34611" /translation="MIQILITGLFLLAQPSEPQDSLTVTQQGRTIATVNREDFTMPLP GTPMVDYEKYSKFIKQLDQKVYREPINAVLNDHGSIVPGRVGYKLYQQAFMEKFYAYF YGQGPSKIEVPEMNIYPKVDSELLAHISTQQLGQYVTYFNSSNKSRSHNISLSAKAID NHVVFPNETFSFNQVVGMRTRNKGYKSAPIIVKGELSEGVGGGICQVSSTLFNAVDRA GLQIVQRYSHTRSVPYVPPGRDATVSWGGPDFRFQNQYNQPILIRAKRYGGSMIITLY SSDVINSRLRKIPKAPSRIPKEINAEQ*" /label="yoaR CDS" gene complement(1869408..1870319) /gene="yoaR" /locus_tag="BSU_18720" /old_locus_tag="BSU18720" /label="yoaR gene" promotor_-10 complement(1870341..1870352) /Source="Nicolas_upshift_promotors" /id="U1516" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=941 /SigmaFactorBS="ctaaagattcaaacaaacgatgggaagaaaTACATCAaagga taagcggctGTTCATACTAATgattgggaggtaaaccgacttatgatacaaattttga t" /listShort="yoaR, S701, yozF, S700, yozT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1870343) /Source="Nicolas_upshifts" /id="U1516" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=941 /SigmaFactorBS="ctaaagattcaaacaaacgatgggaagaaaTACATCAaagga taagcggctGTTCATACTAATgattgggaggtaaaccgacttatgatacaaattttga t" /listShort="yoaR, S701, yozF, S700, yozT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1870367..1870373) /Source="Nicolas_upshift_promotors" /id="U1516" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=941 /SigmaFactorBS="ctaaagattcaaacaaacgatgggaagaaaTACATCAaagga taagcggctGTTCATACTAATgattgggaggtaaaccgacttatgatacaaattttga t" /listShort="yoaR, S701, yozF, S700, yozT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1870603..1870610 /Source="Nicolas_upshift_promotors" /id="U1517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.906093906093906" /psig="0.999000999001" /xcortree=2172 /SigmaFactorBS="ggtctcctataacaacaaaaaatcaatccatttcaatatttt ttTATTGAGAaacgataaatttttTGTTACATTCAATTAGACAAcaaataaatgaggt g" /listShort="yoaS, yozG, S702, yoaT, S703" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1870619 /Source="Nicolas_upshifts" /id="U1517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.906093906093906" /psig="0.999000999001" /xcortree=2172 /SigmaFactorBS="ggtctcctataacaacaaaaaatcaatccatttcaatatttt ttTATTGAGAaacgataaatttttTGTTACATTCAATTAGACAAcaaataaatgaggt g" /listShort="yoaS, yozG, S702, yoaT, S703" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1870625..1870644 /Source="Nicolas_upshift_promotors" /id="U1517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.906093906093906" /psig="0.999000999001" /xcortree=2172 /SigmaFactorBS="ggtctcctataacaacaaaaaatcaatccatttcaatatttt ttTATTGAGAaacgataaatttttTGTTACATTCAATTAGACAAcaaataaatgaggt g" /listShort="yoaS, yozG, S702, yoaT, S703" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1870666..1871148 /gene="yoaS" /locus_tag="BSU_18730" /old_locus_tag="BSU18730" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 19493340; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative toxin of a toxin / antitoxin system" /protein_id="NP_389754.1" /db_xref="EnsemblGenomes-Gn:BSU18730" /db_xref="EnsemblGenomes-Tr:CAB13765" /db_xref="GOA:O31833" /db_xref="InterPro:IPR021354" /db_xref="SubtiList:BG13489" /db_xref="UniProtKB/Swiss-Prot:O31833" /translation="MNRMSTIFLKIALVLIGIPILALCIFLVPKVANYSAELFPNIAY IKYLVFIYLYVTAIPFYFALYQAFKLLSYIDKNKAFSGLSVRALKNIKYCAVTISIFY AAGMPVFYLMAEIDDAPGIIVIGLVIIFASMVIAVFAAVLQKLLKEAIDIKSENDLTV *" /label="yoaS CDS" gene 1870666..1871148 /gene="yoaS" /locus_tag="BSU_18730" /old_locus_tag="BSU18730" /label="yoaS gene" CDS 1871158..1871412 /gene="yozG" /locus_tag="BSU_18740" /old_locus_tag="BSU18740" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19493340; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative antitoxin of a toxin / antitoxin system; putative transcriptional regulator" /protein_id="NP_389755.1" /db_xref="EnsemblGenomes-Gn:BSU18740" /db_xref="EnsemblGenomes-Tr:CAB13766" /db_xref="GOA:O31834" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="SubtiList:BG13754" /db_xref="UniProtKB/Swiss-Prot:O31834" /translation="MAIIINIDVMLAKRKMSVTELSERVGITMANLSILKNGKAKAIR LSTLEAICKALECQPGDILEYRSDEDTGFVKKKYEGSTEK*" /label="yozG CDS" gene 1871158..1871412 /gene="yozG" /locus_tag="BSU_18740" /old_locus_tag="BSU18740" /label="yozG gene" S_feature 1871413..1871517 /Source="Nicolas_S_feature" /locus_tag="new_2043933_2044037" /HighExp="LoTm, B60, Sw, G135, G180, B36, LBGstat, Cold, LBGtran, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S702" CDS 1871518..1872312 /gene="yoaT" /locus_tag="BSU_18750" /old_locus_tag="BSU18750" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_389756.1" /db_xref="EnsemblGenomes-Gn:BSU18750" /db_xref="EnsemblGenomes-Tr:CAB13767" /db_xref="GOA:O34535" /db_xref="InterPro:IPR008535" /db_xref="SubtiList:BG13490" /db_xref="UniProtKB/Swiss-Prot:O34535" /translation="MRAIKQIVHFGWEQALSCLFPAVIFASLAITQIIPLPFLPRYDW LLIICVLMQLWMVRSGLETRDELKVITLFHLIGLALELFKVHMGSWSYPEEGYSKIFG VPLYSGFMYASVASYLCQAWRRLKVELVKWPSFFAVVPLAAAIYLNFFTHHFSIDIRW WLSGLVIIVFWQTWVTYEVNGARYRMPLALSFILIGFFIWIAENIATFFGAWKYPNQI DTWSLVHLGKVSSWLLLVIVSFLIVASLKQVKEQSPTKAEMDESFS*" /label="yoaT CDS" gene 1871518..1872312 /gene="yoaT" /locus_tag="BSU_18750" /old_locus_tag="BSU18750" /label="yoaT gene" S_feature 1872313..1873323 /Source="Nicolas_S_feature" /locus_tag="new_2044833_2045843" /HighExp="LoTm, Cold, Sw, H2O2, B60, GM 10, S8, dia15, T2.30H, MG 60" /AntisenseName="yoaU" /AntisenseCor="-2.6976304882719598E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S703" CDS complement(1872436..1873308) /gene="yoaU" /locus_tag="BSU_18760" /old_locus_tag="BSU18760" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17526699; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (LysR family)" /protein_id="NP_389757.1" /db_xref="EnsemblGenomes-Gn:BSU18760" /db_xref="EnsemblGenomes-Tr:CAB13768" /db_xref="GOA:O34701" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13491" /db_xref="UniProtKB/Swiss-Prot:O34701" /translation="MVMNMNHLHIFVKVGEKLNITEAAKELFISQPAVSKAIKNLESS LQLKLLIRDKHHGLMLTDIGKEILLLARQMKGIESKIYQVANRENKLLNGKVKIGSFP AVSTNIMPQAIAAFRSNYPLIRIELIEGTSDQIKGWVEDRTVDIGIAASPFEPFENQL LCNDYMVAVIPPQRDELKLEKHVDLETYQDDLIFCKGGHEIAMSNAFSQYNIELKENL TVQNAETLINMVKNNLGIGIISNFTLSSVPHQLIKKDIFPRVTRDIGVIAHSFEEITP AAHEFVKVLKAVVI*" /label="yoaU CDS" gene complement(1872436..1873308) /gene="yoaU" /locus_tag="BSU_18760" /old_locus_tag="BSU18760" /label="yoaU gene" CDS 1873409..1874287 /gene="yoaV" /locus_tag="BSU_18770" /old_locus_tag="BSU18770" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10844694, 11717295, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative modified amino acid or TCA compound efflux permease" /protein_id="NP_389758.1" /db_xref="EnsemblGenomes-Gn:BSU18770" /db_xref="EnsemblGenomes-Tr:CAB13769" /db_xref="GOA:O34416" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG13492" /db_xref="UniProtKB/Swiss-Prot:O34416" /translation="MVKVMLGIISVTLIWGYTWVAMKVGIHDIPPLLFSGLRLFIGAV PLFLILFIQRKKLSIQKEHLKSYIIMSLLMGLGYMGILTYGMQFVDSGKTSVLVYTMP IFVTVISHFSLNEKMNVYKTMGLVCGLFGLLFIFGKEMLNIDQSALFGELCVLVAALS WGIANVFSKLQFKHIDIIHMNAWHLMMGAVMLLVFSFIFEAVPSAEWTYQAVWSLLFN GLLSTGFTFVVWFWVLNQIQASKASMALMFVPVLALFFGWLQLHEQITINIILGALLI CCGIFMNTFTFSRRKV*" /label="yoaV CDS" gene 1873409..1874287 /gene="yoaV" /locus_tag="BSU_18770" /old_locus_tag="BSU18770" /label="yoaV gene" S_feature complement(1874400..1874459) /Source="Nicolas_S_feature" /locus_tag="new_2046920_2046979_c" /HighExp="BC, T4.0H, M9-stat, S5, T5.0H, S4, S3, T3.0H, T3.30H, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.167154" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S704" downshifts complement(1874435) /Source="Nicolas_upshifts" /id="D1026" /incds=0 /nref=55 /ntot=175 /MaxReadThrough="1.78313" /MaxDrop="5.17096" /score="15.465237" /energy="-12.3" /TU="NA" /idTUdmin="U1518" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1874460..1874891) /gene="yoaW" /locus_tag="BSU_18780" /old_locus_tag="BSU18780" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15101989" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15101989; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="biofilm forming exported protein" /protein_id="NP_389759.1" /db_xref="EnsemblGenomes-Gn:BSU18780" /db_xref="EnsemblGenomes-Tr:CAB13770" /db_xref="SubtiList:BG13493" /db_xref="UniProtKB/Swiss-Prot:O34541" /translation="MKKMLMLAFTFLLALTIHVGEASAVIVKDEEKVSFTMTENEKWF MKSDDLNSNHWTSHFGYRFTIFDTEGCTINARIMRMTLSGYEITVSEKNFSGDHFDFS ATDRVETMPYKTHYLILTKDPDCGDVKVKGLYGFQFDQPEW*" /label="yoaW CDS" gene complement(1874460..1874891) /gene="yoaW" /locus_tag="BSU_18780" /old_locus_tag="BSU18780" /label="yoaW gene" promotor_-10 complement(1874911..1874930) /Source="Nicolas_upshift_promotors" /id="U1518" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.432567432567433" /psig=1 /xcortree=485 /SigmaFactorBS="ggtgctaaagattcatttggagaagactgTCTTGATcagaaa agaccctTCCAATATATTGAAGTAAAAgatatcgggaggaactcttttgaaaaagatg t" /listShort="yoaW" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1874919) /Source="Nicolas_upshifts" /id="U1518" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.432567432567433" /psig=1 /xcortree=485 /SigmaFactorBS="ggtgctaaagattcatttggagaagactgTCTTGATcagaaa agaccctTCCAATATATTGAAGTAAAAgatatcgggaggaactcttttgaaaaagatg t" /listShort="yoaW" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1874921..1875154) /Source="Nicolas_S_feature" /locus_tag="new_2047441_2047674_c" /HighExp="S4, S3, S5, S7, S8, S6, LoTm, T5.0H, T4.0H, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S705" promotor_-35 complement(1874944..1874950) /Source="Nicolas_upshift_promotors" /id="U1518" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.432567432567433" /psig=1 /xcortree=485 /SigmaFactorBS="ggtgctaaagattcatttggagaagactgTCTTGATcagaaa agaccctTCCAATATATTGAAGTAAAAgatatcgggaggaactcttttgaaaaagatg t" /listShort="yoaW" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1875155..1875173) /Source="Nicolas_upshift_promotors" /id="U1519" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1172 /SigmaFactorBS="gtataagctaaataagactcaaaagccTGAATAtttctttga gctaatGAATACAATAAATCGATAGaaaacactttagcagttttttgtagtgctcctg a" /listShort="S705, yoaW" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(1875155..1875787) /gene="yoaZ" /locus_tag="BSU_18790" /old_locus_tag="BSU18790" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16181642; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative factor of the oxidative stress response" /protein_id="NP_389760.1" /db_xref="EnsemblGenomes-Gn:BSU18790" /db_xref="EnsemblGenomes-Tr:CAB13771" /db_xref="GOA:O34947" /db_xref="InterPro:IPR002818" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG13494" /db_xref="UniProtKB/Swiss-Prot:O34947" /translation="MQTRKVYLYVFHTMSDWEYGYLIAELNSGRYFKQDAASLKVVTV GVNKEMITTLGGLSIKPDISLDECTLGSQDLIILPGGNTWGEDIHQPILKKVGDALKL GTTIAAICGATLGLANEGYLNSRKHTSNDLDYMNMVCPNYKGETFYEKGPAVSDENLV TASGIAPLEFAVEVLKKLDVFAPDTLRSWYKLNKTQKPEYFFELMNTINR*" /label="yoaZ CDS" gene complement(1875155..1875787) /gene="yoaZ" /locus_tag="BSU_18790" /old_locus_tag="BSU18790" /label="yoaZ gene" upshifts complement(1875161) /Source="Nicolas_upshifts" /id="U1519" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1172 /SigmaFactorBS="gtataagctaaataagactcaaaagccTGAATAtttctttga gctaatGAATACAATAAATCGATAGaaaacactttagcagttttttgtagtgctcctg a" /listShort="S705, yoaW" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1875189..1875194) /Source="Nicolas_upshift_promotors" /id="U1519" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1172 /SigmaFactorBS="gtataagctaaataagactcaaaagccTGAATAtttctttga gctaatGAATACAATAAATCGATAGaaaacactttagcagttttttgtagtgctcctg a" /listShort="S705, yoaW" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1875925..1875932 /Source="Nicolas_upshift_promotors" /id="U1520" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.84015984015984" /psig="0.999000999001" /xcortree=3062 /SigmaFactorBS="ccaacttataaaaatataagatcaattgattctaTGTTTACT agcgcaaaggggttTGTTACACTAACTGTCATGGgaaacatttcaaaggtaatacaaa a" /listShort="penP, S706" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1875947..1875966 /Source="Nicolas_upshift_promotors" /id="U1520" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.84015984015984" /psig="0.999000999001" /xcortree=3062 /SigmaFactorBS="ccaacttataaaaatataagatcaattgattctaTGTTTACT agcgcaaaggggttTGTTACACTAACTGTCATGGgaaacatttcaaaggtaatacaaa a" /listShort="penP, S706" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1875951 /Source="Nicolas_upshifts" /id="U1520" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.84015984015984" /psig="0.999000999001" /xcortree=3062 /SigmaFactorBS="ccaacttataaaaatataagatcaattgattctaTGTTTACT agcgcaaaggggttTGTTACACTAACTGTCATGGgaaacatttcaaaggtaatacaaa a" /listShort="penP, S706" /GFF_Attribute="listLong" /label="upshifts" CDS 1876013..1876933 /gene="penP" /locus_tag="BSU_18800" /old_locus_tag="BSU18800" /EC_number="3.5.2.6" /function="16.5: Explore" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7789815, 15187182, 16944130, 22211522, 25112476, 25355936; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="beta-lactamase precursor (putative hydrolase)" /protein_id="NP_389761.1" /db_xref="EnsemblGenomes-Gn:BSU18800" /db_xref="EnsemblGenomes-Tr:CAB13772" /db_xref="GOA:P39824" /db_xref="InterPro:IPR000871" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR023650" /db_xref="SubtiList:BG11016" /db_xref="UniProtKB/Swiss-Prot:P39824" /translation="MKLKTKASIKFGICVGLLCLSITGFTPFFNSTHAEAKSIEDTNM ASCITNKKFVQLEKKFDARLGVYAIDIGSNKTIAYRPNERFAYASTYKVLAAAAVLKK NSIEKLNEVIHYSKDDLVTYSPITEKHLDTGMSLKEISEAAIRYSDNTAGNILLQQLG GPKGFEKSLKQIGDHVTKAKRFETDLNSAIPGDIRDTSTAKALATDLKAFTLDNTLTT DKRMILTDWMRGNATGDELIRAGAPIGWEVGDKSGAGSYGTRNDIAIVWPPNRAPIVV AILSNRFTKDANYDNALIAEAAKVVLNDLK*" /label="penP CDS" gene 1876013..1876933 /gene="penP" /locus_tag="BSU_18800" /old_locus_tag="BSU18800" /label="penP gene" promotor_-10 complement(1876444..1876463) /Source="Nicolas_upshift_promotors" /id="U1521" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.744255744255744" /psig="0.995004995004995" /xcortree=426 /SigmaFactorBS="cagtgacttttcaaaacctttagggccgccaagcTGTTGCAA caagatgttcccagCGGTATTATCGCTGTAACGGatagccgcttccgagatttctttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1876459) /Source="Nicolas_upshifts" /id="U1521" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.744255744255744" /psig="0.995004995004995" /xcortree=426 /SigmaFactorBS="cagtgacttttcaaaacctttagggccgccaagcTGTTGCAA caagatgttcccagCGGTATTATCGCTGTAACGGatagccgcttccgagatttctttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1876478..1876485) /Source="Nicolas_upshift_promotors" /id="U1521" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.744255744255744" /psig="0.995004995004995" /xcortree=426 /SigmaFactorBS="cagtgacttttcaaaacctttagggccgccaagcTGTTGCAA caagatgttcccagCGGTATTATCGCTGTAACGGatagccgcttccgagatttctttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1876934..1877591 /Source="Nicolas_S_feature" /locus_tag="new_2049454_2050111" /HighExp="HiOs, S8, GM 25, GM 15, GM-0.1, C30, S2, S1, BC, GM 45" /AntisenseName="yobA" /AntisenseCor="8.9918765131424994E-2" /AntisenseRegPval="-0.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S706" CDS complement(1877430..1877792) /gene="yobA" /locus_tag="BSU_18810" /old_locus_tag="BSU18810" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_389762.1" /db_xref="EnsemblGenomes-Gn:BSU18810" /db_xref="EnsemblGenomes-Tr:CAB13773" /db_xref="InterPro:IPR021598" /db_xref="PDB:2JQO" /db_xref="PDB:4QY7" /db_xref="SubtiList:BG13495" /db_xref="UniProtKB/Swiss-Prot:O31835" /translation="MPKIGVSLIVLIMLIIFLAGCNKNEQNGDETKMQSLVGYVVLKD NERAILITDTKAPGKEDYNLSEGQLMNKFKNNIVIVGLSEIDNTDDLKRGEKIKVWFH TRKESNPPSATIQKYELL*" /label="yobA CDS" gene complement(1877430..1877792) /gene="yobA" /locus_tag="BSU_18810" /old_locus_tag="BSU18810" /label="yobA gene" CDS complement(1877853..1878065) /gene="yozU" /locus_tag="BSU_18819" /old_locus_tag="BSU18819" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; Product type h : extrachromosomal origin" /pseudo /codon_start=1 /transl_table=11 /product="putative phage protein" /db_xref="PSEUDO:CAX52630.1" /translation="MEVAIVNDSKDKYIYAGIQKEAAFNNIFESAKMSKRIISRATTC KYLRKNKKKVEELENEYAAVMNCKKK*" /label="yozU CDS" gene complement(1877853..1878065) /gene="yozU" /locus_tag="BSU_18819" /old_locus_tag="BSU18819" /pseudo /label="yozU gene" promotor_-35 1878104..1878111 /Source="Nicolas_upshift_promotors" /id="U1522" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig="0.967032967032967" /xcortree=487 /SigmaFactorBS="aatcgagatttttactttttttatgatccattattCACTTCC AaaataacttccaatTACAACATAATATATGTATAaattgtaaatggagttgatgtaa t" /listShort="yobB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1878126..1878145 /Source="Nicolas_upshift_promotors" /id="U1522" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig="0.967032967032967" /xcortree=487 /SigmaFactorBS="aatcgagatttttactttttttatgatccattattCACTTCC AaaataacttccaatTACAACATAATATATGTATAaattgtaaatggagttgatgtaa t" /listShort="yobB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1878129 /Source="Nicolas_upshifts" /id="U1522" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig="0.967032967032967" /xcortree=487 /SigmaFactorBS="aatcgagatttttactttttttatgatccattattCACTTCC AaaataacttccaatTACAACATAATATATGTATAaattgtaaatggagttgatgtaa t" /listShort="yobB" /GFF_Attribute="listLong" /label="upshifts" CDS 1878169..1878432 /gene="yobB" /locus_tag="BSU_18820" /old_locus_tag="BSU18820" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10376821; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator from bacteriophage; putative defective prophage 6" /protein_id="NP_389763.1" /db_xref="EnsemblGenomes-Gn:BSU18820" /db_xref="EnsemblGenomes-Tr:CAB13774" /db_xref="SubtiList:BG13496" /db_xref="UniProtKB/Swiss-Prot:O31836" /translation="MKIRKILLSSALSFGMLISAVPALAAGTSSEVAVKNEEYDYDTI YRISPLPMDFQPTIEYNGYTYTLTRHYFDYSIGFYTAIYTKVV*" /label="yobB CDS" gene 1878169..1878432 /gene="yobB" /locus_tag="BSU_18820" /old_locus_tag="BSU18820" /label="yobB gene" downshifts 1878410 /Source="Nicolas_upshifts" /id="D1027" /incds=0 /nref=23 /ntot=100 /MaxReadThrough="0.60454" /MaxDrop="4.81085" /score="19.5390064" /energy="-8.7" /TU="NA" /idTUdmin="U1522" /TUdmin=3 /isTUend="TRUE" /label="downshifts" CDS complement(1878809..1881409) /gene="yppS" /locus_tag="BSU_18830" /old_locus_tag="BSU18830" /EC_number="2.7.9.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative PEP-dependent enzyme" /protein_id="NP_389764.1" /db_xref="EnsemblGenomes-Gn:BSU18830" /db_xref="EnsemblGenomes-Tr:CAB13775" /db_xref="GOA:O34309" /db_xref="InterPro:IPR002192" /db_xref="InterPro:IPR008279" /db_xref="InterPro:IPR013815" /db_xref="SubtiList:BG12657" /db_xref="UniProtKB/Swiss-Prot:O34309" /translation="MSSLVLGLHEIEKTQLSLVGGKGLHLGELSKIQGIQVPEGFCVT TVGYQKAIEQNETLQVLLDQLTMLKVEDRDQIGNISRKIRQIIMEVDIPSDVVKAVAQ YLSQFGEEHAYAVRSSATAEDLPHASFAGQQDTYLNITGVDAILQHISKCWASLFTDR AVIYRMQNGFDHSQVYLSVIVQRMVFPQASGILFTADPITSNRKVLSIDAGFGLGEAL VSGLVSADCFKVQDGQIIDKRIATKKMAIYGRKEGGTETQQIDSDQQKAQTLTDEQIL QLARIGRQIEAHFGQPQDIEWCLARDTFYIVQSRPITTLFPIPEASDQENHVYISVGH QQMMTDPIKPLGLSFFLLTTVAPMRKAGGRLFVDVTHHLASPDSREVFLKGMGQHDQL LKDALMTIIKRRDFIKSIPNDKTAPNPSRGNADMPAQVENDPTIVSDLIESSQTSIEE LKQNIQTKSGSDLFRFILEDIQELKKILFNPKSSVLIRTAMNASLWINEKMNEWLGEK NAADTLSQSVPHNITSEMGLALLDVADVIRPYPEVIDYLQHVKDDNFLDELAKFDGGS KTRDAIYDYLSKYGMRCTGEIDITRTRWSEKPTTLVPMILNNIKNFEPNVGHRKFEQG RQEALKKEQELLDRLKQLPDGEQKAKETKRAIDIIRNFSGFREYPKYGMVNRYFVYKQ ALLKEAEQLIEAGVIHEKEDIYYLTFEELHEVVRTHKLDYQIISTRKDEYTLYEKLSP PRVITSDGEIVTGEYKRENLPAGAIVGLPVSSGVIEGRARVILNMEDADLEDGDILVT SFTDPSWTPLFVSIKGLVTEVGGLMTHGAVIAREYGLPAVVGVENAAKLIKDGQRIRV HGTEGYIEIF*" /label="yppS CDS" gene complement(1878809..1881409) /gene="yppS" /locus_tag="BSU_18830" /old_locus_tag="BSU18830" /label="yppS gene" S_feature complement(1881410..1881519) /Source="Nicolas_S_feature" /locus_tag="new_2053930_2054039_c" /HighExp="dia15, BC, S6, SMMPr, H2O2, S5, T-5.40H, S4, HPh, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S707" promotor_-35 1881435..1881442 /Source="Nicolas_upshift_promotors" /id="U1523" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=585 /SigmaFactorBS="ctcattctacatctccccttcaaaaaaaaaTATTGACAagag cttcctagcaGGATATAATAAAATTATAAGatggatatctataactttttaactagaa a" /listShort="S708" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1881457..1881476 /Source="Nicolas_upshift_promotors" /id="U1523" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=585 /SigmaFactorBS="ctcattctacatctccccttcaaaaaaaaaTATTGACAagag cttcctagcaGGATATAATAAAATTATAAGatggatatctataactttttaactagaa a" /listShort="S708" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1881465..1882092 /Source="Nicolas_S_feature" /locus_tag="new_2053985_2054612" /HighExp="T5.0H, T4.0H, T3.30H, T3.0H, S1, T2.30H, Heat, S2, T-5.40H, C30" /AntisenseName="xynA" /AntisenseCor="-0.30871986344497798" /AntisenseRegPval="-6.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S708" upshifts 1881465 /Source="Nicolas_upshifts" /id="U1523" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=585 /SigmaFactorBS="ctcattctacatctccccttcaaaaaaaaaTATTGACAagag cttcctagcaGGATATAATAAAATTATAAGatggatatctataactttttaactagaa a" /listShort="S708" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1881509..1881528) /Source="Nicolas_upshift_promotors" /id="U1524" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.41958041958042" /psig="0.999000999001" /xcortree=1451 /SigmaFactorBS="acctggtgaaatttcccaggttctttttatATTGCACaaaaa cagacacggTGATATAATCACACTACGTGcgctttctagttaaaaagttatagatatc c" /listShort="S707, pps" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1881519) /Source="Nicolas_upshifts" /id="U1524" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.41958041958042" /psig="0.999000999001" /xcortree=1451 /SigmaFactorBS="acctggtgaaatttcccaggttctttttatATTGCACaaaaa cagacacggTGATATAATCACACTACGTGcgctttctagttaaaaagttatagatatc c" /listShort="S707, pps" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1881543..1881549) /Source="Nicolas_upshift_promotors" /id="U1524" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.41958041958042" /psig="0.999000999001" /xcortree=1451 /SigmaFactorBS="acctggtgaaatttcccaggttctttttatATTGCACaaaaa cagacacggTGATATAATCACACTACGTGcgctttctagttaaaaagttatagatatc c" /listShort="S707, pps" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1881565..1882024) /Source="Nicolas_S_feature" /locus_tag="new_2054085_2054544_c" /HighExp="S0, Lbstat, HiTm, dia0, ferm, Lbexp, T1.0H, M0t45, LBGtran, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="SigA" /TUlongPSig="0.985" /label="S709" downshifts complement(1881607) /Source="Nicolas_upshifts" /id="D1028" /incds=0 /nref=87 /ntot=200 /MaxReadThrough="1.89557" /MaxDrop="5.26144" /score="1.97345986" /energy="-10.4" /TU="NA" /idTUdmin="U1525" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1882069) /Source="Nicolas_upshifts" /id="D1029" /incds=0 /nref=2 /ntot=26 /MaxReadThrough="5.28207" /MaxDrop="3.16026" /score="1.97345986" /energy="-10.4" /TU="U1525" /idTUdmin="U1525" /TUdmin="-462" /isTUend="FALSE" /label="downshifts" CDS complement(1882079..1882720) /gene="xynA" /locus_tag="BSU_18840" /old_locus_tag="BSU18840" /EC_number="3.2.1.8" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7704256, 8628241, 16517552, 26559526" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7704256, 8628241, 16517552, 26559526; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="secreted endo-1,4-beta-xylanase" /protein_id="NP_389765.1" /db_xref="EnsemblGenomes-Gn:BSU18840" /db_xref="EnsemblGenomes-Tr:CAB13776" /db_xref="GOA:P18429" /db_xref="InterPro:IPR001137" /db_xref="InterPro:IPR013319" /db_xref="InterPro:IPR013320" /db_xref="InterPro:IPR018208" /db_xref="InterPro:IPR033119" /db_xref="InterPro:IPR033123" /db_xref="PDB:1AXK" /db_xref="PDB:1XXN" /db_xref="PDB:2B42" /db_xref="PDB:2B45" /db_xref="PDB:2B46" /db_xref="PDB:2DCY" /db_xref="PDB:2DCZ" /db_xref="PDB:2QZ3" /db_xref="PDB:2Z79" /db_xref="PDB:3EXU" /db_xref="PDB:3HD8" /db_xref="PDB:5K9Y" /db_xref="SubtiList:BG10808" /db_xref="UniProtKB/Swiss-Prot:P18429" /translation="MFKFKKNFLVGLSAALMSISLFSATASAASTDYWQNWTDGGGIV NAVNGSGGNYSVNWSNTGNFVVGKGWTTGSPFRTINYNAGVWAPNGNGYLTLYGWTRS PLIEYYVVDSWGTYRPTGTYKGTVKSDGGTYDIYTTTRYNAPSIDGDRTTFTQYWSVR QSKRPTGSNATITFSNHVNAWKSHGMNLGSNWAYQVMATEGYQSSGSSNVTVW*" /label="xynA CDS" gene complement(1882079..1882720) /gene="xynA" /locus_tag="BSU_18840" /old_locus_tag="BSU18840" /label="xynA gene" S_feature complement(1882721..1882838) /Source="Nicolas_S_feature" /locus_tag="new_2055241_2055358_c" /HighExp="S0, HiTm, T1.0H, Gly, Lbstat, SMMPr, Lbtran, LBGstat, SMM, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="SigA" /TUlongPSig="0.985" /label="S710" promotor_-10 complement(1882815..1882834) /Source="Nicolas_upshift_promotors" /id="U1525" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.656343656343656" /psig="0.995004995004995" /xcortree=2292 /SigmaFactorBS="ttataatgtgtttctaggtatttgtaattgaattacaaatac ttttaaTATttgctcatgaattCGTGGTATTATACTGAAGGGgacgatcaaaagcttt g" /listShort="S710, xynA, S709" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1882838) /Source="Nicolas_upshifts" /id="U1525" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.656343656343656" /psig="0.995004995004995" /xcortree=2292 /SigmaFactorBS="ttataatgtgtttctaggtatttgtaattgaattacaaatac ttttaaTATttgctcatgaattCGTGGTATTATACTGAAGGGgacgatcaaaagcttt g" /listShort="S710, xynA, S709" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1882848..1882850) /Source="Nicolas_upshift_promotors" /id="U1525" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.656343656343656" /psig="0.995004995004995" /xcortree=2292 /SigmaFactorBS="ttataatgtgtttctaggtatttgtaattgaattacaaatac ttttaaTATttgctcatgaattCGTGGTATTATACTGAAGGGgacgatcaaaagcttt g" /listShort="S710, xynA, S709" /GFF_Attribute="listLong" /label="promotor_-35" SCAR join(1882926,1882933) /created_by="User" /note="deletion occured in betwen marked nucleotides" /modified_by="User" /label="IIG_Bs05" N_region 1882927..1882932 /note="SacI site (GAGCTC)" /modified_by="User" /label="IIG_Bs05" misc_RNA <1882933..1883017 /gene="bsrF" /locus_tag="BSU_misc_RNA_75" /product="small untranslated regulatory RNA" /experiment="publication(s) with functional evidences, PMID:18948176, 19542274" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18948176, 19542274; Product type n: RNA" /label="bsrF RNA" S_feature <1882933..1883010 /Source="Nicolas_S_feature" /locus_tag="new_2079086_2079196" /HighExp="LoTm, S7, HPh, LPhT, S8, BT, S6, G/S, S0, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH" /TUshortPSig="0.896, 1" /TUlongSig="SigEF" /TUlongPSig="0.995" /label="S728" S_feature complement(<1882933..1882997) /Source="Nicolas_S_feature" /locus_tag="new_2078548_2079183_c" /HighExp="MG 150, S8, MG 120, S7, MG 90, GM-0.1, Glu, Fru, GM-0.2, GM 5" /AntisenseName="yobO" /AntisenseCor="0.134597835896198" /AntisenseRegPval="-1.6" /CDS_PredictionProba="0.40121099999999998" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S726" gene <1882933..1883017 /gene="bsrF" /old_locus_tag="BSU_misc_RNA_75" /locus_tag="PG10_pseudo_BSU_misc_RNA_75" /modified_by="User" /label="PG10_pseudo_BSU_misc_RNA_75" downshifts 1882995 /Source="Nicolas_upshifts" /id="D1044" /incds=0 /nref=65 /ntot=254 /MaxReadThrough="1.60135" /MaxDrop="9.06442" /score="30.7999406" /energy="-13.9" /TU="NA" /idTUdmin="U1545" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS complement(1883028..1883360) /gene="csaA" /locus_tag="BSU_19040" /old_locus_tag="BSU19040" /function="16.1: Circulate" /function="16.6: Maintain" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10658654, 10816431, 13129613, 15856219, 17372352, 28724440; Product type f : factor" /codon_start=1 /transl_table=11 /product="molecular chaperone for secreting proteins" /protein_id="NP_389785.1" /db_xref="EnsemblGenomes-Gn:BSU19040" /db_xref="EnsemblGenomes-Tr:CAB13796" /db_xref="GOA:P37584" /db_xref="InterPro:IPR002547" /db_xref="InterPro:IPR008231" /db_xref="InterPro:IPR012340" /db_xref="PDB:2NZH" /db_xref="PDB:2NZO" /db_xref="SubtiList:BG10809" /db_xref="UniProtKB/Swiss-Prot:P37584" /translation="MAVIDDFEKLDIRTGTIVKAEEFPEARVPAIKLVIDFGTEIGIK QSSAQITKRYKPEGLINKQVIAVVNFPPRRIAGFKSEVLVLGGIPGQGDVVLLQPDQP VPNGTKIG*" /label="csaA CDS" gene complement(1883028..1883360) /gene="csaA" /locus_tag="BSU_19040" /old_locus_tag="BSU19040" /label="csaA gene" downshifts complement(1883042) /Source="Nicolas_upshifts" /id="D1045" /incds=0 /nref=28 /ntot=228 /MaxReadThrough="4.42209" /MaxDrop="5.706" /score="-8.98970984" /energy="-13.9" /TU="U1547" /idTUdmin="U1550" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1883425..1884150) /gene="yobQ" /locus_tag="BSU_19050" /old_locus_tag="BSU19050" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10704478, 27038276; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (AraC/XylS family)" /protein_id="NP_389786.1" /db_xref="EnsemblGenomes-Gn:BSU19050" /db_xref="EnsemblGenomes-Tr:CAB13797" /db_xref="GOA:O34901" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR013096" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR018060" /db_xref="InterPro:IPR018062" /db_xref="SubtiList:BG13508" /db_xref="UniProtKB/Swiss-Prot:O34901" /translation="MLMDSLQEIICEKRTYTRLYHSHKHAYSQFLFPLEGSIDLETEG RQVKLNPDHFLYIPPQCEHRFRSIGRNECLVLDVPLHAMKIDEYRAGSGIEAALDPFW SSIRYLLTEEAKAGTANSLHMLVQYIKEKLQSHSYASIAYIHSHLFERLTIKKLAEIE HYHPAYYSSWFKKQTGKSPQNYIADLRLEEAKRMLMERNETLTVVSEALGFQNLSSFT RWFTKSTGMPPRLYRNTLYSDKK*" /label="yobQ CDS" gene complement(1883425..1884150) /gene="yobQ" /locus_tag="BSU_19050" /old_locus_tag="BSU19050" /label="yobQ gene" CDS complement(1884165..1884908) /gene="yobR" /locus_tag="BSU_19060" /old_locus_tag="BSU19060" /EC_number="2.3.1.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12793527, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_389787.1" /db_xref="EnsemblGenomes-Gn:BSU19060" /db_xref="EnsemblGenomes-Tr:CAB13798" /db_xref="GOA:O34376" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13509" /db_xref="UniProtKB/Swiss-Prot:O34376" /translation="MDDIRKIERLAAASWPAYFQKSIGKWLLRANFGVTKRANSVWTS ADMPEGDFQLEAELFYQSLGLPVCFHISNASPKGLDDALADSRYEKVDECFQMTALCR SIMSRTNDNSRFTYKWEQEPSSVWIDEFIQLEGFSPERHKGYKHIFERMPPCKTFFKM YDKESLTALGTVSVIDGYGGLSNIVVAEEHRGKGAGTQVIRVLTEWAKNNGAERMFLQ VMKENLAAVSLYGKIGFSPISEHHYRIKR*" /label="yobR CDS" gene complement(1884165..1884908) /gene="yobR" /locus_tag="BSU_19060" /old_locus_tag="BSU19060" /label="yobR gene" promotor_-10 complement(1884936..1884955) /Source="Nicolas_upshift_promotors" /id="U1547" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.273726273726274" /psig="0.997002997002997" /xcortree=3044 /SigmaFactorBS="ttattaataaacaataaaaatattatgtaaacaaataaatGG ATGTCttatatttctgaaTATTGTATAATATCAAGGGAgtatacataggggagaggca t" /listShort="yobR, yobQ, csaA, S726" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1884955) /Source="Nicolas_upshifts" /id="U1547" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.273726273726274" /psig="0.997002997002997" /xcortree=3044 /SigmaFactorBS="ttattaataaacaataaaaatattatgtaaacaaataaatGG ATGTCttatatttctgaaTATTGTATAATATCAAGGGAgtatacataggggagaggca t" /listShort="yobR, yobQ, csaA, S726" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1884969..1884975) /Source="Nicolas_upshift_promotors" /id="U1547" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.273726273726274" /psig="0.997002997002997" /xcortree=3044 /SigmaFactorBS="ttattaataaacaataaaaatattatgtaaacaaataaatGG ATGTCttatatttctgaaTATTGTATAATATCAAGGGAgtatacataggggagaggca t" /listShort="yobR, yobQ, csaA, S726" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1884986..1885561) /gene="yobS" /locus_tag="BSU_19070" /old_locus_tag="BSU19070" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_389788.1" /db_xref="EnsemblGenomes-Gn:BSU19070" /db_xref="EnsemblGenomes-Tr:CAB13799" /db_xref="GOA:O34892" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR025996" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG13510" /db_xref="UniProtKB/Swiss-Prot:O34892" /translation="MSPRIGLTQKMIVDAAAEIADQEGVNGVSLAALSKKMNVRPPSL YNHINGLQAIRAELAVRGLTKLFDQMADSVTERKGDSAMLSLAHAYVDFAIENPGYYE AALLKVHDKRTEIVSDQIVCLVTKLLIENGYASEKTAIHATRGLRSLLHGFTVLIAKE AFEREEDILESLSFSIRTFLSGLLINNKNIM*" /label="yobS CDS" gene complement(1884986..1885561) /gene="yobS" /locus_tag="BSU_19070" /old_locus_tag="BSU19070" /label="yobS gene" CDS complement(1885567..1886268) /gene="yobT" /locus_tag="BSU_19080" /old_locus_tag="BSU19080" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent hydrolase" /protein_id="NP_389789.1" /db_xref="EnsemblGenomes-Gn:BSU19080" /db_xref="EnsemblGenomes-Tr:CAB13800" /db_xref="GOA:O34910" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG13511" /db_xref="UniProtKB/Swiss-Prot:O34910" /translation="MRITQYQTVWQLTFFPALFPVNCYLVEEENEVTLIDAALPGSYK GIIQAVNQLGKPLQHILLTHAHGDHVGSLDTLAQTFPHAKVMISERDSFLLQGDTSLR QDEPQTPIKGGIPKHIQTKPHQLLTGGETIGSLLAIPTPGHTPGSMSFLDTRNGTLIA GDAFQLRGGIAVSGQIKWAFPFPAFATWNKEEAIKSAQLLADKAPSCLAVGHGKFLRS PSERMRQAIQKAKKG*" /label="yobT CDS" gene complement(1885567..1886268) /gene="yobT" /locus_tag="BSU_19080" /old_locus_tag="BSU19080" /label="yobT gene" promotor_-10 complement(1886298..1886317) /Source="Nicolas_upshift_promotors" /id="U1548" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=2198 /SigmaFactorBS="cgataaaaaaataataaacTCTTGAAAaactaatggtgttaG TTAATAATAAAACTAACACcattagtttttgttaggaggaataaaaagatgagaatta c" /listShort="yobT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1886298) /Source="Nicolas_upshifts" /id="U1548" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=2198 /SigmaFactorBS="cgataaaaaaataataaacTCTTGAAAaactaatggtgttaG TTAATAATAAAACTAACACcattagtttttgttaggaggaataaaaagatgagaatta c" /listShort="yobT" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1886302..1886317) /Source="Nicolas_upshift_promotors" /id="U1549" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=2199 /SigmaFactorBS="aaatgccgcagtgccacagcgagcacaagttaacatttatgt agcgataaaaaaataataaacTCTTGAAAaactaatggtgttaGTTAATAATAAAACT A" /listShort="yobT" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1886332..1886339) /Source="Nicolas_upshift_promotors" /id="U1548" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=2198 /SigmaFactorBS="cgataaaaaaataataaacTCTTGAAAaactaatggtgttaG TTAATAATAAAACTAACACcattagtttttgttaggaggaataaaaagatgagaatta c" /listShort="yobT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(1886332..1886339) /Source="Nicolas_upshift_promotors" /id="U1549" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=2199 /SigmaFactorBS="aaatgccgcagtgccacagcgagcacaagttaacatttatgt agcgataaaaaaataataaacTCTTGAAAaactaatggtgttaGTTAATAATAAAACT A" /listShort="yobT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1886342) /Source="Nicolas_upshifts" /id="U1549" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=2199 /SigmaFactorBS="aaatgccgcagtgccacagcgagcacaagttaacatttatgt agcgataaaaaaataataaacTCTTGAAAaactaatggtgttaGTTAATAATAAAACT A" /listShort="yobT" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1886345..1886827) /gene="yobU" /locus_tag="BSU_19090" /old_locus_tag="BSU19090" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative effector of transcriptional regulator" /protein_id="NP_389790.1" /db_xref="EnsemblGenomes-Gn:BSU19090" /db_xref="EnsemblGenomes-Tr:CAB13801" /db_xref="InterPro:IPR010499" /db_xref="InterPro:IPR011256" /db_xref="InterPro:IPR029442" /db_xref="SubtiList:BG13512" /db_xref="UniProtKB/Swiss-Prot:O34637" /translation="MGFSHITHLDLKRFAGLSQRTSNALEMTEERRIPALWDQLWKQD MSALLSQAEKDKSIIALYSNYEQETNGFYTFSVGTFQEYDDILPGPYENIDLPASAYA VFTSRIGPIEEIVLETWKEIWTWDKRHLRTFTGDFEMYDQNAAVPQRAQVNIYVAIKK *" /label="yobU CDS" gene complement(1886345..1886827) /gene="yobU" /locus_tag="BSU_19090" /old_locus_tag="BSU19090" /label="yobU gene" misc_feature complement(1886866..1886883) /Source="Nicolas_upshift_promotors" /id="U1550" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.334665334665335" /psig="0.334665334665335" /xcortree=1509 /SigmaFactorBS="ataaagtaaaagaaaccattcatcacatgcaaaaaatatatg aaaccTGACACACTGCTGTCAGGtttctttgtctataatcttaaaaaaaggaggagat c" /listShort="yobU, yobT, yobS, yobR, yobQ, csaA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1886870) /Source="Nicolas_upshifts" /id="U1550" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.334665334665335" /psig="0.334665334665335" /xcortree=1509 /SigmaFactorBS="ataaagtaaaagaaaccattcatcacatgcaaaaaatatatg aaaccTGACACACTGCTGTCAGGtttctttgtctataatcttaaaaaaaggaggagat c" /listShort="yobU, yobT, yobS, yobR, yobQ, csaA" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1886881..1887822) /gene="yobV" /locus_tag="BSU_19100" /old_locus_tag="BSU19100" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_389791.1" /db_xref="EnsemblGenomes-Gn:BSU19100" /db_xref="EnsemblGenomes-Tr:CAB13802" /db_xref="GOA:O34920" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR026881" /db_xref="InterPro:IPR028349" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13513" /db_xref="UniProtKB/Swiss-Prot:O34920" /translation="MKLERLLAMVVLLISKKQVQAAELAELFEVSVRTIYRDIETINR AGIPIVTSQGSGGGIGIMETYRLEREWLKEEELFAIASALQSVSSMYEPVSHSTAYQK IKHLIPEQSTQAFKHQTEKWFIDMTAWGHTEDQKTLREKISAAIDRLLTISFTYTSAS GETLLRETEPYTLVCKAGHWYLYAYCLVRNDFRFFKLNRMKDLAILHQTFIRKDIQLD TLPWDKSWYQKDRLTELVILVQPSARQRIGEWFGYDVLHCCEEDEICQAVISLPEDQW LIGFLLQFGKDIEVLQPLHIRDKVKETIHHMQKIYET*" /label="yobV CDS" gene complement(1886881..1887822) /gene="yobV" /locus_tag="BSU_19100" /old_locus_tag="BSU19100" /label="yobV gene" downshifts complement(1886914) /Source="Nicolas_upshifts" /id="D1046" /incds=0 /nref=4 /ntot=33 /MaxReadThrough="0.95712" /MaxDrop="3.62763" /score="-3.71616684" /energy="-9" /TU="NA" /idTUdmin="U1548" /TUdmin="-770" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1887852..1887871) /Source="Nicolas_upshift_promotors" /id="U1551" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.615384615384615" /psig="0.971028971028971" /xcortree=3116 /SigmaFactorBS="tatgcgaggtgtattccgccgcataatagatATGCCcaagct ttatcaaAATGTTATGATTGTTTTGTTggaaaatacaagaagaaaaggtgcgcagaat g" /listShort="yobV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1887860) /Source="Nicolas_upshifts" /id="U1551" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.615384615384615" /psig="0.971028971028971" /xcortree=3116 /SigmaFactorBS="tatgcgaggtgtattccgccgcataatagatATGCCcaagct ttatcaaAATGTTATGATTGTTTTGTTggaaaatacaagaagaaaaggtgcgcagaat g" /listShort="yobV" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1887885..1887889) /Source="Nicolas_upshift_promotors" /id="U1551" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.615384615384615" /psig="0.971028971028971" /xcortree=3116 /SigmaFactorBS="tatgcgaggtgtattccgccgcataatagatATGCCcaagct ttatcaaAATGTTATGATTGTTTTGTTggaaaatacaagaagaaaaggtgcgcagaat g" /listShort="yobV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1887893..1887902 /Source="Nicolas_upshift_promotors" /id="U1552" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1341 /SigmaFactorBS="cataacattttgataaagcttgggcatatcTATTATGCGGcg gaatacacctCGCATATGCTATGAAAACAGgggtttccccttcttttttgtgttcagt a" /listShort="S729, yobW" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1887915..1887934 /Source="Nicolas_upshift_promotors" /id="U1552" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1341 /SigmaFactorBS="cataacattttgataaagcttgggcatatcTATTATGCGGcg gaatacacctCGCATATGCTATGAAAACAGgggtttccccttcttttttgtgttcagt a" /listShort="S729, yobW" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1887923 /Source="Nicolas_upshifts" /id="U1552" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1341 /SigmaFactorBS="cataacattttgataaagcttgggcatatcTATTATGCGGcg gaatacacctCGCATATGCTATGAAAACAGgggtttccccttcttttttgtgttcagt a" /listShort="S729, yobW" /GFF_Attribute="listLong" /label="upshifts" S_feature 1887938..1888002 /Source="Nicolas_S_feature" /locus_tag="new_2084124_2084188" /HighExp="BT, S7, B36, S8, S6, Pyr, G/S, B60, Glucon, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S729" promotor_-35 1887974..1887979 /Source="Nicolas_upshift_promotors" /id="U1553" /multdbtbs="SigK" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1008 /SigmaFactorBS="cttcttttttgtgttcagtatttatttcagCTACTAtttccg accggataaGCATACACTTCTCAACGGAggggatttcacatcatgcatcttacacttc a" /listShort="yobW" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1887995..1888013 /Source="Nicolas_upshift_promotors" /id="U1553" /multdbtbs="SigK" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1008 /SigmaFactorBS="cttcttttttgtgttcagtatttatttcagCTACTAtttccg accggataaGCATACACTTCTCAACGGAggggatttcacatcatgcatcttacacttc a" /listShort="yobW" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1888004 /Source="Nicolas_upshifts" /id="U1553" /multdbtbs="SigK" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1008 /SigmaFactorBS="cttcttttttgtgttcagtatttatttcagCTACTAtttccg accggataaGCATACACTTCTCAACGGAggggatttcacatcatgcatcttacacttc a" /listShort="yobW" /GFF_Attribute="listLong" /label="upshifts" CDS 1888028..1888573 /gene="yobW" /locus_tag="BSU_19110" /old_locus_tag="BSU19110" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:8990290, 11717295, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8990290, 11717295, 15849754, 16850406; Product type f: factor" /codon_start=1 /transl_table=11 /product="mother cell-specific membrane sporulation protein" /protein_id="NP_389792.1" /db_xref="EnsemblGenomes-Gn:BSU19110" /db_xref="EnsemblGenomes-Tr:CAB13803" /db_xref="GOA:P94497" /db_xref="InterPro:IPR014743" /db_xref="SubtiList:BG12269" /db_xref="UniProtKB/Swiss-Prot:P94497" /translation="MHLTLQSVYPAIIIIFFLYKKIKRSIGYQPLKPRWLFTRIILFS LFAFGLSIFSAIHPFLYGYLILGILGGWLLVFFAKKNISFEKRRGKIYFRTHIWVEVI LLTLFLSRFLYRVTELYLTSPDLNRLGSYSQSIGTDPLTIGVCFLIAVYYIGFSSFII KLSRNELEQHEYNKEKDILAR*" /label="yobW CDS" gene 1888028..1888573 /gene="yobW" /locus_tag="BSU_19110" /old_locus_tag="BSU19110" /label="yobW gene" downshifts 1888532 /Source="Nicolas_upshifts" /id="D1047" /incds=0 /nref=20 /ntot=63 /MaxReadThrough="3.56215" /MaxDrop="4.5413" /score="-4.21976438" /energy="-17.7" /TU="U1552,U1553" /idTUdmin="U1552" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" CDS complement(1888600..1888923) /gene="czrA" /locus_tag="BSU_19120" /old_locus_tag="BSU19120" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15948947, 16406068, 16430705, 19170879, 19995076, 25213752" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15948947, 16406068, 16430705, 19170879, 19995076, 25213752; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (multiple metal-sensing ArsR-SmtB transcriptional repressor favouring Zn2+)" /protein_id="NP_389793.1" /db_xref="EnsemblGenomes-Gn:BSU19120" /db_xref="EnsemblGenomes-Tr:CAB13804" /db_xref="GOA:O31844" /db_xref="InterPro:IPR001845" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13748" /db_xref="UniProtKB/Swiss-Prot:O31844" /translation="MTEFRETEQSAADLDEETLFLVAQTFKALSDPTRIRILHLLSQG EHAVNGIAEKLNLLQSTVSHQLRFLKNLRLVKSRREGTSIYYSPEDEHVLDVLQQMIH HTQHD*" /label="czrA CDS" gene complement(1888600..1888923) /gene="czrA" /locus_tag="BSU_19120" /old_locus_tag="BSU19120" /label="czrA gene" downshifts complement(1888607) /Source="Nicolas_upshifts" /id="D1048" /incds=0 /nref=73 /ntot=252 /MaxReadThrough="1.89304" /MaxDrop="4.873" /score="17.3750937" /energy="-18.6" /TU="NA" /idTUdmin="U1554" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1888944..1888963) /Source="Nicolas_upshift_promotors" /id="U1554" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.462537462537463" /psig="0.999000999001" /xcortree=2223 /SigmaFactorBS="actatgagattgaaatggaatacaagcaggctGGTTTGCAct caagcgcattTGTTATAAGATAAAACTATGaataaagaaaggtgatacatatgactga a" /listShort="czrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1888955) /Source="Nicolas_upshifts" /id="U1554" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.462537462537463" /psig="0.999000999001" /xcortree=2223 /SigmaFactorBS="actatgagattgaaatggaatacaagcaggctGGTTTGCAct caagcgcattTGTTATAAGATAAAACTATGaataaagaaaggtgatacatatgactga a" /listShort="czrA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1888976..1888983) /Source="Nicolas_upshift_promotors" /id="U1554" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.462537462537463" /psig="0.999000999001" /xcortree=2223 /SigmaFactorBS="actatgagattgaaatggaatacaagcaggctGGTTTGCAct caagcgcattTGTTATAAGATAAAACTATGaataaagaaaggtgatacatatgactga a" /listShort="czrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1889044..1889050 /Source="Nicolas_upshift_promotors" /id="U1555" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.444555444555445" /psig="0.994005994005994" /xcortree=3129 /SigmaFactorBS="tttcaatctcatagtttaaatttatgtttcaaatcaggtttt tACTTGGTctgatataccctctTATGTCATAATAAAAAAGGTcatactgctccaaaca t" /listShort="yocA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1889061 /Source="Nicolas_upshifts" /id="U1555" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.444555444555445" /psig="0.994005994005994" /xcortree=3129 /SigmaFactorBS="tttcaatctcatagtttaaatttatgtttcaaatcaggtttt tACTTGGTctgatataccctctTATGTCATAATAAAAAAGGTcatactgctccaaaca t" /listShort="yocA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1889065..1889084 /Source="Nicolas_upshift_promotors" /id="U1555" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.444555444555445" /psig="0.994005994005994" /xcortree=3129 /SigmaFactorBS="tttcaatctcatagtttaaatttatgtttcaaatcaggtttt tACTTGGTctgatataccctctTATGTCATAATAAAAAAGGTcatactgctccaaaca t" /listShort="yocA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1889117..1889794 /gene="yocA" /locus_tag="BSU_19130" /old_locus_tag="BSU19130" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14563871, 20400549; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative murein fragments glycosidase" /protein_id="NP_389794.1" /db_xref="EnsemblGenomes-Gn:BSU19130" /db_xref="EnsemblGenomes-Tr:CAB13805" /db_xref="GOA:O34636" /db_xref="InterPro:IPR023346" /db_xref="SubtiList:BG13514" /db_xref="UniProtKB/Swiss-Prot:O34636" /translation="MKKKRKGCFAAAGFMMIFVFVIASFLLVLLFFNRDLIKKLPIDT KTIVLERLTDYKPLVEEELESQGLSNYTSLILGMMYQESKGKGNDPMQSSESLGLKRN EITDPQLSVKQGIKQFTLMYKTGKEKGVDLDTIIQSYNMGAGYIDFVAEHGGTHTEEL AKQYSEQQVKKNPDLYTCGGNAKNFRYPYCYGDYTYAEKVKEKTKTVEESLQVATLET MESKAHE*" /label="yocA CDS" gene 1889117..1889794 /gene="yocA" /locus_tag="BSU_19130" /old_locus_tag="BSU19130" /label="yocA gene" downshifts 1889786 /Source="Nicolas_upshifts" /id="D1049" /incds=0 /nref=207 /ntot=268 /MaxReadThrough="3.9729" /MaxDrop="8.52704" /score="-4.21976438" /energy="-17.7" /TU="U1555" /idTUdmin="U1555" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" CDS complement(1889884..1890420) /gene="yozB" /locus_tag="BSU_19140" /old_locus_tag="BSU19140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 19222757, 24214949; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_389795.1" /db_xref="EnsemblGenomes-Gn:BSU19140" /db_xref="EnsemblGenomes-Tr:CAB13806" /db_xref="GOA:O31845" /db_xref="InterPro:IPR007352" /db_xref="InterPro:IPR013833" /db_xref="SubtiList:BG13749" /db_xref="UniProtKB/Swiss-Prot:O31845" /translation="MNQTENKPKNYTGIVLTLTVLINGLIAVLFFMPKLDQFSHANIH ILPMLNAIFNSFTFIFLLAALIMIKQKNIKAHKRFILAAFTTTLLFLICYVTYHSIAE NTLYGGEGIMRPIYFFILITHICLSAIIVPLALFTLIRGFSMQVERHKKIARWTMPLW LYVSLTGVIVYLMISPYY*" /label="yozB CDS" gene complement(1889884..1890420) /gene="yozB" /locus_tag="BSU_19140" /old_locus_tag="BSU19140" /label="yozB gene" downshifts complement(1889907) /Source="Nicolas_upshifts" /id="D1050" /incds=0 /nref=175 /ntot=250 /MaxReadThrough="4.33842" /MaxDrop="7.96098" /score="14.7470642" /energy="-7.7" /TU="U1556" /idTUdmin="U1557" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1890447..1890466) /Source="Nicolas_upshift_promotors" /id="U1556" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.824175824175824" /psig="0.99000999000999" /xcortree=1607 /SigmaFactorBS="gcctttgaagtgtgtctaatttctgacgaagcaatcgaaaCC GTTGACatcttctttgaatTTGCATACGATTTGGATAGCcagtacaaattaggagagg t" /listShort="yozB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1890467) /Source="Nicolas_upshifts" /id="U1556" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.824175824175824" /psig="0.99000999000999" /xcortree=1607 /SigmaFactorBS="gcctttgaagtgtgtctaatttctgacgaagcaatcgaaaCC GTTGACatcttctttgaatTTGCATACGATTTGGATAGCcagtacaaattaggagagg t" /listShort="yozB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1890480..1890487) /Source="Nicolas_upshift_promotors" /id="U1556" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.824175824175824" /psig="0.99000999000999" /xcortree=1607 /SigmaFactorBS="gcctttgaagtgtgtctaatttctgacgaagcaatcgaaaCC GTTGACatcttctttgaatTTGCATACGATTTGGATAGCcagtacaaattaggagagg t" /listShort="yozB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1890557..1891339) /gene="yocB" /locus_tag="BSU_19150" /old_locus_tag="BSU19150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11717291, 16291680" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389796.1" /db_xref="EnsemblGenomes-Gn:BSU19150" /db_xref="EnsemblGenomes-Tr:CAB13807" /db_xref="SubtiList:BG13515" /db_xref="UniProtKB/Swiss-Prot:O34516" /translation="MAIDSLINKLQYVQLEPPDKILSLYLNTDMRDPEQQGGEWKIAL KSGFSRLKEYLAASDPEEEKCLDGIRAKMNQYLNAMGKDMPRSLVFFVSDSGIWEPIK LQVPVDTRFYWEETAVLDQLKGLRQTYPSTAFILTQQHEVKIIETVLGKIEAVERYEY DMINESWKNSHSAVDKAPPFEENRMREHVTENQSRLYKRLAASLDQKAAAKRWERMVI AGDKETADILDQHMNKPIHSKIQKNLLNENEHKVIEHLIKEA*" /label="yocB CDS" gene complement(1890557..1891339) /gene="yocB" /locus_tag="BSU_19150" /old_locus_tag="BSU19150" /label="yocB gene" downshifts complement(1890566) /Source="Nicolas_upshifts" /id="D1051" /incds=0 /nref=3 /ntot=38 /MaxReadThrough="5.37496" /MaxDrop="4.00348" /score="14.7470642" /energy="-7.7" /TU="U1557" /idTUdmin="U1557" /TUdmin="-660" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1891361..1891379) /Source="Nicolas_upshift_promotors" /id="U1557" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=229 /SigmaFactorBS="aaacaacaattccattattactagaaattagcggaaagtcaG GTTTGAtcgtttttaagagAGGAAAAAGAAAACTAACCtgtgaaaaaggaggaatcgg a" /listShort="yocB, yozB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1891380) /Source="Nicolas_upshifts" /id="U1557" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=229 /SigmaFactorBS="aaacaacaattccattattactagaaattagcggaaagtcaG GTTTGAtcgtttttaagagAGGAAAAAGAAAACTAACCtgtgaaaaaggaggaatcgg a" /listShort="yocB, yozB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1891393..1891399) /Source="Nicolas_upshift_promotors" /id="U1557" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=229 /SigmaFactorBS="aaacaacaattccattattactagaaattagcggaaagtcaG GTTTGAtcgtttttaagagAGGAAAAAGAAAACTAACCtgtgaaaaaggaggaatcgg a" /listShort="yocB, yozB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1891436..1891443 /Source="Nicolas_upshift_promotors" /id="U1558" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig=1 /xcortree=2435 /SigmaFactorBS="actttccgctaatttctagtaataatggaattgtTGTTTACA atacgcctctcttcTAATACAATTGGTAACTGTGtttctaagctgttttttgaaagga g" /listShort="yocC, yocD" /listLong="des, S730, desK, desR" /label="promotor_-35" promotor_-10 1891458..1891477 /Source="Nicolas_upshift_promotors" /id="U1558" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig=1 /xcortree=2435 /SigmaFactorBS="actttccgctaatttctagtaataatggaattgtTGTTTACA atacgcctctcttcTAATACAATTGGTAACTGTGtttctaagctgttttttgaaagga g" /listShort="yocC, yocD" /listLong="des, S730, desK, desR" /label="promotor_-10" upshifts 1891462 /Source="Nicolas_upshifts" /id="U1558" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig=1 /xcortree=2435 /SigmaFactorBS="actttccgctaatttctagtaataatggaattgtTGTTTACA atacgcctctcttcTAATACAATTGGTAACTGTGtttctaagctgttttttgaaagga g" /listShort="yocC, yocD" /listLong="des, S730, desK, desR" /label="upshifts" CDS 1891510..1892007 /gene="yocC" /locus_tag="BSU_19160" /old_locus_tag="BSU19160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 14563871" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389797.1" /db_xref="EnsemblGenomes-Gn:BSU19160" /db_xref="EnsemblGenomes-Tr:CAB13808" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13516" /db_xref="UniProtKB/Swiss-Prot:O35042" /translation="MFTVKEKNRQELEEELNDLEFQIYRMQENMKDLSKDAKVLGIDQ SKHDEWMIVSSIDDGQTCKIMLTDCKTAYRGKGCFSLVASYKDDAIHIGDIKGPPNHG FGSICMKYLKDIARDHNIPKVTGDIAKRDWNHVDRLIHFYEKHHFKVCIDHDTQSGSI KWVDL*" /label="yocC CDS" gene 1891510..1892007 /gene="yocC" /locus_tag="BSU_19160" /old_locus_tag="BSU19160" /label="yocC gene" promotor_-35 1892014..1892017 /Source="Nicolas_upshift_promotors" /id="U1559" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.314685314685315" /psig="0.984015984015984" /xcortree=3013 /SigmaFactorBS="caatccggcagcattaagtgggttgatttgtaaaaaagtCTG GaagaaagagccaagaTATGCTGTAATGGTATAAAAccattgatggagggttctatgt a" /listShort="yocD" /listLong="des, S730, desK, desR" /label="promotor_-35" promotor_-10 1892033..1892052 /Source="Nicolas_upshift_promotors" /id="U1559" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.314685314685315" /psig="0.984015984015984" /xcortree=3013 /SigmaFactorBS="caatccggcagcattaagtgggttgatttgtaaaaaagtCTG GaagaaagagccaagaTATGCTGTAATGGTATAAAAccattgatggagggttctatgt a" /listShort="yocD" /listLong="des, S730, desK, desR" /label="promotor_-10" upshifts 1892035 /Source="Nicolas_upshifts" /id="U1559" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.314685314685315" /psig="0.984015984015984" /xcortree=3013 /SigmaFactorBS="caatccggcagcattaagtgggttgatttgtaaaaaagtCTG GaagaaagagccaagaTATGCTGTAATGGTATAAAAccattgatggagggttctatgt a" /listShort="yocD" /listLong="des, S730, desK, desR" /label="upshifts" CDS 1892071..1893048 /gene="yocD" /locus_tag="BSU_19170" /old_locus_tag="BSU19170" /EC_number="3.4.17.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22516613; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative carboxypeptidase; aminoacid adenylate hydrolase (microcin resistance)" /protein_id="NP_389798.1" /db_xref="EnsemblGenomes-Gn:BSU19170" /db_xref="EnsemblGenomes-Tr:CAB13809" /db_xref="GOA:O35046" /db_xref="InterPro:IPR003507" /db_xref="InterPro:IPR027461" /db_xref="InterPro:IPR027478" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG13517" /db_xref="UniProtKB/Swiss-Prot:O35046" /translation="MYASKLKKGDEIRIVSPATSMSILSNEAKIQAKTALERLGYRVT IAEHANECNEFDSSSIESRVHDLHAAFFDPGVKAILTTLGGFNSNQLLRYLDYEKIKR HPKILCGYSDITALCNAIYQKTGLVTYSGPHFSTFAMKKGLDYTEEYFLSCCASDDPF EIHPSSEWSDDRWFLDQENRRFYPNNGPVVIQEGYAEGTLIGGNLCTLNLLQGTEYFP ETEHTILLIEDDYMSDIHMFDRDLQSLIHLPAFSHVKAILIGRFQKASNVSIDLVKAM IETKKELSGIPIIANINAGHTSPIATFPIGGTCRIEAISGTSRIWIDKH*" /label="yocD CDS" gene 1892071..1893048 /gene="yocD" /locus_tag="BSU_19170" /old_locus_tag="BSU19170" /label="yocD gene" downshifts 1893020 /Source="Nicolas_upshifts" /id="D1052" /incds=0 /nref=131 /ntot=256 /MaxReadThrough="3.77491" /MaxDrop="4.2254" /score="1.66373432" /energy="-9.5" /TU="U1558,U1559" /idTUdmin="U1558" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" promotor_-35 1893145..1893152 /Source="Nicolas_upshift_promotors" /id="U1560" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.503496503496504" /psig="0.85914085914086" /xcortree=311 /SigmaFactorBS="acaaatgtcatataggaggcatgatgtgtgcTACTACAAaag acttctctcatTAGCGTATACTGAACCGAGAcacacaatgagaggatacttactatga c" /listShort="des, S730, desK, desR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1893167..1893186 /Source="Nicolas_upshift_promotors" /id="U1560" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.503496503496504" /psig="0.85914085914086" /xcortree=311 /SigmaFactorBS="acaaatgtcatataggaggcatgatgtgtgcTACTACAAaag acttctctcatTAGCGTATACTGAACCGAGAcacacaatgagaggatacttactatga c" /listShort="des, S730, desK, desR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1893174 /Source="Nicolas_upshifts" /id="U1560" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.503496503496504" /psig="0.85914085914086" /xcortree=311 /SigmaFactorBS="acaaatgtcatataggaggcatgatgtgtgcTACTACAAaag acttctctcatTAGCGTATACTGAACCGAGAcacacaatgagaggatacttactatga c" /listShort="des, S730, desK, desR" /GFF_Attribute="listLong" /label="upshifts" CDS 1893210..1894268 /gene="desE" /locus_tag="BSU_19180" /old_locus_tag="BSU19180" /EC_number="1.14.19.-" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9555904, 11717295, 12207704, 15247225, 15711796, 16105701, 28546427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9555904, 11717295, 12207704, 15247225, 15711796, 16105701, 28546427; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fatty acid desaturase" /protein_id="NP_389799.1" /db_xref="EnsemblGenomes-Gn:BSU19180" /db_xref="EnsemblGenomes-Tr:CAB13810" /db_xref="GOA:O34653" /db_xref="InterPro:IPR005804" /db_xref="SubtiList:BG13518" /db_xref="UniProtKB/Swiss-Prot:O34653" /translation="MTEQTIAHKQKQLTKQVAAFAQPETKNSLIQLLNTFIPFFGLWF LAYLSLDVSYLLTLALTVIAAGFLTRIFIIFHDCCHQSFFKQKRYNHILGFLTGVLTL FPYLQWQHSHSIHHATSSNLDKRGTGDIWMLTVNEYKAASRRTKLAYRLYRNPFIMFI LGPIYVFLITNRFNKKGARRKERVNTYLTNLAIVALAAACCLIFGWQSFLLVQGPIFL ISGSIGVWLFYVQHTFEDSYFEADENWSYVQAAVEGSSFYKLPKLLQWLTGNIGYHHV HHLSPKVPNYKLEVAHEHHEPLKNVPTITLKTSLQSLAFRLWDEDNKQFVSFRAIKHI PVSLPPDSPEKQKLRKNA*" /label="desE CDS" gene 1893210..1894268 /gene="desE" /locus_tag="BSU_19180" /old_locus_tag="BSU19180" /label="desE gene" S_feature 1894269..1894338 /Source="Nicolas_S_feature" /locus_tag="new_2090455_2090524" /HighExp="Cold, S8, LoTm, Sw, Paraq, BC, S7, S0, Oxctl, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.859" /TUlongSig="SigA, SigA" /TUlongPSig="0.984, 1" /label="S730" promotor_-35 1894322..1894328 /Source="Nicolas_upshift_promotors" /id="U1561" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97002997002997" /psig="0.999000999001" /xcortree=3111 /SigmaFactorBS="gtcttctaatatactagaaggcttcctttttattgttggagg GTGCATTctggctttcacAATGATAAAGTTACAAGTAAgatgaaaagctgaaaatgag g" /listShort="desK, desR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1894340..1894359 /Source="Nicolas_upshift_promotors" /id="U1561" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97002997002997" /psig="0.999000999001" /xcortree=3111 /SigmaFactorBS="gtcttctaatatactagaaggcttcctttttattgttggagg GTGCATTctggctttcacAATGATAAAGTTACAAGTAAgatgaaaagctgaaaatgag g" /listShort="desK, desR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1894340 /Source="Nicolas_upshifts" /id="U1561" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97002997002997" /psig="0.999000999001" /xcortree=3111 /SigmaFactorBS="gtcttctaatatactagaaggcttcctttttattgttggagg GTGCATTctggctttcacAATGATAAAGTTACAAGTAAgatgaaaagctgaaaatgag g" /listShort="desK, desR" /GFF_Attribute="listLong" /label="upshifts" CDS 1894388..1895500 /gene="desK" /locus_tag="BSU_19190" /old_locus_tag="BSU19190" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11285232, 11717295, 12207704, 14734164, 15090506, 15711796, 23356219, 24574048, 26172072, 28475313" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11285232, 11717295, 12207704, 14734164, 15090506, 15711796, 23356219, 24574048, 26172072, 28475313; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component thermosensor histidine kinase [DesR-DesK]" /protein_id="NP_389800.1" /db_xref="EnsemblGenomes-Gn:BSU19190" /db_xref="EnsemblGenomes-Tr:CAB13811" /db_xref="GOA:O34757" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR036890" /db_xref="PDB:3EHF" /db_xref="PDB:3EHG" /db_xref="PDB:3EHH" /db_xref="PDB:3EHJ" /db_xref="PDB:3GIE" /db_xref="PDB:3GIF" /db_xref="PDB:3GIG" /db_xref="PDB:5IUJ" /db_xref="PDB:5IUK" /db_xref="PDB:5IUL" /db_xref="PDB:5IUM" /db_xref="PDB:5IUN" /db_xref="SubtiList:BG13519" /db_xref="UniProtKB/Swiss-Prot:O34757" /translation="MIKNHFTFQKLNGITPYIWTIFFILPFYFIWKSSSTFVIIVGII LTLLFFSVYRFAFVSKGWTIYLWGFLLIGISTASITLFSYIYFAFFIAYFIGNIKERV PFHILYYVHLISAAVAANFSLVLKKEFFLTQIPFVVITLISAILLPFSIKSRKERERL EEKLEDANERIAELVKLEERQRIARDLHDTLGQKLSLIGLKSDLARKLIYKDPEQAAR ELKSVQQTARTSLNEVRKIVSSMKGIRLKDELINIKQILEAADIMFIYEEEKWPENIS LLNENILSMCLKEAVTNVVKHSQAKTCRVDIQQLWKEVVITVSDDGTFKGEENSFSKG HGLLGMRERLEFANGSLHIDTENGTKLTMAIPNNSK*" /label="desK CDS" gene 1894388..1895500 /gene="desK" /locus_tag="BSU_19190" /old_locus_tag="BSU19190" /label="desK gene" CDS 1895519..1896118 /gene="desR" /locus_tag="BSU_19200" /old_locus_tag="BSU19200" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11285232, 11717295, 12207704, 14734164, 15090506, 15711796, 19595746, 20581210, 24574048" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11285232, 11717295, 12207704, 14734164, 15090506, 15711796, 19595746, 20581210, 24574048; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [DesK]" /protein_id="NP_389801.1" /db_xref="EnsemblGenomes-Gn:BSU19200" /db_xref="EnsemblGenomes-Tr:CAB13812" /db_xref="GOA:O34723" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="PDB:4LDZ" /db_xref="PDB:4LE0" /db_xref="PDB:4LE1" /db_xref="PDB:4LE2" /db_xref="PDB:5IUJ" /db_xref="PDB:5IUK" /db_xref="PDB:5IUL" /db_xref="PDB:5IUN" /db_xref="SubtiList:BG13520" /db_xref="UniProtKB/Swiss-Prot:O34723" /translation="MISIFIAEDQQMLLGALGSLLNLEDDMEVVGKGTTGQDAVDFVK KRQPDVCIMDIEMPGKTGLEAAEELKDTGCKIIILTTFARPGYFQRAIKAGVKGYLLK DSPSEELANAIRSVMNGKRIYAPELMEDLYSEANPLTDREKEVLELVADGKNTKEIAQ ELSIKSGTVRNYISMILEKLEVKNRIEAITRSKEKGWFK*" /label="desR CDS" gene 1895519..1896118 /gene="desR" /locus_tag="BSU_19200" /old_locus_tag="BSU19200" /label="desR gene" downshifts 1896056 /Source="Nicolas_upshifts" /id="D1053" /incds=1 /nref=1 /ntot=41 /MaxReadThrough="4.44811" /MaxDrop="2.78724" /score="23.648858" /energy="-15.4" /TU="U1560" /idTUdmin="U1560" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" downshifts 1896100 /Source="Nicolas_upshifts" /id="D1054" /incds=0 /nref=1 /ntot=68 /MaxReadThrough="1.88273" /MaxDrop="3.38398" /score="23.648858" /energy="-15.4" /TU="NA" /idTUdmin="U1560" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1896140..1896638) /Source="Nicolas_S_feature" /locus_tag="new_2092326_2092824_c" /HighExp="S4, LoTm, S6, S3, S5, S8, S7, B36, T5.0H, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.230296" /TUshortSig="SigEF" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S731" downshifts complement(1896176) /Source="Nicolas_upshifts" /id="D1055" /incds=0 /nref=3 /ntot=21 /MaxReadThrough="1.62146" /MaxDrop="5.61121" /score="23.7393309" /energy="-12.4" /TU="NA" /idTUdmin="U1563" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1896610..1896619 /Source="Nicolas_upshift_promotors" /id="U1562" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1329 /SigmaFactorBS="tcttttaacccgagagcccctgaatcgcacataaagaaaAAC GGGACCActttcttttatcAGCATATGATATAAACAGCTctaagcagaacaaaaaaag a" /listShort="S732, S733" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1896622..1896640) /Source="Nicolas_upshift_promotors" /id="U1563" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1169 /SigmaFactorBS="ataaaagacataagcttttggcttgtgtctttttttGTTCTG cttagagctgtttataTCATATGCTGATAAAAGAAagtggtcccgtttttctttatgt g" /listShort="S731" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1896631..1896825 /Source="Nicolas_S_feature" /locus_tag="new_2092817_2093011" /HighExp="S6, S8, S7, BT, B36, Pyr, G/S, C30, S5, B60" /AntisenseName="yocH" /AntisenseCor="0.113870403460631" /AntisenseRegPval="-1.2" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S732" upshifts 1896631 /Source="Nicolas_upshifts" /id="U1562" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1329 /SigmaFactorBS="tcttttaacccgagagcccctgaatcgcacataaagaaaAAC GGGACCActttcttttatcAGCATATGATATAAACAGCTctaagcagaacaaaaaaag a" /listShort="S732, S733" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1896632..1896651 /Source="Nicolas_upshift_promotors" /id="U1562" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1329 /SigmaFactorBS="tcttttaacccgagagcccctgaatcgcacataaagaaaAAC GGGACCActttcttttatcAGCATATGATATAAACAGCTctaagcagaacaaaaaaag a" /listShort="S732, S733" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1896638) /Source="Nicolas_upshifts" /id="U1563" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1169 /SigmaFactorBS="ataaaagacataagcttttggcttgtgtctttttttGTTCTG cttagagctgtttataTCATATGCTGATAAAAGAAagtggtcccgtttttctttatgt g" /listShort="S731" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1896657..1896662) /Source="Nicolas_upshift_promotors" /id="U1563" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1169 /SigmaFactorBS="ataaaagacataagcttttggcttgtgtctttttttGTTCTG cttagagctgtttataTCATATGCTGATAAAAGAAagtggtcccgtttttctttatgt g" /listShort="S731" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1896713..1897576) /gene="walL" /locus_tag="BSU_19210" /old_locus_tag="BSU19210" /EC_number="3.2.1.-" /function="16.6: Maintain" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:17307850, 20070526, 20487291, 26102633" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17307850, 20070526, 20487291, 26102633; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported cell wall lytic enzyme" /protein_id="NP_389802.1" /db_xref="EnsemblGenomes-Gn:BSU19210" /db_xref="EnsemblGenomes-Tr:CAB13813" /db_xref="GOA:O34669" /db_xref="InterPro:IPR010611" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="InterPro:IPR036908" /db_xref="SubtiList:BG13521" /db_xref="UniProtKB/Swiss-Prot:O34669" /translation="MKKTIMSFVAVAALSTTAFGAHASAKEITVQKGDTLWGISQKNG VNLKDLKEWNKLTSDKIIAGEKLTISSEETTTTGQYTIKAGDTLSKIAQKFGTTVNNL KVWNNLSSDMIYAGSTLSVKGQATAANTATENAQTNAPQAAPKQEAVQKEQPKQEAVQ QQPKQETKAEAETSVNTEEKAVQSNTNNQEASKELTVTATAYTANDGGISGVTATGID LNKNPNAKVIAVDPNVIPLGSKVYVEGYGEATAADTGGAIKGNKIDVFVPSKSDASNW GVKTVSVKVLN*" /label="walL CDS" gene complement(1896713..1897576) /gene="walL" /locus_tag="BSU_19210" /old_locus_tag="BSU19210" /label="walL gene" downshifts complement(1896726) /Source="Nicolas_upshifts" /id="D1056" /incds=0 /nref=227 /ntot=262 /MaxReadThrough="2.55593" /MaxDrop="7.59881" /score="23.8272007" /energy="-10.2" /TU="U1565" /idTUdmin="U1565" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" downshifts 1896782 /Source="Nicolas_upshifts" /id="D1057" /incds=1 /nref=8 /ntot=28 /MaxReadThrough="6.14664" /MaxDrop="3.95582" /score="23.648858" /energy="-15.4" /TU="U1562" /idTUdmin="U1560" /TUdmin=682 /isTUend="FALSE" /label="downshifts" downshifts complement(1896814) /Source="Nicolas_upshifts" /id="D1058" /incds=1 /nref=10 /ntot=161 /MaxReadThrough="7.34609" /MaxDrop="3.8459" /score="23.8272007" /energy="-10.2" /TU="U1565" /idTUdmin="U1565" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" S_feature 1896827..1897594 /Source="Nicolas_S_feature" /locus_tag="new_2093013_2093780" /HighExp="BT, S8, S6, Gly, S7, C30, G135, G/S, Fru, Pyr" /AntisenseName="yocH" /AntisenseCor="-0.12155468325348801" /AntisenseRegPval="-1.3" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S733" promotor_-35 1897572..1897576 /Source="Nicolas_upshift_promotors" /id="U1564" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=1239 /SigmaFactorBS="agtgcagcaactgccacaaaggacataatcgtcttcTTCATa agtaaatCCTCCCTTGTTAGCTttttattggcggctaacaggtgatatcgtaacacac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1897585..1897599 /Source="Nicolas_upshift_promotors" /id="U1564" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=1239 /SigmaFactorBS="agtgcagcaactgccacaaaggacataatcgtcttcTTCATa agtaaatCCTCCCTTGTTAGCTttttattggcggctaacaggtgatatcgtaacacac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1897596 /Source="Nicolas_upshifts" /id="U1564" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=1239 /SigmaFactorBS="agtgcagcaactgccacaaaggacataatcgtcttcTTCATa agtaaatCCTCCCTTGTTAGCTttttattggcggctaacaggtgatatcgtaacacac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1897615..1897634) /Source="Nicolas_upshift_promotors" /id="U1565" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig="0.999000999001" /xcortree=582 /SigmaFactorBS="gtaaaggaactgtaatctaaatcatatctttttgttATTGAT TtgacatttacgTGTGTTACGATATCACCTGTtagccgccaataaaaagctaacaagg g" /listShort="yocH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1897628) /Source="Nicolas_upshifts" /id="U1565" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig="0.999000999001" /xcortree=582 /SigmaFactorBS="gtaaaggaactgtaatctaaatcatatctttttgttATTGAT TtgacatttacgTGTGTTACGATATCACCTGTtagccgccaataaaaagctaacaagg g" /listShort="yocH" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1897630..1897823) /Source="Nicolas_S_feature" /locus_tag="new_2093816_2094009_c" /HighExp="LoTm, HiOs, S8, C30, S2, G135, G180, T5.0H, S7, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S734" promotor_-35 complement(1897646..1897652) /Source="Nicolas_upshift_promotors" /id="U1565" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig="0.999000999001" /xcortree=582 /SigmaFactorBS="gtaaaggaactgtaatctaaatcatatctttttgttATTGAT TtgacatttacgTGTGTTACGATATCACCTGTtagccgccaataaaaagctaacaagg g" /listShort="yocH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1897824..1899599) /gene="recQ" /locus_tag="BSU_19220" /old_locus_tag="BSU19220" /EC_number="3.6.1.12" /experiment="publication(s) with functional evidences, PMID:11886746, 16385024, 22200572, 25246477, 26001966" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11886746, 16385024, 22200572, 25246477, 26001966; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent helicase" /protein_id="NP_389803.1" /db_xref="EnsemblGenomes-Gn:BSU19220" /db_xref="EnsemblGenomes-Tr:CAB13814" /db_xref="GOA:O34748" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR002121" /db_xref="InterPro:IPR004589" /db_xref="InterPro:IPR006293" /db_xref="InterPro:IPR010997" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR018982" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032284" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13522" /db_xref="UniProtKB/Swiss-Prot:O34748" /translation="MLHRAQSLLAHYFGYEKFRSGQDEAIRLVTEARQNTACIMPTGG GKSICYQIPALMFEGTTIVISPLISLMKDQVDALEEAGINAAYINSTQSNQEIYERLN GLKEGAYKLFYITPERLTSIEFIRILQGIDVPLVAIDEAHCISQWGHDFRPSYRNIEI LFRELHDKPVIMALTATATPEVHDDICKQLHIQKENTVYTGFSRENLTFKVVKGENKD RFIDEYVQNNRHEAGIVYTATRKEADRIYERLKRNQVRAGRYHGGLADDVRKEQQERF LNDELQVMVATSAFGMGIDKSNIRFVLHAQIPKDMESYYQEAGRAGRDGLASECVLLF SPQDIMVQRFLIEQSEHEEKQKQDLKKLRQMVDYCHTEDCLQRFILMYFGEKEPDACG QCGNCTDTRAAHDVTREAQMVLSCIIRMKERFGKTMVAQVLAGSKNKKVLENGFSDLS TYGILKHQSVGEISDFIEFLISDDFIRMSDGTFPTLFVSSKGRNVLKGELSVARKEAL KAAAITENDELFERLRMVRKEIAAEQGVPPFVVFSDQTLKEMSGKQPVNDDELLSIKG VGEQKRAKYGRLFLQEIQAYARMTD*" /label="recQ CDS" gene complement(1897824..1899599) /gene="recQ" /locus_tag="BSU_19220" /old_locus_tag="BSU19220" /label="recQ gene" S_feature complement(1899600..1899730) /Source="Nicolas_S_feature" /locus_tag="new_2095786_2095916_c" /HighExp="LoTm, G180, Cold, G135, G150, T5.0H, T4.0H, T3.30H, S2, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S735" misc_RNA complement(1899723..1899925) /gene="ssrSA" /locus_tag="BSU_misc_RNA_32" /product="6Sa RNA" /experiment="publication(s) with functional evidences, PMID:11886746, 15793584, 15811922, 22333917, 25576829, 26873600" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11886746, 15793584, 15811922, 22333917, 25576829, 26873600; Product type n : RNA" /label="ssrSA RNA" gene complement(1899723..1899925) /gene="ssrSA" /locus_tag="BSU_misc_RNA_32" /label="ssrSA gene" downshifts complement(1899775) /Source="Nicolas_upshifts" /id="D1059" /incds=0 /nref=34 /ntot=297 /MaxReadThrough="4.06142" /MaxDrop="7.97725" /score="26.8190437" /energy="-12.7" /TU="U1566" /idTUdmin="U1568" /TUdmin=163 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1899923..1899942) /Source="Nicolas_upshift_promotors" /id="U1566" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.554445554445554" /psig=1 /xcortree=418 /SigmaFactorBS="attcactggaaaaagtttttctaaacaattgttctgaccTCT TGATTaaaagcgcctgaTGGTGTACTATATTAAAGAAgctactttgtgcgtattgtta a" /listShort="NA, S735, yocI, S734" /listLong="yocH" /label="promotor_-10" upshifts complement(1899941) /Source="Nicolas_upshifts" /id="U1566" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.554445554445554" /psig=1 /xcortree=418 /SigmaFactorBS="attcactggaaaaagtttttctaaacaattgttctgaccTCT TGATTaaaagcgcctgaTGGTGTACTATATTAAAGAAgctactttgtgcgtattgtta a" /listShort="NA, S735, yocI, S734" /listLong="yocH" /label="upshifts" S_feature complement(1899943..1900135) /Source="Nicolas_S_feature" /locus_tag="new_2096129_2096321_c" /HighExp="dia5, Etha, dia15, Diami, S8, S7, C30, G180, G135, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S736" promotor_-35 complement(1899955..1899962) /Source="Nicolas_upshift_promotors" /id="U1566" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.554445554445554" /psig=1 /xcortree=418 /SigmaFactorBS="attcactggaaaaagtttttctaaacaattgttctgaccTCT TGATTaaaagcgcctgaTGGTGTACTATATTAAAGAAgctactttgtgcgtattgtta a" /listShort="NA, S735, yocI, S734" /listLong="yocH" /label="promotor_-35" CDS complement(1900164..1900790) /gene="azoJ" /locus_tag="BSU_19230" /old_locus_tag="BSU19230" /EC_number="1.7.-.-" /experiment="publication(s) with functional evidences, PMID:11886746, 18208493, 22200572" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11886746, 18208493, 22200572; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="FMN-dependent NADH-azoreductase" /protein_id="NP_389804.1" /db_xref="EnsemblGenomes-Gn:BSU19230" /db_xref="EnsemblGenomes-Tr:CAB13815" /db_xref="GOA:O35022" /db_xref="InterPro:IPR003680" /db_xref="InterPro:IPR023048" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG13523" /db_xref="UniProtKB/Swiss-Prot:O35022" /translation="MSTVLFVKSSDRTAEEGVSTKLYEAFLAAYKENNPNDEVVELDL HKENLPYLGRDMINGTFKAGQGMEMTEDEKKQAAIADKYLNQFVKADKVVFAFPLWNF TVPAVLHTYVDYLSRAGVTFKYTQEGPVGLMGGKKVALLNARGGVYSEGPMAALEMSL NFMKTVLGFWGVQDLHTVVIEGHNAAPDQAQEIVEKGLQEAKDLAAKF*" /label="azoJ CDS" gene complement(1900164..1900790) /gene="azoJ" /locus_tag="BSU_19230" /old_locus_tag="BSU19230" /label="azoJ gene" downshifts complement(1900180) /Source="Nicolas_upshifts" /id="D1060" /incds=0 /nref=68 /ntot=205 /MaxReadThrough="5.10353" /MaxDrop="5.66408" /score="1.15982687" /energy="-10.9" /TU="U1567,U1568" /idTUdmin="U1567" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1900824..1900843) /Source="Nicolas_upshift_promotors" /id="U1567" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.682317682317682" /psig=1 /xcortree=1846 /SigmaFactorBS="tttgaaaaaaaatctcatattcaaaataaagtgATTGACTTt acgtaaaaaagaAAGTAACATACTATTTGTAAgtaaatataaaaagtttaccgggagg a" /listShort="yocJ, S736" /listLong="NA, S735, yocI, S734, yocH" /label="promotor_-10" upshifts complement(1900837) /Source="Nicolas_upshifts" /id="U1567" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.682317682317682" /psig=1 /xcortree=1846 /SigmaFactorBS="tttgaaaaaaaatctcatattcaaaataaagtgATTGACTTt acgtaaaaaagaAAGTAACATACTATTTGTAAgtaaatataaaaagtttaccgggagg a" /listShort="yocJ, S736" /listLong="NA, S735, yocI, S734, yocH" /label="upshifts" promotor_-35 complement(1900857..1900864) /Source="Nicolas_upshift_promotors" /id="U1567" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.682317682317682" /psig=1 /xcortree=1846 /SigmaFactorBS="tttgaaaaaaaatctcatattcaaaataaagtgATTGACTTt acgtaaaaaagaAAGTAACATACTATTTGTAAgtaaatataaaaagtttaccgggagg a" /listShort="yocJ, S736" /listLong="NA, S735, yocI, S734, yocH" /label="promotor_-35" CDS complement(1900941..1901432) /gene="yocK" /locus_tag="BSU_19240" /old_locus_tag="BSU19240" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10220166, 15496987, 15496987; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative general stress protein" /protein_id="NP_389805.2" /db_xref="EnsemblGenomes-Gn:BSU19240" /db_xref="EnsemblGenomes-Tr:CAB13816" /db_xref="GOA:P80872" /db_xref="InterPro:IPR000962" /db_xref="InterPro:IPR020458" /db_xref="InterPro:IPR037187" /db_xref="SubtiList:BG13524" /db_xref="UniProtKB/Swiss-Prot:P80872" /translation="MALTKEQTQHLYHKLLDMQKELSGEKKETESMTEEVGELSNGVD NHMADHGTLVTDRMTDQTVKEIDRELLEEVNRALQKMKDGTYGVCEKTGQEIPYERLE AVPYARMTVEAQADVEDDLETDAPSYEREFHEQVKDLSNKETIDQKSSQTYEILDREQ DSK*" /label="yocK CDS" gene complement(1900941..1901432) /gene="yocK" /locus_tag="BSU_19240" /old_locus_tag="BSU19240" /label="yocK gene" downshifts complement(1900950) /Source="Nicolas_upshifts" /id="D1061" /incds=0 /nref=5 /ntot=49 /MaxReadThrough="7.79466" /MaxDrop="4.30433" /score="1.15982687" /energy="-10.9" /TU="U1568,U1573" /idTUdmin="U1571" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1901444..1901462) /Source="Nicolas_upshift_promotors" /id="U1568" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=238 /SigmaFactorBS="aaggcagtagctcatctttccatcgatgtttccaTGTTTGAc agaaggcaaaacGGGAAACAGGATAGAAAGGagaggatatacatggcactgacaaaag a" /listShort="yocK, yocJ, S736" /listLong="NA" /label="promotor_-10" upshifts complement(1901456) /Source="Nicolas_upshifts" /id="U1568" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=238 /SigmaFactorBS="aaggcagtagctcatctttccatcgatgtttccaTGTTTGAc agaaggcaaaacGGGAAACAGGATAGAAAGGagaggatatacatggcactgacaaaag a" /listShort="yocK, yocJ, S736" /listLong="NA" /label="upshifts" promotor_-35 complement(1901476..1901482) /Source="Nicolas_upshift_promotors" /id="U1568" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=238 /SigmaFactorBS="aaggcagtagctcatctttccatcgatgtttccaTGTTTGAc agaaggcaaaacGGGAAACAGGATAGAAAGGagaggatatacatggcactgacaaaag a" /listShort="yocK, yocJ, S736" /listLong="NA" /label="promotor_-35" CDS complement(1901507..1901839) /gene="yocL" /locus_tag="BSU_19250" /old_locus_tag="BSU19250" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 21926231" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389806.1" /db_xref="EnsemblGenomes-Gn:BSU19250" /db_xref="EnsemblGenomes-Tr:CAB13817" /db_xref="SubtiList:BG13525" /db_xref="UniProtKB/Swiss-Prot:O34976" /translation="MKKMFRSLIRHCLKPELDKLRECEERLSVIEKQKQSSKQESEET YIHIETLNVEKVDYHLEFGELTIDELSGRLNIGATYYIPPEEKDKKCQRKPEAPSTPA VTIRSKRQ*" /label="yocL CDS" gene complement(1901507..1901839) /gene="yocL" /locus_tag="BSU_19250" /old_locus_tag="BSU19250" /label="yocL gene" S_feature complement(1901840..1902130) /Source="Nicolas_S_feature" /locus_tag="new_2098025_2098315_c" /HighExp="Salt, Cold, S3, S8, S4, S7, T5.0H, T3.30H, S6, T4.0H" /AntisenseName="yoyB" /AntisenseCor="0.489341986454357" /AntisenseRegPval="-16.899999999999999" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA, SigWXY" /TUshortPSig="0.698, 0.799, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S737" promotor_-35 1901855..1901860 /Source="Nicolas_upshift_promotors" /id="U1569" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.877122877122877" /psig="0.877122877122877" /xcortree=1142 /SigmaFactorBS="agcgaccggaacatttttttcatgacatcacgacccttTGCA TActcctctttcgtctACATATATAATGAGGTATAtcccatagaaaggagaggttttc a" /listShort="yoyB, S738" /listLong="yozN, yocN" /label="promotor_-35" promotor_-10 1901875..1901893 /Source="Nicolas_upshift_promotors" /id="U1569" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.877122877122877" /psig="0.877122877122877" /xcortree=1142 /SigmaFactorBS="agcgaccggaacatttttttcatgacatcacgacccttTGCA TActcctctttcgtctACATATATAATGAGGTATAtcccatagaaaggagaggttttc a" /listShort="yoyB, S738" /listLong="yozN, yocN" /label="promotor_-10" upshifts 1901877 /Source="Nicolas_upshifts" /id="U1569" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.877122877122877" /psig="0.877122877122877" /xcortree=1142 /SigmaFactorBS="agcgaccggaacatttttttcatgacatcacgacccttTGCA TActcctctttcgtctACATATATAATGAGGTATAtcccatagaaaggagaggttttc a" /listShort="yoyB, S738" /listLong="yozN, yocN" /label="upshifts" CDS 1901917..1902144 /gene="yoyB" /locus_tag="BSU_19259" /old_locus_tag="BSU19259" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 19383706, 20709900" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097740.1" /db_xref="EnsemblGenomes-Gn:BSU19259" /db_xref="EnsemblGenomes-Tr:CAX52637" /db_xref="UniProtKB/Swiss-Prot:C0H429" /translation="MLPTNINISHLKTNSIGTGSSLTFGSAELRNRCSAIKRNNGFGE QNADGIVMVIPIESIDDRDVSDALSMKINHQ*" /label="yoyB CDS" gene 1901917..1902144 /gene="yoyB" /locus_tag="BSU_19259" /old_locus_tag="BSU19259" /label="yoyB gene" CDS complement(1902131..1902607) /gene="yocM" /locus_tag="BSU_19260" /old_locus_tag="BSU19260" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11150673, 23155385; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative chaperone" /protein_id="NP_389808.1" /db_xref="EnsemblGenomes-Gn:BSU19260" /db_xref="EnsemblGenomes-Tr:CAB13818" /db_xref="InterPro:IPR002068" /db_xref="InterPro:IPR008978" /db_xref="InterPro:IPR031107" /db_xref="SubtiList:BG13526" /db_xref="UniProtKB/Swiss-Prot:O34321" /translation="MDFEKMKQWMEFAQQMYGGDFWKQVFDEDQKTPFMTNGQSPFPF AQQDQRGKGDASFPSMDIVDTVAEVQFLIYLPGYRKQDVHILSYGDYLVVKGQRFSYF NEQDFRQKEGKYGSFEKKIPLSDHLHGKMNAIFKDGILYITIQKDEGQAKTIVIDD*" /label="yocM CDS" gene complement(1902131..1902607) /gene="yocM" /locus_tag="BSU_19260" /old_locus_tag="BSU19260" /label="yocM gene" S_feature 1902145..1902652 /Source="Nicolas_S_feature" /locus_tag="new_2098330_2098837" /HighExp="S6, S5, S8, S7, S4, B36, BT, S3, T5.0H, LoTm" /AntisenseName="yocM" /AntisenseCor="0.54530996552252997" /AntisenseRegPval="-21.5" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.877" /TUlongSig="NA" /TUlongPSig="NA" /label="S738" S_feature complement(1902608..1902710) /Source="Nicolas_S_feature" /locus_tag="new_2098793_2098895_c" /HighExp="Cold, Salt, S8, T5.0H, S3, T-0.40H, T0.0H, S4, T4.0H, S6" /AntisenseName="yozN" /AntisenseCor="0.471443110130365" /AntisenseRegPval="-15.6" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA, SigWXY" /TUshortPSig="0.698, 0.799, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S739" promotor_-35 1902625..1902630 /Source="Nicolas_upshift_promotors" /id="U1570" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1089 /SigmaFactorBS="ttttcgaaatccatttgaagccccctgtcttAACATActtta taaccgccaGCATACAACTATAGAAAGGaggtttgcctgtggttcaaccaactccgta t" /listShort="yozN, yocN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1902645..1902663 /Source="Nicolas_upshift_promotors" /id="U1570" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1089 /SigmaFactorBS="ttttcgaaatccatttgaagccccctgtcttAACATActtta taaccgccaGCATACAACTATAGAAAGGaggtttgcctgtggttcaaccaactccgta t" /listShort="yozN, yocN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1902654 /Source="Nicolas_upshifts" /id="U1570" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1089 /SigmaFactorBS="ttttcgaaatccatttgaagccccctgtcttAACATActtta taaccgccaGCATACAACTATAGAAAGGaggtttgcctgtggttcaaccaactccgta t" /listShort="yozN, yocN" /GFF_Attribute="listLong" /label="upshifts" CDS 1902674..1902937 /gene="yozN" /locus_tag="BSU_19270" /old_locus_tag="BSU19270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20709900" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (mother cell in sporulation)" /protein_id="NP_389809.1" /db_xref="EnsemblGenomes-Gn:BSU19270" /db_xref="EnsemblGenomes-Tr:CAB13819" /db_xref="SubtiList:BG13761" /db_xref="UniProtKB/Swiss-Prot:O31846" /translation="MVQPTPYININIFMLKINSFENASAVNVGQNLLAEWQNSDKKNQ GYGQNFGDASGFMGTRSHVDDRDQIDSPASFESEAVNSSIKRK*" /label="yozN CDS" gene 1902674..1902937 /gene="yozN" /locus_tag="BSU_19270" /old_locus_tag="BSU19270" /label="yozN gene" promotor_-10 complement(1902690..1902709) /Source="Nicolas_upshift_promotors" /id="U1571" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.698301698301698" /psig="0.698301698301698" /xcortree=1042 /SigmaFactorBS="ataaattttgtcctacgttaaccgctgaagcattttcaaagg aATTAAttttcagcatgaaAATATTAATATTGATATACGgagttggttgaaccacagg c" /listShort="S739, yocM, S737, yocL, yocK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1902710) /Source="Nicolas_upshifts" /id="U1571" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.698301698301698" /psig="0.698301698301698" /xcortree=1042 /SigmaFactorBS="ataaattttgtcctacgttaaccgctgaagcattttcaaagg aATTAAttttcagcatgaaAATATTAATATTGATATACGgagttggttgaaccacagg c" /listShort="S739, yocM, S737, yocL, yocK" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1902712..1903237) /Source="Nicolas_S_feature" /locus_tag="new_2098897_2099422_c" /HighExp="Salt, Cold, T-0.40H, T0.0H, T0.30H, T-1.10H, T-1.40H, T3.30H, T2.0H, S0" /AntisenseName="yocN" /AntisenseCor="-0.51964820699949898" /AntisenseRegPval="-19.3" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY" /TUshortPSig="0.799, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S740" promotor_-35 complement(1902723..1902727) /Source="Nicolas_upshift_promotors" /id="U1571" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.698301698301698" /psig="0.698301698301698" /xcortree=1042 /SigmaFactorBS="ataaattttgtcctacgttaaccgctgaagcattttcaaagg aATTAAttttcagcatgaaAATATTAATATTGATATACGgagttggttgaaccacagg c" /listShort="S739, yocM, S737, yocL, yocK" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1902942..1903175 /gene="yocN" /locus_tag="BSU_19280" /old_locus_tag="BSU19280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20709900" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (sporulation-related)" /protein_id="NP_389810.1" /db_xref="EnsemblGenomes-Gn:BSU19280" /db_xref="EnsemblGenomes-Tr:CAB13820" /db_xref="SubtiList:BG13527" /db_xref="UniProtKB/Swiss-Prot:O34855" /translation="MFFSPSVVNVGGFKINTMDRGSSLTLGPYQQVDYFLSAKINQGF GEENGDFTPLVVPISNVLDADLVDSNSAKNSVV*" /label="yocN CDS" gene 1902942..1903175 /gene="yocN" /locus_tag="BSU_19280" /old_locus_tag="BSU19280" /label="yocN gene" downshifts 1903162 /Source="Nicolas_upshifts" /id="D1062" /incds=0 /nref=62 /ntot=90 /MaxReadThrough="2.0117" /MaxDrop="7.59451" /score="5.68120132" /energy="-10.9" /TU="NA" /idTUdmin="U1570" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1903261..1903605) /gene="yozO" /locus_tag="BSU_19290" /old_locus_tag="BSU19290" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 23155385" /codon_start=1 /transl_table=11 /product="conserved hypothetical phage protein" /protein_id="NP_389811.1" /db_xref="EnsemblGenomes-Gn:BSU19290" /db_xref="EnsemblGenomes-Tr:CAB13821" /db_xref="InterPro:IPR011993" /db_xref="InterPro:IPR012544" /db_xref="InterPro:IPR037063" /db_xref="SubtiList:BG13762" /db_xref="UniProtKB/Swiss-Prot:O31847" /translation="MGIFSVSRSTDAKKLEALLVEGERIESIYKLRVDQICFTNKRII FFDNKMFSKKKVRVFLPYKTIESFAIQEAGMFDPDTGLLLMTRSKTFELEFAKDTDLS EVQAVLTKHLCS*" /label="yozO CDS" gene complement(1903261..1903605) /gene="yozO" /locus_tag="BSU_19290" /old_locus_tag="BSU19290" /label="yozO gene" downshifts complement(1903282) /Source="Nicolas_upshifts" /id="D1063" /incds=0 /nref=61 /ntot=217 /MaxReadThrough="4.58642" /MaxDrop="4.1868" /score="12.6520239" /energy="-9.6" /TU="U1572,U1573" /idTUdmin="U1574" /TUdmin=616 /isTUend="FALSE" /label="downshifts" S_feature complement(1903606..1903678) /Source="Nicolas_S_feature" /locus_tag="new_2099791_2099863_c" /HighExp="T0.30H, T0.0H, T1.0H, T-0.40H, T1.30H, T-1.10H, Salt, T2.0H, T-1.40H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY" /TUshortPSig="0.799, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S741" promotor_-10 complement(1903674..1903693) /Source="Nicolas_upshift_promotors" /id="U1572" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.421578421578422" /psig="0.7992007992008" /xcortree=1714 /SigmaFactorBS="aatttgaaaaatgtaatctgttcgtaATGGTTtaaatgtctt ctaTGTCGTATTCTTATATAGGGataaaggacttatttttatgtagtgaatgataaaa c" /listShort="S741, yozO, S740, S739, yocM, S737, yocL, yocK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1903678) /Source="Nicolas_upshifts" /id="U1572" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.421578421578422" /psig="0.7992007992008" /xcortree=1714 /SigmaFactorBS="aatttgaaaaatgtaatctgttcgtaATGGTTtaaatgtctt ctaTGTCGTATTCTTATATAGGGataaaggacttatttttatgtagtgaatgataaaa c" /listShort="S741, yozO, S740, S739, yocM, S737, yocL, yocK" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1903680..1903783) /Source="Nicolas_S_feature" /locus_tag="new_2099865_2099968_c" /HighExp="T0.30H, T0.0H, T-0.40H, T1.0H, T1.30H, Salt, T-1.10H, T2.0H, T-1.40H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S742" promotor_-35 complement(1903707..1903712) /Source="Nicolas_upshift_promotors" /id="U1572" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.421578421578422" /psig="0.7992007992008" /xcortree=1714 /SigmaFactorBS="aatttgaaaaatgtaatctgttcgtaATGGTTtaaatgtctt ctaTGTCGTATTCTTATATAGGGataaaggacttatttttatgtagtgaatgataaaa c" /listShort="S741, yozO, S740, S739, yocM, S737, yocL, yocK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1903770..1903785) /Source="Nicolas_upshift_promotors" /id="U1573" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1697 /SigmaFactorBS="taaaaaccacttttttataaaaacattgctgaatatTGAAAC TTTTttctctatatgtGCGTATTACTTGATGAcaacagcttaaaagccaaaaaacaaa t" /listShort="S742, S741, yozO, S740, S739, yocM, S737, yocL, yocK, yocJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1903783) /Source="Nicolas_upshifts" /id="U1573" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1697 /SigmaFactorBS="taaaaaccacttttttataaaaacattgctgaatatTGAAAC TTTTttctctatatgtGCGTATTACTTGATGAcaacagcttaaaagccaaaaaacaaa t" /listShort="S742, S741, yozO, S740, S739, yocM, S737, yocL, yocK, yocJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1903798..1903807) /Source="Nicolas_upshift_promotors" /id="U1573" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1697 /SigmaFactorBS="taaaaaccacttttttataaaaacattgctgaatatTGAAAC TTTTttctctatatgtGCGTATTACTTGATGAcaacagcttaaaagccaaaaaacaaa t" /listShort="S742, S741, yozO, S740, S739, yocM, S737, yocL, yocK, yocJ" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1903926) /Source="Nicolas_upshifts" /id="D1064" /incds=0 /nref=117 /ntot=269 /MaxReadThrough="5.5406" /MaxDrop="6.72115" /score="36.7697843" /energy="-10.7" /TU="U1574" /idTUdmin="U1576" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" CDS complement(1903962..1904165) /gene="yozC" /locus_tag="BSU_19300" /old_locus_tag="BSU19300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389812.1" /db_xref="EnsemblGenomes-Gn:BSU19300" /db_xref="EnsemblGenomes-Tr:CAB13822" /db_xref="SubtiList:BG13750" /db_xref="UniProtKB/Swiss-Prot:O31848" /translation="MIHKNWLEKETIKKVKCVQTNAKKYIVNRVLTPGKEYEVKNETE EFLFVVDNTNKVGGYYKEYFEEM*" /label="yozC CDS" gene complement(1903962..1904165) /gene="yozC" /locus_tag="BSU_19300" /old_locus_tag="BSU19300" /label="yozC gene" promotor_-10 complement(1904186..1904205) /Source="Nicolas_upshift_promotors" /id="U1574" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=2988 /SigmaFactorBS="ataatagaaatcaaggcaaaatcaatgaataaccgaTATTGC AAtttacaaaagaaaaaAGCTACAATAAGCTTATAGAtaagaaaaggagatttcatca t" /listShort="yozC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1904204) /Source="Nicolas_upshifts" /id="U1574" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=2988 /SigmaFactorBS="ataatagaaatcaaggcaaaatcaatgaataaccgaTATTGC AAtttacaaaagaaaaaAGCTACAATAAGCTTATAGAtaagaaaaggagatttcatca t" /listShort="yozC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1904206..1904272) /Source="Nicolas_S_feature" /locus_tag="new_2100391_2100457_c" /HighExp="S7, S8, S6, S5, C30, S4, T4.0H, B60, BC, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.461" /TUlongSig="NA" /TUlongPSig="NA" /label="S743" promotor_-35 complement(1904221..1904228) /Source="Nicolas_upshift_promotors" /id="U1574" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=2988 /SigmaFactorBS="ataatagaaatcaaggcaaaatcaatgaataaccgaTATTGC AAtttacaaaagaaaaaAGCTACAATAAGCTTATAGAtaagaaaaggagatttcatca t" /listShort="yozC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1904238..1904245 /Source="Nicolas_upshift_promotors" /id="U1575" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.59040959040959" /psig="0.96103896103896" /xcortree=509 /SigmaFactorBS="attgtagcttttttcttttgtaaattgcaatatcggttattC ATTGATTttgccttgatttcTATTATAGAATGTTTGTATAcgcttacgtttgaagcaa c" /listShort="S744, dhaS, sqhC" /listLong="sodF" /label="promotor_-35" upshifts 1904257 /Source="Nicolas_upshifts" /id="U1575" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.59040959040959" /psig="0.96103896103896" /xcortree=509 /SigmaFactorBS="attgtagcttttttcttttgtaaattgcaatatcggttattC ATTGATTttgccttgatttcTATTATAGAATGTTTGTATAcgcttacgtttgaagcaa c" /listShort="S744, dhaS, sqhC" /listLong="sodF" /label="upshifts" misc_feature complement(1904259..1904271) /Source="Nicolas_upshift_promotors" /id="U1576" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.406593406593407" /psig="0.460539460539461" /xcortree=1224 /SigmaFactorBS="atagcacattgattcctggattgaatagcagaaataagctgt gatagttgcttcaaacgtaagcgtatacaaACATTCTATAATAgaaatcaaggcaaaa t" /listShort="S743, yozC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 1904259..1904278 /Source="Nicolas_upshift_promotors" /id="U1575" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.59040959040959" /psig="0.96103896103896" /xcortree=509 /SigmaFactorBS="attgtagcttttttcttttgtaaattgcaatatcggttattC ATTGATTttgccttgatttcTATTATAGAATGTTTGTATAcgcttacgtttgaagcaa c" /listShort="S744, dhaS, sqhC" /listLong="sodF" /label="promotor_-10" S_feature 1904262..1904394 /Source="Nicolas_S_feature" /locus_tag="new_2100447_2100579" /HighExp="BC, M0t90, M9-stat, S2, T2.30H, Sw, Lbstat, M40t90, T4.0H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.961" /TUlongSig="NA" /TUlongPSig="NA" /label="S744" upshifts complement(1904283) /Source="Nicolas_upshifts" /id="U1576" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.406593406593407" /psig="0.460539460539461" /xcortree=1224 /SigmaFactorBS="atagcacattgattcctggattgaatagcagaaataagctgt gatagttgcttcaaacgtaagcgtatacaaACATTCTATAATAgaaatcaaggcaaaa t" /listShort="S743, yozC" /GFF_Attribute="listLong" /label="upshifts" CDS 1904395..1905882 /gene="dhaS" /locus_tag="BSU_19310" /old_locus_tag="BSU19310" /EC_number="1.2.1.3" /function="16.11: Scavenge (Catabolism)" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:17555270, 23874669, 25409630, 26337367, 27797724" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17555270, 23874669, 25409630, 26337367, 27797724; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-hydroxypropionaldehyde dehydrogenase" /protein_id="NP_389813.1" /db_xref="EnsemblGenomes-Gn:BSU19310" /db_xref="EnsemblGenomes-Tr:CAB13823" /db_xref="GOA:O34660" /db_xref="InterPro:IPR012394" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG12582" /db_xref="UniProtKB/Swiss-Prot:O34660" /translation="MSSLTMQVTKRLETFLQGTKKLYIDGKFVPSASGATFDTPNPAT GETLMTLYEAQAADVDKAVKAARKAFDQGEWRTMSPASRSRLMYKLADLMEEHKTELA QLETLDNGKPINETTNGDIPLAIEHMRYYAGWCTKITGQTIPVSGAYFNYTRHEPVGV VGQIIPWNFPLLMAMWKMGAALATGCTIVLKPAEQTPLSALYLAELIDQAGFPAGVIN IIPGFGEDAGEALTNHEAVDKIAFTGSTEIGKKIMSTAAKSIKRVTLELGGKSPNILL PDANLKKAIPGALNGVMFNQGQVCCAGSRVFIHKDQYDEVVDEMASYAESLRQGAGLH KDTQIGPLVSKEQHERVLSYIQKGKDEGAKAVTGGSCPFEAGYFVAPTVFANVEDEMT IAKEEIFGPVLTAIPYETVDEVIERANHSEYGLAAGLWTENVKQAHYIADRLQAGTVW VNCYNVFDAASPFGGYKQSGLGREMGSYALDNYTEVKSVWVNLED*" /label="dhaS CDS" gene 1904395..1905882 /gene="dhaS" /locus_tag="BSU_19310" /old_locus_tag="BSU19310" /label="dhaS gene" promotor_-10 complement(1904838..1904855) /Source="Nicolas_upshift_promotors" /id="U1577" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.526473526473527" /psig="0.526473526473527" /xcortree=656 /SigmaFactorBS="cgggaaattccatggaatgatctggccgACGACACCGacagg ctcatgaCGCGTATAATTAAAATAAgcgccggaaaccggaatcgtctgtcctgttatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1904844) /Source="Nicolas_upshifts" /id="U1577" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.526473526473527" /psig="0.526473526473527" /xcortree=656 /SigmaFactorBS="cgggaaattccatggaatgatctggccgACGACACCGacagg ctcatgaCGCGTATAATTAAAATAAgcgccggaaaccggaatcgtctgtcctgttatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1904868..1904876) /Source="Nicolas_upshift_promotors" /id="U1577" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.526473526473527" /psig="0.526473526473527" /xcortree=656 /SigmaFactorBS="cgggaaattccatggaatgatctggccgACGACACCGacagg ctcatgaCGCGTATAATTAAAATAAgcgccggaaaccggaatcgtctgtcctgttatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1905868 /Source="Nicolas_upshifts" /id="D1065" /incds=0 /nref=163 /ntot=260 /MaxReadThrough="3.66831" /MaxDrop="7.01026" /score="24.6079855" /energy="-7.1" /TU="U1575" /idTUdmin="U1575" /TUdmin="-1144" /isTUend="FALSE" /label="downshifts" promotor_-35 1905930..1905935 /Source="Nicolas_upshift_promotors" /id="U1578" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=1130 /SigmaFactorBS="aaaactgctgcctgccagcagtttttttctttctGTAATGgc agtaaaagacgctGAATATATATGCTTCTGAAggagttgagcgtgatgggcacacttc a" /listShort="sqhC, sodF, S745" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1905951..1905969 /Source="Nicolas_upshift_promotors" /id="U1578" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=1130 /SigmaFactorBS="aaaactgctgcctgccagcagtttttttctttctGTAATGgc agtaaaagacgctGAATATATATGCTTCTGAAggagttgagcgtgatgggcacacttc a" /listShort="sqhC, sodF, S745" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1905956 /Source="Nicolas_upshifts" /id="U1578" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=1130 /SigmaFactorBS="aaaactgctgcctgccagcagtttttttctttctGTAATGgc agtaaaagacgctGAATATATATGCTTCTGAAggagttgagcgtgatgggcacacttc a" /listShort="sqhC, sodF, S745" /GFF_Attribute="listLong" /label="upshifts" CDS 1905983..1907881 /gene="sqhC" /locus_tag="BSU_19320" /old_locus_tag="BSU19320" /EC_number="4.2.1.137" /EC_number="5.4.99.17" /function="16.13: Shape" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2253626, 18436644, 18630919, 21627333" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2253626, 18436644, 18630919, 21627333; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="squalene-hopene cyclase, sporulenol synthase (spore protection)" /protein_id="NP_389814.2" /db_xref="EnsemblGenomes-Gn:BSU19320" /db_xref="EnsemblGenomes-Tr:CAB13824" /db_xref="GOA:Q796C3" /db_xref="InterPro:IPR008930" /db_xref="InterPro:IPR018333" /db_xref="InterPro:IPR032696" /db_xref="InterPro:IPR032697" /db_xref="SubtiList:BG12679" /db_xref="UniProtKB/Swiss-Prot:Q796C3" /translation="MGTLQEKVRRFQKKTITELRDRQNADGSWTFCFEGPIMTNSFFI LLLTSLDEGENEKELISSLAAGIHAKQQPDGTFINYPDETRGNLTATVQGYVGMLASG CFHRTEPHMKKAEQFIISHGGLRHVHFMTKWMLAANGLYPWPALYLPLSLMALPPTLP IHFYQFSSYARIHFAPMAVTLNQRFVLINRNISSLHHLDPHMTKNPFTWLRSDAFEER DLTSILLHWKRVFHAPFAFQQLGLQTAKTYMLDRIEKDGTLYSYASATIYMVYSLLSL GVSRYSPIIRRAITGIKSLVTKCNGIPYLENSTSTVWDTALISYALQKNGVTETDGSV TKAADFLLERQHTKIADWSVKNPNSVPGGWGFSNINTNNPDCDDTTAVLKAIPRNHSP AAWERGVSWLLSMQNNDGGFSAFEKNVNHPLIRLLPLESAEDAAVDPSTADLTGRVLH FLGEKVGFTEKHQHIQRAVKWLFEHQEQNGSWYGRWGVCYIYGTWAALTGMHACGVDR KHPGIQKALRWLKSIQNDDGSWGESCKSAEIKTYVPLHRGTIVQTAWALDALLTYENS EHPSVVKGMQYLTDSSSHSADSLAYPAGIGLPKQFYIRYHSYPYVFSLLAVGKYLDSI EKETANET*" /label="sqhC CDS" gene 1905983..1907881 /gene="sqhC" /locus_tag="BSU_19320" /old_locus_tag="BSU19320" /label="sqhC gene" promotor_-10 complement(1906926..1906945) /Source="Nicolas_upshift_promotors" /id="U1579" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1383 /SigmaFactorBS="ctgcttttgtaacagagccatccgttTCGGTCACACcatttt tttgaagGGCATAGCTTATTAAAGCTGtatcccaaacagttgaagtagagttttccag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1906934) /Source="Nicolas_upshifts" /id="U1579" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1383 /SigmaFactorBS="ctgcttttgtaacagagccatccgttTCGGTCACACcatttt tttgaagGGCATAGCTTATTAAAGCTGtatcccaaacagttgaagtagagttttccag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1906959..1906968) /Source="Nicolas_upshift_promotors" /id="U1579" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1383 /SigmaFactorBS="ctgcttttgtaacagagccatccgttTCGGTCACACcatttt tttgaagGGCATAGCTTATTAAAGCTGtatcccaaacagttgaagtagagttttccag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1907871..1908716 /gene="sodF" /locus_tag="BSU_19330" /old_locus_tag="BSU19330" /EC_number="1.15.1.1" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 17114254, 20233928; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="superoxide dismutase (Fe2+-dependent)" /protein_id="NP_389815.1" /db_xref="EnsemblGenomes-Gn:BSU19330" /db_xref="EnsemblGenomes-Tr:CAB13825" /db_xref="GOA:O35023" /db_xref="InterPro:IPR001189" /db_xref="InterPro:IPR019831" /db_xref="InterPro:IPR019832" /db_xref="InterPro:IPR019833" /db_xref="InterPro:IPR036314" /db_xref="InterPro:IPR036324" /db_xref="SubtiList:BG12676" /db_xref="UniProtKB/Swiss-Prot:O35023" /translation="MKRESYQAEMFNWCEALKDQIQKRGQLDQFEDQIDKMIEALEDD QTTEEDWYKQAAALYRDITESDDTSERRAYVPIGKHVLPKLPYKYSALEPYISRDIMI LHHTKHHQSYVDGLNKAESELKKARATKNYDLITHWERELAFHGAGHYLHSIFWFSMH PNGKRRPTGALFQMIDLSFGSYSAFKEHFTQASKKVEGVGWAILVWAPRSGRLEILTA EKHQLFSQWDVIPLLPLDVWEHAYYLQYKNDRASYVDHWWNVVDWREAEKRFEQAKEV VWKLY*" /label="sodF CDS" gene 1907871..1908716 /gene="sodF" /locus_tag="BSU_19330" /old_locus_tag="BSU19330" /label="sodF gene" S_feature 1908717..1910223 /Source="Nicolas_S_feature" /locus_tag="new_2104902_2106408" /HighExp="S5, S6, S4, S8, S3, S7, T5.0H, B36, BT, T4.0H" /AntisenseName="yocR" /AntisenseCor="-0.62866346519731298" /AntisenseRegPval="-30.3" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S745" CDS complement(1908749..1910086) /gene="yocR" /locus_tag="BSU_19340" /old_locus_tag="BSU19340" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 17114254, 27766092; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sodium-dependent transporter" /protein_id="NP_389816.1" /db_xref="EnsemblGenomes-Gn:BSU19340" /db_xref="EnsemblGenomes-Tr:CAB13826" /db_xref="GOA:O34383" /db_xref="InterPro:IPR000175" /db_xref="SubtiList:BG13528" /db_xref="UniProtKB/Swiss-Prot:O34383" /translation="MKEANQWSSKLGFILAAAGSAIGLGAIWKFPYVAGTSGGGAFLL IFILFTVLIGLPLLLGEFIIGRRTQKDAVQSYKTLAPGTKWHWIGYLGMVTCFILLSF YSVVGGWILIYIIKGFTGGLSQTSGFDTIFASTISNPYLAVGGQLLFMVVTILVVAKG VSSGIEKASQVLMPALFLLFIILMVRSVTLDGAMEGIKFFLMPDLTAIDANTILYAMG QSFFLLSVGVSVMVTYSAYLEKQENLVQSAVSVTVMNMLVAVMAGIAIFPAVFSFGLK PDQGPVLLFNVLPTVFNQMPFGIIFLLAFLLLFLFAALTSAFSMLEILVAVLSKGDIN KRKRFAWLGGIAIFIVGVPSALSYGVLSDVTIFHLSIFDAADYLVSNILMPLGALLIS IFVPLKIPKQDLFDELKSGSNLKRKWFAVWLLLIRYLSPVAIIIVFLHVIGIF*" /label="yocR CDS" gene complement(1908749..1910086) /gene="yocR" /locus_tag="BSU_19340" /old_locus_tag="BSU19340" /label="yocR gene" downshifts complement(1908760) /Source="Nicolas_upshifts" /id="D1066" /incds=0 /nref=1 /ntot=50 /MaxReadThrough="0.83968" /MaxDrop="2.44824" /score="27.8372036" /energy="-11.1" /TU="NA" /idTUdmin="U1580" /TUdmin=154 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1910114..1910133) /Source="Nicolas_upshift_promotors" /id="U1580" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2402 /SigmaFactorBS="tctatagatatatgatgtaaactaattaaaatgtTCTTGACT atataggaagatatTCTTACAATGAACCTTTATAatggttagatcaaataggagtgat a" /listShort="yocR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1910129) /Source="Nicolas_upshifts" /id="U1580" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2402 /SigmaFactorBS="tctatagatatatgatgtaaactaattaaaatgtTCTTGACT atataggaagatatTCTTACAATGAACCTTTATAatggttagatcaaataggagtgat a" /listShort="yocR" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1910131..1911289) /Source="Nicolas_S_feature" /locus_tag="new_2106316_2107474_c" /HighExp="M9-stat, T1.30H, B60, T1.0H, T2.0H, T0.30H, T2.30H, T3.0H, T3.30H, Etha" /AntisenseName="yocS" /AntisenseCor="-6.3575129468026695E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S746" promotor_-35 complement(1910148..1910155) /Source="Nicolas_upshift_promotors" /id="U1580" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2402 /SigmaFactorBS="tctatagatatatgatgtaaactaattaaaatgtTCTTGACT atataggaagatatTCTTACAATGAACCTTTATAatggttagatcaaataggagtgat a" /listShort="yocR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1910207..1910210 /Source="Nicolas_upshift_promotors" /id="U1581" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.611388611388611" /psig=1 /xcortree=2909 /SigmaFactorBS="ttagtttacatcatatatctatagacatctgccaaaaactaa TATTgaattattcagaaaATTATTTATAATAAGAGAATgttatgaaatttgtaagaat t" /listShort="yocS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1910225..1910244 /Source="Nicolas_upshift_promotors" /id="U1581" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.611388611388611" /psig=1 /xcortree=2909 /SigmaFactorBS="ttagtttacatcatatatctatagacatctgccaaaaactaa TATTgaattattcagaaaATTATTTATAATAAGAGAATgttatgaaatttgtaagaat t" /listShort="yocS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1910225 /Source="Nicolas_upshifts" /id="U1581" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.611388611388611" /psig=1 /xcortree=2909 /SigmaFactorBS="ttagtttacatcatatatctatagacatctgccaaaaactaa TATTgaattattcagaaaATTATTTATAATAAGAGAATgttatgaaatttgtaagaat t" /listShort="yocS" /GFF_Attribute="listLong" /label="upshifts" CDS 1910305..1911270 /gene="yocS" /locus_tag="BSU_19350" /old_locus_tag="BSU19350" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 27766092; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sodium-dependent symporter" /protein_id="NP_389817.1" /db_xref="EnsemblGenomes-Gn:BSU19350" /db_xref="EnsemblGenomes-Tr:CAB13827" /db_xref="GOA:O34524" /db_xref="InterPro:IPR002657" /db_xref="InterPro:IPR004710" /db_xref="SubtiList:BG13529" /db_xref="UniProtKB/Swiss-Prot:O34524" /translation="MDIIRKISHFAGQTFGIWVIVFAVLGFSFPSLFTWISSYITIFL GIIMFGMGLTLQADDFKELVRKPWQVIIGVIAQYTIMPLVAFGLAFGLHLPAEIAVGV ILVGCCPGGTASNVMTFLAKGNTALSVAVTTISTLLAPVVTPLLIMLFAKEWLPVSPG SLFISILQAVLFPIIAGLIVKMFFRKQVAKAVHALPLVSVIGIVAIVSAVVSGNRENL LQSGLLIFSVVILHNGIGYLLGFLCAKLLKMDYPSQKAIAIEVGMQNSGLGAALATAH FSPLSAVPSAIFSVWHNLSGSMLATYWSKKVKKKQAGSKSSNLSL*" /label="yocS CDS" gene 1910305..1911270 /gene="yocS" /locus_tag="BSU_19350" /old_locus_tag="BSU19350" /label="yocS gene" downshifts 1911258 /Source="Nicolas_upshifts" /id="D1067" /incds=0 /nref=42 /ntot=166 /MaxReadThrough="3.53218" /MaxDrop="5.09676" /score="30.279305" /energy="-16.4" /TU="U1581" /idTUdmin="U1581" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(1911320..1912573) /gene="odhB" /locus_tag="BSU_19360" /old_locus_tag="BSU19360" /EC_number="2.3.1.61" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1508153, 2500417, 22720735, 26098117" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1508153, 2500417, 22720735, 26098117; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-oxoglutarate dehydrogenase complex (dihydrolipoamide transsuccinylase, E2 subunit)" /protein_id="NP_389818.2" /db_xref="EnsemblGenomes-Gn:BSU19360" /db_xref="EnsemblGenomes-Tr:CAB13828" /db_xref="GOA:P16263" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR001078" /db_xref="InterPro:IPR003016" /db_xref="InterPro:IPR004167" /db_xref="InterPro:IPR006255" /db_xref="InterPro:IPR011053" /db_xref="InterPro:IPR036625" /db_xref="SubtiList:BG10273" /db_xref="UniProtKB/Swiss-Prot:P16263" /translation="MAEIKVPELAESISEGTIAQWLKQPGDYVEQGEYLLELETDKVN VELTAEESGVLQEVLKDSGDTVQVGEIIGTISEGAGESSAPAPTEKTESKESVKEEKQ AEPAAQEVSEEAQSEAKSRTIASPSARKLAREKGIDLSQVPTGDPLGRVRKQDVEAYE KPASKPAPQQKQQPQAQKAQQSFDKPVEVQKMSRRRQTIAKRLVEVQQTSAMLTTFNE VDMTAVMNLRKRRKDQFFEQNEVKLGFMSFFTKAVVAALKKYPLLNAEIQGDELIVKK FYDIGIAVAADEGLVVPVVRDADRLTFAGIEKEIGELAKKARNNKLTLSELQGGSFTI TNGGTFGSLMSTPILNSPQVGILGMHKIQLRPVAIDEERFENRPMMYIALSYDHRIVD GKEAVGFLVTIKNLLEDPEQLLLEG*" /label="odhB CDS" gene complement(1911320..1912573) /gene="odhB" /locus_tag="BSU_19360" /old_locus_tag="BSU19360" /label="odhB gene" downshifts complement(1911334) /Source="Nicolas_upshifts" /id="D1068" /incds=0 /nref=200 /ntot=253 /MaxReadThrough="5.25481" /MaxDrop="7.42366" /score="11.7726103" /energy="-16.4" /TU="U1582" /idTUdmin="U1582" /TUdmin="-1694" /isTUend="FALSE" /label="downshifts" CDS complement(1912589..1915423) /gene="odhA" /locus_tag="BSU_19370" /old_locus_tag="BSU19370" /EC_number="1.2.4.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1508153, 2500417" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1508153, 2500417; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-oxoglutarate dehydrogenase (E1 subunit)" /protein_id="NP_389819.3" /db_xref="EnsemblGenomes-Gn:BSU19370" /db_xref="EnsemblGenomes-Tr:CAB13829" /db_xref="GOA:P23129" /db_xref="InterPro:IPR001017" /db_xref="InterPro:IPR005475" /db_xref="InterPro:IPR011603" /db_xref="InterPro:IPR023784" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR031717" /db_xref="InterPro:IPR032106" /db_xref="SubtiList:BG10272" /db_xref="UniProtKB/Swiss-Prot:P23129" /translation="MFQNSMKQRMNWEDFYGPNLGYALELYDQYTQDPNSIDPDLKEM FDELGAPPSDIKEASGTKEKGRVTADLIQKIASAVRLAEDIRTYGHLNASVNPLRKDE KKSELFPLSDYGLTEEEIKAIPASVICKDAPKNISNGLEAIQYLRNTYKRTISFEFDH VHDFKEREWLTRKIESGELFQKNSAEKLSAVLERLTEVEGFEQFLHRTFVGQKRFSIE GLDALVPVLDDIIAQSVKSGTTSVNIGMAHRGRLNVLAHVLGKPYEIIFSEFQHAPNK DLVPSEGSIGISYGWTGDVKYHLGANRELQDAETKSARITLANNPSHLEFINPIVEGS TRAAQETRTQSGYPVQDETKSLAILIHGDAAFPGEGIVAETLNLSSLKGYQVGGAIHI IANNMIGFTTESAESRSTKYASDLAKGYEIPIVHVNADDPEACLSAVKFAVEYRKTFN KDFLIDLIGYRRYGHNEMDEPSTTQPMLYDAVRKHPTVKQIFAEKLVKEGVVTEEVVQ NIEKSVTKRIEDAYQKVPSKKEHTACEIELPEPVSNGFPDVDTSIDFDVLRKLNGELI NWPESFNVFGKLKRILERRAKAFDDDRKVEWSLAESLAFASILKDGTPIRLTGQDSER GTFAQRNLVLHDSETGKEFVPLHHLSDCSTSFAVHNSPLSEGSVLGFEYGYNVHSPET LVLWEAQYGDFANAAQVYFDQFISAGRAKWGQKSGLVMLLPHGYEGQGPEHSSGRIER FLQLAAENNWTVANLTSAAQYFHILRRQAKMLLREEIRPLVIMTPKSLLRNPNTVSEV QELSESRFQPVYEQSGLSHDYEKVTRLVLSSGKVSIDISDHFNKLEDGKEWLHIARIE QLYPFPAKGVKELFAKLPNLKEIVWVQEEPQNMGAWGYISPYLTEIAPEGVSVQYIGR RRRSSPAEGDPTVHKKEQERIVSDSLTRKN*" /label="odhA CDS" gene complement(1912589..1915423) /gene="odhA" /locus_tag="BSU_19370" /old_locus_tag="BSU19370" /label="odhA gene" promotor_-10 complement(1915518..1915537) /Source="Nicolas_upshift_promotors" /id="U1582" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.718281718281718" /psig=1 /xcortree=2228 /SigmaFactorBS="tataaaggttttttactattttgtgaacaatcaaGGTAGAAT caaattgcaaacagTGGTAAAATATCGTTGGAAGcgtttttattacataattttggac a" /listShort="odhA, odhB, S746, yocR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1915533) /Source="Nicolas_upshifts" /id="U1582" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.718281718281718" /psig=1 /xcortree=2228 /SigmaFactorBS="tataaaggttttttactattttgtgaacaatcaaGGTAGAAT caaattgcaaacagTGGTAAAATATCGTTGGAAGcgtttttattacataattttggac a" /listShort="odhA, odhB, S746, yocR" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1915535..1915651) /Source="Nicolas_S_feature" /locus_tag="new_2111720_2111836_c" /HighExp="dia15, G150, G135, H2O2, Lbexp, dia0, Oxctl, LBGtran, G180, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S747" promotor_-35 complement(1915552..1915559) /Source="Nicolas_upshift_promotors" /id="U1582" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.718281718281718" /psig=1 /xcortree=2228 /SigmaFactorBS="tataaaggttttttactattttgtgaacaatcaaGGTAGAAT caaattgcaaacagTGGTAAAATATCGTTGGAAGcgtttttattacataattttggac a" /listShort="odhA, odhB, S746, yocR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1915652..1917568) /gene="yojO" /locus_tag="BSU_19380" /old_locus_tag="BSU19380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23087684; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative activator of nitric oxide reductase" /protein_id="NP_389820.2" /db_xref="EnsemblGenomes-Gn:BSU19380" /db_xref="EnsemblGenomes-Tr:CAB13830" /db_xref="InterPro:IPR002035" /db_xref="InterPro:IPR036465" /db_xref="SubtiList:BG13567" /db_xref="UniProtKB/Swiss-Prot:O31849" /translation="MKFIKFNDSTIDSFLFMMLTDLAKTLTKSEAVEVEYGVQSYYNP FEKKIYMSHFWKDRAAEDMEAGLKSDVYLRSVGTRYSSLHEFANFLNDIHRHLTFKSF AKQLFMLLEDIRIEECIKRERPGTKHVFAKRKDMYRKHFSTQLTLNLERSIFTDALFC AIYFKLTAESPLETLPSMREDIDLMRPFIEQQLLRVYEADSTRQVLKIVEDLMDGLEE VLDKDMLNTYFFLPELDYAKAAEQPLFEEEKKAPKLSDDITLPKQSDGDEDIHEEEMP TWHRETEAPSKSFLQFDIEHGAKSDLGKDASREGDDGDQALGSVQGSARQTKRKDYSK LEALESQKDQPNGAGMADGKENKYAFPIYKEPQPATSEEELSYKQQAKTIESYQKRLK QMIQKTLEHKKTLPRTDLHAGRLNNKLLRYFTERNPRLFYKKQEPSSEIDAVFTLLVD CSASMFDKMDETKRGIVLFHEALKSVAVPHQIVGFWEDTNDATEKSQPNYFNTVIPFQ SSLRQDSGPAIMQLEPEEDNRDGYAIRQMTKKMLHRSEAQKFLIVFSDGEPAAFGYEQ NGIVDTSEAVIEARKRGIEVINVFLSNSEIEESQMKTIQDMYGKFSIFVPDVDQLPDV LYPLLKKLLHKSIG*" /label="yojO CDS" gene complement(1915652..1917568) /gene="yojO" /locus_tag="BSU_19380" /old_locus_tag="BSU19380" /label="yojO gene" CDS complement(1917579..1918493) /gene="yojN" /locus_tag="BSU_19390" /old_locus_tag="BSU19390" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15491156, 23087684; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative nitric-oxide reductase associated protein" /protein_id="NP_389821.1" /db_xref="EnsemblGenomes-Gn:BSU19390" /db_xref="EnsemblGenomes-Tr:CAB13831" /db_xref="GOA:O31850" /db_xref="InterPro:IPR001270" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011704" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13566" /db_xref="UniProtKB/Swiss-Prot:O31850" /translation="MNRKGNLSMTTQLQHLTLPEDIQQKLLSYKEQPISPEFQSLIGT SGYEAEDEAILFDAIIALAMGKNVLLKGPTGSGKTKLAETLSSYFHKPMHSVNCSVDL DAEALVGYKTIENQSGQATIEFVSGPVTKAMKEGHFLYIDEINMAKPETLPILNGVLD YRKMMTNPFTGEVIRAKSGFGVIAAINEGYVGTVPLNEALKNRFVIIDVPYIKGELLK QVLMSQSALKDEKLIDRFITLSSDLIVQANNGQVSEEAASIRALIDTCDLAAYIPPRR AIERGIVEKLDDDREKAAVRNIAETLFE*" /label="yojN CDS" gene complement(1917579..1918493) /gene="yojN" /locus_tag="BSU_19390" /old_locus_tag="BSU19390" /label="yojN gene" promotor_-10 complement(1918497..1918516) /Source="Nicolas_upshift_promotors" /id="U1583" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1833 /SigmaFactorBS="taacgagaagcagtaatatcatccaggcccttttgTATTGag catacaggggctttTTTAGTATACTCGTTAATGGaatatgaataggaaagggaatctg t" /listShort="yojN, yojO, S747" /listLong="odhA, odhB, S746" /label="promotor_-10" upshifts complement(1918512) /Source="Nicolas_upshifts" /id="U1583" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1833 /SigmaFactorBS="taacgagaagcagtaatatcatccaggcccttttgTATTGag catacaggggctttTTTAGTATACTCGTTAATGGaatatgaataggaaagggaatctg t" /listShort="yojN, yojO, S747" /listLong="odhA, odhB, S746" /label="upshifts" promotor_-35 complement(1918533..1918537) /Source="Nicolas_upshift_promotors" /id="U1583" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1833 /SigmaFactorBS="taacgagaagcagtaatatcatccaggcccttttgTATTGag catacaggggctttTTTAGTATACTCGTTAATGGaatatgaataggaaagggaatctg t" /listShort="yojN, yojO, S747" /listLong="odhA, odhB, S746" /label="promotor_-35" CDS complement(1918557..1919147) /gene="sodC" /locus_tag="BSU_19400" /old_locus_tag="BSU19400" /EC_number="1.15.1.1" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15897454" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15897454; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="superoxide dismutase (exported lipoprotein)" /protein_id="NP_389822.1" /db_xref="EnsemblGenomes-Gn:BSU19400" /db_xref="EnsemblGenomes-Tr:CAB13832" /db_xref="GOA:O31851" /db_xref="InterPro:IPR001424" /db_xref="InterPro:IPR024134" /db_xref="InterPro:IPR036423" /db_xref="PDB:1S4I" /db_xref="PDB:1U3N" /db_xref="PDB:1XTL" /db_xref="PDB:1XTM" /db_xref="SubtiList:BG13565" /db_xref="UniProtKB/Swiss-Prot:O31851" /translation="MHRLLLLMMLTALGVAGCGQKKPPDPPNRVPEKKVVETSAFGHH VQLVNREGKAVGFIEIKESDDEGLDIHISANSLRPGASLGFHIYEKGSCVRPDFESAG GPFNPLNKEHGFNNPMGHHAGDLPNLEVGADGKVDVIMNAPDTSLKKGSKLNILDEDG SAFIIHEQADDYLTNPSGNSGARIVCGALLGNNEKQ*" /label="sodC CDS" gene complement(1918557..1919147) /gene="sodC" /locus_tag="BSU_19400" /old_locus_tag="BSU19400" /label="sodC gene" CDS complement(1919240..1920484) /gene="cwlS" /locus_tag="BSU_19410" /old_locus_tag="BSU19410" /EC_number="3.5.1.-" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16855244, 22139507" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16855244, 22139507; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptidoglycan hydrolase (cell wall-binding d,l-endopeptidase)" /protein_id="NP_389823.1" /db_xref="EnsemblGenomes-Gn:BSU19410" /db_xref="EnsemblGenomes-Tr:CAB13833" /db_xref="GOA:O31852" /db_xref="InterPro:IPR000064" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG13564" /db_xref="UniProtKB/Swiss-Prot:O31852" /translation="MKKKIVAGLAVSAVVGSSMAAAPAEAKTIKVKSGDSLWKLSRQY DTTISALKSENKLKSTVLYVGQSLKVPESSKKSTTSPSNSSKTSTYTVAYGDSLWMIA KNHKMSVSELKSLNSLSSDLIRPGQKLKIKGTSSSSGSNGSKKNSGSNSSGSSKSTYT VKLGDSLWKIANSLNMTVAELKTLNGLTSDTLYPKQVLKIKGSSSPKNGNSGSKKPSN SNPSKTTTYKVKAGDSLWKIANRLGVTVQSIRDKNNLSSDVLQIGQVLTISGASKSNP SNPTKPTKPKDNSGSNIQIGSKIDRMITEAKKYVGVPYRWGGNTPAGFDCSGFIYYLI NNVSSISRLSTAGYWNVMQKVSQPSVGDFVFFTTYKSGPSHMGIYLGGGDFIHASSSG VDISNLSNSYWKQRYLGARSYF*" /label="cwlS CDS" gene complement(1919240..1920484) /gene="cwlS" /locus_tag="BSU_19410" /old_locus_tag="BSU19410" /label="cwlS gene" downshifts complement(1919242) /Source="Nicolas_upshifts" /id="D1069" /incds=0 /nref=20 /ntot=183 /MaxReadThrough="4.09529" /MaxDrop="3.77828" /score="11.0350171" /energy="-4.7" /TU="U1584,U1585" /idTUdmin="U1585" /TUdmin="-616" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1920547..1920565) /Source="Nicolas_upshift_promotors" /id="U1584" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=3048 /SigmaFactorBS="gatgctgaaaatgctgcgccaaatgtttgaaaaggGTTTAAC TtgctgaaaaattGACGATAAAACAGTTGTGTgccatttttggaaacaaaatactagc t" /listShort="cwlS, sodC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1920560) /Source="Nicolas_upshifts" /id="U1584" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=3048 /SigmaFactorBS="gatgctgaaaatgctgcgccaaatgtttgaaaaggGTTTAAC TtgctgaaaaattGACGATAAAACAGTTGTGTgccatttttggaaacaaaatactagc t" /listShort="cwlS, sodC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1920562..1920782) /Source="Nicolas_S_feature" /locus_tag="new_2116747_2116967_c" /HighExp="S2, Lbstat, T2.30H, M0t90, HiOs, T3.0H, Etha, M40t90, T3.30H, SMMPr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S748" promotor_-35 complement(1920578..1920585) /Source="Nicolas_upshift_promotors" /id="U1584" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=3048 /SigmaFactorBS="gatgctgaaaatgctgcgccaaatgtttgaaaaggGTTTAAC TtgctgaaaaattGACGATAAAACAGTTGTGTgccatttttggaaacaaaatactagc t" /listShort="cwlS, sodC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1920768..1920786) /Source="Nicolas_upshift_promotors" /id="U1585" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=541 /SigmaFactorBS="agaacaggctttttgccatttcataagaatgcagagGAAGGG ATTtgacacgccgaTAGAGAATTGATTAGAAAAatagacaagaaaggaggagaaactg c" /listShort="S748, cwlS, sodC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1920782) /Source="Nicolas_upshifts" /id="U1585" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=541 /SigmaFactorBS="agaacaggctttttgccatttcataagaatgcagagGAAGGG ATTtgacacgccgaTAGAGAATTGATTAGAAAAatagacaagaaaggaggagaaactg c" /listShort="S748, cwlS, sodC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1920798..1920806) /Source="Nicolas_upshift_promotors" /id="U1585" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=541 /SigmaFactorBS="agaacaggctttttgccatttcataagaatgcagagGAAGGG ATTtgacacgccgaTAGAGAATTGATTAGAAAAatagacaagaaaggaggagaaactg c" /listShort="S748, cwlS, sodC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1920866..1922083) /gene="yojK" /locus_tag="BSU_19420" /old_locus_tag="BSU19420" /EC_number="2.4.1.-" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative YDP-glycosyltransferase" /protein_id="NP_389824.2" /db_xref="EnsemblGenomes-Gn:BSU19420" /db_xref="EnsemblGenomes-Tr:CAB13834" /db_xref="GOA:O31853" /db_xref="InterPro:IPR002213" /db_xref="InterPro:IPR006326" /db_xref="SubtiList:BG13563" /db_xref="UniProtKB/Swiss-Prot:O31853" /translation="MANVLMIGFPGEGHINPSIGVMKELKSRGENITYYAVKEYKEKI TALDIEFREYHDFRGDYFGKNATGDEERDFTEMLCAFLKACKDIATHIYEEVKHESYD YVIYDHHLLAGKVIANMLKLPRFSLCTTFAMNEEFAKEMMGAYMKGSLEDSPHYESYQ QLAETLNADFQAEIKKPFDVFLADGDLTIVFTSRGFQPLAEQFGERYVFVGPSITERA GNNDFPFDQIDNENVLFISMGTIFNNQKQFFNQCLEVCKDFDGKVVLSIGKHIKTSEL NDIPENFIVRPYVPQLEILKRASLFVTHGGMNSTSEGLYFETPLVVIPMGGDQFVVAD QVEKVGAGKVIKKEELSESLLKETIQEVMNNRSYAEKAKEIGQSLKAAGGSKKAADSI LEAVKQKTQSANA*" /label="yojK CDS" gene complement(1920866..1922083) /gene="yojK" /locus_tag="BSU_19420" /old_locus_tag="BSU19420" /label="yojK gene" downshifts complement(1920892) /Source="Nicolas_upshifts" /id="D1070" /incds=0 /nref=14 /ntot=145 /MaxReadThrough="1.49168" /MaxDrop="4.07727" /score="9.41396656" /energy="-14.4" /TU="NA" /idTUdmin="U1586" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1922116..1922135) /Source="Nicolas_upshift_promotors" /id="U1586" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.498501498501498" /psig="0.994005994005994" /xcortree=2220 /SigmaFactorBS="atatatgatgaatattaattaagtgaaaTACTTTACctgttt atgcattTATAGTACCGTATAAAATATtacataaattctcaaaggaagggtgctgccg c" /listShort="yojK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1922124) /Source="Nicolas_upshifts" /id="U1586" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.498501498501498" /psig="0.994005994005994" /xcortree=2220 /SigmaFactorBS="atatatgatgaatattaattaagtgaaaTACTTTACctgttt atgcattTATAGTACCGTATAAAATATtacataaattctcaaaggaagggtgctgccg c" /listShort="yojK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1922149..1922156) /Source="Nicolas_upshift_promotors" /id="U1586" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.498501498501498" /psig="0.994005994005994" /xcortree=2220 /SigmaFactorBS="atatatgatgaatattaattaagtgaaaTACTTTACctgttt atgcattTATAGTACCGTATAAAATATtacataaattctcaaaggaagggtgctgccg c" /listShort="yojK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1922319..1922942) /gene="cdaS" /locus_tag="BSU_19430" /old_locus_tag="BSU19430" /EC_number="2.7.7.85" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:21566650, 23192352, 24939848, 27252699, 27790204, 28751888" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21566650, 23192352, 24939848, 27252699, 27790204, 28751888; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="spore diadenylate cyclase" /protein_id="NP_389825.3" /db_xref="EnsemblGenomes-Gn:BSU19430" /db_xref="EnsemblGenomes-Tr:CAB13835" /db_xref="GOA:O31854" /db_xref="InterPro:IPR003390" /db_xref="InterPro:IPR014046" /db_xref="InterPro:IPR019457" /db_xref="InterPro:IPR034693" /db_xref="InterPro:IPR036888" /db_xref="SubtiList:BG13562" /db_xref="UniProtKB/Swiss-Prot:O31854" /translation="MKAMRYEQISENAFKGKIQVYLEQILGDASLILKTLHEKDQCLL CELDDLGHVFQDMQGIASSFYLQSYIEEFTPAFIELAKAIKALSEHKHGALIVIERAD PVERFIQKGTSLHAEISSSLIESIFFPGNPLHDGALLVRENKLVSAANVLPLTTKEVD IHLGTRHRAALGMSGYTDALVLVVSEETGKMSFAKDGVLYPLISPRT*" /label="cdaS CDS" gene complement(1922319..1922942) /gene="cdaS" /locus_tag="BSU_19430" /old_locus_tag="BSU19430" /label="cdaS gene" S_feature complement(1922943..1923093) /Source="Nicolas_S_feature" /locus_tag="new_2119128_2119278_c" /HighExp="S8, S5, S7, S6, Etha, S4, M9-stat, S3, C30, Gly" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S749" promotor_-35 1922969..1922975 /Source="Nicolas_upshift_promotors" /id="U1587" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=898 /SigmaFactorBS="gctcatagcgcatagccttcatctcctgtttaaatttccaac ttttcaCGAATGCttatcttattgatGCACATTCTATTggtaaaggagggatgtaaag a" /listShort="S750, norM" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1922981 /Source="Nicolas_upshifts" /id="U1587" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=898 /SigmaFactorBS="gctcatagcgcatagccttcatctcctgtttaaatttccaac ttttcaCGAATGCttatcttattgatGCACATTCTATTggtaaaggagggatgtaaag a" /listShort="S750, norM" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1922989..1923000 /Source="Nicolas_upshift_promotors" /id="U1587" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=898 /SigmaFactorBS="gctcatagcgcatagccttcatctcctgtttaaatttccaac ttttcaCGAATGCttatcttattgatGCACATTCTATTggtaaaggagggatgtaaag a" /listShort="S750, norM" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 1923007..1923015 /Source="Nicolas_upshift_promotors" /id="U1588" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=539 /SigmaFactorBS="atcttattgatgcacattctattggtaaaGGAGGGATGtaaa gaatggaAATCGAAAGAATCATTCAGtatatttgcacctttttaggcgtgatttcgct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_no_box 1923023..1923123 /Source="Nicolas_upshift_promotors" /id="U1589" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.56043956043956" /psig="0.006993006993007" /xcortree=1480 /SigmaFactorBS="tggaaatcgaaagaatcattcagtatatttgcacctttttag gcgtgatttcgctttcttttatttatgcccaaatgtttagaaaaacgaaaccgacaaa a" /listShort="S750, norM" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-10 1923027..1923045 /Source="Nicolas_upshift_promotors" /id="U1588" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=539 /SigmaFactorBS="atcttattgatgcacattctattggtaaaGGAGGGATGtaaa gaatggaAATCGAAAGAATCATTCAGtatatttgcacctttttaggcgtgatttcgct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1923038 /Source="Nicolas_upshifts" /id="U1588" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=539 /SigmaFactorBS="atcttattgatgcacattctattggtaaaGGAGGGATGtaaa gaatggaAATCGAAAGAATCATTCAGtatatttgcacctttttaggcgtgatttcgct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1923076..1923094) /Source="Nicolas_upshift_promotors" /id="U1590" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=740 /SigmaFactorBS="aaaaagcaatgaacgccgggcctattctttttttgtcGGTTT CGtttttctaaacatttGGGCATAAATAAAAGAAAGcgaaatcacgcctaaaaaggtg c" /listShort="S749, yojJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1923083..1923168 /Source="Nicolas_S_feature" /locus_tag="new_2119268_2119353" /HighExp="S8, S7, S4, S5, S6, BT, S3, T5.0H, S2, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigGF" /TUshortPSig="0.00699, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S750" upshifts 1923083 /Source="Nicolas_upshifts" /id="U1589" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.56043956043956" /psig="0.006993006993007" /xcortree=1480 /SigmaFactorBS="tggaaatcgaaagaatcattcagtatatttgcacctttttag gcgtgatttcgctttcttttatttatgcccaaatgtttagaaaaacgaaaccgacaaa a" /listShort="S750, norM" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1923093) /Source="Nicolas_upshifts" /id="U1590" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=740 /SigmaFactorBS="aaaaagcaatgaacgccgggcctattctttttttgtcGGTTT CGtttttctaaacatttGGGCATAAATAAAAGAAAGcgaaatcacgcctaaaaaggtg c" /listShort="S749, yojJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1923110..1923116) /Source="Nicolas_upshift_promotors" /id="U1590" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=740 /SigmaFactorBS="aaaaagcaatgaacgccgggcctattctttttttgtcGGTTT CGtttttctaaacatttGGGCATAAATAAAAGAAAGcgaaatcacgcctaaaaaggtg c" /listShort="S749, yojJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1923144..1923151 /Source="Nicolas_upshift_promotors" /id="U1591" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.634365634365634" /psig=1 /xcortree=2408 /SigmaFactorBS="cgaaaccgacaaaaaaagaataggcccggcgttcATTGCTTT ttatacataaaaTGTTATAATTTCTCTCGTTAtgaaaaagaaacggagatcaatgtat g" /listShort="norM, rsbRC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1923164..1923183 /Source="Nicolas_upshift_promotors" /id="U1591" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.634365634365634" /psig=1 /xcortree=2408 /SigmaFactorBS="cgaaaccgacaaaaaaagaataggcccggcgttcATTGCTTT ttatacataaaaTGTTATAATTTCTCTCGTTAtgaaaaagaaacggagatcaatgtat g" /listShort="norM, rsbRC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1923170 /Source="Nicolas_upshifts" /id="U1591" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.634365634365634" /psig=1 /xcortree=2408 /SigmaFactorBS="cgaaaccgacaaaaaaagaataggcccggcgttcATTGCTTT ttatacataaaaTGTTATAATTTCTCTCGTTAtgaaaaagaaacggagatcaatgtat g" /listShort="norM, rsbRC" /GFF_Attribute="listLong" /label="upshifts" CDS 1923208..1924566 /gene="mdtK" /locus_tag="BSU_19440" /old_locus_tag="BSU19440" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14766544, 15849754, 15855508, 16850406, 16954325, 17114254; Product type t : transporter" /codon_start=1 /transl_table=11 /product="Na+-driven efflux MatE family protein" /protein_id="NP_389826.1" /db_xref="EnsemblGenomes-Gn:BSU19440" /db_xref="EnsemblGenomes-Tr:CAB13836" /db_xref="GOA:O31855" /db_xref="InterPro:IPR002528" /db_xref="SubtiList:BG13561" /db_xref="UniProtKB/Swiss-Prot:O31855" /translation="MKETQNAREKIKQLLHILIPIFITQAGLSLITFLDTVMSGKVSP ADLAGVAIGSSLWTPVYTGLAGILMAVTPIVAQLLGAEKKQKIPFTVLQAVYVAALLS IAVLVIGYAAVDLILGRLNLDIHVHQIAKHFLGFLSLGIFPLFVYTVLRSFIDSLGKT RVTMMITLSSLPINFVLNYVFIFGKFGMPALGGVGAGLASALTYWCICIISFFIIHKN APFSEYGIFLTMYKFSWKACKNLLKIGLPIGFAVFFETSIFAAVTLLMSHFHTVTIAS HQAAMNFASLLYMLPLSVSMALTIVVGFEAGAARFKDARSYSLIGIMMAIGFSLFTAA CILLFREQIAGMYTSDPDVLRLTQHFLIYALFFQLSDAVAAPIQGALRGYKDVNYTLA AAFVSYWVIGLPVGYMVGTFTSLGAFGYWIGLIAGLAAGAVGLFFRLAKLQKRYSQKQ HI*" /label="mdtK CDS" gene 1923208..1924566 /gene="mdtK" /locus_tag="BSU_19440" /old_locus_tag="BSU19440" /label="mdtK gene" promotor_-10 complement(1923550..1923561) /Source="Nicolas_upshift_promotors" /id="U1592" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=946 /SigmaFactorBS="aaagcctaaaaagtgtttagcaatctgatgcacgTGAATATc aaggttcaatcgGCCAAGAATAAGgtcaactgcagcatatccaatcactaaaacggcg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1923555) /Source="Nicolas_upshifts" /id="U1592" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=946 /SigmaFactorBS="aaagcctaaaaagtgtttagcaatctgatgcacgTGAATATc aaggttcaatcgGCCAAGAATAAGgtcaactgcagcatatccaatcactaaaacggcg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1923575..1923581) /Source="Nicolas_upshift_promotors" /id="U1592" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=946 /SigmaFactorBS="aaagcctaaaaagtgtttagcaatctgatgcacgTGAATATc aaggttcaatcgGCCAAGAATAAGgtcaactgcagcatatccaatcactaaaacggcg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1924582..1925430 /gene="rsbRC" /locus_tag="BSU_19450" /old_locus_tag="BSU19450" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15312768, 15583165, 17158665, 20935101, 22287516, 24599254" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15312768, 15583165, 17158665, 20935101, 22287516, 24599254; Product type f : factor" /codon_start=1 /transl_table=11 /product="co-antagonist of RsbT; component of the anxiosome (stressosome)" /protein_id="NP_389827.1" /db_xref="EnsemblGenomes-Gn:BSU19450" /db_xref="EnsemblGenomes-Tr:CAB13837" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR036513" /db_xref="SubtiList:BG13560" /db_xref="UniProtKB/Swiss-Prot:O31856" /translation="MAKNKKLFEYLSQHAETISSTWYETIEETDPNSIYASTDPVVIH NLKSQNLAFNYKINRIFIDDEDVYLPILKEWAFEVTQDQEHLKTPIHYIIREFVRVRD LYVSYVKEFVHLNQNTVKSEEAEDLYHALIKAFDLVIHIFIEEMYKNTSLQLQAQKDM ITELSAPVIVLFHSVGLLPLIGDIDTVRAKLIMENTLHQCAKKKVTQLYIDLSGVAVI DTMVAHQLFSLIEALRLIGVSSTLSGIRPEIAQTAVQLGLSFEGISLRSTLASAIASD LKLKKV*" /label="rsbRC CDS" gene 1924582..1925430 /gene="rsbRC" /locus_tag="BSU_19450" /old_locus_tag="BSU19450" /label="rsbRC gene" promotor_-10 complement(1924846..1924865) /Source="Nicolas_upshift_promotors" /id="U1593" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1361 /SigmaFactorBS="aattctttcacataagaaacatataaATCTCTCACtctgaca aactccCGAATAATATAGTGGATAGGagtttttaaatgctcttgatcctgtgtgactt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1924853) /Source="Nicolas_upshifts" /id="U1593" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1361 /SigmaFactorBS="aattctttcacataagaaacatataaATCTCTCACtctgaca aactccCGAATAATATAGTGGATAGGagtttttaaatgctcttgatcctgtgtgactt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1924879..1924887) /Source="Nicolas_upshift_promotors" /id="U1593" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1361 /SigmaFactorBS="aattctttcacataagaaacatataaATCTCTCACtctgaca aactccCGAATAATATAGTGGATAGGagtttttaaatgctcttgatcctgtgtgactt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1925393 /Source="Nicolas_upshifts" /id="D1071" /incds=0 /nref=10 /ntot=138 /MaxReadThrough="1.62054" /MaxDrop="3.13267" /score="12.3887642" /energy="-14" /TU="NA" /idTUdmin="U1591" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1925425) /Source="Nicolas_upshifts" /id="D1072" /incds=0 /nref=1 /ntot=13 /MaxReadThrough="1.55562" /MaxDrop="4.60101" /score="23.8391861" /energy="-13.7" /TU="NA" /idTUdmin="U1594" /TUdmin=22 /isTUend="TRUE" /label="downshifts" CDS complement(1925456..1926121) /gene="bshBB" /locus_tag="BSU_19460" /old_locus_tag="BSU19460" /EC_number="3.5.1.-" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15136574, 20308541" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15136574, 20308541; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="malate N-acetylglucosamine deacetylase (second enzyme)" /protein_id="YP_054582.2" /db_xref="EnsemblGenomes-Gn:BSU19460" /db_xref="EnsemblGenomes-Tr:CAB13838" /db_xref="GOA:O31857" /db_xref="InterPro:IPR003737" /db_xref="InterPro:IPR023841" /db_xref="InterPro:IPR024078" /db_xref="SubtiList:BG13559" /db_xref="UniProtKB/Swiss-Prot:O31857" /translation="MKEHVLVILPHPDDESYGVAGLIALNRKKDIPVTYACATLGEMG RNMGDPFFANRETLPLLRKQELINACKEMDINDLRMLGLRDKTLEFEDDEYLADIMEE IIDDVKPSLIVTFYPGHGVHPDHDACGEAVIRALYRKKKEDRPRTICMAITRNREEVL GEADVVLDIKEVADIKMNALRAHRTQTEGMLRELEEKLKNNEPVMATWFEEEIYWTYQ WND*" /label="bshBB CDS" gene complement(1925456..1926121) /gene="bshBB" /locus_tag="BSU_19460" /old_locus_tag="BSU19460" /label="bshBB gene" downshifts complement(1925470) /Source="Nicolas_upshifts" /id="D1073" /incds=0 /nref=189 /ntot=251 /MaxReadThrough="3.68743" /MaxDrop="7.13247" /score="23.8391861" /energy="-13.7" /TU="U1594" /idTUdmin="U1596" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1926140..1926490) /gene="yojF" /locus_tag="BSU_19470" /old_locus_tag="BSU19470" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20308541" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (bacillithiol synthesis operon)" /protein_id="NP_389829.1" /db_xref="EnsemblGenomes-Gn:BSU19470" /db_xref="EnsemblGenomes-Tr:CAB13839" /db_xref="InterPro:IPR014934" /db_xref="InterPro:IPR036492" /db_xref="PDB:1NJH" /db_xref="SubtiList:BG13558" /db_xref="UniProtKB/Swiss-Prot:O31858" /translation="MKAIIKEDVQASLERYADRPVYIHLETTTGSYSAHLNEKNMTVV AYIRNAKVTYHQAKIKGNGPYRVGLKTEEGWIYAEGLTEYTVDEENRLLMAGHLPGGK LAISLQISEKPFTV*" /label="yojF CDS" gene complement(1926140..1926490) /gene="yojF" /locus_tag="BSU_19470" /old_locus_tag="BSU19470" /label="yojF gene" CDS complement(1926487..1926765) /gene="yoyC" /locus_tag="BSU_19479" /old_locus_tag="BSU19479" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20308541, 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097741.1" /db_xref="EnsemblGenomes-Gn:BSU19479" /db_xref="EnsemblGenomes-Tr:CAX52638" /db_xref="UniProtKB/Swiss-Prot:O68260" /translation="MDNDKEIVKAYASLWNNRSLAHDDAEAVAEAIDLELLDKRTHPR LRKPMLEKYFAAIQRIVNSQLEPAVKYQLVKLHTERAEYLKEERGEQS*" /label="yoyC CDS" gene complement(1926487..1926765) /gene="yoyC" /locus_tag="BSU_19479" /old_locus_tag="BSU19479" /label="yoyC gene" promotor_-10 complement(1926792..1926811) /Source="Nicolas_upshift_promotors" /id="U1594" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.512487512487512" /psig="0.94105894105894" /xcortree=2009 /SigmaFactorBS="gtggaaacgggcgtcaaaaagccattgaggcctttgGCTTTT CagctgatgcatataTTATGTATAATCATTTCATGtatgtaagacataaaggagcaag a" /listShort="yoyC, yojF, yojG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1926808) /Source="Nicolas_upshifts" /id="U1594" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.512487512487512" /psig="0.94105894105894" /xcortree=2009 /SigmaFactorBS="gtggaaacgggcgtcaaaaagccattgaggcctttgGCTTTT CagctgatgcatataTTATGTATAATCATTTCATGtatgtaagacataaaggagcaag a" /listShort="yoyC, yojF, yojG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1926826..1926832) /Source="Nicolas_upshift_promotors" /id="U1594" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.512487512487512" /psig="0.94105894105894" /xcortree=2009 /SigmaFactorBS="gtggaaacgggcgtcaaaaagccattgaggcctttgGCTTTT CagctgatgcatataTTATGTATAATCATTTCATGtatgtaagacataaaggagcaag a" /listShort="yoyC, yojF, yojG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1926841..1927737) /gene="yojE" /locus_tag="BSU_19480" /old_locus_tag="BSU19480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22226636, 23944997; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative N-acetylated toxic metabolites" /protein_id="NP_389830.2" /db_xref="EnsemblGenomes-Gn:BSU19480" /db_xref="EnsemblGenomes-Tr:CAB13840" /db_xref="GOA:O31859" /db_xref="InterPro:IPR000620" /db_xref="InterPro:IPR004626" /db_xref="SubtiList:BG13557" /db_xref="UniProtKB/Swiss-Prot:O31859" /translation="MQHAETKKGVIYTAVSFIMWGLFPLYWKLLEQLPALDILAHRII WSFVFMCIVLFFLRQWKIGWQELRSLKKNGGILSLFLASILISINWFVYIWAVNHGFL LEASLGYYINPLVSVLLGILFLKEKLNRLQLVAVSIAAAGVIISAFQYGSIPYVALLL AFSFGLYGLSKKRTSLPSAIGLTLETFMIMPIALGYLLFSGHVQPAGAESGGTWLLLF LAGVFTALPLLLFAEGAKRLPLYQVGILQYIAPTITLLIGLFVYHEPFSSSKAFTFSC IWAALLLFTFSQVKWKRASKSH*" /label="yojE CDS" gene complement(1926841..1927737) /gene="yojE" /locus_tag="BSU_19480" /old_locus_tag="BSU19480" /label="yojE gene" promotor_-35 1927579..1927588 /Source="Nicolas_upshift_promotors" /id="U1595" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1337 /SigmaFactorBS="actcctgccatcctattttccattgccgcaagaaaaaaagTA CGATACACataaaaacaaaagACCATATAATACGATGAGCCaaaatatcaagagccgg c" /listShort="S751, gerT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1927599 /Source="Nicolas_upshifts" /id="U1595" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1337 /SigmaFactorBS="actcctgccatcctattttccattgccgcaagaaaaaaagTA CGATACACataaaaacaaaagACCATATAATACGATGAGCCaaaatatcaagagccgg c" /listShort="S751, gerT" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1927602..1927621 /Source="Nicolas_upshift_promotors" /id="U1595" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1337 /SigmaFactorBS="actcctgccatcctattttccattgccgcaagaaaaaaagTA CGATACACataaaaacaaaagACCATATAATACGATGAGCCaaaatatcaagagccgg c" /listShort="S751, gerT" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1927617..1927835 /Source="Nicolas_S_feature" /locus_tag="new_2123802_2124020" /HighExp="S6, S8, S7, BT, S5, B36, G/S, Pyr, B60, SMMPr" /AntisenseName="yojE" /AntisenseCor="-0.562105310907978" /AntisenseRegPval="-23.1" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S751" promotor_-10 complement(1927761..1927780) /Source="Nicolas_upshift_promotors" /id="U1596" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.93006993006993" /psig=1 /xcortree=2446 /SigmaFactorBS="aaacattgtcttcacatcctttcttcacggacaaaatagtat ATGCCCACcagatctttcaCGTGATATAATATAAGATGCtctaaagaaaggcagggat a" /listShort="yojE, yoyC, yojF, yojG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1927781) /Source="Nicolas_upshifts" /id="U1596" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.93006993006993" /psig=1 /xcortree=2446 /SigmaFactorBS="aaacattgtcttcacatcctttcttcacggacaaaatagtat ATGCCCACcagatctttcaCGTGATATAATATAAGATGCtctaaagaaaggcagggat a" /listShort="yojE, yoyC, yojF, yojG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1927792..1927799) /Source="Nicolas_upshift_promotors" /id="U1596" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.93006993006993" /psig=1 /xcortree=2446 /SigmaFactorBS="aaacattgtcttcacatcctttcttcacggacaaaatagtat ATGCCCACcagatctttcaCGTGATATAATATAAGATGCtctaaagaaaggcagggat a" /listShort="yojE, yoyC, yojF, yojG" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1927836..1928309 /gene="gerT" /locus_tag="BSU_19490" /old_locus_tag="BSU19490" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:17720779" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17720779; Product type s: structure" /codon_start=1 /transl_table=11 /product="component of the spore coat" /protein_id="YP_054583.1" /db_xref="EnsemblGenomes-Gn:BSU19490" /db_xref="EnsemblGenomes-Tr:CAE01457" /db_xref="GOA:Q7WY67" /db_xref="InterPro:IPR008978" /db_xref="SubtiList:BG14190" /db_xref="UniProtKB/Swiss-Prot:Q7WY67" /translation="MFEWNKYFPFHNQFSKEALKKADPKEVETYVNRVMESVFGSDYA AQFPFRDPLPQKEHPAKPDAKPDVKPDIDIFETADHVFVKVPISEEWLEQVRIKHTSH ELWLENLPRADHPKKVNLPCLVKRKGTKAVYKDGLLEVMFQKQQDYNMSEVEIIR*" /label="gerT CDS" gene 1927836..1928309 /gene="gerT" /locus_tag="BSU_19490" /old_locus_tag="BSU19490" /label="gerT gene" downshifts 1928306 /Source="Nicolas_upshifts" /id="D1074" /incds=0 /nref=23 /ntot=53 /MaxReadThrough="-0.0703700000000005" /MaxDrop="9.27889" /score="40.8456275" /energy="-16.6" /TU="NA" /idTUdmin="U1595" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS complement(1928344..1928580) /gene="yojB" /locus_tag="BSU_19510" /old_locus_tag="BSU19510" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389832.1" /db_xref="EnsemblGenomes-Gn:BSU19510" /db_xref="EnsemblGenomes-Tr:CAB13842" /db_xref="GOA:O31861" /db_xref="SubtiList:BG13555" /db_xref="UniProtKB/Swiss-Prot:O31861" /translation="MYPHHSYLRGIPGPAGYPARSPFLFGAPLVGGLLGGFLGSALFN YSRPYAYPPGPYGYGGGPYGFGAGVPYGGYPGFY*" /label="yojB CDS" gene complement(1928344..1928580) /gene="yojB" /locus_tag="BSU_19510" /old_locus_tag="BSU19510" /label="yojB gene" downshifts complement(1928352) /Source="Nicolas_upshifts" /id="D1075" /incds=0 /nref=37 /ntot=68 /MaxReadThrough="2.10188" /MaxDrop="7.8003" /score="35.4403926" /energy="-16.6" /TU="NA" /idTUdmin="U1597" /TUdmin=1 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1928603..1928622) /Source="Nicolas_upshift_promotors" /id="U1597" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1296 /SigmaFactorBS="ggcttgtgatgtaacaatcatagacagtccgtaGCCCAATCG TttttcttccttgcTGAATACTTTACGTATAGGCagacataaaggaggaaaaaatcat g" /listShort="yojB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1928618) /Source="Nicolas_upshifts" /id="U1597" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1296 /SigmaFactorBS="ggcttgtgatgtaacaatcatagacagtccgtaGCCCAATCG TttttcttccttgcTGAATACTTTACGTATAGGCagacataaaggaggaaaaaatcat g" /listShort="yojB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1928636..1928645) /Source="Nicolas_upshift_promotors" /id="U1597" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1296 /SigmaFactorBS="ggcttgtgatgtaacaatcatagacagtccgtaGCCCAATCG TttttcttccttgcTGAATACTTTACGTATAGGCagacataaaggaggaaaaaatcat g" /listShort="yojB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1928665..1929999) /gene="yojA" /locus_tag="BSU_19520" /old_locus_tag="BSU19520" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 3020045, 15849754, 16850406, 17114254; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative H+/anion permease" /protein_id="NP_389833.1" /db_xref="EnsemblGenomes-Gn:BSU19520" /db_xref="EnsemblGenomes-Tr:CAB13843" /db_xref="GOA:O31862" /db_xref="InterPro:IPR003474" /db_xref="SubtiList:BG13554" /db_xref="UniProtKB/Swiss-Prot:O31862" /translation="MPILIVAVGVLILLFLIIKVKLNTFVSLIVVSFLVAIGLGMDIN KIVLSIETGIGGQLGHLALVFGLGAMLGRLVSDAGGGYRIAITLIDKFGRKRIQAAVV VASFIIGIALFFEVGLVLLIPIVYAIAKELKMPFLYLGIPMAAALNVTHGFLPPHPAP TAISVAYGAHIGQVLLFGIIIAVPTTVIAGPLFNKFAMKRFPGAYQKHGNLSGLGPRK EFQLDETPGFAISAVTSLFPVIFMAMATIFSLLLSEHSKGKDIIEFIGTPGTAMLISL LLALYTMGYARKISMQEIGRSISESISQIAMMLLIIGGGGAFKQVLIDGGVGDYVADF FRQTNMSPLFVAWTIAAVLRLCLGSATVAALTTAGMAAPLMEAGSVNPALMVLATGAG SVIACHVNDAGFWMVKEFFGLSMKETFQTWTLLTTVLSVTGLGCVLLAGLVM*" /label="yojA CDS" gene complement(1928665..1929999) /gene="yojA" /locus_tag="BSU_19520" /old_locus_tag="BSU19520" /label="yojA gene" S_feature complement(1930000..1930135) /Source="Nicolas_S_feature" /locus_tag="new_2126185_2126320_c" /HighExp="M0t90, M40t90, Lbtran, S1, dia5, Mt0, T0.0H, BI, Lbstat, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.25781100000000001" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S752" promotor_-10 complement(1930132..1930151) /Source="Nicolas_upshift_promotors" /id="U1598" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=324 /SigmaFactorBS="gtaggtaatcgagacaagctcataaaaacGATTGACAgtcat tgattaggaGATTAGTATGAACATATTAGttgatcaaaagataacaatcatataacca a" /listShort="S752, yojA, yojB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1930142) /Source="Nicolas_upshifts" /id="U1598" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=324 /SigmaFactorBS="gtaggtaatcgagacaagctcataaaaacGATTGACAgtcat tgattaggaGATTAGTATGAACATATTAGttgatcaaaagataacaatcatataacca a" /listShort="S752, yojA, yojB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1930166..1930173) /Source="Nicolas_upshift_promotors" /id="U1598" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=324 /SigmaFactorBS="gtaggtaatcgagacaagctcataaaaacGATTGACAgtcat tgattaggaGATTAGTATGAACATATTAGttgatcaaaagataacaatcatataacca a" /listShort="S752, yojA, yojB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1930231..1930238 /Source="Nicolas_upshift_promotors" /id="U1599" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.638361638361638" /psig="0.996003996003996" /xcortree=2766 /SigmaFactorBS="tacctaccgcctaacccaatgatttattagttataTGTTGAT TaacttttggttataTGTTATGTTTTTTAAAGTTGactgccaatcattatatctctcc a" /listShort="S753, yodA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1930253..1930272 /Source="Nicolas_upshift_promotors" /id="U1599" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.638361638361638" /psig="0.996003996003996" /xcortree=2766 /SigmaFactorBS="tacctaccgcctaacccaatgatttattagttataTGTTGAT TaacttttggttataTGTTATGTTTTTTAAAGTTGactgccaatcattatatctctcc a" /listShort="S753, yodA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1930256 /Source="Nicolas_upshifts" /id="U1599" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.638361638361638" /psig="0.996003996003996" /xcortree=2766 /SigmaFactorBS="tacctaccgcctaacccaatgatttattagttataTGTTGAT TaacttttggttataTGTTATGTTTTTTAAAGTTGactgccaatcattatatctctcc a" /listShort="S753, yodA" /GFF_Attribute="listLong" /label="upshifts" S_feature 1930257..1930363 /Source="Nicolas_S_feature" /locus_tag="new_2126442_2126548" /HighExp="M0t90, M40t90, LoTm, Salt, Cold, BI, HPh, LBGstat, GM 60, GM 45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S753" CDS 1930364..1930753 /gene="yodA" /locus_tag="BSU_19530" /old_locus_tag="BSU19530" /EC_number="5.3.2.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative tautomerase" /protein_id="NP_389834.1" /db_xref="EnsemblGenomes-Gn:BSU19530" /db_xref="EnsemblGenomes-Tr:CAB13844" /db_xref="GOA:O34882" /db_xref="InterPro:IPR004370" /db_xref="InterPro:IPR014347" /db_xref="SubtiList:BG13530" /db_xref="UniProtKB/Swiss-Prot:O34882" /translation="MPLLRFDVIEGRDEKSLQLLLDTAHQAMVEAFGVPERDRYQIVH QHPANELIIQDAGLGFQRTKDMVIISMTSKARTESQKEKLYALLAERLEKKCEISPDD LMVSITENGDADWSFGLGEAQFLNGKL*" /label="yodA CDS" gene 1930364..1930753 /gene="yodA" /locus_tag="BSU_19530" /old_locus_tag="BSU19530" /label="yodA gene" downshifts 1930763 /Source="Nicolas_upshifts" /id="D1076" /incds=0 /nref=1 /ntot=8 /MaxReadThrough="1.20831" /MaxDrop="2.65754" /score="14.4455719" /energy="-13.2" /TU="NA" /idTUdmin="U1599" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1931160..1931498) /gene="arxR" /locus_tag="BSU_19540" /old_locus_tag="BSU19540" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17158660, 18208493, 20652907, 27531959" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17158660, 18208493, 20652907, 27531959; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor" /protein_id="NP_389835.1" /db_xref="EnsemblGenomes-Gn:BSU19540" /db_xref="EnsemblGenomes-Tr:CAB13845" /db_xref="GOA:O34844" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:5HS7" /db_xref="PDB:5HS8" /db_xref="PDB:5HS9" /db_xref="SubtiList:BG13531" /db_xref="UniProtKB/Swiss-Prot:O34844" /translation="MGNTMCPKMESAFSLLGKRWNGLIIHVLMDGPKRFKEITETIPM ISQKMLAERLKELEQNEIVERQVLPETPVKVIYTLTEKGTALQAVFQEMQAWADQFCE PGDTVCEEEK*" /label="arxR CDS" gene complement(1931160..1931498) /gene="arxR" /locus_tag="BSU_19540" /old_locus_tag="BSU19540" /label="arxR gene" promotor_-35 1931521..1931528 /Source="Nicolas_upshift_promotors" /id="U1600" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.674325674325674" /psig=1 /xcortree=2349 /SigmaFactorBS="tttcccataagtcttcatcccttcatctatTGATTGACatgt attcaatgaTCCATTACAATAATCTTTCAagttacatttagtaagcttctaacttttc t" /listShort="S754, yodC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1931542..1931561 /Source="Nicolas_upshift_promotors" /id="U1600" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.674325674325674" /psig=1 /xcortree=2349 /SigmaFactorBS="tttcccataagtcttcatcccttcatctatTGATTGACatgt attcaatgaTCCATTACAATAATCTTTCAagttacatttagtaagcttctaacttttc t" /listShort="S754, yodC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1931551 /Source="Nicolas_upshifts" /id="U1600" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.674325674325674" /psig=1 /xcortree=2349 /SigmaFactorBS="tttcccataagtcttcatcccttcatctatTGATTGACatgt attcaatgaTCCATTACAATAATCTTTCAagttacatttagtaagcttctaacttttc t" /listShort="S754, yodC" /GFF_Attribute="listLong" /label="upshifts" S_feature 1931555..1931627 /Source="Nicolas_S_feature" /locus_tag="new_2127740_2127812" /HighExp="dia5, Diami, dia15, Salt, Lbtran, Heat, HiOs, S1, aero, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S754" promotor_-10 complement(1931586..1931605) /Source="Nicolas_upshift_promotors" /id="U1601" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.882117882117882" /psig="0.997002997002997" /xcortree=3124 /SigmaFactorBS="aaacatccagagtattcgtcatagtgTTTCCTCcttcggata aaCGTGGTATGATAATAGAAAAgttagaagcttactaaatgtaacttgaaagattatt g" /listShort="yodB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1931589) /Source="Nicolas_upshifts" /id="U1601" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.882117882117882" /psig="0.997002997002997" /xcortree=3124 /SigmaFactorBS="aaacatccagagtattcgtcatagtgTTTCCTCcttcggata aaCGTGGTATGATAATAGAAAAgttagaagcttactaaatgtaacttgaaagattatt g" /listShort="yodB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1931617..1931623) /Source="Nicolas_upshift_promotors" /id="U1601" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.882117882117882" /psig="0.997002997002997" /xcortree=3124 /SigmaFactorBS="aaacatccagagtattcgtcatagtgTTTCCTCcttcggata aaCGTGGTATGATAATAGAAAAgttagaagcttactaaatgtaacttgaaagattatt g" /listShort="yodB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1931628..1932236 /gene="noxC" /locus_tag="BSU_19550" /old_locus_tag="BSU19550" /EC_number="1.6.99.3" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 21749987, 24525333, 26312069; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="water forming NADH oxidase (nitroreductase)" /protein_id="NP_389836.1" /db_xref="EnsemblGenomes-Gn:BSU19550" /db_xref="EnsemblGenomes-Tr:CAB13846" /db_xref="GOA:P81102" /db_xref="InterPro:IPR000415" /db_xref="InterPro:IPR029479" /db_xref="SubtiList:BG13532" /db_xref="UniProtKB/Swiss-Prot:P81102" /translation="MTNTLDVLKARASVKEYDTNAPISKEELTELLDLATKAPSAWNL QHWHFTVFHSDESKAELLPVAYNQKQIVESSAVVAILGDLKANENGEEVYAELASQGY ITDEIKQTLLGQINGAYQSEQFARDSAFLNASLAAMQLMIAAKAKGYDTCAIGGFNKE QFQKQFDISERYVPVMLISIGKAVKPAHQSNRLPLSKVSTWL*" /label="noxC CDS" gene 1931628..1932236 /gene="noxC" /locus_tag="BSU_19550" /old_locus_tag="BSU19550" /label="noxC gene" downshifts 1932226 /Source="Nicolas_upshifts" /id="D1077" /incds=0 /nref=98 /ntot=245 /MaxReadThrough="1.58009" /MaxDrop="5.56809" /score="28.8840715" /energy="-14.3" /TU="NA" /idTUdmin="U1600" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" CDS complement(1932279..1932881) /gene="yodD" /locus_tag="BSU_19560" /old_locus_tag="BSU19560" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17407181; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_389837.1" /db_xref="EnsemblGenomes-Gn:BSU19560" /db_xref="EnsemblGenomes-Tr:CAB13847" /db_xref="GOA:O34842" /db_xref="InterPro:IPR002925" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG13533" /db_xref="UniProtKB/Swiss-Prot:O34842" /translation="MKHIYEKGTSDNVLLLLHGTGGNEHDLLSLGRFIDPDAHLLGVR GSVLENGMPRFFKRLSEGVFDEKDLVVRTRELKDFIDEAAETHQFNRGRVIAVGYSNG ANIAASLLFHYKDVLKGAILHHPMVPIRGIELPDMAGLPVFIGAGKYDPLCTKEESEE LYRYLRDSGASASVYWQDGGHQLTQHEAEQAREWYKEAIV*" /label="yodD CDS" gene complement(1932279..1932881) /gene="yodD" /locus_tag="BSU_19560" /old_locus_tag="BSU19560" /label="yodD gene" CDS complement(1932897..1933808) /gene="yodE" /locus_tag="BSU_19570" /old_locus_tag="BSU19570" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106, 17407181, 19329649, 25720121; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thiol-dependent lyase/dioxygenase" /protein_id="NP_389838.1" /db_xref="EnsemblGenomes-Gn:BSU19570" /db_xref="EnsemblGenomes-Tr:CAB13848" /db_xref="GOA:O34543" /db_xref="InterPro:IPR000595" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG13534" /db_xref="UniProtKB/Swiss-Prot:O34543" /translation="MKTEGLHHVTAFARDPQENLRFYTEVLGLRLVKKTVNFDDPGTY HFYFGNQNGDPGTIMTFFPFQGSGQGTVGKGQAGRVYFSVPSGSLSFWKERLEKSGLS LEEKTLFGEKGLIFDDTEDLPLAIMEDAKSGKSEWTPDGITTNEAITGMKGVLLYSYD PQATIQLLTESFGYTKVAEEDQIVRLASSAAVGGVIDVHLHPEKRGVGGYGTVHHVAF RTKKKEQAKWLPIIAENHLPSSEILDREYFTSVYFREKGGILFEIATDEPGFMTDETF AELGTSLKLPEWLEKHRQQITDILPEL*" /label="yodE CDS" gene complement(1932897..1933808) /gene="yodE" /locus_tag="BSU_19570" /old_locus_tag="BSU19570" /label="yodE gene" promotor_-10 complement(1933837..1933856) /Source="Nicolas_upshift_promotors" /id="U1602" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.317682317682318" /psig="0.997002997002997" /xcortree=3021 /SigmaFactorBS="aaatgattttttcaattatttaatcaaaacacatggTTTGCA tccttttcaataaagGTTTAAAATAATAAATATCTtgaaatcgagataaataggagtg a" /listShort="yodE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1933853) /Source="Nicolas_upshifts" /id="U1602" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.317682317682318" /psig="0.997002997002997" /xcortree=3021 /SigmaFactorBS="aaatgattttttcaattatttaatcaaaacacatggTTTGCA tccttttcaataaagGTTTAAAATAATAAATATCTtgaaatcgagataaataggagtg a" /listShort="yodE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1933872..1933877) /Source="Nicolas_upshift_promotors" /id="U1602" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.317682317682318" /psig="0.997002997002997" /xcortree=3021 /SigmaFactorBS="aaatgattttttcaattatttaatcaaaacacatggTTTGCA tccttttcaataaagGTTTAAAATAATAAATATCTtgaaatcgagataaataggagtg a" /listShort="yodE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1933929..1933932 /Source="Nicolas_upshift_promotors" /id="U1603" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2907 /SigmaFactorBS="gattaaataattgaaaaaatcatttttttctaataattatCT TGtgatcttttcttacAACTGCTATTATAGTGAGCAttatcatgtttcaggaggaaag t" /listShort="yoyD, yodF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1933947..1933966 /Source="Nicolas_upshift_promotors" /id="U1603" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2907 /SigmaFactorBS="gattaaataattgaaaaaatcatttttttctaataattatCT TGtgatcttttcttacAACTGCTATTATAGTGAGCAttatcatgtttcaggaggaaag t" /listShort="yoyD, yodF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1933949 /Source="Nicolas_upshifts" /id="U1603" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2907 /SigmaFactorBS="gattaaataattgaaaaaatcatttttttctaataattatCT TGtgatcttttcttacAACTGCTATTATAGTGAGCAttatcatgtttcaggaggaaag t" /listShort="yoyD, yodF" /GFF_Attribute="listLong" /label="upshifts" CDS 1933992..1934192 /gene="yoyD" /locus_tag="BSU_19579" /old_locus_tag="BSU19579" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23504016, 24843172; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="YP_003097742.1" /db_xref="EnsemblGenomes-Gn:BSU19579" /db_xref="EnsemblGenomes-Tr:CAX52639" /db_xref="GOA:C0H431" /db_xref="InterPro:IPR021741" /db_xref="UniProtKB/Swiss-Prot:C0H431" /translation="MVKKALIVILILLPFVQLALLPLVNRIEPIMFGLPFFHFWLLLW IIVTPLCSFGIYQMQKKDGGLE*" /label="yoyD CDS" gene 1933992..1934192 /gene="yoyD" /locus_tag="BSU_19579" /old_locus_tag="BSU19579" /label="yoyD gene" CDS 1934192..1935682 /gene="yodF" /locus_tag="BSU_19580" /old_locus_tag="BSU19580" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12823818, 15849754, 16850406, 24142252, 27766092; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative Na+/metabolite permease" /protein_id="NP_389839.1" /db_xref="EnsemblGenomes-Gn:BSU19580" /db_xref="EnsemblGenomes-Tr:CAB13849" /db_xref="GOA:O34745" /db_xref="InterPro:IPR001734" /db_xref="SubtiList:BG13535" /db_xref="UniProtKB/Swiss-Prot:O34745" /translation="MQGNLTALLITAIIVLTVVCIGFLAGRDKSSRTSVEEWSVGGRR FGGLLVWFLVGADLYTAYTFLGLTSTAFTGGSVAFFAIPYSVLAYFIAYFFLPKLWKV AKIHKLTTLADYARERFNSKLLASLVAIVGVLMLIPYICLQLSGIQDTLQVAGTGYIN VKFVVIISFILVALYTFFSGIKGPTYTAIIKDILVWVIMLFMVVSLPLIHFNGWTPMI DTLVKEAPQMLTIPSEGPKGIPWFITASIVSALALFMWAHAATGVFTAKSADAVRKNS MFLPLYNIVLILVIFLGFIAFLVLPEDTNPRLALLHLIQTSYGGVAQGFAYATIALAS LIPCSIMAIGASNLFANNLYRDLIHPNVSQSKLTLVTRSMVFVVIGLALLFGMLFPTA LVTLQLLGVSGMVQIFPAIAVSLFWKNQTKEATVIGLLAGLAVTFIVYITQSAHGIYE GFWGLAANMIAVVILNPLFVKNAGSNPVIEGLFGKKQDANPNQKGA*" /label="yodF CDS" gene 1934192..1935682 /gene="yodF" /locus_tag="BSU_19580" /old_locus_tag="BSU19580" /label="yodF gene" promotor_-10 complement(1934927..1934938) /Source="Nicolas_upshift_promotors" /id="U1604" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=821 /SigmaFactorBS="ttcgccgtgaaaacacctgtagcggcatgtgccCACATAAaa agtgccagagcGGAAACAATAGAtgctgtgataaaccaaggaatgccttttggccctt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1934931) /Source="Nicolas_upshifts" /id="U1604" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=821 /SigmaFactorBS="ttcgccgtgaaaacacctgtagcggcatgtgccCACATAAaa agtgccagagcGGAAACAATAGAtgctgtgataaaccaaggaatgccttttggccctt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1934952..1934958) /Source="Nicolas_upshift_promotors" /id="U1604" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=821 /SigmaFactorBS="ttcgccgtgaaaacacctgtagcggcatgtgccCACATAAaa agtgccagagcGGAAACAATAGAtgctgtgataaaccaaggaatgccttttggccctt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1935670 /Source="Nicolas_upshifts" /id="D1078" /incds=0 /nref=128 /ntot=189 /MaxReadThrough="1.75716" /MaxDrop="6.37839" /score="42.3111155" /energy="-14.6" /TU="NA" /idTUdmin="U1603" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" CDS complement(1935717..1937117) /gene="ctpA" /locus_tag="BSU_19590" /old_locus_tag="BSU19590" /EC_number="3.4.21.102" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8996100, 10974125, 14526016, 17114254, 19889088; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="carboxy-terminal processing protease (Prc homolog, tail specific protease)" /protein_id="NP_389840.1" /db_xref="EnsemblGenomes-Gn:BSU19590" /db_xref="EnsemblGenomes-Tr:CAB13850" /db_xref="GOA:O34666" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR002477" /db_xref="InterPro:IPR004447" /db_xref="InterPro:IPR005151" /db_xref="InterPro:IPR029045" /db_xref="InterPro:IPR036034" /db_xref="InterPro:IPR036365" /db_xref="InterPro:IPR036366" /db_xref="SubtiList:BG11794" /db_xref="UniProtKB/Swiss-Prot:O34666" /translation="MKRQLKLFFIVLITAVVASALTLFITGNSSILGQKSASTGDSKF DKLNKAYEQIKSDYYQKTDDDKLVDGAIKGMIQSLDDPYSTYMDQEQAKSFDETISAS FEGIGAQVEEKDGEILIVSPIKGSPAEKAGIKPRDQIIKVNGKSVKGMNVNEAVALIR GKKGTKVKLELNRAGVGNIDLSIKRDTIPVETVYSEMKDNNIGEIQITSFSETTAKEL TDAIDSLEKKGAKGYILDLRGNPGGLMEQAITMSNLFIDKGKNIMQVEYKNGSKEVMK AEKERKVTKPTVVLVNDGTASAAEIMAAALHESSNVPLIGETTFGKGTVQTAKEYDDG STVKLTVAKWLTADGEWIHKKGIKPQVKAELPDYAKLPYLDADKTYKSGDTGTNVKVA QKMLKALGYKVKVNSMYDQDFVSVVKQFQKKEKLNETGILTGDTTTKLMIELQKKLSD NDTQMEKAIETLKKEM*" /label="ctpA CDS" gene complement(1935717..1937117) /gene="ctpA" /locus_tag="BSU_19590" /old_locus_tag="BSU19590" /label="ctpA gene" downshifts complement(1935741) /Source="Nicolas_upshifts" /id="D1079" /incds=0 /nref=188 /ntot=292 /MaxReadThrough="0.590400000000001" /MaxDrop="7.62713" /score="34.5981085" /energy="-14.6" /TU="NA" /idTUdmin="U1606" /TUdmin="-18" /isTUend="TRUE" /label="downshifts" promotor_-35 1936888..1936897 /Source="Nicolas_upshift_promotors" /id="U1605" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=383 /SigmaFactorBS="tgtagaatacggatcatccagtgatTGAATCATTCctttaat tgctCCGTCTACTAATTTGTcatcatctgttttttggtaataatcacttttgatttgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1936909..1936924 /Source="Nicolas_upshift_promotors" /id="U1605" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=383 /SigmaFactorBS="tgtagaatacggatcatccagtgatTGAATCATTCctttaat tgctCCGTCTACTAATTTGTcatcatctgttttttggtaataatcacttttgatttgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1936923 /Source="Nicolas_upshifts" /id="U1605" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=383 /SigmaFactorBS="tgtagaatacggatcatccagtgatTGAATCATTCctttaat tgctCCGTCTACTAATTTGTcatcatctgttttttggtaataatcacttttgatttgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1937137..1937156) /Source="Nicolas_upshift_promotors" /id="U1606" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.878121878121878" /psig=1 /xcortree=3142 /SigmaFactorBS="gaaaagcaaaagaagggcgtttctctttcatttctgctccGA GTTGACgaataagaattcgTCCATGATAATAATGTAAGAagaaaaaggtggtgtttaa t" /listShort="ctpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1937157) /Source="Nicolas_upshifts" /id="U1606" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.878121878121878" /psig=1 /xcortree=3142 /SigmaFactorBS="gaaaagcaaaagaagggcgtttctctttcatttctgctccGA GTTGACgaataagaattcgTCCATGATAATAATGTAAGAagaaaaaggtggtgtttaa t" /listShort="ctpA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1937170..1937177) /Source="Nicolas_upshift_promotors" /id="U1606" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.878121878121878" /psig=1 /xcortree=3142 /SigmaFactorBS="gaaaagcaaaagaagggcgtttctctttcatttctgctccGA GTTGACgaataagaattcgTCCATGATAATAATGTAAGAagaaaaaggtggtgtttaa t" /listShort="ctpA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1937216..1937225 /Source="Nicolas_upshift_promotors" /id="U1607" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1327 /SigmaFactorBS="tcaactcggagcagaaatgaaagagaaacgcccttcttttgc tttTCATAAACCTatgtctttatacGACATATGATAAGGAAAAAGgaggattcgatat t" /listShort="yodH, yodI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1937231 /Source="Nicolas_upshifts" /id="U1607" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1327 /SigmaFactorBS="tcaactcggagcagaaatgaaagagaaacgcccttcttttgc tttTCATAAACCTatgtctttatacGACATATGATAAGGAAAAAGgaggattcgatat t" /listShort="yodH, yodI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1937238..1937257 /Source="Nicolas_upshift_promotors" /id="U1607" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1327 /SigmaFactorBS="tcaactcggagcagaaatgaaagagaaacgcccttcttttgc tttTCATAAACCTatgtctttatacGACATATGATAAGGAAAAAGgaggattcgatat t" /listShort="yodH, yodI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1937270..1937971 /gene="yodH" /locus_tag="BSU_19600" /old_locus_tag="BSU19600" /EC_number="2.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19703276; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative S-adenosylmethionine-dependent methyltransferase" /protein_id="NP_389841.1" /db_xref="EnsemblGenomes-Gn:BSU19600" /db_xref="EnsemblGenomes-Tr:CAB13851" /db_xref="GOA:O34954" /db_xref="InterPro:IPR013216" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG13536" /db_xref="UniProtKB/Swiss-Prot:O34954" /translation="MSRYLEMLSLFGVAGAHPGGLAFSKAVLQKAAPSPDQPILDAGC GTGQTAAYLGHLLYPVTVVDKDPIMLEKAKKRFANEGLAIPAYQAELEHLPFSSESFS CVLSESVLSFSRLTSSLQEISRVLKPSGMLIGIEAALKKPMPPAEKKQMMDFYGFTCL HEESEWHKLLRSYGFQKTEAMSLLPEDMEFEPTTEMDLSQTIDPIYYDTLQTHYQLMQ LYSEYMGHCIFIAYK*" /label="yodH CDS" gene 1937270..1937971 /gene="yodH" /locus_tag="BSU_19600" /old_locus_tag="BSU19600" /label="yodH gene" promotor_-35 1937996..1938004 /Source="Nicolas_upshift_promotors" /id="U1608" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1407 /SigmaFactorBS="tacaagtaaaacggcgtatcgccccctgttttcGTCCAACCT ttttttcctatctATCATATGCTGATAGAAAGTcaggataggaggggaacaatattgg a" /listShort="yodI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1938018..1938037 /Source="Nicolas_upshift_promotors" /id="U1608" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1407 /SigmaFactorBS="tacaagtaaaacggcgtatcgccccctgttttcGTCCAACCT ttttttcctatctATCATATGCTGATAGAAAGTcaggataggaggggaacaatattgg a" /listShort="yodI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1938023 /Source="Nicolas_upshifts" /id="U1608" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1407 /SigmaFactorBS="tacaagtaaaacggcgtatcgccccctgttttcGTCCAACCT ttttttcctatctATCATATGCTGATAGAAAGTcaggataggaggggaacaatattgg a" /listShort="yodI" /GFF_Attribute="listLong" /label="upshifts" CDS 1938059..1938310 /gene="yodI" /locus_tag="BSU_19610" /old_locus_tag="BSU19610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12562816, 22882546, 23155385; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_389842.1" /db_xref="EnsemblGenomes-Gn:BSU19610" /db_xref="EnsemblGenomes-Tr:CAB13852" /db_xref="GOA:O34654" /db_xref="SubtiList:BG13537" /db_xref="UniProtKB/Swiss-Prot:O34654" /translation="MERYYHLCKNHQGKVVRITERGGRVHVGRITRVTRDRVFIAPVG GGPRGFGYGYWGGYWGYGAAYGISLGLIAGVALAGLFFW*" /label="yodI CDS" gene 1938059..1938310 /gene="yodI" /locus_tag="BSU_19610" /old_locus_tag="BSU19610" /label="yodI gene" downshifts 1938331 /Source="Nicolas_upshifts" /id="D1080" /incds=0 /nref=49 /ntot=83 /MaxReadThrough="0.88268" /MaxDrop="7.18785" /score="13.9812819" /energy="-15.5" /TU="NA" /idTUdmin="U1607" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1938381..1939202) /gene="ldcB" /locus_tag="BSU_19620" /old_locus_tag="BSU19620" /EC_number="3.4.16.4" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:8631706, 15187182, 24909784" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8631706, 15187182, 24909784; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanyl-D-alanine carboxypeptidase lipoprotein (D-ala releasing from tetrapeptide hydrolysis)" /protein_id="NP_389843.1" /db_xref="EnsemblGenomes-Gn:BSU19620" /db_xref="EnsemblGenomes-Tr:CAB13853" /db_xref="GOA:O34866" /db_xref="InterPro:IPR003709" /db_xref="InterPro:IPR009045" /db_xref="PDB:4OX3" /db_xref="SubtiList:BG13538" /db_xref="UniProtKB/Swiss-Prot:O34866" /translation="MKKSGKWFSLAAALSVTAIVGAGCSMSNGDAQKDTKTTAETKQT EQKTADSKKSNTQNSEFSLESQYFNDIKKVDGLETIQNPENILALVNKQYALPGNYEP SDLVIPDVEFSFEEKIQKRYIRKEAADALKTMFDAAKKEGYELAAVSGYRSYDRQKVI FDNEVSLKGERKAKEAVAYPGESEHQTGLAMDISSRSNGFELNEAFGSTADGKWVQDN AYKYGFIIRYPKNKEDITKYEYEPWHLRYVGKKAAKVIQDNDLTLEEYFEKVKKI*" /label="ldcB CDS" gene complement(1938381..1939202) /gene="ldcB" /locus_tag="BSU_19620" /old_locus_tag="BSU19620" /label="ldcB gene" downshifts complement(1938407) /Source="Nicolas_upshifts" /id="D1081" /incds=0 /nref=180 /ntot=242 /MaxReadThrough="0.784690000000001" /MaxDrop="5.88637" /score="-9.13236272" /energy="-6.1" /TU="NA" /idTUdmin="U1609" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1939203..1939284) /Source="Nicolas_S_feature" /locus_tag="new_2135388_2135469_c" /HighExp="dia15, LBGexp, G180, LBGtran, dia0, H2O2, Oxctl, Lbexp, Paraq, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S755" CDS complement(1939285..1939986) /gene="deoD" /locus_tag="BSU_19630" /old_locus_tag="BSU19630" /EC_number="2.4.2.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12571059, 16511068, 21279421, 21424839" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12571059, 16511068, 21279421, 21424839; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="purine nucleoside phosphorylase" /protein_id="NP_389844.1" /db_xref="EnsemblGenomes-Gn:BSU19630" /db_xref="EnsemblGenomes-Tr:CAB13854" /db_xref="GOA:O34925" /db_xref="InterPro:IPR000845" /db_xref="InterPro:IPR004402" /db_xref="InterPro:IPR018016" /db_xref="InterPro:IPR035994" /db_xref="PDB:4D8V" /db_xref="PDB:4D8X" /db_xref="PDB:4D8Y" /db_xref="PDB:4D98" /db_xref="PDB:4D9H" /db_xref="PDB:4DA0" /db_xref="PDB:4DA6" /db_xref="PDB:4DA7" /db_xref="PDB:4DA8" /db_xref="PDB:4DAB" /db_xref="PDB:4DAE" /db_xref="PDB:4DAN" /db_xref="PDB:4DAO" /db_xref="PDB:4DAR" /db_xref="SubtiList:BG12581" /db_xref="UniProtKB/Swiss-Prot:O34925" /translation="MSVHIGAEKGQIADTVLLPGDPLRAKFIAETYLENVECYNEVRG MYGFTGTYKGKKISVQGTGMGVPSISIYVNELIQSYDVQNLIRVGSCGAIRKDVKVRD VILAMTSSTDSQMNRVAFGSVDFAPCADFELLKNAYDAAKDKGVPVTVGSVFTADQFY NDDSQIEKLAKYGVLGVEMETTALYTLAAKHGRKALSILTVSDHVLTGEETTAEERQT TFHDMIEVALHSVSQ*" /label="deoD CDS" gene complement(1939285..1939986) /gene="deoD" /locus_tag="BSU_19630" /old_locus_tag="BSU19630" /label="deoD gene" S_feature complement(1939987..1940076) /Source="Nicolas_S_feature" /locus_tag="new_2136172_2136261_c" /HighExp="dia15, G180, dia5, LBGtran, dia0, LBGexp, Lbexp, G150, Oxctl, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S756" promotor_-10 complement(1940061..1940080) /Source="Nicolas_upshift_promotors" /id="U1609" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.65034965034965" /psig="0.999000999001" /xcortree=2571 /SigmaFactorBS="ccgtttttctgaggaagtgcctaacagatcctcgaaCATTTc ttttttcgatatatTCCTTTATAATCAATGCTGAagtttgtttcatcatgacattcgt t" /listShort="S756, deoD, S755, yodJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1940076) /Source="Nicolas_upshifts" /id="U1609" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.65034965034965" /psig="0.999000999001" /xcortree=2571 /SigmaFactorBS="ccgtttttctgaggaagtgcctaacagatcctcgaaCATTTc ttttttcgatatatTCCTTTATAATCAATGCTGAagtttgtttcatcatgacattcgt t" /listShort="S756, deoD, S755, yodJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1940096..1940100) /Source="Nicolas_upshift_promotors" /id="U1609" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.65034965034965" /psig="0.999000999001" /xcortree=2571 /SigmaFactorBS="ccgtttttctgaggaagtgcctaacagatcctcgaaCATTTc ttttttcgatatatTCCTTTATAATCAATGCTGAagtttgtttcatcatgacattcgt t" /listShort="S756, deoD, S755, yodJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1940134..1940140 /Source="Nicolas_upshift_promotors" /id="U1610" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=862 /SigmaFactorBS="gttaggcacttcctcagaaaaaCGGATAAtcggggtgttaat tTGAAAACCTAACcgcaggaaggaggggtgggacatgggtaaaaaacatcgtaaccgg a" /listShort="yoyE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1940155..1940166 /Source="Nicolas_upshift_promotors" /id="U1610" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=862 /SigmaFactorBS="gttaggcacttcctcagaaaaaCGGATAAtcggggtgttaat tTGAAAACCTAACcgcaggaaggaggggtgggacatgggtaaaaaacatcgtaaccgg a" /listShort="yoyE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1940172 /Source="Nicolas_upshifts" /id="U1610" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=862 /SigmaFactorBS="gttaggcacttcctcagaaaaaCGGATAAtcggggtgttaat tTGAAAACCTAACcgcaggaaggaggggtgggacatgggtaaaaaacatcgtaaccgg a" /listShort="yoyE" /GFF_Attribute="listLong" /label="upshifts" CDS 1940188..1940313 /gene="yoyE" /locus_tag="BSU_19639" /old_locus_tag="BSU19639" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 24079885" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097743.1" /db_xref="EnsemblGenomes-Gn:BSU19639" /db_xref="EnsemblGenomes-Tr:CAX52640" /db_xref="UniProtKB/Swiss-Prot:C0H432" /translation="MGKKHRNRITGQKKNNHIPEKDIIAAEEAHGKEYSAAKRKP*" /label="yoyE CDS" gene 1940188..1940313 /gene="yoyE" /locus_tag="BSU_19639" /old_locus_tag="BSU19639" /label="yoyE gene" downshifts 1940311 /Source="Nicolas_upshifts" /id="D1082" /incds=0 /nref=9 /ntot=26 /MaxReadThrough="0.67198" /MaxDrop="4.89617" /score="16.4028635" /energy="-8.5" /TU="NA" /idTUdmin="U1610" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1940353..1940667) /gene="yodL" /locus_tag="BSU_19640" /old_locus_tag="BSU19640" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:24079885, 27215790" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 24079885, 27215790; Product type f: factor" /codon_start=1 /transl_table=11 /product="shape determination factor" /protein_id="NP_389845.2" /db_xref="EnsemblGenomes-Gn:BSU19640" /db_xref="EnsemblGenomes-Tr:CAB13855" /db_xref="InterPro:IPR025923" /db_xref="SubtiList:BG13539" /db_xref="UniProtKB/Swiss-Prot:O30472" /translation="MMLSVFKKKSCSYDVTIFQTPRFGEKKGYRAVYRTELNGSDHQD VLKRAFSLFNVFDTVPSDYDARFMATGDVILIDEGRKGKTYYQLLPAGWRKINRLIVQ TT*" /label="yodL CDS" gene complement(1940353..1940667) /gene="yodL" /locus_tag="BSU_19640" /old_locus_tag="BSU19640" /label="yodL gene" downshifts complement(1940365) /Source="Nicolas_upshifts" /id="D1083" /incds=0 /nref=96 /ntot=232 /MaxReadThrough="1.74792" /MaxDrop="5.79235" /score="-0.334745097" /energy="-8.5" /TU="NA" /idTUdmin="U1611" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1940688..1940706) /Source="Nicolas_upshift_promotors" /id="U1611" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=447 /SigmaFactorBS="aaagattaagcggtttcgacaaaaatagagAGAGGAAAAcac agcaaaaACGCCAATATGTTAAAGAAataaaagggaggggatcttgatgatgttatcc g" /listShort="yodL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1940695) /Source="Nicolas_upshifts" /id="U1611" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=447 /SigmaFactorBS="aaagattaagcggtttcgacaaaaatagagAGAGGAAAAcac agcaaaaACGCCAATATGTTAAAGAAataaaagggaggggatcttgatgatgttatcc g" /listShort="yodL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1940717..1940725) /Source="Nicolas_upshift_promotors" /id="U1611" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=447 /SigmaFactorBS="aaagattaagcggtttcgacaaaaatagagAGAGGAAAAcac agcaaaaACGCCAATATGTTAAAGAAataaaagggaggggatcttgatgatgttatcc g" /listShort="yodL" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1940728..1941339) /gene="pgpB" /locus_tag="BSU_19650" /old_locus_tag="BSU19650" /EC_number="3.1.3.27" /EC_number="3.1.3.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 27528508, 28168443" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 27528508, 28168443; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphatidylglycerol phosphate (PGP) phosphatase; undecaprenyl-pyrophosphate phosphatase (promiscuous activity)" /protein_id="NP_389846.1" /db_xref="EnsemblGenomes-Gn:BSU19650" /db_xref="EnsemblGenomes-Tr:CAB13856" /db_xref="GOA:O34349" /db_xref="InterPro:IPR000326" /db_xref="InterPro:IPR036938" /db_xref="PDB:5JKI" /db_xref="SubtiList:BG13540" /db_xref="UniProtKB/Swiss-Prot:O34349" /translation="MYKPVSLFLFFLILAAAIHTNAVQSADEAISKAAVLIRQPWLNE VMTGITHLGASSFLLPLIVIIGAGMFFYRKTWDGLLMLLVFGTDRLLNKVLKEWIERV RPDFAPLVHESSFSFPSGHSMNAACVYPVIAYFLVKHLPFLSKHKKMVYIIAGVIAVL VGISRVYLGVHFVTDVLGGFSLGLLLFFLVKGFDEKIKRFRQK*" /label="pgpB CDS" gene complement(1940728..1941339) /gene="pgpB" /locus_tag="BSU_19650" /old_locus_tag="BSU19650" /label="pgpB gene" CDS complement(1941417..1941593) /gene="yozD" /locus_tag="BSU_19660" /old_locus_tag="BSU19660" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389847.1" /db_xref="EnsemblGenomes-Gn:BSU19660" /db_xref="EnsemblGenomes-Tr:CAB13857" /db_xref="InterPro:IPR025545" /db_xref="SubtiList:BG13751" /db_xref="UniProtKB/Swiss-Prot:O31863" /translation="MKEIDLVIDTEEIAEFFYRELARRGYIPSEDELFEIADITFDYL IEKCMIDEELDEDE*" /label="yozD CDS" gene complement(1941417..1941593) /gene="yozD" /locus_tag="BSU_19660" /old_locus_tag="BSU19660" /label="yozD gene" downshifts complement(1941421) /Source="Nicolas_upshifts" /id="D1084" /incds=0 /nref=35 /ntot=48 /MaxReadThrough="3.33111" /MaxDrop="5.99901" /score="19.8458751" /energy="-11.9" /TU="U1612,U1613" /idTUdmin="U1615" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(1941432) /Source="Nicolas_upshifts" /id="U1612" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.51048951048951" /psig="0.934065934065934" /xcortree=2494 /SigmaFactorBS="tgaaatcgctgatattacCTTTgattatttgatagaaAAATG TATGATAGATGAAGAgctggatgaagatgagtgaggcttaaaaccggagcggtcagct c" /listShort="yodM, yodL" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1941436..1941455) /Source="Nicolas_upshift_promotors" /id="U1612" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.51048951048951" /psig="0.934065934065934" /xcortree=2494 /SigmaFactorBS="tgaaatcgctgatattacCTTTgattatttgatagaaAAATG TATGATAGATGAAGAgctggatgaagatgagtgaggcttaaaaccggagcggtcagct c" /listShort="yodM, yodL" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1941471..1941474) /Source="Nicolas_upshift_promotors" /id="U1612" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.51048951048951" /psig="0.934065934065934" /xcortree=2494 /SigmaFactorBS="tgaaatcgctgatattacCTTTgattatttgatagaaAAATG TATGATAGATGAAGAgctggatgaagatgagtgaggcttaaaaccggagcggtcagct c" /listShort="yodM, yodL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1941607..1941625) /Source="Nicolas_upshift_promotors" /id="U1613" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1118 /SigmaFactorBS="tttttattcaatatatgactgaaagaattgtttagaacaccg GGTATAattcagcctgtttttTCATAAAACATAAAAAAGGaggcggtacggagatgaa a" /listShort="yozD, yodM" /listLong="yodL" /label="promotor_-10" upshifts complement(1941628) /Source="Nicolas_upshifts" /id="U1613" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1118 /SigmaFactorBS="tttttattcaatatatgactgaaagaattgtttagaacaccg GGTATAattcagcctgtttttTCATAAAACATAAAAAAGGaggcggtacggagatgaa a" /listShort="yozD, yodM" /listLong="yodL" /label="upshifts" S_feature complement(1941630..1941851) /Source="Nicolas_S_feature" /locus_tag="new_2137815_2138036_c" /HighExp="S8, S7, S6, BT, B36, Pyr, G/S, H2O2, S5, G135" /AntisenseName="yoyF" /AntisenseCor="0.43167183745996701" /AntisenseRegPval="-12.9" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S757" promotor_-35 complement(1941641..1941646) /Source="Nicolas_upshift_promotors" /id="U1613" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1118 /SigmaFactorBS="tttttattcaatatatgactgaaagaattgtttagaacaccg GGTATAattcagcctgtttttTCATAAAACATAAAAAAGGaggcggtacggagatgaa a" /listShort="yozD, yodM" /listLong="yodL" /label="promotor_-35" promotor_-35 1941651..1941656 /Source="Nicolas_upshift_promotors" /id="U1614" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=997 /SigmaFactorBS="ttatgttttatgaaaaaacaggctgaattatacccggtGTTC TAaacaattctttcagTCATATATTGAATAAAAAAcgagccatgggaggctgacgcta t" /listShort="yoyF, S758" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1941671..1941689 /Source="Nicolas_upshift_promotors" /id="U1614" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=997 /SigmaFactorBS="ttatgttttatgaaaaaacaggctgaattatacccggtGTTC TAaacaattctttcagTCATATATTGAATAAAAAAcgagccatgggaggctgacgcta t" /listShort="yoyF, S758" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1941673 /Source="Nicolas_upshifts" /id="U1614" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=997 /SigmaFactorBS="ttatgttttatgaaaaaacaggctgaattatacccggtGTTC TAaacaattctttcagTCATATATTGAATAAAAAAcgagccatgggaggctgacgcta t" /listShort="yoyF, S758" /GFF_Attribute="listLong" /label="upshifts" CDS 1941712..1941855 /gene="yoyF" /locus_tag="BSU_19669" /old_locus_tag="BSU19669" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097744.1" /db_xref="EnsemblGenomes-Gn:BSU19669" /db_xref="EnsemblGenomes-Tr:CAX52641" /db_xref="GOA:C0H433" /db_xref="UniProtKB/Swiss-Prot:C0H433" /translation="MIAKMMEALDGERFDIIMEKTLKGMTRVMIWGCLPYFLYVLIRM FTN*" /label="yoyF CDS" gene 1941712..1941855 /gene="yoyF" /locus_tag="BSU_19669" /old_locus_tag="BSU19669" /label="yoyF gene" CDS complement(1941852..1942532) /gene="yodN" /locus_tag="BSU_19670" /old_locus_tag="BSU19670" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389848.1" /db_xref="EnsemblGenomes-Gn:BSU19670" /db_xref="EnsemblGenomes-Tr:CAB13858" /db_xref="SubtiList:BG13541" /db_xref="UniProtKB/Swiss-Prot:O34414" /translation="MKQNKPKFQVGDIVVVIMYGTVGTITKVHQIDKHYLYEVNHNEV LYFESSIQLYKDYEGVIVDMEKLDIEYEFLIGDVVYVKDYGKELFRIIGHRTEIWRYL EDGWEDIIYELTRLKDGEWLETEEEDLTLVLRKYEMDQFVHQLLFVHYVGETGHEIGE DIASSALLQFEGGDEDQDTLHILAVSIVDELLDIYNDYKILYEMFQDEEYKDMMMFVL ESLKEHFS*" /label="yodN CDS" gene complement(1941852..1942532) /gene="yodN" /locus_tag="BSU_19670" /old_locus_tag="BSU19670" /label="yodN gene" S_feature 1941856..1942867 /Source="Nicolas_S_feature" /locus_tag="new_2138041_2139052" /HighExp="LoTm, S3, S8, S7, S4, T5.0H, BT, T4.0H, Pyr, S6" /AntisenseName="yodN" /AntisenseCor="0.52628108909126403" /AntisenseRegPval="-19.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S758" promotor_-10 complement(1942559..1942578) /Source="Nicolas_upshift_promotors" /id="U1615" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1356 /SigmaFactorBS="ttggatatttcctttggttttcatGCCCATGCGAattggctt cacccGGCATACGATAGCGTATGAGaaatgttgcggcgagggggagacaccatgaagc a" /listShort="yodN, S757, yozD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1942565) /Source="Nicolas_upshifts" /id="U1615" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1356 /SigmaFactorBS="ttggatatttcctttggttttcatGCCCATGCGAattggctt cacccGGCATACGATAGCGTATGAGaaatgttgcggcgagggggagacaccatgaagc a" /listShort="yodN, S757, yozD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1942592..1942601) /Source="Nicolas_upshift_promotors" /id="U1615" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1356 /SigmaFactorBS="ttggatatttcctttggttttcatGCCCATGCGAattggctt cacccGGCATACGATAGCGTATGAGaaatgttgcggcgagggggagacaccatgaagc a" /listShort="yodN, S757, yozD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1942683..1942907) /gene="yozE" /locus_tag="BSU_19680" /old_locus_tag="BSU19680" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22843344" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389849.1" /db_xref="EnsemblGenomes-Gn:BSU19680" /db_xref="EnsemblGenomes-Tr:CAB13859" /db_xref="InterPro:IPR010673" /db_xref="InterPro:IPR023089" /db_xref="InterPro:IPR036806" /db_xref="PDB:2FJ6" /db_xref="SubtiList:BG13752" /db_xref="UniProtKB/Swiss-Prot:O31864" /translation="MKSFYHYLLKYRHPKPKDSISEFANQAYEDHSFPKTSTDYHEIS SYLELNADYLHTMATFDEAWDQYESEVHGR*" /label="yozE CDS" gene complement(1942683..1942907) /gene="yozE" /locus_tag="BSU_19680" /old_locus_tag="BSU19680" /label="yozE gene" downshifts complement(1942697) /Source="Nicolas_upshifts" /id="D1085" /incds=0 /nref=115 /ntot=243 /MaxReadThrough="1.81033" /MaxDrop="7.07662" /score="34.0666929" /energy="-10.8" /TU="NA" /idTUdmin="U1616" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(1942948..1942967) /Source="Nicolas_upshift_promotors" /id="U1616" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.619380619380619" /psig="0.983016983016983" /xcortree=637 /SigmaFactorBS="aaacgcaactattttgacttctcctgagtcatgtttcagtat tcttttgttgtAATTTTACACTTGAACTGTAtaatagaacaacaaaagacagacatca g" /listShort="yozE" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1942960) /Source="Nicolas_upshifts" /id="U1616" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.619380619380619" /psig="0.983016983016983" /xcortree=637 /SigmaFactorBS="aaacgcaactattttgacttctcctgagtcatgtttcagtat tcttttgttgtAATTTTACACTTGAACTGTAtaatagaacaacaaaagacagacatca g" /listShort="yozE" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1942994..1943272) /gene="yokU" /locus_tag="BSU_19689" /old_locus_tag="BSU19689" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22843344, 24914178" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097745.1" /db_xref="EnsemblGenomes-Gn:BSU19689" /db_xref="EnsemblGenomes-Tr:CAX52642" /db_xref="InterPro:IPR022451" /db_xref="InterPro:IPR022453" /db_xref="UniProtKB/Swiss-Prot:C0H434" /translation="MKTCEWCGELEAVPGRNTVYWELPDGTRAIELTDTPAMVCSSCG MTYQEENTVKEIEDQLLLIQTKKLPESLTYQQLMETERILKRNYFDFS*" /label="yokU CDS" gene complement(1942994..1943272) /gene="yokU" /locus_tag="BSU_19689" /old_locus_tag="BSU19689" /label="yokU gene" CDS complement(1943269..1944684) /gene="kamA" /locus_tag="BSU_19690" /old_locus_tag="BSU19690" /EC_number="5.4.3.2" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10629195, 10839984, 11148055, 17254853, 18307109, 21538109" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10629195, 10839984, 11148055, 17254853, 18307109, 21538109; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="lysine 2,3-aminomutase" /protein_id="NP_389850.1" /db_xref="EnsemblGenomes-Gn:BSU19690" /db_xref="EnsemblGenomes-Tr:CAB13860" /db_xref="GOA:O34676" /db_xref="InterPro:IPR003739" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR022459" /db_xref="InterPro:IPR025895" /db_xref="SubtiList:BG13542" /db_xref="UniProtKB/Swiss-Prot:O34676" /translation="MKNKWYKPKRHWKEIELWKDVPEEKWNDWLWQLTHTVRTLDDLK KVINLTEDEEEGVRISTKTIPLNITPYYASLMDPDNPRCPVRMQSVPLSEEMHKTKYD LEDPLHEDEDSPVPGLTHRYPDRVLFLVTNQCSMYCRYCTRRRFSGQIGMGVPKKQLD AAIAYIRETPEIRDCLISGGDGLLINDQILEYILKELRSIPHLEVIRIGTRAPVVFPQ RITDHLCEILKKYHPVWLNTHFNTSIEMTEESVEACEKLVNAGVPVGNQAVVLAGIND SVPIMKKLMHDLVKIRVRPYYIYQCDLSEGIGHFRAPVSKGLEIIEGLRGHTSGYAVP TFVVDAPGGGGKIALQPNYVLSQSPDKVILRNFEGVITSYPEPENYIPNQADAYFESV FPETADKKEPIGLSAIFADKEVSFTPENVDRIKRREAYIANPEHETLKDRREKRDQLK EKKFLAQQKKQKETECGGDSS*" /label="kamA CDS" gene complement(1943269..1944684) /gene="kamA" /locus_tag="BSU_19690" /old_locus_tag="BSU19690" /label="kamA gene" promotor_-35 1943940..1943943 /Source="Nicolas_upshift_promotors" /id="U1617" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.68031968031968" /psig="0.995004995004995" /xcortree=2431 /SigmaFactorBS="ccgcgttcaccagcttttcacatgcctcaacggattCTTCtg tcatttcgatgctTGTGTTAAAATGGGTGTTCAgccagaccggatgatattttttcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1943959..1943978 /Source="Nicolas_upshift_promotors" /id="U1617" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.68031968031968" /psig="0.995004995004995" /xcortree=2431 /SigmaFactorBS="ccgcgttcaccagcttttcacatgcctcaacggattCTTCtg tcatttcgatgctTGTGTTAAAATGGGTGTTCAgccagaccggatgatattttttcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1943964 /Source="Nicolas_upshifts" /id="U1617" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.68031968031968" /psig="0.995004995004995" /xcortree=2431 /SigmaFactorBS="ccgcgttcaccagcttttcacatgcctcaacggattCTTCtg tcatttcgatgctTGTGTTAAAATGGGTGTTCAgccagaccggatgatattttttcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1944713..1945540) /gene="kamB" /locus_tag="BSU_19700" /old_locus_tag="BSU19700" /EC_number="2.3.1.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:21538109, 24914178" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21538109, 24914178; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="epsilon-amino-beta-lysine acetyl transferase" /protein_id="NP_389851.1" /db_xref="EnsemblGenomes-Gn:BSU19700" /db_xref="EnsemblGenomes-Tr:CAB13861" /db_xref="GOA:O34895" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR022525" /db_xref="InterPro:IPR029025" /db_xref="SubtiList:BG13543" /db_xref="UniProtKB/Swiss-Prot:O34895" /translation="MLKSIKSSGVTAVLDHDGFNKRIRVVRYDGAIEKALPDIVAAAK EENAEKIIVYAKQHDEPILAKQLFAPEGYLKGYYLGHSACVMVRYLSESRRQTDSYTE EQEIIEAIYRTAPRLRNDSTPVFTMRKAETNDMYQLSMLYKKVFRTYPTPVFDPAYIE KTMNANTVYYIMLDHDRLISAASAEINPELGHAEITDCAVLPEYRGHSLTSFLIEALE KEMAGEDIVHVFSLARASSFGMNAVLYHSGYQYGGRLINNCFIAEGLENMNIWCKQL* " /label="kamB CDS" gene complement(1944713..1945540) /gene="kamB" /locus_tag="BSU_19700" /old_locus_tag="BSU19700" /label="kamB gene" CDS complement(1945518..1946828) /gene="yodQ" /locus_tag="BSU_19710" /old_locus_tag="BSU19710" /EC_number="3.5.1.-" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23944997, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative deacetylase" /protein_id="NP_389852.1" /db_xref="EnsemblGenomes-Gn:BSU19710" /db_xref="EnsemblGenomes-Tr:CAB13862" /db_xref="GOA:O34984" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR010182" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR033687" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG12569" /db_xref="UniProtKB/Swiss-Prot:O34984" /translation="MRMQDIERKVIEWLDQHSAKAIRLLKRLIGEKSTLGSEFNAQAV VLEKLRQFHMDIDVWEPSIKQLKQHPYFKSNRSDFHESPNIVAKKTGAGGGRSLILNG HIDVVPEGSVKDWKYEPYQAVEENGKIYGRGSTDMKGGNTALLFALEALHACDVKLKG DVLFQSVVDEECGGAGTLSAIMRGYRADGALIPEPTNMKLFIKQQGSMWFRITVKGLS AHGGTRYEGVSAIEKSMHVITAIQELEKVRNARISDPLYDNIPIPVPVNIGTISGGAW PSSVADRVVIEGRCGIAPHEKPEAVKLELENWLKDLEYHDEWFKRHPVQVEWFGAQWL PNDLPDDHPLISVLQSAYQKMKQTEPIIEASPWGTDGGLLYHAGDTPVIVFGPGETKT AHQANEYIEVEAMIESAKIIALFVMDWCGLHTDGEDADAQVNKE*" /label="yodQ CDS" gene complement(1945518..1946828) /gene="yodQ" /locus_tag="BSU_19710" /old_locus_tag="BSU19710" /label="yodQ gene" CDS complement(1946837..1947490) /gene="yodR" /locus_tag="BSU_19720" /old_locus_tag="BSU19720" /EC_number="2.8.3.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15150230, 21538109, 24914178; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyloate-acetoacetate CoA-transferase" /protein_id="NP_389853.1" /db_xref="EnsemblGenomes-Gn:BSU19720" /db_xref="EnsemblGenomes-Tr:CAB13863" /db_xref="GOA:O34466" /db_xref="InterPro:IPR004165" /db_xref="InterPro:IPR012791" /db_xref="SubtiList:BG13544" /db_xref="UniProtKB/Swiss-Prot:O34466" /translation="MGLGVAEREQIAKRAATEIKQGMIVNLGIGIPSLVPNFLKPDMQ VMFQAENGVLGIGESPEKGEEDAHLCNAAGYPVRAVKGASYFDTTMSFAMIRKGKIDI TILGALQVSQSGDLANWLVPGKKVPGMGGAMELAQKAKKVVVVMSHTDQKGRPKLTER CTLPLTAAGCVDLIITEKAVLEVDSHHFILKELMNGSTIDEVTRLTEAEIKIDMPFS* " /label="yodR CDS" gene complement(1946837..1947490) /gene="yodR" /locus_tag="BSU_19720" /old_locus_tag="BSU19720" /label="yodR gene" CDS complement(1947475..1948164) /gene="yodS" /locus_tag="BSU_19730" /old_locus_tag="BSU19730" /EC_number="2.8.3.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15150230, 21538109, 24914178; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxoacid CoA-transferase" /protein_id="NP_389854.1" /db_xref="EnsemblGenomes-Gn:BSU19730" /db_xref="EnsemblGenomes-Tr:CAB13864" /db_xref="GOA:O34317" /db_xref="InterPro:IPR004163" /db_xref="InterPro:IPR004165" /db_xref="InterPro:IPR012792" /db_xref="SubtiList:BG13545" /db_xref="UniProtKB/Swiss-Prot:O34317" /translation="MAPFQKAISIDTAIADVRDGSVLMFGGFGGVGSPPSLIEAILDS GVTDLTVICNDAGFPDIGIGPLIVNQRVKTLIASHIGSNPVAGKQMTEGTLEVQFSPQ GTLAERIRAGGAGLGGILTDVGIDNQMVCEKKDIVTVAGKRYLIEEALTADFAFINAY IADEFGNLTYDKTARNMNPLMAMAARRTFAEAERIVPMGEISEEMIVTPGVFVEGVVR SEGVKWKWAWE*" /label="yodS CDS" gene complement(1947475..1948164) /gene="yodS" /locus_tag="BSU_19730" /old_locus_tag="BSU19730" /label="yodS gene" CDS complement(1948171..1949505) /gene="yodT" /locus_tag="BSU_19740" /old_locus_tag="BSU19740" /EC_number="2.6.1.48" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10839984, 15150230; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aminovalerate aminotransferase" /protein_id="NP_389855.1" /db_xref="EnsemblGenomes-Gn:BSU19740" /db_xref="EnsemblGenomes-Tr:CAB13865" /db_xref="GOA:O34662" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG13546" /db_xref="UniProtKB/Swiss-Prot:O34662" /translation="MSSYLIKPELSSAYPVVSYAKGSYVYDQTGKKYLDGSSGAVTCN IGHGVRDVTEKLKEQLDQVSFAYRSQFTSEPAEQLAALLAQELPGDVNWSFFVNSGSE AIETAMKIAIQYWQEKKQTQKSIFLSRWSSYHGITLGALSLSGFYERRYRFTHLIERY PAISAPHIYRLNHETEEDFVQTAADELDTMIKRIGSQFIAGFVAEPIIGAAGAAITPP PGYYERLSEVCRTHDVLFIADEVMTGLGRTGRMLATEHWDTVPDIAVLGKGLGAGYAP IAAAVVSDSIIETIKQGSGVIMSGHTYSAHPYSAKAALEVLRYVLKHGLIKQSEKKGA VLKKKLDEAASQSGIIGEVRGKGLLLGIEFVADQKTKKVFPPEQAITQLIVSEAKKRG LIVYPSKAGIDSGEGDAVIIAPPFTISDGEMEELISIFSETVAAVEKNLKKD*" /label="yodT CDS" gene complement(1948171..1949505) /gene="yodT" /locus_tag="BSU_19740" /old_locus_tag="BSU19740" /label="yodT gene" CDS complement(1949486..1949641) /locus_tag="BSU_19745" /old_locus_tag="BSU19745" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_009513966.1" /translation="MLDAEISKEPSLLGRLFLCEKVFAGNVMPPFGHSYNMVKGVLRW EHEQLFD*" /label="conserved hypothetical protein CDS" gene complement(1949486..1949641) /locus_tag="BSU_19745" /old_locus_tag="BSU19745" /label="gene" promotor_-10 complement(1949524..1949542) /Source="Nicolas_upshift_promotors" /id="U1618" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1149 /SigmaFactorBS="aaggctctttttatgtgaaaaagtttttgcggggaacGTCAT GccgccatttggacacTCATACAATATGGTAAAAGgggttttgaggtgggagcatgag c" /listShort="yodT, yodS, yodR, yodQ, yodP, kamA, yokU, yozE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1949540) /Source="Nicolas_upshifts" /id="U1618" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1149 /SigmaFactorBS="aaggctctttttatgtgaaaaagtttttgcggggaacGTCAT GccgccatttggacacTCATACAATATGGTAAAAGgggttttgaggtgggagcatgag c" /listShort="yodT, yodS, yodR, yodQ, yodP, kamA, yokU, yozE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1949558..1949563) /Source="Nicolas_upshift_promotors" /id="U1618" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1149 /SigmaFactorBS="aaggctctttttatgtgaaaaagtttttgcggggaacGTCAT GccgccatttggacacTCATACAATATGGTAAAAGgggttttgaggtgggagcatgag c" /listShort="yodT, yodS, yodR, yodQ, yodP, kamA, yokU, yozE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1949635..1949868) /gene="yoyG" /locus_tag="BSU_19749" /old_locus_tag="BSU19749" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20156992, 21670523; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative toxin of a type I toxin family (sporulation operon)" /protein_id="YP_003097746.2" /db_xref="EnsemblGenomes-Gn:BSU19749" /db_xref="EnsemblGenomes-Tr:CAX52643" /db_xref="GOA:C0H435" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/Swiss-Prot:C0H435" /translation="MSGCILYFIISLHEIGVCTNHLGLGPHKMSYIVIRKDENSMYGY SGYGYGFGCGTNTFVLIVVLFILLIIVGAAFIC*" /label="yoyG CDS" gene complement(1949635..1949868) /gene="yoyG" /locus_tag="BSU_19749" /old_locus_tag="BSU19749" /label="yoyG gene" downshifts complement(1949642) /Source="Nicolas_upshifts" /id="D1086" /incds=0 /nref=96 /ntot=237 /MaxReadThrough="2.70127" /MaxDrop="7.98506" /score="25.3834194" /energy="-16.5" /TU="NA" /idTUdmin="U1620" /TUdmin="-14" /isTUend="TRUE" /label="downshifts" promotor_-35 1949744..1949748 /Source="Nicolas_upshift_promotors" /id="U1619" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=703 /SigmaFactorBS="agccaaatccgtaaccgtacccagagtatccaTACATgctgt tttCATCCTTTCTTATCAcgatatacgacattttatgcgggccaagtcccaaatggtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1949757..1949771 /Source="Nicolas_upshift_promotors" /id="U1619" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=703 /SigmaFactorBS="agccaaatccgtaaccgtacccagagtatccaTACATgctgt tttCATCCTTTCTTATCAcgatatacgacattttatgcgggccaagtcccaaatggtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1949772 /Source="Nicolas_upshifts" /id="U1619" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=703 /SigmaFactorBS="agccaaatccgtaaccgtacccagagtatccaTACATgctgt tttCATCCTTTCTTATCAcgatatacgacattttatgcgggccaagtcccaaatggtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1949773..1949792) /Source="Nicolas_upshift_promotors" /id="U1620" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1350 /SigmaFactorBS="tatttccttacatgaaataggcgtttGCACAAACCAtttggg acttggccCGCATAAAATGTCGTATATCgtgataagaaaggatgaaaacagcatgtat g" /listShort="yoyG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1949782) /Source="Nicolas_upshifts" /id="U1620" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1350 /SigmaFactorBS="tatttccttacatgaaataggcgtttGCACAAACCAtttggg acttggccCGCATAAAATGTCGTATATCgtgataagaaaggatgaaaacagcatgtat g" /listShort="yoyG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1949807..1949816) /Source="Nicolas_upshift_promotors" /id="U1620" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1350 /SigmaFactorBS="tatttccttacatgaaataggcgtttGCACAAACCAtttggg acttggccCGCATAAAATGTCGTATATCgtgataagaaaggatgaaaacagcatgtat g" /listShort="yoyG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1949828..1950607) /gene="cgeE" /locus_tag="BSU_19750" /old_locus_tag="BSU19750" /function="16.5: Explore" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:1729246, 7592393, 10066829, 27260256" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1729246, 7592393, 10066829, 27260256; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="protein involved in maturation of the outermost layer of the spore" /protein_id="NP_389856.1" /db_xref="EnsemblGenomes-Gn:BSU19750" /db_xref="EnsemblGenomes-Tr:CAB13866" /db_xref="GOA:P42093" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11197" /db_xref="UniProtKB/Swiss-Prot:P42093" /translation="MTGHYSKTEHQYILLTSESASFDHYSVYRDPQLPQIFSHNFVQL HDTFPLERLLNFLPSVPKLLDANYLHLKASPQHVFPLGLKQSLVKSGFVVEDELLYDM KLSDWKGQMGHPLTAWGTAKSLSDGSSIMKIYDSIYIGEAIAEQKLKRKYPFYEADII ILVVCYSDQAQKVPIGCGELFIDHQEKTAKIEEVAILDQFQRKGYGSILVKEMLSIAK SLGMEAAYLVAASTDGATQFYEKLTFKKYERVHTVFHYFLT*" /label="cgeE CDS" gene complement(1949828..1950607) /gene="cgeE" /locus_tag="BSU_19750" /old_locus_tag="BSU19750" /label="cgeE gene" CDS complement(1950636..1951916) /gene="cgeD" /locus_tag="BSU_19760" /old_locus_tag="BSU19760" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:1729246, 10066829, 21665972" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1729246, 10066829, 21665972; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase involved in maturation of the outermost layer of the spore" /protein_id="NP_389857.1" /db_xref="EnsemblGenomes-Gn:BSU19760" /db_xref="EnsemblGenomes-Tr:CAB13867" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG11196" /db_xref="UniProtKB/Swiss-Prot:P42092" /translation="MGEKVSIILTSYNKPDYLQKAIESVIQQTHDLWELFIMDDHSNA ETTAVIHKYLHDRRIQYHNSFVHPADRLKTARYATLINSALPFADGDYISYLTDDTVY HPERLSRMVQEFSHKPEAQAVYSKQKVVHVNERGEEISHFYRNANAVLDQAAFQVDHC SVMHRRSLLNLIHHKFGGYWDDDMKHWNHGDAIFWARLNNFTPFLPINEVLDTTYKTP DSFQNAYRFLPADLIDGSFVKGSDQNVYFFDQGVRHPVGEKWGFLYLNRTVAVPDPYL FQYRIGKILNIPNYILVKEADHPAIFYIEAGKKRRIVDQYAFQFYQFQRKDIVTIGKE EMETLPEGPPITWKRSELIKNPPGRRLFFIEREPFLFLNGVFHPISEQVTRKFFLHQK PISASFRNIQQFPIGKPFYPVYDEIIKKLNIATE*" /label="cgeD CDS" gene complement(1950636..1951916) /gene="cgeD" /locus_tag="BSU_19760" /old_locus_tag="BSU19760" /label="cgeD gene" promotor_-10 complement(1951284..1951302) /Source="Nicolas_upshift_promotors" /id="U1621" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2789 /SigmaFactorBS="attggaatcatggcgacgcaattttttgggcgagactCAACA ACTttaccccatttctGCCGATAAATGAAGTATTAgacacaacctataaaaccccaga t" /listShort="cgeE, yoyG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1951300) /Source="Nicolas_upshifts" /id="U1621" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2789 /SigmaFactorBS="attggaatcatggcgacgcaattttttgggcgagactCAACA ACTttaccccatttctGCCGATAAATGAAGTATTAgacacaacctataaaaccccaga t" /listShort="cgeE, yoyG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1951316..1951323) /Source="Nicolas_upshift_promotors" /id="U1621" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2789 /SigmaFactorBS="attggaatcatggcgacgcaattttttgggcgagactCAACA ACTttaccccatttctGCCGATAAATGAAGTATTAgacacaacctataaaaccccaga t" /listShort="cgeE, yoyG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1951884..1951902) /Source="Nicolas_upshift_promotors" /id="U1622" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=955 /SigmaFactorBS="ggagccgtttttatgtttgacggcgggaggcGGTATAgatgg gagagaaagtGTCTATTATTTTAACAAGTtacaacaaacccgattatttgcaaaaagc g" /listShort="cgeD, cgeE, yoyG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1951894) /Source="Nicolas_upshifts" /id="U1622" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=955 /SigmaFactorBS="ggagccgtttttatgtttgacggcgggaggcGGTATAgatgg gagagaaagtGTCTATTATTTTAACAAGTtacaacaaacccgattatttgcaaaaagc g" /listShort="cgeD, cgeE, yoyG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1951918..1951923) /Source="Nicolas_upshift_promotors" /id="U1622" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=955 /SigmaFactorBS="ggagccgtttttatgtttgacggcgggaggcGGTATAgatgg gagagaaagtGTCTATTATTTTAACAAGTtacaacaaacccgattatttgcaaaaagc g" /listShort="cgeD, cgeE, yoyG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1951981..1952286) /gene="cgeC" /locus_tag="BSU_19770" /old_locus_tag="BSU19770" /function="16.5: Explore" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:1729246, 10066829, 21665972" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1729246, 10066829, 21665972; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="protein involved in maturation of the outermost layer of the spore" /protein_id="NP_389858.1" /db_xref="EnsemblGenomes-Gn:BSU19770" /db_xref="EnsemblGenomes-Tr:CAB13868" /db_xref="SubtiList:BG11195" /db_xref="UniProtKB/Swiss-Prot:P42091" /translation="MDLEKQVDREENQDDLHFILLLLILLIRQSSSEGNPSDLRRQLV FAKELGVPVSKVNLINGDTLQNVIVKEVLTDLVIFQNPLNNTRSHVSLSSVVSWGAF* " /label="cgeC CDS" gene complement(1951981..1952286) /gene="cgeC" /locus_tag="BSU_19770" /old_locus_tag="BSU19770" /label="cgeC gene" downshifts complement(1952114) /Source="Nicolas_upshifts" /id="D1087" /incds=1 /nref=2 /ntot=28 /MaxReadThrough="5.32389" /MaxDrop="2.61092" /score="23.1569137" /energy="-13.4" /TU="U1623" /idTUdmin="U1623" /TUdmin="-2310" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1952310..1952329) /Source="Nicolas_upshift_promotors" /id="U1623" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1417 /SigmaFactorBS="ggaaaatgctgattttttaatggagtggacataGCCTATACC AtaaatcgaagtcgCACATATTGTGAAACAGAGAtaaggataagggagagggatgatt t" /listShort="cgeC, cgeD, cgeE" /listLong="yoyG" /label="promotor_-10" upshifts complement(1952325) /Source="Nicolas_upshifts" /id="U1623" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1417 /SigmaFactorBS="ggaaaatgctgattttttaatggagtggacataGCCTATACC AtaaatcgaagtcgCACATATTGTGAAACAGAGAtaaggataagggagagggatgatt t" /listShort="cgeC, cgeD, cgeE" /listLong="yoyG" /label="upshifts" promotor_-35 complement(1952343..1952352) /Source="Nicolas_upshift_promotors" /id="U1623" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1417 /SigmaFactorBS="ggaaaatgctgattttttaatggagtggacataGCCTATACC AtaaatcgaagtcgCACATATTGTGAAACAGAGAtaaggataagggagagggatgatt t" /listShort="cgeC, cgeD, cgeE" /listLong="yoyG" /label="promotor_-35" promotor_-35 1952422..1952431 /Source="Nicolas_upshift_promotors" /id="U1624" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1410 /SigmaFactorBS="cttaaatagatgaaaaatagatcaggtacggcgttcgACTCA TACCAaataacagccggaAGAATATGAATAACGTGAGTtcactatcgaataggaggtg t" /listShort="cgeA, cgeB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1952445..1952464 /Source="Nicolas_upshift_promotors" /id="U1624" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1410 /SigmaFactorBS="cttaaatagatgaaaaatagatcaggtacggcgttcgACTCA TACCAaataacagccggaAGAATATGAATAACGTGAGTtcactatcgaataggaggtg t" /listShort="cgeA, cgeB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1952445 /Source="Nicolas_upshifts" /id="U1624" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1410 /SigmaFactorBS="cttaaatagatgaaaaatagatcaggtacggcgttcgACTCA TACCAaataacagccggaAGAATATGAATAACGTGAGTtcactatcgaataggaggtg t" /listShort="cgeA, cgeB" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1952466) /Source="Nicolas_upshifts" /id="U1625" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=1242 /SigmaFactorBS="taaatccttttttaactgtgcattttcagagCTCATtacaca caCCTCCTATTCGATAGtgaactcacgttattcatattcttccggctgttatttggta t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1952468..1952482) /Source="Nicolas_upshift_promotors" /id="U1625" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=1242 /SigmaFactorBS="taaatccttttttaactgtgcattttcagagCTCATtacaca caCCTCCTATTCGATAGtgaactcacgttattcatattcttccggctgttatttggta t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1952491..1952495) /Source="Nicolas_upshift_promotors" /id="U1625" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=1242 /SigmaFactorBS="taaatccttttttaactgtgcattttcagagCTCATtacaca caCCTCCTATTCGATAGtgaactcacgttattcatattcttccggctgttatttggta t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1952491..1952892 /gene="cgeA" /locus_tag="BSU_19780" /old_locus_tag="BSU19780" /function="16.5: Explore" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:759239, 14702409, 15621419, 19933362, 21665972" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 759239, 14702409, 15621419, 19933362, 21665972; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore outermost layer component" /protein_id="NP_389859.1" /db_xref="EnsemblGenomes-Gn:BSU19780" /db_xref="EnsemblGenomes-Tr:CAB13869" /db_xref="SubtiList:BG11193" /db_xref="UniProtKB/Swiss-Prot:P42089" /translation="MSSENAQLKKDLIKAVLSPLFPTATEGGENMDSNLKALLDAAID QKVDESETVTAESILDPSLPARWIFARITPGTTISIVTDSGDMIGPVVFVAFDQVHGI VFVTQESSVTPAGQATTLIDVDKVESVTFFS*" /label="cgeA CDS" gene 1952491..1952892 /gene="cgeA" /locus_tag="BSU_19780" /old_locus_tag="BSU19780" /label="cgeA gene" CDS 1952899..1953852 /gene="cgeB" /locus_tag="BSU_19790" /old_locus_tag="BSU19790" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1729246, 10066829, 21665972" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1729246, 10066829, 21665972; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="protein involved in maturation of the outermost layer of the spore" /protein_id="NP_389860.2" /db_xref="EnsemblGenomes-Gn:BSU19790" /db_xref="EnsemblGenomes-Tr:CAB13870" /db_xref="InterPro:IPR024542" /db_xref="SubtiList:BG11194" /db_xref="UniProtKB/Swiss-Prot:P42090" /translation="MKVLYIQSGYGGIYSYFDRWAEECFQNTHTEYMIADKPEAESLM KIEAFQPDFTLMMVGDRVPHDWLTWLKGKDIPVYVWLTEDPFYMDISLQVIKLADAIL TIEQNAALYYQELGYQNVYYVPIPVNHRLFKKMGTEHSYHSNLLIIGYPYPNRVQLMK EAVHLPFTVRVIGKEWGKYLPKKVLKQPHIDVVSTWVPPEQAVHYYNGADIVINAHRP YHFAFNQNTMRIKNASFNNRTFDIAACEAFQLTDLPAAHPFSSIISYHGMNDFKEKAA FYINHPEERQKAAAANYKETVPAFTFDELPAKLKAIHLALS*" /label="cgeB CDS" gene 1952899..1953852 /gene="cgeB" /locus_tag="BSU_19790" /old_locus_tag="BSU19790" /label="cgeB gene" downshifts 1953842 /Source="Nicolas_upshifts" /id="D1088" /incds=0 /nref=4 /ntot=33 /MaxReadThrough="2.94229" /MaxDrop="5.87549" /score="22.1420541" /energy="-9" /TU="NA" /idTUdmin="U1624" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1953923..1955071) /gene="phyC" /locus_tag="BSU_19800" /old_locus_tag="BSU19800" /EC_number="3.1.3.8" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10679209, 12101298, 12111145, 12556126, 16980498, 17269748, 21463636" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10679209, 12101298, 12111145, 12556126, 16980498, 17269748, 21463636; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phytase" /protein_id="NP_389861.1" /db_xref="EnsemblGenomes-Gn:BSU19800" /db_xref="EnsemblGenomes-Tr:CAB13871" /db_xref="GOA:P42094" /db_xref="InterPro:IPR003431" /db_xref="InterPro:IPR011042" /db_xref="SubtiList:BG11198" /db_xref="UniProtKB/Swiss-Prot:P42094" /translation="MKVPKTMLLSTAAGLLLSLTATSVSAHYVNEEHHFKVTAHTETD PVASGDDAADDPAIWVHEKHPEKSKLITTNKKSGLVVYDLDGKQLHSYEFGKLNNVDL RYDFPLNGEKIDIAAASNRSEGKNTIEVYAIDGDKGKLKSITDPNHPISTNISEVYGF SLYHSQKTGAFYALVTGKQGEFEQYEIVDGGKGYVTGKKVREFKLNSQTEGLVADDEY GNLYIAEEDEAIWKFNAEPGGGSKGQVVDRATGDHLTADIEGLTIYYAPNGKGYLMAS SQGNNSYAMYERQGKNRYVANFEITDGEKIDGTSDTDGIDVLGFGLGPKYPYGIFVAQ DGENIDNGQAVNQNFKIVSWEQIAQHLGEMPDLHKQVNPRKLKDRSDG*" /label="phyC CDS" gene complement(1953923..1955071) /gene="phyC" /locus_tag="BSU_19800" /old_locus_tag="BSU19800" /label="phyC gene" downshifts complement(1953940) /Source="Nicolas_upshifts" /id="D1089" /incds=0 /nref=16 /ntot=104 /MaxReadThrough="2.64059" /MaxDrop="5.59857" /score="17.7154517" /energy="-8.7" /TU="NA" /idTUdmin="U1629" /TUdmin=2024 /isTUend="FALSE" /label="downshifts" promotor_-35 1955084..1955088 /Source="Nicolas_upshift_promotors" /id="U1627" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.642357642357642" /psig="0.988011988011988" /xcortree=1704 /SigmaFactorBS="tgtttttggaaccttcatttggtaccctccTCTTTtatcact aacactacTATTGTAAAATATATACAGGtgattaccgtgaggaaaatgaacctttttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1955097..1955116) /Source="Nicolas_upshift_promotors" /id="U1626" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.619380619380619" /psig="0.994005994005994" /xcortree=564 /SigmaFactorBS="cagaaaccctataaaaaaaggttcattttcctcacggtaatc acctgtatATATTTTACAATAGTAGTGTtagtgataaaagaggagggtaccaaatgaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 1955104..1955123 /Source="Nicolas_upshift_promotors" /id="U1627" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.642357642357642" /psig="0.988011988011988" /xcortree=1704 /SigmaFactorBS="tgtttttggaaccttcatttggtaccctccTCTTTtatcact aacactacTATTGTAAAATATATACAGGtgattaccgtgaggaaaatgaacctttttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1955106) /Source="Nicolas_upshifts" /id="U1626" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.619380619380619" /psig="0.994005994005994" /xcortree=564 /SigmaFactorBS="cagaaaccctataaaaaaaggttcattttcctcacggtaatc acctgtatATATTTTACAATAGTAGTGTtagtgataaaagaggagggtaccaaatgaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts 1955114 /Source="Nicolas_upshifts" /id="U1627" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.642357642357642" /psig="0.988011988011988" /xcortree=1704 /SigmaFactorBS="tgtttttggaaccttcatttggtaccctccTCTTTtatcact aacactacTATTGTAAAATATATACAGGtgattaccgtgaggaaaatgaacctttttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1955375..1955383 /Source="Nicolas_upshift_promotors" /id="U1628" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.867132867132867" /psig="0.867132867132867" /xcortree=1422 /SigmaFactorBS="atcattcccctaaattttgttttattggttgctttCATTAAT TCgattacaaagttgAACATATGATGCATGGTAGAgaaacgagagttggaggataagc c" /listShort="ypqP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1955397..1955416 /Source="Nicolas_upshift_promotors" /id="U1628" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.867132867132867" /psig="0.867132867132867" /xcortree=1422 /SigmaFactorBS="atcattcccctaaattttgttttattggttgctttCATTAAT TCgattacaaagttgAACATATGATGCATGGTAGAgaaacgagagttggaggataagc c" /listShort="ypqP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1955400 /Source="Nicolas_upshifts" /id="U1628" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.867132867132867" /psig="0.867132867132867" /xcortree=1422 /SigmaFactorBS="atcattcccctaaattttgttttattggttgctttCATTAAT TCgattacaaagttgAACATATGATGCATGGTAGAgaaacgagagttggaggataagc c" /listShort="ypqP" /GFF_Attribute="listLong" /label="upshifts" CDS 1955441..1956466 /NCBI_locus_tag="A8O17_RS10335" /NCBI_old_locus_tag="A8O17_10335" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_014664318.1" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /codon_start=1 /transl_table=11 /product="polysaccharide biosynthesis protein" /protein_id="WP_003230816.1" /locus_tag="Delta6_BSU_19810-BSU_21670" /modified_by="User" /translation="MPKQQTAELKPFFHNKTVLVTGGTGSIGSQIVKRLLMLTPKQVI VFSKDDSKQYVMSQKYAEDKRLLFVLGDVRDHRRVNQVMKGVDIVFHAAALKQVPTCE DHPFEAIQTNLIGGQNVVEAALSHRVQHVINISTDKAVSPVNTMGATKLLSEKLFHQA NRHVQNKGTLFCSVRFGNVLGSRGSVIPILFEQMMEGEPLTITDKNMTRFFMSIDDAA TLTLQSAAITKGGETFIFKMESLKLEELIHGFEEYASQHGLPRPAAVEVGKRPGEKLH EELTSPHEIESLYEWGNLYAILPEPEKHPDFRKVNLPGYQSDQAPLITKERIAQIIEE LHQEKKA*" /label="Delta6_BSU_19810-BSU_21670" gene 1955441..1956466 /NCBI_locus_tag="A8O17_RS10335" /NCBI_old_locus_tag="A8O17_10335" /locus_tag="Delta6_BSU_19810-BSU_21670" /modified_by="User" /label="Delta6_BSU_19810-BSU_21670" downshifts 1955844 /Source="Nicolas_upshifts" /id="D1090" /incds=0 /nref=18 /ntot=39 /MaxReadThrough="0.75679" /MaxDrop="7.79081" /score="-6.65536786" /energy="-8.7" /TU="NA" /idTUdmin="U1628" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 <1955846..1955850 /Source="Nicolas_upshift_promotors" /id="U1702" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1418 /SigmaFactorBS="tttcatttttgacctcacagccactaATAGTTTCCActaaga aaagtagTAAGTATCTTAAAAAACAGAtaaagctgtatctcctgtgaacacaatgggt g" /listShort="ypqP" /GFF_Attribute="listLong" /label="promotor_-10" SCAR 1955860..1955861 /created_by="User" /note="deletion occured in betwen marked nucleotides" /modified_by="User" /label="Delta_SP_beta" downshifts 1956458 /Source="Nicolas_upshifts" /id="D1134" /incds=0 /nref=22 /ntot=177 /MaxReadThrough="2.90949" /MaxDrop="5.54327" /score="-2.31796312" /energy="-13.5" /TU="NA" /idTUdmin="U1701" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1956510..1956941) /gene="msrB" /locus_tag="BSU_21680" /old_locus_tag="BSU21680" /EC_number="1.8.4.12" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15680230, 16803968, 17031545, 18239417, 18662407; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptide methionine R-sulfoxide reductase" /protein_id="NP_390051.1" /db_xref="EnsemblGenomes-Gn:BSU21680" /db_xref="EnsemblGenomes-Tr:CAB14086" /db_xref="GOA:P54155" /db_xref="InterPro:IPR002579" /db_xref="InterPro:IPR011057" /db_xref="InterPro:IPR028427" /db_xref="PDB:2KZN" /db_xref="PDB:3E0O" /db_xref="SubtiList:BG11628" /db_xref="UniProtKB/Swiss-Prot:P54155" /translation="MAYNKEEKIKSLNRMQYEVTQNNGTEPPFQNEYWDHKEEGLYVD IVSGKPLFTSKDKFDSQCGWPSFTKPIEEEVEEKLDTSHGMIRTEVRSRTADSHLGHV FNDGPGPNGLRYCINSAALRFVPKHKLKEEGYESYLHLFNK*" /label="msrB CDS" gene complement(1956510..1956941) /gene="msrB" /locus_tag="BSU_21680" /old_locus_tag="BSU21680" /label="msrB gene" downshifts complement(1956515) /Source="Nicolas_upshifts" /id="D1135" /incds=0 /nref=229 /ntot=262 /MaxReadThrough="2.46559" /MaxDrop="6.77483" /score="1.42817565" /energy="-12.3" /TU="NA" /idTUdmin="U1704" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS complement(1956942..1957475) /gene="msrA" /locus_tag="BSU_21690" /old_locus_tag="BSU21690" /EC_number="1.8.4.11" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9573155, 16803968, 17062561, 18662407" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9573155, 16803968, 17062561, 18662407; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptide methionine S-sulfoxide reductase" /protein_id="NP_390052.1" /db_xref="EnsemblGenomes-Gn:BSU21690" /db_xref="EnsemblGenomes-Tr:CAB14087" /db_xref="GOA:P54154" /db_xref="InterPro:IPR002569" /db_xref="InterPro:IPR036509" /db_xref="SubtiList:BG11627" /db_xref="UniProtKB/Swiss-Prot:P54154" /translation="MSEKKEIATFAGGCFWCMVKPFDEQPGIEKVVSGYTGGHTENPT YEEVCSETTGHREAVQITFHPDVFPYEKLLELFWQQIDPTDAGGQFADRGSSYRAAIF YHNDKQKELAEASKQRLAESGIFKDPIVTDILKAEPFYEAEGYHQHFYKKNPAHYQRY RTGSGRAGFISEHWGAK*" /label="msrA CDS" gene complement(1956942..1957475) /gene="msrA" /locus_tag="BSU_21690" /old_locus_tag="BSU21690" /label="msrA gene" promotor_-35 1957479..1957485 /Source="Nicolas_upshift_promotors" /id="U1703" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.648351648351648" /psig="0.946053946053946" /xcortree=3087 /SigmaFactorBS="agcctcctgcaaatgtggcgatttcttttttttcagacatac tGGTGCCTcctttgttaataCGTGGTATTATTATATTATAgcatgtaaaaatagaatg a" /listShort="S817, ypoP, S818" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1957496..1957606 /Source="Nicolas_S_feature" /locus_tag="new_2288083_2288193" /HighExp="B60, Lbstat, Cold, M9-stat, T4.0H, LoTm, S0, T3.30H, BC, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.946" /TUlongSig="NA" /TUlongPSig="NA" /label="S817" upshifts 1957496 /Source="Nicolas_upshifts" /id="U1703" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.648351648351648" /psig="0.946053946053946" /xcortree=3087 /SigmaFactorBS="agcctcctgcaaatgtggcgatttcttttttttcagacatac tGGTGCCTcctttgttaataCGTGGTATTATTATATTATAgcatgtaaaaatagaatg a" /listShort="S817, ypoP, S818" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1957498..1957517 /Source="Nicolas_upshift_promotors" /id="U1703" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.648351648351648" /psig="0.946053946053946" /xcortree=3087 /SigmaFactorBS="agcctcctgcaaatgtggcgatttcttttttttcagacatac tGGTGCCTcctttgttaataCGTGGTATTATTATATTATAgcatgtaaaaatagaatg a" /listShort="S817, ypoP, S818" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1957503..1957522) /Source="Nicolas_upshift_promotors" /id="U1704" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig=1 /xcortree=2072 /SigmaFactorBS="gcatattgcttaaaacctatagattttattgaaaagcagaat caTTttcattctatttttaCATGCTATAATATAATAATAccacgtattaacaaaggag g" /listShort="msrA, msrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1957523) /Source="Nicolas_upshifts" /id="U1704" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig=1 /xcortree=2072 /SigmaFactorBS="gcatattgcttaaaacctatagattttattgaaaagcagaat caTTttcattctatttttaCATGCTATAATATAATAATAccacgtattaacaaaggag g" /listShort="msrA, msrB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1957538..1957539) /Source="Nicolas_upshift_promotors" /id="U1704" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig=1 /xcortree=2072 /SigmaFactorBS="gcatattgcttaaaacctatagattttattgaaaagcagaat caTTttcattctatttttaCATGCTATAATATAATAATAccacgtattaacaaaggag g" /listShort="msrA, msrB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1957607..1958032 /gene="ypoP" /locus_tag="BSU_21700" /old_locus_tag="BSU21700" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9571784, 10809700; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)" /protein_id="NP_390053.1" /db_xref="EnsemblGenomes-Gn:BSU21700" /db_xref="EnsemblGenomes-Tr:CAB14088" /db_xref="GOA:P54182" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11626" /db_xref="UniProtKB/Swiss-Prot:P54182" /translation="MKVRTQMMYDMETLLRKVFKQIRNEINEILDKELSRNEFTILRI LSEQGPKKVTEFAPILEVSASHITAVTDALVEKEWITRIRSKEDRRIIRIHITEAGEK VLQHFNEKKTEYFFKRFDCYTDAELATLIELFSKLDKKR*" /label="ypoP CDS" gene 1957607..1958032 /gene="ypoP" /locus_tag="BSU_21700" /old_locus_tag="BSU21700" /label="ypoP gene" downshifts 1958020 /Source="Nicolas_upshifts" /id="D1136" /incds=0 /nref=92 /ntot=248 /MaxReadThrough="4.04021" /MaxDrop="5.35086" /score="-1.90494373" /energy="-7" /TU="U1703" /idTUdmin="U1703" /TUdmin="-1254" /isTUend="FALSE" /label="downshifts" S_feature 1958065..1959296 /Source="Nicolas_S_feature" /locus_tag="new_2288652_2289883" /HighExp="Cold, ferm, nit, C30, S0, Lbstat, T3.30H, T-4.40H, T5.0H, G135" /AntisenseName="dinF" /AntisenseCor="0.270994122332881" /AntisenseRegPval="-5.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.946" /TUlongSig="NA" /TUlongPSig="NA" /label="S818" CDS complement(1958082..1959419) /gene="dinF" /locus_tag="BSU_21710" /old_locus_tag="BSU21710" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11583854, 15849754, 16850406, 22933559, 26246409; Product type t : transporter" /codon_start=1 /transl_table=11 /product="damage inducible, Na+ driven multidrug efflux pump" /protein_id="NP_390054.1" /db_xref="EnsemblGenomes-Gn:BSU21710" /db_xref="EnsemblGenomes-Tr:CAB14089" /db_xref="GOA:P54181" /db_xref="InterPro:IPR002528" /db_xref="SubtiList:BG11625" /db_xref="UniProtKB/Swiss-Prot:P54181" /translation="MKAYDFTQGNVLKQLVLFSMPIMLGNALQVSFQFIDSLWIGNLL GAKALGAAAVSSTIVLTVLSFILGLNNATLTILSQQKGKDDIKGMASYINAFVVLLTG LSIGFGAAGFFLSELLLRLLKTPESMIPLAETYLQIQFIGILFLFGYNFISTVLRALG DSKTPLRFIAFAVVLNTVLAPLFISVFRMGIAGAAYSTILSQGIAFLYGLFYVIKHKL VPFSIPRMPKWEESALILKLGIPAGLQMMVITGGMMAIMSVVNSYGDHVVSGFGAVQR LDSIITLPAMAAGTAVNSMAGQNIGIGNEKRVGTIARLGVIAVISCMLVIAVMIWVFG KYLIRLFISEPDAVAFGEQYLKWIAFFYPFIGVNFVLNGIVRAAGAMLQVLVLNLISF WVLRYPFTALFSAWLGQKGIGLGIGMSFLFSSCAAFLYYRYGRWKAMKLFTEK*" /label="dinF CDS" gene complement(1958082..1959419) /gene="dinF" /locus_tag="BSU_21710" /old_locus_tag="BSU21710" /label="dinF gene" CDS complement(1959491..1959685) /gene="ypmT" /locus_tag="BSU_21720" /old_locus_tag="BSU21720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_390055.1" /db_xref="EnsemblGenomes-Gn:BSU21720" /db_xref="EnsemblGenomes-Tr:CAB14090" /db_xref="GOA:P54180" /db_xref="InterPro:IPR035403" /db_xref="SubtiList:BG11624" /db_xref="UniProtKB/Swiss-Prot:P54180" /translation="MKRIYQYFSLLSFTFSLYFGWLAYHHLAAEDMDQMYLNVSYCAL FLSVMVFTFGMRDRKKTDKS*" /label="ypmT CDS" gene complement(1959491..1959685) /gene="ypmT" /locus_tag="BSU_21720" /old_locus_tag="BSU21720" /label="ypmT gene" downshifts complement(1959504) /Source="Nicolas_upshifts" /id="D1137" /incds=0 /nref=123 /ntot=248 /MaxReadThrough="3.84998" /MaxDrop="4.80224" /score="-2.26655222" /energy="-15.5" /TU="U1705" /idTUdmin="U1707" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1959698..1960261) /gene="ypmS" /locus_tag="BSU_21730" /old_locus_tag="BSU21730" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390056.1" /db_xref="EnsemblGenomes-Gn:BSU21730" /db_xref="EnsemblGenomes-Tr:CAB14091" /db_xref="GOA:P54179" /db_xref="InterPro:IPR018672" /db_xref="SubtiList:BG11623" /db_xref="UniProtKB/Swiss-Prot:P54179" /translation="MNKWKRLFFILLAINFILAAGFVALVLLPGEQAQVKDASESEYG FQVTSTKESLAAFVNSYLNDKASNKLDYKVEIDDDVHVAGKIKAFSTSIDAFIAFEPT VKKNGDVELNVTKFSLGKLSIPISFVLNYMDSFYELPSFVHVHPGDKSIEVRLSEMPL TNGMYVKADKINLEKDEIEFSYYHPKQ*" /label="ypmS CDS" gene complement(1959698..1960261) /gene="ypmS" /locus_tag="BSU_21730" /old_locus_tag="BSU21730" /label="ypmS gene" CDS complement(1960271..1961038) /gene="ypmR" /locus_tag="BSU_21740" /old_locus_tag="BSU21740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17220230; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative exported lipase/acylhydrolase (lipoprotein)" /protein_id="NP_390057.1" /db_xref="EnsemblGenomes-Gn:BSU21740" /db_xref="EnsemblGenomes-Tr:CAB14092" /db_xref="GOA:P40766" /db_xref="InterPro:IPR013830" /db_xref="InterPro:IPR036514" /db_xref="SubtiList:BG11022" /db_xref="UniProtKB/Swiss-Prot:P40766" /translation="MKLRIFSIMASLILLLTACTSIRTSSEGKQKAHETKTKEHIVIA AVGDSLTEGVGDPDGKGYVGKVADSIRSDKQVKTVDVKNYAVKGNRSDDLLEKLKDKK VQKGIKDADYVFFTIGGNDLMKILRQNFLQLTVEPFQEAEKPYEKRFEKIISEIRELN DHAELIYVSMYNPFTFTLSELNEINGVVTDWNHIAEKELKKDKHAKIVHIEDLFNQKS DSSRISEEDDFHPNGTGYSLIAKRVYQAIKKEGLPKE*" /label="ypmR CDS" gene complement(1960271..1961038) /gene="ypmR" /locus_tag="BSU_21740" /old_locus_tag="BSU21740" /label="ypmR gene" promotor_-10 complement(1961062..1961081) /Source="Nicolas_upshift_promotors" /id="U1705" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.735264735264735" /psig=1 /xcortree=2250 /SigmaFactorBS="aagtcagccagtacactcaagtaagctaagagactaggcaTT TGCAAAtcttctaaaaCATGATACACTTTCCACTAGtagaatgggaaggagcaacaag a" /listShort="ypmR, ypmS, ypmT, dinF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1961079) /Source="Nicolas_upshifts" /id="U1705" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.735264735264735" /psig=1 /xcortree=2250 /SigmaFactorBS="aagtcagccagtacactcaagtaagctaagagactaggcaTT TGCAAAtcttctaaaaCATGATACACTTTCCACTAGtagaatgggaaggagcaacaag a" /listShort="ypmR, ypmS, ypmT, dinF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1961092..1961099) /Source="Nicolas_upshift_promotors" /id="U1705" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.735264735264735" /psig=1 /xcortree=2250 /SigmaFactorBS="aagtcagccagtacactcaagtaagctaagagactaggcaTT TGCAAAtcttctaaaaCATGATACACTTTCCACTAGtagaatgggaaggagcaacaag a" /listShort="ypmR, ypmS, ypmT, dinF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1961116..1961697) /gene="scuA" /locus_tag="BSU_21750" /old_locus_tag="BSU21750" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10837475, 14680962, 14766920, 16305244, 19027886, 29131589" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10837475, 14680962, 14766920, 16305244, 19027886, 29131589; Product type f : factor" /codon_start=1 /transl_table=11 /product="assembly factor BSco of the Cu(A) site of cytochrome c oxidase" /protein_id="NP_390058.2" /db_xref="EnsemblGenomes-Gn:BSU21750" /db_xref="EnsemblGenomes-Tr:CAB14093" /db_xref="GOA:P54178" /db_xref="InterPro:IPR003782" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="PDB:1ON4" /db_xref="PDB:1XZO" /db_xref="SubtiList:BG11622" /db_xref="UniProtKB/Swiss-Prot:P54178" /translation="MKVIKGLTAGLIFLFLCACGGQQIKDPLNYEVEPFTFQNQDGKN VSLESLKGEVWLADFIFTNCETICPPMTAHMTDLQKKLKAENIDVRIISFSVDPENDK PKQLKKFAANYPLSFDNWDFLTGYSQSEIEEFALKSFKAIVKKPEGEDQVIHQSSFYL VGPDGKVLKDYNGVENTPYDDIISDVKSASTLK*" /label="scuA CDS" gene complement(1961116..1961697) /gene="scuA" /locus_tag="BSU_21750" /old_locus_tag="BSU21750" /label="scuA gene" S_feature complement(1961698..1961813) /Source="Nicolas_S_feature" /locus_tag="new_2292285_2292400_c" /HighExp="T5.0H, T3.30H, S2, T3.0H, BC, T2.30H, T4.0H, S1, HiOs, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S819" CDS complement(1961845..1962096) /gene="ypmP" /locus_tag="BSU_21760" /old_locus_tag="BSU21760" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15060025, 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_390059.1" /db_xref="EnsemblGenomes-Gn:BSU21760" /db_xref="EnsemblGenomes-Tr:CAB14094" /db_xref="InterPro:IPR019687" /db_xref="SubtiList:BG11621" /db_xref="UniProtKB/Swiss-Prot:P54177" /translation="MLLKSLEFKRGDGIQVKVTEIPVLKEDEHYFFMLHHHLQFYLKE VFSSNSRAKVYSFRHYMKRRMKWADYQAVFHQEVLKHNA*" /label="ypmP CDS" gene complement(1961845..1962096) /gene="ypmP" /locus_tag="BSU_21760" /old_locus_tag="BSU21760" /label="ypmP gene" downshifts complement(1961858) /Source="Nicolas_upshifts" /id="D1138" /incds=0 /nref=2 /ntot=117 /MaxReadThrough="4.5803" /MaxDrop="2.91481" /score="26.0320926" /energy="-21.8" /TU="U1707" /idTUdmin="U1706" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(1962119..1962138) /Source="Nicolas_upshift_promotors" /id="U1706" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=626 /SigmaFactorBS="ttgctaatctaatttttttacacaaccgcgcaaaatgacaga cagcccggctggcATCATATATAATAGAAGAAAaacaaaaaagaggattgatagcttg t" /listShort="ypmP" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1962133) /Source="Nicolas_upshifts" /id="U1706" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=626 /SigmaFactorBS="ttgctaatctaatttttttacacaaccgcgcaaaatgacaga cagcccggctggcATCATATATAATAGAAGAAAaacaaaaaagaggattgatagcttg t" /listShort="ypmP" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1962182..1963450) /gene="ilvA" /locus_tag="BSU_21770" /old_locus_tag="BSU21770" /EC_number="4.3.1.19" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12618455, 13878122, 1459955, 15060025, 18855421, 22094463, 27260660" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12618455, 13878122, 1459955, 15060025, 18855421, 22094463, 27260660; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="threonine dehydratase" /protein_id="NP_390060.1" /db_xref="EnsemblGenomes-Gn:BSU21770" /db_xref="EnsemblGenomes-Tr:CAB14095" /db_xref="GOA:P37946" /db_xref="InterPro:IPR000634" /db_xref="InterPro:IPR001721" /db_xref="InterPro:IPR001926" /db_xref="InterPro:IPR011820" /db_xref="InterPro:IPR036052" /db_xref="SubtiList:BG10673" /db_xref="UniProtKB/Swiss-Prot:P37946" /translation="MKPLLKENSLIQVKDILKAHQNVKDVVIHTPLQRNDRLSERYEC NIYLKREDLQVVRSFKLRGAYHKMKQLSSEQTENGVVCASAGNHAQGVAFSCKHLGIH GKIFMPSTTPRQKVSQVELFGKGFIDIILTGDTFDDAYKSAAECCEAESRTFIHPFDD PDVMAGQGTLAVEILNDIDTEPHFLFASVGGGGLLSGVGTYLKNVSPDTKVIAVEPAG AASYFESNKAGHVVTLDKIDKFVDGAAVKKIGEETFRTLETVVDDILLVPEGKVCTSI LELYNECAVVAEPAGALSVAALDLYKDQIKGKNVVCVVSGGNNDIGRMQEMKERSLIF EGLQHYFIVNFPQRAGALREFLDEVLGPNDDITRFEYTKKNNKSNGPALVGIELQNKA DYGPLIERMNKKPFHYVEVNKDEDLFHLLI*" /label="ilvA CDS" gene complement(1962182..1963450) /gene="ilvA" /locus_tag="BSU_21770" /old_locus_tag="BSU21770" /label="ilvA gene" promotor_-10 complement(1963484..1963503) /Source="Nicolas_upshift_promotors" /id="U1707" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.754245754245754" /psig="0.999000999001" /xcortree=2906 /SigmaFactorBS="gacatagtctgtatttttttaattattaaataaaaataattG TCTTATTttttgaatattCATGTTATAATGGCATATTAaatagggatttaaaacaaga a" /listShort="ilvA, ypmP, S819, scuA, ypmR, ypmS, ypmT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1963503) /Source="Nicolas_upshifts" /id="U1707" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.754245754245754" /psig="0.999000999001" /xcortree=2906 /SigmaFactorBS="gacatagtctgtatttttttaattattaaataaaaataattG TCTTATTttttgaatattCATGTTATAATGGCATATTAaatagggatttaaaacaaga a" /listShort="ilvA, ypmP, S819, scuA, ypmR, ypmS, ypmT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1963515..1963522) /Source="Nicolas_upshift_promotors" /id="U1707" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.754245754245754" /psig="0.999000999001" /xcortree=2906 /SigmaFactorBS="gacatagtctgtatttttttaattattaaataaaaataattG TCTTATTttttgaatattCATGTTATAATGGCATATTAaatagggatttaaaacaaga a" /listShort="ilvA, ypmP, S819, scuA, ypmR, ypmS, ypmT" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 1963657..1963676 /Source="Nicolas_upshift_promotors" /id="U1708" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3088 /SigmaFactorBS="cctgcagagccaagaaaaaagatgatcgtaaaataaagggtg ttttcaaccaaaaggCATGATATAATGAAACCAATtagaaccaaaaggagccaattga t" /listShort="yplP, yplQ, S820" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1963660 /Source="Nicolas_upshifts" /id="U1708" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3088 /SigmaFactorBS="cctgcagagccaagaaaaaagatgatcgtaaaataaagggtg ttttcaaccaaaaggCATGATATAATGAAACCAATtagaaccaaaaggagccaattga t" /listShort="yplP, yplQ, S820" /GFF_Attribute="listLong" /label="upshifts" CDS 1963699..1964694 /gene="silP" /locus_tag="BSU_21780" /old_locus_tag="BSU21780" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12399512, 16585774, 19763274" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12399512, 16585774, 19763274; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional enhancer involved in BCAA homeostasis" /protein_id="NP_390061.1" /db_xref="EnsemblGenomes-Gn:BSU21780" /db_xref="EnsemblGenomes-Tr:CAB14096" /db_xref="GOA:P54156" /db_xref="InterPro:IPR002078" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013668" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11619" /db_xref="UniProtKB/Swiss-Prot:P54156" /translation="MNSAPKLNTFQHLIGEHQTFLEAKRIAKQFSLSELPVLITGKIG TGKNHFAHAIHLESSRSNEPFISVNCSTHSEETLIHELFGPNGNTGVFQKAVRGTLFL DDVWRMPASVQAQLLKALDSDTEKPRMICASADRSVEHTFRQDLFYRLNILTLTLPEL SERKSDIPLLTQHFLSNSGQQLLIDPSVFPVLEKHAFEGNVRELKNAADYMAAVSSGG TIQPYDLPPYIRGTIDGKTSKKKAKLLTLMEKAEFLFILETIKVLNEKGEPASRRIIS EHSKNTQTSLTPQQVRSRLDYLEKKDYVTKSRGRAGTKITFEGLSFIETLKNQMI*" /label="silP CDS" gene 1963699..1964694 /gene="silP" /locus_tag="BSU_21780" /old_locus_tag="BSU21780" /label="silP gene" CDS 1964715..1965356 /gene="yplQ" /locus_tag="BSU_21790" /old_locus_tag="BSU21790" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16585774, 16850406, 19763274; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane hydrolase" /protein_id="NP_390062.1" /db_xref="EnsemblGenomes-Gn:BSU21790" /db_xref="EnsemblGenomes-Tr:CAB14097" /db_xref="GOA:P54175" /db_xref="InterPro:IPR004254" /db_xref="InterPro:IPR005744" /db_xref="SubtiList:BG11620" /db_xref="UniProtKB/Swiss-Prot:P54175" /translation="MFTIKEEIANAITHGIGVLLSIPALVFLIIFAANYGSAWDIVSF TIFGVSMLLLYLSSTLLHSITHKKTKDILEIIDHSAIYVLIAGTYTPFLLGPLKGTLG FTLLVIVWSLALGGIVFKIFFVKRFILLSTFVYLVMGWLMIIAVKPLYASLSGAGFSL LFLGGILYSVGTIFYIWKKIPFHHAIWHSFVLGGSAAMFFCVLFYCVKVPFLS*" /label="yplQ CDS" gene 1964715..1965356 /gene="yplQ" /locus_tag="BSU_21790" /old_locus_tag="BSU21790" /label="yplQ gene" S_feature 1965357..1966458 /Source="Nicolas_S_feature" /locus_tag="new_2295944_2297045" /HighExp="Cold, C30, Sw, BC, G135, LoTm, Fru, C90, BI, S0" /AntisenseName="ypkP" /AntisenseCor="0.28434605181220002" /AntisenseRegPval="-5.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S820" CDS complement(1965395..1966015) /gene="ypkP" /locus_tag="BSU_21800" /old_locus_tag="BSU21800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 1-acyl-sn-glycerol-3-phosphate acyltransferase" /protein_id="NP_390063.2" /db_xref="EnsemblGenomes-Gn:BSU21800" /db_xref="EnsemblGenomes-Tr:CAB14098" /db_xref="SubtiList:BG11618" /db_xref="UniProtKB/Swiss-Prot:P54174" /translation="MVRYSLLVVYIVYMLLKNMKQLFNQTMLDPRLSYKKQMALVYEQ PKAFLEGCIGISGSVVTIHQPEPIPHGPVLYVHPRLRLAELALIAGYIEEPAGFIANP KVFRLPFIGQWLDRMDVISDGDSEKVYEDVTKQLEKGQSLILSLDGSIDPVELAARYH LPLVMVETKGTDNMQNGSFFKRLKPADIELSFSKAYIPANEKQLRA*" /label="ypkP CDS" gene complement(1965395..1966015) /gene="ypkP" /locus_tag="BSU_21800" /old_locus_tag="BSU21800" /label="ypkP gene" downshifts complement(1965421) /Source="Nicolas_upshifts" /id="D1139" /incds=0 /nref=72 /ntot=241 /MaxReadThrough="1.32187" /MaxDrop="5.02823" /score="16.0584527" /energy="-13.4" /TU="NA" /idTUdmin="U1710" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" CDS complement(1966016..1966522) /gene="dfrA" /locus_tag="BSU_21810" /old_locus_tag="BSU21810" /EC_number="1.5.1.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2840350, 3918568, 10574451, 12682299, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2840350, 3918568, 10574451, 12682299, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydrofolate reductase" /protein_id="NP_390064.1" /db_xref="EnsemblGenomes-Gn:BSU21810" /db_xref="EnsemblGenomes-Tr:CAB14099" /db_xref="GOA:P11045" /db_xref="InterPro:IPR001796" /db_xref="InterPro:IPR012259" /db_xref="InterPro:IPR017925" /db_xref="InterPro:IPR024072" /db_xref="SubtiList:BG10795" /db_xref="UniProtKB/Swiss-Prot:P11045" /translation="MISFIFAMDANRLIGKDNDLPWHLPNDLAYFKKITSGHSIIMGR KTFESIGRPLPNRKNIVVTSAPDSEFQGCTVVSSLKDVLDICSGPEECFVIGGAQLYT DLFPYADRLYMTKIHHEFEGDRHFPEFDESNWKLVSSEQGTKDEKNPYDYEFLMYEKK NSSKAGGF*" /label="dfrA CDS" gene complement(1966016..1966522) /gene="dfrA" /locus_tag="BSU_21810" /old_locus_tag="BSU21810" /label="dfrA gene" CDS complement(1966519..1967313) /gene="thyB" /locus_tag="BSU_21820" /old_locus_tag="BSU21820" /EC_number="2.1.1.45" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9648749, 10574451, 19732150" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9648749, 10574451, 19732150; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thymidylate synthase B" /protein_id="NP_390065.1" /db_xref="EnsemblGenomes-Gn:BSU21820" /db_xref="EnsemblGenomes-Tr:CAB14100" /db_xref="GOA:P11044" /db_xref="InterPro:IPR000398" /db_xref="InterPro:IPR020940" /db_xref="InterPro:IPR023451" /db_xref="InterPro:IPR036926" /db_xref="SubtiList:BG10794" /db_xref="UniProtKB/Swiss-Prot:P11044" /translation="MKQYKDFCRHVLEHGEKKGDRTGTGTISTFGYQMRFNLREGFPM LTTKKLHFKSIAHELLWFLKGDTNVRYLQENGVRIWNEWADENGELGPVYGSQWRSWR GADGETIDQISRLIEDIKTNPNSRRLIVSAWNVGEIDKMALPPCHCLFQFYVSDGKLS CQLYQRSADVFLGVPFNIASYALLTMIIAHVTGLEPGEFIHTFGDVHIYQNHIEQVNL QLERDVRPLPQLRFARKVDSIFNFAFEDFIIEDYDPHPHIKGAVSV*" /label="thyB CDS" gene complement(1966519..1967313) /gene="thyB" /locus_tag="BSU_21820" /old_locus_tag="BSU21820" /label="thyB gene" CDS complement(1967397..1967930) /gene="ypjQ" /locus_tag="BSU_21830" /old_locus_tag="BSU21830" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8534098; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphatidylglycerophosphatase" /protein_id="NP_390066.1" /db_xref="EnsemblGenomes-Gn:BSU21830" /db_xref="EnsemblGenomes-Tr:CAB14101" /db_xref="GOA:P54173" /db_xref="InterPro:IPR007686" /db_xref="InterPro:IPR026038" /db_xref="InterPro:IPR036681" /db_xref="PDB:1TLQ" /db_xref="SubtiList:BG11617" /db_xref="UniProtKB/Swiss-Prot:P54173" /translation="MKKYTMNEMVDITKDMLNKRGVMIEDIARIVQKLQEKYNPNLPL SVCMENVEKVLNKREIIHAVLTGLALDQLAEQKLLPEPLQHLVETDEPLYGIDEIIPL SIVNVYGSIGLTNFGYLDKEKIGIIKELDESPDGIHTFLDDIVAALAAAAASRIAHTH QDLQDEEKEQDEKPVVS*" /label="ypjQ CDS" gene complement(1967397..1967930) /gene="ypjQ" /locus_tag="BSU_21830" /old_locus_tag="BSU21830" /label="ypjQ gene" downshifts complement(1967402) /Source="Nicolas_upshifts" /id="D1140" /incds=0 /nref=17 /ntot=167 /MaxReadThrough="4.91561" /MaxDrop="4.18561" /score="15.5758445" /energy="-9.3" /TU="U1710" /idTUdmin="U1711" /TUdmin=1232 /isTUend="FALSE" /label="downshifts" promotor_-35 1967860..1967865 /Source="Nicolas_upshift_promotors" /id="U1709" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1113 /SigmaFactorBS="tatttttcctgaagtttttgaacaatccgtgcaatatcttct ATCATAacgccccgtttgttcaGCATATCCTTTGTTATATCgaccatttcattcattg t" /listShort="S821" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1967876..1968822 /Source="Nicolas_S_feature" /locus_tag="new_2298463_2299409" /HighExp="S5, S6, S4, S8, S7, S3, B36, BT, B60, T5.0H" /AntisenseName="ypjP" /AntisenseCor="-0.72590712604537599" /AntisenseRegPval="-44.6" /CDS_PredictionProba="0.99932399999999999" /TUshortSig="SigEF" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S821" upshifts 1967878 /Source="Nicolas_upshifts" /id="U1709" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1113 /SigmaFactorBS="tatttttcctgaagtttttgaacaatccgtgcaatatcttct ATCATAacgccccgtttgttcaGCATATCCTTTGTTATATCgaccatttcattcattg t" /listShort="S821" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1967882..1967900 /Source="Nicolas_upshift_promotors" /id="U1709" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1113 /SigmaFactorBS="tatttttcctgaagtttttgaacaatccgtgcaatatcttct ATCATAacgccccgtttgttcaGCATATCCTTTGTTATATCgaccatttcattcattg t" /listShort="S821" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(1967948..1968559) /gene="ypjP" /locus_tag="BSU_21840" /old_locus_tag="BSU21840" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_390067.1" /db_xref="EnsemblGenomes-Gn:BSU21840" /db_xref="EnsemblGenomes-Tr:CAB14102" /db_xref="GOA:P54172" /db_xref="InterPro:IPR025616" /db_xref="SubtiList:BG11616" /db_xref="UniProtKB/Swiss-Prot:P54172" /translation="MKLWMRKTLVVLFTIVTFGLVSPPAALMADKPSGQPSSLEQNDY TAFYDEHDLYDDESDDRRDPELLFQSYKEQLLDSAEDQSFLKFGSRIAPVIEDDYRKE ILPKIENVISDYLATLQDDEAYQDVVISSMPSAGKTEKIFNVYNRTTGEDLLRFHVRR DHPPHDGYWFNFHYHTAEDGFQSHHELGSIYWDRNTPPNWMSA*" /label="ypjP CDS" gene complement(1967948..1968559) /gene="ypjP" /locus_tag="BSU_21840" /old_locus_tag="BSU21840" /label="ypjP gene" promotor_-10 complement(1968591..1968610) /Source="Nicolas_upshift_promotors" /id="U1710" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2276 /SigmaFactorBS="gcaacgaatctcctaatttgcatatcagtttcatatagtaca TGACTTgcatgttttggaTGTGCTAAAATAAGAGAAACatgacaataaaatagagagg a" /listShort="ypjP, ypjQ, thyB, dfrA, ypkP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1968610) /Source="Nicolas_upshifts" /id="U1710" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2276 /SigmaFactorBS="gcaacgaatctcctaatttgcatatcagtttcatatagtaca TGACTTgcatgttttggaTGTGCTAAAATAAGAGAAACatgacaataaaatagagagg a" /listShort="ypjP, ypjQ, thyB, dfrA, ypkP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1968623..1968628) /Source="Nicolas_upshift_promotors" /id="U1710" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2276 /SigmaFactorBS="gcaacgaatctcctaatttgcatatcagtttcatatagtaca TGACTTgcatgttttggaTGTGCTAAAATAAGAGAAACatgacaataaaatagagagg a" /listShort="ypjP, ypjQ, thyB, dfrA, ypkP" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1968779 /Source="Nicolas_upshifts" /id="D1141" /incds=0 /nref=57 /ntot=234 /MaxReadThrough="3.131" /MaxDrop="5.18613" /score="2.81720493" /energy="-15" /TU="U1709" /idTUdmin="U1709" /TUdmin="-527" /isTUend="FALSE" /label="downshifts" CDS complement(1968819..1969592) /gene="rsmJ" /locus_tag="BSU_21850" /old_locus_tag="BSU21850" /EC_number="2.1.1.242" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22079366; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 16S rRNA m(2)G1516 methyltransferase" /protein_id="NP_390068.2" /db_xref="EnsemblGenomes-Gn:BSU21850" /db_xref="EnsemblGenomes-Tr:CAB14103" /db_xref="GOA:P54171" /db_xref="InterPro:IPR007536" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11615" /db_xref="UniProtKB/Swiss-Prot:P54171" /translation="MITTSYRPSEHTIKTAKQLSKELNMPYCGRNKQTVEHLLKSAER DLLVVGKERFELYTKQGAKFFFHPNTAMFRAKRFLQGEKEPMLRAAGLSEGDTFLDCT LGLGSDAIIASMAVGETGSVVGIEKNHLVSVLVRTGLHSWETGIEELQAAMRRIQVKN GDCFEHIKQLPDNSVDVVYFDPMFHEPVETSDGIAPLRDLAEDSVLHEGCINEAVRVA RKSVVLKDHWKSPRFEQFGFNVMKRKTALFHYGVIQTSP*" /label="rsmJ CDS" gene complement(1968819..1969592) /gene="rsmJ" /locus_tag="BSU_21850" /old_locus_tag="BSU21850" /label="rsmJ gene" downshifts complement(1968854) /Source="Nicolas_upshifts" /id="D1142" /incds=0 /nref=1 /ntot=66 /MaxReadThrough="2.86923" /MaxDrop="2.91228" /score="9.10717118" /energy="-15" /TU="U1711" /idTUdmin="U1711" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" CDS complement(1969634..1970068) /gene="brxA" /locus_tag="BSU_21860" /old_locus_tag="BSU21860" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:19653655, 21749987, 22938038, 24313874, 28301954" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19653655, 21749987, 22938038, 24313874, 28301954; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein disulfide isomerase; bacilliredoxin A (de-bacillithiolation)" /protein_id="NP_390069.1" /db_xref="EnsemblGenomes-Gn:BSU21860" /db_xref="EnsemblGenomes-Tr:CAB14104" /db_xref="InterPro:IPR009474" /db_xref="PDB:3FHK" /db_xref="SubtiList:BG11614" /db_xref="UniProtKB/Swiss-Prot:P54170" /translation="MSMAYEEYMRQLVVPMRRELTGAGFEELTTAEEVENFMEKAEGT TLVVVNSVCGCAAGLARPAATQAVLQNDKTPDNTVTVFAGQDKEATAKMREYFTGQEP SSPSMALLKGKEVVHFIPRHEIEGHDMEEIMKNLTAAFDAHC*" /label="brxA CDS" gene complement(1969634..1970068) /gene="brxA" /locus_tag="BSU_21860" /old_locus_tag="BSU21860" /label="brxA gene" downshifts complement(1969646) /Source="Nicolas_upshifts" /id="D1143" /incds=0 /nref=9 /ntot=210 /MaxReadThrough="5.2935" /MaxDrop="3.1992" /score="21.0933404" /energy="-9.7" /TU="U1711,U1712" /idTUdmin="U1712" /TUdmin="-462" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1970097..1970116) /Source="Nicolas_upshift_promotors" /id="U1711" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.972027972027972" /psig="0.997002997002997" /xcortree=1933 /SigmaFactorBS="ggggacactttcttttattttaaggcgtgaaCATTTGAAatc cggccctctcTATAGTATCCTTTACTTCAGatgaaggatactagagggggcttttttt a" /listShort="yphP, ypiP" /listLong="ypjP, ypjQ, thyB, dfrA, ypkP" /label="promotor_-10" upshifts complement(1970108) /Source="Nicolas_upshifts" /id="U1711" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.972027972027972" /psig="0.997002997002997" /xcortree=1933 /SigmaFactorBS="ggggacactttcttttattttaaggcgtgaaCATTTGAAatc cggccctctcTATAGTATCCTTTACTTCAGatgaaggatactagagggggcttttttt a" /listShort="yphP, ypiP" /listLong="ypjP, ypjQ, thyB, dfrA, ypkP" /label="upshifts" S_feature complement(1970110..1970174) /Source="Nicolas_S_feature" /locus_tag="new_2300697_2300761_c" /HighExp="Sw, S1, BC, Gly, HiOs, HiTm, GM-0.1, UNK1, Fru, MG 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S822" promotor_-35 complement(1970130..1970137) /Source="Nicolas_upshift_promotors" /id="U1711" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.972027972027972" /psig="0.997002997002997" /xcortree=1933 /SigmaFactorBS="ggggacactttcttttattttaaggcgtgaaCATTTGAAatc cggccctctcTATAGTATCCTTTACTTCAGatgaaggatactagagggggcttttttt a" /listShort="yphP, ypiP" /listLong="ypjP, ypjQ, thyB, dfrA, ypkP" /label="promotor_-35" downshifts complement(1970153) /Source="Nicolas_upshifts" /id="D1144" /incds=0 /nref=32 /ntot=128 /MaxReadThrough="5.73826" /MaxDrop="4.95094" /score="26.9702838" /energy="-25.8" /TU="U1712" /idTUdmin="U1713" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1970175..1971851) /gene="ilvD" /locus_tag="BSU_21870" /old_locus_tag="BSU21870" /EC_number="4.2.1.9" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12193635, 12618455, 15060025, 24163341" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12193635, 12618455, 15060025, 24163341; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydroxy-acid dehydratase" /protein_id="NP_390070.2" /db_xref="EnsemblGenomes-Gn:BSU21870" /db_xref="EnsemblGenomes-Tr:CAB14105" /db_xref="GOA:P51785" /db_xref="InterPro:IPR000581" /db_xref="InterPro:IPR004404" /db_xref="InterPro:IPR015928" /db_xref="InterPro:IPR020558" /db_xref="SubtiList:BG11532" /db_xref="UniProtKB/Swiss-Prot:P51785" /translation="MAELRSNMITQGIDRAPHRSLLRAAGVKEEDFGKPFIAVCNSYI DIVPGHVHLQEFGKIVKEAIREAGGVPFEFNTIGVDDGIAMGHIGMRYSLPSREIIAD SVETVVSAHWFDGMVCIPNCDKITPGMLMAAMRINIPTIFVSGGPMAAGRTSDGRKIS LSSVFEGVGAYQAGKINENELQELEQFGCPTCGSCSGMFTANSMNCLSEALGLALPGN GTILATSPERKEFVRKSAAQLMETIRKDIKPRDIVTVKAIDNAFALDMALGGSTNTVL HTLALANEAGVEYSLERINEVAERVPHLAKLAPASDVFIEDLHEAGGVSAALNELSKK EGALHLDALTVTGKTLGETIAGHEVKDYDVIHPLDQPFTEKGGLAVLFGNLAPDGAII KTGGVQNGITRHEGPAVVFDSQDEALDGIINRKVKEGDVVIIRYEGPKGGPGMPEMLA PTSQIVGMGLGPKVALITDGRFSGASRGLSIGHVSPEAAEGGPLAFVENGDHIIVDIE KRILDVQVPEEEWEKRKANWKGFEPKVKTGYLARYSKLVTSANTGGIMKI*" /label="ilvD CDS" gene complement(1970175..1971851) /gene="ilvD" /locus_tag="BSU_21870" /old_locus_tag="BSU21870" /label="ilvD gene" S_feature complement(1971852..1972042) /Source="Nicolas_S_feature" /locus_tag="new_2302439_2302629_c" /HighExp="S1, T-5.40H, MG 45, HiOs, T-4.40H, MG 120, UNK1, MG 25, MG-0.2, GM-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 0.97" /TUlongSig="SigH" /TUlongPSig=1 /label="S823" promotor_-10 complement(1972031..1972050) /Source="Nicolas_upshift_promotors" /id="U1712" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.555444555444555" /psig="0.997002997002997" /xcortree=2910 /SigmaFactorBS="gaattcactttttataaaaattatttcgaatattGTTGaaaa atatccgaaaACTATTTATAGTAAGTAACAatattaatagttggagggttcaaatcga a" /listShort="S823, ilvD, S822, yphP, ypiP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1972042) /Source="Nicolas_upshifts" /id="U1712" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.555444555444555" /psig="0.997002997002997" /xcortree=2910 /SigmaFactorBS="gaattcactttttataaaaattatttcgaatattGTTGaaaa atatccgaaaACTATTTATAGTAAGTAACAatattaatagttggagggttcaaatcga a" /listShort="S823, ilvD, S822, yphP, ypiP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1972065..1972068) /Source="Nicolas_upshift_promotors" /id="U1712" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.555444555444555" /psig="0.997002997002997" /xcortree=2910 /SigmaFactorBS="gaattcactttttataaaaattatttcgaatattGTTGaaaa atatccgaaaACTATTTATAGTAAGTAACAatattaatagttggagggttcaaatcga a" /listShort="S823, ilvD, S822, yphP, ypiP" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1972140..1973273) /gene="ypgR" /locus_tag="BSU_21880" /old_locus_tag="BSU21880" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lyase or scaffold" /protein_id="NP_390071.1" /db_xref="EnsemblGenomes-Gn:BSU21880" /db_xref="EnsemblGenomes-Tr:CAB14106" /db_xref="InterPro:IPR004155" /db_xref="InterPro:IPR014824" /db_xref="InterPro:IPR016024" /db_xref="InterPro:IPR025989" /db_xref="InterPro:IPR036498" /db_xref="SubtiList:BG11613" /db_xref="UniProtKB/Swiss-Prot:P54169" /translation="MKIKSIEPTPSPNTMKVILTEELPAGKSNNYKPEQAEGAPLVIA EILKIDGVKGVYHVADFLAVERNARYDWKDILPQVRTAFGMESAESAEENRSDQESFG EVKVFVQMFSGIPMQVKLTDGEREERFGLPERFQQAILKLRSEASNVVFERAWKEQGV RFGDFDEIGHDVTEELQAAYSDERLKRLTEAAAQGKGEAKQAVQRKAYKVTLDMLDDE DWKKRYAHLEQMDPKEEDIPVLQKALDDPKVSIRRQAVVYLGMIETPDVLPLLYKALE DKAVSVRRTAGDCLSDIGDPQAIPAMIKSLSDSSKLVRWRAAMFLYEVGDESAIEALR AAEDDPEFEVSLQVKMALERIEHGEEAKGSVWKQMTESRKKGE*" /label="ypgR CDS" gene complement(1972140..1973273) /gene="ypgR" /locus_tag="BSU_21880" /old_locus_tag="BSU21880" /label="ypgR gene" downshifts complement(1972156) /Source="Nicolas_upshifts" /id="D1145" /incds=0 /nref=193 /ntot=249 /MaxReadThrough="5.33526" /MaxDrop="6.88149" /score="18.2078317" /energy="-8.7" /TU="U1713" /idTUdmin="U1714" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" misc_feature complement(1973295..1973314) /Source="Nicolas_upshift_promotors" /id="U1713" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.618381618381618" /psig="0.97002997002997" /xcortree=1972 /SigmaFactorBS="ccgggattgatgccgaaacgtcgtaatagaaggcttggagcg acTATGATAGAATAAGTCACAGatatgctataggaggacgatcatgaagataaaatca a" /listShort="ypgR, S823, ilvD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1973298) /Source="Nicolas_upshifts" /id="U1713" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.618381618381618" /psig="0.97002997002997" /xcortree=1972 /SigmaFactorBS="ccgggattgatgccgaaacgtcgtaatagaaggcttggagcg acTATGATAGAATAAGTCACAGatatgctataggaggacgatcatgaagataaaatca a" /listShort="ypgR, S823, ilvD" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1973333..1973950) /gene="hdhQ" /locus_tag="BSU_21890" /old_locus_tag="BSU21890" /EC_number="3.6.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:25005104, 27062940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25005104, 27062940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Mn(2+)-dependent (deoxy)ribonucleoside pyrophosphohydrolase" /protein_id="NP_390072.1" /db_xref="EnsemblGenomes-Gn:BSU21890" /db_xref="EnsemblGenomes-Tr:CAB14107" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR006674" /db_xref="SubtiList:BG11612" /db_xref="UniProtKB/Swiss-Prot:P54168" /translation="MKELKQAEQIRTWVQSILTDESSGHDWHHVSRVADLAAYIGEKE KADLFIVETAALVHDLIDVKLPDTVRLSVSEVYDQLVFFGVGKENADRVIHIITRMSF RDRGKLAKEPLSIEGKAVQDADRLDAIGAVGIARAFMFAGAKGHGLYGDEQSAYAHFF HKLLRLKDMMNTDTARELAEERHNFMLQFVRQLEKDIPGIDAETS*" /label="hdhQ CDS" gene complement(1973333..1973950) /gene="hdhQ" /locus_tag="BSU_21890" /old_locus_tag="BSU21890" /label="hdhQ gene" CDS complement(1973966..1974448) /gene="bsaA" /locus_tag="BSU_21900" /old_locus_tag="BSU21900" /EC_number="1.11.1.-" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 14563871, 14617062, 21749987, 25852656; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bacillithiol peroxidase" /protein_id="NP_390073.1" /db_xref="EnsemblGenomes-Gn:BSU21900" /db_xref="EnsemblGenomes-Tr:CAB14108" /db_xref="GOA:P52035" /db_xref="InterPro:IPR000889" /db_xref="InterPro:IPR029759" /db_xref="InterPro:IPR029760" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG11530" /db_xref="UniProtKB/Swiss-Prot:P52035" /translation="MSIYHMKVRTITGKDMTLQPFAGKVLMIVNTASKCGFTSQLKQL QELYDTYQQEGLEILGFPCNQFMNQEPGEEADIQEFCETNYGVTFPMFSKVDVNGKNA HPLFVYLTEHAKGMLGTKAIKWNFTKFIVDRNGEIVGRYSPNTNPKELEDDIVKLLEQ *" /label="bsaA CDS" gene complement(1973966..1974448) /gene="bsaA" /locus_tag="BSU_21900" /old_locus_tag="BSU21900" /label="bsaA gene" S_feature complement(1974449..1974596) /Source="Nicolas_S_feature" /locus_tag="new_2305036_2305183_c" /HighExp="S2, HiOs, S1, Etha, T2.30H, T3.0H, Lbtran, M0t90, T2.0H, SMMPr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S824" promotor_-10 complement(1974587..1974605) /Source="Nicolas_upshift_promotors" /id="U1714" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=3200 /SigmaFactorBS="tggtttcacagtaaaatgattttcaaagatgtaAGAGGGAAT tgtaatgtttTATAGAATGATAAGATAAAaaacgagccatatgaattgataatgaact g" /listShort="S824, bsaA, ypgQ, ypgR" /listLong="S823, ilvD" /label="promotor_-10" upshifts complement(1974597) /Source="Nicolas_upshifts" /id="U1714" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=3200 /SigmaFactorBS="tggtttcacagtaaaatgattttcaaagatgtaAGAGGGAAT tgtaatgtttTATAGAATGATAAGATAAAaaacgagccatatgaattgataatgaact g" /listShort="S824, bsaA, ypgQ, ypgR" /listLong="S823, ilvD" /label="upshifts" promotor_-35 complement(1974616..1974624) /Source="Nicolas_upshift_promotors" /id="U1714" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=3200 /SigmaFactorBS="tggtttcacagtaaaatgattttcaaagatgtaAGAGGGAAT tgtaatgtttTATAGAATGATAAGATAAAaaacgagccatatgaattgataatgaact g" /listShort="S824, bsaA, ypgQ, ypgR" /listLong="S823, ilvD" /label="promotor_-35" promotor_-35 1974650..1974659 /Source="Nicolas_upshift_promotors" /id="U1715" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1652 /SigmaFactorBS="caattccctcttacatctttgaaaatcattttactgTGAAAC CAAAaggcgtgtcagtGCGTTTTATTTAAAGAgttttctgttgtttccccctcaacac g" /listShort="S825, metA, S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="promotor_-35" promotor_-10 1974672..1974687 /Source="Nicolas_upshift_promotors" /id="U1715" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1652 /SigmaFactorBS="caattccctcttacatctttgaaaatcattttactgTGAAAC CAAAaggcgtgtcagtGCGTTTTATTTAAAGAgttttctgttgtttccccctcaacac g" /listShort="S825, metA, S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="promotor_-10" S_feature 1974674..1974760 /Source="Nicolas_S_feature" /locus_tag="new_2305261_2305347" /HighExp="Salt, T-0.40H, T-1.10H, Heat, T-1.40H, H2O2, T0.0H, Paraq, T0.30H, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S825" upshifts 1974674 /Source="Nicolas_upshifts" /id="U1715" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1652 /SigmaFactorBS="caattccctcttacatctttgaaaatcattttactgTGAAAC CAAAaggcgtgtcagtGCGTTTTATTTAAAGAgttttctgttgtttccccctcaacac g" /listShort="S825, metA, S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="upshifts" promotor_-35 1974723..1974730 /Source="Nicolas_upshift_promotors" /id="U1716" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.612387612387612" /psig="0.995004995004995" /xcortree=2257 /SigmaFactorBS="ccccctcaacacgtatagataGATTGAAAattggcgtgaaaa tTCCTATAATGAAGAAAATTAaacggggaaataatggaggtggcacgttgcctattaa t" /listShort="metA, S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="promotor_-35" promotor_-10 1974745..1974764 /Source="Nicolas_upshift_promotors" /id="U1716" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.612387612387612" /psig="0.995004995004995" /xcortree=2257 /SigmaFactorBS="ccccctcaacacgtatagataGATTGAAAattggcgtgaaaa tTCCTATAATGAAGAAAATTAaacggggaaataatggaggtggcacgttgcctattaa t" /listShort="metA, S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="promotor_-10" upshifts 1974762 /Source="Nicolas_upshifts" /id="U1716" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.612387612387612" /psig="0.995004995004995" /xcortree=2257 /SigmaFactorBS="ccccctcaacacgtatagataGATTGAAAattggcgtgaaaa tTCCTATAATGAAGAAAATTAaacggggaaataatggaggtggcacgttgcctattaa t" /listShort="metA, S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="upshifts" CDS 1974791..1975696 /gene="metAA" /locus_tag="BSU_21910" /old_locus_tag="BSU21910" /EC_number="2.3.1.31" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:5001847, 10939241, 11832514, 17056751, 18216013, 28581482" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 5001847, 10939241, 11832514, 17056751, 18216013, 28581482; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="homoserine O-acetyltransferase" /protein_id="NP_390074.2" /db_xref="EnsemblGenomes-Gn:BSU21910" /db_xref="EnsemblGenomes-Tr:CAB14109" /db_xref="GOA:P54167" /db_xref="InterPro:IPR005697" /db_xref="InterPro:IPR029062" /db_xref="InterPro:IPR033752" /db_xref="SubtiList:BG11534" /db_xref="UniProtKB/Swiss-Prot:P54167" /translation="MPINIPTHLPAKQVLESEHIFVMDESRAFHQDIRPQKIIILNLM PKKIQTETQLLRLLGNSPLQVHFTFLIPSTHTPKNTAREHLDEFYTTFSNIRHKRFDG MIITGAPIEHLAFEEVSYWEELKEIMEWSKTNVTSTLHICWGAQAGLYYHYGVEKIQM PKKIFGVFEHTVLSKHERLVRGFDELYYVPHSRHTDINMEQLQAVPELNILTASKEAG VCLIVSKDEKQVFLTGHPEYDTNTLLQEYERDLERNLSTVEAPKHYFAKGSNEPVNRW KAHATLLFMNWLNYYVYQETPYEWD*" /label="metAA CDS" gene 1974791..1975696 /gene="metAA" /locus_tag="BSU_21910" /old_locus_tag="BSU21910" /label="metAA gene" misc_feature 1975731..1975750 /Source="Nicolas_upshift_promotors" /id="U1717" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.982017982017982" /psig="0.999000999001" /xcortree=2287 /SigmaFactorBS="gaatgggactaatttttctttttttagtgatacgctgagcaa aaaaTATGATAAAATACATCTGATtcagtctgcgtataacaaaaatttaaaatactgg a" /listShort="S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1975745 /Source="Nicolas_upshifts" /id="U1717" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.982017982017982" /psig="0.999000999001" /xcortree=2287 /SigmaFactorBS="gaatgggactaatttttctttttttagtgatacgctgagcaa aaaaTATGATAAAATACATCTGATtcagtctgcgtataacaaaaatttaaaatactgg a" /listShort="S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="upshifts" S_feature 1975746..1975926 /Source="Nicolas_S_feature" /locus_tag="new_2306333_2306513" /HighExp="Heat, HiTm, LoTm, C90, M9-stat, HiOs, SMM, UNK1, MG 25, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigWXY" /TUshortPSig="0.999, 0.995, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S826" CDS 1975927..1977075 /gene="ugtP" /locus_tag="BSU_21920" /old_locus_tag="BSU21920" /EC_number="2.4.1.315" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11344159, 17209021, 17662947, 9720862, 18820022, 22362028, 22931116, 27684739" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344159, 17209021, 17662947, 9720862, 18820022, 22362028, 22931116, 27684739; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-glucose diacylglyceroltransferase" /protein_id="NP_390075.1" /db_xref="EnsemblGenomes-Gn:BSU21920" /db_xref="EnsemblGenomes-Tr:CAB14110" /db_xref="GOA:P54166" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR009695" /db_xref="InterPro:IPR023589" /db_xref="SubtiList:BG11611" /db_xref="UniProtKB/Swiss-Prot:P54166" /translation="MNTNKRVLILTANYGNGHVQVAKTLYEQCVRLGFQHVTVSNLYQ ESNPIVSEVTQYLYLKSFSIGKQFYRLFYYGVDKIYNKRKFNIYFKMGNKRLGELVDE HQPDIIINTFPMIVVPEYRRRTGRVIPTFNVMTDFCLHKIWVHENVDKYYVATDYVKE KLLEIGTHPSNVKITGIPIRPQFEESMPVGPIYKKYNLSPNKKVLLIMAGAHGVLKNV KELCENLVKDDQVQVVVVCGKNTALKESLSALEAENGDKLKVLGYVERIDELFRITDC MITKPGGITLTEATAIGVPVILYKPVPGQEKENANFFEDRGAAIVVNRHEEILESVTS LLADEDTLHRMKKNIKDLHLANSSEVILEDILKESEMMTAKQKAKVLS*" /label="ugtP CDS" gene 1975927..1977075 /gene="ugtP" /locus_tag="BSU_21920" /old_locus_tag="BSU21920" /label="ugtP gene" S_feature complement(1976096..1977125) /Source="Nicolas_S_feature" /locus_tag="new_2306683_2307712_c" /HighExp="S8, S7, S6, C30, Lbstat, T0.30H, C90, BT, G135, Fru" /AntisenseName="ugtP" /AntisenseCor="-0.328222465122327" /AntisenseRegPval="-7.4" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S827" downshifts 1977071 /Source="Nicolas_upshifts" /id="D1146" /incds=0 /nref=77 /ntot=240 /MaxReadThrough="4.0787" /MaxDrop="4.20549" /score="21.6989702" /energy="-12.1" /TU="U1715,U1717" /idTUdmin="U1716" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1977107..1977126) /Source="Nicolas_upshift_promotors" /id="U1718" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1392 /SigmaFactorBS="cttatttttcaaaagaagggcaagttccataaaaaaATGTAA CCGcttttattgatggcTGAATATAAATAAAAAGAGCacacgattttcgtatgctctc a" /listShort="S827" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1977125) /Source="Nicolas_upshifts" /id="U1718" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1392 /SigmaFactorBS="cttatttttcaaaagaagggcaagttccataaaaaaATGTAA CCGcttttattgatggcTGAATATAAATAAAAAGAGCacacgattttcgtatgctctc a" /listShort="S827" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1977141..1977149) /Source="Nicolas_upshift_promotors" /id="U1718" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1392 /SigmaFactorBS="cttatttttcaaaagaagggcaagttccataaaaaaATGTAA CCGcttttattgatggcTGAATATAAATAAAAAGAGCacacgattttcgtatgctctc a" /listShort="S827" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1977156..1977302 /locus_tag="BSU_21925" /old_locus_tag="BSU21925" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513973.1" /translation="MELALLLKNKPFRNLTGAPRWCIVEPSFNNESKLDDDKIFFSTW VLQY*" /label="hypothetical protein CDS" gene 1977156..1977302 /locus_tag="BSU_21925" /old_locus_tag="BSU21925" /label="gene" promotor_-35 1977195..1977202 /Source="Nicolas_upshift_promotors" /id="U1719" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.829170829170829" /psig="0.999000999001" /xcortree=3102 /SigmaFactorBS="ccttcttttgaaaaataagccgtttcgcAACTTGACgggtgc tcccagaTGGTGTATAGTTGAACCATCatttaacaatgaatcaaagttagatgatgac a" /listShort="S828, cspD, S829, ypzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1977216..1977235 /Source="Nicolas_upshift_promotors" /id="U1719" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.829170829170829" /psig="0.999000999001" /xcortree=3102 /SigmaFactorBS="ccttcttttgaaaaataagccgtttcgcAACTTGACgggtgc tcccagaTGGTGTATAGTTGAACCATCatttaacaatgaatcaaagttagatgatgac a" /listShort="S828, cspD, S829, ypzA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1977227..1977317 /Source="Nicolas_S_feature" /locus_tag="new_2307814_2307904" /HighExp="C90, T5.0H, T3.30H, T3.0H, HiOs, Salt, LoTm, T-3.40H, S3, T-0.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigA, SigA, SigWXY" /TUlongPSig="0.999, 0.995, 1" /label="S828" upshifts 1977227 /Source="Nicolas_upshifts" /id="U1719" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.829170829170829" /psig="0.999000999001" /xcortree=3102 /SigmaFactorBS="ccttcttttgaaaaataagccgtttcgcAACTTGACgggtgc tcccagaTGGTGTATAGTTGAACCATCatttaacaatgaatcaaagttagatgatgac a" /listShort="S828, cspD, S829, ypzA" /GFF_Attribute="listLong" /label="upshifts" CDS 1977318..1977518 /gene="cspD" /locus_tag="BSU_21930" /old_locus_tag="BSU21930" /function="16.13: Shape" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9920884, 16352840" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9920884, 16352840; Product type f: factor" /codon_start=1 /transl_table=11 /product="cold-shock protein, molecular chaperone, RNA-helicase co-factor" /protein_id="NP_390076.1" /db_xref="EnsemblGenomes-Gn:BSU21930" /db_xref="EnsemblGenomes-Tr:CAB14111" /db_xref="GOA:P51777" /db_xref="InterPro:IPR002059" /db_xref="InterPro:IPR011129" /db_xref="InterPro:IPR012156" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR019844" /db_xref="SubtiList:BG11531" /db_xref="UniProtKB/Swiss-Prot:P51777" /translation="MQNGKVKWFNNEKGFGFIEVEGGDDVFVHFTAIEGDGYKSLEEG QEVSFEIVEGNRGPQASNVVKL*" /label="cspD CDS" gene 1977318..1977518 /gene="cspD" /locus_tag="BSU_21930" /old_locus_tag="BSU21930" /label="cspD gene" downshifts 1977533 /Source="Nicolas_upshifts" /id="D1147" /incds=0 /nref=257 /ntot=269 /MaxReadThrough="5.19931" /MaxDrop="8.09346" /score="9.24662311" /energy="-15.6" /TU="U1719" /idTUdmin="U1715" /TUdmin=308 /isTUend="FALSE" /label="downshifts" CDS complement(1977570..1977752) /gene="degR" /locus_tag="BSU_21940" /old_locus_tag="BSU21940" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16625836, 19251843, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16625836, 19251843, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="activator of degradative enzymes (aprE, nprE, sacB) production or activity" /protein_id="NP_390077.1" /db_xref="EnsemblGenomes-Gn:BSU21940" /db_xref="EnsemblGenomes-Tr:CAB14112" /db_xref="GOA:P68731" /db_xref="SubtiList:BG10699" /db_xref="UniProtKB/Swiss-Prot:P68731" /translation="MDDKDLKLILHKTFIEIYSDLEELADIAKKGKPSMEKYVEEIEQ RCKQNILAIEIQMKIK*" /label="degR CDS" gene complement(1977570..1977752) /gene="degR" /locus_tag="BSU_21940" /old_locus_tag="BSU21940" /label="degR gene" S_feature 1977578..1977883 /Source="Nicolas_S_feature" /locus_tag="new_2308165_2308470" /HighExp="Cold, LoTm, T4.0H, T3.30H, Pyr, T5.0H, Gly, T3.0H, S0, C30" /AntisenseName="degR" /AntisenseCor="-0.145220711637392" /AntisenseRegPval="-1.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigA, SigA, SigWXY" /TUlongPSig="0.999, 0.995, 1" /label="S829" downshifts complement(1977587) /Source="Nicolas_upshifts" /id="D1148" /incds=0 /nref=133 /ntot=216 /MaxReadThrough="3.75638" /MaxDrop="5.32427" /score="16.1392275" /energy="-7.3" /TU="U1720" /idTUdmin="U1720" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1977813..1977831) /Source="Nicolas_upshift_promotors" /id="U1720" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=2841 /SigmaFactorBS="acaaaaaacacctccgccattattttgcagagtttttttgaa atttatgtaccaaaatAGAAAAGaaaataaaaataaGCCGATATAACTATTGAACcag a" /listShort="degR" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1977845..1977851) /Source="Nicolas_upshift_promotors" /id="U1720" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=2841 /SigmaFactorBS="acaaaaaacacctccgccattattttgcagagtttttttgaa atttatgtaccaaaatAGAAAAGaaaataaaaataaGCCGATATAACTATTGAACcag a" /listShort="degR" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1977849) /Source="Nicolas_upshifts" /id="U1720" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=2841 /SigmaFactorBS="acaaaaaacacctccgccattattttgcagagtttttttgaa atttatgtaccaaaatAGAAAAGaaaataaaaataaGCCGATATAACTATTGAACcag a" /listShort="degR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1977859..1977865 /Source="Nicolas_upshift_promotors" /id="U1721" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=913 /SigmaFactorBS="tatcggcttatttttattttcttttctattttggTACATAAa tttcaaaaaaactCTGCAAAATAATggcggaggtgttttttgtgacttcagaatttca t" /listShort="ypzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1977880..1977891 /Source="Nicolas_upshift_promotors" /id="U1721" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=913 /SigmaFactorBS="tatcggcttatttttattttcttttctattttggTACATAAa tttcaaaaaaactCTGCAAAATAATggcggaggtgttttttgtgacttcagaatttca t" /listShort="ypzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1977885 /Source="Nicolas_upshifts" /id="U1721" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=913 /SigmaFactorBS="tatcggcttatttttattttcttttctattttggTACATAAa tttcaaaaaaactCTGCAAAATAATggcggaggtgttttttgtgacttcagaatttca t" /listShort="ypzA" /GFF_Attribute="listLong" /label="upshifts" CDS 1977908..1978177 /gene="ypzA" /locus_tag="BSU_21950" /old_locus_tag="BSU21950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12562816, 22882546; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_390078.1" /db_xref="EnsemblGenomes-Gn:BSU21950" /db_xref="EnsemblGenomes-Tr:CAB14113" /db_xref="InterPro:IPR020314" /db_xref="SubtiList:BG13764" /db_xref="UniProtKB/Swiss-Prot:O32007" /translation="MTSEFHNEDQTGFTDKRQLELAVETAQKTTGAATRGQSKTLVDS AYQAIEDARELSQSEELAALDDPEFVKQQQQLLDDSEHQLDEFKE*" /label="ypzA CDS" gene 1977908..1978177 /gene="ypzA" /locus_tag="BSU_21950" /old_locus_tag="BSU21950" /label="ypzA gene" downshifts 1978032 /Source="Nicolas_upshifts" /id="D1149" /incds=1 /nref=3 /ntot=82 /MaxReadThrough="6.79633" /MaxDrop="4.11501" /score="22.0113838" /energy="-7.3" /TU="U1719,U1721" /idTUdmin="U1719" /TUdmin="-117" /isTUend="FALSE" /label="downshifts" downshifts 1978160 /Source="Nicolas_upshifts" /id="D1150" /incds=0 /nref=18 /ntot=94 /MaxReadThrough="2.31821" /MaxDrop="6.65627" /score="22.0113838" /energy="-7.3" /TU="NA" /idTUdmin="U1719" /TUdmin=11 /isTUend="TRUE" /label="downshifts" CDS complement(1978205..1978387) /gene="ypeQ" /locus_tag="BSU_21960" /old_locus_tag="BSU21960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12562816" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390079.1" /db_xref="EnsemblGenomes-Gn:BSU21960" /db_xref="EnsemblGenomes-Tr:CAB14114" /db_xref="InterPro:IPR019718" /db_xref="SubtiList:BG11610" /db_xref="UniProtKB/Swiss-Prot:P54165" /translation="MDKKMIFKELTELHDEYCKDCFIKKQFRKEFGKTYAHSFCINKC TVGEKLKQYGDVLTNH*" /label="ypeQ CDS" gene complement(1978205..1978387) /gene="ypeQ" /locus_tag="BSU_21960" /old_locus_tag="BSU21960" /label="ypeQ gene" downshifts complement(1978225) /Source="Nicolas_upshifts" /id="D1151" /incds=0 /nref=5 /ntot=102 /MaxReadThrough="2.77117" /MaxDrop="4.29218" /score="16.1392275" /energy="-7.3" /TU="NA" /idTUdmin="U1723" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1978380..1979060) /gene="ypeP" /locus_tag="BSU_21970" /old_locus_tag="BSU21970" /EC_number="3.1.-.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12562816, 17905985, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562816, 17905985, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease" /protein_id="NP_390080.2" /db_xref="EnsemblGenomes-Gn:BSU21970" /db_xref="EnsemblGenomes-Tr:CAB14115" /db_xref="GOA:P54164" /db_xref="InterPro:IPR002156" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG11609" /db_xref="UniProtKB/Swiss-Prot:P54164" /translation="MKLRPHLKIEAKGTGSVSFFSEDWLTAQQARTFARELGRFPYMK ELEFEDEKGGSWTLKELEKLTEELAQEPDDITVYFDGSFDKESELAGLGIVIYYSLGG TRHRLRKNKSFRLKTNNEAEYAALYEAIREVRELGASRNSITIKGDSLVVLNQLDGSW PCYDPSHNEWLDKIEALLESLKLTPTYETIQRKDNQEADGLAKKILSHQFVESHTKLD RNGDDDIG*" /label="ypeP CDS" gene complement(1978380..1979060) /gene="ypeP" /locus_tag="BSU_21970" /old_locus_tag="BSU21970" /label="ypeP gene" S_feature complement(1979061..1979198) /Source="Nicolas_S_feature" /locus_tag="new_2309648_2309785_c" /HighExp="S5, S4, S6, S8, S7, S3, T5.0H, T4.0H, BT, Pyr" /AntisenseName="ypdP" /AntisenseCor="-0.65324924042743404" /AntisenseRegPval="-33.4" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH" /TUshortPSig="0.92, 0.564" /TUlongSig="NA" /TUlongPSig="NA" /label="S830" promotor_-35 1979077..1979082 /Source="Nicolas_upshift_promotors" /id="U1722" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig="0.999000999001" /xcortree=2280 /SigmaFactorBS="caaatgcggtctgagcttcattacaatcaccttaccaTTCAT TagttgccgggctTATGCTATAATCAAACCAATcttaccccggaaaggaagctttttc a" /listShort="ypdP, ypdQ, sspL, S832" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1979095..1979114 /Source="Nicolas_upshift_promotors" /id="U1722" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig="0.999000999001" /xcortree=2280 /SigmaFactorBS="caaatgcggtctgagcttcattacaatcaccttaccaTTCAT TagttgccgggctTATGCTATAATCAAACCAATcttaccccggaaaggaagctttttc a" /listShort="ypdP, ypdQ, sspL, S832" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1979100 /Source="Nicolas_upshifts" /id="U1722" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig="0.999000999001" /xcortree=2280 /SigmaFactorBS="caaatgcggtctgagcttcattacaatcaccttaccaTTCAT TagttgccgggctTATGCTATAATCAAACCAATcttaccccggaaaggaagctttttc a" /listShort="ypdP, ypdQ, sspL, S832" /GFF_Attribute="listLong" /label="upshifts" CDS 1979143..1979832 /gene="queP" /locus_tag="BSU_21980" /old_locus_tag="BSU21980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 28208705; Product type t : transporter" /codon_start=1 /transl_table=11 /product="preQ0 transporter (promiscuous)" /protein_id="NP_390081.1" /db_xref="EnsemblGenomes-Gn:BSU21980" /db_xref="EnsemblGenomes-Tr:CAB14116" /db_xref="GOA:P54163" /db_xref="InterPro:IPR003744" /db_xref="SubtiList:BG11607" /db_xref="UniProtKB/Swiss-Prot:P54163" /translation="MFNNSFWIFFAIIHFIIVLLFYKGFGKMGLFVWIGFATVCANLQ VVKTVELFGLTATLGNVMYGTIFFATDVLNEKYGPAEARKAVWLGFSTLLTLTFVMQG VLLFEPASSDISQTALETIFGFLPRVALGSLLAFIFSQTLDVYVYSAIRRIFPSDRLL WLRNGGSTAVSQLFDTFIFTAVAFLGIYPADVWLHIFISTYLIKFAVSLISLPYAYAA KKMIPNDERSS*" /label="queP CDS" gene 1979143..1979832 /gene="queP" /locus_tag="BSU_21980" /old_locus_tag="BSU21980" /label="queP gene" promotor_-35 complement(1979196..1979212) /Source="Nicolas_upshift_promotors" /id="U1723" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.92007992007992" /xcortree=644 /SigmaFactorBS="gactgtcgcaaaaccgatccaaacaaacagtcccattttgcc aaatcCTTTATAAAATAAAAGAacAatgataaaatgaatgatcgcaaaaaagatccaa a" /listShort="S830, ypeP, ypeQ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1979199) /Source="Nicolas_upshifts" /id="U1723" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.92007992007992" /xcortree=644 /SigmaFactorBS="gactgtcgcaaaaccgatccaaacaaacagtcccattttgcc aaatcCTTTATAAAATAAAAGAacAatgataaaatgaatgatcgcaaaaaagatccaa a" /listShort="S830, ypeP, ypeQ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1979200..1979589) /Source="Nicolas_S_feature" /locus_tag="new_2309787_2310176_c" /HighExp="S5, S4, S6, S7, S8, T5.0H, S3, T4.0H, BT, M9-stat" /AntisenseName="ypdP" /AntisenseCor="-0.645700204826543" /AntisenseRegPval="-32.4" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig="0.564" /TUlongSig="NA" /TUlongPSig="NA" /label="S831" promotor_-10 complement(1979570..1979589) /Source="Nicolas_upshift_promotors" /id="U1724" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.564435564435564" /psig="0.564435564435564" /xcortree=1217 /SigmaFactorBS="ctgtactgccgccgtttctgagccataaaagccgatcaGAAG GAAATatccttctaatTGCCGAATATACATAAACATccagcgtttggctgaagataaa g" /listShort="S831, S830, ypeP, ypeQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1979587) /Source="Nicolas_upshifts" /id="U1724" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.564435564435564" /psig="0.564435564435564" /xcortree=1217 /SigmaFactorBS="ctgtactgccgccgtttctgagccataaaagccgatcaGAAG GAAATatccttctaatTGCCGAATATACATAAACATccagcgtttggctgaagataaa g" /listShort="S831, S830, ypeP, ypeQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1979601..1979609) /Source="Nicolas_upshift_promotors" /id="U1724" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.564435564435564" /psig="0.564435564435564" /xcortree=1217 /SigmaFactorBS="ctgtactgccgccgtttctgagccataaaagccgatcaGAAG GAAATatccttctaatTGCCGAATATACATAAACATccagcgtttggctgaagataaa g" /listShort="S831, S830, ypeP, ypeQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1979832..1980230 /gene="ypdQ" /locus_tag="BSU_21990" /old_locus_tag="BSU21990" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9888800, 10094689, 15115438, 17905985; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative RNA binding protein (no RNase H activity)" /protein_id="NP_390082.1" /db_xref="EnsemblGenomes-Gn:BSU21990" /db_xref="EnsemblGenomes-Tr:CAB14117" /db_xref="GOA:P54162" /db_xref="InterPro:IPR002156" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG11608" /db_xref="UniProtKB/Swiss-Prot:P54162" /translation="MPTEIYVDGASAGNPGPSGIGIFIKHEGKAESFSIPIGVHTNQE AEFLALIEGMKLCATRGYQSVSFRTDSDIVERATELEMVKNITFQPFVEEIIRLKAAF PLFFIKWIPGKQNQKADLLAKEAIRLNEKN*" /label="ypdQ CDS" gene 1979832..1980230 /gene="ypdQ" /locus_tag="BSU_21990" /old_locus_tag="BSU21990" /label="ypdQ gene" promotor_-35 1980223..1980229 /Source="Nicolas_upshift_promotors" /id="U1725" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=921 /SigmaFactorBS="gcaaaagaagcgattcggctgaatgaaaAGAATTAaatcttg atcattgGTTCATCCTAATggcgaggtgaactaacatgaaaaagaaagataaaggccg g" /listShort="sspL, S832" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1980244..1980255 /Source="Nicolas_upshift_promotors" /id="U1725" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=921 /SigmaFactorBS="gcaaaagaagcgattcggctgaatgaaaAGAATTAaatcttg atcattgGTTCATCCTAATggcgaggtgaactaacatgaaaaagaaagataaaggccg g" /listShort="sspL, S832" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1980255 /Source="Nicolas_upshifts" /id="U1725" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=921 /SigmaFactorBS="gcaaaagaagcgattcggctgaatgaaaAGAATTAaatcttg atcattgGTTCATCCTAATggcgaggtgaactaacatgaaaaagaaagataaaggccg g" /listShort="sspL, S832" /GFF_Attribute="listLong" /label="upshifts" CDS 1980272..1980400 /gene="sspL" /locus_tag="BSU_22000" /old_locus_tag="BSU22000" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10333516" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10333516; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="YP_054584.1" /db_xref="EnsemblGenomes-Gn:BSU22000" /db_xref="EnsemblGenomes-Tr:CAE01458" /db_xref="GOA:Q7WY66" /db_xref="InterPro:IPR017526" /db_xref="SubtiList:BG14176" /db_xref="UniProtKB/Swiss-Prot:Q7WY66" /translation="MKKKDKGRLTGGVTPQGDLEGNTHNDPKTELEERAKKSNTKR*" /label="sspL CDS" gene 1980272..1980400 /gene="sspL" /locus_tag="BSU_22000" /old_locus_tag="BSU22000" /label="sspL gene" S_feature 1980401..1981381 /Source="Nicolas_S_feature" /locus_tag="new_2310988_2311968" /HighExp="S8, S7, S5, S6, S4, C30, nit, ferm, Pyr, S3" /AntisenseName="exoA" /AntisenseCor="-0.365099613028674" /AntisenseRegPval="-9.1999999999999993" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigA" /TUshortPSig="0.999, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S832" CDS complement(1980408..1981298) /gene="exnP" /locus_tag="BSU_22010" /old_locus_tag="BSU22010" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:16045613, 17038322, 17905985, 27435445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16045613, 17038322, 17905985, 27435445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5'3'-exonuclease" /protein_id="NP_390083.1" /db_xref="EnsemblGenomes-Gn:BSU22010" /db_xref="EnsemblGenomes-Tr:CAB14118" /db_xref="GOA:P54161" /db_xref="InterPro:IPR002421" /db_xref="InterPro:IPR008918" /db_xref="InterPro:IPR020045" /db_xref="InterPro:IPR020046" /db_xref="InterPro:IPR029060" /db_xref="InterPro:IPR036279" /db_xref="SubtiList:BG11606" /db_xref="UniProtKB/Swiss-Prot:P54161" /translation="MNNNKLLLVDGMALLFRAFFATAVHRNFMINDSGVPTNGVNGFL KHLITAVETFQPTHVVCCWDMGSKTYRNDLFQDYKANRSAPPVELIPQFDLAKEAAAE LGIMNIGFAGYEADDCIGTLADLFANEADITVVTGDRDLLQLLTDKVSVALLQKGIGN YKVYTKETFYEETGVMPKALIDIKALMGDSSDNYPGVKGIGEKTAYKLIREYETIDRL LENLSLLPKGQQGKIQQGLSDLEMSRKLAEIHCSVPLACTLKDALFTLQMEQAADMLR RHQIKGIERMLEKLNAREIV*" /label="exnP CDS" gene complement(1980408..1981298) /gene="exnP" /locus_tag="BSU_22010" /old_locus_tag="BSU22010" /label="exnP gene" downshifts complement(1980445) /Source="Nicolas_upshifts" /id="D1152" /incds=0 /nref=10 /ntot=174 /MaxReadThrough="2.94148" /MaxDrop="4.49836" /score="3.60870815" /energy="-15.6" /TU="U1726" /idTUdmin="U1726" /TUdmin="-284" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1981320..1981339) /Source="Nicolas_upshift_promotors" /id="U1726" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2164 /SigmaFactorBS="acagtatctctaattaaagagatactgtttTTTATTTttggg ctgcttTATGATAAAATAGAAGGAATgaaagaaaagggagttatttgatgaataataa t" /listShort="exoA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1981327) /Source="Nicolas_upshifts" /id="U1726" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2164 /SigmaFactorBS="acagtatctctaattaaagagatactgtttTTTATTTttggg ctgcttTATGATAAAATAGAAGGAATgaaagaaaagggagttatttgatgaataataa t" /listShort="exoA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1981351..1981357) /Source="Nicolas_upshift_promotors" /id="U1726" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2164 /SigmaFactorBS="acagtatctctaattaaagagatactgtttTTTATTTttggg ctgcttTATGATAAAATAGAAGGAATgaaagaaaagggagttatttgatgaataataa t" /listShort="exoA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1981355 /Source="Nicolas_upshifts" /id="D1153" /incds=0 /nref=4 /ntot=32 /MaxReadThrough="0.83304" /MaxDrop="4.41573" /score="0.126370352" /energy="-15" /TU="NA" /idTUdmin="U1725" /TUdmin=16 /isTUend="TRUE" /label="downshifts" CDS complement(1981399..1981545) /gene="ypzF" /locus_tag="BSU_22019" /old_locus_tag="BSU22019" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097753.1" /db_xref="EnsemblGenomes-Gn:BSU22019" /db_xref="EnsemblGenomes-Tr:CAX52652" /db_xref="UniProtKB/Swiss-Prot:C0H443" /translation="MLGRTKLGNRNAQANNNAKKKNGFQTHFDSYAGREAEKLIASNK RHND*" /label="ypzF CDS" gene complement(1981399..1981545) /gene="ypzF" /locus_tag="BSU_22019" /old_locus_tag="BSU22019" /label="ypzF gene" downshifts complement(1981415) /Source="Nicolas_upshifts" /id="D1154" /incds=0 /nref=253 /ntot=272 /MaxReadThrough="0.89691" /MaxDrop="8.47168" /score="25.632979" /energy="-12" /TU="NA" /idTUdmin="U1727" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(1981569) /Source="Nicolas_upshifts" /id="U1727" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=846 /SigmaFactorBS="ccgcatgtaagctggatgatcctgtcgCGAGTGAacctcctg ccggaaGCATATACTATAtgcatccgacgtaaggggggattcatgttgggcagaacaa a" /listShort="ypzF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1981570..1981581) /Source="Nicolas_upshift_promotors" /id="U1727" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=846 /SigmaFactorBS="ccgcatgtaagctggatgatcctgtcgCGAGTGAacctcctg ccggaaGCATATACTATAtgcatccgacgtaaggggggattcatgttgggcagaacaa a" /listShort="ypzF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1981596..1981602) /Source="Nicolas_upshift_promotors" /id="U1727" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=846 /SigmaFactorBS="ccgcatgtaagctggatgatcctgtcgCGAGTGAacctcctg ccggaaGCATATACTATAtgcatccgacgtaaggggggattcatgttgggcagaacaa a" /listShort="ypzF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1981620..1981877) /gene="ypbS" /locus_tag="BSU_22020" /old_locus_tag="BSU22020" /experiment="publication(s) with functional evidences, PMID:20709900, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20709900, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="spore associated protein" /protein_id="NP_390084.1" /db_xref="EnsemblGenomes-Gn:BSU22020" /db_xref="EnsemblGenomes-Tr:CAB14119" /db_xref="InterPro:IPR019688" /db_xref="SubtiList:BG11605" /db_xref="UniProtKB/Swiss-Prot:P54160" /translation="MSEVHKAISAHSSKQHEHIKAFMRLENMRELAIEEAVAKCRNDE PYTTDAINEITEQMNQLAKKGIVPTRRLVSKEMVREYVSRM*" /label="ypbS CDS" gene complement(1981620..1981877) /gene="ypbS" /locus_tag="BSU_22020" /old_locus_tag="BSU22020" /label="ypbS gene" promotor_-10 complement(1981897..1981916) /Source="Nicolas_upshift_promotors" /id="U1728" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.678321678321678" /psig=1 /xcortree=3060 /SigmaFactorBS="gaaaaattcagacaatacaataaaaatgtaaaattcaGTTGG CTTgtatttcaagtCATGATAGACTAAATAGAAAaaagcgagatgaacgattaatgtc a" /listShort="ypbS, ypzF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1981912) /Source="Nicolas_upshifts" /id="U1728" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.678321678321678" /psig=1 /xcortree=3060 /SigmaFactorBS="gaaaaattcagacaatacaataaaaatgtaaaattcaGTTGG CTTgtatttcaagtCATGATAGACTAAATAGAAAaaagcgagatgaacgattaatgtc a" /listShort="ypbS, ypzF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1981928..1981935) /Source="Nicolas_upshift_promotors" /id="U1728" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.678321678321678" /psig=1 /xcortree=3060 /SigmaFactorBS="gaaaaattcagacaatacaataaaaatgtaaaattcaGTTGG CTTgtatttcaagtCATGATAGACTAAATAGAAAaaagcgagatgaacgattaatgtc a" /listShort="ypbS, ypzF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1981942..1985523) /gene="dynA" /locus_tag="BSU_22030" /old_locus_tag="BSU22030" /EC_number="3.6.5.5" /experiment="publication(s) with functional evidences, PMID:21205012, 23388828, 23249255, 26842743, 26530236" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21205012, 23388828, 23249255, 26842743, 26530236; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dynamin GTPase" /protein_id="NP_390085.1" /db_xref="EnsemblGenomes-Gn:BSU22030" /db_xref="EnsemblGenomes-Tr:CAB14120" /db_xref="GOA:P54159" /db_xref="InterPro:IPR022812" /db_xref="InterPro:IPR027094" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11604" /db_xref="UniProtKB/Swiss-Prot:P54159" /translation="MTDQNRKELLHKTGELYKQFIENQDEQRAAKLAAVMKKAADEEV YIAFTGHYSAGKSSLLNCLLMENILPTSPIPTSANLVVIRNGEKRVRLHTTDGACAEL EGTYQKDKVQQYCKDGEQIESVEIFDRYTEIDSGVAYIDTPGIDSTDDAHFLSAASIL HQADALFYVVHYNHVHAEENVKFLRSIKESIPNVYFIVNQIDRHDETETKFGDYQAQV EEMLCNEGISREALYFTSVTEPDHPFNQMGALREELSRIEQQSKSNMQALTEQKVRNL LKEHTEMLKKDETGAPSFAEQLNIHTGLVQSLRDQLDEAEKQMTEAEKRMQEEINRIL KNANLTPFEMRELAAAFLESQEPSFKTGFFFSKAKTAQERDKRRNAFFSDVAKRTEAE ADWHMIDTLHKLAKVFDVYTAESEKLIQAYRTPLDISIIEHAVKHGAAFSSEYVLQYT KDLAELIRKEAKREAADIIKVLSAMVKERVSKDVQTINDRLVQESEKLVFLQEQARLE NNAREKTDRLWAIWEEESACPMHIDTEWFKSKKTRVAAPEQKQGRSQLTAQPMPKSEI KMEQEMPLQDQIKRFYTLSDILGECSMLLKQTSAFRERVKRLEERKFTLALFGGFSSG KSSFANALVGERVLPSSPTPTTATINKITKPINGNLNKTANVVFKTEDDLTAEILQLT GIPKEPAGRSFTEKWEKAVKKNRLQEEHVKLISNFLLAYEKYQQYIQEQKKLTIPLSE LKPYVAEETTACAVKEVTVYYTCPLTEKGITIVDTPGASSMNKRHTELAFQYIKDADA FFYMTYYQHSFSKGDRSFLRKLGLVKESLSMDKMFFIINAADLAKDKTELETVTDYVS AELVKEGVYEPQLFTVSSKEELVGKPESFYNQFSKVRKHLDRFIEVDVKKASAAQLSS EADKLCETVFQLHQSQHQSREEKEAQKQCLMLSFERTAADIEKRRNSKTIIEKVKKDT REQLYHIAQRLSYFANDLLKSAFHPGLQNGDWKKNVSKAMTTALHEYLFEYIQEIKTL DVRMSGFIERHINEEWLDHFQKTLNEDGYFSVYAGDQHSNGIQLKEVEPEIEERAFEQ ELKEIKSPKQFFEQKGKATFIEAVRMKLTKITEAWIKNEEESLISHYTAHLRRLQEDM GEKAIAQITDQKETYLRGYAEGEHAKEIEMAYQACISWKNSDNTIKM*" /label="dynA CDS" gene complement(1981942..1985523) /gene="dynA" /locus_tag="BSU_22030" /old_locus_tag="BSU22030" /label="dynA gene" S_feature complement(1985524..1985595) /Source="Nicolas_S_feature" /locus_tag="new_2316111_2316182_c" /HighExp="LBGstat, T1.30H, T1.0H, BMM, T2.30H, M9-stat, MG 150, T0.30H, T2.0H, GM-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S833" misc_feature complement(1985585..1985604) /Source="Nicolas_upshift_promotors" /id="U1729" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.61038961038961" /psig="0.987012987012987" /xcortree=2239 /SigmaFactorBS="gctgccgtaatggcggcttttttctattctcctaaagaaatt tggtttattCTTGTGTAAAATGAAAAGGGaatgaattcagatctttcgaaaaaggttc a" /listShort="S833, ypbR" /listLong="ypbS, ypzF" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1985595) /Source="Nicolas_upshifts" /id="U1729" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.61038961038961" /psig="0.987012987012987" /xcortree=2239 /SigmaFactorBS="gctgccgtaatggcggcttttttctattctcctaaagaaatt tggtttattCTTGTGTAAAATGAAAAGGGaatgaattcagatctttcgaaaaaggttc a" /listShort="S833, ypbR" /listLong="ypbS, ypzF" /label="upshifts" S_feature complement(1985640..1985837) /Source="Nicolas_S_feature" /locus_tag="new_2316227_2316424_c" /HighExp="HiOs, B60, GM 25, S7, GM 15, B36, S5, S8, GM 5, GM 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.24118200000000001" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S834" downshifts complement(1985683) /Source="Nicolas_upshifts" /id="D1155" /incds=0 /nref=1 /ntot=38 /MaxReadThrough="3.11615" /MaxDrop="3.46525" /score="27.1937922" /energy="-9.7" /TU="U1730" /idTUdmin="U1730" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(1985699..1985788) /gene="fbpC" /locus_tag="BSU_22036" /old_locus_tag="BSU22036" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18697947, 22389480, 22427629" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18697947, 22389480, 22427629; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of iron homeostasis" /protein_id="YP_009513974.1" /db_xref="EnsemblGenomes-Gn:BSU22036" /db_xref="EnsemblGenomes-Tr:CCQ48599" /db_xref="UniProtKB/TrEMBL:L8ECR0" /translation="MTMLFLLGAVCTYSVLIGFVLKGISNKSV*" /label="fbpC CDS" gene complement(1985699..1985788) /gene="fbpC" /locus_tag="BSU_22036" /old_locus_tag="BSU22036" /label="fbpC gene" promotor_-10 complement(1985816..1985835) /Source="Nicolas_upshift_promotors" /id="U1730" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=2098 /SigmaFactorBS="gcagaagacaaagcattacaggaatacagcgtaaaatagcGA TTGAAAatcattctcaaccaTGTTAAAATGGGTTTGAAAAagattctcaatcaggatg g" /listShort="S834" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1985837) /Source="Nicolas_upshifts" /id="U1730" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=2098 /SigmaFactorBS="gcagaagacaaagcattacaggaatacagcgtaaaatagcGA TTGAAAatcattctcaaccaTGTTAAAATGGGTTTGAAAAagattctcaatcaggatg g" /listShort="S834" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1985850..1985857) /Source="Nicolas_upshift_promotors" /id="U1730" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=2098 /SigmaFactorBS="gcagaagacaaagcattacaggaatacagcgtaaaatagcGA TTGAAAatcattctcaaccaTGTTAAAATGGGTTTGAAAAagattctcaatcaggatg g" /listShort="S834" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1985859..1986365) /gene="bpsB" /locus_tag="BSU_22040" /old_locus_tag="BSU22040" /EC_number="2.1.1.-" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16850406, 7726551, 8396117, 19465653" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16850406, 7726551, 8396117, 19465653; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="alkylpyrone methyltransferase (polyketide synthesis)" /protein_id="NP_390086.1" /db_xref="EnsemblGenomes-Gn:BSU22040" /db_xref="EnsemblGenomes-Tr:CAB14121" /db_xref="GOA:P54158" /db_xref="InterPro:IPR007269" /db_xref="SubtiList:BG11603" /db_xref="UniProtKB/Swiss-Prot:P54158" /translation="MFWLLIAILIVQRAAEMAVARQNEQKVKKQGAIEFGESHYPYII TMHILFFLSLIAEVLLMNKQPSSWWLGIAAVILSVQIVRYWALCSLGAYWNTKILVVP GVELVKKGPYKWMKHPNYAVVILEILLIPLLYQAYVTMCLFSIFNAVLLSVRIRAEDK ALQEYSVK*" /label="bpsB CDS" gene complement(1985859..1986365) /gene="bpsB" /locus_tag="BSU_22040" /old_locus_tag="BSU22040" /label="bpsB gene" CDS complement(1986369..1987466) /gene="bpsA" /locus_tag="BSU_22050" /old_locus_tag="BSU22050" /EC_number="2.3.1.-" /function="15.10: Adaptations to atypical conditions" /experiment="publication(s) with functional evidences, PMID:19465653" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19465653; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous alkylpyrone synthase BpsA (polyketide synthesis)" /protein_id="NP_390087.1" /db_xref="EnsemblGenomes-Gn:BSU22050" /db_xref="EnsemblGenomes-Tr:CAB14122" /db_xref="GOA:P54157" /db_xref="InterPro:IPR001099" /db_xref="InterPro:IPR011141" /db_xref="InterPro:IPR012328" /db_xref="InterPro:IPR016039" /db_xref="InterPro:IPR018088" /db_xref="SubtiList:BG11523" /db_xref="UniProtKB/Swiss-Prot:P54157" /translation="MAFILSIGTSLPAYNVNQEKAAEFARYMFQHSFKDIDRLLSSFK NGQIHSRQFVKPIEWYKEGHSFEEKNQIYIEETLKHSRAAVRECLSHPEFFQEAIPYE KVEAVFFVSSTGLSTPSIEARLMNELPFSPYTKRIPIWGLGCAGGASGLARAAEYCKA YPEAFVLVISAELCSLTFQPEDKTKSNLIGTSLFGDGIAAALLCGEKADRRVSKLKLA PKIMDAQSVLMKQSEDVMGWDFTDQGFKVIFSRDIPTLVEKWLKTNVQIFLDKHKLSF HDISVFLAHPGGKKVIDAYIKSLGLSSEKLSSAQSILQKHGNMSSATILYVIKDHLQN GHKKEAERGLIGALGPGFSSELLLFSWEKGA*" /label="bpsA CDS" gene complement(1986369..1987466) /gene="bpsA" /locus_tag="BSU_22050" /old_locus_tag="BSU22050" /label="bpsA gene" promotor_-10 complement(1987484..1987495) /Source="Nicolas_upshift_promotors" /id="U1731" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=901 /SigmaFactorBS="cagtctaactccgccgcggcggagtttttttTGCATATaaaa aagattgttgCGGCACAATGTAtgcaaagaggtgatcgcatggcgtttattttatcca t" /listShort="bcsA, ypbQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1987487) /Source="Nicolas_upshifts" /id="U1731" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=901 /SigmaFactorBS="cagtctaactccgccgcggcggagtttttttTGCATATaaaa aagattgttgCGGCACAATGTAtgcaaagaggtgatcgcatggcgtttattttatcca t" /listShort="bcsA, ypbQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1987510..1987516) /Source="Nicolas_upshift_promotors" /id="U1731" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=901 /SigmaFactorBS="cagtctaactccgccgcggcggagtttttttTGCATATaaaa aagattgttgCGGCACAATGTAtgcaaagaggtgatcgcatggcgtttattttatcca t" /listShort="bcsA, ypbQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1987540..1988856) /gene="pbuX" /locus_tag="BSU_22060" /old_locus_tag="BSU22060" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9098051, 12923093, 15549109, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9098051, 12923093, 15549109, 15849754, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="xanthine permease" /protein_id="NP_390088.1" /db_xref="EnsemblGenomes-Gn:BSU22060" /db_xref="EnsemblGenomes-Tr:CAB14123" /db_xref="GOA:P42086" /db_xref="InterPro:IPR006042" /db_xref="InterPro:IPR006043" /db_xref="InterPro:IPR017588" /db_xref="SubtiList:BG11080" /db_xref="UniProtKB/Swiss-Prot:P42086" /translation="MRNGFGKTLSLGIQHVLAMYAGAIVVPLIVGKAMGLTVEQLTYL VSIDIFMCGVATLLQVWSNRFFGIGLPVVLGCTFTAVSPMIAIGSEYGVSTVYGSIIA SGILVILISFFFGKLVSFFPPVVTGSVVTIIGITLMPVAMNNMAGGEGSADFGDLSNL ALAFTVLSIIVLLYRFTKGFIKSVSILIGILIGTFIAYFMGKVQFDNVSDAAVVQMIQ PFYFGAPSFHAAPIITMSIVAIVSLVESTGVYFALGDLTNRRLTEIDLSKGYRAEGLA VLLGGIFNAFPYTAFSQNVGLVQLTGIKKNAVIVVTGVILMAFGLFPKIAAFTTIIPS AVLGGAMVAMFGMVIAYGIKMLSRIDFAKQENLLIVACSVGLGLGVTVVPDIFKQLPS ALTLLTTNGIVAGSFTAVVLNIVYNVFSKAKKIEQEADLAEQKTAV*" /label="pbuX CDS" gene complement(1987540..1988856) /gene="pbuX" /locus_tag="BSU_22060" /old_locus_tag="BSU22060" /label="pbuX gene" downshifts complement(1987553) /Source="Nicolas_upshifts" /id="D1156" /incds=0 /nref=177 /ntot=215 /MaxReadThrough="1.81377" /MaxDrop="6.3089" /score="32.8866099" /energy="-9" /TU="U1733" /idTUdmin="U1732" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1988853..1989437) /gene="xpt" /locus_tag="BSU_22070" /old_locus_tag="BSU22070" /EC_number="2.4.2.22" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12923093, 15549109, 19381559, 20108980, 20200045" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12923093, 15549109, 19381559, 20108980, 20200045; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xanthine phosphoribosyltransferase" /protein_id="NP_390089.1" /db_xref="EnsemblGenomes-Gn:BSU22070" /db_xref="EnsemblGenomes-Tr:CAB14124" /db_xref="GOA:P42085" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR010079" /db_xref="InterPro:IPR029057" /db_xref="PDB:1Y0B" /db_xref="PDB:2FXV" /db_xref="SubtiList:BG11079" /db_xref="UniProtKB/Swiss-Prot:P42085" /translation="MEALKRKIEEEGVVLSDQVLKVDSFLNHQIDPLLMQRIGDEFAS RFAKDGITKIVTIESSGIAPAVMTGLKLGVPVVFARKHKSLTLTDNLLTASVYSFTKQ TESQIAVSGTHLSDQDHVLIIDDFLANGQAAHGLVSIVKQAGASIAGIGIVIEKSFQP GRDELVKLGYRVESLARIQSLEEGKVSFVQEVHS*" /label="xpt CDS" gene complement(1988853..1989437) /gene="xpt" /locus_tag="BSU_22070" /old_locus_tag="BSU22070" /label="xpt gene" misc_RNA complement(1989526..1989626) /gene="gswA" /locus_tag="BSU_misc_RNA_34" /product="guanine riboswitch" /experiment="publication(s) with functional evidences, PMID:12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477; Product type n: RNA" /label="gswA RNA" gene complement(1989526..1989626) /gene="gswA" /locus_tag="BSU_misc_RNA_34" /label="gswA gene" downshifts complement(1989533) /Source="Nicolas_upshifts" /id="D1157" /incds=0 /nref=8 /ntot=35 /MaxReadThrough="6.97435" /MaxDrop="3.25" /score="36.5247418" /energy="-19.2" /TU="U1732,U1733" /idTUdmin="U1734" /TUdmin=1870 /isTUend="FALSE" /label="downshifts" S_feature complement(1989627..1989767) /Source="Nicolas_S_feature" /locus_tag="new_2320214_2320354_c" /HighExp="dia15, BT, dia5, Diami, C90, LBGtran, Lbtran, Gly, SMMPr, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.291, 0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S835" CDS complement(1989768..1991273) /gene="ypwA" /locus_tag="BSU_22080" /old_locus_tag="BSU22080" /EC_number="3.4.17.19" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7765282, 22730127; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="metal-dependent carboxypeptidase" /protein_id="NP_390090.1" /db_xref="EnsemblGenomes-Gn:BSU22080" /db_xref="EnsemblGenomes-Tr:CAB14125" /db_xref="GOA:P50848" /db_xref="InterPro:IPR001333" /db_xref="PDB:3HQ2" /db_xref="SubtiList:BG11458" /db_xref="UniProtKB/Swiss-Prot:P50848" /translation="MEIHTYEKEFFDLLKRISHYSEAVALMHWDSRTGAPKNGSEDRA ESIGQLSTDIFNIQTSDRMKELIDVLYERFDDLSEDTKKAVELAKKEYEENKKIPEAE YKEYVILCSKAETAWEEAKGKSDFSLFSPYLEQLIEFNKRFITYWGYQEHPYDALLDL FEPGVTVKVLDQLFAELKEAIIPLVKQVTASGNKPDTSFITKAFPKEKQKELSLYFLQ ELGYDFDGGRLDETVHPFATTLNRGDVRVTTRYDEKDFRTAIFGTIHECGHAIYEQNI DEALSGTNLSDGASMGIHESQSLFYENFIGRNKHFWTPYYKKIQEASPVQFKDISLDD FVRAINESKPSFIRVEADELTYPLHIIIRYEIEKAIFSNEVSVEDLPSLWNQKYQDYL GITPQTDAEGILQDVHWAGGDFGYFPSYALGYMYAAQLKQKMLEDLPEFDALLERGEF HPIKQWLTEKVHIHGKRKKPLDIIKDATGEELNVRYLIDYLSNKYSNLYLL*" /label="ypwA CDS" gene complement(1989768..1991273) /gene="ypwA" /locus_tag="BSU_22080" /old_locus_tag="BSU22080" /label="ypwA gene" promotor_no_box complement(1991209..1991309) /Source="Nicolas_upshift_promotors" /id="U1732" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.382617382617383" /psig="0.290709290709291" /xcortree=1802 /SigmaFactorBS="ctgtaatggaacggctagaatagggagggaatggatatggag atacatacatatgaaaaagaattttttgatcttttaaaaagaatctcacattacagcg a" /listShort="ypwA, S835, NA, xpt, pbuX" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1991249) /Source="Nicolas_upshifts" /id="U1732" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.382617382617383" /psig="0.290709290709291" /xcortree=1802 /SigmaFactorBS="ctgtaatggaacggctagaatagggagggaatggatatggag atacatacatatgaaaaagaattttttgatcttttaaaaagaatctcacattacagcg a" /listShort="ypwA, S835, NA, xpt, pbuX" /GFF_Attribute="listLong" /label="upshifts" downshifts 1991261 /Source="Nicolas_upshifts" /id="D1158" /incds=0 /nref=4 /ntot=78 /MaxReadThrough="1.34397" /MaxDrop="3.87399" /score="12.6922524" /energy="-13.3" /TU="NA" /idTUdmin="U1735" /TUdmin="-5588" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1991299..1991318) /Source="Nicolas_upshift_promotors" /id="U1733" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.905094905094905" /psig="0.992007992007992" /xcortree=2219 /SigmaFactorBS="ctgccacaaaacataccggcagccttttatacaaacAATTTG ACtttcataccccctTCCATTAGCCTGTAATGGAAcggctagaatagggagggaatgg a" /listShort="ypwA, S835, NA, xpt, pbuX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1991315) /Source="Nicolas_upshifts" /id="U1733" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.905094905094905" /psig="0.992007992007992" /xcortree=2219 /SigmaFactorBS="ctgccacaaaacataccggcagccttttatacaaacAATTTG ACtttcataccccctTCCATTAGCCTGTAATGGAAcggctagaatagggagggaatgg a" /listShort="ypwA, S835, NA, xpt, pbuX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1991332..1991339) /Source="Nicolas_upshift_promotors" /id="U1733" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.905094905094905" /psig="0.992007992007992" /xcortree=2219 /SigmaFactorBS="ctgccacaaaacataccggcagccttttatacaaacAATTTG ACtttcataccccctTCCATTAGCCTGTAATGGAAcggctagaatagggagggaatgg a" /listShort="ypwA, S835, NA, xpt, pbuX" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1991385..1992377) /gene="kdgT" /locus_tag="BSU_22090" /old_locus_tag="BSU22090" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15849754, 16850406, 9846747; Product type t: transporter" /codon_start=1 /transl_table=11 /product="2-keto-3-deoxygluconate permease" /protein_id="NP_390091.1" /db_xref="EnsemblGenomes-Gn:BSU22090" /db_xref="EnsemblGenomes-Tr:CAB14126" /db_xref="GOA:P50847" /db_xref="InterPro:IPR004684" /db_xref="InterPro:IPR018395" /db_xref="SubtiList:BG11399" /db_xref="UniProtKB/Swiss-Prot:P50847" /translation="MKIKATIERVPGGMMIIPLFLGAALNTFAPGTAEFFGGFTGALI TGTLPILGVFIFCVGATIDFRSSGYIARKGITLLLGKIGFAALLGVIAAQFIPDDGIQ SGFFAGLSVLAIVAVMNETNGGLYLALMNHMGRKEDAGAFAFISTESGPFMTMVTFGV TGLAAFPWETLAATVIPFLLGCILGNLDHDLRDLFSKVVPAIIPFFAFSLGNTLNFGM LIQSGLLGIFIGVSVVILSGSSLFLLDRFIARGDGVAGVAASSTAGAAVAVPYALAEA NASFAPVAESATAIIATSVIVTSLLTPLATVWVDKKIKQKKRRTPPPKNQMTIN*" /label="kdgT CDS" gene complement(1991385..1992377) /gene="kdgT" /locus_tag="BSU_22090" /old_locus_tag="BSU22090" /label="kdgT gene" downshifts complement(1991403) /Source="Nicolas_upshifts" /id="D1159" /incds=0 /nref=15 /ntot=59 /MaxReadThrough="3.32882" /MaxDrop="5.85236" /score="36.5247418" /energy="-19.2" /TU="NA" /idTUdmin="U1734" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1992422..1993012) /gene="kdgA" /locus_tag="BSU_22100" /old_locus_tag="BSU22100" /EC_number="4.1.2.14" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9846747, 10368143; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-keto-3-deoxygluconate-6-phosphate aldolase" /protein_id="NP_390092.1" /db_xref="EnsemblGenomes-Gn:BSU22100" /db_xref="EnsemblGenomes-Tr:CAB14127" /db_xref="GOA:P50846" /db_xref="InterPro:IPR000887" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR031338" /db_xref="SubtiList:BG11396" /db_xref="UniProtKB/Swiss-Prot:P50846" /translation="MESKVVENRLKEAKLIAVIRSKDKQEACQQIESLLDKGIRAVEV TYTTPGASDIIESFRNREDILIGAGTVISAQQAGEAAKAGAQFIVSPGFSADLAEHLS FVKTHYIPGVLTPSEIMEALTFGFTTLKLFPSGVFGIPFMKNLAGPFPQVTFIPTGGI HPSEVPDWLRAGAGAVGVGSQLGSCSKEDLQAVFQV*" /label="kdgA CDS" gene complement(1992422..1993012) /gene="kdgA" /locus_tag="BSU_22100" /old_locus_tag="BSU22100" /label="kdgA gene" CDS complement(1993014..1993988) /gene="kdgK" /locus_tag="BSU_22110" /old_locus_tag="BSU22110" /EC_number="2.7.1.45" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9846747, 10368143, 15039578; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-keto-3-deoxygluconate kinase" /protein_id="NP_390093.1" /db_xref="EnsemblGenomes-Gn:BSU22110" /db_xref="EnsemblGenomes-Tr:CAB14128" /db_xref="GOA:P50845" /db_xref="InterPro:IPR002173" /db_xref="InterPro:IPR011611" /db_xref="InterPro:IPR029056" /db_xref="SubtiList:BG11397" /db_xref="UniProtKB/Swiss-Prot:P50845" /translation="MKLDAVTFGESMAMFYANEYGGLHEVSTFSKGLAGAESNVACGL ARLGFRMGWMSKVGNDQLGTFILQELKKEGVDVSRVIRSQDENPTGLLLKSKVKEGDP QVTYYRKNSAASTLTTAEYPRDYFQCAGHLHVTGIPPALSAEMKDFTYHVMNDMRNAG KTISFDPNVRPSLWPDQATMVHTINDLAGLADWFFPGIAEGELLTGEKTPEGIADYYL KKGASFVAIKLGKEGAYFKTGTSEGFLEGCRVDRVVDTVGAGDGFAVGVISGILDGLS YKDAVQRGNAIGALQVQAPGDMDGLPTREKLASFLSAQRTVHQKKGDY*" /label="kdgK CDS" gene complement(1993014..1993988) /gene="kdgK" /locus_tag="BSU_22110" /old_locus_tag="BSU22110" /label="kdgK gene" CDS complement(1994026..1995045) /gene="kdgR" /locus_tag="BSU_22120" /old_locus_tag="BSU22120" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9846747, 15223311, 17322190, 28040177" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9846747, 15223311, 17322190, 28040177; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of the Kdg operon (KdgR-galacturonate)" /protein_id="NP_390094.1" /db_xref="EnsemblGenomes-Gn:BSU22120" /db_xref="EnsemblGenomes-Tr:CAB14129" /db_xref="GOA:P50844" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR012310" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG11398" /db_xref="UniProtKB/Swiss-Prot:P50844" /translation="MKKKTTGHTTIKDVAECAGVSKSTVSRYINGKIDAISPEKVKNI KKAIAELNYRPSKMAQGLKIKKSKLIGFVVADITNPFSVAAFRGVEEVCDQYGYSIMV CNTDNSPEKEREMLLKLEAHSVEGLILNATGENKDVLRAFAEQQIPTILIDRKLPDLK LDTVTTDNRWITKEILQKVYSKGYTDVALFTEPISSISPRAERAAVYQEMASVQNVNG LVRLHEIDVKDKEQLKAELRSFHKEMPEQKKAILALNGLIMLKIISCMEELGLRIPQD IGIAGFDDTEWYKLIGPGITTIAQPSHDMGRTAMERVLKRIEGDKGAPQTIELEAKVI MRKSL*" /label="kdgR CDS" gene complement(1994026..1995045) /gene="kdgR" /locus_tag="BSU_22120" /old_locus_tag="BSU22120" /label="kdgR gene" promotor_-10 complement(1995093..1995112) /Source="Nicolas_upshift_promotors" /id="U1734" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.827172827172827" /psig=1 /xcortree=3226 /SigmaFactorBS="aaaataatgaattgacatattattaaaaaaacTCTTCCCAaa ttttaaaatTATGGTATTCTTTTGTTGTAacggttttgaaatcggtttcaaatatatg a" /listShort="kdgR, kdgK, kdgA, kdgT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1995103) /Source="Nicolas_upshifts" /id="U1734" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.827172827172827" /psig=1 /xcortree=3226 /SigmaFactorBS="aaaataatgaattgacatattattaaaaaaacTCTTCCCAaa ttttaaaatTATGGTATTCTTTTGTTGTAacggttttgaaatcggtttcaaatatatg a" /listShort="kdgR, kdgK, kdgA, kdgT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1995124..1995131) /Source="Nicolas_upshift_promotors" /id="U1734" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.827172827172827" /psig=1 /xcortree=3226 /SigmaFactorBS="aaaataatgaattgacatattattaaaaaaacTCTTCCCAaa ttttaaaatTATGGTATTCTTTTGTTGTAacggttttgaaatcggtttcaaatatatg a" /listShort="kdgR, kdgK, kdgA, kdgT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1995166..1995173 /Source="Nicolas_upshift_promotors" /id="U1735" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3227 /SigmaFactorBS="gaagagtttttttaataatatgtcaattcattattttttCGT TGACTcttttcactatttaTCCTAAAATTTTCTTTGAAAccgttaccaaaatattttc a" /listShort="S836, kduI, kduD" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1995187..1995266 /Source="Nicolas_S_feature" /locus_tag="new_2325774_2325853" /HighExp="HiTm, Heat, nit, LBGstat, ferm, T-0.40H, HiOs, T1.30H, MG 150, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S836" upshifts 1995187 /Source="Nicolas_upshifts" /id="U1735" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3227 /SigmaFactorBS="gaagagtttttttaataatatgtcaattcattattttttCGT TGACTcttttcactatttaTCCTAAAATTTTCTTTGAAAccgttaccaaaatattttc a" /listShort="S836, kduI, kduD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1995188..1995207 /Source="Nicolas_upshift_promotors" /id="U1735" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3227 /SigmaFactorBS="gaagagtttttttaataatatgtcaattcattattttttCGT TGACTcttttcactatttaTCCTAAAATTTTCTTTGAAAccgttaccaaaatattttc a" /listShort="S836, kduI, kduD" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1995267..1996094 /gene="kduI" /locus_tag="BSU_22130" /old_locus_tag="BSU22130" /EC_number="5.3.1.17" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15528647, 23437267, 27227414; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase, 5-keto-4-deoxyuronate isomerase" /protein_id="NP_390095.1" /db_xref="EnsemblGenomes-Gn:BSU22130" /db_xref="EnsemblGenomes-Tr:CAB14130" /db_xref="GOA:P50843" /db_xref="InterPro:IPR007045" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR021120" /db_xref="InterPro:IPR027449" /db_xref="SubtiList:BG11401" /db_xref="UniProtKB/Swiss-Prot:P50843" /translation="MENRYSVHPEQVKRFTTEELRSHFLMDSLFTENKLTMYYSHEDR VVIGGAAPGQSELKLDAGDFLKTDFFLERREIGIINVGQPGAVRVGDDEYVLQTKDFL YIGMGNQDVSFSSLNGEKAKFYFVSACAHKSYPTQKAALSELTPDRLGDDAASNVRSL YKVIHQDGIKSCQLMMGITMLDQNNNWNTMPAHVHDRRMEAYLYLDLEKDSKVFHFMG QPDETRHLVVGNEQAVLSPAWSIHSGAGTSNYSFVWAMAGENYTFTDMDLIPMDGLK* " /label="kduI CDS" gene 1995267..1996094 /gene="kduI" /locus_tag="BSU_22130" /old_locus_tag="BSU22130" /label="kduI gene" CDS 1996096..1996860 /gene="kduD" /locus_tag="BSU_22140" /old_locus_tag="BSU22140" /EC_number="1.1.1.127" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15528647, 24509771, 27028675; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-keto-3-deoxygluconate oxidoreductase" /protein_id="NP_390096.1" /db_xref="EnsemblGenomes-Gn:BSU22140" /db_xref="EnsemblGenomes-Tr:CAB14131" /db_xref="GOA:P50842" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR011286" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11400" /db_xref="UniProtKB/Swiss-Prot:P50842" /translation="MGYLHDAFSLKGKTALVTGPGTGIGQGIAKALAGAGADIIGTSH TSSLSETQQLVEQEGRIFTSFTLDMSKPEAIKDSAAELFENRQIDILVNNAGIIHREK AEDFPEENWQHVLNVNLNSLFILTQLAGRHMLKRGHGKIINIASLLSFQGGILVPAYT ASKHAVAGLTKSFANEWAASGIQVNAIAPGYISTANTKPIRDDEKRNEDILKRIPAGR WGQADDIGGTAVFLASRASDYVNGHILAVDGGWLSR*" /label="kduD CDS" gene 1996096..1996860 /gene="kduD" /locus_tag="BSU_22140" /old_locus_tag="BSU22140" /label="kduD gene" downshifts 1996849 /Source="Nicolas_upshifts" /id="D1160" /incds=0 /nref=12 /ntot=160 /MaxReadThrough="0.66029" /MaxDrop="3.56178" /score="23.0070487" /energy="-12.3" /TU="NA" /idTUdmin="U1735" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1996891) /Source="Nicolas_upshifts" /id="D1161" /incds=0 /nref=28 /ntot=225 /MaxReadThrough="1.88107" /MaxDrop="5.27501" /score="35.5168663" /energy="-12.3" /TU="NA" /idTUdmin="U1736" /TUdmin="-10" /isTUend="TRUE" /label="downshifts" CDS complement(1996901..1998826) /gene="ypvA" /locus_tag="BSU_22150" /old_locus_tag="BSU22150" /EC_number="3.6.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8385320, 17114254; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ATP-dependent helicase" /protein_id="NP_390097.1" /db_xref="EnsemblGenomes-Gn:BSU22150" /db_xref="EnsemblGenomes-Tr:CAB14132" /db_xref="GOA:P50831" /db_xref="InterPro:IPR006555" /db_xref="InterPro:IPR014013" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11457" /db_xref="UniProtKB/Swiss-Prot:P50831" /translation="MTTSRLPFSLTKTKNFYEELNNWIGDVFYDILPEKGFDLRDEQV FMAFQLERAFKEKKVMFAEAGVGTGKTLVYLLFAISYARYVGKPAIIACADETLIEQL VKKEGDISKLAEHLDLKIDTRLSKSHEQYLCLKKLEKTMQRSDDDKWLDLYESLPSFV HESQAMQRFYPYGDRKQYANLSNEEWSDVSYDSFQDCLTCDMRHRCGLTLSRDYYRKS TDLIICSHDFYMEHVWTEESRKREGQLPLLPDHSAVVFDEGHLLEFAAQKALTYRVKQ STLELFLERLLQNDIREEFAELIEDALLANDEFFYVLSEESKEVAGSHRLEIKNDHRV KKAADELCRLLDKIGEALVFESEMYTIDQYELSVVEEYVEQMAYSLSLYQKDAISWLE KKEAESTFVVMPRTVAEVLGEKVFSKKIPYIFSSATLSEGGSFDYIADSLGIHDYLSL TVDSPYDYDEQMSINLYAKTDMDAEQKTAETIETIKRYKGRTLVLFPSFEELNEFKEL SAAWELPYPIFFEGDEEISSLVEKFQEEEETVLCSVHLWEGLDIPGDALKNVTIWSLP FPPHDPVFTAKRNGAKKDPFEEVDLPYMLLRVRQGIGRLIRSNQDSGSIHIYAGGENE RIIDEVKKVLPVEPHMM*" /label="ypvA CDS" gene complement(1996901..1998826) /gene="ypvA" /locus_tag="BSU_22150" /old_locus_tag="BSU22150" /label="ypvA gene" promotor_-10 complement(1998857..1998876) /Source="Nicolas_upshift_promotors" /id="U1736" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.53946053946054" /psig=1 /xcortree=2498 /SigmaFactorBS="aaaaacttggcattgccaagttttttATTGTattcatcagcg gaaAATGATATTATTGGTGGTCTgaatgtcgaatagttgggggttggaactaggtgac a" /listShort="ypvA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1998861) /Source="Nicolas_upshifts" /id="U1736" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.53946053946054" /psig=1 /xcortree=2498 /SigmaFactorBS="aaaaacttggcattgccaagttttttATTGTattcatcagcg gaaAATGATATTATTGGTGGTCTgaatgtcgaatagttgggggttggaactaggtgac a" /listShort="ypvA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1998863..1998927) /Source="Nicolas_S_feature" /locus_tag="new_2329450_2329514_c" /HighExp="S3, S4, S8, S7, LoTm, S5, S6, BT, G180, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.999, 1" /TUlongSig="SigA, SigA, SigA, SigA" /TUlongPSig="0.998, 1, 0.998, 1" /label="S837" promotor_-35 complement(1998891..1998895) /Source="Nicolas_upshift_promotors" /id="U1736" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.53946053946054" /psig=1 /xcortree=2498 /SigmaFactorBS="aaaaacttggcattgccaagttttttATTGTattcatcagcg gaaAATGATATTATTGGTGGTCTgaatgtcgaatagttgggggttggaactaggtgac a" /listShort="ypvA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1998928..1999119) /gene="yptA" /locus_tag="BSU_22160" /old_locus_tag="BSU22160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_390098.1" /db_xref="EnsemblGenomes-Gn:BSU22160" /db_xref="EnsemblGenomes-Tr:CAB14133" /db_xref="SubtiList:BG11456" /db_xref="UniProtKB/Swiss-Prot:P50841" /translation="MLNSEHFNLIQRALDATANELKELGTDSSPSVISHAQTDLEKAV EHIYSTDHPFLSSHVINRK*" /label="yptA CDS" gene complement(1998928..1999119) /gene="yptA" /locus_tag="BSU_22160" /old_locus_tag="BSU22160" /label="yptA gene" promotor_-10 complement(1999138..1999156) /Source="Nicolas_upshift_promotors" /id="U1737" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1119 /SigmaFactorBS="catgtttcggtgataacatgcggtaaagcaTGTATAtaaaat gaaaagttcGCATACAATGATGATTATTtccatcagaggtgatctcatgctgaacagc g" /listShort="yptA, S837, ypvA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1999147) /Source="Nicolas_upshifts" /id="U1737" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1119 /SigmaFactorBS="catgtttcggtgataacatgcggtaaagcaTGTATAtaaaat gaaaagttcGCATACAATGATGATTATTtccatcagaggtgatctcatgctgaacagc g" /listShort="yptA, S837, ypvA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1999149..1999454) /Source="Nicolas_S_feature" /locus_tag="new_2329736_2330041_c" /HighExp="Cold, G135, G180, C30, G150, Oxctl, Paraq, H2O2, LBGstat, LPh" /AntisenseName="ypzG" /AntisenseCor="-0.39420155633160697" /AntisenseRegPval="-10.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA, SigA, SigA" /TUlongPSig="0.998, 1, 0.998, 1" /label="S838" promotor_-35 complement(1999172..1999177) /Source="Nicolas_upshift_promotors" /id="U1737" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1119 /SigmaFactorBS="catgtttcggtgataacatgcggtaaagcaTGTATAtaaaat gaaaagttcGCATACAATGATGATTATTtccatcagaggtgatctcatgctgaacagc g" /listShort="yptA, S837, ypvA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1999186..1999192 /Source="Nicolas_upshift_promotors" /id="U1738" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=859 /SigmaFactorBS="cgaacttttcattttatatacatgctttacCGCATGTtatca ccgaaacatGCACAAACTACActtgatattccgtctccggattatccgtcttatcaac a" /listShort="ypzG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1999207..1999218 /Source="Nicolas_upshift_promotors" /id="U1738" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=859 /SigmaFactorBS="cgaacttttcattttatatacatgctttacCGCATGTtatca ccgaaacatGCACAAACTACActtgatattccgtctccggattatccgtcttatcaac a" /listShort="ypzG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1999216 /Source="Nicolas_upshifts" /id="U1738" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=859 /SigmaFactorBS="cgaacttttcattttatatacatgctttacCGCATGTtatca ccgaaacatGCACAAACTACActtgatattccgtctccggattatccgtcttatcaac a" /listShort="ypzG" /GFF_Attribute="listLong" /label="upshifts" CDS 1999283..1999435 /gene="ypzG" /locus_tag="BSU_22169" /old_locus_tag="BSU22169" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097754.1" /db_xref="EnsemblGenomes-Gn:BSU22169" /db_xref="EnsemblGenomes-Tr:CAX52653" /db_xref="InterPro:IPR025413" /db_xref="UniProtKB/Swiss-Prot:C0H444" /translation="MSYRNRLDQHSELFHHNWTRPKRSKSQVNGHTEMSQTNIILRSN AKAHRW*" /label="ypzG CDS" gene 1999283..1999435 /gene="ypzG" /locus_tag="BSU_22169" /old_locus_tag="BSU22169" /label="ypzG gene" downshifts 1999445 /Source="Nicolas_upshifts" /id="D1162" /incds=0 /nref=35 /ntot=65 /MaxReadThrough="1.2837" /MaxDrop="7.64655" /score="-9.36260071" /energy="-16.3" /TU="NA" /idTUdmin="U1738" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1999488..2000645) /gene="rlmKB" /locus_tag="BSU_22170" /old_locus_tag="BSU22170" /EC_number="2.1.1.264" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 22210896, 22362734; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="m(7)G2069 methylase of 23S rRNA" /protein_id="NP_390099.1" /db_xref="EnsemblGenomes-Gn:BSU22170" /db_xref="EnsemblGenomes-Tr:CAB14134" /db_xref="GOA:P50840" /db_xref="InterPro:IPR000241" /db_xref="InterPro:IPR002052" /db_xref="InterPro:IPR004114" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11455" /db_xref="UniProtKB/Swiss-Prot:P50840" /translation="MKKYTLIATAPMGIEAVVAKEVRDLGYECKVDNGKVIFEGDALA ICRANLWLRTADRIKVQVASFKAKTFDELFEKTKAINWRSFIPENGKFPVIGKSVKST LASVPDCQRIVKKAIVEKLKLQSGKANDWIEETGAEYKVEISLLKDQALITLDSSGTG LHKRGYRVDQGGAPIKETLAAALVQLTNWTPDRPFVDPFCGSGTIAIEAALIGQNIAP GFNRDFVSEDWEWIGKDLWNKARLEVEEKANYDQPLTIFASDIDHRMVQIAKENAEEA GLGDLIQFKQMQVKDFTTNLEFGVIVGNPPYGERLGEKKAVEQMYKEMGQAFEPLDTW SVYMLTSNENFEEAYGRKATKKRKLFNGFIKTDYYQYWSKVRPQRKKTENA*" /label="rlmKB CDS" gene complement(1999488..2000645) /gene="rlmKB" /locus_tag="BSU_22170" /old_locus_tag="BSU22170" /label="rlmKB gene" downshifts complement(1999499) /Source="Nicolas_upshifts" /id="D1163" /incds=0 /nref=86 /ntot=240 /MaxReadThrough="4.31441" /MaxDrop="4.58268" /score="14.6684819" /energy="-6.2" /TU="U1739" /idTUdmin="U1740" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_RNA complement(2000733..2001133) /gene="rnpB" /locus_tag="BSU_misc_RNA_35" /product="RNA component of ribonuclease P (RNase P) (catalytic subunit, ribozyme)" /experiment="publication(s) with functional evidences, PMID:1699929, 16980484, 17919279, 22448220" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1699929, 16980484, 17919279, 22448220; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rnpB RNA" gene complement(2000733..2001133) /gene="rnpB" /locus_tag="BSU_misc_RNA_35" /label="rnpB gene" downshifts complement(2000743) /Source="Nicolas_upshifts" /id="D1164" /incds=0 /nref=200 /ntot=276 /MaxReadThrough="6.17541" /MaxDrop="7.4677" /score="0.20729905" /energy="-10.4" /TU="U1739,U1740" /idTUdmin="U1742" /TUdmin=406 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2001130..2001149) /Source="Nicolas_upshift_promotors" /id="U1739" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.684315684315684" /psig=1 /xcortree=288 /SigmaFactorBS="gcaagctttatgattgatcacgcttgaaaaaaatggcgCTTG TAAattgtaatcagttgTTATATAATAATTCATGTTCttaacgttcgggtaatcgctg c" /listShort="rnpB, ypsC, S838, yptA, S837, ypvA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2001148) /Source="Nicolas_upshifts" /id="U1739" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.684315684315684" /psig=1 /xcortree=288 /SigmaFactorBS="gcaagctttatgattgatcacgcttgaaaaaaatggcgCTTG TAAattgtaatcagttgTTATATAATAATTCATGTTCttaacgttcgggtaatcgctg c" /listShort="rnpB, ypsC, S838, yptA, S837, ypvA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2001164..2001170) /Source="Nicolas_upshift_promotors" /id="U1739" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.684315684315684" /psig=1 /xcortree=288 /SigmaFactorBS="gcaagctttatgattgatcacgcttgaaaaaaatggcgCTTG TAAattgtaatcagttgTTATATAATAATTCATGTTCttaacgttcgggtaatcgctg c" /listShort="rnpB, ypsC, S838, yptA, S837, ypvA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2001192..2001488) /gene="gpsB" /locus_tag="BSU_22180" /old_locus_tag="BSU22180" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:18363795, 18776011, 19429628, 25845974, 27257764" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18363795, 18776011, 19429628, 25845974, 27257764; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell division protein" /protein_id="NP_390100.1" /db_xref="EnsemblGenomes-Gn:BSU22180" /db_xref="EnsemblGenomes-Tr:CAB14135" /db_xref="GOA:P0CI74" /db_xref="InterPro:IPR007793" /db_xref="InterPro:IPR011229" /db_xref="InterPro:IPR019933" /db_xref="PDB:4UG3" /db_xref="PDB:5AN5" /db_xref="SubtiList:BG11454" /db_xref="UniProtKB/Swiss-Prot:P0CI74" /translation="MLADKVKLSAKEILEKEFKTGVRGYKQEDVDKFLDMIIKDYETF HQEIEELQQENLQLKKQLEEASKKQPVQSNTTNFDILKRLSNLEKHVFGSKLYD*" /label="gpsB CDS" gene complement(2001192..2001488) /gene="gpsB" /locus_tag="BSU_22180" /old_locus_tag="BSU22180" /label="gpsB gene" promotor_-10 complement(2001513..2001532) /Source="Nicolas_upshift_promotors" /id="U1740" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.712287712287712" /psig="0.998001998001998" /xcortree=3143 /SigmaFactorBS="gaggaagacagctactaacaatgagagagaAATTTGACaacc gtacagattTCTGAAAAAATATATGTGATgattcacgatacgaggtgaaaaagatgct t" /listShort="gpsB, rnpB, ypsC" /listLong="S838, yptA, S837, ypvA" /label="promotor_-10" upshifts complement(2001523) /Source="Nicolas_upshifts" /id="U1740" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.712287712287712" /psig="0.998001998001998" /xcortree=3143 /SigmaFactorBS="gaggaagacagctactaacaatgagagagaAATTTGACaacc gtacagattTCTGAAAAAATATATGTGATgattcacgatacgaggtgaaaaagatgct t" /listShort="gpsB, rnpB, ypsC" /listLong="S838, yptA, S837, ypvA" /label="upshifts" promotor_-35 complement(2001546..2001553) /Source="Nicolas_upshift_promotors" /id="U1740" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.712287712287712" /psig="0.998001998001998" /xcortree=3143 /SigmaFactorBS="gaggaagacagctactaacaatgagagagaAATTTGACaacc gtacagattTCTGAAAAAATATATGTGATgattcacgatacgaggtgaaaaagatgct t" /listShort="gpsB, rnpB, ypsC" /listLong="S838, yptA, S837, ypvA" /label="promotor_-35" CDS complement(2001566..2002195) /gene="ypsA" /locus_tag="BSU_22190" /old_locus_tag="BSU22190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390101.2" /db_xref="EnsemblGenomes-Gn:BSU22190" /db_xref="EnsemblGenomes-Tr:CAB14136" /db_xref="InterPro:IPR010697" /db_xref="PDB:2NX2" /db_xref="SubtiList:BG11453" /db_xref="UniProtKB/Swiss-Prot:P50838" /translation="MENVQLDGVNNAAQQMGPTGAPFFKAGEMMKVLAITGYKPFELG IFKQDDKALYYIKKAIKNRLIAFLDEGLEWILISGQLGVELWAAEAAYDLQEEYPDLK VAVITPFYEQEKNWKEPNKEQYEAVLAQADYEASLTHRPYESPLQFKQKNQFFIDKSD GLLLLYDPEKEGSPKYMLGTAEKRREQDGYPIYFITMDDLRVTVEEDSY*" /label="ypsA CDS" gene complement(2001566..2002195) /gene="ypsA" /locus_tag="BSU_22190" /old_locus_tag="BSU22190" /label="ypsA gene" downshifts complement(2002161) /Source="Nicolas_upshifts" /id="D1165" /incds=0 /nref=37 /ntot=160 /MaxReadThrough="5.74028" /MaxDrop="8.12374" /score="7.18626302" /energy="-9.8" /TU="U1741,U1742" /idTUdmin="U1744" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2002197..2002424) /gene="cotD" /locus_tag="BSU_22200" /old_locus_tag="BSU22200" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:2821284, 10075739, 10400595, 1518043, 1691789, 19933362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2821284, 10075739, 10400595, 1518043, 1691789, 19933362; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="spore coat protein (inner)" /protein_id="NP_390102.1" /db_xref="EnsemblGenomes-Gn:BSU22200" /db_xref="EnsemblGenomes-Tr:CAB14137" /db_xref="GOA:P07791" /db_xref="InterPro:IPR020108" /db_xref="SubtiList:BG10493" /db_xref="UniProtKB/Swiss-Prot:P07791" /translation="MHHCRPHMMAPIVHPTHCCEHHTFSKTIVPHIHPQHTTNVNHQH FQHVHYFPHTFSNVDPATHQHFQAGKPCCDY*" /label="cotD CDS" gene complement(2002197..2002424) /gene="cotD" /locus_tag="BSU_22200" /old_locus_tag="BSU22200" /label="cotD gene" promotor_-10 complement(2002452..2002471) /Source="Nicolas_upshift_promotors" /id="U1741" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1359 /SigmaFactorBS="gcttaattgcacacttttaaaataggtctttgcaTCAGAACA TgtaccccttatttTTCATAACTTAGTATTGTAAtaaagtttatggaaaggggatttt a" /listShort="cotD, ypsA" /listLong="gpsB, rnpB, ypsC" /label="promotor_-10" upshifts complement(2002467) /Source="Nicolas_upshifts" /id="U1741" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1359 /SigmaFactorBS="gcttaattgcacacttttaaaataggtctttgcaTCAGAACA TgtaccccttatttTTCATAACTTAGTATTGTAAtaaagtttatggaaaggggatttt a" /listShort="cotD, ypsA" /listLong="gpsB, rnpB, ypsC" /label="upshifts" S_feature complement(2002469..2002623) /Source="Nicolas_S_feature" /locus_tag="new_2333056_2333210_c" /HighExp="LBGexp, dia15, Paraq, H2O2, Heat, G135, UNK1, Lbexp, BMM, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.808141" /TUshortSig="SigA, Sig-, SigA, SigA" /TUshortPSig="1, 0.419, 0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S839" promotor_-35 complement(2002485..2002493) /Source="Nicolas_upshift_promotors" /id="U1741" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1359 /SigmaFactorBS="gcttaattgcacacttttaaaataggtctttgcaTCAGAACA TgtaccccttatttTTCATAACTTAGTATTGTAAtaaagtttatggaaaggggatttt a" /listShort="cotD, ypsA" /listLong="gpsB, rnpB, ypsC" /label="promotor_-35" CDS complement(2002508..2002636) /locus_tag="BSU_22205" /old_locus_tag="BSU22205" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_009513975.1" /translation="MTLVIFKGRVGMYKGVFYLFFVVVFLIAFVFSNFKDSLIAHF*" /label="conserved protein of unknown function CDS" gene complement(2002508..2002636) /locus_tag="BSU_22205" /old_locus_tag="BSU22205" /label="gene" upshifts complement(2002623) /Source="Nicolas_upshifts" /id="U1742" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.592407592407592" /psig=1 /xcortree=2670 /SigmaFactorBS="ctgaattcacattgatttTGTTGtagaatagcggcgaaTCCT GTAAAATGACGTTAGTtatttttaaagggagagttggtatgtataagggtgtttttta c" /listShort="S839, cotD, ypsA, gpsB" /listLong="rnpB, ypsC, S838, yptA, S837, ypvA" /label="upshifts" S_feature complement(2002625..2002736) /Source="Nicolas_S_feature" /locus_tag="new_2333212_2333323_c" /HighExp="Sw, M40t90, Etha, Salt, M40t45, H2O2, S8, S6, G135, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigA" /TUshortPSig="0.419, 0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S840" promotor_-10 complement(2002626..2002645) /Source="Nicolas_upshift_promotors" /id="U1742" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.592407592407592" /psig=1 /xcortree=2670 /SigmaFactorBS="ctgaattcacattgatttTGTTGtagaatagcggcgaaTCCT GTAAAATGACGTTAGTtatttttaaagggagagttggtatgtataagggtgtttttta c" /listShort="S839, cotD, ypsA, gpsB" /listLong="rnpB, ypsC, S838, yptA, S837, ypvA" /label="promotor_-10" promotor_-35 complement(2002661..2002665) /Source="Nicolas_upshift_promotors" /id="U1742" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.592407592407592" /psig=1 /xcortree=2670 /SigmaFactorBS="ctgaattcacattgatttTGTTGtagaatagcggcgaaTCCT GTAAAATGACGTTAGTtatttttaaagggagagttggtatgtataagggtgtttttta c" /listShort="S839, cotD, ypsA, gpsB" /listLong="rnpB, ypsC, S838, yptA, S837, ypvA" /label="promotor_-35" CDS complement(2002737..2003978) /gene="yprB" /locus_tag="BSU_22210" /old_locus_tag="BSU22210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23249255; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative nucleic acid binding enzyme" /protein_id="NP_390103.1" /db_xref="EnsemblGenomes-Gn:BSU22210" /db_xref="EnsemblGenomes-Tr:CAB14138" /db_xref="GOA:P50837" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG11452" /db_xref="UniProtKB/Swiss-Prot:P50837" /translation="MSLKGKLQRMKKHMALDEGEQKIEAGKQENHFDDIPFLEEWEAF GMKPFIFEDEYCLIREVEYPLSHRHGLYSFSELEEVITLWNQSGLSHTLSAKGYNKNN LFFFDTETTGLGGGAGNTIFLLGHARVYEDRVTVKQHLLPKPGNEVALYQSFLSEVDI TSLVTYNGKAFDWPQVKTRHTLIRDRLPKLPEFGHFDLLHGARRLWKHKMDRVSLGTV EKEELGIRRLEDTPGYLAPMLYFHFIKAQEPDLLKGVLHHNEMDVLSLISLYIHMSKK ILSESHAPKEHSEAYAMAKWFMAHKETDQAIKQLERLIEKSFEDQDSARLDLSLLYKK QNRLEEAVPLWEKLSRSQNQKCRYAAVIELAKYFEHKKKEFGKALQVAEQSLSDAACL SEKETEKLHVRIARLKRKYSS*" /label="yprB CDS" gene complement(2002737..2003978) /gene="yprB" /locus_tag="BSU_22210" /old_locus_tag="BSU22210" /label="yprB gene" promotor_-10 complement(2003692..2003710) /Source="Nicolas_upshift_promotors" /id="U1743" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.418581418581419" /psig="0.418581418581419" /xcortree=723 /SigmaFactorBS="gcttttctgagcttgaggaagtgatcacaCTGTGGAAtcaaa gcggcctgtCGCATACATTGTCAGCAAAagggtataacaaaaacaacctctttttctt t" /listShort="S840, S839" /listLong="cotD" /label="promotor_-10" upshifts complement(2003701) /Source="Nicolas_upshifts" /id="U1743" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.418581418581419" /psig="0.418581418581419" /xcortree=723 /SigmaFactorBS="gcttttctgagcttgaggaagtgatcacaCTGTGGAAtcaaa gcggcctgtCGCATACATTGTCAGCAAAagggtataacaaaaacaacctctttttctt t" /listShort="S840, S839" /listLong="cotD" /label="upshifts" promotor_-35 complement(2003725..2003732) /Source="Nicolas_upshift_promotors" /id="U1743" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.418581418581419" /psig="0.418581418581419" /xcortree=723 /SigmaFactorBS="gcttttctgagcttgaggaagtgatcacaCTGTGGAAtcaaa gcggcctgtCGCATACATTGTCAGCAAAagggtataacaaaaacaacctctttttctt t" /listShort="S840, S839" /listLong="cotD" /label="promotor_-35" CDS complement(2003994..2006243) /gene="yprA" /locus_tag="BSU_22220" /old_locus_tag="BSU22220" /EC_number="3.6.4.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ATP-dependent RNA helicase" /protein_id="NP_390104.1" /db_xref="EnsemblGenomes-Gn:BSU22220" /db_xref="EnsemblGenomes-Tr:CAB14139" /db_xref="GOA:P50830" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR018973" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11451" /db_xref="UniProtKB/Swiss-Prot:P50830" /translation="MKKKSLTELISDLKGNENVVNWHEIEPREAKTRPMPESIDERIK AALSKRGIDELYTHQYSAFQYVQKGESIVTVTPTASGKTLCYNLPVLQSIAQDETNRA LYLFPTKALAQDQKSELNEIIDEMGIDIKSFTYDGDTSPAIRQKVRKAGHIVITNPDM LHSAILPHHTKWVSLFENLKYIVIDELHTYRGVFGSHVANVIRRLKRICRFYGSDPVF ICTSATIANPKELGEQLTGKPMRLVDDNGAPSGRKHFVFYNPPIVNKPLNIRRSATAE VNELAKEFLKNKVQTIVFARSRVRVEIILSHIQELVKKEIGTKSIRGYRGGYLPKERR EIERGLREGDILGVVSTNALELGVDIGQLQVCVMTGYPGSVASAWQQAGRAGRRHGES LIIMVANSTPIDQYIVRHPEYFFNRSPESARINPENLIILVDHLKCAAYELPFRADEE FGAMEVSDILEYLQEEAVLHRNGERYHWASESFPASNISLRSASQENVVIVDQSDIAN VRIIGEMDRFSAMTLLHDEAIYLHEGVQYQVEKLDWDHKKAYVRKVDVEYYTDANLAV QLKVLEIDKTKEKSRTSLHYGDVTVNALPTIFKKIKMTTFENIGSGPIHLPEEELHTS AAWLEIKTADEDIGEKTLEQLLLGISNVLQHIVPVYIMCDRNDVHVVSQIKAAHTGLP TIFLYDHYPGGIGLAEEVFKRFSDINEAAKQLITHCPCHDGCPSCIGTEIEGIKAKER ILQLLDQMS*" /label="yprA CDS" gene complement(2003994..2006243) /gene="yprA" /locus_tag="BSU_22220" /old_locus_tag="BSU22220" /label="yprA gene" promotor_-10 complement(2006259..2006278) /Source="Nicolas_upshift_promotors" /id="U1744" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.362637362637363" /psig="0.998001998001998" /xcortree=2675 /SigmaFactorBS="tgccttgctttttttattcaactgtataaaatttgcaCCTAG CCatgcaaacaaataTTCGGTAAACTGTACTTGACaaagaggtgtaaagaatgaaaaa g" /listShort="yprA, yprB, S840, S839, cotD" /listLong="ypsA, gpsB, rnpB, ypsC, S838, yptA, S837, ypvA" /label="promotor_-10" upshifts complement(2006275) /Source="Nicolas_upshifts" /id="U1744" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.362637362637363" /psig="0.998001998001998" /xcortree=2675 /SigmaFactorBS="tgccttgctttttttattcaactgtataaaatttgcaCCTAG CCatgcaaacaaataTTCGGTAAACTGTACTTGACaaagaggtgtaaagaatgaaaaa g" /listShort="yprA, yprB, S840, S839, cotD" /listLong="ypsA, gpsB, rnpB, ypsC, S838, yptA, S837, ypvA" /label="upshifts" promotor_-35 complement(2006292..2006298) /Source="Nicolas_upshift_promotors" /id="U1744" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.362637362637363" /psig="0.998001998001998" /xcortree=2675 /SigmaFactorBS="tgccttgctttttttattcaactgtataaaatttgcaCCTAG CCatgcaaacaaataTTCGGTAAACTGTACTTGACaaagaggtgtaaagaatgaaaaa g" /listShort="yprA, yprB, S840, S839, cotD" /listLong="ypsA, gpsB, rnpB, ypsC, S838, yptA, S837, ypvA" /label="promotor_-35" CDS complement(2006346..2006852) /gene="ypqE" /locus_tag="BSU_22230" /old_locus_tag="BSU22230" /EC_number="2.7.1.-" /function="16.1: Circulate" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10627040, 28731580; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphotransferase system enzyme IIA component" /protein_id="NP_390105.1" /db_xref="EnsemblGenomes-Gn:BSU22230" /db_xref="EnsemblGenomes-Tr:CAB14140" /db_xref="GOA:P50829" /db_xref="InterPro:IPR001127" /db_xref="InterPro:IPR011055" /db_xref="SubtiList:BG11450" /db_xref="UniProtKB/Swiss-Prot:P50829" /translation="MLKKLFGMGKIQEKVTEEVIYSPADGTVMDLSDVPDPVFSQKMM GEGIAVEPSSGEIVSPAEGEVIQIFHTKHAVGIRTRSGIELLIHVGLETVNMNGEGFT AHIKEGDKVKVGDPLITCDLELIKEKASSTVIPIVIMNGEAVGSMVSAGEKAARKGES KLFTIKAK*" /label="ypqE CDS" gene complement(2006346..2006852) /gene="ypqE" /locus_tag="BSU_22230" /old_locus_tag="BSU22230" /label="ypqE gene" downshifts complement(2006369) /Source="Nicolas_upshifts" /id="D1166" /incds=0 /nref=88 /ntot=236 /MaxReadThrough="4.55156" /MaxDrop="6.1724" /score="32.5355561" /energy="-10.2" /TU="U1745" /idTUdmin="U1747" /TUdmin=808 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2006896..2006915) /Source="Nicolas_upshift_promotors" /id="U1745" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.704295704295704" /psig=1 /xcortree=3134 /SigmaFactorBS="tttaaccagattatgcgtctatgccagatgttgttatAAATT GAAgcaaaattgaaagTGTGGTTAAATAGTGGTGAAtgaagggataacggttgaagtg a" /listShort="ypqE, yprA, yprB, S840, S839, cotD" /listLong="ypsA, gpsB, rnpB, ypsC, S838, yptA, S837, ypvA" /label="promotor_-10" upshifts complement(2006913) /Source="Nicolas_upshifts" /id="U1745" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.704295704295704" /psig=1 /xcortree=3134 /SigmaFactorBS="tttaaccagattatgcgtctatgccagatgttgttatAAATT GAAgcaaaattgaaagTGTGGTTAAATAGTGGTGAAtgaagggataacggttgaagtg a" /listShort="ypqE, yprA, yprB, S840, S839, cotD" /listLong="ypsA, gpsB, rnpB, ypsC, S838, yptA, S837, ypvA" /label="upshifts" promotor_-35 complement(2006929..2006936) /Source="Nicolas_upshift_promotors" /id="U1745" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.704295704295704" /psig=1 /xcortree=3134 /SigmaFactorBS="tttaaccagattatgcgtctatgccagatgttgttatAAATT GAAgcaaaattgaaagTGTGGTTAAATAGTGGTGAAtgaagggataacggttgaagtg a" /listShort="ypqE, yprA, yprB, S840, S839, cotD" /listLong="ypsA, gpsB, rnpB, ypsC, S838, yptA, S837, ypvA" /label="promotor_-35" promotor_-35 2006934..2006943 /Source="Nicolas_upshift_promotors" /id="U1746" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1340 /SigmaFactorBS="aaccacactttcaattttgcttcaaTTTATAACAAcatctgg catagaCGCATAATCTGGTTAAAAAAggcggtggcgatattggaattccatgatgaca a" /listShort="ypqA, S841" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2006957..2006976 /Source="Nicolas_upshift_promotors" /id="U1746" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1340 /SigmaFactorBS="aaccacactttcaattttgcttcaaTTTATAACAAcatctgg catagaCGCATAATCTGGTTAAAAAAggcggtggcgatattggaattccatgatgaca a" /listShort="ypqA, S841" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2006969 /Source="Nicolas_upshifts" /id="U1746" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1340 /SigmaFactorBS="aaccacactttcaattttgcttcaaTTTATAACAAcatctgg catagaCGCATAATCTGGTTAAAAAAggcggtggcgatattggaattccatgatgaca a" /listShort="ypqA, S841" /GFF_Attribute="listLong" /label="upshifts" CDS 2006990..2007409 /gene="ypqA" /locus_tag="BSU_22240" /old_locus_tag="BSU22240" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative chaperone" /protein_id="NP_390106.1" /db_xref="EnsemblGenomes-Gn:BSU22240" /db_xref="EnsemblGenomes-Tr:CAB14141" /db_xref="InterPro:IPR008978" /db_xref="SubtiList:BG11449" /db_xref="UniProtKB/Swiss-Prot:P50836" /translation="MEFHDDKKNELQKKEEIITEAIDTLFQSSAFGNLINGFQNLINS SLKDVQTTIHVRERDTGLYIDITIPATFRDGEIVVDVKSRYLHVTLQEKQKHQNEATF TSMTRTVQLPYEVRQEDMETSWNEQTMTLFFPKNKHE*" /label="ypqA CDS" gene 2006990..2007409 /gene="ypqA" /locus_tag="BSU_22240" /old_locus_tag="BSU22240" /label="ypqA gene" S_feature 2007410..2007560 /Source="Nicolas_S_feature" /locus_tag="new_2337997_2338147" /HighExp="S6, S8, S7, BT, S5, B36, B60, Pyr, G/S, nit" /AntisenseName="yppG" /AntisenseCor="0.95679380325708796" /AntisenseRegPval="-144.5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S841" CDS complement(2007430..2007807) /gene="yppG" /locus_tag="BSU_22250" /old_locus_tag="BSU22250" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22882546; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative spore coat protein; methionine-glutamine-rich protein" /protein_id="NP_390107.1" /db_xref="EnsemblGenomes-Gn:BSU22250" /db_xref="EnsemblGenomes-Tr:CAB14142" /db_xref="InterPro:IPR025555" /db_xref="SubtiList:BG11448" /db_xref="UniProtKB/Swiss-Prot:P50835" /translation="MNGSSRSYPRQMGYYYPQHMQGYYQQAAPGYLEQQLPQQHYGQQ DYYQPYAPIQPMPMQPPVFSNPYPIPRPNQQQPSQFQSIMSQFKKANGQFDFNKMMDT TGQVMSAMNQVGSLIKGFTSFFK*" /label="yppG CDS" gene complement(2007430..2007807) /gene="yppG" /locus_tag="BSU_22250" /old_locus_tag="BSU22250" /label="yppG gene" downshifts complement(2007463) /Source="Nicolas_upshifts" /id="D1167" /incds=0 /nref=10 /ntot=43 /MaxReadThrough="3.01854" /MaxDrop="4.7006" /score="0.85617333" /energy="-12.8" /TU="U1747" /idTUdmin="U1747" /TUdmin="-286" /isTUend="FALSE" /label="downshifts" S_feature 2007805..2007950 /Source="Nicolas_S_feature" /locus_tag="new_2338392_2338537" /HighExp="S6, S8, S7, BT, S5, B36, B60, Pyr, G/S, C30" /AntisenseName="yppG" /AntisenseCor="0.96504903995490698" /AntisenseRegPval="-156.6" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S842" promotor_-10 complement(2007837..2007855) /Source="Nicolas_upshift_promotors" /id="U1747" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1321 /SigmaFactorBS="aactttcgacacaatttgacaaatgctaatcatcacttGTGA CACAAAcaatagaagtcatTCATACATATATAGAAGAGaaatatgttgtgtttagggg g" /listShort="yppG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2007856) /Source="Nicolas_upshifts" /id="U1747" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1321 /SigmaFactorBS="aactttcgacacaatttgacaaatgctaatcatcacttGTGA CACAAAcaatagaagtcatTCATACATATATAGAAGAGaaatatgttgtgtttagggg g" /listShort="yppG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2007869..2007878) /Source="Nicolas_upshift_promotors" /id="U1747" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1321 /SigmaFactorBS="aactttcgacacaatttgacaaatgctaatcatcacttGTGA CACAAAcaatagaagtcatTCATACATATATAGAAGAGaaatatgttgtgtttagggg g" /listShort="yppG" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 2007951..2007970 /Source="Nicolas_upshift_promotors" /id="U1748" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.896103896103896" /psig="0.994005994005994" /xcortree=2721 /SigmaFactorBS="catttgtcaaattgtgtcgaaagtttaaattttttaaaaaca gaaaaaagtcgaatcatTATGGTACCATATTTTCAATacagatgagaggggatgcacc a" /listShort="yppF" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2007952 /Source="Nicolas_upshifts" /id="U1748" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.896103896103896" /psig="0.994005994005994" /xcortree=2721 /SigmaFactorBS="catttgtcaaattgtgtcgaaagtttaaattttttaaaaaca gaaaaaagtcgaatcatTATGGTACCATATTTTCAATacagatgagaggggatgcacc a" /listShort="yppF" /GFF_Attribute="listLong" /label="upshifts" CDS 2007995..2008183 /gene="yppF" /locus_tag="BSU_22260" /old_locus_tag="BSU22260" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735, 22882546; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative sporulation protein" /protein_id="NP_390108.1" /db_xref="EnsemblGenomes-Gn:BSU22260" /db_xref="EnsemblGenomes-Tr:CAB14143" /db_xref="InterPro:IPR025553" /db_xref="SubtiList:BG11447" /db_xref="UniProtKB/Swiss-Prot:P50834" /translation="MNVSYLSKRFAEMKKYETDCMNKLMDFAKFLYIQGHLSITEFRN SMKVLEANGAESPAYEMN*" /label="yppF CDS" gene 2007995..2008183 /gene="yppF" /locus_tag="BSU_22260" /old_locus_tag="BSU22260" /label="yppF gene" downshifts 2008199 /Source="Nicolas_upshifts" /id="D1168" /incds=0 /nref=112 /ntot=242 /MaxReadThrough="3.3677" /MaxDrop="5.69944" /score="0.283992322" /energy="-8.5" /TU="U1748" /idTUdmin="U1748" /TUdmin="-200" /isTUend="FALSE" /label="downshifts" CDS complement(2008222..2008593) /gene="yppE" /locus_tag="BSU_22270" /old_locus_tag="BSU22270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390109.1" /db_xref="EnsemblGenomes-Gn:BSU22270" /db_xref="EnsemblGenomes-Tr:CAB14144" /db_xref="InterPro:IPR014913" /db_xref="InterPro:IPR023351" /db_xref="PDB:2HFI" /db_xref="PDB:2IM8" /db_xref="SubtiList:BG11446" /db_xref="UniProtKB/Swiss-Prot:P50833" /translation="MLSQTLLEMTEQMIEVAEKGADRYQEGKNSNHSYDFFETIKPAV EENDELAARWAEGALELIKVRRPKYVHKEQIEAVKDNFLELVLQSYVHHIHKKRFKDI TESVLYTLHAVKDEIAREDSR*" /label="yppE CDS" gene complement(2008222..2008593) /gene="yppE" /locus_tag="BSU_22270" /old_locus_tag="BSU22270" /label="yppE gene" downshifts complement(2008255) /Source="Nicolas_upshifts" /id="D1169" /incds=0 /nref=158 /ntot=245 /MaxReadThrough="1.04225" /MaxDrop="5.78413" /score="-2.77698308" /energy="-10.3" /TU="NA" /idTUdmin="U1749" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2008605..2008624) /Source="Nicolas_upshift_promotors" /id="U1749" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2155 /SigmaFactorBS="acacaggtatgcgtttgagaaggtataccgcatcggCTGAAT ttgtgagtgaaaTTTGGTACGATAGGCATTGAggtgaaagatattgctatcacaaact t" /listShort="yppE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2008618) /Source="Nicolas_upshifts" /id="U1749" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2155 /SigmaFactorBS="acacaggtatgcgtttgagaaggtataccgcatcggCTGAAT ttgtgagtgaaaTTTGGTACGATAGGCATTGAggtgaaagatattgctatcacaaact t" /listShort="yppE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2008637..2008642) /Source="Nicolas_upshift_promotors" /id="U1749" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2155 /SigmaFactorBS="acacaggtatgcgtttgagaaggtataccgcatcggCTGAAT ttgtgagtgaaaTTTGGTACGATAGGCATTGAggtgaaagatattgctatcacaaact t" /listShort="yppE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2008639..2008884) /gene="yppD" /locus_tag="BSU_22280" /old_locus_tag="BSU22280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15687200; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative sporulation protein" /protein_id="NP_390110.1" /db_xref="EnsemblGenomes-Gn:BSU22280" /db_xref="EnsemblGenomes-Tr:CAB14145" /db_xref="InterPro:IPR020252" /db_xref="SubtiList:BG11445" /db_xref="UniProtKB/Swiss-Prot:P50832" /translation="MSGYVCKTDILRMLSDIEDELTRAEQSLNHSVNALEAEMRETEN DRLSVLEEEIIDLHICINELYQSPEHRYAFEKVYRIG*" /label="yppD CDS" gene complement(2008639..2008884) /gene="yppD" /locus_tag="BSU_22280" /old_locus_tag="BSU22280" /label="yppD gene" promotor_-10 complement(2008910..2008928) /Source="Nicolas_upshift_promotors" /id="U1750" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=446 /SigmaFactorBS="gcgatttgcttctagttttgtcatgagGAAGGAAAGagcctt gagagCAAAGAATGTTAACCGGGAgagacaaggaaagggaggtacacgaatgtccggt t" /listShort="yppD, yppE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2008915) /Source="Nicolas_upshifts" /id="U1750" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=446 /SigmaFactorBS="gcgatttgcttctagttttgtcatgagGAAGGAAAGagcctt gagagCAAAGAATGTTAACCGGGAgagacaaggaaagggaggtacacgaatgtccggt t" /listShort="yppD, yppE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2008940..2008948) /Source="Nicolas_upshift_promotors" /id="U1750" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=446 /SigmaFactorBS="gcgatttgcttctagttttgtcatgagGAAGGAAAGagcctt gagagCAAAGAATGTTAACCGGGAgagacaaggaaagggaggtacacgaatgtccggt t" /listShort="yppD, yppE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2009034..2009040 /Source="Nicolas_upshift_promotors" /id="U1751" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=860 /SigmaFactorBS="ctgaagttttcgacaaaaacacccgcaaaaatTGTATGAtcc tcctcattaatGCAAACGATACTtgtgaggaggtgccgtatgaaaacaagaccgaaaa a" /listShort="sspM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2009055..2009066 /Source="Nicolas_upshift_promotors" /id="U1751" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=860 /SigmaFactorBS="ctgaagttttcgacaaaaacacccgcaaaaatTGTATGAtcc tcctcattaatGCAAACGATACTtgtgaggaggtgccgtatgaaaacaagaccgaaaa a" /listShort="sspM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2009062 /Source="Nicolas_upshifts" /id="U1751" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=860 /SigmaFactorBS="ctgaagttttcgacaaaaacacccgcaaaaatTGTATGAtcc tcctcattaatGCAAACGATACTtgtgaggaggtgccgtatgaaaacaagaccgaaaa a" /listShort="sspM" /GFF_Attribute="listLong" /label="upshifts" CDS 2009083..2009187 /gene="sspM" /locus_tag="BSU_22290" /old_locus_tag="BSU22290" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10806362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10806362; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="YP_054585.1" /db_xref="EnsemblGenomes-Gn:BSU22290" /db_xref="EnsemblGenomes-Tr:CAE01459" /db_xref="GOA:Q7WY65" /db_xref="SubtiList:BG14177" /db_xref="UniProtKB/Swiss-Prot:Q7WY65" /translation="MKTRPKKAGQQKKTESKAIDSLDKKLGGPNRPST*" /label="sspM CDS" gene 2009083..2009187 /gene="sspM" /locus_tag="BSU_22290" /old_locus_tag="BSU22290" /label="sspM gene" downshifts 2009169 /Source="Nicolas_upshifts" /id="D1170" /incds=0 /nref=31 /ntot=49 /MaxReadThrough="1.6498" /MaxDrop="6.01285" /score="0.283992322" /energy="-8.5" /TU="NA" /idTUdmin="U1751" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2009212..2010174) /gene="yppC" /locus_tag="BSU_22300" /old_locus_tag="BSU22300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390111.1" /db_xref="EnsemblGenomes-Gn:BSU22300" /db_xref="EnsemblGenomes-Tr:CAB14146" /db_xref="InterPro:IPR019658" /db_xref="SubtiList:BG10952" /db_xref="UniProtKB/Swiss-Prot:P39791" /translation="MNVQEQQAIRKLLSRIERQTKMKNADNISRTNAYKAFYDRHPEI KWSLLASFVSRNAGWSMTDLKGSLFQLGLRERQQKWFFLAYERANWLIFSDAYPQLLL YHWSKRVGKPLFHLLHVFGVSQFMSEEWTRFWHERNTERLMYALIINEQNTIQTPIIQ NPSFKKNVFDTIPFYLSDWFHFNTVIFPSSNGFFYGISVKRFSKAEERIRLGKQLSQL LFKPELFSSFYHFLHTVPHTGSRFDMEKMIGITKRTSPMLRTCYPELIHSLDGTKTDW FHGKIKKTFFRREELPKQIELTDWYLHKKRQLHALFAVEQWLKK*" /label="yppC CDS" gene complement(2009212..2010174) /gene="yppC" /locus_tag="BSU_22300" /old_locus_tag="BSU22300" /label="yppC gene" promotor_-35 2009342..2009351 /Source="Nicolas_upshift_promotors" /id="U1752" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1658 /SigmaFactorBS="aattcctcgcgcctaaagaacgttttctttatctttccaTGA AACCAATctgttttcgttCCGTCTAATGAGTGGAttaactcagggtagcatgtcctta g" /listShort="S843, S844, recU, ponA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2009363..2009378 /Source="Nicolas_upshift_promotors" /id="U1752" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1658 /SigmaFactorBS="aattcctcgcgcctaaagaacgttttctttatctttccaTGA AACCAATctgttttcgttCCGTCTAATGAGTGGAttaactcagggtagcatgtcctta g" /listShort="S843, S844, recU, ponA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2009363 /Source="Nicolas_upshifts" /id="U1752" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1658 /SigmaFactorBS="aattcctcgcgcctaaagaacgttttctttatctttccaTGA AACCAATctgttttcgttCCGTCTAATGAGTGGAttaactcagggtagcatgtcctta g" /listShort="S843, S844, recU, ponA" /GFF_Attribute="listLong" /label="upshifts" S_feature 2009367..2009702 /Source="Nicolas_S_feature" /locus_tag="new_2339954_2340289" /HighExp="T1.0H, T0.30H, T1.30H, H2O2, Paraq, LBGstat, T2.0H, T-0.40H, Salt, T2.30H" /AntisenseName="yppC" /AntisenseCor="-0.27690969451148201" /AntisenseRegPval="-5.4" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S843" promotor_-35 2009673..2009677 /Source="Nicolas_upshift_promotors" /id="U1753" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.965034965034965" /psig=1 /xcortree=2511 /SigmaFactorBS="acttaaataaaaaggaatcgtgtcaaaaaCATTCtttttaaa cgaaggaTTTTGTATAATAGGTGTTTGgatagtgttttgttcatttataatgagggca t" /listShort="S844, recU, ponA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2009693..2009712 /Source="Nicolas_upshift_promotors" /id="U1753" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.965034965034965" /psig=1 /xcortree=2511 /SigmaFactorBS="acttaaataaaaaggaatcgtgtcaaaaaCATTCtttttaaa cgaaggaTTTTGTATAATAGGTGTTTGgatagtgttttgttcatttataatgagggca t" /listShort="S844, recU, ponA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2009704..2010214 /Source="Nicolas_S_feature" /locus_tag="new_2340291_2340801" /HighExp="LBGstat, T1.0H, T1.30H, H2O2, T0.30H, Paraq, T2.0H, C30, G135, G180" /AntisenseName="yppC" /AntisenseCor="-0.312791370178301" /AntisenseRegPval="-6.8" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S844" upshifts 2009704 /Source="Nicolas_upshifts" /id="U1753" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.965034965034965" /psig=1 /xcortree=2511 /SigmaFactorBS="acttaaataaaaaggaatcgtgtcaaaaaCATTCtttttaaa cgaaggaTTTTGTATAATAGGTGTTTGgatagtgttttgttcatttataatgagggca t" /listShort="S844, recU, ponA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2010175..2010631) /Source="Nicolas_S_feature" /locus_tag="new_2340762_2341218_c" /HighExp="S8, S6, S7, S5, C30, G135, S4, BT, G180, Fru" /AntisenseName="recU" /AntisenseCor="-0.34780203121991599" /AntisenseRegPval="-8.3000000000000007" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S845" CDS 2010215..2010835 /gene="recU" /locus_tag="BSU_22310" /old_locus_tag="BSU22310" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:14701911, 15317759, 16020779, 16024744, 19433509, 19542287, 20735784, 21600217, 27903910" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14701911, 15317759, 16020779, 16024744, 19433509, 19542287, 20735784, 21600217, 27903910; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Holliday junction resolvase" /protein_id="NP_390112.1" /db_xref="EnsemblGenomes-Gn:BSU22310" /db_xref="EnsemblGenomes-Tr:CAB14147" /db_xref="GOA:P39792" /db_xref="InterPro:IPR004612" /db_xref="InterPro:IPR011335" /db_xref="PDB:1RZN" /db_xref="PDB:1ZP7" /db_xref="PDB:5FDK" /db_xref="SubtiList:BG10953" /db_xref="UniProtKB/Swiss-Prot:P39792" /translation="MIRYPNGKTFQPKHSVSSQNSQKRAPSYSNRGMTLEDDLNETNK YYLTNQIAVIHKKPTPVQIVNVHYPKRSAAVIKEAYFKQSSTTDYNGIYKGRYIDFEA KETKNKTSFPLQNFHDHQIEHMKQVKAQDGICFVIISAFDQVYFLEADKLFYFWDRKE KNGRKSIRKDELEETAYPISLGYAPRIDYISIIEQLYFSPSSGAKG*" /label="recU CDS" gene 2010215..2010835 /gene="recU" /locus_tag="BSU_22310" /old_locus_tag="BSU22310" /label="recU gene" promotor_-10 complement(2010620..2010631) /Source="Nicolas_upshift_promotors" /id="U1754" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=893 /SigmaFactorBS="ttttctgtcccagaaataaaacagcttatcggcttccaaAAA ATAAacctggtcgaaagcGGATATAATAACaaaacaaataccgtcttgagcctttacc t" /listShort="S845" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2010631) /Source="Nicolas_upshifts" /id="U1754" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=893 /SigmaFactorBS="ttttctgtcccagaaataaaacagcttatcggcttccaaAAA ATAAacctggtcgaaagcGGATATAATAACaaaacaaataccgtcttgagcctttacc t" /listShort="S845" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2010646..2010652) /Source="Nicolas_upshift_promotors" /id="U1754" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=893 /SigmaFactorBS="ttttctgtcccagaaataaaacagcttatcggcttccaaAAA ATAAacctggtcgaaagcGGATATAATAACaaaacaaataccgtcttgagcctttacc t" /listShort="S845" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2010857..2013601 /gene="ponA" /locus_tag="BSU_22320" /old_locus_tag="BSU22320" /EC_number="2.4.1.129" /function="16.9: Replicate" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10322023, 10692371, 12562814, 15262952, 18266856, 25355936, 27852437" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10322023, 10692371, 12562814, 15262952, 18266856, 25355936, 27852437; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptidoglycan glycosyltransferase (penicillin-binding proteins 1A and 1B)" /protein_id="NP_390113.1" /db_xref="EnsemblGenomes-Gn:BSU22320" /db_xref="EnsemblGenomes-Tr:CAB14148" /db_xref="GOA:P39793" /db_xref="InterPro:IPR001264" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR003961" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR023346" /db_xref="InterPro:IPR036116" /db_xref="InterPro:IPR036950" /db_xref="SubtiList:BG10954" /db_xref="UniProtKB/Swiss-Prot:P39793" /translation="MSDQFNSREARRKANSKSSPSPKKGKKRKKGGLFKKTLFTLLIL FVLGVVGGAVTFAVMVSDAPSLDESKLKTPYSSTIYDKNGKEIAEVGAEKRTYVSIDE IPDVVKEAFIATEDARFYEHHGIDPVRIGGALVANFKDGFGAEGGSTITQQVVKNSLL SHQKTLKRKVQEVWLSIQLERNYSKDEILEMYLNRIYFSPRAYGIGKAAEEFFGVTDL SKLTVEQAATLAGMPQSPTAYNPVKNPDKAEKRRNIVLSLMKKQGFISDSQYNKAKKV AVKDEGVVSQKEYEKASTNKYSAFVEEVMKEIDEKSDVDPSADGLKIYTTLDTKAQDK LDELMDGDTVGFTEGMQGGVTLLDTKNGEVRAIGAGRNQPVGGFNYATQTKAQPGSTI KPILDYGPVIENKKWSTYEQIDDSAYTYSNGKPIRDWDRKYLGPISMRYALAQSRNIP ALKAFQAVGKDTAVDFANGLGLGLTKDNVTEAYSIGGFGGNDGVSPLTMAGAYSAFGN NGTYNEPHFVKSIEFNDGTKLDLTPKSKSAMSDYTAFMITDMLKTAVKTGTGQLAQVP GVEVAGKTGTTNFDDNEVKRYNIASGGARDSWFVGYTPQYTAAVWTGMGENEAGKKSL SAEEQKVAKRIFAQLIADVDDGSGSFEKPDSVVEATVEKGSNPAKLAGPNTPSDKKLT EYFVKGTAPSTVSKTYEKEEKEETAKLSGLNVKYDKDNQSLTLSWNYDGDATFAVKQS VDGGSYSEIQNSSAKEAVISGVQPGSVYKFEVTAVSDDGKSTASTSYEVPKAEDDEDK KDQQQTDDEKQDDEKTQDDTQTDDSQKDDGQTDQDQTDDSTNDQDKKQDNTNTNPSDN NNQDQSNDNDNDNSNNQDTSDGDSNSGKNDSTGSDTNKNKTDTSNKTQTNSSSIEKTN *" /label="ponA CDS" gene 2010857..2013601 /gene="ponA" /locus_tag="BSU_22320" /old_locus_tag="BSU22320" /label="ponA gene" downshifts complement(2013271) /Source="Nicolas_upshifts" /id="D1171" /incds=1 /nref=1 /ntot=77 /MaxReadThrough="1.95969" /MaxDrop="2.87717" /score="24.9960782" /energy="-11.3" /TU="NA" /idTUdmin="U1755" /TUdmin=418 /isTUend="FALSE" /label="downshifts" downshifts 2013587 /Source="Nicolas_upshifts" /id="D1172" /incds=0 /nref=243 /ntot=302 /MaxReadThrough="1.61976" /MaxDrop="7.42523" /score="24.2831363" /energy="-14.6" /TU="U1753" /idTUdmin="U1752" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(2013677..2014171) /gene="ypoC" /locus_tag="BSU_22330" /old_locus_tag="BSU22330" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390114.1" /db_xref="EnsemblGenomes-Gn:BSU22330" /db_xref="EnsemblGenomes-Tr:CAB14149" /db_xref="SubtiList:BG10955" /db_xref="UniProtKB/Swiss-Prot:P39789" /translation="MTQAKEVLASYEQYLRSLGQKSSSDMKKTLQTNPVYFDFCTELQ GDLPWEDSGKYVPLLFEVWDDIKASLLPVFQTRKSRCDQNEMLKGIVCLLASLHWTAG EPVKSLDWQELREKSYPAKPINWAERVEFILLKPTQYHCFIQLDELITEMKKHFYKYH AMNR*" /label="ypoC CDS" gene complement(2013677..2014171) /gene="ypoC" /locus_tag="BSU_22330" /old_locus_tag="BSU22330" /label="ypoC gene" downshifts complement(2013690) /Source="Nicolas_upshifts" /id="D1173" /incds=0 /nref=116 /ntot=222 /MaxReadThrough="2.50883" /MaxDrop="5.43593" /score="29.5358766" /energy="-11.6" /TU="NA" /idTUdmin="U1755" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2014168..2014827) /gene="nth" /locus_tag="BSU_22340" /old_locus_tag="BSU22340" /EC_number="4.2.99.18" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9808040, 11160880, 12682299, 21954439, 24914186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9808040, 11160880, 12682299, 21954439, 24914186; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endonuclease III, apurinic apyrimidic DNA lyase" /protein_id="NP_390115.1" /db_xref="EnsemblGenomes-Gn:BSU22340" /db_xref="EnsemblGenomes-Tr:CAB14150" /db_xref="GOA:P39788" /db_xref="InterPro:IPR000445" /db_xref="InterPro:IPR003265" /db_xref="InterPro:IPR003651" /db_xref="InterPro:IPR004035" /db_xref="InterPro:IPR004036" /db_xref="InterPro:IPR005759" /db_xref="InterPro:IPR011257" /db_xref="InterPro:IPR023170" /db_xref="SubtiList:BG10956" /db_xref="UniProtKB/Swiss-Prot:P39788" /translation="MLNLKQIEFCLDKIGDMFPHAECELVHSNPFELVVAVALSAQCT DALVNRVTKTLFQKYKRPEDYLAVPLEELQQDIKSIGLYRNKAKNIQKLSKMIIEDYG GEVPRDRDELVKLPGVGRKTANVVVSVAFGVPAIAVDTHVERVSKRLGICRWKDSVLE VEKTLMRKVPKEDWSVTHHRLIFFGRYHCKAQSPRCAECPLLSLCREGQKRDKKGLVK R*" /label="nth CDS" gene complement(2014168..2014827) /gene="nth" /locus_tag="BSU_22340" /old_locus_tag="BSU22340" /label="nth gene" CDS complement(2014846..2015544) /gene="dnaD" /locus_tag="BSU_22350" /old_locus_tag="BSU22350" /function="16.9: Replicate" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11222620, 12682299, 15556628, 15686560, 16002087, 16677303, 16855238, 17277452, 18206906, 21954439, 22821970, 23909787" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11222620, 12682299, 15556628, 15686560, 16002087, 16677303, 16855238, 17277452, 18206906, 21954439, 22821970, 23909787; Product type f: factor" /codon_start=1 /transl_table=11 /product="DNA-remodelling primosomal protein" /protein_id="NP_390116.1" /db_xref="EnsemblGenomes-Gn:BSU22350" /db_xref="EnsemblGenomes-Tr:CAB14151" /db_xref="GOA:P39787" /db_xref="InterPro:IPR006343" /db_xref="InterPro:IPR034829" /db_xref="PDB:2V79" /db_xref="SubtiList:BG10957" /db_xref="UniProtKB/Swiss-Prot:P39787" /translation="MKKQQFIDMQEQGTSTIPNLLLTHYKQLGLNETELILLLKIKMH LEKGSYFPTPNQLQEGMSISVEECTNRLRMFIQKGFLFIEECEDQNGIKFEKYSLQPL WGKLYEYIQLAQNQTQERKAEGEQKSLYTIFEEEFARPLSPLECETLAIWQDQDQHDA QLIKHALKEAVLSGKLSFRYIDRILFEWKKNGLKTVEQAKIHSQKFRRVQAKQNEPQK EYKRQVPFYNWLEQ*" /label="dnaD CDS" gene complement(2014846..2015544) /gene="dnaD" /locus_tag="BSU_22350" /old_locus_tag="BSU22350" /label="dnaD gene" S_feature complement(2015545..2015636) /Source="Nicolas_S_feature" /locus_tag="new_2346132_2346223_c" /HighExp="LoTm, G180, Cold, G135, LBGstat, G150, C30, Etha, Oxctl, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="0.999, 0.994, 0.85, 1" /TUlongSig="SigWXY, SigA, SigA" /TUlongPSig="1, 1, 0.995" /label="S846" CDS complement(2015637..2016929) /gene="asnS" /locus_tag="BSU_22360" /old_locus_tag="BSU22360" /EC_number="6.1.1.22" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 26804570; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="asparaginyl-tRNA synthetase" /protein_id="NP_390117.1" /db_xref="EnsemblGenomes-Gn:BSU22360" /db_xref="EnsemblGenomes-Tr:CAB14152" /db_xref="GOA:P39772" /db_xref="InterPro:IPR002312" /db_xref="InterPro:IPR004364" /db_xref="InterPro:IPR004365" /db_xref="InterPro:IPR004522" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR012340" /db_xref="SubtiList:BG10958" /db_xref="UniProtKB/Swiss-Prot:P39772" /translation="MKTTINQVYKHVGEEVTIGAWVANKRSSGKIAFLQLRDGTGFIQ GVVVKAEVEESIFQTAKSVTQETSLYIKGIVKEDERSPLGYELAVTDIEVIHEATDYP ITPKEHGTEFLMDHRHLWLRSKRQHAIMKIRNEIIRATYEFFNNEGFVKVDPPILTGS APEGTTELFATKYFDEDAYLSQSGQLYMEAAAMALGKVFSFGPTFRAEKSKTKRHLIE FWMIEPEMAFVEFEENLQVQENYVSFIVQSVLKNCKIELNTLGRDTSKLEQIKAPFPR ITYDEAIEFLKEKGFDDIEWGDDFGAPHETAIAEHYDKPVFITRYPTSLKPFYMQPAS DREDVVLCADLIAPEGYGEIIGGSERIHDMELLESRLKEHGLDSDAYKWYAELRKYGS VPHSGFGLGLERTVAWISGAPHVRETIPFPRLLNRLYP*" /label="asnS CDS" gene complement(2015637..2016929) /gene="asnS" /locus_tag="BSU_22360" /old_locus_tag="BSU22360" /label="asnS gene" S_feature complement(2016930..2016991) /Source="Nicolas_S_feature" /locus_tag="new_2347517_2347578_c" /HighExp="LBGexp, dia0, Lbexp, G150, G180, LPh, C30, Oxctl, LBGtran, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="0.999, 0.994, 0.85, 1" /TUlongSig="SigWXY, SigA, SigA" /TUlongPSig="1, 1, 0.995" /label="S847" promotor_-10 complement(2016991..2017010) /Source="Nicolas_upshift_promotors" /id="U1755" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=2680 /SigmaFactorBS="gaaaagccgctttttatctGCATTGACccggttagttaagaG CGGGTATAATAAAGTGATGataaaagagttcgcggggcaatgagcttccgaatgtctt t" /listShort="S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2016991) /Source="Nicolas_upshifts" /id="U1755" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=2680 /SigmaFactorBS="gaaaagccgctttttatctGCATTGACccggttagttaagaG CGGGTATAATAAAGTGATGataaaagagttcgcggggcaatgagcttccgaatgtctt t" /listShort="S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2017025..2017032) /Source="Nicolas_upshift_promotors" /id="U1755" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=2680 /SigmaFactorBS="gaaaagccgctttttatctGCATTGACccggttagttaagaG CGGGTATAATAAAGTGATGataaaagagttcgcggggcaatgagcttccgaatgtctt t" /listShort="S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2017073..2018254) /gene="aspB" /locus_tag="BSU_22370" /old_locus_tag="BSU22370" /EC_number="2.6.1.1" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:418816, 12670965, 22740702" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 418816, 12670965, 22740702; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="anabolic oxaloacetate / glutamate aminotransferase" /protein_id="NP_390118.1" /db_xref="EnsemblGenomes-Gn:BSU22370" /db_xref="EnsemblGenomes-Tr:CAB14153" /db_xref="GOA:P53001" /db_xref="InterPro:IPR004838" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG11513" /db_xref="UniProtKB/Swiss-Prot:P53001" /translation="MKLAKRVSALTPSTTLAITAKAKELKAAGHDVIGLGAGEPDFNT PQHIIDAAVRSMNEGHTKYTPSGGLAELKNSIAEKFKRDQNIEYKPSQIIVCTGAKHA LYTLFQVILDEEDEVIIPTPYWVSYPEQVKLAGGKPVYVEGLEENHFKISPEQLKNAI TEKTKAIVINSPSNPTGVMYTEEELSALGEVCLEHDILIVSDEIYEKLTYGGKKHVSI AQLSDRLKEQTVIINGVSKSHSMTGWRIGYAAGSEDIIKAMTNLASHSTSNPTSIAQY GAIAAYNGPSEPLEEMREAFEHRLNTIYAKLIEIPGFSCVKPEGAFYLFPNAKEAAQS CGFKDVDEFVKALLEEEKVAIVPGSGFGSPENVRLSYATSLDLLEEAIERIKRFVEKH S*" /label="aspB CDS" gene complement(2017073..2018254) /gene="aspB" /locus_tag="BSU_22370" /old_locus_tag="BSU22370" /label="aspB gene" downshifts complement(2017077) /Source="Nicolas_upshifts" /id="D1174" /incds=0 /nref=48 /ntot=196 /MaxReadThrough="6.37268" /MaxDrop="4.0831" /score="5.04709675" /energy="-9.3" /TU="U1756,U1758,U1760,U1761,U1762" /idTUdmin="U1760" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" CDS complement(2018277..2018762) /gene="tseB" /locus_tag="BSU_22380" /old_locus_tag="BSU22380" /experiment="publication(s) with functional evidences, PMID:25954268" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25954268; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="suppressor of tetracyclin sensitivity of an ezrAmutant" /protein_id="NP_390119.1" /db_xref="EnsemblGenomes-Gn:BSU22380" /db_xref="EnsemblGenomes-Tr:CAB14154" /db_xref="GOA:P54396" /db_xref="InterPro:IPR025711" /db_xref="PDB:2GU3" /db_xref="SubtiList:BG11502" /db_xref="UniProtKB/Swiss-Prot:P54396" /translation="MRKKALIFTVIFGIIFLAVLLVSASIYKSAMAQKEEGHEAAAAE AKKETDLAHVDQVETFVGKEKYYVVKGTDKKGTALYVWVPADKKAKILSKEAKEGISE DKAAKIIKDEGLVSKQKEVHLAREGNVLLWEVTYLDKEGQYSLSYVDFTTGKILKNIT P*" /label="tseB CDS" gene complement(2018277..2018762) /gene="tseB" /locus_tag="BSU_22380" /old_locus_tag="BSU22380" /label="tseB gene" promotor_-10 complement(2018710..2018729) /Source="Nicolas_upshift_promotors" /id="U1756" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.47952047952048" /psig="0.994005994005994" /xcortree=2324 /SigmaFactorBS="ccatttatcgtacgtaggtgagaagatgagaaaaaaagCATT AATAtttaccgtcattTTTGGTATTATTTTTTTAGCagtacttcttgtctcggcaagc a" /listShort="ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2018727) /Source="Nicolas_upshifts" /id="U1756" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.47952047952048" /psig="0.994005994005994" /xcortree=2324 /SigmaFactorBS="ccatttatcgtacgtaggtgagaagatgagaaaaaaagCATT AATAtttaccgtcattTTTGGTATTATTTTTTTAGCagtacttcttgtctcggcaagc a" /listShort="ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2018742..2018749) /Source="Nicolas_upshift_promotors" /id="U1756" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.47952047952048" /psig="0.994005994005994" /xcortree=2324 /SigmaFactorBS="ccatttatcgtacgtaggtgagaagatgagaaaaaaagCATT AATAtttaccgtcattTTTGGTATTATTTTTTTAGCagtacttcttgtctcggcaagc a" /listShort="ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2018771..2018941) /gene="ypmA" /locus_tag="BSU_22390" /old_locus_tag="BSU22390" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390120.1" /db_xref="EnsemblGenomes-Gn:BSU22390" /db_xref="EnsemblGenomes-Tr:CAB14155" /db_xref="InterPro:IPR012190" /db_xref="SubtiList:BG11501" /db_xref="UniProtKB/Swiss-Prot:P54395" /translation="MESKIEILSTINVEHSDDLYKIVDTLNRTLKRDNLMFGLALDEE NKNQAVFTIYRT*" /label="ypmA CDS" gene complement(2018771..2018941) /gene="ypmA" /locus_tag="BSU_22390" /old_locus_tag="BSU22390" /label="ypmA gene" S_feature complement(2018942..2019013) /Source="Nicolas_S_feature" /locus_tag="new_2349529_2349600_c" /HighExp="H2O2, T0.30H, T0.0H, dia15, T-0.40H, T-1.10H, G135, T1.0H, G180, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.136042" /TUshortSig="SigA, SigWXY, SigA, SigA, SigA" /TUshortPSig="0.85, 1, 1, 1, 0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S848" promotor_-35 2018975..2018981 /Source="Nicolas_upshift_promotors" /id="U1757" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=823 /SigmaFactorBS="ttttcatcctccagtttgaacaaatattgttaGTCATACtcc atttcaggacaCGCCATACTAGTatcacagagcgggaaatccgcttttaaataaaaca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2018996..2019015) /Source="Nicolas_upshift_promotors" /id="U1758" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.646353646353646" /psig="0.85014985014985" /xcortree=1587 /SigmaFactorBS="aagcggcttttgcggtgtgggagtaggatggtgtttTATTTA AaagcggatttcccgcTCTGTGATACTAGTATGGCGtgtcctgaaatggagtatgact a" /listShort="S848, ypmA, ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2018996..2019007 /Source="Nicolas_upshift_promotors" /id="U1757" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=823 /SigmaFactorBS="ttttcatcctccagtttgaacaaatattgttaGTCATACtcc atttcaggacaCGCCATACTAGTatcacagagcgggaaatccgcttttaaataaaaca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2019003..2019077 /Source="Nicolas_S_feature" /locus_tag="new_2349590_2349664" /HighExp="S8, S6, S5, S7, nit, BT, G/S, Pyr, C30, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S849" upshifts 2019003 /Source="Nicolas_upshifts" /id="U1757" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=823 /SigmaFactorBS="ttttcatcctccagtttgaacaaatattgttaGTCATACtcc atttcaggacaCGCCATACTAGTatcacagagcgggaaatccgcttttaaataaaaca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2019013) /Source="Nicolas_upshifts" /id="U1758" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.646353646353646" /psig="0.85014985014985" /xcortree=1587 /SigmaFactorBS="aagcggcttttgcggtgtgggagtaggatggtgtttTATTTA AaagcggatttcccgcTCTGTGATACTAGTATGGCGtgtcctgaaatggagtatgact a" /listShort="S848, ypmA, ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2019015..2019083) /Source="Nicolas_S_feature" /locus_tag="new_2349602_2349670_c" /HighExp="T0.30H, T1.0H, T-0.40H, T1.30H, T0.0H, Salt, H2O2, T-1.10H, Oxctl, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY, SigA, SigA, SigA" /TUshortPSig="1, 1, 1, 0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S850" promotor_-35 complement(2019031..2019037) /Source="Nicolas_upshift_promotors" /id="U1758" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.646353646353646" /psig="0.85014985014985" /xcortree=1587 /SigmaFactorBS="aagcggcttttgcggtgtgggagtaggatggtgtttTATTTA AaagcggatttcccgcTCTGTGATACTAGTATGGCGtgtcctgaaatggagtatgact a" /listShort="S848, ypmA, ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2019047 /Source="Nicolas_upshifts" /id="D1175" /incds=0 /nref=8 /ntot=26 /MaxReadThrough="0.48859" /MaxDrop="6.02806" /score="18.4569945" /energy="-8.4" /TU="NA" /idTUdmin="U1757" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2019084..2021879) /gene="dinG" /locus_tag="BSU_22400" /old_locus_tag="BSU22400" /EC_number="3.6.1.-" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8385320, 12060778, 17416902, 21546913, 22166102, 28527403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8385320, 12060778, 17416902, 21546913, 22166102, 28527403; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="damage inducible ATP-dependent 3'->5' nuclease" /protein_id="NP_390121.1" /db_xref="EnsemblGenomes-Gn:BSU22400" /db_xref="EnsemblGenomes-Tr:CAB14156" /db_xref="GOA:P54394" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR006054" /db_xref="InterPro:IPR006310" /db_xref="InterPro:IPR006555" /db_xref="InterPro:IPR006935" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR013520" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR014013" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG11515" /db_xref="UniProtKB/Swiss-Prot:P54394" /translation="MNKQRFVVIDVETTGNSPKKGDKIIQIAAVVIENGQITERFSKY INPNKSIPAFIEQLTGISNQMVENEQPFEAVAEEVFQLLDGAYFVAHNIHFDLGFVKY ELHKAGFQLPDCEVLDTVELSRIVFPGFEGYKLTELSEELQLRHDQPHRADSDAEVTG LIFLEILEKLRQLPYPTLKQLRRLSQHFISDLTHLLDMFINENRHTEIPGYTRFSSFS VREPEAIDVRINEDENFSFEIESWEAGNEKALSELMPGYEKRDGQMMMMREVADAFAN REHALIEAPPGIGKTIGYLIPAALFAKKSKKPVIISTYSTLLQQQILTKDLPIVQDLF PFPVTAAILKGQSHYLCLYKFEQVLHEEDDNYDAVLTKAQLLVWLTETNTGDVAELNL PSGGKLLWDRLAYDDDSYKRSRSEHVIGFYERAKQIAMRSDLVITNHSLLLTDEGSHK KRLPESGTFIIDEAHHFERAASEHLGKRATYIELHTKLSRIGTLKEQGLLKKMRQLFQ RNSLPVDSFFELEEWLQHVQAESDAFFSSVHSFVKRRKPKEDLNRLVFKVNKESQDKS WSILTDGAERLCSMLTHLQQLFEAQSSLMEKHLKGMKSKTVFLADEYQRSMKGLQHYC QTLQKLFFGSDDDEAVWIEIDAKGAKNAVAIYAQPLEPGELLADQFFARKNSVVLTSA TLTVEGSFQFMIERLGLSDFFPRTMRIESPFSYDERMQVMIPKEMKSIQDTGQPEFIQ DTARYIELMAKEKQPKILVLFTSHDMLKKVHQELKHNMSASGIQLLAQGITGGSPGKL MKTFKTSNQAILLGTNHFWEGVDFPGDELTTVMIVRLPFRSPDHPLHAAKCELARKKG KNPFQTVSLPEAVLTFRQGIGRLLRSAGDKGTIIILDRRIKTAGYGRLFLDALPTTSV SEMTDSELEAYVAGEKE*" /label="dinG CDS" gene complement(2019084..2021879) /gene="dinG" /locus_tag="BSU_22400" /old_locus_tag="BSU22400" /label="dinG gene" promotor_-35 2019552..2019556 /Source="Nicolas_upshift_promotors" /id="U1759" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.645354645354645" /psig="0.340659340659341" /xcortree=32 /SigmaFactorBS="ccgggacttccgcctgtaatcccttgtgccaagagctgaatg ccggaagcactcatgttATGCTtAAGCTcctggtgaacctttttcagcatatcatggg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2019553 /Source="Nicolas_upshifts" /id="U1759" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.645354645354645" /psig="0.340659340659341" /xcortree=32 /SigmaFactorBS="ccgggacttccgcctgtaatcccttgtgccaagagctgaatg ccggaagcactcatgttATGCTtAAGCTcctggtgaacctttttcagcatatcatggg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2019558..2019562 /Source="Nicolas_upshift_promotors" /id="U1759" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.645354645354645" /psig="0.340659340659341" /xcortree=32 /SigmaFactorBS="ccgggacttccgcctgtaatcccttgtgccaagagctgaatg ccggaagcactcatgttATGCTtAAGCTcctggtgaacctttttcagcatatcatggg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2020209..2020224) /Source="Nicolas_upshift_promotors" /id="U1760" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1683 /SigmaFactorBS="gctttctttagctctgtacattcttttgtcaaacgaaGAAAA CCTAAagaagacttaaaCCGTCTAGTGTTTAAGgtgaacaaagaaagccaggataaaa g" /listShort="S850, S848, ypmA, ypmB, aspB" /listLong="S847, asnS, S846, dnaD, nth, ypoC" /label="promotor_-10" upshifts complement(2020223) /Source="Nicolas_upshifts" /id="U1760" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1683 /SigmaFactorBS="gctttctttagctctgtacattcttttgtcaaacgaaGAAAA CCTAAagaagacttaaaCCGTCTAGTGTTTAAGgtgaacaaagaaagccaggataaaa g" /listShort="S850, S848, ypmA, ypmB, aspB" /listLong="S847, asnS, S846, dnaD, nth, ypoC" /label="upshifts" promotor_-35 complement(2020237..2020246) /Source="Nicolas_upshift_promotors" /id="U1760" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1683 /SigmaFactorBS="gctttctttagctctgtacattcttttgtcaaacgaaGAAAA CCTAAagaagacttaaaCCGTCTAGTGTTTAAGgtgaacaaagaaagccaggataaaa g" /listShort="S850, S848, ypmA, ypmB, aspB" /listLong="S847, asnS, S846, dnaD, nth, ypoC" /label="promotor_-35" S_feature complement(2021880..2022004) /Source="Nicolas_S_feature" /locus_tag="new_2352467_2352591_c" /HighExp="dia15, Diami, H2O2, Heat, LBGstat, C30, G180, G135, Oxctl, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S851" CDS complement(2022005..2022388) /gene="panD" /locus_tag="BSU_22410" /old_locus_tag="BSU22410" /EC_number="4.1.1.11" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9169598, 12600205, 15033515, 26762040" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9169598, 12600205, 15033515, 26762040; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aspartate 1-decarboxylase" /protein_id="NP_390122.1" /db_xref="EnsemblGenomes-Gn:BSU22410" /db_xref="EnsemblGenomes-Tr:CAB14157" /db_xref="GOA:P52999" /db_xref="InterPro:IPR003190" /db_xref="InterPro:IPR009010" /db_xref="SubtiList:BG11493" /db_xref="UniProtKB/Swiss-Prot:P52999" /translation="MYRTMMSGKLHRATVTEANLNYVGSITIDEDLIDAVGMLPNEKV QIVNNNNGARLETYIIPGKRGSGVICLNGAAARLVQEGDKVIIISYKMMSDQEAASHE PKVAVLNDQNKIEQMLGNEPARTIL*" /label="panD CDS" gene complement(2022005..2022388) /gene="panD" /locus_tag="BSU_22410" /old_locus_tag="BSU22410" /label="panD gene" CDS complement(2022390..2023250) /gene="panC" /locus_tag="BSU_22420" /old_locus_tag="BSU22420" /EC_number="6.3.2.1" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17175524, 7037743; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pantothenate synthetase" /protein_id="NP_390123.1" /db_xref="EnsemblGenomes-Gn:BSU22420" /db_xref="EnsemblGenomes-Tr:CAB14158" /db_xref="GOA:P52998" /db_xref="InterPro:IPR003721" /db_xref="InterPro:IPR004821" /db_xref="InterPro:IPR014729" /db_xref="SubtiList:BG11520" /db_xref="UniProtKB/Swiss-Prot:P52998" /translation="MRQITDISQLKEAIKQYHSEGKSIGFVPTMGFLHEGHLTLADKA RQENDAVIMSIFVNPAQFGPNEDFEAYPRDIERDAALAENAGVDILFTPDAHDMYPGE KNVTIHVERRTDVLCGRSREGHFDGVAIVLTKLFNLVKPTRAYFGLKDAQQVAVVDGL ISDFFMDIELVPVDTVREEDGLAKSSRNVYLTAEERKEAPKLYRALQTSAELVQAGER DPEAVIKAAKDIIETTSGTIDYVELYSYPELEPVNEIAGKMILAVAVAFSKARLIDNI IIDIREMERI*" /label="panC CDS" gene complement(2022390..2023250) /gene="panC" /locus_tag="BSU_22420" /old_locus_tag="BSU22420" /label="panC gene" CDS complement(2023252..2024085) /gene="panB" /locus_tag="BSU_22430" /old_locus_tag="BSU22430" /EC_number="2.1.2.11" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1844812, 8096212; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ketopantoate hydroxymethyltransferase" /protein_id="NP_390124.1" /db_xref="EnsemblGenomes-Gn:BSU22430" /db_xref="EnsemblGenomes-Tr:CAB14159" /db_xref="GOA:P52996" /db_xref="InterPro:IPR003700" /db_xref="InterPro:IPR015813" /db_xref="SubtiList:BG11519" /db_xref="UniProtKB/Swiss-Prot:P52996" /translation="MKTKLDFLKMKESEEPIVMLTAYDYPAAKLAEQAGVDMILVGDS LGMVVLGLDSTVGVTVADMIHHTKAVKRGAPNTFIVTDMPFMSYHLSKEDTLKNAAAI VQESGADALKLEGGEGVFESIRALTLGGIPVVSHLGLTPQSVGVLGGYKVQGKDEQSA KKLIEDSIKCEEAGAMMLVLECVPAELTAKIAETLSIPVIGIGAGVKADGQVLVYHDI IGHGVERTPKFVKQYTRIDETIETAISGYVQDVRHRAFPEQKHSFQMNQTVLDGLYGG K*" /label="panB CDS" gene complement(2023252..2024085) /gene="panB" /locus_tag="BSU_22430" /old_locus_tag="BSU22430" /label="panB gene" S_feature complement(2024086..2024293) /Source="Nicolas_S_feature" /locus_tag="new_2354673_2354880_c" /HighExp="LBGstat, dia15, Diami, H2O2, MG 15, Heat, Oxctl, MG 25, MG 10, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S852" promotor_-10 complement(2024288..2024307) /Source="Nicolas_upshift_promotors" /id="U1761" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=2662 /SigmaFactorBS="ctgccgatatcgaattgggctaatgTGTTGgtacaagcccgt tgatTTTGGTATACTTCCATTGGGcagtatcgcctgcgaactgcacctattattaaaa t" /listShort="S852, panB, panC, panD, S851, dinG, S850, S848, ypmA, ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2024293) /Source="Nicolas_upshifts" /id="U1761" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=2662 /SigmaFactorBS="ctgccgatatcgaattgggctaatgTGTTGgtacaagcccgt tgatTTTGGTATACTTCCATTGGGcagtatcgcctgcgaactgcacctattattaaaa t" /listShort="S852, panB, panC, panD, S851, dinG, S850, S848, ypmA, ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2024324..2024328) /Source="Nicolas_upshift_promotors" /id="U1761" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=2662 /SigmaFactorBS="ctgccgatatcgaattgggctaatgTGTTGgtacaagcccgt tgatTTTGGTATACTTCCATTGGGcagtatcgcctgcgaactgcacctattattaaaa t" /listShort="S852, panB, panC, panD, S851, dinG, S850, S848, ypmA, ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2024331..2025308) /gene="birA" /locus_tag="BSU_22440" /old_locus_tag="BSU22440" /EC_number="6.3.4.15" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12368242, 15459338, 28466579" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12368242, 15459338, 28466579; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="biotin acetyl-CoA-carboxylase ligase and biotin regulon repressor (BirA-biotinoyl-5'-AMP)" /protein_id="NP_390125.1" /db_xref="EnsemblGenomes-Gn:BSU22440" /db_xref="EnsemblGenomes-Tr:CAB14160" /db_xref="GOA:P0CI75" /db_xref="InterPro:IPR003142" /db_xref="InterPro:IPR004143" /db_xref="InterPro:IPR004408" /db_xref="InterPro:IPR004409" /db_xref="InterPro:IPR008988" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR030855" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11206" /db_xref="UniProtKB/Swiss-Prot:P0CI75" /translation="MRSTLRKDLIELFSQAGNEFISGQKISDALGCSRTAVWKHIEEL RKEGYEVEAVRRKGYRLIKKPGKLSESEIRFGLKTEVMGQHLIYHDVLSSTQKTAHEL ANNNAPEGTLVVADKQTAGRGRMSRVWHSQEGNGVWMSLILRPDIPLQKTPQLTLLAA VAVVQGIEEAAGIQTDIKWPNDILINGKKTVGILTEMQAEEDRVRSVIIGIGINVNQQ PNDFPDELKDIATSLSQAAGEKIDRAGVIQHILLCFEKRYRDYMTHGFTPIKLLWESY ALGIGTNMRARTLNGTFYGKALGIDDEGVLLLETNEGIKKIYSADIELG*" /label="birA CDS" gene complement(2024331..2025308) /gene="birA" /locus_tag="BSU_22440" /old_locus_tag="BSU22440" /label="birA gene" CDS complement(2025293..2026486) /gene="cca" /locus_tag="BSU_22450" /old_locus_tag="BSU22450" /EC_number="2.7.7.72" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9829937, 16109934, 20360175, 22940585" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9829937, 16109934, 20360175, 22940585; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA nucleotidyltransferase" /protein_id="NP_390126.1" /db_xref="EnsemblGenomes-Gn:BSU22450" /db_xref="EnsemblGenomes-Tr:CAB14161" /db_xref="GOA:P42977" /db_xref="InterPro:IPR002646" /db_xref="InterPro:IPR023068" /db_xref="InterPro:IPR032810" /db_xref="InterPro:IPR032828" /db_xref="SubtiList:BG11208" /db_xref="UniProtKB/Swiss-Prot:P42977" /translation="MEKVFIKALPVLRILIEAGHQAYFVGGAVRDSYMKRTIGDVDIA TDAAPDQVERLFQRTVDVGKEHGTIIVLWEDETYEVTTFRTESDYVDFRRPSEVQFIS SLEEDLKRRDLTINAMAMTADGKVLDYFGGKKDIDQKVIRTVGKPEDRFQEDALRMLR AVRFMSQLGFTLSPETEEAIAKEKSLLSHVSVERKTIEFEKLLQGRASRQALQTLIQT RLYEELPGFYHKRENLISTSEFPFFSLTSREELWAALLINLGIVLKDAPLFLKAWKLP GKVIKEAIHIADTFGQSLDAMTMYRAGKKALLSAAKISQLRQNEKLDEKKLKDIQYAY QNLPIKSLKDLDITGKDLLALRNRPAGKWVSEELQWIEQAVVTGKLSNQKKHIEEWLK TCGQH*" /label="cca CDS" gene complement(2025293..2026486) /gene="cca" /locus_tag="BSU_22450" /old_locus_tag="BSU22450" /label="cca gene" CDS complement(2026491..2027624) /gene="bshA" /locus_tag="BSU_22460" /old_locus_tag="BSU22460" /EC_number="2.4.1.-" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16751541, 20308541, 22569254, 27454321, 28301954" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16751541, 20308541, 22569254, 27454321, 28301954; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetyl-alpha-D-glucosaminyl L-malate synthase;malate glycosyltransferase for bacillithiol synthesis" /protein_id="NP_390127.1" /db_xref="EnsemblGenomes-Gn:BSU22460" /db_xref="EnsemblGenomes-Tr:CAB14162" /db_xref="GOA:P42982" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR023881" /db_xref="InterPro:IPR028098" /db_xref="PDB:5D00" /db_xref="PDB:5D01" /db_xref="SubtiList:BG11213" /db_xref="UniProtKB/Swiss-Prot:P42982" /translation="MRKLKIGITCYPSVGGSGIIATELGKQLAEKGHEIHFITSSIPF RLNTYHPNIHFHEVEVNQYAVFKYPPYDLTLASKIAEVAERENLDIIHAHYALPHAVC AYLAKQMLKRNIGIVTTLHGTDITVLGYDPSLKDLIRFAIESSDRVTAVSSALAAETY DLIKPEKKIETIYNFIDERVYLKKNTAAIKEKHGILPDEKVVIHVSNFRKVKRVQDVI RVFRNIAGKTKAKLLLVGDGPEKSTACELIRKYGLEDQVLMLGNQDRVEDLYSISDLK LLLSEKESFGLVLLEAMACGVPCIGTNIGGIPEVIKNNVSGFLVDVGDVTAATARAMS ILEDEQLSNRFTKAAIEMLENEFSSKKIVSQYEQIYADLAEPE*" /label="bshA CDS" gene complement(2026491..2027624) /gene="bshA" /locus_tag="BSU_22460" /old_locus_tag="BSU22460" /label="bshA gene" CDS complement(2027621..2028331) /gene="bshBA" /locus_tag="BSU_22470" /old_locus_tag="BSU22470" /EC_number="3.5.1.-" /function="4.10: Glutathione and analogs" /experiment="publication(s) with functional evidences, PMID:11004195, 20308541, 23894131, 28117687" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11004195, 20308541, 23894131, 28117687; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetyl-alpha-D-glucosaminyl L-malate deacetylase 1; malate N-acetylglucosamine N-acetyl hydrolase" /protein_id="NP_390128.2" /db_xref="EnsemblGenomes-Gn:BSU22470" /db_xref="EnsemblGenomes-Tr:CAB14163" /db_xref="GOA:P42981" /db_xref="InterPro:IPR003737" /db_xref="InterPro:IPR023842" /db_xref="InterPro:IPR024078" /db_xref="SubtiList:BG11212" /db_xref="UniProtKB/Swiss-Prot:P42981" /translation="MYNADVLAFGAHSDDVEIGMGGTIAKFVKQEKKVMICDLTEAEL SSNGTVSLRKEEAAEAARILGADKRIQLTLPDRGLIMSDQAIRSIVTVIRICRPKAVF MPYKKDRHPDHGNAAALVEEAIFSAGIHKYKDEKSLPAHKVSKVYYYMINGFHQPDFV IDISDTIEAKKQSLNAYKSQFIPSKDSVSTPLTNGYIEIVEAREKLYGKEAGVEYAEG FFSKRMLMLDHDVLGGEQ*" /label="bshBA CDS" gene complement(2027621..2028331) /gene="bshBA" /locus_tag="BSU_22470" /old_locus_tag="BSU22470" /label="bshBA gene" CDS complement(2028324..2028737) /gene="mgsA" /locus_tag="BSU_22480" /old_locus_tag="BSU22480" /EC_number="4.2.3.3" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9489667, 10368300, 10715115, 11423008, 15489434, 21992469, 23894131, 28807600" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9489667, 10368300, 10715115, 11423008, 15489434, 21992469, 23894131, 28807600; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylglyoxal synthase" /protein_id="NP_390129.1" /db_xref="EnsemblGenomes-Gn:BSU22480" /db_xref="EnsemblGenomes-Tr:CAB14164" /db_xref="GOA:P42980" /db_xref="InterPro:IPR004363" /db_xref="InterPro:IPR011607" /db_xref="InterPro:IPR018148" /db_xref="InterPro:IPR036914" /db_xref="SubtiList:BG11211" /db_xref="UniProtKB/Swiss-Prot:P42980" /translation="MKIALIAHDKKKQDMVQFTTAYRDILKNHDLYATGTTGLKIHEA TGLQIERFQSGPLGGDQQIGALIAANALDLVIFLRDPLTAQPHEPDVSALIRLCDVYS IPLATNMGTAEILVRTLDEGVFEFRDLLRGEEPNV*" /label="mgsA CDS" gene complement(2028324..2028737) /gene="mgsA" /locus_tag="BSU_22480" /old_locus_tag="BSU22480" /label="mgsA gene" CDS complement(2028753..2029556) /gene="dapB" /locus_tag="BSU_22490" /old_locus_tag="BSU22490" /EC_number="1.17.1.8" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 6422596, 9398235, 12682299, 20503968; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="(4S)-4-hydroxy-2,3,4, 5-tetrahydro-(2S)-dipicolinic acid (HTPA) dehydratase reductase" /protein_id="NP_390130.1" /db_xref="EnsemblGenomes-Gn:BSU22490" /db_xref="EnsemblGenomes-Tr:CAB14165" /db_xref="GOA:P42976" /db_xref="InterPro:IPR000846" /db_xref="InterPro:IPR022663" /db_xref="InterPro:IPR022664" /db_xref="InterPro:IPR023940" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11207" /db_xref="UniProtKB/Swiss-Prot:P42976" /translation="MSNETIKLVIAGPRGRMGQEAVKLAERTPHFDLVGAIDHTYDQQ KLSDVMPVESDAFIYTDIHACFTETQPDVLIDLTTPEIGKVHTKIALEHGVRPVVGTT GFSEADLKELTSLTEEKGIGAIIAPNFALGAILMMKFSKMAANYFEDVEIIELHHDQK LDAPSGTALKTAEMISEVRKEKQQGHPDEKEILPGARGAEQNGIRLHSVRLPGLIAHQ EVMFGMDGQTLQIRHDSYNRASFMSGVKLSVEQVMKIDQLVYGLENIID*" /label="dapB CDS" gene complement(2028753..2029556) /gene="dapB" /locus_tag="BSU_22490" /old_locus_tag="BSU22490" /label="dapB gene" CDS complement(2029568..2029903) /gene="ypjD" /locus_tag="BSU_22500" /old_locus_tag="BSU22500" /function="16.3: Control" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 16390452, 20529853, 20944217, 21733847, 24339782, 26920050, 28117687; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oxidized nucleotide pyrophosphohydrolase" /protein_id="NP_390131.1" /db_xref="EnsemblGenomes-Gn:BSU22500" /db_xref="EnsemblGenomes-Tr:CAB14166" /db_xref="InterPro:IPR004518" /db_xref="InterPro:IPR012359" /db_xref="PDB:2GTA" /db_xref="SubtiList:BG11210" /db_xref="UniProtKB/Swiss-Prot:P42979" /translation="MSDKTMKDIQAEVDRYIGQFKEGYFSPLAMMARLTEELGELARE VNHRYGEKPKKATEDDKSMEEEIGDVLFVLVCLANSLDISLEEAHDRVMHKFNTRDKD RWTRKEEGK*" /label="ypjD CDS" gene complement(2029568..2029903) /gene="ypjD" /locus_tag="BSU_22500" /old_locus_tag="BSU22500" /label="ypjD gene" promotor_-10 complement(2029923..2029942) /Source="Nicolas_upshift_promotors" /id="U1762" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.632367632367632" /psig=1 /xcortree=2567 /SigmaFactorBS="atgaaaaagaaaacagcaaacgtgcttaaaCATTTGTCaaac gtatctgaaTTAGCTAACATGTAAGAGGAtgataggaggtttcgttcagtgagtgata a" /listShort="ypjD, dapB, mgsA, ypjG, ypjH, cca, birA, S852, panB, panC, panD, S851, dinG, S850, S848, ypmA, ypmB, aspB" /listLong="S847, asnS, S846, dnaD, nth, ypoC" /label="promotor_-10" upshifts complement(2029933) /Source="Nicolas_upshifts" /id="U1762" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.632367632367632" /psig=1 /xcortree=2567 /SigmaFactorBS="atgaaaaagaaaacagcaaacgtgcttaaaCATTTGTCaaac gtatctgaaTTAGCTAACATGTAAGAGGAtgataggaggtttcgttcagtgagtgata a" /listShort="ypjD, dapB, mgsA, ypjG, ypjH, cca, birA, S852, panB, panC, panD, S851, dinG, S850, S848, ypmA, ypmB, aspB" /listLong="S847, asnS, S846, dnaD, nth, ypoC" /label="upshifts" promotor_-35 complement(2029956..2029963) /Source="Nicolas_upshift_promotors" /id="U1762" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.632367632367632" /psig=1 /xcortree=2567 /SigmaFactorBS="atgaaaaagaaaacagcaaacgtgcttaaaCATTTGTCaaac gtatctgaaTTAGCTAACATGTAAGAGGAtgataggaggtttcgttcagtgagtgata a" /listShort="ypjD, dapB, mgsA, ypjG, ypjH, cca, birA, S852, panB, panC, panD, S851, dinG, S850, S848, ypmA, ypmB, aspB" /listLong="S847, asnS, S846, dnaD, nth, ypoC" /label="promotor_-35" promotor_-35 2029972..2029979 /Source="Nicolas_upshift_promotors" /id="U1763" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=2405 /SigmaFactorBS="ctaattcagatacgtttgacaaatgtttaagcaCGTTTGCTg ttttctttttcaTCCACTATAATATAAACGCTatctaatggaaggaaaaggggttttg t" /listShort="ypjC" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(2029988..2030007) /Source="Nicolas_upshift_promotors" /id="U1764" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.415584415584416" /psig="0.995004995004995" /xcortree=2307 /SigmaFactorBS="tttttaatctaatttctccaagcatcacacaaaacccctttt ccttccattagatagcgtTTATATTATAGTGGATGAAAaagaaaacagcaaacgtgct t" /listShort="ypjD, dapB, mgsA, ypjG, ypjH, cca, birA, S852, panB, panC, panD, S851, dinG, S850, S848, ypmA" /listLong="ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 2029993..2030012 /Source="Nicolas_upshift_promotors" /id="U1763" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=2405 /SigmaFactorBS="ctaattcagatacgtttgacaaatgtttaagcaCGTTTGCTg ttttctttttcaTCCACTATAATATAAACGCTatctaatggaaggaaaaggggttttg t" /listShort="ypjC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2029999 /Source="Nicolas_upshifts" /id="U1763" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=2405 /SigmaFactorBS="ctaattcagatacgtttgacaaatgtttaagcaCGTTTGCTg ttttctttttcaTCCACTATAATATAAACGCTatctaatggaaggaaaaggggttttg t" /listShort="ypjC" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2030007) /Source="Nicolas_upshifts" /id="U1764" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.415584415584416" /psig="0.995004995004995" /xcortree=2307 /SigmaFactorBS="tttttaatctaatttctccaagcatcacacaaaacccctttt ccttccattagatagcgtTTATATTATAGTGGATGAAAaagaaaacagcaaacgtgct t" /listShort="ypjD, dapB, mgsA, ypjG, ypjH, cca, birA, S852, panB, panC, panD, S851, dinG, S850, S848, ypmA" /listLong="ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /label="upshifts" CDS 2030043..2030915 /gene="ypjC" /locus_tag="BSU_22510" /old_locus_tag="BSU22510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390132.2" /db_xref="EnsemblGenomes-Gn:BSU22510" /db_xref="EnsemblGenomes-Tr:CAB14167" /db_xref="GOA:P42978" /db_xref="InterPro:IPR003740" /db_xref="InterPro:IPR019264" /db_xref="SubtiList:BG11209" /db_xref="UniProtKB/Swiss-Prot:P42978" /translation="MLGEIRLKNIFFILIGAAIFSFGLVHFNMQNNLAEGGFTGITLL LYALFHISPSISNLVLNIPIFFIGWRLLGRTMFVYTLVGTVALSLFLSIFQRYEIHMP LQHDLALAALFAGVFIGAGLGIIFKFGGTTGGVDIIARLVNKYFGIPMGRTMFAFDAC VIILSLLTYLSYKEAMYTLVAVFVAARLIDFIQEGGYAAKGATIISSKNDLIQKKILE EMERGVTILKGQGSYTKEDIDVLYCVVPKNELVMLKSVINSIDPHAFVAVSDVHDVLG EGFTLDENKNPLPR*" /label="ypjC CDS" gene 2030043..2030915 /gene="ypjC" /locus_tag="BSU_22510" /old_locus_tag="BSU22510" /label="ypjC gene" CDS complement(2030957..2031751) /gene="ypjB" /locus_tag="BSU_22520" /old_locus_tag="BSU22520" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12662922" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12662922; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="sporulation septum-associated protein" /protein_id="NP_390133.1" /db_xref="EnsemblGenomes-Gn:BSU22520" /db_xref="EnsemblGenomes-Tr:CAB14168" /db_xref="GOA:P54393" /db_xref="InterPro:IPR014231" /db_xref="SubtiList:BG11500" /db_xref="UniProtKB/Swiss-Prot:P54393" /translation="MKRKLTICLLIALIFYNGNAKAAERGSLEELNDLSDTVFQMTRQ AKYEEALQVLEYFEKTLKSAEKKQQDPMLTGAQIRQITLGYNDMVRSLKQADTSDTQK LRAAAQFRMLMDAVDNRSDPLWGSLEKPIMEAFTELKRDVQKNGSTSFHEKWNEFISL YDLIYPSLTIDVSEDQLETVGKHIDVIEQEEFQQMTESTKLERLSLLQHDLKNVFDRV EEDDADPSLLWVIITTGSIIITALTYVGYRKYKAEKNKLKKRDYPK*" /label="ypjB CDS" gene complement(2030957..2031751) /gene="ypjB" /locus_tag="BSU_22520" /old_locus_tag="BSU22520" /label="ypjB gene" downshifts complement(2030982) /Source="Nicolas_upshifts" /id="D1176" /incds=0 /nref=4 /ntot=106 /MaxReadThrough="1.96946" /MaxDrop="3.51024" /score="34.9661402" /energy="-11.3" /TU="NA" /idTUdmin="U1765" /TUdmin=198 /isTUend="FALSE" /label="downshifts" S_feature complement(2031752..2031819) /Source="Nicolas_S_feature" /locus_tag="new_2362339_2362406_c" /HighExp="LBGstat, C30, S0, LoTm, G180, G135, G150, Oxctl, Paraq, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.866" /TUlongSig="SigH, SigA" /TUlongPSig="1, 0.999" /label="S853" CDS complement(2031820..2032377) /gene="ypjA" /locus_tag="BSU_22530" /old_locus_tag="BSU22530" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406; Product type m:membrane component" /codon_start=1 /transl_table=11 /product="conserved integral inner membrane protein of unknown function" /protein_id="NP_390134.1" /db_xref="EnsemblGenomes-Gn:BSU22530" /db_xref="EnsemblGenomes-Tr:CAB14169" /db_xref="GOA:P54392" /db_xref="InterPro:IPR009845" /db_xref="SubtiList:BG11499" /db_xref="UniProtKB/Swiss-Prot:P54392" /translation="MLILVLAINFLGTVYGYYWYLPQLLETPARFLIFVPDSPTATFF FLFVLLAFLMKRNAPLLEALALVTLVKYGLWAVAMNFLVLAVTGDLPWEGYMLIASHF AMAVQGVLYSPYFRFSFWHLAIAAVWTLHNDVIDYLFDMMPQYSMLSDYMTEIGYGTF WLSIFSIALAYFLVVSKKQTKLELM*" /label="ypjA CDS" gene complement(2031820..2032377) /gene="ypjA" /locus_tag="BSU_22530" /old_locus_tag="BSU22530" /label="ypjA gene" S_feature complement(2032378..2032457) /Source="Nicolas_S_feature" /locus_tag="new_2362965_2363044_c" /HighExp="C30, UNK1, G135, BMM, G150, G180, Oxctl, LoTm, Paraq, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.866" /TUlongSig="SigH, SigA" /TUlongPSig="1, 0.999" /label="S854" downshifts complement(2032502) /Source="Nicolas_upshifts" /id="D1177" /incds=0 /nref=131 /ntot=215 /MaxReadThrough="3.97061" /MaxDrop="6.41485" /score="13.3880841" /energy="-8" /TU="U1765" /idTUdmin="U1767" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(2032524..2033291) /gene="qcrC" /locus_tag="BSU_22540" /old_locus_tag="BSU22540" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7592464, 8647852, 12446663, 12615356, 19114526; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="menaquinol:cytochrome c oxidoreductase (cytochrome cc subunit)" /protein_id="NP_390135.1" /db_xref="EnsemblGenomes-Gn:BSU22540" /db_xref="EnsemblGenomes-Tr:CAB14170" /db_xref="GOA:P46913" /db_xref="InterPro:IPR005798" /db_xref="InterPro:IPR009056" /db_xref="InterPro:IPR012049" /db_xref="InterPro:IPR027387" /db_xref="InterPro:IPR036150" /db_xref="InterPro:IPR036909" /db_xref="SubtiList:BG11327" /db_xref="UniProtKB/Swiss-Prot:P46913" /translation="MHRGKGMKFVGDSRIPAEKKPNIPKDYSEYPGKTEAFWPNFLLK EWMVGAVFLIGFLVLTIVHQPPLERMADPTDTGYIPLPDWYFLFLYQLLKYEYAAGSF TVVGAMIMPGLAFGALLLAPFLDRGTERRPWKRPVAVGMMLLAISAAVFLTWQSVATH DWAKAEEQGKITKEADIDTNAEGYKVFKEQGCISCHGDNLQGGAAGPSLVDSGLKPDE IKKIAVEGKGKMPAGVFKGNDKQLEELAKFISETTAK*" /label="qcrC CDS" gene complement(2032524..2033291) /gene="qcrC" /locus_tag="BSU_22540" /old_locus_tag="BSU22540" /label="qcrC gene" CDS complement(2033326..2034000) /gene="qcrB" /locus_tag="BSU_22550" /old_locus_tag="BSU22550" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7592464, 8647852, 12446663, 12615356, 15849754, 16850406; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="menaquinol:cytochrome c oxidoreductase (cytochrome b subunit)" /protein_id="NP_390136.1" /db_xref="EnsemblGenomes-Gn:BSU22550" /db_xref="EnsemblGenomes-Tr:CAB14171" /db_xref="GOA:P46912" /db_xref="InterPro:IPR005797" /db_xref="InterPro:IPR016174" /db_xref="InterPro:IPR023530" /db_xref="InterPro:IPR027387" /db_xref="SubtiList:BG11326" /db_xref="UniProtKB/Swiss-Prot:P46912" /translation="MLNKIYDWVDERLDITPMWRDIADHEVPEHVNPAHHFSAFVYCF GGLTFFVTVIQVLSGMFLTMYYVPDIKNAWESVYYLQNEVAFGQIVRGMHHWGASLVI VMMFLHTLRVFFQGAYKKPRELNWIVGVLIFFVMLGLGFTGYLLPWDMKALFATKVGL QIAEATPLIGTQVKTLLAGHPDIVGAQTLTRFFAIHVFFLPAALFGLMAAHFIMIRKQ GISGPL*" /label="qcrB CDS" gene complement(2033326..2034000) /gene="qcrB" /locus_tag="BSU_22550" /old_locus_tag="BSU22550" /label="qcrB gene" CDS complement(2034002..2034505) /gene="qcrA" /locus_tag="BSU_22560" /old_locus_tag="BSU22560" /EC_number="1.10.2.-" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7592464, 8647852, 12446663, 12615356, 24652282, 27503613; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="menaquinol:cytochrome c oxidoreductase (iron-sulfur subunit)" /protein_id="NP_390137.1" /db_xref="EnsemblGenomes-Gn:BSU22560" /db_xref="EnsemblGenomes-Tr:CAB14172" /db_xref="GOA:P46911" /db_xref="InterPro:IPR006311" /db_xref="InterPro:IPR014349" /db_xref="InterPro:IPR014909" /db_xref="InterPro:IPR017941" /db_xref="InterPro:IPR036922" /db_xref="SubtiList:BG11325" /db_xref="UniProtKB/Swiss-Prot:P46911" /translation="MGGKHDISRRQFLNYTLTGVGGFMAASMLMPMVRFALDPVLKST GKQDMVQVVSVDELTKEPQRFDFKINQVDAWYESEESRSAWVFKNGDEIVALSPICKH LGCTVNWNSDPKNPNKFFCPCHYGLYEKDGTNVPGTPPLAPLDHYEQEVKDGFLYLGK AKPKGEG*" /label="qcrA CDS" gene complement(2034002..2034505) /gene="qcrA" /locus_tag="BSU_22560" /old_locus_tag="BSU22560" /label="qcrA gene" downshifts 2034514 /Source="Nicolas_upshifts" /id="D1178" /incds=0 /nref=1 /ntot=80 /MaxReadThrough="1.24169" /MaxDrop="3.42621" /score="0.352684802" /energy="-11.5" /TU="NA" /idTUdmin="U1763" /TUdmin=3608 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2034569..2034588) /Source="Nicolas_upshift_promotors" /id="U1765" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.595404595404595" /psig="0.866133866133866" /xcortree=512 /SigmaFactorBS="ataaacaatattttggctaTATTGACCttgctgagagattcA TATATTATGAGGGTGTCTAgagttattgcaatattttctattttagtcagtttgcagg g" /listShort="qcrA, qcrB, qcrC, S854, ypjA, S853, ypjB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2034569) /Source="Nicolas_upshifts" /id="U1765" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.595404595404595" /psig="0.866133866133866" /xcortree=512 /SigmaFactorBS="ataaacaatattttggctaTATTGACCttgctgagagattcA TATATTATGAGGGTGTCTAgagttattgcaatattttctattttagtcagtttgcagg g" /listShort="qcrA, qcrB, qcrC, S854, ypjA, S853, ypjB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2034603..2034610) /Source="Nicolas_upshift_promotors" /id="U1765" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.595404595404595" /psig="0.866133866133866" /xcortree=512 /SigmaFactorBS="ataaacaatattttggctaTATTGACCttgctgagagattcA TATATTATGAGGGTGTCTAgagttattgcaatattttctattttagtcagtttgcagg g" /listShort="qcrA, qcrB, qcrC, S854, ypjA, S853, ypjB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2034648..2035094) /gene="ypiF" /locus_tag="BSU_22570" /old_locus_tag="BSU22570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15743949" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390138.1" /db_xref="EnsemblGenomes-Gn:BSU22570" /db_xref="EnsemblGenomes-Tr:CAB14173" /db_xref="InterPro:IPR019615" /db_xref="SubtiList:BG11498" /db_xref="UniProtKB/Swiss-Prot:P54391" /translation="MRWRITDAKDYLQAKDYIDTAVIPLINIRVNNHFKMAAEKGEFT QLLSEELERQLKGRVYLLPPYTYVDRNEITVQGLKDLREELITEFPHVVLLTSDESWR AEDALGKMIVTSSVPLEHLNDSLKRKILDERTAEILNVLLQLWSTL*" /label="ypiF CDS" gene complement(2034648..2035094) /gene="ypiF" /locus_tag="BSU_22570" /old_locus_tag="BSU22570" /label="ypiF gene" downshifts 2035097 /Source="Nicolas_upshifts" /id="D1179" /incds=0 /nref=2 /ntot=54 /MaxReadThrough="0.94679" /MaxDrop="2.794" /score="0.352684802" /energy="-11.5" /TU="NA" /idTUdmin="U1763" /TUdmin=4191 /isTUend="FALSE" /label="downshifts" CDS complement(2035149..2035688) /gene="ypiB" /locus_tag="BSU_22580" /old_locus_tag="BSU22580" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16847875" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390139.1" /db_xref="EnsemblGenomes-Gn:BSU22580" /db_xref="EnsemblGenomes-Tr:CAB14174" /db_xref="InterPro:IPR011188" /db_xref="InterPro:IPR014957" /db_xref="InterPro:IPR014963" /db_xref="SubtiList:BG11497" /db_xref="UniProtKB/Swiss-Prot:P54390" /translation="MQTPVSVNEKKDFIRWFLNHYQLKRRECVWILNYLMSHDSLMEK VHFVEQAEFCPRGIIMSTHCVEEVPFRFYKENVMTTDAEKSFHDIRLNKQQDLFIQLN FRSAYSSPEYAAVLESNPHIPKNLFENKKDQGLAEQILEHAISTFQREKLLKDIDDAL DRHDKEAFEQLSRQLNQLT*" /label="ypiB CDS" gene complement(2035149..2035688) /gene="ypiB" /locus_tag="BSU_22580" /old_locus_tag="BSU22580" /label="ypiB gene" downshifts complement(2035162) /Source="Nicolas_upshifts" /id="D1180" /incds=0 /nref=84 /ntot=250 /MaxReadThrough="5.68366" /MaxDrop="5.48142" /score="16.8021869" /energy="-11.2" /TU="U1766,U1767" /idTUdmin="U1768" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2035721..2035739) /Source="Nicolas_upshift_promotors" /id="U1766" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=519 /SigmaFactorBS="attttgcgaatcgaggatgaattttctagataaGCAGGAATA ttaaccattcaTGTGGAACATATAAGTATAtagattatacgaacgatagaggagggaa t" /listShort="ypiB, ypiF, qcrA, qcrB" /listLong="qcrC, S854, ypjA, S853, ypjB" /label="promotor_-10" upshifts complement(2035732) /Source="Nicolas_upshifts" /id="U1766" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=519 /SigmaFactorBS="attttgcgaatcgaggatgaattttctagataaGCAGGAATA ttaaccattcaTGTGGAACATATAAGTATAtagattatacgaacgatagaggagggaa t" /listShort="ypiB, ypiF, qcrA, qcrB" /listLong="qcrC, S854, ypjA, S853, ypjB" /label="upshifts" promotor_-35 complement(2035751..2035759) /Source="Nicolas_upshift_promotors" /id="U1766" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=519 /SigmaFactorBS="attttgcgaatcgaggatgaattttctagataaGCAGGAATA ttaaccattcaTGTGGAACATATAAGTATAtagattatacgaacgatagaggagggaa t" /listShort="ypiB, ypiF, qcrA, qcrB" /listLong="qcrC, S854, ypjA, S853, ypjB" /label="promotor_-35" CDS complement(2035760..2037031) /gene="ypiA" /locus_tag="BSU_22590" /old_locus_tag="BSU22590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390140.1" /db_xref="EnsemblGenomes-Gn:BSU22590" /db_xref="EnsemblGenomes-Tr:CAB14175" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="SubtiList:BG11496" /db_xref="UniProtKB/Swiss-Prot:P54389" /translation="MNTLIQEAIKLVEAGETEKGLNTLSKAEKQLHDEDKAIAAQLYY EWGDVEKAISLISDLHDLYPNETELTNFYAELLIDIDEEEKALAVLETIPETDPSYPE SLLLMADLYQMQGLFEVSEQKLFQAKSILDNEPVIDFALGELYFAQGAYAKAVQYFKT TAEEQSEIGGVNVHQRLAESLSASGEFEDAIPWYEKAVDENPDPNTIFGYGFTALQAG LVKTAIKQLSDLKELDPSYTSLYMPLSKSYEAEGMYEEALKTAKEGIRYDEYNKELFL YAAKMALKIGKSEEGKKLLQEALALDPGFVEALHTLLAVYHKEEDYDQIIDLIQEVRS YGEEDPKYNWYLASAYTELEQYEEAKQSFEAAYLHYREDRDFLYEYASFLLEEGLQKE ALPLLKKVLEMDGANEELEETILRIEDEFSR*" /label="ypiA CDS" gene complement(2035760..2037031) /gene="ypiA" /locus_tag="BSU_22590" /old_locus_tag="BSU22590" /label="ypiA gene" S_feature complement(2037032..2037099) /Source="Nicolas_S_feature" /locus_tag="new_2367619_2367686_c" /HighExp="dia15, Diami, dia5, Etha, H2O2, T1.30H, LPhT, T0.30H, T3.0H, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigEF, SigA" /TUshortPSig="0.999, 0.999, 0.999, 1" /TUlongSig="Sig-, Sig-, SigA, SigA, SigA, SigA, SigA, SigA" /TUlongPSig="0.042, 0.047, 0.994, 0.999, 1, 0.999, 1, 0.998" /label="S855" promotor_-10 complement(2037096..2037115) /Source="Nicolas_upshift_promotors" /id="U1767" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.977022977022977" /psig="0.999000999001" /xcortree=2047 /SigmaFactorBS="ttcccttccgtacagaagcatctTATTTGCCgggggcattcg tcTGAATTATGATAAGATTAACccgaacaaataaagctttttttgtatggttgatgtt g" /listShort="S855, ypiA, ypiB, ypiF, qcrA, qcrB, qcrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2037099) /Source="Nicolas_upshifts" /id="U1767" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.977022977022977" /psig="0.999000999001" /xcortree=2047 /SigmaFactorBS="ttcccttccgtacagaagcatctTATTTGCCgggggcattcg tcTGAATTATGATAAGATTAACccgaacaaataaagctttttttgtatggttgatgtt g" /listShort="S855, ypiA, ypiB, ypiF, qcrA, qcrB, qcrC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2037129..2037136) /Source="Nicolas_upshift_promotors" /id="U1767" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.977022977022977" /psig="0.999000999001" /xcortree=2047 /SigmaFactorBS="ttcccttccgtacagaagcatctTATTTGCCgggggcattcg tcTGAATTATGATAAGATTAACccgaacaaataaagctttttttgtatggttgatgtt g" /listShort="S855, ypiA, ypiB, ypiF, qcrA, qcrB, qcrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2037166..2037185) /Source="Nicolas_upshift_promotors" /id="U1768" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.788211788211788" /psig="0.999000999001" /xcortree=569 /SigmaFactorBS="ctgtacagagggcgatcttccttttttcaTTTTCTATctcaa gatctTTTGGTAAACTAATAAGACTcaataattcccttccgtacagaagcatcttatt t" /listShort="S855, ypiA, ypiB" /listLong="ypiF, qcrA, qcrB, qcrC, S854, ypjA, S853, ypjB" /label="promotor_-10" upshifts complement(2037172) /Source="Nicolas_upshifts" /id="U1768" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.788211788211788" /psig="0.999000999001" /xcortree=569 /SigmaFactorBS="ctgtacagagggcgatcttccttttttcaTTTTCTATctcaa gatctTTTGGTAAACTAATAAGACTcaataattcccttccgtacagaagcatcttatt t" /listShort="S855, ypiA, ypiB" /listLong="ypiF, qcrA, qcrB, qcrC, S854, ypjA, S853, ypjB" /label="upshifts" S_feature complement(2037174..2037318) /Source="Nicolas_S_feature" /locus_tag="new_2367761_2367905_c" /HighExp="S3, LoTm, M9-stat, S4, Etha, S5, T5.0H, BT, B36, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA, Sig-, SigA" /TUshortPSig="0.999, 1, 0.047, 0.994" /TUlongSig="Sig-, SigA, SigA, SigA, SigA, SigA" /TUlongPSig="0.042, 0.999, 1, 0.999, 1, 0.998" /label="S856" promotor_-35 complement(2037196..2037203) /Source="Nicolas_upshift_promotors" /id="U1768" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.788211788211788" /psig="0.999000999001" /xcortree=569 /SigmaFactorBS="ctgtacagagggcgatcttccttttttcaTTTTCTATctcaa gatctTTTGGTAAACTAATAAGACTcaataattcccttccgtacagaagcatcttatt t" /listShort="S855, ypiA, ypiB" /listLong="ypiF, qcrA, qcrB, qcrC, S854, ypjA, S853, ypjB" /label="promotor_-35" promotor_-10 complement(2037300..2037318) /Source="Nicolas_upshift_promotors" /id="U1769" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=983 /SigmaFactorBS="aaaaaatcctgaagttttacttcaggattttttatgcagATC ATAattcgaggcgaaaaaACATAGCTTGTCTTATAGAacggatagaaaaacgaaaagg g" /listShort="S856, S855, ypiA" /listLong="ypiB, ypiF, qcrA, qcrB, qcrC" /label="promotor_-10" upshifts complement(2037318) /Source="Nicolas_upshifts" /id="U1769" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=983 /SigmaFactorBS="aaaaaatcctgaagttttacttcaggattttttatgcagATC ATAattcgaggcgaaaaaACATAGCTTGTCTTATAGAacggatagaaaaacgaaaagg g" /listShort="S856, S855, ypiA" /listLong="ypiB, ypiF, qcrA, qcrB, qcrC" /label="upshifts" promotor_-35 complement(2037334..2037339) /Source="Nicolas_upshift_promotors" /id="U1769" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=983 /SigmaFactorBS="aaaaaatcctgaagttttacttcaggattttttatgcagATC ATAattcgaggcgaaaaaACATAGCTTGTCTTATAGAacggatagaaaaacgaaaagg g" /listShort="S856, S855, ypiA" /listLong="ypiB, ypiF, qcrA, qcrB, qcrC" /label="promotor_-35" CDS complement(2037367..2038653) /gene="aroA" /locus_tag="BSU_22600" /old_locus_tag="BSU22600" /EC_number="2.5.1.19" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 3106153, 22938038, 24628944; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvoylshikimate-3-phosphate synthase)" /protein_id="NP_390141.1" /db_xref="EnsemblGenomes-Gn:BSU22600" /db_xref="EnsemblGenomes-Tr:CAB14176" /db_xref="GOA:P20691" /db_xref="InterPro:IPR001986" /db_xref="InterPro:IPR006264" /db_xref="InterPro:IPR013792" /db_xref="InterPro:IPR023193" /db_xref="InterPro:IPR036968" /db_xref="SubtiList:BG10294" /db_xref="UniProtKB/Swiss-Prot:P20691" /translation="MKRDKVQTLHGEIHIPGDKSISHRSVMFGALAAGTTTVKNFLPG ADCLSTIDCFRKMGVHIEQSSSDVVIHGKGIDALKEPESLLDVGNSGTTIRLMLGILA GRPFYSAVAGDESIAKRPMKRVTEPLKKMGAKIDGRAGGEFTPLSVSGASLKGIDYVS PVASAQIKSAVLLAGLQAEGTTTVTEPHKSRDHTERMLSAFGVKLSEDQTSVSIAGGQ KLTAADIFVPGDISSAAFFLAAGAMVPNSRIVLKNVGLNPTRTGIIDVLQNMGAKLEI KPSADSGAEPYGDLIIETSSLKAVEIGGDIIPRLIDEIPIIALLATQAEGTTVIKDAA ELKVKETNRIDTVVSELRKLGAEIEPTADGMKVYGKQTLKGGAAVSSHGDHRIGMMLG IASCITEEPIEIEHTDAIHVSYPTFFEHLNKLSKKS*" /label="aroA CDS" gene complement(2037367..2038653) /gene="aroA" /locus_tag="BSU_22600" /old_locus_tag="BSU22600" /label="aroA gene" downshifts complement(2037390) /Source="Nicolas_upshifts" /id="D1181" /incds=0 /nref=68 /ntot=212 /MaxReadThrough="3.64462" /MaxDrop="4.25336" /score="16.8021869" /energy="-11.2" /TU="U1770,U1772,U1773" /idTUdmin="U1775" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" CDS complement(2038664..2039779) /gene="tyrA" /locus_tag="BSU_22610" /old_locus_tag="BSU22610" /EC_number="1.3.1.12" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3106153, 3121591" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3106153, 3121591; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="prephenate dehydrogenase" /protein_id="NP_390142.1" /db_xref="EnsemblGenomes-Gn:BSU22610" /db_xref="EnsemblGenomes-Tr:CAB14177" /db_xref="GOA:P20692" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR003099" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10293" /db_xref="UniProtKB/Swiss-Prot:P20692" /translation="MNQMKDTILLAGLGLIGGSIALAIKKNHPGKRIIGIDISDEQAV AALKLGVIDDRADSFISGVKEAATVIIATPVEQTLVMLEELAHSGIEHELLITDVGST KQKVVDYADQVLPSRYQFVGGHPMAGSHKSGVAAAKEFLFENAFYILTPGQKTDKQAV EQLKNLLKGTNAHFVEMSPEEHDGVTSVISHFPHIVAASLVHQTHHSENLYPLVKRFA AGGFRDITRIASSSPAMWRDILLHNKDKILDRFDEWIREIDKIRTYVEQEDAENLFRY FKTAKDYRDGLPLRQKGAIPAFYDLYVDVPDHPGVISEITAILAAERISITNIRIIET REDINGILRISFQSDDDRKRAEQCIEARAEYETFYAD*" /label="tyrA CDS" gene complement(2038664..2039779) /gene="tyrA" /locus_tag="BSU_22610" /old_locus_tag="BSU22610" /label="tyrA gene" CDS complement(2039828..2040910) /gene="hisC" /locus_tag="BSU_22620" /old_locus_tag="BSU22620" /EC_number="2.6.1.5" /EC_number="2.6.1.9" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:4431, 418816, 824269, 11518529, 15102328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4431, 418816, 824269, 11518529, 15102328; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="histidinol-phosphate aminotransferase; tyrosine/phenylalanine aminotransferase (promiscuous)" /protein_id="NP_390143.2" /db_xref="EnsemblGenomes-Gn:BSU22620" /db_xref="EnsemblGenomes-Tr:CAB14178" /db_xref="GOA:P17731" /db_xref="InterPro:IPR001917" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR005861" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG10292" /db_xref="UniProtKB/Swiss-Prot:P17731" /translation="MRIKEHLKQLKPYQPGKPIEAVKSEYGLDKVVKLASNENPYGCS EAAKEALHHEIQQLALYPDGYSAALRTRLSKHLNVSETSLIFGNGSDEIIQIICRAFL NDKTNTVTAAPTFPQYKHNAVIEGAEVREIALRPDGSHDLDAMLEAIDEQTQVVWICS PNNPTGTYTSEGELLAFLERVPSRVLVVLDEAYYEYVTAEDYPETVPLLSKYSNLMIL RTFSKAYGLAALRVGYGIADENLIRQIEPAREPFNTSRLGQAAAIAALDDQAFIASCV EQNNAGLQQYYDFAKTHGLKCYPSQTNFVLIDFKRPADELFQALLEKGYIVRSGNALG FPTSLRITIGTKEQNEEILAILAEIL*" /label="hisC CDS" gene complement(2039828..2040910) /gene="hisC" /locus_tag="BSU_22620" /old_locus_tag="BSU22620" /label="hisC gene" CDS complement(2040921..2041724) /gene="trpA" /locus_tag="BSU_22630" /old_locus_tag="BSU22630" /EC_number="4.2.1.20" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2422155, 9383185, 10714985, 12963367, 17114058, 17555270" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2422155, 9383185, 10714985, 12963367, 17114058, 17555270; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="tryptophan synthase (alpha subunit)" /protein_id="NP_390144.1" /db_xref="EnsemblGenomes-Gn:BSU22630" /db_xref="EnsemblGenomes-Tr:CAB14179" /db_xref="GOA:P07601" /db_xref="InterPro:IPR002028" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR018204" /db_xref="SubtiList:BG10291" /db_xref="UniProtKB/Swiss-Prot:P07601" /translation="MFKLDLQPSEKLFIPFITAGDPVPEVSIELAKSLQKAGATALEL GVAYSDPLADGPVIQRASKRALDQGMNIVKAIELGGEMKKNGVNIPIILFTYYNPVLQ LNKEYFFALLRENHIDGLLVPDLPLEESNSLQEECKSHEVTYISLVAPTSESRLKTII EQAEGFVYCVSSLGVTGVRNEFNSSVYPFIRTVKNLSTVPVAVGFGISNREQVIKMNE ISDGVVVGSALVRKIEELKDRLISAETRNQALQEFEDYAMAFSGLYSLK*" /label="trpA CDS" gene complement(2040921..2041724) /gene="trpA" /locus_tag="BSU_22630" /old_locus_tag="BSU22630" /label="trpA gene" promotor_-10 complement(2041409..2041428) /Source="Nicolas_upshift_promotors" /id="U1770" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.598401598401598" /psig=1 /xcortree=3019 /SigmaFactorBS="gagaaatgaaaaaaaacggagtgaatattccgattatccTCT TTACGtattataatccTGTGTTACAATTGAACAAAGaatactttttcgctttactgcg g" /listShort="hisC, tyrA, aroE, S856, S855, ypiA" /listLong="ypiB, ypiF, qcrA, qcrB, qcrC" /label="promotor_-10" upshifts complement(2041426) /Source="Nicolas_upshifts" /id="U1770" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.598401598401598" /psig=1 /xcortree=3019 /SigmaFactorBS="gagaaatgaaaaaaaacggagtgaatattccgattatccTCT TTACGtattataatccTGTGTTACAATTGAACAAAGaatactttttcgctttactgcg g" /listShort="hisC, tyrA, aroE, S856, S855, ypiA" /listLong="ypiB, ypiF, qcrA, qcrB, qcrC" /label="upshifts" promotor_-35 complement(2041440..2041447) /Source="Nicolas_upshift_promotors" /id="U1770" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.598401598401598" /psig=1 /xcortree=3019 /SigmaFactorBS="gagaaatgaaaaaaaacggagtgaatattccgattatccTCT TTACGtattataatccTGTGTTACAATTGAACAAAGaatactttttcgctttactgcg g" /listShort="hisC, tyrA, aroE, S856, S855, ypiA" /listLong="ypiB, ypiF, qcrA, qcrB, qcrC" /label="promotor_-35" CDS complement(2041717..2042919) /gene="trpB" /locus_tag="BSU_22640" /old_locus_tag="BSU22640" /EC_number="4.2.1.20" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2422155, 3062311, 9383185, 10714985, 12963367, 17114058, 17555270" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2422155, 3062311, 9383185, 10714985, 12963367, 17114058, 17555270; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tryptophan synthase (beta subunit)" /protein_id="NP_390145.2" /db_xref="EnsemblGenomes-Gn:BSU22640" /db_xref="EnsemblGenomes-Tr:CAB14180" /db_xref="GOA:P07600" /db_xref="InterPro:IPR001926" /db_xref="InterPro:IPR006653" /db_xref="InterPro:IPR006654" /db_xref="InterPro:IPR023026" /db_xref="InterPro:IPR036052" /db_xref="SubtiList:BG10290" /db_xref="UniProtKB/Swiss-Prot:P07600" /translation="MYPYPNEIGRYGDFGGKFVPETLMQPLDEIQTAFKQIKDDPAFR EEYYKLLKDYSGRPTALTYADRVTEYLGGAKIYLKREDLNHTGSHKINNALGQALLAK KMGKTKIIAETGAGQHGVAAATVAAKFGFSCTVFMGEEDVARQSLNVFRMKLLGAEVV PVTSGNGTLKDATNEAIRYWVQHCEDHFYMIGSVVGPHPYPQVVREFQKMIGEEAKDQ LKRIEGTMPDKVVACVGGGSNAMGMFQAFLNEDVELIGAEAAGKGIDTPLHAATISKG TVGVIHGSLTYLIQDEFGQIIEPYSISAGLDYPGIGPEHAYLHKSGRVTYDSITDEEA VDALKLLSEKEGILPAIESAHALAKAFKLAKGMDRGQLILVCLSGRGDKDVNTLMNVL EEEVKAHV*" /label="trpB CDS" gene complement(2041717..2042919) /gene="trpB" /locus_tag="BSU_22640" /old_locus_tag="BSU22640" /label="trpB gene" CDS complement(2042900..2043547) /gene="trpF" /locus_tag="BSU_22650" /old_locus_tag="BSU22650" /EC_number="5.3.1.24" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2422155, 9383185, 10714985, 12963367, 17114058" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2422155, 9383185, 10714985, 12963367, 17114058; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylanthranilate isomerase" /protein_id="NP_390146.3" /db_xref="EnsemblGenomes-Gn:BSU22650" /db_xref="EnsemblGenomes-Tr:CAB14181" /db_xref="GOA:P20167" /db_xref="InterPro:IPR001240" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="SubtiList:BG10289" /db_xref="UniProtKB/Swiss-Prot:P20167" /translation="MKKPALKYCGIRSLKDLQLAAESQADYLGFIFAESKRKVSPEDV KKWLNQVRVEKQVAGVFVNESIETMSRIAKSLKLDVIQLHGDEKPADAAALRKLTGCE IWKALHHQDNTTQEIARFKDNVDGFVIDSSVKGSRGGTGVAFSWECVPEYQQAAIGKR CFIAGGVNPDSITRLLKWQPEGIDLASGIEKNGQKDQNLMRLLEERMNRYVSISE*" /label="trpF CDS" gene complement(2042900..2043547) /gene="trpF" /locus_tag="BSU_22650" /old_locus_tag="BSU22650" /label="trpF gene" downshifts complement(2042994) /Source="Nicolas_upshifts" /id="D1182" /incds=1 /nref=30 /ntot=83 /MaxReadThrough="8.17917" /MaxDrop="5.75867" /score="2.96963632" /energy="-11.9" /TU="U1771,U1772,U1773,U1775" /idTUdmin="U1774" /TUdmin=616 /isTUend="FALSE" /label="downshifts" misc_feature complement(2043170..2043173) /Source="Nicolas_upshift_promotors" /id="U1771" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.394605394605395" /psig="0.041958041958042" /xcortree=2849 /SigmaFactorBS="gcttcaccatcaagataacacaactcaagaaatagcccgctt taaagataatgttgaCGGCtttgtgattgattcatctgtaaaagggtctagaggcgga a" /listShort="trpB, trpA" /listLong="hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2043170) /Source="Nicolas_upshifts" /id="U1771" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.394605394605395" /psig="0.041958041958042" /xcortree=2849 /SigmaFactorBS="gcttcaccatcaagataacacaactcaagaaatagcccgctt taaagataatgttgaCGGCtttgtgattgattcatctgtaaaagggtctagaggcgga a" /listShort="trpB, trpA" /listLong="hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="upshifts" downshifts complement(2043390) /Source="Nicolas_upshifts" /id="D1183" /incds=1 /nref=1 /ntot=84 /MaxReadThrough="8.55417" /MaxDrop="3.4408" /score="2.96963632" /energy="-11.9" /TU="U1772,U1773,U1775" /idTUdmin="U1774" /TUdmin=220 /isTUend="FALSE" /label="downshifts" misc_feature 2043552..2044304 /created_by="AR/SM" /id="IIG_Bs01" /note="due to the curing of the trpC2 locus (auxotrophy) of the Delta6 strain by transformation with chromosomal DNA from donor Bsu 3NA multiple snp`s were transferred to the oroginal trpC locus" /modified_by="User" /label="IIG_Bs01" /note="Geneious type: MiniBacillus__exchange" CDS complement(2043552..2044304) /locus_tag="PG10_trpC_var_BEP06_07765" /inference="EXISTENCE: similar to AA sequence:RefSeq:WP_007409461.1" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /codon_start=1 /transl_table=11 /product="indole-3-glycerol phosphate synthase" /protein_id="ANY35339.1" /old_locus_tag="BSU_22660" /gene="trpC" /modified_by="User" /translation="MLEKIIKQKKEEVKTLVLPVEQPFEKRSFKEALASLNRFIGLIA EVKKASPSKGLIKENFVPVRIAKDYETAKADALSVLTDTPFFQGENSYLSDVKRAVSI PVLRKDFIIDSLQVEESRRIGADAILLIGEVLDPLHLHELYLEAGEKEMDVLVEVHDA TTLEQILKVFTPDILGINNRNLKTFETSIMQTEQIASLAPKESLLVSESGIGSLEHLT FVKEHGARAVLIGESLMRQTSQRKAIHALFRE*" /label="PG10_trpC_var_BEP06_07765" gene complement(2043552..2044304) /locus_tag="PG10_trpC_var_BEP06_07765" /old_locus_tag="BSU_22660" /gene="trpC" /modified_by="User" /label="PG10_trpC_var_BEP06_07765" misc_feature complement(2043585..2043587) /Source="Nicolas_upshift_promotors" /id="U1772" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.43956043956044" /psig="0.046953046953047" /xcortree=2850 /SigmaFactorBS="tgtcaatgaacatggggcgcgagctgtacttatcggtgaatc attgatgagacaaacttctCAGcgtaaagcaatccatgctttgtttagggagtgaggt t" /listShort="trpF, trpB, trpA, hisC, tyrA, aroE, S856" /listLong="S855, ypiA, ypiB, ypiF, qcrA, qcrB" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2043588 /Source="Nicolas_upshifts" /id="U1772" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.43956043956044" /psig="0.046953046953047" /xcortree=2850 /SigmaFactorBS="tgtcaatgaacatggggcgcgagctgtacttatcggtgaatc attgatgagacaaacttctCAGcgtaaagcaatccatgctttgtttagggagtgaggt t" /listShort="trpF, trpB, trpA, hisC, tyrA, aroE, S856" /listLong="S855, ypiA, ypiB, ypiF, qcrA, qcrB" /label="upshifts" Polymorphism join(2043694,2043697) /Source="geneious" /ID="SNP_BsPG10_2374282_2374283" /Polymorphism_Type="Substitution" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=2 /Amino_Acid_Change /CDS_Position=606 /Change="AG -> GT" /Codon_Change="TCC,TTG -> TCA,CTG" /Coverage="129 -> 130" /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="AG" /Variant_Nucleotides="GT" /Variant_P_Value="2e-203" /Variant_Raw_Frequency="128 -> 129" /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(2043708,2043710) /Source="geneious" /ID="SNP_BsPG10_2374296_2374296" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change="V -> A" /CDS_Position=593 /Change="A -> G" /Codon_Change="GTT -> GCT" /Coverage=119 /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="A" /Variant_Nucleotides="G" /Variant_P_Value="3.2e-179" /Variant_Raw_Frequency=119 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(2043710,2043712) /Source="geneious" /ID="SNP_BsPG10_2374298_2374298" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=591 /Change="G -> A" /Codon_Change="CTC -> CTT" /Coverage=118 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="G" /Variant_Nucleotides="A" /Variant_P_Value="9.9e-148" /Variant_Raw_Frequency=116 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(2043735,2043737) /Source="geneious" /ID="SNP_BsPG10_2374323_2374323" /Polymorphism_Type="SNP (transversion)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change="K -> M" /CDS_Position=566 /Change="T -> A" /Codon_Change="AAG -> ATG" /Coverage=81 /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides="A" /Variant_P_Value="6.3e-98" /Variant_Raw_Frequency=81 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(2043737,2043741) /Source="geneious" /ID="SNP_BsPG10_2374325_2374327" /Polymorphism_Type="Substitution" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=2 /Amino_Acid_Change="V -> I" /CDS_Position=562 /Change="TAC -> GAT" /Codon_Change="GTA -> ATC" /Coverage="79 -> 84" /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="TAC" /Variant_Nucleotides="GAT" /Variant_P_Value="2.3e-77" /Variant_Raw_Frequency="74 -> 78" /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(2043743,2043745) /Source="geneious" /ID="SNP_BsPG10_2374331_2374331" /Polymorphism_Type="SNP (transversion)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=558 /Change="T -> G" /Codon_Change="ACA -> ACC" /Coverage=70 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides="G" /Variant_P_Value="1e-63" /Variant_Raw_Frequency=70 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(2043752,2043754) /Source="geneious" /ID="SNP_BsPG10_2374340_2374340" /Polymorphism_Type="SNP (transversion)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=549 /Change="C -> A" /Codon_Change="ACG -> ACT" /Coverage=59 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="C" /Variant_Nucleotides="A" /Variant_P_Value="1e-59" /Variant_Raw_Frequency=59 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(2043767,2043769) /Source="geneious" /ID="SNP_BsPG10_2374355_2374355" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=534 /Change="A -> G" /Codon_Change="AAT -> AAC" /Coverage=66 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="A" /Variant_Nucleotides="G" /Variant_P_Value="6e-64" /Variant_Raw_Frequency=65 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(2043770,2043772) /Source="geneious" /ID="SNP_BsPG10_2374358_2374358" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=531 /Change="A -> G" /Codon_Change="AAT -> AAC" /Coverage=63 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="A" /Variant_Nucleotides="G" /Variant_P_Value="3.3e-68" /Variant_Raw_Frequency=60 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(2043775,2043777) /Source="geneious" /ID="SNP_BsPG10_2374363_2374363" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change="V -> I" /CDS_Position=526 /Change="C -> T" /Codon_Change="GTA -> ATA" /Coverage=65 /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value="3.9e-82" /Variant_Raw_Frequency=64 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(2043785,2043787) /Source="geneious" /ID="SNP_BsPG10_2374373_2374373" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=516 /Change="G -> A" /Codon_Change="GAC -> GAT" /Coverage=79 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="G" /Variant_Nucleotides="A" /Variant_P_Value="7.7e-116" /Variant_Raw_Frequency=78 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(2043788,2043790) /Source="geneious" /ID="SNP_BsPG10_2374376_2374376" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=513 /Change="G -> A" /Codon_Change="CCC -> CCT" /Coverage=92 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="G" /Variant_Nucleotides="A" /Variant_P_Value="4e-141" /Variant_Raw_Frequency=90 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(2043791,2043793) /Source="geneious" /ID="SNP_BsPG10_2374379_2374379" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=510 /Change="T -> C" /Codon_Change="ACA -> ACG" /Coverage=97 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides="C" /Variant_P_Value="1.3e-165" /Variant_Raw_Frequency=97 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(2043797,2043799) /Source="geneious" /ID="SNP_BsPG10_2374385_2374385" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=504 /Change="C -> T" /Codon_Change="GTG -> GTA" /Coverage=109 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value="4.3e-193" /Variant_Raw_Frequency=108 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(2043823,2043825) /Source="geneious" /ID="SNP_BsPG10_2374411_2374411" /Polymorphism_Type="SNP (transversion)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change="S -> T" /CDS_Position=478 /Change="A -> T" /Codon_Change="TCA -> ACA" /Coverage=148 /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="A" /Variant_Nucleotides="T" /Variant_P_Value="2.9e-307" /Variant_Raw_Frequency=147 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(2043855,2043857) /Source="geneious" /ID="SNP_BsPG10_2374443_2374443" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change="G -> E" /CDS_Position=446 /Change="C -> T" /Codon_Change="GGG -> GAG" /Coverage=161 /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=161 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(2043908,2043910) /Source="geneious" /ID="SNP_BsPG10_2374496_2374496" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=393 /Change="C -> T" /Codon_Change="GAG -> GAA" /Coverage=174 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=174 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(2043956,2043958) /Source="geneious" /ID="SNP_BsPG10_2374544_2374544" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=345 /Change="T -> C" /Codon_Change="GTA -> GTG" /Coverage=168 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides="C" /Variant_P_Value=0 /Variant_Raw_Frequency=167 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(2043971,2043975) /Source="geneious" /ID="SNP_BsPG10_2374559_2374558" /Polymorphism_Type="Insertion" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=0 /Amino_Acid_Change="-> I" /CDS_Position=331 /Change="AAT" /Codon_Change="-> ATT" /Coverage=164 /locus_tag="BSU_22660" /Protein_Effect="Insertion" /Reference_Frequency /Reference_Nucleotides /Variant_Nucleotides="AAT" /Variant_P_Value="3.90000001038273e-316" /Variant_Raw_Frequency=147 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(2043989,2043991) /Source="geneious" /ID="SNP_BsPG10_2374574_2374574" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=315 /Change="A -> G" /Codon_Change="CTT -> CTC" /Coverage=155 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="A" /Variant_Nucleotides="G" /Variant_P_Value=0 /Variant_Raw_Frequency=154 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(2043998,2044000) /Source="geneious" /ID="SNP_BsPG10_2374583_2374583" /Polymorphism_Type="SNP (transversion)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=306 /Change="A -> T" /Codon_Change="ATT -> ATA" /Coverage=153 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="A" /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=152 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(2044010,2044012) /Source="geneious" /ID="SNP_BsPG10_2374595_2374595" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=294 /Change="A -> G" /Codon_Change="CGT -> CGC" /Coverage=128 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="A" /Variant_Nucleotides="G" /Variant_P_Value="4e-295" /Variant_Raw_Frequency=128 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(2044075,2044077) /Source="geneious" /ID="SNP_BsPG10_2374660_2374660" /Polymorphism_Type="SNP (transversion)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change="I -> L" /CDS_Position=229 /Change="T -> G" /Codon_Change="ATT -> CTT" /Coverage=131 /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides="G" /Variant_P_Value="2.3e-302" /Variant_Raw_Frequency=128 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(2044085,2044087) /Source="geneious" /ID="SNP_BsPG10_2374670_2374670" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=219 /Change="C -> T" /Codon_Change="AAG -> AAA" /Coverage=126 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value="1.6e-290" /Variant_Raw_Frequency=126 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(2044093,2044096) /Source="geneious" /ID="SNP_BsPG10_2374678_2374679" /Polymorphism_Type="Substitution" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=2 /Amino_Acid_Change="EA -> ET" /CDS_Position=210 /Change="CC -> TT" /Codon_Change="GAG,GCT -> GAA,ACT" /Coverage="124 -> 130" /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="CC" /Variant_Nucleotides="TT" /Variant_P_Value="4.7e-253" /Variant_Raw_Frequency="119 -> 125" /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(2044113,2044115) /Source="geneious" /ID="SNP_BsPG10_2374698_2374698" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change="Q -> R" /CDS_Position=191 /Change="T -> C" /Codon_Change="CAG -> CGG" /Coverage=104 /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides="C" /Variant_P_Value="9e-228" /Variant_Raw_Frequency=101 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(2044129,2044131) /Source="geneious" /ID="SNP_BsPG10_2374714_2374714" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change="D -> N" /CDS_Position=175 /Change="C -> T" /Codon_Change="GAT -> AAT" /Coverage=95 /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency="1.1%" /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value="2.8e-220" /Variant_Raw_Frequency=93 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(2044157,2044159) /Source="geneious" /ID="SNP_BsPG10_2374742_2374742" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=147 /Change="T -> C" /Codon_Change="GCA -> GCG" /Coverage=98 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides="C" /Variant_P_Value="1.2e-260" /Variant_Raw_Frequency=97 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(2044172,2044174) /Source="geneious" /ID="SNP_BsPG10_2374757_2374757" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=132 /Change="G -> A" /Codon_Change="GCC -> GCT" /Coverage=197 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="G" /Variant_Nucleotides="A" /Variant_P_Value /Variant_Raw_Frequency /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(2044197,2044199) /Source="geneious" /ID="SNP_BsPG10_2374782_2374782" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change="P -> L" /CDS_Position=107 /Change="G -> A" /Codon_Change="CCG -> CTG" /Coverage=118 /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="G" /Variant_Nucleotides="A" /Variant_P_Value=0 /Variant_Raw_Frequency=118 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(2044214,2044216) /Source="geneious" /ID="SNP_BsPG10_2374799_2374799" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=90 /Change="C -> T" /Codon_Change="AAG -> AAA" /Coverage=133 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=131 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(2044229,2044231) /Source="geneious" /ID="SNP_BsPG10_2374814_2374814" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=75 /Change="C -> T" /Codon_Change="GAG -> GAA" /Coverage=130 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=130 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" CDS complement(2044297..2045313) /gene="trpD" /locus_tag="BSU_22670" /old_locus_tag="BSU22670" /EC_number="2.4.2.18" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2422155, 9383185, 17555270, 10714985, 12963367, 17114058" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2422155, 9383185, 17555270, 10714985, 12963367, 17114058; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="anthranilate phosphoribosyltransferase" /protein_id="NP_390148.2" /db_xref="EnsemblGenomes-Gn:BSU22670" /db_xref="EnsemblGenomes-Tr:CAB14183" /db_xref="GOA:P03947" /db_xref="InterPro:IPR000312" /db_xref="InterPro:IPR005940" /db_xref="InterPro:IPR017459" /db_xref="InterPro:IPR035902" /db_xref="InterPro:IPR036320" /db_xref="SubtiList:BG10288" /db_xref="UniProtKB/Swiss-Prot:P03947" /modified_by="User" /translation="MNRFLQLCVDGKTLTAGEAETLMNMMMAAEMTPSEMGGILSILA HRGETPEELAGFVKAMRAHALTVDGLPDIVDTCGTGGDGISTFNISTASAIVASAAGA KIAKHGNRSVSSKSGSADVLEELEVSIQTTPEKVKSSIETNNMGFLFAPLYHSSMKHV AGTRKELGFRTVFNLLGPLSNPLQAKRQVIGVYSVEKAGLMASALETFQPKHVMFVSS RDGLDELSITAPTDVIELKDGERREYTVSPEDFGFTNGRLEDLQVQSPKESAYLIQNI FENKSSSSALSITAFNAGAAIYTAGITASLKEGTELALETITSGGAAAQLERLKQKEE EIYA*" /label="trpD CDS" gene complement(2044297..2045313) /gene="trpD" /locus_tag="BSU_22670" /old_locus_tag="BSU22670" /modified_by="User" /label="trpD gene" CDS complement(2045285..2046832) /gene="trpE" /locus_tag="BSU_22680" /old_locus_tag="BSU22680" /EC_number="4.1.3.27" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2422155, 9383185, 17555270, 10714985, 12963367, 15063849, 17114058" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2422155, 9383185, 17555270, 10714985, 12963367, 15063849, 17114058; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="anthranilate synthase" /protein_id="NP_390149.1" /db_xref="EnsemblGenomes-Gn:BSU22680" /db_xref="EnsemblGenomes-Tr:CAB14184" /db_xref="GOA:P03963" /db_xref="InterPro:IPR005256" /db_xref="InterPro:IPR005801" /db_xref="InterPro:IPR006805" /db_xref="InterPro:IPR015890" /db_xref="InterPro:IPR019999" /db_xref="SubtiList:BG10287" /db_xref="UniProtKB/Swiss-Prot:P03963" /translation="MNFQSNISAFLEDSLSHHTIPIVETFTVDTLTPIQMIEKLDREI TYLLESKDDTSTWSRYSFIGLNPFLTIKEEQGRFSAADQDSKSLYTGNELKEVLNWMN TTYKIKTPELGIPFVGGAVGYLSYDMIPLIEPSVPSHTKETDMEKCMLFVCRTLIAYD HETKNVHFIQYARLTGEETKNEKMDVFHQNHLELQNLIEKMMDQKNIKELFLSADSYK TPSFETVSSNYEKSAFMADVEKIKSYIKAGDIFQGVLSQKFEVPIKADAFELYRVLRI VNPSPYMYYMKLLDREIVGSSPERLIHVQDGHLEIHPIAGTRKRGADKAEDERLKVEL MKDEKEKAEHYMLVDLARNDIGRVAEYGSVSVPEFTKIVSFSHVMHIISVVTGRLKKG VHPVDALMSAFPAGTLTGAPKIRAMQLLQELEPTPRETYGGCIAYIGFDGNIDSCITI RTMSVKNGVASIQAGAGIVADSVPEAEYEESCNKAGALLKTIHIAEDMFHSKEDKADE QISTIVR*" /label="trpE CDS" gene complement(2045285..2046832) /gene="trpE" /locus_tag="BSU_22680" /old_locus_tag="BSU22680" /label="trpE gene" S_feature complement(2046911..2047042) /Source="Nicolas_S_feature" /locus_tag="new_2377495_2377626_c" /HighExp="Etha, S1, GM 25, GM 15, HiTm, Glu, MG-0.1, GM 60, M9-exp, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY, SigA, SigA, SigA" /TUshortPSig="0.994, 0.647, 0.999, 1, 0.996" /TUlongSig="SigA, SigA, SigA" /TUlongPSig="0.999, 1, 0.998" /label="S857" downshifts complement(2046954) /Source="Nicolas_upshifts" /id="D1184" /incds=0 /nref=61 /ntot=157 /MaxReadThrough="7.41666" /MaxDrop="5.25158" /score="2.96963632" /energy="-11.9" /TU="U1773,U1774,U1775,U1776" /idTUdmin="U1777" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2047033..2047052) /Source="Nicolas_upshift_promotors" /id="U1773" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.52047952047952" /psig="0.994005994005994" /xcortree=401 /SigmaFactorBS="aaaagttgtcgtattgaggcccgatttaTCATTGACaaaaaa tactgaatTGTAATACGATAAGAACAGCttagaaatacacaagagtgtgtataaagca a" /listShort="S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856" /listLong="S855, ypiA, ypiB, ypiF, qcrA, qcrB" /label="promotor_-10" upshifts complement(2047042) /Source="Nicolas_upshifts" /id="U1773" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.52047952047952" /psig="0.994005994005994" /xcortree=401 /SigmaFactorBS="aaaagttgtcgtattgaggcccgatttaTCATTGACaaaaaa tactgaatTGTAATACGATAAGAACAGCttagaaatacacaagagtgtgtataaagca a" /listShort="S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856" /listLong="S855, ypiA, ypiB, ypiF, qcrA, qcrB" /label="upshifts" CDS complement(2047048..2047431) /gene="aroH" /locus_tag="BSU_22690" /old_locus_tag="BSU22690" /EC_number="5.4.99.5" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2105742, 8378335, 9384560, 10818343, 15865424, 16060652, 28743924" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2105742, 8378335, 9384560, 10818343, 15865424, 16060652, 28743924; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="chorismate mutase" /protein_id="NP_390150.1" /db_xref="EnsemblGenomes-Gn:BSU22690" /db_xref="EnsemblGenomes-Tr:CAB14185" /db_xref="GOA:P19080" /db_xref="InterPro:IPR008243" /db_xref="InterPro:IPR035959" /db_xref="PDB:1COM" /db_xref="PDB:1DBF" /db_xref="PDB:1FNJ" /db_xref="PDB:1FNK" /db_xref="PDB:2CHS" /db_xref="PDB:2CHT" /db_xref="PDB:3ZO8" /db_xref="PDB:3ZOP" /db_xref="PDB:3ZP4" /db_xref="PDB:3ZP7" /db_xref="SubtiList:BG10286" /db_xref="UniProtKB/Swiss-Prot:P19080" /translation="MMIRGIRGATTVERDTEEEILQKTKQLLEKIIEENHTKPEDVVQ MLLSATPDLHAVFPAKAVRELSGWQYVPVTCMQEMDVTGGLKKCIRVMMTVQTDVPQD QIRHVYLEKVVVLRPDLSLTKNTEL*" /label="aroH CDS" gene complement(2047048..2047431) /gene="aroH" /locus_tag="BSU_22690" /old_locus_tag="BSU22690" /label="aroH gene" promotor_-35 complement(2047067..2047074) /Source="Nicolas_upshift_promotors" /id="U1773" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.52047952047952" /psig="0.994005994005994" /xcortree=401 /SigmaFactorBS="aaaagttgtcgtattgaggcccgatttaTCATTGACaaaaaa tactgaatTGTAATACGATAAGAACAGCttagaaatacacaagagtgtgtataaagca a" /listShort="S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856" /listLong="S855, ypiA, ypiB, ypiF, qcrA, qcrB" /label="promotor_-35" CDS complement(2047428..2048516) /gene="aroB" /locus_tag="BSU_22700" /old_locus_tag="BSU22700" /EC_number="4.2.3.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:97285, 97286, 6795181, 24628944" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 97285, 97286, 6795181, 24628944; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-dehydroquinate synthase" /protein_id="NP_390151.1" /db_xref="EnsemblGenomes-Gn:BSU22700" /db_xref="EnsemblGenomes-Tr:CAB14186" /db_xref="GOA:P31102" /db_xref="InterPro:IPR016037" /db_xref="InterPro:IPR030960" /db_xref="InterPro:IPR030963" /db_xref="SubtiList:BG10285" /db_xref="UniProtKB/Swiss-Prot:P31102" /translation="MKTLHVQTASSSYPVFIGQGIRKKACELLTSLNRPLTRIMFVTD EEVDRLYGDEMLHLLQEKWPVKKVTVPSGEQAKSMDMYTKLQSEAIRFHMDRSSCIIA FGGGVVGDLAGFVAATFMRGIDFIQMPTTLLAHDSAVGGKVAVNHPLGKNLIGAFYQP KAVLYDTDFLRSLPEKELRSGMAEVIKHAFIYDRAFLEELLNIHSLRDITNDQLNDMI FKGISIKASVVQQDEKEEGIRAYLNFGHTLGHAVEAEYGYGQITHGDAVALGMQFALY ISEKTVGCEMDRKRLVSWLKSLGYPSQIRKETETSVLLNRMMNDKKTRGGKIQFIVLN ELGKVADHTFSRNELESWLNKWRLEETS*" /label="aroB CDS" gene complement(2047428..2048516) /gene="aroB" /locus_tag="BSU_22700" /old_locus_tag="BSU22700" /label="aroB gene" promotor_-10 complement(2047557..2047572) /Source="Nicolas_upshift_promotors" /id="U1774" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.647352647352647" /psig="0.647352647352647" /xcortree=1460 /SigmaFactorBS="aaagcctgggttatccaagtcaaatcagaaaagagacGGAAA CTTCggttctcttgaaCCGTATGATGAATGATaagaaaacccgtggcgggaagattca g" /listShort="aroH, S857, trpE, trpD, trpC" /listLong="trpF, trpB, trpA, hisC, tyrA, aroE" /label="promotor_-10" upshifts complement(2047570) /Source="Nicolas_upshifts" /id="U1774" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.647352647352647" /psig="0.647352647352647" /xcortree=1460 /SigmaFactorBS="aaagcctgggttatccaagtcaaatcagaaaagagacGGAAA CTTCggttctcttgaaCCGTATGATGAATGATaagaaaacccgtggcgggaagattca g" /listShort="aroH, S857, trpE, trpD, trpC" /listLong="trpF, trpB, trpA, hisC, tyrA, aroE" /label="upshifts" promotor_-35 complement(2047585..2047593) /Source="Nicolas_upshift_promotors" /id="U1774" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.647352647352647" /psig="0.647352647352647" /xcortree=1460 /SigmaFactorBS="aaagcctgggttatccaagtcaaatcagaaaagagacGGAAA CTTCggttctcttgaaCCGTATGATGAATGATaagaaaacccgtggcgggaagattca g" /listShort="aroH, S857, trpE, trpD, trpC" /listLong="trpF, trpB, trpA, hisC, tyrA, aroE" /label="promotor_-35" CDS complement(2048516..2049688) /gene="aroF" /locus_tag="BSU_22710" /old_locus_tag="BSU22710" /EC_number="4.2.3.5" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:97285, 97286, 6795181, 10518299, 24628944" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 97285, 97286, 6795181, 10518299, 24628944; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="chorismate synthase" /protein_id="NP_390152.3" /db_xref="EnsemblGenomes-Gn:BSU22710" /db_xref="EnsemblGenomes-Tr:CAB14187" /db_xref="GOA:P31104" /db_xref="InterPro:IPR000453" /db_xref="InterPro:IPR020541" /db_xref="InterPro:IPR035904" /db_xref="SubtiList:BG10284" /db_xref="UniProtKB/Swiss-Prot:P31104" /translation="MRYLTAGESHGPQLTTIIEGVPAGLYITEEDINFELARRQKGHG RGRRMQIEKDQAKIMSGVRHARTLGSPIALVVENNDWKHWTKIMGAAPITEDEEKEMK RQISRPRPGHADLNGAIKYNHRDMRNVLERSSARETTVRVAAGAVAKKILSELGIKVA GHVLQIGAVKAEKTEYTSIEDLQRVTEESPVRCYDEEAGKKMMAAIDEAKANGDSIGG IVEVIVEGMPVGVGSYVHYDRKLDSKLAAAVLSINAFKGVEFGIGFEAAGRNGSEVHD EIIWDEEKGYTRATNRLGGLEGGMTTGMPIVVRGVMKPIPTLYKPLKSVDIETKEPFS ASIERSDSCAVPAASVVAEAAVAWEIANAVVEQFGLDQIDRIRENVENMRKLSREF*" /label="aroF CDS" gene complement(2048516..2049688) /gene="aroF" /locus_tag="BSU_22710" /old_locus_tag="BSU22710" /label="aroF gene" promotor_-10 complement(2049723..2049742) /Source="Nicolas_upshift_promotors" /id="U1775" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.607392607392607" /psig="0.999000999001" /xcortree=3020 /SigmaFactorBS="tagtcccagccgatacattcttttatcaaaaaagatagACTG ACTTtttgctgaaaaaTATGTTATAGTAGTCTTACTtaaaagcgttaatgcgatgaag g" /listShort="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE" /listLong="S856, S855, ypiA, ypiB, ypiF" /label="promotor_-10" upshifts complement(2049740) /Source="Nicolas_upshifts" /id="U1775" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.607392607392607" /psig="0.999000999001" /xcortree=3020 /SigmaFactorBS="tagtcccagccgatacattcttttatcaaaaaagatagACTG ACTTtttgctgaaaaaTATGTTATAGTAGTCTTACTtaaaagcgttaatgcgatgaag g" /listShort="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE" /listLong="S856, S855, ypiA, ypiB, ypiF" /label="upshifts" promotor_-35 complement(2049755..2049762) /Source="Nicolas_upshift_promotors" /id="U1775" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.607392607392607" /psig="0.999000999001" /xcortree=3020 /SigmaFactorBS="tagtcccagccgatacattcttttatcaaaaaagatagACTG ACTTtttgctgaaaaaTATGTTATAGTAGTCTTACTtaaaagcgttaatgcgatgaag g" /listShort="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE" /listLong="S856, S855, ypiA, ypiB, ypiF" /label="promotor_-35" CDS complement(2049763..2050533) /gene="cheR" /locus_tag="BSU_22720" /old_locus_tag="BSU22720" /EC_number="2.1.1.80" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:7635819, 7893679, 8244966, 10196193, 15544802, 25799883, 27544050" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7635819, 7893679, 8244966, 10196193, 15544802, 25799883, 27544050; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methyl-accepting chemotaxis proteins (MCPs) methyltransferase" /protein_id="NP_390153.2" /db_xref="EnsemblGenomes-Gn:BSU22720" /db_xref="EnsemblGenomes-Tr:CAB14188" /db_xref="GOA:P31105" /db_xref="InterPro:IPR000780" /db_xref="InterPro:IPR022641" /db_xref="InterPro:IPR022642" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR036804" /db_xref="PDB:5FTW" /db_xref="SubtiList:BG10283" /db_xref="UniProtKB/Swiss-Prot:P31105" /translation="MDTYSVFTTKWKQLTGVDLTLYKEAQMKRRLTSLYEKKGFQSFK DFAAALEKDQALLNETLDRMTINVSEFYRNYKRWEVLETAILPLIKTSRPLKIWSAAC STGEEPYTLAMLLDQQKGLPGYQILATDIDEKALEKAKKGVYQERSLQEVPLSVKDRY FTQNANRSYEVKTEIKKNITFKKHNLLADRYEQDFDLIVCRNVFIYFTESAKEELYLK MAHSLKKNGVLFVGSTEQIFNPEKFGLVPADTFFYQKR*" /label="cheR CDS" gene complement(2049763..2050533) /gene="cheR" /locus_tag="BSU_22720" /old_locus_tag="BSU22720" /label="cheR gene" promotor_-10 complement(2050559..2050578) /Source="Nicolas_upshift_promotors" /id="U1776" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.821178821178821" /psig=1 /xcortree=3061 /SigmaFactorBS="tctaaaatcagctgaaaagctgatttttttattgaaacaaTA CAATTtcctgataaaaCAAGCTATACTAGGACAAAAagacagcgagactgggagagta g" /listShort="cheR, aroF, aroB, aroH, S857, trpE, trpD" /listLong="trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-10" upshifts complement(2050576) /Source="Nicolas_upshifts" /id="U1776" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.821178821178821" /psig=1 /xcortree=3061 /SigmaFactorBS="tctaaaatcagctgaaaagctgatttttttattgaaacaaTA CAATTtcctgataaaaCAAGCTATACTAGGACAAAAagacagcgagactgggagagta g" /listShort="cheR, aroF, aroB, aroH, S857, trpE, trpD" /listLong="trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="upshifts" promotor_-35 complement(2050590..2050596) /Source="Nicolas_upshift_promotors" /id="U1776" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.821178821178821" /psig=1 /xcortree=3061 /SigmaFactorBS="tctaaaatcagctgaaaagctgatttttttattgaaacaaTA CAATTtcctgataaaaCAAGCTATACTAGGACAAAAagacagcgagactgggagagta g" /listShort="cheR, aroF, aroB, aroH, S857, trpE, trpD" /listLong="trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-35" S_feature complement(2050608..2050769) /Source="Nicolas_S_feature" /locus_tag="new_2381192_2381353_c" /HighExp="M0t90, Lbstat, S0, Mt0, M0t45, M40t90, Lbtran, Mal, G/S, MG-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="0.996, 0.999, 1, 0.998" /TUlongSig="SigEF" /TUlongPSig=1 /label="S858" downshifts complement(2050651) /Source="Nicolas_upshifts" /id="D1185" /incds=0 /nref=26 /ntot=128 /MaxReadThrough="4.04342" /MaxDrop="4.7493" /score="29.2259705" /energy="-8.6" /TU="U1777,U1778,U1779,U1780" /idTUdmin="U1778" /TUdmin="-880" /isTUend="FALSE" /label="downshifts" CDS complement(2050770..2051219) /gene="ndk" /locus_tag="BSU_22730" /old_locus_tag="BSU22730" /EC_number="2.7.4.6" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9179491, 11734624, 22720735, 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nucleoside diphosphate kinase" /protein_id="NP_390154.1" /db_xref="EnsemblGenomes-Gn:BSU22730" /db_xref="EnsemblGenomes-Tr:CAB14189" /db_xref="GOA:P31103" /db_xref="InterPro:IPR001564" /db_xref="InterPro:IPR023005" /db_xref="InterPro:IPR034907" /db_xref="InterPro:IPR036850" /db_xref="SubtiList:BG10282" /db_xref="UniProtKB/Swiss-Prot:P31103" /translation="MMEKTFIMVKPDGVQRQLIGDILSRFERKGLQLAGAKLMRVTEQ MAEKHYAEHQGKPFFGELVEFITSGPVFAMVWEGENVIEVTRQLIGKTNPKEALPGTI RGDYGMFVGKNIIHGSDSLESAEREINIFFKNEELVSYQQLMAGWIY*" /label="ndk CDS" gene complement(2050770..2051219) /gene="ndk" /locus_tag="BSU_22730" /old_locus_tag="BSU22730" /label="ndk gene" promotor_-10 complement(2051262..2051281) /Source="Nicolas_upshift_promotors" /id="U1777" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig="0.996003996003996" /xcortree=1593 /SigmaFactorBS="gtagatattaagaaatttctccgccccgGATTGATTaattat cagaaaGATGTTACGATTTCGGTGTGcagtgtgaaagcctatacatacataatgatgg g" /listShort="ndk, S858, cheR, aroF, aroB, aroH, S857" /listLong="trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE" /label="promotor_-10" upshifts complement(2051269) /Source="Nicolas_upshifts" /id="U1777" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig="0.996003996003996" /xcortree=1593 /SigmaFactorBS="gtagatattaagaaatttctccgccccgGATTGATTaattat cagaaaGATGTTACGATTTCGGTGTGcagtgtgaaagcctatacatacataatgatgg g" /listShort="ndk, S858, cheR, aroF, aroB, aroH, S857" /listLong="trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE" /label="upshifts" promotor_-35 complement(2051294..2051301) /Source="Nicolas_upshift_promotors" /id="U1777" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig="0.996003996003996" /xcortree=1593 /SigmaFactorBS="gtagatattaagaaatttctccgccccgGATTGATTaattat cagaaaGATGTTACGATTTCGGTGTGcagtgtgaaagcctatacatacataatgatgg g" /listShort="ndk, S858, cheR, aroF, aroB, aroH, S857" /listLong="trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE" /label="promotor_-35" CDS complement(2051335..2052381) /gene="hepT" /locus_tag="BSU_22740" /old_locus_tag="BSU22740" /EC_number="2.5.1.30" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6768722, 9139683, 9720033, 9756625, 10545188, 23840410" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6768722, 9139683, 9720033, 9756625, 10545188, 23840410; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="heptaprenyl diphosphate synthase component II" /protein_id="NP_390155.1" /db_xref="EnsemblGenomes-Gn:BSU22740" /db_xref="EnsemblGenomes-Tr:CAB14190" /db_xref="GOA:P31114" /db_xref="InterPro:IPR000092" /db_xref="InterPro:IPR008949" /db_xref="InterPro:IPR014119" /db_xref="InterPro:IPR033749" /db_xref="SubtiList:BG10281" /db_xref="UniProtKB/Swiss-Prot:P31114" /translation="MLNIIRLLAESLPRISDGNENTDVWVNDMKFKMAYSFLNDDIDV IERELEQTVRSDYPLLSEAGLHLLQAGGKRIRPVFVLLSGMFGDYDINKIKYVAVTLE MIHMASLVHDDVIDDAELRRGKPTIKAKWDNRIAMYTGDYMLAGSLEMMTRINEPKAH RILSQTIVEVCLGEIEQIKDKYNMEQNLRTYLRRIKRKTALLIAVSCQLGAIASGADE KIHKALYWFGYYVGMSYQIIDDILDFTSTEEELGKPVGGDLLQGNVTLPVLYALKNPA LKNQLKLINSETTQEQLEPIIEEIKKTDAIEASMAVSEMYLQKAFQKLNTLPRGRARS SLAAIAKYIGKRKF*" /label="hepT CDS" gene complement(2051335..2052381) /gene="hepT" /locus_tag="BSU_22740" /old_locus_tag="BSU22740" /label="hepT gene" CDS complement(2052323..2053024) /gene="menG" /locus_tag="BSU_22750" /old_locus_tag="BSU22750" /EC_number="2.1.1.163" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:16279806, 9045837, 9139683, 21513522, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16279806, 9045837, 9139683, 21513522, 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="demethylmenaquinone methyltransferase" /protein_id="NP_390156.1" /db_xref="EnsemblGenomes-Gn:BSU22750" /db_xref="EnsemblGenomes-Tr:CAB14191" /db_xref="GOA:P31113" /db_xref="InterPro:IPR004033" /db_xref="InterPro:IPR014122" /db_xref="InterPro:IPR023576" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG10280" /db_xref="UniProtKB/Swiss-Prot:P31113" /translation="MQDSKEQRVHGVFEKIYKNYDQMNSVISFQQHKKWRDKTMRIMN VKEGAKALDVCCGTADWTIALAKAAGKSGEIKGLDFSENMLSVGEQKVKDGGFSQIEL LHGNAMELPFDDDTFDYVTIGFGLRNVPDYLTVLKEMRRVVKPGGQVVCLETSQPEMF GFRQAYFMYFKYIMPFFGKLFAKSYKEYSWLQESARDFPGMKELAGLFEEAGLKNVKY HSFTGGVAATHIGWK*" /label="menG CDS" gene complement(2052323..2053024) /gene="menG" /locus_tag="BSU_22750" /old_locus_tag="BSU22750" /label="menG gene" CDS complement(2053031..2053786) /gene="hepS" /locus_tag="BSU_22760" /old_locus_tag="BSU22760" /EC_number="2.5.1.30" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:6768722, 9139683, 9720033, 9756625, 10545188, 23840410" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6768722, 9139683, 9720033, 9756625, 10545188, 23840410; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="heptaprenyl diphosphate synthase component I" /protein_id="NP_390157.1" /db_xref="EnsemblGenomes-Gn:BSU22760" /db_xref="EnsemblGenomes-Tr:CAB14192" /db_xref="GOA:P31112" /db_xref="InterPro:IPR009920" /db_xref="SubtiList:BG10279" /db_xref="UniProtKB/Swiss-Prot:P31112" /translation="MQDIYGTLANLNTKLKQKLSHPYLAKHISAPKIDEDKLLLFHAL FEEADIKNNDRENYIVTAMLVQSALDTHDEVTTARVIKRDENKNRQLTVLAGDYFSGL YYSLLSEMKDIYMIRTLATAIKEINEHKIRLYDRSFKDENDFFESVGIVESALFHRVA EHFNLPRWKKLSSDFFVFKRLMNGNDAFLDVIGSFIQLGKTKEEILEDCFKKAKNSIE SLLPLNSPIQNILINRLKTISQDQTYHQKVEEG*" /label="hepS CDS" gene complement(2053031..2053786) /gene="hepS" /locus_tag="BSU_22760" /old_locus_tag="BSU22760" /label="hepS gene" S_feature complement(2053787..2053872) /Source="Nicolas_S_feature" /locus_tag="new_2384371_2384456_c" /HighExp="H2O2, G150, G180, Paraq, Oxctl, G135, T-4.40H, Lbexp, T-3.40H, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.999, 1, 0.998" /TUlongSig="SigEF" /TUlongPSig=1 /label="S859" promotor_-10 complement(2053861..2053880) /Source="Nicolas_upshift_promotors" /id="U1778" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.919080919080919" /psig="0.999000999001" /xcortree=2333 /SigmaFactorBS="ttaaaagcaaatgctcgcaaacagcgggaggataCAGCCAAT ttctttttttTATGCTATAATGATACCTGCgtaagcgaatgaaaagataaaactcata c" /listShort="S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-10" upshifts complement(2053872) /Source="Nicolas_upshifts" /id="U1778" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.919080919080919" /psig="0.999000999001" /xcortree=2333 /SigmaFactorBS="ttaaaagcaaatgctcgcaaacagcgggaggataCAGCCAAT ttctttttttTATGCTATAATGATACCTGCgtaagcgaatgaaaagataaaactcata c" /listShort="S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="upshifts" promotor_-35 complement(2053891..2053898) /Source="Nicolas_upshift_promotors" /id="U1778" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.919080919080919" /psig="0.999000999001" /xcortree=2333 /SigmaFactorBS="ttaaaagcaaatgctcgcaaacagcgggaggataCAGCCAAT ttctttttttTATGCTATAATGATACCTGCgtaagcgaatgaaaagataaaactcata c" /listShort="S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-35" CDS complement(2053950..2054177) /gene="mtrB" /locus_tag="BSU_22770" /old_locus_tag="BSU22770" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15099736, 15588817, 16285852, 16306262, 17114058, 28069823" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15099736, 15588817, 16285852, 16306262, 17114058, 28069823; Product type r : regulator" /codon_start=1 /transl_table=11 /product="tryptophan operon RNA-binding attenuation protein (TRAP)" /protein_id="NP_390158.1" /db_xref="EnsemblGenomes-Gn:BSU22770" /db_xref="EnsemblGenomes-Tr:CAB14193" /db_xref="GOA:P19466" /db_xref="InterPro:IPR000824" /db_xref="InterPro:IPR016031" /db_xref="InterPro:IPR023558" /db_xref="PDB:1WAP" /db_xref="PDB:3ZZQ" /db_xref="PDB:4B27" /db_xref="SubtiList:BG10278" /db_xref="UniProtKB/Swiss-Prot:P19466" /translation="MNQKHSSDFVVIKAVEDGVNVIGLTRGTDTKFHHSEKLDKGEVI IAQFTEHTSAIKVRGEALIQTAYGEMKSEKK*" /label="mtrB CDS" gene complement(2053950..2054177) /gene="mtrB" /locus_tag="BSU_22770" /old_locus_tag="BSU22770" /label="mtrB gene" downshifts complement(2053971) /Source="Nicolas_upshifts" /id="D1186" /incds=0 /nref=22 /ntot=162 /MaxReadThrough="6.02348" /MaxDrop="4.385" /score="8.50521108" /energy="-10.5" /TU="U1779,U1780" /idTUdmin="U1781" /TUdmin=1499 /isTUend="FALSE" /label="downshifts" CDS complement(2054199..2054771) /gene="folEA" /locus_tag="BSU_22780" /old_locus_tag="BSU22780" /EC_number="3.5.4.16" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1551827, 12559918, 14717702, 17032654" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1551827, 12559918, 14717702, 17032654; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GTP cyclohydrolase I" /protein_id="NP_390159.1" /db_xref="EnsemblGenomes-Gn:BSU22780" /db_xref="EnsemblGenomes-Tr:CAB14194" /db_xref="GOA:P19465" /db_xref="InterPro:IPR001474" /db_xref="InterPro:IPR018234" /db_xref="InterPro:IPR020602" /db_xref="SubtiList:BG10277" /db_xref="UniProtKB/Swiss-Prot:P19465" /translation="MKEVNKEQIEQAVRQILEAIGEDPNREGLLDTPKRVAKMYAEVF SGLNEDPKEHFQTIFGENHEELVLVKDIAFHSMCEHHLVPFYGKAHVAYIPRGGKVTG LSKLARAVEAVAKRPQLQERITSTIAESIVETLDPHGVMVVVEAEHMCMTMRGVRKPG AKTVTSAVRGVFKDDAAARAEVLEHIKRQD*" /label="folEA CDS" gene complement(2054199..2054771) /gene="folEA" /locus_tag="BSU_22780" /old_locus_tag="BSU22780" /label="folEA gene" promotor_-10 complement(2054800..2054819) /Source="Nicolas_upshift_promotors" /id="U1779" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.841158841158841" /psig=1 /xcortree=1869 /SigmaFactorBS="aagagcatgggcttcctgacagggcattcactTTGCTTTtag cggggcataTGTGCTAGAATCGAAATTAAatgtattcattggtggaggacatagaaca t" /listShort="folEA, mtrB, S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-10" upshifts complement(2054810) /Source="Nicolas_upshifts" /id="U1779" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.841158841158841" /psig=1 /xcortree=1869 /SigmaFactorBS="aagagcatgggcttcctgacagggcattcactTTGCTTTtag cggggcataTGTGCTAGAATCGAAATTAAatgtattcattggtggaggacatagaaca t" /listShort="folEA, mtrB, S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="upshifts" S_feature complement(2054812..2054895) /Source="Nicolas_S_feature" /locus_tag="new_2385396_2385479_c" /HighExp="Oxctl, G150, G180, G135, LBGexp, Paraq, LPh, H2O2, aero, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="SigEF" /TUlongPSig=1 /label="S860" promotor_-35 complement(2054832..2054838) /Source="Nicolas_upshift_promotors" /id="U1779" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.841158841158841" /psig=1 /xcortree=1869 /SigmaFactorBS="aagagcatgggcttcctgacagggcattcactTTGCTTTtag cggggcataTGTGCTAGAATCGAAATTAAatgtattcattggtggaggacatagaaca t" /listShort="folEA, mtrB, S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-35" downshifts complement(2054940) /Source="Nicolas_upshifts" /id="D1187" /incds=0 /nref=33 /ntot=254 /MaxReadThrough="6.68474" /MaxDrop="5.1938" /score="8.50521108" /energy="-10.5" /TU="U1780" /idTUdmin="U1781" /TUdmin=530 /isTUend="FALSE" /label="downshifts" CDS complement(2054959..2055237) /gene="hbs" /locus_tag="BSU_22790" /old_locus_tag="BSU22790" /function="16.1: Circulate" /function="16.3: Control" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:1382620, 9106208, 10224127, 10231583, 10715001, 11931565, 19210617" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1382620, 9106208, 10224127, 10231583, 10715001, 11931565, 19210617; Product type f: factor" /codon_start=1 /transl_table=11 /product="non-specific DNA-binding protein HBsu" /protein_id="NP_390160.1" /db_xref="EnsemblGenomes-Gn:BSU22790" /db_xref="EnsemblGenomes-Tr:CAB14195" /db_xref="GOA:P08821" /db_xref="InterPro:IPR000119" /db_xref="InterPro:IPR010992" /db_xref="InterPro:IPR020816" /db_xref="SubtiList:BG10276" /db_xref="UniProtKB/Swiss-Prot:P08821" /translation="MNKTELINAVAEASELSKKDATKAVDSVFDTILDALKNGDKIQL IGFGNFEVRERSARKGRNPQTGEEIEIPASKVPAFKPGKALKDAVAGK*" /label="hbs CDS" gene complement(2054959..2055237) /gene="hbs" /locus_tag="BSU_22790" /old_locus_tag="BSU22790" /label="hbs gene" S_feature complement(2055238..2055463) /Source="Nicolas_S_feature" /locus_tag="new_2385822_2386047_c" /HighExp="dia5, C90, T-0.40H, G/S, S1, Salt, Lbexp, dia15, T-1.40H, BI" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="SigEF" /TUlongPSig=1 /label="S861" promotor_-10 complement(2055445..2055464) /Source="Nicolas_upshift_promotors" /id="U1780" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.591408591408591" /psig="0.998001998001998" /xcortree=2643 /SigmaFactorBS="aaaaaaggaatattcgttcggtaaatcaccttaaatcCTTGA CgagcaagggattgacgCTTTAAAATGCTTGATATGGctttttatatgtgttactcta c" /listShort="S861, hbs, S860, folEA, mtrB, S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-10" upshifts complement(2055463) /Source="Nicolas_upshifts" /id="U1780" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.591408591408591" /psig="0.998001998001998" /xcortree=2643 /SigmaFactorBS="aaaaaaggaatattcgttcggtaaatcaccttaaatcCTTGA CgagcaagggattgacgCTTTAAAATGCTTGATATGGctttttatatgtgttactcta c" /listShort="S861, hbs, S860, folEA, mtrB, S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="upshifts" promotor_-35 complement(2055481..2055486) /Source="Nicolas_upshift_promotors" /id="U1780" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.591408591408591" /psig="0.998001998001998" /xcortree=2643 /SigmaFactorBS="aaaaaaggaatattcgttcggtaaatcaccttaaatcCTTGA CgagcaagggattgacgCTTTAAAATGCTTGATATGGctttttatatgtgttactcta c" /listShort="S861, hbs, S860, folEA, mtrB, S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-35" CDS complement(2055611..2057089) /gene="spoIVA" /locus_tag="BSU_22800" /old_locus_tag="BSU22800" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11160095, 17114257, 17427285, 24810258, 26387458, 28408070" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11160095, 17114257, 17427285, 24810258, 26387458, 28408070; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="morphogenetic stage IV sporulation protein" /protein_id="NP_390161.1" /db_xref="EnsemblGenomes-Gn:BSU22800" /db_xref="EnsemblGenomes-Tr:CAB14196" /db_xref="GOA:P35149" /db_xref="InterPro:IPR014201" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10275" /db_xref="UniProtKB/Swiss-Prot:P35149" /translation="MEKVDIFKDIAERTGGDIYLGVVGAVRTGKSTFIKKFMELVVLP NISNEADRARAQDELPQSAAGKTIMTTEPKFVPNQAMSVHVSDGLDVNIRLVDCVGYT VPGAKGYEDENGPRMINTPWYEEPIPFHEAAEIGTRKVIQEHSTIGVVITTDGTIGDI ARSDYIEAEERVIEELKEVGKPFIMVINSVRPYHPETEAMRQDLSEKYDIPVLAMSVE SMRESDVLSVLREALYEFPVLEVNVNLPSWVMVLKENHWLRESYQESVKETVKDIKRL RDVDRVVGQFSEFEFIESAGLAGIELGQGVAEIDLYAPDHLYDQILKEVVGVEIRGRD HLLELMQDFAHAKTEYDQVSDALKMVKQTGYGIAAPALADMSLDEPEIIRQGSRFGVR LKAVAPSIHMIKVDVESEFAPIIGTEKQSEELVRYLMQDFEDDPLSIWNSDIFGRSLS SIVREGIQAKLSLMPENARYKLKETLERIINEGSGGLIAIIL*" /label="spoIVA CDS" gene complement(2055611..2057089) /gene="spoIVA" /locus_tag="BSU_22800" /old_locus_tag="BSU22800" /label="spoIVA gene" downshifts complement(2055624) /Source="Nicolas_upshifts" /id="D1188" /incds=0 /nref=59 /ntot=76 /MaxReadThrough="3.43222" /MaxDrop="7.13908" /score="13.6316529" /energy="-9.2" /TU="U1781" /idTUdmin="U1782" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2057090..2057251) /Source="Nicolas_S_feature" /locus_tag="new_2387674_2387835_c" /HighExp="S3, S4, S5, S6, LoTm, S7, B36, BT, T5.0H, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S862" promotor_-10 complement(2057238..2057256) /Source="Nicolas_upshift_promotors" /id="U1781" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1096 /SigmaFactorBS="gtaaatgacaaacaggaacctgtttttttagaaaatgatatg aaaaaGGAATGaacctttctcccttGCATACAAATAGGGAGAAAggtttttttatatt a" /listShort="S862, spoIVA" /listLong="S861, hbs, S860, folEA, mtrB, S859, hepS, menH, hepT, ndk, S858" /label="promotor_-10" upshifts complement(2057263) /Source="Nicolas_upshifts" /id="U1781" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1096 /SigmaFactorBS="gtaaatgacaaacaggaacctgtttttttagaaaatgatatg aaaaaGGAATGaacctttctcccttGCATACAAATAGGGAGAAAggtttttttatatt a" /listShort="S862, spoIVA" /listLong="S861, hbs, S860, folEA, mtrB, S859, hepS, menH, hepT, ndk, S858" /label="upshifts" CDS complement(2057270..2058004) /gene="yphF" /locus_tag="BSU_22810" /old_locus_tag="BSU22810" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein of unknown function" /protein_id="NP_390162.1" /db_xref="EnsemblGenomes-Gn:BSU22810" /db_xref="EnsemblGenomes-Tr:CAB14197" /db_xref="SubtiList:BG10274" /db_xref="UniProtKB/Swiss-Prot:P39911" /translation="MGKLKCAIIFAAVVFLSGCLYPNERKSSVHAIPYQDQLKQVQSA VDEFQKANGGLLPIQTKDMSTPLYQKYPIDFNRLAPRYIAEPPSTAFESGGDYQYVLV DVENDPTVKLIDLKMAEKIRDVKLRIQMYRQEHQYPPYKDVLSRDLFTLDEKKLGDGS SLTVTSPISGNSLPLMIDGDGEIYADYRTELASCLKKSKKTFKPGTEIQDMIWHETPF VPAFSVKYTVNDKQEPVFLENDMKKE*" /label="yphF CDS" gene complement(2057270..2058004) /gene="yphF" /locus_tag="BSU_22810" /old_locus_tag="BSU22810" /label="yphF gene" promotor_-35 complement(2057271..2057276) /Source="Nicolas_upshift_promotors" /id="U1781" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1096 /SigmaFactorBS="gtaaatgacaaacaggaacctgtttttttagaaaatgatatg aaaaaGGAATGaacctttctcccttGCATACAAATAGGGAGAAAggtttttttatatt a" /listShort="S862, spoIVA" /listLong="S861, hbs, S860, folEA, mtrB, S859, hepS, menH, hepT, ndk, S858" /label="promotor_-35" downshifts complement(2057296) /Source="Nicolas_upshifts" /id="D1189" /incds=0 /nref=6 /ntot=78 /MaxReadThrough="6.50932" /MaxDrop="4.759" /score="15.8109079" /energy="-12.7" /TU="U1782" /idTUdmin="U1783" /TUdmin=1100 /isTUend="FALSE" /label="downshifts" CDS complement(2058026..2058229) /gene="yphE" /locus_tag="BSU_22820" /old_locus_tag="BSU22820" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390163.1" /db_xref="EnsemblGenomes-Gn:BSU22820" /db_xref="EnsemblGenomes-Tr:CAB14198" /db_xref="GOA:P50744" /db_xref="InterPro:IPR020076" /db_xref="SubtiList:BG11444" /db_xref="UniProtKB/Swiss-Prot:P50744" /translation="MNLALMKMWFALGSMGLMFLAVASIYLSRFKCQNRFLKIAISSF AYMCMLISGIIVFVVVFSGPVNE*" /label="yphE CDS" gene complement(2058026..2058229) /gene="yphE" /locus_tag="BSU_22820" /old_locus_tag="BSU22820" /label="yphE gene" promotor_-10 complement(2058265..2058284) /Source="Nicolas_upshift_promotors" /id="U1782" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.491508491508492" /psig=1 /xcortree=3051 /SigmaFactorBS="tttgcttcagtttttttgttctatcaatggatggaaaatctG GTTGATCttttccggcgctgTATATTAAAATATAATATAAcgcttatatcttacatat c" /listShort="yphE, yphF, S862, spoIVA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2058286) /Source="Nicolas_upshifts" /id="U1782" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.491508491508492" /psig=1 /xcortree=3051 /SigmaFactorBS="tttgcttcagtttttttgttctatcaatggatggaaaatctG GTTGATCttttccggcgctgTATATTAAAATATAATATAAcgcttatatcttacatat c" /listShort="yphE, yphF, S862, spoIVA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2058298..2058305) /Source="Nicolas_upshift_promotors" /id="U1782" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.491508491508492" /psig=1 /xcortree=3051 /SigmaFactorBS="tttgcttcagtttttttgttctatcaatggatggaaaatctG GTTGATCttttccggcgctgTATATTAAAATATAATATAAcgcttatatcttacatat c" /listShort="yphE, yphF, S862, spoIVA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2058351..2058550) /Source="Nicolas_S_feature" /locus_tag="new_2388935_2389134_c" /HighExp="S7, S8, S6, C30, BT, G135, G180, Oxctl, Cold, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA, Sig-" /TUshortPSig="1, 1, 0.481" /TUlongSig="NA" /TUlongPSig="NA" /label="S863" downshifts complement(2058394) /Source="Nicolas_upshifts" /id="D1190" /incds=0 /nref=264 /ntot=295 /MaxReadThrough="2.22999" /MaxDrop="8.05743" /score="26.216597" /energy="-14.1" /TU="NA" /idTUdmin="U1783" /TUdmin=2 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2058525..2058544) /Source="Nicolas_upshift_promotors" /id="U1783" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1314 /SigmaFactorBS="agatggaggatttggtaaatacgtttgaaaatcaagtgaagt aAAAGTGTCAAtcaaatggtgaatCGCATATCTTAATTGAACGAaagcccgaaaaaca g" /listShort="S863" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2058550) /Source="Nicolas_upshifts" /id="U1783" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1314 /SigmaFactorBS="agatggaggatttggtaaatacgtttgaaaatcaagtgaagt aAAAGTGTCAAtcaaatggtgaatCGCATATCTTAATTGAACGAaagcccgaaaaaca g" /listShort="S863" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2058558..2058567) /Source="Nicolas_upshift_promotors" /id="U1783" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1314 /SigmaFactorBS="agatggaggatttggtaaatacgtttgaaaatcaagtgaagt aAAAGTGTCAAtcaaatggtgaatCGCATATCTTAATTGAACGAaagcccgaaaaaca g" /listShort="S863" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2058567..2059604) /gene="gpsA" /locus_tag="BSU_22830" /old_locus_tag="BSU22830" /EC_number="1.1.1.94" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7592341, 12682299, 15557260" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7592341, 12682299, 15557260; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADPH-dependent glycerol-3-phosphate dehydrogenase" /protein_id="NP_390164.1" /db_xref="EnsemblGenomes-Gn:BSU22830" /db_xref="EnsemblGenomes-Tr:CAB14199" /db_xref="GOA:P46919" /db_xref="InterPro:IPR006109" /db_xref="InterPro:IPR006168" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR011128" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11366" /db_xref="UniProtKB/Swiss-Prot:P46919" /translation="MKKVTMLGAGSWGTALALVLTDNGNEVCVWAHRADLIHQINELH ENKDYLPNVKLSTSIKGTTDMKEAVSDADVIIVAVPTKAIREVLRQAVPFITKKAVFV HVSKGIEPDSLLRISEIMEIELPSDVRKDIVVLSGPSHAEEVGLRHPTTVTASSKSMR AAEEVQDLFINHNFRVYTNPDIIGVEIGGALKNIIALAAGITDGLGYGDNAKAALITR GLAEIARLGTKMGGNPLTFSGLTGVGDLIVTCTSVHSRNWRAGNLLGKGYKLEDVLEE MGMVVEGVRTTKAAYQLSKKYDVKMPITEALHQVLFNGQKVETAVESLMARGKTHEME DLVNTFENQVK*" /label="gpsA CDS" gene complement(2058567..2059604) /gene="gpsA" /locus_tag="BSU_22830" /old_locus_tag="BSU22830" /label="gpsA gene" CDS complement(2059622..2060932) /gene="der" /locus_tag="BSU_22840" /old_locus_tag="BSU22840" /EC_number="3.6.5.-" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 16682769, 16894162, 16997968, 19246542, 23056455, 24822275, 27484475" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16682769, 16894162, 16997968, 19246542, 23056455, 24822275, 27484475; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GTPase essential for ribosome 50S subunit assembly (maturation of the 50S subunit central protoberance)" /protein_id="NP_390165.1" /db_xref="EnsemblGenomes-Gn:BSU22840" /db_xref="EnsemblGenomes-Tr:CAB14200" /db_xref="GOA:P50743" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR016484" /db_xref="InterPro:IPR027368" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031166" /db_xref="InterPro:IPR032859" /db_xref="PDB:2HJG" /db_xref="PDB:4DCS" /db_xref="PDB:4DCT" /db_xref="PDB:4DCU" /db_xref="PDB:4DCV" /db_xref="PDB:4KYU" /db_xref="PDB:5X4B" /db_xref="SubtiList:BG11443" /db_xref="UniProtKB/Swiss-Prot:P50743" /translation="MGKPVVAIVGRPNVGKSTIFNRIAGERISIVEDTPGVTRDRIYS SAEWLNYDFNLIDTGGIDIGDEPFLAQIRQQAEIAMDEADVIIFMVNGREGVTAADEE VAKILYRTKKPVVLAVNKLDNTEMRANIYDFYSLGFGEPYPISGTHGLGLGDLLDAVA EHFKNIPETKYNEEVIQFCLIGRPNVGKSSLVNAMLGEERVIVSNVAGTTRDAVDTSF TYNQQEFVIVDTAGMRKKGKVYETTEKYSVLRALKAIDRSEVVAVVLDGEEGIIEQDK RIAGYAHEAGKAVVIVVNKWDAVDKDESTMKEFEENIRDHFQFLDYAPILFMSALTKK RIHTLMPAIIKASENHSLRVQTNVLNDVIMDAVAMNPTPTHNGSRLKIYYATQVSVKP PSFVVFVNDPELMHFSYERFLENRIRDAFGFEGTPIKIFARARK*" /label="der CDS" gene complement(2059622..2060932) /gene="der" /locus_tag="BSU_22840" /old_locus_tag="BSU22840" /label="der gene" S_feature complement(2060933..2061057) /Source="Nicolas_S_feature" /locus_tag="new_2391517_2391641_c" /HighExp="Cold, G180, G150, Oxctl, G135, C30, LBGexp, Paraq, dia0, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0.481" /TUlongSig="NA" /TUlongPSig="NA" /label="S864" promotor_-10 complement(2061043..2061062) /Source="Nicolas_upshift_promotors" /id="U1784" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=2499 /SigmaFactorBS="atgacgtgtatttgatcgtgaaacatttttaagaataGTTGt gatcccagtaaaaACTGATATAATAAATGAGTTaagcccttcctctgaagggtttctt t" /listShort="S864, engA, gpsA, S863" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2061057) /Source="Nicolas_upshifts" /id="U1784" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=2499 /SigmaFactorBS="atgacgtgtatttgatcgtgaaacatttttaagaataGTTGt gatcccagtaaaaACTGATATAATAAATGAGTTaagcccttcctctgaagggtttctt t" /listShort="S864, engA, gpsA, S863" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2061077..2061080) /Source="Nicolas_upshift_promotors" /id="U1784" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=2499 /SigmaFactorBS="atgacgtgtatttgatcgtgaaacatttttaagaataGTTGt gatcccagtaaaaACTGATATAATAAATGAGTTaagcccttcctctgaagggtttctt t" /listShort="S864, engA, gpsA, S863" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2061086..2061280) /gene="ypzH" /locus_tag="BSU_22849" /old_locus_tag="BSU22849" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097755.1" /db_xref="EnsemblGenomes-Gn:BSU22849" /db_xref="EnsemblGenomes-Tr:CAX52654" /db_xref="UniProtKB/Swiss-Prot:C0H445" /translation="MSESLTKVILSVITTNRNRVAGGAPVFFCNDQKEMELFAKNLEA ILDGIAHRIGDDVYLIVKHF*" /label="ypzH CDS" gene complement(2061086..2061280) /gene="ypzH" /locus_tag="BSU_22849" /old_locus_tag="BSU22849" /label="ypzH gene" CDS complement(2061277..2062170) /gene="yphB" /locus_tag="BSU_22850" /old_locus_tag="BSU22850" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_390166.1" /db_xref="EnsemblGenomes-Gn:BSU22850" /db_xref="EnsemblGenomes-Tr:CAB14201" /db_xref="GOA:P50742" /db_xref="InterPro:IPR025918" /db_xref="SubtiList:BG11442" /db_xref="UniProtKB/Swiss-Prot:P50742" /translation="MSDYIYPIIAGVIAGIATRLYMLKTDYRQYPTYVHGKVIHIALG LIAAGLGAIIMPALLQEEFTAITFLTLAATQFRDVRNMERNTLTQMDSYELVSRGSTY IEGIAIAFESRNYIVIFTALLTTSAYVFLSIWAAVIAAVVCFLLAMKFMSGSVLKDIV DIEYIKPRFDGPGLFVDNIYMMNIGLPEKQELILKHGMGFILTPKNFNSAATIANLGQ RQAILFDVSNVLGVYRDSGEPSLTPIAKRDLNDGRVAVFVLPQIHHPETAVQIISNVP TLENAIRMPTEFIKNQDKVIG*" /label="yphB CDS" gene complement(2061277..2062170) /gene="yphB" /locus_tag="BSU_22850" /old_locus_tag="BSU22850" /label="yphB gene" CDS complement(2062167..2062766) /gene="yphA" /locus_tag="BSU_22860" /old_locus_tag="BSU22860" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406; Product type m:membrane component" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_390167.1" /db_xref="EnsemblGenomes-Gn:BSU22860" /db_xref="EnsemblGenomes-Tr:CAB14202" /db_xref="GOA:P50741" /db_xref="InterPro:IPR014617" /db_xref="SubtiList:BG11441" /db_xref="UniProtKB/Swiss-Prot:P50741" /translation="MEQFYYYWSMWFLWVLTTFIFEKTKRRIAVSVFILTNIILSIHD IALYFSLNAAYLMFFVCGCVYAGYLGMYRFRYIMVYLTLVAAYAFVYLFALYDPVWFI IKPEWAAVILIVLLTASVERNFEKQLVLFVLGMCQGELVYSFVIQKLAGAMAVGGFQW LNACSAGMILLFGISKYEHLASQIGQKSKRSNKGATKMS*" /label="yphA CDS" gene complement(2062167..2062766) /gene="yphA" /locus_tag="BSU_22860" /old_locus_tag="BSU22860" /label="yphA gene" promotor_-35 2062639..2062645 /Source="Nicolas_upshift_promotors" /id="U1785" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.6003996003996" /psig="0.6003996003996" /xcortree=787 /SigmaFactorBS="catcaaatatgcagcattcagggaaaaatataaagcgatgtc aTGTATGCttagaataatattAGTTAAAATAAAgacagagacggcaattcgtcttttc g" /listShort="S865, ypzI" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2062654..2062837 /Source="Nicolas_S_feature" /locus_tag="new_2393238_2393421" /HighExp="S5, S8, S6, S7, BT, S4, ferm, nit, Pyr, G/S" /AntisenseName="yphA" /AntisenseCor="0.73324773408178501" /AntisenseRegPval="-45.9" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.6" /TUlongSig="NA" /TUlongPSig="NA" /label="S865" upshifts 2062656 /Source="Nicolas_upshifts" /id="U1785" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.6003996003996" /psig="0.6003996003996" /xcortree=787 /SigmaFactorBS="catcaaatatgcagcattcagggaaaaatataaagcgatgtc aTGTATGCttagaataatattAGTTAAAATAAAgacagagacggcaattcgtcttttc g" /listShort="S865, ypzI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2062659..2062670 /Source="Nicolas_upshift_promotors" /id="U1785" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.6003996003996" /psig="0.6003996003996" /xcortree=787 /SigmaFactorBS="catcaaatatgcagcattcagggaaaaatataaagcgatgtc aTGTATGCttagaataatattAGTTAAAATAAAgacagagacggcaattcgtcttttc g" /listShort="S865, ypzI" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2062777..2062795) /Source="Nicolas_upshift_promotors" /id="U1786" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.48051948051948" /psig="0.48051948051948" /xcortree=969 /SigmaFactorBS="tgtcttttcccatgatcatactccttaatgtgagatcgatTG TTTAaaaaatgtgcttgaaCTCCATACTGGGAATATGGaggaagtaaaatggaacaat t" /listShort="yphA, seaA, ypzH, S864, engA, gpsA, S863" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2062796) /Source="Nicolas_upshifts" /id="U1786" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.48051948051948" /psig="0.48051948051948" /xcortree=969 /SigmaFactorBS="tgtcttttcccatgatcatactccttaatgtgagatcgatTG TTTAaaaaatgtgcttgaaCTCCATACTGGGAATATGGaggaagtaaaatggaacaat t" /listShort="yphA, seaA, ypzH, S864, engA, gpsA, S863" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2062811..2062816) /Source="Nicolas_upshift_promotors" /id="U1786" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.48051948051948" /psig="0.48051948051948" /xcortree=969 /SigmaFactorBS="tgtcttttcccatgatcatactccttaatgtgagatcgatTG TTTAaaaaatgtgcttgaaCTCCATACTGGGAATATGGaggaagtaaaatggaacaat t" /listShort="yphA, seaA, ypzH, S864, engA, gpsA, S863" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2062844..2062975 /gene="ypzI" /locus_tag="BSU_22869" /old_locus_tag="BSU22869" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences" /codon_start=1 /transl_table=11 /product="putative sporulation-related protein" /protein_id="YP_003097756.2" /db_xref="EnsemblGenomes-Gn:BSU22869" /db_xref="EnsemblGenomes-Tr:CAX52655" /db_xref="InterPro:IPR025414" /db_xref="UniProtKB/Swiss-Prot:C0H446" /translation="MGKDRQEKKLKASGRVESDRDQSIHYDGATSLEQNGRFKKRKS* " /label="ypzI CDS" gene 2062844..2062975 /gene="ypzI" /locus_tag="BSU_22869" /old_locus_tag="BSU22869" /label="ypzI gene" downshifts 2062963 /Source="Nicolas_upshifts" /id="D1191" /incds=0 /nref=37 /ntot=122 /MaxReadThrough="0.20384" /MaxDrop="6.94664" /score="3.33160455" /energy="-13.2" /TU="NA" /idTUdmin="U1785" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(2063018..2064067) /gene="fni" /locus_tag="BSU_22870" /old_locus_tag="BSU22870" /EC_number="5.3.3.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12798687, 14745175, 15206931" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12798687, 14745175, 15206931; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isopentenyl diphosphate isomerase (typeII)" /protein_id="NP_390168.3" /db_xref="EnsemblGenomes-Gn:BSU22870" /db_xref="EnsemblGenomes-Tr:CAB14203" /db_xref="GOA:P50740" /db_xref="InterPro:IPR000262" /db_xref="InterPro:IPR011179" /db_xref="InterPro:IPR013785" /db_xref="PDB:1P0K" /db_xref="PDB:1P0N" /db_xref="SubtiList:BG11440" /db_xref="UniProtKB/Swiss-Prot:P50740" /translation="MTRAERKRQHINHALSIGQKRETGLDDITFVHVSLPDLALEQVD ISTKIGELSSSSPIFINAMTGGGGKLTYEINKSLARAASQAGIPLAVGSQMSALKDPS ERLSYEIVRKENPNGLIFANLGSEATAAQAKEAVEMIGANALQIHLNVIQEIVMPEGD RSFSGALKRIEQICSRVSVPVIVKEVGFGMSKASAGKLYEAGAAAVDIGGYGGTNFSK IENLRRQRQISFFNSWGISTAASLAEIRSEFPASTMIASGGLQDALDVAKAIALGASC TGMAGHFLKALTDSGEEGLLEEIQLILEELKLIMTVLGARTIADLQKAPLVIKGETHH WLTERGVNTSSYSVR*" /label="fni CDS" gene complement(2063018..2064067) /gene="fni" /locus_tag="BSU_22870" /old_locus_tag="BSU22870" /label="fni gene" downshifts complement(2063038) /Source="Nicolas_upshifts" /id="D1192" /incds=0 /nref=209 /ntot=250 /MaxReadThrough="1.39069" /MaxDrop="4.82362" /score="15.2467448" /energy="-13.2" /TU="NA" /idTUdmin="U1788" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2063942) /Source="Nicolas_upshifts" /id="D1193" /incds=1 /nref=45 /ntot=237 /MaxReadThrough="6.15611" /MaxDrop="4.91722" /score="13.2731686" /energy="-15.7" /TU="U1788,U1789,U1790" /idTUdmin="U1788" /TUdmin="-904" /isTUend="FALSE" /label="downshifts" CDS complement(2064080..2065228) /gene="rpfA" /locus_tag="BSU_22880" /old_locus_tag="BSU22880" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9179491, 9862121, 14586115; Product type f: factor" /codon_start=1 /transl_table=11 /product="RNA degradation presenting factor (ribosomal protein S1 homolog)" /protein_id="NP_390169.1" /db_xref="EnsemblGenomes-Gn:BSU22880" /db_xref="EnsemblGenomes-Tr:CAB14204" /db_xref="GOA:P38494" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR022967" /db_xref="SubtiList:BG11005" /db_xref="UniProtKB/Swiss-Prot:P38494" /translation="MTEEMNQIDVQVPEVGDVVKGIVTKVEDKHVDVEIINVKQSGII PISELSSLHVEKASDVVKVDDELDLKVTKVEDDALILSKRAVDADRAWEDLEKKFETK EVFEAEVKDVVKGGLVVDIGVRGFIPASLVEAHFVEDFTDYKGKTLSLLVVELDRDKN RVILSHRAVVESEQANKKQELLQSLEVGSVLDGKVQRLTDFGAFVDIGGIDGLVHISQ LSHSHVEKPSDVVEEGQEVKVKVLSVDRDNERISLSIKDTLPGPWNQIGEKVKPGDVL EGTVQRLVSFGAFVEILPGVEGLVHISQISNKHIGTPHEVLEEGQTVKVKVLDVNENE ERISLSMRELEETPKADQEDYRQYQAKEETSTGFQLGDLIGDKLNKLK*" /label="rpfA CDS" gene complement(2064080..2065228) /gene="rpfA" /locus_tag="BSU_22880" /old_locus_tag="BSU22880" /label="rpfA gene" misc_feature 2064409..2064412 /Source="Nicolas_upshift_promotors" /id="U1787" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.677322677322677" /psig="0.023976023976024" /xcortree=89 /SigmaFactorBS="ttacaagacgctgtacagttccttcaagcacatCGCCaggct tcactttttcgccgatttggttccaaggtccaggcagtgtatctttgatcgataaaga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2064436 /Source="Nicolas_upshifts" /id="U1787" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.677322677322677" /psig="0.023976023976024" /xcortree=89 /SigmaFactorBS="ttacaagacgctgtacagttccttcaagcacatCGCCaggct tcactttttcgccgatttggttccaaggtccaggcagtgtatctttgatcgataaaga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2064502 /Source="Nicolas_upshifts" /id="D1194" /incds=1 /nref=1 /ntot=124 /MaxReadThrough="1.88188" /MaxDrop="2.8624" /score="-3.97389972" /energy="-11.8" /TU="NA" /idTUdmin="U1787" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 2065206 /Source="Nicolas_upshifts" /id="D1195" /incds=0 /nref=3 /ntot=200 /MaxReadThrough="1.33117" /MaxDrop="3.08345" /score="-3.97389972" /energy="-11.8" /TU="NA" /idTUdmin="U1787" /TUdmin=704 /isTUend="FALSE" /label="downshifts" S_feature complement(2065229..2065368) /Source="Nicolas_S_feature" /locus_tag="new_2395813_2395952_c" /HighExp="C90, Salt, Etha, Lbtran, HiOs, M40t90, S1, LBGtran, LoTm, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF, SigA" /TUshortPSig="0.999, 0.703, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S866" promotor_-10 complement(2065367..2065386) /Source="Nicolas_upshift_promotors" /id="U1788" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.802197802197802" /psig="0.999000999001" /xcortree=2236 /SigmaFactorBS="aacgaagatagaatgttattGCTTGACAaacctgtcctttta TTAGAAGTTAATACTAATAAaactttttattgatcattcaaaaaacttttttggatga t" /listShort="S866, ypfD, fni" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2065368) /Source="Nicolas_upshifts" /id="U1788" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.802197802197802" /psig="0.999000999001" /xcortree=2236 /SigmaFactorBS="aacgaagatagaatgttattGCTTGACAaacctgtcctttta TTAGAAGTTAATACTAATAAaactttttattgatcattcaaaaaacttttttggatga t" /listShort="S866, ypfD, fni" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2065370..2065460) /Source="Nicolas_S_feature" /locus_tag="new_2395954_2396044_c" /HighExp="G135, G180, LBGexp, C30, Cold, Oxctl, dia0, G150, Paraq, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.40511799999999998" /TUshortSig="SigEF, SigA" /TUshortPSig="0.703, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S867" promotor_-35 complement(2065401..2065408) /Source="Nicolas_upshift_promotors" /id="U1788" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.802197802197802" /psig="0.999000999001" /xcortree=2236 /SigmaFactorBS="aacgaagatagaatgttattGCTTGACAaacctgtcctttta TTAGAAGTTAATACTAATAAaactttttattgatcattcaaaaaacttttttggatga t" /listShort="S866, ypfD, fni" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2065461..2066135) /gene="cmk" /locus_tag="BSU_22890" /old_locus_tag="BSU22890" /EC_number="2.7.4.25" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8576266, 9179491, 9862121, 11827479, 12682299, 16880539" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8576266, 9179491, 9862121, 11827479, 12682299, 16880539; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cytidylate kinase" /protein_id="NP_390170.1" /db_xref="EnsemblGenomes-Gn:BSU22890" /db_xref="EnsemblGenomes-Tr:CAB14205" /db_xref="GOA:P38493" /db_xref="InterPro:IPR003136" /db_xref="InterPro:IPR011994" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11004" /db_xref="UniProtKB/Swiss-Prot:P38493" /translation="MEKKLSIAIDGPAAAGKSTVAKIVAEKKSYIYIDTGAMYRAITY AALQENVDLTDEEKLAELLKRTDIELITTKDGQKVFVNGTDVTEAIRTDEISNQVSIA AKHRSVREEMVKRQQQLGEKGGVVMDGRDIGTHVLPNAEVKIFLLASVEERAKRRYEE NVKKGFDVNYETLIEEIARRDKLDSEREVSPLRKAEDALEIDTTSLSIQEVADKILEA VEQKSR*" /label="cmk CDS" gene complement(2065461..2066135) /gene="cmk" /locus_tag="BSU_22890" /old_locus_tag="BSU22890" /label="cmk gene" S_feature complement(2066136..2066213) /Source="Nicolas_S_feature" /locus_tag="new_2396720_2396797_c" /HighExp="S4, S5, S7, S8, S6, dia15, S3, Diami, dia5, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.703, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S868" CDS complement(2066214..2066390) /gene="ypfB" /locus_tag="BSU_22900" /old_locus_tag="BSU22900" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_390171.1" /db_xref="EnsemblGenomes-Gn:BSU22900" /db_xref="EnsemblGenomes-Tr:CAB14206" /db_xref="InterPro:IPR035281" /db_xref="SubtiList:BG11003" /db_xref="UniProtKB/Swiss-Prot:P38492" /translation="MKTFERLLIKLLFIQAIILLGVQFLFHYQHIEPYVSKVIQYEGV DKMEENNRIETFKH*" /label="ypfB CDS" gene complement(2066214..2066390) /gene="ypfB" /locus_tag="BSU_22900" /old_locus_tag="BSU22900" /label="ypfB gene" promotor_-10 complement(2066402..2066420) /Source="Nicolas_upshift_promotors" /id="U1789" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.703296703296703" /psig="0.703296703296703" /xcortree=1196 /SigmaFactorBS="atcaggcgccagttaaataagagaagaaaggcccgaatGGAA TAAacatcggcaaacacTTCCATACTATTTGTAATGgaggtgctccaatgaaaacatt t" /listShort="ypfB, S868, cmk, S867, S866, ypfD, fni" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2066419) /Source="Nicolas_upshifts" /id="U1789" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.703296703296703" /psig="0.703296703296703" /xcortree=1196 /SigmaFactorBS="atcaggcgccagttaaataagagaagaaaggcccgaatGGAA TAAacatcggcaaacacTTCCATACTATTTGTAATGgaggtgctccaatgaaaacatt t" /listShort="ypfB, S868, cmk, S867, S866, ypfD, fni" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2066435..2066441) /Source="Nicolas_upshift_promotors" /id="U1789" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.703296703296703" /psig="0.703296703296703" /xcortree=1196 /SigmaFactorBS="atcaggcgccagttaaataagagaagaaaggcccgaatGGAA TAAacatcggcaaacacTTCCATACTATTTGTAATGgaggtgctccaatgaaaacatt t" /listShort="ypfB, S868, cmk, S867, S866, ypfD, fni" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2066435..2067088) /gene="dgrA" /locus_tag="BSU_22910" /old_locus_tag="BSU22910" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16249258, 23893111, 28536559" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16249258, 23893111, 28536559; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="cyclic di-GMP receptor" /protein_id="NP_390172.1" /db_xref="EnsemblGenomes-Gn:BSU22910" /db_xref="EnsemblGenomes-Tr:CAB14207" /db_xref="GOA:P38491" /db_xref="InterPro:IPR009875" /db_xref="InterPro:IPR009926" /db_xref="InterPro:IPR012349" /db_xref="SubtiList:BG11002" /db_xref="UniProtKB/Swiss-Prot:P38491" /translation="MIEIGENVLLEYIEENELKKAKSKAVSIENNELLIAYPVDVVTG RTVILHNDMEVTVEFVGKDEVPYRFISRIKGKVKDKLQMICLEMPPREKMKRIQRRQY VRTDAVLDVQIQPGNEEEIRTLSYNISAGGIAVVLADGLSFQSGESLRLIIRLPEEEH TRQIETEAVVRRIFNDPKSEKRKMTLEYSEIAAGDQQALLQYCIRRQLNKRRKARME* " /label="dgrA CDS" gene complement(2066435..2067088) /gene="dgrA" /locus_tag="BSU_22910" /old_locus_tag="BSU22910" /label="dgrA gene" promotor_-10 complement(2067118..2067137) /Source="Nicolas_upshift_promotors" /id="U1790" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2544 /SigmaFactorBS="aagacctataaaaacaggaggaaaggactaaatgTCTTTtcc tttttttcattaCGTGCTTTAATAAAAACGTGagtatattgaatgcgaaagagtgaag t" /listShort="ypfA, ypfB, S868, cmk, S867, S866, ypfD, fni" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2067131) /Source="Nicolas_upshifts" /id="U1790" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2544 /SigmaFactorBS="aagacctataaaaacaggaggaaaggactaaatgTCTTTtcc tttttttcattaCGTGCTTTAATAAAAACGTGagtatattgaatgcgaaagagtgaag t" /listShort="ypfA, ypfB, S868, cmk, S867, S866, ypfD, fni" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2067153..2067157) /Source="Nicolas_upshift_promotors" /id="U1790" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2544 /SigmaFactorBS="aagacctataaaaacaggaggaaaggactaaatgTCTTTtcc tttttttcattaCGTGCTTTAATAAAAACGTGagtatattgaatgcgaaagagtgaag t" /listShort="ypfA, ypfB, S868, cmk, S867, S866, ypfD, fni" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2067181..2068533) /gene="sleC" /locus_tag="BSU_22920" /old_locus_tag="BSU22920" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10658652, 12177332, 22720735, 23543708, 24752279, 25022853, 25384476, 26187959" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10658652, 12177332, 22720735, 23543708, 24752279, 25022853, 25384476, 26187959; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination membrane component" /protein_id="NP_390173.1" /db_xref="EnsemblGenomes-Gn:BSU22920" /db_xref="EnsemblGenomes-Tr:CAB14208" /db_xref="GOA:P38490" /db_xref="InterPro:IPR014239" /db_xref="InterPro:IPR025711" /db_xref="SubtiList:BG11001" /db_xref="UniProtKB/Swiss-Prot:P38490" /translation="MIRGILIAVLGIAIVGTGYWGYKEHQEKDAVLLHAENNYQRAFH ELTYQVDQLHDKIGTTLAMNSQKSLSPALIDVWRITSEAHNSVSQLPLTLMPFNKTEE LLSKIGDFSYKTSVRDLDQKPLDKNEYTSLNKLYQQSEDIQNELRHVQHLVMSKNLRW MDVEMALASDEKQSDNTIINSFKTVEKNVGAFSTGTDLGPSFTSTKKEEKGFSHLKGK QISEQEAKQIAERFAPDDNYSIKVVKSGKKTNRDVYSISMKDPDHKAVIYMDITKKGG HPVYLIQNREVKDQKISLNDGSNRALAFLKKNGFETDDLEIDESAQYDKIGVFSYVPV ENKVRMYPEAIRMKVALDDGEVVGFSARDFLTSHRKRTIPKPAITEAEAKSKLNKNVQ VRETRLALITNELGQEVLCYEMLGTIENDTFRMYINAKDGSEEKVEKLKNAEPIYKDL *" /label="sleC CDS" gene complement(2067181..2068533) /gene="sleC" /locus_tag="BSU_22920" /old_locus_tag="BSU22920" /label="sleC gene" downshifts complement(2067196) /Source="Nicolas_upshifts" /id="D1196" /incds=0 /nref=21 /ntot=44 /MaxReadThrough="0.647060000000002" /MaxDrop="5.74199" /score="16.6521528" /energy="-10.1" /TU="NA" /idTUdmin="U1791" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2068568..2069485) /gene="sleB" /locus_tag="BSU_22930" /old_locus_tag="BSU22930" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10658652, 12177332, 16905870, 16907803, 25963559, 26187959, 28333204" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10658652, 12177332, 16905870, 16907803, 25963559, 26187959, 28333204; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination cortex-lytic enzyme" /protein_id="NP_390174.1" /db_xref="EnsemblGenomes-Gn:BSU22930" /db_xref="EnsemblGenomes-Tr:CAB14209" /db_xref="GOA:P50739" /db_xref="InterPro:IPR002477" /db_xref="InterPro:IPR011105" /db_xref="InterPro:IPR014224" /db_xref="InterPro:IPR036365" /db_xref="InterPro:IPR036366" /db_xref="SubtiList:BG11439" /db_xref="UniProtKB/Swiss-Prot:P50739" /translation="MKSKGSIMACLILFSFTITTFINTETISAFSNQVIQRGATGDDV VELQARLQYNGYYNGKIDGVYGWGTYWAVRNFQDQFGLKEVDGLVGAKTKQTLICKSK YYREYVMEQLNKGNTFTHYGKIPLKYQTKPSKAATQKARQQAEARQKQPAEKTTQKPK ANANKQQNNTPAKARKQDAVAANMPGGFSNNDIRLLAQAVYGEARGEPYEGQVAIAAV ILNRLNSPLFPNSVAGVIFEPLAFTAVADGQIYMQPNETAREAVLDAINGWDPSEEAL YYFNPDTATSPWIWGRPQIKRIGKHIFCE*" /label="sleB CDS" gene complement(2068568..2069485) /gene="sleB" /locus_tag="BSU_22930" /old_locus_tag="BSU22930" /label="sleB gene" downshifts complement(2068956) /Source="Nicolas_upshifts" /id="D1197" /incds=1 /nref=1 /ntot=3 /MaxReadThrough="6.35344" /MaxDrop="4.29326" /score="-3.16364421" /energy="-21.7" /TU="U1791,U1792" /idTUdmin="U1793" /TUdmin=682 /isTUend="FALSE" /label="downshifts" misc_feature complement(2069107..2069114) /Source="Nicolas_upshift_promotors" /id="U1791" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.245754245754246" /psig="0.374625374625375" /xcortree=1472 /SigmaFactorBS="gaatatgtcatggaacagctcaataaagggaatacattcacg cattacggaaaaatTCCGCTAAagtatcagacgaaaccatcaaaagcagcaacacaaa a" /listShort="ypeB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2069110) /Source="Nicolas_upshifts" /id="U1791" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.245754245754246" /psig="0.374625374625375" /xcortree=1472 /SigmaFactorBS="gaatatgtcatggaacagctcaataaagggaatacattcacg cattacggaaaaatTCCGCTAAagtatcagacgaaaccatcaaaagcagcaacacaaa a" /listShort="ypeB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2069523..2069534) /Source="Nicolas_upshift_promotors" /id="U1792" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=937 /SigmaFactorBS="gtgcagtttttatgttctgagggataacaaggaaagagTGTA TAAaaataacctcgttACAGAAAATACGattacacttaaaaatttgcagtaggaggct t" /listShort="sleB, ypeB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2069532) /Source="Nicolas_upshifts" /id="U1792" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=937 /SigmaFactorBS="gtgcagtttttatgttctgagggataacaaggaaagagTGTA TAAaaataacctcgttACAGAAAATACGattacacttaaaaatttgcagtaggaggct t" /listShort="sleB, ypeB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2069548..2069554) /Source="Nicolas_upshift_promotors" /id="U1792" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=937 /SigmaFactorBS="gtgcagtttttatgttctgagggataacaaggaaagagTGTA TAAaaataacctcgttACAGAAAATACGattacacttaaaaatttgcagtaggaggct t" /listShort="sleB, ypeB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2069624..2070280) /gene="prsW" /locus_tag="BSU_22940" /old_locus_tag="BSU22940" /EC_number="3.4.-.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15849754, 16816000, 16850406, 17020587, 19889088, 23155385, 28674070" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16816000, 16850406, 17020587, 19889088, 23155385, 28674070; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protease required for RsiW anti-sigma(W) degradation" /protein_id="NP_390175.1" /db_xref="EnsemblGenomes-Gn:BSU22940" /db_xref="EnsemblGenomes-Tr:CAB14210" /db_xref="GOA:P50738" /db_xref="InterPro:IPR023596" /db_xref="InterPro:IPR026898" /db_xref="SubtiList:BG11438" /db_xref="UniProtKB/Swiss-Prot:P50738" /translation="MFAIISAGIAPGIALLSYFYLKDQYDNEPVHMVLRSFFLGVVLV FPIMFIQYVLEKENVGGGSFFVSFLSSGFLEESLKWFILMISVYPHAHFDEHYDGIVY GASVSLGFATLENILYLIGHGVEHAFVRALLPVSCHALIGVIMGFYLGKARFSADKAR VKWLTLSLVVPSLLHGSYDFILTALSNWIYYMLPFMVFLWWFGLRKAKKARSVNMMQV *" /label="prsW CDS" gene complement(2069624..2070280) /gene="prsW" /locus_tag="BSU_22940" /old_locus_tag="BSU22940" /label="prsW gene" downshifts complement(2069638) /Source="Nicolas_upshifts" /id="D1198" /incds=0 /nref=239 /ntot=262 /MaxReadThrough="0.9181" /MaxDrop="6.61797" /score="-3.16364421" /energy="-21.7" /TU="NA" /idTUdmin="U1793" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(2070305..2070324) /Source="Nicolas_upshift_promotors" /id="U1793" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=3121 /SigmaFactorBS="cattcgtatgctctttttgtttttttaagtgcagacagatgt aaaattttaaacaaCATGGTAGGATAGATGTAGGaatataaaggaaagaggttgcctg a" /listShort="prsW" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2070320) /Source="Nicolas_upshifts" /id="U1793" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=3121 /SigmaFactorBS="cattcgtatgctctttttgtttttttaagtgcagacagatgt aaaattttaaacaaCATGGTAGGATAGATGTAGGaatataaaggaaagaggttgcctg a" /listShort="prsW" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2070400..2071374) /gene="ypdA" /locus_tag="BSU_22950" /old_locus_tag="BSU22950" /EC_number="1.8.-.-" /function="16.6: Maintain" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20308541; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative bacillithiol biosynthesis thiol disulfide oxidoreductase" /protein_id="NP_390176.2" /db_xref="EnsemblGenomes-Gn:BSU22950" /db_xref="EnsemblGenomes-Tr:CAB14211" /db_xref="GOA:P50736" /db_xref="InterPro:IPR000103" /db_xref="InterPro:IPR023856" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG11436" /db_xref="UniProtKB/Swiss-Prot:P50736" /translation="MIQEKAIIIGGGPCGLSAAIHLKQIGIDALVIEKGNVVNSIYNY PTHQTFFSSSEKLEIGDVAFITENRKPVRIQALSYYREVVKRKNIRVNAFEMVRKVTK TQNNTFVIETSKETYTTPYCIIATGYYDHPNYMGVPGEDLPKVFHYFKEGHPYFDKDV VVIGGKNSSVDAALELVKSGARVTVLYRGNEYSPSIKPWILPEFEALVRNGTIRMEFG ACVEKITENEVVFRSGEKELITIKNDFVFAMTGYHPDHQFLEKIGVEIDKETGRPFFN EETMETNVEGVFIAGVIAAGNNANEIFIENGRFHGGHIAAEIAKRENH*" /label="ypdA CDS" gene complement(2070400..2071374) /gene="ypdA" /locus_tag="BSU_22950" /old_locus_tag="BSU22950" /label="ypdA gene" downshifts complement(2070408) /Source="Nicolas_upshifts" /id="D1199" /incds=0 /nref=239 /ntot=263 /MaxReadThrough="3.524" /MaxDrop="6.45954" /score="27.4058676" /energy="-12.2" /TU="U1796" /idTUdmin="U1796" /TUdmin="-748" /isTUend="FALSE" /label="downshifts" promotor_-35 2071228..2071233 /Source="Nicolas_upshift_promotors" /id="U1794" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.958041958041958" /psig="0.958041958041958" /xcortree=1114 /SigmaFactorBS="atttcgagcttttcacttgaactgaaaaaGGTTTGatgcgtc gggtaattGTAAATACTGTTAACGACAttgcctttttcgatgacgagggcatcaatgc c" /listShort="S869" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2071249..2071267 /Source="Nicolas_upshift_promotors" /id="U1794" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.958041958041958" /psig="0.958041958041958" /xcortree=1114 /SigmaFactorBS="atttcgagcttttcacttgaactgaaaaaGGTTTGatgcgtc gggtaattGTAAATACTGTTAACGACAttgcctttttcgatgacgagggcatcaatgc c" /listShort="S869" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2071259..2071452 /Source="Nicolas_S_feature" /locus_tag="new_2401843_2402036" /HighExp="S8, S6, S7, S4, S5, C30, S3, BT, B36, C90" /AntisenseName="ypdA" /AntisenseCor="-0.487730736536516" /AntisenseRegPval="-16.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.958" /TUlongSig="NA" /TUlongPSig="NA" /label="S869" upshifts 2071259 /Source="Nicolas_upshifts" /id="U1794" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.958041958041958" /psig="0.958041958041958" /xcortree=1114 /SigmaFactorBS="atttcgagcttttcacttgaactgaaaaaGGTTTGatgcgtc gggtaattGTAAATACTGTTAACGACAttgcctttttcgatgacgagggcatcaatgc c" /listShort="S869" /GFF_Attribute="listLong" /label="upshifts" downshifts 2071410 /Source="Nicolas_upshifts" /id="D1200" /incds=0 /nref=13 /ntot=27 /MaxReadThrough="1.93985" /MaxDrop="5.69954" /score="23.7306175" /energy="-9.3" /TU="NA" /idTUdmin="U1794" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2071483..2072766) /gene="gudB" /locus_tag="BSU_22960" /old_locus_tag="BSU22960" /EC_number="1.4.1.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9829940, 18326565, 22178969, 22720735, 25610436" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9829940, 18326565, 22178969, 22720735, 25610436; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cryptic glutamate dehydrogenase (active after removal of a 9 bp insert)" /protein_id="NP_390177.2" /db_xref="EnsemblGenomes-Gn:BSU22960" /db_xref="EnsemblGenomes-Tr:CAB14212" /db_xref="GOA:P50735" /db_xref="InterPro:IPR006095" /db_xref="InterPro:IPR006096" /db_xref="InterPro:IPR006097" /db_xref="InterPro:IPR014362" /db_xref="InterPro:IPR033524" /db_xref="InterPro:IPR033922" /db_xref="InterPro:IPR036291" /db_xref="PDB:3K8Z" /db_xref="SubtiList:BG11435" /db_xref="UniProtKB/Swiss-Prot:P50735" /translation="MAADRNTGHTEEDKLDVLKSTQTVIHKALEKLGYPEEVYELLKE PMRLLTVKIPVRMDDGSVKIFTGYRAQHNDSVGPTKGGIRFHPNVTEKEVKAVKALSI WMSLKCGIIDLPYGGGKGGIVCDPRDMSFRELERLSRGYVRAISQIVGPTKDVPAPDV FTNSQIMAWMMDEYSRIDEFNSPGFITGKPLVLGGSHGRESATAKGVTICIKEAAKKR GIDIKGARVVVQGFGNAGSYLAKFMHDAGAKVVGISDAYGGLYDPEGLDIDYLLDRRD SFGTVTKLFNDTITNQELLELDCDILVPAAIENQITEENAHNIRAKIVVEAANGPTTL EGTKILSDRDILLVPDVLASAGGVTVSYFEWVQNNQGFYWSEEEVEEKLEKMMVKSFN NIYEMANNRRIDMRLAAYMVGVRKMAEASRFRGWI*" /label="gudB CDS" gene complement(2071483..2072766) /gene="gudB" /locus_tag="BSU_22960" /old_locus_tag="BSU22960" /label="gudB gene" downshifts complement(2071486) /Source="Nicolas_upshifts" /id="D1201" /incds=0 /nref=2 /ntot=54 /MaxReadThrough="7.92262" /MaxDrop="4.04542" /score="18.1400723" /energy="-9.3" /TU="U1796" /idTUdmin="U1797" /TUdmin=1345 /isTUend="FALSE" /label="downshifts" promotor_-35 2071524..2071530 /Source="Nicolas_upshift_promotors" /id="U1795" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.001998001998002" /xcortree=59 /SigmaFactorBS="cttatatccagcctctaaaacgcgaagcttcagccattttgc GAACGCCgaccatatatgCAGCGagcctcatgtcaattcttcggttgttagccatttc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2071542..2071546 /Source="Nicolas_upshift_promotors" /id="U1795" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.001998001998002" /xcortree=59 /SigmaFactorBS="cttatatccagcctctaaaacgcgaagcttcagccattttgc GAACGCCgaccatatatgCAGCGagcctcatgtcaattcttcggttgttagccatttc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2071542 /Source="Nicolas_upshifts" /id="U1795" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.001998001998002" /xcortree=59 /SigmaFactorBS="cttatatccagcctctaaaacgcgaagcttcagccattttgc GAACGCCgaccatatatgCAGCGagcctcatgtcaattcttcggttgttagccatttc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2072809..2072828) /Source="Nicolas_upshift_promotors" /id="U1796" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.716283716283716" /psig="0.972027972027972" /xcortree=2225 /SigmaFactorBS="ttttttttcgttaaaaaacatggaaaaacataacgtttatTC TATGCAcagatcatatgaagGTGTATACTATTCTCTGAAAgggagcatgtgagaaaca g" /listShort="gudB, ypdA, prsW" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2072830) /Source="Nicolas_upshifts" /id="U1796" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.716283716283716" /psig="0.972027972027972" /xcortree=2225 /SigmaFactorBS="ttttttttcgttaaaaaacatggaaaaacataacgtttatTC TATGCAcagatcatatgaagGTGTATACTATTCTCTGAAAgggagcatgtgagaaaca g" /listShort="gudB, ypdA, prsW" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2072843..2072850) /Source="Nicolas_upshift_promotors" /id="U1796" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.716283716283716" /psig="0.972027972027972" /xcortree=2225 /SigmaFactorBS="ttttttttcgttaaaaaacatggaaaaacataacgtttatTC TATGCAcagatcatatgaagGTGTATACTATTCTCTGAAAgggagcatgtgagaaaca g" /listShort="gudB, ypdA, prsW" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2072922..2073506) /gene="mecB" /locus_tag="BSU_22970" /old_locus_tag="BSU22970" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11914365, 19801546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11914365, 19801546; Product type f: factor" /codon_start=1 /transl_table=11 /product="adaptor to ClpC; regulator of competence and sporulation" /protein_id="NP_390178.1" /db_xref="EnsemblGenomes-Gn:BSU22970" /db_xref="EnsemblGenomes-Tr:CAB14213" /db_xref="GOA:P50734" /db_xref="InterPro:IPR008681" /db_xref="PDB:3JTN" /db_xref="PDB:3JTO" /db_xref="SubtiList:BG11434" /db_xref="UniProtKB/Swiss-Prot:P50734" /translation="MRLERLNYNKIKIFLTLDDLTDRGLTKEDLWKDSFKVHQLFKDM MNEANTELGFEANGPIAVEVYSLQAQGMVVIVTKNQDADSEDDEYDDDYIEMQVKLDE SADIIYQFHSFEDIIQLSESLQRIGITGGTVYHYDGQYFLSLEDLGSHTAEGVVAVLA EYGNPTTLTIYRLQEYGKLIMDGNAVETIQTHFS*" /label="mecB CDS" gene complement(2072922..2073506) /gene="mecB" /locus_tag="BSU_22970" /old_locus_tag="BSU22970" /label="mecB gene" downshifts complement(2072924) /Source="Nicolas_upshifts" /id="D1202" /incds=0 /nref=258 /ntot=274 /MaxReadThrough="3.02006" /MaxDrop="7.92719" /score="23.8885529" /energy="-7.1" /TU="U1797" /idTUdmin="U1797" /TUdmin="-93" /isTUend="FALSE" /label="downshifts" S_feature complement(2073507..2073588) /Source="Nicolas_S_feature" /locus_tag="new_2404091_2404172_c" /HighExp="dia5, Diami, Etha, dia15, C90, Salt, LPhT, Heat, MG-0.2, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigWXY" /TUlongPSig=1 /label="S870" promotor_-10 complement(2073581..2073600) /Source="Nicolas_upshift_promotors" /id="U1797" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=638 /SigmaFactorBS="atccgtatggcaataaaaactgcattgTGCTTGTCttactag tgaactCAGTGTAAACTGATAACAATtaagaacctatgactcatcatctcatataatg t" /listShort="S870, mecB" /listLong="gudB, ypdA" /label="promotor_-10" upshifts complement(2073588) /Source="Nicolas_upshifts" /id="U1797" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=638 /SigmaFactorBS="atccgtatggcaataaaaactgcattgTGCTTGTCttactag tgaactCAGTGTAAACTGATAACAATtaagaacctatgactcatcatctcatataatg t" /listShort="S870, mecB" /listLong="gudB, ypdA" /label="upshifts" promotor_-35 complement(2073614..2073621) /Source="Nicolas_upshift_promotors" /id="U1797" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=638 /SigmaFactorBS="atccgtatggcaataaaaactgcattgTGCTTGTCttactag tgaactCAGTGTAAACTGATAACAATtaagaacctatgactcatcatctcatataatg t" /listShort="S870, mecB" /listLong="gudB, ypdA" /label="promotor_-35" CDS complement(2073665..2074444) /gene="ypbG" /locus_tag="BSU_22980" /old_locus_tag="BSU22980" /EC_number="3.1.-.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15838020, 17434969; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphoesterase" /protein_id="NP_390179.1" /db_xref="EnsemblGenomes-Gn:BSU22980" /db_xref="EnsemblGenomes-Tr:CAB14214" /db_xref="GOA:P50733" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG11433" /db_xref="UniProtKB/Swiss-Prot:P50733" /translation="MKLSVKIAGVLTVAAAAMTAKMYATAKGNHLKTHTFPLSKMKGK PPLTIFFISDIHKRLIDQDLLEKARSHAPHLVIIGGDLAEGGVPSARIEENIKRLVHF GVPIVFVWGNNDYEVRQHKLYSIFKAHGVITLRNESVPFSYNGHTIAIAGVDDIRMEM DHYEEAIKELDESQLNILVCHNPEIHEQINEDDGIDVILSGHTHGGQIRFGKFGPYEL GKTGIVKNAAYLISNGYGTTKVPLRLGAEPETHIVTLCGPE*" /label="ypbG CDS" gene complement(2073665..2074444) /gene="ypbG" /locus_tag="BSU_22980" /old_locus_tag="BSU22980" /label="ypbG gene" promotor_-10 complement(2074470..2074485) /Source="Nicolas_upshift_promotors" /id="U1798" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1649 /SigmaFactorBS="gaaagtaaataaaatggggcgttttctcaaacgatAGAAACG TCTttttttattgtCCGTCTTATTGATAAGttctaaaaagaatggagagttttttatg a" /listShort="ypbG" /listLong="S870, mecB" /label="promotor_-10" upshifts complement(2074481) /Source="Nicolas_upshifts" /id="U1798" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1649 /SigmaFactorBS="gaaagtaaataaaatggggcgttttctcaaacgatAGAAACG TCTttttttattgtCCGTCTTATTGATAAGttctaaaaagaatggagagttttttatg a" /listShort="ypbG" /listLong="S870, mecB" /label="upshifts" promotor_-35 complement(2074497..2074506) /Source="Nicolas_upshift_promotors" /id="U1798" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1649 /SigmaFactorBS="gaaagtaaataaaatggggcgttttctcaaacgatAGAAACG TCTttttttattgtCCGTCTTATTGATAAGttctaaaaagaatggagagttttttatg a" /listShort="ypbG" /listLong="S870, mecB" /label="promotor_-35" CDS complement(2074530..2074973) /gene="ypbF" /locus_tag="BSU_22990" /old_locus_tag="BSU22990" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390180.1" /db_xref="EnsemblGenomes-Gn:BSU22990" /db_xref="EnsemblGenomes-Tr:CAB14215" /db_xref="GOA:P50732" /db_xref="InterPro:IPR020210" /db_xref="SubtiList:BG11432" /db_xref="UniProtKB/Swiss-Prot:P50732" /translation="MESLWNQLDQFTDAPTKQMLQALVKRKQKFENYAAQCRRWRWAS LICLGLLCVMIMIKSPEPQLILQEILSHTFYLFWMLATAFAYCTSYYFKKKEEKSETD FHKLRCEIIQKSTDLWPQPDKWKARESVFHMMKHKYDINLYFESK*" /label="ypbF CDS" gene complement(2074530..2074973) /gene="ypbF" /locus_tag="BSU_22990" /old_locus_tag="BSU22990" /label="ypbF gene" downshifts complement(2074547) /Source="Nicolas_upshifts" /id="D1203" /incds=0 /nref=4 /ntot=112 /MaxReadThrough="4.67294" /MaxDrop="3.33254" /score="6.86206051" /energy="-7.5" /TU="U1801" /idTUdmin="U1799" /TUdmin=22 /isTUend="TRUE" /label="downshifts" CDS complement(2075036..2075758) /gene="ypbE" /locus_tag="BSU_23000" /old_locus_tag="BSU23000" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16855244, 22950025; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme possibly involved in cell wall turnover" /protein_id="NP_390181.1" /db_xref="EnsemblGenomes-Gn:BSU23000" /db_xref="EnsemblGenomes-Tr:CAB14216" /db_xref="GOA:P50731" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG11431" /db_xref="UniProtKB/Swiss-Prot:P50731" /translation="MTNMSRVERRKAQNLYEDQNAALADDYVDDGESLPTRQSVKNQR EQKKKQGKTKTPLFTVLAVIFVFVPVIVLVTLFYLKSHPDNHDDYEDVFIDSSQSKYE VVPKSEDKNDTADTKETALQKESKKEPEDSKPKEQTAADKKQTAVAEKEDSPNKEEAT AAAASSSQSTVQQQEQPAEPVQNVPNRVVKHTVQKKETLYRISMKYYKSRTGEEKIRA YNHLNGNDVYTGQVLDIPLMDE*" /label="ypbE CDS" gene complement(2075036..2075758) /gene="ypbE" /locus_tag="BSU_23000" /old_locus_tag="BSU23000" /label="ypbE gene" downshifts complement(2075317) /Source="Nicolas_upshifts" /id="D1204" /incds=1 /nref=4 /ntot=93 /MaxReadThrough="4.30678" /MaxDrop="3.33147" /score="6.86206051" /energy="-7.5" /TU="U1799,U1801" /idTUdmin="U1799" /TUdmin="-748" /isTUend="FALSE" /label="downshifts" CDS complement(2075709..2076278) /gene="ypbD" /locus_tag="BSU_23010" /old_locus_tag="BSU23010" /function="16.6: Maintain" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_390182.1" /db_xref="EnsemblGenomes-Gn:BSU23010" /db_xref="EnsemblGenomes-Tr:CAB14217" /db_xref="GOA:P50730" /db_xref="InterPro:IPR003675" /db_xref="SubtiList:BG11430" /db_xref="UniProtKB/Swiss-Prot:P50730" /translation="MTQLLIIFAAAAAGLFFFEDVRDVLKLWDIRDMRIIWYGVSIAV IVILADMAVMKWFPSHLYDDGGINKKIFSKRSIPHIIFLTLLIAFAEEMLFRGVLQTH IGLWTASLIFAALHFRYLSKWLLFIMVTAISFLLGLMYEWTGNLFVPMTAHFIIDAVF ACQIRFEHVRRDKHDEHVESREKKSPESL*" /label="ypbD CDS" gene complement(2075709..2076278) /gene="ypbD" /locus_tag="BSU_23010" /old_locus_tag="BSU23010" /label="ypbD gene" promotor_-10 complement(2076027..2076045) /Source="Nicolas_upshift_promotors" /id="U1799" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.466533466533467" /psig="0.466533466533467" /xcortree=1458 /SigmaFactorBS="ctcatttatatgatgacggcggaatcaataaaaaaatATTCA GTaagaggtcaatcccTCATATTATATTTTTAACGcttctgattgctttcgcggaaga a" /listShort="ypbE, ypbF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2076043) /Source="Nicolas_upshifts" /id="U1799" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.466533466533467" /psig="0.466533466533467" /xcortree=1458 /SigmaFactorBS="ctcatttatatgatgacggcggaatcaataaaaaaatATTCA GTaagaggtcaatcccTCATATTATATTTTTAACGcttctgattgctttcgcggaaga a" /listShort="ypbE, ypbF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2076060..2076066) /Source="Nicolas_upshift_promotors" /id="U1799" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.466533466533467" /psig="0.466533466533467" /xcortree=1458 /SigmaFactorBS="ctcatttatatgatgacggcggaatcaataaaaaaatATTCA GTaagaggtcaatcccTCATATTATATTTTTAACGcttctgattgctttcgcggaaga a" /listShort="ypbE, ypbF" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2076297..2077043 /Source="Nicolas_S_feature" /locus_tag="new_2406881_2407627" /HighExp="S6, S8, S7, C30, BT, S5, C90, Pyr, BC, Sw" /AntisenseName="recQ" /AntisenseCor="-0.47918253719211501" /AntisenseRegPval="-16.100000000000001" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S871" CDS complement(2076338..2077828) /gene="recS" /locus_tag="BSU_23020" /old_locus_tag="BSU23020" /EC_number="3.6.1.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16385024, 25246477, 26001966, 28527403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16385024, 25246477, 26001966, 28527403; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent DNA helicase" /protein_id="NP_390183.1" /db_xref="EnsemblGenomes-Gn:BSU23020" /db_xref="EnsemblGenomes-Tr:CAB14218" /db_xref="GOA:P50729" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR002464" /db_xref="InterPro:IPR004589" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11407" /db_xref="UniProtKB/Swiss-Prot:P50729" /translation="MTKLQQTLYQFFGFTSFKKGQQDIIESILSGKDTIAMLPTGGGK SLCYQLPGYMLDGMVLIVSPLLSLMEDQVQQLKARGEKRAAALNSMLNRQERQFVLEH IHRYKFLYLSPEALQSPYVLEKLKSVPISLFVIDEAHCISEWGHDFRPDYSKLGQLRK KLGHPPVLALTATATKETLQDVMNLLELQHAVRHLNSVNRPNIALRVENAADTAEKID RVIQLVENLQGPGIVYCPTRKWAKELAGEIKSKTSSRADFYHGGLESGDRILIQQQFI HNQLDVICCTNAFGMGVDKPDIRYVIHFHLPQTAEAFMQEIGRAGRDGKPSVSILLRA PGDFELQEQIIQMESVTAEEIADVIRVLEKTEERDERRLRDVLLQYGVGETQARMMIH LFMQGKTSVELMKKEISYRMELKLEKMHRVSFLLQRDGCLRQALLTYFDESYEPDDGN LPCCSHCGFDLSLYEQKGERSKMAPLDSWSSELHRIFSLQTVGELN*" /label="recS CDS" gene complement(2076338..2077828) /gene="recS" /locus_tag="BSU_23020" /old_locus_tag="BSU23020" /label="recS gene" CDS complement(2077821..2078879) /gene="gmmB" /locus_tag="BSU_23030" /old_locus_tag="BSU23030" /experiment="publication(s) with functional evidences, PMID:21170359" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21170359; Product type f: factor" /codon_start=1 /transl_table=11 /product="subunit of the platform for genome maintenance machinery" /protein_id="NP_390184.1" /db_xref="EnsemblGenomes-Gn:BSU23030" /db_xref="EnsemblGenomes-Tr:CAB14219" /db_xref="InterPro:IPR008308" /db_xref="InterPro:IPR029491" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11429" /db_xref="UniProtKB/Swiss-Prot:P50728" /translation="MSLNYFDIMVLDCLCKINGERSGSAVFHLFKGKRSSQTIQDAGL FQTAKYFGMAAKCSRSDISASLDKLEKHSYLAPMSESDTYKVTASGAAVLRHALSERP WPVHCHGAHYQQAAGVLWKRLSLLVQVLSHKQQGSRQYIPVTKDHKTLHWVKKYLSRH TDHIEMAKSLFAMLEAHLKKIENKAAQIFVYSLTSHHRIGYTSRQLADTLKEDEWYVY IMFWASVHYFIHSLPECEDALLKDLLSDVHLDNALTESTRKTWQMVKQGFPIQRIAEI RKLKTATIEDHIVEISLHEPAFMINDYVSAEDQLQIAEFAKRMRTNKIKQIRDGLEQR FSYFQIRLALTKQVQQYD*" /label="gmmB CDS" gene complement(2077821..2078879) /gene="gmmB" /locus_tag="BSU_23030" /old_locus_tag="BSU23030" /label="gmmB gene" promotor_-35 2078169..2078178 /Source="Nicolas_upshift_promotors" /id="U1800" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1318 /SigmaFactorBS="tatctaagtgcacatcagaaaggagatcctttaacaaagcAT CTTCACACtccggaagagaaTGAATAAAATAATGTACCGAagcccaaaacatgatata g" /listShort="S872, S873, S874, fer" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2078189..2078979 /Source="Nicolas_S_feature" /locus_tag="new_2408773_2409563" /HighExp="S8, S6, S7, S5, BT, B36, Pyr, G/S, B60, nit" /AntisenseName="ypbB" /AntisenseCor="-0.76734368116597995" /AntisenseRegPval="-52.7" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S872" upshifts 2078189 /Source="Nicolas_upshifts" /id="U1800" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1318 /SigmaFactorBS="tatctaagtgcacatcagaaaggagatcctttaacaaagcAT CTTCACACtccggaagagaaTGAATAAAATAATGTACCGAagcccaaaacatgatata g" /listShort="S872, S873, S874, fer" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2078191..2078210 /Source="Nicolas_upshift_promotors" /id="U1800" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1318 /SigmaFactorBS="tatctaagtgcacatcagaaaggagatcctttaacaaagcAT CTTCACACtccggaagagaaTGAATAAAATAATGTACCGAagcccaaaacatgatata g" /listShort="S872, S873, S874, fer" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2078920..2078939) /Source="Nicolas_upshift_promotors" /id="U1801" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.926073926073926" /psig="0.993006993006993" /xcortree=2277 /SigmaFactorBS="ataaggggttatctacataacatcccccttaatgatgacttt aaaCGTCGATTtctgtttgaaaTCTGTTAAAATAAAAAGAGCaaatcaacgatttttg t" /listShort="ypbB, recQ, ypbD, ypbE, ypbF, ypbG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2078943) /Source="Nicolas_upshifts" /id="U1801" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.926073926073926" /psig="0.993006993006993" /xcortree=2277 /SigmaFactorBS="ataaggggttatctacataacatcccccttaatgatgacttt aaaCGTCGATTtctgtttgaaaTCTGTTAAAATAAAAAGAGCaaatcaacgatttttg t" /listShort="ypbB, recQ, ypbD, ypbE, ypbF, ypbG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2078951..2078958) /Source="Nicolas_upshift_promotors" /id="U1801" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.926073926073926" /psig="0.993006993006993" /xcortree=2277 /SigmaFactorBS="ataaggggttatctacataacatcccccttaatgatgacttt aaaCGTCGATTtctgtttgaaaTCTGTTAAAATAAAAAGAGCaaatcaacgatttttg t" /listShort="ypbB, recQ, ypbD, ypbE, ypbF, ypbG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2078957..2078963 /Source="Nicolas_upshift_promotors" /id="U1802" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=115 /SigmaFactorBS="ctctttttattttaacagatttcaaacagaaatcgaCGTTTA AagtcatcattaagGGGGATGTTATGTAGATAACcccttatgtgataagcattctcaa t" /listShort="S873" /listLong="S874, fer" /label="promotor_-35" promotor_-10 2078977..2078996 /Source="Nicolas_upshift_promotors" /id="U1802" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=115 /SigmaFactorBS="ctctttttattttaacagatttcaaacagaaatcgaCGTTTA AagtcatcattaagGGGGATGTTATGTAGATAACcccttatgtgataagcattctcaa t" /listShort="S873" /listLong="S874, fer" /label="promotor_-10" S_feature 2078981..2079050 /Source="Nicolas_S_feature" /locus_tag="new_2409565_2409634" /HighExp="S6, S8, S7, S5, BT, B36, C30, Pyr, B60, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigK" /TUshortPSig="0.991, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S873" upshifts 2078981 /Source="Nicolas_upshifts" /id="U1802" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=115 /SigmaFactorBS="ctctttttattttaacagatttcaaacagaaatcgaCGTTTA AagtcatcattaagGGGGATGTTATGTAGATAACcccttatgtgataagcattctcaa t" /listShort="S873" /listLong="S874, fer" /label="upshifts" promotor_-35 2079030..2079037 /Source="Nicolas_upshift_promotors" /id="U1803" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.692307692307692" /psig=1 /xcortree=1751 /SigmaFactorBS="ataaccccttatgtgataagcattctcaatcatttttcTGTT GAAAtgtggcagcaacatCATTACAATAAGTAAGAGGAataggtgttaaattgattaa a" /listShort="S874, fer" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2079052..2079144 /Source="Nicolas_S_feature" /locus_tag="new_2409636_2409728" /HighExp="LPhT, LBGstat, HPh, C90, LBGtran, C30, Lbtran, Cold, LPh, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="1, 0.996" /TUlongSig="SigB" /TUlongPSig="0.991" /label="S874" promotor_-10 2079052..2079071 /Source="Nicolas_upshift_promotors" /id="U1803" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.692307692307692" /psig=1 /xcortree=1751 /SigmaFactorBS="ataaccccttatgtgataagcattctcaatcatttttcTGTT GAAAtgtggcagcaacatCATTACAATAAGTAAGAGGAataggtgttaaattgattaa a" /listShort="S874, fer" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2079052 /Source="Nicolas_upshifts" /id="U1803" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.692307692307692" /psig=1 /xcortree=1751 /SigmaFactorBS="ataaccccttatgtgataagcattctcaatcatttttcTGTT GAAAtgtggcagcaacatCATTACAATAAGTAAGAGGAataggtgttaaattgattaa a" /listShort="S874, fer" /GFF_Attribute="listLong" /label="upshifts" CDS 2079145..2079393 /gene="fer" /locus_tag="BSU_23040" /old_locus_tag="BSU23040" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12538057, 21665975" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12538057, 21665975; Product type c: carrier" /codon_start=1 /transl_table=11 /product="ferredoxin" /protein_id="NP_390185.1" /db_xref="EnsemblGenomes-Gn:BSU23040" /db_xref="EnsemblGenomes-Tr:CAB14220" /db_xref="GOA:P50727" /db_xref="InterPro:IPR001080" /db_xref="InterPro:IPR017896" /db_xref="SubtiList:BG11388" /db_xref="UniProtKB/Swiss-Prot:P50727" /translation="MAKYTIVDKDTCIACGACGAAAPDIYDYDDEGIAFVTLDENKGV VEVPEVLEEDMIDAFEGCPTDSIKVADEPFEGDPLKFE*" /label="fer CDS" gene 2079145..2079393 /gene="fer" /locus_tag="BSU_23040" /old_locus_tag="BSU23040" /label="fer gene" downshifts 2079377 /Source="Nicolas_upshifts" /id="D1205" /incds=0 /nref=221 /ntot=291 /MaxReadThrough="3.16016" /MaxDrop="8.38074" /score="34.9672707" /energy="-9.9" /TU="U1803" /idTUdmin="U1800" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2079433..2080005) /gene="fmnP" /locus_tag="BSU_23050" /old_locus_tag="BSU23050" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12456892, 15849754, 16850406, 17693491, 25438558" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12456892, 15849754, 16850406, 17693491, 25438558; Product type t : transporter" /codon_start=1 /transl_table=11 /product="FMN permease" /protein_id="NP_390186.1" /db_xref="EnsemblGenomes-Gn:BSU23050" /db_xref="EnsemblGenomes-Tr:CAB14237" /db_xref="GOA:P50726" /db_xref="InterPro:IPR024529" /db_xref="InterPro:IPR025720" /db_xref="SubtiList:BG11428" /db_xref="UniProtKB/Swiss-Prot:P50726" /translation="MKVKKLVVVSMLSSIAFVLMLLNFPFPGLPDYLKIDFSDVPAII AILIYGPLAGIAVEAIKNVLQYIIQGSMAGVPVGQVANFIAGTLFILPTAFLFKKLNS AKGLAVSLLLGTAAMTILMSILNYVLILPAYTWFLHSPALSDSALKTAVVAGILPFNM IKGIVITVVFSLIFIKLKPWIEQQRSAHIH*" /label="fmnP CDS" gene complement(2079433..2080005) /gene="fmnP" /locus_tag="BSU_23050" /old_locus_tag="BSU23050" /label="fmnP gene" downshifts complement(2079453) /Source="Nicolas_upshifts" /id="D1206" /incds=0 /nref=103 /ntot=231 /MaxReadThrough="2.60651" /MaxDrop="4.95518" /score="35.0684207" /energy="-9.9" /TU="NA" /idTUdmin="U1804" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_RNA complement(2079997..2080304) /gene="fswB" /locus_tag="BSU_misc_RNA_78" /product="flavin mononucleotide riboswitch" /experiment="publication(s) with functional evidences, PMID:12456892, 15808508" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12456892, 15808508; Product type n: RNA" /label="fswB RNA" gene complement(2079997..2080304) /gene="fswB" /locus_tag="BSU_misc_RNA_78" /label="fswB gene" S_feature complement(2080006..2080110) /Source="Nicolas_S_feature" /locus_tag="new_2410590_2410694_c" /HighExp="S1, LPhT, M9-stat, B60, Heat, T0.30H, Gly, S5, BC, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S875" promotor_-10 complement(2080303..2080322) /Source="Nicolas_upshift_promotors" /id="U1804" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.425574425574426" /psig=1 /xcortree=605 /SigmaFactorBS="acagcttgcaggtaatatatttaatttgaagcaattcTCTAT ACagccaaccagttaTCGTTTATAATGTAATTAAAtttcatatgatcaatcttcgggg c" /listShort="ypzE, S875, fmnP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2080319) /Source="Nicolas_upshifts" /id="U1804" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.425574425574426" /psig=1 /xcortree=605 /SigmaFactorBS="acagcttgcaggtaatatatttaatttgaagcaattcTCTAT ACagccaaccagttaTCGTTTATAATGTAATTAAAtttcatatgatcaatcttcgggg c" /listShort="ypzE, S875, fmnP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2080336..2080342) /Source="Nicolas_upshift_promotors" /id="U1804" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.425574425574426" /psig=1 /xcortree=605 /SigmaFactorBS="acagcttgcaggtaatatatttaatttgaagcaattcTCTAT ACagccaaccagttaTCGTTTATAATGTAATTAAAtttcatatgatcaatcttcgggg c" /listShort="ypzE, S875, fmnP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2080431..2080438 /Source="Nicolas_upshift_promotors" /id="U1805" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.887112887112887" /psig="0.995004995004995" /xcortree=3067 /SigmaFactorBS="gatttattaggctttacttttatcctttactgcgtcaataca CGTTGACActcttttgagaataTGTTAAATTATCAGATATTTagtttgtcaatttagg a" /listShort="serA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2080449 /Source="Nicolas_upshifts" /id="U1805" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.887112887112887" /psig="0.995004995004995" /xcortree=3067 /SigmaFactorBS="gatttattaggctttacttttatcctttactgcgtcaataca CGTTGACActcttttgagaataTGTTAAATTATCAGATATTTagtttgtcaatttagg a" /listShort="serA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2080453..2080472 /Source="Nicolas_upshift_promotors" /id="U1805" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.887112887112887" /psig="0.995004995004995" /xcortree=3067 /SigmaFactorBS="gatttattaggctttacttttatcctttactgcgtcaataca CGTTGACActcttttgagaataTGTTAAATTATCAGATATTTagtttgtcaatttagg a" /listShort="serA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2080502..2082079 /gene="serA" /locus_tag="BSU_23070" /old_locus_tag="BSU23070" /EC_number="1.1.1.95" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:168067, 11390694, 17611193, 4337849, 21749987, 22938038, 28827360" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 168067, 11390694, 17611193, 4337849, 21749987, 22938038, 28827360; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-phosphoglycerate dehydrogenase" /protein_id="NP_390188.2" /db_xref="EnsemblGenomes-Gn:BSU23070" /db_xref="EnsemblGenomes-Tr:CAB14239" /db_xref="GOA:P35136" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR006139" /db_xref="InterPro:IPR006140" /db_xref="InterPro:IPR006236" /db_xref="InterPro:IPR029009" /db_xref="InterPro:IPR029752" /db_xref="InterPro:IPR029753" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10509" /db_xref="UniProtKB/Swiss-Prot:P35136" /translation="MFRVLVSDKMSNDGLQPLIESDFIEIVQKNVADAEDELHTFDAL LVRSATKVTEDLFNKMTSLKIVGRAGVGVDNIDIDEATKHGVIVINAPNGNTISTAEH TFAMISSLMRHIPQANISVKSREWNRTAYVGSELYGKTLGIVGLGRIGSEIAQRARAF GMTVHVFDPFLTEERAKKIGVNSRTFEEVLESADIITVHTPLTKETKGLLNKETIAKT KKGVRLINCARGGIIDEAALLEALENGHVAGAALDVFEVEPPVDNKLVDHPLVIATPH LGASTKEAQLNVAAQVSEEVLQFAKGLPVMSAINLPAMTKDEFAKIKPYHQIAGKIGS LVSQCMKEPVQDVAIQYEGTIAKLETSFITKALLSGFLKPRVDSTVNEVNAGGVAKER GISFSEKISSSESGYDNCISVKVTGDRSTFTVTATYIPHFGERIVEINGFNIDFYPTG HLVYIQHQDTTGVIGRVGRILGDNDINIATMQVGRKEKGGEAIMMLSFDRHLEDKIVK ELTNVPDIVSVKLIDLP*" /label="serA CDS" gene 2080502..2082079 /gene="serA" /locus_tag="BSU_23070" /old_locus_tag="BSU23070" /label="serA gene" downshifts 2082061 /Source="Nicolas_upshifts" /id="D1207" /incds=0 /nref=246 /ntot=311 /MaxReadThrough="3.23011" /MaxDrop="8.29454" /score="32.0086708" /energy="-10.2" /TU="U1805" /idTUdmin="U1805" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" CDS complement(2082122..2082889) /gene="aroC" /locus_tag="BSU_23080" /old_locus_tag="BSU23080" /EC_number="4.2.1.10" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6442253" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6442253; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="3-dehydroquinate dehydratase" /protein_id="NP_390189.1" /db_xref="EnsemblGenomes-Gn:BSU23080" /db_xref="EnsemblGenomes-Tr:CAB14240" /db_xref="GOA:P35146" /db_xref="InterPro:IPR001381" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR018508" /db_xref="SubtiList:BG10538" /db_xref="UniProtKB/Swiss-Prot:P35146" /translation="MNVLTIKGVSIGEGMPKIIIPLMGKTEKQILNEAEAVKLLNPDI VEWRVDVFEKANDREAVTKLISKLRKSLEDKLFLFTFRTHKEGGSMEMDESSYLALLE SAIQTKDIDLIDIELFSGDANVKALVSLAEENNVYVVMSNHDFEKTPVKDEIISRLRK MQDLGAHIPKMAVMPNDTGDLLTLLDATYTMKTIYADRPIITMSMAATGLISRLSGEV FGSACTFGAGEEASAPGQIPVSELRSVLDILHKNTRG*" /label="aroC CDS" gene complement(2082122..2082889) /gene="aroC" /locus_tag="BSU_23080" /old_locus_tag="BSU23080" /label="aroC gene" downshifts complement(2082137) /Source="Nicolas_upshifts" /id="D1208" /incds=0 /nref=152 /ntot=231 /MaxReadThrough="2.53428" /MaxDrop="5.12103" /score="24.3727755" /energy="-10.2" /TU="NA" /idTUdmin="U1806" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 2082391..2083003 /Source="Nicolas_S_feature" /locus_tag="new_2412975_2413587" /HighExp="B36, C30, LoTm, B60, C90, HiOs, BI, Sw, T1.0H, BT" /AntisenseName="aroC" /AntisenseCor="4.7354591214804703E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S876" promotor_-10 complement(2082916..2082935) /Source="Nicolas_upshift_promotors" /id="U1806" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2283 /SigmaFactorBS="taaggctcttttttagttgctattcatataatagaaATTTtc aaaaaaaagttgTACGTGTATAATAAAACAAGgtaaagattgaaaggatttgagacga g" /listShort="aroC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2082929) /Source="Nicolas_upshifts" /id="U1806" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2283 /SigmaFactorBS="taaggctcttttttagttgctattcatataatagaaATTTtc aaaaaaaagttgTACGTGTATAATAAAACAAGgtaaagattgaaaggatttgagacga g" /listShort="aroC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2082950..2082953) /Source="Nicolas_upshift_promotors" /id="U1806" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2283 /SigmaFactorBS="taaggctcttttttagttgctattcatataatagaaATTTtc aaaaaaaagttgTACGTGTATAATAAAACAAGgtaaagattgaaaggatttgagacga g" /listShort="aroC" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2082963 /Source="Nicolas_upshifts" /id="D1209" /incds=0 /nref=10 /ntot=52 /MaxReadThrough="2.02363" /MaxDrop="5.64228" /score="10.7892325" /energy="-8.5" /TU="NA" /idTUdmin="U1805" /TUdmin=704 /isTUend="FALSE" /label="downshifts" CDS complement(2083001..2084107) /gene="rsiX" /locus_tag="BSU_23090" /old_locus_tag="BSU23090" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9139908, 9393439, 10712692, 14762009, 16306698" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9139908, 9393439, 10712692, 14762009, 16306698; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of sigma(X) activity" /protein_id="NP_390190.2" /db_xref="EnsemblGenomes-Gn:BSU23090" /db_xref="EnsemblGenomes-Tr:CAB14241" /db_xref="GOA:P35166" /db_xref="InterPro:IPR019606" /db_xref="SubtiList:BG10537" /db_xref="UniProtKB/Swiss-Prot:P35166" /translation="MMKSEWNEEQIKELLSQLPAVKDHRSPQDIYKRLTMAKRKNKPA VRWIGPACAAAIAVYIAFIISPHFFDQAQPQQKEASQENAVTKTETEDSPKAASSLDQ TSFVVPEKEQDNYITVAVADADTSAIIPVSIQKTNADQTIQDMLFESSELGILDHAIT IPTFIDEVEIKEKPKQKELSIRVHQPATAFSIKDDTLLKKLLKESLKWSPYEKVKFLS DQNETGVRIGSYGTFTEISIPKQSKRSYYLYQNKQGQDFLVPSNHSFDTVKEAIKEME SSSQEDTTPLIQAGAVQSVTKKQKHLYIRFSKESEVDDSIAGILMIEGLLLTAKEFGF TEVTFTETRTKKIGKYDISDAIPVPAAPNPISLN*" /label="rsiX CDS" gene complement(2083001..2084107) /gene="rsiX" /locus_tag="BSU_23090" /old_locus_tag="BSU23090" /label="rsiX gene" downshifts complement(2083018) /Source="Nicolas_upshifts" /id="D1210" /incds=0 /nref=155 /ntot=242 /MaxReadThrough="3.84557" /MaxDrop="5.30684" /score="7.9467954" /energy="-6.7" /TU="U1809" /idTUdmin="U1806" /TUdmin="-881" /isTUend="FALSE" /label="downshifts" CDS complement(2084043..2084627) /gene="sigX" /locus_tag="BSU_23100" /old_locus_tag="BSU23100" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9636707, 11222589, 12399481, 14762009, 19767430, 27965645" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9636707, 11222589, 12399481, 14762009, 19767430, 27965645; Product type r : regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase ECF(extracytoplasmic function)-type sigma factor sigma(X)" /protein_id="NP_390191.2" /db_xref="EnsemblGenomes-Gn:BSU23100" /db_xref="EnsemblGenomes-Tr:CAB14242" /db_xref="GOA:P35165" /db_xref="InterPro:IPR000838" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10536" /db_xref="UniProtKB/Swiss-Prot:P35165" /translation="MEETFQLLYDTYHQDLYQFLFYMVKDKNQTEDLLQEVYIRVLNS YHTFEGRSSEKTWLLSIARHVAIDWFRKQQTIRQRILGTFDWDTQDVRDQQLLPDELA VQHENVREIYAALDQCTIDQRAVIILRFIQGYSIQETAKALRFSESKVKTTQHRGLKV LRKHMELLREELMDDEVRMERRTDKGVVKSTSGS*" /label="sigX CDS" gene complement(2084043..2084627) /gene="sigX" /locus_tag="BSU_23100" /old_locus_tag="BSU23100" /label="sigX gene" promotor_-35 2084421..2084426 /Source="Nicolas_upshift_promotors" /id="U1807" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95004995004995" /psig="0.018981018981019" /xcortree=30 /SigmaFactorBS="aatgtaccgagtatacgctgtctgattgtttgctgtttacgg aaCCAGTCtatcgcaacatggcGTGCGatagacaaaagccatgttttttcactgcttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2084437 /Source="Nicolas_upshifts" /id="U1807" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95004995004995" /psig="0.018981018981019" /xcortree=30 /SigmaFactorBS="aatgtaccgagtatacgctgtctgattgtttgctgtttacgg aaCCAGTCtatcgcaacatggcGTGCGatagacaaaagccatgttttttcactgcttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2084441..2084445 /Source="Nicolas_upshift_promotors" /id="U1807" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95004995004995" /psig="0.018981018981019" /xcortree=30 /SigmaFactorBS="aatgtaccgagtatacgctgtctgattgtttgctgtttacgg aaCCAGTCtatcgcaacatggcGTGCGatagacaaaagccatgttttttcactgcttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2084578..2084583 /Source="Nicolas_upshift_promotors" /id="U1808" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1055 /SigmaFactorBS="ttctgtctggtttttatcctttaccatataaaataaaaattg gTACAAAtcttgatgatatgtaTCATATAATAATTGAAAGGtttcttccatttgaaac c" /listShort="S877" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2084595 /Source="Nicolas_upshifts" /id="U1808" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1055 /SigmaFactorBS="ttctgtctggtttttatcctttaccatataaaataaaaattg gTACAAAtcttgatgatatgtaTCATATAATAATTGAAAGGtttcttccatttgaaac c" /listShort="S877" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2084599..2084617 /Source="Nicolas_upshift_promotors" /id="U1808" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1055 /SigmaFactorBS="ttctgtctggtttttatcctttaccatataaaataaaaattg gTACAAAtcttgatgatatgtaTCATATAATAATTGAAAGGtttcttccatttgaaac c" /listShort="S877" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 2084635 /Source="Nicolas_upshifts" /id="D1211" /incds=0 /nref=8 /ntot=81 /MaxReadThrough="5.89234" /MaxDrop="4.38483" /score="6.57298987" /energy="-13.5" /TU="U1808" /idTUdmin="U1807" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2084676..2084695) /Source="Nicolas_upshift_promotors" /id="U1809" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.565434565434565" /psig="0.998001998001998" /xcortree=2781 /SigmaFactorBS="aaaatttaaggatatgttaatataaattcCCTTCCAAattcc agttactCGTAATATAGTTGTAATGTAacttttcaagctattcatacgacaaaaaagt g" /listShort="sigX, rsiX, aroC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2084680..2084787 /Source="Nicolas_S_feature" /locus_tag="new_2415264_2415371" /HighExp="S4, S8, S6, S7, C30, S3, LoTm, B60, BT, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.956" /TUlongSig="NA" /TUlongPSig="NA" /label="S877" upshifts complement(2084684) /Source="Nicolas_upshifts" /id="U1809" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.565434565434565" /psig="0.998001998001998" /xcortree=2781 /SigmaFactorBS="aaaatttaaggatatgttaatataaattcCCTTCCAAattcc agttactCGTAATATAGTTGTAATGTAacttttcaagctattcatacgacaaaaaagt g" /listShort="sigX, rsiX, aroC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2084708..2084715) /Source="Nicolas_upshift_promotors" /id="U1809" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.565434565434565" /psig="0.998001998001998" /xcortree=2781 /SigmaFactorBS="aaaatttaaggatatgttaatataaattcCCTTCCAAattcc agttactCGTAATATAGTTGTAATGTAacttttcaagctattcatacgacaaaaaagt g" /listShort="sigX, rsiX, aroC" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2084743 /Source="Nicolas_upshifts" /id="D1212" /incds=0 /nref=12 /ntot=64 /MaxReadThrough="2.08559" /MaxDrop="4.36303" /score="6.57298987" /energy="-13.5" /TU="NA" /idTUdmin="U1808" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" S_feature complement(2084772..2084830) /Source="Nicolas_S_feature" /locus_tag="new_2415356_2415414_c" /HighExp="Lbstat, BI, nit, S0, M40t90, Lbtran, M0t90, G135, Sw, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S878" downshifts complement(2084803) /Source="Nicolas_upshifts" /id="D1213" /incds=0 /nref=156 /ntot=252 /MaxReadThrough="2.62215" /MaxDrop="6.99198" /score="33.3049318" /energy="-13.5" /TU="NA" /idTUdmin="U1810" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(2084831..2086600) /gene="resE" /locus_tag="BSU_23110" /old_locus_tag="BSU23110" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11222591, 14996800, 16825793, 16885456, 17189364, 17322317, 17628154" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11222591, 14996800, 16825793, 16885456, 17189364, 17322317, 17628154; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase (ResD / ResE)" /protein_id="NP_390192.1" /db_xref="EnsemblGenomes-Gn:BSU23110" /db_xref="EnsemblGenomes-Tr:CAB14243" /db_xref="GOA:P35164" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR013767" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="PDB:4ZR7" /db_xref="SubtiList:BG10535" /db_xref="UniProtKB/Swiss-Prot:P35164" /translation="MKFWKSVVGKLWFTILSLVLIVLFILTVLLLEFIENYHVEEAEN DLTQLANKVAVILENHEDQALARSITWELADNLTSIAIIQDEKNHWYSPNDKNRLSSI TVEQIQHDKDLNKALKDHKKVSKRTGLSDTDTDNERLIVGVPYEKDGKKGMVFLSQSL LAVKDTTKHTTRYIFLAAGIAIVLTTFFAFFLSSRVTYPLRKMREGAQDLAKGKFDTK IPILTQDEIGELATAFNQMGRQLNFHINALNQEKEQLSNILSSMADGVITINIDGTIL VTNPPAERFLQAWYYEQNMNIKEGDNLPPEAKELFQNAVSTEKEQMIEMTLQGRSWVL LMSPLYAESHVRGAVAVLRDMTEERRLDKLREDFIANVSHELRTPISMLQGYSEAIVD DIASSEEDRKEIAQIIYDESLRMGRLVNDLLDLARMESGHTGLHYEKINVNEFLEKII RKFSGVAKEKNIALDHDISLTEEEFMFDEDKMEQVFTNLIDNALRHTSAGGSVSISVH SVKDGLKIDIKDSGSGIPEEDLPFIFERFYKADKARTRGRAGTGLGLAIVKNIVEAHN GSITVHSRIDKGTTFSFYIPTKR*" /label="resE CDS" gene complement(2084831..2086600) /gene="resE" /locus_tag="BSU_23110" /old_locus_tag="BSU23110" /label="resE gene" downshifts complement(2084887) /Source="Nicolas_upshifts" /id="D1214" /incds=0 /nref=5 /ntot=13 /MaxReadThrough="7.56028" /MaxDrop="3.58685" /score="33.3049318" /energy="-13.5" /TU="U1810,U1811,U1812" /idTUdmin="U1810" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" CDS complement(2086597..2087319) /gene="resD" /locus_tag="BSU_23120" /old_locus_tag="BSU23120" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10972836, 15028686, 15375128, 16825793, 16885456, 17322317, 17628154" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10972836, 15028686, 15375128, 16825793, 16885456, 17322317, 17628154; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator (ResD / ResE)" /protein_id="NP_390193.2" /db_xref="EnsemblGenomes-Gn:BSU23120" /db_xref="EnsemblGenomes-Tr:CAB14244" /db_xref="GOA:P35163" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10534" /db_xref="UniProtKB/Swiss-Prot:P35163" /translation="MDQTNETKILVVDDEARIRRLLRMYLERENYAIDEAENGDEAIA KGLEANYDLILLDLMMPGTDGIEVCRQIREKKATPIIMLTAKGEEANRVQGFEAGTDD YIVKPFSPREVVLRVKALLRRASQTSYFNANTPTKNVLVFSHLSIDHDAHRVTADGTE VSLTPKEYELLYFLAKTPDKVYDREKLLKEVWQYEFFGDLRTVDTHVKRLREKLNKVS PEAAKKIVTVWGVGYKFEVGAE*" /label="resD CDS" gene complement(2086597..2087319) /gene="resD" /locus_tag="BSU_23120" /old_locus_tag="BSU23120" /label="resD gene" S_feature complement(2087320..2087399) /Source="Nicolas_S_feature" /locus_tag="new_2417904_2417983_c" /HighExp="Lbstat, M0t90, ferm, M40t90, S2, S0, nit, M40t45, BI, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigEF" /TUshortPSig="0.998, 0.998, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S879" CDS complement(2087400..2088575) /gene="resC" /locus_tag="BSU_23130" /old_locus_tag="BSU23130" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10844653, 12682299, 15849754, 16850406, 19682263" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10844653, 12682299, 15849754, 16850406, 19682263; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor required for cytochrome c synthesis" /protein_id="NP_390194.2" /db_xref="EnsemblGenomes-Gn:BSU23130" /db_xref="EnsemblGenomes-Tr:CAB14245" /db_xref="GOA:P35162" /db_xref="InterPro:IPR002541" /db_xref="InterPro:IPR017562" /db_xref="SubtiList:BG10533" /db_xref="UniProtKB/Swiss-Prot:P35162" /translation="MAELSGNFLYAAFLVYLIAVPIFGGAIRGNKDKKGRPNRWANIG ITLSIVGFFCHLGYFITRWAASGHAPVSNMFEFTTAFGMMLVLAFIILYFLYRLPSLG LFTLSIALLLIAYASMFPTDISPLIPSLQSNWLYIHVTTAALGQAILAISFVAGVIFL LKHVDQTKPSKKTFWLEAIMFILVTTVAFIAITSAFRLAGYEAEFNWVDKSKEKSVMV YEMPALVGPHQGELLTEGRMEPLVDLPALFSGRKVNTVIWSFGAGLVLYGALRLIIRK RISALLHPLVKNVNLDLVDEVGYRAVSIGFPIFTLGALIFAMIWAQLAWTRFWGWDPK EVWALITFLFYAAYLHLRLSRGWHGEKSAWLAVIGFAIIMFNLIFVNLVLAGLHSYA* " /label="resC CDS" gene complement(2087400..2088575) /gene="resC" /locus_tag="BSU_23130" /old_locus_tag="BSU23130" /label="resC gene" CDS complement(2088595..2090223) /gene="resB" /locus_tag="BSU_23140" /old_locus_tag="BSU23140" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:9395519, 10844653, 12682299, 16825793, 19682263" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9395519, 10844653, 12682299, 16825793, 19682263; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor required for cytochrome c synthesis" /protein_id="NP_390195.1" /db_xref="EnsemblGenomes-Gn:BSU23140" /db_xref="EnsemblGenomes-Tr:CAB14246" /db_xref="GOA:P35161" /db_xref="InterPro:IPR007816" /db_xref="SubtiList:BG10532" /db_xref="UniProtKB/Swiss-Prot:P35161" /translation="MKQVKCECGHINPVGTVLCESCGRALQETQPPLADMRYDGSARR SQTYNKTIIDKIWNFFSSVKVGIWLIVITLAASAFGTIFPQEAYLPPGAQADTYYKEQ YGTFGQLYYLLGFHHLYGSWWYLLLIASIGISLVICSLDRVIPLYRALKNQGVRRSPA FLRRQRLFSETVTVLNGESKEKIVTLLKKKHYRIREKEGSILAEKGRFSRWGPYVNHI GLIIFLIGAMLRFVPGMYVDETLWVREGETAAIPGTDGKYYLKNNQFSVETYNSKTEK KVFADAIDRVGDGRVAKNFQTDAVLYKREGKIVYGEKPKLEKVTEEDIRVNQPLRFDS FSVYQVDYKENQLDQMVFQLIDKKTKKSFGSLKINLLDPDSVYDLGNGYKVEIASYLP DFYFNQDGEPSTKTKIPNNPAFVFNIITPDKPKGEKSFVAIQETIEGSGNNKYKLKFD HVETKNITGLTVRKDLTLWVLAVGGAIFMIGVIQGMYWQHRRIWLHSQDGAVMVAGHT NKNWFGLKKDLAFILADSGLTEPVDQKELIKTQK*" /label="resB CDS" gene complement(2088595..2090223) /gene="resB" /locus_tag="BSU_23140" /old_locus_tag="BSU23140" /label="resB gene" CDS complement(2090220..2090759) /gene="resA" /locus_tag="BSU_23150" /old_locus_tag="BSU23150" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:12637552, 12682299, 15667290, 16537372, 16825793, 16971393, 17189364, 18456809, 19682263, 22720735, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12637552, 12682299, 15667290, 16537372, 16825793, 16971393, 17189364, 18456809, 19682263, 22720735, 26735940; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="extracytoplasmic thioredoxin involved in cytochrome c maturation (lipoprotein)" /protein_id="NP_390196.2" /db_xref="EnsemblGenomes-Gn:BSU23150" /db_xref="EnsemblGenomes-Tr:CAB14247" /db_xref="GOA:P35160" /db_xref="InterPro:IPR000866" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR017937" /db_xref="InterPro:IPR023555" /db_xref="InterPro:IPR036249" /db_xref="PDB:1ST9" /db_xref="PDB:1SU9" /db_xref="PDB:2F9S" /db_xref="PDB:2H19" /db_xref="PDB:2H1A" /db_xref="PDB:2H1B" /db_xref="PDB:2H1D" /db_xref="PDB:2H1G" /db_xref="PDB:3C71" /db_xref="PDB:3C73" /db_xref="SubtiList:BG10531" /db_xref="UniProtKB/Swiss-Prot:P35160" /translation="MKKKRRLFIRTGILLVLICALGYTIYNAVFAGKESISEGSDAPN FVLEDTNGKRIELSDLKGKGVFLNFWGTWCEPCKKEFPYMANQYKHFKSQGVEIVAVN VGESKIAVHNFMKSYGVNFPVVLDTDRQVLDAYDVSPLPTTFLINPEGKVVKVVTGTM TESMIHDYMNLIKPGETSG*" /label="resA CDS" gene complement(2090220..2090759) /gene="resA" /locus_tag="BSU_23150" /old_locus_tag="BSU23150" /label="resA gene" S_feature complement(2090760..2090853) /Source="Nicolas_S_feature" /locus_tag="new_2421344_2421437_c" /HighExp="LBGtran, LBGstat, G180, Oxctl, H2O2, G150, M0t90, G135, Paraq, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigEF" /TUshortPSig="0.998, 0.998, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S880" CDS complement(2090854..2091588) /gene="rluB" /locus_tag="BSU_23160" /old_locus_tag="BSU23160" /EC_number="4.2.1.70" /function="16.13: Shape" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9888802, 24214967" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9888802, 24214967; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="23S rRNA pseudouridine 2633 (=2605 standard) pseudouridine synthase" /protein_id="NP_390197.2" /db_xref="EnsemblGenomes-Gn:BSU23160" /db_xref="EnsemblGenomes-Tr:CAB14248" /db_xref="GOA:P35159" /db_xref="InterPro:IPR000748" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR006145" /db_xref="InterPro:IPR018496" /db_xref="InterPro:IPR020103" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG10530" /db_xref="UniProtKB/Swiss-Prot:P35159" /translation="MERLQKVIAHAGVASRRKAEELIKEGKVKVNGKVVTELGVKVTG SDQIEVNGLKVEREEPVYFLLYKPRGVISAAQDDKGRKVVTDFFKNIPQRIYPIGRLD YDTSGLLLLTNDGEFANKLMHPKYEIDKTYVAKVKGIPPKELLRKLERGIRLEEGKTA PAKAKLLSLDKKKQTSIIQLTIHEGRNRQVRRMFEAIGHEVIKLKREEYAFLNLRGLH TGDARELTPHEVKRLRALADHGKNAF*" /label="rluB CDS" gene complement(2090854..2091588) /gene="rluB" /locus_tag="BSU_23160" /old_locus_tag="BSU23160" /label="rluB gene" promotor_-10 complement(2091597..2091616) /Source="Nicolas_upshift_promotors" /id="U1810" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.616383616383616" /psig="0.998001998001998" /xcortree=2676 /SigmaFactorBS="aaaacggcgttttttttagatttggcataggaatttgaaaaa gctTGTTTgttaaggttgaaaaAAGTAAGATAATACTTGAGGtgaaagacatggaaag a" /listShort="rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2091620) /Source="Nicolas_upshifts" /id="U1810" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.616383616383616" /psig="0.998001998001998" /xcortree=2676 /SigmaFactorBS="aaaacggcgttttttttagatttggcataggaatttgaaaaa gctTGTTTgttaaggttgaaaaAAGTAAGATAATACTTGAGGtgaaagacatggaaag a" /listShort="rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2091631..2091635) /Source="Nicolas_upshift_promotors" /id="U1810" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.616383616383616" /psig="0.998001998001998" /xcortree=2676 /SigmaFactorBS="aaaacggcgttttttttagatttggcataggaatttgaaaaa gctTGTTTgttaaggttgaaaaAAGTAAGATAATACTTGAGGtgaaagacatggaaag a" /listShort="rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2091680..2092216) /gene="spmB" /locus_tag="BSU_23170" /old_locus_tag="BSU23170" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7642500, 15849754, 16850406, 19189487" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7642500, 15849754, 16850406, 19189487; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore maturation protein" /protein_id="NP_390198.2" /db_xref="EnsemblGenomes-Gn:BSU23170" /db_xref="EnsemblGenomes-Tr:CAB14249" /db_xref="GOA:P35158" /db_xref="InterPro:IPR011642" /db_xref="SubtiList:BG10529" /db_xref="UniProtKB/Swiss-Prot:P35158" /translation="MEIINWLSLAMIPIIIAGILLYGTIKKVPTYESFVEGGKEGIEI AFSIIPYLVGMLVAITVFRSSGALDFIMDLLKPAFSAIGIPAEVVPLALIRPISGTAA LGMTTDLIAVYGPDSFIGRLASVMQGSTDTTLYVLTVYFGAVGIKKMGDALKVGLLAD LIGVVASIIIVTLLFGSA*" /label="spmB CDS" gene complement(2091680..2092216) /gene="spmB" /locus_tag="BSU_23170" /old_locus_tag="BSU23170" /label="spmB gene" promotor_-10 complement(2091685..2091704) /Source="Nicolas_upshift_promotors" /id="U1811" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.816183816183816" /psig="0.998001998001998" /xcortree=2645 /SigmaFactorBS="acttcttgcagatttaatcggcgTAGTTGCAtctatcatcat cgtTACGTTATTATTTGGGAGCGcctgaaaacggcgttttttttagatttggcatagg a" /listShort="rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2091689) /Source="Nicolas_upshifts" /id="U1811" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.816183816183816" /psig="0.998001998001998" /xcortree=2645 /SigmaFactorBS="acttcttgcagatttaatcggcgTAGTTGCAtctatcatcat cgtTACGTTATTATTTGGGAGCGcctgaaaacggcgttttttttagatttggcatagg a" /listShort="rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2091719..2091726) /Source="Nicolas_upshift_promotors" /id="U1811" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.816183816183816" /psig="0.998001998001998" /xcortree=2645 /SigmaFactorBS="acttcttgcagatttaatcggcgTAGTTGCAtctatcatcat cgtTACGTTATTATTTGGGAGCGcctgaaaacggcgttttttttagatttggcatagg a" /listShort="rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2092221..2092811) /gene="spmA" /locus_tag="BSU_23180" /old_locus_tag="BSU23180" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7642500, 15849754, 16850406, 19189487" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7642500, 15849754, 16850406, 19189487; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore maturation protein" /protein_id="NP_390199.1" /db_xref="EnsemblGenomes-Gn:BSU23180" /db_xref="EnsemblGenomes-Tr:CAB14250" /db_xref="GOA:P35157" /db_xref="InterPro:IPR011642" /db_xref="SubtiList:BG10528" /db_xref="UniProtKB/Swiss-Prot:P35157" /translation="MVNIIWVSLTVIGLVFAMCNGTLQDVNEAVFKGAKEAITISFGL MSVLVFWLGLMKIAEQSGLLDIFSRMCRPFISKLFPDIPPDHPAMGYILSNLMANFFG LGNAATPLGIKAMEQMKKLNGNRSEASRSMITFLAVNTSCITLIPTTVIAVRMAYSSK TPTDIVGPSILATLISGIGAIIIDRYFYYRRKKKGR*" /label="spmA CDS" gene complement(2092221..2092811) /gene="spmA" /locus_tag="BSU_23180" /old_locus_tag="BSU23180" /label="spmA gene" CDS complement(2092799..2093947) /gene="dacB" /locus_tag="BSU_23190" /old_locus_tag="BSU23190" /EC_number="3.4.16.4" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7642500, 8892816, 9864321, 10498740, 18266856, 19542328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7642500, 8892816, 9864321, 10498740, 18266856, 19542328; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 5*) (required for spore cortex)" /protein_id="NP_390200.1" /db_xref="EnsemblGenomes-Gn:BSU23190" /db_xref="EnsemblGenomes-Tr:CAB14251" /db_xref="GOA:P35150" /db_xref="InterPro:IPR001967" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR012907" /db_xref="InterPro:IPR018044" /db_xref="PDB:3MFD" /db_xref="SubtiList:BG10527" /db_xref="UniProtKB/Swiss-Prot:P35150" /translation="MRIFKKAVFVIMISFLIATVNVNTAHAAIDVSAKSAIIIDGASG RVLYAKDEHQKRRIASITKIMTAVLAIESGKMDQTVTVSANAVRTEGSAIYLTEGQKV KLKDLVYGLMLRSGNDAAVAIAEHVGGSLDGFVYMMNQKAEQLGMKNTRFQNPHGLDD HENHYSTAYDMAILTKYAMKLKDYQKISGTKIYKAETMESVWKNKNKLLTMLYPYSTG GKTGYTKLAKRTLVSTASKDGIDLIAVTINDPNDWDDHMKMFNYVFEHYQTYLIAKKG DIPKLKGTFYESKAFIKRDITYLLTEEEKENVKINTTLLKPKKAWEKDASKIPDIVGH MEIMFNDATIAKVPIYYENERHQKPKKQFFETFKSIFLNAAGGAKWSI*" /label="dacB CDS" gene complement(2092799..2093947) /gene="dacB" /locus_tag="BSU_23190" /old_locus_tag="BSU23190" /label="dacB gene" promotor_-10 complement(2093969..2093987) /Source="Nicolas_upshift_promotors" /id="U1812" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=990 /SigmaFactorBS="tatgtttgcttccagaaatataattgttaTTCATAactgatg gacatgcGCATAAACTTGTACAAACCaccacaaggacgtgagcaaacatgcgcatttt c" /listShort="dacB, spmA, spmB, rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2093976) /Source="Nicolas_upshifts" /id="U1812" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=990 /SigmaFactorBS="tatgtttgcttccagaaatataattgttaTTCATAactgatg gacatgcGCATAAACTTGTACAAACCaccacaaggacgtgagcaaacatgcgcatttt c" /listShort="dacB, spmA, spmB, rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2094002..2094007) /Source="Nicolas_upshift_promotors" /id="U1812" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=990 /SigmaFactorBS="tatgtttgcttccagaaatataattgttaTTCATAactgatg gacatgcGCATAAACTTGTACAAACCaccacaaggacgtgagcaaacatgcgcatttt c" /listShort="dacB, spmA, spmB, rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2094070..2094609) /gene="ypuI" /locus_tag="BSU_23200" /old_locus_tag="BSU23200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12065423" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390201.1" /db_xref="EnsemblGenomes-Gn:BSU23200" /db_xref="EnsemblGenomes-Tr:CAB14252" /db_xref="InterPro:IPR025013" /db_xref="SubtiList:BG10526" /db_xref="UniProtKB/Swiss-Prot:P35156" /translation="MKEAKCERQIHEGKIPNEMGHSIVRAQTQKTGEFLSMVVNTVND YLNQTTLESLQAELPIEKGYCCDVLSTLRRMAVFCEGGAEACRRLLMQEPFQEARAEK TLYNVYHQCIEEFFMPKKDTWCENSRASYTGVSAIEFYHAVPASLEQLLLPLSAAFLK MREELAHYEASGSSMAPIR*" /label="ypuI CDS" gene complement(2094070..2094609) /gene="ypuI" /locus_tag="BSU_23200" /old_locus_tag="BSU23200" /label="ypuI gene" downshifts complement(2094083) /Source="Nicolas_upshifts" /id="D1215" /incds=0 /nref=219 /ntot=260 /MaxReadThrough="1.63638" /MaxDrop="8.00748" /score="36.7302977" /energy="-12.2" /TU="NA" /idTUdmin="U1813" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2094618..2094635) /Source="Nicolas_upshift_promotors" /id="U1813" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.436563436563437" /psig="0.436563436563437" /xcortree=810 /SigmaFactorBS="tttaaccaaaccttcgaagatataaaatagaagtttaaTGAA TCgcgctttttcatcaTCATAAGATATAAGGAAGaagctatcatgaaagaagcaaaat g" /listShort="ypuI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2094633) /Source="Nicolas_upshifts" /id="U1813" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.436563436563437" /psig="0.436563436563437" /xcortree=810 /SigmaFactorBS="tttaaccaaaccttcgaagatataaaatagaagtttaaTGAA TCgcgctttttcatcaTCATAAGATATAAGGAAGaagctatcatgaaagaagcaaaat g" /listShort="ypuI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2094650..2094655) /Source="Nicolas_upshift_promotors" /id="U1813" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.436563436563437" /psig="0.436563436563437" /xcortree=810 /SigmaFactorBS="tttaaccaaaccttcgaagatataaaatagaagtttaaTGAA TCgcgctttttcatcaTCATAAGATATAAGGAAGaagctatcatgaaagaagcaaaat g" /listShort="ypuI" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2094664..2095257) /gene="spcB" /locus_tag="BSU_23210" /old_locus_tag="BSU23210" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12065423, 12100548, 12682299, 12897137, 16272394, 23541893, 24440393, 25951515, 26904953, 27435445, 28286005" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12065423, 12100548, 12682299, 12897137, 16272394, 23541893, 24440393, 25951515, 26904953, 27435445, 28286005; Product type f : factor" /codon_start=1 /transl_table=11 /product="chromosome condensation and segregation factor" /protein_id="NP_390202.1" /db_xref="EnsemblGenomes-Gn:BSU23210" /db_xref="EnsemblGenomes-Tr:CAB14253" /db_xref="GOA:P35155" /db_xref="InterPro:IPR005234" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10525" /db_xref="UniProtKB/Swiss-Prot:P35155" /translation="MGLDIVNWKAIVEALLYAAGDEGLTKKQLLTVLEIEEPELNTIM ADVADEYRGDTRGIELIEYADTYMLSTKKDFAPYLKKLIEVPSKGLSQASLEVLAIVS YKQPITRAEIEEIRGVKSERILHSLVAKALLCEVGRADGPGRAILYGTTPTFLEQFGL KTLDELPPLPENAEEDVLQEEADLFFENFNQTFEDIK*" /label="spcB CDS" gene complement(2094664..2095257) /gene="spcB" /locus_tag="BSU_23210" /old_locus_tag="BSU23210" /label="spcB gene" CDS complement(2095247..2096002) /gene="scpA" /locus_tag="BSU_23220" /old_locus_tag="BSU23220" /function="16.13: Shape" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12065423, 12100548, 12682299, 12897137, 16272394, 23541893, 24440393, 25951515, 26904953, 28286005" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12065423, 12100548, 12682299, 12897137, 16272394, 23541893, 24440393, 25951515, 26904953, 28286005; Product type f: factor" /codon_start=1 /transl_table=11 /product="chromosome condensation and partitioning factor" /protein_id="NP_390203.1" /db_xref="EnsemblGenomes-Gn:BSU23220" /db_xref="EnsemblGenomes-Tr:CAB14254" /db_xref="GOA:P35154" /db_xref="InterPro:IPR003768" /db_xref="PDB:3ZGX" /db_xref="PDB:5H66" /db_xref="PDB:5H67" /db_xref="PDB:5XG3" /db_xref="SubtiList:BG10524" /db_xref="UniProtKB/Swiss-Prot:P35154" /translation="MEEYQVKIDTFEGPLDLLLHLINRLEIDIYDIPVAKITEQYLLY VHTMRVLELDIASEYLVMAATLLSIKSRMLLPKQEEELFEDELLEEEDPREELIEKLI EYRKYKDAAKDLKEREEERQKSFTKPPSDLSEYAKEVKQSEQKLSVTVYDMIGAFQKV LKRKKINRPMETTITRQDIPIEARMNEIVHSLKSRGTRINFMDLFPYEQKEHLVVTFL AVLELMKNQLVLIEQEHNFSDIYITGSESIHGA*" /label="scpA CDS" gene complement(2095247..2096002) /gene="scpA" /locus_tag="BSU_23220" /old_locus_tag="BSU23220" /label="scpA gene" promotor_-35 2095846..2095855 /Source="Nicolas_upshift_promotors" /id="U1814" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1387 /SigmaFactorBS="cataaccaaatactcgctggcaatgtcgaGCTCAAGCACgcg catcgtatgTACATATAATAAATATTGTTcagtgatcttcgccacaggtatatcatat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2095868..2095887 /Source="Nicolas_upshift_promotors" /id="U1814" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1387 /SigmaFactorBS="cataaccaaatactcgctggcaatgtcgaGCTCAAGCACgcg catcgtatgTACATATAATAAATATTGTTcagtgatcttcgccacaggtatatcatat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2095877 /Source="Nicolas_upshifts" /id="U1814" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1387 /SigmaFactorBS="cataaccaaatactcgctggcaatgtcgaGCTCAAGCACgcg catcgtatgTACATATAATAAATATTGTTcagtgatcttcgccacaggtatatcatat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2096048..2096067) /Source="Nicolas_upshift_promotors" /id="U1815" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.862137862137862" /psig=1 /xcortree=2560 /SigmaFactorBS="ctgtacaaactccttcaaaacaggatatgaaatagTATTGGA CgagagctttttggTGGCTTATACTATAGGGTAGccagtttttccggcaatgagagtg a" /listShort="scpA, spcB, ypuI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2096063) /Source="Nicolas_upshifts" /id="U1815" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.862137862137862" /psig=1 /xcortree=2560 /SigmaFactorBS="ctgtacaaactccttcaaaacaggatatgaaatagTATTGGA CgagagctttttggTGGCTTATACTATAGGGTAGccagtttttccggcaatgagagtg a" /listShort="scpA, spcB, ypuI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2096081..2096088) /Source="Nicolas_upshift_promotors" /id="U1815" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.862137862137862" /psig=1 /xcortree=2560 /SigmaFactorBS="ctgtacaaactccttcaaaacaggatatgaaatagTATTGGA CgagagctttttggTGGCTTATACTATAGGGTAGccagtttttccggcaatgagagtg a" /listShort="scpA, spcB, ypuI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2096228..2096235 /Source="Nicolas_upshift_promotors" /id="U1816" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2166 /SigmaFactorBS="tttcctttctaagaagcactagaggccgggcgttcttTTTTC CTTttatcccttcTATGGTACACTAAAAGCACAttaaaggaggaagcaccttgtatcc g" /listShort="ypuF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2096246..2096265 /Source="Nicolas_upshift_promotors" /id="U1816" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2166 /SigmaFactorBS="tttcctttctaagaagcactagaggccgggcgttcttTTTTC CTTttatcccttcTATGGTACACTAAAAGCACAttaaaggaggaagcaccttgtatcc g" /listShort="ypuF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2096251 /Source="Nicolas_upshifts" /id="U1816" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2166 /SigmaFactorBS="tttcctttctaagaagcactagaggccgggcgttcttTTTTC CTTttatcccttcTATGGTACACTAAAAGCACAttaaaggaggaagcaccttgtatcc g" /listShort="ypuF" /GFF_Attribute="listLong" /label="upshifts" CDS 2096283..2096807 /gene="ypuF" /locus_tag="BSU_23230" /old_locus_tag="BSU23230" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390204.1" /db_xref="EnsemblGenomes-Gn:BSU23230" /db_xref="EnsemblGenomes-Tr:CAB14255" /db_xref="InterPro:IPR005500" /db_xref="InterPro:IPR023203" /db_xref="SubtiList:BG10523" /db_xref="UniProtKB/Swiss-Prot:P17617" /translation="MYPKAYIDYLVEFHATRDYFECHEILEEYWKEDPPKKRKRYWVG FIQLAVALYHHRRQNTAGAKRLMANSIRILQAEHRAVEDLGLDHGRLLELMQSVYEQI ETVSAYKSIILPIKDEKLEEACRIECRKKKYTWGQPSALSNIFLIDKHRLRDRTDVIR EREKEIERRKKSRD*" /label="ypuF CDS" gene 2096283..2096807 /gene="ypuF" /locus_tag="BSU_23230" /old_locus_tag="BSU23230" /label="ypuF gene" CDS complement(2096821..2097195) /gene="ypzK" /locus_tag="BSU_23240" /old_locus_tag="BSU23240" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15466513, 25349719; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative riboflavin synthesis-related N-acetyltransferase" /protein_id="NP_390205.1" /db_xref="EnsemblGenomes-Gn:BSU23240" /db_xref="EnsemblGenomes-Tr:CAB14256" /db_xref="GOA:P17622" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG10522" /db_xref="UniProtKB/Swiss-Prot:P17622" /translation="MLIRYKKSFEKIAMGLLSFMPNEKDLKQLQQTIKDYETDTDRQL FLWKEDEDIVGAIGVEKKDSEVEIRHISVNPSHRHQGIGKQMMDALKHLFKTQVLVPN ELTQSFFERCQGQQDQDISYNN*" /label="ypzK CDS" gene complement(2096821..2097195) /gene="ypzK" /locus_tag="BSU_23240" /old_locus_tag="BSU23240" /label="ypzK gene" downshifts complement(2096837) /Source="Nicolas_upshifts" /id="D1216" /incds=0 /nref=264 /ntot=275 /MaxReadThrough="1.34496" /MaxDrop="8.09525" /score="39.5464967" /energy="-14.3" /TU="NA" /idTUdmin="U1817" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2097257..2097276) /Source="Nicolas_upshift_promotors" /id="U1817" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.601398601398601" /psig="0.993006993006993" /xcortree=420 /SigmaFactorBS="tttaaaccgctcatttgaataatttgctgaaaacAGTTTAAA aatatggcgaaAATGATATAATGTGAGAAAAcggatcacctattcgtatccgttaata g" /listShort="ypzK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2097269) /Source="Nicolas_upshifts" /id="U1817" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.601398601398601" /psig="0.993006993006993" /xcortree=420 /SigmaFactorBS="tttaaaccgctcatttgaataatttgctgaaaacAGTTTAAA aatatggcgaaAATGATATAATGTGAGAAAAcggatcacctattcgtatccgttaata g" /listShort="ypzK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2097288..2097295) /Source="Nicolas_upshift_promotors" /id="U1817" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.601398601398601" /psig="0.993006993006993" /xcortree=420 /SigmaFactorBS="tttaaaccgctcatttgaataatttgctgaaaacAGTTTAAA aatatggcgaaAATGATATAATGTGAGAAAAcggatcacctattcgtatccgttaata g" /listShort="ypzK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2097308..2097772) /gene="ribH" /locus_tag="BSU_23250" /old_locus_tag="BSU23250" /EC_number="2.5.1.78" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3100522, 7473709, 10881048, 12456892, 24442413" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3100522, 7473709, 10881048, 12456892, 24442413; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="6,7-dimethyl-8-ribityllumazine synthase, beta subunit" /protein_id="NP_390206.1" /db_xref="EnsemblGenomes-Gn:BSU23250" /db_xref="EnsemblGenomes-Tr:CAB14257" /db_xref="GOA:P11998" /db_xref="InterPro:IPR002180" /db_xref="InterPro:IPR034964" /db_xref="InterPro:IPR036467" /db_xref="PDB:1RVV" /db_xref="PDB:1ZIS" /db_xref="SubtiList:BG10521" /db_xref="UniProtKB/Swiss-Prot:P11998" /translation="MNIIQGNLVGTGLKIGIVVGRFNDFITSKLLSGAEDALLRHGVD TNDIDVAWVPGAFEIPFAAKKMAETKKYDAIITLGTVIRGATTHYDYVCNEAAKGIAQ AANTTGVPVIFGIVTTENIEQAIERAGTKAGNKGVDCAVSAIEMANLNRSFE*" /label="ribH CDS" gene complement(2097308..2097772) /gene="ribH" /locus_tag="BSU_23250" /old_locus_tag="BSU23250" /label="ribH gene" promotor_-35 2097643..2097647 /Source="Nicolas_upshift_promotors" /id="U1818" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.974025974025974" /psig="0.000999000999001" /xcortree=35 /SigmaFactorBS="atgcgcctggaacccaagccacatcaatgtcatttgtgtCTA CGccatgtctgagcaGCGCAtcttctgctccgctcagcagcttgctcgtaataaaatc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2097661..2097665 /Source="Nicolas_upshift_promotors" /id="U1818" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.974025974025974" /psig="0.000999000999001" /xcortree=35 /SigmaFactorBS="atgcgcctggaacccaagccacatcaatgtcatttgtgtCTA CGccatgtctgagcaGCGCAtcttctgctccgctcagcagcttgctcgtaataaaatc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2097664 /Source="Nicolas_upshifts" /id="U1818" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.974025974025974" /psig="0.000999000999001" /xcortree=35 /SigmaFactorBS="atgcgcctggaacccaagccacatcaatgtcatttgtgtCTA CGccatgtctgagcaGCGCAtcttctgctccgctcagcagcttgctcgtaataaaatc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2097805..2099001) /gene="ribBA" /locus_tag="BSU_23260" /old_locus_tag="BSU23260" /EC_number="3.5.4.25" /EC_number="4.1.99.12" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9297088, 9515916, 12456892, 19583770, 24442413" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9297088, 9515916, 12456892, 19583770, 24442413; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fused 3,4-dihydroxy-2-butanone 4-phosphate synthase and GTP cyclohydrolase II" /protein_id="NP_390207.1" /db_xref="EnsemblGenomes-Gn:BSU23260" /db_xref="EnsemblGenomes-Tr:CAB14258" /db_xref="GOA:P17620" /db_xref="InterPro:IPR000422" /db_xref="InterPro:IPR000926" /db_xref="InterPro:IPR016299" /db_xref="InterPro:IPR017945" /db_xref="InterPro:IPR032677" /db_xref="InterPro:IPR036144" /db_xref="SubtiList:BG10520" /db_xref="UniProtKB/Swiss-Prot:P17620" /translation="MFHPIEEALDALKKGEVIIVVDDEDRENEGDFVALAEHATPEVI NFMATHGRGLICTPLSEEIADRLDLHPMVEHNTDSHHTAFTVSIDHRETKTGISAQER SFTVQALLDSKSVPSDFQRPGHIFPLIAKKGGVLKRAGHTEAAVDLAEACGSPGAGVI CEIMNEDGTMARVPELIEIAKKHQLKMITIKDLIQYRYNLTTLVEREVDITLPTDFGT FKVYGYTNEVDGKEHVAFVMGDVPFGEEPVLVRVHSECLTGDVFGSHRCDCGPQLHAA LNQIAAEGRGVLLYLRQEGRGIGLINKLKAYKLQEQGYDTVEANEALGFLPDLRNYGI GAQILRDLGVRNMKLLTNNPRKIAGLEGYGLSISERVPLQMEAKEHNKKYLQTKMNKL GHLLHF*" /label="ribBA CDS" gene complement(2097805..2099001) /gene="ribBA" /locus_tag="BSU_23260" /old_locus_tag="BSU23260" /label="ribBA gene" CDS complement(2099016..2099663) /gene="ribE" /locus_tag="BSU_23270" /old_locus_tag="BSU23270" /EC_number="2.5.1.9" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2106516, 12456892" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2106516, 12456892; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="riboflavin synthase (alpha subunit)" /protein_id="NP_390208.1" /db_xref="EnsemblGenomes-Gn:BSU23270" /db_xref="EnsemblGenomes-Tr:CAB14259" /db_xref="GOA:P16440" /db_xref="InterPro:IPR001783" /db_xref="InterPro:IPR017938" /db_xref="InterPro:IPR023366" /db_xref="InterPro:IPR026017" /db_xref="SubtiList:BG10519" /db_xref="UniProtKB/Swiss-Prot:P16440" /translation="MFTGIIEETGTIESMKKAGHAMALTIKCSKILEDVHLGDSIAVN GICLTVTDFTKNQFTVDVMPETVKATSLNDLTKGSKVNLERAMAANGRFGGHFVSGHV DGTAEITRIEEKSNAVYYDLKMDPSLTKTLVLKGSITVDGVSLTIFGLTEDTVTISLI PHTISETIFSEKTIGSKVNIECDMIGKYMYRFLHKANENKTQQTITKAFLSENGF*" /label="ribE CDS" gene complement(2099016..2099663) /gene="ribE" /locus_tag="BSU_23270" /old_locus_tag="BSU23270" /label="ribE gene" CDS complement(2099674..2100759) /gene="ribD" /locus_tag="BSU_23280" /old_locus_tag="BSU23280" /EC_number="1.1.1.193" /EC_number="3.5.4.26" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9068650, 12456892, 17765262, 18986985, 23385458" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9068650, 12456892, 17765262, 18986985, 23385458; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fused diaminohydroxyphosphoribosylaminopyrimidine deaminase; 5-amino-6-(5-phosphoribosylamino) uracil reductase" /protein_id="NP_390209.1" /db_xref="EnsemblGenomes-Gn:BSU23280" /db_xref="EnsemblGenomes-Tr:CAB14260" /db_xref="GOA:P17618" /db_xref="InterPro:IPR002125" /db_xref="InterPro:IPR002734" /db_xref="InterPro:IPR004794" /db_xref="InterPro:IPR011549" /db_xref="InterPro:IPR016192" /db_xref="InterPro:IPR016193" /db_xref="InterPro:IPR024072" /db_xref="PDB:2B3Z" /db_xref="PDB:2D5N" /db_xref="PDB:3EX8" /db_xref="PDB:4G3M" /db_xref="SubtiList:BG10518" /db_xref="UniProtKB/Swiss-Prot:P17618" /translation="MEEYYMKLALDLAKQGEGQTESNPLVGAVVVKDGQIVGMGAHLK YGEAHAEVHAIHMAGAHAEGADIYVTLEPCSHYGKTPPCAELIINSGIKRVFVAMRDP NPLVAGRGISMMKEAGIEVREGILADQAERLNEKFLHFMRTGLPYVTLKAAASLDGKI ATSTGDSKWITSEAARQDAQQYRKTHQSILVGVGTVKADNPSLTCRLPNVTKQPVRVI LDTVLSIPEDAKVICDQIAPTWIFTTARADEEKKKRLSAFGVNIFTLETERIQIPDVL KILAEEGIMSVYVEGGSAVHGSFVKEGCFQEIIFYFAPKLIGGTHAPSLISGEGFQSM KDVPLLQFTDITQIGRDIKLTAKPTKE*" /label="ribD CDS" gene complement(2099674..2100759) /gene="ribD" /locus_tag="BSU_23280" /old_locus_tag="BSU23280" /label="ribD gene" S_feature complement(2100760..2100888) /Source="Nicolas_S_feature" /locus_tag="new_2431344_2431472_c" /HighExp="T0.30H, B60, T1.30H, T2.0H, MG-0.2, T1.0H, S1, T0.0H, LPhT, T-0.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S881" misc_RNA complement(2100889..2101033) /gene="fswA" /locus_tag="BSU_misc_RNA_36" /product="flavin riboswitch" /experiment="publication(s) with functional evidences, PMID:12456892, 15808508, 17693491, 17997835" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12456892, 15808508, 17693491, 17997835; Product type n: RNA" /label="fswA RNA" gene complement(2100889..2101033) /gene="fswA" /locus_tag="BSU_misc_RNA_36" /label="fswA gene" promotor_-10 complement(2101050..2101069) /Source="Nicolas_upshift_promotors" /id="U1819" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.437562437562438" /psig="0.996003996003996" /xcortree=606 /SigmaFactorBS="tttgtttttctcaaattgtaagtttatttCATTGCGTacttt aaaaaggatCGCTATAATAACCAATAAGGacaaatgaataaagattgtatccttcggg g" /listShort="NA, S881, ribD, ribE, ribAB, ribH, ypzK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2101060) /Source="Nicolas_upshifts" /id="U1819" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.437562437562438" /psig="0.996003996003996" /xcortree=606 /SigmaFactorBS="tttgtttttctcaaattgtaagtttatttCATTGCGTacttt aaaaaggatCGCTATAATAACCAATAAGGacaaatgaataaagattgtatccttcggg g" /listShort="NA, S881, ribD, ribE, ribAB, ribH, ypzK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2101084..2101091) /Source="Nicolas_upshift_promotors" /id="U1819" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.437562437562438" /psig="0.996003996003996" /xcortree=606 /SigmaFactorBS="tttgtttttctcaaattgtaagtttatttCATTGCGTacttt aaaaaggatCGCTATAATAACCAATAAGGacaaatgaataaagattgtatccttcggg g" /listShort="NA, S881, ribD, ribE, ribAB, ribH, ypzK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2101153..2101497) /gene="ypuD" /locus_tag="BSU_23300" /old_locus_tag="BSU23300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390211.1" /db_xref="EnsemblGenomes-Gn:BSU23300" /db_xref="EnsemblGenomes-Tr:CAB14262" /db_xref="SubtiList:BG10516" /db_xref="UniProtKB/Swiss-Prot:P17616" /translation="MGRIKTKITILLVLLLLLAGGYMYINDIELKDVPTAIGQTLSSE EEEYTIQEYKVTKIDGSEYHGVAENGTKIIFNGKKLNQDLSDIKEGDKIKAYFSKSKR IDGLIKVAKVND*" /label="ypuD CDS" gene complement(2101153..2101497) /gene="ypuD" /locus_tag="BSU_23300" /old_locus_tag="BSU23300" /label="ypuD gene" downshifts complement(2101168) /Source="Nicolas_upshifts" /id="D1217" /incds=0 /nref=78 /ntot=221 /MaxReadThrough="1.58771" /MaxDrop="5.14851" /score="20.5522057" /energy="-14.7" /TU="NA" /idTUdmin="U1820" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2101529..2101547) /Source="Nicolas_upshift_promotors" /id="U1820" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=749 /SigmaFactorBS="tgcatcgttatattaataatttacgagaatttacGGTTTTTt attcatgaaaaaaAGGAATAACTCATATGAATgaatagattcatattggctggaggtt t" /listShort="ypuD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2101542) /Source="Nicolas_upshifts" /id="U1820" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=749 /SigmaFactorBS="tgcatcgttatattaataatttacgagaatttacGGTTTTTt attcatgaaaaaaAGGAATAACTCATATGAATgaatagattcatattggctggaggtt t" /listShort="ypuD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2101556..2101561 /Source="Nicolas_upshift_promotors" /id="U1821" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1077 /SigmaFactorBS="tatgaatctattcattcatatgagttattcctttttttcaTG AATAaaaaaccgtaaattcTCGTAAATTATTAATATAAcgatgcataacgggaatatg t" /listShort="S882" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2101562..2101568) /Source="Nicolas_upshift_promotors" /id="U1820" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=749 /SigmaFactorBS="tgcatcgttatattaataatttacgagaatttacGGTTTTTt attcatgaaaaaaAGGAATAACTCATATGAATgaatagattcatattggctggaggtt t" /listShort="ypuD" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2101576..2102498 /Source="Nicolas_S_feature" /locus_tag="new_2432160_2433082" /HighExp="S5, S4, S6, S8, S7, C30, S3, C90, BT, BC" /AntisenseName="sipS" /AntisenseCor="-0.46666993867379197" /AntisenseRegPval="-15.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S882" upshifts 2101576 /Source="Nicolas_upshifts" /id="U1821" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1077 /SigmaFactorBS="tatgaatctattcattcatatgagttattcctttttttcaTG AATAaaaaaccgtaaattcTCGTAAATTATTAATATAAcgatgcataacgggaatatg t" /listShort="S882" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2101577..2101595 /Source="Nicolas_upshift_promotors" /id="U1821" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1077 /SigmaFactorBS="tatgaatctattcattcatatgagttattcctttttttcaTG AATAaaaaaccgtaaattcTCGTAAATTATTAATATAAcgatgcataacgggaatatg t" /listShort="S882" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2101583..2101598) /Source="Nicolas_upshift_promotors" /id="U1822" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1641 /SigmaFactorBS="atagaaaagaaatttttgcagaaatgTGAAACATATtcccgt tatgcaTCGTTATATTAATAATttacgagaatttacggttttttattcatgaaaaaaa g" /listShort="ypuD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2101586) /Source="Nicolas_upshifts" /id="U1822" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1641 /SigmaFactorBS="atagaaaagaaatttttgcagaaatgTGAAACATATtcccgt tatgcaTCGTTATATTAATAATttacgagaatttacggttttttattcatgaaaaaaa g" /listShort="ypuD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2101588..2101654) /Source="Nicolas_S_feature" /locus_tag="new_2432172_2432238_c" /HighExp="Etha, T1.30H, M9-stat, T0.30H, M40t90, T2.30H, MG-0.2, MG 15, HiTm, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigI, SigA" /TUshortPSig="1, 0.994" /TUlongSig="SigA" /TUlongPSig="0.97" /label="S883" promotor_-35 complement(2101611..2101620) /Source="Nicolas_upshift_promotors" /id="U1822" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1641 /SigmaFactorBS="atagaaaagaaatttttgcagaaatgTGAAACATATtcccgt tatgcaTCGTTATATTAATAATttacgagaatttacggttttttattcatgaaaaaaa g" /listShort="ypuD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2101649..2101657) /Source="Nicolas_upshift_promotors" /id="U1823" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp=1 /psig=1 /xcortree=1769 /SigmaFactorBS="ttggggctgctttttttatatcttttttacggtcaTCCCCTA AAaacagaacataaaTTCGTATATctatagaaaagaaatttttgcagaaatgtgaaac a" /listShort="S883, ypuD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2101654) /Source="Nicolas_upshifts" /id="U1823" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp=1 /psig=1 /xcortree=1769 /SigmaFactorBS="ttggggctgctttttttatatcttttttacggtcaTCCCCTA AAaacagaacataaaTTCGTATATctatagaaaagaaatttttgcagaaatgtgaaac a" /listShort="S883, ypuD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2101671..2101679) /Source="Nicolas_upshift_promotors" /id="U1823" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp=1 /psig=1 /xcortree=1769 /SigmaFactorBS="ttggggctgctttttttatatcttttttacggtcaTCCCCTA AAaacagaacataaaTTCGTATATctatagaaaagaaatttttgcagaaatgtgaaac a" /listShort="S883, ypuD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2101732..2102286) /gene="sipS" /locus_tag="BSU_23310" /old_locus_tag="BSU23310" /EC_number="3.4.21.89" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:8282190, 9325333, 9694797, 9823656, 10198007, 10336490, 10982814, 11004175, 11309398, 15502345" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8282190, 9325333, 9694797, 9823656, 10198007, 10336490, 10982814, 11004175, 11309398, 15502345; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="type I signal peptidase" /protein_id="NP_390212.1" /db_xref="EnsemblGenomes-Gn:BSU23310" /db_xref="EnsemblGenomes-Tr:CAB14263" /db_xref="GOA:P28628" /db_xref="InterPro:IPR000223" /db_xref="InterPro:IPR015927" /db_xref="InterPro:IPR019756" /db_xref="InterPro:IPR019757" /db_xref="InterPro:IPR019758" /db_xref="InterPro:IPR036286" /db_xref="SubtiList:BG10515" /db_xref="UniProtKB/Swiss-Prot:P28628" /translation="MKSENVSKKKSILEWAKAIVIAVVLALLIRNFIFAPYVVDGDSM YPTLHNRERVFVNMTVKYIGEFDRGDIVVLNGDDVHYVKRIIGLPGDTVEMKNDQLYI NGKKVDEPYLAANKKRAKQDGFDHLTDDFGPVKVPDNKYFVMGDNRRNSMDSRNGLGL FTKKQIAGTSKFVFYPFNEMRKTN*" /label="sipS CDS" gene complement(2101732..2102286) /gene="sipS" /locus_tag="BSU_23310" /old_locus_tag="BSU23310" /label="sipS gene" downshifts complement(2101742) /Source="Nicolas_upshifts" /id="D1218" /incds=0 /nref=195 /ntot=252 /MaxReadThrough="3.6233" /MaxDrop="7.24702" /score="30.4586783" /energy="-10.9" /TU="U1824" /idTUdmin="U1825" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2102312..2102331) /Source="Nicolas_upshift_promotors" /id="U1824" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.901098901098901" /psig="0.994005994005994" /xcortree=3155 /SigmaFactorBS="atgaagattaacagtttgtaaaatcacttcaatggtcctaaT GGGATTttttttcgattCGTGATAACATAAATTGAAGaccgttgtttattggaggaaa t" /listShort="sipS, S883, ypuD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2102330) /Source="Nicolas_upshifts" /id="U1824" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.901098901098901" /psig="0.994005994005994" /xcortree=3155 /SigmaFactorBS="atgaagattaacagtttgtaaaatcacttcaatggtcctaaT GGGATTttttttcgattCGTGATAACATAAATTGAAGaccgttgtttattggaggaaa t" /listShort="sipS, S883, ypuD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2102332..2102731) /Source="Nicolas_S_feature" /locus_tag="new_2432916_2433315_c" /HighExp="T4.0H, T2.30H, T5.0H, T3.0H, T2.0H, T3.30H, M9-stat, C90, BC, T1.30H" /AntisenseName="ypzC" /AntisenseCor="-0.215992681600812" /AntisenseRegPval="-3.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.97" /TUlongSig="NA" /TUlongPSig="NA" /label="S884" promotor_-35 complement(2102343..2102349) /Source="Nicolas_upshift_promotors" /id="U1824" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.901098901098901" /psig="0.994005994005994" /xcortree=3155 /SigmaFactorBS="atgaagattaacagtttgtaaaatcacttcaatggtcctaaT GGGATTttttttcgattCGTGATAACATAAATTGAAGaccgttgtttattggaggaaa t" /listShort="sipS, S883, ypuD" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2102553..2102789 /gene="ypzC" /locus_tag="BSU_23320" /old_locus_tag="BSU23320" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_390213.1" /db_xref="EnsemblGenomes-Gn:BSU23320" /db_xref="EnsemblGenomes-Tr:CAB14264" /db_xref="SubtiList:BG13765" /db_xref="UniProtKB/Swiss-Prot:O32012" /translation="MFIYCIPLISQSMIPMALDKTINVMKVTGMFAATYFTGDNRTPF FAFIICLKSFKLENMDQPPKNKSNIFPAVEDSLL*" /label="ypzC CDS" gene 2102553..2102789 /gene="ypzC" /locus_tag="BSU_23320" /old_locus_tag="BSU23320" /label="ypzC gene" CDS complement(2102732..2102938) /gene="ypzJ" /locus_tag="BSU_23328" /old_locus_tag="BSU23328" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097757.1" /db_xref="EnsemblGenomes-Gn:BSU23328" /db_xref="EnsemblGenomes-Tr:CAX52656" /db_xref="InterPro:IPR018652" /db_xref="UniProtKB/Swiss-Prot:C0H447" /translation="MNNKGCIKCGSTEAGQKEIATTGTGLSKLFDVQHNRFLVVYCKN CGYSEFYNKESSTAGNILDLFFGG*" /label="ypzJ CDS" gene complement(2102732..2102938) /gene="ypzJ" /locus_tag="BSU_23328" /old_locus_tag="BSU23328" /label="ypzJ gene" misc_feature complement(2102971..2102990) /Source="Nicolas_upshift_promotors" /id="U1825" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.440559440559441" /psig="0.97002997002997" /xcortree=2780 /SigmaFactorBS="caattagtatgtaatcaaaattaagtaaactttaaagtagta cgggtcattgggattgatattTTGTAGTAAAATAAATCAAAcaaacgtgatgtaatga a" /listShort="ypzJ, S884, sipS" /listLong="S883, ypuD" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2102993) /Source="Nicolas_upshifts" /id="U1825" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.440559440559441" /psig="0.97002997002997" /xcortree=2780 /SigmaFactorBS="caattagtatgtaatcaaaattaagtaaactttaaagtagta cgggtcattgggattgatattTTGTAGTAAAATAAATCAAAcaaacgtgatgtaatga a" /listShort="ypzJ, S884, sipS" /listLong="S883, ypuD" /label="upshifts" CDS complement(2103047..2103301) /gene="ypuC" /locus_tag="BSU_23329" /old_locus_tag="BSU23329" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="fragment of hypothetical protein" /db_xref="PSEUDO:CAX52657.1" /translation="MSFLVFVLIFLFVILTRRVCKLLHFFVYYRFIPHRAEPCVLYEQ YPSDVAAGYAFGGVWLSLNVLVMELFRFSRRFTKLRNEPN*" /label="ypuC CDS" gene complement(2103047..2103301) /gene="ypuC" /locus_tag="BSU_23329" /old_locus_tag="BSU23329" /pseudo /label="ypuC gene" promotor_-35 2103181..2103190 /Source="Nicolas_upshift_promotors" /id="U1826" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1336 /SigmaFactorBS="taacccgcagcaacatcactcggatactgctcataaaGTACA CACGGctcagcccgatgaGGAATAAAACGATAATAAACaaaaaaatgcaacagtttgc a" /listShort="S885" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2103192..2103581) /gene="ypuC" /locus_tag="BSU_23330" /old_locus_tag="BSU23330" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 15849754, 16850406" /pseudo /codon_start=1 /transl_table=11 /product="fragment of hypothetical protein" /db_xref="SubtiList:BG10514" /translation="MSYWIGYRLGPAAIQKAFASRGVLLAVIVLTFFWTVFRGQDRKI ELSFLFFLVIGGELYEEGIRRLFHSLHPVHAPLESHVLYPFPSEQTLTAFVIFGFCAY LFVRHSHKTRLQTVAFFCLLSFYSSSG*" /label="ypuC CDS" gene complement(2103192..2103581) /gene="ypuC" /locus_tag="BSU_23330" /old_locus_tag="BSU23330" /pseudo /label="ypuC gene" S_feature 2103204..2104275 /Source="Nicolas_S_feature" /locus_tag="new_2433788_2434859" /HighExp="S6, S8, S7, BT, S5, B36, S4, Pyr, G/S, C30" /AntisenseName="ypuC" /AntisenseCor="0.37168085148262697" /AntisenseRegPval="-9.5" /CDS_PredictionProba="0.69113899999999995" /TUshortSig="SigK" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S885" promotor_-10 2103204..2103223 /Source="Nicolas_upshift_promotors" /id="U1826" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1336 /SigmaFactorBS="taacccgcagcaacatcactcggatactgctcataaaGTACA CACGGctcagcccgatgaGGAATAAAACGATAATAAACaaaaaaatgcaacagtttgc a" /listShort="S885" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2103204 /Source="Nicolas_upshifts" /id="U1826" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1336 /SigmaFactorBS="taacccgcagcaacatcactcggatactgctcataaaGTACA CACGGctcagcccgatgaGGAATAAAACGATAATAAACaaaaaaatgcaacagtttgc a" /listShort="S885" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2103559..2103762) /gene="ypuB" /locus_tag="BSU_23340" /old_locus_tag="BSU23340" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_390215.1" /db_xref="EnsemblGenomes-Gn:BSU23340" /db_xref="EnsemblGenomes-Tr:CAB14266" /db_xref="SubtiList:BG10513" /db_xref="UniProtKB/Swiss-Prot:P35151" /translation="MQVLTGLLEQYGYAVLFIVLMLELLALLGPGEFAGVLVFQEKLN WVLSMLAAGLGSCGSEHVVLDRV*" /label="ypuB CDS" gene complement(2103559..2103762) /gene="ypuB" /locus_tag="BSU_23340" /old_locus_tag="BSU23340" /label="ypuB gene" CDS 2104171..2104287 /locus_tag="BSU_23349" /old_locus_tag="BSU23349" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:SOX90572.1" /translation="MYMHFESAQDDPITFARKAAAAFRVVKRIDRYLGFRKL*" /label="hypothetical protein CDS" gene 2104171..2104287 /locus_tag="BSU_23349" /old_locus_tag="BSU23349" /pseudo /label="gene" downshifts 2104238 /Source="Nicolas_upshifts" /id="D1219" /incds=0 /nref=3 /ntot=18 /MaxReadThrough="-0.179729999999999" /MaxDrop="3.76747" /score="-7.5033349" /energy="-9.1" /TU="NA" /idTUdmin="U1826" /TUdmin=198 /isTUend="FALSE" /label="downshifts" promotor_-35 2104364..2104373 /Source="Nicolas_upshift_promotors" /id="U1827" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1416 /SigmaFactorBS="aaacaggcatctcctaaatatttttgccgataagtttaCGCT AATCAActctagcactaaTACATATAAAAAATAGAATGatatgaaaggagacttgata g" /listShort="ypzD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2104386..2104405 /Source="Nicolas_upshift_promotors" /id="U1827" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1416 /SigmaFactorBS="aaacaggcatctcctaaatatttttgccgataagtttaCGCT AATCAActctagcactaaTACATATAAAAAATAGAATGatatgaaaggagacttgata g" /listShort="ypzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2104386 /Source="Nicolas_upshifts" /id="U1827" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1416 /SigmaFactorBS="aaacaggcatctcctaaatatttttgccgataagtttaCGCT AATCAActctagcactaaTACATATAAAAAATAGAATGatatgaaaggagacttgata g" /listShort="ypzD" /GFF_Attribute="listLong" /label="upshifts" CDS 2104428..2104640 /gene="ypzD" /locus_tag="BSU_23350" /old_locus_tag="BSU23350" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative germination protein" /protein_id="NP_390216.1" /db_xref="EnsemblGenomes-Gn:BSU23350" /db_xref="EnsemblGenomes-Tr:CAB14267" /db_xref="InterPro:IPR019618" /db_xref="SubtiList:BG13766" /db_xref="UniProtKB/Swiss-Prot:O32013" /translation="MIDYPININNVSGNSVINVGGAFMIRPLTLSKSVFGSGGLNTGI VFENNFVSKAKMINHQFTDQNVTKTF*" /label="ypzD CDS" gene 2104428..2104640 /gene="ypzD" /locus_tag="BSU_23350" /old_locus_tag="BSU23350" /label="ypzD gene" downshifts 2104634 /Source="Nicolas_upshifts" /id="D1220" /incds=0 /nref=4 /ntot=32 /MaxReadThrough="4.9048" /MaxDrop="3.6863" /score="3.56038753" /energy="-6.9" /TU="U1827" /idTUdmin="U1827" /TUdmin="-264" /isTUend="FALSE" /label="downshifts" downshifts complement(2104776) /Source="Nicolas_upshifts" /id="D1221" /incds=0 /nref=254 /ntot=263 /MaxReadThrough="2.52018" /MaxDrop="8.47213" /score="34.3429406" /energy="-12.4" /TU="NA" /idTUdmin="U1828" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2104776..2105207) /gene="ppiB" /locus_tag="BSU_23360" /old_locus_tag="BSU23360" /EC_number="5.2.1.8" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:8639516, 9063446, 9748346, 25184565" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8639516, 9063446, 9748346, 25184565; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptidyl-prolyl isomerase" /protein_id="NP_390217.1" /db_xref="EnsemblGenomes-Gn:BSU23360" /db_xref="EnsemblGenomes-Tr:CAB14268" /db_xref="GOA:P35137" /db_xref="InterPro:IPR002130" /db_xref="InterPro:IPR020892" /db_xref="InterPro:IPR024936" /db_xref="InterPro:IPR029000" /db_xref="SubtiList:BG10512" /db_xref="UniProtKB/Swiss-Prot:P35137" /translation="MKTGYFLLEDGNKIEFELYPEAAPGTVANFEKLANEGFYDGLTF HRVIPGFVSQGGCPHGTGTGGPGYTIKCETEGNPHTHEAGALSMAHAGKDTGGSQFFI VHEPQPHLNGVHTVFGKVTSGLEFAKNMSNGDVMKEVRVEG*" /label="ppiB CDS" gene complement(2104776..2105207) /gene="ppiB" /locus_tag="BSU_23360" /old_locus_tag="BSU23360" /label="ppiB gene" S_feature complement(2105208..2105294) /Source="Nicolas_S_feature" /locus_tag="new_2435792_2435878_c" /HighExp="dia5, dia15, dia0, Lbexp, LBGtran, C90, Lbtran, HPh, G180, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S886" promotor_-10 complement(2105277..2105296) /Source="Nicolas_upshift_promotors" /id="U1828" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.643356643356643" /psig=1 /xcortree=2355 /SigmaFactorBS="ttcaggtttcatttttattttttagtaaagctcgggagaTTC GTTttcccccgaaaggTGTGGTATAATAGCCGCGACaaggagagacaggctataacct a" /listShort="S886, ppiB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2105294) /Source="Nicolas_upshifts" /id="U1828" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.643356643356643" /psig=1 /xcortree=2355 /SigmaFactorBS="ttcaggtttcatttttattttttagtaaagctcgggagaTTC GTTttcccccgaaaggTGTGGTATAATAGCCGCGACaaggagagacaggctataacct a" /listShort="S886, ppiB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2105310..2105315) /Source="Nicolas_upshift_promotors" /id="U1828" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.643356643356643" /psig=1 /xcortree=2355 /SigmaFactorBS="ttcaggtttcatttttattttttagtaaagctcgggagaTTC GTTttcccccgaaaggTGTGGTATAATAGCCGCGACaaggagagacaggctataacct a" /listShort="S886, ppiB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2105344..2105353 /Source="Nicolas_upshift_promotors" /id="U1829" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1655 /SigmaFactorBS="gggggaaaacgaatctcccgagctttactaaaaaataaaaaT GAAACCTGAatctctttatctCCGTCTAACCTAACGGaactgtatttttcatgattca g" /listShort="S887, ypuA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2105363..2105460 /Source="Nicolas_S_feature" /locus_tag="new_2435947_2436044" /HighExp="Heat, Etha, Salt, dia0, HiTm, T0.30H, B60, Lbexp, T1.0H, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S887" upshifts 2105363 /Source="Nicolas_upshifts" /id="U1829" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1655 /SigmaFactorBS="gggggaaaacgaatctcccgagctttactaaaaaataaaaaT GAAACCTGAatctctttatctCCGTCTAACCTAACGGaactgtatttttcatgattca g" /listShort="S887, ypuA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2105366..2105381 /Source="Nicolas_upshift_promotors" /id="U1829" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1655 /SigmaFactorBS="gggggaaaacgaatctcccgagctttactaaaaaataaaaaT GAAACCTGAatctctttatctCCGTCTAACCTAACGGaactgtatttttcatgattca g" /listShort="S887, ypuA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2105461..2106333 /gene="ypuA" /locus_tag="BSU_23370" /old_locus_tag="BSU23370" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17434969, 18179421, 24706874; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_390218.1" /db_xref="EnsemblGenomes-Gn:BSU23370" /db_xref="EnsemblGenomes-Tr:CAB14269" /db_xref="InterPro:IPR009343" /db_xref="SubtiList:BG10511" /db_xref="UniProtKB/Swiss-Prot:P31847" /translation="MKKIWIGMLAAAVLLLMVPKVSLADAAVGDVIVTLGADLSESDK QKVLDEMNVPDNATTVTVTNKEEHEYLGKYISNAQIGSRAISSSSITIAKKGSGLNVE THNISGITDEMYLNALMTAGVKDAKVYVTAPFEVSGTAALTGLIKAYEVSSDEAISED VKQVANQELVTTSELGDKIGNENAAALIAKIKEEFAKNGVPDNKADIEKQVDDAASDL NVTLTDSQKNQLVSLFNKMKNADIDWGQVSDQLDKAKDKITKFIESDEGKNFIQKVID FFVSIWNAIVSIFK*" /label="ypuA CDS" gene 2105461..2106333 /gene="ypuA" /locus_tag="BSU_23370" /old_locus_tag="BSU23370" /label="ypuA gene" downshifts 2106240 /Source="Nicolas_upshifts" /id="D1222" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="5.9994" /MaxDrop="4.15288" /score="27.7277161" /energy="-12.7" /TU="U1829" /idTUdmin="U1829" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" downshifts 2106306 /Source="Nicolas_upshifts" /id="D1223" /incds=0 /nref=104 /ntot=219 /MaxReadThrough="1.98749" /MaxDrop="5.95835" /score="27.7277161" /energy="-12.7" /TU="NA" /idTUdmin="U1829" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2106363..2107682) /gene="lysA" /locus_tag="BSU_23380" /old_locus_tag="BSU23380" /EC_number="4.1.1.20" /experiment="publication(s) with functional evidences, PMID:9044297, 14627808" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9044297, 14627808; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="meso-2,6-diaminopimelate decarboxylase" /protein_id="NP_390219.1" /db_xref="EnsemblGenomes-Gn:BSU23380" /db_xref="EnsemblGenomes-Tr:CAB14270" /db_xref="GOA:P23630" /db_xref="InterPro:IPR000183" /db_xref="InterPro:IPR002986" /db_xref="InterPro:IPR009006" /db_xref="InterPro:IPR022643" /db_xref="InterPro:IPR022644" /db_xref="InterPro:IPR022653" /db_xref="InterPro:IPR022657" /db_xref="InterPro:IPR029066" /db_xref="SubtiList:BG10510" /db_xref="UniProtKB/Swiss-Prot:P23630" /translation="MFLHGTSRQNQHGHLEIGGVDALYLAEKYGTPLYVYDVALIRER AKSFKQAFISAGLKAQVAYASKAFSSVAMIQLAEEEGLSLDVVSGGELYTAVAAGFPA ERIHFHGNNKSREELRMALEHRIGCIVVDNFYEIALLEDLCKETGHSIDVLLRITPGV EAHTHDYITTGQEDSKFGFDLHNGQTERAIEQVLQSEHIQLLGVHCHIGSQIFDTAGF VLAAEKIFKKLDEWRDSYSFVSKVLNLGGGFGIRYTEDDEPLHATEYVEKIIEAVKEN ASRYGFDIPEIWIEPGRSLVGDAGTTLYTVGSQKEVPGVRQYVAVDGGMNDNIRPALY QAKYEAAAANRIGEAHDKTVSIAGKCCESGDMLIWDIDLPEVKEGDLLAVFCTGAYGY SMANNYNRIPRPAVVFVENGEAHLVVKRETYEDIVKLDLPFKTGVKQ*" /label="lysA CDS" gene complement(2106363..2107682) /gene="lysA" /locus_tag="BSU_23380" /old_locus_tag="BSU23380" /label="lysA gene" downshifts complement(2106383) /Source="Nicolas_upshifts" /id="D1224" /incds=0 /nref=192 /ntot=251 /MaxReadThrough="2.99445" /MaxDrop="5.13504" /score="28.6775009" /energy="-12.7" /TU="NA" /idTUdmin="U1830" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2107683..2107747) /Source="Nicolas_S_feature" /locus_tag="new_2438267_2438331_c" /HighExp="C90, HiOs, BMM, GM 120, GM 25, MG-0.2, GM 15, GM-0.2, MG t5, MG 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF" /TUshortPSig="0.996, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S888" promotor_-10 complement(2107743..2107762) /Source="Nicolas_upshift_promotors" /id="U1830" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.711288711288711" /psig="0.996003996003996" /xcortree=3075 /SigmaFactorBS="ggcagcctaccaattcataatcgCATTGAAActgactgaaga gtaTGATAATGTATGTCTTAATTatgaagggacagtccataaaactgtcctttcatcc a" /listShort="S888, lysA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2107747) /Source="Nicolas_upshifts" /id="U1830" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.711288711288711" /psig="0.996003996003996" /xcortree=3075 /SigmaFactorBS="ggcagcctaccaattcataatcgCATTGAAActgactgaaga gtaTGATAATGTATGTCTTAATTatgaagggacagtccataaaactgtcctttcatcc a" /listShort="S888, lysA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2107777..2107784) /Source="Nicolas_upshift_promotors" /id="U1830" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.711288711288711" /psig="0.996003996003996" /xcortree=3075 /SigmaFactorBS="ggcagcctaccaattcataatcgCATTGAAActgactgaaga gtaTGATAATGTATGTCTTAATTatgaagggacagtccataaaactgtcctttcatcc a" /listShort="S888, lysA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2107788..2109269) /gene="spoVAF" /locus_tag="BSU_23390" /old_locus_tag="BSU23390" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16077113, 17573930, 24682327, 26604257" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16077113, 17573930, 24682327, 26604257; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage V sporulation protein AF" /protein_id="NP_390220.2" /db_xref="EnsemblGenomes-Gn:BSU23390" /db_xref="EnsemblGenomes-Tr:CAB14271" /db_xref="GOA:P31845" /db_xref="InterPro:IPR004995" /db_xref="SubtiList:BG10508" /db_xref="UniProtKB/Swiss-Prot:P31845" /translation="MPDHKEEKIRVYRNPAKNEEYFKNRVGMGTSYDVGVRKLTILDK EIQLYYLNGLCDTAYIIHLMRELVAINNRKEDPDELVDIVENRLLNAQVEKVKTLDET TDQVLSGLVAVIVEGAGFAFIIDVRSYPGRNPEEPDTEKVVRGARDGFVENIVVNTAL LRRRIRDERLRVKMTKVGERSKTDLSICYIEDIADPDLVEIVEKEIASIDVDGLTMAD KTVEEFIVNQSYNPFPLVRYTERPDVAANHVLEGHVIIIVDTSPSVIITPTTLFHHVQ HAEEYRQAPSVGTFLRWVRFFGILASTLFLPIWFLFVLQPDLLPDNMKFIGLNKDTHI PIILQIFLADLGIEFLRMAAIHTPTALSTAMGLIAAVLIGQIAIEVGLFSPEVILYVS LAAIGTFTTPSYELSLANKMSRLVLMILVALFHIKGLVIGFTVLIIAMASIKSLQTPY LWPLIPFNGKALWQVLVRTAKPGAKVRPSIVHPKNRLRQPTNS*" /label="spoVAF CDS" gene complement(2107788..2109269) /gene="spoVAF" /locus_tag="BSU_23390" /old_locus_tag="BSU23390" /label="spoVAF gene" misc_feature complement(2108494..2108513) /Source="Nicolas_upshift_promotors" /id="U1831" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.95004995004995" /psig="0.998001998001998" /xcortree=2143 /SigmaFactorBS="tatacagaaagaccggatgtggccgcaaatcatgttctagaa ggcCATGTTATCATTATAGTGGAcacatcgccgagtgtgatcattaccccgacgactt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2108498) /Source="Nicolas_upshifts" /id="U1831" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.95004995004995" /psig="0.998001998001998" /xcortree=2143 /SigmaFactorBS="tatacagaaagaccggatgtggccgcaaatcatgttctagaa ggcCATGTTATCATTATAGTGGAcacatcgccgagtgtgatcattaccccgacgactt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2109220..2109831) /gene="spoVAEA" /locus_tag="BSU_23401" /old_locus_tag="BSU23401" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16077113, 17573930, 24682327, 26604257" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16077113, 17573930, 24682327, 26604257; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage V sporulation germinant protein" /protein_id="YP_003097758.1" /db_xref="EnsemblGenomes-Gn:BSU23401" /db_xref="EnsemblGenomes-Tr:CAX52658" /db_xref="GOA:P40870" /db_xref="InterPro:IPR025914" /db_xref="UniProtKB/Swiss-Prot:P40870" /translation="MTTKRKVILVTDGDVYAAKTIEYAASKVGGRCISQSKGNPSTRS GAELVKLIASAPYDPVFVMFDDSGLQGEGPGEAALTYVATHPSIEVLGVIAVASKTHQ AEWTRVDVSIDRNGEITEYGVDKVGEREFDDHRMSGDTVYCLDKLDLPLIVGIGDIGK MGRKDDISKGSPITMKAVEFILERSGYHAGPQGRENSGLSESS*" /label="spoVAEA CDS" gene complement(2109220..2109831) /gene="spoVAEA" /locus_tag="BSU_23401" /old_locus_tag="BSU23401" /label="spoVAEA gene" CDS complement(2109839..2110189) /gene="spoVAEB" /locus_tag="BSU_23402" /old_locus_tag="BSU23402" /experiment="publication(s) with functional evidences, PMID:17573930, 26604257, 27105070" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17573930, 26604257, 27105070; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germinant protein" /protein_id="YP_003097759.1" /db_xref="EnsemblGenomes-Gn:BSU23402" /db_xref="EnsemblGenomes-Tr:CAX52659" /db_xref="GOA:C0H450" /db_xref="InterPro:IPR005562" /db_xref="InterPro:IPR014204" /db_xref="UniProtKB/Swiss-Prot:C0H450" /translation="MDYLLAFVCGGAICIVGQLLLDIFKLTPAHVMTSFVVIGAILDG FGIYDKFIEFAGGGATVPIVSFGHSLLHGAMHQAHIHGFIGIGMGIFELTSAGISAAI LFAFIVAVIFKPKG*" /label="spoVAEB CDS" gene complement(2109839..2110189) /gene="spoVAEB" /locus_tag="BSU_23402" /old_locus_tag="BSU23402" /label="spoVAEB gene" CDS complement(2110191..2111207) /gene="spoVAD" /locus_tag="BSU_23410" /old_locus_tag="BSU23410" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16077113, 22328679, 26604257, 27105070" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16077113, 22328679, 26604257, 27105070; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage V sporulation protein AD (uptake of pyridine-2,6-dicarboxylic acid)" /protein_id="NP_390222.1" /db_xref="EnsemblGenomes-Gn:BSU23410" /db_xref="EnsemblGenomes-Tr:CAB14273" /db_xref="GOA:P40869" /db_xref="InterPro:IPR010894" /db_xref="InterPro:IPR016039" /db_xref="PDB:3LM6" /db_xref="SubtiList:BG10895" /db_xref="UniProtKB/Swiss-Prot:P40869" /translation="MKLTGKQTWVFEHPIFVNSAGTAAGPKEKDGPLGSLFDKTYDEM HCNQKSWEMAERQLMEDAVNVALQKNNLTKDDIDLLLAGDLLNQNVTANYVARHLKIP FLCMFGACSTSMETVAVASALVDGGFAKRALAATSSHNATAERQFRYPTEYGGQKPDT ATSTVTGSGAVVISQTPGDIQITSATVGKVSDLGITDPFDMGSAMAPAAADTIKQHFK DLNRTADDYDLILTGDLSGVGSPIVKDILKEDGYPVGTKHDDCGLLIYTPDQQVFAGG SGCACSAVVTYSHIFKQLREGKLNRVFVVATGALLSPTMIQQKETIPTIAHGVVFERA GGAS*" /label="spoVAD CDS" gene complement(2110191..2111207) /gene="spoVAD" /locus_tag="BSU_23410" /old_locus_tag="BSU23410" /label="spoVAD gene" promotor_-35 2110687..2110694 /Source="Nicolas_upshift_promotors" /id="U1832" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.711288711288711" /psig="0.987012987012987" /xcortree=627 /SigmaFactorBS="tatcacccggtgtctgaCTGATGACaactgcaccgcttCCGG TTACAGTGGAGGTAGCagtgtccggtttttggcctccgtattctgtcggatagcgaaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2110708..2110727 /Source="Nicolas_upshift_promotors" /id="U1832" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.711288711288711" /psig="0.987012987012987" /xcortree=627 /SigmaFactorBS="tatcacccggtgtctgaCTGATGACaactgcaccgcttCCGG TTACAGTGGAGGTAGCagtgtccggtttttggcctccgtattctgtcggatagcgaaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2110730 /Source="Nicolas_upshifts" /id="U1832" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.711288711288711" /psig="0.987012987012987" /xcortree=627 /SigmaFactorBS="tatcacccggtgtctgaCTGATGACaactgcaccgcttCCGG TTACAGTGGAGGTAGCagtgtccggtttttggcctccgtattctgtcggatagcgaaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2111220..2111672) /gene="spoVAC" /locus_tag="BSU_23420" /old_locus_tag="BSU23420" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15849754, 16077113, 16850406, 24666282, 26604257, 27105070" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16077113, 16850406, 24666282, 26604257, 27105070; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="mechanosensitive channel; stage V sporulation protein AC" /protein_id="NP_390223.1" /db_xref="EnsemblGenomes-Gn:BSU23420" /db_xref="EnsemblGenomes-Tr:CAB14274" /db_xref="GOA:P40868" /db_xref="InterPro:IPR005562" /db_xref="InterPro:IPR014203" /db_xref="SubtiList:BG10894" /db_xref="UniProtKB/Swiss-Prot:P40868" /translation="MTNIKENYKSKVKTYQPKPPYVWNCVKAFLVGGLICAIGQGLQN FYIHFFDFNEKTAGNPTAATLILISALLTGFGIYDRIGQFAGAGSAVPVTGFANSMAS AALEYKSEGLVLGVATNMFKLAGNVIVFGVVAAYIVGMIRFAFEKLMS*" /label="spoVAC CDS" gene complement(2111220..2111672) /gene="spoVAC" /locus_tag="BSU_23420" /old_locus_tag="BSU23420" /label="spoVAC gene" CDS complement(2111685..2112110) /gene="spoVAB" /locus_tag="BSU_23430" /old_locus_tag="BSU23430" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15849754, 16077113, 16850406, 26604257" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16077113, 16850406, 26604257; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage V sporulation protein AB" /protein_id="NP_390224.1" /db_xref="EnsemblGenomes-Gn:BSU23430" /db_xref="EnsemblGenomes-Tr:CAB14275" /db_xref="GOA:P40867" /db_xref="InterPro:IPR020144" /db_xref="SubtiList:BG10893" /db_xref="UniProtKB/Swiss-Prot:P40867" /translation="MIVSVLFIIFVGLGGGITVGAGFVAFLTVMGIIPRLMQLTKTMR FVQAYEAAVILGAVCGGWETLHMNHLYLTKWIAVPVGLLAGLFVGMLAAALTEVLNVL PILAKRIGLRSKIIILLMAIVIGKIAGSLFHWLYFIDHS*" /label="spoVAB CDS" gene complement(2111685..2112110) /gene="spoVAB" /locus_tag="BSU_23430" /old_locus_tag="BSU23430" /label="spoVAB gene" CDS complement(2112100..2112720) /gene="spoVAA" /locus_tag="BSU_23440" /old_locus_tag="BSU23440" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:3114420, 26604257" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3114420, 26604257; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage V sporulation protein AA" /protein_id="NP_390225.2" /db_xref="EnsemblGenomes-Gn:BSU23440" /db_xref="EnsemblGenomes-Tr:CAB14276" /db_xref="GOA:P40866" /db_xref="InterPro:IPR021997" /db_xref="SubtiList:BG10892" /db_xref="UniProtKB/Swiss-Prot:P40866" /translation="MERRIFIRLRHRVLAHPGDIITVGDAAQIEGQLQLKKKLSAMPL YQVSEKDKNIVILDIIQVLRAIHLQDPTIDVQTVGGAETIVEIQYRKRNLSTVLFIGV WLLLFIGSCLAIMNFHEDVSMRDVHIALYEIITGERNDYPYLLQIPYSIGLGLGMIVF FNHIFKKRLNEEPSPLEVEMFNYQLDLDQYVAMHENQETIKDLHDR*" /label="spoVAA CDS" gene complement(2112100..2112720) /gene="spoVAA" /locus_tag="BSU_23440" /old_locus_tag="BSU23440" /label="spoVAA gene" promotor_-10 complement(2112751..2112762) /Source="Nicolas_upshift_promotors" /id="U1833" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=924 /SigmaFactorBS="tgtgcaaaagcgtggtaatttatggtcttttcgagcggaTGA ATGAgaacaaaatcgaaCCACATACTACAtatataaccaccgaaagatggtgatcaat g" /listShort="spoVAA, spoVAB, spoVAC, spoVAD, spoVAEB, spoVAEA, spoVAF, S888, lysA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2112761) /Source="Nicolas_upshifts" /id="U1833" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=924 /SigmaFactorBS="tgtgcaaaagcgtggtaatttatggtcttttcgagcggaTGA ATGAgaacaaaatcgaaCCACATACTACAtatataaccaccgaaagatggtgatcaat g" /listShort="spoVAA, spoVAB, spoVAC, spoVAD, spoVAEB, spoVAEA, spoVAF, S888, lysA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2112776..2112782) /Source="Nicolas_upshift_promotors" /id="U1833" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=924 /SigmaFactorBS="tgtgcaaaagcgtggtaatttatggtcttttcgagcggaTGA ATGAgaacaaaatcgaaCCACATACTACAtatataaccaccgaaagatggtgatcaat g" /listShort="spoVAA, spoVAB, spoVAC, spoVAD, spoVAEB, spoVAEA, spoVAF, S888, lysA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2112845..2113612) /gene="sigF" /locus_tag="BSU_23450" /old_locus_tag="BSU23450" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9891799, 15187183, 15205417, 15819616, 16045607, 22115775, 23169620, 24067622, 26506528" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9891799, 15187183, 15205417, 15819616, 16045607, 22115775, 23169620, 24067622, 26506528; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="RNA polymerase sporulation-specific sigma factor(sigma-F)" /protein_id="NP_390226.1" /db_xref="EnsemblGenomes-Gn:BSU23450" /db_xref="EnsemblGenomes-Tr:CAB14277" /db_xref="GOA:P07860" /db_xref="InterPro:IPR000943" /db_xref="InterPro:IPR007624" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR007630" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014236" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR014322" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10298" /db_xref="UniProtKB/Swiss-Prot:P07860" /translation="MDVEVKKNGKNAQLKDHEVKELIKQSQNGDQQARDLLIEKNMRL VWSVVQRFLNRGYEPDDLFQIGCIGLLKSVDKFDLTYDVRFSTYAVPMIIGEIQRFIR DDGTVKVSRSLKELGNKIRRAKDELSKTLGRVPTVQEIADHLEIEAEDVVLAQEAVRA PSSIHETVYENDGDPITLLDQIADNSEEKWFDKIALKEAISDLEEREKLIVYLRYYKD QTQSEVAERLGISQVQVSRLEKKILKQIKVQMDHTDG*" /label="sigF CDS" gene complement(2112845..2113612) /gene="sigF" /locus_tag="BSU_23450" /old_locus_tag="BSU23450" /label="sigF gene" downshifts complement(2112875) /Source="Nicolas_upshifts" /id="D1225" /incds=0 /nref=89 /ntot=197 /MaxReadThrough="1.81932" /MaxDrop="7.16571" /score="21.6169221" /energy="-13.5" /TU="NA" /idTUdmin="U1834" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(2113624..2114064) /gene="spoIIAB" /locus_tag="BSU_23460" /old_locus_tag="BSU23460" /EC_number="2.7.11.-" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15023063, 15187183, 15819616, 16166546, 16824103, 22115775" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15023063, 15187183, 15819616, 16166546, 16824103, 22115775; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="anti-sigma factor (antagonist of sigma(F)) and serine kinase" /protein_id="NP_390227.1" /db_xref="EnsemblGenomes-Gn:BSU23460" /db_xref="EnsemblGenomes-Tr:CAB14278" /db_xref="GOA:P10728" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR010194" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10297" /db_xref="UniProtKB/Swiss-Prot:P10728" /translation="MKNEMHLEFSALSQNESFARVTVASFIAQLDPTMDELTEIKTVV SEAVTNAIIHGYEENCEGKVYISVTLEDHVVYMTIRDEGLGITDLEEARQPLFTTKPE LERSGMGFTIMENFMDDVSIDSSPEMGTTIRLTKHLSKSKALCN*" /label="spoIIAB CDS" gene complement(2113624..2114064) /gene="spoIIAB" /locus_tag="BSU_23460" /old_locus_tag="BSU23460" /label="spoIIAB gene" CDS complement(2114061..2114414) /gene="spoIIAA" /locus_tag="BSU_23470" /old_locus_tag="BSU23470" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11173484, 15819616, 16824103, 22115775" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11173484, 15819616, 16824103, 22115775; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="anti-anti-sigma factor (antagonist of SpoIIAB)" /protein_id="NP_390228.1" /db_xref="EnsemblGenomes-Gn:BSU23470" /db_xref="EnsemblGenomes-Tr:CAB14279" /db_xref="GOA:P10727" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR003658" /db_xref="InterPro:IPR014237" /db_xref="InterPro:IPR036513" /db_xref="PDB:1AUZ" /db_xref="PDB:1BUZ" /db_xref="SubtiList:BG10296" /db_xref="UniProtKB/Swiss-Prot:P10727" /translation="MSLGIDMNVKESVLCIRLTGELDHHTAETLKQKVTQSLEKDDIR HIVLNLEDLSFMDSSGLGVILGRYKQIKQIGGEMVVCAISPAVKRLFDMSGLFKIIRF EQSEQQALLTLGVAS*" /label="spoIIAA CDS" gene complement(2114061..2114414) /gene="spoIIAA" /locus_tag="BSU_23470" /old_locus_tag="BSU23470" /label="spoIIAA gene" promotor_-10 complement(2114439..2114457) /Source="Nicolas_upshift_promotors" /id="U1834" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=445 /SigmaFactorBS="attatgccgaatgaccactagttttgtcacggtGAAGGAATT cattccgtcgaAATCGAAACACTCATTATCcgatcatatcaaggaggaatgagcatga g" /listShort="spoIIAA, spoIIAB, sigF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2114450) /Source="Nicolas_upshifts" /id="U1834" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=445 /SigmaFactorBS="attatgccgaatgaccactagttttgtcacggtGAAGGAATT cattccgtcgaAATCGAAACACTCATTATCcgatcatatcaaggaggaatgagcatga g" /listShort="spoIIAA, spoIIAB, sigF" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2114452..2114509) /Source="Nicolas_S_feature" /locus_tag="new_2445036_2445093_c" /HighExp="S4, S3, S7, S5, S8, S6, T5.0H, BT, LoTm, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.859" /TUlongSig="NA" /TUlongPSig="NA" /label="S889" promotor_-35 complement(2114469..2114477) /Source="Nicolas_upshift_promotors" /id="U1834" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=445 /SigmaFactorBS="attatgccgaatgaccactagttttgtcacggtGAAGGAATT cattccgtcgaAATCGAAACACTCATTATCcgatcatatcaaggaggaatgagcatga g" /listShort="spoIIAA, spoIIAB, sigF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2114510..2115679) /gene="dacF" /locus_tag="BSU_23480" /old_locus_tag="BSU23480" /EC_number="3.4.16.4" /function="16.8: Protect" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:8021191, 8936302, 9864321, 19189487" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8021191, 8936302, 9864321, 19189487; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanyl-D-alanine carboxypeptidase (penicilin binding protein)" /protein_id="NP_390229.1" /db_xref="EnsemblGenomes-Gn:BSU23480" /db_xref="EnsemblGenomes-Tr:CAB14280" /db_xref="GOA:P38422" /db_xref="InterPro:IPR001967" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR012907" /db_xref="InterPro:IPR015956" /db_xref="InterPro:IPR018044" /db_xref="InterPro:IPR037167" /db_xref="SubtiList:BG10295" /db_xref="UniProtKB/Swiss-Prot:P38422" /translation="MKRLLSTLLIGIMLLTFAPSAFAKQDGKRTSELAHEAKSAVLIE RDTGKVLYNKNSNERLAPASMTKIMTMLLIMEALDKGKIKMSDKVRTSEHAASMGGSQ IFLEPGEEMTVKEMLKGIAIASGNDASVAMAEFISGSEEEFVKKMNKKAKELGLKNTS FKNPTGLTEEGHYSSAYDMAIMAKELLKYESITKFTGTYEDYLRENTDKKFWLVNTNR LIKFYPGVDGVKTGYTGEAKYCLTASAKKGNMRAIAVVFGASTPKERNAQVTKMLDFA FSQYETHPLYKRNQTVAKVKVKKGKQKFIELTTSEPISILTKKGEDMNDVKKEIKMKD NISAPIQKGQELGTLVLKKDGEVLAESPVAAKEDMKKAGFITFLKRTMGDWTKFK*" /label="dacF CDS" gene complement(2114510..2115679) /gene="dacF" /locus_tag="BSU_23480" /old_locus_tag="BSU23480" /label="dacF gene" promotor_-10 complement(2115708..2115719) /Source="Nicolas_upshift_promotors" /id="U1835" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.85914085914086" /psig="0.85914085914086" /xcortree=1155 /SigmaFactorBS="tgtctttttttatgcccaaaattcgaaacattttccatcagt ggCGTATAAaaccatcacgcttGGAAAAAATAAAaaggattatgaaatggagggcttt t" /listShort="dacF, S889, spoIIAA, spoIIAB, sigF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2115723) /Source="Nicolas_upshifts" /id="U1835" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.85914085914086" /psig="0.85914085914086" /xcortree=1155 /SigmaFactorBS="tgtctttttttatgcccaaaattcgaaacattttccatcagt ggCGTATAAaaccatcacgcttGGAAAAAATAAAaaggattatgaaatggagggcttt t" /listShort="dacF, S889, spoIIAA, spoIIAB, sigF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2115733..2115739) /Source="Nicolas_upshift_promotors" /id="U1835" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.85914085914086" /psig="0.85914085914086" /xcortree=1155 /SigmaFactorBS="tgtctttttttatgcccaaaattcgaaacattttccatcagt ggCGTATAAaaccatcacgcttGGAAAAAATAAAaaggattatgaaatggagggcttt t" /listShort="dacF, S889, spoIIAA, spoIIAB, sigF" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2115825) /Source="Nicolas_upshifts" /id="D1226" /incds=0 /nref=243 /ntot=267 /MaxReadThrough="0.87114" /MaxDrop="7.5376" /score="26.8559416" /energy="-16.7" /TU="NA" /idTUdmin="U1836" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2115834..2116649) /gene="pupG" /locus_tag="BSU_23490" /old_locus_tag="BSU23490" /EC_number="2.4.2.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10537218, 15530033, 21279421, 21543875" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10537218, 15530033, 21279421, 21543875; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="purine nucleoside phosphorylase" /protein_id="NP_390230.1" /db_xref="EnsemblGenomes-Gn:BSU23490" /db_xref="EnsemblGenomes-Tr:CAB14281" /db_xref="GOA:P46354" /db_xref="InterPro:IPR000845" /db_xref="InterPro:IPR011268" /db_xref="InterPro:IPR011270" /db_xref="InterPro:IPR018099" /db_xref="InterPro:IPR035994" /db_xref="SubtiList:BG11330" /db_xref="UniProtKB/Swiss-Prot:P46354" /translation="MKDRIERAAAFIKQNLPESPKIGLILGSGLGILADEIENPVKLK YEDIPEFPVSTVEGHAGQLVLGTLEGVSVIAMQGRFHFYEGYSMEKVTFPVRVMKALG VEALIVTNAAGGVNTEFRAGDLMIITDHINFMGTNPLIGPNEADFGARFPDMSSAYDK DLSSLAEKIAKDLNIPIQKGVYTAVTGPSYETPAEVRFLRTMGSDAVGMSTVPEVIVA NHAGMRVLGISCISNAAAGILDQPLSHDEVMEVTEKVKAGFLKLVKAIVAQYE*" /label="pupG CDS" gene complement(2115834..2116649) /gene="pupG" /locus_tag="BSU_23490" /old_locus_tag="BSU23490" /label="pupG gene" CDS complement(2116662..2117846) /gene="deoB" /locus_tag="BSU_23500" /old_locus_tag="BSU23500" /EC_number="5.4.2.7" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10537218, 26211718" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10537218, 26211718; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="1,5-phosphopentomutase" /protein_id="NP_390231.2" /db_xref="EnsemblGenomes-Gn:BSU23500" /db_xref="EnsemblGenomes-Tr:CAB14282" /db_xref="GOA:P46353" /db_xref="InterPro:IPR006124" /db_xref="InterPro:IPR010045" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="InterPro:IPR024052" /db_xref="SubtiList:BG11331" /db_xref="UniProtKB/Swiss-Prot:P46353" /translation="MPAYKYNRVFLIVMDSVGIGEAPDAADFNDEGAHTLGHIAEHMN GLHMPNMAKLGLGLIEDIKGVEKTEHPLAYYGKMQEASNGKDTMTGHWEIMGLYIDKP FKVFPEGFPDELLQELEKRSGRKIIGNKPASGTAILDELGQEHMETGALIVYTSADSV LQIAAHEEVVPLEELYRICETARELTLDPKYMVGRIIARPFVGEPGQFKRTPNRHDYA LKPFDRTVMNELKDCGLDVISIGKISDIYDGEGITSSRRTVSNMDGMDKVIDTLGEDF TGLSFANLVDFDALFGHRRDPEGYGRALEEFDARLPEVFEKMREDDLLIITADHGNDP IHHGTDHTREYVPILAYSKKHKKAQMLPLADTFADIGATIADNFQTNKPKYGKSFLSL LQ*" /label="deoB CDS" gene complement(2116662..2117846) /gene="deoB" /locus_tag="BSU_23500" /old_locus_tag="BSU23500" /label="deoB gene" promotor_-10 complement(2117895..2117914) /Source="Nicolas_upshift_promotors" /id="U1836" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=1806 /SigmaFactorBS="acagaaaatattgaagtttctcattatttccaaataCATTGT CAacgggaatgaaaacgGTTTATACTTGAGTTGTCAGacctcttagcgatacaataga c" /listShort="drm, pupG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2117913) /Source="Nicolas_upshifts" /id="U1836" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=1806 /SigmaFactorBS="acagaaaatattgaagtttctcattatttccaaataCATTGT CAacgggaatgaaaacgGTTTATACTTGAGTTGTCAGacctcttagcgatacaataga c" /listShort="drm, pupG" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2117915..2118006) /Source="Nicolas_S_feature" /locus_tag="new_2448499_2448590_c" /HighExp="S3, S4, M0t90, G180, S7, S8, Glucon, G135, S5, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB, SigEF, SigA" /TUshortPSig="1, 1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S890" promotor_-35 complement(2117930..2117937) /Source="Nicolas_upshift_promotors" /id="U1836" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=1806 /SigmaFactorBS="acagaaaatattgaagtttctcattatttccaaataCATTGT CAacgggaatgaaaacgGTTTATACTTGAGTTGTCAGacctcttagcgatacaataga c" /listShort="drm, pupG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2118007..2118897) /gene="ripX" /locus_tag="BSU_23510" /old_locus_tag="BSU23510" /function="16.9: Replicate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10498718, 11134515, 11208805, 16553881, 16597952, 21239579, 23305333" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10498718, 11134515, 11208805, 16553881, 16597952, 21239579, 23305333; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="site-specific tyrosine recombinase for chromosome partitioning" /protein_id="NP_390232.2" /db_xref="EnsemblGenomes-Gn:BSU23510" /db_xref="EnsemblGenomes-Tr:CAB14283" /db_xref="GOA:P46352" /db_xref="InterPro:IPR002104" /db_xref="InterPro:IPR004107" /db_xref="InterPro:IPR010998" /db_xref="InterPro:IPR011010" /db_xref="InterPro:IPR011932" /db_xref="InterPro:IPR013762" /db_xref="InterPro:IPR023009" /db_xref="SubtiList:BG11332" /db_xref="UniProtKB/Swiss-Prot:P46352" /translation="MKDQIKDFIHYVMVERGLSQNTIVSYERDLKSYSLYLTETLHVT DWNHVTRIHIIQYLKHLKDSGKSGKTSARHLASIRSFHQFLLREKVTDKDPSVHIETQ KTERALPKVLALNEVERLLDTPKLTSPFGYRDKAMLELLYATGIRVSEMIELKTADVH LSMGFIRCFGKGRKERIVPIGEAAASAIEEYMTKARGKLLKNNVSDALFLNHHGKQIS RQGFWKNLKKIALEAGIKKELTPHTLRHSFATHLLENGADLRAVQEMLGHADISTTQI YTHVTKTRLKDVYKQFHPRA*" /label="ripX CDS" gene complement(2118007..2118897) /gene="ripX" /locus_tag="BSU_23510" /old_locus_tag="BSU23510" /label="ripX gene" CDS complement(2118905..2119132) /gene="yqzK" /locus_tag="BSU_23519" /old_locus_tag="BSU23519" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097760.1" /db_xref="EnsemblGenomes-Gn:BSU23519" /db_xref="EnsemblGenomes-Tr:CAX52660" /db_xref="GOA:C0H451" /db_xref="InterPro:IPR025321" /db_xref="UniProtKB/Swiss-Prot:C0H451" /translation="MGRFLKTAVDALKVFILFTGFTALFYYAMIWVNQEYENYHRYDK PEGSAVKVVEMDQDEKGGWFDRLIFFYQNGE*" /label="yqzK CDS" gene complement(2118905..2119132) /gene="yqzK" /locus_tag="BSU_23519" /old_locus_tag="BSU23519" /label="yqzK gene" promotor_-10 complement(2119035..2119054) /Source="Nicolas_upshift_promotors" /id="U1837" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.835164835164835" /psig=1 /xcortree=3146 /SigmaFactorBS="cgatgcattgaaagttttcatcctgtttaccGGTTTTACcgc tttgttctatTATGCTATGATATGGGTGAAtcaagagtatgaaaactatcatcggtat g" /listShort="ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2119046) /Source="Nicolas_upshifts" /id="U1837" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.835164835164835" /psig=1 /xcortree=3146 /SigmaFactorBS="cgatgcattgaaagttttcatcctgtttaccGGTTTTACcgc tttgttctatTATGCTATGATATGGGTGAAtcaagagtatgaaaactatcatcggtat g" /listShort="ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2119068..2119075) /Source="Nicolas_upshift_promotors" /id="U1837" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.835164835164835" /psig=1 /xcortree=3146 /SigmaFactorBS="cgatgcattgaaagttttcatcctgtttaccGGTTTTACcgc tttgttctatTATGCTATGATATGGGTGAAtcaagagtatgaaaactatcatcggtat g" /listShort="ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2119125) /Source="Nicolas_upshifts" /id="U1838" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=180 /SigmaFactorBS="atttggcatatGGTTTATataactggaaccataGGGAAAGGA TCGATTAGGAcatgggaagattcctgaaaacagctgtcgatgcattgaaagttttcat c" /listShort="yqzK, ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2119134..2119152) /Source="Nicolas_upshift_promotors" /id="U1838" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=180 /SigmaFactorBS="atttggcatatGGTTTATataactggaaccataGGGAAAGGA TCGATTAGGAcatgggaagattcctgaaaacagctgtcgatgcattgaaagttttcat c" /listShort="yqzK, ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2119162..2119180) /Source="Nicolas_upshift_promotors" /id="U1839" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1165 /SigmaFactorBS="ttctcatggggaaagggttttttgctgtttctaTGTATAaaa cctttctgatttgGCATATGGTTTATATAACTggaaccatagggaaaggatcgattag g" /listShort="yqzK, ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2119168..2119174) /Source="Nicolas_upshift_promotors" /id="U1838" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=180 /SigmaFactorBS="atttggcatatGGTTTATataactggaaccataGGGAAAGGA TCGATTAGGAcatgggaagattcctgaaaacagctgtcgatgcattgaaagttttcat c" /listShort="yqzK, ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2119175) /Source="Nicolas_upshifts" /id="U1839" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1165 /SigmaFactorBS="ttctcatggggaaagggttttttgctgtttctaTGTATAaaa cctttctgatttgGCATATGGTTTATATAACTggaaccatagggaaaggatcgattag g" /listShort="yqzK, ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2119197..2119202) /Source="Nicolas_upshift_promotors" /id="U1839" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1165 /SigmaFactorBS="ttctcatggggaaagggttttttgctgtttctaTGTATAaaa cctttctgatttgGCATATGGTTTATATAACTggaaccatagggaaaggatcgattag g" /listShort="yqzK, ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2119257) /Source="Nicolas_upshifts" /id="D1227" /incds=0 /nref=159 /ntot=251 /MaxReadThrough="4.06128" /MaxDrop="5.73495" /score="5.40881961" /energy="-8.1" /TU="U1840" /idTUdmin="U1841" /TUdmin=506 /isTUend="FALSE" /label="downshifts" CDS complement(2119257..2119706) /gene="fur" /locus_tag="BSU_23520" /old_locus_tag="BSU23520" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12029044, 12374814, 14563870, 15802251, 16672620, 25160631, 25209494" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12029044, 12374814, 14563870, 15802251, 16672620, 25160631, 25209494; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator for iron transport andmetabolism" /protein_id="NP_390233.2" /db_xref="EnsemblGenomes-Gn:BSU23520" /db_xref="EnsemblGenomes-Tr:CAB14284" /db_xref="GOA:P54574" /db_xref="InterPro:IPR002481" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11766" /db_xref="UniProtKB/Swiss-Prot:P54574" /translation="MENRIDRIKKQLHSSSYKLTPQREATVRVLLENEEDHLSAEDVY LLVKEKSPEIGLATVYRTLELLTELKVVDKINFGDGVSRYDLRKEGAAHFHHHLVCME CGAVDEIEEDLLEDVEEIIERDWKFKIKDHRLTFHGICHRCNGKETE*" /label="fur CDS" gene complement(2119257..2119706) /gene="fur" /locus_tag="BSU_23520" /old_locus_tag="BSU23520" /label="fur gene" promotor_-10 complement(2119730..2119749) /Source="Nicolas_upshift_promotors" /id="U1840" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.893106893106893" /psig=1 /xcortree=2743 /SigmaFactorBS="accattttatttatcagtttataataattatAGTTGgaactc tgcgcgtatTTTGTTATAATGAGTCATGGaatgcggcgtaggagggaaagacatggaa a" /listShort="fur, yqzK, ripX, S890" /listLong="drm, pupG" /label="promotor_-10" upshifts complement(2119740) /Source="Nicolas_upshifts" /id="U1840" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.893106893106893" /psig=1 /xcortree=2743 /SigmaFactorBS="accattttatttatcagtttataataattatAGTTGgaactc tgcgcgtatTTTGTTATAATGAGTCATGGaatgcggcgtaggagggaaagacatggaa a" /listShort="fur, yqzK, ripX, S890" /listLong="drm, pupG" /label="upshifts" S_feature complement(2119742..2119818) /Source="Nicolas_S_feature" /locus_tag="new_2450326_2450402_c" /HighExp="S3, S4, S5, BT, LoTm, M9-stat, T5.0H, T3.30H, T4.0H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S891" promotor_-35 complement(2119765..2119769) /Source="Nicolas_upshift_promotors" /id="U1840" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.893106893106893" /psig=1 /xcortree=2743 /SigmaFactorBS="accattttatttatcagtttataataattatAGTTGgaactc tgcgcgtatTTTGTTATAATGAGTCATGGaatgcggcgtaggagggaaagacatggaa a" /listShort="fur, yqzK, ripX, S890" /listLong="drm, pupG" /label="promotor_-35" CDS complement(2119819..2120463) /gene="spoIIM" /locus_tag="BSU_23530" /old_locus_tag="BSU23530" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 17376078, 17824930, 20382772, 23859254" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 17376078, 17824930, 20382772, 23859254; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="autolysin component for dissolution of the septal cell wall (stage II sporulation)" /protein_id="NP_390234.1" /db_xref="EnsemblGenomes-Gn:BSU23530" /db_xref="EnsemblGenomes-Tr:CAB14285" /db_xref="GOA:P37873" /db_xref="InterPro:IPR002798" /db_xref="InterPro:IPR014196" /db_xref="SubtiList:BG10768" /db_xref="UniProtKB/Swiss-Prot:P37873" /translation="MRKISYKDMFLRHVKDHLSLYIFVSVLFFMGVIFGAIIVNSMTI SQKEDLYYYLSQFFGQLSDGKQASSADMFGQSIFHNAKYLGLMWILGISVIGMPIIFI MIFLKGIVVGFTVGFLVNQMGVSGFFLSFVSVLPQNVLLIPAYLIMGTCAIAFSLKLI RQLFVKRSLHDAPIQWFGRYAFVLLVILFLALISSLFEAYLSPVLMEKLTSRLF*" /label="spoIIM CDS" gene complement(2119819..2120463) /gene="spoIIM" /locus_tag="BSU_23530" /old_locus_tag="BSU23530" /label="spoIIM gene" promotor_-10 complement(2120494..2120512) /Source="Nicolas_upshift_promotors" /id="U1841" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=995 /SigmaFactorBS="ccgcctagcattcatctctattgtttctttttgaaaaagGGC ATGtttttctgtttcttTCATACAATCTATTAAATCaaatcactagagcgggcgggag g" /listShort="spoIIM, S891" /listLong="fur" /label="promotor_-10" upshifts complement(2120511) /Source="Nicolas_upshifts" /id="U1841" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=995 /SigmaFactorBS="ccgcctagcattcatctctattgtttctttttgaaaaagGGC ATGtttttctgtttcttTCATACAATCTATTAAATCaaatcactagagcgggcgggag g" /listShort="spoIIM, S891" /listLong="fur" /label="upshifts" promotor_-35 complement(2120527..2120532) /Source="Nicolas_upshift_promotors" /id="U1841" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=995 /SigmaFactorBS="ccgcctagcattcatctctattgtttctttttgaaaaagGGC ATGtttttctgtttcttTCATACAATCTATTAAATCaaatcactagagcgggcgggag g" /listShort="spoIIM, S891" /listLong="fur" /label="promotor_-35" CDS complement(2120564..2120779) /gene="yqkK" /locus_tag="BSU_23540" /old_locus_tag="BSU23540" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390235.1" /db_xref="EnsemblGenomes-Gn:BSU23540" /db_xref="EnsemblGenomes-Tr:CAB14286" /db_xref="SubtiList:BG11765" /db_xref="UniProtKB/Swiss-Prot:P54573" /translation="MAKSQAKKKRGHRLRNGGRDVLLSRGSTPSFSTHGRMTKSKKEI LNKRKHKNPYDHTAVDDKDFFVPQKAA*" /label="yqkK CDS" gene complement(2120564..2120779) /gene="yqkK" /locus_tag="BSU_23540" /old_locus_tag="BSU23540" /label="yqkK gene" downshifts complement(2120644) /Source="Nicolas_upshifts" /id="D1228" /incds=1 /nref=17 /ntot=130 /MaxReadThrough="0.857610000000001" /MaxDrop="3.7055" /score="1.77181315" /energy="-9.8" /TU="NA" /idTUdmin="U1842" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2120879..2122198) /gene="mleA" /locus_tag="BSU_23550" /old_locus_tag="BSU23550" /EC_number="1.1.1.38" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16788182, 23136871" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16788182, 23136871; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="catabolic NAD-dependent malic enzyme (conversionof malate into pyruvate)" /protein_id="NP_390236.1" /db_xref="EnsemblGenomes-Gn:BSU23550" /db_xref="EnsemblGenomes-Tr:CAB14287" /db_xref="GOA:P54572" /db_xref="InterPro:IPR001891" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR006140" /db_xref="InterPro:IPR012301" /db_xref="InterPro:IPR012302" /db_xref="InterPro:IPR015884" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR037062" /db_xref="SubtiList:BG11764" /db_xref="UniProtKB/Swiss-Prot:P54572" /translation="MIAKHMIRTLMIETPSVPGNLGRVATAIGLLGGDIGEVETVKVG PNYTMRNITVQVENEEQLQEVIAAVQALGEGIRLHTVSDEVLSAHEGGKIQMKSKMPI RSLAELGRVYTPGVADVCRLIEKEPEKASIYTTISNSVAIVTDGTAILGLGNIGSVAG MPVMEGKAALFDQLAGISGIPILLDTSDPEEIIKTVKHISPGFSGILLEDIGSPHCFE IEDRLKEELNIPVMHDDQHGTAVVTLAAAISACRSAGVDLKEAKVGQIGLGAAGVAIC RMFMAYGVNAVYGTDKSESAMNRLEQYGGQAVSSIEELMETCDIVIATTGVPGLIKPA FVRSGQVILALSNPKPEIEPEAALQAGAAYAADGRSVNNVLGFPGIFRGALNAKSTEI NHDMLVAAAEAIAACTKQGDVVPQPLDSKVHHAVAAAVEHAALTAVK*" /label="mleA CDS" gene complement(2120879..2122198) /gene="mleA" /locus_tag="BSU_23550" /old_locus_tag="BSU23550" /label="mleA gene" downshifts complement(2120886) /Source="Nicolas_upshifts" /id="D1229" /incds=0 /nref=29 /ntot=84 /MaxReadThrough="3.50516" /MaxDrop="5.65279" /score="42.1653011" /energy="-15.2" /TU="U1842,U1843" /idTUdmin="U1842" /TUdmin="-243" /isTUend="FALSE" /label="downshifts" CDS complement(2122216..2123622) /gene="mleN" /locus_tag="BSU_23560" /old_locus_tag="BSU23560" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10903309, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10903309, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="malate-H+/Na+-lactate antiporter" /protein_id="NP_390237.1" /db_xref="EnsemblGenomes-Gn:BSU23560" /db_xref="EnsemblGenomes-Tr:CAB14288" /db_xref="GOA:P54571" /db_xref="InterPro:IPR004770" /db_xref="InterPro:IPR018461" /db_xref="SubtiList:BG11763" /db_xref="UniProtKB/Swiss-Prot:P54571" /translation="MKDVRLPTLFEIIIVLGVFLALVLSFTVFLDLPIQLALFVSWFI AMLLGIRLGYSYKDLQNAIVHGISNGLEAVLILVSVGALIGTWIAGGVVPTLIYYGLE FIHPSIFLLATLIICSIMSVATGTSWGTVGTAGIAMIAIGEGLGIPLPLVAGAILSGA YFGDKLSPLSDSTVLASSLSKVDVLAHVRAMLYLSIPAYVITAILFTVVGFMYGGKNI DLDKVEFLKSSLQNTFDIHIWMLIPAVLVIVLLAMKKPSMPVIVIGALLGAIWAVVFQ GMDIAHAIATAYNGFSIKTDVEFLNGLLNRGGIVGMLDSLVVIIFGLGFGGLLEKLGV LKVIVSTFEKKLTSAGNVTLSTLIVAFLANIFGCAMYVSLILTPKIMEDSYDRLHLDR RVLSRNSEVGGTLTSGMVPWSDNGIYMAGILGVSTFSYLPFMWLSFVAIGLAIIYGYT GKFIWYTKNNTVKAEKLG*" /label="mleN CDS" gene complement(2122216..2123622) /gene="mleN" /locus_tag="BSU_23560" /old_locus_tag="BSU23560" /label="mleN gene" promotor_-10 complement(2123670..2123689) /Source="Nicolas_upshift_promotors" /id="U1842" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.964035964035964" /psig="0.998001998001998" /xcortree=2714 /SigmaFactorBS="tcatctccgaatagtcggatgaataagcTGTTTACAacatag ggatgaggAAGTATAGTATACGTGTTGCactatatattgaaagcgttttagcttttac a" /listShort="mleN, mleA, yqkK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2123679) /Source="Nicolas_upshifts" /id="U1842" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.964035964035964" /psig="0.998001998001998" /xcortree=2714 /SigmaFactorBS="tcatctccgaatagtcggatgaataagcTGTTTACAacatag ggatgaggAAGTATAGTATACGTGTTGCactatatattgaaagcgttttagcttttac a" /listShort="mleN, mleA, yqkK" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2123681..2123762) /Source="Nicolas_S_feature" /locus_tag="new_2454265_2454346_c" /HighExp="S0, dia0, dia5, Lbexp, G150, Oxctl, G135, Mt0, Paraq, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.937" /TUlongSig="NA" /TUlongPSig="NA" /label="S892" promotor_-35 complement(2123704..2123711) /Source="Nicolas_upshift_promotors" /id="U1842" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.964035964035964" /psig="0.998001998001998" /xcortree=2714 /SigmaFactorBS="tcatctccgaatagtcggatgaataagcTGTTTACAacatag ggatgaggAAGTATAGTATACGTGTTGCactatatattgaaagcgttttagcttttac a" /listShort="mleN, mleA, yqkK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2123763..2125190) /gene="ansB" /locus_tag="BSU_23570" /old_locus_tag="BSU23570" /EC_number="4.3.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1711029" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1711029; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="L-aspartase (aspartate ammonia lyase)" /protein_id="NP_390238.2" /db_xref="EnsemblGenomes-Gn:BSU23570" /db_xref="EnsemblGenomes-Tr:CAB14289" /db_xref="GOA:P26899" /db_xref="InterPro:IPR000362" /db_xref="InterPro:IPR004708" /db_xref="InterPro:IPR008948" /db_xref="InterPro:IPR018951" /db_xref="InterPro:IPR020557" /db_xref="InterPro:IPR022761" /db_xref="InterPro:IPR024083" /db_xref="SubtiList:BG10301" /db_xref="UniProtKB/Swiss-Prot:P26899" /translation="MLNGQKEYRVEKDFLGEKQIEADVYYGIQTLRASENFPITGYKI HEEMINALAIVKKAAALANMDVKRLYEGIGQAIVQAADEILEGKWHDQFIVDPIQGGA GTSMNMNANEVIGNRALEIMGHKKGDYIHLSPNTHVNMSQSTNDVFPTAIHISTLKLL EKLLKTMEDMHSVFKQKAQEFDSVIKMGRTHLQDAVPIRLGQEFEAYSRVLERDIKRI KQSRQHLYEVNMGATAVGTGLNADPEYIKQVVKHLADISGLPLVGADHLVDATQNTDA YTEVSASLKVCMMNMSKIANDLRLMASGPRAGLAEISLPARQPGSSIMPGKVNPVMAE LINQIAFQVIGNDNTICLASEAGQLELNVMEPVLVFNLLQSISIMNNGFRSFTDNCLK GIEANEKRMKQYVEKSAGVITAVNPHLGYEAAARIAREAIMTGQSVRDLCLQHDVLTE EELDIILNPYEMTKPGIAGKELLEK*" /label="ansB CDS" gene complement(2123763..2125190) /gene="ansB" /locus_tag="BSU_23570" /old_locus_tag="BSU23570" /label="ansB gene" CDS complement(2125235..2126224) /gene="ansA" /locus_tag="BSU_23580" /old_locus_tag="BSU23580" /EC_number="3.5.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1711029, 11914346, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1711029, 11914346, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported L-asparaginase" /protein_id="NP_390239.1" /db_xref="EnsemblGenomes-Gn:BSU23580" /db_xref="EnsemblGenomes-Tr:CAB14290" /db_xref="GOA:P26900" /db_xref="InterPro:IPR006033" /db_xref="InterPro:IPR006034" /db_xref="InterPro:IPR020827" /db_xref="InterPro:IPR027473" /db_xref="InterPro:IPR027474" /db_xref="InterPro:IPR027475" /db_xref="InterPro:IPR036152" /db_xref="InterPro:IPR037152" /db_xref="SubtiList:BG10300" /db_xref="UniProtKB/Swiss-Prot:P26900" /translation="MKKLLMLTTGGTIASVEGENGLAPGVKADELLSYVSKLDNDYTM ETQSLMNIDSTNMQPEYWVEIAEAVKENYDAYDGFVITHGTDTMAYTSAALSYMLQHA KKPIVITGSQIPITFQKTDAKKNITDAIRFACEGVGGVYVVFDGRVIQGTRAIKLRTK SYDAFESINYPYIAFINEDGIEYNKQVTEPENDTFTVDTSLCTDVCLLKLHPGLKPEM FDALKSMYKGIVIESYGSGGVPFEGRDILSKVNELIESGIVVVITTQCLEEGEDMSIY EVGRRVNQDLIIRSRNMNTEAIVPKLMWALGQSSDLPVVKRIMETPIADDVVL*" /label="ansA CDS" gene complement(2125235..2126224) /gene="ansA" /locus_tag="BSU_23580" /old_locus_tag="BSU23580" /label="ansA gene" S_feature complement(2126225..2126304) /Source="Nicolas_S_feature" /locus_tag="new_2456809_2456888_c" /HighExp="dia0, Lbexp, G150, Oxctl, dia5, LBGexp, Paraq, C30, G180, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.937" /TUlongSig="NA" /TUlongPSig="NA" /label="S893" promotor_-10 complement(2126286..2126305) /Source="Nicolas_upshift_promotors" /id="U1843" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.808191808191808" /psig=1 /xcortree=1807 /SigmaFactorBS="taggtattaggaagtgtacgcgaattgaataataatgTCTTG CGTattttattttccgtGTCTATAATTGCATTAAAAGtatgcgaaaagcgaatacctt c" /listShort="S893, ansA, ansB, S892, mleN, mleA, yqkK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2126304) /Source="Nicolas_upshifts" /id="U1843" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.808191808191808" /psig=1 /xcortree=1807 /SigmaFactorBS="taggtattaggaagtgtacgcgaattgaataataatgTCTTG CGTattttattttccgtGTCTATAATTGCATTAAAAGtatgcgaaaagcgaatacctt c" /listShort="S893, ansA, ansB, S892, mleN, mleA, yqkK" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2126306..2126626) /Source="Nicolas_S_feature" /locus_tag="new_2456890_2457210_c" /HighExp="LBGstat, S5, G135, S8, S6, LBGtran, G180, G150, LoTm, LBGexp" /AntisenseName="ansR" /AntisenseCor="0.23077291929287899" /AntisenseRegPval="-3.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.937" /TUlongSig="NA" /TUlongPSig="NA" /label="S894" promotor_-35 complement(2126320..2126327) /Source="Nicolas_upshift_promotors" /id="U1843" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.808191808191808" /psig=1 /xcortree=1807 /SigmaFactorBS="taggtattaggaagtgtacgcgaattgaataataatgTCTTG CGTattttattttccgtGTCTATAATTGCATTAAAAGtatgcgaaaagcgaatacctt c" /listShort="S893, ansA, ansB, S892, mleN, mleA, yqkK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2126345..2126352 /Source="Nicolas_upshift_promotors" /id="U1844" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.525474525474525" /psig="0.998001998001998" /xcortree=2183 /SigmaFactorBS="cggaaaataaaatacgcaagacattattattcaattcgCGTA CACTtcctaatacctaTATGATATAATCAGCTCAAGgtgaaaaaggagcggaagttca t" /listShort="ansR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2126365..2126384 /Source="Nicolas_upshift_promotors" /id="U1844" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.525474525474525" /psig="0.998001998001998" /xcortree=2183 /SigmaFactorBS="cggaaaataaaatacgcaagacattattattcaattcgCGTA CACTtcctaatacctaTATGATATAATCAGCTCAAGgtgaaaaaggagcggaagttca t" /listShort="ansR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2126367 /Source="Nicolas_upshifts" /id="U1844" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.525474525474525" /psig="0.998001998001998" /xcortree=2183 /SigmaFactorBS="cggaaaataaaatacgcaagacattattattcaattcgCGTA CACTtcctaatacctaTATGATATAATCAGCTCAAGgtgaaaaaggagcggaagttca t" /listShort="ansR" /GFF_Attribute="listLong" /label="upshifts" CDS 2126406..2126756 /gene="ansR" /locus_tag="BSU_23590" /old_locus_tag="BSU23590" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11914346" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11914346; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of ansAB (Xre family)" /protein_id="NP_390240.1" /db_xref="EnsemblGenomes-Gn:BSU23590" /db_xref="EnsemblGenomes-Tr:CAB14291" /db_xref="GOA:Q07683" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR027910" /db_xref="SubtiList:BG10299" /db_xref="UniProtKB/Swiss-Prot:Q07683" /translation="MNLDRLTELRKKKNWSLQYTADLLGIAKSTYAGYESGYRRPSLE ALAMLADLFDTTCDELLGREKQKQTAPQAIELATWSSLDFTISVDGQPLSEDEIIQLI TFIRTKRKVQEELS*" /label="ansR CDS" gene 2126406..2126756 /gene="ansR" /locus_tag="BSU_23590" /old_locus_tag="BSU23590" /label="ansR gene" S_feature complement(2126628..2126764) /Source="Nicolas_S_feature" /locus_tag="new_2457212_2457348_c" /HighExp="LBGstat, S8, S6, S7, S5, ferm, nit, LBGtran, BT, LPhT" /AntisenseName="ansR" /AntisenseCor="-0.22421651781702501" /AntisenseRegPval="-3.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.937" /TUlongSig="NA" /TUlongPSig="NA" /label="S895" downshifts complement(2126671) /Source="Nicolas_upshifts" /id="D1230" /incds=1 /nref=4 /ntot=116 /MaxReadThrough="3.90926" /MaxDrop="4.76642" /score="10.2434094" /energy="-23.6" /TU="U1847" /idTUdmin="U1845" /TUdmin=1451 /isTUend="FALSE" /label="downshifts" CDS complement(2126765..2127928) /gene="yqxK" /locus_tag="BSU_23600" /old_locus_tag="BSU23600" /function="16.11: Scavenge (Catabolism)" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative nucleotide binding protein" /protein_id="NP_390241.2" /db_xref="EnsemblGenomes-Gn:BSU23600" /db_xref="EnsemblGenomes-Tr:CAB14292" /db_xref="GOA:P38423" /db_xref="InterPro:IPR005287" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR016195" /db_xref="SubtiList:BG11073" /db_xref="UniProtKB/Swiss-Prot:P38423" /translation="MKKIYADLHIHIGRTFTGRAVKITGAKTLTLDRILVEASEHKGI ELLGIIDCHSPEVILELEEGISSGKYRELDGGGIRYRSTTLLLGSELEIYDEACSGPI HVLVFMPTLADMKQFSNWLSARLKNIHLSSQRIYETGLNLQKKVQDMGGLFIPAHIFT PHKSLYGKGVKSSLTEVFDPSMIDAVELGLSCDTDMASHVSQLNPYPFLTNSDAHSLG KIGREYNELYVQSADFTEFALALKGQDDRKIIANYGLDPLLGKYYQTACEACGEPAVS GETACANCGKARFTKGVSDRLRELSDQLEVRVPRPRYVHQIPLQFVPGVGPKTLDKLK KAFGTEMAVLHEAAEEDLARVVPPKTAALIVKARSGKLELKAGGGGTYGKIKP*" /label="yqxK CDS" gene complement(2126765..2127928) /gene="yqxK" /locus_tag="BSU_23600" /old_locus_tag="BSU23600" /label="yqxK gene" CDS complement(2127925..2128482) /gene="nudF" /locus_tag="BSU_23610" /old_locus_tag="BSU23610" /EC_number="3.1.7.1" /EC_number="3.6.1.13" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10542272, 17693564, 21638333, 25212876; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isopentenyl pyrophosphate and dimethylallyl pyrophosphate diphosphatase (moonlighting ADP-ribose pyrophosphatase)" /protein_id="NP_390242.1" /db_xref="EnsemblGenomes-Gn:BSU23610" /db_xref="EnsemblGenomes-Tr:CAB14293" /db_xref="GOA:P54570" /db_xref="InterPro:IPR000086" /db_xref="InterPro:IPR015797" /db_xref="InterPro:IPR020084" /db_xref="InterPro:IPR020476" /db_xref="SubtiList:BG11762" /db_xref="UniProtKB/Swiss-Prot:P54570" /translation="MKSLEEKTIAKEQIFSGKVIDLYVEDVELPNGKASKREIVKHPG AVAVLAVTDEGKIIMVKQFRKPLERTIVEIPAGKLEKGEEPEYTALRELEEETGYTAK KLTKITAFYTSPGFADEIVHVFLAEELSVLEEKRELDEDEFVEVMEVTLEDALKLVES REVYDAKTAYAIQYLQLKEALQAQK*" /label="nudF CDS" gene complement(2127925..2128482) /gene="nudF" /locus_tag="BSU_23610" /old_locus_tag="BSU23610" /label="nudF gene" promotor_no_box complement(2128412..2128512) /Source="Nicolas_upshift_promotors" /id="U1845" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.688311688311688" /psig="0.01998001998002" /xcortree=1733 /SigmaFactorBS="tcatatagagacagaacgggagatgaagaaatgaaatcatta gaagaaaaaacaattgccaaagaacagattttttcgggtaaagtcattgatctttatg t" /listShort="nudF" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(2128452) /Source="Nicolas_upshifts" /id="U1845" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.688311688311688" /psig="0.01998001998002" /xcortree=1733 /SigmaFactorBS="tcatatagagacagaacgggagatgaagaaatgaaatcatta gaagaaaaaacaattgccaaagaacagattttttcgggtaaagtcattgatctttatg t" /listShort="nudF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2128496..2128501 /Source="Nicolas_upshift_promotors" /id="U1846" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1028 /SigmaFactorBS="ttttcttctaatgatttcatttcttcatctcccGTTCTGtct ctatatgatgccCCATACATTTTATCATACTagagcaaaagggggcttcttcgtgaaa g" /listShort="S896, yqkF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2128517..2128535 /Source="Nicolas_upshift_promotors" /id="U1846" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1028 /SigmaFactorBS="ttttcttctaatgatttcatttcttcatctcccGTTCTGtct ctatatgatgccCCATACATTTTATCATACTagagcaaaagggggcttcttcgtgaaa g" /listShort="S896, yqkF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2128519..2128533) /Source="Nicolas_upshift_promotors" /id="U1847" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.404595404595405" /psig="0.937062937062937" /xcortree=2733 /SigmaFactorBS="tccgactaagacaacaccttttggcatgcggtgcactttcac gaagaagcccccttttgcTCTAgTATGATAAAATGTATggggcatcatatagagacag a" /listShort="nudF, yqxK, S895, S894, S893, ansA, ansB, S892" /listLong="mleN, mleA, yqkK" /label="promotor_-10" upshifts 2128523 /Source="Nicolas_upshifts" /id="U1846" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1028 /SigmaFactorBS="ttttcttctaatgatttcatttcttcatctcccGTTCTGtct ctatatgatgccCCATACATTTTATCATACTagagcaaaagggggcttcttcgtgaaa g" /listShort="S896, yqkF" /GFF_Attribute="listLong" /label="upshifts" S_feature 2128530..2128704 /Source="Nicolas_S_feature" /locus_tag="new_2459114_2459288" /HighExp="S4, S5, S3, S7, S6, LoTm, BT, T5.0H, G/S, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99962399999999996" /TUshortSig="SigEF" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S896" promotor_-35 complement(2128535..2128538) /Source="Nicolas_upshift_promotors" /id="U1847" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.404595404595405" /psig="0.937062937062937" /xcortree=2733 /SigmaFactorBS="tccgactaagacaacaccttttggcatgcggtgcactttcac gaagaagcccccttttgcTCTAgTATGATAAAATGTATggggcatcatatagagacag a" /listShort="nudF, yqxK, S895, S894, S893, ansA, ansB, S892" /listLong="mleN, mleA, yqkK" /label="promotor_-35" upshifts complement(2128538) /Source="Nicolas_upshifts" /id="U1847" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.404595404595405" /psig="0.937062937062937" /xcortree=2733 /SigmaFactorBS="tccgactaagacaacaccttttggcatgcggtgcactttcac gaagaagcccccttttgcTCTAgTATGATAAAATGTATggggcatcatatagagacag a" /listShort="nudF, yqxK, S895, S894, S893, ansA, ansB, S892" /listLong="mleN, mleA, yqkK" /label="upshifts" CDS 2128557..2128679 /gene="mciZ" /locus_tag="BSU_23616" /old_locus_tag="BSU23616" /function="15.1: Cell division" /experiment="publication(s) with functional evidences, PMID:18284588, 23237472, 25848052, 27752253" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18284588, 23237472, 25848052, 27752253; Product type f: factor" /codon_start=1 /transl_table=11 /product="cell division inhibitor" /protein_id="YP_009513976.1" /db_xref="EnsemblGenomes-Gn:BSU23616" /db_xref="EnsemblGenomes-Tr:CCQ48600" /db_xref="GOA:L8EBJ9" /db_xref="InterPro:IPR025177" /db_xref="PDB:2MRW" /db_xref="PDB:4U39" /db_xref="UniProtKB/TrEMBL:L8EBJ9" /translation="MKVHRMPKGVVLVGKAWEIRAKLKEYGRTFQYVKDWISKP*" /label="mciZ CDS" gene 2128557..2128679 /gene="mciZ" /locus_tag="BSU_23616" /old_locus_tag="BSU23616" /label="mciZ gene" promotor_-35 2128680..2128687 /Source="Nicolas_upshift_promotors" /id="U1848" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.717282717282717" /psig="0.998001998001998" /xcortree=1920 /SigmaFactorBS="tcaatatgtgaaagattggatctcaaagccataaAAGTTGAA actttagctccttTATATTACGGTCAATACAAAgcctaaaaaaggagtgtgcacatga g" /listShort="yqkF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2128701..2128720 /Source="Nicolas_upshift_promotors" /id="U1848" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.717282717282717" /psig="0.998001998001998" /xcortree=1920 /SigmaFactorBS="tcaatatgtgaaagattggatctcaaagccataaAAGTTGAA actttagctccttTATATTACGGTCAATACAAAgcctaaaaaaggagtgtgcacatga g" /listShort="yqkF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2128706 /Source="Nicolas_upshifts" /id="U1848" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.717282717282717" /psig="0.998001998001998" /xcortree=1920 /SigmaFactorBS="tcaatatgtgaaagattggatctcaaagccataaAAGTTGAA actttagctccttTATATTACGGTCAATACAAAgcctaaaaaaggagtgtgcacatga g" /listShort="yqkF" /GFF_Attribute="listLong" /label="upshifts" CDS 2128742..2129662 /gene="yqkF" /locus_tag="BSU_23620" /old_locus_tag="BSU23620" /EC_number="1.1.1.-" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 9643546, 15317791, 16242712, 24330391; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADPH-dependent aldo-keto reductase (acts on 4-hydroxy-2,3-trans-nonenal)" /protein_id="NP_390243.1" /db_xref="EnsemblGenomes-Gn:BSU23620" /db_xref="EnsemblGenomes-Tr:CAB14294" /db_xref="GOA:P54569" /db_xref="InterPro:IPR020471" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="SubtiList:BG11761" /db_xref="UniProtKB/Swiss-Prot:P54569" /translation="MRKRKLGTSDLDISEVGLGCMSLGTEKNKALSILDEAIELGINY LDTADLYDRGRNEEIVGDAIQNRRHDIILATKAGNRWDDGSEGWYWDPSKAYIKEAVK KSLTRLKTDYIDLYQLHGGTIEDNIDETIEAFEELKQEGVIRYYGISSIRPNVIKEYV KKSNIVSIMMQFSLFDRRPEEWLPLLEEHQISVVARGPVAKGLLTEKPLDQASESMKQ NGYLSYSFEELTNARKAMEEVAPDLSMTEKSLQYLLAQPAVASVITGASKIEQLRENI QAANARRLTEEEIKALQSHTKQDIYKAHRS*" /label="yqkF CDS" gene 2128742..2129662 /gene="yqkF" /locus_tag="BSU_23620" /old_locus_tag="BSU23620" /label="yqkF gene" downshifts 2129651 /Source="Nicolas_upshifts" /id="D1231" /incds=0 /nref=186 /ntot=248 /MaxReadThrough="1.49159" /MaxDrop="5.81013" /score="18.6018806" /energy="-14.8" /TU="NA" /idTUdmin="U1846" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2129694..2129918) /gene="yqkE" /locus_tag="BSU_23630" /old_locus_tag="BSU23630" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390244.1" /db_xref="EnsemblGenomes-Gn:BSU23630" /db_xref="EnsemblGenomes-Tr:CAB14295" /db_xref="InterPro:IPR024980" /db_xref="SubtiList:BG11760" /db_xref="UniProtKB/Swiss-Prot:P54568" /translation="MKKQKSIDKHQLKDGLQSDIKAKLMEMKSQLKEEDEKRQKREKA EQIRKKKEIEKNKSFEELLNESQMDWHQYK*" /label="yqkE CDS" gene complement(2129694..2129918) /gene="yqkE" /locus_tag="BSU_23630" /old_locus_tag="BSU23630" /label="yqkE gene" downshifts complement(2129751) /Source="Nicolas_upshifts" /id="D1232" /incds=0 /nref=19 /ntot=195 /MaxReadThrough="0.59953" /MaxDrop="5.9087" /score="15.8160537" /energy="-13" /TU="NA" /idTUdmin="U1849" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2129941..2129960) /Source="Nicolas_upshift_promotors" /id="U1849" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.718281718281718" /psig="0.996003996003996" /xcortree=2028 /SigmaFactorBS="gctgagaaagtgatcagaagagagtcTGCTTGTTcagtttat atgctcCGTGATAAACTGGCTTCAAAacaaaacatgggggaagtctgcatgaaaaaac a" /listShort="yqkE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2129948) /Source="Nicolas_upshifts" /id="U1849" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.718281718281718" /psig="0.996003996003996" /xcortree=2028 /SigmaFactorBS="gctgagaaagtgatcagaagagagtcTGCTTGTTcagtttat atgctcCGTGATAAACTGGCTTCAAAacaaaacatgggggaagtctgcatgaaaaaac a" /listShort="yqkE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2129975..2129982) /Source="Nicolas_upshift_promotors" /id="U1849" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.718281718281718" /psig="0.996003996003996" /xcortree=2028 /SigmaFactorBS="gctgagaaagtgatcagaagagagtcTGCTTGTTcagtttat atgctcCGTGATAAACTGGCTTCAAAacaaaacatgggggaagtctgcatgaaaaaac a" /listShort="yqkE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2129997..2130004 /Source="Nicolas_upshift_promotors" /id="U1850" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.7002997002997" /psig=1 /xcortree=3151 /SigmaFactorBS="tataaactgaacaagcagactctcttctgatCACTTTCTcag cgtagcagtgtTTAGGTATAATGATCTTAAAcacgaattgcctatatatttcgttgaa a" /listShort="yqkD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2130019..2130038 /Source="Nicolas_upshift_promotors" /id="U1850" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.7002997002997" /psig=1 /xcortree=3151 /SigmaFactorBS="tataaactgaacaagcagactctcttctgatCACTTTCTcag cgtagcagtgtTTAGGTATAATGATCTTAAAcacgaattgcctatatatttcgttgaa a" /listShort="yqkD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2130026 /Source="Nicolas_upshifts" /id="U1850" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.7002997002997" /psig=1 /xcortree=3151 /SigmaFactorBS="tataaactgaacaagcagactctcttctgatCACTTTCTcag cgtagcagtgtTTAGGTATAATGATCTTAAAcacgaattgcctatatatttcgttgaa a" /listShort="yqkD" /GFF_Attribute="listLong" /label="upshifts" CDS 2130080..2130997 /gene="yqkD" /locus_tag="BSU_23640" /old_locus_tag="BSU23640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390245.1" /db_xref="EnsemblGenomes-Gn:BSU23640" /db_xref="EnsemblGenomes-Tr:CAB14296" /db_xref="GOA:P54567" /db_xref="InterPro:IPR022742" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG11759" /db_xref="UniProtKB/Swiss-Prot:P54567" /translation="MKKILLAIGALVTAVIAIGIVFSHMILFIKKKTDEDIIKRETDN GHDVFESFEQMEKTAFVIPSAYGYDIKGYHVAPHDTPNTIIICHGVTMNVLNSLKYMH LFLDLGWNVLIYDHRRHGQSGGKTTSYGFYEKDDLNKVVSLLKNKTNHRGLIGIHGES MGAVTALLYAGAHCSDGADFYIADCPFACFDEQLAYRLRAEYRLPSWPLLPIADFFLK LRGGYRAREVSPLAVIDKIEKPVLFIHSKDDDYIPVSSTERLYEKKRGPKALYIAENG EHAMSYTKNRHTYRKTVQEFLDNMNDSTE*" /label="yqkD CDS" gene 2130080..2130997 /gene="yqkD" /locus_tag="BSU_23640" /old_locus_tag="BSU23640" /label="yqkD gene" downshifts 2130972 /Source="Nicolas_upshifts" /id="D1233" /incds=0 /nref=27 /ntot=171 /MaxReadThrough="2.02201" /MaxDrop="3.99393" /score="14.106821" /energy="-11.8" /TU="NA" /idTUdmin="U1850" /TUdmin=594 /isTUend="FALSE" /label="downshifts" CDS complement(2131037..2131276) /gene="yqkC" /locus_tag="BSU_23650" /old_locus_tag="BSU23650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390246.1" /db_xref="EnsemblGenomes-Gn:BSU23650" /db_xref="EnsemblGenomes-Tr:CAB14297" /db_xref="InterPro:IPR020157" /db_xref="SubtiList:BG11758" /db_xref="UniProtKB/Swiss-Prot:P54566" /translation="MEQKLKAMKNTAQNKTWVSFLNQNHPYTLLHWSIGGAESIKKDV WLLQDEMTFETQEFTTIDLAIEWIRENMDGITDVL*" /label="yqkC CDS" gene complement(2131037..2131276) /gene="yqkC" /locus_tag="BSU_23650" /old_locus_tag="BSU23650" /label="yqkC gene" downshifts complement(2131048) /Source="Nicolas_upshifts" /id="D1234" /incds=0 /nref=215 /ntot=269 /MaxReadThrough="3.31829" /MaxDrop="6.35785" /score="16.3526162" /energy="-11.2" /TU="NA" /idTUdmin="U1851" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2131289..2131612) /gene="yqkB" /locus_tag="BSU_23660" /old_locus_tag="BSU23660" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390247.1" /db_xref="EnsemblGenomes-Gn:BSU23660" /db_xref="EnsemblGenomes-Tr:CAB14298" /db_xref="InterPro:IPR000361" /db_xref="InterPro:IPR035903" /db_xref="SubtiList:BG11757" /db_xref="UniProtKB/Swiss-Prot:P54565" /translation="MNIHVTDAAKQALQQAFDANPGKKAQLRYDAEGCGCAVSGVPTI WLAEELTGQCEQLETNGIPLYIQSSQKVFFDDQMTIDYNEKAKTLALKSPAEMLSPRM SILVK*" /label="yqkB CDS" gene complement(2131289..2131612) /gene="yqkB" /locus_tag="BSU_23660" /old_locus_tag="BSU23660" /label="yqkB gene" promotor_-10 complement(2131355..2131374) /Source="Nicolas_upshift_promotors" /id="U1851" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig=1 /xcortree=2731 /SigmaFactorBS="tccaatcgtcgcaaaaagtgtTTTTTGACgatcaaatgacga TCGATTACAATGAAAAAGCCaaaacattggcgctgaaaagcccggctgaaatgctcag c" /listShort="yqkC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2131356) /Source="Nicolas_upshifts" /id="U1851" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig=1 /xcortree=2731 /SigmaFactorBS="tccaatcgtcgcaaaaagtgtTTTTTGACgatcaaatgacga TCGATTACAATGAAAAAGCCaaaacattggcgctgaaaagcccggctgaaatgctcag c" /listShort="yqkC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2131388..2131395) /Source="Nicolas_upshift_promotors" /id="U1851" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig=1 /xcortree=2731 /SigmaFactorBS="tccaatcgtcgcaaaaagtgtTTTTTGACgatcaaatgacga TCGATTACAATGAAAAAGCCaaaacattggcgctgaaaagcccggctgaaatgctcag c" /listShort="yqkC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2131609..2132640) /gene="yqkA" /locus_tag="BSU_23670" /old_locus_tag="BSU23670" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390248.1" /db_xref="EnsemblGenomes-Gn:BSU23670" /db_xref="EnsemblGenomes-Tr:CAB14299" /db_xref="GOA:P54564" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR007344" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11756" /db_xref="UniProtKB/Swiss-Prot:P54564" /translation="MIEFLQHKEATIAREILAVQIPAYIKETEIIGFDGIPALQEKVK DIQASHERFAGYRKNGKLIGVISYEKNMHYLTICRLVVHPDGFRKGIGRALLQFVIDH NEDAEKIEVVTAENNTPAVSLYTQAGFQKAETVKAAQGLLLSVFHLYPKRKVEIILYN EKWAECFDEEKERLKLVFGPEIIAIHHIGSTSIPNMAAKPIIDMLIEVRSIEAVSQFD EQMKANGYTPKGENGIAGRRYFQKGGNKRTHHVHMYEQGNPAIERHLLFRDYLRAHPN IAKEYAVLKKQLAAQHPDSINQYIQGKDEWIKTAEENAKRWKKGRNNANGSIVCYNSE NDENGGFTL*" /label="yqkA CDS" gene complement(2131609..2132640) /gene="yqkA" /locus_tag="BSU_23670" /old_locus_tag="BSU23670" /label="yqkA gene" promotor_-10 complement(2131636..2131655) /Source="Nicolas_upshift_promotors" /id="U1852" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=2060 /SigmaFactorBS="atgcgaagcggtggaaaaaaggcagaaacaATGCGAATggca gtattgTATGCTACAATAGCGAAAATgatgaaaacgggggtttcaccttatgaacata c" /listShort="yqkB, yqkC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2131643) /Source="Nicolas_upshifts" /id="U1852" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=2060 /SigmaFactorBS="atgcgaagcggtggaaaaaaggcagaaacaATGCGAATggca gtattgTATGCTACAATAGCGAAAATgatgaaaacgggggtttcaccttatgaacata c" /listShort="yqkB, yqkC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2131666..2131673) /Source="Nicolas_upshift_promotors" /id="U1852" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=2060 /SigmaFactorBS="atgcgaagcggtggaaaaaaggcagaaacaATGCGAATggca gtattgTATGCTACAATAGCGAAAATgatgaaaacgggggtttcaccttatgaacata c" /listShort="yqkB, yqkC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2132633..2132977) /gene="yqjZ" /locus_tag="BSU_23680" /old_locus_tag="BSU23680" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative degradation enzyme (oxygenase)" /protein_id="NP_390249.1" /db_xref="EnsemblGenomes-Gn:BSU23680" /db_xref="EnsemblGenomes-Tr:CAB14300" /db_xref="InterPro:IPR007138" /db_xref="InterPro:IPR011008" /db_xref="PDB:2GO8" /db_xref="SubtiList:BG11755" /db_xref="UniProtKB/Swiss-Prot:P54563" /translation="MMDFLSKTPEPPYYAVIFSSVKSENDTGYGETAERMVSLAADQP GFLGVESVREADGRGITVSYWDSMDAINHWRHHTEHQAAKEKGRSVWYESYAVRVAKV DRQRLFQENTND*" /label="yqjZ CDS" gene complement(2132633..2132977) /gene="yqjZ" /locus_tag="BSU_23680" /old_locus_tag="BSU23680" /label="yqjZ gene" CDS complement(2132987..2133457) /gene="yqjY" /locus_tag="BSU_23690" /old_locus_tag="BSU23690" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_390250.1" /db_xref="EnsemblGenomes-Gn:BSU23690" /db_xref="EnsemblGenomes-Tr:CAB14301" /db_xref="GOA:P54562" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR017255" /db_xref="PDB:1MK4" /db_xref="SubtiList:BG11754" /db_xref="UniProtKB/Swiss-Prot:P54562" /translation="MDIRTITSSDYEMVTSVLNEWWGGRQLKEKLPRLFFEHFQDTSF ITSEHNSMTGFLIGFQSQSDPETAYIHFSGVHPDFRKMQIGKQLYDVFIETVKQRGCT RVKCVTSPVNKVSIAYHTKLGFDIEKGTKTVNGISVFANYDGPGQDRVLFVKNI*" /label="yqjY CDS" gene complement(2132987..2133457) /gene="yqjY" /locus_tag="BSU_23690" /old_locus_tag="BSU23690" /label="yqjY gene" S_feature complement(2133458..2133534) /Source="Nicolas_S_feature" /locus_tag="new_2464042_2464118_c" /HighExp="SMM, T-4.40H, MG 150, M9-tran, GM 90, T-3.40H, GM-0.2, M9-exp, GM 120, T-2.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigEF" /TUlongPSig="0.776" /label="S897" downshifts 2133458 /Source="Nicolas_upshifts" /id="D1235" /incds=0 /nref=8 /ntot=121 /MaxReadThrough="0.87367" /MaxDrop="3.61005" /score="-1.04904304" /energy="-6.5" /TU="NA" /idTUdmin="U1854" /TUdmin="-748" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2133509..2133528) /Source="Nicolas_upshift_promotors" /id="U1853" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig="0.999000999001" /xcortree=3045 /SigmaFactorBS="ttgttccctcggcagtctggaaacgtatgatacaggaaagaa ggCATTTACAattccagccaggcaAAATATAATTTTTATATTGTgagaaaaagagctg a" /listShort="S897, yqjY, yqjZ, yqkA, yqkB, yqkC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2133534) /Source="Nicolas_upshifts" /id="U1853" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig="0.999000999001" /xcortree=3045 /SigmaFactorBS="ttgttccctcggcagtctggaaacgtatgatacaggaaagaa ggCATTTACAattccagccaggcaAAATATAATTTTTATATTGTgagaaaaagagctg a" /listShort="S897, yqjY, yqjZ, yqkA, yqkB, yqkC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2133536..2133642) /Source="Nicolas_S_feature" /locus_tag="new_2464120_2464226_c" /HighExp="M40t90, S4, M40t45, S6, H2O2, S5, S3, S8, S7, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.776" /TUlongSig="NA" /TUlongPSig="NA" /label="S898" promotor_-35 complement(2133543..2133550) /Source="Nicolas_upshift_promotors" /id="U1853" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig="0.999000999001" /xcortree=3045 /SigmaFactorBS="ttgttccctcggcagtctggaaacgtatgatacaggaaagaa ggCATTTACAattccagccaggcaAAATATAATTTTTATATTGTgagaaaaagagctg a" /listShort="S897, yqjY, yqjZ, yqkA, yqkB, yqkC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2133643..2133981) /gene="yqjX" /locus_tag="BSU_23700" /old_locus_tag="BSU23700" /function="16.8: Protect" /function="16.5: Explore" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12137951, 16267290" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390251.1" /db_xref="EnsemblGenomes-Gn:BSU23700" /db_xref="EnsemblGenomes-Tr:CAB14302" /db_xref="GOA:P54561" /db_xref="InterPro:IPR014962" /db_xref="SubtiList:BG11753" /db_xref="UniProtKB/Swiss-Prot:P54561" /translation="MNDHLKRGNLLWEGSRMFLPEHKQSLLERKRLKQKLQKPILDPD KLEEMNQTLCAAMEFAQDITVSCFQDGEIVCCTGKICRYEEFEKAVWIKGDEDQLYKL KLDQVLDIVL*" /label="yqjX CDS" gene complement(2133643..2133981) /gene="yqjX" /locus_tag="BSU_23700" /old_locus_tag="BSU23700" /label="yqjX gene" CDS complement(2133978..2135216) /gene="polYB" /locus_tag="BSU_23710" /old_locus_tag="BSU23710" /EC_number="2.7.7.7" /function="16.5: Explore" /function="16.9: Replicate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12137951, 12644484, 15469515, 16045613, 16267290, 19924481, 24118570" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12137951, 12644484, 15469515, 16045613, 16267290, 19924481, 24118570; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Y family DNA polymerase V bypassing lesions during replication" /protein_id="NP_390252.1" /db_xref="EnsemblGenomes-Gn:BSU23710" /db_xref="EnsemblGenomes-Tr:CAB14303" /db_xref="GOA:P54560" /db_xref="InterPro:IPR001126" /db_xref="InterPro:IPR017961" /db_xref="InterPro:IPR022880" /db_xref="InterPro:IPR036775" /db_xref="SubtiList:BG11752" /db_xref="UniProtKB/Swiss-Prot:P54560" /translation="MMKEKVIFLVDMQSFYASVEKAENPHLKNRPVIVSGDPEKRGGV VLAACPLAKQKGVVNASRLWEAQEKCPEAVVLRPRMQRYIDVSLQITAILEEYTDLVE PYSIDEQFMDITGSQKLFGTPMEIAKSIQGRIMREIGVYARVGIGPNKALAKIACDNF AKKNKNGIFTLTKENMKTEMWPLPVGSMFGVGSRMKHHLNRMGISTIGGLAAFPLDLL KKKWGINGHVLWMTANGIDYSPVSTSSLDGQKAIGHGMTLPRDYEHFDKEIKVVLLEL SEEVCRRSRNAGVMGQTVSVSCRGADFDWPTGFNRQVKLAEPTNSTQDVYEAVRRLFL TFWDGKPVRRLGVNLSQLSSDDIWQLNLFQDYAKKMSLGYVMDGIKNRFGDTAIIRAA SLTAAGQAFERAAKIGGHYK*" /label="polYB CDS" gene complement(2133978..2135216) /gene="polYB" /locus_tag="BSU_23710" /old_locus_tag="BSU23710" /label="polYB gene" misc_feature 2134140..2134141 /Source="Nicolas_upshift_promotors" /id="U1854" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95904095904096" /psig="0.005994005994006" /xcortree=20 /SigmaFactorBS="tcacatagcctaggctcattttctttgcataatcctgaaata aattgagCTgccatatgtcatcagatgagagctgagacagattgacaccgaggcggcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2134151 /Source="Nicolas_upshifts" /id="U1854" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95904095904096" /psig="0.005994005994006" /xcortree=20 /SigmaFactorBS="tcacatagcctaggctcattttctttgcataatcctgaaata aattgagCTgccatatgtcatcagatgagagctgagacagattgacaccgaggcggcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2134206 /Source="Nicolas_upshifts" /id="D1236" /incds=1 /nref=2 /ntot=2 /MaxReadThrough="-0.14995" /MaxDrop="4.86715" /score="-1.04904304" /energy="-6.5" /TU="NA" /idTUdmin="U1854" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2135241..2135259) /Source="Nicolas_upshift_promotors" /id="U1855" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.776223776223776" /psig="0.776223776223776" /xcortree=763 /SigmaFactorBS="tattttctgtcagacaagaatcatttaccAGTATAaaacgaa catactttcGCATATAATGAAAAGCGAAcataagttctttttagaggtgtgtatgatg a" /listShort="polYB, yqjX, S898" /listLong="S897, yqjY, yqjZ, yqkA, yqkB, yqkC" /label="promotor_-10" upshifts complement(2135250) /Source="Nicolas_upshifts" /id="U1855" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.776223776223776" /psig="0.776223776223776" /xcortree=763 /SigmaFactorBS="tattttctgtcagacaagaatcatttaccAGTATAaaacgaa catactttcGCATATAATGAAAAGCGAAcataagttctttttagaggtgtgtatgatg a" /listShort="polYB, yqjX, S898" /listLong="S897, yqjY, yqjZ, yqkA, yqkB, yqkC" /label="upshifts" promotor_-35 complement(2135276..2135281) /Source="Nicolas_upshift_promotors" /id="U1855" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.776223776223776" /psig="0.776223776223776" /xcortree=763 /SigmaFactorBS="tattttctgtcagacaagaatcatttaccAGTATAaaacgaa catactttcGCATATAATGAAAAGCGAAcataagttctttttagaggtgtgtatgatg a" /listShort="polYB, yqjX, S898" /listLong="S897, yqjY, yqjZ, yqkA, yqkB, yqkC" /label="promotor_-35" promotor_-35 2135321..2135324 /Source="Nicolas_upshift_promotors" /id="U1856" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=2862 /SigmaFactorBS="tgattcttgtctgacagaaaatatgatccaaggGTTTgagag aagaaaaacATTTAGTAGAATAAAAGCGAagcataaggataggagagtcatgatggag a" /listShort="yqzH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2135339..2135358 /Source="Nicolas_upshift_promotors" /id="U1856" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=2862 /SigmaFactorBS="tgattcttgtctgacagaaaatatgatccaaggGTTTgagag aagaaaaacATTTAGTAGAATAAAAGCGAagcataaggataggagagtcatgatggag a" /listShort="yqzH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2135348 /Source="Nicolas_upshifts" /id="U1856" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=2862 /SigmaFactorBS="tgattcttgtctgacagaaaatatgatccaaggGTTTgagag aagaaaaacATTTAGTAGAATAAAAGCGAagcataaggataggagagtcatgatggag a" /listShort="yqzH" /GFF_Attribute="listLong" /label="upshifts" CDS 2135382..2135588 /gene="yqzH" /locus_tag="BSU_23720" /old_locus_tag="BSU23720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390253.1" /db_xref="EnsemblGenomes-Gn:BSU23720" /db_xref="EnsemblGenomes-Tr:CAB14304" /db_xref="InterPro:IPR025546" /db_xref="SubtiList:BG13774" /db_xref="UniProtKB/Swiss-Prot:O32014" /translation="MEKFVEKMLGQALRQYGRNVAIDPLSPYEKQSLKAALQERRNEE PDEDLHAHIEDIIYDYVTNQGLFS*" /label="yqzH CDS" gene 2135382..2135588 /gene="yqzH" /locus_tag="BSU_23720" /old_locus_tag="BSU23720" /label="yqzH gene" promotor_-35 2136071..2136074 /Source="Nicolas_upshift_promotors" /id="U1857" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.676323676323676" /psig="0.782217782217782" /xcortree=1401 /SigmaFactorBS="caataacgaaatattttgaacgatctATTGgagaaggaaatt ttTTCATATATGATAGAGAAAGatcatacatacaggagagaatataattcatgaagaa a" /listShort="yqjV, yqjU" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2136089..2136108 /Source="Nicolas_upshift_promotors" /id="U1857" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.676323676323676" /psig="0.782217782217782" /xcortree=1401 /SigmaFactorBS="caataacgaaatattttgaacgatctATTGgagaaggaaatt ttTTCATATATGATAGAGAAAGatcatacatacaggagagaatataattcatgaagaa a" /listShort="yqjV, yqjU" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2136105 /Source="Nicolas_upshifts" /id="U1857" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.676323676323676" /psig="0.782217782217782" /xcortree=1401 /SigmaFactorBS="caataacgaaatattttgaacgatctATTGgagaaggaaatt ttTTCATATATGATAGAGAAAGatcatacatacaggagagaatataattcatgaagaa a" /listShort="yqjV, yqjU" /GFF_Attribute="listLong" /label="upshifts" CDS 2136137..2137369 /gene="yqjV" /locus_tag="BSU_23730" /old_locus_tag="BSU23730" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12793527, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_390254.2" /db_xref="EnsemblGenomes-Gn:BSU23730" /db_xref="EnsemblGenomes-Tr:CAB14305" /db_xref="GOA:P54559" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11751" /db_xref="UniProtKB/Swiss-Prot:P54559" /translation="MKKWKDIHPISWTIIIGTIFGRMATSMSIPFLAIYLTAVQGASA SYAGLVIAASSSVGILASFYGGYISDKFGRKNMMLVSIFGWMLVFAGFAAASNLWVFF VVNALNGLCKSLFEPASKALLSDMTEEKTRLLVFNLRYAAINIGVVFGPVLGLYFGSS QSTTPFLVPAVIYGLYGIVLALQFKKHPSLSAPAQSRNMSVREAFMVTQKDYLFTIAL VGITLCTFGYSQFSSTFPQYMAQNPLIGNGTKLYGLMLTLNAIVVLATQFPIVHFAKR FSPLCSLMLGNVMVSISMAIFTVSHGVPSIVMIVITFTIGEVLLFSMMDLYVDQIAKP GLKGTYFGAIGFSQLGNVIGPWVGGICIDLFGAGRPIYIFSVLSGITLLGLPFLAFAY RQMKMETTKHRSRLEKPL*" /label="yqjV CDS" gene 2136137..2137369 /gene="yqjV" /locus_tag="BSU_23730" /old_locus_tag="BSU23730" /label="yqjV gene" CDS 2137216..2137578 /gene="yqjU" /locus_tag="BSU_23740" /old_locus_tag="BSU23740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_390255.2" /db_xref="EnsemblGenomes-Gn:BSU23740" /db_xref="EnsemblGenomes-Tr:CAB14306" /db_xref="GOA:P54558" /db_xref="SubtiList:BG11750" /db_xref="UniProtKB/Swiss-Prot:P54558" /translation="MYRPVWRWPADLYFFCPERHYPARPAIFSVRLSANENGDHKTPF PSGKAALNKKRKRMNLSRKHEVKNMNIGDVMFQLFVFIIFAAVVFAAVTGFKYAKNRK AQLDRIEKKLNSLSEDHD*" /label="yqjU CDS" gene 2137216..2137578 /gene="yqjU" /locus_tag="BSU_23740" /old_locus_tag="BSU23740" /label="yqjU gene" S_feature complement(2137395..2137574) /Source="Nicolas_S_feature" /locus_tag="new_2467979_2468158_c" /HighExp="Sw, BC, C90, C30, M0t90, BI, Lbtran, Lbstat, M40t45, G135" /AntisenseName="yqjU" /AntisenseCor="-0.38632421151235602" /AntisenseRegPval="-10.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S899" downshifts complement(2137428) /Source="Nicolas_upshifts" /id="D1237" /incds=0 /nref=59 /ntot=226 /MaxReadThrough="1.66997" /MaxDrop="4.81479" /score="21.7095422" /energy="-11.4" /TU="NA" /idTUdmin="U1858" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2137575..2137961) /gene="yqjT" /locus_tag="BSU_23750" /old_locus_tag="BSU23750" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lyase" /protein_id="NP_390256.1" /db_xref="EnsemblGenomes-Gn:BSU23750" /db_xref="EnsemblGenomes-Tr:CAB14307" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG11749" /db_xref="UniProtKB/Swiss-Prot:P54557" /translation="MHHIELYVSDLEASRRFWGWFLKELGYKEYQKWSSGISWKKDRF YLVIVQAKEPFLEPEYHRCRVGLNHLAFHAESKLQVDQMTEKLTAKGYRVLYRDRHPF AGGDGHYAVFCEDPDRIKVELVAPSC*" /label="yqjT CDS" gene complement(2137575..2137961) /gene="yqjT" /locus_tag="BSU_23750" /old_locus_tag="BSU23750" /label="yqjT gene" CDS complement(2137965..2138924) /gene="coaA" /locus_tag="BSU_23760" /old_locus_tag="BSU23760" /EC_number="2.7.1.33" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1328157, 24784177" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1328157, 24784177; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pantothenate kinase" /protein_id="NP_390257.2" /db_xref="EnsemblGenomes-Gn:BSU23760" /db_xref="EnsemblGenomes-Tr:CAB14308" /db_xref="GOA:P54556" /db_xref="InterPro:IPR004566" /db_xref="InterPro:IPR006083" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11748" /db_xref="UniProtKB/Swiss-Prot:P54556" /translation="MKNKELNLHTLYTQHNRESWSGFGGHLSIAVSEEEAKAVEGLND YLSVEEVETIYIPLVRLLHLHVKSAAERNKHVNVFLKHPHSAKIPFIIGIAGSVAVGK STTARILQKLLSRLPDRPKVSLITTDGFLFPTAELKKKNMMSRKGFPESYDVKALLEF LNDLKSGKDSVKAPVYSHLTYDREEGVFEVVEQADIVIIEGINVLQSPTLEDDRENPR IFVSDFFDFSIYVDAEESRIFTWYLERFRLLRETAFQNPDSYFHKFKDLSDQEADEMA ASIWESVNRPNLYENILPTKFRSDLILRKGDGHKVEEVLVRRV*" /label="coaA CDS" gene complement(2137965..2138924) /gene="coaA" /locus_tag="BSU_23760" /old_locus_tag="BSU23760" /label="coaA gene" S_feature complement(2138925..2138995) /Source="Nicolas_S_feature" /locus_tag="new_2469509_2469579_c" /HighExp="LBGtran, dia15, Diami, C90, H2O2, M0t45, G135, Lbtran, HiTm, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S900" CDS complement(2138996..2140342) /gene="dsdA" /locus_tag="BSU_23770" /old_locus_tag="BSU23770" /EC_number="4.3.1.18" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7592420; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="D-serine ammonia-lyase" /protein_id="NP_390258.2" /db_xref="EnsemblGenomes-Gn:BSU23770" /db_xref="EnsemblGenomes-Tr:CAB14309" /db_xref="GOA:P54555" /db_xref="InterPro:IPR000634" /db_xref="InterPro:IPR001926" /db_xref="InterPro:IPR011780" /db_xref="InterPro:IPR036052" /db_xref="SubtiList:BG11747" /db_xref="UniProtKB/Swiss-Prot:P54555" /translation="MSVHSEVLHALLKDPFIQKLIDAEPVFWANSGKKEGPLPRADEW ATEIAEAEKRMQRFAPYIAEVFPETKGAKGIIESPLFEVQHMKGKLEAAYQQPFPGRW LLKCDHELPISGSIKARGGIYEVLKYAENLALQEGMLQETDDYRILQEERFTGFFSRY SIAVGSTGNLGLSIGIIGAALGFRVTVHMSADAKQWKKDLLRQKGVTVMEYETDYSEA VNEGRRQAEQDPFCYFIDDEHSRQLFLGYAVAASRLKTQLDCMNIKPSLETPLFVYLP CGVGGGPGGVAFGLKLLYGDDVHVFFAEPTHSPCMLLGLYSGLHEKISVQDIGLDNQT AADGLAVGRPSGFVGKLIEPLLSGCYTVEDNTLYTLLHMLAVSEDKYLEPSALAGMFG PVQLFSTEEGRRYAQKYKMEHAVHVVWGTGGSMVPKDEMAAYNRIGADLLKKRNEK*" /label="dsdA CDS" gene complement(2138996..2140342) /gene="dsdA" /locus_tag="BSU_23770" /old_locus_tag="BSU23770" /label="dsdA gene" S_feature complement(2140343..2140417) /Source="Nicolas_S_feature" /locus_tag="new_2470927_2471001_c" /HighExp="C90, LBGtran, Diami, dia15, H2O2, dia5, G150, MG 15, GM-0.2, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S901" CDS complement(2140418..2141197) /gene="yqjQ" /locus_tag="BSU_23780" /old_locus_tag="BSU23780" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metabolite dehydrogenase, NAD-binding" /protein_id="NP_390259.1" /db_xref="EnsemblGenomes-Gn:BSU23780" /db_xref="EnsemblGenomes-Tr:CAB14310" /db_xref="GOA:P54554" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11746" /db_xref="UniProtKB/Swiss-Prot:P54554" /translation="MKHIAGKRIWITGASGGLGERIAYLCAAEGAHVLLSARREDRLI EIKRKITEEWSGQCEIFPLDVGRLEDIARVRDQIGSIDVLINNAGFGIFETVLDSTLD DMKAMFDVNVFGLIACTKAVLPQMLEQKKGHIINIASQAGKIATPKSSLYSATKHAVL GYSNALRMELSGTGIYVTTVNPGPIQTDFFSIADKGGDYAKNVGRWMLDPDDVAAQIT AAIFTKKREINLPRLMNAGTKLYQLFPALVEKLAGRALMKK*" /label="yqjQ CDS" gene complement(2140418..2141197) /gene="yqjQ" /locus_tag="BSU_23780" /old_locus_tag="BSU23780" /label="yqjQ gene" CDS complement(2141203..2142162) /gene="yqjP" /locus_tag="BSU_23790" /old_locus_tag="BSU23790" /EC_number="3.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent hydrolase" /protein_id="NP_390260.1" /db_xref="EnsemblGenomes-Gn:BSU23790" /db_xref="EnsemblGenomes-Tr:CAB14311" /db_xref="GOA:P54553" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG11745" /db_xref="UniProtKB/Swiss-Prot:P54553" /translation="MTTEDVIAIRVPTPFAVGDVIVYLVKGDALTLIDAGPNTKEAAR ALQEQLAAVNVKLSDIEQVVLTHHHADHAGLLDVFSDEIEVIGHTFNEPYISQNQAFM DWQKRFFQKLLPELGVPFDTGKAEKLIRSAYAFSCTRSLTKSIREGMGIDGLEGWSVL EMPGHAESHIVLFHEKSGRMLGGDLLLANSSSNPILEAPKAGDVRSKPLVDYQRSLRR LSQLDPTIVFPGHGEPITSVQALIEKRFDKQRNRTEDVRRMLDEKPMTAFQVCQQLFP AVYEKELFLTMSETAGHLDVLEAEEAITSYWEGNTVYFKTMKR*" /label="yqjP CDS" gene complement(2141203..2142162) /gene="yqjP" /locus_tag="BSU_23790" /old_locus_tag="BSU23790" /label="yqjP gene" promotor_-10 complement(2142184..2142203) /Source="Nicolas_upshift_promotors" /id="U1858" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.597402597402597" /psig=1 /xcortree=2254 /SigmaFactorBS="caatagctttttcaaaaaggtttgttctcattctgcaaTAAT GACAcaagaccgagaaaaAGCTAAAATATGAATAATGAatgaagacaaggagcgaaag g" /listShort="yqjP, yqjQ, S901, dsdA, S900, coaA, yqjT, S899" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2142203) /Source="Nicolas_upshifts" /id="U1858" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.597402597402597" /psig=1 /xcortree=2254 /SigmaFactorBS="caatagctttttcaaaaaggtttgttctcattctgcaaTAAT GACAcaagaccgagaaaaAGCTAAAATATGAATAATGAatgaagacaaggagcgaaag g" /listShort="yqjP, yqjQ, S901, dsdA, S900, coaA, yqjT, S899" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2142218..2142225) /Source="Nicolas_upshift_promotors" /id="U1858" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.597402597402597" /psig=1 /xcortree=2254 /SigmaFactorBS="caatagctttttcaaaaaggtttgttctcattctgcaaTAAT GACAcaagaccgagaaaaAGCTAAAATATGAATAATGAatgaagacaaggagcgaaag g" /listShort="yqjP, yqjQ, S901, dsdA, S900, coaA, yqjT, S899" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2142259..2142266 /Source="Nicolas_upshift_promotors" /id="U1859" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.784215784215784" /psig="0.992007992007992" /xcortree=573 /SigmaFactorBS="tcattattgcagaatgagaacaaacctttttgaaaaagcTAT TGACAttagcttgtccgccaTTGCATAATGAACAACAAACtaaaacgagaaccattgg a" /listShort="S902, proI" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2142280..2142566 /Source="Nicolas_S_feature" /locus_tag="new_2472864_2473150" /HighExp="Diami, C90, BC, Paraq, G180, GM 15, Oxctl, S7, MG-0.2, MG t5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S902" upshifts 2142280 /Source="Nicolas_upshifts" /id="U1859" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.784215784215784" /psig="0.992007992007992" /xcortree=573 /SigmaFactorBS="tcattattgcagaatgagaacaaacctttttgaaaaagcTAT TGACAttagcttgtccgccaTTGCATAATGAACAACAAACtaaaacgagaaccattgg a" /listShort="S902, proI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2142282..2142301 /Source="Nicolas_upshift_promotors" /id="U1859" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.784215784215784" /psig="0.992007992007992" /xcortree=573 /SigmaFactorBS="tcattattgcagaatgagaacaaacctttttgaaaaagcTAT TGACAttagcttgtccgccaTTGCATAATGAACAACAAACtaaaacgagaaccattgg a" /listShort="S902, proI" /GFF_Attribute="listLong" /label="promotor_-10" misc_RNA 2142296..2142541 /gene="pswI" /locus_tag="BSU_misc_RNA_91" /product="proline T-box riboswitch" /experiment="publication(s) with functional evidences, PMID:21233158" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21233158" /label="pswI RNA" gene 2142296..2142541 /gene="pswI" /locus_tag="BSU_misc_RNA_91" /label="pswI gene" CDS 2142567..2143403 /gene="proI" /locus_tag="BSU_23800" /old_locus_tag="BSU23800" /EC_number="1.5.1.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11418582, 21233158, 28752945, 28824574" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418582, 21233158, 28752945, 28824574; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyrroline-5-carboxylate reductase (NADP-dependent, weak activity)" /protein_id="NP_390261.1" /db_xref="EnsemblGenomes-Gn:BSU23800" /db_xref="EnsemblGenomes-Tr:CAB14312" /db_xref="GOA:P54552" /db_xref="InterPro:IPR000304" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR028939" /db_xref="InterPro:IPR029036" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11744" /db_xref="UniProtKB/Swiss-Prot:P54552" /translation="MKKIGFVGAGSMAEAMINGILQSGITKPEHIYITNRSNDERLIE LKETYSVRPCRDKNEFFTHTDIIILAFKPKDAAESIDSIRPYIKDQLVISVLAGLTIE TIQHYFGRKLAVIRVMPNTSAAIRKSATGFSVSTEASKNDIIAAKALLETIGDATLVE ERHLDAVTAIAGSGPAYVYRYIEAMEKAAQKVGLDKETAKALILQTMAGATDMLLQSG KQPEKLRKEITSPGGTTEAGLRALQDSRFEEAIIHCIEETAKRSAEIKEQFAGAALER HS*" /label="proI CDS" gene 2142567..2143403 /gene="proI" /locus_tag="BSU_23800" /old_locus_tag="BSU23800" /label="proI gene" downshifts 2143401 /Source="Nicolas_upshifts" /id="D1238" /incds=0 /nref=29 /ntot=190 /MaxReadThrough="0.55696" /MaxDrop="3.78131" /score="36.2472665" /energy="-12" /TU="NA" /idTUdmin="U1859" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2143444..2145087) /gene="yqjN" /locus_tag="BSU_23810" /old_locus_tag="BSU23810" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-deacylase" /protein_id="NP_390262.2" /db_xref="EnsemblGenomes-Gn:BSU23810" /db_xref="EnsemblGenomes-Tr:CAB14313" /db_xref="GOA:P54551" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR012166" /db_xref="SubtiList:BG11743" /db_xref="UniProtKB/Swiss-Prot:P54551" /translation="MNWQTKDELLALLTSLVQYESITGSKGEVALAEYLYFILKDKPY FQKHPDDVTLHPMDDGRSFLTALVKKKNVKKTVLLLSHFDVVDIEDYGEFKHMACKPA ELLSSFLEKKELLPERVRRDAESGDWLFGRGTMDMKAGLCIQLSMLERAMNGHFEGNL LLITVPDEEVNSRGMIEAVPALKEMEKKHDITLTACLNAEPMFEKFPGDQQQYFYTGS IGKVLAGFFCKGIETHVGEPFSGLNANLMVSEINRLLELNADYCEKVDGEVTPPPVNL MQKDLKEAYSVQTPHTAVTLFNVLSMKRSASELHQMLLKTAEQAAEEIMSNVRKKTQD FQQFEPFQPIERDVTVLTFDELVSRAKKRAGISETERALNYAFANRGELGDRDFSTKI VSELASLCKEDAPLIVLFYSPPLYPAVSSKDDQLIRNTADQIKHYAAERYGIALREVQ YFPGLSDLSYLQLEKQEVDAYTSNMPLFNRGYSLPSGKNQALYVPVLNVGPAGKDPHK WTERLYMPYSFEVLPDLLSFTISALLKQSESAGQLLREK*" /label="yqjN CDS" gene complement(2143444..2145087) /gene="yqjN" /locus_tag="BSU_23810" /old_locus_tag="BSU23810" /label="yqjN gene" downshifts complement(2143456) /Source="Nicolas_upshifts" /id="D1239" /incds=0 /nref=1 /ntot=62 /MaxReadThrough="2.2598" /MaxDrop="2.55609" /score="14.9380989" /energy="-12" /TU="NA" /idTUdmin="U1861" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2145105..2145111 /Source="Nicolas_upshift_promotors" /id="U1860" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.94105894105894" /psig="0.94105894105894" /xcortree=822 /SigmaFactorBS="cagcaattcgtccttcgtctgccaattcattgattccgcccc tcctaTGAATAAaaatgcttctataCTGAAAAATAAActgatttctcgtctattatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2145118 /Source="Nicolas_upshifts" /id="U1860" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.94105894105894" /psig="0.94105894105894" /xcortree=822 /SigmaFactorBS="cagcaattcgtccttcgtctgccaattcattgattccgcccc tcctaTGAATAAaaatgcttctataCTGAAAAATAAActgatttctcgtctattatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2145125..2145136 /Source="Nicolas_upshift_promotors" /id="U1860" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.94105894105894" /psig="0.94105894105894" /xcortree=822 /SigmaFactorBS="cagcaattcgtccttcgtctgccaattcattgattccgcccc tcctaTGAATAAaaatgcttctataCTGAAAAATAAActgatttctcgtctattatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature complement(2145143..2145162) /Source="Nicolas_upshift_promotors" /id="U1861" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.976023976023976" /psig="0.999000999001" /xcortree=397 /SigmaFactorBS="ctttcccgtcatataaactgctcaaatgaaccgcttttgtca aacaTTTCTGTATAATAGACGAGAaatcagtttatttttcagtatagaagcattttta t" /listShort="yqjN" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2145148) /Source="Nicolas_upshifts" /id="U1861" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.976023976023976" /psig="0.999000999001" /xcortree=397 /SigmaFactorBS="ctttcccgtcatataaactgctcaaatgaaccgcttttgtca aacaTTTCTGTATAATAGACGAGAaatcagtttatttttcagtatagaagcattttta t" /listShort="yqjN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2145194..2145201 /Source="Nicolas_upshift_promotors" /id="U1862" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.681318681318681" /psig="0.999000999001" /xcortree=1795 /SigmaFactorBS="cagaaatgtttgacaaaagcggttcatttgagcagttTATAT GACgggaaagaaatgaCTTGATATAATCAATCTCTAaaaaccttacgggaggcgaaag a" /listShort="yqjM, yqjL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2145215..2145234 /Source="Nicolas_upshift_promotors" /id="U1862" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.681318681318681" /psig="0.999000999001" /xcortree=1795 /SigmaFactorBS="cagaaatgtttgacaaaagcggttcatttgagcagttTATAT GACgggaaagaaatgaCTTGATATAATCAATCTCTAaaaaccttacgggaggcgaaag a" /listShort="yqjM, yqjL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2145217 /Source="Nicolas_upshifts" /id="U1862" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.681318681318681" /psig="0.999000999001" /xcortree=1795 /SigmaFactorBS="cagaaatgtttgacaaaagcggttcatttgagcagttTATAT GACgggaaagaaatgaCTTGATATAATCAATCTCTAaaaaccttacgggaggcgaaag a" /listShort="yqjM, yqjL" /GFF_Attribute="listLong" /label="upshifts" CDS 2145259..2146275 /gene="yqjM" /locus_tag="BSU_23820" /old_locus_tag="BSU23820" /EC_number="1.6.99.1" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12660247, 15249051, 15890652, 20011599, 20461254" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12660247, 15249051, 15890652, 20011599, 20461254; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADPH-dependent flavin oxidoreductase (acting oncinnamaldehyde-related compounds)" /protein_id="NP_390263.1" /db_xref="EnsemblGenomes-Gn:BSU23820" /db_xref="EnsemblGenomes-Tr:CAB14314" /db_xref="GOA:P54550" /db_xref="InterPro:IPR001155" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR023663" /db_xref="PDB:1Z41" /db_xref="PDB:1Z42" /db_xref="PDB:1Z44" /db_xref="PDB:1Z48" /db_xref="SubtiList:BG11742" /db_xref="UniProtKB/Swiss-Prot:P54550" /translation="MARKLFTPITIKDMTLKNRIVMSPMCMYSSHEKDGKLTPFHMAH YISRAIGQVGLIIVEASAVNPQGRITDQDLGIWSDEHIEGFAKLTEQVKEQGSKIGIQ LAHAGRKAELEGDIFAPSAIAFDEQSATPVEMSAEKVKETVQEFKQAAARAKEAGFDV IEIHAAHGYLIHEFLSPLSNHRTDEYGGSPENRYRFLREIIDEVKQVWDGPLFVRVSA SDYTDKGLDIADHIGFAKWMKEQGVDLIDCSSGALVHADINVFPGYQVSFAEKIREQA DMATGAVGMITDGSMAEEILQNGRADLIFIGRELLRDPFFARTAAKQLNTEIPAPVQY ERGW*" /label="yqjM CDS" gene 2145259..2146275 /gene="yqjM" /locus_tag="BSU_23820" /old_locus_tag="BSU23820" /label="yqjM gene" downshifts 2146262 /Source="Nicolas_upshifts" /id="D1240" /incds=0 /nref=42 /ntot=157 /MaxReadThrough="2.79686" /MaxDrop="5.04803" /score="39.119339" /energy="-12.8" /TU="U1862" /idTUdmin="U1862" /TUdmin="-770" /isTUend="FALSE" /label="downshifts" promotor_-35 2146324..2146333 /Source="Nicolas_upshift_promotors" /id="U1863" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1646 /SigmaFactorBS="atcctgtagaggatatctctttttttatttttagAGAAACGA TCggctaaggttctCCGTCTCCCTAGTAGAaccaattagaggagatgactccaatgaa a" /listShort="yqjL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2146346..2146361 /Source="Nicolas_upshift_promotors" /id="U1863" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1646 /SigmaFactorBS="atcctgtagaggatatctctttttttatttttagAGAAACGA TCggctaaggttctCCGTCTCCCTAGTAGAaccaattagaggagatgactccaatgaa a" /listShort="yqjL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2146350 /Source="Nicolas_upshifts" /id="U1863" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1646 /SigmaFactorBS="atcctgtagaggatatctctttttttatttttagAGAAACGA TCggctaaggttctCCGTCTCCCTAGTAGAaccaattagaggagatgactccaatgaa a" /listShort="yqjL" /GFF_Attribute="listLong" /label="upshifts" CDS 2146385..2147146 /gene="yqjL" /locus_tag="BSU_23830" /old_locus_tag="BSU23830" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15838020, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390264.1" /db_xref="EnsemblGenomes-Gn:BSU23830" /db_xref="EnsemblGenomes-Tr:CAB14315" /db_xref="InterPro:IPR022742" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG11741" /db_xref="UniProtKB/Swiss-Prot:P54549" /translation="MKSAWMEKTYTIDGCAFHTQHRKGSSGVTIVFEAGYGTSSETWK PLMADIDDEFGIFTYDRAGIGKSGQSRAKRTADQQVKELESLLKAADVKPPYLAVSHS YGAVITGLWACKNKHDIIGMVLLDPALGDCASFTFIPEEMHKSHTRKMMLEGTHAEFS KSLQELKKRQVHLGNMPLLVLSSGERTEKFAAEQEWQNLHSSILSLSNQSGWIQAKNS SHNIHHDEPHIVHLAIYDVWCAACQQAAPLYQAVN*" /label="yqjL CDS" gene 2146385..2147146 /gene="yqjL" /locus_tag="BSU_23830" /old_locus_tag="BSU23830" /label="yqjL gene" downshifts 2147054 /Source="Nicolas_upshifts" /id="D1241" /incds=1 /nref=21 /ntot=204 /MaxReadThrough="3.34804" /MaxDrop="3.21955" /score="0.451826768" /energy="-11.2" /TU="U1863" /idTUdmin="U1862" /TUdmin=22 /isTUend="TRUE" /label="downshifts" downshifts 2147142 /Source="Nicolas_upshifts" /id="D1242" /incds=0 /nref=4 /ntot=33 /MaxReadThrough="1.34151" /MaxDrop="3.85711" /score="0.451826768" /energy="-11.2" /TU="NA" /idTUdmin="U1863" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2147174..2147374) /Source="Nicolas_S_feature" /locus_tag="new_2477758_2477958_c" /HighExp="B60, S5, Etha, S4, B36, BMM, Heat, S3, S2, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.21631400000000001" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S903" CDS complement(2147190..2147315) /gene="rpmGCc" /locus_tag="BSU_23836" /old_locus_tag="BSU23836" /function="10.2: Ribosomal proteins: synthesis and modification" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 27561249; Product type s: structure" /pseudo /codon_start=1 /transl_table=11 /product="ribosomal protein L33* pseudogene" /translation="CTETGDRNYITTKNKRTNPDRLELKKYSPRLKKYTLHRETK*" /label="rpmGCc CDS" gene complement(2147190..2147315) /gene="rpmGCc" /locus_tag="BSU_23836" /old_locus_tag="BSU23836" /pseudo /label="rpmGCc gene" downshifts complement(2147217) /Source="Nicolas_upshifts" /id="D1243" /incds=0 /nref=187 /ntot=264 /MaxReadThrough="3.91531" /MaxDrop="7.65732" /score="5.23287853" /energy="-8.8" /TU="U1864" /idTUdmin="U1865" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(2147308..2147340) /gene="rpmGCn" /locus_tag="BSU_23837" /old_locus_tag="BSU23837" /function="10.2: Ribosomal proteins: synthesis and modification" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 19648245, 27561249; Product type s: structure" /pseudo /codon_start=1 /transl_table=11 /product="ribosomal protein L33C pseudogene" /db_xref="PSEUDO:CCQ48601.1" /translation="MRVNVTLALH*" /label="rpmGCn CDS" gene complement(2147308..2147340) /gene="rpmGCn" /locus_tag="BSU_23837" /old_locus_tag="BSU23837" /pseudo /label="rpmGCn gene" promotor_-10 complement(2147368..2147387) /Source="Nicolas_upshift_promotors" /id="U1864" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.597402597402597" /psig=1 /xcortree=665 /SigmaFactorBS="cccgcgaggctgaaggcggagctcttaTTTGACAAtttgtga tgacgTTGTATAATAAAACGTAATCattacgttttataaggagatgttaattatgaga g" /listShort="S903" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2147374) /Source="Nicolas_upshifts" /id="U1864" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.597402597402597" /psig=1 /xcortree=665 /SigmaFactorBS="cccgcgaggctgaaggcggagctcttaTTTGACAAtttgtga tgacgTTGTATAATAAAACGTAATCattacgttttataaggagatgttaattatgaga g" /listShort="S903" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2147400..2147407) /Source="Nicolas_upshift_promotors" /id="U1864" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.597402597402597" /psig=1 /xcortree=665 /SigmaFactorBS="cccgcgaggctgaaggcggagctcttaTTTGACAAtttgtga tgacgTTGTATAATAAAACGTAATCattacgttttataaggagatgttaattatgaga g" /listShort="S903" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2147422..2148345) /gene="rnz" /locus_tag="BSU_23840" /old_locus_tag="BSU23840" /EC_number="3.1.26.11" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12682299, 12941704, 16336119, 17005971" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 12941704, 16336119, 17005971; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease Z" /protein_id="NP_390265.1" /db_xref="EnsemblGenomes-Gn:BSU23840" /db_xref="EnsemblGenomes-Tr:CAB14316" /db_xref="GOA:P54548" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR013471" /db_xref="InterPro:IPR036866" /db_xref="PDB:1Y44" /db_xref="PDB:2FK6" /db_xref="PDB:4GCW" /db_xref="SubtiList:BG11740" /db_xref="UniProtKB/Swiss-Prot:P54548" /translation="MELLFLGTGAGIPAKARNVTSVALKLLEERRSVWLFDCGEATQH QILHTTIKPRKIEKIFITHMHGDHVYGLPGLLGSRSFQGGEDELTVYGPKGIKAFIET SLAVTKTHLTYPLAIQEIEEGIVFEDDQFIVTAVSVIHGVEAFGYRVQEKDVPGSLKA DVLKEMNIPPGPVYQKIKKGETVTLEDGRIINGNDFLEPPKKGRSVVFSGDTRVSDKL KELARDCDVLVHEATFAKEDRKLAYDYYHSTTEQAAVTAKEARAKQLILTHISARYQG DASLELQKEAVDVFPNSVAAYDFLEVNVPRG*" /label="rnz CDS" gene complement(2147422..2148345) /gene="rnz" /locus_tag="BSU_23840" /old_locus_tag="BSU23840" /label="rnz gene" promotor_-10 complement(2148371..2148390) /Source="Nicolas_upshift_promotors" /id="U1865" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2380 /SigmaFactorBS="tctagcacgaaaggattgttcttttcagaggcaagATTCACa ttttccgcttgaTCCTGTATTCTTGTAGGTATctggttctagtaggaggaaggaaacg t" /listShort="rnz, S903" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2148384) /Source="Nicolas_upshifts" /id="U1865" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2380 /SigmaFactorBS="tctagcacgaaaggattgttcttttcagaggcaagATTCACa ttttccgcttgaTCCTGTATTCTTGTAGGTATctggttctagtaggaggaaggaaacg t" /listShort="rnz, S903" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2148404..2148409) /Source="Nicolas_upshift_promotors" /id="U1865" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2380 /SigmaFactorBS="tctagcacgaaaggattgttcttttcagaggcaagATTCACa ttttccgcttgaTCCTGTATTCTTGTAGGTATctggttctagtaggaggaaggaaacg t" /listShort="rnz, S903" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2148483..2148490 /Source="Nicolas_upshift_promotors" /id="U1866" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.676323676323676" /psig=1 /xcortree=2347 /SigmaFactorBS="acattttttcagcattctgcttaaaaaagggcttaaaTGTTT GCTttcgttgaattttAGATTTAAAATGAAGGAAATatacggggtgtactaaaataaa g" /listShort="S904, zwf" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2148504..2148523 /Source="Nicolas_upshift_promotors" /id="U1866" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.676323676323676" /psig=1 /xcortree=2347 /SigmaFactorBS="acattttttcagcattctgcttaaaaaagggcttaaaTGTTT GCTttcgttgaattttAGATTTAAAATGAAGGAAATatacggggtgtactaaaataaa g" /listShort="S904, zwf" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2148506..2148571 /Source="Nicolas_S_feature" /locus_tag="new_2479090_2479155" /HighExp="dia5, C90, MG 5, Lbexp, MG t5, MG 45, M9-exp, GM 90, GM 120, GM-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S904" upshifts 2148506 /Source="Nicolas_upshifts" /id="U1866" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.676323676323676" /psig=1 /xcortree=2347 /SigmaFactorBS="acattttttcagcattctgcttaaaaaagggcttaaaTGTTT GCTttcgttgaattttAGATTTAAAATGAAGGAAATatacggggtgtactaaaataaa g" /listShort="S904, zwf" /GFF_Attribute="listLong" /label="upshifts" CDS 2148572..2150041 /gene="zwf" /locus_tag="BSU_23850" /old_locus_tag="BSU23850" /EC_number="1.1.1.49" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1704005, 19779711, 26129872" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1704005, 19779711, 26129872; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucose-6-phosphate 1-dehydrogenase (NADP-dependent)" /protein_id="NP_390266.2" /db_xref="EnsemblGenomes-Gn:BSU23850" /db_xref="EnsemblGenomes-Tr:CAB14317" /db_xref="GOA:P54547" /db_xref="InterPro:IPR001282" /db_xref="InterPro:IPR019796" /db_xref="InterPro:IPR022674" /db_xref="InterPro:IPR022675" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11739" /db_xref="UniProtKB/Swiss-Prot:P54547" /translation="MKTNQQPKAVIVIFGATGDLAKRKLYPSIHRLYQNGQIGEEFAV VGVGRRPWSNEDLRQTVKTSISSSADKHIDDFTSHFYYHPFDVTNPGSYQELNVLLNQ LEDTYQIPNNRMFYLAMAPEFFGTIAKTLKSEGVTATTGWSRLVIEKPFGHDLPSAQA LNKEIREAFTEDQIYRIDHYLGKQMVQNIEVIRFANAIFEPLWTNRYISNIQITSSES LGVEDRARYYEKSGALRDMVQNHIMQMVALLAMEPPIKLNTEEIRSEKVKVLRALRPI AKDEVDEYFVRGQYHAGEIDGVPVPAYTDEDNVAPDSNTETFVAGKLLIDNFRWAGVP FYIRTGKRMKEKSTKIVVQFKDIPMNLYYGNENNMNPNLLVIHIQPDEGITLYLNAKK LGGAAHAQPIKLDYCSNCNDELNTPEAYEKLIHDCLLGDATNFAHWDEVALSWSFVDS ISETWAANKTLSPNYESGSMGPKESDDLLVKDGLHWWNI*" /label="zwf CDS" gene 2148572..2150041 /gene="zwf" /locus_tag="BSU_23850" /old_locus_tag="BSU23850" /label="zwf gene" downshifts 2150024 /Source="Nicolas_upshifts" /id="D1244" /incds=0 /nref=206 /ntot=286 /MaxReadThrough="3.46838" /MaxDrop="7.76173" /score="1.1363172" /energy="-15.2" /TU="U1866" /idTUdmin="U1866" /TUdmin="-90" /isTUend="FALSE" /label="downshifts" terminator 2150049..2150088 /created_by="User" /comment="zwf-T-gndA_terminator_improvement" /modified_by="User" /label="Delta6_zwf-T-gndA_Terminator" Polymorphism join(2150061,2150064) /Source="geneious" /ID="SNP_BsDelta6_2480646_2480647" /Polymorphism_Type="Substitution" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=2 /Amino_Acid_Change /CDS_Position /Change="TA -> AT" /Codon_Change /Coverage=115 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides="TA" /Variant_Nucleotides="AT" /Variant_P_Value=0 /Variant_Raw_Frequency=113 /comment="zwf-T-gndA_terminator_improvement" /modified_by="User" / /label="Polymorphism_Delta6" Polymorphism join(2150069,2150070) /Source="geneious" /ID="SNP_BsDelta6_2480654_2480654" /Polymorphism_Type="Deletion" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change /CDS_Position /Change="-T" /Codon_Change /Coverage=115 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides /Variant_P_Value="2.1e-279" /Variant_Raw_Frequency=113 /comment="zwf-T-gndA_terminator_improvement" /modified_by="User" / /label="Polymorphism_Delta6" Polymorphism join(2150081,2150082) /Source="geneious" /ID="SNP_BsDelta6_2480667_2480667" /Polymorphism_Type="Deletion" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change /CDS_Position /Change="-T" /Codon_Change /Coverage=116 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides /Variant_P_Value="2.9e-244" /Variant_Raw_Frequency=110 /comment="zwf-T-gndA_terminator_improvement" /modified_by="User" / /label="Polymorphism_Delta6" downshifts 2150090 /Source="Nicolas_upshifts" /id="D1245" /incds=0 /nref=1 /ntot=104 /MaxReadThrough="2.5392" /MaxDrop="4.74183" /score="1.1363172" /energy="-15.2" /TU="U1866" /idTUdmin="U1866" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(2150164..2151573) /gene="gndA" /locus_tag="BSU_23860" /old_locus_tag="BSU23860" /EC_number="1.1.1.44" /function="16.2: Construct biomass (Anabolism)" /function="16.7: Manage energy" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15231785, 15755726" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15231785, 15755726; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADP+-dependent 6-P-gluconate dehydrogenase" /protein_id="NP_390267.2" /db_xref="EnsemblGenomes-Gn:BSU23860" /db_xref="EnsemblGenomes-Tr:CAB14318" /db_xref="GOA:P80859" /db_xref="InterPro:IPR006113" /db_xref="InterPro:IPR006114" /db_xref="InterPro:IPR006115" /db_xref="InterPro:IPR006183" /db_xref="InterPro:IPR006184" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11738" /db_xref="UniProtKB/Swiss-Prot:P80859" /translation="MSKQQIGVIGLAVMGKNLALNIESRGFSVSVYNRSSSKTEEFLQ EAKGKNVVGTYSIEEFVQSLETPRKILLMVKAGTATDATIQSLLPHLEKDDILIDGGN TYYKDTQRRNKELAESGIHFIGTGVSGGEEGALKGPSIMPGGQKEAHELVKPILEAIS AKVDGEPCTTYIGPDGAGHYVKMVHNGIEYGDMQLISESYFILKQVLGLSADELHEVF AEWNKGELDSYLIEITADIFTKKDEETGKPLVDVILDKAGQKGTGKWTSQSALDLGVP LPIITESVFARFISAMKEERVKASGLLSGPEVKPVTENKEELIEAVRKALFMSKICSY AQGFAQMKAASEEYNWDLKYGEIAMIFRGGCIIRAAFLQKIKEAYDREPELDNLLLDS YFKNIVESYQGALRQVISLAVAQGVPVPSFSSALAYYDSYRTAVLPANLIQAQRDYFG AHTYERTDKEGIFHTEWMK*" /label="gndA CDS" gene complement(2150164..2151573) /gene="gndA" /locus_tag="BSU_23860" /old_locus_tag="BSU23860" /label="gndA gene" downshifts complement(2150181) /Source="Nicolas_upshifts" /id="D1246" /incds=0 /nref=220 /ntot=361 /MaxReadThrough="1.88983" /MaxDrop="8.82894" /score="24.3727084" /energy="-18" /TU="NA" /idTUdmin="U1867" /TUdmin="-15" /isTUend="TRUE" /label="downshifts" downshifts complement(2150254) /Source="Nicolas_upshifts" /id="D1247" /incds=1 /nref=1 /ntot=36 /MaxReadThrough="8.40595" /MaxDrop="2.3555" /score="24.3727084" /energy="-18" /TU="U1867" /idTUdmin="U1867" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" misc_feature complement(2151637..2151655) /Source="Nicolas_upshift_promotors" /id="U1867" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.377622377622378" /psig="0.987012987012987" /xcortree=2358 /SigmaFactorBS="atgaaaagaaaagctgaatcgcttgaaaaaaagggtgaatgt atGGTAATTTCTTTATTATAAatatcattttattttaatttaaattttaaaatgatta a" /listShort="gndA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2151639) /Source="Nicolas_upshifts" /id="U1867" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.377622377622378" /psig="0.987012987012987" /xcortree=2358 /SigmaFactorBS="atgaaaagaaaagctgaatcgcttgaaaaaaagggtgaatgt atGGTAATTTCTTTATTATAAatatcattttattttaatttaaattttaaaatgatta a" /listShort="gndA" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2151683..2152927) /gene="polYA" /locus_tag="BSU_23870" /old_locus_tag="BSU23870" /EC_number="2.7.7.7" /function="16.6: Maintain" /function="16.5: Explore" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12137951, 12644484, 15469515, 16045613, 25713353" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12137951, 12644484, 15469515, 16045613, 25713353; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA-damage lesion bypass DNA polymerase" /protein_id="NP_390268.2" /db_xref="EnsemblGenomes-Gn:BSU23870" /db_xref="EnsemblGenomes-Tr:CAB14319" /db_xref="GOA:P54545" /db_xref="InterPro:IPR001126" /db_xref="InterPro:IPR017061" /db_xref="InterPro:IPR017961" /db_xref="InterPro:IPR022880" /db_xref="InterPro:IPR024728" /db_xref="InterPro:IPR036775" /db_xref="SubtiList:BG11737" /db_xref="UniProtKB/Swiss-Prot:P54545" /translation="MPGKSRIIFHIDMNSFYASVEMAYDPALRGKPVAVAGNVKERKG IVVTCSYEARARGVKTTMPVWQAKRHCPELIVLPPNFDRYRNSSRAMFTILREYTDLV EPVSIDEGYMDMTDTPYSSRALETAKEIQSRLQKELLLPSSIGIAPNKFLAKMASDMK KPLGITILRKRQVPDILWPLPVGEMHGVGKKTAEKLKGLGIHTIGELAAADEHSLKRL LGINGPRLKNKANGIHHAPVDPERIYEFKSVGNSSTLSHDSSDEEELLGVFRKLAASV SDRLQRKEVMASKLFIMIRYADWRTITRSTTLRNPIDQKNDILKEAEHLFFKHWNKNP VRLLGITGTDLVEKEQAYKQLDLFSFNEDAKDEPIQQMMEKLNKKYGTKLIRKGATLK KEESKTKGTSFNKDFFQDEKKS*" /label="polYA CDS" gene complement(2151683..2152927) /gene="polYA" /locus_tag="BSU_23870" /old_locus_tag="BSU23870" /label="polYA gene" S_feature complement(2152928..2153202) /Source="Nicolas_S_feature" /locus_tag="new_2483514_2483788_c" /HighExp="M40t90, Sw, M40t45, H2O2, C30, Cold, Etha, C90, Diami, BC" /AntisenseName="yqzJ" /AntisenseCor="0.48883700687558601" /AntisenseRegPval="-16.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S905" promotor_-35 2152948..2152955 /Source="Nicolas_upshift_promotors" /id="U1868" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.635364635364635" /psig="0.994005994005994" /xcortree=2144 /SigmaFactorBS="ttcggctctttcccggcataaacaaatctccttttcggtCAT TAGACaacagcttgtacaTATAGTAAAATGAAGCTATTgaatggatgtgatgacaatg t" /listShort="yqzJ, oxaAB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2152969..2152988 /Source="Nicolas_upshift_promotors" /id="U1868" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.635364635364635" /psig="0.994005994005994" /xcortree=2144 /SigmaFactorBS="ttcggctctttcccggcataaacaaatctccttttcggtCAT TAGACaacagcttgtacaTATAGTAAAATGAAGCTATTgaatggatgtgatgacaatg t" /listShort="yqzJ, oxaAB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2152969 /Source="Nicolas_upshifts" /id="U1868" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.635364635364635" /psig="0.994005994005994" /xcortree=2144 /SigmaFactorBS="ttcggctctttcccggcataaacaaatctccttttcggtCAT TAGACaacagcttgtacaTATAGTAAAATGAAGCTATTgaatggatgtgatgacaatg t" /listShort="yqzJ, oxaAB" /GFF_Attribute="listLong" /label="upshifts" CDS 2153000..2153287 /gene="mifM" /locus_tag="BSU_23880" /old_locus_tag="BSU23880" /experiment="publication(s) with functional evidences, PMID:19779460, 21383133, 22720735, 25313395, 25903689" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19779460, 21383133, 22720735, 25313395, 25903689; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of OxaAB translation" /protein_id="YP_054586.1" /db_xref="EnsemblGenomes-Gn:BSU23880" /db_xref="EnsemblGenomes-Tr:CAE01460" /db_xref="GOA:Q7WY64" /db_xref="PDB:3J9W" /db_xref="SubtiList:BG14191" /db_xref="UniProtKB/Swiss-Prot:Q7WY64" /translation="MTMFVESINDVLFLVDFFTIILPALTAIGIAFLLRECRAGEQWK SKRTDEHQTVFHINRTDFLIIIYHRITTWIRKVFRMNSPVNDEEDAGSLLL*" /label="mifM CDS" gene 2153000..2153287 /gene="mifM" /locus_tag="BSU_23880" /old_locus_tag="BSU23880" /label="mifM gene" promotor_-10 complement(2153184..2153203) /Source="Nicolas_upshift_promotors" /id="U1869" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.554445554445554" /psig="0.993006993006993" /xcortree=2094 /SigmaFactorBS="cttcctcatcgttcacaggcgaattcatgcggaagactttac GTATccaagttgtaatgcgATGATATATAATAATAAGAAagtctgttcggttaatgtg a" /listShort="S905, polYA" /listLong="gndA" /label="promotor_-10" upshifts complement(2153204) /Source="Nicolas_upshifts" /id="U1869" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.554445554445554" /psig="0.993006993006993" /xcortree=2094 /SigmaFactorBS="cttcctcatcgttcacaggcgaattcatgcggaagactttac GTATccaagttgtaatgcgATGATATATAATAATAAGAAagtctgttcggttaatgtg a" /listShort="S905, polYA" /listLong="gndA" /label="upshifts" promotor_-35 complement(2153219..2153222) /Source="Nicolas_upshift_promotors" /id="U1869" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.554445554445554" /psig="0.993006993006993" /xcortree=2094 /SigmaFactorBS="cttcctcatcgttcacaggcgaattcatgcggaagactttac GTATccaagttgtaatgcgATGATATATAATAATAAGAAagtctgttcggttaatgtg a" /listShort="S905, polYA" /listLong="gndA" /label="promotor_-35" CDS 2153318..2154145 /gene="oxaAB" /locus_tag="BSU_23890" /old_locus_tag="BSU23890" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11889108, 15654078, 15671040, 15849754, 16293689, 16850406, 21204254, 24443530, 24739968, 25903689" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11889108, 15654078, 15671040, 15849754, 16293689, 16850406, 21204254, 24443530, 24739968, 25903689; Product type f: factor" /codon_start=1 /transl_table=11 /product="Sec-independent factor for membrane protein insertion (YidC/SpoIIIJ family)" /protein_id="NP_390269.1" /db_xref="EnsemblGenomes-Gn:BSU23890" /db_xref="EnsemblGenomes-Tr:CAB14320" /db_xref="GOA:P54544" /db_xref="InterPro:IPR001708" /db_xref="InterPro:IPR023060" /db_xref="InterPro:IPR028055" /db_xref="SubtiList:BG11736" /db_xref="UniProtKB/Swiss-Prot:P54544" /translation="MLKTYQKLLAMGIFLIVLCSGNAAFAATNQVGGLSNVGFFHDYL IEPFSALLKGVAGLFHGEYGLSIILVTIIVRIVVLPLFVNQFKKQRIFQEKMAVIKPQ VDSIQVKLKKTKDPEKQKELQMEMMKLYQEHNINPLAMGCLPMLIQSPIMIGLYYAIR STPEIASHSFLWFSLGQSDILMSLSAGIMYFVQAYIAQKLSAKYSAVPQNPAAQQSAK LMVFIFPVMMTIFSLNVPAALPLYWFTSGLFLTVQNIVLQMTHHKSKKTAALTESVK* " /label="oxaAB CDS" gene 2153318..2154145 /gene="oxaAB" /locus_tag="BSU_23890" /old_locus_tag="BSU23890" /label="oxaAB gene" downshifts 2153962 /Source="Nicolas_upshifts" /id="D1248" /incds=1 /nref=4 /ntot=125 /MaxReadThrough="5.05074" /MaxDrop="3.49092" /score="-5.67811369" /energy="-7.6" /TU="U1868" /idTUdmin="U1868" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" downshifts 2154138 /Source="Nicolas_upshifts" /id="D1249" /incds=0 /nref=71 /ntot=229 /MaxReadThrough="1.09826" /MaxDrop="6.56698" /score="-5.67811369" /energy="-7.6" /TU="NA" /idTUdmin="U1868" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2154150..2155070) /Source="Nicolas_S_feature" /locus_tag="new_2484736_2485656_c" /HighExp="LoTm, B36, M0t90, M40t90, Lbstat, M9-stat, T1.30H, B60, LBGtran, BT" /AntisenseName="yqjF" /AntisenseCor="0.18628881890353799" /AntisenseRegPval="-2.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S906" downshifts complement(2154193) /Source="Nicolas_upshifts" /id="D1250" /incds=0 /nref=170 /ntot=248 /MaxReadThrough="0.24428" /MaxDrop="6.31082" /score="18.1943524" /energy="-12.4" /TU="NA" /idTUdmin="U1871" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 2154263..2154269 /Source="Nicolas_upshift_promotors" /id="U1870" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=161 /SigmaFactorBS="cagaaatggccatcctaaaaaatagccgtatCGTTTAAaaag aaggaaatcGGGAATACCTTTACTCACCtccaaccgaaaggagcctatacgttgacgg a" /listShort="yqjF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2154283..2154301 /Source="Nicolas_upshift_promotors" /id="U1870" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=161 /SigmaFactorBS="cagaaatggccatcctaaaaaatagccgtatCGTTTAAaaag aaggaaatcGGGAATACCTTTACTCACCtccaaccgaaaggagcctatacgttgacgg a" /listShort="yqjF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2154292 /Source="Nicolas_upshifts" /id="U1870" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=161 /SigmaFactorBS="cagaaatggccatcctaaaaaatagccgtatCGTTTAAaaag aaggaaatcGGGAATACCTTTACTCACCtccaaccgaaaggagcctatacgttgacgg a" /listShort="yqjF" /GFF_Attribute="listLong" /label="upshifts" CDS 2154325..2155053 /gene="yqjF" /locus_tag="BSU_23900" /old_locus_tag="BSU23900" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390270.3" /db_xref="EnsemblGenomes-Gn:BSU23900" /db_xref="EnsemblGenomes-Tr:CAB14321" /db_xref="InterPro:IPR018644" /db_xref="InterPro:IPR023375" /db_xref="SubtiList:BG11735" /db_xref="UniProtKB/Swiss-Prot:P54543" /translation="MTERFQQKNISVPDGIWIMRQTWNDVLFAHWPVDVSILRALVPS VLELDTYNGQAWISMLPFMLTNLRARYLPVIPGARAFPELNLRTYVTYKGKPGIYFFS LDADHRLAVLGARTFFHLPYFYADMKSEKNGDAIDYVSKRKNDKEAAFHAAYRPISAP FTAEKDSLDYWLTERYRLYTTYRNKLYYEDIHHHPWLLQNAEAEISVNTVTDAHGITL PESDPLLHYAKKQDVLFWPLRKWS*" /label="yqjF CDS" gene 2154325..2155053 /gene="yqjF" /locus_tag="BSU_23900" /old_locus_tag="BSU23900" /label="yqjF gene" CDS complement(2155094..2156209) /gene="yqjE" /locus_tag="BSU_23910" /old_locus_tag="BSU23910" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative peptidase or deacylase" /protein_id="NP_390271.2" /db_xref="EnsemblGenomes-Gn:BSU23910" /db_xref="EnsemblGenomes-Tr:CAB14322" /db_xref="GOA:P54542" /db_xref="InterPro:IPR001261" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR008007" /db_xref="InterPro:IPR010162" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG11734" /db_xref="UniProtKB/Swiss-Prot:P54542" /translation="MVNEKRLLEEFLELVQIDSETKHEAEICKVLKRKFSDLGVDVKE DDTMDITGHGAGNLICTLKGTKQTDTIYFTSHMDTVVPGNGVKPVVENGYVKTDGTTI LGADDKAGLAAMFEAIKVLKEENIEHGTIEFIITVGEESGLIGAKALDRSMITASYGY ALDSDGKVGNIIVAAPTQAKVRAAIFGKTAHAGVEPEKGISAITIASKAISKMPLGRI DEETTANIGRFEGGTQTNIVCDEVHILAEARSLVPEKMEAQVQKMKAAFEEAAADMGG RAEVEIEVMYPGFKYQDGDQVVEIAKKAAAKIGRPSELQTSGGGSDANVIAGHGIPTV NLAVGYEQIHTKNEKMPIEELVKTAEMVVAIIEEAAK*" /label="yqjE CDS" gene complement(2155094..2156209) /gene="yqjE" /locus_tag="BSU_23910" /old_locus_tag="BSU23910" /label="yqjE gene" downshifts complement(2155115) /Source="Nicolas_upshifts" /id="D1251" /incds=0 /nref=23 /ntot=203 /MaxReadThrough="3.90071" /MaxDrop="3.95711" /score="11.6635037" /energy="-10.6" /TU="U1871" /idTUdmin="U1871" /TUdmin="-923" /isTUend="FALSE" /label="downshifts" CDS complement(2156227..2157750) /gene="yqjD" /locus_tag="BSU_23920" /old_locus_tag="BSU23920" /EC_number="6.4.1.3" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative propionyl-CoA carboxylase beta chain" /protein_id="NP_390272.2" /db_xref="EnsemblGenomes-Gn:BSU23920" /db_xref="EnsemblGenomes-Tr:CAB14323" /db_xref="GOA:P54541" /db_xref="InterPro:IPR000438" /db_xref="InterPro:IPR011762" /db_xref="InterPro:IPR011763" /db_xref="InterPro:IPR029045" /db_xref="InterPro:IPR034733" /db_xref="SubtiList:BG11733" /db_xref="UniProtKB/Swiss-Prot:P54541" /translation="MNEHMDHFYTKRKQAEEGGGREKLAQQRQKGKLTARERIIFLLD QDSFIELHPFMESQVLTREQRMLGDGVVTGYGTIDGRSVYVFAQDFTVYGGALGETHA RKICALMDLAAKNKAPIIGLNDSGGARIQEGVLSLDGYGHIFYRNVLYSGVIPQISVI LGPCAGGAVYSPALTDFIFMAEQTGRMFITGPKVIEKVTGEQVDAESLGGAGIHNAVS GNAHFSGHTEKEVLTGVRKLLSYLPLNGRTTEPKPEKEASRPLLNRLVPADTTKPYDV RKVIRELADPQSFFEIQPFFAKNIVIGFARLGEKAIGIVASQPKHLAGSLTIDAADKA ARFIRFCDAFDIPLLTVEDVPGFLPGIQQEHNGIIRHGAKLLFAYAEATVPKVTLIIR KAYGGAYVAMNSKAIGADLVFAWPNAEIAVMGPEGAASILYEKEIKASADPQKTKREK TAEYKKQNAGPYKAAACGMVDDIILPEESRGRLIQAFHMLTHKTEERPKKKHGNIPL* " /label="yqjD CDS" gene complement(2156227..2157750) /gene="yqjD" /locus_tag="BSU_23920" /old_locus_tag="BSU23920" /label="yqjD gene" promotor_-10 complement(2157333..2157352) /Source="Nicolas_upshift_promotors" /id="U1871" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.504495504495505" /psig="0.999000999001" /xcortree=1916 /SigmaFactorBS="agcaaaaaataaggcgccgattatcgggctgaatgactcagg tgGTGCGagaattcaagagggTGTGTTATCATTAGATGGATacggtcacatattttac c" /listShort="yqjE, S906" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2157355) /Source="Nicolas_upshifts" /id="U1871" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.504495504495505" /psig="0.999000999001" /xcortree=1916 /SigmaFactorBS="agcaaaaaataaggcgccgattatcgggctgaatgactcagg tgGTGCGagaattcaagagggTGTGTTATCATTAGATGGATacggtcacatattttac c" /listShort="yqjE, S906" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2157367..2157371) /Source="Nicolas_upshift_promotors" /id="U1871" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.504495504495505" /psig="0.999000999001" /xcortree=1916 /SigmaFactorBS="agcaaaaaataaggcgccgattatcgggctgaatgactcagg tgGTGCGagaattcaagagggTGTGTTATCATTAGATGGATacggtcacatattttac c" /listShort="yqjE, S906" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2157743..2158165) /gene="yqjC" /locus_tag="BSU_23930" /old_locus_tag="BSU23930" /EC_number="5.1.99.1" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative methylmalonyl-CoA epimerase" /protein_id="NP_390273.2" /db_xref="EnsemblGenomes-Gn:BSU23930" /db_xref="EnsemblGenomes-Tr:CAB14324" /db_xref="GOA:P54540" /db_xref="InterPro:IPR017515" /db_xref="InterPro:IPR018146" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG11732" /db_xref="UniProtKB/Swiss-Prot:P54540" /translation="MNRLDHIGIAVFSIKDARSFYENVLGLAFLHQETVEEQKVNVAF FQAGSVKLELIEPLTADSPVHLFLEKKGQGLHHIAFLCNCLSEQLQALSDQHVQLIDR FPRQGANGKKIAFISPRETNGVLVELCEPKGDQHNEHE*" /label="yqjC CDS" gene complement(2157743..2158165) /gene="yqjC" /locus_tag="BSU_23930" /old_locus_tag="BSU23930" /label="yqjC gene" promotor_-35 2158194..2158201 /Source="Nicolas_upshift_promotors" /id="U1872" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=1904 /SigmaFactorBS="catccctgctttcgctaatagatatCGCTTGTCcgcccattc aaaaCACGCTAAAATATAGACAGAttgtttaaggagtgaaaatcatgtctcaaaaact g" /listShort="S907, S908" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2158215..2158234 /Source="Nicolas_upshift_promotors" /id="U1872" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=1904 /SigmaFactorBS="catccctgctttcgctaatagatatCGCTTGTCcgcccattc aaaaCACGCTAAAATATAGACAGAttgtttaaggagtgaaaatcatgtctcaaaaact g" /listShort="S907, S908" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2158229..2158382 /Source="Nicolas_S_feature" /locus_tag="new_2488815_2488968" /HighExp="LPhT, Etha, dia15, Salt, M9-stat, LBGstat, Heat, BC, T-0.40H, HiOs" /AntisenseName="yqjB" /AntisenseCor="-0.57221813594264503" /AntisenseRegPval="-24.1" /CDS_PredictionProba="0.99822200000000005" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S907" upshifts 2158229 /Source="Nicolas_upshifts" /id="U1872" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=1904 /SigmaFactorBS="catccctgctttcgctaatagatatCGCTTGTCcgcccattc aaaaCACGCTAAAATATAGACAGAttgtttaaggagtgaaaatcatgtctcaaaaact g" /listShort="S907, S908" /GFF_Attribute="listLong" /label="upshifts" downshifts 2158339 /Source="Nicolas_upshifts" /id="D1252" /incds=0 /nref=1 /ntot=140 /MaxReadThrough="3.88708" /MaxDrop="3.25163" /score="3.10927996" /energy="-7" /TU="U1872" /idTUdmin="U1872" /TUdmin="-638" /isTUend="FALSE" /label="downshifts" CDS complement(2158367..2158897) /gene="yqjB" /locus_tag="BSU_23940" /old_locus_tag="BSU23940" /EC_number="2.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative L,D-transpeptidase" /protein_id="NP_390274.1" /db_xref="EnsemblGenomes-Gn:BSU23940" /db_xref="EnsemblGenomes-Tr:CAB14325" /db_xref="GOA:P54539" /db_xref="InterPro:IPR005490" /db_xref="SubtiList:BG11731" /db_xref="UniProtKB/Swiss-Prot:P54539" /translation="MRFFLCSIFMMISPIWPLGENPLPGDPYVIVNKRTNELAVILDN KVEGVYSVATGKTDDLTPEGEFSVTVKAENPYYRKKNIEGGSPDNPLGARWIGFDAKG TDGRIYGIHGTNREESVGKFVSNGCIRMHNDEVVHLFQTIPVGTRVLITDDNRSFEEI AIEHKALIKKQDIPIE*" /label="yqjB CDS" gene complement(2158367..2158897) /gene="yqjB" /locus_tag="BSU_23940" /old_locus_tag="BSU23940" /label="yqjB gene" S_feature 2158384..2159019 /Source="Nicolas_S_feature" /locus_tag="new_2488970_2489605" /HighExp="LPhT, H2O2, BC, Salt, dia15, M9-stat, Heat, LBGstat, T5.0H, Etha" /AntisenseName="yqjB" /AntisenseCor="-0.31126010332536502" /AntisenseRegPval="-6.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S908" promotor_-10 complement(2158914..2158925) /Source="Nicolas_upshift_promotors" /id="U1873" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=825 /SigmaFactorBS="aaaggaataaaagcgcaaaaatcactcggatgattCGCATGA gctcttccttcattGGTCAACCTAATgaaaaaggaggagcttatgcgttttttcttat g" /listShort="yqjB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2158921) /Source="Nicolas_upshifts" /id="U1873" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=825 /SigmaFactorBS="aaaggaataaaagcgcaaaaatcactcggatgattCGCATGA gctcttccttcattGGTCAACCTAATgaaaaaggaggagcttatgcgttttttcttat g" /listShort="yqjB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2158940..2158946) /Source="Nicolas_upshift_promotors" /id="U1873" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=825 /SigmaFactorBS="aaaggaataaaagcgcaaaaatcactcggatgattCGCATGA gctcttccttcattGGTCAACCTAATgaaaaaggaggagcttatgcgttttttcttat g" /listShort="yqjB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2158949..2159917) /gene="yqjA" /locus_tag="BSU_23950" /old_locus_tag="BSU23950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390275.2" /db_xref="EnsemblGenomes-Gn:BSU23950" /db_xref="EnsemblGenomes-Tr:CAB14326" /db_xref="GOA:P54538" /db_xref="InterPro:IPR010343" /db_xref="InterPro:IPR021062" /db_xref="SubtiList:BG11730" /db_xref="UniProtKB/Swiss-Prot:P54538" /translation="MFKIGYRTIKTALGTALAIYISQLLHLQNFASAGIITILCIQIT QKRSLQASWARFSACCLAIAFSYLFFELIGYHPFVIGALLLIFIPITVLLKINEGIVT SSVIILHLYMSGGITPTFIWNEVQLITVGIGVALLMNLYMPSLDRKLIAYRKKIEDNF AVIFAEIERYLLTGEQDWSGKEIPETHQLITEAKNLAYRDVQNHILRYENLHYHYFKM REKQFEIIERLLPKVTSISITVDQGKMIAEFIHDLREAIHPGNTAYKFLKRLADMRKE FEEMPLPATREEFEARAALFHLLGEMEQYLVIKSYFKGIKAQKSLG*" /label="yqjA CDS" gene complement(2158949..2159917) /gene="yqjA" /locus_tag="BSU_23950" /old_locus_tag="BSU23950" /label="yqjA gene" downshifts complement(2158965) /Source="Nicolas_upshifts" /id="D1253" /incds=0 /nref=79 /ntot=223 /MaxReadThrough="2.22356" /MaxDrop="3.94894" /score="1.98299685" /energy="-14.1" /TU="NA" /idTUdmin="U1874" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2159988..2160710) /gene="artR" /locus_tag="BSU_23960" /old_locus_tag="BSU23960" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008; Product type t: transporter" /codon_start=1 /transl_table=11 /product="high affinity arginine ABC transporter (ATP-binding protein)" /protein_id="NP_390276.1" /db_xref="EnsemblGenomes-Gn:BSU23960" /db_xref="EnsemblGenomes-Tr:CAB14327" /db_xref="GOA:P54537" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030679" /db_xref="SubtiList:BG11729" /db_xref="UniProtKB/Swiss-Prot:P54537" /translation="MIKVEKLSKSFGKHEVLKNISTTIAEGEVVAVIGPSGSGKSTFL RCLNLLEKPNGGTITIKDTEITKPKTNTLKVRENIGMVFQHFHLFPHKTVLENIMYAP VNVKKESKQAAQEKAEDLLRKVGLFEKRNDYPNRLSGGQKQRVAIARALAMNPDIMLF DEPTSALDPEMVKEVLQVMKELVETGMTMVIVTHEMGFAKEVADRVLFMDQGMIVEDG NPKEFFMSPKSKRAQDFLEKIL*" /label="artR CDS" gene complement(2159988..2160710) /gene="artR" /locus_tag="BSU_23960" /old_locus_tag="BSU23960" /label="artR gene" downshifts complement(2159999) /Source="Nicolas_upshifts" /id="D1254" /incds=0 /nref=30 /ntot=152 /MaxReadThrough="4.81216" /MaxDrop="4.0342" /score="0.346345754" /energy="-7" /TU="U1874" /idTUdmin="U1874" /TUdmin="-1034" /isTUend="FALSE" /label="downshifts" CDS complement(2160703..2161362) /gene="artQ" /locus_tag="BSU_23970" /old_locus_tag="BSU23970" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="high affinity arginine ABC transporter (permease)" /protein_id="NP_390277.1" /db_xref="EnsemblGenomes-Gn:BSU23970" /db_xref="EnsemblGenomes-Tr:CAB14328" /db_xref="GOA:P54536" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11728" /db_xref="UniProtKB/Swiss-Prot:P54536" /translation="MNLDFSATIPQIPFILEGLAITLKIVVVSAIIGLILGIVLSLCK ISTFRPFIWIADFYTSVFRGTPLVLQLMIVYFGLPQLLGFQIDQFWAAVVALSLNSAA YVSEIIRAGINAIDKGQKEAAVALGVPYGKMMKDLLLPQAFKNISPAIVNELITLTKE SAIVTVIGLGDVMRRAYQAGAATYNYLEPLIIAGLIYYVLVLILTFIGKAVERKLKSN D*" /label="artQ CDS" gene complement(2160703..2161362) /gene="artQ" /locus_tag="BSU_23970" /old_locus_tag="BSU23970" /label="artQ gene" S_feature complement(2161363..2161442) /Source="Nicolas_S_feature" /locus_tag="new_2491949_2492028_c" /HighExp="S1, S2, ferm, MG 15, Fru, Glu, BMM, S3, UNK1, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S909" CDS complement(2161443..2162210) /gene="artP" /locus_tag="BSU_23980" /old_locus_tag="BSU23980" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008; Product type t: transporter" /codon_start=1 /transl_table=11 /product="high affinity arginine ABC transporter binding lipoprotein" /protein_id="NP_390278.1" /db_xref="EnsemblGenomes-Gn:BSU23980" /db_xref="EnsemblGenomes-Tr:CAB14329" /db_xref="GOA:P54535" /db_xref="InterPro:IPR001320" /db_xref="InterPro:IPR001638" /db_xref="InterPro:IPR018313" /db_xref="SubtiList:BG11727" /db_xref="UniProtKB/Swiss-Prot:P54535" /translation="MKKWLLLLVAACITFALTACGSSNSGSESGKKKLIMGTSADYKP FEYKEGDNIVGFDVELAKALAKKAGYEIEVQDMDFNSLITALKSKQVDLVLSGMTPTP ERKKQVDFSDVYYTANHMIVSKKDSGIQSLKDLKGKTVGVQLGSIQEEKGKELSPEYG FKTEDRNRISDLVQEIKSDRFDAAIIEDIVAEGYFKSNDDLQGFVIPDAKAEEAGSAI AFRKDSELTDKFNKALKEMEDNGELEKLKKKWFTGEK*" /label="artP CDS" gene complement(2161443..2162210) /gene="artP" /locus_tag="BSU_23980" /old_locus_tag="BSU23980" /label="artP gene" promotor_-10 complement(2162260..2162279) /Source="Nicolas_upshift_promotors" /id="U1874" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.94105894105894" /psig=1 /xcortree=2912 /SigmaFactorBS="gaaagataagcctaaagataatttttaaaaatagTATTGCAT aaaaatgagaaactGTTTAAAATACAAATTAACGaataaatattcaaatacaccaaaa g" /listShort="artP, S909, artQ, artR, yqjA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2162275) /Source="Nicolas_upshifts" /id="U1874" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.94105894105894" /psig=1 /xcortree=2912 /SigmaFactorBS="gaaagataagcctaaagataatttttaaaaatagTATTGCAT aaaaatgagaaactGTTTAAAATACAAATTAACGaataaatattcaaatacaccaaaa g" /listShort="artP, S909, artQ, artR, yqjA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2162294..2162301) /Source="Nicolas_upshift_promotors" /id="U1874" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.94105894105894" /psig=1 /xcortree=2912 /SigmaFactorBS="gaaagataagcctaaagataatttttaaaaatagTATTGCAT aaaaatgagaaactGTTTAAAATACAAATTAACGaataaatattcaaatacaccaaaa g" /listShort="artP, S909, artQ, artR, yqjA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2162478..2162915) /gene="brxB" /locus_tag="BSU_23990" /old_locus_tag="BSU23990" /experiment="publication(s) with functional evidences, PMID:21749987, 24313874, 28301954" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21749987, 24313874, 28301954; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bacilliredoxin B (de-bacillithiolation)" /protein_id="NP_390279.1" /db_xref="EnsemblGenomes-Gn:BSU23990" /db_xref="EnsemblGenomes-Tr:CAB14330" /db_xref="InterPro:IPR009474" /db_xref="SubtiList:BG11726" /db_xref="UniProtKB/Swiss-Prot:P54534" /translation="MNMDFNLFMNDIVRQARQEITAAGYTELKTAEEVDEALTKKGTT LVMVNSVCGCAGGIARPAAYHSVHYDKRPDQLVTVFAGQDKEATARARDYFEGYPPSS PSFAILKDGKIMKMVERHEIEGHEPMAVVAKLQEAFEEYCEEV*" /label="brxB CDS" gene complement(2162478..2162915) /gene="brxB" /locus_tag="BSU_23990" /old_locus_tag="BSU23990" /label="brxB gene" downshifts complement(2162487) /Source="Nicolas_upshifts" /id="D1255" /incds=0 /nref=252 /ntot=266 /MaxReadThrough="3.9242" /MaxDrop="7.06654" /score="21.489397" /energy="-11.8" /TU="U1875" /idTUdmin="U1875" /TUdmin="-200" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2162939..2162958) /Source="Nicolas_upshift_promotors" /id="U1875" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=1935 /SigmaFactorBS="agtaaacgaagagcaaaaaaagtgcacggcgaagcaaagtCA TTTGCCgatatggacgtttcCTTGCTATCATAAGAACAGAtgatgaaaaaggagaggt c" /listShort="yqiW" /listLong="artP, S909, artQ, artR, yqjA" /label="promotor_-10" upshifts complement(2162960) /Source="Nicolas_upshifts" /id="U1875" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=1935 /SigmaFactorBS="agtaaacgaagagcaaaaaaagtgcacggcgaagcaaagtCA TTTGCCgatatggacgtttcCTTGCTATCATAAGAACAGAtgatgaaaaaggagaggt c" /listShort="yqiW" /listLong="artP, S909, artQ, artR, yqjA" /label="upshifts" promotor_-35 complement(2162973..2162980) /Source="Nicolas_upshift_promotors" /id="U1875" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=1935 /SigmaFactorBS="agtaaacgaagagcaaaaaaagtgcacggcgaagcaaagtCA TTTGCCgatatggacgtttcCTTGCTATCATAAGAACAGAtgatgaaaaaggagaggt c" /listShort="yqiW" /listLong="artP, S909, artQ, artR, yqjA" /label="promotor_-35" promotor_-35 2163013..2163019 /Source="Nicolas_upshift_promotors" /id="U1876" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=198 /SigmaFactorBS="cggcaaatgactttgcttcgccgtgcactttttttgctcttC GTTTACtgcttacagaaaaaGGGGATTATATAACCAGAAgtaaaataaaggagcagtt g" /listShort="bmrU, bmr, bmrR" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2163032 /Source="Nicolas_upshifts" /id="U1876" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=198 /SigmaFactorBS="cggcaaatgactttgcttcgccgtgcactttttttgctcttC GTTTACtgcttacagaaaaaGGGGATTATATAACCAGAAgtaaaataaaggagcagtt g" /listShort="bmrU, bmr, bmrR" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2163034..2163052 /Source="Nicolas_upshift_promotors" /id="U1876" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=198 /SigmaFactorBS="cggcaaatgactttgcttcgccgtgcactttttttgctcttC GTTTACtgcttacagaaaaaGGGGATTATATAACCAGAAgtaaaataaaggagcagtt g" /listShort="bmrU, bmr, bmrR" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2163076..2163969 /gene="bmrU" /locus_tag="BSU_24000" /old_locus_tag="BSU24000" /EC_number="2.7.1.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7961792, 8098708, 10220166, 17114254, 17535816; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lipid kinase BmrU" /protein_id="NP_390280.2" /db_xref="EnsemblGenomes-Gn:BSU24000" /db_xref="EnsemblGenomes-Tr:CAB14331" /db_xref="GOA:P39074" /db_xref="InterPro:IPR001206" /db_xref="InterPro:IPR005218" /db_xref="InterPro:IPR016064" /db_xref="InterPro:IPR017438" /db_xref="SubtiList:BG10302" /db_xref="UniProtKB/Swiss-Prot:P39074" /translation="MSHRKALLIHNGNAGNKNIEKALGAVVPVLSHHLDEVIIKQTKK KDDAYHFCRSIDDSVDTVFILGGDGTIHQCINAISALERKPAVGILPGGTCNDFSRVL GIPQNLAKAAEALMAGKKTSVDVCQMNDRYFLNFWGIGLIAETSNQINETEKALLGKI SYFTSALRTVSSAASFPMTLKIDGEEIKEEAVMLLVMNGQYIGTNRIPLPDASIEDGL LDVLICRNTNLTALRELMSMEQGSIDRFTGELSYVQASRIEIETDTAKKADMDGEVYT HTPAVIQVLPQHIDMLVPANE*" /label="bmrU CDS" gene 2163076..2163969 /gene="bmrU" /locus_tag="BSU_24000" /old_locus_tag="BSU24000" /label="bmrU gene" promotor_-35 2164002..2164009 /Source="Nicolas_upshift_promotors" /id="U1877" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.97002997002997" /psig="0.993006993006993" /xcortree=1530 /SigmaFactorBS="tcataaggctttagaaagattttgcaaatCCGTTGACtctcc cctaggaggaGGTCTTACAGTATAAGGGATacacacttgaaaaaggggaagtcatatg g" /listShort="bmr, bmrR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2164025..2164044 /Source="Nicolas_upshift_promotors" /id="U1877" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.97002997002997" /psig="0.993006993006993" /xcortree=1530 /SigmaFactorBS="tcataaggctttagaaagattttgcaaatCCGTTGACtctcc cctaggaggaGGTCTTACAGTATAAGGGATacacacttgaaaaaggggaagtcatatg g" /listShort="bmr, bmrR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2164033 /Source="Nicolas_upshifts" /id="U1877" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.97002997002997" /psig="0.993006993006993" /xcortree=1530 /SigmaFactorBS="tcataaggctttagaaagattttgcaaatCCGTTGACtctcc cctaggaggaGGTCTTACAGTATAAGGGATacacacttgaaaaaggggaagtcatatg g" /listShort="bmr, bmrR" /GFF_Attribute="listLong" /label="upshifts" CDS 2164070..2165239 /gene="bmr" /locus_tag="BSU_24010" /old_locus_tag="BSU24010" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10200972, 10961951, 11321573, 15849754, 16850406, 25756668" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10200972, 10961951, 11321573, 15849754, 16850406, 25756668; Product type t : transporter" /codon_start=1 /transl_table=11 /product="multidrug-efflux transporter" /protein_id="NP_390281.2" /db_xref="EnsemblGenomes-Gn:BSU24010" /db_xref="EnsemblGenomes-Tr:CAB14332" /db_xref="GOA:P33449" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10303" /db_xref="UniProtKB/Swiss-Prot:P33449" /translation="MEKKNITLTILLTNLFIAFLGIGLVIPVTPTIMNELHLSGTAVG YMVACFAITQLIVSPIAGRWVDRFGRKIMIVIGLLFFSVSEFLFGIGKTVEMLFISRM LGGISAAFIMPGVTAFIADITTIKTRPKALGYMSAAISTGFIIGPGIGGFLAEVHSRL PFFFAAAFALLAAILSILTLREPERNPENQEIKGQKTGFKRIFAPMYFIAFLIILISS FGLASFESLFALFVDHKFGFTASDIAIMITGGAIVGAITQVVLFDRFTRWFGEIHLIR YSLILSTSLVFLLTTVHSYVAILLVTVTVFVGFDLMRPAVTTYLSKIAGNEQGFAGGM NSMFTSIGNVFGPIIGGMLFDIDVNYPFYFATVTLAIGIALTIAWKAPAHLKAST*" /label="bmr CDS" gene 2164070..2165239 /gene="bmr" /locus_tag="BSU_24010" /old_locus_tag="BSU24010" /label="bmr gene" downshifts 2165222 /Source="Nicolas_upshifts" /id="D1256" /incds=0 /nref=6 /ntot=31 /MaxReadThrough="4.82186" /MaxDrop="5.02667" /score="-1.94257488" /energy="-18" /TU="U1876,U1877" /idTUdmin="U1876" /TUdmin="-924" /isTUend="FALSE" /label="downshifts" CDS 2165312..2166148 /gene="bmrR" /locus_tag="BSU_24020" /old_locus_tag="BSU24020" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11201751, 11839496, 12682015, 14985361, 18658145, 21690368" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11201751, 11839496, 12682015, 14985361, 18658145, 21690368; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (MerR family)" /protein_id="NP_390282.2" /db_xref="EnsemblGenomes-Gn:BSU24020" /db_xref="EnsemblGenomes-Tr:CAB14333" /db_xref="GOA:P39075" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="InterPro:IPR011256" /db_xref="InterPro:IPR029442" /db_xref="PDB:1BOW" /db_xref="PDB:1EXI" /db_xref="PDB:1EXJ" /db_xref="PDB:1R8E" /db_xref="PDB:2BOW" /db_xref="PDB:3D6Y" /db_xref="PDB:3D6Z" /db_xref="PDB:3D70" /db_xref="PDB:3D71" /db_xref="PDB:3IAO" /db_xref="PDB:3Q1M" /db_xref="PDB:3Q2Y" /db_xref="PDB:3Q3D" /db_xref="PDB:3Q5P" /db_xref="PDB:3Q5R" /db_xref="PDB:3Q5S" /db_xref="SubtiList:BG10304" /db_xref="UniProtKB/Swiss-Prot:P39075" /translation="MKESYYSIGEVSKLANVSIKALRYYDKIDLFKPAYVDPDTSYRY YTDSQLIHLDLIKSLKYIGTPLEEMKKAQDLEMEELFAFYTEQERQIREKLDFLSALE QTISLVKKRMKRQMEYPALGEVFVLDEEEIRIIQTEAEGIGPENVLNASYSKLKKFIE SADGFTNNSYGATFSFQPYTSIDEMTYRHIFTPVLTNKQISSITPDMEITTIPKGRYA CIAYNFSPEHYFLNLQKLIKYIADRQLTVVSDVYELIIPIHYSPKKQEEYRVEMKIRI AE*" /label="bmrR CDS" gene 2165312..2166148 /gene="bmrR" /locus_tag="BSU_24020" /old_locus_tag="BSU24020" /label="bmrR gene" downshifts 2166146 /Source="Nicolas_upshifts" /id="D1257" /incds=0 /nref=5 /ntot=156 /MaxReadThrough="4.1979" /MaxDrop="4.72542" /score="5.00815505" /energy="-15.7" /TU="NA" /idTUdmin="U1876" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2166210) /Source="Nicolas_upshifts" /id="D1258" /incds=0 /nref=15 /ntot=247 /MaxReadThrough="3.01431" /MaxDrop="6.04069" /score="8.5296919" /energy="-16.8" /TU="U1879" /idTUdmin="U1878" /TUdmin="-10" /isTUend="TRUE" /label="downshifts" CDS complement(2166210..2167484) /gene="bkdB" /locus_tag="BSU_24030" /old_locus_tag="BSU24030" /EC_number="2.3.1.168" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10094682, 12427936, 15241682, 22720735, 28371347" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094682, 12427936, 15241682, 22720735, 28371347; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branched-chain alpha-keto acid dehydrogenase E2 subunit (lipoamide acyltransferase)" /protein_id="NP_390283.1" /db_xref="EnsemblGenomes-Gn:BSU24030" /db_xref="EnsemblGenomes-Tr:CAB14334" /db_xref="GOA:P37942" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR001078" /db_xref="InterPro:IPR003016" /db_xref="InterPro:IPR004167" /db_xref="InterPro:IPR011053" /db_xref="InterPro:IPR036625" /db_xref="SubtiList:BG10305" /db_xref="UniProtKB/Swiss-Prot:P37942" /translation="MAIEQMTMPQLGESVTEGTISKWLVAPGDKVNKYDPIAEVMTDK VNAEVPSSFTGTITELVGEEGQTLQVGEMICKIETEGANPAEQKQEQPAASEAAENPV AKSAGAADQPNKKRYSPAVLRLAGEHGIDLDQVTGTGAGGRITRKDIQRLIETGGVQE QNPEELKTAAPAPKSASKPEPKEETSYPASAAGDKEIPVTGVRKAIASNMKRSKTEIP HAWTMMEVDVTNMVAYRNSIKDSFKKTEGFNLTFFAFFVKAVAQALKEFPQMNSMWAG DKIIQKKDINISIAVATEDSLFVPVIKNADEKTIKGIAKDITGLAKKVRDGKLTADDM QGGTFTVNNTGSFGSVQSMGIINYPQAAILQVESIVKRPVVMDNGMIAVRDMVNLCLS LDHRVLDGLVCGRFLGRVKQILESIDEKTSVY*" /label="bkdB CDS" gene complement(2166210..2167484) /gene="bkdB" /locus_tag="BSU_24030" /old_locus_tag="BSU24030" /label="bkdB gene" CDS complement(2167507..2168490) /gene="bkdAB" /locus_tag="BSU_24040" /old_locus_tag="BSU24040" /EC_number="1.2.4.4" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10094682, 12427936, 15241682, 28371347" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094682, 12427936, 15241682, 28371347; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branched-chain alpha-keto acid dehydrogenase E1 subunit" /protein_id="NP_390284.1" /db_xref="EnsemblGenomes-Gn:BSU24040" /db_xref="EnsemblGenomes-Tr:CAB14335" /db_xref="GOA:P37941" /db_xref="InterPro:IPR005475" /db_xref="InterPro:IPR009014" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR033248" /db_xref="SubtiList:BG10306" /db_xref="UniProtKB/Swiss-Prot:P37941" /translation="MSVMSYIDAINLAMKEEMERDSRVFVLGEDVGRKGGVFKATAGL YEQFGEERVMDTPLAESAIAGVGIGAAMYGMRPIAEMQFADFIMPAVNQIISEAAKIR YRSNNDWSCPIVVRAPYGGGVHGALYHSQSVEAIFANQPGLKIVMPSTPYDAKGLLKA AVRDEDPVLFFEHKRAYRLIKGEVPADDYVLPIGKADVKREGDDITVITYGLCVHFAL QAAERLEKDGISAHVVDLRTVYPLDKEAIIEAASKTGKVLLVTEDTKEGSIMSEVAAI ISEHCLFDLDAPIKRLAGPDIPAMPYAPTMEKYFMVNPDKVEAAMRELAEF*" /label="bkdAB CDS" gene complement(2167507..2168490) /gene="bkdAB" /locus_tag="BSU_24040" /old_locus_tag="BSU24040" /label="bkdAB gene" CDS complement(2168504..2169496) /gene="bkdAA" /locus_tag="BSU_24050" /old_locus_tag="BSU24050" /EC_number="1.2.4.4" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10094682, 12427936, 15241682, 22720735, 28371347" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094682, 12427936, 15241682, 22720735, 28371347; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branched-chain alpha-keto acid dehydrogenase E1 subunit" /protein_id="NP_390285.1" /db_xref="EnsemblGenomes-Gn:BSU24050" /db_xref="EnsemblGenomes-Tr:CAB14336" /db_xref="GOA:P37940" /db_xref="InterPro:IPR001017" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR034616" /db_xref="SubtiList:BG10307" /db_xref="UniProtKB/Swiss-Prot:P37940" /translation="MSTNRHQALGLTDQEAVDMYRTMLLARKIDERMWLLNRSGKIPF VISCQGQEAAQVGAAFALDREMDYVLPYYRDMGVVLAFGMTAKDLMMSGFAKAADPNS GGRQMPGHFGQKKNRIVTGSSPVTTQVPHAVGIALAGRMEKKDIAAFVTFGEGSSNQG DFHEGANFAAVHKLPVIFMCENNKYAISVPYDKQVACENISDRAIGYGMPGVTVNGND PLEVYQAVKEARERARRGEGPTLIETISYRLTPHSSDDDDSSYRGREEVEEAKKSDPL LTYQAYLKETGLLSDEIEQTMLDEIMAIVNEATDEAENAPYAAPESALDYVYAK*" /label="bkdAA CDS" gene complement(2168504..2169496) /gene="bkdAA" /locus_tag="BSU_24050" /old_locus_tag="BSU24050" /label="bkdAA gene" CDS complement(2169518..2170942) /gene="lpdV" /locus_tag="BSU_24060" /old_locus_tag="BSU24060" /EC_number="1.8.1.4" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10094682, 12427936, 15241682, 28371347" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094682, 12427936, 15241682, 28371347; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branched-chain alpha-keto acid dehydrogenase E3 subunit (dihydrolipoamide dehydrogenase)" /protein_id="NP_390286.2" /db_xref="EnsemblGenomes-Gn:BSU24060" /db_xref="EnsemblGenomes-Tr:CAB14337" /db_xref="GOA:P54533" /db_xref="InterPro:IPR001100" /db_xref="InterPro:IPR004099" /db_xref="InterPro:IPR006258" /db_xref="InterPro:IPR012999" /db_xref="InterPro:IPR016156" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG11725" /db_xref="UniProtKB/Swiss-Prot:P54533" /translation="MATEYDVVILGGGTGGYVAAIRAAQLGLKTAVVEKEKLGGTCLH KGCIPSKALLRSAEVYRTAREADQFGVETAGVSLNFEKVQQRKQAVVDKLAAGVNHLM KKGKIDVYTGYGRILGPSIFSPLPGTISVERGNGEENDMLIPKQVIIATGSRPRMLPG LEVDGKSVLTSDEALQMEELPQSIIIVGGGVIGIEWASMLHDFGVKVTVIEYADRILP TEDLEISKEMESLLKKKGIQFITGAKVLPDTMTKTSDDISIQAEKDGETVTYSAEKML VSIGRQANIEGIGLENTDIVTENGMISVNESCQTKESHIYAIGDVIGGLQLAHVASHE GIIAVEHFAGLNPHPLDPTLVPKCIYSSPEAASVGLTEDEAKANGHNVKIGKFPFMAI GKALVYGESDGFVKIVADRDTDDILGVHMIGPHVTDMISEAGLAKVLDATPWEVGQTI HPHPTLSEAIGEAALAADGKAIHF*" /label="lpdV CDS" gene complement(2169518..2170942) /gene="lpdV" /locus_tag="BSU_24060" /old_locus_tag="BSU24060" /label="lpdV gene" CDS complement(2170963..2172054) /gene="buk" /locus_tag="BSU_24070" /old_locus_tag="BSU24070" /EC_number="2.7.2.-" /EC_number="2.7.2.7" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10094682, 12427936, 15241682" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094682, 12427936, 15241682; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branched-chain fatty-acid kinase" /protein_id="NP_390287.2" /db_xref="EnsemblGenomes-Gn:BSU24070" /db_xref="EnsemblGenomes-Tr:CAB14338" /db_xref="GOA:P54532" /db_xref="InterPro:IPR000890" /db_xref="InterPro:IPR011245" /db_xref="InterPro:IPR023865" /db_xref="SubtiList:BG11724" /db_xref="UniProtKB/Swiss-Prot:P54532" /translation="MKVLHDEKRILTINPGSTSTKIGVFHNERSIFEKTLRHNIEELQ RFDRIIDQYEFRKNHILETLHEQGINISKFDAVCARGGLLRPIEGGTYVVNDEMIEDL KSGYAGQHASNLGGIIAREIADGLNIPSYIVDPVVVDEMSVLAKVSGMPEIERKSIFH ALNQKAVARKAAASLGKRYENMKMIITHMGGGITIGVHDRGRVVDVNNGLHGEGPFSP ERAGTVPAGDLVDLCFSGEYTKEEIMKKLVGTGGLLGYLGTNDAVKVEQMIQGGDEKA RFIYDAMAYQVAKEIGAASAALKGEVEAIVLTGGLAYGKSFVSAIRSYIDWISDVLVY PGENELQSLAQGALRVLQGEEQSKQYRIE*" /label="buk CDS" gene complement(2170963..2172054) /gene="buk" /locus_tag="BSU_24070" /old_locus_tag="BSU24070" /label="buk gene" CDS complement(2172073..2173167) /gene="bcd" /locus_tag="BSU_24080" /old_locus_tag="BSU24080" /EC_number="1.4.1.8" /EC_number="1.4.1.-" /EC_number="1.4.1.9" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:4204435, 10094682, 12427936, 15241682, 20935095, 21856856, 22720735, 28165735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4204435, 10094682, 12427936, 15241682, 20935095, 21856856, 22720735, 28165735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branched-chain amino acid dehydrogenase" /protein_id="NP_390288.1" /db_xref="EnsemblGenomes-Gn:BSU24080" /db_xref="EnsemblGenomes-Tr:CAB14339" /db_xref="GOA:P54531" /db_xref="InterPro:IPR006095" /db_xref="InterPro:IPR006096" /db_xref="InterPro:IPR006097" /db_xref="InterPro:IPR016211" /db_xref="InterPro:IPR033524" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11723" /db_xref="UniProtKB/Swiss-Prot:P54531" /translation="MELFKYMEKYDYEQLVFCQDEQSGLKAIIAIHDTTLGPALGGTR MWTYENEEAAIEDALRLARGMTYKNAAAGLNLGGGKTVIIGDPRKDKNEEMFRAFGRY IQGLNGRYITAEDVGTTVEDMDIIHDETDYVTGISPAFGSSGNPSPVTAYGVYRGMKA AAKAAFGTDSLEGKTIAVQGVGNVAYNLCRHLHEEGANLIVTDINKQSVQRAVEDFGA RAVDPDDIYSQDCDIYAPCALGATINDDTIKQLKAKVIAGAANNQLKETRHGDQIHEM GIVYAPDYVINAGGVINVADELYGYNAERALKKVEGIYGNIERVLEISQRDGIPAYLA ADRLAEERIERMRRSRSQFLQNGHSVLSRR*" /label="bcd CDS" gene complement(2172073..2173167) /gene="bcd" /locus_tag="BSU_24080" /old_locus_tag="BSU24080" /label="bcd gene" CDS complement(2173179..2174078) /gene="ptb" /locus_tag="BSU_24090" /old_locus_tag="BSU24090" /EC_number="2.3.1.19" /EC_number="2.3.1.-" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10094682, 12427936, 15241682, 22720735, 28165735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094682, 12427936, 15241682, 22720735, 28165735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphate BCFA and butyryl coenzyme A transferase" /protein_id="NP_390289.2" /db_xref="EnsemblGenomes-Gn:BSU24090" /db_xref="EnsemblGenomes-Tr:CAB14340" /db_xref="GOA:P54530" /db_xref="InterPro:IPR002505" /db_xref="InterPro:IPR012147" /db_xref="InterPro:IPR014079" /db_xref="SubtiList:BG11722" /db_xref="UniProtKB/Swiss-Prot:P54530" /translation="MKLKDLIGKASIHKNKTIAVAHAEDEEVIRAVKLAAEHLSARFL LTGDSKKLNELTSSMQGHQVEIVHANTPEESAKLAVRAVHHKTADVLMKGNVPTSVLL KAVLNRQEGLRSASVLSHVAVFDIPDFDRLMFVTDSAMNIAPSLEELRQILQNAVHVA HAVGNNMPKAAALAAVETVNPKMEATVNAAALAQMYKRGQIKGCIVDGPLALDNAVSQ IAAAQKKISGDVAGNADILLVPTIEAGNILYKSLIYFAKASVAAVITGAKAPIALTSR ADSAENKLYSIALAICASEEYTH*" /label="ptb CDS" gene complement(2173179..2174078) /gene="ptb" /locus_tag="BSU_24090" /old_locus_tag="BSU24090" /label="ptb gene" misc_feature complement(2174114..2174133) /Source="Nicolas_upshift_promotors" /id="U1878" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.764235764235764" /psig="0.764235764235764" /xcortree=340 /SigmaFactorBS="tgcacgaatgtttcggtatacctggtatgacagcacccttaa gagcTGGCATGGAACTTGCATAATaaaaggcggagtcgaaacaagaaaggtggtaaca g" /listShort="ptb, bcd, buk, lpdV, bkdAA, bkdAB, bkdB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2174119) /Source="Nicolas_upshifts" /id="U1878" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.764235764235764" /psig="0.764235764235764" /xcortree=340 /SigmaFactorBS="tgcacgaatgtttcggtatacctggtatgacagcacccttaa gagcTGGCATGGAACTTGCATAATaaaaggcggagtcgaaacaagaaaggtggtaaca g" /listShort="ptb, bcd, buk, lpdV, bkdAA, bkdAB, bkdB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2174121..2174202) /Source="Nicolas_S_feature" /locus_tag="new_2504707_2504788_c" /HighExp="Cold, LBGtran, G180, Lbexp, G135, G150, LBGexp, Diami, Oxctl, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S910" CDS complement(2174203..2176281) /gene="bkdR" /locus_tag="BSU_24100" /old_locus_tag="BSU24100" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10094682, 12427936, 15241682, 16585774" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094682, 12427936, 15241682, 16585774; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator" /protein_id="NP_390290.1" /db_xref="EnsemblGenomes-Gn:BSU24100" /db_xref="EnsemblGenomes-Tr:CAB14341" /db_xref="GOA:P54529" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR002078" /db_xref="InterPro:IPR002197" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR013767" /db_xref="InterPro:IPR025662" /db_xref="InterPro:IPR025943" /db_xref="InterPro:IPR025944" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11721" /db_xref="UniProtKB/Swiss-Prot:P54529" /translation="MQKVLIVGAGKRGTALLHILIKTAIIDIIAVVDKDPEAPGLKEA EQYGIAVSSDWKPYIQQKPDIVIHTTGDQAVFDELLQRKHEDTIVMPGKMAYIVFQLM EEKQHLIQMLKEQTYKYDRIFNSTHDGMIFIDINEEIILFNHMAEKMVGKKREEVIGR PIKEVIPSTKMPRILKTRVPEYNQKQLLGDHLQIVTTRLPIIDEGGRLLGALCVFKDI TDAVELAEEVTNLKQVRTMLEAIIQSSDEAISVVDENGIGLLINKAYTKMTGLSEKEV IGKPANTDISEGESMHLKVLETRRPVRGVRMKVGPNEKEVIVNVAPVIVDGILKGSVG VIHDVSEIKMLTAELNRARQIIRTLEAKYTFDDIIGKSEQMLVALEQAKLGAKTPATI LLRGESGTGKELFAHAIHNESDRKYNKFIRVNCAALSENLLESELFGYEDGAFSGAKR GGKKGLFEEANNGSIFLDEIGELTQNMQAKLLRVLQEKEIVRVGGTKAIPVNVRVIAA TNVNIEKAMADGTFREDLYYRINRYPISIPPLRQRLEDIEALSVRLIQKINRDYGRNV KGLSQQALRALSAYHWPGNVRELENVLGRAMIFLNPHMEWIEKDHLPVFELEQKENDT DQGTGFDFPDIEGEKLSVAVEKFEAHLIQQTLEKHHFNRTKTAKALGVSIRNLYYKMD KYGLANEGMQ*" /label="bkdR CDS" gene complement(2174203..2176281) /gene="bkdR" /locus_tag="BSU_24100" /old_locus_tag="BSU24100" /label="bkdR gene" promotor_-10 complement(2176341..2176360) /Source="Nicolas_upshift_promotors" /id="U1879" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=2683 /SigmaFactorBS="ttatcttttcatttcctttattgtccagcggaaaaaatATTT tgtcaagagaagaaaaCGTGGTAACATAGGGTTGTGcaaattattgcaacggaataaa t" /listShort="bkdR, S910, ptb, bcd, buk, lpdV, bkdAA, bkdAB, bkdB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2176358) /Source="Nicolas_upshifts" /id="U1879" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=2683 /SigmaFactorBS="ttatcttttcatttcctttattgtccagcggaaaaaatATTT tgtcaagagaagaaaaCGTGGTAACATAGGGTTGTGcaaattattgcaacggaataaa t" /listShort="bkdR, S910, ptb, bcd, buk, lpdV, bkdAA, bkdAB, bkdB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2176368..2176375 /Source="Nicolas_upshift_promotors" /id="U1880" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.63036963036963" /psig="0.998001998001998" /xcortree=386 /SigmaFactorBS="atttgcacaaccctatgttaccacgttttcttCTCTTGACaa aatattttttcCGCTGGACAATAAAGGAAATgaaaagataaaggggttttctgaagat g" /listShort="yqzF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2176377..2176380) /Source="Nicolas_upshift_promotors" /id="U1879" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=2683 /SigmaFactorBS="ttatcttttcatttcctttattgtccagcggaaaaaatATTT tgtcaagagaagaaaaCGTGGTAACATAGGGTTGTGcaaattattgcaacggaataaa t" /listShort="bkdR, S910, ptb, bcd, buk, lpdV, bkdAA, bkdAB, bkdB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2176389..2176408 /Source="Nicolas_upshift_promotors" /id="U1880" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.63036963036963" /psig="0.998001998001998" /xcortree=386 /SigmaFactorBS="atttgcacaaccctatgttaccacgttttcttCTCTTGACaa aatattttttcCGCTGGACAATAAAGGAAATgaaaagataaaggggttttctgaagat g" /listShort="yqzF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2176396 /Source="Nicolas_upshifts" /id="U1880" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.63036963036963" /psig="0.998001998001998" /xcortree=386 /SigmaFactorBS="atttgcacaaccctatgttaccacgttttcttCTCTTGACaa aatattttttcCGCTGGACAATAAAGGAAATgaaaagataaaggggttttctgaagat g" /listShort="yqzF" /GFF_Attribute="listLong" /label="upshifts" CDS 2176434..2176670 /gene="yqzF" /locus_tag="BSU_24110" /old_locus_tag="BSU24110" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390291.1" /db_xref="EnsemblGenomes-Gn:BSU24110" /db_xref="EnsemblGenomes-Tr:CAB14342" /db_xref="GOA:O32015" /db_xref="InterPro:IPR020138" /db_xref="SubtiList:BG13772" /db_xref="UniProtKB/Swiss-Prot:O32015" /translation="MSRLLALLILVIPGAISALGIKLMRDTLFGHTIKPFSALWLQGL SGFIFFAIGLYVLAGFILYRDRKRNQVSPRFRKR*" /label="yqzF CDS" gene 2176434..2176670 /gene="yqzF" /locus_tag="BSU_24110" /old_locus_tag="BSU24110" /label="yqzF gene" downshifts 2176661 /Source="Nicolas_upshifts" /id="D1259" /incds=0 /nref=64 /ntot=230 /MaxReadThrough="2.80342" /MaxDrop="5.10794" /score="42.7247617" /energy="-11.9" /TU="NA" /idTUdmin="U1880" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2176712..2177617) /gene="mmgF" /locus_tag="BSU_24120" /old_locus_tag="BSU24120" /EC_number="4.1.3.30" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12706720, 17274076, 28956599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12706720, 17274076, 28956599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-methylisocitrate lyase" /protein_id="NP_390292.1" /db_xref="EnsemblGenomes-Gn:BSU24120" /db_xref="EnsemblGenomes-Tr:CAB14343" /db_xref="GOA:P54528" /db_xref="InterPro:IPR012695" /db_xref="InterPro:IPR015813" /db_xref="InterPro:IPR018523" /db_xref="SubtiList:BG11720" /db_xref="UniProtKB/Swiss-Prot:P54528" /translation="MSWIVNKQSSQEELAGRFRKLMSAPDILQIPGAHDGMAALLAKE AGFSAIYLSGAAYTASRGLPDLGIITSAEIAERAKDLVRAADLPLLVDIDTGFGGVLN AARTAREMLEARVAAVQMEDQQLPKKCGHLNGKQLVPIKEMAQKIKAIKQAAPSLIVV ARTDARAQEGLDAAIKRSEAYIEAGADAIFPEALQAENEFRQFAERIPVPLLANMTEF GKTPYYRADEFEDMGFHMVIYPVTSLRAAAKACERMFGLMKEHGSQKEGLHDMQTRKE LYDTISYYDYEALDKTIAKTVLPDE*" /label="mmgF CDS" gene complement(2176712..2177617) /gene="mmgF" /locus_tag="BSU_24120" /old_locus_tag="BSU24120" /label="mmgF gene" downshifts complement(2176715) /Source="Nicolas_upshifts" /id="D1260" /incds=0 /nref=29 /ntot=69 /MaxReadThrough="2.12559" /MaxDrop="5.62" /score="33.814061" /energy="-11.9" /TU="NA" /idTUdmin="U1884" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2177635..2179053) /gene="mmgE" /locus_tag="BSU_24130" /old_locus_tag="BSU24130" /EC_number="4.2.1.79" /EC_number="4.2.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17274076, 28956599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17274076, 28956599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-methylcitrate dehydratase (promiscuous)" /protein_id="NP_390293.2" /db_xref="EnsemblGenomes-Gn:BSU24130" /db_xref="EnsemblGenomes-Tr:CAB14344" /db_xref="GOA:P45859" /db_xref="InterPro:IPR005656" /db_xref="InterPro:IPR012705" /db_xref="InterPro:IPR036148" /db_xref="SubtiList:BG11323" /db_xref="UniProtKB/Swiss-Prot:P45859" /translation="MPKTDRVIEEITDYVLEKEITSAEAYTTAGHVLLDTLGCGILAL RYPECTKLLGPIVPGTTVPNGSKVPGTSYVLDPVRAAFNIGCMIRWLDYNDTWLAAEW GHPSDNLGGILAAADYVSRVRLSEGKEPLTVRDVLEMMIKAHEIQGVLALENSLNRVG LDHVLFVKVATTAVAAKLLGGGREEIKNALSNAWIDNAALRTYRHSPNTGSRKSWAAG DATSRGVHLALMSLKGEMGYPTALSAPGWGFQDVLFNKKEIKLARPLDAYVMENVLFK VSYPAEFHAQTAAESAVILHPQVKNRIDEIDRVVIRTHESAIRIIDKKGPLHNPADRD HCLQYITAIGLLFGDITAQHYEAETANDPRIDKLRDKMEVTENKTYTEDYLKPDKRSI SNAVQVHFKDGTSTEMVECEFPLGHRFRREEAVPKLLEKFSDNLKTHFPDKQHKHIYE RCTSYETLQTMRVNEFVDMFCM*" /label="mmgE CDS" gene complement(2177635..2179053) /gene="mmgE" /locus_tag="BSU_24130" /old_locus_tag="BSU24130" /label="mmgE gene" misc_feature complement(2177930..2177949) /Source="Nicolas_upshift_promotors" /id="U1881" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.881118881118881" /psig="0.997002997002997" /xcortree=616 /SigmaFactorBS="tatcaccgcacagcattatgaagctgaaacagcgaatgatcc gagaatagataaacttCGTGATAAAATGGAAGTGACtgaaaataaaacatataccgag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2177947) /Source="Nicolas_upshifts" /id="U1881" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.881118881118881" /psig="0.997002997002997" /xcortree=616 /SigmaFactorBS="tatcaccgcacagcattatgaagctgaaacagcgaatgatcc gagaatagataaacttCGTGATAAAATGGAAGTGACtgaaaataaaacatataccgag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2179068..2180186) /gene="mmgD" /locus_tag="BSU_24140" /old_locus_tag="BSU24140" /EC_number="2.3.3.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8759838, 17274076, 28956599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8759838, 17274076, 28956599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional citrate synthase/2-methylcitrate synthase" /protein_id="NP_390294.1" /db_xref="EnsemblGenomes-Gn:BSU24140" /db_xref="EnsemblGenomes-Tr:CAB14345" /db_xref="GOA:P45858" /db_xref="InterPro:IPR002020" /db_xref="InterPro:IPR016142" /db_xref="InterPro:IPR019810" /db_xref="InterPro:IPR024176" /db_xref="InterPro:IPR036969" /db_xref="SubtiList:BG11322" /db_xref="UniProtKB/Swiss-Prot:P45858" /translation="MEEKQHYSPGLDGVIAAETHISYLDTQSSQILIRGYDLIELSET KSYLELVHLLLEGRLPEESEMETLERKINSASSLPADHLRLLELLPEDTHPMDGLRTG LSALAGYDRQIDDRSPSANKERAYQLLGKMPALTAASYRIINKKEPILPLQTLSYSAN FLYMMTGKLPSSLEEQIFDRSLVLYSEHEMPNSTFAARVIASTHSDLYGALTGAVASL KGNLHGGANEAVMYLLLEAKTTSDFEQLLQTKLKRKEKIMGFGHRVYMKKMDPRALMM KEALQQLCDKAGDHRLYEMCEAGERLMEKEKGLYPNLDYYAAPVYWMLGIPIPLYTPI FFSARTSGLCAHVIEQHANNRLFRPRVSYMGPRYQTKS*" /label="mmgD CDS" gene complement(2179068..2180186) /gene="mmgD" /locus_tag="BSU_24140" /old_locus_tag="BSU24140" /label="mmgD gene" CDS complement(2180220..2181359) /gene="mmgC" /locus_tag="BSU_24150" /old_locus_tag="BSU24150" /EC_number="1.3.99.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:28956599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 28956599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="propionyl-CoA dehydrogenase subunit" /protein_id="NP_390295.2" /db_xref="EnsemblGenomes-Gn:BSU24150" /db_xref="EnsemblGenomes-Tr:CAB14346" /db_xref="GOA:P45857" /db_xref="InterPro:IPR006089" /db_xref="InterPro:IPR006091" /db_xref="InterPro:IPR009075" /db_xref="InterPro:IPR009100" /db_xref="InterPro:IPR013786" /db_xref="InterPro:IPR036250" /db_xref="InterPro:IPR037069" /db_xref="PDB:5LNX" /db_xref="SubtiList:BG11321" /db_xref="UniProtKB/Swiss-Prot:P45857" /translation="MHVTQEQVMMRKMVRDFARKEIAPAAEIMEKTDEFPFQLIKKMG KHGLMGIPVPEQYGGAGADVVSYILAIHEISRISAAVGVILSVHTSVGTNPILYFGNE EQKMKYIPNLASGDHLGAFALTEPHSGSDAGSLRTTAIKKNGKYLLNGSKIFITNGGA ADIYITFALTAPDQGRHGISAFIVEKNTPGFTVGKKERKLGLYGSNTTELIFDNAEVP EANLLGKEGDGFHIAMANLNVGRIGIAAQALGIAEAALEHAVDYAKQRVQFGRPIAAN QGISFKLADMATRAEAARHLVYHAADLHNRGLNCGKEASMAKQFASDAAVKAALDAVQ IYGGYGYMKDYPVERLLRDAKVTQIYEGTNEIQRLIISKYLLGGT*" /label="mmgC CDS" gene complement(2180220..2181359) /gene="mmgC" /locus_tag="BSU_24150" /old_locus_tag="BSU24150" /label="mmgC gene" CDS complement(2181387..2182250) /gene="mmgB" /locus_tag="BSU_24160" /old_locus_tag="BSU24160" /EC_number="1.1.1.157" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8759838, 18461320, 28956599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8759838, 18461320, 28956599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-hydroxybutyryl-CoA dehydrogenase" /protein_id="NP_390296.2" /db_xref="EnsemblGenomes-Gn:BSU24160" /db_xref="EnsemblGenomes-Tr:CAB14347" /db_xref="GOA:P45856" /db_xref="InterPro:IPR006108" /db_xref="InterPro:IPR006176" /db_xref="InterPro:IPR006180" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR022694" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11320" /db_xref="UniProtKB/Swiss-Prot:P45856" /translation="MEIKQIMVAGAGQMGSGIAQTAADAGFYVRMYDVNPEAAEAGLK RLKKQLARDAEKGKRTETEVKSVINRISISQTLEEAEHADIVIEAIAENMAAKTEMFK TLDRICPPHTILASNTSSLPITEIAAVTNRPQRVIGMHFMNPVPVMKLVEVIRGLATS EETALDVMALAEKMGKTAVEVNDFPGFVSNRVLLPMINEAIYCVYEGVAKPEAIDEVM KLGMNHPMGPLALADFIGLDTCLSIMEVLHSGLGDSKYRPCPLLRKYVKAGWLGKKSG RGFYDYEEKTS*" /label="mmgB CDS" gene complement(2181387..2182250) /gene="mmgB" /locus_tag="BSU_24160" /old_locus_tag="BSU24160" /label="mmgB gene" CDS complement(2182275..2183456) /gene="mmgA" /locus_tag="BSU_24170" /old_locus_tag="BSU24170" /EC_number="2.3.1.9" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16352833, 18246303, 19016856, 28956599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16352833, 18246303, 19016856, 28956599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="degradative acetoacetyl-CoA thiolase" /protein_id="NP_390297.1" /db_xref="EnsemblGenomes-Gn:BSU24170" /db_xref="EnsemblGenomes-Tr:CAB14348" /db_xref="GOA:P45855" /db_xref="InterPro:IPR002155" /db_xref="InterPro:IPR016039" /db_xref="InterPro:IPR020610" /db_xref="InterPro:IPR020613" /db_xref="InterPro:IPR020615" /db_xref="InterPro:IPR020616" /db_xref="InterPro:IPR020617" /db_xref="PDB:5LP7" /db_xref="SubtiList:BG11319" /db_xref="UniProtKB/Swiss-Prot:P45855" /translation="MRKTVIVSAARTPFGKFGGVLKEVKAAELGGIVMKEALQQAGVS GDDVEGNVMGMVVQAGSGQIPSRQAARLAGMPWSVPSETLNKVCASGLRAVTLCDQMI RAQDADILVAGGMESMSNIPYAVPAGRWGARMGDGELRDLMVYDGLTCAFDEVHMAVH GNTAAKEYAISRREQDEWALRSHARAAKAADEGKFQDEIVPVNWIGRKGKPNVVDKDE AIRRDTSLDQLAKLAPIYASDGSITAGNAPGVNDGAGAFVLMSEEKAAELGKRPLATI LGFSTTGMPAHELAAAPGFAINKLLKKNGLTVQDIDLFEVNEAFASVVLTCEKIVGFD LEKVNVNGGAIALGHPIGASGARILMTLVYELKRRGGGLGVAAICSGAAQGDAVLVQV H*" /label="mmgA CDS" gene complement(2182275..2183456) /gene="mmgA" /locus_tag="BSU_24170" /old_locus_tag="BSU24170" /label="mmgA gene" downshifts complement(2183036) /Source="Nicolas_upshifts" /id="D1261" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="6.17207" /MaxDrop="2.33167" /score="-0.949614429" /energy="-7.8" /TU="U1884" /idTUdmin="U1885" /TUdmin=550 /isTUend="FALSE" /label="downshifts" misc_feature complement(2183143..2183149) /Source="Nicolas_upshift_promotors" /id="U1882" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.382617382617383" /psig="0.0869130869130869" /xcortree=1497 /SigmaFactorBS="tgaataaagtctgtgcttccggccttcgcgctgtcactttat gtgatcaaatgattcGGGCGCAggatgcggacatacttgttgcgggggggatggaaag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2183146) /Source="Nicolas_upshifts" /id="U1882" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.382617382617383" /psig="0.0869130869130869" /xcortree=1497 /SigmaFactorBS="tgaataaagtctgtgcttccggccttcgcgctgtcactttat gtgatcaaatgattcGGGCGCAggatgcggacatacttgttgcgggggggatggaaag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_no_box complement(2183370..2183470) /Source="Nicolas_upshift_promotors" /id="U1883" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.495504495504495" /psig="0.002997002997003" /xcortree=1483 /SigmaFactorBS="aatgaggtgaaaccatgaggaaaacagtcattgtaagtgctg caagaactccatttggcaaattcggcggagttttgaaagaggtgaaagctgctgagct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(2183410) /Source="Nicolas_upshifts" /id="U1883" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.495504495504495" /psig="0.002997002997003" /xcortree=1483 /SigmaFactorBS="aatgaggtgaaaccatgaggaaaacagtcattgtaagtgctg caagaactccatttggcaaattcggcggagttttgaaagaggtgaaagctgctgagct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2183503..2183521) /Source="Nicolas_upshift_promotors" /id="U1884" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1050 /SigmaFactorBS="tgttagaaggaggctgtttgacgcagccttcttttttcaTTC ATTcatgcccgtttcaaaGCATACATTCATAGAAGACaactagaaattgtaagcgctg t" /listShort="mmgA, mmgB, mmgC, prpC, prpD, prpB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2183521) /Source="Nicolas_upshifts" /id="U1884" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1050 /SigmaFactorBS="tgttagaaggaggctgtttgacgcagccttcttttttcaTTC ATTcatgcccgtttcaaaGCATACATTCATAGAAGACaactagaaattgtaagcgctg t" /listShort="mmgA, mmgB, mmgC, prpC, prpD, prpB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2183537..2183542) /Source="Nicolas_upshift_promotors" /id="U1884" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1050 /SigmaFactorBS="tgttagaaggaggctgtttgacgcagccttcttttttcaTTC ATTcatgcccgtttcaaaGCATACATTCATAGAAGACaactagaaattgtaagcgctg t" /listShort="mmgA, mmgB, mmgC, prpC, prpD, prpB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2183583..2184314) /gene="glpQ" /locus_tag="BSU_24180" /old_locus_tag="BSU24180" /EC_number="3.1.4.46" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6319195, 14563871, 21966272, 22843846, 24373430, 27780866" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6319195, 14563871, 21966272, 22843846, 24373430, 27780866; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="glycerophosphodiester phosphodiesterase (exolytic cleavage of individual teichoic acid monomer units)" /protein_id="NP_390298.2" /db_xref="EnsemblGenomes-Gn:BSU24180" /db_xref="EnsemblGenomes-Tr:CAB14349" /db_xref="GOA:P54527" /db_xref="InterPro:IPR004129" /db_xref="InterPro:IPR017946" /db_xref="InterPro:IPR030395" /db_xref="SubtiList:BG11719" /db_xref="UniProtKB/Swiss-Prot:P54527" /translation="MTKIFAHRGASGQFPENTMLAFEKGIEAGADGIELDVQLTKDGR IVVIHDERLNRTTSLKGFVKDTAYDEVKTANAAAGHDQAYSDIKVPLLEDVLSWAVKK DFLINIELKNSVIRYEGMEEKVLEAVKRFNVEDRVILSTFNHDSLALCARLAPHIERA VLTSDVLYQADRYIASIPASGYHPKINSPGVTDEVLKKMRNGLIKVRPYTVNRPEDMK RLIEAGADGMFTDFPEKASALLKNE*" /label="glpQ CDS" gene complement(2183583..2184314) /gene="glpQ" /locus_tag="BSU_24180" /old_locus_tag="BSU24180" /label="glpQ gene" downshifts complement(2183590) /Source="Nicolas_upshifts" /id="D1262" /incds=0 /nref=31 /ntot=180 /MaxReadThrough="0.31166" /MaxDrop="4.10202" /score="-0.949614429" /energy="-7.8" /TU="NA" /idTUdmin="U1885" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2184337..2184356) /Source="Nicolas_upshift_promotors" /id="U1885" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.838161838161838" /psig="0.999000999001" /xcortree=1960 /SigmaFactorBS="ttattatgatcagtagattgatacagccttaatcCTAGagtg gagccgacaaAATAAGTATAATGGAGAAAActttagggtttgaggtgaaacgatgaca a" /listShort="yqiK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2184348) /Source="Nicolas_upshifts" /id="U1885" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.838161838161838" /psig="0.999000999001" /xcortree=1960 /SigmaFactorBS="ttattatgatcagtagattgatacagccttaatcCTAGagtg gagccgacaaAATAAGTATAATGGAGAAAActttagggtttgaggtgaaacgatgaca a" /listShort="yqiK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2184371..2184374) /Source="Nicolas_upshift_promotors" /id="U1885" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.838161838161838" /psig="0.999000999001" /xcortree=1960 /SigmaFactorBS="ttattatgatcagtagattgatacagccttaatcCTAGagtg gagccgacaaAATAAGTATAATGGAGAAAActttagggtttgaggtgaaacgatgaca a" /listShort="yqiK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2184393..2185013) /gene="yqiI" /locus_tag="BSU_24190" /old_locus_tag="BSU24190" /EC_number="3.5.1.28" /experiment="publication(s) with functional evidences, PMID:22843846" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22843846; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylmuramoyl-L-alanine amidase" /protein_id="NP_390299.2" /db_xref="EnsemblGenomes-Gn:BSU24190" /db_xref="EnsemblGenomes-Tr:CAB14350" /db_xref="GOA:P54525" /db_xref="InterPro:IPR002508" /db_xref="SubtiList:BG11717" /db_xref="UniProtKB/Swiss-Prot:P54525" /translation="MRMLWRSLALCGLALTLAPCAQAAEPIEGKTVYIDAGHGGEDSG AVGNGLFEKDINLAVSEHVTDKLKEEGANPVASRSDDHFLTLEERVAKASANQADLFV SIHVNSGVASASGTETYFQSDYEGENSRRLASDIQSQLVSSLQTRDRGVKESDFYVIT YSQMPSVLAELGFITNSSDADKLGSEEYQQKAADAIVNGIDSYYDQ*" /label="yqiI CDS" gene complement(2184393..2185013) /gene="yqiI" /locus_tag="BSU_24190" /old_locus_tag="BSU24190" /label="yqiI gene" CDS complement(2185028..2185321) /gene="yqiH" /locus_tag="BSU_24200" /old_locus_tag="BSU24200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22843846; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_390300.2" /db_xref="EnsemblGenomes-Gn:BSU24200" /db_xref="EnsemblGenomes-Tr:CAB14351" /db_xref="GOA:P40770" /db_xref="SubtiList:BG11030" /db_xref="UniProtKB/Swiss-Prot:P40770" /translation="MKQTVLLLFTALFLSGCSVASADDSVPRFTEEGKYIGSADPHTI AVSLNGEETMIQVPKDKRDECESLPDQTHVLVKYTKKDNGTLQLEDIQLRKNS*" /label="yqiH CDS" gene complement(2185028..2185321) /gene="yqiH" /locus_tag="BSU_24200" /old_locus_tag="BSU24200" /label="yqiH gene" promotor_-10 complement(2185341..2185360) /Source="Nicolas_upshift_promotors" /id="U1886" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.909090909090909" /psig="0.978021978021978" /xcortree=2990 /SigmaFactorBS="aacttgctcgcctgcattcgcgttgTCTTTACAaattctcca ttctgGTCAAAGATAAAAGCCAAACatcaggaagaggtggtcatgtgaaacaaacggt t" /listShort="yqiH, yqiI, yqiK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2185347) /Source="Nicolas_upshifts" /id="U1886" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.909090909090909" /psig="0.978021978021978" /xcortree=2990 /SigmaFactorBS="aacttgctcgcctgcattcgcgttgTCTTTACAaattctcca ttctgGTCAAAGATAAAAGCCAAACatcaggaagaggtggtcatgtgaaacaaacggt t" /listShort="yqiH, yqiI, yqiK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2185375..2185382) /Source="Nicolas_upshift_promotors" /id="U1886" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.909090909090909" /psig="0.978021978021978" /xcortree=2990 /SigmaFactorBS="aacttgctcgcctgcattcgcgttgTCTTTACAaattctcca ttctgGTCAAAGATAAAAGCCAAACatcaggaagaggtggtcatgtgaaacaaacggt t" /listShort="yqiH, yqiI, yqiK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2185577..2185584 /Source="Nicolas_upshift_promotors" /id="U1887" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.973026973026973" /psig="0.996003996003996" /xcortree=1968 /SigmaFactorBS="tttgagaatagggtgagcaaatCGTTTGACgggtgggtcagc cAAGCGTAACCTTTTAAAGGAtatttactttattgaaagaagttaaagccatgaaaaa a" /listShort="S911, yqiG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2185598..2185617 /Source="Nicolas_upshift_promotors" /id="U1887" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.973026973026973" /psig="0.996003996003996" /xcortree=1968 /SigmaFactorBS="tttgagaatagggtgagcaaatCGTTTGACgggtgggtcagc cAAGCGTAACCTTTTAAAGGAtatttactttattgaaagaagttaaagccatgaaaaa a" /listShort="S911, yqiG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2185615..2185820 /Source="Nicolas_S_feature" /locus_tag="new_2516201_2516406" /HighExp="Diami, dia15, dia5, H2O2, Paraq, LBGexp, G180, LBGstat, LBGtran, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99653599999999998" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S911" upshifts 2185615 /Source="Nicolas_upshifts" /id="U1887" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.973026973026973" /psig="0.996003996003996" /xcortree=1968 /SigmaFactorBS="tttgagaatagggtgagcaaatCGTTTGACgggtgggtcagc cAAGCGTAACCTTTTAAAGGAtatttactttattgaaagaagttaaagccatgaaaaa a" /listShort="S911, yqiG" /GFF_Attribute="listLong" /label="upshifts" CDS 2185629..2185781 /locus_tag="BSU_24205" /old_locus_tag="BSU24205" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513977.1" /translation="MKEVKAMKKFVLLLAAAVITCSIGHQISGGYKGPEKERPKHHSA LKIFSR*" /label="hypothetical protein CDS" gene 2185629..2185781 /locus_tag="BSU_24205" /old_locus_tag="BSU24205" /label="gene" promotor_-35 2185789..2185796 /Source="Nicolas_upshift_promotors" /id="U1888" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.83016983016983" /psig="0.993006993006993" /xcortree=612 /SigmaFactorBS="tcaagatattcagtcggtaaagcagatCAATTGCAttaattt ttacataTAGGCTAGAATATGTGCGAAtccaaacgaaagaagatgatcaaatgaatcc t" /listShort="yqiG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2185811..2185830 /Source="Nicolas_upshift_promotors" /id="U1888" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.83016983016983" /psig="0.993006993006993" /xcortree=612 /SigmaFactorBS="tcaagatattcagtcggtaaagcagatCAATTGCAttaattt ttacataTAGGCTAGAATATGTGCGAAtccaaacgaaagaagatgatcaaatgaatcc t" /listShort="yqiG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2185822 /Source="Nicolas_upshifts" /id="U1888" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.83016983016983" /psig="0.993006993006993" /xcortree=612 /SigmaFactorBS="tcaagatattcagtcggtaaagcagatCAATTGCAttaattt ttacataTAGGCTAGAATATGTGCGAAtccaaacgaaagaagatgatcaaatgaatcc t" /listShort="yqiG" /GFF_Attribute="listLong" /label="upshifts" CDS 2185854..2186972 /gene="yqiG" /locus_tag="BSU_24210" /old_locus_tag="BSU24210" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NADH-dependent flavin oxidoreductase" /protein_id="NP_390301.1" /db_xref="EnsemblGenomes-Gn:BSU24210" /db_xref="EnsemblGenomes-Tr:CAB14352" /db_xref="GOA:P54524" /db_xref="InterPro:IPR001155" /db_xref="InterPro:IPR013785" /db_xref="SubtiList:BG11716" /db_xref="UniProtKB/Swiss-Prot:P54524" /translation="MNPKYKPLFEPFTFKSGVTINNRIAVAPMTHYASNEDGTISEAE LDYIIPRSKEMGMVITACANVTPDGKAFPGQPAIHDDSNIPGLKKLAQAIQAQGAKAV VQIHHGGIECPSELVPQQDVVGPSDVFDNGKQIARALTEEEVENIVKAFGEATRRAIE AGFDGVEIHGANGYLIQQFYSPKTNQRTDRWGGSDEKRLAFPLAIVDEVKKAASEHAK GAFLVGYRLSPEEPETPGLTMTETYTLVDALGDKELDYLHISLMDVNSKARRGADPTR TRMDLLNERVGNKVPLIAVGSIHSADDALAVIENGIPLVAMGREILVDPNWTVKVKEG REKQIETVIKGTDKEKYHLPEPLWQAIVNTQGWVPYKD*" /label="yqiG CDS" gene 2185854..2186972 /gene="yqiG" /locus_tag="BSU_24210" /old_locus_tag="BSU24210" /label="yqiG gene" downshifts 2186957 /Source="Nicolas_upshifts" /id="D1263" /incds=0 /nref=23 /ntot=181 /MaxReadThrough="1.88324" /MaxDrop="6.67511" /score="30.8551972" /energy="-16.1" /TU="NA" /idTUdmin="U1887" /TUdmin="-9" /isTUend="TRUE" /label="downshifts" S_feature complement(2186999..2187169) /Source="Nicolas_S_feature" /locus_tag="new_2517585_2517755_c" /HighExp="T0.30H, S6, S8, T1.30H, T1.0H, T-0.40H, S7, Salt, T0.0H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY, SigK" /TUshortPSig="1, 0.956" /TUlongSig="NA" /TUlongPSig="NA" /label="S912" downshifts complement(2187042) /Source="Nicolas_upshifts" /id="D1264" /incds=0 /nref=1 /ntot=37 /MaxReadThrough="3.46085" /MaxDrop="2.69939" /score="-5.47428449" /energy="-16.1" /TU="U1889" /idTUdmin="U1890" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2187153..2187168) /Source="Nicolas_upshift_promotors" /id="U1889" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1662 /SigmaFactorBS="tcacgaagcatgatcgaccctagatgtgtccgttataaaaTG AAACCTTTctcctgcaaaaTCGTAAGTAAGGCGTAttcatgtaaaaaggagacgtacg a" /listShort="S912" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2187169) /Source="Nicolas_upshifts" /id="U1889" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1662 /SigmaFactorBS="tcacgaagcatgatcgaccctagatgtgtccgttataaaaTG AAACCTTTctcctgcaaaaTCGTAAGTAAGGCGTAttcatgtaaaaaggagacgtacg a" /listShort="S912" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2187171..2187299) /Source="Nicolas_S_feature" /locus_tag="new_2517757_2517885_c" /HighExp="S6, S8, S7, S5, BT, M9-stat, B36, G180, G135, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.956" /TUlongSig="NA" /TUlongPSig="NA" /label="S913" promotor_-35 complement(2187180..2187189) /Source="Nicolas_upshift_promotors" /id="U1889" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1662 /SigmaFactorBS="tcacgaagcatgatcgaccctagatgtgtccgttataaaaTG AAACCTTTctcctgcaaaaTCGTAAGTAAGGCGTAttcatgtaaaaaggagacgtacg a" /listShort="S912" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2187298..2187317) /Source="Nicolas_upshift_promotors" /id="U1890" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1313 /SigmaFactorBS="ctgataaataggaggcgttttgttttggggacatttgtagta TGGGAGAAGaatattaagtatcCGCATATAGTAAAGGATAGGtttgaaaagtaaggaa a" /listShort="S913, S912" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2187321) /Source="Nicolas_upshifts" /id="U1890" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1313 /SigmaFactorBS="ctgataaataggaggcgttttgttttggggacatttgtagta TGGGAGAAGaatattaagtatcCGCATATAGTAAAGGATAGGtttgaaaagtaaggaa a" /listShort="S913, S912" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2187331..2187339) /Source="Nicolas_upshift_promotors" /id="U1890" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1313 /SigmaFactorBS="ctgataaataggaggcgttttgttttggggacatttgtagta TGGGAGAAGaatattaagtatcCGCATATAGTAAAGGATAGGtttgaaaagtaaggaa a" /listShort="S913, S912" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2187431) /Source="Nicolas_upshifts" /id="D1265" /incds=0 /nref=199 /ntot=267 /MaxReadThrough="2.54843" /MaxDrop="4.82417" /score="-1.10791055" /energy="-15.5" /TU="NA" /idTUdmin="U1891" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2187437..2188240) /gene="spo0A" /locus_tag="BSU_24220" /old_locus_tag="BSU24220" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8504245, 12406209, 15556029, 15808745, 23569226, 26152584, 27148245, 27501195, 28723971" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8504245, 12406209, 15556029, 15808745, 23569226, 26152584, 27148245, 27501195, 28723971; Product type r: regulator" /codon_start=1 /transl_table=11 /product="response regulator, phosphorylated in response to complex YlbF/YmcA/YaaT" /protein_id="NP_390302.1" /db_xref="EnsemblGenomes-Gn:BSU24220" /db_xref="EnsemblGenomes-Tr:CAB14353" /db_xref="GOA:P06534" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR012052" /db_xref="InterPro:IPR014879" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="PDB:1LQ1" /db_xref="SubtiList:BG10765" /db_xref="UniProtKB/Swiss-Prot:P06534" /translation="MEKIKVCVADDNRELVSLLSEYIEGQEDMEVIGVAYNGQECLSL FKEKDPDVLVLDIIMPHLDGLAVLERLRESDLKKQPNVIMLTAFGQEDVTKKAVDLGA SYFILKPFDMENLVGHIRQVSGNASSVTHRAPSSQSSIIRSSQPEPKKKNLDASITSI IHEIGVPAHIKGYLYLREAISMVYNDIELLGSITKVLYPDIAKKFNTTASRVERAIRH AIEVAWSRGNIDSISSLFGYTVSMTKAKPTNSEFIAMVADKLRLEHKAS*" /label="spo0A CDS" gene complement(2187437..2188240) /gene="spo0A" /locus_tag="BSU_24220" /old_locus_tag="BSU24220" /label="spo0A gene" promotor_-10 complement(2188283..2188301) /Source="Nicolas_upshift_promotors" /id="U1891" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=457 /SigmaFactorBS="ccactaatattggtgattatgatttttttAGAGGGTATatag cggtttTGTCGAATGTAAACATGTAgcaagggtgaatcctgttaactacatttgggga g" /listShort="spo0A" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2188289) /Source="Nicolas_upshifts" /id="U1891" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=457 /SigmaFactorBS="ccactaatattggtgattatgatttttttAGAGGGTATatag cggtttTGTCGAATGTAAACATGTAgcaagggtgaatcctgttaactacatttgggga g" /listShort="spo0A" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2188291..2188443) /Source="Nicolas_S_feature" /locus_tag="new_2518877_2519029_c" /HighExp="T1.30H, T3.0H, T2.30H, T2.0H, HiTm, Lbtran, T1.0H, T-0.40H, T0.30H, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S914" promotor_-35 complement(2188312..2188320) /Source="Nicolas_upshift_promotors" /id="U1891" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=457 /SigmaFactorBS="ccactaatattggtgattatgatttttttAGAGGGTATatag cggtttTGTCGAATGTAAACATGTAgcaagggtgaatcctgttaactacatttgggga g" /listShort="spo0A" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2188439..2188458) /Source="Nicolas_upshift_promotors" /id="U1892" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=2278 /SigmaFactorBS="cggagtttccggcagtttttttattttgatccctCTTCACTT ctcagaatacaTACGGTAAAATATACAAAAGaagatttttcgacaaattcacgtttcc t" /listShort="S914, spo0A" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2188451) /Source="Nicolas_upshifts" /id="U1892" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=2278 /SigmaFactorBS="cggagtttccggcagtttttttattttgatccctCTTCACTT ctcagaatacaTACGGTAAAATATACAAAAGaagatttttcgacaaattcacgtttcc t" /listShort="S914, spo0A" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2188470..2188477) /Source="Nicolas_upshift_promotors" /id="U1892" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=2278 /SigmaFactorBS="cggagtttccggcagtttttttattttgatccctCTTCACTT ctcagaatacaTACGGTAAAATATACAAAAGaagatttttcgacaaattcacgtttcc t" /listShort="S914, spo0A" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2188516..2189796) /gene="spoIVB" /locus_tag="BSU_24230" /old_locus_tag="BSU24230" /EC_number="3.4.-.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12218026, 15292188, 16164552, 16238631, 16818230, 17493131, 17557826" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12218026, 15292188, 16164552, 16238631, 16818230, 17493131, 17557826; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="regulatory membrane-associated serine protease" /protein_id="NP_390303.2" /db_xref="EnsemblGenomes-Gn:BSU24230" /db_xref="EnsemblGenomes-Tr:CAB14354" /db_xref="GOA:P17896" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR008763" /db_xref="InterPro:IPR009003" /db_xref="InterPro:IPR014219" /db_xref="InterPro:IPR036034" /db_xref="SubtiList:BG10311" /db_xref="UniProtKB/Swiss-Prot:P17896" /translation="MPDNIRKAVGLILLVSLLSVGLCKPLKEYLLIPTQMRVFETQTQ AIETSLSVNAQTSESSEAFTVKKDPHEIKVTGKKSGESELVYDLAGFPIKKTKVHVLP DLKVIPGGQSIGVKLHSVGVLVVGFHQINTSEGKKSPGETAGIEAGDIIIEMNGQKIE KMNDVAPFIQKAGKTGESLDLLIKRDKQKIKTKLIPEKDEGEGKYRIGLYIRDSAAGI GTMTFYEPKTKKYGALGHVISDMDTKKPIVVENGEIVKSTVTSIEKGTGGNPGEKLAR FSSERKTIGDINRNSPFGIFGTLHQPIQNNISDQALPVAFSTEVKKGPAEILTVIDDD KVEKFDIEIVSTTPQKFPATKGMVLKITDPRLLKETGGIVQGMSGSPIIQNGKVIGAV THVFVNDPTSGYGVHIEWMLSEAGIDIYGKEKAS*" /label="spoIVB CDS" gene complement(2188516..2189796) /gene="spoIVB" /locus_tag="BSU_24230" /old_locus_tag="BSU24230" /label="spoIVB gene" downshifts complement(2188531) /Source="Nicolas_upshifts" /id="D1266" /incds=0 /nref=34 /ntot=51 /MaxReadThrough="1.04939" /MaxDrop="7.80695" /score="49.1812184" /energy="-12.5" /TU="NA" /idTUdmin="U1893" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2189857..2189868) /Source="Nicolas_upshift_promotors" /id="U1893" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=830 /SigmaFactorBS="cattcgttcatcagtatatccaatgtttttcttcatatgaca GTTATAAataagccgtcagaaGGCAAAATTAAAtgatgtagcagcaagtcataaagaa g" /listShort="spoIVB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2189871) /Source="Nicolas_upshifts" /id="U1893" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=830 /SigmaFactorBS="cattcgttcatcagtatatccaatgtttttcttcatatgaca GTTATAAataagccgtcagaaGGCAAAATTAAAtgatgtagcagcaagtcataaagaa g" /listShort="spoIVB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2189883..2189889) /Source="Nicolas_upshift_promotors" /id="U1893" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=830 /SigmaFactorBS="cattcgttcatcagtatatccaatgtttttcttcatatgaca GTTATAAataagccgtcagaaGGCAAAATTAAAtgatgtagcagcaagtcataaagaa g" /listShort="spoIVB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2189971..2191701) /gene="recN" /locus_tag="BSU_24240" /old_locus_tag="BSU24240" /function="16.8: Protect" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:15186413, 15849320, 15948952, 16009134, 16061691, 16385024, 17999999, 20360008, 21517913, 23380520, 24373815" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15186413, 15849320, 15948952, 16009134, 16061691, 16385024, 17999999, 20360008, 21517913, 23380520, 24373815; Product type f : factor" /codon_start=1 /transl_table=11 /product="factor for double strand breaks DNA repair and genetic recombination" /protein_id="NP_390304.2" /db_xref="EnsemblGenomes-Gn:BSU24240" /db_xref="EnsemblGenomes-Tr:CAB14355" /db_xref="GOA:P17894" /db_xref="InterPro:IPR004604" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10310" /db_xref="UniProtKB/Swiss-Prot:P17894" /translation="MLAELSIKNFAIIEELTVSFERGLTVLTGETGAGKSIIIDAISL LVGGRGSSEFVRYGEAKAELEGLFLLESGHPVLGVCAEQGIDVSDEMIVMRRDISTSG KSVCRVNGKLVTIASLREIGRLLLDIHGQHDNQLLMEDENHLQLLDKFAGAEVESALK TYQEGYQRYVKLLKKLKQLSESEQEMAHRLDLIQFQLEEIESAKLELNEDEQLQEERQ QISNFEKIYESLQNAYNALRSEQGGLDWVGMASAQLEDISDINEPLKKMSESVSNSYY LLEDATFQMRNMLDELEFDPERLNYIETRLNEIKQLKRKYGATVEDILEYASKIEEEI DQIENRDSHLQSLKKELDSVGKDVAVEAANVSQIRKTWAKKLADEIHRELKSLYMEKS TFDTEFKVRTASRNEEAPLVNGQPVQLTEQGIDLVKFLISTNTGEPLKSLSKVASGGE LSRVMLAIKSIFSSQQDVTSIIFDEVDTGVSGRVAQAIAEKIHKVSIGSQVLCITHLP QVAAMADTHLYIAKELKDGRTTTRVKPLSKQEKVAEIGRMIAGVEVTDLTKRHAKELL KQADQVKTTG*" /label="recN CDS" gene complement(2189971..2191701) /gene="recN" /locus_tag="BSU_24240" /old_locus_tag="BSU24240" /label="recN gene" downshifts complement(2189986) /Source="Nicolas_upshifts" /id="D1267" /incds=0 /nref=232 /ntot=260 /MaxReadThrough="1.73202" /MaxDrop="6.33427" /score="20.028822" /energy="-12.4" /TU="NA" /idTUdmin="U1895" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2191738..2192187) /gene="argR" /locus_tag="BSU_24250" /old_locus_tag="BSU24250" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:180070, 9194709, 9383188, 11305941, 11856827, 17020585, 17576690, 18007040, 18455186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 180070, 9194709, 9383188, 11305941, 11856827, 17020585, 17576690, 18007040, 18455186; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (AhrC(ArgR)-arginine)" /protein_id="NP_390305.1" /db_xref="EnsemblGenomes-Gn:BSU24250" /db_xref="EnsemblGenomes-Tr:CAB14356" /db_xref="GOA:P17893" /db_xref="InterPro:IPR001669" /db_xref="InterPro:IPR020899" /db_xref="InterPro:IPR020900" /db_xref="InterPro:IPR024946" /db_xref="InterPro:IPR036251" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:1F9N" /db_xref="PDB:2P5K" /db_xref="PDB:2P5L" /db_xref="PDB:2P5M" /db_xref="SubtiList:BG10309" /db_xref="UniProtKB/Swiss-Prot:P17893" /translation="MNKGQRHIKIREIITSNEIETQDELVDMLKQDGYKVTQATVSRD IKELHLVKVPTNNGSYKYSLPADQRFNPLSKLKRALMDAFVKIDSASHMIVLKTMPGN AQAIGALMDNLDWDEMMGTICGDDTILIICRTPEDTEGVKNRLLELL*" /label="argR CDS" gene complement(2191738..2192187) /gene="argR" /locus_tag="BSU_24250" /old_locus_tag="BSU24250" /label="argR gene" S_feature complement(2192188..2192273) /Source="Nicolas_S_feature" /locus_tag="new_2522774_2522859_c" /HighExp="H2O2, G180, G135, G150, Oxctl, Heat, Paraq, C30, dia15, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.999, 0.993, 1" /TUlongSig="SigB" /TUlongPSig="0.742" /label="S915" CDS complement(2192285..2193130) /gene="yqxC" /locus_tag="BSU_24260" /old_locus_tag="BSU24260" /EC_number="2.1.1.-" /function="9.4: RNA processing" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16014871, 22333191, 24809820; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 2'-O-ribose RNA methyltransferase" /protein_id="NP_390306.2" /db_xref="EnsemblGenomes-Gn:BSU24260" /db_xref="EnsemblGenomes-Tr:CAB14357" /db_xref="GOA:P19672" /db_xref="InterPro:IPR002877" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR004538" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG10308" /db_xref="UniProtKB/Swiss-Prot:P19672" /translation="MTSKKERLDVLLVERGLAETREKAKRAIMAGIVYSNENRLDKPG EKIDRDLPLTVKGNPLRYVSRGGLKLEKALKEFPVSVKDKIMIDIGSSTGGFTDCALQ NGAKQSYAVDVGYNQLAWKLRQDERVVVMERTNFRYATPADFTKGMPEFATIDVSFIS LRLILPVLRTLLVPGSDCMALVKPQFEAGRESVGKKGIVRDPKVHADVLKRMISFSAA EGYICKGLSFSPITGGDGNIEFLLHLHWPGEGQEGQELPEEEIMRVVEEAHKTLKEKK ADVPE*" /label="yqxC CDS" gene complement(2192285..2193130) /gene="yqxC" /locus_tag="BSU_24260" /old_locus_tag="BSU24260" /label="yqxC gene" downshifts complement(2192318) /Source="Nicolas_upshifts" /id="D1268" /incds=0 /nref=1 /ntot=65 /MaxReadThrough="5.65358" /MaxDrop="2.6955" /score="4.97422627" /energy="-9.4" /TU="U1895,U1896,U1898" /idTUdmin="U1895" /TUdmin="-2332" /isTUend="FALSE" /label="downshifts" CDS complement(2193127..2195028) /gene="dxs" /locus_tag="BSU_24270" /old_locus_tag="BSU24270" /EC_number="2.2.1.7" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 12882400, 15292217, 17458547, 23840410, 25212876; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="1-deoxyxylulose-5-phosphate synthase" /protein_id="NP_390307.1" /db_xref="EnsemblGenomes-Gn:BSU24270" /db_xref="EnsemblGenomes-Tr:CAB14358" /db_xref="GOA:P54523" /db_xref="InterPro:IPR005474" /db_xref="InterPro:IPR005475" /db_xref="InterPro:IPR005477" /db_xref="InterPro:IPR009014" /db_xref="InterPro:IPR020826" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR033248" /db_xref="SubtiList:BG11715" /db_xref="UniProtKB/Swiss-Prot:P54523" /translation="MDLLSIQDPSFLKNMSIDELEKLSDEIRQFLITSLSASGGHIGP NLGVVELTVALHKEFNSPKDKFLWDVGHQSYVHKLLTGRGKEFATLRQYKGLCGFPKR SESEHDVWETGHSSTSLSGAMGMAAARDIKGTDEYIIPIIGDGALTGGMALEALNHIG DEKKDMIVILNDNEMSIAPNVGAIHSMLGRLRTAGKYQWVKDELEYLFKKIPAVGGKL AATAERVKDSLKYMLVSGMFFEELGFTYLGPVDGHSYHELIENLQYAKKTKGPVLLHV ITKKGKGYKPAETDTIGTWHGTGPYKINTGDFVKPKAAAPSWSGLVSGTVQRMAREDG RIVAITPAMPVGSKLEGFAKEFPDRMFDVGIAEQHAATMAAAMAMQGMKPFLAIYSTF LQRAYDQVVHDICRQNANVFIGIDRAGLVGADGETHQGVFDIAFMRHIPNMVLMMPKD ENEGQHMVHTALSYDEGPIAMRFPRGNGLGVKMDEQLKTIPIGTWEVLRPGNDAVILT FGTTIEMAIEAAEELQKEGLSVRVVNARFIKPIDEKMMKSILKEGLPILTIEEAVLEG GFGSSILEFAHDQGEYHTPIDRMGIPDRFIEHGSVTALLEEIGLTKQQVANRIRLLMP PKTHKGIGS*" /label="dxs CDS" gene complement(2193127..2195028) /gene="dxs" /locus_tag="BSU_24270" /old_locus_tag="BSU24270" /label="dxs gene" promotor_-35 2194236..2194242 /Source="Nicolas_upshift_promotors" /id="U1894" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=952 /SigmaFactorBS="tgcagaagaacagggcctttcgtttttttggCGTATTGaaga ttctcaatcaGCTCATGATAAGaatgtccgtccactgggcccaaatacgtaaaaccga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2194257..2194268 /Source="Nicolas_upshift_promotors" /id="U1894" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=952 /SigmaFactorBS="tgcagaagaacagggcctttcgtttttttggCGTATTGaaga ttctcaatcaGCTCATGATAAGaatgtccgtccactgggcccaaatacgtaaaaccga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2194265 /Source="Nicolas_upshifts" /id="U1894" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=952 /SigmaFactorBS="tgcagaagaacagggcctttcgtttttttggCGTATTGaaga ttctcaatcaGCTCATGATAAGaatgtccgtccactgggcccaaatacgtaaaaccga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2195029..2195157) /Source="Nicolas_S_feature" /locus_tag="new_2525615_2525743_c" /HighExp="Salt, Heat, dia15, H2O2, HiOs, Cold, T-5.40H, T3.30H, SMM, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.999, 0.993, 1" /TUlongSig="SigB" /TUlongPSig="0.742" /label="S916" promotor_-10 complement(2195152..2195171) /Source="Nicolas_upshift_promotors" /id="U1895" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.508491508491508" /psig="0.999000999001" /xcortree=2286 /SigmaFactorBS="gcaagagatcactaaaacgatcctaATTTGAAgcggctgcac gaggTATGGTAAAATGTAAGCAGTttatatgaaaaatgaaaaggaaaagcgcgtttgt c" /listShort="S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2195157) /Source="Nicolas_upshifts" /id="U1895" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.508491508491508" /psig="0.999000999001" /xcortree=2286 /SigmaFactorBS="gcaagagatcactaaaacgatcctaATTTGAAgcggctgcac gaggTATGGTAAAATGTAAGCAGTttatatgaaaaatgaaaaggaaaagcgcgtttgt c" /listShort="S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2195186..2195192) /Source="Nicolas_upshift_promotors" /id="U1895" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.508491508491508" /psig="0.999000999001" /xcortree=2286 /SigmaFactorBS="gcaagagatcactaaaacgatcctaATTTGAAgcggctgcac gaggTATGGTAAAATGTAAGCAGTttatatgaaaaatgaaaaggaaaagcgcgtttgt c" /listShort="S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2195203..2196093) /gene="ispA" /locus_tag="BSU_24280" /old_locus_tag="BSU24280" /EC_number="2.5.1.10" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8755734, 12682299, 17147392, 23569278; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="farnesyl diphosphate synthase" /protein_id="NP_390308.2" /db_xref="EnsemblGenomes-Gn:BSU24280" /db_xref="EnsemblGenomes-Tr:CAB14359" /db_xref="GOA:P54383" /db_xref="InterPro:IPR000092" /db_xref="InterPro:IPR008949" /db_xref="InterPro:IPR033749" /db_xref="SubtiList:BG11714" /db_xref="UniProtKB/Swiss-Prot:P54383" /translation="MTNKLTSFLADRKKTIENQLSVYTEKLDMPDSLKKSMLYSLQAG GKRLRPLIVLAVLNAYGKSEKDGIPVGCAVEMIHTYSLIHDDLPCMDDDDLRRGKPTN HKVFGEATAVLAGDGLLTESFKLITSHVSDEVSAEKRLRLVNELISAAGTEGMVGGQV ADMEAENRQVTLEELESIHERKTAKLLGFCVIAGAILADAPEEDIETLRTFSSHIGIG FQIRDDILDLEGSEEKIGKRVGSDTTNDKSTYPSLLSLEGAKHKLDVHIKEAKRLIGG LSLQKDLLYELCDLIAARDH*" /label="ispA CDS" gene complement(2195203..2196093) /gene="ispA" /locus_tag="BSU_24280" /old_locus_tag="BSU24280" /label="ispA gene" CDS complement(2196083..2196337) /gene="xseB" /locus_tag="BSU_24290" /old_locus_tag="BSU24290" /EC_number="3.1.11.6" /function="16.6: Maintain" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11381137, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exodeoxyribonuclease VII (small subunit)" /protein_id="NP_390309.2" /db_xref="EnsemblGenomes-Gn:BSU24290" /db_xref="EnsemblGenomes-Tr:CAB14360" /db_xref="GOA:P54522" /db_xref="InterPro:IPR003761" /db_xref="InterPro:IPR037004" /db_xref="SubtiList:BG11713" /db_xref="UniProtKB/Swiss-Prot:P54522" /translation="MTDVKKNENMTFEEAMKGLESIVSKLEEGDVPLEQAINYFQEGM ALSKMCHEKLQKVEKQMDFILKEDGELAPFSVQEEDEGDK*" /label="xseB CDS" gene complement(2196083..2196337) /gene="xseB" /locus_tag="BSU_24290" /old_locus_tag="BSU24290" /label="xseB gene" CDS complement(2196334..2197680) /gene="xseA" /locus_tag="BSU_24300" /old_locus_tag="BSU24300" /EC_number="3.1.11.6" /function="16.9: Replicate" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 17182742; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exodeoxyribonuclease VII (large subunit)" /protein_id="NP_390310.2" /db_xref="EnsemblGenomes-Gn:BSU24300" /db_xref="EnsemblGenomes-Tr:CAB14361" /db_xref="GOA:P54521" /db_xref="InterPro:IPR003753" /db_xref="InterPro:IPR020579" /db_xref="InterPro:IPR025824" /db_xref="SubtiList:BG11712" /db_xref="UniProtKB/Swiss-Prot:P54521" /translation="MGEAAYVTVSALTKYIKRKFDVDPHLENIWIKGELSNVKIHTRG HIYFTLKDENARMQSVMFARQSERLPFKPENGMKVLVRGGISVYEPSGNYQLYAKEMQ PDGVGALYLAYEELKKKLAGEGLFDDRYKKQIPAFPATIGVVTSPTGAAVRDVITTLK RRYPLVKVIVLPALVQGENASRSIVTRIEEANEKEICDVLIVGRGGGSIEELWAFNEE IVARAIFASNIPIISAVGHETDFTISDFVADIRAATPTGAAEIAVPHTTDLIERTKTA EVRMTRAMQQHLGQKKERIQTLQSSYAFRFPKRLYAQKEQQFDLAYQQFQAQLTALLD RKSRQLERETYRLEALHPHEQLKQARTRYQEQTNQLRKNMNIQMKQLHSQFQTVLGKL NALSPLQVMERGYSLAYKEDKLIKSVSQIEEQDRLEIKLKDGVLTCEVLEKRGEEK*" /label="xseA CDS" gene complement(2196334..2197680) /gene="xseA" /locus_tag="BSU_24300" /old_locus_tag="BSU24300" /label="xseA gene" S_feature complement(2197681..2197817) /Source="Nicolas_S_feature" /locus_tag="new_2528267_2528403_c" /HighExp="H2O2, G180, G135, Cold, G150, Paraq, Oxctl, LBGstat, LPh, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB, SigA" /TUshortPSig="0.993, 0.742, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S917" CDS complement(2197818..2198669) /gene="folD" /locus_tag="BSU_24310" /old_locus_tag="BSU24310" /EC_number="1.5.1.5" /EC_number="3.5.4.9" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7061514, 9454603, 12682299, 19171795; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylenetetrahydrofolate dehydrogenase; methenyltetrahydrofolate cyclohydrolase" /protein_id="NP_390311.1" /db_xref="EnsemblGenomes-Gn:BSU24310" /db_xref="EnsemblGenomes-Tr:CAB14362" /db_xref="GOA:P54382" /db_xref="InterPro:IPR000672" /db_xref="InterPro:IPR020630" /db_xref="InterPro:IPR020631" /db_xref="InterPro:IPR020867" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11711" /db_xref="UniProtKB/Swiss-Prot:P54382" /translation="MTATIIDGKETAREKREQLAKEVEELKKQGVTPGLAVILIGDDP ASHSYVRGKKKAAETMGMNFKLDQFDSSLTEAELLSIIDQYNQDPEFHGILVQLPLPD HISEKAVIERISPDKDVDGFHPLNVGKMLLGEDTFLPCTPHGIVELLKKTNIDLSGKE VVVVGRSNIVGKPVGQLLLNENATVTYCHSRTENITEHTKKADILVVAVGRANFISAD QIKEGAVVIDVGVNRLENGKLCGDVEFEGAKEKASFITPVPGGVGPMTITMLAHNTVK SAKRTLS*" /label="folD CDS" gene complement(2197818..2198669) /gene="folD" /locus_tag="BSU_24310" /old_locus_tag="BSU24310" /label="folD gene" CDS complement(2198681..2199076) /gene="nusB" /locus_tag="BSU_24320" /old_locus_tag="BSU24320" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16707701, 16946247, 27964882; Product type f: factor" /codon_start=1 /transl_table=11 /product="transcription termination factor NusB" /protein_id="NP_390312.2" /db_xref="EnsemblGenomes-Gn:BSU24320" /db_xref="EnsemblGenomes-Tr:CAB14363" /db_xref="GOA:P54520" /db_xref="InterPro:IPR006027" /db_xref="InterPro:IPR011605" /db_xref="InterPro:IPR035926" /db_xref="SubtiList:BG11710" /db_xref="UniProtKB/Swiss-Prot:P54520" /translation="MKRRTAREKALQALFQIDVSDIAVNEAIEHALDEEKTDPFFEQL VHGVLEHQDQLDEMISKHLVNWKLDRIANVDRAILRLAAYEMAYAEDIPVNVSMNEAI ELAKRFGDDKATKFVNGVLSNIKSDIEQS*" /label="nusB CDS" gene complement(2198681..2199076) /gene="nusB" /locus_tag="BSU_24320" /old_locus_tag="BSU24320" /label="nusB gene" misc_feature complement(2199119..2199138) /Source="Nicolas_upshift_promotors" /id="U1896" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.416583416583417" /psig="0.993006993006993" /xcortree=2425 /SigmaFactorBS="tgaaaatattcggtaatagggtaaaaaaaccttgatttcaat atgcggatacgaaaaaaaTATGTTATGATCTCTTTGTGgcttaacgacaagcggataa a" /listShort="nusB, folD, S917, xseA, xseB, ispA, S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2199138) /Source="Nicolas_upshifts" /id="U1896" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.416583416583417" /psig="0.993006993006993" /xcortree=2425 /SigmaFactorBS="tgaaaatattcggtaatagggtaaaaaaaccttgatttcaat atgcggatacgaaaaaaaTATGTTATGATCTCTTTGTGgcttaacgacaagcggataa a" /listShort="nusB, folD, S917, xseA, xseB, ispA, S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2199140..2199302) /Source="Nicolas_S_feature" /locus_tag="new_2529726_2529888_c" /HighExp="G180, G150, Oxctl, Etha, G135, GM 120, dia0, HPh, MG 150, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="0.742, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S918" CDS complement(2199340..2199747) /gene="yqhY" /locus_tag="BSU_24330" /old_locus_tag="BSU24330" /function="16.13: Shape" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16014871, 17114254, 22720735, 28579978" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16014871, 17114254, 22720735, 28579978; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="alkaline shock protein" /protein_id="NP_390313.2" /db_xref="EnsemblGenomes-Gn:BSU24330" /db_xref="EnsemblGenomes-Tr:CAB14364" /db_xref="InterPro:IPR005531" /db_xref="SubtiList:BG11709" /db_xref="UniProtKB/Swiss-Prot:P54519" /translation="MKDNSLLKMDHEDTHLGKVEIAPEVIEVIAGIAASEVDGVAEMR GNFATGVVERFGKVNHGKGVKVDLADDGITIDVYCVVTFGVSIPKVAASVQENIRQTL LNMTSLSINEINIHIVGIQFDTKAQEVQIDEEM*" /label="yqhY CDS" gene complement(2199340..2199747) /gene="yqhY" /locus_tag="BSU_24330" /old_locus_tag="BSU24330" /label="yqhY gene" downshifts complement(2199347) /Source="Nicolas_upshifts" /id="D1269" /incds=0 /nref=6 /ntot=76 /MaxReadThrough="6.4099" /MaxDrop="4.1473" /score="9.44795832" /energy="-9.5" /TU="U1897,U1898" /idTUdmin="U1899" /TUdmin=2409 /isTUend="FALSE" /label="downshifts" CDS complement(2199768..2201120) /gene="accC" /locus_tag="BSU_24340" /old_locus_tag="BSU24340" /EC_number="6.3.4.14" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7592499, 12682299, 14594796" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7592499, 12682299, 14594796; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-CoA carboxylase subunit (biotin carboxylase subunit)" /protein_id="NP_390314.2" /db_xref="EnsemblGenomes-Gn:BSU24340" /db_xref="EnsemblGenomes-Tr:CAB14365" /db_xref="GOA:P49787" /db_xref="InterPro:IPR004549" /db_xref="InterPro:IPR005479" /db_xref="InterPro:IPR005481" /db_xref="InterPro:IPR005482" /db_xref="InterPro:IPR011054" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR011764" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="SubtiList:BG11384" /db_xref="UniProtKB/Swiss-Prot:P49787" /translation="MIKKLLIANRGEIAVRIIRACRELGIETVAVYSEADKDALHVQM ADEAFCIGPKASKDSYLNVTNIVSVAKLTGTDAIHPGYGFLAENADFAELCEEVNVTF VGPSADAISKMGTKDVARETMKQAGVPIVPGSQGIIENVEEAVSLANEIGYPVIIKAT AGGGGKGIRVARTEEELINGIKITQQEAATAFGNPGVYIEKYIEDFRHVEIQVLADNY GNTIHLGERDCSIQRRLQKLLEESPSPALDSEIREQMGDAAVKAAKAVGYTGAGTVEF IYDYNEQRYYFMEMNTRIQVEHPVTEMVTGTDLIKEQIKVASGMELSLKQEDVEFEGW AIECRINAENPSKNFMPSPGEIKMYLPPGGLGVRVDSAAYPGYSIPPYYDSMIAKVIT YGKTRDEAIARMKRALSEFVIEGIETTIPFHLKLLEHETFVSGEFNTKFLETYDVMGS *" /label="accC CDS" gene complement(2199768..2201120) /gene="accC" /locus_tag="BSU_24340" /old_locus_tag="BSU24340" /label="accC gene" promotor_-10 complement(2200649..2200668) /Source="Nicolas_upshift_promotors" /id="U1897" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.742257742257742" /psig="0.742257742257742" /xcortree=127 /SigmaFactorBS="gggaattatagaaaatgtggaagaagcGGTTTCGcttgctaa tgaaatTGGGTATCCTGTAATTATAAaagccaccgcaggcggaggcggaaaaggaatt a" /listShort="yqhY, S918, nusB, folD, S917, xseA, xseB, ispA" /listLong="S916, dxs, yqxC, S915, ahrC, recN" /label="promotor_-10" upshifts complement(2200656) /Source="Nicolas_upshifts" /id="U1897" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.742257742257742" /psig="0.742257742257742" /xcortree=127 /SigmaFactorBS="gggaattatagaaaatgtggaagaagcGGTTTCGcttgctaa tgaaatTGGGTATCCTGTAATTATAAaagccaccgcaggcggaggcggaaaaggaatt a" /listShort="yqhY, S918, nusB, folD, S917, xseA, xseB, ispA" /listLong="S916, dxs, yqxC, S915, ahrC, recN" /label="upshifts" promotor_-35 complement(2200683..2200689) /Source="Nicolas_upshift_promotors" /id="U1897" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.742257742257742" /psig="0.742257742257742" /xcortree=127 /SigmaFactorBS="gggaattatagaaaatgtggaagaagcGGTTTCGcttgctaa tgaaatTGGGTATCCTGTAATTATAAaagccaccgcaggcggaggcggaaaaggaatt a" /listShort="yqhY, S918, nusB, folD, S917, xseA, xseB, ispA" /listLong="S916, dxs, yqxC, S915, ahrC, recN" /label="promotor_-35" CDS complement(2201132..2201611) /gene="accB" /locus_tag="BSU_24350" /old_locus_tag="BSU24350" /EC_number="6.4.1.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7592499, 12682299, 14594796, 15518551" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7592499, 12682299, 14594796, 15518551; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-CoA carboxylase subunit (biotin carboxyl carrier subunit)" /protein_id="NP_390315.1" /db_xref="EnsemblGenomes-Gn:BSU24350" /db_xref="EnsemblGenomes-Tr:CAB14366" /db_xref="GOA:P49786" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR001249" /db_xref="InterPro:IPR001882" /db_xref="InterPro:IPR011053" /db_xref="SubtiList:BG11383" /db_xref="UniProtKB/Swiss-Prot:P49786" /translation="MLNIKEIHELIKAIDESTIDEFVYENEGVSLKLKKHEAGTVQVM QQAPAAPVQAQAPQAVQPQAQQAAAPAQEAPKQDENLHKITSPMVGTFYASSSPEAGP YVTAGSKVNENTVVCIVEAMKLFNEIEAEVKGEIVEVLVENGQLVEYGQPLFLVKAE* " /label="accB CDS" gene complement(2201132..2201611) /gene="accB" /locus_tag="BSU_24350" /old_locus_tag="BSU24350" /label="accB gene" promotor_-10 complement(2201670..2201689) /Source="Nicolas_upshift_promotors" /id="U1898" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.727272727272727" /psig=1 /xcortree=2334 /SigmaFactorBS="caagcgggctttttgcgttgctgtcatattaGAGTTGAAttc aaaagtccgcTCCTGTAAGATGAACATAGTatgtacttttagtagtaacctataaaaa a" /listShort="accB, accC, yqhY, S918, nusB, folD, S917, xseA, xseB, ispA, S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2201681) /Source="Nicolas_upshifts" /id="U1898" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.727272727272727" /psig=1 /xcortree=2334 /SigmaFactorBS="caagcgggctttttgcgttgctgtcatattaGAGTTGAAttc aaaagtccgcTCCTGTAAGATGAACATAGTatgtacttttagtagtaacctataaaaa a" /listShort="accB, accC, yqhY, S918, nusB, folD, S917, xseA, xseB, ispA, S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2201703..2201710) /Source="Nicolas_upshift_promotors" /id="U1898" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.727272727272727" /psig=1 /xcortree=2334 /SigmaFactorBS="caagcgggctttttgcgttgctgtcatattaGAGTTGAAttc aaaagtccgcTCCTGTAAGATGAACATAGTatgtacttttagtagtaacctataaaaa a" /listShort="accB, accC, yqhY, S918, nusB, folD, S917, xseA, xseB, ispA, S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2201767..2202423) /gene="spoIIIAH" /locus_tag="BSU_24360" /old_locus_tag="BSU24360" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15028710, 15752199, 16959571, 1766372" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15028710, 15752199, 16959571, 1766372; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage III sporulation ratchet engulfment protein" /protein_id="NP_390316.2" /db_xref="EnsemblGenomes-Gn:BSU24360" /db_xref="EnsemblGenomes-Tr:CAB14367" /db_xref="GOA:P49785" /db_xref="InterPro:IPR024232" /db_xref="PDB:3TUF" /db_xref="PDB:3UZ0" /db_xref="SubtiList:BG11415" /db_xref="UniProtKB/Swiss-Prot:P49785" /translation="MLKKQTVWLLTMLSLVVVLSVYYIMSPESKNAVQMQSEKSASDS GEVATEKAPAKQDTKEKSGTETEKGKEDGTKGTKDSSADKETSAEASEKGTVVTETAD DDLFTTYRLDLEDARSKEREELNAIVSSDDATAKEKSEAYDKMTALSEVEGTEKQLET LIKTQGYEDALVNAEGDKINITVKSDKHSKSKATAIIDLVAKEIKTMKDVAVTFEPSK *" /label="spoIIIAH CDS" gene complement(2201767..2202423) /gene="spoIIIAH" /locus_tag="BSU_24360" /old_locus_tag="BSU24360" /label="spoIIIAH gene" downshifts complement(2201774) /Source="Nicolas_upshifts" /id="D1270" /incds=0 /nref=26 /ntot=57 /MaxReadThrough="0.0903599999999987" /MaxDrop="6.40434" /score="21.0450747" /energy="-13" /TU="NA" /idTUdmin="U1899" /TUdmin="-18" /isTUend="TRUE" /label="downshifts" CDS complement(2202424..2203113) /gene="spoIIIAG" /locus_tag="BSU_24370" /old_locus_tag="BSU24370" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1766372, 15028710, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766372, 15028710, 28784753; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage III sporulation engulfment assembly protein" /protein_id="NP_390317.2" /db_xref="EnsemblGenomes-Gn:BSU24370" /db_xref="EnsemblGenomes-Tr:CAB14368" /db_xref="GOA:P49784" /db_xref="InterPro:IPR014195" /db_xref="SubtiList:BG11414" /db_xref="UniProtKB/Swiss-Prot:P49784" /translation="MNKNGLWNVLKKQFLPGQTKDGEKPKLTKYHYFLFVFVLGVSFM LVSQLFSSPEKTENAKTITAVSSQHSADSKEKTAEVFKASKSDKPKDSIDDYEKEYEN QLKEILETIIGVDDVSVVVNVDATSLKVYEKNKSNKNTTTEETDKEGGKRSVTDQSSE EEIVMIKNGDKETPVVVQTKKPDIRGVLVVAQGVDNVQIKQTIIEAVTRVLDVPSHRV AVAPKKIKEDS*" /label="spoIIIAG CDS" gene complement(2202424..2203113) /gene="spoIIIAG" /locus_tag="BSU_24370" /old_locus_tag="BSU24370" /label="spoIIIAG gene" CDS complement(2203106..2203726) /gene="spoIIIAF" /locus_tag="BSU_24380" /old_locus_tag="BSU24380" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1766372, 15028710, 17693505, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766372, 15028710, 17693505, 28784753; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage III sporulation protein (feeding tube apparatus)" /protein_id="NP_390318.1" /db_xref="EnsemblGenomes-Gn:BSU24380" /db_xref="EnsemblGenomes-Tr:CAB14369" /db_xref="GOA:P49783" /db_xref="InterPro:IPR014245" /db_xref="SubtiList:BG11413" /db_xref="UniProtKB/Swiss-Prot:P49783" /translation="MSFLTEWLTTIVLFILFAIVIDMLLPSSSMQKYAKMVVSLLLIV VMLTPIFKLFKTDPEVIFEYLTKNGQSESADIKNQINSKKIEIQASQRAYILEEMAVQ LKKKAEERFSHDEYKVGRIKLTAGEKVDSEEDIKTISVYMAPSSEKTVQTVAPVHIDT DHAYVTKEAAEQKEAKQIQTQLADIWEIGSEKITVHMEGGESVGNE*" /label="spoIIIAF CDS" gene complement(2203106..2203726) /gene="spoIIIAF" /locus_tag="BSU_24380" /old_locus_tag="BSU24380" /label="spoIIIAF gene" promotor_-10 complement(2203432..2203450) /Source="Nicolas_upshift_promotors" /id="U1899" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=981 /SigmaFactorBS="tctgccgacataaaaaatcaaatcaattcaaaaaaaataGAA ATAcaagcttcccagcgcGCATATATTCTAGAAGAAAtggctgtccaactaaaaaaga a" /listShort="spoIIIAG, spoIIIAH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2203450) /Source="Nicolas_upshifts" /id="U1899" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=981 /SigmaFactorBS="tctgccgacataaaaaatcaaatcaattcaaaaaaaataGAA ATAcaagcttcccagcgcGCATATATTCTAGAAGAAAtggctgtccaactaaaaaaga a" /listShort="spoIIIAG, spoIIIAH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2203466..2203471) /Source="Nicolas_upshift_promotors" /id="U1899" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=981 /SigmaFactorBS="tctgccgacataaaaaatcaaatcaattcaaaaaaaataGAA ATAcaagcttcccagcgcGCATATATTCTAGAAGAAAtggctgtccaactaaaaaaga a" /listShort="spoIIIAG, spoIIIAH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2203740..2204939) /gene="spoIIIAE" /locus_tag="BSU_24390" /old_locus_tag="BSU24390" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1766372, 15028710, 15849754, 16850406, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766372, 15028710, 15849754, 16850406, 28784753; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage III sporulation protein (feeding tube apparatus)" /protein_id="NP_390319.2" /db_xref="EnsemblGenomes-Gn:BSU24390" /db_xref="EnsemblGenomes-Tr:CAB14370" /db_xref="GOA:P49782" /db_xref="InterPro:IPR014194" /db_xref="SubtiList:BG11412" /db_xref="UniProtKB/Swiss-Prot:P49782" /translation="MKRFQWVLLLAVLIIAGRAEIVQAAGNAEQTEDHAETAEQLAER TAASLETDKIGEFWNDIMTEYGGLLPESQKGSLMEFINGDKSFSPQEWLKALFSYLFH EVLANGKLLGTLILLTIFCVILQLLQNAFQQSTVSKVAYSIVYMVLIILALNSFHVAI NYATEAIQTMTSFILALIPLLLALLASSGGAVSAAFFHPVILFLMNTSGLLIQNIVMP LIFLSAILSIVSTMTEQYKVTQLANLLRNIAIGALAVFLTIFLGVISVQGASAAVTDG ITLRTAKFITGNFIPVLGRMFTDATDTVISASLLLKNTVGILGVAILICIAAFPAIKV LSLAFIYKLAAAILQPLGGGPVITCLDVISKSVIYIFAALAIVSLMFFLSLTVIITAG NLTMMMK*" /label="spoIIIAE CDS" gene complement(2203740..2204939) /gene="spoIIIAE" /locus_tag="BSU_24390" /old_locus_tag="BSU24390" /label="spoIIIAE gene" CDS complement(2204958..2205359) /gene="spoIIIAD" /locus_tag="BSU_24400" /old_locus_tag="BSU24400" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1766372, 15028710, 15849754, 16850406, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766372, 15028710, 15849754, 16850406, 28784753; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage III sporulation protein (feeding tube apparatus)" /protein_id="NP_390320.1" /db_xref="EnsemblGenomes-Gn:BSU24400" /db_xref="EnsemblGenomes-Tr:CAB14371" /db_xref="GOA:P49781" /db_xref="InterPro:IPR014211" /db_xref="InterPro:IPR025664" /db_xref="SubtiList:BG11411" /db_xref="UniProtKB/Swiss-Prot:P49781" /translation="MQIDIVQIVGLGLIATFLSLIVKEQKPTFAFLIVVFAGCAIFLY LVDQIYDIIRMIEKIAINANVNMVYVETILKIIGIAYIAEFGAQLTKDAGQGAIASKI ELAGKILILVMAVPILTVIIETILGLIPSMS*" /label="spoIIIAD CDS" gene complement(2204958..2205359) /gene="spoIIIAD" /locus_tag="BSU_24400" /old_locus_tag="BSU24400" /label="spoIIIAD gene" CDS complement(2205366..2205572) /gene="spoIIIAC" /locus_tag="BSU_24410" /old_locus_tag="BSU24410" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1766372, 15028710, 17693505, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766372, 15028710, 17693505, 28784753; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage III sporulation protein (feeding tube apparatus)" /protein_id="NP_390321.1" /db_xref="EnsemblGenomes-Gn:BSU24410" /db_xref="EnsemblGenomes-Tr:CAB14372" /db_xref="GOA:P49780" /db_xref="InterPro:IPR009570" /db_xref="InterPro:IPR025664" /db_xref="SubtiList:BG11410" /db_xref="UniProtKB/Swiss-Prot:P49780" /translation="MGVDVNVIFQIAGVGIVVAFLHTILDQMGKKEYAQWVTLLGFIY ILFMVATIVDDLFKKIKAVFLFQG*" /label="spoIIIAC CDS" gene complement(2205366..2205572) /gene="spoIIIAC" /locus_tag="BSU_24410" /old_locus_tag="BSU24410" /label="spoIIIAC gene" CDS complement(2205595..2206110) /gene="spoIIIAB" /locus_tag="BSU_24420" /old_locus_tag="BSU24420" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1766372, 15028710, 17693505, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766372, 15028710, 17693505, 28784753; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage III sporulation protein (feeding tube apparatus)" /protein_id="NP_390322.1" /db_xref="EnsemblGenomes-Gn:BSU24420" /db_xref="EnsemblGenomes-Tr:CAB14373" /db_xref="GOA:Q01368" /db_xref="InterPro:IPR014198" /db_xref="SubtiList:BG10541" /db_xref="UniProtKB/Swiss-Prot:Q01368" /translation="MLKLLGAVFIVVATTWTGFEMAKIYTERPRQIRQLRAALQSLEA EIMYGHTPLHTASQQIAKQLAQPVSTLFSAFSDQLDKGSDSAKTAWEQSLKKVWDTLS LKKSEYEVLKQFGETLGIHDRISQQKHIKLALTHLEASEADAEQAQAKNEKMIKSLGF LAGLLLILLLM*" /label="spoIIIAB CDS" gene complement(2205595..2206110) /gene="spoIIIAB" /locus_tag="BSU_24420" /old_locus_tag="BSU24420" /label="spoIIIAB gene" CDS complement(2206104..2207027) /gene="spoIIIAA" /locus_tag="BSU_24430" /old_locus_tag="BSU24430" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1766372, 15028710, 17693505, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766372, 15028710, 17693505, 28784753; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="ATP-binding stage III sporulation protein" /protein_id="NP_390323.1" /db_xref="EnsemblGenomes-Gn:BSU24430" /db_xref="EnsemblGenomes-Tr:CAB14374" /db_xref="GOA:Q01367" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR014217" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10540" /db_xref="UniProtKB/Swiss-Prot:Q01367" /translation="MNEIAEVLPESMKNALSEIPEQQWLEIEEVRIRINRPVELIRRG QPVYLSYAGTAEDAHLILSRLSNYSMYTLEEELKKGYVTIRGGHRVGLAGRVITENGG VKGLRDIASFNIRIARQKLGIAEPLLPYLYQNSWLNTLIIGPPQTGKTTLLRDLARLS STGKKNMLPVKTGIVDERSEIAGCLRGIPQHQFGQRIDVLDACPKAEGLMMMIRSMSP EVMIVDEIGRMEDTDALLEALHAGVSVIVSAHGWSISDLMKRPSLKRLWEERAFDRYL ELSRAKGPGTVSQIYDKDGNVLSRTTGVKTC*" /label="spoIIIAA CDS" gene complement(2206104..2207027) /gene="spoIIIAA" /locus_tag="BSU_24430" /old_locus_tag="BSU24430" /label="spoIIIAA gene" S_feature complement(2207028..2207102) /Source="Nicolas_S_feature" /locus_tag="new_2537614_2537688_c" /HighExp="S3, LoTm, S4, T5.0H, M9-stat, S5, BT, S7, S6, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S919" CDS complement(2207103..2207384) /gene="yqhV" /locus_tag="BSU_24440" /old_locus_tag="BSU24440" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390324.1" /db_xref="EnsemblGenomes-Gn:BSU24440" /db_xref="EnsemblGenomes-Tr:CAB14375" /db_xref="GOA:P49779" /db_xref="InterPro:IPR020390" /db_xref="SubtiList:BG11459" /db_xref="UniProtKB/Swiss-Prot:P49779" /translation="MKFLLGNINSTVLTMAGLRVLSSMIELTAAIVMLVTNDVRKAVV VNSILAIVGPLIFIITMTVGIYQIAGQLSYAKLILIFTGVVLILAGVHK*" /label="yqhV CDS" gene complement(2207103..2207384) /gene="yqhV" /locus_tag="BSU_24440" /old_locus_tag="BSU24440" /label="yqhV gene" promotor_-10 complement(2207404..2207422) /Source="Nicolas_upshift_promotors" /id="U1900" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=992 /SigmaFactorBS="ttttgtgcccaaaaacagaatctttcttttatacgaaaatga caAGACTActtcagcaagctagaGCATATCATATAAAAAAATgggaggttgggagagt g" /listShort="yqhV, S919, spoIIIAA, spoIIIAB, spoIIIAC, spoIIIAD, spoIIIAE, spoIIIAF" /listLong="spoIIIAG, spoIIIAH" /label="promotor_-10" upshifts complement(2207427) /Source="Nicolas_upshifts" /id="U1900" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=992 /SigmaFactorBS="ttttgtgcccaaaaacagaatctttcttttatacgaaaatga caAGACTActtcagcaagctagaGCATATCATATAAAAAAATgggaggttgggagagt g" /listShort="yqhV, S919, spoIIIAA, spoIIIAB, spoIIIAC, spoIIIAD, spoIIIAE, spoIIIAF" /listLong="spoIIIAG, spoIIIAH" /label="upshifts" promotor_-35 complement(2207438..2207443) /Source="Nicolas_upshift_promotors" /id="U1900" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=992 /SigmaFactorBS="ttttgtgcccaaaaacagaatctttcttttatacgaaaatga caAGACTActtcagcaagctagaGCATATCATATAAAAAAATgggaggttgggagagt g" /listShort="yqhV, S919, spoIIIAA, spoIIIAB, spoIIIAC, spoIIIAD, spoIIIAE, spoIIIAF" /listLong="spoIIIAG, spoIIIAH" /label="promotor_-35" CDS complement(2207529..2208086) /gene="efp" /locus_tag="BSU_24450" /old_locus_tag="BSU24450" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1956781, 14586115, 15066026, 15210970, 16014871, 27002156, 28787546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1956781, 14586115, 15066026, 15210970, 16014871, 27002156, 28787546; Product type f: factor" /codon_start=1 /transl_table=11 /product="elongation factor P" /protein_id="NP_390325.2" /db_xref="EnsemblGenomes-Gn:BSU24450" /db_xref="EnsemblGenomes-Tr:CAB14376" /db_xref="GOA:P49778" /db_xref="InterPro:IPR001059" /db_xref="InterPro:IPR008991" /db_xref="InterPro:IPR011768" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR013185" /db_xref="InterPro:IPR013852" /db_xref="InterPro:IPR014722" /db_xref="InterPro:IPR015365" /db_xref="InterPro:IPR020599" /db_xref="SubtiList:BG11460" /db_xref="UniProtKB/Swiss-Prot:P49778" /translation="MISVNDFRTGLTIEVDGGIWRVVDFQHVKPGKGAAFVRSKLRNL RTGAIQEKTFRAGEKVAKAQIETKTMQYLYANGDQHVFMDTSSYEQLELSATQIEEEL KYLLENMSVHIMMYQDETLGIELPNTVELKVVETEPGIKGDTASGGTKPAKTETGLVV NVPFFVNEGDTLVVNTSDGSYVSRA*" /label="efp CDS" gene complement(2207529..2208086) /gene="efp" /locus_tag="BSU_24450" /old_locus_tag="BSU24450" /label="efp gene" downshifts complement(2207541) /Source="Nicolas_upshifts" /id="D1271" /incds=0 /nref=256 /ntot=266 /MaxReadThrough="0.83852" /MaxDrop="7.73118" /score="27.4193827" /energy="-13.5" /TU="NA" /idTUdmin="U1901" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2208111..2209172) /gene="papA" /locus_tag="BSU_24460" /old_locus_tag="BSU24460" /EC_number="3.4.-.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:23144141, 26735940, 27002156" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23144141, 26735940, 27002156; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aminopeptidase (Met-Xaa and Xaa-Pro, Xaa-Pro-Xaa)" /protein_id="NP_390326.1" /db_xref="EnsemblGenomes-Gn:BSU24460" /db_xref="EnsemblGenomes-Tr:CAB14377" /db_xref="GOA:P54518" /db_xref="InterPro:IPR000587" /db_xref="InterPro:IPR000994" /db_xref="InterPro:IPR001131" /db_xref="InterPro:IPR001714" /db_xref="InterPro:IPR029149" /db_xref="InterPro:IPR036005" /db_xref="SubtiList:BG11708" /db_xref="UniProtKB/Swiss-Prot:P54518" /translation="MKLEKLRNLFGQLGIDGMLITSNTNVRYMTGFTGSAGLAVISGD KAAFITDFRYTEQAKVQVKGFEIIEHGGSLIQTTADTVESFGIKRLGFEQNSMTYGTY ASYSAVISDAELVPVAESVEKLRLIKSSEEIKILEEAAKIADDAFRHILTFMKPGISE IAVANELEFYMRSQGADSSSFDMIVASGLRSSLPHGVASDKLIESGDLVTLDFGAYYK GYCSDITRTVAVGQPSDQLKEIYQVVFDAQALGVAHIKPGMTGKEADALTRDHIAAKG YGDYFGHSTGHGLGMEVHESPGLSVRSSAILEPGMVVTVEPGIYIPETGGVRIEDDIV ITENGNRTITHSPKELIIL*" /label="papA CDS" gene complement(2208111..2209172) /gene="papA" /locus_tag="BSU_24460" /old_locus_tag="BSU24460" /label="papA gene" CDS complement(2209169..2209615) /gene="yqhS" /locus_tag="BSU_24470" /old_locus_tag="BSU24470" /EC_number="4.2.1.10" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10870960, 19099550; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-dehydroquinate dehydratase, type II" /protein_id="NP_390327.1" /db_xref="EnsemblGenomes-Gn:BSU24470" /db_xref="EnsemblGenomes-Tr:CAB14378" /db_xref="GOA:P54517" /db_xref="InterPro:IPR001874" /db_xref="InterPro:IPR018509" /db_xref="InterPro:IPR036441" /db_xref="PDB:1GQO" /db_xref="SubtiList:BG11707" /db_xref="UniProtKB/Swiss-Prot:P54517" /translation="MPHFLILNGPNVNRLGSREPEVFGRQTLTDIETDLFQFAEALHI QLTFFQSNHEGDLIDAIHEAEEQYSGIVLNPGALSHYSYAIRDAVSSISLPVVEVHLS NLYAREEFRHQSVIAPVAKGQIVGLGAEGYKLAVRYLLSQQGGESR*" /label="yqhS CDS" gene complement(2209169..2209615) /gene="yqhS" /locus_tag="BSU_24470" /old_locus_tag="BSU24470" /label="yqhS gene" promotor_-10 complement(2209664..2209683) /Source="Nicolas_upshift_promotors" /id="U1901" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.485514485514486" /psig="0.999000999001" /xcortree=2230 /SigmaFactorBS="gaaaagcttgcacgtgcgctgggaatgcatagagaatAGTGT ATAatccttttccagTATGATAAAATGTTCACGAGaagtgaacattttttacatgaga a" /listShort="yqhS, yqhT, efp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2209680) /Source="Nicolas_upshifts" /id="U1901" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.485514485514486" /psig="0.999000999001" /xcortree=2230 /SigmaFactorBS="gaaaagcttgcacgtgcgctgggaatgcatagagaatAGTGT ATAatccttttccagTATGATAAAATGTTCACGAGaagtgaacattttttacatgaga a" /listShort="yqhS, yqhT, efp" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2209696..2209703) /Source="Nicolas_upshift_promotors" /id="U1901" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.485514485514486" /psig="0.999000999001" /xcortree=2230 /SigmaFactorBS="gaaaagcttgcacgtgcgctgggaatgcatagagaatAGTGT ATAatccttttccagTATGATAAAATGTTCACGAGaagtgaacattttttacatgaga a" /listShort="yqhS, yqhT, efp" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2209702..2210238) /gene="yqhR" /locus_tag="BSU_24480" /old_locus_tag="BSU24480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390328.1" /db_xref="EnsemblGenomes-Gn:BSU24480" /db_xref="EnsemblGenomes-Tr:CAB14379" /db_xref="GOA:P54516" /db_xref="InterPro:IPR024563" /db_xref="SubtiList:BG11706" /db_xref="UniProtKB/Swiss-Prot:P54516" /translation="MMTSEKDTEQNEELNEKQKPPVSMAGRVAATGFCGGVLWSFVAY IAYLFHFSEISPNMILQPFVLGEWKKHGLGTVISIILIGVISIGAAFLYFLLLKRLKT MWPGILYGLVLWLLVFFVFNPIFPDVRTVTELTSDTIITTICIYLLYGLFVGYSISFE YNELNSEKLARALGMHRE*" /label="yqhR CDS" gene complement(2209702..2210238) /gene="yqhR" /locus_tag="BSU_24480" /old_locus_tag="BSU24480" /label="yqhR gene" promotor_-10 complement(2210251..2210262) /Source="Nicolas_upshift_promotors" /id="U1902" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=905 /SigmaFactorBS="caaattttactcgcagctgccaaaaagtgtgagcttttTTAT TGAcatttcattttttGGGCACACTTTAactggaggtgccatgatgacaagcgaaaaa g" /listShort="yqhR" /listLong="yqhS, yqhT, efp" /label="promotor_-10" upshifts complement(2210260) /Source="Nicolas_upshifts" /id="U1902" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=905 /SigmaFactorBS="caaattttactcgcagctgccaaaaagtgtgagcttttTTAT TGAcatttcattttttGGGCACACTTTAactggaggtgccatgatgacaagcgaaaaa g" /listShort="yqhR" /listLong="yqhS, yqhT, efp" /label="upshifts" promotor_-35 complement(2210276..2210282) /Source="Nicolas_upshift_promotors" /id="U1902" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=905 /SigmaFactorBS="caaattttactcgcagctgccaaaaagtgtgagcttttTTAT TGAcatttcattttttGGGCACACTTTAactggaggtgccatgatgacaagcgaaaaa g" /listShort="yqhR" /listLong="yqhS, yqhT, efp" /label="promotor_-35" promotor_-35 2210308..2210314 /Source="Nicolas_upshift_promotors" /id="U1903" /multdbtbs="SigB,SigF" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=746 /SigmaFactorBS="aatgaaatgtcaataaaaaagctcacactttttggcagctgC GAGTAAaatttgaaaataacGGGTATAATGCATGTAGAAaaagcaaggctatggcaat t" /listShort="yqhQ, yqhP" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2210327 /Source="Nicolas_upshifts" /id="U1903" /multdbtbs="SigB,SigF" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=746 /SigmaFactorBS="aatgaaatgtcaataaaaaagctcacactttttggcagctgC GAGTAAaatttgaaaataacGGGTATAATGCATGTAGAAaaagcaaggctatggcaat t" /listShort="yqhQ, yqhP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2210329..2210347 /Source="Nicolas_upshift_promotors" /id="U1903" /multdbtbs="SigB,SigF" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=746 /SigmaFactorBS="aatgaaatgtcaataaaaaagctcacactttttggcagctgC GAGTAAaatttgaaaataacGGGTATAATGCATGTAGAAaaagcaaggctatggcaat t" /listShort="yqhQ, yqhP" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2210384..2210387 /Source="Nicolas_upshift_promotors" /id="U1904" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=3141 /SigmaFactorBS="aaggctatggcaattttttcagcctgtcaatCTAGaggttta gcgctgtTTCCTGTACAATAGAGTGAAaggaaatggttagcaatcctaaagaaatagg c" /listShort="yqhQ, yqhP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2210402..2210421 /Source="Nicolas_upshift_promotors" /id="U1904" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=3141 /SigmaFactorBS="aaggctatggcaattttttcagcctgtcaatCTAGaggttta gcgctgtTTCCTGTACAATAGAGTGAAaggaaatggttagcaatcctaaagaaatagg c" /listShort="yqhQ, yqhP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2210413 /Source="Nicolas_upshifts" /id="U1904" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=3141 /SigmaFactorBS="aaggctatggcaattttttcagcctgtcaatCTAGaggttta gcgctgtTTCCTGTACAATAGAGTGAAaggaaatggttagcaatcctaaagaaatagg c" /listShort="yqhQ, yqhP" /GFF_Attribute="listLong" /label="upshifts" CDS 2210465..2211421 /gene="yqhQ" /locus_tag="BSU_24490" /old_locus_tag="BSU24490" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390329.2" /db_xref="EnsemblGenomes-Gn:BSU24490" /db_xref="EnsemblGenomes-Tr:CAB14380" /db_xref="GOA:P54515" /db_xref="InterPro:IPR010787" /db_xref="SubtiList:BG11705" /db_xref="UniProtKB/Swiss-Prot:P54515" /translation="MSKHKVPPAYGGQAVVEGVMFGGKHHYVTAIRRTDGSIDFFKLP RKHNPKLNIVKKIPFLRGIAAIIEASANGTKHLNFSSERYGLDPSEDETLEQEEKKSS GLSMYLSLAVIGVLSFLFSKFVFTLVPVFLAELTRPIFSLNTAQIAIESLFKLILLLG YIYFLSMTPLIKRVFQYHGAEHKVINCYEQNLPITVENVQNQSRLHYRCGSSFILFTI IVGMFVYLLVPTDPLWLRVIDRVALIPVVLGISFEVLQLTNKVRDIPGLKLLGYPGLW LQLLTTKEPKDEQVEVAIESFNELLRLEALSEQNQKPSHNVI*" /label="yqhQ CDS" gene 2210465..2211421 /gene="yqhQ" /locus_tag="BSU_24490" /old_locus_tag="BSU24490" /label="yqhQ gene" CDS 2211461..2211856 /gene="yqhP" /locus_tag="BSU_24500" /old_locus_tag="BSU24500" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390330.1" /db_xref="EnsemblGenomes-Gn:BSU24500" /db_xref="EnsemblGenomes-Tr:CAB14381" /db_xref="GOA:P54514" /db_xref="SubtiList:BG11704" /db_xref="UniProtKB/Swiss-Prot:P54514" /translation="MNHRVQPIIAVLIALGAFGFLYVLVTNPGEMAKMAVTVIVAGII IYFIVKYVMNRNAGSEGAAFKKAAKQSRRRMKEQKAKHRAGHKGRVSHLRSVPSASKP KPMILKKKSQTQLTVIEGKKNKKKNRALF*" /label="yqhP CDS" gene 2211461..2211856 /gene="yqhP" /locus_tag="BSU_24500" /old_locus_tag="BSU24500" /label="yqhP gene" promotor_no_box 2211739..2211839 /Source="Nicolas_upshift_promotors" /id="U1905" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.578421578421578" /psig="0.007992007992008" /xcortree=275 /SigmaFactorBS="gcgaagcgttccgagcgccagcaagcctaagccgatgattct caagaaaaaaagccagactcagctgactgttatagaagggaaaaaaaataaaaagaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 2211799 /Source="Nicolas_upshifts" /id="U1905" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.578421578421578" /psig="0.007992007992008" /xcortree=275 /SigmaFactorBS="gcgaagcgttccgagcgccagcaagcctaagccgatgattct caagaaaaaaagccagactcagctgactgttatagaagggaaaaaaaataaaaagaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2211842 /Source="Nicolas_upshifts" /id="D1272" /incds=0 /nref=116 /ntot=283 /MaxReadThrough="2.23161" /MaxDrop="5.94415" /score="29.0609078" /energy="-8" /TU="NA" /idTUdmin="U1903" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2211853..2212728) /gene="yqhO" /locus_tag="BSU_24510" /old_locus_tag="BSU24510" /EC_number="3.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lipase / acyl esterase" /protein_id="NP_390331.1" /db_xref="EnsemblGenomes-Gn:BSU24510" /db_xref="EnsemblGenomes-Tr:CAB14382" /db_xref="GOA:P54513" /db_xref="InterPro:IPR002641" /db_xref="InterPro:IPR016035" /db_xref="SubtiList:BG11703" /db_xref="UniProtKB/Swiss-Prot:P54513" /translation="MYIDGVFSGGGVKGIALAGAYEVLEEKGFRFKRVAGTSAGAIIA AFIASGYTSKEIHALIEEVDGEKLLDQRYSFLPLKMLQWVSIYWRLGLYKGDTIEKWI ADLLRAKGIRVFGDLQKGSLRLIASDLTNGTMIVLPDDLARYGLNPDMFPVARAVRMS CSIPYFFEPIKLKTDTGTATVVDGGVLSNFPIWLFSKERKRPVIGVTLAPRERERPKK NIRNAFELFGALFETMKDAHDARHIASRYEQNIIFLPVDDVMATDFHLTQQKKLALIE LGKRRTELFLKQWTY*" /label="yqhO CDS" gene complement(2211853..2212728) /gene="yqhO" /locus_tag="BSU_24510" /old_locus_tag="BSU24510" /label="yqhO gene" promotor_-10 complement(2212755..2212773) /Source="Nicolas_upshift_promotors" /id="U1906" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1086 /SigmaFactorBS="cgtcttttttgatacgctgacgccacccgtcattcgttGGTC TAtttcttcgcgtgtttTCTTAAAATGGTAATAAACgatcggatggagggggagggaa t" /listShort="yqhO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2212772) /Source="Nicolas_upshifts" /id="U1906" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1086 /SigmaFactorBS="cgtcttttttgatacgctgacgccacccgtcattcgttGGTC TAtttcttcgcgtgtttTCTTAAAATGGTAATAAACgatcggatggagggggagggaa t" /listShort="yqhO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2212789..2212794) /Source="Nicolas_upshift_promotors" /id="U1906" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1086 /SigmaFactorBS="cgtcttttttgatacgctgacgccacccgtcattcgttGGTC TAtttcttcgcgtgtttTCTTAAAATGGTAATAAACgatcggatggagggggagggaa t" /listShort="yqhO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2212854..2213282) /gene="mntR" /locus_tag="BSU_24520" /old_locus_tag="BSU24520" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12950915, 15948947, 16533030, 17118401, 17176058, 17342524, 27748968, 28223356" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12950915, 15948947, 16533030, 17118401, 17176058, 17342524, 27748968, 28223356; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (hydrogen peroxide sensing, allosterically regulated by Mn2+)" /protein_id="NP_390332.2" /db_xref="EnsemblGenomes-Gn:BSU24520" /db_xref="EnsemblGenomes-Tr:CAB14383" /db_xref="GOA:P54512" /db_xref="InterPro:IPR001367" /db_xref="InterPro:IPR022687" /db_xref="InterPro:IPR022689" /db_xref="InterPro:IPR022897" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="InterPro:IPR036421" /db_xref="PDB:1ON1" /db_xref="PDB:1ON2" /db_xref="PDB:2EV0" /db_xref="PDB:2EV5" /db_xref="PDB:2EV6" /db_xref="PDB:2F5C" /db_xref="PDB:2F5D" /db_xref="PDB:2F5E" /db_xref="PDB:2F5F" /db_xref="PDB:2HYF" /db_xref="PDB:2HYG" /db_xref="PDB:3R60" /db_xref="PDB:3R61" /db_xref="PDB:4HV5" /db_xref="PDB:4HV6" /db_xref="PDB:4HX4" /db_xref="PDB:4HX7" /db_xref="PDB:4HX8" /db_xref="SubtiList:BG11702" /db_xref="UniProtKB/Swiss-Prot:P54512" /translation="MTTPSMEDYIEQIYMLIEEKGYARVSDIAEALAVHPSSVTKMVQ KLDKDEYLIYEKYRGLVLTSKGKKIGKRLVYRHELLEQFLRIIGVDEEKIYNDVEGIE HHLSWNSIDRIGDLVQYFEEDDARKKDLKSIQKKTEHHNQ*" /label="mntR CDS" gene complement(2212854..2213282) /gene="mntR" /locus_tag="BSU_24520" /old_locus_tag="BSU24520" /label="mntR gene" downshifts complement(2212881) /Source="Nicolas_upshifts" /id="D1273" /incds=0 /nref=322 /ntot=333 /MaxReadThrough="2.568" /MaxDrop="7.28707" /score="15.888362" /energy="-12" /TU="NA" /idTUdmin="U1908" /TUdmin=6 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2213317..2213336) /Source="Nicolas_upshift_promotors" /id="U1907" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2459 /SigmaFactorBS="gtaaacagggcttttgacccgcggagcatCCTTGttttttca agttcatTAGTGTAAACTTGTAATGGTttataaagttaaggtgctttttgggagggtt t" /listShort="mntR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2213325) /Source="Nicolas_upshifts" /id="U1907" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2459 /SigmaFactorBS="gtaaacagggcttttgacccgcggagcatCCTTGttttttca agttcatTAGTGTAAACTTGTAATGGTttataaagttaaggtgctttttgggagggtt t" /listShort="mntR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2213352..2213356) /Source="Nicolas_upshift_promotors" /id="U1907" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2459 /SigmaFactorBS="gtaaacagggcttttgacccgcggagcatCCTTGttttttca agttcatTAGTGTAAACTTGTAATGGTttataaagttaaggtgctttttgggagggtt t" /listShort="mntR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2213382..2214218) /gene="lipM" /locus_tag="BSU_24530" /old_locus_tag="BSU24530" /EC_number="2.3.1.181" /function="3: Fatty acid and phospholipid metabolism" /experiment="publication(s) with functional evidences, PMID:20882995, 21338420, 21338421, 23960015" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20882995, 21338420, 21338421, 23960015; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein octanoyltransferase" /protein_id="NP_390333.1" /db_xref="EnsemblGenomes-Gn:BSU24530" /db_xref="EnsemblGenomes-Tr:CAB14384" /db_xref="GOA:P54511" /db_xref="InterPro:IPR004143" /db_xref="InterPro:IPR024898" /db_xref="SubtiList:BG11701" /db_xref="UniProtKB/Swiss-Prot:P54511" /translation="MQKETWRFIDSGNASPAFNMALDEALLYWHSEKKIPPVIRFYGW NPATLSVGYFQNIKKEINFEAVHKYNLGFVRRPTGGRGVLHDQELTYSVIVSEEHPEM PATVTEAYRVISEGILQGFRNLGLDAYFAIPRTEKEKESLKNPRSSVCFDAPSWYELV VEGRKVAGSAQTRQKGVILQHGSILLDLDEDKLFDLFLYPSERVRERMQRNFKNKAVA INELIEKRVTMDEARKAFKEGFETGLNIHLEPYELSQEELDFVHHLAETKYASDEWNY KR*" /label="lipM CDS" gene complement(2213382..2214218) /gene="lipM" /locus_tag="BSU_24530" /old_locus_tag="BSU24530" /label="lipM gene" promotor_-10 complement(2214242..2214261) /Source="Nicolas_upshift_promotors" /id="U1908" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.697302697302697" /psig="0.997002997002997" /xcortree=2353 /SigmaFactorBS="agcgtgattgtcatctataatggaactaaaaTATTTTTCatt ttcccgacagTTTGATAAACTGATTCTATTaaaacggtaaggaaggtcttaaaatgca a" /listShort="yqhM, mntR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2214253) /Source="Nicolas_upshifts" /id="U1908" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.697302697302697" /psig="0.997002997002997" /xcortree=2353 /SigmaFactorBS="agcgtgattgtcatctataatggaactaaaaTATTTTTCatt ttcccgacagTTTGATAAACTGATTCTATTaaaacggtaaggaaggtcttaaaatgca a" /listShort="yqhM, mntR" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2214255..2214799) /Source="Nicolas_S_feature" /locus_tag="new_2544841_2545385_c" /HighExp="Lbstat, LPhT, HiOs, M0t90, S1, M40t90, Sw, S0, B36, BC" /AntisenseName="yqhL" /AntisenseCor="-0.136624541005539" /AntisenseRegPval="-1.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S920" promotor_-35 complement(2214275..2214282) /Source="Nicolas_upshift_promotors" /id="U1908" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.697302697302697" /psig="0.997002997002997" /xcortree=2353 /SigmaFactorBS="agcgtgattgtcatctataatggaactaaaaTATTTTTCatt ttcccgacagTTTGATAAACTGATTCTATTaaaacggtaaggaaggtcttaaaatgca a" /listShort="yqhM, mntR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2214299..2214304 /Source="Nicolas_upshift_promotors" /id="U1909" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.458541458541459" /psig=1 /xcortree=2522 /SigmaFactorBS="caaactgtcgggaaaatgaaaaatattttagttccattataG ATGACaatcacgctgtgcTTTACTATAATAGTATTTGTcgaaaacggctctatgacct t" /listShort="S921, yqhL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2214318..2214337 /Source="Nicolas_upshift_promotors" /id="U1909" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.458541458541459" /psig=1 /xcortree=2522 /SigmaFactorBS="caaactgtcgggaaaatgaaaaatattttagttccattataG ATGACaatcacgctgtgcTTTACTATAATAGTATTTGTcgaaaacggctctatgacct t" /listShort="S921, yqhL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2214318 /Source="Nicolas_upshifts" /id="U1909" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.458541458541459" /psig=1 /xcortree=2522 /SigmaFactorBS="caaactgtcgggaaaatgaaaaatattttagttccattataG ATGACaatcacgctgtgcTTTACTATAATAGTATTTGTcgaaaacggctctatgacct t" /listShort="S921, yqhL" /GFF_Attribute="listLong" /label="upshifts" S_feature 2214329..2214408 /Source="Nicolas_S_feature" /locus_tag="new_2544915_2544994" /HighExp="dia15, H2O2, dia5, Diami, MG-0.2, G180, UNK1, LBGexp, Heat, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S921" CDS 2214409..2214789 /gene="yqhL" /locus_tag="BSU_24540" /old_locus_tag="BSU24540" /function="5.5: Sulfur metabolism" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11092948; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sulfur transferase" /protein_id="NP_390334.2" /db_xref="EnsemblGenomes-Gn:BSU24540" /db_xref="EnsemblGenomes-Tr:CAB14385" /db_xref="GOA:P54510" /db_xref="InterPro:IPR001763" /db_xref="InterPro:IPR036873" /db_xref="SubtiList:BG11700" /db_xref="UniProtKB/Swiss-Prot:P54510" /translation="MSNMIVLIIFAAFIIYMIASYVYQQRIMKTLTEEEFRAGYRKAQ LIDVREPNEFEGGHILGARNIPLSQLKQRKNEIRTDKPVYLYCQNSVRSGRAAQTLRK NGCTEIYNLKGGFKKWGGKIKAKK*" /label="yqhL CDS" gene 2214409..2214789 /gene="yqhL" /locus_tag="BSU_24540" /old_locus_tag="BSU24540" /label="yqhL gene" downshifts 2214725 /Source="Nicolas_upshifts" /id="D1274" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="6.17088" /MaxDrop="3.92673" /score="27.1863605" /energy="-12" /TU="U1909" /idTUdmin="U1909" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" downshifts 2214769 /Source="Nicolas_upshifts" /id="D1275" /incds=0 /nref=213 /ntot=249 /MaxReadThrough="2.26861" /MaxDrop="6.03848" /score="27.1863605" /energy="-12" /TU="NA" /idTUdmin="U1909" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2214824..2216290) /gene="gcvPB" /locus_tag="BSU_24550" /old_locus_tag="BSU24550" /EC_number="1.4.4.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8181752, 20011599, 22720735, 23721735, 29089431" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8181752, 20011599, 22720735, 23721735, 29089431; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycine decarboxylase (subunit 2) (glycine cleavage system protein P)" /protein_id="NP_390335.1" /db_xref="EnsemblGenomes-Gn:BSU24550" /db_xref="EnsemblGenomes-Tr:CAB14386" /db_xref="GOA:P54377" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR020581" /db_xref="InterPro:IPR023012" /db_xref="SubtiList:BG11511" /db_xref="UniProtKB/Swiss-Prot:P54377" /translation="MSNQDQALIFELSREGRIGYSLPELDVPEIELGDLLSDTYIRDE DAALPEVSELDIMRHYTALSKRNHGVDSGFYPLGSCTMKYNPKINEKIARIPGFAAIH PLQDEDTVQGALELLYDLSKHLEEITGMDEVTLQPAAGAHGEWTGLMMIRAYHEARGD FKRTKVIVPDSAHGTNPASATVAGFETVTVKSNEKGLVDLEDLKRAVNEETAALMLTN PNTLGLFEEQITEMAEIVHQAGGKLYYDGANLNAVLSKARPGDMGFDVVHLNLHKTFT GPHGGGGPGSGPVGVKQDLIPYLPKPVLVKKEGRFTFDYDRPHAIGRVKPYYGNFGIN VRAYTYIRSMGPDGLKAVTENAVLNANYMMRKLAPYYDLPFDRHCKHEFVLSGKRQKK LGVRTLDIAKRLLDFGYHPPTIYFPLNVEECIMIEPTETESKETLDAFIDAMIQIAKE AEENPELVQEAPHTTIVKRMDETKAARHPVLRYEAEER*" /label="gcvPB CDS" gene complement(2214824..2216290) /gene="gcvPB" /locus_tag="BSU_24550" /old_locus_tag="BSU24550" /label="gcvPB gene" downshifts complement(2214844) /Source="Nicolas_upshifts" /id="D1276" /incds=0 /nref=31 /ntot=215 /MaxReadThrough="3.45831" /MaxDrop="4.3142" /score="0.884126414" /energy="-12" /TU="U1911" /idTUdmin="U1911" /TUdmin="-1517" /isTUend="FALSE" /label="downshifts" CDS complement(2216283..2217629) /gene="gcvPA" /locus_tag="BSU_24560" /old_locus_tag="BSU24560" /EC_number="1.4.4.2" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8181752, 20011599, 23721735, 29089431; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycine decarboxylase (subunit 1) (glycine cleavage system protein P)" /protein_id="NP_390336.2" /db_xref="EnsemblGenomes-Gn:BSU24560" /db_xref="EnsemblGenomes-Tr:CAB14387" /db_xref="GOA:P54376" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR020581" /db_xref="InterPro:IPR023010" /db_xref="SubtiList:BG11510" /db_xref="UniProtKB/Swiss-Prot:P54376" /translation="MKHRYLPATEKDKQEMLATIGVSSIDDLFADIPENVKYKKEHQI KKAKSETELTRELTKLASKNRDTVQYASFLGAGVYDHYQPVIVDHVISRSEFYTAYTP YQPEISQGELQAIFEFQTMICELTGMDIANSSMYDGGTALAEAAMLASGHTKKKKIVV SKTVHPESREVLKTYAKGQYIDVVEVPAADGVTDLDALRQTVCENTAAVIVQYPNFFG RIEPLKDIEPIAHQGKSMFIVSANPLALGLLTPPGKFQSDIVVGDAQPFGIPSAYGGP HCGFFAVTKKLMRKVPGRLVGQTEDENGKRGFVLTLQAREQHIRRDKATSNICSNQAL NALAASVAMTALGKNGVKDIARQNLLKANYAKQEAKKAGLTVMFDGPMFNEFVIKLDE PVRAVNKRLLAKGMIGGYDLGLTYPELDCHMLIAVTELRTKEEIDALIQELGDRHE*" /label="gcvPA CDS" gene complement(2216283..2217629) /gene="gcvPA" /locus_tag="BSU_24560" /old_locus_tag="BSU24560" /label="gcvPA gene" CDS complement(2217659..2218747) /gene="gcvT" /locus_tag="BSU_24570" /old_locus_tag="BSU24570" /EC_number="2.1.2.10" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8219277, 15472076, 22720735, 23721735, 29089431" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8219277, 15472076, 22720735, 23721735, 29089431; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aminomethyltransferase (glycine cleavage system protein T)" /protein_id="NP_390337.2" /db_xref="EnsemblGenomes-Gn:BSU24570" /db_xref="EnsemblGenomes-Tr:CAB14388" /db_xref="GOA:P54378" /db_xref="InterPro:IPR006222" /db_xref="InterPro:IPR006223" /db_xref="InterPro:IPR013977" /db_xref="InterPro:IPR022903" /db_xref="InterPro:IPR028896" /db_xref="InterPro:IPR029043" /db_xref="PDB:1YX2" /db_xref="SubtiList:BG11509" /db_xref="UniProtKB/Swiss-Prot:P54378" /translation="MLKRTPLFDLYKEYGGKTIDFGGWELPVQFSSIKKEHEAVRTAA GLFDVSHMGEVEVSGNDSLSFLQRLMTNDVSALTPGRAQYTAMCYPDGGTVDDLLIYQ KGENRYLLVINASNIDKDLAWMKEHAAGDVQIDNQSDQIALLAVQGPKAEAILKNLTD ADVSALKPFAFIDEADISGRKALISRTGYTGEDGYEIYCRSDDAMHIWKKIIDAGDAY GLIPCGLGARDTLRFEAKLPLYGQELTRDITPIEAGIGFAVKHKKESDFFGKSVLSEQ KENGAKRKLVGLEMIEKGIPRHGYEVFQNGKSVGKVTTGTQSPTLGKNVGLALIDSET SEIGTVVDVEIRKKLVKAKVVKTPFYKR*" /label="gcvT CDS" gene complement(2217659..2218747) /gene="gcvT" /locus_tag="BSU_24570" /old_locus_tag="BSU24570" /label="gcvT gene" misc_RNA complement(2218821..2219020) /gene="swgA" /locus_tag="BSU_misc_RNA_37" /product="dual aptamer glycine riboswitch" /experiment="publication(s) with functional evidences, PMID:15472076, 21439473, 23249744, 23721735, 29089431" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15472076, 21439473, 23249744, 23721735, 29089431; Product type n: RNA" /label="swgA RNA" gene complement(2218821..2219020) /gene="swgA" /locus_tag="BSU_misc_RNA_37" /label="swgA gene" downshifts complement(2218871) /Source="Nicolas_upshifts" /id="D1277" /incds=0 /nref=1 /ntot=31 /MaxReadThrough="6.79606" /MaxDrop="3.0322" /score="21.5485037" /energy="-20.2" /TU="U1911" /idTUdmin="U1915" /TUdmin=3630 /isTUend="FALSE" /label="downshifts" S_feature complement(2219021..2219091) /Source="Nicolas_S_feature" /locus_tag="new_2549607_2549677_c" /HighExp="B60, S8, S6, B36, S7, M9-stat, Sw, T3.0H, HiOs, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S922" promotor_-35 2219024..2219029 /Source="Nicolas_upshift_promotors" /id="U1910" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.83016983016983" /psig="0.83016983016983" /xcortree=1074 /SigmaFactorBS="gttttcggtcaggtctctccccttgctgtcattcgCTCATAt tttcatgctgttatGGACATACTATAGCAATATcttacatcaaatacatactcatatc c" /listShort="S923, yqhH, yqhG, S924, sinI, sinR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2219045..2219063 /Source="Nicolas_upshift_promotors" /id="U1910" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.83016983016983" /psig="0.83016983016983" /xcortree=1074 /SigmaFactorBS="gttttcggtcaggtctctccccttgctgtcattcgCTCATAt tttcatgctgttatGGACATACTATAGCAATATcttacatcaaatacatactcatatc c" /listShort="S923, yqhH, yqhG, S924, sinI, sinR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2219049 /Source="Nicolas_upshifts" /id="U1910" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.83016983016983" /psig="0.83016983016983" /xcortree=1074 /SigmaFactorBS="gttttcggtcaggtctctccccttgctgtcattcgCTCATAt tttcatgctgttatGGACATACTATAGCAATATcttacatcaaatacatactcatatc c" /listShort="S923, yqhH, yqhG, S924, sinI, sinR" /GFF_Attribute="listLong" /label="upshifts" S_feature 2219059..2219188 /Source="Nicolas_S_feature" /locus_tag="new_2549645_2549774" /HighExp="S4, S8, S7, S3, S5, S6, LoTm, T5.0H, T4.0H, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.83" /TUlongSig="NA" /TUlongPSig="NA" /label="S923" promotor_-10 complement(2219077..2219096) /Source="Nicolas_upshift_promotors" /id="U1911" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.629370629370629" /psig="0.995004995004995" /xcortree=417 /SigmaFactorBS="gatgaataatataagaaaaatctgcccaaattgcTGTTGCCC agcatatagtgatGATGGTAGGATATGAGTATGtatttgatgtaagatattgctatag t" /listShort="S922, NA, NA, gcvT, gcvPA, gcvPB, S920, yqhM" /listLong="mntR" /label="promotor_-10" upshifts complement(2219091) /Source="Nicolas_upshifts" /id="U1911" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.629370629370629" /psig="0.995004995004995" /xcortree=417 /SigmaFactorBS="gatgaataatataagaaaaatctgcccaaattgcTGTTGCCC agcatatagtgatGATGGTAGGATATGAGTATGtatttgatgtaagatattgctatag t" /listShort="S922, NA, NA, gcvT, gcvPA, gcvPB, S920, yqhM" /listLong="mntR" /label="upshifts" promotor_-35 complement(2219110..2219117) /Source="Nicolas_upshift_promotors" /id="U1911" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.629370629370629" /psig="0.995004995004995" /xcortree=417 /SigmaFactorBS="gatgaataatataagaaaaatctgcccaaattgcTGTTGCCC agcatatagtgatGATGGTAGGATATGAGTATGtatttgatgtaagatattgctatag t" /listShort="S922, NA, NA, gcvT, gcvPA, gcvPB, S920, yqhM" /listLong="mntR" /label="promotor_-35" CDS 2219189..2220862 /gene="yqhH" /locus_tag="BSU_24580" /old_locus_tag="BSU24580" /EC_number="3.6.-.-" /function="16.3: Control" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA polymerase-associated helicase protein" /protein_id="NP_390338.1" /db_xref="EnsemblGenomes-Gn:BSU24580" /db_xref="EnsemblGenomes-Tr:CAB14389" /db_xref="GOA:P54509" /db_xref="InterPro:IPR000330" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11699" /db_xref="UniProtKB/Swiss-Prot:P54509" /translation="MNTEMIYDAKWPEEFAERLKNDGPWANWELYKLSAEIQKTLAIP EFEGLRAPLYLPSFTPLPHQLEVAQKVVEKMNGKAILADEVGLGKTVEAGLILKEYMI RGLAKKILILVPASLVSQWVKELQEKFLIPAVEQKKSYVWEQCDIVVSSIDTAKRSPH REIVLSIPYDLVIIDEAHKLKNSKTKNYEFVRNLVKKYCLLLTATPIQNRIEEIFNLV SLLKPGHLGSQNHFQEEFAKKKSSLEAHEHLKDLVNKVMIRNRRHDTGLNWKQRHVET VPIQFSPSEQALYDEISRLKDSINKPASMFSIMTLQRECCSSREAVYMTLKKMLDQKE KQAPAIDEDTISVLIDRINQVTQNSKALQVVDLIKKIDDKVIIFTEYRATQIYLQWFL QQNGISSVPFRGGFKRGKKDWMKDLFRGKIQVLIATEAGGEGINLQFCNHMINYDLPW NPMRLEQRIGRIHRLGQERDVHIYNMATKHTVEEHILKLLYEKIHLFEKVVGELDDIL TKIQVNNFEEHLHDILYHSATEEEMKIKMDNLTSFLSYKKQLPAEKRGS*" /label="yqhH CDS" gene 2219189..2220862 /gene="yqhH" /locus_tag="BSU_24580" /old_locus_tag="BSU24580" /label="yqhH gene" CDS 2220883..2221677 /gene="yqhG" /locus_tag="BSU_24590" /old_locus_tag="BSU24590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390339.1" /db_xref="EnsemblGenomes-Gn:BSU24590" /db_xref="EnsemblGenomes-Tr:CAB14390" /db_xref="InterPro:IPR024562" /db_xref="SubtiList:BG11698" /db_xref="UniProtKB/Swiss-Prot:P54508" /translation="MRQQEVHDFLLRFFQANSCQIVDQGLGYMTVQLTVEMDKQIMNR PFYWHWREKTGGDPNPMKITFITDKENAPKDLDGEFIYFGAPRLFQIFKAVKQNGRFT RMYEKIESAGAKVPLQPWLGINVTISYQSDMKKDKLLSLGLHLVSGTIIEDFQSKLTQ FSLTSQICDYCFTISPMIKPESGLKRMENYISKSAMQEPSDWAEQAVNRWKNDMTLLD KFYEHIEEKPEEYHLEKQALKTLYQPKISVEIENGGLFYLQNNISS*" /label="yqhG CDS" gene 2220883..2221677 /gene="yqhG" /locus_tag="BSU_24590" /old_locus_tag="BSU24590" /label="yqhG gene" misc_feature 2221213..2221214 /Source="Nicolas_upshift_promotors" /id="U1912" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.497502497502497" /psig="0.541458541458541" /xcortree=3205 /SigmaFactorBS="aaagctgttaaacaaaatgggagatttaccagaatgtatgag aaaattgaatcaGCcggagctaaagtcccacttcagccttggcttggtataaatgtca c" /GFF_Attribute="listShort" /listLong="S924, sinI, sinR" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2221219 /Source="Nicolas_upshifts" /id="U1912" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.497502497502497" /psig="0.541458541458541" /xcortree=3205 /SigmaFactorBS="aaagctgttaaacaaaatgggagatttaccagaatgtatgag aaaattgaatcaGCcggagctaaagtcccacttcagccttggcttggtataaatgtca c" /GFF_Attribute="listShort" /listLong="S924, sinI, sinR" /label="upshifts" promotor_-35 2221701..2221704 /Source="Nicolas_upshift_promotors" /id="U1913" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.667332667332667" /psig="0.843156843156843" /xcortree=965 /SigmaFactorBS="ataatatttcaagctaacttttttaccattcgacatcattCT CGttttttttgagaaaaTACGATTATAATAAAGGTATattggaaaaaaattctggtga t" /listShort="S924, sinI, sinR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2221720..2221739 /Source="Nicolas_upshift_promotors" /id="U1913" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.667332667332667" /psig="0.843156843156843" /xcortree=965 /SigmaFactorBS="ataatatttcaagctaacttttttaccattcgacatcattCT CGttttttttgagaaaaTACGATTATAATAAAGGTATattggaaaaaaattctggtga t" /listShort="S924, sinI, sinR" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2221721..2221859 /Source="Nicolas_S_feature" /locus_tag="new_2552307_2552445" /HighExp="LoTm, S4, S5, T5.0H, M9-stat, S3, B60, S7, T4.0H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="0.843, 0.83" /TUlongSig="SigA" /TUlongPSig="0.541" /label="S924" upshifts 2221721 /Source="Nicolas_upshifts" /id="U1913" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.667332667332667" /psig="0.843156843156843" /xcortree=965 /SigmaFactorBS="ataatatttcaagctaacttttttaccattcgacatcattCT CGttttttttgagaaaaTACGATTATAATAAAGGTATattggaaaaaaattctggtga t" /listShort="S924, sinI, sinR" /GFF_Attribute="listLong" /label="upshifts" CDS 2221860..2222033 /gene="sinI" /locus_tag="BSU_24600" /old_locus_tag="BSU24600" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8549812, 10547280, 11751836, 15661000, 15805512, 23569226, 25326308, 26434553, 28430084" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8549812, 10547280, 11751836, 15661000, 15805512, 23569226, 25326308, 26434553, 28430084; Product type r: regulator" /codon_start=1 /transl_table=11 /product="antagonist of SinR" /protein_id="NP_390340.1" /db_xref="EnsemblGenomes-Gn:BSU24600" /db_xref="EnsemblGenomes-Tr:CAB14391" /db_xref="GOA:P23308" /db_xref="InterPro:IPR010981" /db_xref="InterPro:IPR036281" /db_xref="PDB:1B0N" /db_xref="SubtiList:BG10753" /db_xref="UniProtKB/Swiss-Prot:P23308" /translation="MKNAKQEHFELDQEWVELMVEAKEANISPEEIRKYLLLNKKSAH PGPAARSHTVNPF*" /label="sinI CDS" gene 2221860..2222033 /gene="sinI" /locus_tag="BSU_24600" /old_locus_tag="BSU24600" /label="sinI gene" promotor_-35 2222018..2222022 /Source="Nicolas_upshift_promotors" /id="U1914" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3096 /SigmaFactorBS="acaaaaagtctgctcatcctggtccggcagccagaagtcata cCGTAAatcctttctgaaTGTGCTATAATATCACAAGGaaggtgatgacattgattgg c" /listShort="sinR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2222035..2222054 /Source="Nicolas_upshift_promotors" /id="U1914" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3096 /SigmaFactorBS="acaaaaagtctgctcatcctggtccggcagccagaagtcata cCGTAAatcctttctgaaTGTGCTATAATATCACAAGGaaggtgatgacattgattgg c" /listShort="sinR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2222035 /Source="Nicolas_upshifts" /id="U1914" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3096 /SigmaFactorBS="acaaaaagtctgctcatcctggtccggcagccagaagtcata cCGTAAatcctttctgaaTGTGCTATAATATCACAAGGaaggtgatgacattgattgg c" /listShort="sinR" /GFF_Attribute="listLong" /label="upshifts" CDS 2222067..2222402 /gene="sinR" /locus_tag="BSU_24610" /old_locus_tag="BSU24610" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15805512, 16585769, 16740951, 16923912, 21708175, 25326308, 26434553, 28546427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15805512, 16585769, 16740951, 16923912, 21708175, 25326308, 26434553, 28546427; Product type r: regulator" /codon_start=1 /transl_table=11 /product="master regulator of biofilm formation" /protein_id="NP_390341.1" /db_xref="EnsemblGenomes-Gn:BSU24610" /db_xref="EnsemblGenomes-Tr:CAB14392" /db_xref="GOA:P06533" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010981" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR036281" /db_xref="PDB:1B0N" /db_xref="PDB:2YAL" /db_xref="PDB:3QQ6" /db_xref="PDB:3ZKC" /db_xref="SubtiList:BG10754" /db_xref="UniProtKB/Swiss-Prot:P06533" /translation="MIGQRIKQYRKEKGYSLSELAEKAGVAKSYLSSIERNLQTNPSI QFLEKVSAVLDVSVHTLLDEKHETEYDGQLDSEWEKLVRDAMTSGVSKKQFREFLDYQ KWRKSQKEE*" /label="sinR CDS" gene 2222067..2222402 /gene="sinR" /locus_tag="BSU_24610" /old_locus_tag="BSU24610" /label="sinR gene" downshifts 2222379 /Source="Nicolas_upshifts" /id="D1278" /incds=0 /nref=21 /ntot=181 /MaxReadThrough="4.7611" /MaxDrop="6.41889" /score="2.30357781" /energy="-20" /TU="U1913,U1914" /idTUdmin="U1910" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" downshifts 2222469 /Source="Nicolas_upshifts" /id="D1279" /incds=0 /nref=1 /ntot=85 /MaxReadThrough="2.4376" /MaxDrop="4.25363" /score="58.1462301" /energy="-26.8" /TU="NA" /idTUdmin="U1913" /TUdmin=22 /isTUend="TRUE" /label="downshifts" CDS complement(2222495..2223280) /gene="tasA" /locus_tag="BSU_24620" /old_locus_tag="BSU24620" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10464223, 10827084, 16430695, 16430696, 18047568, 23569226, 25326308, 27655338, 28546427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10464223, 10827084, 16430695, 16430696, 18047568, 23569226, 25326308, 27655338, 28546427; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="major biofilm matrix component" /protein_id="NP_390342.1" /db_xref="EnsemblGenomes-Gn:BSU24620" /db_xref="EnsemblGenomes-Tr:CAB14393" /db_xref="GOA:P54507" /db_xref="InterPro:IPR022121" /db_xref="InterPro:IPR023833" /db_xref="SubtiList:BG11697" /db_xref="UniProtKB/Swiss-Prot:P54507" /translation="MGMKKKLSLGVASAALGLALVGGGTWAAFNDIKSKDATFASGTL DLSAKENSASVNLSNLKPGDKLTKDFQFENNGSLAIKEVLMALNYGDFKANGGSNTSP EDFLSQFEVTLLTVGKEGGNGYPKNIILDDANLKDLYLMSAKNDAAAAEKIKKQIDPK FLNASGKVNVATIDGKTAPEYDGVPKTPTDFDQVQMEIQFKDDKTKDEKGLMVQNKYQ GNSIKLQFSFEATQWNGLTIKKDHTDKDGYVKENEKAHSEDKN*" /label="tasA CDS" gene complement(2222495..2223280) /gene="tasA" /locus_tag="BSU_24620" /old_locus_tag="BSU24620" /label="tasA gene" downshifts complement(2222501) /Source="Nicolas_upshifts" /id="D1280" /incds=0 /nref=144 /ntot=227 /MaxReadThrough="4.33009" /MaxDrop="8.70948" /score="10.0483516" /energy="-20" /TU="NA" /idTUdmin="U1915" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(2223333..2223350) /Source="Nicolas_upshift_promotors" /id="U1915" /multdbtbs="-" /comp="M14" /sig="Sig-" /pcomp="0.236763236763237" /psig="0.478521478521479" /xcortree=2768 /SigmaFactorBS="agaaagacaaaagccttggaaacagatacaaaggacagcacc atgtcTACTTAACTTCAGTTGTAaacctggcaacaggtttcgatataaaatcattcaa t" /listShort="tasA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2223337) /Source="Nicolas_upshifts" /id="U1915" /multdbtbs="-" /comp="M14" /sig="Sig-" /pcomp="0.236763236763237" /psig="0.478521478521479" /xcortree=2768 /SigmaFactorBS="agaaagacaaaagccttggaaacagatacaaaggacagcacc atgtcTACTTAACTTCAGTTGTAaacctggcaacaggtttcgatataaaatcattcaa t" /listShort="tasA" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2223344..2223916) /gene="sipW" /locus_tag="BSU_24630" /old_locus_tag="BSU24630" /EC_number="3.4.21.89" /function="16.1: Circulate" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10464223, 10559173, 10827084, 15101989, 16430695, 22328672, 26346121, 27655338" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10464223, 10559173, 10827084, 15101989, 16430695, 22328672, 26346121, 27655338; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="type I signal peptidase" /protein_id="NP_390343.1" /db_xref="EnsemblGenomes-Gn:BSU24630" /db_xref="EnsemblGenomes-Tr:CAB14394" /db_xref="GOA:P54506" /db_xref="InterPro:IPR001733" /db_xref="InterPro:IPR015927" /db_xref="InterPro:IPR036286" /db_xref="SubtiList:BG11696" /db_xref="UniProtKB/Swiss-Prot:P54506" /translation="MKLISNILYVIIFTLIIVLTLVVISTRSSGGEPAVFGYTLKSVL SGSMEPEFNTGSLILVKEITDVKELQKGDVITFMQDANTAVTHRIVDITKQGDHLLFK TKGDNNAAADSAPVSDENVRAQYTGFQLPYAGYMLHFASQPIGTAVLLIVPGVMLLVY AFVTISSAIREIERKTKALETDTKDSTMST*" /label="sipW CDS" gene complement(2223344..2223916) /gene="sipW" /locus_tag="BSU_24630" /old_locus_tag="BSU24630" /label="sipW gene" CDS complement(2223900..2224661) /gene="tapA" /locus_tag="BSU_24640" /old_locus_tag="BSU24640" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10464223, 10559173, 14707086, 16430695, 17554552, 21477127, 24488317, 26441856, 26819068, 27655338" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10464223, 10559173, 14707086, 16430695, 17554552, 21477127, 24488317, 26441856, 26819068, 27655338; Product type lp : lipoprotein" /codon_start=1 /transl_table=11 /product="lipoprotein for biofilm formation" /protein_id="NP_390344.1" /db_xref="EnsemblGenomes-Gn:BSU24640" /db_xref="EnsemblGenomes-Tr:CAB14395" /db_xref="GOA:P40949" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR023833" /db_xref="InterPro:IPR023848" /db_xref="SubtiList:BG11076" /db_xref="UniProtKB/Swiss-Prot:P40949" /translation="MFRLFHNQQKAKTKLKVLLIFQLSVIFSLTAAICLQFSDDTSAA FHDIETFDVSLQTCKDFQHTDKNCHYDKRWDQSDLHISDQTDTKGTVCSPFALFAVLE NTGEKLKKSKWKWELHKLENARKPLKDGNVIEKGFVSNQIGDSLYKIETKKKMKPGIY AFKVYKPAGYPANGSTFEWSEPMRLAKCDEKPTVPKKETKSDVKKENETTQKDIPEKT MKEETSQEAVTKEKETQSDQKESGEEDEKSNEADQ*" /label="tapA CDS" gene complement(2223900..2224661) /gene="tapA" /locus_tag="BSU_24640" /old_locus_tag="BSU24640" /label="tapA gene" promotor_-10 complement(2224721..2224740) /Source="Nicolas_upshift_promotors" /id="U1916" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig="0.97002997002997" /xcortree=2769 /SigmaFactorBS="aaaacattcttttaaacgaacaaaatgagcgatttcggTGTT TTTAaatctataaatcgTTGATTATACTCTATTTGTGaagttctttaaagagaacgat t" /listShort="yqxM, sipW" /listLong="tasA" /label="promotor_-10" upshifts complement(2224739) /Source="Nicolas_upshifts" /id="U1916" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig="0.97002997002997" /xcortree=2769 /SigmaFactorBS="aaaacattcttttaaacgaacaaaatgagcgatttcggTGTT TTTAaatctataaatcgTTGATTATACTCTATTTGTGaagttctttaaagagaacgat t" /listShort="yqxM, sipW" /listLong="tasA" /label="upshifts" promotor_-35 complement(2224754..2224761) /Source="Nicolas_upshift_promotors" /id="U1916" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig="0.97002997002997" /xcortree=2769 /SigmaFactorBS="aaaacattcttttaaacgaacaaaatgagcgatttcggTGTT TTTAaatctataaatcgTTGATTATACTCTATTTGTGaagttctttaaagagaacgat t" /listShort="yqxM, sipW" /listLong="tasA" /label="promotor_-35" promotor_-35 2224883..2224889 /Source="Nicolas_upshift_promotors" /id="U1917" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1137 /SigmaFactorBS="ctcattttttcaattttttagaaatttttgggattgttatgt gagaatttaaaTGCATATcccattattatttGGTAATAATAAAcaaagaaagggtgac a" /listShort="yqzG" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2224890 /Source="Nicolas_upshifts" /id="U1917" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1137 /SigmaFactorBS="ctcattttttcaattttttagaaatttttgggattgttatgt gagaatttaaaTGCATATcccattattatttGGTAATAATAAAcaaagaaagggtgac a" /listShort="yqzG" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2224903..2224914 /Source="Nicolas_upshift_promotors" /id="U1917" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1137 /SigmaFactorBS="ctcattttttcaattttttagaaatttttgggattgttatgt gagaatttaaaTGCATATcccattattatttGGTAATAATAAAcaaagaaagggtgac a" /listShort="yqzG" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2224933..2225259 /gene="yqzG" /locus_tag="BSU_24650" /old_locus_tag="BSU24650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_390345.1" /db_xref="EnsemblGenomes-Gn:BSU24650" /db_xref="EnsemblGenomes-Tr:CAB14396" /db_xref="InterPro:IPR024987" /db_xref="PDB:2LYX" /db_xref="SubtiList:BG13773" /db_xref="UniProtKB/Swiss-Prot:O32019" /translation="MMIKQCVICLSLLVFGTTAAHAEETPLVTARHMSKWEEIAVKEA KKRYPLAQVLFKQKVWDRKRKDEAVKQYHLTLREGSKEFGVFVTISFDPYSQKVNKIA ILEEYQ*" /label="yqzG CDS" gene 2224933..2225259 /gene="yqzG" /locus_tag="BSU_24650" /old_locus_tag="BSU24650" /label="yqzG gene" S_feature complement(2225076..2225300) /Source="Nicolas_S_feature" /locus_tag="new_2555662_2555886_c" /HighExp="GM 150, G/S, C30, T-4.40H, S8, T-3.40H, Pyr, S7, S2, C90" /AntisenseName="yqzG" /AntisenseCor="0.536702817178903" /AntisenseRegPval="-20.7" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.549, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S925" downshifts complement(2225119) /Source="Nicolas_upshifts" /id="D1281" /incds=1 /nref=92 /ntot=160 /MaxReadThrough="2.23218" /MaxDrop="5.56661" /score="31.27773" /energy="-10.2" /TU="NA" /idTUdmin="U1918" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 2225241 /Source="Nicolas_upshifts" /id="D1282" /incds=0 /nref=13 /ntot=41 /MaxReadThrough="2.14107" /MaxDrop="4.98052" /score="-9.62570043" /energy="-15.1" /TU="NA" /idTUdmin="U1917" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2225301..2225480) /gene="spoIIT" /locus_tag="BSU_24660" /old_locus_tag="BSU24660" /function="16.1: Circulate" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 26735940; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="factor involved in sporulation" /protein_id="NP_390346.2" /db_xref="EnsemblGenomes-Gn:BSU24660" /db_xref="EnsemblGenomes-Tr:CAB14397" /db_xref="InterPro:IPR025622" /db_xref="SubtiList:BG13771" /db_xref="UniProtKB/Swiss-Prot:O32020" /translation="MKTNDYVKYMTQQFVKYIDTPRDERKERKEVRKETKTPVSQQWF GILPYGFRLWLKRKK*" /label="spoIIT CDS" gene complement(2225301..2225480) /gene="spoIIT" /locus_tag="BSU_24660" /old_locus_tag="BSU24660" /label="spoIIT gene" promotor_-10 complement(2225499..2225517) /Source="Nicolas_upshift_promotors" /id="U1918" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.549450549450549" /psig="0.549450549450549" /xcortree=1011 /SigmaFactorBS="aaactgctgagatggacagaataaaacagtgtaaagGGTATA AaaaaagtcatgtgaGACAACACTCATAATAATTgaatgatgaggtgatcacgtgaaa a" /listShort="yqzE, S925" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2225514) /Source="Nicolas_upshifts" /id="U1918" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.549450549450549" /psig="0.549450549450549" /xcortree=1011 /SigmaFactorBS="aaactgctgagatggacagaataaaacagtgtaaagGGTATA AaaaaagtcatgtgaGACAACACTCATAATAATTgaatgatgaggtgatcacgtgaaa a" /listShort="yqzE, S925" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2225532..2225538) /Source="Nicolas_upshift_promotors" /id="U1918" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.549450549450549" /psig="0.549450549450549" /xcortree=1011 /SigmaFactorBS="aaactgctgagatggacagaataaaacagtgtaaagGGTATA AaaaaagtcatgtgaGACAACACTCATAATAATTgaatgatgaggtgatcacgtgaaa a" /listShort="yqzE, S925" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2225551..2225925) /gene="comGG" /locus_tag="BSU_24670" /old_locus_tag="BSU24670" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9150204, 9723928, 15849754, 16850406, 24164455" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9150204, 9723928, 15849754, 16850406, 24164455; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the DNA transport pilin platform" /protein_id="NP_390347.1" /db_xref="EnsemblGenomes-Gn:BSU24670" /db_xref="EnsemblGenomes-Tr:CAB14398" /db_xref="GOA:P25959" /db_xref="InterPro:IPR020372" /db_xref="SubtiList:BG10489" /db_xref="UniProtKB/Swiss-Prot:P25959" /translation="MYRTRGFIYPAVLFVSALVLLIVNFVAAQYISRCMFEKETKELY IGENLLQNGVLLSIRHVLEERKGQEGTQQFLYGRVSYYIHDTSIKEQKEINLRVSTDS GTERTAQIVFDQKQKKLLRWTE*" /label="comGG CDS" gene complement(2225551..2225925) /gene="comGG" /locus_tag="BSU_24670" /old_locus_tag="BSU24670" /label="comGG gene" CDS complement(2225926..2226309) /gene="comGF" /locus_tag="BSU_24680" /old_locus_tag="BSU24680" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9150204, 9723928, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9150204, 9723928, 15849754, 16850406; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the DNA transport pilin platform" /protein_id="NP_390348.1" /db_xref="EnsemblGenomes-Gn:BSU24680" /db_xref="EnsemblGenomes-Tr:CAB14399" /db_xref="GOA:P25958" /db_xref="InterPro:IPR016977" /db_xref="SubtiList:BG10488" /db_xref="UniProtKB/Swiss-Prot:P25958" /translation="MLISGSLAAIIHLFLSRQQEHDGFTQQEWMISIEQMMNECKESQ AVKTAEHGSVLICTNLSGQDIRFDIYHSMIRKRVDGKGHVPILDHITAMKADIENGVV LLKIESEDQKVYQTAFPVYSYLGGG*" /label="comGF CDS" gene complement(2225926..2226309) /gene="comGF" /locus_tag="BSU_24680" /old_locus_tag="BSU24680" /label="comGF gene" CDS complement(2226335..2226682) /gene="comGE" /locus_tag="BSU_24690" /old_locus_tag="BSU24690" /function="16.11: Scavenge (Catabolism)" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:7783624, 9224890, 9422590, 9723928, 16751195" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7783624, 9224890, 9422590, 9723928, 16751195; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the DNA transport pilin platform" /protein_id="NP_390349.1" /db_xref="EnsemblGenomes-Gn:BSU24690" /db_xref="EnsemblGenomes-Tr:CAB14400" /db_xref="GOA:P25957" /db_xref="InterPro:IPR012902" /db_xref="InterPro:IPR020488" /db_xref="SubtiList:BG10487" /db_xref="UniProtKB/Swiss-Prot:P25957" /translation="MWRENKGFSTIETMSALSLWLFVLLTVVPLWDKLMADEKMAESR EIGYQMMNESISKYVMSGEGAASKTITKNNHIYAMKWEEEGEYQNVCIKAAAYKEKSF CLSILQTEWLHAS*" /label="comGE CDS" gene complement(2226335..2226682) /gene="comGE" /locus_tag="BSU_24690" /old_locus_tag="BSU24690" /label="comGE gene" CDS complement(2226666..2227097) /gene="comGD" /locus_tag="BSU_24700" /old_locus_tag="BSU24700" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9224890, 9422590, 9723928, 16751195" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9224890, 9422590, 9723928, 16751195; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="membrane component of the DNA transport pilin platform" /protein_id="NP_390350.1" /db_xref="EnsemblGenomes-Gn:BSU24700" /db_xref="EnsemblGenomes-Tr:CAB14401" /db_xref="GOA:P25956" /db_xref="InterPro:IPR002416" /db_xref="InterPro:IPR012902" /db_xref="InterPro:IPR016785" /db_xref="SubtiList:BG10486" /db_xref="UniProtKB/Swiss-Prot:P25956" /translation="MNIKLNEEKGFTLLESLLVLSLASILLVAVFTTLPPAYDNTAVR QAASQLKNDIMLTQQTAISRQQRTKILFHKKEYQLVIGDTVIERPYATGLSIELLTLK DRLEFNEKGHPNAGGKIRVKGHAVYDITVYLGSGRVNVERK*" /label="comGD CDS" gene complement(2226666..2227097) /gene="comGD" /locus_tag="BSU_24700" /old_locus_tag="BSU24700" /label="comGD gene" CDS complement(2227087..2227383) /gene="comGC" /locus_tag="BSU_24710" /old_locus_tag="BSU24710" /function="16.11: Scavenge (Catabolism)" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:7783624, 9723928, 11744713, 16751195, 22820325, 24164455, 28659339" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7783624, 9723928, 11744713, 16751195, 22820325, 24164455, 28659339; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="pilin-like component of the DNA transport membrane pilin platform" /protein_id="NP_390351.1" /db_xref="EnsemblGenomes-Gn:BSU24710" /db_xref="EnsemblGenomes-Tr:CAB14402" /db_xref="GOA:P25955" /db_xref="InterPro:IPR012902" /db_xref="InterPro:IPR016940" /db_xref="SubtiList:BG10485" /db_xref="UniProtKB/Swiss-Prot:P25955" /translation="MNEKGFTLVEMLIVLFIISILLLITIPNVTKHNQTIQKKGCEGL QNMVKAQMTAFELDHEGQTPSLADLQSEGYVKKDAVCPNGKRIIITGGEVKVEH*" /label="comGC CDS" gene complement(2227087..2227383) /gene="comGC" /locus_tag="BSU_24710" /old_locus_tag="BSU24710" /label="comGC gene" CDS complement(2227397..2228368) /gene="comGB" /locus_tag="BSU_24720" /old_locus_tag="BSU24720" /function="16.11: Scavenge (Catabolism)" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9150204, 9723928, 15849754, 15968048, 16850406, 24164455" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9150204, 9723928, 15849754, 15968048, 16850406, 24164455; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="membrane pilin platform component of the DNA transport machinery" /protein_id="NP_390352.1" /db_xref="EnsemblGenomes-Gn:BSU24720" /db_xref="EnsemblGenomes-Tr:CAB14403" /db_xref="GOA:P25954" /db_xref="InterPro:IPR001992" /db_xref="InterPro:IPR018076" /db_xref="SubtiList:BG10484" /db_xref="UniProtKB/Swiss-Prot:P25954" /translation="MTAGGYTLLDGLRLMELQMNKRQAADLTDSVTCLREGAPFYQVL KSLSFHKEAVGICYFAETHGELPASMIQSGELLERKIAQADQLKRVLRYPLFLIFTVA VMFYMLQSIIIPQFSGIYQSMNMETSRSTDMLFAFFQHIDLVIILLVLFTAGIGIYYW LVFKKKSPARQMLICIRIPLVGKLVKLFNSYFFSLQLSSLLKSGLSIYDSLNAFKHQT FLPFYRCEAEQLIERLKAGESIESAICGSLFYETDLSKVISHGQLSGRLDRELFTYSQ FILQRLEHKAQKWTGILQPMIYGFVAAMILLVYLSMLVPMYQMMNQM*" /label="comGB CDS" gene complement(2227397..2228368) /gene="comGB" /locus_tag="BSU_24720" /old_locus_tag="BSU24720" /label="comGB gene" CDS complement(2228421..2229491) /gene="comGA" /locus_tag="BSU_24730" /old_locus_tag="BSU24730" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11298275, 15528548, 16009134, 9723928, 21564336, 21707789, 25899641" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11298275, 15528548, 16009134, 9723928, 21564336, 21707789, 25899641; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="membrane associated ATPase of the pilin platformfor DNA competence" /protein_id="NP_390353.1" /db_xref="EnsemblGenomes-Gn:BSU24730" /db_xref="EnsemblGenomes-Tr:CAB14404" /db_xref="GOA:P25953" /db_xref="InterPro:IPR001482" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10483" /db_xref="UniProtKB/Swiss-Prot:P25953" /translation="MDSIEKVSKNLIEEAYLTKASDIHIVPRERDAIIHFRVDHALLK KRDMKKEECVRLISHFKFLSAMDIGERRKPQNGSLTLKLKEGNVHLRMSTLPTINEES LVIRVMPQYNIPSIDKLSLFPKTGATLLSFLKHSHGMLIFTGPTGSGKTTTLYSLVQY AKKHFNRNIVTLEDPVETRDEDVLQVQVNEKAGVTYSAGLKAILRHDPDMIILGEIRD AETAEIAVRAAMTGHLVLTSLHTRDAKGAIYRLLEFGINMNEIEQTVIAIAAQRLVDL ACPFCENGCSSVYCRQSRNTRRASVYELLYGKNLQQCIQEAKGNHANYQYQTLRQIIR KGIALGYLTTNNYDRWVYHEKD*" /label="comGA CDS" gene complement(2228421..2229491) /gene="comGA" /locus_tag="BSU_24730" /old_locus_tag="BSU24730" /label="comGA gene" promotor_-10 complement(2229509..2229528) /Source="Nicolas_upshift_promotors" /id="U1919" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2966 /SigmaFactorBS="ttcagcatataacatctcacaaaatcacgttttcccTGTTTG ATtaccttttcttctTTTTCTACAATATGCGTTGAaaggagagggaatcaaattggat t" /listShort="comGA, comGB, comGC, comGD, comGE, comGF, comGG, yqzE, S925" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2229525) /Source="Nicolas_upshifts" /id="U1919" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2966 /SigmaFactorBS="ttcagcatataacatctcacaaaatcacgttttcccTGTTTG ATtaccttttcttctTTTTCTACAATATGCGTTGAaaggagagggaatcaaattggat t" /listShort="comGA, comGB, comGC, comGD, comGE, comGF, comGG, yqzE, S925" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2229542..2229549) /Source="Nicolas_upshift_promotors" /id="U1919" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2966 /SigmaFactorBS="ttcagcatataacatctcacaaaatcacgttttcccTGTTTG ATtaccttttcttctTTTTCTACAATATGCGTTGAaaggagagggaatcaaattggat t" /listShort="comGA, comGB, comGC, comGD, comGE, comGF, comGG, yqzE, S925" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2229674..2229902) /Source="Nicolas_S_feature" /locus_tag="new_2560260_2560488_c" /HighExp="Etha, Salt, Sw, Gly, LPhT, B36, Heat, B60, LoTm, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.37350499999999998" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S926" downshifts complement(2229715) /Source="Nicolas_upshifts" /id="D1283" /incds=0 /nref=16 /ntot=42 /MaxReadThrough="0.95925" /MaxDrop="5.92871" /score="30.7083619" /energy="-13" /TU="NA" /idTUdmin="U1920" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(2229903..2230856) /gene="yqxL" /locus_tag="BSU_24740" /old_locus_tag="BSU24740" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15856219, 24415722" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15856219, 24415722; Product type t: transporter" /codon_start=1 /transl_table=11 /product="CorA-type divalent ion transporter" /protein_id="NP_390354.1" /db_xref="EnsemblGenomes-Gn:BSU24740" /db_xref="EnsemblGenomes-Tr:CAB14405" /db_xref="GOA:P40948" /db_xref="InterPro:IPR002523" /db_xref="SubtiList:BG11075" /db_xref="UniProtKB/Swiss-Prot:P40948" /translation="MKAHTGKDWFWYQMGPQERSKARDLIHFSHWPQCEKWFENNHHV NFLRVDTTETENEAVFGSIVYDQGLGEEKDHTVFHFYITRQYFFTINFDFSILREIKG KEVVRQMERADNAIEGFLILLGELMNAYLIGVDEFEVKLRKLRWQIKDDNSKSILNRV HLLRHELMIWKNLILSAKKIEMALKETFLPQNEGKKDYQRTQLKIDRGFTYISEFEGE LNNLLHSEEVITSHRGNEIVKALTIFTTLFTPITALGALWGMNFSVMPELNWKYGYLF SLLLIVTSTVLIYLYLRKKGWTGDMLQERKKKKKPRKRRTL*" /label="yqxL CDS" gene complement(2229903..2230856) /gene="yqxL" /locus_tag="BSU_24740" /old_locus_tag="BSU24740" /label="yqxL gene" promotor_-10 complement(2230880..2230899) /Source="Nicolas_upshift_promotors" /id="U1920" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=239 /SigmaFactorBS="cacctgaaaatgctcataaaacatgtgttgaagcggcagact GGTTTAGtgacgcggttattGGGCAATTAAAGAATAAAGAacaaaagtttggaggagc t" /listShort="yqxL, S926" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2230901) /Source="Nicolas_upshifts" /id="U1920" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=239 /SigmaFactorBS="cacctgaaaatgctcataaaacatgtgttgaagcggcagact GGTTTAGtgacgcggttattGGGCAATTAAAGAATAAAGAacaaaagtttggaggagc t" /listShort="yqxL, S926" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2230913..2230919) /Source="Nicolas_upshift_promotors" /id="U1920" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=239 /SigmaFactorBS="cacctgaaaatgctcataaaacatgtgttgaagcggcagact GGTTTAGtgacgcggttattGGGCAATTAAAGAATAAAGAacaaaagtttggaggagc t" /listShort="yqxL, S926" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2230939..2230945 /Source="Nicolas_upshift_promotors" /id="U1921" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=246 /SigmaFactorBS="ccagtctgccgcttcaacacaTGTTTTAtgagcattttcagg TGGTATGGAATGTAGAAAGacatcggaaaagggaggtgcatgccttccttggagaagg c" /listShort="yqhB, S927" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2230960..2230978 /Source="Nicolas_upshift_promotors" /id="U1921" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=246 /SigmaFactorBS="ccagtctgccgcttcaacacaTGTTTTAtgagcattttcagg TGGTATGGAATGTAGAAAGacatcggaaaagggaggtgcatgccttccttggagaagg c" /listShort="yqhB, S927" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2230978 /Source="Nicolas_upshifts" /id="U1921" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=246 /SigmaFactorBS="ccagtctgccgcttcaacacaTGTTTTAtgagcattttcagg TGGTATGGAATGTAGAAAGacatcggaaaagggaggtgcatgccttccttggagaagg c" /listShort="yqhB, S927" /GFF_Attribute="listLong" /label="upshifts" CDS 2230999..2232327 /gene="yqhB" /locus_tag="BSU_24750" /old_locus_tag="BSU24750" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane associated enzyme" /protein_id="NP_390355.1" /db_xref="EnsemblGenomes-Gn:BSU24750" /db_xref="EnsemblGenomes-Tr:CAB14406" /db_xref="GOA:P54505" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR002550" /db_xref="InterPro:IPR005170" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG11695" /db_xref="UniProtKB/Swiss-Prot:P54505" /translation="MPSLEKAVVLEFINLLAVAILILLTGFFVAVEFSIVKVRRSKID QLVAKGKKGAKAAKHVITHLDEYLSACQLGITVAALGLGWLGEPTVQTLLRPLFHKAG LNESLTHLLSLVIAFLVVTYLNVVIGELAPKSFAIQKAESITLLFAKPLIWFYKIMFP FIWLLNHSARLITGVFGLKPASEHELAYTEEELRVLLAESYKSGEIRKSELKYMNNIF TFDKRMAKEIMVPRNEMVSLSLDEDSISNLQETVKQTKYTRYPVVREDKDNVIGVINM KEVLFSMLTKDFSIKKHQIEPFVQPVIHVIETIPIYKLLLKMQKERTHMAILIDEYGG TSGLVTVEDIIEEIVGEIRDEFDADEVPHIRELGKDHYLLNAKLLISDVNSLLGTDLS EAEVDTLGGWFLTQNIDAEPESAIEYDGYSFKVKDINSHHILFIEVKKAE*" /label="yqhB CDS" gene 2230999..2232327 /gene="yqhB" /locus_tag="BSU_24750" /old_locus_tag="BSU24750" /label="yqhB gene" S_feature 2232328..2233302 /Source="Nicolas_S_feature" /locus_tag="new_2562914_2563888" /HighExp="Sw, Salt, Etha, LPhT, M9-stat, S8, BC, S6, BT, Gly" /AntisenseName="rsbRD" /AntisenseCor="0.58358076577781004" /AntisenseRegPval="-25.2" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S927" CDS complement(2232380..2233216) /gene="rsbRD" /locus_tag="BSU_24760" /old_locus_tag="BSU24760" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11157946, 15312768, 15583165, 16963570, 17158665" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11157946, 15312768, 15583165, 16963570, 17158665; Product type f: factor" /codon_start=1 /transl_table=11 /product="component of the anxiosome (stressosome)" /protein_id="NP_390356.2" /db_xref="EnsemblGenomes-Gn:BSU24760" /db_xref="EnsemblGenomes-Tr:CAB14407" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR025751" /db_xref="InterPro:IPR036513" /db_xref="SubtiList:BG11694" /db_xref="UniProtKB/Swiss-Prot:P54504" /translation="MIALDQHLTEHKKDITQQWLEVCTSNGSWLYSAKDQQKLEQKLK DQHELLVTIVAKSLRKEDVEDELNRWSLQCARDRAVHEVTVTQSVGQFNTFRHIMFEW IHKFSEASSQDISIQEFYEWSRILNQNIDEIIEVFTEEYHQVTMIQLNAQKEMINELS APIMPITDGIGILPLVGEIDTHRARTILESVLEQCSALKLSYLFLDISGVPIVDTMVA YQIFKVIDSTKLLGIETIISGIRPEIAQTVVKLGLDFSNVKTEQSLAKALANKGFKIK EC*" /label="rsbRD CDS" gene complement(2232380..2233216) /gene="rsbRD" /locus_tag="BSU_24760" /old_locus_tag="BSU24760" /label="rsbRD gene" S_feature complement(2233217..2233401) /Source="Nicolas_S_feature" /locus_tag="new_2563803_2563987_c" /HighExp="Etha, LoTm, Salt, Heat, Gly, M9-stat, B60, S8, S0, Mal" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.147982" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S928" tRNA 2233303..2233373 /gene="trnSL-Gln1" /locus_tag="BSU_tRNA_73" /product="tRNA-Gln" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gln (UUG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /label="trnSL-Gln1 tRNA" gene 2233303..2233373 /gene="trnSL-Gln1" /locus_tag="BSU_tRNA_73" /label="trnSL-Gln1 gene" CDS complement(2233440..2233820) /gene="mgsR" /locus_tag="BSU_24770" /old_locus_tag="BSU24770" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:18643936, 22812682" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18643936, 22812682; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of stress" /protein_id="NP_390357.2" /db_xref="EnsemblGenomes-Gn:BSU24770" /db_xref="EnsemblGenomes-Tr:CAB14408" /db_xref="GOA:P54503" /db_xref="InterPro:IPR006504" /db_xref="InterPro:IPR006660" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG11693" /db_xref="UniProtKB/Swiss-Prot:P54503" /translation="MEQQLTFYSYPSCTSCRKTKHWLKAHQIEFNERHLFRETPTREE LKYILSLTTEGIDEILATRSQTFKNLNLNIEEMTVNEVLELLIEKPKLLRRPILVDNK KLVIGYNPGELLKLSKKKTVHQSA*" /label="mgsR CDS" gene complement(2233440..2233820) /gene="mgsR" /locus_tag="BSU_24770" /old_locus_tag="BSU24770" /label="mgsR gene" downshifts complement(2233446) /Source="Nicolas_upshifts" /id="D1284" /incds=0 /nref=9 /ntot=174 /MaxReadThrough="6.12556" /MaxDrop="6.72616" /score="0.164931099" /energy="-19.7" /TU="U1922" /idTUdmin="U1925" /TUdmin=912 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2233849..2233867) /Source="Nicolas_upshift_promotors" /id="U1922" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=225 /SigmaFactorBS="aatgttttttaaaaaataatccgaaaaaagttctgtaaatGG TTTAAatgaaaaatgatccGGGTAGTTATTCTACAAAGagatggttaactgaggagga a" /listShort="mgsR, S928, rsbRD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2233868) /Source="Nicolas_upshifts" /id="U1922" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=225 /SigmaFactorBS="aatgttttttaaaaaataatccgaaaaaagttctgtaaatGG TTTAAatgaaaaatgatccGGGTAGTTATTCTACAAAGagatggttaactgaggagga a" /listShort="mgsR, S928, rsbRD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2233882..2233888) /Source="Nicolas_upshift_promotors" /id="U1922" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=225 /SigmaFactorBS="aatgttttttaaaaaataatccgaaaaaagttctgtaaatGG TTTAAatgaaaaatgatccGGGTAGTTATTCTACAAAGagatggttaactgaggagga a" /listShort="mgsR, S928, rsbRD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2233907..2233912 /Source="Nicolas_upshift_promotors" /id="U1923" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1002 /SigmaFactorBS="ttcatttaaaccatttacagaacttttttcGGATTAtttttt aaaaaacatTCATACAATAGAAAACACAatcaaagggacaaattccatttgtatatta a" /GFF_Attribute="listShort" /listLong="yqgY, S929, yqgW, S930" /label="promotor_-35" promotor_-10 2233928..2233946 /Source="Nicolas_upshift_promotors" /id="U1923" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1002 /SigmaFactorBS="ttcatttaaaccatttacagaacttttttcGGATTAtttttt aaaaaacatTCATACAATAGAAAACACAatcaaagggacaaattccatttgtatatta a" /GFF_Attribute="listShort" /listLong="yqgY, S929, yqgW, S930" /label="promotor_-10" upshifts 2233937 /Source="Nicolas_upshifts" /id="U1923" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1002 /SigmaFactorBS="ttcatttaaaccatttacagaacttttttcGGATTAtttttt aaaaaacatTCATACAATAGAAAACACAatcaaagggacaaattccatttgtatatta a" /GFF_Attribute="listShort" /listLong="yqgY, S929, yqgW, S930" /label="upshifts" promotor_-35 2233987..2233994 /Source="Nicolas_upshift_promotors" /id="U1924" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=513 /SigmaFactorBS="caaagggacaaattccatttgtatattaataatgaaaaTGTT TACAtttctaggtgtgatcTATTATAATAACAGTCAGAGggactctcgggaggggata a" /listShort="yqgY, S929" /listLong="yqgW, S930" /label="promotor_-35" upshifts 2234009 /Source="Nicolas_upshifts" /id="U1924" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=513 /SigmaFactorBS="caaagggacaaattccatttgtatattaataatgaaaaTGTT TACAtttctaggtgtgatcTATTATAATAACAGTCAGAGggactctcgggaggggata a" /listShort="yqgY, S929" /listLong="yqgW, S930" /label="upshifts" promotor_-10 2234010..2234029 /Source="Nicolas_upshift_promotors" /id="U1924" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=513 /SigmaFactorBS="caaagggacaaattccatttgtatattaataatgaaaaTGTT TACAtttctaggtgtgatcTATTATAATAACAGTCAGAGggactctcgggaggggata a" /listShort="yqgY, S929" /listLong="yqgW, S930" /label="promotor_-10" CDS 2234052..2234297 /gene="yqgY" /locus_tag="BSU_24780" /old_locus_tag="BSU24780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390358.1" /db_xref="EnsemblGenomes-Gn:BSU24780" /db_xref="EnsemblGenomes-Tr:CAB14409" /db_xref="GOA:P54502" /db_xref="InterPro:IPR020254" /db_xref="SubtiList:BG11692" /db_xref="UniProtKB/Swiss-Prot:P54502" /translation="MNRMFRVLGFWTGIFAVMFYLGDMKDASLLFFGQTILFVFLSYL NLTERMYIYIFGAYLTIFFAGFTYYSIFIMVPGGGGH*" /label="yqgY CDS" gene 2234052..2234297 /gene="yqgY" /locus_tag="BSU_24780" /old_locus_tag="BSU24780" /label="yqgY gene" downshifts 2234194 /Source="Nicolas_upshifts" /id="D1285" /incds=1 /nref=1 /ntot=86 /MaxReadThrough="6.68961" /MaxDrop="2.1025" /score="22.3415753" /energy="-13.7" /TU="U1924" /idTUdmin="U1923" /TUdmin=176 /isTUend="FALSE" /label="downshifts" downshifts 2234283 /Source="Nicolas_upshifts" /id="D1286" /incds=0 /nref=98 /ntot=234 /MaxReadThrough="4.03872" /MaxDrop="5.76938" /score="22.3415753" /energy="-13.7" /TU="U1924" /idTUdmin="U1923" /TUdmin=265 /isTUend="FALSE" /label="downshifts" S_feature 2234328..2235083 /Source="Nicolas_S_feature" /locus_tag="new_2564914_2565669" /HighExp="M9-stat, T0.30H, T1.30H, LoTm, T1.0H, B60, T2.0H, S5, S4, T2.30H" /AntisenseName="yqgX" /AntisenseCor="-0.68109878166952498" /AntisenseRegPval="-37.299999999999997" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig=1 /label="S929" CDS complement(2234337..2234972) /gene="yqgX" /locus_tag="BSU_24790" /old_locus_tag="BSU24790" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20669241, 22333191; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-binding hydrolase" /protein_id="NP_390359.1" /db_xref="EnsemblGenomes-Gn:BSU24790" /db_xref="EnsemblGenomes-Tr:CAB14410" /db_xref="GOA:P54501" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG11691" /db_xref="UniProtKB/Swiss-Prot:P54501" /translation="MKWRRMPVGPIQANAYFLISDDQCLIFDPGGEGHKINQYIKEKG LTPLAILLTHAHFDHIGALDEVREKWDIPVYLHQNEKNWLADASLNGSGMLRGIEVTA KPADHLIEGDGELNIGPFHLETLFTPGHSPGSVSYYVKDADLVISGDVLFQGGIGRTD LIGGNQETLLTSIHEKLLTLPEHTLVLSGHGPETDVLTEQDQNPFLNGFSL*" /label="yqgX CDS" gene complement(2234337..2234972) /gene="yqgX" /locus_tag="BSU_24790" /old_locus_tag="BSU24790" /label="yqgX gene" downshifts complement(2234362) /Source="Nicolas_upshifts" /id="D1287" /incds=0 /nref=154 /ntot=239 /MaxReadThrough="1.42757" /MaxDrop="5.15622" /score="-8.36666809" /energy="-13.7" /TU="NA" /idTUdmin="U1925" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2234994..2235013) /Source="Nicolas_upshift_promotors" /id="U1925" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=2361 /SigmaFactorBS="ttttttataggtttgtcgatagcgttttcattgcgatTGTTT GAAtcttttttcaaaaACCCTCATAATAAGAGCATAaaaaagaaagaggtgataatag t" /listShort="yqgX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2235011) /Source="Nicolas_upshifts" /id="U1925" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=2361 /SigmaFactorBS="ttttttataggtttgtcgatagcgttttcattgcgatTGTTT GAAtcttttttcaaaaACCCTCATAATAAGAGCATAaaaaagaaagaggtgataatag t" /listShort="yqgX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2235027..2235034) /Source="Nicolas_upshift_promotors" /id="U1925" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=2361 /SigmaFactorBS="ttttttataggtttgtcgatagcgttttcattgcgatTGTTT GAAtcttttttcaaaaACCCTCATAATAAGAGCATAaaaaagaaagaggtgataatag t" /listShort="yqgX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2235051..2235058 /Source="Nicolas_upshift_promotors" /id="U1926" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=514 /SigmaFactorBS="gattcaaacaatcgcaatgaaaacgcTATCGACAaacctata aaaaacAGGTAGAATAAAACTGGAAAgaattgcaggtttttcaatgtaaagggggctg t" /listShort="yqgW, S930" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2235073..2235092 /Source="Nicolas_upshift_promotors" /id="U1926" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=514 /SigmaFactorBS="gattcaaacaatcgcaatgaaaacgcTATCGACAaacctata aaaaacAGGTAGAATAAAACTGGAAAgaattgcaggtttttcaatgtaaagggggctg t" /listShort="yqgW, S930" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2235085 /Source="Nicolas_upshifts" /id="U1926" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=514 /SigmaFactorBS="gattcaaacaatcgcaatgaaaacgcTATCGACAaacctata aaaaacAGGTAGAATAAAACTGGAAAgaattgcaggtttttcaatgtaaagggggctg t" /listShort="yqgW, S930" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2235105) /Source="Nicolas_upshifts" /id="U1927" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.996003996003996" /psig=0 /xcortree=709 /SigmaFactorBS="aaagagcgacaaggccgaaaatcacgacaagtAACATaacac agCCCCCTTTACATTGAaaaacctgcaattctttccagttttattctacctgtttttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2235107..2235121) /Source="Nicolas_upshift_promotors" /id="U1927" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.996003996003996" /psig=0 /xcortree=709 /SigmaFactorBS="aaagagcgacaaggccgaaaatcacgacaagtAACATaacac agCCCCCTTTACATTGAaaaacctgcaattctttccagttttattctacctgtttttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2235129..2235133) /Source="Nicolas_upshift_promotors" /id="U1927" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.996003996003996" /psig=0 /xcortree=709 /SigmaFactorBS="aaagagcgacaaggccgaaaatcacgacaagtAACATaacac agCCCCCTTTACATTGAaaaacctgcaattctttccagttttattctacctgtttttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2235129..2235302 /gene="yqgW" /locus_tag="BSU_24800" /old_locus_tag="BSU24800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390360.1" /db_xref="EnsemblGenomes-Gn:BSU24800" /db_xref="EnsemblGenomes-Tr:CAB14411" /db_xref="GOA:P54500" /db_xref="InterPro:IPR024490" /db_xref="SubtiList:BG11690" /db_xref="UniProtKB/Swiss-Prot:P54500" /translation="MLLVVIFGLVALFALWGVLRSVRNKNILGFLLAGATLFVFGWFT VMTVINSGYPTAH*" /label="yqgW CDS" gene 2235129..2235302 /gene="yqgW" /locus_tag="BSU_24800" /old_locus_tag="BSU24800" /label="yqgW gene" downshifts 2235290 /Source="Nicolas_upshifts" /id="D1288" /incds=0 /nref=255 /ntot=278 /MaxReadThrough="3.92092" /MaxDrop="7.18555" /score="14.1643615" /energy="-12.4" /TU="U1926" /idTUdmin="U1924" /TUdmin=217 /isTUend="FALSE" /label="downshifts" CDS complement(2235334..2235648) /gene="yqgV" /locus_tag="BSU_24810" /old_locus_tag="BSU24810" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390361.2" /db_xref="EnsemblGenomes-Gn:BSU24810" /db_xref="EnsemblGenomes-Tr:CAB14412" /db_xref="GOA:P54499" /db_xref="InterPro:IPR002767" /db_xref="InterPro:IPR029756" /db_xref="SubtiList:BG11689" /db_xref="UniProtKB/Swiss-Prot:P54499" /translation="MAIADVTIIPIGTETPSVSAYVADVQKILEGYQAEGKIKYQLTP MNTLIEGELSDLFAVIQAIHEAPFQKGLHRVATNIRIDDRRDKKTTLESKIESVNKHL QP*" /label="yqgV CDS" gene complement(2235334..2235648) /gene="yqgV" /locus_tag="BSU_24810" /old_locus_tag="BSU24810" /label="yqgV gene" S_feature 2235335..2236402 /Source="Nicolas_S_feature" /locus_tag="new_2565921_2566988" /HighExp="LoTm, M9-stat, C30, Cold, S8, S7, B60, Lbstat, G135, C90" /AntisenseName="yqgV" /AntisenseCor="-0.23995763414552801" /AntisenseRegPval="-4.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigEF" /TUlongPSig="1, 1" /label="S930" downshifts complement(2235348) /Source="Nicolas_upshifts" /id="D1289" /incds=0 /nref=247 /ntot=265 /MaxReadThrough="2.24429" /MaxDrop="6.85096" /score="0.185625845" /energy="-12.4" /TU="NA" /idTUdmin="U1928" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2235651..2236712) /gene="yqgU" /locus_tag="BSU_24820" /old_locus_tag="BSU24820" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_390362.2" /db_xref="EnsemblGenomes-Gn:BSU24820" /db_xref="EnsemblGenomes-Tr:CAB14413" /db_xref="GOA:P54498" /db_xref="SubtiList:BG11688" /db_xref="UniProtKB/Swiss-Prot:P54498" /translation="MLMRSVCFILLAVLLFSLSACEPSHQQQKQASAAKDEKKDIIPL SAEKADGAEGWLNNSTILYTASNPTKTELFAYRIFTGKAKKLYQTDGQIVDVQINARE QMILLQITHSQKTAVVLLNAEGETLYEKDYETYELEAAWNQYDPYQMMVTEFNENWDF HTYQVNAKKDESFLSPVQVPFIHWTSKNTFDYVKEGRDDKTGPLYTFDTASKTEQKLE DNVLFFDSFHQMSFTVKSASGGKGTYQFKTPQSTSPVTAKWPLQAKYTSLAPMEYDYD EAGGLFYTFKQSGDAYKLAAINVASGETKDLVSLREMEPIQISPNGKYALYGFHFEQI ILLKSHETKQLIIDQKEME*" /label="yqgU CDS" gene complement(2235651..2236712) /gene="yqgU" /locus_tag="BSU_24820" /old_locus_tag="BSU24820" /label="yqgU gene" CDS complement(2236774..2237904) /gene="yqgT" /locus_tag="BSU_24830" /old_locus_tag="BSU24830" /function="16.13: Shape" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12765833, 24163346; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative d,l-endopeptidase" /protein_id="NP_390363.1" /db_xref="EnsemblGenomes-Gn:BSU24830" /db_xref="EnsemblGenomes-Tr:CAB14414" /db_xref="GOA:P54497" /db_xref="InterPro:IPR000834" /db_xref="InterPro:IPR034274" /db_xref="SubtiList:BG11687" /db_xref="UniProtKB/Swiss-Prot:P54497" /translation="MMAFITVKPEIKNNLANVAKELKIDEELLKSANRSAQKHQLYCP GYVIEEHSGKELQTIQDIKRFLQPRQLKLSDSWIEQEKIYDDSAVEKEIKKIIDVFPF VSCREIGRSVLGRPIWELKAGGEHAVKKVHMNASFHANEWITTSVLLKWFKEYCMSLC CNSPFFGFSPIKLFNSTSLSLVPLVNPDGVDLVLNGSEVMGARRDELERLNEHRPNFN EWKANINGVDLNKQFPSLWEIEKYRKPTAPSYRDFPGISPLTEPESIAMYRLITENPP DRLLALHTQGEEIYWGYKGLEPEESAAVIKEFEELSGNIYKGVRDIDSYAGFRDWFIH HYFKEGYTVELGKGQNPLPFQQFSHIYNATSGILWRALFFHE*" /label="yqgT CDS" gene complement(2236774..2237904) /gene="yqgT" /locus_tag="BSU_24830" /old_locus_tag="BSU24830" /label="yqgT gene" promotor_-10 complement(2237912..2237930) /Source="Nicolas_upshift_promotors" /id="U1928" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.927072927072927" /psig="0.927072927072927" /xcortree=1180 /SigmaFactorBS="cttgatcaggcatcataatcacaatgtctcccgcatcgaagt gagcgggaggcTTTCTTtttttaaatacgctgTCATATAGTAACAAAAAAGggggatg a" /listShort="yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2237944) /Source="Nicolas_upshifts" /id="U1928" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.927072927072927" /psig="0.927072927072927" /xcortree=1180 /SigmaFactorBS="cttgatcaggcatcataatcacaatgtctcccgcatcgaagt gagcgggaggcTTTCTTtttttaaatacgctgTCATATAGTAACAAAAAAGggggatg a" /listShort="yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2237946..2237951) /Source="Nicolas_upshift_promotors" /id="U1928" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.927072927072927" /psig="0.927072927072927" /xcortree=1180 /SigmaFactorBS="cttgatcaggcatcataatcacaatgtctcccgcatcgaagt gagcgggaggcTTTCTTtttttaaatacgctgTCATATAGTAACAAAAAAGggggatg a" /listShort="yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2237987..2239903) /gene="ltaSC" /locus_tag="BSU_24840" /old_locus_tag="BSU24840" /function="16.13: Shape" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15187182, 21255105, 23103977, 25288647, 25666134" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15187182, 21255105, 23103977, 25288647, 25666134; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enzyme responsible for polyglycerolphosphate LTAsynthesis" /protein_id="NP_390364.2" /db_xref="EnsemblGenomes-Gn:BSU24840" /db_xref="EnsemblGenomes-Tr:CAB14415" /db_xref="GOA:P54496" /db_xref="InterPro:IPR000917" /db_xref="InterPro:IPR012160" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="SubtiList:BG11686" /db_xref="UniProtKB/Swiss-Prot:P54496" /translation="MRKTFFSKISFMLIAILLMWLKTYAVYKTSFHIKIDNLTQEFIL FINPLSFLLLIFGLSLFLKGKNRNRYIIAMSCLVTFVLLANMVFYRFYNDFLTIPVLF QTSNMGDLGSSIGTLLEPTDLLLAVDIAVLIWLHIRQKAFQSDIPSTKNERAAYFLFV ASVYFFNLGLSEAERPQLLTRSFDREMLVKNISLFNFHIYDGVLQSKQSAQRALADSN SLTEIENYVTANAKDANKRLFGAAKGRNVILVSLESTQSFVINEKLNGEEITPFLNDF IKQSYNFNNVYHQTGQGKTSDSEFIVDNSLYPLGRGAVFFTNAGNQYMAAPEILKNSG YYSAVLHANNKSFWNRDLMYDSFGYDSFFDINSYDVTDENSVGWGLKDKEFFEQSSEL MKNLPQPFYSRLITLTNHFPFDLDEEDQLIDEYDSNSQTLNKYFPTVRYQDEALKRFI EKLKEDGLYDNSVIVLYGDHYGISENHNEAMGQFLGKEITPFEEVQLQKVPLVIHIPG ITDKKPQTIETVGGQIDIRPTLMNLLGIDTKDQIQFGNDLLSDEKLDFTVLRDGSFIT DQVVYTDGACYDKETGKPLEETKQCEAFADKAKQELSLSDEIIYGDLLRFYDQKRLDN SSKRKEKQMLDQAS*" /label="ltaSC CDS" gene complement(2237987..2239903) /gene="ltaSC" /locus_tag="BSU_24840" /old_locus_tag="BSU24840" /label="ltaSC gene" downshifts complement(2238014) /Source="Nicolas_upshifts" /id="D1290" /incds=0 /nref=5 /ntot=142 /MaxReadThrough="4.5611" /MaxDrop="3.8416" /score="15.4764643" /energy="-14.5" /TU="U1930,U1931" /idTUdmin="U1928" /TUdmin="-2667" /isTUend="FALSE" /label="downshifts" promotor_-35 2239019..2239025 /Source="Nicolas_upshift_promotors" /id="U1929" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=213 /SigmaFactorBS="agcggatacagtgaattgtccacgataaattcagaatccgaG GTTTTCccctggcctgtttggTGGTAAACATTATTAAAGTtgtagctctgttttataa a" /listShort="S931" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2239038..2240067 /Source="Nicolas_S_feature" /locus_tag="new_2569624_2570653" /HighExp="Etha, Gly, M9-stat, Salt, S8, LPhT, S7, Sw, HiTm, B60" /AntisenseName="yqgS" /AntisenseCor="-0.36996929809172002" /AntisenseRegPval="-9.4" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S931" upshifts 2239038 /Source="Nicolas_upshifts" /id="U1929" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=213 /SigmaFactorBS="agcggatacagtgaattgtccacgataaattcagaatccgaG GTTTTCccctggcctgtttggTGGTAAACATTATTAAAGTtgtagctctgttttataa a" /listShort="S931" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2239041..2239059 /Source="Nicolas_upshift_promotors" /id="U1929" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=213 /SigmaFactorBS="agcggatacagtgaattgtccacgataaattcagaatccgaG GTTTTCccctggcctgtttggTGGTAAACATTATTAAAGTtgtagctctgttttataa a" /listShort="S931" /GFF_Attribute="listLong" /label="promotor_-10" S_feature complement(2239904..2239970) /Source="Nicolas_S_feature" /locus_tag="new_2570490_2570556_c" /HighExp="T-3.40H, BC, Sw, S5, Lbstat, T-5.40H, S4, ferm, C30, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S932" promotor_-10 complement(2239964..2239983) /Source="Nicolas_upshift_promotors" /id="U1930" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.483516483516484" /psig=1 /xcortree=3130 /SigmaFactorBS="aaaattgttaaaattgtgtaaatgaAATTGATTttttgttgt gctcaGGTTAAGATTTAATTTGATGtgttaatgagaatgttgggaatagactgatttt t" /listShort="S932, yqgS, yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2239970) /Source="Nicolas_upshifts" /id="U1930" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.483516483516484" /psig=1 /xcortree=3130 /SigmaFactorBS="aaaattgttaaaattgtgtaaatgaAATTGATTttttgttgt gctcaGGTTAAGATTTAATTTGATGtgttaatgagaatgttgggaatagactgatttt t" /listShort="S932, yqgS, yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2239998..2240005) /Source="Nicolas_upshift_promotors" /id="U1930" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.483516483516484" /psig=1 /xcortree=3130 /SigmaFactorBS="aaaattgttaaaattgtgtaaatgaAATTGATTttttgttgt gctcaGGTTAAGATTTAATTTGATGtgttaatgagaatgttgggaatagactgatttt t" /listShort="S932, yqgS, yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2240020..2240985) /gene="glcK" /locus_tag="BSU_24850" /old_locus_tag="BSU24850" /EC_number="2.7.1.59" /EC_number="2.7.1.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9620975, 10737197, 15018644, 15050034, 20495944, 21108133, 27324299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9620975, 10737197, 15018644, 15050034, 20495944, 21108133, 27324299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucose kinase" /protein_id="NP_390365.2" /db_xref="EnsemblGenomes-Gn:BSU24850" /db_xref="EnsemblGenomes-Tr:CAB14416" /db_xref="GOA:P54495" /db_xref="InterPro:IPR000600" /db_xref="InterPro:IPR004654" /db_xref="SubtiList:BG11685" /db_xref="UniProtKB/Swiss-Prot:P54495" /translation="MDEIWFAGIDLGGTTIKLAFINQYGEIQHKWEVPTDKTGDTITV TIAKTIDSKLDELQKPKHIIKYIGMGAPGPVDMAAGVVYETVNLGWKNYALKNHLETE TGIPAVIENDANIAALGEMWKGAGDGAKDVILVTLGTGVGGGIIANGEIVHGINGAGG EIGHICSIPEGGAPCNCGKTGCIETIASATGIVRIAKEKIANAKKTTRLKATEQLSAR DVFEAAGENDEIALEVVDYVAKHLGLVLGNLASSLNPSKIVLGGGVSRAGELLRSKVE KTFRKCAFPRAAQAADISIAALGNDAGVIGGAWIAKNEWLKHQNC*" /label="glcK CDS" gene complement(2240020..2240985) /gene="glcK" /locus_tag="BSU_24850" /old_locus_tag="BSU24850" /label="glcK gene" CDS complement(2240996..2241211) /gene="yqgQ" /locus_tag="BSU_24860" /old_locus_tag="BSU24860" /function="9.3: Transcription factors" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15050034, 20057058; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative single strand nucleic acid binding transcription factor" /protein_id="NP_390366.1" /db_xref="EnsemblGenomes-Gn:BSU24860" /db_xref="EnsemblGenomes-Tr:CAB14417" /db_xref="InterPro:IPR009256" /db_xref="InterPro:IPR023164" /db_xref="PDB:2NN4" /db_xref="SubtiList:BG11684" /db_xref="UniProtKB/Swiss-Prot:P54494" /translation="MNTFYDVQQLLKTFGHIVYFGDRELEIEFMLDELKELYMNHMIE KEQWARAAAVLRKELEQTKNGRDFYKG*" /label="yqgQ CDS" gene complement(2240996..2241211) /gene="yqgQ" /locus_tag="BSU_24860" /old_locus_tag="BSU24860" /label="yqgQ gene" S_feature complement(2241212..2241320) /Source="Nicolas_S_feature" /locus_tag="new_2571798_2571906_c" /HighExp="M0t90, Lbstat, M40t90, M40t45, Lbtran, Mt0, dia5, Diami, M0t45, BI" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S933" CDS complement(2241321..2242844) /gene="glpG" /locus_tag="BSU_24870" /old_locus_tag="BSU24870" /EC_number="3.4.21.105" /function="16.1: Circulate" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15050034, 16355228, 23518036, 26858402; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="membrane endopeptidase" /protein_id="NP_390367.2" /db_xref="EnsemblGenomes-Gn:BSU24870" /db_xref="EnsemblGenomes-Tr:CAB14418" /db_xref="GOA:P54493" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="InterPro:IPR022764" /db_xref="InterPro:IPR035952" /db_xref="SubtiList:BG11683" /db_xref="UniProtKB/Swiss-Prot:P54493" /translation="MFLLEYTYWKIAAHLVNSGYGVIQAGESDEIWLEAPDKSSHDLV RLYKHDLDFRQEMVRDIEEQAERVERVRHQLGRRRMKLLNVFFSTEAPVDDWEEIAKK TFEKGTVSVEPAIVRGTMLRDDLQAVFPSFRTEDCSEEHASFENAQMARERFLSLVLK QEEQRKTEAAVFQNGKPTFTYLFIALQILMFFLLEINGGSTNTETLVAFGAKENSLIA QGEWWRLLTPIVLHIGIAHLAFNTLALWSVGTAVERMYGSGRFLLIYLAAGITGSIAS FVFSPYPSAGASGAIFGCLGALLYVALSNRKMFLRTIGTNIIVIIIINLGFGFAVSNI DNSGHIGGLIGGFFAAAALGLPKAGAFGKRLLSAVLLIALAVGFLYYGLHSPSHQESA LIQQASELYQEGKYEEVTELLNGEAAQKDASADLLKILAVSDIQIGEYDQAVSLLERA VKKEPKDHASYYNLALLYAEKNELAQAEKAIQTAVKLKPKEQRYKELQRQIENNKES* " /label="glpG CDS" gene complement(2241321..2242844) /gene="glpG" /locus_tag="BSU_24870" /old_locus_tag="BSU24870" /label="glpG gene" promotor_-10 complement(2242862..2242881) /Source="Nicolas_upshift_promotors" /id="U1931" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.602397602397602" /psig=1 /xcortree=2337 /SigmaFactorBS="aaaatcccgtgaaaaacgggattttttgctttCAGTAGGCgt ttcggagcgccaGCTGTTATAATGAAAAAAAActattggagcggtaaacatgtttttg c" /listShort="glpG, S933, yqgQ, glcK, S932, yqgS, yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2242875) /Source="Nicolas_upshifts" /id="U1931" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.602397602397602" /psig=1 /xcortree=2337 /SigmaFactorBS="aaaatcccgtgaaaaacgggattttttgctttCAGTAGGCgt ttcggagcgccaGCTGTTATAATGAAAAAAAActattggagcggtaaacatgtttttg c" /listShort="glpG, S933, yqgQ, glcK, S932, yqgS, yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2242896..2242903) /Source="Nicolas_upshift_promotors" /id="U1931" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.602397602397602" /psig=1 /xcortree=2337 /SigmaFactorBS="aaaatcccgtgaaaaacgggattttttgctttCAGTAGGCgt ttcggagcgccaGCTGTTATAATGAAAAAAAActattggagcggtaaacatgtttttg c" /listShort="glpG, S933, yqgQ, glcK, S932, yqgS, yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2242934..2243107) /gene="yqgO" /locus_tag="BSU_24880" /old_locus_tag="BSU24880" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390368.1" /db_xref="EnsemblGenomes-Gn:BSU24880" /db_xref="EnsemblGenomes-Tr:CAB14419" /db_xref="SubtiList:BG11682" /db_xref="UniProtKB/Swiss-Prot:P54492" /translation="MKKLLIYAIFAVSAVMFYQNRYRLMNTVLSQPGIRRSFIHLFLR IPFIRNKFIQQAF*" /label="yqgO CDS" gene complement(2242934..2243107) /gene="yqgO" /locus_tag="BSU_24880" /old_locus_tag="BSU24880" /label="yqgO gene" downshifts complement(2242961) /Source="Nicolas_upshifts" /id="D1291" /incds=0 /nref=121 /ntot=211 /MaxReadThrough="2.93694" /MaxDrop="5.6047" /score="19.2452946" /energy="-8.9" /TU="NA" /idTUdmin="U1932" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2243123..2243134) /Source="Nicolas_upshift_promotors" /id="U1932" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=909 /SigmaFactorBS="gattatttcttgtttttcataactttcctgtcccttattcgA GAATAAataaggtagaataACAAACCCTATTggcaggagggatatcatgaaaaaactt t" /listShort="yqgO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2243135) /Source="Nicolas_upshifts" /id="U1932" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=909 /SigmaFactorBS="gattatttcttgtttttcataactttcctgtcccttattcgA GAATAAataaggtagaataACAAACCCTATTggcaggagggatatcatgaaaaaactt t" /listShort="yqgO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2243148..2243154) /Source="Nicolas_upshift_promotors" /id="U1932" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=909 /SigmaFactorBS="gattatttcttgtttttcataactttcctgtcccttattcgA GAATAAataaggtagaataACAAACCCTATTggcaggagggatatcatgaaaaaactt t" /listShort="yqgO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2243174..2243737) /gene="folN" /locus_tag="BSU_24890" /old_locus_tag="BSU24890" /EC_number="6.3.3.2" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17329806, 20952389, 22773193; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-formyltetrahydrofolate cyclo-ligase" /protein_id="NP_390369.1" /db_xref="EnsemblGenomes-Gn:BSU24890" /db_xref="EnsemblGenomes-Tr:CAB14420" /db_xref="GOA:P54491" /db_xref="InterPro:IPR002698" /db_xref="PDB:1YDM" /db_xref="SubtiList:BG11681" /db_xref="UniProtKB/Swiss-Prot:P54491" /translation="MKSQLRKKTLEALSALSNEDILQKTERMYKYLFSLPEWQNAGTI AVTISRGLEIPTRPVIEQAWEEGKQVCIPKCHPDTKKMQFRTYQTDDQLETVYAGLLE PVIEKTKEVNPSQIDLMIVPGVCFDVNGFRVGFGGGYYDRYLSEYEGKTVSLLLECQL FAHVPRLPHDIPVHKLITEDRIISCFS*" /label="folN CDS" gene complement(2243174..2243737) /gene="folN" /locus_tag="BSU_24890" /old_locus_tag="BSU24890" /label="folN gene" S_feature complement(2243738..2243821) /Source="Nicolas_S_feature" /locus_tag="new_2574324_2574407_c" /HighExp="Cold, G180, LBGexp, LBGtran, G135, HPh, LPh, dia0, Oxctl, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S934" CDS complement(2243822..2243971) /gene="rpmGA" /locus_tag="BSU_24900" /old_locus_tag="BSU24900" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 12904577, 19648245, 22720735, 23002217, 27561249; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L33" /protein_id="NP_570908.2" /db_xref="EnsemblGenomes-Gn:BSU24900" /db_xref="EnsemblGenomes-Tr:CAE01461" /db_xref="GOA:P56849" /db_xref="InterPro:IPR001705" /db_xref="InterPro:IPR011332" /db_xref="InterPro:IPR018264" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG14180" /db_xref="UniProtKB/Swiss-Prot:P56849" /translation="MRVNITLACTECGERNYISKKNKRNNPDRVEFKKYCPRDKKSTL HRETK*" /label="rpmGA CDS" gene complement(2243822..2243971) /gene="rpmGA" /locus_tag="BSU_24900" /old_locus_tag="BSU24900" /label="rpmGA gene" downshifts complement(2243868) /Source="Nicolas_upshifts" /id="D1292" /incds=0 /nref=154 /ntot=253 /MaxReadThrough="5.3064" /MaxDrop="4.5881" /score="34.7393253" /energy="-15.3" /TU="U1933" /idTUdmin="U1932" /TUdmin="-907" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2244008..2244027) /Source="Nicolas_upshift_promotors" /id="U1933" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=2638 /SigmaFactorBS="ttcaataattcagcaattcattgaaaaacagcCTAGcattcc gtccattatAGTGGTATTATATATAAGTCtgaataagtaaatgattttagtttggagg g" /listShort="rpmGA, S934, yqgN, yqgO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2244018) /Source="Nicolas_upshifts" /id="U1933" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=2638 /SigmaFactorBS="ttcaataattcagcaattcattgaaaaacagcCTAGcattcc gtccattatAGTGGTATTATATATAAGTCtgaataagtaaatgattttagtttggagg g" /listShort="rpmGA, S934, yqgN, yqgO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2244043..2244046) /Source="Nicolas_upshift_promotors" /id="U1933" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=2638 /SigmaFactorBS="ttcaataattcagcaattcattgaaaaacagcCTAGcattcc gtccattatAGTGGTATTATATATAAGTCtgaataagtaaatgattttagtttggagg g" /listShort="rpmGA, S934, yqgN, yqgO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2244055..2245134) /gene="yqgM" /locus_tag="BSU_24910" /old_locus_tag="BSU24910" /EC_number="2.4.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_390370.2" /db_xref="EnsemblGenomes-Gn:BSU24910" /db_xref="EnsemblGenomes-Tr:CAB14421" /db_xref="GOA:P54490" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR028098" /db_xref="SubtiList:BG11680" /db_xref="UniProtKB/Swiss-Prot:P54490" /translation="MNILMLSPEHPDEPKSGLGVHLNRLISYLNPHINITVFTPSGQL FSYAKFEDYIADANFTMVRHVLSHNKRFDLIHAHDDTTAPAAQYLKQRLGLPLAATIH GLESERKKVCREAPHPYRLMTERLLIESADALIVLSTFMKRSLDKAAHKKITVIPSPA SMEEEKGKIPRSMNRRFLFSYGRFVPEKGLSQLLKVFAILKQRQPDLYLVLAGEGPSL SCYEKLAAAYNLKDRVMFLPFLNRKDIRTLLSHCEMAVFPSSYEPFGLAAQESMEQGV LTVVSQSGGFCDYAVHDKTAIIADFTLVQEAADLLDSFLKDREKARRIKEAGRQQVFK LHHPRLIMSSYLQLYERIFNNSAIH*" /label="yqgM CDS" gene complement(2244055..2245134) /gene="yqgM" /locus_tag="BSU_24910" /old_locus_tag="BSU24910" /label="yqgM gene" CDS complement(2245131..2245601) /gene="yqgL" /locus_tag="BSU_24920" /old_locus_tag="BSU24920" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390371.1" /db_xref="EnsemblGenomes-Gn:BSU24920" /db_xref="EnsemblGenomes-Tr:CAB14422" /db_xref="SubtiList:BG11679" /db_xref="UniProtKB/Swiss-Prot:P54489" /translation="MDKHPFPYNIRHKLSFFRDTFDIIIQNAHTLTVSWEISEETMRL AEAVLFEKTQDMIKELRIVIKRKDIEAVRTKRTTYDKGEWTIRQAAGDAVYRAEYRIV NSMNVSLKLAGTDDIYLDENGIRHINSFQIEEAHTRWEAQFSAYTCYGRGEKER*" /label="yqgL CDS" gene complement(2245131..2245601) /gene="yqgL" /locus_tag="BSU_24920" /old_locus_tag="BSU24920" /label="yqgL gene" promotor_-35 2245546..2245554 /Source="Nicolas_upshift_promotors" /id="U1934" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=1724 /SigmaFactorBS="aaggtgtgagcgttttgaatgattatgtcgaatgtgTCCCTA AAAaaggaaagcttatGTCGTATATtatagggaaatgggtgtttatccatggactcct a" /listShort="S935, yqzD, yqzC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2245568..2245576 /Source="Nicolas_upshift_promotors" /id="U1934" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=1724 /SigmaFactorBS="aaggtgtgagcgttttgaatgattatgtcgaatgtgTCCCTA AAAaaggaaagcttatGTCGTATATtatagggaaatgggtgtttatccatggactcct a" /listShort="S935, yqzD, yqzC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2245569..2245742 /Source="Nicolas_S_feature" /locus_tag="new_2576155_2576328" /HighExp="M9-stat, T1.0H, T1.30H, T0.30H, T2.0H, T2.30H, T3.0H, Lbstat, T3.30H, B60" /AntisenseName="yqgL" /AntisenseCor="0.210779859401483" /AntisenseRegPval="-3.3" /CDS_PredictionProba="NA" /TUshortSig="SigI" /TUshortPSig="0.982" /TUlongSig="NA" /TUlongPSig="NA" /label="S935" upshifts 2245570 /Source="Nicolas_upshifts" /id="U1934" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=1724 /SigmaFactorBS="aaggtgtgagcgttttgaatgattatgtcgaatgtgTCCCTA AAAaaggaaagcttatGTCGTATATtatagggaaatgggtgtttatccatggactcct a" /listShort="S935, yqzD, yqzC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2245637..2245656) /Source="Nicolas_upshift_promotors" /id="U1935" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.768231768231768" /psig="0.999000999001" /xcortree=2933 /SigmaFactorBS="cgcgaaaaaaacgagattttgtcgagaaatctttCTTCGCTT cttcttcatgtAATGGTTTAATAGGAACACGaagtgaacgattggaaaggagaatgtt a" /listShort="yqgL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2245649) /Source="Nicolas_upshifts" /id="U1935" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.768231768231768" /psig="0.999000999001" /xcortree=2933 /SigmaFactorBS="cgcgaaaaaaacgagattttgtcgagaaatctttCTTCGCTT cttcttcatgtAATGGTTTAATAGGAACACGaagtgaacgattggaaaggagaatgtt a" /listShort="yqgL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2245668..2245675) /Source="Nicolas_upshift_promotors" /id="U1935" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.768231768231768" /psig="0.999000999001" /xcortree=2933 /SigmaFactorBS="cgcgaaaaaaacgagattttgtcgagaaatctttCTTCGCTT cttcttcatgtAATGGTTTAATAGGAACACGaagtgaacgattggaaaggagaatgtt a" /listShort="yqgL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2245714..2245718 /Source="Nicolas_upshift_promotors" /id="U1936" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.806193806193806" /psig="0.995004995004995" /xcortree=2671 /SigmaFactorBS="ctcgacaaaatctcgtttttttcgcgaattCCTTTagaaact attggtttTATGGTATAAAAAAGAAGGAtaaaaaaagaatagaaggtgatgaaacgtg g" /listShort="yqzD, yqzC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2245734..2245753 /Source="Nicolas_upshift_promotors" /id="U1936" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.806193806193806" /psig="0.995004995004995" /xcortree=2671 /SigmaFactorBS="ctcgacaaaatctcgtttttttcgcgaattCCTTTagaaact attggtttTATGGTATAAAAAAGAAGGAtaaaaaaagaatagaaggtgatgaaacgtg g" /listShort="yqzD, yqzC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2245744 /Source="Nicolas_upshifts" /id="U1936" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.806193806193806" /psig="0.995004995004995" /xcortree=2671 /SigmaFactorBS="ctcgacaaaatctcgtttttttcgcgaattCCTTTagaaact attggtttTATGGTATAAAAAAGAAGGAtaaaaaaagaatagaaggtgatgaaacgtg g" /listShort="yqzD, yqzC" /GFF_Attribute="listLong" /label="upshifts" CDS 2245781..2246134 /gene="yqzD" /locus_tag="BSU_24930" /old_locus_tag="BSU24930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390372.1" /db_xref="EnsemblGenomes-Gn:BSU24930" /db_xref="EnsemblGenomes-Tr:CAB14423" /db_xref="GOA:O32022" /db_xref="SubtiList:BG13770" /db_xref="UniProtKB/Swiss-Prot:O32022" /translation="MEIAIIALFIVSIALIAFSYSQRDPMKDVEQELETLQLSAMQEI YKLKKKMTVLEEELLETNLVIRKSKQNDINQKIAKQILSKYNNGMSAEAIAKAEHVSV EDVNTIIKDNEKVLV*" /label="yqzD CDS" gene 2245781..2246134 /gene="yqzD" /locus_tag="BSU_24930" /old_locus_tag="BSU24930" /label="yqzD gene" CDS 2246131..2246595 /gene="yqzC" /locus_tag="BSU_24940" /old_locus_tag="BSU24940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390373.2" /db_xref="EnsemblGenomes-Gn:BSU24940" /db_xref="EnsemblGenomes-Tr:CAB14424" /db_xref="InterPro:IPR003770" /db_xref="SubtiList:BG13769" /db_xref="UniProtKB/Swiss-Prot:O32023" /translation="MTKRGIQAFAGGIILATAVLAAVFYLTDEDQAAAVKDNKTVTEQ DVNNYLDSKKLVSVNRDEYQKLLDSKEKSLNNDSGSDTKSDKVKTYKLTIKDGMSTAD VSAILEKEGIISSAQDFNDYVIDAGYHKEIRAGEFKVKSDMSFKKIVKTLTR*" /label="yqzC CDS" gene 2246131..2246595 /gene="yqzC" /locus_tag="BSU_24940" /old_locus_tag="BSU24940" /label="yqzC gene" downshifts 2246581 /Source="Nicolas_upshifts" /id="D1293" /incds=0 /nref=216 /ntot=264 /MaxReadThrough="0.9847" /MaxDrop="6.07831" /score="21.2108939" /energy="-8.8" /TU="NA" /idTUdmin="U1934" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2246624..2247406) /gene="pstBB" /locus_tag="BSU_24950" /old_locus_tag="BSU24950" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8760913, 9098050, 12897025, 15289558" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8760913, 9098050, 12897025, 15289558; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphate ABC transporter (ATP-binding protein)" /protein_id="NP_390374.1" /db_xref="EnsemblGenomes-Gn:BSU24950" /db_xref="EnsemblGenomes-Tr:CAB14425" /db_xref="GOA:P46342" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005670" /db_xref="InterPro:IPR015850" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11379" /db_xref="UniProtKB/Swiss-Prot:P46342" /translation="MSIATEAVMKQEVYQVNGMNLWYGQHHALKNINLSIYENEVTAI IGPSGCGKSTFIKTLNLMIQMTPNVKLAGELNYNGSNILKDKVDIVDLRKNIGMVFQK GNPFPQSIFDNVAYGPRVHGTKNKKKLQEIVEKSLKDVALWDEVKDRLHTSALSLSGG QQQRLCIARALATNPDILLMDEPTSALDPISTRKIEELILELKDKYTIVIVTHNMQQA ARVSDQTAFFYMGELVECDNTNKMFSNPKDQRTLDYISGKFG*" /label="pstBB CDS" gene complement(2246624..2247406) /gene="pstBB" /locus_tag="BSU_24950" /old_locus_tag="BSU24950" /label="pstBB gene" downshifts complement(2246635) /Source="Nicolas_upshifts" /id="D1294" /incds=0 /nref=20 /ntot=46 /MaxReadThrough="2.29658" /MaxDrop="6.53816" /score="26.1659198" /energy="-8.8" /TU="NA" /idTUdmin="U1937" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2247417..2248226) /gene="pstBA" /locus_tag="BSU_24960" /old_locus_tag="BSU24960" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8760913, 9098050, 12897025, 15289558" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8760913, 9098050, 12897025, 15289558; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphate ABC transporter (ATP-binding protein)" /protein_id="NP_390375.1" /db_xref="EnsemblGenomes-Gn:BSU24960" /db_xref="EnsemblGenomes-Tr:CAB14426" /db_xref="GOA:P46341" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005670" /db_xref="InterPro:IPR015850" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11378" /db_xref="UniProtKB/Swiss-Prot:P46341" /translation="MSEQMVKEKPERAVIVPKQNHVLEVKDLSIYYGNKQAVHHVNMD IEKNAVTALIGPSGCGKSTFLRNINRMNDLIPSARAEGEILYEGLNILGGNINVVSLR REIGMVFQKPNPFPKSIYANITHALKYAGERNKAVLDEIVEESLTKAALWDEVKDRLH SSALSLSGGQQQRLCIARTLAMKPAVLLLDEPASALDPISNAKIEELITGLKREYSII IVTHNMQQALRVSDRTAFFLNGELVEYGQTEQIFTSPKKQKTEDYINGKFG*" /label="pstBA CDS" gene complement(2247417..2248226) /gene="pstBA" /locus_tag="BSU_24960" /old_locus_tag="BSU24960" /label="pstBA gene" CDS complement(2248247..2249131) /gene="pstA" /locus_tag="BSU_24970" /old_locus_tag="BSU24970" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9098050, 12897025, 15289558, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9098050, 12897025, 15289558, 15849754, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="phosphate ABC transporter (permease)" /protein_id="NP_390376.2" /db_xref="EnsemblGenomes-Gn:BSU24970" /db_xref="EnsemblGenomes-Tr:CAB14427" /db_xref="GOA:P46340" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR005672" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11377" /db_xref="UniProtKB/Swiss-Prot:P46340" /translation="MNRKITDKLATGMFGLCAAIIAAILVGLFSYIIINGVSQLSFQF ITTKSSAIAAGGGIRDQLFNSFYILFITMLITIPLGVGGGVFMAEYAPNNKVTDFIRT CIEVLSSLPSIVIGMFGLLMFVNLTGWGYTIIGGALALTVFNLPVMVRVTEDAIRSVP KDLKEASLALGVSRWHTVKTVLIPSAIPSIITGAILASGRVFGEAAALLFTAGLTTPR LNFTEWNPFSETSPLNIFRPAETLAVHIWNVNTQGMIPDAEAIANGGSAVLVISVLVF NLAARWLGTMIYKKLTAN*" /label="pstA CDS" gene complement(2248247..2249131) /gene="pstA" /locus_tag="BSU_24970" /old_locus_tag="BSU24970" /label="pstA gene" CDS complement(2249131..2250060) /gene="pstC" /locus_tag="BSU_24980" /old_locus_tag="BSU24980" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9098050, 12897025, 15289558, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9098050, 12897025, 15289558, 15849754, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="phosphate ABC transporter (permease)" /protein_id="NP_390377.2" /db_xref="EnsemblGenomes-Gn:BSU24980" /db_xref="EnsemblGenomes-Tr:CAB14428" /db_xref="GOA:P46339" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR011864" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11376" /db_xref="UniProtKB/Swiss-Prot:P46339" /translation="MINNRENMSVSERLISSRQNRQLDEVRGRMIVTACALIMIAASV AITIFLGVKGLQSFLVNGVSPIEFLTSLNWNPTDSDPKYGVLPFIFGSFAVTILSALI AAPLGIAGAIFMTEIAPNWGKKVLQPVIELLVGIPSVVYGFIGLTVLVPFIAQFKSSG TGHSLLAGTIVLSVMILPTITSISADAMASLPKSLREGSYALGATRWQTIRKVLVPAA FPTLMTAVVLGMARAFGEALAVQMVIGNTRVLPESPFDTAGTLTTIITLNMGHTTYGS VENNTLWSMGLVLLVMSFLFILLIRYLSSRRKV*" /label="pstC CDS" gene complement(2249131..2250060) /gene="pstC" /locus_tag="BSU_24980" /old_locus_tag="BSU24980" /label="pstC gene" CDS complement(2250129..2251031) /gene="pstS" /locus_tag="BSU_24990" /old_locus_tag="BSU24990" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9098050, 9593301, 10913081, 15289558, 21461370, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9098050, 9593301, 10913081, 15289558, 21461370, 25355936; Product type t : transporter" /codon_start=1 /transl_table=11 /product="phosphate ABC transporter (phosphate binding lipoprotein)" /protein_id="NP_390378.1" /db_xref="EnsemblGenomes-Gn:BSU24990" /db_xref="EnsemblGenomes-Tr:CAB14429" /db_xref="GOA:P46338" /db_xref="InterPro:IPR011862" /db_xref="InterPro:IPR024370" /db_xref="SubtiList:BG11375" /db_xref="UniProtKB/Swiss-Prot:P46338" /translation="MKKNKLVLMLLMAAFMMIAAACGNAGESKKSNSDSAKGEEKASG SLTISGSSAMQPLVLAAAEKFMEENPDADIQVQAGGSGTGLSQVSEGAVQIGNSDVFA EEKEGIDAKALVDHQVAVVGMAAAVNPDAGVKDISKDELKKIFTGKIKNWKELGGKDQ KITLVNRPDSSGTRATFVKYALDGAEPAEGITEDSSNTVKKIIADTPGAIGYLAFSYL TDDKVTALSIDGVKPEAKNVATGEYPIWAYQHSYTKGEATGLAKEFLDYLKSEDIQKS IVTDQGYIPVTDMKVTRDANGKQS*" /label="pstS CDS" gene complement(2250129..2251031) /gene="pstS" /locus_tag="BSU_24990" /old_locus_tag="BSU24990" /label="pstS gene" upshifts complement(2251086) /Source="Nicolas_upshifts" /id="U1937" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.014985014985015" /xcortree=7 /SigmaFactorBS="aaaaaacgcactgatttacaaaaCCTtaacattcggTTCAAA CCCTTTTTACAtagaacctttactctatacgtgtaggacaaattacacattatacgca g" /listShort="pstS, pstC, pstA, pstBA, pstBB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2251094..2251110) /Source="Nicolas_upshift_promotors" /id="U1937" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.014985014985015" /xcortree=7 /SigmaFactorBS="aaaaaacgcactgatttacaaaaCCTtaacattcggTTCAAA CCCTTTTTACAtagaacctttactctatacgtgtaggacaaattacacattatacgca g" /listShort="pstS, pstC, pstA, pstBA, pstBB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2251121..2251123) /Source="Nicolas_upshift_promotors" /id="U1937" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.014985014985015" /xcortree=7 /SigmaFactorBS="aaaaaacgcactgatttacaaaaCCTtaacattcggTTCAAA CCCTTTTTACAtagaacctttactctatacgtgtaggacaaattacacattatacgca g" /listShort="pstS, pstC, pstA, pstBA, pstBB" /GFF_Attribute="listLong" /label="promotor_-35" Polymorphism join(2251140,2251142) /Source="geneious" /ID="SNP_BsDelta6_2581727_2581726" /Polymorphism_Type="Insertion (tandem repeat)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=0 /Amino_Acid_Change /CDS_Position /Change="(T)6 -> (T)7" /Codon_Change /Coverage=117 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=114 /comment="-" /modified_by="User" / /label="Polymorphism_Delta6" CDS complement(2251186..2253336) /gene="pbpA" /locus_tag="BSU_25000" /old_locus_tag="BSU25000" /EC_number="3.4.-.-" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9139922, 9851991, 12896990, 17307860" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9139922, 9851991, 12896990, 17307860; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="transpeptidase (penicillin-binding protein 2A)" /protein_id="NP_390379.1" /db_xref="EnsemblGenomes-Gn:BSU25000" /db_xref="EnsemblGenomes-Tr:CAB14430" /db_xref="GOA:P54488" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR005311" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR036138" /db_xref="SubtiList:BG11678" /db_xref="UniProtKB/Swiss-Prot:P54488" /translation="MRRNKPKKQNHKEKKKSLPIRLNILFLAAFVIFTWIIVELGIKQ IVQGDDYKNQANKQEQSEVSSAVPRGKIYDRNFNAIVTNKALNAITYTRSKSTTQEQR LKIAKKLSDMIKVDTKKVTERDKKDYWILTRPKEAKKLISSKERQQVEDKKISDDDLY QLQLKRITDKQLNELTDKDMQILAIKRQMDSGYALTPQYIKNEDVSAKEMAVVSEHLD ELPGVDVTSDWEREYPYKNLLRSVLGSVSSSNEGLPSNLLDHYLSLGYSRNDRVGKSY LEYQYESLLQGQKAKVENITDSKGNVTGTKTVSEGKAGKDLVLTIDIDLQKSVEKIIE KKLKAAKARPSTELLDRAFVVMMDPRNGEVLTMAGKQIKRENGAYKFDDYALGAMTSS YAMGSAVKGATVLTGLQTGAINLNTVFKDEPLYIGQDKRGKKSWQNLGPVGIQTALEK SSNVFMFKTAIAVGKGEYKPHQALPLDTSAFDTFRNYFSQFGLGVKTGIDLPNEMTGY KGTSRLSGFLLDFAIGQYDTYTPLELAQYVSTIANGGYRMKPQLVKEVRDSNAKKGIG AVVDSVQPEVLNKVDMKSSYIEEVQAGFRRVATKGTAAGQLASASYKPAAKTGTAQSF YDGPDKSKTGTDTYNTTLVAYAPADNPEIAISVVVPWTYIDYNQRYSITNEIGREVMD KYFELKSKQDKEGTQQKNKDKIEENAENTTSSDN*" /label="pbpA CDS" gene complement(2251186..2253336) /gene="pbpA" /locus_tag="BSU_25000" /old_locus_tag="BSU25000" /label="pbpA gene" downshifts complement(2251196) /Source="Nicolas_upshifts" /id="D1295" /incds=0 /nref=255 /ntot=278 /MaxReadThrough="1.22121" /MaxDrop="8.82988" /score="31.2726004" /energy="-10" /TU="U1940" /idTUdmin="U1938" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2251930..2251948) /Source="Nicolas_upshift_promotors" /id="U1938" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=129 /SigmaFactorBS="gcattagagaagtcatcaaacgtttttaTGTTTAAaacagca attgcagtTGGTAAAGGTGAATATAAAcctcaccaagcattgcctttggatacttctg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2251938) /Source="Nicolas_upshifts" /id="U1938" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=129 /SigmaFactorBS="gcattagagaagtcatcaaacgtttttaTGTTTAAaacagca attgcagtTGGTAAAGGTGAATATAAAcctcaccaagcattgcctttggatacttctg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2251964..2251970) /Source="Nicolas_upshift_promotors" /id="U1938" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=129 /SigmaFactorBS="gcattagagaagtcatcaaacgtttttaTGTTTAAaacagca attgcagtTGGTAAAGGTGAATATAAAcctcaccaagcattgcctttggatacttctg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2252625..2252644) /Source="Nicolas_upshift_promotors" /id="U1939" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1230 /SigmaFactorBS="tggtaagtgaacatttagacgaactgccaggtgttGATGTCA CGTccgattgggaacgTGAATATCCTTATAAAAACCttcttcgctcagtgctcggaag t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2252642) /Source="Nicolas_upshifts" /id="U1939" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1230 /SigmaFactorBS="tggtaagtgaacatttagacgaactgccaggtgttGATGTCA CGTccgattgggaacgTGAATATCCTTATAAAAACCttcttcgctcagtgctcggaag t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2252658..2252667) /Source="Nicolas_upshift_promotors" /id="U1939" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1230 /SigmaFactorBS="tggtaagtgaacatttagacgaactgccaggtgttGATGTCA CGTccgattgggaacgTGAATATCCTTATAAAAACCttcttcgctcagtgctcggaag t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2253386..2253405) /Source="Nicolas_upshift_promotors" /id="U1940" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.773226773226773" /psig="0.994005994005994" /xcortree=2518 /SigmaFactorBS="aatttttttgccaaaaaggggttatcTGTAGaaaaaagtcga aaaaACCTTTAAAATGAAAACTGGcactcttacttgagtgtcttttctttctgtaaat a" /listShort="pbpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2253391) /Source="Nicolas_upshifts" /id="U1940" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.773226773226773" /psig="0.994005994005994" /xcortree=2518 /SigmaFactorBS="aatttttttgccaaaaaggggttatcTGTAGaaaaaagtcga aaaaACCTTTAAAATGAAAACTGGcactcttacttgagtgtcttttctttctgtaaat a" /listShort="pbpA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2253421..2253425) /Source="Nicolas_upshift_promotors" /id="U1940" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.773226773226773" /psig="0.994005994005994" /xcortree=2518 /SigmaFactorBS="aatttttttgccaaaaaggggttatcTGTAGaaaaaagtcga aaaaACCTTTAAAATGAAAACTGGcactcttacttgagtgtcttttctttctgtaaat a" /listShort="pbpA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2253450..2254742) /gene="yqgE" /locus_tag="BSU_25010" /old_locus_tag="BSU25010" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_390380.2" /db_xref="EnsemblGenomes-Gn:BSU25010" /db_xref="EnsemblGenomes-Tr:CAB14431" /db_xref="GOA:P54487" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11677" /db_xref="UniProtKB/Swiss-Prot:P54487" /translation="MSKLKKVIGDVDVNKGLLFLLTIGGLYSLGIALSNTFVNVYLWK QSGKFIDLAIYNLSIVTMQPITFYLAGRLAKKIDRVFILRFGVIFLAAFYLSVLLAGE TAASRLVLIGAVLGVGYGFYWLAFNVLTFEITEPDTRDFFNGFMGILSSSAGMIGPIV AGFVISRLENNTGYTVIFSLSLSLFALAVVMSFFLKRRESKGRFMLSKVFGERHSNMN WRRITNAHFFQGLREGIFVFLISVFVFIETNSELALGTFGLVNSAVSFFAYYFASRLI KKKARKKSILLGGLILYGALFLILFHMSFSTLLTYGVFIAIGYPLLLVPYVSLTYDVI GRARHARKARIEYIVLREMFLNAGRIVSILCFLLIVALLKEDVGIPLSLAILGIGHPL IYYFVKDIRFKEKEGENETMEEDGQKRVTEPTLLKGER*" /label="yqgE CDS" gene complement(2253450..2254742) /gene="yqgE" /locus_tag="BSU_25010" /old_locus_tag="BSU25010" /label="yqgE gene" promotor_-10 complement(2254765..2254776) /Source="Nicolas_upshift_promotors" /id="U1941" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=934 /SigmaFactorBS="ggtcctcattatgggaccttgtttttttatgtcttcttttTA CATATctcggtttgagtgAGACAGACTAAGggatagtaaaggggagtcagtaatgagc a" /listShort="yqgE, pbpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2254776) /Source="Nicolas_upshifts" /id="U1941" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=934 /SigmaFactorBS="ggtcctcattatgggaccttgtttttttatgtcttcttttTA CATATctcggtttgagtgAGACAGACTAAGggatagtaaaggggagtcagtaatgagc a" /listShort="yqgE, pbpA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2254790..2254796) /Source="Nicolas_upshift_promotors" /id="U1941" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=934 /SigmaFactorBS="ggtcctcattatgggaccttgtttttttatgtcttcttttTA CATATctcggtttgagtgAGACAGACTAAGggatagtaaaggggagtcagtaatgagc a" /listShort="yqgE, pbpA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2254849..2255457) /gene="sodA" /locus_tag="BSU_25020" /old_locus_tag="BSU25020" /EC_number="1.15.1.1" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9393707, 9573176, 9658017, 10074093, 15897454, 18084079, 25445927" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9393707, 9573176, 9658017, 10074093, 15897454, 18084079, 25445927; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="superoxide dismutase (Mn[2+]-dependent)" /protein_id="NP_390381.3" /db_xref="EnsemblGenomes-Gn:BSU25020" /db_xref="EnsemblGenomes-Tr:CAB14432" /db_xref="GOA:P54375" /db_xref="InterPro:IPR001189" /db_xref="InterPro:IPR019831" /db_xref="InterPro:IPR019832" /db_xref="InterPro:IPR019833" /db_xref="InterPro:IPR036314" /db_xref="InterPro:IPR036324" /db_xref="PDB:2RCV" /db_xref="SubtiList:BG11676" /db_xref="UniProtKB/Swiss-Prot:P54375" /translation="MAYELPELPYAYDALEPHIDKETMTIHHTKHHNTYVTNLNKAVE GNTALANKSVEELVADLDSVPENIRTAVRNNGGGHANHKLFWTLLSPNGGGEPTGALA EEINSVFGSFDKFKEQFAAAAAGRFGSGWAWLVVNNGKLEITSTPNQDSPLSEGKTPI LGLDVWEHAYYLNYQNRRPDYISAFWNVVNWDEVARLYSEAK*" /label="sodA CDS" gene complement(2254849..2255457) /gene="sodA" /locus_tag="BSU_25020" /old_locus_tag="BSU25020" /label="sodA gene" downshifts complement(2254864) /Source="Nicolas_upshifts" /id="D1296" /incds=0 /nref=265 /ntot=268 /MaxReadThrough="4.329" /MaxDrop="9.16338" /score="3.26408916" /energy="-8.1" /TU="U1943" /idTUdmin="U1942" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2255509..2255528) /Source="Nicolas_upshift_promotors" /id="U1942" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.671328671328671" /psig="0.998001998001998" /xcortree=102 /SigmaFactorBS="cgctgaaatgagccaaatcgtgagctttttCATTGATTacaa agcattctttTGTTACATTGAATGAAGAAAggctcgctgtgaagcggcatttcagtac a" /listShort="sodA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2255520) /Source="Nicolas_upshifts" /id="U1942" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.671328671328671" /psig="0.998001998001998" /xcortree=102 /SigmaFactorBS="cgctgaaatgagccaaatcgtgagctttttCATTGATTacaa agcattctttTGTTACATTGAATGAAGAAAggctcgctgtgaagcggcatttcagtac a" /listShort="sodA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2255522..2255590) /Source="Nicolas_S_feature" /locus_tag="new_2586107_2586175_c" /HighExp="Etha, Salt, Heat, LPhT, Gly, Sw, S4, LoTm, M9-stat, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="0.997, 1" /TUlongSig="SigB" /TUlongPSig="0.999" /label="S936" promotor_-35 complement(2255543..2255550) /Source="Nicolas_upshift_promotors" /id="U1942" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.671328671328671" /psig="0.998001998001998" /xcortree=102 /SigmaFactorBS="cgctgaaatgagccaaatcgtgagctttttCATTGATTacaa agcattctttTGTTACATTGAATGAAGAAAggctcgctgtgaagcggcatttcagtac a" /listShort="sodA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2255581..2255599) /Source="Nicolas_upshift_promotors" /id="U1943" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=263 /SigmaFactorBS="tggacggtcctataagaaatgctggcggcaGGTTTAAtgggg cagattatcGGTTAAAGTGAAATATGTCcgctgaaatgagccaaatcgtgagcttttt c" /listShort="S936, sodA, yqgE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2255590) /Source="Nicolas_upshifts" /id="U1943" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=263 /SigmaFactorBS="tggacggtcctataagaaatgctggcggcaGGTTTAAtgggg cagattatcGGTTAAAGTGAAATATGTCcgctgaaatgagccaaatcgtgagcttttt c" /listShort="S936, sodA, yqgE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2255614..2255620) /Source="Nicolas_upshift_promotors" /id="U1943" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=263 /SigmaFactorBS="tggacggtcctataagaaatgctggcggcaGGTTTAAtgggg cagattatcGGTTAAAGTGAAATATGTCcgctgaaatgagccaaatcgtgagcttttt c" /listShort="S936, sodA, yqgE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2255636..2256118) /gene="yqgC" /locus_tag="BSU_25030" /old_locus_tag="BSU25030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406; Product type m:membrane component" /codon_start=1 /transl_table=11 /product="conserved integral inner membrane protein of unknown function" /protein_id="NP_390382.1" /db_xref="EnsemblGenomes-Gn:BSU25030" /db_xref="EnsemblGenomes-Tr:CAB14433" /db_xref="GOA:P54486" /db_xref="InterPro:IPR007403" /db_xref="SubtiList:BG11675" /db_xref="UniProtKB/Swiss-Prot:P54486" /translation="MDMLYWLLIAAVFIIAFIGLVYPVIPSVVFIVAGFVLYGFLFSF SPYSYMFWLVEAVFAAVLFAADYVSNLLGVKRFGGSKAAIWGSTIGLLIGPFVIPVAG IILGPFIGAVCAELIVHQKDLKSAFKIGLGSLIGFLTGVIAKGIIQLLMIGYFLWTVL *" /label="yqgC CDS" gene complement(2255636..2256118) /gene="yqgC" /locus_tag="BSU_25030" /old_locus_tag="BSU25030" /label="yqgC gene" S_feature complement(2256119..2256411) /Source="Nicolas_S_feature" /locus_tag="new_2586704_2586996_c" /HighExp="Etha, Gly, Salt, aero, S0, LoTm, HiTm, LPh, nit, ferm" /AntisenseName="yqgB" /AntisenseCor="9.8584854910492598E-2" /AntisenseRegPval="-1" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S937" promotor_-35 2256161..2256167 /Source="Nicolas_upshift_promotors" /id="U1944" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.36963036963037" /psig="0.731268731268731" /xcortree=2372 /SigmaFactorBS="ttttactctgtcttcttcatgtcttcCTTGTATtcacacgca tgcaaCGATACAATAAGCAACATATattagtttagctaggaagtgaagatagtgaatg t" /listShort="yqgB, S939" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2256182..2256201 /Source="Nicolas_upshift_promotors" /id="U1944" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.36963036963037" /psig="0.731268731268731" /xcortree=2372 /SigmaFactorBS="ttttactctgtcttcttcatgtcttcCTTGTATtcacacgca tgcaaCGATACAATAAGCAACATATattagtttagctaggaagtgaagatagtgaatg t" /listShort="yqgB, S939" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2256195 /Source="Nicolas_upshifts" /id="U1944" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.36963036963037" /psig="0.731268731268731" /xcortree=2372 /SigmaFactorBS="ttttactctgtcttcttcatgtcttcCTTGTATtcacacgca tgcaaCGATACAATAAGCAACATATattagtttagctaggaagtgaagatagtgaatg t" /listShort="yqgB, S939" /GFF_Attribute="listLong" /label="upshifts" CDS 2256228..2256995 /gene="yqgB" /locus_tag="BSU_25040" /old_locus_tag="BSU25040" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 15294815; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="factor involved in motility" /protein_id="NP_390383.2" /db_xref="EnsemblGenomes-Gn:BSU25040" /db_xref="EnsemblGenomes-Tr:CAB14434" /db_xref="GOA:P54485" /db_xref="InterPro:IPR009574" /db_xref="SubtiList:BG11674" /db_xref="UniProtKB/Swiss-Prot:P54485" /translation="MNVFQLFIKSTYSPRDIAKTRFQGIGKAILYVFLLSVLFAIPTA YYVSTGTVKSMNGFKTVLNKDFPDFTISNGKLQTDEKKATESQANGFVIVFDPTDSYG TEQIEAKQNAIGILQNKFVLAIDGQAQEMSYSMMPSELQKKDVIAGLNQNKAMIVTVL SALIFLVTAAGKFIEVSFLALIGLIIKNSQKKHLSYHQLWKLSAYSITLSTVFFTIMR ALEATVPSEFLLNWFVNFVILFLVLKEIPSKKVINKS*" /label="yqgB CDS" gene 2256228..2256995 /gene="yqgB" /locus_tag="BSU_25040" /old_locus_tag="BSU25040" /label="yqgB gene" promotor_-10 complement(2256409..2256427) /Source="Nicolas_upshift_promotors" /id="U1945" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=174 /SigmaFactorBS="ttttctcatccgtttgaagtttgcCGTTTGAaattgtgaaat caGGGAAATCTTTGTTTAAAAcagttttaaagccgttcattgattttacggtccctgt a" /listShort="S937, yqgC" /listLong="S936, sodA, yqgE" /label="promotor_-10" upshifts complement(2256411) /Source="Nicolas_upshifts" /id="U1945" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=174 /SigmaFactorBS="ttttctcatccgtttgaagtttgcCGTTTGAaattgtgaaat caGGGAAATCTTTGTTTAAAAcagttttaaagccgttcattgattttacggtccctgt a" /listShort="S937, yqgC" /listLong="S936, sodA, yqgE" /label="upshifts" S_feature complement(2256413..2257349) /Source="Nicolas_S_feature" /locus_tag="new_2586998_2587934_c" /HighExp="S0, S1, aero, M0t45, HPh, Lbtran, LPh, GM 120, nit, M/G" /AntisenseName="yqgB" /AntisenseCor="0.31978785018705103" /AntisenseRegPval="-7.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S938" promotor_-35 complement(2256441..2256447) /Source="Nicolas_upshift_promotors" /id="U1945" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=174 /SigmaFactorBS="ttttctcatccgtttgaagtttgcCGTTTGAaattgtgaaat caGGGAAATCTTTGTTTAAAAcagttttaaagccgttcattgattttacggtccctgt a" /listShort="S937, yqgC" /listLong="S936, sodA, yqgE" /label="promotor_-35" S_feature 2256996..2257426 /Source="Nicolas_S_feature" /locus_tag="new_2587581_2588011" /HighExp="C30, HiOs, UNK1, Gly, Fru, S8, Salt, MG 5, S7, MG 25" /AntisenseName="yqgA" /AntisenseCor="0.170248276038857" /AntisenseRegPval="-2.2999999999999998" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.731" /TUlongSig="NA" /TUlongPSig="NA" /label="S939" downshifts 2257383 /Source="Nicolas_upshifts" /id="D1297" /incds=0 /nref=5 /ntot=131 /MaxReadThrough="3.89102" /MaxDrop="3.29021" /score="30.8580926" /energy="-13.8" /TU="U1944" /idTUdmin="U1944" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" downshifts complement(2257394) /Source="Nicolas_upshifts" /id="D1298" /incds=0 /nref=15 /ntot=207 /MaxReadThrough="6.7306" /MaxDrop="3.9194" /score="7.48192829" /energy="-14.3" /TU="U1947" /idTUdmin="U1945" /TUdmin="-1848" /isTUend="FALSE" /label="downshifts" CDS complement(2257411..2257839) /gene="yqgA" /locus_tag="BSU_25050" /old_locus_tag="BSU25050" /experiment="publication(s) with functional evidences, PMID:25130749, 27797724" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25130749, 27797724; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="cell wall protein" /protein_id="NP_390384.2" /db_xref="EnsemblGenomes-Gn:BSU25050" /db_xref="EnsemblGenomes-Tr:CAB14435" /db_xref="GOA:P54484" /db_xref="SubtiList:BG11673" /db_xref="UniProtKB/Swiss-Prot:P54484" /translation="MKQGKFSVFLILLLMLTLVVAPKEKAEAASSGWQPVSGISGCKI RVITDAYTYTKSATSIDAYAETNGKCGKLNYKSFGVSIVEGGDIGPQYSGYFSSRTPT KKFYFSKLPKPTGTPWAVGLSVYKGKAKGAAFVYINPQKR*" /label="yqgA CDS" gene complement(2257411..2257839) /gene="yqgA" /locus_tag="BSU_25050" /old_locus_tag="BSU25050" /label="yqgA gene" promotor_-35 2257835..2257839 /Source="Nicolas_upshift_promotors" /id="U1946" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=294 /SigmaFactorBS="tagtagcaaaattaaaaacacagaaaattttccttgcTTCAT tttgtagatCCTCCTTTAAACTATtacataattatcctaacagatccattgttcattg t" /listShort="yqfZ" /listLong="S940, ispG" /label="promotor_-35" promotor_-10 2257849..2257863 /Source="Nicolas_upshift_promotors" /id="U1946" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=294 /SigmaFactorBS="tagtagcaaaattaaaaacacagaaaattttccttgcTTCAT tttgtagatCCTCCTTTAAACTATtacataattatcctaacagatccattgttcattg t" /listShort="yqfZ" /listLong="S940, ispG" /label="promotor_-10" upshifts 2257858 /Source="Nicolas_upshifts" /id="U1946" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=294 /SigmaFactorBS="tagtagcaaaattaaaaacacagaaaattttccttgcTTCAT tttgtagatCCTCCTTTAAACTATtacataattatcctaacagatccattgttcattg t" /listShort="yqfZ" /listLong="S940, ispG" /label="upshifts" promotor_-10 complement(2257862..2257881) /Source="Nicolas_upshift_promotors" /id="U1947" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2294 /SigmaFactorBS="agatcaaaaagaggcttttataatataaaactcgtattccat TATTTACAatgaacaatggatcTGTTAGGATAATTATGTAATagtttaaaggaggatc t" /listShort="yqgA, S938, S937, yqgC, S936" /listLong="sodA" /label="promotor_-10" upshifts complement(2257885) /Source="Nicolas_upshifts" /id="U1947" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2294 /SigmaFactorBS="agatcaaaaagaggcttttataatataaaactcgtattccat TATTTACAatgaacaatggatcTGTTAGGATAATTATGTAATagtttaaaggaggatc t" /listShort="yqgA, S938, S937, yqgC, S936" /listLong="sodA" /label="upshifts" promotor_-35 complement(2257896..2257903) /Source="Nicolas_upshift_promotors" /id="U1947" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2294 /SigmaFactorBS="agatcaaaaagaggcttttataatataaaactcgtattccat TATTTACAatgaacaatggatcTGTTAGGATAATTATGTAATagtttaaaggaggatc t" /listShort="yqgA, S938, S937, yqgC, S936" /listLong="sodA" /label="promotor_-35" promotor_-35 2258054..2258059 /Source="Nicolas_upshift_promotors" /id="U1948" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=967 /SigmaFactorBS="ccgagcattcgcagtctcttttcttttGTCATGaatcgaaat ggacaaGCATACTATGGTATAAAATttcgtatgcgggaggaaaagcgatgaagcgtct c" /listShort="yqfZ, S940, ispG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2258075..2258093 /Source="Nicolas_upshift_promotors" /id="U1948" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=967 /SigmaFactorBS="ccgagcattcgcagtctcttttcttttGTCATGaatcgaaat ggacaaGCATACTATGGTATAAAATttcgtatgcgggaggaaaagcgatgaagcgtct c" /listShort="yqfZ, S940, ispG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2258087 /Source="Nicolas_upshifts" /id="U1948" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=967 /SigmaFactorBS="ccgagcattcgcagtctcttttcttttGTCATGaatcgaaat ggacaaGCATACTATGGTATAAAATttcgtatgcgggaggaaaagcgatgaagcgtct c" /listShort="yqfZ, S940, ispG" /GFF_Attribute="listLong" /label="upshifts" CDS 2258116..2258415 /gene="yqfZ" /locus_tag="BSU_25060" /old_locus_tag="BSU25060" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15294815; Product type ph : phenotype" /codon_start=1 /transl_table=11 /product="factor involved in motility" /protein_id="NP_390385.1" /db_xref="EnsemblGenomes-Gn:BSU25060" /db_xref="EnsemblGenomes-Tr:CAB14436" /db_xref="GOA:P54483" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR020506" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG11672" /db_xref="UniProtKB/Swiss-Prot:P54483" /translation="MKRLTLVCSIVFILFILFYDLKIGTIPIQDLPVYEASAKTAVQE PAYKTVKVKPGDTVMSIVGSAGSPDDIVKDFEALNPNVKANAIQAGTAYKFPVYP*" /label="yqfZ CDS" gene 2258116..2258415 /gene="yqfZ" /locus_tag="BSU_25060" /old_locus_tag="BSU25060" /label="yqfZ gene" promotor_-35 2258428..2258435 /Source="Nicolas_upshift_promotors" /id="U1949" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.613386613386613" /psig="0.999000999001" /xcortree=1976 /SigmaFactorBS="ccggtctacccttaatttaacgttaatTTCTTGTCagttcgg cgaagacACTGTTACAATGTAATTTGTaaaataaattcacataaaccatactagaatt g" /listShort="S940, ispG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2258450..2258469 /Source="Nicolas_upshift_promotors" /id="U1949" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.613386613386613" /psig="0.999000999001" /xcortree=1976 /SigmaFactorBS="ccggtctacccttaatttaacgttaatTTCTTGTCagttcgg cgaagacACTGTTACAATGTAATTTGTaaaataaattcacataaaccatactagaatt g" /listShort="S940, ispG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2258461..2258537 /Source="Nicolas_S_feature" /locus_tag="new_2589046_2589122" /HighExp="Diami, dia5, dia15, H2O2, Etha, Salt, LBGexp, Oxctl, Paraq, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="0.999, 1" /TUlongSig="Sig-" /TUlongPSig=0 /label="S940" upshifts 2258461 /Source="Nicolas_upshifts" /id="U1949" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.613386613386613" /psig="0.999000999001" /xcortree=1976 /SigmaFactorBS="ccggtctacccttaatttaacgttaatTTCTTGTCagttcgg cgaagacACTGTTACAATGTAATTTGTaaaataaattcacataaaccatactagaatt g" /listShort="S940, ispG" /GFF_Attribute="listLong" /label="upshifts" CDS 2258538..2259671 /gene="ispG" /locus_tag="BSU_25070" /old_locus_tag="BSU25070" /EC_number="1.17.7.1" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12571359, 16268586, 25212876; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase)" /protein_id="NP_390386.1" /db_xref="EnsemblGenomes-Gn:BSU25070" /db_xref="EnsemblGenomes-Tr:CAB14437" /db_xref="GOA:P54482" /db_xref="InterPro:IPR004588" /db_xref="InterPro:IPR011005" /db_xref="InterPro:IPR016425" /db_xref="InterPro:IPR036849" /db_xref="SubtiList:BG11671" /db_xref="UniProtKB/Swiss-Prot:P54482" /translation="MQVSEITHRTKTRPVKVGPLTIGGNNEVVIQSMTTTKTHDVEAT VAEINRLAEAGCQIVRVACPDERAANAIADIKKRISIPLVVDIHFDYKLALKAIEGGA DKIRINPGNIGRREKVEAVVKAAKDKGIPIRIGVNAGSLEKRILEKYGYPTADGMVES ALHHIKILEDLDFHDIIVSMKASDVNLAIEAYEKAAKAFDYPLHLGITESGTLFAGTV KSAAGLGAILSKGIGNTMRISLSADPVEEVKVARELLKSFGLASNAATLISCPTCGRI EIDLISIANEVEEYISKIKAPIKVAVLGCAVNGPGEAREADIGIAGARGEGLLFRKGK IVRKVPEETMVEELKKEIDILAEEHYAKLEAEKAKLKEETQKA*" /label="ispG CDS" gene 2258538..2259671 /gene="ispG" /locus_tag="BSU_25070" /old_locus_tag="BSU25070" /label="ispG gene" downshifts 2259652 /Source="Nicolas_upshifts" /id="D1299" /incds=0 /nref=230 /ntot=267 /MaxReadThrough="2.62035" /MaxDrop="8.92434" /score="30.8580926" /energy="-13.8" /TU="NA" /idTUdmin="U1948" /TUdmin=3 /isTUend="TRUE" /label="downshifts" CDS complement(2259697..2260086) /gene="yqfX" /locus_tag="BSU_25080" /old_locus_tag="BSU25080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 17322312, 22882546" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function expressed in germinating spores" /protein_id="NP_390387.1" /db_xref="EnsemblGenomes-Gn:BSU25080" /db_xref="EnsemblGenomes-Tr:CAB14438" /db_xref="GOA:P54481" /db_xref="SubtiList:BG11670" /db_xref="UniProtKB/Swiss-Prot:P54481" /translation="MKVANDYEKRDNNSYYVDHGSEGTNITRDNDGFFEETAAEIAEP YRAADRSNDQDNDRSGGNVNEGRGIGYIALALSIISLFVLPVLLGAAGIIVGYIARRR GAQGLGAWAMGIGVVSLVLGIFIIPFF*" /label="yqfX CDS" gene complement(2259697..2260086) /gene="yqfX" /locus_tag="BSU_25080" /old_locus_tag="BSU25080" /label="yqfX gene" downshifts complement(2259723) /Source="Nicolas_upshifts" /id="D1300" /incds=0 /nref=10 /ntot=62 /MaxReadThrough="1.85077" /MaxDrop="8.74353" /score="28.1764525" /energy="-13.8" /TU="NA" /idTUdmin="U1950" /TUdmin=2 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2260117..2260128) /Source="Nicolas_upshift_promotors" /id="U1950" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=841 /SigmaFactorBS="ataaacaattgacattaacagaaaagtttagcaAACATGAat caggcaaaatgGATCAAACTATAaaagctcctttaataaaacagaagggggaattgaa g" /listShort="yqfX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2260121) /Source="Nicolas_upshifts" /id="U1950" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=841 /SigmaFactorBS="ataaacaattgacattaacagaaaagtttagcaAACATGAat caggcaaaatgGATCAAACTATAaaagctcctttaataaaacagaagggggaattgaa g" /listShort="yqfX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2260142..2260148) /Source="Nicolas_upshift_promotors" /id="U1950" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=841 /SigmaFactorBS="ataaacaattgacattaacagaaaagtttagcaAACATGAat caggcaaaatgGATCAAACTATAaaagctcctttaataaaacagaagggggaattgaa g" /listShort="yqfX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2260161..2260168 /Source="Nicolas_upshift_promotors" /id="U1951" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.971028971028971" /psig="0.999000999001" /xcortree=587 /SigmaFactorBS="agtttgatccattttgcctgattcatgtttgctaaacttttC TGTTAATgtcaattgttTATGTTACACTTGAAGGGATgaaactgaaggagtgtgggca t" /listShort="yqfW, S941" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2260179..2260198 /Source="Nicolas_upshift_promotors" /id="U1951" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.971028971028971" /psig="0.999000999001" /xcortree=587 /SigmaFactorBS="agtttgatccattttgcctgattcatgtttgctaaacttttC TGTTAATgtcaattgttTATGTTACACTTGAAGGGATgaaactgaaggagtgtgggca t" /listShort="yqfW, S941" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2260180 /Source="Nicolas_upshifts" /id="U1951" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.971028971028971" /psig="0.999000999001" /xcortree=587 /SigmaFactorBS="agtttgatccattttgcctgattcatgtttgctaaacttttC TGTTAATgtcaattgttTATGTTACACTTGAAGGGATgaaactgaaggagtgtgggca t" /listShort="yqfW, S941" /GFF_Attribute="listLong" /label="upshifts" CDS 2260219..2260800 /gene="yqfW" /locus_tag="BSU_25090" /old_locus_tag="BSU25090" /EC_number="3.1.3.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative nucleotidase" /protein_id="NP_390388.1" /db_xref="EnsemblGenomes-Gn:BSU25090" /db_xref="EnsemblGenomes-Tr:CAB14439" /db_xref="GOA:P54480" /db_xref="InterPro:IPR009206" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG11669" /db_xref="UniProtKB/Swiss-Prot:P54480" /translation="MLRLGIDIDGTITAQDTFVPYLNRSFNLSISLNDMTDYDLTKLL NITQEEFWDWMNQNEAIIYKEALLAQHAKQSLDLLKEEHKLIYITARRTHLTDITYEW FDRQNIHYDHIELVGGHHKVEAVKNHNIDLFFEDHHGNAMMIAKEAGIPVILFNSPYN QLPIDSNIIRVNNWLEAVQWMNNNKHHLIRVNN*" /label="yqfW CDS" gene 2260219..2260800 /gene="yqfW" /locus_tag="BSU_25090" /old_locus_tag="BSU25090" /label="yqfW gene" downshifts 2260798 /Source="Nicolas_upshifts" /id="D1301" /incds=0 /nref=34 /ntot=240 /MaxReadThrough="4.07255" /MaxDrop="4.44714" /score="-2.90660182" /energy="-8" /TU="U1951" /idTUdmin="U1951" /TUdmin="-611" /isTUend="FALSE" /label="downshifts" S_feature 2260843..2261451 /Source="Nicolas_S_feature" /locus_tag="new_2591428_2592036" /HighExp="LoTm, S8, Cold, S7, S5, Sw, BC, S6, HiOs, B60" /AntisenseName="zur" /AntisenseCor="-0.265512398914523" /AntisenseRegPval="-5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S941" CDS complement(2260843..2261280) /gene="zur" /locus_tag="BSU_25100" /old_locus_tag="BSU25100" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12180919, 12426338, 12904577, 17216355, 21821657, 25213752, 27561249, 28104400" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12180919, 12426338, 12904577, 17216355, 21821657, 25213752, 27561249, 28104400; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (Zn[2+]-binding Fur family)" /protein_id="NP_390389.2" /db_xref="EnsemblGenomes-Gn:BSU25100" /db_xref="EnsemblGenomes-Tr:CAB14440" /db_xref="GOA:P54479" /db_xref="InterPro:IPR002481" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11668" /db_xref="UniProtKB/Swiss-Prot:P54479" /translation="MNVQEALNLLKENGYKYTNKREDMLQLFADSDRYLTAKNVLSAL NDDYPGLSFDTIYRNLSLYEELGILETTELSGEKLFRFKCSFTHHHHHFICLACGKTK EIESCPMDKLCDDLDGYQVSGHKFEIYGTCPDCTAENQENTTA*" /label="zur CDS" gene complement(2260843..2261280) /gene="zur" /locus_tag="BSU_25100" /old_locus_tag="BSU25100" /label="zur gene" downshifts complement(2260847) /Source="Nicolas_upshifts" /id="D1302" /incds=0 /nref=181 /ntot=243 /MaxReadThrough="2.37371" /MaxDrop="6.74703" /score="16.4418277" /energy="-11.9" /TU="U1956" /idTUdmin="U1952" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2261281..2261375) /Source="Nicolas_S_feature" /locus_tag="new_2591866_2591960_c" /HighExp="LPhT, G180, Cold, LBGstat, H2O2, Oxctl, G135, G150, HPh, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S942" promotor_-10 complement(2261371..2261390) /Source="Nicolas_upshift_promotors" /id="U1952" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.428571428571429" /psig=1 /xcortree=2760 /SigmaFactorBS="aaaaacgcaatccactaggctttCATTTACTtttattcattt tatGGGTATAATTTTATCTGCAGtaaagaaaatggcttgctggacagacagctgccat t" /listShort="S942, zur" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2261375) /Source="Nicolas_upshifts" /id="U1952" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.428571428571429" /psig=1 /xcortree=2760 /SigmaFactorBS="aaaaacgcaatccactaggctttCATTTACTtttattcattt tatGGGTATAATTTTATCTGCAGtaaagaaaatggcttgctggacagacagctgccat t" /listShort="S942, zur" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2261405..2261412) /Source="Nicolas_upshift_promotors" /id="U1952" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.428571428571429" /psig=1 /xcortree=2760 /SigmaFactorBS="aaaaacgcaatccactaggctttCATTTACTtttattcattt tatGGGTATAATTTTATCTGCAGtaaagaaaatggcttgctggacagacagctgccat t" /listShort="S942, zur" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2261418..2262299) /gene="yqfU" /locus_tag="BSU_25110" /old_locus_tag="BSU25110" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390390.2" /db_xref="EnsemblGenomes-Gn:BSU25110" /db_xref="EnsemblGenomes-Tr:CAB14441" /db_xref="GOA:P54478" /db_xref="InterPro:IPR003740" /db_xref="InterPro:IPR019264" /db_xref="SubtiList:BG11667" /db_xref="UniProtKB/Swiss-Prot:P54478" /translation="MTPTKQHKKETFTHFIFRVFMILVGAASAAVSIELFLIPNDFID GGIIGVSLILDHLFMSNPFLNFAFFVVILNIPFMIFGYKYIGKTFLVSTFIGIVGLAV IESSLHHVEAITTQPILATVFGGLLLGFGVGLVIRNGGSMDGTEILGILLTKKLPFSV GEFVMFINVFIFIWAVFVFGPEQAMYSFMTYYIAMKTIDAVIQGLDETKAVIIVSEQY DEISDAILHRLGRGTTKLKGKGGYTDEEKDVIYAVVTRLEVTKLKSIVFEVDQNAFIT IMNTHETRGGKFKNAIH*" /label="yqfU CDS" gene complement(2261418..2262299) /gene="yqfU" /locus_tag="BSU_25110" /old_locus_tag="BSU25110" /label="yqfU gene" promotor_-35 2262295..2262300 /Source="Nicolas_upshift_promotors" /id="U1953" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1102 /SigmaFactorBS="ctttcttatgttgttttgttgggGTCATAaaatctcctttcc tgCAATAACTATTTTAAATACattataaatctattttaccattaaacactgacacatt t" /listShort="yqfT, S944" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2262316..2262334 /Source="Nicolas_upshift_promotors" /id="U1953" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1102 /SigmaFactorBS="ctttcttatgttgttttgttgggGTCATAaaatctcctttcc tgCAATAACTATTTTAAATACattataaatctattttaccattaaacactgacacatt t" /listShort="yqfT, S944" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2262332 /Source="Nicolas_upshifts" /id="U1953" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1102 /SigmaFactorBS="ctttcttatgttgttttgttgggGTCATAaaatctcctttcc tgCAATAACTATTTTAAATACattataaatctattttaccattaaacactgacacatt t" /listShort="yqfT, S944" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(2262337..2262356) /Source="Nicolas_upshift_promotors" /id="U1954" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=2995 /SigmaFactorBS="cctccagacttaatgtatgggcaaatcagtaaaatgtgtcag tgtttAATGGTAAAATAGATTTATAatgtatttaaaatagttattgcaggaaaggaga t" /listShort="yqfU, S942, zur" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2262343) /Source="Nicolas_upshifts" /id="U1954" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=2995 /SigmaFactorBS="cctccagacttaatgtatgggcaaatcagtaaaatgtgtcag tgtttAATGGTAAAATAGATTTATAatgtatttaaaatagttattgcaggaaaggaga t" /listShort="yqfU, S942, zur" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2262345..2262672) /Source="Nicolas_S_feature" /locus_tag="new_2592930_2593257_c" /HighExp="Cold, T-4.40H, T-5.40H, Salt, GM-0.1, BMM, UNK1, MG 25, GM-0.2, SMM" /AntisenseName="yqfT" /AntisenseCor="-0.62379514374156597" /AntisenseRegPval="-29.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S943" promotor_-35 2262361..2262370 /Source="Nicolas_upshift_promotors" /id="U1955" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1273 /SigmaFactorBS="aataactattttaaatacattataaatctattttaccattaa acACTGACACATtttactgatttgCCCATACATTAAGTCTGGAGgtggaatgaccgat g" /listShort="yqfT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2262377 /Source="Nicolas_upshifts" /id="U1955" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1273 /SigmaFactorBS="aataactattttaaatacattataaatctattttaccattaa acACTGACACATtttactgatttgCCCATACATTAAGTCTGGAGgtggaatgaccgat g" /listShort="yqfT" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2262383..2262402 /Source="Nicolas_upshift_promotors" /id="U1955" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1273 /SigmaFactorBS="aataactattttaaatacattataaatctattttaccattaa acACTGACACATtttactgatttgCCCATACATTAAGTCTGGAGgtggaatgaccgat g" /listShort="yqfT" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2262415..2262669 /gene="yqfT" /locus_tag="BSU_25120" /old_locus_tag="BSU25120" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390391.1" /db_xref="EnsemblGenomes-Gn:BSU25120" /db_xref="EnsemblGenomes-Tr:CAB14442" /db_xref="InterPro:IPR020277" /db_xref="SubtiList:BG11666" /db_xref="UniProtKB/Swiss-Prot:P54477" /translation="MILFQRIILQRLNQATADDLLKYSKQYGISLTRSQAVEVANLLY GKNVNIFNESERMRLLKQVETITSKETAQTVNELFKQFTS*" /label="yqfT CDS" gene 2262415..2262669 /gene="yqfT" /locus_tag="BSU_25120" /old_locus_tag="BSU25120" /label="yqfT gene" downshifts 2262656 /Source="Nicolas_upshifts" /id="D1303" /incds=0 /nref=12 /ntot=72 /MaxReadThrough="3.97414" /MaxDrop="7.03976" /score="24.5413663" /energy="-9.8" /TU="U1953" /idTUdmin="U1955" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(2262696..2263589) /gene="nfo" /locus_tag="BSU_25130" /old_locus_tag="BSU25130" /EC_number="3.1.21.2" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12486072, 12949090, 16237020, 18203828, 19930460, 21441501, 24123749, 24244006, 24914186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12486072, 12949090, 16237020, 18203828, 19930460, 21441501, 24123749, 24244006, 24914186; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="type IV apurinic/apyrimidinic endonuclease" /protein_id="NP_390392.1" /db_xref="EnsemblGenomes-Gn:BSU25130" /db_xref="EnsemblGenomes-Tr:CAB14443" /db_xref="GOA:P54476" /db_xref="InterPro:IPR001719" /db_xref="InterPro:IPR013022" /db_xref="InterPro:IPR018246" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG11665" /db_xref="UniProtKB/Swiss-Prot:P54476" /translation="MLRIGSHVSMSGKHMLLAASQEAVSYGANTFMIYTGAPQNTRRK KIEDLNIEAGRAHMQENGIDEIIVHAPYIINIGNTTNPSTFELGVDFLRSEIERTAAI GAKQIVLHPGAHVGAGAEAGIKKIIEGLNEVIDPNQNVQIALETMAGKGSECGRSFEE LAQIIEGVTHNEQLSVCFDTCHTHDAGYNIVEDFDGVLNEFDKIIGIDRIKVLHINDS KNVKGARKDRHENIGFGEIGFDALQYVVHHEQLKDIPKILETPYVGEDKKNKKPPYRF EIEMLKEKQFDDTLLEKILQQ*" /label="nfo CDS" gene complement(2262696..2263589) /gene="nfo" /locus_tag="BSU_25130" /old_locus_tag="BSU25130" /label="nfo gene" S_feature 2262701..2263502 /Source="Nicolas_S_feature" /locus_tag="new_2593286_2594087" /HighExp="S6, S7, C30, S8, S5, G135, C90, Gly, LoTm, Sw" /AntisenseName="nfo" /AntisenseCor="-0.36683479556464399" /AntisenseRegPval="-9.3000000000000007" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.948" /TUlongSig="NA" /TUlongPSig="NA" /label="S944" downshifts complement(2262717) /Source="Nicolas_upshifts" /id="D1304" /incds=0 /nref=46 /ntot=187 /MaxReadThrough="4.82641" /MaxDrop="6.05328" /score="16.7756411" /energy="-9.8" /TU="U1956" /idTUdmin="U1952" /TUdmin="-1870" /isTUend="FALSE" /label="downshifts" CDS complement(2263599..2264915) /gene="cshB" /locus_tag="BSU_25140" /old_locus_tag="BSU25140" /EC_number="3.6.1.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16014871, 16352840, 18203828, 20572937, 23175651" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16014871, 16352840, 18203828, 20572937, 23175651; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent RNA helicase; cold shock" /protein_id="NP_390393.1" /db_xref="EnsemblGenomes-Gn:BSU25140" /db_xref="EnsemblGenomes-Tr:CAB14444" /db_xref="GOA:P54475" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR014014" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030881" /db_xref="SubtiList:BG11664" /db_xref="UniProtKB/Swiss-Prot:P54475" /translation="MKETKFELYELKPFIIDAVHRLGFYEPTDIQKRLIPAVLKKESV IGQSQTGTGKTHAYLLPLLNKIDPAKDVVQVVITAPTRELANQIYQEALKITQGEEGS QIRSKCFIGGTDKQKSIDKLKIQPHLVVGTPGRIADLIKEQALSVHKAESLVIDEADL MLDMGFLADVDYIGSRMPEDLQMLVFSATIPEKLKPFLKKYMENPKYAHVEPKQVTAA KIEHILIPSKHRDKDKLLFDIMSHLNPYLGIVFANTKNTADHIAQYLTGKGMKIGLLH GGLTPRERKKVMKQINDLEFTYIIATDLAARGIDIKGVSHVINYELPDDLDFYVHRVG RTARAGSSGQAMTIYELTDEDALVRLEKMGIEFEYLELEKGEWKKGDDRQRRKKRKKT PNEADEIAHRLVKKPKKVKPGYKKKMSYEMEKIKKKQRRNQSKKRK*" /label="cshB CDS" gene complement(2263599..2264915) /gene="cshB" /locus_tag="BSU_25140" /old_locus_tag="BSU25140" /label="cshB gene" promotor_-10 complement(2264951..2264970) /Source="Nicolas_upshift_promotors" /id="U1956" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.683316683316683" /psig=1 /xcortree=2492 /SigmaFactorBS="tacataactgaataaaacaaacgccttgcaaaCGTGGtgttt ttaagcaaaaTCGGGTATAATGTGATGATGgacacataatgtgccgctttaaggagct g" /listShort="cshB, nfo, S943, yqfU, S942, zur" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2264962) /Source="Nicolas_upshifts" /id="U1956" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.683316683316683" /psig=1 /xcortree=2492 /SigmaFactorBS="tacataactgaataaaacaaacgccttgcaaaCGTGGtgttt ttaagcaaaaTCGGGTATAATGTGATGATGgacacataatgtgccgctttaaggagct g" /listShort="cshB, nfo, S943, yqfU, S942, zur" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2264986..2264990) /Source="Nicolas_upshift_promotors" /id="U1956" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.683316683316683" /psig=1 /xcortree=2492 /SigmaFactorBS="tacataactgaataaaacaaacgccttgcaaaCGTGGtgttt ttaagcaaaaTCGGGTATAATGTGATGATGgacacataatgtgccgctttaaggagct g" /listShort="cshB, nfo, S943, yqfU, S942, zur" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2265019..2265028 /Source="Nicolas_upshift_promotors" /id="U1957" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1300 /SigmaFactorBS="aaaacaccacgtttgcaaggcgtttgttttattcagttaTGT AAAGCAAataccgcagcccaTGCATATTCTAATAGCAGAGagagctgaaaggaggtac a" /listShort="yqfQ, S945, ispH" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2265040 /Source="Nicolas_upshifts" /id="U1957" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1300 /SigmaFactorBS="aaaacaccacgtttgcaaggcgtttgttttattcagttaTGT AAAGCAAataccgcagcccaTGCATATTCTAATAGCAGAGagagctgaaaggaggtac a" /listShort="yqfQ, S945, ispH" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2265042..2265061 /Source="Nicolas_upshift_promotors" /id="U1957" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1300 /SigmaFactorBS="aaaacaccacgtttgcaaggcgtttgttttattcagttaTGT AAAGCAAataccgcagcccaTGCATATTCTAATAGCAGAGagagctgaaaggaggtac a" /listShort="yqfQ, S945, ispH" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2265084..2265827 /gene="yqfQ" /locus_tag="BSU_25150" /old_locus_tag="BSU25150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390394.1" /db_xref="EnsemblGenomes-Gn:BSU25150" /db_xref="EnsemblGenomes-Tr:CAB14445" /db_xref="InterPro:IPR025571" /db_xref="SubtiList:BG11663" /db_xref="UniProtKB/Swiss-Prot:P54474" /translation="MFSPQQPMRNYPQPGPPRPMPNQRMMGRRPPNMRGPSFGAQQQG FQQAGQFLPQANAGARNGAGAGGGLKGMLSRFLPGGGGAGSAGVPGIPGAGAAASGGA GLQGIQNIANPASLSSMLGNVQKVLGMAQQVTPMIQQYGPLVRNLPAMMKLYSQLSKS DDTETEANEESEKQSVSEESSEKEKETETKTSDGNKKSKPKSSSLPKKSKTTDNKEQE LKTSAPKKKEAASPAPKRTSGSSKPRLYI*" /label="yqfQ CDS" gene 2265084..2265827 /gene="yqfQ" /locus_tag="BSU_25150" /old_locus_tag="BSU25150" /label="yqfQ gene" downshifts 2265809 /Source="Nicolas_upshifts" /id="D1305" /incds=0 /nref=1 /ntot=27 /MaxReadThrough="5.46594" /MaxDrop="3.2445" /score="4.32537428" /energy="-6.8" /TU="U1957" /idTUdmin="U1957" /TUdmin="-1056" /isTUend="FALSE" /label="downshifts" promotor_-35 2265831..2265838 /Source="Nicolas_upshift_promotors" /id="U1958" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig=1 /xcortree=2580 /SigmaFactorBS="atcaggcagttcaaaaccgagattatatatttaacatTCTTT GATatcttaagtgagaTTGGCTATAATGAGATCAGAagaatgcaagaatagagccgtt t" /listShort="S945, ispH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2265852..2265871 /Source="Nicolas_upshift_promotors" /id="U1958" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig=1 /xcortree=2580 /SigmaFactorBS="atcaggcagttcaaaaccgagattatatatttaacatTCTTT GATatcttaagtgagaTTGGCTATAATGAGATCAGAagaatgcaagaatagagccgtt t" /listShort="S945, ispH" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2265854..2265949 /Source="Nicolas_S_feature" /locus_tag="new_2596439_2596534" /HighExp="S8, S7, S6, Cold, H2O2, Salt, dia15, G180, Paraq, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S945" upshifts 2265854 /Source="Nicolas_upshifts" /id="U1958" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig=1 /xcortree=2580 /SigmaFactorBS="atcaggcagttcaaaaccgagattatatatttaacatTCTTT GATatcttaagtgagaTTGGCTATAATGAGATCAGAagaatgcaagaatagagccgtt t" /listShort="S945, ispH" /GFF_Attribute="listLong" /label="upshifts" CDS 2265950..2266894 /gene="ispH" /locus_tag="BSU_25160" /old_locus_tag="BSU25160" /EC_number="1.17.7.4" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 12706830, 15381396, 15469281, 17458547, 27169371; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase" /protein_id="NP_390395.2" /db_xref="EnsemblGenomes-Gn:BSU25160" /db_xref="EnsemblGenomes-Tr:CAB14446" /db_xref="GOA:P54473" /db_xref="InterPro:IPR003451" /db_xref="SubtiList:BG11662" /db_xref="UniProtKB/Swiss-Prot:P54473" /translation="MDVIKISPRGYCYGVVDAMVIAKNASLDKSLPRPIYILGMIVHN KHVTDAFEEEGIFTLDGSNRLDILKQVDKGTVIFTAHGVSPEVRRIAEEKGLVAIDAT CPDVTKTHNLILEMKEKGYHVIYIGKKGHPEPEGAVGVAPEIVHLVETEEDVKNLDIQ SEKLIVTNQTTMSQWDVHDIMELVKEKYPHVEYHQEICLATQVRQEAVSEQAKKADLT IVVGDPKSNNSNRLAQVSEEIAGTKAYRIGDLSELKLEWLKGVNTVAVTAGASTPTPI TKEVIRFLEQFDHEDPSTWTTEHNIPLKKILPKVKAKN*" /label="ispH CDS" gene 2265950..2266894 /gene="ispH" /locus_tag="BSU_25160" /old_locus_tag="BSU25160" /label="ispH gene" downshifts 2266865 /Source="Nicolas_upshifts" /id="D1306" /incds=0 /nref=106 /ntot=243 /MaxReadThrough="4.04288" /MaxDrop="5.66904" /score="29.529951" /energy="-12.2" /TU="U1958" /idTUdmin="U1957" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2266917..2268038) /gene="yqfO" /locus_tag="BSU_25170" /old_locus_tag="BSU25170" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17187687, 17586767; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative GTP cyclohydrolase" /protein_id="NP_390396.1" /db_xref="EnsemblGenomes-Gn:BSU25170" /db_xref="EnsemblGenomes-Tr:CAB14447" /db_xref="GOA:P54472" /db_xref="InterPro:IPR002678" /db_xref="InterPro:IPR015867" /db_xref="InterPro:IPR017221" /db_xref="InterPro:IPR036069" /db_xref="SubtiList:BG11661" /db_xref="UniProtKB/Swiss-Prot:P54472" /translation="MAKSVNGQQIIQLFEQFSPKAYAVEGDKIGLQIGTLNKPIKNVM VTLDVLESVIDEAIEKEVDLIIAHHPPIFRSLKHISTDQPAGRLIEKCLKHDIAVYAA HTNLDVADGGVNDLLAEALELSETEVLAPTYTDPLKKLAVYVPKEYEEQVRAALGNAG AGHIGEYSHCAFSSEGIGSFKPLDGAKPFIGEVGELELVHEVRLETVFPKSVEKAVIN AMIKSHPYEEVAYDIYPVEQTPAEKGLGRVGTLKNEMTLKEFALFVKDKLDVNGVRMV GDADSMVKKVAVLGGDGNKYIHHAKRKGADVYVTGDLYFHVAHDAMMLGLNVVDPGHY AEKIMKEGVTRKLTSMCNDKKFGVNIFVSETDTNPFTFL*" /label="yqfO CDS" gene complement(2266917..2268038) /gene="yqfO" /locus_tag="BSU_25170" /old_locus_tag="BSU25170" /label="yqfO gene" downshifts complement(2266942) /Source="Nicolas_upshifts" /id="D1307" /incds=0 /nref=63 /ntot=224 /MaxReadThrough="3.241" /MaxDrop="4.76436" /score="27.9821938" /energy="-12.2" /TU="NA" /idTUdmin="U1959" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2268031..2268681) /gene="trmK" /locus_tag="BSU_25180" /old_locus_tag="BSU25180" /EC_number="2.1.1.217" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:18420655, 27098549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18420655, 27098549; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA (adenine(22)-N(1))-methyltransferase" /protein_id="NP_390397.1" /db_xref="EnsemblGenomes-Gn:BSU25180" /db_xref="EnsemblGenomes-Tr:CAB14448" /db_xref="GOA:P54471" /db_xref="InterPro:IPR006901" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11660" /db_xref="UniProtKB/Swiss-Prot:P54471" /translation="MADIGSDHAYLPCYAVLNHKASGAIAGEITDGPFLSAKRQVEKS GLNSHISVRQGDGLEVIKKGEADAITIAGMGGALIAHILEAGKDKLTGKERLILQPNI HAVHIREWLYKERYALIDEVILEEDGKCYEVLVAEAGDRDAAYDGISLSAGMLVGPFL AKEKNAVFLKKWTQELQHTQSIYEQISQAADTEQNKQKLKELADRMELLKEVIDHG*" /label="trmK CDS" gene complement(2268031..2268681) /gene="trmK" /locus_tag="BSU_25180" /old_locus_tag="BSU25180" /label="trmK gene" S_feature complement(2268682..2268790) /Source="Nicolas_S_feature" /locus_tag="new_2599267_2599375_c" /HighExp="LBGexp, LBGtran, dia15, dia0, Lbexp, G150, G180, LBGstat, Oxctl, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 0.98, 0.998" /TUlongSig="SigH, SigEF, SigA, SigA, SigA, SigA, SigA" /TUlongPSig="1, 0.974, 0.979, 1, 1, 0.999, 0.998" /label="S946" promotor_-10 complement(2268778..2268797) /Source="Nicolas_upshift_promotors" /id="U1959" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig=1 /xcortree=2573 /SigmaFactorBS="tcaaaagaaataatttcaaaatcatttgcttcaGCTTGgatt ccgggctgattTTTTATATGATAGTAAAGGAaaaaatgattgagaaaagttgtgatga c" /listShort="S946, trmK, yqfO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2268790) /Source="Nicolas_upshifts" /id="U1959" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig=1 /xcortree=2573 /SigmaFactorBS="tcaaaagaaataatttcaaaatcatttgcttcaGCTTGgatt ccgggctgattTTTTATATGATAGTAAAGGAaaaaatgattgagaaaagttgtgatga c" /listShort="S946, trmK, yqfO" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2268792..2268905) /Source="Nicolas_S_feature" /locus_tag="new_2599377_2599490_c" /HighExp="Lbstat, M0t90, M9-stat, S2, T1.0H, T1.30H, T2.30H, T3.0H, S7, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.98, 0.998" /TUlongSig="SigH, SigEF, SigA, SigA, SigA, SigA, SigA" /TUlongPSig="1, 0.974, 0.979, 1, 1, 0.999, 0.998" /label="S947" promotor_-35 complement(2268813..2268817) /Source="Nicolas_upshift_promotors" /id="U1959" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig=1 /xcortree=2573 /SigmaFactorBS="tcaaaagaaataatttcaaaatcatttgcttcaGCTTGgatt ccgggctgattTTTTATATGATAGTAAAGGAaaaaatgattgagaaaagttgtgatga c" /listShort="S946, trmK, yqfO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2268938..2269300) /gene="cccA" /locus_tag="BSU_25190" /old_locus_tag="BSU25190" /function="16.7: Manage energy" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10024472, 10473570, 11361075, 15995641, 19222757" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10024472, 10473570, 11361075, 15995641, 19222757; Product type c: carrier" /codon_start=1 /transl_table=11 /product="cytochrome c550" /protein_id="NP_390398.1" /db_xref="EnsemblGenomes-Gn:BSU25190" /db_xref="EnsemblGenomes-Tr:CAB14449" /db_xref="GOA:P24469" /db_xref="InterPro:IPR009056" /db_xref="InterPro:IPR012218" /db_xref="InterPro:IPR036909" /db_xref="SubtiList:BG10315" /db_xref="UniProtKB/Swiss-Prot:P24469" /translation="MKWNPLIPFLLIAVLGIGLTFFLSVKGLDDSREIASGGESKSAE KKDANASPEEIYKANCIACHGENYEGVSGPSLKGVGDKKDVAEIKTKIEKGGNGMPSG LVPADKLDDMAEWVSKIK*" /label="cccA CDS" gene complement(2268938..2269300) /gene="cccA" /locus_tag="BSU_25190" /old_locus_tag="BSU25190" /label="cccA gene" downshifts complement(2268950) /Source="Nicolas_upshifts" /id="D1308" /incds=0 /nref=3 /ntot=88 /MaxReadThrough="4.32389" /MaxDrop="3.4795" /score="-4.13120914" /energy="-7.6" /TU="U1961,U1962" /idTUdmin="U1968" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" promotor_-35 2269296..2269300 /Source="Nicolas_upshift_promotors" /id="U1960" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=693 /SigmaFactorBS="agcaaaaatggaataagcgggttccatTTCATttcccttCCC CCTTTTTGATCCttccccctatgtaaacacttctaattctaacttatttttacaaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2269308..2269322 /Source="Nicolas_upshift_promotors" /id="U1960" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=693 /SigmaFactorBS="agcaaaaatggaataagcgggttccatTTCATttcccttCCC CCTTTTTGATCCttccccctatgtaaacacttctaattctaacttatttttacaaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2269329 /Source="Nicolas_upshifts" /id="U1960" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=693 /SigmaFactorBS="agcaaaaatggaataagcgggttccatTTCATttcccttCCC CCTTTTTGATCCttccccctatgtaaacacttctaattctaacttatttttacaaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2269337..2269356) /Source="Nicolas_upshift_promotors" /id="U1961" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.274725274725275" /psig="0.98001998001998" /xcortree=484 /SigmaFactorBS="ataaaaaacttttgtatagcaatcCATTTACTttttgtaaaa aTAAGTTAGAATTAGAAGTGTttacatagggggaaggatcaaaaagggggaagggaaa t" /listShort="cccA, S947, S946, trmK, yqfO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2269339) /Source="Nicolas_upshifts" /id="U1961" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.274725274725275" /psig="0.98001998001998" /xcortree=484 /SigmaFactorBS="ataaaaaacttttgtatagcaatcCATTTACTttttgtaaaa aTAAGTTAGAATTAGAAGTGTttacatagggggaaggatcaaaaagggggaagggaaa t" /listShort="cccA, S947, S946, trmK, yqfO" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2269341..2269462) /Source="Nicolas_S_feature" /locus_tag="new_2599926_2600047_c" /HighExp="Lbstat, T3.0H, T1.30H, M9-stat, T2.30H, T1.0H, T2.0H, T3.30H, M0t90, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH, SigEF, SigA, SigA, SigA, SigA" /TUshortPSig="0.998, 1, 0.974, 0.979, 1, 1, 0.999" /TUlongSig="SigA, SigGF" /TUlongPSig="0.998, 0.979" /label="S948" promotor_-35 complement(2269368..2269375) /Source="Nicolas_upshift_promotors" /id="U1961" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.274725274725275" /psig="0.98001998001998" /xcortree=484 /SigmaFactorBS="ataaaaaacttttgtatagcaatcCATTTACTttttgtaaaa aTAAGTTAGAATTAGAAGTGTttacatagggggaaggatcaaaaagggggaagggaaa t" /listShort="cccA, S947, S946, trmK, yqfO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2269451..2269470) /Source="Nicolas_upshift_promotors" /id="U1962" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.42957042957043" /psig="0.998001998001998" /xcortree=363 /SigmaFactorBS="tgaaaaatttcaaaatctaattccatattttcTATTGTAagc gtatacaataCATTATACAATAGAATAAAAaggatattagagatttaggcatgtttct a" /listShort="S948, cccA, S947, S946, trmK, yqfO" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2269459..2269478 /Source="Nicolas_upshift_promotors" /id="U1963" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.485514485514486" /psig="0.997002997002997" /xcortree=360 /SigmaFactorBS="ctttatacaaaattgaatagaaacatgcctaaatctcTaata tcctttttattcTATTGTATAATGTATTGTATacgcttacaatagaaaatatggaatt a" /listShort="S950, S951" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2269462) /Source="Nicolas_upshifts" /id="U1962" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.42957042957043" /psig="0.998001998001998" /xcortree=363 /SigmaFactorBS="tgaaaaatttcaaaatctaattccatattttcTATTGTAagc gtatacaataCATTATACAATAGAATAAAAaggatattagagatttaggcatgtttct a" /listShort="S948, cccA, S947, S946, trmK, yqfO" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2269464..2269603) /Source="Nicolas_S_feature" /locus_tag="new_2600049_2600188_c" /HighExp="Lbstat, S8, S1, S7, G/S, BT, Mal, Gly, S6, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH, SigEF, SigA, SigA, SigA, SigA" /TUshortPSig="1, 0.974, 0.979, 1, 1, 0.999" /TUlongSig="SigA, SigGF" /TUlongPSig="0.998, 0.979" /label="S949" S_feature 2269465..2269569 /Source="Nicolas_S_feature" /locus_tag="new_2600050_2600154" /HighExp="T2.30H, M9-stat, T3.0H, T1.30H, T2.0H, T1.0H, T3.30H, T4.0H, M0t90, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S950" upshifts 2269465 /Source="Nicolas_upshifts" /id="U1963" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.485514485514486" /psig="0.997002997002997" /xcortree=360 /SigmaFactorBS="ctttatacaaaattgaatagaaacatgcctaaatctcTaata tcctttttattcTATTGTATAATGTATTGTATacgcttacaatagaaaatatggaatt a" /listShort="S950, S951" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2269484..2269490) /Source="Nicolas_upshift_promotors" /id="U1962" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.42957042957043" /psig="0.998001998001998" /xcortree=363 /SigmaFactorBS="tgaaaaatttcaaaatctaattccatattttcTATTGTAagc gtatacaataCATTATACAATAGAATAAAAaggatattagagatttaggcatgtttct a" /listShort="S948, cccA, S947, S946, trmK, yqfO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2269533..2269540 /Source="Nicolas_upshift_promotors" /id="U1964" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=558 /SigmaFactorBS="tgaaatttttcaccacaatgttCATTTGCAaatgacatcatt tTTCAGTAAAATAAAGGCATAttatccatatatctttttaaaaaaagaagaacggatc t" /listShort="S951" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2269554..2269573 /Source="Nicolas_upshift_promotors" /id="U1964" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=558 /SigmaFactorBS="tgaaatttttcaccacaatgttCATTTGCAaatgacatcatt tTTCAGTAAAATAAAGGCATAttatccatatatctttttaaaaaaagaagaacggatc t" /listShort="S951" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2269571..2271720 /Source="Nicolas_S_feature" /locus_tag="new_2600156_2602305" /HighExp="S2, T4.0H, T5.0H, Lbstat, M9-stat, T3.30H, S8, T3.0H, C30, T2.0H" /AntisenseName="sigA" /AntisenseCor="-0.16938350693676901" /AntisenseRegPval="-2.2999999999999998" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S951" upshifts 2269571 /Source="Nicolas_upshifts" /id="U1964" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=558 /SigmaFactorBS="tgaaatttttcaccacaatgttCATTTGCAaatgacatcatt tTTCAGTAAAATAAAGGCATAttatccatatatctttttaaaaaaagaagaacggatc t" /listShort="S951" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2269629..2270744) /gene="sigA" /locus_tag="BSU_25200" /old_locus_tag="BSU25200" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12455702, 12682299, 14527287, 15060039, 15670950, 28648455" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12455702, 12682299, 14527287, 15060039, 15670950, 28648455; Product type f : factor" /codon_start=1 /transl_table=11 /product="RNA polymerase major sigma-43 factor (sigma-A)" /protein_id="NP_390399.2" /db_xref="EnsemblGenomes-Gn:BSU25200" /db_xref="EnsemblGenomes-Tr:CAB14450" /db_xref="GOA:P06224" /db_xref="InterPro:IPR000943" /db_xref="InterPro:IPR007127" /db_xref="InterPro:IPR007624" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR007630" /db_xref="InterPro:IPR009042" /db_xref="InterPro:IPR012760" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR028630" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10314" /db_xref="UniProtKB/Swiss-Prot:P06224" /translation="MADKQTHETELTFDQVKEQLTESGKKRGVLTYEEIAERMSSFEI ESDQMDEYYEFLGEQGVELISENEETEDPNIQQLAKAEEEFDLNDLSVPPGVKINDPV RMYLKEIGRVNLLSAKEEIAYAQKIEEGDEESKRRLAEANLRLVVSIAKRYVGRGMLF LDLIQEGNMGLMKAVEKFDYRKGYKFSTYATWWIRQAITRAIADQARTIRIPVHMVET INKLIRVQRQLLQDLGREPTPEEIAEDMDLTPEKVREILKIAQEPVSLETPIGEEDDS HLGDFIEDQEATSPSDHAAYELLKEQLEDVLDTLTDREENVLRLRFGLDDGRTRTLEE VGKVFGVTRERIRQIEAKALRKLRHPSRSKRLKDFLE*" /label="sigA CDS" gene complement(2269629..2270744) /gene="sigA" /locus_tag="BSU_25200" /old_locus_tag="BSU25200" /label="sigA gene" downshifts complement(2269648) /Source="Nicolas_upshifts" /id="D1309" /incds=0 /nref=118 /ntot=198 /MaxReadThrough="4.93947" /MaxDrop="6.16048" /score="4.75833607" /energy="-11.7" /TU="U1966,U1968,U1969,U1970,U1972,U1973" /idTUdmin="U1970" /TUdmin="-287" /isTUend="FALSE" /label="downshifts" S_feature complement(2270745..2270942) /Source="Nicolas_S_feature" /locus_tag="new_2601330_2601527_c" /HighExp="BC, Cold, SMMPr, S1, BI, G135, C30, Lbstat, S5, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH, SigEF, SigA, SigA, SigA, SigA" /TUshortPSig="1, 0.974, 0.979, 1, 1, 0.999" /TUlongSig="SigA, SigGF" /TUlongPSig="0.998, 0.979" /label="S952" CDS complement(2270943..2272754) /gene="dnaG" /locus_tag="BSU_25210" /old_locus_tag="BSU25210" /EC_number="2.7.7.-" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 3100394, 9387153, 12682299, 16036556, 28386108; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA primase" /protein_id="NP_390400.2" /db_xref="EnsemblGenomes-Gn:BSU25210" /db_xref="EnsemblGenomes-Tr:CAB14451" /db_xref="GOA:P05096" /db_xref="InterPro:IPR002694" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR006295" /db_xref="InterPro:IPR013264" /db_xref="InterPro:IPR016136" /db_xref="InterPro:IPR019475" /db_xref="InterPro:IPR030846" /db_xref="InterPro:IPR034151" /db_xref="InterPro:IPR036185" /db_xref="InterPro:IPR036977" /db_xref="InterPro:IPR037068" /db_xref="PDB:5GUJ" /db_xref="SubtiList:BG10313" /db_xref="UniProtKB/Swiss-Prot:P05096" /translation="MGNRIPDEIVDQVQKSADIVEVIGDYVQLKKQGRNYFGLCPFHG ESTPSFSVSPDKQIFHCFGCGAGGNVFSFLRQMEGYSFAESVSHLADKYQIDFPDDIT VHSGARPESSGEQKMAEAHELLKKFYHHLLINTKEGQEALDYLLSRGFTKELINEFQI GYALDSWDFITKFLVKRGFSEAQMEKAGLLIRREDGSGYFDRFRNRVMFPIHDHHGAV VAFSGRALGSQQPKYMNSPETPLFHKSKLLYNFYKARLHIRKQERAVLFEGFADVISA VSSDVKESIATMGTSLTDDHVKILRRNVEEIILCYDSDKAGYEATLKASELLQKKGCK VRVAMIPDGLDPDDYIKKFGGEKFKNDIIDASVTVMAFKMQYFRKGKNLSDEGDRLAY IKDVLKEISTLSGSLEQEVYVKQLASEFSLSQESLTEQLSVFSKQNKPADNSGETKTR RAHLTTKARQKRLRPAYENAERLLLAHMLRDRSVIKKVIDRVGFQFNIDEHRALAAYL YAFYEEGAELTPQHLMARVTDDHISQLLSDILMLQVNQELSEAELSDYVKKVLNQRNW SMIKEKEAERAEAERQKDFLRAASLAQEIVTLNRSLK*" /label="dnaG CDS" gene complement(2270943..2272754) /gene="dnaG" /locus_tag="BSU_25210" /old_locus_tag="BSU25210" /label="dnaG gene" promotor_-35 2272349..2272355 /Source="Nicolas_upshift_promotors" /id="U1965" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.738261738261738" /psig="0.998001998001998" /xcortree=455 /SigmaFactorBS="aaagcccctagaaagcagataatccagtgcctcttgaccttc ttTTGTATTtattaacaaatGATGGTAAAATTTCTTCAGGagctcatgtgcctcagcc a" /listShort="antE" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2272365 /Source="Nicolas_upshifts" /id="U1965" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.738261738261738" /psig="0.998001998001998" /xcortree=455 /SigmaFactorBS="aaagcccctagaaagcagataatccagtgcctcttgaccttc ttTTGTATTtattaacaaatGATGGTAAAATTTCTTCAGGagctcatgtgcctcagcc a" /listShort="antE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2272367..2272386 /Source="Nicolas_upshift_promotors" /id="U1965" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.738261738261738" /psig="0.998001998001998" /xcortree=455 /SigmaFactorBS="aaagcccctagaaagcagataatccagtgcctcttgaccttc ttTTGTATTtattaacaaatGATGGTAAAATTTCTTCAGGagctcatgtgcctcagcc a" /listShort="antE" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2272394..2272690 /gene="antE" /locus_tag="BSU_25220" /old_locus_tag="BSU25220" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId: 9864351" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_054587.1" /db_xref="EnsemblGenomes-Gn:BSU25220" /db_xref="EnsemblGenomes-Tr:CAE01462" /db_xref="GOA:Q7WY63" /db_xref="SubtiList:BG14178" /db_xref="UniProtKB/Swiss-Prot:Q7WY63" /translation="MPQPFFVLQKTLAGLRNGLLYHLENQFGICQQGEKPTRQKNSLP SALKKRKHCRPLRSQSNEKSVCRAIRKTKVCFLHEKDRVQSSFGLASLIEHNHL*" /label="antE CDS" gene 2272394..2272690 /gene="antE" /locus_tag="BSU_25220" /old_locus_tag="BSU25220" /label="antE gene" CDS complement(2272788..2273282) /gene="yqxD" /locus_tag="BSU_25230" /old_locus_tag="BSU25230" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 9387153, 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390401.2" /db_xref="EnsemblGenomes-Gn:BSU25230" /db_xref="EnsemblGenomes-Tr:CAB14452" /db_xref="InterPro:IPR003791" /db_xref="SubtiList:BG10312" /db_xref="UniProtKB/Swiss-Prot:P17868" /translation="MEGWRITLLNEQEKTIFVDADACPVKDEILQTASEYEVQVLFVA SFEHYQLSRSNEEKWKYVDPHKEAADLYIANHVKPGDIVVTQDIGLASLLLNRNVSVM SERGRLYKEDTIDFALEGRHFSGKQRRKGVYAKGPKKLNKEDRERFITLLQKILSNDE GILH*" /label="yqxD CDS" gene complement(2272788..2273282) /gene="yqxD" /locus_tag="BSU_25230" /old_locus_tag="BSU25230" /label="yqxD gene" promotor_-10 complement(2273255..2273273) /Source="Nicolas_upshift_promotors" /id="U1966" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=431 /SigmaFactorBS="taataaaggatgtgcgattttgcttgcttttatGCAGGAGTT taatggagggaTGGAGAATTACTCTTCTTAatgaacaagaaaagacgatttttgtcga t" /listShort="yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-10" upshifts complement(2273266) /Source="Nicolas_upshifts" /id="U1966" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=431 /SigmaFactorBS="taataaaggatgtgcgattttgcttgcttttatGCAGGAGTT taatggagggaTGGAGAATTACTCTTCTTAatgaacaagaaaagacgatttttgtcga t" /listShort="yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="upshifts" S_feature complement(2273283..2273396) /Source="Nicolas_S_feature" /locus_tag="new_2603868_2603981_c" /HighExp="S5, S4, S6, S7, S8, S3, Etha, dia15, G180, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA, SigA, SigA, SigA" /TUshortPSig="0.974, 0.979, 1, 1, 0.999" /TUlongSig="SigA, SigGF" /TUlongPSig="0.998, 0.979" /label="S953" promotor_-35 complement(2273285..2273293) /Source="Nicolas_upshift_promotors" /id="U1966" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=431 /SigmaFactorBS="taataaaggatgtgcgattttgcttgcttttatGCAGGAGTT taatggagggaTGGAGAATTACTCTTCTTAatgaacaagaaaagacgatttttgtcga t" /listShort="yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-35" promotor_-35 2273291..2273296 /Source="Nicolas_upshift_promotors" /id="U1967" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.832167832167832" /psig="0.832167832167832" /xcortree=1219 /SigmaFactorBS="ttctccatccctccattaaactccTGCATAaaagcaagcaaa atcGCACATCCTTTATTATTGTggatgtatatgaatttgtcgaaaaatttccgggaga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2273312..2273330 /Source="Nicolas_upshift_promotors" /id="U1967" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.832167832167832" /psig="0.832167832167832" /xcortree=1219 /SigmaFactorBS="ttctccatccctccattaaactccTGCATAaaagcaagcaaa atcGCACATCCTTTATTATTGTggatgtatatgaatttgtcgaaaaatttccgggaga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2273327 /Source="Nicolas_upshifts" /id="U1967" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.832167832167832" /psig="0.832167832167832" /xcortree=1219 /SigmaFactorBS="ttctccatccctccattaaactccTGCATAaaagcaagcaaa atcGCACATCCTTTATTATTGTggatgtatatgaatttgtcgaaaaatttccgggaga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2273381..2273399) /Source="Nicolas_upshift_promotors" /id="U1968" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=794 /SigmaFactorBS="ttataataaaaaattgtgataaaatgattaattttaGGTTTA aggatcgtgtgatacGAATAAACTATTATGGGTAagatgtcaagaatttctcccggaa a" /listShort="S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-10" upshifts complement(2273396) /Source="Nicolas_upshifts" /id="U1968" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=794 /SigmaFactorBS="ttataataaaaaattgtgataaaatgattaattttaGGTTTA aggatcgtgtgatacGAATAAACTATTATGGGTAagatgtcaagaatttctcccggaa a" /listShort="S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="upshifts" S_feature complement(2273398..2273475) /Source="Nicolas_S_feature" /locus_tag="new_2603983_2604060_c" /HighExp="Etha, G180, G135, G150, LBGtran, LBGexp, dia15, H2O2, Oxctl, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="0.979, 1, 1, 0.999" /TUlongSig="SigA, SigGF" /TUlongPSig="0.998, 0.979" /label="S954" promotor_-35 complement(2273415..2273420) /Source="Nicolas_upshift_promotors" /id="U1968" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=794 /SigmaFactorBS="ttataataaaaaattgtgataaaatgattaattttaGGTTTA aggatcgtgtgatacGAATAAACTATTATGGGTAagatgtcaagaatttctcccggaa a" /listShort="S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-35" promotor_-10 complement(2273441..2273460) /Source="Nicolas_upshift_promotors" /id="U1969" /multdbtbs="SigA,SigA" /comp="M16" /sig="SigA" /pcomp="0.731268731268731" /psig="0.97902097902098" /xcortree=2530 /SigmaFactorBS="ctcaggacgctctatcctgggtttttggctgtgccaaaaggg aataatgaaaaacaATAGcatctttgtgaagttTGTATTATAATAAAAAATTGtgata a" /listShort="S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-10" upshifts complement(2273475) /Source="Nicolas_upshifts" /id="U1969" /multdbtbs="SigA,SigA" /comp="M16" /sig="SigA" /pcomp="0.731268731268731" /psig="0.97902097902098" /xcortree=2530 /SigmaFactorBS="ctcaggacgctctatcctgggtttttggctgtgccaaaaggg aataatgaaaaacaATAGcatctttgtgaagttTGTATTATAATAAAAAATTGtgata a" /listShort="S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="upshifts" promotor_-35 complement(2273476..2273479) /Source="Nicolas_upshift_promotors" /id="U1969" /multdbtbs="SigA,SigA" /comp="M16" /sig="SigA" /pcomp="0.731268731268731" /psig="0.97902097902098" /xcortree=2530 /SigmaFactorBS="ctcaggacgctctatcctgggtttttggctgtgccaaaaggg aataatgaaaaacaATAGcatctttgtgaagttTGTATTATAATAAAAAATTGtgata a" /listShort="S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-35" CDS complement(2273536..2274348) /gene="ppsR" /locus_tag="BSU_25240" /old_locus_tag="BSU25240" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15720552, 20044937" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15720552, 20044937; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional ADP-dependent kinase-Pi-dependent pyrophosphorylase / positive regulator of gluconeogenesis" /protein_id="NP_390402.1" /db_xref="EnsemblGenomes-Gn:BSU25240" /db_xref="EnsemblGenomes-Tr:CAB14453" /db_xref="GOA:P54470" /db_xref="InterPro:IPR005177" /db_xref="InterPro:IPR026565" /db_xref="SubtiList:BG11659" /db_xref="UniProtKB/Swiss-Prot:P54470" /translation="MNNRIIYVVSDSVGETAELVVKAALSQFNGSADDTHVRRIPYVE DIGTINEVISLAKADGGIICFTLVVPEIREYLIAEAEKANVLYYDIIGPLIDKMETAY GLTAKYEPGRVRQLDEDYFKKVEAIEFAVKYDDGRDPRGILKADIVLIGVSRTSKTPL SQYLAHKRLKVANVPIVPEVDPPEELFNVDPKKCIGLKISPDKLNHIRKERLKSLGLN DKAIYANINRIKEELEYFEKIVDRIGCQVVDVSNKAVEETANIIHHLKTKNI*" /label="ppsR CDS" gene complement(2273536..2274348) /gene="ppsR" /locus_tag="BSU_25240" /old_locus_tag="BSU25240" /label="ppsR gene" CDS complement(2274374..2275012) /gene="ccpN" /locus_tag="BSU_25250" /old_locus_tag="BSU25250" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15720552, 17011578, 17962296, 18511073, 18586936, 19202299, 19726675, 28178965" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15720552, 17011578, 17962296, 18511073, 18586936, 19202299, 19726675, 28178965; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of gluconeogenesis" /protein_id="NP_390403.1" /db_xref="EnsemblGenomes-Gn:BSU25250" /db_xref="EnsemblGenomes-Tr:CAB14454" /db_xref="GOA:O34994" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR016842" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:3FV6" /db_xref="PDB:3FWR" /db_xref="PDB:3FWS" /db_xref="SubtiList:BG13768" /db_xref="UniProtKB/Swiss-Prot:O34994" /translation="MSTIELNKRQEHILQIVKENGPITGEHIAEKLNLTRATLRPDLA ILTMSGFLEARPRVGYFYTGKTGTQLLADKLKKLQVKDFQSIPVVIHENVSVYDAICT MFLEDVGTLFVVDRDAVLVGVLSRKDLLRASIGQQELTSVPVHIIMTRMPNITVCRRE DYVMDIAKHLIEKQIDALPVIKDTDKGFEVIGRVTKTNMTKILVSLSENEIL*" /label="ccpN CDS" gene complement(2274374..2275012) /gene="ccpN" /locus_tag="BSU_25250" /old_locus_tag="BSU25250" /label="ccpN gene" S_feature complement(2275013..2275144) /Source="Nicolas_S_feature" /locus_tag="new_2605598_2605729_c" /HighExp="G135, dia5, G180, G150, dia15, H2O2, LBGexp, Lbexp, Oxctl, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="1, 1, 0.999, 0.998" /TUlongSig="SigGF" /TUlongPSig="0.979" /label="S955" promotor_-10 complement(2275138..2275157) /Source="Nicolas_upshift_promotors" /id="U1970" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2057 /SigmaFactorBS="atggtaagcttggcggatgagatcaagtCCTTTGCGaatatg aatgccctTATTGTAAAATAAAGAGAGAaaaggcggttgctgtgtgatcggtaatcgt c" /listShort="S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948" /listLong="cccA, S947, S946, trmK, yqfO" /label="promotor_-10" CDS complement(2275145..2277184) /gene="glyS" /locus_tag="BSU_25260" /old_locus_tag="BSU25260" /EC_number="6.1.1.14" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 15890195; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycyl-tRNA synthetase (beta subunit)" /protein_id="NP_390404.2" /db_xref="EnsemblGenomes-Gn:BSU25260" /db_xref="EnsemblGenomes-Tr:CAB14455" /db_xref="GOA:P54381" /db_xref="InterPro:IPR006194" /db_xref="InterPro:IPR009080" /db_xref="InterPro:IPR015944" /db_xref="SubtiList:BG11658" /db_xref="UniProtKB/Swiss-Prot:P54381" /translation="MSKQDLLLEIGLEEMPARFLNESMVQLGDKLTGWLKEKNITHGE VKLFNTPRRLAVFVKDVAEKQDDIKEEAKGPAKKIALDADGNWTKAAIGFSKGQGANV EDLYIKEVKGIEYVFVQKFQAGQETKSLLPELSGLITSLHFPKNMRWGNEDLRYIRPI KWIVALFGQDVIPFSITNVESGRTTQGHRFLGHEVSIESPSAYEEQLKGQHVIADPSV RKQMIQSQLETMAAENNWSIPVDEDLLDEVNHLVEYPTALYGSFESEFLSIPEEVLVT TMKEHQRYFPVKDKNGDLLPHFITVRNGNSHAIENVARGNEKVLRARLSDASFFYKED QKLNIDANVKKLENIVFHEELGSLADKVRRVTSIAEKLAVRLQADEDTLKHVKRAAEI SKFDLVTHMIYEFPELQGIMGEKYARMLGEDEAVAAAVNEHYMPRSAGGETPSTFTGA VVAMADKLDTIASFFSIGVIPTGSQDPYGLRRQASGIVAILLDRNWGISFEELLTFVQ TDKENELLDFFTQRLKYVLNAEQIRHDVIDAVLESSELEPYSALHKAQVLEQKLGAPG FKETAEALGRVISISKKGVRGDIQPDLFENEYEAKLFDAYQTAKQNLQENFSKKDYEA ALASLAALKEPIDAYFDHTMVIADNESLKANRLAQMVSLADEIKSFANMNALIVK*" /label="glyS CDS" gene complement(2275145..2277184) /gene="glyS" /locus_tag="BSU_25260" /old_locus_tag="BSU25260" /label="glyS gene" upshifts complement(2275147) /Source="Nicolas_upshifts" /id="U1970" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2057 /SigmaFactorBS="atggtaagcttggcggatgagatcaagtCCTTTGCGaatatg aatgccctTATTGTAAAATAAAGAGAGAaaaggcggttgctgtgtgatcggtaatcgt c" /listShort="S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948" /listLong="cccA, S947, S946, trmK, yqfO" /label="upshifts" promotor_-35 complement(2275172..2275179) /Source="Nicolas_upshift_promotors" /id="U1970" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2057 /SigmaFactorBS="atggtaagcttggcggatgagatcaagtCCTTTGCGaatatg aatgccctTATTGTAAAATAAAGAGAGAaaaggcggttgctgtgtgatcggtaatcgt c" /listShort="S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948" /listLong="cccA, S947, S946, trmK, yqfO" /label="promotor_-35" downshifts complement(2275191) /Source="Nicolas_upshifts" /id="D1310" /incds=0 /nref=1 /ntot=2 /MaxReadThrough="6.14024" /MaxDrop="3.62589" /score="-9.01330408" /energy="-8.2" /TU="U1972,U1973,U1975" /idTUdmin="U1975" /TUdmin="-1320" /isTUend="FALSE" /label="downshifts" downshifts complement(2275257) /Source="Nicolas_upshifts" /id="D1311" /incds=1 /nref=10 /ntot=162 /MaxReadThrough="6.17154" /MaxDrop="3.30313" /score="-9.01330408" /energy="-8.2" /TU="U1972,U1973,U1975" /idTUdmin="U1975" /TUdmin="-1386" /isTUend="FALSE" /label="downshifts" CDS complement(2277177..2278064) /gene="glyQ" /locus_tag="BSU_25270" /old_locus_tag="BSU25270" /EC_number="6.1.1.14" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 15890195; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycyl-tRNA synthetase (alpha subunit)" /protein_id="NP_390405.1" /db_xref="EnsemblGenomes-Gn:BSU25270" /db_xref="EnsemblGenomes-Tr:CAB14456" /db_xref="GOA:P54380" /db_xref="InterPro:IPR002310" /db_xref="InterPro:IPR006194" /db_xref="SubtiList:BG11657" /db_xref="UniProtKB/Swiss-Prot:P54380" /translation="MNIQDMILTLQKHWSSQGCVLMQAYDVEKGAGTMSPYTFLRSIG PEPWKVAYVEPSRRPADGRYGENPNRLYQHHQFQVIIKPSPDNIQELYLDSLRALGID PLEHDIRFVEDNWENPSLGCAGLGWEVWLDGMEITQFTYFQQVGGLECKPVSVEITYG IERLASYIQDKENVFDLEWTSGFTVKDLFMMAEYEHSVYTFETSDVDMLFQLFSTYEK EAIKQMDNGLVHPAYDYVLKCSHTFNLLDAKGAISVTERTGYIARVRNLARKVAKTYY EEREKLGFPMLKGEGSSHE*" /label="glyQ CDS" gene complement(2277177..2278064) /gene="glyQ" /locus_tag="BSU_25270" /old_locus_tag="BSU25270" /label="glyQ gene" misc_RNA complement(2278147..2278321) /gene="tboG" /locus_tag="BSU_misc_RNA_39" /product="T-box riboswitch controlling synthesis of glycine-tRNA ligase" /experiment="publication(s) with functional evidences, PMID:1317842, 9098041, 12165569, 12547201, 15890195, 26229106" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1317842, 9098041, 12165569, 12547201, 15890195, 26229106; Product type n : RNA" /label="tboG RNA" gene complement(2278147..2278321) /gene="tboG" /locus_tag="BSU_misc_RNA_39" /label="tboG gene" downshifts complement(2278181) /Source="Nicolas_upshifts" /id="D1312" /incds=0 /nref=70 /ntot=220 /MaxReadThrough="6.60948" /MaxDrop="5.42847" /score="18.9025126" /energy="-23.3" /TU="U1972,U1973,U1975" /idTUdmin="U1976" /TUdmin=178 /isTUend="FALSE" /label="downshifts" promotor_-35 2278296..2278301 /Source="Nicolas_upshift_promotors" /id="U1971" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.955044955044955" /psig="0.955044955044955" /xcortree=959 /SigmaFactorBS="ctaaggtcgctttcatgaggtaaacgcaaGTACTTctttctc tcactgcaACATATTTTATAATAAATGatcatataaaaagatggaccaaatgtcaact t" /listShort="S956" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2278317..2278335 /Source="Nicolas_upshift_promotors" /id="U1971" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.955044955044955" /psig="0.955044955044955" /xcortree=959 /SigmaFactorBS="ctaaggtcgctttcatgaggtaaacgcaaGTACTTctttctc tcactgcaACATATTTTATAATAAATGatcatataaaaagatggaccaaatgtcaact t" /listShort="S956" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2278325..2278344) /Source="Nicolas_upshift_promotors" /id="U1972" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig=1 /xcortree=3007 /SigmaFactorBS="aagcatgaaacatcttatgggtgaaaacaaaAGTTGACAttt ggtccatctttTTATATGATCATTTATTATAaaatatgttgcagtgagagaaagaagt a" /listShort="NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-10" S_feature 2278327..2279739 /Source="Nicolas_S_feature" /locus_tag="new_2608912_2610324" /HighExp="C30, S8, Gly, BT, G135, Fru, S6, C90, Lbstat, Mal" /AntisenseName="recO" /AntisenseCor="0.22892689952134901" /AntisenseRegPval="-3.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.955" /TUlongSig="NA" /TUlongPSig="NA" /label="S956" upshifts 2278327 /Source="Nicolas_upshifts" /id="U1971" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.955044955044955" /psig="0.955044955044955" /xcortree=959 /SigmaFactorBS="ctaaggtcgctttcatgaggtaaacgcaaGTACTTctttctc tcactgcaACATATTTTATAATAAATGatcatataaaaagatggaccaaatgtcaact t" /listShort="S956" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2278337) /Source="Nicolas_upshifts" /id="U1972" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig=1 /xcortree=3007 /SigmaFactorBS="aagcatgaaacatcttatgggtgaaaacaaaAGTTGACAttt ggtccatctttTTATATGATCATTTATTATAaaatatgttgcagtgagagaaagaagt a" /listShort="NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="upshifts" promotor_-35 complement(2278359..2278366) /Source="Nicolas_upshift_promotors" /id="U1972" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig=1 /xcortree=3007 /SigmaFactorBS="aagcatgaaacatcttatgggtgaaaacaaaAGTTGACAttt ggtccatctttTTATATGATCATTTATTATAaaatatgttgcagtgagagaaagaagt a" /listShort="NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-35" CDS complement(2278361..2279128) /gene="recO" /locus_tag="BSU_25280" /old_locus_tag="BSU25280" /function="16.9: Replicate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10323239, 15186413, 16061691, 26001966" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10323239, 15186413, 16061691, 26001966; Product type f: factor" /codon_start=1 /transl_table=11 /product="DNA double strand break repair and homologous recombination factor" /protein_id="NP_390406.2" /db_xref="EnsemblGenomes-Gn:BSU25280" /db_xref="EnsemblGenomes-Tr:CAB14457" /db_xref="GOA:P42095" /db_xref="InterPro:IPR003717" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR022572" /db_xref="SubtiList:BG11189" /db_xref="UniProtKB/Swiss-Prot:P42095" /translation="MLTKCEGIVLRTNDYGETNKIVTLLTREHGKIGVMARGAKKPNS RLSAVSQPFLYGSFLMQKTSGLGTLQQGEMILSMRGIREDLFLTAYAAYVAELVDRGT EEKKPNPYLFEFILESLKQLNEGTDPDVITFIVQMKMLGVMGLYPELNHCVHCKSQDG TFHFSVRDNGFICHRCFEKDPYRIPIKPQTARLLRLFYYFDLSRLGNVSLKEETKAEL KQVIDLYYEEYSGLYLKSKRFLDQMESMKHLMGENKS*" /label="recO CDS" gene complement(2278361..2279128) /gene="recO" /locus_tag="BSU_25280" /old_locus_tag="BSU25280" /label="recO gene" CDS complement(2279165..2279308) /gene="yqzL" /locus_tag="BSU_25289" /old_locus_tag="BSU25289" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097761.1" /db_xref="EnsemblGenomes-Gn:BSU25289" /db_xref="EnsemblGenomes-Tr:CAX52661" /db_xref="InterPro:IPR025617" /db_xref="UniProtKB/Swiss-Prot:C0H452" /translation="MLNFTWNVFSQTGNVDTYLLFKELEKENMERPEELEDELARFDY PIL*" /label="yqzL CDS" gene complement(2279165..2279308) /gene="yqzL" /locus_tag="BSU_25289" /old_locus_tag="BSU25289" /label="yqzL gene" S_feature complement(2279309..2279455) /Source="Nicolas_S_feature" /locus_tag="new_2609894_2610040_c" /HighExp="Lbstat, T1.30H, T2.0H, M9-stat, S2, T3.0H, S5, M0t90, T2.30H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigB" /TUshortPSig="0.999, 0.998, 1" /TUlongSig="SigGF" /TUlongPSig="0.979" /label="S957" CDS complement(2279456..2280361) /gene="era" /locus_tag="BSU_25290" /old_locus_tag="BSU25290" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12399511, 12427945, 12682299, 21646538, 22720735, 27834201, 28132488" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12399511, 12427945, 12682299, 21646538, 22720735, 27834201, 28132488; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="maturation of 16S RNA and assembly of 30S ribosomal subunit GTPase" /protein_id="NP_390407.1" /db_xref="EnsemblGenomes-Gn:BSU25290" /db_xref="EnsemblGenomes-Tr:CAB14458" /db_xref="GOA:P42182" /db_xref="InterPro:IPR004044" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR005662" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR009019" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030388" /db_xref="SubtiList:BG11188" /db_xref="UniProtKB/Swiss-Prot:P42182" /translation="MTNESFKSGFVSIIGRPNVGKSTFLNRVIGQKIAIMSDKPQTTR NKVQGVLTTGTSQTIFIDTPGIHKPKHKLGDFMMKVAQNTLKEVDLILFMINAEEGYG KGDEFIIEKLQTMSTPVFLIVNKIDKIHPDQLLLLIDEYRKRYPFKEIVPISALEGNN IETLLAQIEAYLPEGPQFYPSDQVTDHPERFIISELIREKVLHLTREEIPHSIAVAIE SIKGQDNGSVHVAATIVVERDSQKGIVIGKKGSLLKEVGKRARADIEALLGSRVYLEL WVKVQKDWRNKMSQLRDFGFKEDEY*" /label="era CDS" gene complement(2279456..2280361) /gene="era" /locus_tag="BSU_25290" /old_locus_tag="BSU25290" /label="era gene" CDS complement(2280342..2280752) /gene="cdd" /locus_tag="BSU_25300" /old_locus_tag="BSU25300" /EC_number="3.5.4.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2526291, 8157589, 10217788, 11851403, 22720735, 25890046" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2526291, 8157589, 10217788, 11851403, 22720735, 25890046; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cytidine/deoxycytidine deaminase" /protein_id="NP_390408.1" /db_xref="EnsemblGenomes-Gn:BSU25300" /db_xref="EnsemblGenomes-Tr:CAB14459" /db_xref="GOA:P19079" /db_xref="InterPro:IPR002125" /db_xref="InterPro:IPR006262" /db_xref="InterPro:IPR016192" /db_xref="InterPro:IPR016193" /db_xref="PDB:1JTK" /db_xref="PDB:1UWZ" /db_xref="PDB:1UX0" /db_xref="PDB:1UX1" /db_xref="SubtiList:BG10477" /db_xref="UniProtKB/Swiss-Prot:P19079" /translation="MNRQELITEALKARDMAYAPYSKFQVGAALLTKDGKVYRGCNIE NAAYSMCNCAERTALFKAVSEGDTEFQMLAVAADTPGPVSPCGACRQVISELCTKDVI VVLTNLQGQIKEMTVEELLPGAFSSEDLHDERKL*" /label="cdd CDS" gene complement(2280342..2280752) /gene="cdd" /locus_tag="BSU_25300" /old_locus_tag="BSU25300" /label="cdd gene" promotor_-10 complement(2280790..2280809) /Source="Nicolas_upshift_promotors" /id="U1973" /multdbtbs="SigA,SigB" /comp="M7" /sig="SigA" /pcomp="0.873126873126873" /psig="0.999000999001" /xcortree=528 /SigmaFactorBS="attcttacatttattttacatttttagaaatgggCGTGaaaa aaagcgcgcgATTATGTAAAATATAAAGTGatagcggtaccattataggtaagagagg a" /listShort="cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948" /listLong="cccA, S947, S946, trmK, yqfO" /label="promotor_-10" upshifts complement(2280801) /Source="Nicolas_upshifts" /id="U1973" /multdbtbs="SigA,SigB" /comp="M7" /sig="SigA" /pcomp="0.873126873126873" /psig="0.999000999001" /xcortree=528 /SigmaFactorBS="attcttacatttattttacatttttagaaatgggCGTGaaaa aaagcgcgcgATTATGTAAAATATAAAGTGatagcggtaccattataggtaagagagg a" /listShort="cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948" /listLong="cccA, S947, S946, trmK, yqfO" /label="upshifts" S_feature complement(2280803..2280870) /Source="Nicolas_S_feature" /locus_tag="new_2611388_2611455_c" /HighExp="Oxctl, H2O2, G180, G150, GM 120, S1, G135, Diami, LBGtran, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="0.998, 1" /TUlongSig="SigGF" /TUlongPSig="0.979" /label="S958" promotor_-35 complement(2280824..2280827) /Source="Nicolas_upshift_promotors" /id="U1973" /multdbtbs="SigA,SigB" /comp="M7" /sig="SigA" /pcomp="0.873126873126873" /psig="0.999000999001" /xcortree=528 /SigmaFactorBS="attcttacatttattttacatttttagaaatgggCGTGaaaa aaagcgcgcgATTATGTAAAATATAAAGTGatagcggtaccattataggtaagagagg a" /listShort="cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948" /listLong="cccA, S947, S946, trmK, yqfO" /label="promotor_-35" CDS complement(2280871..2281242) /gene="unpK" /locus_tag="BSU_25310" /old_locus_tag="BSU25310" /EC_number="2.7.1.66" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12923107, 17535816, 19935659, 28872301; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="undecaprenol kinase" /protein_id="NP_390409.2" /db_xref="EnsemblGenomes-Gn:BSU25310" /db_xref="EnsemblGenomes-Tr:CAB14460" /db_xref="GOA:P19638" /db_xref="InterPro:IPR000829" /db_xref="InterPro:IPR033717" /db_xref="InterPro:IPR036945" /db_xref="SubtiList:BG11040" /db_xref="UniProtKB/Swiss-Prot:P19638" /translation="MDSKDHRNELNRFFKSFVHAGRGIWETARTERNFQFHAAAACAV LICGFLVELSIIEWMIIFLLIGGMFSLELLNTAIEHTVDLITDKHHPLAKAAKDAAAG AVCVFAVISCIIGLLIFLPKL*" /label="unpK CDS" gene complement(2280871..2281242) /gene="unpK" /locus_tag="BSU_25310" /old_locus_tag="BSU25310" /label="unpK gene" CDS complement(2281223..2281696) /gene="rnrY" /locus_tag="BSU_25320" /old_locus_tag="BSU25320" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16511207, 16818608, 19181801, 20639334, 20807199, 23273979, 23638028, 24511998, 24901994, 28031281; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endonuclease involved in 70S ribosomes quality control" /protein_id="NP_390410.2" /db_xref="EnsemblGenomes-Gn:BSU25320" /db_xref="EnsemblGenomes-Tr:CAB14461" /db_xref="GOA:P46347" /db_xref="InterPro:IPR002036" /db_xref="InterPro:IPR020549" /db_xref="InterPro:IPR023091" /db_xref="SubtiList:BG11656" /db_xref="UniProtKB/Swiss-Prot:P46347" /translation="MSLLIDIVDETGSVSEEMLKEVENLLQFAAEREGVQDQAEVSVT IVSNDDIHQINKEYRGKDAPTDVISFALEEEGEGEIEIVGAEMPPVLGDIIISADRTR EQAEEYNHSFKRELGFLAVHGFLHLLGYDHMTKEEEEEMFTKQKELLDAYGLKRS*" /label="rnrY CDS" gene complement(2281223..2281696) /gene="rnrY" /locus_tag="BSU_25320" /old_locus_tag="BSU25320" /label="rnrY gene" CDS complement(2281697..2283832) /gene="pgpH" /locus_tag="BSU_25330" /old_locus_tag="BSU25330" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16751502, 26240071, 27378384" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16751502, 26240071, 27378384; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="c-di-AMP-degrading phosphodiesterases" /protein_id="NP_390411.1" /db_xref="EnsemblGenomes-Gn:BSU25330" /db_xref="EnsemblGenomes-Tr:CAB14462" /db_xref="GOA:P46344" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR006674" /db_xref="InterPro:IPR006675" /db_xref="InterPro:IPR011621" /db_xref="InterPro:IPR011624" /db_xref="SubtiList:BG11655" /db_xref="UniProtKB/Swiss-Prot:P46344" /translation="MLKKKAKTKSSSKKWSSFKNARSMHVLLYLLLAAIMFALLFVHV KPETLDLDLFSVSDKTIYAPATVEDQKATEEKKQAAEDAVEDQYTLKKEYTDNRIDLV SSIFDSISEVKKSSEEGSKSPSEKSMVKSVKDKLTSDVNDSISEDSIKTLLKADSEDF SFVRDTVITAVNTVMSSEIPSDKLSDAKDKVEKELKSNSIPSKYLGAATEIGRFAIIP NYVFDPKATEAKRQEASDNVQQVQIKQGQVLVEENDLIDREVYRKLELTGLLNNSNLF KPISGLLIMIGLFIATLVYYFEKQKQNLKFKNQSILLFSIITTLLLVIMEVVSLFQKM EYNNIGYLVPIAAGAILIKLLMNERIAILGSIILAICGSMMFNQGVTGTFNYVIGIYY LISGISGVLFLGKHNARSKILQTGLFVAFINMVVVLSLLLIQNTALSGLEIGTLMLMG VVSGFASSVLIIGLMPFFETGFGILSTMRLLELSNPNHPLLRKILTETPGTYHHSVMV ANLSEAACEAVGANGLLARVGAYYHDLGKTKRPQYFIENQMNIDNPHDKLSPQLSKNI IISHTTDGANMLRSYKFPKELVDIAEQHHGTSLLKFFYYKAKEKGDQITEEEFRYPGP KPQSKEAAIISVADSVEAAVRSMHNPNPERIEKLVRGIISDKLQDGQFSECDLTFKEL DTIAKTLCATLKGIFHSRIEYPEATKKVK*" /label="pgpH CDS" gene complement(2281697..2283832) /gene="pgpH" /locus_tag="BSU_25330" /old_locus_tag="BSU25330" /label="pgpH gene" promotor_-35 2283676..2283681 /Source="Nicolas_upshift_promotors" /id="U1974" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1188 /SigmaFactorBS="gttgccggagcgtaaatggtcttgtcgctgactgaaaacaGG TCTAaatcaagtgtttccgGCTTAACATGTACAAAGAGcaaagcaaacataatggcag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2283696 /Source="Nicolas_upshifts" /id="U1974" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1188 /SigmaFactorBS="gttgccggagcgtaaatggtcttgtcgctgactgaaaacaGG TCTAaatcaagtgtttccgGCTTAACATGTACAAAGAGcaaagcaaacataatggcag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2283697..2283715 /Source="Nicolas_upshift_promotors" /id="U1974" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1188 /SigmaFactorBS="gttgccggagcgtaaatggtcttgtcgctgactgaaaacaGG TCTAaatcaagtgtttccgGCTTAACATGTACAAAGAGcaaagcaaacataatggcag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2283911..2284870) /gene="phoH" /locus_tag="BSU_25340" /old_locus_tag="BSU25340" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12762842" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12762842; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="phosphate starvation-induced protein" /protein_id="NP_390412.2" /db_xref="EnsemblGenomes-Gn:BSU25340" /db_xref="EnsemblGenomes-Tr:CAB14476" /db_xref="GOA:P46343" /db_xref="InterPro:IPR003714" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11337" /db_xref="UniProtKB/Swiss-Prot:P46343" /translation="MTEHLLAMNQKLKNPDEALSLFGNQDSFLKLMEKDLNLNIITRG ETIYVSGDDESFQIADRLLGSLLALIRKGIEISERDVIYAIKMAKKNELEYFESMYEE EITKNAKGKSIRVKTMGQREYVAAMKRNDLVFGIGPAGTGKTYLAVVKAVHALKNGHI KKIILTRPAVEAGESLGFLPGDLKEKVDPYLRPLYDALHDVLGADHTERLMERGIIEI APLAYMRGRTLDDAYVILDEAQNTTPAQMKMFLTRLGFGSKMIITGDVSQIDLPKGVK SGLAVAKEMLKGIDGISMIELDQTDVVRHPLVAKIIEAYDKQN*" /label="phoH CDS" gene complement(2283911..2284870) /gene="phoH" /locus_tag="BSU_25340" /old_locus_tag="BSU25340" /label="phoH gene" downshifts complement(2283926) /Source="Nicolas_upshifts" /id="D1313" /incds=0 /nref=1 /ntot=63 /MaxReadThrough="6.04676" /MaxDrop="4.50442" /score="9.12152318" /energy="-13.1" /TU="U1975,U1976,U1977" /idTUdmin="U1978" /TUdmin=1034 /isTUend="FALSE" /label="downshifts" CDS complement(2284867..2286063) /gene="yqfD" /locus_tag="BSU_25350" /old_locus_tag="BSU25350" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14523133, 26735940; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage IV sporulation protein; putative UDP-glucose-4-epimerase" /protein_id="NP_390413.2" /db_xref="EnsemblGenomes-Gn:BSU25350" /db_xref="EnsemblGenomes-Tr:CAB14477" /db_xref="GOA:P54469" /db_xref="InterPro:IPR010690" /db_xref="SubtiList:BG11654" /db_xref="UniProtKB/Swiss-Prot:P54469" /translation="MKNKWLSFFSGKVQLELTGRGIERLLNECTRQGIPVFHVKKKKE AVSLYIQLQDVHAFRRVRSKFKCKARFINRKGFPFLLLKSKLNIGFTIGFAIFFILLF LLSNMVWKIDVTGAKPETEHQMRQHLNEIGVKKGRLQFLMMSPEKIQKSLTNGIDNIT WVGVDLKGTTIHMKVVEKNEPEKEKYVSPRNIVAKKKATITRMFVQKGQPMAAIHDHV EKGQLLVSGLIGSEDHQQEVASKAEIYGETWYRSEVTVPLETLFNVYTGKVRTKHKLS FGSLAIPIWGMTFKKEELKHPKTEQEKHSLHFLGFKLPVSYVKEQTRESEEALRKYTK EEAVQEGIKLGKQDVEDKIGENGEVKSEKVLHQTVENGKVKLIILYQVIEDIVQTTPI VRETEE*" /label="yqfD CDS" gene complement(2284867..2286063) /gene="yqfD" /locus_tag="BSU_25350" /old_locus_tag="BSU25350" /label="yqfD gene" promotor_-10 complement(2284934..2284953) /Source="Nicolas_upshift_promotors" /id="U1975" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.493506493506494" /psig="0.998001998001998" /xcortree=609 /SigmaFactorBS="aaacggcgaggtgaaaagtgaaaaaGTTTTGCAccagactgt tgagAATGGTAAAGTAAAGTTGATtattctctaccaagttatagaagatatcgttcaa a" /listShort="phoH, yqfF, yqfG, dgkA, S958, cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL" /listLong="S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA, S947, S946, trmK, yqfO" /label="promotor_-10" upshifts complement(2284939) /Source="Nicolas_upshifts" /id="U1975" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.493506493506494" /psig="0.998001998001998" /xcortree=609 /SigmaFactorBS="aaacggcgaggtgaaaagtgaaaaaGTTTTGCAccagactgt tgagAATGGTAAAGTAAAGTTGATtattctctaccaagttatagaagatatcgttcaa a" /listShort="phoH, yqfF, yqfG, dgkA, S958, cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL" /listLong="S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA, S947, S946, trmK, yqfO" /label="upshifts" promotor_-35 complement(2284967..2284974) /Source="Nicolas_upshift_promotors" /id="U1975" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.493506493506494" /psig="0.998001998001998" /xcortree=609 /SigmaFactorBS="aaacggcgaggtgaaaagtgaaaaaGTTTTGCAccagactgt tgagAATGGTAAAGTAAAGTTGATtattctctaccaagttatagaagatatcgttcaa a" /listShort="phoH, yqfF, yqfG, dgkA, S958, cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL" /listLong="S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA, S947, S946, trmK, yqfO" /label="promotor_-35" promotor_-10 complement(2285014..2285032) /Source="Nicolas_upshift_promotors" /id="U1976" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=741 /SigmaFactorBS="agaggctttgcgaaaatatacaaaagaagaagcAGTTCAAga aggcattaaattGGGTAAACAGGATGTAGAGgataaaataggcgaaaacggcgaggtg a" /listShort="phoH, yqfF, yqfG, dgkA, S958, cdd, era, S957, yqzL, recO" /listLong="NA, glyQ, glyS" /label="promotor_-10" upshifts complement(2285026) /Source="Nicolas_upshifts" /id="U1976" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=741 /SigmaFactorBS="agaggctttgcgaaaatatacaaaagaagaagcAGTTCAAga aggcattaaattGGGTAAACAGGATGTAGAGgataaaataggcgaaaacggcgaggtg a" /listShort="phoH, yqfF, yqfG, dgkA, S958, cdd, era, S957, yqzL, recO" /listLong="NA, glyQ, glyS" /label="upshifts" promotor_-35 complement(2285047..2285053) /Source="Nicolas_upshift_promotors" /id="U1976" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=741 /SigmaFactorBS="agaggctttgcgaaaatatacaaaagaagaagcAGTTCAAga aggcattaaattGGGTAAACAGGATGTAGAGgataaaataggcgaaaacggcgaggtg a" /listShort="phoH, yqfF, yqfG, dgkA, S958, cdd, era, S957, yqzL, recO" /listLong="NA, glyQ, glyS" /label="promotor_-35" upshifts complement(2285241) /Source="Nicolas_upshifts" /id="U1977" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=910 /SigmaFactorBS="acagtcccgcttgaAACATTAtttaacgtctatacGGGCAAA GTAAGgacaaagcacaagctttcttttggttctttggcaatcccgatctgggggatga c" /listShort="phoH, yqfF, yqfG, dgkA" /listLong="S958, cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /label="upshifts" promotor_-10 complement(2285255..2285266) /Source="Nicolas_upshift_promotors" /id="U1977" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=910 /SigmaFactorBS="acagtcccgcttgaAACATTAtttaacgtctatacGGGCAAA GTAAGgacaaagcacaagctttcttttggttctttggcaatcccgatctgggggatga c" /listShort="phoH, yqfF, yqfG, dgkA" /listLong="S958, cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /label="promotor_-10" promotor_-35 complement(2285281..2285287) /Source="Nicolas_upshift_promotors" /id="U1977" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=910 /SigmaFactorBS="acagtcccgcttgaAACATTAtttaacgtctatacGGGCAAA GTAAGgacaaagcacaagctttcttttggttctttggcaatcccgatctgggggatga c" /listShort="phoH, yqfF, yqfG, dgkA" /listLong="S958, cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /label="promotor_-35" CDS complement(2286082..2286363) /gene="yqfC" /locus_tag="BSU_25360" /old_locus_tag="BSU25360" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12662922" /codon_start=1 /transl_table=11 /product="conserved sporulation protein of unknown function" /protein_id="NP_390414.1" /db_xref="EnsemblGenomes-Gn:BSU25360" /db_xref="EnsemblGenomes-Tr:CAB14478" /db_xref="InterPro:IPR022476" /db_xref="InterPro:IPR022477" /db_xref="SubtiList:BG11653" /db_xref="UniProtKB/Swiss-Prot:P54468" /translation="MGQRKNRMKAWLTRALEIPPDVMMDLPRITMVGRLHIYIENHRG LLLFSENEVRLMLKQGQCIISGKNFVIKAILPEEILLEGTIDVVRYVES*" /label="yqfC CDS" gene complement(2286082..2286363) /gene="yqfC" /locus_tag="BSU_25360" /old_locus_tag="BSU25360" /label="yqfC gene" CDS complement(2286420..2286839) /gene="yqfB" /locus_tag="BSU_25370" /old_locus_tag="BSU25370" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390415.2" /db_xref="EnsemblGenomes-Gn:BSU25370" /db_xref="EnsemblGenomes-Tr:CAB14479" /db_xref="GOA:P54467" /db_xref="InterPro:IPR016788" /db_xref="SubtiList:BG11652" /db_xref="UniProtKB/Swiss-Prot:P54467" /translation="MEDLLTNPLIIAAIIGIISAIFGKKSKEEKQNSQKRKKPQHVQS ASPQKKQSKEDAPAPIPNRMEQARREAEERRRETARNLKGLERDLAAAKQKTVYTKQK MLQVNKDTVVQGIVLGEVFGPPRAKKPHRTMRPARKN*" /label="yqfB CDS" gene complement(2286420..2286839) /gene="yqfB" /locus_tag="BSU_25370" /old_locus_tag="BSU25370" /label="yqfB gene" downshifts complement(2286434) /Source="Nicolas_upshifts" /id="D1314" /incds=0 /nref=232 /ntot=257 /MaxReadThrough="4.55662" /MaxDrop="7.47609" /score="-3.87904232" /energy="-16.8" /TU="U1978" /idTUdmin="U1980" /TUdmin=242 /isTUend="FALSE" /label="downshifts" CDS complement(2286864..2287859) /gene="floA" /locus_tag="BSU_25380" /old_locus_tag="BSU25380" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12501411, 22753055" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12501411, 22753055; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="flotillin-like protein involved in membrane lipid rafts" /protein_id="NP_390416.1" /db_xref="EnsemblGenomes-Gn:BSU25380" /db_xref="EnsemblGenomes-Tr:CAB14480" /db_xref="GOA:P54466" /db_xref="InterPro:IPR022853" /db_xref="SubtiList:BG11651" /db_xref="UniProtKB/Swiss-Prot:P54466" /translation="MDPSTLMILAIVAVAIIVLAVFFTFVPVMLWISALAAGVKISIF TLVGMRLRRVIPNRVVNPLIKAHKAGLNVGTNQLESHYLAGGNVDRVVNALIAAQRAN IELTFERCAAIDLAGRDVLEAVQMSVNPKVIETPFIAGVAMDGIEVKAKARITVRANI ERLVGGAGEETIVARVGEGIVSTIGSSDNHKKVLENPDMISQTVLGKGLDSGTAFEIL SIDIADVDIGKNIGAILQTDQAEADKNIAQAKAEERRAMAVAQEQEMRARVEEMRAKV VEAEAEVPLAMAEALREGNIGVMDYMNIKNIDADTEMRDSFGKLTKDPSDEDRKS*" /label="floA CDS" gene complement(2286864..2287859) /gene="floA" /locus_tag="BSU_25380" /old_locus_tag="BSU25380" /label="floA gene" CDS complement(2287881..2289194) /gene="nfeDA" /locus_tag="BSU_25390" /old_locus_tag="BSU25390" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735, 22753055; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane bound peptidase of unkwnown function" /protein_id="NP_390417.1" /db_xref="EnsemblGenomes-Gn:BSU25390" /db_xref="EnsemblGenomes-Tr:CAB14481" /db_xref="GOA:P54465" /db_xref="InterPro:IPR002810" /db_xref="InterPro:IPR002825" /db_xref="InterPro:IPR029045" /db_xref="SubtiList:BG11650" /db_xref="UniProtKB/Swiss-Prot:P54465" /translation="MLQIKGFRAALLGIFLLSLLGVQLNAKAEKQTVYVIPVEKNVEQ GLASFLSRSLQDAKDAHADHIILDINTPGGLVKSAIDMADLITESEIPVTAYVNKRAL SAGAYIALQADHIYMAPGGKMGAAAIVDGQGNAADQKAQSLWLAEMEDAAVKNNRDPK YALAMADPDIDAKEVGAPKGDLLTLNADKAIEVGYSEGTADNLSTLVKKLGFEKAQIS YAKESFAEKTARWLTNPVIVPILLTIAFLGLTVELFSPGVGLPGTAGLIALLLFFYGH LAAGLAGYETVLLFIAGVILILLEIFLPGGIIGLLGLGAIIASLFLAAGSFTVMAVSL LIASAVSITAFILLTRVLGKRMKFFKKLILNDSTNTESGYVSNQTRTDLMGKVGITFT PLRPSGTVIIDDERLDVVSEGSFTEKDKKVKVIKVEGSRIVVREI*" /label="nfeDA CDS" gene complement(2287881..2289194) /gene="nfeDA" /locus_tag="BSU_25390" /old_locus_tag="BSU25390" /label="nfeDA gene" promotor_-10 complement(2289230..2289245) /Source="Nicolas_upshift_promotors" /id="U1978" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1696 /SigmaFactorBS="atctttctaagagagatgtctttttttatacataaaaaaaTG AAACCTTTgatacatttgttACGTATGAAGAGAAGGcacttattataaaaggaaggag g" /listShort="yqeZ, yqfA, yqfB, yqfC, yqfD" /listLong="phoH, yqfF, yqfG" /label="promotor_-10" upshifts complement(2289247) /Source="Nicolas_upshifts" /id="U1978" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1696 /SigmaFactorBS="atctttctaagagagatgtctttttttatacataaaaaaaTG AAACCTTTgatacatttgttACGTATGAAGAGAAGGcacttattataaaaggaaggag g" /listShort="yqeZ, yqfA, yqfB, yqfC, yqfD" /listLong="phoH, yqfF, yqfG" /label="upshifts" promotor_-35 complement(2289258..2289267) /Source="Nicolas_upshift_promotors" /id="U1978" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1696 /SigmaFactorBS="atctttctaagagagatgtctttttttatacataaaaaaaTG AAACCTTTgatacatttgttACGTATGAAGAGAAGGcacttattataaaaggaaggag g" /listShort="yqeZ, yqfA, yqfB, yqfC, yqfD" /listLong="phoH, yqfF, yqfG" /label="promotor_-35" CDS complement(2289325..2289771) /gene="yqeY" /locus_tag="BSU_25400" /old_locus_tag="BSU25400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 17284460, 22720735, 25149203" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function with tRNA aminoacid amidase domain" /protein_id="NP_390418.1" /db_xref="EnsemblGenomes-Gn:BSU25400" /db_xref="EnsemblGenomes-Tr:CAB14482" /db_xref="GOA:P54464" /db_xref="InterPro:IPR003789" /db_xref="InterPro:IPR019004" /db_xref="InterPro:IPR023168" /db_xref="PDB:1NG6" /db_xref="SubtiList:BG11649" /db_xref="UniProtKB/Swiss-Prot:P54464" /translation="MSLLERLNQDMKLYMKNREKDKLTVVRMVKASLQNEAIKLKKDS LTEDEELTVLSRELKQRKDSLQEFSNANRLDLVDKVQKELDILEVYLPEQLSEEELRT IVNETIAEVGASSKADMGKVMGAIMPKVKGKADGSLINKLVSSQLS*" /label="yqeY CDS" gene complement(2289325..2289771) /gene="yqeY" /locus_tag="BSU_25400" /old_locus_tag="BSU25400" /label="yqeY gene" downshifts complement(2289338) /Source="Nicolas_upshifts" /id="D1315" /incds=0 /nref=248 /ntot=267 /MaxReadThrough="5.1355" /MaxDrop="8.31948" /score="17.2548348" /energy="-10.3" /TU="U1980" /idTUdmin="U1983" /TUdmin=1760 /isTUend="FALSE" /label="downshifts" downshifts complement(2289536) /Source="Nicolas_upshifts" /id="D1316" /incds=1 /nref=1 /ntot=34 /MaxReadThrough="8.99916" /MaxDrop="1.9798" /score="17.2548348" /energy="-10.3" /TU="U1980" /idTUdmin="U1983" /TUdmin=1562 /isTUend="FALSE" /label="downshifts" CDS complement(2289786..2289959) /gene="rpsU" /locus_tag="BSU_25410" /old_locus_tag="BSU25410" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 22720735, 23002217, 25035996" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 22720735, 23002217, 25035996; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S21" /protein_id="NP_390419.1" /db_xref="EnsemblGenomes-Gn:BSU25410" /db_xref="EnsemblGenomes-Tr:CAB14483" /db_xref="GOA:P21478" /db_xref="InterPro:IPR001911" /db_xref="InterPro:IPR018278" /db_xref="SubtiList:BG11648" /db_xref="UniProtKB/Swiss-Prot:P21478" /translation="MSKTVVRKNESLEDALRRFKRSVSKTGTLQEARKREFYEKPSVK RKKKSEAARKRKF*" /label="rpsU CDS" gene complement(2289786..2289959) /gene="rpsU" /locus_tag="BSU_25410" /old_locus_tag="BSU25410" /label="rpsU gene" misc_feature 2289895..2289899 /Source="Nicolas_upshift_promotors" /id="U1979" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.877122877122877" /psig="0.113886113886114" /xcortree=55 /SigmaFactorBS="tttttcataaaattcacgctttcttgcttcttgcaaagtacc tgtctttgatacaCTGCGtttgaagcgacgaagagcatcttcaagcgattcgtttttt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2289900 /Source="Nicolas_upshifts" /id="U1979" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.877122877122877" /psig="0.113886113886114" /xcortree=55 /SigmaFactorBS="tttttcataaaattcacgctttcttgcttcttgcaaagtacc tgtctttgatacaCTGCGtttgaagcgacgaagagcatcttcaagcgattcgtttttt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2290020..2290039) /Source="Nicolas_upshift_promotors" /id="U1980" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.547452547452547" /psig="0.998001998001998" /xcortree=2702 /SigmaFactorBS="ggcagtcgcactcatgacggaaaagtgaactcactTAGTTGA CctgactgatggctTATATTATAATGTCAAAGTAcatgtttatatgtgtaacttaaag g" /listShort="rpsU, yqeY, yqeZ, yqfA, yqfB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2290035) /Source="Nicolas_upshifts" /id="U1980" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.547452547452547" /psig="0.998001998001998" /xcortree=2702 /SigmaFactorBS="ggcagtcgcactcatgacggaaaagtgaactcactTAGTTGA CctgactgatggctTATATTATAATGTCAAAGTAcatgtttatatgtgtaacttaaag g" /listShort="rpsU, yqeY, yqeZ, yqfA, yqfB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2290053..2290060) /Source="Nicolas_upshift_promotors" /id="U1980" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.547452547452547" /psig="0.998001998001998" /xcortree=2702 /SigmaFactorBS="ggcagtcgcactcatgacggaaaagtgaactcactTAGTTGA CctgactgatggctTATATTATAATGTCAAAGTAcatgtttatatgtgtaacttaaag g" /listShort="rpsU, yqeY, yqeZ, yqfA, yqfB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2290078..2290083 /Source="Nicolas_upshift_promotors" /id="U1981" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=971 /SigmaFactorBS="taagccatcagtcaggtcaactaagtgagttcacttttccGT CATGagtgcgactgcctgtCTATATAATGAAAGAAAGGggttggtgaataggatgtta a" /listShort="yqeW" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2290098 /Source="Nicolas_upshifts" /id="U1981" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=971 /SigmaFactorBS="taagccatcagtcaggtcaactaagtgagttcacttttccGT CATGagtgcgactgcctgtCTATATAATGAAAGAAAGGggttggtgaataggatgtta a" /listShort="yqeW" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2290099..2290117 /Source="Nicolas_upshift_promotors" /id="U1981" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=971 /SigmaFactorBS="taagccatcagtcaggtcaactaagtgagttcacttttccGT CATGagtgcgactgcctgtCTATATAATGAAAGAAAGGggttggtgaataggatgtta a" /listShort="yqeW" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2290132..2291055 /gene="yqeW" /locus_tag="BSU_25420" /old_locus_tag="BSU25420" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na+/anion cotransporter" /protein_id="NP_390420.2" /db_xref="EnsemblGenomes-Gn:BSU25420" /db_xref="EnsemblGenomes-Tr:CAB14484" /db_xref="GOA:P54463" /db_xref="InterPro:IPR003841" /db_xref="InterPro:IPR004633" /db_xref="SubtiList:BG11647" /db_xref="UniProtKB/Swiss-Prot:P54463" /translation="MLILISFTALILFFLAGMNMLRKGLISMAYSKIEERLLLFTDHP LKAFLISIVFTGILQSSSAFMVIVIGFVSAGVLSFKRTIPMILGTNVGSTFTTEFIAI KMDIVIWVLLIGGLLFFLTGRYPLKQLGTSFLGLGIIFFCISGFSHLAGPLTKLKTGA DVLYHVNDSNWSALLIGMVLTAIIHSSSVCIGILMSFMNEGIIGLTQAMSVVLGSNIG TCITAVMAAVSGGYAAKQTAYAHVVFNVLGVALVLPFLTAATGFVEQLSPDPAQKIAH FSLLFNVVTALLFLPLTNLFYRLIHLLIPAK*" /label="yqeW CDS" gene 2290132..2291055 /gene="yqeW" /locus_tag="BSU_25420" /old_locus_tag="BSU25420" /label="yqeW gene" CDS complement(2291092..2292447) /gene="mtaB" /locus_tag="BSU_25430" /old_locus_tag="BSU25430" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6163767, 9023197, 10572129, 15339930, 18252828, 8844851, 20472640, 20584901, 27913733" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6163767, 9023197, 10572129, 15339930, 18252828, 8844851, 20472640, 20584901, 27913733; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA N(6)-threonylcarbamoyladenosine (t(6)A) methylthiotransferase" /protein_id="NP_390421.1" /db_xref="EnsemblGenomes-Gn:BSU25430" /db_xref="EnsemblGenomes-Tr:CAB14485" /db_xref="GOA:P54462" /db_xref="InterPro:IPR002792" /db_xref="InterPro:IPR005839" /db_xref="InterPro:IPR006467" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013848" /db_xref="InterPro:IPR020612" /db_xref="InterPro:IPR023404" /db_xref="InterPro:IPR034557" /db_xref="SubtiList:BG11646" /db_xref="UniProtKB/Swiss-Prot:P54462" /translation="MATVAFHTLGCKVNHYETEAIWQLFKEAGYERRDFEQTADVYVI NTCTVTNTGDKKSRQVIRRAIRQNPDGVICVTGCYAQTSPAEIMAIPGVDIVVGTQDR EKMLGYIDQYREERQPINGVSNIMKARVYEELDVPAFTDRTRASLKIQEGCNNFCTFC IIPWARGLLRSRDPEEVIKQAQQLVDAGYKEIVLTGIHTGGYGEDMKDYNFAKLLSEL DTRVEGVKRIRISSIEASQITDEVIEVLDRSDKIVNHLHIPIQSGSNTVLKRMRRKYT MEFFADRLNKLKKALPGLAVTSDVIVGFPGETEEEFMETYNFIKEHKFSELHVFPYSK RTGTPAARMEDQVDENVKNERVHRLIALSDQLAKEYASQYENEVLEIIPEEAFKETEE ENMFVGYTDNYMKVVFKGTEDMIGKIVKVKILKAGYPYNEGQFVRVVEDEITEHMRLS S*" /label="mtaB CDS" gene complement(2291092..2292447) /gene="mtaB" /locus_tag="BSU_25430" /old_locus_tag="BSU25430" /label="mtaB gene" downshifts complement(2291098) /Source="Nicolas_upshifts" /id="D1317" /incds=0 /nref=208 /ntot=260 /MaxReadThrough="1.95578" /MaxDrop="6.05381" /score="30.7201786" /energy="-11.3" /TU="NA" /idTUdmin="U1983" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2292447..2293217) /gene="rsmE" /locus_tag="BSU_25440" /old_locus_tag="BSU25440" /EC_number="2.1.1.193" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9023197, 10383760, 14517985, 16014871, 16431987, 22925577, 24598751; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylase of U1498 in 16S rRNA" /protein_id="NP_390422.1" /db_xref="EnsemblGenomes-Gn:BSU25440" /db_xref="EnsemblGenomes-Tr:CAB14486" /db_xref="GOA:P54461" /db_xref="InterPro:IPR006700" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR029026" /db_xref="InterPro:IPR029028" /db_xref="PDB:1VHK" /db_xref="SubtiList:BG11645" /db_xref="UniProtKB/Swiss-Prot:P54461" /translation="MQRYFIELTKQQIEEAPTFSITGEEVHHIVNVMRMNEGDQIICC SQDGFEAKCELQSVSKDKVSCLVIEWTNENRELPIKVYIASGLPKGDKLEWIIQKGTE LGAHAFIPFQAARSVVKLDDKKAKKKRERWTKIAKEAAEQSYRNEVPRVMDVHSFQQL LQRMQDFDKCVVAYEESSKQGEISAFSAIVSSLPKGSSLLIVFGPEGGLTEAEVERLT EQDGVTCGLGPRILRTETAPLYALSAISYQTELLRGDQ*" /label="rsmE CDS" gene complement(2292447..2293217) /gene="rsmE" /locus_tag="BSU_25440" /old_locus_tag="BSU25440" /label="rsmE gene" CDS complement(2293240..2294175) /gene="prmA" /locus_tag="BSU_25450" /old_locus_tag="BSU25450" /EC_number="2.1.1.-" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17215866, 18611379; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosomal protein L11 methyltransferase" /protein_id="NP_390423.2" /db_xref="EnsemblGenomes-Gn:BSU25450" /db_xref="EnsemblGenomes-Tr:CAB14487" /db_xref="GOA:P54460" /db_xref="InterPro:IPR004498" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11644" /db_xref="UniProtKB/Swiss-Prot:P54460" /translation="MKWSELSIHTTHEAVEPISNILHEAGASGVVIEDPLDLIKEREN VYGEIYQLDPNDYPDEGVIVKAYLPVNSFLGETVDGIKETINNLLLYNIDLGRNHITI SEVNEEEWATAWKKYYHPVKISEKFTIVPTWEEYTPVHTDELIIEMDPGMAFGTGTHP TTVLCIQALERFVQKGDKVIDVGTGSGILSIAAAMLEAESVHAYDLDPVAVESARLNL KLNKVSDIAQVKQNNLLDGIEGEHDVIVANILAEVILRFTSQAYSLLKEGGHFITSGI IGHKKQEVKEALEQAGFTIVEILSMEDWVSIIAKK*" /label="prmA CDS" gene complement(2293240..2294175) /gene="prmA" /locus_tag="BSU_25450" /old_locus_tag="BSU25450" /label="prmA gene" CDS complement(2294200..2295327) /gene="dnaJ" /locus_tag="BSU_25460" /old_locus_tag="BSU25460" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10383760, 10658654, 16385044, 16952052" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10383760, 10658654, 16385044, 16952052; Product type f: factor" /codon_start=1 /transl_table=11 /product="co-factor of molecular chaperone" /protein_id="NP_390424.2" /db_xref="EnsemblGenomes-Gn:BSU25460" /db_xref="EnsemblGenomes-Tr:CAB14488" /db_xref="GOA:P17631" /db_xref="InterPro:IPR001305" /db_xref="InterPro:IPR001623" /db_xref="InterPro:IPR002939" /db_xref="InterPro:IPR008971" /db_xref="InterPro:IPR012724" /db_xref="InterPro:IPR018253" /db_xref="InterPro:IPR036410" /db_xref="InterPro:IPR036869" /db_xref="SubtiList:BG10665" /db_xref="UniProtKB/Swiss-Prot:P17631" /translation="MSKRDYYEVLGVSKSASKDEIKKAYRKLSKKYHPDINKEAGSDE KFKEVKEAYETLSDDQKRAHYDQFGHTDPNQGFGGGGFGGGDFGGFGFDDIFSSIFGG GTRRRDPNAPRQGADLQYTMTLSFEDAAFGKETTIEIPREETCETCKGSGAKPGTNPE TCSHCGGSGQLNVEQNTPFGKVVNRRVCHHCEGTGKIIKNKCADCGGKGKIKKRKKIN VTIPAGVDDGQQLRLSGQGEPGINGGPAGDLFVVFHVRAHEFFERDGDDIYCEMPLTF AQAALGDEVEVPTLHGKVKLKIPAGTQTGTKFRLRGKGVQNVRGYGQGDQHIVVRVVT PTNLTDKQKDIIREFAEVSGNLPDEQEMSFFDKVKRAFKGD*" /label="dnaJ CDS" gene complement(2294200..2295327) /gene="dnaJ" /locus_tag="BSU_25460" /old_locus_tag="BSU25460" /label="dnaJ gene" misc_feature 2295244..2295247 /Source="Nicolas_upshift_promotors" /id="U1982" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.966033966033966" /psig="0.014985014985015" /xcortree=39 /SigmaFactorBS="tttcatctgatccggcttctttgttaatatcaggatgatatt tttttgaCAGCttccgataagcttttttaatttcatcctttgaagcgctcttacttac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2295255 /Source="Nicolas_upshifts" /id="U1982" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.966033966033966" /psig="0.014985014985015" /xcortree=39 /SigmaFactorBS="tttcatctgatccggcttctttgttaatatcaggatgatatt tttttgaCAGCttccgataagcttttttaatttcatcctttgaagcgctcttacttac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2295328..2295505) /Source="Nicolas_S_feature" /locus_tag="new_2625913_2626090_c" /HighExp="Heat, dia15, H2O2, Diami, G135, G150, G180, LPhT, Etha, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.357489" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="SigGF" /TUlongPSig="0.978" /label="S959" misc_RNA 2295367..2295457 /gene="surC" /locus_tag="BSU_misc_RNA_79" /product="sporulation-related small untranslated RNA" /experiment="publication(s) with functional evidences, PMID:16385044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16385044; Product type n: RNA" /label="surC RNA" gene 2295367..2295457 /gene="surC" /locus_tag="BSU_misc_RNA_79" /label="surC gene" CDS complement(2295527..2297362) /gene="dnaK" /locus_tag="BSU_25470" /old_locus_tag="BSU25470" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10074100, 12224648, 12799007, 17407764, 22938038, 25355936, 27148221" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10074100, 12224648, 12799007, 17407764, 22938038, 25355936, 27148221; Product type f: factor" /codon_start=1 /transl_table=11 /product="molecular chaperone, ATP-dependent" /protein_id="NP_390425.1" /db_xref="EnsemblGenomes-Gn:BSU25470" /db_xref="EnsemblGenomes-Tr:CAB14489" /db_xref="GOA:P17820" /db_xref="InterPro:IPR012725" /db_xref="InterPro:IPR013126" /db_xref="InterPro:IPR018181" /db_xref="InterPro:IPR029047" /db_xref="InterPro:IPR029048" /db_xref="PDB:2FZO" /db_xref="SubtiList:BG10664" /db_xref="UniProtKB/Swiss-Prot:P17820" /translation="MSKVIGIDLGTTNSCVAVLEGGEPKVIANAEGNRTTPSVVAFKN GERQVGEVAKRQSITNPNTIMSIKRHMGTDYKVEIEGKDYTPQEVSAIILQHLKSYAE SYLGETVSKAVITVPAYFNDAERQATKDAGKIAGLEVERIINEPTAAALAYGLDKTDE DQTILVYDLGGGTFDVSILELGDGVFEVRSTAGDNRLGGDDFDQVIIDHLVSEFKKEN GIDLSKDKMALQRLKDAAEKAKKDLSGVSSTQISLPFITAGEAGPLHLELTLTRAKFE ELSSHLVERTMGPVRQALQDAGLSASEIDKVILVGGSTRIPAVQEAIKKETGKEAHKG VNPDEVVALGAAIQGGVITGDVKDVVLLDVTPLSLGIETMGGVFTKLIDRNTTIPTSK SQVFSTAADNQTAVDIHVLQGERPMSADNKTLGRFQLTDIPPAPRGVPQIEVSFDIDK NGIVNVRAKDLGTGKEQNITIKSSSGLSDEEIERMVKEAEENADADAKKKEEIEVRNE ADQLVFQTEKTLKDLEGKVDEEQVKKANDAKDALKAAIEKNEFEEIKAKKDELQTIVQ ELSMKLYEEAAKAQQAQGGANAEGKADDNVVDAEYEEVNDDQNKK*" /label="dnaK CDS" gene complement(2295527..2297362) /gene="dnaK" /locus_tag="BSU_25470" /old_locus_tag="BSU25470" /label="dnaK gene" downshifts complement(2295550) /Source="Nicolas_upshifts" /id="D1318" /incds=0 /nref=130 /ntot=247 /MaxReadThrough="8.0737" /MaxDrop="4.023" /score="21.9400858" /energy="-13.4" /TU="U1983,U1985" /idTUdmin="U1984" /TUdmin=3565 /isTUend="FALSE" /label="downshifts" CDS complement(2297386..2297949) /gene="grpE" /locus_tag="BSU_25480" /old_locus_tag="BSU25480" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9303302, 10383760, 12682299, 17289679, 21546913, 22720735, 22938038, 26913285" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9303302, 10383760, 12682299, 17289679, 21546913, 22720735, 22938038, 26913285; Product type r: regulator" /codon_start=1 /transl_table=11 /product="nucleotide exchange factor for DnaK activity" /protein_id="NP_390426.1" /db_xref="EnsemblGenomes-Gn:BSU25480" /db_xref="EnsemblGenomes-Tr:CAB14490" /db_xref="GOA:P15874" /db_xref="InterPro:IPR000740" /db_xref="InterPro:IPR009012" /db_xref="InterPro:IPR013805" /db_xref="PDB:2G61" /db_xref="SubtiList:BG10663" /db_xref="UniProtKB/Swiss-Prot:P15874" /translation="MSEEKQTVEQNETEEQEIIEEQAAADEQQEETNESELLQNQINE LQGLLEEKENKLLRVQADFENYKRRSRLEMEASQKYRSQNIVTDLLPALDSFERALQV EADNEQTKSLLQGMEMVHRQLVEALKKEGVEAIEAVGQEFDPNLHQAVMQAEDENYGS NIVVEEMQKGYKLKDRVIRPSMVKVNQ*" /label="grpE CDS" gene complement(2297386..2297949) /gene="grpE" /locus_tag="BSU_25480" /old_locus_tag="BSU25480" /label="grpE gene" S_feature complement(2297950..2298020) /Source="Nicolas_S_feature" /locus_tag="new_2628535_2628605_c" /HighExp="LPhT, dia15, Heat, Etha, Diami, dia5, H2O2, T-0.40H, T0.30H, T0.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="SigGF" /TUlongPSig="0.978" /label="S960" CDS complement(2298021..2299052) /gene="hrcA" /locus_tag="BSU_25490" /old_locus_tag="BSU25490" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10555317, 12082092, 15109714, 16872404, 16585746, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10555317, 12082092, 15109714, 16872404, 16585746, 22720735; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of heat-shock genes" /protein_id="NP_390427.1" /db_xref="EnsemblGenomes-Gn:BSU25490" /db_xref="EnsemblGenomes-Tr:CAB14491" /db_xref="GOA:P25499" /db_xref="InterPro:IPR002571" /db_xref="InterPro:IPR021153" /db_xref="InterPro:IPR029016" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10662" /db_xref="UniProtKB/Swiss-Prot:P25499" /translation="MLTNRQLLILQVIINDFIKSAQPVGSRTLSKKDEITFSSATIRN EMADLEELGFIEKTHSSSGRVPSEKGYRYYVDHLLSPVKLTKSDLDQIHSIFKEKIFE LEKTVQKSAQILSDLTNYTSIVLGPKLSENYLKQIQIIPIQPDMAVAILVTNTGHVEN KTINFPTKMDLSDIEKLVNILNDRLSGVPMDELNERIFKEVVMYLRQHIKNYDNILDA LRSTFHSTNHVEKLFFGGKINMLNQPEFHDITRVRSLLSLIEKEQDVLKLVQSPHTGI SIKIGKENDYEEMENCSLITASYSVDQKQIGSIAIIGPTRMNYSRVVSLLQHVTSDLS KALTSLYDE*" /label="hrcA CDS" gene complement(2298021..2299052) /gene="hrcA" /locus_tag="BSU_25490" /old_locus_tag="BSU25490" /label="hrcA gene" promotor_-10 complement(2299093..2299112) /Source="Nicolas_upshift_promotors" /id="U1983" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.629370629370629" /psig=1 /xcortree=2023 /SigmaFactorBS="tgaagtttttggcgcttttttgggtgagttatAATTGACAtt tttcttgtggttTGATACTTTTGTTATAGAATtagcactcgcttattgagagtgctaa c" /listShort="hrcA, S960, grpE, dnaK, S959, dnaJ, prmA, rsmE, rimO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2299106) /Source="Nicolas_upshifts" /id="U1983" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.629370629370629" /psig=1 /xcortree=2023 /SigmaFactorBS="tgaagtttttggcgcttttttgggtgagttatAATTGACAtt tttcttgtggttTGATACTTTTGTTATAGAATtagcactcgcttattgagagtgctaa c" /listShort="hrcA, S960, grpE, dnaK, S959, dnaJ, prmA, rsmE, rimO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2299127..2299134) /Source="Nicolas_upshift_promotors" /id="U1983" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.629370629370629" /psig=1 /xcortree=2023 /SigmaFactorBS="tgaagtttttggcgcttttttgggtgagttatAATTGACAtt tttcttgtggttTGATACTTTTGTTATAGAATtagcactcgcttattgagagtgctaa c" /listShort="hrcA, S960, grpE, dnaK, S959, dnaJ, prmA, rsmE, rimO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2299133..2300272) /gene="hemN" /locus_tag="BSU_25500" /old_locus_tag="BSU25500" /EC_number="1.3.98.3" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8757728, 9371469, 10498703, 12196143, 19944166" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8757728, 9371469, 10498703, 12196143, 19944166; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="coproporphyrinogen III oxidase" /protein_id="NP_390428.2" /db_xref="EnsemblGenomes-Gn:BSU25500" /db_xref="EnsemblGenomes-Tr:CAB14492" /db_xref="GOA:P54304" /db_xref="InterPro:IPR004559" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR010723" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR034505" /db_xref="SubtiList:BG11395" /db_xref="UniProtKB/Swiss-Prot:P54304" /translation="MKSAYIHIPFCEHICHYCDFNKYFIQSQPVDEYLNALEQEMINT IAKTGQPDLKTIFIGGGTPTSLSEEQLKKLMDMINRVLKPSSDLSEFAVEANPDDLSA EKLKILKEAGVNRLSFGVQTFEDDLLEKIGRVHKQKDVFTSFERAREIGFENISLDLM FGLPGQTLKHLEHSINTALSLDAEHYSVYSLIVEPKTVFYNLMQKGRLHLPPQEQEAE MYEIVMSKMEAHGIHQYEISNFAKAGMESKHNLTYWSNEQYFGFGAGAHGYIGGTRTV NVGPVKHYIDLIAEKGFPYRDTHEVTTEEQIEEEMFLGLRKTAGVSKKRFAEKYGRSL DGLFPSVLKDLAEKGLIHNSESAVYLTHQGKLLGNEVFGAFLGEL*" /label="hemN CDS" gene complement(2299133..2300272) /gene="hemN" /locus_tag="BSU_25500" /old_locus_tag="BSU25500" /label="hemN gene" promotor_-10 complement(2300145..2300156) /Source="Nicolas_upshift_promotors" /id="U1984" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=802 /SigmaFactorBS="aaatattttattcaaagtcagccagtcgacgagTATTTAAac gcactcgaacaGGAAATGATAAAtacaatagcaaaaaccgggcagcctgatctcaaaa c" /GFF_Attribute="listShort" /listLong="hrcA, S960, grpE, dnaK, S959, dnaJ" /label="promotor_-10" upshifts complement(2300149) /Source="Nicolas_upshifts" /id="U1984" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=802 /SigmaFactorBS="aaatattttattcaaagtcagccagtcgacgagTATTTAAac gcactcgaacaGGAAATGATAAAtacaatagcaaaaaccgggcagcctgatctcaaaa c" /GFF_Attribute="listShort" /listLong="hrcA, S960, grpE, dnaK, S959, dnaJ" /label="upshifts" promotor_-35 complement(2300170..2300176) /Source="Nicolas_upshift_promotors" /id="U1984" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=802 /SigmaFactorBS="aaatattttattcaaagtcagccagtcgacgagTATTTAAac gcactcgaacaGGAAATGATAAAtacaatagcaaaaaccgggcagcctgatctcaaaa c" /GFF_Attribute="listShort" /listLong="hrcA, S960, grpE, dnaK, S959, dnaJ" /label="promotor_-35" CDS complement(2300325..2302163) /gene="lepA" /locus_tag="BSU_25510" /old_locus_tag="BSU25510" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12511492, 17110332, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosomal elongation factor, GTPase" /protein_id="NP_390429.1" /db_xref="EnsemblGenomes-Gn:BSU25510" /db_xref="EnsemblGenomes-Tr:CAB14493" /db_xref="GOA:P37949" /db_xref="InterPro:IPR000640" /db_xref="InterPro:IPR000795" /db_xref="InterPro:IPR004161" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR006297" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR013842" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031157" /db_xref="InterPro:IPR035647" /db_xref="InterPro:IPR035654" /db_xref="SubtiList:BG10441" /db_xref="UniProtKB/Swiss-Prot:P37949" /translation="MTDKEKRLERQSRIRNFSIIAHIDHGKSTLADRILEKTSAITQR EMKEQLLDSMDLERERGITIKLNSVQLKYKAKDGEEYIFHLIDTPGHVDFTYEVSRSL AACEGAILVVDAAQGIEAQTLANVYLALDNDLEILPVINKIDLPSAEPERVRQEVEDV IGLDASEAVLASAKAGIGIEEILEQIVEKVPAPTGDPEAPLKALIFDSLYDAYRGVVA YIRVVEGTVKPGQKIKMMATGKEFEVTEVGVFTPKATPTNELTVGDVGFLTASIKNVG DTRVGDTITSAANPAEEALPGYRKLNPMVYCGLYPIDTAKYNDLREALEKLELNDSSL QYEAETSQALGFGFRCGFLGMLHMEIIQERIEREFNIDLITTAPSVIYDVYMTDGEKV VVDNPSNMPDPQKIERVEEPYVKATMMVPNDYVGAVMELCQGKRGNFIDMQYLDANRV SIIYDMPLAEIVYEFFDQLKSSTKGYASFDYELIGYKPSKLVKMDIMLNGEKIDALSF IVHRDYAYERGKVIVEKLKELIPRQQFEVPVQAAIGQKIVARSTIKAMRKNVLAKCYG GDISRKRKLLEKQKEGKRRMKQVGSVEVPQEAFMAVLKMDDSPKKQ*" /label="lepA CDS" gene complement(2300325..2302163) /gene="lepA" /locus_tag="BSU_25510" /old_locus_tag="BSU25510" /label="lepA gene" downshifts complement(2300347) /Source="Nicolas_upshifts" /id="D1319" /incds=0 /nref=15 /ntot=213 /MaxReadThrough="5.2925" /MaxDrop="3.979" /score="5.45344919" /energy="-14" /TU="U1985" /idTUdmin="U1984" /TUdmin="-1232" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2302198..2302217) /Source="Nicolas_upshift_promotors" /id="U1985" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.701298701298701" /psig=1 /xcortree=2588 /SigmaFactorBS="cccagatatgatagggaacttttctctttcttgttttaCATT GaatctttacaatcctATTGATATAATCTAAGCTAGtgtattttgcgtttaatagtag g" /listShort="lepA, hemN, hrcA, S960, grpE, dnaK, S959, dnaJ, prmA, rsmE, rimO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2302215) /Source="Nicolas_upshifts" /id="U1985" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.701298701298701" /psig=1 /xcortree=2588 /SigmaFactorBS="cccagatatgatagggaacttttctctttcttgttttaCATT GaatctttacaatcctATTGATATAATCTAAGCTAGtgtattttgcgtttaatagtag g" /listShort="lepA, hemN, hrcA, S960, grpE, dnaK, S959, dnaJ, prmA, rsmE, rimO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2302233..2302237) /Source="Nicolas_upshift_promotors" /id="U1985" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.701298701298701" /psig=1 /xcortree=2588 /SigmaFactorBS="cccagatatgatagggaacttttctctttcttgttttaCATT GaatctttacaatcctATTGATATAATCTAAGCTAGtgtattttgcgtttaatagtag g" /listShort="lepA, hemN, hrcA, S960, grpE, dnaK, S959, dnaJ, prmA, rsmE, rimO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2302297..2302635) /gene="yqxA" /locus_tag="BSU_25520" /old_locus_tag="BSU25520" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390430.1" /db_xref="EnsemblGenomes-Gn:BSU25520" /db_xref="EnsemblGenomes-Tr:CAB14494" /db_xref="InterPro:IPR020534" /db_xref="SubtiList:BG10440" /db_xref="UniProtKB/Swiss-Prot:P38425" /translation="MIAYFGKCLLLVTIMFLGVLFGMQQANHGMLSMKGYHDPSLKGA FTLTDGKDNEKEASILGETVTAKDLVEKQKELEKVETFNMFSKAGKALSDTVTNTAQS MYEWIRDMNQ*" /label="yqxA CDS" gene complement(2302297..2302635) /gene="yqxA" /locus_tag="BSU_25520" /old_locus_tag="BSU25520" /label="yqxA gene" downshifts complement(2302303) /Source="Nicolas_upshifts" /id="D1320" /incds=0 /nref=11 /ntot=43 /MaxReadThrough="2.553" /MaxDrop="3.8126" /score="5.45344919" /energy="-14" /TU="NA" /idTUdmin="U1986" /TUdmin=2 /isTUend="TRUE" /label="downshifts" CDS complement(2302652..2303857) /gene="spoIIP" /locus_tag="BSU_25530" /old_locus_tag="BSU25530" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:17376078, 23834622" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17376078, 23834622; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore autolysin (stage II sporulation)" /protein_id="NP_390431.1" /db_xref="EnsemblGenomes-Gn:BSU25530" /db_xref="EnsemblGenomes-Tr:CAB14495" /db_xref="GOA:P37968" /db_xref="InterPro:IPR010897" /db_xref="SubtiList:BG10439" /db_xref="UniProtKB/Swiss-Prot:P37968" /translation="MRNKRRNRQIVVAVNGGKAVKAIFLFIVSLIVIFVLSGVLTSLR PELRPSSDSFYGIAEELPGDVFAHLLQMENHYFASDLSQTDSSFHLSRLSLKLATSIN LEDPRSFLGRELPGFAQFDTEILLAGQGTDYTNMPAESPPPSKVMEEEREANLAEIEK QQTQSDNAQKDPPKQTTGDKKVVFIYHTHNTESYLPLLKGETDPDMARHSKANVTLVG DMFGQALESQGIGATVNKTDIQSKLNKKGLNYARSYDESRPVVKDALASNKNLQYIID IHRDSRRKKDTTATIKGKSYARVAFVVGKKSKNFEENYKIASELHKLMEKKYPGLSTG VFSKGSPGDNGVYNQDLTDRALLLEFGGVDNNLEELQRAANAAADVFSEMYWDAEKVN AASGETKKQ*" /label="spoIIP CDS" gene complement(2302652..2303857) /gene="spoIIP" /locus_tag="BSU_25530" /old_locus_tag="BSU25530" /label="spoIIP gene" promotor_-10 complement(2303877..2303895) /Source="Nicolas_upshift_promotors" /id="U1986" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.58941058941059" /psig="0.58941058941059" /xcortree=451 /SigmaFactorBS="caagaaaacaaaggctcctacaatcactaaacaGTTCTActt cctctagcttgtTCATAGAGTAATTACTAGAcaagcgctggagggattcaatgagaaa t" /listShort="spoIIP, yqxA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2303889) /Source="Nicolas_upshifts" /id="U1986" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.58941058941059" /psig="0.58941058941059" /xcortree=451 /SigmaFactorBS="caagaaaacaaaggctcctacaatcactaaacaGTTCTActt cctctagcttgtTCATAGAGTAATTACTAGAcaagcgctggagggattcaatgagaaa t" /listShort="spoIIP, yqxA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2303911..2303916) /Source="Nicolas_upshift_promotors" /id="U1986" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.58941058941059" /psig="0.58941058941059" /xcortree=451 /SigmaFactorBS="caagaaaacaaaggctcctacaatcactaaacaGTTCTActt cctctagcttgtTCATAGAGTAATTACTAGAcaagcgctggagggattcaatgagaaa t" /listShort="spoIIP, yqxA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2303920..2305026) /gene="gpr" /locus_tag="BSU_25540" /old_locus_tag="BSU25540" /EC_number="3.4.24.78" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10666631, 10986255, 12807468, 23927687" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10666631, 10986255, 12807468, 23927687; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination protease" /protein_id="NP_390432.1" /db_xref="EnsemblGenomes-Gn:BSU25540" /db_xref="EnsemblGenomes-Tr:CAB14496" /db_xref="GOA:P22322" /db_xref="InterPro:IPR005080" /db_xref="InterPro:IPR023430" /db_xref="SubtiList:BG10438" /db_xref="UniProtKB/Swiss-Prot:P22322" /translation="MKKSELDVNQYLIRTDLAVETKEAMANQQAVPTKEIKGFIEKER DHGGIKIRTVDVTKEGAELSGKKEGRYLTLEAQGIRENDSEMQEKVSAVFAEEFSAFL ENLNISKDASCLIVGLGNWNVTPDALGPMAVENLLVTRHLFKLQPENVQEGYRPVSAF APGVMGITGIETSDIIKGVIEQSKPDFVIAIDALAARAVERVNTTIQISDTGIHPGSG VGNKRKDLSKDTLGVPVIAIGVPTVVDAVTIASDTVDYILKHFGREMKDNRPSRSLVP AGMTFGKKKVLTEDDLPDQKQRQSFLGIVGTLQEDEKRQLIHEVLSPLGHNLMVTPKE VDSFIDDMANVLANGLNTALHEKVSQENKGSYNH*" /label="gpr CDS" gene complement(2303920..2305026) /gene="gpr" /locus_tag="BSU_25540" /old_locus_tag="BSU25540" /label="gpr gene" promotor_-10 complement(2305054..2305065) /Source="Nicolas_upshift_promotors" /id="U1987" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1139 /SigmaFactorBS="aatgtaaagtatttttcattgaaggttctctttttAGCATGA tttattcagcaaatGGCAACAATATAggtacttaatgtgaaggaggcccctgtatgaa a" /listShort="gpr, spoIIP, yqxA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2305061) /Source="Nicolas_upshifts" /id="U1987" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1139 /SigmaFactorBS="aatgtaaagtatttttcattgaaggttctctttttAGCATGA tttattcagcaaatGGCAACAATATAggtacttaatgtgaaggaggcccctgtatgaa a" /listShort="gpr, spoIIP, yqxA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2305080..2305086) /Source="Nicolas_upshift_promotors" /id="U1987" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1139 /SigmaFactorBS="aatgtaaagtatttttcattgaaggttctctttttAGCATGA tttattcagcaaatGGCAACAATATAggtacttaatgtgaaggaggcccctgtatgaa a" /listShort="gpr, spoIIP, yqxA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2305125..2305128 /Source="Nicolas_upshift_promotors" /id="U1988" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2636 /SigmaFactorBS="catgctaaaaagagaaccttcaatgaaaaatactttacattt atATTGcaatctaaaggtgtgTTTGATAGAATACAATTTGTtctattgtgaagaagat t" /listShort="S961, rpsT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2305141 /Source="Nicolas_upshifts" /id="U1988" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2636 /SigmaFactorBS="catgctaaaaagagaaccttcaatgaaaaatactttacattt atATTGcaatctaaaggtgtgTTTGATAGAATACAATTTGTtctattgtgaagaagat t" /listShort="S961, rpsT" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2305144..2305163 /Source="Nicolas_upshift_promotors" /id="U1988" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2636 /SigmaFactorBS="catgctaaaaagagaaccttcaatgaaaaatactttacattt atATTGcaatctaaaggtgtgTTTGATAGAATACAATTTGTtctattgtgaagaagat t" /listShort="S961, rpsT" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2305155..2305229 /Source="Nicolas_S_feature" /locus_tag="new_2635740_2635814" /HighExp="HiTm, LPhT, UNK1, HiOs, dia5, aero, MG 15, SMM, Lbtran, MG 45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S961" CDS 2305230..2305496 /gene="rpsT" /locus_tag="BSU_25550" /old_locus_tag="BSU25550" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 16629673, 23002217" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16629673, 23002217; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S20 (BS20)" /protein_id="NP_390433.2" /db_xref="EnsemblGenomes-Gn:BSU25550" /db_xref="EnsemblGenomes-Tr:CAB14497" /db_xref="GOA:P21477" /db_xref="InterPro:IPR002583" /db_xref="InterPro:IPR036510" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11643" /db_xref="UniProtKB/Swiss-Prot:P21477" /translation="MPNIKSAIKRTKTNNERRVHNATIKSAMRTAIKQVEASVANNEA DKAKTALTEAAKRIDKAVKTGLVHKNTAARYKSRLAKKVNGLSA*" /label="rpsT CDS" gene 2305230..2305496 /gene="rpsT" /locus_tag="BSU_25550" /old_locus_tag="BSU25550" /label="rpsT gene" downshifts 2305485 /Source="Nicolas_upshifts" /id="D1321" /incds=0 /nref=244 /ntot=274 /MaxReadThrough="2.22204" /MaxDrop="8.54705" /score="33.3621187" /energy="-12.3" /TU="NA" /idTUdmin="U1988" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2305511..2306554) /gene="holA" /locus_tag="BSU_25560" /old_locus_tag="BSU25560" /EC_number="2.7.7.7" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:9434186, 11432857, 12060778, 12682299, 22333191, 23525462" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9434186, 11432857, 12060778, 12682299, 22333191, 23525462; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase clamp loader delta subunit" /protein_id="NP_390434.1" /db_xref="EnsemblGenomes-Gn:BSU25560" /db_xref="EnsemblGenomes-Tr:CAB14498" /db_xref="GOA:P54459" /db_xref="InterPro:IPR005790" /db_xref="InterPro:IPR008921" /db_xref="InterPro:IPR010372" /db_xref="InterPro:IPR027417" /db_xref="PDB:3ZH9" /db_xref="SubtiList:BG11642" /db_xref="UniProtKB/Swiss-Prot:P54459" /translation="MVFDVWKSLKKGEVHPVYCLYGKETYLLQETVSRIRQTVVDQET KDFNLSVFDLEEDPLDQAIADAETFPFMGERRLVIVKNPYFLTGEKKKEKIEHNVSAL ESYIQSPAPYTVFVLLAPYEKLDERKKLTKALKKHAFMMEAKELNAKETTDFTVNLAK TEQKTIGTEAAEHLVLLVNGHLSSIFQEIQKLCTFIGDREEITLDDVKMLVARSLEQN IFELINKIVNRKRTESLQIFYDLLKQNEEPIKIMALISNQFRLILQTKYFAEQGYGQK QIASNLKVHPFRVKLAMDQARLFSEEELRLIIEQLAVMDYEMKTGKKDKQLLLELFLL QLLKRNEKNDPHY*" /label="holA CDS" gene complement(2305511..2306554) /gene="holA" /locus_tag="BSU_25560" /old_locus_tag="BSU25560" /label="holA gene" downshifts complement(2305556) /Source="Nicolas_upshifts" /id="D1322" /incds=0 /nref=14 /ntot=198 /MaxReadThrough="1.76478" /MaxDrop="4.34213" /score="-1.12561483" /energy="-8.1" /TU="NA" /idTUdmin="U1989" /TUdmin=5 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2306583..2306602) /Source="Nicolas_upshift_promotors" /id="U1989" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.519480519480519" /psig="0.953046953046953" /xcortree=2159 /SigmaFactorBS="ttaatataaatggggaagcagcagtcaggcttcctCTTTAct attttgcaaacTCAATTTAGGATAGAAGGGGatgatgaaagagaggaagtcgtacaac a" /listShort="holA" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2306594..2306743) /locus_tag="BSU_25565" /old_locus_tag="BSU25565" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513978.1" /translation="MKNLEAKVTFSVLVIIAFLQAVPGACEQAFNINGEAAVRLPLYY FANSI*" /label="hypothetical protein CDS" gene complement(2306594..2306743) /locus_tag="BSU_25565" /old_locus_tag="BSU25565" /label="gene" upshifts complement(2306595) /Source="Nicolas_upshifts" /id="U1989" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.519480519480519" /psig="0.953046953046953" /xcortree=2159 /SigmaFactorBS="ttaatataaatggggaagcagcagtcaggcttcctCTTTAct attttgcaaacTCAATTTAGGATAGAAGGGGatgatgaaagagaggaagtcgtacaac a" /listShort="holA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2306616..2306620) /Source="Nicolas_upshift_promotors" /id="U1989" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.519480519480519" /psig="0.953046953046953" /xcortree=2159 /SigmaFactorBS="ttaatataaatggggaagcagcagtcaggcttcctCTTTAct attttgcaaacTCAATTTAGGATAGAAGGGGatgatgaaagagaggaagtcgtacaac a" /listShort="holA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2306618..2306957) /Source="Nicolas_S_feature" /locus_tag="new_2637203_2637542_c" /HighExp="S8, S6, S7, BT, S5, C30, Pyr, G/S, B36, GM 150" /AntisenseName="yqzM" /AntisenseCor="-2.0369593011890001E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA" /TUshortPSig="1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S962" downshifts complement(2306661) /Source="Nicolas_upshifts" /id="D1323" /incds=0 /nref=4 /ntot=37 /MaxReadThrough="5.04584" /MaxDrop="3.298" /score="-1.12561483" /energy="-8.1" /TU="U1991,U1995" /idTUdmin="U1992" /TUdmin=748 /isTUend="FALSE" /label="downshifts" promotor_-35 2306730..2306736 /Source="Nicolas_upshift_promotors" /id="U1990" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.405594405594406" /psig=1 /xcortree=421 /SigmaFactorBS="aaggcgataatcaccagaacagaaaacgttaccttagctTCT AGATttttcaaaacaatTCCATTATACTTAAGTCAGTcaggagggataaagttgaatg a" /listShort="yqzM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2306750..2306769 /Source="Nicolas_upshift_promotors" /id="U1990" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.405594405594406" /psig=1 /xcortree=421 /SigmaFactorBS="aaggcgataatcaccagaacagaaaacgttaccttagctTCT AGATttttcaaaacaatTCCATTATACTTAAGTCAGTcaggagggataaagttgaatg a" /listShort="yqzM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2306751 /Source="Nicolas_upshifts" /id="U1990" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.405594405594406" /psig=1 /xcortree=421 /SigmaFactorBS="aaggcgataatcaccagaacagaaaacgttaccttagctTCT AGATttttcaaaacaatTCCATTATACTTAAGTCAGTcaggagggataaagttgaatg a" /listShort="yqzM" /GFF_Attribute="listLong" /label="upshifts" CDS 2306784..2306918 /gene="yqzM" /locus_tag="BSU_25569" /old_locus_tag="BSU25569" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097762.1" /db_xref="EnsemblGenomes-Gn:BSU25569" /db_xref="EnsemblGenomes-Tr:CAX52662" /db_xref="GOA:C0H453" /db_xref="InterPro:IPR025416" /db_xref="UniProtKB/Swiss-Prot:C0H453" /translation="MNDFEKNVQSKRNDAVDSAVGFVVSFGFFAFLFVMATVIHLVGS *" /label="yqzM CDS" gene 2306784..2306918 /gene="yqzM" /locus_tag="BSU_25569" /old_locus_tag="BSU25569" /label="yqzM gene" downshifts 2306912 /Source="Nicolas_upshifts" /id="D1324" /incds=0 /nref=156 /ntot=250 /MaxReadThrough="3.51266" /MaxDrop="6.2258" /score="20.1810918" /energy="-12.1" /TU="U1990" /idTUdmin="U1990" /TUdmin="-465" /isTUend="FALSE" /label="downshifts" CDS complement(2306958..2309288) /gene="comEC" /locus_tag="BSU_25570" /old_locus_tag="BSU25570" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12123453, 15661011, 16751195, 17630974, 21397556, 27318187" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12123453, 15661011, 16751195, 17630974, 21397556, 27318187; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="DNA channel for uptake in competent cells" /protein_id="NP_390435.1" /db_xref="EnsemblGenomes-Gn:BSU25570" /db_xref="EnsemblGenomes-Tr:CAB14499" /db_xref="GOA:P39695" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR004477" /db_xref="InterPro:IPR004797" /db_xref="InterPro:IPR025405" /db_xref="InterPro:IPR035681" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG10482" /db_xref="UniProtKB/Swiss-Prot:P39695" /translation="MRNSRLLLPMAAASATAGITAAAYFPAIFLFILFLLIILIKTRH AFLIIVCFFSFILFFVLYAVTDSQNVSSYRQGTYQFKAVIDTIPKIDGDRMSMMVETP DKEKWAAAYRIQSAGEKEQLLYIEPGMSCELTGTLEEPNHATVPGAFDYNEYLYRQHI HWNYSVTSIQNCSEPENFKYKVLSLRKHIISFTNSLLPPDSTGIVQALTVGDRFYVED EVLTAYQKLGVVHLLAISGLHVGILTAGLFYIMIRLGITREKASILLLLFLPLYVMLT GAAPSVLRAALMSGVYLAGSLVKWRVRSATAICLSYIVLLLFNPYHLFEAGFQLSFAV SFSLILSSSIFQQVKTSLGQLTIVSLIAQLGSLPILLYHFHQFSIISVPMNMLMVPFY TFCILPGAVAGVLLLSLSASFGRLFFSWFDLLISWINRLITNIADVDVFTIMIAHPAP VLLFLFTVTIILLLMAIEKRSLSQLMVTGGICCTVMFLLFIYPCLSSEGEVDMIDIGQ GDSMFVGAPHQRGRVLIDTGGTLSYSSEPWREKQHPFSLGEKVLIPFLTAKGIKQLDA LILTHADQDHIGEAEILLKHHKVKRLVIPKGFVSEPKDEKVLQAAREEGVAIEEVKRG DVLQIKDLQFHVLSPEAPDPASKNNSSLVLWMETGGMSWILTGDLEKEGEQEVMNVFP NIKADVLKVGHHGSKGSTGEEFIQQLQPKTAIISAGKNNRYHHPHQKVLQLLQRHSIR VLRTDQNGTIQYRYKNRVGTFSVYPPYDTSDITETN*" /label="comEC CDS" gene complement(2306958..2309288) /gene="comEC" /locus_tag="BSU_25570" /old_locus_tag="BSU25570" /label="comEC gene" promotor_-10 complement(2306975..2306994) /Source="Nicolas_upshift_promotors" /id="U1991" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1328 /SigmaFactorBS="aaacggaacgatccaatatagatacaaaaacagaGTTGGAAC CTtttctgtctatccTCCATATGATACATCAGATAtaacagagacgaactaaaaaaga c" /listShort="S962, holA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2306991) /Source="Nicolas_upshifts" /id="U1991" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1328 /SigmaFactorBS="aaacggaacgatccaatatagatacaaaaacagaGTTGGAAC CTtttctgtctatccTCCATATGATACATCAGATAtaacagagacgaactaaaaaaga c" /listShort="S962, holA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2307008..2307017) /Source="Nicolas_upshift_promotors" /id="U1991" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1328 /SigmaFactorBS="aaacggaacgatccaatatagatacaaaaacagaGTTGGAAC CTtttctgtctatccTCCATATGATACATCAGATAtaacagagacgaactaaaaaaga c" /listShort="S962, holA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2309292..2309861) /gene="comEB" /locus_tag="BSU_25580" /old_locus_tag="BSU25580" /EC_number="3.5.4.12" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 7768800, 26416910; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="dCMP deaminase associated to DNA transport (competence)" /protein_id="NP_390436.1" /db_xref="EnsemblGenomes-Gn:BSU25580" /db_xref="EnsemblGenomes-Tr:CAB14500" /db_xref="GOA:P32393" /db_xref="InterPro:IPR002125" /db_xref="InterPro:IPR013404" /db_xref="InterPro:IPR015517" /db_xref="InterPro:IPR016192" /db_xref="InterPro:IPR016193" /db_xref="InterPro:IPR016473" /db_xref="InterPro:IPR035105" /db_xref="SubtiList:BG10481" /db_xref="UniProtKB/Swiss-Prot:P32393" /translation="MERISWNQYFMAQSHLLALRSTCPRLSVGATIVRDKRMIAGGYN GSIAGGVHCADEGCLMIDDHCARTIHAEMNAILQCSKFGVPTDGAEIYVTHYPCIQCC KSIIQAGIKTVYYAEDYKTHPYAQELFEQAGVTVEQVELDEMIVDLKNREKLSFVAGL IGKLADAGLAEEELKKIHEQANTLFTSYV*" /label="comEB CDS" gene complement(2309292..2309861) /gene="comEB" /locus_tag="BSU_25580" /old_locus_tag="BSU25580" /label="comEB gene" promotor_-10 complement(2309888..2309907) /Source="Nicolas_upshift_promotors" /id="U1992" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=1881 /SigmaFactorBS="gaaaataaagtcttccattacagtaaagtGATTTGACggtca tgcattatgATAGGTAAACTAAAGGTCAGgcaacacaacatttggagggaacaacgtg g" /listShort="comEB, comEC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2309898) /Source="Nicolas_upshifts" /id="U1992" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=1881 /SigmaFactorBS="gaaaataaagtcttccattacagtaaagtGATTTGACggtca tgcattatgATAGGTAAACTAAAGGTCAGgcaacacaacatttggagggaacaacgtg g" /listShort="comEB, comEC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2309922..2309929) /Source="Nicolas_upshift_promotors" /id="U1992" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=1881 /SigmaFactorBS="gaaaataaagtcttccattacagtaaagtGATTTGACggtca tgcattatgATAGGTAAACTAAAGGTCAGgcaacacaacatttggagggaacaacgtg g" /listShort="comEB, comEC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2309928..2310545) /gene="comEA" /locus_tag="BSU_25590" /old_locus_tag="BSU25590" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16751195, 21278288, 22398145, 25727469" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16751195, 21278288, 22398145, 25727469; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="membrane bound high-affinity DNA-binding receptor" /protein_id="NP_390437.1" /db_xref="EnsemblGenomes-Gn:BSU25590" /db_xref="EnsemblGenomes-Tr:CAB14501" /db_xref="GOA:P39694" /db_xref="InterPro:IPR003583" /db_xref="InterPro:IPR004509" /db_xref="InterPro:IPR004787" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR019554" /db_xref="SubtiList:BG10480" /db_xref="UniProtKB/Swiss-Prot:P39694" /translation="MNWLNQHKKAIILAASAAVFTAIMIFLATGKNKEPVKQAVPTET ENTVVKQEANNDESNETIVIDIKGAVQHPGVYEMRTGDRVSQAIEKAGGTSEQADEAQ VNLAEILQDGTVVYIPKKGEETAVQQGGGGSVQSDGGKGALVNINTATLEELQGISGV GPSKAEAIIAYREENGRFQTIEDITKVSGIGEKSFEKIKSSITVK*" /label="comEA CDS" gene complement(2309928..2310545) /gene="comEA" /locus_tag="BSU_25590" /old_locus_tag="BSU25590" /label="comEA gene" promotor_-35 2310566..2310571 /Source="Nicolas_upshift_promotors" /id="U1993" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1103 /SigmaFactorBS="ttatgctgattcaaccaattcatcgtgcatgttccccgcttt cGTCATAttttattttcataacACATATGGTTTAGAGGATAatagctcaaaggagggg a" /listShort="comER" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2310583 /Source="Nicolas_upshifts" /id="U1993" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1103 /SigmaFactorBS="ttatgctgattcaaccaattcatcgtgcatgttccccgcttt cGTCATAttttattttcataacACATATGGTTTAGAGGATAatagctcaaaggagggg a" /listShort="comER" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2310587..2310605 /Source="Nicolas_upshift_promotors" /id="U1993" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1103 /SigmaFactorBS="ttatgctgattcaaccaattcatcgtgcatgttccccgcttt cGTCATAttttattttcataacACATATGGTTTAGAGGATAatagctcaaaggagggg a" /listShort="comER" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2310606..2310620) /Source="Nicolas_upshift_promotors" /id="U1994" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=681 /SigmaFactorBS="tcgtacccatatttcctgtgccgataaagcctatcTTCAAtg gtttccCCTCCTTTGAGCTATtatcctctaaaccatatgtgttatgaaaataaaatat g" /listShort="comEA, comEB, comEC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2310608) /Source="Nicolas_upshifts" /id="U1994" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=681 /SigmaFactorBS="tcgtacccatatttcctgtgccgataaagcctatcTTCAAtg gtttccCCTCCTTTGAGCTATtatcctctaaaccatatgtgttatgaaaataaaatat g" /listShort="comEA, comEB, comEC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2310610..2311457) /Source="Nicolas_S_feature" /locus_tag="new_2641195_2642042_c" /HighExp="C30, T0.30H, T-2.40H, GM 150, T1.30H, T-0.40H, T-1.10H, T-1.40H, T1.0H, T0.0H" /AntisenseName="comER" /AntisenseCor="-8.2389039371154299E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S963" promotor_-35 complement(2310629..2310633) /Source="Nicolas_upshift_promotors" /id="U1994" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=681 /SigmaFactorBS="tcgtacccatatttcctgtgccgataaagcctatcTTCAAtg gtttccCCTCCTTTGAGCTATtatcctctaaaccatatgtgttatgaaaataaaatat g" /listShort="comEA, comEB, comEC" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2310629..2311450 /gene="comER" /locus_tag="BSU_25600" /old_locus_tag="BSU25600" /EC_number="1.5.1.2" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7968523, 11418582, 27446060, 28824574; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative pyrroline-5'-carboxylate reductase" /protein_id="NP_390438.1" /db_xref="EnsemblGenomes-Gn:BSU25600" /db_xref="EnsemblGenomes-Tr:CAB14502" /db_xref="GOA:P39696" /db_xref="InterPro:IPR000304" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR028939" /db_xref="InterPro:IPR029036" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10479" /db_xref="UniProtKB/Swiss-Prot:P39696" /translation="MKIGFIGTGNMGTILIESFIESKAADPSNMTITNRTIEKALHIK NRYNSINVTESLEKLVSENEMIFICVKPLDIYPLLARALPYLRKDHILISITSPVQTE QLEQYVPCQVARVIPSITNRALAGVSLVTFGTSCGESAKAKINELMQHISHPLQIESD ITRVASDIVSCGPAFMSYLIQRFIDAAVSETSVSKQDAILMCKEMLVGMGKLLETELY TLPALQEKVCVKGGVTGEGIKALESGVQDMFHRVFQNTHMKYEEDISAVKKQFHV*" /label="comER CDS" gene 2310629..2311450 /gene="comER" /locus_tag="BSU_25600" /old_locus_tag="BSU25600" /label="comER gene" promotor_-10 complement(2311445..2311464) /Source="Nicolas_upshift_promotors" /id="U1995" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.95104895104895" /psig="0.996003996003996" /xcortree=2968 /SigmaFactorBS="taaaacgatggttttttaaaatgcttttttatgCTTTTGCAg tacagacgaacgTATGACATACTCGTCTACACatgaaactgctttttcactgcggaaa t" /listShort="S963, comEA, comEB, comEC, S962, holA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2311451..2311531 /Source="Nicolas_S_feature" /locus_tag="new_2642036_2642116" /HighExp="S4, S5, S3, S6, S7, B36, Pyr, G/S, S8, BT" /AntisenseName="yqeM" /AntisenseCor="-0.52267300854840604" /AntisenseRegPval="-19.5" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S964" upshifts complement(2311458) /Source="Nicolas_upshifts" /id="U1995" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.95104895104895" /psig="0.996003996003996" /xcortree=2968 /SigmaFactorBS="taaaacgatggttttttaaaatgcttttttatgCTTTTGCAg tacagacgaacgTATGACATACTCGTCTACACatgaaactgctttttcactgcggaaa t" /listShort="S963, comEA, comEB, comEC, S962, holA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2311478..2311485) /Source="Nicolas_upshift_promotors" /id="U1995" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.95104895104895" /psig="0.996003996003996" /xcortree=2968 /SigmaFactorBS="taaaacgatggttttttaaaatgcttttttatgCTTTTGCAg tacagacgaacgTATGACATACTCGTCTACACatgaaactgctttttcactgcggaaa t" /listShort="S963, comEA, comEB, comEC, S962, holA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2311491 /Source="Nicolas_upshifts" /id="D1325" /incds=0 /nref=45 /ntot=64 /MaxReadThrough="2.4803" /MaxDrop="5.1403" /score="7.09525061" /energy="-10.5" /TU="NA" /idTUdmin="U1993" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2311516..2312259) /gene="yqeM" /locus_tag="BSU_25610" /old_locus_tag="BSU25610" /EC_number="2.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative methyltransferase" /protein_id="NP_390439.1" /db_xref="EnsemblGenomes-Gn:BSU25610" /db_xref="EnsemblGenomes-Tr:CAB14503" /db_xref="GOA:P54458" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11641" /db_xref="UniProtKB/Swiss-Prot:P54458" /translation="MIYQGFASVYDELMSHAPYDQWTKWIEASLPEKGRILDLACGTG EISIRLAEKGFEVTGIDLSEEMLSFAQQKVSSSQPILFLQQDMREITGFDGQFDAVVI CCDSLNYLKTKNDVIETFKSVFRVLKPEGILLFDVHSSFKIAEVFPDSTFADQDEDIS YIWQSFAGSDELSVIHDMSFFVWNGEAYDRFDETHEQRTFPVEEYEEMLKNCGFQLHR VTADFTDTEPSAQSERLFFKAQKSKTIVS*" /label="yqeM CDS" gene complement(2311516..2312259) /gene="yqeM" /locus_tag="BSU_25610" /old_locus_tag="BSU25610" /label="yqeM gene" downshifts complement(2311546) /Source="Nicolas_upshifts" /id="D1326" /incds=0 /nref=144 /ntot=230 /MaxReadThrough="1.41467" /MaxDrop="5.51802" /score="7.9251293" /energy="-10.5" /TU="NA" /idTUdmin="U1996" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2312256..2312612) /gene="rsfS" /locus_tag="BSU_25620" /old_locus_tag="BSU25620" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15044829, 16980477, 22238375, 22238376, 22829778, 26299947; Product type f : factor" /codon_start=1 /transl_table=11 /product="ribosomal silencing factor" /protein_id="NP_390440.1" /db_xref="EnsemblGenomes-Gn:BSU25620" /db_xref="EnsemblGenomes-Tr:CAB14504" /db_xref="GOA:P54457" /db_xref="InterPro:IPR004394" /db_xref="SubtiList:BG11640" /db_xref="UniProtKB/Swiss-Prot:P54457" /translation="MNQKSILKIAAAACDDKRAEDILALDMEGISLVADYFLICHGNS DKQVQAIAREIKDQADENGIQVKKMEGFDEARWVLVDLGDVVVHVFHKDERSYYNLEK LWGDAPLADLDFGMNQ*" /label="rsfS CDS" gene complement(2312256..2312612) /gene="rsfS" /locus_tag="BSU_25620" /old_locus_tag="BSU25620" /label="rsfS gene" CDS complement(2312630..2313190) /gene="yqeK" /locus_tag="BSU_25630" /old_locus_tag="BSU25630" /function="16.2: Construct biomass (Anabolism)" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15175311, 22333191; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390441.1" /db_xref="EnsemblGenomes-Gn:BSU25630" /db_xref="EnsemblGenomes-Tr:CAB14505" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR005249" /db_xref="InterPro:IPR006674" /db_xref="SubtiList:BG11639" /db_xref="UniProtKB/Swiss-Prot:P54456" /translation="MNREEALACVKQQLTEHRYIHTVGVMNTAIELAERFGADSKKAE IAAIFHDYAKFRPKEEMKQIIAREKMPAHLLDHNPELWHAPVGAYLVQREAGVQDEDI LDAIRYHTSGRPGMTLLEKVIYVADYIEPNRAFPGVDEVRKLAETDLNQALIQSIKNT MVFLMKKNQPVFPDTFLTYNWLVSGS*" /label="yqeK CDS" gene complement(2312630..2313190) /gene="yqeK" /locus_tag="BSU_25630" /old_locus_tag="BSU25630" /label="yqeK gene" CDS complement(2313180..2313749) /gene="nadD" /locus_tag="BSU_25640" /old_locus_tag="BSU25640" /EC_number="2.7.7.18" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11704676, 12682299, 19716475, 23204464, 25631047; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nicotinate-nucleotide adenylyltransferase" /protein_id="NP_390442.1" /db_xref="EnsemblGenomes-Gn:BSU25640" /db_xref="EnsemblGenomes-Tr:CAB14506" /db_xref="GOA:P54455" /db_xref="InterPro:IPR004821" /db_xref="InterPro:IPR005248" /db_xref="InterPro:IPR014729" /db_xref="PDB:1KAM" /db_xref="PDB:1KAQ" /db_xref="SubtiList:BG11638" /db_xref="UniProtKB/Swiss-Prot:P54455" /translation="MKKIGIFGGTFDPPHNGHLLMANEVLYQAGLDEIWFMPNQIPPH KQNEDYTDSFHRVEMLKLAIQSNPSFKLELVEMEREGPSYTFDTVSLLKQRYPNDQLF FIIGADMIEYLPKWYKLDELLNLIQFIGVKRPGFHVETPYPLLFADVPEFEVSSTMIR ERFKSKKPTDYLIPDKVKKYVEENGLYES*" /label="nadD CDS" gene complement(2313180..2313749) /gene="nadD" /locus_tag="BSU_25640" /old_locus_tag="BSU25640" /label="nadD gene" CDS complement(2313761..2314051) /gene="yqeI" /locus_tag="BSU_25650" /old_locus_tag="BSU25650" /experiment="publication(s) with functional evidences, PMID:12682299, 16014871, 17005971, 17105995" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16014871, 17005971, 17105995; Product type f: factor" /codon_start=1 /transl_table=11 /product="50S RNA-binding protein" /protein_id="NP_390443.1" /db_xref="EnsemblGenomes-Gn:BSU25650" /db_xref="EnsemblGenomes-Tr:CAB14507" /db_xref="GOA:P54454" /db_xref="InterPro:IPR001890" /db_xref="InterPro:IPR017924" /db_xref="InterPro:IPR035920" /db_xref="SubtiList:BG11637" /db_xref="UniProtKB/Swiss-Prot:P54454" /translation="MLTGKQKRFLRSKAHHLTPIFQVGKGGVNDNMIKQIAEALEARE LIKVSVLQNCEEDKNDVAEALVKGSRSQLVQTIGNTIVLYKESKENKQIELP*" /label="yqeI CDS" gene complement(2313761..2314051) /gene="yqeI" /locus_tag="BSU_25650" /old_locus_tag="BSU25650" /label="yqeI gene" CDS complement(2314045..2314887) /gene="aroE" /locus_tag="BSU_25660" /old_locus_tag="BSU25660" /EC_number="1.1.1.25" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2104604, 12906820, 22938038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="shikimate 5-dehydrogenase" /protein_id="NP_390444.2" /db_xref="EnsemblGenomes-Gn:BSU25660" /db_xref="EnsemblGenomes-Tr:CAB14508" /db_xref="GOA:P54374" /db_xref="InterPro:IPR006151" /db_xref="InterPro:IPR011342" /db_xref="InterPro:IPR013708" /db_xref="InterPro:IPR022893" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11522" /db_xref="UniProtKB/Swiss-Prot:P54374" /translation="MKKLYGVIGNPIGHSMSPDIHNASLKDLGLDGHYHAFKVEENDL EDAVKGIRALGVQGINVTVPHKVSIMDYLDHIDESAKVLGAVNTVRREGDKLVGYNTD GEGFVKSLMKVLDKPISELSFLMIGAGGAARAIFTTIVRNTPKKFDICNRTLEKAKRL TEATPSFHNKEVLSIKEAEERLEQYDVIIHTTSVGMYPNVDDVPLSLQRAASSAVVCD IVYNPIQTALLKEASQKGLKTLDGVGMFVEQAALSFQLWTGQEPNIEKMRSIVIGKLG GTEC*" /label="aroE CDS" gene complement(2314045..2314887) /gene="aroE" /locus_tag="BSU_25660" /old_locus_tag="BSU25660" /label="aroE gene" downshifts 2314879 /Source="Nicolas_upshifts" /id="D1327" /incds=0 /nref=2 /ntot=118 /MaxReadThrough="0.240279999999999" /MaxDrop="3.04009" /score="0.0642154872" /energy="-17" /TU="NA" /idTUdmin="U1993" /TUdmin=3388 /isTUend="FALSE" /label="downshifts" CDS complement(2314905..2316005) /gene="rgpH" /locus_tag="BSU_25670" /old_locus_tag="BSU25670" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12427945, 12682299, 17237168, 17895579, 18801747, 19540197, 20376346, 22750478" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12427945, 12682299, 17237168, 17895579, 18801747, 19540197, 20376346, 22750478; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="potassium-dependent GTPase involved in ribosome 30S assembly" /protein_id="NP_390445.1" /db_xref="EnsemblGenomes-Gn:BSU25670" /db_xref="EnsemblGenomes-Tr:CAB14509" /db_xref="GOA:P54453" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR019988" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030378" /db_xref="SubtiList:BG11636" /db_xref="UniProtKB/Swiss-Prot:P54453" /translation="MEKVVCIGCGVTIQTEDKTGLGYAPPASLTKENVICQRCFRLKN YNEIQDVSLTDDDFLNILHGIGETDSLVVKIVDIFDFNGSWINGLQRLVGGNPILLVG NKADILPKSLKRERLIQWMKREAKELGLKPVDVFLVSAGRGQGIREVIDAIEHYRNGK DVYVVGCTNVGKSTFINRIIKEVSGEEDIITTSQFPGTTLDAIEIPLDDGSSLYDTPG IINNHQMAHYVNKKDLKILSPKKELKPRTFQLNDQQTLYFGGLARFDYVSGERSPFIC YMPNELMIHRTKLENADALYEKHAGELLTPPGKDEMDEFPELVAHTFTIKDKKTDIVF SGLGWVTVHDADKKVTAYAPKGVHVFVRRSLI*" /label="rgpH CDS" gene complement(2314905..2316005) /gene="rgpH" /locus_tag="BSU_25670" /old_locus_tag="BSU25670" /label="rgpH gene" CDS complement(2316009..2316527) /gene="yqeG" /locus_tag="BSU_25680" /old_locus_tag="BSU25680" /EC_number="3.1.3.-" /experiment="publication(s) with functional evidences, PMID:27784292" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 27784292; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphatase (active on GMP and Glc-6-P)" /protein_id="NP_390446.1" /db_xref="EnsemblGenomes-Gn:BSU25680" /db_xref="EnsemblGenomes-Tr:CAB14510" /db_xref="GOA:P54452" /db_xref="InterPro:IPR006356" /db_xref="InterPro:IPR006439" /db_xref="InterPro:IPR006549" /db_xref="InterPro:IPR010021" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG11635" /db_xref="UniProtKB/Swiss-Prot:P54452" /translation="MLKKFFLPDEFVKNIFHITPEKLKERNVKGIITDLDNTLVEWDR PNATPRLIEWFEEMKEHGIKVTIVSNNNERRVKLFSEPLGIPFIYKARKPMGKAFNRA VRNMELKKEDCVVIGDQLLTDVLGGNRNGYHTILVVPVASSDGFITRFNRQVERRILS ALKRKGHIQWEE*" /label="yqeG CDS" gene complement(2316009..2316527) /gene="yqeG" /locus_tag="BSU_25680" /old_locus_tag="BSU25680" /label="yqeG gene" promotor_-10 complement(2316437..2316454) /Source="Nicolas_upshift_promotors" /id="U1996" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.415584415584416" /psig="0.415584415584416" /xcortree=2452 /SigmaFactorBS="ttttacctgacgagtttgtaaaaaatatttttcatattACAC ctgagaaattaaaggAACGAAATGTAAAAGGAAttattactgacctggataatacgct t" /listShort="yqeH, aroD, yqeI, nadD, yqeK, yqeL, yqeM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2316451) /Source="Nicolas_upshifts" /id="U1996" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.415584415584416" /psig="0.415584415584416" /xcortree=2452 /SigmaFactorBS="ttttacctgacgagtttgtaaaaaatatttttcatattACAC ctgagaaattaaaggAACGAAATGTAAAAGGAAttattactgacctggataatacgct t" /listShort="yqeH, aroD, yqeI, nadD, yqeK, yqeL, yqeM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2316470..2316473) /Source="Nicolas_upshift_promotors" /id="U1996" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.415584415584416" /psig="0.415584415584416" /xcortree=2452 /SigmaFactorBS="ttttacctgacgagtttgtaaaaaatatttttcatattACAC ctgagaaattaaaggAACGAAATGTAAAAGGAAttattactgacctggataatacgct t" /listShort="yqeH, aroD, yqeI, nadD, yqeK, yqeL, yqeM" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2316528..2317089) /Source="Nicolas_S_feature" /locus_tag="new_2647113_2647674_c" /HighExp="G135, G180, G150, Paraq, Oxctl, C30, Heat, HPh, BMM, LPh" /AntisenseName="sda" /AntisenseCor="-8.6107693225382295E-2" /AntisenseRegPval="-0.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S965" downshifts complement(2316561) /Source="Nicolas_upshifts" /id="D1328" /incds=0 /nref=1 /ntot=1 /MaxReadThrough="6.83118" /MaxDrop="5.26138" /score="9.20556883" /energy="-8.6" /TU="U1998" /idTUdmin="U1999" /TUdmin=616 /isTUend="FALSE" /label="downshifts" promotor_-35 2316752..2316759 /Source="Nicolas_upshift_promotors" /id="U1997" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2945 /SigmaFactorBS="tactcacaagttatccactttttggtgtggataacagaacga TTGTTCTTatatgcatttCATGGTAGATTAAAGATAACttcaacctcagatgaatgca a" /listShort="S966, sda, S967, S969" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2316770..2316870 /Source="Nicolas_S_feature" /locus_tag="new_2647355_2647455" /HighExp="T3.0H, T-0.40H, MG 150, T5.0H, T-1.40H, T4.0H, T2.30H, T0.0H, T3.30H, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S966" promotor_-10 2316770..2316789 /Source="Nicolas_upshift_promotors" /id="U1997" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2945 /SigmaFactorBS="tactcacaagttatccactttttggtgtggataacagaacga TTGTTCTTatatgcatttCATGGTAGATTAAAGATAACttcaacctcagatgaatgca a" /listShort="S966, sda, S967, S969" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2316770 /Source="Nicolas_upshifts" /id="U1997" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2945 /SigmaFactorBS="tactcacaagttatccactttttggtgtggataacagaacga TTGTTCTTatatgcatttCATGGTAGATTAAAGATAACttcaacctcagatgaatgca a" /listShort="S966, sda, S967, S969" /GFF_Attribute="listLong" /label="upshifts" misc_RNA complement(2316820..2317078) /gene="sdaM" /locus_tag="BSU_misc_RNA_80" /product="antisense RNA" /experiment="publication(s) with functional evidences, PMID:20525796" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20525796; Product type n: RNA" /label="sdaM RNA" gene complement(2316820..2317078) /gene="sdaM" /locus_tag="BSU_misc_RNA_80" /label="sdaM gene" CDS 2316871..2317029 /gene="sda" /locus_tag="BSU_25690" /old_locus_tag="BSU25690" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15023339, 16796683, 19040634, 22720735, 28752667" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15023339, 16796683, 19040634, 22720735, 28752667; Product type f: factor" /codon_start=1 /transl_table=11 /product="check point factor coupling initiation of sporulation and replication initiation" /protein_id="YP_054588.1" /db_xref="EnsemblGenomes-Gn:BSU25690" /db_xref="EnsemblGenomes-Tr:CAE01463" /db_xref="GOA:Q7WY62" /db_xref="InterPro:IPR015064" /db_xref="InterPro:IPR036916" /db_xref="PDB:1PV0" /db_xref="PDB:3FYR" /db_xref="SubtiList:BG14183" /db_xref="UniProtKB/Swiss-Prot:Q7WY62" /translation="MNWVPSMRKLSDELLIESYFKATEMNLNRDFIELIENEIKRRSL GHIISVSS*" /label="sda CDS" gene 2316871..2317029 /gene="sda" /locus_tag="BSU_25690" /old_locus_tag="BSU25690" /label="sda gene" S_feature 2317030..2317276 /Source="Nicolas_S_feature" /locus_tag="new_2647615_2647861" /HighExp="Cold, T-0.40H, MG 150, T5.0H, T4.0H, C30, T2.30H, M9-tran, S2, GM 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S967" promotor_-10 complement(2317077..2317096) /Source="Nicolas_upshift_promotors" /id="U1998" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.509490509490509" /psig="0.999000999001" /xcortree=2592 /SigmaFactorBS="cctctttttaggggtgttttttgctgaaaataGTAGTaaagc gcgcagccaaAGTGATATAATATCAGTCATctgagtaaaaaaaggaaatacgcccgga a" /listShort="S965, yqeG, yqeH, aroD, yqeI, nadD, yqeK, yqeL, yqeM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2317088) /Source="Nicolas_upshifts" /id="U1998" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.509490509490509" /psig="0.999000999001" /xcortree=2592 /SigmaFactorBS="cctctttttaggggtgttttttgctgaaaataGTAGTaaagc gcgcagccaaAGTGATATAATATCAGTCATctgagtaaaaaaaggaaatacgcccgga a" /listShort="S965, yqeG, yqeH, aroD, yqeI, nadD, yqeK, yqeL, yqeM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2317112..2317116) /Source="Nicolas_upshift_promotors" /id="U1998" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.509490509490509" /psig="0.999000999001" /xcortree=2592 /SigmaFactorBS="cctctttttaggggtgttttttgctgaaaataGTAGTaaagc gcgcagccaaAGTGATATAATATCAGTCATctgagtaaaaaaaggaaatacgcccgga a" /listShort="S965, yqeG, yqeH, aroD, yqeI, nadD, yqeK, yqeL, yqeM" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2317140..2317287) /Source="Nicolas_S_feature" /locus_tag="new_2647725_2647872_c" /HighExp="S8, S7, S6, Etha, LBGstat, T0.30H, Salt, BT, LPhT, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99948400000000004" /TUshortSig="SigK, SigA, SigB" /TUshortPSig="1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S968" downshifts complement(2317177) /Source="Nicolas_upshifts" /id="D1329" /incds=0 /nref=12 /ntot=92 /MaxReadThrough="2.70676" /MaxDrop="4.386" /score="9.20556883" /energy="-8.6" /TU="NA" /idTUdmin="U1999" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 2317233 /Source="Nicolas_upshifts" /id="D1330" /incds=0 /nref=1 /ntot=126 /MaxReadThrough="5.36291" /MaxDrop="2.1106" /score="10.3636587" /energy="-6.2" /TU="U1997" /idTUdmin="U1997" /TUdmin="-1056" /isTUend="FALSE" /label="downshifts" S_feature 2317278..2318331 /Source="Nicolas_S_feature" /locus_tag="new_2647863_2648916" /HighExp="T-0.40H, Cold, M40t90, T0.0H, C30, Glucon, S2, T1.30H, T2.30H, T2.0H" /AntisenseName="yqeF" /AntisenseCor="-0.39616310996746001" /AntisenseRegPval="-10.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S969" promotor_-10 complement(2317282..2317301) /Source="Nicolas_upshift_promotors" /id="U1999" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1228 /SigmaFactorBS="cctgcagcgttgagccggacaaccGCCTAGTCCGatttattt ctccTACATAGGCTGTTATAAAACcttattaaggaggcgcttcacatgtatggcgcag g" /listShort="S968" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2317287) /Source="Nicolas_upshifts" /id="U1999" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1228 /SigmaFactorBS="cctgcagcgttgagccggacaaccGCCTAGTCCGatttattt ctccTACATAGGCTGTTATAAAACcttattaaggaggcgcttcacatgtatggcgcag g" /listShort="S968" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2317314..2317323) /Source="Nicolas_upshift_promotors" /id="U1999" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1228 /SigmaFactorBS="cctgcagcgttgagccggacaaccGCCTAGTCCGatttattt ctccTACATAGGCTGTTATAAAACcttattaaggaggcgcttcacatgtatggcgcag g" /listShort="S968" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2317335..2318066) /gene="yqeF" /locus_tag="BSU_25700" /old_locus_tag="BSU25700" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lipoprotein; putative esterase" /protein_id="NP_390447.1" /db_xref="EnsemblGenomes-Gn:BSU25700" /db_xref="EnsemblGenomes-Tr:CAB14511" /db_xref="GOA:P54451" /db_xref="InterPro:IPR013830" /db_xref="InterPro:IPR036514" /db_xref="SubtiList:BG11634" /db_xref="UniProtKB/Swiss-Prot:P54451" /translation="MKHFIILFLLLFVTAGCEGRGYEDVVAFGDSNTRGSNWDYRDYP KAQQWVNILKTAERGNLDILNAGIGGQTTEDARLRFQTDVLDQKPKYLFIMFGTNDAA ILTEGKPRVSKQRFRENLVYFIEESRKHGIKPILMTCIPIIEGNGKHHLFYYSRYQAA AFEPKGGARKWHNSYNDITRDVSKRLDVPLVDNWKHFIEADGGKATDEALIQSGLIDP SGNHMTPKGARIVYEGIQDGQILQR*" /label="yqeF CDS" gene complement(2317335..2318066) /gene="yqeF" /locus_tag="BSU_25700" /old_locus_tag="BSU25700" /label="yqeF gene" promotor_-10 complement(2318085..2318104) /Source="Nicolas_upshift_promotors" /id="U2000" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.380619380619381" /psig=1 /xcortree=2739 /SigmaFactorBS="taactataggaaaaaacagtgatagcgaaaaactcttCATTG AAcgaagagaaacagAGGTATAACATTAAAGTGAGgcttttgggggtgtaaagatgaa a" /listShort="yqeF, S968" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2318101) /Source="Nicolas_upshifts" /id="U2000" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.380619380619381" /psig=1 /xcortree=2739 /SigmaFactorBS="taactataggaaaaaacagtgatagcgaaaaactcttCATTG AAcgaagagaaacagAGGTATAACATTAAAGTGAGgcttttgggggtgtaaagatgaa a" /listShort="yqeF, S968" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2318103..2318211) /Source="Nicolas_S_feature" /locus_tag="new_2648688_2648796_c" /HighExp="Etha, Salt, Gly, S8, C30, S7, LPhT, Sw, Heat, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S970" promotor_-35 complement(2318118..2318124) /Source="Nicolas_upshift_promotors" /id="U2000" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.380619380619381" /psig=1 /xcortree=2739 /SigmaFactorBS="taactataggaaaaaacagtgatagcgaaaaactcttCATTG AAcgaagagaaacagAGGTATAACATTAAAGTGAGgcttttgggggtgtaaagatgaa a" /listShort="yqeF, S968" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2318212..2318230) /Source="Nicolas_upshift_promotors" /id="U2001" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=162 /SigmaFactorBS="tttccagtgcggattcaggttattttcttttctttggtttgt gTGTTTTtcagattggaaagaAGGGAATTTTAAAAAATCAtcagctgcgccgcaatga a" /listShort="S970, yqeF, S968" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2318233) /Source="Nicolas_upshifts" /id="U2001" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=162 /SigmaFactorBS="tttccagtgcggattcaggttattttcttttctttggtttgt gTGTTTTtcagattggaaagaAGGGAATTTTAAAAAATCAtcagctgcgccgcaatga a" /listShort="S970, yqeF, S968" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2318245..2318250) /Source="Nicolas_upshift_promotors" /id="U2001" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=162 /SigmaFactorBS="tttccagtgcggattcaggttattttcttttctttggtttgt gTGTTTTtcagattggaaagaAGGGAATTTTAAAAAATCAtcagctgcgccgcaatga a" /listShort="S970, yqeF, S968" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2318318..2319070) /gene="cwlH" /locus_tag="BSU_25710" /old_locus_tag="BSU25710" /EC_number="3.5.1.28" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10515909, 10974124, 15687192" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10515909, 10974124, 15687192; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylmuramoyl-L-alanine amidase" /protein_id="NP_390448.1" /db_xref="EnsemblGenomes-Gn:BSU25710" /db_xref="EnsemblGenomes-Tr:CAB14512" /db_xref="GOA:P54450" /db_xref="InterPro:IPR002477" /db_xref="InterPro:IPR002502" /db_xref="InterPro:IPR036365" /db_xref="InterPro:IPR036366" /db_xref="InterPro:IPR036505" /db_xref="SubtiList:BG11633" /db_xref="UniProtKB/Swiss-Prot:P54450" /translation="MVTIKKDFIPVSNDNRPGYAMAPAYITVHNTANTAKGADAKMHA KFVKNPNTSESWHFTVDDSVIYQHLPIDENGWHAGDGTNGTGNRKSIGIEICENADGD FEKATSNAQWLIRKLMKENNIPLNRVVPHKKWSGKECPRKLLDHWNSFLNGISSSDTP PKETSPSYPLPSGVIKLTSPYRKGTNILQLQKALAVLHFYPDKGAKNNGIDGVYGPKT ANAVKRFQLMNGLTADGIYGPKTKAKLKSKLK*" /label="cwlH CDS" gene complement(2318318..2319070) /gene="cwlH" /locus_tag="BSU_25710" /old_locus_tag="BSU25710" /label="cwlH gene" downshifts complement(2318321) /Source="Nicolas_upshifts" /id="D1331" /incds=0 /nref=4 /ntot=10 /MaxReadThrough="1.29819" /MaxDrop="4.65121" /score="4.6304411" /energy="-10.7" /TU="NA" /idTUdmin="U2003" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2318449..2318455 /Source="Nicolas_upshift_promotors" /id="U2002" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=171 /SigmaFactorBS="ctgttttcggtccgtaaactccatctatgccatTGTTTTTgg ctcccttatcaGGGTAAAAGTGAAGTACAGctaaagccttttgcagctggagaatgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2318469..2318487 /Source="Nicolas_upshift_promotors" /id="U2002" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=171 /SigmaFactorBS="ctgttttcggtccgtaaactccatctatgccatTGTTTTTgg ctcccttatcaGGGTAAAAGTGAAGTACAGctaaagccttttgcagctggagaatgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2318476 /Source="Nicolas_upshifts" /id="U2002" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=171 /SigmaFactorBS="ctgttttcggtccgtaaactccatctatgccatTGTTTTTgg ctcccttatcaGGGTAAAAGTGAAGTACAGctaaagccttttgcagctggagaatgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2319080..2319099) /Source="Nicolas_upshift_promotors" /id="U2003" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.898101898101898" /psig="0.898101898101898" /xcortree=1426 /SigmaFactorBS="caggttaagaacacaattcttttttacctcataaaaaaGGCT GTCCAtctctctgttttcTGCATTCTTATTAATAGGGAgggatagaaatggtaaccat a" /listShort="cwlH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2319099) /Source="Nicolas_upshifts" /id="U2003" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.898101898101898" /psig="0.898101898101898" /xcortree=1426 /SigmaFactorBS="caggttaagaacacaattcttttttacctcataaaaaaGGCT GTCCAtctctctgttttcTGCATTCTTATTAATAGGGAgggatagaaatggtaaccat a" /listShort="cwlH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2319113..2319121) /Source="Nicolas_upshift_promotors" /id="U2003" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.898101898101898" /psig="0.898101898101898" /xcortree=1426 /SigmaFactorBS="caggttaagaacacaattcttttttacctcataaaaaaGGCT GTCCAtctctctgttttcTGCATTCTTATTAATAGGGAgggatagaaatggtaaccat a" /listShort="cwlH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2319165..2319172 /Source="Nicolas_upshift_promotors" /id="U2004" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.694305694305694" /psig=1 /xcortree=1830 /SigmaFactorBS="aggtaaaaaagaattgtgttcttaacctggttttCAGTTGAA cagctgaaatggcaCCAGTTATACTAATTTAGATgacggaggttttgactcctgacat c" /listShort="S971, yqeD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2319187..2319206 /Source="Nicolas_upshift_promotors" /id="U2004" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.694305694305694" /psig=1 /xcortree=1830 /SigmaFactorBS="aggtaaaaaagaattgtgttcttaacctggttttCAGTTGAA cagctgaaatggcaCCAGTTATACTAATTTAGATgacggaggttttgactcctgacat c" /listShort="S971, yqeD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2319191..2319256 /Source="Nicolas_S_feature" /locus_tag="new_2649776_2649841" /HighExp="dia15, H2O2, C30, G180, Heat, S8, Paraq, Oxctl, LBGexp, Etha" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S971" upshifts 2319191 /Source="Nicolas_upshifts" /id="U2004" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.694305694305694" /psig=1 /xcortree=1830 /SigmaFactorBS="aggtaaaaaagaattgtgttcttaacctggttttCAGTTGAA cagctgaaatggcaCCAGTTATACTAATTTAGATgacggaggttttgactcctgacat c" /listShort="S971, yqeD" /GFF_Attribute="listLong" /label="upshifts" CDS 2319257..2319883 /gene="yqeD" /locus_tag="BSU_25720" /old_locus_tag="BSU25720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 15855514, 16850406" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_390449.1" /db_xref="EnsemblGenomes-Gn:BSU25720" /db_xref="EnsemblGenomes-Tr:CAB14513" /db_xref="GOA:P54449" /db_xref="InterPro:IPR015414" /db_xref="InterPro:IPR032816" /db_xref="SubtiList:BG11632" /db_xref="UniProtKB/Swiss-Prot:P54449" /translation="MLKKVIGILVIIAIISVGFFQKEAWLDAIKAGGMFSVLFSMLLI AADVFFPIVPFALIAALNGAVFGTANGIWITLTGSMLGTILLFFLARYSFRDWARKKV QAYPAIQSYEASFNKNAFTAVLLGRLIPVIPSLVMNVICGLSQVRWHVFFFASLIGKI PNIVVVTIAGANFTSNKLLSISIYGTYILIIMLVIYKKFPHLLKVPKK*" /label="yqeD CDS" gene 2319257..2319883 /gene="yqeD" /locus_tag="BSU_25720" /old_locus_tag="BSU25720" /label="yqeD gene" downshifts 2319851 /Source="Nicolas_upshifts" /id="D1332" /incds=0 /nref=2 /ntot=63 /MaxReadThrough="2.9326" /MaxDrop="2.91074" /score="15.7108141" /energy="-10.3" /TU="U2004" /idTUdmin="U2004" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(2319902..2320795) /gene="yqeC" /locus_tag="BSU_25730" /old_locus_tag="BSU25730" /EC_number="1.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10658669, 15231785; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative catabolic 6-phospho-gluconate dehydrogenase (NAD[+]-dependent)" /protein_id="NP_390450.1" /db_xref="EnsemblGenomes-Gn:BSU25730" /db_xref="EnsemblGenomes-Tr:CAB14514" /db_xref="GOA:P54448" /db_xref="InterPro:IPR004849" /db_xref="InterPro:IPR006114" /db_xref="InterPro:IPR006115" /db_xref="InterPro:IPR006183" /db_xref="InterPro:IPR006184" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11631" /db_xref="UniProtKB/Swiss-Prot:P54448" /translation="MKIGLIGLGKMGINIGKQFIDRNHQVVGYDVNQAAVDELKAYGA EGTTNLKEFISLLHPPRILWVMVPHGIVDAVLRDVSPLLSKGDMIIEAGNSHYKESIR RYNQMKEAGIHYLDAGTSGGMEGARHGACFMVGGDHEAWEIVEPLFRDTAVENGYLYA GEAGSGHFLKMIHNGIEYGMMAAIGEGFEVLENSQFDFDYEKVARVWNHGSVIRSWLM GLTERAFAKDAKLDQIKGIMHSSGEGKWTVETALDLQTATPVIAMSLMMRYRSLTDDT FTGKVVAALRNEFGGHATEKK*" /label="yqeC CDS" gene complement(2319902..2320795) /gene="yqeC" /locus_tag="BSU_25730" /old_locus_tag="BSU25730" /label="yqeC gene" downshifts complement(2319927) /Source="Nicolas_upshifts" /id="D1333" /incds=0 /nref=4 /ntot=12 /MaxReadThrough="1.46947" /MaxDrop="3.03963" /score="0.698755756" /energy="-8.4" /TU="NA" /idTUdmin="U2003" /TUdmin="-1606" /isTUend="FALSE" /label="downshifts" promotor_-35 2320978..2320984 /Source="Nicolas_upshift_promotors" /id="U2005" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.874125874125874" /psig="0.998001998001998" /xcortree=3104 /SigmaFactorBS="tctattactgaatctctttatatccataattatcgctttatc CTTGATTtaccatcagttTAAGTTAAAATATGGGAAGGaattcgattttttcagtaaa a" /listShort="yqeB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2320996..2321015 /Source="Nicolas_upshift_promotors" /id="U2005" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.874125874125874" /psig="0.998001998001998" /xcortree=3104 /SigmaFactorBS="tctattactgaatctctttatatccataattatcgctttatc CTTGATTtaccatcagttTAAGTTAAAATATGGGAAGGaattcgattttttcagtaaa a" /listShort="yqeB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2320996 /Source="Nicolas_upshifts" /id="U2005" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.874125874125874" /psig="0.998001998001998" /xcortree=3104 /SigmaFactorBS="tctattactgaatctctttatatccataattatcgctttatc CTTGATTtaccatcagttTAAGTTAAAATATGGGAAGGaattcgattttttcagtaaa a" /listShort="yqeB" /GFF_Attribute="listLong" /label="upshifts" CDS 2321047..2321769 /gene="yqeB" /locus_tag="BSU_25740" /old_locus_tag="BSU25740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390451.2" /db_xref="EnsemblGenomes-Gn:BSU25740" /db_xref="EnsemblGenomes-Tr:CAB14515" /db_xref="GOA:P54447" /db_xref="SubtiList:BG11630" /db_xref="UniProtKB/Swiss-Prot:P54447" /translation="MLQNQSHTLIGVTKTAVFFLYAALAIIGFAIGYFIPQIAKWALS LPWIPLEGPLRLITSFQGSTASFITALLGMCAGIWFAHSVIAMLLSVKITDHTVEFIK GKKVQTIHSDDIALVFMDHKRLVLLGTAGYELVREEIDEKPVNVEKAFRQHHYEWATD GDPFKDQFRRWIPDAPDLSQGAHALLKARHKALQDEEKDDIEEFRLELAQLGIVVRDE GTRQYWRKAETYPPKIQLGEGL*" /label="yqeB CDS" gene 2321047..2321769 /gene="yqeB" /locus_tag="BSU_25740" /old_locus_tag="BSU25740" /label="yqeB gene" CDS complement(2321802..2322212) /gene="nucB" /locus_tag="BSU_25750" /old_locus_tag="BSU25750" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7746143, 17209033, 21179489" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7746143, 17209033, 21179489; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sporulation-specific matrix degrading exported DNase" /protein_id="NP_390452.1" /db_xref="EnsemblGenomes-Gn:BSU25750" /db_xref="EnsemblGenomes-Tr:CAB14516" /db_xref="GOA:P42983" /db_xref="InterPro:IPR029476" /db_xref="SubtiList:BG11237" /db_xref="UniProtKB/Swiss-Prot:P42983" /translation="MKKWMAGLFLAAAVLLCLMVPQQIQGASSYDKVLYFPLSRYPET GSHIRDAIAEGHPDICTIDRDGADKRREESLKGIPTKPGYDRDEWPMAVCEEGGAGAD VRYVTPSDNRGAGSWVGNQMSSYPDGTRVLFIVQ*" /label="nucB CDS" gene complement(2321802..2322212) /gene="nucB" /locus_tag="BSU_25750" /old_locus_tag="BSU25750" /label="nucB gene" downshifts complement(2321827) /Source="Nicolas_upshifts" /id="D1334" /incds=0 /nref=2 /ntot=20 /MaxReadThrough="0.80212" /MaxDrop="3.40706" /score="-0.144589925" /energy="-9.3" /TU="NA" /idTUdmin="U2006" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2322232..2322250) /Source="Nicolas_upshift_promotors" /id="U2006" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1115 /SigmaFactorBS="cagcatactaacttcaaatgttaAAAATAttcttcatcaagc gcCCATACATTGAAATGAACAaaggtatggggggatggggatgaaaaaatggatggca g" /listShort="nucB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2322234) /Source="Nicolas_upshifts" /id="U2006" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1115 /SigmaFactorBS="cagcatactaacttcaaatgttaAAAATAttcttcatcaagc gcCCATACATTGAAATGAACAaaggtatggggggatggggatgaaaaaatggatggca g" /listShort="nucB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2322266..2322271) /Source="Nicolas_upshift_promotors" /id="U2006" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1115 /SigmaFactorBS="cagcatactaacttcaaatgttaAAAATAttcttcatcaagc gcCCATACATTGAAATGAACAaaggtatggggggatggggatgaaaaaatggatggca g" /listShort="nucB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2322335..2322343 /Source="Nicolas_upshift_promotors" /id="U2007" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp="0.595404595404595" /psig="0.595404595404595" /xcortree=1062 /SigmaFactorBS="ttaccaaagccggactcccccgcgagaaatttcccggtaCAG ACACAGacagcctcccggtCACATACATTTACATATAGGcttttgcctacatactttt g" /listShort="spoIVCB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2322356 /Source="Nicolas_upshifts" /id="U2007" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp="0.595404595404595" /psig="0.595404595404595" /xcortree=1062 /SigmaFactorBS="ttaccaaagccggactcccccgcgagaaatttcccggtaCAG ACACAGacagcctcccggtCACATACATTTACATATAGGcttttgcctacatactttt g" /listShort="spoIVCB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2322357..2322376 /Source="Nicolas_upshift_promotors" /id="U2007" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp="0.595404595404595" /psig="0.595404595404595" /xcortree=1062 /SigmaFactorBS="ttaccaaagccggactcccccgcgagaaatttcccggtaCAG ACACAGacagcctcccggtCACATACATTTACATATAGGcttttgcctacatactttt g" /listShort="spoIVCB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2322408..2322878 /gene="sigKn" /locus_tag="BSU_25760" /old_locus_tag="BSU25760" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8464402, 7704261, 2536191, 2163341, 10974124, 15187183, 20889742" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8464402, 7704261, 2536191, 2163341, 10974124, 15187183, 20889742; Product type r: regulator" /pseudo /codon_start=1 /transl_table=11 /product="RNA polymerase sporulation-specific sigma-K factor precursor (Sigma-27) (N-terminal half)" /db_xref="GOA:P12254" /db_xref="InterPro:IPR000943" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR007630" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="PSEUDO:CAB14517.2" /db_xref="SubtiList:BG10459" /db_xref="UniProtKB/Swiss-Prot:P12254" /translation="MVTGVFAALGFVVKELVFLVSYVKNNAFPQPLSSSEEKKYLELM AKGDEHARNMLIEHNLRLVAHIVKKFENTGEDAEDLISIGTIGLIKGIESYSAGKGTK LATYAARCIENEIVITKGGCIHPSLIRFNIYGVRIHNGNFFHDKVNNCFFIFKS*" /label="sigKn CDS" gene 2322408..2322878 /gene="sigKn" /locus_tag="BSU_25760" /old_locus_tag="BSU25760" /pseudo /label="sigKn gene" downshifts 2322598 /Source="Nicolas_upshifts" /id="D1335" /incds=1 /nref=2 /ntot=5 /MaxReadThrough="7.53734" /MaxDrop="3.01863" /score="-7.46047649" /energy="-12.1" /TU="U2007" /idTUdmin="U2007" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" downshifts 2322730 /Source="Nicolas_upshifts" /id="D1336" /incds=1 /nref=44 /ntot=61 /MaxReadThrough="0.8049" /MaxDrop="7.21386" /score="-7.46047649" /energy="-12.1" /TU="NA" /idTUdmin="U2007" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2322786..2324288) /gene="spoIVCA" /locus_tag="BSU_25770" /old_locus_tag="BSU25770" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1631085, 2163341, 7704261, 8300549, 8969508, 8655528, 18673456" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1631085, 2163341, 7704261, 8300549, 8969508, 8655528, 18673456; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="site-specific DNA recombinase; skin element" /protein_id="NP_390454.2" /db_xref="EnsemblGenomes-Gn:BSU25770" /db_xref="EnsemblGenomes-Tr:CAB14518" /db_xref="GOA:P17867" /db_xref="InterPro:IPR006118" /db_xref="InterPro:IPR006119" /db_xref="InterPro:IPR011109" /db_xref="InterPro:IPR025827" /db_xref="InterPro:IPR036162" /db_xref="SubtiList:BG10458" /db_xref="UniProtKB/Swiss-Prot:P17867" /translation="MIAIYVRVSTEEQAIKGSSIDSQIEACIKKAGTKDVLKYADEGF SGELLERPALNRLREDASKGLISQVICYDPDRLSRKLMNQLIIDDELRKRNIPLIFVN GEYANSPEGQLFFAMRGAISEFEKAKIKERTSSGRLQKMKKGMIIKDSKLYGYKFVKE KRTLEILEEEAKIIRMIFNYFTDHKSPFFGRVNGIALHLTQMGVKTKKGAKVWHRQVV RQILMNSSYKGEHRQYKYDTEGSYVSKQAGNKSIIKIRPEEEQITVTIPAIVPAEQWD YAQELLGQSKRKHLSISPHNYLLSGLVRCGKCGNTMTGKKRKSHGKDYYVYTCRKNYS GAKDRGCGKEMSENKLNRHVWGEIFKFITNPQKYVSFKEAEQSNHLSDELELIEKEIE KTKKGRKRLLTLISLSDDDDLDIDEIKAQIIELQKKQNQLTEKCNEIQSKMKVLDDTS SSENALKRAIDYFQSIGADNLTLEDKKTIVNFIVKEVTIVDSDTIYIETY*" /label="spoIVCA CDS" gene complement(2322786..2324288) /gene="spoIVCA" /locus_tag="BSU_25770" /old_locus_tag="BSU25770" /label="spoIVCA gene" downshifts complement(2322802) /Source="Nicolas_upshifts" /id="D1337" /incds=1 /nref=21 /ntot=131 /MaxReadThrough="2.50085" /MaxDrop="6.35891" /score="-0.144589925" /energy="-9.3" /TU="NA" /idTUdmin="U2008" /TUdmin=4 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2324395..2324413) /Source="Nicolas_upshift_promotors" /id="U2008" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1098 /SigmaFactorBS="gaaacgtttaataacactatagtttaatttaaaatctcCTCA TTtggacaaacagctgttACATAGCATTACCCAAGGGgtgatgcattttatgaaagtg a" /listShort="spoIVCA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2324413) /Source="Nicolas_upshifts" /id="U2008" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1098 /SigmaFactorBS="gaaacgtttaataacactatagtttaatttaaaatctcCTCA TTtggacaaacagctgttACATAGCATTACCCAAGGGgtgatgcattttatgaaagtg a" /listShort="spoIVCA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2324415..2324716) /Source="Nicolas_S_feature" /locus_tag="new_2655000_2655301_c" /HighExp="dia5, Diami, S8, S7, dia15, C30, G135, S6, G180, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.974" /TUlongSig="NA" /TUlongPSig="NA" /label="S972" promotor_-35 complement(2324430..2324435) /Source="Nicolas_upshift_promotors" /id="U2008" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1098 /SigmaFactorBS="gaaacgtttaataacactatagtttaatttaaaatctcCTCA TTtggacaaacagctgttACATAGCATTACCCAAGGGgtgatgcattttatgaaagtg a" /listShort="spoIVCA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2324737..2325156) /gene="arsC" /locus_tag="BSU_25780" /old_locus_tag="BSU25780" /EC_number="1.20.4.4" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11698660, 16192272, 16905151, 8760915, 8969508, 9537360, 17303556, 21258851, 21904062, 23813734" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11698660, 16192272, 16905151, 8760915, 8969508, 9537360, 17303556, 21258851, 21904062, 23813734; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thioredoxin-coupled arsenate reductase; skin element" /protein_id="NP_390455.1" /db_xref="EnsemblGenomes-Gn:BSU25780" /db_xref="EnsemblGenomes-Tr:CAB14519" /db_xref="GOA:P45947" /db_xref="InterPro:IPR014064" /db_xref="InterPro:IPR023485" /db_xref="InterPro:IPR036196" /db_xref="PDB:1JL3" /db_xref="PDB:1Z2D" /db_xref="PDB:1Z2E" /db_xref="PDB:2IPA" /db_xref="SubtiList:BG11304" /db_xref="UniProtKB/Swiss-Prot:P45947" /translation="MENKIIYFLCTGNSCRSQMAEGWAKQYLGDEWKVYSAGIEAHGL NPNAVKAMKEVGIDISNQTSDIIDSDILNNADLVVTLCGDAADKCPMTPPHVKREHWG FDDPARAQGTEEEKWAFFQRVRDEIGNRLKEFAETGK*" /label="arsC CDS" gene complement(2324737..2325156) /gene="arsC" /locus_tag="BSU_25780" /old_locus_tag="BSU25780" /label="arsC gene" downshifts complement(2324761) /Source="Nicolas_upshifts" /id="D1338" /incds=0 /nref=106 /ntot=239 /MaxReadThrough="3.85143" /MaxDrop="6.98965" /score="17.1730317" /energy="-8.6" /TU="U2009" /idTUdmin="U2009" /TUdmin="-1823" /isTUend="FALSE" /label="downshifts" CDS complement(2325168..>2325296) /gene="arsB" /locus_tag="Delta6_pseudo_BSU_25790" /old_locus_tag="BSU25790" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9537360, 15849754, 16850406, 16905151; Product type t: transporter" /codon_start=1 /transl_table=11 /product="arsenite efflux transporter; skin element" /protein_id="NP_390456.2" /db_xref="EnsemblGenomes-Gn:BSU25790" /db_xref="EnsemblGenomes-Tr:CAB14520" /db_xref="GOA:P45946" /db_xref="InterPro:IPR002657" /db_xref="InterPro:IPR004706" /db_xref="SubtiList:BG11303" /db_xref="UniProtKB/Swiss-Prot:P45946" /NCBI_locus_tag="A8O17_RS20905" /modified_by="User" /translation="YRIHSGAAFAAVIGPLVEVPVMIALVKVALWFQRKYFGSHSM*" /label="Delta6_pseudo_BSU_25790" gene complement(2325168..>2325296) /gene="arsB" /locus_tag="Delta6_pseudo_BSU_25790" /old_locus_tag="BSU25790" /NCBI_locus_tag="A8O17_RS20905" /modified_by="User" /label="Delta6_pseudo_BSU_25790" SCAR join(2325292,2325299) /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="TFC7A" N_region 2325293..2325298 /note="EcoRV side (GATATC)" /created_by="User" /modified_by="User" /label="TFC7A" CDS <2325294..2325680 /NCBI_locus_tag="A8O17_RS12485" /NCBI_old_locus_tag="A8O17_12485" /inference="COORDINATES: similar to AA sequence:RefSeq:NP_390515.1" /note="incomplete; partial in the middle of a contig; missing N-terminus; Derived by automated computational analysis using gene prediction method: Protein Homology." /pseudo /codon_start=1 /transl_table=11 /product="ImmA/IrrE family metallo-endopeptidase" /locus_tag="Delta6_pseudo_BSU_26380" /modified_by="User" /translation="ISSFALKHSGIYNICLDSRKSRTEQWYDFAHEFCHIYRHEGDKK TMPATWTDYLDWQSNYFTYHFCIPTCMLRNINLPYIQSHAIENVAWLFKVSPSFAKKR LSIYYRKLTQHLFSQTVTGNLCPPFL*" /label="Delta6_pseudo_BSU_26380" gene <2325294..2325680 /NCBI_locus_tag="A8O17_RS12485" /NCBI_old_locus_tag="A8O17_12485" /pseudo /locus_tag="Delta6_pseudo_BSU_26380" /modified_by="User" /label="Delta6_pseudo_BSU_26380" misc_feature complement(2325647..2325665) /Source="Nicolas_upshift_promotors" /id="U2034" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.888111888111888" /psig="0.888111888111888" /xcortree=1184 /SigmaFactorBS="acgtctttttttgtttttttcaatgcgcgcaaatgcatgagg atttcattattcattacaaaaaggggggGCATAAATTTCCCGTAACAgtttgactaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 2325662..2326078 /gene="sigKc" /locus_tag="BSU_26390" /old_locus_tag="BSU26390" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:2163341, 7704261, 8969508" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2163341, 7704261, 8969508; Product type f: factor" /pseudo /codon_start=1 /transl_table=11 /product="RNA polymerase sporulation-specific sigma-K factor precursor (Sigma-27) (C-terminal fragment)" /db_xref="GOA:P12254" /db_xref="InterPro:IPR000943" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR007630" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="PSEUDO:CAB14580.1" /db_xref="SubtiList:BG10919" /db_xref="UniProtKB/Swiss-Prot:P12254" /translation="MPPLFVMNNEILMHLRALKKTKKDVSLHDPIGQDKEGNEISLID VLKSENEDVIDTIQLNMELEKVKQYIDILDDREKEVIVGRFGLDLKKEKTQREIAKEL GISRSYVSRIEKRALMKMFHEFYRAEKEKRKKAKGK*" /label="sigKc CDS" gene 2325662..2326078 /gene="sigKc" /locus_tag="BSU_26390" /old_locus_tag="BSU26390" /pseudo /label="sigKc gene" misc_feature 2325667..2325681 /Source="Nicolas_upshift_promotors" /id="U2035" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.647352647352647" /psig="0.217782217782218" /xcortree=1060 /SigmaFactorBS="tcaacatttatttagtcaaactgttacgggaaatttatgccC CCCCTTTTTGTAATgaataatgaaatcctcatgcatttgcgcgcattgaaaaaaacaa a" /listShort="spoIIIC, S984" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2325675) /Source="Nicolas_upshifts" /id="U2034" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.888111888111888" /psig="0.888111888111888" /xcortree=1184 /SigmaFactorBS="acgtctttttttgtttttttcaatgcgcgcaaatgcatgagg atttcattattcattacaaaaaggggggGCATAAATTTCCCGTAACAgtttgactaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts 2325686 /Source="Nicolas_upshifts" /id="U2035" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.647352647352647" /psig="0.217782217782218" /xcortree=1060 /SigmaFactorBS="tcaacatttatttagtcaaactgttacgggaaatttatgccC CCCCTTTTTGTAATgaataatgaaatcctcatgcatttgcgcgcattgaaaaaaacaa a" /listShort="spoIIIC, S984" /GFF_Attribute="listLong" /label="upshifts" downshifts 2326062 /Source="Nicolas_upshifts" /id="D1357" /incds=0 /nref=50 /ntot=108 /MaxReadThrough="3.60274" /MaxDrop="5.60264" /score="-0.848064104" /energy="-4.5" /TU="U2035" /idTUdmin="U2033" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS 2326078..2326194 /locus_tag="BSU_26399" /old_locus_tag="BSU26399" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513982.1" /translation="MQKKPDLILRLSLFERVMKIIFFIADKLSEKDRQDRNK*" /label="hypothetical protein CDS" gene 2326078..2326194 /locus_tag="BSU_26399" /old_locus_tag="BSU26399" /label="gene" S_feature 2326107..2327441 /Source="Nicolas_S_feature" /locus_tag="new_2701783_2703117" /HighExp="S8, S6, S7, S5, S4, BT, B36, dia15, C30, H2O2" /AntisenseName="psiE" /AntisenseCor="0.376363934894826" /AntisenseRegPval="-9.8000000000000007" /CDS_PredictionProba="0.117191" /TUshortSig="Sig-" /TUshortPSig="0.218" /TUlongSig="NA" /TUlongPSig="NA" /label="S984" downshifts complement(2326225) /Source="Nicolas_upshifts" /id="D1358" /incds=0 /nref=1 /ntot=20 /MaxReadThrough="3.25265" /MaxDrop="3.18978" /score="3.17084908" /energy="-14.7" /TU="NA" /idTUdmin="U2036" /TUdmin=66 /isTUend="FALSE" /label="downshifts" CDS complement(2326303..2326467) /gene="yrkS" /locus_tag="BSU_26400" /old_locus_tag="BSU26400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_390517.1" /db_xref="EnsemblGenomes-Gn:BSU26400" /db_xref="EnsemblGenomes-Tr:CAB14581" /db_xref="SubtiList:BG11785" /db_xref="UniProtKB/Swiss-Prot:P54446" /translation="MKVIIIEGLQTDKCMNDCYHYLIKLYRQEIQGDSNISWNKRSRD RASTARSRPV*" /label="yrkS CDS" gene complement(2326303..2326467) /gene="yrkS" /locus_tag="BSU_26400" /old_locus_tag="BSU26400" /label="yrkS gene" promotor_-10 complement(2326397..2326416) /Source="Nicolas_upshift_promotors" /id="U2036" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.824175824175824" /psig="0.975024975024975" /xcortree=1403 /SigmaFactorBS="aggggtgatgtattttatgaaggtaataatcatcgagggact gcaAACTGACAaatgcatgaacgatTGCTATCATTATTTAATAAAactttataggcag g" /listShort="yrkS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2326423) /Source="Nicolas_upshifts" /id="U2036" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.824175824175824" /psig="0.975024975024975" /xcortree=1403 /SigmaFactorBS="aggggtgatgtattttatgaaggtaataatcatcgagggact gcaAACTGACAaatgcatgaacgatTGCTATCATTATTTAATAAAactttataggcag g" /listShort="yrkS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2326431..2326438) /Source="Nicolas_upshift_promotors" /id="U2036" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.824175824175824" /psig="0.975024975024975" /xcortree=1403 /SigmaFactorBS="aggggtgatgtattttatgaaggtaataatcatcgagggact gcaAACTGACAaatgcatgaacgatTGCTATCATTATTTAATAAAactttataggcag g" /listShort="yrkS" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2326601) /Source="Nicolas_upshifts" /id="D1359" /incds=0 /nref=79 /ntot=219 /MaxReadThrough="1.20909" /MaxDrop="4.40328" /score="39.3560776" /energy="-10.6" /TU="NA" /idTUdmin="U2036" /TUdmin="-310" /isTUend="FALSE" /label="downshifts" CDS complement(2327012..2327428) /gene="psiE" /locus_tag="BSU_26410" /old_locus_tag="BSU26410" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12897016, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="phosphate starvation inducible protein" /protein_id="NP_390518.2" /db_xref="EnsemblGenomes-Gn:BSU26410" /db_xref="EnsemblGenomes-Tr:CAB14582" /db_xref="GOA:P54445" /db_xref="InterPro:IPR009315" /db_xref="InterPro:IPR020948" /db_xref="SubtiList:BG11784" /db_xref="UniProtKB/Swiss-Prot:P54445" /translation="MRFSNKFKKVPYLLQALLNVCLFFLALALSALLISETWYIVLFV YKSLFNKVDSYYEMLGELLIFFMYFEFIALIIKYFKSDFHFPLRYFIYIGITAVIRLI IIDHDQAISTFWWAMAILAMICGFFIANRRNSVVEH*" /label="psiE CDS" gene complement(2327012..2327428) /gene="psiE" /locus_tag="BSU_26410" /old_locus_tag="BSU26410" /label="psiE gene" CDS complement(2327474..2328772) /gene="yrkQ" /locus_tag="BSU_26420" /old_locus_tag="BSU26420" /EC_number="2.7.13.3" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YrkP]" /protein_id="NP_390519.1" /db_xref="EnsemblGenomes-Gn:BSU26420" /db_xref="EnsemblGenomes-Tr:CAB14583" /db_xref="GOA:P54444" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11783" /db_xref="UniProtKB/Swiss-Prot:P54444" /translation="MAHLKFTLTKKLALLIMVAAIVSGVIFLTLQKITDDLIEGYLSS EEYYHEESARYIQKFSKYVSENELSTSDRKAFGEWVKKENYINLTIFKDQELQYDSIY SESDYGKEKLTQYAQNHSHPVKFSDGEGRVIIDGFYSSRYYDLAFALDLLGATLIFLI IVLFGIRQSLRYLKTIHQEIHILEGGELDYEMTIKGHDELAMIAKSIEDLRKAFLDKL KAIEELQAESRSLVTEMSHDMRTPLTSLIMNLEFAKKEGGEAGASKDRYVANAYGKAL QLKSLSDNLFAYFLLNKEYEADLETVAVKEVIYDLISDQIAILHQEHFRVHISGELPE TYINVNLEELGRVFDNVMSNLLKYADPEEKISITFVSDQEIFEIHVSNTIKLADITPE SNGLGERSIARMMSRMQGQFHSIQKNSKYYIVLRFWNTKM*" /label="yrkQ CDS" gene complement(2327474..2328772) /gene="yrkQ" /locus_tag="BSU_26420" /old_locus_tag="BSU26420" /label="yrkQ gene" CDS complement(2328759..2329454) /gene="yrkP" /locus_tag="BSU_26430" /old_locus_tag="BSU26430" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 18175906" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 18175906; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YrkQ]" /protein_id="NP_390520.1" /db_xref="EnsemblGenomes-Gn:BSU26430" /db_xref="EnsemblGenomes-Tr:CAB14584" /db_xref="GOA:P54443" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11782" /db_xref="UniProtKB/Swiss-Prot:P54443" /translation="MAYRILVVEDDEDIGDLLEESLTRAGYEVLRAKDGKRALQLVND SLDLVILDIMMPGISGIETCQHIRKSSNVPILFLTARSSTLDKTEGLLAGGDDYMTKP FSEEELHARVIAQLRRYTIYQEKKEQEETFLIGGKLRVSEEFNEVWKEEKQIKLSDLE YRILKLLMNKRNKIFSAQNIYESVWGQPYFYCSNNTVMVHIRKLRSKIEDDPARPVYI KTEWGRGYRFGAS*" /label="yrkP CDS" gene complement(2328759..2329454) /gene="yrkP" /locus_tag="BSU_26430" /old_locus_tag="BSU26430" /label="yrkP gene" misc_feature complement(2329520..2329537) /Source="Nicolas_upshift_promotors" /id="U2037" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.270729270729271" /psig="0.737262737262737" /xcortree=673 /SigmaFactorBS="acaaatttgtggcgagcatcagctttcataaattgttaagat ttacgtagtaTCTTATAACGTACTTATTactatgaacgatatatagtaaggacacacg a" /listShort="yrkP" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2329529) /Source="Nicolas_upshifts" /id="U2037" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.270729270729271" /psig="0.737262737262737" /xcortree=673 /SigmaFactorBS="acaaatttgtggcgagcatcagctttcataaattgttaagat ttacgtagtaTCTTATAACGTACTTATTactatgaacgatatatagtaaggacacacg a" /listShort="yrkP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2329615..2329621 /Source="Nicolas_upshift_promotors" /id="U2038" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.76023976023976" /psig="0.145854145854146" /xcortree=1734 /SigmaFactorBS="aatttgtcacattttctaaaaaaaatgatgacTCTTCATaaa ttgTTAAGATTCGGTCTTTATAtttatccattgtaaggctcaagtttttcagatccgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2329628..2329646 /Source="Nicolas_upshift_promotors" /id="U2038" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.76023976023976" /psig="0.145854145854146" /xcortree=1734 /SigmaFactorBS="aatttgtcacattttctaaaaaaaatgatgacTCTTCATaaa ttgTTAAGATTCGGTCTTTATAtttatccattgtaaggctcaagtttttcagatccgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2329643 /Source="Nicolas_upshifts" /id="U2038" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.76023976023976" /psig="0.145854145854146" /xcortree=1734 /SigmaFactorBS="aatttgtcacattttctaaaaaaaatgatgacTCTTCATaaa ttgTTAAGATTCGGTCTTTATAtttatccattgtaaggctcaagtttttcagatccgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 2329722..2330939 /gene="yrkO" /locus_tag="BSU_26440" /old_locus_tag="BSU26440" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 21737930; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390521.1" /db_xref="EnsemblGenomes-Gn:BSU26440" /db_xref="EnsemblGenomes-Tr:CAB14585" /db_xref="GOA:P54442" /db_xref="InterPro:IPR007349" /db_xref="SubtiList:BG11781" /db_xref="UniProtKB/Swiss-Prot:P54442" /translation="MIVQKEGRGQPVSLRERVHFLDIVRGFALLGIIIVNYFLIVDSV KGFEMASDDVLHKLVSWFAEGKFVTLFSFLFGVGFMIFMDRAAQKVESPNKLFARRLS ILLGFGILHITFVWVGDILAFYAVSGFLLLAFYKRTAKTVLRWIIALIVFQFLTPVFT MLYNVINTAGSKNPNFSEFTLFSHSSLTYMESISTRWTDMVTMAAGSFSMIYSMFLMF LLGVYFVKMEFFKDMEAKKPIWKRIWIISTIAFLITQSSILLDMFNLSENMLWKDISS VLGQNGGLTGSMFYMSTFAMLFLYLPQLRGPMMIFTKVGRMSLTCYLLHSIIGTVLFL RYGFGLADHIQSAGTFMFSLAVYFVLMSFSTLWLKRFRYGPMELVWRKLTYGKVNGSP KATPLHSEKSIQK*" /label="yrkO CDS" gene 2329722..2330939 /gene="yrkO" /locus_tag="BSU_26440" /old_locus_tag="BSU26440" /label="yrkO gene" promotor_-35 2330181..2330188 /Source="Nicolas_upshift_promotors" /id="U2039" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.844155844155844" /psig="0.999000999001" /xcortree=1907 /SigmaFactorBS="tatcgcacttatcgtgtttcaaTTCCTGACtcctgttttcac aaTGTTGTACAATGTCATCAATactgcagggtcaaaaaacccgaatttttcagagttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2330203..2330222 /Source="Nicolas_upshift_promotors" /id="U2039" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.844155844155844" /psig="0.999000999001" /xcortree=1907 /SigmaFactorBS="tatcgcacttatcgtgtttcaaTTCCTGACtcctgttttcac aaTGTTGTACAATGTCATCAATactgcagggtcaaaaaacccgaatttttcagagttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2330219 /Source="Nicolas_upshifts" /id="U2039" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.844155844155844" /psig="0.999000999001" /xcortree=1907 /SigmaFactorBS="tatcgcacttatcgtgtttcaaTTCCTGACtcctgttttcac aaTGTTGTACAATGTCATCAATactgcagggtcaaaaaacccgaatttttcagagttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 2330858..2331106 /locus_tag="BSU_26449" /old_locus_tag="BSU26449" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513983.1" /translation="MAQADVRQSKRESQSNSAAFGKIYSEITPLHRLHDFKLVLLNEA GIKRTDLIYGLVIFISFRLLWANKSTRVYSMCIAHDRI*" /label="hypothetical protein CDS" gene 2330858..2331106 /locus_tag="BSU_26449" /old_locus_tag="BSU26449" /label="gene" S_feature complement(2331035..2332082) /Source="Nicolas_S_feature" /locus_tag="new_2706711_2707758_c" /HighExp="Diami, C30, dia15, dia5, Lbstat, S8, C90, G180, H2O2, G135" /AntisenseName="yrkN" /AntisenseCor="0.40539464433869998" /AntisenseRegPval="-11.3" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="1, 0.962, 1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S985" CDS 2331451..2332008 /gene="yrkN" /locus_tag="BSU_26450" /old_locus_tag="BSU26450" /EC_number="2.3.-.-" /function="16.8: Protect" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 18175906; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_390522.1" /db_xref="EnsemblGenomes-Gn:BSU26450" /db_xref="EnsemblGenomes-Tr:CAB14586" /db_xref="GOA:P54441" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11780" /db_xref="UniProtKB/Swiss-Prot:P54441" /translation="MKTKNEPKVILELAKESDLPEFQKKLQEAFAIAVIETFGDCEDG PIPSDNDVQESFNAPGAVVYHILQDGKNVGGAVVRINSQTNHNSLDLFYVSPEYHSQG IGLSAWKAIEAQYPDTVLWETVTPYFEKRNINFYVNKCGFHIVEFYNEHHSNPHMHRN GREDDKPLLNDDDFFRFVKIMKKKD*" /label="yrkN CDS" gene 2331451..2332008 /gene="yrkN" /locus_tag="BSU_26450" /old_locus_tag="BSU26450" /label="yrkN gene" S_feature 2332009..2332131 /Source="Nicolas_S_feature" /locus_tag="new_2707685_2707807" /HighExp="S8, Sw, C30, S7, BC, C90, Lbstat, Mal, LoTm, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S986" S_feature complement(2332084..2332498) /Source="Nicolas_S_feature" /locus_tag="new_2707760_2708174_c" /HighExp="M0t90, M40t90, Lbstat, dia5, LPhT, dia15, M9-stat, Lbtran, C90, Etha" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="1, 0.962, 1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S987" downshifts complement(2332127) /Source="Nicolas_upshifts" /id="D1360" /incds=0 /nref=81 /ntot=255 /MaxReadThrough="5.45539" /MaxDrop="5.6563" /score="-3.35079978" /energy="-23.7" /TU="U2041,U2042,U2044,U2045" /idTUdmin="U2042" /TUdmin="-182" /isTUend="FALSE" /label="downshifts" CDS complement(2332499..2333023) /gene="yrkL" /locus_tag="BSU_26470" /old_locus_tag="BSU26470" /EC_number="1.6.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11053405; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD(P)H oxidoreductase" /protein_id="NP_390524.2" /db_xref="EnsemblGenomes-Gn:BSU26470" /db_xref="EnsemblGenomes-Tr:CAB14588" /db_xref="GOA:P54439" /db_xref="InterPro:IPR003680" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG11778" /db_xref="UniProtKB/Swiss-Prot:P54439" /translation="MKTLVIVIHPNLETSVVNKTWMNRLKQEKDITVHDLYGEYPNFI IDVEKEQQLLLDHERIVFQFPMYWYSSPALLKQWEDDVLTHGWAYGTGGTKLHGKELL LAISLGAQESDYQAGGEYNITISELIRPFQVTANYIGMRFLPAFTQYGTLHLSKEDVK NSAERLVDYLKAEH*" /label="yrkL CDS" gene complement(2332499..2333023) /gene="yrkL" /locus_tag="BSU_26470" /old_locus_tag="BSU26470" /label="yrkL gene" promotor_-35 2332871..2332878 /Source="Nicolas_upshift_promotors" /id="U2040" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.972027972027972" /psig="0.996003996003996" /xcortree=458 /SigmaFactorBS="cgatacgctcatgatctaacaggagctgCTGCTCTTtttcta catcAATGATAAAATTAGGGTATTcaccgtacaggtcatgaaccgtaatgtctttctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2332889..2332908 /Source="Nicolas_upshift_promotors" /id="U2040" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.972027972027972" /psig="0.996003996003996" /xcortree=458 /SigmaFactorBS="cgatacgctcatgatctaacaggagctgCTGCTCTTtttcta catcAATGATAAAATTAGGGTATTcaccgtacaggtcatgaaccgtaatgtctttctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2332903 /Source="Nicolas_upshifts" /id="U2040" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.972027972027972" /psig="0.996003996003996" /xcortree=458 /SigmaFactorBS="cgatacgctcatgatctaacaggagctgCTGCTCTTtttcta catcAATGATAAAATTAGGGTATTcaccgtacaggtcatgaaccgtaatgtctttctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2333024..2333111) /Source="Nicolas_S_feature" /locus_tag="new_2708700_2708787_c" /HighExp="dia5, Etha, dia15, M9-stat, M0t90, Lbtran, Diami, C90, T3.0H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="1, 0.962, 1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S988" promotor_-10 complement(2333106..2333125) /Source="Nicolas_upshift_promotors" /id="U2041" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2050 /SigmaFactorBS="tcatcattgattttggtgcccaatTAGTTGCCctgaattcat gaaaAAGGATAAAATAGGTGTAAAtaaagttgctattttaaaattagaatcaattcat t" /listShort="S988, yrkL, S987, S985" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2333111) /Source="Nicolas_upshifts" /id="U2041" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2050 /SigmaFactorBS="tcatcattgattttggtgcccaatTAGTTGCCctgaattcat gaaaAAGGATAAAATAGGTGTAAAtaaagttgctattttaaaattagaatcaattcat t" /listShort="S988, yrkL, S987, S985" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2333113..2333266) /Source="Nicolas_S_feature" /locus_tag="new_2708789_2708942_c" /HighExp="M0t90, M9-stat, Lbstat, M40t90, T1.30H, C90, Lbtran, T0.30H, dia15, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.962, 1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S989" promotor_-35 complement(2333140..2333147) /Source="Nicolas_upshift_promotors" /id="U2041" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2050 /SigmaFactorBS="tcatcattgattttggtgcccaatTAGTTGCCctgaattcat gaaaAAGGATAAAATAGGTGTAAAtaaagttgctattttaaaattagaatcaattcat t" /listShort="S988, yrkL, S987, S985" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2333267..2333743) /gene="yrkK" /locus_tag="BSU_26480" /old_locus_tag="BSU26480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390525.2" /db_xref="EnsemblGenomes-Gn:BSU26480" /db_xref="EnsemblGenomes-Tr:CAB14589" /db_xref="GOA:P54438" /db_xref="InterPro:IPR025671" /db_xref="SubtiList:BG11777" /db_xref="UniProtKB/Swiss-Prot:P54438" /translation="MVYFVAFFCFAITLHNIEEAIWLPEWSQQSSKFQKPVTSNEFHF AVIVITMLAYLSAFGFLYMPESDIAKWIFIGFLGSMVINAIFPHLIATVVMKKYAPGL LTGLLLNIPVNSLVIYQMFLKNLIVWKELIISTLVVGIILLALIPLLFKVGDKVSP*" /label="yrkK CDS" gene complement(2333267..2333743) /gene="yrkK" /locus_tag="BSU_26480" /old_locus_tag="BSU26480" /label="yrkK gene" promotor_-10 complement(2333779..2333798) /Source="Nicolas_upshift_promotors" /id="U2042" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.553446553446553" /psig="0.962037962037962" /xcortree=3147 /SigmaFactorBS="caactactaaggcagattcttctctcttttaacaCCATATCC aatcagcctcaaaTGTAATATAATGTTGCCAAAccatattggttgtggcaccgaggag g" /listShort="yrkK, S989, S988, yrkL, S987, S985" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2333793) /Source="Nicolas_upshifts" /id="U2042" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.553446553446553" /psig="0.962037962037962" /xcortree=3147 /SigmaFactorBS="caactactaaggcagattcttctctcttttaacaCCATATCC aatcagcctcaaaTGTAATATAATGTTGCCAAAccatattggttgtggcaccgaggag g" /listShort="yrkK, S989, S988, yrkL, S987, S985" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2333795..2334325) /Source="Nicolas_S_feature" /locus_tag="new_2709471_2710001_c" /HighExp="Diami, dia15, S8, G180, Etha, G135, S6, S0, G150, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S990" promotor_-35 complement(2333812..2333819) /Source="Nicolas_upshift_promotors" /id="U2042" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.553446553446553" /psig="0.962037962037962" /xcortree=3147 /SigmaFactorBS="caactactaaggcagattcttctctcttttaacaCCATATCC aatcagcctcaaaTGTAATATAATGTTGCCAAAccatattggttgtggcaccgaggag g" /listShort="yrkK, S989, S988, yrkL, S987, S985" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2334326..2335111) /gene="yrkJ" /locus_tag="BSU_26490" /old_locus_tag="BSU26490" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_390526.1" /db_xref="EnsemblGenomes-Gn:BSU26490" /db_xref="EnsemblGenomes-Tr:CAB14590" /db_xref="GOA:P54437" /db_xref="InterPro:IPR002781" /db_xref="SubtiList:BG11776" /db_xref="UniProtKB/Swiss-Prot:P54437" /translation="MDIAFITTLFIIGFIGAFISGMIGIGGAVINYPMLLYIPSLVGV MSLTAHEVSGIGAIQVFFATLGGVWAYRKSGLINKTLIIYMGSSILLGSVLGSYFSHY ISEKGINFIYGILAIIAVILMFIPKKGQKGQEHSEDKEVIFNKWLASSLAFIIGGVSG ILGAGGAFILVPIMLSILNIPVRVTVASSLAITFLSSIGATVGKVITGQVLFVPALVL MITSLIASPIGASVGQKVNTKFLQWVLAQLIGATAIKIWLELL*" /label="yrkJ CDS" gene complement(2334326..2335111) /gene="yrkJ" /locus_tag="BSU_26490" /old_locus_tag="BSU26490" /label="yrkJ gene" CDS complement(2335172..2335399) /gene="yrkI" /locus_tag="BSU_26500" /old_locus_tag="BSU26500" /function="5.5: Sulfur metabolism" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9555915; Product type c: carrier" /codon_start=1 /transl_table=11 /product="putative sulfur-carrier protein" /protein_id="NP_390527.1" /db_xref="EnsemblGenomes-Gn:BSU26500" /db_xref="EnsemblGenomes-Tr:CAB14591" /db_xref="GOA:P54436" /db_xref="InterPro:IPR001455" /db_xref="InterPro:IPR036868" /db_xref="SubtiList:BG11775" /db_xref="UniProtKB/Swiss-Prot:P54436" /translation="MKSDKVLDAKGLACPMPIVRTKKAMNELESGQILEVHATDKGAK NDLTAWSKSGGHDLLEQTDEGDILKFWIQKG*" /label="yrkI CDS" gene complement(2335172..2335399) /gene="yrkI" /locus_tag="BSU_26500" /old_locus_tag="BSU26500" /label="yrkI gene" downshifts complement(2335196) /Source="Nicolas_upshifts" /id="D1361" /incds=0 /nref=4 /ntot=22 /MaxReadThrough="5.31659" /MaxDrop="3.95633" /score="-3.35079978" /energy="-23.7" /TU="U2044,U2045" /idTUdmin="U2046" /TUdmin=3085 /isTUend="FALSE" /label="downshifts" CDS complement(2335433..2336566) /gene="yrkH" /locus_tag="BSU_26510" /old_locus_tag="BSU26510" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sulfur transferase / hydrolase" /protein_id="NP_390528.2" /db_xref="EnsemblGenomes-Gn:BSU26510" /db_xref="EnsemblGenomes-Tr:CAB14592" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR001763" /db_xref="InterPro:IPR036866" /db_xref="InterPro:IPR036873" /db_xref="SubtiList:BG11774" /db_xref="UniProtKB/Swiss-Prot:P54435" /translation="MKHDRKGNDPKRSDKKIFNKEPLFILDVRNENDFSDWKIEGHDF DHLNVPYFDLLDGVEDILEKIPSDKEVLVVCAKEGSSVMVSEMLSEAGHSVSYLKGGM KAWSEHLEPVKVGDLKDGGEMYQFVRIGKGCLSYMVISNGEAAIIDATRMVNFFIDFA KGKGATITHVFDTHLHADHISGGRVIAEKTKATYWLPPKDAEEVEFDYQPLEEGNDII IGNTTIKIQPIYSPGHTIGSTSFIVDDQYLLSGDILFIDSIGRPDLAGMAEDWVGDLR KTLYSRYKALSKDLIVLPAHFMIIDELNENGSVGKQLSTLFSENHGLNIADETEFRHL VTDHLPPQPNAYQEIRETNMGKISPDEEKQREMEIGPNRCAIR*" /label="yrkH CDS" gene complement(2335433..2336566) /gene="yrkH" /locus_tag="BSU_26510" /old_locus_tag="BSU26510" /label="yrkH gene" misc_feature complement(2336268..2336283) /Source="Nicolas_upshift_promotors" /id="U2043" /multdbtbs="-" /comp="M19" /sig="Sig-" /pcomp="0.410589410589411" /psig="0.477522477522478" /xcortree=1482 /SigmaFactorBS="aaaagaaggttcatccgtcatggtatccgaaatgctttctga agcaggtcattctgTATCCTACCTTAAGGGtggaatgaaagcatggagcgaacattta g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2336279) /Source="Nicolas_upshifts" /id="U2043" /multdbtbs="-" /comp="M19" /sig="Sig-" /pcomp="0.410589410589411" /psig="0.477522477522478" /xcortree=1482 /SigmaFactorBS="aaaagaaggttcatccgtcatggtatccgaaatgctttctga agcaggtcattctgTATCCTACCTTAAGGGtggaatgaaagcatggagcgaacattta g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2336567..2336900) /Source="Nicolas_S_feature" /locus_tag="new_2712243_2712576_c" /HighExp="Diami, dia15, Sw, BC, S0, G180, dia5, G135, M9-stat, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99950300000000003" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S991" CDS complement(2336901..2337458) /gene="yrkF" /locus_tag="BSU_26530" /old_locus_tag="BSU26530" /function="5.5: Sulfur metabolism" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative rhodanese-related sulfur transferase" /protein_id="NP_390530.1" /db_xref="EnsemblGenomes-Gn:BSU26530" /db_xref="EnsemblGenomes-Tr:CAB14594" /db_xref="InterPro:IPR001455" /db_xref="InterPro:IPR001763" /db_xref="InterPro:IPR036868" /db_xref="InterPro:IPR036873" /db_xref="SubtiList:BG11772" /db_xref="UniProtKB/Swiss-Prot:P54433" /translation="MMKATIVLDAKGLACPMPIVKTKKRMKDLKAGEVLEIHATDKGS TADLEAWAKSTGHEYLGTEAEGEILRHFLRKGGEHSSENASSIPEISLEAFKQKVDSD ESLNILDVREIEEYEKAHIPGVVHIPLGEVEKRANELNENDEIYIICHSGRRSEMAAR TMKKQGFKKVINVVPGMRDWTGKTE*" /label="yrkF CDS" gene complement(2336901..2337458) /gene="yrkF" /locus_tag="BSU_26530" /old_locus_tag="BSU26530" /label="yrkF gene" S_feature complement(2337459..2337643) /Source="Nicolas_S_feature" /locus_tag="new_2713135_2713319_c" /HighExp="Diami, dia15, Sw, BC, S8, dia5, G180, S7, S0, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.12629799999999999" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S992" CDS complement(2337644..2338126) /gene="yrkE" /locus_tag="BSU_26540" /old_locus_tag="BSU26540" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative protein involved in sulfur metabolism (DsrE-like)" /protein_id="NP_390531.1" /db_xref="EnsemblGenomes-Gn:BSU26540" /db_xref="EnsemblGenomes-Tr:CAB14595" /db_xref="InterPro:IPR027396" /db_xref="InterPro:IPR032836" /db_xref="SubtiList:BG11771" /db_xref="UniProtKB/Swiss-Prot:P54432" /translation="MTEQTKRTTIVLFSGDYDKAMAAYIIANGAAAYDHEVTIFHTFW GFNALRKEELIPVKKGFLEKMFGKMMPRGADKMGLSKMNFAGMGPKMIKNVMKKHNVL TLPQLIEMAQEQGVKLVACTMTMDLLGLQEKELLDDIDYAGVAAYLADAEEGSVNLFI *" /label="yrkE CDS" gene complement(2337644..2338126) /gene="yrkE" /locus_tag="BSU_26540" /old_locus_tag="BSU26540" /label="yrkE gene" S_feature complement(2338127..2338235) /Source="Nicolas_S_feature" /locus_tag="new_2713803_2713911_c" /HighExp="Diami, dia15, Sw, BC, dia5, S8, G180, S6, Oxctl, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S993" CDS complement(2338273..2338464) /gene="yrkD" /locus_tag="BSU_26550" /old_locus_tag="BSU26550" /function="5.5: Sulfur metabolism" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 21339296; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative metal-sensitive transcriptional regulator involved in sulfur metabolism" /protein_id="NP_390532.1" /db_xref="EnsemblGenomes-Gn:BSU26550" /db_xref="EnsemblGenomes-Tr:CAB14596" /db_xref="GOA:P54431" /db_xref="InterPro:IPR003735" /db_xref="SubtiList:BG11770" /db_xref="UniProtKB/Swiss-Prot:P54431" /translation="MMEQGKDCREVVTQLAASRNAIDRAMGLIVSTNLEHCVRESLEK GEDTQNLVKEAVDLLVKSR*" /label="yrkD CDS" gene complement(2338273..2338464) /gene="yrkD" /locus_tag="BSU_26550" /old_locus_tag="BSU26550" /label="yrkD gene" downshifts complement(2338280) /Source="Nicolas_upshifts" /id="D1362" /incds=0 /nref=153 /ntot=252 /MaxReadThrough="8.17686" /MaxDrop="5.42995" /score="-6.39526496" /energy="-7.9" /TU="U2044,U2045" /idTUdmin="U2046" /TUdmin=1 /isTUend="TRUE" /label="downshifts" S_feature complement(2338465..2338554) /Source="Nicolas_S_feature" /locus_tag="new_2714141_2714230_c" /HighExp="Diami, dia15, S6, S7, S8, Etha, dia5, S5, BC, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigK" /TUshortPSig="1, 0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S994" CDS complement(2338555..2338872) /gene="yrzM" /locus_tag="BSU_26558" /old_locus_tag="BSU26558" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /db_xref="PSEUDO:CAX52666.1" /translation="MIIIATYRRYYPITGISCIHKDKLEAMDITILDIRHYNDVANFS DNIILNIPYAYLKRFYLEIPRDKIHIIARDRVELNLGVRFLKRKGIHVNSYELATCKC KNK*" /label="yrzM CDS" gene complement(2338555..2338872) /gene="yrzM" /locus_tag="BSU_26558" /old_locus_tag="BSU26558" /pseudo /label="yrzM gene" promotor_-10 complement(2338661..2338680) /Source="Nicolas_upshift_promotors" /id="U2044" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=1899 /SigmaFactorBS="aatattattttaaacatcccatatgcgtatctaaaacgTTTT TATttagagattccaCGTGATAAAATACACATAATagctcgtgaccgggtggaattaa a" /listShort="S994, yrkD, S993, yrkE, S992, yrkF, S991, yrkH, yrkI, yrkJ, S990, yrkK, S989, S988, yrkL, S987, S985" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2338677) /Source="Nicolas_upshifts" /id="U2044" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=1899 /SigmaFactorBS="aatattattttaaacatcccatatgcgtatctaaaacgTTTT TATttagagattccaCGTGATAAAATACACATAATagctcgtgaccgggtggaattaa a" /listShort="S994, yrkD, S993, yrkE, S992, yrkF, S991, yrkH, yrkI, yrkJ, S990, yrkK, S989, S988, yrkL, S987, S985" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2338693..2338699) /Source="Nicolas_upshift_promotors" /id="U2044" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=1899 /SigmaFactorBS="aatattattttaaacatcccatatgcgtatctaaaacgTTTT TATttagagattccaCGTGATAAAATACACATAATagctcgtgaccgggtggaattaa a" /listShort="S994, yrkD, S993, yrkE, S992, yrkF, S991, yrkH, yrkI, yrkJ, S990, yrkK, S989, S988, yrkL, S987, S985" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2338914..2339129) /gene="yrzN" /locus_tag="BSU_26559" /old_locus_tag="BSU26559" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:CAX52667.1" /translation="MINKADLKLNRLIALFEFLLAELALSNVSIFSIRGYRNESISSK KVTFTLDYIPMGVYYCFVNKQRVNKVV*" /label="yrzN CDS" gene complement(2338914..2339129) /gene="yrzN" /locus_tag="BSU_26559" /old_locus_tag="BSU26559" /pseudo /label="yrzN gene" promotor_-10 complement(2338942..2338961) /Source="Nicolas_upshift_promotors" /id="U2045" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.728271728271728" /psig="0.998001998001998" /xcortree=1794 /SigmaFactorBS="tgaatctatcagctcaaagaaagtaactttcacACTTGACTa tatacctatggggGTATATTATTGTTTTGTGAAtaaacaaagagttaataaggtggtg t" /listShort="yrzM, S994, yrkD, S993, yrkE, S992, yrkF, S991, yrkH, yrkI, yrkJ, S990, yrkK, S989, S988, yrkL, S987, S985" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2338956) /Source="Nicolas_upshifts" /id="U2045" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.728271728271728" /psig="0.998001998001998" /xcortree=1794 /SigmaFactorBS="tgaatctatcagctcaaagaaagtaactttcacACTTGACTa tatacctatggggGTATATTATTGTTTTGTGAAtaaacaaagagttaataaggtggtg t" /listShort="yrzM, S994, yrkD, S993, yrkE, S992, yrkF, S991, yrkH, yrkI, yrkJ, S990, yrkK, S989, S988, yrkL, S987, S985" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2338976..2338983) /Source="Nicolas_upshift_promotors" /id="U2045" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.728271728271728" /psig="0.998001998001998" /xcortree=1794 /SigmaFactorBS="tgaatctatcagctcaaagaaagtaactttcacACTTGACTa tatacctatggggGTATATTATTGTTTTGTGAAtaaacaaagagttaataaggtggtg t" /listShort="yrzM, S994, yrkD, S993, yrkE, S992, yrkF, S991, yrkH, yrkI, yrkJ, S990, yrkK, S989, S988, yrkL, S987, S985" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2339130..2339256) /Source="Nicolas_S_feature" /locus_tag="new_2714806_2714932_c" /HighExp="S6, S7, S8, S5, BT, B36, G/S, BC, Pyr, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.114547" /TUshortSig="SigK, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S995" CDS complement(2339257..2339817) /gene="yrkC" /locus_tag="BSU_26560" /old_locus_tag="BSU26560" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10704478; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme; cupin family" /protein_id="NP_390533.1" /db_xref="EnsemblGenomes-Gn:BSU26560" /db_xref="EnsemblGenomes-Tr:CAB14597" /db_xref="GOA:P54430" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR013096" /db_xref="InterPro:IPR014710" /db_xref="SubtiList:BG11769" /db_xref="UniProtKB/Swiss-Prot:P54430" /translation="MYYNPFSPQCYYYVTVPMYNDGRSVYWTIPNEMEKVHRGADLRS SYEDRNLLLKDYGPKPFVVNINRATKQNNTFRTALWTGKHFQVTLMSLGIGEDIGLEI HPNVDQFLRIEQGRGIVKMGKSKDHLNFQRNVYDDSAIVVPAGTWHNVINTGNTPLKL YSIYAPPNHPFGTVHETKADAVAAED*" /label="yrkC CDS" gene complement(2339257..2339817) /gene="yrkC" /locus_tag="BSU_26560" /old_locus_tag="BSU26560" /label="yrkC gene" CDS complement(2339834..2340010) /locus_tag="BSU_26569" /old_locus_tag="BSU26569" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513984.1" /translation="MLTKASEIQHLENDYKVGDKLFIHESNGDRTFIFVFNMSFLDLA HSLNKCIGYYHKNL*" /label="hypothetical protein CDS" gene complement(2339834..2340010) /locus_tag="BSU_26569" /old_locus_tag="BSU26569" /label="gene" promotor_-10 complement(2339844..2339863) /Source="Nicolas_upshift_promotors" /id="U2046" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1282 /SigmaFactorBS="catttttgtgtttaatatgagttttcttgaTTTAGCACACtc ccttaataaaTGCATAGGATACTATCACAAaaatttataattgcggggatcaaaaaat g" /listShort="yrkC, S995, yrzN, yrzM, S994, yrkD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2339855) /Source="Nicolas_upshifts" /id="U2046" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1282 /SigmaFactorBS="catttttgtgtttaatatgagttttcttgaTTTAGCACACtc ccttaataaaTGCATAGGATACTATCACAAaaatttataattgcggggatcaaaaaat g" /listShort="yrkC, S995, yrzN, yrzM, S994, yrkD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2339857..2340042) /Source="Nicolas_S_feature" /locus_tag="new_2715533_2715718_c" /HighExp="BC, Sw, S3, dia15, Etha, S4, S5, H2O2, LBGtran, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.49093999999999999" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S996" promotor_-35 complement(2339876..2339885) /Source="Nicolas_upshift_promotors" /id="U2046" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1282 /SigmaFactorBS="catttttgtgtttaatatgagttttcttgaTTTAGCACACtc ccttaataaaTGCATAGGATACTATCACAAaaatttataattgcggggatcaaaaaat g" /listShort="yrkC, S995, yrzN, yrzM, S994, yrkD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2340043..2340189) /gene="yrkB" /locus_tag="BSU_26570" /old_locus_tag="BSU26570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_390534.1" /db_xref="EnsemblGenomes-Gn:BSU26570" /db_xref="EnsemblGenomes-Tr:CAB14598" /db_xref="SubtiList:BG11768" /db_xref="UniProtKB/Swiss-Prot:P54429" /translation="MLLKNWPSRRIQRDKSKRAGIGGTNNRIPYTLLLCYVNVQKPFR IVDL*" /label="yrkB CDS" gene complement(2340043..2340189) /gene="yrkB" /locus_tag="BSU_26570" /old_locus_tag="BSU26570" /label="yrkB gene" CDS complement(2340359..2341180) /gene="bltR" /locus_tag="BSU_26580" /old_locus_tag="BSU26580" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7608059, 9083003, 10200972, 21954605" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7608059, 9083003, 10200972, 21954605; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (polyamine metabolism)" /protein_id="NP_390535.1" /db_xref="EnsemblGenomes-Gn:BSU26580" /db_xref="EnsemblGenomes-Tr:CAB14599" /db_xref="GOA:P39842" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="InterPro:IPR011256" /db_xref="SubtiList:BG10904" /db_xref="UniProtKB/Swiss-Prot:P39842" /translation="MSEDVKKYFTTGEFSKLCRVKKQTLFHYDEIGLFSPEIKKENGY RYYSYHQFETFQVISLFKELGVPLKEIKCLIKGKTPDKILHVLKEKSIEIDKKINELK QLQTILQTKVTLTEQALETDFSSISFEYLNEETFMLSRKTLNLPERKYVAAISELIHE VQQYELDEGYPIGGIFAREQILEKDFYNYSYFYIKVKDGAENINYHVRPKGLYAVGYE IGGNTEEAYRRIIEFIERNGMQIGENAYEEYMLDEMVVDGYENTYAKILLQVKEV*" /label="bltR CDS" gene complement(2340359..2341180) /gene="bltR" /locus_tag="BSU_26580" /old_locus_tag="BSU26580" /label="bltR gene" promotor_-35 2341188..2341195 /Source="Nicolas_upshift_promotors" /id="U2048" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig="0.997002997002997" /xcortree=1531 /SigmaFactorBS="acttcttaacatcttcgctcataaaaaccTCCTTGACtatac ggtaaccataTACCTTATGATTTGATTGTActtgaaaaaagcttcaagcgaaaaggat a" /listShort="blt" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(2341190..2341209) /Source="Nicolas_upshift_promotors" /id="U2047" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.561438561438561" /psig="0.966033966033966" /xcortree=1901 /SigmaFactorBS="tttttacctatccttttcgcttgaagcttttttcaagtacaa tcaaatcataaggtatATGGTTACCGTATAGTCAAGgaggtttttatgagcgaagatg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2341207) /Source="Nicolas_upshifts" /id="U2047" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.561438561438561" /psig="0.966033966033966" /xcortree=1901 /SigmaFactorBS="tttttacctatccttttcgcttgaagcttttttcaagtacaa tcaaatcataaggtatATGGTTACCGTATAGTCAAGgaggtttttatgagcgaagatg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2341209..2343213) /Source="Nicolas_S_feature" /locus_tag="new_2716885_2718889_c" /HighExp="BC, Sw, Salt, Mal, T4.0H, M9-stat, T3.30H, G180, G135, MG 5" /AntisenseName="blt" /AntisenseCor="0.56943492854420497" /AntisenseRegPval="-23.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S997" promotor_-10 2341211..2341230 /Source="Nicolas_upshift_promotors" /id="U2048" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig="0.997002997002997" /xcortree=1531 /SigmaFactorBS="acttcttaacatcttcgctcataaaaaccTCCTTGACtatac ggtaaccataTACCTTATGATTTGATTGTActtgaaaaaagcttcaagcgaaaaggat a" /listShort="blt" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2341219 /Source="Nicolas_upshifts" /id="U2048" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig="0.997002997002997" /xcortree=1531 /SigmaFactorBS="acttcttaacatcttcgctcataaaaaccTCCTTGACtatac ggtaaccataTACCTTATGATTTGATTGTActtgaaaaaagcttcaagcgaaaaggat a" /listShort="blt" /GFF_Attribute="listLong" /label="upshifts" CDS 2341297..2342499 /gene="blt" /locus_tag="BSU_26590" /old_locus_tag="BSU26590" /function="16.1: Circulate" /function="16.4: Excrete" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9083003, 10200972, 10359661, 12793527, 15849754, 16850406, 19114526, 21954605" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9083003, 10200972, 10359661, 12793527, 15849754, 16850406, 19114526, 21954605; Product type t: transporter" /codon_start=1 /transl_table=11 /product="efflux transporter (promiscuous, acetylated polyamines efflux)" /protein_id="NP_390536.1" /db_xref="EnsemblGenomes-Gn:BSU26590" /db_xref="EnsemblGenomes-Tr:CAB14600" /db_xref="GOA:P39843" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR004734" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10905" /db_xref="UniProtKB/Swiss-Prot:P39843" /translation="MKKSINEQKTIFIILLSNIFVAFLGIGLIIPVMPSFMKIMHLSG STMGYLVAAFAISQLITSPFAGRWVDRFGRKKMIILGLLIFSLSELIFGLGTHVSIFY FSRILGGVSAAFIMPAVTAYVADITTLKERSKAMGYVSAAISTGFIIGPGAGGFIAGF GIRMPFFFASAIALIAAVTSVFILKESLSIEERHQLSSHTKESNFIKDLKRSIHPVYF IAFIIVFVMAFGLSAYETVFSLFSDHKFGFTPKDIAAIITISSIVAVVIQVLLFGKLV NKLGEKRMIQLCLITGAILAFVSTVMSGFLTVLLVTCFIFLAFDLLRPALTAHLSNMA GNQQGFVAGMNSTYTSLGNIFGPALGGILFDLNIHYPFLFAGFVMIVGLGLTMVWKEK KNDAAALN*" /label="blt CDS" gene 2341297..2342499 /gene="blt" /locus_tag="BSU_26590" /old_locus_tag="BSU26590" /label="blt gene" CDS 2342668..2343126 /gene="bltD" /locus_tag="BSU_26600" /old_locus_tag="BSU26600" /EC_number="2.3.1.57" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10200972, 10359661, 12793527, 9083003, 16210326, 21954605, 28197687" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10200972, 10359661, 12793527, 9083003, 16210326, 21954605, 28197687; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spermine/spermidine acetyltransferase" /protein_id="NP_390537.1" /db_xref="EnsemblGenomes-Gn:BSU26600" /db_xref="EnsemblGenomes-Tr:CAB14601" /db_xref="GOA:P39909" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR027455" /db_xref="SubtiList:BG10906" /db_xref="UniProtKB/Swiss-Prot:P39909" /translation="MSINIKAVTDDNRAAILDLHVSQNQLSYIESTKVCLEDAKECHY YKPVGLYYEGDLVGFAMYGLFPEYDEDNKNGRVWLDRFFIDERYQGKGLGKKMLKALI QHLAELYKCKRIYLSIFENNIHAIRLYQRFGFQFNGELDFNGEKVMVKEL*" /label="bltD CDS" gene 2342668..2343126 /gene="bltD" /locus_tag="BSU_26600" /old_locus_tag="BSU26600" /label="bltD gene" downshifts complement(2343258) /Source="Nicolas_upshifts" /id="D1363" /incds=0 /nref=77 /ntot=211 /MaxReadThrough="5.09534" /MaxDrop="4.8114" /score="-0.00168005652" /energy="-10.7" /TU="U2049" /idTUdmin="U2051" /TUdmin=3845 /isTUend="FALSE" /label="downshifts" CDS complement(2343283..2344587) /gene="yrkA" /locus_tag="BSU_26610" /old_locus_tag="BSU26610" /function="16.8: Protect" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative membrane associated protein" /protein_id="NP_390538.1" /db_xref="EnsemblGenomes-Gn:BSU26610" /db_xref="EnsemblGenomes-Tr:CAB14602" /db_xref="GOA:P54428" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR002550" /db_xref="InterPro:IPR005170" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG11767" /db_xref="UniProtKB/Swiss-Prot:P54428" /translation="MTTINLIIFTLLIVLTAFFVATEFAIVKIRSSKIDQLILEGKKG AISAKKVITHLDEYLSACQLGITVTALGIGWVGESTFEVILHPLFAHFHVSETVSHVL ILVIAFVMATFLHVVVGELAPKTLAIQKAETITLLTAKPIIWFYRILFPFIWFLNGSA RFIVGLFGLKPASEHELAHSEEELRILLSESYKSGEINQNELKYVNNIFEFDERIAKE IMIPRREIVAISSEDSYETIVKIIKTESYTRYPVLNGDKDSIIGFINAKEFLSAYIDT DQKIKEDFKLENHINPVIHVIESVPIHDVLVKMQKERTHIAILVDEYGGTSGLVTAED ILEEIVGEIRDEFDKDEVPNIRKVNDNHYILDSKVLIEDVNDLLGTTLASDEVDTIGG WFMTQQIDAAVGSVIEADGYIFKVHETVGRHINYLEIVRKKE*" /label="yrkA CDS" gene complement(2343283..2344587) /gene="yrkA" /locus_tag="BSU_26610" /old_locus_tag="BSU26610" /label="yrkA gene" S_feature complement(2344588..2344667) /Source="Nicolas_S_feature" /locus_tag="new_2720264_2720343_c" /HighExp="BC, Sw, MG 15, Mal, Salt, MG 25, MG-0.2, MG 45, MG 5, M/G" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S998" promotor_-10 complement(2344653..2344672) /Source="Nicolas_upshift_promotors" /id="U2049" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=1760 /SigmaFactorBS="atacggaaaaagatgattatttacatcattcagAGTTGATTt taggttcttttgaACTTATAATGTTATATATACtgttttttgtttattcaataaatat t" /listShort="S998, yrkA, S997, bltR, yrkB, S996, yrkC, S995" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2344667) /Source="Nicolas_upshifts" /id="U2049" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=1760 /SigmaFactorBS="atacggaaaaagatgattatttacatcattcagAGTTGATTt taggttcttttgaACTTATAATGTTATATATACtgttttttgtttattcaataaatat t" /listShort="S998, yrkA, S997, bltR, yrkB, S996, yrkC, S995" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2344687..2344694) /Source="Nicolas_upshift_promotors" /id="U2049" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=1760 /SigmaFactorBS="atacggaaaaagatgattatttacatcattcagAGTTGATTt taggttcttttgaACTTATAATGTTATATATACtgttttttgtttattcaataaatat t" /listShort="S998, yrkA, S997, bltR, yrkB, S996, yrkC, S995" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2344850..2344993) /gene="yrzO" /locus_tag="BSU_26619" /old_locus_tag="BSU26619" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097765.1" /db_xref="EnsemblGenomes-Gn:BSU26619" /db_xref="EnsemblGenomes-Tr:CAX52668" /db_xref="InterPro:IPR025417" /db_xref="UniProtKB/Swiss-Prot:C0H458" /translation="MFEGLLFFISAGIVCELAAINRNGRKNIKQQAELIQILKENLYK DIK*" /label="yrzO CDS" gene complement(2344850..2344993) /gene="yrzO" /locus_tag="BSU_26619" /old_locus_tag="BSU26619" /label="yrzO gene" CDS complement(2345011..2345976) /gene="yrdR" /locus_tag="BSU_26620" /old_locus_tag="BSU26620" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_390539.1" /db_xref="EnsemblGenomes-Gn:BSU26620" /db_xref="EnsemblGenomes-Tr:CAB14603" /db_xref="GOA:O07086" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG12289" /db_xref="UniProtKB/Swiss-Prot:O07086" /translation="MKKGQLFIGALTCLVASMSWGAMFPVADHALEFVDPFYFSFIRY GVVTIMLVILLLVREGKKSFHLEGKAKWIILFGVMAFTIYNVLIFLGQRLMGKSGIMT ASIAEALMPMLSIVILWGYKHVKPKKYTMISILIAFLGASMVITKGNISFFFSLGDHL FSILFIFIGVLGWVVYTMGGQIFREWSTLRYSTLTCLFGTAITGIMTAILTAQGYVSV PSIKVIAAIKYDFLFMITLPGIIALLSWNYGIKILSSINGILFINFVPITTLLIMVIK GYNITAFDIVGTLFVIIGLILNNIYQRKEDYKQVLQKEKTNLTIT*" /label="yrdR CDS" gene complement(2345011..2345976) /gene="yrdR" /locus_tag="BSU_26620" /old_locus_tag="BSU26620" /label="yrdR gene" promotor_-35 2346014..2346017 /Source="Nicolas_upshift_promotors" /id="U2050" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.601398601398601" /psig="0.905094905094905" /xcortree=1788 /SigmaFactorBS="aaattacaatgagaaTTATaaaaagaagtaagcATCAAGTAA AATGAACAAAAgtgatgaaaaacatcattgataatgatactttaatgaaggggggatc t" /listShort="yrdQ, S999" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2346032..2346051 /Source="Nicolas_upshift_promotors" /id="U2050" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.601398601398601" /psig="0.905094905094905" /xcortree=1788 /SigmaFactorBS="aaattacaatgagaaTTATaaaaagaagtaagcATCAAGTAA AATGAACAAAAgtgatgaaaaacatcattgataatgatactttaatgaaggggggatc t" /listShort="yrdQ, S999" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2346059 /Source="Nicolas_upshifts" /id="U2050" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.601398601398601" /psig="0.905094905094905" /xcortree=1788 /SigmaFactorBS="aaattacaatgagaaTTATaaaaagaagtaagcATCAAGTAA AATGAACAAAAgtgatgaaaaacatcattgataatgatactttaatgaaggggggatc t" /listShort="yrdQ, S999" /GFF_Attribute="listLong" /label="upshifts" CDS 2346102..2346968 /gene="czcR" /locus_tag="BSU_26630" /old_locus_tag="BSU26630" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 22666466, 25437189; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (LysR family)" /protein_id="NP_390540.1" /db_xref="EnsemblGenomes-Gn:BSU26630" /db_xref="EnsemblGenomes-Tr:CAB14604" /db_xref="GOA:P71025" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12288" /db_xref="UniProtKB/Swiss-Prot:P71025" /translation="MELRDLQIFKCVAHHKSITGAAKELNYVQSNVTARIKQLENELK TPLFNRHKKGVSLSPEGRKMIEYVNKILKDVEELEQVFLDTEIPSGILKIGTVETVRI LPTIIASYYKKYPNVDLSLQAGLTEELIKKVMNHELDGAFISGPLKHSILEQYDVYTE KLTLVTSNKTFNIEDFSTTPILVFNQGCGYRSRLEQWLKDEGVLPNRMMEFNILETIL NSVALGLGITVVPESAVMHLAVQGKVYCHPLPEKDSCISTIFIRHKDAYLTNSMRSLL KTIVEHKNMSMA*" /label="czcR CDS" gene 2346102..2346968 /gene="czcR" /locus_tag="BSU_26630" /old_locus_tag="BSU26630" /label="czcR gene" S_feature 2346969..2347069 /Source="Nicolas_S_feature" /locus_tag="new_2722645_2722745" /HighExp="HiTm, dia15, LBGstat, LPhT, T0.30H, Diami, Paraq, dia5, H2O2, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.905" /TUlongSig="NA" /TUlongPSig="NA" /label="S999" downshifts 2347027 /Source="Nicolas_upshifts" /id="D1364" /incds=0 /nref=6 /ntot=135 /MaxReadThrough="2.57006" /MaxDrop="3.43983" /score="-6.36950065" /energy="-7" /TU="NA" /idTUdmin="U2050" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2347091..2348128) /gene="yrdP" /locus_tag="BSU_26640" /old_locus_tag="BSU26640" /EC_number="1.14.-.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9099864, 12100555, 12527699; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_390541.1" /db_xref="EnsemblGenomes-Gn:BSU26640" /db_xref="EnsemblGenomes-Tr:CAB14605" /db_xref="GOA:O07085" /db_xref="InterPro:IPR000103" /db_xref="InterPro:IPR000960" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG11980" /db_xref="UniProtKB/Swiss-Prot:O07085" /translation="MYDTIVIGAGQAGISIGYYLKQSDQKFIILDKSHEVGESWKDRY DSLVLFTSRMYSSLPGMHLEGEKHGFPSKNEIVAYLKKYVKKFEIPIQLRTEVISVLK IKNYFLIKTNREEYQTKNLVIATGPFHTPNIPSISKDLSDNINQLHSSQYKNSKQLAY GNVLVVGGGNSGAQIAVELSKERVTYLACSNKLVYFPLMIGKRSIFWWFDKLGVLHAS HTSIVGKFIQKKGDPVFGHELKHAIKQKEIILKKRVIAAKQNEIIFKDSSTLEVNNII WATGFRNPLCWINIKGVLDQEGRIIHHRGVSPVEGLYFIGLPWQHKRGSALLQGVGND AEYIVKQMNGE*" /label="yrdP CDS" gene complement(2347091..2348128) /gene="yrdP" /locus_tag="BSU_26640" /old_locus_tag="BSU26640" /label="yrdP gene" downshifts complement(2347103) /Source="Nicolas_upshifts" /id="D1365" /incds=0 /nref=30 /ntot=134 /MaxReadThrough="2.50972" /MaxDrop="5.83595" /score="2.19797168" /energy="-12.5" /TU="NA" /idTUdmin="U2051" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2348129..2348215) /Source="Nicolas_S_feature" /locus_tag="new_2723805_2723891_c" /HighExp="LBGtran, dia5, Gly, Diami, LBGstat, M0t45, LBGexp, Lbtran, dia0, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.907, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1000" CDS complement(2348216..2349151) /gene="czcD" /locus_tag="BSU_26650" /old_locus_tag="BSU26650" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10735849, 12100555, 15849754, 15948947, 16850406, 22447126, 26787764, 27210016" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10735849, 12100555, 15849754, 15948947, 16850406, 22447126, 26787764, 27210016; Product type t: transporter" /codon_start=1 /transl_table=11 /product="potassium/proton-divalent cation antiporter" /protein_id="NP_390542.1" /db_xref="EnsemblGenomes-Gn:BSU26650" /db_xref="EnsemblGenomes-Tr:CAB14606" /db_xref="GOA:O07084" /db_xref="InterPro:IPR002524" /db_xref="InterPro:IPR027469" /db_xref="InterPro:IPR027470" /db_xref="InterPro:IPR036837" /db_xref="SubtiList:BG11931" /db_xref="UniProtKB/Swiss-Prot:O07084" /translation="MGHNHNEGANKKVLLISFIMITGYMIIEAIGGFLTNSLALLSDA GHMLSDSISLMVALIAFTLAEKKANHNKTFGYKRFEILAAVINGAALILISLYIIYEA IERFSNPPKVATTGMLTISIIGLVVNLLVAWIMMSGGDTKNNLNIRGAYLHVISDMLG SVGAILAAILIIFFGWGWADPLASIIVAILVLRSGYNVTKDSIHILMEGTPENIDVSD IIRTIEGTEGIQNIHDLHIWSITSGLNALSCHAVVDDQLTISESENILRKIEHELEHK GITHVTIQMETEAHNHDNAILCQPKMEKQRDHHHH*" /label="czcD CDS" gene complement(2348216..2349151) /gene="czcD" /locus_tag="BSU_26650" /old_locus_tag="BSU26650" /label="czcD gene" promotor_-10 complement(2349186..2349205) /Source="Nicolas_upshift_promotors" /id="U2051" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig="0.907092907092907" /xcortree=1543 /SigmaFactorBS="ctcatatataaatattatttgtatcaTGTTAGAAtgcttcat aacagaTTTGAAATAATAAATACATAtgtattaaaaactttaggtaaggaggagtttt t" /listShort="czcD, S1000, yrdP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2349193) /Source="Nicolas_upshifts" /id="U2051" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig="0.907092907092907" /xcortree=1543 /SigmaFactorBS="ctcatatataaatattatttgtatcaTGTTAGAAtgcttcat aacagaTTTGAAATAATAAATACATAtgtattaaaaactttaggtaaggaggagtttt t" /listShort="czcD, S1000, yrdP" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2349195..2349278) /Source="Nicolas_S_feature" /locus_tag="new_2724871_2724954_c" /HighExp="dia5, Gly, LBGtran, Diami, LBGstat, LBGexp, LoTm, dia0, Lbexp, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1001" promotor_-35 complement(2349220..2349227) /Source="Nicolas_upshift_promotors" /id="U2051" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig="0.907092907092907" /xcortree=1543 /SigmaFactorBS="ctcatatataaatattatttgtatcaTGTTAGAAtgcttcat aacagaTTTGAAATAATAAATACATAtgtattaaaaactttaggtaaggaggagtttt t" /listShort="czcD, S1000, yrdP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2349259..2349278) /Source="Nicolas_upshift_promotors" /id="U2052" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.546453546453546" /psig=1 /xcortree=1541 /SigmaFactorBS="gaataattaaggaggtattgtggatttctataaaaatatTTT GACATttcagtaaagagcAGATATATTTATATATGAACacatgctcatatataaatat t" /listShort="S1001, czcD, S1000, yrdP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2349278) /Source="Nicolas_upshifts" /id="U2052" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.546453546453546" /psig=1 /xcortree=1541 /SigmaFactorBS="gaataattaaggaggtattgtggatttctataaaaatatTTT GACATttcagtaaagagcAGATATATTTATATATGAACacatgctcatatataaatat t" /listShort="S1001, czcD, S1000, yrdP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2349292..2349299) /Source="Nicolas_upshift_promotors" /id="U2052" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.546453546453546" /psig=1 /xcortree=1541 /SigmaFactorBS="gaataattaaggaggtattgtggatttctataaaaatatTTT GACATttcagtaaagagcAGATATATTTATATATGAACacatgctcatatataaatat t" /listShort="S1001, czcD, S1000, yrdP" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2349413) /Source="Nicolas_upshifts" /id="D1366" /incds=0 /nref=1 /ntot=41 /MaxReadThrough="3.75163" /MaxDrop="3.57795" /score="38.5313506" /energy="-18.1" /TU="NA" /idTUdmin="U2051" /TUdmin="-2310" /isTUend="FALSE" /label="downshifts" CDS complement(2349438..2349827) /gene="yrdN" /locus_tag="BSU_26660" /old_locus_tag="BSU26660" /EC_number="5.3.2.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative tautomerase" /protein_id="NP_390543.1" /db_xref="EnsemblGenomes-Gn:BSU26660" /db_xref="EnsemblGenomes-Tr:CAB14607" /db_xref="GOA:P94502" /db_xref="InterPro:IPR004370" /db_xref="InterPro:IPR014347" /db_xref="SubtiList:BG12287" /db_xref="UniProtKB/Swiss-Prot:P94502" /translation="MPLLRFDLIEGRDQSSLKKLLDVAHNVVVEAFDVPQQDRYQIVH EHPENHMIIEDTGLGFNRTKNLVVLSVTSKSRPEEKKQKFYRLLAERLESECGIASTD LIVSIVENDNADWSFGLGEAQFLTGKL*" /label="yrdN CDS" gene complement(2349438..2349827) /gene="yrdN" /locus_tag="BSU_26660" /old_locus_tag="BSU26660" /label="yrdN gene" promotor_-35 2350075..2350082 /Source="Nicolas_upshift_promotors" /id="U2053" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.525474525474525" /psig="0.998001998001998" /xcortree=2368 /SigmaFactorBS="ttagaaatcatttattcttctaagctttAGTTTACAtgaagc tctgctatcATATATAATTCAAAATTAAGatggaagacatctcaaaatcagatatcaa c" /listShort="gltR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2350098..2350117 /Source="Nicolas_upshift_promotors" /id="U2053" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.525474525474525" /psig="0.998001998001998" /xcortree=2368 /SigmaFactorBS="ttagaaatcatttattcttctaagctttAGTTTACAtgaagc tctgctatcATATATAATTCAAAATTAAGatggaagacatctcaaaatcagatatcaa c" /listShort="gltR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2350107 /Source="Nicolas_upshifts" /id="U2053" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.525474525474525" /psig="0.998001998001998" /xcortree=2368 /SigmaFactorBS="ttagaaatcatttattcttctaagctttAGTTTACAtgaagc tctgctatcATATATAATTCAAAATTAAGatggaagacatctcaaaatcagatatcaa c" /listShort="gltR" /GFF_Attribute="listLong" /label="upshifts" CDS 2350161..2351051 /gene="gltR" /locus_tag="BSU_26670" /old_locus_tag="BSU26670" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9023181, 28294562" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9023181, 28294562; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (LysR family)" /protein_id="NP_390544.2" /db_xref="EnsemblGenomes-Gn:BSU26670" /db_xref="EnsemblGenomes-Tr:CAB14608" /db_xref="GOA:P94501" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11942" /db_xref="UniProtKB/Swiss-Prot:P94501" /translation="MNIQLLQVFLTTAREGSISKAALTLNYAQSNVTNKIQQLENDLQ TKLFYRHSRGITLTPPGQILVSYSEKILHTIEEARAAMGESSAPSGPLRIGSMETTAA VWLPQLLAHYNNLYPNVDLNLVTGPTEQQIQAVLHYELNGAFISGPIEHPDLVQEKVL DEEMVLVTSASHPVISSIQDVQTQTMLVFRKGCSYRAKLNHILQEEGLLPIKLMEFGI LEAIIGCVSAGLGISLLPRSIIASHEKEGRIRSHTISDKYSFVSTMFIRRKDTLITPA LSAFLTHMRDHFQIKRPDQS*" /label="gltR CDS" gene 2350161..2351051 /gene="gltR" /locus_tag="BSU_26670" /old_locus_tag="BSU26670" /label="gltR gene" promotor_-35 2350739..2350744 /Source="Nicolas_upshift_promotors" /id="U2054" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1013 /SigmaFactorBS="acacaaacaatgcttgtattccgtaaaggatgCTCATAcaga gcaaagctcaaTCATATCCTGCAAGAAGAAggtttattacctataaaattaatggaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2350760..2350778 /Source="Nicolas_upshift_promotors" /id="U2054" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1013 /SigmaFactorBS="acacaaacaatgcttgtattccgtaaaggatgCTCATAcaga gcaaagctcaaTCATATCCTGCAAGAAGAAggtttattacctataaaattaatggaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2350767 /Source="Nicolas_upshifts" /id="U2054" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1013 /SigmaFactorBS="acacaaacaatgcttgtattccgtaaaggatgCTCATAcaga gcaaagctcaaTCATATCCTGCAAGAAGAAggtttattacctataaaattaatggaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2351209..2351526) /gene="yrdK" /locus_tag="BSU_26680" /old_locus_tag="BSU26680" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_390545.3" /db_xref="EnsemblGenomes-Gn:BSU26680" /db_xref="EnsemblGenomes-Tr:CAB14609" /db_xref="SubtiList:BG12286" /db_xref="UniProtKB/Swiss-Prot:P94500" /translation="MRLYTEYIPNKNKLINQQQYHSDLQDLLHQWILQLLQLDVLPLS NRKYQSSRCHPKSVGEYLIVVRAIDALGNSQPLTSRRNQVSRAMTFVQNSLNEENLHP NID*" /label="yrdK CDS" gene complement(2351209..2351526) /gene="yrdK" /locus_tag="BSU_26680" /old_locus_tag="BSU26680" /label="yrdK gene" CDS complement(2351484..2352806) /gene="brnQ" /locus_tag="BSU_26690" /old_locus_tag="BSU26690" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8544834, 9287000, 9531631, 15849754, 16850406, 25645558" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8544834, 9287000, 9531631, 15849754, 16850406, 25645558; Product type t : transporter" /codon_start=1 /transl_table=11 /product="low-affinity branched-chain amino acid transporter" /protein_id="NP_390546.1" /db_xref="EnsemblGenomes-Gn:BSU26690" /db_xref="EnsemblGenomes-Tr:CAB14610" /db_xref="GOA:P94499" /db_xref="InterPro:IPR004685" /db_xref="SubtiList:BG11918" /db_xref="UniProtKB/Swiss-Prot:P94499" /translation="MSKKVSASYIIIIGLMLFALFFGAGNLIFPPMLGQLAGKNVWVA NAGFLVTGVGLPLLAITAFVFSGKQNLQSLASRVHPVFGIVFTTILYLAIGPFFAIPR SGNVSFEIGVKPFLSNDASPVSLIIFTILFFALACLLSLNPSKIIDIVGKFLTPIKLT FIGLLVAVALIRPIGTIQAPSKGYTSQAFFKGFQEGYLTLDALVAFVFGIIIVNALKE QGASTKKQLIVVCAKAAAIAAVLLAVMYTALSYMGASSVEELGILENGAEVLAKVSSY YFGSYGSILLGLMITVACLTTSVGLITACSSFFHELFPNISYKKIAVVLSVFSTLVAN IGLTQLIKVSMPVLLTMYPIAISLIFLTFLHSVFKGKTEVYQGSLLFAFIISLFDGLK AAGIKIEVVNRIFTQILPMYNIGLGWLIPAIAGGICGYILSIFRTKTS*" /label="brnQ CDS" gene complement(2351484..2352806) /gene="brnQ" /locus_tag="BSU_26690" /old_locus_tag="BSU26690" /label="brnQ gene" CDS complement(2352971..2353303) /gene="azlD" /locus_tag="BSU_26700" /old_locus_tag="BSU26700" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9287000, 25645558" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9287000, 25645558; Product type t: transporter" /codon_start=1 /transl_table=11 /product="branched-chain amino acid / methionine exporter" /protein_id="NP_390547.1" /db_xref="EnsemblGenomes-Gn:BSU26700" /db_xref="EnsemblGenomes-Tr:CAB14611" /db_xref="GOA:O07923" /db_xref="InterPro:IPR008407" /db_xref="SubtiList:BG11916" /db_xref="UniProtKB/Swiss-Prot:O07923" /translation="MTMTMTQQMITIAMVVLGTMLTRFLPFMIFPSGKPTPKYVQYLG KVLPSAVIGLLVIYCLKDVSLLSGSHGIPELVGAAAVVLLHLWKKNMLLSIAGGTVVY MVLVQLVF*" /label="azlD CDS" gene complement(2352971..2353303) /gene="azlD" /locus_tag="BSU_26700" /old_locus_tag="BSU26700" /label="azlD gene" CDS complement(2353300..2354064) /gene="azlC" /locus_tag="BSU_26710" /old_locus_tag="BSU26710" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9287000, 15849754, 16850406, 25645558" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9287000, 15849754, 16850406, 25645558; Product type t: transporter" /codon_start=1 /transl_table=11 /product="branched-chain amino acid / methionine exporter" /protein_id="NP_390548.1" /db_xref="EnsemblGenomes-Gn:BSU26710" /db_xref="EnsemblGenomes-Tr:CAB14612" /db_xref="GOA:O07942" /db_xref="InterPro:IPR004471" /db_xref="InterPro:IPR011606" /db_xref="SubtiList:BG11915" /db_xref="UniProtKB/Swiss-Prot:O07942" /translation="MNKNKESLHLSSPAINTHMNKRSQIWAAFRSAFPYTIPIFAGFL FLGIAYGIFMHSLGFSAIYPIIMSFMIFAGSMEFVAANFLLGAFNPMNALFLTLMVNA RHLFYGISMLDKYRGTGKKKLYLIFGMCDESFSINYTANVPANVDKGWFMFFVTLLNH LYWVAGAAIGGIFGSYVKFNTEGLDFVMTALFIVIFIEQWMKEKKHYSALTGLGLSVA SLILFGGNQFIIPAMLAILGVLTVLRKPLEKAEVSV*" /label="azlC CDS" gene complement(2353300..2354064) /gene="azlC" /locus_tag="BSU_26710" /old_locus_tag="BSU26710" /label="azlC gene" CDS complement(2354077..2354550) /gene="azlB" /locus_tag="BSU_26720" /old_locus_tag="BSU26720" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9023181, 9287000, 26473603" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9023181, 9287000, 26473603; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of the azlBCD operon" /protein_id="NP_390549.1" /db_xref="EnsemblGenomes-Gn:BSU26720" /db_xref="EnsemblGenomes-Tr:CAB14613" /db_xref="GOA:O07920" /db_xref="InterPro:IPR000485" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR019885" /db_xref="InterPro:IPR019887" /db_xref="InterPro:IPR019888" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11914" /db_xref="UniProtKB/Swiss-Prot:O07920" /translation="MGIMLDETDKAILRDLQEDASISNLNLSKKIGLSPSACLARTKN LVEAGIIKKFTTIVDEKKLGIEVTALALINLSPLNRETIHSFLEDINKFPQVQECYTL TGSHDYMLKIVAKDMESYRNFIIDSLMQNPAISGVDTSIVMSTEKRTVSVPIDEM*" /label="azlB CDS" gene complement(2354077..2354550) /gene="azlB" /locus_tag="BSU_26720" /old_locus_tag="BSU26720" /label="azlB gene" CDS complement(2354884..2355159) /gene="yrdF" /locus_tag="BSU_26730" /old_locus_tag="BSU26730" /function="16.8: Protect" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative ribonuclease inhibitor" /protein_id="NP_390550.1" /db_xref="EnsemblGenomes-Gn:BSU26730" /db_xref="EnsemblGenomes-Tr:CAB14614" /db_xref="GOA:O07938" /db_xref="InterPro:IPR000468" /db_xref="InterPro:IPR035905" /db_xref="SubtiList:BG12285" /db_xref="UniProtKB/Swiss-Prot:O07938" /translation="MRKIIIDGRDFENIEVLHDDLKDKLDFPDYYGRNLDALWDCLTG WVDLPLTLVLKNFEFSNTFLGSYADDVLEVIQEAQEELKDEFKIIIE*" /label="yrdF CDS" gene complement(2354884..2355159) /gene="yrdF" /locus_tag="BSU_26730" /old_locus_tag="BSU26730" /label="yrdF gene" misc_feature complement(2355171..2355190) /Source="Nicolas_upshift_promotors" /id="U2055" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.881118881118881" /psig="0.972027972027972" /xcortree=3056 /SigmaFactorBS="ttttcagcctcatttggacaaacagctgttacatagtaaacg tttgtTAAGATAAAATAATGGAGGGcatagtttctaatgagaaaaataataatagatg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2355177) /Source="Nicolas_upshifts" /id="U2055" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.881118881118881" /psig="0.972027972027972" /xcortree=3056 /SigmaFactorBS="ttttcagcctcatttggacaaacagctgttacatagtaaacg tttgtTAAGATAAAATAATGGAGGGcatagtttctaatgagaaaaataataatagatg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2355245..2355430) /Source="Nicolas_S_feature" /locus_tag="new_2730921_2731106_c" /HighExp="BT, S4, S8, S3, S5, S7, S6, LoTm, B36, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.977" /TUlongSig="NA" /TUlongPSig="NA" /label="S1002" CDS complement(2355431..2356663) /gene="cypA" /locus_tag="BSU_26740" /old_locus_tag="BSU26740" /EC_number="1.14.-.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9778370, 12354229, 28898812" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9778370, 12354229, 28898812; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome P450" /protein_id="NP_390551.1" /db_xref="EnsemblGenomes-Gn:BSU26740" /db_xref="EnsemblGenomes-Tr:CAB14615" /db_xref="GOA:O08469" /db_xref="InterPro:IPR001128" /db_xref="InterPro:IPR002397" /db_xref="InterPro:IPR017972" /db_xref="InterPro:IPR036396" /db_xref="SubtiList:BG11929" /db_xref="UniProtKB/Swiss-Prot:O08469" /translation="MSSKEKKSVTILTESQLSSRAFKDEAYEFYKELRKSQALYPLSL GALGKGWLISRYDDAIHLLKNEKLKKNYENVFTAKEKRPALLKNEETLTKHMLNSDPP DHNRLRTLVQKAFTHRMILQLEDKIQHIADSLLDKVQPNKFMNLVDDYAFPLPIIVIS EMLGIPLEDRQKFRVWSQAIIDFSDAPERLQENDHLLGEFVEYLESLVRKKRREPAGD LISALIQAESEGTQLSTEELYSMIMLLIVAGHETTVNLITNMTYALMCHHDQLEKLRQ QPDLMNSAIEEALRFHSPVELTTIRWTAEPFILHGQEIKRKDVIIISLASANRDEKIF PNADIFDIERKNNRHIAFGHGNHFCLGAQLARLEAKIAISTLLRRCPNIQLKGEKKQM KWKGNFLMRALEELPISF*" /label="cypA CDS" gene complement(2355431..2356663) /gene="cypA" /locus_tag="BSU_26740" /old_locus_tag="BSU26740" /label="cypA gene" CDS complement(2356713..2356871) /gene="yrdDc" /locus_tag="BSU_26748" /old_locus_tag="BSU26748" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein; C-terminal part of YrdD" /db_xref="PSEUDO:CAX52669.1" /translation="MEVLGVSPFYQGKSLGSKMINDCLISFISKCGDGILALIMNTDL NGSFYKSS*" /label="yrdDc CDS" gene complement(2356713..2356871) /gene="yrdDc" /locus_tag="BSU_26748" /old_locus_tag="BSU26748" /pseudo /label="yrdDc gene" CDS complement(2356868..2357071) /gene="yrdDm" /locus_tag="BSU_26749" /old_locus_tag="BSU26749" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein; internal part of YrdD" /db_xref="SubtiList:BG12284" /translation="MHKVLTRAYFKKHFFFVGIQNGEMVVAALLKHRDKPDIKLDRLY SSRGDNINQNGAKKFSKSLKEPA*" /label="yrdDm CDS" gene complement(2356868..2357071) /gene="yrdDm" /locus_tag="BSU_26749" /old_locus_tag="BSU26749" /pseudo /label="yrdDm gene" promotor_-10 complement(2357032..2357050) /Source="Nicolas_upshift_promotors" /id="U2056" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1116 /SigmaFactorBS="gtaaaacgcgaaaaaaagatcattcatttatttttgaaaTGC ATAaagtactgacaagaGCATATTTTAAAAAGCATTtcttttttgttggcattcagaa t" /listShort="yrdD, yrdD, cypA, S1002" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2357049) /Source="Nicolas_upshifts" /id="U2056" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1116 /SigmaFactorBS="gtaaaacgcgaaaaaaagatcattcatttatttttgaaaTGC ATAaagtactgacaagaGCATATTTTAAAAAGCATTtcttttttgttggcattcagaa t" /listShort="yrdD, yrdD, cypA, S1002" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2357056..2357205) /gene="yrdDn" /locus_tag="BSU_26750" /old_locus_tag="BSU26750" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein; N-terminal part of YrdD" /db_xref="SubtiList:BG14036" /translation="MFLYRQARADEVSKVAKLFHQSFNQYPFMDLLVKREKKIIHLFL KCIKY*" /label="yrdDn CDS" gene complement(2357056..2357205) /gene="yrdDn" /locus_tag="BSU_26750" /old_locus_tag="BSU26750" /pseudo /label="yrdDn gene" promotor_-35 complement(2357065..2357070) /Source="Nicolas_upshift_promotors" /id="U2056" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1116 /SigmaFactorBS="gtaaaacgcgaaaaaaagatcattcatttatttttgaaaTGC ATAaagtactgacaagaGCATATTTTAAAAAGCATTtcttttttgttggcattcagaa t" /listShort="yrdD, yrdD, cypA, S1002" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2357289) /Source="Nicolas_upshifts" /id="D1367" /incds=0 /nref=140 /ntot=216 /MaxReadThrough="2.2276" /MaxDrop="4.5127" /score="5.01317133" /energy="-16.7" /TU="NA" /idTUdmin="U2057" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2357304..2357867) /gene="yrdC" /locus_tag="BSU_26760" /old_locus_tag="BSU26760" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390553.1" /db_xref="EnsemblGenomes-Gn:BSU26760" /db_xref="EnsemblGenomes-Tr:CAB14617" /db_xref="GOA:O07081" /db_xref="InterPro:IPR000868" /db_xref="InterPro:IPR036380" /db_xref="SubtiList:BG12283" /db_xref="UniProtKB/Swiss-Prot:O07081" /translation="MEEKKALIIVDVQKAFDDKKWGERNNVKAEENISKILELWREKG WTVIYIQHTSDKPHSLFHPKNEGFAIKEIVKPMDEEVIITKTVNSSFIGTNLEEFLKL NEITTVVITGLTTPHCVSTTTRMSGNLGFDTYLISDATAAFGMRDQNDTYYDAATIHN ISLATLHDEFATILTTDQLINDFIKTH*" /label="yrdC CDS" gene complement(2357304..2357867) /gene="yrdC" /locus_tag="BSU_26760" /old_locus_tag="BSU26760" /label="yrdC gene" downshifts 2357785 /Source="Nicolas_upshifts" /id="D1368" /incds=1 /nref=44 /ntot=194 /MaxReadThrough="1.72227" /MaxDrop="3.37915" /score="14.6499034" /energy="-6.6" /TU="NA" /idTUdmin="U2060" /TUdmin="-4488" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2357897..2357916) /Source="Nicolas_upshift_promotors" /id="U2057" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.856143856143856" /psig="0.997002997002997" /xcortree=2342 /SigmaFactorBS="ggcgctcatttgaaattcatcattaaaCAATTGTAcaaaagt aaaatttGTATTTAGAATGTAGTAATAaatagaaattctacgtaggagggtatcttgt g" /listShort="yrdC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2357905) /Source="Nicolas_upshifts" /id="U2057" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.856143856143856" /psig="0.997002997002997" /xcortree=2342 /SigmaFactorBS="ggcgctcatttgaaattcatcattaaaCAATTGTAcaaaagt aaaatttGTATTTAGAATGTAGTAATAaatagaaattctacgtaggagggtatcttgt g" /listShort="yrdC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2357931..2357938) /Source="Nicolas_upshift_promotors" /id="U2057" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.856143856143856" /psig="0.997002997002997" /xcortree=2342 /SigmaFactorBS="ggcgctcatttgaaattcatcattaaaCAATTGTAcaaaagt aaaatttGTATTTAGAATGTAGTAATAaatagaaattctacgtaggagggtatcttgt g" /listShort="yrdC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2358096..2358467) /gene="yrdB" /locus_tag="BSU_26770" /old_locus_tag="BSU26770" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390554.1" /db_xref="EnsemblGenomes-Gn:BSU26770" /db_xref="EnsemblGenomes-Tr:CAB14618" /db_xref="GOA:O07080" /db_xref="InterPro:IPR021214" /db_xref="SubtiList:BG12282" /db_xref="UniProtKB/Swiss-Prot:O07080" /translation="MEKLNQTNLLLRFTLEIAALISLGVYAWISFNGYFKYVLTLVLP IAVMIVWSVFAVPHDPSRSGQTVIAVNGVTRLVIELLIFAMAVAALYFSYLKPVSIVF LCLIILHYIISAERIKWLLNQ*" /label="yrdB CDS" gene complement(2358096..2358467) /gene="yrdB" /locus_tag="BSU_26770" /old_locus_tag="BSU26770" /label="yrdB gene" S_feature complement(2358468..2358697) /Source="Nicolas_S_feature" /locus_tag="new_2734144_2734373_c" /HighExp="BMM, GM 120, GM 90, SMM, MG 150, GM 60, MG 120, M9-tran, Glu, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.48162700000000003" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1003" promotor_-10 complement(2358679..2358698) /Source="Nicolas_upshift_promotors" /id="U2058" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=3041 /SigmaFactorBS="gtataatctttacttcgttcgacaaattctgcaaatTGTAGA CAacttcctgattatTTGGATAATTAACTGAATAGgaggggaaaagttgtcatatttc a" /listShort="S1003, yrdB" /listLong="yrdC" /label="promotor_-10" upshifts complement(2358695) /Source="Nicolas_upshifts" /id="U2058" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=3041 /SigmaFactorBS="gtataatctttacttcgttcgacaaattctgcaaatTGTAGA CAacttcctgattatTTGGATAATTAACTGAATAGgaggggaaaagttgtcatatttc a" /listShort="S1003, yrdB" /listLong="yrdC" /label="upshifts" promotor_-35 complement(2358712..2358719) /Source="Nicolas_upshift_promotors" /id="U2058" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=3041 /SigmaFactorBS="gtataatctttacttcgttcgacaaattctgcaaatTGTAGA CAacttcctgattatTTGGATAATTAACTGAATAGgaggggaaaagttgtcatatttc a" /listShort="S1003, yrdB" /listLong="yrdC" /label="promotor_-35" downshifts complement(2359263) /Source="Nicolas_upshifts" /id="D1369" /incds=0 /nref=174 /ntot=248 /MaxReadThrough="2.42722" /MaxDrop="5.81863" /score="7.90390368" /energy="-10.3" /TU="NA" /idTUdmin="U2059" /TUdmin=6 /isTUend="TRUE" /label="downshifts" CDS complement(2359277..2359780) /gene="yrdA" /locus_tag="BSU_26780" /old_locus_tag="BSU26780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390555.1" /db_xref="EnsemblGenomes-Gn:BSU26780" /db_xref="EnsemblGenomes-Tr:CAB14619" /db_xref="GOA:O07079" /db_xref="InterPro:IPR007837" /db_xref="InterPro:IPR034660" /db_xref="SubtiList:BG12281" /db_xref="UniProtKB/Swiss-Prot:O07079" /translation="MFQTLDHFLKSWEFEADATQKLLNSLTDESLKQEITSQNWTLGR IAWHTVAAIGIITSNTDLTFQAPAEDYPVPTSAQFIADSYHQASNAFVQALKTQWTDH TLQERINFIGQQMPNGSLLMFLIQHQNHHRGQMTVLMRQAGLTVPGIYGPAKEEWAKF GLEAPKM*" /label="yrdA CDS" gene complement(2359277..2359780) /gene="yrdA" /locus_tag="BSU_26780" /old_locus_tag="BSU26780" /label="yrdA gene" S_feature complement(2359781..2360005) /Source="Nicolas_S_feature" /locus_tag="new_2735457_2735681_c" /HighExp="Etha, Lbstat, M0t90, M40t90, LoTm, M9-stat, Gly, S2, T0.30H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1004" CDS complement(2360006..2360860) /gene="aadK" /locus_tag="BSU_26790" /old_locus_tag="BSU26790" /EC_number="2.7.7.-" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8293959" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8293959; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="aminoglycoside 6-adenylyltransferase" /protein_id="NP_390556.1" /db_xref="EnsemblGenomes-Gn:BSU26790" /db_xref="EnsemblGenomes-Tr:CAB14620" /db_xref="GOA:P17585" /db_xref="InterPro:IPR007530" /db_xref="PDB:2PBE" /db_xref="SubtiList:BG11037" /db_xref="UniProtKB/Swiss-Prot:P17585" /translation="MRSEQEMMDIFLDFALNDERIRLVTLEGSRTNRNIPPDNFQDYD ISYFVTDVESFKENDQWLEIFGKRIMMQKPEDMELFPPELGNWFSYIILFEDGNKLDL TLIPIREAEDYFANNDGLVKVLLDKDSFINYKVTPNDRQYWIKRPTAREFDDCCNEFW MVSTYVVKGLARNEILFAIDHLNEIVRPNLLRMMAWHIASQKGYSFSMGKNYKFMKRY LSNKEWEELMSTYSVNGYQEMWKSLFTCYALFRKYSKAVSEGLAYKYPDYDEGITKYT EGIYCSVK*" /label="aadK CDS" gene complement(2360006..2360860) /gene="aadK" /locus_tag="BSU_26790" /old_locus_tag="BSU26790" /label="aadK gene" S_feature complement(2360861..2360963) /Source="Nicolas_S_feature" /locus_tag="new_2736537_2736639_c" /HighExp="M9-stat, T3.0H, T0.30H, T1.30H, T2.30H, Lbtran, T3.30H, T1.0H, M0t90, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1005" promotor_-10 complement(2360944..2360963) /Source="Nicolas_upshift_promotors" /id="U2059" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.909090909090909" /psig="0.997002997002997" /xcortree=3219 /SigmaFactorBS="gttgatatctgattttgagatgtcttgcatcttaatattgAA TGatatataggagaacATCATGTAAAATAAAGCTTAgaagaatacatcacattcaaga g" /listShort="S1005, aadK, S1004, yrdA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2360961) /Source="Nicolas_upshifts" /id="U2059" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.909090909090909" /psig="0.997002997002997" /xcortree=3219 /SigmaFactorBS="gttgatatctgattttgagatgtcttgcatcttaatattgAA TGatatataggagaacATCATGTAAAATAAAGCTTAgaagaatacatcacattcaaga g" /listShort="S1005, aadK, S1004, yrdA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2360978..2360981) /Source="Nicolas_upshift_promotors" /id="U2059" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.909090909090909" /psig="0.997002997002997" /xcortree=3219 /SigmaFactorBS="gttgatatctgattttgagatgtcttgcatcttaatattgAA TGatatataggagaacATCATGTAAAATAAAGCTTAgaagaatacatcacattcaaga g" /listShort="S1005, aadK, S1004, yrdA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2361132..2361139 /Source="Nicolas_upshift_promotors" /id="U2060" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.723276723276723" /psig="0.894105894105894" /xcortree=2930 /SigmaFactorBS="atcgacatgttaactggtatgagaGATTGACAaaaagaagga aaaCGATATATTTAAGCGAATACgagtttttgagtaaattttaaaatgacactttttt c" /listShort="S1006, yrpB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2361153..2361172 /Source="Nicolas_upshift_promotors" /id="U2060" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.723276723276723" /psig="0.894105894105894" /xcortree=2930 /SigmaFactorBS="atcgacatgttaactggtatgagaGATTGACAaaaagaagga aaaCGATATATTTAAGCGAATACgagtttttgagtaaattttaaaatgacactttttt c" /listShort="S1006, yrpB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2361168 /Source="Nicolas_upshifts" /id="U2060" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.723276723276723" /psig="0.894105894105894" /xcortree=2930 /SigmaFactorBS="atcgacatgttaactggtatgagaGATTGACAaaaagaagga aaaCGATATATTTAAGCGAATACgagtttttgagtaaattttaaaatgacactttttt c" /listShort="S1006, yrpB" /GFF_Attribute="listLong" /label="upshifts" S_feature 2361173..2361238 /Source="Nicolas_S_feature" /locus_tag="new_2736849_2736914" /HighExp="LoTm, BC, S1, S2, C90, T4.0H, HiOs, T5.0H, T3.30H, SMMPr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.894" /TUlongSig="NA" /TUlongPSig="NA" /label="S1006" CDS 2361239..2362282 /gene="yrpB" /locus_tag="BSU_26800" /old_locus_tag="BSU26800" /EC_number="1.13.12.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9501443; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative anionic nitroalkane monoxygenase" /protein_id="NP_390557.1" /db_xref="EnsemblGenomes-Gn:BSU26800" /db_xref="EnsemblGenomes-Tr:CAB14621" /db_xref="GOA:O05413" /db_xref="InterPro:IPR004136" /db_xref="InterPro:IPR013785" /db_xref="SubtiList:BG12305" /db_xref="UniProtKB/Swiss-Prot:O05413" /translation="MNEFMKKFSLTKPIIQAPMAGGITKPRLASAVSNQGALGSLASG YLTPDLLEQQIKEIFELTDAPFQINVFVPLGLEMPPKDQIKKWKENIPLANQVNQFTS VQEEWDDFYQKIDLILKYKVKACSFTFDLPPEDAVKELKTAGCCLIGTASTVEEALLM EERGMDIVVLQGSEAGGHRGAFLPSKGESAVGLMALIPQAADALSVPVIAAGGMIDHR GVKAALTLGAQGVQIGSAFLICHESNAHPVHKQKILEANEADTKLTTLFSGKEARGIV NKWMEENEQFETQTLPYPYQNTLTKAMRQKASLQNNHDQMSLWAGQGIRSLTEEISVK QLLNQLCQEDIKI*" /label="yrpB CDS" gene 2361239..2362282 /gene="yrpB" /locus_tag="BSU_26800" /old_locus_tag="BSU26800" /label="yrpB gene" downshifts 2362280 /Source="Nicolas_upshifts" /id="D1370" /incds=0 /nref=22 /ntot=198 /MaxReadThrough="1.3622" /MaxDrop="5.04821" /score="14.6499034" /energy="-6.6" /TU="NA" /idTUdmin="U2060" /TUdmin=7 /isTUend="TRUE" /label="downshifts" promotor_-35 2362567..2362574 /Source="Nicolas_upshift_promotors" /id="U2061" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95904095904096" /psig=1 /xcortree=2015 /SigmaFactorBS="atcgatagctcccatattaaatttgaatagtaaaatggttct ttttCGTTTGATtcagatgatataaAGTCATATGATAAAAAAAGAatgagacagaaag c" /listShort="yrpC" /listLong="yrpD, S1007" /label="promotor_-35" upshifts 2362581 /Source="Nicolas_upshifts" /id="U2061" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95904095904096" /psig=1 /xcortree=2015 /SigmaFactorBS="atcgatagctcccatattaaatttgaatagtaaaatggttct ttttCGTTTGATtcagatgatataaAGTCATATGATAAAAAAAGAatgagacagaaag c" /listShort="yrpC" /listLong="yrpD, S1007" /label="upshifts" promotor_-10 2362588..2362607 /Source="Nicolas_upshift_promotors" /id="U2061" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95904095904096" /psig=1 /xcortree=2015 /SigmaFactorBS="atcgatagctcccatattaaatttgaatagtaaaatggttct ttttCGTTTGATtcagatgatataaAGTCATATGATAAAAAAAGAatgagacagaaag c" /listShort="yrpC" /listLong="yrpD, S1007" /label="promotor_-10" CDS 2362632..2363429 /gene="murI" /locus_tag="BSU_26810" /old_locus_tag="BSU26810" /EC_number="5.1.1.3" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12829290, 15212785, 15347750, 17720142, 25777674" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12829290, 15212785, 15347750, 17720142, 25777674; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate racemase" /protein_id="NP_390558.1" /db_xref="EnsemblGenomes-Gn:BSU26810" /db_xref="EnsemblGenomes-Tr:CAB14622" /db_xref="GOA:O05412" /db_xref="InterPro:IPR001920" /db_xref="InterPro:IPR004391" /db_xref="InterPro:IPR015942" /db_xref="InterPro:IPR018187" /db_xref="SubtiList:BG12306" /db_xref="UniProtKB/Swiss-Prot:O05412" /translation="MKIGFFDSGIGGMTVLYEAIKVLPYEDYIFYADTLNVPYGEKSK GKVKEYIFNAAEFLASQNIKALVIACNTATSIAIEDLRRNFDFPIIGIEPAVKPAINK CTEERKRVLVVATNLTLKEEKFHNLVKEIDHHDLVDCLALPGLVEFAENFDFSEDKII KYLKNELSSFDLKQYGTIVLGCTHFPFFKNSFEKLFGIKVDMISGSVGTAKQLKKVLA DRNQLGKGSGSITFFNSGHKIVDQEVISKYKRLFEILDETQRSHVGH*" /label="murI CDS" gene 2362632..2363429 /gene="murI" /locus_tag="BSU_26810" /old_locus_tag="BSU26810" /label="murI gene" promotor_-35 2363735..2363739 /Source="Nicolas_upshift_promotors" /id="U2062" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.304695304695305" /psig="0.997002997002997" /xcortree=3238 /SigmaFactorBS="gtgtaaattctgtatctatgtgcatgtttattATGGAattat tttcataaTGTTTTATAATACAAGATGAtagcgttttctaattataatgataggggga a" /listShort="yrpD, S1007, S1008, S1009, S1010" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2363753..2363772 /Source="Nicolas_upshift_promotors" /id="U2062" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.304695304695305" /psig="0.997002997002997" /xcortree=3238 /SigmaFactorBS="gtgtaaattctgtatctatgtgcatgtttattATGGAattat tttcataaTGTTTTATAATACAAGATGAtagcgttttctaattataatgataggggga a" /listShort="yrpD, S1007, S1008, S1009, S1010" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2363763 /Source="Nicolas_upshifts" /id="U2062" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.304695304695305" /psig="0.997002997002997" /xcortree=3238 /SigmaFactorBS="gtgtaaattctgtatctatgtgcatgtttattATGGAattat tttcataaTGTTTTATAATACAAGATGAtagcgttttctaattataatgataggggga a" /listShort="yrpD, S1007, S1008, S1009, S1010" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2363787..2363801) /Source="Nicolas_upshift_promotors" /id="U2063" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.921078921078921" /psig="0.070929070929071" /xcortree=302 /SigmaFactorBS="caaaaagcacggttgccgtaagcgcacccgcaagcagacctt ttttcATCATcattatttCCCCCTATCATTATAattagaaaacgctatcatcttgtat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2363801) /Source="Nicolas_upshifts" /id="U2063" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.921078921078921" /psig="0.070929070929071" /xcortree=302 /SigmaFactorBS="caaaaagcacggttgccgtaagcgcacccgcaagcagacctt ttttcATCATcattatttCCCCCTATCATTATAattagaaaacgctatcatcttgtat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2363810..2363814) /Source="Nicolas_upshift_promotors" /id="U2063" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.921078921078921" /psig="0.070929070929071" /xcortree=302 /SigmaFactorBS="caaaaagcacggttgccgtaagcgcacccgcaagcagacctt ttttcATCATcattatttCCCCCTATCATTATAattagaaaacgctatcatcttgtat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2363810..2364517 /gene="yrpD" /locus_tag="BSU_26820" /old_locus_tag="BSU26820" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 25355936; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_390559.1" /db_xref="EnsemblGenomes-Gn:BSU26820" /db_xref="EnsemblGenomes-Tr:CAB14623" /db_xref="InterPro:IPR029143" /db_xref="SubtiList:BG12307" /db_xref="UniProtKB/Swiss-Prot:O05411" /translation="MMKKGLLAGALTATVLFGTCAVDVPGIISPKTAEAASQLTDGIG GRAYLNSNGAILVTKIQLPSSTQVSNGTAYIYSGFSGGTESDIGFQYSDKYNVWKPYM KVGSKGQDQVQYLEGGSQFTNTKGFRPGSTVQLTIYKNLNGNTRATYWGTNNAGYNGR LISEISKTNVGSISKWKALATVATTGSRQSIKSNFSTSFTNITIDNKAITPVIDTQDF AKVTVSGNSVSLSVVKN*" /label="yrpD CDS" gene 2363810..2364517 /gene="yrpD" /locus_tag="BSU_26820" /old_locus_tag="BSU26820" /label="yrpD gene" downshifts 2364517 /Source="Nicolas_upshifts" /id="D1371" /incds=0 /nref=4 /ntot=168 /MaxReadThrough="5.98921" /MaxDrop="2.677" /score="15.7112026" /energy="-8.2" /TU="U2062" /idTUdmin="U2064" /TUdmin="-660" /isTUend="FALSE" /label="downshifts" S_feature 2364562..2364735 /Source="Nicolas_S_feature" /locus_tag="new_2740238_2740411" /HighExp="Lbstat, M0t90, M40t90, BT, S0, ferm, S2, M9-stat, Lbtran, T1.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="SigA" /TUlongPSig=1 /label="S1007" promotor_-35 2364717..2364718 /Source="Nicolas_upshift_promotors" /id="U2064" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.591408591408591" /psig="0.861138861138861" /xcortree=1974 /SigmaFactorBS="ccccttctgaacctgttccatttgctcaacgcaaaaggtgTG catcactgtcttaaaAATGTTAAAACAAATAGCAGatggtgcactttatttttagatg a" /listShort="S1008, S1009" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2364734..2364753 /Source="Nicolas_upshift_promotors" /id="U2064" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.591408591408591" /psig="0.861138861138861" /xcortree=1974 /SigmaFactorBS="ccccttctgaacctgttccatttgctcaacgcaaaaggtgTG catcactgtcttaaaAATGTTAAAACAAATAGCAGatggtgcactttatttttagatg a" /listShort="S1008, S1009" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2364737..2365065 /Source="Nicolas_S_feature" /locus_tag="new_2740413_2740741" /HighExp="Lbstat, M0t90, BT, M40t90, S2, S0, ferm, T2.0H, M9-stat, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99711000000000005" /TUshortSig="SigA, SigA" /TUshortPSig="0.861, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1008" upshifts 2364737 /Source="Nicolas_upshifts" /id="U2064" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.591408591408591" /psig="0.861138861138861" /xcortree=1974 /SigmaFactorBS="ccccttctgaacctgttccatttgctcaacgcaaaaggtgTG catcactgtcttaaaAATGTTAAAACAAATAGCAGatggtgcactttatttttagatg a" /listShort="S1008, S1009" /GFF_Attribute="listLong" /label="upshifts" CDS 2364841..2365002 /locus_tag="BSU_26829" /old_locus_tag="BSU26829" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:SOX90581.1" /translation="MYFHKRGMASYSSIASGRLANDWPRTTHHFETDSFQNHKYDPIT NKDQLAVQP*" /label="hypothetical protein CDS" gene 2364841..2365002 /locus_tag="BSU_26829" /old_locus_tag="BSU26829" /pseudo /label="gene" promotor_-35 2365031..2365040 /Source="Nicolas_upshift_promotors" /id="U2065" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1413 /SigmaFactorBS="atttttacatcaattaaactagcaTCACTATCGAataagctc gatcTGCATATCATGTACTATCCTcttttaaggaaggtgatgttatgaggtcatttcc a" /listShort="S1009, S1010" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2365053..2365072 /Source="Nicolas_upshift_promotors" /id="U2065" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1413 /SigmaFactorBS="atttttacatcaattaaactagcaTCACTATCGAataagctc gatcTGCATATCATGTACTATCCTcttttaaggaaggtgatgttatgaggtcatttcc a" /listShort="S1009, S1010" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2365067..2365218 /Source="Nicolas_S_feature" /locus_tag="new_2740743_2740894" /HighExp="BT, S8, B36, S7, Lbstat, G/S, Pyr, M0t90, B60, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.94474599999999997" /TUshortSig="SigK, SigA, SigA" /TUshortPSig="1, 0.861, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1009" upshifts 2365067 /Source="Nicolas_upshifts" /id="U2065" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1413 /SigmaFactorBS="atttttacatcaattaaactagcaTCACTATCGAataagctc gatcTGCATATCATGTACTATCCTcttttaaggaaggtgatgttatgaggtcatttcc a" /listShort="S1009, S1010" /GFF_Attribute="listLong" /label="upshifts" CDS 2365093..2365170 /gene="yrpDX" /locus_tag="BSU_26826" /old_locus_tag="BSU26826" /experiment="publication(s) with functional evidences, PMID:20709900" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20709900" /codon_start=1 /transl_table=11 /product="expressed polypeptide of unknown function" /protein_id="YP_009513985.1" /db_xref="EnsemblGenomes-Gn:BSU26826" /db_xref="EnsemblGenomes-Tr:CCQ48602" /db_xref="GOA:L8E9J8" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/TrEMBL:L8E9J8" /translation="MRSFPLIVVLFILLIIVGTSFFGGY*" /label="yrpDX CDS" gene 2365093..2365170 /gene="yrpDX" /locus_tag="BSU_26826" /old_locus_tag="BSU26826" /label="yrpDX gene" downshifts 2365175 /Source="Nicolas_upshifts" /id="D1372" /incds=0 /nref=23 /ntot=198 /MaxReadThrough="3.86249" /MaxDrop="4.0885" /score="28.4802594" /energy="-18.1" /TU="U2062,U2065" /idTUdmin="U2064" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" S_feature 2365220..2365417 /Source="Nicolas_S_feature" /locus_tag="new_2740896_2741093" /HighExp="BT, B36, S8, Lbstat, G/S, Pyr, Diami, S7, dia15, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA" /TUshortPSig="1, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1010" S_feature complement(2365409..2365680) /Source="Nicolas_S_feature" /locus_tag="new_2741085_2741356_c" /HighExp="Heat, BMM, Etha, S2, S3, S4, B36, S5, B60, T0.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.40965600000000002" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1011" downshifts complement(2365451) /Source="Nicolas_upshifts" /id="D1373" /incds=0 /nref=37 /ntot=78 /MaxReadThrough="2.30607" /MaxDrop="6.9537" /score="19.9821634" /energy="-15.5" /TU="NA" /idTUdmin="U2066" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2365457..2365618) /locus_tag="BSU_26827" /old_locus_tag="BSU26827" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513986.1" /translation="MGKKLIETIQYPPYYCDVAYLESSHMKSRRNLFQNKKSLDVWQW ITLEIYWLI*" /label="hypothetical protein CDS" gene complement(2365457..2365618) /locus_tag="BSU_26827" /old_locus_tag="BSU26827" /label="gene" CDS complement(2365681..2366436) /gene="zinT" /locus_tag="BSU_26830" /old_locus_tag="BSU26830" /function="16.14: Store" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12904577, 24128931; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="lipoprotein buffering protein for Zn2+ transport" /protein_id="NP_390560.1" /db_xref="EnsemblGenomes-Gn:BSU26830" /db_xref="EnsemblGenomes-Tr:CAB14624" /db_xref="GOA:O05410" /db_xref="InterPro:IPR012674" /db_xref="InterPro:IPR015304" /db_xref="SubtiList:BG12308" /db_xref="UniProtKB/Swiss-Prot:O05410" /translation="MNILFSKRLGILTIGSLLVLAGCQTSGSSAGESNQTTSSSAVEE DSSKTQEQTSDSHTHEHSHDHSHAHDEETEKIYEGYFKNSQVKDRLLSDWEGDWQSVY PYLQDGTLDEVFSYKSEHEGGKTAEEYKEYYKKGYQTDVDRIVIQKDTVTFFKNGKEY SGKYTYDGYEILTYDAGNRGVRYIFKLAKKAEGLPQYIQFSDHSIYPTKASHYHLYWG DDREALLDEVKNWPTYYPSKMDGHDIAHEMMAH*" /label="zinT CDS" gene complement(2365681..2366436) /gene="zinT" /locus_tag="BSU_26830" /old_locus_tag="BSU26830" /label="zinT gene" promotor_-10 complement(2366467..2366486) /Source="Nicolas_upshift_promotors" /id="U2066" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.54045954045954" /psig=1 /xcortree=666 /SigmaFactorBS="tttaaaataggccatccgcatgaagagcatttttccTTTGAT gtttgcaagagatgtATGTATAATAAATCGTAATGttttcgatttaataaaaaaggag t" /listShort="yrpE, S1011" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2366483) /Source="Nicolas_upshifts" /id="U2066" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.54045954045954" /psig=1 /xcortree=666 /SigmaFactorBS="tttaaaataggccatccgcatgaagagcatttttccTTTGAT gtttgcaagagatgtATGTATAATAAATCGTAATGttttcgatttaataaaaaaggag t" /listShort="yrpE, S1011" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2366502..2366507) /Source="Nicolas_upshift_promotors" /id="U2066" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.54045954045954" /psig=1 /xcortree=666 /SigmaFactorBS="tttaaaataggccatccgcatgaagagcatttttccTTTGAT gtttgcaagagatgtATGTATAATAAATCGTAATGttttcgatttaataaaaaaggag t" /listShort="yrpE, S1011" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2366568..2367098) /gene="sigZ" /locus_tag="BSU_26840" /old_locus_tag="BSU26840" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11700344, 15019740, 17675383" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11700344, 15019740, 17675383; Product type r: regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase ECF(extracytoplasmic function)-type sigma factor (sigma-Z)" /protein_id="NP_390561.1" /db_xref="EnsemblGenomes-Gn:BSU26840" /db_xref="EnsemblGenomes-Tr:CAB14625" /db_xref="GOA:O05409" /db_xref="InterPro:IPR000838" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR014304" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11976" /db_xref="UniProtKB/Swiss-Prot:O05409" /translation="MNIEDLWDQFHQPLKTYISHRVNDQSIVDDLLQIVFMKIQVHLP NLIDEQKIDSWIYRITRNTIIDFYRTKKTSEILPDVLHFNDSAEEENFTKEATVCIRS TIKRLPEKYREALELTDFQGLSQKELSEKLGISYSGAKSRVQRGRGKLKQLLEGCCHI EADRYGNIVDFRILKE*" /label="sigZ CDS" gene complement(2366568..2367098) /gene="sigZ" /locus_tag="BSU_26840" /old_locus_tag="BSU26840" /label="sigZ gene" promotor_-10 complement(2367144..2367163) /Source="Nicolas_upshift_promotors" /id="U2067" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.519480519480519" /psig="0.996003996003996" /xcortree=1905 /SigmaFactorBS="acctctcctttatcattatttttggcaacagctgcaatacaa tTGATTCAAcaattgtttgctcTTTGTTACGATTAAAAAGACgaagcaaatgtaaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2367167) /Source="Nicolas_upshifts" /id="U2067" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.519480519480519" /psig="0.996003996003996" /xcortree=1905 /SigmaFactorBS="acctctcctttatcattatttttggcaacagctgcaatacaa tTGATTCAAcaattgtttgctcTTTGTTACGATTAAAAAGACgaagcaaatgtaaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2367177..2367184) /Source="Nicolas_upshift_promotors" /id="U2067" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.519480519480519" /psig="0.996003996003996" /xcortree=1905 /SigmaFactorBS="acctctcctttatcattatttttggcaacagctgcaatacaa tTGATTCAAcaattgtttgctcTTTGTTACGATTAAAAAGACgaagcaaatgtaaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2367233..2368213 /gene="yrpG" /locus_tag="BSU_26850" /old_locus_tag="BSU26850" /EC_number="1.1.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23990306, 25326299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aldo-keto reductase" /protein_id="NP_390562.2" /db_xref="EnsemblGenomes-Gn:BSU26850" /db_xref="EnsemblGenomes-Tr:CAB14626" /db_xref="GOA:O05408" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="SubtiList:BG12309" /db_xref="UniProtKB/Swiss-Prot:O05408" /translation="MEYTYLGRTGLRVSRLCLGTMNFGVDTDEKTAFRIMDEALDNGI QFFDTANIYGWGKNAGLTESIIGKWFAQGGQRREKVVLATKVYEPISDPNDGPNDMRG LSLYKIRRHLEGSLKRLQTDHIELYQMHHIDRRTPWDEIWEAFETQVRSGKVDYIGSS NFAGWHLVKAQAEAEKRRFMGLVTEQHKYSLLERTAEMEVLPAARDLGLGVVAWSPLA GGLLGGKALKSNAGTRTAKRADLIEKHRLQLEKFSDLCKELGEKEANVALAWVLANPV LTAPIIGPRTVEQLRDTIKAVEISLDKEILRMLNDIFPGPGGETPEAYAW*" /label="yrpG CDS" gene 2367233..2368213 /gene="yrpG" /locus_tag="BSU_26850" /old_locus_tag="BSU26850" /label="yrpG gene" CDS complement(2368487..2369803) /gene="yraO" /locus_tag="BSU_26860" /old_locus_tag="BSU26860" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11053381, 11566984, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative citrate transporter" /protein_id="NP_390563.1" /db_xref="EnsemblGenomes-Gn:BSU26860" /db_xref="EnsemblGenomes-Tr:CAB14627" /db_xref="GOA:O05407" /db_xref="InterPro:IPR004680" /db_xref="InterPro:IPR014738" /db_xref="SubtiList:BG12279" /db_xref="UniProtKB/Swiss-Prot:O05407" /translation="MLTILGFSMVTVFTILIMTKKVSPIVALTITPIVFALIGGFGKG IGDMILEGIQTVASSAALLLFAILFFGILIDAGLFDPLIEKILSIVKGDPVKIAIGSA VLAMLIALDGDGTTTYMITVSAMLPLYKRIGMNPMVMATLAMLSLSIVSGMTPWGGPA TRAISVLGLDPSDFFVPLLPTMLGGIACVIFLAFLMGRKERNRIGIVQLEPRHITKDS SQSYMAATLESEQLKRPRLIYLNLFLVISIMVFIVLGTKHPSVLFLIGFVLALTINYP NVKMQKERIAEHSGNAITVVLLVFSAGVFAGILSGTKMVDAIAGSLISIIPSSMGGFF PVIVALTSIPFTFVLSNDAYYFGMVPIFAEAASAYGIEPVEIARASIMGQPVHLMSPL VASTVLLVSMLKMDLGSFQRFAVKWAVITSLVITLLAIITGAITIL*" /label="yraO CDS" gene complement(2368487..2369803) /gene="yraO" /locus_tag="BSU_26860" /old_locus_tag="BSU26860" /label="yraO gene" S_feature complement(2369804..2369917) /Source="Nicolas_S_feature" /locus_tag="new_2745480_2745593_c" /HighExp="Lbtran, M40t90, Lbstat, HiTm, Mal, Gly, M0t90, S1, T1.0H, Fru" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1012" CDS complement(2369918..2370787) /gene="yraN" /locus_tag="BSU_26870" /old_locus_tag="BSU26870" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20011599; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (probes citrate or citrate-related metabolite)" /protein_id="NP_390564.1" /db_xref="EnsemblGenomes-Gn:BSU26870" /db_xref="EnsemblGenomes-Tr:CAB14628" /db_xref="GOA:O07906" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12278" /db_xref="UniProtKB/Swiss-Prot:O07906" /translation="MDEKDWILLKILHEEQSVTKTAERLFTSQPSITYRLKKIEEIFG IELFTKRHKGITFTAEGEHLVAYARRMLQELQDTKDHISNLSKEVQGHLRLGVSSNFA QYKLPKLLREFSTMYPNVQYSVQTGWSTDVMKLLDAGIVQVGILRGSHRWKGVEERLT REKLHIISKKPITIEQLPFLPFIKYKTDASLKTIIEDWMHTNLKQAPIIAMEVDRQET CKEMVKHGLGYSIAPEICLQESDHLYTMELYNAKGKPLMRDTWLMYDQKSLGIKLVKA FIDFLKGEQMVTI*" /label="yraN CDS" gene complement(2369918..2370787) /gene="yraN" /locus_tag="BSU_26870" /old_locus_tag="BSU26870" /label="yraN gene" promotor_-10 complement(2370810..2370829) /Source="Nicolas_upshift_promotors" /id="U2068" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.318681318681319" /psig="0.998001998001998" /xcortree=3210 /SigmaFactorBS="gtgtagaaggtaaaaaaataaaaataaaatataagtttTCTT AAtattcgataaaaaaACTTTTATAATTGTGAAAGAaggactagaaaggaagatgaaa a" /listShort="yraN, S1012, yraO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2370827) /Source="Nicolas_upshifts" /id="U2068" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.318681318681319" /psig="0.998001998001998" /xcortree=3210 /SigmaFactorBS="gtgtagaaggtaaaaaaataaaaataaaatataagtttTCTT AAtattcgataaaaaaACTTTTATAATTGTGAAAGAaggactagaaaggaagatgaaa a" /listShort="yraN, S1012, yraO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2370844..2370849) /Source="Nicolas_upshift_promotors" /id="U2068" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.318681318681319" /psig="0.998001998001998" /xcortree=3210 /SigmaFactorBS="gtgtagaaggtaaaaaaataaaaataaaatataagtttTCTT AAtattcgataaaaaaACTTTTATAATTGTGAAAGAaggactagaaaggaagatgaaa a" /listShort="yraN, S1012, yraO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2370894..2370895) /Source="Nicolas_upshift_promotors" /id="U2069" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.367632367632368" /psig="0.537462537462537" /xcortree=645 /SigmaFactorBS="ctctcatgattgttacattcgtcttgaccATcgtcatcatcc tcatcttaaAGGTAGTATTTtttatGTtttttagtgtagaaggtaaaaaaataaaaat a" /listShort="yraN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2370902) /Source="Nicolas_upshifts" /id="U2069" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.367632367632368" /psig="0.537462537462537" /xcortree=645 /SigmaFactorBS="ctctcatgattgttacattcgtcttgaccATcgtcatcatcc tcatcttaaAGGTAGTATTTtttatGTtttttagtgtagaaggtaaaaaaataaaaat a" /listShort="yraN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2370932..2370933) /Source="Nicolas_upshift_promotors" /id="U2069" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.367632367632368" /psig="0.537462537462537" /xcortree=645 /SigmaFactorBS="ctctcatgattgttacattcgtcttgaccATcgtcatcatcc tcatcttaaAGGTAGTATTTtttatGTtttttagtgtagaaggtaaaaaaataaaaat a" /listShort="yraN" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2370932..2372035 /gene="prpF" /locus_tag="BSU_26880" /old_locus_tag="BSU26880" /EC_number="5.3.3.7" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 11294638, 12473114, 14702315, 17567742; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aconitate isomerase" /protein_id="NP_390565.2" /db_xref="EnsemblGenomes-Gn:BSU26880" /db_xref="EnsemblGenomes-Tr:CAB14629" /db_xref="GOA:O07931" /db_xref="InterPro:IPR007400" /db_xref="SubtiList:BG12277" /db_xref="UniProtKB/Swiss-Prot:O07931" /translation="MVKTNVTIMRGGTSKGVFFHESAMPNNKNEWEPFLLDVMGSPDK RQIDGLGGGNSLTSKVAIIKKAYTSDIDVHYTFGQVSISEEKVDFKGNCGNISAAVGP FAIEEGLVKAKEPMTAVRILNTNTNKMIIAEVEVEDGQVKYDGDVTISGVPGSGSPIY LNFHDAAGSVTGHLLPTGNSSEFLDTSQGQIEVSIIDYANPLVFVEASSIGLDGTELA EEFTDLQLAQFEELRSIAAEKCGFASRFSATKLSPAVPKLAIVAKPEKYKDSTGAWHS SVEMDLHIRMMSMQKPHQALAVTGAICTTRALSVEGAIPARIAKNHSTKVRLAHSSGI IETMVEPTGIKIVRTARRIMDGTVYTHGDYQMM*" /label="prpF CDS" gene 2370932..2372035 /gene="prpF" /locus_tag="BSU_26880" /old_locus_tag="BSU26880" /label="prpF gene" misc_feature 2371925..2371944 /Source="Nicolas_upshift_promotors" /id="U2070" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.736263736263736" /psig="0.984015984015984" /xcortree=3092 /SigmaFactorBS="atccctgcaagaatagcaaaaaaccactctacaaaggttcgg ctagctcattctTCTGGTATTATTGAAACAATggtggagcccactggtataaagatcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2371931 /Source="Nicolas_upshifts" /id="U2070" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.736263736263736" /psig="0.984015984015984" /xcortree=3092 /SigmaFactorBS="atccctgcaagaatagcaaaaaaccactctacaaaggttcgg ctagctcattctTCTGGTATTATTGAAACAATggtggagcccactggtataaagatcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(2372282) /Source="Nicolas_upshifts" /id="D1374" /incds=0 /nref=123 /ntot=254 /MaxReadThrough="2.33762" /MaxDrop="7.47213" /score="6.31571576" /energy="-8.7" /TU="U2071" /idTUdmin="U2071" /TUdmin="-33" /isTUend="FALSE" /label="downshifts" CDS complement(2372308..2373141) /gene="csn" /locus_tag="BSU_26890" /old_locus_tag="BSU26890" /EC_number="3.2.1.132" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11065371, 11320136, 1664582, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11065371, 11320136, 1664582, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="chitosanase" /protein_id="NP_390566.1" /db_xref="EnsemblGenomes-Gn:BSU26890" /db_xref="EnsemblGenomes-Tr:CAB14630" /db_xref="GOA:O07921" /db_xref="InterPro:IPR000400" /db_xref="InterPro:IPR023346" /db_xref="SubtiList:BG11923" /db_xref="UniProtKB/Swiss-Prot:O07921" /translation="MKISMQKADFWKKAAISLLVFTMFFTLMMSETVFAAGLNKDQKR RAEQLTSIFENGTTEIQYGYVERLDDGRGYTCGRAGFTTATGDALEVVEVYTKAVPNN KLKKYLPELRRLAKEESDDTSNLKGFASAWKSLANDKEFRAAQDKVNDHLYYQPAMKR SDNAGLKTALARAVMYDTVIQHGDGDDPDSFYALIKRTNKKAGGSPKDGIDEKKWLNK FLDVRYDDLMNPANHDTRDEWRESVARVDVLRSIAKENNYNLNGPIHVRSNEYGNFVI K*" /label="csn CDS" gene complement(2372308..2373141) /gene="csn" /locus_tag="BSU_26890" /old_locus_tag="BSU26890" /label="csn gene" misc_feature complement(2373171..2373190) /Source="Nicolas_upshift_promotors" /id="U2071" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.84015984015984" /psig="0.992007992007992" /xcortree=504 /SigmaFactorBS="agattcaaaatattgacaaattgatgtattttcaacaatagg gcagtttcTTCATGTATACTGAGTCTGTatttacaatatttagaaaggggaagtgaaa t" /listShort="csn" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2373180) /Source="Nicolas_upshifts" /id="U2071" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.84015984015984" /psig="0.992007992007992" /xcortree=504 /SigmaFactorBS="agattcaaaatattgacaaattgatgtattttcaacaatagg gcagtttcTTCATGTATACTGAGTCTGTatttacaatatttagaaaggggaagtgaaa t" /listShort="csn" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2373346..2373350 /Source="Nicolas_upshift_promotors" /id="U2072" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.450549450549451" /psig="0.992007992007992" /xcortree=490 /SigmaFactorBS="gggaaggtcccttgattttcatactgcttcaactttcattaa caaGATGCcataaggctttactCTATTTTATAATGGAAGTGAtcatcgaaaatcgtta g" /listShort="S1013, yraL" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2373361..2373583 /Source="Nicolas_S_feature" /locus_tag="new_2749037_2749259" /HighExp="Lbstat, M9-stat, B60, M0t90, M40t90, T1.30H, T2.0H, T3.0H, T2.30H, T1.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.97565800000000003" /TUshortSig="SigA" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S1013" upshifts 2373361 /Source="Nicolas_upshifts" /id="U2072" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.450549450549451" /psig="0.992007992007992" /xcortree=490 /SigmaFactorBS="gggaaggtcccttgattttcatactgcttcaactttcattaa caaGATGCcataaggctttactCTATTTTATAATGGAAGTGAtcatcgaaaatcgtta g" /listShort="S1013, yraL" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2373365..2373384 /Source="Nicolas_upshift_promotors" /id="U2072" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.450549450549451" /psig="0.992007992007992" /xcortree=490 /SigmaFactorBS="gggaaggtcccttgattttcatactgcttcaactttcattaa caaGATGCcataaggctttactCTATTTTATAATGGAAGTGAtcatcgaaaatcgtta g" /listShort="S1013, yraL" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2373584..2373847 /gene="yraL" /locus_tag="BSU_26900" /old_locus_tag="BSU26900" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390567.1" /db_xref="EnsemblGenomes-Gn:BSU26900" /db_xref="EnsemblGenomes-Tr:CAB14631" /db_xref="GOA:O07917" /db_xref="InterPro:IPR009057" /db_xref="SubtiList:BG12276" /db_xref="UniProtKB/Swiss-Prot:O07917" /translation="MAYVKATAILPEKLISEIQKYVQGKTIYIPKPESSHQKWGACSG TRKLIDDRNASIKKAFKNGKTIHQLSDEYHLSIETIKKIVYSK*" /label="yraL CDS" gene 2373584..2373847 /gene="yraL" /locus_tag="BSU_26900" /old_locus_tag="BSU26900" /label="yraL gene" downshifts 2373835 /Source="Nicolas_upshifts" /id="D1375" /incds=0 /nref=71 /ntot=223 /MaxReadThrough="1.7419" /MaxDrop="4.94534" /score="-1.04752822" /energy="-9.9" /TU="NA" /idTUdmin="U2072" /TUdmin="-10" /isTUend="TRUE" /label="downshifts" CDS 2373984..2374799 /gene="yraK" /locus_tag="BSU_26910" /old_locus_tag="BSU26910" /function="18.1: Enzymes of unknown specificity" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390568.2" /db_xref="EnsemblGenomes-Gn:BSU26910" /db_xref="EnsemblGenomes-Tr:CAB14632" /db_xref="GOA:O07937" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12275" /db_xref="UniProtKB/Swiss-Prot:O07937" /translation="MTINNGTLQVPGANIHYQVRGSGPIILLVHGGGGDADKFHHVAN HLANWYTVVTYDRRGHSRSNLANQIEGYRVETHSDDAHRLLAKITNKPAYVFGSSSGA VIGLDLCIRHPEQVHVMIPHEPILLQLLHGNELKQAEQFMEDLKKNHRSEVIKLMSRL ETDEQSKAVLTKRLLGNSTYFTEYEIQGILSYTLDFEALKTVFTSSPMKILPAGGSAS RELFPYRCANALAEQLETEWVEFPGNHTGYTMYHKEFSERLHDMLEKEKKHTC*" /label="yraK CDS" gene 2373984..2374799 /gene="yraK" /locus_tag="BSU_26910" /old_locus_tag="BSU26910" /label="yraK gene" S_feature complement(2375134..2375206) /Source="Nicolas_S_feature" /locus_tag="new_2750810_2750882_c" /HighExp="BC, Lbstat, Sw, M40t90, M0t90, S2, BI, BT, S3, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1014" downshifts complement(2375177) /Source="Nicolas_upshifts" /id="D1376" /incds=0 /nref=44 /ntot=205 /MaxReadThrough="1.43644" /MaxDrop="4.78753" /score="-0.984762906" /energy="-12.6" /TU="NA" /idTUdmin="U2073" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2375207..2375563) /gene="yraJ" /locus_tag="BSU_26920" /old_locus_tag="BSU26920" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390569.2" /db_xref="EnsemblGenomes-Gn:BSU26920" /db_xref="EnsemblGenomes-Tr:CAB14633" /db_xref="InterPro:IPR003646" /db_xref="SubtiList:BG12274" /db_xref="UniProtKB/Swiss-Prot:O07934" /translation="MTKLKMLSMLTVMIASLFIFSSQALAVQYFTVSTSSGAPVNMRS GPGTNYPIMLSIPSGSRVPYYCYAYGTTVTGKYGTSNIWDQIQWKDSRGVVNIGYVSD TYVYTGSDGPVGYKCN*" /label="yraJ CDS" gene complement(2375207..2375563) /gene="yraJ" /locus_tag="BSU_26920" /old_locus_tag="BSU26920" /label="yraJ gene" CDS complement(2375616..2375975) /gene="yraI" /locus_tag="BSU_26930" /old_locus_tag="BSU26930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390570.2" /db_xref="EnsemblGenomes-Gn:BSU26930" /db_xref="EnsemblGenomes-Tr:CAB14634" /db_xref="InterPro:IPR003646" /db_xref="SubtiList:BG12273" /db_xref="UniProtKB/Swiss-Prot:O07909" /translation="MNKLKRLSMLTVMIASVFIFSSHALAAQYYTVSTSSGAPVNMRS GPGTSWGIVTTIPSGTRIPIYCYKTGTTVTGKYGTSNIWNYTERTLASGEIVPGFVSD TYMYTGSDGPVVPKCSW*" /label="yraI CDS" gene complement(2375616..2375975) /gene="yraI" /locus_tag="BSU_26930" /old_locus_tag="BSU26930" /label="yraI gene" misc_feature complement(2376068..2376087) /Source="Nicolas_upshift_promotors" /id="U2073" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.487512487512487" /psig="0.99100899100899" /xcortree=492 /SigmaFactorBS="tccttaattgtcgaaaacataggaataattccacttttgaaa gatctagttTATGGTACATTGATAAATATatgggaggggagggggcatggtatctgaa a" /listShort="yraI, yraJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2376078) /Source="Nicolas_upshifts" /id="U2073" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.487512487512487" /psig="0.99100899100899" /xcortree=492 /SigmaFactorBS="tccttaattgtcgaaaacataggaataattccacttttgaaa gatctagttTATGGTACATTGATAAATATatgggaggggagggggcatggtatctgaa a" /listShort="yraI, yraJ" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2376247..2376348) /locus_tag="BSU_26935" /old_locus_tag="BSU26935" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513987.1" /translation="MIGEKGGVSMNREEAWIQGSSTLIELIGGNEAA*" /label="hypothetical protein CDS" gene complement(2376247..2376348) /locus_tag="BSU_26935" /old_locus_tag="BSU26935" /label="gene" S_feature complement(2376388..2376490) /Source="Nicolas_S_feature" /locus_tag="new_2752064_2752166_c" /HighExp="M40t90, LBGstat, M40t45, M0t90, Lbstat, Lbtran, LBGtran, LPhT, ferm, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.575" /TUlongSig="NA" /TUlongPSig="NA" /label="S1015" downshifts complement(2376430) /Source="Nicolas_upshifts" /id="D1377" /incds=0 /nref=19 /ntot=188 /MaxReadThrough="2.12056" /MaxDrop="4.09264" /score="-0.984762906" /energy="-12.6" /TU="NA" /idTUdmin="U2074" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2376491..2376877) /gene="yraH" /locus_tag="BSU_26940" /old_locus_tag="BSU26940" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lyase" /protein_id="NP_390571.1" /db_xref="EnsemblGenomes-Gn:BSU26940" /db_xref="EnsemblGenomes-Tr:CAB14635" /db_xref="GOA:O07918" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR018146" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG12272" /db_xref="UniProtKB/Swiss-Prot:O07918" /translation="MKLLQIRLLVNDFKKSVEFYKDSLGLPISWLENEMEYALFDNGE TKIELLSRETMAEIVGEEKKSLEGEAQSKFLLQFKVEDVDKTYDDLHEKGVKCENKPH DRKEWSARVAHFRDPDHNLIEIYKML*" /label="yraH CDS" gene complement(2376491..2376877) /gene="yraH" /locus_tag="BSU_26940" /old_locus_tag="BSU26940" /label="yraH gene" misc_feature complement(2376919..2376935) /Source="Nicolas_upshift_promotors" /id="U2074" /multdbtbs="-" /comp="M18" /sig="SigA" /pcomp="0.245754245754246" /psig="0.575424575424575" /xcortree=1510 /SigmaFactorBS="tgcacttaaatctgaaataagggtgaagtatggaaacttgac atagtgctgtcaggtttcTTTGGTATCATTAAATTggatgaccagtaaaagtatggtt t" /listShort="yraH, S1015" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2376935) /Source="Nicolas_upshifts" /id="U2074" /multdbtbs="-" /comp="M18" /sig="SigA" /pcomp="0.245754245754246" /psig="0.575424575424575" /xcortree=1510 /SigmaFactorBS="tgcacttaaatctgaaataagggtgaagtatggaaacttgac atagtgctgtcaggtttcTTTGGTATCATTAAATTggatgaccagtaaaagtatggtt t" /listShort="yraH, S1015" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2377068..2377074 /Source="Nicolas_upshift_promotors" /id="U2075" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=887 /SigmaFactorBS="gcgattcttaaaacaaaaaatgataccgagtgtattttcTGT ATGCttcaacttcatttcGGGAAATGTAACgttgataaaaggaggttacatcaatatg g" /listShort="yraG, yraF, adhB, yraE, yraD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2377089..2377100 /Source="Nicolas_upshift_promotors" /id="U2075" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=887 /SigmaFactorBS="gcgattcttaaaacaaaaaatgataccgagtgtattttcTGT ATGCttcaacttcatttcGGGAAATGTAACgttgataaaaggaggttacatcaatatg g" /listShort="yraG, yraF, adhB, yraE, yraD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2377089 /Source="Nicolas_upshifts" /id="U2075" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=887 /SigmaFactorBS="gcgattcttaaaacaaaaaatgataccgagtgtattttcTGT ATGCttcaacttcatttcGGGAAATGTAACgttgataaaaggaggttacatcaatatg g" /listShort="yraG, yraF, adhB, yraE, yraD" /GFF_Attribute="listLong" /label="upshifts" CDS 2377126..2377371 /gene="yraG" /locus_tag="BSU_26950" /old_locus_tag="BSU26950" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10066829, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_390572.1" /db_xref="EnsemblGenomes-Gn:BSU26950" /db_xref="EnsemblGenomes-Tr:CAB14636" /db_xref="GOA:O07919" /db_xref="InterPro:IPR012347" /db_xref="SubtiList:BG12271" /db_xref="UniProtKB/Swiss-Prot:O07919" /translation="MDHQTLAAHEAVDLHEIVNFKTLCIAKSKLMQGLVFDQELKDLM EKDVQQSIQDLTELQAVYERASFQAPVPQSRPTPIIN*" /label="yraG CDS" gene 2377126..2377371 /gene="yraG" /locus_tag="BSU_26950" /old_locus_tag="BSU26950" /label="yraG gene" CDS 2377389..2377757 /gene="yraF" /locus_tag="BSU_26960" /old_locus_tag="BSU26960" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10066829, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_390573.1" /db_xref="EnsemblGenomes-Gn:BSU26960" /db_xref="EnsemblGenomes-Tr:CAB14637" /db_xref="GOA:O07949" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR012851" /db_xref="SubtiList:BG12270" /db_xref="UniProtKB/Swiss-Prot:O07949" /translation="MNNDHLDPINSLNVPELADTTFAMDFLIRAKEGVRNTAVALTET ASPDVRALLRKQLMQGIAMHQEITELMISKKWFHPYELSEQYKLDQLSAKNTIMVGNM NLFPDETNRKGMFDRTPDEH*" /label="yraF CDS" gene 2377389..2377757 /gene="yraF" /locus_tag="BSU_26960" /old_locus_tag="BSU26960" /label="yraF gene" CDS 2377776..2378912 /gene="adhB" /locus_tag="BSU_26970" /old_locus_tag="BSU26970" /EC_number="1.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7926692, 17586670; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase (involving bacillithiol)" /protein_id="NP_390574.2" /db_xref="EnsemblGenomes-Gn:BSU26970" /db_xref="EnsemblGenomes-Tr:CAB14638" /db_xref="GOA:O06012" /db_xref="InterPro:IPR002328" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR027399" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11902" /db_xref="UniProtKB/Swiss-Prot:O06012" /translation="MKAVTYQGIKNVVVKDVPDPKIEKSDDMIIKVTSTAICGSDLHL IHGFIPNMQEDYVIGHEPMGIVEEVGSGVTKLKKGDRVIIPFNIACGECFFCKNQLES QCDQSNDNGEMGAYFGYSGQTGGYPGGQAEYLRVPFANFTHFKIPESCEEPDEKLSVI ADAMTTGFWSVDNAGVKKGDTVIVLGCGPVGLFAQKFCWLKGAKRVIAVDYVNYRLQH AKRTNKVEIVNFEDHENTGNYLKEITKGGADVVIDAVGMDGKMSDLEFLASGLKLHGG TMSALVIASQAVRKGGTIQITGVYGGRYNGFPLGDIMQRNVNIRSGQAPVIHYMPYMF ELVSTGKIDPGDVVSHVLPLSEAKHGYDIFDSKMDDCIKVVLKP*" /label="adhB CDS" gene 2377776..2378912 /gene="adhB" /locus_tag="BSU_26970" /old_locus_tag="BSU26970" /label="adhB gene" CDS 2378931..2379128 /gene="yraE" /locus_tag="BSU_26980" /old_locus_tag="BSU26980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10066829, 22882546; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_390575.1" /db_xref="EnsemblGenomes-Gn:BSU26980" /db_xref="EnsemblGenomes-Tr:CAB14639" /db_xref="InterPro:IPR012347" /db_xref="SubtiList:BG13780" /db_xref="UniProtKB/Swiss-Prot:O06011" /translation="MEYALHEVLEVQEMTAFKTLCLTKSKTMKALVSDPKLKEIMQQD VDITTRQLQEFASILSNAKQE*" /label="yraE CDS" gene 2378931..2379128 /gene="yraE" /locus_tag="BSU_26980" /old_locus_tag="BSU26980" /label="yraE gene" CDS 2379144..2379443 /gene="yraD" /locus_tag="BSU_26990" /old_locus_tag="BSU26990" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10066829, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_390576.1" /db_xref="EnsemblGenomes-Gn:BSU26990" /db_xref="EnsemblGenomes-Tr:CAB14640" /db_xref="GOA:O06010" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR012851" /db_xref="SubtiList:BG13779" /db_xref="UniProtKB/Swiss-Prot:O06010" /translation="MNPIIEYLTGMNVLTDQIIAMDLLISAKNGVRNYAMAATEAGTP EVKEVLIRHLEEALDMHEQLSSYMMEKGWYHPWNPDEQVKLNLKNIDTAIQLPTL*" /label="yraD CDS" gene 2379144..2379443 /gene="yraD" /locus_tag="BSU_26990" /old_locus_tag="BSU26990" /label="yraD gene" downshifts 2379434 /Source="Nicolas_upshifts" /id="D1378" /incds=0 /nref=11 /ntot=39 /MaxReadThrough="1.62449" /MaxDrop="3.8153" /score="-8.57687054" /energy="-10.7" /TU="NA" /idTUdmin="U2075" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2379706..2380128) /gene="adhR" /locus_tag="BSU_27000" /old_locus_tag="BSU27000" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14663075, 17962296, 19170879" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14663075, 17962296, 19170879; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator regulated by thiol-alkylation" /protein_id="NP_390578.2" /db_xref="EnsemblGenomes-Gn:BSU27000" /db_xref="EnsemblGenomes-Tr:CAB14642" /db_xref="GOA:O06008" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="SubtiList:BG13777" /db_xref="UniProtKB/Swiss-Prot:O06008" /translation="MNIAQVAKQFGLTAATLRYYERVGLIPPVKRKDSGIRDYDEEDI KWIEFIKCMRNAGLSIEALIEYTTLFTEGDRTVEARKNILADERQRLIEKRKEIDETI KRLDTKIKDYDGKLRENEAKLKSRPKTESLHGSVEQRR*" /label="adhR CDS" gene complement(2379706..2380128) /gene="adhR" /locus_tag="BSU_27000" /old_locus_tag="BSU27000" /label="adhR gene" promotor_-35 2380126..2380129 /Source="Nicolas_upshift_promotors" /id="U2076" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.547452547452547" /psig="0.926073926073926" /xcortree=2007 /SigmaFactorBS="aactgctttgccacctgagcaatattCATGatcttcacctct ctaTCCTGTATGTTGTGAAGGTAacacttaaagttaactttaagtcaagctcaaaaca a" /listShort="S1016, yrzP, S1017, adhA" /listLong="yraA, S1018" /label="promotor_-35" promotor_-10 2380145..2380164 /Source="Nicolas_upshift_promotors" /id="U2076" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.547452547452547" /psig="0.926073926073926" /xcortree=2007 /SigmaFactorBS="aactgctttgccacctgagcaatattCATGatcttcacctct ctaTCCTGTATGTTGTGAAGGTAacacttaaagttaactttaagtcaagctcaaaaca a" /listShort="S1016, yrzP, S1017, adhA" /listLong="yraA, S1018" /label="promotor_-10" S_feature 2380160..2380310 /Source="Nicolas_S_feature" /locus_tag="new_2755836_2755986" /HighExp="Diami, dia15, dia5, H2O2, S8, Paraq, S5, G180, S6, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.926" /TUlongSig="NA" /TUlongPSig="NA" /label="S1016" upshifts 2380160 /Source="Nicolas_upshifts" /id="U2076" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.547452547452547" /psig="0.926073926073926" /xcortree=2007 /SigmaFactorBS="aactgctttgccacctgagcaatattCATGatcttcacctct ctaTCCTGTATGTTGTGAAGGTAacacttaaagttaactttaagtcaagctcaaaaca a" /listShort="S1016, yrzP, S1017, adhA" /listLong="yraA, S1018" /label="upshifts" promotor_-10 complement(2380163..2380182) /Source="Nicolas_upshift_promotors" /id="U2077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.984015984015984" /xcortree=2044 /SigmaFactorBS="tatataaacccagattcagcagctaacCACTTGTTttgagct tgacttAAAGTTAACTTTAAGTGTTAccttcacaacatacaggatagagaggtgaaga t" /listShort="yraB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2380170) /Source="Nicolas_upshifts" /id="U2077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.984015984015984" /xcortree=2044 /SigmaFactorBS="tatataaacccagattcagcagctaacCACTTGTTttgagct tgacttAAAGTTAACTTTAAGTGTTAccttcacaacatacaggatagagaggtgaaga t" /listShort="yraB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2380196..2380203) /Source="Nicolas_upshift_promotors" /id="U2077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.984015984015984" /xcortree=2044 /SigmaFactorBS="tatataaacccagattcagcagctaacCACTTGTTttgagct tgacttAAAGTTAACTTTAAGTGTTAccttcacaacatacaggatagagaggtgaaga t" /listShort="yraB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2380279..2380298) /Source="Nicolas_upshift_promotors" /id="U2078" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.975024975024975" /psig="0.99000999000999" /xcortree=630 /SigmaFactorBS="ctaattgttctcttccggcagtgtgttTATTTGCCattcagc aatccctCCAACTACACTGTTTTTAGTgcatggagaagtatagagtttaaagtgtgct t" /GFF_Attribute="listShort" /listLong="yraB" /label="promotor_-10" upshifts complement(2380287) /Source="Nicolas_upshifts" /id="U2078" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.975024975024975" /psig="0.99000999000999" /xcortree=630 /SigmaFactorBS="ctaattgttctcttccggcagtgtgttTATTTGCCattcagc aatccctCCAACTACACTGTTTTTAGTgcatggagaagtatagagtttaaagtgtgct t" /GFF_Attribute="listShort" /listLong="yraB" /label="upshifts" CDS 2380311..2380505 /gene="yrzP" /locus_tag="BSU_27009" /old_locus_tag="BSU27009" /EC_number="4.1.1.44" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17962296, 19170879; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative carboxymuconolactone decarboxylase" /protein_id="YP_009513988.1" /db_xref="EnsemblGenomes-Gn:BSU27009" /db_xref="EnsemblGenomes-Tr:CAX52671" /db_xref="InterPro:IPR029032" /db_xref="UniProtKB/TrEMBL:C0H460" /translation="MANKHTAGREQLGEFAPKFAELHDDVLFGDIWAREEELSSRDRS MITVSALITDCFSAYKSGSF*" /label="yrzP CDS" gene 2380311..2380505 /gene="yrzP" /locus_tag="BSU_27009" /old_locus_tag="BSU27009" /label="yrzP gene" promotor_-35 complement(2380313..2380320) /Source="Nicolas_upshift_promotors" /id="U2078" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.975024975024975" /psig="0.99000999000999" /xcortree=630 /SigmaFactorBS="ctaattgttctcttccggcagtgtgttTATTTGCCattcagc aatccctCCAACTACACTGTTTTTAGTgcatggagaagtatagagtttaaagtgtgct t" /GFF_Attribute="listShort" /listLong="yraB" /label="promotor_-35" promotor_-35 2380523..2380530 /Source="Nicolas_upshift_promotors" /id="U2079" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.987012987012987" /xcortree=2722 /SigmaFactorBS="atcaggttcattttaaatggtttttttaaaaaaCCCTTGCCt taaagcagactttaAGGTTTATCGTTATGTTGAAgacaccataaaacataaataagtg c" /listShort="S1017, adhA" /listLong="yraA" /label="promotor_-35" promotor_-10 2380546..2380565 /Source="Nicolas_upshift_promotors" /id="U2079" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.987012987012987" /xcortree=2722 /SigmaFactorBS="atcaggttcattttaaatggtttttttaaaaaaCCCTTGCCt taaagcagactttaAGGTTTATCGTTATGTTGAAgacaccataaaacataaataagtg c" /listShort="S1017, adhA" /listLong="yraA" /label="promotor_-10" upshifts 2380550 /Source="Nicolas_upshifts" /id="U2079" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.987012987012987" /xcortree=2722 /SigmaFactorBS="atcaggttcattttaaatggtttttttaaaaaaCCCTTGCCt taaagcagactttaAGGTTTATCGTTATGTTGAAgacaccataaaacataaataagtg c" /listShort="S1017, adhA" /listLong="yraA" /label="upshifts" S_feature 2380551..2380635 /Source="Nicolas_S_feature" /locus_tag="new_2756227_2756311" /HighExp="LBGstat, dia15, Diami, LPhT, LBGtran, dia5, M40t90, Lbtran, H2O2, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.987, 0.926" /TUlongSig="NA" /TUlongPSig="NA" /label="S1017" CDS 2380636..2381685 /gene="adhA" /locus_tag="BSU_27010" /old_locus_tag="BSU27010" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19170879; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aldehyde dehydrogenase; carbonyl stressresponse" /protein_id="NP_390579.2" /db_xref="EnsemblGenomes-Gn:BSU27010" /db_xref="EnsemblGenomes-Tr:CAB14643" /db_xref="GOA:C0SPA5" /db_xref="InterPro:IPR002328" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12562" /db_xref="UniProtKB/Swiss-Prot:C0SPA5" /translation="MCNQHQTRVLSVSHAKAKFEQTTIERRGLRPHDVLIDIKFSGIC HSDIHSAFDEWGGGIFPMVPGHEIAGVVTAVGTKVTKLAVGDRVGVGCFVDSCGECEY CLNAEEQFCTKGVVQTYNSVDYDGNPTYGGYSQKIVVTDRFVVRIPDRLEMDVASPLL CAGITTYSPLKHWNVGPGKKVAIVGVGGLGHLAIQFAHAMGAEVTVLSRSMNKKEEAL ELGANHYFATSDPATFTALAGRFDVILNTVSANLDVDAYLSMLRIDGTLVSVGAPAKP DTYSVFSLIMGRRSIAGSLVGGIQETQEMLDFAAEHGIEPKIEVIGADQVDEAYERIL RSDVRYRFVIDISTL*" /label="adhA CDS" gene 2380636..2381685 /gene="adhA" /locus_tag="BSU_27010" /old_locus_tag="BSU27010" /label="adhA gene" promotor_-35 2381753..2381760 /Source="Nicolas_upshift_promotors" /id="U2080" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2035 /SigmaFactorBS="cgaaaaatgatctctttaagcaaatATTTTGAAggccggtca atcttCCTGTTATTCTATGAATAGAgagttattaggagggttttttatgagcaaaaaa a" /listShort="yraA, S1018" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2381775..2381794 /Source="Nicolas_upshift_promotors" /id="U2080" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2035 /SigmaFactorBS="cgaaaaatgatctctttaagcaaatATTTTGAAggccggtca atcttCCTGTTATTCTATGAATAGAgagttattaggagggttttttatgagcaaaaaa a" /listShort="yraA, S1018" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2381788 /Source="Nicolas_upshifts" /id="U2080" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2035 /SigmaFactorBS="cgaaaaatgatctctttaagcaaatATTTTGAAggccggtca atcttCCTGTTATTCTATGAATAGAgagttattaggagggttttttatgagcaaaaaa a" /listShort="yraA, S1018" /GFF_Attribute="listLong" /label="upshifts" CDS 2381816..2382325 /gene="sufL" /locus_tag="BSU_27020" /old_locus_tag="BSU27020" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12775685, 17257049, 17933887, 24330391, 26774339; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="deglycase; general stress protecting enzyme; protects against methylglyoxal toxicity" /protein_id="NP_390580.2" /db_xref="EnsemblGenomes-Gn:BSU27020" /db_xref="EnsemblGenomes-Tr:CAB14644" /db_xref="GOA:O06006" /db_xref="InterPro:IPR002818" /db_xref="InterPro:IPR006286" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG13776" /db_xref="UniProtKB/Swiss-Prot:O06006" /translation="MSKKIAVLVTDQFEDIEYTSPVKAYEEAGYSVVAIDLEAGKEVT GKHGEKVKIDKAISDVDASDFDALLIPGGFSPDLLRADDRPGEFAKAFVENKKPVFAI CHGPQVLIDTDLLKGKDITGYRSIRKDLINAGANYKDAEVVVSHNIVTSRTPDDLEAF NRESLNLLK*" /label="sufL CDS" gene 2381816..2382325 /gene="sufL" /locus_tag="BSU_27020" /old_locus_tag="BSU27020" /label="sufL gene" downshifts 2382294 /Source="Nicolas_upshifts" /id="D1379" /incds=0 /nref=178 /ntot=254 /MaxReadThrough="4.08169" /MaxDrop="5.1444" /score="24.8267602" /energy="-16.3" /TU="U2080" /idTUdmin="U2076" /TUdmin=528 /isTUend="FALSE" /label="downshifts" S_feature 2382339..2383444 /Source="Nicolas_S_feature" /locus_tag="new_2758015_2759120" /HighExp="Diami, dia5, Etha, dia15, LPhT, H2O2, Lbstat, Salt, Fru, Paraq" /AntisenseName="sacC" /AntisenseCor="0.18236909579254801" /AntisenseRegPval="-2.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.926" /label="S1018" CDS complement(2382367..2384400) /gene="sacC" /locus_tag="BSU_27030" /old_locus_tag="BSU27030" /EC_number="3.2.1.7" /EC_number="3.2.1.65" /EC_number="3.2.1.80" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7646030, 8057358, 10217495, 12224641" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7646030, 8057358, 10217495, 12224641; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="levanase" /protein_id="NP_390581.1" /db_xref="EnsemblGenomes-Gn:BSU27030" /db_xref="EnsemblGenomes-Tr:CAB14645" /db_xref="GOA:P05656" /db_xref="InterPro:IPR001362" /db_xref="InterPro:IPR013148" /db_xref="InterPro:IPR013189" /db_xref="InterPro:IPR013320" /db_xref="InterPro:IPR018053" /db_xref="InterPro:IPR023296" /db_xref="PDB:4AZZ" /db_xref="PDB:4B1L" /db_xref="PDB:4B1M" /db_xref="SubtiList:BG10320" /db_xref="UniProtKB/Swiss-Prot:P05656" /translation="MKKRLIQVMIMFTLLLTMAFSADAADSSYYDEDYRPQYHFTPEA NWMNDPNGMVYYAGEYHLFYQYHPYGLQWGPMHWGHAVSKDLVTWEHLPVALYPDEKG TIFSGSAVVDKNNTSGFQTGKEKPLVAIYTQDREGHQVQSIAYSNDKGRTWTKYAGNP VIPNPGKKDFRDPKVFWYEKEKKWVMVLAAGDRILIYTSKNLKQWTYASEFGQDQGSH GGVWECPDLFELPVDGNPNQKKWVMQVSVGNGAVSGGSGMQYFVGDFDGTHFKNENPP NKVLWTDYGRDFYAAVSWSDIPSTDSRRLWLGWMSNWQYANDVPTSPWRSATSIPREL KLKAFTEGVRVVQTPVKELETIRGTSKKWKNLTISPASHNVLAGQSGDAYEINAEFKV SPGSAAEFGFKVRTGENQFTKVGYDRRNAKLFVDRSESGNDTFNPAFNTGKETAPLKP VNGKVKLRIFVDRSSVEVFGNDGKQVITDIILPDRSSKGLELYAANGGVKVKSLTIHP LKKVWGTTPFMSNMTGWTTVNGTWADTIEGKQGRSDGDSFILSSASGSDFTYESDITI KDGNGRGAGALMFRSDKDAKNGYLANVDAKHDLVKFFKFENGAASVIAEYKTPIDVNK KYHLKTEAEGDRFKIYLDDRLVIDAHDSVFSEGQFGLNVWDATAVFQNVTKES*" /label="sacC CDS" gene complement(2382367..2384400) /gene="sacC" /locus_tag="BSU_27030" /old_locus_tag="BSU27030" /label="sacC gene" downshifts complement(2382392) /Source="Nicolas_upshifts" /id="D1380" /incds=0 /nref=14 /ntot=60 /MaxReadThrough="0.56875" /MaxDrop="5.09923" /score="-2.07442916" /energy="-14.2" /TU="NA" /idTUdmin="U2081" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2384309..2384476) /locus_tag="BSU_27035" /old_locus_tag="BSU27035" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513989.1" /translation="MPETDQLAQQSLLKVFKHEERSEGTNEKETDSSHDHVHPAVDYG IFGRCSRFKLL*" /label="hypothetical protein CDS" gene complement(2384309..2384476) /locus_tag="BSU_27035" /old_locus_tag="BSU27035" /label="gene" S_feature complement(2384401..2384556) /Source="Nicolas_S_feature" /locus_tag="new_2760077_2760232_c" /HighExp="UNK1, Fru, B60, T0.30H, M40t90, M0t90, ferm, LPh, GM-0.2, GM-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigL" /TUshortPSig="0.886" /TUlongSig="NA" /TUlongPSig="NA" /label="S1019" CDS complement(2384557..2385384) /gene="levG" /locus_tag="BSU_27040" /old_locus_tag="BSU27040" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:2117666, 9033408, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2117666, 9033408, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) fructose-specific enzyme IID component" /protein_id="NP_390582.1" /db_xref="EnsemblGenomes-Gn:BSU27040" /db_xref="EnsemblGenomes-Tr:CAB14646" /db_xref="GOA:P26382" /db_xref="InterPro:IPR004704" /db_xref="SubtiList:BG10319" /db_xref="UniProtKB/Swiss-Prot:P26382" /translation="MEKEKRLTKKEIFSMFIRSNFLLGSFNFERVQAMGYCYVMIPAI KKLYGPGAKRNEALQRHLEWFNTHPWLTAPIFGVTAAMEEEMANNKGIDGKAISGMKI GLMGPIAGVGDPIFWGTIRPVLAALGASLALGGNIAGPLLFFFLLNAIRLSTKYYGLK YGYVKGMEILQDLAGNRIQKLTEGASILGLFVMGALVSKWTTINIPIVVSRIKDESGK VDVQTVQNVLDSIMPGALPLGLTLLVAWMLRKGVNPLLIICGIFVIGILGYWAGFLA* " /label="levG CDS" gene complement(2384557..2385384) /gene="levG" /locus_tag="BSU_27040" /old_locus_tag="BSU27040" /label="levG gene" CDS complement(2385405..2386214) /gene="levF" /locus_tag="BSU_27050" /old_locus_tag="BSU27050" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:2117666, 9033408, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2117666, 9033408, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) fructose-specific enzyme IIC component" /protein_id="NP_390583.1" /db_xref="EnsemblGenomes-Gn:BSU27050" /db_xref="EnsemblGenomes-Tr:CAB14647" /db_xref="GOA:P26381" /db_xref="InterPro:IPR004700" /db_xref="SubtiList:BG10318" /db_xref="UniProtKB/Swiss-Prot:P26381" /translation="MSSLQIILLLIIAAITGIASVLDEGQTHRPLVACTLVGLVLGDL KTGIILGGTLELMALGWMNVGLAMAPDTAIASVISTILVITADQGIGEGIAVAVALAA AGQALTIFVRTITVFFIHRADQYAKAGNIKGIEIMHITAMVFQALRVMIPTLIVALIS VSAVQAFLGNIPDVITKGLQIGGGIIVVVGYAMVINMMNIPYLKPFFYIGFLLAAFTD FNLVGFGALGLCLALLYQQVMQKQSAHGAVAAASDSGSVAVYDDDDDDLDA*" /label="levF CDS" gene complement(2385405..2386214) /gene="levF" /locus_tag="BSU_27050" /old_locus_tag="BSU27050" /label="levF gene" CDS complement(2386231..2386719) /gene="levE" /locus_tag="BSU_27060" /old_locus_tag="BSU27060" /EC_number="2.7.1.202" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:2117666, 9033408, 9622354, 10589728" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2117666, 9033408, 9622354, 10589728; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) fructose-specific enzyme IIB component" /protein_id="NP_390584.1" /db_xref="EnsemblGenomes-Gn:BSU27060" /db_xref="EnsemblGenomes-Tr:CAB14648" /db_xref="GOA:P26380" /db_xref="InterPro:IPR004720" /db_xref="InterPro:IPR018455" /db_xref="InterPro:IPR036667" /db_xref="PDB:1BLE" /db_xref="SubtiList:BG10317" /db_xref="UniProtKB/Swiss-Prot:P26380" /translation="MNIVLARIDDRFIHGQILTRWIKVHAADRIIVVSDDIAQDEMRK TLILSVAPSNVKASAVSVSKMAKAFHSPRYEGVTAMLLFENPSDIVSLIEAGVPIKTV NVGGMRFENHRRQITKSVSVTEQDIKAFETLSDKGVKLELRQLPSDASEDFVQILRNV TK*" /label="levE CDS" gene complement(2386231..2386719) /gene="levE" /locus_tag="BSU_27060" /old_locus_tag="BSU27060" /label="levE gene" CDS complement(2386719..2387159) /gene="levD" /locus_tag="BSU_27070" /old_locus_tag="BSU27070" /EC_number="2.7.1.202" /function="16.3: Control" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:2117666, 9033408" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2117666, 9033408; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) fructose-specific enzyme IIA component" /protein_id="NP_390585.1" /db_xref="EnsemblGenomes-Gn:BSU27070" /db_xref="EnsemblGenomes-Tr:CAB14649" /db_xref="GOA:P26379" /db_xref="InterPro:IPR004701" /db_xref="InterPro:IPR013789" /db_xref="InterPro:IPR033887" /db_xref="InterPro:IPR036662" /db_xref="SubtiList:BG10316" /db_xref="UniProtKB/Swiss-Prot:P26379" /translation="MISVIISGHGDFPIALKESSGMIFGEENNLIAVPFFKGEGIQTL QEKYHQALKDIPEEHEVLFLVDIFGGTPYNAAASFIAEDQRMDMAAGVNLPILLEVLS LREHLALKDLLNNLKAMSQQSFQVCSEHLEKVKTANQDTREDEL*" /label="levD CDS" gene complement(2386719..2387159) /gene="levD" /locus_tag="BSU_27070" /old_locus_tag="BSU27070" /label="levD gene" downshifts 2387156 /Source="Nicolas_upshifts" /id="D1381" /incds=0 /nref=2 /ntot=5 /MaxReadThrough="0.496260000000001" /MaxDrop="4.58461" /score="24.8267602" /energy="-16.3" /TU="NA" /idTUdmin="U2080" /TUdmin=3740 /isTUend="FALSE" /label="downshifts" misc_feature complement(2387196..2387214) /Source="Nicolas_upshift_promotors" /id="U2081" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.886113886113886" /psig="0.886113886113886" /xcortree=1498 /SigmaFactorBS="ttgctattggctgaaataacaatgaaaacgcttaacacaact gtgtTGGCACGATCCTTGCATTAtatatggatgtacaaaacaggaaaggagcaataga t" /listShort="levD, levE, levF, levG, S1019, sacC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2387200) /Source="Nicolas_upshifts" /id="U2081" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.886113886113886" /psig="0.886113886113886" /xcortree=1498 /SigmaFactorBS="ttgctattggctgaaataacaatgaaaacgcttaacacaact gtgtTGGCACGATCCTTGCATTAtatatggatgtacaaaacaggaaaggagcaataga t" /listShort="levD, levE, levF, levG, S1019, sacC" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2387349..2390156) /gene="levR" /locus_tag="BSU_27080" /old_locus_tag="BSU27080" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1619665, 1900939, 7592487, 8057358, 9622354, 10589728, 19202299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1619665, 1900939, 7592487, 8057358, 9622354, 10589728, 19202299; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (NifA/NtrC family)" /protein_id="NP_390586.2" /db_xref="EnsemblGenomes-Gn:BSU27080" /db_xref="EnsemblGenomes-Tr:CAB14650" /db_xref="GOA:P23914" /db_xref="InterPro:IPR001550" /db_xref="InterPro:IPR002078" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004701" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR025943" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR033887" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="InterPro:IPR036634" /db_xref="InterPro:IPR036662" /db_xref="SubtiList:BG10677" /db_xref="UniProtKB/Swiss-Prot:P23914" /translation="MRRIDKIYHQLKHNFHDSTLDHLLKIQGNSAKEIAEQLKMERSN VSFELNNLVRSKKVIKIKTFPVRYIPVEIAEKLFNKKWDTEMMEVKDLQAFSGNSKQN HQHISTNPLELMIGAKGSLKKAISQAKAAVFYPPNGLHMLLLGPTGSGKSLFANRIYQ FAIYSDILKAGAPFITFNCADYYNNPQLLLSQLFGHKKGSFTGAAEDKAGLVEQANGG ILFMDEIHRLPPEGQEMLFYFIDSGSYNRLGESEHKRTSNVLFICATTENPSSALLKT FLRRIPMTIHIPSLEERSLNERVDLTTFLLGKEAERIKKNLSVHIDVYNALIHSAKFG NVGQLKSNVQLVCAHGFLHNLDRNEVIELTVRDLPDEIKQEWMSSSKNMQRSKAISEY VNITTIISPIVEDETTKIDEDLSFNLYHLIEEKVKTLMKEGLSKKDINQYILTDVHLH VRSFFHHQAFQKDNLLTFVEDDVIQMTKQLKEIAEHELDCTFDRKFIYFLSMHIDAFL KRGKQIDVLNTQETDEIRDTHVKEYRVAMIFKDKIQEYFKVAIPEIEVIYLTMLIHSI KSLKENKRVGIIVAAHGNSTASSMVEVATELLGSTPIAAVDMPLTVSPSDILECVAEK MKQVDEGEGVLMLVDMGSLAMLESRLEEKTGISIKTISNVTTSMVLDAVRKVNYLNLN LHAIYQSVTKDFIELWERQPAASGKKKALVSICTTGSGTAKKLEDILTTIVNKASDTP IHILTVSSIKLANSIKEIEKEYEILATVGTKDPKINAPHVSLEVLIEGEGEKLIQQAI TKGSISLSNGLNEANIIVRELCEDSLKKYLVFLNPHHVIDMLLEWLQTVQDELGVIFN NAVLIKVIMHTAFAFERVIKQNPIAFSEEEEINDQLKEMVYVTERTLAPYEEKLGLRI SDDEKLFIAAIFAEEVHGQLF*" /label="levR CDS" gene complement(2387349..2390156) /gene="levR" /locus_tag="BSU_27080" /old_locus_tag="BSU27080" /label="levR gene" misc_feature complement(2390372..2390391) /Source="Nicolas_upshift_promotors" /id="U2082" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.743256743256743" /psig="0.957042957042957" /xcortree=2981 /SigmaFactorBS="attcattttttgtcattgattattttgacatcattacattcc ccgagAATGATAAACTGTTTACTGAttattacttttgaaggggactggccctccagaa c" /listShort="levR" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2390378) /Source="Nicolas_upshifts" /id="U2082" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.743256743256743" /psig="0.957042957042957" /xcortree=2981 /SigmaFactorBS="attcattttttgtcattgattattttgacatcattacattcc ccgagAATGATAAACTGTTTACTGAttattacttttgaaggggactggccctccagaa c" /listShort="levR" /GFF_Attribute="listLong" /label="upshifts" CDS 2390703..2390843 /locus_tag="BSU_27085" /old_locus_tag="BSU27085" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513990.1" /translation="MTFLFYSAIQVESRVKNRATRHVTALKIVLKFKNKSIYSFKCYN IR*" /label="hypothetical protein CDS" gene 2390703..2390843 /locus_tag="BSU_27085" /old_locus_tag="BSU27085" /label="gene" misc_feature 2390824..2390843 /Source="Nicolas_upshift_promotors" /id="U2083" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.929070929070929" /psig="0.997002997002997" /xcortree=1762 /SigmaFactorBS="agcacttaaaatagttttaaaatttaaaaataaaagtatcta ttcttttaAATGTTATAATATCCGATAAaactttactcatctttttattactggagga a" /listShort="aapA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2390834 /Source="Nicolas_upshifts" /id="U2083" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.929070929070929" /psig="0.997002997002997" /xcortree=1762 /SigmaFactorBS="agcacttaaaatagttttaaaatttaaaaataaaagtatcta ttcttttaAATGTTATAATATCCGATAAaactttactcatctttttattactggagga a" /listShort="aapA" /GFF_Attribute="listLong" /label="upshifts" CDS 2390882..2392270 /gene="aapA" /locus_tag="BSU_27090" /old_locus_tag="BSU27090" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16850406, 17608695, 22084243; Product type t: transporter" /codon_start=1 /transl_table=11 /product="small amino acid permease" /protein_id="NP_390587.2" /db_xref="EnsemblGenomes-Gn:BSU27090" /db_xref="EnsemblGenomes-Tr:CAB14651" /db_xref="GOA:O06005" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG12556" /db_xref="UniProtKB/Swiss-Prot:O06005" /translation="MIGNSSKDNFGQQQKLSRGLKNRHIQLMAIGGAIGTGLFLGSGK SIHFAGPSILFAYLITGVFCFFIMRSLGELLLSNAGYHSFVDFVRDYLGNMAAFITGW TYWFCWISLAMADLTAVGIYTQYWLPDVPQWLPGLLALIILLIMNLATVKLFGELEFW FALIKVIAILALIVTGILLIAKGFSAASGPASLNNLWSHGGMFPNGWHGFILSFQMVV FAFVGIELVGLTAGETENPQKVIPKAINQIPVRILLFYVGALFVIMCIYPWNVLNPNE SPFVQVFSAVGIVVAASLINFVVLTSAASAANSALFSTSRMVYSLAKDHHAPGLLKKL TSSNVPSNALFFSSIAILIGVSLNYLMPEQVFTLITSVSTICFIFIWGITVICHLKYR KTRQHEAKANKFKMPFYPLSNYLTLAFLAFILVILALANDTRIALFVTPVWFVLLIIL YKVQTRRGHKVK*" /label="aapA CDS" gene 2390882..2392270 /gene="aapA" /locus_tag="BSU_27090" /old_locus_tag="BSU27090" /label="aapA gene" downshifts 2392259 /Source="Nicolas_upshifts" /id="D1382" /incds=0 /nref=7 /ntot=120 /MaxReadThrough="0.96985" /MaxDrop="3.54068" /score="11.8049306" /energy="-13" /TU="NA" /idTUdmin="U2083" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" S_feature complement(2392292..2392365) /Source="Nicolas_S_feature" /locus_tag="new_2767968_2768041_c" /HighExp="MG 120, LBGstat, MG 150, MG 90, S0, HPh, HiOs, GM-0.1, aero, GM 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1020" downshifts complement(2392334) /Source="Nicolas_upshifts" /id="D1383" /incds=0 /nref=11 /ntot=121 /MaxReadThrough="1.79954" /MaxDrop="4.59487" /score="37.881034" /energy="-13" /TU="NA" /idTUdmin="U2084" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2392366..2392998) /gene="yrhP" /locus_tag="BSU_27100" /old_locus_tag="BSU27100" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16098526, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative amino acid exporter" /protein_id="NP_390588.1" /db_xref="EnsemblGenomes-Gn:BSU27100" /db_xref="EnsemblGenomes-Tr:CAB14652" /db_xref="GOA:O05406" /db_xref="InterPro:IPR001123" /db_xref="InterPro:IPR004778" /db_xref="SubtiList:BG12304" /db_xref="UniProtKB/Swiss-Prot:O05406" /translation="MHSLLAYIPIAAMMVIIPGADTMLVMKNTLRYGPKAGRYNILGL ATGLSFWTVIAILGLSVVIAKSVILFTTIKYLGAAYLIYLGVKSFFAKSMFSLDDMQS QAKNMASSPKRYYKTSFMQGSLSNILNPKTVLVYVTIMPQFINLNGNINQQLIILASI LTLLAVLWFLFLVYIIDYAKKWMKNSKFQKVFQKITGIILVGFGIKTGLS*" /label="yrhP CDS" gene complement(2392366..2392998) /gene="yrhP" /locus_tag="BSU_27100" /old_locus_tag="BSU27100" /label="yrhP gene" downshifts complement(2392422) /Source="Nicolas_upshifts" /id="D1384" /incds=0 /nref=4 /ntot=132 /MaxReadThrough="4.46187" /MaxDrop="3.11632" /score="37.881034" /energy="-13" /TU="U2084" /idTUdmin="U2084" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2393052..2393071) /Source="Nicolas_upshift_promotors" /id="U2084" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.717282717282717" /psig=1 /xcortree=2999 /SigmaFactorBS="tgccttagtaatcgctattttaacaaatcaTATTGATTtatt ccaaacgcatTGATACACTTTTATAAGTAGttacttttgtagtcactatatgattgag g" /listShort="yrhP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2393063) /Source="Nicolas_upshifts" /id="U2084" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.717282717282717" /psig=1 /xcortree=2999 /SigmaFactorBS="tgccttagtaatcgctattttaacaaatcaTATTGATTtatt ccaaacgcatTGATACACTTTTATAAGTAGttacttttgtagtcactatatgattgag g" /listShort="yrhP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2393077..2393083 /Source="Nicolas_upshift_promotors" /id="U2085" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.402597402597403" /psig=1 /xcortree=1861 /SigmaFactorBS="acaaaagtaactacttataaaagtgtatcaatgcgTTTGGAA taaatcaatatgaTTTGTTAAAATAGCGATTACtaaggcagcgattgctctttatatt g" /listShort="yrhO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2393086..2393093) /Source="Nicolas_upshift_promotors" /id="U2084" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.717282717282717" /psig=1 /xcortree=2999 /SigmaFactorBS="tgccttagtaatcgctattttaacaaatcaTATTGATTtatt ccaaacgcatTGATACACTTTTATAAGTAGttacttttgtagtcactatatgattgag g" /listShort="yrhP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2393097..2393116 /Source="Nicolas_upshift_promotors" /id="U2085" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.402597402597403" /psig=1 /xcortree=1861 /SigmaFactorBS="acaaaagtaactacttataaaagtgtatcaatgcgTTTGGAA taaatcaatatgaTTTGTTAAAATAGCGATTACtaaggcagcgattgctctttatatt g" /listShort="yrhO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2393102 /Source="Nicolas_upshifts" /id="U2085" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.402597402597403" /psig=1 /xcortree=1861 /SigmaFactorBS="acaaaagtaactacttataaaagtgtatcaatgcgTTTGGAA taaatcaatatgaTTTGTTAAAATAGCGATTACtaaggcagcgattgctctttatatt g" /listShort="yrhO" /GFF_Attribute="listLong" /label="upshifts" CDS 2393151..2393978 /gene="yrhO" /locus_tag="BSU_27110" /old_locus_tag="BSU27110" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator controlling amino acid export" /protein_id="NP_390589.1" /db_xref="EnsemblGenomes-Gn:BSU27110" /db_xref="EnsemblGenomes-Tr:CAB14653" /db_xref="InterPro:IPR002831" /db_xref="InterPro:IPR021586" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12303" /db_xref="UniProtKB/Swiss-Prot:O05405" /translation="MKENMLDILKNLNFTEYESKAYLALLQESPLTGYAVAKKSGVPR SKIYEVLESLVIRGDVFVSHGNTPQYVPVPAKELIKNRRLKAEEHFDQAEKYFEKFEQ TANDRENIWNITGRSEILEKVKACILSAKKRILLEIWKEDFKEIEAELKQAAEQGVIV TIIAYGDIVSDFANVYLHDMSSEITEEYDGRWLVYSGDDSEVVAGIVSLGNDSRAAWT MHVGLVMPITEVIIHDLYLMEILKKHRELLEESFGKNLIQLRRKFSIHSDFKKHYLE* " /label="yrhO CDS" gene 2393151..2393978 /gene="yrhO" /locus_tag="BSU_27110" /old_locus_tag="BSU27110" /label="yrhO gene" downshifts 2393974 /Source="Nicolas_upshifts" /id="D1385" /incds=0 /nref=57 /ntot=233 /MaxReadThrough="0.74814" /MaxDrop="5.12635" /score="6.64108595" /energy="-9.5" /TU="NA" /idTUdmin="U2085" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2394091..2394100 /Source="Nicolas_upshift_promotors" /id="U2086" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.874125874125874" /psig="0.874125874125874" /xcortree=1440 /SigmaFactorBS="tttacttctctcttttaaaaaatgtgattctgcGCAAACTAT TtttcagcctgccGCGTCTATCCTAGGTAacagcctacgatatacgtatattcaaaaa g" /listShort="sigV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2394113..2394128 /Source="Nicolas_upshift_promotors" /id="U2086" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.874125874125874" /psig="0.874125874125874" /xcortree=1440 /SigmaFactorBS="tttacttctctcttttaaaaaatgtgattctgcGCAAACTAT TtttcagcctgccGCGTCTATCCTAGGTAacagcctacgatatacgtatattcaaaaa g" /listShort="sigV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2394118 /Source="Nicolas_upshifts" /id="U2086" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.874125874125874" /psig="0.874125874125874" /xcortree=1440 /SigmaFactorBS="tttacttctctcttttaaaaaatgtgattctgcGCAAACTAT TtttcagcctgccGCGTCTATCCTAGGTAacagcctacgatatacgtatattcaaaaa g" /listShort="sigV" /GFF_Attribute="listLong" /label="upshifts" CDS 2394174..2394674 /gene="sigV" /locus_tag="BSU_27120" /old_locus_tag="BSU27120" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16274938, 21926231, 23687273, 26901131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16274938, 21926231, 23687273, 26901131; Product type r: regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase ECF(extracytoplasmic function)-type sigma factor (sigma(V))" /protein_id="NP_390590.1" /db_xref="EnsemblGenomes-Gn:BSU27120" /db_xref="EnsemblGenomes-Tr:CAB14654" /db_xref="GOA:O05404" /db_xref="InterPro:IPR000838" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11974" /db_xref="UniProtKB/Swiss-Prot:O05404" /translation="MKKKQTTKALLVTCITDHKQDFYRLAFSYVKNQDDALDIVQESI KKALSSVETVRNPETIKSWFYKILVRTAIDFLRKQKKIRVMDDETIEFLSKGKEDHYK DTDLHEALDELPYRYKTIIILRFFEDLKLEEIAEITGENTNTVKTRLYRALKLMRIQL TKEDLS*" /label="sigV CDS" gene 2394174..2394674 /gene="sigV" /locus_tag="BSU_27120" /old_locus_tag="BSU27120" /label="sigV gene" CDS 2394674..2395531 /gene="rsiV" /locus_tag="BSU_27130" /old_locus_tag="BSU27130" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16274938, 23687273, 26901131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16274938, 23687273, 26901131; Product type r: regulator" /codon_start=1 /transl_table=11 /product="anti-sigma(V) factor" /protein_id="NP_390591.1" /db_xref="EnsemblGenomes-Gn:BSU27130" /db_xref="EnsemblGenomes-Tr:CAB14655" /db_xref="GOA:O05403" /db_xref="InterPro:IPR021729" /db_xref="InterPro:IPR025303" /db_xref="InterPro:IPR037126" /db_xref="PDB:5JEN" /db_xref="SubtiList:BG12302" /db_xref="UniProtKB/Swiss-Prot:O05403" /translation="MDKRLQQLREEYKNVQIPKELDIIVEKALQQEPKKKRIVMWPTS AAIAAAILFTALVNINPDAAQAMSKIPVIGKIVKAITFIEIKEEKDQSSIDVKTPALS GLSNKELENSINEKYLKESQQLYKEFIQSTSKNKKGHLSIYSDYETVTDTPDLLSIRR NIETTQASSYTQSRYITIDKKNDILLTLKSLFKDERYIKVISQNIKEQMKQQMKEDPN KIYWLTDEDAEPFKTILPDQTFYITEDHKLVISFDEYEVAPGYMGVTEFTIPTGVISN LLVGERYIR*" /label="rsiV CDS" gene 2394674..2395531 /gene="rsiV" /locus_tag="BSU_27130" /old_locus_tag="BSU27130" /label="rsiV gene" promotor_-10 complement(2395549..2395560) /Source="Nicolas_upshift_promotors" /id="U2087" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.784215784215784" /psig="0.784215784215784" /xcortree=1210 /SigmaFactorBS="atagtatgcaaatattctcgttgtttttgatagcggggttac gacctCGAATAGagaagagagaaaacATCCATAATCTTagatggatgtttttatttta t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2395568) /Source="Nicolas_upshifts" /id="U2087" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.784215784215784" /psig="0.784215784215784" /xcortree=1210 /SigmaFactorBS="atagtatgcaaatattctcgttgtttttgatagcggggttac gacctCGAATAGagaagagagaaaacATCCATAATCTTagatggatgtttttatttta t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2395575..2395581) /Source="Nicolas_upshift_promotors" /id="U2087" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.784215784215784" /psig="0.784215784215784" /xcortree=1210 /SigmaFactorBS="atagtatgcaaatattctcgttgtttttgatagcggggttac gacctCGAATAGagaagagagaaaacATCCATAATCTTagatggatgtttttatttta t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2395642..2397546 /gene="oatA" /locus_tag="BSU_27140" /old_locus_tag="BSU27140" /EC_number="2.3.1.-" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:1521192, 15661003, 21135105, 21586574, 21856855, 21926231" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1521192, 15661003, 21135105, 21586574, 21856855, 21926231; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="peptidoglycan O-acetyltransferase" /protein_id="NP_390592.1" /db_xref="EnsemblGenomes-Gn:BSU27140" /db_xref="EnsemblGenomes-Tr:CAB14656" /db_xref="GOA:O05402" /db_xref="InterPro:IPR002656" /db_xref="InterPro:IPR036514" /db_xref="SubtiList:BG12301" /db_xref="UniProtKB/Swiss-Prot:O05402" /translation="MYHKTQHHRYIPGLDGLRAFAVLSVITYHLNFNWANGGFIGVDI FFVLSGYLITSILLPAYGNDINLDFRDFWVRRIRRLLPAAYLMIFSTVVWVVLFDREL LHTVRGDAISSLFYMSNWWFIFHKLSYFDSFGSPSPLKNLWSLAIEEQFYIIWPMFLV VGMYIMKSRARLAAVISLLVLCSAVMMSVLYEPGGDPSRVYYGTDTRSFELLIGCALA LVWPMKRLSSNRLPSKLKHTLHATEFLAFCILVLCVYFTDEYEPFLYRGGMLFISVTA AILIACVCHPSSFLGNLLSWRPLRWLGTRSYGIYLWHYPVIVLSTPVQEIGNPVFWHI VLKVIVTCILAELSYHFIEKPIRTQGFRSFSRRVFIHRIKEWKTTSVISKMSIGFIIF AILIFAGGLSGLAGEQKHPTKWTYSSQETNADTSQASGDKKNAAADKKHNPEQKTTDS NQGQKENKDSGQETHKKKDTQSQQLKKPADTAKEVLAIGDSVMLDISSHLRQSFSNVT IDGKVGRQMSQALELAREYKSFNQPNKAVIIELGTNGYFTNSQIEQLLQSFSKAHIYL VNTRVPRQWESKVNESLQQQAHAHQNVTLVDWHTEALQHPEYFTPDGVHLVPKGAKTL TALIVQAMKS*" /label="oatA CDS" gene 2395642..2397546 /gene="oatA" /locus_tag="BSU_27140" /old_locus_tag="BSU27140" /label="oatA gene" promotor_-35 2397627..2397633 /Source="Nicolas_upshift_promotors" /id="U2088" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=182 /SigmaFactorBS="gattatgtcttctttcagcaaggcagcccttaTGTTTACatg ccgtttacgtaaGGGTAAGCCAAAATTGAATggagggatgataatgaaaggaaatgaa g" /listShort="yrhK, S1021, S1022" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2397649..2397667 /Source="Nicolas_upshift_promotors" /id="U2088" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=182 /SigmaFactorBS="gattatgtcttctttcagcaaggcagcccttaTGTTTACatg ccgtttacgtaaGGGTAAGCCAAAATTGAATggagggatgataatgaaaggaaatgaa g" /listShort="yrhK, S1021, S1022" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2397655 /Source="Nicolas_upshifts" /id="U2088" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=182 /SigmaFactorBS="gattatgtcttctttcagcaaggcagcccttaTGTTTACatg ccgtttacgtaaGGGTAAGCCAAAATTGAATggagggatgataatgaaaggaaatgaa g" /listShort="yrhK, S1021, S1022" /GFF_Attribute="listLong" /label="upshifts" CDS 2397680..2397970 /gene="yrhK" /locus_tag="BSU_27150" /old_locus_tag="BSU27150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 21926231" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390593.1" /db_xref="EnsemblGenomes-Gn:BSU27150" /db_xref="EnsemblGenomes-Tr:CAB14657" /db_xref="GOA:O05401" /db_xref="InterPro:IPR025424" /db_xref="SubtiList:BG12300" /db_xref="UniProtKB/Swiss-Prot:O05401" /translation="MKGNEEHDIQKELKRYELFFKKRYKVLYTVNDFIIGAMFLVGSF FFFYDRLMSAGIWLFAIGSLLLLIRPTIRLIHDFHYRKHVEQQFKHQSSTDD*" /label="yrhK CDS" gene 2397680..2397970 /gene="yrhK" /locus_tag="BSU_27150" /old_locus_tag="BSU27150" /label="yrhK gene" S_feature 2397971..2398086 /Source="Nicolas_S_feature" /locus_tag="new_2773647_2773762" /HighExp="Etha, Salt, LPhT, HiTm, G135, LBGstat, G180, G150, Heat, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1021" promotor_-35 2398068..2398075 /Source="Nicolas_upshift_promotors" /id="U2089" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=79 /SigmaFactorBS="gactttcagactatttatttttaaaaacaaggtaaaaagaAC TAAACTtttgcctctgcatGCCGATATGAATAATAAGGccggcgcgatactccctata a" /listShort="S1022" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2398088..2398213 /Source="Nicolas_S_feature" /locus_tag="new_2773764_2773889" /HighExp="Gly, G/S, Lbstat, C90, Pyr, LPhT, LoTm, Etha, T0.30H, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigB" /TUshortPSig="0.998, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1022" upshifts 2398088 /Source="Nicolas_upshifts" /id="U2089" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=79 /SigmaFactorBS="gactttcagactatttatttttaaaaacaaggtaaaaagaAC TAAACTtttgcctctgcatGCCGATATGAATAATAAGGccggcgcgatactccctata a" /listShort="S1022" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2398089..2398107 /Source="Nicolas_upshift_promotors" /id="U2089" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=79 /SigmaFactorBS="gactttcagactatttatttttaaaaacaaggtaaaaagaAC TAAACTtttgcctctgcatGCCGATATGAATAATAAGGccggcgcgatactccctata a" /listShort="S1022" /GFF_Attribute="listLong" /label="promotor_-10" misc_RNA 2398107..2398207 /gene="surF" /locus_tag="BSU_misc_RNA_82" /product="small untranslated RNA expressed under sporulation conditions (SurF-AbrB)" /experiment="publication(s) with functional evidences, PMID:20709900, 25790031" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20709900, 25790031; Product type n: RNA" /label="surF RNA" gene 2398107..2398207 /gene="surF" /locus_tag="BSU_misc_RNA_82" /label="surF gene" downshifts 2398170 /Source="Nicolas_upshifts" /id="D1386" /incds=0 /nref=7 /ntot=129 /MaxReadThrough="3.60641" /MaxDrop="5.24336" /score="25.0079309" /energy="-15.8" /TU="U2089" /idTUdmin="U2088" /TUdmin=16 /isTUend="TRUE" /label="downshifts" CDS complement(2398214..2401378) /gene="cypB" /locus_tag="BSU_27160" /old_locus_tag="BSU27160" /EC_number="1.14.14.1" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11574077, 12775685" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11574077, 12775685; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome P450 CYP102A3" /protein_id="NP_390594.1" /db_xref="EnsemblGenomes-Gn:BSU27160" /db_xref="EnsemblGenomes-Tr:CAB14658" /db_xref="GOA:O08336" /db_xref="InterPro:IPR001094" /db_xref="InterPro:IPR001128" /db_xref="InterPro:IPR001433" /db_xref="InterPro:IPR001709" /db_xref="InterPro:IPR003097" /db_xref="InterPro:IPR008254" /db_xref="InterPro:IPR017927" /db_xref="InterPro:IPR017938" /db_xref="InterPro:IPR017972" /db_xref="InterPro:IPR023206" /db_xref="InterPro:IPR029039" /db_xref="InterPro:IPR036396" /db_xref="SubtiList:BG12299" /db_xref="UniProtKB/Swiss-Prot:O08336" /translation="MKQASAIPQPKTYGPLKNLPHLEKEQLSQSLWRIADELGPIFRF DFPGVSSVFVSGHNLVAEVCDEKRFDKNLGKGLQKVREFGGDGLFTSWTHEPNWQKAH RILLPSFSQKAMKGYHSMMLDIATQLIQKWSRLNPNEEIDVADDMTRLTLDTIGLCGF NYRFNSFYRDSQHPFITSMLRALKEAMNQSKRLGLQDKMMVKTKLQFQKDIEVMNSLV DRMIAERKANPDENIKDLLSLMLYAKDPVTGETLDDENIRYQIITFLIAGHETTSGLL SFAIYCLLTHPEKLKKAQEEADRVLTDDTPEYKQIQQLKYIRMVLNETLRLYPTAPAF SLYAKEDTVLGGEYPISKGQPVTVLIPKLHRDQNAWGPDAEDFRPERFEDPSSIPHHA YKPFGNGQRACIGMQFALQEATMVLGLVLKHFELINHTGYELKIKEALTIKPDDFKIT VKPRKTAAINVQRKEQADIKAETKPKETKPKHGTPLLVLFGSNLGTAEGIAGELAAQG RQMGFTAETAPLDDYIGKLPEEGAVVIVTASYNGAPPDNAAGFVEWLKELEEGQLKGV SYAVFGCGNRSWASTYQRIPRLIDDMMKAKGASRLTAIGEGDAADDFESHRESWENRF WKETMDAFDINEIAQKEDRPSLSITFLSEATETPVAKAYGAFEGIVLENRELQTAAST RSTRHIELEIPAGKTYKEGDHIGILPKNSRELVQRVLSRFGLQSNHVIKVSGSAHMAH LPMDRPIKVVDLLSSYVELQEPASRLQLRELASYTVCPPHQKELEQLVSDDGIYKEQV LAKRLTMLDFLEDYPACEMPFERFLALLPSLKPRYYSISSSPKVHANIVSMTVGVVKA SAWSGRGEYRGVASNYLAELNTGDAAACFIRTPQSGFQMPNDPETPMIMVGPGTGIAP FRGFIQARSVLKKEGSTLGEALLYFGCRRPDHDDLYREELDQAEQDGLVTIRRCYSRV ENEPKGYVQHLLKQDTQKLMTLIEKGAHIYVCGDGSQMAPDVERTLRLAYEAEKAASQ EESAVWLQKLQDQRRYVKDVWTGM*" /label="cypB CDS" gene complement(2398214..2401378) /gene="cypB" /locus_tag="BSU_27160" /old_locus_tag="BSU27160" /label="cypB gene" downshifts complement(2398230) /Source="Nicolas_upshifts" /id="D1387" /incds=0 /nref=25 /ntot=213 /MaxReadThrough="2.3596" /MaxDrop="4.0425" /score="-9.99429269" /energy="-17.6" /TU="NA" /idTUdmin="U2091" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2399364..2399373 /Source="Nicolas_upshift_promotors" /id="U2090" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1249 /SigmaFactorBS="ctggagttctcgattcTCTAACACAAtcccttcaaacgcGCC ATATGCTTTAGCAACCGgcgtttccgtcgcttcactgagaaaagtaatcgataatgaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2399387..2399406 /Source="Nicolas_upshift_promotors" /id="U2090" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1249 /SigmaFactorBS="ctggagttctcgattcTCTAACACAAtcccttcaaacgcGCC ATATGCTTTAGCAACCGgcgtttccgtcgcttcactgagaaaagtaatcgataatgaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2399408 /Source="Nicolas_upshifts" /id="U2090" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1249 /SigmaFactorBS="ctggagttctcgattcTCTAACACAAtcccttcaaacgcGCC ATATGCTTTAGCAACCGgcgtttccgtcgcttcactgagaaaagtaatcgataatgaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2401394..2401978) /gene="bscR" /locus_tag="BSU_27170" /old_locus_tag="BSU27170" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11574077" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11574077; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator for cypB" /protein_id="NP_390595.1" /db_xref="EnsemblGenomes-Gn:BSU27170" /db_xref="EnsemblGenomes-Tr:CAB14659" /db_xref="GOA:O08335" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR023772" /db_xref="InterPro:IPR032551" /db_xref="SubtiList:BG12298" /db_xref="UniProtKB/Swiss-Prot:O08335" /translation="MISASSSKYDMIMKASVSLFTERGFDATTIPMIAERAHVGTGTI YRYFDSKETLVNVLFQESIQRFTEKLKQDVSELPVREGFHHVFCCLVQFTKESDYALF FLETKKDAHYLNHTSKKMIENLTQMLDDYFNKGKAEGVIRSLPSNVLIAIVLGAFLKI YQLVQTGDIEMDTDLITELEQCCWDAIKLHSSQK*" /label="bscR CDS" gene complement(2401394..2401978) /gene="bscR" /locus_tag="BSU_27170" /old_locus_tag="BSU27170" /label="bscR gene" CDS complement(2402201..2402743) /gene="yrhH" /locus_tag="BSU_27180" /old_locus_tag="BSU27180" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15870467; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative methyltransferase" /protein_id="NP_390596.1" /db_xref="EnsemblGenomes-Gn:BSU27180" /db_xref="EnsemblGenomes-Tr:CAB14660" /db_xref="GOA:O05400" /db_xref="InterPro:IPR013216" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG12297" /db_xref="UniProtKB/Swiss-Prot:O05400" /translation="MLENRLYKRSDFWKLFSRKYKLTKTIEHMMIDSIDIQENDRILE IGIGNGTVFKSITKKLKKGSLKSIDPSKRKVRQISRANRKNMGNGEVFHGYPEDIPFD DRTFNKVFSLHTVQSCTDIRLALREIYRVLQIDGRFYISIDTNTGEKEKTYIQLLKDQ HFRDLSVIRRASCLCIVAVK*" /label="yrhH CDS" gene complement(2402201..2402743) /gene="yrhH" /locus_tag="BSU_27180" /old_locus_tag="BSU27180" /label="yrhH gene" S_feature complement(2402744..2402829) /Source="Nicolas_S_feature" /locus_tag="new_2778420_2778505_c" /HighExp="T-0.40H, Salt, T0.30H, Heat, T0.0H, Etha, T-1.10H, T-1.40H, T1.0H, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S1023" promotor_-10 complement(2402827..2402842) /Source="Nicolas_upshift_promotors" /id="U2091" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1647 /SigmaFactorBS="aaaaaatgaaaaagtttagttctatTGAAACATTTttcaata cattgCCGTCTAGTTGGTACCttccttcacttttagaaatgaagatgatgtttatttt t" /listShort="S1023, yrhH, bscR, cypB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2402829) /Source="Nicolas_upshifts" /id="U2091" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1647 /SigmaFactorBS="aaaaaatgaaaaagtttagttctatTGAAACATTTttcaata cattgCCGTCTAGTTGGTACCttccttcacttttagaaatgaagatgatgtttatttt t" /listShort="S1023, yrhH, bscR, cypB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2402855..2402864) /Source="Nicolas_upshift_promotors" /id="U2091" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1647 /SigmaFactorBS="aaaaaatgaaaaagtttagttctatTGAAACATTTttcaata cattgCCGTCTAGTTGGTACCttccttcacttttagaaatgaagatgatgtttatttt t" /listShort="S1023, yrhH, bscR, cypB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2402898..2403114) /Source="Nicolas_S_feature" /locus_tag="new_2778574_2778790_c" /HighExp="S7, S8, S6, LPhT, BT, LBGstat, S5, B36, G/S, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99909999999999999" /TUshortSig="SigK, SigA" /TUshortPSig="0.999, 0.998" /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S1024" CDS complement(2402932..2403090) /locus_tag="BSU_27185" /old_locus_tag="BSU27185" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513991.1" /translation="MMNDYQKRLPSIGHGYASMPHSFKHGYGNPFRQQRLMAMQQQRL YVFPYHWH*" /label="hypothetical protein CDS" gene complement(2402932..2403090) /locus_tag="BSU_27185" /old_locus_tag="BSU27185" /label="gene" downshifts complement(2402941) /Source="Nicolas_upshifts" /id="D1388" /incds=0 /nref=34 /ntot=184 /MaxReadThrough="3.04168" /MaxDrop="7.65849" /score="23.6695072" /energy="-11.3" /TU="U2093" /idTUdmin="U2092" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2403112..2403131) /Source="Nicolas_upshift_promotors" /id="U2092" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1229 /SigmaFactorBS="aaggaccaagtttagcgaaaTAGCTGTCAAgaaaatgcgcgc cTGCATATAGTAAATCAACGTtattgtgaggcaggtgatggcatgatgaacgattatc a" /listShort="S1024" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2403114) /Source="Nicolas_upshifts" /id="U2092" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1229 /SigmaFactorBS="aaggaccaagtttagcgaaaTAGCTGTCAAgaaaatgcgcgc cTGCATATAGTAAATCAACGTtattgtgaggcaggtgatggcatgatgaacgattatc a" /listShort="S1024" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2403116..2403246) /Source="Nicolas_S_feature" /locus_tag="new_2778792_2778922_c" /HighExp="S7, S8, LPhT, S6, LBGstat, B36, BT, S5, Cold, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.893648" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1025" promotor_-35 complement(2403145..2403154) /Source="Nicolas_upshift_promotors" /id="U2092" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1229 /SigmaFactorBS="aaggaccaagtttagcgaaaTAGCTGTCAAgaaaatgcgcgc cTGCATATAGTAAATCAACGTtattgtgaggcaggtgatggcatgatgaacgattatc a" /listShort="S1024" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2403247..2403396) /gene="yrzI" /locus_tag="BSU_27190" /old_locus_tag="BSU27190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390597.1" /db_xref="EnsemblGenomes-Gn:BSU27190" /db_xref="EnsemblGenomes-Tr:CAB14661" /db_xref="InterPro:IPR012655" /db_xref="SubtiList:BG13819" /db_xref="UniProtKB/Swiss-Prot:O32027" /translation="MTINLFFLTLTIKKRFKSLEEFEREQQIEQIYDEMKESQLKHLY LTNWR*" /label="yrzI CDS" gene complement(2403247..2403396) /gene="yrzI" /locus_tag="BSU_27190" /old_locus_tag="BSU27190" /label="yrzI gene" downshifts 2403390 /Source="Nicolas_upshifts" /id="D1389" /incds=0 /nref=4 /ntot=35 /MaxReadThrough="1.96539" /MaxDrop="3.70444" /score="-6.5827622" /energy="-7.8" /TU="NA" /idTUdmin="U2089" /TUdmin=4972 /isTUend="FALSE" /label="downshifts" S_feature complement(2403397..2403487) /Source="Nicolas_S_feature" /locus_tag="new_2779073_2779163_c" /HighExp="S7, LBGstat, Cold, S6, B36, LPhT, T-0.40H, LoTm, S8, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1026" S_feature complement(2403489..2403708) /Source="Nicolas_S_feature" /locus_tag="new_2779165_2779384_c" /HighExp="B60, B36, S7, BT, LBGstat, Cold, LoTm, LPhT, S6, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.52109300000000003" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1027" downshifts complement(2403532) /Source="Nicolas_upshifts" /id="D1390" /incds=0 /nref=2 /ntot=37 /MaxReadThrough="7.23426" /MaxDrop="3.6023" /score="11.9275075" /energy="-19.6" /TU="U2093,U2094" /idTUdmin="U2094" /TUdmin="-440" /isTUend="FALSE" /label="downshifts" downshifts 2403654 /Source="Nicolas_upshifts" /id="D1391" /incds=0 /nref=16 /ntot=94 /MaxReadThrough="0.94778" /MaxDrop="4.28987" /score="-6.5827622" /energy="-7.8" /TU="NA" /idTUdmin="U2089" /TUdmin=5236 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2403687..2403706) /Source="Nicolas_upshift_promotors" /id="U2093" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.984015984015984" /psig="0.998001998001998" /xcortree=590 /SigmaFactorBS="tcgatgatttgcacaatttccgtccatttttagaaaaagaTG TTTACAaaatggaatttggtGGATATACTTACAAAGTAAGaaaaaagcaaaggaggct g" /listShort="S1027, S1026, yrzI, S1025, S1024, S1023, yrhH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2403708) /Source="Nicolas_upshifts" /id="U2093" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.984015984015984" /psig="0.998001998001998" /xcortree=590 /SigmaFactorBS="tcgatgatttgcacaatttccgtccatttttagaaaaagaTG TTTACAaaatggaatttggtGGATATACTTACAAAGTAAGaaaaaagcaaaggaggct g" /listShort="S1027, S1026, yrzI, S1025, S1024, S1023, yrhH" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2403710..2403785) /Source="Nicolas_S_feature" /locus_tag="new_2779386_2779461_c" /HighExp="Lbexp, dia0, dia5, G150, Cold, C30, Mt0, LBGexp, dia15, Etha" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.115567" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1028" promotor_-35 complement(2403721..2403728) /Source="Nicolas_upshift_promotors" /id="U2093" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.984015984015984" /psig="0.998001998001998" /xcortree=590 /SigmaFactorBS="tcgatgatttgcacaatttccgtccatttttagaaaaagaTG TTTACAaaatggaatttggtGGATATACTTACAAAGTAAGaaaaaagcaaaggaggct g" /listShort="S1027, S1026, yrzI, S1025, S1024, S1023, yrhH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2403786..2404586) /gene="yrhG" /locus_tag="BSU_27200" /old_locus_tag="BSU27200" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 24887098; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative formate/nitrite transporter" /protein_id="NP_390598.1" /db_xref="EnsemblGenomes-Gn:BSU27200" /db_xref="EnsemblGenomes-Tr:CAB14662" /db_xref="GOA:O05399" /db_xref="InterPro:IPR000292" /db_xref="InterPro:IPR023271" /db_xref="InterPro:IPR024002" /db_xref="SubtiList:BG12296" /db_xref="UniProtKB/Swiss-Prot:O05399" /translation="MAFRKPDEIAEAAIEAGMKKIKLPLPSLLVLGFLGGAFIALGYL LDIRVIGDLPKEWGSLSSLIGAAVFPVGLILVVLAGAELITGNMMSVAMALFSRKISV KELAINWGIVTIMNLIGALFVAYFFGHLVGLTETGPYLEKTIAVAQGKLDMSFGKVLI SAIGCNWLVCLAVWLSFGAQDAAGKILGIWFPIMAFVAIGFQHVVANMFVIPAAIFAG SFTWGQFIGNIIPAFIGNVIGGAVFVGLIYFIAYHKKDRSRKEMKQVS*" /label="yrhG CDS" gene complement(2403786..2404586) /gene="yrhG" /locus_tag="BSU_27200" /old_locus_tag="BSU27200" /label="yrhG gene" S_feature complement(2404655..2404808) /Source="Nicolas_S_feature" /locus_tag="new_2780331_2780484_c" /HighExp="Lbexp, dia0, dia5, Cold, G150, Etha, HiOs, Salt, C90, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1029" downshifts complement(2404698) /Source="Nicolas_upshifts" /id="D1392" /incds=0 /nref=1 /ntot=70 /MaxReadThrough="6.01922" /MaxDrop="3.7673" /score="23.461824" /energy="-25" /TU="U2094,U2095" /idTUdmin="U2095" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2404799..2404818) /Source="Nicolas_upshift_promotors" /id="U2094" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.418581418581419" /psig=1 /xcortree=111 /SigmaFactorBS="aagaagctctgcaaagctagtatatttgtCATTGACacaaat ttgtcacaTTTGATATGATGTTGCTACAgttatagaaggctaaagcaatggaatgtat g" /listShort="S1029, yrhG, S1028, S1027, S1026, yrzI, S1025" /listLong="S1024, S1023, yrhH" /label="promotor_-10" upshifts complement(2404808) /Source="Nicolas_upshifts" /id="U2094" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.418581418581419" /psig=1 /xcortree=111 /SigmaFactorBS="aagaagctctgcaaagctagtatatttgtCATTGACacaaat ttgtcacaTTTGATATGATGTTGCTACAgttatagaaggctaaagcaatggaatgtat g" /listShort="S1029, yrhG, S1028, S1027, S1026, yrzI, S1025" /listLong="S1024, S1023, yrhH" /label="upshifts" promotor_-35 complement(2404833..2404839) /Source="Nicolas_upshift_promotors" /id="U2094" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.418581418581419" /psig=1 /xcortree=111 /SigmaFactorBS="aagaagctctgcaaagctagtatatttgtCATTGACacaaat ttgtcacaTTTGATATGATGTTGCTACAgttatagaaggctaaagcaatggaatgtat g" /listShort="S1029, yrhG, S1028, S1027, S1026, yrzI, S1025" /listLong="S1024, S1023, yrhH" /label="promotor_-35" CDS complement(2404849..2405217) /gene="yrhF" /locus_tag="BSU_27210" /old_locus_tag="BSU27210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390599.1" /db_xref="EnsemblGenomes-Gn:BSU27210" /db_xref="EnsemblGenomes-Tr:CAB14663" /db_xref="InterPro:IPR018745" /db_xref="SubtiList:BG12295" /db_xref="UniProtKB/Swiss-Prot:O05398" /translation="MSKKIHEFNDIIRKLRKELFGKGPERIHTVFVENMAVSTLYGNL SASEQFIARTPEGREMVHAARTSLIQDLYSKQTPEGMEELMGAKLVHLFSDIKIEENI AVSVFVFDRKIDEQKEALQS*" /label="yrhF CDS" gene complement(2404849..2405217) /gene="yrhF" /locus_tag="BSU_27210" /old_locus_tag="BSU27210" /label="yrhF gene" S_feature complement(2405218..2405314) /Source="Nicolas_S_feature" /locus_tag="new_2780894_2780990_c" /HighExp="T0.30H, LBGstat, T1.0H, T1.30H, G150, Lbexp, dia0, G180, M9-stat, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1030" promotor_-10 complement(2405300..2405319) /Source="Nicolas_upshift_promotors" /id="U2095" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=2748 /SigmaFactorBS="atagactcataacaagatcctattacaaatccatcaacactG CTTTtattataatgtgataTTTATTATAATACAATATGGcaggaaaattttaaccaag t" /listShort="S1030, yrhF, S1029" /listLong="yrhG, S1028, S1027, S1026, yrzI, S1025, S1024, S1023, yrhH" /label="promotor_-10" promotor_-35 2405304..2405307 /Source="Nicolas_upshift_promotors" /id="U2096" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.412587412587413" /psig=1 /xcortree=2755 /SigmaFactorBS="ccctcaggacatttcacttggttaaaattttcctgccatATT GtattataataaatatCACATTATAATAAAAGCAGTgttgatggatttgtaataggat c" /listShort="S1031, yrhE, yrhD" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2405320) /Source="Nicolas_upshifts" /id="U2095" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=2748 /SigmaFactorBS="atagactcataacaagatcctattacaaatccatcaacactG CTTTtattataatgtgataTTTATTATAATACAATATGGcaggaaaattttaaccaag t" /listShort="S1030, yrhF, S1029" /listLong="yrhG, S1028, S1027, S1026, yrzI, S1025, S1024, S1023, yrhH" /label="upshifts" promotor_-10 2405323..2405342 /Source="Nicolas_upshift_promotors" /id="U2096" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.412587412587413" /psig=1 /xcortree=2755 /SigmaFactorBS="ccctcaggacatttcacttggttaaaattttcctgccatATT GtattataataaatatCACATTATAATAAAAGCAGTgttgatggatttgtaataggat c" /listShort="S1031, yrhE, yrhD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2405325 /Source="Nicolas_upshifts" /id="U2096" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.412587412587413" /psig=1 /xcortree=2755 /SigmaFactorBS="ccctcaggacatttcacttggttaaaattttcctgccatATT GtattataataaatatCACATTATAATAAAAGCAGTgttgatggatttgtaataggat c" /listShort="S1031, yrhE, yrhD" /GFF_Attribute="listLong" /label="upshifts" S_feature 2405326..2405532 /Source="Nicolas_S_feature" /locus_tag="new_2781002_2781208" /HighExp="G150, Lbexp, dia0, Cold, dia5, G135, LBGstat, LBGexp, G180, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1031" promotor_-35 complement(2405335..2405339) /Source="Nicolas_upshift_promotors" /id="U2095" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=2748 /SigmaFactorBS="atagactcataacaagatcctattacaaatccatcaacactG CTTTtattataatgtgataTTTATTATAATACAATATGGcaggaaaattttaaccaag t" /listShort="S1030, yrhF, S1029" /listLong="yrhG, S1028, S1027, S1026, yrzI, S1025, S1024, S1023, yrhH" /label="promotor_-35" CDS 2405533..2408475 /gene="yrhE" /locus_tag="BSU_27220" /old_locus_tag="BSU27220" /EC_number="1.17.1.9" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10913079, 19114526; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative formate dehydrogenase" /protein_id="NP_390600.1" /db_xref="EnsemblGenomes-Gn:BSU27220" /db_xref="EnsemblGenomes-Tr:CAB14664" /db_xref="GOA:Q795Y4" /db_xref="InterPro:IPR001041" /db_xref="InterPro:IPR006478" /db_xref="InterPro:IPR006656" /db_xref="InterPro:IPR006657" /db_xref="InterPro:IPR006963" /db_xref="InterPro:IPR009010" /db_xref="InterPro:IPR009051" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR017900" /db_xref="InterPro:IPR019574" /db_xref="InterPro:IPR036010" /db_xref="SubtiList:BG12294" /db_xref="UniProtKB/Swiss-Prot:Q795Y4" /translation="MMDVKSISVRVDGTEIQARAGATILDILNENGIEYPQICHVPEV DPIQTCDTCIVEANGKLVRSCATVAENGMSIDLSGNRVKEAQTEAMDRLLENHLLYCT VCDNNNGNCTLHNTAEMMGIEHQKYPYTPKEDPSCAVDMSHPFYRYDPNQCIACGQCV EVCQNLQVNETLSIDWERERPRVIWDEGVPINESSCVSCGQCVTVCPCNALMEKSMLG QAGFMTGIKEDVMEPMIDLVKNVEPGYGSIFAISEVEAAMRETRTKKTKTVCTFCGVG CSFEVWTKGRDILKIQPVSDAPVNAISTCVKGKFGWDFVNSKERITKPLIRKNGAFVE SSWEEALDLVASRLGSIKEQYGKGSVGFISSSKITNEENYVIQKLARQVFETNNVDNC SRYCQSPATDGLFRTVGMGGDAGTIKDIAKAGLVIIVGANPAEGHPVLATRVKRAHKL HGQKLIVADLRKNEMAERSDLFISPKQGTDQVWLMAVTKYMIDQGWHDQAFIDENVNY FEDYKETLKTYTLDYAERITGLSKENIIQIAEMIRDADGTCVLWGMGVTQNTGGSDTS AAISNLLLATGNYRRPGAGAYPLRGHNNVQGACDMGTLPGWLPGYQHITDDKARAKFE EAYGVEIDGKPGLDNIQMLHAIEEGKMKAMYLVGEDMALVDSNANHVHDILSSLDFFV VQDIFLSRTAQYADVVLPATPSLEKDGTFTNTERRVQRLYQALPTLGDAKPDWWIIQE VANRLGANWNYSHPSDIFSEMASLSPLFAKASYEVLEGWNSFLWGSFTGESTPLLYED GFNFPDKKARFALSDWTEPAAFPEEYDLHINNGRMLEHFHEGNMTNKSKGIQAKVPNV FVEISPELAQERGVCDGSLVRLVSPFGAVKLNALITDRVRKNELYLPMNSTDKESAIN FLTGPAADKRTNTPAYKQTKVRMEVLGGCETAPLPKTNPRNKKRHPQNGVEAERKWNR PGYVHLTD*" /label="yrhE CDS" gene 2405533..2408475 /gene="yrhE" /locus_tag="BSU_27220" /old_locus_tag="BSU27220" /label="yrhE gene" CDS 2408494..2408976 /gene="yrhD" /locus_tag="BSU_27230" /old_locus_tag="BSU27230" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 10913079" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390601.1" /db_xref="EnsemblGenomes-Gn:BSU27230" /db_xref="EnsemblGenomes-Tr:CAB14665" /db_xref="InterPro:IPR012440" /db_xref="SubtiList:BG12293" /db_xref="UniProtKB/Swiss-Prot:O05396" /translation="MATPITTIKKETKTAEQIKLEKIEELKELLAENEDAVSKTMTLM NELNDLGIFDAATSMLRAKEDIAKIALGQVSREPVTNLINTMMAAGGALTKADPEFTA KLLESVMAGTEQAQSFLKEDKKVGILDLLKAMNDPDINRAVGFGLQFLKGMGKELREQ *" /label="yrhD CDS" gene 2408494..2408976 /gene="yrhD" /locus_tag="BSU_27230" /old_locus_tag="BSU27230" /label="yrhD gene" downshifts 2408956 /Source="Nicolas_upshifts" /id="D1393" /incds=0 /nref=65 /ntot=196 /MaxReadThrough="1.1227" /MaxDrop="6.19465" /score="27.8496451" /energy="-11.2" /TU="NA" /idTUdmin="U2096" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2409012..2409242) /gene="yrhC" /locus_tag="BSU_27240" /old_locus_tag="BSU27240" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 17056751" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390602.1" /db_xref="EnsemblGenomes-Gn:BSU27240" /db_xref="EnsemblGenomes-Tr:CAB14666" /db_xref="GOA:O05395" /db_xref="InterPro:IPR025418" /db_xref="SubtiList:BG12292" /db_xref="UniProtKB/Swiss-Prot:O05395" /translation="MNKNRMKSLKEDYKHFAFTLLAVSTFLYIGAVLPDQGLTLGQKS TMFLADCVFLAGAFFCADRSLIYKKRLEEADE*" /label="yrhC CDS" gene complement(2409012..2409242) /gene="yrhC" /locus_tag="BSU_27240" /old_locus_tag="BSU27240" /label="yrhC gene" downshifts complement(2409032) /Source="Nicolas_upshifts" /id="D1394" /incds=0 /nref=60 /ntot=210 /MaxReadThrough="0.98344" /MaxDrop="5.84379" /score="15.2557797" /energy="-11.2" /TU="NA" /idTUdmin="U2097" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2409243..2409324) /Source="Nicolas_S_feature" /locus_tag="new_2784919_2785000_c" /HighExp="dia5, dia15, BT, Diami, B36, B60, nit, dia0, MG 10, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA, SigA" /TUshortPSig="1, 0.999, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1032" CDS complement(2409325..2410464) /gene="mccB" /locus_tag="BSU_27250" /old_locus_tag="BSU27250" /EC_number="4.4.1.2" /EC_number="4.4.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 15760717, 17056751, 18812398" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 15760717, 17056751, 18812398; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cystathionine gamma-lyase and homocysteine gamma-lyase for reverse transsulfuration pathway" /protein_id="NP_390603.1" /db_xref="EnsemblGenomes-Gn:BSU27250" /db_xref="EnsemblGenomes-Tr:CAB14667" /db_xref="GOA:O05394" /db_xref="InterPro:IPR000277" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG12291" /db_xref="UniProtKB/Swiss-Prot:O05394" /translation="MKKKTLMIHGGITGDEKTGAVSVPIYQVSTYKQPKAGQHTGYEY SRTANPTRTALEALVTELESGEAGYAFSSGMAAITAVMMLFNSGDHVVLTDDVYGGTY RVMTKVLNRLGIESTFVDTSSREEVEKAIRPNTKAIYIETPTNPLLKITDLTLMADIA KKAGVLLIVDNTFNTPYFQQPLTLGADIVLHSATKYLGGHSDVVGGLVVTASKELGEE LHFVQNSTGGVLGPQDSWLLMRGIKTLGLRMEAIDQNARKIASFLENHPAVQTLYYPG SSNHPGHELAKTQGAGFGGMISFDIGSEERVDAFLGNLKLFTIAESLGAVESLISVPA RMTHASIPRERRLELGITDGLIRISVGIEDAEDLLEDIGQALENI*" /label="mccB CDS" gene complement(2409325..2410464) /gene="mccB" /locus_tag="BSU_27250" /old_locus_tag="BSU27250" /label="mccB gene" CDS complement(2410466..2411389) /gene="mccA" /locus_tag="BSU_27260" /old_locus_tag="BSU27260" /EC_number="2.5.1.47" /EC_number="4.2.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 15760717, 17056751, 18812398" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 15760717, 17056751, 18812398; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cystathionine beta-synthase for the reverse transsulfuration pathway" /protein_id="NP_390604.1" /db_xref="EnsemblGenomes-Gn:BSU27260" /db_xref="EnsemblGenomes-Tr:CAB14668" /db_xref="GOA:O05393" /db_xref="InterPro:IPR001216" /db_xref="InterPro:IPR001926" /db_xref="InterPro:IPR036052" /db_xref="SubtiList:BG12290" /db_xref="UniProtKB/Swiss-Prot:O05393" /translation="MTVITDITELIGNTPLLRLKNFDVPEGVAVYAKLEMMNPGGSIK DRLGDMLIRDALDSGKVKPGGVIIEATAGNTGIGLALSARKYGLKAIFCVPEHFSREK QQIMQALGASIIHTPRQDGMQGAIQKAIQLETEIENSYCVLQFKNRVNPSTYYKTLGP EMWEALDGNIHTFVAGAGSGGTFAGTASFLKEKNPAVKTVIVEPVGSILNGGEPHAHK TEGIGMEFIPDYMDKSHFDEIYTVTDENAFRLVKEAAEKEGLLIGSSSGAALYAALEE AKKASAGTNIVTVFPDSSDRYISKQIYEGGI*" /label="mccA CDS" gene complement(2410466..2411389) /gene="mccA" /locus_tag="BSU_27260" /old_locus_tag="BSU27260" /label="mccA gene" downshifts complement(2411382) /Source="Nicolas_upshifts" /id="D1395" /incds=0 /nref=16 /ntot=178 /MaxReadThrough="7.13056" /MaxDrop="3.40819" /score="0.994445584" /energy="-8.7" /TU="U2097,U2098,U2099" /idTUdmin="U2102" /TUdmin=1874 /isTUend="FALSE" /label="downshifts" S_feature complement(2411390..2411453) /Source="Nicolas_S_feature" /locus_tag="new_2787066_2787129_c" /HighExp="dia5, Diami, dia15, BT, B36, S6, LBGstat, S8, dia0, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA, SigA" /TUshortPSig="1, 0.999, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1033" CDS complement(2411454..2412149) /gene="mtnN" /locus_tag="BSU_27270" /old_locus_tag="BSU27270" /EC_number="3.2.2.9" /EC_number="3.2.2.16" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10574451, 10939241, 15102328, 17056751, 24509311, 25849497, 25849889" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10574451, 10939241, 15102328, 17056751, 24509311, 25849497, 25849889; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylthioadenosine / S-adenosylhomocysteine nucleosidase" /protein_id="NP_390605.1" /db_xref="EnsemblGenomes-Gn:BSU27270" /db_xref="EnsemblGenomes-Tr:CAB14669" /db_xref="GOA:O32028" /db_xref="InterPro:IPR000845" /db_xref="InterPro:IPR010049" /db_xref="InterPro:IPR035994" /db_xref="SubtiList:BG13800" /db_xref="UniProtKB/Swiss-Prot:O32028" /translation="MRLAVIGAMEEEVTILRNKLENAKTETIAHCEFTTGEYEGTEVI LLKSGIGKVNAAISTTLLLDRYKPDYVINTGSAGGFHHTLNVGDVVISTDVRHHDVDV TAFDYEYGQVPGLPAAYAADEKLISITEEAVSELDGIQVAKGTIATGDSFMNDPKRVE EVRARFSDLYAVEMEAAAVAQVCHQFKTPFVVIRALSDIAGKESHVSFDQFLEQAAVH STELVLKVIKRIH*" /label="mtnN CDS" gene complement(2411454..2412149) /gene="mtnN" /locus_tag="BSU_27270" /old_locus_tag="BSU27270" /label="mtnN gene" promotor_-10 complement(2411889..2411908) /Source="Nicolas_upshift_promotors" /id="U2097" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1315 /SigmaFactorBS="tctgcttgaccgttacaagcctgattatgtcattaacACAGG CTCAGccggcggatttcATCATACATTGAATGTAGGGgatgtcgtcatttccactgac g" /listShort="S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2411907) /Source="Nicolas_upshifts" /id="U2097" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1315 /SigmaFactorBS="tctgcttgaccgttacaagcctgattatgtcattaacACAGG CTCAGccggcggatttcATCATACATTGAATGTAGGGgatgtcgtcatttccactgac g" /listShort="S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2411921..2411930) /Source="Nicolas_upshift_promotors" /id="U2097" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1315 /SigmaFactorBS="tctgcttgaccgttacaagcctgattatgtcattaacACAGG CTCAGccggcggatttcATCATACATTGAATGTAGGGgatgtcgtcatttccactgac g" /listShort="S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2412170..2412811) /gene="yrrT" /locus_tag="BSU_27280" /old_locus_tag="BSU27280" /EC_number="2.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10939241, 17056751; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative AdoMet-dependent methyltransferase" /protein_id="NP_390606.1" /db_xref="EnsemblGenomes-Gn:BSU27280" /db_xref="EnsemblGenomes-Tr:CAB14670" /db_xref="GOA:O32029" /db_xref="InterPro:IPR001737" /db_xref="InterPro:IPR020598" /db_xref="InterPro:IPR023553" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG13799" /db_xref="UniProtKB/Swiss-Prot:O32029" /translation="MGREFIPLFEDWAATYDQTVQGLDIQYKEAFRGYDHILDAIVRK SGTHVLEFGPGTGNLTAKLLDAGKTVFGIEPSPAMRKLASDKLSGRTEIVDGDFLTFP EPPFQADTIVSSYAFHHLTDEEKRAAIKQYGKYLHLHDKIVFADTVFENAQAYQQAID KARSQGFYQLANDLETEHYPTLDALKEMFTAEGFAVRFTQQNDFVWIMEAIKR*" /label="yrrT CDS" gene complement(2412170..2412811) /gene="yrrT" /locus_tag="BSU_27280" /old_locus_tag="BSU27280" /label="yrrT gene" promotor_-10 complement(2412378..2412397) /Source="Nicolas_upshift_promotors" /id="U2098" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=2663 /SigmaFactorBS="catttgactgacgaagaaaagcgggctgccataaagcaatAT GGcaaataccttcacttgCATGATAAAATAGTGTTTGCcgataccgtctttgaaaatg c" /listShort="mtnN, S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2412397) /Source="Nicolas_upshifts" /id="U2098" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=2663 /SigmaFactorBS="catttgactgacgaagaaaagcgggctgccataaagcaatAT GGcaaataccttcacttgCATGATAAAATAGTGTTTGCcgataccgtctttgaaaatg c" /listShort="mtnN, S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2412414..2412417) /Source="Nicolas_upshift_promotors" /id="U2098" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=2663 /SigmaFactorBS="catttgactgacgaagaaaagcgggctgccataaagcaatAT GGcaaataccttcacttgCATGATAAAATAGTGTTTGCcgataccgtctttgaaaatg c" /listShort="mtnN, S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2412863..2412872 /Source="Nicolas_upshift_promotors" /id="U2100" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=1274 /SigmaFactorBS="taattcctataagtatactatggattaatGATGGAACAGttc ctataatacCACATATTCTGAAAAGCAGGtactaaaacactttgtgtattttatgcca t" /listShort="S1034, yrzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2412869..2412888) /Source="Nicolas_upshift_promotors" /id="U2099" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.436563436563437" /psig="0.998001998001998" /xcortree=1746 /SigmaFactorBS="gatggcataaaatacacaaagtgttttaGTACctgcttttca gaataTGTGGTATTATAGGAACTGTtccatcattaatccatagtatacttataggaat t" /listShort="yrrT, mtnN, S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2412875) /Source="Nicolas_upshifts" /id="U2099" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.436563436563437" /psig="0.998001998001998" /xcortree=1746 /SigmaFactorBS="gatggcataaaatacacaaagtgttttaGTACctgcttttca gaataTGTGGTATTATAGGAACTGTtccatcattaatccatagtatacttataggaat t" /listShort="yrrT, mtnN, S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2412885..2412904 /Source="Nicolas_upshift_promotors" /id="U2100" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=1274 /SigmaFactorBS="taattcctataagtatactatggattaatGATGGAACAGttc ctataatacCACATATTCTGAAAAGCAGGtactaaaacactttgtgtattttatgcca t" /listShort="S1034, yrzA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2412894..2412958 /Source="Nicolas_S_feature" /locus_tag="new_2788570_2788634" /HighExp="BT, S6, S7, S8, S5, B36, G/S, Pyr, C30, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.975" /TUlongSig="NA" /TUlongPSig="NA" /label="S1034" upshifts 2412894 /Source="Nicolas_upshifts" /id="U2100" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=1274 /SigmaFactorBS="taattcctataagtatactatggattaatGATGGAACAGttc ctataatacCACATATTCTGAAAAGCAGGtactaaaacactttgtgtattttatgcca t" /listShort="S1034, yrzA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2412904..2412907) /Source="Nicolas_upshift_promotors" /id="U2099" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.436563436563437" /psig="0.998001998001998" /xcortree=1746 /SigmaFactorBS="gatggcataaaatacacaaagtgttttaGTACctgcttttca gaataTGTGGTATTATAGGAACTGTtccatcattaatccatagtatacttataggaat t" /listShort="yrrT, mtnN, S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2412939..2412946 /Source="Nicolas_upshift_promotors" /id="U2101" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.471528471528472" /psig="0.837162837162837" /xcortree=2723 /SigmaFactorBS="gcaggtactaaaacactttgtgtattttatgccatctcaTAT TGCGCattgaccgcaaaaaaGCTTATACTTCATATGACttgtgaaagctggagggtca a" /listShort="yrzA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2412960 /Source="Nicolas_upshifts" /id="U2101" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.471528471528472" /psig="0.837162837162837" /xcortree=2723 /SigmaFactorBS="gcaggtactaaaacactttgtgtattttatgccatctcaTAT TGCGCattgaccgcaaaaaaGCTTATACTTCATATGACttgtgaaagctggagggtca a" /listShort="yrzA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2412962..2412979 /Source="Nicolas_upshift_promotors" /id="U2101" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.471528471528472" /psig="0.837162837162837" /xcortree=2723 /SigmaFactorBS="gcaggtactaaaacactttgtgtattttatgccatctcaTAT TGCGCattgaccgcaaaaaaGCTTATACTTCATATGACttgtgaaagctggagggtca a" /listShort="yrzA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2413004..2413207 /gene="yrzA" /locus_tag="BSU_27290" /old_locus_tag="BSU27290" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390607.1" /db_xref="EnsemblGenomes-Gn:BSU27290" /db_xref="EnsemblGenomes-Tr:CAB14671" /db_xref="InterPro:IPR019686" /db_xref="SubtiList:BG13811" /db_xref="UniProtKB/Swiss-Prot:O32030" /translation="MNFQLDLIKDKVEFFEAASLQELEKKINTQIENNKAIMLRVKSV SHQTLVAEGRILYSAVVHFSAEA*" /label="yrzA CDS" gene 2413004..2413207 /gene="yrzA" /locus_tag="BSU_27290" /old_locus_tag="BSU27290" /label="yrzA gene" downshifts 2413214 /Source="Nicolas_upshifts" /id="D1396" /incds=0 /nref=205 /ntot=257 /MaxReadThrough="1.11529" /MaxDrop="5.39095" /score="26.0850303" /energy="-14.2" /TU="NA" /idTUdmin="U2101" /TUdmin="-10" /isTUend="TRUE" /label="downshifts" CDS complement(2413244..2413945) /gene="yrrS" /locus_tag="BSU_27300" /old_locus_tag="BSU27300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 14679248" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_390608.1" /db_xref="EnsemblGenomes-Gn:BSU27300" /db_xref="EnsemblGenomes-Tr:CAB14672" /db_xref="GOA:O32031" /db_xref="InterPro:IPR009988" /db_xref="SubtiList:BG13798" /db_xref="UniProtKB/Swiss-Prot:O32031" /translation="MSNNQSRYENRDKRRKANLVLNILIAIVSILIVVVAANLFINSP SSKDVSKDSETAQKQESPASGKTEKKSDEDIKDSKKDTSDSEKDSEKSSDSDSKKDDS SSKKDDSDSDSSSDSAGDGLKDAKVTEGGSSSDVEKTYENPDWKAVGTEQTGEHAATY DSSSQDWAEMLKAISYATGVSTDNMTVLWLGNNGSPQDAKGKILDKATGNKYQVTITW VDEKGWKPTKVEKLK*" /label="yrrS CDS" gene complement(2413244..2413945) /gene="yrrS" /locus_tag="BSU_27300" /old_locus_tag="BSU27300" /label="yrrS gene" downshifts complement(2413256) /Source="Nicolas_upshifts" /id="D1397" /incds=0 /nref=237 /ntot=265 /MaxReadThrough="1.64695" /MaxDrop="6.48551" /score="22.1367505" /energy="-14.2" /TU="NA" /idTUdmin="U2102" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2414010..2415764) /gene="pbpI" /locus_tag="BSU_27310" /old_locus_tag="BSU27310" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:14679248" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14679248; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="penicillin-binding protein PBP4B" /protein_id="NP_390609.1" /db_xref="EnsemblGenomes-Gn:BSU27310" /db_xref="EnsemblGenomes-Tr:CAB14673" /db_xref="GOA:O32032" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR005311" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR036138" /db_xref="SubtiList:BG13797" /db_xref="UniProtKB/Swiss-Prot:O32032" /translation="MKISKRMKLAVIAFLIVFFLLLLRLAEIQLFFTESFSKKKINLI QESVKQRTEEVLISDGRGSFLDRNGRALTGQSEPAVVLFPFLLTQDWPIKKVADILGM SEDDLRQTLGQAKKPVILQQKKIKTLSKQSITKINSLKYPGIYGVYMENEDKPSLASH TIGSTNQDPALLRKKYPDKESLPITTEIGTTGLERTFDEFLLPEQDTKLLYHVDGKGN PLFGMDVKYTAEANTFYPLQIKTTIDQSIQKAMEEVLDEQGLKKGGAVLLDIENSSVL GIVSKPDADVSRQNTLQNYMLTPIYPGSVFKTVIAAAAIENNMVKPSQTFNCNLNLYG EPGDDKGTLSFDESFAQSCNYTFTSLAEQLMKKDSSVIEDMSEKLALTDRAGWEGKLY HETDFRQLYNEKSGVIWGDEKDKSVKKAIAQTAIGQKNVKVTPLEVANMMATIARGGE KRQVKIAEQIEYKNGTTLVTFKDQKLKGETIDKYTSQQLQKILRRVVESPSGTGRRFQ DLPYTVAGKSGTAQTGKLSKEKETLYEKWFAGYFPADKPKYALVVLHMDTPGDKALTN SVFYDIVKKVHEIEINQK*" /label="pbpI CDS" gene complement(2414010..2415764) /gene="pbpI" /locus_tag="BSU_27310" /old_locus_tag="BSU27310" /label="pbpI gene" misc_feature complement(2414038..2414057) /Source="Nicolas_upshift_promotors" /id="U2102" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.938061938061938" /psig="0.998001998001998" /xcortree=2157 /SigmaFactorBS="gttttacacatggatacaccgggagataaggctctgacaaat tcggtgtttTATGATATTGTTAAAAAAGTacacgaaattgaaatcaatcagaaataga a" /listShort="yrrS" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2414048) /Source="Nicolas_upshifts" /id="U2102" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.938061938061938" /psig="0.998001998001998" /xcortree=2157 /SigmaFactorBS="gttttacacatggatacaccgggagataaggctctgacaaat tcggtgtttTATGATATTGTTAAAAAAGTacacgaaattgaaatcaatcagaaataga a" /listShort="yrrS" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2415079..2415094) /Source="Nicolas_upshift_promotors" /id="U2103" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1643 /SigmaFactorBS="agcttttatatcatgtggacggaaaaGGAAACCCTTtgtttg gcatggACGTCAAATATACAGCtgaagccaatacattttatccgctccagatcaaaac a" /listShort="yrrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2415082) /Source="Nicolas_upshifts" /id="U2103" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1643 /SigmaFactorBS="agcttttatatcatgtggacggaaaaGGAAACCCTTtgtttg gcatggACGTCAAATATACAGCtgaagccaatacattttatccgctccagatcaaaac a" /listShort="yrrS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2415107..2415116) /Source="Nicolas_upshift_promotors" /id="U2103" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1643 /SigmaFactorBS="agcttttatatcatgtggacggaaaaGGAAACCCTTtgtttg gcatggACGTCAAATATACAGCtgaagccaatacattttatccgctccagatcaaaac a" /listShort="yrrS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2415310..2415328) /Source="Nicolas_upshift_promotors" /id="U2104" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96103896103896" /psig="0.96103896103896" /xcortree=975 /SigmaFactorBS="actttcaaaacaatctatcacaaaaatcaattctttGAAATA tcccggcatttacgGCGTATATATGGAGAATGAagacaagcccagccttgcttcacat a" /listShort="yrrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2415324) /Source="Nicolas_upshifts" /id="U2104" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96103896103896" /psig="0.96103896103896" /xcortree=975 /SigmaFactorBS="actttcaaaacaatctatcacaaaaatcaattctttGAAATA tcccggcatttacgGCGTATATATGGAGAATGAagacaagcccagccttgcttcacat a" /listShort="yrrS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2415343..2415350 /Source="Nicolas_upshift_promotors" /id="U2105" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.805194805194805" /psig=1 /xcortree=3003 /SigmaFactorBS="tcattctccatatatacgccgtaaatgccgggaTATTTCAAa gaattgatttttgTGATAGATTGTTTTGAAAGTgttttgattttcttttgctgcaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2415343..2415348) /Source="Nicolas_upshift_promotors" /id="U2104" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96103896103896" /psig="0.96103896103896" /xcortree=975 /SigmaFactorBS="actttcaaaacaatctatcacaaaaatcaattctttGAAATA tcccggcatttacgGCGTATATATGGAGAATGAagacaagcccagccttgcttcacat a" /listShort="yrrS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2415365..2415384 /Source="Nicolas_upshift_promotors" /id="U2105" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.805194805194805" /psig=1 /xcortree=3003 /SigmaFactorBS="tcattctccatatatacgccgtaaatgccgggaTATTTCAAa gaattgatttttgTGATAGATTGTTTTGAAAGTgttttgattttcttttgctgcaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2415370 /Source="Nicolas_upshifts" /id="U2105" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.805194805194805" /psig=1 /xcortree=3003 /SigmaFactorBS="tcattctccatatatacgccgtaaatgccgggaTATTTCAAa gaattgatttttgTGATAGATTGTTTTGAAAGTgttttgattttcttttgctgcaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2415818..2416291) /gene="greA" /locus_tag="BSU_27320" /old_locus_tag="BSU27320" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10910724, 16014871, 16707701, 21515770, 28976965" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10910724, 16014871, 16707701, 21515770, 28976965; Product type f: factor" /codon_start=1 /transl_table=11 /product="transcription elongation factor resolving backtracking / stalling" /protein_id="NP_390610.1" /db_xref="EnsemblGenomes-Gn:BSU27320" /db_xref="EnsemblGenomes-Tr:CAB14674" /db_xref="GOA:P80240" /db_xref="InterPro:IPR001437" /db_xref="InterPro:IPR006359" /db_xref="InterPro:IPR018151" /db_xref="InterPro:IPR022691" /db_xref="InterPro:IPR023459" /db_xref="InterPro:IPR028624" /db_xref="InterPro:IPR036805" /db_xref="InterPro:IPR036953" /db_xref="SubtiList:BG19019" /db_xref="UniProtKB/Swiss-Prot:P80240" /translation="MAQEKVFPMTAEGKQKLEQELEYLKTVKRKEVVERIKIARSFGD LSENSEYDSAKEEQAFVEGRVTTLENMIRNAKIIEDDGGSNVVGLGKTVTFVELPDGD EESYTIVGSAEADPFEGKISNDSPIAKSLLGKKVDEEVTVQTPGGEMLVKIVKIS*" /label="greA CDS" gene complement(2415818..2416291) /gene="greA" /locus_tag="BSU_27320" /old_locus_tag="BSU27320" /label="greA gene" downshifts complement(2415825) /Source="Nicolas_upshifts" /id="D1398" /incds=0 /nref=130 /ntot=229 /MaxReadThrough="5.30316" /MaxDrop="4.90519" /score="34.2316821" /energy="-17" /TU="U2107" /idTUdmin="U2106" /TUdmin="-17" /isTUend="TRUE" /label="downshifts" S_feature complement(2416292..2416424) /Source="Nicolas_S_feature" /locus_tag="new_2791968_2792100_c" /HighExp="HPh, C90, dia5, dia15, Diami, H2O2, dia0, Etha, G180, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="0.998, 1, 1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1035" promotor_-10 complement(2416406..2416425) /Source="Nicolas_upshift_promotors" /id="U2106" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.839160839160839" /psig="0.998001998001998" /xcortree=1924 /SigmaFactorBS="gtgcgaattcccttctttccctgtttataaacgcgaaaTATT TGCAgaacgacacgattCAGTTTAAGATAAACAGTACctatatgggagagaagaacga g" /listShort="S1035, greA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2416424) /Source="Nicolas_upshifts" /id="U2106" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.839160839160839" /psig="0.998001998001998" /xcortree=1924 /SigmaFactorBS="gtgcgaattcccttctttccctgtttataaacgcgaaaTATT TGCAgaacgacacgattCAGTTTAAGATAAACAGTACctatatgggagagaagaacga g" /listShort="S1035, greA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2416426..2416534) /Source="Nicolas_S_feature" /locus_tag="new_2792102_2792210_c" /HighExp="HPh, G180, G135, LBGexp, dia0, Paraq, Oxctl, G150, LPh, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1036" promotor_-35 complement(2416439..2416446) /Source="Nicolas_upshift_promotors" /id="U2106" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.839160839160839" /psig="0.998001998001998" /xcortree=1924 /SigmaFactorBS="gtgcgaattcccttctttccctgtttataaacgcgaaaTATT TGCAgaacgacacgattCAGTTTAAGATAAACAGTACctatatgggagagaagaacga g" /listShort="S1035, greA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2416527..2416546) /Source="Nicolas_upshift_promotors" /id="U2107" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.656343656343656" /psig=1 /xcortree=2659 /SigmaFactorBS="atctgatggtcacaaaaattcaaaccatTCTTGaacaaaacg cgatttTGTAATACCATAGCATAGACataaataactctgaccatattatgtataggca g" /listShort="S1036, S1035, greA, pbpI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2416534) /Source="Nicolas_upshifts" /id="U2107" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.656343656343656" /psig=1 /xcortree=2659 /SigmaFactorBS="atctgatggtcacaaaaattcaaaccatTCTTGaacaaaacg cgatttTGTAATACCATAGCATAGACataaataactctgaccatattatgtataggca g" /listShort="S1036, S1035, greA, pbpI" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2416542..2417177) /gene="udk" /locus_tag="BSU_27330" /old_locus_tag="BSU27330" /EC_number="2.7.1.48" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 6208029; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="uridine kinase" /protein_id="NP_390611.1" /db_xref="EnsemblGenomes-Gn:BSU27330" /db_xref="EnsemblGenomes-Tr:CAB14675" /db_xref="GOA:O32033" /db_xref="InterPro:IPR000764" /db_xref="InterPro:IPR006083" /db_xref="InterPro:IPR026008" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12696" /db_xref="UniProtKB/Swiss-Prot:O32033" /translation="MGKNPVVIGIAGGSGSGKTSVTRSIYEQFKGHSILMIQQDLYYK DQSHLPFEERLNTNYDHPLAFDNDYLIEHIQDLLNYRPIEKPIYDYKLHTRSEETVHV EPKDVIILEGILVLEDKRLRDLMDIKLYVDTDADLRIIRRIMRDINERGRSIDSVIEQ YVSVVRPMHNQFVEPTKRYADIIIPEGGQNHVAIDLMVTKIQTILEQNAIL*" /label="udk CDS" gene complement(2416542..2417177) /gene="udk" /locus_tag="BSU_27330" /old_locus_tag="BSU27330" /label="udk gene" promotor_-35 complement(2416562..2416566) /Source="Nicolas_upshift_promotors" /id="U2107" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.656343656343656" /psig=1 /xcortree=2659 /SigmaFactorBS="atctgatggtcacaaaaattcaaaccatTCTTGaacaaaacg cgatttTGTAATACCATAGCATAGACataaataactctgaccatattatgtataggca g" /listShort="S1036, S1035, greA, pbpI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2416672..2416677 /Source="Nicolas_upshift_promotors" /id="U2108" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.865134865134865" /psig="0.865134865134865" /xcortree=1199 /SigmaFactorBS="cgtatcgtttcgtcggctcgacgaattggttaTGCATCggac ggaccactgacACATATTGTTCAATGACAGaatcaatagagcgtccgcgctcattaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2416693..2416711 /Source="Nicolas_upshift_promotors" /id="U2108" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.865134865134865" /psig="0.865134865134865" /xcortree=1199 /SigmaFactorBS="cgtatcgtttcgtcggctcgacgaattggttaTGCATCggac ggaccactgacACATATTGTTCAATGACAGaatcaatagagcgtccgcgctcattaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2416700 /Source="Nicolas_upshifts" /id="U2108" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.865134865134865" /psig="0.865134865134865" /xcortree=1199 /SigmaFactorBS="cgtatcgtttcgtcggctcgacgaattggttaTGCATCggac ggaccactgacACATATTGTTCAATGACAGaatcaatagagcgtccgcgctcattaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2417184..2418452) /gene="yrrO" /locus_tag="BSU_27340" /old_locus_tag="BSU27340" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase large subunit" /protein_id="NP_390612.1" /db_xref="EnsemblGenomes-Gn:BSU27340" /db_xref="EnsemblGenomes-Tr:CAB14676" /db_xref="GOA:O32034" /db_xref="InterPro:IPR001539" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR032525" /db_xref="SubtiList:BG13796" /db_xref="UniProtKB/Swiss-Prot:O32034" /translation="MTAVNDKISTIVNGKRVITKKPELLAPAGNLEKLKIAVHYGADA VFIGGQEYGLRSNADNFTIEEIAEGVEFAKKYGAKIYVTTNIFAHNENMDGLEDYLKA LGDANVAGIIVADPLIIETCRRVAPNVEVHLSTQQSLSNWKAVQFWKEEGLDRVVLAR ETSALEIREMKEKVDIEIESFIHGAMCIAYSGRCVLSNHMTARDSNRGGCCQSCRWDY DLYQTDGANAVALYGEEDAPFAMSPKDLKLIESIPKMIEMGIDSLKIEGRMKSIHYVA TVVSVYRKVIDAYCADPENFVIQKEWLEELDKCANRDTATAFFEGTPGYEEQMFGEHA KKTTYDFVGLVLNYDEDTQMVTLQQRNFFKKGDEVEFFGPEIENFTHTIETIWDEDGN ELDAARHPLQIVKFKLDKKIYPSNMMRKGK*" /label="yrrO CDS" gene complement(2417184..2418452) /gene="yrrO" /locus_tag="BSU_27340" /old_locus_tag="BSU27340" /label="yrrO gene" CDS complement(2418471..2419400) /gene="yrrN" /locus_tag="BSU_27350" /old_locus_tag="BSU27350" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase small subunit" /protein_id="NP_390613.1" /db_xref="EnsemblGenomes-Gn:BSU27350" /db_xref="EnsemblGenomes-Tr:CAB14677" /db_xref="GOA:O32035" /db_xref="InterPro:IPR001539" /db_xref="InterPro:IPR013785" /db_xref="SubtiList:BG13795" /db_xref="UniProtKB/Swiss-Prot:O32035" /translation="MKKPELLVTPTSTADILPLIQAGATAFLVGEQRYGLRLAGEFSR EDVTKAVEIAHKEGAKVYVAVNAIFHNDKVGELGEYLAFLAEAGVDAAVFGDPAVLMA ARESAPDLKLHWSTETTGTNYYTCNYWGRKGAARSVLARELNMDSIVEIKENAEVEIE IQVHGMTCMFQSKRSLIGNYFEYQGKVMDIERKKKESGMFLHDKERDNKYPIFEDENG THIMSPNDVCIIDELEELIDAGIDSFKIDGVLKMPEYLIEVTKMYREAIDLCVENRDE YEAKKEDWIERIESIQPVNRKIDTGFFFKETVY*" /label="yrrN CDS" gene complement(2418471..2419400) /gene="yrrN" /locus_tag="BSU_27350" /old_locus_tag="BSU27350" /label="yrrN gene" CDS complement(2419406..2420059) /gene="yrrM" /locus_tag="BSU_27360" /old_locus_tag="BSU27360" /EC_number="2.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyl-CoA O-methyltransferase" /protein_id="NP_390614.1" /db_xref="EnsemblGenomes-Gn:BSU27360" /db_xref="EnsemblGenomes-Tr:CAB14678" /db_xref="GOA:O32036" /db_xref="InterPro:IPR002935" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG13794" /db_xref="UniProtKB/Swiss-Prot:O32036" /translation="MTDRYEQINDYIEALLKPRPDNVKRLEAYAEEHHVPIMEKAGME VLLQILSVKQPKKILEIGTAIGYSAIRMALELPSAEIYTIERNEKRHEEAVNNIKEFQ LDDRIHVFYGDALELADAVHVTAPYDVIFIDAAKGQYQNFFHLYEPMLSPDGVIITDN VLFKGLVAEDYSKIEPKRRRRLVAKIDEYNHWLMNHPDYQTAIIPVGDGLAISKKKR* " /label="yrrM CDS" gene complement(2419406..2420059) /gene="yrrM" /locus_tag="BSU_27360" /old_locus_tag="BSU27360" /label="yrrM gene" S_feature complement(2420060..2420164) /Source="Nicolas_S_feature" /locus_tag="new_2795736_2795840_c" /HighExp="LBGexp, G180, H2O2, G150, Paraq, Oxctl, G135, dia15, C30, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1037" promotor_-10 complement(2420146..2420165) /Source="Nicolas_upshift_promotors" /id="U2109" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=2599 /SigmaFactorBS="aaaatgagaaataaaaggagagcaaaaagctctccttttGTT CGctttccgcaaggtttTATGATAAAATATATCGGGTtgtttaccgatgtatcatgat g" /listShort="S1037, yrrM, yrrN, yrrO, udk, S1036, S1035, greA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2420164) /Source="Nicolas_upshifts" /id="U2109" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=2599 /SigmaFactorBS="aaaatgagaaataaaaggagagcaaaaagctctccttttGTT CGctttccgcaaggtttTATGATAAAATATATCGGGTtgtttaccgatgtatcatgat g" /listShort="S1037, yrrM, yrrN, yrrO, udk, S1036, S1035, greA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2420181..2420185) /Source="Nicolas_upshift_promotors" /id="U2109" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=2599 /SigmaFactorBS="aaaatgagaaataaaaggagagcaaaaagctctccttttGTT CGctttccgcaaggtttTATGATAAAATATATCGGGTtgtttaccgatgtatcatgat g" /listShort="S1037, yrrM, yrrN, yrrO, udk, S1036, S1035, greA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2420211..2421293) /gene="yrrL" /locus_tag="BSU_27370" /old_locus_tag="BSU27370" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191" /codon_start=1 /transl_table=11 /product="conserved membrane associated protein" /protein_id="NP_390615.1" /db_xref="EnsemblGenomes-Gn:BSU27370" /db_xref="EnsemblGenomes-Tr:CAB14679" /db_xref="GOA:O34758" /db_xref="InterPro:IPR003770" /db_xref="SubtiList:BG13793" /db_xref="UniProtKB/Swiss-Prot:O34758" /translation="MYINQQKKSFFNKKRIILSSIVVLFLIIGGAFLYGKSLLEPVEK DSKTTVNINIPSGSSVSAIASILKKNDVIKSEKAFQYYVKYKGASGFQAGFYHLNKGM DLDAIIQKLTSGATGYAFQITVTEGAQLTQIAAAIADETKYSKKQVIAKLDDETFINQ LKKEFPDTVTNDVFNKNIKHPLEGYLFPATYPFNDPDTSLEDIIKAMIKQTNSYVETY KSEMKKNKVSVHKLLTMASLIEEEATEKADRHKIASVFYNRLKKKMPLQTDPTVLYAA GKHKDRVLYKDLEIDSPYNTYKNTGLTPGPIANAGMSSWEAALHPDKTDYLYFLAKSN GEVVFTKTLKEHNKAKEKYISSKNEK*" /label="yrrL CDS" gene complement(2420211..2421293) /gene="yrrL" /locus_tag="BSU_27370" /old_locus_tag="BSU27370" /label="yrrL gene" downshifts complement(2420245) /Source="Nicolas_upshifts" /id="D1399" /incds=0 /nref=21 /ntot=144 /MaxReadThrough="3.5258" /MaxDrop="3.97301" /score="10.5327118" /energy="-11" /TU="U2110" /idTUdmin="U2111" /TUdmin=1173 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2421309..2421328) /Source="Nicolas_upshift_promotors" /id="U2110" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=2524 /SigmaFactorBS="ctccggcttttttctgctttatgcaggcctctttttgtaata aATTGccgaaatacaatgaATCATGTAGTATAAGAGCTGatgggaggagacctaatgt a" /listShort="yrrL, S1037, yrrM, yrrN, yrrO, udk, S1036, S1035, greA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2421329) /Source="Nicolas_upshifts" /id="U2110" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=2524 /SigmaFactorBS="ctccggcttttttctgctttatgcaggcctctttttgtaata aATTGccgaaatacaatgaATCATGTAGTATAAGAGCTGatgggaggagacctaatgt a" /listShort="yrrL, S1037, yrrM, yrrN, yrrO, udk, S1036, S1035, greA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2421343..2421346) /Source="Nicolas_upshift_promotors" /id="U2110" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=2524 /SigmaFactorBS="ctccggcttttttctgctttatgcaggcctctttttgtaata aATTGccgaaatacaatgaATCATGTAGTATAAGAGCTGatgggaggagacctaatgt a" /listShort="yrrL, S1037, yrrM, yrrN, yrrO, udk, S1036, S1035, greA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2421419) /Source="Nicolas_upshifts" /id="D1400" /incds=0 /nref=260 /ntot=268 /MaxReadThrough="2.55298" /MaxDrop="6.9121" /score="36.0941054" /energy="-15" /TU="NA" /idTUdmin="U2111" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2421424..2421705) /gene="yrzB" /locus_tag="BSU_27380" /old_locus_tag="BSU27380" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative nucleic acid binding protein" /protein_id="NP_390616.1" /db_xref="EnsemblGenomes-Gn:BSU27380" /db_xref="EnsemblGenomes-Tr:CAB14680" /db_xref="InterPro:IPR009711" /db_xref="SubtiList:BG13812" /db_xref="UniProtKB/Swiss-Prot:O34828" /translation="MEHGEKNITIVDDQGNEQLCEVLFTFENEEFGKSYVLYYPIESK DDEEVEILASSFTPNEDGENGELFPIETDEEWDMIEETLNTFLADEDEE*" /label="yrzB CDS" gene complement(2421424..2421705) /gene="yrzB" /locus_tag="BSU_27380" /old_locus_tag="BSU27380" /label="yrzB gene" downshifts complement(2421484) /Source="Nicolas_upshifts" /id="D1401" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="6.68915" /MaxDrop="5.19246" /score="36.0941054" /energy="-15" /TU="U2111,U2113,U2114,U2115" /idTUdmin="U2111" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" CDS complement(2421723..2422139) /gene="rimF" /locus_tag="BSU_27390" /old_locus_tag="BSU27390" /function="16.6: Maintain" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15044829, 14512736, 16021622, 22720735, 23251031, 25545592; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="pre-16S ribosomal RNA maturation enzyme" /protein_id="NP_390617.1" /db_xref="EnsemblGenomes-Gn:BSU27390" /db_xref="EnsemblGenomes-Tr:CAB14681" /db_xref="GOA:O34634" /db_xref="InterPro:IPR005227" /db_xref="InterPro:IPR006641" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR037027" /db_xref="PDB:1VHX" /db_xref="SubtiList:BG13792" /db_xref="UniProtKB/Swiss-Prot:O34634" /translation="MRILGLDLGTKTLGVALSDEMGWTAQGIETIKINEAEGDYGLSR LSELIKDYTIDKIVLGFPKNMNGTVGPRGEASQTFAKVLETTYNVPVVLWDERLTTMA AEKMLIAADVSRQKRKKVIDKMAAVMILQGYLDSLN*" /label="rimF CDS" gene complement(2421723..2422139) /gene="rimF" /locus_tag="BSU_27390" /old_locus_tag="BSU27390" /label="rimF gene" promotor_-10 complement(2421971..2421989) /Source="Nicolas_upshift_promotors" /id="U2111" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.54045954045954" /psig="0.54045954045954" /xcortree=676 /SigmaFactorBS="cataaagataaatgaagcagaaggcgattatggtttatccCG TTTAtctgaactgataaagGACTATACTATAGATAAAAtcgtgctcggctttcctaag a" /listShort="yrzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2421990) /Source="Nicolas_upshifts" /id="U2111" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.54045954045954" /psig="0.54045954045954" /xcortree=676 /SigmaFactorBS="cataaagataaatgaagcagaaggcgattatggtttatccCG TTTAtctgaactgataaagGACTATACTATAGATAAAAtcgtgctcggctttcctaag a" /listShort="yrzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2422005..2422010) /Source="Nicolas_upshift_promotors" /id="U2111" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.54045954045954" /psig="0.54045954045954" /xcortree=676 /SigmaFactorBS="cataaagataaatgaagcagaaggcgattatggtttatccCG TTTAtctgaactgataaagGACTATACTATAGATAAAAtcgtgctcggctttcctaag a" /listShort="yrzB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2422147..2422413) /gene="yrzL" /locus_tag="BSU_27400" /old_locus_tag="BSU27400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22333191, 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_054589.1" /db_xref="EnsemblGenomes-Gn:BSU27400" /db_xref="EnsemblGenomes-Tr:CAE01464" /db_xref="InterPro:IPR009309" /db_xref="SubtiList:BG14184" /db_xref="UniProtKB/Swiss-Prot:Q7WY61" /translation="MSSFDKTMKFNFSDDSAETNVNEVLITVYDALQEKGYNPINQIV GYLLSGDPAYIPRHRDARNLIRKLERDELIEELVKSYLEQHKEA*" /label="yrzL CDS" gene complement(2422147..2422413) /gene="yrzL" /locus_tag="BSU_27400" /old_locus_tag="BSU27400" /label="yrzL gene" promotor_-35 2422301..2422309 /Source="Nicolas_upshift_promotors" /id="U2112" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1251 /SigmaFactorBS="gcaagtatccgacaatctggttgattggaTTGTAGCCCtttt cctgaagcgcGTCATACACTGTAATCAGCAcctcatttacgttagtctcagcagaatc a" /listShort="S1038" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2422324..2422343 /Source="Nicolas_upshift_promotors" /id="U2112" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1251 /SigmaFactorBS="gcaagtatccgacaatctggttgattggaTTGTAGCCCtttt cctgaagcgcGTCATACACTGTAATCAGCAcctcatttacgttagtctcagcagaatc a" /listShort="S1038" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2422332..2423521 /Source="Nicolas_S_feature" /locus_tag="new_2798008_2799197" /HighExp="S6, C30, C90, S8, S7, Gly, G135, Fru, G180, M/G" /AntisenseName="alaS" /AntisenseCor="-0.27843994691040502" /AntisenseRegPval="-5.5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S1038" upshifts 2422332 /Source="Nicolas_upshifts" /id="U2112" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1251 /SigmaFactorBS="gcaagtatccgacaatctggttgattggaTTGTAGCCCtttt cctgaagcgcGTCATACACTGTAATCAGCAcctcatttacgttagtctcagcagaatc a" /listShort="S1038" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2422414..2422474) /Source="Nicolas_S_feature" /locus_tag="new_2798090_2798150_c" /HighExp="LBGtran, LBGexp, G135, C90, G150, G180, LBGstat, Oxctl, LoTm, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD, SigA" /TUshortPSig="0.994, 0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1039" promotor_-10 complement(2422468..2422487) /Source="Nicolas_upshift_promotors" /id="U2113" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.57042957042957" /psig="0.994005994005994" /xcortree=3173 /SigmaFactorBS="ggcttctgtagaagattgggtgaaatCCGTTTTAtaattcgc ccatgTAGTGTAGAATGATGGTAAGattaggaccccaggctgaactttgcctgcgaat t" /listShort="S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2422474) /Source="Nicolas_upshifts" /id="U2113" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.57042957042957" /psig="0.994005994005994" /xcortree=3173 /SigmaFactorBS="ggcttctgtagaagattgggtgaaatCCGTTTTAtaattcgc ccatgTAGTGTAGAATGATGGTAAGattaggaccccaggctgaactttgcctgcgaat t" /listShort="S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2422498..2425134) /gene="alaS" /locus_tag="BSU_27410" /old_locus_tag="BSU27410" /EC_number="6.1.1.7" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12554667, 12682299, 17329819, 22720735, 25918376; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alanyl-tRNA synthetase" /protein_id="NP_390618.1" /db_xref="EnsemblGenomes-Gn:BSU27410" /db_xref="EnsemblGenomes-Tr:CAB14682" /db_xref="GOA:O34526" /db_xref="InterPro:IPR002318" /db_xref="InterPro:IPR003156" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR012947" /db_xref="InterPro:IPR018162" /db_xref="InterPro:IPR018163" /db_xref="InterPro:IPR018164" /db_xref="InterPro:IPR018165" /db_xref="InterPro:IPR023033" /db_xref="SubtiList:BG12563" /db_xref="UniProtKB/Swiss-Prot:O34526" /translation="MKHLTSAEVRQMFLDFFKEKGHAVEPSASLVPHEDPSLLWINSG VATLKKYFDGRVVPENPRIVNAQKAIRTNDIENVGKTARHHTFFEMLGNFSIGDYFKE EAITWAWEFLTSDKWIGFDKELLSVTVHPEDEEAYEFWAKKIGIPEERIIRLEGNFWD IGEGPSGPNTEIFYDRGEAYGNDPEDPELYPGGENDRYLEVWNLVFSEFNHNPDGTYT PLPKKNIDTGMGLERMVSVIQNVPTNFDTDLFVPIIKATESISGETYGKDNVKDTAFK VIADHIRTVAFAVSDGALPSNEGRGYVLRRLLRRAVRYAKTINIHRPFMFDLVPVVAE IMADFYPEVKEKADFIAKVIKTEEERFHETLNEGLAILSEMIKKEKDKGSSVISGADV FKLYDTYGFPVELTEEYAEDENMTVDHEGFEEEMNQQRERARNARQDVGSMQVQGGAL RDVTVESTFVGYSQTKADANIIVLLQDGQLIEEAHEGESVQIILDETPFYAESGGQIG DKGYLRSEQAVVRIKDVQKAPNGQHVHEGVVESGTVQKGLHVTAEVEDHMRSGVIKNH TATHLLHQALKDVLGTHVNQAGSLVTENRLRFDFSHFGQVTKEELEQIERIVNEKIWA SIPVSIDLKPIAEAKEMGAMALFGEKYGDIVRVVQVGDYSLELCGGCHVRNTAEIGLF KIVSESGIGAGTRRIEAVTGQGAYVEMNSQISVLKQTADELKTNIKEVPKRVAALQAE LKDAQRENESLLAKLGNVEAGAILSKVKEVDGVNVLAAKVNAKDMNHLRTMVDELKAK LGSAVIVLGAVQNDKVNISAGVTKDLIEKGLHAGKLVKQAAEVCGGGGGGRPDMAQAG GKQPEKLEEALASVEDWVKSVL*" /label="alaS CDS" gene complement(2422498..2425134) /gene="alaS" /locus_tag="BSU_27410" /old_locus_tag="BSU27410" /label="alaS gene" promotor_-35 complement(2422501..2422508) /Source="Nicolas_upshift_promotors" /id="U2113" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.57042957042957" /psig="0.994005994005994" /xcortree=3173 /SigmaFactorBS="ggcttctgtagaagattgggtgaaatCCGTTTTAtaattcgc ccatgTAGTGTAGAATGATGGTAAGattaggaccccaggctgaactttgcctgcgaat t" /listShort="S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2424900..2424918) /Source="Nicolas_upshift_promotors" /id="U2114" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1639 /SigmaFactorBS="cggccgtgtcgtgccggaaaatccaagaatcgtaaacGCTCA AAAagcgatcagaacaAACGATATAGAAAATGTAGgtaaaactgcgcgccatcacact t" /listShort="S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2424916) /Source="Nicolas_upshifts" /id="U2114" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1639 /SigmaFactorBS="cggccgtgtcgtgccggaaaatccaagaatcgtaaacGCTCA AAAagcgatcagaacaAACGATATAGAAAATGTAGgtaaaactgcgcgccatcacact t" /listShort="S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2424932..2424939) /Source="Nicolas_upshift_promotors" /id="U2114" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1639 /SigmaFactorBS="cggccgtgtcgtgccggaaaatccaagaatcgtaaacGCTCA AAAagcgatcagaacaAACGATATAGAAAATGTAGgtaaaactgcgcgccatcacact t" /listShort="S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2425135..2425213) /Source="Nicolas_S_feature" /locus_tag="new_2800811_2800889_c" /HighExp="G150, LBGexp, G135, G180, Oxctl, LBGtran, Lbexp, Paraq, dia15, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1040" misc_RNA complement(2425214..2425421) /gene="tboA" /locus_tag="BSU_misc_RNA_40" /product="T-box riboswitch specific of alanine tRNA" /experiment="publication(s) with functional evidences, PMID:1317842, 9098041, 12165569, 12547201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1317842, 9098041, 12165569, 12547201; Product type n: RNA" /function="16.3: Control" /label="tboA RNA" gene complement(2425214..2425421) /gene="tboA" /locus_tag="BSU_misc_RNA_40" /label="tboA gene" promotor_-10 complement(2425429..2425448) /Source="Nicolas_upshift_promotors" /id="U2115" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.84015984015984" /psig=1 /xcortree=2558 /SigmaFactorBS="aatgatgatccattttttgcggatgaggacggagCATTGACA tcggcgtgccgcttGTCTATAATTTCTCGTAGAAtacatacgaatctcgagtgacgga t" /listShort="NA, S1040, alaS, S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2425444) /Source="Nicolas_upshifts" /id="U2115" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.84015984015984" /psig=1 /xcortree=2558 /SigmaFactorBS="aatgatgatccattttttgcggatgaggacggagCATTGACA tcggcgtgccgcttGTCTATAATTTCTCGTAGAAtacatacgaatctcgagtgacgga t" /listShort="NA, S1040, alaS, S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2425463..2425470) /Source="Nicolas_upshift_promotors" /id="U2115" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.84015984015984" /psig=1 /xcortree=2558 /SigmaFactorBS="aatgatgatccattttttgcggatgaggacggagCATTGACA tcggcgtgccgcttGTCTATAATTTCTCGTAGAAtacatacgaatctcgagtgacgga t" /listShort="NA, S1040, alaS, S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2425465..2426526) /gene="yrrI" /locus_tag="BSU_27420" /old_locus_tag="BSU27420" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative membrane protein of unknown function" /protein_id="NP_390619.1" /db_xref="EnsemblGenomes-Gn:BSU27420" /db_xref="EnsemblGenomes-Tr:CAB14683" /db_xref="GOA:O34472" /db_xref="InterPro:IPR002549" /db_xref="SubtiList:BG13791" /db_xref="UniProtKB/Swiss-Prot:O34472" /translation="MLQKPVQLLLWVAICLLVLLTVYVFFMLDMLWSPFWLVIKTIFI PLIISIFISYLLLPVTEWLHGKGLPRTLSILVIYVLFFGGIGWALYKGVPVLIVQLTD LSENIPMFAETYNGLLLHVHNHTDDWPDGMHHRIDKMIRQTEAFFAGTIEGAISGIRN VLDYFLIAATIPFLVFYMVKDIELMKKTVWYLTPKSWRKRGSAFLRDVDDSLGDYIRG QLLVCLILGVIAGISFWVFGLPYPLILGLISGVTNVIPYFGPFIGAVPALLIAMTISV KAVLVVVITVFILQFMEGNILSPFIVGRSLKMHPVVIMLALLAGGELAGIVGMILAVP ATAVLKVMMIHFLRMRTEH*" /label="yrrI CDS" gene complement(2425465..2426526) /gene="yrrI" /locus_tag="BSU_27420" /old_locus_tag="BSU27420" /label="yrrI gene" promotor_-35 2426435..2426440 /Source="Nicolas_upshift_promotors" /id="U2116" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1047 /SigmaFactorBS="atcaagggaataaagatcgtttttatgacgagccaaaagggt gaccatAACATAtcaagcataaaaaagACATAGACTGTTAACAGAAccagcaaacaaa t" /listShort="S1041, glnQ, glnH, glnM, glnP" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2426446..2426681 /Source="Nicolas_S_feature" /locus_tag="new_2802122_2802357" /HighExp="S5, S6, S4, S8, S3, S7, LoTm, BT, M9-stat, T5.0H" /AntisenseName="yrrI" /AntisenseCor="0.71790030040923003" /AntisenseRegPval="-43.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1041" upshifts 2426447 /Source="Nicolas_upshifts" /id="U2116" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1047 /SigmaFactorBS="atcaagggaataaagatcgtttttatgacgagccaaaagggt gaccatAACATAtcaagcataaaaaagACATAGACTGTTAACAGAAccagcaaacaaa t" /listShort="S1041, glnQ, glnH, glnM, glnP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2426456..2426474 /Source="Nicolas_upshift_promotors" /id="U2116" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1047 /SigmaFactorBS="atcaagggaataaagatcgtttttatgacgagccaaaagggt gaccatAACATAtcaagcataaaaaagACATAGACTGTTAACAGAAccagcaaacaaa t" /listShort="S1041, glnQ, glnH, glnM, glnP" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2426543..2426554) /Source="Nicolas_upshift_promotors" /id="U2117" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=801 /SigmaFactorBS="catgacttctgactgactaaagaaacataaAGAATAAttcct tgtaaaccTCAAAAGATATAggtgaggtgaaagcagatgctccaaaaaccggtgcagc t" /listShort="yrrI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2426544) /Source="Nicolas_upshifts" /id="U2117" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=801 /SigmaFactorBS="catgacttctgactgactaaagaaacataaAGAATAAttcct tgtaaaccTCAAAAGATATAggtgaggtgaaagcagatgctccaaaaaccggtgcagc t" /listShort="yrrI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2426568..2426574) /Source="Nicolas_upshift_promotors" /id="U2117" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=801 /SigmaFactorBS="catgacttctgactgactaaagaaacataaAGAATAAttcct tgtaaaccTCAAAAGATATAggtgaggtgaaagcagatgctccaaaaaccggtgcagc t" /listShort="yrrI" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2426682..2427410 /gene="glnQ" /locus_tag="BSU_27430" /old_locus_tag="BSU27430" /EC_number="3.6.3.-" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1856180; Product type t : transporter" /codon_start=1 /transl_table=11 /product="glutamine ABC transporter (ATP-binding protein)" /protein_id="NP_390620.1" /db_xref="EnsemblGenomes-Gn:BSU27430" /db_xref="EnsemblGenomes-Tr:CAB14684" /db_xref="GOA:O34677" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030679" /db_xref="SubtiList:BG11485" /db_xref="UniProtKB/Swiss-Prot:O34677" /translation="MITFQNVNKHYGDFHVLKQINLQIEKGEVVVIIGPSGSGKSTLL RCINRLESINEGVLTVNGTAINDRKTDINQVRQNIGMVFQHFHLYPHKTVLQNIMLAP VKVLRQSPEQAKETARYYLEKVGIPDKADAYPSQLSGGQQQRVAIARGLAMKPEVMLF DEPTSALDPEMIGEVLDVMKTLAKEGMTMVVVTHEMGFAKEVADRIVFIDEGKILEEA VPAEFYANPKEERARLFLSRILNH*" /label="glnQ CDS" gene 2426682..2427410 /gene="glnQ" /locus_tag="BSU_27430" /old_locus_tag="BSU27430" /label="glnQ gene" downshifts complement(2427138) /Source="Nicolas_upshifts" /id="D1402" /incds=1 /nref=1 /ntot=9 /MaxReadThrough="1.29649" /MaxDrop="3.29152" /score="-3.35464926" /energy="-5.4" /TU="NA" /idTUdmin="U2117" /TUdmin="-726" /isTUend="FALSE" /label="downshifts" CDS 2427432..2428253 /gene="glnH" /locus_tag="BSU_27440" /old_locus_tag="BSU27440" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1856180; Product type lp : lipoprotein" /codon_start=1 /transl_table=11 /product="glutamine ABC transporter (glutamine-binding lipoprotein)" /protein_id="NP_390621.1" /db_xref="EnsemblGenomes-Gn:BSU27440" /db_xref="EnsemblGenomes-Tr:CAB14685" /db_xref="GOA:O34563" /db_xref="InterPro:IPR001320" /db_xref="InterPro:IPR001638" /db_xref="InterPro:IPR018313" /db_xref="SubtiList:BG11486" /db_xref="UniProtKB/Swiss-Prot:O34563" /translation="MKKIFSLALISLFAVILLAACGSKGSNGEASKESKKDTLAAIKD NDKIVFGVKTDTRLFGLKNPSSGEIEGFDIDIAKQIAKDILGDEKKAQFKEVTSKTRI PMLQNGDIDAIVATMTITEERKKEVDFSDVYFEAGQSLLVKKGSKIKSVENLGKGSKV LAVKGSTSSQNIREKAPEASVLEFENYAEAFTALKSGQGDALTTDNAILYGMADENKN YQLTGKPFTDEPYGIAVKKGQSALAKEINASLKKMKSDGRYDEIYKKWIKEDPAE*" /label="glnH CDS" gene 2427432..2428253 /gene="glnH" /locus_tag="BSU_27440" /old_locus_tag="BSU27440" /label="glnH gene" CDS 2428314..2428964 /gene="glnM" /locus_tag="BSU_27450" /old_locus_tag="BSU27450" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1856180, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glutamine ABC transporter (permease)" /protein_id="NP_390622.1" /db_xref="EnsemblGenomes-Gn:BSU27450" /db_xref="EnsemblGenomes-Tr:CAB14686" /db_xref="GOA:O34671" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11487" /db_xref="UniProtKB/Swiss-Prot:O34671" /translation="MNVSILFDNFSMYMDGFYHTLLASVIALAGSFVLGVAVAVMRIT VFKPLQWLGTAYVEFIRNIPLLLITFVFYFGLPNAGLRLDGFQAGTVALTIYTSAFIA EAIRAGIQSVSKGQMEAARSSGFTYSQAMLHIILPQAIKIVIPPLGNQFLNLVKNSSI LGVVAGLDLMYQADLVSSSTLVVFDVYIFVALFYLVLTIPLSIGVNYLEKRLEKSY*" /label="glnM CDS" gene 2428314..2428964 /gene="glnM" /locus_tag="BSU_27450" /old_locus_tag="BSU27450" /label="glnM gene" CDS 2428981..2429637 /gene="glnP" /locus_tag="BSU_27460" /old_locus_tag="BSU27460" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1856180, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glutamine ABC transporter (permease)" /protein_id="NP_390623.1" /db_xref="EnsemblGenomes-Gn:BSU27460" /db_xref="EnsemblGenomes-Tr:CAB14687" /db_xref="GOA:O34606" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11488" /db_xref="UniProtKB/Swiss-Prot:O34606" /translation="MDFIGAYSQEHLAFLWDGFLVTLYVAFISIILSFFFGLIAGTLR YAKVPVLSQLIAVLVETIRNLPLLLIIFFTFFALPEIGIKLEITAAAITALTIFESAM LSEIIRSGLKSIDKGQIEAARSSGLSYTQTLFFIVMPQALRRMVPPIVSQFISLLKDT SLAVVIALPELIHNAQIINGQSADGSYFFPIFLLAALMYFAVNYSLSLAARRLEVRQT *" /label="glnP CDS" gene 2428981..2429637 /gene="glnP" /locus_tag="BSU_27460" /old_locus_tag="BSU27460" /label="glnP gene" downshifts 2429636 /Source="Nicolas_upshifts" /id="D1403" /incds=0 /nref=15 /ntot=32 /MaxReadThrough="2.21558" /MaxDrop="6.08472" /score="5.38937989" /energy="-11.7" /TU="NA" /idTUdmin="U2116" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2429672..2429803) /gene="yrzQ" /locus_tag="BSU_27468" /old_locus_tag="BSU27468" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097766.1" /db_xref="EnsemblGenomes-Gn:BSU27468" /db_xref="EnsemblGenomes-Tr:CAX52672" /db_xref="InterPro:IPR025029" /db_xref="UniProtKB/Swiss-Prot:C0H461" /translation="MNRTMTSLLAMGAGALVYRMATQSDMLNNRSMKRMRRRITKMF* " /label="yrzQ CDS" gene complement(2429672..2429803) /gene="yrzQ" /locus_tag="BSU_27468" /old_locus_tag="BSU27468" /label="yrzQ gene" downshifts complement(2429690) /Source="Nicolas_upshifts" /id="D1404" /incds=0 /nref=50 /ntot=77 /MaxReadThrough="1.58565" /MaxDrop="8.21989" /score="5.69801689" /energy="-11.7" /TU="NA" /idTUdmin="U2118" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2429825..2430016) /gene="yrzR" /locus_tag="BSU_27469" /old_locus_tag="BSU27469" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097767.1" /db_xref="EnsemblGenomes-Gn:BSU27469" /db_xref="EnsemblGenomes-Tr:CAX52673" /db_xref="UniProtKB/Swiss-Prot:C0H462" /translation="MLICPNCKSKDIGKIGVNQYYCWGCFIELTVAKGKIATHQVEED GTLSSLDDLFSEDERSINF*" /label="yrzR CDS" gene complement(2429825..2430016) /gene="yrzR" /locus_tag="BSU_27469" /old_locus_tag="BSU27469" /label="yrzR gene" CDS complement(2430028..2430552) /gene="yrrD" /locus_tag="BSU_27470" /old_locus_tag="BSU27470" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390624.1" /db_xref="EnsemblGenomes-Gn:BSU27470" /db_xref="EnsemblGenomes-Tr:CAB14688" /db_xref="InterPro:IPR011033" /db_xref="InterPro:IPR027275" /db_xref="SubtiList:BG13790" /db_xref="UniProtKB/Swiss-Prot:O34402" /translation="MSLRRKAKPKPVQQKVVDHTLRTCHEVEGFPVYSERTSSYLGTI SDICFSLKGDCLGFILAQKRFLHHHHALLRACDISSIFDDRILASVSSEQLLPLPKSC FTYEQMKMKLVKSQEGDILGMLEDVYFCLDRGIIVAYELSDGFFSDLAGSKRQIQRAD SLVEVRKDEIVLNG*" /label="yrrD CDS" gene complement(2430028..2430552) /gene="yrrD" /locus_tag="BSU_27470" /old_locus_tag="BSU27470" /label="yrrD gene" upshifts complement(2430139) /Source="Nicolas_upshifts" /id="U2118" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.84015984015984" /psig="0.84015984015984" /xcortree=827 /SigmaFactorBS="ggatatattggggatgctggaagaTGTATACttttgtttgga cagGGGCATAATCGTagcatatgaactctcggacggtttcttttctgacctggcggga a" /listShort="yrzR, yrzQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2430143..2430154) /Source="Nicolas_upshift_promotors" /id="U2118" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.84015984015984" /psig="0.84015984015984" /xcortree=827 /SigmaFactorBS="ggatatattggggatgctggaagaTGTATACttttgtttgga cagGGGCATAATCGTagcatatgaactctcggacggtttcttttctgacctggcggga a" /listShort="yrzR, yrzQ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2430169..2430175) /Source="Nicolas_upshift_promotors" /id="U2118" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.84015984015984" /psig="0.84015984015984" /xcortree=827 /SigmaFactorBS="ggatatattggggatgctggaagaTGTATACttttgtttgga cagGGGCATAATCGTagcatatgaactctcggacggtttcttttctgacctggcggga a" /listShort="yrzR, yrzQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2430523..2430534) /Source="Nicolas_upshift_promotors" /id="U2119" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=838 /SigmaFactorBS="agttttttttcatttgcagtggaattgatttcatCGTATGAg tctaaggcgcaaaGCAAAACCTAAGcctgttcaacaaaaggtggttgatcacactttg a" /listShort="yrrD, yrzR, yrzQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2430529) /Source="Nicolas_upshifts" /id="U2119" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=838 /SigmaFactorBS="agttttttttcatttgcagtggaattgatttcatCGTATGAg tctaaggcgcaaaGCAAAACCTAAGcctgttcaacaaaaggtggttgatcacactttg a" /listShort="yrrD, yrzR, yrzQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2430549..2430555) /Source="Nicolas_upshift_promotors" /id="U2119" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=838 /SigmaFactorBS="agttttttttcatttgcagtggaattgatttcatCGTATGAg tctaaggcgcaaaGCAAAACCTAAGcctgttcaacaaaaggtggttgatcacactttg a" /listShort="yrrD, yrzR, yrzQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2430610..2433006) /gene="recDB" /locus_tag="BSU_27480" /old_locus_tag="BSU27480" /EC_number="3.1.11.5" /function="16.9: Replicate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:3537961, 11557815, 21170359, 22720735, 24443534, 28527403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3537961, 11557815, 21170359, 22720735, 24443534, 28527403; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="5'-3' helicase associated to SSB; exonuclease V" /protein_id="NP_390625.1" /db_xref="EnsemblGenomes-Gn:BSU27480" /db_xref="EnsemblGenomes-Tr:CAB14689" /db_xref="GOA:O34481" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR006345" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR027785" /db_xref="InterPro:IPR029493" /db_xref="SubtiList:BG13789" /db_xref="UniProtKB/Swiss-Prot:O34481" /translation="MQQHPDQLKLEEEPYLKGTVNTVIYHNDTNLYTVLKVKVTETSE AIEDKAVSVTGYFPALQEEETYTFYGKIVTHPKFGLQFQAEHFKKEIPTTKEGIIQYL SSDLFEGIGKKTAEEIVKKLGDSAINKILADASVLYDVPRLSKKKADTLAGALQRHQG LEQIMISLNQFGFGPQLSMKIYQAYESETLEKIQENPYQLVKDVEGIGFGKADELGSR MGLSGNHPERVKAAILYTLETTCLSEGHTYIETEQLIIDTQSLLNQSAREGQRITEMD AANAIIALGENKDIVIEDGRCYFPSLFYAEQNVAKRVKHIASQTEYENQFPESEFLLA LGELEERMDVQYAPSQKEAIQKALSSPMLLLTGGPGTGKTTVIRGIVELYGELHGVSL DPSAYKKDEAFPIVLAAPTGRAAKRMSESTGLPAVTIHRLLGWNGAEGFTHTEDQPIE GKLLIIDEASMLDIWLANHLFKAIPDHIQIIIVGDEDQLPSVGPGQVLRDLLASQVIP TVRLTDIYRQAEGSSIVELAHQMKNGLLPNNLTAPTKDRSFIRCGGSQIKEVVEKVVA NALKKGYTAKDIQVLAPMYRGKAGINELNVMLQDILNPPKEKRRELKFGDVVYRTGDK ILQLVNQPENNVFNGDIGEITSIFYAKENTEKEDMAVVSFDGNEMTFTKKDFNQFTHA YCCSIHKSQGSEFPIVVLPVVKGYYRMLRRNLLYTAITRAKKFLILCGEEEALEWGVK NNDATVRQTSLKNRLSVQVEEMDAELEALQKELPFSVHDANIGMEGITPFDFMKEEQQ *" /label="recDB CDS" gene complement(2430610..2433006) /gene="recDB" /locus_tag="BSU_27480" /old_locus_tag="BSU27480" /label="recDB gene" downshifts complement(2430636) /Source="Nicolas_upshifts" /id="D1405" /incds=0 /nref=32 /ntot=211 /MaxReadThrough="2.07603" /MaxDrop="3.57113" /score="41.0323102" /energy="-10.8" /TU="NA" /idTUdmin="U2121" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2430856..2430862 /Source="Nicolas_upshift_promotors" /id="U2120" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=884 /SigmaFactorBS="cctcttccccgcataaaatgagaaatttcttcgctcttgtaa tcgcGGTATAAagaaggtttcttctGAGCATTCTATAatagcctttcacaacaggcaa a" /listShort="S1042" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2430870 /Source="Nicolas_upshifts" /id="U2120" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=884 /SigmaFactorBS="cctcttccccgcataaaatgagaaatttcttcgctcttgtaa tcgcGGTATAAagaaggtttcttctGAGCATTCTATAatagcctttcacaacaggcaa a" /listShort="S1042" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2430877..2430888 /Source="Nicolas_upshift_promotors" /id="U2120" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=884 /SigmaFactorBS="cctcttccccgcataaaatgagaaatttcttcgctcttgtaa tcgcGGTATAAagaaggtttcttctGAGCATTCTATAatagcctttcacaacaggcaa a" /listShort="S1042" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2430890..2431239 /Source="Nicolas_S_feature" /locus_tag="new_2806566_2806915" /HighExp="S8, S5, S6, S7, S4, C30, nit, ferm, G135, T5.0H" /AntisenseName="yrrC" /AntisenseCor="-0.46935785055870999" /AntisenseRegPval="-15.4" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1042" downshifts complement(2430991) /Source="Nicolas_upshifts" /id="D1406" /incds=1 /nref=16 /ntot=163 /MaxReadThrough="4.93428" /MaxDrop="2.86437" /score="41.0323102" /energy="-10.8" /TU="U2121,U2122" /idTUdmin="U2121" /TUdmin="-355" /isTUend="FALSE" /label="downshifts" CDS complement(2433031..2433651) /gene="yrrB" /locus_tag="BSU_27490" /old_locus_tag="BSU27490" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11777911, 12594026, 18180259; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative tetratricopeptide repeat family protein" /protein_id="NP_390626.1" /db_xref="EnsemblGenomes-Gn:BSU27490" /db_xref="EnsemblGenomes-Tr:CAB14690" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR013105" /db_xref="InterPro:IPR019734" /db_xref="PDB:2Q7F" /db_xref="SubtiList:BG13788" /db_xref="UniProtKB/Swiss-Prot:O34452" /translation="MQEGDYEKAAEAFTKAIEENKEDAIPYINFANLLSSVNELERAL AFYDKALELDSSAATAYYGAGNVYVVKEMYKEAKDMFEKALRAGMENGDLFYMLGTVL VKLEQPKLALPYLQRAVELNENDTEARFQFGMCLANEGMLDEALSQFAAVTEQDPGHA DAFYNAGVTYAYKENREKALEMLDKAIDIQPDHMLALHAKKLIDPS*" /label="yrrB CDS" gene complement(2433031..2433651) /gene="yrrB" /locus_tag="BSU_27490" /old_locus_tag="BSU27490" /label="yrrB gene" CDS complement(2433737..2434852) /gene="mnmA" /locus_tag="BSU_27500" /old_locus_tag="BSU27500" /EC_number="2.8.1.13" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12549933, 12756333, 9811540, 15044829, 17580114, 22720735, 25825430" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12549933, 12756333, 9811540, 15044829, 17580114, 22720735, 25825430; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA-specific 2-thiouridylase" /protein_id="NP_390627.3" /db_xref="EnsemblGenomes-Gn:BSU27500" /db_xref="EnsemblGenomes-Tr:CAB14691" /db_xref="GOA:O35020" /db_xref="InterPro:IPR004506" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR023382" /db_xref="SubtiList:BG13787" /db_xref="UniProtKB/Swiss-Prot:O35020" /translation="MEKRPEDTRVVVGMSGGVDSSVAALLLKEQGYDVIGIFMKNWDD TDENGFCTATEDYEDVIRVCNQIGIPYYAVNFEKQYYEKVFQYFLDEYKAGRTPNPDV LCNKEIKFKAFLEHALSLGADYLATGHYARVDRSGGKVRMLRGIDENKDQTYFLNQLT EDTLSKVMFPIGELQKSRVREIAKEAELATATKKDSTGICFIGERNFKTFLSQYLPAQ PGDMMTMDGEVKGRHDGLMYYTIGQRHGLGIGGSGEPWFAVGKDLEKNILYVDQGFHN PLLYSDKITATNISWVRSDIMKGEEISCTAKFRYRQEDHKVTVRMTGEGEAEVIFDEQ VRAVTPGQAVVFYDGEECLGGGTIDDVYKDGTKLWYV*" /label="mnmA CDS" gene complement(2433737..2434852) /gene="mnmA" /locus_tag="BSU_27500" /old_locus_tag="BSU27500" /label="mnmA gene" downshifts complement(2433738) /Source="Nicolas_upshifts" /id="D1407" /incds=0 /nref=2 /ntot=69 /MaxReadThrough="6.45399" /MaxDrop="4.31641" /score="2.49091848" /energy="-7.8" /TU="U2121,U2122" /idTUdmin="U2121" /TUdmin="-3102" /isTUend="FALSE" /label="downshifts" CDS complement(2434883..2436022) /gene="iscSA" /locus_tag="BSU_27510" /old_locus_tag="BSU27510" /EC_number="2.8.1.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7496536, 10930739, 12682299, 17064282, 25825430" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7496536, 10930739, 12682299, 17064282, 25825430; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cysteine desulfurase involved in U34 tRNA thiolation" /protein_id="NP_390629.2" /db_xref="EnsemblGenomes-Gn:BSU27510" /db_xref="EnsemblGenomes-Tr:CAB14693" /db_xref="GOA:O34599" /db_xref="InterPro:IPR000192" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR016454" /db_xref="InterPro:IPR020578" /db_xref="SubtiList:BG13809" /db_xref="UniProtKB/Swiss-Prot:O34599" /translation="MERIYLDHAATSPMDERVLEQMIPHFSGSFGNPSSIHSFGRESR KWVDEARAQIAAEIGAAEQEIIFTSGGTEADNLAIMGTALARKDLGRHIITTKIEHHA VLHTCEKLEGDGFDITYLDVDQNGRVSAKQVKEALRDDTILVTVMYGNNEVGTVQPIE EIGELLKEHKAYFHTDAVQAFGLLPIDVKNSHIDLLSVSGHKLNGPKGTGFLYASKDV KLSPLLFGGEQERKRRAGTENVPGIVGLKEAIKLSSEERDEKNEKYQSFKAIFADTLR DAGVAFEVNGDKEHSLPHVLNLYFPGVSVEALLVNLDMAGVAVSSGSACTAGSVLPSH VLTAMFGEESDRLTSSIRISFGLGNTAEQVKTAAKHVADVVKRLT*" /label="iscSA CDS" gene complement(2434883..2436022) /gene="iscSA" /locus_tag="BSU_27510" /old_locus_tag="BSU27510" /label="iscSA gene" promotor_-10 complement(2435589..2435608) /Source="Nicolas_upshift_promotors" /id="U2121" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.687312687312687" /psig="0.978021978021978" /xcortree=2070 /SigmaFactorBS="acgttgaccaaaatggaagagtcagtgcaaaaCAGGTGAAag aagcactgcgtGATGATACAATCCTTGTGACagtgatgtatggaaataatgaagtcgg a" /listShort="trmU, yrrB, yrrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2435601) /Source="Nicolas_upshifts" /id="U2121" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.687312687312687" /psig="0.978021978021978" /xcortree=2070 /SigmaFactorBS="acgttgaccaaaatggaagagtcagtgcaaaaCAGGTGAAag aagcactgcgtGATGATACAATCCTTGTGACagtgatgtatggaaataatgaagtcgg a" /listShort="trmU, yrrB, yrrC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2435622..2435629) /Source="Nicolas_upshift_promotors" /id="U2121" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.687312687312687" /psig="0.978021978021978" /xcortree=2070 /SigmaFactorBS="acgttgaccaaaatggaagagtcagtgcaaaaCAGGTGAAag aagcactgcgtGATGATACAATCCTTGTGACagtgatgtatggaaataatgaagtcgg a" /listShort="trmU, yrrB, yrrC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2436041..2436457) /gene="cymR" /locus_tag="BSU_27520" /old_locus_tag="BSU27520" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15668000, 16109943, 16513748, 17056751, 18974048, 19508281, 21624051" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15668000, 16109943, 16513748, 17056751, 18974048, 19508281, 21624051; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of cysteine biosynthesis" /protein_id="NP_390630.2" /db_xref="EnsemblGenomes-Gn:BSU27520" /db_xref="EnsemblGenomes-Tr:CAB14694" /db_xref="GOA:O34527" /db_xref="InterPro:IPR000944" /db_xref="InterPro:IPR030489" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2Y75" /db_xref="SubtiList:BG13813" /db_xref="UniProtKB/Swiss-Prot:O34527" /translation="MKISTKGRYGLTIMIELAKKHGEGPTSLKSIAQTNNLSEHYLEQ LVSPLRNAGLVKSIRGAYGGYVLGSEPDAITAGDIIRVLEGPISPVEVLEDEEPAKRE LWIRIRDAVKEVLDSTTLEDLASYTDGEQEAYMFYI*" /label="cymR CDS" gene complement(2436041..2436457) /gene="cymR" /locus_tag="BSU_27520" /old_locus_tag="BSU27520" /label="cymR gene" S_feature complement(2436458..2436555) /Source="Nicolas_S_feature" /locus_tag="new_2812134_2812231_c" /HighExp="Cold, T3.0H, G135, LBGexp, G180, G150, Salt, Lbexp, H2O2, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1043" promotor_-10 complement(2436540..2436559) /Source="Nicolas_upshift_promotors" /id="U2122" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2578 /SigmaFactorBS="cattagaaaagggtaaaggcccctttccttctgcctcAATGa aaattcgctgaaggTATGTTATAATAACAGTTGGtctataagataataaacggacgaa a" /listShort="S1043, cymR, iscS, trmU, yrrB, yrrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2436555) /Source="Nicolas_upshifts" /id="U2122" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2578 /SigmaFactorBS="cattagaaaagggtaaaggcccctttccttctgcctcAATGa aaattcgctgaaggTATGTTATAATAACAGTTGGtctataagataataaacggacgaa a" /listShort="S1043, cymR, iscS, trmU, yrrB, yrrC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2436575..2436578) /Source="Nicolas_upshift_promotors" /id="U2122" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2578 /SigmaFactorBS="cattagaaaagggtaaaggcccctttccttctgcctcAATGa aaattcgctgaaggTATGTTATAATAACAGTTGGtctataagataataaacggacgaa a" /listShort="S1043, cymR, iscS, trmU, yrrB, yrrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2436603..2436610 /Source="Nicolas_upshift_promotors" /id="U2123" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=1971 /SigmaFactorBS="tttcattgaggcagaaggaaaggggcctttaCCCTTTTCtaa tgtacggtttTCCGTTACCCTGTAATTAAGtaaggagagatgatagatgaagccattg g" /listShort="yrvN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2436624..2436643 /Source="Nicolas_upshift_promotors" /id="U2123" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=1971 /SigmaFactorBS="tttcattgaggcagaaggaaaggggcctttaCCCTTTTCtaa tgtacggtttTCCGTTACCCTGTAATTAAGtaaggagagatgatagatgaagccattg g" /listShort="yrvN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2436632 /Source="Nicolas_upshifts" /id="U2123" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=1971 /SigmaFactorBS="tttcattgaggcagaaggaaaggggcctttaCCCTTTTCtaa tgtacggtttTCCGTTACCCTGTAATTAAGtaaggagagatgatagatgaagccattg g" /listShort="yrvN" /GFF_Attribute="listLong" /label="upshifts" CDS 2436660..2437925 /gene="rarA" /locus_tag="BSU_27530" /old_locus_tag="BSU27530" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15743409, 17641684, 21170359" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15743409, 17641684, 21170359; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA-dependent ATPase active at replication forks" /protein_id="NP_390631.1" /db_xref="EnsemblGenomes-Gn:BSU27530" /db_xref="EnsemblGenomes-Tr:CAB14695" /db_xref="GOA:O34528" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR008824" /db_xref="InterPro:IPR008921" /db_xref="InterPro:IPR021886" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032423" /db_xref="SubtiList:BG13808" /db_xref="UniProtKB/Swiss-Prot:O34528" /translation="MKPLAYRMRPTKIEDIIGQQHLVAEDKIIGRMVQAKHLSSMILY GPPGIGKTSIATAIAGSTSIAFRKLNAVINNKKDMEIVAQEAKMSGQVILILDEVHRL DKGKQDFLLPYLENGMIILIGATTANPYHAINPAIRSRTQIFELEPLTPELIKQALER ALHDEHRGLGTYSVSIDDQAMEHFAHGCGGDVRSALNALELAVLSTKESADGEIHITL ETAEECLQKKSFSHDKDGDAHYDVLSAFQKSIRGSDANAALHYLARLIEAGDLESIAR RLLVIAYEDIGLASPQAGPRVLNAIQTAERVGFPEARIPLANAVIELCLSPKSNSAIL AIDEALADIRAGKIGDVPKHLKDAHYKGAQELGRGIDYKYPHNYDNGWVEQQYLPDPL KNKQYYKPKQTGKFESALKQVYDKLMKRK*" /label="rarA CDS" gene 2436660..2437925 /gene="rarA" /locus_tag="BSU_27530" /old_locus_tag="BSU27530" /label="rarA gene" downshifts 2437924 /Source="Nicolas_upshifts" /id="D1408" /incds=0 /nref=24 /ntot=228 /MaxReadThrough="1.09429" /MaxDrop="4.5261" /score="14.6665846" /energy="-12" /TU="NA" /idTUdmin="U2123" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(2437967..2438731) /gene="tcdA" /locus_tag="BSU_27540" /old_locus_tag="BSU27540" /EC_number="6.1.-.-" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12177353, 20097860, 23242255, 27913733, 28671653; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA threonylcarbamoyladenosine dehydratase (t(6)A37 dehydratase)" /protein_id="NP_390632.3" /db_xref="EnsemblGenomes-Gn:BSU27540" /db_xref="EnsemblGenomes-Tr:CAB14713" /db_xref="GOA:O32037" /db_xref="InterPro:IPR000594" /db_xref="InterPro:IPR035985" /db_xref="SubtiList:BG13807" /db_xref="UniProtKB/Swiss-Prot:O32037" /translation="MLHQFSRNELAIGKEGLETLKNSTVAVLGVGGVGSFAAEALARS GVGRILLVDKDDVDITNVNRQLHALLSTVGQPKVDLMKARIADINPECEVIALKMFYT EETYEQFFDYGLDYVIDASDTICYKIHLMKECLKRDIPLISSMGAANKTDPTRFQIAD ISKTHTDPIAKVVRTKLRKEGIKKGVQVIFSDESPIVIREDVRKEVGNDEAKIRKAKM PPSSNAFVPSVAGLIMGGHVVMDLLKDIEIKRVKDK*" /label="tcdA CDS" gene complement(2437967..2438731) /gene="tcdA" /locus_tag="BSU_27540" /old_locus_tag="BSU27540" /label="tcdA gene" downshifts complement(2437985) /Source="Nicolas_upshifts" /id="D1409" /incds=0 /nref=246 /ntot=264 /MaxReadThrough="2.35294" /MaxDrop="7.20309" /score="44.7253801" /energy="-12" /TU="NA" /idTUdmin="U2125" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_RNA complement(2438815..2439015) /gene="ssrSB" /locus_tag="BSU_misc_RNA_41" /product="6Sb RNA" /experiment="publication(s) with functional evidences, PMID:12177353, 15793584, 15811922, 25576829, 26873600" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12177353, 15793584, 15811922, 25576829, 26873600; Product type n: RNA" /label="ssrSB RNA" gene complement(2438815..2439015) /gene="ssrSB" /locus_tag="BSU_misc_RNA_41" /label="ssrSB gene" downshifts complement(2438833) /Source="Nicolas_upshifts" /id="D1410" /incds=0 /nref=81 /ntot=303 /MaxReadThrough="7.44881" /MaxDrop="6.73892" /score="44.7253801" /energy="-12" /TU="U2125,U2127" /idTUdmin="U2125" /TUdmin="-848" /isTUend="FALSE" /label="downshifts" upshifts 2439002 /Source="Nicolas_upshifts" /id="U2124" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.425574425574426" /psig="0.143856143856144" /xcortree=714 /SigmaFactorBS="gcgggctcccaaatcaaaaaaatgttcggtcaaaactaggtg tacaactaacacatcaggaCTTTATTTAActtgtcaaaatcatatcacagacgatttt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 2439003..2439012 /Source="Nicolas_upshift_promotors" /id="U2124" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.425574425574426" /psig="0.143856143856144" /xcortree=714 /SigmaFactorBS="gcgggctcccaaatcaaaaaaatgttcggtcaaaactaggtg tacaactaacacatcaggaCTTTATTTAActtgtcaaaatcatatcacagacgatttt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(2439013..2439032) /Source="Nicolas_upshift_promotors" /id="U2125" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig=1 /xcortree=392 /SigmaFactorBS="aaaaaagttaagaactgaatttgcagttcgatTCTTGAAAat caaaatcgtcTGTGATATGATTTTGACAAGttaaataaagtcctgatgtgttagttgt a" /listShort="NA, yrvM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2439024) /Source="Nicolas_upshifts" /id="U2125" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig=1 /xcortree=392 /SigmaFactorBS="aaaaaagttaagaactgaatttgcagttcgatTCTTGAAAat caaaatcgtcTGTGATATGATTTTGACAAGttaaataaagtcctgatgtgttagttgt a" /listShort="NA, yrvM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2439045..2439052) /Source="Nicolas_upshift_promotors" /id="U2125" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig=1 /xcortree=392 /SigmaFactorBS="aaaaaagttaagaactgaatttgcagttcgatTCTTGAAAat caaaatcgtcTGTGATATGATTTTGACAAGttaaataaagtcctgatgtgttagttgt a" /listShort="NA, yrvM" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2439067..2440845) /gene="aspS" /locus_tag="BSU_27550" /old_locus_tag="BSU27550" /EC_number="6.1.1.12" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12177353, 26804570" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12177353, 26804570; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aspartyl-tRNA synthetase, promiscuous (also recognizes tRNAasn)" /protein_id="NP_390633.1" /db_xref="EnsemblGenomes-Gn:BSU27550" /db_xref="EnsemblGenomes-Tr:CAB14714" /db_xref="GOA:O32038" /db_xref="InterPro:IPR002312" /db_xref="InterPro:IPR004115" /db_xref="InterPro:IPR004364" /db_xref="InterPro:IPR004365" /db_xref="InterPro:IPR004524" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR029351" /db_xref="SubtiList:BG12572" /db_xref="UniProtKB/Swiss-Prot:O32038" /translation="MFGRTYYCGDITEKAIGESVTLKGWVQKRRDLGGLIFIDLRDRT GIVQVVFNPDVSKEALAIAEGIRNEYVLDIQGKVVAREEGTVNPNLKTGAIEIHADGV NVLNAAKTPPFAISDQAEEVSEDVRLKHRYLDLRRPAMFQTMQLRHNVTKAVRSFLDE NGFLDIETPILTGSTPEGARDYLVPSRVHEGEFYALPQSPQLFKQLLMVSGIERYYQI ARCFRDEDLRADRQPEFTQIDIEMSFMSQEDIMSLAEEMMAKVMRETKGEELQLPLPR MTYDEAMNKYGSDKPDTRFDMLLTDVSDIVKDTEFKVFSSAVANGGVVKAINVKGGAG DYSRKDIDALGAFAANYGAKGLAWVKVEADGVKGPIAKFFDEEKQSKLIEALDAAEGD LLLFGADQFEVVAASLGALRLKLGKERGLIDEKLFNFLWVIDWPLLEHDPEEGRFYAA HHPFTMPVREDLELIETAPEDMKAQAYDLVLNGYELGGGSIRIFEKDIQEKMFALLGF SPEEAAEQFGFLLEAFEYGAPPHGGIALGLDRLVMLLAGRTNLRDTIAFPKTASASCL MTEAPGEVSDAQLDELHLSIKKKVKN*" /label="aspS CDS" gene complement(2439067..2440845) /gene="aspS" /locus_tag="BSU_27550" /old_locus_tag="BSU27550" /label="aspS gene" CDS complement(2440859..2442133) /gene="hisS" /locus_tag="BSU_27560" /old_locus_tag="BSU27560" /EC_number="6.1.1.21" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 28321488; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="histidyl-tRNA synthetase" /protein_id="NP_390634.1" /db_xref="EnsemblGenomes-Gn:BSU27560" /db_xref="EnsemblGenomes-Tr:CAB14715" /db_xref="GOA:O32039" /db_xref="InterPro:IPR004154" /db_xref="InterPro:IPR004516" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR015807" /db_xref="InterPro:IPR033656" /db_xref="InterPro:IPR036621" /db_xref="SubtiList:BG12605" /db_xref="UniProtKB/Swiss-Prot:O32039" /translation="MGYNIPRGTQDILPGESDRWQFVEQIMRDTCRTYQYKEIRTPIF EHTELFARGVGESTDIVQKEMYTFEDRKGRSLTLRPEGTAAAVRAFNENKLFANPVQP TKLYYVGPMFRYERPQTGRYRQFYQFGIEAIGSKDPAIDAEVMALAMSIYEKAGLENV KLVINSLGDQDSRKSYREALVKHFEPRIEEFCSDCQSRLHTNPLRILDCKKDRDHELM KSAPSILTYLNEESAAYFEKVKQYLNDLGISYEIDPNLVRGLDYYNHTAFEIMSNAEG FGAITTLAGGGRYDGLVEQIGGPEAPGIGFAMSIERLLAAIDAEKRELPVDKGIDCYI VTLGEKAKDYSVSLVYKLREAGISSEIDYENKKMKGQFKTADRLKARFIAILGEDELA QNKINVKDAQTGEQIEVALDEFIHVMKANQKG*" /label="hisS CDS" gene complement(2440859..2442133) /gene="hisS" /locus_tag="BSU_27560" /old_locus_tag="BSU27560" /label="hisS gene" misc_RNA complement(2442223..2442455) /gene="tboH" /locus_tag="BSU_misc_RNA_42" /product="T-box riboswitch controlling synthesis of histidine and aspartate tRNA ligases" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.3: Control" /label="tboH RNA" gene complement(2442223..2442455) /gene="tboH" /locus_tag="BSU_misc_RNA_42" /label="tboH gene" downshifts complement(2442253) /Source="Nicolas_upshifts" /id="D1411" /incds=0 /nref=71 /ntot=180 /MaxReadThrough="7.0761" /MaxDrop="5.61082" /score="40.6097692" /energy="-23.7" /TU="U2127" /idTUdmin="U2128" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2442465..2442468 /Source="Nicolas_upshift_promotors" /id="U2126" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.582417582417582" /psig=1 /xcortree=2538 /SigmaFactorBS="ctgacctactcttctccattattggttcaaatctttcatcAT TTgctatgtactcaatTTCTATTATAATAATGGGATtggggttctctgtcaagcttta t" /listShort="S1044, yrvJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2442479..2442498) /Source="Nicolas_upshift_promotors" /id="U2127" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.9000999000999" /psig=1 /xcortree=3008 /SigmaFactorBS="ccaaagaagcagcgctgaggaaaaacaaccggaataaaGCTT GACAgagaaccccaatccCATTATTATAATAGAAATTGagtacatagcaaatgatgaa a" /listShort="NA, hisS, aspS, NA, yrvM" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2442483..2442502 /Source="Nicolas_upshift_promotors" /id="U2126" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.582417582417582" /psig=1 /xcortree=2538 /SigmaFactorBS="ctgacctactcttctccattattggttcaaatctttcatcAT TTgctatgtactcaatTTCTATTATAATAATGGGATtggggttctctgtcaagcttta t" /listShort="S1044, yrvJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2442485..2442769 /Source="Nicolas_S_feature" /locus_tag="new_2818161_2818445" /HighExp="H2O2, G135, G180, C30, G150, Paraq, Oxctl, dia15, LBGstat, LBGexp" /AntisenseName="yrzK" /AntisenseCor="-0.27832941694878799" /AntisenseRegPval="-5.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1044" upshifts 2442485 /Source="Nicolas_upshifts" /id="U2126" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.582417582417582" /psig=1 /xcortree=2538 /SigmaFactorBS="ctgacctactcttctccattattggttcaaatctttcatcAT TTgctatgtactcaatTTCTATTATAATAATGGGATtggggttctctgtcaagcttta t" /listShort="S1044, yrvJ" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2442498) /Source="Nicolas_upshifts" /id="U2127" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.9000999000999" /psig=1 /xcortree=3008 /SigmaFactorBS="ccaaagaagcagcgctgaggaaaaacaaccggaataaaGCTT GACAgagaaccccaatccCATTATTATAATAGAAATTGagtacatagcaaatgatgaa a" /listShort="NA, hisS, aspS, NA, yrvM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2442513..2442520) /Source="Nicolas_upshift_promotors" /id="U2127" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.9000999000999" /psig=1 /xcortree=3008 /SigmaFactorBS="ccaaagaagcagcgctgaggaaaaacaaccggaataaaGCTT GACAgagaaccccaatccCATTATTATAATAGAAATTGagtacatagcaaatgatgaa a" /listShort="NA, hisS, aspS, NA, yrvM" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2442515..2442685) /gene="yrzK" /locus_tag="BSU_27570" /old_locus_tag="BSU27570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390635.1" /db_xref="EnsemblGenomes-Gn:BSU27570" /db_xref="EnsemblGenomes-Tr:CAB14716" /db_xref="InterPro:IPR035378" /db_xref="SubtiList:BG13820" /db_xref="UniProtKB/Swiss-Prot:O32040" /translation="MKYHPKMGRAFHDGEANLHYSDHADPDTTGYLTETASEFGLMSK EAALRKNNRNKA*" /label="yrzK CDS" gene complement(2442515..2442685) /gene="yrzK" /locus_tag="BSU_27570" /old_locus_tag="BSU27570" /label="yrzK gene" promotor_-10 complement(2442716..2442727) /Source="Nicolas_upshift_promotors" /id="U2128" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.945054945054945" /psig="0.945054945054945" /xcortree=906 /SigmaFactorBS="taaaaaagcattcttgtttaatatcgtaaagtcctttctgat tttTAAATAAaaataaaatgatttGTTTATACTAAGcgtaaatacaatcaaaaaggtg t" /listShort="yrzK, NA" /listLong="hisS, aspS, NA, yrvM" /label="promotor_-10" upshifts complement(2442733) /Source="Nicolas_upshifts" /id="U2128" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.945054945054945" /psig="0.945054945054945" /xcortree=906 /SigmaFactorBS="taaaaaagcattcttgtttaatatcgtaaagtcctttctgat tttTAAATAAaaataaaatgatttGTTTATACTAAGcgtaaatacaatcaaaaaggtg t" /listShort="yrzK, NA" /listLong="hisS, aspS, NA, yrvM" /label="upshifts" promotor_-35 complement(2442742..2442748) /Source="Nicolas_upshift_promotors" /id="U2128" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.945054945054945" /psig="0.945054945054945" /xcortree=906 /SigmaFactorBS="taaaaaagcattcttgtttaatatcgtaaagtcctttctgat tttTAAATAAaaataaaatgatttGTTTATACTAAGcgtaaatacaatcaaaaaggtg t" /listShort="yrzK, NA" /listLong="hisS, aspS, NA, yrvM" /label="promotor_-35" promotor_-35 2442745..2442752 /Source="Nicolas_upshift_promotors" /id="U2129" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2794 /SigmaFactorBS="ttacgcttagtataaacaaatcattttatttttaTTTAAAAA tcagaaaggacttTACGATATTAAACAAGAATgcttttttaatgatcatcagaaagga g" /listShort="yrvJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2442766..2442784 /Source="Nicolas_upshift_promotors" /id="U2129" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2794 /SigmaFactorBS="ttacgcttagtataaacaaatcattttatttttaTTTAAAAA tcagaaaggacttTACGATATTAAACAAGAATgcttttttaatgatcatcagaaagga g" /listShort="yrvJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2442771 /Source="Nicolas_upshifts" /id="U2129" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2794 /SigmaFactorBS="ttacgcttagtataaacaaatcattttatttttaTTTAAAAA tcagaaaggacttTACGATATTAAACAAGAATgcttttttaatgatcatcagaaagga g" /listShort="yrvJ" /GFF_Attribute="listLong" /label="upshifts" CDS 2442818..2444374 /gene="yrvJ" /locus_tag="BSU_27580" /old_locus_tag="BSU27580" /EC_number="3.5.1.28" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetylmuramoyl-L-alanine amidase, family 3" /protein_id="NP_390636.1" /db_xref="EnsemblGenomes-Gn:BSU27580" /db_xref="EnsemblGenomes-Tr:CAB14717" /db_xref="GOA:O32041" /db_xref="InterPro:IPR002508" /db_xref="InterPro:IPR003646" /db_xref="InterPro:IPR017293" /db_xref="SubtiList:BG13806" /db_xref="UniProtKB/Swiss-Prot:O32041" /translation="MNKKYFVLIVCIIFTSALFPTFSSVTAAQGEAVIATDEMNVRSG PGLSYGITAEVKKGERYPILKEDGDWVQIQLGSGEKGWVVSWLITKEDQASTSSSGSS DTVTSTDPDLRMRSGPGTSYEVIGKFPQGSQASVIDKDSGWIKISYHSATGWVSSEYV TSGGSSSASDESDQTEDSGASTTGTVGVSSLNVRASASHDAAIITKLDRGTKLTVLNE KNGWAHIEVNGLKGWVASHYLLTSSVPADDSANAGSSSSAKKAYIMYGGTNLRSDAST SASIVERAAKGDSYTITGSKGSWYEIKLDNGQTAYVANWVVQTSKSAEEAGEPPVSDS PSGNGSLNNKTIIVDPGHGGKDSGTIGYSGKFEKNLTIKTAKLLASKLRSAGADVYVT RQDDTFVSLQSRVSTSHYRNADAFISIHYDSYADTSTRGSTAYYYSPAKDQELASDVH SEVVKRSSIPDRGVLFGDYYVLRENRQPAMLYELGYVSHPQEEAIVHSNSYQEKVTDG IESGLEKYFQ*" /label="yrvJ CDS" gene 2442818..2444374 /gene="yrvJ" /locus_tag="BSU_27580" /old_locus_tag="BSU27580" /label="yrvJ gene" downshifts 2444353 /Source="Nicolas_upshifts" /id="D1412" /incds=0 /nref=199 /ntot=249 /MaxReadThrough="2.10072" /MaxDrop="7.40599" /score="44.9570925" /energy="-9.9" /TU="U2126" /idTUdmin="U2129" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(2444401..2444799) /gene="dtd" /locus_tag="BSU_27590" /old_locus_tag="BSU27590" /EC_number="3.1.-.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15292242, 15525705, 16844682, 18700836, 28362257; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="gly-tRNA(Ala) deacylase / D-Tyr-tRNATyr deacylase" /protein_id="NP_390637.2" /db_xref="EnsemblGenomes-Gn:BSU27590" /db_xref="EnsemblGenomes-Tr:CAB14718" /db_xref="GOA:O32042" /db_xref="InterPro:IPR003732" /db_xref="InterPro:IPR023509" /db_xref="SubtiList:BG13805" /db_xref="UniProtKB/Swiss-Prot:O32042" /translation="MDEEVVGQIGQGLMVLVGITHDDTEDDAAYLADKVVNLRIFDDS EGKMNLSLVDIGGEILSVSQFTLYGDTKKGRRPNYMNAAKPDKALGLYEKWNDLLREK GIKVETGTFGAMMDVQLTNSGPVTLIMDSK*" /label="dtd CDS" gene complement(2444401..2444799) /gene="dtd" /locus_tag="BSU_27590" /old_locus_tag="BSU27590" /label="dtd gene" downshifts complement(2444409) /Source="Nicolas_upshifts" /id="D1413" /incds=0 /nref=152 /ntot=267 /MaxReadThrough="2.01735" /MaxDrop="9.47739" /score="37.3693259" /energy="-9.9" /TU="NA" /idTUdmin="U2130" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2444853..2447057) /gene="rsh" /locus_tag="BSU_27600" /old_locus_tag="BSU27600" /EC_number="2.7.6.5" /EC_number="3.1.7.2" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:6248722, 9383190, 11545276, 12081964, 12372825, 13129942, 15066282, 17183219, 18067544, 18996989, 26460002" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6248722, 9383190, 11545276, 12081964, 12372825, 13129942, 15066282, 17183219, 18067544, 18996989, 26460002; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="GTP pyrophosphokinase (RelA/SpoT)" /protein_id="NP_390638.2" /db_xref="EnsemblGenomes-Gn:BSU27600" /db_xref="EnsemblGenomes-Tr:CAB14719" /db_xref="GOA:O54408" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR004095" /db_xref="InterPro:IPR004811" /db_xref="InterPro:IPR007685" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR012676" /db_xref="InterPro:IPR033655" /db_xref="SubtiList:BG12665" /db_xref="UniProtKB/Swiss-Prot:O54408" /translation="MANEQVLTAEQVIDKARSYLSDEHIAFVEKAYLYAEDAHREQYR KSGEPYIIHPIQVAGILVDLEMDPSTIAGGFLHDVVEDTDVTLDDLKEAFSEEVAMLV DGVTKLGKIKYKSQEEQQAENHRKMFVAMAQDIRVILIKLADRLHNMRTLKHLPQEKQ RRISNETLEIFAPLAHRLGISKIKWELEDTALRYLNPQQYYRIVNLMKKKRAERELYV DEVVNEVKKRVEEVNIKADFSGRPKHIYSIYRKMVLQNKQFNEIYDLLAVRILVNSIK DCYAVLGIIHTCWKPMPGRFKDYIAMPKPNMYQSLHTTVIGPKGDPLEVQIRTFEMHE IAEYGVAAHWAYKEGKAANEGATFEKKLSWFREILEFQNESTDAEEFMESLKIDLFSD MVYVFTPKGDVIELPSGSVPIDFSYRIHSEIGNKTIGAKVNGKMVTLDHKLRTGDIVE ILTSKHSYGPSQDWVKLAQTSQAKHKIRQFFKKQRREENVEKGRELVEKEIKNLDFEL KDVLTPENIQKVADKFNFSNEEDMYAAVGYNGITALQVANRLTEKERKQRDQEEQEKI VQEVTGEPKPYPQGRKREAGVRVKGIDNLLVRLSKCCNPVPGDDIVGFITKGRGVSVH REDCPNVKTNEAQERLIPVEWEHESQVQKRKEYNVEIEILGYDRRGLLNEVLQAVNET KTNISSVSGKSDRNKVATIHMAIFIQNINHLHKVVERIKQIRDIYSVRRVMN*" /label="rsh CDS" gene complement(2444853..2447057) /gene="rsh" /locus_tag="BSU_27600" /old_locus_tag="BSU27600" /label="rsh gene" promotor_-10 complement(2447086..2447105) /Source="Nicolas_upshift_promotors" /id="U2130" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.648351648351648" /psig="0.998001998001998" /xcortree=2252 /SigmaFactorBS="taatatttggctatttgaacttctgcTCTTTACAtctttcgt ttttttCTTGATAATAAACTACAATAcagtttacattttaaaaaaggtgattccatgg c" /listShort="relA, dtd" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2447093) /Source="Nicolas_upshifts" /id="U2130" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.648351648351648" /psig="0.998001998001998" /xcortree=2252 /SigmaFactorBS="taatatttggctatttgaacttctgcTCTTTACAtctttcgt ttttttCTTGATAATAAACTACAATAcagtttacattttaaaaaaggtgattccatgg c" /listShort="relA, dtd" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2447095..2447185) /Source="Nicolas_S_feature" /locus_tag="new_2822771_2822861_c" /HighExp="Cold, G135, G180, G150, H2O2, Paraq, Oxctl, C30, LBGexp, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA, SigB" /TUshortPSig="0.951, 1, 1" /TUlongSig="SigA, SigA" /TUlongPSig="0.999, 1" /label="S1045" promotor_-35 complement(2447120..2447127) /Source="Nicolas_upshift_promotors" /id="U2130" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.648351648351648" /psig="0.998001998001998" /xcortree=2252 /SigmaFactorBS="taatatttggctatttgaacttctgcTCTTTACAtctttcgt ttttttCTTGATAATAAACTACAATAcagtttacattttaaaaaaggtgattccatgg c" /listShort="relA, dtd" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2447149 /Source="Nicolas_upshifts" /id="D1414" /incds=0 /nref=1 /ntot=14 /MaxReadThrough="1.75679" /MaxDrop="3.54336" /score="0.486890657" /energy="-12.7" /TU="NA" /idTUdmin="U2126" /TUdmin=2772 /isTUend="FALSE" /label="downshifts" CDS complement(2447225..2447737) /gene="apt" /locus_tag="BSU_27610" /old_locus_tag="BSU27610" /EC_number="2.4.2.7" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:6408059, 9383190, 15629952" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6408059, 9383190, 15629952; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="adenine phosphoribosyltransferase" /protein_id="NP_390639.1" /db_xref="EnsemblGenomes-Gn:BSU27610" /db_xref="EnsemblGenomes-Tr:CAB14720" /db_xref="GOA:O34443" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR005764" /db_xref="InterPro:IPR029057" /db_xref="SubtiList:BG12568" /db_xref="UniProtKB/Swiss-Prot:O34443" /translation="MDLKQYVTIVPDYPKEGVQFKDITTLMDKGDVYRYATDQIVEYA KEKQIDLVVGPEARGFIIGCPVAYALGVGFAPVRKEGKLPREVIKVDYGLEYGKDVLT IHKDAIKPGQRVLITDDLLATGGTIEATIKLVEELGGVVAGIAFLIELSYLDGRNKLE DYDILTLMKY*" /label="apt CDS" gene complement(2447225..2447737) /gene="apt" /locus_tag="BSU_27610" /old_locus_tag="BSU27610" /label="apt gene" downshifts complement(2447230) /Source="Nicolas_upshifts" /id="D1415" /incds=0 /nref=39 /ntot=228 /MaxReadThrough="5.36411" /MaxDrop="4.05036" /score="2.83935873" /energy="-6.8" /TU="U2131,U2132,U2133" /idTUdmin="U2131" /TUdmin="-115" /isTUend="FALSE" /label="downshifts" CDS complement(2447743..2450103) /gene="recJ" /locus_tag="BSU_27620" /old_locus_tag="BSU27620" /EC_number="3.1.-.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:21087930, 21170359, 26001966" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21087930, 21170359, 26001966; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="single-strand DNA-specific exonuclease" /protein_id="NP_390640.1" /db_xref="EnsemblGenomes-Gn:BSU27620" /db_xref="EnsemblGenomes-Tr:CAB14721" /db_xref="GOA:O32044" /db_xref="InterPro:IPR001667" /db_xref="InterPro:IPR003156" /db_xref="InterPro:IPR004610" /db_xref="InterPro:IPR018779" /db_xref="SubtiList:BG13804" /db_xref="UniProtKB/Swiss-Prot:O32044" /translation="MLASKMRWEIQRPDQDKVKSLTEQLHITPLVASLLVKRGFDTAE SARLFLHTKDADFYDPFEMKGMKEAADRIKQAISQQEKIMIYGDYDADGVTSTSVMLH TLQKLSAQVDFYIPDRFKEGYGPNEQAFRSIKERGFSLIITVDTGIAAVHEAKVAKEL GLDVIITDHHEPGPELPDVRAIVHPKQPGCTYPFKELAGVGVAFKLAHALLGELPDEL LDLAAIGTIADLVPLHDENRLIATLGLERLRRTNRLGLKELIKLSGGDIGEANEETVG FQLAPRLNAVGRIEQADPAVHLLMSEDSFEAEELAAEIDQLNKERQKMVSKMTDEAIE MVEQQGLDQTAIVVAKAGWNPGVVGIVASKLVDRFYRPAIVLGIDEEKGIAKGSARSI RGFNLFESLSECRDILPHFGGHPMAAGMTLKAEDVPDLRSRLNEIADNTLTEEDFIPV QEVDLVCGVEDITVESIAEMNMLSPFGMLNPKPHVLVENAVLEDVRKIGANKTHVKMT IRNESSQLDCVGFNKGELQEGIVPGSRISIVGEMSINEWNNRKKPQLMIKDAAVSEWQ LFDLRGKRTWEDTVSALPSAKRAIVSFKEDSTTLLQTEDLRREVHVISSKDQAKAFDL DGAYIVLLDPPPSLDMLARLLEGKAPERIYFIFLNHEDHFLSTFPARDHFKWYYAFLL KRGAFDVKKHGSELAKHKGWSVETINFMTKVFFDLGFVKIENGVLSVVSGAKKRDLTD SQTYQAKQQLMELDQKLNYSSAEELKEWLNKLMKQDSEAYESTRRT*" /label="recJ CDS" gene complement(2447743..2450103) /gene="recJ" /locus_tag="BSU_27620" /old_locus_tag="BSU27620" /label="recJ gene" promotor_-10 complement(2448207..2448226) /Source="Nicolas_upshift_promotors" /id="U2131" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.95104895104895" /psig="0.95104895104895" /xcortree=754 /SigmaFactorBS="tgcacgtcatcagttctaaagatcaaGCAAAGGCGTttgacc tcgatggTGCATATATTGTATTACTGGatccgccgccttcgctggacatgctcgcacg t" /listShort="apt, S1045" /listLong="relA, dtd" /label="promotor_-10" upshifts complement(2448215) /Source="Nicolas_upshifts" /id="U2131" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.95104895104895" /psig="0.95104895104895" /xcortree=754 /SigmaFactorBS="tgcacgtcatcagttctaaagatcaaGCAAAGGCGTttgacc tcgatggTGCATATATTGTATTACTGGatccgccgccttcgctggacatgctcgcacg t" /listShort="apt, S1045" /listLong="relA, dtd" /label="upshifts" promotor_-35 complement(2448240..2448249) /Source="Nicolas_upshift_promotors" /id="U2131" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.95104895104895" /psig="0.95104895104895" /xcortree=754 /SigmaFactorBS="tgcacgtcatcagttctaaagatcaaGCAAAGGCGTttgacc tcgatggTGCATATATTGTATTACTGGatccgccgccttcgctggacatgctcgcacg t" /listShort="apt, S1045" /listLong="relA, dtd" /label="promotor_-35" promotor_-10 complement(2450117..2450136) /Source="Nicolas_upshift_promotors" /id="U2132" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.493506493506494" /psig=1 /xcortree=2600 /SigmaFactorBS="gattgagaaaaaagactagttttcgaatattATTTGAAaccc ctcagcctgcTCTAGTATAATAGGGTGGTTgaggggtgaatttatgttagcgtcaaaa a" /listShort="recJ, apt, S1045, relA, dtd" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2450128) /Source="Nicolas_upshifts" /id="U2132" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.493506493506494" /psig=1 /xcortree=2600 /SigmaFactorBS="gattgagaaaaaagactagttttcgaatattATTTGAAaccc ctcagcctgcTCTAGTATAATAGGGTGGTTgaggggtgaatttatgttagcgtcaaaa a" /listShort="recJ, apt, S1045, relA, dtd" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2450151..2450157) /Source="Nicolas_upshift_promotors" /id="U2132" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.493506493506494" /psig=1 /xcortree=2600 /SigmaFactorBS="gattgagaaaaaagactagttttcgaatattATTTGAAaccc ctcagcctgcTCTAGTATAATAGGGTGGTTgaggggtgaatttatgttagcgtcaaaa a" /listShort="recJ, apt, S1045, relA, dtd" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2450170..2450493) /gene="yrvD" /locus_tag="BSU_27630" /old_locus_tag="BSU27630" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390641.1" /db_xref="EnsemblGenomes-Gn:BSU27630" /db_xref="EnsemblGenomes-Tr:CAB14722" /db_xref="GOA:O32045" /db_xref="InterPro:IPR010445" /db_xref="SubtiList:BG13803" /db_xref="UniProtKB/Swiss-Prot:O32045" /translation="MNKQWTIIFALIFTLIVAIFAVINVRSVEVDYLFGRSEWPLILV ILGSVLMGALIVFSVGIFQVMKLKREIKTLRKENRTAIHKQEDTHLADQTDTQDASAM IEKKD*" /label="yrvD CDS" gene complement(2450170..2450493) /gene="yrvD" /locus_tag="BSU_27630" /old_locus_tag="BSU27630" /label="yrvD gene" promotor_-10 complement(2450514..2450532) /Source="Nicolas_upshift_promotors" /id="U2133" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=175 /SigmaFactorBS="cagcaaagggagcttaacctagtgttaagccaTGTTTAAaac cagtcttgattGGGAAAGTTACCTCAATAAgaagtttgggggaaaagagaatgaataa a" /listShort="yrvD, recJ, apt, S1045" /listLong="relA, dtd" /label="promotor_-10" upshifts complement(2450525) /Source="Nicolas_upshifts" /id="U2133" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=175 /SigmaFactorBS="cagcaaagggagcttaacctagtgttaagccaTGTTTAAaac cagtcttgattGGGAAAGTTACCTCAATAAgaagtttgggggaaaagagaatgaataa a" /listShort="yrvD, recJ, apt, S1045" /listLong="relA, dtd" /label="upshifts" promotor_-35 complement(2450547..2450553) /Source="Nicolas_upshift_promotors" /id="U2133" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=175 /SigmaFactorBS="cagcaaagggagcttaacctagtgttaagccaTGTTTAAaac cagtcttgattGGGAAAGTTACCTCAATAAgaagtttgggggaaaagagaatgaataa a" /listShort="yrvD, recJ, apt, S1045" /listLong="relA, dtd" /label="promotor_-35" CDS complement(2450569..2451066) /gene="yrvC" /locus_tag="BSU_27640" /old_locus_tag="BSU27640" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14563871; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative potassium transport accessory component" /protein_id="NP_390642.1" /db_xref="EnsemblGenomes-Gn:BSU27640" /db_xref="EnsemblGenomes-Tr:CAB14723" /db_xref="GOA:O32046" /db_xref="InterPro:IPR006037" /db_xref="InterPro:IPR026278" /db_xref="InterPro:IPR036721" /db_xref="SubtiList:BG13802" /db_xref="UniProtKB/Swiss-Prot:O32046" /translation="MRVRESELPGIGQKVEMITRNRDKISIIIHHDGRRELYYFDEND HEECVASVQFDDAEARQMSAILGGMAYKPKALEQVESALDDLIIEWCKAEAGAPAIHQ TIGDLNVGQEYHVTVIAIVKKNQDKQLNPSSETVIDEGDTLVISGEGTGLKRLIREKL TAKGA*" /label="yrvC CDS" gene complement(2450569..2451066) /gene="yrvC" /locus_tag="BSU_27640" /old_locus_tag="BSU27640" /label="yrvC gene" S_feature complement(2451067..2451142) /Source="Nicolas_S_feature" /locus_tag="new_2826743_2826818_c" /HighExp="Oxctl, HiOs, G180, LBGexp, Paraq, G150, G135, H2O2, MG-0.2, Mal" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1046" promotor_-10 complement(2451136..2451155) /Source="Nicolas_upshift_promotors" /id="U2134" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.485514485514486" /psig="0.999000999001" /xcortree=2308 /SigmaFactorBS="cagggcagcctgttttttgaagtttcATTGAACTtaaaatag acattTGCTATAATGACATACGCTTacatttaaacatatatatggtgttaaaagtgtt t" /listShort="S1046, yrvC, yrvD, recJ" /listLong="apt, S1045, relA, dtd" /label="promotor_-10" upshifts complement(2451142) /Source="Nicolas_upshifts" /id="U2134" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.485514485514486" /psig="0.999000999001" /xcortree=2308 /SigmaFactorBS="cagggcagcctgttttttgaagtttcATTGAACTtaaaatag acattTGCTATAATGACATACGCTTacatttaaacatatatatggtgttaaaagtgtt t" /listShort="S1046, yrvC, yrvD, recJ" /listLong="apt, S1045, relA, dtd" /label="upshifts" promotor_-35 complement(2451169..2451176) /Source="Nicolas_upshift_promotors" /id="U2134" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.485514485514486" /psig="0.999000999001" /xcortree=2308 /SigmaFactorBS="cagggcagcctgttttttgaagtttcATTGAACTtaaaatag acattTGCTATAATGACATACGCTTacatttaaacatatatatggtgttaaaagtgtt t" /listShort="S1046, yrvC, yrvD, recJ" /listLong="apt, S1045, relA, dtd" /label="promotor_-35" CDS complement(2451224..2453437) /gene="secDF" /locus_tag="BSU_27650" /old_locus_tag="BSU27650" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9694879, 15941986, 15995216, 16517687" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9694879, 15941986, 15995216, 16517687; Product type t: transporter" /codon_start=1 /transl_table=11 /product="protein-export membrane protein" /protein_id="NP_390643.1" /db_xref="EnsemblGenomes-Gn:BSU27650" /db_xref="EnsemblGenomes-Tr:CAB14724" /db_xref="GOA:O32047" /db_xref="InterPro:IPR005665" /db_xref="InterPro:IPR005791" /db_xref="InterPro:IPR022645" /db_xref="InterPro:IPR022646" /db_xref="InterPro:IPR022813" /db_xref="SubtiList:BG12672" /db_xref="UniProtKB/Swiss-Prot:O32047" /translation="MKKGRLIAFFLFVLLIGTGLGYFTKPAANNITLGLDLQGGFEVL YDVQPVKKGDKITKDVLVSTVEALNRRANVLGVSEPNIQIEGNNRIRVQLAGVTNQNR AREILATEAQLSFRDANDKELLNGADLVENGAKQTYDSTTNEPIVTIKLKDADKFGEV TKKVMKMAPNNQLVIWLDYDKGDSFKKEVQKEHPKFVSAPNVSQELNTTDVKIEGHFT AQEAKDLASILNAGALPVKLTEKYSTSVGAQFGQQALHDTVFAGIVGIAIIFLFMLFY YRLPGLIAVITLSVYIYITLQIFDWMNAVLTLPGIAALILGVGMAVDANIITYERIKE ELKLGKSVRSAFRSGNRRSFATIFDANITTIIAAVVLFIFGTSSVKGFATMLILSILT SFITAVFLSRFLLALLVESRWLDRKKGWFGVNKKHIMDIQDTDENTEPHTPFQKWDFT SKRKYFFIFSSAVTVAGIIILLVFRLNLGIDFASGARIEVQSDHKLTTEQVEKDFESL GMDPDTVVLSGEKSNIGVARFVGVPDKETIAKVKTYFKDKYGSDPNVSTVSPTVGKEL ARNALYAVAIASIGIIIYVSIRFEYKMAIAAIASLLYDAFFIVTFFSITRLEVDVTFI AAILTIIGYSINDTIVTFDRVREHMKKRKPKTFADLNHIVNLSLQQTFTRSINTVLTV VIVVVTLLIFGASSITNFSIALLVGLLTGVYSSLYIAAQIWLAWKGRELKKDSAQ*" /label="secDF CDS" gene complement(2451224..2453437) /gene="secDF" /locus_tag="BSU_27650" /old_locus_tag="BSU27650" /label="secDF gene" downshifts complement(2451229) /Source="Nicolas_upshifts" /id="D1416" /incds=0 /nref=174 /ntot=249 /MaxReadThrough="4.49738" /MaxDrop="5.0013" /score="29.1843057" /energy="-17.8" /TU="U2137" /idTUdmin="U2137" /TUdmin="-1100" /isTUend="FALSE" /label="downshifts" promotor_-35 2452996..2453001 /Source="Nicolas_upshift_promotors" /id="U2135" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.625374625374625" /psig="0.987012987012987" /xcortree=604 /SigmaFactorBS="caccaaatttatcagcgtctttcagcttaatcgTGACAAttg gctcatttgtTGTGCTATCATAAGTTTGTTtagcgccgttttcgactagatcagcacc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2453015..2453034 /Source="Nicolas_upshift_promotors" /id="U2135" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.625374625374625" /psig="0.987012987012987" /xcortree=604 /SigmaFactorBS="caccaaatttatcagcgtctttcagcttaatcgTGACAAttg gctcatttgtTGTGCTATCATAAGTTTGTTtagcgccgttttcgactagatcagcacc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2453023 /Source="Nicolas_upshifts" /id="U2135" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.625374625374625" /psig="0.987012987012987" /xcortree=604 /SigmaFactorBS="caccaaatttatcagcgtctttcagcttaatcgTGACAAttg gctcatttgtTGTGCTATCATAAGTTTGTTtagcgccgttttcgactagatcagcacc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2453476..2453772) /gene="comN" /locus_tag="BSU_27660" /old_locus_tag="BSU27660" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:19028902, 27059541" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19028902, 27059541; Product type r: regulator" /codon_start=1 /transl_table=11 /product="post-transcriptional regulator" /protein_id="NP_390644.1" /db_xref="EnsemblGenomes-Gn:BSU27660" /db_xref="EnsemblGenomes-Tr:CAB14726" /db_xref="GOA:O32049" /db_xref="InterPro:IPR025716" /db_xref="SubtiList:BG13814" /db_xref="UniProtKB/Swiss-Prot:O32049" /translation="MEKHPADLYKDHVRPFLYSKLEEFKILGYDDVELESLWSYLTDK KWKKKTELSIYELASDILSVKIGEFMNYATVESFKTSNWLGSEEGQEALEELLR*" /label="comN CDS" gene complement(2453476..2453772) /gene="comN" /locus_tag="BSU_27660" /old_locus_tag="BSU27660" /label="comN gene" downshifts 2453683 /Source="Nicolas_upshifts" /id="D1417" /incds=1 /nref=1 /ntot=66 /MaxReadThrough="1.36122" /MaxDrop="2.33158" /score="-9.07145122" /energy="-8.4" /TU="NA" /idTUdmin="U2136" /TUdmin="-2508" /isTUend="FALSE" /label="downshifts" S_feature complement(2453773..2453851) /Source="Nicolas_S_feature" /locus_tag="new_2829449_2829527_c" /HighExp="LBGtran, Lbtran, C90, M40t45, HiOs, Lbexp, Cold, M0t45, UNK1, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigH" /TUlongPSig=1 /label="S1047" promotor_-35 2453813..2453818 /Source="Nicolas_upshift_promotors" /id="U2136" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=986 /SigmaFactorBS="tccacgctccttttttattgtttttcaagaagacttGTCATG cttggacgacatatacGCATATCTTTATTGTATATgattccaggtagtttgagaaggc a" /listShort="spoVB, S1049" /listLong="yrzE" /label="promotor_-35" promotor_-10 2453835..2453853 /Source="Nicolas_upshift_promotors" /id="U2136" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=986 /SigmaFactorBS="tccacgctccttttttattgtttttcaagaagacttGTCATG cttggacgacatatacGCATATCTTTATTGTATATgattccaggtagtttgagaaggc a" /listShort="spoVB, S1049" /listLong="yrzE" /label="promotor_-10" promotor_-10 complement(2453837..2453856) /Source="Nicolas_upshift_promotors" /id="U2137" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.787212787212787" /psig=1 /xcortree=2330 /SigmaFactorBS="ctttaaaaacgtctgtttcgccatttttaccccctgcCTTCt caaactacctggaATCATATACAATAAAGATATgcgtatatgtcgtccaagcatgaca a" /listShort="S1047, comN, secDF, S1046, yrvC, yrvD" /listLong="recJ, apt, S1045, relA, dtd" /label="promotor_-10" upshifts 2453837 /Source="Nicolas_upshifts" /id="U2136" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=986 /SigmaFactorBS="tccacgctccttttttattgtttttcaagaagacttGTCATG cttggacgacatatacGCATATCTTTATTGTATATgattccaggtagtttgagaaggc a" /listShort="spoVB, S1049" /listLong="yrzE" /label="upshifts" upshifts complement(2453851) /Source="Nicolas_upshifts" /id="U2137" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.787212787212787" /psig=1 /xcortree=2330 /SigmaFactorBS="ctttaaaaacgtctgtttcgccatttttaccccctgcCTTCt caaactacctggaATCATATACAATAAAGATATgcgtatatgtcgtccaagcatgaca a" /listShort="S1047, comN, secDF, S1046, yrvC, yrvD" /listLong="recJ, apt, S1045, relA, dtd" /label="upshifts" S_feature complement(2453853..2454771) /Source="Nicolas_S_feature" /locus_tag="new_2829529_2830447_c" /HighExp="S2, M9-stat, Lbstat, BC, T2.0H, T3.0H, T2.30H, T3.30H, Cold, M0t90" /AntisenseName="spoVB" /AntisenseCor="-8.5173616652496897E-2" /AntisenseRegPval="-0.8" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1048" promotor_-35 complement(2453871..2453874) /Source="Nicolas_upshift_promotors" /id="U2137" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.787212787212787" /psig=1 /xcortree=2330 /SigmaFactorBS="ctttaaaaacgtctgtttcgccatttttaccccctgcCTTCt caaactacctggaATCATATACAATAAAGATATgcgtatatgtcgtccaagcatgaca a" /listShort="S1047, comN, secDF, S1046, yrvC, yrvD" /listLong="recJ, apt, S1045, relA, dtd" /label="promotor_-35" CDS 2453888..2455444 /gene="spoVB" /locus_tag="BSU_27670" /old_locus_tag="BSU27670" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:1744050, 15292147, 15849754, 16850406, 17714441, 19648239" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1744050, 15292147, 15849754, 16850406, 17714441, 19648239; Product type t : transporter" /codon_start=1 /transl_table=11 /product="involved in spore cortex synthesis (stage V sporulation); translocase with flippase function for peptidoglycan synthesis" /protein_id="NP_390645.1" /db_xref="EnsemblGenomes-Gn:BSU27670" /db_xref="EnsemblGenomes-Tr:CAB14727" /db_xref="GOA:Q00758" /db_xref="InterPro:IPR002797" /db_xref="InterPro:IPR014249" /db_xref="InterPro:IPR024923" /db_xref="InterPro:IPR029303" /db_xref="SubtiList:BG10778" /db_xref="UniProtKB/Swiss-Prot:Q00758" /translation="MAKQTFLKGTLILIAAGMVTRMLGFVNRVVIARFIGEEGVGLYM MAAPTFFLATTLTQFGLPVAISKLVAEASARGDHQKTKNILVMSLTITGVLSLIFTPL FLFFAPVMAETMLTDKRTLYPLLAITPVVPIIAISSVLRGYFQGKQNMNPLAMSQVLE QVVRISLVAVCTTIFLPYGIEYAAAGAMLSSVAGELASLLYLFVCFKYKKTIKIRKHF LQSIKNGKQTFTQLMSVSLPTTGSRFIGNLSWFFEPIVVAQSLAIAGVATVAATKQYG ELTGFAMTLLTLPSFITYSLSTALVPAISEGMEQKKLQVVEYRLEQAMRLCLLSGGIS VVILFVFADELMRVMYGSSGAAVFIKVMAPFFLLYYFQGPLQAVLQALNLAGAAMMNS LIGALVKTGLIFVLATRPSLGIMGAALAIVTGMVLVTLLHAATVSKVLPISIKIKEYA LSFAVIVICGFISSAIKQYISFGASEAVNLAGWIAASAAIYMILLLVFRLIKKDELRR IPIIGRLIIR*" /label="spoVB CDS" gene 2453888..2455444 /gene="spoVB" /locus_tag="BSU_27670" /old_locus_tag="BSU27670" /label="spoVB gene" promotor_-10 complement(2454757..2454775) /Source="Nicolas_upshift_promotors" /id="U2138" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=549 /SigmaFactorBS="acctgcaattttttctgctccattccttcactgatcGCAGGA ACAagcgcggtcgaCAAAGAATATGTAATAAAGctgggcagagtcagcagcgtcatgg c" /listShort="S1048" /listLong="S1047, comN, secDF" /label="promotor_-10" upshifts complement(2454771) /Source="Nicolas_upshifts" /id="U2138" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=549 /SigmaFactorBS="acctgcaattttttctgctccattccttcactgatcGCAGGA ACAagcgcggtcgaCAAAGAATATGTAATAAAGctgggcagagtcagcagcgtcatgg c" /listShort="S1048" /listLong="S1047, comN, secDF" /label="upshifts" promotor_-35 complement(2454787..2454795) /Source="Nicolas_upshift_promotors" /id="U2138" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=549 /SigmaFactorBS="acctgcaattttttctgctccattccttcactgatcGCAGGA ACAagcgcggtcgaCAAAGAATATGTAATAAAGctgggcagagtcagcagcgtcatgg c" /listShort="S1048" /listLong="S1047, comN, secDF" /label="promotor_-35" S_feature 2455445..2456209 /Source="Nicolas_S_feature" /locus_tag="new_2831121_2831885" /HighExp="S3, BT, S4, LoTm, S7, S8, T5.0H, T4.0H, M9-stat, T3.30H" /AntisenseName="yrbG" /AntisenseCor="0.65629957843767395" /AntisenseRegPval="-33.799999999999997" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1049" CDS complement(2455448..2456104) /gene="yrbG" /locus_tag="BSU_27680" /old_locus_tag="BSU27680" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_390646.1" /db_xref="EnsemblGenomes-Gn:BSU27680" /db_xref="EnsemblGenomes-Tr:CAB14728" /db_xref="GOA:O32050" /db_xref="InterPro:IPR007353" /db_xref="InterPro:IPR023090" /db_xref="SubtiList:BG13786" /db_xref="UniProtKB/Swiss-Prot:O32050" /translation="MEELLTIAFRTVVLYFVILVIFRFMGKREIGELSILDLVVFIMM AEIAVLAIENVDDHLFHTILPMLVLMIIQVTLAYFSLKNRKVRQLLDGKPTIIIKYGK IDEEAMKSQRYNFDDLMVQLRENSIDRVADVSFAILEPSGKLTIVKKENSGEHRQLEM PLIIDGFIQTENLSRISKDRKWLLESLQKHGYTNPSDISFCSFTDGEIYIDEKDGHRT *" /label="yrbG CDS" gene complement(2455448..2456104) /gene="yrbG" /locus_tag="BSU_27680" /old_locus_tag="BSU27680" /label="yrbG gene" promotor_-10 complement(2456123..2456134) /Source="Nicolas_upshift_promotors" /id="U2139" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=940 /SigmaFactorBS="aattagacgtaaaagctttgtgaaatgcaatcggtttttctT ACATAAattgatcattttgTTGCAACCTATAatgagttggaggtgcataatggaagag c" /listShort="yrbG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2456135) /Source="Nicolas_upshifts" /id="U2139" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=940 /SigmaFactorBS="aattagacgtaaaagctttgtgaaatgcaatcggtttttctT ACATAAattgatcattttgTTGCAACCTATAatgagttggaggtgcataatggaagag c" /listShort="yrbG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2456148..2456154) /Source="Nicolas_upshift_promotors" /id="U2139" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=940 /SigmaFactorBS="aattagacgtaaaagctttgtgaaatgcaatcggtttttctT ACATAAattgatcattttgTTGCAACCTATAatgagttggaggtgcataatggaagag c" /listShort="yrbG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2456187..2456192 /Source="Nicolas_upshift_promotors" /id="U2140" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=977 /SigmaFactorBS="tgtaagaaaaaccgattgcatttcacaaagcttttaCGTCTA attcatgggataaggGAATACATTTTTACAAAGAcgagccatcagcatgtctgacggt t" /listShort="yrzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2456208..2456226 /Source="Nicolas_upshift_promotors" /id="U2140" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=977 /SigmaFactorBS="tgtaagaaaaaccgattgcatttcacaaagcttttaCGTCTA attcatgggataaggGAATACATTTTTACAAAGAcgagccatcagcatgtctgacggt t" /listShort="yrzE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2456211 /Source="Nicolas_upshifts" /id="U2140" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=977 /SigmaFactorBS="tgtaagaaaaaccgattgcatttcacaaagcttttaCGTCTA attcatgggataaggGAATACATTTTTACAAAGAcgagccatcagcatgtctgacggt t" /listShort="yrzE" /GFF_Attribute="listLong" /label="upshifts" CDS 2456239..2456691 /gene="yrzE" /locus_tag="BSU_27690" /old_locus_tag="BSU27690" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_390647.1" /db_xref="EnsemblGenomes-Gn:BSU27690" /db_xref="EnsemblGenomes-Tr:CAB14729" /db_xref="GOA:O32051" /db_xref="InterPro:IPR023804" /db_xref="SubtiList:BG13815" /db_xref="UniProtKB/Swiss-Prot:O32051" /translation="MSDGFEQKEQKPFNTGREETIMEETKQVGKGILYGLIAIFSAML LTSLAVSLLLTATSLEESSFNWLITAISFLSLFIGGFISGGKGKERGWMIGALTALSF SLIILLFQYLGFGKTFTAEQLIFHLGFLGVCMLGGIFGVNMRGNRSST*" /label="yrzE CDS" gene 2456239..2456691 /gene="yrzE" /locus_tag="BSU_27690" /old_locus_tag="BSU27690" /label="yrzE gene" downshifts 2456675 /Source="Nicolas_upshifts" /id="D1418" /incds=0 /nref=39 /ntot=61 /MaxReadThrough="1.45569" /MaxDrop="7.7199" /score="41.7975947" /energy="-15" /TU="NA" /idTUdmin="U2140" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2456730) /Source="Nicolas_upshifts" /id="D1419" /incds=0 /nref=188 /ntot=281 /MaxReadThrough="2.20451" /MaxDrop="7.91954" /score="33.5938356" /energy="-15" /TU="NA" /idTUdmin="U2141" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2456748..2457014) /gene="yrbF" /locus_tag="BSU_27700" /old_locus_tag="BSU27700" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10974125, 16166550, 21235483, 26790414; Product type t: transporter" /codon_start=1 /transl_table=11 /product="component of the preprotein translocase" /protein_id="NP_390648.2" /db_xref="EnsemblGenomes-Gn:BSU27700" /db_xref="EnsemblGenomes-Tr:CAB14730" /db_xref="GOA:O32052" /db_xref="InterPro:IPR003849" /db_xref="SubtiList:BG13785" /db_xref="UniProtKB/Swiss-Prot:O32052" /translation="MTGTLGTLVPIILMFAVLYFLLIRPQQKQQKAVRQMQEELKKGD SVVTIGGLHGTVDSIDESKVVIKTGDNTRLTFDRRAIREVSAAE*" /label="yrbF CDS" gene complement(2456748..2457014) /gene="yrbF" /locus_tag="BSU_27700" /old_locus_tag="BSU27700" /label="yrbF gene" CDS complement(2457051..2458196) /gene="tgt" /locus_tag="BSU_27710" /old_locus_tag="BSU27710" /EC_number="2.4.2.29" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12123838, 14660578, 16199558, 16206323; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA-guanine transglycosylase" /protein_id="NP_390649.1" /db_xref="EnsemblGenomes-Gn:BSU27710" /db_xref="EnsemblGenomes-Tr:CAB14731" /db_xref="GOA:O32053" /db_xref="InterPro:IPR002616" /db_xref="InterPro:IPR004803" /db_xref="InterPro:IPR036511" /db_xref="SubtiList:BG12686" /db_xref="UniProtKB/Swiss-Prot:O32053" /translation="MAEQPIRYEFIKECKQTGARLGKVHTPHGSFETPVFMPVGTLAT VKTMSPEELKAMDAGIILSNTYHLWLRPGQDIVKEAGGLHKFMNWDRAILTDSGGFQV FSLSKFRNIEEEGVHFRNHLNGDKLFLSPEKAMEIQNALGSDIMMAFDECPPYPAEYD YMKRSVERTSRWAERCLNAHNRQDEQGLFGIVQGGEYEDLRTQSAKDLISLDFPGYAI GGLSVGEPKDVMNRVLEFTTPLLPKDKPRYLMGVGSPDALIDGAIRGVDMFDCVLPTR IARNGTVFTAEGRLNMKNAKFERDFRPIDEECDCYTCKNYTRAYIRHLIRCNETFGLR LTTYHNLHFLLHLMEQVRQAIREDRLGDFREEFFERYGYNKPNAKSF*" /label="tgt CDS" gene complement(2457051..2458196) /gene="tgt" /locus_tag="BSU_27710" /old_locus_tag="BSU27710" /label="tgt gene" upshifts complement(2457103) /Source="Nicolas_upshifts" /id="U2141" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.432567432567433" /psig="0.164835164835165" /xcortree=2327 /SigmaFactorBS="tacacttaatggagcaggtaagacaggctattcgcgaggatc gtctgggtgatttcaGagaagagttctttgagcgttacggctataacaagccaaatgc g" /listShort="yrbF" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2457147) /Source="Nicolas_upshifts" /id="U2142" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.380619380619381" /psig="0.98901098901099" /xcortree=2457 /SigmaFactorBS="attcggccttcgattaacaACTTACcataaccttcatttTCT GTTACACTTAATGGAGCaggtaagacaggctattcgcgaggatcgtctgggtgatttc a" /listShort="yrbF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2457149..2457168) /Source="Nicolas_upshift_promotors" /id="U2142" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.380619380619381" /psig="0.98901098901099" /xcortree=2457 /SigmaFactorBS="attcggccttcgattaacaACTTACcataaccttcatttTCT GTTACACTTAATGGAGCaggtaagacaggctattcgcgaggatcgtctgggtgatttc a" /listShort="yrbF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2457183..2457188) /Source="Nicolas_upshift_promotors" /id="U2142" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.380619380619381" /psig="0.98901098901099" /xcortree=2457 /SigmaFactorBS="attcggccttcgattaacaACTTACcataaccttcatttTCT GTTACACTTAATGGAGCaggtaagacaggctattcgcgaggatcgtctgggtgatttc a" /listShort="yrbF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2458223..2459251) /gene="queA" /locus_tag="BSU_27720" /old_locus_tag="BSU27720" /EC_number="2.4.99.17" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 15822125, 17083917, 10739928" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 15822125, 17083917, 10739928; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="S-adenosylmethionine tRNA ribosyltransferase-isomerase" /protein_id="NP_390650.1" /db_xref="EnsemblGenomes-Gn:BSU27720" /db_xref="EnsemblGenomes-Tr:CAB14732" /db_xref="GOA:O32054" /db_xref="InterPro:IPR003699" /db_xref="InterPro:IPR036100" /db_xref="PDB:1YY3" /db_xref="SubtiList:BG12662" /db_xref="UniProtKB/Swiss-Prot:O32054" /translation="MKVDLFDFELPERLIAQVPLEQRDASRLMVLDKHTGELTDSSFK HIISFFNEGDCLVLNNTRVLPARLFGTKEDTGAKVELLLLKQETGDKWETLAKPAKRV KKGTVVTFGDGRLKAICTEELEHGGRKMEFQYDGIFYEVLESLGEMPLPPYIKEQLDD KERYQTVYSKEIGSAAAPTAGLHFTEEILQQLKDKGVQIEFITLHVGLGTFRPVSADE VEEHNMHAEFYQMSEETAAALNKVRENGGRIISVGTTSTRTLETIAGEHDGQFKASSG WTSIFIYPGYEFKAIDGMITNFHLPKSSLIMLVSALAGRENILRAYNHAVEEEYRFFS FGDAMLII*" /label="queA CDS" gene complement(2458223..2459251) /gene="queA" /locus_tag="BSU_27720" /old_locus_tag="BSU27720" /label="queA gene" CDS complement(2459281..2459481) /gene="yrzS" /locus_tag="BSU_27729" /old_locus_tag="BSU27729" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="YP_003097768.1" /db_xref="EnsemblGenomes-Gn:BSU27729" /db_xref="EnsemblGenomes-Tr:CAX52674" /db_xref="GOA:C0H463" /db_xref="InterPro:IPR021320" /db_xref="UniProtKB/Swiss-Prot:C0H463" /translation="MTEFPKIIMILGAVLLIIGAVLHFVGKMPGDIFVKKGNVTFFFP VVTCIIISVVLSILLNLFGRMK*" /label="yrzS CDS" gene complement(2459281..2459481) /gene="yrzS" /locus_tag="BSU_27729" /old_locus_tag="BSU27729" /label="yrzS gene" CDS complement(2459474..2460478) /gene="ruvB" /locus_tag="BSU_27730" /old_locus_tag="BSU27730" /EC_number="3.1.22.4" /function="16.6: Maintain" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14701911, 15317759, 16267290, 19422832, 21600217, 24770420; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="Holliday junction DNA helicase, ATP-dependent component" /protein_id="YP_054590.1" /db_xref="EnsemblGenomes-Gn:BSU27730" /db_xref="EnsemblGenomes-Tr:CAB14733" /db_xref="GOA:O32055" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004605" /db_xref="InterPro:IPR008823" /db_xref="InterPro:IPR008824" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12669" /db_xref="UniProtKB/Swiss-Prot:O32055" /translation="MDERLVSSEADNHESVIEQSLRPQNLAQYIGQHKVKENLRVFID AAKMRQETLDHVLLYGPPGLGKTTLASIVANEMGVELRTTSGPAIERPGDLAAILTAL EPGDVLFIDEIHRLHRSIEEVLYPAMEDFCLDIVIGKGPSARSVRLDLPPFTLVGATT RVGLLTAPLRDRFGVMSRLEYYTQEELADIVTRTADVFEVEIDKPSALEIARRSRGTP RVANRLLRRVRDFAQVLGDSRITEDISQNALERLQVDRLGLDHIDHKLLMGMIEKFNG GPVGLDTISATIGEESHTIEDVYEPYLLQIGFIQRTPRGRIVTPAVYHHFQMEAPRYD *" /label="ruvB CDS" gene complement(2459474..2460478) /gene="ruvB" /locus_tag="BSU_27730" /old_locus_tag="BSU27730" /label="ruvB gene" CDS complement(2460489..2461094) /gene="ruvA" /locus_tag="BSU_27740" /old_locus_tag="BSU27740" /EC_number="3.1.22.4" /function="16.9: Replicate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14701911, 15317759, 16267290, 24770420" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14701911, 15317759, 16267290, 24770420; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Holliday junction DNA helicase" /protein_id="NP_390652.1" /db_xref="EnsemblGenomes-Gn:BSU27740" /db_xref="EnsemblGenomes-Tr:CAB14734" /db_xref="GOA:O05392" /db_xref="InterPro:IPR000085" /db_xref="InterPro:IPR003583" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR011114" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR013849" /db_xref="InterPro:IPR036267" /db_xref="SubtiList:BG11973" /db_xref="UniProtKB/Swiss-Prot:O05392" /translation="MIEFVKGTIDYVSPQYIVIENGGIGYQIFTPNPFIYKERSQETI FTYHHIREDAFSLYGFSTREEKALFTKLLNVTGIGPKGALAILGSGDPGAVIQAIENE DEAFLVKFPGVGKKTARQIILDLKGKLADVVPEMIENLFNHEERLEKQTAETALEEAL EALRVLGYAEKEIKKVLPHLKEEIGLTTDQYVKKALQKLLK*" /label="ruvA CDS" gene complement(2460489..2461094) /gene="ruvA" /locus_tag="BSU_27740" /old_locus_tag="BSU27740" /label="ruvA gene" promotor_-10 complement(2461113..2461132) /Source="Nicolas_upshift_promotors" /id="U2143" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=2553 /SigmaFactorBS="aaagaatgagagagaagcgaacatatgttaacttttctatAA GACTTtggctgttttTATGGTACAATGAAGAACAGtcaaagaggtgaatttgcgtgat t" /listShort="ruvA, ruvB, yrzS, queA, tgt, yrbF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2461129) /Source="Nicolas_upshifts" /id="U2143" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=2553 /SigmaFactorBS="aaagaatgagagagaagcgaacatatgttaacttttctatAA GACTTtggctgttttTATGGTACAATGAAGAACAGtcaaagaggtgaatttgcgtgat t" /listShort="ruvA, ruvB, yrzS, queA, tgt, yrbF" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2461131..2461232) /Source="Nicolas_S_feature" /locus_tag="new_2836807_2836908_c" /HighExp="Etha, Heat, S8, S7, S4, S3, S6, S5, Salt, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigB" /TUshortPSig="0.997, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1050" promotor_-35 complement(2461143..2461149) /Source="Nicolas_upshift_promotors" /id="U2143" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=2553 /SigmaFactorBS="aaagaatgagagagaagcgaacatatgttaacttttctatAA GACTTtggctgttttTATGGTACAATGAAGAACAGtcaaagaggtgaatttgcgtgat t" /listShort="ruvA, ruvB, yrzS, queA, tgt, yrbF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2461233..2461745) /gene="bofC" /locus_tag="BSU_27750" /old_locus_tag="BSU27750" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10931291, 16049010" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10931291, 16049010; Product type f: factor" /codon_start=1 /transl_table=11 /product="bypass of forespore C, intercompartmental signaling factor" /protein_id="NP_390653.1" /db_xref="EnsemblGenomes-Gn:BSU27750" /db_xref="EnsemblGenomes-Tr:CAB14735" /db_xref="GOA:O05391" /db_xref="InterPro:IPR015050" /db_xref="InterPro:IPR015071" /db_xref="PDB:2BW2" /db_xref="SubtiList:BG11917" /db_xref="UniProtKB/Swiss-Prot:O05391" /translation="MKRFSTAYLLLGILCSAAVFLIGAPSRALGAEVEHYEPLQVHVQ LEKVYLDGDVSIEHKHEKVFSMDDFWAAYAGWTLVEQKKGYVLFRKQMDDISPLSKVN GYIGVSDNGVISTFHGRPEPASEPIQSFFQIDLERLESHMQKNLLKGIPFRTKAEFED VIEHMKTYSG*" /label="bofC CDS" gene complement(2461233..2461745) /gene="bofC" /locus_tag="BSU_27750" /old_locus_tag="BSU27750" /label="bofC gene" promotor_-10 complement(2461774..2461785) /Source="Nicolas_upshift_promotors" /id="U2144" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1133 /SigmaFactorBS="gaacggtttgtcagggaaaatgtgcagacaaattttgataaa aCGGTTAAgcagtagcctctttGGTCAAACTAATcataaacgtgtgcaaagaggtgta g" /listShort="bofC, S1050, ruvA, ruvB" /listLong="yrzS, queA, tgt, yrbF" /label="promotor_-10" upshifts complement(2461789) /Source="Nicolas_upshifts" /id="U2144" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1133 /SigmaFactorBS="gaacggtttgtcagggaaaatgtgcagacaaattttgataaa aCGGTTAAgcagtagcctctttGGTCAAACTAATcataaacgtgtgcaaagaggtgta g" /listShort="bofC, S1050, ruvA, ruvB" /listLong="yrzS, queA, tgt, yrbF" /label="upshifts" CDS complement(2461793..2463100) /gene="csbX" /locus_tag="BSU_27760" /old_locus_tag="BSU27760" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9099855, 14638426, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative catecholate siderophose exporter" /protein_id="NP_390654.2" /db_xref="EnsemblGenomes-Gn:BSU27760" /db_xref="EnsemblGenomes-Tr:CAB14736" /db_xref="GOA:O05390" /db_xref="InterPro:IPR004748" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11922" /db_xref="UniProtKB/Swiss-Prot:O05390" /translation="MNTVHAKGNVLNKIGIPSHMVWGYIGVVIFMVGDGLEQGWLSPF LVDHGLSMQQSASLFTMYGIAVTISAWLSGTFVQTWGPRKTMTVGLLAFILGSAAFIG WAIPHMYYPALLGSYALRGLGYPLFAYSFLVWVSYSTSQNILGKAVGWFWFMFTCGLN VLGPFYSSYAVPAFGEINTLWSALLFVAAGGILALFFNKDKFTPIQKQDQPKWKELSK AFTIMFENPKVGIGGVVKTINAIGQFGFAIFLPTYLARYGYSVSEWLQIWGTLFFVNI VFNIIFGAVGDKLGWRNTVMWFGGVGCGIFTLALYYTPQLIGHQYWVLMIIACCYGAA LAGYVPLSALLPTLAPDNKGAAMSVLNLGSGLCAFIAPGIVSLFIGPLGAGGVIWIFA ALYFFSAFLTRFLTISEQSTDVYTEERFVRENVQTNFDKTVKQ*" /label="csbX CDS" gene complement(2461793..2463100) /gene="csbX" /locus_tag="BSU_27760" /old_locus_tag="BSU27760" /label="csbX gene" promotor_-35 complement(2461800..2461806) /Source="Nicolas_upshift_promotors" /id="U2144" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1133 /SigmaFactorBS="gaacggtttgtcagggaaaatgtgcagacaaattttgataaa aCGGTTAAgcagtagcctctttGGTCAAACTAATcataaacgtgtgcaaagaggtgta g" /listShort="bofC, S1050, ruvA, ruvB" /listLong="yrzS, queA, tgt, yrbF" /label="promotor_-35" downshifts complement(2463054) /Source="Nicolas_upshifts" /id="D1420" /incds=0 /nref=2 /ntot=80 /MaxReadThrough="7.18585" /MaxDrop="3.0235" /score="-6.29978124" /energy="-14.3" /TU="U2145,U2146" /idTUdmin="U2146" /TUdmin="-1793" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2463124..2463142) /Source="Nicolas_upshift_promotors" /id="U2145" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=262 /SigmaFactorBS="ttgagcacactgaaaaaatcgctttttaatctaacaGGATTA CaattcagcaagcttGGGTATATACTCCATTGATactttaagtaggcggtggagaaaa t" /listShort="csbX, bofC, S1050, ruvA, ruvB, yrzS, queA, tgt" /listLong="yrbF" /label="promotor_-10" upshifts complement(2463139) /Source="Nicolas_upshifts" /id="U2145" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=262 /SigmaFactorBS="ttgagcacactgaaaaaatcgctttttaatctaacaGGATTA CaattcagcaagcttGGGTATATACTCCATTGATactttaagtaggcggtggagaaaa t" /listShort="csbX, bofC, S1050, ruvA, ruvB, yrzS, queA, tgt" /listLong="yrbF" /label="upshifts" promotor_-35 complement(2463157..2463163) /Source="Nicolas_upshift_promotors" /id="U2145" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=262 /SigmaFactorBS="ttgagcacactgaaaaaatcgctttttaatctaacaGGATTA CaattcagcaagcttGGGTATATACTCCATTGATactttaagtaggcggtggagaaaa t" /listShort="csbX, bofC, S1050, ruvA, ruvB, yrzS, queA, tgt" /listLong="yrbF" /label="promotor_-35" CDS complement(2463171..2464196) /gene="yrbE" /locus_tag="BSU_27770" /old_locus_tag="BSU27770" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 28043209; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative inositol-related oxidoreductase" /protein_id="NP_390655.1" /db_xref="EnsemblGenomes-Gn:BSU27770" /db_xref="EnsemblGenomes-Tr:CAB14737" /db_xref="GOA:O05389" /db_xref="InterPro:IPR000683" /db_xref="InterPro:IPR004104" /db_xref="InterPro:IPR030827" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12280" /db_xref="UniProtKB/Swiss-Prot:O05389" /translation="MTKQIVTGIIGAGRIGKLHVQNISRIPHMKIKAISDIQASRIKS WADSHQIEYITSDYRDLLHDPDIDAIFICSPTAVHAQMIKEAAEAKKHIFCEKPVSFS LDETSEALAAVRKHGVTLQVGFNRRFDPHFKKIKTIVENGEIGTPHLLKITSRDPEPP NIDYVRTSGGLFMDMSIHDFDMARYIMGSEVTEVYAKGAALVNPSFAELGDIDTAVIT LTFENGAMAVIDNSRQAVYGYDQRVEVFGTKGSAAADNSRPTTVEVSTADFVMKDKPH FFFLERYKDSYEEEILRFAEAIGTNQETPCTGNDGLQAGRIARAAQQSLAFGMPVSIE HTEKIAF*" /label="yrbE CDS" gene complement(2463171..2464196) /gene="yrbE" /locus_tag="BSU_27770" /old_locus_tag="BSU27770" /label="yrbE gene" promotor_-10 complement(2464233..2464252) /Source="Nicolas_upshift_promotors" /id="U2146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=328 /SigmaFactorBS="gaattgtgataaaagagacatagaacgtttaatttccatTCT TGAAAagcgcttacaaatgGGATAGTATTAATTTTAAATaaagcgctttcgtgaatga t" /listShort="yrbE, csbX, bofC" /listLong="S1050, ruvA, ruvB" /label="promotor_-10" upshifts complement(2464253) /Source="Nicolas_upshifts" /id="U2146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=328 /SigmaFactorBS="gaattgtgataaaagagacatagaacgtttaatttccatTCT TGAAAagcgcttacaaatgGGATAGTATTAATTTTAAATaaagcgctttcgtgaatga t" /listShort="yrbE, csbX, bofC" /listLong="S1050, ruvA, ruvB" /label="upshifts" promotor_-35 complement(2464267..2464274) /Source="Nicolas_upshift_promotors" /id="U2146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=328 /SigmaFactorBS="gaattgtgataaaagagacatagaacgtttaatttccatTCT TGAAAagcgcttacaaatgGGATAGTATTAATTTTAAATaaagcgctttcgtgaatga t" /listShort="yrbE, csbX, bofC" /listLong="S1050, ruvA, ruvB" /label="promotor_-35" promotor_-35 2464322..2464329 /Source="Nicolas_upshift_promotors" /id="U2147" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig="0.997002997002997" /xcortree=1538 /SigmaFactorBS="ctatgtctcttttatcacaattcatgcttatAAGTAGCCttc ttcttcaagaCCAGATACACTAGAATTAGGctctttttcctgaacagtttatgatttt c" /listShort="yrzF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2464343..2464362 /Source="Nicolas_upshift_promotors" /id="U2147" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig="0.997002997002997" /xcortree=1538 /SigmaFactorBS="ctatgtctcttttatcacaattcatgcttatAAGTAGCCttc ttcttcaagaCCAGATACACTAGAATTAGGctctttttcctgaacagtttatgatttt c" /listShort="yrzF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2464351 /Source="Nicolas_upshifts" /id="U2147" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig="0.997002997002997" /xcortree=1538 /SigmaFactorBS="ctatgtctcttttatcacaattcatgcttatAAGTAGCCttc ttcttcaagaCCAGATACACTAGAATTAGGctctttttcctgaacagtttatgatttt c" /listShort="yrzF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2464383..2464388 /Source="Nicolas_upshift_promotors" /id="U2148" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1056 /SigmaFactorBS="tcaagaccagatacactagaattaggctctttttcctgaaca gtttATGATTttcctataaacagctGCATAAAATAGAGCAAAGAaggtgaatgaaatg c" /listShort="yrzF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2464397 /Source="Nicolas_upshifts" /id="U2148" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1056 /SigmaFactorBS="tcaagaccagatacactagaattaggctctttttcctgaaca gtttATGATTttcctataaacagctGCATAAAATAGAGCAAAGAaggtgaatgaaatg c" /listShort="yrzF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2464404..2464422 /Source="Nicolas_upshift_promotors" /id="U2148" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1056 /SigmaFactorBS="tcaagaccagatacactagaattaggctctttttcctgaaca gtttATGATTttcctataaacagctGCATAAAATAGAGCAAAGAaggtgaatgaaatg c" /listShort="yrzF" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2464434..2465081 /gene="yrzF" /locus_tag="BSU_27785" /old_locus_tag="BSU27785" /EC_number="2.7.11.1" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative serine/threonine-protein kinase" /protein_id="NP_390656.2" /db_xref="EnsemblGenomes-Gn:BSU27785" /db_xref="EnsemblGenomes-Tr:CAB14738" /db_xref="GOA:O32057" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR017441" /db_xref="SubtiList:BG13816" /db_xref="UniProtKB/Swiss-Prot:O32057" /translation="MLTKAEALAHTVIYRKNSRFDKVKEKSEELTLIGKGRSAYVFAL TEGGRKMALKVFFPEYQATAVKEAAIYEKLAGSAFYPDIYETGDSFILMEYIKGETFY NCLKKGIAISDDMIQQVEEALSDARAAGLNPSDIHLRNLILTETGAVRVIDVARFEQT KTCTQWDDLKSAYHALYKKPIFPKKIPGFWLEIIAFLYKKDWFQKHFAQRKRKYS*" /label="yrzF CDS" gene 2464434..2465081 /gene="yrzF" /locus_tag="BSU_27785" /old_locus_tag="BSU27785" /label="yrzF gene" S_feature complement(2464756..2465089) /Source="Nicolas_S_feature" /locus_tag="new_2840432_2840765_c" /HighExp="LPhT, S8, BI, S7, S6, C30, Sw, BC, Gly, C90" /AntisenseName="yrzF" /AntisenseCor="0.348831504804749" /AntisenseRegPval="-8.4" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1051" downshifts 2465060 /Source="Nicolas_upshifts" /id="D1421" /incds=0 /nref=29 /ntot=228 /MaxReadThrough="2.4121" /MaxDrop="5.05737" /score="20.8102477" /energy="-18.2" /TU="NA" /idTUdmin="U2147" /TUdmin="-20" /isTUend="TRUE" /label="downshifts" S_feature complement(2465091..2465288) /Source="Nicolas_S_feature" /locus_tag="new_2840767_2840964_c" /HighExp="LPhT, BI, B60, S8, Gly, S7, S6, B36, S5, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99984200000000001" /TUshortSig="Sig-" /TUshortPSig="0.032" /TUlongSig="NA" /TUlongPSig="NA" /label="S1052" CDS complement(2465127..2465249) /locus_tag="BSU_27786" /old_locus_tag="BSU27786" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513992.1" /db_xref="EnsemblGenomes-Gn:BSU27786" /db_xref="EnsemblGenomes-Tr:CCQ48603" /db_xref="UniProtKB/TrEMBL:L8EAY3" /translation="MEKTYCHSGEKDPEAVYLTVRGYRIKLSPEQMKLISAVRK*" /label="hypothetical protein CDS" gene complement(2465127..2465249) /locus_tag="BSU_27786" /old_locus_tag="BSU27786" /label="gene" downshifts complement(2465134) /Source="Nicolas_upshifts" /id="D1422" /incds=0 /nref=3 /ntot=19 /MaxReadThrough="4.39913" /MaxDrop="4.52186" /score="39.5790138" /energy="-18.2" /TU="NA" /idTUdmin="U2149" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(2465297) /Source="Nicolas_upshifts" /id="U2149" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.031968031968032" /xcortree=11 /SigmaFactorBS="cattttactatatatcggattcatataaTCTTTACAtttctt TAAAATTACCTCAATAAAgcaatgataagatgaaataaagccaataaagggtgagggg a" /listShort="S1052" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2465298..2465315) /Source="Nicolas_upshift_promotors" /id="U2149" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.031968031968032" /xcortree=11 /SigmaFactorBS="cattttactatatatcggattcatataaTCTTTACAtttctt TAAAATTACCTCAATAAAgcaatgataagatgaaataaagccaataaagggtgagggg a" /listShort="S1052" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2465322..2465329) /Source="Nicolas_upshift_promotors" /id="U2149" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.031968031968032" /xcortree=11 /SigmaFactorBS="cattttactatatatcggattcatataaTCTTTACAtttctt TAAAATTACCTCAATAAAgcaatgataagatgaaataaagccaataaagggtgagggg a" /listShort="S1052" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2465334..2465624 /gene="yrzH" /locus_tag="BSU_27800" /old_locus_tag="BSU27800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_390658.2" /db_xref="EnsemblGenomes-Gn:BSU27800" /db_xref="EnsemblGenomes-Tr:CAB14740" /db_xref="SubtiList:BG13818" /db_xref="UniProtKB/Swiss-Prot:O32059" /translation="MNPIYSKMREKKGESHIKTENTLSLDAARGELVNEKTLVKRTIY WNYPDSRPAVTWINHNTVKIGNQTLHLDTDETYDWRKDDHWIREEPPQASVR*" /label="yrzH CDS" gene 2465334..2465624 /gene="yrzH" /locus_tag="BSU_27800" /old_locus_tag="BSU27800" /label="yrzH gene" misc_feature 2465345..2465364 /Source="Nicolas_upshift_promotors" /id="U2150" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.462537462537463" /psig="0.903096903096903" /xcortree=657 /SigmaFactorBS="atcttatcattgctttattgaggtaattttaaagaaatgtaa agattatatgaatccgatATATAGTAAAATGAGAGAAAaaaagggagagagtcacatt a" /listShort="S1053, yrzH, yrzT" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 2465345..2465492 /Source="Nicolas_S_feature" /locus_tag="new_2841021_2841168" /HighExp="T3.30H, T4.0H, T3.0H, T2.0H, T2.30H, T5.0H, M9-stat, S7, T1.30H, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99999400000000005" /TUshortSig="SigA" /TUshortPSig="0.903" /TUlongSig="NA" /TUlongPSig="NA" /label="S1053" upshifts 2465345 /Source="Nicolas_upshifts" /id="U2150" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.462537462537463" /psig="0.903096903096903" /xcortree=657 /SigmaFactorBS="atcttatcattgctttattgaggtaattttaaagaaatgtaa agattatatgaatccgatATATAGTAAAATGAGAGAAAaaaagggagagagtcacatt a" /listShort="S1053, yrzH, yrzT" /GFF_Attribute="listLong" /label="upshifts" CDS 2465631..2465771 /gene="yrzT" /locus_tag="BSU_27809" /old_locus_tag="BSU27809" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097769.1" /db_xref="EnsemblGenomes-Gn:BSU27809" /db_xref="EnsemblGenomes-Tr:CAX52675" /db_xref="GOA:C0H464" /db_xref="UniProtKB/Swiss-Prot:C0H464" /translation="MNKMNGTNDEKHFNHFVIALSFIYGLTELGYLLLKDFITIAISL PL*" /label="yrzT CDS" gene 2465631..2465771 /gene="yrzT" /locus_tag="BSU_27809" /old_locus_tag="BSU27809" /label="yrzT gene" downshifts 2465760 /Source="Nicolas_upshifts" /id="D1423" /incds=0 /nref=139 /ntot=241 /MaxReadThrough="0.64189" /MaxDrop="4.74983" /score="23.2933855" /energy="-9.9" /TU="NA" /idTUdmin="U2150" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 2465820..2465826 /Source="Nicolas_upshift_promotors" /id="U2151" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1083 /SigmaFactorBS="cgtagtcgatacgccgcgttttttctttttcccttcctCTTC TTAttgataattacaggTCATATAATGTGACAAATCgattgtagaaatagttcgatta g" /listShort="yrbD, S1054" /GFF_Attribute="listLong" /label="promotor_-35" promotor_no_box 2465834..2465934 /Source="Nicolas_upshift_promotors" /id="U2152" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.383616383616384" /psig="0.376623376623377" /xcortree=317 /SigmaFactorBS="ttacaggtcatataatgtgacaaatcgattgtagaaatagtt cgattagaccaaaatcctttttatacatgtattcgaatttgaagtgagggggaagctt g" /listShort="yrbD" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-10 2465841..2465859 /Source="Nicolas_upshift_promotors" /id="U2151" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1083 /SigmaFactorBS="cgtagtcgatacgccgcgttttttctttttcccttcctCTTC TTAttgataattacaggTCATATAATGTGACAAATCgattgtagaaatagttcgatta g" /listShort="yrbD, S1054" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2465842 /Source="Nicolas_upshifts" /id="U2151" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1083 /SigmaFactorBS="cgtagtcgatacgccgcgttttttctttttcccttcctCTTC TTAttgataattacaggTCATATAATGTGACAAATCgattgtagaaatagttcgatta g" /listShort="yrbD, S1054" /GFF_Attribute="listLong" /label="upshifts" upshifts 2465894 /Source="Nicolas_upshifts" /id="U2152" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.383616383616384" /psig="0.376623376623377" /xcortree=317 /SigmaFactorBS="ttacaggtcatataatgtgacaaatcgattgtagaaatagtt cgattagaccaaaatcctttttatacatgtattcgaatttgaagtgagggggaagctt g" /listShort="yrbD" /GFF_Attribute="listLong" /label="upshifts" CDS 2465935..2467389 /gene="alaP" /locus_tag="BSU_27810" /old_locus_tag="BSU27810" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1400476, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sodium/proton-dependent alanine transporter" /protein_id="NP_390659.2" /db_xref="EnsemblGenomes-Gn:BSU27810" /db_xref="EnsemblGenomes-Tr:CAB14741" /db_xref="GOA:O32060" /db_xref="InterPro:IPR001463" /db_xref="SubtiList:BG13784" /db_xref="UniProtKB/Swiss-Prot:O32060" /translation="MADFVASLNAVLWSTPVIYILLGIGFAFSIMTRFLQVRHLKEMI VQMFKGKSSEAGVSSFQALSIALSGRVGTGNIAGVATAIAFGGPGAVFWMWAIAFIGA ASAFVESTLAQIYKVKQDGQYRGGPAYYIEKGLGIKWFAVLFAAAALIAMAFLMPGVQ SNSIAAGIQNAFGISPFVTGCGLVLLLGFIIFGGVKRIANAAQMIVPFMAIGYILLSL IIIVMNVSELPAVISLIFKSAFALDSAFGGLIGMAISWGVKRGIYSNEAGQGTGPHPA AAAEVSHPVKQGLVQAFSVYIDTLFVCSATAFMILFTGMYNTQAADGSFIVHQLKGVE AGPGFTQAAIDSVLPGFGAGFVAIALFFFAFTTIMAYYYIAETNIAYLARGRESKWAM LGLKLIILAATFYGTVKTASLAWALGDAGLGIMVWLNVIAIVLLAKPALLALKDYERQ KKQGLDPIFDPKALGIKNADFWEKEYTHESERVS*" /label="alaP CDS" gene 2465935..2467389 /gene="alaP" /locus_tag="BSU_27810" /old_locus_tag="BSU27810" /label="alaP gene" downshifts 2467390 /Source="Nicolas_upshifts" /id="D1424" /incds=0 /nref=6 /ntot=43 /MaxReadThrough="5.01314" /MaxDrop="4.4617" /score="6.86850608" /energy="-10.8" /TU="U2151" /idTUdmin="U2152" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2467430..2468152) /gene="yrbC" /locus_tag="BSU_27820" /old_locus_tag="BSU27820" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12060744, 18641136, 20647113; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative factor regulating gene expression" /protein_id="NP_390660.1" /db_xref="EnsemblGenomes-Gn:BSU27820" /db_xref="EnsemblGenomes-Tr:CAB14742" /db_xref="GOA:P94447" /db_xref="InterPro:IPR002876" /db_xref="InterPro:IPR017856" /db_xref="InterPro:IPR026564" /db_xref="InterPro:IPR029072" /db_xref="SubtiList:BG13783" /db_xref="UniProtKB/Swiss-Prot:P94447" /translation="MAGHSKWKNIQKRKNAQDAKRGKIFMKLAKEIYVAAKEGGADPE ANSALRLVIEKAKGANMPNENIDRAIKKAAGGQDGSSYEEITYEGYGPSGIAVMVECV TDNKNRTASNVRTAFNKNGGSLGESGCVAFLFERKGFITIDRTERQIEEDELMLDVLE AGGEELRIEEDLYEVFTEPEHFEEVKTALESKYLISSAEVTMLPNTYAEADDQAVEKL ETLIDVLEDDDDVQEVYTNYRS*" /label="yrbC CDS" gene complement(2467430..2468152) /gene="yrbC" /locus_tag="BSU_27820" /old_locus_tag="BSU27820" /label="yrbC gene" S_feature 2467435..2467856 /Source="Nicolas_S_feature" /locus_tag="new_2843111_2843532" /HighExp="S8, S6, S7, BT, C30, S5, S4, LoTm, C90, S3" /AntisenseName="yrbC" /AntisenseCor="-8.4330852334841305E-2" /AntisenseRegPval="-0.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S1054" downshifts complement(2467446) /Source="Nicolas_upshifts" /id="D1425" /incds=0 /nref=11 /ntot=164 /MaxReadThrough="3.2014" /MaxDrop="3.66865" /score="23.9031001" /energy="-16" /TU="U2153" /idTUdmin="U2153" /TUdmin="-574" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2468175..2468194) /Source="Nicolas_upshift_promotors" /id="U2153" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=1965 /SigmaFactorBS="aggaagggctgccggaagtgatattcggcagccttttTCTTT GCAtcagcgaacatttCCCATTAAAGTGTACATAGAaaatgtaaaagaaggtgaaaac a" /listShort="yrbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2468192) /Source="Nicolas_upshifts" /id="U2153" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=1965 /SigmaFactorBS="aggaagggctgccggaagtgatattcggcagccttttTCTTT GCAtcagcgaacatttCCCATTAAAGTGTACATAGAaaatgtaaaagaaggtgaaaac a" /listShort="yrbC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2468208..2468215) /Source="Nicolas_upshift_promotors" /id="U2153" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=1965 /SigmaFactorBS="aggaagggctgccggaagtgatattcggcagccttttTCTTT GCAtcagcgaacatttCCCATTAAAGTGTACATAGAaaatgtaaaagaaggtgaaaac a" /listShort="yrbC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2468255..2468851) /gene="sgpA" /locus_tag="BSU_27830" /old_locus_tag="BSU27830" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9770294, 10438771, 12562816, 17322312" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9770294, 10438771, 12562816, 17322312; Product type f: factor" /codon_start=1 /transl_table=11 /product="spore germination protein" /protein_id="NP_390661.2" /db_xref="EnsemblGenomes-Gn:BSU27830" /db_xref="EnsemblGenomes-Tr:CAB14743" /db_xref="GOA:P94446" /db_xref="InterPro:IPR019076" /db_xref="SubtiList:BG13782" /db_xref="UniProtKB/Swiss-Prot:P94446" /translation="MGKKMTIASLILMTAGLTACGANDNAMNDTRNNGNTRPIGYYTN ENDADRQGDGIDHDGPVSELMEDQNDGNRNTTNVNNRDRVTADDRVPLATDGTYNNTN NRNMNRNAANNGYDNQENRRLAAKIANRVKQVKNVNDTQVMVSDDRVVIAVKSHREFT KSDRDNVVKAARNYANGRDVQVSTDKGLFRKLHKMNNR*" /label="sgpA CDS" gene complement(2468255..2468851) /gene="sgpA" /locus_tag="BSU_27830" /old_locus_tag="BSU27830" /label="sgpA gene" downshifts complement(2468270) /Source="Nicolas_upshifts" /id="D1426" /incds=0 /nref=96 /ntot=172 /MaxReadThrough="2.47709" /MaxDrop="7.18444" /score="23.9031001" /energy="-16" /TU="NA" /idTUdmin="U2154" /TUdmin="-12" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2468894..2468905) /Source="Nicolas_upshift_promotors" /id="U2154" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=845 /SigmaFactorBS="cagatcactgccaaatggagagaactgacaCGCTTAAcatgc cccccatacGCACATGATAAAagcgagcaaacatgctcaattcgtccacggggggttt t" /listShort="coxA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2468896) /Source="Nicolas_upshifts" /id="U2154" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=845 /SigmaFactorBS="cagatcactgccaaatggagagaactgacaCGCTTAAcatgc cccccatacGCACATGATAAAagcgagcaaacatgctcaattcgtccacggggggttt t" /listShort="coxA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2468898..2468962) /Source="Nicolas_S_feature" /locus_tag="new_2844574_2844638_c" /HighExp="B36, LoTm, S8, S6, S5, BT, B60, S4, S7, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigEF, SigA" /TUshortPSig="1, 0.999, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1055" promotor_-35 complement(2468920..2468926) /Source="Nicolas_upshift_promotors" /id="U2154" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=845 /SigmaFactorBS="cagatcactgccaaatggagagaactgacaCGCTTAAcatgc cccccatacGCACATGATAAAagcgagcaaacatgctcaattcgtccacggggggttt t" /listShort="coxA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2468999..2470162) /gene="safA" /locus_tag="BSU_27840" /old_locus_tag="BSU27840" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10438771, 10714986, 10714992, 11040425, 15901704, 26953338" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10438771, 10714986, 10714992, 11040425, 15901704, 26953338; Product type f : factor" /codon_start=1 /transl_table=11 /product="morphogenetic protein associated with SpoVID" /protein_id="NP_390662.1" /db_xref="EnsemblGenomes-Gn:BSU27840" /db_xref="EnsemblGenomes-Tr:CAB14744" /db_xref="GOA:O32062" /db_xref="InterPro:IPR014248" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG13781" /db_xref="UniProtKB/Swiss-Prot:O32062" /translation="MKIHIVQKGDSLWKIAEKYGVDVEEVKKLNTQLSNPDLIMPGMK IKVPSEGVPVRKEPKAGKSPAAGSVKQEHPYAKEKPKSVVDVEDTKPKEKKSMPYVPP MPNLQENVYPEADVNDYYDMKQLFQPWSPPKPEEPKKHHDGNMDHMYHMQDQFPQQEA MSNMENANYPNMPNMPKAPEVGGIEEENVHHTVPNMPMPAVQPYYHYPAHFVPCPVPV SPILPGSGLCYPYYPAQAYPMHPMHGYQPGFVSPQYDPGYENQHHENSHHGHYGSYGA PQYASPAYGSPYGHMPYGPYYGTPQVMGAYQPAAAHGYMPYKDHDDCGCDGDHQPYFS APGHSGMGAYGSPNMPYGTANPNPNPYSAGVSMPMTNQPSVNQMFGRPEEENE*" /label="safA CDS" gene complement(2468999..2470162) /gene="safA" /locus_tag="BSU_27840" /old_locus_tag="BSU27840" /label="safA gene" downshifts complement(2469007) /Source="Nicolas_upshifts" /id="D1427" /incds=0 /nref=34 /ntot=189 /MaxReadThrough="5.61903" /MaxDrop="3.9565" /score="38.1347732" /energy="-11.1" /TU="U2155,U2156,U2159" /idTUdmin="U2154" /TUdmin="-749" /isTUend="FALSE" /label="downshifts" S_feature complement(2470163..2470238) /Source="Nicolas_S_feature" /locus_tag="new_2845839_2845914_c" /HighExp="S5, S4, B36, LoTm, S3, B60, S7, S6, Pyr, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigEF, SigA" /TUshortPSig="1, 0.999, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1056" promotor_-10 complement(2470214..2470232) /Source="Nicolas_upshift_promotors" /id="U2155" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1106 /SigmaFactorBS="gaatgctttcgatcacgtagatcagaaatattttcccttcct ttaCTCATAacttcttttgttcagGCATATGTTGTGAAGAAACatattgtaatcacag c" /listShort="S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2470238) /Source="Nicolas_upshifts" /id="U2155" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1106 /SigmaFactorBS="gaatgctttcgatcacgtagatcagaaatattttcccttcct ttaCTCATAacttcttttgttcagGCATATGTTGTGAAGAAACatattgtaatcacag c" /listShort="S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2470248..2470253) /Source="Nicolas_upshift_promotors" /id="U2155" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1106 /SigmaFactorBS="gaatgctttcgatcacgtagatcagaaatattttcccttcct ttaCTCATAacttcttttgttcagGCATATGTTGTGAAGAAACatattgtaatcacag c" /listShort="S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2470279..2471385) /gene="nadA" /locus_tag="BSU_27850" /old_locus_tag="BSU27850" /EC_number="2.5.1.72" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:15898769, 15937336, 15967443, 18959769, 26455817" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15898769, 15937336, 15967443, 18959769, 26455817; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="quinolinate synthetase" /protein_id="NP_390663.1" /db_xref="EnsemblGenomes-Gn:BSU27850" /db_xref="EnsemblGenomes-Tr:CAB14745" /db_xref="GOA:Q9KWZ1" /db_xref="InterPro:IPR003473" /db_xref="InterPro:IPR023515" /db_xref="InterPro:IPR036094" /db_xref="SubtiList:BG12629" /db_xref="UniProtKB/Swiss-Prot:Q9KWZ1" /translation="MSILDVIKQSNDMMPESYKELSRKDMETRVAAIKKKFGSRLFIP GHHYQKDEVIQFADQTGDSLQLAQVAEKNKEADYIVFCGVHFMAETADMLTSEQQTVV LPDMRAGCSMADMADMQQTNRAWKKLQHIFGDTIIPLTYVNSTAEIKAFVGKHGGATV TSSNAKKVLEWAFTQKKRILFLPDQHLGRNTAYDLGIALEDMAVWDPMKDELVAESGH TNVKVILWKGHCSVHEKFTTKNIHDMRERDPDIQIIVHPECSHEVVTLSDDNGSTKYI IDTINQAPAGSKWAIGTEMNLVQRIIHEHPDKQIESLNPDMCPCLTMNRIDLPHLLWS LEQIEKGEPSGVIKVPKAIQEDALLALNRMLSIT*" /label="nadA CDS" gene complement(2470279..2471385) /gene="nadA" /locus_tag="BSU_27850" /old_locus_tag="BSU27850" /label="nadA gene" promotor_-10 complement(2470961..2470979) /Source="Nicolas_upshift_promotors" /id="U2156" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1174 /SigmaFactorBS="gacatggctgacatgcagcagaccaatagggcatggaagaag cttcAGCATAtatttggagatacgaTCATACCTTTAACTTATGTgaactccactgcgg a" /listShort="S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2470986) /Source="Nicolas_upshifts" /id="U2156" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1174 /SigmaFactorBS="gacatggctgacatgcagcagaccaatagggcatggaagaag cttcAGCATAtatttggagatacgaTCATACCTTTAACTTATGTgaactccactgcgg a" /listShort="S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2470995..2471000) /Source="Nicolas_upshift_promotors" /id="U2156" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1174 /SigmaFactorBS="gacatggctgacatgcagcagaccaatagggcatggaagaag cttcAGCATAtatttggagatacgaTCATACCTTTAACTTATGTgaactccactgcgg a" /listShort="S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2471297 /Source="Nicolas_upshifts" /id="U2157" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.993006993006993" /psig=0 /xcortree=25 /SigmaFactorBS="ttttgataatgatggcctggtataaagagcctgctgccgaac tttttcttaatggcggcaaCGCGcgtttccatatcctttctcgatagttctttataac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 2471298..2471301 /Source="Nicolas_upshift_promotors" /id="U2157" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.993006993006993" /psig=0 /xcortree=25 /SigmaFactorBS="ttttgataatgatggcctggtataaagagcctgctgccgaac tttttcttaatggcggcaaCGCGcgtttccatatcctttctcgatagttctttataac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(2471372..2472241) /gene="nadC" /locus_tag="BSU_27860" /old_locus_tag="BSU27860" /EC_number="2.4.2.19" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8419294, 28618168; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nicotinate-nucleotide pyrophosphorylase (quinolinate phosphoribosyltransferase)" /protein_id="NP_390664.1" /db_xref="EnsemblGenomes-Gn:BSU27860" /db_xref="EnsemblGenomes-Tr:CAB14746" /db_xref="GOA:P39666" /db_xref="InterPro:IPR002638" /db_xref="InterPro:IPR004393" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR022412" /db_xref="InterPro:IPR027277" /db_xref="InterPro:IPR036068" /db_xref="InterPro:IPR037128" /db_xref="SubtiList:BG10868" /db_xref="UniProtKB/Swiss-Prot:P39666" /translation="MNHLQLKKLLNHFFLEDIGTGDLTSQSIFGEQSCEAEIVAKSEG IFAGAAIIKEGFSLLDENVQSILHKKDGDMLHKGEVIAELHGPAAALLSGERVVLNLI QRLSGIATMTREAVRCLDDEQIKICDTRKTTPGLRMLEKYAVRAGGGYNHRFGLYDGI MIKDNHIAACGSILEACKKARQAAGHMVNIEVEIETEEQLREAIAAGADVIMFDNCPP DTVRHFAKLTPANIKTEASGGITLESLPAFKGTGVNYISLGFLTHSVKSLDISMDVTL SNESVEECCYVNS*" /label="nadC CDS" gene complement(2471372..2472241) /gene="nadC" /locus_tag="BSU_27860" /old_locus_tag="BSU27860" /label="nadC gene" downshifts 2471466 /Source="Nicolas_upshifts" /id="D1428" /incds=1 /nref=4 /ntot=107 /MaxReadThrough="0.495279999999999" /MaxDrop="3.83418" /score="-8.75482157" /energy="-7.4" /TU="NA" /idTUdmin="U2157" /TUdmin=6 /isTUend="TRUE" /label="downshifts" CDS complement(2472195..2473790) /gene="nadB" /locus_tag="BSU_27870" /old_locus_tag="BSU27870" /EC_number="1.4.3.16" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8444804, 16199587, 18959769" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8444804, 16199587, 18959769; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-aspartate oxidase" /protein_id="NP_390665.1" /db_xref="EnsemblGenomes-Gn:BSU27870" /db_xref="EnsemblGenomes-Tr:CAB14747" /db_xref="GOA:P38032" /db_xref="InterPro:IPR003953" /db_xref="InterPro:IPR005288" /db_xref="InterPro:IPR015939" /db_xref="InterPro:IPR027477" /db_xref="InterPro:IPR036188" /db_xref="InterPro:IPR037099" /db_xref="SubtiList:BG10867" /db_xref="UniProtKB/Swiss-Prot:P38032" /translation="MSKKTIAVIGSGAAALSLAAAFPPSYEVTVITKKSVKNSNSVYA QGGIAAAYAKDDSIEAHLEDTLYAGCGHNNLAIVADVLHDGKMMVQSLLERGFPFDRN ERGGVCLGREGAHSYNRIFHAGGDATGRLLIDYLLKRINSKIKLIENETAADLLIEDG RCIGVMTKDSKGRLKVRHADEVVLAAGGCGNLFLHHTNDLTVTGDGLSLAYRAGAELT DLEFTQFHPTLLVKNGVSYGLVSEAVRGEGGCLVDENGRRIMAERHPLGDLAPRDIVS RVIHEEMAKGNRVYIDFSAISDFETRFPTITAICEKAGIDIHSGKIPVAPGMHFLMGG VSVNRWGETTVPGLYAIGETACSGLHGANRLASNSLLEALVFGKRAAEHIIQKPVYNR QYQSGLETSVFYEVPDIEGHELQSKMTSHMSILREQSSLIELSIWLHTLPFQEVNVKD ITIRQMELSHLWQTAKLMTFSALLREESRGAHFRTDFPHAEVSWQGRQIVHTKKGTKI RKNEGIWNNESFTAEKITESLFS*" /label="nadB CDS" gene complement(2472195..2473790) /gene="nadB" /locus_tag="BSU_27870" /old_locus_tag="BSU27870" /label="nadB gene" promotor_-35 2473818..2473825 /Source="Nicolas_upshift_promotors" /id="U2158" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2916 /SigmaFactorBS="ctttttagacatatgccatcctcctgttgtttacacctgTCT TGACAcctatatttacacaaGGATAAAATAAACTCAAGAGttttttatggagaacgga t" /listShort="nifS, nadR, S1057" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2473818..2473837) /Source="Nicolas_upshift_promotors" /id="U2159" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.97002997002997" /psig="0.996003996003996" /xcortree=2917 /SigmaFactorBS="aataaatcatccggtcttcctccatccgttctccataaaaaa cTCTTGAGTttattttatccttgTGTAAATATAGGTGTCAAGAcaggtgtaaacaaca g" /listShort="nadB, nadC, nadA, S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2473839 /Source="Nicolas_upshifts" /id="U2158" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2916 /SigmaFactorBS="ctttttagacatatgccatcctcctgttgtttacacctgTCT TGACAcctatatttacacaaGGATAAAATAAACTCAAGAGttttttatggagaacgga t" /listShort="nifS, nadR, S1057" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2473841..2473860 /Source="Nicolas_upshift_promotors" /id="U2158" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2916 /SigmaFactorBS="ctttttagacatatgccatcctcctgttgtttacacctgTCT TGACAcctatatttacacaaGGATAAAATAAACTCAAGAGttttttatggagaacgga t" /listShort="nifS, nadR, S1057" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2473842) /Source="Nicolas_upshifts" /id="U2159" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.97002997002997" /psig="0.996003996003996" /xcortree=2917 /SigmaFactorBS="aataaatcatccggtcttcctccatccgttctccataaaaaa cTCTTGAGTttattttatccttgTGTAAATATAGGTGTCAAGAcaggtgtaaacaaca g" /listShort="nadB, nadC, nadA, S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2473852..2473859) /Source="Nicolas_upshift_promotors" /id="U2159" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.97002997002997" /psig="0.996003996003996" /xcortree=2917 /SigmaFactorBS="aataaatcatccggtcttcctccatccgttctccataaaaaa cTCTTGAGTttattttatccttgTGTAAATATAGGTGTCAAGAcaggtgtaaacaaca g" /listShort="nadB, nadC, nadA, S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2473893..2475080 /gene="nifS" /locus_tag="BSU_27880" /old_locus_tag="BSU27880" /EC_number="2.8.1.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8444804, 14567704, 16199587, 25447671, 26443755, 28882201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8444804, 14567704, 16199587, 25447671, 26443755, 28882201; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="desulfurase involved in iron-sulfur clusters forNAD biosynthesis" /protein_id="NP_390666.1" /db_xref="EnsemblGenomes-Gn:BSU27880" /db_xref="EnsemblGenomes-Tr:CAB14748" /db_xref="GOA:P38033" /db_xref="InterPro:IPR000192" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR016454" /db_xref="InterPro:IPR020578" /db_xref="SubtiList:BG10866" /db_xref="UniProtKB/Swiss-Prot:P38033" /translation="MIYLDYAATTPICEEALTVYQKLSMDMYGNASSLHDAGGKAKHI LEYCREKIANIIGGEASGIYFTSGGTESNFLAIQSLLNGLPKTKRHFITTAMEHQSIH NCAAFLEQQGYDVTVIEPNEYGLITEEILLTHIRPETGLVSIQHANSETGIIQPIQHL SSYLHNKGILLHCDAVQTFGKIPINTKNLGVDALSMSSHKIHGPKGVGAVYIRPDVPW KPVYPLTTHEYGFRAGTVNVPGIGAFTAAAELIVSEMEKQISRNEALRTYFLDQIRIR SLPVTLAADTSKAECLPHIIGCFFHSFEGQYVMLECNRSNICISTGSACSAGYHGPSE TMKALRKTEQEALQFIRISFGRHTTAEQLEQLLHTFTVLWEQKKGEFDIDRRIKANGR QQA*" /label="nifS CDS" gene 2473893..2475080 /gene="nifS" /locus_tag="BSU_27880" /old_locus_tag="BSU27880" /label="nifS gene" promotor_-10 complement(2473894..2473913) /Source="Nicolas_upshift_promotors" /id="U2160" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1362 /SigmaFactorBS="atatccatactaagcttctgatatacagtaagggcTTCCTCA CAAataggcgttgtcgcTGCATAATCTAAATAAATCAtccggtcttcctccatccgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2473912) /Source="Nicolas_upshifts" /id="U2160" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1362 /SigmaFactorBS="atatccatactaagcttctgatatacagtaagggcTTCCTCA CAAataggcgttgtcgcTGCATAATCTAAATAAATCAtccggtcttcctccatccgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2473928..2473937) /Source="Nicolas_upshift_promotors" /id="U2160" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1362 /SigmaFactorBS="atatccatactaagcttctgatatacagtaagggcTTCCTCA CAAataggcgttgtcgcTGCATAATCTAAATAAATCAtccggtcttcctccatccgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2474795..2474800 /Source="Nicolas_upshift_promotors" /id="U2161" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.79020979020979" /psig=1 /xcortree=1922 /SigmaFactorBS="cttcgaaagcagaatgtcttccgcatattatagggtgttttt ttcaCTCATTtgaaggacaaTATGTTATGTTAGAATGTAAtcggagtaatatttgcat t" /listShort="nadR" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2474809 /Source="Nicolas_upshifts" /id="U2161" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.79020979020979" /psig=1 /xcortree=1922 /SigmaFactorBS="cttcgaaagcagaatgtcttccgcatattatagggtgttttt ttcaCTCATTtgaaggacaaTATGTTATGTTAGAATGTAAtcggagtaatatttgcat t" /listShort="nadR" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2474811..2474830 /Source="Nicolas_upshift_promotors" /id="U2161" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.79020979020979" /psig=1 /xcortree=1922 /SigmaFactorBS="cttcgaaagcagaatgtcttccgcatattatagggtgttttt ttcaCTCATTtgaaggacaaTATGTTATGTTAGAATGTAAtcggagtaatatttgcat t" /listShort="nadR" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2475040..2475582 /gene="niaR" /locus_tag="BSU_27890" /old_locus_tag="BSU27890" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16199587, 18276644" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16199587, 18276644; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of de novo NAD biosynthesis" /protein_id="NP_390667.2" /db_xref="EnsemblGenomes-Gn:BSU27890" /db_xref="EnsemblGenomes-Tr:CAB14749" /db_xref="GOA:P39667" /db_xref="InterPro:IPR004173" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR026043" /db_xref="InterPro:IPR035922" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10865" /db_xref="UniProtKB/Swiss-Prot:P39667" /translation="MTEELKLMGANRRDQLLLWLKESKSPLTGGELAKKANVSRQVIV QDISLLKAKNVPIIATSQGYVYMDAAAQQHQQAERIIACLHGPERTEEELQLIVDEGV TVKDVKIEHPVYGDLTAAIQVGTRKEVSHFIKKINSTNAAYLSQLTDGVHLHTLTAPD EHRIDQACQALEEAGILIKD*" /label="niaR CDS" gene 2475040..2475582 /gene="niaR" /locus_tag="BSU_27890" /old_locus_tag="BSU27890" /label="niaR gene" downshifts 2475565 /Source="Nicolas_upshifts" /id="D1429" /incds=0 /nref=109 /ntot=246 /MaxReadThrough="3.55509" /MaxDrop="5.04771" /score="15.054047" /energy="-5.6" /TU="U2158" /idTUdmin="U2161" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" CDS complement(2475607..2476464) /gene="pheA" /locus_tag="BSU_27900" /old_locus_tag="BSU27900" /EC_number="4.2.1.51" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:104661, 114523" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 104661, 114523; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="prephenate dehydratase" /protein_id="NP_390668.1" /db_xref="EnsemblGenomes-Gn:BSU27900" /db_xref="EnsemblGenomes-Tr:CAB14750" /db_xref="GOA:P21203" /db_xref="InterPro:IPR001086" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR008242" /db_xref="InterPro:IPR018528" /db_xref="SubtiList:BG10914" /db_xref="UniProtKB/Swiss-Prot:P21203" /translation="MKVGYLGPAATFTHLAVSSCFQNGAEHVAYRTIPECIDAAVAGE VDFAFVPLENALEGSVNLTIDYLIHEQPLPIVGEMTLPIHQHLLVHPSRENAWKELDK IYSHSHAIAQCHKFLHRHFPSVPYEYANSTGAAAKFVSDHPELNIGVIANDMAASTYE LKIVKRDIQDYRDNHTRFVILSPDENISFEVNSKLSSRPKTTLMVMLPQDDQSGALHR VLSAFSWRNLNLSKIESRPTKTGLGHYFFIIDIEKAFDDVLIPGAMQELEALGCKVRL LGAYQSYQL*" /label="pheA CDS" gene complement(2475607..2476464) /gene="pheA" /locus_tag="BSU_27900" /old_locus_tag="BSU27900" /label="pheA gene" S_feature 2475610..2476319 /Source="Nicolas_S_feature" /locus_tag="new_2851286_2851995" /HighExp="S2, T-5.40H, T3.30H, T-4.40H, GM-0.2, GM-0.1, Pyr, T4.0H, T5.0H, GM 10" /AntisenseName="pheA" /AntisenseCor="-0.15664933741609299" /AntisenseRegPval="-2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1057" downshifts complement(2475627) /Source="Nicolas_upshifts" /id="D1430" /incds=0 /nref=173 /ntot=247 /MaxReadThrough="1.87872" /MaxDrop="5.15605" /score="13.965695" /energy="-5.6" /TU="NA" /idTUdmin="U2162" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2476481..2476924) /gene="thrR" /locus_tag="BSU_27910" /old_locus_tag="BSU27910" /experiment="publication(s) with functional evidences, PMID:2537815, 27260660" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2537815, 27260660; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of operons hom-thrCB and thrD" /protein_id="NP_390669.1" /db_xref="EnsemblGenomes-Gn:BSU27910" /db_xref="EnsemblGenomes-Tr:CAB14751" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR008310" /db_xref="SubtiList:BG10913" /db_xref="UniProtKB/Swiss-Prot:P21204" /translation="MKEETFYLVREDVLPDAMRKTLEVKKLLDRKKADSVADAVQKVD LSRSAFYKYRDAVFPFYTMVKEQIITLFFHLEDRSGALSQLLQAVADSGSNVLSIHQT IPLQGRANVTLSISTSAMEEDIHTLMNKLRKFDFVEKVEILGSGA*" /label="thrR CDS" gene complement(2476481..2476924) /gene="thrR" /locus_tag="BSU_27910" /old_locus_tag="BSU27910" /label="thrR gene" CDS complement(2476985..2478271) /gene="obgE" /locus_tag="BSU_27920" /old_locus_tag="BSU27920" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10781545, 12682299, 15325267, 15827604, 18689482, 20830302, 24844575, 26951678, 28357361" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10781545, 12682299, 15325267, 15827604, 18689482, 20830302, 24844575, 26951678, 28357361; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ppGpp-binding GTPase involved in cell portioning, DNA repair and ribosome assembly" /protein_id="NP_390670.1" /db_xref="EnsemblGenomes-Gn:BSU27920" /db_xref="EnsemblGenomes-Tr:CAB14752" /db_xref="GOA:P20964" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR006074" /db_xref="InterPro:IPR006169" /db_xref="InterPro:IPR014100" /db_xref="InterPro:IPR015349" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031167" /db_xref="InterPro:IPR035101" /db_xref="InterPro:IPR036346" /db_xref="InterPro:IPR036726" /db_xref="PDB:1LNZ" /db_xref="SubtiList:BG10337" /db_xref="UniProtKB/Swiss-Prot:P20964" /translation="MFVDQVKVYVKGGDGGNGMVAFRREKYVPKGGPAGGDGGKGGDV VFEVDEGLRTLMDFRYKKHFKAIRGEHGMSKNQHGRNADDMVIKVPPGTVVTDDDTKQ VIADLTEHGQRAVIARGGRGGRGNSRFATPANPAPQLSENGEPGKERYIVLELKVLAD VGLVGFPSVGKSTLLSVVSSAKPKIADYHFTTLVPNLGMVETDDGRSFVMADLPGLIE GAHQGVGLGHQFLRHIERTRVIVHVIDMSGLEGRDPYDDYLTINQELSEYNLRLTERP QIIVANKMDMPEAAENLEAFKEKLTDDYPVFPISAVTREGLRELLFEVANQLENTPEF PLYDEEELTQNRVMYTMENEEVPFNITRDPDGVFVLSGDSLERLFKMTDFSRDESVKR FARQMRGMGVDEALRERGAKDGDIIRLLEFEFEFID*" /label="obgE CDS" gene complement(2476985..2478271) /gene="obgE" /locus_tag="BSU_27920" /old_locus_tag="BSU27920" /label="obgE gene" CDS complement(2478305..2478883) /gene="spo0B" /locus_tag="BSU_27930" /old_locus_tag="BSU27930" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9443976, 9477965, 9726997, 9809070, 10997904, 16788205, 27679485" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9443976, 9477965, 9726997, 9809070, 10997904, 16788205, 27679485; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sporulation initiation phosphotransferase" /protein_id="NP_390671.1" /db_xref="EnsemblGenomes-Gn:BSU27930" /db_xref="EnsemblGenomes-Tr:CAB14753" /db_xref="GOA:P06535" /db_xref="InterPro:IPR016120" /db_xref="InterPro:IPR016122" /db_xref="InterPro:IPR037100" /db_xref="PDB:1F51" /db_xref="PDB:1IXM" /db_xref="PDB:2FTK" /db_xref="SubtiList:BG10336" /db_xref="UniProtKB/Swiss-Prot:P06535" /translation="MKDVSKNQEENISDTALTNELIHLLGHSRHDWMNKLQLIKGNLS LQKYDRVFEMIEEMVIDAKHESKLSNLKTPHLAFDFLTFNWKTHYMTLEYEVLGEIKD LSAYDQKLAKLMRKLFHLFDQAVSRESENHLTVSLQTDHPDRQLILYLDFHGAFADPS AFDDIRQNGYEDVDIMRFEITSHECLIEIGLD*" /label="spo0B CDS" gene complement(2478305..2478883) /gene="spo0B" /locus_tag="BSU_27930" /old_locus_tag="BSU27930" /label="spo0B gene" S_feature complement(2478884..2478949) /Source="Nicolas_S_feature" /locus_tag="new_2854560_2854625_c" /HighExp="Cold, H2O2, G135, Paraq, G180, Oxctl, G150, C30, LPh, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 1" /TUlongSig="SigEF" /TUlongPSig=1 /label="S1058" promotor_-10 complement(2478934..2478953) /Source="Nicolas_upshift_promotors" /id="U2162" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.522477522477522" /psig="0.997002997002997" /xcortree=3176 /SigmaFactorBS="gaaaaaaggaacatgatatttctgggaaaaacaatTGTTTTT CtaacaaagccttcTCTGTTATAATTCATAATACacacttatacagactcctaaataa g" /listShort="S1058, spo0B, obg, yszB, pheA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2478949) /Source="Nicolas_upshifts" /id="U2162" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.522477522477522" /psig="0.997002997002997" /xcortree=3176 /SigmaFactorBS="gaaaaaaggaacatgatatttctgggaaaaacaatTGTTTTT CtaacaaagccttcTCTGTTATAATTCATAATACacacttatacagactcctaaataa g" /listShort="S1058, spo0B, obg, yszB, pheA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2478951..2479168) /Source="Nicolas_S_feature" /locus_tag="new_2854627_2854844_c" /HighExp="Cold, G135, H2O2, Paraq, G180, Oxctl, G150, C30, LPh, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig=1 /label="S1059" CDS 2478961..2479083 /locus_tag="BSU_27935" /old_locus_tag="BSU27935" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513993.1" /translation="MLEKQLFFPEISCSFFLALVDLQPGRTFYVLLLGEHIQWV*" /label="hypothetical protein CDS" gene 2478961..2479083 /locus_tag="BSU_27935" /old_locus_tag="BSU27935" /label="gene" promotor_-35 complement(2478967..2478974) /Source="Nicolas_upshift_promotors" /id="U2162" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.522477522477522" /psig="0.997002997002997" /xcortree=3176 /SigmaFactorBS="gaaaaaaggaacatgatatttctgggaaaaacaatTGTTTTT CtaacaaagccttcTCTGTTATAATTCATAATACacacttatacagactcctaaataa g" /listShort="S1058, spo0B, obg, yszB, pheA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2479204..2479488) /gene="rpmA" /locus_tag="BSU_27940" /old_locus_tag="BSU27940" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9000630, 9588797, 11399077, 12682299, 14586115, 17981968, 22720735, 24335279, 25388641, 27435445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9000630, 9588797, 11399077, 12682299, 14586115, 17981968, 22720735, 24335279, 25388641, 27435445; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L27 (BL24)" /protein_id="NP_390672.1" /db_xref="EnsemblGenomes-Gn:BSU27940" /db_xref="EnsemblGenomes-Tr:CAB14754" /db_xref="GOA:P05657" /db_xref="InterPro:IPR001684" /db_xref="InterPro:IPR018261" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10335" /db_xref="UniProtKB/Swiss-Prot:P05657" /translation="MLRLDLQFFASKKGVGSTKNGRDSEAKRLGAKRADGQFVTGGSI LYRQRGTKIYPGENVGRGGDDTLFAKIDGTVKFERFGRDRKKVSVYPVAQ*" /label="rpmA CDS" gene complement(2479204..2479488) /gene="rpmA" /locus_tag="BSU_27940" /old_locus_tag="BSU27940" /label="rpmA gene" downshifts complement(2479213) /Source="Nicolas_upshifts" /id="D1431" /incds=0 /nref=212 /ntot=261 /MaxReadThrough="7.39131" /MaxDrop="7.26483" /score="32.4992871" /energy="-12.5" /TU="U2163" /idTUdmin="U2164" /TUdmin=1078 /isTUend="FALSE" /label="downshifts" CDS complement(2479501..2479839) /gene="rppA" /locus_tag="BSU_27950" /old_locus_tag="BSU27950" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11567142, 22333191, 25388641, 27435445, 28187498; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosomal protein L27 specific N-terminal end cysteine protease" /protein_id="NP_390673.2" /db_xref="EnsemblGenomes-Gn:BSU27950" /db_xref="EnsemblGenomes-Tr:CAB14755" /db_xref="InterPro:IPR007422" /db_xref="InterPro:IPR036764" /db_xref="SubtiList:BG10334" /db_xref="UniProtKB/Swiss-Prot:P26942" /translation="MIQATIRRSHDKGILSFEMTGHANFAEHGQDLVCAGVTAVVFGA VNAVIVLAGFEPLLDIGEDGGYFYFEFPESLDPEARQKAQLLIEGMIVSLETIERDYK DNLRVTTNII*" /label="rppA CDS" gene complement(2479501..2479839) /gene="rppA" /locus_tag="BSU_27950" /old_locus_tag="BSU27950" /label="rppA gene" CDS complement(2479842..2480150) /gene="rplU" /locus_tag="BSU_27960" /old_locus_tag="BSU27960" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8223574, 12682299, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8223574, 12682299, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L21 (BL20)" /protein_id="NP_390674.1" /db_xref="EnsemblGenomes-Gn:BSU27960" /db_xref="EnsemblGenomes-Tr:CAB14756" /db_xref="GOA:P26908" /db_xref="InterPro:IPR001787" /db_xref="InterPro:IPR018258" /db_xref="InterPro:IPR028909" /db_xref="InterPro:IPR036164" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10333" /db_xref="UniProtKB/Swiss-Prot:P26908" /translation="MYAIIKTGGKQIKVEEGQTVYIEKLAAEAGETVTFEDVLFVGGD NVKVGNPTVEGATVTAKVEKQGRAKKITVFRYKPKKNVHKKQGHRQPYTKVTIEKINA *" /label="rplU CDS" gene complement(2479842..2480150) /gene="rplU" /locus_tag="BSU_27960" /old_locus_tag="BSU27960" /label="rplU gene" misc_RNA complement(2480164..2480239) /gene="ldlU" /locus_tag="BSU_misc_RNA_43" /product="ribosomal protein L21 leader mRNA sequence" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 27381917" /label="ldlU RNA" gene complement(2480164..2480239) /gene="ldlU" /locus_tag="BSU_misc_RNA_43" /label="ldlU gene" promotor_-10 complement(2480251..2480270) /Source="Nicolas_upshift_promotors" /id="U2163" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.848151848151848" /psig=1 /xcortree=2655 /SigmaFactorBS="attcttccatggaggaactgcttctgccctactaaaactgAT TGACAAacgccttgtatttTGGTATATTTTTTAATGTTAtggatgtagcaccattgct a" /listShort="NA, rplU, ysxB, rpmA, S1059, S1058, spo0B, obg, yszB, pheA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2480271) /Source="Nicolas_upshifts" /id="U2163" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.848151848151848" /psig=1 /xcortree=2655 /SigmaFactorBS="attcttccatggaggaactgcttctgccctactaaaactgAT TGACAAacgccttgtatttTGGTATATTTTTTAATGTTAtggatgtagcaccattgct a" /listShort="NA, rplU, ysxB, rpmA, S1059, S1058, spo0B, obg, yszB, pheA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2480284..2480291) /Source="Nicolas_upshift_promotors" /id="U2163" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.848151848151848" /psig=1 /xcortree=2655 /SigmaFactorBS="attcttccatggaggaactgcttctgccctactaaaactgAT TGACAAacgccttgtatttTGGTATATTTTTTAATGTTAtggatgtagcaccattgct a" /listShort="NA, rplU, ysxB, rpmA, S1059, S1058, spo0B, obg, yszB, pheA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2480297..2481163) /gene="spoIVFB" /locus_tag="BSU_27970" /old_locus_tag="BSU27970" /EC_number="3.4.24.-" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10809718, 11959848, 15087499, 16731018, 16816000, 16818230, 26953342, 29180425" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10809718, 11959848, 15087499, 16731018, 16816000, 16818230, 26953342, 29180425; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="membrane metalloprotease [proteolysis of pro-sigma(K)]" /protein_id="NP_390675.1" /db_xref="EnsemblGenomes-Gn:BSU27970" /db_xref="EnsemblGenomes-Tr:CAB14757" /db_xref="GOA:P26937" /db_xref="InterPro:IPR008915" /db_xref="SubtiList:BG10332" /db_xref="UniProtKB/Swiss-Prot:P26937" /translation="MNKWLDLILKIHVHPFLWIIAALGLLTGHMKALLCLLLIVLIHE LGHAALAVFFSWRIKRVFLLPFGGTVEVEEHGNRPLKEEFAVIIAGPLQHIWLQFAAW MLAEVSVIHQHTFELFTFYNLSILFVNLLPIWPLDGGKLLFLLFSKQLPFQKAHRLNL KTSLCFCLLLGCWVLFVIPLQISAWVLFVFLAVSLFEEYRQRHYIHVRFLLERYYGKN RELEKLLPLTVKAEDKVYHVMAEFKRGCKHPIIIEKSGQKLSQLDENEVLHAYFADKR TNSSMEELLLPY*" /label="spoIVFB CDS" gene complement(2480297..2481163) /gene="spoIVFB" /locus_tag="BSU_27970" /old_locus_tag="BSU27970" /label="spoIVFB gene" CDS complement(2481156..2481950) /gene="spoIVFA" /locus_tag="BSU_27980" /old_locus_tag="BSU27980" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10809718, 11959848, 15087499, 16731018, 16816000, 16818230, 17824930, 22882546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10809718, 11959848, 15087499, 16731018, 16816000, 16818230, 17824930, 22882546; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of SpoIVFB (stage IV sporulation)" /protein_id="NP_390676.1" /db_xref="EnsemblGenomes-Gn:BSU27980" /db_xref="EnsemblGenomes-Tr:CAB14758" /db_xref="GOA:P26936" /db_xref="InterPro:IPR011055" /db_xref="InterPro:IPR016047" /db_xref="SubtiList:BG10331" /db_xref="UniProtKB/Swiss-Prot:P26936" /translation="MSHRADEIRKRLEKRRKQLSGSKRFSTQTVSEKQKPPSWVMVTD QEKHGTLPVYEDNMPTFNGKHPLVKTDSIILKCLLSACLVLVSAIAYKTNIGPVSQIK PAVAKTFETEFQFASASHWFETKFGNPLAFLAPEHKNKEQQIEVGKDLIAPASGKVQQ DFQDNGEGIKVETSSDKIDSVKEGYVVEVSKDSQTGLTVKVQHADNTYSIYGELKDVD VALYDFVDKGKKLGSIKLDDHNKGVYYFAMKDGDKFIDPIQVISFE*" /label="spoIVFA CDS" gene complement(2481156..2481950) /gene="spoIVFA" /locus_tag="BSU_27980" /old_locus_tag="BSU27980" /label="spoIVFA gene" downshifts 2481953 /Source="Nicolas_upshifts" /id="D1432" /incds=0 /nref=1 /ntot=7 /MaxReadThrough="1.00279" /MaxDrop="2.6024" /score="-6.66807377" /energy="-6.9" /TU="NA" /idTUdmin="U2165" /TUdmin="-131" /isTUend="FALSE" /label="downshifts" promotor_no_box 2481959..2482059 /Source="Nicolas_upshift_promotors" /id="U2165" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.536463536463537" /psig="0.242757242757243" /xcortree=281 /SigmaFactorBS="tcctttgcattcgttgggtttgtacatcatatgtcttgtcca tggcaaatattcggtttagtcaagaacaaagcaggcaaaaacaaaaaaaacctgacac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-10 complement(2481974..2481992) /Source="Nicolas_upshift_promotors" /id="U2164" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=982 /SigmaFactorBS="tttgtttttgcctgctttgttcttgactaaacCGAATAtttg ccatggacaagACATATGATGTACAAACCCaacgaatgcaaaggatgatggcaatgag t" /listShort="spoIVFA, spoIVFB" /listLong="NA, rplU, ysxB, rpmA, S1059, S1058, spo0B, obg, yszB, pheA" /label="promotor_-10" upshifts complement(2481985) /Source="Nicolas_upshifts" /id="U2164" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=982 /SigmaFactorBS="tttgtttttgcctgctttgttcttgactaaacCGAATAtttg ccatggacaagACATATGATGTACAAACCCaacgaatgcaaaggatgatggcaatgag t" /listShort="spoIVFA, spoIVFB" /listLong="NA, rplU, ysxB, rpmA, S1059, S1058, spo0B, obg, yszB, pheA" /label="upshifts" promotor_-35 complement(2482008..2482013) /Source="Nicolas_upshift_promotors" /id="U2164" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=982 /SigmaFactorBS="tttgtttttgcctgctttgttcttgactaaacCGAATAtttg ccatggacaagACATATGATGTACAAACCCaacgaatgcaaaggatgatggcaatgag t" /listShort="spoIVFA, spoIVFB" /listLong="NA, rplU, ysxB, rpmA, S1059, S1058, spo0B, obg, yszB, pheA" /label="promotor_-35" upshifts 2482019 /Source="Nicolas_upshifts" /id="U2165" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.536463536463537" /psig="0.242757242757243" /xcortree=281 /SigmaFactorBS="tcctttgcattcgttgggtttgtacatcatatgtcttgtcca tggcaaatattcggtttagtcaagaacaaagcaggcaaaaacaaaaaaaacctgacac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2482062 /Source="Nicolas_upshifts" /id="D1433" /incds=0 /nref=2 /ntot=27 /MaxReadThrough="1.68429" /MaxDrop="7.01891" /score="-6.66807377" /energy="-6.9" /TU="U2165" /idTUdmin="U2165" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" downshifts complement(2482097) /Source="Nicolas_upshifts" /id="D1434" /incds=0 /nref=236 /ntot=262 /MaxReadThrough="2.68001" /MaxDrop="5.80551" /score="40.3102023" /energy="-12.6" /TU="U2166" /idTUdmin="U2167" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS complement(2482100..2482906) /gene="minD" /locus_tag="BSU_27990" /old_locus_tag="BSU27990" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11886553, 12426398, 12492852, 12492861, 16322744, 16885474, 17513368, 19019154, 28674273" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11886553, 12426398, 12492852, 12492861, 16322744, 16885474, 17513368, 19019154, 28674273; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="ATPase activator of MinC" /protein_id="NP_390677.1" /db_xref="EnsemblGenomes-Gn:BSU27990" /db_xref="EnsemblGenomes-Tr:CAB14759" /db_xref="GOA:Q01464" /db_xref="InterPro:IPR002586" /db_xref="InterPro:IPR010223" /db_xref="InterPro:IPR025501" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10330" /db_xref="UniProtKB/Swiss-Prot:Q01464" /translation="MGEAIVITSGKGGVGKTTTSANLGTALAILGKRVCLVDTDIGLR NLDVVMGLENRIIYDLVDVVEGRCKMHQALVKDKRFDDLLYLMPAAQTSDKTAVAPEQ IKNMVQELKQEFDYVIIDCPAGIEQGYKNAVSGADKAIVVTTPEISAVRDADRIIGLL EQEENIEPPRLVVNRIRNHLMKNGDTMDIDEIVQHLSIDLLGIVADDDEVIKASNHGE PIAMDPKNRASIAYRNIARRILGESVPLQVLEEQNKGMMAKIKSFFGVRS*" /label="minD CDS" gene complement(2482100..2482906) /gene="minD" /locus_tag="BSU_27990" /old_locus_tag="BSU27990" /label="minD gene" CDS complement(2482908..2483588) /gene="minC" /locus_tag="BSU_28000" /old_locus_tag="BSU28000" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10411726, 12426398, 12446561, 15317782, 16322744, 17326815, 19141479, 20352045, 22720735, 24366721" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10411726, 12426398, 12446561, 15317782, 16322744, 17326815, 19141479, 20352045, 22720735, 24366721; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell-division regulator (septum placement)" /protein_id="NP_390678.1" /db_xref="EnsemblGenomes-Gn:BSU28000" /db_xref="EnsemblGenomes-Tr:CAB14760" /db_xref="GOA:Q01463" /db_xref="InterPro:IPR005526" /db_xref="InterPro:IPR013033" /db_xref="InterPro:IPR036145" /db_xref="PDB:2M4I" /db_xref="SubtiList:BG10329" /db_xref="UniProtKB/Swiss-Prot:Q01463" /translation="MKTKKQQYVTIKGTKNGLTLHLDDACSFDELLDGLQNMLSIEQY TDGKGQKISVHVKLGNRFLYKEQEEQLTELIASKKDLFVHSIDSEVITKKEAQQIREE AEIISVSKIVRSGQVLQVKGDLLLIGDVNPGGTVRAGGNIFVLGSLKGIAHAGFNGNN QAVIAASEMLPTQLRINHVLNRSPDHIQKGNEMECAYLDTDGNMVIERLQHLAHLRPD LTRLEGGM*" /label="minC CDS" gene complement(2482908..2483588) /gene="minC" /locus_tag="BSU_28000" /old_locus_tag="BSU28000" /label="minC gene" CDS complement(2483641..2484159) /gene="mreD" /locus_tag="BSU_28010" /old_locus_tag="BSU28010" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15849754, 16101995, 16850406, 18156271" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16101995, 16850406, 18156271; Product type s: structure" /codon_start=1 /transl_table=11 /product="cell-shape determining protein" /protein_id="NP_390679.1" /db_xref="EnsemblGenomes-Gn:BSU28010" /db_xref="EnsemblGenomes-Tr:CAB14761" /db_xref="GOA:Q01467" /db_xref="InterPro:IPR007227" /db_xref="SubtiList:BG10328" /db_xref="UniProtKB/Swiss-Prot:Q01467" /translation="MKRFLLPFVMMLVFSAESIFTDLVHFPFVTDDQVLAPRFLMLVL IFMSAFINQKHAMIYGFIFGFLYDMNYTSLLGVYMFGFAGLCYLASKAFKVLHTNAFV VILIAVLAVCLLEFYVFGIQSLIHKDIMTFNGFVLDRFIPTILLNIAAALILVLPFRL FFMSLKKELRDE*" /label="mreD CDS" gene complement(2483641..2484159) /gene="mreD" /locus_tag="BSU_28010" /old_locus_tag="BSU28010" /label="mreD gene" CDS complement(2484156..2485028) /gene="mreC" /locus_tag="BSU_28020" /old_locus_tag="BSU28020" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15849754, 16101995, 16850406, 17427287, 20623345" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16101995, 16850406, 17427287, 20623345; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell-shape determining protein" /protein_id="NP_390680.2" /db_xref="EnsemblGenomes-Gn:BSU28020" /db_xref="EnsemblGenomes-Tr:CAB14762" /db_xref="GOA:Q01466" /db_xref="InterPro:IPR007221" /db_xref="SubtiList:BG10327" /db_xref="UniProtKB/Swiss-Prot:Q01466" /translation="MPNKRLMLLLLCIIILVAMIGFSLKGGRNTTWPEKVIGDTTGVF QNIFHTPAEFFAGIFENINDLKNTYKENERLREKLDGQTQYEAKLQELEEENKSLRDE LGHVKSIKDYKPILATVIARSPDNWAKQVTINKGTQQNVAKDMAVTNEKGALIGKIKS SGLNNFTSAVQLLSDTDRNNRVATKISGKKGSKGYGLIEGYDKEKKRLKMTIIERKDK QDVKKGDLIETSGTGGVFPEGLTIGEVTDIESDSYGLTKVAYVKPAADLTDLNNVIVV NRDVPTVDTEEEGS*" /label="mreC CDS" gene complement(2484156..2485028) /gene="mreC" /locus_tag="BSU_28020" /old_locus_tag="BSU28020" /label="mreC gene" CDS complement(2485059..2486072) /gene="mreB" /locus_tag="BSU_28030" /old_locus_tag="BSU28030" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:14588250, 15745453, 15922599, 16322744, 16885474, 17064365, 17513368, 22166997, 24550515, 27376153, 28589952" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14588250, 15745453, 15922599, 16322744, 16885474, 17064365, 17513368, 22166997, 24550515, 27376153, 28589952; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="cell-shape determining protein" /protein_id="NP_390681.2" /db_xref="EnsemblGenomes-Gn:BSU28030" /db_xref="EnsemblGenomes-Tr:CAB14763" /db_xref="GOA:Q01465" /db_xref="InterPro:IPR004753" /db_xref="SubtiList:BG10326" /db_xref="UniProtKB/Swiss-Prot:Q01465" /translation="MFGIGARDLGIDLGTANTLVFVKGKGIVVREPSVVALQTDTKSI VAVGNDAKNMIGRTPGNVVALRPMKDGVIADYETTATMMKYYINQAIKNKGMFARKPY VMVCVPSGITAVEERAVIDATRQAGARDAYPIEEPFAAAIGANLPVWEPTGSMVVDIG GGTTEVAIISLGGIVTSQSIRVAGDEMDDAIINYIRKTYNLMIGDRTAEAIKMEIGSA EAPEESDNMEIRGRDLLTGLPKTIEITGKEISNALRDTVSTIVEAVKSTLEKTPPELA ADIMDRGIVLTGGGALLRNLDKVISEETKMPVLIAEDPLDCVAIGTGKALEHIHLFKG KTR*" /label="mreB CDS" gene complement(2485059..2486072) /gene="mreB" /locus_tag="BSU_28030" /old_locus_tag="BSU28030" /label="mreB gene" upshifts complement(2486113) /Source="Nicolas_upshifts" /id="U2166" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.380619380619381" /psig="0.897102897102897" /xcortree=2535 /SigmaFactorBS="atatttgtaacactttttttttcgtcgaatTAAGCTATAATA GAGTTTAtgagtttttccctttagggtatttttgctttaagaaaggaagatacataca t" /listShort="mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(2486125..2486143) /Source="Nicolas_upshift_promotors" /id="U2166" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.380619380619381" /psig="0.897102897102897" /xcortree=2535 /SigmaFactorBS="atatttgtaacactttttttttcgtcgaatTAAGCTATAATA GAGTTTAtgagtttttccctttagggtatttttgctttaagaaaggaagatacataca t" /listShort="mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(2486164..2486859) /gene="ysxA" /locus_tag="BSU_28040" /old_locus_tag="BSU28040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10652786, 17434969, 18556794; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="conserved nucleotide-related metabolism protein" /protein_id="NP_390682.1" /db_xref="EnsemblGenomes-Gn:BSU28040" /db_xref="EnsemblGenomes-Tr:CAB14764" /db_xref="GOA:Q02170" /db_xref="InterPro:IPR000445" /db_xref="InterPro:IPR001405" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR020891" /db_xref="InterPro:IPR025657" /db_xref="SubtiList:BG10325" /db_xref="UniProtKB/Swiss-Prot:Q02170" /translation="MVIHDLPLKLKDFPMKEKPRERLLKVGAENLANHELLAILLRTG TKHESVLDLSNRLLRSFDGLRLLKEASVEELSSIPGIGMVKAIQILAAVELGSRIHKL ANEEHFVIRSPEDGANLVMEDMRFLTQEHFVCLYLNTKNQVIHKRTVFIGSLNSSIVH PREVFKEAFKRSAASFICVHNHPSGDPTPSREDIEVTRRLFECGNLIGIELLDHLVIG DKKFVSLKEKGYL*" /label="ysxA CDS" gene complement(2486164..2486859) /gene="ysxA" /locus_tag="BSU_28040" /old_locus_tag="BSU28040" /label="ysxA gene" CDS complement(2486896..2487465) /gene="maf" /locus_tag="BSU_28050" /old_locus_tag="BSU28050" /EC_number="3.6.1.9" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10841541, 16216582, 21564336, 24210219" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10841541, 16216582, 21564336, 24210219; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nucleoside triphosphate pyrophosphatase; septum formation DNA-binding protein (multicopy associated filamentation)" /protein_id="NP_390683.1" /db_xref="EnsemblGenomes-Gn:BSU28050" /db_xref="EnsemblGenomes-Tr:CAB14765" /db_xref="GOA:Q02169" /db_xref="InterPro:IPR003697" /db_xref="InterPro:IPR029001" /db_xref="PDB:1EX2" /db_xref="PDB:1EXC" /db_xref="PDB:4HEB" /db_xref="SubtiList:BG10324" /db_xref="UniProtKB/Swiss-Prot:Q02169" /translation="MTKPLILASQSPRRKELLDLLQLPYSIIVSEVEEKLNRNFSPEE NVQWLAKQKAKAVADLHPHAIVIGADTMVCLDGECLGKPQDQEEAASMLRRLSGRSHS VITAVSIQAENHSETFYDKTEVAFWSLSEEEIWTYIETKEPMDKAGAYGIQGRGALFV KKIDGDYYSVMGLPISKTMRALRHFDIRA*" /label="maf CDS" gene complement(2486896..2487465) /gene="maf" /locus_tag="BSU_28050" /old_locus_tag="BSU28050" /label="maf gene" promotor_-10 complement(2487317..2487332) /Source="Nicolas_upshift_promotors" /id="U2167" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1656 /SigmaFactorBS="ttattgtcagtgaagtagaagaaaaattaaatCGAAACTTTT caccagaagaaaACGTCCAATGGTTGGCaaaacaaaaagctaaggctgtagctgatct c" /listShort="radC, mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2487326) /Source="Nicolas_upshifts" /id="U2167" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1656 /SigmaFactorBS="ttattgtcagtgaagtagaagaaaaattaaatCGAAACTTTT caccagaagaaaACGTCCAATGGTTGGCaaaacaaaaagctaaggctgtagctgatct c" /listShort="radC, mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2487345..2487354) /Source="Nicolas_upshift_promotors" /id="U2167" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1656 /SigmaFactorBS="ttattgtcagtgaagtagaagaaaaattaaatCGAAACTTTT caccagaagaaaACGTCCAATGGTTGGCaaaacaaaaagctaaggctgtagctgatct c" /listShort="radC, mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2487504..2487523) /Source="Nicolas_upshift_promotors" /id="U2168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.296703296703297" /psig=1 /xcortree=2191 /SigmaFactorBS="ctttttttattttgtcatgaaaaagttatttttctgaAATTG TGacaagcctcgtgaTTTGGTAGGATAAACGAGTAtctttttttcttaagcaaaccct g" /listShort="maf, radC, mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2487520) /Source="Nicolas_upshifts" /id="U2168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.296703296703297" /psig=1 /xcortree=2191 /SigmaFactorBS="ctttttttattttgtcatgaaaaagttatttttctgaAATTG TGacaagcctcgtgaTTTGGTAGGATAAACGAGTAtctttttttcttaagcaaaccct g" /listShort="maf, radC, mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2487537..2487543) /Source="Nicolas_upshift_promotors" /id="U2168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.296703296703297" /psig=1 /xcortree=2191 /SigmaFactorBS="ctttttttattttgtcatgaaaaagttatttttctgaAATTG TGacaagcctcgtgaTTTGGTAGGATAAACGAGTAtctttttttcttaagcaaaccct g" /listShort="maf, radC, mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2487616) /Source="Nicolas_upshifts" /id="D1435" /incds=0 /nref=41 /ntot=100 /MaxReadThrough="1.92542" /MaxDrop="5.77117" /score="8.94061802" /energy="-7.4" /TU="NA" /idTUdmin="U2169" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(2487618..2488616) /gene="spoIIB" /locus_tag="BSU_28060" /old_locus_tag="BSU28060" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16959571, 17376078, 22720735, 22882546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16959571, 17376078, 22720735, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spatial and temporal regulator of the dissolution of septal peptidoglycan during engulfment (stage II sporulation)" /protein_id="NP_390684.1" /db_xref="EnsemblGenomes-Gn:BSU28060" /db_xref="EnsemblGenomes-Tr:CAB14766" /db_xref="GOA:P37575" /db_xref="InterPro:IPR007730" /db_xref="InterPro:IPR036680" /db_xref="SubtiList:BG10912" /db_xref="UniProtKB/Swiss-Prot:P37575" /translation="MKKRKNKKNSKAAEKALKVTINGKEETVYEQETPETEANKSMTF SNWEEKRQAEQEVAASQEHPDEDEFNWDSEEDKVFKEDPKVVPPFQKKKTKLYAKGKT GAAKPVKRVAATIAFAAVIGTGLGLFALNISGNKEASAPASLEDSLGSQTAKAGDTSA DKQTSGAEKQAAQTEGTYKTYAVQAGKFSNEKGAETLTEQLTEKGYSAVSLSKDDGYT YVIAGLASEKEVSQQLGQVLIDSDFEAWGGKELSLSIESDMTDSFKETAELAAKAILD EDITKASVEKIEKSLGETKASETGEKKAILQALKELEDPSAEAGWKAQQELLAVVK*" /label="spoIIB CDS" gene complement(2487618..2488616) /gene="spoIIB" /locus_tag="BSU_28060" /old_locus_tag="BSU28060" /label="spoIIB gene" promotor_-10 complement(2488663..2488682) /Source="Nicolas_upshift_promotors" /id="U2169" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.95104895104895" /psig="0.999000999001" /xcortree=443 /SigmaFactorBS="aacgttttttggacaaggcgacaaaagtctTGTTCTTTtttt ctttgccTGTGCTAAAGTGTGTAGCATgaaaagccgacaagaacggtcaagcaaatga a" /listShort="spoIIB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2488671) /Source="Nicolas_upshifts" /id="U2169" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.95104895104895" /psig="0.999000999001" /xcortree=443 /SigmaFactorBS="aacgttttttggacaaggcgacaaaagtctTGTTCTTTtttt ctttgccTGTGCTAAAGTGTGTAGCATgaaaagccgacaagaacggtcaagcaaatga a" /listShort="spoIIB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2488694..2488701) /Source="Nicolas_upshift_promotors" /id="U2169" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.95104895104895" /psig="0.999000999001" /xcortree=443 /SigmaFactorBS="aacgttttttggacaaggcgacaaaagtctTGTTCTTTtttt ctttgccTGTGCTAAAGTGTGTAGCATgaaaagccgacaagaacggtcaagcaaatga a" /listShort="spoIIB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2488739) /Source="Nicolas_upshifts" /id="D1436" /incds=0 /nref=1 /ntot=56 /MaxReadThrough="3.18314" /MaxDrop="2.89774" /score="11.209969" /energy="-7.6" /TU="U2170" /idTUdmin="U2170" /TUdmin="-440" /isTUend="FALSE" /label="downshifts" CDS complement(2488750..2489496) /gene="comC" /locus_tag="BSU_28070" /old_locus_tag="BSU28070" /EC_number="3.4.23.43" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2553669, 9723928, 15849754, 16751195, 16850406, 16751195" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2553669, 9723928, 15849754, 16751195, 16850406, 16751195; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="membrane prepilin peptidase" /protein_id="NP_390685.2" /db_xref="EnsemblGenomes-Gn:BSU28070" /db_xref="EnsemblGenomes-Tr:CAB14767" /db_xref="GOA:P15378" /db_xref="InterPro:IPR000045" /db_xref="InterPro:IPR010627" /db_xref="SubtiList:BG10323" /db_xref="UniProtKB/Swiss-Prot:P15378" /translation="MLSILFIFGLILGSFYYTAGCRIPLHLSIIAPRSSCPFCRRTLT PAELIPILSFLFQKGKCKSCGHRISFMYPAAELVTACLFAAAGIRFGISLELFPAVVF ISLLIIVAVTDIHFMLIPNRILIFFLPFLAAARLISPLDSWYAGLLGAAAGFLFLAVI AAITHGGVGGGDIKLFAVIGFVLGVKMLAAAFFFSVLIGALYGAAAVLTGRLAKRQPL PFAPAIAAGSILAYLYGDSIISFYIKMALG*" /label="comC CDS" gene complement(2488750..2489496) /gene="comC" /locus_tag="BSU_28070" /old_locus_tag="BSU28070" /label="comC gene" promotor_-10 complement(2489524..2489543) /Source="Nicolas_upshift_promotors" /id="U2170" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.675324675324675" /psig="0.99000999000999" /xcortree=2963 /SigmaFactorBS="tttcatgtgtaaaattgaatattcccAATTGGAGctcaggat gtccatTTTGCTACAATCCATACCAGaactcaatgagtaaaggtgtgttgtctatgct a" /listShort="comC, spoIIB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2489531) /Source="Nicolas_upshifts" /id="U2170" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.675324675324675" /psig="0.99000999000999" /xcortree=2963 /SigmaFactorBS="tttcatgtgtaaaattgaatattcccAATTGGAGctcaggat gtccatTTTGCTACAATCCATACCAGaactcaatgagtaaaggtgtgttgtctatgct a" /listShort="comC, spoIIB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2489558..2489565) /Source="Nicolas_upshift_promotors" /id="U2170" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.675324675324675" /psig="0.99000999000999" /xcortree=2963 /SigmaFactorBS="tttcatgtgtaaaattgaatattcccAATTGGAGctcaggat gtccatTTTGCTACAATCCATACCAGaactcaatgagtaaaggtgtgttgtctatgct a" /listShort="comC, spoIIB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2489636..2490928) /gene="folC" /locus_tag="BSU_28080" /old_locus_tag="BSU28080" /EC_number="6.3.2.17" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2105929, 2985605, 3040739, 6994831, 9098041, 15705579, 22720735, 26443588; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="folyl-polyglutamate synthase" /protein_id="NP_390686.1" /db_xref="EnsemblGenomes-Gn:BSU28080" /db_xref="EnsemblGenomes-Tr:CAB14768" /db_xref="GOA:Q05865" /db_xref="InterPro:IPR001645" /db_xref="InterPro:IPR004101" /db_xref="InterPro:IPR013221" /db_xref="InterPro:IPR018109" /db_xref="InterPro:IPR036565" /db_xref="InterPro:IPR036615" /db_xref="SubtiList:BG10322" /db_xref="UniProtKB/Swiss-Prot:Q05865" /translation="MFTAYQDARSWIHGRLKFGVKPGLGRMKQLMARLGHPEKKIRAF HVAGTNGKGSTVAFIRSMLQEAGYTVGTFTSPYIITFNERISVNGIPISDEEWTALVN QMKPHVEALDQTEYGQPTEFEIMTACAFLYFAEFHKVDFVIFETGLGGRFDSTNVVEP LLTVITSIGHDHMNILGNTIEEIAGEKAGIIKEGIPIVTAVTQPEALQVIRHEAERHA APFQSLHDACVIFNEEALPAGEQFSFKTEEKCYEDIRTSLIGTHQRQNAALSILAAEW LNKENIAHISDEALRSGLVKAAWPGRLELVQEHPPVYLDGAHNEEGVEKLAETMKQRF ANSRISVVFSALKDKPYQNMIKRLETIAHAIHFASFDFPRASLAKDLYDASEISNKSW SEDPDDVIKFIESKKGSNEIVLITGSLYFISDIRKRLK*" /label="folC CDS" gene complement(2489636..2490928) /gene="folC" /locus_tag="BSU_28080" /old_locus_tag="BSU28080" /label="folC gene" downshifts complement(2489641) /Source="Nicolas_upshifts" /id="D1437" /incds=0 /nref=1 /ntot=121 /MaxReadThrough="1.66565" /MaxDrop="3.18428" /score="24.7086033" /energy="-14.3" /TU="NA" /idTUdmin="U2171" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2490929..2490987) /Source="Nicolas_S_feature" /locus_tag="new_2866605_2866663_c" /HighExp="S0, LBGexp, G150, MG 45, G135, G180, Gly, Oxctl, M0t45, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig=1 /label="S1060" CDS complement(2490988..2493630) /gene="valS" /locus_tag="BSU_28090" /old_locus_tag="BSU28090" /EC_number="6.1.1.9" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9098041, 11114335, 25310979" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9098041, 11114335, 25310979; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="valyl-tRNA synthetase" /protein_id="NP_390687.2" /db_xref="EnsemblGenomes-Gn:BSU28090" /db_xref="EnsemblGenomes-Tr:CAB14769" /db_xref="GOA:Q05873" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR002300" /db_xref="InterPro:IPR002303" /db_xref="InterPro:IPR009008" /db_xref="InterPro:IPR009080" /db_xref="InterPro:IPR010978" /db_xref="InterPro:IPR013155" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR019499" /db_xref="InterPro:IPR033705" /db_xref="InterPro:IPR037118" /db_xref="SubtiList:BG10321" /db_xref="UniProtKB/Swiss-Prot:Q05873" /translation="METNEQTMPTKYDPAAVEKDRYDFWLKGKFFEAGSDQTKEPYSV VIPPPNVTGRLHLGHAWDTTLQDIVTRMKRMQGYDVLWLPGMDHAGIATQAKVEAKLR EEGKSRYDLGREKFLEETWKWKEEYADFIRSQWAKLGLGLDYSRERFTLDEGLSKAVR EVFVKLYEKGLIYRGEYIINWDPATKTALSDIEVIYKDVQGAFYHMSYPLADGSGSIE IATTRPETMLGDTAVAVHPEDERYKHLIGKTVILPIVNREIPIVGDDYVDMEFGSGAV KITPAHDPNDFELGNRHNLERILVMNEDGTMNENALQYQGMDRFECRKKLVKDLQEAG VLFKIEDHMHSVGHSERSGAVVEPYLSTQWFVRMQPLADAAIELQKKEEKVNFVPDRF EKTYLHWMENIRDWCISRQLWWGHRIPAWYHKETGELYVGLEAPEDSENWEQDTDVLD TWFSSALWPFSTMGWPDVTAEDFKRYYPTDVLVTGYDIIFFWVSRMIFQGIEFTGERP FKDVLIHGLIRDEQGRKMSKSLGNGVDPMDVIDKYGADSLRYFLATGSSPGQDLRFSY EKVESTWNFANKIWNASRFALMNMDGMTYDELDLSGEKSVADKWILTRLNETIEHVTQ LADRYEFGEVGRHLYNFIWDDFCDWYIEMAKLPLYGEDEAAKKTTRSILAYVLDQTMR LLHPFMPFLTEEIWQHLPHQGESITVSQWPAVVPEHTDTEAAADMKLLVELIRSVRNI RSEVNTPMSKQVELYIKTSTDEIASRLEANRSYVERFTNPSVLKIGTDIEAVDKAMTA VVSGAEVILPLEGLINIDEEIARLQKEFDKLTKEVERVQKKLGNEGFMKKAPAHVIDE EREKEKDYVAKRDAVQKRMAELKG*" /label="valS CDS" gene complement(2490988..2493630) /gene="valS" /locus_tag="BSU_28090" /old_locus_tag="BSU28090" /label="valS gene" S_feature complement(2493631..2493689) /Source="Nicolas_S_feature" /locus_tag="new_2869307_2869365_c" /HighExp="G150, G180, LBGexp, Oxctl, G135, dia0, HPh, Lbexp, Paraq, MG 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-, SigEF" /TUshortPSig="1, 0.012, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1061" misc_RNA complement(2493690..2493912) /gene="tboV" /locus_tag="BSU_misc_RNA_44" /product="T-box riboswitch specific of valine tRNA" /experiment="publication(s) with functional evidences, PMID:1317842, 9098041, 12165569, 12547201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1317842, 9098041, 12165569, 12547201; Product type n: RNA" /function="16.3: Control" /label="tboV RNA" gene complement(2493690..2493912) /gene="tboV" /locus_tag="BSU_misc_RNA_44" /label="tboV gene" downshifts complement(2493733) /Source="Nicolas_upshifts" /id="D1438" /incds=0 /nref=9 /ntot=27 /MaxReadThrough="6.76593" /MaxDrop="4.53149" /score="23.9897385" /energy="-20" /TU="U2171,U2173,U2176" /idTUdmin="U2176" /TUdmin="-726" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2493941..2493960) /Source="Nicolas_upshift_promotors" /id="U2171" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2387 /SigmaFactorBS="tctgtatagaaagcggtgtttttggaaaagatgATTGACgaa tcaaaaacactTTTACTATAATAAAGAACATaaataatgtatacaatgagctgataaa t" /listShort="NA, S1061, valS, S1060, folC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2493953) /Source="Nicolas_upshifts" /id="U2171" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2387 /SigmaFactorBS="tctgtatagaaagcggtgtttttggaaaagatgATTGACgaa tcaaaaacactTTTACTATAATAAAGAACATaaataatgtatacaatgagctgataaa t" /listShort="NA, S1061, valS, S1060, folC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2493955..2494063) /Source="Nicolas_S_feature" /locus_tag="new_2869631_2869739_c" /HighExp="S8, S6, S7, S5, B36, LoTm, S4, S3, BT, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigEF" /TUshortPSig="0.012, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1062" promotor_-35 complement(2493975..2493980) /Source="Nicolas_upshift_promotors" /id="U2171" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2387 /SigmaFactorBS="tctgtatagaaagcggtgtttttggaaaagatgATTGACgaa tcaaaaacactTTTACTATAATAAAGAACATaaataatgtatacaatgagctgataaa t" /listShort="NA, S1061, valS, S1060, folC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2494017..2494026 /Source="Nicolas_upshift_promotors" /id="U2172" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1272 /SigmaFactorBS="tcatcttttccaaaaacaccgctttctatacagatggGCAGG CACCTattgcccaagttTACATATGATGCTTGTAAATgcgtagaggaggatgcaccgt g" /listShort="yszA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2494039..2494058 /Source="Nicolas_upshift_promotors" /id="U2172" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1272 /SigmaFactorBS="tcatcttttccaaaaacaccgctttctatacagatggGCAGG CACCTattgcccaagttTACATATGATGCTTGTAAATgcgtagaggaggatgcaccgt g" /listShort="yszA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2494040 /Source="Nicolas_upshifts" /id="U2172" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1272 /SigmaFactorBS="tcatcttttccaaaaacaccgctttctatacagatggGCAGG CACCTattgcccaagttTACATATGATGCTTGTAAATgcgtagaggaggatgcaccgt g" /listShort="yszA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2494056..2494070) /Source="Nicolas_upshift_promotors" /id="U2173" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.98001998001998" /psig="0.011988011988012" /xcortree=1270 /SigmaFactorBS="gccttacccatggcggcagcgaataagagctgaaacgtttcT TCACggtgcatCCTCCTCTACGCATTtacaagcatcatatgtaaacttgggcaatagg t" /listShort="S1062, NA, S1061, valS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2494063) /Source="Nicolas_upshifts" /id="U2173" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.98001998001998" /psig="0.011988011988012" /xcortree=1270 /SigmaFactorBS="gccttacccatggcggcagcgaataagagctgaaacgtttcT TCACggtgcatCCTCCTCTACGCATTtacaagcatcatatgtaaacttgggcaatagg t" /listShort="S1062, NA, S1061, valS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2494078..2494082) /Source="Nicolas_upshift_promotors" /id="U2173" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.98001998001998" /psig="0.011988011988012" /xcortree=1270 /SigmaFactorBS="gccttacccatggcggcagcgaataagagctgaaacgtttcT TCACggtgcatCCTCCTCTACGCATTtacaagcatcatatgtaaacttgggcaatagg t" /listShort="S1062, NA, S1061, valS" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2494078..2494269 /gene="yszA" /locus_tag="BSU_28099" /old_locus_tag="BSU28099" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097770.1" /db_xref="EnsemblGenomes-Gn:BSU28099" /db_xref="EnsemblGenomes-Tr:CAX52676" /db_xref="GOA:C0H465" /db_xref="UniProtKB/Swiss-Prot:C0H465" /translation="MKKRFSSYSLPPWVRQIRLVSAQVIIPITIFQGIRTIFFPTTFD VLLLAILIFLACALHLEWI*" /label="yszA CDS" gene 2494078..2494269 /gene="yszA" /locus_tag="BSU_28099" /old_locus_tag="BSU28099" /label="yszA gene" CDS complement(2494288..2495313) /gene="cotN" /locus_tag="BSU_28100" /old_locus_tag="BSU28100" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16371471, 16390444, 22091839" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16371471, 16390444, 22091839; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein" /protein_id="NP_390688.1" /db_xref="EnsemblGenomes-Gn:BSU28100" /db_xref="EnsemblGenomes-Tr:CAB14770" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR014253" /db_xref="SubtiList:BG10347" /db_xref="UniProtKB/Swiss-Prot:P37964" /translation="MEDTQSVLQEYGLTAQFIEPVSPLVWKVYTDYGIFALKKLKEGR GKHFTDHMVAIEEKGFRSFVPVYRTNSGEFFSAGIQYGDIYYLMPWLQFDQEEERDQK HAYLFRETARLHERTAQELKVRRDEIERYYGQTKKKWEQDKIFYEQFVDRAEKEWYLS PFELQAITYFSETISAVNFALERLEDWYESAKEKDVSRVVMNHGSLSIHHFLYNDAGT GYFTNFERASVGPPQNDLLGFYTKMFRGFPKACPECVEWFYGYTKSFPLREAEVSLFL SYMAYPAAMYKVLNGYQTGKRQHEKEECTQLLKAYWQMKNIEPFVMKIHQIEQEKKFQ AENESTS*" /label="cotN CDS" gene complement(2494288..2495313) /gene="cotN" /locus_tag="BSU_28100" /old_locus_tag="BSU28100" /label="cotN gene" downshifts complement(2494318) /Source="Nicolas_upshifts" /id="D1439" /incds=0 /nref=23 /ntot=70 /MaxReadThrough="4.44965" /MaxDrop="6.68961" /score="-7.46388093" /energy="-12.1" /TU="U2176" /idTUdmin="U2176" /TUdmin="-1311" /isTUend="FALSE" /label="downshifts" CDS complement(2495346..2497073) /gene="spoVID" /locus_tag="BSU_28110" /old_locus_tag="BSU28110" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11325931, 16371471, 16950916, 22773792, 23178679" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11325931, 16371471, 16950916, 22773792, 23178679; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="morphogenetic spore protein (stage VI sporulation)" /protein_id="NP_390689.1" /db_xref="EnsemblGenomes-Gn:BSU28110" /db_xref="EnsemblGenomes-Tr:CAB14771" /db_xref="GOA:P37963" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG10346" /db_xref="UniProtKB/Swiss-Prot:P37963" /translation="MPQNHRLQFSVEESICFQKGQEVSELLSISLDPDIRVQEVNDYV SIIGSLELTGEYNIDQNKHTEEIYTDKRFVEQVRKREDGSAELTHCFPVDITIPKNKV SHLQDVFVFIDAFDYQLTDSRILTIQADLAIEGLLDDTQDKEPEIPLYEAPAAFREEE LSEPPAHSVVEEPGASSAEEAVLQHEPPAEPPELFISKAGLREELETEKAESEPPESV ASEPEAREDVKEEEESEELAVPETEVRAESETEESEPEPDPSEIEIQEIVKAKKETAE PAAAIADVREEADSPAETELREHVGAEESPALEAELHSETVIAKEKEETTVSPNHEYA LRQEAQNEEAAQSDQADPALCQEEAEPDEALESVSEAALSIEDSRETASAVYMENDNA DLHFHFNQKTSSEEASQEELPEPAYRTFLPEQEEEDSFYSAPKLLEEEEQEEESFEIE VRKTPSAEEPKEETPFQSFQLPESSETERKETDAVPRVAPAAETKEPQTKESDNSLYL TKLFTKEADEFSRMKICIVQQEDTIERLCERYEITSQQLIRMNSLALDDELKAGQILY IPQYKNSHA*" /label="spoVID CDS" gene complement(2495346..2497073) /gene="spoVID" /locus_tag="BSU_28110" /old_locus_tag="BSU28110" /label="spoVID gene" promotor_-35 2496675..2496678 /Source="Nicolas_upshift_promotors" /id="U2174" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.456543456543457" /psig="0.684315684315684" /xcortree=691 /SigmaFactorBS="ggctctttgtcttgcgtatcgtccaaaagcccttcGATCgct aaatcagcttgaATTGTTAAAATGCGCGAATCcgtcaattgatagtcaaatgcgtcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2496694..2496713 /Source="Nicolas_upshift_promotors" /id="U2174" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.456543456543457" /psig="0.684315684315684" /xcortree=691 /SigmaFactorBS="ggctctttgtcttgcgtatcgtccaaaagcccttcGATCgct aaatcagcttgaATTGTTAAAATGCGCGAATCcgtcaattgatagtcaaatgcgtcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2496700 /Source="Nicolas_upshifts" /id="U2174" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.456543456543457" /psig="0.684315684315684" /xcortree=691 /SigmaFactorBS="ggctctttgtcttgcgtatcgtccaaaagcccttcGATCgct aaatcagcttgaATTGTTAAAATGCGCGAATCcgtcaattgatagtcaaatgcgtcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2497069..2497073 /Source="Nicolas_upshift_promotors" /id="U2175" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=699 /SigmaFactorBS="tcttctacagaaaattgcaatcgatgattttgcGGCAAgttc atatCCTCCTTTCATCTAAtccttaaaattagatgtcactaaaggtgtatgtatgaac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2497082..2497096 /Source="Nicolas_upshift_promotors" /id="U2175" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=699 /SigmaFactorBS="tcttctacagaaaattgcaatcgatgattttgcGGCAAgttc atatCCTCCTTTCATCTAAtccttaaaattagatgtcactaaaggtgtatgtatgaac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2497096 /Source="Nicolas_upshifts" /id="U2175" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=699 /SigmaFactorBS="tcttctacagaaaattgcaatcgatgattttgcGGCAAgttc atatCCTCCTTTCATCTAAtccttaaaattagatgtcactaaaggtgtatgtatgaac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2497111..2497129) /Source="Nicolas_upshift_promotors" /id="U2176" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1091 /SigmaFactorBS="caaggactccttgtgccggttttttcgtgctctcccaCTCAT AttttctccagttcatACATACACCTTTAGTGACAtctaattttaaggattagatgaa a" /listShort="spoVID, ysxE, S1062, NA, S1061, valS" /listLong="S1060, folC" /label="promotor_-10" upshifts complement(2497127) /Source="Nicolas_upshifts" /id="U2176" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1091 /SigmaFactorBS="caaggactccttgtgccggttttttcgtgctctcccaCTCAT AttttctccagttcatACATACACCTTTAGTGACAtctaattttaaggattagatgaa a" /listShort="spoVID, ysxE, S1062, NA, S1061, valS" /listLong="S1060, folC" /label="upshifts" promotor_-35 complement(2497145..2497150) /Source="Nicolas_upshift_promotors" /id="U2176" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1091 /SigmaFactorBS="caaggactccttgtgccggttttttcgtgctctcccaCTCAT AttttctccagttcatACATACACCTTTAGTGACAtctaattttaaggattagatgaa a" /listShort="spoVID, ysxE, S1062, NA, S1061, valS" /listLong="S1060, folC" /label="promotor_-35" CDS complement(2497204..2498496) /gene="hemL" /locus_tag="BSU_28120" /old_locus_tag="BSU28120" /EC_number="5.4.3.8" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1672867, 12029044, 15802251, 16682782, 20946885, 27303897" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1672867, 12029044, 15802251, 16682782, 20946885, 27303897; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="glutamate-1-semialdehyde 2,1-aminomutase" /protein_id="NP_390690.1" /db_xref="EnsemblGenomes-Gn:BSU28120" /db_xref="EnsemblGenomes-Tr:CAB14772" /db_xref="GOA:P30949" /db_xref="InterPro:IPR004639" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="PDB:3BS8" /db_xref="SubtiList:BG10345" /db_xref="UniProtKB/Swiss-Prot:P30949" /translation="MRSYEKSKTAFKEAQKLMPGGVNSPVRAFKSVDMDPIFMERGKG SKIFDIDGNEYIDYVLSWGPLILGHTNDRVVESLKKVAEYGTSFGAPTEVENELAKLV IDRVPSVEIVRMVSSGTEATMSALRLARGYTGRNKILKFEGCYHGHGDSLLIKAGSGV ATLGLPDSPGVPEGIAKNTITVPYNDLESVKLAFQQFGEDIAGVIVEPVAGNMGVVPP QEGFLQGLRDITEQYGSLLIFDEVMTGFRVDYNCAQGYFGVTPDLTCLGKVIGGGLPV GAYGGKAEIMEQIAPSGPIYQAGTLSGNPLAMTAGLETLKQLTPESYKNFIKKGDRLE EGISKTAGAHGIPHTFNRAGSMIGFFFTNEPVINYETAKSSDLKLFASYYKGMANEGV FLPPSQFEGLFLSTAHTDEDIENTIQAAEKVFAEISRR*" /label="hemL CDS" gene complement(2497204..2498496) /gene="hemL" /locus_tag="BSU_28120" /old_locus_tag="BSU28120" /label="hemL gene" downshifts complement(2497221) /Source="Nicolas_upshifts" /id="D1440" /incds=0 /nref=144 /ntot=397 /MaxReadThrough="3.40168" /MaxDrop="7.29251" /score="3.77738386" /energy="-10.6" /TU="NA" /idTUdmin="U2177" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" CDS complement(2498526..2499500) /gene="hemB" /locus_tag="BSU_28130" /old_locus_tag="BSU28130" /EC_number="4.2.1.24" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2110138, 12029044, 15802251, 20823524, 24598743" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2110138, 12029044, 15802251, 20823524, 24598743; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="delta-aminolevulinic acid dehydratase (porphobilinogen synthase)" /protein_id="NP_390691.1" /db_xref="EnsemblGenomes-Gn:BSU28130" /db_xref="EnsemblGenomes-Tr:CAB14773" /db_xref="GOA:P30950" /db_xref="InterPro:IPR001731" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR030656" /db_xref="SubtiList:BG10344" /db_xref="UniProtKB/Swiss-Prot:P30950" /translation="MSQSFNRHRRLRTSKAMREMVKETRLHPSDFIYPIFVVEGLEGK KAVPSMPDVHHVSLDLLKDEVAELVKLGIQSVIVFGIPEEKDDCGTQAYHDHGIVQKA ITEIKEHFPEMVVVADTCLCEYTDHGHCGLVKDGVILNDESLELLAQTAVSQAKAGAD IIAPSNMMDGFVTVIREALDKEGFVNIPIMSYAVKYSSEFYGPFRDAANSTPQFGDRK TYQMDPANRMEALREAQSDVEEGADFLIVKPSLSYMDIMRDVKNEFTLPLVAYNVSGE YSMVKAAAQNGWIKEKEIVLEILTSMKRAGADLIITYHAKDAAKWLAE*" /label="hemB CDS" gene complement(2498526..2499500) /gene="hemB" /locus_tag="BSU_28130" /old_locus_tag="BSU28130" /label="hemB gene" CDS complement(2499497..2500285) /gene="hemD" /locus_tag="BSU_28140" /old_locus_tag="BSU28140" /EC_number="4.2.1.75" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1672867, 2110138, 7628476, 12029044, 12196144, 15802251" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1672867, 2110138, 7628476, 12029044, 12196144, 15802251; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="uroporphyrinogen III cosynthase" /protein_id="NP_390692.1" /db_xref="EnsemblGenomes-Gn:BSU28140" /db_xref="EnsemblGenomes-Tr:CAB14774" /db_xref="GOA:P21248" /db_xref="InterPro:IPR003754" /db_xref="InterPro:IPR036108" /db_xref="SubtiList:BG10343" /db_xref="UniProtKB/Swiss-Prot:P21248" /translation="MENDFPLKGKTVLVTRNKAQAASFQQKVEALGGKAVLTSLITFR RALPNDVAEQVREDLAAPGWLVFTSVNGADFFFSYLKENQLILPAHKKIAAVGEKTAR RLKMHNVSVDVMPQEYIAEQLADALKQHAEPGETITVMKGNLSRDVIKQELVPLGFEV KEWVLYETIPDEEGIEALKDAAGQYSFDYVTFTSSSTVHTFMHVLGEELKKWKANGTA CISIGPLTNDALLTYGITSHTPDTFTIDGMLELMCSMSREEERI*" /label="hemD CDS" gene complement(2499497..2500285) /gene="hemD" /locus_tag="BSU_28140" /old_locus_tag="BSU28140" /label="hemD gene" CDS complement(2500275..2501219) /gene="hemC" /locus_tag="BSU_28150" /old_locus_tag="BSU28150" /EC_number="2.5.1.61" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2110138, 9058548, 12029044, 15802251, 23908040, 24598743" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2110138, 9058548, 12029044, 15802251, 23908040, 24598743; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="porphobilinogen deaminase (hydroxymethylbilane synthase)" /protein_id="NP_390693.1" /db_xref="EnsemblGenomes-Gn:BSU28150" /db_xref="EnsemblGenomes-Tr:CAB14775" /db_xref="GOA:P16616" /db_xref="InterPro:IPR000860" /db_xref="InterPro:IPR022417" /db_xref="InterPro:IPR022418" /db_xref="InterPro:IPR022419" /db_xref="InterPro:IPR036803" /db_xref="SubtiList:BG10342" /db_xref="UniProtKB/Swiss-Prot:P16616" /translation="MMRTIKVGSRRSKLAMTQTKWVIQKLKEINPSFAFEIKEIVTKG DRIVDVTLSKVGGKGLFVKEIEQALLNEEIDMAVHSMKDMPAVLPEGLVIGCIPERED PRDALISKNRVKLSEMKKGAVIGTSSLRRSAQLLIERPDLTIKWIRGNIDTRLQKLET EDYDAIILAAAGLSRMGWKQDVVTEFLEPERCLPAVGQGALAIECRESDEELLALFSQ FTDEYTKRTVLAERAFLNAMEGGCQVPIAGYSVLNGQDEIEMTGLVASPDGKIIFKET VTGNDPEEVGKRCAALMADKGAKDLIDRVKRELDEDGK*" /label="hemC CDS" gene complement(2500275..2501219) /gene="hemC" /locus_tag="BSU_28150" /old_locus_tag="BSU28150" /label="hemC gene" CDS complement(2501252..2502082) /gene="hemX" /locus_tag="BSU_28160" /old_locus_tag="BSU28160" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8012594, 12029044, 15802251, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8012594, 12029044, 15802251, 15849754, 16850406; Product type f: factor" /codon_start=1 /transl_table=11 /product="negative effector of the concentration of glutamyl-tRNA reductase HemA" /protein_id="NP_390694.2" /db_xref="EnsemblGenomes-Gn:BSU28160" /db_xref="EnsemblGenomes-Tr:CAB14776" /db_xref="GOA:P16645" /db_xref="InterPro:IPR002541" /db_xref="SubtiList:BG10341" /db_xref="UniProtKB/Swiss-Prot:P16645" /translation="MIDTAMARLNEGTIVIYALSVLFYFIDFLQHNRKAGKMAFWLLS IVWTLQTVYLAYFMWVTGRFPVLNVTEALYFYAWVLVTLSLVLTKLLRVDFIVFFTNV IGFSMIAIHTFSPTEQQSAAFSGQLVSELLVIHITMAILSYGAFSLSFVFSVLYMFQY HLLKKKKWGKWLLRIEDLSKLDYMAYVLNVIGVPMLLLSLILGVIWAYVSLETLYWFD AKVLGSFVVLLLYSYYLYIRLIKELQGKVAALWNTACFLVLMINYFLLGSLSQFHWFS *" /label="hemX CDS" gene complement(2501252..2502082) /gene="hemX" /locus_tag="BSU_28160" /old_locus_tag="BSU28160" /label="hemX gene" CDS complement(2502090..2503457) /gene="hemA" /locus_tag="BSU_28170" /old_locus_tag="BSU28170" /EC_number="1.2.1.70" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1536660, 15802251, 1672867, 2490162, 12029044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1536660, 15802251, 1672867, 2490162, 12029044; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamyl-tRNA reductase" /protein_id="NP_390695.1" /db_xref="EnsemblGenomes-Gn:BSU28170" /db_xref="EnsemblGenomes-Tr:CAB14777" /db_xref="GOA:P16618" /db_xref="InterPro:IPR000343" /db_xref="InterPro:IPR006151" /db_xref="InterPro:IPR015895" /db_xref="InterPro:IPR015896" /db_xref="InterPro:IPR018214" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR036343" /db_xref="InterPro:IPR036453" /db_xref="SubtiList:BG10340" /db_xref="UniProtKB/Swiss-Prot:P16618" /translation="MHILVVGVDYKSAPIEIREKVSFQPNELAEAMVQLKEEKSILEN IIVSTCNRTEIYAVVDQLHTGRYYIKKFLADWFQLSKEELSPFLTFYESDAAVEHLFR VACGLDSMVIGETQILGQVRDSFKTAQQEKTIGTIFNELFKQAVTVGKRTHAETDIGS NAVSVSYAAVELAKKIFGNLSSKHILILGAGKMGELAAENLHGQGIGKVTVINRTYLK AKELADRFSGEARSLNQLESALAEADILISSTGASEFVVSKEMMENANKLRKGRPLFM VDIAVPRDLDPALNDLEGVFLYDIDDLEGIVEANMKERRETAEKVELLIEETIVEFKQ WMNTLGVVPVISALREKALAIQSETMDSIERKLPHLSTREKKLLNKHTKSIINQMLRD PILKVKELAADADSEEKLALFMQIFDIEEAAGRQMMKTVESSQKVHSFKKAESKAGFS PLVSE*" /label="hemA CDS" gene complement(2502090..2503457) /gene="hemA" /locus_tag="BSU_28170" /old_locus_tag="BSU28170" /label="hemA gene" misc_feature complement(2503521..2503540) /Source="Nicolas_upshift_promotors" /id="U2177" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.932067932067932" /psig="0.999000999001" /xcortree=1604 /SigmaFactorBS="atatagcataagaattttaaaatctgttcacattttgtgaaa gaaacTATGTTATAATTATTATAAAtaatgagttctatgttagaatgattataaatta a" /listShort="hemA, hemX, hemC, hemD, hemB, hemL" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2503527) /Source="Nicolas_upshifts" /id="U2177" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.932067932067932" /psig="0.999000999001" /xcortree=1604 /SigmaFactorBS="atatagcataagaattttaaaatctgttcacattttgtgaaa gaaacTATGTTATAATTATTATAAAtaatgagttctatgttagaatgattataaatta a" /listShort="hemA, hemX, hemC, hemD, hemB, hemL" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2503529..2503618) /Source="Nicolas_S_feature" /locus_tag="new_2879205_2879294_c" /HighExp="dia15, Salt, dia5, Etha, Paraq, H2O2, Diami, Heat, LoTm, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB, SigGF" /TUshortPSig="0.997, 1, 0.948" /TUlongSig="NA" /TUlongPSig="NA" /label="S1063" misc_feature 2503578..2503597 /Source="Nicolas_upshift_promotors" /id="U2178" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.94105894105894" /psig=1 /xcortree=2409 /SigmaFactorBS="aataattataacatagtttctttcacaaaatgtgaacagatt ttaaaattctTATGCTATATTAGAAAAAGCttcagggaaaagaagcattcctattgac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2503586 /Source="Nicolas_upshifts" /id="U2178" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.94105894105894" /psig=1 /xcortree=2409 /SigmaFactorBS="aataattataacatagtttctttcacaaaatgtgaacagatt ttaaaattctTATGCTATATTAGAAAAAGCttcagggaaaagaagcattcctattgac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2503615..2503634) /Source="Nicolas_upshift_promotors" /id="U2179" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.693306693306693" /psig="0.997002997002997" /xcortree=1856 /SigmaFactorBS="ccttcttgttttttagagctgatgtGTAGTAAATttctgctg ttTTTGGTATTGTCAATAGGAAtgcttcttttccctgaagctttttctaatatagcat a" /listShort="S1063, hemA, hemX, hemC, hemD, hemB, hemL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2503618) /Source="Nicolas_upshifts" /id="U2179" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.693306693306693" /psig="0.997002997002997" /xcortree=1856 /SigmaFactorBS="ccttcttgttttttagagctgatgtGTAGTAAATttctgctg ttTTTGGTATTGTCAATAGGAAtgcttcttttccctgaagctttttctaatatagcat a" /listShort="S1063, hemA, hemX, hemC, hemD, hemB, hemL" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2503620..2504036) /Source="Nicolas_S_feature" /locus_tag="new_2879296_2879712_c" /HighExp="Etha, S5, Gly, S7, S4, S8, S6, H2O2, dia15, G135" /AntisenseName="ysxD" /AntisenseCor="-1.16761021676615E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigGF" /TUshortPSig="1, 0.948" /TUlongSig="NA" /TUlongPSig="NA" /label="S1064" promotor_-35 complement(2503645..2503653) /Source="Nicolas_upshift_promotors" /id="U2179" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.693306693306693" /psig="0.997002997002997" /xcortree=1856 /SigmaFactorBS="ccttcttgttttttagagctgatgtGTAGTAAATttctgctg ttTTTGGTATTGTCAATAGGAAtgcttcttttccctgaagctttttctaatatagcat a" /listShort="S1063, hemA, hemX, hemC, hemD, hemB, hemL" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2503687..2504184 /gene="ysxD" /locus_tag="BSU_28180" /old_locus_tag="BSU28180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390696.2" /db_xref="EnsemblGenomes-Gn:BSU28180" /db_xref="EnsemblGenomes-Tr:CAB14778" /db_xref="GOA:P40736" /db_xref="SubtiList:BG11068" /db_xref="UniProtKB/Swiss-Prot:P40736" /translation="MKQKSILFPCLLLAASVYAWLESGQAELFSGQDQWPVLLMLLGA AFVYQGKKEAVTPHFFIGLLLFGIGLHFFAKPKWVWWPDDFEMLLFMIGFSLLVSTVQ KKEYVYEAVSMICFSLFLYFFKQIMAWLESAHIPTALLKEYWPFVFIGISLLLLLIKR KKSIR*" /label="ysxD CDS" gene 2503687..2504184 /gene="ysxD" /locus_tag="BSU_28180" /old_locus_tag="BSU28180" /label="ysxD gene" promotor_-10 complement(2504020..2504038) /Source="Nicolas_upshift_promotors" /id="U2180" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=747 /SigmaFactorBS="gttggaatatgcgcagactcaagccatgccataattTGTTTG AaaaagtacaaaaacaGGGAAAAACAAATCATCGAcacagcttcatatacatattctt t" /listShort="S1064, S1063, hemA, hemX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2504036) /Source="Nicolas_upshifts" /id="U2180" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=747 /SigmaFactorBS="gttggaatatgcgcagactcaagccatgccataattTGTTTG AaaaagtacaaaaacaGGGAAAAACAAATCATCGAcacagcttcatatacatattctt t" /listShort="S1064, S1063, hemA, hemX" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2504038..2504168) /Source="Nicolas_S_feature" /locus_tag="new_2879714_2879844_c" /HighExp="S5, S4, S8, S6, H2O2, S7, Etha, dia15, Diami, G180" /AntisenseName="ysxD" /AntisenseCor="-1.18079537254433E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.948" /TUlongSig="NA" /TUlongPSig="NA" /label="S1065" promotor_-35 complement(2504054..2504060) /Source="Nicolas_upshift_promotors" /id="U2180" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=747 /SigmaFactorBS="gttggaatatgcgcagactcaagccatgccataattTGTTTG AaaaagtacaaaaacaGGGAAAAACAAATCATCGAcacagcttcatatacatattctt t" /listShort="S1064, S1063, hemA, hemX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2504148..2504159) /Source="Nicolas_upshift_promotors" /id="U2181" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1211 /SigmaFactorBS="tcaaaaaaatgataaaccggtagaggatcctctaccggtttt atttatCGTATAGatttttttcgttttATCAATAATAACaataaactgattccaataa a" /listShort="S1065, S1064, S1063" /listLong="hemA" /label="promotor_-10" upshifts complement(2504168) /Source="Nicolas_upshifts" /id="U2181" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1211 /SigmaFactorBS="tcaaaaaaatgataaaccggtagaggatcctctaccggtttt atttatCGTATAGatttttttcgttttATCAATAATAACaataaactgattccaataa a" /listShort="S1065, S1064, S1063" /listLong="hemA" /label="upshifts" promotor_-35 complement(2504174..2504180) /Source="Nicolas_upshift_promotors" /id="U2181" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1211 /SigmaFactorBS="tcaaaaaaatgataaaccggtagaggatcctctaccggtttt atttatCGTATAGatttttttcgttttATCAATAATAACaataaactgattccaataa a" /listShort="S1065, S1064, S1063" /listLong="hemA" /label="promotor_-35" CDS complement(2504206..2504793) /gene="engB" /locus_tag="BSU_28190" /old_locus_tag="BSU28190" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 16997968, 17981968, 21360172, 21636901, 25771857, 26103561, 27484475" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16997968, 17981968, 21360172, 21636901, 25771857, 26103561, 27484475; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GTPase involved in ribosome 50S subunit assembly(maturation of the central 50S protuberance)" /protein_id="NP_390697.1" /db_xref="EnsemblGenomes-Gn:BSU28190" /db_xref="EnsemblGenomes-Tr:CAB14779" /db_xref="GOA:P38424" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR019987" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030393" /db_xref="PDB:1SUL" /db_xref="PDB:1SVI" /db_xref="PDB:1SVW" /db_xref="SubtiList:BG10339" /db_xref="UniProtKB/Swiss-Prot:P38424" /translation="MKVTKSEIVISAVKPEQYPEGGLPEIALAGRSNVGKSSFINSLI NRKNLARTSSKPGKTQTLNFYIINDELHFVDVPGYGFAKVSKSEREAWGRMIETYITT REELKAVVQIVDLRHAPSNDDVQMYEFLKYYGIPVIVIATKADKIPKGKWDKHAKVVR QTLNIDPEDELILFSSETKKGKDEAWGAIKKMINR*" /label="engB CDS" gene complement(2504206..2504793) /gene="engB" /locus_tag="BSU_28190" /old_locus_tag="BSU28190" /label="engB gene" downshifts complement(2504234) /Source="Nicolas_upshifts" /id="D1441" /incds=0 /nref=78 /ntot=212 /MaxReadThrough="4.03888" /MaxDrop="6.16077" /score="19.8235959" /energy="-13.4" /TU="NA" /idTUdmin="U2182" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2504790..2507114) /gene="lonA" /locus_tag="BSU_28200" /old_locus_tag="BSU28200" /EC_number="3.4.21.53" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10411757, 11325926, 15987505, 18689473, 20600124, 21546913, 25538299, 26677871" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10411757, 11325926, 15987505, 18689473, 20600124, 21546913, 25538299, 26677871; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="class III heat-shock ATP-dependent LonA protease" /protein_id="NP_390698.1" /db_xref="EnsemblGenomes-Gn:BSU28200" /db_xref="EnsemblGenomes-Tr:CAB14780" /db_xref="GOA:P37945" /db_xref="InterPro:IPR003111" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR004815" /db_xref="InterPro:IPR008268" /db_xref="InterPro:IPR008269" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR027065" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR027543" /db_xref="PDB:1X37" /db_xref="PDB:3M65" /db_xref="PDB:3M6A" /db_xref="SubtiList:BG10338" /db_xref="UniProtKB/Swiss-Prot:P37945" /translation="MAEELKRSIPLLPLRGLLVYPTMVLHLDVGRDKSVQALEQAMMH DHMIFLATQQDISIDEPGEDEIFTVGTYTKIKQMLKLPNGTIRVLVEGLKRAHIVKYN EHEDYTSVDIQLIHEDDSKDTEDEALMRTLLDHFDQYIKISKKISAETYAAVTDIEEP GRMADIVASHLPLKLKDKQDILETADVKDRLNKVIDFINNEKEVLEIEKKIGQRVKRS MERTQKEYYLREQMKAIQKELGDKEGKTGEVQTLTEKIEEAGMPDHVKETALKELNRY EKIPSSSAESSVIRNYIDWLVALPWTDETDDKLDLKEAGRLLDEEHHGLEKVKERILE YLAVQKLTKSLKGPILCLAGPPGVGKTSLAKSIAKSLGRKFVRISLGGVRDESEIRGH RRTYVGAMPGRIIQGMKKAGKLNPVFLLDEIDKMSSDFRGDPSSAMLEVLDPEQNSSF SDHYIEETFDLSKVLFIATANNLATIPGPLRDRMEIINIAGYTEIEKLEIVKDHLLPK QIKEHGLKKSNLQLRDQAILDIIRYYTREAGVRSLERQLAAICRKAAKAIVAEERKRI TVTEKNLQDFIGKRIFRYGQAETEDQVGVVTGLAYTTVGGDTLSIEVSLSPGKGKLIL TGKLGDVMRESAQAAFSYVRSKTEELGIEPDFHEKYDIHIHVPEGAVPKDGPSAGITM ATALVSALTGRAVSREVGMTGEITLRGRVLPIGGLKEKALGAHRAGLTTIIAPKDNEK DIEDIPESVREGLTFILASHLDEVLEHALVGEKK*" /label="lonA CDS" gene complement(2504790..2507114) /gene="lonA" /locus_tag="BSU_28200" /old_locus_tag="BSU28200" /label="lonA gene" S_feature complement(2507115..2507226) /Source="Nicolas_S_feature" /locus_tag="new_2882791_2882902_c" /HighExp="Etha, dia15, LBGtran, dia5, Diami, H2O2, LBGexp, Lbexp, LoTm, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.967" /TUlongSig="NA" /TUlongPSig="NA" /label="S1066" promotor_-10 complement(2507211..2507230) /Source="Nicolas_upshift_promotors" /id="U2182" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.646353646353646" /psig="0.967032967032967" /xcortree=2001 /SigmaFactorBS="ttgataatagggtttttttcatgaaggacatctttTCCTTTT TcatatcagaaagaAAGGGTATACTACGAGGAGActgttttatagaaaatggaaccat g" /listShort="S1066, lonA, ysxC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2507226) /Source="Nicolas_upshifts" /id="U2182" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.646353646353646" /psig="0.967032967032967" /xcortree=2001 /SigmaFactorBS="ttgataatagggtttttttcatgaaggacatctttTCCTTTT TcatatcagaaagaAAGGGTATACTACGAGGAGActgttttatagaaaatggaaccat g" /listShort="S1066, lonA, ysxC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2507244..2507251) /Source="Nicolas_upshift_promotors" /id="U2182" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.646353646353646" /psig="0.967032967032967" /xcortree=2001 /SigmaFactorBS="ttgataatagggtttttttcatgaaggacatctttTCCTTTT TcatatcagaaagaAAGGGTATACTACGAGGAGActgttttatagaaaatggaaccat g" /listShort="S1066, lonA, ysxC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2507295..2508953) /gene="lonB" /locus_tag="BSU_28210" /old_locus_tag="BSU28210" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10411757, 11325926, 18689473, 26428922" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10411757, 11325926, 18689473, 26428922; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore-specific ATP-dependent protease LonB" /protein_id="NP_390699.1" /db_xref="EnsemblGenomes-Gn:BSU28210" /db_xref="EnsemblGenomes-Tr:CAB14781" /db_xref="GOA:P42425" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR008268" /db_xref="InterPro:IPR008269" /db_xref="InterPro:IPR014251" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR027065" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11077" /db_xref="UniProtKB/Swiss-Prot:P42425" /translation="MSWTGIALFIQLFFGIIIGLYFWNLLKNQRTQKVTIDKESKKEM EQLRKMRAISLSEPLSEKVRPKSFKDIVGQEDGIKALKAALCGPNPQHVIVYGPPGVG KTAAARLVLEEAKKHKQSPFKEQAVFVELDATTARFDERGIADPLIGSVHDPIYQGAG AMGQAGIPQPKQGAVTHAHGGVLFIDEIGELHPIQMNKMLKVLEDRKVFLDSAYYSEE NTQIPNHIHDIFQNGLPADFRLIGATTRMPNEIPPAIRSRCLEVFFRELEKDELKTVA KTAADKIEKNISEEGLDLLTSYTRNGREAVNMIQIAAGMAVTENRKDITIEDIEWVIH SSQLTPKHEQKIGVEPQVGIVNGLAVYGPNSGSLLEIEVSVTAAQDKGSINITGIAEE ESIGSQSKSIRRKSMAKGSVENVLTVLRTMGMKPSDYDIHINFPGGIPIDGPSAGIAM AAGIFSAIHKIPIDNTVAMTGEISLNGLVKPIGGVIPKIKAAKQSGAKKVIIPYENQQ AILKQIDGIEIIAVKTFQEVLDEILVNPPTEQKPFHIEINKESV*" /label="lonB CDS" gene complement(2507295..2508953) /gene="lonB" /locus_tag="BSU_28210" /old_locus_tag="BSU28210" /label="lonB gene" downshifts complement(2507314) /Source="Nicolas_upshifts" /id="D1442" /incds=0 /nref=24 /ntot=42 /MaxReadThrough="2.32825" /MaxDrop="4.82102" /score="7.30551887" /energy="-7.1" /TU="NA" /idTUdmin="U2183" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2508997..2509015) /Source="Nicolas_upshift_promotors" /id="U2183" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.66933066933067" /psig="0.66933066933067" /xcortree=1167 /SigmaFactorBS="aggtttttttgcatgcaactcttccggaaaaaCGTTTAttcc cgtcttctatgGGAGATACTAGCAATCAGAggaatgaattggatacataaattgtttt t" /listShort="lonB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2509008) /Source="Nicolas_upshifts" /id="U2183" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.66933066933067" /psig="0.66933066933067" /xcortree=1167 /SigmaFactorBS="aggtttttttgcatgcaactcttccggaaaaaCGTTTAttcc cgtcttctatgGGAGATACTAGCAATCAGAggaatgaattggatacataaattgtttt t" /listShort="lonB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2509031..2509036) /Source="Nicolas_upshift_promotors" /id="U2183" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.66933066933067" /psig="0.66933066933067" /xcortree=1167 /SigmaFactorBS="aggtttttttgcatgcaactcttccggaaaaaCGTTTAttcc cgtcttctatgGGAGATACTAGCAATCAGAggaatgaattggatacataaattgtttt t" /listShort="lonB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2509105..2510367) /gene="clpX" /locus_tag="BSU_28220" /old_locus_tag="BSU28220" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11395451, 11807061, 12354604, 12761164, 14679237, 15948963, 16899079, 17827297, 17981983, 18662407, 19136590, 25433860, 27014237" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11395451, 11807061, 12354604, 12761164, 14679237, 15948963, 16899079, 17827297, 17981983, 18662407, 19136590, 25433860, 27014237; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein unfolding ATPase required for presentation of proteins to proteases; Maxwell's demon" /protein_id="NP_390700.2" /db_xref="EnsemblGenomes-Gn:BSU28220" /db_xref="EnsemblGenomes-Tr:CAB14782" /db_xref="GOA:P50866" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR004487" /db_xref="InterPro:IPR010603" /db_xref="InterPro:IPR019489" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11387" /db_xref="UniProtKB/Swiss-Prot:P50866" /translation="MFKFNEEKGQLKCSFCGKTQDQVRKLVAGPGVYICDECIELCTE IVEEELGTEEEVEFKDVPKPQEIREILNEYVIGQDQAKKSLAVAVYNHYKRINSNSKV DDVELSKSNISLIGPTGSGKTLLAQTLARILNVPFAIADATSLTEAGYVGEDVENILL KLIQAADYDVEKAEKGIIYIDEIDKVARKSENPSITRDVSGEGVQQALLKILEGTVAS VPPQGGRKHPHQEFIQIDTTNILFICGGAFDGIEQIIKRRLGQKVIGFGADNKAADLE KEDLLSKVLPEDLLRFGLIPEFIGRLPVIASLEKLDEEALVAILTKPKNALVKQFKKM LELDNVELEFEEEALSEIAKKAIERKTGARGLRSIIEGIMLDVMFELPSRDDIEKCVI TGATVTHGEPPRLLLKDGTEVSQDKTSA*" /label="clpX CDS" gene complement(2509105..2510367) /gene="clpX" /locus_tag="BSU_28220" /old_locus_tag="BSU28220" /label="clpX gene" downshifts complement(2509115) /Source="Nicolas_upshifts" /id="D1443" /incds=0 /nref=256 /ntot=333 /MaxReadThrough="2.8818" /MaxDrop="7.82186" /score="40.299167" /energy="-18.9" /TU="U2185" /idTUdmin="U2184" /TUdmin="-19" /isTUend="TRUE" /label="downshifts" S_feature complement(2510368..2510457) /Source="Nicolas_S_feature" /locus_tag="new_2886044_2886133_c" /HighExp="dia15, dia5, Salt, Diami, C90, H2O2, Paraq, Oxctl, S1, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="SigA, SigA, SigA" /TUlongPSig="1, 0.998, 0.896" /label="S1067" promotor_-10 complement(2510445..2510464) /Source="Nicolas_upshift_promotors" /id="U2184" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=1875 /SigmaFactorBS="atacatatagaatgtgcaagtcagaaacacattgTTACCGTC tttttggaaagTATGGTAAAATGCAATACATactcgttcgtttcaagaatcattttct t" /listShort="S1067, clpX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2510457) /Source="Nicolas_upshifts" /id="U2184" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=1875 /SigmaFactorBS="atacatatagaatgtgcaagtcagaaacacattgTTACCGTC tttttggaaagTATGGTAAAATGCAATACATactcgttcgtttcaagaatcattttct t" /listShort="S1067, clpX" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2510459..2510590) /Source="Nicolas_S_feature" /locus_tag="new_2886135_2886266_c" /HighExp="H2O2, dia15, Paraq, Oxctl, G180, G135, HPh, G150, LPh, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigA, SigA" /TUlongPSig="1, 0.896" /label="S1068" promotor_-35 complement(2510476..2510483) /Source="Nicolas_upshift_promotors" /id="U2184" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=1875 /SigmaFactorBS="atacatatagaatgtgcaagtcagaaacacattgTTACCGTC tttttggaaagTATGGTAAAATGCAATACATactcgttcgtttcaagaatcattttct t" /listShort="S1067, clpX" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2510635) /Source="Nicolas_upshifts" /id="D1444" /incds=0 /nref=4 /ntot=16 /MaxReadThrough="8.26501" /MaxDrop="4.34985" /score="-0.284489083" /energy="-10.7" /TU="U2185,U2190" /idTUdmin="U2190" /TUdmin="-153" /isTUend="FALSE" /label="downshifts" CDS complement(2510639..2511913) /gene="tig" /locus_tag="BSU_28230" /old_locus_tag="BSU28230" /EC_number="5.2.1.8" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9748346, 12224648, 16156784, 17021213" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9748346, 12224648, 16156784, 17021213; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="prolyl isomerase (trigger factor)" /protein_id="NP_390701.1" /db_xref="EnsemblGenomes-Gn:BSU28230" /db_xref="EnsemblGenomes-Tr:CAB14783" /db_xref="GOA:P80698" /db_xref="InterPro:IPR001179" /db_xref="InterPro:IPR005215" /db_xref="InterPro:IPR008880" /db_xref="InterPro:IPR008881" /db_xref="InterPro:IPR027304" /db_xref="InterPro:IPR036611" /db_xref="SubtiList:BG19023" /db_xref="UniProtKB/Swiss-Prot:P80698" /translation="MSVKWEKQEGNEGVLTVEVDAETFKTALDDAFKKVVKQVSIPGF RKGKIPRGLFEQRFGVEALYQDALDILLPVEYPKAVEEAGIEPVDRPEIDVEKIEKGE SLIFTAKVTVKPEVKLGEYKGLGIEKDDTTVTDEDVQNELKALQERQAELVVKEEGAV EEGNTVVLDFEGFVDGEAFEGGKAENYSLEVGSGSFIPGFEDQLVGLEAGAEKDVEVT FPEEYHAEDLAGKPAVFKVKIHEIKAKELPELDDEFAKDIDEEVETLAELTEKTKKRL EEAKENEADAKLREELVLKASENAEIDVPQAMVDTELDRMLKEFEQRLQMQGMNLELY TQFSGQDEAALKEQMKEDAEKRVKSNLTLEAIAKAENLEVSDEEVDAELTKMAEAYNM PVENIKQAIGSTDAMKEDLKVRKAIDFLVENR*" /label="tig CDS" gene complement(2510639..2511913) /gene="tig" /locus_tag="BSU_28230" /old_locus_tag="BSU28230" /label="tig gene" S_feature complement(2511914..2512103) /Source="Nicolas_S_feature" /locus_tag="new_2887590_2887779_c" /HighExp="H2O2, HPh, BMM, dia15, T-4.40H, G180, Paraq, Oxctl, LBGexp, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigA, SigA" /TUlongPSig="1, 0.896" /label="S1069" promotor_-10 complement(2512090..2512109) /Source="Nicolas_upshift_promotors" /id="U2185" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.873126873126873" /psig=1 /xcortree=2561 /SigmaFactorBS="ttgaagaaatttcttatttgtaaatcgcgccatatAGTTGaa agcgctatgtgtTATGTTATAATATAGTGGTTgtatttgtgtataacgggttataaga a" /listShort="S1069, tig, S1068, S1067, clpX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2512103) /Source="Nicolas_upshifts" /id="U2185" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.873126873126873" /psig=1 /xcortree=2561 /SigmaFactorBS="ttgaagaaatttcttatttgtaaatcgcgccatatAGTTGaa agcgctatgtgtTATGTTATAATATAGTGGTTgtatttgtgtataacgggttataaga a" /listShort="S1069, tig, S1068, S1067, clpX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2512124..2512128) /Source="Nicolas_upshift_promotors" /id="U2185" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.873126873126873" /psig=1 /xcortree=2561 /SigmaFactorBS="ttgaagaaatttcttatttgtaaatcgcgccatatAGTTGaa agcgctatgtgtTATGTTATAATATAGTGGTTgtatttgtgtataacgggttataaga a" /listShort="S1069, tig, S1068, S1067, clpX" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2512141..2513145) /gene="ysoA" /locus_tag="BSU_28240" /old_locus_tag="BSU28240" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390702.2" /db_xref="EnsemblGenomes-Gn:BSU28240" /db_xref="EnsemblGenomes-Tr:CAB14784" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="SubtiList:BG12338" /db_xref="UniProtKB/Swiss-Prot:P94569" /translation="MTHDKKNAKIIPFPHLKDRLVEKGMSSLKEKKYQEALELFSEAM KYDDTESDLHLGMAICFLELGELEEAESVCEKMLKEGYGHYFTVLQVYMTILIQLKKY EEVKSTIEAVLEENQLPAESAEQFYKLLDFSRKMTDPDREDEAWAEEYEDTIDTEKVL ASPEEQMNLIHSLKDRNVAKYTGLLKTILQDPSAHPIIKTMIVMLLAEHEYSKPVHIS KFGESLTIEPSEIVPPDAAPILHRVLRVLDETLGNENPTLYAAVEELWRRHLYVLYPF QPKLLSADLWAAALHKVGYEMHGIEIESEELHMMYEFTDRELDEACTMLKDIEEISYL *" /label="ysoA CDS" gene complement(2512141..2513145) /gene="ysoA" /locus_tag="BSU_28240" /old_locus_tag="BSU28240" /label="ysoA gene" promotor_-10 complement(2513170..2513189) /Source="Nicolas_upshift_promotors" /id="U2186" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.609390609390609" /psig=1 /xcortree=1870 /SigmaFactorBS="ttgtccggcggctttttttgcctggtgaaacctttcatttCT TGTTTTtgttcacaggtGTTGATACACTTGAACAAAAtaaatgcctgaaaggaatata g" /listShort="ysoA" /listLong="S1069, tig, S1068, S1067, clpX" /label="promotor_-10" upshifts complement(2513188) /Source="Nicolas_upshifts" /id="U2186" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.609390609390609" /psig=1 /xcortree=1870 /SigmaFactorBS="ttgtccggcggctttttttgcctggtgaaacctttcatttCT TGTTTTtgttcacaggtGTTGATACACTTGAACAAAAtaaatgcctgaaaggaatata g" /listShort="ysoA" /listLong="S1069, tig, S1068, S1067, clpX" /label="upshifts" promotor_-35 complement(2513201..2513208) /Source="Nicolas_upshift_promotors" /id="U2186" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.609390609390609" /psig=1 /xcortree=1870 /SigmaFactorBS="ttgtccggcggctttttttgcctggtgaaacctttcatttCT TGTTTTtgttcacaggtGTTGATACACTTGAACAAAAtaaatgcctgaaaggaatata g" /listShort="ysoA" /listLong="S1069, tig, S1068, S1067, clpX" /label="promotor_-35" CDS complement(2513264..2513863) /gene="leuD" /locus_tag="BSU_28250" /old_locus_tag="BSU28250" /EC_number="4.2.1.33" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15228537, 15916605; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-isopropylmalate dehydratase (small subunit)" /protein_id="NP_390703.1" /db_xref="EnsemblGenomes-Gn:BSU28250" /db_xref="EnsemblGenomes-Tr:CAB14785" /db_xref="GOA:P94568" /db_xref="InterPro:IPR000573" /db_xref="InterPro:IPR004431" /db_xref="InterPro:IPR015928" /db_xref="InterPro:IPR033940" /db_xref="SubtiList:BG11950" /db_xref="UniProtKB/Swiss-Prot:P94568" /translation="MEPLKSHTGKAAVLNRINVDTDQIIPKQFLKRIERTGYGRFAFF DWRYDANGEPNPEFELNQPVYQGASILIAGENFGCGSSREHAPWALDDYGFKIIIAPS FADIFHQNCFKNGMLPIRMPYDNWKQLVGQYENQSLQMTVDLENQLIHDSEGNQISFE VDPHWKEMLINGYDEISLTLLLEDEIKQFESQRSSWLQA*" /label="leuD CDS" gene complement(2513264..2513863) /gene="leuD" /locus_tag="BSU_28250" /old_locus_tag="BSU28250" /label="leuD gene" downshifts complement(2513285) /Source="Nicolas_upshifts" /id="D1445" /incds=0 /nref=5 /ntot=111 /MaxReadThrough="6.76876" /MaxDrop="3.81278" /score="12.2084487" /energy="-9.9" /TU="U2190,U2191" /idTUdmin="U2186" /TUdmin="-1176" /isTUend="FALSE" /label="downshifts" CDS complement(2513876..2515294) /gene="leuC" /locus_tag="BSU_28260" /old_locus_tag="BSU28260" /EC_number="4.2.1.33" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15228537, 15916605; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-isopropylmalate dehydratase (large subunit)" /protein_id="NP_390704.1" /db_xref="EnsemblGenomes-Gn:BSU28260" /db_xref="EnsemblGenomes-Tr:CAB14786" /db_xref="GOA:P80858" /db_xref="InterPro:IPR001030" /db_xref="InterPro:IPR004430" /db_xref="InterPro:IPR015931" /db_xref="InterPro:IPR015932" /db_xref="InterPro:IPR018136" /db_xref="InterPro:IPR033941" /db_xref="InterPro:IPR036008" /db_xref="SubtiList:BG11949" /db_xref="UniProtKB/Swiss-Prot:P80858" /translation="MMPRTIIEKIWDQHIVKHGEGKPDLLYIDLHLIHEVTSPQAFEG LRQKGRKVRRPQNTFATMDHNIPTVNRFEIKDEVAKRQVTALERNCEEFGVRLADLHS VDQGIVHVVGPELGLTLPGKTIVCGDSHTSTHGAFGALAFGIGTSEVEHVLSTQTLWQ QRPKTLEVRVDGTLQKGVTAKDVILAVIGKYGVKFGTGYVIEYTGEVFRNMTMDERMT VCNMSIEAGARAGLIAPDEVTFEYCKNRKYTPKGEEFDKAVEEWKALRTDPGAVYDKS IVLDGNKISPMVTWGINPGMVLPVDSEVPAPESFSAEDDKKEAIRAYEYMGLTPHQKI EDIKVEHVFIGSCTNSRMTDLRQAADMIKGKKVADSVRAIVVPGSQSVKLQAEKEGLD QIFLEAGFEWRESGCSMCLSMNNDVVPEGERCASTSNRNFEGRQGKGARTHLVSPAMA AMAAIHGHFVDVRKFYQEKTVV*" /label="leuC CDS" gene complement(2513876..2515294) /gene="leuC" /locus_tag="BSU_28260" /old_locus_tag="BSU28260" /label="leuC gene" promotor_-35 2515183..2515187 /Source="Nicolas_upshift_promotors" /id="U2187" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.98901098901099" /psig="0.001998001998002" /xcortree=28 /SigmaFactorBS="ctttcttcccttttgtctcaagccttcaaatgcctgaggagA CGTCacctcatgaatgagGTGCAaatcaatatagagaagatccggctttccctcacca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2515202..2515206 /Source="Nicolas_upshift_promotors" /id="U2187" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.98901098901099" /psig="0.001998001998002" /xcortree=28 /SigmaFactorBS="ctttcttcccttttgtctcaagccttcaaatgcctgaggagA CGTCacctcatgaatgagGTGCAaatcaatatagagaagatccggctttccctcacca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2515202 /Source="Nicolas_upshifts" /id="U2187" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.98901098901099" /psig="0.001998001998002" /xcortree=28 /SigmaFactorBS="ctttcttcccttttgtctcaagccttcaaatgcctgaggagA CGTCacctcatgaatgagGTGCAaatcaatatagagaagatccggctttccctcacca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2515344..2516441) /gene="leuB" /locus_tag="BSU_28270" /old_locus_tag="BSU28270" /EC_number="1.1.1.85" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10095787, 15228537, 15916605, 17389690" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10095787, 15228537, 15916605, 17389690; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-isopropylmalate dehydrogenase" /protein_id="NP_390705.2" /db_xref="EnsemblGenomes-Gn:BSU28270" /db_xref="EnsemblGenomes-Tr:CAB14787" /db_xref="GOA:P05645" /db_xref="InterPro:IPR004429" /db_xref="InterPro:IPR019818" /db_xref="InterPro:IPR024084" /db_xref="SubtiList:BG10675" /db_xref="UniProtKB/Swiss-Prot:P05645" /translation="MKKRIALLPGDGIGPEVLESATDVLKSVAERFNHEFEFEYGLIG GAAIDEHHNPLPEETVAACKNADAILLGAVGGPKWDQNPSELRPEKGLLSIRKQLDLF ANLRPVKVFESLSDASPLKKEYIDNVDFVIVRELTGGLYFGQPSKRYVNTEGEQEAVD TLFYKRTEIERVIREGFKMAAARKGKVTSVDKANVLESSRLWREVAEDVAQEFPDVKL EHMLVDNAAMQLIYAPNQFDVVVTENMFGDILSDEASMLTGSLGMLPSASLSSSGLHL FEPVHGSAPDIAGKGMANPFAAILSAAMLLRTSFGLEEEAKAVEDAVNKVLASGKRTR DLARSEEFSSTQAITEEVKAAIMSENTISNV*" /label="leuB CDS" gene complement(2515344..2516441) /gene="leuB" /locus_tag="BSU_28270" /old_locus_tag="BSU28270" /label="leuB gene" CDS complement(2516462..2518018) /gene="leuA" /locus_tag="BSU_28280" /old_locus_tag="BSU28280" /EC_number="2.3.3.13" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15228537, 15916605, 16330546; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-isopropylmalate synthase" /protein_id="NP_390706.1" /db_xref="EnsemblGenomes-Gn:BSU28280" /db_xref="EnsemblGenomes-Tr:CAB14788" /db_xref="GOA:P94565" /db_xref="InterPro:IPR000891" /db_xref="InterPro:IPR002034" /db_xref="InterPro:IPR005671" /db_xref="InterPro:IPR013709" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR036230" /db_xref="SubtiList:BG11948" /db_xref="UniProtKB/Swiss-Prot:P94565" /translation="MRKINFFDTTLRDGEQSPGVNLNTQEKLAIAKQLERLGADIIEA GFPASSRGDFLAVQEIARTIKNCSVTGLARCVKGDIDAAWEALKDGAQPRIHVFIATS DIHLKHKLKMTREQVIERAVGMVKYAKERFPIVQWSAEDACRTELPFLAEIVEKVIDA GASVINLPDTVGYLAPAEYGNIFKYMKENVPNIHKAKLSAHCHDDLGMAVANSLAAIE NGADQIECAVNGIGERAGNAALEEIAVALHTRKDFYQVETGITLNEIKRTSDLVSKLT GMAVPRNKAVVGDNAFAHESGIHQDGFLKEKSTYEIISPELVGVTADALVLGKHSGRH AFKDRLTALGFQFDSEEINKFFTMFKELTEKKKEITDEDLVSLILEEKVTDRKIGYEF LSLQVHYGTSQVPTATLSLKNQENAQLIQEAATGAGSVEAIYNTLERCIDKDVELLDY RIQSNRKGEDAFAQVYVRVLVNGKESAGRGIAQDVLEASAKAYLNAVNRQLVFQSNMS GLKNHTAVGS*" /label="leuA CDS" gene complement(2516462..2518018) /gene="leuA" /locus_tag="BSU_28280" /old_locus_tag="BSU28280" /label="leuA gene" promotor_-35 2516858..2516861 /Source="Nicolas_upshift_promotors" /id="U2188" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.831168831168831" /psig=1 /xcortree=1529 /SigmaFactorBS="cttgttccgtaatgtacttgcagagaaagaaattcataccca atCTTGcgatctgttactttTTCTTCTAAAATAAGAGAAAcaagatcctcatcagtga t" /listShort="S1070" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2516874..2519315 /Source="Nicolas_S_feature" /locus_tag="new_2892550_2894991" /HighExp="Lbstat, C30, T0.30H, M9-stat, T1.30H, H2O2, M0t90, T2.0H, Salt, BC" /AntisenseName="ilvC" /AntisenseCor="-0.51305153097242795" /AntisenseRegPval="-18.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1070" upshifts 2516874 /Source="Nicolas_upshifts" /id="U2188" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.831168831168831" /psig=1 /xcortree=1529 /SigmaFactorBS="cttgttccgtaatgtacttgcagagaaagaaattcataccca atCTTGcgatctgttactttTTCTTCTAAAATAAGAGAAAcaagatcctcatcagtga t" /listShort="S1070" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2516876..2516895 /Source="Nicolas_upshift_promotors" /id="U2188" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.831168831168831" /psig=1 /xcortree=1529 /SigmaFactorBS="cttgttccgtaatgtacttgcagagaaagaaattcataccca atCTTGcgatctgttactttTTCTTCTAAAATAAGAGAAAcaagatcctcatcagtga t" /listShort="S1070" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2518005..2519033) /gene="ilvC" /locus_tag="BSU_28290" /old_locus_tag="BSU28290" /EC_number="1.1.1.86" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15228537, 15916605, 25393291, 25849365; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetohydroxy-acid isomeroreductase (NADP-dependent)" /protein_id="NP_390707.1" /db_xref="EnsemblGenomes-Gn:BSU28290" /db_xref="EnsemblGenomes-Tr:CAB14789" /db_xref="GOA:P37253" /db_xref="InterPro:IPR000506" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013023" /db_xref="InterPro:IPR013116" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR014359" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10672" /db_xref="UniProtKB/Swiss-Prot:P37253" /translation="MVKVYYNGDIKENVLAGKTVAVIGYGSQGHAHALNLKESGVDVI VGVRQGKSFTQAQEDGHKVFSVKEAAAQAEIIMVLLPDEQQQKVYEAEIKDELTAGKS LVFAHGFNVHFHQIVPPADVDVFLVAPKGPGHLVRRTYEQGAGVPALFAIYQDVTGEA RDKALAYAKGIGGARAGVLETTFKEETETDLFGEQAVLCGGLSALVKAGFETLTEAGY QPELAYFECLHELKLIVDLMYEEGLAGMRYSISDTAQWGDFVSGPRVVDAKVKESMKE VLKDIQNGTFAKEWIVENQVNRPRFNAINASENEHQIEVVGRKLREMMPFVKQGKKKE AVVSVAQN*" /label="ilvC CDS" gene complement(2518005..2519033) /gene="ilvC" /locus_tag="BSU_28290" /old_locus_tag="BSU28290" /label="ilvC gene" CDS complement(2519057..2519575) /gene="ilvH" /locus_tag="BSU_28300" /old_locus_tag="BSU28300" /EC_number="2.2.1.6" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 10229948, 14702326, 15228537, 15916605; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetohydroxy-acid synthase (small subunit)" /protein_id="NP_390708.2" /db_xref="EnsemblGenomes-Gn:BSU28300" /db_xref="EnsemblGenomes-Tr:CAB14790" /db_xref="GOA:P37252" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR004789" /db_xref="InterPro:IPR019455" /db_xref="SubtiList:BG10671" /db_xref="UniProtKB/Swiss-Prot:P37252" /translation="MKRIITLTVVNRSGVLNRITGLFTKRHYNIESITVGHTETAGVS RITFVVHVEGENDVEQLTKQLNKQIDVLKVTDITNQSIVQRELALIKVVSAPSTRTEI NGIIEPFRASVVDVSRDSIVVQVTGESNKIEALIELLKPYGIKEIARTGTTAFARGTQ QKASSNKTISIV*" /label="ilvH CDS" gene complement(2519057..2519575) /gene="ilvH" /locus_tag="BSU_28300" /old_locus_tag="BSU28300" /label="ilvH gene" promotor_-35 2519296..2519299 /Source="Nicolas_upshift_promotors" /id="U2189" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.947052947052947" /psig="0.041958041958042" /xcortree=26 /SigmaFactorBS="ctatgattccattaatctctgttcttgttgaaggtgcggAGA CaaccttgattaaggcCAGCTccctctggacaatcgattgatttgtgatgtctgtgac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2519315..2519319 /Source="Nicolas_upshift_promotors" /id="U2189" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.947052947052947" /psig="0.041958041958042" /xcortree=26 /SigmaFactorBS="ctatgattccattaatctctgttcttgttgaaggtgcggAGA CaaccttgattaaggcCAGCTccctctggacaatcgattgatttgtgatgtctgtgac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2519317 /Source="Nicolas_upshifts" /id="U2189" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.947052947052947" /psig="0.041958041958042" /xcortree=26 /SigmaFactorBS="ctatgattccattaatctctgttcttgttgaaggtgcggAGA CaaccttgattaaggcCAGCTccctctggacaatcgattgatttgtgatgtctgtgac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2519572..2521296) /gene="ilvB" /locus_tag="BSU_28310" /old_locus_tag="BSU28310" /EC_number="2.2.1.6" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 10229948, 14702326, 15228537, 15916605; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetohydroxy-acid synthase (large subunit)" /protein_id="NP_390709.1" /db_xref="EnsemblGenomes-Gn:BSU28310" /db_xref="EnsemblGenomes-Tr:CAB14791" /db_xref="GOA:P37251" /db_xref="InterPro:IPR011766" /db_xref="InterPro:IPR012000" /db_xref="InterPro:IPR012001" /db_xref="InterPro:IPR012846" /db_xref="InterPro:IPR029035" /db_xref="InterPro:IPR029061" /db_xref="SubtiList:BG10670" /db_xref="UniProtKB/Swiss-Prot:P37251" /translation="MGTNVQVDSASAECTQTMSGALMLIESLKKEKVEMIFGYPGGAV LPIYDKLYNSGLVHILPRHEQGAIHAAEGYARVSGKPGVVIATSGPGATNLVTGLADA MIDSLPLVVFTGQVATSVIGSDAFQEADILGITMPVTKHSYQVRQPEDLPRIIKEAFH IATTGRPGPVLIDIPKDVATIEGEFSYDHEMNLPGYQPTTEPNYLQIRKLVEAVSSAK KPVILAGAGVLHGKASEELKNYAEQQQIPVAHTLLGLGGFPADHPLFLGMAGMHGTYT ANMALHECDLLISIGARFDDRVTGNLKHFARNAKIAHIDIDPAEIGKIMKTQIPVVGD SKIVLQELIKQDGKQSDSSEWKKQLAEWKEEYPLWYVDNEEEGFKPQKLIEYIHQFTK GEAIVATDVGQHQMWSAQFYPFQKADKWVTSGGLGTMGFGLPAAIGAQLAEKDATVVA VVGDGGFQMTLQELDVIRELNLPVKVVILNNACLGMVRQWQEIFYEERYSESKFASQP DFVKLSEAYGIKGIRISSEAEAKEKLEEALTSREPVVIDVRVASEEKVFPMVAPGKGL HEMVGVKP*" /label="ilvB CDS" gene complement(2519572..2521296) /gene="ilvB" /locus_tag="BSU_28310" /old_locus_tag="BSU28310" /label="ilvB gene" S_feature complement(2521297..2521417) /Source="Nicolas_S_feature" /locus_tag="new_2896973_2897093_c" /HighExp="T-5.40H, T-4.40H, S2, MG 120, Glucon, GM-0.2, T-2.40H, GM-0.1, HiOs, T-3.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 0.896" /TUlongSig="NA" /TUlongPSig="NA" /label="S1071" misc_RNA complement(2521418..2521664) /gene="tboILV" /locus_tag="BSU_misc_RNA_45" /product="T-box controlling synthesis of branched chain amino acids" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 1317842, 9098041, 12165569, 12547201; Product type n: RNA" /function="16.3: Control" /label="tboILV RNA" gene complement(2521418..2521664) /gene="tboILV" /locus_tag="BSU_misc_RNA_45" /label="tboILV gene" downshifts complement(2521461) /Source="Nicolas_upshifts" /id="D1446" /incds=0 /nref=18 /ntot=78 /MaxReadThrough="7.67475" /MaxDrop="4.2339" /score="5.33237345" /energy="-13.8" /TU="U2190,U2191" /idTUdmin="U2195" /TUdmin=2682 /isTUend="FALSE" /label="downshifts" S_feature complement(2521665..2521791) /Source="Nicolas_S_feature" /locus_tag="new_2897341_2897467_c" /HighExp="LoTm, HiOs, T-3.40H, BC, B60, Pyr, GM 15, T-5.40H, UNK1, MG 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 0.896" /TUlongSig="NA" /TUlongPSig="NA" /label="S1072" promotor_-10 complement(2521773..2521792) /Source="Nicolas_upshift_promotors" /id="U2190" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.867132867132867" /psig="0.998001998001998" /xcortree=2905 /SigmaFactorBS="tgattaatcaaaattgtctaataattttaaaaaatgcTGTTG ACActgcgtccaaagcgGCGTAATATGAGTTCAACAAaagataaatgcaagcttcaca a" /listShort="S1072, NA, S1071, ilvB, ilvH, ilvC, leuA, leuB, leuC, leuD, ysoA, S1069, tig, S1068" /listLong="S1067, clpX" /label="promotor_-10" upshifts complement(2521791) /Source="Nicolas_upshifts" /id="U2190" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.867132867132867" /psig="0.998001998001998" /xcortree=2905 /SigmaFactorBS="tgattaatcaaaattgtctaataattttaaaaaatgcTGTTG ACActgcgtccaaagcgGCGTAATATGAGTTCAACAAaagataaatgcaagcttcaca a" /listShort="S1072, NA, S1071, ilvB, ilvH, ilvC, leuA, leuB, leuC, leuD, ysoA, S1069, tig, S1068" /listLong="S1067, clpX" /label="upshifts" S_feature complement(2521793..2521923) /Source="Nicolas_S_feature" /locus_tag="new_2897469_2897599_c" /HighExp="Cold, S8, S0, S7, Mal, S6, G135, M9-stat, C30, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.896" /TUlongSig="NA" /TUlongPSig="NA" /label="S1073" promotor_-35 complement(2521807..2521814) /Source="Nicolas_upshift_promotors" /id="U2190" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.867132867132867" /psig="0.998001998001998" /xcortree=2905 /SigmaFactorBS="tgattaatcaaaattgtctaataattttaaaaaatgcTGTTG ACActgcgtccaaagcgGCGTAATATGAGTTCAACAAaagataaatgcaagcttcaca a" /listShort="S1072, NA, S1071, ilvB, ilvH, ilvC, leuA, leuB, leuC, leuD, ysoA, S1069, tig, S1068" /listLong="S1067, clpX" /label="promotor_-35" promotor_-10 complement(2521918..2521937) /Source="Nicolas_upshift_promotors" /id="U2191" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.747252747252747" /psig="0.896103896103896" /xcortree=310 /SigmaFactorBS="tgttataaaatcttccatgtttatataaaattaAATAattct ggtgtattCTTGATAGATTAATAAAAAAattataaaaacttttaacatttgcaattcc t" /listShort="S1073, S1072, NA, S1071, ilvB, ilvH, ilvC, leuA, leuB, leuC, leuD, ysoA" /listLong="S1069, tig, S1068, S1067, clpX" /label="promotor_-10" upshifts complement(2521927) /Source="Nicolas_upshifts" /id="U2191" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.747252747252747" /psig="0.896103896103896" /xcortree=310 /SigmaFactorBS="tgttataaaatcttccatgtttatataaaattaAATAattct ggtgtattCTTGATAGATTAATAAAAAAattataaaaacttttaacatttgcaattcc t" /listShort="S1073, S1072, NA, S1071, ilvB, ilvH, ilvC, leuA, leuB, leuC, leuD, ysoA" /listLong="S1069, tig, S1068, S1067, clpX" /label="upshifts" promotor_-35 complement(2521951..2521954) /Source="Nicolas_upshift_promotors" /id="U2191" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.747252747252747" /psig="0.896103896103896" /xcortree=310 /SigmaFactorBS="tgttataaaatcttccatgtttatataaaattaAATAattct ggtgtattCTTGATAGATTAATAAAAAAattataaaaacttttaacatttgcaattcc t" /listShort="S1073, S1072, NA, S1071, ilvB, ilvH, ilvC, leuA, leuB, leuC, leuD, ysoA" /listLong="S1069, tig, S1068, S1067, clpX" /label="promotor_-35" promotor_-35 2522049..2522058 /Source="Nicolas_upshift_promotors" /id="U2192" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1322 /SigmaFactorBS="ctgacagatcatcttgcaatccatttcaatttcggATAGGCA CTTctcttgttccctcGGCATACATTAATGATATCTtgcaaagaaaaggtgatacgat g" /listShort="ysnD, S1074, ysnE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2522072..2522091 /Source="Nicolas_upshift_promotors" /id="U2192" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1322 /SigmaFactorBS="ctgacagatcatcttgcaatccatttcaatttcggATAGGCA CTTctcttgttccctcGGCATACATTAATGATATCTtgcaaagaaaaggtgatacgat g" /listShort="ysnD, S1074, ysnE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2522074 /Source="Nicolas_upshifts" /id="U2192" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1322 /SigmaFactorBS="ctgacagatcatcttgcaatccatttcaatttcggATAGGCA CTTctcttgttccctcGGCATACATTAATGATATCTtgcaaagaaaaggtgatacgat g" /listShort="ysnD, S1074, ysnE" /GFF_Attribute="listLong" /label="upshifts" CDS 2522112..2522447 /gene="cotQ" /locus_tag="BSU_28320" /old_locus_tag="BSU28320" /experiment="publication(s) with functional evidences, PMID:19933362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19933362; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="inner spore coat protein" /protein_id="NP_390710.1" /db_xref="EnsemblGenomes-Gn:BSU28320" /db_xref="EnsemblGenomes-Tr:CAB14792" /db_xref="SubtiList:BG12335" /db_xref="UniProtKB/Swiss-Prot:P94563" /translation="MNKSFADMQGFPAGFPSFPNFPQQYYPAVPPFYQQSQQPFGGYG YGQPFSQAYSPLTTPSGMYSSFPYASGFYGQQFSGAGFSGHGGSLSAPAIHAGGFSGA PGVHGGFRY*" /label="cotQ CDS" gene 2522112..2522447 /gene="cotQ" /locus_tag="BSU_28320" /old_locus_tag="BSU28320" /label="cotQ gene" downshifts 2522441 /Source="Nicolas_upshifts" /id="D1447" /incds=0 /nref=14 /ntot=36 /MaxReadThrough="3.79194" /MaxDrop="6.48183" /score="11.836855" /energy="-13" /TU="U2192" /idTUdmin="U2193" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" promotor_-35 2522528..2522535 /Source="Nicolas_upshift_promotors" /id="U2193" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.486513486513487" /psig="0.954045954045954" /xcortree=614 /SigmaFactorBS="ttttaaaacgacttcacaagtacagtcacattttctgTCTTT ATAtttggaaacaggaTGGAATATGATTAAGATGAAttgaacgatattctgcacaatc c" /listShort="S1074" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2522549..2522568 /Source="Nicolas_upshift_promotors" /id="U2193" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.486513486513487" /psig="0.954045954045954" /xcortree=614 /SigmaFactorBS="ttttaaaacgacttcacaagtacagtcacattttctgTCTTT ATAtttggaaacaggaTGGAATATGATTAAGATGAAttgaacgatattctgcacaatc c" /listShort="S1074" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2522551..2522615 /Source="Nicolas_S_feature" /locus_tag="new_2898227_2898291" /HighExp="S5, S6, S8, S7, B36, S4, S3, B60, BT, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.954, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1074" upshifts 2522551 /Source="Nicolas_upshifts" /id="U2193" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.486513486513487" /psig="0.954045954045954" /xcortree=614 /SigmaFactorBS="ttttaaaacgacttcacaagtacagtcacattttctgTCTTT ATAtttggaaacaggaTGGAATATGATTAAGATGAAttgaacgatattctgcacaatc c" /listShort="S1074" /GFF_Attribute="listLong" /label="upshifts" CDS 2522616..2523071 /gene="ysnE" /locus_tag="BSU_28330" /old_locus_tag="BSU28330" /EC_number="2.3.1.-" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17555270, 26337367; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative indole acetic acid N-acetyltransferase" /protein_id="NP_390711.1" /db_xref="EnsemblGenomes-Gn:BSU28330" /db_xref="EnsemblGenomes-Tr:CAB14793" /db_xref="GOA:P94562" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="PDB:1YX0" /db_xref="SubtiList:BG12336" /db_xref="UniProtKB/Swiss-Prot:P94562" /translation="MHIKIDDLTGRQVVSLVNEHLHSMTLMSPPESIHALGLEKLRGP EITFWSAWEGDELAGCGALKELDTRHGEIKSMRTSASHLRKGVAKQVLQHIIEEAEKR GYERLSLETGSMASFEPARKLYESFGFQYCEPFADYGEDPNSVFMTKKL*" /label="ysnE CDS" gene 2522616..2523071 /gene="ysnE" /locus_tag="BSU_28330" /old_locus_tag="BSU28330" /label="ysnE gene" promotor_-35 2523179..2523185 /Source="Nicolas_upshift_promotors" /id="U2194" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=194 /SigmaFactorBS="cacctttatgatacacgccaatgttttcaatttTGTTTAAtt caaagaacagcGGGAATTACAAACGACATGaacgatatcatgcaaattcataaaggag g" /listShort="ysnF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2523199..2523217 /Source="Nicolas_upshift_promotors" /id="U2194" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=194 /SigmaFactorBS="cacctttatgatacacgccaatgttttcaatttTGTTTAAtt caaagaacagcGGGAATTACAAACGACATGaacgatatcatgcaaattcataaaggag g" /listShort="ysnF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2523206 /Source="Nicolas_upshifts" /id="U2194" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=194 /SigmaFactorBS="cacctttatgatacacgccaatgttttcaatttTGTTTAAtt caaagaacagcGGGAATTACAAACGACATGaacgatatcatgcaaattcataaaggag g" /listShort="ysnF" /GFF_Attribute="listLong" /label="upshifts" CDS 2523255..2524076 /gene="ysnF" /locus_tag="BSU_28340" /old_locus_tag="BSU28340" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11988534, 27464829; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="putative stress response protein" /protein_id="NP_390712.3" /db_xref="EnsemblGenomes-Gn:BSU28340" /db_xref="EnsemblGenomes-Tr:CAB14794" /db_xref="InterPro:IPR019060" /db_xref="InterPro:IPR025889" /db_xref="SubtiList:BG12337" /db_xref="UniProtKB/Swiss-Prot:P94560" /translation="MKSIVGVYETPQETIAAIEGLLTKGYDSDDISVVTSRRDTDYLE SRTGTEVNQAIDAHQDESESFFDKLKDYFTMDDTATHSKALSDLDIKTDEIDKYQEDL DDGKLLVAVDTDADVIAPIDNGNALSGGFSSTNELDYTTKEEKTMPLREEQLKVDKED VQTGEVEIGKEVKTEKRDMDIPVRHDEIYVERRPVDENKTDAAPVNDSEEIRVPIVEE KLEVTKKPVVTDEVVVGKRTVEENEHISETVKKEEPRLNKEGKVDGLDDDPLNNK*" /label="ysnF CDS" gene 2523255..2524076 /gene="ysnF" /locus_tag="BSU_28340" /old_locus_tag="BSU28340" /label="ysnF gene" downshifts 2524069 /Source="Nicolas_upshifts" /id="D1448" /incds=0 /nref=8 /ntot=77 /MaxReadThrough="2.49244" /MaxDrop="8.12771" /score="22.7277041" /energy="-13.3" /TU="NA" /idTUdmin="U2194" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" downshifts 2524133 /Source="Nicolas_upshifts" /id="D1449" /incds=0 /nref=1 /ntot=38 /MaxReadThrough="1.26489" /MaxDrop="4.30778" /score="22.7277041" /energy="-13.3" /TU="NA" /idTUdmin="U2194" /TUdmin=43 /isTUend="FALSE" /label="downshifts" tRNA complement(2524140..2524213) /gene="trnSL-Arg2" /locus_tag="BSU_tRNA_84" /product="tRNA-Arg" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Arg (UCU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Arg2 tRNA" gene complement(2524140..2524213) /gene="trnSL-Arg2" /locus_tag="BSU_tRNA_84" /label="trnSL-Arg2 gene" downshifts complement(2524174) /Source="Nicolas_upshifts" /id="D1450" /incds=0 /nref=34 /ntot=243 /MaxReadThrough="1.54905" /MaxDrop="4.72186" /score="24.0242272" /energy="-13.3" /TU="U2195,U2196" /idTUdmin="U2195" /TUdmin="-31" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2524250..2524269) /Source="Nicolas_upshift_promotors" /id="U2195" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.843156843156843" /psig=1 /xcortree=282 /SigmaFactorBS="catgaaaaaaattctaaaaaaccGTTGACTTattattgcatc ccATATATAATAAATCTTGTCGctgatagttaaagcgaaaaacaaaaaaacaaaacgt g" /listShort="trnSL-Arg2" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2524253) /Source="Nicolas_upshifts" /id="U2195" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.843156843156843" /psig=1 /xcortree=282 /SigmaFactorBS="catgaaaaaaattctaaaaaaccGTTGACTTattattgcatc ccATATATAATAAATCTTGTCGctgatagttaaagcgaaaaacaaaaaaacaaaacgt g" /listShort="trnSL-Arg2" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2524283..2524290) /Source="Nicolas_upshift_promotors" /id="U2195" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.843156843156843" /psig=1 /xcortree=282 /SigmaFactorBS="catgaaaaaaattctaaaaaaccGTTGACTTattattgcatc ccATATATAATAAATCTTGTCGctgatagttaaagcgaaaaacaaaaaaacaaaacgt g" /listShort="trnSL-Arg2" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2524344..2524853) /gene="ysnB" /locus_tag="BSU_28350" /old_locus_tag="BSU28350" /EC_number="3.1.4.-" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphoesterase" /protein_id="NP_390713.2" /db_xref="EnsemblGenomes-Gn:BSU28350" /db_xref="EnsemblGenomes-Tr:CAB14795" /db_xref="GOA:P94559" /db_xref="InterPro:IPR000979" /db_xref="InterPro:IPR020935" /db_xref="InterPro:IPR024654" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG12334" /db_xref="UniProtKB/Swiss-Prot:P94559" /translation="MNVLIISDSHGLEEELQTIAKRHEAEVDLMIHCGDSELETRHPA LEPYAVVKGNCDFAGDFKDELLLTAGSRKILVTHGHLHGIKQTLLNVYYRAEELGADV ICFGHSHIAGSEVLRGKLMINPGSIRLPRVRRTESYAILTLENDAATVRFYDQAGNEI EDLQNRVTL*" /label="ysnB CDS" gene complement(2524344..2524853) /gene="ysnB" /locus_tag="BSU_28350" /old_locus_tag="BSU28350" /label="ysnB gene" downshifts complement(2524361) /Source="Nicolas_upshifts" /id="D1451" /incds=0 /nref=87 /ntot=225 /MaxReadThrough="4.15666" /MaxDrop="5.59323" /score="24.0242272" /energy="-13.3" /TU="U2196,U2197" /idTUdmin="U2197" /TUdmin="-130" /isTUend="FALSE" /label="downshifts" CDS complement(2524869..2525465) /gene="rdgB" /locus_tag="BSU_28360" /old_locus_tag="BSU28360" /EC_number="3.6.1.66" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16322510, 17090528, 17976651, 18689515, 19943897; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="deoxyinosine/deoxyxanthosine triphosphate pyrophosphatase, promiscuous (subunit A)" /protein_id="NP_390714.1" /db_xref="EnsemblGenomes-Gn:BSU28360" /db_xref="EnsemblGenomes-Tr:CAB14796" /db_xref="GOA:P94558" /db_xref="InterPro:IPR002637" /db_xref="InterPro:IPR020922" /db_xref="InterPro:IPR029001" /db_xref="SubtiList:BG12333" /db_xref="UniProtKB/Swiss-Prot:P94558" /translation="MIIMKEAIIATHNPGKVKEFKEILEPRGYDVKSLAEIGFTEEIE ETGHTFEENAIMKAEAVAKAVNKMVIADDSGLSIDNLGGRPGVYSARYAGEQKDDQAN IEKVLSELKGIEKEQRTARFRCALAVSIPGEETKTVEGHVEGYIAEEPRGEYGFGYDP IFIVKDKDKTMAELTSDEKNKISHRADALKKLSKLLEA*" /label="rdgB CDS" gene complement(2524869..2525465) /gene="rdgB" /locus_tag="BSU_28360" /old_locus_tag="BSU28360" /label="rdgB gene" CDS complement(2525478..2526215) /gene="rph" /locus_tag="BSU_28370" /old_locus_tag="BSU28370" /EC_number="2.7.7.56" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:1624460, 19153445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1624460, 19153445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease PH" /protein_id="NP_390715.1" /db_xref="EnsemblGenomes-Gn:BSU28370" /db_xref="EnsemblGenomes-Tr:CAB14797" /db_xref="GOA:P28619" /db_xref="InterPro:IPR001247" /db_xref="InterPro:IPR002381" /db_xref="InterPro:IPR015847" /db_xref="InterPro:IPR018336" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR027408" /db_xref="InterPro:IPR036345" /db_xref="PDB:1OYP" /db_xref="PDB:1OYR" /db_xref="PDB:1OYS" /db_xref="SubtiList:BG10357" /db_xref="UniProtKB/Swiss-Prot:P28619" /translation="MRHDGRQHDELRPITFDLDFISHPEGSVLITAGNTKVICNASVE DRVPPFLRGGGKGWITAEYSMLPRATNQRTIRESSKGKISGRTMEIQRLIGRALRAVV DLEKLGERTIWIDCDVIQADGGTRTASITGAFLAMAIAIGKLIKAGTIKTNPITDFLA AISVGIDKEQGILLDLNYEEDSSAEVDMNVIMTGSGRFVELQGTGEEATFSREDLNGL LGLAEKGIQELIDKQKEVLGDSLPELK*" /label="rph CDS" gene complement(2525478..2526215) /gene="rph" /locus_tag="BSU_28370" /old_locus_tag="BSU28370" /label="rph gene" promotor_-10 complement(2526297..2526316) /Source="Nicolas_upshift_promotors" /id="U2196" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.502497502497502" /psig="0.947052947052947" /xcortree=1453 /SigmaFactorBS="acagaaccggtctccagaccatctcaagtgaatacggGTAGT TtttaaattgggattTTTGATATACTAGGAAGAAAgaggttagcgttccggctgcctc t" /listShort="rph, ysnA, ysnB, trnSL-Arg2" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2526313) /Source="Nicolas_upshifts" /id="U2196" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.502497502497502" /psig="0.947052947052947" /xcortree=1453 /SigmaFactorBS="acagaaccggtctccagaccatctcaagtgaatacggGTAGT TtttaaattgggattTTTGATATACTAGGAAGAAAgaggttagcgttccggctgcctc t" /listShort="rph, ysnA, ysnB, trnSL-Arg2" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2526326..2527426) /gene="gerM" /locus_tag="BSU_28380" /old_locus_tag="BSU28380" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:14662349, 27381174" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14662349, 27381174; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="germination (cortex hydrolysis) and sporulation (stage II, multiple polar septa) lytic enzyme" /protein_id="NP_390716.1" /db_xref="EnsemblGenomes-Gn:BSU28380" /db_xref="EnsemblGenomes-Tr:CAB14798" /db_xref="GOA:P39072" /db_xref="InterPro:IPR019606" /db_xref="SubtiList:BG10356" /db_xref="UniProtKB/Swiss-Prot:P39072" /translation="MLKKGPAVIGATCLTSALLLSGCGLFQSDKAAEEIDPPQDVTFV NDEAGANSNTTAAKKTESEKSDTAKADQASSTVMRELYLIDKNGYVVAQTLPLPKSES TAKQALEYLVQGGPVSEILPNGFRAVLPADTTVNVDIKKDGTAIADFSNEFKNYKKED EQKIVQSVTWTLTQFSSIDKVKLRINGHELKEMPVGGTPISDDLSRKDGINLETAGVN DLTATHPLTVYYLAENEDSEYYVPVTKRIDNSEKDDITAAINELAKGPSKVSGLLTDF SEDVKLVSKPKIKDGRVTLDFNQSIFGSADEKTKMISSEVLNSIVLTLTEQPDVKSVS VKVNGKSELVNEKGEKLTEPVSRPSQVNTGSF*" /label="gerM CDS" gene complement(2526326..2527426) /gene="gerM" /locus_tag="BSU_28380" /old_locus_tag="BSU28380" /label="gerM gene" promotor_-35 complement(2526331..2526336) /Source="Nicolas_upshift_promotors" /id="U2196" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.502497502497502" /psig="0.947052947052947" /xcortree=1453 /SigmaFactorBS="acagaaccggtctccagaccatctcaagtgaatacggGTAGT TtttaaattgggattTTTGATATACTAGGAAGAAAgaggttagcgttccggctgcctc t" /listShort="rph, ysnA, ysnB, trnSL-Arg2" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2526343) /Source="Nicolas_upshifts" /id="D1452" /incds=0 /nref=2 /ntot=16 /MaxReadThrough="5.80816" /MaxDrop="4.3535" /score="41.5916163" /energy="-13" /TU="U2197" /idTUdmin="U2198" /TUdmin=1209 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2527449..2527467) /Source="Nicolas_upshift_promotors" /id="U2197" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=980 /SigmaFactorBS="tatgttgcgggtttttttctgttttgccggaattcttcGGTC TAtttcctaaagaggcTCGTATACATAATAGTACAaacatccttaggagggaaaagta t" /listShort="gerM, rph, ysnA, ysnB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2527465) /Source="Nicolas_upshifts" /id="U2197" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=980 /SigmaFactorBS="tatgttgcgggtttttttctgttttgccggaattcttcGGTC TAtttcctaaagaggcTCGTATACATAATAGTACAaacatccttaggagggaaaagta t" /listShort="gerM, rph, ysnA, ysnB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2527482..2527487) /Source="Nicolas_upshift_promotors" /id="U2197" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=980 /SigmaFactorBS="tatgttgcgggtttttttctgttttgccggaattcttcGGTC TAtttcctaaagaggcTCGTATACATAATAGTACAaacatccttaggagggaaaagta t" /listShort="gerM, rph, ysnA, ysnB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2527541..2528359) /gene="rcmE" /locus_tag="BSU_28390" /old_locus_tag="BSU28390" /EC_number="5.1.1.3" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 15347750, 17610893, 17720142, 19309142; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate racemase" /protein_id="NP_390717.2" /db_xref="EnsemblGenomes-Gn:BSU28390" /db_xref="EnsemblGenomes-Tr:CAB14799" /db_xref="GOA:P94556" /db_xref="InterPro:IPR001920" /db_xref="InterPro:IPR004391" /db_xref="InterPro:IPR015942" /db_xref="InterPro:IPR018187" /db_xref="InterPro:IPR033134" /db_xref="PDB:1ZUW" /db_xref="SubtiList:BG11964" /db_xref="UniProtKB/Swiss-Prot:P94556" /translation="MLEQPIGVIDSGVGGLTVAKEIMRQLPKENIIYVGDTKRCPYGP RPEEEVLQYTWELTNYLLENHHIKMLVIACNTATAIALDDIQRSVGIPVVGVIQPGAR AAIKVTDNQHIGVIGTENTIKSNAYEEALLALNPDLKVENLACPLLVPFVESGKFLDK TADEIVKTSLYPLKDTSIDSLILGCTHYPILKEAIQRYMGEHVNIISSGDETAREVST ILSYKGLLNQSPIAPDHQFLTTGARDQFAKIADDWFGHEVGHVECISLQEPIKR*" /label="rcmE CDS" gene complement(2527541..2528359) /gene="rcmE" /locus_tag="BSU_28390" /old_locus_tag="BSU28390" /label="rcmE gene" downshifts complement(2527553) /Source="Nicolas_upshifts" /id="D1453" /incds=0 /nref=230 /ntot=265 /MaxReadThrough="0.9265" /MaxDrop="6.72492" /score="41.5916163" /energy="-13" /TU="NA" /idTUdmin="U2198" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2528367..2528807) /gene="ysmB" /locus_tag="BSU_28400" /old_locus_tag="BSU28400" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26577401; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (mother cell's gene expression during sporulation)" /protein_id="NP_390718.1" /db_xref="EnsemblGenomes-Gn:BSU28400" /db_xref="EnsemblGenomes-Tr:CAB14800" /db_xref="GOA:P97247" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12332" /db_xref="UniProtKB/Swiss-Prot:P97247" /translation="MTSKPLEHVADIEKSLRHIAAIIKQKGREILNQYAITPPQFVGL QWLYELGDMTIGELSGKMYLACSTTTDLIDRMQKNELVERVKDPADRRVVRIHLLPEG ERIIQEVITKRQEYLRDMFESFTDEEIAIFEKSLMKLQHEMKRK*" /label="ysmB CDS" gene complement(2528367..2528807) /gene="ysmB" /locus_tag="BSU_28400" /old_locus_tag="BSU28400" /label="ysmB gene" promotor_-10 complement(2528850..2528869) /Source="Nicolas_upshift_promotors" /id="U2198" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.862137862137862" /psig="0.997002997002997" /xcortree=2513 /SigmaFactorBS="gactaaagtcctctatttctctcctgcgagTCTTGcattttc ttcaaaaaAGAAGGAAAATAGACACGGAacgcttttgtgcgtaagagatccttgagtg a" /listShort="ysmB, racE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2528859) /Source="Nicolas_upshifts" /id="U2198" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.862137862137862" /psig="0.997002997002997" /xcortree=2513 /SigmaFactorBS="gactaaagtcctctatttctctcctgcgagTCTTGcattttc ttcaaaaaAGAAGGAAAATAGACACGGAacgcttttgtgcgtaagagatccttgagtg a" /listShort="ysmB, racE" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2528861..2529003) /Source="Nicolas_S_feature" /locus_tag="new_2904537_2904679_c" /HighExp="BT, B36, S6, S8, S7, B60, Pyr, G/S, Lbtran, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.121047" /TUshortSig="SigK, SigA" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1075" promotor_-35 complement(2528885..2528889) /Source="Nicolas_upshift_promotors" /id="U2198" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.862137862137862" /psig="0.997002997002997" /xcortree=2513 /SigmaFactorBS="gactaaagtcctctatttctctcctgcgagTCTTGcattttc ttcaaaaaAGAAGGAAAATAGACACGGAacgcttttgtgcgtaagagatccttgagtg a" /listShort="ysmB, racE" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2529048) /Source="Nicolas_upshifts" /id="D1454" /incds=0 /nref=2 /ntot=16 /MaxReadThrough="6.16749" /MaxDrop="4.6532" /score="20.9204638" /energy="-10.8" /TU="U2200,U2202" /idTUdmin="U2202" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" CDS complement(2529051..2529275) /gene="gerE" /locus_tag="BSU_28410" /old_locus_tag="BSU28410" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11243786, 11418558, 11741866, 14702409, 17172339, 20435725, 21670523, 26790838" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11243786, 11418558, 11741866, 14702409, 17172339, 20435725, 21670523, 26790838; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="transcriptional regulator required for the expression of late spore coat genes" /protein_id="NP_390719.2" /db_xref="EnsemblGenomes-Gn:BSU28410" /db_xref="EnsemblGenomes-Tr:CAB14801" /db_xref="GOA:P11470" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="PDB:1FSE" /db_xref="SubtiList:BG10355" /db_xref="UniProtKB/Swiss-Prot:P11470" /translation="MKEKEFQSKPLLTKREREVFELLVQDKTTKEIASELFISEKTVR NHISNAMQKLGVKGRSQAVVELLRMGELEL*" /label="gerE CDS" gene complement(2529051..2529275) /gene="gerE" /locus_tag="BSU_28410" /old_locus_tag="BSU28410" /label="gerE gene" upshifts 2529324 /Source="Nicolas_upshifts" /id="U2199" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.481518481518482" /psig="0.838161838161838" /xcortree=697 /SigmaFactorBS="tttctccttcaagtattgtaaccctccttgctaaggtgagag cgaatcagaaacgaatgggtTTTGATATAGTCGAGATATcatatgtaagaagggcgca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 2529326..2529344 /Source="Nicolas_upshift_promotors" /id="U2199" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.481518481518482" /psig="0.838161838161838" /xcortree=697 /SigmaFactorBS="tttctccttcaagtattgtaaccctccttgctaaggtgagag cgaatcagaaacgaatgggtTTTGATATAGTCGAGATATcatatgtaagaagggcgca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(2529333..2529352) /Source="Nicolas_upshift_promotors" /id="U2200" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1352 /SigmaFactorBS="aaacgcttcttcatacacgataaactaattatcttgtaAACG TCACCTcctgcgcccttctTACATATGATATCTCGACTAtatcaaaacccattcgttt c" /listShort="gerE, S1075, ysmB, racE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2529353) /Source="Nicolas_upshifts" /id="U2200" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1352 /SigmaFactorBS="aaacgcttcttcatacacgataaactaattatcttgtaAACG TCACCTcctgcgcccttctTACATATGATATCTCGACTAtatcaaaacccattcgttt c" /listShort="gerE, S1075, ysmB, racE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2529366..2529375) /Source="Nicolas_upshift_promotors" /id="U2200" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1352 /SigmaFactorBS="aaacgcttcttcatacacgataaactaattatcttgtaAACG TCACCTcctgcgcccttctTACATATGATATCTCGACTAtatcaaaacccattcgttt c" /listShort="gerE, S1075, ysmB, racE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2529391..2529834) /gene="ysmA" /locus_tag="BSU_28420" /old_locus_tag="BSU28420" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390720.1" /db_xref="EnsemblGenomes-Gn:BSU28420" /db_xref="EnsemblGenomes-Tr:CAB14802" /db_xref="InterPro:IPR006683" /db_xref="InterPro:IPR029069" /db_xref="SubtiList:BG10354" /db_xref="UniProtKB/Swiss-Prot:P11469" /translation="MKLPAYIDMPFQEWKTSFSFFNKVSVRFSETDMFGHMNNVTPFI YFEEVRISYFKKLNMMSENKQTMTVVASQQCDYLRQVMPYEELRIYVKTSAVGSSSLT LHYLGENLEGEPCFTGAVVMVQVSKESGKAVSWTDEEKETLLHTR*" /label="ysmA CDS" gene complement(2529391..2529834) /gene="ysmA" /locus_tag="BSU_28420" /old_locus_tag="BSU28420" /label="ysmA gene" CDS complement(2529895..2530656) /gene="sdhB" /locus_tag="BSU_28430" /old_locus_tag="BSU28430" /EC_number="1.3.5.1" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11803018, 1707123, 22720735, 22389480, 22790590" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11803018, 1707123, 22720735, 22389480, 22790590; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="succinate dehydrogenase (iron-sulfur protein)" /protein_id="NP_390721.1" /db_xref="EnsemblGenomes-Gn:BSU28430" /db_xref="EnsemblGenomes-Tr:CAB14803" /db_xref="GOA:P08066" /db_xref="InterPro:IPR004489" /db_xref="InterPro:IPR009051" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR017900" /db_xref="InterPro:IPR025192" /db_xref="InterPro:IPR036010" /db_xref="SubtiList:BG10353" /db_xref="UniProtKB/Swiss-Prot:P08066" /translation="MSEQKTIRFIITRQDTADSTPYDEEFEIPYRPNLNVISALMEIR RNPVNVKGEKTTPVTWDMNCLEEVCGACSMVINGKPRQSCTALIDQLEQPIRLKPMKT FPVVRDLQVDRSRMFDSLKKVKAWIPIDGTYDLGPGPRMPEKRRQWAYELSKCMTCGV CLEACPNVNSKSKFMGPAPMSQVRLFNAHPTGAMNKSERLEALMDEGGLADCGNSQNC VQSCPKGIPLTTSIAALNRDTNLQAFRNFFGSDRV*" /label="sdhB CDS" gene complement(2529895..2530656) /gene="sdhB" /locus_tag="BSU_28430" /old_locus_tag="BSU28430" /label="sdhB gene" downshifts complement(2529903) /Source="Nicolas_upshifts" /id="D1455" /incds=0 /nref=61 /ntot=257 /MaxReadThrough="5.46426" /MaxDrop="4.6864" /score="20.9204638" /energy="-10.8" /TU="U2202" /idTUdmin="U2205" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(2530659..2532419) /gene="sdhA" /locus_tag="BSU_28440" /old_locus_tag="BSU28440" /EC_number="1.3.5.1" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11803018, 1707123, 18535631, 22389480, 22790590" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11803018, 1707123, 18535631, 22389480, 22790590; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="succinate dehydrogenase (flavoprotein subunit)" /protein_id="NP_390722.2" /db_xref="EnsemblGenomes-Gn:BSU28440" /db_xref="EnsemblGenomes-Tr:CAB14804" /db_xref="GOA:P08065" /db_xref="InterPro:IPR003952" /db_xref="InterPro:IPR003953" /db_xref="InterPro:IPR011280" /db_xref="InterPro:IPR015939" /db_xref="InterPro:IPR027477" /db_xref="InterPro:IPR036188" /db_xref="InterPro:IPR037099" /db_xref="SubtiList:BG10352" /db_xref="UniProtKB/Swiss-Prot:P08065" /translation="MSQSSIIVVGGGLAGLMATIKAAESGMAVKLFSIVPVKRSHSVC AQGGINGAVNTKGEGDSPWEHFDDTVYGGDFLANQPPVKAMCEAAPSIIHLLDRMGVM FNRTPEGLLDFRRFGGTQHHRTAYAGATTGQQLLYALDEQVRRYEVAGLVTKYEGWEF LGAVLDDDRTCRGIVAQNLTNMQIESFRSDAVIMATGGPGIIFGKSTNSMINTGSAAS IVYQQGAYYANGEFIQIHPTAIPGDDKLRLMSESARGEGGRVWTYKDGKPWYFLEEKY PAYGNLVPRDIATREIFDVCVNQKLGINGENMVYLDLSHKDPKELDIKLGGIIEIYEK FMGDDPRKLPMKIFPAVHYSMGGLWVDYDQMTNIPGLFAAGECDYSMHGGNRLGANSL LSAIYGGMVAGPNAVKYVNGLESSAEDMSSSLFDAHVKKEEEKWADIMSMDGTENAYV LHKELGEWMTANVTVVRHNDKLLKTDDKIQELMERFKKININDTTKWSNQGAMFTRQF SNMLQLARVITLGAYNRNESRGAHYKPDYPERNDDEWLKTTMAKHVSPYEAPEFEYQD VDVSLITPRKRDYSKKKVAK*" /label="sdhA CDS" gene complement(2530659..2532419) /gene="sdhA" /locus_tag="BSU_28440" /old_locus_tag="BSU28440" /label="sdhA gene" CDS complement(2532453..2533061) /gene="sdhC" /locus_tag="BSU_28450" /old_locus_tag="BSU28450" /EC_number="1.3.5.1" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:11803018, 15849754, 16850406, 1707123, 18535631, 22389480, 22389480" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11803018, 15849754, 16850406, 1707123, 18535631, 22389480, 22389480; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="succinate dehydrogenase (cytochrome b558 subunit)" /protein_id="NP_390723.1" /db_xref="EnsemblGenomes-Gn:BSU28450" /db_xref="EnsemblGenomes-Tr:CAB14805" /db_xref="GOA:P08064" /db_xref="InterPro:IPR000701" /db_xref="InterPro:IPR011138" /db_xref="InterPro:IPR016002" /db_xref="InterPro:IPR034804" /db_xref="SubtiList:BG10351" /db_xref="UniProtKB/Swiss-Prot:P08064" /translation="MSGNREFYFRRLHSLLGVIPVGIFLIQHLVVNQFAARGAEAFNS AAHFMDSLPFRYALEIFIIFLPLIYHAVYGVYIAFTAKNNAGQYSYMRNWLFVLQRVT GIITLIFVSWHVWETRIAAQMGAEVNFDMMANILSSPAMLGFYIVGVLSTIFHFSNGL WSFAVTWGITVTPRSQRISTYVTLIIFVALSYVGLKAIFAFV*" /label="sdhC CDS" gene complement(2532453..2533061) /gene="sdhC" /locus_tag="BSU_28450" /old_locus_tag="BSU28450" /label="sdhC gene" promotor_-35 2532831..2532838 /Source="Nicolas_upshift_promotors" /id="U2201" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.545454545454545" /psig=1 /xcortree=646 /SigmaFactorBS="tagctgtattgaccggcgttatttttcgcagtaaacgcTATG TACAcaccataaactgCATGATAAATTAATGGTAAGaagataataaaaatttccaagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2532851..2532870 /Source="Nicolas_upshift_promotors" /id="U2201" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.545454545454545" /psig=1 /xcortree=646 /SigmaFactorBS="tagctgtattgaccggcgttatttttcgcagtaaacgcTATG TACAcaccataaactgCATGATAAATTAATGGTAAGaagataataaaaatttccaagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2532853 /Source="Nicolas_upshifts" /id="U2201" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.545454545454545" /psig=1 /xcortree=646 /SigmaFactorBS="tagctgtattgaccggcgttatttttcgcagtaaacgcTATG TACAcaccataaactgCATGATAAATTAATGGTAAGaagataataaaaatttccaagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2533062..2533157) /Source="Nicolas_S_feature" /locus_tag="new_2908738_2908833_c" /HighExp="Lbtran, dia5, Mt0, T0.30H, T1.0H, M0t90, M40t90, T0.0H, Glucon, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.78844099999999995" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1076" promotor_-10 complement(2533147..2533166) /Source="Nicolas_upshift_promotors" /id="U2202" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.766233766233766" /psig="0.999000999001" /xcortree=2226 /SigmaFactorBS="tcggaaaattataatttatgtacgcgtttTCTTGACGccctt ttgagggagGAGTAAAATGAAATTGTCAAtaaatcttaataaagtgcttacaattgaa a" /listShort="S1076, sdhC, sdhA, sdhB, ysmA, gerE, S1075" /listLong="ysmB, racE" /label="promotor_-10" upshifts complement(2533157) /Source="Nicolas_upshifts" /id="U2202" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.766233766233766" /psig="0.999000999001" /xcortree=2226 /SigmaFactorBS="tcggaaaattataatttatgtacgcgtttTCTTGACGccctt ttgagggagGAGTAAAATGAAATTGTCAAtaaatcttaataaagtgcttacaattgaa a" /listShort="S1076, sdhC, sdhA, sdhB, ysmA, gerE, S1075" /listLong="ysmB, racE" /label="upshifts" S_feature complement(2533159..2533780) /Source="Nicolas_S_feature" /locus_tag="new_2908835_2909456_c" /HighExp="MG 120, B36, UNK1, Fru, MG 150, BMM, Gly, Glucon, Glu, GM-0.1" /AntisenseName="yslB" /AntisenseCor="-0.44143968421748903" /AntisenseRegPval="-13.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1077" promotor_-35 complement(2533181..2533188) /Source="Nicolas_upshift_promotors" /id="U2202" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.766233766233766" /psig="0.999000999001" /xcortree=2226 /SigmaFactorBS="tcggaaaattataatttatgtacgcgtttTCTTGACGccctt ttgagggagGAGTAAAATGAAATTGTCAAtaaatcttaataaagtgcttacaattgaa a" /listShort="S1076, sdhC, sdhA, sdhB, ysmA, gerE, S1075" /listLong="ysmB, racE" /label="promotor_-35" promotor_-35 2533296..2533300 /Source="Nicolas_upshift_promotors" /id="U2203" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.612387612387612" /psig="0.995004995004995" /xcortree=2758 /SigmaFactorBS="cttaatttttcataagaattacaggatcatTCTGTaatcctc ccccctgttTGAGCTATAATATACGCAGGagagaggggagacagatatgaagtctaaa t" /listShort="yslB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_no_box 2533310..2533410 /Source="Nicolas_upshift_promotors" /id="U2204" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.631368631368631" /psig="0.024975024975025" /xcortree=1731 /SigmaFactorBS="ccctgtttgagctataatatacgcaggagagaggggagacag atatgaagtctaaatttgaagcatctattgacaacctaaaagaaattgaaatgaacgc t" /listShort="yslB" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-10 2533317..2533336 /Source="Nicolas_upshift_promotors" /id="U2203" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.612387612387612" /psig="0.995004995004995" /xcortree=2758 /SigmaFactorBS="cttaatttttcataagaattacaggatcatTCTGTaatcctc ccccctgttTGAGCTATAATATACGCAGGagagaggggagacagatatgaagtctaaa t" /listShort="yslB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2533326 /Source="Nicolas_upshifts" /id="U2203" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.612387612387612" /psig="0.995004995004995" /xcortree=2758 /SigmaFactorBS="cttaatttttcataagaattacaggatcatTCTGTaatcctc ccccctgttTGAGCTATAATATACGCAGGagagaggggagacagatatgaagtctaaa t" /listShort="yslB" /GFF_Attribute="listLong" /label="upshifts" CDS 2533354..2533800 /gene="yslB" /locus_tag="BSU_28460" /old_locus_tag="BSU28460" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390724.1" /db_xref="EnsemblGenomes-Gn:BSU28460" /db_xref="EnsemblGenomes-Tr:CAB14806" /db_xref="InterPro:IPR019642" /db_xref="InterPro:IPR024096" /db_xref="PDB:3NJC" /db_xref="SubtiList:BG11236" /db_xref="UniProtKB/Swiss-Prot:P42955" /translation="MKSKFEASIDNLKEIEMNAYAYELIREIVLPDMLGQDYSSMMYW AGKHLARKFPLESWEEFPAFFEEAGWGTLTNVSAKKQELEFELEGPIISNRLKHQKEP CFQLEAGFIAEQIQLMNDQIAESYEQVKKRADKVVLTVKWDMKDPV*" /label="yslB CDS" gene 2533354..2533800 /gene="yslB" /locus_tag="BSU_28460" /old_locus_tag="BSU28460" /label="yslB gene" upshifts 2533370 /Source="Nicolas_upshifts" /id="U2204" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.631368631368631" /psig="0.024975024975025" /xcortree=1731 /SigmaFactorBS="ccctgtttgagctataatatacgcaggagagaggggagacag atatgaagtctaaatttgaagcatctattgacaacctaaaagaaattgaaatgaacgc t" /listShort="yslB" /GFF_Attribute="listLong" /label="upshifts" downshifts 2533788 /Source="Nicolas_upshifts" /id="D1456" /incds=0 /nref=217 /ntot=255 /MaxReadThrough="2.21897" /MaxDrop="6.5759" /score="4.74486914" /energy="-10.8" /TU="NA" /idTUdmin="U2203" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2533826) /Source="Nicolas_upshifts" /id="D1457" /incds=0 /nref=8 /ntot=160 /MaxReadThrough="5.89867" /MaxDrop="4.19639" /score="2.38159916" /energy="-10.8" /TU="U2205" /idTUdmin="U2206" /TUdmin=1270 /isTUend="FALSE" /label="downshifts" CDS complement(2533844..2535070) /gene="lysCA" /locus_tag="BSU_28470" /old_locus_tag="BSU28470" /EC_number="2.7.2.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2981221, 2981222, 14597663, 1980002, 8757727, 9851048" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2981221, 2981222, 14597663, 1980002, 8757727, 9851048; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="aspartokinase II alpha subunit (aa 1->408)" /protein_id="NP_390725.1" /db_xref="EnsemblGenomes-Gn:BSU28470" /db_xref="EnsemblGenomes-Tr:CAB14807" /db_xref="GOA:P08495" /db_xref="InterPro:IPR001048" /db_xref="InterPro:IPR001341" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR005260" /db_xref="InterPro:IPR018042" /db_xref="InterPro:IPR027795" /db_xref="InterPro:IPR036393" /db_xref="SubtiList:BG10350" /db_xref="UniProtKB/Swiss-Prot:P08495" /translation="MGLIVQKFGGTSVGSVEKIQNAANRAIAEKQKGHQVVVVVSAMG KSTDELVSLAKAISDQPSKREMDMLLATGEQVTISLLSMALQEKGYDAVSYTGWQAGI RTEAIHGNARITDIDTSVLADQLEKGKIVIVAGFQGMTEDCEITTLGRGGSDTTAVAL AAALKADKCDIYTDVPGVFTTDPRYVKSARKLEGISYDEMLELANLGAGVLHPRAVEF AKNYQVPLEVRSSTETEAGTLIEEESSMEQNLIVRGIAFEDQITRVTIYGLTSGLTTL STIFTTLAKRNINVDIIIQTQAEDKTGISFSVKTEDADQTVAVLEEYKDALEFEKIET ESKLAKVSIVGSGMVSNPGVAAEMFAVLAQKNILIKMVSTSEIKVSTVVSENDMVKAV ESLHDAFELSKHPSAV*" /label="lysCA CDS" CDS complement(2533844..2534335) /gene="lysCB" /locus_tag="BSU_28475" /old_locus_tag="BSU28475" /EC_number="2.7.2.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1980002, 2981221, 2981222, 8757727, 9851048, 14597663" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1980002, 2981221, 2981222, 8757727, 9851048, 14597663; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="aspartokinase II beta subunit (aa 246->408)" /protein_id="YP_009513994.1" /translation="MEQNLIVRGIAFEDQITRVTIYGLTSGLTTLSTIFTTLAKRNIN VDIIIQTQAEDKTGISFSVKTEDADQTVAVLEEYKDALEFEKIETESKLAKVSIVGSG MVSNPGVAAEMFAVLAQKNILIKMVSTSEIKVSTVVSENDMVKAVESLHDAFELSKHP SAV*" /label="lysCB CDS" gene complement(2533844..2535070) /gene="lysCA" /locus_tag="BSU_28470" /old_locus_tag="BSU28470" /label="lysCA gene" gene complement(2533844..2534335) /gene="lysCB" /locus_tag="BSU_28475" /old_locus_tag="BSU28475" /label="lysCB gene" downshifts complement(2535184) /Source="Nicolas_upshifts" /id="D1458" /incds=0 /nref=1 /ntot=22 /MaxReadThrough="7.23315" /MaxDrop="4.15833" /score="31.7469619" /energy="-13.5" /TU="U2205,U2206" /idTUdmin="U2207" /TUdmin=44 /isTUend="FALSE" /label="downshifts" misc_RNA complement(2535196..2535375) /gene="kswC" /locus_tag="BSU_misc_RNA_46" /product="lysine riboswitch" /experiment="publication(s) with functional evidences, PMID:14523230, 14597663, 14627808, 21169337, 22416067" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14523230, 14597663, 14627808, 21169337, 22416067; Product type n: RNA" /label="kswC RNA" gene complement(2535196..2535375) /gene="kswC" /locus_tag="BSU_misc_RNA_46" /label="kswC gene" downshifts complement(2535228) /Source="Nicolas_upshifts" /id="D1459" /incds=0 /nref=22 /ntot=132 /MaxReadThrough="7.09997" /MaxDrop="4.61976" /score="31.7469619" /energy="-13.5" /TU="U2205,U2206" /idTUdmin="U2207" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2535400..2535419) /Source="Nicolas_upshift_promotors" /id="U2205" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.472527472527473" /psig=1 /xcortree=3002 /SigmaFactorBS="gctcctttacgacaaattgcaaaaataaTGTTGTCCttttaa ataagaTCTGATAAAATGTGAACTAAtttcatagttagatcgtgttatatggtgaaga t" /listShort="NA, lysC, S1077, S1076, sdhC, sdhA, sdhB" /listLong="ysmA, gerE" /label="promotor_-10" upshifts complement(2535407) /Source="Nicolas_upshifts" /id="U2205" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.472527472527473" /psig=1 /xcortree=3002 /SigmaFactorBS="gctcctttacgacaaattgcaaaaataaTGTTGTCCttttaa ataagaTCTGATAAAATGTGAACTAAtttcatagttagatcgtgttatatggtgaaga t" /listShort="NA, lysC, S1077, S1076, sdhC, sdhA, sdhB" /listLong="ysmA, gerE" /label="upshifts" promotor_-35 complement(2535432..2535439) /Source="Nicolas_upshift_promotors" /id="U2205" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.472527472527473" /psig=1 /xcortree=3002 /SigmaFactorBS="gctcctttacgacaaattgcaaaaataaTGTTGTCCttttaa ataagaTCTGATAAAATGTGAACTAAtttcatagttagatcgtgttatatggtgaaga t" /listShort="NA, lysC, S1077, S1076, sdhC, sdhA, sdhB" /listLong="ysmA, gerE" /label="promotor_-35" CDS complement(2535440..2537212) /gene="uvrC" /locus_tag="BSU_28490" /old_locus_tag="BSU28490" /EC_number="4.1.99.3" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:8655545, 16267290, 16426634, 25713353" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8655545, 16267290, 16426634, 25713353; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="excinuclease ABC (subunit C)" /protein_id="NP_390727.2" /db_xref="EnsemblGenomes-Gn:BSU28490" /db_xref="EnsemblGenomes-Tr:CAB14809" /db_xref="GOA:P14951" /db_xref="InterPro:IPR000305" /db_xref="InterPro:IPR001162" /db_xref="InterPro:IPR001943" /db_xref="InterPro:IPR004791" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR035901" /db_xref="InterPro:IPR036876" /db_xref="SubtiList:BG10349" /db_xref="UniProtKB/Swiss-Prot:P14951" /translation="MNKQLKEKLALLPDQPGCYLMKDRQQTVIYVGKAKVLKNRVRSY FTGSHDAKTQRLVTEIEDFEYIVTSSNLEALILEMNLIKKHDPKYNVMLKDDKTYPFI KLTHERHPRLIVTRNVKKDKGRYFGPYPNVQAARETKKLLDRLYPLRKCSKLPDRVCL YYHLGQCLAPCVKDISEETNRELVESITRFLRGGYNEVKKELEEKMHEAAENLEFERA KELRDQIAHIESTMEKQKMTMNDLVDRDVFAYAYDKGWMCVQVFFIRQGKLIERDVSM FPLYQEADEEFLTFIGQFYSKNNHFLPKEILVPDSIDQSMIEQLLETNVHQPKKGPKK ELLMLAHKNAKIALKEKFSLIERDEERSIGAVQKLGEALNIYTPHRIEAFDNSNIQGT NPVSAMIVFIDGKPYKKEYRKYKIKTVTGPDDYGSMREVVRRRYTRVLRENLPLPDLI IIDGGKGQINAARDVIENELGLDIPIAGLAKDEKHRTSNLLIGDPLEVAYLERNSQEF YLLQRIQDEVHRFAISFHRQIRGKSAFQSVLDDIPGIGEKRKKMLLKHFGSVKKMKEA SLEDIKKAGVPAAAAQLLYDKLQK*" /label="uvrC CDS" gene complement(2535440..2537212) /gene="uvrC" /locus_tag="BSU_28490" /old_locus_tag="BSU28490" /label="uvrC gene" promotor_-10 complement(2537239..2537258) /Source="Nicolas_upshift_promotors" /id="U2206" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2092 /SigmaFactorBS="tgagggatcgctttttttattcgccaattgtgaaCCATAGAG aaaaacaaacgttCGTGTTAAACTGGAAATAAAggattaaacataaggaagggtaaca t" /listShort="uvrC, NA" /listLong="lysC, S1077, S1076, sdhC, sdhA, sdhB, ysmA" /label="promotor_-10" upshifts complement(2537253) /Source="Nicolas_upshifts" /id="U2206" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2092 /SigmaFactorBS="tgagggatcgctttttttattcgccaattgtgaaCCATAGAG aaaaacaaacgttCGTGTTAAACTGGAAATAAAggattaaacataaggaagggtaaca t" /listShort="uvrC, NA" /listLong="lysC, S1077, S1076, sdhC, sdhA, sdhB, ysmA" /label="upshifts" promotor_-35 complement(2537272..2537279) /Source="Nicolas_upshift_promotors" /id="U2206" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2092 /SigmaFactorBS="tgagggatcgctttttttattcgccaattgtgaaCCATAGAG aaaaacaaacgttCGTGTTAAACTGGAAATAAAggattaaacataaggaagggtaaca t" /listShort="uvrC, NA" /listLong="lysC, S1077, S1076, sdhC, sdhA, sdhB, ysmA" /label="promotor_-35" downshifts complement(2537342) /Source="Nicolas_upshifts" /id="D1460" /incds=0 /nref=237 /ntot=268 /MaxReadThrough="4.77689" /MaxDrop="6.41061" /score="23.4086154" /energy="-10.5" /TU="U2207,U2208" /idTUdmin="U2209" /TUdmin=373 /isTUend="FALSE" /label="downshifts" CDS complement(2537348..2537662) /gene="trxA" /locus_tag="BSU_28500" /old_locus_tag="BSU28500" /function="16.6: Maintain" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9537387, 12682299, 1459769, 15937154, 17303556, 18455736, 18601268" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9537387, 12682299, 1459769, 15937154, 17303556, 18455736, 18601268; Product type c: carrier" /codon_start=1 /transl_table=11 /product="thioredoxin" /protein_id="NP_390728.1" /db_xref="EnsemblGenomes-Gn:BSU28500" /db_xref="EnsemblGenomes-Tr:CAB14810" /db_xref="GOA:P14949" /db_xref="InterPro:IPR005746" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR017937" /db_xref="InterPro:IPR036249" /db_xref="PDB:2GZY" /db_xref="PDB:2GZZ" /db_xref="PDB:2IPA" /db_xref="PDB:2VOC" /db_xref="SubtiList:BG10348" /db_xref="UniProtKB/Swiss-Prot:P14949" /translation="MAIVKATDQSFSAETSEGVVLADFWAPWCGPCKMIAPVLEELDQ EMGDKLKIVKIDVDENQETAGKYGVMSIPTLLVLKDGEVVETSVGFKPKEALQELVNK HL*" /label="trxA CDS" gene complement(2537348..2537662) /gene="trxA" /locus_tag="BSU_28500" /old_locus_tag="BSU28500" /label="trxA gene" promotor_-10 complement(2537688..2537707) /Source="Nicolas_upshift_promotors" /id="U2207" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.496503496503497" /psig="0.995004995004995" /xcortree=1940 /SigmaFactorBS="gctgtgatcaggaaaaaataatttgtaagcattaaaaTAGcg tgaacgaatgggaGATGCTATACTAAAAATCATcatttcacattggaggaattcaata a" /listShort="trxA, uvrC, NA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2537702) /Source="Nicolas_upshifts" /id="U2207" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.496503496503497" /psig="0.995004995004995" /xcortree=1940 /SigmaFactorBS="gctgtgatcaggaaaaaataatttgtaagcattaaaaTAGcg tgaacgaatgggaGATGCTATACTAAAAATCATcatttcacattggaggaattcaata a" /listShort="trxA, uvrC, NA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2537704..2537913) /Source="Nicolas_S_feature" /locus_tag="new_2913380_2913589_c" /HighExp="Etha, Salt, Gly, Sw, M9-stat, LPhT, BC, B60, S5, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99984399999999996" /TUshortSig="SigB, SigA" /TUshortPSig="0.991, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1078" promotor_-35 complement(2537723..2537725) /Source="Nicolas_upshift_promotors" /id="U2207" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.496503496503497" /psig="0.995004995004995" /xcortree=1940 /SigmaFactorBS="gctgtgatcaggaaaaaataatttgtaagcattaaaaTAGcg tgaacgaatgggaGATGCTATACTAAAAATCATcatttcacattggaggaattcaata a" /listShort="trxA, uvrC, NA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2537807..2537917) /locus_tag="BSU_28509" /old_locus_tag="BSU28509" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="CDS C-terminal fragment" /db_xref="PSEUDO:SOX90589.1" /translation="MVKYMTVKRRCDLMLRTILMIIGAIVVIGAIIRFVF*" /label="CDS C-terminal fragment" gene complement(2537807..2537917) /locus_tag="BSU_28509" /old_locus_tag="BSU28509" /pseudo /label="gene" promotor_-10 complement(2537903..2537921) /Source="Nicolas_upshift_promotors" /id="U2208" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=165 /SigmaFactorBS="cgccggagcttcatgccggcgctctttttcaGGTTTTAaaac agctccggcaGGGCATGGTAAAGTACATGacagtgaagaggagatgtgatcttatgct t" /listShort="S1078, trxA, uvrC" /listLong="NA" /label="promotor_-10" upshifts complement(2537913) /Source="Nicolas_upshifts" /id="U2208" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=165 /SigmaFactorBS="cgccggagcttcatgccggcgctctttttcaGGTTTTAaaac agctccggcaGGGCATGGTAAAGTACATGacagtgaagaggagatgtgatcttatgct t" /listShort="S1078, trxA, uvrC" /listLong="NA" /label="upshifts" promotor_-35 complement(2537936..2537942) /Source="Nicolas_upshift_promotors" /id="U2208" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=165 /SigmaFactorBS="cgccggagcttcatgccggcgctctttttcaGGTTTTAaaac agctccggcaGGGCATGGTAAAGTACATGacagtgaagaggagatgtgatcttatgct t" /listShort="S1078, trxA, uvrC" /listLong="NA" /label="promotor_-35" CDS complement(2537985..2539472) /gene="abfB" /locus_tag="BSU_28510" /old_locus_tag="BSU28510" /EC_number="3.2.1.55" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14973026, 17827291, 18757805" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14973026, 17827291, 18757805; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exo-alpha-L-arabinofuranosidase" /protein_id="NP_390729.2" /db_xref="EnsemblGenomes-Gn:BSU28510" /db_xref="EnsemblGenomes-Tr:CAB14811" /db_xref="GOA:P94552" /db_xref="InterPro:IPR010720" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG11985" /db_xref="UniProtKB/Swiss-Prot:P94552" /translation="MSEHQAVIQTDIAKGTINKNIYGHFAEHLGRGIYEGIWVGTDSD IPNINGIRKDVLEALKQLHIPVLRWPGGCFADEYHWANGVGDRKTMLNTHWGGTIESN EFGTHEFMMLCELLECEPYICGNVGSGTVQEMSEWIEYMTFEEGTPMSDWRKQNGREE PWKLKYFGVGNENWGCGGNMHPEYYADLYRRFQTYVRNYSGNDIYKIAGGANVDDFNW TDVLMKKAAGLMDGLSLHYYTIPGDFWKGKGSATEFTEDEWFITMKKAKYIDELIQKH GTIMDRYDPEQRVGLIIDEWGTWFDPEPGTNPGFLYQQNTIRDALVAASHFHIFHQHC RRVQMANIAQTVNVLQAMILTEGERMLLTPTYHVFNMFKVHQDASLLATETMSADYEW NGETLPQISISASKQAEGDINITICNIDHQNKAEAEIELRGLHKAADHSGVILTAEKM NAHNTFDDPHHVKPESFRQYTLSKNKLKVKLPPMSVVLLTLRADS*" /label="abfB CDS" gene complement(2537985..2539472) /gene="abfB" /locus_tag="BSU_28510" /old_locus_tag="BSU28510" /label="abfB gene" S_feature complement(2539473..2539585) /Source="Nicolas_S_feature" /locus_tag="new_2915149_2915261_c" /HighExp="T0.30H, M40t90, M0t90, BC, M9-stat, T1.30H, T1.0H, T2.0H, T2.30H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1079" promotor_-10 complement(2539566..2539585) /Source="Nicolas_upshift_promotors" /id="U2209" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=367 /SigmaFactorBS="aaatacatacgtacaaatataaaaacaatagaaaatgtCGTT GACAtgtacgaacatataTAATATGGTTACTTTAAAAGcgcttacattcatgctgact c" /listShort="S1079, xsa, S1078" /listLong="trxA" /label="promotor_-10" upshifts complement(2539585) /Source="Nicolas_upshifts" /id="U2209" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=367 /SigmaFactorBS="aaatacatacgtacaaatataaaaacaatagaaaatgtCGTT GACAtgtacgaacatataTAATATGGTTACTTTAAAAGcgcttacattcatgctgact c" /listShort="S1079, xsa, S1078" /listLong="trxA" /label="upshifts" promotor_-35 complement(2539600..2539607) /Source="Nicolas_upshift_promotors" /id="U2209" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=367 /SigmaFactorBS="aaatacatacgtacaaatataaaaacaatagaaaatgtCGTT GACAtgtacgaacatataTAATATGGTTACTTTAAAAGcgcttacattcatgctgact c" /listShort="S1079, xsa, S1078" /listLong="trxA" /label="promotor_-35" CDS complement(2539689..2540666) /gene="etfA" /locus_tag="BSU_28520" /old_locus_tag="BSU28520" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17189250, 20059546, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 20059546, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="electron transfer flavoprotein (alpha subunit)" /protein_id="NP_390730.1" /db_xref="EnsemblGenomes-Gn:BSU28520" /db_xref="EnsemblGenomes-Tr:CAB14812" /db_xref="GOA:P94551" /db_xref="InterPro:IPR001308" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR014730" /db_xref="InterPro:IPR014731" /db_xref="InterPro:IPR018206" /db_xref="InterPro:IPR029035" /db_xref="InterPro:IPR033947" /db_xref="SubtiList:BG11934" /db_xref="UniProtKB/Swiss-Prot:P94551" /translation="MGKKVIVLGEIRDGELRNVTFEAIAAGRTISGDGEVIGVLIGEN VQSIAQELIHYGADKVLTAEDPKLKTYTADGYSQVMRGVIEQENPDSVIFGHTAMGKD LSPKLAARLQTGLISDAIDVSVTGGNVVFTRPIYSGKAFERVISTDPMIFATIRPNNI QASEKDTSRSGSIESIDVSLTDLRTVIQEVVKKTADGVDLSEAKIIVAGGRGVKSKEG FQPLQELAEVLGAAVGASRGACDADYCDYALQIGQTGKVVTPDLYIACGISGAIQHLA GMSNSKVIVAINKDPEADIFKIADYGIVGDLFEVVPLLTEEFKQLNIHS*" /label="etfA CDS" gene complement(2539689..2540666) /gene="etfA" /locus_tag="BSU_28520" /old_locus_tag="BSU28520" /label="etfA gene" downshifts complement(2539697) /Source="Nicolas_upshifts" /id="D1461" /incds=0 /nref=58 /ntot=179 /MaxReadThrough="2.43782" /MaxDrop="7.95053" /score="30.2462458" /energy="-13.5" /TU="NA" /idTUdmin="U2210" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(2540702..2541475) /gene="etfB" /locus_tag="BSU_28530" /old_locus_tag="BSU28530" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10026281, 17189250, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10026281, 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="electron transfer flavoprotein (beta subunit)" /protein_id="NP_390731.1" /db_xref="EnsemblGenomes-Gn:BSU28530" /db_xref="EnsemblGenomes-Tr:CAB14813" /db_xref="GOA:P94550" /db_xref="InterPro:IPR000049" /db_xref="InterPro:IPR012255" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR014730" /db_xref="InterPro:IPR033948" /db_xref="SubtiList:BG11935" /db_xref="UniProtKB/Swiss-Prot:P94550" /translation="MNLFVLMKRTFDTEEKIVIETGKIQDDGAEWIINPYDEYAIEEA IQLKEKHGGTITAVTVGGEEAEKELRTALAMGCDQAVLINIEDDLDEPDQYSISQVLY HYMKDQEFDLILGGNVAIDGGSGQVAPRLAELLDIPCITTITKLEINGTDAEAERDVE GDVEKIKTTLPLLVTAQQGLNEPRYPSLPGIMKAKKKPLEELELDDLDLDEEDAEPKL KTIERFLPPKKEAGKLLQGEPAEQAKELVSLLRSEAKVI*" /label="etfB CDS" gene complement(2540702..2541475) /gene="etfB" /locus_tag="BSU_28530" /old_locus_tag="BSU28530" /label="etfB gene" CDS complement(2541490..2542266) /gene="fadB" /locus_tag="BSU_28540" /old_locus_tag="BSU28540" /EC_number="4.2.1.17" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17189250, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enoyl-CoA hydratase" /protein_id="NP_390732.1" /db_xref="EnsemblGenomes-Gn:BSU28540" /db_xref="EnsemblGenomes-Tr:CAB14814" /db_xref="GOA:P94549" /db_xref="InterPro:IPR001753" /db_xref="InterPro:IPR014748" /db_xref="InterPro:IPR018376" /db_xref="InterPro:IPR029045" /db_xref="SubtiList:BG12331" /db_xref="UniProtKB/Swiss-Prot:P94549" /translation="MNAISLAVDQFVAVLTIHNPPANALSSRILEELSSCLDQCETDA GVRSIIIHGEGRFFSAGADIKEFTSLKGNEDSSLLAERGQQLMERIESFPKPIIAAIH GAALGGGLELAMACHIRIAAEDAKLGLPELNLGIIPGFAGTQRLPRYVGTAKALELIG SGEPISGKEALDLGLVSIGAKDEAEVIEKAKALAAKFAEKSPQTLASLLELLYSNKVY SYEGSLKLEAKRFGEAFESEDAKEGIQAFLEKRKPQFKGE*" /label="fadB CDS" gene complement(2541490..2542266) /gene="fadB" /locus_tag="BSU_28540" /old_locus_tag="BSU28540" /label="fadB gene" downshifts 2541555 /Source="Nicolas_upshifts" /id="D1462" /incds=1 /nref=1 /ntot=21 /MaxReadThrough="0.92259" /MaxDrop="4.42725" /score="-8.29305955" /energy="-5.1" /TU="NA" /idTUdmin="U2203" /TUdmin=7767 /isTUend="FALSE" /label="downshifts" CDS complement(2542281..2542865) /gene="fadR" /locus_tag="BSU_28550" /old_locus_tag="BSU28550" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17189250, 18941141, 21398533, 24356978" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 18941141, 21398533, 24356978; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of fatty acids degradation [FadR-long-chain (C14-C20) acyl-CoAs]" /protein_id="NP_390733.1" /db_xref="EnsemblGenomes-Gn:BSU28550" /db_xref="EnsemblGenomes-Tr:CAB14815" /db_xref="GOA:P94548" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR013570" /db_xref="InterPro:IPR036271" /db_xref="PDB:1VI0" /db_xref="PDB:3WHB" /db_xref="PDB:3WHC" /db_xref="SubtiList:BG12330" /db_xref="UniProtKB/Swiss-Prot:P94548" /translation="MKQKRPKYMQIIDAAVEVIAENGYHQSQVSKIAKQAGVADGTIY LYFKNKEDILISLFKEKMGQFIERMEEDIKEKATAKEKLALVISKHFSLLAGDHNLAI VTQLELRQSNLELRQKINEILKGYLNILDGILTEGIQSGEIKEGLDVRLARQMIFGTI DETVTTWVMNDQKYDLVALSNSVLELLVSGIHNK*" /label="fadR CDS" gene complement(2542281..2542865) /gene="fadR" /locus_tag="BSU_28550" /old_locus_tag="BSU28550" /label="fadR gene" promotor_-10 complement(2542907..2542926) /Source="Nicolas_upshift_promotors" /id="U2210" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.596403596403596" /psig=1 /xcortree=372 /SigmaFactorBS="aaagagaacgcctatgaataaACTTGACAaacctgaaaatcC TTCTTATCATGAAATTATGaatgaatagtcattcatttctataggaaggaacgatgaa c" /listShort="fadR, fadB, etfB, etfA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2542907) /Source="Nicolas_upshifts" /id="U2210" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.596403596403596" /psig=1 /xcortree=372 /SigmaFactorBS="aaagagaacgcctatgaataaACTTGACAaacctgaaaatcC TTCTTATCATGAAATTATGaatgaatagtcattcatttctataggaaggaacgatgaa c" /listShort="fadR, fadB, etfB, etfA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2542939..2542946) /Source="Nicolas_upshift_promotors" /id="U2210" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.596403596403596" /psig=1 /xcortree=372 /SigmaFactorBS="aaagagaacgcctatgaataaACTTGACAaacctgaaaatcC TTCTTATCATGAAATTATGaatgaatagtcattcatttctataggaaggaacgatgaa c" /listShort="fadR, fadB, etfB, etfA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2542970..2544652) /gene="lcfA" /locus_tag="BSU_28560" /old_locus_tag="BSU28560" /EC_number="6.2.1.3" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17085570, 17189250, 21398533, 21673922" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17085570, 17189250, 21398533, 21673922; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="long chain acyl-CoA ligase (degradative)" /protein_id="NP_390734.1" /db_xref="EnsemblGenomes-Gn:BSU28560" /db_xref="EnsemblGenomes-Tr:CAB14816" /db_xref="GOA:P94547" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="SubtiList:BG11946" /db_xref="UniProtKB/Swiss-Prot:P94547" /translation="MQSQKPWLAEYPNDIPHELPLPNKTLQSILTDSAARFPDKTAIS FYGKKLTFHDILTDALKLAAFLQCNGLQKGDRVAVMLPNCPQTVISYYGVLFAGGIVV QTNPLYTEHELEYQLRDAQVSVIITLDLLFPKAIKMKTLSIVDQILITSVKDYLPFPK NILYPLTQKQKVHIDFDKTANIHTFASCMKQEKTELLTIPKIDPEHDIAVLQYTGGTT GAPKGVMLTHQNILANTEMCAAWMYDVKEGAEKVLGIVPFFHVYGLTAVMNYSIKLGF EMILLPKFDPLETLKIIDKHKPTLFPGAPTIYIGLLHHPELQHYDLSSIKSCLSGSAA LPVEVKQKFEKVTGGKLVEGYGLSEASPVTHANFIWGKNKPGSIGCPWPSTDAAIYSE ETGELAAPYEHGEIIVKGPQVMKGYWNKPEETAAVLRDGWLFTGDMGYMDEEGFFYIA DRKKDIIIAGGYNIYPREVEEALYEHEAIQEIVVAGVPDSYRGETVKAFVVLKKGAKA DTEELDAFARSRLAPYKVPKAYEFRKELPKTAVGKILRRRLLEEETENHHIK*" /label="lcfA CDS" gene complement(2542970..2544652) /gene="lcfA" /locus_tag="BSU_28560" /old_locus_tag="BSU28560" /label="lcfA gene" misc_feature complement(2544681..2544700) /Source="Nicolas_upshift_promotors" /id="U2211" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.411588411588412" /psig="0.985014985014985" /xcortree=352 /SigmaFactorBS="tatgagaaaaagaaagatttacctttctttttcttttttttg ccgtccaTCTGCTATAATGATAAGGTGgatctctaaaatcgaaaggggaggttttatg c" /listShort="lcfA, fadR, fadB, etfB, etfA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2544689) /Source="Nicolas_upshifts" /id="U2211" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.411588411588412" /psig="0.985014985014985" /xcortree=352 /SigmaFactorBS="tatgagaaaaagaaagatttacctttctttttcttttttttg ccgtccaTCTGCTATAATGATAAGGTGgatctctaaaatcgaaaggggaggttttatg c" /listShort="lcfA, fadR, fadB, etfB, etfA" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(2544777) /Source="Nicolas_upshifts" /id="D1463" /incds=0 /nref=8 /ntot=101 /MaxReadThrough="2.17789" /MaxDrop="3.3655" /score="10.932726" /energy="-9.8" /TU="U2212" /idTUdmin="U2212" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(2544841..2545245) /gene="yshE" /locus_tag="BSU_28570" /old_locus_tag="BSU28570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390735.1" /db_xref="EnsemblGenomes-Gn:BSU28570" /db_xref="EnsemblGenomes-Tr:CAB14817" /db_xref="GOA:P94546" /db_xref="InterPro:IPR007140" /db_xref="SubtiList:BG12329" /db_xref="UniProtKB/Swiss-Prot:P94546" /translation="MSDFWENELVEIAAYYSVAVLCLVLFLTVFELVTAYKNWEEIQK GNLAVAMATGGKILGIANVFQHSISQHNSLLQMIGWGVYGFVMLLISYFIFEFLTPRF KIDQEIENDNRAVGFISFVISVGLSFVVAAGI*" /label="yshE CDS" gene complement(2544841..2545245) /gene="yshE" /locus_tag="BSU_28570" /old_locus_tag="BSU28570" /label="yshE gene" downshifts complement(2544843) /Source="Nicolas_upshifts" /id="D1464" /incds=0 /nref=1 /ntot=75 /MaxReadThrough="3.74343" /MaxDrop="2.92029" /score="10.932726" /energy="-9.8" /TU="U2212" /idTUdmin="U2212" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" CDS complement(2545260..2547617) /gene="mutSB" /locus_tag="BSU_28580" /old_locus_tag="BSU28580" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11254128, 12719520, 22333191, 27799325" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11254128, 12719520, 22333191, 27799325; Product type f: factor" /codon_start=1 /transl_table=11 /product="homologous recombination factor" /protein_id="NP_390736.1" /db_xref="EnsemblGenomes-Gn:BSU28580" /db_xref="EnsemblGenomes-Tr:CAB14818" /db_xref="GOA:P94545" /db_xref="InterPro:IPR000432" /db_xref="InterPro:IPR002625" /db_xref="InterPro:IPR005747" /db_xref="InterPro:IPR007696" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036063" /db_xref="InterPro:IPR036187" /db_xref="SubtiList:BG12328" /db_xref="UniProtKB/Swiss-Prot:P94545" /translation="MQQKVLSALEFHKVKEQVIGHAASSLGKEMLLELKPSASIDEIK KQLDEVDEASDIIRLRGQAPFGGLVDIRGALRRAEIGSVLSPSEFTEISGLLYAVKQM KHFITQMAEDGVDIPLIHQHAEQLITLSDLERDINSCIDDHGEVLDHASETLRGIRTQ LRTLESRVRDRLESMLRSSSASKMLSDTIVTIRNDRFVIPVKQEYRSSYGGIVHDTSS SGATLFIEPQAIVDMNNSLQQAKVKEKQEIERILRVLTEKTAEYTEELFLDLQVLQTL DFIFAKARYAKAVKATKPIMNDTGFIRLKKARHPLLPPDQVVANDIELGRDFSTIVIT GPNTGGKTVTLKTLGLLTLMAQSGLHIPADEGSEAAVFEHVFADIGDEQSIEQSLSTF SSHMVNIVGILEQVNENSLVLFDELGAGTDPQEGAALAMSILDDVHRTNARVLATTHY PELKAYGYNREGVMNASVEFDIETLSPTYKLLIGVPGRSNAFEISKRLGLPDHIIGQA KSEMTAEHNEVDTMIASLEQSKKRAEEELSETESIRKEAEKLHKELQQQIIELNSKKD KMLEEAEQQAAEKVKAAMKEAEDIIHELRTIKEEHKSFKDHELINAKKRLEGAMPAFE KSKKPEKPKTQKRDFKPGDEVKVLTFGQKGTLLEKTGGNEWNVQIGILKMKVKEKDLE FIKSAPEPKKEKMITAVKGKDYHVSLELDLRGERYENALSRVEKYLDDAVLAGYPRVS IIHGKGTGALRKGVQDLLKNHRSVKSSRFGEAGEGGSGVTVVELK*" /label="mutSB CDS" gene complement(2545260..2547617) /gene="mutSB" /locus_tag="BSU_28580" /old_locus_tag="BSU28580" /label="mutSB gene" CDS complement(2547638..2549350) /gene="polX" /locus_tag="BSU_28590" /old_locus_tag="BSU28590" /EC_number="2.7.7.7" /EC_number="3.1.11.-" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:18776221, 18938175, 28254425" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18776221, 18938175, 28254425; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase/3'-5' exonuclease X" /protein_id="NP_390737.1" /db_xref="EnsemblGenomes-Gn:BSU28590" /db_xref="EnsemblGenomes-Tr:CAB14819" /db_xref="GOA:P94544" /db_xref="InterPro:IPR002054" /db_xref="InterPro:IPR003141" /db_xref="InterPro:IPR003583" /db_xref="InterPro:IPR004013" /db_xref="InterPro:IPR010996" /db_xref="InterPro:IPR016195" /db_xref="InterPro:IPR022311" /db_xref="InterPro:IPR027421" /db_xref="InterPro:IPR029398" /db_xref="InterPro:IPR037160" /db_xref="SubtiList:BG12327" /db_xref="UniProtKB/Swiss-Prot:P94544" /translation="MHKKDIIRLLETIAVYMELKGDNPFKVSAFRKAAAALEQDDRSL SEMDDMMSLSGIGKGTYSVIKEYIDEGKSSTLESLQKEVPEGLVPLLKLPGLGGKKIA KLYKELGVHDAESLKEACEQQKVQGLAGFGKKSEEKILQALGEAGKQPERFPIGYALR IAREIEEHLSQFTHIIKFSRAGSLRRARETVKDLDYIIATDHPAEVREQLLELPNIKS VIASGDTKVSVILSFEYETSVDFRLVTEEQFPTTLHHFTGSKDHNIKMRQIAKERGER ISEYGVETVETGEIKTFPSEREFYAHFGLPLIPPEIRESGQEVETYSDSIELIELGQI KGDLHMHSTWSDGAFSIREMAEACIKKGYQYMAITDHSQYLKVANGLTAERLKQQAKE IDALNAEFENFRILKGVEMDILPDGTLDYDDDVLAEMDIVIASIHSSFNQPEHVIMKR LETALTNKHVDIIAHPTGRLIGRRAGYEIDIDQLIELARKTNTALELNANPARLDLRT EHLMKANEQGVTLVINTDAHNIEMLDDMKTGVTAARKGWTETKNVLNARSLKDVEAFL KRND*" /label="polX CDS" gene complement(2547638..2549350) /gene="polX" /locus_tag="BSU_28590" /old_locus_tag="BSU28590" /label="polX gene" S_feature complement(2549351..2549423) /Source="Nicolas_S_feature" /locus_tag="new_2925027_2925099_c" /HighExp="Cold, LPhT, LBGstat, H2O2, dia15, G180, G135, Sw, G150, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1080" CDS complement(2549424..2549957) /gene="yshB" /locus_tag="BSU_28600" /old_locus_tag="BSU28600" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_390738.1" /db_xref="EnsemblGenomes-Gn:BSU28600" /db_xref="EnsemblGenomes-Tr:CAB14820" /db_xref="GOA:P94543" /db_xref="InterPro:IPR003825" /db_xref="SubtiList:BG12326" /db_xref="UniProtKB/Swiss-Prot:P94543" /translation="MLDIIILILLLMGTLLGLKRGFILQFIRLTSFILSIAFAALFYK NVAPHLHWIPAPDFSAGQPALSFFTGNLEAAYYNAIAFIVLFIIAKILLRIIGSFLSI VAGIPVIKQINQMLGAVLGFLEVYLFTFVLLYVASVLPVDALQQMMGQSSLANVIINH TPYLSGLLQELWTQYGA*" /label="yshB CDS" gene complement(2549424..2549957) /gene="yshB" /locus_tag="BSU_28600" /old_locus_tag="BSU28600" /label="yshB gene" CDS complement(2549964..2550221) /gene="zapA" /locus_tag="BSU_28610" /old_locus_tag="BSU28610" /experiment="publication(s) with functional evidences, PMID:15317782, 16796675, 18588879, 20711458, 24097947, 26258635" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15317782, 16796675, 18588879, 20711458, 24097947, 26258635; Product type r : regulator" /codon_start=1 /transl_table=11 /product="regulator of cell division" /protein_id="NP_390739.1" /db_xref="EnsemblGenomes-Gn:BSU28610" /db_xref="EnsemblGenomes-Tr:CAB14821" /db_xref="GOA:P94542" /db_xref="InterPro:IPR007838" /db_xref="InterPro:IPR023688" /db_xref="InterPro:IPR036192" /db_xref="SubtiList:BG12325" /db_xref="UniProtKB/Swiss-Prot:P94542" /translation="MSDGKKTKTTVDIYGQHFTIVGEESRAHMRYVAGIVDDKMREIN EKNPYLDINKLAVLTAVNVVHDYVKLQEKCEKLERQLKEKD*" /label="zapA CDS" gene complement(2549964..2550221) /gene="zapA" /locus_tag="BSU_28610" /old_locus_tag="BSU28610" /label="zapA gene" promotor_-10 complement(2550248..2550267) /Source="Nicolas_upshift_promotors" /id="U2212" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2168 /SigmaFactorBS="tgtatataccagtgtatcataacagcgggaggctcgtcTTTC CATTcatttaataaaCGTGTTATGATAAGAACTAGgattctcgcggaatggaggagaa a" /listShort="yshA, yshB, S1080, polX, mutSB, yshE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2550264) /Source="Nicolas_upshifts" /id="U2212" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2168 /SigmaFactorBS="tgtatataccagtgtatcataacagcgggaggctcgtcTTTC CATTcatttaataaaCGTGTTATGATAAGAACTAGgattctcgcggaatggaggagaa a" /listShort="yshA, yshB, S1080, polX, mutSB, yshE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2550279..2550286) /Source="Nicolas_upshift_promotors" /id="U2212" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2168 /SigmaFactorBS="tgtatataccagtgtatcataacagcgggaggctcgtcTTTC CATTcatttaataaaCGTGTTATGATAAGAACTAGgattctcgcggaatggaggagaa a" /listShort="yshA, yshB, S1080, polX, mutSB, yshE" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 2550304..2550323 /Source="Nicolas_upshift_promotors" /id="U2213" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.987012987012987" /psig="0.999000999001" /xcortree=2131 /SigmaFactorBS="gttcttatcataacacgtttattaaatgaatggaaagacgag cctcccgctgtTATGATACACTGGTATATACagcgaaaagtgtaaaaaaaggagatta t" /listShort="rnhC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2550311 /Source="Nicolas_upshifts" /id="U2213" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.987012987012987" /psig="0.999000999001" /xcortree=2131 /SigmaFactorBS="gttcttatcataacacgtttattaaatgaatggaaagacgag cctcccgctgtTATGATACACTGGTATATACagcgaaaagtgtaaaaaaaggagatta t" /listShort="rnhC" /GFF_Attribute="listLong" /label="upshifts" CDS 2550355..2551296 /gene="rnhC" /locus_tag="BSU_28620" /old_locus_tag="BSU28620" /EC_number="3.1.26.4" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:9888800, 10094689, 12794188, 23882084" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9888800, 10094689, 12794188, 23882084; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease HIII" /protein_id="NP_390740.1" /db_xref="EnsemblGenomes-Gn:BSU28620" /db_xref="EnsemblGenomes-Tr:CAB14822" /db_xref="GOA:P94541" /db_xref="InterPro:IPR001352" /db_xref="InterPro:IPR004641" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR024567" /db_xref="InterPro:IPR024568" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG12324" /db_xref="UniProtKB/Swiss-Prot:P94541" /translation="MSHSVIKVSLSAIDQMKMTYSGSLTASVPQGAVFQAKPPGCTIT AYQSGKVLFQGKNAAAESARWGTAEPQEKKKTAKKPADPRYAPPADIAGMSVIGSDEV GTGDYFGPMTVVCAYVDKTMLPLMKELGVKDSKDLKDPQIIEIARNLIKTIPYSLLVL KNEKYNSMQEKGMSQGKMKALLHNQAITHLLRKLDGVKPEAILIDQFAEPGVYFNHLK GRDIVKERTYFSTKAEGIHLAVAAASIIARYSFLMEMDKLSRAAGMTLPKGAGPHVDE AAAKLILKKGASALRTFTKLHFANTQKAQRLADKKRS*" /label="rnhC CDS" gene 2550355..2551296 /gene="rnhC" /locus_tag="BSU_28620" /old_locus_tag="BSU28620" /label="rnhC gene" promotor_-10 complement(2551028..2551047) /Source="Nicolas_upshift_promotors" /id="U2214" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.586413586413586" /psig="0.998001998001998" /xcortree=2466 /SigmaFactorBS="gaatatcttgcaatgattgaagcagcggcgacagcCAGGTGA AtaccttcagctttTGTGCTAAAATAGGTCCGCTccttcacaatgtctctgcccttta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2551043) /Source="Nicolas_upshifts" /id="U2214" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.586413586413586" /psig="0.998001998001998" /xcortree=2466 /SigmaFactorBS="gaatatcttgcaatgattgaagcagcggcgacagcCAGGTGA AtaccttcagctttTGTGCTAAAATAGGTCCGCTccttcacaatgtctctgcccttta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2551061..2551068) /Source="Nicolas_upshift_promotors" /id="U2214" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.586413586413586" /psig="0.998001998001998" /xcortree=2466 /SigmaFactorBS="gaatatcttgcaatgattgaagcagcggcgacagcCAGGTGA AtaccttcagctttTGTGCTAAAATAGGTCCGCTccttcacaatgtctctgcccttta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2551279 /Source="Nicolas_upshifts" /id="D1465" /incds=0 /nref=150 /ntot=232 /MaxReadThrough="1.71535" /MaxDrop="5.25365" /score="25.6336933" /energy="-13.7" /TU="NA" /idTUdmin="U2213" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2551311) /Source="Nicolas_upshifts" /id="D1466" /incds=0 /nref=1 /ntot=5 /MaxReadThrough="2.4685" /MaxDrop="5.29665" /score="-4.45611985" /energy="-14.9" /TU="NA" /idTUdmin="U2216" /TUdmin=44 /isTUend="FALSE" /label="downshifts" CDS complement(2551332..2553746) /gene="pheT" /locus_tag="BSU_28630" /old_locus_tag="BSU28630" /EC_number="6.1.1.20" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:811647, 2127701, 2492510, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 811647, 2127701, 2492510, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phenylalanyl-tRNA synthetase (beta subunit)" /protein_id="NP_390741.1" /db_xref="EnsemblGenomes-Gn:BSU28630" /db_xref="EnsemblGenomes-Tr:CAB14823" /db_xref="GOA:P17922" /db_xref="InterPro:IPR002547" /db_xref="InterPro:IPR004532" /db_xref="InterPro:IPR005121" /db_xref="InterPro:IPR005146" /db_xref="InterPro:IPR005147" /db_xref="InterPro:IPR009061" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR020825" /db_xref="InterPro:IPR033714" /db_xref="InterPro:IPR036690" /db_xref="SubtiList:BG10875" /db_xref="UniProtKB/Swiss-Prot:P17922" /translation="MFVSYKWLEDYVDLKGMDPAVLAEKITRAGIEVEGIEYKGEGIK GVVIGHVLEREQHPNADKLNKCLVDIGAEAPVQIICGAPNVDKGQKVAVATVGAVLPG NFKIKKAKLRGEESNGMICSLQELGIESKLVAKEYAEGIFVFPNDAETGSDALAALQL DDAILELGLTPNRADAMNMLGVAYEVAAILDTEVKLPQTDYPAASEQASDYISVKIED QEANPLYTAKIIKNVTIAPSPLWMQTKLMNAGIRPHNNVVDITNFVLLEYGQPLHAFD YDRFGSKEVVVRKAAENEMIVTLDDQERKLSADHLVITNGTKAQAVAGVMGGAESEVQ EDTKTILLEAAYFNGQKVRKASKDLGLRSESSVRFEKGIDPARVRLAAERAAQLIHLY AGGEVLAGTVEEDHLTIEANNIHVSADKVSSVLGLTISKEELISIYKRLGFTVGEADD LLVVTVPSRRGDITIEEDLIEEAARLYGYDNIPSTLPETAGTTGGLTPYQAKRRKVRR FLEGAGLSQAITYSLTNEKKATAFAIEKSLNTVLALPMSEERSILRHSLVPNLLDSVS YNLARQTDSVALYEVGSVFLTKEEDTKPVETERVAGAVTGLWRKQLWQGEKKPVDFFV VKGIVEGLLDKLNVLDSIEFVQSERKQLHPGRTANILLNGSLIGFIGQVHPSLEKELD IKETYVFELDLHALLAAETAPLVYTAIPKYPSVTRDIALVTDKTVTSGQLESVIKEAG GKLLKEVTVFDVYEGEHMEEGKKSVAFSLQYVNPEQTLTEEEVTKAHSKVLKALEDTY QAVLRG*" /label="pheT CDS" gene complement(2551332..2553746) /gene="pheT" /locus_tag="BSU_28630" /old_locus_tag="BSU28630" /label="pheT gene" downshifts complement(2551355) /Source="Nicolas_upshifts" /id="D1467" /incds=0 /nref=214 /ntot=255 /MaxReadThrough="3.98669" /MaxDrop="7.11892" /score="32.4736491" /energy="-14.7" /TU="NA" /idTUdmin="U2216" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2553762..2554796) /gene="pheS" /locus_tag="BSU_28640" /old_locus_tag="BSU28640" /EC_number="6.1.1.20" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:811647, 2127701, 2492510, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 811647, 2127701, 2492510, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phenylalanyl-tRNA synthetase (alpha subunit)" /protein_id="NP_390742.1" /db_xref="EnsemblGenomes-Gn:BSU28640" /db_xref="EnsemblGenomes-Tr:CAB14824" /db_xref="GOA:P17921" /db_xref="InterPro:IPR002319" /db_xref="InterPro:IPR004188" /db_xref="InterPro:IPR004529" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR010978" /db_xref="InterPro:IPR022911" /db_xref="SubtiList:BG10874" /db_xref="UniProtKB/Swiss-Prot:P17921" /translation="MEEKLKQLEQEALEQVEAASSLKVVNDIRVQYLGKKGPITEVLR GMGKLSAEERPKMGALANEVRERIANAIADKNEKLEEEEMKQKLAGQTIDVTLPGNPV AVGGRHPLTVVIEEIEDLFIGMGYTVEEGPEVETDYYNFESLNLPKEHPARDMQDSFY ITEETLMRTQTSPVQTRTMEKHEGKGPVKIICPGKVYRRDNDDATHSHQFMQIEGLVV DKNISMSDLKGTLELVAKKMFGQDREIRLRPSFFPFTEPSVEVDVTCFKCGGNGCSVC KGTGWIEILGAGMVHPNVLKMAGFDPKEYQGFAFGMGVERIAMLKYGIDDIRHFYTND VRFISQFKQA*" /label="pheS CDS" gene complement(2553762..2554796) /gene="pheS" /locus_tag="BSU_28640" /old_locus_tag="BSU28640" /label="pheS gene" S_feature complement(2554797..2555117) /Source="Nicolas_S_feature" /locus_tag="new_2930473_2930793_c" /HighExp="HPh, Cold, GM 15, GM 10, Sw, C30, G150, MG-0.2, G135, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1081" CDS 2554878..2555084 /locus_tag="BSU_28645" /old_locus_tag="BSU28645" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513995.1" /translation="MWPRYHPYFRQTDAVVSFIDITESDSGSPLRAVYAVPATTQEVK PISGCVKNALSQRHFLPGKQLIRN*" /label="hypothetical protein CDS" gene 2554878..2555084 /locus_tag="BSU_28645" /old_locus_tag="BSU28645" /label="gene" S_feature 2555107..2555371 /Source="Nicolas_S_feature" /locus_tag="new_2930783_2931047" /HighExp="S8, S7, S6, BT, C30, B36, S5, Pyr, C90, Glucon" /AntisenseName="ysgA" /AntisenseCor="-0.23049778674462801" /AntisenseRegPval="-3.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.519" /TUlongSig="NA" /TUlongPSig="NA" /label="S1082" upshifts 2555107 /Source="Nicolas_upshifts" /id="U2215" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.411588411588412" /psig="0.519480519480519" /xcortree=1240 /SigmaFactorBS="ggcattttctccctggaaagcagttgatcagaaattgaggtc ctctgtcacggtttttgaaatattaTGTTCTATTATAGAGaaatccaacgcttggcgc a" /listShort="S1082" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2555112..2555131) /Source="Nicolas_upshift_promotors" /id="U2216" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2133 /SigmaFactorBS="atcctcgtgtatcacttgcgaggatagtGTTGcgccaagcgt tggaTTTCTCTATAATAGAACATAatatttcaaaaaccgtgacagaggacctcaattt c" /listShort="S1081, pheS, pheT" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature 2555114..2555128 /Source="Nicolas_upshift_promotors" /id="U2215" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.411588411588412" /psig="0.519480519480519" /xcortree=1240 /SigmaFactorBS="ggcattttctccctggaaagcagttgatcagaaattgaggtc ctctgtcacggtttttgaaatattaTGTTCTATTATAGAGaaatccaacgcttggcgc a" /listShort="S1082" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2555117) /Source="Nicolas_upshifts" /id="U2216" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2133 /SigmaFactorBS="atcctcgtgtatcacttgcgaggatagtGTTGcgccaagcgt tggaTTTCTCTATAATAGAACATAatatttcaaaaaccgtgacagaggacctcaattt c" /listShort="S1081, pheS, pheT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2555146..2555149) /Source="Nicolas_upshift_promotors" /id="U2216" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2133 /SigmaFactorBS="atcctcgtgtatcacttgcgaggatagtGTTGcgccaagcgt tggaTTTCTCTATAATAGAACATAatatttcaaaaaccgtgacagaggacctcaattt c" /listShort="S1081, pheS, pheT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2555151..2555897) /gene="rlmBB" /locus_tag="BSU_28650" /old_locus_tag="BSU28650" /EC_number="2.1.1.-" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 17114254, 24809820, 27435445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosomal RNA methylase" /protein_id="NP_390743.1" /db_xref="EnsemblGenomes-Gn:BSU28650" /db_xref="EnsemblGenomes-Tr:CAB14825" /db_xref="GOA:P94538" /db_xref="InterPro:IPR001537" /db_xref="InterPro:IPR013123" /db_xref="InterPro:IPR029026" /db_xref="InterPro:IPR029028" /db_xref="InterPro:IPR029064" /db_xref="SubtiList:BG12323" /db_xref="UniProtKB/Swiss-Prot:P94538" /translation="MKQIESAKNQKVKDWKKLHTKKERTKTNTFLIEGEHLVEEALKS PGIVKEILVKDETRIPSDLETGIQCYMLSEDAFSAVTETETPQQIAAVCHMPEEKLAT ARKVLLIDAVQDPGNLGTMIRTADAAGLDAVVLGDGTADAFNGKTLRSAQGSHFHIPV VRRNLPSYVDELKAEGVKVYGTALQNGAPYQEIPQSESFALIVGNEGAGVDAALLEKT DLNLYVPLYGQAESLNVAVAAAILVYHLRG*" /label="rlmBB CDS" gene complement(2555151..2555897) /gene="rlmBB" /locus_tag="BSU_28650" /old_locus_tag="BSU28650" /label="rlmBB gene" promotor_-10 complement(2555924..2555943) /Source="Nicolas_upshift_promotors" /id="U2217" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.436563436563437" /psig=1 /xcortree=2411 /SigmaFactorBS="taaaatgtaatacgtatattctaaccctgcacctGGTTTATt atgtgctgttctTGCGATATAATAACATCATGttaaaaaaaggagcgccacatagaca g" /listShort="ysgA" /listLong="S1081, pheS, pheT" /label="promotor_-10" promotor_-35 2555930..2555936 /Source="Nicolas_upshift_promotors" /id="U2218" /multdbtbs="SigG,SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=944 /SigmaFactorBS="tgtggcgctcctttttttaacatgatGTTATTAtatcgcaag aacaGCACATAATAAAccaggtgcagggttagaatatacgtattacattttagaaaaa g" /listShort="sspI, ysfB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2555937) /Source="Nicolas_upshifts" /id="U2217" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.436563436563437" /psig=1 /xcortree=2411 /SigmaFactorBS="taaaatgtaatacgtatattctaaccctgcacctGGTTTATt atgtgctgttctTGCGATATAATAACATCATGttaaaaaaaggagcgccacatagaca g" /listShort="ysgA" /listLong="S1081, pheS, pheT" /label="upshifts" promotor_-10 2555950..2555961 /Source="Nicolas_upshift_promotors" /id="U2218" /multdbtbs="SigG,SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=944 /SigmaFactorBS="tgtggcgctcctttttttaacatgatGTTATTAtatcgcaag aacaGCACATAATAAAccaggtgcagggttagaatatacgtattacattttagaaaaa g" /listShort="sspI, ysfB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2555957..2555963) /Source="Nicolas_upshift_promotors" /id="U2217" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.436563436563437" /psig=1 /xcortree=2411 /SigmaFactorBS="taaaatgtaatacgtatattctaaccctgcacctGGTTTATt atgtgctgttctTGCGATATAATAACATCATGttaaaaaaaggagcgccacatagaca g" /listShort="ysgA" /listLong="S1081, pheS, pheT" /label="promotor_-35" upshifts 2555964 /Source="Nicolas_upshifts" /id="U2218" /multdbtbs="SigG,SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=944 /SigmaFactorBS="tgtggcgctcctttttttaacatgatGTTATTAtatcgcaag aacaGCACATAATAAAccaggtgcagggttagaatatacgtattacattttagaaaaa g" /listShort="sspI, ysfB" /GFF_Attribute="listLong" /label="upshifts" CDS 2556016..2556231 /gene="sspI" /locus_tag="BSU_28660" /old_locus_tag="BSU28660" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:8171126, 10806362, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8171126, 10806362, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="NP_390744.1" /db_xref="EnsemblGenomes-Gn:BSU28660" /db_xref="EnsemblGenomes-Tr:CAB14826" /db_xref="GOA:P94537" /db_xref="InterPro:IPR017525" /db_xref="SubtiList:BG12318" /db_xref="UniProtKB/Swiss-Prot:P94537" /translation="MDLNLRHAVIANVTGNNQEQLEHTIVDAIQSGEEKMLPGLGVLF EVIWQHASESEKNEMLKTLEGGLKPAE*" /label="sspI CDS" gene 2556016..2556231 /gene="sspI" /locus_tag="BSU_28660" /old_locus_tag="BSU28660" /label="sspI gene" S_feature complement(2556213..2557625) /Source="Nicolas_S_feature" /locus_tag="new_2931889_2933301_c" /HighExp="S6, S8, S7, BT, S5, C30, B36, S4, B60, C90" /AntisenseName="ysfB" /AntisenseCor="0.46970634471519201" /AntisenseRegPval="-15.4" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1083" promotor_-35 2556242..2556249 /Source="Nicolas_upshift_promotors" /id="U2219" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.702297702297702" /psig="0.998001998001998" /xcortree=3149 /SigmaFactorBS="attaaaacccgccgaataagacatgaaacCGGGTGACagcgc ccggttttttTCTTATATAATAAAAACATGatgagggggaacgccatgtttttacagc c" /listShort="ysfB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2556265..2556284 /Source="Nicolas_upshift_promotors" /id="U2219" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.702297702297702" /psig="0.998001998001998" /xcortree=3149 /SigmaFactorBS="attaaaacccgccgaataagacatgaaacCGGGTGACagcgc ccggttttttTCTTATATAATAAAAACATGatgagggggaacgccatgtttttacagc c" /listShort="ysfB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2556273 /Source="Nicolas_upshifts" /id="U2219" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.702297702297702" /psig="0.998001998001998" /xcortree=3149 /SigmaFactorBS="attaaaacccgccgaataagacatgaaacCGGGTGACagcgc ccggttttttTCTTATATAATAAAAACATGatgagggggaacgccatgtttttacagc c" /listShort="ysfB" /GFF_Attribute="listLong" /label="upshifts" CDS 2556300..2557406 /gene="ysfB" /locus_tag="BSU_28670" /old_locus_tag="BSU28670" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (glycolate degradation operon)" /protein_id="NP_390745.2" /db_xref="EnsemblGenomes-Gn:BSU28670" /db_xref="EnsemblGenomes-Tr:CAB14827" /db_xref="InterPro:IPR008599" /db_xref="InterPro:IPR025736" /db_xref="SubtiList:BG12319" /db_xref="UniProtKB/Swiss-Prot:P94536" /translation="MFLQPLLAKKIIAEVKKMYEREVIIVNTDGLIMAGTNDERVGQF HEGALICAKERRSVIITKEDETRLKGVKAGINLPVFFDHDVIAVFGLTGEPAEIQPFG ELLRKMTELFIKESRHLEQSQWRERMLESFMIDWLQLKEWSPSFLEKAQLLGVDLSSR RQMILIQGYEWSPHDIEQMARSWKSSYPADLFIRWGNERILINHEVPQHEQRDRLLRK ILHICSFANTASSQYTAAGAGRAVASSSLTDSYEQAEKALAVSLKRKTPIFEEDLKLD MCLTEISPGTRNEFPQRVLGKALEHQELMNTIRTFFHHDLSLKQTAEDMHIHINTLRY RLAKAEQLTGLRFDRTEDVVTMYVALYFLDQDTK*" /label="ysfB CDS" gene 2556300..2557406 /gene="ysfB" /locus_tag="BSU_28670" /old_locus_tag="BSU28670" /label="ysfB gene" promotor_-35 2557442..2557445 /Source="Nicolas_upshift_promotors" /id="U2220" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.732267732267732" /psig="0.999000999001" /xcortree=2772 /SigmaFactorBS="agagagagtttcagtttcattttttgtatgtttctccATGGa aggctttgctttttTTCTTTTACAATAGATTGAAagcgttttttgacagggggatggg t" /listShort="glcD, glcF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2557461..2557480 /Source="Nicolas_upshift_promotors" /id="U2220" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.732267732267732" /psig="0.999000999001" /xcortree=2772 /SigmaFactorBS="agagagagtttcagtttcattttttgtatgtttctccATGGa aggctttgctttttTTCTTTTACAATAGATTGAAagcgttttttgacagggggatggg t" /listShort="glcD, glcF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2557465 /Source="Nicolas_upshifts" /id="U2220" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.732267732267732" /psig="0.999000999001" /xcortree=2772 /SigmaFactorBS="agagagagtttcagtttcattttttgtatgtttctccATGGa aggctttgctttttTTCTTTTACAATAGATTGAAagcgttttttgacagggggatggg t" /listShort="glcD, glcF" /GFF_Attribute="listLong" /label="upshifts" CDS 2557509..2558921 /gene="glcD" /locus_tag="BSU_28680" /old_locus_tag="BSU28680" /EC_number="1.1.99.14" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8606183, 25217009; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycolate oxidase subunit" /protein_id="NP_390746.1" /db_xref="EnsemblGenomes-Gn:BSU28680" /db_xref="EnsemblGenomes-Tr:CAB14828" /db_xref="GOA:P94535" /db_xref="InterPro:IPR004113" /db_xref="InterPro:IPR004490" /db_xref="InterPro:IPR006094" /db_xref="InterPro:IPR016164" /db_xref="InterPro:IPR016166" /db_xref="InterPro:IPR016167" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR016171" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG12320" /db_xref="UniProtKB/Swiss-Prot:P94535" /translation="MITKDVKEQLIQVSGPENFDDSNAGRLVYSYDATPQYQSMPDAV IAPRNTDEISRILTICSEHRVPIVPRGSGTNLCGGTCPTEGGLVLLFKHMNQILEIDE ENLTATVQPGVITLDMIRAVESKGLFYPPDPSSMKISTIGGNINENSGGLRGLKYGVT RDYVIGLEVVLANGDIIRTGGKLAKDVAGYDLTRLFVGSEGTLGIVTEAIVKLVPKPE TKKTLLALYENIDAAAQTVSDIIAAKIIPATLEFLDQPTLLVIEDYAKIGLPTSAKAV LLIEQDGPFETVERDMEKIEAICKKGDAVSVQTAQTEEEAFALTEARRSALSALARLK PTTILEDATVPRSEIANMVKAINDIAAKYDISICTFGHAGDGNLHPTCTTDIRNKDEM ERVEQAFAEIFEKAIELGGTITGEHGVGEMKAPYLEMKLKKEGIDAMKALKAAFDPRN ILNPGKMFAKDARKRVVAER*" /label="glcD CDS" gene 2557509..2558921 /gene="glcD" /locus_tag="BSU_28680" /old_locus_tag="BSU28680" /label="glcD gene" promotor_-10 complement(2557611..2557630) /Source="Nicolas_upshift_promotors" /id="U2221" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1308 /SigmaFactorBS="aattgttaaaatgcgtgatatttcatcagtattCCTCGGAGC AatcacggcatcaGGCATAGACTGATACTGAGGcgtcgcatcatatgaatagacgaga c" /listShort="S1083" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2557625) /Source="Nicolas_upshifts" /id="U2221" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1308 /SigmaFactorBS="aattgttaaaatgcgtgatatttcatcagtattCCTCGGAGC AatcacggcatcaGGCATAGACTGATACTGAGGcgtcgcatcatatgaatagacgaga c" /listShort="S1083" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2557643..2557652) /Source="Nicolas_upshift_promotors" /id="U2221" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1308 /SigmaFactorBS="aattgttaaaatgcgtgatatttcatcagtattCCTCGGAGC AatcacggcatcaGGCATAGACTGATACTGAGGcgtcgcatcatatgaatagacgaga c" /listShort="S1083" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2558918..2560252 /gene="glcF" /locus_tag="BSU_28690" /old_locus_tag="BSU28690" /EC_number="1.1.99.14" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8606183, 25217009; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycolate oxidase (iron-sulfur subunit)" /protein_id="NP_390747.1" /db_xref="EnsemblGenomes-Gn:BSU28690" /db_xref="EnsemblGenomes-Tr:CAB14829" /db_xref="GOA:P94534" /db_xref="InterPro:IPR004017" /db_xref="InterPro:IPR009051" /db_xref="InterPro:IPR012257" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR017900" /db_xref="SubtiList:BG12321" /db_xref="UniProtKB/Swiss-Prot:P94534" /translation="MTTEKEMKQIQNEFKERMDEGELLNCMRCGFCLPSCPTYIESGF QETHSPRGRIALMKAVADGMIEPDEDVERSLSLCLGCRACEPVCPSGVKYGQLLEEAR DIIHQNKKHSLGERVMRKTAFHELFPHQNRMRSAVSLIGLYQRSGLQTAVRKSGMLRV LPEHLRTMEAVLPDVPKSKDMKHRPRFLPSIGPMKKRVAFFSGCLMDTMFLPTNNATL KLLQLAGCDIVIPPEQACCGALHGHSGEKNTGKELAKQNIAAFEALDVDAVITNAGGC GAFLTEYDHLLKDDPEWSERAAAFVQKLKDFSSVLVELDFHQMDLALETPQVVTYQDS CHLRNVMHTSLEPRQLLKSIKGAEFKEMEKADSCCGSAGIYNIVEVEMSMKILDSKMA AVKATEAILIVTANPGCLLQMKLGIEREGLSGKVRAVHLADLLLEAAGHKTS*" /label="glcF CDS" gene 2558918..2560252 /gene="glcF" /locus_tag="BSU_28690" /old_locus_tag="BSU28690" /label="glcF gene" Polymorphism join(2559951,2559953) /Source="geneious" /ID="SNP_BsDelta6_2935628_2935628" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change /CDS_Position=1035 /Change="C -> T" /Codon_Change="CTC -> CTT" /Coverage=142 /locus_tag="BSU_28690" /Protein_Effect="None" /Reference_Frequency="1.4%" /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=140 /comment="silent" /modified_by="User" / /label="Polymorphism_Delta6" downshifts 2560250 /Source="Nicolas_upshifts" /id="D1468" /incds=0 /nref=48 /ntot=148 /MaxReadThrough="3.07756" /MaxDrop="5.25031" /score="4.55188138" /energy="-14.3" /TU="U2220" /idTUdmin="U2220" /TUdmin="-181" /isTUend="FALSE" /label="downshifts" downshifts complement(2560289) /Source="Nicolas_upshifts" /id="D1469" /incds=0 /nref=27 /ntot=221 /MaxReadThrough="1.51397" /MaxDrop="5.34865" /score="-5.71907967" /energy="-14.3" /TU="NA" /idTUdmin="U2222" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(2560291..2560533) /gene="ysfE" /locus_tag="BSU_28700" /old_locus_tag="BSU28700" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390748.1" /db_xref="EnsemblGenomes-Gn:BSU28700" /db_xref="EnsemblGenomes-Tr:CAB14830" /db_xref="InterPro:IPR025870" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG12322" /db_xref="UniProtKB/Swiss-Prot:P94533" /translation="MALNTRESARDITALDIPDTSASNTFEIGFVTENVEAVIKRMRE QGVSIIGEPKVKPWGQTVAYIADPDGHYIEICSPME*" /label="ysfE CDS" gene complement(2560291..2560533) /gene="ysfE" /locus_tag="BSU_28700" /old_locus_tag="BSU28700" /label="ysfE gene" S_feature complement(2560534..2560705) /Source="Nicolas_S_feature" /locus_tag="new_2936210_2936381_c" /HighExp="Sw, M0t90, M40t90, M9-stat, T2.0H, BC, T0.30H, Lbstat, T2.30H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH, SigA" /TUshortPSig="0.999, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1084" CDS complement(2560593..2560763) /locus_tag="BSU_28709" /old_locus_tag="BSU28709" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513996.1" /translation="MGADVERSELKDGSIYTGLEGLLKMLRGVGNESINEISYSIRIG QQAGYSFFTGIF*" /label="hypothetical protein CDS" gene complement(2560593..2560763) /locus_tag="BSU_28709" /old_locus_tag="BSU28709" /label="gene" CDS complement(2560706..2562502) /gene="cstA" /locus_tag="BSU_28710" /old_locus_tag="BSU28710" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 1848300, 17320232, 19682248" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 1848300, 17320232, 19682248; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="carbon starvation-induced membrane protein" /protein_id="NP_390749.2" /db_xref="EnsemblGenomes-Gn:BSU28710" /db_xref="EnsemblGenomes-Tr:CAB14831" /db_xref="GOA:P94532" /db_xref="InterPro:IPR003706" /db_xref="InterPro:IPR025299" /db_xref="SubtiList:BG11924" /db_xref="UniProtKB/Swiss-Prot:P94532" /translation="MNAVTIVIASMCILAIAYRLYGTFMMVKVLKVNDDKPTPAHALE DGKDYVPTNKWVSFGHHFAAIAAAGPLVGPILAAQFGYLPGLLWLLIGAVIGGAVHDI VVLFASMRKNGKSLSEVAKDELGPVAGFCTGLSMLFIITITMAGLSMVVLHALERNPW GTFAVGITIPIAMGVGLFYKKTGNLKLASTVGFLFLMAGVFIGPWVQTTALGDFLTLD TKTLAIALPVYAFFAAALPVWLLLAPRDYLSSFMKIGVFIALIVGVFVVNPSIPFPAF TEFVKGGGPVLAGPVWPFISITIACGAISGFHAFVGSGTTPKMLNKWSDMKPVAFGAM LVECLVGIMALIAATALQPADYFAINSTPEVFRTLGMNVVHLPELSGEIGLDLEGRTG GAVTLAVGMTYIFTGMPFFSHLASYFFQFVIMFEAVFILTAIDAGTRVARYLIQDFFG EVYKPLKKTDWIPGSVFASALACLMWGYLLYSGDIGSIWALFGVSNQLMASVGLIIGA TIVLKIADKRRYILTCLIPLAYLYVTVNYAGYWMVRNVYLNPEAAGYSVLNGVLSIIM LVLGFIIIVAAVKKWAQMWKDPSLRMEASIPG*" /label="cstA CDS" gene complement(2560706..2562502) /gene="cstA" /locus_tag="BSU_28710" /old_locus_tag="BSU28710" /label="cstA gene" promotor_-10 complement(2560808..2560826) /Source="Nicolas_upshift_promotors" /id="U2222" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3197 /SigmaFactorBS="ctattggatggtgcgcaatgtgtatctcaatcctgaagcaGC AGGATATagtgtattgaaTGGCGTATTATCTATCATCatgctggtgttaggcttcatc a" /listShort="S1084, ysfE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2560826) /Source="Nicolas_upshifts" /id="U2222" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3197 /SigmaFactorBS="ctattggatggtgcgcaatgtgtatctcaatcctgaagcaGC AGGATATagtgtattgaaTGGCGTATTATCTATCATCatgctggtgttaggcttcatc a" /listShort="S1084, ysfE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2560838..2560846) /Source="Nicolas_upshift_promotors" /id="U2222" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3197 /SigmaFactorBS="ctattggatggtgcgcaatgtgtatctcaatcctgaagcaGC AGGATATagtgtattgaaTGGCGTATTATCTATCATCatgctggtgttaggcttcatc a" /listShort="S1084, ysfE" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2562499 /Source="Nicolas_upshifts" /id="D1470" /incds=0 /nref=4 /ntot=49 /MaxReadThrough="0.92122" /MaxDrop="3.18629" /score="12.2066828" /energy="-15.2" /TU="NA" /idTUdmin="U2220" /TUdmin=2068 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2562527..2562546) /Source="Nicolas_upshift_promotors" /id="U2223" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.511488511488511" /psig="0.999000999001" /xcortree=369 /SigmaFactorBS="ccattccagccggctttttgtataggaaaaAATGACCgcttt tcaccatgaAATTATGATATATTTATGAAaaacagaaaaggggatgggagaaaatgaa t" /listShort="cstA, S1084, ysfE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2562537) /Source="Nicolas_upshifts" /id="U2223" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.511488511488511" /psig="0.999000999001" /xcortree=369 /SigmaFactorBS="ccattccagccggctttttgtataggaaaaAATGACCgcttt tcaccatgaAATTATGATATATTTATGAAaaacagaaaaggggatgggagaaaatgaa t" /listShort="cstA, S1084, ysfE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2562561..2562567) /Source="Nicolas_upshift_promotors" /id="U2223" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.511488511488511" /psig="0.999000999001" /xcortree=369 /SigmaFactorBS="ccattccagccggctttttgtataggaaaaAATGACCgcttt tcaccatgaAATTATGATATATTTATGAAaaacagaaaaggggatgggagaaaatgaa t" /listShort="cstA, S1084, ysfE" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2562597..2562653) /Source="Nicolas_S_feature" /locus_tag="new_2938273_2938329_c" /HighExp="BC, Sw, M40t90, T1.30H, M0t90, T1.0H, T0.30H, Lbstat, T2.30H, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1085" downshifts complement(2562621) /Source="Nicolas_upshifts" /id="D1471" /incds=0 /nref=12 /ntot=40 /MaxReadThrough="0.655710000000001" /MaxDrop="5.03461" /score="9.68754272" /energy="-10.5" /TU="NA" /idTUdmin="U2224" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(2562654..2564156) /gene="abfA" /locus_tag="BSU_28720" /old_locus_tag="BSU28720" /EC_number="3.2.1.55" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10417639, 11418559, 12777810, 14973026, 16233670, 18757805" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10417639, 11418559, 12777810, 14973026, 16233670, 18757805; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="alpha-L-arabinofuranosidase" /protein_id="NP_390750.2" /db_xref="EnsemblGenomes-Gn:BSU28720" /db_xref="EnsemblGenomes-Tr:CAB14832" /db_xref="GOA:P94531" /db_xref="InterPro:IPR010720" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG11900" /db_xref="UniProtKB/Swiss-Prot:P94531" /translation="MKKARMIVDKEYKIGEVDKRIYGSFIEHMGRAVYEGIYEPDHPE ADEDGFRKDVQSLIKELQVPIIRYPGGNFLSGYNWEDGVGPVENRPRRLDLAWQTTET NEVGTNEFLSWAKKVNTEVNMAVNLGTRGIDAARNLVEYCNHPKGSYWSDLRRSHGYE QPYGIKTWCLGNEMDGPWQIGHKTADEYGRLAAETAKVMKWVDPSIELVACGSSNSGM PTFIDWEAKVLEHTYEHVDYISLHTYYGNRDNNLPNYLARSMDLDHFIKSVAATCDYV KAKTRSKKTINLSLDEWNVWYHSNEADKKVEPWITARPILEDIYNFEDALLVGSLLIT MLQHADRVKIACLAQLVNVIAPIMTEKGGEAWRQPIFYPYMHASVYGRGESLKPLISS PKYDCSDFTDVPYVDAAVVYSEEEETLTIFAVNKAEDQMETEISLRGFESYQIAEHIV LEHQDIKATNQHNRKNVVPHSNGSSSVSENGLTAHFTPLSWNVIRLKKQS*" /label="abfA CDS" gene complement(2562654..2564156) /gene="abfA" /locus_tag="BSU_28720" /old_locus_tag="BSU28720" /label="abfA gene" downshifts complement(2564027) /Source="Nicolas_upshifts" /id="D1472" /incds=1 /nref=7 /ntot=15 /MaxReadThrough="3.81491" /MaxDrop="6.33773" /score="2.73497974" /energy="-14.2" /TU="U2224,U2225" /idTUdmin="U2224" /TUdmin="-1408" /isTUend="FALSE" /label="downshifts" promotor_no_box complement(2564131..2564231) /Source="Nicolas_upshift_promotors" /id="U2224" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.608391608391608" /psig="0.017982017982018" /xcortree=1474 /SigmaFactorBS="ttgtttttccaaaagtactttatctccggcctgacggtaggg ggagtcaaaggttaatgaaggaggaaacgtgtgatgaaaaaagcgcgaatgattgtag a" /listShort="abfA" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(2564171) /Source="Nicolas_upshifts" /id="U2224" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.608391608391608" /psig="0.017982017982018" /xcortree=1474 /SigmaFactorBS="ttgtttttccaaaagtactttatctccggcctgacggtaggg ggagtcaaaggttaatgaaggaggaaacgtgtgatgaaaaaagcgcgaatgattgtag a" /listShort="abfA" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2564175..2565020) /gene="araQ" /locus_tag="BSU_28730" /old_locus_tag="BSU28730" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9084180, 10417639, 11418559, 14973026, 15849754, 16850406, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9084180, 10417639, 11418559, 14973026, 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="arabinose/arabinan permease" /protein_id="NP_390751.2" /db_xref="EnsemblGenomes-Gn:BSU28730" /db_xref="EnsemblGenomes-Tr:CAB14833" /db_xref="GOA:P94530" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11912" /db_xref="UniProtKB/Swiss-Prot:P94530" /translation="MLRHSPQFSVYRIALTLFFMMLSLLYLFPIFCLLLGSLKPSSEL LRVGLNLDIDPKVMSFDNYTFLFNGGSIYFKWFFNSLVLGLFTTVLTLFFSSMIGYGL AVYDFKGRNIIFVLVLIIMMVPLEVMMLPLFKLTVGLHLIDSYTGVILPFIVSPVAVF FFRQYALGLPRDLLDSARMDGCTEFGIFFRIMAPLMKPAFGAMIILQSLNSWNNFLWP LIVLRSKEMFTLPIGLSSLLSPYGNNYDMLISGSVFAILPVIIIFLFFQKYFISGLTV GGVKG*" /label="araQ CDS" gene complement(2564175..2565020) /gene="araQ" /locus_tag="BSU_28730" /old_locus_tag="BSU28730" /label="araQ gene" CDS complement(2565021..2565962) /gene="araP" /locus_tag="BSU_28740" /old_locus_tag="BSU28740" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9084180, 10417639, 11418559, 14973026, 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="arabinose/arabinan permease" /protein_id="NP_390752.1" /db_xref="EnsemblGenomes-Gn:BSU28740" /db_xref="EnsemblGenomes-Tr:CAB14834" /db_xref="GOA:P94529" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035277" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11911" /db_xref="UniProtKB/Swiss-Prot:P94529" /translation="MKPVKTGTVHPVPSAAKQSGWRDLFYSKKAAPYLFTAPFVLSFL VFFLYPIISVFIMSFQRILPGEVSFVGLSNYTALNNPTFYTALWNTLEYTFWTLIVLI PVPLLLAIFLNSKLVKFRNIFKSALFIPALTSTIVAGIIFRLIFGEMETSLANSILLK LGFSPQNWMNNEHTGMFLMVLLASWRWMGINILYFLAGLQNVPKELYEAADIDGANTM KKFLHITLPFLKPVTVYVLTISIIGGFRMFEESYVLWQNNSPGNIGLTLVGYLYQQGL AYNEMGYGAAIGIVLLIVILVVSLISLKLSGSFKGEG*" /label="araP CDS" gene complement(2565021..2565962) /gene="araP" /locus_tag="BSU_28740" /old_locus_tag="BSU28740" /label="araP gene" CDS complement(2565998..2567299) /gene="araN" /locus_tag="BSU_28750" /old_locus_tag="BSU28750" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9084180, 10417639, 11418559, 14973026, 15849754, 16850406, 22720735; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="sugar-binding lipoprotein" /protein_id="NP_390753.2" /db_xref="EnsemblGenomes-Gn:BSU28750" /db_xref="EnsemblGenomes-Tr:CAB14835" /db_xref="GOA:P94528" /db_xref="InterPro:IPR006059" /db_xref="SubtiList:BG11910" /db_xref="UniProtKB/Swiss-Prot:P94528" /translation="MKKMTVCFLVLMMLLTLVIAGCSAEKSSGKSGETELTFWTFNGL HEQFYVEMVKEWNKKYPDRKIKLNTVVYPYGQMHDNLSISLIAGEGVPDIADVELARF SNFLKGSDIPLADLTPLIEKDRDKFVEARLTLYSKNGKLYGLDTHVGTTVMFYNMDVM KKAGVNPDDIKTWDDYHKAGQKVRKVTGKPMGTVETNDSATFLSMISQQNSGYFDKNG KLILNNDTNVKTLQYLKDMINDKTMIPAPGGGHHSEEYYGFMNQGGAASVLMPIWYMG RFIDYMPDLKGKIAIRPLPAWKEGGDRSAGLGGTATVVPKQSKHVELAKEFLAFAKGS EEGNKKLWSVLGFDPLRWDVWSSKELKEKNKYTDYFQNGTGIFSVLLDIKDEINPIYL HEDFAKASDLVNRSVLFDALKSQQKTPKQALDRAAGELKQK*" /label="araN CDS" gene complement(2565998..2567299) /gene="araN" /locus_tag="BSU_28750" /old_locus_tag="BSU28750" /label="araN gene" CDS complement(2567330..2568514) /gene="egsA" /locus_tag="BSU_28760" /old_locus_tag="BSU28760" /EC_number="1.1.1.261" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9084180, 9973362, 10417639, 11418559, 14973026, 18558723, 22720735, 27774041" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9084180, 9973362, 10417639, 11418559, 14973026, 18558723, 22720735, 27774041; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sn-glycerol-1-phosphate dehydrogenase [NAD+] (catabolic)" /protein_id="NP_390754.1" /db_xref="EnsemblGenomes-Gn:BSU28760" /db_xref="EnsemblGenomes-Tr:CAB14836" /db_xref="GOA:P94527" /db_xref="InterPro:IPR023003" /db_xref="InterPro:IPR032837" /db_xref="SubtiList:BG11909" /db_xref="UniProtKB/Swiss-Prot:P94527" /translation="MNRIAADVQRAFENAGEKTLPIKVEEIVLGKQAADSLLDYVKRK NNQHIVLVCDANTHRIAGIDLENRLNQEGFQAECLIIPENEAGDVTADERSLIHVLIH TKQPTDVMIAVGSGTIHDIVRFAAFQRDLPFISYPTAPSVDGFTSAGAPIILYGTKTT IQTKAPSALFADLDLLKAAPQSMVAAGFGDMLGKITSLADWEISRHLAGEPYSPAGAK IVQEALAACIEHTEDIAMKTETGIRVLMESLLVSGLVMLALDHSRPASGGEHHISHWI EMELMEKKRPQILHGAKVGCAAVLLTDTYRKLAQDDGLNEFSPSRREAIQSAYQTLPR GEVLADWLRSAGGPAYFDEIGVGQDSVKNAFRHAHTLRDRCTGLRIINENKTLINHGL YE*" /label="egsA CDS" gene complement(2567330..2568514) /gene="egsA" /locus_tag="BSU_28760" /old_locus_tag="BSU28760" /label="egsA gene" CDS complement(2568511..2569329) /gene="araL" /locus_tag="BSU_28770" /old_locus_tag="BSU28770" /EC_number="3.1.3.23" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10417639, 11418559, 14973026, 21575135, 22720735, 25848029" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10417639, 11418559, 14973026, 21575135, 22720735, 25848029; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="glycolytic and pentose phosphate intermediates phosphatase" /protein_id="NP_390755.1" /db_xref="EnsemblGenomes-Gn:BSU28770" /db_xref="EnsemblGenomes-Tr:CAB14837" /db_xref="GOA:P94526" /db_xref="InterPro:IPR006357" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG11908" /db_xref="UniProtKB/Swiss-Prot:P94526" /translation="MRIMASHDTPVSPAGILIDLDGTVFRGNELIEGAREAIKTLRRM GKKIVFLSNRGNISRAMCRKKLLGAGIETDVNDIVLSSSVTAAFLKKHYRFSKVWVLG EQGLVDELRLAGVQNASEPKEADWLVISLHETLTYDDLNQAFQAAAGGARIIATNKDR SFPNEDGNAIDVAGMIGAIETSAQAKTELVVGKPSWLMAEAACTAMGLSAHECMIIGD SIESDIAMGKLYGMKSALVLTGSAKQGEQRLYTPDYVLDSIKDVTKLAEEGILI*" /label="araL CDS" gene complement(2568511..2569329) /gene="araL" /locus_tag="BSU_28770" /old_locus_tag="BSU28770" /label="araL gene" CDS complement(2569307..2569996) /gene="araD" /locus_tag="BSU_28780" /old_locus_tag="BSU28780" /EC_number="5.1.3.4" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10417639, 11418559, 11732895, 14973026, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-ribulose-5-phosphate 4-epimerase" /protein_id="NP_390756.1" /db_xref="EnsemblGenomes-Gn:BSU28780" /db_xref="EnsemblGenomes-Tr:CAB14838" /db_xref="GOA:P94525" /db_xref="InterPro:IPR001303" /db_xref="InterPro:IPR004661" /db_xref="InterPro:IPR036409" /db_xref="SubtiList:BG11906" /db_xref="UniProtKB/Swiss-Prot:P94525" /translation="MLETLKKEVLAANLKLQEHQLVTFTWGNVSGIDREKERIVIKPS GVEYSDLTADDLVVLNLDGEVVEGSLKPSSDTPTHVYLYKAFPNIGGIVHTHSQWATS WAQSGRDIPPLGTTHADYFDSAIPCTREMYDEEIIHDYELNTGKVIAETFQHHNYEQV PGVLVNNHGPFCWGTDALNAIHNAVVLETVAEMAYHSIMLNKDVTPINTVLHEKHFYR KHGANAYYGQS*" /label="araD CDS" gene complement(2569307..2569996) /gene="araD" /locus_tag="BSU_28780" /old_locus_tag="BSU28780" /label="araD gene" CDS complement(2570013..2571695) /gene="araB" /locus_tag="BSU_28790" /old_locus_tag="BSU28790" /EC_number="2.7.1.16" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 173711, 4910050, 10417639, 11418559, 14973026, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-ribulokinase" /protein_id="NP_390757.1" /db_xref="EnsemblGenomes-Gn:BSU28790" /db_xref="EnsemblGenomes-Tr:CAB14839" /db_xref="GOA:P94524" /db_xref="InterPro:IPR000577" /db_xref="InterPro:IPR005929" /db_xref="InterPro:IPR018483" /db_xref="InterPro:IPR018484" /db_xref="InterPro:IPR018485" /db_xref="SubtiList:BG11905" /db_xref="UniProtKB/Swiss-Prot:P94524" /translation="MAYTIGVDFGTLSGRAVLVHVQTGEELAAAVKEYRHAVIDTVLP KTGQKLPRDWALQHPADYLEVLETTIPSLLEQTGVDPKDIIGIGIDFTACTILPIDSS GQPLCMLPEYEEEPHSYVKLWKHHAAQKHADRLNQIAEEEGEAFLQRYGGKISSEWMI PKVMQIAEEAPHIYEAADRIIEAADWIVYQLCGSLKRSNCTAGYKAMWSEKAGYPSDD FFEKLNPSMKTITKDKLSGSIHSVGEKAGSLTEKMAKLTGLLPGTAVAVANVDAHVSV PAVGITEPGKMLMIMGTSTCHVLLGEEVHIVPGMCGVVDNGILPGYAGYEAGQSCVGD HFDWFVKTCVPPAYQEEAKEKNIGVHELLSEKANHQAPGESGLLALDWWNGNRSTLVD ADLTGMLLGMTLLTKPEEIYRALVEATAYGTRMIIETFKESGVPIEELFAAGGIAEKN PFVMQIYADVTNMDIKISGSPQAPALGSAIFGALAAGKEKGGYDDIKKAAANMGKLKD ITYTPNAENAAVYEKLYAEYKELVHYFGKENHVMKRLKTIKNLQFSSAAKKN*" /label="araB CDS" gene complement(2570013..2571695) /gene="araB" /locus_tag="BSU_28790" /old_locus_tag="BSU28790" /label="araB gene" CDS complement(2571709..2573199) /gene="araA" /locus_tag="BSU_28800" /old_locus_tag="BSU28800" /EC_number="5.3.1.4" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10417639, 10669396, 11418559, 14973026, 18263741" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10417639, 10669396, 11418559, 14973026, 18263741; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-arabinose isomerase" /protein_id="NP_390758.2" /db_xref="EnsemblGenomes-Gn:BSU28800" /db_xref="EnsemblGenomes-Tr:CAB14840" /db_xref="GOA:P94523" /db_xref="InterPro:IPR003762" /db_xref="InterPro:IPR004216" /db_xref="InterPro:IPR009015" /db_xref="InterPro:IPR024664" /db_xref="SubtiList:BG11904" /db_xref="UniProtKB/Swiss-Prot:P94523" /translation="MLQTKDYEFWFVTGSQHLYGEETLELVDQHAKSICEGLSGISSR YKITHKPVVTSPETIRELLREAEYSETCAGIITWMHTFSPAKMWIEGLSSYQKPLMHL HTQYNRDIPWGTIDMDFMNSNQSAHGDREYGYINSRMGLSRKVIAGYWDDEEVKKEMS QWMDTAAALNESRHIKVARFGDNMRHVAVTDGDKVGAHIQFGWQVDGYGIGDLVEVMD RITDDEVDTLYAEYDRLYVISEETKRDEAKVASIKEQAKIELGLTAFLEQGGYTAFTT SFEVLHGMKQLPGLAVQRLMEKGYGFAGEGDWKTAALVRMMKIMAKGKRTSFMEDYTY HFEPGNEMILGSHMLEVCPTVALDQPKIEVHSLSIGGKEDPARLVFNGISGSAIQASI VDIGGRFRLVLNEVNGQEIEKDMPNLPVARVLWKPEPSLKTAAEAWILAGGAHHTCLS YELTAEQMLDWAEMAGIESVLISRDTTIHKLKHELKWNEALYRLQK*" /label="araA CDS" gene complement(2571709..2573199) /gene="araA" /locus_tag="BSU_28800" /old_locus_tag="BSU28800" /label="araA gene" promotor_-10 complement(2573292..2573311) /Source="Nicolas_upshift_promotors" /id="U2225" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.978021978021978" /psig=1 /xcortree=1574 /SigmaFactorBS="tgcccccggctttttttaaaagaaaaGATTGACAgtataata gtcaatTACTATAATAAAATTGTTCGtacaaatatttatttataggtttattttctat c" /listShort="araA, araB, araD, araL, araM, araN, araP, araQ, abfA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2573299) /Source="Nicolas_upshifts" /id="U2225" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.978021978021978" /psig=1 /xcortree=1574 /SigmaFactorBS="tgcccccggctttttttaaaagaaaaGATTGACAgtataata gtcaatTACTATAATAAAATTGTTCGtacaaatatttatttataggtttattttctat c" /listShort="araA, araB, araD, araL, araM, araN, araP, araQ, abfA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2573301..2573376) /Source="Nicolas_S_feature" /locus_tag="new_2948977_2949052_c" /HighExp="M9-stat, T1.30H, T2.0H, T2.30H, T3.0H, T4.0H, T3.30H, T1.0H, BC, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="SigA" /TUlongPSig="0.993" /label="S1086" promotor_-35 complement(2573326..2573333) /Source="Nicolas_upshift_promotors" /id="U2225" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.978021978021978" /psig=1 /xcortree=1574 /SigmaFactorBS="tgcccccggctttttttaaaagaaaaGATTGACAgtataata gtcaatTACTATAATAAAATTGTTCGtacaaatatttatttataggtttattttctat c" /listShort="araA, araB, araD, araL, araM, araN, araP, araQ, abfA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2573377..2574348) /gene="abnA" /locus_tag="BSU_28810" /old_locus_tag="BSU28810" /EC_number="3.2.1.99" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14973026, 15556708, 17827291, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14973026, 15556708, 17827291, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arabinan-endo-1,5-alpha-L-arabinase" /protein_id="NP_390759.2" /db_xref="EnsemblGenomes-Gn:BSU28810" /db_xref="EnsemblGenomes-Tr:CAB14841" /db_xref="GOA:P94522" /db_xref="InterPro:IPR006710" /db_xref="InterPro:IPR016840" /db_xref="InterPro:IPR023296" /db_xref="PDB:1UV4" /db_xref="SubtiList:BG11901" /db_xref="UniProtKB/Swiss-Prot:P94522" /translation="MKKKKTWKRFLHFSSAALAAGLIFTSAAPAEAAFWGASNELLHD PTMIKEGSSWYALGTGLTEERGLRVLKSSDAKNWTVQKSIFTTPLSWWSNYVPNYGQN QWAPDIQYYNGKYWLYYSVSSFGSNTSAIGLASSTSISSGGWKDEGLVIRSTSSNNYN AIDPELTFDKDGNPWLAFGSFWSGIKLTKLDKSTMKPTGSLYSIAARPNNGGALEAPT LTYQNGYYYLMVSFDKCCDGVNSTYKIAYGRSKSITGPYLDKSGKSMLEGGGTILDSG NDQWKGPGGQDIVNGNILVRHAYDANDNGIPKLLINDLNWSSGWPSY*" /label="abnA CDS" gene complement(2573377..2574348) /gene="abnA" /locus_tag="BSU_28810" /old_locus_tag="BSU28810" /label="abnA gene" S_feature complement(2574349..2574477) /Source="Nicolas_S_feature" /locus_tag="new_2950025_2950153_c" /HighExp="M9-stat, BC, T2.0H, T2.30H, T3.0H, S8, T1.30H, T3.30H, M0t90, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="SigA" /TUlongPSig="0.993" /label="S1087" promotor_-10 complement(2574462..2574481) /Source="Nicolas_upshift_promotors" /id="U2226" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.504495504495505" /psig="0.995004995004995" /xcortree=359 /SigmaFactorBS="gaagaatccgcctattgaggtggattctatttttttgtCTGT acaaattacagcatAGTGACTACAATAAAGGGGAtaccgaaaatttcctgaacatgac g" /listShort="S1087, abnA, S1086, araA, araB, araD, araL, araM, araN" /listLong="araP, araQ, abfA" /label="promotor_-10" upshifts complement(2574477) /Source="Nicolas_upshifts" /id="U2226" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.504495504495505" /psig="0.995004995004995" /xcortree=359 /SigmaFactorBS="gaagaatccgcctattgaggtggattctatttttttgtCTGT acaaattacagcatAGTGACTACAATAAAGGGGAtaccgaaaatttcctgaacatgac g" /listShort="S1087, abnA, S1086, araA, araB, araD, araL, araM, araN" /listLong="araP, araQ, abfA" /label="upshifts" promotor_-35 complement(2574496..2574499) /Source="Nicolas_upshift_promotors" /id="U2226" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.504495504495505" /psig="0.995004995004995" /xcortree=359 /SigmaFactorBS="gaagaatccgcctattgaggtggattctatttttttgtCTGT acaaattacagcatAGTGACTACAATAAAGGGGAtaccgaaaatttcctgaacatgac g" /listShort="S1087, abnA, S1086, araA, araB, araD, araL, araM, araN" /listLong="araP, araQ, abfA" /label="promotor_-35" CDS complement(2574545..2575630) /gene="frvX" /locus_tag="BSU_28820" /old_locus_tag="BSU28820" /EC_number="3.4.11.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15375159, 16021622; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative fructose-lysine aminopeptidase" /protein_id="NP_390760.1" /db_xref="EnsemblGenomes-Gn:BSU28820" /db_xref="EnsemblGenomes-Tr:CAB14842" /db_xref="GOA:P94521" /db_xref="InterPro:IPR008007" /db_xref="InterPro:IPR023367" /db_xref="PDB:1VHE" /db_xref="SubtiList:BG12317" /db_xref="UniProtKB/Swiss-Prot:P94521" /translation="MAKLDETLTMLKDLTDAKGIPGNEREVRQVMKSYIEPFADEVTT DRLGSLIAKKTGAENGPKIMIAGHLDEVGFMVTQITDKGFIRFQTVGGWWAQVMLAQR VTIVTKKGEITGVIGSKPPHILSPEARKKSVEIKDMFIDIGASSREEALEWGVLPGDM IVPHFEFTVMNNEKFLLAKAWDNRIGCAIAIDVLRNLQNTDHPNIVYGVGTVQEEVGL RGAKTAAHTIQPDIAFGVDVGIAGDTPGISEKEAQSKMGKGPQIIVYDASMVSHKGLR DAVVATAEEAGIPYQFDAIAGGGTDSGAIHLTANGVPALSITIATRYIHTHAAMLHRD DYENAVKLITEVIKKLDRKTVDEITYQ*" /label="frvX CDS" gene complement(2574545..2575630) /gene="frvX" /locus_tag="BSU_28820" /old_locus_tag="BSU28820" /label="frvX gene" downshifts complement(2574559) /Source="Nicolas_upshifts" /id="D1473" /incds=0 /nref=233 /ntot=262 /MaxReadThrough="3.55686" /MaxDrop="6.91328" /score="-0.475558157" /energy="-9.9" /TU="U2227" /idTUdmin="U2227" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2575656..2575675) /Source="Nicolas_upshift_promotors" /id="U2227" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.97902097902098" /psig="0.993006993006993" /xcortree=2217 /SigmaFactorBS="aaaagaaagctgtaaaaacatatacccgattttcaagtgaaa TAGTCGTAtggttagcgccatgTTTTGTATAATAAGAATGCAggactgatgaaggagg g" /listShort="ysdC" /listLong="S1087, abnA, S1086, araA, araB, araD, araL, araM, araN, araP, araQ, abfA" /label="promotor_-10" upshifts complement(2575679) /Source="Nicolas_upshifts" /id="U2227" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.97902097902098" /psig="0.993006993006993" /xcortree=2217 /SigmaFactorBS="aaaagaaagctgtaaaaacatatacccgattttcaagtgaaa TAGTCGTAtggttagcgccatgTTTTGTATAATAAGAATGCAggactgatgaaggagg g" /listShort="ysdC" /listLong="S1087, abnA, S1086, araA, araB, araD, araL, araM, araN, araP, araQ, abfA" /label="upshifts" promotor_-35 complement(2575690..2575697) /Source="Nicolas_upshift_promotors" /id="U2227" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.97902097902098" /psig="0.993006993006993" /xcortree=2217 /SigmaFactorBS="aaaagaaagctgtaaaaacatatacccgattttcaagtgaaa TAGTCGTAtggttagcgccatgTTTTGTATAATAAGAATGCAggactgatgaaggagg g" /listShort="ysdC" /listLong="S1087, abnA, S1086, araA, araB, araD, araL, araM, araN, araP, araQ, abfA" /label="promotor_-35" promotor_-35 2575748..2575757 /Source="Nicolas_upshift_promotors" /id="U2228" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1686 /SigmaFactorBS="cttgaaaatcgggtatatgtttttacagctttcttttagaaa aagTGAAACCTTTttctatgctttTCGTATTACATCAGATcatcaccataagggaggt g" /listShort="ysdB, S1088, yscB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2575763 /Source="Nicolas_upshifts" /id="U2228" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1686 /SigmaFactorBS="cttgaaaatcgggtatatgtttttacagctttcttttagaaa aagTGAAACCTTTttctatgctttTCGTATTACATCAGATcatcaccataagggaggt g" /listShort="ysdB, S1088, yscB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2575769..2575784 /Source="Nicolas_upshift_promotors" /id="U2228" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1686 /SigmaFactorBS="cttgaaaatcgggtatatgtttttacagctttcttttagaaa aagTGAAACCTTTttctatgctttTCGTATTACATCAGATcatcaccataagggaggt g" /listShort="ysdB, S1088, yscB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2575814..2576206 /gene="ysdB" /locus_tag="BSU_28830" /old_locus_tag="BSU28830" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 10960106, 23155385" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390761.1" /db_xref="EnsemblGenomes-Gn:BSU28830" /db_xref="EnsemblGenomes-Tr:CAB14843" /db_xref="GOA:P94520" /db_xref="SubtiList:BG12316" /db_xref="UniProtKB/Swiss-Prot:P94520" /translation="MFVMVLRIILLALFAYCIYAVVKYVANPKRRLKLAQSKEHFYII DEQNNTRKNFQLTYKGVLFEGEKHIPSKDHPLFIHTIFVWTESPEKLKHFSAKDFENI EEKVLERYPNCKIDWDQPIKLAKKAEER*" /label="ysdB CDS" gene 2575814..2576206 /gene="ysdB" /locus_tag="BSU_28830" /old_locus_tag="BSU28830" /label="ysdB gene" downshifts 2576177 /Source="Nicolas_upshifts" /id="D1474" /incds=0 /nref=86 /ntot=229 /MaxReadThrough="5.09744" /MaxDrop="4.57118" /score="13.4996084" /energy="-15.8" /TU="U2228" /idTUdmin="U2228" /TUdmin="-2112" /isTUend="FALSE" /label="downshifts" S_feature 2576222..2576528 /Source="Nicolas_S_feature" /locus_tag="new_2951898_2952204" /HighExp="Etha, M9-stat, T0.30H, T1.30H, T1.0H, T2.0H, T2.30H, S8, T3.30H, Salt" /AntisenseName="ysdA" /AntisenseCor="-0.31305612685159701" /AntisenseRegPval="-6.8" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1088" CDS complement(2576222..2576491) /gene="ysdA" /locus_tag="BSU_28840" /old_locus_tag="BSU28840" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17289755; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane component" /protein_id="NP_390762.1" /db_xref="EnsemblGenomes-Gn:BSU28840" /db_xref="EnsemblGenomes-Tr:CAB14844" /db_xref="GOA:P94519" /db_xref="InterPro:IPR010718" /db_xref="SubtiList:BG12315" /db_xref="UniProtKB/Swiss-Prot:P94519" /translation="MIIAAYLVLINLCGFWVMGIDKRKAQQHKWRISEDRLWLIAIVF GALGVWLGMQTFRHKTKHASFKYGVPLLLVIEAILIAIYYSPFDL*" /label="ysdA CDS" gene complement(2576222..2576491) /gene="ysdA" /locus_tag="BSU_28840" /old_locus_tag="BSU28840" /label="ysdA gene" downshifts complement(2576238) /Source="Nicolas_upshifts" /id="D1475" /incds=0 /nref=6 /ntot=206 /MaxReadThrough="2.53274" /MaxDrop="3.80421" /score="20.1281719" /energy="-14" /TU="U2229" /idTUdmin="U2230" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" downshifts complement(2576407) /Source="Nicolas_upshifts" /id="D1476" /incds=1 /nref=1 /ntot=37 /MaxReadThrough="4.90568" /MaxDrop="2.19601" /score="25.5196116" /energy="-14.1" /TU="U2229,U2230" /idTUdmin="U2230" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" downshifts 2576485 /Source="Nicolas_upshifts" /id="D1477" /incds=0 /nref=8 /ntot=135 /MaxReadThrough="4.08794" /MaxDrop="3.37039" /score="13.4996084" /energy="-15.8" /TU="U2228" /idTUdmin="U2228" /TUdmin="-1804" /isTUend="FALSE" /label="downshifts" CDS complement(2576548..2576907) /gene="rplT" /locus_tag="BSU_28850" /old_locus_tag="BSU28850" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12682299, 17289755, 21843271, 23611891" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17289755, 21843271, 23611891; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L20" /protein_id="NP_390763.1" /db_xref="EnsemblGenomes-Gn:BSU28850" /db_xref="EnsemblGenomes-Tr:CAB14845" /db_xref="GOA:P55873" /db_xref="InterPro:IPR005813" /db_xref="InterPro:IPR035566" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11971" /db_xref="UniProtKB/Swiss-Prot:P55873" /translation="MPRVKGGTVTRKRRKKVLKLAKGYFGSKHTLYKVANQQVMKSGN YAFRDRRQKKRDFRKLWITRINAAARMNGLSYSRLMHGLKLSGIEVNRKMLADLAVND LTAFNQLADAAKAQLNK*" /label="rplT CDS" gene complement(2576548..2576907) /gene="rplT" /locus_tag="BSU_28850" /old_locus_tag="BSU28850" /label="rplT gene" downshifts complement(2576561) /Source="Nicolas_upshifts" /id="D1478" /incds=0 /nref=260 /ntot=268 /MaxReadThrough="5.94351" /MaxDrop="6.27682" /score="25.5196116" /energy="-14.1" /TU="U2229,U2230" /idTUdmin="U2230" /TUdmin="-330" /isTUend="FALSE" /label="downshifts" CDS complement(2576939..2577139) /gene="rpmI" /locus_tag="BSU_28860" /old_locus_tag="BSU28860" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8722036, 12682299, 17289755, 21843271, 23002217, 23611891, 24335279" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8722036, 12682299, 17289755, 21843271, 23002217, 23611891, 24335279; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L35" /protein_id="NP_390764.1" /db_xref="EnsemblGenomes-Gn:BSU28860" /db_xref="EnsemblGenomes-Tr:CAB14846" /db_xref="GOA:P55874" /db_xref="InterPro:IPR001706" /db_xref="InterPro:IPR018265" /db_xref="InterPro:IPR021137" /db_xref="InterPro:IPR037229" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11972" /db_xref="UniProtKB/Swiss-Prot:P55874" /translation="MPKMKTHRGSAKRFKKTGSGKLKRSHAYTSHLFANKSQKQKRKL RKSAVVSAGDFKRIKQMLANIK*" /label="rpmI CDS" gene complement(2576939..2577139) /gene="rpmI" /locus_tag="BSU_28860" /old_locus_tag="BSU28860" /label="rpmI gene" CDS complement(2577152..2577673) /gene="infC" /locus_tag="BSU_28870" /old_locus_tag="BSU28870" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 17289755, 21843271, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17289755, 21843271, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="initiation factor IF-3" /protein_id="NP_390765.1" /db_xref="EnsemblGenomes-Gn:BSU28870" /db_xref="EnsemblGenomes-Tr:CAB14847" /db_xref="GOA:P55872" /db_xref="InterPro:IPR001288" /db_xref="InterPro:IPR019813" /db_xref="InterPro:IPR019814" /db_xref="InterPro:IPR019815" /db_xref="InterPro:IPR036787" /db_xref="InterPro:IPR036788" /db_xref="SubtiList:BG11944" /db_xref="UniProtKB/Swiss-Prot:P55872" /translation="MISKDQLVNEGIRAREVRLIGQNGDQLGIKSRQEALEIAGRANL DLVLVAANAKPPVCRIMDYGKFRFEQQKKEKEARKNQKIINLKEVRLSPTIDEHDFNT KLRNAIKFLEKGDKVKASIRFKGRAITHKEIGQRVLDRFSEACAEVATVETKPKMDGR SMFLMLAPKNEKQ*" /label="infC CDS" gene complement(2577152..2577673) /gene="infC" /locus_tag="BSU_28870" /old_locus_tag="BSU28870" /label="infC gene" misc_RNA complement(2577735..2577874) /locus_tag="BSU_misc_RNA_47" /product="mRNA L20_leader attenuator sequence" /experiment="publication(s) with functional evidences, PMID:17289755, 23611891" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17289755, 23611891" /label="mRNA L20 leader attenuator sequence" gene complement(2577735..2577874) /locus_tag="BSU_misc_RNA_47" /label="gene" promotor_-10 complement(2577871..2577890) /Source="Nicolas_upshift_promotors" /id="U2229" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.768231768231768" /psig=1 /xcortree=2647 /SigmaFactorBS="caatgtaaaagttgttccggataagtcgtcCTTGACTAaaga tccggtattGTGTAGAATAGTTATTGAATtgaatataaatcacaagcagaagcacccg c" /listShort="NA, infC, rpmI, rplT, ysdA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2577881) /Source="Nicolas_upshifts" /id="U2229" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.768231768231768" /psig=1 /xcortree=2647 /SigmaFactorBS="caatgtaaaagttgttccggataagtcgtcCTTGACTAaaga tccggtattGTGTAGAATAGTTATTGAATtgaatataaatcacaagcagaagcacccg c" /listShort="NA, infC, rpmI, rplT, ysdA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2577883..2577947) /Source="Nicolas_S_feature" /locus_tag="new_2953559_2953623_c" /HighExp="Paraq, G180, G150, G135, H2O2, LPh, C30, Oxctl, LBGexp, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1089" promotor_-35 complement(2577904..2577911) /Source="Nicolas_upshift_promotors" /id="U2229" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.768231768231768" /psig=1 /xcortree=2647 /SigmaFactorBS="caatgtaaaagttgttccggataagtcgtcCTTGACTAaaga tccggtattGTGTAGAATAGTTATTGAATtgaatataaatcacaagcagaagcacccg c" /listShort="NA, infC, rpmI, rplT, ysdA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2577929..2577948) /Source="Nicolas_upshift_promotors" /id="U2230" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.966033966033966" /psig=1 /xcortree=2590 /SigmaFactorBS="tttgtattctgggtggggatgaaagattttctttttctcTCT TGcgctcatagaaaaccCATGTTACAATGTAAAAGTTgttccggataagtcgtccttg a" /listShort="S1089, NA, infC, rpmI, rplT, ysdA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2577947) /Source="Nicolas_upshifts" /id="U2230" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.966033966033966" /psig=1 /xcortree=2590 /SigmaFactorBS="tttgtattctgggtggggatgaaagattttctttttctcTCT TGcgctcatagaaaaccCATGTTACAATGTAAAAGTTgttccggataagtcgtccttg a" /listShort="S1089, NA, infC, rpmI, rplT, ysdA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2577964..2577968) /Source="Nicolas_upshift_promotors" /id="U2230" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.966033966033966" /psig=1 /xcortree=2590 /SigmaFactorBS="tttgtattctgggtggggatgaaagattttctttttctcTCT TGcgctcatagaaaaccCATGTTACAATGTAAAAGTTgttccggataagtcgtccttg a" /listShort="S1089, NA, infC, rpmI, rplT, ysdA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2578066..2578073 /Source="Nicolas_upshift_promotors" /id="U2231" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2840 /SigmaFactorBS="attacgcaatttacaacaaaaccaccgacaggaagaaatGTA AAACAaagttaatctctgACCGATATAAGGAGCAGAAgggagcctgacacatgaacaa a" /listShort="yscB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2578087..2578105 /Source="Nicolas_upshift_promotors" /id="U2231" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2840 /SigmaFactorBS="attacgcaatttacaacaaaaccaccgacaggaagaaatGTA AAACAaagttaatctctgACCGATATAAGGAGCAGAAgggagcctgacacatgaacaa a" /listShort="yscB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2578087 /Source="Nicolas_upshifts" /id="U2231" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2840 /SigmaFactorBS="attacgcaatttacaacaaaaccaccgacaggaagaaatGTA AAACAaagttaatctctgACCGATATAAGGAGCAGAAgggagcctgacacatgaacaa a" /listShort="yscB" /GFF_Attribute="listLong" /label="upshifts" CDS 2578119..2578784 /gene="yscB" /locus_tag="BSU_28890" /old_locus_tag="BSU28890" /function="14: Cell envelope" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15033535; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_390767.2" /db_xref="EnsemblGenomes-Gn:BSU28890" /db_xref="EnsemblGenomes-Tr:CAB14849" /db_xref="SubtiList:BG12314" /db_xref="UniProtKB/Swiss-Prot:P94517" /translation="MNKLIQLALFFTLMLTGCSNSSTSSESKVETTVKTTAAFPQKEL EKELKKLKPVSLDMKFESPLATELGKRKAKEEAEKQRQIAAEKKLEKEREAKRKKQQE EKAERQRLAEQQAAERQRLAEAERQAELERQRQAAIQKEQKANAEKKRQSQAQRQQTE APSSNSQDPPSSSSQTDKTIQQPASELPDDDGYGYEERKKWHDDQVEWGIKQGYIDPE DAP*" /label="yscB CDS" gene 2578119..2578784 /gene="yscB" /locus_tag="BSU_28890" /old_locus_tag="BSU28890" /label="yscB gene" downshifts 2578762 /Source="Nicolas_upshifts" /id="D1479" /incds=0 /nref=27 /ntot=178 /MaxReadThrough="2.51181" /MaxDrop="3.43861" /score="13.4996084" /energy="-15.8" /TU="NA" /idTUdmin="U2231" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2578816..2579511) /gene="pftB" /locus_tag="BSU_28900" /old_locus_tag="BSU28900" /function="16.5: Explore" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15126464, 15849754, 16850406, 17452642, 26060272, 26406329, 28974613" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15126464, 15849754, 16850406, 17452642, 26060272, 26406329, 28974613; Product type t: transporter" /codon_start=1 /transl_table=11 /product="pyruvate import system subunit B" /protein_id="NP_390768.1" /db_xref="EnsemblGenomes-Gn:BSU28900" /db_xref="EnsemblGenomes-Tr:CAB14850" /db_xref="GOA:P94516" /db_xref="InterPro:IPR007300" /db_xref="InterPro:IPR024891" /db_xref="SubtiList:BG12312" /db_xref="UniProtKB/Swiss-Prot:P94516" /translation="MESTMSPYFGIVVSLAAFGIGTFLFKKTKGFFLFTPLFVAMVLG IAFLKIGGFSYADYNNGGEIIKFFLEPATIAFAIPLYKQRDKLKKYWWQIMASIIAGS ICSVTIVYLLAKGIHLDSAVMKSMLPQAATTAIALPLSKGIGGISDITAFAVIFNAVI VYALGALFLKVFKVKNPISKGLALGTSGHALGVAVGIEMGEVEAAMASIAVVVVGVVT VLVIPVFVQLIGG*" /label="pftB CDS" gene complement(2578816..2579511) /gene="pftB" /locus_tag="BSU_28900" /old_locus_tag="BSU28900" /label="pftB gene" downshifts complement(2578838) /Source="Nicolas_upshifts" /id="D1480" /incds=0 /nref=19 /ntot=45 /MaxReadThrough="1.25312" /MaxDrop="6.13174" /score="49.3872074" /energy="-13.7" /TU="NA" /idTUdmin="U2232" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2578882) /Source="Nicolas_upshifts" /id="D1481" /incds=1 /nref=2 /ntot=36 /MaxReadThrough="6.79502" /MaxDrop="3.1016" /score="49.3872074" /energy="-13.7" /TU="U2232" /idTUdmin="U2232" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" CDS complement(2579533..2579973) /gene="pftA" /locus_tag="BSU_28910" /old_locus_tag="BSU28910" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15659658, 17452642, 26060272, 27422364, 28974613" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15659658, 17452642, 26060272, 27422364, 28974613; Product type t : transporter" /codon_start=1 /transl_table=11 /product="pyruvate uptake system subunit A" /protein_id="NP_390769.1" /db_xref="EnsemblGenomes-Gn:BSU28910" /db_xref="EnsemblGenomes-Tr:CAB14851" /db_xref="GOA:P94515" /db_xref="InterPro:IPR005538" /db_xref="InterPro:IPR023736" /db_xref="SubtiList:BG12311" /db_xref="UniProtKB/Swiss-Prot:P94515" /translation="MSAKKVYGFLTQAFIFAVIMLVSNMIAAIVPIPIPASVVGLVLL FLLLCLKVIKLEQVETLGTSLTSLIGFLFVPSGISVMNSLGVMQQYGLQIVLVILLAT IILLGATGLFSQLILSLSGKRKTEADMKTKTVQSPQNNNELVHH*" /label="pftA CDS" gene complement(2579533..2579973) /gene="pftA" /locus_tag="BSU_28910" /old_locus_tag="BSU28910" /label="pftA gene" promotor_-10 complement(2579995..2580014) /Source="Nicolas_upshift_promotors" /id="U2232" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.434565434565435" /psig="0.982017982017982" /xcortree=1540 /SigmaFactorBS="ctgcaactcagacccgctatacggcatgttatcttgtaagcG CTTtataacagggaattcTTATTTATAATGAGGGTACCaaagagaaagaggtgaagaa a" /listShort="lrgA, lrgB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2580014) /Source="Nicolas_upshifts" /id="U2232" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.434565434565435" /psig="0.982017982017982" /xcortree=1540 /SigmaFactorBS="ctgcaactcagacccgctatacggcatgttatcttgtaagcG CTTtataacagggaattcTTATTTATAATGAGGGTACCaaagagaaagaggtgaagaa a" /listShort="lrgA, lrgB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2580030..2580033) /Source="Nicolas_upshift_promotors" /id="U2232" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.434565434565435" /psig="0.982017982017982" /xcortree=1540 /SigmaFactorBS="ctgcaactcagacccgctatacggcatgttatcttgtaagcG CTTtataacagggaattcTTATTTATAATGAGGGTACCaaagagaaagaggtgaagaa a" /listShort="lrgA, lrgB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2580107..2580832) /gene="lytT" /locus_tag="BSU_28920" /old_locus_tag="BSU28920" /function="16.13: Shape" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10940023, 11717295, 12034833, 12914674, 22937869, 25491472, 27127614, 27422364, 28348880" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10940023, 11717295, 12034833, 12914674, 22937869, 25491472, 27127614, 27422364, 28348880; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [LytS]" /protein_id="NP_390770.1" /db_xref="EnsemblGenomes-Gn:BSU28920" /db_xref="EnsemblGenomes-Tr:CAB14852" /db_xref="GOA:P94514" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR007492" /db_xref="InterPro:IPR011006" /db_xref="SubtiList:BG11953" /db_xref="UniProtKB/Swiss-Prot:P94514" /translation="MLRVLIVDDEMLARDELAYLLKRTNDEMEINEAENIESAFDQMM DQKPDLLFLDVDLSGENGFDIAKRLKKMKHPPAIVFATAYDQYALKAFEVDALDYLTK PFDEERIQQTLKKYKKVNRDIVETEQNSHAGQHKLALSVGESIVIVDTKDIIYAGTED GHVNVKTFDHSYTVSDTLVVIEKKLPDSDFIRVHRSFVVNTEYIKEIQPWFNSTYNLI MKDGSKIPVSRTYAKELKKLLHI*" /label="lytT CDS" gene complement(2580107..2580832) /gene="lytT" /locus_tag="BSU_28920" /old_locus_tag="BSU28920" /label="lytT gene" downshifts complement(2580136) /Source="Nicolas_upshifts" /id="D1482" /incds=0 /nref=231 /ntot=256 /MaxReadThrough="-0.0173499999999995" /MaxDrop="6.64673" /score="-8.47161605" /energy="-8.9" /TU="NA" /idTUdmin="U2232" /TUdmin="-1298" /isTUend="FALSE" /label="downshifts" CDS complement(2580810..2582591) /gene="lytS" /locus_tag="BSU_28930" /old_locus_tag="BSU28930" /function="16.3: Control" /function="16.13: Shape" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:10940023, 11717295, 12034833, 12914674, 22937869, 25491472, 27127614, 27422364, 28348880" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10940023, 11717295, 12034833, 12914674, 22937869, 25491472, 27127614, 27422364, 28348880; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [LytT]" /protein_id="NP_390771.1" /db_xref="EnsemblGenomes-Gn:BSU28930" /db_xref="EnsemblGenomes-Tr:CAB14853" /db_xref="GOA:P94513" /db_xref="InterPro:IPR003018" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR010559" /db_xref="InterPro:IPR011620" /db_xref="InterPro:IPR029016" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11952" /db_xref="UniProtKB/Swiss-Prot:P94513" /translation="MIHLMIMMLERVGIIVILGFILAHTKLFRQALQNQDGYKGKAIL ISIFSLFSIISNYTGIEIQRNMIVNNDWVFTIDPSGSIANTRILGVEIGGLLGGPFVG AGIGILAGLHRFSLGGSTALSCAVSSILAGVLAGLIGRYFTKRYRMPTPRIAALVGIG MESLQMIIILLMAKPFSDAWELVSMIGIPMILINGTGSFIFLSIIQAIIRKEEQARAL ETHRVLTIADQTLPFFRQGLNENSCKSVAAIIHKLTGTDAVSLTDKEKILAHVGAGMD HHIPSKSLITGLSKKVIKTGHIMKAISQEEIECTHAECPLHAAIVLPLTSNGNTIGTL KMYFKSPAGLSQVEEELAEGLAMLFSTQLELGEAELQSKLLKDAEIKALQAQVNPHFL FNAINTISALCRTDVEKTRKLLLQLSVYFRSNLQGARQLLIPLSKELNHLNAYLSLEQ ARFPGKYKIELNIDSRLEQIEIPPFVLQVLVENALRHAFPKKQDICKVTVCVLSDDAS VYMKVADNGRGIPPDVLPELGKKPFPSKEGTGTALYNLNQRLIGLFGQQAALHISSEV HKGTEVSFQVPMQQMKEGEEHAQGVNS*" /label="lytS CDS" gene complement(2580810..2582591) /gene="lytS" /locus_tag="BSU_28930" /old_locus_tag="BSU28930" /label="lytS gene" promotor_-35 2582675..2582678 /Source="Nicolas_upshift_promotors" /id="U2234" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.513486513486514" /psig="0.999000999001" /xcortree=3039 /SigmaFactorBS="cggctgactgtttttttaaaatcgtctgaaaacatATTTcac aaggcttttatCTATTGTAAAATAAAACATGagccttttggcagaaagatttgaatct g" /listShort="ysaA" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(2582687..2582706) /Source="Nicolas_upshift_promotors" /id="U2233" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.632367632367632" /psig="0.999000999001" /xcortree=3026 /SigmaFactorBS="tctcctctgcttcagattcaaatctttctgccaaaaggctca tgttTTATTTTACAATAGATAAAAgccttgtgaaatatgttttcagacgattttaaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2582692) /Source="Nicolas_upshifts" /id="U2233" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.632367632367632" /psig="0.999000999001" /xcortree=3026 /SigmaFactorBS="tctcctctgcttcagattcaaatctttctgccaaaaggctca tgttTTATTTTACAATAGATAAAAgccttgtgaaatatgttttcagacgattttaaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2582693..2582712 /Source="Nicolas_upshift_promotors" /id="U2234" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.513486513486514" /psig="0.999000999001" /xcortree=3039 /SigmaFactorBS="cggctgactgtttttttaaaatcgtctgaaaacatATTTcac aaggcttttatCTATTGTAAAATAAAACATGagccttttggcagaaagatttgaatct g" /listShort="ysaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2582700 /Source="Nicolas_upshifts" /id="U2234" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.513486513486514" /psig="0.999000999001" /xcortree=3039 /SigmaFactorBS="cggctgactgtttttttaaaatcgtctgaaaacatATTTcac aaggcttttatCTATTGTAAAATAAAACATGagccttttggcagaaagatttgaatct g" /listShort="ysaA" /GFF_Attribute="listLong" /label="upshifts" CDS 2582758..2583540 /gene="ysaA" /locus_tag="BSU_28940" /old_locus_tag="BSU28940" /EC_number="3.1.3.-" /experiment="publication(s) with functional evidences, PMID:15479782, 24123841, 25848029, 27784292" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15479782, 24123841, 25848029, 27784292; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous phosphatase" /protein_id="NP_390772.2" /db_xref="EnsemblGenomes-Gn:BSU28940" /db_xref="EnsemblGenomes-Tr:CAB14854" /db_xref="GOA:P94512" /db_xref="InterPro:IPR006439" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG12310" /db_xref="UniProtKB/Swiss-Prot:P94512" /translation="MKAVFFDLDDTLLWDEKSVRTTFAETCLQAEKKYGLAPEEFEAA VREAARELYMSYETYPYTVMIGINPFEGLWSNFSEPISEGFQKLNKIVPEYRRNAWTN GLKALGIDDPAYGEYLGEFFAAERRKRPFVYDETFAVLDQLKGKYELLLLTNGDPSLQ KEKLAGVPELAPYFNEIVISGAFGKGKPDVSIFEHCLKLMNIEKDDAIMVGDNLNTDI LGASRAGIKTVWINRTDKKNETDVKPDYIISSLHDLFPILEK*" /label="ysaA CDS" gene 2582758..2583540 /gene="ysaA" /locus_tag="BSU_28940" /old_locus_tag="BSU28940" /label="ysaA gene" downshifts 2583524 /Source="Nicolas_upshifts" /id="D1483" /incds=0 /nref=36 /ntot=265 /MaxReadThrough="1.0046" /MaxDrop="6.73727" /score="35.9560361" /energy="-13.8" /TU="NA" /idTUdmin="U2234" /TUdmin="-12" /isTUend="TRUE" /label="downshifts" downshifts complement(2583574) /Source="Nicolas_upshifts" /id="D1484" /incds=0 /nref=89 /ntot=246 /MaxReadThrough="1.13716" /MaxDrop="6.01766" /score="35.534455" /energy="-13.8" /TU="NA" /idTUdmin="U2235" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" CDS complement(2583581..2585512) /gene="thrS" /locus_tag="BSU_28950" /old_locus_tag="BSU28950" /EC_number="6.1.1.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8692931, 9826762, 10632708, 15831787, 22938038" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8692931, 9826762, 10632708, 15831787, 22938038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="threonyl-tRNA synthetase" /protein_id="NP_390773.1" /db_xref="EnsemblGenomes-Gn:BSU28950" /db_xref="EnsemblGenomes-Tr:CAB14855" /db_xref="GOA:P18255" /db_xref="InterPro:IPR002314" /db_xref="InterPro:IPR002320" /db_xref="InterPro:IPR004095" /db_xref="InterPro:IPR004154" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR012676" /db_xref="InterPro:IPR012947" /db_xref="InterPro:IPR018163" /db_xref="InterPro:IPR033728" /db_xref="InterPro:IPR036621" /db_xref="SubtiList:BG10362" /db_xref="UniProtKB/Swiss-Prot:P18255" /translation="MSDMVKITFPDGAVKEFAKGTTTEDIAASISPGLKKKSLAGKLN GKEIDLRTPINEDGTVEIITEGSEEGLQIMRHSAAHLLAQAIKRIYKDVKFGVGPVIE NGFYYDVEMDEAITPEDLPKIEKEMKKIVNANLPIVRKEVSREEAKARFAEIGDDLKL ELLDAIPEGETVSIYEQGEFFDLCRGVHVPSTGKIKEFKLLSLAGAYWRGDSKNQMLQ RVYGTAFFKKADLEEHLRMLEEAKERDHRKLGKELKLFANSQKVGQGLPLWLPKGATI RRVIERYIVDKEISLGYEHVYTPVLGSKELYETSGHWDHYQEGMFPPMEMDNETLVLR PMNCPHHMMIYKQDIHSYRELPIRIAELGTMHRYEMSGALSGLQRVRGMTLNDAHIFV RPDQIKDEFIRTVRLIQDVYEDFGLSDYTFRLSYRDPEDTEKYFDDDEMWNKAQSMLK EAMDEIGHDYYEAEGEAAFYGPKLDVQVKTAIGKEETLSTVQLDFLLPERFDLTYIGE DGKQHRPVVIHRGVVSTMERFVAFLIEEHKGALPTWLAPVQFQVIPVSPAVHLDYAKK VQERLQCEGLRVEVDSRDEKIGYKIREAQMQKIPYMLVVGDQEAENGAVNVRKYGEQN SETISLDEFVKKAVAEAKK*" /label="thrS CDS" gene complement(2583581..2585512) /gene="thrS" /locus_tag="BSU_28950" /old_locus_tag="BSU28950" /label="thrS gene" misc_RNA complement(2585556..2585803) /gene="tboT" /locus_tag="BSU_misc_RNA_48" /product="T-box riboswitch specific of threonine tRNA ligase" /experiment="publication(s) with functional evidences, PMID:9098041, 9826762, 1317842, 12165569, 12547201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9098041, 9826762, 1317842, 12165569, 12547201; Product type n: RNA" /function="16.3: Control" /label="tboT RNA" gene complement(2585556..2585803) /gene="tboT" /locus_tag="BSU_misc_RNA_48" /label="tboT gene" promotor_-10 complement(2585559..2585568) /Source="Nicolas_upshift_promotors" /id="U2235" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.308691308691309" /psig="0.0969030969030969" /xcortree=1774 /SigmaFactorBS="gtgtattggctttgcggaaaaaagggtggaacCacgattccg tttattcaaCCTCGTCCCTttcatagggggcggggtttttatatgcaaaaaaaggagt g" /listShort="thrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2585559) /Source="Nicolas_upshifts" /id="U2235" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.308691308691309" /psig="0.0969030969030969" /xcortree=1774 /SigmaFactorBS="gtgtattggctttgcggaaaaaagggtggaacCacgattccg tttattcaaCCTCGTCCCTttcatagggggcggggtttttatatgcaaaaaaaggagt g" /listShort="thrS" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(2585614) /Source="Nicolas_upshifts" /id="D1485" /incds=0 /nref=1 /ntot=16 /MaxReadThrough="6.71261" /MaxDrop="3.31801" /score="19.160794" /energy="-16.2" /TU="U2236,U2237,U2238,U2241" /idTUdmin="U2239" /TUdmin=221 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2585814..2585833) /Source="Nicolas_upshift_promotors" /id="U2236" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.460539460539461" /psig=1 /xcortree=2576 /SigmaFactorBS="aggctgtcggtttaaaaaaaaggaaacgcgatcgTGTTGatt ttttggattgaaCAATTTATAATACATAGGAGattaagaaagacacacgtattgataa g" /listShort="NA, thrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2585827) /Source="Nicolas_upshifts" /id="U2236" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.460539460539461" /psig=1 /xcortree=2576 /SigmaFactorBS="aggctgtcggtttaaaaaaaaggaaacgcgatcgTGTTGatt ttttggattgaaCAATTTATAATACATAGGAGattaagaaagacacacgtattgataa g" /listShort="NA, thrS" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2585829..2585909) /Source="Nicolas_S_feature" /locus_tag="new_2961505_2961585_c" /HighExp="S3, S4, LoTm, S5, G135, G180, LBGtran, T5.0H, G/S, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA, SigA, SigA" /TUshortPSig="1, 1, 0.998, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1090" promotor_-35 complement(2585849..2585853) /Source="Nicolas_upshift_promotors" /id="U2236" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.460539460539461" /psig=1 /xcortree=2576 /SigmaFactorBS="aggctgtcggtttaaaaaaaaggaaacgcgatcgTGTTGatt ttttggattgaaCAATTTATAATACATAGGAGattaagaaagacacacgtattgataa g" /listShort="NA, thrS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2585910..2586755) /gene="ytxC" /locus_tag="BSU_28960" /old_locus_tag="BSU28960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 22882546; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="sporulation protein" /protein_id="NP_390774.2" /db_xref="EnsemblGenomes-Gn:BSU28960" /db_xref="EnsemblGenomes-Tr:CAB14856" /db_xref="InterPro:IPR014199" /db_xref="SubtiList:BG10361" /db_xref="UniProtKB/Swiss-Prot:P06569" /translation="MLEIIFEDDHDAAAFLHLIQHSDDRNNIIVREGIRKIGIEKANP AFPIQRFMEPILVKFFLECKEDEHMLSLIEETYCFTDQDEQQQILQLAHSIIEGEADD LPFEPLKLSRKQSILDELQTICLEEGVFYIRSFQTFRLGSYYKQLRDITEAAIDEYKM EQEYQNFIQTLRDYVDAKQPRIKKVHIVHDGSFTLWELRYVPEREKMKYIDRRFVRDH PMYIDSHLLAPLISIAPDEVVLYTDQPEHMMARTIQNVFQERVEMLPLHAFTDAEIPV KHSEG*" /label="ytxC CDS" gene complement(2585910..2586755) /gene="ytxC" /locus_tag="BSU_28960" /old_locus_tag="BSU28960" /label="ytxC gene" promotor_-10 complement(2586775..2586793) /Source="Nicolas_upshift_promotors" /id="U2237" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1000 /SigmaFactorBS="caaattaagatttgccaatgacctttaCGTCTAttttaaaaa catcccCCATATACTTGTAACAGATgccgtaaggggggacaaacatgcttgaaataat c" /listShort="ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2586781) /Source="Nicolas_upshifts" /id="U2237" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1000 /SigmaFactorBS="caaattaagatttgccaatgacctttaCGTCTAttttaaaaa catcccCCATATACTTGTAACAGATgccgtaaggggggacaaacatgcttgaaataat c" /listShort="ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2586809..2586814) /Source="Nicolas_upshift_promotors" /id="U2237" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1000 /SigmaFactorBS="caaattaagatttgccaatgacctttaCGTCTAttttaaaaa catcccCCATATACTTGTAACAGATgccgtaaggggggacaaacatgcttgaaataat c" /listShort="ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2586834..2587475) /gene="ytxB" /locus_tag="BSU_28970" /old_locus_tag="BSU28970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 25728272, 27190159; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative osomosensing transporter" /protein_id="NP_390775.1" /db_xref="EnsemblGenomes-Gn:BSU28970" /db_xref="EnsemblGenomes-Tr:CAB14857" /db_xref="GOA:P06568" /db_xref="InterPro:IPR015414" /db_xref="InterPro:IPR032816" /db_xref="SubtiList:BG10360" /db_xref="UniProtKB/Swiss-Prot:P06568" /translation="MKRKTAVKWLAVLAGAGLLYWGNKTYLNVSPKEIRVWVLSFGVF APLMFIGISIVRPLVLFPVSVISIAGGLAFGPLLGTLYTLFGSMCASAVSFFAAGLFS AKKNGHYERLEAIQKQMEDNGFFYIFLLRILPINFDFVSYAAGLSNVKALPYFAATAV GIIPGTIALNVLGASFLAGNLPAFFMVLALYIVFISLPFIFRKKMQNLFQESN*" /label="ytxB CDS" gene complement(2586834..2587475) /gene="ytxB" /locus_tag="BSU_28970" /old_locus_tag="BSU28970" /label="ytxB gene" CDS complement(2587509..2588444) /gene="dnaI" /locus_tag="BSU_28980" /old_locus_tag="BSU28980" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12682299, 17003052, 17289076, 19255093, 19968790" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17003052, 17289076, 19255093, 19968790; Product type f: factor" /codon_start=1 /transl_table=11 /product="helicase loader" /protein_id="NP_390776.1" /db_xref="EnsemblGenomes-Gn:BSU28980" /db_xref="EnsemblGenomes-Tr:CAB14858" /db_xref="GOA:P06567" /db_xref="InterPro:IPR002611" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR009928" /db_xref="InterPro:IPR027417" /db_xref="PDB:2K7R" /db_xref="PDB:4M4W" /db_xref="SubtiList:BG10359" /db_xref="UniProtKB/Swiss-Prot:P06567" /translation="MEPIGRSLQGVTGRPDFQKRLEQMKEKVMKDQDVQAFLKENEEV IDQKMIEKSLNKLYEYIEQSKNCSYCSEDENCNNLLEGYHPKLVVNGRSIDIEYYECP VKRKLDQQKKQQSLMKSMYIQQDLLGATFQQVDISDPSRLAMFQHVTDFLKSYNETGK GKGLYLYGKFGVGKTFMLAAIANELAEKEYSSMIVYVPEFVRELKNSLQDQTLEEKLN MVKTTPVLMLDDIGAESMTSWVRDEVIGTVLQHRMSQQLPTFFSSNFSPDELKHHFTY SQRGEKEEVKAARLMERILYLAAPIRLDGENRRHP*" /label="dnaI CDS" gene complement(2587509..2588444) /gene="dnaI" /locus_tag="BSU_28980" /old_locus_tag="BSU28980" /label="dnaI gene" CDS complement(2588472..2589890) /gene="dnaB" /locus_tag="BSU_28990" /old_locus_tag="BSU28990" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12682299, 15186423, 16002087, 17289076, 20071750, 21097613, 23525462" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15186423, 16002087, 17289076, 20071750, 21097613, 23525462; Product type f: factor" /codon_start=1 /transl_table=11 /product="helicase loading protein; replication initiationmembrane attachment protein" /protein_id="NP_390777.1" /db_xref="EnsemblGenomes-Gn:BSU28990" /db_xref="EnsemblGenomes-Tr:CAB14859" /db_xref="GOA:P07908" /db_xref="InterPro:IPR006343" /db_xref="InterPro:IPR034829" /db_xref="SubtiList:BG10358" /db_xref="UniProtKB/Swiss-Prot:P07908" /translation="MADYWKDVLPVDPYVVKSRSMLQDIDRQIITQLYQPLIGPVAFS LYMTLWGELEQNRLWGGESTHRQLMGMTQSNLKTIHQEQGKLEGIGLLKVYMKESERQ ERLFIYELLPPLRPNEFFEDGMLNVFLYNRVGKTKYQQLKQFFTHPAISEDAKDITRP FNHAFESLQPSEWKLTSDMEETVRLAEGSEYTSVGQSPSYTITEDVFDFDLFLAGLSE TMIPRKAMTQQVRDTIKKLSYLYGIDPLQMQNVVMSAIDERDVITTEALRKAASDWYQ IERNGQLPDLVEKTQPVHLREGEQPAEEDSLDGKLIALLEAISPKKLLQDIADGTEPS KADLKIIEEIMFEQKLEPGVTNVLIYYVMLKTDMKLSKNYIQKIASHWARKKVKTVRE AMKLAIEENRQYLEWAEGKTKSSKRNQKVIREEKLPDWMTEKETASDSESGQQKLHPQ DLEEQKKKMMEEMQKLKKYSAY*" /label="dnaB CDS" gene complement(2588472..2589890) /gene="dnaB" /locus_tag="BSU_28990" /old_locus_tag="BSU28990" /label="dnaB gene" promotor_-10 complement(2589919..2589938) /Source="Nicolas_upshift_promotors" /id="U2238" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2245 /SigmaFactorBS="ttctagctcttttctcatgtgcaaaattggcATTTgatagat ataagaaACGGTGTAAAATGAAAGGTAgaaacaaattcggaaggtttgagaatgtatg g" /listShort="dnaB, dnaI, ytxB, ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2589927) /Source="Nicolas_upshifts" /id="U2238" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2245 /SigmaFactorBS="ttctagctcttttctcatgtgcaaaattggcATTTgatagat ataagaaACGGTGTAAAATGAAAGGTAgaaacaaattcggaaggtttgagaatgtatg g" /listShort="dnaB, dnaI, ytxB, ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2589953..2589956) /Source="Nicolas_upshift_promotors" /id="U2238" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2245 /SigmaFactorBS="ttctagctcttttctcatgtgcaaaattggcATTTgatagat ataagaaACGGTGTAAAATGAAAGGTAgaaacaaattcggaaggtttgagaatgtatg g" /listShort="dnaB, dnaI, ytxB, ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2590005..2590463) /gene="nrdR" /locus_tag="BSU_29000" /old_locus_tag="BSU29000" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16950922, 27920297, 28624879" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16950922, 27920297, 28624879; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of transcription of ribonucleotide reductase nrd genes and operons" /protein_id="NP_390778.1" /db_xref="EnsemblGenomes-Gn:BSU29000" /db_xref="EnsemblGenomes-Tr:CAB14860" /db_xref="GOA:Q45549" /db_xref="InterPro:IPR003796" /db_xref="InterPro:IPR005144" /db_xref="SubtiList:BG13833" /db_xref="UniProtKB/Swiss-Prot:Q45549" /translation="MKCPSCQHNGTRVLDSRPVDDGKSIRRRRECESCHYRFTTFEKV EETPLIVVKKEGVREEFSREKMLRGLIKACEKRPVSLKTLEDMCFDIEKELRNQGCSE VKSELVGEMVMDRLAKIDEVAYVRFASVYRQFKDINVFIDELKDLIKKER*" /label="nrdR CDS" gene complement(2590005..2590463) /gene="nrdR" /locus_tag="BSU_29000" /old_locus_tag="BSU29000" /label="nrdR gene" downshifts complement(2590024) /Source="Nicolas_upshifts" /id="D1486" /incds=0 /nref=14 /ntot=175 /MaxReadThrough="4.1553" /MaxDrop="3.90408" /score="12.4797073" /energy="-21.2" /TU="U2239,U2241" /idTUdmin="U2243" /TUdmin="-9" /isTUend="TRUE" /label="downshifts" S_feature complement(2590464..2590611) /Source="Nicolas_S_feature" /locus_tag="new_2966140_2966287_c" /HighExp="dia5, dia15, Lbstat, Diami, Heat, M9-stat, M0t90, M40t90, LBGtran, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigGF, SigA" /TUshortPSig="0.998, 0.996, 0.654, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1091" promotor_-10 complement(2590602..2590621) /Source="Nicolas_upshift_promotors" /id="U2239" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.917082917082917" /psig="0.998001998001998" /xcortree=1862 /SigmaFactorBS="cttttatttttataaagaaacgagagtgtcagCTTTttcttt tttcatttTTTTTGTAAAATAAGAAGGAgattttcacaaaccacctaatgctatagaa a" /listShort="S1091, nrdR, dnaB, dnaI, ytxB, ytxC, S1090" /listLong="NA, thrS" /label="promotor_-10" upshifts complement(2590611) /Source="Nicolas_upshifts" /id="U2239" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.917082917082917" /psig="0.998001998001998" /xcortree=1862 /SigmaFactorBS="cttttatttttataaagaaacgagagtgtcagCTTTttcttt tttcatttTTTTTGTAAAATAAGAAGGAgattttcacaaaccacctaatgctatagaa a" /listShort="S1091, nrdR, dnaB, dnaI, ytxB, ytxC, S1090" /listLong="NA, thrS" /label="upshifts" S_feature complement(2590613..2590691) /Source="Nicolas_S_feature" /locus_tag="new_2966289_2966367_c" /HighExp="Lbstat, M40t90, Heat, M9-stat, M0t90, G180, S8, S5, T1.30H, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF, SigA" /TUshortPSig="0.996, 0.654, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1092" promotor_-35 complement(2590636..2590639) /Source="Nicolas_upshift_promotors" /id="U2239" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.917082917082917" /psig="0.998001998001998" /xcortree=1862 /SigmaFactorBS="cttttatttttataaagaaacgagagtgtcagCTTTttcttt tttcatttTTTTTGTAAAATAAGAAGGAgattttcacaaaccacctaatgctatagaa a" /listShort="S1091, nrdR, dnaB, dnaI, ytxB, ytxC, S1090" /listLong="NA, thrS" /label="promotor_-35" downshifts complement(2590736) /Source="Nicolas_upshifts" /id="D1487" /incds=0 /nref=204 /ntot=262 /MaxReadThrough="5.70146" /MaxDrop="5.85416" /score="12.4797073" /energy="-21.2" /TU="U2241,U2242,U2243" /idTUdmin="U2242" /TUdmin="-237" /isTUend="FALSE" /label="downshifts" CDS complement(2590737..2591117) /gene="speD" /locus_tag="BSU_29010" /old_locus_tag="BSU29010" /EC_number="4.1.1.50" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9723923, 10844697, 28546427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9723923, 10844697, 28546427; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="S-adenosylmethionine decarboxylase" /protein_id="NP_390779.2" /db_xref="EnsemblGenomes-Gn:BSU29010" /db_xref="EnsemblGenomes-Tr:CAB14861" /db_xref="GOA:O34426" /db_xref="InterPro:IPR003826" /db_xref="InterPro:IPR016067" /db_xref="InterPro:IPR017716" /db_xref="SubtiList:BG13832" /db_xref="UniProtKB/Swiss-Prot:O34426" /translation="METMGRHVISELWGCDFDKLNDMDFIEKTFVNAALKSGAEVREV AFHKFAPQGVSGVVIISESHLTIHSFPEHGYASIDVYTCGDLDPNVAADYIAEALHAD TRENIEIPRGMGPVQIKQAQAKVL*" /label="speD CDS" gene complement(2590737..2591117) /gene="speD" /locus_tag="BSU_29010" /old_locus_tag="BSU29010" /label="speD gene" S_feature complement(2591118..2591272) /Source="Nicolas_S_feature" /locus_tag="new_2966794_2966948_c" /HighExp="Lbstat, M40t90, M9-stat, T2.0H, T3.0H, M0t90, T3.30H, Sw, T1.30H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF, SigA" /TUshortPSig="0.996, 0.654, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1093" promotor_-10 complement(2591252..2591271) /Source="Nicolas_upshift_promotors" /id="U2241" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.613386613386613" /psig="0.996003996003996" /xcortree=337 /SigmaFactorBS="aagaaaaaacccttaacagcatatttctgaaaaaacgcacCT TGCAAattagacttaaacaCAGTATACTATTTTTCGTGAacttcttgcttgagactgt t" /listShort="S1093, speD, S1092, S1091, nrdR, dnaB, dnaI, ytxB, ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2591259 /Source="Nicolas_upshifts" /id="U2240" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.300699300699301" /psig="0.822177822177822" /xcortree=292 /SigmaFactorBS="ccggagaggtcctaaccctttaagtaattccgaaacagtctc aagcaagaagttcacgaaaAATAGTATACTGTGTTTAAGtctaatttgcaaggtgcgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 2591260..2591279 /Source="Nicolas_upshift_promotors" /id="U2240" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.300699300699301" /psig="0.822177822177822" /xcortree=292 /SigmaFactorBS="ccggagaggtcctaaccctttaagtaattccgaaacagtctc aagcaagaagttcacgaaaAATAGTATACTGTGTTTAAGtctaatttgcaaggtgcgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2591272) /Source="Nicolas_upshifts" /id="U2241" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.613386613386613" /psig="0.996003996003996" /xcortree=337 /SigmaFactorBS="aagaaaaaacccttaacagcatatttctgaaaaaacgcacCT TGCAAattagacttaaacaCAGTATACTATTTTTCGTGAacttcttgcttgagactgt t" /listShort="S1093, speD, S1092, S1091, nrdR, dnaB, dnaI, ytxB, ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2591286..2591292) /Source="Nicolas_upshift_promotors" /id="U2241" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.613386613386613" /psig="0.996003996003996" /xcortree=337 /SigmaFactorBS="aagaaaaaacccttaacagcatatttctgaaaaaacgcacCT TGCAAattagacttaaacaCAGTATACTATTTTTCGTGAacttcttgcttgagactgt t" /listShort="S1093, speD, S1092, S1091, nrdR, dnaB, dnaI, ytxB, ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2591350..2591361) /Source="Nicolas_upshift_promotors" /id="U2242" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.654345654345654" /psig="0.654345654345654" /xcortree=339 /SigmaFactorBS="gcagagttgttgatctaatccgccatgtagcggcaCGAATGA aacatccgtctgctGTATAAAATAAGgtcatggacacattttaaagaaaaaaccctta a" /listShort="S1093, speD, S1092, S1091" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2591356..2592378) /gene="gapB" /locus_tag="BSU_29020" /old_locus_tag="BSU29020" /EC_number="1.2.1.59" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10799476, 10844697, 15720552, 22720735, 26735940, 27449348, 28760849" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10799476, 10844697, 15720552, 22720735, 26735940, 27449348, 28760849; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glyceraldehyde-3-phosphate dehydrogenase (NADP-dependent, gluconeogenesis)" /protein_id="NP_390780.1" /db_xref="EnsemblGenomes-Gn:BSU29020" /db_xref="EnsemblGenomes-Tr:CAB14862" /db_xref="GOA:O34425" /db_xref="InterPro:IPR006424" /db_xref="InterPro:IPR020828" /db_xref="InterPro:IPR020829" /db_xref="InterPro:IPR020830" /db_xref="InterPro:IPR020831" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12592" /db_xref="UniProtKB/Swiss-Prot:O34425" /translation="MKVKVAINGFGRIGRMVFRKAMLDDQIQVVAINASYSAETLAHL IKYDTIHGRYDKEVVAGEDSLIVNGKKVLLLNSRDPKQLPWREYDIDIVVEATGKFNA KDKAMGHIEAGAKKVILTAPGKNEDVTIVMGVNEDQFDAERHVIISNASCTTNCLAPV VKVLDEEFGIESGLMTTVHAYTNDQKNIDNPHKDLRRARACGESIIPTTTGAAKALSL VLPHLKGKLHGLALRVPVPNVSLVDLVVDLKTDVTAEEVNEAFKRAAKTSMYGVLDYS DEPLVSTDYNTNPHSAVIDGLTTMVMEDRKVKVLAWYDNEWGYSCRVVDLIRHVAARM KHPSAV*" /label="gapB CDS" gene complement(2591356..2592378) /gene="gapB" /locus_tag="BSU_29020" /old_locus_tag="BSU29020" /label="gapB gene" upshifts complement(2591357) /Source="Nicolas_upshifts" /id="U2242" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.654345654345654" /psig="0.654345654345654" /xcortree=339 /SigmaFactorBS="gcagagttgttgatctaatccgccatgtagcggcaCGAATGA aacatccgtctgctGTATAAAATAAGgtcatggacacattttaaagaaaaaaccctta a" /listShort="S1093, speD, S1092, S1091" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2591376..2591382) /Source="Nicolas_upshift_promotors" /id="U2242" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.654345654345654" /psig="0.654345654345654" /xcortree=339 /SigmaFactorBS="gcagagttgttgatctaatccgccatgtagcggcaCGAATGA aacatccgtctgctGTATAAAATAAGgtcatggacacattttaaagaaaaaaccctta a" /listShort="S1093, speD, S1092, S1091" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2592422..2592441) /Source="Nicolas_upshift_promotors" /id="U2243" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=347 /SigmaFactorBS="acataagatgcatcataaattagcgttataatcgttgatttt tatcaatatgTACTGGCGaatttgttttaaTGTGTTATACTAATTTTAGAtagtaaca a" /listShort="gapB, S1093, speD, S1092, S1091, nrdR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2592453) /Source="Nicolas_upshifts" /id="U2243" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=347 /SigmaFactorBS="acataagatgcatcataaattagcgttataatcgttgatttt tatcaatatgTACTGGCGaatttgttttaaTGTGTTATACTAATTTTAGAtagtaaca a" /listShort="gapB, S1093, speD, S1092, S1091, nrdR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2592454..2592461) /Source="Nicolas_upshift_promotors" /id="U2243" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=347 /SigmaFactorBS="acataagatgcatcataaattagcgttataatcgttgatttt tatcaatatgTACTGGCGaatttgttttaaTGTGTTATACTAATTTTAGAtagtaaca a" /listShort="gapB, S1093, speD, S1092, S1091, nrdR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2592584..2592964) /gene="ytcD" /locus_tag="BSU_29030" /old_locus_tag="BSU29030" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23504016; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (HxlR family)" /protein_id="NP_390781.1" /db_xref="EnsemblGenomes-Gn:BSU29030" /db_xref="EnsemblGenomes-Tr:CAB14863" /db_xref="GOA:O34533" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2HZT" /db_xref="SubtiList:BG13831" /db_xref="UniProtKB/Swiss-Prot:O34533" /translation="MEKKKYNISVEATLEVIGGKWKCVILCHLTHGKKRTSELKRLMP NITQKMLTQQLRELEADGVINRIVYNQVPPKVEYELSEYGRSLEGILDMLCAWGANHI NRVYGDTFSVLEESVLNDKLKQES*" /label="ytcD CDS" gene complement(2592584..2592964) /gene="ytcD" /locus_tag="BSU_29030" /old_locus_tag="BSU29030" /label="ytcD gene" downshifts complement(2592608) /Source="Nicolas_upshifts" /id="D1488" /incds=0 /nref=17 /ntot=164 /MaxReadThrough="1.55675" /MaxDrop="3.64816" /score="18.9828659" /energy="-15.3" /TU="NA" /idTUdmin="U2245" /TUdmin=3 /isTUend="TRUE" /label="downshifts" S_feature complement(2592965..2593095) /Source="Nicolas_S_feature" /locus_tag="new_2968641_2968771_c" /HighExp="dia15, Diami, dia5, LBGstat, G180, Etha, S5, LBGtran, H2O2, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.972" /TUlongSig="NA" /TUlongPSig="NA" /label="S1094" promotor_-35 2593020..2593024 /Source="Nicolas_upshift_promotors" /id="U2244" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.87012987012987" /psig="0.972027972027972" /xcortree=2468 /SigmaFactorBS="acaggcaccaaaaagtgactatagcacttcaaagtacgtACT TTtatttcttaacgataTGTTTCATAATCACATTTGCcggctgatttgaatctgctct t" /listShort="S1095, ytbD, ytbE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2593040..2593059 /Source="Nicolas_upshift_promotors" /id="U2244" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.87012987012987" /psig="0.972027972027972" /xcortree=2468 /SigmaFactorBS="acaggcaccaaaaagtgactatagcacttcaaagtacgtACT TTtatttcttaacgataTGTTTCATAATCACATTTGCcggctgatttgaatctgctct t" /listShort="S1095, ytbD, ytbE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2593041..2593147 /Source="Nicolas_S_feature" /locus_tag="new_2968717_2968823" /HighExp="Diami, G180, G135, LBGstat, G150, LBGexp, Paraq, Oxctl, dia5, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.972" /TUlongSig="NA" /TUlongPSig="NA" /label="S1095" upshifts 2593041 /Source="Nicolas_upshifts" /id="U2244" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.87012987012987" /psig="0.972027972027972" /xcortree=2468 /SigmaFactorBS="acaggcaccaaaaagtgactatagcacttcaaagtacgtACT TTtatttcttaacgataTGTTTCATAATCACATTTGCcggctgatttgaatctgctct t" /listShort="S1095, ytbD, ytbE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2593085..2593104) /Source="Nicolas_upshift_promotors" /id="U2245" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.935064935064935" /psig="0.972027972027972" /xcortree=1937 /SigmaFactorBS="gaagtcatgatgttcctcctttgtaagatGTGTTGTAtgatt gaaattctgCCGAGTAAGCTATATAAATAaaaaagagcagattcaaatcagccggcaa a" /listShort="S1094, ytcD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2593095) /Source="Nicolas_upshifts" /id="U2245" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.935064935064935" /psig="0.972027972027972" /xcortree=1937 /SigmaFactorBS="gaagtcatgatgttcctcctttgtaagatGTGTTGTAtgatt gaaattctgCCGAGTAAGCTATATAAATAaaaaagagcagattcaaatcagccggcaa a" /listShort="S1094, ytcD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2593119..2593126) /Source="Nicolas_upshift_promotors" /id="U2245" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.935064935064935" /psig="0.972027972027972" /xcortree=1937 /SigmaFactorBS="gaagtcatgatgttcctcctttgtaagatGTGTTGTAtgatt gaaattctgCCGAGTAAGCTATATAAATAaaaaagagcagattcaaatcagccggcaa a" /listShort="S1094, ytcD" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2593148..2594338 /gene="ytbD" /locus_tag="BSU_29040" /old_locus_tag="BSU29040" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 23504016; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_390782.1" /db_xref="EnsemblGenomes-Gn:BSU29040" /db_xref="EnsemblGenomes-Tr:CAB14864" /db_xref="GOA:O34367" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13825" /db_xref="UniProtKB/Swiss-Prot:O34367" /translation="MTSANKSNIPALLALAVSAFAIGTTEFISVGLLPLIADDLDIPV TTAGLTVSLYALGVTFGAPILTSLTSSMSRKTLLLWIMFIFIAGNTMAATASSIGILL AARVISAFSHGVFMSIGSTIAADIVPEDKRASAISIMFTGLTVATVTGVPFGTFIGQQ FGWRFAFMVIIAVGIIAFITNGILVPSKLRKGTKTTMRDQLKLVTNSRLLLLFVITAL GYGGTFVVFTYLSPLLQEVTGFKAGTVAVILLGYGIAIAIGNMIGGKLSNRNPIAALF YMFIVQAIVLFVLTFTAPYQAAGLITILCMGLLAFMNVPGLQVYVVMLAERFVPSAVD VASAMNIAAFNAGIALGSYLGGVITDSIGLIHTAWIGGLMVVGAVILTGWSRLMEKRD RQEA*" /label="ytbD CDS" gene 2593148..2594338 /gene="ytbD" /locus_tag="BSU_29040" /old_locus_tag="BSU29040" /label="ytbD gene" promotor_-10 complement(2593970..2593988) /Source="Nicolas_upshift_promotors" /id="U2246" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1038 /SigmaFactorBS="agccctgctgcttgatacggggctgtaaatgtcagtaCGAAT AgaacgattgcctgtaCGATAAACATATAGAATAAagcggcaatcggatttcggtttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2593986) /Source="Nicolas_upshifts" /id="U2246" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1038 /SigmaFactorBS="agccctgctgcttgatacggggctgtaaatgtcagtaCGAAT AgaacgattgcctgtaCGATAAACATATAGAATAAagcggcaatcggatttcggtttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2594004..2594009) /Source="Nicolas_upshift_promotors" /id="U2246" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1038 /SigmaFactorBS="agccctgctgcttgatacggggctgtaaatgtcagtaCGAAT AgaacgattgcctgtaCGATAAACATATAGAATAAagcggcaatcggatttcggtttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2594362..2595204 /gene="ytbE" /locus_tag="BSU_29050" /old_locus_tag="BSU29050" /EC_number="1.1.1.-" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:19585557, 20981419, 28032445, 28130301" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19585557, 20981419, 28032445, 28130301; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous aldo/keto reductase" /protein_id="NP_390783.1" /db_xref="EnsemblGenomes-Gn:BSU29050" /db_xref="EnsemblGenomes-Tr:CAB14865" /db_xref="GOA:O34678" /db_xref="InterPro:IPR018170" /db_xref="InterPro:IPR020471" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="PDB:3B3D" /db_xref="SubtiList:BG13826" /db_xref="UniProtKB/Swiss-Prot:O34678" /translation="MTTHLQAKATLHNGVEMPWFGLGVFQVEEGSELVNAVKTAIVHG YRSIDTAAIYGNEAGVGEGIREGIEEAGISREDLFITSKVWNADLGYEETLAAFETSL SKLGLDYLDLYLIHWPVEGKYKEAWRALETLYKEGRIKAIGVSNFQIHHLEDLMTAAE IKPMINQVEFHPRLTQKELIRYCQNQGIQMEAWSPLMQGQLLDHPVLADIAQTYNKSV AQIILRWDLQHGIITIPKSTKEHRIKENASVFDFELTQDDMNRIDALNENLRVGPDPD NFDF*" /label="ytbE CDS" gene 2594362..2595204 /gene="ytbE" /locus_tag="BSU_29050" /old_locus_tag="BSU29050" /label="ytbE gene" promotor_-35 2594977..2594982 /Source="Nicolas_upshift_promotors" /id="U2247" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1181 /SigmaFactorBS="ggtcacctttaatgcagggacagctgctggatcaccctGTAT TGgctgacatcgctcaaACATATAATAAATCTGTCGcacaaattattttgcgctggga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2594998..2595016 /Source="Nicolas_upshift_promotors" /id="U2247" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1181 /SigmaFactorBS="ggtcacctttaatgcagggacagctgctggatcaccctGTAT TGgctgacatcgctcaaACATATAATAAATCTGTCGcacaaattattttgcgctggga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2594999 /Source="Nicolas_upshifts" /id="U2247" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1181 /SigmaFactorBS="ggtcacctttaatgcagggacagctgctggatcaccctGTAT TGgctgacatcgctcaaACATATAATAAATCTGTCGcacaaattattttgcgctggga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2595197 /Source="Nicolas_upshifts" /id="D1489" /incds=0 /nref=13 /ntot=124 /MaxReadThrough="1.16017" /MaxDrop="5.72508" /score="24.0721062" /energy="-11.4" /TU="NA" /idTUdmin="U2244" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2595237) /Source="Nicolas_upshifts" /id="D1490" /incds=0 /nref=168 /ntot=263 /MaxReadThrough="3.38494" /MaxDrop="6.57333" /score="13.4291259" /energy="-11.4" /TU="NA" /idTUdmin="U2248" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" CDS complement(2595246..2595839) /gene="coaE" /locus_tag="BSU_29060" /old_locus_tag="BSU29060" /EC_number="2.7.1.24" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10939241, 11886213, 12538896, 12682299, 15044829, 15526298, 17603993; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dephosphocoenzyme A kinase" /protein_id="NP_390784.1" /db_xref="EnsemblGenomes-Gn:BSU29060" /db_xref="EnsemblGenomes-Tr:CAB14866" /db_xref="GOA:O34932" /db_xref="InterPro:IPR001977" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13824" /db_xref="UniProtKB/Swiss-Prot:O34932" /translation="MTLVIGLTGGIASGKSTVANMLIEKGITVIDADIIAKQAVEKGM PAYRQIIDEFGEDILLSNGDIDRKKLGALVFTNEQKRLALNAIVHPAVRQEMLNRRDE AVANREAFVVLDIPLLFESKLESLVDKIIVVSVTKELQLERLMKRNQLTEEEAVSRIR SQMPLEEKTARADQVIDNSGTLEETKRQLDEIMNSWA*" /label="coaE CDS" gene complement(2595246..2595839) /gene="coaE" /locus_tag="BSU_29060" /old_locus_tag="BSU29060" /label="coaE gene" CDS complement(2595855..2596487) /gene="spcF" /locus_tag="BSU_29070" /old_locus_tag="BSU29070" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 23396918" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 23396918; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="membrane calmodulin-like protein essential for stage III sporulation" /protein_id="NP_390785.2" /db_xref="EnsemblGenomes-Gn:BSU29070" /db_xref="EnsemblGenomes-Tr:CAB14867" /db_xref="GOA:C0SP79" /db_xref="InterPro:IPR003810" /db_xref="InterPro:IPR014205" /db_xref="SubtiList:BG13823" /db_xref="UniProtKB/Swiss-Prot:C0SP79" /translation="MQMVSILLLALAVSLDSFSVGFTYGLRKMKIPFKAILVIACCSG AVMFISMLIGSFLTKFFPVYVTEKLGGLILVGIGAWVLYQFFKPAKDKEYLLHEKTLL NLEVRSLGIVIHILRKPMSADIDKSGVINGIEAVLLGFALSIDAFGAGIGAAILGFSP IVMSIAVAIMSSLFVSIGINAGHFLSKWKWIDKMAFLPGLLLITIGLWKL*" /label="spcF CDS" gene complement(2595855..2596487) /gene="spcF" /locus_tag="BSU_29070" /old_locus_tag="BSU29070" /label="spcF gene" S_feature complement(2596488..2596652) /Source="Nicolas_S_feature" /locus_tag="new_2972164_2972328_c" /HighExp="LPhT, dia15, Sw, LBGtran, LBGstat, H2O2, Diami, G135, Lbstat, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S1096" CDS complement(2596653..2597483) /gene="mutM" /locus_tag="BSU_29080" /old_locus_tag="BSU29080" /EC_number="3.2.2.23" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15109717, 25825434, 28517932; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="formamidopyrimidine-DNA glycosylase; 5-hydroxymethyl-uracil DNA-glycosylase" /protein_id="NP_390786.2" /db_xref="EnsemblGenomes-Gn:BSU29080" /db_xref="EnsemblGenomes-Tr:CAB14868" /db_xref="GOA:O34403" /db_xref="InterPro:IPR000214" /db_xref="InterPro:IPR010663" /db_xref="InterPro:IPR010979" /db_xref="InterPro:IPR012319" /db_xref="InterPro:IPR015886" /db_xref="InterPro:IPR015887" /db_xref="InterPro:IPR020629" /db_xref="InterPro:IPR035937" /db_xref="SubtiList:BG12628" /db_xref="UniProtKB/Swiss-Prot:O34403" /translation="MPELPEVETVRRTLTGLVKGKTIKSVEIRWPNIIKRPAEPEEFA RKLAGETIQSIGRRGKFLLFHLDHYVMVSHLRMEGKYGLHQAEEPDDKHVHVIFTMTD GTQLRYRDVRKFGTMHLFKPGEEAGELPLSQLGPEPDAEEFTSAYLKDRLAKTNRAVK TALLDQKTVVGLGNIYVDEALFRAGVHPETKANQLSDKTIKTLHAEIKNTLQEAIDAG GSTVRSYINSQGEIGMFQLQHFVYGKKDEPCKNCGTMISKIVVGGRGTHFCAKCQTKK *" /label="mutM CDS" gene complement(2596653..2597483) /gene="mutM" /locus_tag="BSU_29080" /old_locus_tag="BSU29080" /label="mutM gene" CDS complement(2597506..2600148) /gene="polA" /locus_tag="BSU_29090" /old_locus_tag="BSU29090" /EC_number="2.7.7.7" /function="16.9: Replicate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:3125407, 6777244, 9231429, 12081953, 17905985, 27399782" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3125407, 6777244, 9231429, 12081953, 17905985, 27399782; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase I" /protein_id="NP_390787.1" /db_xref="EnsemblGenomes-Gn:BSU29090" /db_xref="EnsemblGenomes-Tr:CAB14869" /db_xref="GOA:O34996" /db_xref="InterPro:IPR001098" /db_xref="InterPro:IPR002298" /db_xref="InterPro:IPR002421" /db_xref="InterPro:IPR002562" /db_xref="InterPro:IPR008918" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR018320" /db_xref="InterPro:IPR019760" /db_xref="InterPro:IPR020045" /db_xref="InterPro:IPR020046" /db_xref="InterPro:IPR029060" /db_xref="InterPro:IPR036279" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG12656" /db_xref="UniProtKB/Swiss-Prot:O34996" /translation="MTERKKLVLVDGNSLAYRAFFALPLLSNDKGVHTNAVYGFAMIL MKMLEDEKPTHMLVAFDAGKTTFRHGTFKEYKGGRQKTPPELSEQMPFIRELLDAYQI SRYELEQYEADDIIGTLAKSAEKDGFEVKVFSGDKDLTQLATDKTTVAITRKGITDVE FYTPEHVKEKYGLTPEQIIDMKGLMGDSSDNIPGVPGVGEKTAIKLLKQFDSVEKLLE SIDEVSGKKLKEKLEEFKDQALMSKELATIMTDAPIEVSVSGLEYQGFNREQVIAIFK DLGFNTLLERLGEDSAEAEQDQSLEDINVKTVTDVTSDILVSPSAFVVEQIGDNYHEE PILGFSIVNETGAYFIPKDIAVESEVFKEWVENDEQKKWVFDSKRAVVALRWQGIELK GAEFDTLLAAYIINPGNSYDDVASVAKDYGLHIVSSDESVYGKGAKRAVPSEDVLSEH LGRKALAIQSLREKLVQELENNDQLELFEELEMPLALILGEMESTGVKVDVDRLKRMG EELGAKLKEYEEKIHEIAGEPFNINSPKQLGVILFEKIGLPVVKKTKTGYSTSADVLE KLADKHDIVDYILQYRQIGKLQSTYIEGLLKVTRPDSHKVHTRFNQALTQTGRLSSTD PNLQNIPIRLEEGRKIRQAFVPSEKDWLIFAADYSQIELRVLAHISKDENLIEAFTND MDIHTKTAMDVFHVAKDEVTSAMRRQAKAVNFGIVYGISDYGLSQNLGITRKEAGAFI DRYLESFQGVKAYMEDSVQEAKQKGYVTTLMHRRRYIPELTSRNFNIRSFAERTAMNT PIQGSAADIIKKAMIDMAAKLKEKQLKARLLLQVHDELIFEAPKEEIEILEKLVPEVM EHALALDVPLKVDFASGPSWYDAK*" /label="polA CDS" gene complement(2597506..2600148) /gene="polA" /locus_tag="BSU_29090" /old_locus_tag="BSU29090" /label="polA gene" promotor_-10 complement(2600203..2600222) /Source="Nicolas_upshift_promotors" /id="U2248" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=1979 /SigmaFactorBS="cttttttgtgtcttctcttatagttcacgTATTTTCCtttca aattgaacTTTGTTAAAATAAGAGGAGCtaatgactatgtaagagatgaatggaagcc t" /listShort="polA, mutM, S1096, ytaF, coaE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2600212) /Source="Nicolas_upshifts" /id="U2248" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=1979 /SigmaFactorBS="cttttttgtgtcttctcttatagttcacgTATTTTCCtttca aattgaacTTTGTTAAAATAAGAGGAGCtaatgactatgtaagagatgaatggaagcc t" /listShort="polA, mutM, S1096, ytaF, coaE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2600236..2600243) /Source="Nicolas_upshift_promotors" /id="U2248" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=1979 /SigmaFactorBS="cttttttgtgtcttctcttatagttcacgTATTTTCCtttca aattgaacTTTGTTAAAATAAGAGGAGCtaatgactatgtaagagatgaatggaagcc t" /listShort="polA, mutM, S1096, ytaF, coaE" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2600272..2600391) /Source="Nicolas_S_feature" /locus_tag="new_2975948_2976067_c" /HighExp="M0t90, M40t90, M9-stat, Lbstat, Sw, T1.30H, T1.0H, S4, S3, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.995, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1097" downshifts complement(2600315) /Source="Nicolas_upshifts" /id="D1491" /incds=0 /nref=48 /ntot=175 /MaxReadThrough="5.58383" /MaxDrop="3.85702" /score="15.0073484" /energy="-12.2" /TU="U2249" /idTUdmin="U2254" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS complement(2600392..2602131) /gene="phoR" /locus_tag="BSU_29100" /old_locus_tag="BSU29100" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:10433720, 12486063, 14762014, 15205429, 16430694, 16452408, 17085571, 20487291, 23145827, 25315493, 25355628" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10433720, 12486063, 14762014, 15205429, 16430694, 16452408, 17085571, 20487291, 23145827, 25315493, 25355628; Product type rc : receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase" /protein_id="NP_390788.1" /db_xref="EnsemblGenomes-Gn:BSU29100" /db_xref="EnsemblGenomes-Tr:CAB14870" /db_xref="GOA:P23545" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR013767" /db_xref="InterPro:IPR031967" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="PDB:3CWF" /db_xref="SubtiList:BG10364" /db_xref="UniProtKB/Swiss-Prot:P23545" /translation="MNKYRVRLFSVFVVCMILVFCVLGLFLQQLFETSDQRKAEEHIE KEAKYLASLLDAGNLNNQANEKIIKDAGGALDVSASVIDTDGKVLYGSNGRSADSQKV QALVSGHEGILSTTDNKLYYGLSLRSEGEKTGYVLLSASEKSDGLKGELWGMLTASLC TAFIVIVYFYSSMTSRYKRSIESATNVATELSKGNYDARTYGGYIRRSDKLGHAMNSL AIDLMEMTRTQEMQRDRLLTVIENIGSGLIMIDGRGFINLVNRSYAKQFHINPNHMLR RLYHDAFEHEEVIQLVEDIFMTETKKCKLLRLPIKIERRYFEVDGVPIMGPDDEWKGI VLVFHDMTETKKLEQMRKDFVANVSHELKTPITSIKGFTETLLDGAMEDKEALSEFLS IILKESERLQSLVQDLLDLSKIEQQNFTLSIETFEPAKMLGEIETLLKHKADEKGISL HLNVPKDPQYVSGDPYRLKQVFLNLVNNALTYTPEGGSVAINVKPREKDIQIEVADSG IGIQKEEIPRIFERFYRVDKDRSRNSGGTGLGLAIVKHLIEAHEGKIDVTSELGRGTV FTVTLKRAAEKSA*" /label="phoR CDS" gene complement(2600392..2602131) /gene="phoR" /locus_tag="BSU_29100" /old_locus_tag="BSU29100" /label="phoR gene" CDS complement(2602124..2602846) /gene="phoP" /locus_tag="BSU_29110" /old_locus_tag="BSU29110" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14762014, 14973033, 15205429, 16030210, 16452408, 16816204, 16980498, 17085571, 20487291, 22720735, 23145827, 25315493, 25355628" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14762014, 14973033, 15205429, 16030210, 16452408, 16816204, 16980498, 17085571, 20487291, 22720735, 23145827, 25315493, 25355628; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator" /protein_id="NP_390789.2" /db_xref="EnsemblGenomes-Gn:BSU29110" /db_xref="EnsemblGenomes-Tr:CAB14871" /db_xref="GOA:P13792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="PDB:1MVO" /db_xref="SubtiList:BG10363" /db_xref="UniProtKB/Swiss-Prot:P13792" /translation="MNKKILVVDDEESIVTLLQYNLERSGYDVITASDGEEALKKAET EKPDLIVLDVMLPKLDGIEVCKQLRQQKLMFPILMLTAKDEEFDKVLGLELGADDYMT KPFSPREVNARVKAILRRSEIAAPSSEMKNDEMEGQIVIGDLKILPDHYEAYFKESQL ELTPKEFELLLYLGRHKGRVLTRDLLLSAVWNYDFAGDTRIVDVHISHLRDKIENNTK KPIYIKTIRGLGYKLEEPKMNE*" /label="phoP CDS" gene complement(2602124..2602846) /gene="phoP" /locus_tag="BSU_29110" /old_locus_tag="BSU29110" /label="phoP gene" promotor_-10 complement(2602914..2602933) /Source="Nicolas_upshift_promotors" /id="U2249" /multdbtbs="SigA,SigA,SigE" /comp="M19" /sig="SigA" /pcomp="0.427572427572428" /psig="0.995004995004995" /xcortree=1405 /SigmaFactorBS="tttatttcttttaaaaatgatgtaaaaggcgAATTGTCggaa tgtcctgctTTCGCTAAAATAAAATCATGaaacatgttaagatgacataaaatagaga a" /listShort="phoP, phoR, S1097, polA, mutM, S1096, ytaF, coaE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2602924) /Source="Nicolas_upshifts" /id="U2249" /multdbtbs="SigA,SigA,SigE" /comp="M19" /sig="SigA" /pcomp="0.427572427572428" /psig="0.995004995004995" /xcortree=1405 /SigmaFactorBS="tttatttcttttaaaaatgatgtaaaaggcgAATTGTCggaa tgtcctgctTTCGCTAAAATAAAATCATGaaacatgttaagatgacataaaatagaga a" /listShort="phoP, phoR, S1097, polA, mutM, S1096, ytaF, coaE" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2602926..2603026) /Source="Nicolas_S_feature" /locus_tag="new_2978602_2978702_c" /HighExp="M40t90, T1.30H, T1.0H, M0t90, M9-stat, T2.0H, T2.30H, T3.0H, T0.30H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1098" promotor_-35 complement(2602947..2602953) /Source="Nicolas_upshift_promotors" /id="U2249" /multdbtbs="SigA,SigA,SigE" /comp="M19" /sig="SigA" /pcomp="0.427572427572428" /psig="0.995004995004995" /xcortree=1405 /SigmaFactorBS="tttatttcttttaaaaatgatgtaaaaggcgAATTGTCggaa tgtcctgctTTCGCTAAAATAAAATCATGaaacatgttaagatgacataaaatagaga a" /listShort="phoP, phoR, S1097, polA, mutM, S1096, ytaF, coaE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2603058..2603996) /gene="mdh" /locus_tag="BSU_29120" /old_locus_tag="BSU29120" /EC_number="1.1.1.37" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6319195, 8550482, 12034826, 16788182, 22720735, 23136871, 24325460, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6319195, 8550482, 12034826, 16788182, 22720735, 23136871, 24325460, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="malate dehydrogenase (NAD-dependent)" /protein_id="NP_390790.1" /db_xref="EnsemblGenomes-Gn:BSU29120" /db_xref="EnsemblGenomes-Tr:CAB14872" /db_xref="GOA:P49814" /db_xref="InterPro:IPR001236" /db_xref="InterPro:IPR001557" /db_xref="InterPro:IPR011275" /db_xref="InterPro:IPR015955" /db_xref="InterPro:IPR022383" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11386" /db_xref="UniProtKB/Swiss-Prot:P49814" /translation="MGNTRKKVSVIGAGFTGATTAFLIAQKELADVVLVDIPQLENPT KGKALDMLEASPVQGFDAKITGTSNYEDTAGSDIVVITAGIARKPGMSRDDLVSTNEK IMRSVTQEIVKYSPDSIIVVLTNPVDAMTYAVYKESGFPKERVIGQSGVLDTARFRTF VAEELNLSVKDVTGFVLGGHGDDMVPLVRYSYAGGIPLETLIPKERIDAIVERTRKGG GEIVNLLGNGSAYYAPAASLTEMVEAILKDQRRVLPTIAYLEGEYGYEGIYLGVPTIV GGNGLEQIIELELTDYERAQLNKSVESVKNVMKVLS*" /label="mdh CDS" gene complement(2603058..2603996) /gene="mdh" /locus_tag="BSU_29120" /old_locus_tag="BSU29120" /label="mdh gene" downshifts complement(2603071) /Source="Nicolas_upshifts" /id="D1492" /incds=0 /nref=200 /ntot=242 /MaxReadThrough="8.27126" /MaxDrop="7.40884" /score="-0.758981483" /energy="-13.5" /TU="U2251,U2254" /idTUdmin="U2250" /TUdmin="-9" /isTUend="TRUE" /label="downshifts" CDS complement(2604040..2605311) /gene="icd" /locus_tag="BSU_29130" /old_locus_tag="BSU29130" /EC_number="1.1.1.42" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8045898, 9244258, 11290745, 24325460" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045898, 9244258, 11290745, 24325460; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isocitrate dehydrogenase" /protein_id="NP_390791.1" /db_xref="EnsemblGenomes-Gn:BSU29130" /db_xref="EnsemblGenomes-Tr:CAB14873" /db_xref="GOA:P39126" /db_xref="InterPro:IPR004439" /db_xref="InterPro:IPR019818" /db_xref="InterPro:IPR024084" /db_xref="PDB:1HQS" /db_xref="SubtiList:BG10856" /db_xref="UniProtKB/Swiss-Prot:P39126" /translation="MAQGEKITVSNGVLNVPNNPIIPFIEGDGTGPDIWNAASKVLEA AVEKAYKGEKKITWKEVYAGEKAYNKTGEWLPAETLDVIREYFIAIKGPLTTPVGGGI RSLNVALRQELDLFVCLRPVRYFTGVPSPVKRPEDTDMVIFRENTEDIYAGIEYAKGS EEVQKLISFLQNELNVNKIRFPETSGIGIKPVSEEGTSRLVRAAIDYAIEHGRKSVTL VHKGNIMKFTEGAFKNWGYELAEKEYGDKVFTWAQYDRIAEEQGKDAANKAQSEAEAA GKIIIKDSIADIFLQQILTRPNEFDVVATMNLNGDYISDALAAQVGGIGIAPGANINY ETGHAIFEATHGTAPKYAGLDKVNPSSVILSGVLLLEHLGWNEAADLVIKSMEKTIAS KVVTYDFARLMDGATEVKCSEFGEELIKNMD*" /label="icd CDS" gene complement(2604040..2605311) /gene="icd" /locus_tag="BSU_29130" /old_locus_tag="BSU29130" /label="icd gene" misc_feature complement(2605096..2605115) /Source="Nicolas_upshift_promotors" /id="U2250" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.46953046953047" /psig="0.95004995004995" /xcortree=3208 /SigmaFactorBS="agcatacaaaggcgaaaagaaaattacatggaaagaagttta cgccggagaaaAGGCTTATAATAAAACAGGTgagtggctccctgctgaaacattagat g" /listShort="mdh" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2605108) /Source="Nicolas_upshifts" /id="U2250" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.46953046953047" /psig="0.95004995004995" /xcortree=3208 /SigmaFactorBS="agcatacaaaggcgaaaagaaaattacatggaaagaagttta cgccggagaaaAGGCTTATAATAAAACAGGTgagtggctccctgctgaaacattagat g" /listShort="mdh" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2605312..2605394) /Source="Nicolas_S_feature" /locus_tag="new_2980988_2981070_c" /HighExp="T2.30H, M40t90, T1.0H, T-3.40H, HiOs, T3.30H, T3.0H, T0.0H, Lbstat, T-5.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1099" upshifts complement(2605394) /Source="Nicolas_upshifts" /id="U2251" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.568431568431568" /psig=1 /xcortree=3209 /SigmaFactorBS="tgcgtcaatgaggttagccTCTTGttcagacatcaaaatTGG GTTACACTTTAAATTGAatgttaggaaaaatcattttattttctatataagaaaaata a" /listShort="S1099, icd, mdh, S1098" /listLong="phoP, phoR" /label="upshifts" S_feature complement(2605396..2605474) /Source="Nicolas_S_feature" /locus_tag="new_2981072_2981150_c" /HighExp="T2.30H, T3.30H, T1.0H, M40t90, T3.0H, Lbstat, M0t90, T0.0H, HiOs, T-0.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1100" promotor_-10 complement(2605396..2605415) /Source="Nicolas_upshift_promotors" /id="U2251" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.568431568431568" /psig=1 /xcortree=3209 /SigmaFactorBS="tgcgtcaatgaggttagccTCTTGttcagacatcaaaatTGG GTTACACTTTAAATTGAatgttaggaaaaatcattttattttctatataagaaaaata a" /listShort="S1099, icd, mdh, S1098" /listLong="phoP, phoR" /label="promotor_-10" promotor_-35 complement(2605431..2605435) /Source="Nicolas_upshift_promotors" /id="U2251" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.568431568431568" /psig=1 /xcortree=3209 /SigmaFactorBS="tgcgtcaatgaggttagccTCTTGttcagacatcaaaatTGG GTTACACTTTAAATTGAatgttaggaaaaatcattttattttctatataagaaaaata a" /listShort="S1099, icd, mdh, S1098" /listLong="phoP, phoR" /label="promotor_-35" CDS complement(2605475..2606593) /gene="citZ" /locus_tag="BSU_29140" /old_locus_tag="BSU29140" /EC_number="2.3.3.16" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8655569, 10656796, 11985717, 12100558, 19202299, 22720735, 23139400, 23354745" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8655569, 10656796, 11985717, 12100558, 19202299, 22720735, 23139400, 23354745; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="citrate synthase II" /protein_id="NP_390792.1" /db_xref="EnsemblGenomes-Gn:BSU29140" /db_xref="EnsemblGenomes-Tr:CAB14874" /db_xref="GOA:P39120" /db_xref="InterPro:IPR002020" /db_xref="InterPro:IPR011278" /db_xref="InterPro:IPR016142" /db_xref="InterPro:IPR019810" /db_xref="InterPro:IPR024176" /db_xref="InterPro:IPR036969" /db_xref="SubtiList:BG10855" /db_xref="UniProtKB/Swiss-Prot:P39120" /translation="MTATRGLEGVVATTSSVSSIIDDTLTYVGYDIDDLTENASFEEI IYLLWHLRLPNKKELEELKQQLAKEAAVPQEIIEHFKSYSLENVHPMAALRTAISLLG LLDSEADTMNPEANYRKAIRLQAKVPGLVAAFSRIRKGLEPVEPREDYGIAENFLYTL NGEEPSPIEVEAFNKALILHADHELNASTFTARVCVATLSDIYSGITAAIGALKGPLH GGANEGVMKMLTEIGEVENAEPYIRAKLEKKEKIMGFGHRVYKHGDPRAKHLKEMSKR LTNLTGESKWYEMSIRIEDIVTSEKKLPPNVDFYSASVYHSLGIDHDLFTPIFAVSRM SGWLAHILEQYDNNRLIRPRADYTGPDKQKFVPIEERA*" /label="citZ CDS" gene complement(2605475..2606593) /gene="citZ" /locus_tag="BSU_29140" /old_locus_tag="BSU29140" /label="citZ gene" downshifts 2606088 /Source="Nicolas_upshifts" /id="D1493" /incds=1 /nref=2 /ntot=63 /MaxReadThrough="1.41638" /MaxDrop="3.70762" /score="40.6931963" /energy="-9.9" /TU="NA" /idTUdmin="U2252" /TUdmin="-506" /isTUend="FALSE" /label="downshifts" misc_feature 2606435..2606438 /Source="Nicolas_upshift_promotors" /id="U2252" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.002997002997003" /xcortree=74 /SigmaFactorBS="cagcttcctttgcaagctgctgctttaactcttcaagctctt ttttgtttggCAGCcttagatgccaaagcaagtagatgatttcttcaaaacttgcatt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2606443 /Source="Nicolas_upshifts" /id="U2252" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.002997002997003" /xcortree=74 /SigmaFactorBS="cagcttcctttgcaagctgctgctttaactcttcaagctctt ttttgtttggCAGCcttagatgccaaagcaagtagatgatttcttcaaaacttgcatt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2606572 /Source="Nicolas_upshifts" /id="D1494" /incds=0 /nref=1 /ntot=126 /MaxReadThrough="2.98678" /MaxDrop="3.07929" /score="40.6931963" /energy="-9.9" /TU="U2252" /idTUdmin="U2252" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" S_feature complement(2606594..2606800) /Source="Nicolas_S_feature" /locus_tag="new_2982270_2982476_c" /HighExp="T3.0H, T3.30H, T2.30H, T4.0H, M0t90, T2.0H, T1.30H, T5.0H, BC, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1101" misc_feature 2606768..2606780 /Source="Nicolas_upshift_promotors" /id="U2253" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.467532467532468" /psig="0.464535464535465" /xcortree=721 /SigmaFactorBS="ctggaactaaaaccctttgcttttgaaagaacataacaaatt tttataaGCTTATTTAAGTTtaagcctattctcattataaacaataatcagacatttg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2606779 /Source="Nicolas_upshifts" /id="U2253" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.467532467532468" /psig="0.464535464535465" /xcortree=721 /SigmaFactorBS="ctggaactaaaaccctttgcttttgaaagaacataacaaatt tttataaGCTTATTTAAGTTtaagcctattctcattataaacaataatcagacatttg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2606786..2606805) /Source="Nicolas_upshift_promotors" /id="U2254" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=493 /SigmaFactorBS="aaatcacagaatggaaaaaaaaaattataggtaaacATTTAa caaatgtctgattATTGTTTATAATGAGAATAGgcttaaacttaaataagcttataaa a" /listShort="S1101, citZ, S1100, S1099, icd, mdh, S1098, phoP, phoR, S1097" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2606800) /Source="Nicolas_upshifts" /id="U2254" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=493 /SigmaFactorBS="aaatcacagaatggaaaaaaaaaattataggtaaacATTTAa caaatgtctgattATTGTTTATAATGAGAATAGgcttaaacttaaataagcttataaa a" /listShort="S1101, citZ, S1100, S1099, icd, mdh, S1098, phoP, phoR, S1097" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2606820..2606824) /Source="Nicolas_upshift_promotors" /id="U2254" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=493 /SigmaFactorBS="aaatcacagaatggaaaaaaaaaattataggtaaacATTTAa caaatgtctgattATTGTTTATAATGAGAATAGgcttaaacttaaataagcttataaa a" /listShort="S1101, citZ, S1100, S1099, icd, mdh, S1098, phoP, phoR, S1097" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2606920) /Source="Nicolas_upshifts" /id="D1495" /incds=0 /nref=116 /ntot=204 /MaxReadThrough="6.4946" /MaxDrop="5.00031" /score="29.3344463" /energy="-8.1" /TU="NA" /idTUdmin="U2255" /TUdmin=14 /isTUend="TRUE" /label="downshifts" CDS complement(2606927..2607391) /gene="ytwI" /locus_tag="BSU_29150" /old_locus_tag="BSU29150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_390793.1" /db_xref="EnsemblGenomes-Gn:BSU29150" /db_xref="EnsemblGenomes-Tr:CAB14875" /db_xref="GOA:O34811" /db_xref="InterPro:IPR007382" /db_xref="SubtiList:BG13933" /db_xref="UniProtKB/Swiss-Prot:O34811" /translation="MFTQANLFLILLLAIALIAKNQSLLFAVSVLLIIKIVGLDQKLF PTIQSKGINWGVTIITIAVLVPIATGEIGFKQLGEAMRSSYAWIALGAGIAVALIAKN GLTLLENDPHITTALVIGTILAVALFGGVAVGPLIGAGIAYLAMQIVKLFTS*" /label="ytwI CDS" gene complement(2606927..2607391) /gene="ytwI" /locus_tag="BSU_29150" /old_locus_tag="BSU29150" /label="ytwI gene" promotor_-10 complement(2607404..2607423) /Source="Nicolas_upshift_promotors" /id="U2255" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.774225774225774" /psig="0.774225774225774" /xcortree=1276 /SigmaFactorBS="cctcctctcgtcagcatgtcctattttttatatgTATTCACG CtgcggctgaataTGAATACATTCATCTTAAAGgagggatggcatgtgtttacacaag c" /listShort="ytwI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2607418) /Source="Nicolas_upshifts" /id="U2255" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.774225774225774" /psig="0.774225774225774" /xcortree=1276 /SigmaFactorBS="cctcctctcgtcagcatgtcctattttttatatgTATTCACG CtgcggctgaataTGAATACATTCATCTTAAAGgagggatggcatgtgtttacacaag c" /listShort="ytwI" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2607420..2608605) /Source="Nicolas_S_feature" /locus_tag="new_2983096_2984281_c" /HighExp="G135, G180, LBGstat, G150, LBGtran, S0, Paraq, Oxctl, H2O2, LBGexp" /AntisenseName="ytvI" /AntisenseCor="-0.73323145377324295" /AntisenseRegPval="-45.9" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1102" promotor_-35 2607420..2607425 /Source="Nicolas_upshift_promotors" /id="U2256" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=994 /SigmaFactorBS="aaacacatgccatccctcctttaagatgaatgtaTTCATAtt cagccgcagcgtGAATACATATAAAAAATAGgacatgctgacgagaggaggaccgttt t" /listShort="ytvI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2607436..2607444) /Source="Nicolas_upshift_promotors" /id="U2255" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.774225774225774" /psig="0.774225774225774" /xcortree=1276 /SigmaFactorBS="cctcctctcgtcagcatgtcctattttttatatgTATTCACG CtgcggctgaataTGAATACATTCATCTTAAAGgagggatggcatgtgtttacacaag c" /listShort="ytwI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2607440..2607458 /Source="Nicolas_upshift_promotors" /id="U2256" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=994 /SigmaFactorBS="aaacacatgccatccctcctttaagatgaatgtaTTCATAtt cagccgcagcgtGAATACATATAAAAAATAGgacatgctgacgagaggaggaccgttt t" /listShort="ytvI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2607446 /Source="Nicolas_upshifts" /id="U2256" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=994 /SigmaFactorBS="aaacacatgccatccctcctttaagatgaatgtaTTCATAtt cagccgcagcgtGAATACATATAAAAAATAGgacatgctgacgagaggaggaccgttt t" /listShort="ytvI" /GFF_Attribute="listLong" /label="upshifts" CDS 2607488..2608603 /gene="ytvI" /locus_tag="BSU_29160" /old_locus_tag="BSU29160" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12662922, 15849754, 16850406, 26735940; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sporulation-related permease" /protein_id="NP_390794.1" /db_xref="EnsemblGenomes-Gn:BSU29160" /db_xref="EnsemblGenomes-Tr:CAB14876" /db_xref="GOA:O34991" /db_xref="InterPro:IPR002549" /db_xref="InterPro:IPR014227" /db_xref="SubtiList:BG13930" /db_xref="UniProtKB/Swiss-Prot:O34991" /translation="MNQSYITIFFRTLFVISMTAGSIAAAYYSFPLTYPFLIALILSS VIHPVVDYLDKVTGFPRTINVLGVLAFFLLAAFGVLTILVAEIVTGTAYLAKTLPPHI STFISYCEKLFTTHIQPLYNELTLLFQELETNQQASIVTHIQTLGDSAAKNAGLLLSH ILEMIPRFFALLPNTAAVLIFSLLATFFMTKDWHKLKAMLVLILPDRVTANSKAISSE LKKAMTGFIKAQAVLVFITMVIVFIGLSLLKVEHAATIAFLIGLVDLLPYLGAGSVFV PWILYLSITGQLPQAIGIGILYLVVLIQRQLTEPKILSKSIGIDPLATLIALFAGFKL FGFLGLIAGPAVLVIIQAFITTGALKEIWSYITVQQK*" /label="ytvI CDS" gene 2607488..2608603 /gene="ytvI" /locus_tag="BSU_29160" /old_locus_tag="BSU29160" /label="ytvI gene" downshifts 2608574 /Source="Nicolas_upshifts" /id="D1496" /incds=0 /nref=2 /ntot=24 /MaxReadThrough="1.639" /MaxDrop="3.31897" /score="37.6858539" /energy="-16.7" /TU="NA" /idTUdmin="U2256" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2608636..2609019) /gene="ytzA" /locus_tag="BSU_29170" /old_locus_tag="BSU29170" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15302217, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390795.1" /db_xref="EnsemblGenomes-Gn:BSU29170" /db_xref="EnsemblGenomes-Tr:CAB14877" /db_xref="GOA:O32064" /db_xref="InterPro:IPR007313" /db_xref="SubtiList:BG13935" /db_xref="UniProtKB/Swiss-Prot:O32064" /translation="MRFLFLLFIVFPAIEIGIFLFLGNLIGILPTVLFMILTGIIGAA AAKKQGTEVYYKVQRDLQYGKMPGEAIADGLCIFIGGLLLMLPGFLSDLAGACLLIPF TRGWCKPILFKWLRGMSKNKRIIIK*" /label="ytzA CDS" gene complement(2608636..2609019) /gene="ytzA" /locus_tag="BSU_29170" /old_locus_tag="BSU29170" /label="ytzA gene" downshifts complement(2608650) /Source="Nicolas_upshifts" /id="D1497" /incds=0 /nref=181 /ntot=256 /MaxReadThrough="4.28884" /MaxDrop="5.74703" /score="18.319512" /energy="-13.8" /TU="NA" /idTUdmin="U2257" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2609020..2609111) /Source="Nicolas_S_feature" /locus_tag="new_2984696_2984787_c" /HighExp="G135, LBGtran, G150, LBGexp, M0t45, Lbexp, S0, G180, Oxctl, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 1" /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S1103" CDS complement(2609112..2610869) /gene="pyk" /locus_tag="BSU_29180" /old_locus_tag="BSU29180" /EC_number="2.7.1.40" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10559165, 10932722, 10966427, 11489127, 17022686, 18586936, 22846916, 24825009" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10559165, 10932722, 10966427, 11489127, 17022686, 18586936, 22846916, 24825009; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyruvate kinase" /protein_id="NP_390796.1" /db_xref="EnsemblGenomes-Gn:BSU29180" /db_xref="EnsemblGenomes-Tr:CAB14878" /db_xref="GOA:P80885" /db_xref="InterPro:IPR001697" /db_xref="InterPro:IPR008279" /db_xref="InterPro:IPR011037" /db_xref="InterPro:IPR015793" /db_xref="InterPro:IPR015795" /db_xref="InterPro:IPR015813" /db_xref="InterPro:IPR018209" /db_xref="InterPro:IPR036918" /db_xref="SubtiList:BG12661" /db_xref="UniProtKB/Swiss-Prot:P80885" /translation="MRKTKIVCTIGPASESIEMLTKLMESGMNVARLNFSHGDFEEHG ARIKNIREASKKLGKNVGILLDTKGPEIRTHTMENGGIELETGKELIISMDEVVGTTD KISVTYEGLVHDVEQGSTILLDDGLIGLEVLDVDAAKREIKTKVLNNGTLKNKKGVNV PGVSVNLPGITEKDARDIVFGIEQGVDFIAPSFIRRSTDVLEIRELLEEHNAQDIQII PKIENQEGVDNIDAILEVSDGLMVARGDLGVEIPAEEVPLVQKELIKKCNALGKPVIT ATQMLDSMQRNPRPTRAEASDVANAIFDGTDAIMLSGETAAGSYPVEAVQTMHNIASR SEEALNYKEILSKRRDQVGMTITDAIGQSVAHTAINLNAAAIVTPTESGHTARMIAKY RPQAPIVAVTVNDSISRKLALVSGVFAESGQNASSTDEMLEDAVQKSLNSGIVKHGDL IVITAGTVGESGTTNLMKVHTVGDIIAKGQGIGRKSAYGPVVVAQNAKEAEQKMTDGA VLVTKSTDRDMIASLEKASALITEEGGLTSHAAVVGLSLGIPVIVGLENATSILTDGQ DITVDASRGAVYQGRASVL*" /label="pyk CDS" gene complement(2609112..2610869) /gene="pyk" /locus_tag="BSU_29180" /old_locus_tag="BSU29180" /label="pyk gene" CDS complement(2610912..2611871) /gene="pfkA" /locus_tag="BSU_29190" /old_locus_tag="BSU29190" /EC_number="2.7.1.11" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12450869, 12622823, 12682299, 19193632, 20473954, 22198292" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12450869, 12622823, 12682299, 19193632, 20473954, 22198292; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="6-phosphofructokinase" /protein_id="NP_390797.1" /db_xref="EnsemblGenomes-Gn:BSU29190" /db_xref="EnsemblGenomes-Tr:CAB14879" /db_xref="GOA:O34529" /db_xref="InterPro:IPR000023" /db_xref="InterPro:IPR012003" /db_xref="InterPro:IPR012828" /db_xref="InterPro:IPR015912" /db_xref="InterPro:IPR022953" /db_xref="InterPro:IPR035966" /db_xref="PDB:4A3S" /db_xref="SubtiList:BG12644" /db_xref="UniProtKB/Swiss-Prot:O34529" /translation="MKRIGVLTSGGDSPGMNAAVRAVVRKAIYHDVEVYGIYNGYAGL ISGKIEKLELGSVGDIIHRGGTKLYTARCPEFKTVEGREKGIANLKKLGIEGLVVIGG DGSYMGAKKLTEHGFPCVGVPGTIDNDIPGTDFTIGFDTALNTVIDAIDKIRDTATSH ERTYVIEVMGRHAGDIALWAGLAGGAESILIPEADYDMHEIIARLKRGHERGKKHSII IVAEGVGSGVEFGKRIEEETNLETRVSVLGHIQRGGSPSAADRVLASRLGAYAVELLL EGKGGRCVGIQNNKLVDHDIIEILETKHTVEQNMYQLSKELSI*" /label="pfkA CDS" gene complement(2610912..2611871) /gene="pfkA" /locus_tag="BSU_29190" /old_locus_tag="BSU29190" /label="pfkA gene" S_feature complement(2611872..2611973) /Source="Nicolas_S_feature" /locus_tag="new_2987548_2987649_c" /HighExp="G150, LBGtran, LBGexp, Lbexp, dia0, G180, G135, Oxctl, LBGstat, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 1" /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S1104" promotor_-10 complement(2611962..2611981) /Source="Nicolas_upshift_promotors" /id="U2257" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2698 /SigmaFactorBS="cacgtttattttttgtgacattccttaaatttTATTTaaaaa caatttatttAATTGTATAATAGGTAAGGTttcatagggaggatggagatcccttttc a" /listShort="S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2611973) /Source="Nicolas_upshifts" /id="U2257" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2698 /SigmaFactorBS="cacgtttattttttgtgacattccttaaatttTATTTaaaaa caatttatttAATTGTATAATAGGTAAGGTttcatagggaggatggagatcccttttc a" /listShort="S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2611997..2612001) /Source="Nicolas_upshift_promotors" /id="U2257" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2698 /SigmaFactorBS="cacgtttattttttgtgacattccttaaatttTATTTaaaaa caatttatttAATTGTATAATAGGTAAGGTttcatagggaggatggagatcccttttc a" /listShort="S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2612055..2613032) /gene="accA" /locus_tag="BSU_29200" /old_locus_tag="BSU29200" /EC_number="6.4.1.2" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11133475, 12682299, 15066985; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-CoA carboxylase (carboxyltransferase alpha subunit)" /protein_id="NP_390798.1" /db_xref="EnsemblGenomes-Gn:BSU29200" /db_xref="EnsemblGenomes-Tr:CAB14880" /db_xref="GOA:O34847" /db_xref="InterPro:IPR001095" /db_xref="InterPro:IPR011763" /db_xref="InterPro:IPR029045" /db_xref="SubtiList:BG12557" /db_xref="UniProtKB/Swiss-Prot:O34847" /translation="MAPRLEFEKPVIELQTKIAELKKFTQDSDMDLSAEIERLEDRLA KLQDDIYKNLKPWDRVQIARLADRPTTLDYIEHLFTDFFECHGDRAYGDDEAIVGGIA KFHGLPVTVIGHQRGKDTKENLVRNFGMPHPEGYRKALRLMKQADKFNRPIICFIDTK GAYPGRAAEERGQSEAIAKNLFEMAGLRVPVICIVIGEGGSGGALGLGVGNHLHMLEN STYSVISPEGAAALLWKDSSLAKKAAETMKITAPDLKELGIIDHMIKEVKGGAHHDVK LQASYMDETLKQSLKTLLKLSEEELVQQRYEKYKAIGKVSVEDQYIGVN*" /label="accA CDS" gene complement(2612055..2613032) /gene="accA" /locus_tag="BSU_29200" /old_locus_tag="BSU29200" /label="accA gene" downshifts complement(2612082) /Source="Nicolas_upshifts" /id="D1498" /incds=0 /nref=48 /ntot=176 /MaxReadThrough="5.40549" /MaxDrop="5.53933" /score="-3.96100458" /energy="-6.8" /TU="U2259,U2260,U2262,U2263" /idTUdmin="U2260" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" CDS complement(2613017..2613889) /gene="accD" /locus_tag="BSU_29210" /old_locus_tag="BSU29210" /EC_number="6.4.1.2" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11133475, 12682299, 14594796, 15066985; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-CoA carboxylase (carboxyltransferase betasubunit)" /protein_id="NP_390799.2" /db_xref="EnsemblGenomes-Gn:BSU29210" /db_xref="EnsemblGenomes-Tr:CAB14881" /db_xref="GOA:C0SP93" /db_xref="InterPro:IPR000438" /db_xref="InterPro:IPR011762" /db_xref="InterPro:IPR029045" /db_xref="InterPro:IPR034733" /db_xref="SubtiList:BG13926" /db_xref="UniProtKB/Swiss-Prot:C0SP93" /translation="MLKDIFTKKKKYASVPSDQAKHDVPEGIMTKCPKCKKIMLTKEL DKNMRVCMNCDYHFPMNAKQRIESLMDEQSFEEFNQGMLSENPLGFPGYLEKLEKDRE KTSLNEAVVTGKGTIGGHPAVVAVMDSSFRMGSMGSVVGEKITLAIEKAKADKVPFII FTASGGARMQEGVLSLMQMAKTSSALKLFSEEQGLIISVMTHPTTGGVSASFASLGDY NFAEPGALIGFAGRRIIEQTIGEKLPEDFQTAEFLLKHGQLDAVIHRDDMKKTLENLL DMHQTGGDIEWLQD*" /label="accD CDS" gene complement(2613017..2613889) /gene="accD" /locus_tag="BSU_29210" /old_locus_tag="BSU29210" /label="accD gene" promotor_-35 2613851..2613856 /Source="Nicolas_upshift_promotors" /id="U2258" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1067 /SigmaFactorBS="ggaacatcgtgcttcgcttgatcagacggtacggaAGCATAc tttttctttttcgtGAATATATCCTTTAACAAAtgattacctcccttttgtgaagggt t" /listShort="S1105" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2613872..2613890 /Source="Nicolas_upshift_promotors" /id="U2258" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1067 /SigmaFactorBS="ggaacatcgtgcttcgcttgatcagacggtacggaAGCATAc tttttctttttcgtGAATATATCCTTTAACAAAtgattacctcccttttgtgaagggt t" /listShort="S1105" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2613876..2615050 /Source="Nicolas_S_feature" /locus_tag="new_2989552_2990726" /HighExp="S5, S8, S6, S7, C30, S4, C90, S3, T5.0H, BC" /AntisenseName="ytsJ" /AntisenseCor="-0.46008986922877199" /AntisenseRegPval="-14.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1105" upshifts 2613876 /Source="Nicolas_upshifts" /id="U2258" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1067 /SigmaFactorBS="ggaacatcgtgcttcgcttgatcagacggtacggaAGCATAc tttttctttttcgtGAATATATCCTTTAACAAAtgattacctcccttttgtgaagggt t" /listShort="S1105" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2613890..2613973) /Source="Nicolas_S_feature" /locus_tag="new_2989566_2989649_c" /HighExp="LBGstat, T4.0H, LBGtran, T5.0H, C30, dia15, M9-stat, Oxctl, LBGexp, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="1, 1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1106" promotor_-10 complement(2613962..2613981) /Source="Nicolas_upshift_promotors" /id="U2259" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.675324675324675" /psig=1 /xcortree=2509 /SigmaFactorBS="gcacgtcatcgaataaaaagttgtcgaattgaGGATGacagc gtttgacaaaAAAAGTACAATAGTTTCGGTaaagttattagcaagtctatctgtttga t" /listShort="S1106, accD, accA, S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2613973) /Source="Nicolas_upshifts" /id="U2259" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.675324675324675" /psig=1 /xcortree=2509 /SigmaFactorBS="gcacgtcatcgaataaaaagttgtcgaattgaGGATGacagc gtttgacaaaAAAAGTACAATAGTTTCGGTaaagttattagcaagtctatctgtttga t" /listShort="S1106, accD, accA, S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2613975..2614127) /Source="Nicolas_S_feature" /locus_tag="new_2989651_2989803_c" /HighExp="Diami, BC, dia15, Sw, dia5, M40t90, H2O2, S2, G/S, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1107" promotor_-35 complement(2613997..2614001) /Source="Nicolas_upshift_promotors" /id="U2259" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.675324675324675" /psig=1 /xcortree=2509 /SigmaFactorBS="gcacgtcatcgaataaaaagttgtcgaattgaGGATGacagc gtttgacaaaAAAAGTACAATAGTTTCGGTaaagttattagcaagtctatctgtttga t" /listShort="S1106, accD, accA, S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2614129..2614223) /Source="Nicolas_S_feature" /locus_tag="new_2989805_2989899_c" /HighExp="dia15, LBGtran, LBGstat, Diami, LoTm, C90, GM 120, MG 60, M/G, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1108" downshifts complement(2614172) /Source="Nicolas_upshifts" /id="D1499" /incds=0 /nref=52 /ntot=158 /MaxReadThrough="7.72399" /MaxDrop="4.5863" /score="-3.96100458" /energy="-6.8" /TU="U2260,U2262,U2263" /idTUdmin="U2260" /TUdmin="-2178" /isTUend="FALSE" /label="downshifts" CDS complement(2614224..2615456) /gene="maeB" /locus_tag="BSU_29220" /old_locus_tag="BSU29220" /EC_number="1.1.1.40" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:16788182, 22740702, 23136871, 24325460, 25393291" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16788182, 22740702, 23136871, 24325460, 25393291; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADP-dependent malic enzyme (conversion of malate into pyruvate, anabolic)" /protein_id="NP_390800.1" /db_xref="EnsemblGenomes-Gn:BSU29220" /db_xref="EnsemblGenomes-Tr:CAB14882" /db_xref="GOA:O34962" /db_xref="InterPro:IPR001891" /db_xref="InterPro:IPR012301" /db_xref="InterPro:IPR012302" /db_xref="InterPro:IPR015884" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR037062" /db_xref="SubtiList:BG13922" /db_xref="UniProtKB/Swiss-Prot:O34962" /translation="MSLREEALHLHKVNQGKLESKSKVEVRNAKDLSLAYSPGVAEPC KDIHEDINKVYDYTMKGNMVAVVTDGTAVLGLGNIGPEAALPVMEGKAVLFKSFAGVD AFPIALNTNDVDKIVETVKLLEPTFGGVNLEDIAAPNCFIIEERLKKETNIPVFHDDQ HGTAIVTVAGLVNALKLSGKSMSSIKVVANGAGAAGIAIIKLLHHYGVRDIVMCDSKG AIYEGRPNGMNDVKNEVAKFTNQDRKDGSLKDVIVDADVFIGVSVAGALTKEMVQSMA KDPIIFAMANPNPEIMPEDAREAGASVVGTGRSDFPNQVNNVLAFPGIFRGALDVRAT HINEEMKIAAVEAIASLVSEDELSADYVIPAPFDKRVAPAVAKAVAKAAMETGVARIT VDPEEVAEKTRKLTIIGE*" /label="maeB CDS" gene complement(2614224..2615456) /gene="maeB" /locus_tag="BSU_29220" /old_locus_tag="BSU29220" /label="maeB gene" S_feature complement(2615457..2615573) /Source="Nicolas_S_feature" /locus_tag="new_2991133_2991249_c" /HighExp="dia15, Diami, LBGstat, H2O2, LBGtran, dia5, M40t45, Lbtran, LPhT, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1109" promotor_-10 complement(2615561..2615580) /Source="Nicolas_upshift_promotors" /id="U2260" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=1981 /SigmaFactorBS="agctgttgggtcaaaaaaacgtcgttttaaaaCAGTGGTAac gattcgcttttTGTTATACAATTGGAGCAATtatgtgatcctgtttaaatattcagat a" /listShort="S1109, ytsJ, S1108, S1107, S1106, accD, accA" /listLong="S1104, pfkA, pyk, S1103, ytzA" /label="promotor_-10" upshifts complement(2615573) /Source="Nicolas_upshifts" /id="U2260" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=1981 /SigmaFactorBS="agctgttgggtcaaaaaaacgtcgttttaaaaCAGTGGTAac gattcgcttttTGTTATACAATTGGAGCAATtatgtgatcctgtttaaatattcagat a" /listShort="S1109, ytsJ, S1108, S1107, S1106, accD, accA" /listLong="S1104, pfkA, pyk, S1103, ytzA" /label="upshifts" CDS complement(2615593..2618940) /gene="dnaEC" /locus_tag="BSU_29230" /old_locus_tag="BSU29230" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:9799485, 9822387, 10354411, 14593098, 20122408, 22333191, 24106089, 29078353" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9799485, 9822387, 10354411, 14593098, 20122408, 22333191, 24106089, 29078353; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase III (alpha subunit), DnaE3" /protein_id="NP_390801.1" /db_xref="EnsemblGenomes-Gn:BSU29230" /db_xref="EnsemblGenomes-Tr:CAB14883" /db_xref="GOA:O34623" /db_xref="InterPro:IPR003141" /db_xref="InterPro:IPR004013" /db_xref="InterPro:IPR004365" /db_xref="InterPro:IPR004805" /db_xref="InterPro:IPR011708" /db_xref="InterPro:IPR016195" /db_xref="InterPro:IPR029460" /db_xref="SubtiList:BG12583" /db_xref="UniProtKB/Swiss-Prot:O34623" /translation="MSFVHLQVHSGYSLLNSAAAVEELVSEADRLGYASLALTDDHVM YGAIQFYKACKARGINPIIGLTASVFTDDSELEAYPLVLLAKSNTGYQNLLKISSVLQ SKSKGGLKPKWLHSYREGIIAITPGEKGYIETLLEGGLFEQAAQASLEFQSIFGKGAF YFSYQPFKGNQVLSEQILKLSEETGIPVTATGDVHYIRKEDKAAYRCLKAIKAGEKLT DAPAEDLPDLDLKPLEEMQNIYREHPEALQASVEIAEQCRVDVSLGQTRLPSFPTPDG TSADDYLTDICMEGLRSRFGKPDERYLRRLQYELDVIKRMKFSDYFLIVWDFMKHAHE KGIVTGPGRGSAAGSLVAYVLYITDVDPIKHHLLFERFLNPERVSMPDIDIDFPDTRR DEVIQYVQQKYGAMHVAQIITFGTLAAKAALRDVGRVFGVSPKEADQLAKLIPSRPGM TLDEARQQSPQLDKRLRESSLLQQVYSIARKIEGLPRHASTHAAGVVLSEEPLTDVVP LQEGHEGIYLTQYAMDHLEDLGLLKMDFLGLRNLTLIESITSMIEKEENIKIDLSSIS YSDDKTFSLLSKGDTTGIFQLESAGMRSVLKRLKPSGLEDIVAVNALYRPGPMENIPL FIDRKHGRAPVHYPHEDLRSILEDTYGVIVYQEQIMMIASRMAGFSLGEADLLRRAVS KKKKEILDRERSHFVEGCLKKEYSVDTANEVYDLIVKFANYGFNRSHAVAYSMIGCQL AYLKAHYPLYFMCGLLTSVIGNEDKISQYLYEAKGSGIRILPPSVNKSSFPFTVENGS VRYSLRAIKSVGVSAVKDIYKARKEKPFEDLFDFCFRVPSKSVNRKMLEALIFSGAMD EFGQNRATLLASIDVALEHAELFAADDDQMGLFLDESFSIKPKYVETEELPLVDLLAF EKETLGIYFSNHPLSAFRKQLTAQGAVSILQAQRAVKRQLSLGVLLSKIKTIRTKTGQ NMAFLTLSDETGEMEAVVFPEQFRQLSPVLREGALLFTAGKCEVRQDKIQFIMSRAEL LEDMDAEKAPSVYIKIESSQHSQEILAKIKRILLEHKGETGVYLYYERQKQTIKLPES FHINADHQVLYRLKELLGQKNVVLKQW*" /label="dnaEC CDS" gene complement(2615593..2618940) /gene="dnaEC" /locus_tag="BSU_29230" /old_locus_tag="BSU29230" /label="dnaEC gene" promotor_-35 complement(2615594..2615601) /Source="Nicolas_upshift_promotors" /id="U2260" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=1981 /SigmaFactorBS="agctgttgggtcaaaaaaacgtcgttttaaaaCAGTGGTAac gattcgcttttTGTTATACAATTGGAGCAATtatgtgatcctgtttaaatattcagat a" /listShort="S1109, ytsJ, S1108, S1107, S1106, accD, accA" /listLong="S1104, pfkA, pyk, S1103, ytzA" /label="promotor_-35" promotor_-35 2616605..2616614 /Source="Nicolas_upshift_promotors" /id="U2261" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1681 /SigmaFactorBS="aacggaaaactgcttttattcactgacggaggaaggataCGA ATCCCGCtcccctttgctTCGTAAAGATATTGAGagattttatcctcattgccaatga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2616626..2616641 /Source="Nicolas_upshift_promotors" /id="U2261" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1681 /SigmaFactorBS="aacggaaaactgcttttattcactgacggaggaaggataCGA ATCCCGCtcccctttgctTCGTAAAGATATTGAGagattttatcctcattgccaatga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2616626 /Source="Nicolas_upshifts" /id="U2261" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1681 /SigmaFactorBS="aacggaaaactgcttttattcactgacggaggaaggataCGA ATCCCGCtcccctttgctTCGTAAAGATATTGAGagattttatcctcattgccaatga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2616814..2616833) /Source="Nicolas_upshift_promotors" /id="U2262" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=2017 /SigmaFactorBS="aaaagaaaaaagaaatcctggacagagagcgaagccattTTG TTGAAgggtgcttaaaaaAGGAGTATTCTGTAGACACTgcaaatgaggtctacgattt a" /listShort="S1109, ytsJ, S1108, S1107, S1106, accD, accA, S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2616833) /Source="Nicolas_upshifts" /id="U2262" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=2017 /SigmaFactorBS="aaaagaaaaaagaaatcctggacagagagcgaagccattTTG TTGAAgggtgcttaaaaaAGGAGTATTCTGTAGACACTgcaaatgaggtctacgattt a" /listShort="S1109, ytsJ, S1108, S1107, S1106, accD, accA, S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2616847..2616854) /Source="Nicolas_upshift_promotors" /id="U2262" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=2017 /SigmaFactorBS="aaaagaaaaaagaaatcctggacagagagcgaagccattTTG TTGAAgggtgcttaaaaaAGGAGTATTCTGTAGACACTgcaaatgaggtctacgattt a" /listShort="S1109, ytsJ, S1108, S1107, S1106, accD, accA, S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2618971..2618990) /Source="Nicolas_upshift_promotors" /id="U2263" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2091 /SigmaFactorBS="agctttcaggacaagtatgatgatgagtcaaaaaagaaCATT TGTTtcttttggaaaccGGCCTTATAATGAAGGAAGAaatggatcgtaatgagaaaga g" /listShort="dnaE, S1109, ytsJ, S1108, S1107, S1106, accD, accA" /listLong="S1104, pfkA, pyk, S1103, ytzA" /label="promotor_-10" upshifts complement(2618989) /Source="Nicolas_upshifts" /id="U2263" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2091 /SigmaFactorBS="agctttcaggacaagtatgatgatgagtcaaaaaagaaCATT TGTTtcttttggaaaccGGCCTTATAATGAAGGAAGAaatggatcgtaatgagaaaga g" /listShort="dnaE, S1109, ytsJ, S1108, S1107, S1106, accD, accA" /listLong="S1104, pfkA, pyk, S1103, ytzA" /label="upshifts" promotor_-35 complement(2619004..2619011) /Source="Nicolas_upshift_promotors" /id="U2263" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2091 /SigmaFactorBS="agctttcaggacaagtatgatgatgagtcaaaaaagaaCATT TGTTtcttttggaaaccGGCCTTATAATGAAGGAAGAaatggatcgtaatgagaaaga g" /listShort="dnaE, S1109, ytsJ, S1108, S1107, S1106, accD, accA" /listLong="S1104, pfkA, pyk, S1103, ytzA" /label="promotor_-35" promotor_-35 2619029..2619034 /Source="Nicolas_upshift_promotors" /id="U2264" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=988 /SigmaFactorBS="aggccggtttccaaaagaaacaaatgttcttttttgactcat cATCATActtgtcctgaaagctCAATATGATATAAAAGGTGaggtgataaagatggat c" /listShort="ytrH, ytrI" /listLong="ytzJ, S1110, S1111, S1112, ytpI, S1114" /label="promotor_-35" upshifts 2619046 /Source="Nicolas_upshifts" /id="U2264" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=988 /SigmaFactorBS="aggccggtttccaaaagaaacaaatgttcttttttgactcat cATCATActtgtcctgaaagctCAATATGATATAAAAGGTGaggtgataaagatggat c" /listShort="ytrH, ytrI" /listLong="ytzJ, S1110, S1111, S1112, ytpI, S1114" /label="upshifts" promotor_-10 2619050..2619068 /Source="Nicolas_upshift_promotors" /id="U2264" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=988 /SigmaFactorBS="aggccggtttccaaaagaaacaaatgttcttttttgactcat cATCATActtgtcctgaaagctCAATATGATATAAAAGGTGaggtgataaagatggat c" /listShort="ytrH, ytrI" /listLong="ytzJ, S1110, S1111, S1112, ytpI, S1114" /label="promotor_-10" CDS 2619080..2619421 /gene="ytrH" /locus_tag="BSU_29239" /old_locus_tag="BSU29239" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12662922, 15547282, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12662922, 15547282, 26735940; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="membrane protein involved in a sporulation process" /protein_id="YP_003097771.1" /db_xref="EnsemblGenomes-Gn:BSU29239" /db_xref="EnsemblGenomes-Tr:CAX52677" /db_xref="GOA:C0H3P8" /db_xref="InterPro:IPR025689" /db_xref="UniProtKB/Swiss-Prot:C0H3P8" /translation="MDQEAGFMVNFINSYFIALGVLIGGALIGGLGAYLAGEPPLTAI TKLANRLKIWALVAAIGGTFDAVYSFERGILEGNTRDIFKQLLLIISAMGGAQSGWLI ISWLTQEHLSS*" /label="ytrH CDS" gene 2619080..2619421 /gene="ytrH" /locus_tag="BSU_29239" /old_locus_tag="BSU29239" /label="ytrH gene" CDS 2619418..2619921 /gene="ytrI" /locus_tag="BSU_29240" /old_locus_tag="BSU29240" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12662922, 15547282, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12662922, 15547282, 26735940; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="protein involved in sporulation" /protein_id="NP_390802.3" /db_xref="EnsemblGenomes-Gn:BSU29240" /db_xref="EnsemblGenomes-Tr:CAB14884" /db_xref="GOA:O34460" /db_xref="SubtiList:BG13917" /db_xref="UniProtKB/Swiss-Prot:O34460" /translation="MRVPQHYKKPGWQRFFAGMMCGAVISWFFFLFTYGTFQEEQVSL IEKQKEHVKDLNNQISIYQEDLHKLNEDNKRKLLIQSVSVKLLNGDKYKISQPDKTKF EEHVKDDISEVITKDIESVYQTKDLLKRTIENKVYMINEKKYEATVRELIIYTRLTVE LEISFAT*" /label="ytrI CDS" gene 2619418..2619921 /gene="ytrI" /locus_tag="BSU_29240" /old_locus_tag="BSU29240" /label="ytrI gene" promotor_-35 2619954..2619957 /Source="Nicolas_upshift_promotors" /id="U2265" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.487512487512487" /psig="0.973026973026973" /xcortree=529 /SigmaFactorBS="cgccacataattatggattttttttaaattctccaaacttct GTCGctttttcccattctTTTTTATAAACTATATGTGAggcttaatggcgaaaggaag g" /listShort="ytzJ, S1110, S1111, S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2619972..2619991 /Source="Nicolas_upshift_promotors" /id="U2265" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.487512487512487" /psig="0.973026973026973" /xcortree=529 /SigmaFactorBS="cgccacataattatggattttttttaaattctccaaacttct GTCGctttttcccattctTTTTTATAAACTATATGTGAggcttaatggcgaaaggaag g" /listShort="ytzJ, S1110, S1111, S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2619972 /Source="Nicolas_upshifts" /id="U2265" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.487512487512487" /psig="0.973026973026973" /xcortree=529 /SigmaFactorBS="cgccacataattatggattttttttaaattctccaaacttct GTCGctttttcccattctTTTTTATAAACTATATGTGAggcttaatggcgaaaggaag g" /listShort="ytzJ, S1110, S1111, S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="upshifts" CDS 2620023..2620214 /gene="ytzJ" /locus_tag="BSU_29249" /old_locus_tag="BSU29249" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative sporulation-related conserved protein" /protein_id="YP_003097772.1" /db_xref="EnsemblGenomes-Gn:BSU29249" /db_xref="EnsemblGenomes-Tr:CAX52678" /db_xref="UniProtKB/Swiss-Prot:C0H3P9" /translation="MEVYSDRQLAKDQAARLRQGFSAYAETNSLASLIKKELQSHNLQ VYEDLTDFGCWFIPVTDEH*" /label="ytzJ CDS" gene 2620023..2620214 /gene="ytzJ" /locus_tag="BSU_29249" /old_locus_tag="BSU29249" /label="ytzJ gene" downshifts complement(2620024) /Source="Nicolas_upshifts" /id="D1500" /incds=0 /nref=1 /ntot=5 /MaxReadThrough="2.45109" /MaxDrop="3.19151" /score="-1.37123732" /energy="-6.5" /TU="NA" /idTUdmin="U2268" /TUdmin=220 /isTUend="FALSE" /label="downshifts" downshifts 2620190 /Source="Nicolas_upshifts" /id="D1501" /incds=0 /nref=15 /ntot=107 /MaxReadThrough="6.88261" /MaxDrop="6.74738" /score="-8.58003897" /energy="-4" /TU="U2265" /idTUdmin="U2264" /TUdmin=242 /isTUend="FALSE" /label="downshifts" CDS complement(2620232..2621173) /gene="nrnA" /locus_tag="BSU_29250" /old_locus_tag="BSU29250" /EC_number="3.1.3.7" /EC_number="3.1.-.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17586819, 19553197, 22102036, 26735940, 28894100" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17586819, 19553197, 22102036, 26735940, 28894100; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nanoRNase (oligoribonuclease) (3'->5'short substrates, 5'->3' long substrates), 3',5'-bisphosphate nucleotidase" /protein_id="NP_390803.1" /db_xref="EnsemblGenomes-Gn:BSU29250" /db_xref="EnsemblGenomes-Tr:CAB14885" /db_xref="GOA:O34600" /db_xref="InterPro:IPR001667" /db_xref="InterPro:IPR003156" /db_xref="PDB:5IPP" /db_xref="PDB:5IUF" /db_xref="PDB:5IZO" /db_xref="PDB:5J21" /db_xref="SubtiList:BG13910" /db_xref="UniProtKB/Swiss-Prot:O34600" /translation="MKTELIRTISLYDTIILHRHVRPDPDAYGSQCGLTEILRETYPE KNIFAVGTPEPSLSFLYSLDEVDNETYEGALVIVCDTANQERIDDQRYPSGAKLMKID HHPNEDPYGDLLWVDTSASSVSEMIYELYLEGKEHGWKLNTKAAELIYAGIVGDTGRF LFPNTTEKTLKYAGELIQYPFSSSELFNQLYETKLNVVKLNGFIFQNVSLSENGAASV FIKKDTLEKFGTTASEASQLVGTLGNISGIRAWVFFVEEDDQIRVRFRSKGPVINGLA RKYNGGGHPLASGASIYSWDEADRILADLETLCKEHE*" /label="nrnA CDS" gene complement(2620232..2621173) /gene="nrnA" /locus_tag="BSU_29250" /old_locus_tag="BSU29250" /label="nrnA gene" S_feature 2620235..2620606 /Source="Nicolas_S_feature" /locus_tag="new_2995911_2996282" /HighExp="Lbstat, S2, M0t90, M40t90, nit, ferm, S3, BT, M9-stat, S0" /AntisenseName="nrnA" /AntisenseCor="-0.77648424268923499" /AntisenseRegPval="-54.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.973" /TUlongSig="SigEF" /TUlongPSig="0.994" /label="S1110" downshifts complement(2620267) /Source="Nicolas_upshifts" /id="D1502" /incds=0 /nref=25 /ntot=163 /MaxReadThrough="3.12169" /MaxDrop="3.09205" /score="22.5196409" /energy="-7.9" /TU="U2268" /idTUdmin="U2269" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 2620575..2620584 /Source="Nicolas_upshift_promotors" /id="U2266" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1354 /SigmaFactorBS="gacacattttgaaagataaagccgttaAGCTTCACCAcattc agttttgtTTCATACAATTGATTAAATAactctgaggaagagaatggatactgaatga g" /listShort="S1111, S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2620598..2620617 /Source="Nicolas_upshift_promotors" /id="U2266" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1354 /SigmaFactorBS="gacacattttgaaagataaagccgttaAGCTTCACCAcattc agttttgtTTCATACAATTGATTAAATAactctgaggaagagaatggatactgaatga g" /listShort="S1111, S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2620608..2621002 /Source="Nicolas_S_feature" /locus_tag="new_2996284_2996678" /HighExp="Lbstat, S2, S7, S8, S6, nit, ferm, M0t90, BT, M40t90" /AntisenseName="nrnA" /AntisenseCor="-0.85531073541330804" /AntisenseRegPval="-77.5" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA" /TUshortPSig="1, 0.973" /TUlongSig="SigEF" /TUlongPSig="0.994" /label="S1111" upshifts 2620608 /Source="Nicolas_upshifts" /id="U2266" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1354 /SigmaFactorBS="gacacattttgaaagataaagccgttaAGCTTCACCAcattc agttttgtTTCATACAATTGATTAAATAactctgaggaagagaatggatactgaatga g" /listShort="S1111, S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2620964..2620970 /Source="Nicolas_upshift_promotors" /id="U2267" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.698301698301698" /psig="0.698301698301698" /xcortree=742 /SigmaFactorBS="atgacaagtgcgccttcataTGTTTCAttgtccacctcatca AGGGAATATAAGAAAGAGAGggacggttcaggcgtgccgaccgcaaaaatattttttt c" /listShort="S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2620986..2621005 /Source="Nicolas_upshift_promotors" /id="U2267" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.698301698301698" /psig="0.698301698301698" /xcortree=742 /SigmaFactorBS="atgacaagtgcgccttcataTGTTTCAttgtccacctcatca AGGGAATATAAGAAAGAGAGggacggttcaggcgtgccgaccgcaaaaatattttttt c" /listShort="S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2621004..2621303 /Source="Nicolas_S_feature" /locus_tag="new_2996680_2996979" /HighExp="Lbstat, S8, S7, S6, S2, Etha, nit, ferm, BT, M0t90" /AntisenseName="nrnA" /AntisenseCor="-0.84034645112995598" /AntisenseRegPval="-72.2" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigK, SigA" /TUshortPSig="0.698, 1, 0.973" /TUlongSig="SigEF" /TUlongPSig="0.994" /label="S1112" upshifts 2621004 /Source="Nicolas_upshifts" /id="U2267" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.698301698301698" /psig="0.698301698301698" /xcortree=742 /SigmaFactorBS="atgacaagtgcgccttcataTGTTTCAttgtccacctcatca AGGGAATATAAGAAAGAGAGggacggttcaggcgtgccgaccgcaaaaatattttttt c" /listShort="S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2621192..2621211) /Source="Nicolas_upshift_promotors" /id="U2268" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.515484515484515" /psig="0.995004995004995" /xcortree=2384 /SigmaFactorBS="attttatacaaaaacgggcttggttttgacgttatttttCTT TtccgtcggcagagaATGTGATTTAATGAATAAAAacaataaaggagtatcaaatgaa a" /listShort="nrnA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2621208) /Source="Nicolas_upshifts" /id="U2268" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.515484515484515" /psig="0.995004995004995" /xcortree=2384 /SigmaFactorBS="attttatacaaaaacgggcttggttttgacgttatttttCTT TtccgtcggcagagaATGTGATTTAATGAATAAAAacaataaaggagtatcaaatgaa a" /listShort="nrnA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2621210..2621624) /Source="Nicolas_S_feature" /locus_tag="new_2996886_2997300_c" /HighExp="LBGtran, HiTm, G180, G135, G150, Lbtran, LBGexp, Mt0, Paraq, dia0" /AntisenseName="ytpI" /AntisenseCor="-0.70134306018551296" /AntisenseRegPval="-40.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1113" promotor_-35 complement(2621226..2621229) /Source="Nicolas_upshift_promotors" /id="U2268" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.515484515484515" /psig="0.995004995004995" /xcortree=2384 /SigmaFactorBS="attttatacaaaaacgggcttggttttgacgttatttttCTT TtccgtcggcagagaATGTGATTTAATGAATAAAAacaataaaggagtatcaaatgaa a" /listShort="nrnA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2621304..2621606 /gene="ytpI" /locus_tag="BSU_29260" /old_locus_tag="BSU29260" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390804.1" /db_xref="EnsemblGenomes-Gn:BSU29260" /db_xref="EnsemblGenomes-Tr:CAB14886" /db_xref="GOA:O34922" /db_xref="InterPro:IPR025618" /db_xref="SubtiList:BG13902" /db_xref="UniProtKB/Swiss-Prot:O34922" /translation="MLVLVFLIGLSACFYVYYKVKGVRAKPSLAKEICSAKSSMALGS LVLFYGLNQMILFHSVLTLVIGGIFIVIGAGSAWAGYKAFRHYNPLHAKEAERDHA*" /label="ytpI CDS" gene 2621304..2621606 /gene="ytpI" /locus_tag="BSU_29260" /old_locus_tag="BSU29260" /label="ytpI gene" S_feature 2621607..2623402 /Source="Nicolas_S_feature" /locus_tag="new_2997283_2999078" /HighExp="S8, S6, S7, Lbstat, B36, nit, ferm, T1.0H, C30, S5" /AntisenseName="ytoI" /AntisenseCor="-0.55304378374907204" /AntisenseRegPval="-22.2" /CDS_PredictionProba="0.89152299999999995" /TUshortSig="SigB, SigK, SigA" /TUshortPSig="0.698, 1, 0.973" /TUlongSig="SigEF" /TUlongPSig="0.994" /label="S1114" CDS complement(2621625..2622944) /gene="ytoI" /locus_tag="BSU_29270" /old_locus_tag="BSU29270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 26296725" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390805.1" /db_xref="EnsemblGenomes-Gn:BSU29270" /db_xref="EnsemblGenomes-Tr:CAB14887" /db_xref="GOA:O34921" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR006683" /db_xref="InterPro:IPR010766" /db_xref="InterPro:IPR028979" /db_xref="InterPro:IPR029069" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13897" /db_xref="UniProtKB/Swiss-Prot:O34921" /translation="MATKHEQILTYIDSLPVGEKISVRRIAKEMKVSEGTAYRAIKEA ENKGFVSTIERVGTIRIEQKKKENIEKLTYAEVVNVIDGQVLGGRAGLHKTLNKFVIG AMELDAMMRYTAAGNLLIVGNRINAHRQALEAGAAVLVTGGFNTDDSIVQLADELELP ILSTSYDTFTVAAMINRAIYDQLIKKEIVLVEDILTPADRTVYLSPKDKLEKWYEKNF ETGHGRFPVVDDQMKIHGILTSKDIAGHDRNASIEKVMTKNPVTVIGKTSVASAAQMM VWEGIEVLPVTDGHQKLIGMISRQDVLKALQMIQKQPQVGEKLDDIVSRGFKDEGDDK EDQTVYEYEVTPQMTNQLGTISYGVFTTILTQAANRFLRSKKRGELVIESITIFFLKP VQMESVIEVKPRILEAGRKFGKMEVEVHSQGHIVSKAMLMVQLMERS*" /label="ytoI CDS" gene complement(2621625..2622944) /gene="ytoI" /locus_tag="BSU_29270" /old_locus_tag="BSU29270" /label="ytoI gene" promotor_-10 complement(2622970..2622989) /Source="Nicolas_upshift_promotors" /id="U2269" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.491508491508492" /psig="0.993006993006993" /xcortree=2263 /SigmaFactorBS="ctgtaagaagccggtcgggcttcttttttattttccagcctc ATTGCGtataaatcctttgaAACCTTATAATAAAAACAAGaagactgtccttagaggt g" /listShort="ytoI, S1113, nrnA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2622991) /Source="Nicolas_upshifts" /id="U2269" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.491508491508492" /psig="0.993006993006993" /xcortree=2263 /SigmaFactorBS="ctgtaagaagccggtcgggcttcttttttattttccagcctc ATTGCGtataaatcctttgaAACCTTATAATAAAAACAAGaagactgtccttagaggt g" /listShort="ytoI, S1113, nrnA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2623004..2623009) /Source="Nicolas_upshift_promotors" /id="U2269" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.491508491508492" /psig="0.993006993006993" /xcortree=2263 /SigmaFactorBS="ctgtaagaagccggtcgggcttcttttttattttccagcctc ATTGCGtataaatcctttgaAACCTTATAATAAAAACAAGaagactgtccttagaggt g" /listShort="ytoI, S1113, nrnA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2623120..2624022) /gene="ytnM" /locus_tag="BSU_29280" /old_locus_tag="BSU29280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 23944997; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_390806.1" /db_xref="EnsemblGenomes-Gn:BSU29280" /db_xref="EnsemblGenomes-Tr:CAB14888" /db_xref="GOA:O34430" /db_xref="InterPro:IPR002781" /db_xref="SubtiList:BG13894" /db_xref="UniProtKB/Swiss-Prot:O34430" /translation="MKKLIVFAFIGLLSQLIDGSLGMAYGVTSTSLLLAFGITPAVAS ASVHLAEVVTTAASGVSHIKFGNVDKQTVYQLVIPGSIGAFLGAAFLSQLPGDVAKPY ISLFLLLLGGYVLIRFLFQYKPALEKKHVPLNRKQSIPLGVIAGFADATGGGGWGPVT TPILLSRKGLSPRKVVGTVDTSEFAIAVSATAGFLISLGWEDVNWLWVFSLMAGGIIA APIAAWLVQKFHPQLMGVLVGGFIILVNARTLINEWIANTAVHPLIYTAIGAIWLSAV LFVLSKIGNRNIVKTAVDVHLKEK*" /label="ytnM CDS" gene complement(2623120..2624022) /gene="ytnM" /locus_tag="BSU_29280" /old_locus_tag="BSU29280" /label="ytnM gene" CDS complement(2624041..2625291) /gene="sndA" /locus_tag="BSU_29290" /old_locus_tag="BSU29290" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10588044, 10939241, 11423008, 16109943, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10588044, 10939241, 11423008, 16109943, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="S-alkyl-N-acetyl-metabolite deacetylase" /protein_id="NP_390807.1" /db_xref="EnsemblGenomes-Gn:BSU29290" /db_xref="EnsemblGenomes-Tr:CAB14889" /db_xref="GOA:O34980" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR017439" /db_xref="InterPro:IPR033846" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG12596" /db_xref="UniProtKB/Swiss-Prot:O34980" /translation="MSLDYWRNIEGSYPYQTTGNDILTLKEESNPVNLSTLEKQLIGI RRHLHQYPELSKEEFETTAFIKKCLKEKGIQIRPTALKTGVFADIAGESEGPAIALRA DIDALPIEEKTGLPYASKHKGIMHACGHDFHTAALLGAAFLLKENQDSLKGKIRLLFQ PAEEAGAGATKVIEDGQLDGIDAVIGLHNKPDIAVGTVGLKTGPLMAAVDRFKVEIEG KGAHAALPHNGFDPIIGASQLIVALQTIVSRNVNPLQSAILTVGKINGGSTWNVIPDT VVIEGTVRTFDSEVRNQVKQRFFAVTEQISAAFSLKANVKWHSGPPPLCNDEAITGLV RDAAHKAKLQVIDPAPSTAGEDFAYYLEHIPGSFAFFGTDGDHDWHHPAFTIDETAII KASYFLYESAKRLLDSNEESKISD*" /label="sndA CDS" gene complement(2624041..2625291) /gene="sndA" /locus_tag="BSU_29290" /old_locus_tag="BSU29290" /label="sndA gene" CDS complement(2625309..2626001) /gene="ribR" /locus_tag="BSU_29300" /old_locus_tag="BSU29300" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 15668000, 16109943, 17590224, 23944997, 26494285" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 15668000, 16109943, 17590224, 23944997, 26494285; Product type r: regulator" /codon_start=1 /transl_table=11 /product="FMN-riboswitch-binding activator of rib genes" /protein_id="NP_390808.1" /db_xref="EnsemblGenomes-Gn:BSU29300" /db_xref="EnsemblGenomes-Tr:CAB14890" /db_xref="GOA:P94465" /db_xref="InterPro:IPR015865" /db_xref="InterPro:IPR023465" /db_xref="InterPro:IPR023468" /db_xref="SubtiList:BG11969" /db_xref="UniProtKB/Swiss-Prot:P94465" /translation="MTIIAGTVVKGKQLGRKLGFPTANVDAKIHGLRNGVYGVLATVN HQFHLGVMNIGVKPTVGSNLEKTLEIFLFDFHRDIYGEKIECSILFKIREERRFDSLE SLTKQIKKDISCVAKRFELIGIMAPNKKESLLSHQELNLPDLCFYKKCNNLYGVNRGV YNVIDNWFFEYGITQVAYRRIYILSFLSFLKEDNPKVSSKYIRFGAGGLADKLNRFIS SYVEESEENILG*" /label="ribR CDS" gene complement(2625309..2626001) /gene="ribR" /locus_tag="BSU_29300" /old_locus_tag="BSU29300" /label="ribR gene" CDS complement(2626048..2627376) /gene="cmoJ" /locus_tag="BSU_29310" /old_locus_tag="BSU29310" /EC_number="1.14.-.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 16109943, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 16109943, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="monooxygenase (S-alkyl substrates)" /protein_id="NP_390809.1" /db_xref="EnsemblGenomes-Gn:BSU29310" /db_xref="EnsemblGenomes-Tr:CAB14891" /db_xref="GOA:O34974" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR016215" /db_xref="InterPro:IPR036661" /db_xref="PDB:1TVL" /db_xref="PDB:1YW1" /db_xref="SubtiList:BG13893" /db_xref="UniProtKB/Swiss-Prot:O34974" /translation="MTRADFIQFGAMIHGVGGTTDGWRHPDVDPSASTNIEFYMKKAQ TAEKGLFSFIFIADGLFISEKSIPHFLNRFEPITILSALASVTKNIGLVGTFSTSFTE PFTISRQLMSLDHISGGRAGWNLVTSPQEGAARNHSKSNLPEHTERYEIAQEHLDVVR GLWNSWEHDAFIHNKKTGQFFDQAKLHRLNHKGKYFQVEGPLNIGRSKQGEPVVFQAG SSETGRQFAAKNADAIFTHSNSLEETKAFYADVKSRAADEGRDPSSVRIFPGISPIVA DTEEEAEKKYREFAELIPIENAVTYLARFFDDYDLSVYPLDEPFPDIGDVGKNAFQST TDRIKREAKARNLTLREVAQEMAFPRTLFIGTPERVASLIETWFNAEAADGFIVGSDI PGTLDAFVEKVIPILQERGLYRQDYRGGTLRENLGLGIPQHQSVLHSSHH*" /label="cmoJ CDS" gene complement(2626048..2627376) /gene="cmoJ" /locus_tag="BSU_29310" /old_locus_tag="BSU29310" /label="cmoJ gene" CDS complement(2627373..2627654) /gene="cmoI" /locus_tag="BSU_29320" /old_locus_tag="BSU29320" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 16109943, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 16109943, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="redoxin" /protein_id="NP_390810.1" /db_xref="EnsemblGenomes-Gn:BSU29320" /db_xref="EnsemblGenomes-Tr:CAB14892" /db_xref="GOA:O34639" /db_xref="InterPro:IPR002109" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG13892" /db_xref="UniProtKB/Swiss-Prot:O34639" /translation="MSDVVNIVVWSKKGCSYCEEVKNYLNEKGFPFQNIDVSEKEKLR DILQVKYGVRHVPVVEIGRGNQYQGITEIGIEHLDLALANHAQIKEAKR*" /label="cmoI CDS" gene complement(2627373..2627654) /gene="cmoI" /locus_tag="BSU_29320" /old_locus_tag="BSU29320" /label="cmoI gene" CDS complement(2627669..2628673) /gene="cmoO" /locus_tag="BSU_29330" /old_locus_tag="BSU29330" /EC_number="1.14.-.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9836433, 10939241, 11423008, 16109943, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9836433, 10939241, 11423008, 16109943, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="monooxygenase (S-alkyl substrates)" /protein_id="NP_390811.1" /db_xref="EnsemblGenomes-Gn:BSU29330" /db_xref="EnsemblGenomes-Tr:CAB14893" /db_xref="GOA:O34846" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR019949" /db_xref="InterPro:IPR036661" /db_xref="SubtiList:BG13888" /db_xref="UniProtKB/Swiss-Prot:O34846" /translation="MIRLSILDQSLIGEGETAADTLQHTVKLAQMAEECGYHRFWVAE HHNNDEIAGSAPEVLLGYLAASTRKIRLASGGVMLQHYSSYKVAEQFHLLSALAPGRI DLGVGKAPGGFQLSTDALQAEYKKPVRQFDEKLEELTHFVRDDFPDTHRYAALRPRPQ VDRKPGIFLLGGSTESAISAAKLGISFVFAYFINGEEEVLKEARRAFDAHLPPGSEAE FHLAPAVFAAHTKEEAEKHIVSRESIKVVLKDGRKVNVGSREQAEAYLENVTEPYDII VQKTGIIAGTKEEVAEELTRLSGTYKINDFVIFTPIKNAVEKQLSYQLLSDAVLAAKR *" /label="cmoO CDS" gene complement(2627669..2628673) /gene="cmoO" /locus_tag="BSU_29330" /old_locus_tag="BSU29330" /label="cmoO gene" CDS complement(2628670..2629449) /gene="tcyN" /locus_tag="BSU_29340" /old_locus_tag="BSU29340" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 15262924, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 15262924, 23944997; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sulfur-containing amino-acid ABC transporter (ATP-binding protein)" /protein_id="NP_390812.1" /db_xref="EnsemblGenomes-Gn:BSU29340" /db_xref="EnsemblGenomes-Tr:CAB14894" /db_xref="GOA:O34900" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030679" /db_xref="SubtiList:BG12604" /db_xref="UniProtKB/Swiss-Prot:O34900" /translation="MIEIKNIHKQFGIHHVLKGINLTVRKGEVVTIIGPSGSGKTTFL RCLNLLERPDEGIISIHDKVINCRFPSKKEVHWLRKQTAMVFQQYHLFAHKTVIENVM EGLTIARKMRKQDAYAVAENELRKVGLQDKLNAYPSQLSGGQKQRVGIARALAIHPDV LLFDEPTAALDPELVGEVLEVMLEIVKTGATMIVVTHEMEFARRVSDQVVFMDEGVIV EQGTPEEVFRHTKKDRTRQFLRRVSPEYLFEPKEHIKEPVI*" /label="tcyN CDS" gene complement(2628670..2629449) /gene="tcyN" /locus_tag="BSU_29340" /old_locus_tag="BSU29340" /label="tcyN gene" CDS complement(2629446..2630153) /gene="tcyM" /locus_tag="BSU_29350" /old_locus_tag="BSU29350" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 15262924, 15849754, 16850406, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 15262924, 15849754, 16850406, 23944997; Product type t : transporter" /codon_start=1 /transl_table=11 /product="sulfur-containing amino acid ABC transporter (permease)" /protein_id="NP_390813.1" /db_xref="EnsemblGenomes-Gn:BSU29350" /db_xref="EnsemblGenomes-Tr:CAB14895" /db_xref="GOA:O34931" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG13887" /db_xref="UniProtKB/Swiss-Prot:O34931" /translation="MQFDFPFIVSAMKEMVKTIPLTLMMAVLPIVFGFLVALGNIIVR IFRIKGLVACSRFYVSFFRSTPAILHIMLIYLGIPPVADQVSSFFHLGWSANEIPVSM FVIMALSLTAGAYLTEIIRSGILAMDTGQVEAAYSIGLTYSQTFRRVILPQALKVSIP NFTNLGIGFLHTTSIAAIVAVPEITGTATIVASDNYAFLEAFIGAAIIYWVLTLILES ANGVLERKAARFQGGTL*" /label="tcyM CDS" gene complement(2629446..2630153) /gene="tcyM" /locus_tag="BSU_29350" /old_locus_tag="BSU29350" /label="tcyM gene" CDS complement(2630183..2630902) /gene="tcyL" /locus_tag="BSU_29360" /old_locus_tag="BSU29360" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 15262924, 15849754, 16850406, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 15262924, 15849754, 16850406, 23944997; Product type t : transporter" /codon_start=1 /transl_table=11 /product="sulfur-containing amino acid ABC transporter (permease)" /protein_id="NP_390814.1" /db_xref="EnsemblGenomes-Gn:BSU29360" /db_xref="EnsemblGenomes-Tr:CAB14896" /db_xref="GOA:O34315" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG13886" /db_xref="UniProtKB/Swiss-Prot:O34315" /translation="MEKAFDMNMIGDFVPTLTAYLPVTLYILTLSLLFGFVLGLFLAL PRIYNIPIVNQLAKVYISFFRGTPIMVQLFIVFYGIPALTGLIGIDTSKMDPFYAAVA TYALSNAAAAAEIIRAGVGSVDKGQTEAAYSIGLSGSQAFRRIVLPQALVQAFPNMGN MVISSLKDTSLAFSIGVMDMSGRGQTLITSSNHSLEVYIALSIVYYAVAVLFEWFFRV AEKRIKKNQTRIVTVFDMNIH*" /label="tcyL CDS" gene complement(2630183..2630902) /gene="tcyL" /locus_tag="BSU_29360" /old_locus_tag="BSU29360" /label="tcyL gene" promotor_-35 2630728..2630735 /Source="Nicolas_upshift_promotors" /id="U2270" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig="0.632367632367632" /xcortree=1226 /SigmaFactorBS="caccatgataggcgttcccctgaaaaacgagatatacaCTTT TGCCaattgatttacaatTGGAATATTATAGATGCGGGgcagtgccagaaagagtcct a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2630750..2630769 /Source="Nicolas_upshift_promotors" /id="U2270" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig="0.632367632367632" /xcortree=1226 /SigmaFactorBS="caccatgataggcgttcccctgaaaaacgagatatacaCTTT TGCCaattgatttacaatTGGAATATTATAGATGCGGGgcagtgccagaaagagtcct a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2630750 /Source="Nicolas_upshifts" /id="U2270" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig="0.632367632367632" /xcortree=1226 /SigmaFactorBS="caccatgataggcgttcccctgaaaaacgagatatacaCTTT TGCCaattgatttacaatTGGAATATTATAGATGCGGGgcagtgccagaaagagtcct a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2630924..2631736) /gene="tcyK" /locus_tag="BSU_29370" /old_locus_tag="BSU29370" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 15262924, 22720735, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 15262924, 22720735, 23944997; Product type t : transporter" /codon_start=1 /transl_table=11 /product="sulfur-containing amino acid ABC transporter binding lipoprotein" /protein_id="NP_390815.1" /db_xref="EnsemblGenomes-Gn:BSU29370" /db_xref="EnsemblGenomes-Tr:CAB14897" /db_xref="GOA:O34852" /db_xref="InterPro:IPR001638" /db_xref="PDB:2O1M" /db_xref="SubtiList:BG13885" /db_xref="UniProtKB/Swiss-Prot:O34852" /translation="MKTKTAFMAILFSLITVLSACGAGSQTTGAGQKKVQTITVGTGT QFPNICFIDEKGDLTGYDVELIKELDKRLPHYKFTFKTMEFSNLLVSLGQHKVDIVAH QMEKSKEREKKFLFNKVAYNHFPLKITVLQNNDTIRGIEDLKGKRVITSATSNGALVL KKWNEDNGRPFEIAYEGQGANETANQLKSGRADATISTPFAVDFQNKTSTIKEKTVGN VLSNAKVYFMFNKNEQTLSDDIDKALQEIIDDGTLKRLSLKWLGDDYSKEQY*" /label="tcyK CDS" gene complement(2630924..2631736) /gene="tcyK" /locus_tag="BSU_29370" /old_locus_tag="BSU29370" /label="tcyK gene" CDS complement(2631750..2632559) /gene="tcyJ" /locus_tag="BSU_29380" /old_locus_tag="BSU29380" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 15262924, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 15262924, 23944997; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sulfur containing amino acid ABC transporter binding lipoprotein" /protein_id="NP_390816.1" /db_xref="EnsemblGenomes-Gn:BSU29380" /db_xref="EnsemblGenomes-Tr:CAB14898" /db_xref="GOA:O34406" /db_xref="InterPro:IPR001638" /db_xref="SubtiList:BG13884" /db_xref="UniProtKB/Swiss-Prot:O34406" /translation="MNKRKGLVLLLSVFALLGGGCSQTNNKTDRQAQTVIVGTGTDFP NIAFLNEKGELTGYDIEVMKAIDKELPQYTFEFKTMDFSNLLTSLGNKKIDVIAHNMA KNKEREKRFLYHKVPYNYSPMYITVKEDNHKIHTLKDLHGKTVIVGATSNAADYITKY NKTHGSPIHLKYAGQGSNDTANQIETGRADATIATPFAVDFQNKTHAFRQKTVGDVLL DTEVYFMFNKGSQTLADDTDQAIKKLEKNGTLKKLSRKWLGADYSKSSFEK*" /label="tcyJ CDS" gene complement(2631750..2632559) /gene="tcyJ" /locus_tag="BSU_29380" /old_locus_tag="BSU29380" /label="tcyJ gene" CDS complement(2632573..2633109) /gene="snaA" /locus_tag="BSU_29390" /old_locus_tag="BSU29390" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11390694, 11423008, 16109943, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11390694, 11423008, 16109943, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetyltransferase acting on sulfur compounds" /protein_id="NP_390817.1" /db_xref="EnsemblGenomes-Gn:BSU29390" /db_xref="EnsemblGenomes-Tr:CAB14899" /db_xref="GOA:O34350" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13883" /db_xref="UniProtKB/Swiss-Prot:O34350" /translation="MSDDIFRLATVEDASELLKLVNSAFQPIRQLDIDWPSTRADIQM VSENIEHHSAIVLERDGKLISTITIRFPWESETPPSKYPFVWWFATLPEYKGQGAGSK LLTYVEEKVLRDMLKAPALTLGTSARKHPWLADMYRRRGYEVYFEQEKDGDIGVMMHK VLIPERFNPTLLGAPSWA*" /label="snaA CDS" gene complement(2632573..2633109) /gene="snaA" /locus_tag="BSU_29390" /old_locus_tag="BSU29390" /label="snaA gene" promotor_-35 2633146..2633153 /Source="Nicolas_upshift_promotors" /id="U2271" /multdbtbs="SigA,SigA" /comp="M17" /sig="SigA" /pcomp="0.357642357642358" /psig=1 /xcortree=1744 /SigmaFactorBS="ttttgtcactcctcttcacaaaatatataattcctaTTTGTT TActaagcttttattGTTTATACTATAAAGCATACtctgatctttgactaatcaaaaa a" /listShort="S1115, ytlI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2633164..2633183) /Source="Nicolas_upshift_promotors" /id="U2272" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.673326673326673" /psig=1 /xcortree=1739 /SigmaFactorBS="tcattaaaattactgaagtgaaggtttactttttttGATTAG TCaaagatcagagtaTGCTTTATAGTATAAACAATaaaagcttagtaaacaaatagga a" /listShort="ytmI, tcyJ, tcyK, tcyL, tcyM, tcyN, ytmO, ytnI, ytnJ, rbfK, ytnL, ytnM, ytoI" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2633167..2633186 /Source="Nicolas_upshift_promotors" /id="U2271" /multdbtbs="SigA,SigA" /comp="M17" /sig="SigA" /pcomp="0.357642357642358" /psig=1 /xcortree=1744 /SigmaFactorBS="ttttgtcactcctcttcacaaaatatataattcctaTTTGTT TActaagcttttattGTTTATACTATAAAGCATACtctgatctttgactaatcaaaaa a" /listShort="S1115, ytlI" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2633170..2633261 /Source="Nicolas_S_feature" /locus_tag="new_3008846_3008937" /HighExp="dia5, MG 5, UNK1, MG t5, MG 10, B60, dia0, nit, Diami, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1115" upshifts 2633170 /Source="Nicolas_upshifts" /id="U2271" /multdbtbs="SigA,SigA" /comp="M17" /sig="SigA" /pcomp="0.357642357642358" /psig=1 /xcortree=1744 /SigmaFactorBS="ttttgtcactcctcttcacaaaatatataattcctaTTTGTT TActaagcttttattGTTTATACTATAAAGCATACtctgatctttgactaatcaaaaa a" /listShort="S1115, ytlI" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2633180) /Source="Nicolas_upshifts" /id="U2272" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.673326673326673" /psig=1 /xcortree=1739 /SigmaFactorBS="tcattaaaattactgaagtgaaggtttactttttttGATTAG TCaaagatcagagtaTGCTTTATAGTATAAACAATaaaagcttagtaaacaaatagga a" /listShort="ytmI, tcyJ, tcyK, tcyL, tcyM, tcyN, ytmO, ytnI, ytnJ, rbfK, ytnL, ytnM, ytoI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2633197..2633204) /Source="Nicolas_upshift_promotors" /id="U2272" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.673326673326673" /psig=1 /xcortree=1739 /SigmaFactorBS="tcattaaaattactgaagtgaaggtttactttttttGATTAG TCaaagatcagagtaTGCTTTATAGTATAAACAATaaaagcttagtaaacaaatagga a" /listShort="ytmI, tcyJ, tcyK, tcyL, tcyM, tcyN, ytmO, ytnI, ytnJ, rbfK, ytnL, ytnM, ytoI" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2633262..2634188 /gene="ascR" /locus_tag="BSU_29400" /old_locus_tag="BSU29400" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11390694, 11423008, 15272571, 16109943, 16513748, 22212096, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11390694, 11423008, 15272571, 16109943, 16513748, 22212096, 23944997; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of operon snaA-ytnM degrading cysteine-containing compounds (AscR-N-acetylcysteine)" /protein_id="NP_390818.1" /db_xref="EnsemblGenomes-Gn:BSU29400" /db_xref="EnsemblGenomes-Tr:CAB14900" /db_xref="GOA:O35038" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13877" /db_xref="UniProtKB/Swiss-Prot:O35038" /translation="MELRSIKTFHTIVKFGSFYKAAEILNYSQPTISMRMKQLEQDLG VLLFERGKSLQLTKAGKLFYERTGDLLMQYEALKHNLSDLKEEEAGIINIGVSEPTAS LIFPEILKDFLMDYPKITVNIKVDDANTCSQKLLDGTIDFAVCGEPELILENYYHPFF YDTLNVIVSDQHPLAEKKAVHLSDLAEERFIFTPANCPIRLQIEQHLHRELGNRYKKM ELTSSMSHEYYVRENIGISIFTSTAHSKPFNGTKVIPILNLDITPPIGLLTNQKEVHF DRATKDLIARITKRFQQRSKELEGTSDKTITG*" /label="ascR CDS" gene 2633262..2634188 /gene="ascR" /locus_tag="BSU_29400" /old_locus_tag="BSU29400" /label="ascR gene" S_feature complement(2633664..2634193) /Source="Nicolas_S_feature" /locus_tag="new_3009340_3009869_c" /HighExp="Etha, dia15, dia5, H2O2, M9-stat, M40t90, Sw, Gly, M0t90, Cold" /AntisenseName="ytlI" /AntisenseCor="-7.8012588423369304E-3" /AntisenseRegPval=0 /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1116" downshifts complement(2634238) /Source="Nicolas_upshifts" /id="D1503" /incds=0 /nref=142 /ntot=251 /MaxReadThrough="4.32965" /MaxDrop="5.01142" /score="39.1547987" /energy="-16.5" /TU="U2273" /idTUdmin="U2274" /TUdmin=20 /isTUend="TRUE" /label="downshifts" CDS complement(2634239..2634922) /gene="ytkL" /locus_tag="BSU_29410" /old_locus_tag="BSU29410" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent hydrolase" /protein_id="NP_390819.2" /db_xref="EnsemblGenomes-Gn:BSU29410" /db_xref="EnsemblGenomes-Tr:CAB14901" /db_xref="GOA:Q795U4" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR022877" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG13871" /db_xref="UniProtKB/Swiss-Prot:Q795U4" /translation="MKVTYHGHSVITVETKDHHIIFDPFLTGNSLTDIKPEDVKADVI LLTHGHNDHVGDTEQIAKQNNALVIAPNELAVYLGWKGLNVHPMHIGGSRQFDFGKVK LTQAFHGSAITDEENKTITYTGMPAGILLTVEDKTIFHAGDTALFSDMKLIGELNHID LAFLPIGDNFTMGPEDAKLAAEWLRAKQVVPVHYNTFPVIEQDPEAFADSLPGGVGKV MSVGETIEL*" /label="ytkL CDS" gene complement(2634239..2634922) /gene="ytkL" /locus_tag="BSU_29410" /old_locus_tag="BSU29410" /label="ytkL gene" S_feature complement(2634923..2634984) /Source="Nicolas_S_feature" /locus_tag="new_3010599_3010660_c" /HighExp="dia15, Etha, dia5, Diami, H2O2, M0t90, M40t90, Salt, LBGtran, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1117" CDS complement(2634985..2635752) /gene="ytkK" /locus_tag="BSU_29420" /old_locus_tag="BSU29420" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 3-oxoacyl-acyl-carrier protein reductase" /protein_id="NP_390820.1" /db_xref="EnsemblGenomes-Gn:BSU29420" /db_xref="EnsemblGenomes-Tr:CAB14902" /db_xref="GOA:O34308" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13870" /db_xref="UniProtKB/Swiss-Prot:O34308" /translation="MRHALITAGSKGLGRKVTETLLAKGYSVTVNYRQDEEAVSRLKE ACPDCLDRLQFVKGDVTKKEDLLRIAEAALNRFGRIDFLINNAGPYIFERKKLADYTD DEWYGMLEGNLSAVFHLFKAVIPIMRKQQFGRIITYGFQGAAHAPGWLHRSAFGAAKV GLASLTKTIAIEEAEFGITANMVCPGDIVGDMKEASIEEARMRIGKEKTPIGRSGTGE DIARIIAFLCEENSDLVTGTVIEATGGLNVINKNQTT*" /label="ytkK CDS" gene complement(2634985..2635752) /gene="ytkK" /locus_tag="BSU_29420" /old_locus_tag="BSU29420" /label="ytkK gene" promotor_-10 complement(2635797..2635816) /Source="Nicolas_upshift_promotors" /id="U2273" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.772227772227772" /psig="0.999000999001" /xcortree=1987 /SigmaFactorBS="agctgtctgtacaggcagctttttttgtatgccaaagtgtaa aaaGTGatattgcaagcctttTATAGTAAAGTAGAAGAAGAaacactttattgaaagc g" /listShort="ytkK, S1117, ytkL, S1116" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2635819) /Source="Nicolas_upshifts" /id="U2273" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.772227772227772" /psig="0.999000999001" /xcortree=1987 /SigmaFactorBS="agctgtctgtacaggcagctttttttgtatgccaaagtgtaa aaaGTGatattgcaagcctttTATAGTAAAGTAGAAGAAGAaacactttattgaaagc g" /listShort="ytkK, S1117, ytkL, S1116" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2635832..2635834) /Source="Nicolas_upshift_promotors" /id="U2273" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.772227772227772" /psig="0.999000999001" /xcortree=1987 /SigmaFactorBS="agctgtctgtacaggcagctttttttgtatgccaaagtgtaa aaaGTGatattgcaagcctttTATAGTAAAGTAGAAGAAGAaacactttattgaaagc g" /listShort="ytkK, S1117, ytkL, S1116" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2635879..2636115) /gene="ytzD" /locus_tag="BSU_29430" /old_locus_tag="BSU29430" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11423008" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390821.3" /db_xref="EnsemblGenomes-Gn:BSU29430" /db_xref="EnsemblGenomes-Tr:CAB14903" /db_xref="SubtiList:BG13938" /db_xref="UniProtKB/Swiss-Prot:O34503" /translation="MKKRKLAWQQEFVKISFIKSRHYSQPTSIMMGGRMMKKEPERYI YDEQESQETTRLISEAYQSGYVDMPDQESSSPAE*" /label="ytzD CDS" gene complement(2635879..2636115) /gene="ytzD" /locus_tag="BSU_29430" /old_locus_tag="BSU29430" /label="ytzD gene" downshifts 2635964 /Source="Nicolas_upshifts" /id="D1504" /incds=0 /nref=1 /ntot=12 /MaxReadThrough="0.55049" /MaxDrop="4.17437" /score="-5.88070891" /energy="-8.9" /TU="NA" /idTUdmin="U2271" /TUdmin=1782 /isTUend="FALSE" /label="downshifts" downshifts complement(2635984) /Source="Nicolas_upshifts" /id="D1505" /incds=0 /nref=199 /ntot=288 /MaxReadThrough="5.44889" /MaxDrop="6.29233" /score="21.2322542" /energy="-8.5" /TU="U2274" /idTUdmin="U2274" /TUdmin="-1726" /isTUend="FALSE" /label="downshifts" CDS complement(2636075..2637460) /gene="argH" /locus_tag="BSU_29440" /old_locus_tag="BSU29440" /EC_number="4.3.2.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2989674, 9890879, 11423008" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2989674, 9890879, 11423008; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="argininosuccinate lyase" /protein_id="NP_390822.1" /db_xref="EnsemblGenomes-Gn:BSU29440" /db_xref="EnsemblGenomes-Tr:CAB14904" /db_xref="GOA:O34858" /db_xref="InterPro:IPR000362" /db_xref="InterPro:IPR008948" /db_xref="InterPro:IPR009049" /db_xref="InterPro:IPR020557" /db_xref="InterPro:IPR022761" /db_xref="InterPro:IPR024083" /db_xref="InterPro:IPR029419" /db_xref="SubtiList:BG12571" /db_xref="UniProtKB/Swiss-Prot:O34858" /translation="MKKLWGGRFQKTPEKWVDEFGASISFDQNLVAEDITGSLAHAAM LKKCGILTAEEELKIREGLNTLLQKAEEGALEFSVDYEDIHLNIEKMLIDEIGPLGGK LHTGRSRNDQVATDMHLYLKNHVGHIIELIEAFQSALIEKAEANVETILPGYTHLQRA QPISFAHHLLAYFWMLERDKERFQDSMKRINKSPLGCGALAGTTFPIDRDYSAELLGF DAIYENSLDGVSDRDFILEFLSNSSMLMMHLSRFSEEIILWCSQEFKFIELDDTYATG SSMMPQKKNPDMAELIRGKTGRVYGDMMGLFTIMKGLPLAYNKDLQEDKEGMFDTVKT VEGSLQIFTGMIQTMTVNKDVMKQATKQDFSNATELADYLAKKGMPFREAHEVVGKLV YTCIERGIYLSDMPFGEFQQASTLFEEDIYTVLDPYYAVEKRMSAGGTGFKQVEQALE KAKACVAAGVC*" /label="argH CDS" gene complement(2636075..2637460) /gene="argH" /locus_tag="BSU_29440" /old_locus_tag="BSU29440" /label="argH gene" CDS complement(2637457..2638668) /gene="argG" /locus_tag="BSU_29450" /old_locus_tag="BSU29450" /EC_number="6.3.4.5" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2989674, 11423008, 12963366, 17611193" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2989674, 11423008, 12963366, 17611193; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="argininosuccinate synthase" /protein_id="NP_390823.1" /db_xref="EnsemblGenomes-Gn:BSU29450" /db_xref="EnsemblGenomes-Tr:CAB14905" /db_xref="GOA:O34347" /db_xref="InterPro:IPR001518" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR018223" /db_xref="InterPro:IPR023434" /db_xref="InterPro:IPR024074" /db_xref="SubtiList:BG12570" /db_xref="UniProtKB/Swiss-Prot:O34347" /translation="MSEQKKVVLAYSGGLDTSVAIKWLQEQGYNVIACCLDVGEGKDL AFVQQKALEVGATNSYVIDAKEEFAQDYALISLQAHTMYEGKYPLVSALSRPLIAKKL VEIAEKEDAQAIAHGCTGKGNDQVRFEVSIKSLNPDLEVIAPVREWQWSREEEIEYAA SRGIPIPINLDSPYSIDQNLWGRANECGILEDPWAAPPEGAYDLTAPLEKTPDTPEVI EIAFEQGVPVSIDGVSYSLSELILKLNEMAGAHGVGRIDHVENRLVGIKSREVYECPG AMTLIKAHKELEDLTLVKEVAHFKPIIEQKMSEIIYNGLWFSPLKDALHAFLKETQKH VTGIVRVKLFKGHAIVEGRKSEYSLYDEKLATYTKDDAFDHHAAIGFIELWGLPTKVN SIVKKKEQIKA*" /label="argG CDS" gene complement(2637457..2638668) /gene="argG" /locus_tag="BSU_29450" /old_locus_tag="BSU29450" /label="argG gene" S_feature complement(2638669..2638746) /Source="Nicolas_S_feature" /locus_tag="new_3014345_3014422_c" /HighExp="S1, MG 15, T3.0H, T3.30H, T4.0H, T5.0H, BMM, T2.30H, T-0.40H, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1118" promotor_-10 complement(2638739..2638758) /Source="Nicolas_upshift_promotors" /id="U2274" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=2914 /SigmaFactorBS="ttaggtgaagttttttttataaaagGCTTGAAAaaacgaaac gtactTGTTAAAGTGTATACATACAaaatgtatttttattaaatataatttattttta t" /listShort="S1118, argG, argH, ytzD, ytkK, S1117, ytkL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2638745) /Source="Nicolas_upshifts" /id="U2274" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=2914 /SigmaFactorBS="ttaggtgaagttttttttataaaagGCTTGAAAaaacgaaac gtactTGTTAAAGTGTATACATACAaaatgtatttttattaaatataatttattttta t" /listShort="S1118, argG, argH, ytzD, ytkK, S1117, ytkL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2638773..2638780) /Source="Nicolas_upshift_promotors" /id="U2274" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=2914 /SigmaFactorBS="ttaggtgaagttttttttataaaagGCTTGAAAaaacgaaac gtactTGTTAAAGTGTATACATACAaaatgtatttttattaaatataatttattttta t" /listShort="S1118, argG, argH, ytzD, ytkK, S1117, ytkL" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2638838..2639350) /gene="moaB" /locus_tag="BSU_29460" /old_locus_tag="BSU29460" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15269205, 20054111, 23680484; Product type f: factor" /codon_start=1 /transl_table=11 /product="molybdopterin GTP-binding precursor Z biosynthesis component" /protein_id="NP_390824.1" /db_xref="EnsemblGenomes-Gn:BSU29460" /db_xref="EnsemblGenomes-Tr:CAB14924" /db_xref="GOA:O34457" /db_xref="InterPro:IPR001453" /db_xref="InterPro:IPR008284" /db_xref="InterPro:IPR012245" /db_xref="InterPro:IPR036425" /db_xref="SubtiList:BG12618" /db_xref="UniProtKB/Swiss-Prot:O34457" /translation="MSVQEHKQEAPDIVRCKVITVSDTRTDETDKSGKLMISFLEEAG HHIAAYEIVKDEKDALQRSVLAGCMDEQTDAVLLNGGTGIADRDVTIEAITPLFSKEL PGFGEIFRMLSYTEDIGSAAIMSRATAGVIQHTAVFSTPGSSGAVKLAMNKLIIPELA HVVREIRKDK*" /label="moaB CDS" gene complement(2638838..2639350) /gene="moaB" /locus_tag="BSU_29460" /old_locus_tag="BSU29460" /label="moaB gene" downshifts complement(2638856) /Source="Nicolas_upshifts" /id="D1506" /incds=0 /nref=122 /ntot=221 /MaxReadThrough="1.48097" /MaxDrop="4.78155" /score="25.7910606" /energy="-10.8" /TU="NA" /idTUdmin="U2275" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2639376..2639395) /Source="Nicolas_upshift_promotors" /id="U2275" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.878121878121878" /psig=1 /xcortree=109 /SigmaFactorBS="agcaaaataaatcgcatgaaagcacattCTCTTGAAtgtgct tttttgtTGATGCATGATAGTGACAGAcagaaaacataaaagaggtgggccaatgagc g" /listShort="moaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2639384) /Source="Nicolas_upshifts" /id="U2275" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.878121878121878" /psig=1 /xcortree=109 /SigmaFactorBS="agcaaaataaatcgcatgaaagcacattCTCTTGAAtgtgct tttttgtTGATGCATGATAGTGACAGAcagaaaacataaaagaggtgggccaatgagc g" /listShort="moaB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2639409..2639416) /Source="Nicolas_upshift_promotors" /id="U2275" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.878121878121878" /psig=1 /xcortree=109 /SigmaFactorBS="agcaaaataaatcgcatgaaagcacattCTCTTGAAtgtgct tttttgtTGATGCATGATAGTGACAGAcagaaaacataaaagaggtgggccaatgagc g" /listShort="moaB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2639435..2640622) /gene="ackA" /locus_tag="BSU_29470" /old_locus_tag="BSU29470" /EC_number="2.7.2.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8226682, 9811655, 11244084, 16995897, 19019159, 26098117" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8226682, 9811655, 11244084, 16995897, 19019159, 26098117; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="acetate kinase" /protein_id="NP_390825.1" /db_xref="EnsemblGenomes-Gn:BSU29470" /db_xref="EnsemblGenomes-Tr:CAB14925" /db_xref="GOA:P37877" /db_xref="InterPro:IPR000890" /db_xref="InterPro:IPR004372" /db_xref="InterPro:IPR023865" /db_xref="SubtiList:BG10813" /db_xref="UniProtKB/Swiss-Prot:P37877" /translation="MSKIIAINAGSSSLKFQLFEMPSETVLTKGLVERIGIADSVFTI SVNGEKNTEVTDIPDHAVAVKMLLNKLTEFGIIKDLNEIDGIGHRVVHGGEKFSDSVL LTDETIKEIEDISELAPLHNPANIVGIKAFKEVLPNVPAVAVFDTAFHQTMPEQSYLY SLPYEYYEKFGIRKYGFHGTSHKYVTERAAELLGRPLKDLRLISCHLGNGASIAAVEG GKSIDTSMGFTPLAGVAMGTRSGNIDPALIPYIMEKTGQTADEVLNTLNKKSGLLGIS GFSSDLRDIVEATKEGNERAETALEVFASRIHKYIGSYAARMSGVDAIIFTAGIGENS VEVRERVLRGLEFMGVYWDPALNNVRGEEAFISYPHSPVKVMIIPTDEEVMIARDVVR LAK*" /label="ackA CDS" gene complement(2639435..2640622) /gene="ackA" /locus_tag="BSU_29470" /old_locus_tag="BSU29470" /label="ackA gene" downshifts complement(2639450) /Source="Nicolas_upshifts" /id="D1507" /incds=0 /nref=13 /ntot=117 /MaxReadThrough="5.03131" /MaxDrop="3.1641" /score="19.2403206" /energy="-9.9" /TU="U2276" /idTUdmin="U2277" /TUdmin=242 /isTUend="FALSE" /label="downshifts" S_feature complement(2640623..2640727) /Source="Nicolas_S_feature" /locus_tag="new_3016299_3016403_c" /HighExp="dia0, Lbexp, LBGtran, Oxctl, LPh, M0t45, HPh, Paraq, H2O2, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF" /TUshortPSig="0.999, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1119" promotor_-10 complement(2640712..2640731) /Source="Nicolas_upshift_promotors" /id="U2276" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.918081918081918" /psig="0.999000999001" /xcortree=2694 /SigmaFactorBS="gacttcttattgtaagcgttatcaatacgcaagttgACTTGa aaagccgacatgacAATGTTTAAATGGAAAAGTCagatatttttcggagaagatgttg a" /listShort="S1119, ackA, moaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2640727) /Source="Nicolas_upshifts" /id="U2276" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.918081918081918" /psig="0.999000999001" /xcortree=2694 /SigmaFactorBS="gacttcttattgtaagcgttatcaatacgcaagttgACTTGa aaagccgacatgacAATGTTTAAATGGAAAAGTCagatatttttcggagaagatgttg a" /listShort="S1119, ackA, moaB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2640729..2640858) /Source="Nicolas_S_feature" /locus_tag="new_3016405_3016534_c" /HighExp="S5, S6, S7, S8, S4, dia5, BT, H2O2, dia15, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1120" promotor_-35 complement(2640747..2640751) /Source="Nicolas_upshift_promotors" /id="U2276" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.918081918081918" /psig="0.999000999001" /xcortree=2694 /SigmaFactorBS="gacttcttattgtaagcgttatcaatacgcaagttgACTTGa aaagccgacatgacAATGTTTAAATGGAAAAGTCagatatttttcggagaagatgttg a" /listShort="S1119, ackA, moaB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2640795..2640998) /locus_tag="BSU_29479" /old_locus_tag="BSU29479" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513997.1" /translation="MMNGLKKKSKCFKSSLDSRMRSMPKLLLFMLLKTGLDELNPALK HKIQREKPQIVSVHQYKTYSECV*" /label="hypothetical protein CDS" gene complement(2640795..2640998) /locus_tag="BSU_29479" /old_locus_tag="BSU29479" /label="gene" promotor_-10 complement(2640856..2640867) /Source="Nicolas_upshift_promotors" /id="U2277" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=888 /SigmaFactorBS="tttatttatgcttttgaagaccggacttgaCGAATTGaatcc agctttgaaACACAAAATACAgagggaaaaaccgcaaattgtaagcgttcatcaatac a" /listShort="S1120, S1119, ackA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2640858) /Source="Nicolas_upshifts" /id="U2277" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=888 /SigmaFactorBS="tttatttatgcttttgaagaccggacttgaCGAATTGaatcc agctttgaaACACAAAATACAgagggaaaaaccgcaaattgtaagcgttcatcaatac a" /listShort="S1120, S1119, ackA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2640882..2640888) /Source="Nicolas_upshift_promotors" /id="U2277" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=888 /SigmaFactorBS="tttatttatgcttttgaagaccggacttgaCGAATTGaatcc agctttgaaACACAAAATACAgagggaaaaaccgcaaattgtaagcgttcatcaatac a" /listShort="S1120, S1119, ackA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2640970..2641959) /gene="ytxK" /locus_tag="BSU_29480" /old_locus_tag="BSU29480" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative nucleic acid methyltransferase" /protein_id="NP_390826.1" /db_xref="EnsemblGenomes-Gn:BSU29480" /db_xref="EnsemblGenomes-Tr:CAB14926" /db_xref="GOA:P37876" /db_xref="InterPro:IPR003356" /db_xref="InterPro:IPR016843" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG10812" /db_xref="UniProtKB/Swiss-Prot:P37876" /translation="MQKDHVGAVYELLNEAAIMIKNELQISYIEALAEAGEMYFLEKT DQLKLPADQKTKQLQALLEKAEFGTYEHEWVRKAFQLAVLKGMKDISHPNRQMTPDTI GLFISYLVNKFMADKKELTILDPALGTGNLLFTVLNQLSEKTANSFGIEIDDVLLKIA YAQANLLKKELELFHQDSLEPLFIDPVDTVICDLPVGYYPNDEGAEAFELKADEGHSF AHHLFIEQSVKHTKPGGYLFFMIPNHLFESSQSGKLKQFFKDKVHINALLQLPKSIFK DEAHAKSILVLQKQGENTKAPGQILLANLPSFSNQKAMLDMMAQFDEWFKKEK*" /label="ytxK CDS" gene complement(2640970..2641959) /gene="ytxK" /locus_tag="BSU_29480" /old_locus_tag="BSU29480" /label="ytxK gene" downshifts complement(2640988) /Source="Nicolas_upshifts" /id="D1508" /incds=0 /nref=158 /ntot=243 /MaxReadThrough="3.51469" /MaxDrop="5.25938" /score="-4.33730173" /energy="-13.3" /TU="NA" /idTUdmin="U2279" /TUdmin="-20" /isTUend="TRUE" /label="downshifts" CDS complement(2642020..2642523) /gene="tpx" /locus_tag="BSU_29490" /old_locus_tag="BSU29490" /EC_number="1.11.1.15" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12486061, 18588855, 18588855, 23899494, 25355936, 25852656" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12486061, 18588855, 18588855, 23899494, 25355936, 25852656; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="thiol peroxidase (lipid hydroperoxide reductase)" /protein_id="NP_390827.1" /db_xref="EnsemblGenomes-Gn:BSU29490" /db_xref="EnsemblGenomes-Tr:CAB14927" /db_xref="GOA:P80864" /db_xref="InterPro:IPR002065" /db_xref="InterPro:IPR013740" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR018219" /db_xref="InterPro:IPR036249" /db_xref="PDB:2JSY" /db_xref="PDB:2JSZ" /db_xref="SubtiList:BG13855" /db_xref="UniProtKB/Swiss-Prot:P80864" /translation="MAEITFKGGPVTLVGQEVKVGDQAPDFTVLTNSLEEKSLADMKG KVTIISVIPSIDTGVCDAQTRRFNEEAAKLGDVNVYTISADLPFAQARWCGANGIDKV ETLSDHRDMSFGEAFGVYIKELRLLARSVFVLDENGKVVYAEYVSEATNHPNYEKPIE AAKALVK*" /label="tpx CDS" gene complement(2642020..2642523) /gene="tpx" /locus_tag="BSU_29490" /old_locus_tag="BSU29490" /label="tpx gene" downshifts complement(2642026) /Source="Nicolas_upshifts" /id="D1509" /incds=0 /nref=53 /ntot=241 /MaxReadThrough="6.94509" /MaxDrop="4.3179" /score="9.29337297" /energy="-10.1" /TU="U2279" /idTUdmin="U2280" /TUdmin=548 /isTUend="FALSE" /label="downshifts" promotor_no_box 2642240..2642340 /Source="Nicolas_upshift_promotors" /id="U2278" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.924075924075924" /psig="0.001998001998002" /xcortree=44 /SigmaFactorBS="ccgcaccagcgcgcttgcgcgaatggaaggtctgcactgatt gtgtagacgttgacatctccaagctttgcagcttcttcgttaaaacggcgtgtttgtg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 2642300 /Source="Nicolas_upshifts" /id="U2278" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.924075924075924" /psig="0.001998001998002" /xcortree=44 /SigmaFactorBS="ccgcaccagcgcgcttgcgcgaatggaaggtctgcactgatt gtgtagacgttgacatctccaagctttgcagcttcttcgttaaaacggcgtgtttgtg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2642519 /Source="Nicolas_upshifts" /id="D1510" /incds=0 /nref=86 /ntot=184 /MaxReadThrough="2.23568" /MaxDrop="5.49495" /score="20.1242958" /energy="-12.7" /TU="NA" /idTUdmin="U2278" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2642546..2642565) /Source="Nicolas_upshift_promotors" /id="U2279" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=2364 /SigmaFactorBS="actgcgctggccgcagttaacttttttttggcataaACTTTG CAgtttgcaggaaacTTTACTATGATAGAGACATAcatacaaaagggaggaattataa t" /listShort="tpx, ytxK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2642562) /Source="Nicolas_upshifts" /id="U2279" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=2364 /SigmaFactorBS="actgcgctggccgcagttaacttttttttggcataaACTTTG CAgtttgcaggaaacTTTACTATGATAGAGACATAcatacaaaagggaggaattataa t" /listShort="tpx, ytxK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2642579..2642586) /Source="Nicolas_upshift_promotors" /id="U2279" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=2364 /SigmaFactorBS="actgcgctggccgcagttaacttttttttggcataaACTTTG CAgtttgcaggaaacTTTACTATGATAGAGACATAcatacaaaagggaggaattataa t" /listShort="tpx, ytxK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2642633..2643088) /gene="gerW" /locus_tag="BSU_29500" /old_locus_tag="BSU29500" /experiment="publication(s) with functional evidences, PMID:23921501, 25790435, 27881417" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23921501, 25790435, 27881417; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="germination-associated protein" /protein_id="NP_390828.1" /db_xref="EnsemblGenomes-Gn:BSU29500" /db_xref="EnsemblGenomes-Tr:CAB14928" /db_xref="GOA:O34806" /db_xref="InterPro:IPR014229" /db_xref="SubtiList:BG13849" /db_xref="UniProtKB/Swiss-Prot:O34806" /translation="MADHPIQGLMKTAMENLKEMIDVNTIIGDPVETPDGSVILTVSK VGFGFAAGGSEFGGKPAEKKSEDDETREQKLPFGGGSGGGVSITPIAFLIVGSTGIRM LHLDENTHLIEKILDAAPQTLERIQQMFKKNNKNQSQGQNQNQMNNMNY*" /label="gerW CDS" gene complement(2642633..2643088) /gene="gerW" /locus_tag="BSU_29500" /old_locus_tag="BSU29500" /label="gerW gene" downshifts complement(2642661) /Source="Nicolas_upshifts" /id="D1511" /incds=0 /nref=38 /ntot=91 /MaxReadThrough="3.69502" /MaxDrop="5.65648" /score="26.1939476" /energy="-12.7" /TU="U2280" /idTUdmin="U2280" /TUdmin="-87" /isTUend="FALSE" /label="downshifts" CDS complement(2643102..2643782) /gene="ytfI" /locus_tag="BSU_29510" /old_locus_tag="BSU29510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="conserved sporulation-related protein" /protein_id="NP_390829.1" /db_xref="EnsemblGenomes-Gn:BSU29510" /db_xref="EnsemblGenomes-Tr:CAB14929" /db_xref="InterPro:IPR021338" /db_xref="SubtiList:BG13848" /db_xref="UniProtKB/Swiss-Prot:O34917" /translation="MVYVLTAILILIGIVLLLRMKIHVALEYLHADDNDKLTLKITAL FGLIRIKKTIPAIKVNKEDGTVDIKQKTESKMKKSSGKKKITQNDVQQSINKIEMLLH QVTRLRKISASFLAHLHITKLEWVTVIGIQDAAVTGVLTGAVWGVKGGIAAMLYDHLD FVNKPVYEVIPSFQVPVSKTHFQCIFFFRFGHAMLAAFKFVKYGRELSVLKKNPSARM TSKNDSSV*" /label="ytfI CDS" gene complement(2643102..2643782) /gene="ytfI" /locus_tag="BSU_29510" /old_locus_tag="BSU29510" /label="ytfI gene" upshifts complement(2643194) /Source="Nicolas_upshifts" /id="U2280" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1136 /SigmaFactorBS="gtttccaagacccattttcagTGTATATtcttttttcgcttt GGACATGCTATGcttgcagctttcaaattcgtcaaatacggacgggagctatccgtat t" /listShort="ytfJ" /listLong="tpx, ytxK" /label="upshifts" promotor_-10 complement(2643201..2643212) /Source="Nicolas_upshift_promotors" /id="U2280" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1136 /SigmaFactorBS="gtttccaagacccattttcagTGTATATtcttttttcgcttt GGACATGCTATGcttgcagctttcaaattcgtcaaatacggacgggagctatccgtat t" /listShort="ytfJ" /listLong="tpx, ytxK" /label="promotor_-10" promotor_-35 complement(2643227..2643233) /Source="Nicolas_upshift_promotors" /id="U2280" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1136 /SigmaFactorBS="gtttccaagacccattttcagTGTATATtcttttttcgcttt GGACATGCTATGcttgcagctttcaaattcgtcaaatacggacgggagctatccgtat t" /listShort="ytfJ" /listLong="tpx, ytxK" /label="promotor_-35" downshifts complement(2643520) /Source="Nicolas_upshifts" /id="D1512" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="4.64036" /MaxDrop="2.98792" /score="28.0381876" /energy="-11.8" /TU="U2281" /idTUdmin="U2281" /TUdmin="-308" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2643795..2643813) /Source="Nicolas_upshift_promotors" /id="U2281" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.516483516483517" /psig="0.516483516483517" /xcortree=1030 /SigmaFactorBS="ataccgcaaataaccgataacccggacttccgtccgGGTTTA tttttttaggaattGGCGATAATGCTCCTAGAGgaagtgaagaatatggtgtatgtac t" /listShort="ytfI" /listLong="ytfJ, tpx, ytxK" /label="promotor_-10" upshifts complement(2643809) /Source="Nicolas_upshifts" /id="U2281" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.516483516483517" /psig="0.516483516483517" /xcortree=1030 /SigmaFactorBS="ataccgcaaataaccgataacccggacttccgtccgGGTTTA tttttttaggaattGGCGATAATGCTCCTAGAGgaagtgaagaatatggtgtatgtac t" /listShort="ytfI" /listLong="ytfJ, tpx, ytxK" /label="upshifts" promotor_-35 complement(2643828..2643833) /Source="Nicolas_upshift_promotors" /id="U2281" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.516483516483517" /psig="0.516483516483517" /xcortree=1030 /SigmaFactorBS="ataccgcaaataaccgataacccggacttccgtccgGGTTTA tttttttaggaattGGCGATAATGCTCCTAGAGgaagtgaagaatatggtgtatgtac t" /listShort="ytfI" /listLong="ytfJ, tpx, ytxK" /label="promotor_-35" CDS complement(2643857..2644351) /gene="yteJ" /locus_tag="BSU_29520" /old_locus_tag="BSU29520" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 23155385; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390830.1" /db_xref="EnsemblGenomes-Gn:BSU29520" /db_xref="EnsemblGenomes-Tr:CAB14930" /db_xref="GOA:O34424" /db_xref="InterPro:IPR010432" /db_xref="SubtiList:BG13840" /db_xref="UniProtKB/Swiss-Prot:O34424" /translation="MDATYEELERNDIKGPQEAELLTHAYAGFWVRFWAFLLDWLVIW GLNHLLVSPLFTVLDLPKTSGMFTFSAYSVTTLIVYLAYFALMTKYFRQTLGKMVFGL KVVSVKQDSKLTWSTVIFREVVGRYIDKIWILYIVVAFSPTKQGIHDYIADTTVVHEK LYRK*" /label="yteJ CDS" gene complement(2643857..2644351) /gene="yteJ" /locus_tag="BSU_29520" /old_locus_tag="BSU29520" /label="yteJ gene" downshifts complement(2643872) /Source="Nicolas_upshifts" /id="D1513" /incds=0 /nref=240 /ntot=258 /MaxReadThrough="1.43721" /MaxDrop="6.8315" /score="28.0381876" /energy="-11.8" /TU="NA" /idTUdmin="U2282" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2644364..2645371) /gene="sppA" /locus_tag="BSU_29530" /old_locus_tag="BSU29530" /function="16.1: Circulate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9987136, 10455123, 16484219, 22472423, 23155385, 24228759" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9987136, 10455123, 16484219, 22472423, 23155385, 24228759; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="signal peptide peptidase" /protein_id="NP_390831.1" /db_xref="EnsemblGenomes-Gn:BSU29530" /db_xref="EnsemblGenomes-Tr:CAB14931" /db_xref="GOA:O34525" /db_xref="InterPro:IPR002142" /db_xref="InterPro:IPR004635" /db_xref="InterPro:IPR029045" /db_xref="PDB:3RST" /db_xref="PDB:4KWB" /db_xref="SubtiList:BG13839" /db_xref="UniProtKB/Swiss-Prot:O34525" /translation="MNAKRWIALVIALGIFGVSIIVSISMSFFESVKGAQTDLTSLTD ESQEKTLENGSPSSKIAVLEVSGTIQDNGDSSSLLGADGYNHRTFLKNLERAKDDKTV KGIVLKVNSPGGGVYESAEIHKKLEEIKKETKKPIYVSMGSMAASGGYYISTAADKIF ATPETLTGSLGVIMESVNYSKLADKLGISFETIKSGAHKDIMSPSREMTKEEKNIMQS MVDNSYEGFVDVISKGRGMPKAEVKKIADGRVYDGRQAKKLNLVDELGFYDDTITAMK KDHKDLKNASVISYEESFGLGSLFSMGANKMFKSEIDFLNMREILSQSGSPRMMYLYA K*" /label="sppA CDS" gene complement(2644364..2645371) /gene="sppA" /locus_tag="BSU_29530" /old_locus_tag="BSU29530" /label="sppA gene" promotor_-10 complement(2645395..2645410) /Source="Nicolas_upshift_promotors" /id="U2282" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1672 /SigmaFactorBS="cgtttgccggcagcccgttaagccggagctttctcatgaagT GAAACATTTttcatattgaaTCGTATAATGAGAGAGtttaggaaaaaggaggagaaaa a" /listShort="sppA, yteJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2645412) /Source="Nicolas_upshifts" /id="U2282" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1672 /SigmaFactorBS="cgtttgccggcagcccgttaagccggagctttctcatgaagT GAAACATTTttcatattgaaTCGTATAATGAGAGAGtttaggaaaaaggaggagaaaa a" /listShort="sppA, yteJ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2645414..2645493) /Source="Nicolas_S_feature" /locus_tag="new_3021090_3021169_c" /HighExp="LBGexp, Oxctl, LBGtran, dia0, H2O2, dia15, G180, G150, Paraq, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1121" promotor_-35 complement(2645422..2645431) /Source="Nicolas_upshift_promotors" /id="U2282" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1672 /SigmaFactorBS="cgtttgccggcagcccgttaagccggagctttctcatgaagT GAAACATTTttcatattgaaTCGTATAATGAGAGAGtttaggaaaaaggaggagaaaa a" /listShort="sppA, yteJ" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 2645471..2645490 /Source="Nicolas_upshift_promotors" /id="U2283" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.783216783216783" /psig="0.982017982017982" /xcortree=384 /SigmaFactorBS="aaaatgtttcacttcatgagaaagctccggcttaacgggctg ccggcaaaCGTGGTACACTTATGGCCAAaggtattttatcacaaatactggatggcag a" /listShort="S1122, ppnKB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2645481 /Source="Nicolas_upshifts" /id="U2283" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.783216783216783" /psig="0.982017982017982" /xcortree=384 /SigmaFactorBS="aaaatgtttcacttcatgagaaagctccggcttaacgggctg ccggcaaaCGTGGTACACTTATGGCCAAaggtattttatcacaaatactggatggcag a" /listShort="S1122, ppnKB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2645486..2645505) /Source="Nicolas_upshift_promotors" /id="U2284" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2689 /SigmaFactorBS="ccatttcccctttgctgtcatatttaagTTTTTctgccatcc agtattTGTGATAAAATACCTTTGGCcataagtgtaccacgtttgccggcagcccgtt a" /listShort="S1121, sppA, yteJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2645490..2645556 /Source="Nicolas_S_feature" /locus_tag="new_3021166_3021232" /HighExp="M0t90, Sw, M9-stat, BC, M40t90, T4.0H, T2.30H, S1, T3.30H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.982" /TUlongSig="NA" /TUlongPSig="NA" /label="S1122" upshifts complement(2645493) /Source="Nicolas_upshifts" /id="U2284" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2689 /SigmaFactorBS="ccatttcccctttgctgtcatatttaagTTTTTctgccatcc agtattTGTGATAAAATACCTTTGGCcataagtgtaccacgtttgccggcagcccgtt a" /listShort="S1121, sppA, yteJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2645521..2645525) /Source="Nicolas_upshift_promotors" /id="U2284" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2689 /SigmaFactorBS="ccatttcccctttgctgtcatatttaagTTTTTctgccatcc agtattTGTGATAAAATACCTTTGGCcataagtgtaccacgtttgccggcagcccgtt a" /listShort="S1121, sppA, yteJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2645557..2646360 /gene="ppnKB" /locus_tag="BSU_29540" /old_locus_tag="BSU29540" /EC_number="2.7.1.23" /function="16.7: Manage energy" /function="16.14: Store" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12897004, 16233726, 16511117, 25643072; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="inorganic polyphosphate/ATP-NAD kinase" /protein_id="NP_390832.1" /db_xref="EnsemblGenomes-Gn:BSU29540" /db_xref="EnsemblGenomes-Tr:CAB14932" /db_xref="GOA:O34934" /db_xref="InterPro:IPR002504" /db_xref="InterPro:IPR016064" /db_xref="InterPro:IPR017437" /db_xref="InterPro:IPR017438" /db_xref="SubtiList:BG13837" /db_xref="UniProtKB/Swiss-Prot:O34934" /translation="MTDQRRNVYFFHKQDQETNEQARSLTQLAEEHGFTVVNQHSDAN IIASIGGDGTFLQAVRKTNFRDDCLYVGITKKGKAHLYCDFHSDEREKMVDAMTFEQI EVRKYPLIEVTVDQASPFHCLNEVSIRSSIIKTFVMDVLIDDLHFETFRGDGMIISTP TGSTAYNKSVAGAVVDPLLPCMQVSELASLNNNTYRTLGSPFVLSSDRKLTLRVVQDG NEHPIIGLDNEALSTRNVKTIEIKLSNKKIKTVKLKDNSFWEKVKRTFL*" /label="ppnKB CDS" gene 2645557..2646360 /gene="ppnKB" /locus_tag="BSU_29540" /old_locus_tag="BSU29540" /label="ppnKB gene" downshifts 2646290 /Source="Nicolas_upshifts" /id="D1514" /incds=1 /nref=46 /ntot=222 /MaxReadThrough="5.39036" /MaxDrop="3.90238" /score="19.2746112" /energy="-13.8" /TU="U2283" /idTUdmin="U2283" /TUdmin="-124" /isTUend="FALSE" /label="downshifts" downshifts 2646348 /Source="Nicolas_upshifts" /id="D1515" /incds=0 /nref=6 /ntot=54 /MaxReadThrough="3.14676" /MaxDrop="4.64552" /score="19.2746112" /energy="-13.8" /TU="U2283" /idTUdmin="U2283" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" CDS complement(2646392..2647981) /gene="ytcJ" /locus_tag="BSU_29550" /old_locus_tag="BSU29550" /EC_number="3.5.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19433221, 20386924, 24826896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-substituted formamide deformylase, dihydropyrimidinase or isoaspartyl peptidase" /protein_id="NP_390833.1" /db_xref="EnsemblGenomes-Gn:BSU29550" /db_xref="EnsemblGenomes-Tr:CAB14933" /db_xref="GOA:O34355" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR013108" /db_xref="InterPro:IPR032466" /db_xref="InterPro:IPR033932" /db_xref="SubtiList:BG13835" /db_xref="UniProtKB/Swiss-Prot:O34355" /translation="MKAIWHGGFIYTMLEEGDRTEAVYVEDGVIKGTGSYERLKEKYG SPETEEISLNGAVMFPGFVDSHLHLIGHGEKQLQLDLSALTSKDSILQAAKERERQLP KNDWLIGEGWNENQFETPDYLTKHDLDRLFPDRPVLLKRICRHAIAVNSAALQAAGIS RNTPDPDGGVIVKDANGEPTGLLFDKAQDLILKAVPPVSQHYVDEALTAAIKDCWTKG LTGGHSEDLSYYGDVSVPMKAYEKAAAGGKYPFRCHLLVHHEAVDRWEQLEKLSGPYV EFGAMKIFADGALGGRTALLKEPYQDDPSTNGVQVHDDETLGRLIRKAREKGMEVAVH AIGDLAFEKVLNAIEKHPPKNGRHDRLIHAQVLDNELIERAARMPIALDLQPHFVASD FPWVIDRLGKDRMKTAFAWKTLISKGILCAGGSDAPIEPVDPLLGIQSAVLRKSSHEQ NGPSYNESECLPVYEAIKLYTEGSAGIIYKEKSRGKIAEGYDADFTVLSGDPFAIDPA QLHLLEIKKTVINGQIVYEKS*" /label="ytcJ CDS" gene complement(2646392..2647981) /gene="ytcJ" /locus_tag="BSU_29550" /old_locus_tag="BSU29550" /label="ytcJ gene" downshifts complement(2646401) /Source="Nicolas_upshifts" /id="D1516" /incds=0 /nref=149 /ntot=255 /MaxReadThrough="2.61299" /MaxDrop="5.92403" /score="32.0110789" /energy="-13.8" /TU="NA" /idTUdmin="U2285" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(2648001..2649590) /gene="ytcI" /locus_tag="BSU_29560" /old_locus_tag="BSU29560" /EC_number="6.2.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyl-coenzyme A synthetase" /protein_id="NP_390834.2" /db_xref="EnsemblGenomes-Gn:BSU29560" /db_xref="EnsemblGenomes-Tr:CAB14934" /db_xref="GOA:C0SPB0" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="SubtiList:BG13834" /db_xref="UniProtKB/Swiss-Prot:C0SPB0" /translation="MLKREDLIAPVQYNLVNEMEKFSAAGQKTALLWEDESGKQESWS YEKLMEETNKIGAALADLGFKKGDKLIVMVPRVLEAYAVYLAILKSGMVVIPCSEMLR AKDLEYRIEHAEVKGAIVYSEFIGAFRDVSTADKLITLSIGENDAGWKNLLSIEADGS QFKTADTTRDDMAFLSYTSGTTGQPKGVVHTHGWAFAHLKTSAGAWLDISEKDIVWAT AAPGWQKWVWSPFLAVLGSGATGFVYHGRFKAEKYLELLNRYKINVFCCTPTEYRLMA KVEGLKRFDLSALHSAVSAGEPLNREVIDVFQKHFGIKVRDGYGQTESTLLVGVLKDT PIKPGSMGKPTPGNQVEIINEDGEICKPGEVGDIAVHLSTPALFKEYFKDPERMKTQI RGDYFLTGDRARKDEEGYFWFESRNDDIIISSGYTIGPFEVEDALVKHPEVKECAVVA SPDEIRGSIVKAYVVLQNHEKRSDELVKMLQNHVKTITAPYKYPREIEFVESLPKTAS AKIRRVELRKREEQLKANKKA*" /label="ytcI CDS" gene complement(2648001..2649590) /gene="ytcI" /locus_tag="BSU_29560" /old_locus_tag="BSU29560" /label="ytcI gene" promotor_-10 complement(2649636..2649653) /Source="Nicolas_upshift_promotors" /id="U2285" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.34965034965035" /psig="0.871128871128871" /xcortree=1876 /SigmaFactorBS="aaaggaccagcggcctataaaatctaTGTTTACagaggttgc ttttagGCATATCCTTACGGAAAGagcctgtatttatgtataatgggtggagaaagtg a" /listShort="ytcI, ytcJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2649641) /Source="Nicolas_upshifts" /id="U2285" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.34965034965035" /psig="0.871128871128871" /xcortree=1876 /SigmaFactorBS="aaaggaccagcggcctataaaatctaTGTTTACagaggttgc ttttagGCATATCCTTACGGAAAGagcctgtatttatgtataatgggtggagaaagtg a" /listShort="ytcI, ytcJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2649669..2649675) /Source="Nicolas_upshift_promotors" /id="U2285" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.34965034965035" /psig="0.871128871128871" /xcortree=1876 /SigmaFactorBS="aaaggaccagcggcctataaaatctaTGTTTACagaggttgc ttttagGCATATCCTTACGGAAAGagcctgtatttatgtataatgggtggagaaagtg a" /listShort="ytcI, ytcJ" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2649768) /Source="Nicolas_upshifts" /id="D1517" /incds=0 /nref=242 /ntot=266 /MaxReadThrough="2.32229" /MaxDrop="9.17935" /score="30.5720337" /energy="-13.3" /TU="NA" /idTUdmin="U2287" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2649769..2649978) /gene="sspA" /locus_tag="BSU_29570" /old_locus_tag="BSU29570" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:2456528, 2468649, 3009398, 16707666" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2456528, 2468649, 3009398, 16707666; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein (alpha-type SASP)" /protein_id="NP_390835.1" /db_xref="EnsemblGenomes-Gn:BSU29570" /db_xref="EnsemblGenomes-Tr:CAB14935" /db_xref="GOA:P04831" /db_xref="InterPro:IPR001448" /db_xref="InterPro:IPR018126" /db_xref="SubtiList:BG10786" /db_xref="UniProtKB/Swiss-Prot:P04831" /translation="MANNNSGNSNNLLVPGAAQAIDQMKLEIASEFGVNLGADTTSRA NGSVGGEITKRLVSFAQQNMGGGQF*" /label="sspA CDS" gene complement(2649769..2649978) /gene="sspA" /locus_tag="BSU_29570" /old_locus_tag="BSU29570" /label="sspA gene" promotor_-35 2649974..2649978 /Source="Nicolas_upshift_promotors" /id="U2286" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=706 /SigmaFactorBS="tcgcttgagcagctcctggtactaaaaggttgttgctgttac ctgagttattgttaGCCATgtgtctcaCCTCCTTGTGAGTATagaatgtgtcaaaaca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2649978 /Source="Nicolas_upshifts" /id="U2286" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=706 /SigmaFactorBS="tcgcttgagcagctcctggtactaaaaggttgttgctgttac ctgagttattgttaGCCATgtgtctcaCCTCCTTGTGAGTATagaatgtgtcaaaaca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2649987..2650001 /Source="Nicolas_upshift_promotors" /id="U2286" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=706 /SigmaFactorBS="tcgcttgagcagctcctggtactaaaaggttgttgctgttac ctgagttattgttaGCCATgtgtctcaCCTCCTTGTGAGTATagaatgtgtcaaaaca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2649999..2650010) /Source="Nicolas_upshift_promotors" /id="U2287" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=784 /SigmaFactorBS="tcaattttcagctcctgtatacaattaccaaagtttttcTGA ATGAagccatgtgttttgACACATTCTATActcacaaggaggtgagacacatggctaa c" /listShort="sspA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2650010) /Source="Nicolas_upshifts" /id="U2287" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=784 /SigmaFactorBS="tcaattttcagctcctgtatacaattaccaaagtttttcTGA ATGAagccatgtgttttgACACATTCTATActcacaaggaggtgagacacatggctaa c" /listShort="sspA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2650025..2650031) /Source="Nicolas_upshift_promotors" /id="U2287" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=784 /SigmaFactorBS="tcaattttcagctcctgtatacaattaccaaagtttttcTGA ATGAagccatgtgttttgACACATTCTATActcacaaggaggtgagacacatggctaa c" /listShort="sspA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2650072..2651277) /gene="trmG" /locus_tag="BSU_29580" /old_locus_tag="BSU29580" /EC_number="2.8.1.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 14757766, 16343540, 22773787, 24705700, 28287455" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 14757766, 16343540, 22773787, 24705700, 28287455; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="persulfide ATP pyrophosphatase involved in tRNA modification" /protein_id="NP_390836.2" /db_xref="EnsemblGenomes-Gn:BSU29580" /db_xref="EnsemblGenomes-Tr:CAB14936" /db_xref="GOA:O34595" /db_xref="InterPro:IPR003720" /db_xref="InterPro:IPR004114" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR020536" /db_xref="SubtiList:BG13827" /db_xref="UniProtKB/Swiss-Prot:O34595" /translation="MNYDHILIRFGEISTKGKNRKSFIERLKQNIRLVLKDYPNLKYF SNRDRMTITLNGEDPEALFPHLKQVFGIQSFSLAIKCDSRLDDIKATALKAIKDQYKP GDTFKVATKRAYKQFELDTNQMNAEIGGHILRNTEGLTVDVRNPDIPLRIEIREEATF LTIRDEKGAGGLPVGSAGKAMLMLSGGFDSPVAGFYAMKRGLSVEAVHFFSPPYTSER AKQKVMDLAKCLSRFGGSMTLHIVPFTKTQELIQKQIPENYTMTATRRLMLQIADRIR EKRNGLAIITGESLGQVASQTLESMYAINAVTSTPILRPLIAMDKTEIIEKSREIGTY ETSIQPFEDCCTIFTPPSPKTRPKKEKIEHFESFVDFEPYIQEAVDNIETMTLYSEQE ANDKFAELF*" /label="trmG CDS" gene complement(2650072..2651277) /gene="trmG" /locus_tag="BSU_29580" /old_locus_tag="BSU29580" /label="trmG gene" CDS complement(2651281..2652426) /gene="iscSB" /locus_tag="BSU_29590" /old_locus_tag="BSU29590" /EC_number="2.8.1.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 11443125, 13129955, 14757766, 16388576, 17237162, 14567704, 22773787, 28882201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11443125, 13129955, 14757766, 16388576, 17237162, 14567704, 22773787, 28882201; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cysteine desulfurase" /protein_id="NP_390837.1" /db_xref="EnsemblGenomes-Gn:BSU29590" /db_xref="EnsemblGenomes-Tr:CAB14937" /db_xref="GOA:O34874" /db_xref="InterPro:IPR000192" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR016454" /db_xref="SubtiList:BG12632" /db_xref="UniProtKB/Swiss-Prot:O34874" /translation="MIYLDNSSTTKPYDEVLNVYEQTSSRYFGNPSSLHRYGAETEQL LQAAKNQIKRSLGLKKYDIVFTSGATEANNAALKGAALSKIKTGKHIIATSIEHPSVT ESLEQLKELFGFDITYLSVNEDGFVSIEDLKAAIRPDTVLVSMMHVNNEVGSVQPIEA AGEVLKEHSNILFHVDYVQGIYKVPLAIEKAGIDLCSISGHKFHGLKGTGALIVKEGT RLIPLITGGSQQKGIRAGTEHTAGAVSLAKAINLASADFDTRLDTMTAVKELFMNRLS EIEGVVINTPQMNSAPHIINFSVPGIKAEVLLHMLEEQDIFVSTTSACSAKEHKPSKV LLEMGKGEQIAGSSIRISLNYSQTSDVAEPFMNALRPGIKKLREMMR*" /label="iscSB CDS" gene complement(2651281..2652426) /gene="iscSB" /locus_tag="BSU_29590" /old_locus_tag="BSU29590" /label="iscSB gene" S_feature complement(2652427..2653570) /Source="Nicolas_S_feature" /locus_tag="new_3028103_3029246_c" /HighExp="Diami, dia15, dia5, H2O2, G135, G180, G150, C30, Paraq, LBGstat" /AntisenseName="braB" /AntisenseCor="0.41502288403214899" /AntisenseRegPval="-11.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1123" promotor_-35 2652513..2652520 /Source="Nicolas_upshift_promotors" /id="U2288" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.741258741258741" /psig=1 /xcortree=2628 /SigmaFactorBS="gttaccataacaaaatttaatagaaaattacgaaaaactagt ATTGACTTctaatttttttaCCATATAATAAGATTTGTTCgtttcgtcatattatctg a" /listShort="S1124, braB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2652531..2652620 /Source="Nicolas_S_feature" /locus_tag="new_3028207_3028296" /HighExp="LPh, HPh, BMM, dia0, Heat, G180, Cold, LBGexp, C30, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1124" upshifts 2652531 /Source="Nicolas_upshifts" /id="U2288" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.741258741258741" /psig=1 /xcortree=2628 /SigmaFactorBS="gttaccataacaaaatttaatagaaaattacgaaaaactagt ATTGACTTctaatttttttaCCATATAATAAGATTTGTTCgtttcgtcatattatctg a" /listShort="S1124, braB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2652533..2652552 /Source="Nicolas_upshift_promotors" /id="U2288" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.741258741258741" /psig=1 /xcortree=2628 /SigmaFactorBS="gttaccataacaaaatttaatagaaaattacgaaaaactagt ATTGACTTctaatttttttaCCATATAATAAGATTTGTTCgtttcgtcatattatctg a" /listShort="S1124, braB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2652621..2653958 /gene="braB" /locus_tag="BSU_29600" /old_locus_tag="BSU29600" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11528000, 15849754, 16850406, 26473603" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11528000, 15849754, 16850406, 26473603; Product type t: transporter" /codon_start=1 /transl_table=11 /product="branched-chain amino acid-Na+ symporter" /protein_id="NP_390838.1" /db_xref="EnsemblGenomes-Gn:BSU29600" /db_xref="EnsemblGenomes-Tr:CAB14938" /db_xref="GOA:O34545" /db_xref="InterPro:IPR004685" /db_xref="SubtiList:BG12573" /db_xref="UniProtKB/Swiss-Prot:O34545" /translation="MKHSLPVKDTIIIGFMLFALFFGAGNMIYPPELGQAAGHNVWKA IGGFLLTGVGLPLLGIIAIALTGKDAKGLADKAHPVFGTIFTVVLYLSIGPLFAIPRT GTVSYEIGAVPFLTGVPERLSLLIFTLIFFGVTYYLALNPSKVVDRVGKILTPIKFTI ILIIVLKAIFTPMGGLGAVTEAYKGTPVFKGFLEGYKTMDALASIVFGVVVVNAVKSK GVTQSKALAAACIKAGVIAALGLTFIYVSLAYLGATSTNAIGPVGEGAKILSASSHYL FGSLGNIVLGAAITVACLTTSIGLVTSCGQYFSKLIPALSYKIVVTIVTLFSLIIANF GLAQIIAFSVPILSAIYPLAIVIIVLSFIDKIFKERREVYIACLIGTGLFSILDGIKA AGFSLGSLDVFLNANLPLYSLGIGWVLPGIVGAVIGYVLTLFIGPSKQLNEIS*" /label="braB CDS" gene 2652621..2653958 /gene="braB" /locus_tag="BSU_29600" /old_locus_tag="BSU29600" /label="braB gene" promotor_-10 complement(2653556..2653575) /Source="Nicolas_upshift_promotors" /id="U2289" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.949050949050949" /psig="0.998001998001998" /xcortree=1983 /SigmaFactorBS="gcgagtccgaaattcgcaatgatcaagctgaatAACGTGACa atcgtaacgacaaTTTTATATGATAATGCCGGAataagttttgaaaaatattggccgc a" /listShort="S1123, iscS, thiI, sspA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2653570) /Source="Nicolas_upshifts" /id="U2289" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.949050949050949" /psig="0.998001998001998" /xcortree=1983 /SigmaFactorBS="gcgagtccgaaattcgcaatgatcaagctgaatAACGTGACa atcgtaacgacaaTTTTATATGATAATGCCGGAataagttttgaaaaatattggccgc a" /listShort="S1123, iscS, thiI, sspA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2653590..2653597) /Source="Nicolas_upshift_promotors" /id="U2289" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.949050949050949" /psig="0.998001998001998" /xcortree=1983 /SigmaFactorBS="gcgagtccgaaattcgcaatgatcaagctgaatAACGTGACa atcgtaacgacaaTTTTATATGATAATGCCGGAataagttttgaaaaatattggccgc a" /listShort="S1123, iscS, thiI, sspA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2653934 /Source="Nicolas_upshifts" /id="D1518" /incds=0 /nref=69 /ntot=174 /MaxReadThrough="1.86149" /MaxDrop="6.26921" /score="14.5905051" /energy="-15.2" /TU="U2288" /idTUdmin="U2288" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(2654053..2655741) /gene="ezrA" /locus_tag="BSU_29610" /old_locus_tag="BSU29610" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10449747, 15101985, 15317798, 16549676, 17718511, 17873055, 18363795, 19429628, 21401734, 24218584, 25954268, 28357277" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10449747, 15101985, 15317798, 16549676, 17718511, 17873055, 18363795, 19429628, 21401734, 24218584, 25954268, 28357277; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of FtsZ ring formation" /protein_id="NP_390839.1" /db_xref="EnsemblGenomes-Gn:BSU29610" /db_xref="EnsemblGenomes-Tr:CAB14939" /db_xref="GOA:O34894" /db_xref="InterPro:IPR010379" /db_xref="PDB:4UXV" /db_xref="SubtiList:BG13934" /db_xref="UniProtKB/Swiss-Prot:O34894" /translation="MEFVIGLLIVLLALFAAGYFFRKKIYAEIDRLESWKIEILNRSI VEEMSKIKHLKMTGQTEEFFEKWREEWDEIVTAHMPKVEELLYDAEENADKYRFKKAN QVLVHIDDLLTAAESSIEKILREISDLVTSEEKSREEIEQVRERYSKSRKNLLAYSHL YGELYDSLEKDLDEIWSGIKQFEEETEGGNYITARKVLLEQDRNLERLQSYIDDVPKL LADCKQTVPGQIAKLKDGYGEMKEKGYKLEHIQLDKELENLSNQLKRAEHVLMTELDI DEASAILQLIDENIQSVYQQLEGEVEAGQSVLSKMPELIIAYDKLKEEKEHTKAETEL VKESYRLTAGELGKQQAFEKRLDEIGKLLSSVKDKLDAEHVAYSLLVEEVASIEKQIE EVKKEHAEYRENLQALRKEELQARETLSNLKKTISETARLLKTSNIPGIPSHIQEMLE NAHHHIQETVNQLNELPLNMEEAGAHLKQAEDIVNRASRESEELVEQVILIEKIIQFG NRFRSQNHILSEQLKEAERRFYAFDYDDSYEIAAAAVEKAAPGAVEKIKADISA*" /label="ezrA CDS" gene complement(2654053..2655741) /gene="ezrA" /locus_tag="BSU_29610" /old_locus_tag="BSU29610" /label="ezrA gene" downshifts complement(2654054) /Source="Nicolas_upshifts" /id="D1519" /incds=0 /nref=224 /ntot=257 /MaxReadThrough="3.34218" /MaxDrop="5.3305" /score="9.25784495" /energy="-8.6" /TU="U2290" /idTUdmin="U2290" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" S_feature complement(2655742..2655847) /Source="Nicolas_S_feature" /locus_tag="new_3031418_3031523_c" /HighExp="C90, Lbtran, BMM, LBGtran, MG 150, S1, Lbexp, dia0, LBGexp, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.975" /TUlongSig="NA" /TUlongPSig="NA" /label="S1125" promotor_-35 2655824..2655832 /Source="Nicolas_upshift_promotors" /id="U2291" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2258 /SigmaFactorBS="ttattcagaaagatttcaggatatgtattgagaaaaaCTGTC GTTTtcattgttatTATGATACCATGTAACAAACattttttgaccagaaatcaaaaac t" /listShort="S1126, hisJ, S1129, S1130, S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2655835..2655854) /Source="Nicolas_upshift_promotors" /id="U2290" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig=1 /xcortree=2331 /SigmaFactorBS="cctgccgattttgcacaaaaagtttttgatttctgGTCaaaa aatgtttgttaCATGGTATCATAATAACAATgaaaacgacagtttttctcaatacata t" /listShort="S1125, ezrA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2655843..2655862 /Source="Nicolas_upshift_promotors" /id="U2291" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2258 /SigmaFactorBS="ttattcagaaagatttcaggatatgtattgagaaaaaCTGTC GTTTtcattgttatTATGATACCATGTAACAAACattttttgaccagaaatcaaaaac t" /listShort="S1126, hisJ, S1129, S1130, S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2655847) /Source="Nicolas_upshifts" /id="U2290" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig=1 /xcortree=2331 /SigmaFactorBS="cctgccgattttgcacaaaaagtttttgatttctgGTCaaaa aatgtttgttaCATGGTATCATAATAACAATgaaaacgacagtttttctcaatacata t" /listShort="S1125, ezrA" /GFF_Attribute="listLong" /label="upshifts" upshifts 2655847 /Source="Nicolas_upshifts" /id="U2291" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2258 /SigmaFactorBS="ttattcagaaagatttcaggatatgtattgagaaaaaCTGTC GTTTtcattgttatTATGATACCATGTAACAAACattttttgaccagaaatcaaaaac t" /listShort="S1126, hisJ, S1129, S1130, S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="upshifts" S_feature 2655848..2655937 /Source="Nicolas_S_feature" /locus_tag="new_3031524_3031613" /HighExp="HiOs, C90, dia5, T-5.40H, S1, T-3.40H, GM-0.1, GM 15, T3.0H, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1126" S_feature complement(2655849..2656408) /Source="Nicolas_S_feature" /locus_tag="new_3031525_3032084_c" /HighExp="Etha, Salt, Cold, G135, Lbstat, G180, G150, H2O2, Heat, Paraq" /AntisenseName="hisJ" /AntisenseCor="0.37018688255337001" /AntisenseRegPval="-9.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.975" /TUlongSig="NA" /TUlongPSig="NA" /label="S1127" promotor_-35 complement(2655870..2655872) /Source="Nicolas_upshift_promotors" /id="U2290" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig=1 /xcortree=2331 /SigmaFactorBS="cctgccgattttgcacaaaaagtttttgatttctgGTCaaaa aatgtttgttaCATGGTATCATAATAACAATgaaaacgacagtttttctcaatacata t" /listShort="S1125, ezrA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2655938..2656744 /gene="hisK" /locus_tag="BSU_29620" /old_locus_tag="BSU29620" /EC_number="3.1.3.15" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10322033" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10322033; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="histidinol phosphate phosphatase" /protein_id="NP_390840.1" /db_xref="EnsemblGenomes-Gn:BSU29620" /db_xref="EnsemblGenomes-Tr:CAB14940" /db_xref="GOA:O34411" /db_xref="InterPro:IPR004013" /db_xref="InterPro:IPR010140" /db_xref="InterPro:IPR016195" /db_xref="SubtiList:BG13931" /db_xref="UniProtKB/Swiss-Prot:O34411" /translation="MQKRDGHIHTPFCPHGSNDTLRQYAEEALKKGFESITFTEHAPL PPSFTDPTPLKDSAMAQASLERYIHEISGLKKEYRGQLSIRTGLEVDYIAEFEDEITL FLDTYGPYLDDSILSVHFLRTDSSYLCLDYDEHTFKELISACGSIEAVYEQYYRSIYS SIVASLGVYKPKRVGHITLVQKFIKLFPYSMSEHIRGLVSLCLNAIEENGMELDFNTS GLRKTYAGGIYIEDWMLNEAKQKKIPLVFGSDAHQAGDVGYAYEAFLERC*" /label="hisK CDS" gene 2655938..2656744 /gene="hisK" /locus_tag="BSU_29620" /old_locus_tag="BSU29620" /label="hisK gene" promotor_-10 complement(2656412..2656431) /Source="Nicolas_upshift_promotors" /id="U2292" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.92007992007992" /psig="0.975024975024975" /xcortree=92 /SigmaFactorBS="aatttttggacgagtgtgatgtgaccgactcttttTGGCTTA TaaacgccgagaGATGCTACAATGGAAGAATAgatactccggtaatattgttcatata c" /listShort="S1127, S1125, ezrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2656425) /Source="Nicolas_upshifts" /id="U2292" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.92007992007992" /psig="0.975024975024975" /xcortree=92 /SigmaFactorBS="aatttttggacgagtgtgatgtgaccgactcttttTGGCTTA TaaacgccgagaGATGCTACAATGGAAGAATAgatactccggtaatattgttcatata c" /listShort="S1127, S1125, ezrA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2656443..2656450) /Source="Nicolas_upshift_promotors" /id="U2292" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.92007992007992" /psig="0.975024975024975" /xcortree=92 /SigmaFactorBS="aatttttggacgagtgtgatgtgaccgactcttttTGGCTTA TaaacgccgagaGATGCTACAATGGAAGAATAgatactccggtaatattgttcatata c" /listShort="S1127, S1125, ezrA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2656694..2656740) /Source="Nicolas_S_feature" /locus_tag="new_3032370_3032416_c" /HighExp="M9-stat, T5.0H, LoTm, T4.0H, S2, BC, T3.30H, S4, T3.0H, B60" /AntisenseName="hisJ" /AntisenseCor="-0.46006853678527698" /AntisenseRegPval="-14.8" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1128" downshifts complement(2656716) /Source="Nicolas_upshifts" /id="D1520" /incds=0 /nref=51 /ntot=97 /MaxReadThrough="1.55523" /MaxDrop="6.84653" /score="-4.34170655" /energy="-10.5" /TU="NA" /idTUdmin="U2296" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2656741..2657364) /gene="refZ" /locus_tag="BSU_29630" /old_locus_tag="BSU29630" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11988534, 22730127, 26360512" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11988534, 22730127, 26360512; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of FtsZ defining the chromosome regioncaptured in the forespore" /protein_id="NP_390841.1" /db_xref="EnsemblGenomes-Gn:BSU29630" /db_xref="EnsemblGenomes-Tr:CAB14941" /db_xref="GOA:O34970" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR023772" /db_xref="SubtiList:BG13927" /db_xref="UniProtKB/Swiss-Prot:O34970" /translation="MKVSTKDKIIESAVMLFNQKGFSGTSVREIAKSADVNVAHISYY FKGKGGLMEHLVSEFYEGYSKTLETAASNISTQSTQEQLLQLVFDILSYQHNHRQLTR FVYREVTIDSTLIREIMSTYLMKEKYIFQLIIEEGEKQREYLTLPLPHFILQLKSLLM MPYLQPQYISEVLYMQPHEPYFYKMYFEEIKIWIRSVFRTGDVALTN*" /label="refZ CDS" gene complement(2656741..2657364) /gene="refZ" /locus_tag="BSU_29630" /old_locus_tag="BSU29630" /label="refZ gene" S_feature 2656745..2657087 /Source="Nicolas_S_feature" /locus_tag="new_3032421_3032763" /HighExp="C90, HiOs, Sw, dia5, GM-0.1, S1, MG 5, UNK1, MG 60, MG t5" /AntisenseName="yttP" /AntisenseCor="-0.79169109805002003" /AntisenseRegPval="-58.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1129" promotor_-35 2657065..2657072 /Source="Nicolas_upshift_promotors" /id="U2293" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig="0.999000999001" /xcortree=2053 /SigmaFactorBS="ggagtcaattgtgacttcccggtagacaaaacgagtTAATTG ACgatgattatgctgaTAGGATAAAATATCGAAAACcaattgaagaagctgttcctgc g" /listShort="S1130, S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2657087..2657106 /Source="Nicolas_upshift_promotors" /id="U2293" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig="0.999000999001" /xcortree=2053 /SigmaFactorBS="ggagtcaattgtgacttcccggtagacaaaacgagtTAATTG ACgatgattatgctgaTAGGATAAAATATCGAAAACcaattgaagaagctgttcctgc g" /listShort="S1130, S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2657089..2657232 /Source="Nicolas_S_feature" /locus_tag="new_3032765_3032908" /HighExp="Diami, dia15, dia5, H2O2, C90, Paraq, Salt, Etha, Oxctl, Sw" /AntisenseName="yttP" /AntisenseCor="-0.81457903975257295" /AntisenseRegPval="-64.400000000000006" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1130" upshifts 2657089 /Source="Nicolas_upshifts" /id="U2293" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig="0.999000999001" /xcortree=2053 /SigmaFactorBS="ggagtcaattgtgacttcccggtagacaaaacgagtTAATTG ACgatgattatgctgaTAGGATAAAATATCGAAAACcaattgaagaagctgttcctgc g" /listShort="S1130, S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2657204..2657208 /Source="Nicolas_upshift_promotors" /id="U2294" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.322677322677323" /psig="0.982017982017982" /xcortree=2757 /SigmaFactorBS="ctgtagccttcgtaaaactctgaaactaagTGTTCcatcaag cctcctttGCCTTTAAAATAGTAGGAGAtgtgcgcaacatttacatcagctgactttg c" /listShort="S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2657224..2657243 /Source="Nicolas_upshift_promotors" /id="U2294" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.322677322677323" /psig="0.982017982017982" /xcortree=2757 /SigmaFactorBS="ctgtagccttcgtaaaactctgaaactaagTGTTCcatcaag cctcctttGCCTTTAAAATAGTAGGAGAtgtgcgcaacatttacatcagctgactttg c" /listShort="S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2657234..2657364 /Source="Nicolas_S_feature" /locus_tag="new_3032910_3033040" /HighExp="Diami, dia15, dia5, H2O2, Paraq, C90, HPh, LBGexp, Oxctl, Sw" /AntisenseName="yttP" /AntisenseCor="-0.82273476313537297" /AntisenseRegPval="-66.7" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.982, 0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1131" upshifts 2657234 /Source="Nicolas_upshifts" /id="U2294" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.322677322677323" /psig="0.982017982017982" /xcortree=2757 /SigmaFactorBS="ctgtagccttcgtaaaactctgaaactaagTGTTCcatcaag cctcctttGCCTTTAAAATAGTAGGAGAtgtgcgcaacatttacatcagctgactttg c" /listShort="S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="upshifts" S_feature 2657366..2657490 /Source="Nicolas_S_feature" /locus_tag="new_3033042_3033166" /HighExp="Diami, dia5, dia15, H2O2, C90, BC, HiOs, Paraq, Sw, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="0.598, 0.982, 0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1132" upshifts 2657366 /Source="Nicolas_upshifts" /id="U2295" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.582417582417582" /psig="0.598401598401598" /xcortree=570 /SigmaFactorBS="ttttggttaaaaagcatgacagcagattcaataattttgtct ttggtgcttactttcatacggctcactccttcctCTTGATACTATTCAAGCAGAaagc c" /listShort="S1132, ytsP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2657380..2657398) /Source="Nicolas_upshift_promotors" /id="U2296" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=448 /SigmaFactorBS="aaagttccggcttttctgccggcatttgtcgataagttcttA CAGGAACAgcggctttctGCTTGAATAGTATCAAGAGgaaggagtgagccgtatgaaa g" /listShort="yttP" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature 2657382..2657401 /Source="Nicolas_upshift_promotors" /id="U2295" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.582417582417582" /psig="0.598401598401598" /xcortree=570 /SigmaFactorBS="ttttggttaaaaagcatgacagcagattcaataattttgtct ttggtgcttactttcatacggctcactccttcctCTTGATACTATTCAAGCAGAaagc c" /listShort="S1132, ytsP" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2657398) /Source="Nicolas_upshifts" /id="U2296" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=448 /SigmaFactorBS="aaagttccggcttttctgccggcatttgtcgataagttcttA CAGGAACAgcggctttctGCTTGAATAGTATCAAGAGgaaggagtgagccgtatgaaa g" /listShort="yttP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2657409..2657417) /Source="Nicolas_upshift_promotors" /id="U2296" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=448 /SigmaFactorBS="aaagttccggcttttctgccggcatttgtcgataagttcttA CAGGAACAgcggctttctGCTTGAATAGTATCAAGAGgaaggagtgagccgtatgaaa g" /listShort="yttP" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2657491..2657982 /gene="msrC" /locus_tag="BSU_29640" /old_locus_tag="BSU29640" /EC_number="1.8.4.14" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17535911, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="free methionine-(R)-sulfoxide reductase" /protein_id="NP_390842.2" /db_xref="EnsemblGenomes-Gn:BSU29640" /db_xref="EnsemblGenomes-Tr:CAB14942" /db_xref="InterPro:IPR000614" /db_xref="InterPro:IPR003018" /db_xref="InterPro:IPR029016" /db_xref="SubtiList:BG13923" /db_xref="UniProtKB/Swiss-Prot:O34553" /translation="MFHVEKQSGDKEKDYQLLLKQLEAMTEDETDQIANYANASALLY HSLPEVNWAGFYFAKEEDGQLVLGPFQGLPACVRIPFGRGVCGTAYANGKVERIEDVN AFPGHIACDAASQSEIVLPIRVDGKIVGVLDIDSPVKNRFDEIDEKYLTQFAETLEKA LAQ*" /label="msrC CDS" gene 2657491..2657982 /gene="msrC" /locus_tag="BSU_29640" /old_locus_tag="BSU29640" /label="msrC gene" downshifts 2657961 /Source="Nicolas_upshifts" /id="D1521" /incds=0 /nref=72 /ntot=213 /MaxReadThrough="3.66093" /MaxDrop="6.50628" /score="34.0123402" /energy="-11.9" /TU="U2291,U2293,U2294" /idTUdmin="U2295" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2658020..2659759) /gene="dgcP" /locus_tag="BSU_29650" /old_locus_tag="BSU29650" /EC_number="2.7.7.65" /function="16.12: Sense" /function="16.3: Control" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:23893111" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23893111; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="diguanylate cyclase" /protein_id="NP_390843.1" /db_xref="EnsemblGenomes-Gn:BSU29650" /db_xref="EnsemblGenomes-Tr:CAB14943" /db_xref="InterPro:IPR000160" /db_xref="InterPro:IPR029016" /db_xref="InterPro:IPR029787" /db_xref="SubtiList:BG13918" /db_xref="UniProtKB/Swiss-Prot:O34325" /translation="MVEQTKDQLSAFHYHMLDFLLTKSEKVTFTDSFIWLTSAIQTYF STLCVSLTPSPSDFVTKLADGEARFSASKINASCYLIEDGSGRRFHLACRQDEEIPEG LPDVVASFLNQSMKQERLYNKTIYQKKIYKMTELFHSLLDQTDVLKQLLESLTSTFSL FEFSLFISHDQDQCLGIPAKELYMEGEKSDSFALKVYLSGDILRKNESVAYIPIKGQQ GTYGVLKAEGTGDSFLTDACLDEMSLLANAAGKAFENAQLYEQSKASIANLELINETS RRLNQRLTLTDTMNDLAVRMAESFQAEEVGFFHIDHFENLTLLPGSTAFFKEAKPSDF YNELKEKLYEGEKGVFIGNGQSVFGKAGYGSLMAAPMIQNDRLLGFAVLLKQELYAFT FEMYKLFQALIHHATLAVTNSMLRDRLEHLVKTDQLTELYSRAYLDEKIQYSMKIHQK GVFILVDIDNFKNVNDTYGHQTGDEILIQVASVIKSNIRKHDVGARWGGEELAIYLPN VPVAVGKRITERLVYAVRKNTKPEVTISCGISCWTTETKKSLKELVHEADEALYSAKR SGKNRLMIHDSIK*" /label="dgcP CDS" gene complement(2658020..2659759) /gene="dgcP" /locus_tag="BSU_29650" /old_locus_tag="BSU29650" /label="dgcP gene" downshifts complement(2658038) /Source="Nicolas_upshifts" /id="D1522" /incds=0 /nref=23 /ntot=178 /MaxReadThrough="3.68958" /MaxDrop="4.52201" /score="-0.637788006" /energy="-11.9" /TU="U2298" /idTUdmin="U2298" /TUdmin="-45" /isTUend="FALSE" /label="downshifts" promotor_-35 2659233..2659240 /Source="Nicolas_upshift_promotors" /id="U2297" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2821 /SigmaFactorBS="ttttccccttccatatacagctcttttgcaggaatcCCTAAA CAttggtcttgatcgTGCGATATAAATAAAGAAAactcaaaaagagaaaatgtgcttg t" /listShort="S1133, S1135, rpsD" /listLong="S1137" /label="promotor_-35" promotor_-10 2659254..2659272 /Source="Nicolas_upshift_promotors" /id="U2297" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2821 /SigmaFactorBS="ttttccccttccatatacagctcttttgcaggaatcCCTAAA CAttggtcttgatcgTGCGATATAAATAAAGAAAactcaaaaagagaaaatgtgcttg t" /listShort="S1133, S1135, rpsD" /listLong="S1137" /label="promotor_-10" upshifts 2659257 /Source="Nicolas_upshifts" /id="U2297" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2821 /SigmaFactorBS="ttttccccttccatatacagctcttttgcaggaatcCCTAAA CAttggtcttgatcgTGCGATATAAATAAAGAAAactcaaaaagagaaaatgtgcttg t" /listShort="S1133, S1135, rpsD" /listLong="S1137" /label="upshifts" S_feature 2659259..2659854 /Source="Nicolas_S_feature" /locus_tag="new_3034935_3035530" /HighExp="Cold, LBGstat, C30, Lbstat, GM 25, GM 10, GM 120, GM-0.1, GM 5, GM-0.2" /AntisenseName="ytrP" /AntisenseCor="-0.113221814489707" /AntisenseRegPval="-1.2" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1133" misc_feature complement(2659789..2659808) /Source="Nicolas_upshift_promotors" /id="U2298" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.897102897102897" /psig="0.999000999001" /xcortree=428 /SigmaFactorBS="aatttatttgttttgaagtcaaccattcctccattattgctt caccgttTATGATATAATAAACAAAAAttagtggtaaacttttaggtgataaaaacat g" /listShort="ytrP" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2659797) /Source="Nicolas_upshifts" /id="U2298" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.897102897102897" /psig="0.999000999001" /xcortree=428 /SigmaFactorBS="aatttatttgttttgaagtcaaccattcctccattattgctt caccgttTATGATATAATAAACAAAAAttagtggtaaacttttaggtgataaaaacat g" /listShort="ytrP" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2659799..2660632) /Source="Nicolas_S_feature" /locus_tag="new_3035475_3036308_c" /HighExp="Etha, S7, Gly, S8, M9-stat, Sw, G135, S6, BC, C30" /AntisenseName="rpsD" /AntisenseCor="-0.48019282175486899" /AntisenseRegPval="-16.2" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.965" /TUlongSig="NA" /TUlongPSig="NA" /label="S1134" promotor_-35 2659835..2659842 /Source="Nicolas_upshift_promotors" /id="U2299" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.837162837162837" /psig=1 /xcortree=2658 /SigmaFactorBS="ttattatatcataaacggtgaagcaataatggaggaatgGTT GACTTcaaaacaaataaaTTATATAATGACCTTTGTGTgaaatattgcagcctttttg t" /listShort="S1135, rpsD, S1137" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2659856..2660053 /Source="Nicolas_S_feature" /locus_tag="new_3035532_3035729" /HighExp="UNK1, Cold, HPh, C30, aero, LPhT, MG 25, Oxctl, Heat, GM 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.139124" /TUshortSig="SigA, SigD" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1135" promotor_-10 2659856..2659875 /Source="Nicolas_upshift_promotors" /id="U2299" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.837162837162837" /psig=1 /xcortree=2658 /SigmaFactorBS="ttattatatcataaacggtgaagcaataatggaggaatgGTT GACTTcaaaacaaataaaTTATATAATGACCTTTGTGTgaaatattgcagcctttttg t" /listShort="S1135, rpsD, S1137" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2659856 /Source="Nicolas_upshifts" /id="U2299" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.837162837162837" /psig=1 /xcortree=2658 /SigmaFactorBS="ttattatatcataaacggtgaagcaataatggaggaatgGTT GACTTcaaaacaaataaaTTATATAATGACCTTTGTGTgaaatattgcagcctttttg t" /listShort="S1135, rpsD, S1137" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 2659913..2660045 /gene="ldsD" /locus_tag="BSU_misc_RNA_93" /product="ribosomal protein S4 leader mRNA sequence" /experiment="publication(s) with functional evidences, PMID:23611891" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23611891" /label="ldsD RNA" gene 2659913..2660045 /gene="ldsD" /locus_tag="BSU_misc_RNA_93" /label="ldsD gene" CDS 2660054..2660656 /gene="rpsD" /locus_tag="BSU_29660" /old_locus_tag="BSU29660" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1400226, 1699930, 1906866, 12682299, 23611891" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1400226, 1699930, 1906866, 12682299, 23611891; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S4 (BS4)" /protein_id="NP_390844.1" /db_xref="EnsemblGenomes-Gn:BSU29660" /db_xref="EnsemblGenomes-Tr:CAB14944" /db_xref="GOA:P21466" /db_xref="InterPro:IPR001912" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR005709" /db_xref="InterPro:IPR018079" /db_xref="InterPro:IPR022801" /db_xref="InterPro:IPR036986" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10372" /db_xref="UniProtKB/Swiss-Prot:P21466" /translation="MARYTGPSWKLSRRLGISLSGTGKELEKRPYAPGPHGPGQRKKL SEYGLQLQEKQKLRHMYGVNERQFRTLFDKAGKLAGKHGENFMILLDSRLDNVVYKLG LARTRRQARQLVNHGHILVDGSRVDIPSYLVKPGQTIGVREKSRNLSIIKESVEVNNF VPEYLTFDAEKLEGTFTRLPERSELAPEINEALIVEFYSR*" /label="rpsD CDS" gene 2660054..2660656 /gene="rpsD" /locus_tag="BSU_29660" /old_locus_tag="BSU29660" /label="rpsD gene" downshifts 2660579 /Source="Nicolas_upshifts" /id="D1523" /incds=1 /nref=1 /ntot=106 /MaxReadThrough="8.1141" /MaxDrop="2.9392" /score="31.6842" /energy="-13.6" /TU="U2297,U2299" /idTUdmin="U2297" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" S_feature complement(2660634..2660853) /Source="Nicolas_S_feature" /locus_tag="new_3036310_3036529_c" /HighExp="S5, Etha, S8, S6, S7, S4, BT, S3, M9-stat, B36" /AntisenseName="rpsD" /AntisenseCor="-0.59018291599064199" /AntisenseRegPval="-25.9" /CDS_PredictionProba="0.99997899999999995" /TUshortSig="SigB" /TUshortPSig="0.965" /TUlongSig="NA" /TUlongPSig="NA" /label="S1136" downshifts 2660642 /Source="Nicolas_upshifts" /id="D1524" /incds=0 /nref=135 /ntot=252 /MaxReadThrough="5.6866" /MaxDrop="6.10502" /score="31.6842" /energy="-13.6" /TU="U2299" /idTUdmin="U2297" /TUdmin=19 /isTUend="TRUE" /label="downshifts" downshifts complement(2660677) /Source="Nicolas_upshifts" /id="D1525" /incds=0 /nref=1 /ntot=23 /MaxReadThrough="4.84346" /MaxDrop="3.28594" /score="-4.07107651" /energy="-10.8" /TU="U2300" /idTUdmin="U2301" /TUdmin=264 /isTUend="FALSE" /label="downshifts" downshifts 2660689 /Source="Nicolas_upshifts" /id="D1526" /incds=0 /nref=1 /ntot=28 /MaxReadThrough="5.7799" /MaxDrop="4.26349" /score="31.6842" /energy="-13.6" /TU="U2299" /idTUdmin="U2297" /TUdmin=66 /isTUend="FALSE" /label="downshifts" S_feature 2660734..2660907 /Source="Nicolas_S_feature" /locus_tag="new_3036410_3036583" /HighExp="LBGtran, LoTm, C30, Cold, LBGexp, B60, dia15, B36, H2O2, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigD" /TUlongPSig=1 /label="S1137" promotor_-10 complement(2660849..2660867) /Source="Nicolas_upshift_promotors" /id="U2300" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.965034965034965" /psig="0.965034965034965" /xcortree=732 /SigmaFactorBS="agatcctttgccactgaaggcaaaggatcttttTGTTTACcg cataggaatgaaAGGAAAAGAGTATATTAGAtagggcaaacacgaccaatcaccacct t" /listShort="S1136, S1134, ytrP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2660861) /Source="Nicolas_upshifts" /id="U2300" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.965034965034965" /psig="0.965034965034965" /xcortree=732 /SigmaFactorBS="agatcctttgccactgaaggcaaaggatcttttTGTTTACcg cataggaatgaaAGGAAAAGAGTATATTAGAtagggcaaacacgaccaatcaccacct t" /listShort="S1136, S1134, ytrP" /GFF_Attribute="listLong" /label="upshifts" downshifts 2660865 /Source="Nicolas_upshifts" /id="D1527" /incds=0 /nref=7 /ntot=151 /MaxReadThrough="1.39547" /MaxDrop="6.12149" /score="26.4940291" /energy="-16.4" /TU="NA" /idTUdmin="U2299" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 complement(2660882..2660888) /Source="Nicolas_upshift_promotors" /id="U2300" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.965034965034965" /psig="0.965034965034965" /xcortree=732 /SigmaFactorBS="agatcctttgccactgaaggcaaaggatcttttTGTTTACcg cataggaatgaaAGGAAAAGAGTATATTAGAtagggcaaacacgaccaatcaccacct t" /listShort="S1136, S1134, ytrP" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2660927..2662195) /gene="tyrS" /locus_tag="BSU_29670" /old_locus_tag="BSU29670" /EC_number="6.1.1.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12547201, 15879350, 1735721, 9098057" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12547201, 15879350, 1735721, 9098057; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tyrosyl-tRNA synthetase" /protein_id="NP_390845.1" /db_xref="EnsemblGenomes-Gn:BSU29670" /db_xref="EnsemblGenomes-Tr:CAB14945" /db_xref="GOA:P22326" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR002305" /db_xref="InterPro:IPR002307" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR024088" /db_xref="InterPro:IPR024107" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG10371" /db_xref="UniProtKB/Swiss-Prot:P22326" /translation="MTNLLEDLSFRGLIQQMTDEEGLNKQLNEEKIRLYSGFDPTADS LHIGHLLPILTLRRFQLAGHHPIALVGGATGLIGDPSGKKAERTLNTADIVSEWSQKI KNQLSRFLDFEAAENPAVIANNFDWIGKMNVIDFLRDVGKNFGINYMLAKDTVSSRIE SGISYTEFSYMILQSYDFLNLYRDKNCKLQIGGSDQWGNITAGLELIRKSEEEGAKAF GLTIPLVTKADGTKFGKTEGGAIWLDKEKTSPYEFYQFWINTDDRDVVKYLKYFTFLS KEEIEAYAEKTETAPEKREAQKRLAEEVTSLVHGREALEQAINISQALFSGNIKELSA QDVKVGFKDVPSMEVDSTQELSLVDVLVQSKLSPSKRQAREDIQNGAVYINGERQTEI NYTLSGEDRIENQFTVLRRGKKKYFLVTYK*" /label="tyrS CDS" gene complement(2660927..2662195) /gene="tyrS" /locus_tag="BSU_29670" /old_locus_tag="BSU29670" /label="tyrS gene" downshifts complement(2660953) /Source="Nicolas_upshifts" /id="D1528" /incds=0 /nref=110 /ntot=357 /MaxReadThrough="2.2673" /MaxDrop="6.847" /score="22.5238672" /energy="-16.4" /TU="NA" /idTUdmin="U2301" /TUdmin="-12" /isTUend="TRUE" /label="downshifts" misc_RNA complement(2662219..2662492) /gene="tboY" /locus_tag="BSU_misc_RNA_83" /product="T-Box riboswitch specific of tyrosine tRNA ligase" /experiment="publication(s) with functional evidences, PMID:8045882, 10943892, 1317842, 9098041, 12165569, 12547201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045882, 10943892, 1317842, 9098041, 12165569, 12547201; Product type n : RNA" /function="16.3: Control" /label="tboY RNA" gene complement(2662219..2662492) /gene="tboY" /locus_tag="BSU_misc_RNA_83" /label="tboY gene" S_feature complement(2662240..2662383) /Source="Nicolas_S_feature" /locus_tag="new_3037916_3038059_c" /HighExp="B60, Sw, B36, BC, M9-stat, T1.30H, S4, T4.0H, T2.30H, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.40126600000000001" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1138" downshifts complement(2662283) /Source="Nicolas_upshifts" /id="D1529" /incds=0 /nref=58 /ntot=127 /MaxReadThrough="6.75235" /MaxDrop="6.49727" /score="45.7279775" /energy="-17.7" /TU="U2301,U2303" /idTUdmin="U2301" /TUdmin="-1342" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2662490..2662509) /Source="Nicolas_upshift_promotors" /id="U2301" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.587412587412587" /psig="0.998001998001998" /xcortree=599 /SigmaFactorBS="gagatctgtcaacaatggaggattaaaaggcggCGTTGACAc aggattttattTATGTTAAAAATGATATAGCttcatatgaaaaggtaaagattgagac a" /listShort="ytzK, S1138, tyrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2662502) /Source="Nicolas_upshifts" /id="U2301" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.587412587412587" /psig="0.998001998001998" /xcortree=599 /SigmaFactorBS="gagatctgtcaacaatggaggattaaaaggcggCGTTGACAc aggattttattTATGTTAAAAATGATATAGCttcatatgaaaaggtaaagattgagac a" /listShort="ytzK, S1138, tyrS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2662522..2662529) /Source="Nicolas_upshift_promotors" /id="U2301" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.587412587412587" /psig="0.998001998001998" /xcortree=599 /SigmaFactorBS="gagatctgtcaacaatggaggattaaaaggcggCGTTGACAc aggattttattTATGTTAAAAATGATATAGCttcatatgaaaaggtaaagattgagac a" /listShort="ytzK, S1138, tyrS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2662537..2664255) /gene="acsA" /locus_tag="BSU_29680" /old_locus_tag="BSU29680" /EC_number="6.2.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7934817, 10986270, 11255012, 16855235, 18487328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7934817, 10986270, 11255012, 16855235, 18487328; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-CoA synthetase" /protein_id="NP_390846.1" /db_xref="EnsemblGenomes-Gn:BSU29680" /db_xref="EnsemblGenomes-Tr:CAB14946" /db_xref="GOA:P39062" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="SubtiList:BG10370" /db_xref="UniProtKB/Swiss-Prot:P39062" /translation="MNLKALPAIEGDHNLKNYEETYRHFDWAEAEKHFSWHETGKLNA AYEAIDRHAESFRKNKVALYYKDAKRDEKYTFKEMKEESNRAGNVLRRYGNVEKGDRV FIFMPRSPELYFIMLGAIKIGAIAGPLFEAFMEGAVKDRLENSEAKVVVTTPELLERI PVDKLPHLQHVFVVGGEAESGTNIINYDEAAKQESTRLDIEWMDKKDGFLLHYTSGST GTPKGVLHVHEAMIQQYQTGKWVLDLKEEDIYWCTADPGWVTGTVYGIFAPWLNGATN VIVGGRFSPESWYGTIEQLGVNVWYSAPTAFRMLMGAGDEMAAKYDLTSLRHVLSVGE PLNPEVIRWGHKVFNKRIHDTWWMTETGSQLICNYPCMDIKPGSMGKPIPGVEAAIVD NQGNELPPYRMGNLAIKKGWPSMMHTIWNNPEKYESYFMPGGWYVSGDSAYMDEEGYF WFQGRVDDVIMTSGERVGPFEVESKLVEHPAIAEAGVIGKPDPVRGEIIKAFIALREG FEPSDKLKEEIRLFVKQGLAAHAAPREIEFKDKLPKTRSGKIMRRVLKAWELNLPAGD LSTMED*" /label="acsA CDS" gene complement(2662537..2664255) /gene="acsA" /locus_tag="BSU_29680" /old_locus_tag="BSU29680" /label="acsA gene" promotor_-35 2664269..2664276 /Source="Nicolas_upshift_promotors" /id="U2302" /multdbtbs="-" /comp="M18" /sig="SigA" /pcomp="0.355644355644356" /psig="0.63936063936064" /xcortree=379 /SigmaFactorBS="gtaacgctttcaagttcatgcccaaacatcccCCTTTGCTga agttgtcacaatTATTATAGTATATATTCATAttcttctcaatttttaaaatataaac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2664283..2664302) /Source="Nicolas_upshift_promotors" /id="U2303" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.48051948051948" /psig="0.999000999001" /xcortree=357 /SigmaFactorBS="aataccaaattataaagcgttttcaacatggtttatatttta aaAATTGAGaagaatatgaataTATACTATAATAATTGTGACaacttcagcaaagggg g" /listShort="acsA, ytzK, S1138, tyrS" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2664291..2664310 /Source="Nicolas_upshift_promotors" /id="U2302" /multdbtbs="-" /comp="M18" /sig="SigA" /pcomp="0.355644355644356" /psig="0.63936063936064" /xcortree=379 /SigmaFactorBS="gtaacgctttcaagttcatgcccaaacatcccCCTTTGCTga agttgtcacaatTATTATAGTATATATTCATAttcttctcaatttttaaaatataaac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2664297 /Source="Nicolas_upshifts" /id="U2302" /multdbtbs="-" /comp="M18" /sig="SigA" /pcomp="0.355644355644356" /psig="0.63936063936064" /xcortree=379 /SigmaFactorBS="gtaacgctttcaagttcatgcccaaacatcccCCTTTGCTga agttgtcacaatTATTATAGTATATATTCATAttcttctcaatttttaaaatataaac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2664306) /Source="Nicolas_upshifts" /id="U2303" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.48051948051948" /psig="0.999000999001" /xcortree=357 /SigmaFactorBS="aataccaaattataaagcgttttcaacatggtttatatttta aaAATTGAGaagaatatgaataTATACTATAATAATTGTGACaacttcagcaaagggg g" /listShort="acsA, ytzK, S1138, tyrS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2664316..2664322) /Source="Nicolas_upshift_promotors" /id="U2303" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.48051948051948" /psig="0.999000999001" /xcortree=357 /SigmaFactorBS="aataccaaattataaagcgttttcaacatggtttatatttta aaAATTGAGaagaatatgaataTATACTATAATAATTGTGACaacttcagcaaagggg g" /listShort="acsA, ytzK, S1138, tyrS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2664339..2664346 /Source="Nicolas_upshift_promotors" /id="U2304" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.615384615384615" /psig="0.993006993006993" /xcortree=496 /SigmaFactorBS="tattcatattcttctcaatttttaaaatataaaccaTGTTGA AAacgctttataattTGGTATTCTTAAAGAAGGCAtgtatttttgataagaattgatg g" /listShort="acuA, acuB, acuC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2664360..2664379 /Source="Nicolas_upshift_promotors" /id="U2304" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.615384615384615" /psig="0.993006993006993" /xcortree=496 /SigmaFactorBS="tattcatattcttctcaatttttaaaatataaaccaTGTTGA AAacgctttataattTGGTATTCTTAAAGAAGGCAtgtatttttgataagaattgatg g" /listShort="acuA, acuB, acuC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2664363 /Source="Nicolas_upshifts" /id="U2304" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.615384615384615" /psig="0.993006993006993" /xcortree=496 /SigmaFactorBS="tattcatattcttctcaatttttaaaatataaaccaTGTTGA AAacgctttataattTGGTATTCTTAAAGAAGGCAtgtatttttgataagaattgatg g" /listShort="acuA, acuB, acuC" /GFF_Attribute="listLong" /label="upshifts" CDS 2664416..2665048 /gene="acuA" /locus_tag="BSU_29690" /old_locus_tag="BSU29690" /EC_number="2.3.1.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7934817, 10368162, 10809684, 11274109, 16855235, 18487328, 19136592, 24957627" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7934817, 10368162, 10809684, 11274109, 16855235, 18487328, 19136592, 24957627; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein acetyltransferase (acetylates AcsA)" /protein_id="NP_390847.1" /db_xref="EnsemblGenomes-Gn:BSU29690" /db_xref="EnsemblGenomes-Tr:CAB14947" /db_xref="GOA:P39065" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR024699" /db_xref="SubtiList:BG10369" /db_xref="UniProtKB/Swiss-Prot:P39065" /translation="MEHHKTYHSANIKTATGSLLIEGPVSPEDLAGYEFHKDLTAFRP PREQHEALVDIAGLPEGRIIIARDGRTIVGYVTYLYPDPLERWSEGNMEDLIELGAIE VAPDYRGCAVGKTLLTVSMMDEQMENYIVMTTEYYWHWDLKGMKKDVWEYRKIMEKMM NAGGLVWFATDEPEISSHPANCLMARIGKNVSQESIEQFDRLRFYHRYMY*" /label="acuA CDS" gene 2664416..2665048 /gene="acuA" /locus_tag="BSU_29690" /old_locus_tag="BSU29690" /label="acuA gene" promotor_-35 2664621..2664629 /Source="Nicolas_upshift_promotors" /id="U2305" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.931068931068931" /psig="0.931068931068931" /xcortree=1263 /SigmaFactorBS="tcccgaagggcgcattattattgccagagacgGCCGAACCAt tgtcggctatgtCACGTATTTATATCCTGACCcgctcgaaagatggtctgaaggaaat a" /listShort="acuB, acuC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2664643..2664662 /Source="Nicolas_upshift_promotors" /id="U2305" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.931068931068931" /psig="0.931068931068931" /xcortree=1263 /SigmaFactorBS="tcccgaagggcgcattattattgccagagacgGCCGAACCAt tgtcggctatgtCACGTATTTATATCCTGACCcgctcgaaagatggtctgaaggaaat a" /listShort="acuB, acuC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2664649 /Source="Nicolas_upshifts" /id="U2305" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.931068931068931" /psig="0.931068931068931" /xcortree=1263 /SigmaFactorBS="tcccgaagggcgcattattattgccagagacgGCCGAACCAt tgtcggctatgtCACGTATTTATATCCTGACCcgctcgaaagatggtctgaaggaaat a" /listShort="acuB, acuC" /GFF_Attribute="listLong" /label="upshifts" CDS 2665075..2665719 /gene="acuB" /locus_tag="BSU_29700" /old_locus_tag="BSU29700" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7934817, 10368162, 10809684, 11274109, 16855235, 18487328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7934817, 10368162, 10809684, 11274109, 16855235, 18487328; Product type f : factor" /codon_start=1 /transl_table=11 /product="component of the acetyl-coenzyme A synthetase regulation pathway" /protein_id="NP_390848.1" /db_xref="EnsemblGenomes-Gn:BSU29700" /db_xref="EnsemblGenomes-Tr:CAB14948" /db_xref="GOA:P39066" /db_xref="InterPro:IPR000644" /db_xref="SubtiList:BG10368" /db_xref="UniProtKB/Swiss-Prot:P39066" /translation="MIVEQIMKRDVITLTKTDTLETAICKLKEFHIRHLPVVDEERHV IGMITDRDMKQASPSIFEENKRSLFLTRSVDSIMKKDVVCAHPLDFVEEISAVFYEHG IGCLPVVHHQKLIGILTKTDLLRTFVKLTGADQPGSQIEIKVNDITKSLAEISSLCQD LQVKILSVLVYPHDDPGVKVLVFRVKTMNPLPFLQALQRNGHHVVWPSEQRDLL*" /label="acuB CDS" gene 2665075..2665719 /gene="acuB" /locus_tag="BSU_29700" /old_locus_tag="BSU29700" /label="acuB gene" CDS 2665716..2666879 /gene="acuC" /locus_tag="BSU_29710" /old_locus_tag="BSU29710" /EC_number="3.5.1.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7934817, 10368162, 10809684, 11274109, 16855235, 18487328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7934817, 10368162, 10809684, 11274109, 16855235, 18487328; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="protein deacetylase (regulates AcsA activity)" /protein_id="NP_390849.1" /db_xref="EnsemblGenomes-Gn:BSU29710" /db_xref="EnsemblGenomes-Tr:CAB14949" /db_xref="GOA:P39067" /db_xref="InterPro:IPR000286" /db_xref="InterPro:IPR003085" /db_xref="InterPro:IPR023696" /db_xref="InterPro:IPR023801" /db_xref="InterPro:IPR037138" /db_xref="SubtiList:BG10367" /db_xref="UniProtKB/Swiss-Prot:P39067" /translation="MRDSVFIYSPSYQTYMFHQEHPFNQQRVLLTYDLLKTINAFDDG DIVTPRLASEEELSLVHTDDYIQAVKLAGAGKLPAEEGESYGLGTEDTPVFAGMHEAA SLLVGGTLTAADWVMSGQALHAANLGGGLHHGFRGRASGFCIYNDSAVAIQYIQKKYS ARVLYIDTDAHHGDGVQFTFYDNPDVCTLSIHETGRYLFPGTGQIQEKGSGKGYGYSF NIPLDAFTEDDSFLEAYRTAASEVAAYFEPDVIISQNGADAHYYDPLTHLSATINIYE EIPRLAHTLAHQYCGGKWIAVGGGGYDIWRVVPRAWARIWLEMKGIDPGHEIPPEWIV KWQKQCPVALPSSWSDPADLYPPIPRKPEITEKNAQTVSKALYAIRSEQQRTK*" /label="acuC CDS" gene 2665716..2666879 /gene="acuC" /locus_tag="BSU_29710" /old_locus_tag="BSU29710" /label="acuC gene" downshifts 2666870 /Source="Nicolas_upshifts" /id="D1530" /incds=0 /nref=98 /ntot=231 /MaxReadThrough="0.530530000000001" /MaxDrop="6.5095" /score="10.9528437" /energy="-9.1" /TU="NA" /idTUdmin="U2304" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2666890..2667618) /gene="motS" /locus_tag="BSU_29720" /old_locus_tag="BSU29720" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9260952, 15306009, 16095621, 16547058, 23049994, 28378843, 29109979" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9260952, 15306009, 16095621, 16547058, 23049994, 28378843, 29109979; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sodium channel stator-force generator peptidoglycan binding subunit of flagellar rotation" /protein_id="NP_390850.1" /db_xref="EnsemblGenomes-Gn:BSU29720" /db_xref="EnsemblGenomes-Tr:CAB14950" /db_xref="GOA:P39064" /db_xref="InterPro:IPR006665" /db_xref="InterPro:IPR025713" /db_xref="InterPro:IPR036737" /db_xref="SubtiList:BG10366" /db_xref="UniProtKB/Swiss-Prot:P39064" /translation="MKLRRERFERRNGSGKNSQSSSSWMVTFTDLITLILVFFILLFS MSQIDLQKFKAAVDSIQKEGNGLQPDQTSIEKKNTSPSDTKKQEDQQDQLLKKVNTYI KDNHLKAQMTAKRDERGVVLVLQEAVLFDTGEAKVLKNAETLLHQIAVLLQTIPNDIQ VEGHTDSRNISTYRYPSNWELSAARASGVIQYFTSKEKLPSKRFIAVGYADTKPVKDN KTNEHMKENRRVEIVIKKSKTTSS*" /label="motS CDS" gene complement(2666890..2667618) /gene="motS" /locus_tag="BSU_29720" /old_locus_tag="BSU29720" /label="motS gene" downshifts complement(2666926) /Source="Nicolas_upshifts" /id="D1531" /incds=0 /nref=37 /ntot=149 /MaxReadThrough="1.3853" /MaxDrop="3.98206" /score="4.77211813" /energy="-6.9" /TU="NA" /idTUdmin="U2307" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2667608..2668426) /gene="motP" /locus_tag="BSU_29730" /old_locus_tag="BSU29730" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9260952, 15306009, 16095621, 16547058, 23049994, 28378843, 29109979" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9260952, 15306009, 16095621, 16547058, 23049994, 28378843, 29109979; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sodium channel stator-force generator subunit offlagellar rotation" /protein_id="NP_390851.1" /db_xref="EnsemblGenomes-Gn:BSU29730" /db_xref="EnsemblGenomes-Tr:CAB14951" /db_xref="GOA:P39063" /db_xref="InterPro:IPR000540" /db_xref="InterPro:IPR002898" /db_xref="SubtiList:BG10365" /db_xref="UniProtKB/Swiss-Prot:P39063" /translation="MKRFDYLTPVGFVLGTIIIVIGIISGSGVSGFRSFLDLTSFFIV TGGLCAAVFISFPPSELKKAPSVLKQAFIRQEDNVKDLVKTFVSLSDHARKHGLLSLD DQAREIKDPFLKKGLLLAIDGWDEETIRLVMDSEIAAMEERHRKGRRVFEKAGEFAPA WGMIGTLVGLVLMLKNLNDPHMLGPNMAIALLTTLYGSLLANMVFNPIAAKLEEKTES EIFIKQVMVEGIIGVQSGKNPRNLESQLVVFSSREEWQKQPKQVKTKKGSVHEA*" /label="motP CDS" gene complement(2667608..2668426) /gene="motP" /locus_tag="BSU_29730" /old_locus_tag="BSU29730" /label="motP gene" CDS complement(2668489..2669493) /gene="ccpA" /locus_tag="BSU_29740" /old_locus_tag="BSU29740" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11931564, 14665673, 16316990, 17085448, 17827291, 18757537, 19202299, 22001508, 22512862, 23123903, 25157083, 26712933, 28617843" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11931564, 14665673, 16316990, 17085448, 17827291, 18757537, 19202299, 22001508, 22512862, 23123903, 25157083, 26712933, 28617843; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of catabolite repression (Lacl family)" /protein_id="NP_390852.1" /db_xref="EnsemblGenomes-Gn:BSU29740" /db_xref="EnsemblGenomes-Tr:CAB14952" /db_xref="GOA:P25144" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR006377" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="PDB:1ZVV" /db_xref="PDB:2FEP" /db_xref="PDB:3OQM" /db_xref="PDB:3OQN" /db_xref="PDB:3OQO" /db_xref="SubtiList:BG10376" /db_xref="UniProtKB/Swiss-Prot:P25144" /translation="MSNITIYDVAREANVSMATVSRVVNGNPNVKPTTRKKVLEAIER LGYRPNAVARGLASKKTTTVGVIIPDISSIFYSELARGIEDIATMYKYNIILSNSDQN MEKELHLLNTMLGKQVDGIVFMGGNITDEHVAEFKRSPVPIVLAASVEEQEETPSVAI DYEQAIYDAVKLLVDKGHTDIAFVSGPMAEPINRSKKLQGYKRALEEANLPFNEQFVA EGDYTYDSGLEALQHLMSLDKKPTAILSATDEMALGIIHAAQDQGLSIPEDLDIIGFD NTRLSLMVRPQLSTVVQPTYDIGAVAMRLLTKLMNKEPVEEHIVELPHRIELRKSTKS *" /label="ccpA CDS" gene complement(2668489..2669493) /gene="ccpA" /locus_tag="BSU_29740" /old_locus_tag="BSU29740" /label="ccpA gene" downshifts complement(2668506) /Source="Nicolas_upshifts" /id="D1532" /incds=0 /nref=62 /ntot=239 /MaxReadThrough="4.60553" /MaxDrop="4.6531" /score="5.3377823" /energy="-13.2" /TU="U2307,U2308,U2309" /idTUdmin="U2306" /TUdmin=3 /isTUend="TRUE" /label="downshifts" misc_feature complement(2669528..2669547) /Source="Nicolas_upshift_promotors" /id="U2306" /multdbtbs="-" /comp="M5" /sig="SigA" /pcomp="0.366633366633367" /psig="0.577422577422577" /xcortree=1443 /SigmaFactorBS="cgcttacaaatcataaacgacataaattcggacattatgaca tttctctacataaaGTGTTTATGCTATAGATAAGgataagtgtatccagtaaaaggag t" /listShort="ccpA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2669543) /Source="Nicolas_upshifts" /id="U2306" /multdbtbs="-" /comp="M5" /sig="SigA" /pcomp="0.366633366633367" /psig="0.577422577422577" /xcortree=1443 /SigmaFactorBS="cgcttacaaatcataaacgacataaattcggacattatgaca tttctctacataaaGTGTTTATGCTATAGATAAGgataagtgtatccagtaaaaggag t" /listShort="ccpA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2669545..2669653) /Source="Nicolas_S_feature" /locus_tag="new_3045221_3045329_c" /HighExp="Oxctl, H2O2, Paraq, MG-0.1, MG-0.2, G150, GM 15, Diami, LBGexp, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigB" /TUshortPSig="0.988, 1, 0.974, 1" /TUlongSig="SigH" /TUlongPSig=1 /label="S1139" promotor_-10 complement(2669653..2669672) /Source="Nicolas_upshift_promotors" /id="U2307" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.377622377622378" /psig="0.988011988011988" /xcortree=2336 /SigmaFactorBS="tagttataaaaaccaagtataCGTTTTCatcatctataaaaA CGTGTATAATTTCATGAGAagtaattaaatttgatgaataatgaaaaataatgtacac t" /listShort="S1139, ccpA, ytxD, ytxE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2669653) /Source="Nicolas_upshifts" /id="U2307" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.377622377622378" /psig="0.988011988011988" /xcortree=2336 /SigmaFactorBS="tagttataaaaaccaagtataCGTTTTCatcatctataaaaA CGTGTATAATTTCATGAGAagtaattaaatttgatgaataatgaaaaataatgtacac t" /listShort="S1139, ccpA, ytxD, ytxE" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2669655..2669720) /Source="Nicolas_S_feature" /locus_tag="new_3045331_3045396_c" /HighExp="BMM, GM 120, Diami, GM 90, M/G, GM 25, M9-exp, HiTm, G180, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigB" /TUshortPSig="1, 0.974, 1" /TUlongSig="SigH" /TUlongPSig=1 /label="S1140" promotor_-35 complement(2669686..2669692) /Source="Nicolas_upshift_promotors" /id="U2307" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.377622377622378" /psig="0.988011988011988" /xcortree=2336 /SigmaFactorBS="tagttataaaaaccaagtataCGTTTTCatcatctataaaaA CGTGTATAATTTCATGAGAagtaattaaatttgatgaataatgaaaaataatgtacac t" /listShort="S1139, ccpA, ytxD, ytxE" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2669766) /Source="Nicolas_upshifts" /id="D1533" /incds=0 /nref=66 /ntot=188 /MaxReadThrough="6.10221" /MaxDrop="6.29667" /score="46.0872381" /energy="-11.3" /TU="U2308,U2309,U2310" /idTUdmin="U2311" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(2669769..2670845) /gene="aroX" /locus_tag="BSU_29750" /old_locus_tag="BSU29750" /EC_number="2.5.1.54" /EC_number="5.4.99.5" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:4200844, 7496534, 11444986, 16339761, 28743924" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4200844, 7496534, 11444986, 16339761, 28743924; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional chorismate mutase type II-isozyme 3(regulatory domain); 3-deoxy-D-arabino-heptulosonate7-phosphate synthase" /protein_id="NP_390853.1" /db_xref="EnsemblGenomes-Gn:BSU29750" /db_xref="EnsemblGenomes-Tr:CAB14953" /db_xref="GOA:P39912" /db_xref="InterPro:IPR002701" /db_xref="InterPro:IPR006218" /db_xref="InterPro:IPR006268" /db_xref="InterPro:IPR010954" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR036979" /db_xref="PDB:5GMU" /db_xref="PDB:5GO2" /db_xref="SubtiList:BG10375" /db_xref="UniProtKB/Swiss-Prot:P39912" /translation="MSNTELELLRQKADELNLQILKLINERGNVVKEIGKAKEAQGVN RFDPVRERTMLNNIIENNDGPFENSTIQHIFKEIFKAGLELQEEDHSKALLVSRKKKP EDTIVDIKGEKIGDGQQRFIVGPCAVESYEQVAEVAAAAKKQGIKILRGGAFKPRTSP YDFQGLGVEGLQILKRVADEFDLAVISEIVTPAHIEEALDYIDVIQIGARNMQNFELL KAAGAVKKPVLLKRGLAATISEFINAAEYIMSQGNDQIILCERGIRTYETATRNTLDI SAVPILKQETHLPVFVDVTHSTGRRDLLLPTAKAALAIGADGVMAEVHPDPSVALSDS AQQMAIPEFEKWLNELKPMVKVNA*" /label="aroX CDS" gene complement(2669769..2670845) /gene="aroX" /locus_tag="BSU_29750" /old_locus_tag="BSU29750" /label="aroX gene" promotor_-10 complement(2670886..2670905) /Source="Nicolas_upshift_promotors" /id="U2308" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=3058 /SigmaFactorBS="taataaagtagagtttttataaaattttttgtatttcagTAT TTCCAtttggaattacttaTAGTAAGATGCATGATAACTacaaaataaaaaatgaatg t" /listShort="aroA, S1140, S1139, ccpA, ytxD" /listLong="ytxE" /label="promotor_-10" upshifts complement(2670906) /Source="Nicolas_upshifts" /id="U2308" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=3058 /SigmaFactorBS="taataaagtagagtttttataaaattttttgtatttcagTAT TTCCAtttggaattacttaTAGTAAGATGCATGATAACTacaaaataaaaaatgaatg t" /listShort="aroA, S1140, S1139, ccpA, ytxD" /listLong="ytxE" /label="upshifts" S_feature complement(2670908..2671008) /Source="Nicolas_S_feature" /locus_tag="new_3046584_3046684_c" /HighExp="Lbtran, BMM, dia5, GM 25, GM 90, M9-exp, MG 150, Diami, MG-0.2, SMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB, SigH" /TUshortPSig="0.974, 1, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1141" promotor_-35 complement(2670920..2670927) /Source="Nicolas_upshift_promotors" /id="U2308" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=3058 /SigmaFactorBS="taataaagtagagtttttataaaattttttgtatttcagTAT TTCCAtttggaattacttaTAGTAAGATGCATGATAACTacaaaataaaaaatgaatg t" /listShort="aroA, S1140, S1139, ccpA, ytxD" /listLong="ytxE" /label="promotor_-35" downshifts 2670942 /Source="Nicolas_upshifts" /id="D1534" /incds=0 /nref=1 /ntot=9 /MaxReadThrough="2.07872" /MaxDrop="3.23284" /score="1.10447256" /energy="-7.6" /TU="NA" /idTUdmin="U2304" /TUdmin=4071 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2670996..2671015) /Source="Nicolas_upshift_promotors" /id="U2309" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.453546453546454" /psig="0.974025974025974" /xcortree=3018 /SigmaFactorBS="agatatcatctggcgcttttttttgtaaaaaacCCTTGAAca ttgccctcacaTCATGTAGGATAGCTTCATAgattactttatcacttaaaagcgtttg g" /listShort="S1141, aroA, S1140, S1139, ccpA, ytxD, ytxE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2671008) /Source="Nicolas_upshifts" /id="U2309" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.453546453546454" /psig="0.974025974025974" /xcortree=3018 /SigmaFactorBS="agatatcatctggcgcttttttttgtaaaaaacCCTTGAAca ttgccctcacaTCATGTAGGATAGCTTCATAgattactttatcacttaaaagcgtttg g" /listShort="S1141, aroA, S1140, S1139, ccpA, ytxD, ytxE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2671029..2671035) /Source="Nicolas_upshift_promotors" /id="U2309" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.453546453546454" /psig="0.974025974025974" /xcortree=3018 /SigmaFactorBS="agatatcatctggcgcttttttttgtaaaaaacCCTTGAAca ttgccctcacaTCATGTAGGATAGCTTCATAgattactttatcacttaaaagcgtttg g" /listShort="S1141, aroA, S1140, S1139, ccpA, ytxD, ytxE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2671081..2671407) /gene="brxJ" /locus_tag="BSU_29760" /old_locus_tag="BSU29760" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8733232, 22938038, 25852656" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8733232, 22938038, 25852656; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bacilliredoxin involved in debacillithiolation" /protein_id="NP_390854.1" /db_xref="EnsemblGenomes-Gn:BSU29760" /db_xref="EnsemblGenomes-Tr:CAB14954" /db_xref="InterPro:IPR022551" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG10373" /db_xref="UniProtKB/Swiss-Prot:P39914" /translation="MAKQLIQSEEEFKRIAEQEGVFVFLKHSTTCPISQAAFHEFDAF ANQHEDVPAYYLQVQEARPLSNFIAETYGVKHESPQIFIIQNGEVKWHTSHSQITEAA IEQHLS*" /label="brxJ CDS" gene complement(2671081..2671407) /gene="brxJ" /locus_tag="BSU_29760" /old_locus_tag="BSU29760" /label="brxJ gene" downshifts complement(2671090) /Source="Nicolas_upshifts" /id="D1535" /incds=0 /nref=144 /ntot=286 /MaxReadThrough="7.09736" /MaxDrop="5.96753" /score="13.8032115" /energy="-7.6" /TU="U2310,U2311" /idTUdmin="U2313" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" CDS complement(2671431..2671886) /gene="ytxH" /locus_tag="BSU_29770" /old_locus_tag="BSU29770" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 8733232, 16291680" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390855.2" /db_xref="EnsemblGenomes-Gn:BSU29770" /db_xref="EnsemblGenomes-Tr:CAB14955" /db_xref="InterPro:IPR024623" /db_xref="SubtiList:BG10975" /db_xref="UniProtKB/Swiss-Prot:P40780" /translation="MSKDGINSKDFLIGTLIGGIIGATTALFLAPKSGKELRDDLGSQ AVALRDKTDKMTADAKEKGTQYVSIAKDKTSNITQLVADQSGQIMNKVKDLRDRSKSD KTDSSTAMQDMREEAMQAADETKDQVLQTKEDVKDELKDAQKQAEQLNR*" /label="ytxH CDS" gene complement(2671431..2671886) /gene="ytxH" /locus_tag="BSU_29770" /old_locus_tag="BSU29770" /label="ytxH gene" CDS complement(2671917..2672339) /gene="ytxG" /locus_tag="BSU_29780" /old_locus_tag="BSU29780" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8733232, 22720735, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8733232, 22720735, 26735940; Product type f: factor" /codon_start=1 /transl_table=11 /product="general stress protein" /protein_id="NP_390856.2" /db_xref="EnsemblGenomes-Gn:BSU29780" /db_xref="EnsemblGenomes-Tr:CAB14956" /db_xref="GOA:P40779" /db_xref="InterPro:IPR009293" /db_xref="SubtiList:BG10974" /db_xref="UniProtKB/Swiss-Prot:P40779" /translation="MIIILYLSVALIAVAFLVLVIYLSKTLKSLQLTLKNVASTLEGL EGQMKGITTETAELLHKTNRLAEDIQEKSEKLNTVVHAVQGVGASVQQFNTSMKQAAG SVSASVRENQDKINQVVTWSQAAMEIWEKWKQKKKSAL*" /label="ytxG CDS" gene complement(2671917..2672339) /gene="ytxG" /locus_tag="BSU_29780" /old_locus_tag="BSU29780" /label="ytxG gene" promotor_-10 complement(2672360..2672378) /Source="Nicolas_upshift_promotors" /id="U2310" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=264 /SigmaFactorBS="taacggagaatagtatgtatacagcccagtacacaTGTTTAT gattgaagaaaacGGGTAAACAGCAGTATATCctgcagcaaggaggtttgagatgatt a" /listShort="ytxG, ytxH, ytxJ, S1141, aroA, S1140, S1139, ccpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2672373) /Source="Nicolas_upshifts" /id="U2310" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=264 /SigmaFactorBS="taacggagaatagtatgtatacagcccagtacacaTGTTTAT gattgaagaaaacGGGTAAACAGCAGTATATCctgcagcaaggaggtttgagatgatt a" /listShort="ytxG, ytxH, ytxJ, S1141, aroA, S1140, S1139, ccpA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2672392..2672398) /Source="Nicolas_upshift_promotors" /id="U2310" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=264 /SigmaFactorBS="taacggagaatagtatgtatacagcccagtacacaTGTTTAT gattgaagaaaacGGGTAAACAGCAGTATATCctgcagcaaggaggtttgagatgatt a" /listShort="ytxG, ytxH, ytxJ, S1141, aroA, S1140, S1139, ccpA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2672412..2672430) /Source="Nicolas_upshift_promotors" /id="U2311" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=552 /SigmaFactorBS="tgctttttatttatctgatgggaaagcttattAAAGGATTTt cttacataaCGGAGAATAGTATGTATACagcccagtacacatgtttatgattgaagaa a" /listShort="ytxG, ytxH, ytxJ, S1141, aroA" /listLong="S1140, S1139, ccpA" /label="promotor_-10" upshifts complement(2672421) /Source="Nicolas_upshifts" /id="U2311" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=552 /SigmaFactorBS="tgctttttatttatctgatgggaaagcttattAAAGGATTTt cttacataaCGGAGAATAGTATGTATACagcccagtacacatgtttatgattgaagaa a" /listShort="ytxG, ytxH, ytxJ, S1141, aroA" /listLong="S1140, S1139, ccpA" /label="upshifts" promotor_-35 complement(2672441..2672449) /Source="Nicolas_upshift_promotors" /id="U2311" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=552 /SigmaFactorBS="tgctttttatttatctgatgggaaagcttattAAAGGATTTt cttacataaCGGAGAATAGTATGTATACagcccagtacacatgtttatgattgaagaa a" /listShort="ytxG, ytxH, ytxJ, S1141, aroA" /listLong="S1140, S1139, ccpA" /label="promotor_-35" CDS complement(2672501..2673799) /gene="murC" /locus_tag="BSU_29790" /old_locus_tag="BSU29790" /EC_number="6.3.2.8" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10565540, 12682299, 12781748; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetyl muramate-alanine ligase" /protein_id="NP_390857.1" /db_xref="EnsemblGenomes-Gn:BSU29790" /db_xref="EnsemblGenomes-Tr:CAB14957" /db_xref="GOA:P40778" /db_xref="InterPro:IPR000713" /db_xref="InterPro:IPR004101" /db_xref="InterPro:IPR005758" /db_xref="InterPro:IPR013221" /db_xref="InterPro:IPR036565" /db_xref="InterPro:IPR036615" /db_xref="SubtiList:BG10973" /db_xref="UniProtKB/Swiss-Prot:P40778" /translation="MTVYHFVGIKGTGMSPLAQILHDNGYTVQGSDIEKFIFTQTALE KRNITILPFSAENIKPGMTVIAGNAFPDTHPEIEKAMSEGIPVIRYHKFLGDYMKKFT SVAVTGAHGKTSTTGLLAHVIQNAKPTSFLIGDGTGQGNENSEYFVFEACEYRRHFLS YQPDYAIMTNIDFDHPDYFSSIDDVFDAFQEMALQVNKGIIACGDDEHLPKIHANVPV VYYGTGEENDFQARNIVKSTEGTTFDVFVRNTFYDTFYIPAYGHHNVLNSLAVIALCH YEEIDSSIIKHALKSFGGVKRRFNEKQLGDQVLIDDYAHHPTEIKVTIEAARQKYPDR EIVAVFQPHTFTRTQQFLDEFAESLSGADCVYLCDIFGSARENAGKLTIGDLQGKIHN AKLIEEDDTSVLKAHDKAVLIFMGAGDIQKYMRAYENVMA*" /label="murC CDS" gene complement(2672501..2673799) /gene="murC" /locus_tag="BSU_29790" /old_locus_tag="BSU29790" /label="murC gene" downshifts complement(2672510) /Source="Nicolas_upshifts" /id="D1536" /incds=0 /nref=29 /ntot=180 /MaxReadThrough="5.23049" /MaxDrop="5.42617" /score="15.3729968" /energy="-7.5" /TU="U2313,U2314" /idTUdmin="U2312" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2673824..2673843) /Source="Nicolas_upshift_promotors" /id="U2312" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1225 /SigmaFactorBS="agggaggcttttcagccgccGCGGTCGCAAattgaaatgagc GTCATATACTGGGGAACAGAtagacgtttgttggaggtacaattatgactgtttatca t" /listShort="murC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2673825) /Source="Nicolas_upshifts" /id="U2312" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1225 /SigmaFactorBS="agggaggcttttcagccgccGCGGTCGCAAattgaaatgagc GTCATATACTGGGGAACAGAtagacgtttgttggaggtacaattatgactgtttatca t" /listShort="murC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2673827..2674023) /Source="Nicolas_S_feature" /locus_tag="new_3049503_3049699_c" /HighExp="Cold, G150, G135, dia15, G180, H2O2, C30, Oxctl, Paraq, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="SigA" /TUlongPSig="0.938" /label="S1142" promotor_-35 complement(2673856..2673865) /Source="Nicolas_upshift_promotors" /id="U2312" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1225 /SigmaFactorBS="agggaggcttttcagccgccGCGGTCGCAAattgaaatgagc GTCATATACTGGGGAACAGAtagacgtttgttggaggtacaattatgactgtttatca t" /listShort="murC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2674006..2674025) /Source="Nicolas_upshift_promotors" /id="U2313" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.755244755244755" /psig=1 /xcortree=2585 /SigmaFactorBS="tgctgatcacagcaagtgatttaataaacgaataatatggGT TCATTttcacaccaaaCATGGTATGATAGTGTTTAGagcatttaacagctatgccgct t" /listShort="S1142, murC, ytxG, ytxH, ytxJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2674023) /Source="Nicolas_upshifts" /id="U2313" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.755244755244755" /psig=1 /xcortree=2585 /SigmaFactorBS="tgctgatcacagcaagtgatttaataaacgaataatatggGT TCATTttcacaccaaaCATGGTATGATAGTGTTTAGagcatttaacagctatgccgct t" /listShort="S1142, murC, ytxG, ytxH, ytxJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2674037..2674043) /Source="Nicolas_upshift_promotors" /id="U2313" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.755244755244755" /psig=1 /xcortree=2585 /SigmaFactorBS="tgctgatcacagcaagtgatttaataaacgaataatatggGT TCATTttcacaccaaaCATGGTATGATAGTGTTTAGagcatttaacagctatgccgct t" /listShort="S1142, murC, ytxG, ytxH, ytxJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2674049..2676907) /gene="sftA" /locus_tag="BSU_29805" /old_locus_tag="BSU29805" /function="8.1: DNA replication, recombination, and repair" /experiment="publication(s) with functional evidences, PMID:3129532, 11134515, 11208805, 19788545, 28110333" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3129532, 11134515, 11208805, 19788545, 28110333; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="DNA translocase" /protein_id="NP_390859.2" /db_xref="EnsemblGenomes-Gn:BSU29805" /db_xref="EnsemblGenomes-Tr:CAB14959" /db_xref="GOA:C0SP86" /db_xref="InterPro:IPR002543" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR018541" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13906" /db_xref="UniProtKB/Swiss-Prot:C0SP86" /translation="MSWLHKFFDLFLGESEEDAERETKPAQIPQQQEVHHPEGQLKRL EDPKIYYEYPKGKFRFPVVPDGYKNHDLRRRRTPSDEPKSAPRPSAAPYRERPRNEEE QHTYQAAEPAKKPFKPTNIPSPVYGFNQKPSVKKDVPKKPSETLNEPDKSVKEKVTLL SEEIERERGYPASDTQAHSKIESPFFPDTQFEKQPSGVLNRKDTEHDEALAKRPAEPS GNKVPFESGVQQPEKEEPFFPAEQAEEQTPPEMLTDTAAEGLSDSEVGREEPATAEEE QREQQPEKFEEPVFSAELDEEQTAPESQTEAVSEDEKAKEPSDSPVYNHHENAAEGAE SPFVQEEQMDIRQEEPLFTDHEYSSEALAQAETVAKESEEPSESIINNHYDTLGEAQE TKIDVQPDSHTELEKTEHMEQGSKSSTATLENRQEIRADKPREASEEPKKRPGVQEKR TEQSASSQKGPSVPFNVMMLKRDTHKQQKAEERRGSYVFPNVALLDVPPAQVQDDTAW IEEQRQLLDLTLKNFNVRANVVHVTQGPSVTRFEVHPEPGVKVNKITNLSDDIKLSLS AKDIRIEAPIPGKNTIGIEVPNRTSKVVDLRQMIRSSAFRTSKSPLTAALGLDISGNP VVIDLKKMPHGLIAGATGSGKSVCINTILVSLLYKADPSEVKVLLIDPKMVELAPYNK IPHLVSPVITDAKAATAALKWVVEEMERRYELFAHSGVRDIDRFNQLTAEHQMGEKLP YLVVIIDELADLMMVAPNDVEESIARIAQKARACGIHLLVATQRPSVDVITGLIKANI PTRIAFSVSSQVDSRTIIDIAGAEKLLGKGDMLFLENGSGKPVRLQGNFVSDREIDRV VSHVRSQMPPTYLFEQEELVRQGSALKEEDELFYEACEFVVEQNSASTSSLQRRFRIG YNRAARLIDMMEAEGMISEAKGSKPREVLITASDLINE*" /label="sftA CDS" gene complement(2674049..2676907) /gene="sftA" /locus_tag="BSU_29805" /old_locus_tag="BSU29805" /label="sftA gene" promotor_-10 complement(2676941..2676960) /Source="Nicolas_upshift_promotors" /id="U2314" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2568 /SigmaFactorBS="tttagcggctttgtttctgctgatagcttaaTCTTTtctggg ccgaccagcAGTGGTATACTAAAAACCGTcccagaaaactataagggagttagagata a" /listShort="ytpS, S1142, murC, ytxG, ytxH, ytxJ" /listLong="S1141, aroA" /label="promotor_-10" upshifts complement(2676951) /Source="Nicolas_upshifts" /id="U2314" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2568 /SigmaFactorBS="tttagcggctttgtttctgctgatagcttaaTCTTTtctggg ccgaccagcAGTGGTATACTAAAAACCGTcccagaaaactataagggagttagagata a" /listShort="ytpS, S1142, murC, ytxG, ytxH, ytxJ" /listLong="S1141, aroA" /label="upshifts" promotor_-35 complement(2676976..2676980) /Source="Nicolas_upshift_promotors" /id="U2314" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2568 /SigmaFactorBS="tttagcggctttgtttctgctgatagcttaaTCTTTtctggg ccgaccagcAGTGGTATACTAAAAACCGTcccagaaaactataagggagttagagata a" /listShort="ytpS, S1142, murC, ytxG, ytxH, ytxJ" /listLong="S1141, aroA" /label="promotor_-35" downshifts complement(2677050) /Source="Nicolas_upshifts" /id="D1537" /incds=0 /nref=186 /ntot=249 /MaxReadThrough="4.47299" /MaxDrop="6.35097" /score="9.62039509" /energy="-14.5" /TU="U2315" /idTUdmin="U2315" /TUdmin="-1553" /isTUend="FALSE" /label="downshifts" CDS complement(2677067..2677672) /gene="ytpR" /locus_tag="BSU_29820" /old_locus_tag="BSU29820" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 21949854, 27435445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative tRNA binding enzyme" /protein_id="NP_390860.1" /db_xref="EnsemblGenomes-Gn:BSU29820" /db_xref="EnsemblGenomes-Tr:CAB14960" /db_xref="GOA:O34943" /db_xref="InterPro:IPR002547" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR027855" /db_xref="InterPro:IPR033714" /db_xref="InterPro:IPR037154" /db_xref="SubtiList:BG13905" /db_xref="UniProtKB/Swiss-Prot:O34943" /translation="MNAFYNKEGVGDTLLISLQDVTREQLGYEKHGDVVKIFNNETKE TTGFNIFNASSYLTIDENGPVALSETFVQDVNEILNRNGVEETLVVDLSPKFVVGYVE SKEKHPNADKLSVCKVNVGEETLQIVCGAPNVDQGQKVVVAKVGAVMPSGLVIKDAEL RGVPSSGMICSAKELDLPDAPAEKGILVLEGDYEAGDAFQF*" /label="ytpR CDS" gene complement(2677067..2677672) /gene="ytpR" /locus_tag="BSU_29820" /old_locus_tag="BSU29820" /label="ytpR gene" CDS complement(2677688..2678497) /gene="ytpQ" /locus_tag="BSU_29830" /old_locus_tag="BSU29830" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12719520, 21949854" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (iron homeostasis)" /protein_id="NP_390861.1" /db_xref="EnsemblGenomes-Gn:BSU29830" /db_xref="EnsemblGenomes-Tr:CAB14961" /db_xref="InterPro:IPR010838" /db_xref="SubtiList:BG13904" /db_xref="UniProtKB/Swiss-Prot:O34496" /translation="MKMTSRKLSDILKQRLQHENRSFLFDREKDTLRVEDQTTKKGIT LDLPPIIAKWELKKDEAIDEIVYYVSEAMTAMEGKAQEMTGKETRIYPVIRSTSFPDK SSEDIPLIYDDHTAETRIYYALDLGKTYRLIDQRMLEKENWTKERIRETAAFNLRSLP TVVKEDTVAGNYFYFFRANDGYDASRILNEAILNEYKQHAEGELAISVPHQDVLILAD IRNESGYDILGQMSMSFFAGGTVPITALSFLYNEGKLEPVFILAKSRPKKD*" /label="ytpQ CDS" gene complement(2677688..2678497) /gene="ytpQ" /locus_tag="BSU_29830" /old_locus_tag="BSU29830" /label="ytpQ gene" CDS complement(2678512..2678835) /gene="ytpP" /locus_tag="BSU_29840" /old_locus_tag="BSU29840" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12719520, 15937154, 21949854; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thiol-disulfide oxidoreductase with thioredoxin domain" /protein_id="NP_390862.1" /db_xref="EnsemblGenomes-Gn:BSU29840" /db_xref="EnsemblGenomes-Tr:CAB14962" /db_xref="GOA:O34357" /db_xref="InterPro:IPR005746" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG13903" /db_xref="UniProtKB/Swiss-Prot:O34357" /translation="MKKIESTQELEKAVKDDWSVFMFSADWCPDCRFVEPFLPELEAN FPEFTYYYVDRDKFIDTCAEWEIYGIPSFVVFNEGKEVNRFVSKDRKTKEEIEQFLTD SLAKA*" /label="ytpP CDS" gene complement(2678512..2678835) /gene="ytpP" /locus_tag="BSU_29840" /old_locus_tag="BSU29840" /label="ytpP gene" S_feature complement(2678836..2678974) /Source="Nicolas_S_feature" /locus_tag="new_3054512_3054650_c" /HighExp="G180, G150, Paraq, Oxctl, H2O2, Diami, C90, dia15, G135, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.32150299999999998" /TUshortSig="SigA" /TUshortPSig="0.938" /TUlongSig="NA" /TUlongPSig="NA" /label="S1143" CDS complement(2678874..2678990) /locus_tag="BSU_29845" /old_locus_tag="BSU29845" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513998.1" /translation="MQIKYDNDNGKANLTYSFVAYKWFCLKQFGMIQMDEYR*" /label="hypothetical protein CDS" gene complement(2678874..2678990) /locus_tag="BSU_29845" /old_locus_tag="BSU29845" /label="gene" promotor_-10 complement(2678961..2678980) /Source="Nicolas_upshift_promotors" /id="U2315" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.515484515484515" /psig="0.938061938061938" /xcortree=2564 /SigmaFactorBS="atttcaccctcatgtacacgatgttaaacgaaacgagcTtga taatgcaaataaAATATGATAATGATAATGGGaaagccaatcttacatattcattcgt t" /listShort="S1143, ytpP, ytpQ, ytpR, ytpS" /listLong="S1142, murC, ytxG, ytxH, ytxJ" /label="promotor_-10" upshifts complement(2678974) /Source="Nicolas_upshifts" /id="U2315" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.515484515484515" /psig="0.938061938061938" /xcortree=2564 /SigmaFactorBS="atttcaccctcatgtacacgatgttaaacgaaacgagcTtga taatgcaaataaAATATGATAATGATAATGGGaaagccaatcttacatattcattcgt t" /listShort="S1143, ytpP, ytpQ, ytpR, ytpS" /listLong="S1142, murC, ytxG, ytxH, ytxJ" /label="upshifts" promotor_-35 2678982..2678989 /Source="Nicolas_upshift_promotors" /id="U2316" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.925074925074925" /psig="0.98101898101898" /xcortree=2351 /SigmaFactorBS="aagattggctttcccattatcattatcatatttTATTTGCAt tatcaagctcgttTCGTTTAACATCGTGTACATgagggtgaaatttacagatggatat a" /listShort="ytoQ, S1144" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2679004..2679023 /Source="Nicolas_upshift_promotors" /id="U2316" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.925074925074925" /psig="0.98101898101898" /xcortree=2351 /SigmaFactorBS="aagattggctttcccattatcattatcatatttTATTTGCAt tatcaagctcgttTCGTTTAACATCGTGTACATgagggtgaaatttacagatggatat a" /listShort="ytoQ, S1144" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2679009 /Source="Nicolas_upshifts" /id="U2316" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.925074925074925" /psig="0.98101898101898" /xcortree=2351 /SigmaFactorBS="aagattggctttcccattatcattatcatatttTATTTGCAt tatcaagctcgttTCGTTTAACATCGTGTACATgagggtgaaatttacagatggatat a" /listShort="ytoQ, S1144" /GFF_Attribute="listLong" /label="upshifts" CDS 2679070..2679516 /gene="ytoQ" /locus_tag="BSU_29850" /old_locus_tag="BSU29850" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme with sugar binding fold" /protein_id="NP_390863.1" /db_xref="EnsemblGenomes-Gn:BSU29850" /db_xref="EnsemblGenomes-Tr:CAB14963" /db_xref="InterPro:IPR019884" /db_xref="SubtiList:BG13899" /db_xref="UniProtKB/Swiss-Prot:O34305" /translation="MEFIVYLAGEIHSNWREEIKEKTKSLKLPITFVGPMENHDRSDN IGEEIMGVQPNAVLKDDKASDINNFRTAVLMNKADFVIALFGEKYKQWNTAMDASYAI AKGKPLIIIRPESLHHPLKELSNKANITVETVNQAIKALSYLFETE*" /label="ytoQ CDS" gene 2679070..2679516 /gene="ytoQ" /locus_tag="BSU_29850" /old_locus_tag="BSU29850" /label="ytoQ gene" S_feature 2679517..2680245 /Source="Nicolas_S_feature" /locus_tag="new_3055193_3055921" /HighExp="H2O2, dia15, C30, C90, Diami, S1, M0t45, Salt, Paraq, Lbexp" /AntisenseName="ytoP" /AntisenseCor="0.35418735783791" /AntisenseRegPval="-8.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.981" /TUlongSig="NA" /TUlongPSig="NA" /label="S1144" CDS complement(2679571..2680644) /gene="ytoP" /locus_tag="BSU_29860" /old_locus_tag="BSU29860" /EC_number="3.4.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8535515; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative modified amino acid aminopeptidase" /protein_id="NP_390864.1" /db_xref="EnsemblGenomes-Gn:BSU29860" /db_xref="EnsemblGenomes-Tr:CAB14964" /db_xref="GOA:O34924" /db_xref="InterPro:IPR008007" /db_xref="InterPro:IPR023367" /db_xref="SubtiList:BG13898" /db_xref="UniProtKB/Swiss-Prot:O34924" /translation="MNQETKALFQTLTQLPGAPGNEHQVRAFMKQELAKYADDIVQDR LGSVFGVRRGAEDAPRIMVAGHMDEVGFMVTSITDNGLLRFQTLGGWWSQVLLAQRVE IQTDNGPVPGVISSIPPHLLTDAQRNRPMDIKNMMIDIGADDKEDAIKIGIRPGQQIV PVCPFTTMANEKKILSKAWDNRYGCGLSIELLKELHGKELPNTLYAGATVQEEVGLRG AQTASHMIKPDLFFALDASPANDMSGDKNEFGQLGKGFLLRILDRTTVMHRGMREFVL DMAETHDIPYQYFVSGGGTDAGKVHISNSGVPSAVIGICSRYIHTNATIIHIDDYAAA KEMLIKLVTACDKQTVDAIKENM*" /label="ytoP CDS" gene complement(2679571..2680644) /gene="ytoP" /locus_tag="BSU_29860" /old_locus_tag="BSU29860" /label="ytoP gene" downshifts complement(2679590) /Source="Nicolas_upshifts" /id="D1538" /incds=0 /nref=140 /ntot=248 /MaxReadThrough="1.89952" /MaxDrop="4.55096" /score="14.9571314" /energy="-14.4" /TU="NA" /idTUdmin="U2317" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2680666..2680685) /Source="Nicolas_upshift_promotors" /id="U2317" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.701298701298701" /psig="0.998001998001998" /xcortree=2339 /SigmaFactorBS="ctgatcgagcagattgggtcagagTGCTTGGAaaacttcatt gttTCTAATAAAATAAAAGGACTacatagaaatgaggggaaaacatgaatcaagaaac g" /listShort="ytoP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2680670) /Source="Nicolas_upshifts" /id="U2317" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.701298701298701" /psig="0.998001998001998" /xcortree=2339 /SigmaFactorBS="ctgatcgagcagattgggtcagagTGCTTGGAaaacttcatt gttTCTAATAAAATAAAAGGACTacatagaaatgaggggaaaacatgaatcaagaaac g" /listShort="ytoP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2680699..2680706) /Source="Nicolas_upshift_promotors" /id="U2317" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.701298701298701" /psig="0.998001998001998" /xcortree=2339 /SigmaFactorBS="ctgatcgagcagattgggtcagagTGCTTGGAaaacttcatt gttTCTAATAAAATAAAAGGACTacatagaaatgaggggaaaacatgaatcaagaaac g" /listShort="ytoP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2680741..2680744 /Source="Nicolas_upshift_promotors" /id="U2318" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.922077922077922" /psig=1 /xcortree=3184 /SigmaFactorBS="gcactctgacccaatctgctcgatcagccgcgtattgCTTAa caggatttggctgTTTCTGTATAATGAAAAGTAcgatcaaccaggaggtgctttattt t" /listShort="ytzB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2680759..2680778 /Source="Nicolas_upshift_promotors" /id="U2318" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.922077922077922" /psig=1 /xcortree=3184 /SigmaFactorBS="gcactctgacccaatctgctcgatcagccgcgtattgCTTAa caggatttggctgTTTCTGTATAATGAAAAGTAcgatcaaccaggaggtgctttattt t" /listShort="ytzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2680764 /Source="Nicolas_upshifts" /id="U2318" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.922077922077922" /psig=1 /xcortree=3184 /SigmaFactorBS="gcactctgacccaatctgctcgatcagccgcgtattgCTTAa caggatttggctgTTTCTGTATAATGAAAAGTAcgatcaaccaggaggtgctttattt t" /listShort="ytzB" /GFF_Attribute="listLong" /label="upshifts" CDS 2680803..2681120 /gene="ytzB" /locus_tag="BSU_29870" /old_locus_tag="BSU29870" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390865.1" /db_xref="EnsemblGenomes-Gn:BSU29870" /db_xref="EnsemblGenomes-Tr:CAB14965" /db_xref="InterPro:IPR025711" /db_xref="SubtiList:BG13936" /db_xref="UniProtKB/Swiss-Prot:O32065" /translation="MKLRHLLLGAGLGICTAVVVRQYVMKPYISSEKALRIVKSAFKQ RGPIDGSWIYTQPEPYNINGETVQVYKTGITRSAFGELEQYEVMVDAKTGEIVDVIDT IAS*" /label="ytzB CDS" gene 2680803..2681120 /gene="ytzB" /locus_tag="BSU_29870" /old_locus_tag="BSU29870" /label="ytzB gene" downshifts 2681120 /Source="Nicolas_upshifts" /id="D1539" /incds=0 /nref=250 /ntot=259 /MaxReadThrough="1.29231" /MaxDrop="7.83082" /score="44.9062865" /energy="-17" /TU="NA" /idTUdmin="U2318" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2681173..2682873) /gene="maeC" /locus_tag="BSU_29880" /old_locus_tag="BSU29880" /EC_number="1.1.1.38" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:16788182, 20933603, 22740702, 23136871, 24325460" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16788182, 20933603, 22740702, 23136871, 24325460; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NAD-dependent malic enzyme (conversion of malateinto pyruvate)" /protein_id="NP_390866.1" /db_xref="EnsemblGenomes-Gn:BSU29880" /db_xref="EnsemblGenomes-Tr:CAB14966" /db_xref="GOA:O34389" /db_xref="InterPro:IPR001891" /db_xref="InterPro:IPR012301" /db_xref="InterPro:IPR012302" /db_xref="InterPro:IPR015884" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR037062" /db_xref="SubtiList:BG12614" /db_xref="UniProtKB/Swiss-Prot:O34389" /translation="MKQFRVTNEGDIQTTLRGLEVLSVPFLNKGVAFTEEERKELGLK GFLPPKVLTIDDQAKRAYEQYSAQPDDLSKNVYLTALHDRNETLFYRLLNDHLGEMLP IVYTPTVGTAIQRYSHEYRKPRGLYLSIDDPDGMKEAFKQYKDQSDTIDLIVATDAEG ILGIGDWGVGGIAISIGKLAVYTAAAGIDPSRVLAVVLDAGTNQESLLNDPLYVGNQH SRVRGERYDQFIDDYVALARETFPNALLHWEDFGAKNARSILKRYKDKVCTFNDDIQG TGAVSLAAVLSCAKASKVPLRDHRVVIFGAGTAGIGIAEQLREALVREGLSEEESYKR FWCIDRNGLLTDDMDQLLDFQKPYARSADEVKDYQRNGDGGGIDLLEVVRQAKPTILI GTSTVSGAFTEEIVKEMASHVKRPAILPMSNPTTLSEAKPEDLIEWTEGRALITTGSP FPPVEYNGVTYHIGQANNALVFPGLGLGTIVTKSKLITDGMFEACARAIAGMVNVGVP GAPMLPKVEDLRTVSATVAVEVAKTAMKEGVATEEPEDIIQAVQDAMWYPVYKPIRAI *" /label="maeC CDS" gene complement(2681173..2682873) /gene="maeC" /locus_tag="BSU_29880" /old_locus_tag="BSU29880" /label="maeC gene" downshifts complement(2681192) /Source="Nicolas_upshifts" /id="D1540" /incds=0 /nref=77 /ntot=255 /MaxReadThrough="2.4872" /MaxDrop="4.99085" /score="17.675308" /energy="-15.3" /TU="NA" /idTUdmin="U2319" /TUdmin="-18" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2682905..2682923) /Source="Nicolas_upshift_promotors" /id="U2319" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=724 /SigmaFactorBS="aagcgaatgaagcgatagcatatttttaTGTTTACcctgcat gttttccGGCTAATAATGCAAACCTAgtactattatgctcagaaaggaagaggcaggg t" /listShort="malS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2682912) /Source="Nicolas_upshifts" /id="U2319" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=724 /SigmaFactorBS="aagcgaatgaagcgatagcatatttttaTGTTTACcctgcat gttttccGGCTAATAATGCAAACCTAgtactattatgctcagaaaggaagaggcaggg t" /listShort="malS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2682938..2682944) /Source="Nicolas_upshift_promotors" /id="U2319" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=724 /SigmaFactorBS="aagcgaatgaagcgatagcatatttttaTGTTTACcctgcat gttttccGGCTAATAATGCAAACCTAgtactattatgctcagaaaggaagaggcaggg t" /listShort="malS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2682955..2683725) /gene="ytnP" /locus_tag="BSU_29890" /old_locus_tag="BSU29890" /EC_number="3.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22101040, 24268182; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative quorum-quenching lactonase" /protein_id="NP_390867.1" /db_xref="EnsemblGenomes-Gn:BSU29890" /db_xref="EnsemblGenomes-Tr:CAB14967" /db_xref="GOA:O34760" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG13895" /db_xref="UniProtKB/Swiss-Prot:O34760" /translation="MFGVVPKPLWSKKYPVNEKNQIELRTDPILIQKDGLNIIIDAGI GYGKLTDKQKRNYGVTQESNVKPSLAALGLTVADIDVIAMTHLHFDHACGLTEYEGER LVSVFPNAVIYTSAVEWDEMRHPNIRSKNTYWKENWEAVAGQVKTFEDTLTITEGITM HHTGGHSDGHSVLICEDAGETAVHMADLMPTHAHRNPLWVLAYDDYPMTSIPQKQKWQ AFAAEKDAWFIFYHDAEYRALQWEEDGSIKKSVKRMKR*" /label="ytnP CDS" gene complement(2682955..2683725) /gene="ytnP" /locus_tag="BSU_29890" /old_locus_tag="BSU29890" /label="ytnP gene" S_feature complement(2683726..2683814) /Source="Nicolas_S_feature" /locus_tag="new_3059402_3059490_c" /HighExp="HiOs, M40t90, T0.30H, T1.30H, T3.0H, T1.0H, Sw, T2.30H, T3.30H, Gly" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1145" promotor_-10 complement(2683812..2683831) /Source="Nicolas_upshift_promotors" /id="U2320" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.497502497502497" /psig="0.997002997002997" /xcortree=3207 /SigmaFactorBS="gtaaagacagactctgacaggagTCTGTtttttttatgggcc gTTTGCTACCATGATGATAGGggggggtgaaaatggaaacaatgaaaattggaaacat c" /listShort="S1145, ytnP, malS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2683814) /Source="Nicolas_upshifts" /id="U2320" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.497502497502497" /psig="0.997002997002997" /xcortree=3207 /SigmaFactorBS="gtaaagacagactctgacaggagTCTGTtttttttatgggcc gTTTGCTACCATGATGATAGGggggggtgaaaatggaaacaatgaaaattggaaacat c" /listShort="S1145, ytnP, malS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2683847..2683851) /Source="Nicolas_upshift_promotors" /id="U2320" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.497502497502497" /psig="0.997002997002997" /xcortree=3207 /SigmaFactorBS="gtaaagacagactctgacaggagTCTGTtttttttatgggcc gTTTGCTACCATGATGATAGGggggggtgaaaatggaaacaatgaaaattggaaacat c" /listShort="S1145, ytnP, malS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2683871..2684512) /gene="trmB" /locus_tag="BSU_29900" /old_locus_tag="BSU29900" /EC_number="2.1.1.33" /function="16.6: Maintain" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15789416, 16600901, 17150909, 19934251" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15789416, 16600901, 17150909, 19934251; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA (guanine-N(7)-)-methyltransferase" /protein_id="NP_390868.1" /db_xref="EnsemblGenomes-Gn:BSU29900" /db_xref="EnsemblGenomes-Tr:CAB14968" /db_xref="GOA:O34522" /db_xref="InterPro:IPR003358" /db_xref="InterPro:IPR029063" /db_xref="PDB:2FCA" /db_xref="SubtiList:BG13890" /db_xref="UniProtKB/Swiss-Prot:O34522" /translation="MRMRHKPWADDFLAENADIAISNPADYKGKWNTVFGNDNPIHIE VGTGKGQFISGMAKQNPDINYIGIELFKSVIVTAVQKVKDSEAQNVKLLNIDADTLTD VFEPGEVKRVYLNFSDPWPKKRHEKRRLTYSHFLKKYEEVMGKGGSIHFKTDNRGLFE YSLKSFSEYGLLLTYVSLDLHNSNLEGNIMTEYEEKFSALGQPIYRAEVEWRT*" /label="trmB CDS" gene complement(2683871..2684512) /gene="trmB" /locus_tag="BSU_29900" /old_locus_tag="BSU29900" /label="trmB gene" downshifts complement(2683881) /Source="Nicolas_upshifts" /id="D1541" /incds=0 /nref=46 /ntot=131 /MaxReadThrough="3.31031" /MaxDrop="5.64644" /score="29.2137061" /energy="-10.1" /TU="NA" /idTUdmin="U2321" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" downshifts complement(2683946) /Source="Nicolas_upshifts" /id="D1542" /incds=1 /nref=39 /ntot=202 /MaxReadThrough="6.31908" /MaxDrop="3.64275" /score="29.2137061" /energy="-10.1" /TU="U2321,U2323" /idTUdmin="U2323" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2684538..2684557) /Source="Nicolas_upshift_promotors" /id="U2321" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.916083916083916" /psig="0.999000999001" /xcortree=2613 /SigmaFactorBS="ggccttaagagagatacactggaaaaacgaGCTTGcgggtct ttttaattCATGGTATGTTGTTAGTCGAaataatagatagaggtgtcaatcatatgag a" /listShort="trmB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2684547) /Source="Nicolas_upshifts" /id="U2321" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.916083916083916" /psig="0.999000999001" /xcortree=2613 /SigmaFactorBS="ggccttaagagagatacactggaaaaacgaGCTTGcgggtct ttttaattCATGGTATGTTGTTAGTCGAaataatagatagaggtgtcaatcatatgag a" /listShort="trmB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2684549..2684997) /Source="Nicolas_S_feature" /locus_tag="new_3060225_3060673_c" /HighExp="C30, Cold, G135, G180, B60, Paraq, G150, Oxctl, H2O2, LBGstat" /AntisenseName="ytzH" /AntisenseCor="-0.51149457663808795" /AntisenseRegPval="-18.600000000000001" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigD, SigA" /TUlongPSig="1, 0.992" /label="S1146" promotor_-35 complement(2684573..2684577) /Source="Nicolas_upshift_promotors" /id="U2321" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.916083916083916" /psig="0.999000999001" /xcortree=2613 /SigmaFactorBS="ggccttaagagagatacactggaaaaacgaGCTTGcgggtct ttttaattCATGGTATGTTGTTAGTCGAaataatagatagaggtgtcaatcatatgag a" /listShort="trmB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2684656..2684662 /Source="Nicolas_upshift_promotors" /id="U2322" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=942 /SigmaFactorBS="agggtcccgtctgctggaacactcctttcccaTGTATAAaaa cgctctgttttGAACAATTTAACccgtatgatactgaagggatgtgtaccgttatggg t" /listShort="ytzH, S1147" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2684677..2684688 /Source="Nicolas_upshift_promotors" /id="U2322" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=942 /SigmaFactorBS="agggtcccgtctgctggaacactcctttcccaTGTATAAaaa cgctctgttttGAACAATTTAACccgtatgatactgaagggatgtgtaccgttatggg t" /listShort="ytzH, S1147" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2684684 /Source="Nicolas_upshifts" /id="U2322" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=942 /SigmaFactorBS="agggtcccgtctgctggaacactcctttcccaTGTATAAaaa cgctctgttttGAACAATTTAACccgtatgatactgaagggatgtgtaccgttatggg t" /listShort="ytzH, S1147" /GFF_Attribute="listLong" /label="upshifts" CDS 2684719..2684997 /gene="ytzH" /locus_tag="BSU_29910" /old_locus_tag="BSU29910" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390869.1" /db_xref="EnsemblGenomes-Gn:BSU29910" /db_xref="EnsemblGenomes-Tr:CAB14969" /db_xref="InterPro:IPR025547" /db_xref="SubtiList:BG13942" /db_xref="UniProtKB/Swiss-Prot:O32066" /translation="MGLHYEHQVHLLKDILTDHQLDCCGTVAEYEQLERVIKSLMANT ELDSNFKNVLEDVYRYSQSGISSKSIDSHIQEHQNSLSQWVEQMDSYS*" /label="ytzH CDS" gene 2684719..2684997 /gene="ytzH" /locus_tag="BSU_29910" /old_locus_tag="BSU29910" /label="ytzH gene" S_feature 2684998..2685168 /Source="Nicolas_S_feature" /locus_tag="new_3060674_3060844" /HighExp="S5, S7, S8, S6, S4, BT, C30, nit, ferm, G/S" /AntisenseName="ytmP" /AntisenseCor="-0.32108027439793901" /AntisenseRegPval="-7.1" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1147" CDS complement(2684998..2685612) /gene="ytmP" /locus_tag="BSU_29920" /old_locus_tag="BSU29920" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9026440, 11545674; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative kinase/phosphotransferase" /protein_id="NP_390870.2" /db_xref="EnsemblGenomes-Gn:BSU29920" /db_xref="EnsemblGenomes-Tr:CAB14970" /db_xref="GOA:C0SPC1" /db_xref="InterPro:IPR002575" /db_xref="InterPro:IPR011009" /db_xref="SubtiList:BG13889" /db_xref="UniProtKB/Swiss-Prot:C0SPC1" /translation="MENGDVITAQHWMTGRELKPKDMSGRPVAELLRKIHTSKALLDM LKRLGKEPLNPGALLSQLKQAVFAVQQSSPLIQEGIKYLEEHLHEVHFGEKVVCHCDV NHNNWLLSEDNQLYLIDWDGAMIADPAMDLGPLLYHYVEKPAWESWLSMYGIELTESL RLRMAWYVLSETITFIAWHKAKGNDKEFHDAMEELHILMKRIVD*" /label="ytmP CDS" gene complement(2684998..2685612) /gene="ytmP" /locus_tag="BSU_29920" /old_locus_tag="BSU29920" /label="ytmP gene" downshifts 2685146 /Source="Nicolas_upshifts" /id="D1543" /incds=1 /nref=4 /ntot=35 /MaxReadThrough="2.54837" /MaxDrop="3.82368" /score="-4.89809956" /energy="-11.3" /TU="NA" /idTUdmin="U2322" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2685613..2685948) /Source="Nicolas_S_feature" /locus_tag="new_3061289_3061624_c" /HighExp="T1.30H, M9-stat, T2.30H, T3.0H, UNK1, B60, T2.0H, T3.30H, T1.0H, GM-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigD, SigA" /TUlongPSig="1, 0.992" /label="S1148" promotor_-10 complement(2685940..2685959) /Source="Nicolas_upshift_promotors" /id="U2323" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.855144855144855" /psig="0.999000999001" /xcortree=2288 /SigmaFactorBS="atatttagcatcagatcttaagagtttTGCTTGACgaagttt gtgctatAGCGCTAAAATTTAAAGGACggctattgattagcatatgagactctcaata g" /listShort="S1148, ytmP, S1146, trmB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2685948) /Source="Nicolas_upshifts" /id="U2323" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.855144855144855" /psig="0.999000999001" /xcortree=2288 /SigmaFactorBS="atatttagcatcagatcttaagagtttTGCTTGACgaagttt gtgctatAGCGCTAAAATTTAAAGGACggctattgattagcatatgagactctcaata g" /listShort="S1148, ytmP, S1146, trmB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2685974..2685981) /Source="Nicolas_upshift_promotors" /id="U2323" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.855144855144855" /psig="0.999000999001" /xcortree=2288 /SigmaFactorBS="atatttagcatcagatcttaagagtttTGCTTGACgaagttt gtgctatAGCGCTAAAATTTAAAGGACggctattgattagcatatgagactctcaata g" /listShort="S1148, ytmP, S1146, trmB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2685975..2688131) /gene="amyX" /locus_tag="BSU_29930" /old_locus_tag="BSU29930" /EC_number="3.2.1.41" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9453151, 16582490, 19465663, 23973973" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9453151, 16582490, 19465663, 23973973; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pullulanase" /protein_id="NP_390871.2" /db_xref="EnsemblGenomes-Gn:BSU29930" /db_xref="EnsemblGenomes-Tr:CAB14971" /db_xref="GOA:C0SPA0" /db_xref="InterPro:IPR004193" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR011840" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR014756" /db_xref="InterPro:IPR017853" /db_xref="PDB:2E8Y" /db_xref="PDB:2E8Z" /db_xref="PDB:2E9B" /db_xref="SubtiList:BG12566" /db_xref="UniProtKB/Swiss-Prot:C0SPA0" /translation="MVSIRRSFEAYVDDMNIITVLIPAEQKEIMTPPFRLETEITDFP LAVREEYSLEAKYKYVCVSDHPVTFGKIHCVRASSGHKTDLQIGAVIRTAAFDDEFYY DGELGAVYTADHTVFKVWAPAATSAAVKLSHPNKSGRTFQMTRLEKGVYAVTVTGDLH GYEYLFCICNNSEWMETVDQYAKAVTVNGEKGVVLRPDQMKWTAPLKPFSHPVDAVIY ETHLRDFSIHENSGMINKGKYLALTETDTQTANGSSSGLAYVKELGVTHVELLPVNDF AGVDEEKPLDAYNWGYNPLHFFAPEGSYASNPHDPQTRKTELKQMINTLHQHGLRVIL DVVFNHVYKRENSPFEKTVPGYFFRHDECGMPSNGTGVGNDIASERRMARKFIADCVV YWLEEYNVDGFRFDLLGILDIDTVLYMKEKATKAKPGILLFGEGWDLATPLPHEQKAA LANAPRMPGIGFFNDMFRDAVKGNTFHLKATGFALGNGESAQAVMHGIAGSSGWKALA PIVPEPSQSINYVESHDNHTFWDKMSFALPQENDSRKRSRQRLAAAIILLAQGVPFIH SGQEFFRTKQGVENSYQSSDSINQLDWDRRETFKEDVHYIRRLISLRKAHPAFRLRSA ADIQRHLECLTLKEHLIAYRLYDLDEVDEWKDIIVIHHASPDSVEWRLPNDIPYRLLC DPSGFQEDPTEIKKTVAVNGIGTVILYLASDLKSFA*" /label="amyX CDS" gene complement(2685975..2688131) /gene="amyX" /locus_tag="BSU_29930" /old_locus_tag="BSU29930" /label="amyX gene" Polymorphism join(2687672,2687674) /Source="geneious" /ID="SNP_BsDelta6_3063349_3063349" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change /CDS_Position=459 /Change="A -> G" /Codon_Change="GTT -> GTC" /Coverage=168 /locus_tag="BSU_29930" /Protein_Effect="None" /Reference_Frequency="1.2%" /Reference_Nucleotides="A" /Variant_Nucleotides="G" /Variant_P_Value=0 /Variant_Raw_Frequency=165 /comment="silent" /modified_by="User" / /label="Polymorphism_Delta6" CDS complement(2688157..2689086) /gene="ytlR" /locus_tag="BSU_29940" /old_locus_tag="BSU29940" /EC_number="2.7.1.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phospholipid kinase" /protein_id="NP_390872.1" /db_xref="EnsemblGenomes-Gn:BSU29940" /db_xref="EnsemblGenomes-Tr:CAB14972" /db_xref="GOA:O34799" /db_xref="InterPro:IPR001206" /db_xref="InterPro:IPR005218" /db_xref="InterPro:IPR016064" /db_xref="InterPro:IPR017438" /db_xref="SubtiList:BG13880" /db_xref="UniProtKB/Swiss-Prot:O34799" /translation="MSHWFFIINPTAGHRNGLRVWKSIQKELIKRKVEHRSFLTEHPG HAEVLARQISTIQEYKLKRLIVIGGDGTMHEVVNGLKDVDDIELSFVPAGAYNDFSRG FSIKKIDLIQEIKKVKRPLTRTFHLGSVNFLQDKSQILYFMNHIGIGFDAYVNKKAME FPLRRVFLFLRLRFLVYPLSHLHASATFKPFTLACTTEDETREFHDVWFAVVSNHPFY GGGMKAAPLANPREKTFDIVIVENQPFLKKYWLLCLMAFGKHTKMDGVTMFKAKDITF YTKDKIPFHADGEIMGTTPFRLASSPSPLRIKT*" /label="ytlR CDS" gene complement(2688157..2689086) /gene="ytlR" /locus_tag="BSU_29940" /old_locus_tag="BSU29940" /label="ytlR gene" CDS complement(2689135..2690049) /gene="ytlQ" /locus_tag="BSU_29950" /old_locus_tag="BSU29950" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390873.1" /db_xref="EnsemblGenomes-Gn:BSU29950" /db_xref="EnsemblGenomes-Tr:CAB14973" /db_xref="InterPro:IPR012397" /db_xref="SubtiList:BG13879" /db_xref="UniProtKB/Swiss-Prot:O34471" /translation="MAQIIKIHDYISRYELDPYHYINQFVRLKKERWLSLVEAAERQH EERQASAEEPEPVQKRKKFSLKRRKEEIKADIQEERHQWFEDEEDIHVRLPKSRVALA SFYKRHLYDFQLKWASSTLSEISQLSNQVKQDRILRYLTQQLPDSYFIMYKPVLKIQQ AAVELSIVIISPLEIYCVSFLEAEEDSVYIGSKNRFWDKKTASQTASVLNPGLSLFRT DSVVSKIVKEKQAEIPVRKLLLSRTSYIDYPEPPYGLEIADKRSAEEWIERQKKNTAP IKHHQVKAAKALLSYCMSDSYRRQEWLE*" /label="ytlQ CDS" gene complement(2689135..2690049) /gene="ytlQ" /locus_tag="BSU_29950" /old_locus_tag="BSU29950" /label="ytlQ gene" promotor_-10 complement(2689812..2689830) /Source="Nicolas_upshift_promotors" /id="U2324" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2820 /SigmaFactorBS="tgcagaaacgaaaaaaattttcattgaaaaGAAGAAAagaag agataaaaGCCGATATACAAGAAGAGAgacaccaatggtttgaggacgaagaagatat t" /listShort="ytlR, amyX" /listLong="S1148, ytmP, S1146, trmB" /label="promotor_-10" upshifts complement(2689820) /Source="Nicolas_upshifts" /id="U2324" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2820 /SigmaFactorBS="tgcagaaacgaaaaaaattttcattgaaaaGAAGAAAagaag agataaaaGCCGATATACAAGAAGAGAgacaccaatggtttgaggacgaagaagatat t" /listShort="ytlR, amyX" /listLong="S1148, ytmP, S1146, trmB" /label="upshifts" promotor_-35 complement(2689844..2689850) /Source="Nicolas_upshift_promotors" /id="U2324" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2820 /SigmaFactorBS="tgcagaaacgaaaaaaattttcattgaaaaGAAGAAAagaag agataaaaGCCGATATACAAGAAGAGAgacaccaatggtttgaggacgaagaagatat t" /listShort="ytlR, amyX" /listLong="S1148, ytmP, S1146, trmB" /label="promotor_-35" CDS complement(2690075..2690626) /gene="ytlP" /locus_tag="BSU_29960" /old_locus_tag="BSU29960" /EC_number="3.1.4.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17012785; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA 2',3'-cyclic phosphodiesterase" /protein_id="NP_390874.1" /db_xref="EnsemblGenomes-Gn:BSU29960" /db_xref="EnsemblGenomes-Tr:CAB14974" /db_xref="GOA:O34570" /db_xref="InterPro:IPR004175" /db_xref="InterPro:IPR009097" /db_xref="SubtiList:BG13878" /db_xref="UniProtKB/Swiss-Prot:O34570" /translation="MPDIRPHYFIGVPIPEGIANPIYQAAKNEPILTFQKWVHPLDYH ITLIFLGAADETQIKKLEGSLAEIASEIDPFSIKFGKIDVFGDRRKPRVLHLEPKKNK TLDRLREHTKQAVLQAGFQVEKRPYHPHMTLARKWTGEDGFPAHVPFESGEVSMMAER FSLFQIHLNQSPKYEEIFKFQLS*" /label="ytlP CDS" gene complement(2690075..2690626) /gene="ytlP" /locus_tag="BSU_29960" /old_locus_tag="BSU29960" /label="ytlP gene" misc_feature 2690489..2690508 /Source="Nicolas_upshift_promotors" /id="U2325" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.962037962037962" /psig="0.996003996003996" /xcortree=2127 /SigmaFactorBS="tagcgaaccttcaagcttctttatttgtgtctcatccgccgc tccgagaaaaattaaCGTGATATGATAGTCAAGCGggtgcacccatttttgaaacgtc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2690492 /Source="Nicolas_upshifts" /id="U2325" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.962037962037962" /psig="0.996003996003996" /xcortree=2127 /SigmaFactorBS="tagcgaaccttcaagcttctttatttgtgtctcatccgccgc tccgagaaaaattaaCGTGATATGATAGTCAAGCGggtgcacccatttttgaaacgtc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2690649..2690668) /Source="Nicolas_upshift_promotors" /id="U2326" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.423576423576424" /psig="0.992007992007992" /xcortree=2211 /SigmaFactorBS="cgtttgtgcgagagtgttttcatacactgttcctCTATccgc acagcctctttATTGATAAAATAATAGCTGTcaaagaagggagtgtcagacggatgcc a" /listShort="ytlP, ytlQ, ytlR, amyX" /listLong="S1148, ytmP, S1146, trmB" /label="promotor_-10" upshifts complement(2690661) /Source="Nicolas_upshifts" /id="U2326" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.423576423576424" /psig="0.992007992007992" /xcortree=2211 /SigmaFactorBS="cgtttgtgcgagagtgttttcatacactgttcctCTATccgc acagcctctttATTGATAAAATAATAGCTGTcaaagaagggagtgtcagacggatgcc a" /listShort="ytlP, ytlQ, ytlR, amyX" /listLong="S1148, ytmP, S1146, trmB" /label="upshifts" promotor_-35 complement(2690684..2690687) /Source="Nicolas_upshift_promotors" /id="U2326" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.423576423576424" /psig="0.992007992007992" /xcortree=2211 /SigmaFactorBS="cgtttgtgcgagagtgttttcatacactgttcctCTATccgc acagcctctttATTGATAAAATAATAGCTGTcaaagaagggagtgtcagacggatgcc a" /listShort="ytlP, ytlQ, ytlR, amyX" /listLong="S1148, ytmP, S1146, trmB" /label="promotor_-35" promotor_-35 2690709..2690716 /Source="Nicolas_upshift_promotors" /id="U2327" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig="0.999000999001" /xcortree=1889 /SigmaFactorBS="ggctgtgcggatagaggaacagtgtatgaaaacacTCTCGCA CaaacgtttatTATGTTAGGATATTATATGAcacttgttttattcagaaaggaatgac a" /listShort="ytkP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2690727..2690746 /Source="Nicolas_upshift_promotors" /id="U2327" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig="0.999000999001" /xcortree=1889 /SigmaFactorBS="ggctgtgcggatagaggaacagtgtatgaaaacacTCTCGCA CaaacgtttatTATGTTAGGATATTATATGAcacttgttttattcagaaaggaatgac a" /listShort="ytkP" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2690730..2690741) /Source="Nicolas_upshift_promotors" /id="U2328" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=895 /SigmaFactorBS="atcagctgtgtttgcaacgattttcaacattgtcattccttt cTGAATAAaacaagtgtcataTAATATCCTAACataataaacgtttgtgcgagagtgt t" /listShort="ytlP, ytlQ, ytlR, amyX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2690734 /Source="Nicolas_upshifts" /id="U2327" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig="0.999000999001" /xcortree=1889 /SigmaFactorBS="ggctgtgcggatagaggaacagtgtatgaaaacacTCTCGCA CaaacgtttatTATGTTAGGATATTATATGAcacttgttttattcagaaaggaatgac a" /listShort="ytkP" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2690744) /Source="Nicolas_upshifts" /id="U2328" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=895 /SigmaFactorBS="atcagctgtgtttgcaacgattttcaacattgtcattccttt cTGAATAAaacaagtgtcataTAATATCCTAACataataaacgtttgtgcgagagtgt t" /listShort="ytlP, ytlQ, ytlR, amyX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2690755..2690761) /Source="Nicolas_upshift_promotors" /id="U2328" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=895 /SigmaFactorBS="atcagctgtgtttgcaacgattttcaacattgtcattccttt cTGAATAAaacaagtgtcataTAATATCCTAACataataaacgtttgtgcgagagtgt t" /listShort="ytlP, ytlQ, ytlR, amyX" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2690775..2691710 /gene="ytkP" /locus_tag="BSU_29970" /old_locus_tag="BSU29970" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12193636, 16267287; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative cysteine synthase-like enzyme" /protein_id="NP_390875.1" /db_xref="EnsemblGenomes-Gn:BSU29970" /db_xref="EnsemblGenomes-Tr:CAB14975" /db_xref="GOA:O34476" /db_xref="InterPro:IPR001216" /db_xref="InterPro:IPR001926" /db_xref="InterPro:IPR005856" /db_xref="InterPro:IPR005859" /db_xref="InterPro:IPR036052" /db_xref="SubtiList:BG13872" /db_xref="UniProtKB/Swiss-Prot:O34476" /translation="MLKIVANTADLIGDTPLVRLNRLQPENAAQVYLKLEFFNPSGSV KDRAAYQMIIEAEQNGLLKPGSVIIEPTSGNTGIGLAMNAAARGYKAILVMPDTMTKE RINLLKAYGAEVVLTPGEERMPGSIKKAKELAEQIPNSYIPMQFDNTANPDAHRKTTA PEIARAIEEIGKPLGAFVASSGTGGTITGTGEALKELFPDITVHVVEPAGSPVLSGGK PGAHKLVGTSPGFIPPILNEDVYDEIIKISDEDAYTTTRRLAAEEGILVGPSSGAACF AAIETAKRLSPDKVVVCMTADTGERYLSTDLWSFI*" /label="ytkP CDS" gene 2690775..2691710 /gene="ytkP" /locus_tag="BSU_29970" /old_locus_tag="BSU29970" /label="ytkP gene" downshifts 2691686 /Source="Nicolas_upshifts" /id="D1544" /incds=0 /nref=74 /ntot=225 /MaxReadThrough="2.5873" /MaxDrop="4.59197" /score="29.2734118" /energy="-18.2" /TU="NA" /idTUdmin="U2327" /TUdmin="-16" /isTUend="TRUE" /label="downshifts" CDS complement(2691744..2693135) /gene="ytjP" /locus_tag="BSU_29980" /old_locus_tag="BSU29980" /EC_number="3.5.-.-" /EC_number="3.4.13.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7528082, 27435445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative promiscuous peptidase/deacylase" /protein_id="NP_390876.1" /db_xref="EnsemblGenomes-Gn:BSU29980" /db_xref="EnsemblGenomes-Tr:CAB14976" /db_xref="GOA:O34944" /db_xref="InterPro:IPR001261" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR010964" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG13867" /db_xref="UniProtKB/Swiss-Prot:O34944" /translation="MNWEVEVIRKKEDLIRDTQEFLRINSVMDETTAGPGKPFGEGVN ASLTSLLELGEKEGFTTKNLDGFAGHIEWGEGDDIIGVLCHVDVVPPGDGWTSDPFSA EIRNGRIYARGAIDDKGPTMAAFYALKIVKDMNLPLSKRVRMIIGTDEESDWRCVEHY FKHEEMPTMGFAPDADFPIINAEKGIIDASLLIPHRPNQAEPKAVLVSFQSGLRLNMV PDAAEAVIEGPKNEEILSSFKDMLRTTDQKGEAAIENGQLILRMYGLSCHAMEPNNGI NAGILLCEFLQQTELDDAGKRFVQVVTDKFSGDTRGKKLDIDCEDEISGELTLNVGTL RYKEGQGGELGINIRYPVTAESKVIRDTFESASEFELGEFKDSKPHHVSADHPLVKTL QKVYEGQLGKKADLISIGGGTYARSLKAGVAFGPLFPGRPDSAHQKDEYIEIDDLLRS TALYAQAIYELAK*" /label="ytjP CDS" gene complement(2691744..2693135) /gene="ytjP" /locus_tag="BSU_29980" /old_locus_tag="BSU29980" /label="ytjP gene" downshifts complement(2691756) /Source="Nicolas_upshifts" /id="D1545" /incds=0 /nref=63 /ntot=240 /MaxReadThrough="3.38616" /MaxDrop="3.73023" /score="23.9099234" /energy="-14.4" /TU="U2330" /idTUdmin="U2330" /TUdmin="-330" /isTUend="FALSE" /label="downshifts" S_feature complement(2693136..2693576) /Source="Nicolas_S_feature" /locus_tag="new_3068812_3069252_c" /HighExp="Etha, Salt, M40t90, Lbtran, T1.30H, M0t90, Lbstat, T1.0H, T0.30H, LBGstat" /AntisenseName="pbuO" /AntisenseCor="-0.324692399913451" /AntisenseRegPval="-7.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1149" promotor_-35 2693162..2693167 /Source="Nicolas_upshift_promotors" /id="U2329" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.403596403596404" /psig="0.994005994005994" /xcortree=2633 /SigmaFactorBS="ataatgatcccctttccgcaagaaatgaCTTGCAaaaaccaa ataaaACGAATAATATTAATGGTGTtttgttaaaacgttcgtaattggaggatactat g" /listShort="pbuO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2693181..2693200 /Source="Nicolas_upshift_promotors" /id="U2329" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.403596403596404" /psig="0.994005994005994" /xcortree=2633 /SigmaFactorBS="ataatgatcccctttccgcaagaaatgaCTTGCAaaaaccaa ataaaACGAATAATATTAATGGTGTtttgttaaaacgttcgtaattggaggatactat g" /listShort="pbuO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2693194 /Source="Nicolas_upshifts" /id="U2329" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.403596403596404" /psig="0.994005994005994" /xcortree=2633 /SigmaFactorBS="ataatgatcccctttccgcaagaaatgaCTTGCAaaaaccaa ataaaACGAATAATATTAATGGTGTtttgttaaaacgttcgtaattggaggatactat g" /listShort="pbuO" /GFF_Attribute="listLong" /label="upshifts" CDS 2693232..2694530 /gene="pbuO" /locus_tag="BSU_29990" /old_locus_tag="BSU29990" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11591660, 12923093, 15849754, 16850406, 19446032, 28583948" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11591660, 12923093, 15849754, 16850406, 19446032, 28583948; Product type t : transporter" /codon_start=1 /transl_table=11 /product="hypoxanthine/guanine permease" /protein_id="NP_390877.1" /db_xref="EnsemblGenomes-Gn:BSU29990" /db_xref="EnsemblGenomes-Tr:CAB14977" /db_xref="GOA:O34978" /db_xref="InterPro:IPR006043" /db_xref="InterPro:IPR026033" /db_xref="SubtiList:BG13864" /db_xref="UniProtKB/Swiss-Prot:O34978" /translation="MFHLKEQQTSIKQEIIAGLTTFFTMVYIVVVNPVILANAGVPFD QVFTATIIASIVGTLWMALAANYPIAIAPGMGLNAYLAFHVVSASDGGITYATAFSAV FTAGVLFIILSLTPLRKQLIEAIPNNLKYGITTGIGLFIAFIGLRQAGIVAADESNLV TLGNLHSPGVILTLVGLLISVVLMVLNVSGALFIGMAATALIAFFTGQLHFSKGFMSL PHLPEGLMISNPFTAFGDVIHHGLYAVVFSFLLVTIFDTTGTMIGVAEQAGLMKNNKL PNVRKALLADSTATTVGAVFGTSPTTAFIESSAGVAAGGRTGLTALTVAVMFAASMFF SPLVSALSGIAAITSPALIIVGSLMMGSVSNMNWKEMDEAFPAFLVILAMPLTSSIST GIALGFISYPIVKAARGKWREIHPLVIVFAILFFIQLFIL*" /label="pbuO CDS" gene 2693232..2694530 /gene="pbuO" /locus_tag="BSU_29990" /old_locus_tag="BSU29990" /label="pbuO gene" promotor_-10 complement(2693553..2693572) /Source="Nicolas_upshift_promotors" /id="U2330" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.5004995004995" /psig="0.997002997002997" /xcortree=3182 /SigmaFactorBS="tgttgtgatcccgtattttaaattgtttggaatcgcttctat aAGTTGTTttcttaaaggcgttAACGATAGAATAATGAAGAGaacccctgctgtaaat a" /listShort="S1149, ytjP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2693576) /Source="Nicolas_upshifts" /id="U2330" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.5004995004995" /psig="0.997002997002997" /xcortree=3182 /SigmaFactorBS="tgttgtgatcccgtattttaaattgtttggaatcgcttctat aAGTTGTTttcttaaaggcgttAACGATAGAATAATGAAGAGaacccctgctgtaaat a" /listShort="S1149, ytjP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2693587..2693593) /Source="Nicolas_upshift_promotors" /id="U2330" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.5004995004995" /psig="0.997002997002997" /xcortree=3182 /SigmaFactorBS="tgttgtgatcccgtattttaaattgtttggaatcgcttctat aAGTTGTTttcttaaaggcgttAACGATAGAATAATGAAGAGaacccctgctgtaaat a" /listShort="S1149, ytjP" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2694517 /Source="Nicolas_upshifts" /id="D1546" /incds=0 /nref=43 /ntot=178 /MaxReadThrough="2.37859" /MaxDrop="5.35341" /score="16.9979166" /energy="-10.2" /TU="NA" /idTUdmin="U2329" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2694570..2695727) /gene="ythQ" /locus_tag="BSU_30000" /old_locus_tag="BSU30000" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (permease)" /protein_id="NP_390878.1" /db_xref="EnsemblGenomes-Gn:BSU30000" /db_xref="EnsemblGenomes-Tr:CAB14978" /db_xref="GOA:O35029" /db_xref="InterPro:IPR010288" /db_xref="SubtiList:BG13861" /db_xref="UniProtKB/Swiss-Prot:O35029" /translation="MNGRTLFFRRLFDYYKYQFKVLHAVIDWTVALYIVLPAIAFVIY QYIDLMNGRGLLYEWSEVAEWRWLYAVCVLIMFTGSIRTFLMEADKVFLLQKKEIIYQ LKRYALLYSFLATLAKWLLLFFIVLPLISHSVLITFAESTALLCYLFGLHIFFLSLKQ DRIRKPRSISRWIGDTLVRAILFAGSAILIVFTERHLLALFGILFLFFSVIRSLKKTA SFTAFEAEVTEEKKSRLALAGLVMMMSQEAGMPKVKDRMRRKPLLYRNSKRIFKRRTI CTGYKELFFKVMLRNGEYARQMYMLLSAFTVLIFVSPIWLKVIALLVYTGVCRYILTL IFDKVMDAPFLIGTDKESDEYYRARKSCINILHYAFAACCFLAAAVSLLFT*" /label="ythQ CDS" gene complement(2694570..2695727) /gene="ythQ" /locus_tag="BSU_30000" /old_locus_tag="BSU30000" /label="ythQ gene" downshifts complement(2694595) /Source="Nicolas_upshifts" /id="D1547" /incds=0 /nref=1 /ntot=153 /MaxReadThrough="3.07175" /MaxDrop="3.89104" /score="19.8243425" /energy="-11.2" /TU="NA" /idTUdmin="U2332" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2694843..2694848 /Source="Nicolas_upshift_promotors" /id="U2331" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1395 /SigmaFactorBS="gtgaaagctgacagtagcatgtacatctgcctTGCATActcg ccattcctcaGCATAACTTTAAAAAACAActccttatagcctgtgcagatcgttcgtc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2694863..2694881 /Source="Nicolas_upshift_promotors" /id="U2331" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1395 /SigmaFactorBS="gtgaaagctgacagtagcatgtacatctgcctTGCATActcg ccattcctcaGCATAACTTTAAAAAACAActccttatagcctgtgcagatcgttcgtc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2694871 /Source="Nicolas_upshifts" /id="U2331" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1395 /SigmaFactorBS="gtgaaagctgacagtagcatgtacatctgcctTGCATActcg ccattcctcaGCATAACTTTAAAAAACAActccttatagcctgtgcagatcgttcgtc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2695724..2696434) /gene="ythP" /locus_tag="BSU_30010" /old_locus_tag="BSU30010" /EC_number="3.6.3.-" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_390879.1" /db_xref="EnsemblGenomes-Gn:BSU30010" /db_xref="EnsemblGenomes-Tr:CAB14979" /db_xref="GOA:O34977" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13860" /db_xref="UniProtKB/Swiss-Prot:O34977" /translation="MTNLLEASIEQAGYTSRKKVLTDVFLEVRKGELVGLIGANGAGK STAIKAILGLSEDFKGHIAWNDCSFAYIPEHPSFYEELTLWEHLDLISTLHGIEESEF AHRAQSLLQTFSLDHVKHELPVTFSKGMQQKLMLIQAFLSKPDMYVIDEPFIGLDPIS TKRFVDMLKAEKERGAGILMCTHVLDTAEKICDRFYMIEKGSLFLQGTLKDVQDKTGL EGQSLLDCFYKAVQGDRL*" /label="ythP CDS" gene complement(2695724..2696434) /gene="ythP" /locus_tag="BSU_30010" /old_locus_tag="BSU30010" /label="ythP gene" promotor_-10 complement(2696448..2696463) /Source="Nicolas_upshift_promotors" /id="U2332" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1669 /SigmaFactorBS="ttggattactatgtatttcggctcaatattattatggttaaA GAAACTTTTtttattctattTCGTAGTAAATTTTGGaggtgagtgagttttgacaaat t" /listShort="ythP, ythQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2696465) /Source="Nicolas_upshifts" /id="U2332" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1669 /SigmaFactorBS="ttggattactatgtatttcggctcaatattattatggttaaA GAAACTTTTtttattctattTCGTAGTAAATTTTGGaggtgagtgagttttgacaaat t" /listShort="ythP, ythQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2696475..2696484) /Source="Nicolas_upshift_promotors" /id="U2332" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1669 /SigmaFactorBS="ttggattactatgtatttcggctcaatattattatggttaaA GAAACTTTTtttattctattTCGTAGTAAATTTTGGaggtgagtgagttttgacaaat t" /listShort="ythP, ythQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2696491..2696492 /Source="Nicolas_upshift_promotors" /id="U2333" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.583416583416583" /psig="0.583416583416583" /xcortree=956 /SigmaFactorBS="acctccaaaatttactacgaaatagaataaaaaaagtttctt taaccATaataatattgagccgaaatACATAGTAATCcaacaaggatggctgcccaac g" /listShort="S1150, S1151, ytzE" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2696504..2696609 /Source="Nicolas_S_feature" /locus_tag="new_3072180_3072285" /HighExp="S5, S4, S3, S8, S7, S6, G/S, Pyr, T5.0H, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.583" /TUlongSig="NA" /TUlongPSig="NA" /label="S1150" upshifts 2696504 /Source="Nicolas_upshifts" /id="U2333" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.583416583416583" /psig="0.583416583416583" /xcortree=956 /SigmaFactorBS="acctccaaaatttactacgaaatagaataaaaaaagtttctt taaccATaataatattgagccgaaatACATAGTAATCcaacaaggatggctgcccaac g" /listShort="S1150, S1151, ytzE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2696512..2696522 /Source="Nicolas_upshift_promotors" /id="U2333" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.583416583416583" /psig="0.583416583416583" /xcortree=956 /SigmaFactorBS="acctccaaaatttactacgaaatagaataaaaaaagtttctt taaccATaataatattgagccgaaatACATAGTAATCcaacaaggatggctgcccaac g" /listShort="S1150, S1151, ytzE" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2696575..2696581 /Source="Nicolas_upshift_promotors" /id="U2334" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.497502497502497" /psig=1 /xcortree=399 /SigmaFactorBS="tggaaaaaattaataggagttatcCCTAGATtcatcactgca ataTCGTGTATAATGAGGGCGAAttattttaacaattacagatgtctgcctttgttgc t" /listShort="S1151, ytzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2696596..2696615 /Source="Nicolas_upshift_promotors" /id="U2334" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.497502497502497" /psig=1 /xcortree=399 /SigmaFactorBS="tggaaaaaattaataggagttatcCCTAGATtcatcactgca ataTCGTGTATAATGAGGGCGAAttattttaacaattacagatgtctgcctttgttgc t" /listShort="S1151, ytzE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2696611..2696724 /Source="Nicolas_S_feature" /locus_tag="new_3072287_3072400" /HighExp="S4, S5, M0t90, S3, Etha, M9-stat, M40t90, LPhT, Heat, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 0.583" /TUlongSig="NA" /TUlongPSig="NA" /label="S1151" upshifts 2696611 /Source="Nicolas_upshifts" /id="U2334" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.497502497502497" /psig=1 /xcortree=399 /SigmaFactorBS="tggaaaaaattaataggagttatcCCTAGATtcatcactgca ataTCGTGTATAATGAGGGCGAAttattttaacaattacagatgtctgcctttgttgc t" /listShort="S1151, ytzE" /GFF_Attribute="listLong" /label="upshifts" CDS 2696725..2696946 /gene="ytzE" /locus_tag="BSU_30020" /old_locus_tag="BSU30020" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12618461; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (DeoR family)" /protein_id="NP_390880.1" /db_xref="EnsemblGenomes-Gn:BSU30020" /db_xref="EnsemblGenomes-Tr:CAB14980" /db_xref="GOA:O32067" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13939" /db_xref="UniProtKB/Swiss-Prot:O32067" /translation="MKPSTNRMLTRIKSVYMFIQEKGLVTTQELVDEFGITPRTIQRD LNVLAYNDLVHSPSRGKWETTRKKVKITS*" /label="ytzE CDS" gene 2696725..2696946 /gene="ytzE" /locus_tag="BSU_30020" /old_locus_tag="BSU30020" /label="ytzE gene" downshifts 2696929 /Source="Nicolas_upshifts" /id="D1548" /incds=0 /nref=166 /ntot=259 /MaxReadThrough="4.38243" /MaxDrop="4.90218" /score="20.9755494" /energy="-13.5" /TU="U2333,U2334" /idTUdmin="U2333" /TUdmin="-54" /isTUend="FALSE" /label="downshifts" downshifts 2696998 /Source="Nicolas_upshifts" /id="D1549" /incds=0 /nref=44 /ntot=172 /MaxReadThrough="-0.189589999999999" /MaxDrop="6.00369" /score="20.9755494" /energy="-13.5" /TU="NA" /idTUdmin="U2334" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(2697067..2697786) /gene="rsuA" /locus_tag="BSU_30035" /old_locus_tag="BSU30035" /EC_number="4.2.1.70" /function="16.6: Maintain" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11953756, 16511038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="16S rRNA pseudouridylate 516 synthase" /protein_id="NP_390882.2" /db_xref="EnsemblGenomes-Gn:BSU30035" /db_xref="EnsemblGenomes-Tr:CAB14982" /db_xref="GOA:O32068" /db_xref="InterPro:IPR000748" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR006145" /db_xref="InterPro:IPR018496" /db_xref="InterPro:IPR020103" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG13941" /db_xref="UniProtKB/Swiss-Prot:O32068" /translation="MRLDKLLANSGYGSRKEVKAVVKAGAVMIDGKPAKDVKEHVDPD TQEVTVYGEPVDYREFIYLMMNKPQGVLSATEDSRQQTVVDLLTPEEMRFEPFPAGRL DKDTEGFLLLTNDGQLAHRLLSPKKHVPKTYEVHLKSQISREDISDLETGVYIEGGYK TKPAKAEIKTNDSGNTVIYLTITEGKYHQVKQMAKAVGNEVVYLKRLSMGRVSLDPAL APGEYRELTEEELHLLNEPQA*" /label="rsuA CDS" gene complement(2697067..2697786) /gene="rsuA" /locus_tag="BSU_30035" /old_locus_tag="BSU30035" /label="rsuA gene" downshifts complement(2697081) /Source="Nicolas_upshifts" /id="D1550" /incds=0 /nref=1 /ntot=49 /MaxReadThrough="0.79865" /MaxDrop="2.6873" /score="21.6808891" /energy="-13.5" /TU="NA" /idTUdmin="U2335" /TUdmin=154 /isTUend="FALSE" /label="downshifts" downshifts complement(2697852) /Source="Nicolas_upshifts" /id="D1551" /incds=0 /nref=1 /ntot=76 /MaxReadThrough="4.50848" /MaxDrop="2.99899" /score="8.79816042" /energy="-9.5" /TU="U2335" /idTUdmin="U2335" /TUdmin="-617" /isTUend="FALSE" /label="downshifts" CDS complement(2697855..2699489) /gene="murJ" /locus_tag="BSU_30050" /old_locus_tag="BSU30050" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11254558, 15044829, 15849754, 16850406, 19648239, 25918422, 27537185" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11254558, 15044829, 15849754, 16850406, 19648239, 25918422, 27537185; Product type t: transporter" /codon_start=1 /transl_table=11 /product="lipid II flippase" /protein_id="NP_390883.1" /db_xref="EnsemblGenomes-Gn:BSU30050" /db_xref="EnsemblGenomes-Tr:CAB14983" /db_xref="GOA:O34674" /db_xref="InterPro:IPR002797" /db_xref="InterPro:IPR024923" /db_xref="InterPro:IPR029303" /db_xref="SubtiList:BG13856" /db_xref="UniProtKB/Swiss-Prot:O34674" /translation="MSSKLLRGTFVLTLGTYISRILGMVYLIPFSIMVGATGGALFQY GYNQYTLFLNIATMGFPAAVSKFVSKYNSKGDYETSRKMLKAGMSVMLVTGMIAFFIL YLSAPMFAEISLGGKDNNGLTIDHVVYVIRMVSLALLVVPIMSLVRGFFQGHQMMGPT AVSQVVEQIVRIIFLLSATFLILKVFNGGLVIAVGYATFAALIGAFGGLVVLYIYWNK RKGSLLAMMPNTGPTANLSYKKMFFELFSYAAPYVFVGLAIPLYNYIDTNTFNKAMIE AGHQAISQDMLAILTLYVQKLVMIPVSLATAFGLTLIPTITESFTSGNYKLLNQQINQ TMQTILFLIIPAVVGISLLSGPTYTFFYGSESLHPELGANILLWYSPVAILFSLFTVN AAILQGINKQKFAVVSLVIGVVIKLVLNVPLIKLMQADGAILATALGYIASLLYGFIM IKRHAGYSYKILVKRTVLMLVLSAIMGIAVKIVQWVLGFFISYQDGQMQAAIVVVIAA AVGGAVYLYCGYRLGFLQKILGRRLPGFFRKGRHAG*" /label="murJ CDS" gene complement(2697855..2699489) /gene="murJ" /locus_tag="BSU_30050" /old_locus_tag="BSU30050" /label="murJ gene" misc_feature complement(2699521..2699540) /Source="Nicolas_upshift_promotors" /id="U2335" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.631368631368631" /psig="0.999000999001" /xcortree=2597 /SigmaFactorBS="gcggacatgaatgttcacaggattgcttttgtatttattacc gtctaaatgcccagtTGTGGTAAAATAGAAAAGTTgaatcttcgtagaaaatggtgat g" /listShort="ytgP, ytzG" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2699537) /Source="Nicolas_upshifts" /id="U2335" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.631368631368631" /psig="0.999000999001" /xcortree=2597 /SigmaFactorBS="gcggacatgaatgttcacaggattgcttttgtatttattacc gtctaaatgcccagtTGTGGTAAAATAGAAAAGTTgaatcttcgtagaaaatggtgat g" /listShort="ytgP, ytzG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2699607..2699611 /Source="Nicolas_upshift_promotors" /id="U2336" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=2734 /SigmaFactorBS="cattcatgtccgcggcaaaagaCGTTTaaggagcggctttct TTCGCTATAATAGTACTGCGgacgggtgtccgcacacgaaatgaaaagaaagttgatg a" /listShort="ytfP, S1152, S1153, opuD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2699627..2699646 /Source="Nicolas_upshift_promotors" /id="U2336" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=2734 /SigmaFactorBS="cattcatgtccgcggcaaaagaCGTTTaaggagcggctttct TTCGCTATAATAGTACTGCGgacgggtgtccgcacacgaaatgaaaagaaagttgatg a" /listShort="ytfP, S1152, S1153, opuD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2699645 /Source="Nicolas_upshifts" /id="U2336" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=2734 /SigmaFactorBS="cattcatgtccgcggcaaaagaCGTTTaaggagcggctttct TTCGCTATAATAGTACTGCGgacgggtgtccgcacacgaaatgaaaagaaagttgatg a" /listShort="ytfP, S1152, S1153, opuD" /GFF_Attribute="listLong" /label="upshifts" CDS 2699691..2700953 /gene="ytfP" /locus_tag="BSU_30060" /old_locus_tag="BSU30060" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD(FAD)-utilizing dehydrogenase" /protein_id="NP_390884.2" /db_xref="EnsemblGenomes-Gn:BSU30060" /db_xref="EnsemblGenomes-Tr:CAB14984" /db_xref="InterPro:IPR004792" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG13850" /db_xref="UniProtKB/Swiss-Prot:Q795R8" /translation="MKQYDVIVIGGGPSGLMAAIAAGEQGAGVLLIDKGNKLGRKLAI SGGGRCNVTNRLPVEEIIKHIPGNGRFLYSAFSEFNNEDIIKFFENLGIQLKEEDHGR MFPVTDKAQSVVDALLNRLKQLRVTIRTNEKIKSVLYEDGQAAGIVTNNGEMIHSQAV IIAVGGKSVPHTGSTGDGYEWAEAAGHTITELFPTEVPVTSGEPFIKQKTLQGLSLRD VAVSVLNKKGKPIITHKMDMLFTHFGLSGPAILRCSQFVVKELKKQPQVPIRIDLYPD INEETLFQKMYKELKEAPKKTIKNVLKPWMQERYLLFLLEKNGISPNVSFSELPKDPF RQFVRDCKQFTVLANGTLSLDKAFVTGGGVSVKEIDPKKMASKKMEGLYFCGEILDIH GYTGGYNITSALVTGRLAGLNAGQYARS*" /label="ytfP CDS" gene 2699691..2700953 /gene="ytfP" /locus_tag="BSU_30060" /old_locus_tag="BSU30060" /label="ytfP gene" S_feature 2700954..2701052 /Source="Nicolas_S_feature" /locus_tag="new_3076630_3076728" /HighExp="LBGstat, Lbstat, M0t90, T2.30H, T1.0H, T0.30H, BC, T2.0H, T1.30H, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1152" promotor_-35 2701026..2701032 /Source="Nicolas_upshift_promotors" /id="U2337" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=147 /SigmaFactorBS="aacattccccgcattcatgttagggtgagactTGTTTTGttt cacctgattgcgGGGTAATTTTAAGAGAGGAatgagctgccatcgtacgaccatacta a" /listShort="S1153, opuD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2701048..2701066 /Source="Nicolas_upshift_promotors" /id="U2337" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=147 /SigmaFactorBS="aacattccccgcattcatgttagggtgagactTGTTTTGttt cacctgattgcgGGGTAATTTTAAGAGAGGAatgagctgccatcgtacgaccatacta a" /listShort="S1153, opuD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2701054..2701141 /Source="Nicolas_S_feature" /locus_tag="new_3076730_3076817" /HighExp="Etha, LBGstat, Salt, M9-stat, Lbstat, LBGtran, Sw, C30, Gly, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="0.996, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1153" upshifts 2701054 /Source="Nicolas_upshifts" /id="U2337" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=147 /SigmaFactorBS="aacattccccgcattcatgttagggtgagactTGTTTTGttt cacctgattgcgGGGTAATTTTAAGAGAGGAatgagctgccatcgtacgaccatacta a" /listShort="S1153, opuD" /GFF_Attribute="listLong" /label="upshifts" CDS 2701142..2702680 /gene="opuD" /locus_tag="BSU_30070" /old_locus_tag="BSU30070" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:14996799, 15849754, 16850406, 8752321, 9925583" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14996799, 15849754, 16850406, 8752321, 9925583; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glycine betaine transporter" /protein_id="NP_390885.1" /db_xref="EnsemblGenomes-Gn:BSU30070" /db_xref="EnsemblGenomes-Tr:CAB14985" /db_xref="GOA:P54417" /db_xref="InterPro:IPR000060" /db_xref="InterPro:IPR018093" /db_xref="SubtiList:BG11958" /db_xref="UniProtKB/Swiss-Prot:P54417" /translation="MLKHISSVFWIVIAITAAAVLWGVISPDSLQNVSQSAQAFITDS FGWYYLLVVSLFVGFCLFLIFSPIGKIKLGKPDEKPEFGLLSWFAMLFSAGMGIGLVF YGAAEPISHYAISSPSGETETPQAFRDALRYTFFHWGLHAWAIYAIVALCIAYFQFRK GAPGLISSTLSPILGDKVNGPIGKAIDCIAVFATVVGVSTSLGLGATQINGGLNYLFG IPNAFIVQLVLIIIVTVLFLLSAWSGLGKGIKYLSNTNMVLAGLLMLFMLVVGPTVLI MNSFTDSIGQYIQNIVQMSFRLTPNDPEKREWINSWTIFYWAWWISWSPFVGIFIARV SRGRTIREFLIGVLVTPCILTFLWFSIFGVSAMDLQQKGAFNVAKLSTETMLFGTLDH YPLTMVTSILALILIAVFFITSADSATFVLGMQTSYGSLNPANSVKLSWGIIQSAMAA VLLYSGGLAALQNTAILAALPFSIVILLMIASLYQSLSKERREIKKAEKLDKPRSPRV KKAY*" /label="opuD CDS" gene 2701142..2702680 /gene="opuD" /locus_tag="BSU_30070" /old_locus_tag="BSU30070" /label="opuD gene" downshifts 2702660 /Source="Nicolas_upshifts" /id="D1552" /incds=0 /nref=231 /ntot=263 /MaxReadThrough="2.0688" /MaxDrop="6.06429" /score="27.1497809" /energy="-16.3" /TU="NA" /idTUdmin="U2336" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2702717..2702899) /gene="yteV" /locus_tag="BSU_30080" /old_locus_tag="BSU30080" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 8990290" /codon_start=1 /transl_table=11 /product="conserved sporulation-related protein" /protein_id="NP_390886.1" /db_xref="EnsemblGenomes-Gn:BSU30080" /db_xref="EnsemblGenomes-Tr:CAB14986" /db_xref="GOA:P94496" /db_xref="InterPro:IPR020296" /db_xref="SubtiList:BG12339" /db_xref="UniProtKB/Swiss-Prot:P94496" /translation="MLKVAVFDEEHEKDLQTEINSFLKGISEEQLIDIKYTVSAACDP DGEQLYCFSALILYRK*" /label="yteV CDS" gene complement(2702717..2702899) /gene="yteV" /locus_tag="BSU_30080" /old_locus_tag="BSU30080" /label="yteV gene" downshifts complement(2702736) /Source="Nicolas_upshifts" /id="D1553" /incds=0 /nref=10 /ntot=61 /MaxReadThrough="0.597819999999999" /MaxDrop="4.78152" /score="32.507978" /energy="-16.3" /TU="NA" /idTUdmin="U2338" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2702914..2702932) /Source="Nicolas_upshift_promotors" /id="U2338" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=963 /SigmaFactorBS="gaaagctttttatccggaaacgagataatcatcatttctctA TCATAacgctgttccaaacgGAATAGATTGATAGAGAAAggagagcggataaaatgct g" /listShort="yteV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2702934) /Source="Nicolas_upshifts" /id="U2338" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=963 /SigmaFactorBS="gaaagctttttatccggaaacgagataatcatcatttctctA TCATAacgctgttccaaacgGAATAGATTGATAGAGAAAggagagcggataaaatgct g" /listShort="yteV" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2702948..2702953) /Source="Nicolas_upshift_promotors" /id="U2338" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=963 /SigmaFactorBS="gaaagctttttatccggaaacgagataatcatcatttctctA TCATAacgctgttccaaacgGAATAGATTGATAGAGAAAggagagcggataaaatgct g" /listShort="yteV" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2702967..2703635) /gene="rmgU" /locus_tag="BSU_30090" /old_locus_tag="BSU30090" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 17449691, 23504016; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane enzyme for rhamnogalaturonan degradation" /protein_id="NP_390887.1" /db_xref="EnsemblGenomes-Gn:BSU30090" /db_xref="EnsemblGenomes-Tr:CAB14987" /db_xref="GOA:O34378" /db_xref="InterPro:IPR006938" /db_xref="SubtiList:BG13846" /db_xref="UniProtKB/Swiss-Prot:O34378" /translation="MEHDGSLGRMLRFCEWIMRFAYTNLLWLFFTLLGLGVFGIMPAT AALFAVMRKWIQGQDNVPVLKTFWQEYKGEFFRSNLLGAVLALIGVIIYIDLALIYPS HFLLHILRFAIMIFGFLFVSMLFYVFPLLVHFDWKKRLYVKFSLLLSVAYLQYTLTML ALTVALFFLLAYLPGIVPFFSVSLISYCHMRIVYAVLLKVEQHGGEPQRKSHIRKAFY PETR*" /label="rmgU CDS" gene complement(2702967..2703635) /gene="rmgU" /locus_tag="BSU_30090" /old_locus_tag="BSU30090" /label="rmgU gene" CDS complement(2703657..2704943) /gene="rmgT" /locus_tag="BSU_30100" /old_locus_tag="BSU30100" /EC_number="1.1.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17449691, 23504016; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dehydrogenase of rhamnogalaturonan degradation" /protein_id="NP_390888.1" /db_xref="EnsemblGenomes-Gn:BSU30100" /db_xref="EnsemblGenomes-Tr:CAB14988" /db_xref="GOA:O34371" /db_xref="InterPro:IPR000683" /db_xref="InterPro:IPR004104" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13845" /db_xref="UniProtKB/Swiss-Prot:O34371" /translation="MKNIVFCGLSSRAFSMFIKPLMERFSTHYEITGLLDADPKRFAV CKKKFPELAHVPEFSEDAFDEMMRVSKPDIVIVAGRDDTHVAYIVKSLQWNTDVITEK PMVTTVQDANRVLEAEAKSEGKVTVAFNYRYSPFHRKIKEMILDGKIGRVTSVDLNWY IDTYHGASYFKRWNRSRQFSGGLSVHKSTHHFDLVNWWLGQNPEEVFAYGALNYYGPD SEWNPLPEEDGRFCGTCRVKEKCHYYSRWHPRSSKASIKDDHLEAGDQSSLYTAYRPD ACIFDEEIDIEDTYVAAVKYDGGALLSYSIIFSAPYEGYRLTINGTKGRIESNEFHEP SRIPFAFPEQTIEYYPLFESKQTIQVVKNEGGHGGGDPLLLEDLFLGKDPLRRYDILA GAEAGAYSIAVGEGMWRSVAEKKPIGMKELFQMQNV*" /label="rmgT CDS" gene complement(2703657..2704943) /gene="rmgT" /locus_tag="BSU_30100" /old_locus_tag="BSU30100" /label="rmgT gene" CDS complement(2704955..2705458) /gene="rmgS" /locus_tag="BSU_30110" /old_locus_tag="BSU30110" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17449691, 23504016" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17449691, 23504016; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="lipoprotein required for rhamnogalaturonan transport and degradation" /protein_id="NP_390889.2" /db_xref="EnsemblGenomes-Gn:BSU30110" /db_xref="EnsemblGenomes-Tr:CAB14989" /db_xref="GOA:C0SP80" /db_xref="SubtiList:BG13844" /db_xref="UniProtKB/Swiss-Prot:C0SP80" /translation="MTKRIRTALCVIVSVLFLASCSSRPDGMHVILFSDMQAGVQEKI KKAAEQNAGKVDIFPAFQEKLLTEITAHEGDVFIVPEDMFQAYDDPENFQPLNGLPPE KTSPYTTVNKKTGEKTIYAVQIEKGKKQLNGYSFQLNRDMAAFIPVYAEKTEEALQLI SQLTEAR*" /label="rmgS CDS" gene complement(2704955..2705458) /gene="rmgS" /locus_tag="BSU_30110" /old_locus_tag="BSU30110" /label="rmgS gene" CDS complement(2705455..2706576) /gene="rmgQ" /locus_tag="BSU_30120" /old_locus_tag="BSU30120" /EC_number="3.2.1.172" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15148314, 15906318, 16781735, 16870154, 17449691, 23504016" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15148314, 15906318, 16781735, 16870154, 17449691, 23504016; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="unsaturated rhamnogalacturonyl hydrolase" /protein_id="NP_390890.3" /db_xref="EnsemblGenomes-Gn:BSU30120" /db_xref="EnsemblGenomes-Tr:CAB14990" /db_xref="GOA:O34559" /db_xref="InterPro:IPR008928" /db_xref="InterPro:IPR010905" /db_xref="PDB:1NC5" /db_xref="PDB:2D8L" /db_xref="PDB:2GH4" /db_xref="SubtiList:BG13843" /db_xref="UniProtKB/Swiss-Prot:O34559" /translation="MGSMDQSIAVKSPLTYAEALANTIMNTYTVEELPPANRWHYHQG VFLCGVLRLWEATGEKRYFEYAKAYADLLIDDNGNLLFRRDELDAIQAGLILFPLYEQ TKDERYVKAAKRLRSLYGTLNRTSEGGFWHKDGYPYQMWLDGLYMGGPFALKYANLKQ ETELFDQVVLQESLMRKHTKDAKTGLFYHAWDEAKKMPWANEETGCSPEFWARSIGWY VMSLADMIEELPKKHPNRHVWKNTLQDMIKSICRYQDKETGLWYQIVDKGDRSDNWLE SSGSCLYMYAIAKGINKGYLDRAYETTLLKAYQGLIQHKTETSEDGAFLVKDICVGTS AGFYDYYVSRERSTNDLHGAGAFILAMTELEPLFRSAGK*" /label="rmgQ CDS" gene complement(2705455..2706576) /gene="rmgQ" /locus_tag="BSU_30120" /old_locus_tag="BSU30120" /label="rmgQ gene" CDS complement(2706584..2707549) /gene="rmgP" /locus_tag="BSU_30135" /old_locus_tag="BSU30135" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 17449691, 23504016" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 17449691, 23504016; Product type t: transporter" /codon_start=1 /transl_table=11 /product="permease for unsaturated rhamnogalacturonan" /protein_id="NP_390892.2" /db_xref="EnsemblGenomes-Gn:BSU30135" /db_xref="EnsemblGenomes-Tr:CAB14992" /db_xref="GOA:C0SPB3" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG13841" /db_xref="UniProtKB/Swiss-Prot:C0SPB3" /translation="MKTAEAQAPAVDAVIFKKEKRKRLLIKLIQQKYLYLMILPGCIY FLLFKYVPMWGIVIAFQDYQPFLGILGSEWVGLKHFIRLFTEPTFFLLLKNTLVLFAL NLAIFFPVPILLALLLNEVRIALFKKFVQTLIYIPHFMSWVIVVSLSFVLLTVDGGLI NELIVFFGGEKINFLLNEEWFRPLYILQVIWREAGWSTIIYLAAITAVDPQLYEAAKM DGAGRLRQMWHITLPAIKSVIVVLLILKIGDTLELGFEHVYLLLNATNREVAEIFDTY VYTAGLKQGQFSYSTAVGVFKAAVGLILVMLANRLAKKFGEEGIY*" /label="rmgP CDS" gene complement(2706584..2707549) /gene="rmgP" /locus_tag="BSU_30135" /old_locus_tag="BSU30135" /label="rmgP gene" upshifts complement(2707575) /Source="Nicolas_upshifts" /id="U2339" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.75924075924076" /psig="0.918081918081918" /xcortree=341 /SigmaFactorBS="caggatgtgatcatatgaTTGTAGACggacttttgcctgcTG CGCTACAGTGAATGCAAGaatccgtgaaaggaggctaggaaaaaatgaaaacagcaga a" /listShort="yteP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2707576..2707595) /Source="Nicolas_upshift_promotors" /id="U2339" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.75924075924076" /psig="0.918081918081918" /xcortree=341 /SigmaFactorBS="caggatgtgatcatatgaTTGTAGACggacttttgcctgcTG CGCTACAGTGAATGCAAGaatccgtgaaaggaggctaggaaaaaatgaaaacagcaga a" /listShort="yteP" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2707610..2707617) /Source="Nicolas_upshift_promotors" /id="U2339" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.75924075924076" /psig="0.918081918081918" /xcortree=341 /SigmaFactorBS="caggatgtgatcatatgaTTGTAGACggacttttgcctgcTG CGCTACAGTGAATGCAAGaatccgtgaaaggaggctaggaaaaaatgaaaacagcaga a" /listShort="yteP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2707705..2707712 /Source="Nicolas_upshift_promotors" /id="U2340" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.965034965034965" /psig="0.998001998001998" /xcortree=561 /SigmaFactorBS="cggtccacctgaaaaaaagacaccgatattagaaaatgatTA TTGACAatatctatcaatcttTGGATTAATTGTATTAAGGTgaagtggatgttatgaa a" /listShort="ytdP" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2707725 /Source="Nicolas_upshifts" /id="U2340" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.965034965034965" /psig="0.998001998001998" /xcortree=561 /SigmaFactorBS="cggtccacctgaaaaaaagacaccgatattagaaaatgatTA TTGACAatatctatcaatcttTGGATTAATTGTATTAAGGTgaagtggatgttatgaa a" /listShort="ytdP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2707728..2707747 /Source="Nicolas_upshift_promotors" /id="U2340" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.965034965034965" /psig="0.998001998001998" /xcortree=561 /SigmaFactorBS="cggtccacctgaaaaaaagacaccgatattagaaaatgatTA TTGACAatatctatcaatcttTGGATTAATTGTATTAAGGTgaagtggatgttatgaa a" /listShort="ytdP" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2707765..2710083 /gene="rmgR" /locus_tag="BSU_30150" /old_locus_tag="BSU30150" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 23504016; Product type r: regulator" /codon_start=1 /transl_table=11 /product="membrane bound transcriptional regulator (controlling rhamnogalacturonan degradation)" /protein_id="NP_390893.1" /db_xref="EnsemblGenomes-Gn:BSU30150" /db_xref="EnsemblGenomes-Tr:CAB14993" /db_xref="GOA:O32071" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR018060" /db_xref="SubtiList:BG13838" /db_xref="UniProtKB/Swiss-Prot:O32071" /translation="MGGFMKRSQYKFYYKLITFFCLLSTIPVILVGLFSYEHSQKTAI SNVSEEKFDTLQQTQQSIEHILKTVDHSLTHYVSSPPLLRTLSEPLHSDQFQIYNQVN QELNYLQSFDTDLSNMTLVSYTKKWYMNNSGLYRLNTDTLHEAASAYTKQKASRSYWT LEENNHLISTKEGTAENCRYNINLIKQLPLNSTNTKGLAAASIPSCSLVKNMPGYSNA NNLFIIDEKGLIILHNNMSDVGESLHNDGFVQKVLAQTANSGQFETVIDRIHYKVTYQ KSDYNAWTYFSLVSLPELKKEAKSIGWITFAVCLILLTLSLLFSWLGSRHFYKPIRVL YESFARHGAIQEKQQPPQNEFELIEQSFKQLKDRNDDLEETMKQQATHLQQYFMVRLM LGKLTDEEVDNRFESLGLKQNWRHLALLVLQIDTLNHTPYEKKDMDLLLFAVNSLIER NIPTDKHLAPAVVDKQQATILINQSGTKEEFMAELNETARMIQEKAEAELQLSVSIGI SQPFDVLTKAKTAYAEGSEALKYRLKAENKSIIFYEDLDQKKTFKTHFPKQLQHELFD AVKAGDKEKADKCLHAILQAIFTQNTNPYQFQIAIARFLNHVIELMHVLGIELFELEE NKMLYDQIFELKTFEDTENWLKNEFIDPMTDKVNARADAQYKNISDNIIHIIHHEFES ELTLDEIARRLHYNPNYLSSIFKKEMGISFSEYVSSYRHHMAKSWLAETDMAVKDIAE KLKYKNSQNFIRSFKKLEGITPGNYRQQKRSM*" /label="rmgR CDS" gene 2707765..2710083 /gene="rmgR" /locus_tag="BSU_30150" /old_locus_tag="BSU30150" /label="rmgR gene" downshifts 2710073 /Source="Nicolas_upshifts" /id="D1554" /incds=0 /nref=8 /ntot=42 /MaxReadThrough="1.43431" /MaxDrop="3.6268" /score="-7.37324741" /energy="-10.2" /TU="NA" /idTUdmin="U2340" /TUdmin=1870 /isTUend="FALSE" /label="downshifts" CDS complement(2710124..2711620) /gene="ytcQ" /locus_tag="BSU_30160" /old_locus_tag="BSU30160" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative ABC transporter (binding lipoprotein)" /protein_id="NP_390894.3" /db_xref="EnsemblGenomes-Gn:BSU30160" /db_xref="EnsemblGenomes-Tr:CAB14994" /db_xref="GOA:Q795R2" /db_xref="SubtiList:BG13836" /db_xref="UniProtKB/Swiss-Prot:Q795R2" /translation="MGNKWRVLLIVLVLALGGVLAGCKGTDQSSAEGKAGPDSKVKLS WMAILYHQQPPKDRAIKEIEKLTNTELDITWVPDAVKEDRLNAALAAGNLPQIVTIQD IKNSSVMNAFRSGMFWEIGDYIKDYPNLNKMNKLINKNVTIDGKLYGIYRERPLSRQG IVIRKDWLDNLNLKTPKTLDELYEVAKAFTEDDPDKDGKDDTFGLADRNDLIYGAFKT IGSYEGMPTDWKESGGKFTPDFMTQEYKDTMNYMKKLRDNGYMNKDFPVTSKTQQQEL FSQGKAGIYIGNMVDAVNLRDHASDKSMKLEIINRIKGPDGKERVWASGGHNGVFAFP KTSVKTEAELKRILAFFDRIAEEDVYSLMTYGIDGVHYNKGEDKTFTRKESQVKDWQT DIQPLSALIAIDKAYLKNTGDPLRTAYEELTEDNEKIIVSNPAESLYSASESERGDEL KKIIDDATYKYMIGDITESQFDKEVEKWESSGGKQIIQEYEEAFKQAK*" /label="ytcQ CDS" gene complement(2710124..2711620) /gene="ytcQ" /locus_tag="BSU_30160" /old_locus_tag="BSU30160" /label="ytcQ gene" downshifts complement(2710126) /Source="Nicolas_upshifts" /id="D1555" /incds=0 /nref=26 /ntot=160 /MaxReadThrough="-0.0485899999999999" /MaxDrop="5.21039" /score="6.31011081" /energy="-11.2" /TU="NA" /idTUdmin="U2341" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(2711645..2712505) /gene="ytcP" /locus_tag="BSU_30170" /old_locus_tag="BSU30170" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (permease)" /protein_id="NP_390895.1" /db_xref="EnsemblGenomes-Gn:BSU30170" /db_xref="EnsemblGenomes-Tr:CAB14995" /db_xref="GOA:P53561" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11788" /db_xref="UniProtKB/Swiss-Prot:P53561" /translation="MKNRLFDMLIYGFLLMFALICVLPFIHVIAASFATVEEVVSKKF ILIPTTFSLDAYRYIFSTDIIYKSLLVSVFVTVIGTAVSMFLSSLMAYGLSRRDLIGR QPLMFLVVFTMLFSGGMIPTFLVVKSLGLLDSYWALILPTAINAFNLIILKNFFQNIP SSLEESAKIDGCNDLGIFFKIVLPLSLPAIATISLFYAVTYWNTYMTAILYLNDSAKW PIQVLLRQIVIVSSGMQGDMSEMGSGSPPPEQTIKMAVIVVATIPVLLVYPFIQKHFA KGALLGSVKG*" /label="ytcP CDS" gene complement(2711645..2712505) /gene="ytcP" /locus_tag="BSU_30170" /old_locus_tag="BSU30170" /label="ytcP gene" promotor_-10 complement(2712581..2712600) /Source="Nicolas_upshift_promotors" /id="U2341" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.72927072927073" /psig="0.998001998001998" /xcortree=353 /SigmaFactorBS="cccggccggggacactgttcaaatgatTATAGACAtggcaat cacagattTGCTACATTTTAGACACGATatcgtcacatgctgagctcggtttccaaaa a" /listShort="ytcP, ytcQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2712590) /Source="Nicolas_upshifts" /id="U2341" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.72927072927073" /psig="0.998001998001998" /xcortree=353 /SigmaFactorBS="cccggccggggacactgttcaaatgatTATAGACAtggcaat cacagattTGCTACATTTTAGACACGATatcgtcacatgctgagctcggtttccaaaa a" /listShort="ytcP, ytcQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2712616..2712623) /Source="Nicolas_upshift_promotors" /id="U2341" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.72927072927073" /psig="0.998001998001998" /xcortree=353 /SigmaFactorBS="cccggccggggacactgttcaaatgatTATAGACAtggcaat cacagattTGCTACATTTTAGACACGATatcgtcacatgctgagctcggtttccaaaa a" /listShort="ytcP, ytcQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2712712..2713473) /gene="ytbQ" /locus_tag="BSU_30180" /old_locus_tag="BSU30180" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD-dependent nucleoside-diphosphate-sugar epimerase" /protein_id="NP_390896.2" /db_xref="EnsemblGenomes-Gn:BSU30180" /db_xref="EnsemblGenomes-Tr:CAB14996" /db_xref="GOA:P53560" /db_xref="InterPro:IPR001509" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11787" /db_xref="UniProtKB/Swiss-Prot:P53560" /translation="MKKVLIAGGNGVIGRLLAEGLISDYEVTVLDKDHFDGKASSIQA DAANYEELLKKIPKDTDAILNLLAVKIKYDIMDIAEFEKMTDVFYRASYYLCRAAAEL GIQKLVFASSNHVTDVYEKDGRSLLGREITTSDYPLSKNLYGVLKLTSEQIGHLFYLE NKLSVINLRIGTVVTDEMDTLHEKERTKKTLLSHPDLLSIFKAAIETNIRYGTYYAVS DNPGRPWSIESAVNELGFSPQINTAELLNEEENGA*" /label="ytbQ CDS" gene complement(2712712..2713473) /gene="ytbQ" /locus_tag="BSU_30180" /old_locus_tag="BSU30180" /label="ytbQ gene" downshifts complement(2712741) /Source="Nicolas_upshifts" /id="D1556" /incds=0 /nref=153 /ntot=196 /MaxReadThrough="1.18543" /MaxDrop="5.85654" /score="12.3836957" /energy="-11.1" /TU="NA" /idTUdmin="U2344" /TUdmin="-19" /isTUend="TRUE" /label="downshifts" S_feature complement(2713474..2713549) /Source="Nicolas_S_feature" /locus_tag="new_3089150_3089225_c" /HighExp="LPh, HPh, aero, Gly, HiOs, BMM, GM-0.1, GM 10, GM 15, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1154" CDS complement(2713550..2714737) /gene="bioI" /locus_tag="BSU_30190" /old_locus_tag="BSU30190" /EC_number="1.14.14.46" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11368323, 11472016, 12943422, 20658980, 21435937, 21437340, 28196402" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11368323, 11472016, 12943422, 20658980, 21435937, 21437340, 28196402; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome P450 for pimelic acid formation for biotin biosynthesis" /protein_id="NP_390897.1" /db_xref="EnsemblGenomes-Gn:BSU30190" /db_xref="EnsemblGenomes-Tr:CAB14997" /db_xref="GOA:P53554" /db_xref="InterPro:IPR001128" /db_xref="InterPro:IPR002397" /db_xref="InterPro:IPR017972" /db_xref="InterPro:IPR036396" /db_xref="PDB:3EJB" /db_xref="PDB:3EJD" /db_xref="PDB:3EJE" /db_xref="SubtiList:BG11528" /db_xref="UniProtKB/Swiss-Prot:P53554" /translation="MTIASSTASSEFLKNPYSFYDTLRAVHPIYKGSFLKYPGWYVTG YEETAAILKDARFKVRTPLPESSTKYQDLSHVQNQMMLFQNQPDHRRLRTLASGAFTP RTTESYQPYIIETVHHLLDQVQGKKKMEVISDFAFPLASFVIANIIGVPEEDREQLKE WAASLIQTIDFTRSRKALTEGNIMAVQAMAYFKELIQKRKRHPQQDMISMLLKGREKD KLTEEEAASTCILLAIAGHETTVNLISNSVLCLLQHPEQLLKLRENPDLIGTAVEECL RYESPTQMTARVASEDIDICGVTIRQGEQVYLLLGAANRDPSIFTNPDVFDITRSPNP HLSFGHGHHVCLGSSLARLEAQIAINTLLQRMPSLNLADFEWRYRPLFGFRALEELPV TFE*" /label="bioI CDS" gene complement(2713550..2714737) /gene="bioI" /locus_tag="BSU_30190" /old_locus_tag="BSU30190" /label="bioI gene" CDS complement(2714806..2715813) /gene="bioB" /locus_tag="BSU_30200" /old_locus_tag="BSU30200" /EC_number="2.8.1.6" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2110099, 8763940, 11717296, 12368242" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2110099, 8763940, 11717296, 12368242; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="biotin synthase" /protein_id="NP_390898.1" /db_xref="EnsemblGenomes-Gn:BSU30200" /db_xref="EnsemblGenomes-Tr:CAB14998" /db_xref="GOA:P53557" /db_xref="InterPro:IPR002684" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR010722" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR024177" /db_xref="SubtiList:BG11525" /db_xref="UniProtKB/Swiss-Prot:P53557" /translation="MNQWMELADRVLAGAEVTDEEALSILHCPDEDILLLMHGAFHIR KHFYGKKVKLNMIMNAKSGLCPENCGYCSQSAISKAPIESYRMVNKETLLEGAKRAHD LNIGTYCIVASGRGPSNREVDQVVDAVQEIKETYGLKICACLGLLKPEQAKRLKDAGV DRYNHNLNTSQRNHSNITTSHTYDDRVNTVEIAKESGLSPCSGAIIGMKETKQDVIDI AKSLKALDADSIPVNFLHAIDGTPLEGVNELNPLYCLKVLALFRFINPSKEIRISGGR EVNLRTLQPLGLYAANSIFVGDYLTTAGQEETEDHKMLSDLGFEVESVEEMKASLSAK S*" /label="bioB CDS" gene complement(2714806..2715813) /gene="bioB" /locus_tag="BSU_30200" /old_locus_tag="BSU30200" /label="bioB gene" CDS complement(2715816..2716511) /gene="bioD" /locus_tag="BSU_30210" /old_locus_tag="BSU30210" /EC_number="6.3.3.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2110099, 8763940, 11717296, 12368242, 20565114" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2110099, 8763940, 11717296, 12368242, 20565114; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dethiobiotin synthetase" /protein_id="NP_390899.1" /db_xref="EnsemblGenomes-Gn:BSU30210" /db_xref="EnsemblGenomes-Tr:CAB14999" /db_xref="GOA:P53558" /db_xref="InterPro:IPR004472" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11526" /db_xref="UniProtKB/Swiss-Prot:P53558" /translation="MRGFFVTGTDTEVGKTVISSGLAALLKDNNRHVGVYKPFLSGIS RHHPDSDTSLLKDMSQTSLSHEDITPFAFKAPLAPYVAGKLEGKTVTMEEVLSHWGRI REKHECFIVEGAGGISVPLGEDYLVSHVIKALQLPMIIVARPRLGTINHTFLTVKYAE SMGLPIAGIIINGISDSPDEDEKTNPEMIERLCGVPILGVTPKLANVTKETVLHMVKD HINLSLLMNQVGV*" /label="bioD CDS" gene complement(2715816..2716511) /gene="bioD" /locus_tag="BSU_30210" /old_locus_tag="BSU30210" /label="bioD gene" CDS complement(2716508..2717677) /gene="bioFC" /locus_tag="BSU_30220" /old_locus_tag="BSU30220" /EC_number="2.3.1.-" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8763940, 11322938, 11717296, 12368242, 15056910, 16557306" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8763940, 11322938, 11717296, 12368242, 15056910, 16557306; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="8-amino-7-oxononanoate synthase (pimeloyl-CoA-dependent)" /protein_id="NP_390900.1" /db_xref="EnsemblGenomes-Gn:BSU30220" /db_xref="EnsemblGenomes-Tr:CAB15000" /db_xref="GOA:P53556" /db_xref="InterPro:IPR001917" /db_xref="InterPro:IPR004723" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG11527" /db_xref="UniProtKB/Swiss-Prot:P53556" /translation="MKIDSWLNERLDRMKEAGVHRNLRSMDGAPVPERNIDGENQTVW SSNNYLGLASDRRLIDAAQTALQQFGTGSSGSRLTTGNSVWHEKLEKKIASFKLTEAA LLFSSGYLANVGVLSSLPEKEDVILSDQLNHASMIDGCRLSKADTVVYRHIDMNDLEN KLNETQRYQRRFIVTDGVFSMDGTIAPLDQIISLAKRYHAFVVVDDAHATGVLGDSGQ GTSEYFGVCPDIVIGTLSKAVGAEGGFAAGSAVFIDFLLNHARTFIFQTAIPPASCAA AHEAFNIIEASREKRQLLFSYISMIRTSLKNMGYVVKGDHTPIIPVVIGDAHKTVLFA EKLQGKGIYAPAIRPPTVAPGESRIRITITSDHSMGDIDHLLQTFHSIGKELHII*" /label="bioFC CDS" gene complement(2716508..2717677) /gene="bioFC" /locus_tag="BSU_30220" /old_locus_tag="BSU30220" /label="bioFC gene" promotor_-35 2716544..2716551 /Source="Nicolas_upshift_promotors" /id="U2342" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.996003996003996" /psig="0.997002997002997" /xcortree=2064 /SigmaFactorBS="tcctttccgattgaatgaaaTGTTTGCAgcaaatgatcaata TCACCCATACTGTGGTCAGAcgtgattgtaattcgaatccggctttcacccggcgcaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2716566..2716585 /Source="Nicolas_upshift_promotors" /id="U2342" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.996003996003996" /psig="0.997002997002997" /xcortree=2064 /SigmaFactorBS="tcctttccgattgaatgaaaTGTTTGCAgcaaatgatcaata TCACCCATACTGTGGTCAGAcgtgattgtaattcgaatccggctttcacccggcgcaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2716584 /Source="Nicolas_upshifts" /id="U2342" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.996003996003996" /psig="0.997002997002997" /xcortree=2064 /SigmaFactorBS="tcctttccgattgaatgaaaTGTTTGCAgcaaatgatcaata TCACCCATACTGTGGTCAGAcgtgattgtaattcgaatccggctttcacccggcgcaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2717667..2719013) /gene="bioK" /locus_tag="BSU_30230" /old_locus_tag="BSU30230" /EC_number="2.6.1.105" /function="4.1: Biotin" /experiment="publication(s) with functional evidences, PMID:15880481, 20565114, 21437340" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15880481, 20565114, 21437340; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-lysine-8-amino-7-oxononanoate aminotransferase" /protein_id="NP_390901.1" /db_xref="EnsemblGenomes-Gn:BSU30230" /db_xref="EnsemblGenomes-Tr:CAB15001" /db_xref="GOA:P53555" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR005815" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="PDB:3DOD" /db_xref="PDB:3DRD" /db_xref="PDB:3DU4" /db_xref="SubtiList:BG11524" /db_xref="UniProtKB/Swiss-Prot:P53555" /translation="MTHDLIEKSKKHLWLPFTQMKDYDENPLIIESGTGIKVKDINGK EYYDGFSSVWLNVHGHRKKELDDAIKKQLGKIAHSTLLGMTNVPATQLAETLIDISPK KLTRVFYSDSGAEAMEIALKMAFQYWKNIGKPEKQKFIAMKNGYHGDTIGAVSVGSIE LFHHVYGPLMFESYKAPIPYVYRSESGDPDECRDQCLRELAQLLEEHHEEIAALSIES MVQGASGMIVMPEGYLAGVRELCTTYDVLMIVDEVATGFGRTGKMFACEHENVQPDLM AAGKGITGGYLPIAVTFATEDIYKAFYDDYENLKTFFHGHSYTGNQLGCAVALENLAL FESENIVEQVAEKSKKLHFLLQDLHALPHVGDIRQLGFMCGAELVRSKETKEPYPADR RIGYKVSLKMRELGMLTRPLGDVIAFLPPLASTAEELSEMVAIMKQAIHEVTSLED*" /label="bioK CDS" gene complement(2717667..2719013) /gene="bioK" /locus_tag="BSU_30230" /old_locus_tag="BSU30230" /label="bioK gene" promotor_-35 2718083..2718087 /Source="Nicolas_upshift_promotors" /id="U2343" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1183 /SigmaFactorBS="gccaagctgattgcctgtataggaatggccatggaaaaaggT TTTTaggttttcataatcaTCATAGAATGCCTTATAGAtgtcttcagtggcaaacgta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2718102 /Source="Nicolas_upshifts" /id="U2343" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1183 /SigmaFactorBS="gccaagctgattgcctgtataggaatggccatggaaaaaggT TTTTaggttttcataatcaTCATAGAATGCCTTATAGAtgtcttcagtggcaaacgta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2718103..2718121 /Source="Nicolas_upshift_promotors" /id="U2343" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1183 /SigmaFactorBS="gccaagctgattgcctgtataggaatggccatggaaaaaggT TTTTaggttttcataatcaTCATAGAATGCCTTATAGAtgtcttcagtggcaaacgta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2719003..2719779) /gene="bioW" /locus_tag="BSU_30240" /old_locus_tag="BSU30240" /EC_number="6.2.1.14" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8763940, 11368323, 11717296, 21437340, 28196402, 29054876" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8763940, 11368323, 11717296, 21437340, 28196402, 29054876; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="6-carboxyhexanoate-CoA ligase (pimeloyl-CoA synthase)" /protein_id="NP_390902.3" /db_xref="EnsemblGenomes-Gn:BSU30240" /db_xref="EnsemblGenomes-Tr:CAB15002" /db_xref="GOA:P53559" /db_xref="InterPro:IPR005499" /db_xref="PDB:5FLG" /db_xref="PDB:5FLL" /db_xref="PDB:5FM0" /db_xref="PDB:5G1F" /db_xref="SubtiList:BG11529" /db_xref="UniProtKB/Swiss-Prot:P53559" /translation="MQEETFYSVRMRASMNGSHEDGGKHISGGERLIPFHEMKHTVNA LLEKGLSHSRGKPDFMQIQFEEVHESIKTIQPLPVHTNEVSCPEEGQKLARLLLEKEG VSRDVIEKAYEQIPEWSDVRGAVLFDIHTGKRMDQTKEKGVRVSRMDWPDANFEKWAL HSHVPAHSRIKEALALASKVSRHPAVVAELCWSDDPDYITGYVAGKKMGYQRITAMKE YGTEEGCRVFFIDGSNDVNTYIHDLEKQPILIEWEEDHDS*" /label="bioW CDS" gene complement(2719003..2719779) /gene="bioW" /locus_tag="BSU_30240" /old_locus_tag="BSU30240" /label="bioW gene" S_feature complement(2719780..2719872) /Source="Nicolas_S_feature" /locus_tag="new_3095456_3095548_c" /HighExp="T-5.40H, GM 60, LPh, GM 25, HPh, MG 120, M9-exp, BMM, GM 5, MG 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1155" promotor_-10 complement(2719858..2719877) /Source="Nicolas_upshift_promotors" /id="U2344" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2918 /SigmaFactorBS="tttaaccaactgccataaatcgatcctttcttcTATTGACAg aaacaggagagaaTAATATATTCTAATTGTTAAcctttgaatataattggttaacaat t" /listShort="S1155, bioW, bioK, bioF, bioD, bioB, bioI, S1154, ytbQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2719872) /Source="Nicolas_upshifts" /id="U2344" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2918 /SigmaFactorBS="tttaaccaactgccataaatcgatcctttcttcTATTGACAg aaacaggagagaaTAATATATTCTAATTGTTAAcctttgaatataattggttaacaat t" /listShort="S1155, bioW, bioK, bioF, bioD, bioB, bioI, S1154, ytbQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2719892..2719899) /Source="Nicolas_upshift_promotors" /id="U2344" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2918 /SigmaFactorBS="tttaaccaactgccataaatcgatcctttcttcTATTGACAg aaacaggagagaaTAATATATTCTAATTGTTAAcctttgaatataattggttaacaat t" /listShort="S1155, bioW, bioK, bioF, bioD, bioB, bioI, S1154, ytbQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2719989..2720888) /gene="ytaP" /locus_tag="BSU_30250" /old_locus_tag="BSU30250" /EC_number="3.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390903.1" /db_xref="EnsemblGenomes-Gn:BSU30250" /db_xref="EnsemblGenomes-Tr:CAB15003" /db_xref="GOA:O34973" /db_xref="InterPro:IPR002471" /db_xref="InterPro:IPR002925" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG11786" /db_xref="UniProtKB/Swiss-Prot:O34973" /translation="MRAERRKQLFRLLGDLPDRRPISVETLRIEEREENIVETLLLDL NGHEKAPAYFVKPKKTEGPCPAVLFQHSHGGQYDRGKSELIEGADYLKTPSFSDELTS LGYGVLAIDHWGFGDRRGKAESEIFKEMLLTGKVMWGMMIYDSLSALDYMQSRSDVQP DRIGTIGMSMGGLMAWWTAALDDRIKVCVDLCSQVDHHVLIKTQNLDRHGFYYYVPSL AKHFSASEIQSLIAPRPHLSLVGVHDRLTPAEGVDKIEKELTAVYAGQGAADCYRVVR SASGHFETAVIRHEAVRFLQKWL*" /label="ytaP CDS" gene complement(2719989..2720888) /gene="ytaP" /locus_tag="BSU_30250" /old_locus_tag="BSU30250" /label="ytaP gene" promotor_-10 complement(2720911..2720929) /Source="Nicolas_upshift_promotors" /id="U2345" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=517 /SigmaFactorBS="ctaaatatttagtaaatgatgtgatttatgttggaaaaatAA AGGGGAAcccagatctgTCTCGTAAATGTGAAGTAAgcgaataaggaagggtgatggg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2720928) /Source="Nicolas_upshifts" /id="U2345" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=517 /SigmaFactorBS="ctaaatatttagtaaatgatgtgatttatgttggaaaaatAA AGGGGAAcccagatctgTCTCGTAAATGTGAAGTAAgcgaataaggaagggtgatggg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2720940..2720948) /Source="Nicolas_upshift_promotors" /id="U2345" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=517 /SigmaFactorBS="ctaaatatttagtaaatgatgtgatttatgttggaaaaatAA AGGGGAAcccagatctgTCTCGTAAATGTGAAGTAAgcgaataaggaagggtgatggg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2721018..2721025 /Source="Nicolas_upshift_promotors" /id="U2346" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=330 /SigmaFactorBS="agtaaatattatggaatatttcgaaaacaatTATTGTAAccg cttacttttataTGATAATATCAATTTATCAAaaacagatgagttaatattttactaa a" /listShort="msmR, msmE, amyD, amyC, melA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2721041..2721060 /Source="Nicolas_upshift_promotors" /id="U2346" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=330 /SigmaFactorBS="agtaaatattatggaatatttcgaaaacaatTATTGTAAccg cttacttttataTGATAATATCAATTTATCAAaaacagatgagttaatattttactaa a" /listShort="msmR, msmE, amyD, amyC, melA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2721047 /Source="Nicolas_upshifts" /id="U2346" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=330 /SigmaFactorBS="agtaaatattatggaatatttcgaaaacaatTATTGTAAccg cttacttttataTGATAATATCAATTTATCAAaaacagatgagttaatattttactaa a" /listShort="msmR, msmE, amyD, amyC, melA" /GFF_Attribute="listLong" /label="upshifts" CDS 2721106..2722140 /gene="msmR" /locus_tag="BSU_30260" /old_locus_tag="BSU30260" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12847288; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (LacI family)" /protein_id="NP_390904.1" /db_xref="EnsemblGenomes-Gn:BSU30260" /db_xref="EnsemblGenomes-Tr:CAB15004" /db_xref="GOA:O34829" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG12626" /db_xref="UniProtKB/Swiss-Prot:O34829" /translation="MVRIKDIALKAKVSSATVSRILNEDESLSVAGETRQRVINIAEE LGYQTVAKRRKSRGQKQRAQPLIGVLSCLSPDQERQDPYFSSIRKGIEKECFEQEIFI TNSIHLGSFQEHIFRELDGVIVIGRVHDEAVKHISGRLEHAVFINHSPDPQAYDSIGI DFESASRQAIDHLFDLGYKRLGYIGGQEKEHTLKDGQSIRRTIEDKRLTAFLESAAPQ PEHVLIGEYSMREGYRLMKKAIDQGHLPEAFFIASDSMAIGALKALQEAGLQVPRDTA IVSFNGIEEAEFASTPLTTVKVYTEEMGRTGVKLLLDRLNGRTLPQHVTLPTTLIVRQ SCGCTAKEVT*" /label="msmR CDS" gene 2721106..2722140 /gene="msmR" /locus_tag="BSU_30260" /old_locus_tag="BSU30260" /label="msmR gene" promotor_-35 2722089..2722096 /Source="Nicolas_upshift_promotors" /id="U2347" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.72027972027972" /psig="0.72027972027972" /xcortree=350 /SigmaFactorBS="tcaacatgtcaccctgcctacAACATTAAtcgtaagacaaag cTGCGGATGTacagcaaaggaggtgacataagcaaagattcatcacgatgataaggag g" /listShort="msmE, amyD, amyC, melA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2722111..2722119 /Source="Nicolas_upshift_promotors" /id="U2347" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.72027972027972" /psig="0.72027972027972" /xcortree=350 /SigmaFactorBS="tcaacatgtcaccctgcctacAACATTAAtcgtaagacaaag cTGCGGATGTacagcaaaggaggtgacataagcaaagattcatcacgatgataaggag g" /listShort="msmE, amyD, amyC, melA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2722128 /Source="Nicolas_upshifts" /id="U2347" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.72027972027972" /psig="0.72027972027972" /xcortree=350 /SigmaFactorBS="tcaacatgtcaccctgcctacAACATTAAtcgtaagacaaag cTGCGGATGTacagcaaaggaggtgacataagcaaagattcatcacgatgataaggag g" /listShort="msmE, amyD, amyC, melA" /GFF_Attribute="listLong" /label="upshifts" CDS 2722174..2723454 /gene="msmE" /locus_tag="BSU_30270" /old_locus_tag="BSU30270" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8449892, 12847288, 16707683, 18954360, 28036052; Product type lp : lipoprotein" /codon_start=1 /transl_table=11 /product="multiple sugar-binding lipoprotein" /protein_id="NP_390905.1" /db_xref="EnsemblGenomes-Gn:BSU30270" /db_xref="EnsemblGenomes-Tr:CAB15005" /db_xref="GOA:O34335" /db_xref="InterPro:IPR006059" /db_xref="PDB:4R6H" /db_xref="SubtiList:BG12625" /db_xref="UniProtKB/Swiss-Prot:O34335" /translation="MKHTFVLFLSLILLVLPGCSAEKSSADTAKKTLTIYSTMSTDSE RDTFRKLAAAFEKEHSDIHVSLHFPGNDYENMMRVRMAANDLPDLFDTHGWGKIRYGE YTADLRDMKWTQDLDPNLNSILKNKSGKVYAYPINQAKDGLAYNRNILDRYGIAPPET MDDFIKALRTIKEKSKGSIVPFWFAGYDKSSFAQYYDQFATPLLITDPAHNEKKQLIN GTFQWSKFTYLSEILKQMQKEKLINIDAVTAKKSQLIELMAQNKIAFTMQGGTLGQDV AQINPNVKVGIIPTPAIHPGDDPIWIGGERYTLAAWKDSPQLKEAKDFIAFMARPANA KQMAEATSLPSGLTNVKADIFYANDYEYYQDVKVEPYFDRLYLPNGMWDVLGTVGQEL AADILAPQDISQKLGREYKRLREQSETQGAENNE*" /label="msmE CDS" gene 2722174..2723454 /gene="msmE" /locus_tag="BSU_30270" /old_locus_tag="BSU30270" /label="msmE gene" CDS 2723447..2724358 /gene="msmF" /locus_tag="BSU_30280" /old_locus_tag="BSU30280" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1537846, 12847288, 15849754, 16707683, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="carbohydrate ABC transporter (permease)" /protein_id="NP_390906.1" /db_xref="EnsemblGenomes-Gn:BSU30280" /db_xref="EnsemblGenomes-Tr:CAB15006" /db_xref="GOA:O34706" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035277" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12565" /db_xref="UniProtKB/Swiss-Prot:O34706" /translation="MSEIARDVHVKQVKPKKQSSLWWMYIPALLSVLVFMIYPFVKGT LITFTNWNGFSQVYQWVGFAQYERLFSDPDTWHILKNTLHYGLGSTFFQNVVGLLYAL LLNQSIKTKAVTRTIVYLPVMISPLIMGYIWYFFFSYDGGALNDLLGVFGISPINALA SPSLNPWIIVMINTYQYVGIAMVVYLAGLQSIPKDYYEAAQMDGAKQGQQFFTITLPL LMPSITINIVINIIGGLKLFDVIIALTAGGPGNASQSMSTFMYDLYFKRQDAGYAATQ GIFMAFVILIISFCALAYFKRKETEMS*" /label="msmF CDS" gene 2723447..2724358 /gene="msmF" /locus_tag="BSU_30280" /old_locus_tag="BSU30280" /label="msmF gene" CDS 2724355..2725185 /gene="msmG" /locus_tag="BSU_30290" /old_locus_tag="BSU30290" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1537846, 15849754, 16707683, 16850406, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="maltose and multiple sugars ABC transporter (permease)" /protein_id="NP_390907.1" /db_xref="EnsemblGenomes-Gn:BSU30290" /db_xref="EnsemblGenomes-Tr:CAB15007" /db_xref="GOA:O34518" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12564" /db_xref="UniProtKB/Swiss-Prot:O34518" /translation="MRAARTKSMRIITLLAAIVACAHFIPFYILLTTSLKAKGDYSSK WIFPADISFHNFSEAWERASLGNSFINTMIITGFSALLLIIFGSLAAYPLARRETKLN KAVFALLISIMIIPPLTSMVPLYRMVVDAGMVNTHAIAIFINTAAYMPLTVFLYSGFI RSTIPKELVEAARIDGAGMLKIFFTIVFPLLKPITATICIISCVFIWNDYQFAIFFLQ DQKVQTLTVAMAGFFGENANNLHLVAAAALMAMLPMVVLFLALQKYFIAGLSSGAVKG *" /label="msmG CDS" gene 2724355..2725185 /gene="msmG" /locus_tag="BSU_30290" /old_locus_tag="BSU30290" /label="msmG gene" promotor_-35 2725158..2725162 /Source="Nicolas_upshift_promotors" /id="U2348" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig="0.997002997002997" /xcortree=2740 /SigmaFactorBS="tttttggcgctgcaaaaatactttattgccggCCTGTcttcc ggagcggtaaAGGGTTAACATTAAAGGGGGaagcaatatgaaaaagattacatttatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2725178..2725197 /Source="Nicolas_upshift_promotors" /id="U2348" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig="0.997002997002997" /xcortree=2740 /SigmaFactorBS="tttttggcgctgcaaaaatactttattgccggCCTGTcttcc ggagcggtaaAGGGTTAACATTAAAGGGGGaagcaatatgaaaaagattacatttatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2725186 /Source="Nicolas_upshifts" /id="U2348" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig="0.997002997002997" /xcortree=2740 /SigmaFactorBS="tttttggcgctgcaaaaatactttattgccggCCTGTcttcc ggagcggtaaAGGGTTAACATTAAAGGGGGaagcaatatgaaaaagattacatttatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 2725205..2726503 /gene="melA" /locus_tag="BSU_30300" /old_locus_tag="BSU30300" /EC_number="3.2.1.22" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12847288; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alpha-D-galactoside galactohydrolase" /protein_id="NP_390908.1" /db_xref="EnsemblGenomes-Gn:BSU30300" /db_xref="EnsemblGenomes-Tr:CAB15008" /db_xref="GOA:O34645" /db_xref="InterPro:IPR001088" /db_xref="InterPro:IPR015955" /db_xref="InterPro:IPR019802" /db_xref="InterPro:IPR022616" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12615" /db_xref="UniProtKB/Swiss-Prot:O34645" /translation="MKKITFIGAGSTIFAKNVLGDCLLTEALNGFEFALYDIDPKRLQ ESQLMLENLRDRYNPSVAINSYDDRKLALQNAGYVINAIQVGGYKPSTVIDFEIPKRY GLRQTIADTVGIGGIFRSLRTIPVLFDIAKDMEEMCPDAWFLNYTNPMATLTGAMLRY TNIKTIGLCHSVQVCTKDLFKALGMEHDGIEERIAGINHMAWLLEVKKDGTDLYPEIK RRAKEKQKTKHHDMVRFELMDKFGYYVTESSEHNAEYHPYFIKRNYPELISELQIPLD EYPRRCVKQIENWEKMRDDIVNNKNLTHERSKEYGSRIIEAMETNEPFTFGGNVLNTG LITNLPSKAVVEVTCVADRKKITPCFAGELPEQLAALNRTNINTQLMTIEAAVTRKKE AVYQAAMLDPHTSAELSMKDIISMCDDLFAAHGDWLPEYK*" /label="melA CDS" gene 2725205..2726503 /gene="melA" /locus_tag="BSU_30300" /old_locus_tag="BSU30300" /label="melA gene" downshifts 2726484 /Source="Nicolas_upshifts" /id="D1557" /incds=0 /nref=12 /ntot=55 /MaxReadThrough="3.99614" /MaxDrop="3.96455" /score="26.0469828" /energy="-11.9" /TU="NA" /idTUdmin="U2346" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2726525..2726836) /gene="ytwF" /locus_tag="BSU_30310" /old_locus_tag="BSU30310" /EC_number="2.8.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10939241, 22730127; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sulfur transferase" /protein_id="NP_390909.2" /db_xref="EnsemblGenomes-Gn:BSU30310" /db_xref="EnsemblGenomes-Tr:CAB15009" /db_xref="GOA:O32072" /db_xref="InterPro:IPR001763" /db_xref="InterPro:IPR036873" /db_xref="SubtiList:BG13932" /db_xref="UniProtKB/Swiss-Prot:O32072" /translation="MEIKEISTAALKEKIEADEELYLIDVREDEEVAEGMIPQAVHIR MGDIPEKMETLDKDKEYVFICRSGMRSMNVCKYLDEQGFKTVNVEGGMMAWEGETKPK N*" /label="ytwF CDS" gene complement(2726525..2726836) /gene="ytwF" /locus_tag="BSU_30310" /old_locus_tag="BSU30310" /label="ytwF gene" downshifts complement(2726536) /Source="Nicolas_upshifts" /id="D1558" /incds=0 /nref=84 /ntot=254 /MaxReadThrough="2.71726" /MaxDrop="5.77228" /score="23.1306393" /energy="-11.9" /TU="NA" /idTUdmin="U2349" /TUdmin="-20" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2726860..2726879) /Source="Nicolas_upshift_promotors" /id="U2349" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.58941058941059" /psig="0.999000999001" /xcortree=1932 /SigmaFactorBS="aaaggggattttttttcatcagtctcaGAATAGCAatcgttc ggctgacTTTGATATACTGAACATGATcactgtgaataggagtgttttctttggaaat a" /listShort="ytwF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2726868) /Source="Nicolas_upshifts" /id="U2349" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.58941058941059" /psig="0.999000999001" /xcortree=1932 /SigmaFactorBS="aaaggggattttttttcatcagtctcaGAATAGCAatcgttc ggctgacTTTGATATACTGAACATGATcactgtgaataggagtgttttctttggaaat a" /listShort="ytwF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2726894..2726901) /Source="Nicolas_upshift_promotors" /id="U2349" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.58941058941059" /psig="0.999000999001" /xcortree=1932 /SigmaFactorBS="aaaggggattttttttcatcagtctcaGAATAGCAatcgttc ggctgacTTTGATATACTGAACATGATcactgtgaataggagtgttttctttggaaat a" /listShort="ytwF" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2726902 /Source="Nicolas_upshifts" /id="D1559" /incds=0 /nref=3 /ntot=17 /MaxReadThrough="0.749090000000001" /MaxDrop="4.59307" /score="20.1681452" /energy="-11.2" /TU="NA" /idTUdmin="U2346" /TUdmin=418 /isTUend="FALSE" /label="downshifts" CDS complement(2726953..2729367) /gene="leuS" /locus_tag="BSU_30320" /old_locus_tag="BSU30320" /EC_number="6.1.1.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 1317842" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 1317842; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="leucyl-tRNA synthetase" /protein_id="NP_390910.1" /db_xref="EnsemblGenomes-Gn:BSU30320" /db_xref="EnsemblGenomes-Tr:CAB15010" /db_xref="GOA:P36430" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR002300" /db_xref="InterPro:IPR002302" /db_xref="InterPro:IPR009008" /db_xref="InterPro:IPR009080" /db_xref="InterPro:IPR013155" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR015413" /db_xref="InterPro:IPR025709" /db_xref="SubtiList:BG10676" /db_xref="UniProtKB/Swiss-Prot:P36430" /translation="MSFQHKEIEKKWQTYWLENKTFATLDNNEKQKFYALDMFPYPSG AGLHVGHPEGYTATDILSRMKRMQGYDVLHPMGWDAFGLPAEQYALDTGNDPAVFTKQ NIDNFRRQIQALGFSYDWDREINTTDPEYYKWTQWIFLKLYEKGLAYVDEVPVNWCPA LGTVLANEEVIDGKSERGGHPVERRPMKQWMLKITAYADRLLEDLEELDWPESIKDMQ RNWIGRSEGAHVHFAIDGHDDSFTVFTTRPDTLFGATYTVLAPEHALVENITTAEQKE AVEAYIKEIQSKSDLERTDLAKTKTGVFTGAYAINPVNGEKLPIWIADYVLASYGTGA VMAVPGHDERDFEFAKTFGLPVKEVVKGGNVEEAAYTGDGEHVNSDFLNGLHKQEAIE KVIAWLEETKNGEKKVTYRLRDWLFSRQRYWGEPIPVIHWEDGTSTAVPEEELPLILP KTDEIKPSGTGESPLANIKEWVEVTDPETGKKGRRETNTMPQWAGSCWYFLRYIDPHN PDQLASPEKLEKWLPVDMYIGGAEHAVLHLLYARFWHKFLYDIGVVPTKEPFQKLYNQ GMILGENNEKMSKSKGNVVNPDEIVASHGADTLRLYEMFMGPLDASIAWSESGLDGAR RFLDRVWRLFIEDSGELNGKIVEGAGETLERVYHETVMKVTDHYEGLRFNTGISQLMV FINEAYKATELPKEYMEGFVKLLSPVAPHLAEELWEKLGHSGTIAYEAWPVYDETKLV DDEVEIVVQLNGKVKAKLQVPADATKEQLEQLAQADEKVKEQLEGKTIRKIIAVPGKL VNIVAN*" /label="leuS CDS" gene complement(2726953..2729367) /gene="leuS" /locus_tag="BSU_30320" /old_locus_tag="BSU30320" /label="leuS gene" downshifts complement(2726957) /Source="Nicolas_upshifts" /id="D1560" /incds=0 /nref=115 /ntot=224 /MaxReadThrough="3.2803" /MaxDrop="4.46738" /score="33.3300042" /energy="-11.2" /TU="U2350" /idTUdmin="U2350" /TUdmin="-67" /isTUend="FALSE" /label="downshifts" S_feature complement(2729368..2729463) /Source="Nicolas_S_feature" /locus_tag="new_3105044_3105139_c" /HighExp="G150, G180, G135, LBGexp, HPh, LBGtran, Paraq, Lbexp, H2O2, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.989" /label="S1156" misc_RNA complement(2729477..2729691) /gene="tboL" /locus_tag="BSU_misc_RNA_49" /product="T-box riboswitch specific of leucine tRNA ligase" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 1317842, 9098041, 12165569, 12547201, 27169680; Product type n: RNA" /function="16.3: Control" /label="tboL RNA" gene complement(2729477..2729691) /gene="tboL" /locus_tag="BSU_misc_RNA_49" /label="tboL gene" downshifts complement(2729508) /Source="Nicolas_upshifts" /id="D1561" /incds=0 /nref=8 /ntot=38 /MaxReadThrough="6.86098" /MaxDrop="4.90189" /score="40.6873438" /energy="-16.7" /TU="U2350" /idTUdmin="U2352" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2729703..2729722) /Source="Nicolas_upshift_promotors" /id="U2350" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.444555444555445" /psig=1 /xcortree=2672 /SigmaFactorBS="atctccgcccgttcagggtacattcccattgtatacaaacct GCTTGCacttatgaacagaaTTCTATAAAATACAGTTAGAttacggttgcgataagaa c" /listShort="NA, S1156, leuS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2729724) /Source="Nicolas_upshifts" /id="U2350" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.444555444555445" /psig=1 /xcortree=2672 /SigmaFactorBS="atctccgcccgttcagggtacattcccattgtatacaaacct GCTTGCacttatgaacagaaTTCTATAAAATACAGTTAGAttacggttgcgataagaa c" /listShort="NA, S1156, leuS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2729728..2729733 /Source="Nicolas_upshift_promotors" /id="U2351" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=1009 /SigmaFactorBS="atctaactgtattttatagaattctgTTCATAagtgcaagca ggtttGTATACAATGGGAATGTACcctgaacgggcggagattgaggacaattattcgg g" /listShort="S1157" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2729737..2729742) /Source="Nicolas_upshift_promotors" /id="U2350" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.444555444555445" /psig=1 /xcortree=2672 /SigmaFactorBS="atctccgcccgttcagggtacattcccattgtatacaaacct GCTTGCacttatgaacagaaTTCTATAAAATACAGTTAGAttacggttgcgataagaa c" /listShort="NA, S1156, leuS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2729749..2729767 /Source="Nicolas_upshift_promotors" /id="U2351" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=1009 /SigmaFactorBS="atctaactgtattttatagaattctgTTCATAagtgcaagca ggtttGTATACAATGGGAATGTACcctgaacgggcggagattgaggacaattattcgg g" /listShort="S1157" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2729762..2730202 /Source="Nicolas_S_feature" /locus_tag="new_3105438_3105878" /HighExp="S4, S5, S3, S8, S7, S6, T5.0H, LoTm, C30, M9-stat" /AntisenseName="ytvB" /AntisenseCor="0.57398798861917499" /AntisenseRegPval="-24.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.978" /TUlongSig="NA" /TUlongPSig="NA" /label="S1157" upshifts 2729762 /Source="Nicolas_upshifts" /id="U2351" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=1009 /SigmaFactorBS="atctaactgtattttatagaattctgTTCATAagtgcaagca ggtttGTATACAATGGGAATGTACcctgaacgggcggagattgaggacaattattcgg g" /listShort="S1157" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2729794..2730129) /gene="ytvB" /locus_tag="BSU_30330" /old_locus_tag="BSU30330" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16923906; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative conserved membrane protein" /protein_id="NP_390911.3" /db_xref="EnsemblGenomes-Gn:BSU30330" /db_xref="EnsemblGenomes-Tr:CAB15011" /db_xref="GOA:O34881" /db_xref="InterPro:IPR025353" /db_xref="SubtiList:BG13929" /db_xref="UniProtKB/Swiss-Prot:O34881" /translation="MKMLHQVLIACVIGGIMGILGHVKKRGRLEKPRMTKRFIYLGFL EDWFIGMTASILLVLSADPDSGIQLVILSIISGYGGEAVLRSFDFVRELNSGGEPAES KRQTKTPPE*" /label="ytvB CDS" gene complement(2729794..2730129) /gene="ytvB" /locus_tag="BSU_30330" /old_locus_tag="BSU30330" /label="ytvB gene" S_feature complement(2730124..2730388) /Source="Nicolas_S_feature" /locus_tag="new_3105800_3106064_c" /HighExp="S6, S8, S7, Etha, S5, M9-stat, B60, BT, B36, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S1158" promotor_-10 complement(2730373..2730392) /Source="Nicolas_upshift_promotors" /id="U2352" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig="0.98901098901099" /xcortree=780 /SigmaFactorBS="aacacatgttctgattcaagcaagtgcagtttgtTGTTTGTC attagggcttgtccTCGTATACACTAAAAATAAGaacagaatttgaacatatgaacgg a" /listShort="S1158, ytvB, NA" /listLong="S1156, leuS" /label="promotor_-10" upshifts complement(2730388) /Source="Nicolas_upshifts" /id="U2352" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig="0.98901098901099" /xcortree=780 /SigmaFactorBS="aacacatgttctgattcaagcaagtgcagtttgtTGTTTGTC attagggcttgtccTCGTATACACTAAAAATAAGaacagaatttgaacatatgaacgg a" /listShort="S1158, ytvB, NA" /listLong="S1156, leuS" /label="upshifts" promotor_-35 complement(2730407..2730414) /Source="Nicolas_upshift_promotors" /id="U2352" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig="0.98901098901099" /xcortree=780 /SigmaFactorBS="aacacatgttctgattcaagcaagtgcagtttgtTGTTTGTC attagggcttgtccTCGTATACACTAAAAATAAGaacagaatttgaacatatgaacgg a" /listShort="S1158, ytvB, NA" /listLong="S1156, leuS" /label="promotor_-35" promotor_-35 2730427..2730434 /Source="Nicolas_upshift_promotors" /id="U2353" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.887112887112887" /psig="0.997002997002997" /xcortree=2073 /SigmaFactorBS="aatgacaaacaacaaactgcactTGCTTGAAtcagaacatgt gtTGTGCTACGGTTACTGTAGAattcatttttaaaaaggggaatatcaggctttcgca t" /listShort="S1159, ytvA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2730448..2730467 /Source="Nicolas_upshift_promotors" /id="U2353" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.887112887112887" /psig="0.997002997002997" /xcortree=2073 /SigmaFactorBS="aatgacaaacaacaaactgcactTGCTTGAAtcagaacatgt gtTGTGCTACGGTTACTGTAGAattcatttttaaaaaggggaatatcaggctttcgca t" /listShort="S1159, ytvA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2730464 /Source="Nicolas_upshifts" /id="U2353" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.887112887112887" /psig="0.997002997002997" /xcortree=2073 /SigmaFactorBS="aatgacaaacaacaaactgcactTGCTTGAAtcagaacatgt gtTGTGCTACGGTTACTGTAGAattcatttttaaaaaggggaatatcaggctttcgca t" /listShort="S1159, ytvA" /GFF_Attribute="listLong" /label="upshifts" S_feature 2730466..2730533 /Source="Nicolas_S_feature" /locus_tag="new_3106142_3106209" /HighExp="M40t90, Etha, dia5, HiOs, dia15, H2O2, BC, Diami, M0t90, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1159" CDS 2730534..2731319 /gene="blrA" /locus_tag="BSU_30340" /old_locus_tag="BSU30340" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11964249, 16923906, 16923909, 17200735, 17443319, 17575448, 19948797, 21259411, 21851109, 23416074, 24171435, 25211155, 27203230, 28502782, 28632317" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11964249, 16923906, 16923909, 17200735, 17443319, 17575448, 19948797, 21259411, 21851109, 23416074, 24171435, 25211155, 27203230, 28502782, 28632317; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="blue light GTP-binding receptor" /protein_id="NP_390912.1" /db_xref="EnsemblGenomes-Gn:BSU30340" /db_xref="EnsemblGenomes-Tr:CAB15012" /db_xref="GOA:O34627" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR000700" /db_xref="InterPro:IPR001610" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036513" /db_xref="PDB:1IUM" /db_xref="PDB:2MWG" /db_xref="PDB:2PR5" /db_xref="PDB:2PR6" /db_xref="PDB:4GCZ" /db_xref="SubtiList:BG13928" /db_xref="UniProtKB/Swiss-Prot:O34627" /translation="MASFQSFGIPGQLEVIKKALDHVRVGVVITDPALEDNPIVYVNQ GFVQMTGYETEEILGKNCRFLQGKHTDPAEVDNIRTALQNKEPVTVQIQNYKKDGTMF WNELNIDPMEIEDKTYFVGIQNDITKQKEYEKLLEDSLTEITALSTPIVPIRNGISAL PLVGNLTEERFNSIVCTLTNILSTSKDDYLIIDLSGLAQVNEQTADQIFKLSHLLKLT GTELIITGIKPELAMKMNKLDANFSSLKTYSNVKDAVKVLPIM*" /label="blrA CDS" gene 2730534..2731319 /gene="blrA" /locus_tag="BSU_30340" /old_locus_tag="BSU30340" /label="blrA gene" S_feature 2731320..2731376 /Source="Nicolas_S_feature" /locus_tag="new_3106996_3107052" /HighExp="Sw, M40t90, BC, Etha, dia5, dia15, H2O2, Mt0, M0t90, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1160" CDS complement(2731556..2732749) /gene="yttB" /locus_tag="BSU_30350" /old_locus_tag="BSU30350" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11988534, 15849754, 16850406, 28472044; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_390913.1" /db_xref="EnsemblGenomes-Gn:BSU30350" /db_xref="EnsemblGenomes-Tr:CAB15013" /db_xref="GOA:O34546" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13925" /db_xref="UniProtKB/Swiss-Prot:O34546" /translation="MPRALKILVIGMFINVTGASFLWPLNTIYIHNHLGKSLTVAGLV LMLNSGASVAGNLCGGFLFDKIGGFKSIMLGIAITLASLMGLVFFHDWPAYIVLLTIV GFGSGVVFPASYAMAGSVWPEGGRKAFNAIYVAQNAGVAVGSALGGVVASFSFSYVFL ANAVLYLIFFFIVYFGFRNIQTGDASQTSVLDYDAVNSKAKFAALIILSGGYVLGWLA YSQWSTTIASYTQSIGISLSLYSVLWTVNGILIVLGQPLVSFVVKKWAESLKAQMVIG FIIFIVSFSMLLTAKQFPMFLAAMVILTIGEMLVWPAVPTIANQLAPKGKEGFYQGFV NSAATGGRMIGPLFGGVLVDHYGIRALVLSLLVLLLISIATTLLYDKRIKSAKETNKQ ASISS*" /label="yttB CDS" gene complement(2731556..2732749) /gene="yttB" /locus_tag="BSU_30350" /old_locus_tag="BSU30350" /label="yttB gene" downshifts complement(2731576) /Source="Nicolas_upshifts" /id="D1562" /incds=0 /nref=5 /ntot=47 /MaxReadThrough="2.03991" /MaxDrop="3.41948" /score="-7.70376219" /energy="-9.4" /TU="NA" /idTUdmin="U2354" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2732750..2732848) /Source="Nicolas_S_feature" /locus_tag="new_3108426_3108524_c" /HighExp="dia15, LBGstat, H2O2, G180, LPhT, Paraq, Oxctl, G150, G135, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1161" promotor_-10 complement(2732829..2732848) /Source="Nicolas_upshift_promotors" /id="U2354" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2464 /SigmaFactorBS="atttttcaaacaatatttgttagattttttcacgctcatCAG TTGAAaaatgtgagagagACAGATAGAATGAATGTGCTatgataactggattcgtacg g" /listShort="S1161, yttB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2732848) /Source="Nicolas_upshifts" /id="U2354" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2464 /SigmaFactorBS="atttttcaaacaatatttgttagattttttcacgctcatCAG TTGAAaaatgtgagagagACAGATAGAATGAATGTGCTatgataactggattcgtacg g" /listShort="S1161, yttB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2732862..2732869) /Source="Nicolas_upshift_promotors" /id="U2354" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2464 /SigmaFactorBS="atttttcaaacaatatttgttagattttttcacgctcatCAG TTGAAaaatgtgagagagACAGATAGAATGAATGTGCTatgataactggattcgtacg g" /listShort="S1161, yttB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2732886..2732889 /Source="Nicolas_upshift_promotors" /id="U2355" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig="0.987012987012987" /xcortree=3214 /SigmaFactorBS="tctctctcacatttttcaactgatgagcgtgaaaaaatCTAA caaatattgtttgaAAAATGTAAAATAAATAGAAaaaggggtcatattatggaaatgg t" /listShort="yttA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2732904..2732923 /Source="Nicolas_upshift_promotors" /id="U2355" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig="0.987012987012987" /xcortree=3214 /SigmaFactorBS="tctctctcacatttttcaactgatgagcgtgaaaaaatCTAA caaatattgtttgaAAAATGTAAAATAAATAGAAaaaggggtcatattatggaaatgg t" /listShort="yttA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2732908 /Source="Nicolas_upshifts" /id="U2355" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig="0.987012987012987" /xcortree=3214 /SigmaFactorBS="tctctctcacatttttcaactgatgagcgtgaaaaaatCTAA caaatattgtttgaAAAATGTAAAATAAATAGAAaaaggggtcatattatggaaatgg t" /listShort="yttA" /GFF_Attribute="listLong" /label="upshifts" CDS 2732938..2733684 /gene="yttA" /locus_tag="BSU_30360" /old_locus_tag="BSU30360" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12823818" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390914.2" /db_xref="EnsemblGenomes-Gn:BSU30360" /db_xref="EnsemblGenomes-Tr:CAB15014" /db_xref="GOA:Q795Q5" /db_xref="InterPro:IPR006876" /db_xref="InterPro:IPR035451" /db_xref="SubtiList:BG13924" /db_xref="UniProtKB/Swiss-Prot:Q795Q5" /translation="MEMVLAFLGFLACLIALGYGLYHLVRYVLKKEKRFSKRLFWPLF IGGLVLLFTGAALAEPDTAAANAEKKYSALNAEYKNLTKEHEELEKEYKSVSSEAKKL KDNKEDQDKLEKLKNENSDLKKTQKSLKAEIKELQENQKQLKEDAKTAKAENETLRQD KTKLENQLKETESQTASSHEDTGSSSNNTSKSDETKTADKAEGCNIKGSRNGIYHTPG STYYDRTTDPAEMFCSVEEAEAAGYRAPKR*" /label="yttA CDS" gene 2732938..2733684 /gene="yttA" /locus_tag="BSU_30360" /old_locus_tag="BSU30360" /label="yttA gene" downshifts 2733579 /Source="Nicolas_upshifts" /id="D1563" /incds=1 /nref=2 /ntot=94 /MaxReadThrough="4.11368" /MaxDrop="3.01036" /score="23.2955589" /energy="-11.6" /TU="U2355" /idTUdmin="U2355" /TUdmin="-99" /isTUend="FALSE" /label="downshifts" downshifts 2733678 /Source="Nicolas_upshifts" /id="D1564" /incds=0 /nref=31 /ntot=169 /MaxReadThrough="1.73994" /MaxDrop="4.19129" /score="23.2955589" /energy="-11.6" /TU="NA" /idTUdmin="U2355" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2733721..2735661) /gene="bceB" /locus_tag="BSU_30370" /old_locus_tag="BSU30370" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:14612242, 15849754, 16850406, 17905982, 25118291" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14612242, 15849754, 16850406, 17905982, 25118291; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (permease)" /protein_id="NP_390915.1" /db_xref="EnsemblGenomes-Gn:BSU30370" /db_xref="EnsemblGenomes-Tr:CAB15015" /db_xref="GOA:O34741" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR027022" /db_xref="SubtiList:BG13921" /db_xref="UniProtKB/Swiss-Prot:O34741" /translation="MNINQLILRNLKKNLRNYYLYVFALIFSVALYFAFVTLQYDPAI NEVKASIKGAAAIKTASILLVAVVAIFILYANTIFIKRRSKEIGLFQLIGMTKHKIFR ILSAENVMLYFGSLAIGVAAGFSISKLVLMILFKIVDVKADAKLHFSEQALVQTVIVF CGIYLLIMIMNYTFIKKQSILSLFKVTSSTEDKVKKISFFQMLIGALGIVLILTGYYV SSELFGGKFKTINELFVAMSFILGSVIIGTFLFYKGSVTFISNIIRKSKGGYLNISEV LSLSSIMFRMKSNALLLTIITTVSALAIGLLSLAYISYYSSEKTAEQNVAADFSFMNE KDAKLFENKLRESNISFVKKATPVLQANVDIANIMDGTPKEMQGDPGNMQLAVVSDKD VKGVDVAAGEAVFSGYTDLLQKIMVFKDSGVIKVKSKHETQPLKYKGLREEFLVSYTF TSGGMPAVIVDDSLFKQLDKDKDPRIQLAQSTFIGVNVKHDDQMEKANELFQQVNKKN EHLSRLDTSAAQKSLFGMVMFIVGFLGLTFLITSGCILYFKQMGESEDEKPSYTILRK LGFTQGDLIKGIRIKQMYNFGIPLVVGLFHSYFAVQSGWFLFGSEVWAPMIMVMVLYT ALYSIFGFLSVLYYKKVIKSSL*" /label="bceB CDS" gene complement(2733721..2735661) /gene="bceB" /locus_tag="BSU_30370" /old_locus_tag="BSU30370" /label="bceB gene" downshifts complement(2733732) /Source="Nicolas_upshifts" /id="D1565" /incds=0 /nref=13 /ntot=89 /MaxReadThrough="1.56566" /MaxDrop="4.45006" /score="29.4802229" /energy="-11.6" /TU="NA" /idTUdmin="U2356" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2735651..2736412) /gene="bceA" /locus_tag="BSU_30380" /old_locus_tag="BSU30380" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:14612242, 17905982, 25118291" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14612242, 17905982, 25118291; Product type t: transporter" /codon_start=1 /transl_table=11 /product="bacitracin ABC efflux transporter (ATP-binding protein)" /protein_id="NP_390916.1" /db_xref="EnsemblGenomes-Gn:BSU30380" /db_xref="EnsemblGenomes-Tr:CAB15016" /db_xref="GOA:O34697" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13920" /db_xref="UniProtKB/Swiss-Prot:O34697" /translation="MVILEANKIRKSYGNKLNKQEVLKGIDIHIEKGEFVSIMGASGS GKTTLLNVLSSIDQVSHGTIHINGNDMTAMKEKQLAEFRKQHLGFIFQDYNLLDTLTV KENILLPLSITKLSKKEANRKFEEVAKELGIYELRDKYPNEISGGQKQRTSAGRAFIH DPSIIFADEPTGALDSKSASDLLNKLSQLNQKRNATIIMVTHDPVAASYCGRVIFIKD GQMYTQLNKGGQDRQTFFQDIMKTQGVLGGVQHEH*" /label="bceA CDS" gene complement(2735651..2736412) /gene="bceA" /locus_tag="BSU_30380" /old_locus_tag="BSU30380" /label="bceA gene" misc_feature complement(2736436..2736454) /Source="Nicolas_upshift_promotors" /id="U2356" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.383616383616384" /psig="0.83016983016983" /xcortree=3191 /SigmaFactorBS="gacgaaaatgtcacatgcttttcttttttgttcgccgtatcg aaggaaaagcccggcattcCTTTTTATAATGAGATTATccaatataaaggagactgcg t" /listShort="bceA, bceB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2736455) /Source="Nicolas_upshifts" /id="U2356" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.383616383616384" /psig="0.83016983016983" /xcortree=3191 /SigmaFactorBS="gacgaaaatgtcacatgcttttcttttttgttcgccgtatcg aaggaaaagcccggcattcCTTTTTATAATGAGATTATccaatataaaggagactgcg t" /listShort="bceA, bceB" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2736514..2737518) /gene="bceS" /locus_tag="BSU_30390" /old_locus_tag="BSU30390" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 17905982, 25118291, 25685323" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 17905982, 25118291, 25685323; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase controlling resistance to antibiotics affecting the envelope [YtsA]" /protein_id="NP_390917.1" /db_xref="EnsemblGenomes-Gn:BSU30390" /db_xref="EnsemblGenomes-Tr:CAB15017" /db_xref="GOA:O35044" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG13919" /db_xref="UniProtKB/Swiss-Prot:O35044" /translation="MIKAFLIERRSWIAAFLFQQALMLFIAFVDPSISFGNVLYMVYL CILFFIIFLWFRYRKETAFYKSLKTWENNLDVTAINEPETPFEAMVERSIAGQTEHLK QTAARHRLALENEKDELMAWIHEVKTPLTAMHLIIDRMEEKALKSQLSYEWLRIHLLL DQQLHQKRISFIENDLSVEFIQLQPLIFKEIKDLQSWCIQKGIGFDIQLEAKEVLSDA KWLAFIIRQLLTNAVKYSEASEIEIKSFQKGEQTQLQVKDCGRGIDPKDVPRIFDKGF TSTTDHHDQASTGMGLYLAKKAAAPLLIHIDVESEFGAGTVFTLTFPIRNQFEHVISV *" /label="bceS CDS" gene complement(2736514..2737518) /gene="bceS" /locus_tag="BSU_30390" /old_locus_tag="BSU30390" /label="bceS gene" downshifts complement(2736553) /Source="Nicolas_upshifts" /id="D1566" /incds=0 /nref=25 /ntot=187 /MaxReadThrough="2.40611" /MaxDrop="4.6482" /score="29.3236847" /energy="-13.9" /TU="NA" /idTUdmin="U2357" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" CDS complement(2737511..2738206) /gene="bceR" /locus_tag="BSU_30400" /old_locus_tag="BSU30400" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 17905982, 25118291, 25685323, 27997719" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 17905982, 25118291, 25685323, 27997719; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator controlling resistance to antibiotics affecting the envelope [YtsB]" /protein_id="NP_390918.1" /db_xref="EnsemblGenomes-Gn:BSU30400" /db_xref="EnsemblGenomes-Tr:CAB15018" /db_xref="GOA:O34951" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12340" /db_xref="UniProtKB/Swiss-Prot:O34951" /translation="MFKLLLIEDDESLFHEIKDRLTGWSYDVYGIQDFSQVLQEFAAV NPDCVIIDVQLPKFDGFHWCRLIRSRSNVPILFLSSRDHPADMVMSMQLGADDFIQKP FHFDVLIAKIQAMFRRVHHYNTEPSTIKTWCGAAVDAEQNLVSNDKGSVELTKNEMFI LKQLIEQKNKIVSREELIRSLWNDERFVSDNTLTVNVNRLRKKLDALQLGAYIETKVG QGYIAKEEDKFYD*" /label="bceR CDS" gene complement(2737511..2738206) /gene="bceR" /locus_tag="BSU_30400" /old_locus_tag="BSU30400" /label="bceR gene" promotor_-10 complement(2738230..2738248) /Source="Nicolas_upshift_promotors" /id="U2357" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.47952047952048" /psig="0.987012987012987" /xcortree=3119 /SigmaFactorBS="tgcgaacgagccggctgagacagccggctttttctATAGcgc atgctggcgtttTGCTATACACTTGATAAAAaaggaaaaagtgcggtgagtcgattgt t" /listShort="bceR, bceS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2738242) /Source="Nicolas_upshifts" /id="U2357" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.47952047952048" /psig="0.987012987012987" /xcortree=3119 /SigmaFactorBS="tgcgaacgagccggctgagacagccggctttttctATAGcgc atgctggcgtttTGCTATACACTTGATAAAAaaggaaaaagtgcggtgagtcgattgt t" /listShort="bceR, bceS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2738264..2738267) /Source="Nicolas_upshift_promotors" /id="U2357" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.47952047952048" /psig="0.987012987012987" /xcortree=3119 /SigmaFactorBS="tgcgaacgagccggctgagacagccggctttttctATAGcgc atgctggcgtttTGCTATACACTTGATAAAAaaggaaaaagtgcggtgagtcgattgt t" /listShort="bceR, bceS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2738303..2739613) /gene="ytrF" /locus_tag="BSU_30410" /old_locus_tag="BSU30410" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10986249, 15849754, 16850406, 17558661, 22926563" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986249, 15849754, 16850406, 17558661, 22926563; Product type t : transporter" /codon_start=1 /transl_table=11 /product="metabolite permease involved in resistance to cell wall inhibitors" /protein_id="NP_390919.1" /db_xref="EnsemblGenomes-Gn:BSU30410" /db_xref="EnsemblGenomes-Tr:CAB15019" /db_xref="GOA:O35005" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR025857" /db_xref="SubtiList:BG13916" /db_xref="UniProtKB/Swiss-Prot:O35005" /translation="MRFKDQVHFIRRNMKKNRLRVFMTILATTMACAFLVVLSSVGFG IQKTITDMTMSQQIVTKVSVMGKEGDKPIKKADLEKYDHVRSVVERTQVYEPNKATLG NRTNESSNLIFTNMNDELKANMELEKGRVAKSENEIVVGYDFAKRLLTKKESEEYNKK IEEAKGNPEDIKEPKGYTKDILNKTIELSVSKTDSKTGDVTKTKTYDFKIVGITKKPS QDWMEDSNIFISDQFKKDFSEFLDFKGGNVETNIGVFADKFENVEQLTNDLTDDGYYV TSVTTELEGANTFFMVFKIGLIFVGCIAVIISAIGIFNTMTMAVTERTQEIGIMKAIG ASPSIIRRMFLMESAYIGILGCVIGIIISYGVSYLVNLAVPMILAATSGGDAGDLNYT FSYIPASLVIIAVVICGGVAVISGMNPARKATKTNVLTALRREL*" /label="ytrF CDS" gene complement(2738303..2739613) /gene="ytrF" /locus_tag="BSU_30410" /old_locus_tag="BSU30410" /label="ytrF gene" downshifts complement(2738325) /Source="Nicolas_upshifts" /id="D1567" /incds=0 /nref=9 /ntot=170 /MaxReadThrough="4.26891" /MaxDrop="3.83905" /score="28.2472037" /energy="-13.6" /TU="U2359" /idTUdmin="U2359" /TUdmin="-1755" /isTUend="FALSE" /label="downshifts" CDS complement(2739603..2740298) /gene="ytrE" /locus_tag="BSU_30420" /old_locus_tag="BSU30420" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10986249, 22720735, 22926563" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986249, 22720735, 22926563; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (ATP-binding protein) involved in resistance to cell wall inhibitors" /protein_id="NP_390920.1" /db_xref="EnsemblGenomes-Gn:BSU30420" /db_xref="EnsemblGenomes-Tr:CAB15020" /db_xref="GOA:O34392" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13915" /db_xref="UniProtKB/Swiss-Prot:O34392" /translation="MIDVQHIDHSFTIGKKGRENEVPVLKDVSLSVAKGEIACIVGRS GSGKSTLLNLISGYISPTKGRIVINGTDVTGFNEKEWAQFRLDHFGFIFQSFQLIPGL TTYENVEMPLALKGIKPSERKQKVQDMLKRVGLENHAAHYPNELSGGQQQRVSIARAL ILNPSIILADEPTGSLDSETEHEVLELIQQLNRERGITFVIITHDDEVASIGHSKFQL HDGVLKGGITVEV*" /label="ytrE CDS" gene complement(2739603..2740298) /gene="ytrE" /locus_tag="BSU_30420" /old_locus_tag="BSU30420" /label="ytrE gene" CDS complement(2740313..2741290) /gene="ytrD" /locus_tag="BSU_30430" /old_locus_tag="BSU30430" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10986249, 15849754, 16850406, 17558661, 22926563" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986249, 15849754, 16850406, 17558661, 22926563; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC transporter, permease component involved in resistance to cell wall inhibitors" /protein_id="NP_390921.1" /db_xref="EnsemblGenomes-Gn:BSU30430" /db_xref="EnsemblGenomes-Tr:CAB15021" /db_xref="GOA:O34953" /db_xref="InterPro:IPR023264" /db_xref="SubtiList:BG13914" /db_xref="UniProtKB/Swiss-Prot:O34953" /translation="MPDSGLLYKEWRQNKVALVITILVFILGNPLSILNMYLIYQGCV TGKENWVGPCVFSVDYLNSSFISLFWIWGVVLAVSQLGIERSKSFFDFTLSLPYTRGQ IFHAKFLTGGMVIVVPQLIGYVLSVLLIMLLKPDQAVYFHNYSLGMIIVSMLAYSLVM AGGALTGNSFAQLLVSFTVAISPFLLISLPVINLEILFGGSIDFIHGPVPKWVQYFIP IIYVDSKWAENSPYYLVIPAIMTIIFYIIGYISFVKMSNERNGYFFLWKPLNRPVQII VIIIGIMGFGYFGFTASESFAGYLIGMGTGAVIGFLISYFAIYKKMKLL*" /label="ytrD CDS" gene complement(2740313..2741290) /gene="ytrD" /locus_tag="BSU_30430" /old_locus_tag="BSU30430" /label="ytrD gene" CDS complement(2741320..2742306) /gene="ytrC" /locus_tag="BSU_30440" /old_locus_tag="BSU30440" /experiment="publication(s) with functional evidences, PMID:10986249, 15849754, 16850406, 17558661, 22926563" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986249, 15849754, 16850406, 17558661, 22926563; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC transporter, permease component involved in resistance to cell wall inhibitors" /protein_id="NP_390922.1" /db_xref="EnsemblGenomes-Gn:BSU30440" /db_xref="EnsemblGenomes-Tr:CAB15022" /db_xref="GOA:O34898" /db_xref="InterPro:IPR023264" /db_xref="SubtiList:BG13913" /db_xref="UniProtKB/Swiss-Prot:O34898" /translation="MVDRGLLYREWKQNQVVILLSIAFLVLANPLSIVNTYLSYQGCL DRQDPQYCDFIVNYSISNLIDINWVPGVILAVCFLGMERSKGTMDFILSLPYNRSQIF QTKFWLGGFVIVLSQLIGFLLAWLLILVYNPEHVYFFEHSSIGVIVISFMAFSLVMAA GALTGNAFAQLLTAFSAAILPYLIIALPVGNLEVVFGANIWEIFPSPESYFSLASNLS NLVPISYVVNEWLINSKYLLLIPAVMSMLFYLIGFISFKKLPSERNGHFFLWNRLDRP VQILVMAFGILGFGLFGYYTGHSIIGYILGMIIGAVAGFFVSYFSIYKKTKV*" /label="ytrC CDS" gene complement(2741320..2742306) /gene="ytrC" /locus_tag="BSU_30440" /old_locus_tag="BSU30440" /label="ytrC gene" promotor_-35 2742176..2742185 /Source="Nicolas_upshift_promotors" /id="U2358" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1713 /SigmaFactorBS="aataattcacaataaaatcacaatattgcgggtcttggcgat caAGACACCCTTgataagacaaatACGTATTAACGATAGAaagcggatttgccaatac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2742192 /Source="Nicolas_upshifts" /id="U2358" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1713 /SigmaFactorBS="aataattcacaataaaatcacaatattgcgggtcttggcgat caAGACACCCTTgataagacaaatACGTATTAACGATAGAaagcggatttgccaatac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2742198..2742213 /Source="Nicolas_upshift_promotors" /id="U2358" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1713 /SigmaFactorBS="aataattcacaataaaatcacaatattgcgggtcttggcgat caAGACACCCTTgataagacaaatACGTATTAACGATAGAaagcggatttgccaatac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2742300..2743178) /gene="ytrB" /locus_tag="BSU_30450" /old_locus_tag="BSU30450" /EC_number="3.6.3.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10986249, 22926563" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986249, 22926563; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (ATP-binding protein) involved in resistance to cell wall inhibitors" /protein_id="NP_390923.1" /db_xref="EnsemblGenomes-Gn:BSU30450" /db_xref="EnsemblGenomes-Tr:CAB15023" /db_xref="GOA:O34641" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13912" /db_xref="UniProtKB/Swiss-Prot:O34641" /translation="MIELRQLSKAIDGNQVLKDVSLTIEKGEIFGLLGRNGSGKTTML RLIQQIIFADSGTILFDGVEIKKHPKVKQNIIYMPVQNPFYDKYTYKQLVDILRRIYP KFDVTYANELMNRYEIPETKKYRELSTGLKKQLSLVLSFAARPALILLDEPTDGIDAV TRHDVLQLMVDEVAERDTSILITSHRLEDIERMCNRIGFLEDNSLTNVMDLDELKEEY IKIQMAFDTDVNLAIREQNIPMLDQAGVFYTVLIPKSDEEKKSFLRELKPKVWNELPV NLEEVFIAKFGGKRRW*" /label="ytrB CDS" gene complement(2742300..2743178) /gene="ytrB" /locus_tag="BSU_30450" /old_locus_tag="BSU30450" /label="ytrB gene" CDS complement(2743171..2743563) /gene="ytrA" /locus_tag="BSU_30460" /old_locus_tag="BSU30460" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10986249, 11756427, 17194626, 21856850, 28357385" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986249, 11756427, 17194626, 21856850, 28357385; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (GntR family, cell wall antibiotics)" /protein_id="NP_390924.1" /db_xref="EnsemblGenomes-Gn:BSU30460" /db_xref="EnsemblGenomes-Tr:CAB15024" /db_xref="GOA:O34712" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13911" /db_xref="UniProtKB/Swiss-Prot:O34712" /translation="MIQIDPRSSTPIYEQIIQQMKELCLKGIMKPGDKLPSVRELATI IIANPNTVSKAYKELEREGIIETLRGRGTYISENAKTTLVEGKMTMIKEQLKQLIIDA HYAGVELEKLHEWIKEISADVKGGKKND*" /label="ytrA CDS" gene complement(2743171..2743563) /gene="ytrA" /locus_tag="BSU_30460" /old_locus_tag="BSU30460" /label="ytrA gene" S_feature complement(2743564..2743808) /Source="Nicolas_S_feature" /locus_tag="new_3119240_3119484_c" /HighExp="Cold, Salt, SMMPr, MG 15, M9-tran, G180, M9-exp, M/G, MG 25, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.71885600000000005" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1162" CDS complement(2743597..2743734) /locus_tag="BSU_30466" /old_locus_tag="BSU30466" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 28357385" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_009513999.1" /db_xref="EnsemblGenomes-Gn:BSU30466" /db_xref="EnsemblGenomes-Tr:CCQ48604" /db_xref="GOA:L8ECR1" /db_xref="UniProtKB/TrEMBL:L8ECR1" /translation="MKHKKRNKRNVPMLIAASVIACSFFLVLVMIGFEWQKSIIDHFY L*" /label="conserved protein of unknown function CDS" gene complement(2743597..2743734) /locus_tag="BSU_30466" /old_locus_tag="BSU30466" /label="gene" downshifts 2743732 /Source="Nicolas_upshifts" /id="D1568" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="2.62989" /MaxDrop="3.1332" /score="6.69010243" /energy="-14.4" /TU="NA" /idTUdmin="U2361" /TUdmin="-1254" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2743803..2743822) /Source="Nicolas_upshift_promotors" /id="U2359" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.795204795204795" /psig="0.998001998001998" /xcortree=2536 /SigmaFactorBS="gggtccgtttttttgtaaaaaaaggATTGACTTtgtgagtca aagtATTTATTGTATTAAGTGTACtaattgaagtaatacactatagacactaatataa a" /listShort="S1162, ytrA, ytrB, ytrC, ytrD, ytrE, ytrF, bceR, bceS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2743808) /Source="Nicolas_upshifts" /id="U2359" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.795204795204795" /psig="0.998001998001998" /xcortree=2536 /SigmaFactorBS="gggtccgtttttttgtaaaaaaaggATTGACTTtgtgagtca aagtATTTATTGTATTAAGTGTACtaattgaagtaatacactatagacactaatataa a" /listShort="S1162, ytrA, ytrB, ytrC, ytrD, ytrE, ytrF, bceR, bceS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2743836..2743843) /Source="Nicolas_upshift_promotors" /id="U2359" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.795204795204795" /psig="0.998001998001998" /xcortree=2536 /SigmaFactorBS="gggtccgtttttttgtaaaaaaaggATTGACTTtgtgagtca aagtATTTATTGTATTAAGTGTACtaattgaagtaatacactatagacactaatataa a" /listShort="S1162, ytrA, ytrB, ytrC, ytrD, ytrE, ytrF, bceR, bceS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2743889..2744161) /gene="ytzC" /locus_tag="BSU_30470" /old_locus_tag="BSU30470" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390925.1" /db_xref="EnsemblGenomes-Gn:BSU30470" /db_xref="EnsemblGenomes-Tr:CAB15025" /db_xref="InterPro:IPR019668" /db_xref="SubtiList:BG13937" /db_xref="UniProtKB/Swiss-Prot:O32073" /translation="MATRQSVDEHLQQCMQAYDYAEEQLKIASKQEHYNDQEYSDAQM QLEDAVNALNKLWLSSNDQQREQLYRMRLQLQSLQNNMILQHPLDV*" /label="ytzC CDS" gene complement(2743889..2744161) /gene="ytzC" /locus_tag="BSU_30470" /old_locus_tag="BSU30470" /label="ytzC gene" downshifts complement(2743896) /Source="Nicolas_upshifts" /id="D1569" /incds=0 /nref=1 /ntot=36 /MaxReadThrough="2.96566" /MaxDrop="8.4811" /score="36.3100501" /energy="-14.4" /TU="NA" /idTUdmin="U2360" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2744201..2744212) /Source="Nicolas_upshift_promotors" /id="U2360" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.743256743256743" /psig="0.743256743256743" /xcortree=824 /SigmaFactorBS="agagaacaaatgaatatcgaccataaattactTTATTGAata aagtcagatgaGGCTACAATATGaatgatggatgatttccattaccaagaggaggggt t" /listShort="ytzC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2744205..2744213 /Source="Nicolas_upshift_promotors" /id="U2361" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.724275724275724" /psig="0.724275724275724" /xcortree=1265 /SigmaFactorBS="tgccacagtaacccctcctcttggtaatggaaatcatccatc attcataTTGTAGCCTcatctgactttatTCAATAAAGTAATTTATGGtcgatattca t" /listShort="ytqA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2744205) /Source="Nicolas_upshifts" /id="U2360" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.743256743256743" /psig="0.743256743256743" /xcortree=824 /SigmaFactorBS="agagaacaaatgaatatcgaccataaattactTTATTGAata aagtcagatgaGGCTACAATATGaatgatggatgatttccattaccaagaggaggggt t" /listShort="ytzC" /GFF_Attribute="listLong" /label="upshifts" upshifts 2744216 /Source="Nicolas_upshifts" /id="U2361" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.724275724275724" /psig="0.724275724275724" /xcortree=1265 /SigmaFactorBS="tgccacagtaacccctcctcttggtaatggaaatcatccatc attcataTTGTAGCCTcatctgactttatTCAATAAAGTAATTTATGGtcgatattca t" /listShort="ytqA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2744227..2744233) /Source="Nicolas_upshift_promotors" /id="U2360" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.743256743256743" /psig="0.743256743256743" /xcortree=824 /SigmaFactorBS="agagaacaaatgaatatcgaccataaattactTTATTGAata aagtcagatgaGGCTACAATATGaatgatggatgatttccattaccaagaggaggggt t" /listShort="ytzC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2744227..2744245 /Source="Nicolas_upshift_promotors" /id="U2361" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.724275724275724" /psig="0.724275724275724" /xcortree=1265 /SigmaFactorBS="tgccacagtaacccctcctcttggtaatggaaatcatccatc attcataTTGTAGCCTcatctgactttatTCAATAAAGTAATTTATGGtcgatattca t" /listShort="ytqA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2744256..2744261 /Source="Nicolas_upshift_promotors" /id="U2362" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2496 /SigmaFactorBS="tttattcaataaagtaatttatggtcgatattcaTTTGTTct cttgtgaaatgCGTGCTACAATTTTAGGATGcaatcgtacgcaaggaggcacatgaat t" /listShort="ytqA, ytqB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2744275..2744294 /Source="Nicolas_upshift_promotors" /id="U2362" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2496 /SigmaFactorBS="tttattcaataaagtaatttatggtcgatattcaTTTGTTct cttgtgaaatgCGTGCTACAATTTTAGGATGcaatcgtacgcaaggaggcacatgaat t" /listShort="ytqA, ytqB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2744282 /Source="Nicolas_upshifts" /id="U2362" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2496 /SigmaFactorBS="tttattcaataaagtaatttatggtcgatattcaTTTGTTct cttgtgaaatgCGTGCTACAATTTTAGGATGcaatcgtacgcaaggaggcacatgaat t" /listShort="ytqA, ytqB" /GFF_Attribute="listLong" /label="upshifts" CDS 2744323..2745291 /gene="ytqA" /locus_tag="BSU_30480" /old_locus_tag="BSU30480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10413665; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_390926.1" /db_xref="EnsemblGenomes-Gn:BSU30480" /db_xref="EnsemblGenomes-Tr:CAB15026" /db_xref="GOA:O35008" /db_xref="InterPro:IPR005911" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR032432" /db_xref="SubtiList:BG13908" /db_xref="UniProtKB/Swiss-Prot:O35008" /translation="MMQNNPFPYSNTEKRYHTLNYHLREHFGHKVFKVALDGGFDCPN RDGTVAHGGCTFCSAAGSGDFAGNRTDDLITQFHDIKNRMHEKWKDGKYIAYFQAFTN THAPVEVLREKFESVLALDDVVGISIATRPDCLPDDVVDYLAELNERTYLWVELGLQT VHERTALLINRAHDFNCYVEGVNKLRKHGIRVCSHIINGLPLEDRDMMMETAKAVADL DVQGIKIHLLHLLKGTPMVKQYEKGKLEFLSQDDYVQLVCDQLEIIPPEMIVHRITGD GPIELMIGPMWSVNKWEVLGAINKELENRGSYQGKFFQRLEEESAL*" /label="ytqA CDS" gene 2744323..2745291 /gene="ytqA" /locus_tag="BSU_30480" /old_locus_tag="BSU30480" /label="ytqA gene" CDS 2745288..2745872 /gene="ytqB" /locus_tag="BSU_30490" /old_locus_tag="BSU30490" /EC_number="2.1.1.-" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16014871, 22333191, 24699744; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA methylase" /protein_id="NP_390927.1" /db_xref="EnsemblGenomes-Gn:BSU30490" /db_xref="EnsemblGenomes-Tr:CAB15027" /db_xref="GOA:O34614" /db_xref="InterPro:IPR010719" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG13909" /db_xref="UniProtKB/Swiss-Prot:O34614" /translation="MILKKILPYSKELLKMAAGEGDIVVDATMGNGHDTQFLAELVGE NGHVYAFDIQESAVANTKERLGDMYQARTTLFHKSHDKIAESLPPETHGKVAAAVFNL GYLPGGDKSITTNGSSTIKAIEQLLSIMKDEGLIVLVVYHGHPEGKAEKNDVLEFCRD LDQQTARVLTYGFINQQNDPPFIVAIEKKAQISK*" /label="ytqB CDS" gene 2745288..2745872 /gene="ytqB" /locus_tag="BSU_30490" /old_locus_tag="BSU30490" /label="ytqB gene" downshifts 2745836 /Source="Nicolas_upshifts" /id="D1570" /incds=0 /nref=58 /ntot=249 /MaxReadThrough="2.35311" /MaxDrop="4.47418" /score="22.0352465" /energy="-11.9" /TU="NA" /idTUdmin="U2362" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" CDS complement(2745862..2746965) /gene="tbcS" /locus_tag="BSU_30500" /old_locus_tag="BSU30500" /EC_number="4.2.3.130" /experiment="publication(s) with functional evidences, PMID:21627333, 24806199" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21627333, 24806199; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tetraprenyl-beta-curcumene synthase" /protein_id="NP_390928.1" /db_xref="EnsemblGenomes-Gn:BSU30500" /db_xref="EnsemblGenomes-Tr:CAB15028" /db_xref="GOA:O34707" /db_xref="InterPro:IPR019712" /db_xref="SubtiList:BG13901" /db_xref="UniProtKB/Swiss-Prot:O34707" /translation="MTVPEHPFGLMAKVYRDIFPLVHQELDIWKQKSESIHNSELKAQ ATASIRDKTFHCEGGGILALLSGSQKQKCVEFIIAYQTISDYLDNLCDRSTSLDPQDF RMLHASMQDALTVGAELQNYYQFREEQDDSGYLHELVKTCQRVLGSIEHYDMIKPYLL ELCGYYCDLQVHKHVIEHERVPRLEKWFTQYESELPEMEWYEFSACAGSTLGIFCLVA YSFQPDFTESTAKKIRDSYFPYIQGLHILLDYLIDQEEDLLEGDLNFCSYYQSHEEMM DRLEHFIHKADEHLQGIPHENFHRLINRGLLGVYLSDDKVAGQKEMGRLAKKLIKASG KTSLFFYINGRAYRKFQKMSWMKNSKKKAQIIC*" /label="tbcS CDS" gene complement(2745862..2746965) /gene="tbcS" /locus_tag="BSU_30500" /old_locus_tag="BSU30500" /label="tbcS gene" downshifts complement(2745903) /Source="Nicolas_upshifts" /id="D1571" /incds=0 /nref=35 /ntot=240 /MaxReadThrough="3.47268" /MaxDrop="4.45295" /score="16.7564664" /energy="-10.1" /TU="U2364" /idTUdmin="U2365" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" CDS complement(2746986..2747765) /gene="ytpA" /locus_tag="BSU_30510" /old_locus_tag="BSU30510" /EC_number="3.1.-.-" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11796336" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11796336; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phospholipase component of bacilysocin synthesisor export" /protein_id="NP_390929.1" /db_xref="EnsemblGenomes-Gn:BSU30510" /db_xref="EnsemblGenomes-Tr:CAB15029" /db_xref="GOA:O34705" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR022742" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG13900" /db_xref="UniProtKB/Swiss-Prot:O34705" /translation="MWTWKADRPVAVIVIIHGASEYHGRYKWLIEMWRSSGYHVVMGD LPGQGTTTRARGHIRSFQEYIDEVDAWIDKARTFDLPVFLLGHSMGGLVAIEWVKQQR NPRITGIILSSPCLGLQIKVNKALDLASKGLNVIAPSLKVDSGLSIDMATRNEDVIEA DQNDSLYVRKVSVRWYRELLKTIESAMVPTEAFLKVPLLVMQAGDDKLVDKTMVIKWF NGVASHNKAYREWEGLYHEIFNEPEREDVFKAARAFTDQYI*" /label="ytpA CDS" gene complement(2746986..2747765) /gene="ytpA" /locus_tag="BSU_30510" /old_locus_tag="BSU30510" /label="ytpA gene" promotor_-35 2747408..2747415 /Source="Nicolas_upshift_promotors" /id="U2363" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.632367632367632" /psig="0.962037962037962" /xcortree=2858 /SigmaFactorBS="caagcgctttattcactttaaTTTGCAGTccgagacacggtg aTGATAAAATAATTCCCGTAAtccggggatttctttgctgtttaacccattcaatcgc g" /listShort="ytoA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2747430..2747449 /Source="Nicolas_upshift_promotors" /id="U2363" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.632367632367632" /psig="0.962037962037962" /xcortree=2858 /SigmaFactorBS="caagcgctttattcactttaaTTTGCAGTccgagacacggtg aTGATAAAATAATTCCCGTAAtccggggatttctttgctgtttaacccattcaatcgc g" /listShort="ytoA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2747447 /Source="Nicolas_upshifts" /id="U2363" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.632367632367632" /psig="0.962037962037962" /xcortree=2858 /SigmaFactorBS="caagcgctttattcactttaaTTTGCAGTccgagacacggtg aTGATAAAATAATTCCCGTAAtccggggatttctttgctgtttaacccattcaatcgc g" /listShort="ytoA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2747766..2748345) /Source="Nicolas_S_feature" /locus_tag="new_3123442_3124021_c" /HighExp="dia15, H2O2, Diami, Salt, dia5, M0t90, Lbstat, Etha, Paraq, Lbtran" /AntisenseName="ytoA" /AntisenseCor="-0.44861767737485803" /AntisenseRegPval="-14" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigA" /TUlongPSig=1 /label="S1163" CDS 2747814..2748329 /gene="ytoA" /locus_tag="BSU_30520" /old_locus_tag="BSU30520" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22868757; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme of the carbonic anhydrase family" /protein_id="NP_390930.1" /db_xref="EnsemblGenomes-Gn:BSU30520" /db_xref="EnsemblGenomes-Tr:CAB15030" /db_xref="GOA:O34696" /db_xref="InterPro:IPR001451" /db_xref="InterPro:IPR011004" /db_xref="SubtiList:BG13896" /db_xref="UniProtKB/Swiss-Prot:O34696" /translation="MIYPYKEHKPDIHPTAFIADNATITGDVVIGEQSSIWFSVVIRG DVAPTRIGNRVNIQDLSCLHQSPNKTLLIEDDATIGHQVTLHSAVIRKNALIGMGSII LDGAEIGEGAFIGAGSLVPPGKIIPPGHLAFGRPAKVIRPLTEEDRKDMQRIRSEYVE KGQYYKFLQQT*" /label="ytoA CDS" gene 2747814..2748329 /gene="ytoA" /locus_tag="BSU_30520" /old_locus_tag="BSU30520" /label="ytoA gene" promotor_-10 complement(2748336..2748355) /Source="Nicolas_upshift_promotors" /id="U2364" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.887112887112887" /psig=1 /xcortree=1919 /SigmaFactorBS="gtatgacgtccgggttaacgatggttattgcTTTCAAATata atttgaaaAATGGTAAAGTAAGACGAAGcaggtcttatgtttgttgaagaaatttata a" /listShort="S1163, ytpA, ytpB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2748345) /Source="Nicolas_upshifts" /id="U2364" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.887112887112887" /psig=1 /xcortree=1919 /SigmaFactorBS="gtatgacgtccgggttaacgatggttattgcTTTCAAATata atttgaaaAATGGTAAAGTAAGACGAAGcaggtcttatgtttgttgaagaaatttata a" /listShort="S1163, ytpA, ytpB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2748347..2748481) /Source="Nicolas_S_feature" /locus_tag="new_3124023_3124157_c" /HighExp="LoTm, Cold, dia5, dia15, Diami, H2O2, S7, G135, G180, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1164" promotor_-35 complement(2748367..2748374) /Source="Nicolas_upshift_promotors" /id="U2364" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.887112887112887" /psig=1 /xcortree=1919 /SigmaFactorBS="gtatgacgtccgggttaacgatggttattgcTTTCAAATata atttgaaaAATGGTAAAGTAAGACGAAGcaggtcttatgtttgttgaagaaatttata a" /listShort="S1163, ytpA, ytpB" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(2748456..2748475) /Source="Nicolas_upshift_promotors" /id="U2365" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.968031968031968" /psig="0.998001998001998" /xcortree=1850 /SigmaFactorBS="gtgctcatagaaaatagagaacaggaaagaataggtatgtgt ttttgcagaggctgtttatagtttTGTGATAAGATAAAAGTCATacgtttcatgctat a" /listShort="S1164, S1163, ytpA, ytpB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2748481) /Source="Nicolas_upshifts" /id="U2365" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.968031968031968" /psig="0.998001998001998" /xcortree=1850 /SigmaFactorBS="gtgctcatagaaaatagagaacaggaaagaataggtatgtgt ttttgcagaggctgtttatagtttTGTGATAAGATAAAAGTCATacgtttcatgctat a" /listShort="S1164, S1163, ytpA, ytpB" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2748574..2749965) /gene="ytnA" /locus_tag="BSU_30530" /old_locus_tag="BSU30530" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative amino acid permease" /protein_id="NP_390931.1" /db_xref="EnsemblGenomes-Gn:BSU30530" /db_xref="EnsemblGenomes-Tr:CAB15031" /db_xref="GOA:O34618" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG13891" /db_xref="UniProtKB/Swiss-Prot:O34618" /translation="MQKQKQELHRGLEERHISLMSLGAAIGVGLFLGSASAIQLAGPG ILVAYAASGLVMFFIMRALGEMAIQKPVAGSFSRYARDYLGPLAGYLTGWNYWFLWVV TCMAEITAVGIYMGFWFPDVPNWIWALSALVIMTGVNFLAVKAYGELEFWFALIKIVA ILSMIAVGLLMIIAGVGNGGIATGISNLWNNGGFFPHGLKGVLLSLQMVMFAYLGIEM IGVTAGEVKNPQKSLAKAIDTVFWRILIFYVGALFVIMSIYPWQEIGSQGSPFVLTFQ KVGIPSAAGIINFVVLTAALSSCNSGIFSTGRMLFNLAEQKEAPQAYGQLTKGGIPGK AVLASAGALLVGVLLNYVVPAKVFTWVTSIATFGAIWTWAIILLSQIKYRKSLKPEEK KQLKYKMPLFPFTSYVSLAFLAFVVILMAYSPDTRVAVIIGPIWFLILLAVYYGKGFH KKNAAAASERNIS*" /label="ytnA CDS" gene complement(2748574..2749965) /gene="ytnA" /locus_tag="BSU_30530" /old_locus_tag="BSU30530" /label="ytnA gene" downshifts complement(2748582) /Source="Nicolas_upshifts" /id="D1572" /incds=0 /nref=133 /ntot=225 /MaxReadThrough="3.05784" /MaxDrop="5.43778" /score="3.82664462" /energy="-7.5" /TU="U2368" /idTUdmin="U2368" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" S_feature complement(2749966..2750100) /Source="Nicolas_S_feature" /locus_tag="new_3125642_3125776_c" /HighExp="Oxctl, Paraq, Heat, Lbexp, G150, S0, dia0, H2O2, G180, Mal" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1165" CDS complement(2750101..2751999) /gene="asnB" /locus_tag="BSU_30540" /old_locus_tag="BSU30540" /EC_number="2.4.-.-" /EC_number="6.3.5.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10498721, 21949063, 28317238" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10498721, 21949063, 28317238; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="meso-diaminopimelic acid amidotransferase (asparagine synthetase)" /protein_id="NP_390932.1" /db_xref="EnsemblGenomes-Gn:BSU30540" /db_xref="EnsemblGenomes-Tr:CAB15032" /db_xref="GOA:P54420" /db_xref="InterPro:IPR001962" /db_xref="InterPro:IPR006426" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR017932" /db_xref="InterPro:IPR029055" /db_xref="InterPro:IPR033738" /db_xref="SubtiList:BG11831" /db_xref="UniProtKB/Swiss-Prot:P54420" /translation="MCGFVGVFNKHPLAQTADQEELIKQMNQMIVHRGPDSDGYFHDE HVGFGFRRLSIIDVENGGQPLSYEDETYWIIFNGEIYNYIELREELEAKGYTFNTDSD TEVLLATYRHYKEEAASKLRGMFAFLIWNKNDHVLYGARDPFGIKPLYYTTINDQVYF ASERKSLMVAQNDIEIDKEALQQYMSFQFVPEPSTLDAHVKKVEPGSQFTIRPDGDIT FKTYFKANFKPVQTEEDKLVKEVRDAIYDSVNVHMRSDVPVGSFLSGGIDSSFIVSVA KEFHPSLKTFSVGFEQQGFSEVDVAKETAAALGIENISKVISPEEYMNELPKIVWHFD DPLADPAAIPLYFVAKEAKKHVTVALSGEGADELFGGYNIYREPLSLKPFERIPSGLK KMLLHVAAVMPEGMRGKSLLERGCTPLQDRYIGNAKIFEESVKKQLLKHYNPNLSYRD VTKTYFTESSSYSDINKMQYVDIHTWMRGDILLKADKMTMANSLELRVPFLDKVVFDV ASKIPDELKTKNGTTKYLLRKAAEGIVPEHVLNRKKLGFPVPIRHWLKNEMNEWVRNI IQESQTDAYIHKDYVLQLLEDHCADKADNSRKIWTVLIFMIWHSINIEKRYMPEELSH QPKEVIFV*" /label="asnB CDS" gene complement(2750101..2751999) /gene="asnB" /locus_tag="BSU_30540" /old_locus_tag="BSU30540" /label="asnB gene" promotor_-35 2751157..2751163 /Source="Nicolas_upshift_promotors" /id="U2366" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=950 /SigmaFactorBS="aaagccgacagagaatgtttttaagctTGGATGAaattcctt cgcaacAGACACAATAAAggaagaatcaatcccgccagacaggaacgaaccgacagga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2751178..2751189 /Source="Nicolas_upshift_promotors" /id="U2366" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=950 /SigmaFactorBS="aaagccgacagagaatgtttttaagctTGGATGAaattcctt cgcaacAGACACAATAAAggaagaatcaatcccgccagacaggaacgaaccgacagga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2751190 /Source="Nicolas_upshifts" /id="U2366" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=950 /SigmaFactorBS="aaagccgacagagaatgtttttaagctTGGATGAaattcctt cgcaacAGACACAATAAAggaagaatcaatcccgccagacaggaacgaaccgacagga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2752000..2752123) /Source="Nicolas_S_feature" /locus_tag="new_3127676_3127799_c" /HighExp="Paraq, G135, G180, G150, Oxctl, LBGexp, BMM, dia0, Heat, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigA" /TUshortPSig="0.632, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1166" CDS complement(2752149..2753351) /gene="metK" /locus_tag="BSU_30550" /old_locus_tag="BSU30550" /EC_number="2.5.1.6" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8755891, 10094622, 12910260, 16672621, 18634909" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8755891, 10094622, 12910260, 16672621, 18634909; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="S-adenosylmethionine synthetase" /protein_id="NP_390933.1" /db_xref="EnsemblGenomes-Gn:BSU30550" /db_xref="EnsemblGenomes-Tr:CAB15033" /db_xref="GOA:P54419" /db_xref="InterPro:IPR002133" /db_xref="InterPro:IPR022628" /db_xref="InterPro:IPR022629" /db_xref="InterPro:IPR022630" /db_xref="InterPro:IPR022631" /db_xref="InterPro:IPR022636" /db_xref="SubtiList:BG11840" /db_xref="UniProtKB/Swiss-Prot:P54419" /translation="MSKNRRLFTSESVTEGHPDKICDQISDSILDEILKKDPNARVAC ETSVTTGLVLVSGEITTSTYVDIPKTVRQTIKEIGYTRAKYGFDAETCAVLTSIDEQS ADIAMGVDQALEAREGTMSDEEIEAIGAGDQGLMFGYACNETKELMPLPISLAHKLAR RLSEVRKEDILPYLRPDGKTQVTVEYDENNKPVRIDAIVISTQHHPEITLEQIQRNIK EHVINPVVPEELIDEETKYFINPTGRFVIGGPQGDAGLTGRKIIVDTYGGYARHGGGA FSGKDATKVDRSAAYAARYVAKNIVAAELADSCEVQLAYAIGVAQPVSISINTFGSGK ASEEKLIEVVRNNFDLRPAGIIKMLDLRRPIYKQTAAYGHFGRHDVDLPWERTDKAEQ LRKEALGE*" /label="metK CDS" gene complement(2752149..2753351) /gene="metK" /locus_tag="BSU_30550" /old_locus_tag="BSU30550" /label="metK gene" downshifts complement(2752168) /Source="Nicolas_upshifts" /id="D1573" /incds=0 /nref=2 /ntot=26 /MaxReadThrough="7.14538" /MaxDrop="3.78097" /score="-4.044113" /energy="-12.1" /TU="U2367,U2368" /idTUdmin="U2367" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2753394..2753405) /Source="Nicolas_upshift_promotors" /id="U2367" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.632367632367632" /psig="0.632367632367632" /xcortree=1447 /SigmaFactorBS="tatgccaattaacattctctaatataactgtacatTGTATAA gagggagcgagttCCGTATCATATAtacaaggtctttcgggaggccttgtgcaggagg a" /listShort="metK, S1166" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2753400) /Source="Nicolas_upshifts" /id="U2367" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.632367632367632" /psig="0.632367632367632" /xcortree=1447 /SigmaFactorBS="tatgccaattaacattctctaatataactgtacatTGTATAA gagggagcgagttCCGTATCATATAtacaaggtctttcgggaggccttgtgcaggagg a" /listShort="metK, S1166" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2753402..2753518) /Source="Nicolas_S_feature" /locus_tag="new_3129078_3129194_c" /HighExp="G180, Paraq, G150, Oxctl, G135, BMM, LBGexp, HPh, MG-0.2, GM 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1167" promotor_-35 complement(2753419..2753425) /Source="Nicolas_upshift_promotors" /id="U2367" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.632367632367632" /psig="0.632367632367632" /xcortree=1447 /SigmaFactorBS="tatgccaattaacattctctaatataactgtacatTGTATAA gagggagcgagttCCGTATCATATAtacaaggtctttcgggaggccttgtgcaggagg a" /listShort="metK, S1166" /GFF_Attribute="listLong" /label="promotor_-35" misc_RNA complement(2753519..2753657) /gene="mswG" /locus_tag="BSU_misc_RNA_50" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /function="16.3: Control" /label="mswG RNA" gene complement(2753519..2753657) /gene="mswG" /locus_tag="BSU_misc_RNA_50" /label="mswG gene" downshifts 2753617 /Source="Nicolas_upshifts" /id="D1574" /incds=0 /nref=3 /ntot=20 /MaxReadThrough="1.15866" /MaxDrop="4.97875" /score="11.8729615" /energy="-16.6" /TU="NA" /idTUdmin="U2369" /TUdmin="-1841" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2753666..2753685) /Source="Nicolas_upshift_promotors" /id="U2368" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.624375624375624" /psig=1 /xcortree=2593 /SigmaFactorBS="ttccctcaatataggtgcctatttcttctgaatcaTATTGac attgcaaaccctttTACGATAAGATATTTCATTGagcggatactcttatcccgagctg g" /listShort="NA, S1167, metK, S1166, asnB, S1165, ytnA, S1164" /listLong="S1163, ytpA, ytpB" /label="promotor_-10" upshifts complement(2753681) /Source="Nicolas_upshifts" /id="U2368" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.624375624375624" /psig=1 /xcortree=2593 /SigmaFactorBS="ttccctcaatataggtgcctatttcttctgaatcaTATTGac attgcaaaccctttTACGATAAGATATTTCATTGagcggatactcttatcccgagctg g" /listShort="NA, S1167, metK, S1166, asnB, S1165, ytnA, S1164" /listLong="S1163, ytpA, ytpB" /label="upshifts" promotor_-35 complement(2753702..2753706) /Source="Nicolas_upshift_promotors" /id="U2368" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.624375624375624" /psig=1 /xcortree=2593 /SigmaFactorBS="ttccctcaatataggtgcctatttcttctgaatcaTATTGac attgcaaaccctttTACGATAAGATATTTCATTGagcggatactcttatcccgagctg g" /listShort="NA, S1167, metK, S1166, asnB, S1165, ytnA, S1164" /listLong="S1163, ytpA, ytpB" /label="promotor_-35" promotor_-35 2753778..2753785 /Source="Nicolas_upshift_promotors" /id="U2369" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.817182817182817" /psig=1 /xcortree=345 /SigmaFactorBS="gggaaaacaatggaaatgcacacacaaaaaacaataaatagT ATAGACTatttgaaaatataTGTTATACTAATTCACAATTagcaaaacacaaaaaacg a" /listShort="pckA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2753797 /Source="Nicolas_upshifts" /id="U2369" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.817182817182817" /psig=1 /xcortree=345 /SigmaFactorBS="gggaaaacaatggaaatgcacacacaaaaaacaataaatagT ATAGACTatttgaaaatataTGTTATACTAATTCACAATTagcaaaacacaaaaaacg a" /listShort="pckA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2753799..2753818 /Source="Nicolas_upshift_promotors" /id="U2369" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.817182817182817" /psig=1 /xcortree=345 /SigmaFactorBS="gggaaaacaatggaaatgcacacacaaaaaacaataaatagT ATAGACTatttgaaaatataTGTTATACTAATTCACAATTagcaaaacacaaaaaacg a" /listShort="pckA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2753854..2755437 /gene="pckA" /locus_tag="BSU_30560" /old_locus_tag="BSU30560" /EC_number="4.1.1.49" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1400158, 4146915, 15491857, 15720552, 18586936, 20933603, 23136871; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoenolpyruvate carboxykinase" /protein_id="NP_390934.2" /db_xref="EnsemblGenomes-Gn:BSU30560" /db_xref="EnsemblGenomes-Tr:CAB15034" /db_xref="GOA:P54418" /db_xref="InterPro:IPR001272" /db_xref="InterPro:IPR008210" /db_xref="InterPro:IPR013035" /db_xref="InterPro:IPR015994" /db_xref="SubtiList:BG11841" /db_xref="UniProtKB/Swiss-Prot:P54418" /translation="MNSVDLTADLQALLTCPNVRHNLSAAQLTEKVLSRNEGILTSTG AVRATTGAYTGRSPKDKFIVEEESTKNKIDWGPVNQPISEEAFERLYTKVVSYLKERD ELFVFEGFAGADEKYRLPITVVNEFAWHNLFARQLFIRPEGNDKKTVEQPFTILSAPH FKADPKTDGTHSETFIIVSFEKRTILIGGTEYAGEMKKSIFSIMNFLLPERDILSMHC SANVGEKGDVALFFGLSGTGKTTLSADADRKLIGDDEHGWSDTGVFNIEGGCYAKCIH LSEEKEPQIFNAIRFGSVLENVVVDEDTREANYDDSFYTENTRAAYPIHMINNIVTPS MAGHPSAIVFLTADAFGVLPPISKLTKEQAMYHFLSGYTSKLAGTERGVTSPETTFST CFGSPFLPLPAHVYAEMLGKKIDEHGADVFLVNTGWTGGGYGTGERMKLSYTRAMVKA AIEGKLEDAEMITDDIFGLHIPAHVPGVPDHILQPENTWTNKEEYKEKAVYLANEFKE NFKKFAHTDAIAQAGGPLV*" /label="pckA CDS" gene 2753854..2755437 /gene="pckA" /locus_tag="BSU_30560" /old_locus_tag="BSU30560" /label="pckA gene" downshifts 2755426 /Source="Nicolas_upshifts" /id="D1575" /incds=0 /nref=106 /ntot=269 /MaxReadThrough="2.55056" /MaxDrop="8.3695" /score="11.8729615" /energy="-16.6" /TU="U2369" /idTUdmin="U2369" /TUdmin="-32" /isTUend="FALSE" /label="downshifts" CDS complement(2755476..2755718) /gene="ytmB" /locus_tag="BSU_30570" /old_locus_tag="BSU30570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390935.1" /db_xref="EnsemblGenomes-Gn:BSU30570" /db_xref="EnsemblGenomes-Tr:CAB15035" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR019699" /db_xref="PDB:2NWA" /db_xref="SubtiList:BG13882" /db_xref="UniProtKB/Swiss-Prot:O34365" /translation="MGMPVEFNTLIVTKGKEVRIDENIFTLEKDGYRVYPMEIPMDVR KTKFGEKSGTAEVQKLQWEEGRTIITYKLTSLHSVN*" /label="ytmB CDS" gene complement(2755476..2755718) /gene="ytmB" /locus_tag="BSU_30570" /old_locus_tag="BSU30570" /label="ytmB gene" downshifts complement(2755490) /Source="Nicolas_upshifts" /id="D1576" /incds=0 /nref=170 /ntot=242 /MaxReadThrough="1.2088" /MaxDrop="5.1365" /score="38.3436505" /energy="-16.6" /TU="NA" /idTUdmin="U2371" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2755770..2756543) /gene="ytmA" /locus_tag="BSU_30580" /old_locus_tag="BSU30580" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 27899916; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative esterase" /protein_id="NP_390936.1" /db_xref="EnsemblGenomes-Gn:BSU30580" /db_xref="EnsemblGenomes-Tr:CAB15036" /db_xref="GOA:O34493" /db_xref="InterPro:IPR001375" /db_xref="InterPro:IPR002471" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG13881" /db_xref="UniProtKB/Swiss-Prot:O34493" /translation="MIVEKRRFPSPSQHVRLYTICYLSNGLRVKGLLAEPAEPGQYDG FLYLRGGIKSVGMVRPGRIIQFASQGFVVFAPFYRGNQGGEGNEDFAGEDREDAFSAF RLLQQHPNVKKDRIHIFGFSRGGIMGMLTAIEMGGQAASFVSWGGVSDMILTYEERQD LRRMMKRVIGGTPKKVPEEYQWRTPFDQVNKIQAPVLLIHGEKDQNVSIQHSYLLEEK LKQLHKPVETWYYSTFTHYFPPKENRRIVRQLTQWMKNR*" /label="ytmA CDS" gene complement(2755770..2756543) /gene="ytmA" /locus_tag="BSU_30580" /old_locus_tag="BSU30580" /label="ytmA gene" S_feature complement(2756544..2756634) /Source="Nicolas_S_feature" /locus_tag="new_3132220_3132310_c" /HighExp="S8, dia15, Diami, Etha, S7, dia5, H2O2, G180, Heat, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1168" promotor_-35 2756610..2756619 /Source="Nicolas_upshift_promotors" /id="U2370" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1294 /SigmaFactorBS="tttccttactccaaaattacatccggagaacctggttagGCA TTCACACatttttatacccATCATACGATATGTAAAGCAaaaaaggatattaacttga t" /listShort="ytlA, ytlC, ytlD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2756623..2756642) /Source="Nicolas_upshift_promotors" /id="U2371" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.79020979020979" /psig="0.996003996003996" /xcortree=2027 /SigmaFactorBS="cacatagacaacctccttatttcgcatcaagtTAATATCCtt ttttgctttacaTATCGTATGATGGGTATAAAaatgtgtgaatgcctaaccaggttct c" /listShort="S1168, ytmA, ytmB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2756631 /Source="Nicolas_upshifts" /id="U2370" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1294 /SigmaFactorBS="tttccttactccaaaattacatccggagaacctggttagGCA TTCACACatttttatacccATCATACGATATGTAAAGCAaaaaaggatattaacttga t" /listShort="ytlA, ytlC, ytlD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2756632..2756651 /Source="Nicolas_upshift_promotors" /id="U2370" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1294 /SigmaFactorBS="tttccttactccaaaattacatccggagaacctggttagGCA TTCACACatttttatacccATCATACGATATGTAAAGCAaaaaaggatattaacttga t" /listShort="ytlA, ytlC, ytlD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2756636) /Source="Nicolas_upshifts" /id="U2371" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.79020979020979" /psig="0.996003996003996" /xcortree=2027 /SigmaFactorBS="cacatagacaacctccttatttcgcatcaagtTAATATCCtt ttttgctttacaTATCGTATGATGGGTATAAAaatgtgtgaatgcctaaccaggttct c" /listShort="S1168, ytmA, ytmB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2756657..2756664) /Source="Nicolas_upshift_promotors" /id="U2371" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.79020979020979" /psig="0.996003996003996" /xcortree=2027 /SigmaFactorBS="cacatagacaacctccttatttcgcatcaagtTAATATCCtt ttttgctttacaTATCGTATGATGGGTATAAAaatgtgtgaatgcctaaccaggttct c" /listShort="S1168, ytmA, ytmB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2756694..2757698 /gene="ytlA" /locus_tag="BSU_30595" /old_locus_tag="BSU30595" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC anion transporter component" /protein_id="NP_390937.2" /db_xref="EnsemblGenomes-Gn:BSU30595" /db_xref="EnsemblGenomes-Tr:CAB15037" /db_xref="GOA:C0SP84" /db_xref="SubtiList:BG13873" /db_xref="UniProtKB/Swiss-Prot:C0SP84" /translation="MNRWLRLGFACVGSIFLMFALAACKQEETLTKVKVAEVTHSIFY APLYVAESKGFFKEEGLDVDVNTTWGGDKTMTSLLSNGSDIALVGSETSIYVEAQGAK DPVINFAQLTQTDGTFLVAREDVEHFDWDQLKGKTFLGQRKGGMPQMVGEYVLNKHKI DPHKDIDLIQNIDFANIANAFASGTGEYVQLFEPQASLFEKKGIGHIVASFGEESGEV PYTTFMAKQSYLKKNEDTAVKFTKAIYKAQQWVENHSAKDITDAIKDEFDDTDPDVIE TSIERYKKQHSYSPDPLLNEKEWELLQTIMDKSGELPKHIPYNQLVNKEIAEKVTSEK *" /label="ytlA CDS" gene 2756694..2757698 /gene="ytlA" /locus_tag="BSU_30595" /old_locus_tag="BSU30595" /label="ytlA gene" CDS 2757711..2758493 /gene="ytlC" /locus_tag="BSU_30610" /old_locus_tag="BSU30610" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC anion transporter component, ATP-binding" /protein_id="NP_390939.1" /db_xref="EnsemblGenomes-Gn:BSU30610" /db_xref="EnsemblGenomes-Tr:CAB15039" /db_xref="GOA:O34314" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13875" /db_xref="UniProtKB/Swiss-Prot:O34314" /translation="MSFLHVDHVTHTYFSIKEKTTAVRDIHFDAEKGDFISFLGPSGC GKTTLLSIIAGLIEPSEGRVLIEGREPNQKEHNIGYMLQQDYLFPWKSIEENVLLGLK IADTLTEESKAAALGLLPEFGLIDVEKKYPKELSGGMRQRAALARTLAPNPSLLLLDE PFSALDFQTKLSLENLVFRTLKEYQKTAVLVTHDIGEAIAMSDTIFLFSNQPGTIHQI FTIPKELAAMLPFDARQEPSFQTLFQTIWKELNSLEKQQRNH*" /label="ytlC CDS" gene 2757711..2758493 /gene="ytlC" /locus_tag="BSU_30610" /old_locus_tag="BSU30610" /label="ytlC gene" S_feature complement(2757715..2759263) /Source="Nicolas_S_feature" /locus_tag="new_3133391_3134939_c" /HighExp="Cold, S8, G180, H2O2, G135, Paraq, G150, S7, Oxctl, LPh" /AntisenseName="ytlC" /AntisenseCor="0.110169300738282" /AntisenseRegPval="-1.1000000000000001" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1169" CDS 2758468..2759280 /gene="ytlD" /locus_tag="BSU_30620" /old_locus_tag="BSU30620" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease of ABC anion transporter" /protein_id="NP_390940.1" /db_xref="EnsemblGenomes-Gn:BSU30620" /db_xref="EnsemblGenomes-Tr:CAB15040" /db_xref="GOA:O34649" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG13876" /db_xref="UniProtKB/Swiss-Prot:O34649" /translation="MRNSKETIDLLHEQYQFKQKKEKWKVHSFQLAIFILFFSGWEIS SRQGWIDPLIFSSPSAVWRLLLEKLGDGSLLSHIGVTLFETVLGFLLGTFMGTCLAAL LWWSNRLARILDPYLVILNAMPKVALGPILIVALGPSFISIIAMGAIISVIITTIVVY TAFQEVDENYTKVMKTFGAKKWVIFKEVILPASSPAIISTLKVNVGLSWVGVIVGEFL VSKVGLGYMIIYGFQVFNFTLVFLSLLIIAIFATLMYQGVELLEKKWTKGRT*" /label="ytlD CDS" gene 2758468..2759280 /gene="ytlD" /locus_tag="BSU_30620" /old_locus_tag="BSU30620" /label="ytlD gene" downshifts 2759265 /Source="Nicolas_upshifts" /id="D1577" /incds=0 /nref=1 /ntot=31 /MaxReadThrough="3.58734" /MaxDrop="4.596" /score="38.1379668" /energy="-12.6" /TU="U2370" /idTUdmin="U2370" /TUdmin="-242" /isTUend="FALSE" /label="downshifts" CDS complement(2759307..2759783) /gene="rppG" /locus_tag="BSU_30630" /old_locus_tag="BSU30630" /EC_number="3.6.1.15" /function="16.6: Maintain" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15576788, 16513759, 21925382, 23610407, 23610425, 27936487" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15576788, 16513759, 21925382, 23610407, 23610425, 27936487; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="nucleoside and RNA triphosphate phosphohydrolase" /protein_id="NP_390941.1" /db_xref="EnsemblGenomes-Gn:BSU30630" /db_xref="EnsemblGenomes-Tr:CAB15041" /db_xref="GOA:O35013" /db_xref="InterPro:IPR000086" /db_xref="InterPro:IPR014078" /db_xref="InterPro:IPR015797" /db_xref="InterPro:IPR020084" /db_xref="InterPro:IPR020476" /db_xref="PDB:4JZS" /db_xref="PDB:4JZT" /db_xref="PDB:4JZU" /db_xref="PDB:4JZV" /db_xref="SubtiList:BG13869" /db_xref="UniProtKB/Swiss-Prot:O35013" /translation="MYEFKDYYQNTVQLSFDDQPFSDSPKHVWVICRFGGKWLLTEHE DRGYEFPGGKVEPMECAEEAALREVKEETGARVKSLKYLGQYKVLGKEKVIVKNIYFA DIEKLEKQADYFETKGPVLFHELPENLSRNKKFSFIMKDSVLPISLKKLKESGWIE*" /label="rppG CDS" gene complement(2759307..2759783) /gene="rppG" /locus_tag="BSU_30630" /old_locus_tag="BSU30630" /label="rppG gene" downshifts complement(2759308) /Source="Nicolas_upshifts" /id="D1578" /incds=0 /nref=171 /ntot=265 /MaxReadThrough="4.52721" /MaxDrop="6.99686" /score="36.2618206" /energy="-12.6" /TU="U2372" /idTUdmin="U2373" /TUdmin=11 /isTUend="TRUE" /label="downshifts" misc_feature complement(2759813..2759832) /Source="Nicolas_upshift_promotors" /id="U2372" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.935064935064935" /psig=1 /xcortree=2134 /SigmaFactorBS="cggcgtgctgggtttcccttattttttgataaaaggcttccg aagaaacgtaacTGTGGTATGATGTATGGAAGatagctaggaacggatttgagggata a" /listShort="ytkD, S1169" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2759826) /Source="Nicolas_upshifts" /id="U2372" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.935064935064935" /psig=1 /xcortree=2134 /SigmaFactorBS="cggcgtgctgggtttcccttattttttgataaaaggcttccg aagaaacgtaacTGTGGTATGATGTATGGAAGatagctaggaacggatttgagggata a" /listShort="ytkD, S1169" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2759828..2759962) /Source="Nicolas_S_feature" /locus_tag="new_3135504_3135638_c" /HighExp="BT, B36, S8, S5, S7, Etha, S6, S4, B60, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigK, SigB" /TUshortPSig="0.909, 1, 0.994" /TUlongSig="SigA, SigA" /TUlongPSig="0.999, 0.994" /label="S1170" upshifts complement(2759962) /Source="Nicolas_upshifts" /id="U2373" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.909090909090909" /psig="0.909090909090909" /xcortree=1213 /SigmaFactorBS="gttaaaaaataaatttaagcgcaaacCGTAACTtttccctgt tcgcgGGTCATAATAAAgcccagagcgtcggtcgcactttccggcaaaagtatcgcaa a" /listShort="S1170, ytkD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2759964..2759975) /Source="Nicolas_upshift_promotors" /id="U2373" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.909090909090909" /psig="0.909090909090909" /xcortree=1213 /SigmaFactorBS="gttaaaaaataaatttaagcgcaaacCGTAACTtttccctgt tcgcgGGTCATAATAAAgcccagagcgtcggtcgcactttccggcaaaagtatcgcaa a" /listShort="S1170, ytkD" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2759990..2759996) /Source="Nicolas_upshift_promotors" /id="U2373" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.909090909090909" /psig="0.909090909090909" /xcortree=1213 /SigmaFactorBS="gttaaaaaataaatttaagcgcaaacCGTAACTtttccctgt tcgcgGGTCATAATAAAgcccagagcgtcggtcgcactttccggcaaaagtatcgcaa a" /listShort="S1170, ytkD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2759992..2760396) /gene="ytkC" /locus_tag="BSU_30640" /old_locus_tag="BSU30640" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative autolytic amidase" /protein_id="NP_390942.1" /db_xref="EnsemblGenomes-Gn:BSU30640" /db_xref="EnsemblGenomes-Tr:CAB15042" /db_xref="GOA:O34883" /db_xref="InterPro:IPR006480" /db_xref="SubtiList:BG13868" /db_xref="UniProtKB/Swiss-Prot:O34883" /translation="MDRDFGIFSFLAVSVSAAGFFFGGFQYSFLILLSLMAIEFISTT LKETIIHKLSFKKVFARLVKKLVTLALISVCHFFDQLLNTQGSIRDLAIMFYILYESV QIVVTASSLGIPVPQMLVDLLETLKNKFKRKP*" /label="ytkC CDS" gene complement(2759992..2760396) /gene="ytkC" /locus_tag="BSU_30640" /old_locus_tag="BSU30640" /label="ytkC gene" promotor_-10 complement(2760424..2760443) /Source="Nicolas_upshift_promotors" /id="U2374" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1424 /SigmaFactorBS="gaaaaataggcgacaaccagtccatttttctgaaaaATCCAA TCCGttcggcttgtttACCATAGAATATCGTAAGGCcgtttctgtgaaaggatgttgg g" /listShort="ytkC, S1170, ytkD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2760441) /Source="Nicolas_upshifts" /id="U2374" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1424 /SigmaFactorBS="gaaaaataggcgacaaccagtccatttttctgaaaaATCCAA TCCGttcggcttgtttACCATAGAATATCGTAAGGCcgtttctgtgaaaggatgttgg g" /listShort="ytkC, S1170, ytkD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2760443..2760529) /Source="Nicolas_S_feature" /locus_tag="new_3136119_3136205_c" /HighExp="Etha, B36, S8, B60, S7, LoTm, Salt, Sw, Gly, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.994" /TUlongSig="SigA, SigA" /TUlongPSig="0.999, 0.994" /label="S1171" promotor_-35 complement(2760456..2760465) /Source="Nicolas_upshift_promotors" /id="U2374" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1424 /SigmaFactorBS="gaaaaataggcgacaaccagtccatttttctgaaaaATCCAA TCCGttcggcttgtttACCATAGAATATCGTAAGGCcgtttctgtgaaaggatgttgg g" /listShort="ytkC, S1170, ytkD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2760562..2760999) /gene="dps" /locus_tag="BSU_30650" /old_locus_tag="BSU30650" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 12767829, 16091047, 16861227, 16935006; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA-protecting protein, mini-ferritin" /protein_id="NP_390943.1" /db_xref="EnsemblGenomes-Gn:BSU30650" /db_xref="EnsemblGenomes-Tr:CAB15043" /db_xref="GOA:P80879" /db_xref="InterPro:IPR002177" /db_xref="InterPro:IPR008331" /db_xref="InterPro:IPR009078" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR023188" /db_xref="SubtiList:BG12584" /db_xref="UniProtKB/Swiss-Prot:P80879" /translation="MSEQLIQAVNKQVANWTVMYVKLHNYHWYVKGKDFFTLHEKFEE LYNETATYIDDLAERLLALNGKPIATMKESLETASVKEAAGNETAEQMVQSVYDDFTV IAEELKNGMDLADEVGDETTGDMLLAIHQNIEKHNWMLKAYLG*" /label="dps CDS" gene complement(2760562..2760999) /gene="dps" /locus_tag="BSU_30650" /old_locus_tag="BSU30650" /label="dps gene" downshifts complement(2760574) /Source="Nicolas_upshifts" /id="D1579" /incds=0 /nref=188 /ntot=382 /MaxReadThrough="3.87056" /MaxDrop="7.83664" /score="36.0931083" /energy="-19.2" /TU="U2375" /idTUdmin="U2377" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2761016..2761034) /Source="Nicolas_upshift_promotors" /id="U2375" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=143 /SigmaFactorBS="cataatagaagaaatcgtgacagataagggtaaaaaagaGGT TTTAgcgtacgatattaaGGGTATACATAGTCATATAacaaggaggagataccatgtc a" /listShort="dps, S1171, ytkC, S1170, ytkD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2761034) /Source="Nicolas_upshifts" /id="U2375" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=143 /SigmaFactorBS="cataatagaagaaatcgtgacagataagggtaaaaaagaGGT TTTAgcgtacgatattaaGGGTATACATAGTCATATAacaaggaggagataccatgtc a" /listShort="dps, S1171, ytkC, S1170, ytkD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2761036..2761261) /Source="Nicolas_S_feature" /locus_tag="new_3136712_3136937_c" /HighExp="M0t90, Lbstat, M40t90, ferm, S2, nit, M40t45, S0, Lbtran, BT" /AntisenseName="ytzI" /AntisenseCor="-0.30531150128448598" /AntisenseRegPval="-6.5" /CDS_PredictionProba="0.38276900000000003" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.999, 0.999, 0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S1172" promotor_-35 complement(2761049..2761055) /Source="Nicolas_upshift_promotors" /id="U2375" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=143 /SigmaFactorBS="cataatagaagaaatcgtgacagataagggtaaaaaagaGGT TTTAgcgtacgatattaaGGGTATACATAGTCATATAacaaggaggagataccatgtc a" /listShort="dps, S1171, ytkC, S1170, ytkD" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 2761091..2761110 /Source="Nicolas_upshift_promotors" /id="U2376" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.94005994005994" /psig="0.999000999001" /xcortree=436 /SigmaFactorBS="ccttaatatcgtacgctaaaacctcttttttacccttatctg tcacgatttcttctatTATGCTACAATTGTTAAAAAacgggaggtggaatgtcatgac g" /listShort="ytzI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 2761092..2761268 /gene="ytzI" /locus_tag="BSU_30659" /old_locus_tag="BSU30659" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097774.1" /db_xref="EnsemblGenomes-Gn:BSU30659" /db_xref="EnsemblGenomes-Tr:CAX52680" /db_xref="GOA:C0H3Q1" /db_xref="InterPro:IPR022248" /db_xref="UniProtKB/Swiss-Prot:C0H3Q1" /translation="MLQLLKNGRWNVMTLLITISILIVLAVLLVTIWTTVKAYNVKHT IDPPQENHSDSHNQ*" /label="ytzI CDS" gene 2761092..2761268 /gene="ytzI" /locus_tag="BSU_30659" /old_locus_tag="BSU30659" /label="ytzI gene" upshifts 2761093 /Source="Nicolas_upshifts" /id="U2376" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.94005994005994" /psig="0.999000999001" /xcortree=436 /SigmaFactorBS="ccttaatatcgtacgctaaaacctcttttttacccttatctg tcacgatttcttctatTATGCTACAATTGTTAAAAAacgggaggtggaatgtcatgac g" /listShort="ytzI" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2761262..2761699) /gene="ytkA" /locus_tag="BSU_30660" /old_locus_tag="BSU30660" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_390944.1" /db_xref="EnsemblGenomes-Gn:BSU30660" /db_xref="EnsemblGenomes-Tr:CAB15044" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR032693" /db_xref="SubtiList:BG11027" /db_xref="UniProtKB/Swiss-Prot:P40768" /translation="MKKMLVVLLFSALLLNGCGSGESKANTAETPEVLDVKLTGPEKV NPGESAAYEAAVSYGDEAVTDADEVEFEVWKEGEKDASQMFKVKQEKGVYRLETTFKE DGVYTVQSHVTAKKQHSMPTLKVQVGDADAASNQSEEEHSHHH*" /label="ytkA CDS" gene complement(2761262..2761699) /gene="ytkA" /locus_tag="BSU_30660" /old_locus_tag="BSU30660" /label="ytkA gene" downshifts 2761288 /Source="Nicolas_upshifts" /id="D1580" /incds=0 /nref=37 /ntot=155 /MaxReadThrough="2.0116" /MaxDrop="3.95427" /score="13.1411485" /energy="-20.5" /TU="NA" /idTUdmin="U2376" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2761718..2761737) /Source="Nicolas_upshift_promotors" /id="U2377" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=1608 /SigmaFactorBS="cgcttaagcaaaaaggtcttttttgtgacgtctcatattttg tGTACCATTTgctgtaagcgTTTGCTACTATTTAGGTAAAcgatgaaagggtgatggc a" /listShort="ytkA, S1172, dps" /listLong="S1171, ytkC, S1170, ytkD" /label="promotor_-10" upshifts complement(2761739) /Source="Nicolas_upshifts" /id="U2377" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=1608 /SigmaFactorBS="cgcttaagcaaaaaggtcttttttgtgacgtctcatattttg tGTACCATTTgctgtaagcgTTTGCTACTATTTAGGTAAAcgatgaaagggtgatggc a" /listShort="ytkA, S1172, dps" /listLong="S1171, ytkC, S1170, ytkD" /label="upshifts" promotor_-35 complement(2761748..2761756) /Source="Nicolas_upshift_promotors" /id="U2377" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=1608 /SigmaFactorBS="cgcttaagcaaaaaggtcttttttgtgacgtctcatattttg tGTACCATTTgctgtaagcgTTTGCTACTATTTAGGTAAAcgatgaaagggtgatggc a" /listShort="ytkA, S1172, dps" /listLong="S1171, ytkC, S1170, ytkD" /label="promotor_-35" CDS complement(2761819..2762292) /gene="luxS" /locus_tag="BSU_30670" /old_locus_tag="BSU30670" /EC_number="4.4.1.21" /function="16.5: Explore" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11601850, 15287744, 15751951, 16740951, 17056751, 22720735, 22938038, 26779171, 28342077" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11601850, 15287744, 15751951, 16740951, 17056751, 22720735, 22938038, 26779171, 28342077; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="S-ribosylhomocysteine lyase" /protein_id="NP_390945.1" /db_xref="EnsemblGenomes-Gn:BSU30670" /db_xref="EnsemblGenomes-Tr:CAB15045" /db_xref="GOA:O34667" /db_xref="InterPro:IPR003815" /db_xref="InterPro:IPR011249" /db_xref="InterPro:IPR037005" /db_xref="PDB:1IE0" /db_xref="PDB:1J98" /db_xref="PDB:1JQW" /db_xref="PDB:1JVI" /db_xref="PDB:1YCL" /db_xref="PDB:2FQO" /db_xref="PDB:2FQT" /db_xref="SubtiList:BG13866" /db_xref="UniProtKB/Swiss-Prot:O34667" /translation="MPSVESFELDHNAVVAPYVRHCGVHKVGTDGVVNKFDIRFCQPN KQAMKPDTIHTLEHLLAFTIRSHAEKYDHFDIIDISPMGCQTGYYLVVSGEPTSAEIV DLLEDTMKEAVEITEIPAANEKQCGQAKLHDLEGAKRLMRFWLSQDKEELLKVFG*" /label="luxS CDS" gene complement(2761819..2762292) /gene="luxS" /locus_tag="BSU_30670" /old_locus_tag="BSU30670" /label="luxS gene" downshifts complement(2761828) /Source="Nicolas_upshifts" /id="D1581" /incds=0 /nref=72 /ntot=201 /MaxReadThrough="4.53626" /MaxDrop="4.63695" /score="14.8438415" /energy="-14.2" /TU="U2379,U2380" /idTUdmin="U2380" /TUdmin="-793" /isTUend="FALSE" /label="downshifts" downshifts complement(2761915) /Source="Nicolas_upshifts" /id="D1582" /incds=1 /nref=1 /ntot=96 /MaxReadThrough="5.57623" /MaxDrop="2.4806" /score="14.8438415" /energy="-14.2" /TU="U2379,U2380" /idTUdmin="U2380" /TUdmin="-880" /isTUend="FALSE" /label="downshifts" S_feature complement(2762293..2762644) /Source="Nicolas_S_feature" /locus_tag="new_3137969_3138320_c" /HighExp="Etha, B36, B60, BMM, S2, Heat, S1, LoTm, Lbtran, S5" /AntisenseName="ytjA" /AntisenseCor="-0.45038987072908898" /AntisenseRegPval="-14.1" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S1173" promotor_-35 2762364..2762371 /Source="Nicolas_upshift_promotors" /id="U2378" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.553446553446553" /psig="0.999000999001" /xcortree=2863 /SigmaFactorBS="ttataacatacttttccgataagaattattgattaACTTTTC AatctgtgtttttTTTCTTATACTTGCATCAGAaaggttgctgaagaaacatgaaaac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2762384..2762403 /Source="Nicolas_upshift_promotors" /id="U2378" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.553446553446553" /psig="0.999000999001" /xcortree=2863 /SigmaFactorBS="ttataacatacttttccgataagaattattgattaACTTTTC AatctgtgtttttTTTCTTATACTTGCATCAGAaaggttgctgaagaaacatgaaaac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2762389 /Source="Nicolas_upshifts" /id="U2378" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.553446553446553" /psig="0.999000999001" /xcortree=2863 /SigmaFactorBS="ttataacatacttttccgataagaattattgattaACTTTTC AatctgtgtttttTTTCTTATACTTGCATCAGAaaggttgctgaagaaacatgaaaac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 2762421..2762648 /gene="ytjA" /locus_tag="BSU_30680" /old_locus_tag="BSU30680" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 19306042, 21803992; Product type f: factor" /codon_start=1 /transl_table=11 /product="membrane protein insertion efficiency factor" /protein_id="NP_390946.1" /db_xref="EnsemblGenomes-Gn:BSU30680" /db_xref="EnsemblGenomes-Tr:CAB15046" /db_xref="GOA:O34601" /db_xref="InterPro:IPR002696" /db_xref="SubtiList:BG13865" /db_xref="UniProtKB/Swiss-Prot:O34601" /translation="MKTLFIALIRGYQKFISPLTPPTCRFYPTCSQYGIEAIKTHGAL KGGWLTIKRILKCHPFHPGGVDPVPEKKQKH*" /label="ytjA CDS" gene 2762421..2762648 /gene="ytjA" /locus_tag="BSU_30680" /old_locus_tag="BSU30680" /label="ytjA gene" CDS complement(2762645..2763208) /gene="ytiB" /locus_tag="BSU_30690" /old_locus_tag="BSU30690" /EC_number="4.2.1.1" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12193617, 21266987; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="carbonic anhydrase" /protein_id="NP_390947.1" /db_xref="EnsemblGenomes-Gn:BSU30690" /db_xref="EnsemblGenomes-Tr:CAB15047" /db_xref="GOA:O34872" /db_xref="InterPro:IPR001765" /db_xref="InterPro:IPR036874" /db_xref="SubtiList:BG13863" /db_xref="UniProtKB/Swiss-Prot:O34872" /translation="MSLLNDILEFNKTFTEQREYEKYQTSKFPDKKMAILSCMDTRLV ELLPHAMNLRNGDVKIIKSAGALVTHPFGSIMRSILVAVYELNADEVCVIGHHDCGMS KISSKSMLEKIKARGIPEERIETIKYSGVDFDQWFKSFDSVEASVKDSVDVIKHHPLF PENVPVHGLVIDPKTGKLDLIVNGYNN*" /label="ytiB CDS" gene complement(2762645..2763208) /gene="ytiB" /locus_tag="BSU_30690" /old_locus_tag="BSU30690" /label="ytiB gene" misc_feature complement(2763233..2763252) /Source="Nicolas_upshift_promotors" /id="U2379" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=2374 /SigmaFactorBS="gaaataaggcaggcctgagggtttgtctttttttattatgac gaataaacaagggtTGTGATATATTGAAGAGTAAaaagaatagaaagggacaacgaac a" /listShort="ytiB, S1173, luxS, ytkA, S1172, dps" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2763248) /Source="Nicolas_upshifts" /id="U2379" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=2374 /SigmaFactorBS="gaaataaggcaggcctgagggtttgtctttttttattatgac gaataaacaagggtTGTGATATATTGAAGAGTAAaaagaatagaaagggacaacgaac a" /listShort="ytiB, S1173, luxS, ytkA, S1172, dps" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2763302..2763550) /gene="rpmEB" /locus_tag="BSU_30700" /old_locus_tag="BSU30700" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15049826, 16014871, 16547061, 19648245, 20208344" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15049826, 16014871, 16547061, 19648245, 20208344; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L31" /protein_id="NP_390948.1" /db_xref="EnsemblGenomes-Gn:BSU30700" /db_xref="EnsemblGenomes-Tr:CAB15048" /db_xref="GOA:O34967" /db_xref="InterPro:IPR002150" /db_xref="InterPro:IPR027493" /db_xref="InterPro:IPR034704" /db_xref="SubtiList:BG13862" /db_xref="UniProtKB/Swiss-Prot:O34967" /translation="MKEGIHPKNHKVIFQDVNSGYRFLSTSTKTSNETAEWEDGNTYP VIKVEVSSDTHPFYTGRQKFNEKGGRVEQFKKRYNMGK*" /label="rpmEB CDS" gene complement(2763302..2763550) /gene="rpmEB" /locus_tag="BSU_30700" /old_locus_tag="BSU30700" /label="rpmEB gene" downshifts complement(2763323) /Source="Nicolas_upshifts" /id="D1583" /incds=0 /nref=96 /ntot=217 /MaxReadThrough="7.96356" /MaxDrop="4.50701" /score="15.8096104" /energy="-7.5" /TU="U2380" /idTUdmin="U2380" /TUdmin="-2288" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2763578..2763597) /Source="Nicolas_upshift_promotors" /id="U2380" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.571428571428571" /psig="0.994005994005994" /xcortree=663 /SigmaFactorBS="cctattcttaaatgccatgaggtttacgatgtgaaacagagg gaaggatataagaagATTGACAAaacgtttgtaaggTTATAAAATAAAACGTAATTat t" /listShort="rpmEB, ytiB, S1173, luxS, ytkA, S1172" /listLong="dps, S1171, ytkC, S1170, ytkD" /label="promotor_-10" promotor_-35 complement(2763611..2763618) /Source="Nicolas_upshift_promotors" /id="U2380" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.571428571428571" /psig="0.994005994005994" /xcortree=663 /SigmaFactorBS="cctattcttaaatgccatgaggtttacgatgtgaaacagagg gaaggatataagaagATTGACAAaacgtttgtaaggTTATAAAATAAAACGTAATTat t" /listShort="rpmEB, ytiB, S1173, luxS, ytkA, S1172" /listLong="dps, S1171, ytkC, S1170, ytkD" /label="promotor_-35" upshifts complement(2763615) /Source="Nicolas_upshifts" /id="U2380" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.571428571428571" /psig="0.994005994005994" /xcortree=663 /SigmaFactorBS="cctattcttaaatgccatgaggtttacgatgtgaaacagagg gaaggatataagaagATTGACAAaacgtttgtaaggTTATAAAATAAAACGTAATTat t" /listShort="rpmEB, ytiB, S1173, luxS, ytkA, S1172" /listLong="dps, S1171, ytkC, S1170, ytkD" /label="upshifts" promotor_-35 2763677..2763683 /Source="Nicolas_upshift_promotors" /id="U2381" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=902 /SigmaFactorBS="gtaaacctcatggcatttaagaataggaAGAATAAtctaacc gaggaaGCAAATAATAAAcccaaaatacatacagaacgtctttttggaaaggtggttt a" /listShort="ythA, ythB" /listLong="ytzL" /label="promotor_-35" promotor_-10 2763697..2763708 /Source="Nicolas_upshift_promotors" /id="U2381" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=902 /SigmaFactorBS="gtaaacctcatggcatttaagaataggaAGAATAAtctaacc gaggaaGCAAATAATAAAcccaaaatacatacagaacgtctttttggaaaggtggttt a" /listShort="ythA, ythB" /listLong="ytzL" /label="promotor_-10" upshifts 2763709 /Source="Nicolas_upshifts" /id="U2381" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=902 /SigmaFactorBS="gtaaacctcatggcatttaagaataggaAGAATAAtctaacc gaggaaGCAAATAATAAAcccaaaatacatacagaacgtctttttggaaaggtggttt a" /listShort="ythA, ythB" /listLong="ytzL" /label="upshifts" CDS 2763755..2765086 /gene="ythA" /locus_tag="BSU_30710" /old_locus_tag="BSU30710" /EC_number="1.10.3.-" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9852001, 10551842, 15849754, 16850406, 17114254; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative cytochrome bd menaquinol oxidase subunit I" /protein_id="NP_390949.2" /db_xref="EnsemblGenomes-Gn:BSU30710" /db_xref="EnsemblGenomes-Tr:CAB15049" /db_xref="GOA:C0SP90" /db_xref="InterPro:IPR002585" /db_xref="SubtiList:BG13857" /db_xref="UniProtKB/Swiss-Prot:C0SP90" /translation="MDDLVLARSLFGTTMGFHIIFATLGVGLPLMILVAELIYQKTKD DHYAIMAKRWTKAQAVLLGVAIPTGTIAGTQLALLWPGFMEVIGRVMSLPFQIEIYAF FVEALFMSIYVYAADRLSPAMRIVAVFFVLVGAAASAVLITNVHAFEGTPAGFKILNG KITDVDPWAAFFNPSFFITAGHVVLSAFMTGAFIVASVAAYKMIRTRKKERVYRFHRK ALLLALTIGGIFSLLTALNGHESAQMLYEYQPEKLAGAEGLFETRSHAPLAIGGFTDP NEEKVKWAIEIPWALSFLAANRFDTVVKGLNAFPRDEWPPLFIHTLFNAMVGVGMLLI LYSIIGVVWRKVLKKDRFPTWLLIIFMTAGPFSLIGIEFGWIFACTGRQPWVIYHLLK TSDVVTTTGSIGVLFLFFTFVYAVLGAAVVYVLLYYFRKHPVDEDLNTAES*" /label="ythA CDS" gene 2763755..2765086 /gene="ythA" /locus_tag="BSU_30710" /old_locus_tag="BSU30710" /label="ythA gene" CDS 2765130..2766170 /gene="ythB" /locus_tag="BSU_30720" /old_locus_tag="BSU30720" /EC_number="1.10.3.-" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11073895, 15576792, 15849754, 16850406, 10551842; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative cytochrome bd menaquinol oxidase subunit II" /protein_id="NP_390950.1" /db_xref="EnsemblGenomes-Gn:BSU30720" /db_xref="EnsemblGenomes-Tr:CAB15050" /db_xref="GOA:O34505" /db_xref="InterPro:IPR003317" /db_xref="SubtiList:BG13858" /db_xref="UniProtKB/Swiss-Prot:O34505" /translation="MEISTDALIAISIIWGFVFIYAVMATMDFGAGFWSMIYLNKEHM KATDIANRFLSPTWEVTNVFIVAIVVALFSFFPGATFVLGTVLLIPGSMILLLLAIRS GFLVFSNTAKERKTLRYISGISGFIIPAILILVLPVTHGGFIEKTDGIYNLNMSKIFS SPNAYSFIGFAILSTLFLSSLLLADFSNVAEEQDAYRAYRKSALITGPISLLFAVCIM VTMRNEANWLYSGMMNDFSWIIASFITFVIAGIALFLPNKSFGQNIGKPRLALVAIGI QYFLASYAYGRAHLPYMIYPDVTVMSGFTEPATFRALFATYIVAFIILFPGFFFFWKM FMRDKRYIRQEE*" /label="ythB CDS" gene 2765130..2766170 /gene="ythB" /locus_tag="BSU_30720" /old_locus_tag="BSU30720" /label="ythB gene" promotor_-35 2766164..2766170 /Source="Nicolas_upshift_promotors" /id="U2382" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=831 /SigmaFactorBS="atgcgagataaacgctatatccgccaggaGGAATAGagggca agccagccGGCTATACTAATccagaacctttataaggaggggatggcatggagcagaa a" /listShort="ytzL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2766185..2766196 /Source="Nicolas_upshift_promotors" /id="U2382" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=831 /SigmaFactorBS="atgcgagataaacgctatatccgccaggaGGAATAGagggca agccagccGGCTATACTAATccagaacctttataaggaggggatggcatggagcagaa a" /listShort="ytzL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2766195 /Source="Nicolas_upshifts" /id="U2382" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=831 /SigmaFactorBS="atgcgagataaacgctatatccgccaggaGGAATAGagggca agccagccGGCTATACTAATccagaacctttataaggaggggatggcatggagcagaa a" /listShort="ytzL" /GFF_Attribute="listLong" /label="upshifts" CDS 2766224..2766382 /gene="ytzL" /locus_tag="BSU_30739" /old_locus_tag="BSU30739" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 17322312" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097775.1" /db_xref="EnsemblGenomes-Gn:BSU30739" /db_xref="EnsemblGenomes-Tr:CAX52681" /db_xref="InterPro:IPR011437" /db_xref="UniProtKB/Swiss-Prot:C0H3Q2" /translation="MEQKILCEVNNCSYWGKGNKCTADAIYVVSHTGETAENSRETDC KTFKPHDL*" /label="ytzL CDS" gene 2766224..2766382 /gene="ytzL" /locus_tag="BSU_30739" /old_locus_tag="BSU30739" /label="ytzL gene" downshifts 2766371 /Source="Nicolas_upshifts" /id="D1584" /incds=0 /nref=55 /ntot=88 /MaxReadThrough="1.7679" /MaxDrop="7.01398" /score="-5.86934022" /energy="-7" /TU="NA" /idTUdmin="U2382" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2766401..2767288) /gene="mntD" /locus_tag="BSU_30740" /old_locus_tag="BSU30740" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:49350, 15849754, 15948947, 16566604, 16704341, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 49350, 15849754, 15948947, 16566604, 16704341, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="manganese ABC transporter (permease)" /protein_id="NP_390952.1" /db_xref="EnsemblGenomes-Gn:BSU30740" /db_xref="EnsemblGenomes-Tr:CAB15052" /db_xref="GOA:O34500" /db_xref="InterPro:IPR001626" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG13854" /db_xref="UniProtKB/Swiss-Prot:O34500" /translation="MSFEAWIIATGVLVGVSCGLIGTFLVLRSMAMLADAISHTVLLG IVGAFLVTGSLDGIYMFIGAAATGLLTAFLVQLLHSKGVQSDAAIGVVFTSLFAIGVI LLSVYGANVHLDIEHSLMGEIAFVPWNTVTVFGVDIGPKAFWMLASVLVLNVVLISVC YKEFKIASFDPQMALALGIPVLLIHYVQMGMLSLTTVASFDSVGAVLVVAMLIVPPAA AHLLTDRLLYMLILSALIGGLSAVMGYFFATWLNVSISGAMAAMTGVCYASAFLFSPA NGVITKKLRTLNMQKERAG*" /label="mntD CDS" gene complement(2766401..2767288) /gene="mntD" /locus_tag="BSU_30740" /old_locus_tag="BSU30740" /label="mntD gene" downshifts complement(2766424) /Source="Nicolas_upshifts" /id="D1585" /incds=0 /nref=121 /ntot=218 /MaxReadThrough="3.39755" /MaxDrop="6.80546" /score="-8.37820006" /energy="-7" /TU="U2385" /idTUdmin="U2385" /TUdmin="-637" /isTUend="FALSE" /label="downshifts" CDS complement(2767278..2768585) /gene="mntC" /locus_tag="BSU_30750" /old_locus_tag="BSU30750" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:49350, 15849754, 15948947, 16566604, 16704341, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 49350, 15849754, 15948947, 16566604, 16704341, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="manganese ABC transporter (permease)" /protein_id="NP_390953.1" /db_xref="EnsemblGenomes-Gn:BSU30750" /db_xref="EnsemblGenomes-Tr:CAB15053" /db_xref="GOA:O35024" /db_xref="InterPro:IPR001626" /db_xref="InterPro:IPR035568" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13853" /db_xref="UniProtKB/Swiss-Prot:O35024" /translation="MFESLWLQLQHPNTQWVLAGTLLLGTASGVLGSFVLLRKQSLIG DAMAHSALPGVCLAFLFTGQKSLPFFLLGAALAGLLGTFCIQLIPRLSKTKEDSAIGI VLSVFFGVGIILLTYIQQQGAGSQSGLDSFLFGQAASLVRQDIILIAGISAVLLLLCI VFFKEFTLITFDLAFAKGLGIPVRFLNGLLACLIVCAVVIGLQTVGVILMAAMLITPA ITARYWTERLTGMIIIAGITGGVSGVAGTLLSTTMKGMATGPLMILSATLLFLFSMIC APKRGLAAKAIRLMRLRRRTSREQVLLAIYEQYEKNNLCVTVESVRKKRRLSPSLCLK ALNDLEQERCIERIENGIWQITSKGIEKGYHTALKQRMYEVYLMHEMELANIESDQDY FDPDRLPRETRERLYSLLKLYGRMPERRKASHDAEKGQIANEF*" /label="mntC CDS" gene complement(2767278..2768585) /gene="mntC" /locus_tag="BSU_30750" /old_locus_tag="BSU30750" /label="mntC gene" CDS complement(2768591..2769343) /gene="mntB" /locus_tag="BSU_30760" /old_locus_tag="BSU30760" /EC_number="3.6.3.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10760146, 15948947, 16566604, 16704341" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10760146, 15948947, 16566604, 16704341; Product type t: transporter" /codon_start=1 /transl_table=11 /product="manganese ABC transporter (ATP-binding protein)" /protein_id="NP_390954.1" /db_xref="EnsemblGenomes-Gn:BSU30760" /db_xref="EnsemblGenomes-Tr:CAB15054" /db_xref="GOA:O34338" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13852" /db_xref="UniProtKB/Swiss-Prot:O34338" /translation="MFPVELDNVTVAYHKKPVLQDISLQVPEGKLIGIIGPNGAGKST LIKTILGLVPRASGDISIYGKDYKDQRTRIGYVPQRGSVDWDFPTSPLDVVLMGRYGR IGLLKRPKKADVEMAKAALTKVGMHDYAKRQISQLSGGQQQRVFLARALCQNADIYFM DEPFAGVDAATERAIMTLLAELKEKGKTVLVVHHDLQTAEDYFDWILLLHLRKIAFGP TENVFTIENLQKTYGGRLTFLKDKVLAEGHKE*" /label="mntB CDS" gene complement(2768591..2769343) /gene="mntB" /locus_tag="BSU_30760" /old_locus_tag="BSU30760" /label="mntB gene" CDS complement(2769362..2770282) /gene="mntA" /locus_tag="BSU_30770" /old_locus_tag="BSU30770" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10760146, 15948947, 16566604, 16704341" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10760146, 15948947, 16566604, 16704341; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="manganese ABC transporter (manganese binding lipoprotein)" /protein_id="NP_390955.1" /db_xref="EnsemblGenomes-Gn:BSU30770" /db_xref="EnsemblGenomes-Tr:CAB15055" /db_xref="GOA:O34385" /db_xref="InterPro:IPR006127" /db_xref="InterPro:IPR006128" /db_xref="InterPro:IPR006129" /db_xref="SubtiList:BG13851" /db_xref="UniProtKB/Swiss-Prot:O34385" /translation="MRQGLMAAVLFATFALTGCGTDSAGKSADQQLQVTATTSQIADA AENIGGKHVKVTSLMGPGVDPHLYKASQGDTKKLMSADVVLYSGLHLEGKMEDVLQKI GEQKQSAAVAEAIPKNKLIPAGEGKTFDPHVWFSIPLWIYAVDEIEAQFSKAMPQHAD AFRKNAKEYKEDLQYLDKWSRKEIAHIPEKSRVLVTAHDAFAYFGNEYGFKVKGLQGL STDSDYGLRDVQELVDLLTEKQIKAVFVESSVSEKSINAVVEGAKEKGHTVTIGGQLY SDAMGEKGTKEGTYEGMFRHNINTITKALK*" /label="mntA CDS" gene complement(2769362..2770282) /gene="mntA" /locus_tag="BSU_30770" /old_locus_tag="BSU30770" /label="mntA gene" promotor_-10 complement(2770318..2770329) /Source="Nicolas_upshift_promotors" /id="U2383" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.52047952047952" /psig="0.52047952047952" /xcortree=407 /SigmaFactorBS="aataaaacatgcttttggctaatttaatgtCACATGTctaag aactgacaACATAAGATAAAacaatcggacattgatggcaaagaggaggagaaatatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2770319) /Source="Nicolas_upshifts" /id="U2383" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.52047952047952" /psig="0.52047952047952" /xcortree=407 /SigmaFactorBS="aataaaacatgcttttggctaatttaatgtCACATGTctaag aactgacaACATAAGATAAAacaatcggacattgatggcaaagaggaggagaaatatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2770321..2770412) /Source="Nicolas_S_feature" /locus_tag="new_3145997_3146088_c" /HighExp="T-0.40H, Sw, T-1.40H, BC, C90, C30, BI, T0.0H, T-3.40H, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.985, 0.982" /TUlongSig="NA" /TUlongPSig="NA" /label="S1174" promotor_-35 complement(2770343..2770349) /Source="Nicolas_upshift_promotors" /id="U2383" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.52047952047952" /psig="0.52047952047952" /xcortree=407 /SigmaFactorBS="aataaaacatgcttttggctaatttaatgtCACATGTctaag aactgacaACATAAGATAAAacaatcggacattgatggcaaagaggaggagaaatatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2770397 /Source="Nicolas_upshifts" /id="U2384" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.649350649350649" /psig="0.0549450549450549" /xcortree=296 /SigmaFactorBS="tcttagacatgtgacattaaattagccaaaagcatgttttat ttacacaggacaaaaagtttcCCTCATGCAAAATtatcgcgtttggccatttttgtca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2770398..2770417) /Source="Nicolas_upshift_promotors" /id="U2385" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.596403596403596" /psig="0.985014985014985" /xcortree=1526 /SigmaFactorBS="ctgctgacccagccggtttttttatgtaaatcaGCTTGACAa aaatggccaaacgCGATAATTTTGCATGAGGGAaactttttgtcctgtgtaaataaaa c" /listShort="S1174, mntA, mntB, mntC, mntD" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature 2770400..2770412 /Source="Nicolas_upshift_promotors" /id="U2384" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.649350649350649" /psig="0.0549450549450549" /xcortree=296 /SigmaFactorBS="tcttagacatgtgacattaaattagccaaaagcatgttttat ttacacaggacaaaaagtttcCCTCATGCAAAATtatcgcgtttggccatttttgtca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2770412) /Source="Nicolas_upshifts" /id="U2385" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.596403596403596" /psig="0.985014985014985" /xcortree=1526 /SigmaFactorBS="ctgctgacccagccggtttttttatgtaaatcaGCTTGACAa aaatggccaaacgCGATAATTTTGCATGAGGGAaactttttgtcctgtgtaaataaaa c" /listShort="S1174, mntA, mntB, mntC, mntD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2770414..2770495) /Source="Nicolas_S_feature" /locus_tag="new_3146090_3146171_c" /HighExp="T1.30H, T1.0H, C30, T0.30H, T2.0H, T2.30H, T-0.40H, T-1.40H, T-2.40H, GM 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.982" /TUlongSig="NA" /TUlongPSig="NA" /label="S1175" promotor_-35 complement(2770432..2770439) /Source="Nicolas_upshift_promotors" /id="U2385" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.596403596403596" /psig="0.985014985014985" /xcortree=1526 /SigmaFactorBS="ctgctgacccagccggtttttttatgtaaatcaGCTTGACAa aaatggccaaacgCGATAATTTTGCATGAGGGAaactttttgtcctgtgtaaataaaa c" /listShort="S1174, mntA, mntB, mntC, mntD" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2770495) /Source="Nicolas_upshifts" /id="U2386" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.837162837162837" /psig="0.982017982017982" /xcortree=2960 /SigmaFactorBS="agcattttgctATTTTGAAtaaatgacactgtGCTGTTACAG TAAAAGTGTTcgttgaatacatcccttctcgtttggaccggctgctgacccagccggt t" /listShort="S1175, S1174, mntA, mntB, mntC" /listLong="mntD" /label="upshifts" promotor_-10 complement(2770504..2770523) /Source="Nicolas_upshift_promotors" /id="U2386" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.837162837162837" /psig="0.982017982017982" /xcortree=2960 /SigmaFactorBS="agcattttgctATTTTGAAtaaatgacactgtGCTGTTACAG TAAAAGTGTTcgttgaatacatcccttctcgtttggaccggctgctgacccagccggt t" /listShort="S1175, S1174, mntA, mntB, mntC" /listLong="mntD" /label="promotor_-10" promotor_-35 complement(2770537..2770544) /Source="Nicolas_upshift_promotors" /id="U2386" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.837162837162837" /psig="0.982017982017982" /xcortree=2960 /SigmaFactorBS="agcattttgctATTTTGAAtaaatgacactgtGCTGTTACAG TAAAAGTGTTcgttgaatacatcccttctcgtttggaccggctgctgacccagccggt t" /listShort="S1175, S1174, mntA, mntB, mntC" /listLong="mntD" /label="promotor_-35" CDS complement(2770562..2771677) /gene="menC" /locus_tag="BSU_30780" /old_locus_tag="BSU30780" /EC_number="4.2.1.113" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:6780514, 8566759, 9139683, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6780514, 8566759, 9139683, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="O-succinylbenzoate-CoA synthase" /protein_id="NP_390956.1" /db_xref="EnsemblGenomes-Gn:BSU30780" /db_xref="EnsemblGenomes-Tr:CAB15056" /db_xref="GOA:O34514" /db_xref="InterPro:IPR010197" /db_xref="InterPro:IPR013341" /db_xref="InterPro:IPR013342" /db_xref="InterPro:IPR029017" /db_xref="InterPro:IPR029065" /db_xref="InterPro:IPR034390" /db_xref="InterPro:IPR036849" /db_xref="SubtiList:BG13847" /db_xref="UniProtKB/Swiss-Prot:O34514" /translation="MIEIEKITLYHLSMNLKKPFKNSIETLQERKFLIVEAIDTSGVT GWGEVSAFSSPWYTEETIGTCLHMLKDFFIPNVVGREFNHPSEVPDSLARYKGNRMAK AGLESAVWDIYAKKKGVSLAEALGGTRDKVPAGVVVGLAPLDDMLKEIESYQKEGYQR IKIKIQPGQDVELVKAIRSRFPTIPLMADANSSYELKDISRLKELDDYHLMMIEQPLQ ADDIVDHRHLQKHLKTAICLDESICSVDDARRAIELGSCKIINIKPSRVGGLTEALKI HDLCKEHHMQVWCGGMLETGISRAQNVALASLPQFTIPGDISSSSRYWDEDIVTPDIR IDNGFISVSKQPGLGVEVNQDIMRKYVTKMDVFTQHG*" /label="menC CDS" gene complement(2770562..2771677) /gene="menC" /locus_tag="BSU_30780" /old_locus_tag="BSU30780" /label="menC gene" downshifts complement(2770605) /Source="Nicolas_upshifts" /id="D1586" /incds=0 /nref=12 /ntot=179 /MaxReadThrough="3.8638" /MaxDrop="2.96378" /score="29.7201414" /energy="-11.1" /TU="U2387,U2388" /idTUdmin="U2388" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(2771674..2773134) /gene="menE" /locus_tag="BSU_30790" /old_locus_tag="BSU30790" /EC_number="6.2.1.26" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6780514, 6780515, 8566759, 9139683, 12682299, 28559280" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6780514, 6780515, 8566759, 9139683, 12682299, 28559280; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="O-succinylbenzoic acid-CoA ligase" /protein_id="NP_390957.1" /db_xref="EnsemblGenomes-Gn:BSU30790" /db_xref="EnsemblGenomes-Tr:CAB15057" /db_xref="GOA:P23971" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR010192" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="PDB:5BUQ" /db_xref="PDB:5BUR" /db_xref="PDB:5BUS" /db_xref="PDB:5GTD" /db_xref="PDB:5X8F" /db_xref="PDB:5X8G" /db_xref="SubtiList:BG10687" /db_xref="UniProtKB/Swiss-Prot:P23971" /translation="MLTEQPNWLMQRAQLTPERIALIYEDQTVTFAELFAASKRMAEQ LAAHSVRKGDTAAILLQNRAEMVYAVHACFLLGVKAVLLNTKLSTHERLFQLEDSGSG FLLTDSSFEKKEYEHIVQTIDVDELMKEAAEEIEIEAYMQMDATATLMYTSGTTGKPK GVQQTFGNHYFSAVSSALNLGITEQDRWLIALPLFHISGLSALFKSVIYGMTVVLHQR FSVSDVLHSINRHEVTMISAVQTMLASLLEETNRCPESIRCILLGGGPAPLPLLEECR EKGFPVFQSYGMTETCSQIVTLSPEFSMEKLGSAGKPLFSCEIKIERDGQVCEPYEHG EIMVKGPNVMKSYFNRESANEASFQNGWLKTGDLGYLDNEGFLYVLDRRSDLIISGGE NIYPAEVESVLLSHPAVAEAGVSGAEDKKWGKVPHAYLVLHKPVSAGELTDYCKERLA KYKIPAKFFVLDRLPRNASNKLLRNQLKDARKGELL*" /label="menE CDS" gene complement(2771674..2773134) /gene="menE" /locus_tag="BSU_30790" /old_locus_tag="BSU30790" /label="menE gene" promotor_-10 complement(2772577..2772595) /Source="Nicolas_upshift_promotors" /id="U2387" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=257 /SigmaFactorBS="cgttcggaaaccattatttcagtgcGGTGTCGtccgctctta atttGGGTATAACAGAACAAGACcgctggcttatcgcattgccgctctttcatatcag c" /listShort="menC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2772581) /Source="Nicolas_upshifts" /id="U2387" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=257 /SigmaFactorBS="cgttcggaaaccattatttcagtgcGGTGTCGtccgctctta atttGGGTATAACAGAACAAGACcgctggcttatcgcattgccgctctttcatatcag c" /listShort="menC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2772610..2772616) /Source="Nicolas_upshift_promotors" /id="U2387" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=257 /SigmaFactorBS="cgttcggaaaccattatttcagtgcGGTGTCGtccgctctta atttGGGTATAACAGAACAAGACcgctggcttatcgcattgccgctctttcatatcag c" /listShort="menC" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2773223) /Source="Nicolas_upshifts" /id="D1587" /incds=0 /nref=1 /ntot=97 /MaxReadThrough="4.92536" /MaxDrop="2.4145" /score="1.01127104" /energy="-10.8" /TU="U2388" /idTUdmin="U2389" /TUdmin=682 /isTUend="FALSE" /label="downshifts" CDS complement(2773225..2774040) /gene="menB" /locus_tag="BSU_30800" /old_locus_tag="BSU30800" /EC_number="4.1.3.36" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:6780514, 6780515, 8566759, 9139683, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6780514, 6780515, 8566759, 9139683, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydroxynapthoic acid synthetase" /protein_id="NP_390958.1" /db_xref="EnsemblGenomes-Gn:BSU30800" /db_xref="EnsemblGenomes-Tr:CAB15058" /db_xref="GOA:P23966" /db_xref="InterPro:IPR001753" /db_xref="InterPro:IPR010198" /db_xref="InterPro:IPR014748" /db_xref="InterPro:IPR018376" /db_xref="InterPro:IPR029045" /db_xref="SubtiList:BG10686" /db_xref="UniProtKB/Swiss-Prot:P23966" /translation="MAEWKTKRTYDEILYETYNGIAKITINRPEVHNAFTPKTVAEMI DAFADARDDQNVGVIVLAGAGDKAFCSGGDQKVRGHGGYVGDDQIPRLNVLDLQRLIR VIPKPVVAMVSGYAIGGGHVLHIVCDLTIAADNAIFGQTGPKVGSFDAGYGSGYLARI VGHKKAREIWYLCRQYNAQEALDMGLVNTVVPLEQLEEETIKWCEEMLEKSPTALRFL KAAFNADTDGLAGIQQFAGDATLLYYTTDEAKEGRDSFKEKRKPDFGQFPRFP*" /label="menB CDS" gene complement(2773225..2774040) /gene="menB" /locus_tag="BSU_30800" /old_locus_tag="BSU30800" /label="menB gene" CDS complement(2774075..2774899) /gene="menH" /locus_tag="BSU_30810" /old_locus_tag="BSU30810" /EC_number="4.2.99.20" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12454479, 23637813; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase" /protein_id="NP_390959.1" /db_xref="EnsemblGenomes-Gn:BSU30810" /db_xref="EnsemblGenomes-Tr:CAB15059" /db_xref="GOA:P23974" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR000639" /db_xref="InterPro:IPR022485" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG10685" /db_xref="UniProtKB/Swiss-Prot:P23974" /translation="MGTVNITVSDGVRYAVADEGPNASEAVVCLHGFTGSKQSWTFLD EMLPDSRLIKIDCLGHGETDAPLNGKRYSTTRQVSDLAEIFDQLKLHKVKLIGYSMGG RLAYSFAMTYPERVSALVLESTTPGLKTLGERRERIMRDRKLADFILRDGLEAFVAYW ENIPLFSSQQRLAEDIRYRIRSGRLRNNKIGLANSLTGMGTGSQPSLWSRVEEIDVPV LLICGEWDEKFCAINQEVHKMLPSSRIEIVPKAGHTVHVEQPRLFGKIVSEFLTSI*" /label="menH CDS" gene complement(2774075..2774899) /gene="menH" /locus_tag="BSU_30810" /old_locus_tag="BSU30810" /label="menH gene" promotor_-10 complement(2774157..2774176) /Source="Nicolas_upshift_promotors" /id="U2388" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.534465534465534" /psig="0.993006993006993" /xcortree=2696 /SigmaFactorBS="aattttgcgccatcaatcaagaGGTGcataagatgcttcctT CTAGTAGAATAGAGATTGTtccaaaagcaggacatacggtccatgtggagcagccgcg a" /listShort="menB, menE, menC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2774157) /Source="Nicolas_upshifts" /id="U2388" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.534465534465534" /psig="0.993006993006993" /xcortree=2696 /SigmaFactorBS="aattttgcgccatcaatcaagaGGTGcataagatgcttcctT CTAGTAGAATAGAGATTGTtccaaaagcaggacatacggtccatgtggagcagccgcg a" /listShort="menB, menE, menC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2774192..2774195) /Source="Nicolas_upshift_promotors" /id="U2388" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.534465534465534" /psig="0.993006993006993" /xcortree=2696 /SigmaFactorBS="aattttgcgccatcaatcaagaGGTGcataagatgcttcctT CTAGTAGAATAGAGATTGTtccaaaagcaggacatacggtccatgtggagcagccgcg a" /listShort="menB, menE, menC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2774323) /Source="Nicolas_upshifts" /id="U2389" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.706293706293706" /psig="0.706293706293706" /xcortree=1445 /SigmaFactorBS="gctgaagatattcggtacAGGATACgatcgggccgtctgCGG AACAATAAGattgggcttgcgaacagtttaaccggcatgggcaccggttcacagcctt c" /listShort="menB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2774333..2774344) /Source="Nicolas_upshift_promotors" /id="U2389" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.706293706293706" /psig="0.706293706293706" /xcortree=1445 /SigmaFactorBS="gctgaagatattcggtacAGGATACgatcgggccgtctgCGG AACAATAAGattgggcttgcgaacagtttaaccggcatgggcaccggttcacagcctt c" /listShort="menB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2774359..2774365) /Source="Nicolas_upshift_promotors" /id="U2389" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.706293706293706" /psig="0.706293706293706" /xcortree=1445 /SigmaFactorBS="gctgaagatattcggtacAGGATACgatcgggccgtctgCGG AACAATAAGattgggcttgcgaacagtttaaccggcatgggcaccggttcacagcctt c" /listShort="menB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2774887..2776629) /gene="menD" /locus_tag="BSU_30820" /old_locus_tag="BSU30820" /EC_number="2.2.1.9" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:6780514, 8169214, 8566759, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6780514, 8169214, 8566759, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-oxoglutarate decarboxylase and 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylic-acid synthase" /protein_id="NP_390960.1" /db_xref="EnsemblGenomes-Gn:BSU30820" /db_xref="EnsemblGenomes-Tr:CAB15060" /db_xref="GOA:P23970" /db_xref="InterPro:IPR004433" /db_xref="InterPro:IPR011766" /db_xref="InterPro:IPR012001" /db_xref="InterPro:IPR029035" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR032264" /db_xref="PDB:2X7J" /db_xref="SubtiList:BG10683" /db_xref="UniProtKB/Swiss-Prot:P23970" /translation="MTVNPITHYIGSFIDEFALSGITDAVVCPGSRSTPLAVLCAAHP DISVHVQIDERSAGFFALGLAKAKQRPVLLICTSGTAAANFYPAVVEAHYSRVPIIVL TADRPHELREVGAPQAINQHFLFGNFVKFFTDSALPEESPQMLRYIRTLASRAAGEAQ KRPMGPVHVNVPLREPLMPDLSDEPFGRMRTGRHVSVKTGTQSVDRESLSDVAEMLAE AEKGMIVCGELHSDADKENIIALSKALQYPILADPLSNLRNGVHDKSTVIDAYDSFLK DDELKRKLRPDVVIRFGPMPVSKPVFLWLKDDPTIQQIVIDEDGGWRDPTQASAHMIH CNASVFAEEIMAGLTAATRSSEWLEKWQFVNGRFREHLQTISSEDVSFEGNLYRILQH LVPENSSLFVGNSMPIRDVDTFFEKQDRPFRIYSNRGANGIDGVVSSAMGVCEGTKAP VTLVIGDLSFYHDLNGLLAAKKLGIPLTVILVNNDGGGIFSFLPQASEKTHFEDLFGT PTGLDFKHAAALYGGTYSCPASWDEFKTAYAPQADKPGLHLIEIKTDRQSRVQLHRDM LNEAVREVKKQWEL*" /label="menD CDS" gene complement(2774887..2776629) /gene="menD" /locus_tag="BSU_30820" /old_locus_tag="BSU30820" /label="menD gene" CDS complement(2776626..2778041) /gene="menF" /locus_tag="BSU_30830" /old_locus_tag="BSU30830" /EC_number="5.4.4.2" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6780514, 8169214, 8566759" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6780514, 8169214, 8566759; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="menaquinone-specific isochorismate synthase" /protein_id="NP_390961.1" /db_xref="EnsemblGenomes-Gn:BSU30830" /db_xref="EnsemblGenomes-Tr:CAB15061" /db_xref="GOA:P23973" /db_xref="InterPro:IPR004561" /db_xref="InterPro:IPR005801" /db_xref="InterPro:IPR015890" /db_xref="InterPro:IPR034681" /db_xref="SubtiList:BG10682" /db_xref="UniProtKB/Swiss-Prot:P23973" /translation="MVTTVQRTFRKEVLHALHKAKEVNHAVLISYSRQIESLDPLSFF NYGAKKYTGNRFFWSDPESELTIVGLGKEAVFQTNQKNSERYREVFEQWERFKKTAFH IYEEEKLQHSAVGPVLFGGFSFDPCEERGSQWDHFSEGDFFVPALMLTMTAEGPFLTV NRWVSGGEDAEAVLEGLKAFAAEFMVPDFKQEDQAVIAAAEELDKDDWLKAIETATSQ IKEKQYDKVVLARELLLTFDGPIQIEPVLKTLLDDQQTSYVFAIEQEGKTFVGASPER LIKRDGGTVMSSCLAGSIKRGVNEEDDRRIGLELLNDEKNLLEHDIVVGMIHNAFVSS CSEVEKPDGPVLYKTKSVQHLFTPIVGQLRESASIFDLIEKLHPTPALGGSPQEKAVD VIREIEPMSRGWYAAPIGWIDSQDNGEFAVAIRSGLIEGSTARLFAGCGIVEDSEPIS EYEETQIKLKPMISALGGERR*" /label="menF CDS" gene complement(2776626..2778041) /gene="menF" /locus_tag="BSU_30830" /old_locus_tag="BSU30830" /label="menF gene" S_feature complement(2778042..2778154) /Source="Nicolas_S_feature" /locus_tag="new_3153718_3153830_c" /HighExp="dia5, LBGstat, Diami, LBGtran, dia15, H2O2, G180, G150, LPhT, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1176" promotor_-10 complement(2778134..2778153) /Source="Nicolas_upshift_promotors" /id="U2390" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.721278721278721" /psig=1 /xcortree=1834 /SigmaFactorBS="caacctttgctatcagtggagaaagaaatttaagctttgttt CTTTttcatttctgaaattAGGTTTATAATAGGTAAGGCaggccatttggactgcatg a" /listShort="S1176, menF, menD, ytxM" /listLong="menB, menE, menC" /label="promotor_-10" upshifts complement(2778154) /Source="Nicolas_upshifts" /id="U2390" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.721278721278721" /psig=1 /xcortree=1834 /SigmaFactorBS="caacctttgctatcagtggagaaagaaatttaagctttgttt CTTTttcatttctgaaattAGGTTTATAATAGGTAAGGCaggccatttggactgcatg a" /listShort="S1176, menF, menD, ytxM" /listLong="menB, menE, menC" /label="upshifts" S_feature complement(2778156..2778306) /Source="Nicolas_S_feature" /locus_tag="new_3153832_3153982_c" /HighExp="S8, S7, S6, S5, BT, S4, Pyr, B36, G/S, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1177" promotor_-35 complement(2778169..2778172) /Source="Nicolas_upshift_promotors" /id="U2390" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.721278721278721" /psig=1 /xcortree=1834 /SigmaFactorBS="caacctttgctatcagtggagaaagaaatttaagctttgttt CTTTttcatttctgaaattAGGTTTATAATAGGTAAGGCaggccatttggactgcatg a" /listShort="S1176, menF, menD, ytxM" /listLong="menB, menE, menC" /label="promotor_-35" promotor_-35 2778267..2778273 /Source="Nicolas_upshift_promotors" /id="U2391" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=863 /SigmaFactorBS="aaaacctcctatattcctccacccgccatttaTGAAAGTtct caggcgatctGTTCATACTAAAggtatgcatcacagagaaacgaggcgatcacattgc t" /listShort="yteA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2778287..2778306) /Source="Nicolas_upshift_promotors" /id="U2392" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1266 /SigmaFactorBS="attttttaaatgctgaagctgttctttcgtaagcaatGTGAT CGCCTcgtttctctgtgaTGCATACCTTTAGTATGAACagatcgcctgagaactttca t" /listShort="S1177, S1176, menF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2778287..2778298 /Source="Nicolas_upshift_promotors" /id="U2391" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=863 /SigmaFactorBS="aaaacctcctatattcctccacccgccatttaTGAAAGTtct caggcgatctGTTCATACTAAAggtatgcatcacagagaaacgaggcgatcacattgc t" /listShort="yteA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2778295 /Source="Nicolas_upshifts" /id="U2391" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=863 /SigmaFactorBS="aaaacctcctatattcctccacccgccatttaTGAAAGTtct caggcgatctGTTCATACTAAAggtatgcatcacagagaaacgaggcgatcacattgc t" /listShort="yteA" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2778306) /Source="Nicolas_upshifts" /id="U2392" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1266 /SigmaFactorBS="attttttaaatgctgaagctgttctttcgtaagcaatGTGAT CGCCTcgtttctctgtgaTGCATACCTTTAGTATGAACagatcgcctgagaactttca t" /listShort="S1177, S1176, menF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2778320..2778329) /Source="Nicolas_upshift_promotors" /id="U2392" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1266 /SigmaFactorBS="attttttaaatgctgaagctgttctttcgtaagcaatGTGAT CGCCTcgtttctctgtgaTGCATACCTTTAGTATGAACagatcgcctgagaactttca t" /listShort="S1177, S1176, menF" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2778331..2779050 /gene="yteA" /locus_tag="BSU_30840" /old_locus_tag="BSU30840" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15496987; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative regulatory protein" /protein_id="NP_390962.2" /db_xref="EnsemblGenomes-Gn:BSU30840" /db_xref="EnsemblGenomes-Tr:CAB15062" /db_xref="GOA:P42408" /db_xref="InterPro:IPR000962" /db_xref="InterPro:IPR014240" /db_xref="InterPro:IPR037187" /db_xref="SubtiList:BG11200" /db_xref="UniProtKB/Swiss-Prot:P42408" /translation="MLTKEQLQHLKNELEQTKKDILNRFKDNDHFQLNSAFPYDSWGE LSAYDNHPGDQATELYEREKDIALDLHEREHLRDIEHSLKAIENGTYGICEVSGKEIP FERLEALPTATTLAEYSSQDVVSKDRPIEEETPFGQFEFDDDEEIRAPYDSEDSYQDV EKYGNSQTPQDMENPPLSYDDMTMNAEENIGNTESYENFIATDITGKEITVYQSRAHE RYEEELDEEGIMTTFGDLHAD*" /label="yteA CDS" gene 2778331..2779050 /gene="yteA" /locus_tag="BSU_30840" /old_locus_tag="BSU30840" /label="yteA gene" S_feature complement(2778401..2779058) /Source="Nicolas_S_feature" /locus_tag="new_3154077_3154734_c" /HighExp="S8, S6, S7, BT, B36, S5, S4, G/S, Pyr, S3" /AntisenseName="yteA" /AntisenseCor="0.85796245341056299" /AntisenseRegPval="-78.5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1178" downshifts 2779039 /Source="Nicolas_upshifts" /id="D1588" /incds=0 /nref=23 /ntot=40 /MaxReadThrough="0.72949" /MaxDrop="5.85132" /score="2.75726503" /energy="-10.1" /TU="NA" /idTUdmin="U2391" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" CDS complement(2779059..2779877) /gene="ytdA" /locus_tag="BSU_30850" /old_locus_tag="BSU30850" /EC_number="2.7.7.9" /function="16.8: Protect" /function="16.14: Store" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative UTP-glucose-1-phosphate uridylyltransferase" /protein_id="NP_390963.1" /db_xref="EnsemblGenomes-Gn:BSU30850" /db_xref="EnsemblGenomes-Tr:CAB15063" /db_xref="GOA:P42407" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG11199" /db_xref="UniProtKB/Swiss-Prot:P42407" /translation="MIKKAIIPAGGFGTRNLPVTKVIPKEMFPVGSKPVIHYLVEELK ESGIEDILMVVSSHKNLIVDYFDSSLALEAFLASKNKLHLLREHPIPDIRIHYVRQPY AKGLGDAISFGKQFAGGEPFAVVLPDDLIFSANQPALGQLIEAYTKYQSSVIGLKETK TEDLHHYGVIKGEPVEKGLYRIQDIVEKPKQNPPSHFAAAGRYIFTPDIFNELEALEA DSGGEVQVTDAIKASLGACTVYGKLLEGERYDIGLQKDYLKLIYDMLKTEKNPQ*" /label="ytdA CDS" gene complement(2779059..2779877) /gene="ytdA" /locus_tag="BSU_30850" /old_locus_tag="BSU30850" /label="ytdA gene" promotor_-10 complement(2779898..2779917) /Source="Nicolas_upshift_promotors" /id="U2393" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1317 /SigmaFactorBS="tctgcccagttgcttccgcctaatttcagatgTACAAACATc gggatgcgctcttGGAATATCATGTAATAAACAtgagctgaggggaaaataccatgat a" /listShort="ytdA, S1178" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2779912) /Source="Nicolas_upshifts" /id="U2393" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1317 /SigmaFactorBS="tctgcccagttgcttccgcctaatttcagatgTACAAACATc gggatgcgctcttGGAATATCATGTAATAAACAtgagctgaggggaaaataccatgat a" /listShort="ytdA, S1178" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2779932..2779940) /Source="Nicolas_upshift_promotors" /id="U2393" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1317 /SigmaFactorBS="tctgcccagttgcttccgcctaatttcagatgTACAAACATc gggatgcgctcttGGAATATCATGTAATAAACAtgagctgaggggaaaataccatgat a" /listShort="ytdA, S1178" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2779978..2779986 /Source="Nicolas_upshift_promotors" /id="U2394" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1301 /SigmaFactorBS="acatctgaaattaggcggaagcaactgggcagaaagcgGAAT CACGAaccagcccttttTTAATAGGATATTGATATATgaccagtaatcttgtaaagga g" /listShort="ytcA, ytcB, ytcC, S1179" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2779999..2780018 /Source="Nicolas_upshift_promotors" /id="U2394" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1301 /SigmaFactorBS="acatctgaaattaggcggaagcaactgggcagaaagcgGAAT CACGAaccagcccttttTTAATAGGATATTGATATATgaccagtaatcttgtaaagga g" /listShort="ytcA, ytcB, ytcC, S1179" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2780000 /Source="Nicolas_upshifts" /id="U2394" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1301 /SigmaFactorBS="acatctgaaattaggcggaagcaactgggcagaaagcgGAAT CACGAaccagcccttttTTAATAGGATATTGATATATgaccagtaatcttgtaaagga g" /listShort="ytcA, ytcB, ytcC, S1179" /GFF_Attribute="listLong" /label="upshifts" CDS 2780049..2781335 /gene="ytcA" /locus_tag="BSU_30860" /old_locus_tag="BSU30860" /EC_number="1.1.1.22" /function="16.14: Store" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative UDP-glucose dehydrogenase" /protein_id="NP_390964.1" /db_xref="EnsemblGenomes-Gn:BSU30860" /db_xref="EnsemblGenomes-Tr:CAB15064" /db_xref="GOA:O34862" /db_xref="InterPro:IPR001732" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR014026" /db_xref="InterPro:IPR014027" /db_xref="InterPro:IPR017476" /db_xref="InterPro:IPR028357" /db_xref="InterPro:IPR036220" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13828" /db_xref="UniProtKB/Swiss-Prot:O34862" /translation="MKICVVGAGYVGLTLSAALASIGHDMICTDKDVKKIGQLKKGVI PFYEPGLSDAILRCGNLSFSSEVKSSMEECPVIFIAVGTPPRSDGSADTKALQSVIGD LSEAIRSYKTIITKSTVPPGTNENIAKQLIASGVSKNLFNIVSNPEFLREGNALYDML HPDKTVIGVQEEDHVSAAIVKSIYKHIDTPFIVTSLAGAELIKYANNFFLAAKISFIN EMARICEAYQSDISDISRAIGLDPRIGKHFLQAGIGYGGSCFPKDLQALQFAAQEKNT ETFLLRAVQHINDTQLGLYIKKIQSFFETLQGKKAAVLGISFKPNTDDIRNSQAVRLM ERLAELGCDVHAYDPEAVLPEHLRQHVTQHSQAFDAIEESDFLFLATEWSEFLAFDWK KAADIMKGRLVIDGRNVLKKELIEACGLICTGVGRP*" /label="ytcA CDS" gene 2780049..2781335 /gene="ytcA" /locus_tag="BSU_30860" /old_locus_tag="BSU30860" /label="ytcA gene" CDS 2781332..2782282 /gene="ytcB" /locus_tag="BSU_30870" /old_locus_tag="BSU30870" /EC_number="5.1.3.2" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative UDP-glucose epimerase" /protein_id="NP_390965.1" /db_xref="EnsemblGenomes-Gn:BSU30870" /db_xref="EnsemblGenomes-Tr:CAB15065" /db_xref="GOA:O34886" /db_xref="InterPro:IPR001509" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13829" /db_xref="UniProtKB/Swiss-Prot:O34886" /translation="MKILVTGAAGFIGSHLCEELLKDKKHNVIGIDDFIGPTPFSLKL KNLKNLLPEKRFTFIKENLLTADLASLLEGVDVIFHLAAIPGVRSSWGNHFHPYAAHN IQALQRLLEACREHSIQTFVFASTSSVYGEKQGKVSENTSLSPLSPYGVTKLTGEKLC HVYKQSFGIPIVILRFFTVYGPRQRPDMAFHRLIKQHLQQKPLTIFGDGQQSRDFTYI SDCVKGITAVLGKPHLIGETVNIGGAERASVLKVVSLIEDISGRKATLHFSDKIAGEP SNTWADISKAKQLLHYDPATSLKDGLTNEIAYLSSLYQGE*" /label="ytcB CDS" gene 2781332..2782282 /gene="ytcB" /locus_tag="BSU_30870" /old_locus_tag="BSU30870" /label="ytcB gene" CDS 2782285..2783508 /gene="ytcC" /locus_tag="BSU_30880" /old_locus_tag="BSU30880" /EC_number="2.4.1.-" /function="16.14: Store" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glucosyltransferase" /protein_id="NP_390966.1" /db_xref="EnsemblGenomes-Gn:BSU30880" /db_xref="EnsemblGenomes-Tr:CAB15066" /db_xref="GOA:O34413" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR028098" /db_xref="SubtiList:BG13830" /db_xref="UniProtKB/Swiss-Prot:O34413" /translation="MKLAFICTEKLPAPAVRGGAIQMMIDGVTPYFSSRYDLTIFSIE DPSLPKRETKDGVHYIHLPKEHYREAVAEELRASSFDLIHVFNRPLNVSLYKKASPNS KIVLSLHNEMFSEKKMTFAQGKEVLDNVSMITTVSEFIKQTVIERFPEAEDITKVVYS GVDLNSYPPVWTMKGSAVRKTYRKKYGIEDKKVILFAGRLSPTKGPHLLIHSMRRILQ QHPDAVLVIAGGKWFSDDSENQYVTYLRTLALPYRDHIIFTKFIPADDIPNLFLMADV FVCSSQWNEPLARVNYEAMAAGTPLITTNRGGNGEVVKHEVTGLVIDSYNKPSSFAKA IDRAFTDQELMNKMTKNARKHVEALFTFTHAAKRLNTVYQSVLTPKNKQFPPPFLTQN FDLSSINQLFVKAKT*" /label="ytcC CDS" gene 2782285..2783508 /gene="ytcC" /locus_tag="BSU_30880" /old_locus_tag="BSU30880" /label="ytcC gene" downshifts complement(2783432) /Source="Nicolas_upshifts" /id="D1589" /incds=1 /nref=1 /ntot=10 /MaxReadThrough="1.32025" /MaxDrop="3.47267" /score="-3.65321449" /energy="-3.1" /TU="NA" /idTUdmin="U2395" /TUdmin=66 /isTUend="FALSE" /label="downshifts" S_feature 2783509..2784076 /Source="Nicolas_S_feature" /locus_tag="new_3159185_3159752" /HighExp="S8, S7, BT, S6, C30, Pyr, S5, G/S, C90, Glucon" /AntisenseName="ytxO" /AntisenseCor="0.86121563743373297" /AntisenseRegPval="-79.7" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S1179" CDS complement(2783582..2784013) /gene="cotOO" /locus_tag="BSU_30890" /old_locus_tag="BSU30890" /experiment="publication(s) with functional evidences, PMID:19933362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19933362; Product type s: structure" /codon_start=1 /transl_table=11 /product="outer spore coat protein" /protein_id="NP_390967.1" /db_xref="EnsemblGenomes-Gn:BSU30890" /db_xref="EnsemblGenomes-Tr:CAB15067" /db_xref="SubtiList:BG11382" /db_xref="UniProtKB/Swiss-Prot:P46916" /translation="MRSSRQKASISKLDLDQFVFTPPGPMGWQAHDSISAEKEEEEKH LDVGSIRELPHINAPKEYQKETKEKETDRKIVDDEEETKFETTLEPEEERDSKRSAPP YEEEDEDEEPDLAEEAKVEIIILPSESKPAPWFSQTVKRKA*" /label="cotOO CDS" gene complement(2783582..2784013) /gene="cotOO" /locus_tag="BSU_30890" /old_locus_tag="BSU30890" /label="cotOO gene" downshifts complement(2783608) /Source="Nicolas_upshifts" /id="D1590" /incds=0 /nref=11 /ntot=36 /MaxReadThrough="3.07378" /MaxDrop="4.8822" /score="9.30990044" /energy="-8.3" /TU="U2395" /idTUdmin="U2395" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" CDS complement(2784015..2785070) /gene="cotS" /locus_tag="BSU_30900" /old_locus_tag="BSU30900" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:7545510, 9603889, 10234840, 11737650, 14702409" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7545510, 9603889, 10234840, 11737650, 14702409; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein" /protein_id="NP_390968.1" /db_xref="EnsemblGenomes-Gn:BSU30900" /db_xref="EnsemblGenomes-Tr:CAB15068" /db_xref="GOA:P46914" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR014255" /db_xref="SubtiList:BG11380" /db_xref="UniProtKB/Swiss-Prot:P46914" /translation="MYQKEHEEQIVSEILSYYPFHIDHVALKSNKSGRKIWEVETDHG PKLLKEAQMKPERMLFITQAHAHLQEKGLPIAPIHQTKNGGSCLGTDQVSYSLYDKVT GKEMIYYDAEQMKKVMSFAGHFHHASKGYVCTDESKKRSRLGKWHKLYRWKLQELEGN MQIAASYPDDVFSQTFLKHADKMLARGKEALRALDDSEYETWTKETLEHGGFCFQDFT LARLTEIEGEPFLKELHSITYDLPSRDLRILLNKVMVKLSVWDTDFMVALLAAYDAVY PLTEKQYEVLWIDLAFPHLFCAIGHKYYLKQKKTWSDEKYNWALQNMISVEESKDSFL DKLPELYKKIKAYREAN*" /label="cotS CDS" gene complement(2784015..2785070) /gene="cotS" /locus_tag="BSU_30900" /old_locus_tag="BSU30900" /label="cotS gene" CDS complement(2785085..2786218) /gene="cotSA" /locus_tag="BSU_30910" /old_locus_tag="BSU30910" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9603889, 10234840, 11737650" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9603889, 10234840, 11737650; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein" /protein_id="NP_390969.1" /db_xref="EnsemblGenomes-Gn:BSU30910" /db_xref="EnsemblGenomes-Tr:CAB15069" /db_xref="GOA:P46915" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR028098" /db_xref="SubtiList:BG11381" /db_xref="UniProtKB/Swiss-Prot:P46915" /translation="MKIALIATEKLPVPSVRGGAIQIYLEAVAPLIAKKHEVTVFSIK DPNLADREKVDGVHYVHLDEDRYEEAVGAELKKSRFDLVHVCNRPSWVPKLKKQAPDA VFILSVHNEMFAYDKISQAEGEICIDSVAQIVTVSDYIGQTITSRFPSARSKTKTVYS GVDLKTYHPRWTNEGQRAREEMRSELGLHGKKIVLFVGRLSKVKGPHILLQALPDIIE EHPDVMMVFIGSKWFGDNELNNYVKHLHTLGAMQKDHVTFIQFVKPKDIPRLYTMSDV FVCSSQWQEPLARVHYEAMAAGLPIITSNRGGNPEVIEEGKNGYIIHDFENPKQYAER INDLLSSSEKRERLGKYSRREAESNFGWQRVAENLLSVYEKNR*" /label="cotSA CDS" gene complement(2785085..2786218) /gene="cotSA" /locus_tag="BSU_30910" /old_locus_tag="BSU30910" /label="cotSA gene" promotor_-10 complement(2786251..2786270) /Source="Nicolas_upshift_promotors" /id="U2395" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1345 /SigmaFactorBS="tctggttgtttacccgttttgtttttagggcagtcccaTTCC GCACAAgttggttgttcaGCCGTATCATGATTCTAACTagttaaaaatcatgcaggaa t" /listShort="cotSA, cotS, ytxO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2786270) /Source="Nicolas_upshifts" /id="U2395" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1345 /SigmaFactorBS="tctggttgtttacccgttttgtttttagggcagtcccaTTCC GCACAAgttggttgttcaGCCGTATCATGATTCTAACTagttaaaaatcatgcaggaa t" /listShort="cotSA, cotS, ytxO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2786283..2786292) /Source="Nicolas_upshift_promotors" /id="U2395" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1345 /SigmaFactorBS="tctggttgtttacccgttttgtttttagggcagtcccaTTCC GCACAAgttggttgttcaGCCGTATCATGATTCTAACTagttaaaaatcatgcaggaa t" /listShort="cotSA, cotS, ytxO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2786356..2786365 /Source="Nicolas_upshift_promotors" /id="U2396" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1346 /SigmaFactorBS="aacaaccagattcatctattaaatatagtcaaataACTCAAT CATtttttccttttgaTTCATAAGGTAGGAGTAAAAcaggtaaggatgtgtcctttaa t" /listShort="cotI, ytaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2786379..2786398 /Source="Nicolas_upshift_promotors" /id="U2396" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1346 /SigmaFactorBS="aacaaccagattcatctattaaatatagtcaaataACTCAAT CATtttttccttttgaTTCATAAGGTAGGAGTAAAAcaggtaaggatgtgtcctttaa t" /listShort="cotI, ytaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2786381 /Source="Nicolas_upshifts" /id="U2396" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1346 /SigmaFactorBS="aacaaccagattcatctattaaatatagtcaaataACTCAAT CATtttttccttttgaTTCATAAGGTAGGAGTAAAAcaggtaaggatgtgtcctttaa t" /listShort="cotI, ytaB" /GFF_Attribute="listLong" /label="upshifts" CDS 2786408..2787481 /gene="cotI" /locus_tag="BSU_30920" /old_locus_tag="BSU30920" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12562816, 20077512" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562816, 20077512; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore coat kinase" /protein_id="NP_390970.1" /db_xref="EnsemblGenomes-Gn:BSU30920" /db_xref="EnsemblGenomes-Tr:CAB15070" /db_xref="GOA:O34656" /db_xref="InterPro:IPR002575" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR014255" /db_xref="PDB:2Q83" /db_xref="SubtiList:BG13821" /db_xref="UniProtKB/Swiss-Prot:O34656" /translation="MCPLMAENHEVIEEGNSSELPLSAEDAKKLTELAENVLQGWDVQ AEKIDVIQGNQMALVWKVHTDSGAVCLKRIHRPEKKALFSIFAQDYLAKKGMNVPGIL PNKKGSLYSKHGSFLFVVYDWIEGRPFELTVKQDLEFIMKGLADFHTASVGYQPPNGV PIFTKLGRWPNHYTKRCKQMETWKLMAEAEKEDPFSQLYLQEIDGFIEDGLRIKDRLL QSTYVPWTEQLKKSPNLCHQDYGTGNTLLGENEQIWVIDLDTVSFDLPIRDLRKMIIP LLDTTGVWDDETFNVMLNAYESRAPLTEEQKQVMFIDMLFPYELYDVIREKYVRKSAL PKEELESAFEYERIKANALRQLI*" /label="cotI CDS" gene 2786408..2787481 /gene="cotI" /locus_tag="BSU_30920" /old_locus_tag="BSU30920" /label="cotI gene" promotor_-35 2786705..2786711 /Source="Nicolas_upshift_promotors" /id="U2397" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=785 /SigmaFactorBS="tttcgcgcaggactatttagcaaaaaaaggcatgaatgttcc tGGCATACtcccaaacaaaaaAGGCAGCCTATAttctaagcacggctcatttctattt g" /listShort="ytaB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2786722 /Source="Nicolas_upshifts" /id="U2397" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=785 /SigmaFactorBS="tttcgcgcaggactatttagcaaaaaaaggcatgaatgttcc tGGCATACtcccaaacaaaaaAGGCAGCCTATAttctaagcacggctcatttctattt g" /listShort="ytaB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2786725..2786736 /Source="Nicolas_upshift_promotors" /id="U2397" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=785 /SigmaFactorBS="tttcgcgcaggactatttagcaaaaaaaggcatgaatgttcc tGGCATACtcccaaacaaaaaAGGCAGCCTATAttctaagcacggctcatttctattt g" /listShort="ytaB" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 2787470 /Source="Nicolas_upshifts" /id="D1591" /incds=0 /nref=16 /ntot=35 /MaxReadThrough="3.14769" /MaxDrop="5.1897" /score="-2.47616606" /energy="-10.3" /TU="U2396,U2397" /idTUdmin="U2396" /TUdmin="-528" /isTUend="FALSE" /label="downshifts" promotor_-35 2787508..2787514 /Source="Nicolas_upshift_promotors" /id="U2398" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=240 /SigmaFactorBS="gcagcttatttaagaccatcatttcccccgcatatcgggGGT TTGAtatttataagataaaGGGTAATTAAATACATGCGgaggttgcaaatatgaaaaa g" /listShort="ytaB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2787529 /Source="Nicolas_upshifts" /id="U2398" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=240 /SigmaFactorBS="gcagcttatttaagaccatcatttcccccgcatatcgggGGT TTGAtatttataagataaaGGGTAATTAAATACATGCGgaggttgcaaatatgaaaaa g" /listShort="ytaB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2787530..2787548 /Source="Nicolas_upshift_promotors" /id="U2398" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=240 /SigmaFactorBS="gcagcttatttaagaccatcatttcccccgcatatcgggGGT TTGAtatttataagataaaGGGTAATTAAATACATGCGgaggttgcaaatatgaaaaa g" /listShort="ytaB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2787561..2788028 /gene="ytaB" /locus_tag="BSU_30930" /old_locus_tag="BSU30930" /function="16.12: Sense" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11717291, 15849754, 16850406; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="putative receptor" /protein_id="NP_390971.1" /db_xref="EnsemblGenomes-Gn:BSU30930" /db_xref="EnsemblGenomes-Tr:CAB15071" /db_xref="GOA:O34694" /db_xref="InterPro:IPR004307" /db_xref="SubtiList:BG13822" /db_xref="UniProtKB/Swiss-Prot:O34694" /translation="MKKIVGALAVFVITYALFSAAGYLFPVDQEWYNSLKKPDWTPSG TAIGIIWAILFALISLSAAIVYAAFSFKGAKSFWFTLLINYVLNQAFSYFQFTQKNLL AASLDCLLVAITAIVLLIIAKKYSRAASYLLLPYFLWSAFATFLSFTINSMNL*" /label="ytaB CDS" gene 2787561..2788028 /gene="ytaB" /locus_tag="BSU_30930" /old_locus_tag="BSU30930" /label="ytaB gene" downshifts 2788000 /Source="Nicolas_upshifts" /id="D1592" /incds=0 /nref=43 /ntot=123 /MaxReadThrough="2.47485" /MaxDrop="5.7907" /score="9.10214462" /energy="-10.1" /TU="NA" /idTUdmin="U2396" /TUdmin=2 /isTUend="TRUE" /label="downshifts" CDS complement(2788059..2790455) /gene="glgP" /locus_tag="BSU_30940" /old_locus_tag="BSU30940" /EC_number="2.4.1.1" /function="16.14: Store" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 8145641, 9244254, 15272305; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycogen phosphorylase" /protein_id="NP_390972.1" /db_xref="EnsemblGenomes-Gn:BSU30940" /db_xref="EnsemblGenomes-Tr:CAB15072" /db_xref="GOA:P39123" /db_xref="InterPro:IPR000811" /db_xref="InterPro:IPR011833" /db_xref="InterPro:IPR035090" /db_xref="SubtiList:BG10911" /db_xref="UniProtKB/Swiss-Prot:P39123" /translation="MFSSKERFADLFLKRLEMTCGKSFKDSAKLDQYKTLGNMVREYI SADWIETNEKSRSNSGKQTYYLSIEFLLGQLLEQNLMNLGVRDVVEAGLKEIGINLEE ILQIENDAGLGNGGLGRLAACFLDSLASLNLPGHGMGIRYKHGLFEQKIVDGHQVELP EQWLKNGNVWEVRNADQAVDVPFWGEVHMTEKSGRLHFRHEQATIVTAVPYDIPIIGY ETGTVNTLRLWNAEPYAHYHGGNILSYKRETEAVSEFLYPDDTHDEGKILRLKQQYFL VCASLKSIVNNYRKTHKSLSGLHKKVSIHINDTHPALAVPELMRILLDEENMSWEEAW HITVHTISYTNHTTLSEALEKWPIHLFKPLLPRMYMIIEEINERFCRAVWEKYPGDWK RIENMAITAHGVVKMAHLAIVGSYSVNGVAKIHSDILKEREMRDFHLLFPNRFNNKTN GIAHRRWLLKANPGLSAIITEAIGDEWVKQPESLIRLEPYATDPAFIEQFQNNKSKKK QELADLIFCTAGVVVNPESIFDVQVKRLHAYKRQLLNVLHIMYLYNRLKEDSGFSIYP QTFIFGAKASPSYYYAKKIIKLIHSVAEKVNYDPAVKQLIKVVFLENYRVSMAERIFP ASDVSEQISTASKEASGTGNMKFMMNGALTIGTHDGANIEILERVGPDCIYTFGLKAD EVLSYQENGGYRSREYYQHDRRIRQVADQLINGFFEGEADEFESIFDSLLPHNDEYFV LKDFSSYADAQERIQADYRERRKWSEHSIVNIAHSGYFSSDRTIREYAKDIWGIKPMM *" /label="glgP CDS" gene complement(2788059..2790455) /gene="glgP" /locus_tag="BSU_30940" /old_locus_tag="BSU30940" /label="glgP gene" downshifts complement(2788074) /Source="Nicolas_upshifts" /id="D1593" /incds=0 /nref=6 /ntot=43 /MaxReadThrough="2.31076" /MaxDrop="4.39135" /score="34.694666" /energy="-10.1" /TU="NA" /idTUdmin="U2399" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2790442..2791896) /gene="glgA" /locus_tag="BSU_30950" /old_locus_tag="BSU30950" /EC_number="2.4.1.21" /function="16.14: Store" /experiment="publication(s) with functional evidences, PMID:8145641, 15272305" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8145641, 15272305; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycogen (starch) synthase" /protein_id="NP_390973.1" /db_xref="EnsemblGenomes-Gn:BSU30950" /db_xref="EnsemblGenomes-Tr:CAB15073" /db_xref="GOA:P39125" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR011835" /db_xref="InterPro:IPR013534" /db_xref="SubtiList:BG10910" /db_xref="UniProtKB/Swiss-Prot:P39125" /translation="MKILFAVSECTPFVKSGGLADVAGALPKALARLGNEVAVMLPKY SQIPEPWKKRMKKQAECTVAVGWRQQYCGIEHMAENDVNYYFIDNEYYFNRDSLYGHY DDGERFAFFSRAVLEAAKVVNVQADIVHTHDWHTAMVNYLLKEEYRKHPFYERMKSVL TIHNLQFQGIFPPDVTHDLLGLEMDHFHYERLECNGFVNFMKAGIIAADHVTTVSPTY RNEIMTPYYGEQLEQVLQYREDDVTGILNGIDDTFYQPKSDPYIEAQYDSGDLACKLE NKTKLQQRMGLPEKNDIPLISMVTRLTKQKGLDLVRRIMHELLEEQDIQLVVLGTGER EFEDYFRYAEFAFHEKCRAYIGFDEPLAHQIYAGSDMFLMPSKFEPCGLGQLIALQYG AIPIVRETGGLYDTVRAYQEEEGTGNGFTFSAFNAHDLKFTIERALSFYCQQDVWKSI VKTAMNADYSWGKSAKEYQRIFEQVTRSGRDVLE*" /label="glgA CDS" gene complement(2790442..2791896) /gene="glgA" /locus_tag="BSU_30950" /old_locus_tag="BSU30950" /label="glgA gene" CDS complement(2791893..2792924) /gene="glgD" /locus_tag="BSU_30960" /old_locus_tag="BSU30960" /EC_number="2.7.7.27" /function="16.14: Store" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8145641, 9244254; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucose-1-phosphate adenylyltransferase (ADP-glucose pyrophosphorylase) beta subunit" /protein_id="NP_390974.1" /db_xref="EnsemblGenomes-Gn:BSU30960" /db_xref="EnsemblGenomes-Tr:CAB15074" /db_xref="GOA:P39124" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR011004" /db_xref="InterPro:IPR011832" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10909" /db_xref="UniProtKB/Swiss-Prot:P39124" /translation="MFNNQMLGVIDETTYKHSLQDLTAQRSLGAIPFAGRYRLIDFML SNMVNADIRSVAIFPKYRYRSLMDHLGAGKEWDLHRKKDGLFFFPSPHLHHEYDEFGS FRQFSDHLDYFHRSTQQYAVISNSHTVCNIQFQYVLKRHQEVGCDVTEVFQDGQSLQI YIMSTTLLKDLIYGHSEKGYKTIQEAVEKESSALTICPYEYSGYAAVIDSVEKYYTHS MELIQPRFWQQVFLPQQPIYTKVKDEPPTKYGKHSTVKNSLVANGCVLEGEVENCILF RAVHVGKGTKLKNCIIMQKTQIGEDCLLEQVISDKDVKIGKATEAAGTAEQPLVLRKG LVQGELMNS*" /label="glgD CDS" gene complement(2791893..2792924) /gene="glgD" /locus_tag="BSU_30960" /old_locus_tag="BSU30960" /label="glgD gene" CDS complement(2792948..2794090) /gene="glgC" /locus_tag="BSU_30970" /old_locus_tag="BSU30970" /EC_number="2.7.7.27" /function="16.14: Store" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8145641, 9244254; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucose-1-phosphate adenylyltransferase (ADP-glucose pyrophosphorylase) subunit alpha" /protein_id="NP_390975.1" /db_xref="EnsemblGenomes-Gn:BSU30970" /db_xref="EnsemblGenomes-Tr:CAB15075" /db_xref="GOA:P39122" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR005836" /db_xref="InterPro:IPR011004" /db_xref="InterPro:IPR011831" /db_xref="InterPro:IPR023049" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10908" /db_xref="UniProtKB/Swiss-Prot:P39122" /translation="MKKQCVAMLLAGGKGSRLSGLTKNMAKPAVSFGGKYRIIDFTLS NCSNSGIDTVGILTQYQPLELNSYIGIGSAWDLDRYNGGVTVLPPYAESSEVKWYKGT ASSIYENLNYLNQYDPEYVLILSGDHIYKMDYGKMLDYHIEKKADVTISVIEVGWEEA SRFGIMKANPDGTITHFDEKPKFPKSNLASMGIYIFNWPLLKQYLEMDDQNPYSSHDF GKDIIPLLLEEKKKLSAYPFKGYWKDVGTVQSLWEANMDLLKEDSELKLFERKWKIYS VNPNQPPQFISSDAQVQDSLVNEGCVVYGNVSHSVLFQGVTVGKHTTVTSSVIMPDVT IGEHVVIENAIVPNGMVLPDGAVIRSEKDIEEVLLVSEEFVEKELI*" /label="glgC CDS" gene complement(2792948..2794090) /gene="glgC" /locus_tag="BSU_30970" /old_locus_tag="BSU30970" /label="glgC gene" CDS complement(2794087..2795970) /gene="glgB" /locus_tag="BSU_30980" /old_locus_tag="BSU30980" /EC_number="2.4.1.18" /function="16.14: Store" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1296817, 15272305, 8145641; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="1,4-alpha-glucan branching enzyme" /protein_id="NP_390976.1" /db_xref="EnsemblGenomes-Gn:BSU30980" /db_xref="EnsemblGenomes-Tr:CAB15076" /db_xref="GOA:P39118" /db_xref="InterPro:IPR004193" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR006048" /db_xref="InterPro:IPR006407" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR014756" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG10907" /db_xref="UniProtKB/Swiss-Prot:P39118" /translation="MAAASPTAHDVYLFHEGSLFKSYQLFGSHYRELNGKSGYEFCVW APHASEVRVAGDFNSWSGEEHVMHRVNDNGIWTLFIPGIGEKERYKYEIVTNNGEIRL KADPYAIYSEVRPNTASLTYDLEGYSWQDQKWQKKQKAKTLYEKPVFIYELHLGSWKK HSDGRHYSYKELSQTLIPYIKKHGFTHIELLPVYEHPYDRSWGYQGTGYYSPTSRFGP PHDLMKFVDECHQQNIGVILDWVPGHFCKDAHGLYMFDGEPLYEYKEERDRENWLWGT ANFDLGKPEVHSFLISNALYWAEFYHIDGFRVDAVANILYWPNQDERHTNPYAVDFLK KLNQTMREAYPHVMMIAEDSTEWPQVTGAVEEGGLGFHYKWNMGWMNDVLKYMETPPE ERRHCHQLISFSLLYAFSEHFVLPFSHDEVVYGKKSLLNKMPGDYWQKFAQYRLLLGY MTVHPGKKLIFMGSEFAQFDEWKDTEQLDWFLDSFPMHQKASVFTQDLLRFYQKSKIL YEHDHRAQSFEWIDVHNDEQSIFSFIRYGQKHGEALVIICNFTPVVYHQYDVGVPFFT QYIEVLNSDSETYGGSGQINKKPLSAKKGALHHKPCYITMTIPPYGISILRAVKKRGE IKR*" /label="glgB CDS" gene complement(2794087..2795970) /gene="glgB" /locus_tag="BSU_30980" /old_locus_tag="BSU30980" /label="glgB gene" S_feature 2794796..2796215 /Source="Nicolas_S_feature" /locus_tag="new_3170472_3171891" /HighExp="S8, S7, S6, C30, BT, Pyr, G/S, S2, C90, BC" /AntisenseName="glgB" /AntisenseCor="0.59299722159013002" /AntisenseRegPval="-26.2" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1180" promotor_-10 complement(2796002..2796017) /Source="Nicolas_upshift_promotors" /id="U2399" /multdbtbs="SigE" /comp="M1" /sig="Sig-" /pcomp="0.414585414585415" /psig="0.414585414585415" /xcortree=1175 /SigmaFactorBS="gaagttaattgtctataagtataagcgctttcaggaaaGGGC TTttttttatttcttcGAATAAATACTATAAAtgaaaactatgatgtcagaaaggatg a" /listShort="glgB, glgC, glgD, glgA, glgP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2796015) /Source="Nicolas_upshifts" /id="U2399" /multdbtbs="SigE" /comp="M1" /sig="Sig-" /pcomp="0.414585414585415" /psig="0.414585414585415" /xcortree=1175 /SigmaFactorBS="gaagttaattgtctataagtataagcgctttcaggaaaGGGC TTttttttatttcttcGAATAAATACTATAAAtgaaaactatgatgtcagaaaggatg a" /listShort="glgB, glgC, glgD, glgA, glgP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2796032..2796037) /Source="Nicolas_upshift_promotors" /id="U2399" /multdbtbs="SigE" /comp="M1" /sig="Sig-" /pcomp="0.414585414585415" /psig="0.414585414585415" /xcortree=1175 /SigmaFactorBS="gaagttaattgtctataagtataagcgctttcaggaaaGGGC TTttttttatttcttcGAATAAATACTATAAAtgaaaactatgatgtcagaaaggatg a" /listShort="glgB, glgC, glgD, glgA, glgP" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2796082) /Source="Nicolas_upshifts" /id="D1594" /incds=0 /nref=2 /ntot=46 /MaxReadThrough="1.66182" /MaxDrop="3.12741" /score="36.0363304" /energy="-9.2" /TU="NA" /idTUdmin="U2401" /TUdmin=198 /isTUend="FALSE" /label="downshifts" tRNA complement(2796203..2796274) /gene="trnB-Glu" /locus_tag="BSU_tRNA_72" /product="tRNA-Glu" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Glu tRNA" gene complement(2796203..2796274) /gene="trnB-Glu" /locus_tag="BSU_tRNA_72" /label="trnB-Glu gene" tRNA complement(2796300..2796390) /gene="trnB-Ser2" /locus_tag="BSU_tRNA_71" /product="tRNA-Ser" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Ser2 tRNA" gene complement(2796300..2796390) /gene="trnB-Ser2" /locus_tag="BSU_tRNA_71" /label="trnB-Ser2 gene" tRNA complement(2796394..2796468) /gene="trnB-Asn" /locus_tag="BSU_tRNA_70" /product="tRNA-Asn" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Asn tRNA" gene complement(2796394..2796468) /gene="trnB-Asn" /locus_tag="BSU_tRNA_70" /label="trnB-Asn gene" tRNA complement(2796479..2796555) /gene="trnB-Ile2" /locus_tag="BSU_tRNA_69" /product="tRNA-Ile" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Ile2 tRNA" gene complement(2796479..2796555) /gene="trnB-Ile2" /locus_tag="BSU_tRNA_69" /label="trnB-Ile2 gene" tRNA complement(2796571..2796644) /gene="trnB-Gly2" /locus_tag="BSU_tRNA_68" /product="tRNA-Gly" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Gly2 tRNA" gene complement(2796571..2796644) /gene="trnB-Gly2" /locus_tag="BSU_tRNA_68" /label="trnB-Gly2 gene" tRNA complement(2796655..2796730) /gene="trnB-His" /locus_tag="BSU_tRNA_67" /product="tRNA-His" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-His tRNA" gene complement(2796655..2796730) /gene="trnB-His" /locus_tag="BSU_tRNA_67" /label="trnB-His gene" tRNA complement(2796748..2796823) /gene="trnB-Phe" /locus_tag="BSU_tRNA_66" /product="tRNA-Phe" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Phe tRNA" gene complement(2796748..2796823) /gene="trnB-Phe" /locus_tag="BSU_tRNA_66" /label="trnB-Phe gene" tRNA complement(2796836..2796912) /gene="trnB-Asp" /locus_tag="BSU_tRNA_65" /product="tRNA-Asp" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Asp tRNA" gene complement(2796836..2796912) /gene="trnB-Asp" /locus_tag="BSU_tRNA_65" /label="trnB-Asp gene" tRNA complement(2796924..2797000) /gene="trnB-Met2" /locus_tag="BSU_tRNA_64" /product="tRNA-Met" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Met2 tRNA" gene complement(2796924..2797000) /gene="trnB-Met2" /locus_tag="BSU_tRNA_64" /label="trnB-Met2 gene" tRNA complement(2797018..2797110) /gene="trnB-Ser1" /locus_tag="BSU_tRNA_63" /product="tRNA-Ser" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Ser1 tRNA" gene complement(2797018..2797110) /gene="trnB-Ser1" /locus_tag="BSU_tRNA_63" /label="trnB-Ser1 gene" tRNA complement(2797117..2797193) /gene="trnB-Met3" /locus_tag="BSU_tRNA_62" /product="tRNA-Met" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Met3 tRNA" gene complement(2797117..2797193) /gene="trnB-Met3" /locus_tag="BSU_tRNA_62" /label="trnB-Met3 gene" tRNA complement(2797196..2797272) /gene="trnB-Met1" /locus_tag="BSU_tRNA_61" /product="tRNA-Met" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Met1 tRNA" gene complement(2797196..2797272) /gene="trnB-Met1" /locus_tag="BSU_tRNA_61" /label="trnB-Met1 gene" tRNA complement(2797292..2797364) /gene="trnB-Ala" /locus_tag="BSU_tRNA_60" /product="tRNA-Ala" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Ala tRNA" gene complement(2797292..2797364) /gene="trnB-Ala" /locus_tag="BSU_tRNA_60" /label="trnB-Ala gene" tRNA complement(2797370..2797446) /gene="trnB-Pro" /locus_tag="BSU_tRNA_59" /product="tRNA-Pro" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Pro tRNA" gene complement(2797370..2797446) /gene="trnB-Pro" /locus_tag="BSU_tRNA_59" /label="trnB-Pro gene" tRNA complement(2797462..2797538) /gene="trnB-Arg" /locus_tag="BSU_tRNA_58" /product="tRNA-Arg" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Arg tRNA" gene complement(2797462..2797538) /gene="trnB-Arg" /locus_tag="BSU_tRNA_58" /label="trnB-Arg gene" tRNA complement(2797548..2797633) /gene="trnB-Leu2" /locus_tag="BSU_tRNA_57" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Leu2 tRNA" gene complement(2797548..2797633) /gene="trnB-Leu2" /locus_tag="BSU_tRNA_57" /label="trnB-Leu2 gene" tRNA complement(2797648..2797722) /gene="trnB-Gly1" /locus_tag="BSU_tRNA_56" /product="tRNA-Gly" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Gly1 tRNA" gene complement(2797648..2797722) /gene="trnB-Gly1" /locus_tag="BSU_tRNA_56" /label="trnB-Gly1 gene" tRNA complement(2797728..2797814) /gene="trnB-Leu1" /locus_tag="BSU_tRNA_55" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Leu1 tRNA" gene complement(2797728..2797814) /gene="trnB-Leu1" /locus_tag="BSU_tRNA_55" /label="trnB-Leu1 gene" tRNA complement(2797825..2797900) /gene="trnB-Lys" /locus_tag="BSU_tRNA_54" /product="tRNA-Lys" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Lys tRNA" gene complement(2797825..2797900) /gene="trnB-Lys" /locus_tag="BSU_tRNA_54" /label="trnB-Lys gene" tRNA complement(2797938..2798013) /gene="trnB-Thr" /locus_tag="BSU_tRNA_53" /product="tRNA-Thr" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Thr tRNA" gene complement(2797938..2798013) /gene="trnB-Thr" /locus_tag="BSU_tRNA_53" /label="trnB-Thr gene" tRNA complement(2798046..2798121) /gene="trnB-Val" /locus_tag="BSU_tRNA_52" /product="tRNA-Val" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Val tRNA" gene complement(2798046..2798121) /gene="trnB-Val" /locus_tag="BSU_tRNA_52" /label="trnB-Val gene" rRNA complement(2798142..2798259) /gene="rrnB-5S" /locus_tag="BSU_rRNA_21" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnB-5S rRNA" gene complement(2798142..2798259) /gene="rrnB-5S" /locus_tag="BSU_rRNA_21" /label="rrnB-5S gene" rRNA complement(2798315..2801242) /gene="rrnB-23S" /locus_tag="BSU_rRNA_20" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnB-23S rRNA" gene complement(2798315..2801242) /gene="rrnB-23S" /locus_tag="BSU_rRNA_20" /label="rrnB-23S gene" rRNA complement(2801410..2802964) /gene="rrnB-16S" /locus_tag="BSU_rRNA_19" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnB-16S rRNA" gene complement(2801410..2802964) /gene="rrnB-16S" /locus_tag="BSU_rRNA_19" /label="rrnB-16S gene" Polymorphism join(2802766,2802768) /Source="geneious" /ID="SNP_BsDelta6_3178443_3178443" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change /CDS_Position /Change="T -> C" /Codon_Change /Coverage=95 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides="C" /Variant_P_Value="3.5e-102" /Variant_Raw_Frequency=94 /comment="rrnB-16S rRNA" /modified_by="User" / /label="Polymorphism_Delta6" S_feature complement(2802965..2803256) /Source="Nicolas_S_feature" /locus_tag="new_3178641_3178932_c" /HighExp="Diami, LPhT, C30, LBGstat, HPh, GM 120, Oxctl, Paraq, LPh, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.40784100000000001" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigWXY" /TUlongPSig=1 /label="S1181" misc_feature 2803092..2803100 /Source="Nicolas_upshift_promotors" /id="U2400" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.413586413586414" /psig="0.320679320679321" /xcortree=710 /SigmaFactorBS="tgactacgcacatcgcagtgcgatttttaaaaactgaattaa caggtacgttttGTCTTGTTTagttttcaaagatcatttcgttacttctcaatgaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2803098 /Source="Nicolas_upshifts" /id="U2400" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.413586413586414" /psig="0.320679320679321" /xcortree=710 /SigmaFactorBS="tgactacgcacatcgcagtgcgatttttaaaaactgaattaa caggtacgttttGTCTTGTTTagttttcaaagatcatttcgttacttctcaatgaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2803208 /Source="Nicolas_upshifts" /id="D1595" /incds=0 /nref=2 /ntot=26 /MaxReadThrough="2.91899" /MaxDrop="4.63941" /score="-0.368124787" /energy="-10.2" /TU="U2400" /idTUdmin="U2400" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2803229..2803248) /Source="Nicolas_upshift_promotors" /id="U2401" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2621 /SigmaFactorBS="ggcgaggattatagtttatttgttttatagattttttttaaa aaactATTGCAATaaataaatacaggTGTTATATTATTAAACGTCGctgatgcacagc g" /listShort="S1181, rrnB-16S, rrnB-23S, rrnB-5S, trnB-Val, trnB-Thr, trnB-Lys, trnB-Leu1, trnB-Gly1, trnB-Leu2, trnB-Arg, trnB-Pro, trnB-Ala, trnB-Met1, trnB-Met3, trnB-Ser1, trnB-Met2, trnB-Asp, trnB-Phe, trnB-His, trnB-Gly2, trnB-Ile2, trnB-Asn, trnB-Ser2" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2803256) /Source="Nicolas_upshifts" /id="U2401" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2621 /SigmaFactorBS="ggcgaggattatagtttatttgttttatagattttttttaaa aaactATTGCAATaaataaatacaggTGTTATATTATTAAACGTCGctgatgcacagc g" /listShort="S1181, rrnB-16S, rrnB-23S, rrnB-5S, trnB-Val, trnB-Thr, trnB-Lys, trnB-Leu1, trnB-Gly1, trnB-Leu2, trnB-Arg, trnB-Pro, trnB-Ala, trnB-Met1, trnB-Met3, trnB-Ser1, trnB-Met2, trnB-Asp, trnB-Phe, trnB-His, trnB-Gly2, trnB-Ile2, trnB-Asn, trnB-Ser2" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2803258..2804224) /Source="Nicolas_S_feature" /locus_tag="new_3178934_3179900_c" /HighExp="T1.0H, T0.30H, T1.30H, T2.0H, T2.30H, T0.0H, T3.0H, T-0.40H, S8, T3.30H" /AntisenseName="thiT" /AntisenseCor="-0.219467435413819" /AntisenseRegPval="-3.5" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1182" promotor_-35 complement(2803262..2803269) /Source="Nicolas_upshift_promotors" /id="U2401" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2621 /SigmaFactorBS="ggcgaggattatagtttatttgttttatagattttttttaaa aaactATTGCAATaaataaatacaggTGTTATATTATTAAACGTCGctgatgcacagc g" /listShort="S1181, rrnB-16S, rrnB-23S, rrnB-5S, trnB-Val, trnB-Thr, trnB-Lys, trnB-Leu1, trnB-Gly1, trnB-Leu2, trnB-Arg, trnB-Pro, trnB-Ala, trnB-Met1, trnB-Met3, trnB-Ser1, trnB-Met2, trnB-Asp, trnB-Phe, trnB-His, trnB-Gly2, trnB-Ile2, trnB-Asn, trnB-Ser2" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2803381..2803384 /Source="Nicolas_upshift_promotors" /id="U2402" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=1747 /SigmaFactorBS="tatcatataagtttcttaaaagaacatatacatcagtcatgt gatCTTGttgtttttttcgttTTCTTGTATAGTAGAAACGAactaaatactgatgacc a" /listShort="NA, thiT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2803396 /Source="Nicolas_upshifts" /id="U2402" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=1747 /SigmaFactorBS="tatcatataagtttcttaaaagaacatatacatcagtcatgt gatCTTGttgtttttttcgttTTCTTGTATAGTAGAAACGAactaaatactgatgacc a" /listShort="NA, thiT" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2803399..2803418 /Source="Nicolas_upshift_promotors" /id="U2402" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=1747 /SigmaFactorBS="tatcatataagtttcttaaaagaacatatacatcagtcatgt gatCTTGttgtttttttcgttTTCTTGTATAGTAGAAACGAactaaatactgatgacc a" /listShort="NA, thiT" /GFF_Attribute="listLong" /label="promotor_-10" misc_RNA 2803429..2803530 /gene="tswC" /locus_tag="BSU_misc_RNA_51" /product="thiamine pyrophosphate riboswitch" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11470904, 12410317, 15862294, 16728979, 16962976, 17307816, 18179415, 18776013; Product type n: RNA" /function="16.3: Control" /label="tswC RNA" gene 2803429..2803530 /gene="tswC" /locus_tag="BSU_misc_RNA_51" /label="tswC gene" downshifts 2803529 /Source="Nicolas_upshifts" /id="D1596" /incds=0 /nref=47 /ntot=135 /MaxReadThrough="5.85975" /MaxDrop="7.03111" /score="-0.368124787" /energy="-10.2" /TU="U2402" /idTUdmin="U2400" /TUdmin=299 /isTUend="FALSE" /label="downshifts" CDS 2803630..2804208 /gene="thiT" /locus_tag="BSU_30990" /old_locus_tag="BSU30990" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16291685, 16356850, 16850406, 19181806" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16291685, 16356850, 16850406, 19181806; Product type t : transporter" /codon_start=1 /transl_table=11 /product="thiamin permease" /protein_id="NP_390977.1" /db_xref="EnsemblGenomes-Gn:BSU30990" /db_xref="EnsemblGenomes-Tr:CAB15077" /db_xref="GOA:O32074" /db_xref="InterPro:IPR012651" /db_xref="SubtiList:BG13949" /db_xref="UniProtKB/Swiss-Prot:O32074" /translation="MNQSKQLVRLIEIAIMTAAAVILDIVSGMFLSMPQGGSVSIMMI PIFLISFRWGVKAGLTTGLLTGLVQIAIGNLFAQHPVQLLLDYIVAFAAIGISGCFAS SVRKAAVSKTKGKLIVSVVSAVFIGSLLRYAAHVISGAVFFGSFAPKGTPVWIYSLTY NATYMVPSFIICAIVLCLLFMTAPRLLKSDKA*" /label="thiT CDS" gene 2803630..2804208 /gene="thiT" /locus_tag="BSU_30990" /old_locus_tag="BSU30990" /label="thiT gene" downshifts 2804198 /Source="Nicolas_upshifts" /id="D1597" /incds=0 /nref=129 /ntot=206 /MaxReadThrough="1.91553" /MaxDrop="5.49387" /score="35.5376279" /energy="-19.5" /TU="NA" /idTUdmin="U2402" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2804250..2804771) /gene="yuaI" /locus_tag="BSU_31000" /old_locus_tag="BSU31000" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_390978.1" /db_xref="EnsemblGenomes-Gn:BSU31000" /db_xref="EnsemblGenomes-Tr:CAB15078" /db_xref="GOA:O32075" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13948" /db_xref="UniProtKB/Swiss-Prot:O32075" /translation="MVTVREAKLEDIKDIAKVHVDSWRTTYHEIIPIDYLNSLNYKEF EDKWKSRSLKGVFVAQDEKGSVFGFASFGPIRSEQEGYDGELYAIYLLEERQRQGAGR ALLAKGAEFLLQHGFSSMFVWVIEQNPSIIFYQAYSPERVAEDNFEIAGVRLKEVGLG WPDLSALKTLLNR*" /label="yuaI CDS" gene complement(2804250..2804771) /gene="yuaI" /locus_tag="BSU_31000" /old_locus_tag="BSU31000" /label="yuaI gene" downshifts complement(2804268) /Source="Nicolas_upshifts" /id="D1598" /incds=0 /nref=8 /ntot=143 /MaxReadThrough="6.18352" /MaxDrop="5.43101" /score="13.1646679" /energy="-19.6" /TU="U2403" /idTUdmin="U2405" /TUdmin=6 /isTUend="TRUE" /label="downshifts" downshifts complement(2804340) /Source="Nicolas_upshifts" /id="D1599" /incds=1 /nref=8 /ntot=208 /MaxReadThrough="8.2849" /MaxDrop="3.3545" /score="13.1646679" /energy="-19.6" /TU="U2403,U2405" /idTUdmin="U2405" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" CDS complement(2804789..2806318) /gene="floT" /locus_tag="BSU_31010" /old_locus_tag="BSU31010" /experiment="publication(s) with functional evidences, PMID:9153235, 9987136, 12533473, 17482313, 19383680, 25635948, 26297017, 28681845" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9153235, 9987136, 12533473, 17482313, 19383680, 25635948, 26297017, 28681845; Product type s: structure" /codon_start=1 /transl_table=11 /product="flotillin lipid rafts scaffold protein" /protein_id="NP_390979.1" /db_xref="EnsemblGenomes-Gn:BSU31010" /db_xref="EnsemblGenomes-Tr:CAB15079" /db_xref="GOA:O32076" /db_xref="InterPro:IPR001107" /db_xref="InterPro:IPR027705" /db_xref="InterPro:IPR031905" /db_xref="InterPro:IPR036013" /db_xref="SubtiList:BG13947" /db_xref="UniProtKB/Swiss-Prot:O32076" /translation="MTMPIIMIIGVVFFLLIALIAVFITKYRTAGPDEALIVTGSYLG NKNVHVDEGGNRIKIVRGGGTFVLPVFQQAEPLSLLSSKLDVSTPEVYTEQGVPVMAD GTAIIKIGGSIGEIATAAEQFLGKSKDDREQEAREVLEGHLRSILGSMTVEEIYKNRE KFSQEVQRVASQDLAKMGLVIVSFTIKDVRDKNGYLESLGKPRIAQVKRDADIATAEA DKETRIKRAEADKDAKKSELERATEIAEAEKINQLKMAEFRREQDTAKANADQAYDLE TARARQQVTEQEMQVKIIERQKQIELEEKEILRRERQYDSEVKKKADADRYSVEQSAA AEKAKQLAEADAKKYSIEAMAKAEAEKVRIDGLAKAEAEKAKGETEAEVIRLKGLAEA EAKEKIAAAFEQYGQAAIFDMIVKMLPEYAKQAAAPLSNIDKITVVDTGGSGESSGAN KVTSYATNLMSSLQESLKASSGIDVKEMLENFSGKGNVKQSINELTNEIKEAKTIQKS E*" /label="floT CDS" gene complement(2804789..2806318) /gene="floT" /locus_tag="BSU_31010" /old_locus_tag="BSU31010" /label="floT gene" CDS complement(2806339..2806863) /gene="nfeDB" /locus_tag="BSU_31020" /old_locus_tag="BSU31020" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12533473, 15849754, 16850406, 18696230, 22753055; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane integrity integral membrane protein" /protein_id="NP_390980.1" /db_xref="EnsemblGenomes-Gn:BSU31020" /db_xref="EnsemblGenomes-Tr:CAB15080" /db_xref="GOA:O32077" /db_xref="PDB:2K14" /db_xref="SubtiList:BG13946" /db_xref="UniProtKB/Swiss-Prot:O32077" /translation="MELFGVPIQTMYLYTLIIAGSLTLLFLFFGDVFSGLSEGIPFLN PTLVLSFFTCFSAGGYIGELVLPLSSLLIALLSCILSIMLVVLLHIFVLVPLSSAEES LAYREDDLRGRLGKVITAVPVDGFGEVVIEGIGGTISKSAVSFDNQQISYGTTVLVVD INNGVLSVTPHEPI*" /label="nfeDB CDS" gene complement(2806339..2806863) /gene="nfeDB" /locus_tag="BSU_31020" /old_locus_tag="BSU31020" /label="nfeDB gene" promotor_-10 complement(2806907..2806922) /Source="Nicolas_upshift_promotors" /id="U2403" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1691 /SigmaFactorBS="acttcaaatgggttatttgtcttaaaatttTGAAACTTTTcc cgaggtgtcTCGTATAAATGGTAACggcagccgttcatcaatgcattgatgaagaaag g" /listShort="yuaF, yuaG, yuaI, S1182" /listLong="S1181" /label="promotor_-10" upshifts complement(2806913) /Source="Nicolas_upshifts" /id="U2403" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1691 /SigmaFactorBS="acttcaaatgggttatttgtcttaaaatttTGAAACTTTTcc cgaggtgtcTCGTATAAATGGTAACggcagccgttcatcaatgcattgatgaagaaag g" /listShort="yuaF, yuaG, yuaI, S1182" /listLong="S1181" /label="upshifts" S_feature complement(2806915..2807002) /Source="Nicolas_S_feature" /locus_tag="new_3182591_3182678_c" /HighExp="S4, S8, S6, S7, S5, S3, B36, LoTm, B60, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.96" /TUlongSig="NA" /TUlongPSig="NA" /label="S1183" promotor_-35 complement(2806934..2806943) /Source="Nicolas_upshift_promotors" /id="U2403" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1691 /SigmaFactorBS="acttcaaatgggttatttgtcttaaaatttTGAAACTTTTcc cgaggtgtcTCGTATAAATGGTAACggcagccgttcatcaatgcattgatgaagaaag g" /listShort="yuaF, yuaG, yuaI, S1182" /listLong="S1181" /label="promotor_-35" promotor_-10 complement(2806987..2807005) /Source="Nicolas_upshift_promotors" /id="U2405" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=1070 /SigmaFactorBS="gtttctaatctggcttcattaaagatactcatcatatCTCCT CctaaaatgacattaCCATATATATAAGCAATTAtcatttataaagcacttcaaatgg g" /listShort="S1183, yuaF, yuaG, yuaI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2806997 /Source="Nicolas_upshifts" /id="U2404" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.442557442557443" /psig="0.962037962037962" /xcortree=633 /SigmaFactorBS="agtttcaaaattttaagacaaataacccatttgaagtgcttt ataaatgataattgcttatataTATGGTAATGTCATTTTAGGaggagatatgatgagt a" /listShort="yuaE, S1184" /GFF_Attribute="listLong" /label="upshifts" misc_feature 2807001..2807020 /Source="Nicolas_upshift_promotors" /id="U2404" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.442557442557443" /psig="0.962037962037962" /xcortree=633 /SigmaFactorBS="agtttcaaaattttaagacaaataacccatttgaagtgcttt ataaatgataattgcttatataTATGGTAATGTCATTTTAGGaggagatatgatgagt a" /listShort="yuaE, S1184" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2807002) /Source="Nicolas_upshifts" /id="U2405" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=1070 /SigmaFactorBS="gtttctaatctggcttcattaaagatactcatcatatCTCCT CctaaaatgacattaCCATATATATAAGCAATTAtcatttataaagcacttcaaatgg g" /listShort="S1183, yuaF, yuaG, yuaI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2807020..2807025) /Source="Nicolas_upshift_promotors" /id="U2405" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=1070 /SigmaFactorBS="gtttctaatctggcttcattaaagatactcatcatatCTCCT CctaaaatgacattaCCATATATATAAGCAATTAtcatttataaagcacttcaaatgg g" /listShort="S1183, yuaF, yuaG, yuaI" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2807031..2807519 /gene="yuaE" /locus_tag="BSU_31030" /old_locus_tag="BSU31030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390981.1" /db_xref="EnsemblGenomes-Gn:BSU31030" /db_xref="EnsemblGenomes-Tr:CAB15081" /db_xref="InterPro:IPR024775" /db_xref="InterPro:IPR034660" /db_xref="SubtiList:BG13945" /db_xref="UniProtKB/Swiss-Prot:O32078" /translation="MSIFNEARLETWNELKGLSDEKLNQKPSAEEWSIREVLDHLKKI DMTAQKMLKERVKDAPIKEIEEKPLEVAQDRNNKRKAPSHLEPAHDFISGSQMKRELD VVREQLTAAIASLKEEDFERVLPHPVFQELTVRQWIDFIGHHEKRHLSQMKEIKEKIE RA*" /label="yuaE CDS" gene 2807031..2807519 /gene="yuaE" /locus_tag="BSU_31030" /old_locus_tag="BSU31030" /label="yuaE gene" downshifts 2807496 /Source="Nicolas_upshifts" /id="D1600" /incds=0 /nref=205 /ntot=267 /MaxReadThrough="4.05856" /MaxDrop="6.05192" /score="-4.20632485" /energy="-15" /TU="U2404" /idTUdmin="U2404" /TUdmin="-354" /isTUend="FALSE" /label="downshifts" CDS complement(2807525..2808103) /gene="yuaD" /locus_tag="BSU_31040" /old_locus_tag="BSU31040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11886751" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390982.1" /db_xref="EnsemblGenomes-Gn:BSU31040" /db_xref="EnsemblGenomes-Tr:CAB15082" /db_xref="GOA:O32079" /db_xref="InterPro:IPR005302" /db_xref="InterPro:IPR011037" /db_xref="PDB:1ORU" /db_xref="SubtiList:BG13944" /db_xref="UniProtKB/Swiss-Prot:O32079" /translation="MWKRMTAKAEGLYIADTKSFVTKQMDKLDFDYGGIPGDLHFGLT KKAGAREPMFSRGTEIFNRRQISIVSIEECNEIALKMGVPRILPEWLGANVAVSGMPD LTSLKEGSRIIFPSGAALLCEGENDPCIQPGEVIQSYYPDQPKLASAFVRHALGIRGI VCIVERPGAVYTGDEIEVHSYQRKVKRKAERV*" /label="yuaD CDS" gene complement(2807525..2808103) /gene="yuaD" /locus_tag="BSU_31040" /old_locus_tag="BSU31040" /label="yuaD gene" S_feature 2807541..2807932 /Source="Nicolas_S_feature" /locus_tag="new_3183217_3183608" /HighExp="Etha, S8, LPhT, S6, Salt, LoTm, S5, H2O2, S7, dia5" /AntisenseName="yuaD" /AntisenseCor="-0.48344313728748101" /AntisenseRegPval="-16.399999999999999" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.962" /TUlongSig="NA" /TUlongPSig="NA" /label="S1184" downshifts complement(2807552) /Source="Nicolas_upshifts" /id="D1601" /incds=0 /nref=87 /ntot=222 /MaxReadThrough="0.58189" /MaxDrop="3.9885" /score="0.718873117" /energy="-11.5" /TU="NA" /idTUdmin="U2406" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2808137..2808156) /Source="Nicolas_upshift_promotors" /id="U2406" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.437562437562438" /psig="0.97902097902098" /xcortree=2148 /SigmaFactorBS="gcctaaaacggtataatcaaaatcccgctCCTTTACAgagcg ggatttttTGGGATAATGAAGCATAGGTggaaattttagataagaaggaaggtgccag c" /listShort="yuaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2808146) /Source="Nicolas_upshifts" /id="U2406" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.437562437562438" /psig="0.97902097902098" /xcortree=2148 /SigmaFactorBS="gcctaaaacggtataatcaaaatcccgctCCTTTACAgagcg ggatttttTGGGATAATGAAGCATAGGTggaaattttagataagaaggaaggtgccag c" /listShort="yuaD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2808170..2808177) /Source="Nicolas_upshift_promotors" /id="U2406" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.437562437562438" /psig="0.97902097902098" /xcortree=2148 /SigmaFactorBS="gcctaaaacggtataatcaaaatcccgctCCTTTACAgagcg ggatttttTGGGATAATGAAGCATAGGTggaaattttagataagaaggaaggtgccag c" /listShort="yuaD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2808191..2809399) /gene="gbsB" /locus_tag="BSU_31050" /old_locus_tag="BSU31050" /EC_number="1.1.99.1" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8752328, 22408163" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8752328, 22408163; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="choline dehydrogenase" /protein_id="NP_390983.2" /db_xref="EnsemblGenomes-Gn:BSU31050" /db_xref="EnsemblGenomes-Tr:CAB15083" /db_xref="GOA:P71017" /db_xref="InterPro:IPR001670" /db_xref="InterPro:IPR018211" /db_xref="SubtiList:BG11941" /db_xref="UniProtKB/Swiss-Prot:P71017" /translation="MTLNMKVESMQKFHTFEIPTVIKHGIGAIKHTGEEVAALGVSKA LLVTDPGIYKAGVADPVIESLKEAGIEVVLFNKVEPNPPVRLVNEGSELYKKENCNGL VAVGGGSSMDTAKAIGVEATHEGSVLDYEAADGKKPLENRIPPLTTIPTTAGTGSEVT QWAVITDEEREFKFNTGGPLIAAHLTIIDPELHVSMPPHVTAMTGIDALAHAIECYTM KFAQPITDAVALMAIEYAAHYIKRAFADGEDLEARYGMAQAAMLAGLSYGSESAGAAH AMSQTLGGIIPVAHGQCVAAMMGPVMEYNWKGYPEKFARIAKAFGIDTSKMTTEEAAK ASVNWMYDLVEDLEVPTLEEQGVSPDMIERLSKEAMKDPQTFGNPRDLNEKAYNWIYK RCFNLTPKTV*" /label="gbsB CDS" gene complement(2808191..2809399) /gene="gbsB" /locus_tag="BSU_31050" /old_locus_tag="BSU31050" /label="gbsB gene" downshifts complement(2808212) /Source="Nicolas_upshifts" /id="D1602" /incds=0 /nref=2 /ntot=70 /MaxReadThrough="2.9443" /MaxDrop="3.26923" /score="18.315772" /energy="-13.6" /TU="NA" /idTUdmin="U2406" /TUdmin="-660" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2809168..2809187) /Source="Nicolas_upshift_promotors" /id="U2407" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.66033966033966" /psig="0.983016983016983" /xcortree=2046 /SigmaFactorBS="aaagccggtgttgctgatcccgtaatcgaatCACTTAAAgaa gcaggcattgaAGTGGTACTCTTTAATAAAGttgagccaaacccgcctgtccgtctgg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2809180) /Source="Nicolas_upshifts" /id="U2407" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.66033966033966" /psig="0.983016983016983" /xcortree=2046 /SigmaFactorBS="aaagccggtgttgctgatcccgtaatcgaatCACTTAAAgaa gcaggcattgaAGTGGTACTCTTTAATAAAGttgagccaaacccgcctgtccgtctgg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2809202..2809209) /Source="Nicolas_upshift_promotors" /id="U2407" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.66033966033966" /psig="0.983016983016983" /xcortree=2046 /SigmaFactorBS="aaagccggtgttgctgatcccgtaatcgaatCACTTAAAgaa gcaggcattgaAGTGGTACTCTTTAATAAAGttgagccaaacccgcctgtccgtctgg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2809416..2810888) /gene="gbsA" /locus_tag="BSU_31060" /old_locus_tag="BSU31060" /EC_number="1.2.1.8" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8752328, 9297465, 22408163" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8752328, 9297465, 22408163; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycine betaine aldehyde dehydrogenase, NAD+-dependent" /protein_id="NP_390984.1" /db_xref="EnsemblGenomes-Gn:BSU31060" /db_xref="EnsemblGenomes-Tr:CAB15084" /db_xref="GOA:P71016" /db_xref="InterPro:IPR011264" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG11940" /db_xref="UniProtKB/Swiss-Prot:P71016" /translation="MSQTLFIDGEWISAEKEQIRSIINPFNQEEIATVSEGGREDAIK AIAAARRAFDKGEWSSLSGLERGKIVLKIAELIRRDLEELAELESLDTGKTLEESKAD MDDIANVFQYYAGLADKDGGEIISSPIPDSESKIIREPIGVCGQITPWNYPLLQASWK IAPALAAGNTIVMKPSEITPLTTIKVFKLMEEAGVPKGVANLVLGPGATVGDELAVNK DVDLISFTGGIETGKKIMRAASGNVKKIALELGGKNPNIVFKDADLEVAVDQALNAVF FHAGQVCSAGSRLLVEDAIHDQFLAELVKRAKRIKLGNGFHAETESGPLISAEHRAKV EKYVEIGIEEGAKLETGGKRPEDPELQNGFFYEPTIFSNCNSDMRIVQEEVFGPVLTV ETFSSEEEVIELANDTIYGLAGAVWSKDIEKCERVAARLRMGTVWINDFHPYFAQAPW GGYKQSGFGRELGKIGLEEYTEVKHVYRNTKPAAVNWFNS*" /label="gbsA CDS" gene complement(2809416..2810888) /gene="gbsA" /locus_tag="BSU_31060" /old_locus_tag="BSU31060" /label="gbsA gene" promotor_-10 complement(2810939..2810958) /Source="Nicolas_upshift_promotors" /id="U2408" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.8001998001998" /psig="0.999000999001" /xcortree=3079 /SigmaFactorBS="aaagaaaaatcaaaatgggaCTTTGACAgtttaaaaaccata TGTTAGATTAAGGTTGTTAAaaacattaaatttttatttaacaaactttatttacgtc a" /listShort="gbsA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2810940) /Source="Nicolas_upshifts" /id="U2408" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.8001998001998" /psig="0.999000999001" /xcortree=3079 /SigmaFactorBS="aaagaaaaatcaaaatgggaCTTTGACAgtttaaaaaccata TGTTAGATTAAGGTTGTTAAaaacattaaatttttatttaacaaactttatttacgtc a" /listShort="gbsA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2810973..2810980) /Source="Nicolas_upshift_promotors" /id="U2408" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.8001998001998" /psig="0.999000999001" /xcortree=3079 /SigmaFactorBS="aaagaaaaatcaaaatgggaCTTTGACAgtttaaaaaccata TGTTAGATTAAGGTTGTTAAaaacattaaatttttatttaacaaactttatttacgtc a" /listShort="gbsA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2811000..2811006 /Source="Nicolas_upshift_promotors" /id="U2409" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.318681318681319" /psig="0.988011988011988" /xcortree=2369 /SigmaFactorBS="tcaaagtcccattttgatttttcttTTTGACTtttcctcatg tttCGTTAAGATAAAGAACATAAagaaataacttaacgaatttaattttctaaaggaa a" /listShort="yuaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2811020..2811039 /Source="Nicolas_upshift_promotors" /id="U2409" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.318681318681319" /psig="0.988011988011988" /xcortree=2369 /SigmaFactorBS="tcaaagtcccattttgatttttcttTTTGACTtttcctcatg tttCGTTAAGATAAAGAACATAAagaaataacttaacgaatttaattttctaaaggaa a" /listShort="yuaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2811035 /Source="Nicolas_upshifts" /id="U2409" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.318681318681319" /psig="0.988011988011988" /xcortree=2369 /SigmaFactorBS="tcaaagtcccattttgatttttcttTTTGACTtttcctcatg tttCGTTAAGATAAAGAACATAAagaaataacttaacgaatttaattttctaaaggaa a" /listShort="yuaC" /GFF_Attribute="listLong" /label="upshifts" CDS 2811087..2811629 /gene="gbsR" /locus_tag="BSU_31070" /old_locus_tag="BSU31070" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8752328, 22408163" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8752328, 22408163; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor for gbsAB" /protein_id="NP_390985.1" /db_xref="EnsemblGenomes-Gn:BSU31070" /db_xref="EnsemblGenomes-Tr:CAB15085" /db_xref="GOA:P71015" /db_xref="InterPro:IPR026282" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12342" /db_xref="UniProtKB/Swiss-Prot:P71015" /translation="MDENPEFAAIEQARDLVIDSIAETMDLYGITRSVGILYGTMYMR DEMTLDEMREELQMSKPSMSTGVKKLQDLNVVKKTFHRGIRKHTFVAEKDFFKFFTNF FPPKWEREVQVNVTAIEEAQADLQKVLCKEDLDEDIKNEALQLYDQLESSKAYYDWLK RLAESVQTGEIFKFIPVETK*" /label="gbsR CDS" gene 2811087..2811629 /gene="gbsR" /locus_tag="BSU_31070" /old_locus_tag="BSU31070" /label="gbsR gene" downshifts 2811612 /Source="Nicolas_upshifts" /id="D1603" /incds=0 /nref=74 /ntot=220 /MaxReadThrough="1.70461" /MaxDrop="3.5918" /score="26.1509691" /energy="-9.9" /TU="NA" /idTUdmin="U2409" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2811706..2811713 /Source="Nicolas_upshift_promotors" /id="U2410" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.657342657342657" /psig="0.999000999001" /xcortree=3240 /SigmaFactorBS="tgtaactactacaaatttgaaaaatacgggaaaaacacccCA TTTACTtccaaaatatttgaTGGTAATTTTATGTAGGTAAaatttgtatttggccttt c" /listShort="S1185, yuaB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2811726..2811826 /Source="Nicolas_S_feature" /locus_tag="new_3187402_3187502" /HighExp="BT, S0, BI, T-1.10H, T-1.40H, T1.0H, T-0.40H, T0.0H, S2, T-2.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1185" upshifts 2811726 /Source="Nicolas_upshifts" /id="U2410" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.657342657342657" /psig="0.999000999001" /xcortree=3240 /SigmaFactorBS="tgtaactactacaaatttgaaaaatacgggaaaaacacccCA TTTACTtccaaaatatttgaTGGTAATTTTATGTAGGTAAaatttgtatttggccttt c" /listShort="S1185, yuaB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2811728..2811747 /Source="Nicolas_upshift_promotors" /id="U2410" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.657342657342657" /psig="0.999000999001" /xcortree=3240 /SigmaFactorBS="tgtaactactacaaatttgaaaaatacgggaaaaacacccCA TTTACTtccaaaatatttgaTGGTAATTTTATGTAGGTAAaatttgtatttggccttt c" /listShort="S1185, yuaB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2811827..2812372 /gene="bslA" /locus_tag="BSU_31080" /old_locus_tag="BSU31080" /function="15.3: Cell adhesion" /experiment="publication(s) with functional evidences, PMID:21097620, 21742882, 22571672, 23904481, 28698374, 28701036, 28751732" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21097620, 21742882, 22571672, 23904481, 28698374, 28701036, 28751732; Product type s: structure" /codon_start=1 /transl_table=11 /product="biofilm hydrophobic layer component" /protein_id="NP_390986.1" /db_xref="EnsemblGenomes-Gn:BSU31080" /db_xref="EnsemblGenomes-Tr:CAB15086" /db_xref="GOA:P71014" /db_xref="InterPro:IPR034650" /db_xref="PDB:4BHU" /db_xref="SubtiList:BG12341" /db_xref="UniProtKB/Swiss-Prot:P71014" /translation="MKRKLLSSLAISALSLGLLVSAPTASFAAESTSTKAHTESTMRT QSTASLFATITGASKTEWSFSDIELTYRPNTLLSLGVMEFTLPSGFTANTKDTLNGNA LRTTQILNNGKTVRVPLALDLLGAGEFKLKLNNKTLPAAGTYTFRAENKSLSIGNKFY AEASIDVAKRSTPPTQPCGCN*" /label="bslA CDS" gene 2811827..2812372 /gene="bslA" /locus_tag="BSU_31080" /old_locus_tag="BSU31080" /label="bslA gene" downshifts 2812359 /Source="Nicolas_upshifts" /id="D1604" /incds=0 /nref=109 /ntot=219 /MaxReadThrough="0.85027" /MaxDrop="6.00835" /score="20.8976757" /energy="-10.2" /TU="NA" /idTUdmin="U2410" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 2812464..2812471 /Source="Nicolas_upshift_promotors" /id="U2411" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.796203796203796" /psig="0.997002997002997" /xcortree=2704 /SigmaFactorBS="ccccgttatcttttttctggtttaaaatttaaATTGACAAac actagaaacagGAGTAAATTCTTGAGTGTTCaatttcatacagtctcttttaccgctt a" /listShort="NA, ktrA, ktrB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2812485..2812504 /Source="Nicolas_upshift_promotors" /id="U2411" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.796203796203796" /psig="0.997002997002997" /xcortree=2704 /SigmaFactorBS="ccccgttatcttttttctggtttaaaatttaaATTGACAAac actagaaacagGAGTAAATTCTTGAGTGTTCaatttcatacagtctcttttaccgctt a" /listShort="NA, ktrA, ktrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2812492 /Source="Nicolas_upshifts" /id="U2411" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.796203796203796" /psig="0.997002997002997" /xcortree=2704 /SigmaFactorBS="ccccgttatcttttttctggtttaaaatttaaATTGACAAac actagaaacagGAGTAAATTCTTGAGTGTTCaatttcatacagtctcttttaccgctt a" /listShort="NA, ktrA, ktrB" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 2812497..2812665 /gene="swdA" /locus_tag="BSU_misc_RNA_52" /product="cyclic-di-AMP-sensing riboswitch" /experiment="publication(s) with functional evidences, PMID:20511502, 23086297, 24141192, 25086507, 25086509, 26789423, 28420751" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20511502, 23086297, 24141192, 25086507, 25086509, 26789423, 28420751; Product type n: RNA" /label="swdA RNA" gene 2812497..2812665 /gene="swdA" /locus_tag="BSU_misc_RNA_52" /label="swdA gene" downshifts 2812646 /Source="Nicolas_upshifts" /id="D1605" /incds=0 /nref=16 /ntot=104 /MaxReadThrough="6.04086" /MaxDrop="4.75274" /score="3.29445061" /energy="-6.1" /TU="U2411" /idTUdmin="U2410" /TUdmin=286 /isTUend="FALSE" /label="downshifts" CDS 2812738..2813406 /gene="ktrA" /locus_tag="BSU_31090" /old_locus_tag="BSU31090" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12562800, 15096624, 23598340, 23671116, 25957408, 26771197" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562800, 15096624, 23598340, 23671116, 25957408, 26771197; Product type t : transporter" /codon_start=1 /transl_table=11 /product="potassium uptake protein" /protein_id="NP_390987.1" /db_xref="EnsemblGenomes-Gn:BSU31090" /db_xref="EnsemblGenomes-Tr:CAB15087" /db_xref="GOA:O32080" /db_xref="InterPro:IPR003148" /db_xref="InterPro:IPR006037" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR036721" /db_xref="PDB:1LSU" /db_xref="PDB:2HMS" /db_xref="PDB:2HMT" /db_xref="PDB:2HMU" /db_xref="PDB:2HMV" /db_xref="PDB:2HMW" /db_xref="PDB:4J7C" /db_xref="PDB:4J90" /db_xref="PDB:4J91" /db_xref="PDB:5BUT" /db_xref="SubtiList:BG13943" /db_xref="UniProtKB/Swiss-Prot:O32080" /translation="MGRIKNKQFAVIGLGRFGGSICKELHRMGHEVLAVDINEEKVNA YASYATHAVIANATEENELLSLGIRNFEYVIVAIGANIQASTLTTLLLKELDIPNIWV KAQNYYHHKVLEKIGADRIIHPEKDMGVKIAQSLSDENVLNYIDLSDEYSIVELLATR KLDSKSIIDLNVRAKYGCTILAIKHHGDICLSPAPEDIIREQDCLVIMGHKKDIKRFE NEGM*" /label="ktrA CDS" gene 2812738..2813406 /gene="ktrA" /locus_tag="BSU_31090" /old_locus_tag="BSU31090" /label="ktrA gene" CDS 2813413..2814750 /gene="ktrB" /locus_tag="BSU_31100" /old_locus_tag="BSU31100" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12562800, 15096624, 15849754, 16850406, 17932047, 23598340, 26771197, 28783096, 28825218" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562800, 15096624, 15849754, 16850406, 17932047, 23598340, 26771197, 28783096, 28825218; Product type t: transporter" /codon_start=1 /transl_table=11 /product="potassium transporter ATPase" /protein_id="NP_390988.1" /db_xref="EnsemblGenomes-Gn:BSU31100" /db_xref="EnsemblGenomes-Tr:CAB15088" /db_xref="GOA:O32081" /db_xref="InterPro:IPR003445" /db_xref="InterPro:IPR004772" /db_xref="PDB:4J7C" /db_xref="PDB:5BUT" /db_xref="SubtiList:BG13956" /db_xref="UniProtKB/Swiss-Prot:O32081" /translation="MTLQKDKVIKWVRFTPPQVLAIGFFLTIIIGAVLLMLPISTTKP LSWIDALFTAASATTVTGLAVVDTGTQFTVFGQTVIMGLIQIGGLGFMTFAVLIVMIL GKKIGLKERMLVQEALNQPTIGGVIGLVKVLFLFSISIELIAALILSIRLVPQYGWSS GLFASLFHAISAFNNAGFSLWPDNLMSYVGDPTVNLVITFLFITGGIGFTVLFDVMKN RRFKTFSLHTKLMLTGTLMLNAIAMLTVFILEYSNPGTLGHLHIVDKLWASYFQAVTP RTAGFNSLDFGSMREGTIVFTLLLMFIGAGSASTASGIKLTTFIVILTSVIAYLRGKK ETVIFRRSIKYPIIIKALAVSVTSLFIVFLGIFALTITEQAPFLQIVFETFSAFGTVG LTMGLTPELTTAGKCIIIVIMFIGRIGPLTFVFSFAKTEQSNIRYPDGEVFTG*" /label="ktrB CDS" gene 2813413..2814750 /gene="ktrB" /locus_tag="BSU_31100" /old_locus_tag="BSU31100" /label="ktrB gene" downshifts 2814736 /Source="Nicolas_upshifts" /id="D1606" /incds=0 /nref=9 /ntot=98 /MaxReadThrough="0.86883" /MaxDrop="3.37604" /score="25.8974852" /energy="-11.9" /TU="NA" /idTUdmin="U2411" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2814786..2815049) /gene="yubF" /locus_tag="BSU_31110" /old_locus_tag="BSU31110" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390989.1" /db_xref="EnsemblGenomes-Gn:BSU31110" /db_xref="EnsemblGenomes-Tr:CAB15089" /db_xref="GOA:O32082" /db_xref="InterPro:IPR008024" /db_xref="SubtiList:BG13955" /db_xref="UniProtKB/Swiss-Prot:O32082" /translation="MQKYRRRNTVAFTVLAYFTFFAGVFLFSIGLYNADNLELNEKGY YIAVMILVAVGAILTQKVTRDNAEDNEIIAEQEKRQNQSHIES*" /label="yubF CDS" gene complement(2814786..2815049) /gene="yubF" /locus_tag="BSU_31110" /old_locus_tag="BSU31110" /label="yubF gene" downshifts complement(2814804) /Source="Nicolas_upshifts" /id="D1607" /incds=0 /nref=237 /ntot=309 /MaxReadThrough="2.4577" /MaxDrop="7.13564" /score="30.2020977" /energy="-11.9" /TU="NA" /idTUdmin="U2412" /TUdmin="-14" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2815089..2815108) /Source="Nicolas_upshift_promotors" /id="U2412" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.543456543456543" /psig="0.994005994005994" /xcortree=2705 /SigmaFactorBS="tttactggtatttttaattctttGTTCCATTccggggaattt gAGGTATAATATTCCACGGAAgttatcactttttaactatgctttcgggagggaacaa a" /listShort="yubF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2815091) /Source="Nicolas_upshifts" /id="U2412" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.543456543456543" /psig="0.994005994005994" /xcortree=2705 /SigmaFactorBS="tttactggtatttttaattctttGTTCCATTccggggaattt gAGGTATAATATTCCACGGAAgttatcactttttaactatgctttcgggagggaacaa a" /listShort="yubF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2815121..2815128) /Source="Nicolas_upshift_promotors" /id="U2412" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.543456543456543" /psig="0.994005994005994" /xcortree=2705 /SigmaFactorBS="tttactggtatttttaattctttGTTCCATTccggggaattt gAGGTATAATATTCCACGGAAgttatcactttttaactatgctttcgggagggaacaa a" /listShort="yubF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2815158..2816006) /gene="lytG" /locus_tag="BSU_31120" /old_locus_tag="BSU31120" /EC_number="3.2.1.-" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12525152, 16855244, 28448118, 28811162" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12525152, 16855244, 28448118, 28811162; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exoglucosaminidase" /protein_id="NP_390990.1" /db_xref="EnsemblGenomes-Gn:BSU31120" /db_xref="EnsemblGenomes-Tr:CAB15090" /db_xref="GOA:O32083" /db_xref="InterPro:IPR002901" /db_xref="InterPro:IPR025987" /db_xref="SubtiList:BG13954" /db_xref="UniProtKB/Swiss-Prot:O32083" /translation="MARKKLKKRKLLISLFFLVSIPLALFVLATTLSKPIEISKETEE IDEQQVFIDSLSGHAQILYEKYHVLPSITIAQAILESDWGNSELAAKANNLFGVKGNY KGHHVTMETDEVEKGKRKTIRAKFRKYSTFFESMDDHAQLFVRGTSWNKKKYKPVLEA GNYKEAATALQTSGYATDPDYADKISAIVEKYDLDEYDEVNPSLKSVDLNASIKDSAV QDVWSKPSTDDRSIRLTSAQSYVGKDIKVVSKKQKGQSVWYQFQINDKLIGWIDDSAV EIKEAT*" /label="lytG CDS" gene complement(2815158..2816006) /gene="lytG" /locus_tag="BSU_31120" /old_locus_tag="BSU31120" /label="lytG gene" promotor_-10 complement(2816051..2816070) /Source="Nicolas_upshift_promotors" /id="U2413" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.40959040959041" /psig="0.994005994005994" /xcortree=2525 /SigmaFactorBS="gcaatcttttcccaactttatccctaaagAATTGAAAaatat tagaagtgcAAGTAAAATTCTAAAAGGTAgattcttttacattcgtaatcttttaatt c" /listShort="lytG, yubF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2816061) /Source="Nicolas_upshifts" /id="U2413" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.40959040959041" /psig="0.994005994005994" /xcortree=2525 /SigmaFactorBS="gcaatcttttcccaactttatccctaaagAATTGAAAaatat tagaagtgcAAGTAAAATTCTAAAAGGTAgattcttttacattcgtaatcttttaatt c" /listShort="lytG, yubF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2816085..2816092) /Source="Nicolas_upshift_promotors" /id="U2413" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.40959040959041" /psig="0.994005994005994" /xcortree=2525 /SigmaFactorBS="gcaatcttttcccaactttatccctaaagAATTGAAAaatat tagaagtgcAAGTAAAATTCTAAAAGGTAgattcttttacattcgtaatcttttaatt c" /listShort="lytG, yubF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2816167..2817702) /gene="yubD" /locus_tag="BSU_31130" /old_locus_tag="BSU31130" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735, 28248504; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_390991.1" /db_xref="EnsemblGenomes-Gn:BSU31130" /db_xref="EnsemblGenomes-Tr:CAB15091" /db_xref="GOA:O32084" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13953" /db_xref="UniProtKB/Swiss-Prot:O32084" /translation="MKTKHYWVISLLAVLAVGPGLMSNTALSSVQGLVQKTVGTSVFT SVNPILIGNMAFALLVPAGPLLRKKFGARPVYLASLPVFILGSLLIACSGDIALMAAG RFLQGAATGVMLMIMIPMLVLSFPIERRNYALLVLIGGFYGSVIIGTILGTIATSCGH WRWLFFIFGTLSLIGVAVSYFFLHDEHHGAADQEQPLDRAGILLSVFLAAASAVSFIF LQKWGLSSGYVWIGFGVTLCLLIGLLIVEYKVKNPFISIKLMLLPKPVLGLLIIAAGT ITVAVSLSAFQGLLRQMYDISQEHLILLSLTLLIGVAIAAILSALLYDKVGPGMLGII GGLILVFVNFQWLHIQDRSSLYMFAALFIMLAAGTGLTVAAGLMGAAMGGPLPDLVKR MTAVQFLRLFVYMGVPILIGFFTKKDAARQSGSVQDSMMTAYHDLFFISFILSVLLVC LSFCMNATGMGHKLAHKPHDKAKTAPEKPAVSAQGLSKATVKSYKVINDTEYRNALRN LQK*" /label="yubD CDS" gene complement(2816167..2817702) /gene="yubD" /locus_tag="BSU_31130" /old_locus_tag="BSU31130" /label="yubD gene" downshifts complement(2816176) /Source="Nicolas_upshifts" /id="D1608" /incds=0 /nref=45 /ntot=159 /MaxReadThrough="1.39941" /MaxDrop="4.26166" /score="-3.3162201" /energy="-5.7" /TU="NA" /idTUdmin="U2415" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_no_box 2817360..2817460 /Source="Nicolas_upshift_promotors" /id="U2414" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.407592407592408" /psig="0.127872127872128" /xcortree=1469 /SigmaFactorBS="tcagcatgacgcctgttgccgccccttgtaaaaagcgccctg ccgccatcaatgcaatatcgcctgaacatgcgatgagcagtgagcctagtataaagac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 2817420 /Source="Nicolas_upshifts" /id="U2414" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.407592407592408" /psig="0.127872127872128" /xcortree=1469 /SigmaFactorBS="tcagcatgacgcctgttgccgccccttgtaaaaagcgccctg ccgccatcaatgcaatatcgcctgaacatgcgatgagcagtgagcctagtataaagac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2817486 /Source="Nicolas_upshifts" /id="D1609" /incds=1 /nref=1 /ntot=3 /MaxReadThrough="0.0870599999999992" /MaxDrop="3.19459" /score="-1.6836786" /energy="-10.4" /TU="NA" /idTUdmin="U2416" /TUdmin="-1496" /isTUend="FALSE" /label="downshifts" S_feature complement(2817703..2817870) /Source="Nicolas_S_feature" /locus_tag="new_3193379_3193546_c" /HighExp="Cold, S8, G180, UNK1, C30, G135, S7, Lbexp, MG 25, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.34877900000000001" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1186" promotor_-10 complement(2817859..2817878) /Source="Nicolas_upshift_promotors" /id="U2415" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.642357642357642" /psig=1 /xcortree=2415 /SigmaFactorBS="agctttctatgttgtgcttgaaatttactcCATTGACAaaac acaatcgattTGAAATAATATTTGATTATAtgctcattcattcacataattataataa a" /listShort="S1186, yubD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2817870) /Source="Nicolas_upshifts" /id="U2415" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.642357642357642" /psig=1 /xcortree=2415 /SigmaFactorBS="agctttctatgttgtgcttgaaatttactcCATTGACAaaac acaatcgattTGAAATAATATTTGATTATAtgctcattcattcacataattataataa a" /listShort="S1186, yubD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2817872..2818749) /Source="Nicolas_S_feature" /locus_tag="new_3193548_3194425_c" /HighExp="G180, Cold, C30, G135, Paraq, Oxctl, S8, G150, H2O2, Heat" /AntisenseName="cdoA" /AntisenseCor="-2.3104546834536201E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1187" promotor_-35 complement(2817893..2817900) /Source="Nicolas_upshift_promotors" /id="U2415" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.642357642357642" /psig=1 /xcortree=2415 /SigmaFactorBS="agctttctatgttgtgcttgaaatttactcCATTGACAaaac acaatcgattTGAAATAATATTTGATTATAtgctcattcattcacataattataataa a" /listShort="S1186, yubD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2818112..2818121 /Source="Nicolas_upshift_promotors" /id="U2416" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1385 /SigmaFactorBS="ttttacccccacatttttttgtgttcactgggcgtttGCCGC CTCTAaattgtatatgggTAAATACCATGAATTAACCTatgaaataccaatgtaaggg a" /listShort="cdoA, S1188" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2818135..2818154 /Source="Nicolas_upshift_promotors" /id="U2416" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1385 /SigmaFactorBS="ttttacccccacatttttttgtgttcactgggcgtttGCCGC CTCTAaattgtatatgggTAAATACCATGAATTAACCTatgaaataccaatgtaaggg a" /listShort="cdoA, S1188" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2818135 /Source="Nicolas_upshifts" /id="U2416" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1385 /SigmaFactorBS="ttttacccccacatttttttgtgttcactgggcgtttGCCGC CTCTAaattgtatatgggTAAATACCATGAATTAACCTatgaaataccaatgtaaggg a" /listShort="cdoA, S1188" /GFF_Attribute="listLong" /label="upshifts" CDS 2818187..2818672 /gene="cdoA" /locus_tag="BSU_31140" /old_locus_tag="BSU31140" /EC_number="1.13.11.20" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10939241, 15699190, 16855246, 25307852, 26590284" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 15699190, 16855246, 25307852, 26590284; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cysteine dioxygenase" /protein_id="NP_390992.1" /db_xref="EnsemblGenomes-Gn:BSU31140" /db_xref="EnsemblGenomes-Tr:CAB15092" /db_xref="GOA:O32085" /db_xref="InterPro:IPR010300" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="PDB:3EQE" /db_xref="PDB:4QM8" /db_xref="PDB:4QM9" /db_xref="SubtiList:BG13952" /db_xref="UniProtKB/Swiss-Prot:O32085" /translation="MELYECIQDIFGGLKNPSVKDLATSLKQIPNAAKLSQPYIKEPD QYAYGRNAIYRNNELEIIVINIPPNKETTVHDHGQSIGCAMVLEGKLLNSIYRSTGEH AELSNSYFVHEGECLISTKGLIHKMSNPTSERMVSLHVYSPPLEDMTVFEEQKEVLEN S*" /label="cdoA CDS" gene 2818187..2818672 /gene="cdoA" /locus_tag="BSU_31140" /old_locus_tag="BSU31140" /label="cdoA gene" S_feature 2818673..2818959 /Source="Nicolas_S_feature" /locus_tag="new_3194349_3194635" /HighExp="S6, S8, S7, BT, S5, G/S, C30, Pyr, C90, Glucon" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.53171800000000002" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1188" tRNA complement(2818779..2818851) /gene="trnSL-Ala1" /locus_tag="BSU_tRNA_86" /product="tRNA-Ala" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ala (GGC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /label="trnSL-Ala1 tRNA" gene complement(2818779..2818851) /gene="trnSL-Ala1" /locus_tag="BSU_tRNA_86" /label="trnSL-Ala1 gene" downshifts complement(2818794) /Source="Nicolas_upshifts" /id="D1610" /incds=0 /nref=37 /ntot=180 /MaxReadThrough="3.88031" /MaxDrop="4.38957" /score="19.7542652" /energy="-6.2" /TU="U2417" /idTUdmin="U2419" /TUdmin=154 /isTUend="FALSE" /label="downshifts" downshifts complement(2818838) /Source="Nicolas_upshifts" /id="D1611" /incds=0 /nref=1 /ntot=11 /MaxReadThrough="5.34085" /MaxDrop="4.19639" /score="19.7542652" /energy="-6.2" /TU="U2417" /idTUdmin="U2419" /TUdmin=110 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2818862..2818881) /Source="Nicolas_upshift_promotors" /id="U2417" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=1471 /SigmaFactorBS="cttttccgagccttattttttctgtcaattcaagaggaaaca gCTTGtttttcaaaataaaATCATCTATAATAAACATGAcgttacatacggggccata g" /listShort="trnSL-Ala1, S1187, S1186, yubD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2818882) /Source="Nicolas_upshifts" /id="U2417" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=1471 /SigmaFactorBS="cttttccgagccttattttttctgtcaattcaagaggaaaca gCTTGtttttcaaaataaaATCATCTATAATAAACATGAcgttacatacggggccata g" /listShort="trnSL-Ala1, S1187, S1186, yubD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2818896..2818899) /Source="Nicolas_upshift_promotors" /id="U2417" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=1471 /SigmaFactorBS="cttttccgagccttattttttctgtcaattcaagaggaaaca gCTTGtttttcaaaataaaATCATCTATAATAAACATGAcgttacatacggggccata g" /listShort="trnSL-Ala1, S1187, S1186, yubD" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2818916 /Source="Nicolas_upshifts" /id="D1612" /incds=0 /nref=2 /ntot=13 /MaxReadThrough="3.04964" /MaxDrop="3.22361" /score="-1.6836786" /energy="-10.4" /TU="U2416" /idTUdmin="U2416" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" CDS complement(2818959..2819789) /gene="uppP" /locus_tag="BSU_31150" /old_locus_tag="BSU31150" /EC_number="3.6.1.27" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15138271, 15849754, 16850406, 27528508, 27578312" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15138271, 15849754, 16850406, 27528508, 27578312; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="undecaprenyl-pyrophosphate phosphatase" /protein_id="NP_390993.1" /db_xref="EnsemblGenomes-Gn:BSU31150" /db_xref="EnsemblGenomes-Tr:CAB15093" /db_xref="GOA:P94507" /db_xref="InterPro:IPR003824" /db_xref="SubtiList:BG13951" /db_xref="UniProtKB/Swiss-Prot:P94507" /translation="MTLWELFVAAILGIVEGLTEYAPVSSTGHMIIVDDIWLKSSNLM SEEAANSFKVVIQLGSILAVAIVFKDRILNLLGLKKNITSDQEQGHKLSIAQIAVGLV PAAVLGFLFEDYIDEYLFSVKTVAIGLIAGAILMLFADWVNKRKTATDTLDRISYKQA IAVGLFQCLSLWPGFSRSGSTISGGVILGLNHRAAADFTFIMAMPIMMGASFLSLVKH WDSLSSDLMPFFIVGFICAFVVALFVVRFFLRLINKIKLVPFAIYRIILGVILLLIMM *" /label="uppP CDS" gene complement(2818959..2819789) /gene="uppP" /locus_tag="BSU_31150" /old_locus_tag="BSU31150" /label="uppP gene" downshifts complement(2818970) /Source="Nicolas_upshifts" /id="D1613" /incds=0 /nref=60 /ntot=208 /MaxReadThrough="3.0552" /MaxDrop="5.61932" /score="-4.25033697" /energy="-6.7" /TU="U2419" /idTUdmin="U2419" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" S_feature complement(2819790..2819881) /Source="Nicolas_S_feature" /locus_tag="new_3195466_3195557_c" /HighExp="dia15, H2O2, Salt, Etha, dia5, LBGtran, M0t90, Lbstat, Mt0, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1189" CDS complement(2819882..2821048) /gene="yubA" /locus_tag="BSU_31160" /old_locus_tag="BSU31160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16385049, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_390994.1" /db_xref="EnsemblGenomes-Gn:BSU31160" /db_xref="EnsemblGenomes-Tr:CAB15094" /db_xref="GOA:O32086" /db_xref="InterPro:IPR002549" /db_xref="SubtiList:BG13950" /db_xref="UniProtKB/Swiss-Prot:O32086" /translation="METLQTWSGRFKRFFLDNKFVLFLLVLLLIGLNILVFTKTSFIF TPIIVLLKTISLPIILTGIVFYLLNPVVDFLERRRIRRIYSILLLYLLVIGLITITIV SIIPFLKEQIMSLIDNIPRYVDVVENQTKQLIGSNFVNQAQQTMNINISDLATKVSDQ AATIVNSTFTGVGNFIGALTEIIISIVTVPFILFYLLKDGRKLPVYILKFVPTRLKEQ TYTVLSEMNHRLSSYIRGQIIVSFCIGFLLFIGYLIIGLDYASLLAVIAACTSIVPYL GPTIAITPAIIIAIVTSPLMLLKLVIVWTIVQLIEGKLISPQIMGKNLHIHPITIIFL LLTAGKLFGVVGIILAIPGYAVAKVITTHLFDWFKMQSHLYDEEKNENTPGHKV*" /label="yubA CDS" gene complement(2819882..2821048) /gene="yubA" /locus_tag="BSU_31160" /old_locus_tag="BSU31160" /label="yubA gene" promotor_-35 2821044..2821048 /Source="Nicolas_upshift_promotors" /id="U2418" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.926073926073926" /psig="0.04995004995005" /xcortree=303 /SigmaFactorBS="gcttgaatctgccgctccatgtttgcaacgtcTCCACtatcg ttCCTCCGTCATACATAgtttaattaaattgtacactatcgtccctataatgaaaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2821056..2821070 /Source="Nicolas_upshift_promotors" /id="U2418" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.926073926073926" /psig="0.04995004995005" /xcortree=303 /SigmaFactorBS="gcttgaatctgccgctccatgtttgcaacgtcTCCACtatcg ttCCTCCGTCATACATAgtttaattaaattgtacactatcgtccctataatgaaaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2821072..2821091) /Source="Nicolas_upshift_promotors" /id="U2419" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=1913 /SigmaFactorBS="gttaaaaccgagaaagcttttccagcaattaacggttttTAT TTTTCattatagggacgaTAGTGTACAATTTAATTAAActatgtatgacggaggaacg a" /listShort="yubA, S1189, uppP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2821072 /Source="Nicolas_upshifts" /id="U2418" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.926073926073926" /psig="0.04995004995005" /xcortree=303 /SigmaFactorBS="gcttgaatctgccgctccatgtttgcaacgtcTCCACtatcg ttCCTCCGTCATACATAgtttaattaaattgtacactatcgtccctataatgaaaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2821091) /Source="Nicolas_upshifts" /id="U2419" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=1913 /SigmaFactorBS="gttaaaaccgagaaagcttttccagcaattaacggttttTAT TTTTCattatagggacgaTAGTGTACAATTTAATTAAActatgtatgacggaggaacg a" /listShort="yubA, S1189, uppP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2821105..2821112) /Source="Nicolas_upshift_promotors" /id="U2419" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=1913 /SigmaFactorBS="gttaaaaccgagaaagcttttccagcaattaacggttttTAT TTTTCattatagggacgaTAGTGTACAATTTAATTAAActatgtatgacggaggaacg a" /listShort="yubA, S1189, uppP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2821170..2821177 /Source="Nicolas_upshift_promotors" /id="U2420" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.79020979020979" /psig=1 /xcortree=2346 /SigmaFactorBS="attgctggaaaagctttctcggttttaacattctatttatat ctatcATGTGATTttgttcttttTAAGCTATAATTTAGCTATAtcatgcaaaaggagc g" /listShort="yulF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2821183 /Source="Nicolas_upshifts" /id="U2420" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.79020979020979" /psig=1 /xcortree=2346 /SigmaFactorBS="attgctggaaaagctttctcggttttaacattctatttatat ctatcATGTGATTttgttcttttTAAGCTATAATTTAGCTATAtcatgcaaaaggagc g" /listShort="yulF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2821188..2821207 /Source="Nicolas_upshift_promotors" /id="U2420" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.79020979020979" /psig=1 /xcortree=2346 /SigmaFactorBS="attgctggaaaagctttctcggttttaacattctatttatat ctatcATGTGATTttgttcttttTAAGCTATAATTTAGCTATAtcatgcaaaaggagc g" /listShort="yulF" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2821230..2822216 /gene="iolU" /locus_tag="BSU_31170" /old_locus_tag="BSU31170" /EC_number="1.1.1.371" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12450853, 28043209" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12450853, 28043209; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="scyllo-inositol dehydrogenase (NADP+-dependent);biofilm formation" /protein_id="NP_390995.1" /db_xref="EnsemblGenomes-Gn:BSU31170" /db_xref="EnsemblGenomes-Tr:CAB15095" /db_xref="GOA:O05265" /db_xref="InterPro:IPR000683" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12388" /db_xref="UniProtKB/Swiss-Prot:O05265" /translation="MIRFAIIGTNWITDRFLESAADIEDFQLTAVYSRSAERAGEFAA KHNAAHAFSDLQEMAASDCFDAVYIASPNALHKEQAVLFMNHGKHVLCEKPFASNTKE TEEMISAAKANGVVLMEAMKTTFLPNFKELKKHLHKIGTVRRFTASYCQYSSRYDAFR SGTVLNAFQPELSNGSLMDIGVYCIYPAVVLFGAPKDVKANGYALSSGVDGEGTVILS YDGFEAVLMHSKISTSYAPAEIQGEDGTIVIDTIHRPERVEIRYRDGRLENIAIPDPK PAMFYEAEEFVTLIKENKLESEENTFERSLTTAKIMEEARKQMGIVYPADQA*" /label="iolU CDS" gene 2821230..2822216 /gene="iolU" /locus_tag="BSU_31170" /old_locus_tag="BSU31170" /label="iolU gene" downshifts 2822187 /Source="Nicolas_upshifts" /id="D1614" /incds=0 /nref=30 /ntot=279 /MaxReadThrough="1.83109" /MaxDrop="4.96985" /score="21.8997198" /energy="-15.1" /TU="NA" /idTUdmin="U2420" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(2822257..2823531) /gene="rhaA" /locus_tag="BSU_31180" /old_locus_tag="BSU31180" /EC_number="5.3.1.14" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10960106, 26712933" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10960106, 26712933; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-rhamnose isomerase" /protein_id="NP_390996.1" /db_xref="EnsemblGenomes-Gn:BSU31180" /db_xref="EnsemblGenomes-Tr:CAB15096" /db_xref="GOA:O05264" /db_xref="InterPro:IPR009308" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG12387" /db_xref="UniProtKB/Swiss-Prot:O05264" /translation="MTIKANYDSAKQAYEKWGIDVEEALRQLEQVPISIHCWQGDDIE GFEVNKGELSGGIDVTGNYPGKAQTPEELRRDLEKALSLIPGKHRVNLHAIYAETNRE AVERDELKPQHFENWVKWAKNLGLGLDFNPTLFSHEKAADGLTLSHPDPDIREFWIRH CIACRRIGEYFGKELGTPCLTNIWIPDGYKDIPSDRLTPRKRLKESLDRIFSEEISEQ HNLDSIESKLFGLGSESYVVGSHEFYLAYALTNHKLCLLDTGHFHPTETVSNKISSML LYTDKLALHVSRPVRWDSDHVVVLDDELREIALEIVRNHALEKVAIGLDFFDASINRV AAWTIGTRNMIKALLYALLLPNGYLKQLQEEGRYTERLALMEEFKTYPFGAIWDSYCE QMGVPVKEAWLYDIKEYEQQVLLKRKASSPIV*" /label="rhaA CDS" gene complement(2822257..2823531) /gene="rhaA" /locus_tag="BSU_31180" /old_locus_tag="BSU31180" /label="rhaA gene" downshifts complement(2822270) /Source="Nicolas_upshifts" /id="D1615" /incds=0 /nref=3 /ntot=29 /MaxReadThrough="0.802" /MaxDrop="4.45322" /score="14.0829844" /energy="-12.6" /TU="NA" /idTUdmin="U2421" /TUdmin=242 /isTUend="FALSE" /label="downshifts" CDS complement(2823557..2823871) /gene="rhaM" /locus_tag="BSU_31190" /old_locus_tag="BSU31190" /EC_number="5.1.3.32" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15576793, 15876375, 26712933" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15576793, 15876375, 26712933; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-rhamnose mutarotase" /protein_id="NP_390997.1" /db_xref="EnsemblGenomes-Gn:BSU31190" /db_xref="EnsemblGenomes-Tr:CAB15097" /db_xref="GOA:O05263" /db_xref="InterPro:IPR008000" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR013448" /db_xref="SubtiList:BG12386" /db_xref="UniProtKB/Swiss-Prot:O05263" /translation="MKRKASIMFVHQDKYEEYKQRHDDIWPEMAEALKAHGAHHYSIF LDEETGRLFAYLEIEDEEKWRKMADTEVCQRWWKSMAPLMKTNSDFSPVAIDLKEVFY LD*" /label="rhaM CDS" gene complement(2823557..2823871) /gene="rhaM" /locus_tag="BSU_31190" /old_locus_tag="BSU31190" /label="rhaM gene" CDS complement(2823889..2825346) /gene="rhaB" /locus_tag="BSU_31200" /old_locus_tag="BSU31200" /EC_number="2.7.1.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16674975, 26712933" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16674975, 26712933; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="rhamnulokinase" /protein_id="NP_390998.1" /db_xref="EnsemblGenomes-Gn:BSU31200" /db_xref="EnsemblGenomes-Tr:CAB15098" /db_xref="GOA:O05262" /db_xref="InterPro:IPR000577" /db_xref="InterPro:IPR013449" /db_xref="InterPro:IPR018484" /db_xref="InterPro:IPR018485" /db_xref="SubtiList:BG12385" /db_xref="UniProtKB/Swiss-Prot:O05262" /translation="MIYTAIDVGASSGRIMVGELNEGKLDIQEIHRFANGFSQRDGHC LWDIDHLLKQILQGLQKVKTLGYEHCTVGIDTWAVDYVLLDEKGDRLREAISYRDRRT DHTIDKLEHTLSKAAIYQKTGIQFQPFNTIYQLFEEDRELLKKTDKIMMIPDYLGYCL TGKAVTEITNVSTTQLLNVSTGNLDPELLEAVSVLEQQFAPLTEPGCELGKLRNEWFP DYDLPACKVMTVATHDTASAVIAAPGVNDGWAYISSGTWSLIGVENKTPIITDLALEN NYTNERGANNTIRFLKNIIGMWVIQEVKQQLQADYSFQQLAEEAKKTEPFQQFINLND KRFLNPENMIKEIQHYCRQTRQKIPRTAGELACCIYSNLAIIYAIAIKELETITEKPI EQFHIIGGGARNDFLNQLTADMSGKAVYAGPIEATATGNLLMQMIAAKEVKDIKEARQ VVRNSFPIKVFTPKDIDRSTIIQSFQQTVLKALSK*" /label="rhaB CDS" gene complement(2823889..2825346) /gene="rhaB" /locus_tag="BSU_31200" /old_locus_tag="BSU31200" /label="rhaB gene" CDS complement(2825351..2826127) /gene="rhaR" /locus_tag="BSU_31210" /old_locus_tag="BSU31210" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11496004, 26712933" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11496004, 26712933; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of the rhamnose operon(RhaR / l-rhamnulose-1-phosphate)" /protein_id="NP_390999.1" /db_xref="EnsemblGenomes-Gn:BSU31210" /db_xref="EnsemblGenomes-Tr:CAB15099" /db_xref="GOA:O05261" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR014036" /db_xref="InterPro:IPR018356" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12384" /db_xref="UniProtKB/Swiss-Prot:O05261" /translation="MLVAERQQKIVEIVNMRSSIRVSELSDIFSVTEETIRRDLEKLE KEHKLSRSHGGAVSIQQKESEIHFSEREITNVIEKKAIAHEAAKYVKSGDRIILDAST TAWYMAKILPDIELTVITNSMKAAIELSNKENISVISTGGILLEKSLSFAGPLAERSL ETYHVNKTFLSCKGFDVHNGMSDSNEWQALLKKRMIERSDQTILMADSSKWGNREFSH IASLQDVSRLITDSGLDPASVKALEDKKVKVTAVPLSKRG*" /label="rhaR CDS" gene complement(2825351..2826127) /gene="rhaR" /locus_tag="BSU_31210" /old_locus_tag="BSU31210" /label="rhaR gene" misc_feature complement(2826161..2826180) /Source="Nicolas_upshift_promotors" /id="U2421" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig="0.999000999001" /xcortree=3189 /SigmaFactorBS="acgggctgcatgatcacggtagacggcggcgtccctgctgct tttacgcgttagataTATGCTATGATAAAAATATAagacggactacgatatgaggaag g" /listShort="yulB, yulC, yulD, yulE" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2826177) /Source="Nicolas_upshifts" /id="U2421" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig="0.999000999001" /xcortree=3189 /SigmaFactorBS="acgggctgcatgatcacggtagacggcggcgtccctgctgct tttacgcgttagataTATGCTATGATAAAAATATAagacggactacgatatgaggaag g" /listShort="yulB, yulC, yulD, yulE" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2826184..2828253) /gene="rhaE" /locus_tag="BSU_31220" /old_locus_tag="BSU31220" /EC_number="1.1.1.-" /EC_number="4.1.2.19" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:24391637, 26712933" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 24391637, 26712933; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional rhamnulose-1-phosphate aldolase/alcohol dehydrogenase" /protein_id="NP_391000.1" /db_xref="EnsemblGenomes-Gn:BSU31220" /db_xref="EnsemblGenomes-Tr:CAB15100" /db_xref="GOA:P40747" /db_xref="InterPro:IPR001303" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR013454" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR036409" /db_xref="SubtiList:BG10947" /db_xref="UniProtKB/Swiss-Prot:P40747" /translation="MVKHIWDSERAAQLPKGVEELVYRSNLIGSDRTVCNWGGGNTSM KTTEKDFRGREIEVMWVKGSGSDLATMKAHNFSGLKLDDIRPLIKRDQMPDEEMVDYL SHCMIDSKHPRPSIETLLHAFLPYKHVDHTHPDAIISICCADNGKQIAEDIYGNRFVW VPYVRPGFTLSKMIAEGVANNPHAELVLMEKHGLVTWGETSETCYQKTISIIQEAEQY INDRINQHEVFGGKRYQPLPEDKRKQILAGIMPVIRGAVSEEKKMILSYDDHDDVLEF VNSVQAPALSQIGAACPDHLVHTKRVPLYIDWNPETQDVHKLADLIKSGVETFTSEYQ AYFTRNQQDGDQIFESAPRVILIPGIGMVNTGKSYAMSKVSGALYRRAIAVMKGATAL GQFVSLHENESYHVEYWPLELYKLTLAPPEAEFSRKVALITGGAGGIGSAACRRFAAE GGHVIVADLNIEGAQKIAGEINDAYGKGRAMAVKMDVTKEEDVQSAFERAALAYGGID IVVNNAGLATSSPFDETSLKEWNLNMNVLGTGYFLVAREAFKQMKHQNRGGSMVFVGS KNSVYAGKNASAYSSVKALETHLARCIAAEGGEFGIRVNSVLPDAVLQGSAIWGSSWR EERAAAYGIEPDQLEEHYRKRTALLVNIYPEDIAEAIAFFASSKAEKTTGCMITVDGG VPAAFTR*" /label="rhaE CDS" gene complement(2826184..2828253) /gene="rhaE" /locus_tag="BSU_31220" /old_locus_tag="BSU31220" /label="rhaE gene" promotor_-10 complement(2828286..2828305) /Source="Nicolas_upshift_promotors" /id="U2422" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.472527472527473" /psig=1 /xcortree=1572 /SigmaFactorBS="tttttttgttaaaaagcaaaaataaacaaaaacGATTCAAaa acaaacagaaaTCATATATAATGAAAACGGAtacaaataaaagggtatggaggaatat c" /listShort="yuxG, yulB, yulC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2828298) /Source="Nicolas_upshifts" /id="U2422" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.472527472527473" /psig=1 /xcortree=1572 /SigmaFactorBS="tttttttgttaaaaagcaaaaataaacaaaaacGATTCAAaa acaaacagaaaTCATATATAATGAAAACGGAtacaaataaaagggtatggaggaatat c" /listShort="yuxG, yulB, yulC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2828319..2828325) /Source="Nicolas_upshift_promotors" /id="U2422" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.472527472527473" /psig=1 /xcortree=1572 /SigmaFactorBS="tttttttgttaaaaagcaaaaataaacaaaaacGATTCAAaa acaaacagaaaTCATATATAATGAAAACGGAtacaaataaaagggtatggaggaatat c" /listShort="yuxG, yulB, yulC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2828391..2830379) /gene="tlpB" /locus_tag="BSU_31230" /old_locus_tag="BSU31230" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:8188684, 10825179, 14563871" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8188684, 10825179, 14563871; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="methyl-accepting chemotaxis protein" /protein_id="NP_391001.1" /db_xref="EnsemblGenomes-Gn:BSU31230" /db_xref="EnsemblGenomes-Tr:CAB15101" /db_xref="GOA:P39217" /db_xref="InterPro:IPR003122" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033479" /db_xref="SubtiList:BG10862" /db_xref="UniProtKB/Swiss-Prot:P39217" /translation="MGKFIQWIKQPSISKPLIAAFLAVLILPVGVLAYFSYQSAWNAL DRELISSAKGNVEELNSTLQNKLEDKVKAIDYYSETVDKDILLGKNKTLLKEKFKQYT TLNDDVGAIYAASEDKKLYKYPDSGVPKGFDPTGRDWYKQAVAEKGQAVFSEPYTDEA TGDIVVTISKQLKDGSGVIALDLNLDEVLTASKRIKIGKEGFAFITTGNKKYIAHPTI KPGTTGSGDWTNQVYSKKEGSFEYTFEGKEKKMAFTTNKLTGWKIAGTYFVSELQDAS SPVLNTAVIILCVSIVIGGILILYIIRAITKPLRKLVSTSAKISSGDLTEVIDIHSKN EFGQLGESFNEMSASLRSVIGVIQTSVENVASSSEELTASAAQTSKATEHITLAIEQF SDGNEAQSEKLETSSNHLSQMNEGISKVAQASSTITKSSIQSSEAAGSGEKLVEHTVG QMKTIDQSVQKAEAVVKGLETKSQDITSILNVINGIADQTNLLALNAAIEAARAGEYG RGFSVVAEEVRKLAVQSADSAKEIEGLIQEIVREISTSLSMFQSVNHEVKEGLQITDQ TAESFKQIYEMTTQISGELQNLNATVEQLSAGSQEVSSAVEDISAVAKESSAGIQDIA ASAEEQLASMEEISSSAETLANMAEELQDITKKFKIES*" /label="tlpB CDS" gene complement(2828391..2830379) /gene="tlpB" /locus_tag="BSU_31230" /old_locus_tag="BSU31230" /label="tlpB gene" downshifts complement(2828410) /Source="Nicolas_upshifts" /id="D1616" /incds=0 /nref=108 /ntot=174 /MaxReadThrough="3.32915" /MaxDrop="6.75141" /score="18.7221191" /energy="-8.3" /TU="NA" /idTUdmin="U2423" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 2830383..2830390 /Source="Nicolas_upshift_promotors" /id="U2424" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.426573426573427" /psig="0.735264735264735" /xcortree=662 /SigmaFactorBS="ttgtatgaattttcccattctCGTTGACTcctcctttaagat aaATCTAATATCGTCAAACTAGgataaaaggtttaataaaaaaactaaaaaaaacacc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2830400..2830418) /Source="Nicolas_upshift_promotors" /id="U2423" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2793 /SigmaFactorBS="ttgttgcgcttgggtgttttttttagtttttttaTTAAACCT tttatcctagtttGACGATATTAGATTTATCTtaaaggaggagtcaacgagaatggga a" /listShort="tlpB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2830406..2830425 /Source="Nicolas_upshift_promotors" /id="U2424" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.426573426573427" /psig="0.735264735264735" /xcortree=662 /SigmaFactorBS="ttgtatgaattttcccattctCGTTGACTcctcctttaagat aaATCTAATATCGTCAAACTAGgataaaaggtttaataaaaaaactaaaaaaaacacc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2830413) /Source="Nicolas_upshifts" /id="U2423" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2793 /SigmaFactorBS="ttgttgcgcttgggtgttttttttagtttttttaTTAAACCT tttatcctagtttGACGATATTAGATTTATCTtaaaggaggagtcaacgagaatggga a" /listShort="tlpB" /GFF_Attribute="listLong" /label="upshifts" upshifts 2830422 /Source="Nicolas_upshifts" /id="U2424" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.426573426573427" /psig="0.735264735264735" /xcortree=662 /SigmaFactorBS="ttgtatgaattttcccattctCGTTGACTcctcctttaagat aaATCTAATATCGTCAAACTAGgataaaaggtttaataaaaaaactaaaaaaaacacc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2830432..2830439) /Source="Nicolas_upshift_promotors" /id="U2423" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2793 /SigmaFactorBS="ttgttgcgcttgggtgttttttttagtttttttaTTAAACCT tttatcctagtttGACGATATTAGATTTATCTtaaaggaggagtcaacgagaatggga a" /listShort="tlpB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2830488 /Source="Nicolas_upshifts" /id="D1617" /incds=0 /nref=4 /ntot=11 /MaxReadThrough="1.04089" /MaxDrop="4.2056" /score="13.4355481" /energy="-10.7" /TU="NA" /idTUdmin="U2424" /TUdmin=22 /isTUend="TRUE" /label="downshifts" CDS complement(2830493..2832478) /gene="mcpA" /locus_tag="BSU_31240" /old_locus_tag="BSU31240" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:8188684, 9721285, 12011078" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8188684, 9721285, 12011078; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="methyl-accepting chemotaxis protein" /protein_id="NP_391002.2" /db_xref="EnsemblGenomes-Gn:BSU31240" /db_xref="EnsemblGenomes-Tr:CAB15102" /db_xref="GOA:P39214" /db_xref="InterPro:IPR003122" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033479" /db_xref="SubtiList:BG10861" /db_xref="UniProtKB/Swiss-Prot:P39214" /translation="MKKILQLIKQRSITRKLLVSFLSILIIPVVILAIFAYQSASSSL DRQMMGSALENVQQLNEIINTSIGEKENSADYFSEWLTKEKYNAKSNASIAEKFSQYI SINKDVESIYTSDTKGHFTRYPDLPMPSGYNPVERDWYKKAVANKGKVVITDPYKTAS TNTMVVTIAQQTKDGSGVIAINMTIENLLKTTKKVNIGTQGYAFIMTKDKKVVAHPNE QSGTELKGDWLDKMLSADKGDFQYTMDGDKKKMAFDTNKLTGWKIGGTMYLDEIHEAA QPVLHLALIVLAAAIIIGIIVMTLIIRSITTPLKQLVGSSKRISEGDLTETIDIRSKD ELGELGKSFNNMASSLRSLIHAIQDSVDNVAASSEELTASAAQTSKATEHITLAIEQF SNGNEKQNENIETAAEHIYQMNDGLTNMAQASEVITDSSVQSTEIASEGGKLVHQTVG QMNVIDKSVKEAEQVVRGLETKSKDITNILRVINGIADQTNLLALNAAIEAARAGEYG RGFSVVAEEVRKLAVQSADSAKEIEGLIIEIVKEINTSLGMFQSVNQEVQTGLDITDK TEMSFKRISEMTNQIAGELQNMSATVQQLSASSEEVSGASEHIASISKESSAHIQDIA ASAEEQLASMEEISSSAETLSSMAEELRDMTKRFKIE*" /label="mcpA CDS" gene complement(2830493..2832478) /gene="mcpA" /locus_tag="BSU_31240" /old_locus_tag="BSU31240" /label="mcpA gene" downshifts complement(2830498) /Source="Nicolas_upshifts" /id="D1618" /incds=0 /nref=196 /ntot=232 /MaxReadThrough="3.11319" /MaxDrop="7.54297" /score="40.6270404" /energy="-13.6" /TU="U2425" /idTUdmin="U2425" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2832499..2832517) /Source="Nicolas_upshift_promotors" /id="U2425" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2798 /SigmaFactorBS="aattagttacttttgttaaatttcttcttttttgctGTATAT ATttacccatttccaGCCGATATGAAGGGTAGCAtaaaaaaggagaaatgaatgatga a" /listShort="mcpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2832514) /Source="Nicolas_upshifts" /id="U2425" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2798 /SigmaFactorBS="aattagttacttttgttaaatttcttcttttttgctGTATAT ATttacccatttccaGCCGATATGAAGGGTAGCAtaaaaaaggagaaatgaatgatga a" /listShort="mcpA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2832516..2832603) /Source="Nicolas_S_feature" /locus_tag="new_3208192_3208279_c" /HighExp="GM 150, T0.0H, T-1.40H, T-0.40H, MG 150, T-5.40H, T-3.40H, T-1.10H, T-2.40H, M/G" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1190" promotor_-35 complement(2832531..2832538) /Source="Nicolas_upshift_promotors" /id="U2425" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2798 /SigmaFactorBS="aattagttacttttgttaaatttcttcttttttgctGTATAT ATttacccatttccaGCCGATATGAAGGGTAGCAtaaaaaaggagaaatgaatgatga a" /listShort="mcpA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2832604..2834592) /gene="tlpA" /locus_tag="BSU_31250" /old_locus_tag="BSU31250" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:8188684, 10825179, 14563871, 26522943" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8188684, 10825179, 14563871, 26522943; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="methyl-accepting chemotaxis protein (membrane curvature dependent localisation)" /protein_id="NP_391003.1" /db_xref="EnsemblGenomes-Gn:BSU31250" /db_xref="EnsemblGenomes-Tr:CAB15103" /db_xref="GOA:P39216" /db_xref="InterPro:IPR003122" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033479" /db_xref="SubtiList:BG10860" /db_xref="UniProtKB/Swiss-Prot:P39216" /translation="MKKTLTTIRRSSIARRLIISFLLILIVPITALSVSAYQSAVASL DVQMTQSAKENVQILDHIIDDKISTTEKSLAYFSDWATAEKFQDKKKTELKQEFKQFI QMNDNVAAVFSSGKDGDFTRYPYADMPSDFNALERDWYKEAMANKGKTIVTEPYESIS SGKMVVTIARQTVDGSGVVAIDMKIDDLVTTAKGINIGKEGYAFILSQNKKVIAYSGE KAGTELKGDWVDKLYKDKSGDFEYTYKGKKKKMAFATSQTTGWKISGTMYANEIHDAA SRVLIMASIVLAIAIGAGMTAIYFVIRSITKPLRRIVASAEKISEGDLTETIEINSKD ELGVLSESFNHMAHSLRSLIHGIKDSVEHVASSSEELTASADQTSRATEHITMAIEQF SNGSESQSEKIETTTEQINEMNDGLAELARAAAVITETSADSTEVSSKGETLVQKTAG QMNTIDHSVKAAEQVVKGLEIKSKDITNILRVINGIADQTNLLALNAAIEAARAGEYG RGFSVVAEEVRKLAVQSADSAKEIESLISEIVKEIHTSLNVLQSVNKEVETGLVMTDE TKQSFKHISQMTNQIASELQNMNATVEELSAGAQEISAASNDITAISKESSDGIQDIA ASAEEQLASMEEISSSALTLERMSEELRDLTKQFKVDK*" /label="tlpA CDS" gene complement(2832604..2834592) /gene="tlpA" /locus_tag="BSU_31250" /old_locus_tag="BSU31250" /label="tlpA gene" promotor_-10 complement(2834617..2834635) /Source="Nicolas_upshift_promotors" /id="U2426" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2835 /SigmaFactorBS="atttagaactatttttcattttttcctccattttcaATGTAA TTtaaaggaagatccGCCGATATAATTTGTAAATtattgaaagaaggttcaaaaggaa a" /listShort="tlpA, S1190" /listLong="mcpA" /label="promotor_-10" upshifts complement(2834632) /Source="Nicolas_upshifts" /id="U2426" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2835 /SigmaFactorBS="atttagaactatttttcattttttcctccattttcaATGTAA TTtaaaggaagatccGCCGATATAATTTGTAAATtattgaaagaaggttcaaaaggaa a" /listShort="tlpA, S1190" /listLong="mcpA" /label="upshifts" promotor_-35 complement(2834649..2834656) /Source="Nicolas_upshift_promotors" /id="U2426" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2835 /SigmaFactorBS="atttagaactatttttcattttttcctccattttcaATGTAA TTtaaaggaagatccGCCGATATAATTTGTAAATtattgaaagaaggttcaaaaggaa a" /listShort="tlpA, S1190" /listLong="mcpA" /label="promotor_-35" CDS complement(2834769..2836757) /gene="mcpB" /locus_tag="BSU_31260" /old_locus_tag="BSU31260" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:12011078, 14731274, 15317802, 15544802, 19901023, 20864474, 22931217, 27899502" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12011078, 14731274, 15317802, 15544802, 19901023, 20864474, 22931217, 27899502; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="methyl-accepting chemotaxis protein" /protein_id="NP_391004.2" /db_xref="EnsemblGenomes-Gn:BSU31260" /db_xref="EnsemblGenomes-Tr:CAB15104" /db_xref="GOA:P39215" /db_xref="InterPro:IPR003122" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033479" /db_xref="SubtiList:BG10859" /db_xref="UniProtKB/Swiss-Prot:P39215" /translation="MKTFINWLKKPSISKKLIVSFIAILIIPILILEFSSYRSASGKL DQEIMGNAKNSVDTFNTTVTNDLGEKAKAVTFFSESLKRSAFKGKSNQEEIKAKFSQY VSINQGVARIYGGADNGTYVQAPKEKLPEGYDPRQRPWYQDAMKAGGEIVVTDPYVAA SDGSMVITIAQELKDGSGVVAMDITIDKLLEQMKQIKVGKEGYAFIATKNKTYVAHKN HKAGEKLSGDWVAKMYANDSGELQYTLNNEDKKMTYTTNELTGWKIAGTMYMDEIKDA SKSVLTTGMIVLIASIVAGGILILFIVRSITKPLKRLVQSSKTISRGDLTETIEIHSK DELGELGESFNEMGQSLRSLISAIQDSVNNVAASSEQLTASAGQTSKATEHITMAIEQ FSNGNEEQSEKVESSSHQLNLMNEGLQQVSQTSSDITKASIQSTEIAGTGEKFVQQTV GQMNSINQSVQQAEAVVKGLEGKSKDITSILRVINGIADQTNLLALNAAIEAARAGES GRGFSVVAEEVRKLAVQSADSAKEIEKLIQEIVAEIDTSLHMFKEVNQEVQSGLVVTD NTKESFQSIFSMTNEIAGKLQTMNSTVEQLSDRSQHVSAAVSGIADVSKESSASIQDI AASAEEQLASMEEISSSATTLAQMAEELRDLTKQFKIE*" /label="mcpB CDS" gene complement(2834769..2836757) /gene="mcpB" /locus_tag="BSU_31260" /old_locus_tag="BSU31260" /label="mcpB gene" downshifts complement(2834788) /Source="Nicolas_upshifts" /id="D1619" /incds=0 /nref=136 /ntot=224 /MaxReadThrough="3.76161" /MaxDrop="7.09773" /score="30.8363643" /energy="-10.7" /TU="U2427" /idTUdmin="U2427" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2836778..2836796) /Source="Nicolas_upshift_promotors" /id="U2427" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2799 /SigmaFactorBS="aaaaaggcagaagacagccaaaaagaacttcttccatttttt aTTTTAAAActtttttaagcaGCCGATATATACTGTATCAaacctgaaggagcaagtg a" /listShort="mcpB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2836799) /Source="Nicolas_upshifts" /id="U2427" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2799 /SigmaFactorBS="aaaaaggcagaagacagccaaaaagaacttcttccatttttt aTTTTAAAActtttttaagcaGCCGATATATACTGTATCAaacctgaaggagcaagtg a" /listShort="mcpB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2836809..2836816) /Source="Nicolas_upshift_promotors" /id="U2427" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2799 /SigmaFactorBS="aaaaaggcagaagacagccaaaaagaacttcttccatttttt aTTTTAAAActtttttaagcaGCCGATATATACTGTATCAaacctgaaggagcaagtg a" /listShort="mcpB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2836859..2836868 /Source="Nicolas_upshift_promotors" /id="U2428" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1304 /SigmaFactorBS="ggaagaagttctttttggctgtcttctgccttttTAACTTTC ATtgcccaagctcttTGCATATCTTATAAAAAACAaggggggctaaacatgattattg t" /listShort="tgl, S1191" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2836882..2836901 /Source="Nicolas_upshift_promotors" /id="U2428" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1304 /SigmaFactorBS="ggaagaagttctttttggctgtcttctgccttttTAACTTTC ATtgcccaagctcttTGCATATCTTATAAAAAACAaggggggctaaacatgattattg t" /listShort="tgl, S1191" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2836885 /Source="Nicolas_upshifts" /id="U2428" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1304 /SigmaFactorBS="ggaagaagttctttttggctgtcttctgccttttTAACTTTC ATtgcccaagctcttTGCATATCTTATAAAAAACAaggggggctaaacatgattattg t" /listShort="tgl, S1191" /GFF_Attribute="listLong" /label="upshifts" CDS 2836915..2837652 /gene="tgl" /locus_tag="BSU_31270" /old_locus_tag="BSU31270" /EC_number="2.3.2.13" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9692191, 16267299, 16751597, 16936016, 18249137, 26322858" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9692191, 16267299, 16751597, 16936016, 18249137, 26322858; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="protein-glutamine gamma-glutamyltransferase (transglutaminase)" /protein_id="NP_391005.1" /db_xref="EnsemblGenomes-Gn:BSU31270" /db_xref="EnsemblGenomes-Tr:CAB15105" /db_xref="GOA:P40746" /db_xref="InterPro:IPR020916" /db_xref="PDB:4P8I" /db_xref="PDB:4PA5" /db_xref="SubtiList:BG10946" /db_xref="UniProtKB/Swiss-Prot:P40746" /translation="MIIVSGQLLRPQDIENWQIDQDLNPLLKEMIETPVQFDYHSIAE LMFELKLRMNIVAAAKTLHKSGAKFATFLKTYGNTTYWRVSPEGALELKYRMPPSKAI RDIAENGPFYAFECATAIVIIYYLALIDTIGEDKFNASFDRIILYDWHYEKLPIYTET GHHFFLGDCLYFKNPEFDPQKAQWRGENVILLGEDKYFAHGLGILNGKQIIDKLNSFR KKGALQSAYLLSQATRLDVPSLFRIVR*" /label="tgl CDS" gene 2836915..2837652 /gene="tgl" /locus_tag="BSU_31270" /old_locus_tag="BSU31270" /label="tgl gene" promotor_-10 complement(2836940..2836959) /Source="Nicolas_upshift_promotors" /id="U2429" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.694305694305694" /psig=1 /xcortree=1815 /SigmaFactorBS="caatcatctcttttaagagcggattcagaTCTTGatcaatct gccaattTTCAATATCCTGGGGACGGAgcaattgtcctgatacaataatcatgtttag c" /GFF_Attribute="listShort" /listLong="mcpB" /label="promotor_-10" upshifts complement(2836948) /Source="Nicolas_upshifts" /id="U2429" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.694305694305694" /psig=1 /xcortree=1815 /SigmaFactorBS="caatcatctcttttaagagcggattcagaTCTTGatcaatct gccaattTTCAATATCCTGGGGACGGAgcaattgtcctgatacaataatcatgtttag c" /GFF_Attribute="listShort" /listLong="mcpB" /label="upshifts" promotor_-35 complement(2836975..2836979) /Source="Nicolas_upshift_promotors" /id="U2429" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.694305694305694" /psig=1 /xcortree=1815 /SigmaFactorBS="caatcatctcttttaagagcggattcagaTCTTGatcaatct gccaattTTCAATATCCTGGGGACGGAgcaattgtcctgatacaataatcatgtttag c" /GFF_Attribute="listShort" /listLong="mcpB" /label="promotor_-35" S_feature 2837653..2840473 /Source="Nicolas_S_feature" /locus_tag="new_3213329_3216149" /HighExp="S6, S8, S7, BT, S5, C30, B36, Pyr, BC, C90" /AntisenseName="yugT" /AntisenseCor="0.63350809138227804" /AntisenseRegPval="-30.9" /CDS_PredictionProba="0.61985900000000005" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1191" CDS complement(2837666..2837920) /gene="yuzH" /locus_tag="BSU_31279" /old_locus_tag="BSU31279" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097776.1" /db_xref="EnsemblGenomes-Gn:BSU31279" /db_xref="EnsemblGenomes-Tr:CAX52682" /db_xref="UniProtKB/Swiss-Prot:C0H3Q3" /translation="MNILQYSYKKRGKIEFVFEGWPHSKVTMVPIKGYYFVRFIKWSS QDPIVTRNDLEKMEWAANQYFGTAPFYRKRKAFETPSSGK*" /label="yuzH CDS" gene complement(2837666..2837920) /gene="yuzH" /locus_tag="BSU_31279" /old_locus_tag="BSU31279" /label="yuzH gene" downshifts complement(2837692) /Source="Nicolas_upshifts" /id="D1620" /incds=0 /nref=1 /ntot=13 /MaxReadThrough="2.39206" /MaxDrop="2.92958" /score="-2.51333596" /energy="-14.7" /TU="NA" /idTUdmin="U2430" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2837921..2838177) /Source="Nicolas_S_feature" /locus_tag="new_3213597_3213853_c" /HighExp="Etha, Sw, Salt, Gly, BC, M9-stat, Lbstat, Heat, LPhT, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.37980700000000001" /TUshortSig="SigB" /TUshortPSig="0.969" /TUlongSig="NA" /TUlongPSig="NA" /label="S1192" CDS complement(2838178..2838576) /gene="yugU" /locus_tag="BSU_31280" /old_locus_tag="BSU31280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391006.2" /db_xref="EnsemblGenomes-Gn:BSU31280" /db_xref="EnsemblGenomes-Tr:CAB15106" /db_xref="InterPro:IPR001602" /db_xref="InterPro:IPR035917" /db_xref="SubtiList:BG12373" /db_xref="UniProtKB/Swiss-Prot:O05243" /translation="MLKTLQIKTTKRDEMIDITREVEAFLQETGITSGAALIYCPHTT AGITINENADPDVKKDMLRRFDEVYPWEHELDRHMEGNTAAHMKSSTVGASQHVIVEN GRLILGTWQGIYFCEFDGPRTRTCYIKMMG*" /label="yugU CDS" gene complement(2838178..2838576) /gene="yugU" /locus_tag="BSU_31280" /old_locus_tag="BSU31280" /label="yugU gene" CDS complement(2838536..2838670) /locus_tag="BSU_31289" /old_locus_tag="BSU31289" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514000.1" /translation="MFYRVYESGLTGKKRTQNELSDESGQTKGETNAENTANQNNQTR *" /label="hypothetical protein CDS" gene complement(2838536..2838670) /locus_tag="BSU_31289" /old_locus_tag="BSU31289" /label="gene" promotor_-10 complement(2838619..2838638) /Source="Nicolas_upshift_promotors" /id="U2430" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=145 /SigmaFactorBS="ttagactggagtttttttgttttatcgGGTTTATgagagcgg tttaacAGGAAAAAAAAGAACACAGAacgaattaagcgatgagagcggacaaacgaaa g" /listShort="yugU, S1192, yuzH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2838626) /Source="Nicolas_upshifts" /id="U2430" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=145 /SigmaFactorBS="ttagactggagtttttttgttttatcgGGTTTATgagagcgg tttaacAGGAAAAAAAAGAACACAGAacgaattaagcgatgagagcggacaaacgaaa g" /listShort="yugU, S1192, yuzH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2838653..2838659) /Source="Nicolas_upshift_promotors" /id="U2430" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=145 /SigmaFactorBS="ttagactggagtttttttgttttatcgGGTTTATgagagcgg tttaacAGGAAAAAAAAGAACACAGAacgaattaagcgatgagagcggacaaacgaaa g" /listShort="yugU, S1192, yuzH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2838696..2840360) /gene="yugT" /locus_tag="BSU_31290" /old_locus_tag="BSU31290" /EC_number="3.2.1.10" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 1761534; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oligo-1,6-glucosidase" /protein_id="NP_391007.2" /db_xref="EnsemblGenomes-Gn:BSU31290" /db_xref="EnsemblGenomes-Tr:CAB15118" /db_xref="GOA:O05242" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR032091" /db_xref="SubtiList:BG12372" /db_xref="UniProtKB/Swiss-Prot:O05242" /translation="MKKAWWKEAVVYQIYPRSFKDSNGDGIGDIQGIRTKLSYIKELG ADVIWICPLYDSPNADNGYDIRDYQNILSEFGTMEDFDELLGDIHDLDMKLIMDLVVN HTSDEHPWFIESRSSIHSEKRDWYIWKDGKNGKTPNNWESIFGGPAWEYDQKTSQYYL HLFDKKQPDLNWENEKVRNAVYDMINWWLDKGIDGFRVDAITHIKKKEGFPDMPNPKG LDYVPSFPYHMNADGIMDLLTELKENTFSRYPIMTVGEANGVAAKEAADWAGEKNGIF SMIFQFEHLGLWDVEINESIDIVAFKRILTDWQDSLEGIGWNALFMENHDQPRSVSVW GDDGVYLKESAKALSAVYFLMKGTPFIYQGQELGMTNVAFPSIEDYDDVALKRLYETK TAKGTSHEDVMKIVWKKGRDNSRTPMQWNAGPYAGFSEAKPWIGINENYKWLNAEAQK NDKTSVYHFYKSLIKLRQTYDVFINGTYELILPEDQQIFAYLRKNESHTALIAANLTG TPALFRHSGLPLSSDALVLSNIETEPHKHMTSVLLKPYEARIYLWC*" /label="yugT CDS" gene complement(2838696..2840360) /gene="yugT" /locus_tag="BSU_31290" /old_locus_tag="BSU31290" /label="yugT gene" downshifts complement(2838712) /Source="Nicolas_upshifts" /id="D1621" /incds=0 /nref=13 /ntot=38 /MaxReadThrough="1.79723" /MaxDrop="4.64379" /score="19.4176812" /energy="-6.5" /TU="NA" /idTUdmin="U2432" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2839668..2839687) /Source="Nicolas_upshift_promotors" /id="U2431" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.944055944055944" /psig="0.993006993006993" /xcortree=2467 /SigmaFactorBS="tttcctgacatgccgaatccaaaggGACTGGACtatgtccct tcctTTCCTTATCATATGAATGCTgacggcattatggatttgttaacagagctgaagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2839673) /Source="Nicolas_upshifts" /id="U2431" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.944055944055944" /psig="0.993006993006993" /xcortree=2467 /SigmaFactorBS="tttcctgacatgccgaatccaaaggGACTGGACtatgtccct tcctTTCCTTATCATATGAATGCTgacggcattatggatttgttaacagagctgaagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2839701..2839708) /Source="Nicolas_upshift_promotors" /id="U2431" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.944055944055944" /psig="0.993006993006993" /xcortree=2467 /SigmaFactorBS="tttcctgacatgccgaatccaaaggGACTGGACtatgtccct tcctTTCCTTATCATATGAATGCTgacggcattatggatttgttaacagagctgaagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2840385..2840403) /Source="Nicolas_upshift_promotors" /id="U2432" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1123 /SigmaFactorBS="gctgttttttgtgtcatcaagtcatttcttaaaaagcaATGC TGtaaagacctttttctACATAGGATATATAAGAACggtacactgggaaggagtggct g" /listShort="yugT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2840402) /Source="Nicolas_upshifts" /id="U2432" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1123 /SigmaFactorBS="gctgttttttgtgtcatcaagtcatttcttaaaaagcaATGC TGtaaagacctttttctACATAGGATATATAAGAACggtacactgggaaggagtggct g" /listShort="yugT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2840419..2840424) /Source="Nicolas_upshift_promotors" /id="U2432" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1123 /SigmaFactorBS="gctgttttttgtgtcatcaagtcatttcttaaaaagcaATGC TGtaaagacctttttctACATAGGATATATAAGAACggtacactgggaaggagtggct g" /listShort="yugT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2840487..2841776) /gene="yugS" /locus_tag="BSU_31300" /old_locus_tag="BSU31300" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="NP_391008.2" /db_xref="EnsemblGenomes-Gn:BSU31300" /db_xref="EnsemblGenomes-Tr:CAB15119" /db_xref="GOA:O05241" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR002550" /db_xref="InterPro:IPR005170" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG12371" /db_xref="UniProtKB/Swiss-Prot:O05241" /translation="MLILQLIAIFVLIGITAVFVAAEFAIVKIRGSKINQLIESGDSR ALAAHKIISNLDEYLSACQLGITITALGLGWLGEPTFERFLHPLFTMTGIPEPFNHIV TFVVAFIIVTFLHVVMGELAPKTVSIQKAEAVSLWIAKPLIWFYKITYPFIKALNGSA SFLVKLFGFHSVKEHQVVISEEELRLILSESYEKGEINQSEFRYVNKIFEFDNRVARE IMIPRTEIAVISLEQSLEEAIHHIINERYTRYPVIKDDKDHILGIINSKDMFKAYFLG QPIKLNQIMRPVIRVIESIPVQQLLIRMQKERIHMAILVDEYGGTAGLVTVEDIIEEI VGEIRDEYDQDETPHILKKGEHHYVMDGKALIDEVNDLLDIAIENEEIDTIAGWLLTQ KMELKAGDVIHAEGCEFKILDAEDHHIRFVEIKKTDF*" /label="yugS CDS" gene complement(2840487..2841776) /gene="yugS" /locus_tag="BSU_31300" /old_locus_tag="BSU31300" /label="yugS gene" downshifts complement(2840496) /Source="Nicolas_upshifts" /id="D1622" /incds=0 /nref=5 /ntot=28 /MaxReadThrough="0.89237" /MaxDrop="3.67001" /score="3.60520478" /energy="-7.6" /TU="NA" /idTUdmin="U2434" /TUdmin=13 /isTUend="TRUE" /label="downshifts" promotor_-35 2841305..2841311 /Source="Nicolas_upshift_promotors" /id="U2433" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=254 /SigmaFactorBS="aagccaaacaatttcacaagaaaacttgcagagcCGTTTAAt gctttaataaacGGGTACGTGATTTTATAAAaccagatcagcggctttgcaatccata a" /listShort="S1193" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2841325..2841343 /Source="Nicolas_upshift_promotors" /id="U2433" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=254 /SigmaFactorBS="aagccaaacaatttcacaagaaaacttgcagagcCGTTTAAt gctttaataaacGGGTACGTGATTTTATAAAaccagatcagcggctttgcaatccata a" /listShort="S1193" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2841331 /Source="Nicolas_upshifts" /id="U2433" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=254 /SigmaFactorBS="aagccaaacaatttcacaagaaaacttgcagagcCGTTTAAt gctttaataaacGGGTACGTGATTTTATAAAaccagatcagcggctttgcaatccata a" /listShort="S1193" /GFF_Attribute="listLong" /label="upshifts" S_feature 2841335..2841987 /Source="Nicolas_S_feature" /locus_tag="new_3217011_3217663" /HighExp="Etha, Sw, Gly, Salt, BC, B60, Heat, S8, B36, HiTm" /AntisenseName="yugS" /AntisenseCor="0.12310225183111501" /AntisenseRegPval="-1.4" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1193" CDS complement(2841820..2842497) /gene="yugP" /locus_tag="BSU_31310" /old_locus_tag="BSU31310" /function="16.6: Maintain" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16704729, 16850406, 24383880; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent protease/peptidase" /protein_id="NP_391009.1" /db_xref="EnsemblGenomes-Gn:BSU31310" /db_xref="EnsemblGenomes-Tr:CAB15120" /db_xref="GOA:O05248" /db_xref="InterPro:IPR007395" /db_xref="SubtiList:BG12370" /db_xref="UniProtKB/Swiss-Prot:O05248" /translation="MLFIFLTIAALGLSFWAQFKVKSNFEKYSKVEASSGRTGAETAR RILDINGLYDVPVEPVRGTLTDHYDPTRRVVRLSEPVYYGRSISAISVASHEVGHALQ HQESYGALVLRHKIFPVVNFASGVAPLLFLGGMLLGSLNLIGLGIILFSAAVFFQLIT LPVEFNASSRAKQIIVSEGFIRNNEENGVNKVLSAAALTYVAAALVSLFELLRFVMIF LNGRDEN*" /label="yugP CDS" gene complement(2841820..2842497) /gene="yugP" /locus_tag="BSU_31310" /old_locus_tag="BSU31310" /label="yugP gene" downshifts complement(2841830) /Source="Nicolas_upshifts" /id="D1623" /incds=0 /nref=153 /ntot=249 /MaxReadThrough="3.51629" /MaxDrop="4.854" /score="33.0420688" /energy="-13" /TU="U2434,U2435" /idTUdmin="U2435" /TUdmin="-243" /isTUend="FALSE" /label="downshifts" S_feature 2842172..2842848 /Source="Nicolas_S_feature" /locus_tag="new_3217848_3218524" /HighExp="Sw, S8, Salt, BC, S7, Etha, Gly, B36, B60, LPhT" /AntisenseName="yuzI" /AntisenseCor="0.20035821815170399" /AntisenseRegPval="-3" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1194" promotor_-10 complement(2842532..2842551) /Source="Nicolas_upshift_promotors" /id="U2434" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig="0.999000999001" /xcortree=2033 /SigmaFactorBS="ctgattggattgtgtgctccaagccggaagaaaaagcgcatT TCTGTACacgagaaagaaaaCTCATTAAAATAATCGTAATagagaaatgatcatgaac a" /listShort="yugP, yugS" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2842539..2842802) /gene="yuzI" /locus_tag="BSU_31319" /old_locus_tag="BSU31319" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16704729; Product type f : factor" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097777.1" /db_xref="EnsemblGenomes-Gn:BSU31319" /db_xref="EnsemblGenomes-Tr:CAX52683" /db_xref="GOA:C0H3Q4" /db_xref="UniProtKB/Swiss-Prot:C0H3Q4" /translation="MTIFQRTIVVLIGTQLAASAVILFIFDLNSYNHFSGSFSWLHFL KELAGSFAFYLFSAGLFFLLIGLCAPSRKKKRISVHEKENSLK*" /label="yuzI CDS" gene complement(2842539..2842802) /gene="yuzI" /locus_tag="BSU_31319" /old_locus_tag="BSU31319" /label="yuzI gene" upshifts complement(2842553) /Source="Nicolas_upshifts" /id="U2434" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig="0.999000999001" /xcortree=2033 /SigmaFactorBS="ctgattggattgtgtgctccaagccggaagaaaaagcgcatT TCTGTACacgagaaagaaaaCTCATTAAAATAATCGTAATagagaaatgatcatgaac a" /listShort="yugP, yugS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2842565..2842572) /Source="Nicolas_upshift_promotors" /id="U2434" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig="0.999000999001" /xcortree=2033 /SigmaFactorBS="ctgattggattgtgtgctccaagccggaagaaaaagcgcatT TCTGTACacgagaaagaaaaCTCATTAAAATAATCGTAATagagaaatgatcatgaac a" /listShort="yugP, yugS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2842814..2842832) /Source="Nicolas_upshift_promotors" /id="U2435" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1079 /SigmaFactorBS="cccacttccggtgatgtttttcaaaaaatgtacaaAACATAt aaaaccggatttctCCATAAACTAAAACAAAAAggatgaaaaagatgacgatctttca a" /listShort="yuzI, yugP, yugS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2842828) /Source="Nicolas_upshifts" /id="U2435" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1079 /SigmaFactorBS="cccacttccggtgatgtttttcaaaaaatgtacaaAACATAt aaaaccggatttctCCATAAACTAAAACAAAAAggatgaaaaagatgacgatctttca a" /listShort="yuzI, yugP, yugS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2842848..2842853) /Source="Nicolas_upshift_promotors" /id="U2435" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1079 /SigmaFactorBS="cccacttccggtgatgtttttcaaaaaatgtacaaAACATAt aaaaccggatttctCCATAAACTAAAACAAAAAggatgaaaaagatgacgatctttca a" /listShort="yuzI, yugP, yugS" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2842849..2843181 /gene="mstX" /locus_tag="BSU_31321" /old_locus_tag="BSU31321" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15731457, 23737939, 25297828" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15731457, 23737939, 25297828; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="atypical membrane-integrating regulator of biofilm formation (Mistic protein)" /protein_id="YP_003097778.1" /db_xref="EnsemblGenomes-Gn:BSU31321" /db_xref="EnsemblGenomes-Tr:CAX52684" /db_xref="GOA:Q5BU39" /db_xref="InterPro:IPR021078" /db_xref="PDB:1YGM" /db_xref="UniProtKB/Swiss-Prot:Q5BU39" /translation="MFCTFFEKHHRKWDILLEKSTGVMEAMKVTSEEKEQLSTAIDRM NEGLDAFIQLYNESEIDEPLIQLDDDTAELMKQARDMYGQEKLNEKLNTIIKQILSIS VSEEGEKE*" /label="mstX CDS" gene 2842849..2843181 /gene="mstX" /locus_tag="BSU_31321" /old_locus_tag="BSU31321" /label="mstX gene" promotor_-35 2842866..2842872 /Source="Nicolas_upshift_promotors" /id="U2436" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=1012 /SigmaFactorBS="tccggttttatatgttttgtacatttttTGAAAAAcatcacc ggaagtgGGACATACTGTTAGAAAAaagcacgggtgtgatggaagctatgaaagtgac g" /listShort="mstX, yugO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2842887..2842904 /Source="Nicolas_upshift_promotors" /id="U2436" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=1012 /SigmaFactorBS="tccggttttatatgttttgtacatttttTGAAAAAcatcacc ggaagtgGGACATACTGTTAGAAAAaagcacgggtgtgatggaagctatgaaagtgac g" /listShort="mstX, yugO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2842898 /Source="Nicolas_upshifts" /id="U2436" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=1012 /SigmaFactorBS="tccggttttatatgttttgtacatttttTGAAAAAcatcacc ggaagtgGGACATACTGTTAGAAAAaagcacgggtgtgatggaagctatgaaagtgac g" /listShort="mstX, yugO" /GFF_Attribute="listLong" /label="upshifts" CDS 2843178..2844164 /gene="kbfO" /locus_tag="BSU_31322" /old_locus_tag="BSU31322" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16704729, 23737939, 25297828" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16704729, 23737939, 25297828; Product type t: transporter" /codon_start=1 /transl_table=11 /product="potassium channel protein involved in biofilm formation" /protein_id="NP_391010.3" /db_xref="EnsemblGenomes-Gn:BSU31322" /db_xref="EnsemblGenomes-Tr:CAB15121" /db_xref="GOA:Q795M8" /db_xref="InterPro:IPR003148" /db_xref="InterPro:IPR013099" /db_xref="InterPro:IPR028325" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12369" /db_xref="UniProtKB/Swiss-Prot:Q795M8" /translation="MKSNRIFISWLRWPLFIRIGVIILCLILLFGQIIYILEPKQFTS VFEGIWWAVVTVSTVGYGDYVPHTPLGQAAGILLILSGASFVTAYFATLSAAAFSRQH RYIEGKVAYKGRDHIILIGWNEKTNRLLKDLQLAAPSKTVVLIDESLTEGPLIENVHF IRGHAADDGTLKRANITEAESVMITADQYKSETDADMLSVLTLLSVKGLNPLAYCIVE ILTDRFVTNAERAGANQIIGTSEFISRAMLQHYQVKLRPSKQQNGIKLTLDQHVELLA VPDELKGAAYKTCVLYFLDHNTTIIGIQKKEGPMLSPPLTYKVLETDQFLAI*" /label="kbfO CDS" gene 2843178..2844164 /gene="kbfO" /locus_tag="BSU_31322" /old_locus_tag="BSU31322" /label="kbfO gene" downshifts complement(2844139) /Source="Nicolas_upshifts" /id="D1624" /incds=0 /nref=44 /ntot=128 /MaxReadThrough="0.617940000000001" /MaxDrop="4.76695" /score="21.5904825" /energy="-11.3" /TU="NA" /idTUdmin="U2437" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2844161..2844565) /gene="yugN" /locus_tag="BSU_31330" /old_locus_tag="BSU31330" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391011.1" /db_xref="EnsemblGenomes-Gn:BSU31330" /db_xref="EnsemblGenomes-Tr:CAB15122" /db_xref="InterPro:IPR014967" /db_xref="InterPro:IPR036491" /db_xref="SubtiList:BG12368" /db_xref="UniProtKB/Swiss-Prot:O05246" /translation="MIPIPSAIDGQSFLLQELEQVMKPLGYVINGGWEYDHGYFDYKI DDRDGYLFLRIPVNAVQGSLDERGAAVRIGTPFMLRQVFQADVDDHAEGGPFQSLFNQ FSEPERRDAEIDPAFLDIGASLVKELEDVLLH*" /label="yugN CDS" gene complement(2844161..2844565) /gene="yugN" /locus_tag="BSU_31330" /old_locus_tag="BSU31330" /label="yugN gene" S_feature complement(2844566..2844624) /Source="Nicolas_S_feature" /locus_tag="new_3220242_3220300_c" /HighExp="M0t90, M40t90, S6, S8, S7, T0.30H, Lbstat, M9-stat, T1.30H, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, Sig-, SigA" /TUshortPSig="0.686, 0.141, 0.984" /TUlongSig="SigA" /TUlongPSig="0.988" /label="S1195" CDS complement(2844625..2844996) /gene="yugM" /locus_tag="BSU_31340" /old_locus_tag="BSU31340" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_391012.1" /db_xref="EnsemblGenomes-Gn:BSU31340" /db_xref="EnsemblGenomes-Tr:CAB15123" /db_xref="GOA:O05245" /db_xref="SubtiList:BG12367" /db_xref="UniProtKB/Swiss-Prot:O05245" /translation="MFMKQLVKHLIIAGFSAAILSFLISFDAVYTGFSSSFGGTLSHF FIHSFLLIGLPLALFTDAVHRILHLKRTHTLFTKLGLYATVVYVSWDSAVWLAAAMAV YFLIECAFFPVGRAKETTISM*" /label="yugM CDS" gene complement(2844625..2844996) /gene="yugM" /locus_tag="BSU_31340" /old_locus_tag="BSU31340" /label="yugM gene" CDS complement(2845055..2846407) /gene="pgi" /locus_tag="BSU_31350" /old_locus_tag="BSU31350" /EC_number="5.3.1.9" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 4214896, 4275311, 11489127, 19052382, 21453533, 22720735, 24705866; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucose-6-phosphate isomerase" /protein_id="NP_391013.2" /db_xref="EnsemblGenomes-Gn:BSU31350" /db_xref="EnsemblGenomes-Tr:CAB15124" /db_xref="GOA:P80860" /db_xref="InterPro:IPR001672" /db_xref="InterPro:IPR018189" /db_xref="InterPro:IPR035476" /db_xref="InterPro:IPR035482" /db_xref="SubtiList:BG12366" /db_xref="UniProtKB/Swiss-Prot:P80860" /translation="MTHVRFDYSKALTFFNEHELTYLRDFVKTAHHNIHEKTGAGSDF LGWVDLPEHYDKEEFARIKKSAEKIKSDSDVLLVVGIGGSYLGARAAIEALNHAFYNT LPKAKRGNPQVIFIGNNISSSYMRDVMDLLEDVDFSINVISKSGTTTEPAIAFRIFRK LLEEKYGKEEAKARIYATTDKERGALKTLSNEEGFESFVIPDDVGGRYSVLTAVGLLP IAVSGVNIDDMMKGALDASKDFATSELEDNPAYQYAVVRNVLYNKGKTIEMLINYEPA LQYFAEWWKQLFGESEGKDEKGIYPSSANYSTDLHSLGQYVQEGRRDLFETVLNVEKP KHELTIEEADNDLDGLNYLAGKTVDFVNKKAFQGTMLAHTDGNVPNLIVNIPELNAYT FGYLVYFFEKACAMSGYLLGVNPFDQPGVEAYKVNMFALLGKPGFEEKKAELEKRLED *" /label="pgi CDS" gene complement(2845055..2846407) /gene="pgi" /locus_tag="BSU_31350" /old_locus_tag="BSU31350" /label="pgi gene" downshifts complement(2845066) /Source="Nicolas_upshifts" /id="D1625" /incds=0 /nref=90 /ntot=198 /MaxReadThrough="6.86736" /MaxDrop="4.4585" /score="24.139293" /energy="-16.8" /TU="U2437,U2438,U2439" /idTUdmin="U2441" /TUdmin=19 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2845222..2845240) /Source="Nicolas_upshift_promotors" /id="U2437" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.686313686313686" /psig="0.686313686313686" /xcortree=764 /SigmaFactorBS="tgcttgcccatacagacggaaatgttccgaacttaatcGTTA ACattcctgagctgaatGCATATACTTTTGGATACCttgtatatttcttcgaaaaagc c" /listShort="yugM, S1195, yugN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2845239) /Source="Nicolas_upshifts" /id="U2437" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.686313686313686" /psig="0.686313686313686" /xcortree=764 /SigmaFactorBS="tgcttgcccatacagacggaaatgttccgaacttaatcGTTA ACattcctgagctgaatGCATATACTTTTGGATACCttgtatatttcttcgaaaaagc c" /listShort="yugM, S1195, yugN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2845256..2845261) /Source="Nicolas_upshift_promotors" /id="U2437" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.686313686313686" /psig="0.686313686313686" /xcortree=764 /SigmaFactorBS="tgcttgcccatacagacggaaatgttccgaacttaatcGTTA ACattcctgagctgaatGCATATACTTTTGGATACCttgtatatttcttcgaaaaagc c" /listShort="yugM, S1195, yugN" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2846380) /Source="Nicolas_upshifts" /id="U2438" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.325674325674326" /psig="0.140859140859141" /xcortree=1777 /SigmaFactorBS="tgaaaacattataccgttatggagggacaagcaatgacgcat gtacGCTTTGACTACTcaaaagcgttgactttcttcaacgaacatgaacttacatacc t" /listShort="pgi, yugM, S1195, yugN" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(2846383..2846394) /Source="Nicolas_upshift_promotors" /id="U2438" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.325674325674326" /psig="0.140859140859141" /xcortree=1777 /SigmaFactorBS="tgaaaacattataccgttatggagggacaagcaatgacgcat gtacGCTTTGACTACTcaaaagcgttgactttcttcaacgaacatgaacttacatacc t" /listShort="pgi, yugM, S1195, yugN" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(2846439..2846458) /Source="Nicolas_upshift_promotors" /id="U2439" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.984015984015984" /xcortree=2224 /SigmaFactorBS="aatccagtcattccgccctttcttcttgaCTTGatttcacag ataagTTCATATAAAGTGAAAGATGaaaacattataccgttatggagggacaagcaat g" /listShort="pgi, yugM, S1195, yugN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2846445) /Source="Nicolas_upshifts" /id="U2439" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.984015984015984" /xcortree=2224 /SigmaFactorBS="aatccagtcattccgccctttcttcttgaCTTGatttcacag ataagTTCATATAAAGTGAAAGATGaaaacattataccgttatggagggacaagcaat g" /listShort="pgi, yugM, S1195, yugN" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2846447..2846518) /Source="Nicolas_S_feature" /locus_tag="new_3222123_3222194_c" /HighExp="Etha, H2O2, Paraq, Oxctl, G180, G150, dia5, dia15, G135, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 0.988" /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S1196" promotor_-35 complement(2846473..2846476) /Source="Nicolas_upshift_promotors" /id="U2439" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.984015984015984" /xcortree=2224 /SigmaFactorBS="aatccagtcattccgccctttcttcttgaCTTGatttcacag ataagTTCATATAAAGTGAAAGATGaaaacattataccgttatggagggacaagcaat g" /listShort="pgi, yugM, S1195, yugN" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2846519..2847691) /gene="bdhK" /locus_tag="BSU_31360" /old_locus_tag="BSU31360" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1385386, 1809209, 2673038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADH-dependent butanol dehydrogenase subunit" /protein_id="NP_391014.1" /db_xref="EnsemblGenomes-Gn:BSU31360" /db_xref="EnsemblGenomes-Tr:CAB15125" /db_xref="GOA:O05240" /db_xref="InterPro:IPR001670" /db_xref="InterPro:IPR018211" /db_xref="SubtiList:BG12365" /db_xref="UniProtKB/Swiss-Prot:O05240" /translation="MENFTYYNPTKLIFGKGQLEQLRKEFKRYGKNVLLVYGGGSIKR NGLYDQVTGILKEEGAVVHELSGVEPNPRLATVEKGIGLCREHDIDFLLAVGGGSVID CTKAIAAGVKYDGDAWDIFSKKVTAEDALPFGTVLTLAATGSEMNPDSVITNWETNEK FVWGSNVTHPRFSILDPENTFTVPENQTVYGMVDMMSHVFEQYFHNVENTPLQDRMCF AVLQTVIETAPKLLEDLENYELRETILYAGTIALNGTLQMGYFGDWASHTMEHAVSAV YDIPHAGGLAILFPNWMRYTLDTNVGRFKNLMLNMFDIDTEGKTDKEIALEGIDKLSA FWTSLGAPSRLADYNIGEEKLELIADIAAKEMEHGGFGNFQKLNKDDVLAILRASL*" /label="bdhK CDS" gene complement(2846519..2847691) /gene="bdhK" /locus_tag="BSU_31360" /old_locus_tag="BSU31360" /label="bdhK gene" S_feature 2846854..2847775 /Source="Nicolas_S_feature" /locus_tag="new_3222530_3223451" /HighExp="S6, S7, S8, BT, S5, C30, LBGstat, B36, G135, G150" /AntisenseName="yugK" /AntisenseCor="4.31382473780575E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1197" promotor_-10 complement(2847724..2847743) /Source="Nicolas_upshift_promotors" /id="U2440" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.81018981018981" /psig="0.999000999001" /xcortree=2474 /SigmaFactorBS="taaaaaaaggggaaatagccgtttggctgcttccCTTTttct tttttgtcaactTATGTTACAATGGAAAATCTgttttttaccagcatcatttggaggt t" /listShort="yugK, S1196" /listLong="pgi" /label="promotor_-10" upshifts complement(2847737) /Source="Nicolas_upshifts" /id="U2440" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.81018981018981" /psig="0.999000999001" /xcortree=2474 /SigmaFactorBS="taaaaaaaggggaaatagccgtttggctgcttccCTTTttct tttttgtcaactTATGTTACAATGGAAAATCTgttttttaccagcatcatttggaggt t" /listShort="yugK, S1196" /listLong="pgi" /label="upshifts" promotor_-35 complement(2847760..2847763) /Source="Nicolas_upshift_promotors" /id="U2440" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.81018981018981" /psig="0.999000999001" /xcortree=2474 /SigmaFactorBS="taaaaaaaggggaaatagccgtttggctgcttccCTTTttct tttttgtcaactTATGTTACAATGGAAAATCTgttttttaccagcatcatttggaggt t" /listShort="yugK, S1196" /listLong="pgi" /label="promotor_-35" CDS complement(2847795..2848958) /gene="bdhJ" /locus_tag="BSU_31370" /old_locus_tag="BSU31370" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1385386, 2673038, 9643546, 11466286, 15317791; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADH-dependent butanol dehydrogenase" /protein_id="NP_391015.1" /db_xref="EnsemblGenomes-Gn:BSU31370" /db_xref="EnsemblGenomes-Tr:CAB15126" /db_xref="GOA:O05239" /db_xref="InterPro:IPR001670" /db_xref="InterPro:IPR018211" /db_xref="SubtiList:BG12364" /db_xref="UniProtKB/Swiss-Prot:O05239" /translation="MQNFTYWNPTKLIFGRGEVERLPEELKPYGKNVLLVYGGGSIKR SGLYDQVIEQLNKAGATVHELAGVEPNPRVSTVNKGVAICKEQNIDFLLAVGGGSVID CTKAIAAGAKYDGDAWDIVTKKHQPKDALPFGTVLTLAATGSEMNSGSVITNWETKEK YGWGSPLVFPKFSILDPVNTFTVPKNHTIYGMVDMMSHVFEQYFHHVSNTPYQDRMCE SLLRTVIETAPKLINDLENYELRETILYTGTIALNGMLSMGARGDWATHNIEHAVSAV YDIPHAGGLAILFPNWMRHTLSENPARMKQLAVRVFDVEEAGKTDEEIALEGIDKLSA FWTSLGAPNRLADYDINDEQLDTIADKAMANGTFGQFKSLNKEDVLSILKASL*" /label="bdhJ CDS" gene complement(2847795..2848958) /gene="bdhJ" /locus_tag="BSU_31370" /old_locus_tag="BSU31370" /label="bdhJ gene" downshifts complement(2847810) /Source="Nicolas_upshifts" /id="D1626" /incds=0 /nref=167 /ntot=237 /MaxReadThrough="6.69366" /MaxDrop="4.74696" /score="28.8200012" /energy="-13.4" /TU="U2441" /idTUdmin="U2444" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2848973..2848992) /Source="Nicolas_upshift_promotors" /id="U2441" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.803196803196803" /psig="0.988011988011988" /xcortree=1943 /SigmaFactorBS="ataaaaccatctggtatgctgatcggtgagagctgatTGCTT TACatgtggtgaggacaTTCTGCATAATAAAAAATCTaaggaggagatgtcatgcaaa a" /listShort="yugJ, yugK, S1196, pgi" /listLong="yugM, S1195, yugN" /label="promotor_-10" upshifts complement(2848991) /Source="Nicolas_upshifts" /id="U2441" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.803196803196803" /psig="0.988011988011988" /xcortree=1943 /SigmaFactorBS="ataaaaccatctggtatgctgatcggtgagagctgatTGCTT TACatgtggtgaggacaTTCTGCATAATAAAAAATCTaaggaggagatgtcatgcaaa a" /listShort="yugJ, yugK, S1196, pgi" /listLong="yugM, S1195, yugN" /label="upshifts" S_feature complement(2848993..2849148) /Source="Nicolas_S_feature" /locus_tag="new_3224669_3224824_c" /HighExp="S8, S7, S4, S5, S6, LoTm, Cold, LBGtran, G180, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.25658199999999998" /TUshortSig="SigGF, SigA" /TUshortPSig="0.679, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1198" promotor_-35 complement(2849007..2849014) /Source="Nicolas_upshift_promotors" /id="U2441" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.803196803196803" /psig="0.988011988011988" /xcortree=1943 /SigmaFactorBS="ataaaaccatctggtatgctgatcggtgagagctgatTGCTT TACatgtggtgaggacaTTCTGCATAATAAAAAATCTaaggaggagatgtcatgcaaa a" /listShort="yugJ, yugK, S1196, pgi" /listLong="yugM, S1195, yugN" /label="promotor_-35" promotor_-35 2849044..2849050 /Source="Nicolas_upshift_promotors" /id="U2442" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=195 /SigmaFactorBS="atcagctctcaccgatcagcataccagatGGTTTTAttttgc aaggtgctGGGAAAGAAGCTGATATAAgcgagggcaggccagcttccctcatatggag a" /listShort="S1199, yuzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2849065..2849083 /Source="Nicolas_upshift_promotors" /id="U2442" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=195 /SigmaFactorBS="atcagctctcaccgatcagcataccagatGGTTTTAttttgc aaggtgctGGGAAAGAAGCTGATATAAgcgagggcaggccagcttccctcatatggag a" /listShort="S1199, yuzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2849075 /Source="Nicolas_upshifts" /id="U2442" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=195 /SigmaFactorBS="atcagctctcaccgatcagcataccagatGGTTTTAttttgc aaggtgctGGGAAAGAAGCTGATATAAgcgagggcaggccagcttccctcatatggag a" /listShort="S1199, yuzA" /GFF_Attribute="listLong" /label="upshifts" S_feature 2849076..2849134 /Source="Nicolas_S_feature" /locus_tag="new_3224752_3224810" /HighExp="Etha, Salt, Heat, M9-stat, LPhT, Sw, Gly, BC, HiTm, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1199" promotor_-35 2849121..2849127 /Source="Nicolas_upshift_promotors" /id="U2443" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.814185814185814" /psig="0.814185814185814" /xcortree=734 /SigmaFactorBS="tgatataagcgagggcaggccagcttccctcatatggagaat gcaTGTATAGattctccaatatgTCACAATCTATAactgttttaataattcatggagg a" /listShort="yuzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2849123..2849134) /Source="Nicolas_upshift_promotors" /id="U2444" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.679320679320679" /psig="0.679320679320679" /xcortree=897 /SigmaFactorBS="aattctttgaatggtactcatgttttgcaacctcctccatga attattaaaacaGTTATAGattgtgacatattGGAGAATCTATAcatgcattctccat a" /listShort="S1198, yugJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2849136 /Source="Nicolas_upshifts" /id="U2443" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.814185814185814" /psig="0.814185814185814" /xcortree=734 /SigmaFactorBS="tgatataagcgagggcaggccagcttccctcatatggagaat gcaTGTATAGattctccaatatgTCACAATCTATAactgttttaataattcatggagg a" /listShort="yuzA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2849141..2849152 /Source="Nicolas_upshift_promotors" /id="U2443" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.814185814185814" /psig="0.814185814185814" /xcortree=734 /SigmaFactorBS="tgatataagcgagggcaggccagcttccctcatatggagaat gcaTGTATAGattctccaatatgTCACAATCTATAactgttttaataattcatggagg a" /listShort="yuzA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2849148..2849154) /Source="Nicolas_upshift_promotors" /id="U2444" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.679320679320679" /psig="0.679320679320679" /xcortree=897 /SigmaFactorBS="aattctttgaatggtactcatgttttgcaacctcctccatga attattaaaacaGTTATAGattgtgacatattGGAGAATCTATAcatgcattctccat a" /listShort="S1198, yugJ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2849148) /Source="Nicolas_upshifts" /id="U2444" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.679320679320679" /psig="0.679320679320679" /xcortree=897 /SigmaFactorBS="aattctttgaatggtactcatgttttgcaacctcctccatga attattaaaacaGTTATAGattgtgacatattGGAGAATCTATAcatgcattctccat a" /listShort="S1198, yugJ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2849150..2849461) /Source="Nicolas_S_feature" /locus_tag="new_3224826_3225137_c" /HighExp="Cold, LBGtran, LoTm, G180, LBGexp, dia15, G135, H2O2, Paraq, Oxctl" /AntisenseName="yuzA" /AntisenseCor="-0.50065532030853999" /AntisenseRegPval="-17.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1200" CDS 2849188..2849424 /gene="yuzA" /locus_tag="BSU_31380" /old_locus_tag="BSU31380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391016.1" /db_xref="EnsemblGenomes-Gn:BSU31380" /db_xref="EnsemblGenomes-Tr:CAB15127" /db_xref="GOA:O32087" /db_xref="InterPro:IPR007211" /db_xref="SubtiList:BG14050" /db_xref="UniProtKB/Swiss-Prot:O32087" /translation="MSTIQRICLVLTIIGAINWGLIGFFQFDLVAAIFGGQGSALSRI IYGLVGIAGLINLGLLFKPNEERSREEAANPEMR*" /label="yuzA CDS" gene 2849188..2849424 /gene="yuzA" /locus_tag="BSU_31380" /old_locus_tag="BSU31380" /label="yuzA gene" downshifts 2849384 /Source="Nicolas_upshifts" /id="D1627" /incds=0 /nref=3 /ntot=45 /MaxReadThrough="7.39676" /MaxDrop="2.87922" /score="13.9936296" /energy="-12" /TU="U2442,U2443" /idTUdmin="U2442" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" downshifts 2849450 /Source="Nicolas_upshifts" /id="D1628" /incds=0 /nref=25 /ntot=56 /MaxReadThrough="1.29261" /MaxDrop="7.50276" /score="13.9936296" /energy="-12" /TU="NA" /idTUdmin="U2442" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2849502..2849894) /gene="yugI" /locus_tag="BSU_31390" /old_locus_tag="BSU31390" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9862121, 16014871, 19152054, 19636895; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA degradation protein; putative phosphorylase or nucleotidyl transferase; general stress protein" /protein_id="NP_391017.1" /db_xref="EnsemblGenomes-Gn:BSU31390" /db_xref="EnsemblGenomes-Tr:CAB15128" /db_xref="GOA:P80870" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR022967" /db_xref="PDB:2K4K" /db_xref="SubtiList:BG12363" /db_xref="UniProtKB/Swiss-Prot:P80870" /translation="MAAKFEVGSVYTGKVTGLQAYGAFVALDEETQGLVHISEVTHGF VKDINEHLSVGDEVQVKVLAVDEEKGKISLSIRATQAAPEKKESKPRKPKAAQVSEEA STPQGFNTLKDKLEEWIEMSNRKDLIKK*" /label="yugI CDS" gene complement(2849502..2849894) /gene="yugI" /locus_tag="BSU_31390" /old_locus_tag="BSU31390" /label="yugI gene" downshifts complement(2849506) /Source="Nicolas_upshifts" /id="D1629" /incds=0 /nref=232 /ntot=268 /MaxReadThrough="5.9665" /MaxDrop="6.0195" /score="13.5952751" /energy="-15.6" /TU="U2445" /idTUdmin="U2448" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2849936..2849955) /Source="Nicolas_upshift_promotors" /id="U2445" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.921078921078921" /psig=1 /xcortree=2503 /SigmaFactorBS="taaacctgattttttataaaaaagttttCTTTGcggaaataa gacatgTGTGATATAATTTTAAATTGcgtataaacagatatttaatttaacttaggag t" /listShort="yugI, S1200, S1198, yugJ" /listLong="yugK, S1196, pgi, yugM" /label="promotor_-10" upshifts complement(2849943) /Source="Nicolas_upshifts" /id="U2445" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.921078921078921" /psig=1 /xcortree=2503 /SigmaFactorBS="taaacctgattttttataaaaaagttttCTTTGcggaaataa gacatgTGTGATATAATTTTAAATTGcgtataaacagatatttaatttaacttaggag t" /listShort="yugI, S1200, S1198, yugJ" /listLong="yugK, S1196, pgi, yugM" /label="upshifts" S_feature complement(2849945..2850095) /Source="Nicolas_S_feature" /locus_tag="new_3225621_3225771_c" /HighExp="G180, C30, G135, LBGexp, G150, Oxctl, HPh, Cold, BMM, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1201" promotor_-35 complement(2849971..2849975) /Source="Nicolas_upshift_promotors" /id="U2445" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.921078921078921" /psig=1 /xcortree=2503 /SigmaFactorBS="taaacctgattttttataaaaaagttttCTTTGcggaaataa gacatgTGTGATATAATTTTAAATTGcgtataaacagatatttaatttaacttaggag t" /listShort="yugI, S1200, S1198, yugJ" /listLong="yugK, S1196, pgi, yugM" /label="promotor_-35" promotor_-35 2849998..2850004 /Source="Nicolas_upshift_promotors" /id="U2446" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.662337662337662" /psig="0.662337662337662" /xcortree=1396 /SigmaFactorBS="tcacacatgtcttatttccgcaaagaaaacttttttataaaa aatcaGGTTTATgcacagcaaaaaggGGGTAAACTGAAAATACCAaaggctttctagt a" /listShort="S1202" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2850011..2850995 /Source="Nicolas_S_feature" /locus_tag="new_3225687_3226671" /HighExp="LoTm, C30, Salt, S7, S5, S8, Sw, S3, C90, S6" /AntisenseName="yugH" /AntisenseCor="-0.45629591209076698" /AntisenseRegPval="-14.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.662" /TUlongSig="NA" /TUlongPSig="NA" /label="S1202" upshifts 2850011 /Source="Nicolas_upshifts" /id="U2446" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.662337662337662" /psig="0.662337662337662" /xcortree=1396 /SigmaFactorBS="tcacacatgtcttatttccgcaaagaaaacttttttataaaa aatcaGGTTTATgcacagcaaaaaggGGGTAAACTGAAAATACCAaaggctttctagt a" /listShort="S1202" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2850019..2850037 /Source="Nicolas_upshift_promotors" /id="U2446" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.662337662337662" /psig="0.662337662337662" /xcortree=1396 /SigmaFactorBS="tcacacatgtcttatttccgcaaagaaaacttttttataaaa aatcaGGTTTATgcacagcaaaaaggGGGTAAACTGAAAATACCAaaggctttctagt a" /listShort="S1202" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2850096..2851256) /gene="yugH" /locus_tag="BSU_31400" /old_locus_tag="BSU31400" /EC_number="2.6.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12670965; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aspartate aminotransferase" /protein_id="NP_391018.2" /db_xref="EnsemblGenomes-Gn:BSU31400" /db_xref="EnsemblGenomes-Tr:CAB15129" /db_xref="GOA:Q795M6" /db_xref="InterPro:IPR004838" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG12362" /db_xref="UniProtKB/Swiss-Prot:Q795M6" /translation="MTSYLSDYVQQIKPSGIRKFFDLAATMEGVISLGVGEPDFVTAW NVREASILSLEQGYTSYTANAGLYSLREEISRYLSNRFDLSYSPDNELIVTVGASQAL DIAIRAIVNPGEEVIIPEPCFVAYDALVSLAGGIPVHVHTTADKGFKATAADFEAAVT EKTKAILICSPSNPTGSVYSKEELNEIAEFAKKHDVIVLADEIYAELTYDEEFTSIAA LPGMKERTVVISGFSKAFAMTGWRLGFAAAPSLLRDAMLKIHQYAMMCAPAMAQFAAL EGLKNGMEDVEKMKKSYRRRRNLFVESLNEIGLSCHHPGGAFYAFPSIKSMGMSSEQF AEELLTQEKVAVVPGSVFGPSGEGYIRCSYATSIEQLQEALVRMKRFLHKTT*" /label="yugH CDS" gene complement(2850096..2851256) /gene="yugH" /locus_tag="BSU_31400" /old_locus_tag="BSU31400" /label="yugH gene" promotor_-35 2851148..2851154 /Source="Nicolas_upshift_promotors" /id="U2447" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.964035964035964" /psig="0.003996003996004" /xcortree=33 /SigmaFactorBS="tgcttgcttcgcggacattccatgcggtaacaaaatcaggct CGCCGACgcctaaagaaatgACGCCttccatcgttgccgccaaatcaaagaatttgcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2851166 /Source="Nicolas_upshifts" /id="U2447" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.964035964035964" /psig="0.003996003996004" /xcortree=33 /SigmaFactorBS="tgcttgcttcgcggacattccatgcggtaacaaaatcaggct CGCCGACgcctaaagaaatgACGCCttccatcgttgccgccaaatcaaagaatttgcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2851168..2851172 /Source="Nicolas_upshift_promotors" /id="U2447" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.964035964035964" /psig="0.003996003996004" /xcortree=33 /SigmaFactorBS="tgcttgcttcgcggacattccatgcggtaacaaaatcaggct CGCCGACgcctaaagaaatgACGCCttccatcgttgccgccaaatcaaagaatttgcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2851257..2851757) /gene="yugG" /locus_tag="BSU_31410" /old_locus_tag="BSU31410" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (Lrp/AsnC family)" /protein_id="NP_391019.1" /db_xref="EnsemblGenomes-Gn:BSU31410" /db_xref="EnsemblGenomes-Tr:CAB15130" /db_xref="GOA:O05236" /db_xref="InterPro:IPR000485" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR019887" /db_xref="InterPro:IPR019888" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12361" /db_xref="UniProtKB/Swiss-Prot:O05236" /translation="MKLTEKETEILEILDENSRADLETIAKMAGIPVNEVKTIIDKLE KEKVIIDYSAMIDWRKVDGHEGVTAMIDVKVTPKRGVGFDEVAERIYRFQEVESVYLM SGVYDLSVVIRGNSMSDVARFVSDKLSTLDSVVSTTTHFILKKYKHDGKVFETGDDDK RIVVSP*" /label="yugG CDS" gene complement(2851257..2851757) /gene="yugG" /locus_tag="BSU_31410" /old_locus_tag="BSU31410" /label="yugG gene" promotor_-10 complement(2851787..2851806) /Source="Nicolas_upshift_promotors" /id="U2448" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.996003996003996" /psig=1 /xcortree=2242 /SigmaFactorBS="ccctgaaattgtcaattctagcggaagtttctcctcgttttt tcTTAGCATTcgtcaaaaaaCGTGATATAATGTCATGAGAtttcttgacattgcaaag g" /listShort="yugG, yugH, S1201, yugI" /listLong="S1200, S1198, yugJ, yugK, S1196, pgi, yugM" /label="promotor_-10" promotor_-35 2851793..2851799 /Source="Nicolas_upshift_promotors" /id="U2449" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=876 /SigmaFactorBS="tcatttgattcacacctttgcaatgtcaagaaatctcatGAC ATTAtatcacgttttttgACGAATGCTAAGaaaaaacgaggagaaacttccgctagaa t" /listShort="S1203, yugF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2851808) /Source="Nicolas_upshifts" /id="U2448" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.996003996003996" /psig=1 /xcortree=2242 /SigmaFactorBS="ccctgaaattgtcaattctagcggaagtttctcctcgttttt tcTTAGCATTcgtcaaaaaaCGTGATATAATGTCATGAGAtttcttgacattgcaaag g" /listShort="yugG, yugH, S1201, yugI" /listLong="S1200, S1198, yugJ, yugK, S1196, pgi, yugM" /label="upshifts" promotor_-10 2851814..2851825 /Source="Nicolas_upshift_promotors" /id="U2449" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=876 /SigmaFactorBS="tcatttgattcacacctttgcaatgtcaagaaatctcatGAC ATTAtatcacgttttttgACGAATGCTAAGaaaaaacgaggagaaacttccgctagaa t" /listShort="S1203, yugF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2851814 /Source="Nicolas_upshifts" /id="U2449" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=876 /SigmaFactorBS="tcatttgattcacacctttgcaatgtcaagaaatctcatGAC ATTAtatcacgttttttgACGAATGCTAAGaaaaaacgaggagaaacttccgctagaa t" /listShort="S1203, yugF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2851817..2851824) /Source="Nicolas_upshift_promotors" /id="U2448" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.996003996003996" /psig=1 /xcortree=2242 /SigmaFactorBS="ccctgaaattgtcaattctagcggaagtttctcctcgttttt tcTTAGCATTcgtcaaaaaaCGTGATATAATGTCATGAGAtttcttgacattgcaaag g" /listShort="yugG, yugH, S1201, yugI" /listLong="S1200, S1198, yugJ, yugK, S1196, pgi, yugM" /label="promotor_-35" S_feature 2851826..2851904 /Source="Nicolas_S_feature" /locus_tag="new_3227502_3227580" /HighExp="S8, S5, S6, S7, S4, C30, Glucon, Pyr, nit, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1203" CDS 2851905..2852726 /gene="yugF" /locus_tag="BSU_31420" /old_locus_tag="BSU31420" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_391020.1" /db_xref="EnsemblGenomes-Gn:BSU31420" /db_xref="EnsemblGenomes-Tr:CAB15131" /db_xref="GOA:O05235" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR000639" /db_xref="InterPro:IPR013595" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12360" /db_xref="UniProtKB/Swiss-Prot:O05235" /translation="MEAVSPIRRFTVDGVNVYYEHYQNPGRQTLVCVHGFLSSAFSFR KVIPLLRDKYDIIALDLPPFGQSEKSRTFIYTYQNLAKLVIGILEHLQVKQAVLVGHS MGGQISLSAALQKPELFSKVVLLCSSGYLKRSHPTIIFGTHIPYFHLYIKRWLSKEGV MKNLLNVVHDKSLIDEEMIDGYGRPFQDEQIFKAMTRFIRHREGDLEPEQLKKMNKPA LLIWGEEDRIVPMEIGKRLHADLPNSVLYSLGQTGHLVPEERPELISEHIADFIK*" /label="yugF CDS" gene 2851905..2852726 /gene="yugF" /locus_tag="BSU_31420" /old_locus_tag="BSU31420" /label="yugF gene" downshifts 2852706 /Source="Nicolas_upshifts" /id="D1630" /incds=0 /nref=1 /ntot=12 /MaxReadThrough="1.0929" /MaxDrop="3.08755" /score="11.2614618" /energy="-6.6" /TU="NA" /idTUdmin="U2449" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2852753) /Source="Nicolas_upshifts" /id="D1631" /incds=0 /nref=20 /ntot=156 /MaxReadThrough="2.22671" /MaxDrop="4.10906" /score="25.9859375" /energy="-6.6" /TU="NA" /idTUdmin="U2451" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS complement(2852755..2853015) /gene="yugE" /locus_tag="BSU_31430" /old_locus_tag="BSU31430" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391021.2" /db_xref="EnsemblGenomes-Gn:BSU31430" /db_xref="EnsemblGenomes-Tr:CAB15132" /db_xref="InterPro:IPR015053" /db_xref="InterPro:IPR023162" /db_xref="SubtiList:BG12359" /db_xref="UniProtKB/Swiss-Prot:O05234" /translation="MEESHAVREMIKIIAKWDPFKYGEEFYETEAVDVVQAVYDENDP DLLAKSIQQIFETSFEQTLPIASCREVAGQLLFIKNSSSCTP*" /label="yugE CDS" gene complement(2852755..2853015) /gene="yugE" /locus_tag="BSU_31430" /old_locus_tag="BSU31430" /label="yugE gene" promotor_-35 2853005..2853008 /Source="Nicolas_upshift_promotors" /id="U2450" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.512487512487512" /psig="0.996003996003996" /xcortree=2691 /SigmaFactorBS="atgatcttaatcatttccctgaccgcatgaCTTTcttccata ttcatcACCGCTTATAATAAAATTTGcagttctatcttatcatagtgaagcttagaag a" /listShort="S1204, patB, kinB" /listLong="kapB" /label="promotor_-35" promotor_-10 2853023..2853042 /Source="Nicolas_upshift_promotors" /id="U2450" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.512487512487512" /psig="0.996003996003996" /xcortree=2691 /SigmaFactorBS="atgatcttaatcatttccctgaccgcatgaCTTTcttccata ttcatcACCGCTTATAATAAAATTTGcagttctatcttatcatagtgaagcttagaag a" /listShort="S1204, patB, kinB" /listLong="kapB" /label="promotor_-10" upshifts 2853035 /Source="Nicolas_upshifts" /id="U2450" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.512487512487512" /psig="0.996003996003996" /xcortree=2691 /SigmaFactorBS="atgatcttaatcatttccctgaccgcatgaCTTTcttccata ttcatcACCGCTTATAATAAAATTTGcagttctatcttatcatagtgaagcttagaag a" /listShort="S1204, patB, kinB" /listLong="kapB" /label="upshifts" S_feature 2853036..2853101 /Source="Nicolas_S_feature" /locus_tag="new_3228712_3228777" /HighExp="dia15, dia5, Lbexp, dia0, LBGtran, G180, Diami, H2O2, G150, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1204" promotor_-10 complement(2853041..2853060) /Source="Nicolas_upshift_promotors" /id="U2451" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=2500 /SigmaFactorBS="ttcattctgttaccccctcatgtatgttTATTCTTctaagct tcacTATGATAAGATAGAACTGCAaattttattataagcggtgatgaatatggaagaa a" /listShort="yugE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2853046) /Source="Nicolas_upshifts" /id="U2451" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=2500 /SigmaFactorBS="ttcattctgttaccccctcatgtatgttTATTCTTctaagct tcacTATGATAAGATAGAACTGCAaattttattataagcggtgatgaatatggaagaa a" /listShort="yugE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2853072..2853078) /Source="Nicolas_upshift_promotors" /id="U2451" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=2500 /SigmaFactorBS="ttcattctgttaccccctcatgtatgttTATTCTTctaagct tcacTATGATAAGATAGAACTGCAaattttattataagcggtgatgaatatggaagaa a" /listShort="yugE" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2853102..2854265 /gene="patB" /locus_tag="BSU_31440" /old_locus_tag="BSU31440" /EC_number="4.4.1.1" /EC_number="4.4.1.13" /EC_number="4.4.1.8" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15760717, 26337367, 28895253" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15760717, 26337367, 28895253; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous cystathionine / cystine beta-lyase /cysteine desulfhydrase" /protein_id="NP_391022.1" /db_xref="EnsemblGenomes-Gn:BSU31440" /db_xref="EnsemblGenomes-Tr:CAB15133" /db_xref="GOA:Q08432" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR027619" /db_xref="SubtiList:BG10744" /db_xref="UniProtKB/Swiss-Prot:Q08432" /translation="MNFDKREERLGTQSVKWDKTGELFGVTDALPMWVADMDFRAPEA ITEALKERLDHGIFGYTTPDQKTKDAVCGWMQNRHGWKVNPESITFSPGVVTALSMAV QAFTEPGDQVVVQPPVYTPFYHMVEKNGRHILHNPLLEKDGAYAIDFEDLETKLSDPS VTLFILCNPHNPSGRSWSREDLLKLGELCLEHGVTVVSDEIHSDLMLYGHKHTPFASL SDDFADISVTCAAPSKTFNIAGLQASAIIIPDRLKRAKFSASLQRNGLGGLNAFAVTA IEAAYSKGGPWLDELITYIEKNMNEAEAFLSTELPKVKMMKPDASYLIWLDFSAYGLS DAELQQRMLKKGKVILEPGTKYGPGGEGFMRLNAGCSLATLQDGLRRIKAALS*" /label="patB CDS" gene 2853102..2854265 /gene="patB" /locus_tag="BSU_31440" /old_locus_tag="BSU31440" /label="patB gene" promotor_-35 2854328..2854334 /Source="Nicolas_upshift_promotors" /id="U2452" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.852147852147852" /psig="0.999000999001" /xcortree=3054 /SigmaFactorBS="ttgtaaaggcgttcttaataaaggaattttatATTTTACttc taatatttAGTGTTATAATAGATTCATAttttatacgaaaggatttcacacgaatgga a" /listShort="kinB, kapB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2854346..2854365 /Source="Nicolas_upshift_promotors" /id="U2452" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.852147852147852" /psig="0.999000999001" /xcortree=3054 /SigmaFactorBS="ttgtaaaggcgttcttaataaaggaattttatATTTTACttc taatatttAGTGTTATAATAGATTCATAttttatacgaaaggatttcacacgaatgga a" /listShort="kinB, kapB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2854356 /Source="Nicolas_upshifts" /id="U2452" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.852147852147852" /psig="0.999000999001" /xcortree=3054 /SigmaFactorBS="ttgtaaaggcgttcttaataaaggaattttatATTTTACttc taatatttAGTGTTATAATAGATTCATAttttatacgaaaggatttcacacgaatgga a" /listShort="kinB, kapB" /GFF_Attribute="listLong" /label="upshifts" CDS 2854391..2855677 /gene="kinB" /locus_tag="BSU_31450" /old_locus_tag="BSU31450" /EC_number="2.7.13.3" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:9426145, 11069677, 15849754, 16850406, 26152584, 28583948" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9426145, 11069677, 15849754, 16850406, 26152584, 28583948; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="two-component sensor potassium-binding histidinekinase" /protein_id="NP_391023.2" /db_xref="EnsemblGenomes-Gn:BSU31450" /db_xref="EnsemblGenomes-Tr:CAB15134" /db_xref="GOA:Q08430" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10745" /db_xref="UniProtKB/Swiss-Prot:Q08430" /translation="MEILKDYLLHICFILFPILLYQVFWLGKPAILVPKINSGLVTLF ACGASVLCIIFPIHEMDYIQYGLQMIPVIICLFYISTASGLTVAASVLCFELLFYEPS AMFVFTLLPFLIIIPILFQKKWPFMSKAKKLLLSLLISCVEIFLFFASSWILSALNIL NFQKSGIFVYEAAVSGLFRSSVLLLSIYIIESIAENIALRSQLIHSEKMTIVSELAAS VAHEVRNPLTVVRGFVQLLFNDETLQNKSSADYKKLVLSELDRAQGIITNYLDMAKQQ LYEKEVFDLSALIKETSSLMVSYANYKSVTVEAETEPDLLIYGDATKLKQAVINLMKN SIEAVPHGKGMIHISAKRNGHTIMINITDNGVGMTDHQMQKLGEPYYSLKTNGTGLGL TVTFSIIEHHHGTISFNSSFQKGTTVTIKLPADLPH*" /label="kinB CDS" gene 2854391..2855677 /gene="kinB" /locus_tag="BSU_31450" /old_locus_tag="BSU31450" /label="kinB gene" S_feature complement(2855393..2856135) /Source="Nicolas_S_feature" /locus_tag="new_3231069_3231811_c" /HighExp="BT, S8, B36, S6, S7, S5, S3, S4, Cold, Pyr" /AntisenseName="kapB" /AntisenseCor="-0.71681066342113797" /AntisenseRegPval="-43" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigK" /TUshortPSig="0.709, 0.985" /TUlongSig="NA" /TUlongPSig="NA" /label="S1205" promotor_-35 2855672..2855679 /Source="Nicolas_upshift_promotors" /id="U2453" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.679320679320679" /psig="0.986013986013986" /xcortree=2010 /SigmaFactorBS="gcactacggtgaccattaagcttcccgctgatcttcctCACT AGCAaatcgattggaacTTTAATAGAATAAATGCGAGgtgatgacagatgagcacgtt t" /listShort="kapB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2855693..2855712 /Source="Nicolas_upshift_promotors" /id="U2453" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.679320679320679" /psig="0.986013986013986" /xcortree=2010 /SigmaFactorBS="gcactacggtgaccattaagcttcccgctgatcttcctCACT AGCAaatcgattggaacTTTAATAGAATAAATGCGAGgtgatgacagatgagcacgtt t" /listShort="kapB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2855694 /Source="Nicolas_upshifts" /id="U2453" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.679320679320679" /psig="0.986013986013986" /xcortree=2010 /SigmaFactorBS="gcactacggtgaccattaagcttcccgctgatcttcctCACT AGCAaatcgattggaacTTTAATAGAATAAATGCGAGgtgatgacagatgagcacgtt t" /listShort="kapB" /GFF_Attribute="listLong" /label="upshifts" CDS 2855723..2856109 /gene="kapB" /locus_tag="BSU_31460" /old_locus_tag="BSU31460" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9426145, 23335417" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9426145, 23335417; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor required for KinB signal transduction andactivation of the phosphorelay to sporulation" /protein_id="NP_391024.1" /db_xref="EnsemblGenomes-Gn:BSU31460" /db_xref="EnsemblGenomes-Tr:CAB15135" /db_xref="GOA:Q08429" /db_xref="InterPro:IPR014916" /db_xref="SubtiList:BG10746" /db_xref="UniProtKB/Swiss-Prot:Q08429" /translation="MSTFETGSIVKGFYKTGVYIGEITACRPQHYLVKVKAVLTHPAQ GDLHHPKQADVPFFHERKALAYGEQTNIPHHMVKPYDGEVPDYTESLREATAQMRAKL NEDGSEWAKRSLHNLDILEKEYFNRP*" /label="kapB CDS" gene 2855723..2856109 /gene="kapB" /locus_tag="BSU_31460" /old_locus_tag="BSU31460" /label="kapB gene" downshifts 2856091 /Source="Nicolas_upshifts" /id="D1632" /incds=0 /nref=209 /ntot=249 /MaxReadThrough="1.62013" /MaxDrop="5.57132" /score="1.97959632" /energy="-9.2" /TU="NA" /idTUdmin="U2452" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2856136..2856753) /gene="kapD" /locus_tag="BSU_31470" /old_locus_tag="BSU31470" /EC_number="3.1.-.-" /function="16.3: Control" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 27188294; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative exoribonuclease (3'-5')" /protein_id="NP_391025.1" /db_xref="EnsemblGenomes-Gn:BSU31470" /db_xref="EnsemblGenomes-Tr:CAB15136" /db_xref="GOA:O05231" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR013520" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG12358" /db_xref="UniProtKB/Swiss-Prot:O05231" /translation="MTTNSLLIIDFEFTMPDGKYSPQNFFPEIIEAGIVKSIDDEVVE TFSSYVRPKKFPKLTKRCKSFLKITQKQVDEGMRFEDFIRKLNELDPEKNSTIITWGN MDMKVLKQNCMFNHIPFPFKGEMRDLSLEYKNFFGDRTLTGLWKAAEEYGDSGTGTHH KALDDALTAYKLFKLVEQDKQYLEKPKPPTIGERIDLTELLKRAT*" /label="kapD CDS" gene complement(2856136..2856753) /gene="kapD" /locus_tag="BSU_31470" /old_locus_tag="BSU31470" /label="kapD gene" promotor_-10 complement(2856788..2856806) /Source="Nicolas_upshift_promotors" /id="U2454" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.709290709290709" /psig="0.709290709290709" /xcortree=1399 /SigmaFactorBS="cgaagcggctgggaaaattcattatttttagaaaatgaaGAA ATGtcgagaaggggaatTGATATACTATAAAGATAGcattttctgatcggaggaaagg c" /listShort="kapD, S1205" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2856805) /Source="Nicolas_upshifts" /id="U2454" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.709290709290709" /psig="0.709290709290709" /xcortree=1399 /SigmaFactorBS="cgaagcggctgggaaaattcattatttttagaaaatgaaGAA ATGtcgagaaggggaatTGATATACTATAAAGATAGcattttctgatcggaggaaagg c" /listShort="kapD, S1205" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2856807..2858895) /Source="Nicolas_S_feature" /locus_tag="new_3232483_3234571_c" /HighExp="S8, BT, B36, S7, S6, Pyr, C30, B60, S5, G135" /AntisenseName="yuxJ" /AntisenseCor="-0.168930816447634" /AntisenseRegPval="-2.2999999999999998" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.985" /TUlongSig="NA" /TUlongPSig="NA" /label="S1206" promotor_-35 complement(2856821..2856826) /Source="Nicolas_upshift_promotors" /id="U2454" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.709290709290709" /psig="0.709290709290709" /xcortree=1399 /SigmaFactorBS="cgaagcggctgggaaaattcattatttttagaaaatgaaGAA ATGtcgagaaggggaatTGATATACTATAAAGATAGcattttctgatcggaggaaagg c" /listShort="kapD, S1205" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2856869..2856872 /Source="Nicolas_upshift_promotors" /id="U2455" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.561438561438561" /psig=1 /xcortree=1539 /SigmaFactorBS="aaaataatgaattttcccagccgcttcgtttCTTTtaaattg tgaatcgTTTCTTTATAATTAGTAAGGaacccgaaataataagaaggtgatgttattt c" /listShort="yuxJ" /listLong="pbpD, yuxK" /label="promotor_-35" promotor_-10 2856887..2856906 /Source="Nicolas_upshift_promotors" /id="U2455" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.561438561438561" /psig=1 /xcortree=1539 /SigmaFactorBS="aaaataatgaattttcccagccgcttcgtttCTTTtaaattg tgaatcgTTTCTTTATAATTAGTAAGGaacccgaaataataagaaggtgatgttattt c" /listShort="yuxJ" /listLong="pbpD, yuxK" /label="promotor_-10" upshifts 2856898 /Source="Nicolas_upshifts" /id="U2455" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.561438561438561" /psig=1 /xcortree=1539 /SigmaFactorBS="aaaataatgaattttcccagccgcttcgtttCTTTtaaattg tgaatcgTTTCTTTATAATTAGTAAGGaacccgaaataataagaaggtgatgttattt c" /listShort="yuxJ" /listLong="pbpD, yuxK" /label="upshifts" CDS 2856964..2858142 /gene="yuxJ" /locus_tag="BSU_31480" /old_locus_tag="BSU31480" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 20011599; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative exporter induced in acid stress" /protein_id="NP_391026.2" /db_xref="EnsemblGenomes-Gn:BSU31480" /db_xref="EnsemblGenomes-Tr:CAB15137" /db_xref="GOA:P40760" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10976" /db_xref="UniProtKB/Swiss-Prot:P40760" /translation="MWLANFFVSASTTMIVPFLSLYIETLSSFSNGFVQRWSGYVFGI TFLMAFLVSPFWGRFGDKRGYKKILMATGTGIALSIFFMGFVTSVYQLFFLRMAMGLV TGFIPTSLAMISAQTPKSSAGKTLGTLQMGQVSGSLFGPLLGGMLADRFGFTYTFFIT SFVIFSSVLLVLFGVKEKHLAEKTAKRTSYSRKEVLSYIFHHPALWVMMLLTMLIQTG NFSIQPLLALYVNELHGPVNLAFFSGMAFSATGLGSLLLARKWGDLGDRYGHRRILIG LLLAASFFFIPQALASSLSVLLVFRFLFGMAMGGLLPCITAAIRVQAPGSIQGEVLGY NVSFRFLGNVLGPLLGGIISSHFTISATFYVTAFLFFAGACMLWIMQKLRKDSYAKAS *" /label="yuxJ CDS" gene 2856964..2858142 /gene="yuxJ" /locus_tag="BSU_31480" /old_locus_tag="BSU31480" /label="yuxJ gene" promotor_-35 2858180..2858186 /Source="Nicolas_upshift_promotors" /id="U2456" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=2246 /SigmaFactorBS="ttccgagaaaaaactaaggaatcttctaaatttaaccTTCTC GTaatctcaaaagAATGGTACGATATGGCTAGAatttaggagaaaagagagtgaccat g" /listShort="pbpD, yuxK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2858198..2858217 /Source="Nicolas_upshift_promotors" /id="U2456" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=2246 /SigmaFactorBS="ttccgagaaaaaactaaggaatcttctaaatttaaccTTCTC GTaatctcaaaagAATGGTACGATATGGCTAGAatttaggagaaaagagagtgaccat g" /listShort="pbpD, yuxK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2858203 /Source="Nicolas_upshifts" /id="U2456" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=2246 /SigmaFactorBS="ttccgagaaaaaactaaggaatcttctaaatttaaccTTCTC GTaatctcaaaagAATGGTACGATATGGCTAGAatttaggagaaaagagagtgaccat g" /listShort="pbpD, yuxK" /GFF_Attribute="listLong" /label="upshifts" CDS 2858235..2860109 /gene="pbpD" /locus_tag="BSU_31490" /old_locus_tag="BSU31490" /EC_number="2.-.-.-" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7961491, 9274030; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="penicillin-binding protein 4" /protein_id="NP_391027.2" /db_xref="EnsemblGenomes-Gn:BSU31490" /db_xref="EnsemblGenomes-Tr:CAB15138" /db_xref="GOA:P40750" /db_xref="InterPro:IPR001264" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR023346" /db_xref="InterPro:IPR036950" /db_xref="SubtiList:BG10977" /db_xref="UniProtKB/Swiss-Prot:P40750" /translation="MTMLRKIIGWILLLCIIPLFAFTVIASGKEVKQMKSLDQVLDKN IDLKDISLVQNSYMYDRDGSLVSEIVSDHENRVLVPFNKIPEEVKQIFLTSEDRHFYE HKGFDFMGMVRATASNVKDKKIDQGASTITQQLSRNLYLSHERSFSRKLTELAYSYQL EKKYTKNEILEAYLNTIYFNNGVYGVGSAAQFYFSKPLKSLTVGEMAFICAIPNNPTL YDPLKHFDYTKSRQERLLKGLKDAGVITDKELKKAVKQKIKLDVEKREDKYPDYVSYV NDEFTQLVSESEGFDKRLQKASGKQKEKIENELSARVSTLMKDGVKIYTALDPYMQNQ VVAQMNSKLPYADVQGGAAVINHQTHQIIALSGGKNYQKYDFNRAYQAYRQPGSSIKP LLDYGPYIEQTGATTSSTIDASKFCSKDYCPQNYNNRTYGTVTLDTAFKNSYNTPAIR MLDRVGIQKAFSYIEPYHFAKLVDSDYLLPAALGGFTNGMTPLEMTKAYTTFGNSGSY TPSHAITKVTDLKGKTLYKWNDKATQIFSVRTNMQLKKLMSSVVKSGTGKKAYFNAPY IGGKTGTSNDYHDMWFVGLTDTYTMGVWVGKDTPTSVEYLHSISPQLSIWKGTLQAAY *" /label="pbpD CDS" gene 2858235..2860109 /gene="pbpD" /locus_tag="BSU_31490" /old_locus_tag="BSU31490" /label="pbpD gene" promotor_-10 complement(2858875..2858894) /Source="Nicolas_upshift_promotors" /id="U2457" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1344 /SigmaFactorBS="cttttagccctttaagtaaacgttcttgacggcttttcGTGT AGTCAAaatgcttgagaggATCATATAATGTAGGGTTATtaggtatagcacagataaa a" /listShort="S1206, kapD, S1205" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2858895) /Source="Nicolas_upshifts" /id="U2457" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1344 /SigmaFactorBS="cttttagccctttaagtaaacgttcttgacggcttttcGTGT AGTCAAaatgcttgagaggATCATATAATGTAGGGTTATtaggtatagcacagataaa a" /listShort="S1206, kapD, S1205" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2858908..2858917) /Source="Nicolas_upshift_promotors" /id="U2457" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1344 /SigmaFactorBS="cttttagccctttaagtaaacgttcttgacggcttttcGTGT AGTCAAaatgcttgagaggATCATATAATGTAGGGTTATtaggtatagcacagataaa a" /listShort="S1206, kapD, S1205" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2860130..2860543 /gene="yuxK" /locus_tag="BSU_31500" /old_locus_tag="BSU31500" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26335199; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thiol-disulfide oxidoreductase" /protein_id="NP_391028.1" /db_xref="EnsemblGenomes-Gn:BSU31500" /db_xref="EnsemblGenomes-Tr:CAB15139" /db_xref="InterPro:IPR007263" /db_xref="SubtiList:BG10978" /db_xref="UniProtKB/Swiss-Prot:P40761" /translation="MTSEQIPNRVLLFDGVCNLCNGAVQFIIKRDPDGLISFTSLQSE TGQSLLKKSGLPTDRFDSFVFIEDGQVYTKSTAAIKVFRHLRGPWRLFVLFFAVPKPV RDMVYSFIAKNRYKWFGKKNECMLPSPSIKKRFLP*" /label="yuxK CDS" gene 2860130..2860543 /gene="yuxK" /locus_tag="BSU_31500" /old_locus_tag="BSU31500" /label="yuxK gene" downshifts 2860535 /Source="Nicolas_upshifts" /id="D1633" /incds=0 /nref=1 /ntot=254 /MaxReadThrough="5.05064" /MaxDrop="3.14634" /score="-3.58105315" /energy="-11.5" /TU="U2456" /idTUdmin="U2456" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(2860746..2861303) /gene="yufK" /locus_tag="BSU_31510" /old_locus_tag="BSU31510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_391029.2" /db_xref="EnsemblGenomes-Gn:BSU31510" /db_xref="EnsemblGenomes-Tr:CAB15140" /db_xref="GOA:O05249" /db_xref="InterPro:IPR035289" /db_xref="SubtiList:BG12346" /db_xref="UniProtKB/Swiss-Prot:O05249" /translation="MKNTYLTGYFPLIAILLFSSSLSISTSLYALKMLSSFGMYDGML DYFSEKGIRLALFAAFALLYFMVLSALKLIANTVTELSLLFFANDPEGNNLKKLRMGS MIYLGGGILSFVLLQNVIWIVIWFAVVTLAYFVFTVYRIYSTLSLMSLVGFILLELLF WFTFVIGILFIFIKLYNSIMASLPV*" /label="yufK CDS" gene complement(2860746..2861303) /gene="yufK" /locus_tag="BSU_31510" /old_locus_tag="BSU31510" /label="yufK gene" misc_feature 2860767..2860786 /Source="Nicolas_upshift_promotors" /id="U2458" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.845154845154845" /psig="0.878121878121878" /xcortree=2785 /SigmaFactorBS="tctgaccaccaaacgctgaaatggctagcttacacaggtaag ctagccatTATGCTATTATAAAGCTTGAtaaatatgaacagaataccgataacaaagg t" /listShort="S1207" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2860777 /Source="Nicolas_upshifts" /id="U2458" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.845154845154845" /psig="0.878121878121878" /xcortree=2785 /SigmaFactorBS="tctgaccaccaaacgctgaaatggctagcttacacaggtaag ctagccatTATGCTATTATAAAGCTTGAtaaatatgaacagaataccgataacaaagg t" /listShort="S1207" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(2860787) /Source="Nicolas_upshifts" /id="D1634" /incds=0 /nref=10 /ntot=201 /MaxReadThrough="3.90201" /MaxDrop="3.94501" /score="-6.00543052" /energy="-18.5" /TU="U2459" /idTUdmin="U2459" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" S_feature 2860799..2861480 /Source="Nicolas_S_feature" /locus_tag="new_3236475_3237156" /HighExp="Diami, Cold, LBGstat, H2O2, Lbtran, Gly, M0t90, GM 10, GM-0.2, dia15" /AntisenseName="yufK" /AntisenseCor="0.32488342936044701" /AntisenseRegPval="-7.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.878" /TUlongSig="NA" /TUlongPSig="NA" /label="S1207" promotor_-10 complement(2861329..2861348) /Source="Nicolas_upshift_promotors" /id="U2459" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=2604 /SigmaFactorBS="gtaaaaaggagaaaaaatggaataatttaTCTTGtcaatgtg ttttaagTCCTCCATAATAAATGAGGTagattatagaaagggacttttttatatgaaa a" /listShort="yufK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2861337) /Source="Nicolas_upshifts" /id="U2459" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=2604 /SigmaFactorBS="gtaaaaaggagaaaaaatggaataatttaTCTTGtcaatgtg ttttaagTCCTCCATAATAAATGAGGTagattatagaaagggacttttttatatgaaa a" /listShort="yufK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2861364..2861368) /Source="Nicolas_upshift_promotors" /id="U2459" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=2604 /SigmaFactorBS="gtaaaaaggagaaaaaatggaataatttaTCTTGtcaatgtg ttttaagTCCTCCATAATAAATGAGGTagattatagaaagggacttttttatatgaaa a" /listShort="yufK" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2861481..2863082 /gene="maeL" /locus_tag="BSU_31520" /old_locus_tag="BSU31520" /EC_number="2.7.13.3" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 12949159, 12949160, 22001508" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 12949159, 12949160, 22001508; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [MaeM]" /protein_id="NP_391030.1" /db_xref="EnsemblGenomes-Gn:BSU31520" /db_xref="EnsemblGenomes-Tr:CAB15141" /db_xref="GOA:O05250" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR013767" /db_xref="InterPro:IPR016120" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033463" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12347" /db_xref="UniProtKB/Swiss-Prot:O05250" /translation="MKKTLKLQTRLTIFVCIVVLIALLITFFTVGAQTTKRIRDQEKA TALQTAEMVAEAPMTAAALESGKKQKELQSYTKRVQKITGTEFVVVMDMNGIRKTHPD PSKIGKKFRGGDESEVLKGHVHISTASGTLGKSQRAFVPVYAENGKQVGAVAVGITVN EIDEVISHSLRPLYFIICVSIFVGVIGAVIVARTVKNIMYGLEPYEIATLLEERSAML ESTKEGILAVDEHGKIKLANAEAKRLFVKMGINTNPIDQDVDDILPKSRLKKVIETKK PLQDRDVRINGLELVFNEVPIQLKGQTVGAIATFRDKTEVKHLAEQLSGVKMYANALR AQSHEFMNKLHVILGLVQLKEYDDLGDYIKDIAIQQKSETSEIINDVKSSVLAGFLLG KQSFIREQGANLDIECNGVIPNAADPSVIHELITIIGNLINNGLDAVADMPKKQITMS MRFHNSILDIEITDTGAGMSEEDQAKVFEQGYSTKGKNRGFGLYFTQQSIENLKGQMI LTSEKNEGTTFSIRIPYEPKEENHD*" /label="maeL CDS" gene 2861481..2863082 /gene="maeL" /locus_tag="BSU_31520" /old_locus_tag="BSU31520" /label="maeL gene" CDS 2863075..2863782 /gene="maeM" /locus_tag="BSU_31530" /old_locus_tag="BSU31530" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 12949159, 12949160, 22001508" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 12949159, 12949160, 22001508; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator for malate metabolism [MaeL]" /protein_id="NP_391031.1" /db_xref="EnsemblGenomes-Gn:BSU31530" /db_xref="EnsemblGenomes-Tr:CAB15142" /db_xref="GOA:O05251" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR024187" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12348" /db_xref="UniProtKB/Swiss-Prot:O05251" /translation="MINVLIVEDDPMVGELNKRYLSQIDGFQLKGIASSFQSALHILG EHHIDLILLDIYMPGKNGLELLTELRAQNEAVDVIVISAASELDVIKKTLRYGAVDYL IKPFEFERFQTALSDYRRKQKVYSTHRNMSQKELDAELFQKKEATEKVQLPKGLTKST LKLIWSSIQSFENESFTTEDLAKHTEISQVSIRKYLKFLEDIQVLNVEMAYGTIGRPV FQYNVNNSNINGIKQYL*" /label="maeM CDS" gene 2863075..2863782 /gene="maeM" /locus_tag="BSU_31530" /old_locus_tag="BSU31530" /label="maeM gene" downshifts 2863767 /Source="Nicolas_upshifts" /id="D1635" /incds=0 /nref=173 /ntot=245 /MaxReadThrough="1.97489" /MaxDrop="5.86018" /score="19.9464971" /energy="-15.3" /TU="NA" /idTUdmin="U2458" /TUdmin=2660 /isTUend="FALSE" /label="downshifts" promotor_-35 2863946..2863953 /Source="Nicolas_upshift_promotors" /id="U2460" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.999000999001" /xcortree=2875 /SigmaFactorBS="aattctaaaaatagataatttttaaaaaattatgcgaaattc TATTTATTtcttattagttaaaTGATAAATTATGATTGGTTAgttgatcccgaaaaac t" /listShort="S1208, yufN, yufO, yufP, yufQ, S1209, maeN" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2863964..2864253 /Source="Nicolas_S_feature" /locus_tag="new_3239640_3239929" /HighExp="T1.30H, T1.0H, T2.30H, T2.0H, M9-stat, S1, T3.0H, T3.30H, T0.30H, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1208" upshifts 2863964 /Source="Nicolas_upshifts" /id="U2460" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.999000999001" /xcortree=2875 /SigmaFactorBS="aattctaaaaatagataatttttaaaaaattatgcgaaattc TATTTATTtcttattagttaaaTGATAAATTATGATTGGTTAgttgatcccgaaaaac t" /listShort="S1208, yufN, yufO, yufP, yufQ, S1209, maeN" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2863968..2863987 /Source="Nicolas_upshift_promotors" /id="U2460" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.999000999001" /xcortree=2875 /SigmaFactorBS="aattctaaaaatagataatttttaaaaaattatgcgaaattc TATTTATTtcttattagttaaaTGATAAATTATGATTGGTTAgttgatcccgaaaaac t" /listShort="S1208, yufN, yufO, yufP, yufQ, S1209, maeN" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2864254..2865333 /gene="nupN" /locus_tag="BSU_31540" /old_locus_tag="BSU31540" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:21926227, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21926227, 22720735; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="lipoprotein involved in guanosine transport" /protein_id="NP_391032.2" /db_xref="EnsemblGenomes-Gn:BSU31540" /db_xref="EnsemblGenomes-Tr:CAB15143" /db_xref="GOA:O05252" /db_xref="InterPro:IPR003760" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG12349" /db_xref="UniProtKB/Swiss-Prot:O05252" /translation="MNKRKIGLAMSLVIAAGTILGACGNSEKSSGSGEGKNKFSVAMV TDVGGVDDKSFNQSAWEGIQAFGKENGLKKGKNGYDYLQSKSDADYTTNLNKLARENF DLIYGVGYLMEDSISEIADQRKNTNFAIIDAVVDKDNVASITFKEQEGSFLVGVAAAL SSKSGKIGFVGGMESELIKKFEVGFRAGVQAVNPKAVVEVKYAGGFDKADVGKATAES MYKSGVDVIYHSAGATGTGVFTEAKNLKKEDPKRDVWVIGVDKDQYAEGQVEGTDDNV TLTSMVKKVDTVVEDVTKKASDGKFPGGETLTYGLDQDGVGISPSKQNLSDDVIKAVD KWKKKIIDGLEIPATEKELKTFKAE*" /label="nupN CDS" gene 2864254..2865333 /gene="nupN" /locus_tag="BSU_31540" /old_locus_tag="BSU31540" /label="nupN gene" CDS 2865409..2866941 /gene="nupO" /locus_tag="BSU_31550" /old_locus_tag="BSU31550" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:21926227, 25875741" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21926227, 25875741; Product type t: transporter" /codon_start=1 /transl_table=11 /product="guanosine ABC transporter (ATP-binding protein)" /protein_id="NP_391033.1" /db_xref="EnsemblGenomes-Gn:BSU31550" /db_xref="EnsemblGenomes-Tr:CAB15144" /db_xref="GOA:O05253" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12350" /db_xref="UniProtKB/Swiss-Prot:O05253" /translation="MEYVIEMLNIRKAFPGIVANDNINLQVKKGEIHALLGENGAGKS TLMNVLFGLYQPERGEIRVRGEKVHINSPNKANDLGIGMVHQHFMLVDTFTVAENIIL GKEPKKFGRIDRKRAGQEVQDISDRYGLQIHPEAKAADISVGMQQRAEILKTLYRGAD ILIFDEPTAVLTPHEIKELMQIMKNLVKEGKSIILITHKLKEIMEICDRVTVIRKGKG IKTLDVRDTNQDELASLMVGREVSFKTEKRAAQPGAEVLAIDGITVKDTRGIETVRDL SLSVKAGEIVGIAGVDGNGQSELIEAVTGLRKTDSGTITLNGKQIQNLTPRKITESGI GHIPQDRHKHGLVLDFPIGENILLQSYYKKPYSALGVLHKGEMYKKARSLITEYDVRT PDEYTHARALSGGNQQKAIIGREIDRNPDLLIAAQPTRGLDVGAIEFVHKKLIEQRDA GKAVLLLSFELEEIMNLSDRIAVIFEGRIIASVNPQETTEQELGLLMAGSTQKEAGKA NG*" /label="nupO CDS" gene 2865409..2866941 /gene="nupO" /locus_tag="BSU_31550" /old_locus_tag="BSU31550" /label="nupO gene" CDS 2866934..2867980 /gene="nupP" /locus_tag="BSU_31560" /old_locus_tag="BSU31560" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 21926227" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 21926227; Product type t: transporter" /codon_start=1 /transl_table=11 /product="permease of ABC guanosine transporter" /protein_id="NP_391034.1" /db_xref="EnsemblGenomes-Gn:BSU31560" /db_xref="EnsemblGenomes-Tr:CAB15145" /db_xref="GOA:O05254" /db_xref="InterPro:IPR001851" /db_xref="InterPro:IPR002229" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12351" /db_xref="UniProtKB/Swiss-Prot:O05254" /translation="MVKRLSHLLVPLIAIILGLAAGALIMLVSGYSVASGYSALWNGI FGEIYYVGETIRQITPYILSGLAVAFAFRTGLFNIGVEGQLLVGWTAAVWVGTAFDGP AYIHLPLALITAAAAGGLWGFIPGILKARFYVHEVIVTIMMNYIALHMTNYIISNVLT DHQDKTGKIHESASLRSPFLEQITDYSRLHLGIIVALLAAVIMWFIINKSTKGFELRA VGFNQHASQYAGMSVRKNIMTSMLISGAFAGLAGAMEGLGTFEYAAVKGAFTGVGFDG IAVALLGGNTAVGVVLAACLLGGLKIGALNMPIESGVPSEVVDIVIAIIILFVASSYA IRFVMGKLKKKGAN*" /label="nupP CDS" gene 2866934..2867980 /gene="nupP" /locus_tag="BSU_31560" /old_locus_tag="BSU31560" /label="nupP gene" CDS 2867981..2868940 /gene="nupQ" /locus_tag="BSU_31570" /old_locus_tag="BSU31570" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 21926227" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 21926227; Product type t: transporter" /codon_start=1 /transl_table=11 /product="permease of ABC guanosine transporter" /protein_id="NP_391035.1" /db_xref="EnsemblGenomes-Gn:BSU31570" /db_xref="EnsemblGenomes-Tr:CAB15146" /db_xref="GOA:O05255" /db_xref="InterPro:IPR001851" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12352" /db_xref="UniProtKB/Swiss-Prot:O05255" /translation="MDIVQILSIIVPATLVYAAPLILTALGGVFSERSGVVNIGLEGL MIIGAFTSVLFNLFFGQELGAAAPWLSLLAAMAAGALFSLIHAAAAISFRADQTVSGV AINMLALGATLFIVKLIYGKAQTDKIPEPFYKTKIPGLGDIPVLGKIFFSDVYYTSIL AIALAFISWFILFKTPFGLRIRSVGEHPMAADTMGINVYKMRYIGVMISGLFGGLGGG VYASTIALDFTHSTISGQGFIALAALVFGKWHPIGALGAALFFGFAQSLSIIGSLLPL FKDIPNVYMLMAPYILTILALTGFIGRADAPKANGVPYIKGKR*" /label="nupQ CDS" gene 2867981..2868940 /gene="nupQ" /locus_tag="BSU_31570" /old_locus_tag="BSU31570" /label="nupQ gene" S_feature 2868941..2869062 /Source="Nicolas_S_feature" /locus_tag="new_3244617_3244738" /HighExp="S1, BT, M9-stat, T1.30H, S2, LoTm, T1.0H, T2.30H, T2.0H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1209" promotor_-35 2869035..2869038 /Source="Nicolas_upshift_promotors" /id="U2461" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.944055944055944" /psig="0.996003996003996" /xcortree=1755 /SigmaFactorBS="taattgtttattagttttttaacttaaaaaaATATgaagtgt taacgctTTCTTGTAGACTGTAACAAAcaatacatgggggtgtatgacatgggagcaa t" /listShort="maeN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2869053..2869072 /Source="Nicolas_upshift_promotors" /id="U2461" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.944055944055944" /psig="0.996003996003996" /xcortree=1755 /SigmaFactorBS="taattgtttattagttttttaacttaaaaaaATATgaagtgt taacgctTTCTTGTAGACTGTAACAAAcaatacatgggggtgtatgacatgggagcaa t" /listShort="maeN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2869064 /Source="Nicolas_upshifts" /id="U2461" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.944055944055944" /psig="0.996003996003996" /xcortree=1755 /SigmaFactorBS="taattgtttattagttttttaacttaaaaaaATATgaagtgt taacgctTTCTTGTAGACTGTAACAAAcaatacatgggggtgtatgacatgggagcaa t" /listShort="maeN" /GFF_Attribute="listLong" /label="upshifts" CDS 2869094..2870440 /gene="maeN" /locus_tag="BSU_31580" /old_locus_tag="BSU31580" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11004162, 12949159, 15849754, 16850406, 17183219, 19087206, 19114526, 20011599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11004162, 12949159, 15849754, 16850406, 17183219, 19087206, 19114526, 20011599; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Na+/malate symporter" /protein_id="NP_391036.1" /db_xref="EnsemblGenomes-Gn:BSU31580" /db_xref="EnsemblGenomes-Tr:CAB15147" /db_xref="GOA:O05256" /db_xref="InterPro:IPR004679" /db_xref="InterPro:IPR018025" /db_xref="SubtiList:BG12353" /db_xref="UniProtKB/Swiss-Prot:O05256" /translation="MGAIPKTGTISPEQKDSQEKNLFQKIWSWEIGVIPLPLYTVLAV IIILAAYYNELPANMLGGFAIIMILGVFLGDIGQRIPILKDIGGPAILSLFVPSFLVF YNVLNSTSLDAVTNLMKTSNFLYFYIACLVVGSILGMNRIVLIQGFIRMFVPLVAGTI AAVAAGILVGFIFGYSAYDSFFFVVVPIIAGGIGEGILPLSIAYSQILGSSADVFVSQ LVPAAIIGNVFAIICAALMKKLGDKRPDLNGNGRLVKSKKANEIFNQKEAEAKIDFKL MGAGVLLACTFFIFGGLLEKFIFIPGAILMIISAAAVKYANILPKKMEEGAYQLYKFI SSSFTWPLMVGLGILFIPLDDVASVISIPFVIICISVVIAMIGSGYFVGKLMNMYPVE SAIVTCCHSGLGGTGDVAILSASGRMGLMPFAQISTRLGGAGTVICATVLLRFFTS*" /label="maeN CDS" gene 2869094..2870440 /gene="maeN" /locus_tag="BSU_31580" /old_locus_tag="BSU31580" /label="maeN gene" downshifts 2870423 /Source="Nicolas_upshifts" /id="D1636" /incds=0 /nref=68 /ntot=109 /MaxReadThrough="0.286069999999999" /MaxDrop="6.51197" /score="36.240717" /energy="-12.2" /TU="NA" /idTUdmin="U2461" /TUdmin="-12" /isTUend="TRUE" /label="downshifts" CDS complement(2870476..2870691) /gene="yufS" /locus_tag="BSU_31590" /old_locus_tag="BSU31590" /function="16.8: Protect" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16845009; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative bacteriocin" /protein_id="NP_391037.1" /db_xref="EnsemblGenomes-Gn:BSU31590" /db_xref="EnsemblGenomes-Tr:CAB15148" /db_xref="GOA:O05257" /db_xref="SubtiList:BG12354" /db_xref="UniProtKB/Swiss-Prot:O05257" /translation="MKTKVVMCSGLFCSVFAGAFMLNQYDGRSGVAACDEWELYLLEH HLSARMSETESKDLPFGPREYIRIVNK*" /label="yufS CDS" gene complement(2870476..2870691) /gene="yufS" /locus_tag="BSU_31590" /old_locus_tag="BSU31590" /label="yufS gene" promotor_-35 2870631..2870637 /Source="Nicolas_upshift_promotors" /id="U2462" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=877 /SigmaFactorBS="ccgccacaccgctgcgcccgtcatattgattcaacaTGAATG CccctgcaaatactGAGCAGAATAAAcctgagcacatcacgacttttgttttcacatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2870651..2870662 /Source="Nicolas_upshift_promotors" /id="U2462" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=877 /SigmaFactorBS="ccgccacaccgctgcgcccgtcatattgattcaacaTGAATG CccctgcaaatactGAGCAGAATAAAcctgagcacatcacgacttttgttttcacatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2870655 /Source="Nicolas_upshifts" /id="U2462" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=877 /SigmaFactorBS="ccgccacaccgctgcgcccgtcatattgattcaacaTGAATG CccctgcaaatactGAGCAGAATAAAcctgagcacatcacgacttttgttttcacatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2870702..2870720) /Source="Nicolas_upshift_promotors" /id="U2463" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.696303696303696" /psig="0.696303696303696" /xcortree=1197 /SigmaFactorBS="aaataagtctaacaaaaaagaggttattTGTATAtttaaaat caatcctGATCAAGCTGAAGGAAAGGagctggtcatgtgaaaacaaaagtcgtgatgt g" /listShort="yufS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2870709) /Source="Nicolas_upshifts" /id="U2463" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.696303696303696" /psig="0.696303696303696" /xcortree=1197 /SigmaFactorBS="aaataagtctaacaaaaaagaggttattTGTATAtttaaaat caatcctGATCAAGCTGAAGGAAAGGagctggtcatgtgaaaacaaaagtcgtgatgt g" /listShort="yufS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2870734..2870741 /Source="Nicolas_upshift_promotors" /id="U2464" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96103896103896" /psig="0.998001998001998" /xcortree=1758 /SigmaFactorBS="ccagctcctttccttcagcttgatcaggattgattttaAATA TACAaataacctctttttTGTTAGACTTATTTTGAGGTcaaaagaactcataaaaatc c" /listShort="S1210, S1211, mrpA, mrpB, mrpC, mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2870736..2870741) /Source="Nicolas_upshift_promotors" /id="U2463" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.696303696303696" /psig="0.696303696303696" /xcortree=1197 /SigmaFactorBS="aaataagtctaacaaaaaagaggttattTGTATAtttaaaat caatcctGATCAAGCTGAAGGAAAGGagctggtcatgtgaaaacaaaagtcgtgatgt g" /listShort="yufS" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2870756..2870851 /Source="Nicolas_S_feature" /locus_tag="new_3246432_3246527" /HighExp="G180, Diami, G150, Oxctl, G135, H2O2, Paraq, MG 60, MG 15, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1210" promotor_-10 2870756..2870775 /Source="Nicolas_upshift_promotors" /id="U2464" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96103896103896" /psig="0.998001998001998" /xcortree=1758 /SigmaFactorBS="ccagctcctttccttcagcttgatcaggattgattttaAATA TACAaataacctctttttTGTTAGACTTATTTTGAGGTcaaaagaactcataaaaatc c" /listShort="S1210, S1211, mrpA, mrpB, mrpC, mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2870756 /Source="Nicolas_upshifts" /id="U2464" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96103896103896" /psig="0.998001998001998" /xcortree=1758 /SigmaFactorBS="ccagctcctttccttcagcttgatcaggattgattttaAATA TACAaataacctctttttTGTTAGACTTATTTTGAGGTcaaaagaactcataaaaatc c" /listShort="S1210, S1211, mrpA, mrpB, mrpC, mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2870814..2870818 /Source="Nicolas_upshift_promotors" /id="U2465" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.868131868131868" /psig="0.999000999001" /xcortree=2700 /SigmaFactorBS="atccattacagcagttcgaagCGTGGcagcttgcagaaaagT GCGATATAATTTGGACTAGgtcgtttgaccgtatattttatacatagcgcatttttca a" /listShort="S1211, mrpA, mrpB, mrpC, mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2870834..2870853 /Source="Nicolas_upshift_promotors" /id="U2465" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.868131868131868" /psig="0.999000999001" /xcortree=2700 /SigmaFactorBS="atccattacagcagttcgaagCGTGGcagcttgcagaaaagT GCGATATAATTTGGACTAGgtcgtttgaccgtatattttatacatagcgcatttttca a" /listShort="S1211, mrpA, mrpB, mrpC, mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2870853..2871002 /Source="Nicolas_S_feature" /locus_tag="new_3246529_3246678" /HighExp="G135, G180, Diami, G150, H2O2, Oxctl, LBGexp, Paraq, Salt, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1211" upshifts 2870853 /Source="Nicolas_upshifts" /id="U2465" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.868131868131868" /psig="0.999000999001" /xcortree=2700 /SigmaFactorBS="atccattacagcagttcgaagCGTGGcagcttgcagaaaagT GCGATATAATTTGGACTAGgtcgtttgaccgtatattttatacatagcgcatttttca a" /listShort="S1211, mrpA, mrpB, mrpC, mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="upshifts" CDS 2870922..2873327 /gene="mrpA" /locus_tag="BSU_31600" /old_locus_tag="BSU31600" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 17693497, 21236240, 24095649, 24139955, 27391676" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 17693497, 21236240, 24095649, 24139955, 27391676; Product type t : transporter" /codon_start=1 /transl_table=11 /product="sodium transporter component of a Na+/H+ antiporter" /protein_id="NP_391038.2" /db_xref="EnsemblGenomes-Gn:BSU31600" /db_xref="EnsemblGenomes-Tr:CAB15149" /db_xref="GOA:Q9K2S2" /db_xref="InterPro:IPR001516" /db_xref="InterPro:IPR001750" /db_xref="InterPro:IPR005663" /db_xref="InterPro:IPR018393" /db_xref="InterPro:IPR025383" /db_xref="SubtiList:BG12355" /db_xref="UniProtKB/Swiss-Prot:Q9K2S2" /translation="MQLLHLAILSPFLFAFIIPFLAKYAKRVHTGWFVLILPVLLFIY FLPMIRMTQSGETLRSVLEWIPSLGINFTVYIDGLGLLFALLITGIGSLVTLYSIFYL SKEKEQLGPFYVYLLMFMGAMLGVVLVDNVMVLYMFWELTSLSSFLLIGYWYKREKSR YGAAKSLLITVSGGLCMLGGFILLYLITDSFSIREMVHQVQLIAGHELFIPAMILILL GAFTKSAQFPFYIWLPDAMEAPTPVSAYLHSATMVKAGIYVIARFSPIFAFSAQWFWI VSLVGLFTMVWGSFHAVKQTDLKSILAFSTVSQLGMIISMLGVSAAALHYGHTEYYTV AAMAAIFHLINHATFKGSLFMAVGIIDHETGTRDIRKLGGLMAIMPITFTISLIGTFS MAGLPPFNGFLSKEMFFTSMLRVTHFDLFNVQTWGVLFPLFAWIGSVFTFIYSMKLLF KTFRGNYQPEQLEKQAHEAPVGMLVPPVILVALAVSLFFFPNILSYSLIEPAMNSIYP TLLDGHEKFHVHISQWHGVTTELLMTAGIVVIGTIGYLSLNKWKGIYKLFPSKLTLNR LYDKLLTMMEKGSYRVTKQYMTGFLRDYLLYIFAGFIILIGGAFAIKGGFSFKTEGMA KIGVYEIILTLVMISATVATVFARSRLTAIIALGVVGYTLALFFVIFRAPDLALTQLV IETISVALFLLCFYHLPKLRLKTKTRTFRMTNFIISLGVGVIVTLLGIASSSQRTKDS IASFFVKHSHDLGGGDNVVNVILVDFRGFDTMFEITVLTIAALGIYSMIKTKVKEEGK SGE*" /label="mrpA CDS" gene 2870922..2873327 /gene="mrpA" /locus_tag="BSU_31600" /old_locus_tag="BSU31600" /label="mrpA gene" CDS 2873320..2873751 /gene="mrpB" /locus_tag="BSU_31610" /old_locus_tag="BSU31610" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 17693497, 19389778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 17693497, 19389778; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Na+/H+ antiporter complex" /protein_id="NP_391039.1" /db_xref="EnsemblGenomes-Gn:BSU31610" /db_xref="EnsemblGenomes-Tr:CAB15150" /db_xref="GOA:O05259" /db_xref="InterPro:IPR005281" /db_xref="InterPro:IPR007182" /db_xref="SubtiList:BG12356" /db_xref="UniProtKB/Swiss-Prot:O05259" /translation="MNEQKTNDLILQTATKLVSFIILLFSFYLFLSGHNAPGGGFVGG LITSSSIVLLLLAYDLKTVRSLLPVNFIYVAGAGLLLAVLTGVGSFVFGAPFLTHTFG YFQLPILGKTELATATIFDLGVYLVVVGITMTIIQTIGEEE*" /label="mrpB CDS" gene 2873320..2873751 /gene="mrpB" /locus_tag="BSU_31610" /old_locus_tag="BSU31610" /label="mrpB gene" CDS 2873751..2874092 /gene="mrpC" /locus_tag="BSU_31620" /old_locus_tag="BSU31620" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 17693497, 24021651" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 17693497, 24021651; Product type t: transporter" /codon_start=1 /transl_table=11 /product="component of Na+/H+ antiporter" /protein_id="NP_391040.2" /db_xref="EnsemblGenomes-Gn:BSU31620" /db_xref="EnsemblGenomes-Tr:CAB15151" /db_xref="GOA:O05260" /db_xref="SubtiList:BG12357" /db_xref="UniProtKB/Swiss-Prot:O05260" /translation="MEILMAVLAGIIFMAATYLLLSKSLLRVIIGTALLSHGVHLMLL TMGGLKKGAAPILSEHAKSFVDPLPQALILTAIVISFGVTSFILVMAFRAYQELKSDD MDQMRGNDQHE*" /label="mrpC CDS" gene 2873751..2874092 /gene="mrpC" /locus_tag="BSU_31620" /old_locus_tag="BSU31620" /label="mrpC gene" promotor_no_box 2873983..2874083 /Source="Nicolas_upshift_promotors" /id="U2466" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.387612387612388" /psig="0.387612387612388" /xcortree=1779 /SigmaFactorBS="tcatttcttttggcgttacgtcattcatcctcgtcatggcct ttcgcgcttatcaggaattgaaatcggacgatatggatcaaatgaggggaaatgatca a" /listShort="mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 2874043 /Source="Nicolas_upshifts" /id="U2466" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.387612387612388" /psig="0.387612387612388" /xcortree=1779 /SigmaFactorBS="tcatttcttttggcgttacgtcattcatcctcgtcatggcct ttcgcgcttatcaggaattgaaatcggacgatatggatcaaatgaggggaaatgatca a" /listShort="mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="upshifts" CDS 2874085..2875566 /gene="mrpD" /locus_tag="BSU_31630" /old_locus_tag="BSU31630" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 21236240, 24095649, 27391676" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 21236240, 24095649, 27391676; Product type t: transporter" /codon_start=1 /transl_table=11 /product="proton transporter component of Na+/H+ antiporter" /protein_id="NP_391041.3" /db_xref="EnsemblGenomes-Gn:BSU31630" /db_xref="EnsemblGenomes-Tr:CAB15152" /db_xref="GOA:O05229" /db_xref="InterPro:IPR001750" /db_xref="InterPro:IPR003918" /db_xref="InterPro:IPR004775" /db_xref="SubtiList:BG12345" /db_xref="UniProtKB/Swiss-Prot:O05229" /translation="MNNFVILPILIPLLSAILLIFMTKNLMLMRIFSTAASAIGIVIS GILVQTVFTKGIQTLSLGGWKAPYGIVLAADQFASLLVLTTAIIGLLVGLYSFRSVGE KRERSFYYSGVQFLLAGVSGAFLTGDLFNMYVFFELLLIASYMLIVLGGTKIQLRESL KYIVFNIVSSALFVIGVGFLYAVTGTLNMADLSVKISESGQTGLITVIGVLLLLVFGM KGGIFPLYFWLPGSYYAPPAAISALFGALLTKVGLYAITRVFTLIFIHDTAFTHQLMI WLAALTVIFGVIGSLAYSNVMKIVIYNIITAVGVILFGVAVHTPASIQGAIYYLIHDM LIKGALFMLAGTLIALTGTASLHKMGGLIKRYPVLGWMFFISAISLAGIPPLSGFVGK FKIAEGGFAEGEFTISMLILLSSLLVLYSVLRIFIHAFWGEEKETPKPNHRTAKGLLY PAAIFLLLSLLFGLGTEWVSPYVDQAAETLLNPEKYIEAVLKE*" /label="mrpD CDS" gene 2874085..2875566 /gene="mrpD" /locus_tag="BSU_31630" /old_locus_tag="BSU31630" /label="mrpD gene" S_feature complement(2874818..2876686) /Source="Nicolas_S_feature" /locus_tag="new_3250494_3252362_c" /HighExp="S2, Lbstat, T5.0H, T3.30H, S3, T4.0H, T3.0H, T2.30H, S1, T2.0H" /AntisenseName="mrpD" /AntisenseCor="-0.59706140653928796" /AntisenseRegPval="-26.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S1212" CDS 2875572..2876048 /gene="mrpE" /locus_tag="BSU_31640" /old_locus_tag="BSU31640" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10198001, 11004162, 15849754, 16233411, 16850406, 24142251" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10198001, 11004162, 15849754, 16233411, 16850406, 24142251; Product type t : transporter" /codon_start=1 /transl_table=11 /product="non essential component of Na+/H+ antiporter" /protein_id="YP_054591.2" /db_xref="EnsemblGenomes-Gn:BSU31640" /db_xref="EnsemblGenomes-Tr:CAE01465" /db_xref="GOA:Q7WY60" /db_xref="InterPro:IPR002758" /db_xref="SubtiList:BG14181" /db_xref="UniProtKB/Swiss-Prot:Q7WY60" /translation="MAFQILLNVFLAFCWMFLSNSPSAAGFITGYILGMLSLFFFRRF FTRQFYLWKLISIIKLCFIFIKELYLANVSVMKSVLSPKLNIRPGIFAFKTELTKDWE ITMLSLLITLTPGTLVMDISDDRTILYIHAMDIEDAEKAIFDIRESFEKAIQEVSR*" /label="mrpE CDS" gene 2875572..2876048 /gene="mrpE" /locus_tag="BSU_31640" /old_locus_tag="BSU31640" /label="mrpE gene" CDS 2876048..2876332 /gene="mrpF" /locus_tag="BSU_31650" /old_locus_tag="BSU31650" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10198001, 11004162, 11356194, 12682299, 15019740, 24142251" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10198001, 11004162, 11356194, 12682299, 15019740, 24142251; Product type t : transporter" /codon_start=1 /transl_table=11 /product="efflux transporter for Na+ and cholate" /protein_id="NP_391043.2" /db_xref="EnsemblGenomes-Gn:BSU31650" /db_xref="EnsemblGenomes-Tr:CAB15153" /db_xref="GOA:O05228" /db_xref="InterPro:IPR007208" /db_xref="SubtiList:BG12344" /db_xref="UniProtKB/Swiss-Prot:O05228" /translation="MFTLILQIALGIMAVSTFLYVIRVIKGPTVPDRVVALDAIGINL IAITALVSILLKTSAFLDIILLLGILSFIGTIAFSKFLEKGEIIENDRNR*" /label="mrpF CDS" gene 2876048..2876332 /gene="mrpF" /locus_tag="BSU_31650" /old_locus_tag="BSU31650" /label="mrpF gene" CDS 2876316..2876690 /gene="mrpG" /locus_tag="BSU_31660" /old_locus_tag="BSU31660" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11004162, 11356194, 15019740, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11004162, 11356194, 15019740, 15849754, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="non essential component of Na+/H+ antiporter" /protein_id="NP_391044.1" /db_xref="EnsemblGenomes-Gn:BSU31660" /db_xref="EnsemblGenomes-Tr:CAB15154" /db_xref="GOA:O05227" /db_xref="InterPro:IPR005133" /db_xref="SubtiList:BG12343" /db_xref="UniProtKB/Swiss-Prot:O05227" /translation="MIETAKVVVAVFILLGALICLIASFGVLRLPDVFTRAHAASKGS TLGVNMILLGVFFYLWFVTGELSAKILLGILFIFITSPIGGHLICRAAYNSGVKLDER SVQDDYNGIRNFVIKRKEDSYL*" /label="mrpG CDS" gene 2876316..2876690 /gene="mrpG" /locus_tag="BSU_31660" /old_locus_tag="BSU31660" /label="mrpG gene" downshifts 2876661 /Source="Nicolas_upshifts" /id="D1637" /incds=0 /nref=86 /ntot=185 /MaxReadThrough="1.46493" /MaxDrop="6.023" /score="32.1865197" /energy="-12.7" /TU="NA" /idTUdmin="U2464" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2876729..2877109) /gene="yuxO" /locus_tag="BSU_31670" /old_locus_tag="BSU31670" /EC_number="3.1.-.-" /function="18.1: Enzymes of unknown specificity" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 25010423; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative proofreading thioesterase in bacillibactin biosynthesis" /protein_id="NP_391045.2" /db_xref="EnsemblGenomes-Gn:BSU31670" /db_xref="EnsemblGenomes-Tr:CAB15155" /db_xref="GOA:P14205" /db_xref="InterPro:IPR003736" /db_xref="InterPro:IPR006683" /db_xref="InterPro:IPR029069" /db_xref="SubtiList:BG10382" /db_xref="UniProtKB/Swiss-Prot:P14205" /translation="MDMKHTLLEALGIEIVENTAERCVAVMPVDHRTVQPFGYLHGGA SVALAETAASAGAQNLIDHTTQACVGLEINANHLKSVKEGTVKAIAEPVHIGRTTIVY HIHIYDEQERLICISRCTLAVIKK*" /label="yuxO CDS" gene complement(2876729..2877109) /gene="yuxO" /locus_tag="BSU_31670" /old_locus_tag="BSU31670" /label="yuxO gene" downshifts complement(2876731) /Source="Nicolas_upshifts" /id="D1638" /incds=0 /nref=41 /ntot=206 /MaxReadThrough="4.53972" /MaxDrop="3.98532" /score="-4.4938943" /energy="-12.7" /TU="U2469" /idTUdmin="U2469" /TUdmin="-1050" /isTUend="FALSE" /label="downshifts" CDS complement(2877128..2877772) /gene="comA" /locus_tag="BSU_31680" /old_locus_tag="BSU31680" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10972833, 11179649, 11717295, 12950917, 16816200, 17827323, 26582911" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10972833, 11179649, 11717295, 12950917, 16816200, 17827323, 26582911; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response quorum-sensing regulator" /protein_id="NP_391046.1" /db_xref="EnsemblGenomes-Gn:BSU31680" /db_xref="EnsemblGenomes-Tr:CAB15156" /db_xref="GOA:P14204" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="PDB:2KRF" /db_xref="PDB:3ULQ" /db_xref="SubtiList:BG10381" /db_xref="UniProtKB/Swiss-Prot:P14204" /translation="MKKILVIDDHPAVMEGTKTILETDSNLSVDCLSPEPSEQFIKQH DFSSYDLILMDLNLGGEVNGMELSKQILQENPHCKIIVYTGYEVEDYFEEAIRAGLHG AISKTESKEKITQYIYHVLNGEILVDFAYFKQLMTQQKTKPAPSSQKEQDVLTPRECL ILQEVEKGFTNQEIADALHLSKRSIEYSLTSIFNKLNVGSRTEAVLIAKSDGVL*" /label="comA CDS" gene complement(2877128..2877772) /gene="comA" /locus_tag="BSU_31680" /old_locus_tag="BSU31680" /label="comA gene" S_feature complement(2877773..2877852) /Source="Nicolas_S_feature" /locus_tag="new_3253449_3253528_c" /HighExp="S2, Lbstat, M0t90, M40t90, MG 5, S1, ferm, T1.30H, nit, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S1213" CDS complement(2877853..2880162) /gene="comP" /locus_tag="BSU_31690" /old_locus_tag="BSU31690" /EC_number="2.7.-.-" /function="16.12: Sense" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 7698645, 7855425, 10419951, 14679219, 15066026, 16091050, 16787201, 20208433, 24130811; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase" /protein_id="NP_391047.2" /db_xref="EnsemblGenomes-Gn:BSU31690" /db_xref="EnsemblGenomes-Tr:CAB15157" /db_xref="GOA:Q99027" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10380" /db_xref="UniProtKB/Swiss-Prot:Q99027" /translation="MKNLIKKFTIAVIVLSILYISYTTYISMNGIIIGTKIHKNDKSQ FMIEEISESSYGQFVGLRQGDIILKINKEKPSDKHLKWGYLSHINSLDILRSGKKIHL KDFDLVTLNRPYSFFLFVLPLFFYFLSIICIFYILKVNKKRRSFAAYILILLLLDISI AYISAGGPFRGHIINRYINLFTFISSPILYLQFIQRYLGEIGKTFLNRISFLYIIPIF NLGIEFFQDYLQVDIDFLATLNLVSFATLTLFSFSAIYLHLNKYKYAEHSFILKLLIL TNTLSFAPFLIFFVLPIIFTGNYIFPALASASLLVLIPFGLVYQFVANKMFDIEFILG RMRYYALLAMIPTLLIVGALVLFDVMDIQMNPVRQTVFFFVVMFAVFYFKEVMDFKFR LKRFSEKFNYQDSIFKYTQLMRGVTSLQQVFKELKNTILDVLLVSKAYTFEVTPDHKV IFLDKHEVGPDWNFYQEEFENVTSEIGKIIEVNQGFLMKVGERGGSSYVLLCLSNINT PRLTRDEISWLKTLSFYTSVSMENVLHIEELMEHLKDLKQEGTNPIWLKKLMFAIEEK QRSGLARDLHDSVLQDLISLKRQCELFLGDFKKDDNPCREEVQDKLVQMNEQMSDVIS MTRETCHELRPQLLYDLGLVKALSKLVAQQQERVPFHIRLNTGRFTASLDLDSQLNLY RIIQEFLSNAVKHSQATDVLIMLISIQNKIVLHYEDDGVGFDQEKNTEHSMSMGLSGI KERVRALDGRLRIETSEGKGFKADIEIEL*" /label="comP CDS" gene complement(2877853..2880162) /gene="comP" /locus_tag="BSU_31690" /old_locus_tag="BSU31690" /label="comP gene" promotor_-35 2878847..2878854 /Source="Nicolas_upshift_promotors" /id="U2467" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.783216783216783" /psig="0.998001998001998" /xcortree=1977 /SigmaFactorBS="tcaggagtaacctcaaaggtataaGCTTTGCTtacaagcaaa acaTCCAGTATAGTATTTTTCAGttctttaaaaacttgttgaagagaagttacacccc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2878868..2878887 /Source="Nicolas_upshift_promotors" /id="U2467" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.783216783216783" /psig="0.998001998001998" /xcortree=1977 /SigmaFactorBS="tcaggagtaacctcaaaggtataaGCTTTGCTtacaagcaaa acaTCCAGTATAGTATTTTTCAGttctttaaaaacttgttgaagagaagttacacccc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2878883 /Source="Nicolas_upshifts" /id="U2467" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.783216783216783" /psig="0.998001998001998" /xcortree=1977 /SigmaFactorBS="tcaggagtaacctcaaaggtataaGCTTTGCTtacaagcaaa acaTCCAGTATAGTATTTTTCAGttctttaaaaacttgttgaagagaagttacacccc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature 2879756..2880727 /Source="Nicolas_S_feature" /locus_tag="new_3255432_3256404" /HighExp="S8, C30, S7, Gly, Lbstat, Fru, C90, Pyr, G135, M/G" /AntisenseName="comX" /AntisenseCor="-2.6572990440080099E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.606" /TUlongSig="NA" /TUlongPSig="NA" /label="S1214" upshifts 2879756 /Source="Nicolas_upshifts" /id="U2468" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.281718281718282" /psig="0.606393606393606" /xcortree=660 /SigmaFactorBS="aataacaatagaataagaatataggcagcaaatgatctcctt tttttatttactttaagtatataaaaaataCATATTATGCTTAAAAAataaaaaaaca a" /listShort="S1214" /GFF_Attribute="listLong" /label="upshifts" misc_feature 2879768..2879784 /Source="Nicolas_upshift_promotors" /id="U2468" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.281718281718282" /psig="0.606393606393606" /xcortree=660 /SigmaFactorBS="aataacaatagaataagaatataggcagcaaatgatctcctt tttttatttactttaagtatataaaaaataCATATTATGCTTAAAAAataaaaaaaca a" /listShort="S1214" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(2880177..2880344) /gene="comX" /locus_tag="BSU_31700" /old_locus_tag="BSU31700" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11751817, 12067344, 14679219, 16407988, 17240141, 18323630, 21636272, 21821957, 28326143, 28391484" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11751817, 12067344, 14679219, 16407988, 17240141, 18323630, 21636272, 21821957, 28326143, 28391484; Product type f: factor" /codon_start=1 /transl_table=11 /product="competence pheromone precursor (pheromone peptide aa 46->55, geranyl-modified)" /protein_id="NP_391048.1" /db_xref="EnsemblGenomes-Gn:BSU31700" /db_xref="EnsemblGenomes-Tr:CAB15158" /db_xref="GOA:P45453" /db_xref="InterPro:IPR009233" /db_xref="SubtiList:BG11324" /db_xref="UniProtKB/Swiss-Prot:P45453" /translation="MQDLINYFLNYPEALKKLKNKEACLIGFDVQETETIIKAYNDYY LADPITRQWGD*" /label="comX CDS" gene complement(2880177..2880344) /gene="comX" /locus_tag="BSU_31700" /old_locus_tag="BSU31700" /label="comX gene" CDS complement(2880332..2881230) /gene="comQ" /locus_tag="BSU_31710" /old_locus_tag="BSU31710" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11751817, 12067344, 14679219, 16407988, 16452308, 17240141, 22878193, 24425772, 25036949" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11751817, 12067344, 14679219, 16407988, 16452308, 17240141, 22878193, 24425772, 25036949; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isoprenyl transferase (pre-ComX modification)" /protein_id="NP_391049.2" /db_xref="EnsemblGenomes-Gn:BSU31710" /db_xref="EnsemblGenomes-Tr:CAB15159" /db_xref="GOA:P33690" /db_xref="InterPro:IPR000092" /db_xref="InterPro:IPR008949" /db_xref="InterPro:IPR033965" /db_xref="SubtiList:BG10379" /db_xref="UniProtKB/Swiss-Prot:P33690" /translation="MKEIVEQNIFNEDLSQLLYSFIDSKETFSFAESTILHYVVFGGE NLDVATRLGAGIEILILSSDIMDDLEDEDNHHALWMKINRSESLNAALSLYTVGLTSI YSLNNNPLIFKYVLKYVNEAMQGQHDDITNKSKTEDESLEVIRLKCGSLIALANVAGV LLATGEYNETVERYSYYKGIIAQISGDYYVLLSGNRSDIEKNKHTLIYLYLKRLFNDA SEDLLYLISHKDLYYKSLLDKEKFQEKLIKAGVTQYISVLLEIYKQKCISAIEQLNLD KEKKS**RNAY*VIQRGIQDARP" /label="comQ CDS" gene complement(2880332..2881230) /gene="comQ" /locus_tag="BSU_31710" /old_locus_tag="BSU31710" /label="comQ gene" S_feature complement(2881231..2881344) /Source="Nicolas_S_feature" /locus_tag="new_3256908_3257021_c" /HighExp="M9-stat, T1.30H, T0.30H, T1.0H, S4, T2.30H, M0t90, S5, M40t90, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S1215" promotor_-10 complement(2881338..2881357) /Source="Nicolas_upshift_promotors" /id="U2469" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.376623376623377" /psig="0.987012987012987" /xcortree=3084 /SigmaFactorBS="gaaacaagtcttttttttcgttctaccGATACAAtaaatgga taaagTATTATATGATTGTTAAAAAacgaaaaacctgctgtcctttaaatgtcccatt t" /listShort="S1215, comQ, comX, comP, S1213, comA, yuxO, S1212" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2881344) /Source="Nicolas_upshifts" /id="U2469" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.376623376623377" /psig="0.987012987012987" /xcortree=3084 /SigmaFactorBS="gaaacaagtcttttttttcgttctaccGATACAAtaaatgga taaagTATTATATGATTGTTAAAAAacgaaaaacctgctgtcctttaaatgtcccatt t" /listShort="S1215, comQ, comX, comP, S1213, comA, yuxO, S1212" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2881371..2881377) /Source="Nicolas_upshift_promotors" /id="U2469" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.376623376623377" /psig="0.987012987012987" /xcortree=3084 /SigmaFactorBS="gaaacaagtcttttttttcgttctaccGATACAAtaaatgga taaagTATTATATGATTGTTAAAAAacgaaaaacctgctgtcctttaaatgtcccatt t" /listShort="S1215, comQ, comX, comP, S1213, comA, yuxO, S1212" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2881415..2881555) /gene="degQ" /locus_tag="BSU_31720" /old_locus_tag="BSU31720" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1901055, 16251307, 16942812, 17827323, 21965392, 26302846, 27920766" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1901055, 16251307, 16942812, 17827323, 21965392, 26302846, 27920766; Product type r: regulator" /codon_start=1 /transl_table=11 /product="pleiotropic regulator" /protein_id="NP_391050.1" /db_xref="EnsemblGenomes-Gn:BSU31720" /db_xref="EnsemblGenomes-Tr:CAB15160" /db_xref="GOA:Q99039" /db_xref="InterPro:IPR012554" /db_xref="SubtiList:BG10378" /db_xref="UniProtKB/Swiss-Prot:Q99039" /translation="MEKKLEEVKQLLFRLELDIKETTDSLRNINKSIDQLDKYNYAMK IS*" /label="degQ CDS" gene complement(2881415..2881555) /gene="degQ" /locus_tag="BSU_31720" /old_locus_tag="BSU31720" /label="degQ gene" downshifts complement(2881444) /Source="Nicolas_upshifts" /id="D1639" /incds=0 /nref=2 /ntot=28 /MaxReadThrough="2.48672" /MaxDrop="4.10905" /score="21.4973657" /energy="-6.5" /TU="NA" /idTUdmin="U2470" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2881556..2881642) /Source="Nicolas_S_feature" /locus_tag="new_3257233_3257319_c" /HighExp="S2, S4, BC, M9-stat, S5, S3, S6, BT, S8, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.843" /TUlongSig="NA" /TUlongPSig="NA" /label="S1216" promotor_-10 complement(2881626..2881645) /Source="Nicolas_upshift_promotors" /id="U2470" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.38961038961039" /psig="0.843156843156843" /xcortree=464 /SigmaFactorBS="atttgcggtgtcacgcaggacttttttgcatacttttCGGTG AAaaatgagccgaaaGCAGACACACTATTAGTAACagatcaaatacctaggactcgtt c" /listShort="S1216, degQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2881642) /Source="Nicolas_upshifts" /id="U2470" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.38961038961039" /psig="0.843156843156843" /xcortree=464 /SigmaFactorBS="atttgcggtgtcacgcaggacttttttgcatacttttCGGTG AAaaatgagccgaaaGCAGACACACTATTAGTAACagatcaaatacctaggactcgtt c" /listShort="S1216, degQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2881659..2881665) /Source="Nicolas_upshift_promotors" /id="U2470" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.38961038961039" /psig="0.843156843156843" /xcortree=464 /SigmaFactorBS="atttgcggtgtcacgcaggacttttttgcatacttttCGGTG AAaaatgagccgaaaGCAGACACACTATTAGTAACagatcaaatacctaggactcgtt c" /listShort="S1216, degQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2881742..2881760) /Source="Nicolas_upshift_promotors" /id="U2471" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.521478521478521" /psig="0.521478521478521" /xcortree=1454 /SigmaFactorBS="atcaaggagattaagaatctttctcaatttcAGCACATataa acgctctttcGCATAGAAAGATAGTCCCGttcttgttgtgattcctttgagtataagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2881752) /Source="Nicolas_upshifts" /id="U2471" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.521478521478521" /psig="0.521478521478521" /xcortree=1454 /SigmaFactorBS="atcaaggagattaagaatctttctcaatttcAGCACATataa acgctctttcGCATAGAAAGATAGTCCCGttcttgttgtgattcctttgagtataagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2881775..2881781) /Source="Nicolas_upshift_promotors" /id="U2471" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.521478521478521" /psig="0.521478521478521" /xcortree=1454 /SigmaFactorBS="atcaaggagattaagaatctttctcaatttcAGCACATataa acgctctttcGCATAGAAAGATAGTCCCGttcttgttgtgattcctttgagtataagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2881777..2881902 /locus_tag="BSU_31725" /old_locus_tag="BSU31725" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514001.1" /translation="MLKLRKILNLLDFNGFRIFTKQDYSPSYRIFKIEYAILGVS*" /label="hypothetical protein CDS" gene 2881777..2881902 /locus_tag="BSU_31725" /old_locus_tag="BSU31725" /label="gene" S_feature complement(2881930..2882359) /Source="Nicolas_S_feature" /locus_tag="new_3257607_3258036_c" /HighExp="LBGtran, G135, C90, Lbtran, Mt0, Lbexp, G150, G180, M40t45, C30" /AntisenseName="yuzC" /AntisenseCor="-0.77553193168722701" /AntisenseRegPval="-54.5" /CDS_PredictionProba="0.143959" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1217" promotor_-35 2881955..2881960 /Source="Nicolas_upshift_promotors" /id="U2472" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1158 /SigmaFactorBS="aaaagaccgcaacgctaaagttgtggccttttcgctttGTCA TAttcggcaattagggATCTATACATATAGAAACAtccttttttgcgaggtgctccca t" /listShort="yuzC, S1218" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2881972) /Source="Nicolas_upshifts" /id="D1640" /incds=0 /nref=23 /ntot=170 /MaxReadThrough="2.53578" /MaxDrop="3.52021" /score="21.4973657" /energy="-6.5" /TU="NA" /idTUdmin="U2473" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 2881975..2881993 /Source="Nicolas_upshift_promotors" /id="U2472" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1158 /SigmaFactorBS="aaaagaccgcaacgctaaagttgtggccttttcgctttGTCA TAttcggcaattagggATCTATACATATAGAAACAtccttttttgcgaggtgctccca t" /listShort="yuzC, S1218" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2881977 /Source="Nicolas_upshifts" /id="U2472" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1158 /SigmaFactorBS="aaaagaccgcaacgctaaagttgtggccttttcgctttGTCA TAttcggcaattagggATCTATACATATAGAAACAtccttttttgcgaggtgctccca t" /listShort="yuzC, S1218" /GFF_Attribute="listLong" /label="upshifts" CDS 2882016..2882384 /gene="cotIC" /locus_tag="BSU_31730" /old_locus_tag="BSU31730" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16321932" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16321932; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="inner spore coat protein" /protein_id="NP_391051.2" /db_xref="EnsemblGenomes-Gn:BSU31730" /db_xref="EnsemblGenomes-Tr:CAB15161" /db_xref="InterPro:IPR016559" /db_xref="SubtiList:BG14052" /db_xref="UniProtKB/Swiss-Prot:O32089" /translation="MRYRYPWFYVYPYEVRRPPAPANNIDTFIRSAKQAAGIFADAQL VLSRIAGSRELSRRILTAAEQSDKQTIRRLIKQMGVRHEVDTVFNPDGIYISLIGTQS RMILALRWSEDRNHFASIRL*" /label="cotIC CDS" gene 2882016..2882384 /gene="cotIC" /locus_tag="BSU_31730" /old_locus_tag="BSU31730" /label="cotIC gene" CDS complement(2882360..2883589) /gene="pdeH" /locus_tag="BSU_31740" /old_locus_tag="BSU31740" /EC_number="3.1.4.52" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17153922, 23893111, 28536559" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17153922, 23893111, 28536559; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cyclic di-GMP phosphodiesterase" /protein_id="NP_391052.1" /db_xref="EnsemblGenomes-Gn:BSU31740" /db_xref="EnsemblGenomes-Tr:CAB15162" /db_xref="InterPro:IPR001633" /db_xref="InterPro:IPR013976" /db_xref="InterPro:IPR014408" /db_xref="InterPro:IPR035919" /db_xref="SubtiList:BG10377" /db_xref="UniProtKB/Swiss-Prot:P14203" /translation="MRVFVARQPIFNRKEQVVAYELLYRESEENVYSAKDGDQATTDL VINSFLNIGIEKLTEGKRCFVNFTESLMFSNLPTSFNPKQLVIEILEDIPITPALISR CKELKKMGYMLALDDFYAINPQDEDLLEKLMSYIDILKIDFLKTTRMERRTILQTYGC RGLIFLAEKVETRKEYKQAVQDGFQLFQGYFFSEPRIISGHDLSTHFYSYYELLNELS KEQPNIKRVTEYIERDLSLSYQILKFLNSSHSRLSQKIESIQQAIMLLGFNEIKRWIY ILSFKDLSRKGHSSKHEIIKISLIRAKLCELLARKTSRPQPASYMLIGMFSLIDTLLH REIEEIVQELPLKDEVGQALLGHQNDYYQMLELVKLIESNNWDTCSELGNQLDKEEAY ECYLEALEWCHNLMDAK*" /label="pdeH CDS" gene complement(2882360..2883589) /gene="pdeH" /locus_tag="BSU_31740" /old_locus_tag="BSU31740" /label="pdeH gene" S_feature 2882385..2883698 /Source="Nicolas_S_feature" /locus_tag="new_3258062_3259375" /HighExp="S4, S5, S3, S6, LoTm, S8, S7, T5.0H, B36, Pyr" /AntisenseName="yuxH" /AntisenseCor="-0.78363066752642896" /AntisenseRegPval="-56.4" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1218" promotor_-10 complement(2883624..2883643) /Source="Nicolas_upshift_promotors" /id="U2473" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.795204795204795" /psig="0.999000999001" /xcortree=2206 /SigmaFactorBS="cgaagggccagttttctttatgtatatattatttttcaTGTT TAGAcaattttcgtcaaaTTATTTGATATACTTAGGGGtgaaagccgcgcgtattgta a" /listShort="yuxH, S1217" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2883643) /Source="Nicolas_upshifts" /id="U2473" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.795204795204795" /psig="0.999000999001" /xcortree=2206 /SigmaFactorBS="cgaagggccagttttctttatgtatatattatttttcaTGTT TAGAcaattttcgtcaaaTTATTTGATATACTTAGGGGtgaaagccgcgcgtattgta a" /listShort="yuxH, S1217" /GFF_Attribute="listLong" /label="upshifts" downshifts 2883656 /Source="Nicolas_upshifts" /id="D1641" /incds=0 /nref=6 /ntot=30 /MaxReadThrough="1.76106" /MaxDrop="4.58543" /score="22.3133759" /energy="-13.3" /TU="NA" /idTUdmin="U2472" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 complement(2883658..2883665) /Source="Nicolas_upshift_promotors" /id="U2473" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.795204795204795" /psig="0.999000999001" /xcortree=2206 /SigmaFactorBS="cgaagggccagttttctttatgtatatattatttttcaTGTT TAGAcaattttcgtcaaaTTATTTGATATACTTAGGGGtgaaagccgcgcgtattgta a" /listShort="yuxH, S1217" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2883726..2885198) /gene="pncB" /locus_tag="BSU_31750" /old_locus_tag="BSU31750" /EC_number="6.3.4.21" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 4296374, 12682299, 16199587, 24564896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nicotinate phosphoribosyltransferase" /protein_id="NP_391053.1" /db_xref="EnsemblGenomes-Gn:BSU31750" /db_xref="EnsemblGenomes-Tr:CAB15163" /db_xref="GOA:O32090" /db_xref="InterPro:IPR006405" /db_xref="InterPro:IPR007229" /db_xref="InterPro:IPR036068" /db_xref="SubtiList:BG13966" /db_xref="UniProtKB/Swiss-Prot:O32090" /translation="MLEYGFKDDSLSLHTDLYQINMAETYWRDGIHEKKAIFELFFRR LPFENGYAVFAGLEKAIEYLENFKFTDSDLSYLQDELGYHEDFIEYLRGLSFTGSLYS MKEGELVFNNEPIMRVEAPLVEAQLIETALLNIVNYQTLIATKAARIKGVIGDEVALE FGTRRAHEMDAAMWGARAALIGGFSATSNVRAGKRFNIPVSGTHAHALVQAYRDEYTA FKKYAETHKDCVFLVDTYDTLRSGMPNAIRVAKEFGDRINFIGIRLDSGDLAYLSKKA RKMLDEAGFTDAKVIASSDLDEHTIMNLKAQGARIDVWGVGTKLITAYDQPALGAVYK LVAIEEDGKMVDTIKISSNPEKVTTPGRKKVYRIINQSNHHSEGDYIALYDEQVNDQK RLRMFHPVHTFISKFVTNFYAKDLHELIFEKGILCYQNPEISDIQQYVQDNLSLLWEE YKRISKPEEYPVDLSEDCWSNKMQRIHEVKSRIEEELEEE*" /label="pncB CDS" gene complement(2883726..2885198) /gene="pncB" /locus_tag="BSU_31750" /old_locus_tag="BSU31750" /label="pncB gene" downshifts complement(2883736) /Source="Nicolas_upshifts" /id="D1642" /incds=0 /nref=200 /ntot=267 /MaxReadThrough="4.08676" /MaxDrop="6.72747" /score="16.2382739" /energy="-14.5" /TU="NA" /idTUdmin="U2475" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" misc_feature 2885079..2885083 /Source="Nicolas_upshift_promotors" /id="U2474" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.992007992007992" /psig="0.000999000999001" /xcortree=45 /SigmaFactorBS="tccaagcccgcaaatacggcatagccattttcaaacggaagc cttctgaaaaaCAGCTcaaaaatcgctttcttttcatgaatgccgtctctccagtacg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2885086 /Source="Nicolas_upshifts" /id="U2474" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.992007992007992" /psig="0.000999000999001" /xcortree=45 /SigmaFactorBS="tccaagcccgcaaatacggcatagccattttcaaacggaagc cttctgaaaaaCAGCTcaaaaatcgctttcttttcatgaatgccgtctctccagtacg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2885196 /Source="Nicolas_upshifts" /id="D1643" /incds=0 /nref=1 /ntot=123 /MaxReadThrough="1.2059" /MaxDrop="3.08208" /score="22.3133759" /energy="-13.3" /TU="NA" /idTUdmin="U2472" /TUdmin=1540 /isTUend="FALSE" /label="downshifts" CDS complement(2885214..2885765) /gene="pncA" /locus_tag="BSU_31760" /old_locus_tag="BSU31760" /EC_number="3.5.1.19" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15135535, 17382284, 18616465, 24340054, 24512664; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nicotinamidase; NAD salvage pathway" /protein_id="NP_391054.1" /db_xref="EnsemblGenomes-Gn:BSU31760" /db_xref="EnsemblGenomes-Tr:CAB15164" /db_xref="GOA:O32091" /db_xref="InterPro:IPR000868" /db_xref="InterPro:IPR036380" /db_xref="SubtiList:BG13965" /db_xref="UniProtKB/Swiss-Prot:O32091" /translation="MKKALICIDYTNDFVASDGKLTCGEPGRMIEEAIVNLTKEFITN GDYVVLAVDSHDEGDQYHPETRLFPPHNIKGTEGKDLYGKLLPLYQKHEHEPNVYYME KTRYSAFAGTDLELKLRERQIGELHLAGVCTDICVLHTAVDAYNKGFRIVVHKQAVAS FNQEGHAWALSHFANSIGAQVAE*" /label="pncA CDS" gene complement(2885214..2885765) /gene="pncA" /locus_tag="BSU_31760" /old_locus_tag="BSU31760" /label="pncA gene" promotor_-10 complement(2885787..2885806) /Source="Nicolas_upshift_promotors" /id="U2475" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.668331668331668" /psig=1 /xcortree=2232 /SigmaFactorBS="agacaaacggaccgtttgtctttttgttcatggcAATTCACT tacaactggagaTAAGATATAATGTTCTCATActgatggcggggaggccggctatgaa a" /listShort="pncA, pncB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2885800) /Source="Nicolas_upshifts" /id="U2475" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.668331668331668" /psig=1 /xcortree=2232 /SigmaFactorBS="agacaaacggaccgtttgtctttttgttcatggcAATTCACT tacaactggagaTAAGATATAATGTTCTCATActgatggcggggaggccggctatgaa a" /listShort="pncA, pncB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2885819..2885826) /Source="Nicolas_upshift_promotors" /id="U2475" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.668331668331668" /psig=1 /xcortree=2232 /SigmaFactorBS="agacaaacggaccgtttgtctttttgttcatggcAATTCACT tacaactggagaTAAGATATAATGTTCTCATActgatggcggggaggccggctatgaa a" /listShort="pncA, pncB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2885862..2886260) /gene="yueI" /locus_tag="BSU_31770" /old_locus_tag="BSU31770" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391055.1" /db_xref="EnsemblGenomes-Gn:BSU31770" /db_xref="EnsemblGenomes-Tr:CAB15165" /db_xref="InterPro:IPR012543" /db_xref="InterPro:IPR029064" /db_xref="PDB:2OHW" /db_xref="SubtiList:BG13964" /db_xref="UniProtKB/Swiss-Prot:O32092" /translation="MSEDKMDLYLQQGMYGPLETKPDERHLFLGSLRERVVLALTKGQ VLRSKPYKEAEHELKNSHNVTLLINGELQYQSYSSYIQMASRYGVPFKIVSDLQFHTP LGIVIAADIAVNRELIYIQDDIYNRSVLKS*" /label="yueI CDS" gene complement(2885862..2886260) /gene="yueI" /locus_tag="BSU_31770" /old_locus_tag="BSU31770" /label="yueI gene" S_feature complement(2886261..2886331) /Source="Nicolas_S_feature" /locus_tag="new_3261938_3262008_c" /HighExp="Etha, dia5, Diami, dia15, H2O2, LBGtran, LPhT, G135, G180, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="SigA" /TUlongPSig="0.998" /label="S1219" CDS complement(2886332..2886580) /gene="yueH" /locus_tag="BSU_31780" /old_locus_tag="BSU31780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391056.1" /db_xref="EnsemblGenomes-Gn:BSU31780" /db_xref="EnsemblGenomes-Tr:CAB15166" /db_xref="InterPro:IPR020260" /db_xref="SubtiList:BG13963" /db_xref="UniProtKB/Swiss-Prot:O32093" /translation="MKIRKANINTQTGMITDVYLHENRKELRTLVAVPQLEWSTIISY EEDKATLPERLEASLRRHTEETPAGELAKKIIHWVTEM*" /label="yueH CDS" gene complement(2886332..2886580) /gene="yueH" /locus_tag="BSU_31780" /old_locus_tag="BSU31780" /label="yueH gene" promotor_-10 complement(2886603..2886622) /Source="Nicolas_upshift_promotors" /id="U2476" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=1994 /SigmaFactorBS="aacagtttcgtttaacgggtaacagccttttcaCAAGaggct gttgctttttTATTGTATAATATGGGTAGTctttgaatagagaggtcatgttatgaaa a" /listShort="yueH, S1219, yueI, pncA, pncB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2886614) /Source="Nicolas_upshifts" /id="U2476" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=1994 /SigmaFactorBS="aacagtttcgtttaacgggtaacagccttttcaCAAGaggct gttgctttttTATTGTATAATATGGGTAGTctttgaatagagaggtcatgttatgaaa a" /listShort="yueH, S1219, yueI, pncA, pncB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2886638..2886641) /Source="Nicolas_upshift_promotors" /id="U2476" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=1994 /SigmaFactorBS="aacagtttcgtttaacgggtaacagccttttcaCAAGaggct gttgctttttTATTGTATAATATGGGTAGTctttgaatagagaggtcatgttatgaaa a" /listShort="yueH, S1219, yueI, pncA, pncB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2886653..2886874) /gene="yueG" /locus_tag="BSU_31790" /old_locus_tag="BSU31790" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative spore germination protein" /protein_id="NP_391057.1" /db_xref="EnsemblGenomes-Gn:BSU31790" /db_xref="EnsemblGenomes-Tr:CAB15167" /db_xref="InterPro:IPR019618" /db_xref="SubtiList:BG13962" /db_xref="UniProtKB/Swiss-Prot:O32094" /translation="MPAIVGPIYIMSVTDNAAASFGDVFAISPKSVAHSGAGSGTFQL GDFVKINNQTSKTLFKDADITDETVSFNG*" /label="yueG CDS" gene complement(2886653..2886874) /gene="yueG" /locus_tag="BSU_31790" /old_locus_tag="BSU31790" /label="yueG gene" downshifts complement(2886680) /Source="Nicolas_upshifts" /id="D1644" /incds=0 /nref=11 /ntot=31 /MaxReadThrough="3.65047" /MaxDrop="4.3681" /score="19.032155" /energy="-12.6" /TU="U2477,U2479,U2482" /idTUdmin="U2482" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" downshifts 2886868 /Source="Nicolas_upshifts" /id="D1645" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="1.17049" /MaxDrop="3.0193" /score="-7.47675224" /energy="-6.7" /TU="NA" /idTUdmin="U2480" /TUdmin="-1320" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2886892..2886911) /Source="Nicolas_upshift_promotors" /id="U2477" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1310 /SigmaFactorBS="ggaaaacgcaaagccagctgaatagGCGGGCACCAttatcgg ctcctTGCATATGATGCTGTAAATCaatgcggaggtggggaaatgcctgcaattgtgg g" /listShort="yueG, yueH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2886898) /Source="Nicolas_upshifts" /id="U2477" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1310 /SigmaFactorBS="ggaaaacgcaaagccagctgaatagGCGGGCACCAttatcgg ctcctTGCATATGATGCTGTAAATCaatgcggaggtggggaaatgcctgcaattgtgg g" /listShort="yueG, yueH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2886924..2886933) /Source="Nicolas_upshift_promotors" /id="U2477" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1310 /SigmaFactorBS="ggaaaacgcaaagccagctgaatagGCGGGCACCAttatcgg ctcctTGCATATGATGCTGTAAATCaatgcggaggtggggaaatgcctgcaattgtgg g" /listShort="yueG, yueH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2886934..2888043) /gene="yueF" /locus_tag="BSU_31800" /old_locus_tag="BSU31800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391058.1" /db_xref="EnsemblGenomes-Gn:BSU31800" /db_xref="EnsemblGenomes-Tr:CAB15168" /db_xref="GOA:O32095" /db_xref="InterPro:IPR002549" /db_xref="SubtiList:BG13961" /db_xref="UniProtKB/Swiss-Prot:O32095" /translation="MLKSKVHFWTLQILFVLLIIFVATKVSFVFQPFIVFISTLFFPM LIAGILYFIFNPVVRLLEKKIPRTLSILLIYLLFIGLLAFISASVGPIITAQVTGLFN NLPDYIKQIQALTKDLSHSQWFTWMMNQDYVSISKIEQSLTSFLQNLPQNITSSLSAV FGVVTNITLVIITVPFILFYMLKDGHRFPHLAVKILPASYRTEGLKIFKDLSDTLAAY FQGQLLICLFVGTACFIGYLIAGLPYALILGIVMAITNIIPYVGPFLGAAPAVIVGFM DSPAKALFAIIVVVIVQQLDGNLLSPLVIGKRLNTHPLTIILLLIGAGSFGGILGMIL AVPVYAVVKAFFLNIVRLIKLRQRSRLEENAKPAE*" /label="yueF CDS" gene complement(2886934..2888043) /gene="yueF" /locus_tag="BSU_31800" /old_locus_tag="BSU31800" /label="yueF gene" promotor_-35 2887695..2887702 /Source="Nicolas_upshift_promotors" /id="U2478" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2030 /SigmaFactorBS="ccaggtaaaccattgagaatgggacaaatCCTTTGTCagcgc ctgaatctgTTTTATATAATCAGGAAGGTtgttaaacagccctgtcacctgtgcggtg a" /listShort="S1220, yuzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2887717..2887736 /Source="Nicolas_upshift_promotors" /id="U2478" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2030 /SigmaFactorBS="ccaggtaaaccattgagaatgggacaaatCCTTTGTCagcgc ctgaatctgTTTTATATAATCAGGAAGGTtgttaaacagccctgtcacctgtgcggtg a" /listShort="S1220, yuzE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2887726..2888120 /Source="Nicolas_S_feature" /locus_tag="new_3263403_3263797" /HighExp="dia15, S8, H2O2, dia5, LBGstat, Paraq, C30, S7, Diami, G180" /AntisenseName="yueF" /AntisenseCor="0.28555063485711402" /AntisenseRegPval="-5.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1220" upshifts 2887726 /Source="Nicolas_upshifts" /id="U2478" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2030 /SigmaFactorBS="ccaggtaaaccattgagaatgggacaaatCCTTTGTCagcgc ctgaatctgTTTTATATAATCAGGAAGGTtgttaaacagccctgtcacctgtgcggtg a" /listShort="S1220, yuzE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2888091..2888110) /Source="Nicolas_upshift_promotors" /id="U2479" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.380619380619381" /psig="0.999000999001" /xcortree=2209 /SigmaFactorBS="cggccttcatcaccaacactcctttcattatattaagaGTTC TGatatgagttcattTTTGTTACAATGATGGGGTAtaagttcttttatctgacagaca a" /listShort="yueF, yueG, yueH, S1219, yueI" /listLong="pncA, pncB" /label="promotor_-10" upshifts complement(2888107) /Source="Nicolas_upshifts" /id="U2479" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.380619380619381" /psig="0.999000999001" /xcortree=2209 /SigmaFactorBS="cggccttcatcaccaacactcctttcattatattaagaGTTC TGatatgagttcattTTTGTTACAATGATGGGGTAtaagttcttttatctgacagaca a" /listShort="yueF, yueG, yueH, S1219, yueI" /listLong="pncA, pncB" /label="upshifts" S_feature complement(2888109..2888549) /Source="Nicolas_S_feature" /locus_tag="new_3263786_3264226_c" /HighExp="Diami, S8, H2O2, S7, C90, Paraq, Salt, S1, dia15, dia5" /AntisenseName="yuzE" /AntisenseCor="0.47136608606324898" /AntisenseRegPval="-15.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1221" promotor_-35 2888112..2888114 /Source="Nicolas_upshift_promotors" /id="U2480" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.657342657342657" /psig="0.657342657342657" /xcortree=1364 /SigmaFactorBS="tttctttgtctgtcagataaaagaacttataccccatcattg taacaaaaATGaactcatatcagaacTCTTAATATAATGAAAGGAGtgttggtgatga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2888122 /Source="Nicolas_upshifts" /id="U2480" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.657342657342657" /psig="0.657342657342657" /xcortree=1364 /SigmaFactorBS="tttctttgtctgtcagataaaagaacttataccccatcattg taacaaaaATGaactcatatcagaacTCTTAATATAATGAAAGGAGtgttggtgatga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2888124..2888129) /Source="Nicolas_upshift_promotors" /id="U2479" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.380619380619381" /psig="0.999000999001" /xcortree=2209 /SigmaFactorBS="cggccttcatcaccaacactcctttcattatattaagaGTTC TGatatgagttcattTTTGTTACAATGATGGGGTAtaagttcttttatctgacagaca a" /listShort="yueF, yueG, yueH, S1219, yueI" /listLong="pncA, pncB" /label="promotor_-35" promotor_-10 2888130..2888149 /Source="Nicolas_upshift_promotors" /id="U2480" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.657342657342657" /psig="0.657342657342657" /xcortree=1364 /SigmaFactorBS="tttctttgtctgtcagataaaagaacttataccccatcattg taacaaaaATGaactcatatcagaacTCTTAATATAATGAAAGGAGtgttggtgatga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2888158..2888547 /gene="yuzE" /locus_tag="BSU_31810" /old_locus_tag="BSU31810" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391059.1" /db_xref="EnsemblGenomes-Gn:BSU31810" /db_xref="EnsemblGenomes-Tr:CAB15169" /db_xref="InterPro:IPR016789" /db_xref="InterPro:IPR019270" /db_xref="SubtiList:BG14054" /db_xref="UniProtKB/Swiss-Prot:O32096" /translation="MKAVTYDTDSELAYIYVLPPKKNRNVRTEELRVNDCLLLDISQD GKIAGFECFGEAAHLCAPFAGKSRLYVKDSDGYHFRVCQHASVRSCYTVYRVTFCFSD GDYQEFAGFDLDGTMYHSAFLQRLTEK*" /label="yuzE CDS" gene 2888158..2888547 /gene="yuzE" /locus_tag="BSU_31810" /old_locus_tag="BSU31810" /label="yuzE gene" CDS complement(2888588..2888824) /gene="yuzF" /locus_tag="BSU_31820" /old_locus_tag="BSU31820" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391060.1" /db_xref="EnsemblGenomes-Gn:BSU31820" /db_xref="EnsemblGenomes-Tr:CAB15170" /db_xref="InterPro:IPR020139" /db_xref="SubtiList:BG14055" /db_xref="UniProtKB/Swiss-Prot:O32097" /translation="MVNQGSPQLVSLVDPYVYQTIKKLIGSRFVIQTVRDTVRGRLID VKPDHITIEGARNSVCLIRIQHMISVTPDYSERV*" /label="yuzF CDS" gene complement(2888588..2888824) /gene="yuzF" /locus_tag="BSU_31820" /old_locus_tag="BSU31820" /label="yuzF gene" downshifts complement(2888594) /Source="Nicolas_upshifts" /id="D1646" /incds=0 /nref=12 /ntot=37 /MaxReadThrough="5.19136" /MaxDrop="5.1675" /score="30.7642328" /energy="-9.9" /TU="U2482" /idTUdmin="U2481" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2888844..2888863) /Source="Nicolas_upshift_promotors" /id="U2481" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1324 /SigmaFactorBS="aatctccgcacccctttgttttatcaggtaagCCTGTGTCAT tatccataagcgcGGCATAAGCTGAGATAAAACacacaaaggggataaaagtatggtc a" /listShort="yuzF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2888858) /Source="Nicolas_upshifts" /id="U2481" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1324 /SigmaFactorBS="aatctccgcacccctttgttttatcaggtaagCCTGTGTCAT tatccataagcgcGGCATAAGCTGAGATAAAACacacaaaggggataaaagtatggtc a" /listShort="yuzF" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2888860..2889000) /Source="Nicolas_S_feature" /locus_tag="new_3264537_3264677_c" /HighExp="BT, Diami, S8, Etha, Sw, C90, Salt, B36, LPhT, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.998, 0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S1222" promotor_-35 complement(2888877..2888886) /Source="Nicolas_upshift_promotors" /id="U2481" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1324 /SigmaFactorBS="aatctccgcacccctttgttttatcaggtaagCCTGTGTCAT tatccataagcgcGGCATAAGCTGAGATAAAACacacaaaggggataaaagtatggtc a" /listShort="yuzF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2889001..2889531) /gene="yueE" /locus_tag="BSU_31830" /old_locus_tag="BSU31830" /EC_number="3.-.-.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent phosphohydrolase" /protein_id="NP_391061.1" /db_xref="EnsemblGenomes-Gn:BSU31830" /db_xref="EnsemblGenomes-Tr:CAB15171" /db_xref="GOA:O32098" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR006674" /db_xref="InterPro:IPR006675" /db_xref="SubtiList:BG13960" /db_xref="UniProtKB/Swiss-Prot:O32098" /translation="MRKVTLMDVFTHPIAQKYLQRSGVAHAIACAYHAYRLSVKADIN PDLAAKAALLHDIGHYEWYTDGKWDYEKYKRNDIHAIKGAERAHKLLIRLGEEPKAAK EIALAILLHTDSYLPEGELDKNTLQQIVKKADELDEEPGGHHHYRQIDPSTARKKIEK LDQLIDQAQASVIKPV*" /label="yueE CDS" gene complement(2889001..2889531) /gene="yueE" /locus_tag="BSU_31830" /old_locus_tag="BSU31830" /label="yueE gene" promotor_-10 complement(2889551..2889570) /Source="Nicolas_upshift_promotors" /id="U2482" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.494505494505495" /psig="0.998001998001998" /xcortree=636 /SigmaFactorBS="atgataagaagatcaaaatgatgtgacataagAATTGAGTTt ctctgcaaatTATGTTAGGATTCTAAAAATatctaaaggaggggtttccatgagaaag g" /listShort="yueE, S1222, yuzF, S1221, yueF, yueG" /listLong="yueH, S1219, yueI, pncA, pncB" /label="promotor_-10" upshifts complement(2889562) /Source="Nicolas_upshifts" /id="U2482" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.494505494505495" /psig="0.998001998001998" /xcortree=636 /SigmaFactorBS="atgataagaagatcaaaatgatgtgacataagAATTGAGTTt ctctgcaaatTATGTTAGGATTCTAAAAATatctaaaggaggggtttccatgagaaag g" /listShort="yueE, S1222, yuzF, S1221, yueF, yueG" /listLong="yueH, S1219, yueI, pncA, pncB" /label="upshifts" S_feature complement(2889564..2889650) /Source="Nicolas_S_feature" /locus_tag="new_3265241_3265327_c" /HighExp="BT, S8, S6, S7, B36, Etha, S5, S4, Pyr, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S1223" promotor_-35 complement(2889582..2889590) /Source="Nicolas_upshift_promotors" /id="U2482" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.494505494505495" /psig="0.998001998001998" /xcortree=636 /SigmaFactorBS="atgataagaagatcaaaatgatgtgacataagAATTGAGTTt ctctgcaaatTATGTTAGGATTCTAAAAATatctaaaggaggggtttccatgagaaag g" /listShort="yueE, S1222, yuzF, S1221, yueF, yueG" /listLong="yueH, S1219, yueI, pncA, pncB" /label="promotor_-35" promotor_-10 complement(2889645..2889664) /Source="Nicolas_upshift_promotors" /id="U2483" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=730 /SigmaFactorBS="tcttttttttatacaaaaggctgcaGCCAGCGCATtttattg aacagcCGCATATACTGACTGAAACGttgcttttagggtataacaatgatgataagaa g" /listShort="S1223, yueE, S1222, yuzF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2889652) /Source="Nicolas_upshifts" /id="U2483" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=730 /SigmaFactorBS="tcttttttttatacaaaaggctgcaGCCAGCGCATtttattg aacagcCGCATATACTGACTGAAACGttgcttttagggtataacaatgatgataagaa g" /listShort="S1223, yueE, S1222, yuzF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2889678..2889687) /Source="Nicolas_upshift_promotors" /id="U2483" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=730 /SigmaFactorBS="tcttttttttatacaaaaggctgcaGCCAGCGCATtttattg aacagcCGCATATACTGACTGAAACGttgcttttagggtataacaatgatgataagaa g" /listShort="S1223, yueE, S1222, yuzF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2889729..2890460) /gene="bznD" /locus_tag="BSU_31840" /old_locus_tag="BSU31840" /EC_number="1.1.1.320" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11745140, 21670841; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="benzil reductase (benzoin forming)" /protein_id="NP_391062.1" /db_xref="EnsemblGenomes-Gn:BSU31840" /db_xref="EnsemblGenomes-Tr:CAB15172" /db_xref="GOA:O32099" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13959" /db_xref="UniProtKB/Swiss-Prot:O32099" /translation="MELYIITGASKGLGQAIALQALEKGHEVHALSRTKTDVSHKKLT QHQIDLINLEEAEQQFETLLSSIDSDRYSGITLINNAGMVTPIKRAGEASLDELQRHY QLNLTAPVLLSQLFTKRFASYSGKKTVVNITSGAAKNPYKGWSAYCSSKAGLDMFTRT FGFEQEDEELPVNMISFSPGVMDTEMQAVIRSSSKKDFHHIERFRKLNETGSLRSPDF IAGTLLSLLEKGTENGRIYDIKEFL*" /label="bznD CDS" gene complement(2889729..2890460) /gene="bznD" /locus_tag="BSU_31840" /old_locus_tag="BSU31840" /label="bznD gene" downshifts complement(2889759) /Source="Nicolas_upshifts" /id="D1647" /incds=0 /nref=183 /ntot=253 /MaxReadThrough="2.76356" /MaxDrop="5.18507" /score="30.7642328" /energy="-9.9" /TU="NA" /idTUdmin="U2484" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2890475..2890494) /Source="Nicolas_upshift_promotors" /id="U2484" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.996003996003996" /psig=1 /xcortree=2058 /SigmaFactorBS="gcgcaggaaaacaagaaggcgtaggccgcgTGCTTGTGttgt gtaaaagaggTGCCGTACAATAATAACGGAaaaggaggtttccaatggaactttatat c" /listShort="yueD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2890486) /Source="Nicolas_upshifts" /id="U2484" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.996003996003996" /psig=1 /xcortree=2058 /SigmaFactorBS="gcgcaggaaaacaagaaggcgtaggccgcgTGCTTGTGttgt gtaaaagaggTGCCGTACAATAATAACGGAaaaggaggtttccaatggaactttatat c" /listShort="yueD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2890509..2890516) /Source="Nicolas_upshift_promotors" /id="U2484" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.996003996003996" /psig=1 /xcortree=2058 /SigmaFactorBS="gcgcaggaaaacaagaaggcgtaggccgcgTGCTTGTGttgt gtaaaagaggTGCCGTACAATAATAACGGAaaaggaggtttccaatggaactttatat c" /listShort="yueD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2890523..2890978) /gene="yueC" /locus_tag="BSU_31850" /old_locus_tag="BSU31850" /function="11.1: Protein and peptide secretion and trafficking" /experiment="publication(s) with functional evidences, PMID:15576783, 24798022" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15576783, 24798022; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ESX secretion system YueC protein" /protein_id="NP_391063.1" /db_xref="EnsemblGenomes-Gn:BSU31850" /db_xref="EnsemblGenomes-Tr:CAB15173" /db_xref="GOA:O32100" /db_xref="InterPro:IPR018920" /db_xref="InterPro:IPR020212" /db_xref="SubtiList:BG13958" /db_xref="UniProtKB/Swiss-Prot:O32100" /translation="MLSFSLFIPSAAAAQTEENTDVAPNQYEKKDIEIDTNYLHEDTY YEEKTELPEEQKDITFDKPKDKDAELIKDLFTSTNAEDSNTIAAQSKQLGITFAEKPM TKTSSTETEDEQETSSLLLPMIYVVLILLGIAGIVFLIPKVTAQENKKA*" /label="yueC CDS" gene complement(2890523..2890978) /gene="yueC" /locus_tag="BSU_31850" /old_locus_tag="BSU31850" /label="yueC gene" promotor_-35 2890931..2890937 /Source="Nicolas_upshift_promotors" /id="U2485" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=235 /SigmaFactorBS="actggtttggcgcgacatctgtattttcttcAGTTTGGgcag ccgctgcagaGGGTATGAAAAGGGAAAAGgagagcatacaaatcatgatccccttttc c" /listShort="S1224" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2890952..2890970 /Source="Nicolas_upshift_promotors" /id="U2485" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=235 /SigmaFactorBS="actggtttggcgcgacatctgtattttcttcAGTTTGGgcag ccgctgcagaGGGTATGAAAAGGGAAAAGgagagcatacaaatcatgatccccttttc c" /listShort="S1224" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2890960..2893327 /Source="Nicolas_S_feature" /locus_tag="new_3266637_3269004" /HighExp="Etha, Gly, Sw, Salt, LoTm, C30, BT, HiTm, Mal, G135" /AntisenseName="yueB" /AntisenseCor="-9.3455707286730305E-2" /AntisenseRegPval="-0.9" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1224" upshifts 2890960 /Source="Nicolas_upshifts" /id="U2485" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=235 /SigmaFactorBS="actggtttggcgcgacatctgtattttcttcAGTTTGGgcag ccgctgcagaGGGTATGAAAAGGGAAAAGgagagcatacaaatcatgatccccttttc c" /listShort="S1224" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2891010..2894240) /gene="yueB" /locus_tag="BSU_31860" /old_locus_tag="BSU31860" /function="11.1: Protein and peptide secretion and trafficking" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15576783, 24798022, 27179995" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15576783, 24798022, 27179995; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ESX secretion system; calcium-dependent phage SPP1 attachment site" /protein_id="NP_391064.1" /db_xref="EnsemblGenomes-Gn:BSU31860" /db_xref="EnsemblGenomes-Tr:CAB15174" /db_xref="GOA:O32101" /db_xref="InterPro:IPR023838" /db_xref="SubtiList:BG13957" /db_xref="UniProtKB/Swiss-Prot:O32101" /translation="MTEQRKSLIKLISAVIIILLLPVLFFRFIGDDPTKKAVNSTRQI AVVNEDTGVLSDEVKSDEEDKSAQFGKEVAAVLGERPDYSWTVVNRSAAETGLASKKY DAIVYIPSDFSKNILSYDKDHPQKATLEFSIQDNLNAVNKEKVQRELEDAQKTMNKKM SALYWNFVSQKVDNIRGEFDKIVNKESEFQNVMYNFYKPSSNDLAGEIKQQKDLIDEL KKSMNEAQGTTKEKASTAEEAKNTLKEFIDTVERYKEYQENQKKLLLAAQDSTQQQIR TGLDAIQAQQKANQFSERMSGLATGIGQAKTQIGLTNLALNNAEKLRQNQVPLQEMGM KKIENDMFNAFLSRYKSQYEAIKYQNLNQLQENIGKNRLSLLKPKESDEKEDGEDTSD NKDDTDKEDIEDIKLDLEKQRDELKNVATEIKDISEGLKEPEQEKPTTPDAEEPSTDD SPNTEEPSNDIPTSDDQPTNEDTGSSEEGTQDNGSQNDVQTNIETGQKHQESSKNVPE QDTNTENTGTSKTDFSLIELADENDGSNQSDGLQGDGADGETDISGAKKRLNEAAIKL EEIENALQEKQEEHNNKLEKHIDELNQEIKELNKTVSKLNDQIGDLTKKLVDFDNNVN DAYRLIYNLEDEIIQTLQSRGYIDQKEKLSSIFSSRIETDNISNLMKYYNSLNLYKST LNDNLDLGSLTIIKGEVIQEQDGNVQSVLALTPEESASWEALKNNTMQTDEDINSFID GMTKFADDYSGYIRDSQAGVLDELTKISESAAKASEQLVTGATQESATFSNDGLSGTM ALSVQDTVGQEVLQMSDMMGSLSDRQSGIIDYTTNMQQSVNDVQAKADTLNNNWGKNV ASTKLVRNDVYGILGNTLVDGQNNGYVYDYLANPLKISGEVPEEKIQTVPPVVILVIV LISSLLIGYFSSYYQNAPLLVKGALFGILNILVGLMISLFGLNIYSLPDDQTIKWSVF TILLLVASSAFIRTAFRFGSIPGWVASAAMILFYVAPLIDLIMPNFTFEDPVSKVYID IQYGTGHLFTMGITVLLIITVIAVALPLIIRLMAEHTAESDETYEA*" /label="yueB CDS" gene complement(2891010..2894240) /gene="yueB" /locus_tag="BSU_31860" /old_locus_tag="BSU31860" /label="yueB gene" CDS complement(2894237..2898724) /gene="yukAB" /locus_tag="BSU_31875" /old_locus_tag="BSU31875" /function="11.1: Protein and peptide secretion and trafficking" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15576783, 24798022" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15576783, 24798022; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ESX secretion system FtsK/SpoIIIE family ATPase" /protein_id="NP_391066.2" /db_xref="EnsemblGenomes-Gn:BSU31875" /db_xref="EnsemblGenomes-Tr:CAB15176" /db_xref="GOA:C0SPA7" /db_xref="InterPro:IPR002543" /db_xref="InterPro:IPR022206" /db_xref="InterPro:IPR023839" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12375" /db_xref="UniProtKB/Swiss-Prot:C0SPA7" /translation="MSLLWVFYQNNVQKLNLSNLPSSHPVTIGPDVKDSVTISTIPFN SGVISLKRKESGGQYEVFLGNDCLGTIETDISFTLQTDQQDIRLILTGSEPEKSVYFT GNRDEIVCSSEKTNADIYLNPQDFAFAEQSTFSLLRAGGSWSVRPESGTIFLNGEKIN ANTPLKPGDEIFWNFTQMRVTEQDLLEIVHYAQFETALTETVKPSTEMQKKYPQYRRT PRMVYDLPDDRVSFSFPSQESDQTNRGLWLVILPPLVMLIVMGVVAIIQPRGIFILVS LAMFMMTLITSTVQYFRDKNQRKKREEKRERVYKLYLDNKRKELQALAEKQKQVLEFH FPSFEQMKYLTSEISDRIWEKSLESKDYLQLRLGTGTVPSSYEINMSGGDLANRDIDD LMEKSQHMQRVYKDIRNAPVTVDLAEGPMGLVGKSQIVKNEIHQLIGQLSFFNSYHDL RFVFIFHEEEYKDWEWMKWLPQFQMPHIYAKGFIYNEQTRDQLLSSLYELIRERDLED DKEKLQFKPHFVFVITNQQLISEHVILEYLEGQHEHLGISTIVAAETKESLSENITTL VRYINEHEGDILIQKKKAVRIPFRLDHHQREDNERFSRTLRTLNHQVGITNSIPETVS FLELFHAKEVKEIGIQQRWLTSESSKSLSVPIGYKGKDDIVYLNLHEKAHGPHGLLAG TTGSGKSEFLQTYILSLAVHFHPHEAAFLLIDYKGGGMAQPFRNIPHLLGTITNIEGS KNFSMRALASIKSELKKRQRLFDQYQVNHINDYTKLYKQGKAEVAMPHLFLISDEFAE LKSEEPDFIRELVSAARIGRSLGVHLILATQKPGGIIDDQIWSNSRFKVALKVQDATD SKEILKNSDAANITVTGRGYLQVGNNEVYELFQSAWSGAPYLEEVYGTEDEIAIVTDT GLIPLSEVDTEDNAKKDVQTEIEAVVDEIERIQDEMGIEKLPSPWLPPLAERIPRTLF PSNEKDHFHFAYVDEPDLQRQAPIAYKMMEDGNIGIFGSSGYGKSIAAATFLMSFADV YTPEELHVYIFDFGNGTLLPLAKLPHTADYFLMDQSRKIEKFMIRIKEEIDRRKRLFR EKEISHIKMYNALSEEELPFIFITIDNFDIVKDEMHELESEFVQLSRDGQSLGIYFML TATRVNAVRQSLLNNLKTKIVHYLMDQSEGYSIYGRPKFNLEPIPGRVIIQKEELYFA QMFLPVDADDDIGMFNELKSDVQKLQGRFASMEQPAPIPMLPESLSTRELSIRFKLER KPLSVPIGLHEETVSPVYFDLGKHKHCLILGQTQRGKTNVLKVMLEHLIDDETEMIGL FDSIDRGLSHYAKESDVSYLETKEDIEQWIETAEDIFKTREAMYVEAVRQGDAQNLRF SQVVLMIDGITRFQQTIDTRIQDRLANFMKSYAHLGFSFIPGGNHSEFSKGYDSLTTE MKQIRHAILLMKKSEQNVIPLPYQRQEPEIQPGFGYVVENGKEQKVQIPLCSAERESA R*" /label="yukAB CDS" gene complement(2894237..2898724) /gene="yukAB" /locus_tag="BSU_31875" /old_locus_tag="BSU31875" /label="yukAB gene" promotor_-35 2897999..2898005 /Source="Nicolas_upshift_promotors" /id="U2486" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=203 /SigmaFactorBS="cggaggcaggatgacgagccacagccctctgttGGTTTGAtc gctctcctgagaGGGAAAACTGAAAGAAACGcggtcatccggcagatcgtataccatc c" /listShort="S1225" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2898020..2898038 /Source="Nicolas_upshift_promotors" /id="U2486" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=203 /SigmaFactorBS="cggaggcaggatgacgagccacagccctctgttGGTTTGAtc gctctcctgagaGGGAAAACTGAAAGAAACGcggtcatccggcagatcgtataccatc c" /listShort="S1225" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2898026..2898988 /Source="Nicolas_S_feature" /locus_tag="new_3273703_3274665" /HighExp="Etha, Sw, Gly, Salt, B60, M9-stat, LoTm, T0.30H, BT, LPhT" /AntisenseName="yukB" /AntisenseCor="-0.26212584196591598" /AntisenseRegPval="-4.9000000000000004" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1225" upshifts 2898026 /Source="Nicolas_upshifts" /id="U2486" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=203 /SigmaFactorBS="cggaggcaggatgacgagccacagccctctgttGGTTTGAtc gctctcctgagaGGGAAAACTGAAAGAAACGcggtcatccggcagatcgtataccatc c" /listShort="S1225" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2898785..2900140) /gene="yukC" /locus_tag="BSU_31890" /old_locus_tag="BSU31890" /function="11.1: Protein and peptide secretion and trafficking" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15576783, 16845009, 24798022" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15576783, 16845009, 24798022; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ESX secretion system YukC protein" /protein_id="NP_391067.1" /db_xref="EnsemblGenomes-Gn:BSU31890" /db_xref="EnsemblGenomes-Tr:CAB15177" /db_xref="GOA:P71070" /db_xref="InterPro:IPR018778" /db_xref="SubtiList:BG12376" /db_xref="UniProtKB/Swiss-Prot:P71070" /translation="MSGEQKSYLENQLEAVAEKTDAGYTFTFQREKIKLLDGLEANVI KDINPFFHKEIDVTDDEVIITIQPPSSYKAFRFMKAKDKKSKWQFAYQLVQAVQQHNL SRLNLIVAPENIVFDKGLTPYFLHYGVKESIPPYERDEERVWQELKAAAALAVDGAFA FEDYLKFNETLTFSAEAKAILDAESYDDLLELIQTHIDELEAKAKTYIHIPRKKWNIQ RYIGLGLIVLLVPALIYSMYALFFAQPKHQAIVDSNRAFLNKQYSEVISTLSKYDAES LPESVQYQLATSYVEVENLGSAKTKNIENNLVTLQSDPQHFLYWIDYGRGEYKEAISI GRKLEYNDYIYFALAKYKQQLLSEDTNDEDIQKELDSVNSELEKAQKERQENKQSNSE TSLVDTSEEQTQTDEEKQAEEKAAEEKAAAEEKAKKEEQKEKEDEKKETEKKDEKKDD K*" /label="yukC CDS" gene complement(2898785..2900140) /gene="yukC" /locus_tag="BSU_31890" /old_locus_tag="BSU31890" /label="yukC gene" downshifts complement(2898806) /Source="Nicolas_upshifts" /id="D1648" /incds=0 /nref=5 /ntot=116 /MaxReadThrough="6.33518" /MaxDrop="3.1562" /score="14.9475399" /energy="-16" /TU="U2488" /idTUdmin="U2496" /TUdmin=5823 /isTUend="FALSE" /label="downshifts" CDS complement(2900155..2900394) /gene="yukD" /locus_tag="BSU_31900" /old_locus_tag="BSU31900" /function="11.1: Protein and peptide secretion and trafficking" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15576783, 16845009, 24798022" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15576783, 16845009, 24798022; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ESX secretion system YukD protein" /protein_id="NP_391068.1" /db_xref="EnsemblGenomes-Gn:BSU31900" /db_xref="EnsemblGenomes-Tr:CAB15178" /db_xref="InterPro:IPR014921" /db_xref="InterPro:IPR024962" /db_xref="InterPro:IPR029071" /db_xref="PDB:2BPS" /db_xref="SubtiList:BG12377" /db_xref="UniProtKB/Swiss-Prot:P71071" /translation="MYIDITIDLKHYNGSVFDLRLSDYHPVKKVIDIAWQAQSVSMPP REGHWIRVVNKDKVFSGECKLSDCGITNGDRLEIL*" /label="yukD CDS" gene complement(2900155..2900394) /gene="yukD" /locus_tag="BSU_31900" /old_locus_tag="BSU31900" /label="yukD gene" CDS complement(2900464..2900757) /gene="yukE" /locus_tag="BSU_31910" /old_locus_tag="BSU31910" /function="11.1: Protein and peptide secretion and trafficking" /experiment="publication(s) with functional evidences, PMID:11973144, 15576783, 22720735, 24798022, 24828531" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11973144, 15576783, 22720735, 24798022, 24828531; Product type t : transporter" /codon_start=1 /transl_table=11 /product="small WGX100 secreted protein (ESX-dependent secretion)" /protein_id="NP_391069.2" /db_xref="EnsemblGenomes-Gn:BSU31910" /db_xref="EnsemblGenomes-Tr:CAB15179" /db_xref="GOA:C0SP85" /db_xref="InterPro:IPR010310" /db_xref="InterPro:IPR036689" /db_xref="SubtiList:BG12378" /db_xref="UniProtKB/Swiss-Prot:C0SP85" /translation="MAGLIRVTPEELRAMAKQYGVESQEVLNQVDRLNRMISDLKSMW EGASSEAFADQYEQLKPSFIKMSDLLQDVNQQLDQTANTLESTDQDIANQIRG*" /label="yukE CDS" gene complement(2900464..2900757) /gene="yukE" /locus_tag="BSU_31910" /old_locus_tag="BSU31910" /label="yukE gene" downshifts complement(2900474) /Source="Nicolas_upshifts" /id="D1649" /incds=0 /nref=248 /ntot=268 /MaxReadThrough="6.21938" /MaxDrop="7.50121" /score="14.9475399" /energy="-16" /TU="U2488" /idTUdmin="U2496" /TUdmin=4155 /isTUend="FALSE" /label="downshifts" downshifts 2900751 /Source="Nicolas_upshifts" /id="D1650" /incds=0 /nref=1 /ntot=26 /MaxReadThrough="2.85718" /MaxDrop="3.33739" /score="43.0917981" /energy="-17.1" /TU="NA" /idTUdmin="U2487" /TUdmin="-242" /isTUend="FALSE" /label="downshifts" S_feature complement(2900758..2900836) /Source="Nicolas_S_feature" /locus_tag="new_3276435_3276513_c" /HighExp="T-1.10H, T1.0H, T-0.40H, T1.30H, BI, T2.30H, T3.0H, T-2.40H, T2.0H, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1226" promotor_-35 2900799..2900806 /Source="Nicolas_upshift_promotors" /id="U2487" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.485514485514486" /psig="0.76023976023976" /xcortree=715 /SigmaFactorBS="tattcctcattacctcctgtgccatcagcctaaatatgggct AATTCACTtatttttagaacgtCATTATTATAAAAACAGTttttcggcatagtcaaac a" /listShort="S1227" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2900816..2900835) /Source="Nicolas_upshift_promotors" /id="U2488" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.735264735264735" /psig=1 /xcortree=3086 /SigmaFactorBS="gtaaaccattggactcattttgtaaaattaaaacatattTGT TTGACtatgccgaaaaactGTTTTTATAATAATGACGTTctaaaaataagtgaattag c" /listShort="S1226, yukE, yukD, yukC, yukB, yueB, yueC, yueD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2900817 /Source="Nicolas_upshifts" /id="U2487" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.485514485514486" /psig="0.76023976023976" /xcortree=715 /SigmaFactorBS="tattcctcattacctcctgtgccatcagcctaaatatgggct AATTCACTtatttttagaacgtCATTATTATAAAAACAGTttttcggcatagtcaaac a" /listShort="S1227" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2900821..2900838 /Source="Nicolas_upshift_promotors" /id="U2487" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.485514485514486" /psig="0.76023976023976" /xcortree=715 /SigmaFactorBS="tattcctcattacctcctgtgccatcagcctaaatatgggct AATTCACTtatttttagaacgtCATTATTATAAAAACAGTttttcggcatagtcaaac a" /listShort="S1227" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2900836) /Source="Nicolas_upshifts" /id="U2488" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.735264735264735" /psig=1 /xcortree=3086 /SigmaFactorBS="gtaaaccattggactcattttgtaaaattaaaacatattTGT TTGACtatgccgaaaaactGTTTTTATAATAATGACGTTctaaaaataagtgaattag c" /listShort="S1226, yukE, yukD, yukC, yukB, yueB, yueC, yueD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2900850..2900857) /Source="Nicolas_upshift_promotors" /id="U2488" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.735264735264735" /psig=1 /xcortree=3086 /SigmaFactorBS="gtaaaccattggactcattttgtaaaattaaaacatattTGT TTGACtatgccgaaaaactGTTTTTATAATAATGACGTTctaaaaataagtgaattag c" /listShort="S1226, yukE, yukD, yukC, yukB, yueB, yueC, yueD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2900895..2900900 /Source="Nicolas_upshift_promotors" /id="U2489" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.523476523476524" /psig="0.523476523476524" /xcortree=769 /SigmaFactorBS="taattttacaaaatgagtccaatggtttACCCCGaatcactc aaaaatGACATATACTGTAAAGTAAAtaggtttattttcttaatcttctcttcattct c" /listShort="S1227" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2900915..2900934 /Source="Nicolas_upshift_promotors" /id="U2489" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.523476523476524" /psig="0.523476523476524" /xcortree=769 /SigmaFactorBS="taattttacaaaatgagtccaatggtttACCCCGaatcactc aaaaatGACATATACTGTAAAGTAAAtaggtttattttcttaatcttctcttcattct c" /listShort="S1227" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2900927..2901033 /Source="Nicolas_S_feature" /locus_tag="new_3276604_3276710" /HighExp="S8, C30, S7, S6, Pyr, Glucon, B60, LoTm, C90, M/G" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA" /TUshortPSig="0.523, 0.76" /TUlongSig="NA" /TUlongPSig="NA" /label="S1227" upshifts 2900927 /Source="Nicolas_upshifts" /id="U2489" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.523476523476524" /psig="0.523476523476524" /xcortree=769 /SigmaFactorBS="taattttacaaaatgagtccaatggtttACCCCGaatcactc aaaaatGACATATACTGTAAAGTAAAtaggtttattttcttaatcttctcttcattct c" /listShort="S1227" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2901102..2901108 /Source="Nicolas_upshift_promotors" /id="U2490" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.418581418581419" /psig="0.81918081918082" /xcortree=1909 /SigmaFactorBS="tctttccttaattagtcttgcctccgatgactttcttAGAAG ATtaataggataagcTGTCGTATTATATGAGACATacactgtcctgcaaaaaggcgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2901122..2901141 /Source="Nicolas_upshift_promotors" /id="U2490" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.418581418581419" /psig="0.81918081918082" /xcortree=1909 /SigmaFactorBS="tctttccttaattagtcttgcctccgatgactttcttAGAAG ATtaataggataagcTGTCGTATTATATGAGACATacactgtcctgcaaaaaggcgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2901125 /Source="Nicolas_upshifts" /id="U2490" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.418581418581419" /psig="0.81918081918082" /xcortree=1909 /SigmaFactorBS="tctttccttaattagtcttgcctccgatgactttcttAGAAG ATtaataggataagcTGTCGTATTATATGAGACATacactgtcctgcaaaaaggcgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2901230..2901233 /Source="Nicolas_upshift_promotors" /id="U2491" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.96103896103896" /xcortree=3188 /SigmaFactorBS="atagaacgtttctctcatgaaattgtttttttgcttctgttc tttgttGTTGattttcacaaacaacAACAATCATAATAAAAGGAAggggatgagatgt c" /listShort="yukF" /listLong="ald" /label="promotor_-35" upshifts 2901242 /Source="Nicolas_upshifts" /id="U2491" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.96103896103896" /xcortree=3188 /SigmaFactorBS="atagaacgtttctctcatgaaattgtttttttgcttctgttc tttgttGTTGattttcacaaacaacAACAATCATAATAAAAGGAAggggatgagatgt c" /listShort="yukF" /listLong="ald" /label="upshifts" promotor_-10 complement(2901245..2901264) /Source="Nicolas_upshift_promotors" /id="U2492" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.564435564435564" /psig="0.98901098901099" /xcortree=2439 /SigmaFactorBS="ggcatggtcataaatctccctacttttcgtgcttgatttctC TTTGACAtctcatccccttccTTTTATTATGATTGTTGTTGtttgtgaaaatcaacaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2901249..2901268 /Source="Nicolas_upshift_promotors" /id="U2491" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.96103896103896" /xcortree=3188 /SigmaFactorBS="atagaacgtttctctcatgaaattgtttttttgcttctgttc tttgttGTTGattttcacaaacaacAACAATCATAATAAAAGGAAggggatgagatgt c" /listShort="yukF" /listLong="ald" /label="promotor_-10" upshifts complement(2901267) /Source="Nicolas_upshifts" /id="U2492" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.564435564435564" /psig="0.98901098901099" /xcortree=2439 /SigmaFactorBS="ggcatggtcataaatctccctacttttcgtgcttgatttctC TTTGACAtctcatccccttccTTTTATTATGATTGTTGTTGtttgtgaaaatcaacaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 2901278..2902546 /gene="adeR" /locus_tag="BSU_31920" /old_locus_tag="BSU31920" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:22797752" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22797752; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional activator (AdeR-alanine)" /protein_id="NP_391070.2" /db_xref="EnsemblGenomes-Gn:BSU31920" /db_xref="EnsemblGenomes-Tr:CAB15180" /db_xref="GOA:P71073" /db_xref="InterPro:IPR010312" /db_xref="InterPro:IPR025736" /db_xref="InterPro:IPR029016" /db_xref="SubtiList:BG12379" /db_xref="UniProtKB/Swiss-Prot:P71073" /translation="MSKRNQARKVGRFMTMPNDPFKYSFDRLEDVADHISDVLRCPIT IEDVNHKLLAYSTHSDCTDPARTSTIIGRRVPEKVINKLWKDGTIPALLKTDQPIRVK QIDEVGLSNRVAISIWKNKQVLGFIWALEIQKTLSDEDLLTLQMAAKAVKNKLLKLQI RKTKNEERSQEFFWKMLTGHIHQEDDMADGFHKLGMAAPSEFSVMIIRINGELTEKIE QQLQYLQETTQQVYVLLATVDSNELIILTSPKTDHPFQDLKQFALSTQKQLKERYKIE DVSIAFGGIYNSISFVSRSYQEALSVLKTKERFAEETKHLFSFSELGIYQYLDVLNEK RKQAGHYNYSLSKLEQYDRDHQSNMVETLERFIEADSNVNTASKLLNIHVNTLNYRLK RISQIAEIDLKNVNQKFTIYLDIKLRHMDL*" /label="adeR CDS" gene 2901278..2902546 /gene="adeR" /locus_tag="BSU_31920" /old_locus_tag="BSU31920" /label="adeR gene" promotor_-35 complement(2901279..2901286) /Source="Nicolas_upshift_promotors" /id="U2492" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.564435564435564" /psig="0.98901098901099" /xcortree=2439 /SigmaFactorBS="ggcatggtcataaatctccctacttttcgtgcttgatttctC TTTGACAtctcatccccttccTTTTATTATGATTGTTGTTGtttgtgaaaatcaacaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 2902606..2902625 /Source="Nicolas_upshift_promotors" /id="U2493" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.696303696303696" /psig="0.996003996003996" /xcortree=1594 /SigmaFactorBS="tcacaaatccatgtttttttattttcttaatcaaacaaagaa ttttccaaaatatCAAGCTACACTAAAAATATCacatatacaggaggagacagatatg a" /listShort="ald, yukJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2902611 /Source="Nicolas_upshifts" /id="U2493" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.696303696303696" /psig="0.996003996003996" /xcortree=1594 /SigmaFactorBS="tcacaaatccatgtttttttattttcttaatcaaacaaagaa ttttccaaaatatCAAGCTACACTAAAAATATCacatatacaggaggagacagatatg a" /listShort="ald, yukJ" /GFF_Attribute="listLong" /label="upshifts" CDS 2902648..2903784 /gene="ald" /locus_tag="BSU_31930" /old_locus_tag="BSU31930" /EC_number="1.4.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:488097, 8226620, 22720735, 22797752, 26202482" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 488097, 8226620, 22720735, 22797752, 26202482; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-alanine dehydrogenase (NAD-dependent)" /protein_id="NP_391071.1" /db_xref="EnsemblGenomes-Gn:BSU31930" /db_xref="EnsemblGenomes-Tr:CAB15181" /db_xref="GOA:Q08352" /db_xref="InterPro:IPR007698" /db_xref="InterPro:IPR007886" /db_xref="InterPro:IPR008141" /db_xref="InterPro:IPR008142" /db_xref="InterPro:IPR008143" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10468" /db_xref="UniProtKB/Swiss-Prot:Q08352" /translation="MIIGVPKEIKNNENRVALTPGGVSQLISNGHRVLVETGAGLGSG FENEAYESAGAEIIADPKQVWDAEMVMKVKEPLPEEYVYFRKGLVLFTYLHLAAEPEL AQALKDKGVTAIAYETVSEGRTLPLLTPMSEVAGRMAAQIGAQFLEKPKGGKGILLAG VPGVSRGKVTIIGGGVVGTNAAKMAVGLGADVTIIDLNADRLRQLDDIFGHQIKTLIS NPVNIADAVAEADLLICAVLIPGAKAPTLVTEEMVKQMKPGSVIVDVAIDQGGIVETV DHITTHDQPTYEKHGVVHYAVANMPGAVPRTSTIALTNVTVPYALQIANKGAVKALAD NTALRAGLNTANGHVTYEAVARDLGYEYVPAEKALQDESSVAGA*" /label="ald CDS" gene 2902648..2903784 /gene="ald" /locus_tag="BSU_31930" /old_locus_tag="BSU31930" /label="ald gene" downshifts 2903784 /Source="Nicolas_upshifts" /id="D1651" /incds=0 /nref=42 /ntot=190 /MaxReadThrough="5.86626" /MaxDrop="4.4689" /score="41.2794059" /energy="-14.2" /TU="U2493" /idTUdmin="U2493" /TUdmin="-769" /isTUend="FALSE" /label="downshifts" promotor_-35 2903833..2903841 /Source="Nicolas_upshift_promotors" /id="U2494" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=521 /SigmaFactorBS="ataagcttgcagaaagatttctgcaggcttttttatttttta AAAGGAAAAaagagaccattTCACGAATTATGACTATGAagttgatcataaaggagga t" /listShort="yukJ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2903851 /Source="Nicolas_upshifts" /id="U2494" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=521 /SigmaFactorBS="ataagcttgcagaaagatttctgcaggcttttttatttttta AAAGGAAAAaagagaccattTCACGAATTATGACTATGAagttgatcataaaggagga t" /listShort="yukJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2903853..2903871 /Source="Nicolas_upshift_promotors" /id="U2494" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=521 /SigmaFactorBS="ataagcttgcagaaagatttctgcaggcttttttatttttta AAAGGAAAAaagagaccattTCACGAATTATGACTATGAagttgatcataaaggagga t" /listShort="yukJ" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2903896..2904573 /gene="yukJ" /locus_tag="BSU_31945" /old_locus_tag="BSU31945" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391073.2" /db_xref="EnsemblGenomes-Gn:BSU31945" /db_xref="EnsemblGenomes-Tr:CAB15183" /db_xref="InterPro:IPR019268" /db_xref="SubtiList:BG12380" /db_xref="UniProtKB/Swiss-Prot:C0SPB1" /translation="MAVQQYGVLKGIVLDMKRETDDDSPHFQVKMLGEENTYYRCAIN VMSSSEESEVLYLADDQFDSGSITILPNMPYGYTRINEANREVALDYVRGNLFDPREM KPLPHEITGPDNDLNDFIETYMKKAQDEKTPVYIFGSKFGPEQAADKIFGFTPTNGMH NIHMNQGNAMDTRWKKDNGSWHDGGILIQFADQWAAVFLAFLSQSWCTDENGNPVRDC DHTQTSA*" /label="yukJ CDS" gene 2903896..2904573 /gene="yukJ" /locus_tag="BSU_31945" /old_locus_tag="BSU31945" /label="yukJ gene" downshifts 2904557 /Source="Nicolas_upshifts" /id="D1652" /incds=0 /nref=37 /ntot=185 /MaxReadThrough="3.39608" /MaxDrop="5.40829" /score="9.49891506" /energy="-12" /TU="U2494" /idTUdmin="U2493" /TUdmin=4 /isTUend="TRUE" /label="downshifts" CDS complement(2904617..2904826) /gene="mbtH" /locus_tag="BSU_31959" /old_locus_tag="BSU31959" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11112781, 20845982, 21890635, 24975514, 28880538; Product type r: regulator" /codon_start=1 /transl_table=11 /product="stimulator of DhbF tyrosine adenylation activity" /protein_id="YP_003097779.1" /db_xref="EnsemblGenomes-Gn:BSU31959" /db_xref="EnsemblGenomes-Tr:CAX52685" /db_xref="InterPro:IPR005153" /db_xref="UniProtKB/Swiss-Prot:C0H3Q6" /translation="MANPFENADGTYLVLVNEEGQYSLWPGFIDVPSGWTVVHEQKGR EACLDYIQSHWSDMRPNSLKTVENV*" /label="mbtH CDS" gene complement(2904617..2904826) /gene="mbtH" /locus_tag="BSU_31959" /old_locus_tag="BSU31959" /label="mbtH gene" downshifts complement(2904629) /Source="Nicolas_upshifts" /id="D1653" /incds=0 /nref=106 /ntot=174 /MaxReadThrough="1.39981" /MaxDrop="6.23998" /score="17.380299" /energy="-12" /TU="NA" /idTUdmin="U2496" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2904842..2911978) /gene="dhbF" /locus_tag="BSU_31960" /old_locus_tag="BSU31960" /EC_number="2.7.7.-" /EC_number="5.1.1.-" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11112781, 12354229, 16672620, 18957859, 26284661, 27731335" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11112781, 12354229, 16672620, 18957859, 26284661, 27731335; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="siderophore 2,3-dihydroxybenzoate-glycine-threonine trimeric ester bacillibactin synthetase" /protein_id="NP_391076.3" /db_xref="EnsemblGenomes-Gn:BSU31960" /db_xref="EnsemblGenomes-Tr:CAB15186" /db_xref="GOA:P45745" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR001031" /db_xref="InterPro:IPR001242" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR020802" /db_xref="InterPro:IPR020806" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="InterPro:IPR029058" /db_xref="InterPro:IPR036736" /db_xref="SubtiList:BG11243" /db_xref="UniProtKB/Swiss-Prot:P45745" /translation="MPDTKDLQYSLTGAQTGIWFAQQLDPDNPIYNTAEYIEINGPVN IALFEEALRHVIKEAESLHVRFGENMDGPWQMINPSPDVQLHVIDVSSEPDPEKTALN WMKADLAKPVDLGYAPLFNEALFIAGPDRFFWYQRIHHIAIDGFGFSLIAQRVASTYT ALIKGQTAKSRSFGSLQAILEEDTDYRGSEQYEKDRQFWLDRFADAPEVVSLADRAPR TSNSFLRHTAYLPPSDVNALKEAARYFSGSWHEVMIAVSAVYVHRMTGSEDVVLGLPM MGRIGSASLNVPAMVMNLLPLRLTVSSSMSFSELIQQISREIRSIRRHHKYRHEELRR DLKLIGENHRLFGPQINLMPFDYGLDFAGVRGTTHNLSAGPVDDLSINVYDRTDGSGL RIDVDANPEVYSESDIKLHQQRILQLLQTASAGEDMLIGQMELLLPEEKEKVISKWNE TAKSEKLVSLQDMFEKQAVLTPERIALMCDDIQVNYRKLNEEANRLARLLIEKGIGPE QFVALALPRSPEMVASMLGVLKTGAAYLPLDPEFPADRISYMLEDAKPSCIITTEEIA ASLPDDLAVPELVLDQAVTQEIIKRYSPENQDVSVSLDHPAYIIYTSGSTGRPKGVVV TQKSLSNFLLSMQEAFSLGEEDRLLAVTTVAFDISALELYLPLISGAQIVIAKKETIR EPQALAQMIENFDINIMQATPTLWHALVTSEPEKLRGLRVLVGGEALPSGLLQELQDL HCSVTNLYGPTETTIWSAAAFLEEGLKGVPPIGKPIWNTQVYVLDNGLQPVPPGVVGE LYIAGTGLARGYFHRPDLTAERFVADPYGPPGTRMYRTGDQARWRADGSLDYIGRADH QIKIRGFRIELGEIDAVLANHPHIEQAAVVVREDQPGDKRLAAYVVADAAIDTAELRR YMGASLPDYMVPSAFVEMDELPLTPNGKLDRKALPAPDFSTSVSDRAPRTPQEEILCD LFAEVLGLARVGIDDSFFELGGHSLLAARLMSRIREVMGAELGIAKLFDEPTVAGLAA HLDLAQSACPALQRAERPEKIPLSFAQRRLWFLHCLEGPSPTYNIPVAVRLSGELDQG LLKAALYDLVCRHESLRTIFPESQGTSYQHILDADRACPELHVTEIAEKELSDRLAEA VRYSFDLAAEPAFRAELFVIGPDEYVLLLLVHHIVGDGWSLTPLTRDLGTAYAARCHG RSPEWAPLAVQYADYALWQQELLGNEDDPNSLIAGQLAFWKETLKNLPDQLELPTDYS RPAEPSHDGDTIHFRIEPEFHKRLQELARANRVSLFMVLQSGLAALLTRLGAGTDIPI GSPIAGRNDDALGDLVGLFINTLVLRTDTSGDPSFRELLDRVREVNLAAYDNQDLPFE RLVEVLNPARSRATHPLFQIMLAFQNTPDAELHLPDMESSLRINSVGSAKFDLTLEIS EDRLADGTPNGMEGLLEYSTDLFKRETAQALADRLMRLLEAAESDPDEQIGNLDILAP EEHSSMVTDWQSVSEKIPHACLPEQFEKQAALRPDAIAVVYENQELSYAELNERANRL ARMMISEGVGPEQFVALALPRSLEMAVGLLAVLKAGAAYLPLDPDYPADRIAFMLKDA QPAFIMTNTKAANHIPPVENVPKIVLDDPELAEKLNTYPAGNPKNKDRTQPLSPLNTA YVIYTSGSTGVPKGVMIPHQNVTRLFAATEHWFRFSSGDIWTMFHSYAFDFSVWEIWG PLLHGGRLVIVPHHVSRSPEAFLRLLVKEGVTVLNQTPSAFYQFMQAEREQPDLGQAL SLRYVIFGGEALELSRLEDWYNRHPENRPQLINMYGITETTVHVSYIELDRSMAALRA NSLIGCGIPDLGVYVLDERLQPVPPGVAGELYVSGAGLARGYLGRPGLTSERFIADPF GPPGTRMYRTGDVARLRADGSLDYVGRADHQVKIRGFRIELGEIEAALVQHPQLEDAA VIVREDQPGDKRLAAYVIPSEETFDTAELRRYAAERLPDYMVPAAFVTMKELPLTPNG KLDRKALPAPDFAAAVTGRGPRTPQEEILCDLFMEVLHLPRVGIDDRFFDLGGHSLLA VQLMSRIREALGVELSIGNLFEAPTVAGLAERLEMGSSQSALDVLLPLRTSGDKPPLF CVHPAGGLSWCYAGLMTNIGTDYPIYGLQARGIGQREELPKTLDDMAADYIKQIRTVQ PKGPYHLLGWSLGGNVVQAMATQLQNQGEEVSLLVMLDAYPNHFLPIKEAPDDEEALI ALLALGGYDPDSLGEKPLDFEAAIEILRRDGSALASLDETVILNLKNTYVNSVGILGS YKPKTFRGNVLFFRSTIIPEWFDPIEPDSWKPYINGQIEQIDIDCRHKDLCQPEPLAQ IGKVLAVKLEELNK*" /label="dhbF CDS" gene complement(2904842..2911978) /gene="dhbF" /locus_tag="BSU_31960" /old_locus_tag="BSU31960" /label="dhbF gene" CDS complement(2911998..2912936) /gene="dhbB" /locus_tag="BSU_31970" /old_locus_tag="BSU31970" /EC_number="3.3.2.1" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8921902, 9214294, 11112781, 11790741, 12354229, 16672620, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isochorismatase (siderophore specific)" /protein_id="NP_391077.1" /db_xref="EnsemblGenomes-Gn:BSU31970" /db_xref="EnsemblGenomes-Tr:CAB15187" /db_xref="GOA:P45743" /db_xref="InterPro:IPR000868" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR016291" /db_xref="InterPro:IPR036380" /db_xref="InterPro:IPR036736" /db_xref="SubtiList:BG11241" /db_xref="UniProtKB/Swiss-Prot:P45743" /translation="MAIPAIQPYQMPTASDMPQNKVSWVPDPNRAVLLIHDMQNYFVD AFTAGASPVTELSANIRKLKNQCVQLGIPVVYTAQPGSQNPDDRALLTDFWGPGLNSG PYEEKIITELAPEDDDLVLTKWRYSAFKRTNLLEMMRKEGRDQLIITGIYAHIGCLVT ACEAFMEDIKAFFVGDAVADFSLEKHQMALEYAAGRCAFTVMTDSLLDQLQNAPADVQ KTSANTGKKNVFTCENIRKQIAELLQETPEDITDQEDLLDRGLDSVRIMTLVEQWRRE GAEVTFVELAERPTIEEWQKLLTTRSQQVLPNADYL*" /label="dhbB CDS" gene complement(2911998..2912936) /gene="dhbB" /locus_tag="BSU_31970" /old_locus_tag="BSU31970" /label="dhbB gene" CDS complement(2912964..2914583) /gene="dhbE" /locus_tag="BSU_31980" /old_locus_tag="BSU31980" /EC_number="2.7.7.58" /EC_number="6.3.2.-" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8921902, 9214294, 11112781, 11790741, 12354229, 12221282, 16672620, 16403027, 23352143, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8921902, 9214294, 11112781, 11790741, 12354229, 12221282, 16672620, 16403027, 23352143, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2,3-dihydroxybenzoate-AMP ligase" /protein_id="NP_391078.1" /db_xref="EnsemblGenomes-Gn:BSU31980" /db_xref="EnsemblGenomes-Tr:CAB15188" /db_xref="GOA:P40871" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR011963" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="PDB:1MD9" /db_xref="PDB:1MDB" /db_xref="PDB:1MDF" /db_xref="SubtiList:BG11020" /db_xref="UniProtKB/Swiss-Prot:P40871" /translation="MLKGFTPWPDELAETYRKNGCWAGETFGDLLRDRAAKYGDRIAI TCGNTHWSYRELDTRADRLAAGFQKLGIQQMDRVVVQLPNIKEFFEVIFALFRLGALP VFALPSHRSSEITYFCEFAEAAAYIIPDAYSGFDYRSLARQVQSKLPTLKNIIVAGEA EEFLPLEDLHAEPVKLPEVKSSDVAFLQLSGGSTGLSKLIPRTHDDYIYSLKRSVEVC WLDHSTVYLAALPMAHNYPLSSPGVLGVLYAGGRVVLSPSPSPDDAFPLIEREKVTIT ALVPPLAMVWMDAASSRRDDLSSLQVLQVGGAKFSAEAARRVKAVFGCTLQQVFGMAE GLVNYTRLDDPEEIIVNTQGKPMSPYDEMRVWDDHDRDVKPGETGHLLTRGPYTIRGY YKAEEHNAASFTEDGFYRTGDIVRLTRDGYIVVEGRAKDQINRGGEKVAAEEVENHLL AHPAVHDAAMVSMPDQFLGERSCVFIIPRDEAPKAAELKAFLRERGLAAYKIPDRVEF VESFPQTGVGKVSKKALREAISEKLLAGFKK*" /label="dhbE CDS" gene complement(2912964..2914583) /gene="dhbE" /locus_tag="BSU_31980" /old_locus_tag="BSU31980" /label="dhbE gene" CDS complement(2914612..2915808) /gene="dhbC" /locus_tag="BSU_31990" /old_locus_tag="BSU31990" /EC_number="5.4.4.2" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 12354229, 16672620, 19777807, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isochorismate synthase (siderophore-specific)" /protein_id="NP_391079.2" /db_xref="EnsemblGenomes-Gn:BSU31990" /db_xref="EnsemblGenomes-Tr:CAB15189" /db_xref="GOA:P45744" /db_xref="InterPro:IPR004561" /db_xref="InterPro:IPR005801" /db_xref="InterPro:IPR015890" /db_xref="SubtiList:BG11242" /db_xref="UniProtKB/Swiss-Prot:P45744" /translation="MLDQNVITETKAEHLLHEYQPGAFFLASPHRVLLAKGICEIVPE ADGQNQMETLSGRIAEALRQAKQSGQSRPLVVGAVPFDQVKAARLVVPEEVRWSGPLQ FDHEEKEQQAGHTYHIKPVPEPEDYKNGVEQGLARIADGTLSKIVLSRSLHLTSPEPI QTDELLRHLAQHNSHGYTFAADVSSQEETSPRRTLLGASPELLVSRMGTQVVSNPLAG SRPRSNDPVEDQRRAAELLSSAKDLHEHAVVADAVAAALRPFCRTLEVPEKPSLIKTE TMWHLSSVIKGELSDPSVTALELAAALHPTPAVCGTPTDLAREAILSIEPFDRGFFTG MVGWCDDAGDGEWIVTIRCAEAEERSLRLYAGAGVVAGSKPEDELQETSAKFRTMLRA MGVDHI*" /label="dhbC CDS" gene complement(2914612..2915808) /gene="dhbC" /locus_tag="BSU_31990" /old_locus_tag="BSU31990" /label="dhbC gene" promotor_-35 2915656..2915663 /Source="Nicolas_upshift_promotors" /id="U2495" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.75024975024975" /psig="0.98001998001998" /xcortree=1925 /SigmaFactorBS="acgcctctgcaattcggccagaaagggtttcCATTTGGTttt gcccgtctgccTCCGGTACAATTTCACATATgcctttcgctaacagtacacgatgagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2915678..2915697 /Source="Nicolas_upshift_promotors" /id="U2495" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.75024975024975" /psig="0.98001998001998" /xcortree=1925 /SigmaFactorBS="acgcctctgcaattcggccagaaagggtttcCATTTGGTttt gcccgtctgccTCCGGTACAATTTCACATATgcctttcgctaacagtacacgatgagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2915685 /Source="Nicolas_upshifts" /id="U2495" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.75024975024975" /psig="0.98001998001998" /xcortree=1925 /SigmaFactorBS="acgcctctgcaattcggccagaaagggtttcCATTTGGTttt gcccgtctgccTCCGGTACAATTTCACATATgcctttcgctaacagtacacgatgagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2915834..2916619) /gene="dhbA" /locus_tag="BSU_32000" /old_locus_tag="BSU32000" /EC_number="1.3.1.28" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12354229, 16672620, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 16672620, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase" /protein_id="NP_391080.2" /db_xref="EnsemblGenomes-Gn:BSU32000" /db_xref="EnsemblGenomes-Tr:CAB15190" /db_xref="GOA:P39071" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR003560" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11019" /db_xref="UniProtKB/Swiss-Prot:P39071" /translation="MNAKGIEGKIAFITGAAQGIGEAVARTLASQGAHIAAVDYNPEK LEKVVSSLKAEGRHAEAFPADVRDSAAIDEITARIEREMGPIDILVNVAGVLRPGLIH SLSDEEWEATFSVNSTGVFNASRSVSKYMMDRRSGSIVTVGSNAAGVPRTSMAAYASS KAAAVMFTKCLGLELAEYNIRCNIVSPGSTETDMQWSLWADENGAEQVIKGSLETFKT GIPLKKLAKPSDIADAVLFLVSGQAGHITMHNLCVDGGATLGV*" /label="dhbA CDS" gene complement(2915834..2916619) /gene="dhbA" /locus_tag="BSU_32000" /old_locus_tag="BSU32000" /label="dhbA gene" S_feature complement(2916620..2916729) /Source="Nicolas_S_feature" /locus_tag="new_3292297_3292406_c" /HighExp="HiOs, GM 15, B60, nit, GM 10, GM 25, B36, GM 60, dia0, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1228" promotor_-10 complement(2916724..2916743) /Source="Nicolas_upshift_promotors" /id="U2496" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.617382617382617" /psig=1 /xcortree=2114 /SigmaFactorBS="aaaaatatttgtcactgaaattataTTTGACTGtcacatgac atttGGATATGATTATTTTTATAAttgataatgataatcattatcaatagattgcgtt t" /listShort="S1228, dhbA, dhbC, dhbE, dhbB, dhbF, ybdZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2916729) /Source="Nicolas_upshifts" /id="U2496" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.617382617382617" /psig=1 /xcortree=2114 /SigmaFactorBS="aaaaatatttgtcactgaaattataTTTGACTGtcacatgac atttGGATATGATTATTTTTATAAttgataatgataatcattatcaatagattgcgtt t" /listShort="S1228, dhbA, dhbC, dhbE, dhbB, dhbF, ybdZ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2916731..2916812) /Source="Nicolas_S_feature" /locus_tag="new_3292408_3292489_c" /HighExp="HiOs, B60, nit, B36, GM 45, GM 10, BI, GM 15, GM 25, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1229" promotor_-35 complement(2916757..2916764) /Source="Nicolas_upshift_promotors" /id="U2496" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.617382617382617" /psig=1 /xcortree=2114 /SigmaFactorBS="aaaaatatttgtcactgaaattataTTTGACTGtcacatgac atttGGATATGATTATTTTTATAAttgataatgataatcattatcaatagattgcgtt t" /listShort="S1228, dhbA, dhbC, dhbE, dhbB, dhbF, ybdZ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2916813..2917682) /gene="besA" /locus_tag="BSU_32010" /old_locus_tag="BSU32010" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12354229, 16889643, 19673474, 26284661, 28283524; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bacillibactin trilactone hydrolase" /protein_id="NP_391081.2" /db_xref="EnsemblGenomes-Gn:BSU32010" /db_xref="EnsemblGenomes-Tr:CAB15191" /db_xref="GOA:O32102" /db_xref="InterPro:IPR000801" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG13974" /db_xref="UniProtKB/Swiss-Prot:O32102" /translation="MKEQTTDRTNGGTSNAFTIPGTEVRMMSSRNENRTYHIFISKPS TPPPPAGYPVIYLLDANSVFGTMTEAVRIQGRRPEKTGVIPAVIVGIGYETAEPFSSA RHRDFTMPTAQSKLPERPDGREWPEHGGAEGFFRFIEEDLKPEIERDYQIDKKRQTIF GHSLGGLFVLQVLLTKPDAFQTYIAGSPSIHWNKPFILKKTDHFVSLTKKNNQPINIL LAAGELEQHHKSRMNDNARELYERLAVLSEQGIRAEFCEFSGEGHISVLPVLVSRALR FALHPDGPHLSMG*" /label="besA CDS" gene complement(2916813..2917682) /gene="besA" /locus_tag="BSU_32010" /old_locus_tag="BSU32010" /label="besA gene" S_feature complement(2917683..2917763) /Source="Nicolas_S_feature" /locus_tag="new_3293360_3293440_c" /HighExp="HiOs, B60, nit, GM 15, BI, B36, LoTm, T-5.40H, Lbexp, T-4.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1230" promotor_-10 complement(2917747..2917766) /Source="Nicolas_upshift_promotors" /id="U2497" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.653346653346653" /psig=1 /xcortree=2115 /SigmaFactorBS="ttatttgatcaaggtgccttttttattcgggaaaaaGTTGAC TTtctttggaagaaaACCTATTATTTGAGGTGTCTagttgatagtgaaaatcattatc a" /listShort="S1230, besA, S1229, S1228, dhbA, dhbC, dhbE, dhbB, dhbF, ybdZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2917763) /Source="Nicolas_upshifts" /id="U2497" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.653346653346653" /psig=1 /xcortree=2115 /SigmaFactorBS="ttatttgatcaaggtgccttttttattcgggaaaaaGTTGAC TTtctttggaagaaaACCTATTATTTGAGGTGTCTagttgatagtgaaaatcattatc a" /listShort="S1230, besA, S1229, S1228, dhbA, dhbC, dhbE, dhbB, dhbF, ybdZ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2917780..2917787) /Source="Nicolas_upshift_promotors" /id="U2497" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.653346653346653" /psig=1 /xcortree=2115 /SigmaFactorBS="ttatttgatcaaggtgccttttttattcgggaaaaaGTTGAC TTtctttggaagaaaACCTATTATTTGAGGTGTCTagttgatagtgaaaatcattatc a" /listShort="S1230, besA, S1229, S1228, dhbA, dhbC, dhbE, dhbB, dhbF, ybdZ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2917896..2918492) /gene="yuiH" /locus_tag="BSU_32020" /old_locus_tag="BSU32020" /EC_number="1.7.3.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11598126, 16341843, 21190336; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative molybdopterin containing enzyme subunit" /protein_id="NP_391082.1" /db_xref="EnsemblGenomes-Gn:BSU32020" /db_xref="EnsemblGenomes-Tr:CAB15192" /db_xref="GOA:O32103" /db_xref="InterPro:IPR000572" /db_xref="InterPro:IPR036374" /db_xref="SubtiList:BG13973" /db_xref="UniProtKB/Swiss-Prot:O32103" /translation="MYFGKTRQSDQSGRVPPNQNVTTSFPVLHTGDVPYYEDMTKWNL QVYGLVDHPMLLSFEDVKAFPRYESKNDIHCVTGWSRLDNVWQGVRACDIAEKAGVKE EAGYVILHAEEGWTTNLPLDDFLAETSLLAYAHNGEPLTPEHGFPLRGVFPHLYFWKS AKWLRGIQFTKENHPGFWERNGYHMRGDPWQNQRFTWD*" /label="yuiH CDS" gene complement(2917896..2918492) /gene="yuiH" /locus_tag="BSU_32020" /old_locus_tag="BSU32020" /label="yuiH gene" S_feature complement(2918493..2918577) /Source="Nicolas_S_feature" /locus_tag="new_3294170_3294254_c" /HighExp="H2O2, Paraq, Cold, dia15, G135, B36, G180, B60, LoTm, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.204" /TUlongSig="NA" /TUlongPSig="NA" /label="S1231" promotor_-35 2918528..2918535 /Source="Nicolas_upshift_promotors" /id="U2498" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2920 /SigmaFactorBS="aaatacatatgggcctcctttttgttaacctaatttaaaatc aTGTTGACAatctttttgttcttTATTACTCTATGATTGTGTAtgtcaacctaagggg g" /listShort="bioYB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2918545 /Source="Nicolas_upshifts" /id="U2498" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2920 /SigmaFactorBS="aaatacatatgggcctcctttttgttaacctaatttaaaatc aTGTTGACAatctttttgttcttTATTACTCTATGATTGTGTAtgtcaacctaagggg g" /listShort="bioYB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2918550..2918569 /Source="Nicolas_upshift_promotors" /id="U2498" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2920 /SigmaFactorBS="aaatacatatgggcctcctttttgttaacctaatttaaaatc aTGTTGACAatctttttgttcttTATTACTCTATGATTGTGTAtgtcaacctaagggg g" /listShort="bioYB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2918571..2918585) /Source="Nicolas_upshift_promotors" /id="U2499" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.724275724275724" /psig="0.203796203796204" /xcortree=588 /SigmaFactorBS="gccaatcagcgccatatctcccgcacgaagtttacgttgtTT CATcgttgttCCCCCTTAGGTTGACatacacaatcatagagtaataaagaacaaaaag a" /listShort="S1231, yuiH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2918577) /Source="Nicolas_upshifts" /id="U2499" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.724275724275724" /psig="0.203796203796204" /xcortree=588 /SigmaFactorBS="gccaatcagcgccatatctcccgcacgaagtttacgttgtTT CATcgttgttCCCCCTTAGGTTGACatacacaatcatagagtaataaagaacaaaaag a" /listShort="S1231, yuiH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2918593..2918597) /Source="Nicolas_upshift_promotors" /id="U2499" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.724275724275724" /psig="0.203796203796204" /xcortree=588 /SigmaFactorBS="gccaatcagcgccatatctcccgcacgaagtttacgttgtTT CATcgttgttCCCCCTTAGGTTGACatacacaatcatagagtaataaagaacaaaaag a" /listShort="S1231, yuiH" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2918593..2919195 /gene="bioYB" /locus_tag="BSU_32030" /old_locus_tag="BSU32030" /function="16.1: Circulate" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11717296, 15849754, 16850406, 24816803; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative biotin transporter" /protein_id="NP_391083.1" /db_xref="EnsemblGenomes-Gn:BSU32030" /db_xref="EnsemblGenomes-Tr:CAB15193" /db_xref="GOA:O32104" /db_xref="InterPro:IPR003784" /db_xref="SubtiList:BG13972" /db_xref="UniProtKB/Swiss-Prot:O32104" /translation="MKQRKLRAGDMALIGMFAALMAVGANITSVAPFLQVAGIPLSMQ PFFCLLAALLLGSKRAAIAMIVYALVGLAGAPVFAQFSAGFAPFAGKSGGFIISYIPA AFAAGWFLERNIQPSKIRFLIASLIGTAIMYLIGTTYMYLALKLWIHTPVSYGTAWGF MIWFMVKDTALAVILSFIAPAIYRSIHKATGFNRNHISST*" /label="bioYB CDS" gene 2918593..2919195 /gene="bioYB" /locus_tag="BSU_32030" /old_locus_tag="BSU32030" /label="bioYB gene" downshifts 2919181 /Source="Nicolas_upshifts" /id="D1654" /incds=0 /nref=145 /ntot=206 /MaxReadThrough="3.24182" /MaxDrop="6.72885" /score="12.6395055" /energy="-6.3" /TU="U2498" /idTUdmin="U2498" /TUdmin="-24" /isTUend="FALSE" /label="downshifts" CDS complement(2919265..2920593) /gene="hisP" /locus_tag="BSU_32040" /old_locus_tag="BSU32040" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15135544, 15849754, 16850406, 23504016; Product type t : transporter" /codon_start=1 /transl_table=11 /product="histidine / basic amino acid transporter" /protein_id="NP_391084.1" /db_xref="EnsemblGenomes-Gn:BSU32040" /db_xref="EnsemblGenomes-Tr:CAB15194" /db_xref="GOA:O32105" /db_xref="InterPro:IPR018461" /db_xref="InterPro:IPR032813" /db_xref="SubtiList:BG13971" /db_xref="UniProtKB/Swiss-Prot:O32105" /translation="MNAVVIAVLLMLVLSLLRVNIVIALIIGALAGGLTGGLGLGETV KAFTDGLGGNATVAVSYAMLGAFAAALTKTGLPDAMVEASVKLIGNKEDSRKKALSKV LIVLIILIVSCFSQNVVPVHIAFIPVLIPPLLKIFNELEMDRRLIACVITFGLTAPYI LLPVGFGQIFQGMLKDNMADAGLNVPLADIPYALIIPVAGMVVGLILSVIVYRKPKQY ETKDISGAEASPYTRKSIGIAVLAIVVSLGVQLYLSQTLGVEGMIMGALAGLIVLFVS GVMKRDEADSLITDGMVLMAFIGFVMLVAAGFSNVLTKTGDVESLVKTSAGFIGHSQS LGALLMLIVGLLITMGIGSSFATIPVITTIFVPLCMQLGFSPMATIAIIGAAAALGDA GSPASDSTLGPTSGLSADGQHHHIWDTCVPTFIFYNIPLVIFGWIAALVL*" /label="hisP CDS" gene complement(2919265..2920593) /gene="hisP" /locus_tag="BSU_32040" /old_locus_tag="BSU32040" /label="hisP gene" downshifts complement(2919281) /Source="Nicolas_upshifts" /id="D1655" /incds=0 /nref=14 /ntot=114 /MaxReadThrough="4.26298" /MaxDrop="4.37949" /score="18.6861113" /energy="-15.4" /TU="U2500" /idTUdmin="U2500" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2920647..2920666) /Source="Nicolas_upshift_promotors" /id="U2500" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=2776 /SigmaFactorBS="ggattttttcttccgaaatcttTAGTTGACtaaagtggatcg gtTATGATACGATACGTTCGTActttatttatctactacattagcaaactaaaggatt t" /listShort="yuiF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2920650) /Source="Nicolas_upshifts" /id="U2500" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=2776 /SigmaFactorBS="ggattttttcttccgaaatcttTAGTTGACtaaagtggatcg gtTATGATACGATACGTTCGTActttatttatctactacattagcaaactaaaggatt t" /listShort="yuiF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2920681..2920688) /Source="Nicolas_upshift_promotors" /id="U2500" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=2776 /SigmaFactorBS="ggattttttcttccgaaatcttTAGTTGACtaaagtggatcg gtTATGATACGATACGTTCGTActttatttatctactacattagcaaactaaaggatt t" /listShort="yuiF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2920740..2922242) /gene="pepA" /locus_tag="BSU_32050" /old_locus_tag="BSU32050" /EC_number="3.4.11.1" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8057849, 9864319, 10449417, 26936797; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytosol aminopeptidase" /protein_id="NP_391085.1" /db_xref="EnsemblGenomes-Gn:BSU32050" /db_xref="EnsemblGenomes-Tr:CAB15195" /db_xref="GOA:O32106" /db_xref="InterPro:IPR000819" /db_xref="InterPro:IPR008283" /db_xref="InterPro:IPR011356" /db_xref="InterPro:IPR023042" /db_xref="SubtiList:BG13970" /db_xref="UniProtKB/Swiss-Prot:O32106" /translation="MFYAVQQSEHTETLVVGLFQKSQLTGKALEIDEMLEGHLTQLLK EGDVSAKPNQVSKVFPPSSAGMKRIYFVGLGREANYSFEQAKERFAHVFQAIHKDRKQ ETAVLLDTFISEDVPPADAAHALAESCLLASYEVQDYKHKSNEPDKQIEAVYVVTDED TQEVQAGLRVGQAYGQGTNSARTLVNMPGNMLTATDLASYAEELAAKYDFECEILEKS EMEELGMGGILAVNQGSTEPPKMIVLKYQGKKEWEDVVGLVGKGITFDTGGYSIKTKS GIVGMKSDMGGAAAVLGAMETIGELRPEQNVLCVIPSTDNMISGGAMKPDDVIVSLSG KTIEILNTDAEGRLVLADGITYAKQHGASVLVDVATLTGGVVVALGTETTGAMTNDQS FYQQVADAAQECGEAIWQLPITEKDKKRVKSSQMADLSNSPGREGHAIMAGTFLGEFA ESTPWVHLDIAGTATANKATCFGPAGATGVMARTLATLAERFTLEEDKNE*" /label="pepA CDS" gene complement(2920740..2922242) /gene="pepA" /locus_tag="BSU_32050" /old_locus_tag="BSU32050" /label="pepA gene" downshifts complement(2920755) /Source="Nicolas_upshifts" /id="D1656" /incds=0 /nref=149 /ntot=220 /MaxReadThrough="4.44151" /MaxDrop="5.59726" /score="31.6277104" /energy="-16" /TU="NA" /idTUdmin="U2503" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature 2921807..2921821 /Source="Nicolas_upshift_promotors" /id="U2501" /multdbtbs="-" /comp="M19" /sig="Sig-" /pcomp="0.345654345654346" /psig="0.420579420579421" /xcortree=308 /SigmaFactorBS="atcttcatctgttacaacatacacggcttcaatttgtttgtc agGCTCATTTGATTTATgcttataatcctgcacctcataggaagcaagcaggcagctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2921823 /Source="Nicolas_upshifts" /id="U2501" /multdbtbs="-" /comp="M19" /sig="Sig-" /pcomp="0.345654345654346" /psig="0.420579420579421" /xcortree=308 /SigmaFactorBS="atcttcatctgttacaacatacacggcttcaatttgtttgtc agGCTCATTTGATTTATgcttataatcctgcacctcataggaagcaagcaggcagctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2922243..2922317) /Source="Nicolas_S_feature" /locus_tag="new_3297920_3297994_c" /HighExp="M40t90, Lbtran, LBGtran, Lbstat, C90, M0t90, T1.0H, LoTm, M40t45, BI" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1232" promotor_-35 2922265..2922272 /Source="Nicolas_upshift_promotors" /id="U2502" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.927072927072927" /psig="0.997002997002997" /xcortree=617 /SigmaFactorBS="ttgaaccgcataaaacatgaggcttacactcctaacgtaaTG GGTATTtgtaatgaacAATGGTATAATAGGAAAAACattctttccactatacttattt t" /listShort="S1233, yuiD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2922283..2922302 /Source="Nicolas_upshift_promotors" /id="U2502" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.927072927072927" /psig="0.997002997002997" /xcortree=617 /SigmaFactorBS="ttgaaccgcataaaacatgaggcttacactcctaacgtaaTG GGTATTtgtaatgaacAATGGTATAATAGGAAAAACattctttccactatacttattt t" /listShort="S1233, yuiD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2922285..2922399 /Source="Nicolas_S_feature" /locus_tag="new_3297962_3298076" /HighExp="Etha, Cold, Gly, Sw, LoTm, BC, B60, C90, dia5, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1233" upshifts 2922285 /Source="Nicolas_upshifts" /id="U2502" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.927072927072927" /psig="0.997002997002997" /xcortree=617 /SigmaFactorBS="ttgaaccgcataaaacatgaggcttacactcctaacgtaaTG GGTATTtgtaatgaacAATGGTATAATAGGAAAAACattctttccactatacttattt t" /listShort="S1233, yuiD" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(2922312..2922331) /Source="Nicolas_upshift_promotors" /id="U2503" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.601398601398601" /psig="0.999000999001" /xcortree=3139 /SigmaFactorBS="tttgaaaaatccttcgtgtttcaaaagaaaaaagcaagtctt agactgttgTTTGTTAAAATAAGTATAGTggaaagaatgtttttcctattataccatt g" /listShort="S1232, pepA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2922322) /Source="Nicolas_upshifts" /id="U2503" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.601398601398601" /psig="0.999000999001" /xcortree=3139 /SigmaFactorBS="tttgaaaaatccttcgtgtttcaaaagaaaaaagcaagtctt agactgttgTTTGTTAAAATAAGTATAGTggaaagaatgtttttcctattataccatt g" /listShort="S1232, pepA" /GFF_Attribute="listLong" /label="upshifts" CDS 2922400..2922876 /gene="yuiD" /locus_tag="BSU_32060" /old_locus_tag="BSU32060" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391086.1" /db_xref="EnsemblGenomes-Gn:BSU32060" /db_xref="EnsemblGenomes-Tr:CAB15196" /db_xref="GOA:O32107" /db_xref="InterPro:IPR003832" /db_xref="SubtiList:BG13969" /db_xref="UniProtKB/Swiss-Prot:O32107" /translation="MELLTNFPLLSSLAAIIFAQVIKVPIQFIVSRKLDWSLVTSTGG MPSSHSAAVTALSTGVALEHGLDSSLFAVSAIFAVITMFDATGVRRHAGEQATVINKL VIDFNRFVNEAKDFPKAAEKEKQKKLKELLGHQPIEVFFGGLTGILLTLVLAYFFM*" /label="yuiD CDS" gene 2922400..2922876 /gene="yuiD" /locus_tag="BSU_32060" /old_locus_tag="BSU32060" /label="yuiD gene" downshifts 2922825 /Source="Nicolas_upshifts" /id="D1657" /incds=0 /nref=18 /ntot=174 /MaxReadThrough="3.22946" /MaxDrop="3.90704" /score="10.9647804" /energy="-11.6" /TU="U2502" /idTUdmin="U2502" /TUdmin="-208" /isTUend="FALSE" /label="downshifts" CDS complement(2922907..2923563) /gene="spsC" /locus_tag="BSU_32070" /old_locus_tag="BSU32070" /experiment="publication(s) with functional evidences, PMID:26163297" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 26163297; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="stationary phase survival protein" /protein_id="NP_391087.1" /db_xref="EnsemblGenomes-Gn:BSU32070" /db_xref="EnsemblGenomes-Tr:CAB15197" /db_xref="GOA:O32108" /db_xref="InterPro:IPR010611" /db_xref="InterPro:IPR036908" /db_xref="PDB:4WJT" /db_xref="PDB:4WLI" /db_xref="PDB:4WLK" /db_xref="SubtiList:BG13968" /db_xref="UniProtKB/Swiss-Prot:O32108" /translation="MMLNMIRRLLMTCLFLLAFGTTFLSVSGIEAKDLSKWVQEHQEK HLKHAGLRLKALQQKQTQTTSAAEDKTKPLEEAFDWDEYPVQRVTATGYTAGAESTGK NPGDPLYGLTYSGVKVKRDLYSTVAADPSVFPIGTILFIPNYGLGVVADTGSAIKGNR LDLYFETVKDVYNEWGKKTLDVYVIKKGTGKITEDELEKLNETKSLQVFRNQYKTVKE *" /label="spsC CDS" gene complement(2922907..2923563) /gene="spsC" /locus_tag="BSU_32070" /old_locus_tag="BSU32070" /label="spsC gene" downshifts complement(2922935) /Source="Nicolas_upshifts" /id="D1658" /incds=0 /nref=178 /ntot=253 /MaxReadThrough="0.714039999999999" /MaxDrop="6.31907" /score="33.0538307" /energy="-12.6" /TU="NA" /idTUdmin="U2505" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 2923211..2923220 /Source="Nicolas_upshift_promotors" /id="U2504" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1331 /SigmaFactorBS="tggaatataaatcccgtttcACTTTCACACctgaatatgtaa gCCCGTATAATGGATCACCGGgatttttgcccgtcgactcagctcctgctgtgtagcc t" /listShort="S1234, S1235, S1236, S1237" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2923234..2923253 /Source="Nicolas_upshift_promotors" /id="U2504" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1331 /SigmaFactorBS="tggaatataaatcccgtttcACTTTCACACctgaatatgtaa gCCCGTATAATGGATCACCGGgatttttgcccgtcgactcagctcctgctgtgtagcc t" /listShort="S1234, S1235, S1236, S1237" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2923251 /Source="Nicolas_upshifts" /id="U2504" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1331 /SigmaFactorBS="tggaatataaatcccgtttcACTTTCACACctgaatatgtaa gCCCGTATAATGGATCACCGGgatttttgcccgtcgactcagctcctgctgtgtagcc t" /listShort="S1234, S1235, S1236, S1237" /GFF_Attribute="listLong" /label="upshifts" S_feature 2923253..2923699 /Source="Nicolas_S_feature" /locus_tag="new_3298930_3299376" /HighExp="S6, S8, S7, BT, B36, G/S, S5, Pyr, Cold, B60" /AntisenseName="yuiC" /AntisenseCor="0.52395204592174105" /AntisenseRegPval="-19.600000000000001" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1234" upshifts complement(2923577) /Source="Nicolas_upshifts" /id="U2505" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp="0.543456543456543" /psig="0.543456543456543" /xcortree=1022 /SigmaFactorBS="ttatgcgttcagctcattcaccatttTGAATAAtgctctctc cacttGGGAACAATGATtcggaggagaggtgaatgatgttgaatatgatcagacgttt g" /listShort="yuiC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2923579..2923590) /Source="Nicolas_upshift_promotors" /id="U2505" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp="0.543456543456543" /psig="0.543456543456543" /xcortree=1022 /SigmaFactorBS="ttatgcgttcagctcattcaccatttTGAATAAtgctctctc cacttGGGAACAATGATtcggaggagaggtgaatgatgttgaatatgatcagacgttt g" /listShort="yuiC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2923605..2923611) /Source="Nicolas_upshift_promotors" /id="U2505" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp="0.543456543456543" /psig="0.543456543456543" /xcortree=1022 /SigmaFactorBS="ttatgcgttcagctcattcaccatttTGAATAAtgctctctc cacttGGGAACAATGATtcggaggagaggtgaatgatgttgaatatgatcagacgttt g" /listShort="yuiC" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2923656 /Source="Nicolas_upshifts" /id="D1659" /incds=0 /nref=3 /ntot=11 /MaxReadThrough="7.61734" /MaxDrop="4.9382" /score="4.8726481" /energy="-7.9" /TU="U2504" /idTUdmin="U2506" /TUdmin="-323" /isTUend="FALSE" /label="downshifts" CDS complement(2923667..2923987) /gene="yuiB" /locus_tag="BSU_32080" /old_locus_tag="BSU32080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391088.1" /db_xref="EnsemblGenomes-Gn:BSU32080" /db_xref="EnsemblGenomes-Tr:CAB15198" /db_xref="GOA:O32109" /db_xref="InterPro:IPR025917" /db_xref="SubtiList:BG13967" /db_xref="UniProtKB/Swiss-Prot:O32109" /translation="MISLPVVIISIVLFFVLFFGIGFLLNMLLRMSWIMAVIYPIVCL FIISKEKLISYVQSPGESFASLFHRVLSLAAADVLILVSGLAGAIVSGIAINMLRKRG YQMF*" /label="yuiB CDS" gene complement(2923667..2923987) /gene="yuiB" /locus_tag="BSU_32080" /old_locus_tag="BSU32080" /label="yuiB gene" downshifts complement(2923681) /Source="Nicolas_upshifts" /id="D1660" /incds=0 /nref=151 /ntot=218 /MaxReadThrough="4.24535" /MaxDrop="5.6597" /score="13.4559443" /energy="-7.6" /TU="U2507,U2508" /idTUdmin="U2510" /TUdmin=660 /isTUend="FALSE" /label="downshifts" S_feature 2923701..2923911 /Source="Nicolas_S_feature" /locus_tag="new_3299378_3299588" /HighExp="S8, S6, S7, BT, Cold, Gly, H2O2, G/S, C30, G180" /AntisenseName="yuiB" /AntisenseCor="-0.11290507783715401" /AntisenseRegPval="-1.2" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1235" promotor_no_box 2923853..2923953 /Source="Nicolas_upshift_promotors" /id="U2506" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.641358641358641" /psig="0.02997002997003" /xcortree=280 /SigmaFactorBS="gaaaaggcatacaattggataaatcacagccataatccaaga cattctcagcagcatgtttaataagaaaccgattccaaaaaacaagacaaaaaacaaa a" /listShort="S1236" /GFF_Attribute="listLong" /label="promotor_no_box" S_feature 2923913..2924022 /Source="Nicolas_S_feature" /locus_tag="new_3299590_3299699" /HighExp="S8, S6, BT, S7, Sw, Gly, G180, BC, Diami, H2O2" /AntisenseName="yuiB" /AntisenseCor="-7.7565560595235006E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigK" /TUshortPSig="0.03, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1236" upshifts 2923913 /Source="Nicolas_upshifts" /id="U2506" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.641358641358641" /psig="0.02997002997003" /xcortree=280 /SigmaFactorBS="gaaaaggcatacaattggataaatcacagccataatccaaga cattctcagcagcatgtttaataagaaaccgattccaaaaaacaagacaaaaaacaaa a" /listShort="S1236" /GFF_Attribute="listLong" /label="upshifts" downshifts 2923979 /Source="Nicolas_upshifts" /id="D1661" /incds=0 /nref=10 /ntot=28 /MaxReadThrough="3.79664" /MaxDrop="6.06021" /score="4.8726481" /energy="-7.9" /TU="U2504" /idTUdmin="U2506" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2924006..2924025) /Source="Nicolas_upshift_promotors" /id="U2507" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.797202797202797" /psig="0.995004995004995" /xcortree=435 /SigmaFactorBS="aaaagacagtcattctttttccagCCGTTGACtttatttcag ccccCGCGTTACACTAAAAACAACgcaggggggtggaataggttgattagtctgccag t" /listShort="yuiB, yuiC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2924011) /Source="Nicolas_upshifts" /id="U2507" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.797202797202797" /psig="0.995004995004995" /xcortree=435 /SigmaFactorBS="aaaagacagtcattctttttccagCCGTTGACtttatttcag ccccCGCGTTACACTAAAAACAACgcaggggggtggaataggttgattagtctgccag t" /listShort="yuiB, yuiC" /GFF_Attribute="listLong" /label="upshifts" S_feature 2924024..2924575 /Source="Nicolas_S_feature" /locus_tag="new_3299701_3300252" /HighExp="S6, S8, S7, Cold, H2O2, BC, Sw, Pyr, BT, C30" /AntisenseName="yuiA" /AntisenseCor="5.87811391089679E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1237" promotor_-35 complement(2924040..2924047) /Source="Nicolas_upshift_promotors" /id="U2507" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.797202797202797" /psig="0.995004995004995" /xcortree=435 /SigmaFactorBS="aaaagacagtcattctttttccagCCGTTGACtttatttcag ccccCGCGTTACACTAAAAACAACgcaggggggtggaataggttgattagtctgccag t" /listShort="yuiB, yuiC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2924041..2924184) /gene="yuiA" /locus_tag="BSU_32090" /old_locus_tag="BSU32090" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391089.1" /db_xref="EnsemblGenomes-Gn:BSU32090" /db_xref="EnsemblGenomes-Tr:CAB15199" /db_xref="InterPro:IPR035272" /db_xref="InterPro:IPR036410" /db_xref="SubtiList:BG12389" /db_xref="UniProtKB/Swiss-Prot:O32110" /translation="MKTATTTASHACPFCSGKGYFQLILGGSETCPSCQGTGKDSHSF SSR*" /label="yuiA CDS" gene complement(2924041..2924184) /gene="yuiA" /locus_tag="BSU_32090" /old_locus_tag="BSU32090" /label="yuiA gene" promotor_-10 complement(2924208..2924227) /Source="Nicolas_upshift_promotors" /id="U2508" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.657342657342657" /psig="0.999000999001" /xcortree=2880 /SigmaFactorBS="gtatgtttccgcttacatcaaaagatttgtcacatgatctga cTTTAtTgttgacagcttgaTATGGTATATTATCAGAAAAttaagaaaaagggtgatg a" /listShort="yuiA, yuiB, yuiC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2924229) /Source="Nicolas_upshifts" /id="U2508" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.657342657342657" /psig="0.999000999001" /xcortree=2880 /SigmaFactorBS="gtatgtttccgcttacatcaaaagatttgtcacatgatctga cTTTAtTgttgacagcttgaTATGGTATATTATCAGAAAAttaagaaaaagggtgatg a" /listShort="yuiA, yuiB, yuiC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2924243..2924246) /Source="Nicolas_upshift_promotors" /id="U2508" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.657342657342657" /psig="0.999000999001" /xcortree=2880 /SigmaFactorBS="gtatgtttccgcttacatcaaaagatttgtcacatgatctga cTTTAtTgttgacagcttgaTATGGTATATTATCAGAAAAttaagaaaaagggtgatg a" /listShort="yuiA, yuiB, yuiC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2924357..2925577) /gene="yumB" /locus_tag="BSU_32100" /old_locus_tag="BSU32100" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15937154, 17015645, 26098117; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD-disulfide oxidoreductase" /protein_id="NP_391090.1" /db_xref="EnsemblGenomes-Gn:BSU32100" /db_xref="EnsemblGenomes-Tr:CAB15200" /db_xref="GOA:O05267" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG12390" /db_xref="UniProtKB/Swiss-Prot:O05267" /translation="MALNKPKIVILGAGYGGLMTVTRLTKYVGPNDADITLVNKHNYH YETTWMHEASAGTLHHDRCRYQIKDVINQSRVNFVQDTVKAIKIDEKKVVLANGELQY DYLVIGLGAVPETFGIKGLKEYAFPIANINTSRLLREHIELQFATYNTEAEKRPDRLT IVVGGAGFTGIEFLGELAARVPELCKEYDVDRSLVRIICVEAAPTVLPGFDPELVDYA VHYLEENGVEFKIGTAVQECTPEGVRVGKKDEEPEQIKSQTVVWAAGVRGHPIVEEAG FENMRGRVKVNPDLRAPGHDNVFILGDSSLFMNEDTERPYPPTAQIAMQQGITVAKNL GRLIKGGELEEFKPDIKGTVASLGEHNAVGVVYGRKLKGTPASFMKKVIDNRSLFMIG GLGLTLKKGKFKFF*" /label="yumB CDS" gene complement(2924357..2925577) /gene="yumB" /locus_tag="BSU_32100" /old_locus_tag="BSU32100" /label="yumB gene" downshifts complement(2924385) /Source="Nicolas_upshifts" /id="D1662" /incds=0 /nref=15 /ntot=123 /MaxReadThrough="3.19525" /MaxDrop="3.6794" /score="23.523765" /energy="-8.9" /TU="U2510" /idTUdmin="U2509" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2925578..2925705) /Source="Nicolas_S_feature" /locus_tag="new_3301255_3301382_c" /HighExp="Salt, S4, Etha, S5, S3, S7, S6, LoTm, B36, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.752, 0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1238" upshifts complement(2925705) /Source="Nicolas_upshifts" /id="U2509" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.752247752247752" /psig="0.752247752247752" /xcortree=1120 /SigmaFactorBS="aaatgaaatgatctttttcTGAATGtttcttgggccagccGG ATAAACATGATAATAGTgctacgggtaaggacttcacaaaaaacttttcaatatattt c" /listShort="S1238, yumB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2925707..2925771) /Source="Nicolas_S_feature" /locus_tag="new_3301384_3301448_c" /HighExp="Salt, Etha, Heat, BMM, BC, H2O2, Paraq, C30, Sw, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1239" promotor_-10 complement(2925707..2925725) /Source="Nicolas_upshift_promotors" /id="U2509" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.752247752247752" /psig="0.752247752247752" /xcortree=1120 /SigmaFactorBS="aaatgaaatgatctttttcTGAATGtttcttgggccagccGG ATAAACATGATAATAGTgctacgggtaaggacttcacaaaaaacttttcaatatattt c" /listShort="S1238, yumB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2925741..2925746) /Source="Nicolas_upshift_promotors" /id="U2509" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.752247752247752" /psig="0.752247752247752" /xcortree=1120 /SigmaFactorBS="aaatgaaatgatctttttcTGAATGtttcttgggccagccGG ATAAACATGATAATAGTgctacgggtaaggacttcacaaaaaacttttcaatatattt c" /listShort="S1238, yumB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2925762..2925781) /Source="Nicolas_upshift_promotors" /id="U2510" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.460539460539461" /psig="0.993006993006993" /xcortree=671 /SigmaFactorBS="tcgtaaggatctaacgtgcccatccgtTCTTGAAAatatttc cgcaggcCGCTACGATAATAACCAAATgaaatgatctttttctgaatgtttcttgggc c" /listShort="S1239, S1238, yumB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2925770) /Source="Nicolas_upshifts" /id="U2510" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.460539460539461" /psig="0.993006993006993" /xcortree=671 /SigmaFactorBS="tcgtaaggatctaacgtgcccatccgtTCTTGAAAatatttc cgcaggcCGCTACGATAATAACCAAATgaaatgatctttttctgaatgtttcttgggc c" /listShort="S1239, S1238, yumB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2925796..2925803) /Source="Nicolas_upshift_promotors" /id="U2510" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.460539460539461" /psig="0.993006993006993" /xcortree=671 /SigmaFactorBS="tcgtaaggatctaacgtgcccatccgtTCTTGAAAatatttc cgcaggcCGCTACGATAATAACCAAATgaaatgatctttttctgaatgtttcttgggc c" /listShort="S1239, S1238, yumB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2925845..2925852 /Source="Nicolas_upshift_promotors" /id="U2511" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.847152847152847" /psig=1 /xcortree=2382 /SigmaFactorBS="acggatgggcacgttagatccttacgattttttctgctgacT CGTCAATttgaacggcaaTATGGTATAATTAATAACAAttttcatttaggaggcaatt t" /listShort="yumC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2925864..2925883 /Source="Nicolas_upshift_promotors" /id="U2511" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.847152847152847" /psig=1 /xcortree=2382 /SigmaFactorBS="acggatgggcacgttagatccttacgattttttctgctgacT CGTCAATttgaacggcaaTATGGTATAATTAATAACAAttttcatttaggaggcaatt t" /listShort="yumC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2925864 /Source="Nicolas_upshifts" /id="U2511" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.847152847152847" /psig=1 /xcortree=2382 /SigmaFactorBS="acggatgggcacgttagatccttacgattttttctgctgacT CGTCAATttgaacggcaaTATGGTATAATTAATAACAAttttcatttaggaggcaatt t" /listShort="yumC" /GFF_Attribute="listLong" /label="upshifts" CDS 2925909..2926907 /gene="trxBB" /locus_tag="BSU_32110" /old_locus_tag="BSU32110" /EC_number="1.18.1.2" /function="16.2: Construct biomass (Anabolism)" /function="16.7: Manage energy" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:15252706, 22938038, 26507228, 26965753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15252706, 22938038, 26507228, 26965753; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ferredoxin-NADP+ reductase (flavodoxin)" /protein_id="NP_391091.2" /db_xref="EnsemblGenomes-Gn:BSU32110" /db_xref="EnsemblGenomes-Tr:CAB15201" /db_xref="GOA:O05268" /db_xref="InterPro:IPR000103" /db_xref="InterPro:IPR022890" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="PDB:3LZW" /db_xref="PDB:3LZX" /db_xref="SubtiList:BG12391" /db_xref="UniProtKB/Swiss-Prot:O05268" /translation="MREDTKVYDITIIGGGPVGLFTAFYGGMRQASVKIIESLPQLGG QLSALYPEKYIYDVAGFPKIRAQELINNLKEQMAKFDQTICLEQAVESVEKQADGVFK LVTNEETHYSKTVIITAGNGAFKPRKLELENAEQYEGKNLHYFVDDLQKFAGRRVAIL GGGDSAVDWALMLEPIAKEVSIIHRRDKFRAHEHSVENLHASKVNVLTPFVPAELIGE DKIEQLVLEEVKGDRKEILEIDDLIVNYGFVSSLGPIKNWGLDIEKNSIVVKSTMETN IEGFFAAGDICTYEGKVNLIASGFGEAPTAVNNAKAYMDPKARVQPLHSTSLFENK*" /label="trxBB CDS" gene 2925909..2926907 /gene="trxBB" /locus_tag="BSU_32110" /old_locus_tag="BSU32110" /label="trxBB gene" promotor_-10 complement(2925932..2925950) /Source="Nicolas_upshift_promotors" /id="U2512" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1201 /SigmaFactorBS="gacgcttgcctgtctcatcccgccgtaaaaagcggTGAATAa gccgaccggtcccccGCCTATAATTGTAATATCAtaaacctttgtatcctctcgcata c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2925947) /Source="Nicolas_upshifts" /id="U2512" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1201 /SigmaFactorBS="gacgcttgcctgtctcatcccgccgtaaaaagcggTGAATAa gccgaccggtcccccGCCTATAATTGTAATATCAtaaacctttgtatcctctcgcata c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2925967..2925972) /Source="Nicolas_upshift_promotors" /id="U2512" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1201 /SigmaFactorBS="gacgcttgcctgtctcatcccgccgtaaaaagcggTGAATAa gccgaccggtcccccGCCTATAATTGTAATATCAtaaacctttgtatcctctcgcata c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2926883 /Source="Nicolas_upshifts" /id="D1663" /incds=0 /nref=162 /ntot=262 /MaxReadThrough="0.70088" /MaxDrop="7.47867" /score="21.6819221" /energy="-12.8" /TU="U2511" /idTUdmin="U2511" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(2926946..2927086) /gene="yuzG" /locus_tag="BSU_32120" /old_locus_tag="BSU32120" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein or unknown function" /protein_id="NP_391092.1" /db_xref="EnsemblGenomes-Gn:BSU32120" /db_xref="EnsemblGenomes-Tr:CAB15202" /db_xref="GOA:O32111" /db_xref="SubtiList:BG14056" /db_xref="UniProtKB/Swiss-Prot:O32111" /translation="MAQNEEKTPKSQKIQDRIIMAMIWVVAALVIALVVGTALNYINI FK*" /label="yuzG CDS" gene complement(2926946..2927086) /gene="yuzG" /locus_tag="BSU_32120" /old_locus_tag="BSU32120" /label="yuzG gene" downshifts complement(2926958) /Source="Nicolas_upshifts" /id="D1664" /incds=0 /nref=61 /ntot=234 /MaxReadThrough="1.27572" /MaxDrop="5.65243" /score="32.0354025" /energy="-12.8" /TU="NA" /idTUdmin="U2515" /TUdmin=1 /isTUend="TRUE" /label="downshifts" S_feature complement(2927087..2927216) /Source="Nicolas_S_feature" /locus_tag="new_3302764_3302893_c" /HighExp="dia15, Salt, Cold, Diami, H2O2, Etha, GM 15, dia5, MG-0.2, MG t5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.36371900000000001" /TUshortSig="SigA, SigGF" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1240" promotor_-10 complement(2927197..2927216) /Source="Nicolas_upshift_promotors" /id="U2513" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.344655344655345" /psig="0.999000999001" /xcortree=1851 /SigmaFactorBS="aacattatgatttgctggcaggtgtggtgcaagtgccgaaGC TTGTCatgcagggtgagtTTAGGTATCATAGTTTTAACgaatggtcttagagagcgga t" /listShort="S1240, yuzG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2927216) /Source="Nicolas_upshifts" /id="U2513" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.344655344655345" /psig="0.999000999001" /xcortree=1851 /SigmaFactorBS="aacattatgatttgctggcaggtgtggtgcaagtgccgaaGC TTGTCatgcagggtgagtTTAGGTATCATAGTTTTAACgaatggtcttagagagcgga t" /listShort="S1240, yuzG" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2927218..2927465) /Source="Nicolas_S_feature" /locus_tag="new_3302895_3303142_c" /HighExp="S8, S5, S6, S7, S4, ferm, nit, C30, Pyr, T5.0H" /AntisenseName="guaC" /AntisenseCor="-0.291283195124732" /AntisenseRegPval="-5.9" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1241" promotor_-35 complement(2927230..2927236) /Source="Nicolas_upshift_promotors" /id="U2513" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.344655344655345" /psig="0.999000999001" /xcortree=1851 /SigmaFactorBS="aacattatgatttgctggcaggtgtggtgcaagtgccgaaGC TTGTCatgcagggtgagtTTAGGTATCATAGTTTTAACgaatggtcttagagagcgga t" /listShort="S1240, yuzG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2927273..2927280 /Source="Nicolas_upshift_promotors" /id="U2514" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.518481518481518" /psig="0.998001998001998" /xcortree=2630 /SigmaFactorBS="cacttgcaccacacctgccagcaaatcataaTGTTTGACatc ctaaataaaaCAGAGTACATTATATAAGGCgaacatttcatatattatacttttaaat a" /listShort="guaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2927294..2927313 /Source="Nicolas_upshift_promotors" /id="U2514" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.518481518481518" /psig="0.998001998001998" /xcortree=2630 /SigmaFactorBS="cacttgcaccacacctgccagcaaatcataaTGTTTGACatc ctaaataaaaCAGAGTACATTATATAAGGCgaacatttcatatattatacttttaaat a" /listShort="guaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2927302 /Source="Nicolas_upshifts" /id="U2514" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.518481518481518" /psig="0.998001998001998" /xcortree=2630 /SigmaFactorBS="cacttgcaccacacctgccagcaaatcataaTGTTTGACatc ctaaataaaaCAGAGTACATTATATAAGGCgaacatttcatatattatacttttaaat a" /listShort="guaC" /GFF_Attribute="listLong" /label="upshifts" CDS 2927365..2928345 /gene="guaC" /locus_tag="BSU_32130" /old_locus_tag="BSU32130" /EC_number="1.7.1.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6408059, 11591660, 6408059" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6408059, 11591660, 6408059; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GMP reductase (NADP-dependent)" /protein_id="NP_391093.2" /db_xref="EnsemblGenomes-Gn:BSU32130" /db_xref="EnsemblGenomes-Tr:CAB15203" /db_xref="GOA:O05269" /db_xref="InterPro:IPR001093" /db_xref="InterPro:IPR005994" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR015875" /db_xref="SubtiList:BG12392" /db_xref="UniProtKB/Swiss-Prot:O05269" /translation="MENVFDYEDIQLIPAKCIVNSRSECDTSVRLGGHTFKLPVVPAN MQTIIDEKLAISLAENGYFYVMHRFEPETRIDFIKDMNARGLFSSISVGVKDEEYEFV RQLAEENLTPEYVTIDIAHGHSNAVIEMIQHLKKHLPDSFVIAGNVGTPEAVRELENA GADATKVGIGPGKVCITKIKTGFGTGGWQLAALRWCAKAASKPIIADGGIRTHGDIAK SIRFGATMVMIGSLFAGHEESPGQTIEKDGKLYKEYFGSASEFQKGEKKNVEGKKMHV AHKGSIKDTLIEMEQDLQSSISYAGGTKLNAIRNVDYVIVKNSIFNGDKY*" /label="guaC CDS" gene 2927365..2928345 /gene="guaC" /locus_tag="BSU_32130" /old_locus_tag="BSU32130" /label="guaC gene" upshifts complement(2927466) /Source="Nicolas_upshifts" /id="U2515" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=853 /SigmaFactorBS="cgctagtttttcatctataatcgtcTGCATATtggcagggac gacGGGCAATTTAAAtgtatgtccgcctaaacgtacggatgtatcacattctgaacgg c" /listShort="S1241, S1240, yuzG" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2927470..2927481) /Source="Nicolas_upshift_promotors" /id="U2515" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=853 /SigmaFactorBS="cgctagtttttcatctataatcgtcTGCATATtggcagggac gacGGGCAATTTAAAtgtatgtccgcctaaacgtacggatgtatcacattctgaacgg c" /listShort="S1241, S1240, yuzG" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2927495..2927501) /Source="Nicolas_upshift_promotors" /id="U2515" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=853 /SigmaFactorBS="cgctagtttttcatctataatcgtcTGCATATtggcagggac gacGGGCAATTTAAAtgtatgtccgcctaaacgtacggatgtatcacattctgaacgg c" /listShort="S1241, S1240, yuzG" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2928313 /Source="Nicolas_upshifts" /id="D1665" /incds=0 /nref=91 /ntot=186 /MaxReadThrough="1.24882" /MaxDrop="7.43286" /score="-2.82053244" /energy="-16.2" /TU="NA" /idTUdmin="U2514" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2928418) /Source="Nicolas_upshifts" /id="D1666" /incds=0 /nref=24 /ntot=212 /MaxReadThrough="1.15696" /MaxDrop="6.12198" /score="23.834956" /energy="-16.2" /TU="NA" /idTUdmin="U2517" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(2928419..2929042) /gene="paiB" /locus_tag="BSU_32140" /old_locus_tag="BSU32140" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 16210326, 21633969; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="transcriptional regulator (regulates paiA expression)" /protein_id="NP_391094.2" /db_xref="EnsemblGenomes-Gn:BSU32140" /db_xref="EnsemblGenomes-Tr:CAB15204" /db_xref="GOA:P21341" /db_xref="InterPro:IPR007396" /db_xref="InterPro:IPR012349" /db_xref="SubtiList:BG10696" /db_xref="UniProtKB/Swiss-Prot:P21341" /translation="MYIPKYFKVTNAEEIWNFVQENSFGTVVTTEQGKPIATHLPLGF NKKDDHYYITGHFAYGNPQWRTFEACEDVLVMFQGPHAYISSSWYSRENVPTWNYQAV HMYGKASMLEKDELAEELTIMLEKYEKHRDNPVLWDKLSPKLLESELKGIVGFKIKVE DIQAAYKLSQNRNETDYMNVIEQLQNEENPNAKQMAELMEDKLKKQI*" /label="paiB CDS" gene complement(2928419..2929042) /gene="paiB" /locus_tag="BSU_32140" /old_locus_tag="BSU32140" /label="paiB gene" CDS complement(2929066..2929584) /gene="paiA" /locus_tag="BSU_32150" /old_locus_tag="BSU32150" /EC_number="2.3.1.57" /function="16.6: Maintain" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16210326, 17588214, 21633970, 26818562, 28546427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16210326, 17588214, 21633970, 26818562, 28546427; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="polyamine N-acetyltransferase" /protein_id="NP_391095.1" /db_xref="EnsemblGenomes-Gn:BSU32150" /db_xref="EnsemblGenomes-Tr:CAB15205" /db_xref="GOA:P21340" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="PDB:1TIQ" /db_xref="SubtiList:BG10695" /db_xref="UniProtKB/Swiss-Prot:P21340" /translation="MSVKMKKCSREDLQTLQQLSIETFNDTFKEQNSPENMKAYLESA FNTEQLEKELSNMSSQFFFIYFDHEIAGYVKVNIDDAQSEEMGAESLEIERIYIKNSF QKHGLGKHLLNKAIEIALERNKKNIWLGVWEKNENAIAFYKKMGFVQTGAHSFYMGDE EQTDLIMAKTLI*" /label="paiA CDS" gene complement(2929066..2929584) /gene="paiA" /locus_tag="BSU_32150" /old_locus_tag="BSU32150" /label="paiA gene" misc_feature complement(2929631..2929650) /Source="Nicolas_upshift_promotors" /id="U2516" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.719280719280719" /psig="0.937062937062937" /xcortree=2765 /SigmaFactorBS="ggagttggtgatgaagaagatttttggaatggtaacaaggtc agtatgtgttcCGTGTTTAAATATATAAAAGggacacaagacaattgaattttaaata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2929643) /Source="Nicolas_upshifts" /id="U2516" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.719280719280719" /psig="0.937062937062937" /xcortree=2765 /SigmaFactorBS="ggagttggtgatgaagaagatttttggaatggtaacaaggtc agtatgtgttcCGTGTTTAAATATATAAAAGggacacaagacaattgaattttaaata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2929645..2929753) /Source="Nicolas_S_feature" /locus_tag="new_3305322_3305430_c" /HighExp="LoTm, HiTm, G135, Salt, G180, Cold, LBGstat, T0.0H, B36, T-2.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1242" promotor_-10 complement(2929740..2929757) /Source="Nicolas_upshift_promotors" /id="U2517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.698301698301698" /psig=1 /xcortree=1782 /SigmaFactorBS="gcaagagaaacgctgctttgttgtttgattttTGTTGTAAat acagcaaagttaCGATATATTTAATGCGGAgtatattttattgcatttacaacaaaat c" /listShort="S1242, paiA, paiB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2929751) /Source="Nicolas_upshifts" /id="U2517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.698301698301698" /psig=1 /xcortree=1782 /SigmaFactorBS="gcaagagaaacgctgctttgttgtttgattttTGTTGTAAat acagcaaagttaCGATATATTTAATGCGGAgtatattttattgcatttacaacaaaat c" /listShort="S1242, paiA, paiB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2929772..2929779) /Source="Nicolas_upshift_promotors" /id="U2517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.698301698301698" /psig=1 /xcortree=1782 /SigmaFactorBS="gcaagagaaacgctgctttgttgtttgattttTGTTGTAAat acagcaaagttaCGATATATTTAATGCGGAgtatattttattgcatttacaacaaaat c" /listShort="S1242, paiA, paiB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2929907) /Source="Nicolas_upshifts" /id="D1667" /incds=0 /nref=267 /ntot=269 /MaxReadThrough="1.56881" /MaxDrop="8.24828" /score="12.6937405" /energy="-18.7" /TU="NA" /idTUdmin="U2518" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2929922..2930284) /gene="sufA" /locus_tag="BSU_32160" /old_locus_tag="BSU32160" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17698959, 19478995, 20097860, 25447545; Product type c: carrier" /codon_start=1 /transl_table=11 /product="sulfur carrier chaperone involved in Fe-S cluster assembly" /protein_id="NP_391096.1" /db_xref="EnsemblGenomes-Gn:BSU32160" /db_xref="EnsemblGenomes-Tr:CAB15206" /db_xref="GOA:O32113" /db_xref="InterPro:IPR000361" /db_xref="InterPro:IPR016092" /db_xref="InterPro:IPR017870" /db_xref="InterPro:IPR035903" /db_xref="SubtiList:BG14049" /db_xref="UniProtKB/Swiss-Prot:O32113" /translation="MSNPVTITEAAALHIKDMMKEHEEENAFLRVGVKGGGCSGLSYG MGFEHEKSESDSVFDQHGITVLVDKESLDIMNGTVIDYKQSMLGGGFTIDNPNAIASC GCGSSFRTATNAGKPEEC*" /label="sufA CDS" gene complement(2929922..2930284) /gene="sufA" /locus_tag="BSU_32160" /old_locus_tag="BSU32160" /label="sufA gene" promotor_-10 complement(2930315..2930334) /Source="Nicolas_upshift_promotors" /id="U2518" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.765234765234765" /psig=1 /xcortree=2038 /SigmaFactorBS="gtgagggtgtctatttcttgtaaaacacctTGTTTGAGaatt ggaacgatcATGTTTATAATAAAAGACAGcaaccggtttttaaaaggaggttcataat g" /listShort="yutM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2930325) /Source="Nicolas_upshifts" /id="U2518" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.765234765234765" /psig=1 /xcortree=2038 /SigmaFactorBS="gtgagggtgtctatttcttgtaaaacacctTGTTTGAGaatt ggaacgatcATGTTTATAATAAAAGACAGcaaccggtttttaaaaggaggttcataat g" /listShort="yutM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2930348..2930355) /Source="Nicolas_upshift_promotors" /id="U2518" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.765234765234765" /psig=1 /xcortree=2038 /SigmaFactorBS="gtgagggtgtctatttcttgtaaaacacctTGTTTGAGaatt ggaacgatcATGTTTATAATAAAAGACAGcaaccggtttttaaaaggaggttcataat g" /listShort="yutM" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2930363..2931217) /gene="dapF" /locus_tag="BSU_32170" /old_locus_tag="BSU32170" /EC_number="5.1.1.7" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 14627808, 16723397, 19307721, 28873470; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="diaminopimelate epimerase" /protein_id="NP_391097.1" /db_xref="EnsemblGenomes-Gn:BSU32170" /db_xref="EnsemblGenomes-Tr:CAB15207" /db_xref="GOA:O32114" /db_xref="InterPro:IPR001653" /db_xref="InterPro:IPR018510" /db_xref="SubtiList:BG14048" /db_xref="UniProtKB/Swiss-Prot:O32114" /translation="MNSFRFTKMHGLGNSYIYVNQFEEQLPEEKLSEIAIQVSSVYTG IGSDGMILICPSDQAPVKMRIFNNDGSEGKNCGNGLRCVAKYAYEHKLVEETSFLIET LSGLVKAEVQVENGKVNVVTVDMGEPRLTKSELPMLDGGEEHTINETMAFGEVELTGT AVSMGNPHIVFPIADIEQAPLTTLGPVIEKDPRFPEGINVEFVETVNEQELHFRVWER GSGITQACGTGACAAAVASVLNGVSKRNQDITVHLAGGDLVINWKDNGHVMMTGPAET VCEGVYFL*" /label="dapF CDS" gene complement(2930363..2931217) /gene="dapF" /locus_tag="BSU_32170" /old_locus_tag="BSU32170" /label="dapF gene" promotor_-10 complement(2930933..2930952) /Source="Nicolas_upshift_promotors" /id="U2519" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1232 /SigmaFactorBS="gggaaaaactgcggcaacggcctgcgcTGCGTCGCAAaatac gcatatgAGCATAAGCTGGTTGAGGAAacatcttttctgattgaaactctctccgggc t" /listShort="yutM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2930941) /Source="Nicolas_upshifts" /id="U2519" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1232 /SigmaFactorBS="gggaaaaactgcggcaacggcctgcgcTGCGTCGCAAaatac gcatatgAGCATAAGCTGGTTGAGGAAacatcttttctgattgaaactctctccgggc t" /listShort="yutM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2930965..2930974) /Source="Nicolas_upshift_promotors" /id="U2519" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1232 /SigmaFactorBS="gggaaaaactgcggcaacggcctgcgcTGCGTCGCAAaatac gcatatgAGCATAAGCTGGTTGAGGAAacatcttttctgattgaaactctctccgggc t" /listShort="yutM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2931239..2931258) /Source="Nicolas_upshift_promotors" /id="U2520" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.843156843156843" /psig="0.999000999001" /xcortree=2385 /SigmaFactorBS="aaggagcttttatgtatgaaaaacgggggataattgtATTGt gtccgcttataatAGCTTTTATACTAAGAAAAAgaaaaaaagttggaggcacctatga a" /listShort="dapF, yutM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2931253) /Source="Nicolas_upshifts" /id="U2520" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.843156843156843" /psig="0.999000999001" /xcortree=2385 /SigmaFactorBS="aaggagcttttatgtatgaaaaacgggggataattgtATTGt gtccgcttataatAGCTTTTATACTAAGAAAAAgaaaaaaagttggaggcacctatga a" /listShort="dapF, yutM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2931273..2931276) /Source="Nicolas_upshift_promotors" /id="U2520" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.843156843156843" /psig="0.999000999001" /xcortree=2385 /SigmaFactorBS="aaggagcttttatgtatgaaaaacgggggataattgtATTGt gtccgcttataatAGCTTTTATACTAAGAAAAAgaaaaaaagttggaggcacctatga a" /listShort="dapF, yutM" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2931340..2932554) /gene="yutK" /locus_tag="BSU_32180" /old_locus_tag="BSU32180" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na+(H+)/nucleoside cotransporter" /protein_id="NP_391098.1" /db_xref="EnsemblGenomes-Gn:BSU32180" /db_xref="EnsemblGenomes-Tr:CAB15208" /db_xref="GOA:O32115" /db_xref="InterPro:IPR002668" /db_xref="InterPro:IPR008276" /db_xref="InterPro:IPR011657" /db_xref="InterPro:IPR018270" /db_xref="SubtiList:BG14047" /db_xref="UniProtKB/Swiss-Prot:O32115" /translation="MNVLWGLLGAVAIIAIAFLFSEKKSNIKIRTVIVGLCTQVAFGY IVLKWEAGRAVFLWFSSRVQLLIDYANEGISFIFGPLLKVGDSPAFALSVLPVIIFFS ALIAVLYHLKIMQLVFRVIGGGLSKLLGTSKTESLAAAANIFVGQSESPLVIKPLIAG LTRSELFTIMTSGLSAVAGSTLFGYALLGIPIEYLLAASFMAAPAGLVFGKLIIPETE KTQTVKSDFKMDEGEGAANVIDAAAKGASTGLQIALNVGAMLLAFVALIAVVNGILGG AFGLFGLKGVTLESILGYVFSPIAFLIGVPWHEALQAGSYIGQKLVLNEFVAYSNFGS HIGEFSKKTATIISFALCGFANFSSIAIMLGTLGGLAPSRRSDIARLGLKAVLAGTLA NLLSAAIAGMFI*" /label="yutK CDS" gene complement(2931340..2932554) /gene="yutK" /locus_tag="BSU_32180" /old_locus_tag="BSU32180" /label="yutK gene" promotor_-35 2931889..2931895 /Source="Nicolas_upshift_promotors" /id="U2521" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=205 /SigmaFactorBS="tcgccttcatccattttgaaatcgctttttacGGTTTGCgtt ttttccgtttcGGGTATAATCAATTTACCAaagactagtccagctggagcagccataa a" /listShort="S1243, S1244, yutJ" /listLong="yutI" /label="promotor_-35" promotor_-10 2931910..2931928 /Source="Nicolas_upshift_promotors" /id="U2521" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=205 /SigmaFactorBS="tcgccttcatccattttgaaatcgctttttacGGTTTGCgtt ttttccgtttcGGGTATAATCAATTTACCAaagactagtccagctggagcagccataa a" /listShort="S1243, S1244, yutJ" /listLong="yutI" /label="promotor_-10" upshifts 2931917 /Source="Nicolas_upshifts" /id="U2521" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=205 /SigmaFactorBS="tcgccttcatccattttgaaatcgctttttacGGTTTGCgtt ttttccgtttcGGGTATAATCAATTTACCAaagactagtccagctggagcagccataa a" /listShort="S1243, S1244, yutJ" /listLong="yutI" /label="upshifts" S_feature 2931921..2932690 /Source="Nicolas_S_feature" /locus_tag="new_3307598_3308367" /HighExp="Etha, Salt, Gly, M9-stat, Sw, LoTm, B60, BC, Heat, S0" /AntisenseName="yutK" /AntisenseCor="-0.36240965013078302" /AntisenseRegPval="-9" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1243" promotor_-10 complement(2932591..2932610) /Source="Nicolas_upshift_promotors" /id="U2522" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.924075924075924" /psig="0.998001998001998" /xcortree=2478 /SigmaFactorBS="ccgtacaaaagaactaaaaaaatgTGTAGACAtcaaaaaata ttatTGTTATCGTATAAAAGATATttttttaaataaaatttaagaggtgtacgagtat t" /listShort="yutK" /listLong="dapF, yutM" /label="promotor_-10" upshifts complement(2932596) /Source="Nicolas_upshifts" /id="U2522" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.924075924075924" /psig="0.998001998001998" /xcortree=2478 /SigmaFactorBS="ccgtacaaaagaactaaaaaaatgTGTAGACAtcaaaaaata ttatTGTTATCGTATAAAAGATATttttttaaataaaatttaagaggtgtacgagtat t" /listShort="yutK" /listLong="dapF, yutM" /label="upshifts" promotor_-35 complement(2932625..2932632) /Source="Nicolas_upshift_promotors" /id="U2522" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.924075924075924" /psig="0.998001998001998" /xcortree=2478 /SigmaFactorBS="ccgtacaaaagaactaaaaaaatgTGTAGACAtcaaaaaata ttatTGTTATCGTATAAAAGATATttttttaaataaaatttaagaggtgtacgagtat t" /listShort="yutK" /listLong="dapF, yutM" /label="promotor_-35" downshifts 2932647 /Source="Nicolas_upshifts" /id="D1668" /incds=0 /nref=3 /ntot=58 /MaxReadThrough="4.13852" /MaxDrop="3.94079" /score="20.5760616" /energy="-10.5" /TU="U2521" /idTUdmin="U2521" /TUdmin="-1913" /isTUend="FALSE" /label="downshifts" CDS complement(2932691..2932927) /gene="yuzB" /locus_tag="BSU_32190" /old_locus_tag="BSU32190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391099.1" /db_xref="EnsemblGenomes-Gn:BSU32190" /db_xref="EnsemblGenomes-Tr:CAB15209" /db_xref="InterPro:IPR009910" /db_xref="InterPro:IPR022916" /db_xref="SubtiList:BG14051" /db_xref="UniProtKB/Swiss-Prot:O32116" /translation="MNPMIEFCVSNLAHGSQEARAILEKDPNLDVLEYGCLSYCGTCM ESLFALVNGEVVMGETPAELVENIYTFIEENPMF*" /label="yuzB CDS" gene complement(2932691..2932927) /gene="yuzB" /locus_tag="BSU_32190" /old_locus_tag="BSU32190" /label="yuzB gene" S_feature 2932692..2933108 /Source="Nicolas_S_feature" /locus_tag="new_3308369_3308785" /HighExp="Salt, LoTm, Gly, Etha, Sw, Heat, S0, C30, M9-stat, Mal" /AntisenseName="yuzB" /AntisenseCor="-5.6824456709843603E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1244" downshifts complement(2932709) /Source="Nicolas_upshifts" /id="D1669" /incds=0 /nref=175 /ntot=239 /MaxReadThrough="1.28789" /MaxDrop="7.32368" /score="41.4640292" /energy="-10.5" /TU="NA" /idTUdmin="U2523" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2932892..2932893) /Source="Nicolas_upshift_promotors" /id="U2523" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.276723276723277" /psig="0.122877122877123" /xcortree=3156 /SigmaFactorBS="cgcgataatggacatatgtgaggtgaaaccgcatgaatccaa tgattgaattttgtgtCAGCAatcTGgctcacggctctcaggaagcccgggcgatttt g" /listShort="yuzB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2932897..2932901) /Source="Nicolas_upshift_promotors" /id="U2523" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.276723276723277" /psig="0.122877122877123" /xcortree=3156 /SigmaFactorBS="cgcgataatggacatatgtgaggtgaaaccgcatgaatccaa tgattgaattttgtgtCAGCAatcTGgctcacggctctcaggaagcccgggcgatttt g" /listShort="yuzB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2932899) /Source="Nicolas_upshifts" /id="U2523" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.276723276723277" /psig="0.122877122877123" /xcortree=3156 /SigmaFactorBS="cgcgataatggacatatgtgaggtgaaaccgcatgaatccaa tgattgaattttgtgtCAGCAatcTGgctcacggctctcaggaagcccgggcgatttt g" /listShort="yuzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2932942..2932961) /Source="Nicolas_upshift_promotors" /id="U2524" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2043 /SigmaFactorBS="taaattttgaatcatccgttgTCTTTGACgaatagtgaaaaa TTCGCGATAATGGACATATGtgaggtgaaaccgcatgaatccaatgattgaattttgt g" /listShort="yuzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2932943) /Source="Nicolas_upshifts" /id="U2524" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2043 /SigmaFactorBS="taaattttgaatcatccgttgTCTTTGACgaatagtgaaaaa TTCGCGATAATGGACATATGtgaggtgaaaccgcatgaatccaatgattgaattttgt g" /listShort="yuzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2932975..2932982) /Source="Nicolas_upshift_promotors" /id="U2524" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2043 /SigmaFactorBS="taaattttgaatcatccgttgTCTTTGACgaatagtgaaaaa TTCGCGATAATGGACATATGtgaggtgaaaccgcatgaatccaatgattgaattttgt g" /listShort="yuzB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2933085..2933090 /Source="Nicolas_upshift_promotors" /id="U2525" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.35964035964036" /psig=1 /xcortree=2314 /SigmaFactorBS="tttcaggctaaattgtaggttattttgaaactattATTGTGa ttttagatcaaaTTCGATATAATTCTAGATGTtattttacatagttcgtattttcttc a" /listShort="yutJ" /listLong="yutI" /label="promotor_-35" promotor_-10 2933104..2933123 /Source="Nicolas_upshift_promotors" /id="U2525" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.35964035964036" /psig=1 /xcortree=2314 /SigmaFactorBS="tttcaggctaaattgtaggttattttgaaactattATTGTGa ttttagatcaaaTTCGATATAATTCTAGATGTtattttacatagttcgtattttcttc a" /listShort="yutJ" /listLong="yutI" /label="promotor_-10" upshifts 2933110 /Source="Nicolas_upshifts" /id="U2525" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.35964035964036" /psig=1 /xcortree=2314 /SigmaFactorBS="tttcaggctaaattgtaggttattttgaaactattATTGTGa ttttagatcaaaTTCGATATAATTCTAGATGTtattttacatagttcgtattttcttc a" /listShort="yutJ" /listLong="yutI" /label="upshifts" CDS 2933190..2934257 /gene="yutJ" /locus_tag="BSU_32200" /old_locus_tag="BSU32200" /EC_number="1.6.-.-" /function="16.10: Respire" /function="16.7: Manage energy" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17015645; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NADH dehydrogenase" /protein_id="NP_391100.2" /db_xref="EnsemblGenomes-Gn:BSU32200" /db_xref="EnsemblGenomes-Tr:CAB15210" /db_xref="GOA:O32117" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG14046" /db_xref="UniProtKB/Swiss-Prot:O32117" /translation="MKKLVLIGGGYGNMRVLHRLLPNQLPDDVSITLIDRNPYHCLKT EYYALAAGTISDHHIRVSFPEHPRLDVQYGDITSIDIVQKQVLFQDREPISYDDAIIG LGCEDKYHNVPGAPEFTYSIQTIDQSRETYQKLNNLSANATVAIVGAGLSGVELASEL RESRDDLNIILFDRGNLILSSFPERLSKYVQKWFEEHGVRIINRANITKVEEGVVYNH DDPISADAIVWTAGIQPNKVVRDLDVEKDAQGRIVLTPHHNLPGDEHLYVVGDCASLP HAPSAQLAEAQAEQIVQILQKRWNGEALPESMPQFKLKGVLGSLGKKAGFGLVADRPL IGRVPRMLKSGLLWMYKHHNG*" /label="yutJ CDS" gene 2933190..2934257 /gene="yutJ" /locus_tag="BSU_32200" /old_locus_tag="BSU32200" /label="yutJ gene" downshifts 2934241 /Source="Nicolas_upshifts" /id="D1670" /incds=0 /nref=4 /ntot=110 /MaxReadThrough="3.51945" /MaxDrop="3.02708" /score="6.15657679" /energy="-10.8" /TU="U2521,U2525" /idTUdmin="U2521" /TUdmin="-319" /isTUend="FALSE" /label="downshifts" CDS complement(2934283..2934609) /gene="yuzD" /locus_tag="BSU_32210" /old_locus_tag="BSU32210" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11551182; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sulfur oxido-reduction management enzyme" /protein_id="NP_391101.1" /db_xref="EnsemblGenomes-Gn:BSU32210" /db_xref="EnsemblGenomes-Tr:CAB15211" /db_xref="InterPro:IPR009190" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG14053" /db_xref="UniProtKB/Swiss-Prot:O32118" /translation="MMKPVMLSVYGAENVCASCVNMPTAKDTYEWLEAALKRKYPNQP FEMQYIDIHEPPDNEHAKELAEKIRNDEYFYPLVLVEDKIVGEGNPKLKDVYEEMEKH GYTENR*" /label="yuzD CDS" gene complement(2934283..2934609) /gene="yuzD" /locus_tag="BSU_32210" /old_locus_tag="BSU32210" /label="yuzD gene" downshifts complement(2934306) /Source="Nicolas_upshifts" /id="D1671" /incds=0 /nref=4 /ntot=180 /MaxReadThrough="1.63835" /MaxDrop="3.17377" /score="-8.05690984" /energy="-10.8" /TU="NA" /idTUdmin="U2526" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2934641..2934660) /Source="Nicolas_upshift_promotors" /id="U2526" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.507492507492508" /psig="0.995004995004995" /xcortree=2229 /SigmaFactorBS="tatagcacattcagacttcaacacaaaaacggttttttTCTA TAAAaacgcccttaggCTCTGTATACTTAAAAGAAAggacttacataggagaaggggg c" /listShort="yuzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2934658) /Source="Nicolas_upshifts" /id="U2526" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.507492507492508" /psig="0.995004995004995" /xcortree=2229 /SigmaFactorBS="tatagcacattcagacttcaacacaaaaacggttttttTCTA TAAAaacgcccttaggCTCTGTATACTTAAAAGAAAggacttacataggagaaggggg c" /listShort="yuzD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2934673..2934680) /Source="Nicolas_upshift_promotors" /id="U2526" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.507492507492508" /psig="0.995004995004995" /xcortree=2229 /SigmaFactorBS="tatagcacattcagacttcaacacaaaaacggttttttTCTA TAAAaacgcccttaggCTCTGTATACTTAAAAGAAAggacttacataggagaaggggg c" /listShort="yuzD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2934693..2934697 /Source="Nicolas_upshift_promotors" /id="U2527" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=593 /SigmaFactorBS="acagagcctaagggcgtttttatagaaaaaaaccgtttTTGT GttgaagtctgaaTGTGCTATAATAGGGAAAGCaactttgcaaaccaaacaatagatt t" /listShort="yutI" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2934709..2935044 /gene="yutI" /locus_tag="BSU_32220" /old_locus_tag="BSU32220" /function="16.6: Maintain" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17237162, 21749987; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative iron-sulfur scaffold protein" /protein_id="NP_391102.1" /db_xref="EnsemblGenomes-Gn:BSU32220" /db_xref="EnsemblGenomes-Tr:CAB15212" /db_xref="GOA:O32119" /db_xref="InterPro:IPR001075" /db_xref="InterPro:IPR034904" /db_xref="SubtiList:BG14045" /db_xref="UniProtKB/Swiss-Prot:O32119" /translation="MCYNRESNFANQTIDFYCYTEYNGFMTTKGANVMTEVEMKEQVQ EVLDKLRPFLLRDGGDCELVDVDEGIVKLRLLGACGSCPSSTITLKAGIERALLEEVP GVVEVEQVF*" /label="yutI CDS" gene 2934709..2935044 /gene="yutI" /locus_tag="BSU_32220" /old_locus_tag="BSU32220" /label="yutI gene" promotor_-10 2934710..2934729 /Source="Nicolas_upshift_promotors" /id="U2527" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=593 /SigmaFactorBS="acagagcctaagggcgtttttatagaaaaaaaccgtttTTGT GttgaagtctgaaTGTGCTATAATAGGGAAAGCaactttgcaaaccaaacaatagatt t" /listShort="yutI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2934715 /Source="Nicolas_upshifts" /id="U2527" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=593 /SigmaFactorBS="acagagcctaagggcgtttttatagaaaaaaaccgtttTTGT GttgaagtctgaaTGTGCTATAATAGGGAAAGCaactttgcaaaccaaacaatagatt t" /listShort="yutI" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(2934834) /Source="Nicolas_upshifts" /id="D1672" /incds=1 /nref=1 /ntot=5 /MaxReadThrough="1.28655" /MaxDrop="3.45909" /score="7.3681553" /energy="-21.2" /TU="NA" /idTUdmin="U2528" /TUdmin=264 /isTUend="FALSE" /label="downshifts" downshifts 2935022 /Source="Nicolas_upshifts" /id="D1673" /incds=0 /nref=258 /ntot=281 /MaxReadThrough="3.6035" /MaxDrop="7.98922" /score="39.7008566" /energy="-19.5" /TU="U2527" /idTUdmin="U2527" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" CDS complement(2935086..2937059) /gene="yuxL" /locus_tag="BSU_32230" /old_locus_tag="BSU32230" /EC_number="3.4.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8576092, 11406580; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acylaminoacyl-peptidase" /protein_id="NP_391103.2" /db_xref="EnsemblGenomes-Gn:BSU32230" /db_xref="EnsemblGenomes-Tr:CAB15213" /db_xref="GOA:P39839" /db_xref="InterPro:IPR001375" /db_xref="InterPro:IPR011659" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG10463" /db_xref="UniProtKB/Swiss-Prot:P39839" /translation="MKKLITADDITAIVSVTDPQYAPDGTRAAYVKSQVNQEKDSYTS NIWIYETKTGGSVPWTHGEKRSTDPRWSPDGRTLAFISDREGDAAQLYIMSTEGGEAR KLTDIPYGVSKPLWSPDGESILVTVSLGEGESIDDREKTEQDSYEPVEVQGLSYKRDG KGLTRGAYAQLVLVSVKSGEMKELTSHKADHGDPAFSPDGKWLVFSANLTETDDASKP HDVYIMSLESGDLKQVTPHRGSFGSSSFSPDGRYLALLGNEKEYKNATLSKAWLYDIE QGRLTCLTEMLDVHLADALIGDSLIGGAEQRPIWTKDSQGFYVIGTDQGSTGIYYISI EGLVYPIRLEKEYINSFSLSPDEQHFIASVTKPDRPSELYSIPLGQEEKQLTGANDKF VREHTISIPEEIQYATEDGVMVNGWLMRPAQMEGETTYPLILNIHGGPHMMYGHTYFH EFQVLAAKGYAVVYINPRGSHGYGQEFVNAVRGDYGGKDYDDVMQAVDEAIKRDPHID PKRLGVTGGSYGGFMTNWIVGQTNRFKAAVTQRSISNWISFHGVSDIGYFFTDWQLEH DMFEDTEKLWDRSPLKYAANVETPLLILHGERDDRCPIEQAEQLFIALKKMGKETKLV RFPNASHNLSRTGHPRQRIKRLNYISSWFDQHL*" /label="yuxL CDS" gene complement(2935086..2937059) /gene="yuxL" /locus_tag="BSU_32230" /old_locus_tag="BSU32230" /label="yuxL gene" downshifts complement(2935098) /Source="Nicolas_upshifts" /id="D1674" /incds=0 /nref=19 /ntot=114 /MaxReadThrough="1.79797" /MaxDrop="3.85507" /score="7.3681553" /energy="-21.2" /TU="NA" /idTUdmin="U2528" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2937074..2937092) /Source="Nicolas_upshift_promotors" /id="U2528" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=501 /SigmaFactorBS="agcgttcctcagcgtcagcggagggcgcttttttttgctgga gatAAAGGAGTTtttatttagaaAAACGAAATACATGTAAAAaggaggagatgaatat g" /listShort="yuxL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2937097) /Source="Nicolas_upshifts" /id="U2528" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=501 /SigmaFactorBS="agcgttcctcagcgtcagcggagggcgcttttttttgctgga gatAAAGGAGTTtttatttagaaAAACGAAATACATGTAAAAaggaggagatgaatat g" /listShort="yuxL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2937104..2937112) /Source="Nicolas_upshift_promotors" /id="U2528" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=501 /SigmaFactorBS="agcgttcctcagcgtcagcggagggcgcttttttttgctgga gatAAAGGAGTTtttatttagaaAAACGAAATACATGTAAAAaggaggagatgaatat g" /listShort="yuxL" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2937167..2938096) /gene="thrB" /locus_tag="BSU_32240" /old_locus_tag="BSU32240" /EC_number="2.7.1.39" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3098560, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3098560, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="homoserine kinase" /protein_id="NP_391104.1" /db_xref="EnsemblGenomes-Gn:BSU32240" /db_xref="EnsemblGenomes-Tr:CAB15214" /db_xref="GOA:P04948" /db_xref="InterPro:IPR000870" /db_xref="InterPro:IPR006203" /db_xref="InterPro:IPR006204" /db_xref="InterPro:IPR013750" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR036554" /db_xref="SubtiList:BG10462" /db_xref="UniProtKB/Swiss-Prot:P04948" /translation="MNEADMLFSVTVPGSTANLGPGFDSVGMALSRYLKLTVFESDKW SFEAETETVAGIPAGTDNLIYQVAKRTADLYGKEMPPVHVKVWSDIPLARGLGSSAAA IVAAIELADELCGLKLSEADKLHLASLEEGHPDNAGASLVGGLVIGLHEDDETQMIRV PNADIDVVVVIPFYEVLTRDARDVLPKEFPYADAVKASAVSNILIAAIMSKDWPLVGK IMKKDMFHQPYRAMLVPELSKVEHVAEMKGAYGTALSGAGPTILVMTEKGKGEELKEQ LALHFPHCEVDALTVPKEGSIIERNPLYQVKSV*" /label="thrB CDS" gene complement(2937167..2938096) /gene="thrB" /locus_tag="BSU_32240" /old_locus_tag="BSU32240" /label="thrB gene" downshifts complement(2937180) /Source="Nicolas_upshifts" /id="D1675" /incds=0 /nref=222 /ntot=261 /MaxReadThrough="2.39521" /MaxDrop="7.03759" /score="15.5945196" /energy="-10.3" /TU="NA" /idTUdmin="U2530" /TUdmin="-14" /isTUend="TRUE" /label="downshifts" CDS complement(2938093..2939151) /gene="thrC" /locus_tag="BSU_32250" /old_locus_tag="BSU32250" /EC_number="4.2.3.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3098560, 3139660, 8768250" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3098560, 3139660, 8768250; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="threonine synthase" /protein_id="NP_391105.1" /db_xref="EnsemblGenomes-Gn:BSU32250" /db_xref="EnsemblGenomes-Tr:CAB15215" /db_xref="GOA:P04990" /db_xref="InterPro:IPR000634" /db_xref="InterPro:IPR001926" /db_xref="InterPro:IPR004450" /db_xref="InterPro:IPR026260" /db_xref="InterPro:IPR036052" /db_xref="SubtiList:BG10461" /db_xref="UniProtKB/Swiss-Prot:P04990" /translation="MWKGLIHQYKEFLPVTDQTPALTLHEGNTPLIHLPKLSEQLGIE LHVKTEGVNPTGSFKDRGMVMAVAKAKEEGNDTIMCASTGNTSAAAAAYAARANMKCI VIIPNGKIAFGKLAQAVMYGAEIIAIDGNFDDALKIVRSICEKSPIALVNSVNPYRIE GQKTAAFEVCEQLGEAPDVLAIPVGNAGNITAYWKGFKEYHEKNGTGLPKMRGFEAEG AAAIVRNEVIENPETIATAIRIGNPASWDKAVKAAEESNGKIDEVTDDEILHAYQLIA RVEGVFAEPGSCASIAGVLKQVKSGEIPKGSKVVAVLTGNGLKDPNTAVDISEIKPVT LPTDEDSILEYVKGAARV*" /label="thrC CDS" gene complement(2938093..2939151) /gene="thrC" /locus_tag="BSU_32250" /old_locus_tag="BSU32250" /label="thrC gene" CDS complement(2939151..2940452) /gene="hom" /locus_tag="BSU_32260" /old_locus_tag="BSU32260" /EC_number="1.1.1.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3139660, 27299409" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3139660, 27299409; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="homoserine dehydrogenase" /protein_id="NP_391106.1" /db_xref="EnsemblGenomes-Gn:BSU32260" /db_xref="EnsemblGenomes-Tr:CAB15216" /db_xref="GOA:P19582" /db_xref="InterPro:IPR001342" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR005106" /db_xref="InterPro:IPR016204" /db_xref="InterPro:IPR019811" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10460" /db_xref="UniProtKB/Swiss-Prot:P19582" /translation="MKAIRVGLLGLGTVGSGVVKIIQDHQDKLMHQVGCPVTIKKVLV KDLEKKREVDLPKEVLTTEVYDVIDDPDVDVVIEVIGGVEQTKQYLVDALRSKKHVVT ANKDLMAVYGSELLAEAKENGCDIYFEASVAGGIPILRTLEEGLSSDRITKMMGIVNG TTNFILTKMIKEKSPYEEVLKEAQDLGFAEADPTSDVEGLDAARKMAILARLGFSMNV DLEDVKVKGISQITDEDISFSKRLGYTMKLIGIAQRDGSKIEVSVQPTLLPDHHPLSA VHNEFNAVYVYGEAVGETMFYGPGAGSMPTATSVVSDLVAVMKNMRLGVTGNSFVGPQ YEKNMKSPSDIYAQQFLRIHVKDEVGSFSKITSVFSERGVSFEKILQLPIKGHDELAE IVIVTHHTSEADFSDILQNLNDLEVVQEVKSTYRVEGNGWS*" /label="hom CDS" gene complement(2939151..2940452) /gene="hom" /locus_tag="BSU_32260" /old_locus_tag="BSU32260" /label="hom gene" promotor_-35 2940337..2940346 /Source="Nicolas_upshift_promotors" /id="U2529" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1386 /SigmaFactorBS="tctctaaatcttttacaagcactttttttATCGTAACCGgac agccgacctgaTGCATAAGCTTATCCTGATGgtcttgaataattttaacgacaccgct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2940361..2940380 /Source="Nicolas_upshift_promotors" /id="U2529" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1386 /SigmaFactorBS="tctctaaatcttttacaagcactttttttATCGTAACCGgac agccgacctgaTGCATAAGCTTATCCTGATGgtcttgaataattttaacgacaccgct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2940368 /Source="Nicolas_upshifts" /id="U2529" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1386 /SigmaFactorBS="tctctaaatcttttacaagcactttttttATCGTAACCGgac agccgacctgaTGCATAAGCTTATCCTGATGgtcttgaataattttaacgacaccgct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2940453..2940534) /Source="Nicolas_S_feature" /locus_tag="new_3316130_3316211_c" /HighExp="T3.0H, T2.30H, T3.30H, S2, C90, T4.0H, BMM, SMM, MG 120, UNK1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1245" promotor_-10 complement(2940519..2940538) /Source="Nicolas_upshift_promotors" /id="U2530" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=3043 /SigmaFactorBS="agcgtttacattcgcaaaattcagcctaatgatgTCTTGTCA aaacaggagcgggcTTATATAATGTTTGTAACTTatatgtctgtgttgagttaacaat t" /listShort="S1245, hom, thrC, thrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2940534) /Source="Nicolas_upshifts" /id="U2530" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=3043 /SigmaFactorBS="agcgtttacattcgcaaaattcagcctaatgatgTCTTGTCA aaacaggagcgggcTTATATAATGTTTGTAACTTatatgtctgtgttgagttaacaat t" /listShort="S1245, hom, thrC, thrB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2940536..2940652) /Source="Nicolas_S_feature" /locus_tag="new_3316213_3316329_c" /HighExp="S5, S3, S4, S7, S6, S8, BT, B36, LoTm, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1246" promotor_-35 complement(2940553..2940560) /Source="Nicolas_upshift_promotors" /id="U2530" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=3043 /SigmaFactorBS="agcgtttacattcgcaaaattcagcctaatgatgTCTTGTCA aaacaggagcgggcTTATATAATGTTTGTAACTTatatgtctgtgttgagttaacaat t" /listShort="S1245, hom, thrC, thrB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2940653..2941672) /gene="cotNH" /locus_tag="BSU_32270" /old_locus_tag="BSU32270" /function="16.3: Control" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15231775, 22882546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15231775, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat-associated protein" /protein_id="NP_391107.1" /db_xref="EnsemblGenomes-Gn:BSU32270" /db_xref="EnsemblGenomes-Tr:CAB15217" /db_xref="GOA:O32123" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR014254" /db_xref="SubtiList:BG14044" /db_xref="UniProtKB/Swiss-Prot:O32123" /translation="MVKGTIKEKYGIHIRQLSMYQHTYQCFQTPNSYFLIVPVSQFSE TELAELYYMSQYLQEQSDPYVSVFIFTKEGELTFEHEGKTYALLKAAPPYSNRAFSIG AELAEFHRKGRGYPYEVKAAGRIGQWKDLWGKRIDQLEAFWQRKVQTPPHEPFDKKMI ESFPYYLGLSENAIQYLVDTELDDKPQAADSGTICHQRMERHTWSPESLIRIPADWVF DHASRDLAEYMRHTFLHHRQDFNQQGFLFLQEYEQVTPLSSFSKRLLYSRLLFPLHYF EIVESYYMSSESEKHYFEEQLDFILNDCGRYEQFLNTAQEFMNMRAQKLFVPRVSWLG KGSSR*" /label="cotNH CDS" gene complement(2940653..2941672) /gene="cotNH" /locus_tag="BSU_32270" /old_locus_tag="BSU32270" /label="cotNH gene" promotor_-35 2941480..2941485 /Source="Nicolas_upshift_promotors" /id="U2531" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.813186813186813" /psig="0.813186813186813" /xcortree=1020 /SigmaFactorBS="cagttcaccttcttttgtaaagataaaaaccgaaaCGTATGg gtcactttgttcttGTAAATACTGACTCATGTAataaagctccgccagctctgtttct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2941501..2941519 /Source="Nicolas_upshift_promotors" /id="U2531" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.813186813186813" /psig="0.813186813186813" /xcortree=1020 /SigmaFactorBS="cagttcaccttcttttgtaaagataaaaaccgaaaCGTATGg gtcactttgttcttGTAAATACTGACTCATGTAataaagctccgccagctctgtttct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2941505 /Source="Nicolas_upshifts" /id="U2531" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.813186813186813" /psig="0.813186813186813" /xcortree=1020 /SigmaFactorBS="cagttcaccttcttttgtaaagataaaaaccgaaaCGTATGg gtcactttgttcttGTAAATACTGACTCATGTAataaagctccgccagctctgtttct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2941695..2941713) /Source="Nicolas_upshift_promotors" /id="U2532" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1126 /SigmaFactorBS="ttgcgccttcttcggattaaaatatgtaTTCATAattccggc tgtgtatGACTACGATGTGATGAGCCctaattcaacaggcaggtgatcatggtgaaag g" /listShort="yutH, S1246, S1245, hom, thrC, thrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2941702) /Source="Nicolas_upshifts" /id="U2532" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1126 /SigmaFactorBS="ttgcgccttcttcggattaaaatatgtaTTCATAattccggc tgtgtatGACTACGATGTGATGAGCCctaattcaacaggcaggtgatcatggtgaaag g" /listShort="yutH, S1246, S1245, hom, thrC, thrB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2941711..2941716 /Source="Nicolas_upshift_promotors" /id="U2533" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1124 /SigmaFactorBS="tgatcacctgcctgttgaattagggctcatcacatcgtaGTC ATAcacagccggaattatGAATACATATTTTAATCCGaagaaggcgcaagaaaaagtc g" /listShort="S1247, yutG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2941729..2941734) /Source="Nicolas_upshift_promotors" /id="U2532" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1126 /SigmaFactorBS="ttgcgccttcttcggattaaaatatgtaTTCATAattccggc tgtgtatGACTACGATGTGATGAGCCctaattcaacaggcaggtgatcatggtgaaag g" /listShort="yutH, S1246, S1245, hom, thrC, thrB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2941732..2941796 /Source="Nicolas_S_feature" /locus_tag="new_3317409_3317473" /HighExp="S4, S5, S3, S6, S7, B36, S8, LoTm, Pyr, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1247" promotor_-10 2941732..2941750 /Source="Nicolas_upshift_promotors" /id="U2533" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1124 /SigmaFactorBS="tgatcacctgcctgttgaattagggctcatcacatcgtaGTC ATAcacagccggaattatGAATACATATTTTAATCCGaagaaggcgcaagaaaaagtc g" /listShort="S1247, yutG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2941732 /Source="Nicolas_upshifts" /id="U2533" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1124 /SigmaFactorBS="tgatcacctgcctgttgaattagggctcatcacatcgtaGTC ATAcacagccggaattatGAATACATATTTTAATCCGaagaaggcgcaagaaaaagtc g" /listShort="S1247, yutG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2941769..2941778 /Source="Nicolas_upshift_promotors" /id="U2534" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.86013986013986" /psig="0.86013986013986" /xcortree=1330 /SigmaFactorBS="atattttaatccgaagaaggcgcaagaaaaaGTCGTAAACTt ctcaagcatttTGTATAAACTAGTAAAAAAGattgggtgaagctgatgtcagaaaacg a" /listShort="yutG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2941791..2941810 /Source="Nicolas_upshift_promotors" /id="U2534" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.86013986013986" /psig="0.86013986013986" /xcortree=1330 /SigmaFactorBS="atattttaatccgaagaaggcgcaagaaaaaGTCGTAAACTt ctcaagcatttTGTATAAACTAGTAAAAAAGattgggtgaagctgatgtcagaaaacg a" /listShort="yutG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2941798 /Source="Nicolas_upshifts" /id="U2534" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.86013986013986" /psig="0.86013986013986" /xcortree=1330 /SigmaFactorBS="atattttaatccgaagaaggcgcaagaaaaaGTCGTAAACTt ctcaagcatttTGTATAAACTAGTAAAAAAGattgggtgaagctgatgtcagaaaacg a" /listShort="yutG" /GFF_Attribute="listLong" /label="upshifts" CDS 2941825..2942325 /gene="yutG" /locus_tag="BSU_32280" /old_locus_tag="BSU32280" /function="16.8: Protect" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphatidylglycerophosphatase" /protein_id="NP_391108.1" /db_xref="EnsemblGenomes-Gn:BSU32280" /db_xref="EnsemblGenomes-Tr:CAB15218" /db_xref="GOA:O32124" /db_xref="InterPro:IPR007686" /db_xref="InterPro:IPR026038" /db_xref="InterPro:IPR036681" /db_xref="SubtiList:BG14043" /db_xref="UniProtKB/Swiss-Prot:O32124" /translation="MSENEQFSQMEAKARARMKERGVEVSDIAELVFFLQKKYHPDLT IDECTLNVNRVLAKREVQNAILTGIELDVLAEQKKLSEPLQTMLEIDESLYGVDEVLA FSIVNIYGSIGFTNYGYIDKEKPGILKRLNDKSTGECHTFLDDIVGAISAAASSRLAH RARHTE*" /label="yutG CDS" gene 2941825..2942325 /gene="yutG" /locus_tag="BSU_32280" /old_locus_tag="BSU32280" /label="yutG gene" CDS complement(2942352..2943122) /gene="nucF" /locus_tag="BSU_32290" /old_locus_tag="BSU32290" /EC_number="3.1.3.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15664928, 16766528, 27907199" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15664928, 16766528, 27907199; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5' nucleotidase, promiscuous" /protein_id="NP_391109.1" /db_xref="EnsemblGenomes-Gn:BSU32290" /db_xref="EnsemblGenomes-Tr:CAB15219" /db_xref="GOA:O32125" /db_xref="InterPro:IPR006354" /db_xref="InterPro:IPR006357" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="PDB:3PDW" /db_xref="SubtiList:BG14042" /db_xref="UniProtKB/Swiss-Prot:O32125" /translation="MKTYKGYLIDLDGTMYNGTEKIEEACEFVRTLKDRGVPYLFVTN NSSRTPKQVADKLVSFDIPATEEQVFTTSMATAQHIAQQKKDASVYVIGEEGIRQAIE ENGLTFGGENADFVVVGIDRSITYEKFAVGCLAIRNGARFISTNGDIAIPTERGLLPG NGSLTSVLTVSTGVQPVFIGKPESIIMEQAMRVLGTDVSETLMVGDNYATDIMAGINA GMDTLLVHTGVTKREHMTDDMEKPTHAIDSLTEWIPYI*" /label="nucF CDS" gene complement(2942352..2943122) /gene="nucF" /locus_tag="BSU_32290" /old_locus_tag="BSU32290" /label="nucF gene" downshifts complement(2942380) /Source="Nicolas_upshifts" /id="D1676" /incds=0 /nref=137 /ntot=243 /MaxReadThrough="2.15034" /MaxDrop="4.82801" /score="8.09889752" /energy="-15.6" /TU="NA" /idTUdmin="U2535" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2943151..2943585) /gene="yutE" /locus_tag="BSU_32300" /old_locus_tag="BSU32300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 27907199" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391110.1" /db_xref="EnsemblGenomes-Gn:BSU32300" /db_xref="EnsemblGenomes-Tr:CAB15220" /db_xref="InterPro:IPR008201" /db_xref="PDB:1YLM" /db_xref="SubtiList:BG14041" /db_xref="UniProtKB/Swiss-Prot:O32126" /translation="MYFVDRSKIEKTLGFFEHQLALFDSQTDWQSEIGELALQRIGHL LIECILDTGNDMIDGFIMRDPGSYDDIMDILVDEKVVTEKEGDELKKLIAYRKTLVQQ YLLADSGELYRLIKAHQTALQDFPKRIRSYLETELGPVSAFK*" /label="yutE CDS" gene complement(2943151..2943585) /gene="yutE" /locus_tag="BSU_32300" /old_locus_tag="BSU32300" /label="yutE gene" CDS complement(2943609..2943884) /gene="yutD" /locus_tag="BSU_32310" /old_locus_tag="BSU32310" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12770717, 27907199" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391111.2" /db_xref="EnsemblGenomes-Gn:BSU32310" /db_xref="EnsemblGenomes-Tr:CAB15221" /db_xref="InterPro:IPR009370" /db_xref="PDB:2KL5" /db_xref="SubtiList:BG14040" /db_xref="UniProtKB/Swiss-Prot:O32127" /translation="MILIQNAEFELVHNFKDGFNEEAFKARYSDILNKYDYIVGDWGY GQLRLKGFFDDQNQKATFETKISTLDEYIYEYCNFGCAYFVLKRIRK*" /label="yutD CDS" gene complement(2943609..2943884) /gene="yutD" /locus_tag="BSU_32310" /old_locus_tag="BSU32310" /label="yutD gene" promotor_-10 complement(2943904..2943923) /Source="Nicolas_upshift_promotors" /id="U2535" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.65034965034965" /psig=1 /xcortree=2678 /SigmaFactorBS="cctcctcatgtgtagggtagccaaatcgcatgatttattctt tagCAATTGATggggacggggcaaTGAATTATGATAGGAATGAGtgaaaaaagaggtg a" /listShort="yutD, yutE, yutF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2943929) /Source="Nicolas_upshifts" /id="U2535" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.65034965034965" /psig=1 /xcortree=2678 /SigmaFactorBS="cctcctcatgtgtagggtagccaaatcgcatgatttattctt tagCAATTGATggggacggggcaaTGAATTATGATAGGAATGAGtgaaaaaagaggtg a" /listShort="yutD, yutE, yutF" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2943931..2944623) /Source="Nicolas_S_feature" /locus_tag="new_3319608_3320300_c" /HighExp="G135, G150, G180, H2O2, LBGtran, LBGexp, Paraq, dia15, C90, HiOs" /AntisenseName="yutC" /AntisenseCor="-0.57886192731570996" /AntisenseRegPval="-24.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1248" promotor_-35 complement(2943937..2943944) /Source="Nicolas_upshift_promotors" /id="U2535" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.65034965034965" /psig=1 /xcortree=2678 /SigmaFactorBS="cctcctcatgtgtagggtagccaaatcgcatgatttattctt tagCAATTGATggggacggggcaaTGAATTATGATAGGAATGAGtgaaaaaagaggtg a" /listShort="yutD, yutE, yutF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2943947..2943953 /Source="Nicolas_upshift_promotors" /id="U2536" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.711288711288711" /psig="0.711288711288711" /xcortree=851 /SigmaFactorBS="ataattcattgccccgtccccatcaattgctAAAGAATaaat catgcgatttGGCTACCCTACAcatgaggagggattgataaatgaaacgaaccgctgt c" /listShort="yutC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2943968..2943979 /Source="Nicolas_upshift_promotors" /id="U2536" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.711288711288711" /psig="0.711288711288711" /xcortree=851 /SigmaFactorBS="ataattcattgccccgtccccatcaattgctAAAGAATaaat catgcgatttGGCTACCCTACAcatgaggagggattgataaatgaaacgaaccgctgt c" /listShort="yutC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2943976 /Source="Nicolas_upshifts" /id="U2536" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.711288711288711" /psig="0.711288711288711" /xcortree=851 /SigmaFactorBS="ataattcattgccccgtccccatcaattgctAAAGAATaaat catgcgatttGGCTACCCTACAcatgaggagggattgataaatgaaacgaaccgctgt c" /listShort="yutC" /GFF_Attribute="listLong" /label="upshifts" CDS 2943999..2944631 /gene="yutC" /locus_tag="BSU_32320" /old_locus_tag="BSU32320" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative sporulation-related lipoprotein" /protein_id="NP_391112.1" /db_xref="EnsemblGenomes-Gn:BSU32320" /db_xref="EnsemblGenomes-Tr:CAB15222" /db_xref="GOA:O32128" /db_xref="InterPro:IPR019076" /db_xref="SubtiList:BG14039" /db_xref="UniProtKB/Swiss-Prot:O32128" /translation="MKRTAVSLCLLTGLLSGCGGAGLDNAQNVRNQTQNQTKPIHVSD RNEAFNRHNENEQFGYVRYQKEQFDGEQQKTPVMNREETAHMISSLTVQLPHIQDAAT LVTDREALVVYKTDSKNRELTADQVKKTAASVIPRYYHVYISDNPNHMQSVENYSNLG SGSRDIREIMSGTIQEMKTSPQGSPVSENENANGETRQDMKIDRNDKNAR*" /label="yutC CDS" gene 2943999..2944631 /gene="yutC" /locus_tag="BSU_32320" /old_locus_tag="BSU32320" /label="yutC gene" downshifts 2944592 /Source="Nicolas_upshifts" /id="D1677" /incds=0 /nref=9 /ntot=30 /MaxReadThrough="1.84979" /MaxDrop="3.55825" /score="-2.38634221" /energy="-9.6" /TU="NA" /idTUdmin="U2536" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2944647..2945543) /gene="lipA" /locus_tag="BSU_32330" /old_locus_tag="BSU32330" /EC_number="2.8.1.8" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15362861, 16835858, 19028902, 19820084, 25341020; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="lipoyl synthase (lipoic acid synthetase)" /protein_id="NP_391113.2" /db_xref="EnsemblGenomes-Gn:BSU32330" /db_xref="EnsemblGenomes-Tr:CAB15223" /db_xref="GOA:O32129" /db_xref="InterPro:IPR003698" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR031691" /db_xref="SubtiList:BG14038" /db_xref="UniProtKB/Swiss-Prot:O32129" /translation="MAKKDEHLRKPEWLKIKLNTNENYTGLKKLMRENNLHTVCEEAK CPNIHECWAVRRTATFMILGSVCTRACRFCAVKTGLPTELDLQEPERVADSVALMNLK HAVITAVARDDQKDGGAGIFAETVRAIRRKSPFTTIEVLPSDMGGNYDNLKTLMDTRP DILNHNIETVRRLTPRVRARATYDRSLEFLRRAKEMQPDIPTKSSIMIGLGETKEEII EVMDDLLANNVDIMAIGQYLQPTKKHLKVQKYYHPDEFAELKEIAMQKGFSHCEAGPL VRSSYHADEQVNEASKKRQAQA*" /label="lipA CDS" gene complement(2944647..2945543) /gene="lipA" /locus_tag="BSU_32330" /old_locus_tag="BSU32330" /label="lipA gene" downshifts complement(2944668) /Source="Nicolas_upshifts" /id="D1678" /incds=0 /nref=186 /ntot=261 /MaxReadThrough="3.83236" /MaxDrop="5.33309" /score="14.803008" /energy="-9.6" /TU="U2537" /idTUdmin="U2537" /TUdmin="-726" /isTUend="FALSE" /label="downshifts" S_feature complement(2945544..2945678) /Source="Nicolas_S_feature" /locus_tag="new_3321221_3321355_c" /HighExp="HiOs, LBGtran, dia15, dia5, C90, Diami, dia0, LBGexp, Heat, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1249" promotor_-10 complement(2945665..2945684) /Source="Nicolas_upshift_promotors" /id="U2537" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.651348651348651" /psig=1 /xcortree=2669 /SigmaFactorBS="gcaacccggcttaaaaatgtcagtaatcatcttcCCTTGtcg agaaatttttccTATGTTAAAGTGTCTAAAGAaaagactttctttagttagaaaaaca t" /listShort="S1249, lipA, S1248" /listLong="yutD, yutE, yutF" /label="promotor_-10" upshifts complement(2945678) /Source="Nicolas_upshifts" /id="U2537" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.651348651348651" /psig=1 /xcortree=2669 /SigmaFactorBS="gcaacccggcttaaaaatgtcagtaatcatcttcCCTTGtcg agaaatttttccTATGTTAAAGTGTCTAAAGAaaagactttctttagttagaaaaaca t" /listShort="S1249, lipA, S1248" /listLong="yutD, yutE, yutF" /label="upshifts" promotor_-35 complement(2945700..2945704) /Source="Nicolas_upshift_promotors" /id="U2537" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.651348651348651" /psig=1 /xcortree=2669 /SigmaFactorBS="gcaacccggcttaaaaatgtcagtaatcatcttcCCTTGtcg agaaatttttccTATGTTAAAGTGTCTAAAGAaaagactttctttagttagaaaaaca t" /listShort="S1249, lipA, S1248" /listLong="yutD, yutE, yutF" /label="promotor_-35" promotor_-35 2945718..2945724 /Source="Nicolas_upshift_promotors" /id="U2538" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=866 /SigmaFactorBS="aatttctcgacaagggaagatgattactGACATTTttaagcc gggttgCCGCAAACTATGtgtattcaatatgaaaggagattattttgtgaaagttttg t" /listShort="lytH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2945738..2945749 /Source="Nicolas_upshift_promotors" /id="U2538" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=866 /SigmaFactorBS="aatttctcgacaagggaagatgattactGACATTTttaagcc gggttgCCGCAAACTATGtgtattcaatatgaaaggagattattttgtgaaagttttg t" /listShort="lytH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2945750 /Source="Nicolas_upshifts" /id="U2538" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=866 /SigmaFactorBS="aatttctcgacaagggaagatgattactGACATTTttaagcc gggttgCCGCAAACTATGtgtattcaatatgaaaggagattattttgtgaaagttttg t" /listShort="lytH" /GFF_Attribute="listLong" /label="upshifts" CDS 2945778..2946758 /gene="lytH" /locus_tag="BSU_32340" /old_locus_tag="BSU32340" /EC_number="3.4.-.-" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12813075; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="sporulation-specific L-Ala-D-Glu endopeptidase" /protein_id="NP_391114.2" /db_xref="EnsemblGenomes-Gn:BSU32340" /db_xref="EnsemblGenomes-Tr:CAB15224" /db_xref="GOA:O32130" /db_xref="InterPro:IPR011055" /db_xref="InterPro:IPR016047" /db_xref="SubtiList:BG13975" /db_xref="UniProtKB/Swiss-Prot:O32130" /translation="MKVLLSALLLLLFAFEPSASGKKLSDPVLSKRMELYHKIEAVTQ IPWYALAAVDQYEENVRSNRKDLPEKAGIISIYIPDDIWSGPENPNPKDDAPLSIKVF DGIGMDGDGDGKAEVSNDEDILYTFSQYLLSYGTDEDNIRIGLWNYYRRDQTVGIISE FMKLFKAYGHIDLGEHAFPLPIRTDYSYRSTWGDARGFGGRRIHEGTDIFAHYGLPVK STCYGVVEMKGWNRFGGWRIGIRDINNTYHYFAHLNGFAKGIKTGQIVEPGQVIGSVG SSGYGPPGTAGKFPPHLHYGMYKDNGRTEWSFDPYPHLRAWERYEYQKKK*" /label="lytH CDS" gene 2945778..2946758 /gene="lytH" /locus_tag="BSU_32340" /old_locus_tag="BSU32340" /label="lytH gene" upshifts complement(2945856) /Source="Nicolas_upshifts" /id="U2539" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.832167832167832" /psig="0.873126873126873" /xcortree=2473 /SigmaFactorBS="aagggatCTGCgtcacagcttcgatttTATGATATAATTCCA TCCGTttcgacagcactggatctgaaagtttttttccagacgcagaaggctcaaatgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2945870..2945889) /Source="Nicolas_upshift_promotors" /id="U2539" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.832167832167832" /psig="0.873126873126873" /xcortree=2473 /SigmaFactorBS="aagggatCTGCgtcacagcttcgatttTATGATATAATTCCA TCCGTttcgacagcactggatctgaaagtttttttccagacgcagaaggctcaaatgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2945906..2945909) /Source="Nicolas_upshift_promotors" /id="U2539" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.832167832167832" /psig="0.873126873126873" /xcortree=2473 /SigmaFactorBS="aagggatCTGCgtcacagcttcgatttTATGATATAATTCCA TCCGTttcgacagcactggatctgaaagtttttttccagacgcagaaggctcaaatgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2946750 /Source="Nicolas_upshifts" /id="D1679" /incds=0 /nref=35 /ntot=74 /MaxReadThrough="0.613989999999999" /MaxDrop="8.59238" /score="-3.31011906" /energy="-20" /TU="NA" /idTUdmin="U2538" /TUdmin=2 /isTUend="TRUE" /label="downshifts" CDS complement(2946786..2947550) /gene="fisB" /locus_tag="BSU_32350" /old_locus_tag="BSU32350" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12662922, 23388828" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12662922, 23388828; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="protein required for membrane fission during spore formation" /protein_id="NP_391115.1" /db_xref="EnsemblGenomes-Gn:BSU32350" /db_xref="EnsemblGenomes-Tr:CAB15225" /db_xref="GOA:O32131" /db_xref="InterPro:IPR014197" /db_xref="SubtiList:BG13976" /db_xref="UniProtKB/Swiss-Prot:O32131" /translation="MPRYRGPFRKRGPLPFRYVMLLSVVFFILSTTVSLWMINGSIKP VLMDIGEMETKRIATEVIQDSIEDYMSDSENMKDMFQMNSDENGNLTTIDFNTQVVNS VKTKVTKQLQAHLKEMETHTGHSGASENIMINIPLGQVTGNSLLGNLGPKIPVRFNLI GDAFTDVKTKIKPYGINNALIDISIFVEIKVKVIIPFASKTAVVTNNVPVSIKAVQGE VPQFYNGSGGSGVTPSVQLPSSKENGADSKKEKSSK*" /label="fisB CDS" gene complement(2946786..2947550) /gene="fisB" /locus_tag="BSU_32350" /old_locus_tag="BSU32350" /label="fisB gene" downshifts complement(2946802) /Source="Nicolas_upshifts" /id="D1680" /incds=0 /nref=74 /ntot=226 /MaxReadThrough="3.15258" /MaxDrop="6.53891" /score="23.5286262" /energy="-12.4" /TU="NA" /idTUdmin="U2540" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2947564..2947582) /Source="Nicolas_upshift_promotors" /id="U2540" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1007 /SigmaFactorBS="gatgaaataaaataaattggccccggctaTTACTAtgtcccc tcttacaaGCATACATTGTGATATGTAaggggggattttcttgccaagatatcgcggc c" /listShort="yunB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2947572) /Source="Nicolas_upshifts" /id="U2540" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1007 /SigmaFactorBS="gatgaaataaaataaattggccccggctaTTACTAtgtcccc tcttacaaGCATACATTGTGATATGTAaggggggattttcttgccaagatatcgcggc c" /listShort="yunB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2947598..2947603) /Source="Nicolas_upshift_promotors" /id="U2540" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1007 /SigmaFactorBS="gatgaaataaaataaattggccccggctaTTACTAtgtcccc tcttacaaGCATACATTGTGATATGTAaggggggattttcttgccaagatatcgcggc c" /listShort="yunB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2947623..2947928) /gene="yunC" /locus_tag="BSU_32360" /old_locus_tag="BSU32360" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391116.1" /db_xref="EnsemblGenomes-Gn:BSU32360" /db_xref="EnsemblGenomes-Tr:CAB15226" /db_xref="InterPro:IPR014931" /db_xref="InterPro:IPR036493" /db_xref="SubtiList:BG13977" /db_xref="UniProtKB/Swiss-Prot:O32132" /translation="MVNLTPIMIEGQPFTAVTVKLPKTNFMAVANDHGYIMCGALDVA LLNEKLKERGIVAGRAVGVRTIDQLLDAPLESVTYAAEDLGIKVGMSGREALLKMMK* " /label="yunC CDS" gene complement(2947623..2947928) /gene="yunC" /locus_tag="BSU_32360" /old_locus_tag="BSU32360" /label="yunC gene" downshifts complement(2947631) /Source="Nicolas_upshifts" /id="D1681" /incds=0 /nref=3 /ntot=128 /MaxReadThrough="5.18714" /MaxDrop="3.9347" /score="-2.65376612" /energy="-18.9" /TU="U2541,U2543,U2544" /idTUdmin="U2540" /TUdmin="-829" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2947942..2947961) /Source="Nicolas_upshift_promotors" /id="U2541" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1347 /SigmaFactorBS="cgggatctgcttgcttggaagcttgcacaataaggcagtcag CCCACAACAagctgtgcccttcATCATAAAGTGATGAATGAAgggagtggttgacgtg g" /listShort="yunC, yunB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2947965) /Source="Nicolas_upshifts" /id="U2541" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1347 /SigmaFactorBS="cgggatctgcttgcttggaagcttgcacaataaggcagtcag CCCACAACAagctgtgcccttcATCATAAAGTGATGAATGAAgggagtggttgacgtg g" /listShort="yunC, yunB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2947975..2947983) /Source="Nicolas_upshift_promotors" /id="U2541" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1347 /SigmaFactorBS="cgggatctgcttgcttggaagcttgcacaataaggcagtcag CCCACAACAagctgtgcccttcATCATAAAGTGATGAATGAAgggagtggttgacgtg g" /listShort="yunC, yunB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2947993..2949381) /gene="yunD" /locus_tag="BSU_32370" /old_locus_tag="BSU32370" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative nuclease/nucleotidase/phosphoesterase" /protein_id="NP_391117.1" /db_xref="EnsemblGenomes-Gn:BSU32370" /db_xref="EnsemblGenomes-Tr:CAB15227" /db_xref="GOA:O32133" /db_xref="InterPro:IPR006179" /db_xref="InterPro:IPR008334" /db_xref="InterPro:IPR011240" /db_xref="InterPro:IPR029052" /db_xref="InterPro:IPR036907" /db_xref="SubtiList:BG13978" /db_xref="UniProtKB/Swiss-Prot:O32133" /translation="MKEKLRLYHTNDLHSHFENWPKIVDYIEQKRKEHQSDGEETLVF DIGDHLDRFQFVTEATFGKANVDLLNRLHIDGAAIGNNEGITLPHEELAALYDHAEFP VIVSNLFDKNGNRPSWAVPYHIKSLKNGMSIAFLGVTVPYYPVYDKLGWTVTDALESI KETILEVKGQADIIVLLSHLGILDDQAVAEAVPEIDVILESHTHHLLEDGQVVNGVLL ASAEKYGHYVGCVEITVDSVQRSINSKTASVQNMAEWTGESAETKAFLNEKEREAEEK LSDAVAELAQDAEVKWFEESELPLLLAYALKEWCETDISMVNSGVILGPLKAGPVTKL DLHRICPHPINPVAVRLTGEELKETIVHAASEQMEQLRIKGLGFRGEVMGKMVYAGVE VETKRLDDGITHVTRITLNGEDIEKHKQYSVAVLDMFTLGKLFPLIRDAAEKEYFMPE FLRDLLAWKLAQ*" /label="yunD CDS" gene complement(2947993..2949381) /gene="yunD" /locus_tag="BSU_32370" /old_locus_tag="BSU32370" /label="yunD gene" CDS complement(2949401..2950222) /gene="yunE" /locus_tag="BSU_32380" /old_locus_tag="BSU32380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_391118.1" /db_xref="EnsemblGenomes-Gn:BSU32380" /db_xref="EnsemblGenomes-Tr:CAB15228" /db_xref="GOA:O32134" /db_xref="InterPro:IPR002781" /db_xref="SubtiList:BG13979" /db_xref="UniProtKB/Swiss-Prot:O32134" /translation="MSFVILVVLGLIAGTVGSLIGLGGGIVIVPSLMFLSTVTQLFQD VTPQVAIGTSLLVIIFTGLSSTLAYIKYKTVDYKSGLIFFIGSGPGSMIGAYVSKLFN SNSFSVWFGIFMILISLSLMLKAKARPINKAHKGIIRTFQDDAGEPYTYSYQASVGIA IAFVVGFLGGLFGIGGGSLMVPAMMLLFLFPPKVAVATSMFIIFLSSMTGSVSHMISG HVNWLYALALVPGAWFGGKLGAAINRKMQTKTIVMIMRIVLILIGCQLIYEGIFS*" /label="yunE CDS" gene complement(2949401..2950222) /gene="yunE" /locus_tag="BSU_32380" /old_locus_tag="BSU32380" /label="yunE gene" CDS complement(2950240..2951088) /gene="yunF" /locus_tag="BSU_32390" /old_locus_tag="BSU32390" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391119.2" /db_xref="EnsemblGenomes-Gn:BSU32390" /db_xref="EnsemblGenomes-Tr:CAB15229" /db_xref="InterPro:IPR002763" /db_xref="InterPro:IPR036520" /db_xref="SubtiList:BG13980" /db_xref="UniProtKB/Swiss-Prot:O32135" /translation="MIYIGLTGWGDHDSIYPPKTASQKKLQAYSSHFPIVELDASFYA IQPARNNEKWVKETPETFQFIVKAYQGMTGHQRGEIPFDSKEEMFDAFKVSLTPYLHS NKLAMVLFQFPPWFDCKKENVAYLRWCKHQMGDIPCALEFRNRSWFSPPFYEQTLSFM KAEGWIHSVCDEPQIGEGSVPTVLRATDENKTLVRFHGRNKQGWMKPDGGKNWREVRY LYRYNQQELEDWKKHLNELQQQCKDVFVLFNNNSGGDAADNGKQMLELLDIEYSGLAP RQLDLF*" /label="yunF CDS" gene complement(2950240..2951088) /gene="yunF" /locus_tag="BSU_32390" /old_locus_tag="BSU32390" /label="yunF gene" promotor_-35 2950607..2950612 /Source="Nicolas_upshift_promotors" /id="U2542" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1206 /SigmaFactorBS="gacactgtgaatccagccttccgctTTCATAaatgaaagcgt ctgcTCATAAAATGGCGGCGAGAaccaggaacggtttctgaattcaagcgcgcaagga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2950628..2950646 /Source="Nicolas_upshift_promotors" /id="U2542" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1206 /SigmaFactorBS="gacactgtgaatccagccttccgctTTCATAaatgaaagcgt ctgcTCATAAAATGGCGGCGAGAaccaggaacggtttctgaattcaagcgcgcaagga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2950642 /Source="Nicolas_upshifts" /id="U2542" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1206 /SigmaFactorBS="gacactgtgaatccagccttccgctTTCATAaatgaaagcgt ctgcTCATAAAATGGCGGCGAGAaccaggaacggtttctgaattcaagcgcgcaagga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(2951099..2951118) /Source="Nicolas_upshift_promotors" /id="U2543" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=1989 /SigmaFactorBS="gcgtgaggcattttcccgccatatgaacagcatttccgagga aacctgaaaacacgTGTGATAAACTGGAAGAGAGgtgaatgagtgtgatttatatcgg a" /listShort="yunF, yunE, yunD, yunC, yunB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2951114) /Source="Nicolas_upshifts" /id="U2543" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=1989 /SigmaFactorBS="gcgtgaggcattttcccgccatatgaacagcatttccgagga aacctgaaaacacgTGTGATAAACTGGAAGAGAGgtgaatgagtgtgatttatatcgg a" /listShort="yunF, yunE, yunD, yunC, yunB" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2951126..2951473) /gene="yunG" /locus_tag="BSU_32400" /old_locus_tag="BSU32400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391120.1" /db_xref="EnsemblGenomes-Gn:BSU32400" /db_xref="EnsemblGenomes-Tr:CAB15230" /db_xref="SubtiList:BG13981" /db_xref="UniProtKB/Swiss-Prot:O32136" /translation="MEHVKYILKQSWSRHSSSKWTEECPSCGQCGVTALVIQDHFGGT IFKTRVDESWHFYNSINGVVYDFTSEQFQAPIEYQHIPSSREEAFLDTNEEQYQHLRE AFSRHMNSISEET*" /label="yunG CDS" gene complement(2951126..2951473) /gene="yunG" /locus_tag="BSU_32400" /old_locus_tag="BSU32400" /label="yunG gene" promotor_-10 complement(2951486..2951505) /Source="Nicolas_upshift_promotors" /id="U2544" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.594405594405594" /psig="0.95904095904096" /xcortree=2362 /SigmaFactorBS="ggcggattttaccgccgggttttttgatttcctccgttctAG TTTTTaaaatctcatcaaCGTGGTATCTTTTTTTAAAGgaggcggaggcaatggagca t" /listShort="yunG, yunF, yunE, yunD, yunC, yunB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2951505) /Source="Nicolas_upshifts" /id="U2544" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.594405594405594" /psig="0.95904095904096" /xcortree=2362 /SigmaFactorBS="ggcggattttaccgccgggttttttgatttcctccgttctAG TTTTTaaaatctcatcaaCGTGGTATCTTTTTTTAAAGgaggcggaggcaatggagca t" /listShort="yunG, yunF, yunE, yunD, yunC, yunB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2951519..2951525) /Source="Nicolas_upshift_promotors" /id="U2544" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.594405594405594" /psig="0.95904095904096" /xcortree=2362 /SigmaFactorBS="ggcggattttaccgccgggttttttgatttcctccgttctAG TTTTTaaaatctcatcaaCGTGGTATCTTTTTTTAAAGgaggcggaggcaatggagca t" /listShort="yunG, yunF, yunE, yunD, yunC, yunB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2951570..2952910) /gene="pucH" /locus_tag="BSU_32410" /old_locus_tag="BSU32410" /EC_number="3.5.2.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11344136, 12029039" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 12029039; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="allantoinase" /protein_id="NP_391121.1" /db_xref="EnsemblGenomes-Gn:BSU32410" /db_xref="EnsemblGenomes-Tr:CAB15231" /db_xref="GOA:O32137" /db_xref="InterPro:IPR006680" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR017593" /db_xref="InterPro:IPR032466" /db_xref="SubtiList:BG13982" /db_xref="UniProtKB/Swiss-Prot:O32137" /translation="MAYDMVIKGAKAVTPDGVIEADIVVQNGVIAEIGSDIEASGTEI IQADGKYVFPGVIDCHVHFNEPGREDWEGFETGSQMMAAGGCTTYFDMPLNCIPSTVT AEHLLAKAELGRQKSAVDFALWGGLVPGHIEDIRPMAEAGAIGFKAFLSKSGTDEFRS VDERTLLKGMAEIAAAGKILALHAESDAITSYLQMVLANKGKVDADAYAASRPEEAEV EAVYRTIQYAKVTGCPVHFVHISTAKAVRLIREAKQEGLDVSVETCPHYVLFSHDDLR QRGSVAKCAPPLRSRQSKETLIETLIAGDIDMVSSDHSPCRPSLKREDNMFLSWGGIS GGQFTLLGMLELALEHQIPFETIAEWTAAAPAKRFGLQKKGRLEAGCDADFVLVSMEP YTVTRESMFAKHKKSIYEGHTFPCSISATYSKGRCVYNDGEKVTEIDGALVVPS*" /label="pucH CDS" gene complement(2951570..2952910) /gene="pucH" /locus_tag="BSU_32410" /old_locus_tag="BSU32410" /label="pucH gene" downshifts complement(2951598) /Source="Nicolas_upshifts" /id="D1682" /incds=0 /nref=5 /ntot=28 /MaxReadThrough="0.88847" /MaxDrop="3.89144" /score="36.6188375" /energy="-15.4" /TU="NA" /idTUdmin="U2540" /TUdmin="-4796" /isTUend="FALSE" /label="downshifts" downshifts complement(2952654) /Source="Nicolas_upshifts" /id="D1683" /incds=1 /nref=1 /ntot=7 /MaxReadThrough="3.38784" /MaxDrop="3.36547" /score="36.6188375" /energy="-15.4" /TU="NA" /idTUdmin="U2540" /TUdmin="-5852" /isTUend="FALSE" /label="downshifts" promotor_-35 2952967..2952973 /Source="Nicolas_upshift_promotors" /id="U2545" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.432567432567433" /psig="0.96103896103896" /xcortree=318 /SigmaFactorBS="cgattttccatgtcagtttatgtaacacaaccAGTTCTAttt tcaacagtttACTGCTACTATGATCGTATTacatcagcaaaaccgctagaattcctat t" /listShort="S1250, pucR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2952987..2953006 /Source="Nicolas_upshift_promotors" /id="U2545" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.432567432567433" /psig="0.96103896103896" /xcortree=318 /SigmaFactorBS="cgattttccatgtcagtttatgtaacacaaccAGTTCTAttt tcaacagtttACTGCTACTATGATCGTATTacatcagcaaaaccgctagaattcctat t" /listShort="S1250, pucR" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2952989..2953007) /Source="Nicolas_upshift_promotors" /id="U2546" /multdbtbs="SigA" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1026 /SigmaFactorBS="ataaaaacattggttaaggtgaataattttcaataggaATTC TAgcggttttgctgatgTAATACGATCATAGTAGCAgtaaactgttgaaaatagaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2952995 /Source="Nicolas_upshifts" /id="U2545" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.432567432567433" /psig="0.96103896103896" /xcortree=318 /SigmaFactorBS="cgattttccatgtcagtttatgtaacacaaccAGTTCTAttt tcaacagtttACTGCTACTATGATCGTATTacatcagcaaaaccgctagaattcctat t" /listShort="S1250, pucR" /GFF_Attribute="listLong" /label="upshifts" S_feature 2952996..2953084 /Source="Nicolas_S_feature" /locus_tag="new_3328673_3328761" /HighExp="BT, Cold, S0, LBGexp, S1, Lbtran, G150, T-1.40H, G180, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.961" /TUlongSig="NA" /TUlongPSig="NA" /label="S1250" upshifts complement(2953006) /Source="Nicolas_upshifts" /id="U2546" /multdbtbs="SigA" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1026 /SigmaFactorBS="ataaaaacattggttaaggtgaataattttcaataggaATTC TAgcggttttgctgatgTAATACGATCATAGTAGCAgtaaactgttgaaaatagaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2953023..2953028) /Source="Nicolas_upshift_promotors" /id="U2546" /multdbtbs="SigA" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1026 /SigmaFactorBS="ataaaaacattggttaaggtgaataattttcaataggaATTC TAgcggttttgctgatgTAATACGATCATAGTAGCAgtaaactgttgaaaatagaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2953085..2954680 /gene="pucR" /locus_tag="BSU_32420" /old_locus_tag="BSU32420" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11344136, 12029039, 12374841" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 12029039, 12374841; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of the purine degradation operon" /protein_id="NP_391122.1" /db_xref="EnsemblGenomes-Gn:BSU32420" /db_xref="EnsemblGenomes-Tr:CAB15232" /db_xref="GOA:O32138" /db_xref="InterPro:IPR012914" /db_xref="InterPro:IPR025736" /db_xref="InterPro:IPR028979" /db_xref="SubtiList:BG13983" /db_xref="UniProtKB/Swiss-Prot:O32138" /translation="MNILDVMKIPAFENANLIAGKAGGEREVQHVNMMDAPDIVDFLH KNELLVTTAYHLKDHPHQLSELIRQMAKRGCAGLGIKTKRYLEDIPKEIIELADSYAF PIIELPEHIRLGDIVNATLSHILDMRSNELQQAIYAHKKFTNHIMSGKGLQSLLKKVS DILQLPVLLLDQHAKMLSASHQISVETEKLKGTLNTVSGPFFTCFSTISDQKTYSVLP IYNHEKNCGYLLIPDMVQAGDKGLILTIEQAANVISFELLKENALKQFSRRARNEFFN NFIERTFSSDDEIKNRAKEFKLRWDQKYMCIAGKLDRNDESISFTENQLASDSVFEFL EGELSAFPFPPHFFMKGNVGIILIEATDSWSEMHASVISFLEQFQTQVSAQFKRTVSF GISNICQKLIDVPDAFTEASDALQSGHLSRSTAFIQVYHAKDVPELLRLLPVEDLKKF YNSTLQSLAEKQQEDQSLLHTLSVYLETHCQISETAKRLYVHRNTVIYRLEKCEELLG KSLKDPETTMRLRLALRMQRLIS*" /label="pucR CDS" gene 2953085..2954680 /gene="pucR" /locus_tag="BSU_32420" /old_locus_tag="BSU32420" /label="pucR gene" CDS 2954825..2956174 /gene="pucJ" /locus_tag="BSU_32430" /old_locus_tag="BSU32430" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11344136, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="uric acid permease" /protein_id="NP_391123.1" /db_xref="EnsemblGenomes-Gn:BSU32430" /db_xref="EnsemblGenomes-Tr:CAB15233" /db_xref="GOA:O32139" /db_xref="InterPro:IPR006042" /db_xref="InterPro:IPR006043" /db_xref="InterPro:IPR017588" /db_xref="SubtiList:BG13984" /db_xref="UniProtKB/Swiss-Prot:O32139" /translation="MKKRSFKVFTLSLQHVLAMYAGAILVPLLVGRALNVTTEQLSYL LAIDLLTCGVATLLQTLRGTYIGIGLPVMLGSSFVAVTPMIAIGSNYGIHAIYGSIIA AGVFIFLFARFFGKLTVLFPPVVTGTVVTLIGLSLVPTGVKNMAGGEKINGSANPEYG SLENLLLSVGVLVLILVLNRFLKGFARTLSVLIGIAAGTAAAAIMGKVSFSSVTEAPF FQIPKPFYFGAPAFEIGPILTMLIVGIVIIVESTGVFYAIGKICGRPLTDKDLVKGYR AEGIAILIGGLFNAFPYNTFAQNAGLLQLTKVKTRNIVVTAGCILVCLGLIPKIAALA SAVPAAVLGGATVVMFGMVIASGVKMLSTADLKNQYHLLTIACSIALGIGASTAPGIF AEFPAPIRILVSDGTITGSLTAIFLNLFFSLRDKKELTAQQTELPVLEHTLALEKEV* " /label="pucJ CDS" gene 2954825..2956174 /gene="pucJ" /locus_tag="BSU_32430" /old_locus_tag="BSU32430" /label="pucJ gene" CDS 2956180..2957472 /gene="pucK" /locus_tag="BSU_32440" /old_locus_tag="BSU32440" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11344136, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="uric acid permease subunit" /protein_id="NP_391124.1" /db_xref="EnsemblGenomes-Gn:BSU32440" /db_xref="EnsemblGenomes-Tr:CAB15234" /db_xref="GOA:O32140" /db_xref="InterPro:IPR006042" /db_xref="InterPro:IPR006043" /db_xref="InterPro:IPR017588" /db_xref="SubtiList:BG13985" /db_xref="UniProtKB/Swiss-Prot:O32140" /translation="MKEQHNALQLMMLGLQHMLAMYAGAILVPLIVGAAIGLNAGQLT YLIAIDLFMCGAATLLQLWRNRYFGIGLPVVLGCTFTAVGPMISIGSTYGVPAIYGAI IAAGLIVVLAAGFFGKLVRFFPPVVTGSVVMIIGISLIPTAMNNLAGGEGSKEFGSLD NVLLGFGVTAFILLLFYFFKGFIRSIAILLGLIAGTAAAYFMGKVDFSEVLEASWLHV PSLFYFGPPTFELPAVVTMLLVAIVSLVESTGVYFALADITNRRLSEKDLEKGYRAEG LAILLGGLFNAFPYTAFSQNVGIVQLSKMKSVNVIAITGIILVAIGLVPKAAALTTVI PTPVLGGAMIVMFGMVISYGIKMLSSVDLDSQGNLLIIASSVSLGLGATTVPALFSSL SGAASVLAGSGIVIGSLTAIALHAFFQTKQPNSADIKT*" /label="pucK CDS" gene 2956180..2957472 /gene="pucK" /locus_tag="BSU_32440" /old_locus_tag="BSU32440" /label="pucK gene" CDS 2957485..2958969 /gene="pucL" /locus_tag="BSU_32450" /old_locus_tag="BSU32450" /EC_number="1.7.3.3" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11344136, 12823818, 17567580, 20168977, 23760935, 28531234" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 12823818, 17567580, 20168977, 23760935, 28531234; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="urate oxidase with peroxide reductase N-terminaldomain" /protein_id="NP_391125.1" /db_xref="EnsemblGenomes-Gn:BSU32450" /db_xref="EnsemblGenomes-Tr:CAB15235" /db_xref="GOA:O32141" /db_xref="InterPro:IPR002042" /db_xref="InterPro:IPR017580" /db_xref="InterPro:IPR018020" /db_xref="InterPro:IPR019842" /db_xref="InterPro:IPR036778" /db_xref="SubtiList:BG13986" /db_xref="UniProtKB/Swiss-Prot:O32141" /translation="MFTMDDLNQMDTQTLTDTLGSIFEHSSWIAERSAALRPFSSLSD LHRKMTGIVKAADRETQLDLIKKHPRLGTKKTMSDDSVREQQNAGLGKLEQQEYEEFL MLNEHYYDRFGFPFILAVKGKTKQDIHQALLARLESERETEFQQALIEIYRIARFRLA DIITEKGETQMKRTMSYGKGNVFAYRTYLKPLTGVKQIPESSFAGRDNTVVGVDVTCE IGGEAFLPSFTDGDNTLVVATDSMKNFIQRHLASYEGTTTEGFLHYVAHRFLDTYSHM DTITLTGEDIPFEAMPAYEEKELSTSRLVFRRSRNERSRSVLKAERSGNTITITEQYS EIMDLQLVKVSGNSFVGFIRDEYTTLPEDGNRPLFVYLNISWQYENTNDSYASDPARY VAAEQVRDLASTVFHELETPSIQNLIYHIGCRILARFPQLTDVSFQSQNHTWDTVVEE IPGSKGKVYTEPRPPYGFQHFTVTREDAEKEKQKAAEKCRSLKA*" /label="pucL CDS" gene 2957485..2958969 /gene="pucL" /locus_tag="BSU_32450" /old_locus_tag="BSU32450" /label="pucL gene" CDS 2958969..2959313 /gene="pucM" /locus_tag="BSU_32460" /old_locus_tag="BSU32460" /EC_number="3.5.2.17" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11344136, 16098976, 16782815, 21795808" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 16098976, 16782815, 21795808; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-hydroxyisourate hydrolase; also uricase subunit" /protein_id="NP_391126.2" /db_xref="EnsemblGenomes-Gn:BSU32460" /db_xref="EnsemblGenomes-Tr:CAB15236" /db_xref="GOA:O32142" /db_xref="InterPro:IPR000895" /db_xref="InterPro:IPR014306" /db_xref="InterPro:IPR023416" /db_xref="InterPro:IPR023418" /db_xref="InterPro:IPR023419" /db_xref="InterPro:IPR036817" /db_xref="PDB:2H0E" /db_xref="PDB:2H0F" /db_xref="PDB:2H0J" /db_xref="SubtiList:BG13987" /db_xref="UniProtKB/Swiss-Prot:O32142" /translation="MGKLTTHILDLTCGKPAANVKIGLKRLGESIMKEVYTNNDGRVD VPLLAGEELMSGEYVMEFHAGDYFASKNMNAADQPFLTIVTVRFQLADPDAHYHIPLL LSPFGYQVYRGS*" /label="pucM CDS" gene 2958969..2959313 /gene="pucM" /locus_tag="BSU_32460" /old_locus_tag="BSU32460" /label="pucM gene" promotor_-35 2959035..2959038 /Source="Nicolas_upshift_promotors" /id="U2547" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95104895104895" /psig="0.975024975024975" /xcortree=2067 /SigmaFactorBS="ggcaaaccagcggcgaacgtaaaaattGGATtgaagcggctg ggcgaaAGTATTATGAAAGAGGTATAcactaacaatgacggcagggtcgatgtccctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2959056..2959075 /Source="Nicolas_upshift_promotors" /id="U2547" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95104895104895" /psig="0.975024975024975" /xcortree=2067 /SigmaFactorBS="ggcaaaccagcggcgaacgtaaaaattGGATtgaagcggctg ggcgaaAGTATTATGAAAGAGGTATAcactaacaatgacggcagggtcgatgtccctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2959068 /Source="Nicolas_upshifts" /id="U2547" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95104895104895" /psig="0.975024975024975" /xcortree=2067 /SigmaFactorBS="ggcaaaccagcggcgaacgtaaaaattGGATtgaagcggctg ggcgaaAGTATTATGAAAGAGGTATAcactaacaatgacggcagggtcgatgtccctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2959288 /Source="Nicolas_upshifts" /id="D1684" /incds=0 /nref=3 /ntot=90 /MaxReadThrough="1.80149" /MaxDrop="3.57243" /score="20.0549891" /energy="-14.2" /TU="NA" /idTUdmin="U2547" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2959329..2959716) /Source="Nicolas_S_feature" /locus_tag="new_3335006_3335393_c" /HighExp="BT, S8, T2.0H, LBGstat, Cold, Etha, Sw, T1.0H, T1.30H, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1251" promotor_-35 2959676..2959685 /Source="Nicolas_upshift_promotors" /id="U2548" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1423 /SigmaFactorBS="agacaaaatattcattttttcttttttagacttaaATCTATG TCGaaaataatcgttGGCATATCTTATCCTATCTCcactaaaggaggtgacattatgg g" /listShort="yuzJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2959698..2959717 /Source="Nicolas_upshift_promotors" /id="U2548" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1423 /SigmaFactorBS="agacaaaatattcattttttcttttttagacttaaATCTATG TCGaaaataatcgttGGCATATCTTATCCTATCTCcactaaaggaggtgacattatgg g" /listShort="yuzJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2959701 /Source="Nicolas_upshifts" /id="U2548" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1423 /SigmaFactorBS="agacaaaatattcattttttcttttttagacttaaATCTATG TCGaaaataatcgttGGCATATCTTATCCTATCTCcactaaaggaggtgacattatgg g" /listShort="yuzJ" /GFF_Attribute="listLong" /label="upshifts" ncRNA complement(2959737..2959868) /ncRNA_class="antisense_RNA" /gene="auzJ" /locus_tag="BSU_ncRNA_2" /product="putative antisense RNA for type I YuzJ toxin" /note="Evidence 3: Putative function from multiple computational evidences" /label="auzJ ncRNA" CDS 2959737..2959868 /gene="yuzJ" /locus_tag="BSU_32469" /old_locus_tag="BSU32469" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20156992, 20525796, 21670523; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative type I toxin" /protein_id="YP_003097780.1" /db_xref="EnsemblGenomes-Gn:BSU32469" /db_xref="EnsemblGenomes-Tr:CAX52686" /db_xref="GOA:C0H3Q7" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/Swiss-Prot:C0H3Q7" /translation="MGFYNSGGYSGNSGYSNGFGSSFALIVVLFILLIIVGAAIFNY* " /label="yuzJ CDS" gene 2959737..2959868 /gene="yuzJ" /locus_tag="BSU_32469" /old_locus_tag="BSU32469" /label="yuzJ gene" gene complement(2959737..2959868) /gene="auzJ" /locus_tag="BSU_ncRNA_2" /label="auzJ gene" S_feature 2959869..2959937 /Source="Nicolas_S_feature" /locus_tag="new_3335546_3335614" /HighExp="BT, B36, S8, G/S, B60, Pyr, Glucon, C30, S7, Mal" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1252" downshifts 2959904 /Source="Nicolas_upshifts" /id="D1685" /incds=0 /nref=10 /ntot=25 /MaxReadThrough="0.61379" /MaxDrop="6.43101" /score="20.0549891" /energy="-14.2" /TU="NA" /idTUdmin="U2548" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2960074..2960595) /gene="pucE" /locus_tag="BSU_32470" /old_locus_tag="BSU32470" /EC_number="1.17.1.4" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9098051, 11344136, 18569337; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xanthine dehydrogenase, iron-sulfur subunit" /protein_id="NP_391127.1" /db_xref="EnsemblGenomes-Gn:BSU32470" /db_xref="EnsemblGenomes-Tr:CAB15237" /db_xref="GOA:O32143" /db_xref="InterPro:IPR001041" /db_xref="InterPro:IPR002888" /db_xref="InterPro:IPR006058" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR017611" /db_xref="InterPro:IPR036010" /db_xref="InterPro:IPR036884" /db_xref="SubtiList:BG13988" /db_xref="UniProtKB/Swiss-Prot:O32143" /translation="MDIKEAGPFPVKKEQFRMTVNGQAWEVAAVPTTHLSDLLRKEFQ LTGTKVSCGIGRCGACSILIDGKLANACMTMAYQADGHSITTIEGLQKEELDMCQTAF LEEGGFQCGYCTPGMIIALKALFRETPQPSDKDIEEGLAGNLCRCTGYGGIMRSACRI RRELNGGRRESGF*" /label="pucE CDS" gene complement(2960074..2960595) /gene="pucE" /locus_tag="BSU_32470" /old_locus_tag="BSU32470" /label="pucE gene" CDS complement(2960586..2962823) /gene="pucD" /locus_tag="BSU_32480" /old_locus_tag="BSU32480" /EC_number="1.17.1.4" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9098051, 11344136, 18569337; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xanthine dehydrogenase, substrate and molybdenumcofactor subunit" /protein_id="NP_391128.1" /db_xref="EnsemblGenomes-Gn:BSU32480" /db_xref="EnsemblGenomes-Tr:CAB15238" /db_xref="GOA:O32144" /db_xref="InterPro:IPR000674" /db_xref="InterPro:IPR008274" /db_xref="InterPro:IPR017609" /db_xref="InterPro:IPR036856" /db_xref="InterPro:IPR037165" /db_xref="SubtiList:BG13989" /db_xref="UniProtKB/Swiss-Prot:O32144" /translation="MIINKPSRVRPDGRGKVTGELKYMTDLSFPGMLYGKVLRSAYPH AEIVSVCTIKAEKMEGVQAVVTHKDVPGLNRFGIVIPDQPVLCEDRVRYVGDAIAAVA AETEEIAEAALELIQVEYKELEVMDSPEKALRPNAQRLHEDGNILHRAFFSNGDVEEG FQASDTVFEETYELPRQMHTYMETEGGVAVPEDDGGFTMYAGTQHGYKDRFQLARIFD IPEEKIRIVSSPMGGSFGGKDELNIQPYAALLALKSGRPVKIHQTRKESVRSGIKRHP MKITIKTGADHSGNLLAHDVKIVADTGAYATLGPAVLDFSVEHAAGPYRIPNIRTEGI SVFTNNGVAGEFRGFGGNQITFALETHLDRLSGMLGIDPLELRRKNIRKPHDLGPLEH RIAPTDGAAQVLNAISKSPILKKTSRNCGYLQRGTGAAITMHGGGLGFGRMDAAGGRL SLSSEGKITASFGFEECGQGILAAIEQIVMEELGCAAEDISIVIGDTAKVPKSGSSTA SRGTSMVWHAIQRLKKPFLAQLKKRAAEWSGCSAENLIPGAAGLRDKNTKALVVTYKE LAEKGPLAEETAFDFPTTPDPVVGGHFLYSFGAAAVEVEVDLLTGDVKLIDCEHAIAA GPVVSPQGYRGQIEGGAAMALGYTLMEEAKMTDGRYAAENLDHYLIPGIKDVPDMKLI AIEDLMKGDVYGPRGVGEIGTIAITPAIVKAVHDAVGCWINKLPISREELLEAIDRKG LKQWT*" /label="pucD CDS" gene complement(2960586..2962823) /gene="pucD" /locus_tag="BSU_32480" /old_locus_tag="BSU32480" /label="pucD gene" CDS complement(2962824..2963657) /gene="pucC" /locus_tag="BSU_32490" /old_locus_tag="BSU32490" /EC_number="1.17.1.4" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9098051, 11344136, 18569337; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xanthine dehydrogenase, FAD-binding subunit" /protein_id="NP_391129.1" /db_xref="EnsemblGenomes-Gn:BSU32490" /db_xref="EnsemblGenomes-Tr:CAB15239" /db_xref="GOA:O32145" /db_xref="InterPro:IPR002346" /db_xref="InterPro:IPR016166" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR017612" /db_xref="InterPro:IPR036318" /db_xref="InterPro:IPR036683" /db_xref="SubtiList:BG13990" /db_xref="UniProtKB/Swiss-Prot:O32145" /translation="MNGQVTKARMNIQLWRPAALDEAYSLLEKLAPDVCAASGSTLLQ LQWDKGTLPKQHLVSLEGIDEMRGISTSDTHVSIGGLTSLNECRKNPLIKRALSCFSD AASAVAAPGIRSRATIGGNIASKIGDFIPLLLVLGAELIVYQKELIRLPLGAWLSEED FRTAIVTRVIIPRAEGERVFYHKLGRRQAFTGAAAVAAGRFLKDGSIRLAAGHADITP RRLLDSEAKWMAPGWDPHELYKTLIHELPFSSDVFMSAAYRKKAAANVIMAELMAEGG E*" /label="pucC CDS" gene complement(2962824..2963657) /gene="pucC" /locus_tag="BSU_32490" /old_locus_tag="BSU32490" /label="pucC gene" CDS complement(2963654..2964271) /gene="pucB" /locus_tag="BSU_32500" /old_locus_tag="BSU32500" /EC_number="2.7.7.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11344136, 21528011; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative molybdopterin cofactor synthesis cytidylyl transferase" /protein_id="NP_391130.2" /db_xref="EnsemblGenomes-Gn:BSU32500" /db_xref="EnsemblGenomes-Tr:CAB15240" /db_xref="GOA:O32146" /db_xref="InterPro:IPR017615" /db_xref="InterPro:IPR025877" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG13991" /db_xref="UniProtKB/Swiss-Prot:O32146" /translation="MRSPYLIGVFLAAGKSRRMGQNKLALPLKGENIGSLSLKTALSS RLDHVLVVERTEHASLEWIGAPYHAPPFQKRWSLHVCQDAEKGQGHSVSSGVRKAESM GADGIVILLADQPQLSVDHLNALVALAPESFAVSSFLGAFTPPIYFSSTCFPYVKGLK GDEGARRLLKSGQLGAGAVLEAKDSGELDDIDTPEEYDMVRRAMS*" /label="pucB CDS" gene complement(2963654..2964271) /gene="pucB" /locus_tag="BSU_32500" /old_locus_tag="BSU32500" /label="pucB gene" downshifts complement(2963763) /Source="Nicolas_upshifts" /id="D1686" /incds=1 /nref=3 /ntot=13 /MaxReadThrough="5.34639" /MaxDrop="3.22355" /score="-4.87239629" /energy="-9.9" /TU="U2549" /idTUdmin="U2549" /TUdmin="-3827" /isTUend="FALSE" /label="downshifts" CDS complement(2964268..2965260) /gene="pucA" /locus_tag="BSU_32510" /old_locus_tag="BSU32510" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10217763, 11344136, 12029039" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10217763, 11344136, 12029039; Product type f: factor" /codon_start=1 /transl_table=11 /product="xanthine dehydrogenase molybdopterin recruitmentfactor" /protein_id="NP_391131.1" /db_xref="EnsemblGenomes-Gn:BSU32510" /db_xref="EnsemblGenomes-Tr:CAB15241" /db_xref="GOA:O32147" /db_xref="InterPro:IPR003777" /db_xref="InterPro:IPR027051" /db_xref="SubtiList:BG13992" /db_xref="UniProtKB/Swiss-Prot:O32147" /translation="MGNFHTMLDALLEDQEEAVLATIVQVEGSAYRKAGASMLFKKKG RRIGLLSGGCVEEDVFQRISALGDQLTSTLIPYDMRSEDDLSWGMGAGCNGIIHVHAE RITQEKRRHYEKVRDCLHSGKAVTSVIKIESSHYLFLTENGHFGNWPDAPLQDIQRTV STLHLPHFDQTTNMFIQRIEPKPRLILFGAGPDNVPLANLAADTGFSVIVTDWRPAYC TSSLFPKADQLITAFPEQMLSEFQFFPHDAAVVATHHYQHDQTIINFLFSQNLHYIGL LGSANRTKRLLSGKHPPSHFYSPVGLKIGAEGPEEIAVSVVAEIIQTRKRVAVV*" /label="pucA CDS" gene complement(2964268..2965260) /gene="pucA" /locus_tag="BSU_32510" /old_locus_tag="BSU32510" /label="pucA gene" S_feature complement(2965261..2965347) /Source="Nicolas_S_feature" /locus_tag="new_3340938_3341024_c" /HighExp="BT, Cold, Sw, T-1.10H, S1, C30, S0, T-0.40H, T-3.40H, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.607" /TUlongSig="NA" /TUlongPSig="NA" /label="S1253" promotor_-10 complement(2965325..2965344) /Source="Nicolas_upshift_promotors" /id="U2549" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.477522477522478" /psig="0.607392607392607" /xcortree=1437 /SigmaFactorBS="ttttacaaatcctctttctatgtgtttcattttctgacaaat caTGAGTCattttttcttccaTCGTCTATTCTTTATACAAGttacctataaaatcacg c" /listShort="S1253, pucA, pucB, pucC, pucD, pucE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2965347) /Source="Nicolas_upshifts" /id="U2549" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.477522477522478" /psig="0.607392607392607" /xcortree=1437 /SigmaFactorBS="ttttacaaatcctctttctatgtgtttcattttctgacaaat caTGAGTCattttttcttccaTCGTCTATTCTTTATACAAGttacctataaaatcacg c" /listShort="S1253, pucA, pucB, pucC, pucD, pucE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2965358..2965363) /Source="Nicolas_upshift_promotors" /id="U2549" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.477522477522478" /psig="0.607392607392607" /xcortree=1437 /SigmaFactorBS="ttttacaaatcctctttctatgtgtttcattttctgacaaat caTGAGTCattttttcttccaTCGTCTATTCTTTATACAAGttacctataaaatcacg c" /listShort="S1253, pucA, pucB, pucC, pucD, pucE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2965489..2966739) /gene="pucG" /locus_tag="BSU_32520" /old_locus_tag="BSU32520" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11344136, 20852637, 28032445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 20852637, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="(S)-ureidoglycine-glyoxylate aminotransferase (PLP-dependent)" /protein_id="NP_391132.1" /db_xref="EnsemblGenomes-Gn:BSU32520" /db_xref="EnsemblGenomes-Tr:CAB15242" /db_xref="GOA:O32148" /db_xref="InterPro:IPR000192" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR020578" /db_xref="InterPro:IPR024169" /db_xref="PDB:3ISL" /db_xref="SubtiList:BG13993" /db_xref="UniProtKB/Swiss-Prot:O32148" /translation="MSGRRELCTPLRTIMTPGPVEVDPRVLRVMSTPVVGQFDPAFTG IMNETMEMLRELFQTKNRWAYPIDGTSRAGIEAVLASVIEPEDDVLIPIYGRFGYLLT EIAERYGANVHMLECEWGTVFDPEDIIREIKKVKPKIVAMVHGETSTGRIHPLKAIGE ACRTEDALFIVDAVATIGGCEVKVDEWKIDAAIGGTQKCLSVPSGMAPITYNERVADV IAARKKVERGIATQADRAALSGNRPITSNYFDLSQLEDYWSERRLNHHTEATTMLYAL REGVRLVLEEGLETRFERHRHHEAALAAGIKAMGLRLFGDDSCKMPVVTCVEIPGGID GESVRDMLLAQFGIEIASSFGPLAGKIWRIGTMGYSCRKENVLFVLAGLEAVLLRHNA GIEAGKALQAALDVYENAGRQAAV*" /label="pucG CDS" gene complement(2965489..2966739) /gene="pucG" /locus_tag="BSU_32520" /old_locus_tag="BSU32520" /label="pucG gene" CDS complement(2966756..2967994) /gene="pucF" /locus_tag="BSU_32530" /old_locus_tag="BSU32530" /EC_number="3.5.3.9" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11344136, 17362992, 25020232; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="allantoate amidohydrolase" /protein_id="NP_391133.1" /db_xref="EnsemblGenomes-Gn:BSU32530" /db_xref="EnsemblGenomes-Tr:CAB15243" /db_xref="GOA:O32149" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR010158" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG13994" /db_xref="UniProtKB/Swiss-Prot:O32149" /translation="MEKQKLSVKNSITDYIEWLAQYGASADGGVTRLLYTKEWMDAQL AVKTEMSSFGLETRFDDVGNVFGRLSGTQSPDEVIVTGSHIDTVINGGKYDGAYGVLA AMLALKQLKETYGAPKKTLEAVSLCEEEGSRFPMTYWGSGNMTGVFSEQDAKEPRDES GVSLQTAMHESGFGKGVFQSAYRTDISAFVELHIEQGKTLEMSGRDLGIVTSIAGQRR YLVTLEGECNHAGTTSMKWRKDPLAASSRIIHELLLRSDELPDELRLTCGKITAEPNV ANVIPGRVQFSIDIRHQHQHVLEQFHQDMVALINGICLQKGIRAVIDEYMRIEPVPMD ERLKAAAFETALENGFSCEEMVSGAGHDAQMIGRRYPACMLFVPSRGGVSHSPKEYTS ARQLEIGVRALTDLLYKLAY*" /label="pucF CDS" gene complement(2966756..2967994) /gene="pucF" /locus_tag="BSU_32530" /old_locus_tag="BSU32530" /label="pucF gene" CDS 2968217..2968354 /locus_tag="BSU_32539" /old_locus_tag="BSU32539" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514002.1" /translation="MNKLSWRGDVRGTDENRNAGSPQKQDLKIWKQEISASSKGTNLQ F*" /label="hypothetical protein CDS" gene 2968217..2968354 /locus_tag="BSU_32539" /old_locus_tag="BSU32539" /label="gene" promotor_-35 2968376..2968379 /Source="Nicolas_upshift_promotors" /id="U2550" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.921078921078921" /psig=1 /xcortree=463 /SigmaFactorBS="ggactaatttacaattttaatgaaaaatatacaaaatgacaC TTCtatcctttatttcaATTTTAGATAATAGATATGAtctgataaaaggagggcaagt g" /listShort="bsn" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2968394..2968413 /Source="Nicolas_upshift_promotors" /id="U2550" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.921078921078921" /psig=1 /xcortree=463 /SigmaFactorBS="ggactaatttacaattttaatgaaaaatatacaaaatgacaC TTCtatcctttatttcaATTTTAGATAATAGATATGAtctgataaaaggagggcaagt g" /listShort="bsn" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2968395 /Source="Nicolas_upshifts" /id="U2550" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.921078921078921" /psig=1 /xcortree=463 /SigmaFactorBS="ggactaatttacaattttaatgaaaaatatacaaaatgacaC TTCtatcctttatttcaATTTTAGATAATAGATATGAtctgataaaaggagggcaagt g" /listShort="bsn" /GFF_Attribute="listLong" /label="upshifts" CDS 2968436..2969302 /gene="bsnA" /locus_tag="BSU_32540" /old_locus_tag="BSU32540" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1396690, 12490701, 12883447, 16291680, 25844442" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1396690, 12490701, 12883447, 16291680, 25844442; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="extracellular ribonuclease" /protein_id="NP_391134.1" /db_xref="EnsemblGenomes-Gn:BSU32540" /db_xref="EnsemblGenomes-Tr:CAB15244" /db_xref="GOA:O32150" /db_xref="InterPro:IPR007346" /db_xref="SubtiList:BG13995" /db_xref="UniProtKB/Swiss-Prot:O32150" /translation="MTKKAWFLPLVCVLLISGWLAPAASASAQTTLSLNDRLASSPSG TGSLLSLAAPAAPYADTDTYYEGAEGKTGDSLKSTLHRIISGHTMLSYSEVWNALKET DEDPRNPNNVILLYTNESRSKNLNGGNVGDWNREHVWAKSHGDFGTSKGPGTDIHHLR PADVQVNSARGNMDFDNGGTEYAKAPGNYYDGDSWEPRDDVKGDVARMLFYMAVRYEG DDGYPDLELNDKTGNGSAPYHGKQSVLLEWNKQDPVDDRERKRNEIIYEKYQHNRNPF IDHPEWADEIWP*" /label="bsnA CDS" gene 2968436..2969302 /gene="bsnA" /locus_tag="BSU_32540" /old_locus_tag="BSU32540" /label="bsnA gene" downshifts 2969305 /Source="Nicolas_upshifts" /id="D1687" /incds=0 /nref=48 /ntot=190 /MaxReadThrough="0.45317" /MaxDrop="6.90997" /score="25.7790712" /energy="-15.5" /TU="NA" /idTUdmin="U2550" /TUdmin=8 /isTUend="TRUE" /label="downshifts" CDS complement(2969336..2970439) /gene="frlP" /locus_tag="BSU_32550" /old_locus_tag="BSU32550" /EC_number="3.6.3.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:23175651, 27501980" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23175651, 27501980; Product type t: transporter" /codon_start=1 /transl_table=11 /product="fructose-amino acid ABC transporter (ATP-bindingsubunit)" /protein_id="NP_391135.1" /db_xref="EnsemblGenomes-Gn:BSU32550" /db_xref="EnsemblGenomes-Tr:CAB15245" /db_xref="GOA:O32151" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR008995" /db_xref="InterPro:IPR013611" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13996" /db_xref="UniProtKB/Swiss-Prot:O32151" /translation="MASLTFEHVKKSYHSQLTVKDFDLDVKDKELLVLVGPSGCGKST TLRMVAGLESISEGNLLIDGERVNDLPPKERDIAMVFQNYALYPHMTVFDNMAFGLKL RKMAKQEIAERVHAAARILEIEHLLKRKPKALSGGQRQRVALGRSIVREPKVFLMDEP LSNLDAKLRVTMRTEISKLHQRLEATIIYVTHDQTEAMTMGDRIVVMNEGEIQQVAKP HDIYHYPANLFVAGFIGSPGMNFLKGIIEQQHGELFFTNSSIRLHIPEEKAKRLKEKG YAGEQMIAGVRPEHITQMTGNDQLFDSVFQANVEVNENLGSELIVHVMAGDERLKVRL DGNTRIDAGDSIQLSVKMDHVVFFDAETEEAVY*" /label="frlP CDS" gene complement(2969336..2970439) /gene="frlP" /locus_tag="BSU_32550" /old_locus_tag="BSU32550" /label="frlP gene" downshifts complement(2969351) /Source="Nicolas_upshifts" /id="D1688" /incds=0 /nref=57 /ntot=215 /MaxReadThrough="3.04361" /MaxDrop="6.06171" /score="29.1144499" /energy="-15.5" /TU="NA" /idTUdmin="U2553" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2970440..2971373) /Source="Nicolas_S_feature" /locus_tag="new_3346117_3347050_c" /HighExp="HiOs, T-5.40H, T5.0H, GM-0.1, S2, GM-0.2, GM 5, T-4.40H, T4.0H, SMM" /AntisenseName="frlR" /AntisenseCor="0.22682293682100099" /AntisenseRegPval="-3.8" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-, SigA" /TUshortPSig="0.971, 0.456, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1254" promotor_-35 2970477..2970484 /Source="Nicolas_upshift_promotors" /id="U2551" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.743256743256743" /psig="0.996003996003996" /xcortree=3177 /SigmaFactorBS="tccccctatcttttgacccgttatttcgtCACTGGAAacaac ttggtcttTCTGTTATTTTTAGAGTAATcgattcccatttttgctatatttctaaaat a" /listShort="frlR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2970498..2970517 /Source="Nicolas_upshift_promotors" /id="U2551" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.743256743256743" /psig="0.996003996003996" /xcortree=3177 /SigmaFactorBS="tccccctatcttttgacccgttatttcgtCACTGGAAacaac ttggtcttTCTGTTATTTTTAGAGTAATcgattcccatttttgctatatttctaaaat a" /listShort="frlR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2970508 /Source="Nicolas_upshifts" /id="U2551" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.743256743256743" /psig="0.996003996003996" /xcortree=3177 /SigmaFactorBS="tccccctatcttttgacccgttatttcgtCACTGGAAacaac ttggtcttTCTGTTATTTTTAGAGTAATcgattcccatttttgctatatttctaaaat a" /listShort="frlR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2970559..2970565 /Source="Nicolas_upshift_promotors" /id="U2552" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.503496503496504" /psig="0.996003996003996" /xcortree=2434 /SigmaFactorBS="atcgattcccatttttgctatatttctaaaataaaaaatgta aATTTGTAttataacgtcataaTACATTATAATATAAATAATaggttaaaaggaggct a" /listShort="frlR" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2970576 /Source="Nicolas_upshifts" /id="U2552" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.503496503496504" /psig="0.996003996003996" /xcortree=2434 /SigmaFactorBS="atcgattcccatttttgctatatttctaaaataaaaaatgta aATTTGTAttataacgtcataaTACATTATAATATAAATAATaggttaaaaggaggct a" /listShort="frlR" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2970580..2970599 /Source="Nicolas_upshift_promotors" /id="U2552" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.503496503496504" /psig="0.996003996003996" /xcortree=2434 /SigmaFactorBS="atcgattcccatttttgctatatttctaaaataaaaaatgta aATTTGTAttataacgtcataaTACATTATAATATAAATAATaggttaaaaggaggct a" /listShort="frlR" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2970621..2971349 /gene="frlR" /locus_tag="BSU_32560" /old_locus_tag="BSU32560" /experiment="publication(s) with functional evidences, PMID:21347729, 21398478, 24673833" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21347729, 21398478, 24673833; Product type r: regulator" /codon_start=1 /transl_table=11 /product="FrlR transcriptional regulator (GntR family)" /protein_id="NP_391136.3" /db_xref="EnsemblGenomes-Gn:BSU32560" /db_xref="EnsemblGenomes-Tr:CAB15246" /db_xref="GOA:O32152" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR011663" /db_xref="InterPro:IPR028978" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2IKK" /db_xref="SubtiList:BG13997" /db_xref="UniProtKB/Swiss-Prot:O32152" /translation="MLNNGSSTPLYIQLKQIITDDIKKGVYSPTAKLPTENELCTKYN VSRITVRKAILDLVEEGYLIRQQGKGTFVKSPKLKRELIAVNGYSEFMESTGKKPKHH VLSHDIIPASKPIAEKLQIQPESPVVELKRILYNDDQPLTFEVTHYPLDLFPGIDTFI ADGVSMHDILKQQYKVVPTHNTKLLNVVYAQQEESKYLDCDIGDALFEIDKTAFTSND QPIYCSLFLMHTNRVTFTINSPYT*" /label="frlR CDS" gene 2970621..2971349 /gene="frlR" /locus_tag="BSU_32560" /old_locus_tag="BSU32560" /label="frlR gene" CDS complement(2971374..2972228) /gene="frlD" /locus_tag="BSU_32570" /old_locus_tag="BSU32570" /EC_number="2.7.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 14641112, 15556630, 16153181, 21347729, 21398478, 22720735; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="fructoselysine kinase" /protein_id="NP_391137.1" /db_xref="EnsemblGenomes-Gn:BSU32570" /db_xref="EnsemblGenomes-Tr:CAB15247" /db_xref="GOA:O32153" /db_xref="InterPro:IPR002173" /db_xref="InterPro:IPR011611" /db_xref="InterPro:IPR029056" /db_xref="SubtiList:BG13998" /db_xref="UniProtKB/Swiss-Prot:O32153" /translation="MKLIAVGDNVVDYYQDQETFYPGGNALNVAVLAKRLGHESSYIG IVGNDEAAAHLLNVLKLEQVNADYIRQAHGENGMAIVTLDEQGDRIFVRSNKGGIQSR LRLAFQEKDVSFISGHDLLHTSVYSRLENDLPQLCGLVPVSFDFSTNREDDYLRRVCP YVTYAFFSGSDLSESECGELAKTAHGYGAKMVCMTRGGQGAILSAGDRVYHQPIVEAD IIDTLGAGDSFIAGFLTAFCVKQDITYALRQAAETAAKTCGVYGAFGYGYPYRLEDGG SSEKTRIL*" /label="frlD CDS" gene complement(2971374..2972228) /gene="frlD" /locus_tag="BSU_32570" /old_locus_tag="BSU32570" /label="frlD gene" misc_feature complement(2971561..2971580) /Source="Nicolas_upshift_promotors" /id="U2553" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.77022977022977" /psig="0.971028971028971" /xcortree=571 /SigmaFactorBS="aaggagcaatcctgtctgcgggtgatcgagtctatcatcagc cgattgtggaaGCTGATATAATAGATACACTtggagcgggagattcttttatagcagg c" /listShort="S1254, yurJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2971573) /Source="Nicolas_upshifts" /id="U2553" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.77022977022977" /psig="0.971028971028971" /xcortree=571 /SigmaFactorBS="aaggagcaatcctgtctgcgggtgatcgagtctatcatcagc cgattgtggaaGCTGATATAATAGATACACTtggagcgggagattcttttatagcagg c" /listShort="S1254, yurJ" /GFF_Attribute="listLong" /label="upshifts" promotor_no_box complement(2971731..2971831) /Source="Nicolas_upshift_promotors" /id="U2554" /multdbtbs="-" /comp="M19" /sig="Sig-" /pcomp="0.320679320679321" /psig="0.455544455544456" /xcortree=1631 /SigmaFactorBS="ttccgcagctgtgcgggctggtcccggtctcatttgattttt caaccaatcgggaggatgattatttgaggagggtctgtccttatgtgacgtatgcgtt t" /listShort="S1254, yurJ" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(2971771) /Source="Nicolas_upshifts" /id="U2554" /multdbtbs="-" /comp="M19" /sig="Sig-" /pcomp="0.320679320679321" /psig="0.455544455544456" /xcortree=1631 /SigmaFactorBS="ttccgcagctgtgcgggctggtcccggtctcatttgattttt caaccaatcgggaggatgattatttgaggagggtctgtccttatgtgacgtatgcgtt t" /listShort="S1254, yurJ" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2972242..2973144) /gene="frlM" /locus_tag="BSU_32580" /old_locus_tag="BSU32580" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12618455, 15849754, 16850406, 15556630, 21347729; Product type t : transporter" /codon_start=1 /transl_table=11 /product="fructose-amino acid permease" /protein_id="NP_391138.1" /db_xref="EnsemblGenomes-Gn:BSU32580" /db_xref="EnsemblGenomes-Tr:CAB15248" /db_xref="GOA:O32154" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG13999" /db_xref="UniProtKB/Swiss-Prot:O32154" /translation="MLPQKKTDSFRLEPVPDQHIEVKDKPRRKWYIGETSVWVFLFLY LIAIAYPLLWMVMSAFKNSDDIFEHSWSLPSSWHPENFVSAWNQGISSYFMNSVIVTA LTCVITVFISAWAAYGLSRFEFKGKGFFLVLCLGGLMLTPQVSLVPLYSIIQSLGLYN TYWALILPYAAYRIPFTIILIRSYFLSISKELEEAAYLDGCTSFGVFFRIFLPMSVPI LVTSGILTAYHTWNEFMFAIIFIDDENLRTIPAGLMQFRDALQTDWGVLLAGLTISAA PIIILFLLMQKYFVRGIASGSVKG*" /label="frlM CDS" gene complement(2972242..2973144) /gene="frlM" /locus_tag="BSU_32580" /old_locus_tag="BSU32580" /label="frlM gene" CDS complement(2973148..2974026) /gene="frlN" /locus_tag="BSU_32590" /old_locus_tag="BSU32590" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12618455, 15849754, 16850406, 15556630, 21347729; Product type t : transporter" /codon_start=1 /transl_table=11 /product="fructose-amino acid permease" /protein_id="NP_391139.1" /db_xref="EnsemblGenomes-Gn:BSU32590" /db_xref="EnsemblGenomes-Tr:CAB15249" /db_xref="GOA:O32155" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035277" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG14000" /db_xref="UniProtKB/Swiss-Prot:O32155" /translation="MVNQNKIIPYLFLVPALVFLLFVYIPIFENVFLSLFQWSSFSPE KTFIGLKNYVELFHDPVFYQALTNNVLYAVISIVCQVFGGLILAAVLEDKLVRKWSPF FRTVFFLPVVISMTVIALLFDFIYNPETGLLNQLLQAIGLDQLTRAWLGDDSTAMLSV IFVSQWQSVGYIAMLYIVSIQKIPDELYEAARLDGAGKIQQFFHITVPQTKEMSFVAV VMTLTGAFTVFNEPYILTGGGPGKASEVLSTFLYKSAFTKDMMGYASAIATVVLIITL ALSLMQMKFFKTGKEE*" /label="frlN CDS" gene complement(2973148..2974026) /gene="frlN" /locus_tag="BSU_32590" /old_locus_tag="BSU32590" /label="frlN gene" CDS complement(2974084..2975352) /gene="frlO" /locus_tag="BSU_32600" /old_locus_tag="BSU32600" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12618455, 21347729; Product type t: transporter" /codon_start=1 /transl_table=11 /product="fructose amino acid-binding lipoprotein" /protein_id="NP_391140.1" /db_xref="EnsemblGenomes-Gn:BSU32600" /db_xref="EnsemblGenomes-Tr:CAB15250" /db_xref="GOA:O32156" /db_xref="InterPro:IPR006059" /db_xref="SubtiList:BG14001" /db_xref="UniProtKB/Swiss-Prot:O32156" /translation="MKKMLLFLIIAAVSMLTIAGCSSQSSSADGKVTLKFFHRWPKEP EKSYFEEVVKEFEKDHPDIDIQIEAVLNDSYKDKIKVMLGTTSPPDIYFSWSDEFAFK FIRGNKALDLSSYYKNDTDWSSQLVQSQITPFTYENKQYGVPWQMDAKSFFYNKDIFQ KLNLDPPKTWDELIDVSKKLKEHGYTPISFGTKATWTISHYIGTLNQRMVDEKTREKD YNAKTGEFTDEGYVKALEKLQELMPYFNKHVNSVDHEYVRQQFKSGKSAMIYAETAEI KLVEPVNLGMFPFPEISGQKGSSEALTGAPEGFMISSRTKHPKEAMEFLQFLTSKRMG EKLVKDVGKYSAVQGTATEENATAIQREAVQHIVDAKSMVPWFDMDVDVEVADAYLTG VQQMLGGDMTPQQVMKAVQKAAKQVRASAE*" /label="frlO CDS" gene complement(2974084..2975352) /gene="frlO" /locus_tag="BSU_32600" /old_locus_tag="BSU32600" /label="frlO gene" promotor_no_box 2975243..2975343 /Source="Nicolas_upshift_promotors" /id="U2555" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.99100899100899" /psig="0.000999000999001" /xcortree=21 /SigmaFactorBS="aaaaatttcaatgtcacctttccgtccgctgaactgctttgg ctcgaacagcctgcgatggtgagcatactgacagctgcaatgatcaagaacaacaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 2975303 /Source="Nicolas_upshifts" /id="U2555" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.99100899100899" /psig="0.000999000999001" /xcortree=21 /SigmaFactorBS="aaaaatttcaatgtcacctttccgtccgctgaactgctttgg ctcgaacagcctgcgatggtgagcatactgacagctgcaatgatcaagaacaacaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(2975423) /Source="Nicolas_upshifts" /id="D1689" /incds=0 /nref=21 /ntot=141 /MaxReadThrough="7.96763" /MaxDrop="4.994" /score="3.53212058" /energy="-13.8" /TU="U2557" /idTUdmin="U2558" /TUdmin=1210 /isTUend="FALSE" /label="downshifts" CDS complement(2975433..2976419) /gene="frlB" /locus_tag="BSU_32610" /old_locus_tag="BSU32610" /EC_number="3.5.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 12618455, 15556630, 16153181, 18083814, 21347729, 21398478, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fructosamine-6-P deglycase" /protein_id="NP_391141.1" /db_xref="EnsemblGenomes-Gn:BSU32610" /db_xref="EnsemblGenomes-Tr:CAB15251" /db_xref="GOA:O32157" /db_xref="InterPro:IPR001347" /db_xref="InterPro:IPR024713" /db_xref="InterPro:IPR035488" /db_xref="InterPro:IPR035490" /db_xref="PDB:3EUA" /db_xref="SubtiList:BG14002" /db_xref="UniProtKB/Swiss-Prot:O32157" /translation="MSQATAKVNREVQAFLQDLKGKTIDHVFFVACGGSSAIMYPSKY VFDRESKSINSDLYSANEFIQRNPVQLGEKSLVILCSHSGNTPETVKAAAFARGKGAL TIAMTFKPESPLAQEAQYVAQYDWGDEALAINTNYGVLYQIVFGTLQVLENNTKFEQA IEGLDQLQAVYEKALKQEADNAKQFAKAHEKESIIYTMASGANYGVAYSYSICILMEM QWIHSHAIHAGEYFHGPFEIIDESVPFIILLGLDETRPLEERALTFSKKYGKKLTVLD AASYDFTAIDDSVKGYLAPLVLNRVLRSYADELAEERNHPLSHRRYMWKVEY*" /label="frlB CDS" gene complement(2975433..2976419) /gene="frlB" /locus_tag="BSU_32610" /old_locus_tag="BSU32610" /label="frlB gene" upshifts 2976366 /Source="Nicolas_upshifts" /id="U2556" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.972027972027972" /psig="0.002997002997003" /xcortree=22 /SigmaFactorBS="aatggcagaagaccctccgcatgcgacaaagaatacatgatc aatggttttccctttcaaatcCTGCAagaaagcttgaacctcacgatttacttttgct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 2976369..2976373 /Source="Nicolas_upshift_promotors" /id="U2556" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.972027972027972" /psig="0.002997002997003" /xcortree=22 /SigmaFactorBS="aatggcagaagaccctccgcatgcgacaaagaatacatgatc aatggttttccctttcaaatcCTGCAagaaagcttgaacctcacgatttacttttgct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(2976462..2976481) /Source="Nicolas_upshift_promotors" /id="U2557" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2897 /SigmaFactorBS="cgaataaattattgagaaatttcagaaaataaTATTGACAat cctacccgcggaCTTTAATATAACAATATATAatgttatataacgttatataataaaa a" /listShort="frlB, frlO, frlN, frlM, frlD, S1254, yurJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2976475) /Source="Nicolas_upshifts" /id="U2557" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2897 /SigmaFactorBS="cgaataaattattgagaaatttcagaaaataaTATTGACAat cctacccgcggaCTTTAATATAACAATATATAatgttatataacgttatataataaaa a" /listShort="frlB, frlO, frlN, frlM, frlD, S1254, yurJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2976496..2976503) /Source="Nicolas_upshift_promotors" /id="U2557" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2897 /SigmaFactorBS="cgaataaattattgagaaatttcagaaaataaTATTGACAat cctacccgcggaCTTTAATATAACAATATATAatgttatataacgttatataataaaa a" /listShort="frlB, frlO, frlN, frlM, frlD, S1254, yurJ" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2976633) /Source="Nicolas_upshifts" /id="D1690" /incds=0 /nref=116 /ntot=274 /MaxReadThrough="0.87627" /MaxDrop="5.35981" /score="3.53212058" /energy="-13.8" /TU="NA" /idTUdmin="U2558" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2976635..2977009) /gene="yurQ" /locus_tag="BSU_32620" /old_locus_tag="BSU32620" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative excinuclease" /protein_id="NP_391142.1" /db_xref="EnsemblGenomes-Gn:BSU32620" /db_xref="EnsemblGenomes-Tr:CAB15252" /db_xref="GOA:O32158" /db_xref="InterPro:IPR000305" /db_xref="InterPro:IPR014527" /db_xref="InterPro:IPR035901" /db_xref="SubtiList:BG14003" /db_xref="UniProtKB/Swiss-Prot:O32158" /translation="MIKIDIPAPNVTITERQQSANDNEPKIKPIHGFIDFHQIPRDKG GIFMFYNIHDELLFVGKARKLRQRIKKHFEDTVSPIKHHRDEVYKIEVCVVDDPMERE IYETYIINTQHSKYNIDKVFFK*" /label="yurQ CDS" gene complement(2976635..2977009) /gene="yurQ" /locus_tag="BSU_32620" /old_locus_tag="BSU32620" /label="yurQ gene" upshifts complement(2977073) /Source="Nicolas_upshifts" /id="U2558" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.765234765234765" /psig="0.765234765234765" /xcortree=807 /SigmaFactorBS="tccagccggagcacttgcataaTAAGTAAgagcatgacaaac AAATATAATAAAgctgttctagcttttcttttctgtatgtgttagcatttatctttaa t" /listShort="yurQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2977080..2977091) /Source="Nicolas_upshift_promotors" /id="U2558" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.765234765234765" /psig="0.765234765234765" /xcortree=807 /SigmaFactorBS="tccagccggagcacttgcataaTAAGTAAgagcatgacaaac AAATATAATAAAgctgttctagcttttcttttctgtatgtgttagcatttatctttaa t" /listShort="yurQ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2977105..2977111) /Source="Nicolas_upshift_promotors" /id="U2558" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.765234765234765" /psig="0.765234765234765" /xcortree=807 /SigmaFactorBS="tccagccggagcacttgcataaTAAGTAAgagcatgacaaac AAATATAATAAAgctgttctagcttttcttttctgtatgtgttagcatttatctttaa t" /listShort="yurQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2977112..2978230) /gene="dadA" /locus_tag="BSU_32630" /old_locus_tag="BSU32630" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 13914427, 16245349, 22271930, 24826896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-amino acid oxidase" /protein_id="NP_391143.1" /db_xref="EnsemblGenomes-Gn:BSU32630" /db_xref="EnsemblGenomes-Tr:CAB15253" /db_xref="GOA:O32159" /db_xref="InterPro:IPR006076" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG14004" /db_xref="UniProtKB/Swiss-Prot:O32159" /translation="MKSYIIVGAGILGASTAYHLAKTGARVTVIDRKEPGQATDAAAG IVCPWLSQRRNQDWYQLAKGGARYYKDLIHQLEKDGESDTGYKRVGAISIHTDASKLD KMEERAYKRREDAPEIGDITRLSASETKKLFPILADGYESVHISGAARVNGRALCRSL LSAAEKRGATVIKGNASLLFENGTVTGVQTDTKQFAADAVIVTAGAWANEILKPLGIH FQVSFQKAQIMHFEMTDADTGSWPVVMPPSDQYILSFDNGRIVAGATHENDAGLDDLR VTAGGQHEVLSKALAVAPGLADAAAVETRVGFRPFTPGFLPVVGAVPNVQGLYAANGL GASGLTMGPFLGAELAKLVLGKQTELDLSPYDPAGALA*" /label="dadA CDS" gene complement(2977112..2978230) /gene="dadA" /locus_tag="BSU_32630" /old_locus_tag="BSU32630" /label="dadA gene" promotor_-10 complement(2978255..2978274) /Source="Nicolas_upshift_promotors" /id="U2559" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=1879 /SigmaFactorBS="tcgcggtttttccacattagggcaaaaGGTCGAAggaaagca tttgaTTTGGTAAAATGAATAGACAttataatagaaaaggtgtttgcatatgaaatcg t" /listShort="yurR, yurQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2978261) /Source="Nicolas_upshifts" /id="U2559" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=1879 /SigmaFactorBS="tcgcggtttttccacattagggcaaaaGGTCGAAggaaagca tttgaTTTGGTAAAATGAATAGACAttataatagaaaaggtgtttgcatatgaaatcg t" /listShort="yurR, yurQ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2978263..2978873) /Source="Nicolas_S_feature" /locus_tag="new_3353940_3354550_c" /HighExp="G135, H2O2, G180, Paraq, G150, Oxctl, LBGexp, Salt, dia15, Diami" /AntisenseName="yurS" /AntisenseCor="-0.14245591415946501" /AntisenseRegPval="-1.7" /CDS_PredictionProba="0.95340499999999995" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S1255" promotor_-35 complement(2978288..2978294) /Source="Nicolas_upshift_promotors" /id="U2559" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=1879 /SigmaFactorBS="tcgcggtttttccacattagggcaaaaGGTCGAAggaaagca tttgaTTTGGTAAAATGAATAGACAttataatagaaaaggtgtttgcatatgaaatcg t" /listShort="yurR, yurQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2978327..2978336 /Source="Nicolas_upshift_promotors" /id="U2560" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=1408 /SigmaFactorBS="cttttgccctaatgtggaaaaaccgcgaagttcGTCCAATCT CtttactctcctatCGAATATCCTGTCACTATCAatagagaaaggatgataccatgag c" /listShort="sspG, yurS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2978350..2978369 /Source="Nicolas_upshift_promotors" /id="U2560" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=1408 /SigmaFactorBS="cttttgccctaatgtggaaaaaccgcgaagttcGTCCAATCT CtttactctcctatCGAATATCCTGTCACTATCAatagagaaaggatgataccatgag c" /listShort="sspG, yurS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2978354 /Source="Nicolas_upshifts" /id="U2560" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=1408 /SigmaFactorBS="cttttgccctaatgtggaaaaaccgcgaagttcGTCCAATCT CtttactctcctatCGAATATCCTGTCACTATCAatagagaaaggatgataccatgag c" /listShort="sspG, yurS" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2978367..2978382) /Source="Nicolas_upshift_promotors" /id="U2561" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.966033966033966" /psig="0.026973026973027" /xcortree=688 /SigmaFactorBS="catcgcgtctgttttcttcattttcatgacgattttcgCTCA TggtatcATCCTTTCTCTATTGAtagtgacaggatattcgataggagagtaaagagat t" /listShort="yurR, yurQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2978371) /Source="Nicolas_upshifts" /id="U2561" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.966033966033966" /psig="0.026973026973027" /xcortree=688 /SigmaFactorBS="catcgcgtctgttttcttcattttcatgacgattttcgCTCA TggtatcATCCTTTCTCTATTGAtagtgacaggatattcgataggagagtaaagagat t" /listShort="yurR, yurQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2978389..2978393) /Source="Nicolas_upshift_promotors" /id="U2561" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.966033966033966" /psig="0.026973026973027" /xcortree=688 /SigmaFactorBS="catcgcgtctgttttcttcattttcatgacgattttcgCTCA TggtatcATCCTTTCTCTATTGAtagtgacaggatattcgataggagagtaaagagat t" /listShort="yurR, yurQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2978389..2978535 /gene="sspG" /locus_tag="BSU_32640" /old_locus_tag="BSU32640" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9852018" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9852018; Product type f : factor" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="YP_054592.1" /db_xref="EnsemblGenomes-Gn:BSU32640" /db_xref="EnsemblGenomes-Tr:CAE01466" /db_xref="GOA:Q7WY59" /db_xref="SubtiList:BG14173" /db_xref="UniProtKB/Swiss-Prot:Q7WY59" /translation="MSENRHENEENRRDAAVAKVQNSGNAKVVVSVNTDQDQAQAQSQ DGED*" /label="sspG CDS" gene 2978389..2978535 /gene="sspG" /locus_tag="BSU_32640" /old_locus_tag="BSU32640" /label="sspG gene" CDS 2978535..2978810 /gene="yurS" /locus_tag="BSU_32650" /old_locus_tag="BSU32650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 9852018" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391144.1" /db_xref="EnsemblGenomes-Gn:BSU32650" /db_xref="EnsemblGenomes-Tr:CAB15254" /db_xref="SubtiList:BG14005" /db_xref="UniProtKB/Swiss-Prot:O32160" /translation="MNENIIPLNRHTQEIPTTESVIKNSGNSEVHIDIHIDTMPIAFA ILCSALAAKQMTKEEFDMAYTQLREMNRENNSRSSVKQIINQETEEE*" /label="yurS CDS" gene 2978535..2978810 /gene="yurS" /locus_tag="BSU_32650" /old_locus_tag="BSU32650" /label="yurS gene" upshifts complement(2978679) /Source="Nicolas_upshifts" /id="U2562" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.954045954045954" /psig="0.011988011988012" /xcortree=692 /SigmaFactorBS="ctcgcaattgagtataaGCCATatcgaattCCTCTTTTGTCA TCTgctttgcggctaatgcagagcataatatagcaaaagcaattggcattgtatcaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2978695..2978709) /Source="Nicolas_upshift_promotors" /id="U2562" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.954045954045954" /psig="0.011988011988012" /xcortree=692 /SigmaFactorBS="ctcgcaattgagtataaGCCATatcgaattCCTCTTTTGTCA TCTgctttgcggctaatgcagagcataatatagcaaaagcaattggcattgtatcaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2978718..2978722) /Source="Nicolas_upshift_promotors" /id="U2562" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.954045954045954" /psig="0.011988011988012" /xcortree=692 /SigmaFactorBS="ctcgcaattgagtataaGCCATatcgaattCCTCTTTTGTCA TCTgctttgcggctaatgcagagcataatatagcaaaagcaattggcattgtatcaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2978790 /Source="Nicolas_upshifts" /id="D1691" /incds=0 /nref=36 /ntot=86 /MaxReadThrough="1.84089" /MaxDrop="7.4989" /score="15.0184762" /energy="-11" /TU="NA" /idTUdmin="U2560" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" CDS complement(2978874..2979257) /gene="glxB" /locus_tag="BSU_32660" /old_locus_tag="BSU32660" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10882093, 24330391" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10882093, 24330391; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylglyoxalase; lactoylbacillithiol lyase" /protein_id="NP_391145.1" /db_xref="EnsemblGenomes-Gn:BSU32660" /db_xref="EnsemblGenomes-Tr:CAB15255" /db_xref="GOA:O32161" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG14006" /db_xref="UniProtKB/Swiss-Prot:O32161" /translation="MKIVVTSIFVQDQDMALEFYTEKLGFIKKEDVPMGKFRWITLVS PDDQDGTELLLEPNEHPAAKEYQKKIFSEGLPATMFGVADIQKEYNRLKEKGVTFTTE PTKMGEVTIAVFDDTCGNLIQIVQK*" /label="glxB CDS" gene complement(2978874..2979257) /gene="glxB" /locus_tag="BSU_32660" /old_locus_tag="BSU32660" /label="glxB gene" S_feature complement(2979258..2979367) /Source="Nicolas_S_feature" /locus_tag="new_3354935_3355044_c" /HighExp="Salt, G180, H2O2, Paraq, G135, G150, LBGexp, LBGstat, dia15, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S1256" CDS complement(2979368..2979646) /gene="yuzN" /locus_tag="BSU_32669" /old_locus_tag="BSU32669" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="YP_003097781.1" /db_xref="EnsemblGenomes-Gn:BSU32669" /db_xref="EnsemblGenomes-Tr:CAX52687" /db_xref="GOA:C0H3Q8" /db_xref="InterPro:IPR001845" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="UniProtKB/Swiss-Prot:C0H3Q8" /translation="MNGNKDAIFKALGDSTRRLILDELSERNELTLYELTIRLITKYD LSITRQAIAKHLSVLEDAGLVTSKRKGKYRVLIFNNEPLKNLLKGWIE*" /label="yuzN CDS" gene complement(2979368..2979646) /gene="yuzN" /locus_tag="BSU_32669" /old_locus_tag="BSU32669" /label="yuzN gene" promotor_-10 complement(2979644..2979663) /Source="Nicolas_upshift_promotors" /id="U2563" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=2701 /SigmaFactorBS="ggataggttcagtttctatatcacgcaaccatacagttgctt aTACTTGACatgcaactaatgggTTGCTTATACTCAATATATGaatgggaacaaagac g" /listShort="yuzN, S1256, yurT, S1255, yurR, yurQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2979668) /Source="Nicolas_upshifts" /id="U2563" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=2701 /SigmaFactorBS="ggataggttcagtttctatatcacgcaaccatacagttgctt aTACTTGACatgcaactaatgggTTGCTTATACTCAATATATGaatgggaacaaagac g" /listShort="yuzN, S1256, yurT, S1255, yurR, yurQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2979678..2979685) /Source="Nicolas_upshift_promotors" /id="U2563" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=2701 /SigmaFactorBS="ggataggttcagtttctatatcacgcaaccatacagttgctt aTACTTGACatgcaactaatgggTTGCTTATACTCAATATATGaatgggaacaaagac g" /listShort="yuzN, S1256, yurT, S1255, yurR, yurQ" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2979809..2979915) /Source="Nicolas_S_feature" /locus_tag="new_3355486_3355592_c" /HighExp="Sw, BI, LPhT, C90, BC, M0t45, Gly, Cold, H2O2, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 0.994" /TUlongSig="SigGF" /TUlongPSig="0.999" /label="S1257" downshifts complement(2979852) /Source="Nicolas_upshifts" /id="D1692" /incds=0 /nref=189 /ntot=303 /MaxReadThrough="3.22318" /MaxDrop="7.82118" /score="0.760415296" /energy="-10.1" /TU="U2564" /idTUdmin="U2565" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(2979916..2981313) /gene="sufB" /locus_tag="BSU_32670" /old_locus_tag="BSU32670" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 16109955, 16431905, 16621837, 20097860" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16109955, 16431905, 16621837, 20097860; Product type f: factor" /codon_start=1 /transl_table=11 /product="FeS cluster formation scaffold protein" /protein_id="NP_391146.1" /db_xref="EnsemblGenomes-Gn:BSU32670" /db_xref="EnsemblGenomes-Tr:CAB15256" /db_xref="GOA:O32162" /db_xref="InterPro:IPR000825" /db_xref="InterPro:IPR010231" /db_xref="SubtiList:BG14007" /db_xref="UniProtKB/Swiss-Prot:O32162" /translation="MAKKMPDIGEYKYGFHDKDVSIFRSERGLTKEIVEEISRMKEEP QWMLDFRLKSLEHFYNMPMPQWGGDLNSLNFDEITYYVKPSERSERSWDEVPEEIKQT FDKLGIPEAEQKYLAGVSAQYESEVVYHNMKEDLEAQGIVFKDTDSALKENEDIFREH WAKVIPPTDNKFAALNSAVWSGGSFIYVPKGVKVETPLQAYFRINSENMGQFERTLII VDEEASVHYVEGCTAPVYTTNSLHSAVVEIIVKKGGYCRYTTIQNWANNVYNLVTKRT VCEENATMEWIDGNIGSKLTMKYPACILKGEGARGMTLSIALAGKGQHQDAGAKMIHL APNTSSTIVSKSISKQGGKVTYRGIVHFGRKAEGARSNIECDTLIMDNKSTSDTIPYN EILNDNISLEHEAKVSKVSEEQLFYLMSRGISEEEATEMIVMGFIEPFTKELPMEYAV EMNRLIKFEMEGSIG*" /label="sufB CDS" gene complement(2979916..2981313) /gene="sufB" /locus_tag="BSU_32670" /old_locus_tag="BSU32670" /label="sufB gene" downshifts 2981111 /Source="Nicolas_upshifts" /id="D1693" /incds=1 /nref=1 /ntot=150 /MaxReadThrough="2.66718" /MaxDrop="3.75483" /score="-4.89805724" /energy="-5" /TU="NA" /idTUdmin="U2560" /TUdmin=2310 /isTUend="FALSE" /label="downshifts" CDS complement(2981334..2981777) /gene="sufU" /locus_tag="BSU_32680" /old_locus_tag="BSU32680" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 16877383, 20097860, 21236255, 24321018, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16877383, 20097860, 21236255, 24321018, 22720735; Product type f : factor" /codon_start=1 /transl_table=11 /product="iron-sulfur cluster assembly sulfur-transfer protein (Zn(2+)-dependent)" /protein_id="NP_391147.1" /db_xref="EnsemblGenomes-Gn:BSU32680" /db_xref="EnsemblGenomes-Tr:CAB15257" /db_xref="GOA:O32163" /db_xref="InterPro:IPR002871" /db_xref="PDB:1XJS" /db_xref="PDB:2AZH" /db_xref="SubtiList:BG14008" /db_xref="UniProtKB/Swiss-Prot:O32163" /translation="MSFNANLDTLYRQVIMDHYKNPRNKGVLNDSIVVDMNNPTCGDR IRLTMKLDGDIVEDAKFEGEGCSISMASASMMTQAIKGKDIETALSMSKIFSDMMQGK EYDDSIDLGDIEALQGVSKFPARIKCATLSWKALEKGVAKEEGGN*" /label="sufU CDS" gene complement(2981334..2981777) /gene="sufU" /locus_tag="BSU_32680" /old_locus_tag="BSU32680" /label="sufU gene" CDS complement(2981767..2982987) /gene="sufS" /locus_tag="BSU_32690" /old_locus_tag="BSU32690" /EC_number="2.8.1.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 12876288, 14644425, 15901727, 20822158, 21236255, 27382962" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 12876288, 14644425, 15901727, 20822158, 21236255, 27382962; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cysteine desulfurase" /protein_id="NP_391148.1" /db_xref="EnsemblGenomes-Gn:BSU32690" /db_xref="EnsemblGenomes-Tr:CAB15258" /db_xref="GOA:O32164" /db_xref="InterPro:IPR000192" /db_xref="InterPro:IPR010970" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR016454" /db_xref="InterPro:IPR020578" /db_xref="PDB:5J8Q" /db_xref="SubtiList:BG14009" /db_xref="UniProtKB/Swiss-Prot:O32164" /translation="MNITDIREQFPILHQQVNGHDLVYLDSAATSQKPRAVIETLDKY YNQYNSNVHRGVHTLGTRATDGYEGAREKVRKFINAKSMAEIIFTKGTTTSLNMVALS YARANLKPGDEVVITYMEHHANIIPWQQAVKATGATLKYIPLQEDGTISLEDVRETVT SNTKIVAVSHVSNVLGTVNPIKEMAKIAHDNGAVIVVDGAQSTPHMKIDVQDLDCDFF ALSSHKMCGPTGVGVLYGKKALLENMEPAEFGGEMIDFVGLYESTWKELPWKFEAGTP IIAGAIGLGAAIDFLEEIGLDEISRHEHKLAAYALERFRQLDGVTVYGPEERAGLVTF NLDDVHPHDVATVLDAEGIAVRAGHHCAQPLMKWLDVTATARASFYLYNTEEEIDKLV EALQKTKEYFTNVF*" /label="sufS CDS" gene complement(2981767..2982987) /gene="sufS" /locus_tag="BSU_32690" /old_locus_tag="BSU32690" /label="sufS gene" CDS complement(2982987..2984300) /gene="sufD" /locus_tag="BSU_32700" /old_locus_tag="BSU32700" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 16109955, 16431905, 16621837, 19187533, 20097860, 28839209; Product type f: factor" /codon_start=1 /transl_table=11 /product="Fe-S cluster assembly protein SufD" /protein_id="NP_391149.1" /db_xref="EnsemblGenomes-Gn:BSU32700" /db_xref="EnsemblGenomes-Tr:CAB15259" /db_xref="GOA:O32165" /db_xref="InterPro:IPR000825" /db_xref="InterPro:IPR011542" /db_xref="SubtiList:BG14010" /db_xref="UniProtKB/Swiss-Prot:O32165" /translation="MTLGTKLSVDQEYLKSFSEKHQEPAWLKNLRLQALEQAEDLPMP KPDKTKITNWNFTNFAKHTVDNEPLSSLEDLTDEVKALIDIENEDKTLYVQRDQTPAH LSLSQELKDKGVIFTDILTAAREHSDLVEKYFMKDGVKVDEHKLTALHAALVNGGAFL YVPKNVQVETPVQAVYVHESNDTALFNHVLIVAEDHSSVTYVENYISTVNPKDAVFNI ISEVITGDNASVTYGAVDNLSSGVTTYVNRRGAARGRDSKIEWALGLMNDGDTISENT TNLYGDGTYGDTKTVVVGRGEQTENFTTQIIHFGKASEGYILKHGVMKDSASSIFNGI GKIEHGASKANAEQESRVLMLSEKARGDANPILLIDEDDVTAGHAASVGRVDPIQLYY LMSRGIPKEEAERLVIYGFLAPVVNELPIEGVKKQLVSVIERKVK*" /label="sufD CDS" gene complement(2982987..2984300) /gene="sufD" /locus_tag="BSU_32700" /old_locus_tag="BSU32700" /label="sufD gene" CDS complement(2984318..2985103) /gene="sufC" /locus_tag="BSU_32710" /old_locus_tag="BSU32710" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 16431905, 20097860, 28839209" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16431905, 20097860, 28839209; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sulfur mobilizing ABC protein, ATPase" /protein_id="NP_391150.1" /db_xref="EnsemblGenomes-Gn:BSU32710" /db_xref="EnsemblGenomes-Tr:CAB15260" /db_xref="GOA:P80866" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR010230" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG14011" /db_xref="UniProtKB/Swiss-Prot:P80866" /translation="MAASTLTIKDLHVEIEGKEILKGVNLEIKGGEFHAVMGPNGTGK STLSAAIMGHPKYEVTKGSITLDGKDVLEMEVDERAQAGLFLAMQYPSEISGVTNADF LRSAINARREEGDEISLMKFIRKMDENMEFLEMDPEMAQRYLNEGFSGGEKKRNEILQ LMMIEPKIAILDEIDSGLDIDALKVVSKGINKMRSENFGCLMITHYQRLLNYITPDVV HVMMQGRVVKSGGAELAQRLEAEGYDWIKQELGIEDETVGQEA*" /label="sufC CDS" gene complement(2984318..2985103) /gene="sufC" /locus_tag="BSU_32710" /old_locus_tag="BSU32710" /label="sufC gene" promotor_-10 complement(2985147..2985166) /Source="Nicolas_upshift_promotors" /id="U2564" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.658341658341658" /psig=1 /xcortree=2086 /SigmaFactorBS="gaatgtgcaaggcacgataaaAAGTTGTAtttacttttcatt TGTTATAAAATTAGAATGAGaataaaatgagaataatgattatatatttttggaggta t" /listShort="sufC, sufD, sufS, iscU, sufB, S1257" /listLong="yuzN, S1256, yurT, S1255, yurR, yurQ" /label="promotor_-10" upshifts complement(2985148) /Source="Nicolas_upshifts" /id="U2564" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.658341658341658" /psig=1 /xcortree=2086 /SigmaFactorBS="gaatgtgcaaggcacgataaaAAGTTGTAtttacttttcatt TGTTATAAAATTAGAATGAGaataaaatgagaataatgattatatatttttggaggta t" /listShort="sufC, sufD, sufS, iscU, sufB, S1257" /listLong="yuzN, S1256, yurT, S1255, yurR, yurQ" /label="upshifts" promotor_-35 complement(2985180..2985187) /Source="Nicolas_upshift_promotors" /id="U2564" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.658341658341658" /psig=1 /xcortree=2086 /SigmaFactorBS="gaatgtgcaaggcacgataaaAAGTTGTAtttacttttcatt TGTTATAAAATTAGAATGAGaataaaatgagaataatgattatatatttttggaggta t" /listShort="sufC, sufD, sufS, iscU, sufB, S1257" /listLong="yuzN, S1256, yurT, S1255, yurR, yurQ" /label="promotor_-35" promotor_-10 complement(2985204..2985223) /Source="Nicolas_upshift_promotors" /id="U2565" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.829170829170829" /psig=1 /xcortree=2486 /SigmaFactorBS="gtgggaatccactctttttctttttcaatcGCTTTaataaag tgctgatcTTTGTTAAACTTGAGGAATGtgcaaggcacgataaaaagttgtatttact t" /listShort="sufC, sufD, sufS, iscU, sufB, S1257" /listLong="yuzN, S1256, yurT, S1255, yurR, yurQ" /label="promotor_-10" upshifts complement(2985213) /Source="Nicolas_upshifts" /id="U2565" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.829170829170829" /psig=1 /xcortree=2486 /SigmaFactorBS="gtgggaatccactctttttctttttcaatcGCTTTaataaag tgctgatcTTTGTTAAACTTGAGGAATGtgcaaggcacgataaaaagttgtatttact t" /listShort="sufC, sufD, sufS, iscU, sufB, S1257" /listLong="yuzN, S1256, yurT, S1255, yurR, yurQ" /label="upshifts" S_feature complement(2985215..2985296) /Source="Nicolas_S_feature" /locus_tag="new_3360892_3360973_c" /HighExp="Salt, HiOs, B60, LoTm, T1.0H, Gly, T2.0H, C30, Etha, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF" /TUshortPSig="0.994, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1258" promotor_-35 complement(2985239..2985243) /Source="Nicolas_upshift_promotors" /id="U2565" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.829170829170829" /psig=1 /xcortree=2486 /SigmaFactorBS="gtgggaatccactctttttctttttcaatcGCTTTaataaag tgctgatcTTTGTTAAACTTGAGGAATGtgcaaggcacgataaaaagttgtatttact t" /listShort="sufC, sufD, sufS, iscU, sufB, S1257" /listLong="yuzN, S1256, yurT, S1255, yurR, yurQ" /label="promotor_-35" misc_RNA complement(2985260..2985507) /gene="bsrI" /locus_tag="BSU_misc_RNA_84" /product="small regulatory RNA or messenger RNA" /experiment="publication(s) with functional evidences, PMID:18948176" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18948176; Product type n: RNA" /label="bsrI RNA" gene complement(2985260..2985507) /gene="bsrI" /locus_tag="BSU_misc_RNA_84" /label="bsrI gene" CDS complement(2985297..2985434) /gene="yuzK" /locus_tag="BSU_32719" /old_locus_tag="BSU32719" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative toxin of a toxin antitoxin system" /protein_id="YP_003097782.1" /db_xref="EnsemblGenomes-Gn:BSU32719" /db_xref="EnsemblGenomes-Tr:CAX52688" /db_xref="UniProtKB/Swiss-Prot:C0H3Q9" /translation="MEKAMQLSHGIGYEEYGRRLETRMKVERQRELDYEKSKRISAGA Y*" /label="yuzK CDS" gene complement(2985297..2985434) /gene="yuzK" /locus_tag="BSU_32719" /old_locus_tag="BSU32719" /label="yuzK gene" S_feature complement(2985435..2985519) /Source="Nicolas_S_feature" /locus_tag="new_3361112_3361196_c" /HighExp="HiOs, Salt, B60, S5, T1.0H, S8, HiTm, S7, T1.30H, Etha" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.63415999999999995" /TUshortSig="SigA, SigGF" /TUshortPSig="0.994, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1259" promotor_-10 complement(2985503..2985522) /Source="Nicolas_upshift_promotors" /id="U2566" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.437562437562438" /psig="0.994005994005994" /xcortree=2864 /SigmaFactorBS="tttcgtctcatctgccgctatttcacgccaaatcgtttTTGC ggcatccaacgcagcACTGGTACAATAAAAAGCAAatatatgaagggattgattcatt a" /listShort="S1259, yuzK, S1258, sufC, sufD, sufS, iscU, sufB, S1257" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2985519) /Source="Nicolas_upshifts" /id="U2566" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.437562437562438" /psig="0.994005994005994" /xcortree=2864 /SigmaFactorBS="tttcgtctcatctgccgctatttcacgccaaatcgtttTTGC ggcatccaacgcagcACTGGTACAATAAAAAGCAAatatatgaagggattgattcatt a" /listShort="S1259, yuzK, S1258, sufC, sufD, sufS, iscU, sufB, S1257" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2985521..2985627) /Source="Nicolas_S_feature" /locus_tag="new_3361198_3361304_c" /HighExp="S8, S5, S7, S6, S4, BT, ferm, nit, S3, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1260" promotor_-35 complement(2985538..2985541) /Source="Nicolas_upshift_promotors" /id="U2566" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.437562437562438" /psig="0.994005994005994" /xcortree=2864 /SigmaFactorBS="tttcgtctcatctgccgctatttcacgccaaatcgtttTTGC ggcatccaacgcagcACTGGTACAATAAAAAGCAAatatatgaagggattgattcatt a" /listShort="S1259, yuzK, S1258, sufC, sufD, sufS, iscU, sufB, S1257" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2985628..2986005) /gene="yurZ" /locus_tag="BSU_32720" /old_locus_tag="BSU32720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391151.1" /db_xref="EnsemblGenomes-Gn:BSU32720" /db_xref="EnsemblGenomes-Tr:CAB15261" /db_xref="GOA:O32166" /db_xref="InterPro:IPR003779" /db_xref="InterPro:IPR029032" /db_xref="SubtiList:BG14012" /db_xref="UniProtKB/Swiss-Prot:O32166" /translation="MEGFSLNQDRGSMQDALKQYKHGLGTFEQKMPLMGRKFNEFTEQ CFAGNSLTEREKQLIALGIAINAQDEYCMIYHTKGCLDQGASEENILEAVSVAAAFGG GAAFSQGVTVVQQCIEEFGNTTH*" /label="yurZ CDS" gene complement(2985628..2986005) /gene="yurZ" /locus_tag="BSU_32720" /old_locus_tag="BSU32720" /label="yurZ gene" promotor_-10 complement(2986022..2986033) /Source="Nicolas_upshift_promotors" /id="U2567" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=935 /SigmaFactorBS="actgaaaccccggatgagaattccggggtttttttCGCGTAT tttcctaaaagctGTTCATAATAAAaaggaatgttaaacagatggagggattttcttt g" /listShort="yurZ, S1260, S1259, yuzK, S1258" /listLong="sufC, sufD, sufS, iscU, sufB, S1257" /label="promotor_-10" upshifts complement(2986028) /Source="Nicolas_upshifts" /id="U2567" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=935 /SigmaFactorBS="actgaaaccccggatgagaattccggggtttttttCGCGTAT tttcctaaaagctGTTCATAATAAAaaggaatgttaaacagatggagggattttcttt g" /listShort="yurZ, S1260, S1259, yuzK, S1258" /listLong="sufC, sufD, sufS, iscU, sufB, S1257" /label="upshifts" promotor_-35 complement(2986047..2986053) /Source="Nicolas_upshift_promotors" /id="U2567" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=935 /SigmaFactorBS="actgaaaccccggatgagaattccggggtttttttCGCGTAT tttcctaaaagctGTTCATAATAAAaaggaatgttaaacagatggagggattttcttt g" /listShort="yurZ, S1260, S1259, yuzK, S1258" /listLong="sufC, sufD, sufS, iscU, sufB, S1257" /label="promotor_-35" CDS complement(2986090..2986914) /gene="metQ" /locus_tag="BSU_32730" /old_locus_tag="BSU32730" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10094622, 12910260, 14990259, 16109943, 17038623" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12910260, 14990259, 16109943, 17038623; Product type t : transporter" /codon_start=1 /transl_table=11 /product="methionine ABC transporter, substrate binding lipoprotein" /protein_id="NP_391152.1" /db_xref="EnsemblGenomes-Gn:BSU32730" /db_xref="EnsemblGenomes-Tr:CAB15262" /db_xref="GOA:O32167" /db_xref="InterPro:IPR004872" /db_xref="PDB:4GOT" /db_xref="SubtiList:BG14013" /db_xref="UniProtKB/Swiss-Prot:O32167" /translation="MKKLFLGALLLVFAGVMAACGSNNGAESGKKEIVVAATKTPHAE ILKEAEPLLKEKGYTLKVKVLSDYKMYNKALADKEVDANYFQHIPYLEQEMKENTDYK LVNAGAVHLEPFGIYSKTYKSLKDLPDGATIILTNNVAEQGRMLAMLENAGLITLDSK VETVDATLKDIKKNPKNLEFKKVAPELTAKAYENKEGDAVFINVNYAIQNKLNPKKDA IEVESTKNNPYANIIAVRKGEEDSAKIKALMEVLHSKKIKDFIEKKYDGAVLPVSE*" /label="metQ CDS" gene complement(2986090..2986914) /gene="metQ" /locus_tag="BSU_32730" /old_locus_tag="BSU32730" /label="metQ gene" downshifts complement(2986098) /Source="Nicolas_upshifts" /id="D1694" /incds=0 /nref=167 /ntot=246 /MaxReadThrough="2.13581" /MaxDrop="6.33517" /score="28.8468637" /energy="-12.6" /TU="NA" /idTUdmin="U2569" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" downshifts complement(2986247) /Source="Nicolas_upshifts" /id="D1695" /incds=1 /nref=2 /ntot=171 /MaxReadThrough="6.93658" /MaxDrop="2.3341" /score="28.8468637" /energy="-12.6" /TU="U2569" /idTUdmin="U2569" /TUdmin="-154" /isTUend="FALSE" /label="downshifts" promotor_-35 2986274..2986279 /Source="Nicolas_upshift_promotors" /id="U2568" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1218 /SigmaFactorBS="gtttttcgttgattctacttcaattgcgtcttttttaGGATT TaatttattttggatcGCATAGTTTACATTGATGAagaccgcgtctccttctttgttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2986295..2986313 /Source="Nicolas_upshift_promotors" /id="U2568" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1218 /SigmaFactorBS="gtttttcgttgattctacttcaattgcgtcttttttaGGATT TaatttattttggatcGCATAGTTTACATTGATGAagaccgcgtctccttctttgttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2986297 /Source="Nicolas_upshifts" /id="U2568" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1218 /SigmaFactorBS="gtttttcgttgattctacttcaattgcgtcttttttaGGATT TaatttattttggatcGCATAGTTTACATTGATGAagaccgcgtctccttctttgttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2986928..2987596) /gene="metP" /locus_tag="BSU_32740" /old_locus_tag="BSU32740" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10094622, 12910260, 14990259, 15849754, 16850406, 17038623" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12910260, 14990259, 15849754, 16850406, 17038623; Product type t : transporter" /codon_start=1 /transl_table=11 /product="methionine ABC transporter, permease component" /protein_id="NP_391153.1" /db_xref="EnsemblGenomes-Gn:BSU32740" /db_xref="EnsemblGenomes-Tr:CAB15263" /db_xref="GOA:O32168" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG14014" /db_xref="UniProtKB/Swiss-Prot:O32168" /translation="MFEKYFPNVDLTELWNATYETLYMTLISLLFAFVIGVILGLLLF LTSKGSLWQNKAVNSVIAAVVNIFRSIPFLILIILLLGFTKFLVGTILGPNAALPALV IGSAPFYARLVEIALREVDKGVIEAAKSMGAKTSTIIFKVLIPESMPALISGITVTAI ALIGSTAIAGAIGSGGLGNLAYVEGYQSNNADVTFVATVFILIIVFIIQIIGDLITNI IDKR*" /label="metP CDS" gene complement(2986928..2987596) /gene="metP" /locus_tag="BSU_32740" /old_locus_tag="BSU32740" /label="metP gene" CDS complement(2987589..2988614) /gene="metN" /locus_tag="BSU_32750" /old_locus_tag="BSU32750" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10094622, 12910260, 14990259, 17038623" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12910260, 14990259, 17038623; Product type t: transporter" /codon_start=1 /transl_table=11 /product="methionine ABC transporter (ATP-binding protein)" /protein_id="NP_391154.1" /db_xref="EnsemblGenomes-Gn:BSU32750" /db_xref="EnsemblGenomes-Tr:CAB15264" /db_xref="GOA:O32169" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR017908" /db_xref="InterPro:IPR018449" /db_xref="InterPro:IPR026253" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG14015" /db_xref="UniProtKB/Swiss-Prot:O32169" /translation="MINLQDVSKVYKSKHGDVNAVQNVSLSIKKGEIFGIIGYSGAGK SSLIRLLNGLEKPTSGTVEVAGTKINEVNGRGLRKARHEISMIFQHFNLLWSRTVRDN IMFPLEIAGVKKSERIKRANELIKLVGLEGKEKSYPSQLSGGQKQRVGIARALANNPK VLLCDEATSALDPQTTDSILDLLSDINERLGLTIVLITHEMHVIRKICNRVAVMENGK VVEEGEVLDVFKNPKEQMTKRFVQQVTEPEETKETLQHLLDDTASGKMVQLTFVGESA EQPLITEMIRNFNVSVNILQGKISQTKDGAYGSLFIHIDGDEEEVQNVIRFINDKQVK AEVITNV*" /label="metN CDS" gene complement(2987589..2988614) /gene="metN" /locus_tag="BSU_32750" /old_locus_tag="BSU32750" /label="metN gene" S_feature complement(2988615..2988719) /Source="Nicolas_S_feature" /locus_tag="new_3364292_3364396_c" /HighExp="MG 5, MG t5, MG 10, BMM, MG-0.2, GM 25, MG-0.1, MG 15, M9-exp, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.996" /TUlongSig="SigA" /TUlongPSig="0.999" /label="S1261" misc_RNA complement(2988720..2988826) /gene="mswH" /locus_tag="BSU_misc_RNA_53" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /function="16.3: Control" /label="mswH RNA" gene complement(2988720..2988826) /gene="mswH" /locus_tag="BSU_misc_RNA_53" /label="mswH gene" downshifts 2988789 /Source="Nicolas_upshifts" /id="D1696" /incds=0 /nref=2 /ntot=37 /MaxReadThrough="1.54417" /MaxDrop="5.51028" /score="-1.70178746" /energy="-11.2" /TU="NA" /idTUdmin="U2568" /TUdmin=2420 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2988853..2988872) /Source="Nicolas_upshift_promotors" /id="U2569" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2424 /SigmaFactorBS="tataatagtaaaagttgacatcatttatttTATTGACAttta atcattcgccgTGCTATTCTACATTAAGAATttccggacgaaaaagactatatatttc t" /listShort="NA, S1261, metQ, metP, metN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2988865) /Source="Nicolas_upshifts" /id="U2569" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2424 /SigmaFactorBS="tataatagtaaaagttgacatcatttatttTATTGACAttta atcattcgccgTGCTATTCTACATTAAGAATttccggacgaaaaagactatatatttc t" /listShort="NA, S1261, metQ, metP, metN" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2988867..2988940) /Source="Nicolas_S_feature" /locus_tag="new_3364544_3364617_c" /HighExp="M9-stat, S2, LoTm, T5.0H, HiOs, B60, S3, T3.30H, LPhT, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.996, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1262" promotor_-35 complement(2988888..2988895) /Source="Nicolas_upshift_promotors" /id="U2569" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2424 /SigmaFactorBS="tataatagtaaaagttgacatcatttatttTATTGACAttta atcattcgccgTGCTATTCTACATTAAGAATttccggacgaaaaagactatatatttc t" /listShort="NA, S1261, metQ, metP, metN" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2988941..2989285) /gene="yusD" /locus_tag="BSU_32760" /old_locus_tag="BSU32760" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391155.1" /db_xref="EnsemblGenomes-Gn:BSU32760" /db_xref="EnsemblGenomes-Tr:CAB15265" /db_xref="InterPro:IPR003033" /db_xref="InterPro:IPR036527" /db_xref="SubtiList:BG14016" /db_xref="UniProtKB/Swiss-Prot:O32170" /translation="MEKAEVLEDEYQHLFLKPLLNASTLLITFQGEAEALTVSINEQG EMKKVSPPQTSNLTFYGNQTEIIDLLHGDISLQHLIQSGSLKVKGSFRALLKLEAILW LTNGFFQRILKN*" /label="yusD CDS" gene complement(2988941..2989285) /gene="yusD" /locus_tag="BSU_32760" /old_locus_tag="BSU32760" /label="yusD gene" S_feature complement(2989286..2989391) /Source="Nicolas_S_feature" /locus_tag="new_3364963_3365068_c" /HighExp="LPhT, HiOs, M9-stat, dia5, T2.0H, Diami, T1.30H, T0.30H, T2.30H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigA, SigA" /TUshortPSig="1, 0.996, 0.999" /TUlongSig="SigA" /TUlongPSig=1 /label="S1263" CDS complement(2989392..2989712) /gene="yusE" /locus_tag="BSU_32770" /old_locus_tag="BSU32770" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15937154, 25875741; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thiol-disulfide oxidoreductase with thioredoxin domain" /protein_id="NP_391156.1" /db_xref="EnsemblGenomes-Gn:BSU32770" /db_xref="EnsemblGenomes-Tr:CAB15266" /db_xref="GOA:O32171" /db_xref="InterPro:IPR005746" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG14017" /db_xref="UniProtKB/Swiss-Prot:O32171" /translation="MKELQEHELDHIEDDVYLLYLYTPFCGTCQLASKMLTVVKEMLP DVAFYQNNVNYSPTFAKAYQIESVPCFLLFKGGKMVERGYAFHSVSYLYELIKQKSSS ASHL*" /label="yusE CDS" gene complement(2989392..2989712) /gene="yusE" /locus_tag="BSU_32770" /old_locus_tag="BSU32770" /label="yusE gene" CDS complement(2989714..2990154) /gene="yusF" /locus_tag="BSU_32780" /old_locus_tag="BSU32780" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12794188; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ribonuclease" /protein_id="NP_391157.1" /db_xref="EnsemblGenomes-Gn:BSU32780" /db_xref="EnsemblGenomes-Tr:CAB15267" /db_xref="GOA:O32172" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR034141" /db_xref="SubtiList:BG14018" /db_xref="UniProtKB/Swiss-Prot:O32172" /translation="MLAVNFTAFFYNLNISNLTRQVNKMKMDELEKVMIVEGKSDKEK IESVLNEPMRIICTNGTISQLRLEELADELYDKDVYILVDADESGEKLRKQLKREFNE ACHLHVDRAYKEVAAAPRHHIASVLLRANLNVHTIFLERKSRGV*" /label="yusF CDS" gene complement(2989714..2990154) /gene="yusF" /locus_tag="BSU_32780" /old_locus_tag="BSU32780" /label="yusF gene" CDS complement(2990154..2990390) /gene="yusG" /locus_tag="BSU_32790" /old_locus_tag="BSU32790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391158.1" /db_xref="EnsemblGenomes-Gn:BSU32790" /db_xref="EnsemblGenomes-Tr:CAB15268" /db_xref="InterPro:IPR020140" /db_xref="SubtiList:BG14019" /db_xref="UniProtKB/Swiss-Prot:O32173" /translation="MAFDKQKLDVTNDVTGRFQNGRLSLYHDNEMIGQMTSMNEYELK SGYSFENEKFYKTADVVSGDDAKYVDCDYENGWC*" /label="yusG CDS" gene complement(2990154..2990390) /gene="yusG" /locus_tag="BSU_32790" /old_locus_tag="BSU32790" /label="yusG gene" downshifts complement(2990166) /Source="Nicolas_upshifts" /id="D1697" /incds=0 /nref=35 /ntot=245 /MaxReadThrough="6.00162" /MaxDrop="3.9147" /score="-1.53913693" /energy="-11" /TU="U2570,U2571,U2572" /idTUdmin="U2574" /TUdmin=723 /isTUend="FALSE" /label="downshifts" upshifts complement(2990405) /Source="Nicolas_upshifts" /id="U2570" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=805 /SigmaFactorBS="agatgacacaagaagactaaaacAGGATAGccgtaaaagcaa ttGGACACGCTAACgttatgggaggtgtccaatatggctttcgacaaacaaaagctcg a" /listShort="yusG, yusF, yusE, S1263, yusD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2990410..2990421) /Source="Nicolas_upshift_promotors" /id="U2570" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=805 /SigmaFactorBS="agatgacacaagaagactaaaacAGGATAGccgtaaaagcaa ttGGACACGCTAACgttatgggaggtgtccaatatggctttcgacaaacaaaagctcg a" /listShort="yusG, yusF, yusE, S1263, yusD" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2990436..2990442) /Source="Nicolas_upshift_promotors" /id="U2570" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=805 /SigmaFactorBS="agatgacacaagaagactaaaacAGGATAGccgtaaaagcaa ttGGACACGCTAACgttatgggaggtgtccaatatggctttcgacaaacaaaagctcg a" /listShort="yusG, yusF, yusE, S1263, yusD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2990446..2990829) /gene="gcvH" /locus_tag="BSU_32800" /old_locus_tag="BSU32800" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 20882995, 21338421; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycine cleavage system protein H (lipoyl acceptor protein)" /protein_id="NP_391159.1" /db_xref="EnsemblGenomes-Gn:BSU32800" /db_xref="EnsemblGenomes-Tr:CAB15269" /db_xref="GOA:O32174" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR002930" /db_xref="InterPro:IPR003016" /db_xref="InterPro:IPR011053" /db_xref="InterPro:IPR017453" /db_xref="InterPro:IPR033753" /db_xref="SubtiList:BG14020" /db_xref="UniProtKB/Swiss-Prot:O32174" /translation="MSIPKDLRYSGEHEWVKVEGEKARIGITHFAQSELGDIVFVELP EVGAEIKADEPFGSVESVKTVSELYAPINGTVVEVNEDLDDSPEFVNESPYEKAWMIV VEPSDASEIEKLMTAEQYEEMTQED*" /label="gcvH CDS" gene complement(2990446..2990829) /gene="gcvH" /locus_tag="BSU_32800" /old_locus_tag="BSU32800" /label="gcvH gene" promotor_-10 complement(2990856..2990875) /Source="Nicolas_upshift_promotors" /id="U2571" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.601398601398601" /psig="0.996003996003996" /xcortree=2237 /SigmaFactorBS="aagaagaccaatttgaagaaaactgggcttaaTGTAAATTtt ttttgaaaagTGTGGTATCTTCTTATTGTAgtgctgtaaaaaatggagggattcaatt g" /listShort="yusH, yusG, yusF, yusE, S1263, yusD, S1262, NA, S1261, metQ" /listLong="metP, metN" /label="promotor_-10" upshifts complement(2990867) /Source="Nicolas_upshifts" /id="U2571" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.601398601398601" /psig="0.996003996003996" /xcortree=2237 /SigmaFactorBS="aagaagaccaatttgaagaaaactgggcttaaTGTAAATTtt ttttgaaaagTGTGGTATCTTCTTATTGTAgtgctgtaaaaaatggagggattcaatt g" /listShort="yusH, yusG, yusF, yusE, S1263, yusD, S1262, NA, S1261, metQ" /listLong="metP, metN" /label="upshifts" promotor_-35 complement(2990888..2990895) /Source="Nicolas_upshift_promotors" /id="U2571" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.601398601398601" /psig="0.996003996003996" /xcortree=2237 /SigmaFactorBS="aagaagaccaatttgaagaaaactgggcttaaTGTAAATTtt ttttgaaaagTGTGGTATCTTCTTATTGTAgtgctgtaaaaaatggagggattcaatt g" /listShort="yusH, yusG, yusF, yusE, S1263, yusD, S1262, NA, S1261, metQ" /listLong="metP, metN" /label="promotor_-35" CDS complement(2990896..2991252) /gene="yusI" /locus_tag="BSU_32810" /old_locus_tag="BSU32810" /EC_number="1.20.4.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase with thioredoxin domain and regulator domain" /protein_id="NP_391160.1" /db_xref="EnsemblGenomes-Gn:BSU32810" /db_xref="EnsemblGenomes-Tr:CAB15270" /db_xref="GOA:O32175" /db_xref="InterPro:IPR006504" /db_xref="InterPro:IPR006660" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG14021" /db_xref="UniProtKB/Swiss-Prot:O32175" /translation="MSLTFYWYPKCGTCRKAKKWLEEHGKEINEIHIAEQPPSKEELK ALYEKSGLDLKKFFNTSGMKYRELNLKEKLYHMSEDEQLELLASDGMLIKRPLTTDGE KVTVGFKEDQFEENWA*" /label="yusI CDS" gene complement(2990896..2991252) /gene="yusI" /locus_tag="BSU_32810" /old_locus_tag="BSU32810" /label="yusI gene" promotor_-10 complement(2991275..2991294) /Source="Nicolas_upshift_promotors" /id="U2572" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.562437562437562" /psig="0.999000999001" /xcortree=2011 /SigmaFactorBS="atgcgcggagctcttttttaagaagcactgttTTAGGTtttt aaaacaaacTGTGTTAAAATAACCTCGATtattttattgagggggaagaagatgtcgt t" /listShort="yusI, yusH, yusG, yusF, yusE, S1263, yusD, S1262" /listLong="NA, S1261, metQ, metP, metN" /label="promotor_-10" upshifts complement(2991285) /Source="Nicolas_upshifts" /id="U2572" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.562437562437562" /psig="0.999000999001" /xcortree=2011 /SigmaFactorBS="atgcgcggagctcttttttaagaagcactgttTTAGGTtttt aaaacaaacTGTGTTAAAATAACCTCGATtattttattgagggggaagaagatgtcgt t" /listShort="yusI, yusH, yusG, yusF, yusE, S1263, yusD, S1262" /listLong="NA, S1261, metQ, metP, metN" /label="upshifts" promotor_-35 complement(2991308..2991313) /Source="Nicolas_upshift_promotors" /id="U2572" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.562437562437562" /psig="0.999000999001" /xcortree=2011 /SigmaFactorBS="atgcgcggagctcttttttaagaagcactgttTTAGGTtttt aaaacaaacTGTGTTAAAATAACCTCGATtattttattgagggggaagaagatgtcgt t" /listShort="yusI, yusH, yusG, yusF, yusE, S1263, yusD, S1262" /listLong="NA, S1261, metQ, metP, metN" /label="promotor_-35" CDS complement(2991363..2993147) /gene="fadE" /locus_tag="BSU_32820" /old_locus_tag="BSU32820" /EC_number="1.3.99.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17189250, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acyl-CoA dehydrogenase (FAD dependent)" /protein_id="NP_391161.1" /db_xref="EnsemblGenomes-Gn:BSU32820" /db_xref="EnsemblGenomes-Tr:CAB15271" /db_xref="GOA:O32176" /db_xref="InterPro:IPR006089" /db_xref="InterPro:IPR006091" /db_xref="InterPro:IPR009075" /db_xref="InterPro:IPR009100" /db_xref="InterPro:IPR013786" /db_xref="InterPro:IPR036250" /db_xref="InterPro:IPR037069" /db_xref="SubtiList:BG14022" /db_xref="UniProtKB/Swiss-Prot:O32176" /translation="MAKKAADVQKGGGFLIEDVTYDQMYTPEDFTDEHKMIAKTTEDY IEQDVLPHIDDIENHQFEHSVRLLKKAGELGLLGADVPEEYGGLGLDKISSALITEKF SRAGSFSLSYGAHVGIGSLPIVFFGSEEQKKKYLPGLASGEKIAAYALTEPGSGSDAL GAKTTAVLNEAGTHYVLTGEKQWITNSAFADVFVVYAKVDGDKFSAFIVEKEFPGVST GPEEKKMGIKGSSTRTLILDQAEVPKENLLGEIGKGHVIAFNILNIGRYKLAVGTIGA SKRVIELSAAYANQRRQFKTPIAGFSLTQEKIGTMASRLYAMESSVYRTVGLFEDNMS QFTAEDLKDGRQIAKSIAEYAIECSLNKVFGSETLDYIVDEGVQIHGGYGFMQEYEVE RAYRDSRINRIFEGTNEINRLIVPSTFLKKALKGELPLFEKAQSLQEELMMLMPEEPG SGVLEQEKYIVKQAKKIALFAAGLAAQKYGKAIDREQEILVNVADIVSNVYAMESAVL RTEKAIAAQGAEKAAQKVLYTEIFVQEAFNEIEAHAKESLIAMEEGDSLRMMLSALRK LTRVTPKNVIQKKREAAAGIFEAEKYTV*" /label="fadE CDS" gene complement(2991363..2993147) /gene="fadE" /locus_tag="BSU_32820" /old_locus_tag="BSU32820" /label="fadE gene" downshifts complement(2991373) /Source="Nicolas_upshifts" /id="D1698" /incds=0 /nref=24 /ntot=46 /MaxReadThrough="4.78872" /MaxDrop="6.88218" /score="31.8022607" /energy="-16.4" /TU="U2574" /idTUdmin="U2576" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2993162..2994337) /gene="fadA" /locus_tag="BSU_32830" /old_locus_tag="BSU32830" /EC_number="2.3.1.16" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17189250, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-CoA C-acyltransferase" /protein_id="NP_391162.1" /db_xref="EnsemblGenomes-Gn:BSU32830" /db_xref="EnsemblGenomes-Tr:CAB15272" /db_xref="GOA:O32177" /db_xref="InterPro:IPR002155" /db_xref="InterPro:IPR016039" /db_xref="InterPro:IPR020610" /db_xref="InterPro:IPR020613" /db_xref="InterPro:IPR020615" /db_xref="InterPro:IPR020616" /db_xref="InterPro:IPR020617" /db_xref="SubtiList:BG14023" /db_xref="UniProtKB/Swiss-Prot:O32177" /translation="MKEAVIVSGARTPVGKAKKGSLATVRPDDLGAICVKETLKRAGG YEGNIDDLIIGCATPEAEQGLNMARNIGALAGLPYTVPAITVNRYCSSGLQSIAYAAE KIMLGAYDTAIAGGAESMSQVPMMGHVTRPNLALAEKAPEYYMSMGHTAEQVAKKYGV SREDQDAFAVRSHQNAAKALAEGKFKDEIVPVEVTVTEIGEDHKPMEKQFVFSQDEGV RPQTTADILSTLRPAFSVDGTVTAGNSSQTSDGAAAVMLMDREKADALGLAPLVKFRS FAVGGVPPEVMGIGPVEAIPRALKLAGLQLQDIGLFELNEAFASQAIQVIRELGIDEE KVNVNGGAIALGHPLGCTGTKLTLSLIHEMKRRNEQFGVVTMCIGGGMGAAGVFELC* " /label="fadA CDS" gene complement(2993162..2994337) /gene="fadA" /locus_tag="BSU_32830" /old_locus_tag="BSU32830" /label="fadA gene" CDS complement(2994348..2996717) /gene="fadN" /locus_tag="BSU_32840" /old_locus_tag="BSU32840" /EC_number="1.1.1.35" /EC_number="4.2.1.17" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 17189250, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase" /protein_id="NP_391163.2" /db_xref="EnsemblGenomes-Gn:BSU32840" /db_xref="EnsemblGenomes-Tr:CAB15273" /db_xref="GOA:O32178" /db_xref="InterPro:IPR001753" /db_xref="InterPro:IPR006108" /db_xref="InterPro:IPR006176" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR029045" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG14024" /db_xref="UniProtKB/Swiss-Prot:O32178" /translation="MHKHIRKAAVLGSGVMGSGIAAHLANIGIPVLLLDIVPNDLTKE EEKKGLTKDSSEVRSRLSRQAMKKLLKQKPAPLTSAKNTSYITPGNLEDDAEKLKEAD WIIEVVVENLEVKKKIFALVDEHRKTGSIVSSNTSGISVQEMAEGRSDDFKAHFLGTH FFNPARYLKLLEIIPIKETDPDILKFMTAFGENVLGKGVVTAKDTPNFIANRIGTYGL LVTVQEMLKGGYQVGEVDSITGPLIGRPKSATFRTLDVVGLDTFAHVARNVYDKADGD EKEVFRIPSFMNDMLEKGWIGSKAGQGFYKKEGKTIYELDPVTLTYGERTKMKSPALE AAKQAKGTKAKMKALIYSDDRAGRLLWNITSQTLLYSAELLGEIADDIHAIDQAMKWG FGWELGPFEMWDAIGLKQSAEKLEQLGADMPGWIKEMLDKGNETFYIKENGTVFYYDR GEYRAVKENKKRIHLQALKETKGVIAKNSGASLIDLGDDVALLEFHSKSNAIGLDIIQ MIHKGLEETERNYKGLVIGNQGKNFCVGANLAMILMEVQDDNFLEVDFVIRRFQETMM KIKYSAKPVVAAPFGMTLGGGTEACLPAARIQAASEAYMGLVESGVGLIPGGGGNKEL YINHLRRGHDPMNAAMKTFETIAMAKVSASAQEAREMNILKETDQISVNQDHLLYDAK QLAASLYDTGWRPPVKEKVKVPGETGYAALLLGAEQMKLSGYISEHDFKIAKKLAYVI AGGKVPFGTEVDEEYLLEIEREAFLSLSGEAKSQARMQHMLVKGKPLRN*" /label="fadN CDS" gene complement(2994348..2996717) /gene="fadN" /locus_tag="BSU_32840" /old_locus_tag="BSU32840" /label="fadN gene" promotor_-35 2996136..2996141 /Source="Nicolas_upshift_promotors" /id="U2573" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1035 /SigmaFactorBS="tcggtgtgtcctttgctgtaacaacgcctttcccgagGACAT TttctccgaaagctgTCATAAACTTTAAAATATCaggatccgtttccttaatcggaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2996156..2996174 /Source="Nicolas_upshift_promotors" /id="U2573" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1035 /SigmaFactorBS="tcggtgtgtcctttgctgtaacaacgcctttcccgagGACAT TttctccgaaagctgTCATAAACTTTAAAATATCaggatccgtttccttaatcggaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2996159 /Source="Nicolas_upshifts" /id="U2573" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1035 /SigmaFactorBS="tcggtgtgtcctttgctgtaacaacgcctttcccgagGACAT TttctccgaaagctgTCATAAACTTTAAAATATCaggatccgtttccttaatcggaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2996785..2996804) /Source="Nicolas_upshift_promotors" /id="U2574" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.622377622377622" /psig=1 /xcortree=375 /SigmaFactorBS="catacaaaaaaataacaaattagCTATTGAAgtcgaaccgga aaTCTTTTAAGATGAAAGAAGAaacgggtttcattttttttagtcaaaaaatgaatga c" /listShort="fadN, fadA, fadE, yusI" /listLong="yusH, yusG, yusF, yusE, S1263, yusD" /label="promotor_-10" upshifts complement(2996788) /Source="Nicolas_upshifts" /id="U2574" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.622377622377622" /psig=1 /xcortree=375 /SigmaFactorBS="catacaaaaaaataacaaattagCTATTGAAgtcgaaccgga aaTCTTTTAAGATGAAAGAAGAaacgggtttcattttttttagtcaaaaaatgaatga c" /listShort="fadN, fadA, fadE, yusI" /listLong="yusH, yusG, yusF, yusE, S1263, yusD" /label="upshifts" S_feature complement(2996796..2997062) /Source="Nicolas_S_feature" /locus_tag="new_3372473_3372739_c" /HighExp="S8, S6, S7, BT, B36, G/S, B60, S5, Pyr, S3" /AntisenseName="yuzL" /AntisenseCor="0.77564732124057401" /AntisenseRegPval="-54.6" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S1264" promotor_-35 complement(2996818..2996825) /Source="Nicolas_upshift_promotors" /id="U2574" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.622377622377622" /psig=1 /xcortree=375 /SigmaFactorBS="catacaaaaaaataacaaattagCTATTGAAgtcgaaccgga aaTCTTTTAAGATGAAAGAAGAaacgggtttcattttttttagtcaaaaaatgaatga c" /listShort="fadN, fadA, fadE, yusI" /listLong="yusH, yusG, yusF, yusE, S1263, yusD" /label="promotor_-35" promotor_-35 2996843..2996849 /Source="Nicolas_upshift_promotors" /id="U2575" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=890 /SigmaFactorBS="ctaatttgttattttttTGTATGAagcctataaaagtcGGGC AACTTAAGcccggaggtgaagggaatggtacgagagaaaaaaaatccgtcttcagcgg c" /listShort="yuzL, S1265, yuzM, yusN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2996864..2996875 /Source="Nicolas_upshift_promotors" /id="U2575" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=890 /SigmaFactorBS="ctaatttgttattttttTGTATGAagcctataaaagtcGGGC AACTTAAGcccggaggtgaagggaatggtacgagagaaaaaaaatccgtcttcagcgg c" /listShort="yuzL, S1265, yuzM, yusN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2996886 /Source="Nicolas_upshifts" /id="U2575" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=890 /SigmaFactorBS="ctaatttgttattttttTGTATGAagcctataaaagtcGGGC AACTTAAGcccggaggtgaagggaatggtacgagagaaaaaaaatccgtcttcagcgg c" /listShort="yuzL, S1265, yuzM, yusN" /GFF_Attribute="listLong" /label="upshifts" CDS 2996892..2997038 /gene="yuzL" /locus_tag="BSU_32849" /old_locus_tag="BSU32849" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 17189250" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097783.1" /db_xref="EnsemblGenomes-Gn:BSU32849" /db_xref="EnsemblGenomes-Tr:CAX52689" /db_xref="InterPro:IPR025625" /db_xref="UniProtKB/Swiss-Prot:C0H3R0" /translation="MVREKKNPSSAAVSAASVKGDAGPTQHYGGGKRTSQNQQYKKHN MGQS*" /label="yuzL CDS" gene 2996892..2997038 /gene="yuzL" /locus_tag="BSU_32849" /old_locus_tag="BSU32849" /label="yuzL gene" S_feature 2997039..2998065 /Source="Nicolas_S_feature" /locus_tag="new_3372716_3373742" /HighExp="S8, S5, S7, S4, S6, nit, ferm, T5.0H, S3, LoTm" /AntisenseName="fadM" /AntisenseCor="0.80952501049450498" /AntisenseRegPval="-63" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1265" CDS complement(2997063..2997971) /gene="putM" /locus_tag="BSU_32850" /old_locus_tag="BSU32850" /EC_number="1.5.5.2" /function="3.2: Degradation" /experiment="publication(s) with functional evidences, PMID:17189250, 17536821, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 17536821, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="proline dehydrogenase 1" /protein_id="NP_391164.1" /db_xref="EnsemblGenomes-Gn:BSU32850" /db_xref="EnsemblGenomes-Tr:CAB15274" /db_xref="GOA:O32179" /db_xref="InterPro:IPR002872" /db_xref="InterPro:IPR008219" /db_xref="InterPro:IPR015659" /db_xref="InterPro:IPR029041" /db_xref="SubtiList:BG14025" /db_xref="UniProtKB/Swiss-Prot:O32179" /translation="MLRHVFLFLSQNKTLTKFAKAYGTRLGARRFVAGDTIESAVKTV KRLNRSGLCATIDYLGEYAASEKEANQVAEECKKAIQAIAEHQLNSELSLKLTSIGLD LSEELALTHLRAILSVAKQYDVAVTIDMEDYSHYEQTLSIYRQCKQEFEKLGTVIQAY LYRAAEDIRKMRDLKPNLRLVKGAYKESAAVAFPDKRGTDLHFQSLIKLQLLSGNYTA VATHDDDIIAFTKQLVAEHQIPASQFEFQMLYGIRPERQKELAKEGYRMRVYVPYGTD WFSYFMRRIAERPANAAFVLKGILKK*" /label="putM CDS" gene complement(2997063..2997971) /gene="putM" /locus_tag="BSU_32850" /old_locus_tag="BSU32850" /label="putM gene" S_feature complement(2997972..2998494) /Source="Nicolas_S_feature" /locus_tag="new_3373649_3374171_c" /HighExp="S8, S6, S7, BT, B36, B60, G/S, Pyr, S5, SMMPr" /AntisenseName="yuzM" /AntisenseCor="0.77827902986544495" /AntisenseRegPval="-55.2" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S1266" CDS 2998066..2998311 /gene="yuzM" /locus_tag="BSU_32859" /old_locus_tag="BSU32859" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097784.1" /db_xref="EnsemblGenomes-Gn:BSU32859" /db_xref="EnsemblGenomes-Tr:CAX52690" /db_xref="InterPro:IPR012347" /db_xref="UniProtKB/Swiss-Prot:C0H3R1" /translation="MDNQQQSQMPPSVISTKDHLYLNDMLNWNLLAMKKAHFMAQQCQ DQTLKQELDRVGHMHHDHYQRILKHLQPGQQQSGYIQ*" /label="yuzM CDS" gene 2998066..2998311 /gene="yuzM" /locus_tag="BSU_32859" /old_locus_tag="BSU32859" /label="yuzM gene" CDS 2998324..2998656 /gene="yusN" /locus_tag="BSU_32860" /old_locus_tag="BSU32860" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative spore coat-like protein" /protein_id="NP_391165.1" /db_xref="EnsemblGenomes-Gn:BSU32860" /db_xref="EnsemblGenomes-Tr:CAB15275" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR012851" /db_xref="SubtiList:BG14026" /db_xref="UniProtKB/Swiss-Prot:O32180" /translation="MNQQNQKISNPQTPVPTTSEMNDRDFVNELLTTEKYMTTAYCTA LHEFSHESLYQDIQSIFDESQKAQRKLYDLMFQYGWYSVEAEDSQKLQQSYQKFQQTI QQQSPYQQ*" /label="yusN CDS" gene 2998324..2998656 /gene="yusN" /locus_tag="BSU_32860" /old_locus_tag="BSU32860" /label="yusN gene" promotor_-10 complement(2998477..2998496) /Source="Nicolas_upshift_promotors" /id="U2576" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1348 /SigmaFactorBS="ttggaacatgagatcatatagttttctttgcgcttTTTGTGA CTCatcaaaaatggatTGAATATCCTGATAAAGAGActcgtggctgaattcgtgcaag g" /listShort="S1266, fadM, S1264, fadN, fadA, fadE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2998494) /Source="Nicolas_upshifts" /id="U2576" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1348 /SigmaFactorBS="ttggaacatgagatcatatagttttctttgcgcttTTTGTGA CTCatcaaaaatggatTGAATATCCTGATAAAGAGActcgtggctgaattcgtgcaag g" /listShort="S1266, fadM, S1264, fadN, fadA, fadE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2998510..2998519) /Source="Nicolas_upshift_promotors" /id="U2576" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1348 /SigmaFactorBS="ttggaacatgagatcatatagttttctttgcgcttTTTGTGA CTCatcaaaaatggatTGAATATCCTGATAAAGAGActcgtggctgaattcgtgcaag g" /listShort="S1266, fadM, S1264, fadN, fadA, fadE" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2998645 /Source="Nicolas_upshifts" /id="D1699" /incds=0 /nref=24 /ntot=46 /MaxReadThrough="2.684" /MaxDrop="5.38418" /score="9.88876972" /energy="-10.2" /TU="NA" /idTUdmin="U2575" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2998717..2998724 /Source="Nicolas_upshift_promotors" /id="U2577" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.648351648351648" /psig="0.999000999001" /xcortree=2125 /SigmaFactorBS="gggcatctatcctttttttgtgtaaaatCAGTTGACttttca tttacgcTTATTTATATTTAATAAGCAttaactattttgtcattaaaatatatataca g" /listShort="yusO, yusP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2998738..2998757 /Source="Nicolas_upshift_promotors" /id="U2577" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.648351648351648" /psig="0.999000999001" /xcortree=2125 /SigmaFactorBS="gggcatctatcctttttttgtgtaaaatCAGTTGACttttca tttacgcTTATTTATATTTAATAAGCAttaactattttgtcattaaaatatatataca g" /listShort="yusO, yusP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2998749 /Source="Nicolas_upshifts" /id="U2577" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.648351648351648" /psig="0.999000999001" /xcortree=2125 /SigmaFactorBS="gggcatctatcctttttttgtgtaaaatCAGTTGACttttca tttacgcTTATTTATATTTAATAAGCAttaactattttgtcattaaaatatatataca g" /listShort="yusO, yusP" /GFF_Attribute="listLong" /label="upshifts" CDS 2998815..2999282 /gene="mdtR" /locus_tag="BSU_32870" /old_locus_tag="BSU32870" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12923086, 19286808" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12923086, 19286808; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (MarR family, low level antibiotic resistance)" /protein_id="NP_391166.1" /db_xref="EnsemblGenomes-Gn:BSU32870" /db_xref="EnsemblGenomes-Tr:CAB15276" /db_xref="GOA:O32181" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:1S3J" /db_xref="SubtiList:BG14027" /db_xref="UniProtKB/Swiss-Prot:O32181" /translation="MKSADQLMSDIQLSLQALFQKIQPEMLESMEKQGVTPAQLFVLA SLKKHGSLKVSEIAERMEVKPSAVTLMADRLEQKNLIARTHNTKDRRVIDLSLTDEGD IKFEEVLAGRKAIMARYLSFLTEEEMLQAAHITAKLAQAAETDEKQNMKRGNG*" /label="mdtR CDS" gene 2998815..2999282 /gene="mdtR" /locus_tag="BSU_32870" /old_locus_tag="BSU32870" /label="mdtR gene" CDS 2999279..3000904 /gene="mdtP" /locus_tag="BSU_32880" /old_locus_tag="BSU32880" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 19286808" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 19286808; Product type t: transporter" /codon_start=1 /transl_table=11 /product="multidrug-efflux transporter" /protein_id="NP_391167.1" /db_xref="EnsemblGenomes-Gn:BSU32880" /db_xref="EnsemblGenomes-Tr:CAB15277" /db_xref="GOA:O32182" /db_xref="InterPro:IPR004638" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG14028" /db_xref="UniProtKB/Swiss-Prot:O32182" /translation="MKMSKEGKQSKRTLLITGLIIAMFFSALDGTIVGTAMPKIVGDL GGLSMMTWLTTAYLLTSTTIVPIAGKLADLLGRRIVYVSGLIIFMAASALCGMANNMT ELIIFRGLQGIGGGIMMPMAMIVIGDLFTGKQRAKFQGVFGAIYGLASVIGPQIGGWI VDSLNWKWVFYINLPVGIIAVIFIARGLQGRQQTGPINFDIAGIFTMIVGVVSLLLAL SFGGKDYAWDSWQILGLFALALIGIVSFIIVESKAKEPILPMYLFKNRTFTFLNLIGF FMSIGMFGAITFVPFFMQGIVGVSASESGTIMTPMMISMIITSIIGGQLVYKIGIKPQ IITGMLVMAGGFLLLTTLDLDTSKLVATSFMAIIGLGMGLVMPILTLALQESFSKEEL GVVTSSSQFFRSIGGTFGITMLGAVMNARSGNLLTDKLVPYLDSLPAQASSFAAQLKG MIDTNPQGLLQSLFSPDAVKQIPAAFSSHIVPILKTSLMDSLHSVFYTGLIFIAVGAV FTLFLKPIKLSNKKAEDQQEKEKAAKAVESPSH*" /label="mdtP CDS" gene 2999279..3000904 /gene="mdtP" /locus_tag="BSU_32880" /old_locus_tag="BSU32880" /label="mdtP gene" downshifts 3000889 /Source="Nicolas_upshifts" /id="D1700" /incds=0 /nref=217 /ntot=257 /MaxReadThrough="0.3188" /MaxDrop="5.64223" /score="42.0555168" /energy="-17.7" /TU="NA" /idTUdmin="U2577" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3000940..3001323) /gene="yusQ" /locus_tag="BSU_32890" /old_locus_tag="BSU32890" /EC_number="5.3.2.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 25219626; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="hydratase of unidentified specificity (tautomerase superfamily)" /protein_id="NP_391168.1" /db_xref="EnsemblGenomes-Gn:BSU32890" /db_xref="EnsemblGenomes-Tr:CAB15278" /db_xref="GOA:O32183" /db_xref="InterPro:IPR004370" /db_xref="InterPro:IPR014347" /db_xref="SubtiList:BG14029" /db_xref="UniProtKB/Swiss-Prot:O32183" /translation="MPFVQIHLRSGRSEVWLQKLSRTIHQSMIEEINVPEDDYFQVIR QYEKSEFFYDPFYLQVERTDELIYIHFTLKQSRTTEQKKALYRSIASRIHSELGVRKE DVFIMLAGNQDEDWSFGNGRAQMIE*" /label="yusQ CDS" gene complement(3000940..3001323) /gene="yusQ" /locus_tag="BSU_32890" /old_locus_tag="BSU32890" /label="yusQ gene" CDS complement(3001342..3001731) /gene="yusR" /locus_tag="BSU_32900" /old_locus_tag="BSU32900" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15294834; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 3-oxoacyl-acyl-carrier protein reductase" /protein_id="NP_391169.1" /db_xref="EnsemblGenomes-Gn:BSU32900" /db_xref="EnsemblGenomes-Tr:CAB15279" /db_xref="GOA:O32184" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG14030" /db_xref="UniProtKB/Swiss-Prot:O32184" /translation="MKGMFFCARAVVPFMKKSKDGAIVNVGSIAGITGAGSSMPYAVS KSAVHGLTKSLAHALAPEIRVSGVAPGAVATRWWAGREEKMKSMIGSLLLQCIAEPDD VAKLICSLIEQESLTGQIITIDSGQTL*" /label="yusR CDS" gene complement(3001342..3001731) /gene="yusR" /locus_tag="BSU_32900" /old_locus_tag="BSU32900" /label="yusR gene" CDS complement(3001753..3002082) /gene="yusS" /locus_tag="BSU_32910" /old_locus_tag="BSU32910" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="conserved enzyme of unknown function" /protein_id="NP_391170.1" /db_xref="EnsemblGenomes-Gn:BSU32910" /db_xref="EnsemblGenomes-Tr:CAB15280" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG14031" /db_xref="UniProtKB/Swiss-Prot:O32185" /translation="MNVLNKIALVTGGGTGIGKAASMELAKRGAIVAVNYSRSQSEAE ETVEMIQKAGGQAFAIQADVSKNSDVQDMIQAIVNTHGTVDILVNNASITRHIPMDDL EAATEDV*" /label="yusS CDS" gene complement(3001753..3002082) /gene="yusS" /locus_tag="BSU_32910" /old_locus_tag="BSU32910" /label="yusS gene" promotor_-10 complement(3002117..3002136) /Source="Nicolas_upshift_promotors" /id="U2578" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.972027972027972" /psig=1 /xcortree=1537 /SigmaFactorBS="atcaatctgagtgatatctagtatctttaacaatCATTATAC gtaacatcaaagcTGGATTACAATGGAATCAGAaatatactttagtcaacagcaagga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 3002124..3002131 /Source="Nicolas_upshift_promotors" /id="U2579" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.707292707292707" /psig="0.998001998001998" /xcortree=1789 /SigmaFactorBS="tgctgttgactaaagtatatttctgattCCATTGTAatccag ctttgatgTTACGTATAATGATTGTTAAagatactagatatcactcagattgatagta a" /listShort="yusT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3002131) /Source="Nicolas_upshifts" /id="U2578" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.972027972027972" /psig=1 /xcortree=1537 /SigmaFactorBS="atcaatctgagtgatatctagtatctttaacaatCATTATAC gtaacatcaaagcTGGATTACAATGGAATCAGAaatatactttagtcaacagcaagga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3002146..3002165 /Source="Nicolas_upshift_promotors" /id="U2579" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.707292707292707" /psig="0.998001998001998" /xcortree=1789 /SigmaFactorBS="tgctgttgactaaagtatatttctgattCCATTGTAatccag ctttgatgTTACGTATAATGATTGTTAAagatactagatatcactcagattgatagta a" /listShort="yusT" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3002150..3002157) /Source="Nicolas_upshift_promotors" /id="U2578" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.972027972027972" /psig=1 /xcortree=1537 /SigmaFactorBS="atcaatctgagtgatatctagtatctttaacaatCATTATAC gtaacatcaaagcTGGATTACAATGGAATCAGAaatatactttagtcaacagcaagga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3002156 /Source="Nicolas_upshifts" /id="U2579" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.707292707292707" /psig="0.998001998001998" /xcortree=1789 /SigmaFactorBS="tgctgttgactaaagtatatttctgattCCATTGTAatccag ctttgatgTTACGTATAATGATTGTTAAagatactagatatcactcagattgatagta a" /listShort="yusT" /GFF_Attribute="listLong" /label="upshifts" CDS 3002216..3003103 /gene="yusT" /locus_tag="BSU_32920" /old_locus_tag="BSU32920" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12169591, 17526699, 27965289" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12169591, 17526699, 27965289; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of unknown specificity(LysR family)" /protein_id="NP_391171.1" /db_xref="EnsemblGenomes-Gn:BSU32920" /db_xref="EnsemblGenomes-Tr:CAB15281" /db_xref="GOA:O32186" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG14032" /db_xref="UniProtKB/Swiss-Prot:O32186" /translation="MESGDLRVFQMVAREGTITKAALQLGYVQSNVTARIQQLEAELG TTLFLRHNRGMTLSASGKLLLDYANKIIGLLDEASKALSSSAEPSGPLMIGCTQTTAA VRLPKLLASYYEEHPNVQLSLTTGHTQFLLDKVLRYELDGAFIGCECHHPELESYPAF EEEPVVVSAASVPDVEEAITKPILVYSTGCSYRETLEKWLRSVGVTQPVIMEFGTLEA IIGGVTAGLGISLLPRTVVQKHEAEGSIRLYPLPEALSQMKTEFIVRKDSFISSALRT FMDSFTPVKTAESQKSSLL*" /label="yusT CDS" gene 3002216..3003103 /gene="yusT" /locus_tag="BSU_32920" /old_locus_tag="BSU32920" /label="yusT gene" CDS complement(3003123..3003410) /gene="yusU" /locus_tag="BSU_32930" /old_locus_tag="BSU32930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22078549" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391172.1" /db_xref="EnsemblGenomes-Gn:BSU32930" /db_xref="EnsemblGenomes-Tr:CAB15282" /db_xref="InterPro:IPR020393" /db_xref="SubtiList:BG14033" /db_xref="UniProtKB/Swiss-Prot:O32187" /translation="MRKLLAVFSKGRWKMEQKLQEQLDGLLEKYTELLLGETNDELKE EVKQWILYTHIAKSMPPLAKHWNATYPDAKQGIKEIIQHIKELNEAHRNKQ*" /label="yusU CDS" gene complement(3003123..3003410) /gene="yusU" /locus_tag="BSU_32930" /old_locus_tag="BSU32930" /label="yusU gene" downshifts complement(3003135) /Source="Nicolas_upshifts" /id="D1701" /incds=0 /nref=113 /ntot=280 /MaxReadThrough="1.05563" /MaxDrop="5.97768" /score="17.1690128" /energy="-13.2" /TU="NA" /idTUdmin="U2580" /TUdmin="-14" /isTUend="TRUE" /label="downshifts" CDS complement(3003435..3004262) /gene="feuV" /locus_tag="BSU_32940" /old_locus_tag="BSU32940" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 16672620, 24847778, 25288929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 16672620, 24847778, 25288929; Product type t: transporter" /codon_start=1 /transl_table=11 /product="iron(III)-siderophore transporter (ATP binding component)" /protein_id="NP_391173.1" /db_xref="EnsemblGenomes-Gn:BSU32940" /db_xref="EnsemblGenomes-Tr:CAB15283" /db_xref="GOA:O32188" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG14034" /db_xref="UniProtKB/Swiss-Prot:O32188" /translation="MGMSAISTETLSLGYGDAVIIDELNLTIPKGEITVFIGSNGCGK STLLRSLARLMKPRGGSVLLEGRAIAKLPTKEVAKELAILPQGPSAPEGLTVHQLVKQ GRYPYQNWLKQWSKEDEEAVERALKATKLEDMADRAVDSLSGGQRQRAWIAMTLAQET DIILLDEPTTYLDMTHQIEILDLLFELNEKEDRTIVMVLHDLNLACRYAHHLVAIKDK RIYAEGRPEEVITCDLVQNVFSMNCQVTQDPLFGTPLCIPHGRGRCIVQEAAFTSHG* " /label="feuV CDS" gene complement(3003435..3004262) /gene="feuV" /locus_tag="BSU_32940" /old_locus_tag="BSU32940" /label="feuV gene" downshifts complement(3003451) /Source="Nicolas_upshifts" /id="D1702" /incds=0 /nref=2 /ntot=77 /MaxReadThrough="5.36684" /MaxDrop="3.19022" /score="11.3999731" /energy="-19.8" /TU="U2580" /idTUdmin="U2581" /TUdmin=220 /isTUend="FALSE" /label="downshifts" S_feature complement(3004263..3004400) /Source="Nicolas_S_feature" /locus_tag="new_3379940_3380077_c" /HighExp="T-5.40H, Paraq, H2O2, GM-0.2, HiOs, GM 5, dia15, GM 25, T-3.40H, GM 45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S1267" promotor_-10 complement(3004385..3004404) /Source="Nicolas_upshift_promotors" /id="U2580" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.463536463536464" /psig=1 /xcortree=2101 /SigmaFactorBS="taaacgtcaattatgtccataaaactaattgaaaatgATTTt caaagtcagtgtttTCTGCTACAATGAGGGATATatgaccatatcaaatggctgaata t" /listShort="S1267, yusV, yusU" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3004400) /Source="Nicolas_upshifts" /id="U2580" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.463536463536464" /psig=1 /xcortree=2101 /SigmaFactorBS="taaacgtcaattatgtccataaaactaattgaaaatgATTTt caaagtcagtgtttTCTGCTACAATGAGGGATATatgaccatatcaaatggctgaata t" /listShort="S1267, yusV, yusU" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3004420..3004423) /Source="Nicolas_upshift_promotors" /id="U2580" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.463536463536464" /psig=1 /xcortree=2101 /SigmaFactorBS="taaacgtcaattatgtccataaaactaattgaaaatgATTTt caaagtcagtgtttTCTGCTACAATGAGGGATATatgaccatatcaaatggctgaata t" /listShort="S1267, yusV, yusU" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3004480..3004917) /gene="cotNW" /locus_tag="BSU_32950" /old_locus_tag="BSU32950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 26497467; Product type m : membrane component" /codon_start=1 /transl_table=11 /product="spore lipoprotein" /protein_id="NP_391174.1" /db_xref="EnsemblGenomes-Gn:BSU32950" /db_xref="EnsemblGenomes-Tr:CAB15284" /db_xref="InterPro:IPR025623" /db_xref="SubtiList:BG14035" /db_xref="UniProtKB/Swiss-Prot:O32189" /translation="MHLIRAAGAVCLAVVLIAGCRFNEDQHQAEGENTAVTQLKSVPY SNFSLRVSYGDGEHNRYEGIYTKNGTQEKAEIQDKLSGVNQEGEEALDEMKMILSELS VTDQMAETEVIHSVLAAFNLDSHYDHIDLKLKLKDGSIREIKK*" /label="cotNW CDS" gene complement(3004480..3004917) /gene="cotNW" /locus_tag="BSU_32950" /old_locus_tag="BSU32950" /label="cotNW gene" promotor_-10 complement(3004941..3004959) /Source="Nicolas_upshift_promotors" /id="U2581" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1192 /SigmaFactorBS="aatgccccggctttttcaattcttctcTGAATGaggatttca ttctctGGATATACCTAAAATAAATggaatcctacaggggggaaacatatgcatttga t" /listShort="yusW, S1267, yusV" /listLong="yusU" /label="promotor_-10" upshifts complement(3004947) /Source="Nicolas_upshifts" /id="U2581" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1192 /SigmaFactorBS="aatgccccggctttttcaattcttctcTGAATGaggatttca ttctctGGATATACCTAAAATAAATggaatcctacaggggggaaacatatgcatttga t" /listShort="yusW, S1267, yusV" /listLong="yusU" /label="upshifts" promotor_-35 complement(3004975..3004980) /Source="Nicolas_upshift_promotors" /id="U2581" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1192 /SigmaFactorBS="aatgccccggctttttcaattcttctcTGAATGaggatttca ttctctGGATATACCTAAAATAAATggaatcctacaggggggaaacatatgcatttga t" /listShort="yusW, S1267, yusV" /listLong="yusU" /label="promotor_-35" CDS complement(3005027..3006535) /gene="yusYc" /locus_tag="BSU_32960" /old_locus_tag="BSU32960" /EC_number="3.4.24.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 11741842; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="oligoendopeptidase; C-terminal part of YusY" /db_xref="SubtiList:BG14037" /translation="GLMNRLSADFQSSLVTLDHKLVDINQDVWNELLTKPGLRDVSYI LNERRQRVAEKLSPGKEKLIGNLAVDGYHAWSDLYNMVVGKMTIPYEENGENKQLSVG QAENMMDHQDRTVRKTVYERFRQAWESKQDIFSSTLNHLAGFRLETYKARGWENVLKE PLQINRMKKETLDTMWQVITENKKPFVQFLNRKASMLGLEKLSWYDVEAPIGSDGKVY SYDEAANIITSQFSTFGKKLSSFTEKAFRDGWIEAEDRSGKRVGGFCTSFPDSGESRI FMTFSGSASNVSTLAHELGHAFHQEAMLNVRPLNRSYAMNVAETASTFAEMIVADATV QQAETREEKLVLLEDKVQRSVAFFMNIHARFLFETRFYEERKRGVVPASRLNELMEEA QREAYCNALEEYHPLFWASKLHFHITRVPFYNFPYTFGYLFSLGIYALALEEKDTFEE KYMALLRDTASMTVEDLAMKHLGADITKRDFWENAIKLAVRDAETFLQMTES*" /label="yusYc CDS" gene complement(3005027..3006535) /gene="yusYc" /locus_tag="BSU_32960" /old_locus_tag="BSU32960" /pseudo /label="yusYc gene" downshifts complement(3005048) /Source="Nicolas_upshifts" /id="D1703" /incds=0 /nref=125 /ntot=240 /MaxReadThrough="2.57385" /MaxDrop="6.5698" /score="6.83314975" /energy="-12" /TU="NA" /idTUdmin="U2582" /TUdmin="-13" /isTUend="TRUE" /label="downshifts" CDS complement(3006526..3006822) /gene="yusYn" /locus_tag="BSU_32970" /old_locus_tag="BSU32970" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 11741842; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="oligoendopeptidase; N-terminal part of YusY" /translation="MALQGVGQRWDLDSFFKGGSQSEEFKGYIEKLSQSLRAFQDRTD AFQVPESPEEAEGLTALLDLFEQTSVKLQQAGAFVACLQAQNINDQKAIEHQAS*" /label="yusYn CDS" gene complement(3006526..3006822) /gene="yusYn" /locus_tag="BSU_32970" /old_locus_tag="BSU32970" /pseudo /label="yusYn gene" promotor_-10 complement(3006845..3006864) /Source="Nicolas_upshift_promotors" /id="U2582" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.708291708291708" /psig=1 /xcortree=2899 /SigmaFactorBS="actatcctgaacacgaaatgacgcctgtaatagaaatttTTA TacaataattcagaaTTGTTCTATAATAGAACGAAagaaggaaaggggttttgtgata t" /listShort="yusY, yusY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3006861) /Source="Nicolas_upshifts" /id="U2582" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.708291708291708" /psig=1 /xcortree=2899 /SigmaFactorBS="actatcctgaacacgaaatgacgcctgtaatagaaatttTTA TacaataattcagaaTTGTTCTATAATAGAACGAAagaaggaaaggggttttgtgata t" /listShort="yusY, yusY" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3006879..3006882) /Source="Nicolas_upshift_promotors" /id="U2582" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.708291708291708" /psig=1 /xcortree=2899 /SigmaFactorBS="actatcctgaacacgaaatgacgcctgtaatagaaatttTTA TacaataattcagaaTTGTTCTATAATAGAACGAAagaaggaaaggggttttgtgata t" /listShort="yusY, yusY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3006899..3006904 /Source="Nicolas_upshift_promotors" /id="U2583" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.975024975024975" /psig="0.998001998001998" /xcortree=2942 /SigmaFactorBS="atagaacaattctgaattattgtataaaaatttctattacag gCGTCATttcgtgttcagGATAGTACAATAGCTGTAGCagtttaataggagggttagg a" /listShort="yusZ, mrgA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3006916..3006935 /Source="Nicolas_upshift_promotors" /id="U2583" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.975024975024975" /psig="0.998001998001998" /xcortree=2942 /SigmaFactorBS="atagaacaattctgaattattgtataaaaatttctattacag gCGTCATttcgtgttcagGATAGTACAATAGCTGTAGCagtttaataggagggttagg a" /listShort="yusZ, mrgA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3006916 /Source="Nicolas_upshifts" /id="U2583" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.975024975024975" /psig="0.998001998001998" /xcortree=2942 /SigmaFactorBS="atagaacaattctgaattattgtataaaaatttctattacag gCGTCATttcgtgttcagGATAGTACAATAGCTGTAGCagtttaataggagggttagg a" /listShort="yusZ, mrgA" /GFF_Attribute="listLong" /label="upshifts" CDS 3006956..3007798 /gene="yusZ" /locus_tag="BSU_32980" /old_locus_tag="BSU32980" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative short-chain acyl dehydrogenase" /protein_id="NP_391177.1" /db_xref="EnsemblGenomes-Gn:BSU32980" /db_xref="EnsemblGenomes-Tr:CAB15287" /db_xref="GOA:P37959" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10863" /db_xref="UniProtKB/Swiss-Prot:P37959" /translation="MNKKIAIVTGASSGFGLLAAVKLARSFFVIATSRQPEKAEQLRE LAAAHNVSDSIHITALDVTDEQSIVSFGKAVSAYAPIDLLVNNAGTAYGGFIEDVPME HFRQQFETNVFGVIHVTKTVLPYIRKHGGAKIINVSSISGLTGFPALSPYVSSKHALE GFSESLRIELLPFGIETALIEPGSYKTSIWSTSLSNFMSVPADDSAYHQYYKKILSYV QKNGEESGDPQEVADLIYQLATKQHIKNLRYPIGKGIKLTLLFRSLFPWSAWESILKK KLFS*" /label="yusZ CDS" gene 3006956..3007798 /gene="yusZ" /locus_tag="BSU_32980" /old_locus_tag="BSU32980" /label="yusZ gene" promotor_-35 3007328..3007334 /Source="Nicolas_upshift_promotors" /id="U2584" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=826 /SigmaFactorBS="tgtgatccatgtgacaaaaaccgtgctgcctTACATAAgaaa gcatggcggcGCAAAGATTATAaacgtgagcagcatcagcggactgacaggattccca g" /GFF_Attribute="listShort" /listLong="mrgA" /label="promotor_-35" promotor_-10 3007349..3007360 /Source="Nicolas_upshift_promotors" /id="U2584" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=826 /SigmaFactorBS="tgtgatccatgtgacaaaaaccgtgctgcctTACATAAgaaa gcatggcggcGCAAAGATTATAaacgtgagcagcatcagcggactgacaggattccca g" /GFF_Attribute="listShort" /listLong="mrgA" /label="promotor_-10" upshifts 3007357 /Source="Nicolas_upshifts" /id="U2584" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=826 /SigmaFactorBS="tgtgatccatgtgacaaaaaccgtgctgcctTACATAAgaaa gcatggcggcGCAAAGATTATAaacgtgagcagcatcagcggactgacaggattccca g" /GFF_Attribute="listShort" /listLong="mrgA" /label="upshifts" promotor_-35 3007825..3007832 /Source="Nicolas_upshift_promotors" /id="U2585" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.465534465534466" /psig=1 /xcortree=1535 /SigmaFactorBS="aaaaagctattcagctgatctaaattataattattataattt agTATTGATTtttatttagtaTATGATATAATTAAGTCAACagatcacaaggaggacg t" /listShort="mrgA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3007841 /Source="Nicolas_upshifts" /id="U2585" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.465534465534466" /psig=1 /xcortree=1535 /SigmaFactorBS="aaaaagctattcagctgatctaaattataattattataattt agTATTGATTtttatttagtaTATGATATAATTAAGTCAACagatcacaaggaggacg t" /listShort="mrgA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3007844..3007863 /Source="Nicolas_upshift_promotors" /id="U2585" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.465534465534466" /psig=1 /xcortree=1535 /SigmaFactorBS="aaaaagctattcagctgatctaaattataattattataattt agTATTGATTtttatttagtaTATGATATAATTAAGTCAACagatcacaaggaggacg t" /listShort="mrgA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3007888..3008349 /gene="mrgA" /locus_tag="BSU_32990" /old_locus_tag="BSU32990" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12029044, 8709848, 21057011, 22194458, 24123749, 28434086" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12029044, 8709848, 21057011, 22194458, 24123749, 28434086; Product type f : factor" /codon_start=1 /transl_table=11 /product="metalloregulation DNA-binding stress protein" /protein_id="NP_391178.1" /db_xref="EnsemblGenomes-Gn:BSU32990" /db_xref="EnsemblGenomes-Tr:CAB15288" /db_xref="GOA:P37960" /db_xref="InterPro:IPR002177" /db_xref="InterPro:IPR008331" /db_xref="InterPro:IPR009078" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR023188" /db_xref="PDB:2CHP" /db_xref="SubtiList:BG10864" /db_xref="UniProtKB/Swiss-Prot:P37960" /translation="MKTENAKTNQTLVENSLNTQLSNWFLLYSKLHRFHWYVKGPHFF TLHEKFEELYDHAAETVDTIAERLLAIGGQPVATVKEYTEHASITDGGNETSASEMVQ ALVNDYKQISSESKFVIGLAEENQDNATADLFVGLIEEVEKQVWMLSSYLG*" /label="mrgA CDS" gene 3007888..3008349 /gene="mrgA" /locus_tag="BSU_32990" /old_locus_tag="BSU32990" /label="mrgA gene" downshifts 3008325 /Source="Nicolas_upshifts" /id="D1704" /incds=0 /nref=234 /ntot=274 /MaxReadThrough="1.7919" /MaxDrop="8.26581" /score="36.5549876" /energy="-13.3" /TU="NA" /idTUdmin="U2583" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3008393..3009769) /gene="htrB" /locus_tag="BSU_33000" /old_locus_tag="BSU33000" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11133960, 11717295, 16033468, 16911528, 22307758, 23937099, 24362423" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11133960, 11717295, 16033468, 16911528, 22307758, 23937099, 24362423; Product type f: factor" /codon_start=1 /transl_table=11 /product="protease-associated chaperone for the extracytoplasmic folding and quality control of exported proteins" /protein_id="NP_391180.2" /db_xref="EnsemblGenomes-Gn:BSU33000" /db_xref="EnsemblGenomes-Tr:CAB15290" /db_xref="GOA:Q9R9I1" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR001940" /db_xref="InterPro:IPR009003" /db_xref="InterPro:IPR036034" /db_xref="SubtiList:BG14155" /db_xref="UniProtKB/Swiss-Prot:Q9R9I1" /translation="MDYRRDGQNDQHQTEPSHTEQQNTENQKLIGHSEQELLDAPVSY EAGRQETASALEMEKQETAVKKEKKRRAAWLSPILGGIIGGGLMLGIAPYLPSDQNQA TETASANKQVQSDNFTTAPITNASNIADMVEDLEPTIVGISNIQTSQNNTFGTGGGSS SESESGTGSGVIFKKDSDKAYIITNNHVVEGANKLTVTLYNGETETAKLVGSDTITDL AVLEISGKNVKKVASFGDSSQLRTGEKVIAIGNPLGQQFSGTVTQGIISGLNRTIDVD TTQGTVEMNVLQTDAAINPGNSGGPLINASGQVIGINSLKVSESGVESLGFAIPSNDV EPIVDQLLQNGKVDRPFLGVQMIDMSQVPETYQENTLGLFGDQLGKGVYVKEVQANSP AEKAGIKSEDVIVKLNGKDVESSADIRQILYKDLKVGDKTTIQVLRKGKTKTLNATLT KQTESSSS*" /label="htrB CDS" gene complement(3008393..3009769) /gene="htrB" /locus_tag="BSU_33000" /old_locus_tag="BSU33000" /label="htrB gene" downshifts complement(3008401) /Source="Nicolas_upshifts" /id="D1705" /incds=0 /nref=206 /ntot=257 /MaxReadThrough="1.84997" /MaxDrop="6.39104" /score="17.1953741" /energy="-11.2" /TU="U2586" /idTUdmin="U2586" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" S_feature complement(3009770..3009941) /Source="Nicolas_S_feature" /locus_tag="new_3385447_3385618_c" /HighExp="SMMPr, T-0.40H, T-1.10H, M9-tran, T-1.40H, T1.0H, T0.30H, T1.30H, Etha, M/G" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.67259999999999998" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1268" promotor_-10 complement(3009922..3009941) /Source="Nicolas_upshift_promotors" /id="U2586" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=1764 /SigmaFactorBS="acggcaggcaattttcataatttcacatattcttttcatttt TATCCCACaatgtttgttTATGATATGGTTAAGGGAAGaaaggaagagaaaaagagcg a" /listShort="S1268, htrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3009941) /Source="Nicolas_upshifts" /id="U2586" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=1764 /SigmaFactorBS="acggcaggcaattttcataatttcacatattcttttcatttt TATCCCACaatgtttgttTATGATATGGTTAAGGGAAGaaaggaagagaaaaagagcg a" /listShort="S1268, htrB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3009952..3009959) /Source="Nicolas_upshift_promotors" /id="U2586" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=1764 /SigmaFactorBS="acggcaggcaattttcataatttcacatattcttttcatttt TATCCCACaatgtttgttTATGATATGGTTAAGGGAAGaaaggaagagaaaaagagcg a" /listShort="S1268, htrB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3010002..3010021) /Source="Nicolas_upshift_promotors" /id="U2588" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2391 /SigmaFactorBS="cctcatcttcaactagataaatggtgtatgacaaggcTCTTC ACAtcctttcaacgtcaTTATAAACTAGTTTTAACATacggcaggcaattttcataat t" /GFF_Attribute="listShort" /listLong="S1268, htrB" /label="promotor_-10" misc_feature 3010012..3010031 /Source="Nicolas_upshift_promotors" /id="U2587" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.761238761238761" /psig="0.994005994005994" /xcortree=2013 /SigmaFactorBS="gggataaaaatgaaaagaatatgtgaaattatgaaaattgcc tgccgtatgttaaaacTAGTTTATAATGACGTTGAAaggatgtgaagagccttgtcat a" /listShort="cssR, cssS" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3010014 /Source="Nicolas_upshifts" /id="U2587" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.761238761238761" /psig="0.994005994005994" /xcortree=2013 /SigmaFactorBS="gggataaaaatgaaaagaatatgtgaaattatgaaaattgcc tgccgtatgttaaaacTAGTTTATAATGACGTTGAAaggatgtgaagagccttgtcat a" /listShort="cssR, cssS" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3010020) /Source="Nicolas_upshifts" /id="U2588" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2391 /SigmaFactorBS="cctcatcttcaactagataaatggtgtatgacaaggcTCTTC ACAtcctttcaacgtcaTTATAAACTAGTTTTAACATacggcaggcaattttcataat t" /GFF_Attribute="listShort" /listLong="S1268, htrB" /label="upshifts" S_feature complement(3010022..3011085) /Source="Nicolas_S_feature" /locus_tag="new_3385699_3386762_c" /HighExp="T1.0H, T0.30H, T1.30H, C30, T2.0H, G135, G180, T2.30H, ferm, G150" /AntisenseName="cssR" /AntisenseCor="0.115381389160342" /AntisenseRegPval="-1.2" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1269" promotor_-35 complement(3010036..3010043) /Source="Nicolas_upshift_promotors" /id="U2588" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2391 /SigmaFactorBS="cctcatcttcaactagataaatggtgtatgacaaggcTCTTC ACAtcctttcaacgtcaTTATAAACTAGTTTTAACATacggcaggcaattttcataat t" /GFF_Attribute="listShort" /listLong="S1268, htrB" /label="promotor_-35" CDS 3010047..3010724 /gene="cssR" /locus_tag="BSU_33010" /old_locus_tag="BSU33010" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11555295, 11717295, 12270824, 15856219, 16911528, 17586671, 27026185" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11555295, 11717295, 12270824, 15856219, 16911528, 17586671, 27026185; Product type r: regulator" /codon_start=1 /transl_table=11 /product="folding stress-sensitive two-component response regulator" /protein_id="NP_391181.1" /db_xref="EnsemblGenomes-Gn:BSU33010" /db_xref="EnsemblGenomes-Tr:CAB15291" /db_xref="GOA:O32192" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG14131" /db_xref="UniProtKB/Swiss-Prot:O32192" /translation="MSYTIYLVEDEDNLNELLTKYLENEGWNITSFTKGEDARKKMTP SPHLWILDIMLPDTDGYTLIKEIKAKDPDVPVIFISARDADIDRVLGLELGSNDYISK PFLPRELIIRVQKLLQLVYKEAPPVQKNEIAVSSYRVAEDAREVYDENGNIINLTSKE FDLLLLFIHHKGHPYSREDILLKVWGHDYFGTDRVVDDLVRRLRRKMPELKVETIYGF GYRMMSS*" /label="cssR CDS" gene 3010047..3010724 /gene="cssR" /locus_tag="BSU_33010" /old_locus_tag="BSU33010" /label="cssR gene" CDS 3010721..3012076 /gene="cssS" /locus_tag="BSU_33020" /old_locus_tag="BSU33020" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11555295, 11717295, 12270824, 15856219, 16911528, 17586671, 27026185" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11555295, 11717295, 12270824, 15856219, 16911528, 17586671, 27026185; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="folding stress-sensitive two-component sensor histidine kinase" /protein_id="NP_391182.2" /db_xref="EnsemblGenomes-Gn:BSU33020" /db_xref="EnsemblGenomes-Tr:CAB15292" /db_xref="GOA:O32193" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG14132" /db_xref="UniProtKB/Swiss-Prot:O32193" /translation="MKNKPLAFQIWVVISGILLAISILLLVLFSNTLRDFFTNETYTT IENEQHVLTEYRLPGSIERRYYSEEATAPTTVRSVQHVLLPENEEASSDKDLSILSSS FIHKVYKLADKQEAKKKRYSADVNGEKVFFVIKKGLSVNGQSAMMLSYALDSYRDDLA YTLFKQLLFIIAVVILLSWIPAIWLAKYLSRPLVSFEKHVKRISEQDWDDPVKVDRKD EIGKLGHTIEEMRQKLVQKDETERTLLQNISHDLKTPVMVIRGYTQSIKDGIFPKGDL ENTVDVIECEALKLEKKIKDLLYLTKLDYLAKQKVQHDMFSIVEVTEEVIERLKWARK ELSWEIDVEEDILMPGDPEQWNKLLENILENQIRYAETKIEISMKQDDRNIVITIKND GPHIEDEMLSSLYEPFNKGKKGEFGIGLSIVKRILTLHKASISIENDKTGVTYRIAVP K*" /label="cssS CDS" gene 3010721..3012076 /gene="cssS" /locus_tag="BSU_33020" /old_locus_tag="BSU33020" /label="cssS gene" S_feature complement(3011175..3012103) /Source="Nicolas_S_feature" /locus_tag="new_3386852_3387780_c" /HighExp="T1.0H, T0.30H, T1.30H, T2.0H, T2.30H, ferm, C30, LPhT, T-1.10H, Lbstat" /AntisenseName="cssS" /AntisenseCor="0.27217686232372901" /AntisenseRegPval="-5.2" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigD, SigH, SigA" /TUshortPSig="1, 0.869, 1, 0.999, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1270" downshifts 3012044 /Source="Nicolas_upshifts" /id="D1706" /incds=0 /nref=61 /ntot=203 /MaxReadThrough="0.95076" /MaxDrop="4.47937" /score="13.0972324" /energy="-9.7" /TU="NA" /idTUdmin="U2587" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(3012104..3012268) /gene="spxO" /locus_tag="BSU_33029" /old_locus_tag="BSU33029" /experiment="publication(s) with functional evidences, PMID:21378193" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21378193; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of SpxA degradation" /protein_id="YP_003097785.1" /db_xref="EnsemblGenomes-Gn:BSU33029" /db_xref="EnsemblGenomes-Tr:CAX52691" /db_xref="GOA:O32302" /db_xref="UniProtKB/Swiss-Prot:O32302" /translation="MRELDEMISRLRNRGIKVEKVKYPKQTLSEKKWVHQCKQPLKTN YRDFNGYSFT*" /label="spxO CDS" gene complement(3012104..3012268) /gene="spxO" /locus_tag="BSU_33029" /old_locus_tag="BSU33029" /label="spxO gene" promotor_-35 3012292..3012299 /Source="Nicolas_upshift_promotors" /id="U2589" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=1903 /SigmaFactorBS="tctcattctagattcaccctttcgcttgaGCTTTGACcattc ggtcatctCAATTTATAATATAAATAATacatgataaaaaaacaagttacaataaggt t" /listShort="S1271, yuxN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3012313..3012332 /Source="Nicolas_upshift_promotors" /id="U2589" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=1903 /SigmaFactorBS="tctcattctagattcaccctttcgcttgaGCTTTGACcattc ggtcatctCAATTTATAATATAAATAATacatgataaaaaaacaagttacaataaggt t" /listShort="S1271, yuxN" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(3012317..3012336) /Source="Nicolas_upshift_promotors" /id="U2590" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.477522477522478" /psig=1 /xcortree=3229 /SigmaFactorBS="tatagtcacaccgtctgttataaaattaaccttATTGTAACt tgtttttttatcATGTATTATTTATATTATAAattgagatgaccgaatggtcaaagct c" /listShort="yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3012323..3012435 /Source="Nicolas_S_feature" /locus_tag="new_3388000_3388112" /HighExp="dia5, Diami, T0.30H, T-0.40H, T0.0H, dia15, Salt, ferm, G135, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1271" upshifts 3012323 /Source="Nicolas_upshifts" /id="U2589" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=1903 /SigmaFactorBS="tctcattctagattcaccctttcgcttgaGCTTTGACcattc ggtcatctCAATTTATAATATAAATAATacatgataaaaaaacaagttacaataaggt t" /listShort="S1271, yuxN" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3012330) /Source="Nicolas_upshifts" /id="U2590" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.477522477522478" /psig=1 /xcortree=3229 /SigmaFactorBS="tatagtcacaccgtctgttataaaattaaccttATTGTAACt tgtttttttatcATGTATTATTTATATTATAAattgagatgaccgaatggtcaaagct c" /listShort="yuzO, S1270" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3012332..3012610) /Source="Nicolas_S_feature" /locus_tag="new_3388009_3388287_c" /HighExp="Etha, Gly, S2, Glucon, Pyr, G/S, S1, Lbstat, Cold, HiTm" /AntisenseName="yuxN" /AntisenseCor="-0.128326996122899" /AntisenseRegPval="-1.5" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD, SigH, SigA" /TUshortPSig="0.869, 1, 0.999, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1272" promotor_-35 complement(3012350..3012357) /Source="Nicolas_upshift_promotors" /id="U2590" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.477522477522478" /psig=1 /xcortree=3229 /SigmaFactorBS="tatagtcacaccgtctgttataaaattaaccttATTGTAACt tgtttttttatcATGTATTATTTATATTATAAattgagatgaccgaatggtcaaagct c" /listShort="yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3012436..3013311 /gene="yuxN" /locus_tag="BSU_33030" /old_locus_tag="BSU33030" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_391183.1" /db_xref="EnsemblGenomes-Gn:BSU33030" /db_xref="EnsemblGenomes-Tr:CAB15293" /db_xref="GOA:P40950" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR023772" /db_xref="SubtiList:BG11072" /db_xref="UniProtKB/Swiss-Prot:P40950" /translation="MKEKEKLIIETALKLFAQKGYNSTSVQEIAKECKISKGAFYIYF PSKEALLLSMLNYYYDKTFTRILNIKTKGDSPRTAYRKQLTVLYENILEHKDFISMQL KEGSLPYTEEVEQCAKKIRQSSLQFHIDSLLNIYGKKAEPYTAELCFLIEGISQIYLE CMILLGYTVKPSQLADIIMNRIDDMVKGMSERNDKPFITLEEASSLFGPLTHGRPDPL TESIVKSLRDKINSLNTNSSLELSESLDILEAEMKKKTPKLAIIKGMIHNLTESEALA KDAEQLKYLLKQQHI*" /label="yuxN CDS" gene 3012436..3013311 /gene="yuxN" /locus_tag="BSU_33030" /old_locus_tag="BSU33030" /label="yuxN gene" promotor_-10 complement(3012600..3012619) /Source="Nicolas_upshift_promotors" /id="U2591" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.627372627372627" /psig="0.869130869130869" /xcortree=103 /SigmaFactorBS="ccgttctggggctgtcgcccttcgttttaaTATTTAAAattc gggtaaacgTTTTATCATAATAGTAGTTCagcatagagagaagaagcgcttctttcga a" /listShort="S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3012610) /Source="Nicolas_upshifts" /id="U2591" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.627372627372627" /psig="0.869130869130869" /xcortree=103 /SigmaFactorBS="ccgttctggggctgtcgcccttcgttttaaTATTTAAAattc gggtaaacgTTTTATCATAATAGTAGTTCagcatagagagaagaagcgcttctttcga a" /listShort="S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3012612..3013153) /Source="Nicolas_S_feature" /locus_tag="new_3388289_3388830_c" /HighExp="LBGstat, Cold, S2, Glucon, S1, Pyr, G/S, C30, GM 10, GM-0.1" /AntisenseName="yuxN" /AntisenseCor="-0.341746670828522" /AntisenseRegPval="-8.1" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigH, SigA" /TUshortPSig="1, 0.999, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1273" promotor_-35 complement(3012633..3012640) /Source="Nicolas_upshift_promotors" /id="U2591" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.627372627372627" /psig="0.869130869130869" /xcortree=103 /SigmaFactorBS="ccgttctggggctgtcgcccttcgttttaaTATTTAAAattc gggtaaacgTTTTATCATAATAGTAGTTCagcatagagagaagaagcgcttctttcga a" /listShort="S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3013145..3013163) /Source="Nicolas_upshift_promotors" /id="U2592" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2843 /SigmaFactorBS="ccagcttcggtgtttttttcttcatttctgCTTCAAGTatgt ccaagctcTCCGATAATTCAAGAGAGGagtttgtgtttaagctgttaattttgtcacg t" /listShort="S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3013153) /Source="Nicolas_upshifts" /id="U2592" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2843 /SigmaFactorBS="ccagcttcggtgtttttttcttcatttctgCTTCAAGTatgt ccaagctcTCCGATAATTCAAGAGAGGagtttgtgtttaagctgttaattttgtcacg t" /listShort="S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3013155..3013284) /Source="Nicolas_S_feature" /locus_tag="new_3388832_3388961_c" /HighExp="S2, S1, G/S, Glucon, Pyr, T3.30H, M9-stat, BT, Cold, T4.0H" /AntisenseName="yuxN" /AntisenseCor="-0.30886083736579201" /AntisenseRegPval="-6.6" /CDS_PredictionProba="NA" /TUshortSig="SigH, SigA" /TUshortPSig="0.999, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1274" promotor_-35 complement(3013176..3013183) /Source="Nicolas_upshift_promotors" /id="U2592" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2843 /SigmaFactorBS="ccagcttcggtgtttttttcttcatttctgCTTCAAGTatgt ccaagctcTCCGATAATTCAAGAGAGGagtttgtgtttaagctgttaattttgtcacg t" /listShort="S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3013286 /Source="Nicolas_upshifts" /id="D1707" /incds=0 /nref=30 /ntot=182 /MaxReadThrough="3.14099" /MaxDrop="3.7614" /score="-3.47814442" /energy="-13.6" /TU="NA" /idTUdmin="U2589" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" downshifts complement(3013329) /Source="Nicolas_upshifts" /id="D1708" /incds=0 /nref=1 /ntot=31 /MaxReadThrough="5.30537" /MaxDrop="3.29426" /score="-2.73895091" /energy="-13.6" /TU="U2593,U2594" /idTUdmin="U2591" /TUdmin="-1584" /isTUend="FALSE" /label="downshifts" CDS complement(3013347..3014735) /gene="fumC" /locus_tag="BSU_33040" /old_locus_tag="BSU33040" /EC_number="4.2.1.2" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /function="16.7: Manage energy" /experiment="publication(s) with functional evidences, PMID:2509422, 3130545, 3923430, 9647666, 22914898, 28032445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2509422, 3130545, 3923430, 9647666, 22914898, 28032445; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="fumarate hydratase" /protein_id="NP_391184.1" /db_xref="EnsemblGenomes-Gn:BSU33040" /db_xref="EnsemblGenomes-Tr:CAB15294" /db_xref="GOA:P07343" /db_xref="InterPro:IPR000362" /db_xref="InterPro:IPR005677" /db_xref="InterPro:IPR008948" /db_xref="InterPro:IPR018951" /db_xref="InterPro:IPR020557" /db_xref="InterPro:IPR022761" /db_xref="InterPro:IPR024083" /db_xref="SubtiList:BG10384" /db_xref="UniProtKB/Swiss-Prot:P07343" /translation="MEYRIERDTMGEVKVPADKFWGAQTQRSKENFKIGSEKMPMRVV KAFAILKRSTALANKRLGNLDAEKAEAIAAVCDDVLKGKYDDNFPLVVWQTGSGTQSN MNMNEVVANRATALLKEKNSDQTIHPNDDVNRSQSSNDTFPTAMHVAAVLAVYEQLVP ALDQLRNTLDEKAKAYNDIVKIGRTHLQDATPLTLGQEISGWVHMLDRSKEMILEATD KMRALAIGGTAVGTGINAHPEFGELVSEEITKLTGQTFSSSPNKFHALTSHDEITYAH GALKALAADLMKIANDVRWLASGPRCGIGEIVIPENEPGSSIMPGKVNPTQSEALTMI AAQIMGNDATIGFAASQGNFELNVFKPVIIYNFLQSVQLLSDGMNSFHDKCAVGIEPN KETIQENLSNSLMLVTALNPHIGYENAAKIAKLAHKEGLTLKEAALKLELLTEEQFNE MVKPEDMVKPKA*" /label="fumC CDS" gene complement(3013347..3014735) /gene="fumC" /locus_tag="BSU_33040" /old_locus_tag="BSU33040" /label="fumC gene" upshifts complement(3014759) /Source="Nicolas_upshifts" /id="U2593" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3195 /SigmaFactorBS="gccaagatcgaaaaataaAAAGGATTTtttgtgtcatTGGCG AATTATGATCTATTgaagcaaccgttatggagggatacataaatggaatacagaattg a" /listShort="fumC, S1274, S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3014764..3014782) /Source="Nicolas_upshift_promotors" /id="U2593" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3195 /SigmaFactorBS="gccaagatcgaaaaataaAAAGGATTTtttgtgtcatTGGCG AATTATGATCTATTgaagcaaccgttatggagggatacataaatggaatacagaattg a" /listShort="fumC, S1274, S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3014793..3014801) /Source="Nicolas_upshift_promotors" /id="U2593" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3195 /SigmaFactorBS="gccaagatcgaaaaataaAAAGGATTTtttgtgtcatTGGCG AATTATGATCTATTgaagcaaccgttatggagggatacataaatggaatacagaattg a" /listShort="fumC, S1274, S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3014802..3014987) /gene="yvzF" /locus_tag="BSU_33049" /old_locus_tag="BSU33049" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097786.1" /db_xref="EnsemblGenomes-Gn:BSU33049" /db_xref="EnsemblGenomes-Tr:CAX52692" /db_xref="InterPro:IPR025088" /db_xref="UniProtKB/Swiss-Prot:C0H3R3" /translation="MAQVRLAGKQEEIEQLIRSFEQHYDVSYTSKEYGRTNPKYKYSK DSRVYLELKLKSAKIEK*" /label="yvzF CDS" gene complement(3014802..3014987) /gene="yvzF" /locus_tag="BSU_33049" /old_locus_tag="BSU33049" /label="yvzF gene" downshifts 3014991 /Source="Nicolas_upshifts" /id="D1709" /incds=0 /nref=4 /ntot=100 /MaxReadThrough="1.13377" /MaxDrop="4.4478" /score="-3.47814442" /energy="-13.6" /TU="NA" /idTUdmin="U2595" /TUdmin="-748" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3015031..3015050) /Source="Nicolas_upshift_promotors" /id="U2594" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.566433566433566" /psig="0.996003996003996" /xcortree=2565 /SigmaFactorBS="atgaggtcacctcttatccaaaaccttagtagaggtTATCtt ttcctgttaaaaaAATGATATACTGTGTTAGAGtatttcatggagtaagtttttttat g" /listShort="yvzF, fumC, S1274, S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 3015040..3015046 /Source="Nicolas_upshift_promotors" /id="U2595" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=904 /SigmaFactorBS="ttcataaaaaaacttactccatgaaatactctaacacAGTAT ATcatttttttaacaGGAAAAGATAACctctactaaggttttggataagaggtgacct c" /listShort="gerAA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3015045) /Source="Nicolas_upshifts" /id="U2594" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.566433566433566" /psig="0.996003996003996" /xcortree=2565 /SigmaFactorBS="atgaggtcacctcttatccaaaaccttagtagaggtTATCtt ttcctgttaaaaaAATGATATACTGTGTTAGAGtatttcatggagtaagtttttttat g" /listShort="yvzF, fumC, S1274, S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3015060..3015071 /Source="Nicolas_upshift_promotors" /id="U2595" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=904 /SigmaFactorBS="ttcataaaaaaacttactccatgaaatactctaacacAGTAT ATcatttttttaacaGGAAAAGATAACctctactaaggttttggataagaggtgacct c" /listShort="gerAA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3015063 /Source="Nicolas_upshifts" /id="U2595" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=904 /SigmaFactorBS="ttcataaaaaaacttactccatgaaatactctaacacAGTAT ATcatttttttaacaGGAAAAGATAACctctactaaggttttggataagaggtgacct c" /listShort="gerAA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3015066..3015069) /Source="Nicolas_upshift_promotors" /id="U2594" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.566433566433566" /psig="0.996003996003996" /xcortree=2565 /SigmaFactorBS="atgaggtcacctcttatccaaaaccttagtagaggtTATCtt ttcctgttaaaaaAATGATATACTGTGTTAGAGtatttcatggagtaagtttttttat g" /listShort="yvzF, fumC, S1274, S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3015105..3016553 /gene="gerAA" /locus_tag="BSU_33050" /old_locus_tag="BSU33050" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11418573, 15774895, 16740944, 28605069" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418573, 15774895, 16740944, 28605069; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the GerA germination receptor" /protein_id="NP_391185.2" /db_xref="EnsemblGenomes-Gn:BSU33050" /db_xref="EnsemblGenomes-Tr:CAB15295" /db_xref="GOA:P07868" /db_xref="InterPro:IPR004995" /db_xref="SubtiList:BG10385" /db_xref="UniProtKB/Swiss-Prot:P07868" /translation="MEQTEFKEYIHDNLALVLPKLKENDDLVKNKKMLANGLVFYYLY FSEMTDENKVSEAIKTLIKDEETLTLDQVKKRLDQLDARPVETAKKTIESILNGNCAV FINGLDKAYILTTGKKKTRSLTEPTTEKVVRGPKVAFVEDIDTNLALIRQRTSHPKLI TKKIMIGENKLKPAAIMYIEGKAKKSVIKEVKARLKNIQLEDIQDSGTLEELIEDNKY SPFPQIQNTERPDKVSSALFNGRVAILVDSSPFVLLVPVSLGILMQSPDDYYERWISA SLIRSLRFASIFITLFLSSIYITLVSFHQGLLPTALAVTISANRENVPFPPIFEALLM EVTIELLREAGLRLPNPLGQTIGLVGGVVIGQAAVEANLVSSILVIVVSVIALASFTV PQYGMGLSFRVLRFISMFSAAILGLYGIILFMLVVYTHLTRQTSFGSPYFSPNGFFSL KNTDDSIIRLPIKNKPKEVNNPNEPKTDSTET*" /label="gerAA CDS" gene 3015105..3016553 /gene="gerAA" /locus_tag="BSU_33050" /old_locus_tag="BSU33050" /label="gerAA gene" S_feature complement(3016101..3018744) /Source="Nicolas_S_feature" /locus_tag="new_3391778_3394421_c" /HighExp="Cold, H2O2, G135, G180, Paraq, G150, Oxctl, T-5.40H, LBGstat, T-4.40H" /AntisenseName="gerAC" /AntisenseCor="-9.7163861003102397E-2" /AntisenseRegPval="-1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1275" CDS 3016522..3017619 /gene="gerAB" /locus_tag="BSU_33060" /old_locus_tag="BSU33060" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15774895, 15849754, 16740944, 16850406, 28605069" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15774895, 15849754, 16740944, 16850406, 28605069; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the germination receptor GerA; putative transporter" /protein_id="NP_391186.1" /db_xref="EnsemblGenomes-Gn:BSU33060" /db_xref="EnsemblGenomes-Tr:CAB15296" /db_xref="GOA:P07869" /db_xref="InterPro:IPR004761" /db_xref="SubtiList:BG10386" /db_xref="UniProtKB/Swiss-Prot:P07869" /translation="MSQKQTPLKLNTFQGISIVANTMLGAGLLTLPRALTTKANTPDG WITLILEGFIFIFFIYLNTLIQKKHQYPSLFEYLKEGLGKWIGSIIGLLICGYFLGVA SFETRAMAEMVKFFLLERTPIQVIILTFICCGIYLMVGGLSDVSRLFPFYLTVTIIIL LIVFGISFKIFDINNLRPVLGEGLGPIANSLTVVSISFLGMEVMLFLPEHMKKKKYTF RYASLGFLIPIILYILTYIIVVGALTAPEVKTLIWPTISLFQSFELKGIFIERFESFL LVVWIIQFFTTFVIYGYFAANGLKKTFGLSTKTSMVIIGITVFYFSLWPDDANQVMMY SDYLGYIFVSLFLLPFILFFIVALKRRITTK*" /label="gerAB CDS" gene 3016522..3017619 /gene="gerAB" /locus_tag="BSU_33060" /old_locus_tag="BSU33060" /label="gerAB gene" CDS 3017616..3018737 /gene="gerAC" /locus_tag="BSU_33070" /old_locus_tag="BSU33070" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11418573, 15774895, 16740944, 28605069" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418573, 15774895, 16740944, 28605069; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the germination receptor GerA" /protein_id="NP_391187.1" /db_xref="EnsemblGenomes-Gn:BSU33070" /db_xref="EnsemblGenomes-Tr:CAB15297" /db_xref="GOA:P07870" /db_xref="InterPro:IPR008844" /db_xref="SubtiList:BG10387" /db_xref="UniProtKB/Swiss-Prot:P07870" /translation="MKIRILCMFICTLLLSGCWDSENIEELSLVIGIGLDKPDDENLE LTQQILVPKIISAKEGSSSDPTQLSITKGKTVHQMMRTSALKHKPTFSQHLRLILLSK SVIADQIGMDAIINQFVRDNGTRRSSYVFITNGRTKDIFNMNDEGEPASNVIYDLTEN NKVTIRTMEPVTLGEISEHLTSDDSFLIPHVGKENGKLAINGASIIKNKLWHRDLTPI EVQNISLFSGTVEGGVIDLKRDGHLFSYEVYSSNRKIKTAYKDGKFKFTVTRNIEGRL SEDWNPNEDSFKDSYIKSIEKTVEKRVHETVTSFITEKLQKEIKADVTGLGNEVRIHY PQKWKKISRKWDDDYFSNAEIDYRVNVIVRDFGTKGANK*" /label="gerAC CDS" gene 3017616..3018737 /gene="gerAC" /locus_tag="BSU_33070" /old_locus_tag="BSU33070" /label="gerAC gene" CDS complement(3018745..3019380) /gene="liaR" /locus_tag="BSU_33080" /old_locus_tag="BSU33080" /function="16.6: Maintain" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11717295, 15273097, 16816187, 17660417, 17921301, 23279150, 23326432, 24666271" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15273097, 16816187, 17660417, 17921301, 23279150, 23326432, 24666271; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YvqE] responding to cell wall stress" /protein_id="NP_391188.1" /db_xref="EnsemblGenomes-Gn:BSU33080" /db_xref="EnsemblGenomes-Tr:CAB15298" /db_xref="GOA:O32197" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG14133" /db_xref="UniProtKB/Swiss-Prot:O32197" /translation="MIRVLLIDDHEMVRMGLAAFLEAQPDIEVIGEASDGSEGVRLAV ELSPDVILMDLVMEGMDGIEATKQICRELSDPKIIVLTSFIDDDKVYPVIEAGALSYL LKTSKAAEIADAIRAASKGEPKLESKVAGKVLSRLRHSGENALPHESLTKRELEILCL IAEGKTNKEIGEELFITIKTVKTHITNILSKLDVSDRTQAAVYAHRNHLVN*" /label="liaR CDS" gene complement(3018745..3019380) /gene="liaR" /locus_tag="BSU_33080" /old_locus_tag="BSU33080" /label="liaR gene" CDS complement(3019358..3020440) /gene="liaS" /locus_tag="BSU_33090" /old_locus_tag="BSU33090" /function="16.12: Sense" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11717295, 15273097, 16816187, 17660417, 17921301, 23279150, 23326432, 24666271" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15273097, 16816187, 17660417, 17921301, 23279150, 23326432, 24666271; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [LiaR(YvqC)] sensing cell wall stress" /protein_id="NP_391189.1" /db_xref="EnsemblGenomes-Gn:BSU33090" /db_xref="EnsemblGenomes-Tr:CAB15299" /db_xref="GOA:O32198" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR017202" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG14134" /db_xref="UniProtKB/Swiss-Prot:O32198" /translation="MRKKMLASLQWRAIRMTTGISLLLFVCLISFMMFYYRLDPLVLL SSSWFGIPFILILLLISVTVGFASGYMYGNRLKTRIDTLIESILTFENGNFAYRIPPL GDDEIGLAADQLNEMAKRVELQVASLQKLSNERAEWQAQMKKSVISEERQRLARDLHD AVSQQLFAISMMTSAVLEHVKDADDKTVKRIRMVEHMAGEAQNEMRALLLHLRPVTLE GKGLKEGLTELLDEFRKKQPIDIEWDIQDTAISKGVEDHLFRIVQEALSNVFRHSKAS KVTVILGIKNSQLRLKVIDNGKGFKMDQVKASSYGLNSMKERASEIGGVAEVISVEGK GTQIEVKVPIFPEEKGENERDSSIID*" /label="liaS CDS" gene complement(3019358..3020440) /gene="liaS" /locus_tag="BSU_33090" /old_locus_tag="BSU33090" /label="liaS gene" CDS complement(3020437..3021162) /gene="liaF" /locus_tag="BSU_33100" /old_locus_tag="BSU33100" /function="16.6: Maintain" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15273097, 15849754, 16816187, 16850406, 17660417, 17921301, 23279150, 23326432" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15273097, 15849754, 16816187, 16850406, 17660417, 17921301, 23279150, 23326432; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="membrane component associated to the LiaRS two-component system" /protein_id="NP_391190.1" /db_xref="EnsemblGenomes-Gn:BSU33100" /db_xref="EnsemblGenomes-Tr:CAB15300" /db_xref="GOA:O32199" /db_xref="InterPro:IPR016975" /db_xref="InterPro:IPR024425" /db_xref="SubtiList:BG14135" /db_xref="UniProtKB/Swiss-Prot:O32199" /translation="MTKKQLLGLIIALFGISMFLQIIGIGDLLFWPLFFLIAGYFLKK YSRDWLGSVMYIFAAFLFLKNLFSITFNLFGYAFAAFLIYAGYRLIKGKPIFEPNEKQ VNLNKKEHHEPPKDVKHPDMRSFFIGELQMMKQPFDLNDLNVSGFIGDIKIDLSKAMI PEGESTIVISGVIGNVDIYVPSDLEVAVSSAVFIGDINLIGSKKSGLSTKVYAASTDF SESKRRVKVSVSLFIGDVDVKYV*" /label="liaF CDS" gene complement(3020437..3021162) /gene="liaF" /locus_tag="BSU_33100" /old_locus_tag="BSU33100" /label="liaF gene" CDS complement(3021196..3022068) /gene="liaG" /locus_tag="BSU_33110" /old_locus_tag="BSU33110" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15273097, 16816187, 23326432" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15273097, 16816187, 23326432; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="sensor of antibiotic stress on the cell wall" /protein_id="NP_391191.2" /db_xref="EnsemblGenomes-Gn:BSU33110" /db_xref="EnsemblGenomes-Tr:CAB15301" /db_xref="InterPro:IPR025164" /db_xref="SubtiList:BG14136" /db_xref="UniProtKB/Swiss-Prot:O32200" /translation="MKKMLGKLLITAGILVFFAVVVKDVFAAGLGFINGTEADSASAS PRDIDSMVIESDSKDVRIIAEERSDISAGISGDSGKLFVTENKRKLELTVKEKEFQFL NGFNRSTLIVRLPYDYKGDLAVRTSSGDVSVAGNDHLALSGLNAVSASGNTSVTDVRI QDLKVKASSGDVSISNTVSKTAGIDLASGDANLVHVSGSLDVKMTSGDFNAVLKKVTG PVSVTLTSGDANVSLPQNGSFAVNALSASGDVSSPYSFADKGHKEQHHITGTQGSGRH PIDIKTDSGDLAIR*" /label="liaG CDS" gene complement(3021196..3022068) /gene="liaG" /locus_tag="BSU_33110" /old_locus_tag="BSU33110" /label="liaG gene" promotor_-10 complement(3022087..3022106) /Source="Nicolas_upshift_promotors" /id="U2596" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=2136 /SigmaFactorBS="cggaacggggaaggatttgcggtcaagtccttcccttccgca cGTATcaattcgcaagcttTTCCTTTATAATAGAATGAAtgagaaggatgaaaccgaa t" /listShort="liaG, liaF, liaS, liaR, S1275" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3022107) /Source="Nicolas_upshifts" /id="U2596" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=2136 /SigmaFactorBS="cggaacggggaaggatttgcggtcaagtccttcccttccgca cGTATcaattcgcaagcttTTCCTTTATAATAGAATGAAtgagaaggatgaaaccgaa t" /listShort="liaG, liaF, liaS, liaR, S1275" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3022121..3022124) /Source="Nicolas_upshift_promotors" /id="U2596" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=2136 /SigmaFactorBS="cggaacggggaaggatttgcggtcaagtccttcccttccgca cGTATcaattcgcaagcttTTCCTTTATAATAGAATGAAtgagaaggatgaaaccgaa t" /listShort="liaG, liaF, liaS, liaR, S1275" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3022169..3022846) /gene="liaH" /locus_tag="BSU_33120" /old_locus_tag="BSU33120" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15273097, 16816187, 23874669, 24666271, 28546427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15273097, 16816187, 23874669, 24666271, 28546427; Product type f: factor" /codon_start=1 /transl_table=11 /product="modulator of liaIHGFSR (yvqIHGFEC) operon expression" /protein_id="NP_391192.1" /db_xref="EnsemblGenomes-Gn:BSU33120" /db_xref="EnsemblGenomes-Tr:CAB15302" /db_xref="GOA:O32201" /db_xref="InterPro:IPR007157" /db_xref="SubtiList:BG14137" /db_xref="UniProtKB/Swiss-Prot:O32201" /translation="MVLKRIRDMFVASVHEGLDKMENPKVMLNQYVRDMESDIAKAKQ TIVKQHTIAYQFKKKYEEAAEVAGKRKNQAQLAFDAGEEELAKKALTEMKYLEGKAAE HKASYEQANSQLADLKEQLAALETKLQDVKDKKQALIARANAAKAKEHMNTTFDKIDS ESAYREFLRIENRIEEMEIRANYSKSAEAGTELTRKEFADDVEAEIEKMRTLSLQKSD QTKAANE*" /label="liaH CDS" gene complement(3022169..3022846) /gene="liaH" /locus_tag="BSU_33120" /old_locus_tag="BSU33120" /label="liaH gene" downshifts complement(3022185) /Source="Nicolas_upshifts" /id="D1710" /incds=0 /nref=2 /ntot=28 /MaxReadThrough="3.84852" /MaxDrop="3.1352" /score="-8.3477012" /energy="-4.5" /TU="U2597" /idTUdmin="U2598" /TUdmin=1243 /isTUend="FALSE" /label="downshifts" CDS complement(3022873..3023253) /gene="liaI" /locus_tag="BSU_33130" /old_locus_tag="BSU33130" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15273097, 15849754, 16816187, 16850406, 22720735, 24666271, 28546427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15273097, 15849754, 16816187, 16850406, 22720735, 24666271, 28546427; Product type s: structure" /codon_start=1 /transl_table=11 /product="membrane anchor for the phage-shock protein A homolog LiaH" /protein_id="NP_391193.1" /db_xref="EnsemblGenomes-Gn:BSU33130" /db_xref="EnsemblGenomes-Tr:CAB15303" /db_xref="GOA:O32202" /db_xref="SubtiList:BG14138" /db_xref="UniProtKB/Swiss-Prot:O32202" /translation="MKINKKTIGGFLLIVFGISVFFGGGSFGFIIPLAIGSLMTYAGI KRFAAGKTITGIIVGGIGAIMLICSLPFVVGIALAAAMVYYGWKLMKNGSADNGVSSF DPEPASAAYQSHFDDEWEEFLKKK*" /label="liaI CDS" gene complement(3022873..3023253) /gene="liaI" /locus_tag="BSU_33130" /old_locus_tag="BSU33130" /label="liaI gene" promotor_-10 complement(3023276..3023295) /Source="Nicolas_upshift_promotors" /id="U2597" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig="0.91008991008991" /xcortree=648 /SigmaFactorBS="cgagatacgactccggtcttatataaaaatcaatctctgatt cGTTTtgcatatcttccaaCTTGTATAAGATGAAGACAAggaaaacgaaaggaggatc t" /listShort="liaI, liaH, liaG, liaF, liaS, liaR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3023296) /Source="Nicolas_upshifts" /id="U2597" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig="0.91008991008991" /xcortree=648 /SigmaFactorBS="cgagatacgactccggtcttatataaaaatcaatctctgatt cGTTTtgcatatcttccaaCTTGTATAAGATGAAGACAAggaaaacgaaaggaggatc t" /listShort="liaI, liaH, liaG, liaF, liaS, liaR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3023310..3023313) /Source="Nicolas_upshift_promotors" /id="U2597" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig="0.91008991008991" /xcortree=648 /SigmaFactorBS="cgagatacgactccggtcttatataaaaatcaatctctgatt cGTTTtgcatatcttccaaCTTGTATAAGATGAAGACAAggaaaacgaaaggaggatc t" /listShort="liaI, liaH, liaG, liaF, liaS, liaR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3023415..3024683) /gene="yvqJ" /locus_tag="BSU_33140" /old_locus_tag="BSU33140" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15273097, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux protein" /protein_id="NP_391194.1" /db_xref="EnsemblGenomes-Gn:BSU33140" /db_xref="EnsemblGenomes-Tr:CAB15304" /db_xref="GOA:O32203" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG14139" /db_xref="UniProtKB/Swiss-Prot:O32203" /translation="MVNLIESDSIWKRNFNYLFFSRIVKISGDMFAFNSILWFLIYDG KGAIGTALLIAVTFLPEAVLAPVTGPFMKQTTLKFWMYFSDLTRAAIVLIIPLCHFAG FSPLWFVMTLMIVHSATGAAYNPASIALIPQIVNEQGIQKANAVLQSSAQIVRLGAVT LCGAFLTFISPSYTMLIALVLYLVSGFLVLFIKYTAVESQSESAVVTQRGTYIGRLKR GFRLVRKHQILYPLAIYCIFMNFAAAPWEALSAVYVAEDLNGQPIVYSLLKATTAAGA FLLGFVLAKVKVNRYGLLFVTAGIIEGFAFFITGMNTFLPLVFFAAFTFGAAVSAVNV PEYTIIQTSVDSEDQPQVYAVIHMISNISIPAGAVICGYAANAFGSGKVIAVGGIVEI IAGIGILLFTKLAKAERSDLIKEREASVHL*" /label="yvqJ CDS" gene complement(3023415..3024683) /gene="yvqJ" /locus_tag="BSU_33140" /old_locus_tag="BSU33140" /label="yvqJ gene" downshifts complement(3023428) /Source="Nicolas_upshifts" /id="D1711" /incds=0 /nref=78 /ntot=164 /MaxReadThrough="0.70612" /MaxDrop="4.80625" /score="32.7496145" /energy="-12.9" /TU="NA" /idTUdmin="U2598" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3024717..3024736) /Source="Nicolas_upshift_promotors" /id="U2598" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=482 /SigmaFactorBS="attttacgacaaaaaatgaaccttatgaatTATTGACTgaaa aatggaaaaaTGAGATATTGTAATAAATAGatgtaaaaaataggcaacggggggctct g" /listShort="yvqJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3024728) /Source="Nicolas_upshifts" /id="U2598" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=482 /SigmaFactorBS="attttacgacaaaaaatgaaccttatgaatTATTGACTgaaa aatggaaaaaTGAGATATTGTAATAAATAGatgtaaaaaataggcaacggggggctct g" /listShort="yvqJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3024751..3024758) /Source="Nicolas_upshift_promotors" /id="U2598" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=482 /SigmaFactorBS="attttacgacaaaaaatgaaccttatgaatTATTGACTgaaa aatggaaaaaTGAGATATTGTAATAAATAGatgtaaaaaataggcaacggggggctct g" /listShort="yvqJ" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3024854) /Source="Nicolas_upshifts" /id="D1712" /incds=0 /nref=33 /ntot=211 /MaxReadThrough="1.54601" /MaxDrop="4.92923" /score="51.1311697" /energy="-17.1" /TU="NA" /idTUdmin="U2599" /TUdmin=4 /isTUend="TRUE" /label="downshifts" CDS complement(3024860..3025441) /gene="yvqK" /locus_tag="BSU_33150" /old_locus_tag="BSU33150" /EC_number="2.5.1.17" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12869542, 14704351, 17588214, 19933577, 21514283; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ATP:cob(I)alamin adenosyltransferase" /protein_id="NP_391195.2" /db_xref="EnsemblGenomes-Gn:BSU33150" /db_xref="EnsemblGenomes-Tr:CAB15305" /db_xref="GOA:O34899" /db_xref="InterPro:IPR016030" /db_xref="InterPro:IPR029499" /db_xref="InterPro:IPR036451" /db_xref="PDB:1RTY" /db_xref="SubtiList:BG14140" /db_xref="UniProtKB/Swiss-Prot:O34899" /translation="MKLYTKTGDKGQTGLVGGRTDKDSLRVESYGTIDELNSFIGLAL AELSGQPGFEDLTAELLTIQHELFDCGGDLAIVTERKDYKLTEESVSFLETRIDAYTA EAPELKKFILPGGSKCASLLHIARTITRRAERRVVALMKSEEIHETVLRYLNRLSDYF FAAARVVNARSGIGDVEYERSAIVFRDRNSSES*" /label="yvqK CDS" gene complement(3024860..3025441) /gene="yvqK" /locus_tag="BSU_33150" /old_locus_tag="BSU33150" /label="yvqK gene" CDS complement(3025464..3026792) /gene="yvrA" /locus_tag="BSU_33160" /old_locus_tag="BSU33160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14704351; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative vitamin B12 transport system, ATPase component" /protein_id="NP_391196.1" /db_xref="EnsemblGenomes-Gn:BSU33160" /db_xref="EnsemblGenomes-Tr:CAB15306" /db_xref="GOA:O34631" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG14141" /db_xref="UniProtKB/Swiss-Prot:O34631" /translation="MKAEGLSGGYGDSRLINNVSLTVEKGEFLGILGPNGSGKTTLLH LLTGTLPAKKGRVYLAGKLLADYKPKELAQIMAVLPQKMDQAFTFTVEETVAFGRYPF QTGLFRQQTEKGEAIVQEAMEQTGVADFAQKPIRELSGGEQQRVYLAQALAQQPRILF LDEPTNFLDLAYQKDLLDLIKRLTRESGLAAVSVFHDLNTASLYCDGLMFMKNGTAGP KQKPEYAVTEQSIKAVYDTDVTALVHQSSPKPMIVIQPEKDSVKRQSIPFEALLQAGR DDILLQTEIPLRTLSSTPIGAGFSWSRTLIHKRLPDQPDPIEGLTACLSESGFQLQET CAMASSERLDRFVYRTYEDGELSVFICVQTGFSIWILINGYAADQFFIKALMAAEAER TKVLGDGGGTGDILIAATQTQQSENIEQRLNQLIKKGTAECIKEAAELFE*" /label="yvrA CDS" gene complement(3025464..3026792) /gene="yvrA" /locus_tag="BSU_33160" /old_locus_tag="BSU33160" /label="yvrA gene" CDS complement(3026792..3027853) /gene="yvrB" /locus_tag="BSU_33170" /old_locus_tag="BSU33170" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14704351, 15849754, 16850406, 25917914; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative vitamin B12 permease" /protein_id="NP_391197.1" /db_xref="EnsemblGenomes-Gn:BSU33170" /db_xref="EnsemblGenomes-Tr:CAB15307" /db_xref="GOA:O34451" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG14142" /db_xref="UniProtKB/Swiss-Prot:O34451" /translation="MRKAFTRIRLRNNRYAAYIIGFSFLAVSIILGISCGSLHIPIPA VFRVFWHQGFGGSIGSDDPMYTNIMMNIRLPRVVLAALVGAALSIAGAAFQGLLKNPL ADPYTLGVSSGASVGAVVTLFLGLHLPVIGGFTLPVLSVAAALATMAAVLFFSRLVHA SMSVSTLILTGVITNSFLGAFISLIIALTGDNLLPIVHWLLGSVSMRGWSYVILFLPF FLLGTILLIINGRELNVMTYGEDKAKLLGVSVQQRKMMILIAGSLLTGSAVAVSGTIG FVGLVIPHITRLLWGTDHRHLLPLSALLGAGFLVLADLLSRTIIEPIELPIGIITSLA GAPVFALILIRQHRGGRSL*" /label="yvrB CDS" gene complement(3026792..3027853) /gene="yvrB" /locus_tag="BSU_33170" /old_locus_tag="BSU33170" /label="yvrB gene" CDS complement(3027816..3028760) /gene="yvrC" /locus_tag="BSU_33180" /old_locus_tag="BSU33180" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14704351, 25917914; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative lipoprotein binding vitamin B12" /protein_id="NP_391198.1" /db_xref="EnsemblGenomes-Gn:BSU33180" /db_xref="EnsemblGenomes-Tr:CAB15308" /db_xref="GOA:O34805" /db_xref="InterPro:IPR002491" /db_xref="SubtiList:BG14143" /db_xref="UniProtKB/Swiss-Prot:O34805" /translation="MKKRAGIWAALLLAAVMLAGCGNPADQKDSKAKQKTEVFPVTID DASNQDVTIKKEPKKIVSLMPSNTEITYALGLGDKVVGVTTNDTYPKEVKKVEKVGDM NVNVEKVISLKPDLVLAHESSMSASADAIKQLKDAGITVLTVNDAQSFSEVYKSIEMI GEAGGAEKKADQLVKSMKSDLKDIQEKAKTISKDEEKSVFIEVSPDPDIYTTGKDTFM NEMLNVIHAKNAAADQTGWVQMTDEAIVKLNPDAIVTTDGVKAKAVEKRDGWSEINAV KHHRVYDVDPDLVTRSGPRLIEGVEELAESIYPDTFKE*" /label="yvrC CDS" gene complement(3027816..3028760) /gene="yvrC" /locus_tag="BSU_33180" /old_locus_tag="BSU33180" /label="yvrC gene" S_feature complement(3028761..3029030) /Source="Nicolas_S_feature" /locus_tag="new_3404438_3404707_c" /HighExp="LBGtran, LBGexp, Etha, LPh, S3, Lbexp, G180, dia0, HPh, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="0.956, 1" /TUlongSig="SigA" /TUlongPSig="0.925" /label="S1276" misc_RNA complement(3028869..3028999) /gene="srbL" /locus_tag="BSU_misc_RNA_85" /product="putative coenzyme B12 (AdoCbl) riboswitch" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14704351, 17038623, 21140903, 25917914; Product type n: RNA" /function="16.3: Control" /label="srbL RNA" gene complement(3028869..3028999) /gene="srbL" /locus_tag="BSU_misc_RNA_85" /label="srbL gene" promotor_-10 complement(3029007..3029026) /Source="Nicolas_upshift_promotors" /id="U2599" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.899100899100899" /psig="0.956043956043956" /xcortree=2215 /SigmaFactorBS="tttgcttccatacacaatatggggaaaagtcattcaggacaC ATATACAagcctgtcagtcataTAGTATAATTACTCCGAAAAacggatacgaatgtca a" /listShort="S1276, yvrC, yvrB, yvrA, yvqK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3029030) /Source="Nicolas_upshifts" /id="U2599" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.899100899100899" /psig="0.956043956043956" /xcortree=2215 /SigmaFactorBS="tttgcttccatacacaatatggggaaaagtcattcaggacaC ATATACAagcctgtcagtcataTAGTATAATTACTCCGAAAAacggatacgaatgtca a" /listShort="S1276, yvrC, yvrB, yvrA, yvqK" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3029032..3029959) /Source="Nicolas_S_feature" /locus_tag="new_3404709_3405636_c" /HighExp="Etha, B60, Sw, M9-stat, B36, C30, C90, Salt, G135, Gly" /AntisenseName="yvrD" /AntisenseCor="1.5286196477289399E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.925" /label="S1277" promotor_-35 complement(3029042..3029049) /Source="Nicolas_upshift_promotors" /id="U2599" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.899100899100899" /psig="0.956043956043956" /xcortree=2215 /SigmaFactorBS="tttgcttccatacacaatatggggaaaagtcattcaggacaC ATATACAagcctgtcagtcataTAGTATAATTACTCCGAAAAacggatacgaatgtca a" /listShort="S1276, yvrC, yvrB, yvrA, yvqK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3029092..3029099 /Source="Nicolas_upshift_promotors" /id="U2600" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.868131868131868" /psig="0.992007992007992" /xcortree=1946 /SigmaFactorBS="atgacttttccccatattgtgtatggaagcaaaaTCCTCGTA aacactaaatttgaTCTTGTATACTTAATACCATcatctatcaaaaggaatgattctt a" /listShort="yvrD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3029114..3029133 /Source="Nicolas_upshift_promotors" /id="U2600" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.868131868131868" /psig="0.992007992007992" /xcortree=1946 /SigmaFactorBS="atgacttttccccatattgtgtatggaagcaaaaTCCTCGTA aacactaaatttgaTCTTGTATACTTAATACCATcatctatcaaaaggaatgattctt a" /listShort="yvrD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3029118 /Source="Nicolas_upshifts" /id="U2600" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.868131868131868" /psig="0.992007992007992" /xcortree=1946 /SigmaFactorBS="atgacttttccccatattgtgtatggaagcaaaaTCCTCGTA aacactaaatttgaTCTTGTATACTTAATACCATcatctatcaaaaggaatgattctt a" /listShort="yvrD" /GFF_Attribute="listLong" /label="upshifts" CDS 3029158..3029949 /gene="yvrD" /locus_tag="BSU_33190" /old_locus_tag="BSU33190" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9922248; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391199.1" /db_xref="EnsemblGenomes-Gn:BSU33190" /db_xref="EnsemblGenomes-Tr:CAB15309" /db_xref="GOA:O34782" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG14144" /db_xref="UniProtKB/Swiss-Prot:O34782" /translation="MDLQLKEKLVLITGSTSGIGKAAAKSFLQEGAAVIVNGRKQETV DRTIEELSGYGTVHGAAADLSKTDEAAAFIEKVNEIGDIDILVNNLGFFEVKDFADVT DEEWNQYFEVNVMSAVRTSRHFLPKMLAKNSGRILNIASEAGVKPLPTMIPYSMTKTA LISLSRGMAEMTKGTNVTVNSVLPGPTWTEGVASYMEGAAQAAGQDTDTFIKDYFKVN EPTSLIQRYATAEEVANTIVFLASDAASAINGTAQRVEGGIIRSL*" /label="yvrD CDS" gene 3029158..3029949 /gene="yvrD" /locus_tag="BSU_33190" /old_locus_tag="BSU33190" /label="yvrD gene" downshifts 3029820 /Source="Nicolas_upshifts" /id="D1713" /incds=1 /nref=2 /ntot=89 /MaxReadThrough="6.202" /MaxDrop="3.35017" /score="36.8938178" /energy="-12" /TU="U2600" /idTUdmin="U2600" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" downshifts 3029930 /Source="Nicolas_upshifts" /id="D1714" /incds=0 /nref=105 /ntot=218 /MaxReadThrough="2.44739" /MaxDrop="6.33457" /score="36.8938178" /energy="-12" /TU="NA" /idTUdmin="U2600" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3029987..3030865) /gene="yvrE" /locus_tag="BSU_33200" /old_locus_tag="BSU33200" /EC_number="3.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sugar lactone lactonase" /protein_id="NP_391200.1" /db_xref="EnsemblGenomes-Gn:BSU33200" /db_xref="EnsemblGenomes-Tr:CAB15310" /db_xref="GOA:O34940" /db_xref="InterPro:IPR005511" /db_xref="InterPro:IPR011042" /db_xref="InterPro:IPR013658" /db_xref="SubtiList:BG14145" /db_xref="UniProtKB/Swiss-Prot:O34940" /translation="MDAVLEADTRAVIGEGPLWDEENGRLYWVDILGSELHIFDPEEK INRSIKFKSFVTALAKYSKDELIMTMKDGFYLYHLRDDSLEKIKQPKDMHESLRFNDA KCDPYGRLWAGTTSMEGEQKQASLYRLNLDGSLVKIKDQVSTSNGLDWDRERNLMYYI DTPTQEIVRYSYDPQSGDVSNPEPVYRFDQSDGLPDGMTIDQNGMLWVALFGGSRVVH IDPFQKKEINSISVPAKYVTCCAFGGRDLKTLYITTATEQMTEKERYEQPHAGGLFSA QLETGGYQPVPFAGDV*" /label="yvrE CDS" gene complement(3029987..3030865) /gene="yvrE" /locus_tag="BSU_33200" /old_locus_tag="BSU33200" /label="yvrE gene" downshifts complement(3030004) /Source="Nicolas_upshifts" /id="D1715" /incds=0 /nref=31 /ntot=260 /MaxReadThrough="7.17016" /MaxDrop="5.74101" /score="29.8014794" /energy="-12" /TU="U2601" /idTUdmin="U2602" /TUdmin="-20" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3030889..3030907) /Source="Nicolas_upshift_promotors" /id="U2601" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=160 /SigmaFactorBS="cggtcattaccatcctttttaaaaaacaataaacatcaagtG GTTTGGacacctctttgccGGGAATAACAATATATAGActgaagctaaagaggtgtaa c" /listShort="yvrE, S1277, S1276, yvrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3030908) /Source="Nicolas_upshifts" /id="U2601" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=160 /SigmaFactorBS="cggtcattaccatcctttttaaaaaacaataaacatcaagtG GTTTGGacacctctttgccGGGAATAACAATATATAGActgaagctaaagaggtgtaa c" /listShort="yvrE, S1277, S1276, yvrC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3030921..3030927) /Source="Nicolas_upshift_promotors" /id="U2601" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=160 /SigmaFactorBS="cggtcattaccatcctttttaaaaaacaataaacatcaagtG GTTTGGacacctctttgccGGGAATAACAATATATAGActgaagctaaagaggtgtaa c" /listShort="yvrE, S1277, S1276, yvrC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3030937..3032679) /gene="yvrG" /locus_tag="BSU_33210" /old_locus_tag="BSU33210" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 16306698, 25879813" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 16306698, 25879813; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase YvrG [cellwall processes and sublancin production and immunity(YvrH)]" /protein_id="NP_391201.2" /db_xref="EnsemblGenomes-Gn:BSU33210" /db_xref="EnsemblGenomes-Tr:CAB15311" /db_xref="GOA:O34989" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG14146" /db_xref="UniProtKB/Swiss-Prot:O34989" /translation="MRLRWKFLFHFFGQMLIVILLLTVMLVASFFYLDARFSDAESNS GLTKATTDTLEAYLDVNEDGTWEVDNFLKKSVDKQHGWMQIIDSEGNTDYSYGVPKDV PGTYTKKELLSIYKTKKLHNYKLNYWAINIEDKSYLLLSGWKSKSEQLLTSVEKREQK IDSLAHYKSSTIDYIKRKKGAIYLLDSNGKILDSINSTKSERKTMNQLELLKYSSKPW NYKREISVKILNKDRWMVATVPNPVYVTDQEFNKSFLKVVLKAMFLVMAVLFMYIIWM TVWYMFRFGLPIFHTIRWLVNLSKGKLEEPRNREGRPVSKNKKGKIKQPYRFFGEIFE SMDQLTETLRRDKRNREKIQATREEWIAGLSHDLKTPLSSIYGYSMMLESKQYDWSPE EVKEMGQVVREKSEYMSKLIEDLNLTYRLKNDALPIERKLTSLIPFFKNVIEDFKKNP FSEGYDISFVSKEEHIEFALDEAWFRRILENLLGNAVKHNGKGTEIQVILEQTKNHIS LKVKDNGKGMDEETITHLFNRYYRGTNTKDSTAGTGLGLAIAKELVHLHNGTIHVNSR TNIGTVITILFKKQ*" /label="yvrG CDS" gene complement(3030937..3032679) /gene="yvrG" /locus_tag="BSU_33210" /old_locus_tag="BSU33210" /label="yvrG gene" CDS complement(3032676..3033389) /gene="yvrH" /locus_tag="BSU_33221" /old_locus_tag="BSU33221" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 16306698, 25879813" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 16306698, 25879813; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase YvrG [cellwall processes and sublancin production and immunity(YvrG)]" /protein_id="NP_391202.2" /db_xref="EnsemblGenomes-Gn:BSU33221" /db_xref="EnsemblGenomes-Tr:CAB15312" /db_xref="GOA:P94504" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12452" /db_xref="UniProtKB/Swiss-Prot:P94504" /translation="MENASILIVDDEKAIVDMIKRVLEKEGYRNILDAASAEEAIPVV KANKVDLIVLDVMMGGMSGFEACTLIREYSDAPIFFLTARSSDADKLSGFAVGADDYI TKPFNPLELAARIRAHLKRTYQSKETSSNQTYTYDYFTFSPQNAELIVGGEAVACSAQ LLQLLQYFCEHPNVVLSKDQIYEKVWGYPSYGDNNTVMVHIRKLREKIERDPSNPEYI VTVRGLGYRFIPNPEGKRS*" /label="yvrH CDS" gene complement(3032676..3033389) /gene="yvrH" /locus_tag="BSU_33221" /old_locus_tag="BSU33221" /label="yvrH gene" misc_feature complement(3033420..3033439) /Source="Nicolas_upshift_promotors" /id="U2602" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.629370629370629" /psig="0.925074925074925" /xcortree=2348 /SigmaFactorBS="ccttttttgctgttttgatttgccaaggctccaatgtattca aaaatgtaccataaataAACGATATAATGATAAGATGaaaaaaacagtgacagaaagg a" /listShort="yvrH, yvrG, yvrE" /listLong="S1277, S1276, yvrC" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3033438) /Source="Nicolas_upshifts" /id="U2602" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.629370629370629" /psig="0.925074925074925" /xcortree=2348 /SigmaFactorBS="ccttttttgctgttttgatttgccaaggctccaatgtattca aaaatgtaccataaataAACGATATAATGATAAGATGaaaaaaacagtgacagaaagg a" /listShort="yvrH, yvrG, yvrE" /listLong="S1277, S1276, yvrC" /label="upshifts" CDS complement(3033542..3033781) /gene="rsoA" /locus_tag="BSU_33222" /old_locus_tag="BSU33222" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18573182, 19047353, 27558998" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18573182, 19047353, 27558998; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of sigma-O" /protein_id="YP_003097787.1" /db_xref="EnsemblGenomes-Gn:BSU33222" /db_xref="EnsemblGenomes-Tr:CAX52693" /db_xref="GOA:C0H3R4" /db_xref="UniProtKB/Swiss-Prot:C0H3R4" /translation="MDGQFEQKKKQKDETYDIEHLIACFSPMIRKKLSNTSYQEREDL EQELKIKMFEKADMLLCQDVPGFWEFILYMVDENS*" /label="rsoA CDS" gene complement(3033542..3033781) /gene="rsoA" /locus_tag="BSU_33222" /old_locus_tag="BSU33222" /label="rsoA gene" downshifts complement(3033549) /Source="Nicolas_upshifts" /id="D1716" /incds=0 /nref=4 /ntot=30 /MaxReadThrough="2.45068" /MaxDrop="3.82244" /score="12.6471586" /energy="-8.2" /TU="NA" /idTUdmin="U2605" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3033777..3033795) /Source="Nicolas_upshift_promotors" /id="U2603" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=142 /SigmaFactorBS="ataaaaaggggctggagaatatcagaaagcAGTTAGCggcgc aaaaaaaggGGGAAAAGTAAGCTGTGGAcggccagtttgaacaaaaaaagaaacaaaa a" /listShort="rsoA" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(3033785..3034315) /gene="sigO" /locus_tag="BSU_33230" /old_locus_tag="BSU33230" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16306698, 18573182, 19047353, 27558998" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16306698, 18573182, 19047353, 27558998; Product type r: regulator" /codon_start=1 /transl_table=11 /product="alternative sigma factor" /protein_id="NP_391203.2" /db_xref="EnsemblGenomes-Gn:BSU33230" /db_xref="EnsemblGenomes-Tr:CAB15313" /db_xref="GOA:O34843" /db_xref="InterPro:IPR007630" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG14147" /db_xref="UniProtKB/Swiss-Prot:O34843" /translation="MKHPIVKHFLSNPQHYRLFKNVMESPNEKDARSLDELFKQFYKE IRIVKYMNSMIRIFSIDFDKRVRKNQKRYPLTVDHPEAGDRLSSETGSDAFEEFLDRQ DDLSQHVQDYQLYQAIQKLTDKQKSVLTKVYLHGATMQEIADSLGESRQNISNIHKKG LENIRKQLAAQKKGEK*" /label="sigO CDS" gene complement(3033785..3034315) /gene="sigO" /locus_tag="BSU_33230" /old_locus_tag="BSU33230" /label="sigO gene" upshifts complement(3033786) /Source="Nicolas_upshifts" /id="U2603" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=142 /SigmaFactorBS="ataaaaaggggctggagaatatcagaaagcAGTTAGCggcgc aaaaaaaggGGGAAAAGTAAGCTGTGGAcggccagtttgaacaaaaaaagaaacaaaa a" /listShort="rsoA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3033810..3033816) /Source="Nicolas_upshift_promotors" /id="U2603" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=142 /SigmaFactorBS="ataaaaaggggctggagaatatcagaaagcAGTTAGCggcgc aaaaaaaggGGGAAAAGTAAGCTGTGGAcggccagtttgaacaaaaaaagaaacaaaa a" /listShort="rsoA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3034318..3034337) /Source="Nicolas_upshift_promotors" /id="U2604" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=2005 /SigmaFactorBS="tcatttaatttagtagggaggcggttTGATGGACtatcaaag tcttttACGGTCAAAATGTAAGGAGAtaatgaagcatcccatcgtgaagcattttttg a" /listShort="sigO, rsoA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3034325) /Source="Nicolas_upshifts" /id="U2604" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=2005 /SigmaFactorBS="tcatttaatttagtagggaggcggttTGATGGACtatcaaag tcttttACGGTCAAAATGTAAGGAGAtaatgaagcatcccatcgtgaagcattttttg a" /listShort="sigO, rsoA" /GFF_Attribute="listLong" /label="upshifts" CDS 3034330..3034668 /gene="yvrJ" /locus_tag="BSU_33239" /old_locus_tag="BSU33239" /experiment="publication(s) with functional evidences, PMID:18573182, 19047353" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18573182, 19047353; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor involved in oxalate decarboxylase expression" /protein_id="YP_003097788.1" /db_xref="EnsemblGenomes-Gn:BSU33239" /db_xref="EnsemblGenomes-Tr:CAX52694" /db_xref="InterPro:IPR024419" /db_xref="UniProtKB/Swiss-Prot:C0H3R5" /translation="MTVKDFDSPSNRLPTKLNEGKQKKVNYYFPPSVFQNTLQQFTFY RFSSLTYMTAEKEGRYFPMDQVFIEEVVKQIGNLGFPALIAMYLLTRFEKKFDQLIEL MTELKDHAKK*" /label="yvrJ CDS" gene 3034330..3034668 /gene="yvrJ" /locus_tag="BSU_33239" /old_locus_tag="BSU33239" /label="yvrJ gene" promotor_-35 complement(3034352..3034359) /Source="Nicolas_upshift_promotors" /id="U2604" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=2005 /SigmaFactorBS="tcatttaatttagtagggaggcggttTGATGGACtatcaaag tcttttACGGTCAAAATGTAAGGAGAtaatgaagcatcccatcgtgaagcattttttg a" /listShort="sigO, rsoA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3034368..3034387) /Source="Nicolas_upshift_promotors" /id="U2605" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.276723276723277" /psig="0.538461538461538" /xcortree=388 /SigmaFactorBS="agtattttggaagacactaggcggaaagtagtAGTTTACttt tttttgctttcCTTCATTTAATTTAGTAGGGaggcggtttgatggactatcaaagtct t" /listShort="sigO, rsoA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3034380) /Source="Nicolas_upshifts" /id="U2605" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.276723276723277" /psig="0.538461538461538" /xcortree=388 /SigmaFactorBS="agtattttggaagacactaggcggaaagtagtAGTTTACttt tttttgctttcCTTCATTTAATTTAGTAGGGaggcggtttgatggactatcaaagtct t" /listShort="sigO, rsoA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3034402..3034408) /Source="Nicolas_upshift_promotors" /id="U2605" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.276723276723277" /psig="0.538461538461538" /xcortree=388 /SigmaFactorBS="agtattttggaagacactaggcggaaagtagtAGTTTACttt tttttgctttcCTTCATTTAATTTAGTAGGGaggcggtttgatggactatcaaagtct t" /listShort="sigO, rsoA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_no_box 3034414..3034514 /Source="Nicolas_upshift_promotors" /id="U2606" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.3996003996004" /psig="0.277722277722278" /xcortree=389 /SigmaFactorBS="tttccgcctagtgtcttccaaaatactttgcagcagtttacg ttttatcggttttcctcacttacatacatgactgcagaaaaagaagggaggtattttc c" /GFF_Attribute="listShort" /listLong="S1278, oxdC, yvrL" /label="promotor_no_box" upshifts 3034474 /Source="Nicolas_upshifts" /id="U2606" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.3996003996004" /psig="0.277722277722278" /xcortree=389 /SigmaFactorBS="tttccgcctagtgtcttccaaaatactttgcagcagtttacg ttttatcggttttcctcacttacatacatgactgcagaaaaagaagggaggtattttc c" /GFF_Attribute="listShort" /listLong="S1278, oxdC, yvrL" /label="upshifts" promotor_no_box 3034642..3034742 /Source="Nicolas_upshift_promotors" /id="U2607" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.405594405594406" /psig="0.316683316683317" /xcortree=387 /SigmaFactorBS="gaactgaaagatcatgcaaaaaaataatttttcaatcgaagt tgacttttcactggtttttttcacttaacaaaacagaagggaaaacgaaaggcctttc a" /listShort="S1278, oxdC, yvrL" /GFF_Attribute="listLong" /label="promotor_no_box" S_feature 3034702..3034788 /Source="Nicolas_S_feature" /locus_tag="new_3410379_3410465" /HighExp="T5.0H, T4.0H, T3.30H, Lbstat, T3.0H, nit, T2.0H, T2.30H, LPhT, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.317" /TUlongSig="Sig-" /TUlongPSig="0.278" /label="S1278" upshifts 3034702 /Source="Nicolas_upshifts" /id="U2607" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.405594405594406" /psig="0.316683316683317" /xcortree=387 /SigmaFactorBS="gaactgaaagatcatgcaaaaaaataatttttcaatcgaagt tgacttttcactggtttttttcacttaacaaaacagaagggaaaacgaaaggcctttc a" /listShort="S1278, oxdC, yvrL" /GFF_Attribute="listLong" /label="upshifts" CDS 3034789..3035946 /gene="oxdC" /locus_tag="BSU_33240" /old_locus_tag="BSU33240" /EC_number="4.1.1.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10960116, 14697267, 14871895, 17459326, 18573182, 19047353, 21255608, 21264418, 21782782, 26744902, 27797181" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10960116, 14697267, 14871895, 17459326, 18573182, 19047353, 21255608, 21264418, 21782782, 26744902, 27797181; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="oxalate decarboxylase" /protein_id="NP_391204.1" /db_xref="EnsemblGenomes-Gn:BSU33240" /db_xref="EnsemblGenomes-Tr:CAB15314" /db_xref="GOA:O34714" /db_xref="InterPro:IPR006045" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR017774" /db_xref="PDB:1J58" /db_xref="PDB:1L3J" /db_xref="PDB:1UW8" /db_xref="PDB:2UY8" /db_xref="PDB:2UY9" /db_xref="PDB:2UYA" /db_xref="PDB:2UYB" /db_xref="PDB:2V09" /db_xref="PDB:3S0M" /db_xref="PDB:4MET" /db_xref="PDB:5HI0" /db_xref="SubtiList:BG14148" /db_xref="UniProtKB/Swiss-Prot:O34714" /translation="MKKQNDIPQPIRGDKGATVKIPRNIERDRQNPDMLVPPETDHGT VSNMKFSFSDTHNRLEKGGYAREVTVRELPISENLASVNMRLKPGAIRELHWHKEAEW AYMIYGSARVTIVDEKGRSFIDDVGEGDLWYFPSGLPHSIQALEEGAEFLLVFDDGSF SENSTFQLTDWLAHTPKEVIAANFGVTKEEISNLPGKEKYIFENQLPGSLKDDIVEGP NGEVPYPFTYRLLEQEPIESEGGKVYIADSTNFKVSKTIASALVTVEPGAMRELHWHP NTHEWQYYISGKARMTVFASDGHARTFNYQAGDVGYVPFAMGHYVENIGDEPLVFLEI FKDDHYADVSLNQWLAMLPETFVQAHLDLGKDFTDVLSKEKHPVVKKKCSK*" /label="oxdC CDS" gene 3034789..3035946 /gene="oxdC" /locus_tag="BSU_33240" /old_locus_tag="BSU33240" /label="oxdC gene" downshifts 3035932 /Source="Nicolas_upshifts" /id="D1717" /incds=0 /nref=11 /ntot=87 /MaxReadThrough="4.83038" /MaxDrop="4.39135" /score="2.61432951" /energy="-9.4" /TU="U2607" /idTUdmin="U2607" /TUdmin="-484" /isTUend="FALSE" /label="downshifts" CDS 3036007..3036417 /gene="rsiO" /locus_tag="BSU_33250" /old_locus_tag="BSU33250" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 18573182, 19047353, 26651345" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 18573182, 19047353, 26651345; Product type f: factor" /codon_start=1 /transl_table=11 /product="acid stress-sensitive anti sigma factor" /protein_id="NP_391205.1" /db_xref="EnsemblGenomes-Gn:BSU33250" /db_xref="EnsemblGenomes-Tr:CAB15315" /db_xref="GOA:O34686" /db_xref="InterPro:IPR025912" /db_xref="SubtiList:BG14149" /db_xref="UniProtKB/Swiss-Prot:O34686" /translation="MKHQNPSKRLLRLSIKYLLAAAAVVLTYFAVIYILFSLAGTSYR SAAHVLLFAVVFLVLGLCFEPFERLMIHSFTFFKTGKRLFILLAGIVQLLFLWMTAHT TDQLISDIWLSTTEEMIVAAVFLILDKCNSALPS*" /label="rsiO CDS" gene 3036007..3036417 /gene="rsiO" /locus_tag="BSU_33250" /old_locus_tag="BSU33250" /label="rsiO gene" downshifts 3036416 /Source="Nicolas_upshifts" /id="D1718" /incds=0 /nref=1 /ntot=22 /MaxReadThrough="0.57216" /MaxDrop="3.72691" /score="-9.50136752" /energy="-7.4" /TU="NA" /idTUdmin="U2607" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3036451..3037680) /gene="yvrN" /locus_tag="BSU_33260" /old_locus_tag="BSU33260" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_391207.3" /db_xref="EnsemblGenomes-Gn:BSU33260" /db_xref="EnsemblGenomes-Tr:CAB15317" /db_xref="GOA:P46324" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR025857" /db_xref="SubtiList:BG11368" /db_xref="UniProtKB/Swiss-Prot:P46324" /translation="MLEHIRISFQSIFSHKLRSILTMLGVIIGIAAIIAIVSMLKGQS EQLKQSMIGMGNNAINVVYQPSGGEEESGGPQVSYASAPPVAEETVKAIKSDPMVKGL SLYYLSEGASVFHLTNVSYPQVYGVDDDYFDMFPIRITEGRKLTENDLNSTHQVVMIN EAVRDELFPDGEALHKSIEMNGVPFKVVGVFKEKNQQESMFEGDYANPVLYVPKKVWP LIEGFDAPTQIAVQADSSEHIQEAGVMAADLLNQGLSEAELEKAEYSVMDLQEIAQEV ESFNQSFALLLGGIASISLLVGGIGVMNIMLVSVTERTREIGIKKALGAKRRVILFQF LTEAVVLTSIGGILGVLAGFGIAKLLTVIFPMPFIVSIPAVVGALIFSMAVGIIFGLL PSIKASKLQPVDALRYE*" /label="yvrN CDS" gene complement(3036451..3037680) /gene="yvrN" /locus_tag="BSU_33260" /old_locus_tag="BSU33260" /label="yvrN gene" downshifts complement(3036468) /Source="Nicolas_upshifts" /id="D1719" /incds=0 /nref=10 /ntot=218 /MaxReadThrough="2.36812" /MaxDrop="4.29282" /score="13.74435" /energy="-11.3" /TU="NA" /idTUdmin="U2608" /TUdmin="-20" /isTUend="TRUE" /label="downshifts" CDS complement(3037673..3038362) /gene="yvrO" /locus_tag="BSU_33270" /old_locus_tag="BSU33270" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11544226, 22517742; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_391208.2" /db_xref="EnsemblGenomes-Gn:BSU33270" /db_xref="EnsemblGenomes-Tr:CAB15318" /db_xref="GOA:O34979" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG14151" /db_xref="UniProtKB/Swiss-Prot:O34979" /translation="MLTLNNISKSYKLGKEEVPILKHINLTVQAGEFLAIMGPSGSGK STLMNIIGCLDRPTSGTYTLDQIDILKGKDGALAEIRNESIGFVFQTFHLLPRLTALQ NVELPMIYNKVKKKERRQRAYEALEKVGLKDRVSYKPPKLSGGQKQRVAIARALVNQP RFILADEPTGALDTKSSEQILALFSELHREGKTIIMITHDPDVAKKADRTVFIRDGEL VLDERGDISHA*" /label="yvrO CDS" gene complement(3037673..3038362) /gene="yvrO" /locus_tag="BSU_33270" /old_locus_tag="BSU33270" /label="yvrO gene" CDS complement(3038346..3039539) /gene="yvrP" /locus_tag="BSU_33280" /old_locus_tag="BSU33280" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter membrane fusion component" /protein_id="NP_391209.1" /db_xref="EnsemblGenomes-Gn:BSU33280" /db_xref="EnsemblGenomes-Tr:CAB15319" /db_xref="GOA:O35007" /db_xref="InterPro:IPR032317" /db_xref="SubtiList:BG14152" /db_xref="UniProtKB/Swiss-Prot:O35007" /translation="MSKKKKWLIGGAICAGVLVLAGIGAGGFYFFTHMNQVAVSSEPY AESVAVYMGGDSESGQTFSGKVEPEKQQKVYIDSEKGSIKKTYVKEGDQVKKGDKLFE YEGEDHSDEVEQANLQIEMTNLQINRLQKSITETEKKLKVAGKEEKNQLQDELDQTNF DLKTSQLELKQHQKELAGLTKNKGSNVITSKHDGIVQSVNQDIADGATGDQAAGPYIQ IVSTGKYLVKSQINELLMDTIKKGSKVRVTLKTGGEGEWKGKVTSIGKLPAGAGEGEE SESFADEEMNPQSSNYPFTILLDSHKGLEVGYHVNIEVMSDNADADTIKLPSDMVIQD DGEPYVWKADENHKAVKQPVEIGETDENDMVEIKSGLTPEDYVIYPDPAVKEGKQVTV NADTE*" /label="yvrP CDS" gene complement(3038346..3039539) /gene="yvrP" /locus_tag="BSU_33280" /old_locus_tag="BSU33280" /label="yvrP gene" promotor_-10 complement(3039583..3039602) /Source="Nicolas_upshift_promotors" /id="U2608" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=2297 /SigmaFactorBS="ttttctatttgattccgtcatttcaataaaagGATTGCAAgt ctttttgaattaATAGATAATATTGGTTAGAAtgtttcgaaaatattacatagtttac a" /listShort="yvrP, yvrO, yvrN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3039596) /Source="Nicolas_upshifts" /id="U2608" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=2297 /SigmaFactorBS="ttttctatttgattccgtcatttcaataaaagGATTGCAAgt ctttttgaattaATAGATAATATTGGTTAGAAtgtttcgaaaatattacatagtttac a" /listShort="yvrP, yvrO, yvrN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3039617..3039624) /Source="Nicolas_upshift_promotors" /id="U2608" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=2297 /SigmaFactorBS="ttttctatttgattccgtcatttcaataaaagGATTGCAAgt ctttttgaattaATAGATAATATTGGTTAGAAtgtttcgaaaatattacatagtttac a" /listShort="yvrP, yvrO, yvrN" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3039710..3040519) /gene="fhuC" /locus_tag="BSU_33290" /old_locus_tag="BSU33290" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8388528, 8596459, 10913070, 15802251; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ferrichrome ABC transporter (ATP-binding protein)" /protein_id="NP_391210.1" /db_xref="EnsemblGenomes-Gn:BSU33290" /db_xref="EnsemblGenomes-Tr:CAB15335" /db_xref="GOA:P49938" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11390" /db_xref="UniProtKB/Swiss-Prot:P49938" /translation="MNSLSTEQLGIGYGDRVIVEDLNISIPKGKITTLIGPNGCGKST ILKTMSRIMRSHAGAVYLNGKAIHKMSTKDIAKDMAILPQTPEAPSGLTVHELVSYGR FPHQSGFGRLNDEDRRIIKWALEETGMAEYAERPIEALSGGQRQRVWIAMALAQGTEL LLLDEPTTYLDLAHQLEILQLLDRLNKEQGRTILMVIHDLNHAARFSHYMIALKKGTV IKEGTALEVMTPDILKQVFQIDAEIVTDPRTNKPVCLTYDLIKNEKELVTV*" /label="fhuC CDS" gene complement(3039710..3040519) /gene="fhuC" /locus_tag="BSU_33290" /old_locus_tag="BSU33290" /label="fhuC gene" downshifts complement(3039727) /Source="Nicolas_upshifts" /id="D1720" /incds=0 /nref=190 /ntot=245 /MaxReadThrough="1.31294" /MaxDrop="6.48454" /score="40.5986253" /energy="-11" /TU="NA" /idTUdmin="U2610" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 3039866..3039875 /Source="Nicolas_upshift_promotors" /id="U2609" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1247 /SigmaFactorBS="gtgtcatgacctccagagcagttccttccttgatGACCGTGC CTtttttgagcgcgATCATATAATGAGAAAAACGagctgcatggttaagatcatgaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3039888..3039907 /Source="Nicolas_upshift_promotors" /id="U2609" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1247 /SigmaFactorBS="gtgtcatgacctccagagcagttccttccttgatGACCGTGC CTtttttgagcgcgATCATATAATGAGAAAAACGagctgcatggttaagatcatgaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3039892 /Source="Nicolas_upshifts" /id="U2609" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1247 /SigmaFactorBS="gtgtcatgacctccagagcagttccttccttgatGACCGTGC CTtttttgagcgcgATCATATAATGAGAAAAACGagctgcatggttaagatcatgaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3040535..3041545) /gene="fhuG" /locus_tag="BSU_33300" /old_locus_tag="BSU33300" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8388528, 8596459, 10913070, 15802251, 15849754, 16850406, 24362930; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ferrichrome ABC transporter (permease)" /protein_id="NP_391211.1" /db_xref="EnsemblGenomes-Gn:BSU33300" /db_xref="EnsemblGenomes-Tr:CAB15336" /db_xref="GOA:P49937" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG11391" /db_xref="UniProtKB/Swiss-Prot:P49937" /translation="MKTKTNKPLIVMAVTFLLIVVVFFISLNLGVIKIAPLKTLQVFF GQGTARDELVLFEFRLPRIILSLLVGAGISVAGAILQSVSQNELAEPGILGINAGGSL AVVLFIYFFQGSASDLSFFGTFMLPFSALAGAILAAFLIYILAWKKGVTPIRLILVGI GVNAGFNALLLIFQLKMDPHDFMQAAVWISGSIWGANWNMIWAILPWIVILLLFTLYK ARYLNIMQLGDQLATGLGTAVEKERRILLLAAVTLAASCVAAAGGIAFLGLIAPHVAR RLTGPRHQTLIPVSAFIGSFLFLLADTLARNVLAPSEIPVGLVISVLGAPYFIYLLMK AN*" /label="fhuG CDS" gene complement(3040535..3041545) /gene="fhuG" /locus_tag="BSU_33300" /old_locus_tag="BSU33300" /label="fhuG gene" CDS complement(3041545..3042699) /gene="fhuB" /locus_tag="BSU_33310" /old_locus_tag="BSU33310" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8388528, 12354229, 15849754, 16850406, 24362930; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ferrichrome ABC transporter (permease)" /protein_id="NP_391212.1" /db_xref="EnsemblGenomes-Gn:BSU33310" /db_xref="EnsemblGenomes-Tr:CAB15337" /db_xref="GOA:P49936" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG11389" /db_xref="UniProtKB/Swiss-Prot:P49936" /translation="MHFHFCSKHSIKSAEKSDILKQQLIIIISNRKEVRQLSQHKNIR TASEEIQWTSRTYGAVIVLIAGLCLLCLGAFLSISLGAADIHLRTVWEAIFHYQPTKT SHQIIHDLRLPRTAAAALVGALLAVSGAIMQGMTRNPLAEPSIMGVTSGSAFAVSIAF AFFPGLSAMGLVLWSFAGAGLGASTVMGIGMFSRGGLTPVKLALAGTAVTYFFTGIST AIAIRFDVAQDISFWYAGGVAGVKWSGVQLLLIAGAVGLTLAFFIARSVTVLSLGDDL AKGLGQYTSAVKLVGMLIVVILTGAAVSIAGTIAFIGLIIPHITRFLVGVDYRWIIPC SAVLGAVLLVFADIAARLVNAPFETPVGALTSLIGVPFFFYLARRERRGL*" /label="fhuB CDS" gene complement(3041545..3042699) /gene="fhuB" /locus_tag="BSU_33310" /old_locus_tag="BSU33310" /label="fhuB gene" promotor_-10 complement(3042632..3042651) /Source="Nicolas_upshift_promotors" /id="U2610" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.58941058941059" /psig="0.994005994005994" /xcortree=2108 /SigmaFactorBS="atttttgcaaatgcattttcatttttgttcaaaacactcTAT TAAATcagctgaaaaaAGTGATATACTGAAACAGCAattgataatcattatcagtaac a" /listShort="fhuB, fhuG, fhuC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3042649) /Source="Nicolas_upshifts" /id="U2610" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.58941058941059" /psig="0.994005994005994" /xcortree=2108 /SigmaFactorBS="atttttgcaaatgcattttcatttttgttcaaaacactcTAT TAAATcagctgaaaaaAGTGATATACTGAAACAGCAattgataatcattatcagtaac a" /listShort="fhuB, fhuG, fhuC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3042663..3042670) /Source="Nicolas_upshift_promotors" /id="U2610" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.58941058941059" /psig="0.994005994005994" /xcortree=2108 /SigmaFactorBS="atttttgcaaatgcattttcatttttgttcaaaacactcTAT TAAATcagctgaaaaaAGTGATATACTGAAACAGCAattgataatcattatcagtaac a" /listShort="fhuB, fhuG, fhuC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3042711..3042718 /Source="Nicolas_upshift_promotors" /id="U2611" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.450549450549451" /psig="0.998001998001998" /xcortree=2104 /SigmaFactorBS="acaaaaatgaaaatgcatttgcaaaaataTCGTGTCAaccgg cacttgcagTGGTATAATCACAGATGATAatgattctctttttcatctatcttttaga a" /listShort="fhuD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3042733..3042752 /Source="Nicolas_upshift_promotors" /id="U2611" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.450549450549451" /psig="0.998001998001998" /xcortree=2104 /SigmaFactorBS="acaaaaatgaaaatgcatttgcaaaaataTCGTGTCAaccgg cacttgcagTGGTATAATCACAGATGATAatgattctctttttcatctatcttttaga a" /listShort="fhuD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3042742 /Source="Nicolas_upshifts" /id="U2611" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.450549450549451" /psig="0.998001998001998" /xcortree=2104 /SigmaFactorBS="acaaaaatgaaaatgcatttgcaaaaataTCGTGTCAaccgg cacttgcagTGGTATAATCACAGATGATAatgattctctttttcatctatcttttaga a" /listShort="fhuD" /GFF_Attribute="listLong" /label="upshifts" CDS 3042797..3043744 /gene="fhuD" /locus_tag="BSU_33320" /old_locus_tag="BSU33320" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8388528, 12354229, 26919525; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ferrichrome ABC transporter (ferrichrome-bindinglipoprotein)" /protein_id="NP_391213.1" /db_xref="EnsemblGenomes-Gn:BSU33320" /db_xref="EnsemblGenomes-Tr:CAB15338" /db_xref="GOA:P37580" /db_xref="InterPro:IPR002491" /db_xref="PDB:3G9Q" /db_xref="PDB:3HXP" /db_xref="SubtiList:BG10828" /db_xref="UniProtKB/Swiss-Prot:P37580" /translation="MTHIYKKLGAAFFALLLIAALAACGNNSESKGSASDSKGAETFT YKAENGNVKIPKHPKRVVVMADGYYGYFKTLGINVVGAPENVFKNPYYKGKTNGVENI GDGTSVEKVIDLNPDLIIVWTTQGADIKKLEKIAPTVAVKYDKLDNIEQLKEFAKMTG TEDKAEKWLAKWDKKVAAAKTKIKKAVGDKTISIMQTNGKDIYVFGKDFGRGGSIIYK DLGLQATKLTKEKAIDQGPGYTSISLEKLPDFAGDYIFAGPWQSGGDDGGVFESSIWK NLNAVKNGHVYKMDPIGFYFTDPISLEGQLEFITESLTK*" /label="fhuD CDS" gene 3042797..3043744 /gene="fhuD" /locus_tag="BSU_33320" /old_locus_tag="BSU33320" /label="fhuD gene" downshifts 3043720 /Source="Nicolas_upshifts" /id="D1721" /incds=0 /nref=168 /ntot=245 /MaxReadThrough="3.82329" /MaxDrop="5.73183" /score="11.0136807" /energy="-12.1" /TU="U2611" /idTUdmin="U2611" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" downshifts 3043764 /Source="Nicolas_upshifts" /id="D1722" /incds=0 /nref=1 /ntot=1 /MaxReadThrough="3.01143" /MaxDrop="4.08479" /score="11.0136807" /energy="-12.1" /TU="NA" /idTUdmin="U2611" /TUdmin=22 /isTUend="TRUE" /label="downshifts" downshifts 3043918 /Source="Nicolas_upshifts" /id="D1723" /incds=0 /nref=8 /ntot=87 /MaxReadThrough="0.219110000000001" /MaxDrop="3.67928" /score="7.53231618" /energy="-13.7" /TU="NA" /idTUdmin="U2611" /TUdmin=176 /isTUend="FALSE" /label="downshifts" CDS complement(3043979..3045388) /gene="lysP" /locus_tag="BSU_33330" /old_locus_tag="BSU33330" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 14627808, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="lysine permease" /protein_id="NP_391214.1" /db_xref="EnsemblGenomes-Gn:BSU33330" /db_xref="EnsemblGenomes-Tr:CAB15339" /db_xref="GOA:O32204" /db_xref="InterPro:IPR002293" /db_xref="SubtiList:BG14154" /db_xref="UniProtKB/Swiss-Prot:O32204" /translation="MEQTKKWGFWLLTAFVVGNMVGSGIFSLPSSLASIASPFGATSA WLLTGAGVLMIALVFGHLSIRKPELTAGPQSYARALFSDPKKGNAAGFTMVWGYWVAS WISNVAIITSLAGYLTSFFPILVDKREMFSIGGQEVTLGQLLTFAVCTILLWGTHAIL VASINGASKLNFVTTLSKVLGFVFFIVAGLFVFQTSLFGHFYFPVQGENGTSIGIGGQ VHNAAISTLWAFVGIESAVILSGRARSQRDVKRATITGLLIALSIYIIVTLITMGVLP HDKLVGSEKPFVDVLYAIVGNAGSVIMALLAILCLFGTMLGWILLGSEVPYQAAKAGD FPAFFAKTNKKGSPVIALIITNVMSQVFIFSVISRTISDAFTFLTTAATLAYLIPYLV SAIYSLKVVIKGETYDQLKGSRVRDGLIAILACAYSVFVIVTGTADLTTFILGIGLFF VGLIVYPFVSNKFQKEKQA*" /label="lysP CDS" gene complement(3043979..3045388) /gene="lysP" /locus_tag="BSU_33330" /old_locus_tag="BSU33330" /label="lysP gene" downshifts complement(3043994) /Source="Nicolas_upshifts" /id="D1724" /incds=0 /nref=168 /ntot=213 /MaxReadThrough="0.441040000000001" /MaxDrop="6.03347" /score="23.064706" /energy="-13.7" /TU="NA" /idTUdmin="U2613" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 3044806..3044810 /Source="Nicolas_upshift_promotors" /id="U2612" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.3996003996004" /psig="0.3996003996004" /xcortree=1015 /SigmaFactorBS="accgggaaataaaaatgaccgaataatgacgTTTGAaacaca aacaaaccggcAACGATAAAGAAGACAAaacctaatactttagaaagcgttgtgacaa a" /listShort="S1279, yvsG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3044828..3044844 /Source="Nicolas_upshift_promotors" /id="U2612" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.3996003996004" /psig="0.3996003996004" /xcortree=1015 /SigmaFactorBS="accgggaaataaaaatgaccgaataatgacgTTTGAaacaca aacaaaccggcAACGATAAAGAAGACAAaacctaatactttagaaagcgttgtgacaa a" /listShort="S1279, yvsG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3044835 /Source="Nicolas_upshifts" /id="U2612" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.3996003996004" /psig="0.3996003996004" /xcortree=1015 /SigmaFactorBS="accgggaaataaaaatgaccgaataatgacgTTTGAaacaca aacaaaccggcAACGATAAAGAAGACAAaacctaatactttagaaagcgttgtgacaa a" /listShort="S1279, yvsG" /GFF_Attribute="listLong" /label="upshifts" S_feature 3044842..3045809 /Source="Nicolas_S_feature" /locus_tag="new_3420519_3421486" /HighExp="S3, S4, S7, S5, S8, S6, Etha, M9-stat, T5.0H, T4.0H" /AntisenseName="NA" /AntisenseCor="7.6401427420847101E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.4" /TUlongSig="NA" /TUlongPSig="NA" /label="S1279" downshifts complement(3045490) /Source="Nicolas_upshifts" /id="D1725" /incds=0 /nref=1 /ntot=43 /MaxReadThrough="5.98281" /MaxDrop="3.61093" /score="-2.14086757" /energy="-5" /TU="U2613,U2614" /idTUdmin="U2614" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" misc_RNA complement(3045492..3045671) /gene="kswB" /locus_tag="BSU_misc_RNA_54" /product="lysine riboswitch" /experiment="publication(s) with functional evidences, PMID:22416067" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22416067; Product type n: RNA" /label="kswB RNA" gene complement(3045492..3045671) /gene="kswB" /locus_tag="BSU_misc_RNA_54" /label="kswB gene" promotor_-10 complement(3045701..3045718) /Source="Nicolas_upshift_promotors" /id="U2613" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.566433566433566" /psig="0.98101898101898" /xcortree=2399 /SigmaFactorBS="gcttggctctatccgtattttccatctgttccCTTTGACAga tcatcctttcttTGATAACCTTCTGGGAGTaactgaataattaaatcctcactctttc t" /listShort="NA, lysP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3045712) /Source="Nicolas_upshifts" /id="U2613" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.566433566433566" /psig="0.98101898101898" /xcortree=2399 /SigmaFactorBS="gcttggctctatccgtattttccatctgttccCTTTGACAga tcatcctttcttTGATAACCTTCTGGGAGTaactgaataattaaatcctcactctttc t" /listShort="NA, lysP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3045733..3045740) /Source="Nicolas_upshift_promotors" /id="U2613" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.566433566433566" /psig="0.98101898101898" /xcortree=2399 /SigmaFactorBS="gcttggctctatccgtattttccatctgttccCTTTGACAga tcatcctttcttTGATAACCTTCTGGGAGTaactgaataattaaatcctcactctttc t" /listShort="NA, lysP" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3045766 /Source="Nicolas_upshifts" /id="D1726" /incds=0 /nref=1 /ntot=10 /MaxReadThrough="3.6441" /MaxDrop="3.53891" /score="-0.527038766" /energy="-4.8" /TU="U2612" /idTUdmin="U2612" /TUdmin="-462" /isTUend="FALSE" /label="downshifts" CDS complement(3045788..3045928) /gene="sspJ" /locus_tag="BSU_33340" /old_locus_tag="BSU33340" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9852018" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9852018; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="YP_054593.1" /db_xref="EnsemblGenomes-Gn:BSU33340" /db_xref="EnsemblGenomes-Tr:CAE01467" /db_xref="GOA:Q7WY58" /db_xref="InterPro:IPR014220" /db_xref="SubtiList:BG14174" /db_xref="UniProtKB/Swiss-Prot:Q7WY58" /translation="MGFFNKDKGKRSEKEKNVIQGALEDAGSALKDDPLQEAVQKKKN NR*" /label="sspJ CDS" gene complement(3045788..3045928) /gene="sspJ" /locus_tag="BSU_33340" /old_locus_tag="BSU33340" /label="sspJ gene" downshifts complement(3045798) /Source="Nicolas_upshifts" /id="D1727" /incds=0 /nref=40 /ntot=87 /MaxReadThrough="4.06523" /MaxDrop="5.5784" /score="-1.94521013" /energy="-14.5" /TU="U2614" /idTUdmin="U2614" /TUdmin="-418" /isTUend="FALSE" /label="downshifts" upshifts complement(3045956) /Source="Nicolas_upshifts" /id="U2614" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=839 /SigmaFactorBS="gactttggacgataaaaaatatccCGCATAAtttttcaggaa aaAGGCATCTTAAAcatgtacctattttttaaaagaggtgatacgaatgggtttcttt a" /listShort="sspJ, NA" /listLong="lysP" /label="upshifts" S_feature complement(3045958..3046546) /Source="Nicolas_S_feature" /locus_tag="new_3421635_3422223_c" /HighExp="S6, S8, S7, S5, BT, G135, Diami, G180, LBGstat, S4" /AntisenseName="yvsG" /AntisenseCor="0.46604658967097301" /AntisenseRegPval="-15.2" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1280" promotor_-10 complement(3045961..3045972) /Source="Nicolas_upshift_promotors" /id="U2614" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=839 /SigmaFactorBS="gactttggacgataaaaaatatccCGCATAAtttttcaggaa aaAGGCATCTTAAAcatgtacctattttttaaaagaggtgatacgaatgggtttcttt a" /listShort="sspJ, NA" /listLong="lysP" /label="promotor_-10" promotor_-35 complement(3045986..3045992) /Source="Nicolas_upshift_promotors" /id="U2614" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=839 /SigmaFactorBS="gactttggacgataaaaaatatccCGCATAAtttttcaggaa aaAGGCATCTTAAAcatgtacctattttttaaaagaggtgatacgaatgggtttcttt a" /listShort="sspJ, NA" /listLong="lysP" /label="promotor_-35" promotor_-35 3046018..3046025 /Source="Nicolas_upshift_promotors" /id="U2615" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.82017982017982" /psig="0.997002997002997" /xcortree=2476 /SigmaFactorBS="tgaaaaattatgcgggatattttttatcgtccaaagtccTGT TGATCaaacatacattctctTGATATATTTGTAATTCAGAgattttttgcaaaagata a" /listShort="yvsG, yvgJ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3046039 /Source="Nicolas_upshifts" /id="U2615" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.82017982017982" /psig="0.997002997002997" /xcortree=2476 /SigmaFactorBS="tgaaaaattatgcgggatattttttatcgtccaaagtccTGT TGATCaaacatacattctctTGATATATTTGTAATTCAGAgattttttgcaaaagata a" /listShort="yvsG, yvgJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3046041..3046060 /Source="Nicolas_upshift_promotors" /id="U2615" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.82017982017982" /psig="0.997002997002997" /xcortree=2476 /SigmaFactorBS="tgaaaaattatgcgggatattttttatcgtccaaagtccTGT TGATCaaacatacattctctTGATATATTTGTAATTCAGAgattttttgcaaaagata a" /listShort="yvsG, yvgJ" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3046095..3046577 /gene="yvsG" /locus_tag="BSU_33350" /old_locus_tag="BSU33350" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16267290, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane hydrolase" /protein_id="NP_391215.1" /db_xref="EnsemblGenomes-Gn:BSU33350" /db_xref="EnsemblGenomes-Tr:CAB15340" /db_xref="GOA:O32205" /db_xref="InterPro:IPR007404" /db_xref="InterPro:IPR016956" /db_xref="SubtiList:BG14153" /db_xref="UniProtKB/Swiss-Prot:O32205" /translation="MTGKTHIMGGIASCTAAAYYYGFDPVLMAASGAVGALIPDICHT QSKIGRKFPILSKVVSSVFGHRTFTHSLLFMLIMFFITSTYIPDKNISAGLMIGMASH LILDAWTVNGIKLLFPSTIRVRLPLYMKTGSFSEQLVLAGLTLASCYYFYMLFHGRMF *" /label="yvsG CDS" gene 3046095..3046577 /gene="yvsG" /locus_tag="BSU_33350" /old_locus_tag="BSU33350" /label="yvsG gene" promotor_-35 3046591..3046598 /Source="Nicolas_upshift_promotors" /id="U2616" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.724275724275724" /psig="0.999000999001" /xcortree=1927 /SigmaFactorBS="gccgcatgttttaaacatgagtgctgaGACTTGTCtgaaccg gctgttTTTAGTAGGTTTTACTTAAGaagcatttcatgcagatgatcaagaaaacgtg a" /listShort="yvgJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3046612..3046631 /Source="Nicolas_upshift_promotors" /id="U2616" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.724275724275724" /psig="0.999000999001" /xcortree=1927 /SigmaFactorBS="gccgcatgttttaaacatgagtgctgaGACTTGTCtgaaccg gctgttTTTAGTAGGTTTTACTTAAGaagcatttcatgcagatgatcaagaaaacgtg a" /listShort="yvgJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3046624 /Source="Nicolas_upshifts" /id="U2616" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.724275724275724" /psig="0.999000999001" /xcortree=1927 /SigmaFactorBS="gccgcatgttttaaacatgagtgctgaGACTTGTCtgaaccg gctgttTTTAGTAGGTTTTACTTAAGaagcatttcatgcagatgatcaagaaaacgtg a" /listShort="yvgJ" /GFF_Attribute="listLong" /label="upshifts" CDS 3046677..3048530 /gene="ltaSP" /locus_tag="BSU_33360" /old_locus_tag="BSU33360" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15187182, 21255105, 23103977, 25288647" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15187182, 21255105, 23103977, 25288647; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="primase of polyglycerolphosphate lipoteichoic acid (LTA) synthesis" /protein_id="NP_391216.1" /db_xref="EnsemblGenomes-Gn:BSU33360" /db_xref="EnsemblGenomes-Tr:CAB15341" /db_xref="GOA:O32206" /db_xref="InterPro:IPR000917" /db_xref="InterPro:IPR012160" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="SubtiList:BG14092" /db_xref="UniProtKB/Swiss-Prot:O32206" /translation="MKGTFFHNQRFLCFSILFMWIKTYVIYKLGFDLQIDTLLEELML LVNPLSFILPLFGIGLFLKENKQRAFLLIANLVLTVILISNTIFYGFYIDFITIPVLF QASNMSDMGSSVKELFHPLFIALFVDLVFLLLFARKTKHPQTKAAPHTIKRYYAASCG MLLCTLALAEVQQPKLLAHSFDREMLVKSIGLFQFHIYDTISQTVNISAKAFADEDSI TAIKNYTEADYSKPDQSKFGLAKGRNVIFVTLESTQSFVLNEKVNGKEITPFMNDLIK KSYSFDHFYQQTEQGKTSDSEFIVANSLYPSLSGAVFFTKSDHQFHTMYKSLKQHDYY SAVFHANHKTFWNRDVMYDTFGIDRFFDVDDFHVTPGTSTSWGLKDKEFLEQSAKKLK SLPQPFYSSFITLTNHFPFEIDEKDQLIDEFDSSSDLLNRYVTTVRYEDEALKHFIKK LKDEGLYENSMIVFMGDHYGISEAHNEAMAEFLGKDEITPYDNVQLQRVPFIIHIPGI TDQQPETIPDAGGQVDVRPTLMHLLGVETKGDIQFGNDLLSGDRTPFAVLRNGSFITN DYVYTKNTCYSQKTGEVLEDQDACLPYKEKANEELSLSDKILNGDLLRFSE*" /label="ltaSP CDS" gene 3046677..3048530 /gene="ltaSP" /locus_tag="BSU_33360" /old_locus_tag="BSU33360" /label="ltaSP gene" downshifts 3048516 /Source="Nicolas_upshifts" /id="D1728" /incds=0 /nref=30 /ntot=171 /MaxReadThrough="1.18268" /MaxDrop="3.6959" /score="21.1397957" /energy="-10.5" /TU="NA" /idTUdmin="U2615" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3048558..3049484) /gene="yvgK" /locus_tag="BSU_33370" /old_locus_tag="BSU33370" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative molybdate binding regulator" /protein_id="NP_391217.1" /db_xref="EnsemblGenomes-Gn:BSU33370" /db_xref="EnsemblGenomes-Tr:CAB15342" /db_xref="GOA:O32207" /db_xref="InterPro:IPR009061" /db_xref="InterPro:IPR010093" /db_xref="InterPro:IPR024370" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG14093" /db_xref="UniProtKB/Swiss-Prot:O32207" /translation="MNETSSYTIEEVAGLLKVSKLTVYDLIKKGVLPAYRVGRQMRVD EEDLKQYKTNMRMSQPIAAKEAPKQVQEAEPDGRPNVMISGQDISMDILSKHLENAIQ ETPLRKYKGSLNSLIDMYQGKCDIVSLHLYDAETGQYNAPYVKRILTGEPFCLINVVL RKAGLYVQKGNPKNIQGWKDLKRADIRIINREKGSGARVLLDEQLGLLGVNPADVVGY GDIVTDHYAAASQVSSGQADAGIGAQHAAHMGSVDFIPLIDEQYDIVVLKKNEQLLKA VKEILNSEDYKANLSHLNGYETKLTGKVILET*" /label="yvgK CDS" gene complement(3048558..3049484) /gene="yvgK" /locus_tag="BSU_33370" /old_locus_tag="BSU33370" /label="yvgK gene" downshifts complement(3048570) /Source="Nicolas_upshifts" /id="D1729" /incds=0 /nref=232 /ntot=260 /MaxReadThrough="0.15268" /MaxDrop="6.72558" /score="21.9965704" /energy="-10.5" /TU="NA" /idTUdmin="U2617" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3049496..3049515) /Source="Nicolas_upshift_promotors" /id="U2617" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.712287712287712" /psig="0.997002997002997" /xcortree=2738 /SigmaFactorBS="ttagatataactaattataactgattatgtttggtttatgtg gGTTTttttacattcggcgaAAAGGTATAATAAAATAGGAgagtgatgatgatgaatg a" /listShort="yvgK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3049517) /Source="Nicolas_upshifts" /id="U2617" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.712287712287712" /psig="0.997002997002997" /xcortree=2738 /SigmaFactorBS="ttagatataactaattataactgattatgtttggtttatgtg gGTTTttttacattcggcgaAAAGGTATAATAAAATAGGAgagtgatgatgatgaatg a" /listShort="yvgK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3049531..3049534) /Source="Nicolas_upshift_promotors" /id="U2617" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.712287712287712" /psig="0.997002997002997" /xcortree=2738 /SigmaFactorBS="ttagatataactaattataactgattatgtttggtttatgtg gGTTTttttacattcggcgaAAAGGTATAATAAAATAGGAgagtgatgatgatgaatg a" /listShort="yvgK" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 3049553..3049572 /Source="Nicolas_upshift_promotors" /id="U2618" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.95104895104895" /xcortree=2395 /SigmaFactorBS="tttattataccttttcgccgaatgtaaaaaaacccacataaa ccaaacataATCAGTTATAATTAGTTATAtctaatgataaggggtgcaatcatgttta a" /listShort="yvgL, yvgM" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3049562 /Source="Nicolas_upshifts" /id="U2618" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.95104895104895" /xcortree=2395 /SigmaFactorBS="tttattataccttttcgccgaatgtaaaaaaacccacataaa ccaaacataATCAGTTATAATTAGTTATAtctaatgataaggggtgcaatcatgttta a" /listShort="yvgL, yvgM" /GFF_Attribute="listLong" /label="upshifts" CDS 3049595..3050377 /gene="modA" /locus_tag="BSU_33380" /old_locus_tag="BSU33380" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9302996; Product type lp : lipoprotein" /codon_start=1 /transl_table=11 /product="molybdate-binding lipoprotein" /protein_id="NP_391218.1" /db_xref="EnsemblGenomes-Gn:BSU33380" /db_xref="EnsemblGenomes-Tr:CAB15343" /db_xref="GOA:O32208" /db_xref="InterPro:IPR005950" /db_xref="SubtiList:BG14094" /db_xref="UniProtKB/Swiss-Prot:O32208" /translation="MFKKYSIFIAALTAFLLVAGCSSNQSSTDSEKKVTLTISAAASA QDALEEIQKNYEKDHQHITIQDNYGSSGALQKQISQGAGADLFFSAAEDKFKKLVDDG DIAKKDSTELVGNEIVLVVPKNGDSPVTSFSNLAESEKIALGTPESVPAGAYGKESLT KLSLWDKVKDKIVYGKDVRQVLSYVETGNVDAGVVYKTDALVSKKVNIVDEAKADTHS PIVYPLGIVKDTKHRKEAKEFYEYLQSDEAMKVFEKYGFTAE*" /label="modA CDS" gene 3049595..3050377 /gene="modA" /locus_tag="BSU_33380" /old_locus_tag="BSU33380" /label="modA gene" CDS 3050349..3051041 /gene="modB" /locus_tag="BSU_33390" /old_locus_tag="BSU33390" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="molybdenum transport permease" /protein_id="NP_391219.3" /db_xref="EnsemblGenomes-Gn:BSU33390" /db_xref="EnsemblGenomes-Tr:CAB15344" /db_xref="GOA:O32209" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR011867" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG14095" /db_xref="UniProtKB/Swiss-Prot:O32209" /translation="MRNMALLPSSISASEFFTPVVLSFQVAAVAGIVVIILGTLAGAW MSRASFFGKTALETCFMLPLVLPPTVVGFILIVIFGKHSFIGQAIEWIFQQPVIFTWW AAVIASAVVAFPLMYQSAKTGFADIDPDIQGAAMVDGASRWKVFIHISVPLAYPSLLT GSILSLARALGEFGATLMFAGNIPGVTQTLPTAIYVALDSGNNTLAWAWVVCIVVISF LMLFFIQQKKTH*" /label="modB CDS" gene 3050349..3051041 /gene="modB" /locus_tag="BSU_33390" /old_locus_tag="BSU33390" /label="modB gene" downshifts 3051033 /Source="Nicolas_upshifts" /id="D1730" /incds=0 /nref=40 /ntot=195 /MaxReadThrough="0.43895" /MaxDrop="4.92503" /score="19.0609965" /energy="-9.4" /TU="NA" /idTUdmin="U2618" /TUdmin=9 /isTUend="TRUE" /label="downshifts" CDS complement(3051072..3051902) /gene="pgoN" /locus_tag="BSU_33400" /old_locus_tag="BSU33400" /EC_number="1.1.1.283" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11544192, 16232966, 17114254, 19585557" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11544192, 16232966, 17114254, 19585557; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous glyoxal/methylglyoxal reductase" /protein_id="NP_391220.1" /db_xref="EnsemblGenomes-Gn:BSU33400" /db_xref="EnsemblGenomes-Tr:CAB15345" /db_xref="GOA:O32210" /db_xref="InterPro:IPR018170" /db_xref="InterPro:IPR020471" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="PDB:3D3F" /db_xref="PDB:3F7J" /db_xref="SubtiList:BG14096" /db_xref="UniProtKB/Swiss-Prot:O32210" /translation="MPTSLKDTVKLHNGVEMPWFGLGVFKVENGNEATESVKAAIKNG YRSIDTAAIYKNEEGVGIGIKESGVAREELFITSKVWNEDQGYETTLAAFEKSLERLQ LDYLDLYLIHWPGKDKYKDTWRALEKLYKDGKIRAIGVSNFQVHHLEELLKDAEIKPM VNQVEFHPRLTQKELRDYCKGQGIQLEAWSPLMQGQLLDNEVLTQIAEKHNKSVAQVI LRWDLQHGVVTIPKSIKEHRIIENADIFDFELSQEDMDKIDALNKDERVGPNPDELLF *" /label="pgoN CDS" gene complement(3051072..3051902) /gene="pgoN" /locus_tag="BSU_33400" /old_locus_tag="BSU33400" /label="pgoN gene" downshifts complement(3051078) /Source="Nicolas_upshifts" /id="D1731" /incds=0 /nref=190 /ntot=269 /MaxReadThrough="4.7445" /MaxDrop="7.9269" /score="27.8070829" /energy="-9.7" /TU="U2620" /idTUdmin="U2620" /TUdmin="-528" /isTUend="FALSE" /label="downshifts" promotor_-35 3051765..3051769 /Source="Nicolas_upshift_promotors" /id="U2619" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.971028971028971" /psig="0.001998001998002" /xcortree=43 /SigmaFactorBS="catttttgtagatcgctgctgtatcaatactGCGATagccat ttttaattgCCGCTttcactgattcagtcgcttcattaccattttctactttaaaaac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3051785..3051789 /Source="Nicolas_upshift_promotors" /id="U2619" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.971028971028971" /psig="0.001998001998002" /xcortree=43 /SigmaFactorBS="catttttgtagatcgctgctgtatcaatactGCGATagccat ttttaattgCCGCTttcactgattcagtcgcttcattaccattttctactttaaaaac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3051794 /Source="Nicolas_upshifts" /id="U2619" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.971028971028971" /psig="0.001998001998002" /xcortree=43 /SigmaFactorBS="catttttgtagatcgctgctgtatcaatactGCGATagccat ttttaattgCCGCTttcactgattcagtcgcttcattaccattttctactttaaaaac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 3051904 /Source="Nicolas_upshifts" /id="D1732" /incds=0 /nref=2 /ntot=122 /MaxReadThrough="0.95687" /MaxDrop="4.12116" /score="31.5807071" /energy="-11.6" /TU="NA" /idTUdmin="U2618" /TUdmin=880 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3051932..3051951) /Source="Nicolas_upshift_promotors" /id="U2620" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=1944 /SigmaFactorBS="tgtgaaaaaagaagcaaaaagagggtcttaagcgtatTATTG GTAtcggctgagaggaaTGTGAGATAATATAGACGCTtacatttcagtgaaagggtgg a" /listShort="yvgN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3051950) /Source="Nicolas_upshifts" /id="U2620" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=1944 /SigmaFactorBS="tgtgaaaaaagaagcaaaaagagggtcttaagcgtatTATTG GTAtcggctgagaggaaTGTGAGATAATATAGACGCTtacatttcagtgaaagggtgg a" /listShort="yvgN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3051966..3051973) /Source="Nicolas_upshift_promotors" /id="U2620" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=1944 /SigmaFactorBS="tgtgaaaaaagaagcaaaaagagggtcttaagcgtatTATTG GTAtcggctgagaggaaTGTGAGATAATATAGACGCTtacatttcagtgaaagggtgg a" /listShort="yvgN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3052058..3052064 /Source="Nicolas_upshift_promotors" /id="U2621" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=146 /SigmaFactorBS="caaatccaaacactatttttttcctattttaacaatattgAG ATTACaaatacattgagcaGGGTATGCGTGTAGTGTAAccaaatgaaaacaaaggagg a" /listShort="yvgO" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3052078 /Source="Nicolas_upshifts" /id="U2621" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=146 /SigmaFactorBS="caaatccaaacactatttttttcctattttaacaatattgAG ATTACaaatacattgagcaGGGTATGCGTGTAGTGTAAccaaatgaaaacaaaggagg a" /listShort="yvgO" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3052079..3052097 /Source="Nicolas_upshift_promotors" /id="U2621" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=146 /SigmaFactorBS="caaatccaaacactatttttttcctattttaacaatattgAG ATTACaaatacattgagcaGGGTATGCGTGTAGTGTAAccaaatgaaaacaaaggagg a" /listShort="yvgO" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3052125..3052610 /gene="yvgO" /locus_tag="BSU_33410" /old_locus_tag="BSU33410" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11988534, 22307285, 25217289; Product type f: factor" /codon_start=1 /transl_table=11 /product="exported stress induced factor" /protein_id="NP_391221.1" /db_xref="EnsemblGenomes-Gn:BSU33410" /db_xref="EnsemblGenomes-Tr:CAB15346" /db_xref="SubtiList:BG14097" /db_xref="UniProtKB/Swiss-Prot:O32211" /translation="MKRIRIPMTLALGAALTIAPLSFASAEENPAPKMSQTTTAGTTA ADVGLNVNLDVLGIANQIADAIKSAQNRDGFVKNLMESSFYASGQKYNVMVFNLSQEY EDHLNGVQFYGSAVYDGITYGIWVFEDGTFTNKGDGGWINWAFRGWFDRDGSTVAFHR P*" /label="yvgO CDS" gene 3052125..3052610 /gene="yvgO" /locus_tag="BSU_33410" /old_locus_tag="BSU33410" /label="yvgO gene" downshifts 3052609 /Source="Nicolas_upshifts" /id="D1733" /incds=0 /nref=18 /ntot=93 /MaxReadThrough="3.44281" /MaxDrop="6.83046" /score="31.5807071" /energy="-11.6" /TU="U2621" /idTUdmin="U2621" /TUdmin="-571" /isTUend="FALSE" /label="downshifts" CDS complement(3052654..3054666) /gene="nhaK" /locus_tag="BSU_33420" /old_locus_tag="BSU33420" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16021482, 16850406, 28420751" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16021482, 16850406, 28420751; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Na+/H+ antiporter" /protein_id="NP_391222.1" /db_xref="EnsemblGenomes-Gn:BSU33420" /db_xref="EnsemblGenomes-Tr:CAB15347" /db_xref="GOA:O32212" /db_xref="InterPro:IPR004705" /db_xref="InterPro:IPR006153" /db_xref="InterPro:IPR018422" /db_xref="SubtiList:BG14098" /db_xref="UniProtKB/Swiss-Prot:O32212" /translation="MDIFLVVLVLLTIIAISNIVNRFIPFIPVPLIQVALGILAASFP QGLHFELNTELFFVLFIAPLLFNDGKRTPRAELWNLRAPILLLALGLVFATVIVGGYT IHWMIPAIPLAAAFGLAAILSPTDVVAVSALSGRVKMPKGILRLLEGEGLMNDASGLV AFKFAIAAAVTGAFSLAQAAVSFVFISLGGLLCGVVISFLIIRFRLFLRRLGMQDVTM HMLIQILTPFVIYLAAEEIGVSGILAVVAGGITHAVEQDRLESTMIKLQIVSSSTWNI ILFILNGLVFVILGTQIPDVISVIFNDTAISNMKVIGYILVITFTLMLLRFLWVLFFW NGKWFFNKDQNIYKPGLRSTLLISISGVRGAVTLAGSFSIPYFLEDGTPFPERNLILF LAAGVILCTLVIATVVLPILTEKEEEDEERNKKLLTARRKLIKTALQTIKEDMNETNK TASLAVIAEYNEKMKNLRFQQYTSSNRIKKHERKVRAQGVKAEQEALMKMLERGDIPE ETANVLQERFNELEILYANPFKVGLSKTRLKRLMYWIFFGEHKKPEMSILNEAGLIRA TRVKTAKAAIEYLEKHKTDEHKEVFLSVITFYKQLIFRLEHSHHELKSSAHFENQKLE VKLKAVQAIRNEIQTLFEEREISRDISHELRQYINDVEAAMLEGGE*" /label="nhaK CDS" gene complement(3052654..3054666) /gene="nhaK" /locus_tag="BSU_33420" /old_locus_tag="BSU33420" /label="nhaK gene" downshifts complement(3052662) /Source="Nicolas_upshifts" /id="D1734" /incds=0 /nref=118 /ntot=238 /MaxReadThrough="2.66359" /MaxDrop="5.82216" /score="41.6492295" /energy="-13.2" /TU="NA" /idTUdmin="U2622" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(3054332..3054336) /Source="Nicolas_upshift_promotors" /id="U2622" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.403596403596404" /psig="0.04995004995005" /xcortree=1527 /SigmaFactorBS="tgtatttgcgactgtgattgtaggcggctacacgattcactg gatgattcctgctattCCGCTggcagcggcctttggacttgcggccattctttcaccg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3054334) /Source="Nicolas_upshifts" /id="U2622" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.403596403596404" /psig="0.04995004995005" /xcortree=1527 /SigmaFactorBS="tgtatttgcgactgtgattgtaggcggctacacgattcactg gatgattcctgctattCCGCTggcagcggcctttggacttgcggccattctttcaccg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3054667..3054818) /Source="Nicolas_S_feature" /locus_tag="new_3430344_3430495_c" /HighExp="dia5, T0.30H, T-0.40H, Salt, Diami, T1.0H, T0.0H, T1.30H, dia15, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.746, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1281" misc_feature complement(3054795..3054813) /Source="Nicolas_upshift_promotors" /id="U2623" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.341658341658342" /psig="0.746253746253746" /xcortree=1528 /SigmaFactorBS="ttctataatttgctcttctgcaaaaaagttcactgtgagcat atcatgagaaaaaataccctaaaAAGGGTACTATAAAAGAAGacaagtgtggagagaa c" /listShort="S1281, nhaK" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3054818) /Source="Nicolas_upshifts" /id="U2623" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.341658341658342" /psig="0.746253746253746" /xcortree=1528 /SigmaFactorBS="ttctataatttgctcttctgcaaaaaagttcactgtgagcat atcatgagaaaaaataccctaaaAAGGGTACTATAAAAGAAGacaagtgtggagagaa c" /listShort="S1281, nhaK" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3054921..3056636) /gene="cysI" /locus_tag="BSU_33430" /old_locus_tag="BSU33430" /EC_number="1.8.1.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11445163, 12169591, 16267287" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11445163, 12169591, 16267287; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="assimilatory sulfite reductase (hemoprotein beta-subunit)" /protein_id="NP_391223.1" /db_xref="EnsemblGenomes-Gn:BSU33430" /db_xref="EnsemblGenomes-Tr:CAB15348" /db_xref="GOA:O32213" /db_xref="InterPro:IPR005117" /db_xref="InterPro:IPR006066" /db_xref="InterPro:IPR006067" /db_xref="InterPro:IPR011786" /db_xref="InterPro:IPR036136" /db_xref="SubtiList:BG14099" /db_xref="UniProtKB/Swiss-Prot:O32213" /translation="MVTKILKAPDGSPSDVERIKKESDYLRGTLKEVMLDRISAGIPD DDNRLMKHHGSYLQDDRDLRNERQKQKLEPAYQFMLRVRMPGGVSTPEQWLVMDDLSQ KYGNGTLKLTTRETFQMHGILKWNMKKTIQTIHSALLDTIAACGDVNRNVMCASNPYQ SEIHSEVYEWSKKLSDDLLPRTRAYHEIWLDEERVAGTPEEEVEPMYGPLYLPRKFKI GIAVPPSNDIDVFSQDLGFIAIVEDGKLIGFNVAIGGGMGMTHGDTATYPQLAKVIGF CRPEQMYDVAEKTITIQRDYGNRSVRKNARFKYTVDRLGLENVKEELENRLGWSLEEA KPYHFDHNGDRYGWVEGIEDKWHFTLFVEGGRITDYDDYKLMTGLREIAKVHTGEFRL TANQNLMIANVSSDKKEEISALIEQYGLTDGKHYSALRRSSMACVALPTCGLAMAEAE RYLPTLLDKIEEIIDENGLRDQEITIRMTGCPNGCARHALGEIGFIGKAPGKYNMYLG AAFDGSRLSKMYRENIGEADILSELRILLSRYAKEREEGEHFGDFVIRAGIIKATTDG TNFHD*" /label="cysI CDS" gene complement(3054921..3056636) /gene="cysI" /locus_tag="BSU_33430" /old_locus_tag="BSU33430" /label="cysI gene" downshifts complement(3054928) /Source="Nicolas_upshifts" /id="D1735" /incds=0 /nref=211 /ntot=254 /MaxReadThrough="3.28258" /MaxDrop="6.31358" /score="23.5256972" /energy="-13.8" /TU="U2624" /idTUdmin="U2624" /TUdmin="-572" /isTUend="FALSE" /label="downshifts" CDS complement(3056662..3058479) /gene="cysJ" /locus_tag="BSU_33440" /old_locus_tag="BSU33440" /EC_number="1.8.1.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11445163, 12169591, 16267287, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11445163, 12169591, 16267287, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="assimilatory sulfite reductase (flavoprotein alpha-subunit)" /protein_id="NP_391224.1" /db_xref="EnsemblGenomes-Gn:BSU33440" /db_xref="EnsemblGenomes-Tr:CAB15349" /db_xref="GOA:O32214" /db_xref="InterPro:IPR001094" /db_xref="InterPro:IPR001433" /db_xref="InterPro:IPR001709" /db_xref="InterPro:IPR003097" /db_xref="InterPro:IPR008254" /db_xref="InterPro:IPR010199" /db_xref="InterPro:IPR017927" /db_xref="InterPro:IPR017938" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG14100" /db_xref="UniProtKB/Swiss-Prot:O32214" /translation="MQLQVMNSPFNQEQAELLNRLLPTLTESQKIWLSGYLSAQSVSA QEAAGTPAAAVSAEAPAPAVSKEVTVLYGSQTGNAQGLAENAGKQLEQSGFQVTVSSM SDFKPNQLKKVTNLLIVVSTHGEGEPPDNALSFHEFLHGRRAPKLEDLRFSVLALGDS SYEFFCQTGKEFDQRLEELGGKRISPRVDCDLDYDEPAAEWLEGVLKGLNEAGGGSAA PAPAAASQTGESSYSRTNPFRAEVLENLNLNGRGSNKETRHVELSLEGSGLTYEPGDS LGVYPENDPELVELLLKEMNWDPEEIVTLNKQGDVRPLKEALISHYEITVLTKPLLEQ AAQLTGNDELRELLAPGNEENVKAYIEGRDLLDLVRDYGPFSVSAQEFVSILRKMPAR LYSIASSLSANPDEVHLTIGAVRYDAHGRERKGVCSILCAERLQPGDTLPVYVQHNQN FKLPKDPETPIIMVGPGTGVAPFRSFMQEREETGAEGKAWMFFGDQHFVTDFLYQTEW QNWLKDGVLTKMDVAFSRDTEEKVYVQHRMLEHSAELFEWLQEGAAVYICGDEKHMAH DVHNTLLEIIEKEGNMSREEAEAYLADMQQQKRYQRDVY*" /label="cysJ CDS" gene complement(3056662..3058479) /gene="cysJ" /locus_tag="BSU_33440" /old_locus_tag="BSU33440" /label="cysJ gene" promotor_-10 complement(3058521..3058540) /Source="Nicolas_upshift_promotors" /id="U2624" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.584415584415584" /psig="0.998001998001998" /xcortree=3070 /SigmaFactorBS="ttatcattaggattcttaatagttatcatcatgtaaatatAT TTTACTtaagcctagtatTCCGGTAAAGTTCAATTAGAtgcaattttcgatcagttta t" /listShort="cysJ, cysI, S1281, nhaK" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 3058530..3058537 /Source="Nicolas_upshift_promotors" /id="U2625" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.74925074925075" /psig="0.98001998001998" /xcortree=3037 /SigmaFactorBS="atccacctcacaaagttataaactgatcgaaaattgcatcta attgaACTTTACCggaatactaggcTTAAGTAAAATATATTTACAtgatgataactat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3058540) /Source="Nicolas_upshifts" /id="U2624" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.584415584415584" /psig="0.998001998001998" /xcortree=3070 /SigmaFactorBS="ttatcattaggattcttaatagttatcatcatgtaaatatAT TTTACTtaagcctagtatTCCGGTAAAGTTCAATTAGAtgcaattttcgatcagttta t" /listShort="cysJ, cysI, S1281, nhaK" /GFF_Attribute="listLong" /label="upshifts" upshifts 3058543 /Source="Nicolas_upshifts" /id="U2625" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.74925074925075" /psig="0.98001998001998" /xcortree=3037 /SigmaFactorBS="atccacctcacaaagttataaactgatcgaaaattgcatcta attgaACTTTACCggaatactaggcTTAAGTAAAATATATTTACAtgatgataactat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3058550..3058569 /Source="Nicolas_upshift_promotors" /id="U2625" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.74925074925075" /psig="0.98001998001998" /xcortree=3037 /SigmaFactorBS="atccacctcacaaagttataaactgatcgaaaattgcatcta attgaACTTTACCggaatactaggcTTAAGTAAAATATATTTACAtgatgataactat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3058553..3058560) /Source="Nicolas_upshift_promotors" /id="U2624" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.584415584415584" /psig="0.998001998001998" /xcortree=3070 /SigmaFactorBS="ttatcattaggattcttaatagttatcatcatgtaaatatAT TTTACTtaagcctagtatTCCGGTAAAGTTCAATTAGAtgcaattttcgatcagttta t" /listShort="cysJ, cysI, S1281, nhaK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3058650..3060974) /gene="helD" /locus_tag="BSU_33450" /old_locus_tag="BSU33450" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11544244, 24520113" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11544244, 24520113; Product type f: factor" /codon_start=1 /transl_table=11 /product="transcription factor" /protein_id="NP_391225.1" /db_xref="EnsemblGenomes-Gn:BSU33450" /db_xref="EnsemblGenomes-Tr:CAB15350" /db_xref="GOA:O32215" /db_xref="InterPro:IPR000212" /db_xref="InterPro:IPR014016" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR027785" /db_xref="SubtiList:BG14101" /db_xref="UniProtKB/Swiss-Prot:O32215" /translation="MNQQDKEWKEEQSRIDEVLKELEKKERFLETSAGGLKHDIIGLR KSFWEDVKVNFDDAHEAIETMASIKQQAELLSDREHNHRRMDQQLKRIHQLKKSPYFG RIDFIENGEEQAERIYIGLASCLDEKEEHFLIYDWRAPISSLYYNYSPGKAEYEVPGE TIEGEMVLKRQFMIKNGTLKAMFNTDMTIGDEMLQEVLSHHSDTQMKNIVSTIQKEQN QIIRNEKSKILIVQGAAGSGKTSAALQRVAYLLYRHRGVIDAGQIVLFSPNFLFNSYV SSVLPELGEENMEQATFQEYIEHRLGRKFKCESPFDQLEYCLTETKGGDFPTRLAGIT WKAGLSFQQFINEYVTRLSSEGMIFKNIIFRGQKLITKEQIQSYFYSLDQNHSIPNRM EQTAKWLLSELNKLEKKERRKDWVVHEAELLDKEDYLDVYKKLQERKRFSESTFNDYQ REQQLLAAIIVKKAFKPLKQAVRLLAFLDVTQLYLQLFSGWGGKFQHEKMDAIGELTR SAFTDNKLLYEDAAPFLYMQDLIEGRKKNTKIKHLFIDEAQDYSPFQMAYMRSIFPAA SMTVLGDINQSIYAHTINGDQRMDACFEDEPAEYVRLKRTYRSTRQIVEFTKAMLQDG ADIEPFNRSGEMPLVVKTEGHESLCQKLAQEIGRLKKKGHETIAVICKTAHQCIQAHA HMSEYTDVRLIHKENQPFQKGVCVIPVYLAKGIEFDAVLVYDASEEHYHTEHDRRLLY TACTRAMHMLAVFYTGEASPFVTAVPPHLYQIAE*" /label="helD CDS" gene complement(3058650..3060974) /gene="helD" /locus_tag="BSU_33450" /old_locus_tag="BSU33450" /label="helD gene" downshifts complement(3058668) /Source="Nicolas_upshifts" /id="D1736" /incds=0 /nref=26 /ntot=168 /MaxReadThrough="1.20405" /MaxDrop="4.59044" /score="18.6044234" /energy="-8.5" /TU="NA" /idTUdmin="U2628" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 3060994..3061001 /Source="Nicolas_upshift_promotors" /id="U2626" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.888111888111888" /psig=1 /xcortree=3099 /SigmaFactorBS="atcctgctgattcatgaacggcacctccagaaaaTAGTTGAC aaacatagatgaaaTACTGTAAAATATAATTGGAtacatatattaaatatatgatgca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3061016..3061035 /Source="Nicolas_upshift_promotors" /id="U2626" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.888111888111888" /psig=1 /xcortree=3099 /SigmaFactorBS="atcctgctgattcatgaacggcacctccagaaaaTAGTTGAC aaacatagatgaaaTACTGTAAAATATAATTGGAtacatatattaaatatatgatgca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature complement(3061017..3061032) /Source="Nicolas_upshift_promotors" /id="U2627" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.276723276723277" /psig="0.398601398601399" /xcortree=685 /SigmaFactorBS="attataaattgtatttgccagtttgcatcatatatttaatat atgtatccAATTATATTTTACAGTatttcatctatgtttgtcaactattttctggagg t" /listShort="helD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3061020 /Source="Nicolas_upshifts" /id="U2626" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.888111888111888" /psig=1 /xcortree=3099 /SigmaFactorBS="atcctgctgattcatgaacggcacctccagaaaaTAGTTGAC aaacatagatgaaaTACTGTAAAATATAATTGGAtacatatattaaatatatgatgca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3061022) /Source="Nicolas_upshifts" /id="U2627" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.276723276723277" /psig="0.398601398601399" /xcortree=685 /SigmaFactorBS="attataaattgtatttgccagtttgcatcatatatttaatat atgtatccAATTATATTTTACAGTatttcatctatgtttgtcaactattttctggagg t" /listShort="helD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3061067..3061086) /Source="Nicolas_upshift_promotors" /id="U2628" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.380619380619381" /psig="0.993006993006993" /xcortree=1452 /SigmaFactorBS="ttttctgcataatataaataacccaaacCTTGATTggtattg ggtgaatgTGCTATTATAAATTGTATTTgccagtttgcatcatatatttaatatatgt a" /listShort="helD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3061076) /Source="Nicolas_upshifts" /id="U2628" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.380619380619381" /psig="0.993006993006993" /xcortree=1452 /SigmaFactorBS="ttttctgcataatataaataacccaaacCTTGATTggtattg ggtgaatgTGCTATTATAAATTGTATTTgccagtttgcatcatatatttaatatatgt a" /listShort="helD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3061102..3061108) /Source="Nicolas_upshift_promotors" /id="U2628" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.380619380619381" /psig="0.993006993006993" /xcortree=1452 /SigmaFactorBS="ttttctgcataatataaataacccaaacCTTGATTggtattg ggtgaatgTGCTATTATAAATTGTATTTgccagtttgcatcatatatttaatatatgt a" /listShort="helD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3061112..3061131) /Source="Nicolas_upshift_promotors" /id="U2629" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.854145854145854" /psig="0.854145854145854" /xcortree=1255 /SigmaFactorBS="tcttttcgcttagataattaatagcaaaaaaaccgatttCGA AGTGAAatcggtttttttcTGCATAATATAAATAACCCAaaccttgattggtattggg t" /listShort="helD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3061132) /Source="Nicolas_upshifts" /id="U2629" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.854145854145854" /psig="0.854145854145854" /xcortree=1255 /SigmaFactorBS="tcttttcgcttagataattaatagcaaaaaaaccgatttCGA AGTGAAatcggtttttttcTGCATAATATAAATAACCCAaaccttgattggtattggg t" /listShort="helD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3061145..3061153) /Source="Nicolas_upshift_promotors" /id="U2629" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.854145854145854" /psig="0.854145854145854" /xcortree=1255 /SigmaFactorBS="tcttttcgcttagataattaatagcaaaaaaaccgatttCGA AGTGAAatcggtttttttcTGCATAATATAAATAACCCAaaccttgattggtattggg t" /listShort="helD" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3061159) /Source="Nicolas_upshifts" /id="D1737" /incds=0 /nref=19 /ntot=158 /MaxReadThrough="2.30604" /MaxDrop="4.26839" /score="16.6103553" /energy="-9.2" /TU="NA" /idTUdmin="U2630" /TUdmin=17 /isTUend="TRUE" /label="downshifts" CDS complement(3061172..3061780) /gene="yvgT" /locus_tag="BSU_33460" /old_locus_tag="BSU33460" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_391226.1" /db_xref="EnsemblGenomes-Gn:BSU33460" /db_xref="EnsemblGenomes-Tr:CAB15351" /db_xref="GOA:O32216" /db_xref="InterPro:IPR005115" /db_xref="SubtiList:BG14102" /db_xref="UniProtKB/Swiss-Prot:O32216" /translation="MAWELLSVIGIIAFAVSGAIVAMEEEYDILGVYILGIVTAFGGG AIRNLLIGVPVSALWEQGAYFQIALLSITIVFLFPKLLLKHWNKWGNLSDAIGLAAFA IQGALYAVKMGHPLSAVIVAAVLTGSGGGIIRDLLAGRKPLVLKAEIYAVWAALGGLI VGLGWLGNSFGLYVLFFVLVVCRVCSYMFNWKLPNRSFRLDN*" /label="yvgT CDS" gene complement(3061172..3061780) /gene="yvgT" /locus_tag="BSU_33460" /old_locus_tag="BSU33460" /label="yvgT gene" promotor_-10 complement(3061819..3061838) /Source="Nicolas_upshift_promotors" /id="U2630" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.642357642357642" /psig=1 /xcortree=2617 /SigmaFactorBS="attccctctaaatttatctttttttctcatgaaaatgtTATT GattttacgctggagcGATTATAAAATCTAGAGGTCgtcagaaaatttaacaaacata a" /listShort="yvgT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3061836) /Source="Nicolas_upshifts" /id="U2630" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.642357642357642" /psig=1 /xcortree=2617 /SigmaFactorBS="attccctctaaatttatctttttttctcatgaaaatgtTATT GattttacgctggagcGATTATAAAATCTAGAGGTCgtcagaaaatttaacaaacata a" /listShort="yvgT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3061854..3061858) /Source="Nicolas_upshift_promotors" /id="U2630" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.642357642357642" /psig=1 /xcortree=2617 /SigmaFactorBS="attccctctaaatttatctttttttctcatgaaaatgtTATT GattttacgctggagcGATTATAAAATCTAGAGGTCgtcagaaaatttaacaaacata a" /listShort="yvgT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3061967..3062383) /gene="bdbC" /locus_tag="BSU_33470" /old_locus_tag="BSU33470" /function="16.6: Maintain" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10455116, 11872755, 15661011, 15849754, 16751195, 16850406, 17088376" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10455116, 11872755, 15661011, 15849754, 16751195, 16850406, 17088376; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thiol-disulfide oxidoreductase" /protein_id="NP_391227.1" /db_xref="EnsemblGenomes-Gn:BSU33470" /db_xref="EnsemblGenomes-Tr:CAB15352" /db_xref="GOA:O32217" /db_xref="InterPro:IPR003752" /db_xref="InterPro:IPR012187" /db_xref="InterPro:IPR023380" /db_xref="SubtiList:BG14103" /db_xref="UniProtKB/Swiss-Prot:O32217" /translation="MKNRIVFLYASWVVALIAMLGSLYFSEIRKFIPCELCWYQRILM YPLVLILGIATFQGDTRVKKYVLPMAIIGAFISIMHYLEQKVPGFSGIKPCVSGVPCS GQYINWFGFITIPFLALIAFILIIIFMCLLKGEKSE*" /label="bdbC CDS" gene complement(3061967..3062383) /gene="bdbC" /locus_tag="BSU_33470" /old_locus_tag="BSU33470" /label="bdbC gene" downshifts complement(3061977) /Source="Nicolas_upshifts" /id="D1738" /incds=0 /nref=120 /ntot=264 /MaxReadThrough="1.31968" /MaxDrop="6.21723" /score="26.5991603" /energy="-12.7" /TU="NA" /idTUdmin="U2631" /TUdmin="-9" /isTUend="TRUE" /label="downshifts" CDS complement(3062388..3063056) /gene="bdbD" /locus_tag="BSU_33480" /old_locus_tag="BSU33480" /function="16.13: Shape" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11744713, 11872755, 12637552, 15661011, 17501922, 19535335" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11744713, 11872755, 12637552, 15661011, 17501922, 19535335; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="thiol-disulfide oxidoreductase" /protein_id="NP_391228.1" /db_xref="EnsemblGenomes-Gn:BSU33480" /db_xref="EnsemblGenomes-Tr:CAB15353" /db_xref="GOA:O32218" /db_xref="InterPro:IPR012336" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="PDB:3EU3" /db_xref="PDB:3EU4" /db_xref="PDB:3GH9" /db_xref="PDB:3GHA" /db_xref="SubtiList:BG14104" /db_xref="UniProtKB/Swiss-Prot:O32218" /translation="MKKKQQSSAKFAVILTVVVVVLLAAIVIINNKTEQGNDAVSGQP SIKGQPVLGKDDAPVTVVEFGDYKCPSCKVFNSDIFPKIQKDFIDKGDVKFSFVNVMF HGKGSRLAALASEEVWKEDPDSFWDFHEKLFEKQPDTEQEWVTPGLLGDLAKSTTKIK PETLKENLDKETFASQVEKDSDLNQKMNIQATPTIYVNDKVIKNFADYDEIKETIEKE LKGK*" /label="bdbD CDS" gene complement(3062388..3063056) /gene="bdbD" /locus_tag="BSU_33480" /old_locus_tag="BSU33480" /label="bdbD gene" promotor_-10 complement(3063108..3063127) /Source="Nicolas_upshift_promotors" /id="U2631" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.414585414585415" /psig="0.998001998001998" /xcortree=2707 /SigmaFactorBS="acaaataaattgtcggagagaattcattttttcggggTTTTC TtatcagcgcttgtCTTGTTAAAATAAAGAAGTGggtcaattgcgatccgcttctttt t" /listShort="bdbD, bdbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3063123) /Source="Nicolas_upshifts" /id="U2631" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.414585414585415" /psig="0.998001998001998" /xcortree=2707 /SigmaFactorBS="acaaataaattgtcggagagaattcattttttcggggTTTTC TtatcagcgcttgtCTTGTTAAAATAAAGAAGTGggtcaattgcgatccgcttctttt t" /listShort="bdbD, bdbC" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(3063134) /Source="Nicolas_upshifts" /id="D1739" /incds=0 /nref=3 /ntot=9 /MaxReadThrough="7.34296" /MaxDrop="3.6233" /score="12.4442247" /energy="-11.3" /TU="U2632" /idTUdmin="U2633" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 complement(3063141..3063146) /Source="Nicolas_upshift_promotors" /id="U2631" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.414585414585415" /psig="0.998001998001998" /xcortree=2707 /SigmaFactorBS="acaaataaattgtcggagagaattcattttttcggggTTTTC TtatcagcgcttgtCTTGTTAAAATAAAGAAGTGggtcaattgcgatccgcttctttt t" /listShort="bdbD, bdbC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3063176..3065284) /gene="cadA" /locus_tag="BSU_33490" /old_locus_tag="BSU33490" /EC_number="3.6.3.3" /EC_number="3.6.3.5" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7721839, 8037745, 11934502, 11922674, 12644235, 12779235, 14663075, 16901659" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7721839, 8037745, 11934502, 11922674, 12644235, 12779235, 14663075, 16901659; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Cd(II), Zn(II) and Co(II) exporter (ATPase)" /protein_id="NP_391229.3" /db_xref="EnsemblGenomes-Gn:BSU33490" /db_xref="EnsemblGenomes-Tr:CAB15354" /db_xref="GOA:O32219" /db_xref="InterPro:IPR001757" /db_xref="InterPro:IPR006121" /db_xref="InterPro:IPR008250" /db_xref="InterPro:IPR017969" /db_xref="InterPro:IPR018303" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR023298" /db_xref="InterPro:IPR023299" /db_xref="InterPro:IPR027256" /db_xref="InterPro:IPR036163" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG14105" /db_xref="UniProtKB/Swiss-Prot:O32219" /translation="MRLVKQEYVLDGLDCSNCARKIENGVKGIKGINGCAVNFAASTL TVSADGKEEQWVTNKVEKKVKSIDPHVTVRQKHIKKSADDGYRNRMVNMLIRMAAAVI LGAAAYLVQSGTIEFFLFLGAYLIIGGDIIIRAVKNIIRGQVFDEHFLMALATIGAFL IQQYPEGVAVMLFYQIGELFQGAAVSRSRKSISALMDIRPDYANLKTKNGIEQVSSED VQTGDIIVVNPGESIPLDGKVVQGSAMVDTSALTGESVPRKAAEGQDVMSGFINQNGV LHIEVTKGYQESAVSKILDLVQNASSRKARTENFITKFAKYYTPAVVIIAVLLAFVPP LVLSGAALSDWVYRALIFLVISCPCALVVSIPLGFFGGIGAASKAGVLVKGSNYLEAL NQVKYAVFDKTGTLTKGSFEVTEIKPAEGFTKDRLLEAAAYAELHSQHPIAESVRKAY GKMLSSDEIESYEEISGHGIFAKVNGTEILAGNKKLMEREQIEDVPDENAGTIVHVAV DQRYAGAIIIADEIKEDAAQAVADLKSLGIKQTAMLTGDSKQTGEAVGKQLGIGEVYA ELLPQDKVAQVEALEAKLLPSEKLIFVGDGINDTPVLARADIGVAMGGLGSDAAVEAA DIVLMTDQPSKIAEAIRIAKRTRRIVWQNIGFALGVKAIFLILGAFGIATMWEAVFSD VGVTLLAVANAMRVMRLKNK*" /label="cadA CDS" gene complement(3063176..3065284) /gene="cadA" /locus_tag="BSU_33490" /old_locus_tag="BSU33490" /label="cadA gene" S_feature complement(3065276..3065377) /Source="Nicolas_S_feature" /locus_tag="new_3440953_3441054_c" /HighExp="dia5, LBGtran, LBGstat, Diami, LBGexp, Gly, Lbtran, T0.30H, M40t45, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.982, 0.999" /TUlongSig="SigB" /TUlongPSig="0.587" /label="S1282" promotor_-10 complement(3065371..3065390) /Source="Nicolas_upshift_promotors" /id="U2632" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.576423576423576" /psig="0.982017982017982" /xcortree=1542 /SigmaFactorBS="ggctatatgccggtttttgtttttCATTGACActttcttgga aaacaACATATAATAGGTGTAACTTatatatgagtatatgctcatatatataaaataa a" /listShort="S1282, copB, bdbD, bdbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3065377) /Source="Nicolas_upshifts" /id="U2632" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.576423576423576" /psig="0.982017982017982" /xcortree=1542 /SigmaFactorBS="ggctatatgccggtttttgtttttCATTGACActttcttgga aaacaACATATAATAGGTGTAACTTatatatgagtatatgctcatatatataaaataa a" /listShort="S1282, copB, bdbD, bdbC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3065406..3065413) /Source="Nicolas_upshift_promotors" /id="U2632" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.576423576423576" /psig="0.982017982017982" /xcortree=1542 /SigmaFactorBS="ggctatatgccggtttttgtttttCATTGACActttcttgga aaacaACATATAATAGGTGTAACTTatatatgagtatatgctcatatatataaaataa a" /listShort="S1282, copB, bdbD, bdbC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3065444..3067852) /gene="copA" /locus_tag="BSU_33500" /old_locus_tag="BSU33500" /EC_number="3.6.3.54" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11922674, 11934502, 12644235, 14663075, 18215122, 19378562, 19751213, 20233928, 22077885, 22531974" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11922674, 11934502, 12644235, 14663075, 18215122, 19378562, 19751213, 20233928, 22077885, 22531974; Product type t : transporter" /codon_start=1 /transl_table=11 /product="copper transporter ATPase" /protein_id="NP_391230.2" /db_xref="EnsemblGenomes-Gn:BSU33500" /db_xref="EnsemblGenomes-Tr:CAB15355" /db_xref="GOA:O32220" /db_xref="InterPro:IPR001757" /db_xref="InterPro:IPR006121" /db_xref="InterPro:IPR006122" /db_xref="InterPro:IPR008250" /db_xref="InterPro:IPR017969" /db_xref="InterPro:IPR018303" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR023298" /db_xref="InterPro:IPR023299" /db_xref="InterPro:IPR027256" /db_xref="InterPro:IPR036163" /db_xref="InterPro:IPR036412" /db_xref="PDB:1JWW" /db_xref="PDB:1KQK" /db_xref="PDB:1OPZ" /db_xref="PDB:1OQ3" /db_xref="PDB:1OQ6" /db_xref="PDB:1P6T" /db_xref="PDB:2RML" /db_xref="PDB:2VOY" /db_xref="SubtiList:BG14106" /db_xref="UniProtKB/Swiss-Prot:O32220" /translation="MSEQKEIAMQVSGMTCAACAARIEKGLKRMPGVTDANVNLATET SNVIYDPAETGTAAIQEKIEKLGYHVVTEKAEFDIEGMTCAACANRIEKRLNKIEGVA NAPVNFALETVTVEYNPKEASVSDLKEAVDKLGYKLKLKGEQDSEAAAKKKEERKQTA RLIFSAVLSFPLLWAMVSHFTFTSFIWVPDIFLNPWMQFALATPVQFLIGWPFYVGAY KALRNKSANMDVLVALGTTAAYAYSLYLTFQSIGSHGHTDGLYYETSAILLTLILLGK LFETKAKGRSSDAIKKLMKLQAKTATVVRDGQEQIIPIDEVLVNDIVYVKPGERIPVD GEVVEGRSAVDESMITGESLPVDKNPGDSVTGSTVNANGFLKIKAVNVGKDTALSHII KIVEEAQGSKAPIQRLADQISGIFVPIVLGIAVLTFLIWYLWAAPGDFAEAISKFIAV LVIACPCALGLATPTSIMAGSGRAAEFGILFKGGEHLEKTHRLDTIVLDKTGTVTNGK PRLTDAIPFGRFEEKDLLQFAAAAETGSEHPLGEAIIAGVKDKGLEIPKLTRFEAKVG AGILAEAGGKSILVGTRKLMESEQVEHGALLAQMEELEAEGKTVMLVSIDGEAAGLVA VADTIKDTSRKAVARLKELGLDVIMMTGDNRRTAEAIAKEAGIANIIAEVLPEQKAAE IARLQKEGRQTAMVGDGINDAPALATADIGMAIGTGTDIAMETADITLIRGDLNSIAD AIRMSRLTMKNIKQNLFWALGYNSLGIPIAALGFLAPWIAGAAMAFSSVSVVLNALRL QKVK*" /label="copA CDS" gene complement(3065444..3067852) /gene="copA" /locus_tag="BSU_33500" /old_locus_tag="BSU33500" /label="copA gene" downshifts complement(3065466) /Source="Nicolas_upshifts" /id="D1740" /incds=0 /nref=15 /ntot=68 /MaxReadThrough="5.02116" /MaxDrop="3.63756" /score="26.9828242" /energy="-7.9" /TU="U2633" /idTUdmin="U2635" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(3065532) /Source="Nicolas_upshifts" /id="D1741" /incds=1 /nref=52 /ntot=227 /MaxReadThrough="5.93949" /MaxDrop="4.28993" /score="26.9828242" /energy="-7.9" /TU="U2633,U2635" /idTUdmin="U2635" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" S_feature complement(3067853..3067935) /Source="Nicolas_S_feature" /locus_tag="new_3443530_3443612_c" /HighExp="Diami, dia5, dia15, Gly, T0.30H, Heat, T1.0H, T1.30H, T0.0H, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="0.999, 0.587" /TUlongSig="NA" /TUlongPSig="NA" /label="S1283" CDS complement(3067936..3068145) /gene="copZ" /locus_tag="BSU_33510" /old_locus_tag="BSU33510" /function="16.1: Circulate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11934502, 12238948, 12590580, 14621987, 14663075, 15212800, 18419582, 27197762, 28078344" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11934502, 12238948, 12590580, 14621987, 14663075, 15212800, 18419582, 27197762, 28078344; Product type f: factor" /codon_start=1 /transl_table=11 /product="copper insertion chaperone and transporter component" /protein_id="NP_391231.1" /db_xref="EnsemblGenomes-Gn:BSU33510" /db_xref="EnsemblGenomes-Tr:CAB15356" /db_xref="GOA:O32221" /db_xref="InterPro:IPR000428" /db_xref="InterPro:IPR006121" /db_xref="InterPro:IPR006122" /db_xref="InterPro:IPR017969" /db_xref="InterPro:IPR036163" /db_xref="PDB:1K0V" /db_xref="PDB:1P8G" /db_xref="PDB:2QIF" /db_xref="PDB:3I9Z" /db_xref="SubtiList:BG14107" /db_xref="UniProtKB/Swiss-Prot:O32221" /translation="MEQKTLQVEGMSCQHCVKAVETSVGELDGVSAVHVNLEAGKVDV SFDADKVSVKDIADAIEDQGYDVAK*" /label="copZ CDS" gene complement(3067936..3068145) /gene="copZ" /locus_tag="BSU_33510" /old_locus_tag="BSU33510" /label="copZ gene" promotor_-10 complement(3068169..3068188) /Source="Nicolas_upshift_promotors" /id="U2633" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.74925074925075" /psig="0.999000999001" /xcortree=1766 /SigmaFactorBS="tggacgtatttaaaaagttcacaaaatcataaagcgtttttt aTTGTAATaccctacgggggTATGGTAGGATGAAAATAGAaagaataaacaggaggaa t" /listShort="copZ, S1283, copA, S1282, copB" /listLong="bdbD, bdbC" /label="promotor_-10" upshifts complement(3068190) /Source="Nicolas_upshifts" /id="U2633" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.74925074925075" /psig="0.999000999001" /xcortree=1766 /SigmaFactorBS="tggacgtatttaaaaagttcacaaaatcataaagcgtttttt aTTGTAATaccctacgggggTATGGTAGGATGAAAATAGAaagaataaacaggaggaa t" /listShort="copZ, S1283, copA, S1282, copB" /listLong="bdbD, bdbC" /label="upshifts" promotor_-35 complement(3068201..3068207) /Source="Nicolas_upshift_promotors" /id="U2633" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.74925074925075" /psig="0.999000999001" /xcortree=1766 /SigmaFactorBS="tggacgtatttaaaaagttcacaaaatcataaagcgtttttt aTTGTAATaccctacgggggTATGGTAGGATGAAAATAGAaagaataaacaggaggaa t" /listShort="copZ, S1283, copA, S1282, copB" /listLong="bdbD, bdbC" /label="promotor_-35" CDS complement(3068219..3068524) /gene="csoR" /locus_tag="BSU_33520" /old_locus_tag="BSU33520" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17143269, 18048925, 22904286, 24831014, 25209494" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17143269, 18048925, 22904286, 24831014, 25209494; Product type r: regulator" /codon_start=1 /transl_table=11 /product="repressor of copper utilisation proteins-Cu(I)" /protein_id="NP_391232.1" /db_xref="EnsemblGenomes-Gn:BSU33520" /db_xref="EnsemblGenomes-Tr:CAB15357" /db_xref="GOA:O32222" /db_xref="InterPro:IPR003735" /db_xref="SubtiList:BG14108" /db_xref="UniProtKB/Swiss-Prot:O32222" /translation="MEKHNEHKTLNHKSSKEKDQITNRLKRIEGQVRGIQNMVENDRY CVDILVQISAVQAAMKNVALHLLEDHAHHCVADAIKSGDGEQAISELLDVFKKFTKS* " /label="csoR CDS" gene complement(3068219..3068524) /gene="csoR" /locus_tag="BSU_33520" /old_locus_tag="BSU33520" /label="csoR gene" misc_feature 3068488..3068507 /Source="Nicolas_upshift_promotors" /id="U2634" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.877122877122877" /psig="0.986013986013986" /xcortree=2475 /SigmaFactorBS="tcaatccgcttaagccggtttgtaatctgatccttttctttc gagctttTATGGTTTAATGTTTTATGTtcgttatgcttttccatgcgtacacctctgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3068499 /Source="Nicolas_upshifts" /id="U2634" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.877122877122877" /psig="0.986013986013986" /xcortree=2475 /SigmaFactorBS="tcaatccgcttaagccggtttgtaatctgatccttttctttc gagctttTATGGTTTAATGTTTTATGTtcgttatgcttttccatgcgtacacctctgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3068538..3068557) /Source="Nicolas_upshift_promotors" /id="U2635" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.587412587412587" /psig="0.587412587412587" /xcortree=130 /SigmaFactorBS="ggtaaaacctaactgattcattttttgcgtcggcatgcttag acaacCGTTTGGacaatcagtataaTGGGAATTAATATCATTAAAcagaggtgtacgc a" /listShort="csoR, copZ, S1283, copA" /listLong="S1282, copB, bdbD, bdbC" /label="promotor_-10" upshifts complement(3068564) /Source="Nicolas_upshifts" /id="U2635" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.587412587412587" /psig="0.587412587412587" /xcortree=130 /SigmaFactorBS="ggtaaaacctaactgattcattttttgcgtcggcatgcttag acaacCGTTTGGacaatcagtataaTGGGAATTAATATCATTAAAcagaggtgtacgc a" /listShort="csoR, copZ, S1283, copA" /listLong="S1282, copB, bdbD, bdbC" /label="upshifts" promotor_-35 complement(3068571..3068577) /Source="Nicolas_upshift_promotors" /id="U2635" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.587412587412587" /psig="0.587412587412587" /xcortree=130 /SigmaFactorBS="ggtaaaacctaactgattcattttttgcgtcggcatgcttag acaacCGTTTGGacaatcagtataaTGGGAATTAATATCATTAAAcagaggtgtacgc a" /listShort="csoR, copZ, S1283, copA" /listLong="S1282, copB, bdbD, bdbC" /label="promotor_-35" promotor_-35 3068616..3068622 /Source="Nicolas_upshift_promotors" /id="U2636" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.952047952047952" /psig="0.952047952047952" /xcortree=133 /SigmaFactorBS="aagcatgccgacgcaaaaaatgaatcagttaGGTTTTAccat ttgatcaggaGGGTATATACTTCTGTTGAtaacgcttttaaaggggagaagaaaagtg g" /listShort="yvaA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3068637..3068655 /Source="Nicolas_upshift_promotors" /id="U2636" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.952047952047952" /psig="0.952047952047952" /xcortree=133 /SigmaFactorBS="aagcatgccgacgcaaaaaatgaatcagttaGGTTTTAccat ttgatcaggaGGGTATATACTTCTGTTGAtaacgcttttaaaggggagaagaaaagtg g" /listShort="yvaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3068645 /Source="Nicolas_upshifts" /id="U2636" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.952047952047952" /psig="0.952047952047952" /xcortree=133 /SigmaFactorBS="aagcatgccgacgcaaaaaatgaatcagttaGGTTTTAccat ttgatcaggaGGGTATATACTTCTGTTGAtaacgcttttaaaggggagaagaaaagtg g" /listShort="yvaA" /GFF_Attribute="listLong" /label="upshifts" CDS 3068652..3069728 /gene="iolW" /locus_tag="BSU_33530" /old_locus_tag="BSU33530" /EC_number="1.1.1.371" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15937154, 20133360, 28693424" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15937154, 20133360, 28693424; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="scyllo-inositol 2-dehydrogenase (NADP(+)-dependent)" /protein_id="NP_391233.1" /db_xref="EnsemblGenomes-Gn:BSU33530" /db_xref="EnsemblGenomes-Tr:CAB15358" /db_xref="GOA:O32223" /db_xref="InterPro:IPR000683" /db_xref="InterPro:IPR004104" /db_xref="InterPro:IPR036291" /db_xref="PDB:3GDO" /db_xref="PDB:3GFG" /db_xref="SubtiList:BG14057" /db_xref="UniProtKB/Swiss-Prot:O32223" /translation="MITLLKGRRKVDTIKVGILGYGLSGSVFHGPLLDVLDEYQISKI MTSRTEEVKRDFPDAEVVHELEEITNDPAIELVIVTTPSGLHYEHTMACIQAGKHVVM EKPMTATAEEGETLKRAADEKGVLLSVYHNRRWDNDFLTIKKLISEGSLEDINTYQVS YNRYRPEVQARWREKEGTATGTLYDLGSHIIDQTLHLFGMPKAVTANVMAQRENAETV DYFHLTLDYGKLQAILYGGSIVPANGPRYQIHGKDSSFIKYGIDGQEDALRAGRKPED DSWGADVPEFYGKLTTIRGSDKKTETIPSVNGSYLTYYRKIAESIREGAALPVTAEEG INVIRIIEAAMESSKEKRTIMLEH*" /label="iolW CDS" gene 3068652..3069728 /gene="iolW" /locus_tag="BSU_33530" /old_locus_tag="BSU33530" /label="iolW gene" downshifts 3069715 /Source="Nicolas_upshifts" /id="D1742" /incds=0 /nref=155 /ntot=248 /MaxReadThrough="2.17322" /MaxDrop="6.48885" /score="-5.36701412" /energy="-19.4" /TU="NA" /idTUdmin="U2636" /TUdmin="-9" /isTUend="TRUE" /label="downshifts" CDS complement(3069765..3070400) /gene="azoRB" /locus_tag="BSU_33540" /old_locus_tag="BSU33540" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:17284825, 17725564, 18208493" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17284825, 17725564, 18208493; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADH:dichloroindophenol oxidoreductase (2-methylhydroquinone resistance)" /protein_id="NP_391234.1" /db_xref="EnsemblGenomes-Gn:BSU33540" /db_xref="EnsemblGenomes-Tr:CAB15359" /db_xref="GOA:O32224" /db_xref="InterPro:IPR003680" /db_xref="InterPro:IPR023048" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG14058" /db_xref="UniProtKB/Swiss-Prot:O32224" /translation="MAKVLYITAHPHDEATSYSMATGKAFIESYKEANPNDEVVHIDL YKENIPHIDADVFSGWGKLQSGTGFEELSESEKAKVGRLGELSDQFASADKYVFVTPL WNFSFPPVMKAYLDSVAVAGKSFKYTEQGPVGLLTDKKAIHIQARGGYYSEGPAAEME MGHRYIGIMMNFFGVPSFDGIFVEGHNAEPDKAQQIKEDAIARAKEAGKTF*" /label="azoRB CDS" gene complement(3069765..3070400) /gene="azoRB" /locus_tag="BSU_33540" /old_locus_tag="BSU33540" /label="azoRB gene" downshifts complement(3069778) /Source="Nicolas_upshifts" /id="D1743" /incds=0 /nref=211 /ntot=263 /MaxReadThrough="1.58189" /MaxDrop="6.89477" /score="31.0885268" /energy="-15.4" /TU="NA" /idTUdmin="U2637" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3070401..3070498) /Source="Nicolas_S_feature" /locus_tag="new_3446078_3446175_c" /HighExp="Heat, UNK1, G/S, Salt, HiTm, GM-0.1, MG 25, SMM, Etha, Glucon" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1284" promotor_-10 complement(3070478..3070497) /Source="Nicolas_upshift_promotors" /id="U2637" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.431568431568432" /psig=1 /xcortree=3022 /SigmaFactorBS="ctgtttgggaaagttaaataatctttaattcgagatgttttA CTTGAAagtaaatttctttGTCTCTATAATAAAGTCTAAgagagacagaataatcatt a" /listShort="S1284, yvaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3070498) /Source="Nicolas_upshifts" /id="U2637" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.431568431568432" /psig=1 /xcortree=3022 /SigmaFactorBS="ctgtttgggaaagttaaataatctttaattcgagatgttttA CTTGAAagtaaatttctttGTCTCTATAATAAAGTCTAAgagagacagaataatcatt a" /listShort="S1284, yvaB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3070511..3070517) /Source="Nicolas_upshift_promotors" /id="U2637" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.431568431568432" /psig=1 /xcortree=3022 /SigmaFactorBS="ctgtttgggaaagttaaataatctttaattcgagatgttttA CTTGAAagtaaatttctttGTCTCTATAATAAAGTCTAAgagagacagaataatcatt a" /listShort="S1284, yvaB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3070560..3072455) /gene="yvaC" /locus_tag="BSU_33550" /old_locus_tag="BSU33550" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12107147, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391235.1" /db_xref="EnsemblGenomes-Gn:BSU33550" /db_xref="EnsemblGenomes-Tr:CAB15360" /db_xref="GOA:O32225" /db_xref="SubtiList:BG14059" /db_xref="UniProtKB/Swiss-Prot:O32225" /translation="MNKTAANNQRIMPIVKDAFRIHANPFPWKKAIGSGFASGFPVLV GALAGHTDYGLIASIGGFVYLYAGGESYKKRALKLLLVSIGIALSFGLGTLLSGMLWM MAAVLGLIGAAAMFIFSALGIQGPAPMFFVLAFLVSSGLPADPSQALFRAGLTFLGGI FAMGIALIGWLWNKHGPEGAVLQKTYHQLAACLSAVGTPGFHNAQHQTVLMLRTARQT VLGKGNRRKKSRHDERFFRLLEKADDIFIAIIHFSAETPDRETAQIEKALRQTGDMLA NARVFNTFQINENESEPRRKLFEEINEVLYIASGRFDKQLDGEPSRLPSSFYFLRNAF DWKSPVLIRALKYGIVLFAADMFALAFGFARSYWIPLSAAAVMLGTTVVFTLHRAIQR SAGTVIGVILAGAILFFKPGGVYIAFCIAALQCLLEMLIVRNYALAVPFLTANALVIT ESMHGGAGAGYFMIARLTDVAVGSVIGLLGTMLLWRRFSTKRLPELVRNVIRLEGQFM EKLLTGQIADEHKLRVSLVRLRDAYDKALGEFPHANADALWPAISGAQHLGYYLLSAQ AHRRPSAPFSDEEINQLRAFFEQAEQSFIMKRMPADIQVPHVPHYPRISKELSALYSG LRTAFEK*" /label="yvaC CDS" gene complement(3070560..3072455) /gene="yvaC" /locus_tag="BSU_33550" /old_locus_tag="BSU33550" /label="yvaC gene" promotor_-10 complement(3072506..3072517) /Source="Nicolas_upshift_promotors" /id="U2638" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=869 /SigmaFactorBS="tctctgtttttttatcgtgcgcaccaatTGAGAAGctaaccg cgtttttGGGCATACTAAAgcgaagaaactggaaaagttctacacattcattgaaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3072506) /Source="Nicolas_upshifts" /id="U2638" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=869 /SigmaFactorBS="tctctgtttttttatcgtgcgcaccaatTGAGAAGctaaccg cgtttttGGGCATACTAAAgcgaagaaactggaaaagttctacacattcattgaaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3072532..3072538) /Source="Nicolas_upshift_promotors" /id="U2638" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=869 /SigmaFactorBS="tctctgtttttttatcgtgcgcaccaatTGAGAAGctaaccg cgtttttGGGCATACTAAAgcgaagaaactggaaaagttctacacattcattgaaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3072605) /Source="Nicolas_upshifts" /id="D1744" /incds=0 /nref=20 /ntot=155 /MaxReadThrough="2.49984" /MaxDrop="4.21522" /score="11.4033831" /energy="-8" /TU="NA" /idTUdmin="U2639" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" CDS complement(3072618..3073019) /gene="yvaD" /locus_tag="BSU_33560" /old_locus_tag="BSU33560" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391236.1" /db_xref="EnsemblGenomes-Gn:BSU33560" /db_xref="EnsemblGenomes-Tr:CAB15361" /db_xref="GOA:O32226" /db_xref="InterPro:IPR020348" /db_xref="SubtiList:BG14060" /db_xref="UniProtKB/Swiss-Prot:O32226" /translation="MRYMKLFFLVTDIGFILYWLSAGFSLIPESWAFKHHDHPFMIAW NWSFFPLDILISVTGLYSLYLQRVNRADWKLMALISLVLTCCSGLQALSFWTFSSDFD LVWWLFNGYLLIYPLFFIHLLLKEGRRTKQS*" /label="yvaD CDS" gene complement(3072618..3073019) /gene="yvaD" /locus_tag="BSU_33560" /old_locus_tag="BSU33560" /label="yvaD gene" CDS complement(3073016..3073375) /gene="yvaE" /locus_tag="BSU_33570" /old_locus_tag="BSU33570" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11948170, 15849754, 16850406, 19549332; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative metabolite-efflux transporter" /protein_id="NP_391237.1" /db_xref="EnsemblGenomes-Gn:BSU33570" /db_xref="EnsemblGenomes-Tr:CAB15362" /db_xref="GOA:O32227" /db_xref="InterPro:IPR000390" /db_xref="SubtiList:BG14061" /db_xref="UniProtKB/Swiss-Prot:O32227" /translation="MNWVFLCLAILFEVAGTVSMKLSSGFTKLIPSLLLIFFYGGSLF FLTLTLKSIDVSVAYAVWSGMGIVLITVVGFLFFQEHVSVMKVISIGLIIAGVVSLNL IEHVAVSEPVHKSGQYK*" /label="yvaE CDS" gene complement(3073016..3073375) /gene="yvaE" /locus_tag="BSU_33570" /old_locus_tag="BSU33570" /label="yvaE gene" CDS complement(3073372..3073944) /gene="yvaF" /locus_tag="BSU_33580" /old_locus_tag="BSU33580" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_391238.1" /db_xref="EnsemblGenomes-Gn:BSU33580" /db_xref="EnsemblGenomes-Tr:CAB15363" /db_xref="GOA:O32228" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG14062" /db_xref="UniProtKB/Swiss-Prot:O32228" /translation="MDKRILAETFRLIKQKGFSFTMNDLAAALGTSKRTLYAYYSSKD QLVEAVVEQFIAEMKQIERDIYENESLNVLEKVKQMLISLPQGMELLNMGLLNELKKY HYDAWLTLDAFIKEEWAIVLALLNECKQQKRIRNINPDLFVHMYIGSINQVYDPEYPL KHQFTTGEVLESIVDVLFNGITADEEADAT*" /label="yvaF CDS" gene complement(3073372..3073944) /gene="yvaF" /locus_tag="BSU_33580" /old_locus_tag="BSU33580" /label="yvaF gene" promotor_-10 complement(3073982..3074001) /Source="Nicolas_upshift_promotors" /id="U2639" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=2445 /SigmaFactorBS="ccaataggagaggtttttttatataTTGTTGATttccataaa tttcTGCCGTATAATATTGGTACCgaaatagttttcttggtaccgaaagcgggggatt a" /listShort="yvaF, yvaE, yvaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3073987) /Source="Nicolas_upshifts" /id="U2639" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=2445 /SigmaFactorBS="ccaataggagaggtttttttatataTTGTTGATttccataaa tttcTGCCGTATAATATTGGTACCgaaatagttttcttggtaccgaaagcgggggatt a" /listShort="yvaF, yvaE, yvaD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3074015..3074022) /Source="Nicolas_upshift_promotors" /id="U2639" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=2445 /SigmaFactorBS="ccaataggagaggtttttttatataTTGTTGATttccataaa tttcTGCCGTATAATATTGGTACCgaaatagttttcttggtaccgaaagcgggggatt a" /listShort="yvaF, yvaE, yvaD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3074055..3074849) /gene="yvaG" /locus_tag="BSU_33590" /old_locus_tag="BSU33590" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391239.1" /db_xref="EnsemblGenomes-Gn:BSU33590" /db_xref="EnsemblGenomes-Tr:CAB15364" /db_xref="GOA:O32229" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG14063" /db_xref="UniProtKB/Swiss-Prot:O32229" /translation="MKLNLQGKTALVTGSTSGIGKAIASSLAEEGAAVIINGRREEKV NQTIDELKTQHAEAVLYPAAFDLGTEEGCNELFQAYPEVDILVNNLGIFEPAEYFDIP DDEWFRFFEVNIMSGVRLTRRYLHNMIEKKEGRVIFIASEAAIMPSQEMAHYSATKTM QLSISRSLAELATGTNVTVNTVMPGSTLTEGVETMLNSLYPGENLTVQEAEARFMKEN RPTSIIQRLIRPEEIAHFVTFLSSPLSSAINGAALRADGGLVRSVF*" /label="yvaG CDS" gene complement(3074055..3074849) /gene="yvaG" /locus_tag="BSU_33590" /old_locus_tag="BSU33590" /label="yvaG gene" promotor_-10 complement(3074870..3074888) /Source="Nicolas_upshift_promotors" /id="U2640" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.98101898101898" /psig="0.98101898101898" /xcortree=725 /SigmaFactorBS="atcccagctgtttcatactgattgcagagcagaTGTTTCAcc aatcagatttctGTCAATAAATAAGAGGAATcaaaaacggagggatgaataatgaagc t" /listShort="yvaG, yvaF, yvaE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3074882) /Source="Nicolas_upshifts" /id="U2640" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.98101898101898" /psig="0.98101898101898" /xcortree=725 /SigmaFactorBS="atcccagctgtttcatactgattgcagagcagaTGTTTCAcc aatcagatttctGTCAATAAATAAGAGGAATcaaaaacggagggatgaataatgaagc t" /listShort="yvaG, yvaF, yvaE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3074903..3074909) /Source="Nicolas_upshift_promotors" /id="U2640" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.98101898101898" /psig="0.98101898101898" /xcortree=725 /SigmaFactorBS="atcccagctgtttcatactgattgcagagcagaTGTTTCAcc aatcagatttctGTCAATAAATAAGAGGAATcaaaaacggagggatgaataatgaagc t" /listShort="yvaG, yvaF, yvaE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3074915..3074934) /Source="Nicolas_upshift_promotors" /id="U2641" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.866133866133866" /psig="0.94005994005994" /xcortree=2724 /SigmaFactorBS="tttctccaaaccacaggcaccaaaaagtgcgTACTTCCAttt caatcccagcTGTTTCATACTGATTGCAGAgcagatgtttcaccaatcagatttctgt c" /listShort="yvaG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3074926) /Source="Nicolas_upshifts" /id="U2641" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.866133866133866" /psig="0.94005994005994" /xcortree=2724 /SigmaFactorBS="tttctccaaaccacaggcaccaaaaagtgcgTACTTCCAttt caatcccagcTGTTTCATACTGATTGCAGAgcagatgtttcaccaatcagatttctgt c" /listShort="yvaG" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3074928..3074993) /Source="Nicolas_S_feature" /locus_tag="new_3450605_3450670_c" /HighExp="H2O2, Heat, Diami, G180, Paraq, dia15, Oxctl, BMM, G135, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.47, 0.997" /TUlongSig="SigA, SigA" /TUlongPSig="0.996, 1" /label="S1285" promotor_-35 complement(3074948..3074955) /Source="Nicolas_upshift_promotors" /id="U2641" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.866133866133866" /psig="0.94005994005994" /xcortree=2724 /SigmaFactorBS="tttctccaaaccacaggcaccaaaaagtgcgTACTTCCAttt caatcccagcTGTTTCATACTGATTGCAGAgcagatgtttcaccaatcagatttctgt c" /listShort="yvaG" /GFF_Attribute="listLong" /label="promotor_-35" misc_RNA complement(3075035..3075394) /gene="ssrA" /locus_tag="BSU_misc_RNA_55" /product="transfer-messenger RNA (tmRNA, 10Sa RNA)" /experiment="publication(s) with functional evidences, PMID:11395451, 11918677, 14766921, 17369301, 18673456" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11395451, 11918677, 14766921, 17369301, 18673456" /label="ssrA RNA" gene complement(3075035..3075394) /gene="ssrA" /locus_tag="BSU_misc_RNA_55" /label="ssrA gene" downshifts complement(3075038) /Source="Nicolas_upshifts" /id="D1745" /incds=0 /nref=260 /ntot=272 /MaxReadThrough="4.32959" /MaxDrop="9.81359" /score="26.7868133" /energy="-15.8" /TU="U2642,U2644" /idTUdmin="U2643" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3075378..3075386) /Source="Nicolas_upshift_promotors" /id="U2642" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.46953046953047" /psig="0.46953046953047" /xcortree=677 /SigmaFactorBS="atagccagtttgagtgagagcttgatattttctcccgtattt CCCTTAtaccaaggggacgtTACGGATTCgacagggatggatcgagcttgagctgcga g" /listShort="ssrA, S1285, yvaG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3075388) /Source="Nicolas_upshifts" /id="U2642" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.46953046953047" /psig="0.46953046953047" /xcortree=677 /SigmaFactorBS="atagccagtttgagtgagagcttgatattttctcccgtattt CCCTTAtaccaaggggacgtTACGGATTCgacagggatggatcgagcttgagctgcga g" /listShort="ssrA, S1285, yvaG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3075401..3075406) /Source="Nicolas_upshift_promotors" /id="U2642" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.46953046953047" /psig="0.46953046953047" /xcortree=677 /SigmaFactorBS="atagccagtttgagtgagagcttgatattttctcccgtattt CCCTTAtaccaaggggacgtTACGGATTCgacagggatggatcgagcttgagctgcga g" /listShort="ssrA, S1285, yvaG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3075446..3075465) /Source="Nicolas_upshift_promotors" /id="U2643" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.563436563436563" /psig="0.999000999001" /xcortree=1661 /SigmaFactorBS="tcacgacgccattcatttgaaggatttgacaaTTGAAaagag ccgtgatCATGTTATAATAAGACTATAgccagtttgagtgagagcttgatattttctc c" /listShort="ssrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3075454) /Source="Nicolas_upshifts" /id="U2643" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.563436563436563" /psig="0.999000999001" /xcortree=1661 /SigmaFactorBS="tcacgacgccattcatttgaaggatttgacaaTTGAAaagag ccgtgatCATGTTATAATAAGACTATAgccagtttgagtgagagcttgatattttctc c" /listShort="ssrA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3075456..3075520) /Source="Nicolas_S_feature" /locus_tag="new_3451133_3451197_c" /HighExp="Etha, C90, dia5, dia15, Diami, T0.0H, T-0.40H, T-1.40H, LPhT, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.997, 0.996, 1" /TUlongSig="SigB, SigA" /TUlongPSig="0.999, 0.753" /label="S1286" promotor_-35 complement(3075478..3075482) /Source="Nicolas_upshift_promotors" /id="U2643" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.563436563436563" /psig="0.999000999001" /xcortree=1661 /SigmaFactorBS="tcacgacgccattcatttgaaggatttgacaaTTGAAaagag ccgtgatCATGTTATAATAAGACTATAgccagtttgagtgagagcttgatattttctc c" /listShort="ssrA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3075520) /Source="Nicolas_upshifts" /id="U2644" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.701298701298701" /psig="0.997002997002997" /xcortree=1911 /SigmaFactorBS="aggcttctaaaggcatagTGCTTGATtcgaaaatcaggccTG TGCTATACTGTGTTCACGatcagatcacgacgccattcatttgaaggatttgacaatt g" /listShort="S1286, ssrA, S1285" /listLong="yvaG" /label="upshifts" promotor_-10 complement(3075521..3075540) /Source="Nicolas_upshift_promotors" /id="U2644" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.701298701298701" /psig="0.997002997002997" /xcortree=1911 /SigmaFactorBS="aggcttctaaaggcatagTGCTTGATtcgaaaatcaggccTG TGCTATACTGTGTTCACGatcagatcacgacgccattcatttgaaggatttgacaatt g" /listShort="S1286, ssrA, S1285" /listLong="yvaG" /label="promotor_-10" promotor_-35 complement(3075555..3075562) /Source="Nicolas_upshift_promotors" /id="U2644" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.701298701298701" /psig="0.997002997002997" /xcortree=1911 /SigmaFactorBS="aggcttctaaaggcatagTGCTTGATtcgaaaatcaggccTG TGCTATACTGTGTTCACGatcagatcacgacgccattcatttgaaggatttgacaatt g" /listShort="S1286, ssrA, S1285" /listLong="yvaG" /label="promotor_-35" CDS complement(3075571..3076041) /gene="smpB" /locus_tag="BSU_33600" /old_locus_tag="BSU33600" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10947848, 11395451, 11918677, 12682299, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10947848, 11395451, 11918677, 12682299, 26735940; Product type f: factor" /codon_start=1 /transl_table=11 /product="tmRNA-binding protein" /protein_id="NP_391240.1" /db_xref="EnsemblGenomes-Gn:BSU33600" /db_xref="EnsemblGenomes-Tr:CAB15365" /db_xref="GOA:O32230" /db_xref="InterPro:IPR000037" /db_xref="InterPro:IPR020081" /db_xref="InterPro:IPR023620" /db_xref="SubtiList:BG14064" /db_xref="UniProtKB/Swiss-Prot:O32230" /translation="MPKGSGKVLSQNKKANHDYFIEETYETGIVLQGTEIKSIRAGRV NLKDSFAKIERGEVFLHNMHVSPYEQGNRYNHDPLRTRKLLMHRKEINKLIGLTKEKG YSLVPLKLYLKNGFAKVLLGLGKGKKNYDKREDLKRKDAKREIERAFRDSQKGF*" /label="smpB CDS" gene complement(3075571..3076041) /gene="smpB" /locus_tag="BSU_33600" /old_locus_tag="BSU33600" /label="smpB gene" promotor_no_box 3075868..3075968 /Source="Nicolas_upshift_promotors" /id="U2645" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.94005994005994" /psig="0.018981018981019" /xcortree=38 /SigmaFactorBS="cacttctccccgttcgattttggcgaaggaatccttaaggtt tacgcggccggcgcgaatcgatttgatttcggttccttgcagaacgatgcctgtttca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 3075928 /Source="Nicolas_upshifts" /id="U2645" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.94005994005994" /psig="0.018981018981019" /xcortree=38 /SigmaFactorBS="cacttctccccgttcgattttggcgaaggaatccttaaggtt tacgcggccggcgcgaatcgatttgatttcggttccttgcagaacgatgcctgtttca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 3076038 /Source="Nicolas_upshifts" /id="D1746" /incds=0 /nref=2 /ntot=105 /MaxReadThrough="0.62459" /MaxDrop="3.18501" /score="-9.3042809" /energy="-3.3" /TU="NA" /idTUdmin="U2647" /TUdmin="-1408" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3076086..3076105) /Source="Nicolas_upshift_promotors" /id="U2646" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.375624375624376" /psig="0.996003996003996" /xcortree=1853 /SigmaFactorBS="atttgctttctttcggaaacagcttttcATTGtagcggtacg tgacaTTTGGTAAAATAGAGCGTATcgcaaaaggtggacagtttttccttagagagag g" /listShort="smpB, S1286" /listLong="ssrA, S1285, yvaG" /label="promotor_-10" upshifts complement(3076092) /Source="Nicolas_upshifts" /id="U2646" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.375624375624376" /psig="0.996003996003996" /xcortree=1853 /SigmaFactorBS="atttgctttctttcggaaacagcttttcATTGtagcggtacg tgacaTTTGGTAAAATAGAGCGTATcgcaaaaggtggacagtttttccttagagagag g" /listShort="smpB, S1286" /listLong="ssrA, S1285, yvaG" /label="upshifts" S_feature complement(3076094..3076185) /Source="Nicolas_S_feature" /locus_tag="new_3451771_3451862_c" /HighExp="Etha, S8, Cold, S7, G135, G180, G150, H2O2, M9-stat, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="0.999, 1" /TUlongSig="SigA" /TUlongPSig="0.753" /label="S1287" promotor_-35 complement(3076121..3076124) /Source="Nicolas_upshift_promotors" /id="U2646" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.375624375624376" /psig="0.996003996003996" /xcortree=1853 /SigmaFactorBS="atttgctttctttcggaaacagcttttcATTGtagcggtacg tgacaTTTGGTAAAATAGAGCGTATcgcaaaaggtggacagtttttccttagagagag g" /listShort="smpB, S1286" /listLong="ssrA, S1285, yvaG" /label="promotor_-35" CDS complement(3076186..3078525) /gene="rnr" /locus_tag="BSU_33610" /old_locus_tag="BSU33610" /EC_number="3.1.13.1" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12399495, 15805522, 15983136, 19215769, 22333191" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12399495, 15805522, 15983136, 19215769, 22333191; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease R" /protein_id="NP_391241.1" /db_xref="EnsemblGenomes-Gn:BSU33610" /db_xref="EnsemblGenomes-Tr:CAB15366" /db_xref="GOA:O32231" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR004476" /db_xref="InterPro:IPR011129" /db_xref="InterPro:IPR011805" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR013223" /db_xref="InterPro:IPR022966" /db_xref="InterPro:IPR022967" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG14065" /db_xref="UniProtKB/Swiss-Prot:O32231" /translation="MEKEAFMEKLLSFMKEEAYKPLTVQELEEMLNITEAEEFKELVK ALVALEEKGLIVRTRSDRYGIPEKMNLIKGKISAHAKGFAFLLPEDTSLSDVFIPPNE LNTAMNGDIVMVRLNSQSSGSRQEGTVIRILERAIQRVVGTYTETRNFGFVIPDDKKI TSDIFIPKNGKNGAAEGHKVVVKLTSYPEGRMNAEGEVETILGHKNDPGIDILSVIHK HGLPGEFPADAMEQASSTPDTIDEKDLKDRRDLRDQVIVTIDGADAKDLDDAVTVTKL DDGSYKLGVHIADVSHYVTENSPIDKEALERGTSVYLVDRVIPMIPHRLSNGICSLNP KVDRLTLSCEMTINSQGQVTEHEIFQSVIKTTERMTYSDVNKILVDDDEELKQKYEPL VPMFKDMERLAQILRDKRMDRGAVDFDFKEAKVLVDDEGAVKDVVIRERSVAEKLIEE FMLVANETVAEHFHWMNVPFIYRIHEEPNAEKLQKFLEFVTTFGYVVKGTAGNIHPRA LQSILDAVRDRPEETVISTVMLRSMKQAKYDPQSLGHFGLSTEFYTHFTSPIRRYPDL IVHRLIRTYLINGKVDEATQEKWAERLPDIAEHTSSMERRAVDAERETDDLKKAEYML DKIGEEFDGMISSVTNFGMFVELPNTIEGLVHVSFMTDDYYRFDEQHFAMIGERTGNV FRIGDEITVKVVDVNKDERNIDFEIVGMKGTPRRPRELDSSRSRKRGKPARKRVQSTN TPVSPAPSEEKGEWFTKPKKKKKKRGFQNAPKQKRKKKK*" /label="rnr CDS" gene complement(3076186..3078525) /gene="rnr" /locus_tag="BSU_33610" /old_locus_tag="BSU33610" /label="rnr gene" promotor_-35 3077286..3077289 /Source="Nicolas_upshift_promotors" /id="U2647" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.988011988011988" /psig="0.000999000999001" /xcortree=49 /SigmaFactorBS="ctttgcttctttgaaatcaaagtcaacggcgcCGCGgtccat ccgcttatcGCGCagaatttgagccagacgctccatgtctttgaacatcggaacaaga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3077305..3077308 /Source="Nicolas_upshift_promotors" /id="U2647" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.988011988011988" /psig="0.000999000999001" /xcortree=49 /SigmaFactorBS="ctttgcttctttgaaatcaaagtcaacggcgcCGCGgtccat ccgcttatcGCGCagaatttgagccagacgctccatgtctttgaacatcggaacaaga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3077314 /Source="Nicolas_upshifts" /id="U2647" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.988011988011988" /psig="0.000999000999001" /xcortree=49 /SigmaFactorBS="ctttgcttctttgaaatcaaagtcaacggcgcCGCGgtccat ccgcttatcGCGCagaatttgagccagacgctccatgtctttgaacatcggaacaaga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3078544..3079284) /gene="estA" /locus_tag="BSU_33620" /old_locus_tag="BSU33620" /EC_number="3.1.1.1" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1369099, 17369301; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="carboxylesterase" /protein_id="NP_391242.2" /db_xref="EnsemblGenomes-Gn:BSU33620" /db_xref="EnsemblGenomes-Tr:CAB15367" /db_xref="GOA:O32232" /db_xref="InterPro:IPR012354" /db_xref="InterPro:IPR022742" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG14066" /db_xref="UniProtKB/Swiss-Prot:O32232" /translation="MKVVTPKPFTFKGGDKAVLLLHGFTGNTADVRMLGRYLNERGYT CHAPQYEGHGVPPEELVHTGPEDWWKNVMDGYEYLKSEGYESIAACGLSLGGVFSLKL GYTVPIKGIVPMCAPMHIKSEEVMYQGVLSYARNYKKFEGKSPEQIEEEMKEFEKTPM NTLKALQDLIADVRNNVDMIYSPTFVVQARHDHMINTESANIIYNEVETDDKQLKWYE ESGHVITLDKERDLVHQDVYEFLEKLDW*" /label="estA CDS" gene complement(3078544..3079284) /gene="estA" /locus_tag="BSU_33620" /old_locus_tag="BSU33620" /label="estA gene" promotor_-10 complement(3078940..3078958) /Source="Nicolas_upshift_promotors" /id="U2648" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=745 /SigmaFactorBS="actgtcgcttggcggggttttttcgctgaaattGGGTTACac tgtacccataaaGGGAATTGTCCCAATGTGCgcaccgatgcatattaagagtgaagag g" /listShort="rnr, S1287, smpB" /listLong="S1286, ssrA" /label="promotor_-10" upshifts complement(3078952) /Source="Nicolas_upshifts" /id="U2648" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=745 /SigmaFactorBS="actgtcgcttggcggggttttttcgctgaaattGGGTTACac tgtacccataaaGGGAATTGTCCCAATGTGCgcaccgatgcatattaagagtgaagag g" /listShort="rnr, S1287, smpB" /listLong="S1286, ssrA" /label="upshifts" promotor_-35 complement(3078973..3078979) /Source="Nicolas_upshift_promotors" /id="U2648" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=745 /SigmaFactorBS="actgtcgcttggcggggttttttcgctgaaattGGGTTACac tgtacccataaaGGGAATTGTCCCAATGTGCgcaccgatgcatattaagagtgaagag g" /listShort="rnr, S1287, smpB" /listLong="S1286, ssrA" /label="promotor_-35" misc_feature complement(3079312..3079330) /Source="Nicolas_upshift_promotors" /id="U2649" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.376623376623377" /psig="0.753246753246753" /xcortree=634 /SigmaFactorBS="gtcaggcctttttcacgtttctggatgatattcaaaacgttt ttttctgattaaacTGTGGAAAACTAAAATGATcgtgcagatagaaagggagacatga g" /listShort="yvaK, rnr" /listLong="S1287, smpB, S1286, ssrA" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3079326) /Source="Nicolas_upshifts" /id="U2649" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.376623376623377" /psig="0.753246753246753" /xcortree=634 /SigmaFactorBS="gtcaggcctttttcacgtttctggatgatattcaaaacgttt ttttctgattaaacTGTGGAAAACTAAAATGATcgtgcagatagaaagggagacatga g" /listShort="yvaK, rnr" /listLong="S1287, smpB, S1286, ssrA" /label="upshifts" downshifts complement(3079414) /Source="Nicolas_upshifts" /id="D1747" /incds=0 /nref=30 /ntot=212 /MaxReadThrough="6.16751" /MaxDrop="5.2246" /score="-4.14736839" /energy="-9.1" /TU="U2650" /idTUdmin="U2649" /TUdmin="-3234" /isTUend="FALSE" /label="downshifts" CDS complement(3079416..3079646) /gene="secG" /locus_tag="BSU_33630" /old_locus_tag="BSU33630" /function="16.2: Construct biomass (Anabolism)" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10074070, 10644701, 16243836" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10074070, 10644701, 16243836; Product type f: factor" /codon_start=1 /transl_table=11 /product="preprotein translocase subunit" /protein_id="NP_391243.1" /db_xref="EnsemblGenomes-Gn:BSU33630" /db_xref="EnsemblGenomes-Tr:CAB15368" /db_xref="GOA:O32233" /db_xref="InterPro:IPR004692" /db_xref="SubtiList:BG14067" /db_xref="UniProtKB/Swiss-Prot:O32233" /translation="MHAVLITLLVIVSIALIIVVLLQSSKSAGLSGAISGGAEQLFGK QKARGLDLILHRITVVLAVLFFVLTIALAYIL*" /label="secG CDS" gene complement(3079416..3079646) /gene="secG" /locus_tag="BSU_33630" /old_locus_tag="BSU33630" /label="secG gene" promotor_-10 complement(3079676..3079695) /Source="Nicolas_upshift_promotors" /id="U2650" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=2177 /SigmaFactorBS="accaagataaaacgtcttatccggccttttggcgtctgatac agCGTGacatgccaacccttTTCATGTAAAATAGAAGTAAtgtagccagtgagtctgg a" /listShort="secG, yvaK, rnr, S1287, smpB, S1286" /listLong="ssrA, S1285, yvaG" /label="promotor_-10" upshifts complement(3079697) /Source="Nicolas_upshifts" /id="U2650" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=2177 /SigmaFactorBS="accaagataaaacgtcttatccggccttttggcgtctgatac agCGTGacatgccaacccttTTCATGTAAAATAGAAGTAAtgtagccagtgagtctgg a" /listShort="secG, yvaK, rnr, S1287, smpB, S1286" /listLong="ssrA, S1285, yvaG" /label="upshifts" promotor_-35 complement(3079710..3079713) /Source="Nicolas_upshift_promotors" /id="U2650" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=2177 /SigmaFactorBS="accaagataaaacgtcttatccggccttttggcgtctgatac agCGTGacatgccaacccttTTCATGTAAAATAGAAGTAAtgtagccagtgagtctgg a" /listShort="secG, yvaK, rnr, S1287, smpB, S1286" /listLong="ssrA, S1285, yvaG" /label="promotor_-35" promotor_-35 3079735..3079741 /Source="Nicolas_upshift_promotors" /id="U2651" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=928 /SigmaFactorBS="aagggttggcatgtcacgctgtatcagacgccaaaaggcCGG ATAAgacgttttatcttGGTTACCCTATTcatatgaaaaggtcaaaggagaaaagcga t" /listShort="yvaM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3079755..3079766 /Source="Nicolas_upshift_promotors" /id="U2651" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=928 /SigmaFactorBS="aagggttggcatgtcacgctgtatcagacgccaaaaggcCGG ATAAgacgttttatcttGGTTACCCTATTcatatgaaaaggtcaaaggagaaaagcga t" /listShort="yvaM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3079756 /Source="Nicolas_upshifts" /id="U2651" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=928 /SigmaFactorBS="aagggttggcatgtcacgctgtatcagacgccaaaaggcCGG ATAAgacgttttatcttGGTTACCCTATTcatatgaaaaggtcaaaggagaaaagcga t" /listShort="yvaM" /GFF_Attribute="listLong" /label="upshifts" CDS 3079795..3080565 /gene="yvaM" /locus_tag="BSU_33640" /old_locus_tag="BSU33640" /EC_number="3.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_391244.1" /db_xref="EnsemblGenomes-Gn:BSU33640" /db_xref="EnsemblGenomes-Tr:CAB15369" /db_xref="GOA:O32234" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG14068" /db_xref="UniProtKB/Swiss-Prot:O32234" /translation="MPLISIDSRKHLFYEEYGQGIPIIFIHPPGMGRKVFYYQRLLSK HFRVIFPDLSGHGDSDHIDQPASISYYANEIAQFMDALHIDKAVLFGYSAGGLIAQHI GFTRPDKVSHLILSGAYPAVHNVIGQKLHKLGMYLLEKNPGLLMKILAGSHTKDRQLR SILTDHMKKADQAHWHQYYLDSLGYNCIEQLPRLEMPMLFMYGGLRDWTFTNAGYYRR SCRHAEFFRLEYQGHQLPTKQWKTCNELVTGFVLTHHS*" /label="yvaM CDS" gene 3079795..3080565 /gene="yvaM" /locus_tag="BSU_33640" /old_locus_tag="BSU33640" /label="yvaM gene" promotor_-35 3079817..3079825 /Source="Nicolas_upshift_promotors" /id="U2652" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=538 /SigmaFactorBS="cagcatagacaGCAGGAAACatcttttttaTGAAGAATATGG ACAGGGAatccctatcatttttatccacccgccgggcatgggacgaaaggttttttat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3079836..3079854 /Source="Nicolas_upshift_promotors" /id="U2652" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=538 /SigmaFactorBS="cagcatagacaGCAGGAAACatcttttttaTGAAGAATATGG ACAGGGAatccctatcatttttatccacccgccgggcatgggacgaaaggttttttat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3079866 /Source="Nicolas_upshifts" /id="U2652" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=538 /SigmaFactorBS="cagcatagacaGCAGGAAACatcttttttaTGAAGAATATGG ACAGGGAatccctatcatttttatccacccgccgggcatgggacgaaaggttttttat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3080605..3080838) /gene="yvzC" /locus_tag="BSU_33650" /old_locus_tag="BSU33650" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative phage-like transcriptional regulator" /protein_id="NP_391245.1" /db_xref="EnsemblGenomes-Gn:BSU33650" /db_xref="EnsemblGenomes-Tr:CAB15370" /db_xref="GOA:O32235" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="SubtiList:BG14159" /db_xref="UniProtKB/Swiss-Prot:O32235" /translation="MPVEKIQIRRDYVLQYMVNNDYSLNQLALEIGVSPATLSRVLNG ERRPGQLVIGKMLHYFNLKFEDLFYYDFVDKSQ*" /label="yvzC CDS" gene complement(3080605..3080838) /gene="yvzC" /locus_tag="BSU_33650" /old_locus_tag="BSU33650" /label="yvzC gene" promotor_-35 3080929..3080936 /Source="Nicolas_upshift_promotors" /id="U2653" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5994005994006" /psig="0.985014985014985" /xcortree=2531 /SigmaFactorBS="attacggcttatgttaacttttgtcaatacatttccagtcta cctATTCCCTTtagtcaataaaCATACTAAAATATGAGTAACagtgagggacggggtg a" /listShort="rghRA, rghRB, yvaP" /listLong="S1288, yvaQ" /label="promotor_-35" upshifts 3080944 /Source="Nicolas_upshifts" /id="U2653" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5994005994006" /psig="0.985014985014985" /xcortree=2531 /SigmaFactorBS="attacggcttatgttaacttttgtcaatacatttccagtcta cctATTCCCTTtagtcaataaaCATACTAAAATATGAGTAACagtgagggacggggtg a" /listShort="rghRA, rghRB, yvaP" /listLong="S1288, yvaQ" /label="upshifts" promotor_-10 3080948..3080967 /Source="Nicolas_upshift_promotors" /id="U2653" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5994005994006" /psig="0.985014985014985" /xcortree=2531 /SigmaFactorBS="attacggcttatgttaacttttgtcaatacatttccagtcta cctATTCCCTTtagtcaataaaCATACTAAAATATGAGTAACagtgagggacggggtg a" /listShort="rghRA, rghRB, yvaP" /listLong="S1288, yvaQ" /label="promotor_-10" CDS 3080990..3081397 /gene="rghRA" /locus_tag="BSU_33660" /old_locus_tag="BSU33660" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16553878, 17227471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16553878, 17227471; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor" /protein_id="NP_391246.1" /db_xref="EnsemblGenomes-Gn:BSU33660" /db_xref="EnsemblGenomes-Tr:CAB15371" /db_xref="GOA:O32236" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR016759" /db_xref="SubtiList:BG14069" /db_xref="UniProtKB/Swiss-Prot:O32236" /translation="MESFGEQLRALREERKLTVNQLATYSGVSAAGISRIENGKRGVP KPATIKKLAEALKIPYEGLMYKAGYIEEVHEARAPYETKCKLLEKAEAYDLKNLALLE NEKWQYLNKEDLLMLDHYFSFISDEAKKRSADD*" /label="rghRA CDS" gene 3080990..3081397 /gene="rghRA" /locus_tag="BSU_33660" /old_locus_tag="BSU33660" /label="rghRA gene" CDS 3081427..3081846 /gene="rghRB" /locus_tag="BSU_33670" /old_locus_tag="BSU33670" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17227471; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative phage-like transcriptional repressor" /protein_id="NP_391247.1" /db_xref="EnsemblGenomes-Gn:BSU33670" /db_xref="EnsemblGenomes-Tr:CAB15372" /db_xref="GOA:O32237" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR016759" /db_xref="SubtiList:BG14070" /db_xref="UniProtKB/Swiss-Prot:O32237" /translation="MSPFGQQLRELRRARKLTVNQLAVYSGISSATISKIENGKRGTP KPATIKKLAAVLKVPYENLMAAAGHIQAFPEEIREASEGYQSVYEIYQTAVTRGAEHL PIFNSQKWEHLSKQDIENLSKYFDFLSSEAKKRASSS*" /label="rghRB CDS" gene 3081427..3081846 /gene="rghRB" /locus_tag="BSU_33670" /old_locus_tag="BSU33670" /label="rghRB gene" promotor_-35 3081884..3081891 /Source="Nicolas_upshift_promotors" /id="U2654" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.929070929070929" /psig=1 /xcortree=2041 /SigmaFactorBS="tgtttctctttctatattttatcaatcacgctTGCATGCCct ccctcgttattTGCGTTATAATAGTGACAGAcgaggtgaaaagtatgaaccaatcaga a" /listShort="yvaP, S1288, yvaQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3081905..3081924 /Source="Nicolas_upshift_promotors" /id="U2654" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.929070929070929" /psig=1 /xcortree=2041 /SigmaFactorBS="tgtttctctttctatattttatcaatcacgctTGCATGCCct ccctcgttattTGCGTTATAATAGTGACAGAcgaggtgaaaagtatgaaccaatcaga a" /listShort="yvaP, S1288, yvaQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3081912 /Source="Nicolas_upshifts" /id="U2654" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.929070929070929" /psig=1 /xcortree=2041 /SigmaFactorBS="tgtttctctttctatattttatcaatcacgctTGCATGCCct ccctcgttattTGCGTTATAATAGTGACAGAcgaggtgaaaagtatgaaccaatcaga a" /listShort="yvaP, S1288, yvaQ" /GFF_Attribute="listLong" /label="upshifts" CDS 3081938..3082264 /gene="catR" /locus_tag="BSU_33680" /old_locus_tag="BSU33680" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:20639328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20639328; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of catechol dioxygenase" /protein_id="NP_391248.2" /db_xref="EnsemblGenomes-Gn:BSU33680" /db_xref="EnsemblGenomes-Tr:CAB15373" /db_xref="GOA:O32238" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG14071" /db_xref="UniProtKB/Swiss-Prot:O32238" /translation="MNQSEMCPRFEKAVDILSKRWVALIVFQLLNGSQRFSEIEAALP NLSGRVLSERLKELELEGVVKRDVIPETPVRIEYSLTDKGKALAPILGEISKWATEWI DPSFLD*" /label="catR CDS" gene 3081938..3082264 /gene="catR" /locus_tag="BSU_33680" /old_locus_tag="BSU33680" /label="catR gene" S_feature 3082265..3082349 /Source="Nicolas_S_feature" /locus_tag="new_3457942_3458026" /HighExp="Cold, H2O2, Diami, LBGstat, LPhT, dia15, G180, Paraq, Etha, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.985" /label="S1288" promotor_-35 3082320..3082327 /Source="Nicolas_upshift_promotors" /id="U2655" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2826 /SigmaFactorBS="acgagaaaagaaccgttttttattttccaGGTGAAAAaaaga tatctcaGCCGATATATAGTACATCCacacattacgtttttaaaggagaccactatat g" /listShort="yvaQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3082340..3082358 /Source="Nicolas_upshift_promotors" /id="U2655" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2826 /SigmaFactorBS="acgagaaaagaaccgttttttattttccaGGTGAAAAaaaga tatctcaGCCGATATATAGTACATCCacacattacgtttttaaaggagaccactatat g" /listShort="yvaQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3082351 /Source="Nicolas_upshifts" /id="U2655" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2826 /SigmaFactorBS="acgagaaaagaaccgttttttattttccaGGTGAAAAaaaga tatctcaGCCGATATATAGTACATCCacacattacgtttttaaaggagaccactatat g" /listShort="yvaQ" /GFF_Attribute="listLong" /label="upshifts" CDS 3082389..3084089 /gene="yvaQ" /locus_tag="BSU_33690" /old_locus_tag="BSU33690" /function="16.3: Control" /function="16.12: Sense" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8188684, 11872722, 27899502; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative methyl-accepting transducer" /protein_id="NP_391249.1" /db_xref="EnsemblGenomes-Gn:BSU33690" /db_xref="EnsemblGenomes-Tr:CAB15374" /db_xref="GOA:O32239" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR004090" /db_xref="InterPro:IPR024478" /db_xref="InterPro:IPR035440" /db_xref="SubtiList:BG14072" /db_xref="UniProtKB/Swiss-Prot:O32239" /translation="MRLTISRKFSLVFLTLILINLLVGGIGVLNMQHIIQKTDEINTK WIDGIKGITSINYVTEHLSSKEKDFLIYTDKSKMDTLDQEMNQIMEDINQKLDNYEKT ISTDKEQKLFEQLQTKVNTYMDIHAQIIESGRTNDMDKARGLLVQTEASFEDMKKTIT QLVDLNQEGSNTAVKETKAVYHKGLIYTALLVAASILISIFIWLYITRNIVKPIIRMK ESANHIAEGDLSNDMEALNSKDELGDLNEALQKMVGNLRDIVGYSKDISSRVLSSSQV LATATNETRSGSKHITETMNEMAEGSEQQAQDAVTIAESMNEFTESIDKAYNHGITIS DTSQNVLELAVSGNENMATSLQQMKTIHHIVEEAVHKVRSLEQHSQDINKLVQVINGI AEQTNLLSLNAAIEAARAGESGKGFAVVAEEVRKLADGVSDSVQDITRIVNGTQQEIH TVITYLESSFTEVEKGTENLTDTGQAMQHIKQSVTHVADSIKEVTDGLKQLTNQSITI NQSIENIASVSEESAAGIEETFSITEQSAHSMDQVLLNAEELEQLANELNEKMGQFTI *" /label="yvaQ CDS" gene 3082389..3084089 /gene="yvaQ" /locus_tag="BSU_33690" /old_locus_tag="BSU33690" /label="yvaQ gene" S_feature complement(3083105..3084098) /Source="Nicolas_S_feature" /locus_tag="new_3458782_3459775_c" /HighExp="S6, S5, S7, C30, S8, S4, S3, LoTm, BT, B36" /AntisenseName="yvaQ" /AntisenseCor="-0.38660715434937498" /AntisenseRegPval="-10.3" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1289" downshifts 3084067 /Source="Nicolas_upshifts" /id="D1748" /incds=0 /nref=30 /ntot=152 /MaxReadThrough="1.43789" /MaxDrop="3.86744" /score="26.1532813" /energy="-12.2" /TU="NA" /idTUdmin="U2655" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3084129..3084809) /gene="opuBD" /locus_tag="BSU_33700" /old_locus_tag="BSU33700" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9925583, 10216873, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9925583, 10216873, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="choline ABC transporter (permease)" /protein_id="NP_391250.1" /db_xref="EnsemblGenomes-Gn:BSU33700" /db_xref="EnsemblGenomes-Tr:CAB15375" /db_xref="GOA:P39775" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12636" /db_xref="UniProtKB/Swiss-Prot:P39775" /translation="MNVLEQLMTYYAQNGSYVMDEFGRHFLMSAYGVLFAAVVGVPAG ILIAHFRRLSAWVFAVTNVIQTIPALAMLAVLMLVMGLGANTVILSLFLYSLLPIIRN TYTGIISIEHAYLESGKAMGMTKFQVLRMVELPLALSVIMAGLRTALVIAIGITAIGT FVGAGGLGDMIVRGSNATNGTAIILAGAIPTAVMAVGADLLMAWLERALSPVKKKRTG AKHVQSAA*" /label="opuBD CDS" gene complement(3084129..3084809) /gene="opuBD" /locus_tag="BSU_33700" /old_locus_tag="BSU33700" /label="opuBD gene" downshifts complement(3084143) /Source="Nicolas_upshifts" /id="D1749" /incds=0 /nref=119 /ntot=171 /MaxReadThrough="3.12805" /MaxDrop="5.39624" /score="35.0134287" /energy="-12.2" /TU="NA" /idTUdmin="U2657" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 3084503..3084509 /Source="Nicolas_upshift_promotors" /id="U2656" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=210 /SigmaFactorBS="taggcatgttcaatactgataatgcctgtgtacgTGTTTCGa ataatcggcagcaGGGAATACAGAAATAATGAtagaatcacggtatttgcgccgagcc c" /listShort="S1290" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3084524..3084542 /Source="Nicolas_upshift_promotors" /id="U2656" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=210 /SigmaFactorBS="taggcatgttcaatactgataatgcctgtgtacgTGTTTCGa ataatcggcagcaGGGAATACAGAAATAATGAtagaatcacggtatttgcgccgagcc c" /listShort="S1290" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3084529..3087280 /Source="Nicolas_S_feature" /locus_tag="new_3460206_3462957" /HighExp="Sw, M9-stat, B60, Salt, LoTm, T0.30H, BC, Gly, B36, T1.0H" /AntisenseName="opuBC" /AntisenseCor="-0.13125567572652899" /AntisenseRegPval="-1.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1290" upshifts 3084529 /Source="Nicolas_upshifts" /id="U2656" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=210 /SigmaFactorBS="taggcatgttcaatactgataatgcctgtgtacgTGTTTCGa ataatcggcagcaGGGAATACAGAAATAATGAtagaatcacggtatttgcgccgagcc c" /listShort="S1290" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3084826..3085746) /gene="opuBC" /locus_tag="BSU_33710" /old_locus_tag="BSU33710" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9925583, 10216873" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9925583, 10216873; Product type t: transporter" /codon_start=1 /transl_table=11 /product="choline ABC transporter (choline-binding lipoprotein)" /protein_id="NP_391251.1" /db_xref="EnsemblGenomes-Gn:BSU33710" /db_xref="EnsemblGenomes-Tr:CAB15376" /db_xref="GOA:Q45462" /db_xref="InterPro:IPR007210" /db_xref="PDB:3R6U" /db_xref="SubtiList:BG12635" /db_xref="UniProtKB/Swiss-Prot:Q45462" /translation="MKRKYLKLMIGLALAATLTLSGCSLPGLSAAADQTIKIGAQSMS ESEIIASMLGQLIEHHTDLKTTTIKNLGSNAVQQQALMNGEIDIAATRYTGDALTGTL RMEPEKDPDKALALTQREFKKRYDLKWYDSYGFDNTYAFTVSKELADQYHLETVSDVK KWAPQLKLGVDNYWMKLKGNGYQDFTKTYGMTFGGTYPMQIGLVYDAVKSGKMDIVLA YSTDGRIKSYGLKMLKDDKQFFPPYDCSPVVPEKVLKEHPELEGIIKKMLGKIDTATM QELNYEVDGNLKEPSVVAKEYLEKHRYFES*" /label="opuBC CDS" gene complement(3084826..3085746) /gene="opuBC" /locus_tag="BSU_33710" /old_locus_tag="BSU33710" /label="opuBC gene" CDS complement(3085758..3086411) /gene="opuBB" /locus_tag="BSU_33720" /old_locus_tag="BSU33720" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9925583, 10216873, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9925583, 10216873, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="choline ABC transporter (permease)" /protein_id="NP_391252.1" /db_xref="EnsemblGenomes-Gn:BSU33720" /db_xref="EnsemblGenomes-Tr:CAB15377" /db_xref="GOA:Q45461" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12634" /db_xref="UniProtKB/Swiss-Prot:Q45461" /translation="MHHIVQFLQTNGGELLYKTYEHITISLIAVILGVLVAVPLGVVL TRMKKGAGTIIGIVNIIQTLPSLAILAFFIPLLGVGKVPAIVALFFYSVLPILRNTYT GIRGVNKNLLESGKGIGMTPAEQVRLVELPLAAPVIMAGIRTSTIYLIGWATLASFIG GGGLGDYIFIGLNLYQPEYIIGGAVPVTILAIVIDYVLAVAERKLTPAGMQRLKELS* " /label="opuBB CDS" gene complement(3085758..3086411) /gene="opuBB" /locus_tag="BSU_33720" /old_locus_tag="BSU33720" /label="opuBB gene" CDS complement(3086428..3087573) /gene="opuBA" /locus_tag="BSU_33730" /old_locus_tag="BSU33730" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9925583, 10216873, 18321243, 21658392" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9925583, 10216873, 18321243, 21658392; Product type t: transporter" /codon_start=1 /transl_table=11 /product="choline ABC transporter (ATP-binding protein)" /protein_id="NP_391253.1" /db_xref="EnsemblGenomes-Gn:BSU33730" /db_xref="EnsemblGenomes-Tr:CAB15378" /db_xref="GOA:Q45460" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005892" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12633" /db_xref="UniProtKB/Swiss-Prot:Q45460" /translation="MLTLENVSKTYKGGKKAVNNVNLKIAKGEFICFIGPSGCGKTTT MKMINRLIEPSAGKIFIDGENIMDQDPVELRRKIGYVIQQIGLFPHMTIQQNISLVPK LLKWPEQQRKERARELLKLVDMGPEYVDRYPHELSGGQQQRIGVLRALAAEPPLILMD EPFGALDPITRDSLQEEFKKLQKTLHKTIVFVTHDMDEAIKLADRIVILKAGEIVQVG TPDDILRNPADEFVEEFIGKERLIQSSSPDVERVDQIMNTQPVTITADKTLSEAIQLM RQERVDSLLVVNDERVLQGYVDVEIIDQCRKKANLVSEVLHEDIYTVLGGTLLRDTVR KILKRGVKYVPVVDEDRRLIGIVTRASLVDIVYDSLWGEEKQLAALS*" /label="opuBA CDS" gene complement(3086428..3087573) /gene="opuBA" /locus_tag="BSU_33730" /old_locus_tag="BSU33730" /label="opuBA gene" S_feature complement(3087574..3087641) /Source="Nicolas_S_feature" /locus_tag="new_3463251_3463318_c" /HighExp="T5.0H, T3.30H, T3.0H, T-5.40H, T4.0H, T-0.40H, T-1.40H, T2.30H, T-3.40H, T-2.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1291" upshifts complement(3087641) /Source="Nicolas_upshifts" /id="U2657" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.954045954045954" /psig=1 /xcortree=3047 /SigmaFactorBS="aataatatgaacaaattgtaaaCTTTttattttataaactTT ATTCTATAATGGGAAGCAttcaattgtctgaaaaattaaatttaaactgaacaaattg a" /listShort="S1291, opuBA, opuBB, opuBC, opuBD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3087642..3087661) /Source="Nicolas_upshift_promotors" /id="U2657" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.954045954045954" /psig=1 /xcortree=3047 /SigmaFactorBS="aataatatgaacaaattgtaaaCTTTttattttataaactTT ATTCTATAATGGGAAGCAttcaattgtctgaaaaattaaatttaaactgaacaaattg a" /listShort="S1291, opuBA, opuBB, opuBC, opuBD" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 3087672..3087676 /Source="Nicolas_upshift_promotors" /id="U2658" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.804195804195804" /psig="0.804195804195804" /xcortree=1202 /SigmaFactorBS="ttgaatgcttcccattatagaataaagtttataaaATAAAaa gtttacaatttgtTCATATTATTTATAAAGTAtgtgtaaacgctgatttacccgcatt g" /listShort="yvaV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(3087676..3087679) /Source="Nicolas_upshift_promotors" /id="U2657" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.954045954045954" /psig=1 /xcortree=3047 /SigmaFactorBS="aataatatgaacaaattgtaaaCTTTttattttataaactTT ATTCTATAATGGGAAGCAttcaattgtctgaaaaattaaatttaaactgaacaaattg a" /listShort="S1291, opuBA, opuBB, opuBC, opuBD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3087692..3087710 /Source="Nicolas_upshift_promotors" /id="U2658" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.804195804195804" /psig="0.804195804195804" /xcortree=1202 /SigmaFactorBS="ttgaatgcttcccattatagaataaagtttataaaATAAAaa gtttacaatttgtTCATATTATTTATAAAGTAtgtgtaaacgctgatttacccgcatt g" /listShort="yvaV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3087697 /Source="Nicolas_upshifts" /id="U2658" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.804195804195804" /psig="0.804195804195804" /xcortree=1202 /SigmaFactorBS="ttgaatgcttcccattatagaataaagtttataaaATAAAaa gtttacaatttgtTCATATTATTTATAAAGTAtgtgtaaacgctgatttacccgcatt g" /listShort="yvaV" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3087792..3087796 /Source="Nicolas_upshift_promotors" /id="U2659" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2455 /SigmaFactorBS="tattgctccaatttcctgccaaattctcttttgacagCATTT tcgccgtatcaaaaaTGTGGTATATTGACATCGGAattgttagctgaaaggatgaaac c" /listShort="yvaV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3087812..3087831 /Source="Nicolas_upshift_promotors" /id="U2659" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2455 /SigmaFactorBS="tattgctccaatttcctgccaaattctcttttgacagCATTT tcgccgtatcaaaaaTGTGGTATATTGACATCGGAattgttagctgaaaggatgaaac c" /listShort="yvaV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3087815 /Source="Nicolas_upshifts" /id="U2659" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2455 /SigmaFactorBS="tattgctccaatttcctgccaaattctcttttgacagCATTT tcgccgtatcaaaaaTGTGGTATATTGACATCGGAattgttagctgaaaggatgaaac c" /listShort="yvaV" /GFF_Attribute="listLong" /label="upshifts" CDS 3087857..3088390 /gene="yvaV" /locus_tag="BSU_33740" /old_locus_tag="BSU33740" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (controlling choline uptake)" /protein_id="NP_391254.2" /db_xref="EnsemblGenomes-Gn:BSU33740" /db_xref="EnsemblGenomes-Tr:CAB15379" /db_xref="GOA:C0SPB8" /db_xref="InterPro:IPR026282" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG14073" /db_xref="UniProtKB/Swiss-Prot:C0SPB8" /translation="MEKDPLTIIEQAEDHFIERIAENMHAFGMPSTVGRVLGIIYMNR KPMTLTELSEATGMSKTRMSQVVREMLDANIAEKVFEKGVRKDLYEVEQDYYQTFITL FSATWSKVVSKNKMMHKKLNRELLSVLDEELTPEAEEKVNELLKELKEWLDYYNWLSR LIEFFESEDIFKYVPKP*" /label="yvaV CDS" gene 3087857..3088390 /gene="yvaV" /locus_tag="BSU_33740" /old_locus_tag="BSU33740" /label="yvaV gene" S_feature complement(3088057..3088576) /Source="Nicolas_S_feature" /locus_tag="new_3463734_3464253_c" /HighExp="S8, Cold, C30, GM 25, GM 60, BC, T-4.40H, M/G, GM-0.1, MG 120" /AntisenseName="yvaV" /AntisenseCor="-7.6123637680436104E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.503, 1, 0.758" /TUlongSig="NA" /TUlongPSig="NA" /label="S1292" downshifts 3088379 /Source="Nicolas_upshifts" /id="D1750" /incds=0 /nref=51 /ntot=161 /MaxReadThrough="2.68472" /MaxDrop="4.69377" /score="-3.5823381" /energy="-8.6" /TU="NA" /idTUdmin="U2659" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 3088513..3088520 /Source="Nicolas_upshift_promotors" /id="U2660" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=2868 /SigmaFactorBS="taatgcataatttacattaatttattaattatccatttttTG TTGATTattctgactagctaTTATATAATCTTTTTGAAATgattatattagcttagag g" /listShort="S1293, sdpA, sdpB, spbC, S1297" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3088533..3088611 /Source="Nicolas_S_feature" /locus_tag="new_3464210_3464288" /HighExp="T-1.10H, T2.30H, T4.0H, T5.0H, T-2.40H, T2.0H, T-0.40H, M9-stat, T-5.40H, T1.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1293" upshifts 3088533 /Source="Nicolas_upshifts" /id="U2660" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=2868 /SigmaFactorBS="taatgcataatttacattaatttattaattatccatttttTG TTGATTattctgactagctaTTATATAATCTTTTTGAAATgattatattagcttagag g" /listShort="S1293, sdpA, sdpB, spbC, S1297" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3088535..3088554 /Source="Nicolas_upshift_promotors" /id="U2660" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=2868 /SigmaFactorBS="taatgcataatttacattaatttattaattatccatttttTG TTGATTattctgactagctaTTATATAATCTTTTTGAAATgattatattagcttagag g" /listShort="S1293, sdpA, sdpB, spbC, S1297" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(3088561..3088575) /Source="Nicolas_upshift_promotors" /id="U2661" /multdbtbs="-" /comp="M15" /sig="SigA" /pcomp="0.483516483516484" /psig="0.503496503496504" /xcortree=2951 /SigmaFactorBS="aaaataataggaaacatatagtcattacagtaataattccct tttttttgaTgtagattacCTCCTCTAAGCTAATataatcatttcaaaaagattatat a" /listShort="S1292" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3088576) /Source="Nicolas_upshifts" /id="U2661" /multdbtbs="-" /comp="M15" /sig="SigA" /pcomp="0.483516483516484" /psig="0.503496503496504" /xcortree=2951 /SigmaFactorBS="aaaataataggaaacatatagtcattacagtaataattccct tttttttgaTgtagattacCTCCTCTAAGCTAATataatcatttcaaaaagattatat a" /listShort="S1292" /GFF_Attribute="listLong" /label="upshifts" CDS 3088612..3089088 /gene="sdpA" /locus_tag="BSU_33750" /old_locus_tag="BSU33750" /function="16.11: Scavenge (Catabolism)" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16469701, 17069462, 23687264" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16469701, 17069462, 23687264; Product type f: factor" /codon_start=1 /transl_table=11 /product="export step of killing factor SdpC" /protein_id="NP_391255.1" /db_xref="EnsemblGenomes-Gn:BSU33750" /db_xref="EnsemblGenomes-Tr:CAB15380" /db_xref="GOA:O34889" /db_xref="InterPro:IPR023902" /db_xref="SubtiList:BG14074" /db_xref="UniProtKB/Swiss-Prot:O34889" /translation="MTICFLLFSSYYFSNISPQNPLFKKNFLQQLSPQGFGFYSKSPT EENISFHTKENLKLPNALPNNFFGIKREGRVQAIELGKIVENIDPKNWKTCENNNSCT NLEKQIKPIKVIKNEDYIHLSKGEYLIYRQKPLSWYWIDFKQTTSFERKVLKIKIV*" /label="sdpA CDS" gene 3088612..3089088 /gene="sdpA" /locus_tag="BSU_33750" /old_locus_tag="BSU33750" /label="sdpA gene" promotor_-10 complement(3088637..3088656) /Source="Nicolas_upshift_promotors" /id="U2662" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.797202797202797" /psig=1 /xcortree=3097 /SigmaFactorBS="agacaattgttgcaaaaaattttttttgaacaGTGGATTCtg aggtgaaatATTGCTAAAGTAATAAGAAGaaaataataggaaacatatagtcattaca g" /listShort="S1292" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3088647) /Source="Nicolas_upshifts" /id="U2662" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.797202797202797" /psig=1 /xcortree=3097 /SigmaFactorBS="agacaattgttgcaaaaaattttttttgaacaGTGGATTCtg aggtgaaatATTGCTAAAGTAATAAGAAGaaaataataggaaacatatagtcattaca g" /listShort="S1292" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3088668..3088675) /Source="Nicolas_upshift_promotors" /id="U2662" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.797202797202797" /psig=1 /xcortree=3097 /SigmaFactorBS="agacaattgttgcaaaaaattttttttgaacaGTGGATTCtg aggtgaaatATTGCTAAAGTAATAAGAAGaaaataataggaaacatatagtcattaca g" /listShort="S1292" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3089085..3090056 /gene="sdpB" /locus_tag="BSU_33760" /old_locus_tag="BSU33760" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15743949, 15849754, 16469701, 16850406, 17069462, 23687264" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15743949, 15849754, 16469701, 16850406, 17069462, 23687264; Product type t : transporter" /codon_start=1 /transl_table=11 /product="export step of killing factor SdpC" /protein_id="NP_391256.1" /db_xref="EnsemblGenomes-Gn:BSU33760" /db_xref="EnsemblGenomes-Tr:CAB15381" /db_xref="GOA:O34616" /db_xref="InterPro:IPR007782" /db_xref="InterPro:IPR011020" /db_xref="InterPro:IPR023894" /db_xref="SubtiList:BG14075" /db_xref="UniProtKB/Swiss-Prot:O34616" /translation="MKILNSLEGYIDTYNPWKNTYALFRSLLGFSTLLVLLFNSTDIL FSYSANNVTCENVYIPTAFCFAKEYSINFEIIRYLMIFILTLVVIGWRPRFTGLFHWY ICYSIQTSALTIDGGEQIATVLSFLILPVTLLDSRRNHWNIKKNNNESFTKKTVLFYI MTIIKIQVFIIYLNAALERLKNKEWAEGTAIYYFFSDPVFGLPEYQLNLMNPLLESNF IVVITWLVTIFELFLAASIISNIRIKRIALVLGILFHIGIIFSIGIVSFGLIMISALI IYLHPVQQNITMNWCSPLFKYIYVKGKRNFKRIGGESVKFLTKLFHS*" /label="sdpB CDS" gene 3089085..3090056 /gene="sdpB" /locus_tag="BSU_33760" /old_locus_tag="BSU33760" /label="sdpB gene" promotor_no_box 3089893..3089993 /Source="Nicolas_upshift_promotors" /id="U2663" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.457542457542458" /psig="0.636363636363636" /xcortree=2869 /SigmaFactorBS="tcatgatatcagcattaattatatatctgcatcctgtacaac aaaatatcactatgaattggtgttctcctttatttaaatatatatatgtaaaaggaaa g" /listShort="spbC, S1297" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 3089953 /Source="Nicolas_upshifts" /id="U2663" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.457542457542458" /psig="0.636363636363636" /xcortree=2869 /SigmaFactorBS="tcatgatatcagcattaattatatatctgcatcctgtacaac aaaatatcactatgaattggtgttctcctttatttaaatatatatatgtaaaaggaaa g" /listShort="spbC, S1297" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3089965..3089982) /Source="Nicolas_upshift_promotors" /id="U2664" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig="0.758241758241758" /xcortree=423 /SigmaFactorBS="aacaattttgtaagaaacttgactgattcacctcctattctt ttgAAAtttctctttccttttaCATATATATATTTAAATAaaggagaacaccaattca t" /listShort="S1292" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3089986) /Source="Nicolas_upshifts" /id="U2664" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig="0.758241758241758" /xcortree=423 /SigmaFactorBS="aacaattttgtaagaaacttgactgattcacctcctattctt ttgAAAtttctctttccttttaCATATATATATTTAAATAaaggagaacaccaattca t" /listShort="S1292" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3089988..3090390) /Source="Nicolas_S_feature" /locus_tag="new_3465665_3466067_c" /HighExp="Gly, Lbstat, BT, S8, T1.30H, C30, M9-stat, C90, Sw, HiTm" /AntisenseName="spbC" /AntisenseCor="-0.16053929530879699" /AntisenseRegPval="-2.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1294" promotor_-35 complement(3089999..3090001) /Source="Nicolas_upshift_promotors" /id="U2664" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig="0.758241758241758" /xcortree=423 /SigmaFactorBS="aacaattttgtaagaaacttgactgattcacctcctattctt ttgAAAtttctctttccttttaCATATATATATTTAAATAaaggagaacaccaattca t" /listShort="S1292" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3090017) /Source="Nicolas_upshifts" /id="D1751" /incds=0 /nref=1 /ntot=33 /MaxReadThrough="3.26001" /MaxDrop="4.09728" /score="-7.06061287" /energy="-10.3" /TU="NA" /idTUdmin="U2665" /TUdmin=286 /isTUend="FALSE" /label="downshifts" CDS 3090099..3090710 /gene="spbC" /locus_tag="BSU_33770" /old_locus_tag="BSU33770" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /function="16.4: Excrete" /experiment="publication(s) with functional evidences, PMID:15743949, 16469701, 17069462, 23687264" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15743949, 16469701, 17069462, 23687264; Product type f: factor" /codon_start=1 /transl_table=11 /product="precursor of killing factor SdpC" /protein_id="NP_391257.1" /db_xref="EnsemblGenomes-Gn:BSU33770" /db_xref="EnsemblGenomes-Tr:CAB15382" /db_xref="GOA:O34344" /db_xref="InterPro:IPR023888" /db_xref="SubtiList:BG14076" /db_xref="UniProtKB/Swiss-Prot:O34344" /translation="MKSKLLRLLIVSMVTILVFSLVGLSKESSTSAKENHTFSGEDYF RGLLFGQGEVGKLISNDLDPKLVKEANSTEGKKLVNDVVKFIKKDQPQYMDELKQSID SKDPKKLIENMTKADQLIQKYAKKNENVKYSSNKVTPSCGLYAVCVAAGYLYVVGVNA VALQTAAAVTTAVWKYVAKYSSSASNNSDLEAAAAKTLKLIHQ*" /label="spbC CDS" gene 3090099..3090710 /gene="spbC" /locus_tag="BSU_33770" /old_locus_tag="BSU33770" /label="spbC gene" S_feature complement(3090392..3090478) /Source="Nicolas_S_feature" /locus_tag="new_3466069_3466155_c" /HighExp="T1.30H, Gly, T2.0H, BT, S8, C30, Lbstat, C90, T1.0H, M9-stat" /AntisenseName="spbC" /AntisenseCor="-5.4790207146846799E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1295" downshifts complement(3090435) /Source="Nicolas_upshifts" /id="D1752" /incds=1 /nref=1 /ntot=8 /MaxReadThrough="4.62458" /MaxDrop="2.00358" /score="8.72167152" /energy="-11.6" /TU="U2665" /idTUdmin="U2665" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" S_feature complement(3090480..3090665) /Source="Nicolas_S_feature" /locus_tag="new_3466157_3466342_c" /HighExp="T1.30H, T2.0H, M9-stat, T1.0H, B60, T2.30H, T5.0H, B36, T3.30H, T0.30H" /AntisenseName="spbC" /AntisenseCor="-4.2394313806342503E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.999" /label="S1296" downshifts complement(3090523) /Source="Nicolas_upshifts" /id="D1753" /incds=1 /nref=1 /ntot=14 /MaxReadThrough="4.27088" /MaxDrop="2.27366" /score="8.72167152" /energy="-11.6" /TU="U2665" /idTUdmin="U2665" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" downshifts 3090690 /Source="Nicolas_upshifts" /id="D1754" /incds=0 /nref=207 /ntot=252 /MaxReadThrough="4.65014" /MaxDrop="7.52715" /score="19.8036228" /energy="-20" /TU="U2660,U2663" /idTUdmin="U2660" /TUdmin="-1099" /isTUend="FALSE" /label="downshifts" downshifts complement(3090710) /Source="Nicolas_upshifts" /id="D1755" /incds=0 /nref=14 /ntot=94 /MaxReadThrough="6.14809" /MaxDrop="5.58575" /score="8.72167152" /energy="-11.6" /TU="U2665" /idTUdmin="U2667" /TUdmin=33 /isTUend="FALSE" /label="downshifts" S_feature 3090735..3091873 /Source="Nicolas_S_feature" /locus_tag="new_3466412_3467550" /HighExp="Pyr, S8, nit, C30, GM 150, M9-stat, S7, S2, G/S, S1" /AntisenseName="sdpI" /AntisenseCor="-7.9710115369408502E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.636, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1297" CDS complement(3090757..3091380) /gene="sdpI" /locus_tag="BSU_33780" /old_locus_tag="BSU33780" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12817086, 15849754, 16850406, 20563570, 23687264" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12817086, 15849754, 16850406, 20563570, 23687264; Product type r: regulator" /codon_start=1 /transl_table=11 /product="integral membrane immunity regulator of autophagy" /protein_id="NP_391258.1" /db_xref="EnsemblGenomes-Gn:BSU33780" /db_xref="EnsemblGenomes-Tr:CAB15383" /db_xref="GOA:O32241" /db_xref="InterPro:IPR012867" /db_xref="InterPro:IPR025962" /db_xref="InterPro:IPR026272" /db_xref="SubtiList:BG14077" /db_xref="UniProtKB/Swiss-Prot:O32241" /translation="MKKNIISIIIVCLSFLTSIILYQYLPEEIPIQWSGNKPAAIVSK PLTIFIIPVVMLIYYLTFYMLTIKSTQKNKALLFLASNNMLILLYILQLSTLLISLGY EVNIDLIIGLGVGIFLIIGGNSMQLAEQNHLIGLRTPWTLKDETVWKLGNRFASKVLV VCGFIIAVLSFFTGEYIILIMIVLVLLALVISTLASYHYYKKLNGSR*" /label="sdpI CDS" gene complement(3090757..3091380) /gene="sdpI" /locus_tag="BSU_33780" /old_locus_tag="BSU33780" /label="sdpI gene" downshifts complement(3090765) /Source="Nicolas_upshifts" /id="D1756" /incds=0 /nref=1 /ntot=95 /MaxReadThrough="6.43517" /MaxDrop="3.3455" /score="8.72167152" /energy="-11.6" /TU="U2665,U2667" /idTUdmin="U2667" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(3091377..3091649) /gene="sdpR" /locus_tag="BSU_33790" /old_locus_tag="BSU33790" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12817086, 17069462, 23687264" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12817086, 17069462, 23687264; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of SdpC synthesis operon (ArsR family)" /protein_id="NP_391259.1" /db_xref="EnsemblGenomes-Gn:BSU33790" /db_xref="EnsemblGenomes-Tr:CAB15384" /db_xref="GOA:O32242" /db_xref="InterPro:IPR001845" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG14078" /db_xref="UniProtKB/Swiss-Prot:O32242" /translation="MNNVFKAISDPTRRKILDLLKGGDMTAGDIAEHFNISKPSISHH LNILKQAEVISDHRKGQFIYYSLNTTVLQDSINWMLNFINKGDNDL*" /label="sdpR CDS" gene complement(3091377..3091649) /gene="sdpR" /locus_tag="BSU_33790" /old_locus_tag="BSU33790" /label="sdpR gene" promotor_-10 complement(3091705..3091724) /Source="Nicolas_upshift_promotors" /id="U2665" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.372627372627373" /psig=1 /xcortree=405 /SigmaFactorBS="tacaaaaatcagatattataaccaatttgaggGTTGTTTtta aaaaaattCAAGTTATAATGAAAATAATacatttatacaaatatctaaatgtctaaat g" /listShort="sdpR, sdpI, S1296, S1295, S1294" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3091714) /Source="Nicolas_upshifts" /id="U2665" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.372627372627373" /psig=1 /xcortree=405 /SigmaFactorBS="tacaaaaatcagatattataaccaatttgaggGTTGTTTtta aaaaaattCAAGTTATAATGAAAATAATacatttatacaaatatctaaatgtctaaat g" /listShort="sdpR, sdpI, S1296, S1295, S1294" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3091716..3091864) /Source="Nicolas_S_feature" /locus_tag="new_3467393_3467541_c" /HighExp="Salt, B36, Gly, B60, LoTm, S8, GM 5, MG 25, Cold, Mal" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1298" promotor_-35 complement(3091736..3091742) /Source="Nicolas_upshift_promotors" /id="U2665" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.372627372627373" /psig=1 /xcortree=405 /SigmaFactorBS="tacaaaaatcagatattataaccaatttgaggGTTGTTTtta aaaaaattCAAGTTATAATGAAAATAATacatttatacaaatatctaaatgtctaaat g" /listShort="sdpR, sdpI, S1296, S1295, S1294" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3091869..3092558) /gene="opuCD" /locus_tag="BSU_33800" /old_locus_tag="BSU33800" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9925583, 10216873, 15849754, 16850406, 28256787" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9925583, 10216873, 15849754, 16850406, 28256787; Product type t : transporter" /codon_start=1 /transl_table=11 /product="glycine betaine/carnitine/choline/choline sulfate ABC transporter (promiscuous permease)" /protein_id="NP_391260.1" /db_xref="EnsemblGenomes-Gn:BSU33800" /db_xref="EnsemblGenomes-Tr:CAB15385" /db_xref="GOA:O34742" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12640" /db_xref="UniProtKB/Swiss-Prot:O34742" /translation="MEVLQQLGTYYSQNGGYVLQEFYRHFLMSVYGVLFAAIVGIPLG ILIARYRRLSGWVFAVTNVIQTIPALAMLAVLMLVMGLGANTVILSLFLYSLLPIIRN TYTGIISIEHAYLESGKAMGMTKFQVLRMVELPLALSVIMAGLRTALVIAIGITAIGT FVGAGGLGDIIVRGSNATNGTAIILAGAIPTALMAVIADLVMGWLERALSPIKKKKGN FIIADRKTTSI*" /label="opuCD CDS" gene complement(3091869..3092558) /gene="opuCD" /locus_tag="BSU_33800" /old_locus_tag="BSU33800" /label="opuCD gene" downshifts complement(3091909) /Source="Nicolas_upshifts" /id="D1757" /incds=0 /nref=95 /ntot=199 /MaxReadThrough="5.55394" /MaxDrop="6.7177" /score="8.72167152" /energy="-11.6" /TU="U2667" /idTUdmin="U2667" /TUdmin="-1166" /isTUend="FALSE" /label="downshifts" promotor_-35 3092501..3092509 /Source="Nicolas_upshift_promotors" /id="U2666" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.763236763236763" /psig="0.763236763236763" /xcortree=767 /SigmaFactorBS="tcagaaaatggcggtaaaattcctGCAGCACGTaaccgccgt tttgCGAATAGTATGTGCCAAGCTgctgtagtacttccatatgatccacctcttttct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3092523..3092542 /Source="Nicolas_upshift_promotors" /id="U2666" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.763236763236763" /psig="0.763236763236763" /xcortree=767 /SigmaFactorBS="tcagaaaatggcggtaaaattcctGCAGCACGTaaccgccgt tttgCGAATAGTATGTGCCAAGCTgctgtagtacttccatatgatccacctcttttct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3092537 /Source="Nicolas_upshifts" /id="U2666" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.763236763236763" /psig="0.763236763236763" /xcortree=767 /SigmaFactorBS="tcagaaaatggcggtaaaattcctGCAGCACGTaaccgccgt tttgCGAATAGTATGTGCCAAGCTgctgtagtacttccatatgatccacctcttttct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3092576..3093487) /gene="opuCC" /locus_tag="BSU_33810" /old_locus_tag="BSU33810" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9925583, 10216873, 28256787" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9925583, 10216873, 28256787; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glycine betaine/carnitine/choline/choline sulfate ABC transporter (osmoprotectant-binding lipoprotein)" /protein_id="NP_391261.1" /db_xref="EnsemblGenomes-Gn:BSU33810" /db_xref="EnsemblGenomes-Tr:CAB15386" /db_xref="GOA:O32243" /db_xref="InterPro:IPR007210" /db_xref="PDB:3PPN" /db_xref="PDB:3PPO" /db_xref="PDB:3PPP" /db_xref="PDB:3PPQ" /db_xref="PDB:3PPR" /db_xref="SubtiList:BG12639" /db_xref="UniProtKB/Swiss-Prot:O32243" /translation="MTKIKWLGAFALVFVMLLGGCSLPGLGGASDDTIKIGAQSMTES EIVANMIAQLIEHDTDLNTALVKNLGSNYVQHQAMLGGDIDISATRYSGTDLTSTLGK EAEKDPKKALNIVQNEFQKRFSYKWFDSYGFDNTYAFTVTKKFAEKEHINTVSDLKKN ASQYKLGVDNAWLKRKGDGYKGFVSTYGFEFGTTYPMQIGLVYDAVKNGKMDAVLAYS TDGRIKAYDLKILKDDKRFFPPYDCSPVIPEKVLKEHPELEGVINKLIGQIDTETMQE LNYEVDGKLKEPSVVAKEFLEKHHYFD*" /label="opuCC CDS" gene complement(3092576..3093487) /gene="opuCC" /locus_tag="BSU_33810" /old_locus_tag="BSU33810" /label="opuCC gene" CDS complement(3093507..3094160) /gene="opuCB" /locus_tag="BSU_33820" /old_locus_tag="BSU33820" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9925583, 10216873, 15849754, 16850406, 28256787" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9925583, 10216873, 15849754, 16850406, 28256787; Product type t : transporter" /codon_start=1 /transl_table=11 /product="glycine betaine/carnitine/choline/choline sulfate ABC transporter (promiscuous permease)" /protein_id="NP_391262.1" /db_xref="EnsemblGenomes-Gn:BSU33820" /db_xref="EnsemblGenomes-Tr:CAB15387" /db_xref="GOA:O34878" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12638" /db_xref="UniProtKB/Swiss-Prot:O34878" /translation="MNQMMTFLQTNGGELLYKTGEHLYISLIAVVLGIIVAVPLGVAL TRMKKGAGAVIGFVNIVQTLPSLAILAFFIPLLGVGKVPAIVALFFYSVLPILRNTYT GIKGVNKNLLESGKGIGMTGWEQIRLVEIPLAIPIIMAGIRTSTIYLIGWATLASFIG GGGLGDYIFIGLNLYQPEYIIGGAVPVTILAIIIDYVLAVTERKVTPKGLQGMKEVS* " /label="opuCB CDS" gene complement(3093507..3094160) /gene="opuCB" /locus_tag="BSU_33820" /old_locus_tag="BSU33820" /label="opuCB gene" CDS complement(3094183..3095325) /gene="opuCA" /locus_tag="BSU_33830" /old_locus_tag="BSU33830" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10216873, 9925583, 21658392, 27378384, 27683249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10216873, 9925583, 21658392, 27378384, 27683249; Product type t : transporter" /codon_start=1 /transl_table=11 /product="glycine betaine/carnitine/choline/choline sulfate ABC transporter (ATP-binding protein)" /protein_id="NP_391263.1" /db_xref="EnsemblGenomes-Gn:BSU33830" /db_xref="EnsemblGenomes-Tr:CAB15388" /db_xref="GOA:O34992" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005892" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12637" /db_xref="UniProtKB/Swiss-Prot:O34992" /translation="MLKLEQVSKVYKGGKKAVNSIDLDIAKGEFICFIGPSGCGKTTT MKMINRLIEPSSGRIFIDGENIMEQDPVELRRKIGYVIQQIGLFPHMTIQQNISLVPK LLKWPEEKRKERARELLKLVDMGPEYLDRYPHELSGGQQQRIGVLRALAAEPPLILMD EPFGALDPITRDSLQEEFKKLQRTLNKTIVFVTHDMDEAIKLADRIVILKAGEIVQVG TPDEILRNPANEFVEEFIGKERLIQSRPDIERVEQMMNRTPVTVSADKTLSQAIQLMR EKRVDSLLVVDRQNVLKGYVDVEMIDQNRKKASIVGDVYRSDIYTVQKGALLRDTVRK ILKQGIKYVPVVDEQNHLAGIVTRASLVDIVYDSIWGDEENQLMTI*" /label="opuCA CDS" gene complement(3094183..3095325) /gene="opuCA" /locus_tag="BSU_33830" /old_locus_tag="BSU33830" /label="opuCA gene" promotor_-10 complement(3095369..3095388) /Source="Nicolas_upshift_promotors" /id="U2667" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.937062937062937" /psig="0.999000999001" /xcortree=3049 /SigmaFactorBS="taatctataaataacatataatttcaacacattgtaaaCTTT ttattttacaaagtTCAAACTATAATAAGGATTAtacttttcagaaaatttaaaggaa a" /listShort="opuCA, opuCB, opuCC, opuCD, S1298, sdpR, sdpI" /listLong="S1296" /label="promotor_-10" upshifts complement(3095384) /Source="Nicolas_upshifts" /id="U2667" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.937062937062937" /psig="0.999000999001" /xcortree=3049 /SigmaFactorBS="taatctataaataacatataatttcaacacattgtaaaCTTT ttattttacaaagtTCAAACTATAATAAGGATTAtacttttcagaaaatttaaaggaa a" /listShort="opuCA, opuCB, opuCC, opuCD, S1298, sdpR, sdpI" /listLong="S1296" /label="upshifts" promotor_-35 complement(3095403..3095406) /Source="Nicolas_upshift_promotors" /id="U2667" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.937062937062937" /psig="0.999000999001" /xcortree=3049 /SigmaFactorBS="taatctataaataacatataatttcaacacattgtaaaCTTT ttattttacaaagtTCAAACTATAATAAGGATTAtacttttcagaaaatttaaaggaa a" /listShort="opuCA, opuCB, opuCC, opuCD, S1298, sdpR, sdpI" /listLong="S1296" /label="promotor_-35" promotor_-35 3095522..3095529 /Source="Nicolas_upshift_promotors" /id="U2668" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.697302697302697" /psig="0.993006993006993" /xcortree=3046 /SigmaFactorBS="atacctcccacttcctctgcattcagctaTTTTCAACaccag gaagaaaTATGATATATTGACACCATCaattgccatttgaagggatgatcagctgtga a" /listShort="yvbF, S1299, yvbH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3095542..3095561 /Source="Nicolas_upshift_promotors" /id="U2668" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.697302697302697" /psig="0.993006993006993" /xcortree=3046 /SigmaFactorBS="atacctcccacttcctctgcattcagctaTTTTCAACaccag gaagaaaTATGATATATTGACACCATCaattgccatttgaagggatgatcagctgtga a" /listShort="yvbF, S1299, yvbH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3095553 /Source="Nicolas_upshifts" /id="U2668" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.697302697302697" /psig="0.993006993006993" /xcortree=3046 /SigmaFactorBS="atacctcccacttcctctgcattcagctaTTTTCAACaccag gaagaaaTATGATATATTGACACCATCaattgccatttgaagggatgatcagctgtga a" /listShort="yvbF, S1299, yvbH" /GFF_Attribute="listLong" /label="upshifts" CDS 3095589..3096146 /gene="opcR" /locus_tag="BSU_33840" /old_locus_tag="BSU33840" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:23960087" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23960087; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative transcriptional regulator of choline uptake systems" /protein_id="NP_391264.1" /db_xref="EnsemblGenomes-Gn:BSU33840" /db_xref="EnsemblGenomes-Tr:CAB15389" /db_xref="GOA:O34709" /db_xref="InterPro:IPR026282" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG14079" /db_xref="UniProtKB/Swiss-Prot:O34709" /translation="MKKTALDIIEHAEEHLIEKIAENMHTFGMPSTVGRVLGIIYMNR KPMTLSELSEATGMSKTRMSQVVREMIDANIAEKVFEKGVRKDLYDVEQDYYQTFISL FAANWTKVVSKNKVLYKKLNRELSDLLQRDGLTPEAEEKVNQLLNELKEWLHYYDWLS RLIEFFESEEVFRYVPKTKECSSLK*" /label="opcR CDS" gene 3095589..3096146 /gene="opcR" /locus_tag="BSU_33840" /old_locus_tag="BSU33840" /label="opcR gene" S_feature 3096147..3096911 /Source="Nicolas_S_feature" /locus_tag="new_3471824_3472588" /HighExp="HiOs, GM 5, GM 10, Salt, MG 15, MG 10, MG 25, T0.0H, T-2.40H, GM 45" /AntisenseName="yvbG" /AntisenseCor="-0.14921239095219299" /AntisenseRegPval="-1.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1299" CDS complement(3096164..3096799) /gene="yvbG" /locus_tag="BSU_33850" /old_locus_tag="BSU33850" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_391265.1" /db_xref="EnsemblGenomes-Gn:BSU33850" /db_xref="EnsemblGenomes-Tr:CAB15390" /db_xref="GOA:O32244" /db_xref="InterPro:IPR002771" /db_xref="SubtiList:BG14080" /db_xref="UniProtKB/Swiss-Prot:O32244" /translation="MMFSFIVHVFISLFAVSNPIGNVPIFLTLTEGYTAAERKAIARK AAILSFFILAAFLVFGHLIFKLFDINIHALRVAGGIFIFGIAYNLLNAKESHVQSLHH DEHKESKEKADISVTPLSIPIIAGPGTIATVMSLSAGHSGIGHYAAVMIGIAAVIALT FLFFHYSAFISSKLGKTEMNVITRLMGLILAVVAVGMIGAGLKGMFPVLTS*" /label="yvbG CDS" gene complement(3096164..3096799) /gene="yvbG" /locus_tag="BSU_33850" /old_locus_tag="BSU33850" /label="yvbG gene" downshifts complement(3096177) /Source="Nicolas_upshifts" /id="D1758" /incds=0 /nref=21 /ntot=50 /MaxReadThrough="2.02169" /MaxDrop="4.45088" /score="10.9231366" /energy="-16.4" /TU="NA" /idTUdmin="U2669" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3096840..3096858) /Source="Nicolas_upshift_promotors" /id="U2669" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=181 /SigmaFactorBS="atggcgcgtttctgacaggctataaaGGTTTACcgggaaatc gcctccGGGTAAAAGGGTGGAGAATcattctatttcctgtgcagagactatcaacaag g" /listShort="yvbG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3096846) /Source="Nicolas_upshifts" /id="U2669" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=181 /SigmaFactorBS="atggcgcgtttctgacaggctataaaGGTTTACcgggaaatc gcctccGGGTAAAAGGGTGGAGAATcattctatttcctgtgcagagactatcaacaag g" /listShort="yvbG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3096874..3096880) /Source="Nicolas_upshift_promotors" /id="U2669" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=181 /SigmaFactorBS="atggcgcgtttctgacaggctataaaGGTTTACcgggaaatc gcctccGGGTAAAAGGGTGGAGAATcattctatttcctgtgcagagactatcaacaag g" /listShort="yvbG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3096885..3096892 /Source="Nicolas_upshift_promotors" /id="U2670" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2261 /SigmaFactorBS="ttacccggaggcgatttcccggtaaacctttaTAGCCTGTca gaaacgcgcCATGCTACAATGAAGTGACAaattgaataggaaggacgtatacagatgt t" /listShort="yvbH, yvbI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3096904..3096923 /Source="Nicolas_upshift_promotors" /id="U2670" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2261 /SigmaFactorBS="ttacccggaggcgatttcccggtaaacctttaTAGCCTGTca gaaacgcgcCATGCTACAATGAAGTGACAaattgaataggaaggacgtatacagatgt t" /listShort="yvbH, yvbI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3096913 /Source="Nicolas_upshifts" /id="U2670" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2261 /SigmaFactorBS="ttacccggaggcgatttcccggtaaacctttaTAGCCTGTca gaaacgcgcCATGCTACAATGAAGTGACAaattgaataggaaggacgtatacagatgt t" /listShort="yvbH, yvbI" /GFF_Attribute="listLong" /label="upshifts" CDS 3096949..3097563 /gene="yvbH" /locus_tag="BSU_33860" /old_locus_tag="BSU33860" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391266.1" /db_xref="EnsemblGenomes-Gn:BSU33860" /db_xref="EnsemblGenomes-Tr:CAB15391" /db_xref="InterPro:IPR011993" /db_xref="InterPro:IPR012544" /db_xref="InterPro:IPR021722" /db_xref="InterPro:IPR037063" /db_xref="SubtiList:BG14081" /db_xref="UniProtKB/Swiss-Prot:O32245" /translation="MFKKIAADALGLSDIGKIIEPQDYDKTDADDYVMHEDNEKIYFL IKTKADEYCFTNLALIHVDGERATSSKRTLKRYPYSQYKISDVFLETAGKVDLDVEIK FKLGGEQFDIDVHKDQIEKLKDLYKALLRIAETTYENDILINQAEQSLDKAVTILHHT RPEHVNIETQYKELTEFGFTWLTSVRSQYHIKDFGDVFEKYINN*" /label="yvbH CDS" gene 3096949..3097563 /gene="yvbH" /locus_tag="BSU_33860" /old_locus_tag="BSU33860" /label="yvbH gene" downshifts 3097549 /Source="Nicolas_upshifts" /id="D1759" /incds=0 /nref=110 /ntot=197 /MaxReadThrough="2.66824" /MaxDrop="5.86088" /score="-4.16829989" /energy="-7.9" /TU="U2670" /idTUdmin="U2668" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" promotor_-35 3097617..3097620 /Source="Nicolas_upshift_promotors" /id="U2671" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.623376623376623" /psig=1 /xcortree=2318 /SigmaFactorBS="ctatcgtgctcgtgtctttttttgtatgaatattGATTactt tacaacttttTTCTTTTATAATAAAACTATtagtctattttccctatattacagataa a" /listShort="yvbI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3097635..3097654 /Source="Nicolas_upshift_promotors" /id="U2671" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.623376623376623" /psig=1 /xcortree=2318 /SigmaFactorBS="ctatcgtgctcgtgtctttttttgtatgaatattGATTactt tacaacttttTTCTTTTATAATAAAACTATtagtctattttccctatattacagataa a" /listShort="yvbI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3097643 /Source="Nicolas_upshifts" /id="U2671" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.623376623376623" /psig=1 /xcortree=2318 /SigmaFactorBS="ctatcgtgctcgtgtctttttttgtatgaatattGATTactt tacaacttttTTCTTTTATAATAAAACTATtagtctattttccctatattacagataa a" /listShort="yvbI" /GFF_Attribute="listLong" /label="upshifts" CDS 3097695..3098393 /gene="yvbI" /locus_tag="BSU_33870" /old_locus_tag="BSU33870" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391267.1" /db_xref="EnsemblGenomes-Gn:BSU33870" /db_xref="EnsemblGenomes-Tr:CAB15392" /db_xref="GOA:O32246" /db_xref="InterPro:IPR029038" /db_xref="SubtiList:BG14082" /db_xref="UniProtKB/Swiss-Prot:O32246" /translation="MYCPQCGHQTDGGNFCEKCGSPLPGQSGHQHAAQTGAAAKQAAK QFGSFVLSVLKRPYQECKATGGEQLISAIITMVLFSLLTPLMFYILFSDGPGSVSFTA IFLEPTIYFILFLFGLHACIFFALKIAGNQVSFKDSFSRFGAFLIPFTAILILALFFF LLHTDICFTILAVGLIGAFFAIPPAMLSSYQHSYKGKVDFIYSTIVIYLIICVTFQLI IEHYVKEIFRYMLF*" /label="yvbI CDS" gene 3097695..3098393 /gene="yvbI" /locus_tag="BSU_33870" /old_locus_tag="BSU33870" /label="yvbI gene" downshifts 3098366 /Source="Nicolas_upshifts" /id="D1760" /incds=0 /nref=72 /ntot=203 /MaxReadThrough="1.50622" /MaxDrop="4.71846" /score="17.2112529" /energy="-17.2" /TU="U2671" /idTUdmin="U2671" /TUdmin="-23" /isTUend="FALSE" /label="downshifts" CDS complement(3098429..3100246) /gene="yvbJ" /locus_tag="BSU_33880" /old_locus_tag="BSU33880" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15155184" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391268.1" /db_xref="EnsemblGenomes-Gn:BSU33880" /db_xref="EnsemblGenomes-Tr:CAB15393" /db_xref="GOA:O32247" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR026870" /db_xref="SubtiList:BG14083" /db_xref="UniProtKB/Swiss-Prot:O32247" /translation="MLFCKNCGSQNNEGAKFCKQCGTPIGGGSKQANQETASTAETRQ APRKPIPKKTIILWSSIAAACVILFAAYKTGAYFTSKDRLVDKFEQAVNDGDQDQIAT LLTPVNDNLKLTKNNVKPFLTYLKDHPDKKDELFASLRDETAQKDIVYAEKDGKSLLV FDHYDLKVAPVYFEVSSNYKNTDLYVNKEEAGSVKKADQAQTLGPYIPGEYTVSAKLK NDVVDLVKKEDIQAIGDSSFRVDLSLEADDVTFSLANDIKSGKGDLLINGKSIHKDPF KSVTYGPLLTDGSMTASVEAEFPWGKTKTAGVPIDDKEMELTLIPDQDTQEQIMNTIV KTTKQYSKALSDGNTAQMTEASANWKAETKDTVDSMKSADSYLKDRYLETDFDLDTFA LSQKNDGTWQVSVTGKELHQSSSYNDYTKSEMTDDSPSYEYLLSYDKKQKKWIFEDAE STFESAGTNIKKIKNDKPETYTSAWAGSKNKGSESSASGDVTDEQVTLFMGSYLQSQA DAVNQNNFSLMEDSLEKGSSLYSDQQHLVSKLNKEGTTEDFNNYEVKSWSQNGSAITI KTYEEFYITKSGGSPKLRTYNWTYTGVVKNGRIYLTSIQ*" /label="yvbJ CDS" gene complement(3098429..3100246) /gene="yvbJ" /locus_tag="BSU_33880" /old_locus_tag="BSU33880" /label="yvbJ gene" downshifts complement(3098448) /Source="Nicolas_upshifts" /id="D1761" /incds=0 /nref=31 /ntot=189 /MaxReadThrough="2.6958" /MaxDrop="3.67366" /score="15.9345511" /energy="-17.2" /TU="NA" /idTUdmin="U2673" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" downshifts complement(3098619) /Source="Nicolas_upshifts" /id="D1762" /incds=1 /nref=1 /ntot=106 /MaxReadThrough="4.6758" /MaxDrop="2.2812" /score="15.9345511" /energy="-17.2" /TU="U2673" /idTUdmin="U2673" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" misc_feature complement(3100288..3100307) /Source="Nicolas_upshift_promotors" /id="U2673" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.546453546453546" /psig="0.995004995004995" /xcortree=2319 /SigmaFactorBS="cctttttagtctgatagacatttaattttttcattcgttccc aatttcattctgTTTTATTATAAAATATGAAAagcagtaaatgttatcaaattagtag a" /listShort="yvbJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" misc_feature 3100292..3100311 /Source="Nicolas_upshift_promotors" /id="U2672" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.679320679320679" /psig="0.994005994005994" /xcortree=3040 /SigmaFactorBS="aaaataacatgactttcctcctattctactaatttgataaca tttactgcttttcATATTTTATAATAAAACAGAatgaaattgggaacgaatgaaaaaa t" /listShort="yvbK" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3100297 /Source="Nicolas_upshifts" /id="U2672" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.679320679320679" /psig="0.994005994005994" /xcortree=3040 /SigmaFactorBS="aaaataacatgactttcctcctattctactaatttgataaca tttactgcttttcATATTTTATAATAAAACAGAatgaaattgggaacgaatgaaaaaa t" /listShort="yvbK" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3100301) /Source="Nicolas_upshifts" /id="U2673" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.546453546453546" /psig="0.995004995004995" /xcortree=2319 /SigmaFactorBS="cctttttagtctgatagacatttaattttttcattcgttccc aatttcattctgTTTTATTATAAAATATGAAAagcagtaaatgttatcaaattagtag a" /listShort="yvbJ" /GFF_Attribute="listLong" /label="upshifts" CDS 3100366..3100833 /gene="yvbK" /locus_tag="BSU_33890" /old_locus_tag="BSU33890" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acyltransferase" /protein_id="NP_391269.1" /db_xref="EnsemblGenomes-Gn:BSU33890" /db_xref="EnsemblGenomes-Tr:CAB15394" /db_xref="GOA:O32248" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="PDB:1YVK" /db_xref="SubtiList:BG14084" /db_xref="UniProtKB/Swiss-Prot:O32248" /translation="MNMQKLRIELGEETNDELYDLLLLADPSKDIVDEYLERGECYTA WAGDELAGVYVLLKTRPQTVEIVNIAVKESLQKKGFGKQLVLDAIEKAKKLGADTIEI GTGNSSIHQLSLYQKCGFRIQAIDHDFFLRHYDEDIFENGIQCRDMVRLYLDL*" /label="yvbK CDS" gene 3100366..3100833 /gene="yvbK" /locus_tag="BSU_33890" /old_locus_tag="BSU33890" /label="yvbK gene" downshifts 3100830 /Source="Nicolas_upshifts" /id="D1763" /incds=0 /nref=199 /ntot=250 /MaxReadThrough="1.84358" /MaxDrop="5.3321" /score="15.9040274" /energy="-13.3" /TU="U2672" /idTUdmin="U2672" /TUdmin="-23" /isTUend="FALSE" /label="downshifts" CDS complement(3100878..3102170) /gene="eno" /locus_tag="BSU_33900" /old_locus_tag="BSU33900" /EC_number="4.2.1.11" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8021172, 9588797, 12682299, 15301535, 19193632, 19215769, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8021172, 9588797, 12682299, 15301535, 19193632, 19215769, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enolase" /protein_id="NP_391270.1" /db_xref="EnsemblGenomes-Gn:BSU33900" /db_xref="EnsemblGenomes-Tr:CAB15395" /db_xref="GOA:P37869" /db_xref="InterPro:IPR000941" /db_xref="InterPro:IPR020809" /db_xref="InterPro:IPR020810" /db_xref="InterPro:IPR020811" /db_xref="InterPro:IPR029017" /db_xref="InterPro:IPR034390" /db_xref="InterPro:IPR036849" /db_xref="PDB:4A3R" /db_xref="SubtiList:BG10899" /db_xref="UniProtKB/Swiss-Prot:P37869" /translation="MPYIVDVYAREVLDSRGNPTVEVEVYTETGAFGRALVPSGASTG EYEAVELRDGDKDRYLGKGVLTAVNNVNEIIAPELLGFDVTEQNAIDQLLIELDGTEN KGKLGANAILGVSMACARAAADFLQIPLYQYLGGFNSKTLPVPMMNIVNGGEHADNNV DIQEFMIMPVGAPNFREALRMGAQIFHSLKSVLSAKGLNTAVGDEGGFAPNLGSNEEA LQTIVEAIEKAGFKPGEEVKLAMDAASSEFYNKEDGKYHLSGEGVVKTSAEMVDWYEE LVSKYPIISIEDGLDENDWEGHKLLTERLGKKVQLVGDDLFVTNTKKLSEGIKNGVGN SILIKVNQIGTLTETFDAIEMAKRAGYTAVISHRSGETEDSTIADIAVATNAGQIKTG APSRTDRVAKYNQLLRIEDQLAETAQYHGINSFYNLNK*" /label="eno CDS" gene complement(3100878..3102170) /gene="eno" /locus_tag="BSU_33900" /old_locus_tag="BSU33900" /label="eno gene" downshifts complement(3100888) /Source="Nicolas_upshifts" /id="D1764" /incds=0 /nref=254 /ntot=269 /MaxReadThrough="2.21852" /MaxDrop="9.34136" /score="29.8674712" /energy="-15" /TU="NA" /idTUdmin="U2674" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS complement(3102200..3103735) /gene="pgm" /locus_tag="BSU_33910" /old_locus_tag="BSU33910" /EC_number="5.4.2.12" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9830105, 10869096, 12682299, 19193632, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9830105, 10869096, 12682299, 19193632, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoglycerate mutase" /protein_id="NP_391271.1" /db_xref="EnsemblGenomes-Gn:BSU33910" /db_xref="EnsemblGenomes-Tr:CAB15396" /db_xref="GOA:P39773" /db_xref="InterPro:IPR005995" /db_xref="InterPro:IPR006124" /db_xref="InterPro:IPR011258" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="InterPro:IPR036646" /db_xref="SubtiList:BG10898" /db_xref="UniProtKB/Swiss-Prot:P39773" /translation="MSKKPAALIILDGFGLRNETVGNAVALAKKPNFDRYWNQYPHQT LTASGEAVGLPEGQMGNSEVGHLNIGAGRIVYQSLTRVNVAIREGEFERNQTFLDAIS NAKENNKALHLFGLLSDGGVHSHINHLFALLKLAKKEGLTKVYIHGFLDGRDVGPQTA KTYINQLNDQIKEIGVGEIASISGRYYSMDRDKRWDRVEKAYRAMAYGEGPSYRSALD VVDDSYANGIYDEFVIPSVITKENGEPVAKIQDGDSVIFYNFRPDRAIQISNTFTNKD FRDFDRGENYPKNLYFVCLTHFSETVDGYVAFKPINLDNTVGEVLSQHGLKQLRIAET EKYPHVTFFMSGGREAEFPGEERILINSPKVATYDLKPEMSAYEVKDALVKEIEADKH DAIILNFANPDMVGHSGMVEPTIKAIEAVDECLGEVVDAILAKGGHAIITADHGNADI LITESGEPHTAHTTNPVPVIVTKEGITLREGGILGDLAPTLLDLLGVEKPKEMTGTSL IQK*" /label="pgm CDS" gene complement(3102200..3103735) /gene="pgm" /locus_tag="BSU_33910" /old_locus_tag="BSU33910" /label="pgm gene" CDS complement(3103728..3104489) /gene="tpiA" /locus_tag="BSU_33920" /old_locus_tag="BSU33920" /EC_number="5.3.1.1" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8021172, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="triose phosphate isomerase" /protein_id="NP_391272.1" /db_xref="EnsemblGenomes-Gn:BSU33920" /db_xref="EnsemblGenomes-Tr:CAB15397" /db_xref="GOA:P27876" /db_xref="InterPro:IPR000652" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR020861" /db_xref="InterPro:IPR022896" /db_xref="InterPro:IPR035990" /db_xref="SubtiList:BG10897" /db_xref="UniProtKB/Swiss-Prot:P27876" /translation="MRKPIIAGNWKMNKTLGEAVSFVEEVKSSIPAADKAEAVVCAPA LFLEKLASAVKGTDLKVGAQNMHFEESGAFTGEISPVALKDLGVDYCVIGHSERREMF AETDETVNKKAHAAFKHGIVPIICVGETLEEREAGKTNDLVADQVKKGLAGLSEEQVA ASVIAYEPIWAIGTGKSSTAKDANDVCAHIRKTVAESFSQEAADKLRIQYGGSVKPAN IKEYMAESDIDGALVGGASLEPQSFVQLLEEGQYE*" /label="tpiA CDS" gene complement(3103728..3104489) /gene="tpiA" /locus_tag="BSU_33920" /old_locus_tag="BSU33920" /label="tpiA gene" CDS complement(3104520..3105704) /gene="pgk" /locus_tag="BSU_33930" /old_locus_tag="BSU33930" /EC_number="2.7.2.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10559176, 12682299, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10559176, 12682299, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoglycerate kinase" /protein_id="NP_391273.1" /db_xref="EnsemblGenomes-Gn:BSU33930" /db_xref="EnsemblGenomes-Tr:CAB15398" /db_xref="GOA:P40924" /db_xref="InterPro:IPR001576" /db_xref="InterPro:IPR015824" /db_xref="InterPro:IPR015911" /db_xref="InterPro:IPR036043" /db_xref="SubtiList:BG11062" /db_xref="UniProtKB/Swiss-Prot:P40924" /translation="MNKKTLKDIDVKGKVVFCRVDFNVPMKDGEVTDDTRIRAALPTI KHLADQGAKVLLASHLGRPKGEVVEELRLTPVAARLGELLGKEVKKADEAYGDAVKAQ ISEMKDGDVLVLENVRFYPGEEKNDPELAKAFAELADVYVNDAFGAAHRAHASTAGIA EHLPAVAGFLMEKELDVLGKAVSNPDRPFTAIIGGAKVKDKIGVIESLLDKVDNLIIG GGLAYTFVKALGYEVGKSLLEEDKIELAKSFMDRAKEKGVNFYMPEDVLVADDFSNDA NVKIVPISEIPSDLEAIDIGTKTRETYADVIKNSKLVVWNGPMGVFEIDLFAQGTKAV AEALAEAKDTYSVIGGGDSAAAVEKFGLADKMSHISTGGGASLEFMEGKELPGVAALN DK*" /label="pgk CDS" gene complement(3104520..3105704) /gene="pgk" /locus_tag="BSU_33930" /old_locus_tag="BSU33930" /label="pgk gene" S_feature complement(3105705..3105945) /Source="Nicolas_S_feature" /locus_tag="new_3481382_3481622_c" /HighExp="Lbstat, Lbtran, C90, LBGtran, LBGexp, G150, M40t45, LPhT, M0t45, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-, SigA, SigK" /TUshortPSig="0.979, 0.136, 0.993, 0.902" /TUlongSig="NA" /TUlongPSig="NA" /label="S1300" upshifts complement(3105945) /Source="Nicolas_upshifts" /id="U2674" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.93906093906094" /psig="0.97902097902098" /xcortree=2685 /SigmaFactorBS="ggacctgACTTGgttctttcgaatagaAGCGCTATAATGAAA GCGGAcaagggaaggggacggactccctttccctttttccatgaagaccggctttcag a" /listShort="S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3105947..3106020) /Source="Nicolas_S_feature" /locus_tag="new_3481624_3481697_c" /HighExp="C90, LBGtran, Lbstat, LBGexp, Lbtran, G150, M40t45, Etha, ferm, Gly" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigK" /TUshortPSig="0.136, 0.993, 0.902" /TUlongSig="NA" /TUlongPSig="NA" /label="S1301" promotor_-10 complement(3105959..3105978) /Source="Nicolas_upshift_promotors" /id="U2674" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.93906093906094" /psig="0.97902097902098" /xcortree=2685 /SigmaFactorBS="ggacctgACTTGgttctttcgaatagaAGCGCTATAATGAAA GCGGAcaagggaaggggacggactccctttccctttttccatgaagaccggctttcag a" /listShort="S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3105994..3105998) /Source="Nicolas_upshift_promotors" /id="U2674" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.93906093906094" /psig="0.97902097902098" /xcortree=2685 /SigmaFactorBS="ggacctgACTTGgttctttcgaatagaAGCGCTATAATGAAA GCGGAcaagggaaggggacggactccctttccctttttccatgaagaccggctttcag a" /listShort="S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3106021..3107028) /gene="gapA" /locus_tag="BSU_33940" /old_locus_tag="BSU33940" /EC_number="1.2.1.12" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9588797, 10799476, 12123463, 12634343, 17142398, 27449348, 28760849" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9588797, 10799476, 12123463, 12634343, 17142398, 27449348, 28760849; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glyceraldehyde-3-phosphate dehydrogenase (NAD-dependent, glycolytic)" /protein_id="NP_391274.1" /db_xref="EnsemblGenomes-Gn:BSU33940" /db_xref="EnsemblGenomes-Tr:CAB15399" /db_xref="GOA:P09124" /db_xref="InterPro:IPR006424" /db_xref="InterPro:IPR020828" /db_xref="InterPro:IPR020829" /db_xref="InterPro:IPR020830" /db_xref="InterPro:IPR020831" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10827" /db_xref="UniProtKB/Swiss-Prot:P09124" /translation="MAVKVGINGFGRIGRNVFRAALNNPEVEVVAVNDLTDANMLAHL LQYDSVHGKLDAEVSVDGNNLVVNGKTIEVSAERDPAKLSWGKQGVEIVVESTGFFTK RADAAKHLEAGAKKVIISAPANEEDITIVMGVNEDKYDAANHDVISNASCTTNCLAPF AKVLNDKFGIKRGMMTTVHSYTNDQQILDLPHKDYRRARAAAENIIPTSTGAAKAVSL VLPELKGKLNGGAMRVPTPNVSLVDLVAELNQEVTAEEVNAALKEAAEGDLKGILGYS EEPLVSGDYNGNKNSSTIDALSTMVMEGSMVKVISWYDNESGYSNRVVDLAAYIAKKG L*" /label="gapA CDS" gene complement(3106021..3107028) /gene="gapA" /locus_tag="BSU_33940" /old_locus_tag="BSU33940" /label="gapA gene" promotor_-35 3106947..3106950 /Source="Nicolas_upshift_promotors" /id="U2675" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.001998001998002" /xcortree=75 /SigmaFactorBS="catgttagcatctgttaaatcgttaaccgctactacctCAAC ttcaggattgtttaatGCTgcgcggaatacgttacgtccaatacgaccaaaaccgtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3106967..3106969 /Source="Nicolas_upshift_promotors" /id="U2675" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.001998001998002" /xcortree=75 /SigmaFactorBS="catgttagcatctgttaaatcgttaaccgctactacctCAAC ttcaggattgtttaatGCTgcgcggaatacgttacgtccaatacgaccaaaaccgtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3106969 /Source="Nicolas_upshifts" /id="U2675" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.001998001998002" /xcortree=75 /SigmaFactorBS="catgttagcatctgttaaatcgttaaccgctactacctCAAC ttcaggattgtttaatGCTgcgcggaatacgttacgtccaatacgaccaaaaccgtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3107075..3108097) /gene="cggR" /locus_tag="BSU_33950" /old_locus_tag="BSU33950" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11489127, 12622823, 17142398, 17293407, 18052209, 18554327" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11489127, 12622823, 17142398, 17293407, 18052209, 18554327; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of gapA" /protein_id="NP_391275.1" /db_xref="EnsemblGenomes-Gn:BSU33950" /db_xref="EnsemblGenomes-Tr:CAB15400" /db_xref="GOA:O32253" /db_xref="InterPro:IPR007324" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2OKG" /db_xref="PDB:3BXE" /db_xref="PDB:3BXF" /db_xref="PDB:3BXG" /db_xref="PDB:3BXH" /db_xref="SubtiList:BG14085" /db_xref="UniProtKB/Swiss-Prot:O32253" /translation="MNQLIQAQKKLLPDLLLVMQKRFEILQYIRLTEPIGRRSLSASL GISERVLRGEVQFLKEQNLVDIKTNGMTLTEEGYELLSVLEDTMKDVLGLTLLEKTLK ERLNLKDAIIVSGDSDQSPWVKKEMGRAAVACMKKRFSGKNIVAVTGGTTIEAVAEMM TPDSKNRELLFVPARGGLGEDVKNQANTICAHMAEKASGTYRLLFVPGQLSQGAYSSI IEEPSVKEVLNTIKSASMLVHGIGEAKTMAQRRNTPLEDLKKIDDNDAVTEAFGYYFN ADGEVVHKVHSVGMQLDDIDAIPDIIAVAGGSSKAEAIEAYFKKPRNTVLVTDEGAAK KLLRDE*" /label="cggR CDS" gene complement(3107075..3108097) /gene="cggR" /locus_tag="BSU_33950" /old_locus_tag="BSU33950" /label="cggR gene" upshifts complement(3107091) /Source="Nicolas_upshifts" /id="U2676" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.313686313686314" /psig="0.135864135864136" /xcortree=2684 /SigmaFactorBS="cttactttaaaaagccacgcaacacggttctCGtcacagacg aaggagccgcAaagaagttattaagggatgaataatccctcaatataaatatctctca c" /listShort="gapA, S1301, S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3107119..3107120) /Source="Nicolas_upshift_promotors" /id="U2676" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.313686313686314" /psig="0.135864135864136" /xcortree=2684 /SigmaFactorBS="cttactttaaaaagccacgcaacacggttctCGtcacagacg aaggagccgcAaagaagttattaagggatgaataatccctcaatataaatatctctca c" /listShort="gapA, S1301, S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3108098..3108209) /Source="Nicolas_S_feature" /locus_tag="new_3483775_3483886_c" /HighExp="LPhT, C90, LBGtran, Heat, BI, LBGexp, Lbstat, Sw, Lbexp, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.993, 0.902" /TUlongSig="NA" /TUlongPSig="NA" /label="S1302" downshifts 3108135 /Source="Nicolas_upshifts" /id="D1765" /incds=0 /nref=3 /ntot=50 /MaxReadThrough="4.48989" /MaxDrop="5.24842" /score="-9.71393179" /energy="-11.8" /TU="NA" /idTUdmin="U2675" /TUdmin=1078 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3108190..3108209) /Source="Nicolas_upshift_promotors" /id="U2677" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.561438561438561" /psig="0.993006993006993" /xcortree=5 /SigmaFactorBS="tgaaaactctgcgaatattgtcgatgaattggctcttaaCAG TTGAAtaaacaattccacCCTGTTAAAATAATTAAAGAaagcagaaatgatttttttt g" /listShort="S1302, cggR, gapA, S1301, S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3108209) /Source="Nicolas_upshifts" /id="U2677" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.561438561438561" /psig="0.993006993006993" /xcortree=5 /SigmaFactorBS="tgaaaactctgcgaatattgtcgatgaattggctcttaaCAG TTGAAtaaacaattccacCCTGTTAAAATAATTAAAGAaagcagaaatgatttttttt g" /listShort="S1302, cggR, gapA, S1301, S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3108211..3108321) /Source="Nicolas_S_feature" /locus_tag="new_3483888_3483998_c" /HighExp="S8, S6, S7, BT, B36, S5, S4, S3, B60, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.902" /TUlongSig="NA" /TUlongPSig="NA" /label="S1303" promotor_-35 complement(3108223..3108230) /Source="Nicolas_upshift_promotors" /id="U2677" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.561438561438561" /psig="0.993006993006993" /xcortree=5 /SigmaFactorBS="tgaaaactctgcgaatattgtcgatgaattggctcttaaCAG TTGAAtaaacaattccacCCTGTTAAAATAATTAAAGAaagcagaaatgatttttttt g" /listShort="S1302, cggR, gapA, S1301, S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3108304..3108323) /Source="Nicolas_upshift_promotors" /id="U2678" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.902097902097902" /psig="0.902097902097902" /xcortree=1316 /SigmaFactorBS="acagccctttctacgggaagggctgtttatattgGGATGCAC CAtttggcgctttcTGTATAAGATAAAGATATATaggataaaatattgctggataaaa c" /listShort="S1303, S1302, cggR, gapA, S1301, S1300" /listLong="pgk, tpiA, pgm, eno" /label="promotor_-10" upshifts complement(3108319) /Source="Nicolas_upshifts" /id="U2678" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.902097902097902" /psig="0.902097902097902" /xcortree=1316 /SigmaFactorBS="acagccctttctacgggaagggctgtttatattgGGATGCAC CAtttggcgctttcTGTATAAGATAAAGATATATaggataaaatattgctggataaaa c" /listShort="S1303, S1302, cggR, gapA, S1301, S1300" /listLong="pgk, tpiA, pgm, eno" /label="upshifts" promotor_-35 complement(3108336..3108345) /Source="Nicolas_upshift_promotors" /id="U2678" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.902097902097902" /psig="0.902097902097902" /xcortree=1316 /SigmaFactorBS="acagccctttctacgggaagggctgtttatattgGGATGCAC CAtttggcgctttcTGTATAAGATAAAGATATATaggataaaatattgctggataaaa c" /listShort="S1303, S1302, cggR, gapA, S1301, S1300" /listLong="pgk, tpiA, pgm, eno" /label="promotor_-35" CDS complement(3108395..3109789) /gene="araE" /locus_tag="BSU_33960" /old_locus_tag="BSU33960" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9620981, 10417639, 15849754, 16850406, 20693325" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9620981, 10417639, 15849754, 16850406, 20693325; Product type t : transporter" /codon_start=1 /transl_table=11 /product="arabinose-related compounds permease" /protein_id="NP_391276.1" /db_xref="EnsemblGenomes-Gn:BSU33960" /db_xref="EnsemblGenomes-Tr:CAB15401" /db_xref="GOA:P96710" /db_xref="InterPro:IPR003663" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11907" /db_xref="UniProtKB/Swiss-Prot:P96710" /translation="MKNTPTQLEPNVPVTRSHSMGFVILISCAAGLGGLLYGYDTAVI SGAIGFLKDLYSLSPFMEGLVISSIMIGGVVGVGISGFLSDRFGRRKILMTAALLFAI SAIVSALSQDVSTLIIARIIGGLGIGMGSSLSVTYITEAAPPAIRGSLSSLYQLFTIL GISATYFINLAVQRSGTYEWGVHTGWRWMLAYGMVPSVIFFLVLLVVPESPRWLAKAG KTNEALKILTRINGETVAKEELKNIENSLKIEQMGSLSQLFKPGLRKALVIGILLALF NQVIGMNAITYYGPEIFKMMGFGQNAGFVTTCIVGVVEVIFTVIAVLLIDKVGRKKLM SIGSAFMAIFMILIGTSFYFELTSGIMMIVLILGFVAAFCVSVGPITWIMISEIFPNH LRARAAGIATIFLWGANWAIGQFVPMMIDSFGLAYTFWIFAVINILCFLFVVTICPET KNKSLEEIEKLWIK*" /label="araE CDS" gene complement(3108395..3109789) /gene="araE" /locus_tag="BSU_33960" /old_locus_tag="BSU33960" /label="araE gene" downshifts complement(3108409) /Source="Nicolas_upshifts" /id="D1766" /incds=0 /nref=1 /ntot=23 /MaxReadThrough="1.15614" /MaxDrop="3.28809" /score="1.06999853" /energy="-14.6" /TU="NA" /idTUdmin="U2679" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3109888..3109907) /Source="Nicolas_upshift_promotors" /id="U2679" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=348 /SigmaFactorBS="tttcagtatatcacagcgttctttgtaagaaaaCATTGACAg aaaatgcaaacaaGATTATTCTATATTTGTACGtactaattaaatgtaattttcgtta a" /listShort="araE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3109902) /Source="Nicolas_upshifts" /id="U2679" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=348 /SigmaFactorBS="tttcagtatatcacagcgttctttgtaagaaaaCATTGACAg aaaatgcaaacaaGATTATTCTATATTTGTACGtactaattaaatgtaattttcgtta a" /listShort="araE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3109922..3109929) /Source="Nicolas_upshift_promotors" /id="U2679" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=348 /SigmaFactorBS="tttcagtatatcacagcgttctttgtaagaaaaCATTGACAg aaaatgcaaacaaGATTATTCTATATTTGTACGtactaattaaatgtaattttcgtta a" /listShort="araE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3109929..3109936 /Source="Nicolas_upshift_promotors" /id="U2680" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.47052947052947" /psig=1 /xcortree=2310 /SigmaFactorBS="tatagaataatcttgtttgcattttctgtcaatGTTTTCTTa caaagaacgctgTGATATACTGAAATTTGTCCgtatacattttggaggaatggatatg t" /listShort="araR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3109950..3109969 /Source="Nicolas_upshift_promotors" /id="U2680" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.47052947052947" /psig=1 /xcortree=2310 /SigmaFactorBS="tatagaataatcttgtttgcattttctgtcaatGTTTTCTTa caaagaacgctgTGATATACTGAAATTTGTCCgtatacattttggaggaatggatatg t" /listShort="araR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3109956 /Source="Nicolas_upshifts" /id="U2680" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.47052947052947" /psig=1 /xcortree=2310 /SigmaFactorBS="tatagaataatcttgtttgcattttctgtcaatGTTTTCTTa caaagaacgctgTGATATACTGAAATTTGTCCgtatacattttggaggaatggatatg t" /listShort="araR" /GFF_Attribute="listLong" /label="upshifts" CDS 3109993..3111081 /gene="araR" /locus_tag="BSU_33970" /old_locus_tag="BSU33970" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10417639, 11418559, 12949161, 14973026, 16585763, 17617643, 22281747, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10417639, 11418559, 12949161, 14973026, 16585763, 17617643, 22281747, 26735940; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of the ara regulon (LacI family)" /protein_id="NP_391277.2" /db_xref="EnsemblGenomes-Gn:BSU33970" /db_xref="EnsemblGenomes-Tr:CAB15402" /db_xref="GOA:P96711" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR028082" /db_xref="InterPro:IPR033532" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:3TB6" /db_xref="PDB:4EGY" /db_xref="PDB:4EGZ" /db_xref="PDB:4H0E" /db_xref="PDB:5D4R" /db_xref="PDB:5D4S" /db_xref="SubtiList:BG11913" /db_xref="UniProtKB/Swiss-Prot:P96711" /translation="MLPKYAQVKEEISSWINQGKILPDQKIPTENELMQQFGVSRHTI RKAIGDLVSQGLLYSVQGGGTFVASRSAKSALHSNKTIGVLTTYISDYIFPSIIRGIE SYLSEQGYSMLLTSTNNNPDNERRGLENLLSQHIDGLIVEPTKSALQTPNIGYYLNLE KNGIPFAMINASYAELAAPSFTLDDVKGGMMAAEHLLSLGHTHMMGIFKADDTQGVKR MNGFIQAHRERELFPSPDMIVTFTTEEKESKLLEKVKATLEKNSKHMPTAILCYNDEI ALKVIDMLREMDLKVPEDMSIVGYDDSHFAQISEVKLTSVKHPKSVLGKAAAKYVIDC LEHKKPKQEDVIFEPELIIRQSARKLNE*" /label="araR CDS" gene 3109993..3111081 /gene="araR" /locus_tag="BSU_33970" /old_locus_tag="BSU33970" /label="araR gene" downshifts 3111061 /Source="Nicolas_upshifts" /id="D1767" /incds=0 /nref=202 /ntot=247 /MaxReadThrough="1.17419" /MaxDrop="4.76041" /score="20.2322165" /energy="-13.6" /TU="NA" /idTUdmin="U2680" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3111130..3112140) /gene="yvbT" /locus_tag="BSU_33980" /old_locus_tag="BSU33980" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9836433; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative alkanal monooxygenase" /protein_id="NP_391278.1" /db_xref="EnsemblGenomes-Gn:BSU33980" /db_xref="EnsemblGenomes-Tr:CAB15403" /db_xref="GOA:O32254" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR019949" /db_xref="InterPro:IPR036661" /db_xref="SubtiList:BG14086" /db_xref="UniProtKB/Swiss-Prot:O32254" /translation="MSNNQRKDTLLSVLNLSPVVQGGTIAESFRNSMDLARRAEEWGY HRYWLAEHHNIEGVASSATAVLIGHIAGGTKKIRVGSGGIMLPNHSSLVIAEQFGTLE TLYPGRIDLGLGRAPGTDQLTARALRRNINSGEDFPEQLEELRNYFKPSGNVRNQVRA IPGEGIDVPIWLLGSSGFSARLAGELGLPFAFAAHFSPANTVPALELYRNSFTPSDVL DEPYAMVGVTIIAADTNEKAQHLATSHYQRFLDLVRGTPNQLKPPVEDMDQIWSPYEK AMVNEQLSSTIVGGPEEVKAKLEDFVKTTQADEIMVNSETFEHADRMRSFEIIADVWK NR*" /label="yvbT CDS" gene complement(3111130..3112140) /gene="yvbT" /locus_tag="BSU_33980" /old_locus_tag="BSU33980" /label="yvbT gene" downshifts complement(3111137) /Source="Nicolas_upshifts" /id="D1768" /incds=0 /nref=200 /ntot=252 /MaxReadThrough="1.53983" /MaxDrop="7.63266" /score="27.2032847" /energy="-14.2" /TU="NA" /idTUdmin="U2681" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3112141..3112218) /Source="Nicolas_S_feature" /locus_tag="new_3487818_3487895_c" /HighExp="dia5, dia15, Diami, H2O2, Salt, Paraq, G180, Etha, G150, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1304" promotor_-10 complement(3112208..3112227) /Source="Nicolas_upshift_promotors" /id="U2681" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.912087912087912" /psig=1 /xcortree=2040 /SigmaFactorBS="ttatattgttcgaatttcatcgaatcaaatTCTTTTATtcct gaatgcagtTGTGTTATGGTGTGATAGAAgttctttcaatcatgacctgacagctttg g" /listShort="S1304, yvbT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3112218) /Source="Nicolas_upshifts" /id="U2681" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.912087912087912" /psig=1 /xcortree=2040 /SigmaFactorBS="ttatattgttcgaatttcatcgaatcaaatTCTTTTATtcct gaatgcagtTGTGTTATGGTGTGATAGAAgttctttcaatcatgacctgacagctttg g" /listShort="S1304, yvbT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3112241..3112248) /Source="Nicolas_upshift_promotors" /id="U2681" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.912087912087912" /psig=1 /xcortree=2040 /SigmaFactorBS="ttatattgttcgaatttcatcgaatcaaatTCTTTTATtcct gaatgcagtTGTGTTATGGTGTGATAGAAgttctttcaatcatgacctgacagctttg g" /listShort="S1304, yvbT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3112297..3113175) /gene="yvbU" /locus_tag="BSU_33990" /old_locus_tag="BSU33990" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (LysR family)" /protein_id="NP_391279.1" /db_xref="EnsemblGenomes-Gn:BSU33990" /db_xref="EnsemblGenomes-Tr:CAB15404" /db_xref="GOA:O32255" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG14087" /db_xref="UniProtKB/Swiss-Prot:O32255" /translation="MTITQLKVFVKIAETGSFTKAGQALNMTQPAVSHAISAIEAELD VKLIIRDRRNGLMLTDTGKQILVHIREVLKGIEKVEQVAAAEKGLELGTIHIGTFSTA SAYFMPKLISEFKQKYPKLELVLHEGTVNEVKEWLHTRMIDVGILLYPTEEMEYIHLK KDKMAVVLRDDHPLASHSAITLKDLDHEPMIVCDGGYESPFIDMFRQAGATLHPAFTV YNINTSISMIREGLGLAILSEMSMSGMPLPEHVVTRELDPQVYRDVQLAVPSLKEASL AAKLFIEMAKELFGAE*" /label="yvbU CDS" gene complement(3112297..3113175) /gene="yvbU" /locus_tag="BSU_33990" /old_locus_tag="BSU33990" /label="yvbU gene" promotor_-35 3112833..3112839 /Source="Nicolas_upshift_promotors" /id="U2682" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.72927072927073" /psig="0.72927072927073" /xcortree=1209 /SigmaFactorBS="acgagctcaagtttcggatatttttgttTAAATTCactgatc agcttcgGCATAAAATAAGccgaggcagttgagaatgtgccgatatggatcgttccca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3112854..3112865 /Source="Nicolas_upshift_promotors" /id="U2682" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.72927072927073" /psig="0.72927072927073" /xcortree=1209 /SigmaFactorBS="acgagctcaagtttcggatatttttgttTAAATTCactgatc agcttcgGCATAAAATAAGccgaggcagttgagaatgtgccgatatggatcgttccca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3112865 /Source="Nicolas_upshifts" /id="U2682" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.72927072927073" /psig="0.72927072927073" /xcortree=1209 /SigmaFactorBS="acgagctcaagtttcggatatttttgttTAAATTCactgatc agcttcgGCATAAAATAAGccgaggcagttgagaatgtgccgatatggatcgttccca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3113209..3113216 /Source="Nicolas_upshift_promotors" /id="U2684" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2018 /SigmaFactorBS="tcataacaatttacttatgctccttataaaaaagattCATTT TATttatcttatgttcTACCGTATCATATGATGGAAaagttctacaaggagtgaatga a" /listShort="cyeB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3113222..3113241) /Source="Nicolas_upshift_promotors" /id="U2683" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.732267732267732" /psig=1 /xcortree=1895 /SigmaFactorBS="ggagctgcttcattgttcattcactcctTGTAGaacttttcc atcaTATGATACGGTAGAACATAAgataaataaaatgaatcttttttataaggagcat a" /listShort="yvbU" /listLong="S1304, yvbT" /label="promotor_-10" upshifts complement(3113227) /Source="Nicolas_upshifts" /id="U2683" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.732267732267732" /psig=1 /xcortree=1895 /SigmaFactorBS="ggagctgcttcattgttcattcactcctTGTAGaacttttcc atcaTATGATACGGTAGAACATAAgataaataaaatgaatcttttttataaggagcat a" /listShort="yvbU" /listLong="S1304, yvbT" /label="upshifts" promotor_-10 3113230..3113249 /Source="Nicolas_upshift_promotors" /id="U2684" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2018 /SigmaFactorBS="tcataacaatttacttatgctccttataaaaaagattCATTT TATttatcttatgttcTACCGTATCATATGATGGAAaagttctacaaggagtgaatga a" /listShort="cyeB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3113232 /Source="Nicolas_upshifts" /id="U2684" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2018 /SigmaFactorBS="tcataacaatttacttatgctccttataaaaaagattCATTT TATttatcttatgttcTACCGTATCATATGATGGAAaagttctacaaggagtgaatga a" /listShort="cyeB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3113255..3113259) /Source="Nicolas_upshift_promotors" /id="U2683" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.732267732267732" /psig=1 /xcortree=1895 /SigmaFactorBS="ggagctgcttcattgttcattcactcctTGTAGaacttttcc atcaTATGATACGGTAGAACATAAgataaataaaatgaatcttttttataaggagcat a" /listShort="yvbU" /listLong="S1304, yvbT" /label="promotor_-35" CDS 3113275..3114192 /gene="cyeB" /locus_tag="BSU_34000" /old_locus_tag="BSU34000" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10844694, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="cysteine and O-acetylserine efflux permease" /protein_id="NP_391280.1" /db_xref="EnsemblGenomes-Gn:BSU34000" /db_xref="EnsemblGenomes-Tr:CAB15405" /db_xref="GOA:O32256" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG14088" /db_xref="UniProtKB/Swiss-Prot:O32256" /translation="MKQLPKTRTALLLAFLVIMWGVNWPLSKAALAYSPPLLFAGIRT LIGGLLLVIVALPRIHKLRLKETWPIYLVSALLNITLFYGLQTIGLNYLPAGLFSAIV FFQPVLMGVFSWLWLGESMFVMKVIGLILGFAGVAVISAAGFGGHISVIGVLLALGSA VSWALGTVYMKKTGSRVDSIWMVALQLTIGSVFLLISGFWTESFSAIQWTAPFITSLL FISVFVIALGWLVFFTLVGSGEASKVASYTFLIPLISIVASSIFLHEPLTLSLLAGLL LIVTSICLVNTKSKAQKAAAIGINEKAAQ*" /label="cyeB CDS" gene 3113275..3114192 /gene="cyeB" /locus_tag="BSU_34000" /old_locus_tag="BSU34000" /label="cyeB gene" downshifts 3114181 /Source="Nicolas_upshifts" /id="D1769" /incds=0 /nref=6 /ntot=15 /MaxReadThrough="2.97475" /MaxDrop="3.548" /score="22.9557936" /energy="-19.2" /TU="NA" /idTUdmin="U2684" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(3114233..3115576) /gene="yvbW" /locus_tag="BSU_34010" /old_locus_tag="BSU34010" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 19258532, 25645558; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative leucine permease" /protein_id="NP_391281.1" /db_xref="EnsemblGenomes-Gn:BSU34010" /db_xref="EnsemblGenomes-Tr:CAB15406" /db_xref="GOA:O32257" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG14089" /db_xref="UniProtKB/Swiss-Prot:O32257" /translation="MKNDNQTLKRTMTSRHIMMMALGGAIGAGLFKGSSSAIDVAGPS VIIAYLLGGIILLFIMQGLAEMAVRNRNARTFRDLVQQVLGNYAAYFLDWIYWKMWVL NIAAEAVVAAIFIQYWLPGCPIWVLALGISLIVTIVNLLSVKIFAETEYWLAMIKITV IIIFIILGLLLLFVSFGDHTASGFSNLTDHGGFFPHGGTGLITAMLVVIYSYGGTEII GVTLAETKNPEKVVPKAVRSTLTRIVAFYLLPFFIIVSLIPWNQVNSVPESPFVMVFK MVGIPGADHIMNAVILLAIISSMNSGLYGSSRILYTQASDGRLPKVFSKLSSKNVPMF AILMCTSSLYIGVLISLFAGSQTFNYLMGSLGYTVLFIWLIIGFAHLKSRKQQTETPA YYVKWFPYTTWFAIVALLAILIGVIMTTSIVITGITAAIYLLITVAYLVKGRKHQ*" /label="yvbW CDS" gene complement(3114233..3115576) /gene="yvbW" /locus_tag="BSU_34010" /old_locus_tag="BSU34010" /label="yvbW gene" misc_RNA complement(3115645..3115880) /gene="tboX" /locus_tag="BSU_misc_RNA_56" /product="T-box riboswitch controlling synthesis of an amino acid transporter" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 18625071, 19258532; Product type n: RNA" /function="16.3: Control" /label="tboX RNA" gene complement(3115645..3115880) /gene="tboX" /locus_tag="BSU_misc_RNA_56" /label="tboX gene" downshifts complement(3115779) /Source="Nicolas_upshifts" /id="D1770" /incds=1 /nref=1 /ntot=104 /MaxReadThrough="5.18182" /MaxDrop="2.29735" /score="33.4262209" /energy="-24.4" /TU="U2685,U2689" /idTUdmin="U2689" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" S_feature complement(3115881..3115977) /Source="Nicolas_S_feature" /locus_tag="new_3491558_3491654_c" /HighExp="Cold, GM 120, C30, GM 90, C90, GM 15, GM 10, GM 25, HPh, GM 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA" /TUshortPSig="1, 0.994" /TUlongSig="SigA" /TUlongPSig=1 /label="S1305" CDS complement(3115978..3117012) /gene="yvbX" /locus_tag="BSU_34020" /old_locus_tag="BSU34020" /function="16.5: Explore" /function="16.13: Shape" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12177332; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative epimerase modification of peptidoglycan" /protein_id="NP_391282.1" /db_xref="EnsemblGenomes-Gn:BSU34020" /db_xref="EnsemblGenomes-Tr:CAB15407" /db_xref="GOA:O32258" /db_xref="InterPro:IPR001223" /db_xref="InterPro:IPR011583" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG14090" /db_xref="UniProtKB/Swiss-Prot:O32258" /translation="MKKWLIIAVSLAIAIVLFMYTKGEAKAAGMTVGYTTGDTASYNS LTKYHTYMNAIATDTFAFEKNGQIIGDAPTKQLTYAKKKKIKTWAVISNYNDAIYDFD GDLASRVMSNKTAKKRFTDQLITLAKKHSYYGINIDFEAVNPEDRAAYSNFIQYVSQA LNKKHIKTMVSVPAKSADDKNDDWSWPYDYAKIGKYADFVQVMTYDEHGIWGEPGSVA STNWIKSSLQFSVKKIKANKVIMGIPAYGYDWDVKDGSTSTIREWNELKSLIKKQKAK PAFNKKSGSMTFSYVDKKKHKHVVWYENEKTVQTKSHLAKQYKIAGVSVYALGNESES FWKAIRKGTK*" /label="yvbX CDS" gene complement(3115978..3117012) /gene="yvbX" /locus_tag="BSU_34020" /old_locus_tag="BSU34020" /label="yvbX gene" promotor_-10 complement(3117034..3117052) /Source="Nicolas_upshift_promotors" /id="U2685" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2815 /SigmaFactorBS="catatgccgggctttttgcttgaaaaaaCTTCAACTtccaat tttttgGCCGATGAGAAGAGTATGActtgatacaggaggaaatgcgatgaaaaaatgg c" /listShort="yvbX, S1305, NA, yvbW" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3117040) /Source="Nicolas_upshifts" /id="U2685" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2815 /SigmaFactorBS="catatgccgggctttttgcttgaaaaaaCTTCAACTtccaat tttttgGCCGATGAGAAGAGTATGActtgatacaggaggaaatgcgatgaaaaaatgg c" /listShort="yvbX, S1305, NA, yvbW" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3117065..3117072) /Source="Nicolas_upshift_promotors" /id="U2685" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2815 /SigmaFactorBS="catatgccgggctttttgcttgaaaaaaCTTCAACTtccaat tttttgGCCGATGAGAAGAGTATGActtgatacaggaggaaatgcgatgaaaaaatgg c" /listShort="yvbX, S1305, NA, yvbW" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3117120..3117842) /gene="lutC" /locus_tag="BSU_34030" /old_locus_tag="BSU34030" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:22427629, 24196425, 24274019" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22427629, 24196425, 24274019; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="component of an iron-sulfur oxidase for L-lactate utilization" /protein_id="NP_391283.1" /db_xref="EnsemblGenomes-Gn:BSU34030" /db_xref="EnsemblGenomes-Tr:CAB15408" /db_xref="InterPro:IPR003741" /db_xref="InterPro:IPR022823" /db_xref="SubtiList:BG14091" /db_xref="UniProtKB/Swiss-Prot:O32259" /translation="MTKGTIQNQESFLNRIASSLGRERRTGGVAVPEWAHQPQYKTLE GYSADDLVTVLKNHCVKIHTELIETDSTGLYDALREQVSRFSGGPVIIPKDPRFEEYG LKSLLTKDWPSEGTPVWEWDADKGEENIKKAEQANVGITFSEITLAESGTVVLFSSKD IGRSVSLLPTTYIAIVPKSSIVPRMTQASDIIRQNIANGVTVPSCINYITGPSNSADI EMDLVVGVHGPVKAAYILVSDR*" /label="lutC CDS" gene complement(3117120..3117842) /gene="lutC" /locus_tag="BSU_34030" /old_locus_tag="BSU34030" /label="lutC gene" downshifts complement(3117136) /Source="Nicolas_upshifts" /id="D1771" /incds=0 /nref=194 /ntot=266 /MaxReadThrough="4.5919" /MaxDrop="7.41457" /score="25.5917046" /energy="-15.7" /TU="U2689" /idTUdmin="U2689" /TUdmin="-1423" /isTUend="FALSE" /label="downshifts" CDS complement(3117842..3119281) /gene="lutB" /locus_tag="BSU_34040" /old_locus_tag="BSU34040" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16513748, 19201793, 19508281, 22427629, 24196425, 24274019, 28032445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16513748, 19201793, 19508281, 22427629, 24196425, 24274019, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="component of an iron-sulfur oxidase linked to L-lactate utilization" /protein_id="NP_391284.1" /db_xref="EnsemblGenomes-Gn:BSU34040" /db_xref="EnsemblGenomes-Tr:CAB15409" /db_xref="GOA:O07021" /db_xref="InterPro:IPR003741" /db_xref="InterPro:IPR004452" /db_xref="InterPro:IPR009051" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR017900" /db_xref="InterPro:IPR022825" /db_xref="InterPro:IPR024569" /db_xref="SubtiList:BG12448" /db_xref="UniProtKB/Swiss-Prot:O07021" /translation="MAMKIGTDAFKERVSQGIDNEFMRGAVSGAQERLRTRRLEAAEE LGNWEEWRSLSEEIRQHVLENLDFYLGQLAENVAKRGGHVYFAKTAEEASSYIRDVIQ KKNGKKIVKSKSMVTEEINLNEVLEKEGCEVVETDLGEYILQIDDHDPPSHIVAPALH KNKEQIRDVFKERLDYQHTEKPEELVMHARAILRKKFLEADIGITGCNFAIADTGSVS LVTNEGNGRLVSTLPKTQITVMGMERIVPSFSEFEVLVSMLTRSAVGQRLTSYITALT GPKLEGEVDGPEEFHLVIVDNGRSNILGTEFQSVLQCIRCAACINVCPVYRHVGGHSY GSIYSGPIGAVLSPLLGGYDDYKELPYASSLCAACSEACPVKIPLHELLLKHRQNIVE KEGRAPISEKLAMKAFGLGASSLSLYKMGSKWAPAAMTPFTEDEKISKGPGPLKNWTQ IRDFPAPHKSRFRDWFADRETSERTKEEQ*" /label="lutB CDS" gene complement(3117842..3119281) /gene="lutB" /locus_tag="BSU_34040" /old_locus_tag="BSU34040" /label="lutB gene" promotor_-35 3118829..3118832 /Source="Nicolas_upshift_promotors" /id="U2686" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.967032967032967" /psig="0.001998001998002" /xcortree=71 /SigmaFactorBS="gctctttatttttatgaagagcgggcgctacgatatgtgaCG GCggatcgtgatcatcaatCTGCAaaatatactcgccgagatcggtttctacgacttc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3118849 /Source="Nicolas_upshifts" /id="U2686" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.967032967032967" /psig="0.001998001998002" /xcortree=71 /SigmaFactorBS="gctctttatttttatgaagagcgggcgctacgatatgtgaCG GCggatcgtgatcatcaatCTGCAaaatatactcgccgagatcggtttctacgacttc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3118850..3118854 /Source="Nicolas_upshift_promotors" /id="U2686" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.967032967032967" /psig="0.001998001998002" /xcortree=71 /SigmaFactorBS="gctctttatttttatgaagagcgggcgctacgatatgtgaCG GCggatcgtgatcatcaatCTGCAaaatatactcgccgagatcggtttctacgacttc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 3119003 /Source="Nicolas_upshifts" /id="D1772" /incds=1 /nref=1 /ntot=175 /MaxReadThrough="1.77859" /MaxDrop="3.31917" /score="-7.50175872" /energy="-11.7" /TU="NA" /idTUdmin="U2686" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts 3119157 /Source="Nicolas_upshifts" /id="U2687" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.932067932067932" /psig="0.000999000999001" /xcortree=69 /SigmaFactorBS="acatgctgcctgatttcctctgataatgagcgccactcctcc cagtttcccagttcttctgCTgcctctaggcgccgcgtccgcagacgctcctgtgcac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 3119158..3119159 /Source="Nicolas_upshift_promotors" /id="U2687" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.932067932067932" /psig="0.000999000999001" /xcortree=69 /SigmaFactorBS="acatgctgcctgatttcctctgataatgagcgccactcctcc cagtttcccagttcttctgCTgcctctaggcgccgcgtccgcagacgctcctgtgcac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(3119308..3120024) /gene="lutA" /locus_tag="BSU_34050" /old_locus_tag="BSU34050" /EC_number="1.8.98.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16513748, 19201793, 19508281, 22427629, 24196425, 24274019, 28032445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16513748, 19201793, 19508281, 22427629, 24196425, 24274019, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="iron-sulfur oxidase subunit used in L-lactate utilization" /protein_id="NP_391285.1" /db_xref="EnsemblGenomes-Gn:BSU34050" /db_xref="EnsemblGenomes-Tr:CAB15410" /db_xref="GOA:O07020" /db_xref="InterPro:IPR004017" /db_xref="InterPro:IPR022822" /db_xref="SubtiList:BG12447" /db_xref="UniProtKB/Swiss-Prot:O07020" /translation="MKVSLFVTCLVDMFQTNVGKATVELLERLGCEVDFPEGQICCGQ PAYNSGYVHDAKKAMKRMIETFQDSEYVVSPSGSCTTMFREYPHLFQDDPKWADKAKK LADKTYELTDFIVNVLGVEDVGATLHTKATLHTSCHMTRLLGVRKEPMKLLSHVKGLQ FTELPGKHNCCGFGGTFSVKMAQISEQMVDEKVECVEETGAEVLIGADCGCLMNIGGR LGRKDKNVKVMHIAEVLNSR*" /label="lutA CDS" gene complement(3119308..3120024) /gene="lutA" /locus_tag="BSU_34050" /old_locus_tag="BSU34050" /label="lutA gene" promotor_-35 3119928..3119935 /Source="Nicolas_upshift_promotors" /id="U2688" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.982017982017982" /psig=0 /xcortree=72 /SigmaFactorBS="ccggctgtccgcagcaaatctgcccttctggaaaatcaaCCT CGCACccaagccgctccaGCAgctcaaccgttgcttttccgacatttgtttgaaacat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3119949..3119951 /Source="Nicolas_upshift_promotors" /id="U2688" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.982017982017982" /psig=0 /xcortree=72 /SigmaFactorBS="ccggctgtccgcagcaaatctgcccttctggaaaatcaaCCT CGCACccaagccgctccaGCAgctcaaccgttgcttttccgacatttgtttgaaacat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3119949 /Source="Nicolas_upshifts" /id="U2688" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.982017982017982" /psig=0 /xcortree=72 /SigmaFactorBS="ccggctgtccgcagcaaatctgcccttctggaaaatcaaCCT CGCACccaagccgctccaGCAgctcaaccgttgcttttccgacatttgtttgaaacat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 3120022 /Source="Nicolas_upshifts" /id="D1773" /incds=0 /nref=15 /ntot=169 /MaxReadThrough="1.96527" /MaxDrop="4.662" /score="-7.50175872" /energy="-11.7" /TU="NA" /idTUdmin="U2688" /TUdmin="-15" /isTUend="TRUE" /label="downshifts" S_feature complement(3120025..3120091) /Source="Nicolas_S_feature" /locus_tag="new_3495702_3495768_c" /HighExp="C90, M40t90, T3.0H, T4.0H, HiOs, T1.0H, T3.30H, T2.30H, Lbstat, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="SigA" /TUlongPSig=1 /label="S1306" promotor_-10 complement(3120088..3120107) /Source="Nicolas_upshift_promotors" /id="U2689" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.754245754245754" /psig="0.994005994005994" /xcortree=3211 /SigmaFactorBS="aaatgaaaatatccctagaaaaCTCTTTCCttccattgtcag aaTAGTGTACGATATTCATATAgttattttaactcaggtcatcagatgacctgatcat a" /listShort="S1306, yvfV, yvfW, yvbY, yvbX, S1305, NA" /listLong="yvbW" /label="promotor_-10" upshifts complement(3120091) /Source="Nicolas_upshifts" /id="U2689" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.754245754245754" /psig="0.994005994005994" /xcortree=3211 /SigmaFactorBS="aaatgaaaatatccctagaaaaCTCTTTCCttccattgtcag aaTAGTGTACGATATTCATATAgttattttaactcaggtcatcagatgacctgatcat a" /listShort="S1306, yvfV, yvfW, yvbY, yvbX, S1305, NA" /listLong="yvbW" /label="upshifts" promotor_-35 complement(3120122..3120129) /Source="Nicolas_upshift_promotors" /id="U2689" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.754245754245754" /psig="0.994005994005994" /xcortree=3211 /SigmaFactorBS="aaatgaaaatatccctagaaaaCTCTTTCCttccattgtcag aaTAGTGTACGATATTCATATAgttattttaactcaggtcatcagatgacctgatcat a" /listShort="S1306, yvfV, yvfW, yvbY, yvbX, S1305, NA" /listLong="yvbW" /label="promotor_-35" CDS complement(3120199..3120801) /gene="yvfU" /locus_tag="BSU_34060" /old_locus_tag="BSU34060" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 18925929, 23504016" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 18925929, 23504016; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YvfT]" /protein_id="NP_391286.1" /db_xref="EnsemblGenomes-Gn:BSU34060" /db_xref="EnsemblGenomes-Tr:CAB15411" /db_xref="GOA:O07019" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12446" /db_xref="UniProtKB/Swiss-Prot:O07019" /translation="MIRLFIAEDQRMLLGALGSLLDLEEDMTVIGQALNGEEALHAIL KLEPDVCIMDIEMPVRSGLNVAEELMKKGCVSKVIILTTFARPGYFERAVKAGAHGYL LKDGEIDDLADAIRKCVKGKRVFSPELTFNMMRDENPLTVREQEILRLAALGKTTKDI TLELYLSQGTVRNYISEIIQKLNAKNRTEAASIAEEKGWI*" /label="yvfU CDS" gene complement(3120199..3120801) /gene="yvfU" /locus_tag="BSU_34060" /old_locus_tag="BSU34060" /label="yvfU gene" CDS complement(3120818..3121933) /gene="yvfT" /locus_tag="BSU_34070" /old_locus_tag="BSU34070" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 18925929, 23504016" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 18925929, 23504016; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YvfU]" /protein_id="NP_391287.2" /db_xref="EnsemblGenomes-Gn:BSU34070" /db_xref="EnsemblGenomes-Tr:CAB15412" /db_xref="GOA:Q795K2" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12445" /db_xref="UniProtKB/Swiss-Prot:Q795K2" /translation="MKKAISIFPKEFGFFPYIFLVYTIMPFLSLLKESGVKQGIGYGM LLLFVAAYRQLFCSVGKASFTYWLIVQMAVILMYSVFYNITYIYLGFFPANFVGYYKE KTNFNRAFCALIFILLFPCLYQFIANSVSLRELFSVLPFLVIMLISPFGIRSMFRRIE LEAKLAQANEQIKELSKREERVRIARDLHDTLGHTLSLLTLKSQLIQRLAASDPERTK LEAKEMETSSRSALKQVRELVSDMRTVTITEELVNIQHILRAGNITFQYEGADDFSVI SPVTQNIISMCMREAVTNIIKHSKATHCAITISQFADKMRIVIRDDGKGAPKEKMFGN GLWGMEERLMLIEGGLTVSDHNGTVVALTIPLIKKAE*" /label="yvfT CDS" gene complement(3120818..3121933) /gene="yvfT" /locus_tag="BSU_34070" /old_locus_tag="BSU34070" /label="yvfT gene" CDS complement(3121937..3122674) /gene="yvfS" /locus_tag="BSU_34080" /old_locus_tag="BSU34080" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11717295, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (permease)" /protein_id="NP_391288.1" /db_xref="EnsemblGenomes-Gn:BSU34080" /db_xref="EnsemblGenomes-Tr:CAB15413" /db_xref="GOA:O07017" /db_xref="InterPro:IPR000412" /db_xref="SubtiList:BG12444" /db_xref="UniProtKB/Swiss-Prot:O07017" /translation="MNVLQKQSIAEMKRVLRNKYFVLWSLIMPIAFYYFFTNVVNTNV PDQRAWEAHYLMSMTVFSVMGSSIMTLGIRMVQERSQGWAAFIRLTPLPDHIYLSAQM IGQSVIHVLSITVIFLFGAIINDIALSPFEWMMSGLWILFGALPFLALGTLIGLMRKV ETAAGISNVLYMLLALGGGMWMPFEVMPDMMQSIGQWLPSYHFGSGAWELVRGGSPTW KNILILIAYMMLFMLLSKYIRRKQEAV*" /label="yvfS CDS" gene complement(3121937..3122674) /gene="yvfS" /locus_tag="BSU_34080" /old_locus_tag="BSU34080" /label="yvfS gene" promotor_-10 complement(3121963..3121982) /Source="Nicolas_upshift_promotors" /id="U2690" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.978021978021978" /psig=1 /xcortree=3117 /SigmaFactorBS="gtgggagtccgacttggaaaaatattctgatattaaTCGCTT ATatgatgctcttCATGCTACTATCTAAATATAtaagaagaaaacaagaagcggtgta a" /listShort="yvfT, yvfU" /listLong="S1306, yvfV, yvfW, yvbY, yvbX, S1305, NA" /label="promotor_-10" upshifts complement(3121977) /Source="Nicolas_upshifts" /id="U2690" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.978021978021978" /psig=1 /xcortree=3117 /SigmaFactorBS="gtgggagtccgacttggaaaaatattctgatattaaTCGCTT ATatgatgctcttCATGCTACTATCTAAATATAtaagaagaaaacaagaagcggtgta a" /listShort="yvfT, yvfU" /listLong="S1306, yvfV, yvfW, yvbY, yvbX, S1305, NA" /label="upshifts" promotor_-35 complement(3121994..3122001) /Source="Nicolas_upshift_promotors" /id="U2690" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.978021978021978" /psig=1 /xcortree=3117 /SigmaFactorBS="gtgggagtccgacttggaaaaatattctgatattaaTCGCTT ATatgatgctcttCATGCTACTATCTAAATATAtaagaagaaaacaagaagcggtgta a" /listShort="yvfT, yvfU" /listLong="S1306, yvfV, yvfW, yvbY, yvbX, S1305, NA" /label="promotor_-35" CDS complement(3122675..3123580) /gene="yvfR" /locus_tag="BSU_34090" /old_locus_tag="BSU34090" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11717295; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC efflux transporter (ATP-binding protein)" /protein_id="NP_391289.1" /db_xref="EnsemblGenomes-Gn:BSU34090" /db_xref="EnsemblGenomes-Tr:CAB15414" /db_xref="GOA:O07016" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12443" /db_xref="UniProtKB/Swiss-Prot:O07016" /translation="MMKEAVTVSNVTKHFQRKTAVNNISFSIEKGEIAAILGPNGAGK TTVVSMILGLLKPSEGEIKLFNRVPDDQQVREKIGVMLQEVSVMPGLKVDEILELFRS YYPNPLSMKELVSLTALTKEDLKTRAEKLSGGQKRRLSFALALAGNPELLILDEPTVG MDTSSRHRFWQTIHGLSDQGKTIIFSTHYLQEADDAAQRILFFTEGQLVADGSPMQIR SRIQKQSVSFTLHSSESLERLSCHPEVERVIHEHERTIIQTSNTDKVLALIFQENIHA RDIRIEQATLDEAFRQLADGNREAM*" /label="yvfR CDS" gene complement(3122675..3123580) /gene="yvfR" /locus_tag="BSU_34090" /old_locus_tag="BSU34090" /label="yvfR gene" promotor_-10 complement(3123600..3123618) /Source="Nicolas_upshift_promotors" /id="U2691" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.395604395604396" /psig="0.892107892107892" /xcortree=312 /SigmaFactorBS="gacatttgtcactccatcatcatgacaccccataCTAAcatc gtcttctccgtCATTTTACAATCAATGTAAacgatcaggaggtgctcatgtgatgaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3123611) /Source="Nicolas_upshifts" /id="U2691" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.395604395604396" /psig="0.892107892107892" /xcortree=312 /SigmaFactorBS="gacatttgtcactccatcatcatgacaccccataCTAAcatc gtcttctccgtCATTTTACAATCAATGTAAacgatcaggaggtgctcatgtgatgaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3123634..3123637) /Source="Nicolas_upshift_promotors" /id="U2691" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.395604395604396" /psig="0.892107892107892" /xcortree=312 /SigmaFactorBS="gacatttgtcactccatcatcatgacaccccataCTAAcatc gtcttctccgtCATTTTACAATCAATGTAAacgatcaggaggtgctcatgtgatgaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3123789..3123796 /Source="Nicolas_upshift_promotors" /id="U2692" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2247 /SigmaFactorBS="ttcttttaaactgctgtgacattcatagaaagataCACTCTT CaaaccatccgAGTGTTATGATAGAAATATTgaactttatattactttccggctgaaa g" /listShort="rsbQ, rsbP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3123807..3123826 /Source="Nicolas_upshift_promotors" /id="U2692" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2247 /SigmaFactorBS="ttcttttaaactgctgtgacattcatagaaagataCACTCTT CaaaccatccgAGTGTTATGATAGAAATATTgaactttatattactttccggctgaaa g" /listShort="rsbQ, rsbP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3123814 /Source="Nicolas_upshifts" /id="U2692" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2247 /SigmaFactorBS="ttcttttaaactgctgtgacattcatagaaagataCACTCTT CaaaccatccgAGTGTTATGATAGAAATATTgaactttatattactttccggctgaaa g" /listShort="rsbQ, rsbP" /GFF_Attribute="listLong" /label="upshifts" CDS 3123864..3124673 /gene="rsbQ" /locus_tag="BSU_34100" /old_locus_tag="BSU34100" /function="16.3: Control" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11591687, 12620626, 15632289, 21980452" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11591687, 12620626, 15632289, 21980452; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of RsbP phosphatase" /protein_id="NP_391290.1" /db_xref="EnsemblGenomes-Gn:BSU34100" /db_xref="EnsemblGenomes-Tr:CAB15415" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="InterPro:IPR031143" /db_xref="PDB:1WOM" /db_xref="PDB:1WPR" /db_xref="SubtiList:BG12442" /db_xref="UniProtKB/Swiss-Prot:O07015" /translation="MNEAILSRNHVKVKGSGKASIMFAPGFGCDQSVWNAVAPAFEED HRVILFDYVGSGHSDLRAYDLNRYQTLDGYAQDVLDVCEALDLKETVFVGHSVGALIG MLASIRRPELFSHLVMVGPSPCYLNDPPEYYGGFEEEQLLGLLEMMEKNYIGWATVFA ATVLNQPDRPEIKEELESRFCSTDPVIARQFAKAAFFSDHREDLSKVTVPSLILQCAD DIIAPATVGKYMHQHLPYSSLKQMEARGHCPHMSHPDETIQLIGDYLKAHV*" /label="rsbQ CDS" gene 3123864..3124673 /gene="rsbQ" /locus_tag="BSU_34100" /old_locus_tag="BSU34100" /label="rsbQ gene" CDS 3124709..3125920 /gene="rsbP" /locus_tag="BSU_34110" /old_locus_tag="BSU34110" /EC_number="3.1.3.3" /function="16.8: Protect" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10632888, 11591687, 15342585, 15632289, 16267279, 19948797, 21980452, 23524614" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10632888, 11591687, 15342585, 15632289, 16267279, 19948797, 21980452, 23524614; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoserine protein-phosphatase" /protein_id="NP_391291.1" /db_xref="EnsemblGenomes-Gn:BSU34110" /db_xref="EnsemblGenomes-Tr:CAB15416" /db_xref="GOA:O07014" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR001932" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036457" /db_xref="SubtiList:BG12441" /db_xref="UniProtKB/Swiss-Prot:O07014" /translation="MDKQLNDAPCGFLALSEEGSIIAANRTLIKILDYEPEQVIGQHM NMMLTIPAQLFCQLYFFPLLKLEHHIEEIYISLKARDGEEIPVLINAIARHDSGASVF DCVLIPMRKRNEYENELLIARNEAQEALLAKQKANAELEIALETLKAKQEELLEINKQ NQQFKLNTKRELELARKIQKNSLTEPIVNDQVQIDSYYNASSELSGDLYGYYQIDEHR YGIIILDVMGHGISSALITMSLHPLFQRQITQGLSPVKVMKELDRHLHSLFQNDEEAR HYCTAIYLEIDIARQRIDYVNAGHPPALWQDDSGTQHLLHATSPPIGMFEDLEFQSSS LSYTEDGRLLLYTDGVMDPTASCYLFDLLKDHPDSPIADLKEKILTSLQHQKEAHHKS DDECFILVDVK*" /label="rsbP CDS" gene 3124709..3125920 /gene="rsbP" /locus_tag="BSU_34110" /old_locus_tag="BSU34110" /label="rsbP gene" downshifts 3125907 /Source="Nicolas_upshifts" /id="D1774" /incds=0 /nref=181 /ntot=246 /MaxReadThrough="0.90827" /MaxDrop="5.41923" /score="26.3528321" /energy="-17.8" /TU="NA" /idTUdmin="U2692" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(3125974..3127263) /gene="ganB" /locus_tag="BSU_34120" /old_locus_tag="BSU34120" /EC_number="3.2.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11682178, 17056685, 27501980" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11682178, 17056685, 27501980; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endo-beta-1,4-galactanase" /protein_id="NP_391292.2" /db_xref="EnsemblGenomes-Gn:BSU34120" /db_xref="EnsemblGenomes-Tr:CAB15417" /db_xref="GOA:O07013" /db_xref="InterPro:IPR011683" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG12440" /db_xref="UniProtKB/Swiss-Prot:O07013" /translation="MKSKVKMFFAAAIVWSACSSTGYAAAIEKEKHVSELRAEDLFVK KVEGMNKDFIKGADVSSVIALENSGVTFYNTNGKRQDIFTTLKQAGVNYVRVRIWNHP YDSNGNGYGGGNNDVQKAIEIGKRATANGMKVLADFHYSDFWADPAKQKVPKAWANLS FEAKKAKLYEYTKQSLQKMIKEGVDIGMVQVGNETTGGFAGETDWTKMCQLFNEGSRA VRETNSNILVALHFTNPETAGRYSFIAETLSKNKVDYDVFASSYYPFWHGTLQNLTSV LKAVANTYGKKVMVAETSYTYTAEDGDGHGNTAPKSGQTLPYPISVQGQATAVRDVME AVANTGKAGLGVFYWEPAWIPVGPKTQIEKNKVLWETYGSGWASSYAAEYDPEDAGKW YGGSAVDNQALFDFNGHPLPSLQVFQYAESGHIPKKR*" /label="ganB CDS" gene complement(3125974..3127263) /gene="ganB" /locus_tag="BSU_34120" /old_locus_tag="BSU34120" /label="ganB gene" CDS complement(3127343..3129406) /gene="ganA" /locus_tag="BSU_34130" /old_locus_tag="BSU34130" /EC_number="3.2.1.23" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2104611, 9287030, 17056685, 27501980" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2104611, 9287030, 17056685, 27501980; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="short chain beta-1,4-galacto-oligosaccharides beta-galactosidase (beta-galacto-pyranoside hydrolase)" /protein_id="NP_391293.1" /db_xref="EnsemblGenomes-Gn:BSU34130" /db_xref="EnsemblGenomes-Tr:CAB15418" /db_xref="GOA:O07012" /db_xref="InterPro:IPR003476" /db_xref="InterPro:IPR013529" /db_xref="InterPro:IPR013738" /db_xref="InterPro:IPR013739" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG12439" /db_xref="UniProtKB/Swiss-Prot:O07012" /translation="MMSKLEKTHVTKAKFMLHGGDYNPDQWLDRPDILADDIKLMKLS HTNTFSVGIFAWSALEPEEGVYQFEWLDDIFERIHSIGGRVILATPSGARPAWLSQTY PEVLRVNASRVKQLHGGRHNHCLTSKVYREKTRHINRLLAERYGHHPALLMWHISNEY GGDCHCDLCQHAFREWLKSKYDNSLKTLNHAWWTPFWSHTFNDWSQIESPSPIGENGL HGLNLDWRRFVTDQTISFYENEIIPLKELTPDIPITTNFMADTPDLIPYQGLDYSKFA KHVDAISWDAYPVWHNDWESTADLAMKVGFINDLYRSLKQQPFLLMECTPSAVNWHNV NKAKRPGMNLLSSMQMIAHGSDSVLYFQYRKSRGSSEKLHGAVVDHDNSPKNRVFQEV AKVGETLERLSEVVGTKRPAQTAILYDWENHWALEDAQGFAKATKRYPQTLQQHYRTF WEHDIPVDVITKEQDFSPYKLLIVPMLYLISEDTVSRLKAFTADGGTLVMTYISGVVN EHDLTYTGGWHPDLQAIFGVEPLETDTLYPKDRNAVSYRSQIYEMKDYATVIDVKTAS VEAVYQEDFYARTPAVTSHEYQQGKAYFIGARLEDQFQRDFYEGLITDLSLSPVFPVR HGKGVSVQARQDQDNDYIFVMNFTEEKQLVTFDQSVKDIMTGDILSGDLTMEKYEVRI VVNTH*" /label="ganA CDS" gene complement(3127343..3129406) /gene="ganA" /locus_tag="BSU_34130" /old_locus_tag="BSU34130" /label="ganA gene" CDS complement(3129425..3130276) /gene="ganQ" /locus_tag="BSU_34140" /old_locus_tag="BSU34140" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 17056685, 27501980" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 17056685, 27501980; Product type t: transporter" /codon_start=1 /transl_table=11 /product="galacto-oligosaccharides (galactan) oligomer permease" /protein_id="NP_391294.1" /db_xref="EnsemblGenomes-Gn:BSU34140" /db_xref="EnsemblGenomes-Tr:CAB15419" /db_xref="GOA:O07011" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12438" /db_xref="UniProtKB/Swiss-Prot:O07011" /translation="MLADMKVRRYIRLLFSYLLLAFMAVIIVYPLLWTAGASFNPGNS LISTSIIPKHPTFDHYKELFAGKESLQYVQWYVNSMKISLFTMAGSLLCVTFTAYAFS RFRFKGRKYALTLFLLLQMIPQFSALIALFVLAQILGMINSHWLLILLYIGGLIPMNT YLMKGYMDSIPMDLDESAKIDGASSTRIFFQIILPLSKPMAAVVAMNGFTGPLGDFVL SSTILRTPESYTLPVGLFNLVNDVMGASYTTFAAGALLISIPVAVIFIMLQKNFVSGL TAGGTKG*" /label="ganQ CDS" gene complement(3129425..3130276) /gene="ganQ" /locus_tag="BSU_34140" /old_locus_tag="BSU34140" /label="ganQ gene" CDS complement(3130280..3131536) /gene="ganP" /locus_tag="BSU_34150" /old_locus_tag="BSU34150" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11160890, 15849754, 16850406, 17056685, 27501980" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11160890, 15849754, 16850406, 17056685, 27501980; Product type t : transporter" /codon_start=1 /transl_table=11 /product="galacto-oligosaccharides (galactan) oligomer permease" /protein_id="NP_391295.1" /db_xref="EnsemblGenomes-Gn:BSU34150" /db_xref="EnsemblGenomes-Tr:CAB15420" /db_xref="GOA:O32261" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035277" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12437" /db_xref="UniProtKB/Swiss-Prot:O32261" /translation="MQHRQVALLLSIIPGLGQFYNKQWIKGIVFLFLGASFFAVFGDL LNMGFWGIFTLGTEVPRDNSVFLLAEGIIAVIVTCFGLAVYYVNLRDAFQSGKQRDEN KPLSSLKEQYQHIISEGYPYVVSGPSLFILIFAVIFPILFSFALAFTNYDLYHSPPAK LIDWVGFQTFANIFTVDIWRSTFFDVLAWTVVWTLAASTLQVTLGIFLAIIVNQKDLR FKRFFRTILILPWAVPGFVTILIFAGLFNDSFGAMNHDILAFFGIDPLPWMTDANWSR LALILMQGWLGFPYIFLVSTGVLQSIPDDLYEAATIDGASVFSKLRYITLPMVFIAMA PIIITQFTFNFNNFNIIYLFNGGGPAVTGSTAGGTDILVSWIYKLTMQSSQYSLAAAL TILLSVFVISIALWQFRQTKSFKEEA*" /label="ganP CDS" gene complement(3130280..3131536) /gene="ganP" /locus_tag="BSU_34150" /old_locus_tag="BSU34150" /label="ganP gene" CDS complement(3131576..3132841) /gene="ganS" /locus_tag="BSU_34160" /old_locus_tag="BSU34160" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11682178, 27501980" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11682178, 27501980; Product type t: transporter" /codon_start=1 /transl_table=11 /product="polygalactose / cyclodextrin-binding lipoprotein" /protein_id="NP_391296.1" /db_xref="EnsemblGenomes-Gn:BSU34160" /db_xref="EnsemblGenomes-Tr:CAB15421" /db_xref="GOA:O07009" /db_xref="InterPro:IPR006060" /db_xref="SubtiList:BG12436" /db_xref="UniProtKB/Swiss-Prot:O07009" /translation="MKMAKKCSVFMLCAAVSLSLAACGPKESSSAKSSSKGSELVVWE DKEKSNGIKDAVAAFEKEHDVKVKVVEKPYAKQIEDLRMDGPAGTGPDVLTMPGDQIG TAVTEGLLKELHVKKDVQSLYTDASIQSQMVDQKLYGLPKAVETTVLFYNKDLITEKE LPKTLEEWYDYSKKTADGSKFGFLALFDQIYYAESVMSGYGGYIFGKAKDGSYNPSDI GINNEGAVKGAALIQKFYKDGLFPAGIIGEQGINVLESLFTEGKAAAIISGPWNVEAF SNAGINYGITKLPKLENGKNMSSFIGVKSYNVSAFSKNEELAQELAVFLANEKNSKTR YEETKEVPAVKSLANDPAIMKSEAARAVTEQSRFSEPTPNIPEMNEIWTPADSALQTV ATGKADPKQALDQAAETAKGQIKAKHSGK*" /label="ganS CDS" gene complement(3131576..3132841) /gene="ganS" /locus_tag="BSU_34160" /old_locus_tag="BSU34160" /label="ganS gene" promotor_-10 complement(3132873..3132892) /Source="Nicolas_upshift_promotors" /id="U2693" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.968031968031968" /psig=1 /xcortree=325 /SigmaFactorBS="tttatttaggtaaaaaaatttactctatgaagtaaatagttT GTTTACAcattttctcaggcaTGCTATATTATCTTTAAAGCgctttcattcctaccga a" /listShort="cycB, ganP, ganQ, ganA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3132895) /Source="Nicolas_upshifts" /id="U2693" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.968031968031968" /psig=1 /xcortree=325 /SigmaFactorBS="tttatttaggtaaaaaaatttactctatgaagtaaatagttT GTTTACAcattttctcaggcaTGCTATATTATCTTTAAAGCgctttcattcctaccga a" /listShort="cycB, ganP, ganQ, ganA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3132907..3132914) /Source="Nicolas_upshift_promotors" /id="U2693" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.968031968031968" /psig=1 /xcortree=325 /SigmaFactorBS="tttatttaggtaaaaaaatttactctatgaagtaaatagttT GTTTACAcattttctcaggcaTGCTATATTATCTTTAAAGCgctttcattcctaccga a" /listShort="cycB, ganP, ganQ, ganA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3132982..3133974) /gene="ganR" /locus_tag="BSU_34170" /old_locus_tag="BSU34170" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:2104611, 9287030, 10486575, 17056685, 27501980, 28617843" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2104611, 9287030, 10486575, 17056685, 27501980, 28617843; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of the galactan degradation operon (GanR / beta-1,4-galactobiose)" /protein_id="NP_391297.1" /db_xref="EnsemblGenomes-Gn:BSU34170" /db_xref="EnsemblGenomes-Tr:CAB15422" /db_xref="GOA:O07008" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG12435" /db_xref="UniProtKB/Swiss-Prot:O07008" /translation="MATIKDIAQEAGFSISTVSRVLNNDESLSVPDETREKIYEAAEK LNYRKKTVRPLVKHIAFLYWLTDKEELEDVYFKTMRLEVEKLAKAFNVDMTTYKIADG IESIPEHTEGFIAVGTFSDEELAFLRNLTENGVFIDSTPDPDHFDSVRPDLAQMTRKT VNILTEKGHKSIGFIGGTYKNPNTNQDEMDIREQTFRSYMREKAMLDERYIFCHRGFS VENGYRLMSAAIDTLGDQLPTAFMIAADPIAVGCLQALNEKGIAIPNRVSIVSINNIS FAKYVSPPLTTFHIDIHELCKNAVQLLLEQVQDKRRTVKTLYVGAELIVRKSMN*" /label="ganR CDS" gene complement(3132982..3133974) /gene="ganR" /locus_tag="BSU_34170" /old_locus_tag="BSU34170" /label="ganR gene" downshifts complement(3133016) /Source="Nicolas_upshifts" /id="D1775" /incds=0 /nref=2 /ntot=55 /MaxReadThrough="1.40325" /MaxDrop="2.80992" /score="14.7399792" /energy="-8.3" /TU="NA" /idTUdmin="U2694" /TUdmin=1111 /isTUend="FALSE" /label="downshifts" S_feature complement(3134104..3134153) /Source="Nicolas_S_feature" /locus_tag="new_3509781_3509830_c" /HighExp="Sw, BC, M0t90, M40t90, B60, Lbstat, Lbtran, S2, B36, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.29208099999999998" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1307" downshifts complement(3134127) /Source="Nicolas_upshifts" /id="D1776" /incds=0 /nref=88 /ntot=240 /MaxReadThrough="1.88481" /MaxDrop="5.0699" /score="7.28170345" /energy="-13.7" /TU="NA" /idTUdmin="U2694" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3134154..3134813) /gene="lutR" /locus_tag="BSU_34180" /old_locus_tag="BSU34180" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18604637, 24196425, 25031425" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18604637, 24196425, 25031425; Product type r: regulator" /codon_start=1 /transl_table=11 /product="L-lactate utilization global transcriptional regulator (GntR family)" /protein_id="NP_391298.2" /db_xref="EnsemblGenomes-Gn:BSU34180" /db_xref="EnsemblGenomes-Tr:CAB15423" /db_xref="GOA:O07007" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR008920" /db_xref="InterPro:IPR011711" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12434" /db_xref="UniProtKB/Swiss-Prot:O07007" /translation="MIKNGELKPGDKLDSVQALAESFQVSRSAVREALSALKAMGLVE MKQGEGTYLKEFELNQISQPLSAALLMKKEDVKQLLEVRKLLEIGVASLAAEKRTEAD LERIQDALKEMGSIEADGELGEKADFAFHLALADASQNELLKHLMNHVSSLLLETMRE TRKIWLFSKKTSVQRLYEEHERIYNAVAAGNGAQAEAAMLAHLTNVEDVLSGYFEENV Q*" /label="lutR CDS" gene complement(3134154..3134813) /gene="lutR" /locus_tag="BSU_34180" /old_locus_tag="BSU34180" /label="lutR gene" S_feature complement(3134814..3134919) /Source="Nicolas_S_feature" /locus_tag="new_3510491_3510596_c" /HighExp="M0t90, Lbstat, BC, M40t90, Lbtran, Sw, S2, B60, ferm, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.69672000000000001" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1308" promotor_-10 complement(3134911..3134930) /Source="Nicolas_upshift_promotors" /id="U2694" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.967032967032967" /psig="0.999000999001" /xcortree=1596 /SigmaFactorBS="agtacaagactttttgacaaaatagtcaaaatCTTTtggcgg cccacaaaACAGAGTATAATAGATCGTAaacagccagacctacaagttacggggtgaa t" /listShort="S1308, yvfI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3134920) /Source="Nicolas_upshifts" /id="U2694" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.967032967032967" /psig="0.999000999001" /xcortree=1596 /SigmaFactorBS="agtacaagactttttgacaaaatagtcaaaatCTTTtggcgg cccacaaaACAGAGTATAATAGATCGTAaacagccagacctacaagttacggggtgaa t" /listShort="S1308, yvfI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3134945..3134948) /Source="Nicolas_upshift_promotors" /id="U2694" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.967032967032967" /psig="0.999000999001" /xcortree=1596 /SigmaFactorBS="agtacaagactttttgacaaaatagtcaaaatCTTTtggcgg cccacaaaACAGAGTATAATAGATCGTAaacagccagacctacaagttacggggtgaa t" /listShort="S1308, yvfI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3134972..3134979 /Source="Nicolas_upshift_promotors" /id="U2695" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.516483516483517" /psig=1 /xcortree=494 /SigmaFactorBS="gtgggccgccaaaagattttgactattttgtcaaaaagTCTT GTACtttgatttttttcaAAATATAATGCTAGGTAACTggtcttattacccagtcatc a" /listShort="S1309, yvfH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3134994..3135013 /Source="Nicolas_upshift_promotors" /id="U2695" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.516483516483517" /psig=1 /xcortree=494 /SigmaFactorBS="gtgggccgccaaaagattttgactattttgtcaaaaagTCTT GTACtttgatttttttcaAAATATAATGCTAGGTAACTggtcttattacccagtcatc a" /listShort="S1309, yvfH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3134994 /Source="Nicolas_upshifts" /id="U2695" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.516483516483517" /psig=1 /xcortree=494 /SigmaFactorBS="gtgggccgccaaaagattttgactattttgtcaaaaagTCTT GTACtttgatttttttcaAAATATAATGCTAGGTAACTggtcttattacccagtcatc a" /listShort="S1309, yvfH" /GFF_Attribute="listLong" /label="upshifts" S_feature 3134997..3135102 /Source="Nicolas_S_feature" /locus_tag="new_3510674_3510779" /HighExp="T1.30H, S1, T1.0H, M40t90, T2.0H, M0t90, T3.0H, T2.30H, T0.30H, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1309" promotor_-10 complement(3135003..3135020) /Source="Nicolas_upshift_promotors" /id="U2696" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.543456543456543" /psig="0.330669330669331" /xcortree=381 /SigmaFactorBS="atgtaagcggtttctatagatgatatgatcatcTGATGACtg ggtaaTAAGACCAGTTACCTAGCattatattttgaaaaaaatcaaagtacaagacttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3135007) /Source="Nicolas_upshifts" /id="U2696" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.543456543456543" /psig="0.330669330669331" /xcortree=381 /SigmaFactorBS="atgtaagcggtttctatagatgatatgatcatcTGATGACtg ggtaaTAAGACCAGTTACCTAGCattatattttgaaaaaaatcaaagtacaagacttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3135028..3135034) /Source="Nicolas_upshift_promotors" /id="U2696" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.543456543456543" /psig="0.330669330669331" /xcortree=381 /SigmaFactorBS="atgtaagcggtttctatagatgatatgatcatcTGATGACtg ggtaaTAAGACCAGTTACCTAGCattatattttgaaaaaaatcaaagtacaagacttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3135103..3136794 /gene="lutP" /locus_tag="BSU_34190" /old_locus_tag="BSU34190" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 25031425; Product type t: transporter" /codon_start=1 /transl_table=11 /product="L-lactate permease" /protein_id="NP_391299.1" /db_xref="EnsemblGenomes-Gn:BSU34190" /db_xref="EnsemblGenomes-Tr:CAB15424" /db_xref="GOA:P71067" /db_xref="InterPro:IPR003804" /db_xref="SubtiList:BG11875" /db_xref="UniProtKB/Swiss-Prot:P71067" /translation="MQWTQAYTPIGGNLLLSALAALVPIIFFFWALAIKRMKGYTAGL ATLGIALIIAVLVYRMPAEKALMSATQGAVYGLLPIGWIIVTSVFLYKITVKTGQFDI IRSSVLSITDDRRLQALLIAFSFGAFLEGAAGFGAPVAISAALLVGLGFNPLYAAGIC LIANTAPVAFGAIGIPITAVEGPTGIPAMEISQMVGRQLPFLSVFIPLYLIIIMSGFR KALEIWPAILVSGVSFAVVQYLSSNFLGPELPDVLSALVSMAALAVFLKWWKPKTTFR FAGEQESAASIETARTNPAAPAYRGGQIFKAWSPFLLLTAMISVWGIPSVKSALTGHY EGSAVFLKWLNAVGEKLTFSPGVPFLNNQIVNADGTPIEAVYKLEVLGSAGTAILIAA VLSKFITAISWKDWGTVFKETVQELKLPILTIASVVGFAYVTNSSGMSTTLGMTLALT GSMFTFFSPVLGWLGVFITGSDTSANLLFGNLQKVTALSVGMDPVLSVAANSSGGVTG KMISPQSIAVACAAVGLAGKESDLFRFTIKHSLFLLLLVCIITFLQHHVFSWMIP*" /label="lutP CDS" gene 3135103..3136794 /gene="lutP" /locus_tag="BSU_34190" /old_locus_tag="BSU34190" /label="lutP gene" downshifts 3136779 /Source="Nicolas_upshifts" /id="D1777" /incds=0 /nref=153 /ntot=245 /MaxReadThrough="4.82757" /MaxDrop="5.44233" /score="20.8815301" /energy="-11.7" /TU="NA" /idTUdmin="U2695" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3136821..3138131) /gene="sigL" /locus_tag="BSU_34200" /old_locus_tag="BSU34200" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11274109, 12533460, 12634342, 16166551, 16585774" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11274109, 12533460, 12634342, 16166551, 16585774; Product type r: regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase sigma-54 factor (sigma-L)" /protein_id="NP_391300.1" /db_xref="EnsemblGenomes-Gn:BSU34200" /db_xref="EnsemblGenomes-Tr:CAB15425" /db_xref="GOA:P24219" /db_xref="InterPro:IPR000394" /db_xref="InterPro:IPR007046" /db_xref="InterPro:IPR007634" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10748" /db_xref="UniProtKB/Swiss-Prot:P24219" /translation="MDMKLQQVQVLKPQLTQELRQAITLLGYHSAELAEYIDELSLEN PLIERKETDTPPLSYHKTNKNRMNAQEAGLQLSNPQKTLQDALKQQSLDMNLTNTEKK IFNYLIHSLDSNGYLEEDIEEAARRLSVSAKEAEAVLAKLQSLEPAGIGARSLQECIL LQLQRLPNRNEQAEMLVSAHFDAFAQKKWKTLSVETGIPLHTIQDISDDIAALHPRPG LLFARPEQDVYIEPDIFITVKNGHIAAELNTRSFPEIDLHPQYRTLLSSGSCQDTVSY LSAKYQEWRWLSRALRQRKQTITRIINELITRQKDFFLKGRSAMKPLTLREVADCLSL HESTVSRAIKGKTIQTPYGLFEMKLFFSAKAEASGDGDASNYAVKTHLENLINQEDKT KPLSDQKLVDLLYEQHGIQISRRTVAKYRDQMNIPSSAARKRYK*" /label="sigL CDS" gene complement(3136821..3138131) /gene="sigL" /locus_tag="BSU_34200" /old_locus_tag="BSU34200" /label="sigL gene" S_feature 3136824..3137894 /Source="Nicolas_S_feature" /locus_tag="new_3512501_3513571" /HighExp="M9-stat, T1.30H, S1, Sw, T1.0H, T2.0H, T0.30H, G/S, T3.30H, T2.30H" /AntisenseName="sigL" /AntisenseCor="0.63927172079726402" /AntisenseRegPval="-31.6" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1310" downshifts complement(3136833) /Source="Nicolas_upshifts" /id="D1778" /incds=0 /nref=62 /ntot=219 /MaxReadThrough="2.33779" /MaxDrop="5.56948" /score="28.2409666" /energy="-11.7" /TU="NA" /idTUdmin="U2698" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature 3137951..3137970 /Source="Nicolas_upshift_promotors" /id="U2697" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.656343656343656" /psig=1 /xcortree=2629 /SigmaFactorBS="tttgcggattacttaattgaaggcccgcttcctgtgcattca tcctgtttttgtttgtttTATGGTAAGATAGTGGCGGTgtgtctgtttcctttcgttc a" /listShort="S1311, yvfG" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 3137951..3138209 /Source="Nicolas_S_feature" /locus_tag="new_3513628_3513886" /HighExp="LBGstat, LBGexp, G180, Paraq, H2O2, LBGtran, Oxctl, Lbexp, dia0, HPh" /AntisenseName="sigL" /AntisenseCor="-0.50245218771496702" /AntisenseRegPval="-17.899999999999999" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1311" upshifts 3137951 /Source="Nicolas_upshifts" /id="U2697" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.656343656343656" /psig=1 /xcortree=2629 /SigmaFactorBS="tttgcggattacttaattgaaggcccgcttcctgtgcattca tcctgtttttgtttgtttTATGGTAAGATAGTGGCGGTgtgtctgtttcctttcgttc a" /listShort="S1311, yvfG" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3138145..3138164) /Source="Nicolas_upshift_promotors" /id="U2698" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.94005994005994" /psig=1 /xcortree=424 /SigmaFactorBS="agttcagacatttctttggcagctcctttttcataaatGTAT acggtgtgatctcaATCATGTACAATGAAGAAAGgggagtgagcaagatggatatgaa a" /listShort="sigL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3138160) /Source="Nicolas_upshifts" /id="U2698" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.94005994005994" /psig=1 /xcortree=424 /SigmaFactorBS="agttcagacatttctttggcagctcctttttcataaatGTAT acggtgtgatctcaATCATGTACAATGAAGAAAGgggagtgagcaagatggatatgaa a" /listShort="sigL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3138179..3138182) /Source="Nicolas_upshift_promotors" /id="U2698" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.94005994005994" /psig=1 /xcortree=424 /SigmaFactorBS="agttcagacatttctttggcagctcctttttcataaatGTAT acggtgtgatctcaATCATGTACAATGAAGAAAGgggagtgagcaagatggatatgaa a" /listShort="sigL" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3138210..3138428 /gene="yvfG" /locus_tag="BSU_34210" /old_locus_tag="BSU34210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391301.1" /db_xref="EnsemblGenomes-Gn:BSU34210" /db_xref="EnsemblGenomes-Tr:CAB15426" /db_xref="InterPro:IPR018590" /db_xref="PDB:2GSV" /db_xref="PDB:2JS1" /db_xref="SubtiList:BG11876" /db_xref="UniProtKB/Swiss-Prot:P71066" /translation="MSELFSVPYFIENLKQHIEMNQSEDKIHAMNSYYRSVVSTLVQD QLTKNAVVLKRIQHLDEAYNKVKRGESK*" /label="yvfG CDS" gene 3138210..3138428 /gene="yvfG" /locus_tag="BSU_34210" /old_locus_tag="BSU34210" /label="yvfG gene" downshifts 3138407 /Source="Nicolas_upshifts" /id="D1779" /incds=0 /nref=53 /ntot=250 /MaxReadThrough="3.27525" /MaxDrop="4.21929" /score="-0.306638574" /energy="-13.4" /TU="U2697" /idTUdmin="U2697" /TUdmin="-418" /isTUend="FALSE" /label="downshifts" CDS complement(3138438..3139406) /gene="epsO" /locus_tag="BSU_34220" /old_locus_tag="BSU34220" /EC_number="2.-.-.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1097084, 115661000, 20720312, 23378512; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyruvyl transferase for matrix biofilm formation" /protein_id="NP_391302.1" /db_xref="EnsemblGenomes-Gn:BSU34220" /db_xref="EnsemblGenomes-Tr:CAB15427" /db_xref="GOA:P71065" /db_xref="InterPro:IPR007345" /db_xref="SubtiList:BG11874" /db_xref="UniProtKB/Swiss-Prot:P71065" /translation="MDSKHSMISLKQKLSGLLDVIPKQSEIIYADYPLYGNVGDLFIM KGTEAFFKEHGIRVRKRWNPDNFPIGRKLDPNLIIVCQGGGNFGDLYPYYQGFREKIV QTYPNHKIVILPQSIYFQNKDNLKRTAEIFSKHANLHIMTREKASYATAQAYFTTNHI QLLPDMAHQLFPVIPTQQPSNQKLRFIRTDHEANQALQEHAEAESYDWRTVLSASDRR TIAFLQTLNVLNKKAGNPLPIAYIWEKYSDYIVQKAIRFFSRYESVETSRLHGHILSS LLQKENTVIDNSYGKNANYFHTWMEGVPSTRLIQHASKKENLPAHM*" /label="epsO CDS" gene complement(3138438..3139406) /gene="epsO" /locus_tag="BSU_34220" /old_locus_tag="BSU34220" /label="epsO gene" CDS complement(3139385..3140551) /gene="epsN" /locus_tag="BSU_34230" /old_locus_tag="BSU34230" /EC_number="2.6.1.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15661000, 20720312, 23378512, 27084765, 27897378; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aminotransferase involved in biofilm matrix formation" /protein_id="NP_391303.2" /db_xref="EnsemblGenomes-Gn:BSU34230" /db_xref="EnsemblGenomes-Tr:CAB15428" /db_xref="GOA:Q795J3" /db_xref="InterPro:IPR000653" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG11873" /db_xref="UniProtKB/Swiss-Prot:Q795J3" /translation="MHKKIYLSPPHMSGREQHYISEAFRSNWIAPLGPLVNSFEEQLA ERVGVKAAAAVGSGTAAIHLALRLLEVKEGDSVFCQSFTFVATANPILYEKAVPVFID SEPDTWNMSPTALERALEEAKRNGTLPKAVIAVNLYGQSAKMDEIVSLCDAYGVPVIE DAAESLGTVYKGKQSGTFGRFGIFSFNGNKIITTSGGGMLVSNDEAAIEKARFLASQA REPAVHYQHSEIGHNYRLSNILAGVGIAQLEVLDERVEKRRTIFTRYKNALGHLDGVR FMPEYAAGVSNRWLTTLTLDNGLSPYDIVQRLAEENIEARPLWKPLHTQPLFDPALFY SHEDTGSVCEDLFKRGICLPSGSNMTEDEQGRVIEVLLHLFHTVEVKKWTASIR*" /label="epsN CDS" gene complement(3139385..3140551) /gene="epsN" /locus_tag="BSU_34230" /old_locus_tag="BSU34230" /label="epsN gene" CDS complement(3140556..3141206) /gene="epsM" /locus_tag="BSU_34240" /old_locus_tag="BSU34240" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15661000, 27897378; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative O-acetyltransferase involved in biofilmmatrix formation" /protein_id="NP_391304.1" /db_xref="EnsemblGenomes-Gn:BSU34240" /db_xref="EnsemblGenomes-Tr:CAB15429" /db_xref="GOA:P71063" /db_xref="InterPro:IPR001451" /db_xref="InterPro:IPR011004" /db_xref="InterPro:IPR018357" /db_xref="InterPro:IPR020019" /db_xref="SubtiList:BG11872" /db_xref="UniProtKB/Swiss-Prot:P71063" /translation="MKNVAIVGDGGHGKVIRELINARSDTRLAAVLDDKFKTFEGGKE WYTGPPKAVTELRRLIPDVLFLIAVGNNSVRKQLAERLGLGKDDFITLIHPSAIVSKS AVIGEGTVIMAGAIIQADARIGAHCIINTGAVAEHDNQISDYVHLSPRATLSGAVSVQ EGAHVGTGASVIPQIIIGAWSIVGAGSAVIRSIPDRVTAAGAPARIISSIQTSNKG*" /label="epsM CDS" gene complement(3140556..3141206) /gene="epsM" /locus_tag="BSU_34240" /old_locus_tag="BSU34240" /label="epsM gene" CDS complement(3141203..3141811) /gene="epsL" /locus_tag="BSU_34250" /old_locus_tag="BSU34250" /EC_number="2.7.-.-" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15175311, 15661000, 23378512; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphotransferase involved in extracellular matrix synthesis" /protein_id="NP_391305.1" /db_xref="EnsemblGenomes-Gn:BSU34250" /db_xref="EnsemblGenomes-Tr:CAB15430" /db_xref="GOA:P71062" /db_xref="InterPro:IPR003362" /db_xref="SubtiList:BG11871" /db_xref="UniProtKB/Swiss-Prot:P71062" /translation="MILKRLFDLTAAIFLLCCTSVIILFTIAVVRLKIGSPVFFKQVR PGLHGKPFTLYKFRTMTDERDSKGNLLPDEVRLTKTGRLIRKLSIDELPQLLNVLKGD LSLVGPRPLLMDYLPLYTEKQARRHEVKPGITGWAQINGRNAISWEKKFELDVWYVDN WSFFLDLKILCLTVRKVLVSEGIQQTNHVTAERFTGSGDVSS*" /label="epsL CDS" gene complement(3141203..3141811) /gene="epsL" /locus_tag="BSU_34250" /old_locus_tag="BSU34250" /label="epsL gene" CDS complement(3141808..3143325) /gene="epsK" /locus_tag="BSU_34265" /old_locus_tag="BSU34265" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15175311, 15661000, 15849754, 16850406, 26078454, 27897378; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative extracellular matrix component exporter; putative cyclic di-GMP receptor" /protein_id="YP_003097789.1" /db_xref="EnsemblGenomes-Gn:BSU34265" /db_xref="EnsemblGenomes-Tr:CAX52695" /db_xref="GOA:P71060" /db_xref="InterPro:IPR002797" /db_xref="InterPro:IPR029303" /db_xref="UniProtKB/Swiss-Prot:P71060" /translation="MKFTINFSANLTAFLLSVFLSVWMTPFIVKTLGVEAFGFVHLTQ NVINYFSVITVALSSVVVRFFSVAAHRGEREKANAYISNYLAASVLISLLLLLPLAGS AFFIDRVMNVPQALLADVRLSILIGSVLFILTFLMAGFGAAPFYANRLYITSSIQAVQ MLIRVLSVLLLFACFAPKIWQIQLAALAGAVIASVLSFYFFKKLIPWFSFRMKDLSFR TSKELFQAGAWSSVNQIGVLLFLQIDLLTANLMLGASASGKYAAIIQFPLLLRSLAGT VASLFAPIMTSYYSKGDMEGLMNYANKAVRLNGLLLALPAALLGGLAGPFLTIWLGPS FSTIAPLLFIHAGYLVVSLAFMPLFYIWTAFNQQKTPAIVTLLLGAVNVVLAVTLSGP AHLGLYGITLAGAISLILKNAIFTPLYVSRITGYKKHVFLKGIIGPLSAAVFAWTVCK AIQFIVKIDSWPSLIATGVTVSFCYAVFAFMLVCTKEERQLVLKRFRKTKGAVNL*" /label="epsK CDS" gene complement(3141808..3143325) /gene="epsK" /locus_tag="BSU_34265" /old_locus_tag="BSU34265" /label="epsK gene" CDS complement(3143322..3144356) /gene="epsJ" /locus_tag="BSU_34280" /old_locus_tag="BSU34280" /EC_number="2.4.-.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15661000, 20720312, 26078454, 27897378; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyl transferase involved in biofilm matrix formation" /protein_id="NP_391308.1" /db_xref="EnsemblGenomes-Gn:BSU34280" /db_xref="EnsemblGenomes-Tr:CAB15433" /db_xref="GOA:P71059" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG11868" /db_xref="UniProtKB/Swiss-Prot:P71059" /translation="MIPLVSIIVPMYNVEPFIEECIDSLLRQTLSDIEIILVNDGTPD RSGEIAEDYAKRDARIRVIHQANGGLSSARNTGIKAARGTYIGFVDGDDYVSSAMFQR LTEEAEQNQLDIVGCGFYKQSSDRRTYVPPQLEANRVLTKPEMTEQLKHAHETRFIWY VWRYLYRRELFERANLLFDEDIRFAEDSPFNLSAFREAERVKMLDEGLYIYRENPNSL TEIPYKPAMDEHLQKQYQAKIAFYNHYGLAGACKEDLNVYICRHQLPMLLANACASPN SPKDIKKKIRQILSYDMVRQAVRHTPFQHEKLLRGERLVLALCKWRLTFLIKLFFEQR GTMKGSAKQA*" /label="epsJ CDS" gene complement(3143322..3144356) /gene="epsJ" /locus_tag="BSU_34280" /old_locus_tag="BSU34280" /label="epsJ gene" CDS complement(3144353..3145429) /gene="epsI" /locus_tag="BSU_34290" /old_locus_tag="BSU34290" /EC_number="2.-.-.-" /function="16.8: Protect" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15173185, 15661000, 20720312, 26078454; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative polysaccharide pyruvyl transferase involved in biofilm matrix formation" /protein_id="NP_391309.1" /db_xref="EnsemblGenomes-Gn:BSU34290" /db_xref="EnsemblGenomes-Tr:CAB15434" /db_xref="GOA:P71058" /db_xref="InterPro:IPR007345" /db_xref="SubtiList:BG11867" /db_xref="UniProtKB/Swiss-Prot:P71058" /translation="MSLQSLKINFAEWLLLKVKYPSQYWLGAADQPVKAAAHQKKIIL TLLPSHDNLGDHAIAYASKAFLEQEYPDFDIVEVDMKDIYKSAKSLIRSRHPEDMVFI IGGGNMGDLYRYEEWTRRFIIKTFHDYRVVQLPATAHFSDTKKGRKELKRAQKIYNAH PGLLLMARDETTYQFMKQHFQEKTILKQPDMVLYLDRSKAPAEREGVYMCLREDQESV LQEEQRNRVKAALCEEFGEIKSFTTTIGRRVSRDTREHELEALWSKLQSAEAVVTDRL HGMIFCALTGTPCVVIRSFDHKVMEGYQWLKDIPFMKLIEHPEPERVTAAVNELLTKE TSRAGFPRDVYFKGLRDKISGEAQ*" /label="epsI CDS" gene complement(3144353..3145429) /gene="epsI" /locus_tag="BSU_34290" /old_locus_tag="BSU34290" /label="epsI gene" CDS complement(3145434..3146468) /gene="epsH" /locus_tag="BSU_34300" /old_locus_tag="BSU34300" /EC_number="2.-.-.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15083514, 15661000; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase involved in biofilmformation" /protein_id="NP_391310.1" /db_xref="EnsemblGenomes-Gn:BSU34300" /db_xref="EnsemblGenomes-Tr:CAB15435" /db_xref="GOA:P71057" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG11866" /db_xref="UniProtKB/Swiss-Prot:P71057" /translation="METPAVSLLVAVYNTETYIRTCLESLRNQTMDNIEIIIVNDGSA DASPDIAEEYAKMDNRFKVIHQENQGLGAVRNKGIEAARGEFIAFIDSDDWIEPDYCE QMLRTAGDETDLVICNYAAEFEDTGKTMDSDIAQTYQDQPKEHYIKALFEGKVRGFSW NKLYRRSMIEAHRLSFPLRGELEHVEDQFFSFRAHFFARSVSYVKTPLYHYRIHLSSI VQRYQKKLFESGLALYETNAAFLQENNKLEEYRKELDTFIVLHSSICMLNEWKTSGSR RLFEKLRNVGVICADPVFQESLSKTGTAPFDAKRSCLLLMAKYRMIPFVAMASAVYQR VIEYKMRNRG*" /label="epsH CDS" gene complement(3145434..3146468) /gene="epsH" /locus_tag="BSU_34300" /old_locus_tag="BSU34300" /label="epsH gene" CDS complement(3146493..3147596) /gene="epsG" /locus_tag="BSU_34310" /old_locus_tag="BSU34310" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15175311, 15661000, 15849754, 16850406, 22451411" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15175311, 15661000, 15849754, 16850406, 22451411; Product type f: factor" /codon_start=1 /transl_table=11 /product="biofilm extracellular matrix formation chain-length determining factor" /protein_id="NP_391311.1" /db_xref="EnsemblGenomes-Gn:BSU34310" /db_xref="EnsemblGenomes-Tr:CAB15436" /db_xref="GOA:P71056" /db_xref="SubtiList:BG11865" /db_xref="UniProtKB/Swiss-Prot:P71056" /translation="MIVYAVNMGIVFIWSWFAKMCGGRDDSLATGYRPNKLLIWIPLA SLVLVSGLRYRVGTDFQTYTLLYELAGDYQNVWQIFGFGTAKTATDPGFTALLWLMNF ITEDPQIMYFTVAVVTYSFIMKTLADYGRPFELSVFLFLGTFHYYASFNGIRQYMVAA VLFWAIRYIISGNWKRYFLIVLVSSLFHSSALIMIPVYFIVRRKAWSPAIFGLSALFL GMTFLYQKFISVFVVVLENSSYSHYEKWLMTNTNGMNVIKIAVLVLPLFLAFCYKERL RSLWPQIDIVVNLCLLGFLFGLLATKDVIFARFNIYFGLYQMILVPYFVRIFDEKSNA LIYIAIVVCYFLYSYLLMPVDSSVLPYRTIFSR*" /label="epsG CDS" gene complement(3146493..3147596) /gene="epsG" /locus_tag="BSU_34310" /old_locus_tag="BSU34310" /label="epsG gene" CDS complement(3147593..3148747) /gene="epsF" /locus_tag="BSU_34320" /old_locus_tag="BSU34320" /EC_number="2.-.-.-" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15175311, 15661000, 22451411; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase involved in matrix formation (chain-length determination)" /protein_id="NP_391312.1" /db_xref="EnsemblGenomes-Gn:BSU34320" /db_xref="EnsemblGenomes-Tr:CAB15437" /db_xref="GOA:P71055" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR028098" /db_xref="SubtiList:BG11864" /db_xref="UniProtKB/Swiss-Prot:P71055" /translation="MNSSQKRVLHVLSGMNRGGAETMVMNLYRKMDKSKVQFDFLTYR NDPCAYDEEILSLGGRLFYVPSIGQSNPLTFVRNVRNAIKENGPFSAVHAHTDFQTGF IALAARLAGVPVRVCHSHNTSWKTGFNWKDRLQLLVFRRLILANATALCACGEDAGRF LFGQSNMERERVHLLPNGIDLELFAPNGQAADEEKAARGIAADRLIIGHVARFHEVKN HAFLLKLAAHLKERGIRFQLVLAGDGPLCGEIEEEARQQNLLSDVLFLGTEERIHELM RTFDVFVMPSLYEGLPVVLVEAQASGLPCIISDSITEKVDAGLGLVTRLSLSEPISVW AETIARAAAAGRPKREFIKETLAQLGYDAQQNVGALLNVYNISTEKDHNR*" /label="epsF CDS" gene complement(3147593..3148747) /gene="epsF" /locus_tag="BSU_34320" /old_locus_tag="BSU34320" /label="epsF gene" CDS complement(3148740..3149576) /gene="epsE" /locus_tag="BSU_34330" /old_locus_tag="BSU34330" /EC_number="2.-.-.-" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15175311, 15661000, 21170308, 22720735, 23480406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15175311, 15661000, 21170308, 22720735, 23480406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional flagellar clutch and glycosyltransferase acting during biofilm formation" /protein_id="NP_391313.2" /db_xref="EnsemblGenomes-Gn:BSU34330" /db_xref="EnsemblGenomes-Tr:CAB15438" /db_xref="GOA:P71054" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG11863" /db_xref="UniProtKB/Swiss-Prot:P71054" /translation="MNSGPKVSVIMGIYNCERTLAESIESILSQSYKNWELILCDDAS TDGTLRIAKQYAAHYSDRIKLIQNKTNKRLAASLNHCLSHATGDYIARQDGDDLSFPR RLEKQVAFLEKHRHYQVVGTGMLVFDEFGVRGARILPSVPEPGIMAKGTPFCHGTIMM RASAYRTLKGYRSVRRTRRMEDIDLWLRFFEEGFRGYNLQEALYKVREDSDAFKRRSF TYSIDNAILVYQACRRLKLPLSDYIYIAKPLIRAFMPAAVMNRYHKKRVMNQKEGLVK HE*" /label="epsE CDS" gene complement(3148740..3149576) /gene="epsE" /locus_tag="BSU_34330" /old_locus_tag="BSU34330" /label="epsE gene" CDS complement(3149573..3150718) /gene="epsD" /locus_tag="BSU_34340" /old_locus_tag="BSU34340" /EC_number="2.4.-.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15175311, 15661000, 23378512, 26299781; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative extracellular matrix glycosyltransferase" /protein_id="NP_391314.1" /db_xref="EnsemblGenomes-Gn:BSU34340" /db_xref="EnsemblGenomes-Tr:CAB15439" /db_xref="GOA:P71053" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR028098" /db_xref="SubtiList:BG11862" /db_xref="UniProtKB/Swiss-Prot:P71053" /translation="MTKKILFCATVDYHFKAFHLPYFKWFKQMGWEVHVAANGQTKLP YVDEKFSIPIRRSPFDPQNLAVYRQLKKVIDTYEYDIVHCHTPVGGVLARLAARQARR HGTKVLYTAHGFHFCKGAPMKNWLLYYPVEKWLSAYTDCLITINEEDYIRAKGLQRPG GRTQKIHGIGVNTERFRPVSPIEQQRLREKHGFREDDFILVYPAELNLNKNQKQLIEA AALLKEKIPSLRLVFAGEGAMEHTYQTLAEKLGASAHVCFYGFCSDIHELIQLADVSV ASSIREGLGMNVLEGMAAEQPAIATDNRGHREIIRDGENGFLIKIGDSAAFARRIEQL YHKPELCRKLGQEGRKTALRFSEARTVEEMADIYSAYMDMDTKEKSV*" /label="epsD CDS" gene complement(3149573..3150718) /gene="epsD" /locus_tag="BSU_34340" /old_locus_tag="BSU34340" /label="epsD gene" CDS complement(3150730..3152526) /gene="epsC" /locus_tag="BSU_34350" /old_locus_tag="BSU34350" /EC_number="5.1.3.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15661000, 23378512, 27655338; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative UDP-sugar epimerase involved in biofilmmatrix formation" /protein_id="NP_391315.1" /db_xref="EnsemblGenomes-Gn:BSU34350" /db_xref="EnsemblGenomes-Tr:CAB15440" /db_xref="GOA:P71052" /db_xref="InterPro:IPR003869" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11861" /db_xref="UniProtKB/Swiss-Prot:P71052" /translation="MIIALDTYLVLNSVIAGYQFLKDSYQFYDSGALLLTAVSLLLSY HVCAFLFNQYKQVWTYTGLGELIVLLKGITLSAAVTGVIQYAVYHTMFFRLLTACWVL QLLSIGGTRILSRVLNESIRKKRCASSRALIIGAGSGGTLMVRQLLSKDEPDIIPVAF IDDDQTKHKLEIMGLPVIGGKESIMPAVQKLKINYIIIAIPSLRTHELQVLYKECVRT GVSIKIMPHFDEMLLGTRTAGQIRDVKAEDLLGRKPVTLDTSEISNRIKGKTVLVTGA GGSIGSEICRQISAFQPKEIILLGHGENSIHSIYTELNGRFGKHIVFHTEIADVQDRD KMFTLMKKYEPHVVYHAAAHKHVPLMEHNPEEAVKNNIIGTKNVAEAADMSGTETFVL ISSDKAVNPANVMGATKRFAEMIIMNLGKVSRTKFVAVRFGNVLGSRGSVIPIFKKQI EKGGPVTVTHPAMTRYFMTIPEASRLVIQAGALAKGRQIFVLDMGEPVKIVDLAKNLI HLSGYTTEQVPIEFTGIRPGEKMYEELLNKNEVHAEQIFPKIHIGKAVDGDWPVLMRF IEDFHELPEADLRARLFAAINTSEEMTAASVH*" /label="epsC CDS" gene complement(3150730..3152526) /gene="epsC" /locus_tag="BSU_34350" /old_locus_tag="BSU34350" /label="epsC gene" S_feature complement(3152527..3152586) /Source="Nicolas_S_feature" /locus_tag="new_3528204_3528263_c" /HighExp="LoTm, G/S, M9-tran, BMM, MG 150, S3, S2, S4, aero, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig="0.79" /TUlongSig="NA" /TUlongPSig="NA" /label="S1312" promotor_-10 complement(3152560..3152578) /Source="Nicolas_upshift_promotors" /id="U2699" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.79020979020979" /psig="0.79020979020979" /xcortree=2767 /SigmaFactorBS="atacataggacgtattgtcggtttagctgctgccgatttttt ggagagACGAAAAccgccgcagctaaACCGATAAAAGAATTAGGGgggaaaaggttga g" /listShort="S1312, epsC, epsD, epsE, epsF, epsG, epsH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3152586) /Source="Nicolas_upshifts" /id="U2699" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.79020979020979" /psig="0.79020979020979" /xcortree=2767 /SigmaFactorBS="atacataggacgtattgtcggtttagctgctgccgatttttt ggagagACGAAAAccgccgcagctaaACCGATAAAAGAATTAGGGgggaaaaggttga g" /listShort="S1312, epsC, epsD, epsE, epsF, epsG, epsH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3152592..3152598) /Source="Nicolas_upshift_promotors" /id="U2699" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.79020979020979" /psig="0.79020979020979" /xcortree=2767 /SigmaFactorBS="atacataggacgtattgtcggtttagctgctgccgatttttt ggagagACGAAAAccgccgcagctaaACCGATAAAAGAATTAGGGgggaaaaggttga g" /listShort="S1312, epsC, epsD, epsE, epsF, epsG, epsH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3152785..3153468) /gene="epsB" /locus_tag="BSU_34360" /old_locus_tag="BSU34360" /EC_number="2.7.10.2" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15661000, 15741737, 24493247, 26283769, 28950882" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15661000, 15741737, 24493247, 26283769, 28950882; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein tyrosine kinase involved in biofilm matrix formation" /protein_id="NP_391316.1" /db_xref="EnsemblGenomes-Gn:BSU34360" /db_xref="EnsemblGenomes-Tr:CAB15441" /db_xref="GOA:P71051" /db_xref="InterPro:IPR005702" /db_xref="InterPro:IPR025669" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11860" /db_xref="UniProtKB/Swiss-Prot:P71051" /translation="MIFRKKKARRGLAQISVLHNKSVVAEQYRTIRTNIEFSSVQTNL RSILVTSSVPGEGKSFSAANLAAVFAQQQEKKVLLVDADLRKPTINQTFQVDNVTGLT NVLVGNASLSETVQKTPIDNLYVLTSGPTPPNPAELLSSKAMGDLISEIYEQFSLVIF DSPPLLAVADAQILANQTDGSVLVVLSGKTKTDTVLKAKDALEQSNAKLLGALLNKKK MKKSEHYSY*" /label="epsB CDS" gene complement(3152785..3153468) /gene="epsB" /locus_tag="BSU_34360" /old_locus_tag="BSU34360" /label="epsB gene" CDS complement(3153474..3154178) /gene="epsA" /locus_tag="BSU_34370" /old_locus_tag="BSU34370" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12970183, 15661000, 23378512, 26283769, 28950882; Product type r : regulator" /codon_start=1 /transl_table=11 /product="modulator of protein tyrosine kinase EpsB involved in biofilm matrix formation" /protein_id="NP_391317.1" /db_xref="EnsemblGenomes-Gn:BSU34370" /db_xref="EnsemblGenomes-Tr:CAB15442" /db_xref="GOA:P71050" /db_xref="InterPro:IPR003856" /db_xref="SubtiList:BG11859" /db_xref="UniProtKB/Swiss-Prot:P71050" /translation="MNENMSFKELYAIVRHRFVLILLITIGVTLIMGFVQFKVISPTY QASTQVLVHESDGEENSNLSDIQRNLQYSSTFQSIMKSTALMEEVKAELHLSESASSL KGKVVTSSENESEIINVAVQDHDPAKAAEIANTLVNKFEKEVDERMNVQGVHILSEAK ASESPMIKPARLRNMVMAFGAAVMGGITLAFFLHFLDDTCKSARQLSERTGLPCLGSV PDVHKGRNRGIKHFGE*" /label="epsA CDS" gene complement(3153474..3154178) /gene="epsA" /locus_tag="BSU_34370" /old_locus_tag="BSU34370" /label="epsA gene" upshifts 3154160 /Source="Nicolas_upshifts" /id="U2700" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1024 /SigmaFactorBS="cgattgtgatgagcagaatcagcacgaatctgtgtctgacaa tCgcatataattctttgaaacTCATATTCTCATTCATGTAttcatagccttcagcctt c" /listShort="slrR" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3154163..3154181 /Source="Nicolas_upshift_promotors" /id="U2700" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1024 /SigmaFactorBS="cgattgtgatgagcagaatcagcacgaatctgtgtctgacaa tCgcatataattctttgaaacTCATATTCTCATTCATGTAttcatagccttcagcctt c" /listShort="slrR" /GFF_Attribute="listLong" /label="promotor_-10" S_feature complement(3154179..3154236) /Source="Nicolas_S_feature" /locus_tag="new_3529856_3529913_c" /HighExp="LoTm, BT, S3, G/S, BMM, M9-tran, S4, aero, T1.0H, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.952" /TUlongSig="NA" /TUlongPSig="NA" /label="S1313" promotor_-10 complement(3154232..3154251) /Source="Nicolas_upshift_promotors" /id="U2701" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.441558441558442" /psig="0.952047952047952" /xcortree=2770 /SigmaFactorBS="aagagaacttattggcttattttgcAATTTTTAaataataac gtttTCTTTTATAATCCAATCATTaacagaaaggggcgcgggaagccagccgcgggaa g" /listShort="S1313, epsA, epsB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3154237) /Source="Nicolas_upshifts" /id="U2701" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.441558441558442" /psig="0.952047952047952" /xcortree=2770 /SigmaFactorBS="aagagaacttattggcttattttgcAATTTTTAaataataac gtttTCTTTTATAATCCAATCATTaacagaaaggggcgcgggaagccagccgcgggaa g" /listShort="S1313, epsA, epsB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3154265..3154272) /Source="Nicolas_upshift_promotors" /id="U2701" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.441558441558442" /psig="0.952047952047952" /xcortree=2770 /SigmaFactorBS="aagagaacttattggcttattttgcAATTTTTAaataataac gtttTCTTTTATAATCCAATCATTaacagaaaggggcgcgggaagccagccgcgggaa g" /listShort="S1313, epsA, epsB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3154354..3154359 /Source="Nicolas_upshift_promotors" /id="U2702" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.464535464535465" /psig="0.995004995004995" /xcortree=2771 /SigmaFactorBS="cctctaatttactgcacttcccttattattttaaATTTTAta aagaacgaaaaaTTCCTTATAATGAACGAAATaacgacaggaatagaggagaatttca t" /listShort="slrR" /listLong="pnbA" /label="promotor_-35" promotor_-10 3154374..3154393 /Source="Nicolas_upshift_promotors" /id="U2702" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.464535464535465" /psig="0.995004995004995" /xcortree=2771 /SigmaFactorBS="cctctaatttactgcacttcccttattattttaaATTTTAta aagaacgaaaaaTTCCTTATAATGAACGAAATaacgacaggaatagaggagaatttca t" /listShort="slrR" /listLong="pnbA" /label="promotor_-10" upshifts 3154380 /Source="Nicolas_upshifts" /id="U2702" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.464535464535465" /psig="0.995004995004995" /xcortree=2771 /SigmaFactorBS="cctctaatttactgcacttcccttattattttaaATTTTAta aagaacgaaaaaTTCCTTATAATGAACGAAATaacgacaggaatagaggagaatttca t" /listShort="slrR" /listLong="pnbA" /label="upshifts" CDS 3154424..3154882 /gene="slrR" /locus_tag="BSU_34380" /old_locus_tag="BSU34380" /function="16.5: Explore" /function="16.13: Shape" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18430133, 18647168, 20923420, 28546427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18430133, 18647168, 20923420, 28546427; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of autolysin genes (biofilm formation)" /protein_id="NP_391318.1" /db_xref="EnsemblGenomes-Gn:BSU34380" /db_xref="EnsemblGenomes-Tr:CAB15443" /db_xref="GOA:P71049" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010981" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR036281" /db_xref="SubtiList:BG11858" /db_xref="UniProtKB/Swiss-Prot:P71049" /translation="MIGRIIRLYRKRKGYSINQLAVESGVSKSYLSKIERGVHTNPSV QFLKKVSATLEVELTELFDAETMMYEKISGGEEEWRVHLVQAVQAGMEKEELFTFTNR LKKEQPETASYRNRKLTESNIEEWKALMAEAREIGLSVHEVKSFLKTKGR*" /label="slrR CDS" gene 3154424..3154882 /gene="slrR" /locus_tag="BSU_34380" /old_locus_tag="BSU34380" /label="slrR gene" promotor_-35 3154904..3154907 /Source="Nicolas_upshift_promotors" /id="U2703" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.446553446553447" /psig="0.888111888111888" /xcortree=3178 /SigmaFactorBS="aaatcctttttaaaaacaaagggaagatgatgatcggttaaa gggctaacgTTCGcatctataggggaaatCTGTTTATAATGGGGGAAAaagggagaga a" /listShort="pnbA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3154913 /Source="Nicolas_upshifts" /id="U2703" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.446553446553447" /psig="0.888111888111888" /xcortree=3178 /SigmaFactorBS="aaatcctttttaaaaacaaagggaagatgatgatcggttaaa gggctaacgTTCGcatctataggggaaatCTGTTTATAATGGGGGAAAaagggagaga a" /listShort="pnbA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3154924..3154942 /Source="Nicolas_upshift_promotors" /id="U2703" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.446553446553447" /psig="0.888111888111888" /xcortree=3178 /SigmaFactorBS="aaatcctttttaaaaacaaagggaagatgatgatcggttaaa gggctaacgTTCGcatctataggggaaatCTGTTTATAATGGGGGAAAaagggagaga a" /listShort="pnbA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3154958..3156427 /gene="pnbA" /locus_tag="BSU_34390" /old_locus_tag="BSU34390" /EC_number="3.1.1.1" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:7828905, 15138843" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7828905, 15138843; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="para-nitrobenzyl esterase (intracellular esterase B)" /protein_id="NP_391319.1" /db_xref="EnsemblGenomes-Gn:BSU34390" /db_xref="EnsemblGenomes-Tr:CAB15444" /db_xref="GOA:P37967" /db_xref="InterPro:IPR000997" /db_xref="InterPro:IPR002018" /db_xref="InterPro:IPR019819" /db_xref="InterPro:IPR019826" /db_xref="InterPro:IPR029058" /db_xref="PDB:1C7I" /db_xref="PDB:1C7J" /db_xref="PDB:1QE3" /db_xref="SubtiList:BG11844" /db_xref="UniProtKB/Swiss-Prot:P37967" /translation="MTHQIVTTQYGKVKGTTENGVHKWKGIPYAKPPVGQWRFKAPEP PEVWEDVLDATAYGSICPQPSDLLSLSYTELPRQSEDCLYVNVFAPDTPSKNLPVMVW IHGGAFYLGAGSEPLYDGSKLAAQGEVIVVTLNYRLGPFGFLHLSSFNEAYSDNLGLL DQAAALKWVRENISAFGGDPDNVTVFGESAGGMSIAALLAMPAAKGLFQKAIMESGAS RTMTKEQAASTSAAFLQVLGINEGQLDKLHTVSAEDLLKAADQLRIAEKENIFQLFFQ PALDPKTLPEEPEKAIAEGAASGIPLLIGTTRDEGYLFFTPDSDVHSQETLDAALEYL LGKPLAEKVADLYPRSLESQIHMMTDLLFWRPAVAYASAQSHYAPVWMYRFDWHPKKP PYNKAFHALELPFVFGNLDGLERMAKAEITDEVKQLSHTIQSAWITFAKTGNPSTEAV NWPAYHEETRETLILDSEITIENDPESEKRQKLFPSKGE*" /label="pnbA CDS" gene 3154958..3156427 /gene="pnbA" /locus_tag="BSU_34390" /old_locus_tag="BSU34390" /label="pnbA gene" downshifts 3156404 /Source="Nicolas_upshifts" /id="D1780" /incds=0 /nref=4 /ntot=150 /MaxReadThrough="3.66738" /MaxDrop="2.70933" /score="-9.70074934" /energy="-12.2" /TU="U2703" /idTUdmin="U2703" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" CDS 3156430..3156621 /locus_tag="BSU_34399" /old_locus_tag="BSU34399" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514003.1" /translation="MGKTGYIGAAIVVAACIIILSAVVCLRDTVYYQPMRWTGIILFF AGIVMVPAYSAKRKPGKEK*" /label="hypothetical protein CDS" gene 3156430..3156621 /locus_tag="BSU_34399" /old_locus_tag="BSU34399" /label="gene" downshifts 3156600 /Source="Nicolas_upshifts" /id="D1781" /incds=0 /nref=24 /ntot=181 /MaxReadThrough="-0.096" /MaxDrop="4.20686" /score="34.8993337" /energy="-22.3" /TU="NA" /idTUdmin="U2703" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(3156648..3157133) /gene="padC" /locus_tag="BSU_34400" /old_locus_tag="BSU34400" /EC_number="4.1.1.102" /EC_number="4.1.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9546183, 12903944, 17295427, 18326577, 21685295, 26658822" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9546183, 12903944, 17295427, 18326577, 21685295, 26658822; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="phenolic acid decarboxylase" /protein_id="NP_391320.1" /db_xref="EnsemblGenomes-Gn:BSU34400" /db_xref="EnsemblGenomes-Tr:CAB15445" /db_xref="GOA:O07006" /db_xref="InterPro:IPR008729" /db_xref="InterPro:IPR012674" /db_xref="PDB:2P8G" /db_xref="PDB:4ALB" /db_xref="SubtiList:BG12433" /db_xref="UniProtKB/Swiss-Prot:O07006" /translation="MENFIGSHMIYTYENGWEYEIYIKNDHTIDYRIHSGMVAGRWVR DQEVNIVKLTEGVYKVSWTEPTGTDVSLNFMPNEKRMHGIIFFPKWVHEHPEITVCYQ NDHIDLMKESREKYETYPKYVVPEFAEITFLKNEGVDNEEVISKAPYEGMTDDIRAGR L*" /label="padC CDS" gene complement(3156648..3157133) /gene="padC" /locus_tag="BSU_34400" /old_locus_tag="BSU34400" /label="padC gene" CDS complement(3157156..3157467) /gene="yveG" /locus_tag="BSU_34410" /old_locus_tag="BSU34410" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /db_xref="EnsemblGenomes-Gn:BSU34410" /db_xref="EnsemblGenomes-Tr:CAB15446" /db_xref="GOA:O07005" /db_xref="InterPro:IPR011250" /db_xref="InterPro:IPR020915" /db_xref="PSEUDO:CAB15446.2" /db_xref="SubtiList:BG12432" /db_xref="UniProtKB/Swiss-Prot:O07005" /translation="MPGGADSQMIRANGRTDLSARYVIETADHELIYIENNGIRQVSK PFRKQAAAGEIIEPEHVYFRTVPTFETGSEVYQWLHDRLFIGSAERTPDYVLLDIYEV Q*" /label="yveG CDS" gene complement(3157156..3157467) /gene="yveG" /locus_tag="BSU_34410" /old_locus_tag="BSU34410" /pseudo /label="yveG gene" CDS complement(3157519..3157611) /gene="yveF" /locus_tag="BSU_34420" /old_locus_tag="BSU34420" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="EnsemblGenomes-Gn:BSU34420" /db_xref="EnsemblGenomes-Tr:CAB15447" /db_xref="PSEUDO:CAB15447.1" /db_xref="SubtiList:BG12431" /db_xref="UniProtKB/Swiss-Prot:O07004" /translation="MKKPVLKPFASLEIKVDPPITIGETSLGLR*" /label="yveF CDS" gene complement(3157519..3157611) /gene="yveF" /locus_tag="BSU_34420" /old_locus_tag="BSU34420" /pseudo /label="yveF gene" promotor_-10 complement(3157651..3157670) /Source="Nicolas_upshift_promotors" /id="U2704" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.66033966033966" /psig=1 /xcortree=3185 /SigmaFactorBS="ctgtcttcaaacagtccttgtttttttatgttcctatTGTTT GACagttaactgcaatGGTGTTAAAGTGAACATGTAaatagttacatgattttttctg a" /listShort="yveF, yveG, padC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3157668) /Source="Nicolas_upshifts" /id="U2704" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.66033966033966" /psig=1 /xcortree=3185 /SigmaFactorBS="ctgtcttcaaacagtccttgtttttttatgttcctatTGTTT GACagttaactgcaatGGTGTTAAAGTGAACATGTAaatagttacatgattttttctg a" /listShort="yveF, yveG, padC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3157684..3157691) /Source="Nicolas_upshift_promotors" /id="U2704" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.66033966033966" /psig=1 /xcortree=3185 /SigmaFactorBS="ctgtcttcaaacagtccttgtttttttatgttcctatTGTTT GACagttaactgcaatGGTGTTAAAGTGAACATGTAaatagttacatgattttttctg a" /listShort="yveF, yveG, padC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3157742..3158425) /gene="racX" /locus_tag="BSU_34430" /old_locus_tag="BSU34430" /EC_number="5.1.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9987136, 19063962, 2054383, 28894939" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9987136, 19063962, 2054383, 28894939; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous aminoacid racemase (prefers arginine, lysine and ornithine)" /protein_id="NP_391323.1" /db_xref="EnsemblGenomes-Gn:BSU34430" /db_xref="EnsemblGenomes-Tr:CAB15448" /db_xref="GOA:P32960" /db_xref="InterPro:IPR001920" /db_xref="InterPro:IPR004380" /db_xref="InterPro:IPR015942" /db_xref="InterPro:IPR018187" /db_xref="InterPro:IPR033134" /db_xref="SubtiList:BG10391" /db_xref="UniProtKB/Swiss-Prot:P32960" /translation="MIGILAGMGPKSTSPFIDKVIDYCQKLYGASNDIDYPHMMIYSC PTPFYADRPIDHDEMKKAIIDGAVKLEKTGVDFIALPCNTAHVYYEEIQQALSVPMLH IVEETIKEIPHPAKKAVVLGTEPTIQSAIYQKVLKGNGQEVIHKDHWQQAVNQLIAAI KQPNHMQHTQALWQTLYEEISQHADIIISACTDLNAVLDHIQSEIPIIDSSACLAKST VSTYLAYQS*" /label="racX CDS" gene complement(3157742..3158425) /gene="racX" /locus_tag="BSU_34430" /old_locus_tag="BSU34430" /label="racX gene" downshifts complement(3157760) /Source="Nicolas_upshifts" /id="D1782" /incds=0 /nref=122 /ntot=223 /MaxReadThrough="3.49026" /MaxDrop="5.32077" /score="5.15607483" /energy="-9.3" /TU="U2705" /idTUdmin="U2704" /TUdmin="-708" /isTUend="FALSE" /label="downshifts" CDS complement(3158441..3159796) /gene="pbpE" /locus_tag="BSU_34440" /old_locus_tag="BSU34440" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:7592498, 9987136, 12533473, 14679248, 19063962" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7592498, 9987136, 12533473, 14679248, 19063962; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="penicillin-binding protein 4*" /protein_id="NP_391324.1" /db_xref="EnsemblGenomes-Gn:BSU34440" /db_xref="EnsemblGenomes-Tr:CAB15449" /db_xref="GOA:P32959" /db_xref="InterPro:IPR001466" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR021860" /db_xref="SubtiList:BG10390" /db_xref="UniProtKB/Swiss-Prot:P32959" /translation="MKQNKRKHLQTLFETLGEKHQFNGTVLAAEGGDILYHHSFGYAE MTEKRPLKTNSLFELASLSKPFTALGIILLEEKGILGYEDKVDRWLPGFPYQGVTIRH LLNHTSGLPDYMGWFFANWDSHKIAVNQDIVDMLMNEGLSGYFEPNEGWMYSNTGYVL LAVIIEKASGMSYADFIKTSIFLPAGMNETRVYNRRLSPERIDHYAYGYVYDVHSETY VLPDELEETNYVVYLDGIQGDGTVNSVTSDLFRFDQALYQDDFISKASKESAFSPVRL NNGETIDYGFGWVLQNSPEKGRIVSHSGGWPGYSTMMIRYIDHRKTLIYLSNKEEDTE YEQAILKAAEHILFGQPYDVPERPADKKKKAIDTAIYSRYVGSYLLQDGTAAQVTTEN ERLYLEIAGQLRLELFPSSETRFFLRALSVEVEFTLGEDAAKSFILYEDGSEEEAVRT K*" /label="pbpE CDS" gene complement(3158441..3159796) /gene="pbpE" /locus_tag="BSU_34440" /old_locus_tag="BSU34440" /label="pbpE gene" promotor_-10 complement(3159808..3159823) /Source="Nicolas_upshift_promotors" /id="U2705" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1687 /SigmaFactorBS="gttaaaaaggatctctaactgaaggatttttcaaaatattTG AAACGTTAgtaggttagtaACGTACAGAGATATGGgaggtggaggaatgaagcagaat a" /listShort="pbpE, racX, yveF, yveG, padC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3159824) /Source="Nicolas_upshifts" /id="U2705" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1687 /SigmaFactorBS="gttaaaaaggatctctaactgaaggatttttcaaaatattTG AAACGTTAgtaggttagtaACGTACAGAGATATGGgaggtggaggaatgaagcagaat a" /listShort="pbpE, racX, yveF, yveG, padC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3159835..3159844) /Source="Nicolas_upshift_promotors" /id="U2705" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1687 /SigmaFactorBS="gttaaaaaggatctctaactgaaggatttttcaaaatattTG AAACGTTAgtaggttagtaACGTACAGAGATATGGgaggtggaggaatgaagcagaat a" /listShort="pbpE, racX, yveF, yveG, padC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3160098..3160105 /Source="Nicolas_upshift_promotors" /id="U2706" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.865134865134865" /psig="0.998001998001998" /xcortree=1753 /SigmaFactorBS="ttatgattttctatcaaacaaaagaggaaaatagacCAGTTG CAatccaaacgagagTCTAATAGAATGAGGTCGAAaagtaaatcgcgcgggtttgtta c" /listShort="S1314, sacB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3160119..3160138 /Source="Nicolas_upshift_promotors" /id="U2706" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.865134865134865" /psig="0.998001998001998" /xcortree=1753 /SigmaFactorBS="ttatgattttctatcaaacaaaagaggaaaatagacCAGTTG CAatccaaacgagagTCTAATAGAATGAGGTCGAAaagtaaatcgcgcgggtttgtta c" /listShort="S1314, sacB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3160122 /Source="Nicolas_upshifts" /id="U2706" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.865134865134865" /psig="0.998001998001998" /xcortree=1753 /SigmaFactorBS="ttatgattttctatcaaacaaaagaggaaaatagacCAGTTG CAatccaaacgagagTCTAATAGAATGAGGTCGAAaagtaaatcgcgcgggtttgtta c" /listShort="S1314, sacB" /GFF_Attribute="listLong" /label="upshifts" S_feature 3160144..3160334 /Source="Nicolas_S_feature" /locus_tag="new_3535821_3536011" /HighExp="G150, G180, G135, LBGexp, Mt0, Lbexp, LBGtran, dia0, GM 150, MG 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.219024" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1314" CDS 3160335..3161756 /gene="sacB" /locus_tag="BSU_34450" /old_locus_tag="BSU34450" /EC_number="2.4.1.10" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1400159, 11200435, 11320136, 11739774, 17704766, 15528654, 26600431" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1400159, 11200435, 11320136, 11739774, 17704766, 15528654, 26600431; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="levansucrase; levanase (moonlighting)" /protein_id="NP_391325.1" /db_xref="EnsemblGenomes-Gn:BSU34450" /db_xref="EnsemblGenomes-Tr:CAB15450" /db_xref="GOA:P05655" /db_xref="InterPro:IPR003469" /db_xref="InterPro:IPR023296" /db_xref="PDB:1OYG" /db_xref="PDB:1PT2" /db_xref="PDB:2VDT" /db_xref="PDB:3BYJ" /db_xref="PDB:3BYK" /db_xref="PDB:3BYL" /db_xref="PDB:3BYN" /db_xref="SubtiList:BG10388" /db_xref="UniProtKB/Swiss-Prot:P05655" /translation="MNIKKFAKQATVLTFTTALLAGGATQAFAKETNQKPYKETYGIS HITRHDMLQIPEQQKNEKYQVPEFDSSTIKNISSAKGLDVWDSWPLQNADGTVANYHG YHIVFALAGDPKNADDTSIYMFYQKVGETSIDSWKNAGRVFKDSDKFDANDSILKDQT QEWSGSATFTSDGKIRLFYTDFSGKHYGKQTLTTAQVNVSASDSSLNINGVEDYKSIF DGDGKTYQNVQQFIDEGNYSSGDNHTLRDPHYVEDKGHKYLVFEANTGTEDGYQGEES LFNKAYYGKSTSFFRQESQKLLQSDKKRTAELANGALGMIELNDDYTLKKVMKPLIAS NTVTDEIERANVFKMNGKWYLFTDSRGSKMTIDGITSNDIYMLGYVSNSLTGPYKPLN KTGLVLKMDLDPNDVTFTYSHFAVPQAKGNNVVITSYMTNRGFYADKQSTFAPSFLLN IKGKKTSVVKDSILEQGQLTVNK*" /label="sacB CDS" gene 3160335..3161756 /gene="sacB" /locus_tag="BSU_34450" /old_locus_tag="BSU34450" /label="sacB gene" downshifts 3161750 /Source="Nicolas_upshifts" /id="D1783" /incds=0 /nref=2 /ntot=27 /MaxReadThrough="2.33324" /MaxDrop="3.39023" /score="9.57663013" /energy="-7.7" /TU="NA" /idTUdmin="U2706" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 3161830..3163380 /gene="levB" /locus_tag="BSU_34460" /old_locus_tag="BSU34460" /EC_number="3.2.1.64" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11739774, 15528654, 26773563" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11739774, 15528654, 26773563; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endolevanase, selectively cleaves the (beta-2,6)fructosyl bonds" /protein_id="NP_391326.1" /db_xref="EnsemblGenomes-Gn:BSU34460" /db_xref="EnsemblGenomes-Tr:CAB15451" /db_xref="GOA:O07003" /db_xref="InterPro:IPR001362" /db_xref="InterPro:IPR013148" /db_xref="InterPro:IPR013189" /db_xref="InterPro:IPR013320" /db_xref="InterPro:IPR023296" /db_xref="SubtiList:BG12430" /db_xref="UniProtKB/Swiss-Prot:O07003" /translation="MNYIKAGKWLTVFLTFLGILLFIDLFPKEEHDQKTKSKQKPDYR AAYHFTTPDKWKNDPQKPIYFDGKYHYFYLYNRDYPKGNGTEWRHAVSEDLVHWTDEG VAIPKYTNPDGDIWTGSVVVDKENTAGFGKNALVAIVTQPSAKDKKQEQYLWYSTDKG KSFKFYSGNPVMPNPGTDDFRDPKVIWDDQDNKWVMVMAEGSKIGFYESDNLKDWHYT SGFFPEQAGMVECPDLYMMRASDGTNKWVLGASANGKPWGKPNTYAYWTGSFDGKEFK ADQTEAQWLDYGFDWYGGVTFEDSKSTDPLEKRYALAWMNNWDYANNTPTMKNGFNGT DSVIRELRLKEQDGTYSLVSQPIEALEQLTVSTDEIEDQDVNGSKTLSITGDTYQLDT DLSWSELKNAGVRLRESEDQKRHIDVGIFAEGGYAYVNRAATNQPDKSNTYVESKAPY DVNKRKVHLKILVDKTTIEVFVGDGKTVFSNEVFPKPEDKGITLYSDGGTASFKNITV KHFDSIHE*" /label="levB CDS" gene 3161830..3163380 /gene="levB" /locus_tag="BSU_34460" /old_locus_tag="BSU34460" /label="levB gene" promotor_-35 3163424..3163430 /Source="Nicolas_upshift_promotors" /id="U2707" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=926 /SigmaFactorBS="caggggcggcgcaggctgcccctgtttttttattaggagcGG TATTCtctgttacatattGGGCATTGTAAGgaatataaggctggtttcaaaggaggaa g" /listShort="yveA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3163444..3163455 /Source="Nicolas_upshift_promotors" /id="U2707" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=926 /SigmaFactorBS="caggggcggcgcaggctgcccctgtttttttattaggagcGG TATTCtctgttacatattGGGCATTGTAAGgaatataaggctggtttcaaaggaggaa g" /listShort="yveA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3163444 /Source="Nicolas_upshifts" /id="U2707" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=926 /SigmaFactorBS="caggggcggcgcaggctgcccctgtttttttattaggagcGG TATTCtctgttacatattGGGCATTGTAAGgaatataaggctggtttcaaaggaggaa g" /listShort="yveA" /GFF_Attribute="listLong" /label="upshifts" CDS 3163488..3165050 /gene="aspP" /locus_tag="BSU_34470" /old_locus_tag="BSU34470" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12730183, 15528654, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12730183, 15528654, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="L-aspartate/L-glutamate / proton permease" /protein_id="NP_391327.1" /db_xref="EnsemblGenomes-Gn:BSU34470" /db_xref="EnsemblGenomes-Tr:CAB15452" /db_xref="GOA:O07002" /db_xref="InterPro:IPR002293" /db_xref="SubtiList:BG12429" /db_xref="UniProtKB/Swiss-Prot:O07002" /translation="MSKQGNFQKSMSLFDLILIGMGAIFGSAWLFAVSNVASKAGPSG AFSWILGGAIILLIGLVYAELGAALPRTGGIIRYPVYSHGHLVGYLISFVTIVAYTSL ISIEVTAVRQYVAYWFPGLTIKGSDSPTISGWILQFALLCLFFLLNYWSVKTFAKANF IISIFKYIVPITIIIVLIFHFQPENLSVQGFAPFGFTGIQAAISTGGVMFAYLGLHPI VSVAGEVQNPKRNIPIALIICIIVSTIIYTVLQVTFIGAIPTETLKHGWPAIGREFSL PFKDIAVMLGLGWLATLVILDAILSPGGNGNIFMNTTSRLVYAWARNGTLFGIFSKVN KDTGTPRASLWLSFALSIFWTLPFPSWNALVNVCSVALILSYAIAPISSAALRVNAKD LNRPFYLKGMSIIGPLSFIFTAFIVYWSGWKTVSWLLGSQLVMFLIYLCFSKYTPKED VSLAQQLKSAWWLIGFYIMMLIFSYIGSFGHGLGIISNPVDLILVAIGSLAIYYWAKY TGLPKAAIDYDK*" /label="aspP CDS" gene 3163488..3165050 /gene="aspP" /locus_tag="BSU_34470" /old_locus_tag="BSU34470" /label="aspP gene" downshifts 3165028 /Source="Nicolas_upshifts" /id="D1784" /incds=0 /nref=12 /ntot=29 /MaxReadThrough="1.71122" /MaxDrop="3.47798" /score="-0.444529447" /energy="-11.7" /TU="NA" /idTUdmin="U2707" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 3165040..3165729 /gene="yvdT" /locus_tag="BSU_34480" /old_locus_tag="BSU34480" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (TetR/AcrR family)" /protein_id="NP_391328.2" /db_xref="EnsemblGenomes-Gn:BSU34480" /db_xref="EnsemblGenomes-Tr:CAB15453" /db_xref="GOA:O07001" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="PDB:2F07" /db_xref="SubtiList:BG12428" /db_xref="UniProtKB/Swiss-Prot:O07001" /translation="MINKEARGFLASLFFTNKHTRDKMNESQSLLEVFLMPKQTSGKY EKILQAAIEVISEKGLDKASISDIVKKAGTAQGTFYLYFSSKNALIPAIAENLLTHTL DQIKGRLHGDEDFWTVLDILIDETFLITERHKDIIVLCYSGLAIDHSMEKWETIYQPY YSWLEKIINKAIANHEVTEGINSKWTARTIINLVENTAERFYIGFEQDENVEVYKKEI FTFLKRSLGTA*" /label="yvdT CDS" gene 3165040..3165729 /gene="yvdT" /locus_tag="BSU_34480" /old_locus_tag="BSU34480" /label="yvdT gene" promotor_-35 3165079..3165086 /Source="Nicolas_upshift_promotors" /id="U2708" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.573426573426573" /psig="0.999000999001" /xcortree=2082 /SigmaFactorBS="aaagaagcaagaggttttcttgcttctttaTTCTTTACaaac aaacatacaCGCGATAAAATGAATGAGAGtcagtcattactggaggtgttcctcatgc c" /listShort="yvdT, yvdS, yvdR, S1315" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3165100..3165119 /Source="Nicolas_upshift_promotors" /id="U2708" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.573426573426573" /psig="0.999000999001" /xcortree=2082 /SigmaFactorBS="aaagaagcaagaggttttcttgcttctttaTTCTTTACaaac aaacatacaCGCGATAAAATGAATGAGAGtcagtcattactggaggtgttcctcatgc c" /listShort="yvdT, yvdS, yvdR, S1315" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3165109 /Source="Nicolas_upshifts" /id="U2708" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.573426573426573" /psig="0.999000999001" /xcortree=2082 /SigmaFactorBS="aaagaagcaagaggttttcttgcttctttaTTCTTTACaaac aaacatacaCGCGATAAAATGAATGAGAGtcagtcattactggaggtgttcctcatgc c" /listShort="yvdT, yvdS, yvdR, S1315" /GFF_Attribute="listLong" /label="upshifts" downshifts 3165710 /Source="Nicolas_upshifts" /id="D1785" /incds=0 /nref=189 /ntot=242 /MaxReadThrough="4.85194" /MaxDrop="4.84113" /score="-0.444529447" /energy="-11.7" /TU="U2708" /idTUdmin="U2707" /TUdmin=682 /isTUend="FALSE" /label="downshifts" downshifts complement(3165808) /Source="Nicolas_upshifts" /id="D1786" /incds=0 /nref=1 /ntot=8 /MaxReadThrough="0.8852" /MaxDrop="3.45447" /score="0.398849185" /energy="-11.7" /TU="NA" /idTUdmin="U2709" /TUdmin=704 /isTUend="FALSE" /label="downshifts" CDS 3165811..3166146 /gene="psmA" /locus_tag="BSU_34490" /old_locus_tag="BSU34490" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 22978536; Product type t : transporter" /codon_start=1 /transl_table=11 /product="sodium / proton antiporter subunit A" /protein_id="NP_391329.1" /db_xref="EnsemblGenomes-Gn:BSU34490" /db_xref="EnsemblGenomes-Tr:CAB15454" /db_xref="GOA:O32262" /db_xref="InterPro:IPR000390" /db_xref="SubtiList:BG12427" /db_xref="UniProtKB/Swiss-Prot:O32262" /translation="MNWVLVFIAGLLEVVWASSLKHADSLLDWIIIFILIAVSFILLI RSYQKIPMAAAYTVFVGIGTVGTYLTGIVLGESFSAAQMFFLALLLAGILGMKLFTKE SKSQPGGEK*" /label="psmA CDS" gene 3165811..3166146 /gene="psmA" /locus_tag="BSU_34490" /old_locus_tag="BSU34490" /label="psmA gene" CDS 3166146..3166466 /gene="psmB" /locus_tag="BSU_34500" /old_locus_tag="BSU34500" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11160890, 22978536; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sodium-proton two component antiporter subunit" /protein_id="NP_391330.1" /db_xref="EnsemblGenomes-Gn:BSU34500" /db_xref="EnsemblGenomes-Tr:CAB15455" /db_xref="GOA:O06999" /db_xref="InterPro:IPR000390" /db_xref="SubtiList:BG12426" /db_xref="UniProtKB/Swiss-Prot:O06999" /translation="MAWFLLVIAGIEEIIAAIAMKYIDGTRKKWPIIVMTVGFGLSFY CLSQAMIVLPAGVAYAVWTGIGSIGVSAVGLIWFKERFQLSQVISLCLILAGVIGLRL TSSS*" /label="psmB CDS" gene 3166146..3166466 /gene="psmB" /locus_tag="BSU_34500" /old_locus_tag="BSU34500" /label="psmB gene" S_feature 3166467..3166657 /Source="Nicolas_S_feature" /locus_tag="new_3542144_3542334" /HighExp="Sw, BC, BI, Lbstat, M0t90, Lbtran, M40t90, H2O2, S8, Paraq" /AntisenseName="yvdQ" /AntisenseCor="3.5547360410813897E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1315" CDS complement(3166502..3167014) /gene="yvdQ" /locus_tag="BSU_34510" /old_locus_tag="BSU34510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391331.1" /db_xref="EnsemblGenomes-Gn:BSU34510" /db_xref="EnsemblGenomes-Tr:CAB15456" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR021617" /db_xref="SubtiList:BG12425" /db_xref="UniProtKB/Swiss-Prot:O06998" /translation="MGILSGNPQDEPMHYGEVFGLWSYVMAGNKMVGNYQMLLNHVGD DDLKKLLRESIEKCQDEIKQVSTILKENGVALPPASPEPPTADLNDIPPGARFLDPDV AASAAAENAAGLVTCSKMMGQSIREDIAMMFGQFHMSKAATGAKYLRLLKNKGWLIPP PLHLQKHHEA*" /label="yvdQ CDS" gene complement(3166502..3167014) /gene="yvdQ" /locus_tag="BSU_34510" /old_locus_tag="BSU34510" /label="yvdQ gene" downshifts 3166634 /Source="Nicolas_upshifts" /id="D1787" /incds=1 /nref=6 /ntot=39 /MaxReadThrough="1.61612" /MaxDrop="4.65362" /score="0.608596632" /energy="-14.2" /TU="NA" /idTUdmin="U2708" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3167050..3167061) /Source="Nicolas_upshift_promotors" /id="U2709" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=891 /SigmaFactorBS="tgttttgtttcatttcataaatcttttccgctgaAACATAAa tgttcctccgcttGGGCACGTTATGaaatgtgcaatattgaatatgggaggagaatga g" /listShort="yvdQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3167056) /Source="Nicolas_upshifts" /id="U2709" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=891 /SigmaFactorBS="tgttttgtttcatttcataaatcttttccgctgaAACATAAa tgttcctccgcttGGGCACGTTATGaaatgtgcaatattgaatatgggaggagaatga g" /listShort="yvdQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3167076..3167082) /Source="Nicolas_upshift_promotors" /id="U2709" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=891 /SigmaFactorBS="tgttttgtttcatttcataaatcttttccgctgaAACATAAa tgttcctccgcttGGGCACGTTATGaaatgtgcaatattgaatatgggaggagaatga g" /listShort="yvdQ" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3167129..3167265) /Source="Nicolas_S_feature" /locus_tag="new_3542806_3542942_c" /HighExp="BT, S7, S8, S6, B36, G/S, S5, Pyr, G135, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1316" downshifts complement(3167172) /Source="Nicolas_upshifts" /id="D1788" /incds=0 /nref=1 /ntot=38 /MaxReadThrough="3.38169" /MaxDrop="2.9968" /score="15.2862513" /energy="-10.3" /TU="U2710" /idTUdmin="U2709" /TUdmin="-660" /isTUend="FALSE" /label="downshifts" CDS complement(3167266..3168609) /gene="cotNP" /locus_tag="BSU_34520" /old_locus_tag="BSU34520" /EC_number="1.-.-.-" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12562816" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562816; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore coat protein; putative oxidoreductase" /protein_id="NP_391332.1" /db_xref="EnsemblGenomes-Gn:BSU34520" /db_xref="EnsemblGenomes-Tr:CAB15457" /db_xref="GOA:O06997" /db_xref="InterPro:IPR006094" /db_xref="InterPro:IPR012951" /db_xref="InterPro:IPR016166" /db_xref="InterPro:IPR016167" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG12424" /db_xref="UniProtKB/Swiss-Prot:O06997" /translation="MGSTQLTGRVIFKGDPGYTEAIKNWNPYVDVYPLVFVFAQNSYD VSNAIKWARENKVPLRVRSGRHALDKNLSVVSGGIVIDVSDMNKVFLDEENAIATVQT GIPVGPLVKGLARDGFMAPFGDSPTVGIGGITMGGGFGVLSRSIGLISDNLLALKTVD AKGRIIHADQSHNEDLLWASRGGGGGNFGYNTQYTFKVHRAPKTATVFNIIWPWEQLE TVFKAWQKWAPFVDERLGCYLEIYSKINGLCHAEGIFLGSKTELIRLLKPLLHAGTPT EADIKTLYYPDAIDFLDPDEPIPGRNDQSVKFSSAWGHDFWSDEPISIMRKFLEDATG TEANFFFINWGGAISRVPKDETAFFWRHPLFYTEWTASWKNKSQEDSNLASVERVRQL MQPYVAGSYVNVPDQNIENFGKEYYGANFARLREIKAKYDPENVFRFPQSIPPSR*" /label="cotNP CDS" gene complement(3167266..3168609) /gene="cotNP" /locus_tag="BSU_34520" /old_locus_tag="BSU34520" /label="cotNP gene" promotor_-10 complement(3168638..3168657) /Source="Nicolas_upshift_promotors" /id="U2710" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1342 /SigmaFactorBS="attatatttatagttcgtagatcatttGTCTATGCGAttatc cagctccTGCATATTTTAGTATCTGAAtcgaatttctttgggagtgaaataatatatg g" /listShort="yvdP, S1316, yvdQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3168646) /Source="Nicolas_upshifts" /id="U2710" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1342 /SigmaFactorBS="attatatttatagttcgtagatcatttGTCTATGCGAttatc cagctccTGCATATTTTAGTATCTGAAtcgaatttctttgggagtgaaataatatatg g" /listShort="yvdP, S1316, yvdQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3168670..3168679) /Source="Nicolas_upshift_promotors" /id="U2710" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1342 /SigmaFactorBS="attatatttatagttcgtagatcatttGTCTATGCGAttatc cagctccTGCATATTTTAGTATCTGAAtcgaatttctttgggagtgaaataatatatg g" /listShort="yvdP, S1316, yvdQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3168671..3168676 /Source="Nicolas_upshift_promotors" /id="U2711" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1039 /SigmaFactorBS="cgattcagatactaaaatatgcaggagctggataatCGCATA gacaaatgatctacgAACTATAAATATAATACGCtaaggcctttttcgtcggtgaggt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3168692..3168710 /Source="Nicolas_upshift_promotors" /id="U2711" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1039 /SigmaFactorBS="cgattcagatactaaaatatgcaggagctggataatCGCATA gacaaatgatctacgAACTATAAATATAATACGCtaaggcctttttcgtcggtgaggt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3168695 /Source="Nicolas_upshifts" /id="U2711" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1039 /SigmaFactorBS="cgattcagatactaaaatatgcaggagctggataatCGCATA gacaaatgatctacgAACTATAAATATAATACGCtaaggcctttttcgtcggtgaggt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3168904..3168913 /Source="Nicolas_upshift_promotors" /id="U2712" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1360 /SigmaFactorBS="aagaaaagagagatgaagaagtgtttagtaccagaggtatac ATCCATACAAcagactctagatcATCATATACTGAATGTATGTagaaaggagacatca g" /listShort="cotR, S1317" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3168922 /Source="Nicolas_upshifts" /id="U2712" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1360 /SigmaFactorBS="aagaaaagagagatgaagaagtgtttagtaccagaggtatac ATCCATACAAcagactctagatcATCATATACTGAATGTATGTagaaaggagacatca g" /listShort="cotR, S1317" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3168927..3168946 /Source="Nicolas_upshift_promotors" /id="U2712" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1360 /SigmaFactorBS="aagaaaagagagatgaagaagtgtttagtaccagaggtatac ATCCATACAAcagactctagatcATCATATACTGAATGTATGTagaaaggagacatca g" /listShort="cotR, S1317" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3168965..3169927 /gene="cotR" /locus_tag="BSU_34530" /old_locus_tag="BSU34530" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11737650, 20378985" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11737650, 20378985; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore coat lipolytic enzyme" /protein_id="NP_391333.1" /db_xref="EnsemblGenomes-Gn:BSU34530" /db_xref="EnsemblGenomes-Tr:CAB15458" /db_xref="GOA:O06996" /db_xref="InterPro:IPR002641" /db_xref="InterPro:IPR016035" /db_xref="SubtiList:BG12423" /db_xref="UniProtKB/Swiss-Prot:O06996" /translation="MAKYRIMTFDGGGTLGALSLQLLNRLARQNPKLISRTHVFSGNS IGSFTALALASGRSPRETLQYFEDEILPAFSISRPGGPVFNQQLPYSGFIKAVRNFFP ADLQLIDLRKRIVVPSFKLYSQKLDRWTPVLFHNFPGSPYLNEKVSDVILRSSGAPAT QRAYQNYVDGYVVATNPSTASIAFAVGKANVPLDQIAVLSIGTGEAPTRLRRDTRGWG MVSADNIRPENLKNLPPNWGVLLDRSPNEPLLPFLQMIAGGNGYYESMVSANLLGDRF FRLDPRIPNFSKTDPAVVPAVIEIANKTNLQPANQFIEKNWGSK*" /label="cotR CDS" gene 3168965..3169927 /gene="cotR" /locus_tag="BSU_34530" /old_locus_tag="BSU34530" /label="cotR gene" S_feature 3169928..3170181 /Source="Nicolas_S_feature" /locus_tag="new_3545605_3545858" /HighExp="BT, S8, S7, B36, S6, Pyr, G/S, S3, C30, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1317" downshifts complement(3170208) /Source="Nicolas_upshifts" /id="D1789" /incds=0 /nref=190 /ntot=241 /MaxReadThrough="3.19421" /MaxDrop="5.60739" /score="16.7489574" /energy="-13.2" /TU="U2713" /idTUdmin="U2713" /TUdmin="-308" /isTUend="FALSE" /label="downshifts" tRNA complement(3170212..3170287) /gene="trnQ-Arg" /locus_tag="BSU_tRNA_81" /product="tRNA-Arg" /inference="profile:tRNAscan:1.23" /note="arginine transfer RNA (CCG); Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 27749819; Product type n : RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnQ-Arg tRNA" gene complement(3170212..3170287) /gene="trnQ-Arg" /locus_tag="BSU_tRNA_81" /label="trnQ-Arg gene" promotor_-10 complement(3170314..3170333) /Source="Nicolas_upshift_promotors" /id="U2713" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.508491508491508" /psig=1 /xcortree=2857 /SigmaFactorBS="aagatgctttgtctatttaaaaaacggcctctcgaaatagag gGTTGttatttgaaaggaatTATCGTATAATTAGTTGTGCtgacgttctcataacgca g" /listShort="trnQ-Arg" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3170335) /Source="Nicolas_upshifts" /id="U2713" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.508491508491508" /psig=1 /xcortree=2857 /SigmaFactorBS="aagatgctttgtctatttaaaaaacggcctctcgaaatagag gGTTGttatttgaaaggaatTATCGTATAATTAGTTGTGCtgacgttctcataacgca g" /listShort="trnQ-Arg" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3170349..3170352) /Source="Nicolas_upshift_promotors" /id="U2713" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.508491508491508" /psig=1 /xcortree=2857 /SigmaFactorBS="aagatgctttgtctatttaaaaaacggcctctcgaaatagag gGTTGttatttgaaaggaatTATCGTATAATTAGTTGTGCtgacgttctcataacgca g" /listShort="trnQ-Arg" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3170418..3170424 /Source="Nicolas_upshift_promotors" /id="U2714" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=726 /SigmaFactorBS="ttttaaatagacaaagcatcttaattggcaatctgacatacg atGGTTTGAacccctgtatttttGGGGAAAATGGGAAAAAGAGacgactttgcatatc a" /listShort="S1318, clpP, S1319" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3170434..3170509 /Source="Nicolas_S_feature" /locus_tag="new_3546111_3546186" /HighExp="Salt, S3, S4, Etha, S5, LoTm, Gly, M9-stat, BT, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1318" upshifts 3170434 /Source="Nicolas_upshifts" /id="U2714" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=726 /SigmaFactorBS="ttttaaatagacaaagcatcttaattggcaatctgacatacg atGGTTTGAacccctgtatttttGGGGAAAATGGGAAAAAGAGacgactttgcatatc a" /listShort="S1318, clpP, S1319" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3170439..3170458 /Source="Nicolas_upshift_promotors" /id="U2714" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=726 /SigmaFactorBS="ttttaaatagacaaagcatcttaattggcaatctgacatacg atGGTTTGAacccctgtatttttGGGGAAAATGGGAAAAAGAGacgactttgcatatc a" /listShort="S1318, clpP, S1319" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 3170486..3170493 /Source="Nicolas_upshift_promotors" /id="U2715" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.975024975024975" /psig=1 /xcortree=1938 /SigmaFactorBS="aaaaagagacgactttgcatatcaggccagcttttTGTTTGA CctttattgaccaaAAATGTATCATGTAACTACAtacttacctaaaaggtgaaggagg a" /listShort="clpP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3170507..3170526 /Source="Nicolas_upshift_promotors" /id="U2715" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.975024975024975" /psig=1 /xcortree=1938 /SigmaFactorBS="aaaaagagacgactttgcatatcaggccagcttttTGTTTGA CctttattgaccaaAAATGTATCATGTAACTACAtacttacctaaaaggtgaaggagg a" /listShort="clpP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3170511 /Source="Nicolas_upshifts" /id="U2715" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.975024975024975" /psig=1 /xcortree=1938 /SigmaFactorBS="aaaaagagacgactttgcatatcaggccagcttttTGTTTGA CctttattgaccaaAAATGTATCATGTAACTACAtacttacctaaaaggtgaaggagg a" /listShort="clpP" /GFF_Attribute="listLong" /label="upshifts" CDS 3170557..3171150 /gene="clpP" /locus_tag="BSU_34540" /old_locus_tag="BSU34540" /EC_number="3.4.21.92" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11722737, 11807061, 15317791, 16163393, 21546913, 21969594, 22226636, 27749819" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11722737, 11807061, 15317791, 16163393, 21546913, 21969594, 22226636, 27749819; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent Clp protease proteolytic subunit; Maxwell's demon" /protein_id="NP_391334.1" /db_xref="EnsemblGenomes-Gn:BSU34540" /db_xref="EnsemblGenomes-Tr:CAB15459" /db_xref="GOA:P80244" /db_xref="InterPro:IPR001907" /db_xref="InterPro:IPR018215" /db_xref="InterPro:IPR023562" /db_xref="InterPro:IPR029045" /db_xref="InterPro:IPR033135" /db_xref="PDB:3KTG" /db_xref="PDB:3KTH" /db_xref="PDB:3KTI" /db_xref="PDB:3KTJ" /db_xref="PDB:3KTK" /db_xref="PDB:3TT6" /db_xref="PDB:3TT7" /db_xref="SubtiList:BG19016" /db_xref="UniProtKB/Swiss-Prot:P80244" /translation="MNLIPTVIEQTNRGERAYDIYSRLLKDRIIMLGSAIDDNVANSI VSQLLFLAAEDPEKEISLYINSPGGSITAGMAIYDTMQFIKPKVSTICIGMAASMGAF LLAAGEKGKRYALPNSEVMIHQPLGGAQGQATEIEIAAKRILLLRDKLNKVLAERTGQ PLEVIERDTDRDNFKSAEEALEYGLIDKILTHTEDKK*" /label="clpP CDS" gene 3170557..3171150 /gene="clpP" /locus_tag="BSU_34540" /old_locus_tag="BSU34540" /label="clpP gene" downshifts 3171139 /Source="Nicolas_upshifts" /id="D1790" /incds=0 /nref=292 /ntot=300 /MaxReadThrough="4.45406" /MaxDrop="8.24306" /score="30.2626808" /energy="-14.6" /TU="U2714" /idTUdmin="U2715" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" S_feature 3171184..3171582 /Source="Nicolas_S_feature" /locus_tag="new_3546861_3547259" /HighExp="Etha, dia15, Heat, LoTm, M9-stat, Gly, dia5, Diami, S8, H2O2" /AntisenseName="pgcM" /AntisenseCor="0.13310786898312499" /AntisenseRegPval="-1.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1319" CDS complement(3171196..3171876) /gene="mdxM" /locus_tag="BSU_34550" /old_locus_tag="BSU34550" /EC_number="2.7.1.41" /EC_number="5.4.2.6" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:4275311, 11081794, 15996095" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4275311, 11081794, 15996095; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional beta-phosphoglucomutase / glucose-1-phosphate phosphodismutase" /protein_id="NP_391335.1" /db_xref="EnsemblGenomes-Gn:BSU34550" /db_xref="EnsemblGenomes-Tr:CAB15460" /db_xref="GOA:O06995" /db_xref="InterPro:IPR006439" /db_xref="InterPro:IPR010972" /db_xref="InterPro:IPR010976" /db_xref="InterPro:IPR023198" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="PDB:3NAS" /db_xref="SubtiList:BG12422" /db_xref="UniProtKB/Swiss-Prot:O06995" /translation="MKAVIFDLDGVITDTAEYHFLAWKHIAEQIDIPFDRDMNERLKG ISREESLESILIFGGAETKYTNAEKQELMHRKNRDYQMLISKLTPEDLLPGIGRLLCQ LKNENIKIGLASSSRNAPKILRRLAIIDDFHAIVDPTTLAKGKPDPDIFLTAAAMLDV SPADCAAIEDAEAGISAIKSAGMFAVGVGQGQPMLGADLVVRQTSDLTLELLHEEWEQ YRIRESIP*" /label="mdxM CDS" gene complement(3171196..3171876) /gene="mdxM" /locus_tag="BSU_34550" /old_locus_tag="BSU34550" /label="mdxM gene" downshifts complement(3171220) /Source="Nicolas_upshifts" /id="D1791" /incds=0 /nref=2 /ntot=36 /MaxReadThrough="3.4944" /MaxDrop="3.50516" /score="-9.43329271" /energy="-14.6" /TU="U2718" /idTUdmin="U2718" /TUdmin="-506" /isTUend="FALSE" /label="downshifts" CDS complement(3171873..3173558) /gene="mdxL" /locus_tag="BSU_34560" /old_locus_tag="BSU34560" /EC_number="3.2.1.10" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9573215, 10229946, 1670768" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9573215, 10229946, 1670768; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oligo-1,4-1,6-alpha-glucosidase (sucrase-maltase-isomaltase)" /protein_id="NP_391336.1" /db_xref="EnsemblGenomes-Gn:BSU34560" /db_xref="EnsemblGenomes-Tr:CAB15461" /db_xref="GOA:O06994" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR032091" /db_xref="PDB:4M56" /db_xref="PDB:4M8U" /db_xref="PDB:4MAZ" /db_xref="PDB:4MB1" /db_xref="SubtiList:BG12421" /db_xref="UniProtKB/Swiss-Prot:O06994" /translation="MSEWWKEAVVYQIYPRSFYDANGDGFGDLQGVIQKLDYIKNLGA DVIWLSPVFDSPQDDNGYDISDYKNMYEKFGTNEDMFQLIDEVHKRGMKIVMDLVVNH TSDEHAWFAESRKSKDNPYRDYYLWKDPKPDGSEPNNWGSIFSGSAWTYDEGTGQYYL HYFSKKQPDLNWENEAVRREVYDVMRFWMDRGVDGWRMDVIGSISKYTDFPDYETDHS RSYIVGRYHSNGPRLHEFIQEMNREVLSHYDCMTVGEANGSDIEEAKKYTDASRQELN MIFTFEHMDIDKEQNSPNGKWQIKPFDLIALKKTMTRWQTGLMNVGWNTLYFENHDQP RVISRWGNDRKLRKECAKAFATVLHGMKGTPFIYQGEEIGMVNSDMPLEMYDDLEIKN AYRELVVENKTMSEKEFVKAVMIKGRDHARTPMQWDAGKHAGFTAGDPWIPVNSRYQD INVKESLEDQDSIFFYYQKLIQLRKQYKIMIYGDYQLLQENDPQVFSYLREYRGEKLL VVVNLSEEKALFEAPPELIHERWKVLISNYPQERADLKSISLKPYEAVMGISI*" /label="mdxL CDS" gene complement(3171873..3173558) /gene="mdxL" /locus_tag="BSU_34560" /old_locus_tag="BSU34560" /label="mdxL gene" CDS complement(3173551..3175824) /gene="mdxK" /locus_tag="BSU_34570" /old_locus_tag="BSU34570" /EC_number="2.4.1.8" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16707683, 28527120" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16707683, 28527120; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="maltose phosphorylase" /protein_id="NP_391337.1" /db_xref="EnsemblGenomes-Gn:BSU34570" /db_xref="EnsemblGenomes-Tr:CAB15462" /db_xref="GOA:O06993" /db_xref="InterPro:IPR005194" /db_xref="InterPro:IPR005195" /db_xref="InterPro:IPR005196" /db_xref="InterPro:IPR008928" /db_xref="InterPro:IPR011013" /db_xref="InterPro:IPR017045" /db_xref="SubtiList:BG12420" /db_xref="UniProtKB/Swiss-Prot:O06993" /translation="MINQRLFEIDEWKIKTNTFNKEHTRLLESLTSLANGYMGVRGNF EEGYSGDSHQGTYIAGVWFPDKTRVGWWKNGYPEYFGKVINAMNFMGIGLYVDGEKID LHQNPIELFEVELNMKEGILRRSAVVRIQDKTVRIRSERFLSLAVKELCAIHYEAECL TGDAVITLVPYLDGNVANEDSNYQEQFWQEEAKGADSHSGHLAAKTIENPFGTPRFTV LAAMANETEGFVHESFKTTEMYVENRYSYQTKASLKKFVIVTTSRDFREEELLSKAKE LLADVVENGYEDAKRRHTDRWKERWAKADIEIKGDEELQQGIRYNIFQLFSTYYGGDA RLNIGPKGFTGEKYGGAAYWDTEAYAVPMYLATAEPEVTKNLLLYRYHQLEAAKRNAA KLGMKGALYPMVTFTGDECHNEWEITFEEIHRNGAICYAIYNYINYTGDRNYMEEYGI DVLVAVSRFWADRVHFSKRKNKYMIHGVTGPNEYENNVNNNWYTNVIAAWTLEYTLQS LESISAEKRRHLDVQEVELEVWREIIQHMYYPFSEELQIFVQHDTFLDKDLQTVDELD PAERPLYQNWSWDKILRSNFIKQADVLQGIYLFNDRFTMEEKRRNFEFYEPMTVHESS LSPSVHAILAAELKLEKKALELYKRTARLDLDNYNHDTEEGLHITSMTGSWLAIVHGF AGMRTANETLSFAPFLPKEWDEYSFNINYRNRLINVTVDEKRVIFELVKGEPLHMNVY EEPVVLQGRCERRTPNE*" /label="mdxK CDS" gene complement(3173551..3175824) /gene="mdxK" /locus_tag="BSU_34570" /old_locus_tag="BSU34570" /label="mdxK gene" CDS complement(3175802..3176686) /gene="mdxJ" /locus_tag="BSU_34580" /old_locus_tag="BSU34580" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16707683, 16850406, 20436965; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative component of maltodextrin transporter" /protein_id="NP_391338.1" /db_xref="EnsemblGenomes-Gn:BSU34580" /db_xref="EnsemblGenomes-Tr:CAB15463" /db_xref="GOA:O06992" /db_xref="InterPro:IPR009574" /db_xref="SubtiList:BG12419" /db_xref="UniProtKB/Swiss-Prot:O06992" /translation="MKNLENKSFIIRCLKAAASPSGVCRYGNTFSWLQLSFLFLFLTA CLMAPLAVSFVKMDRFSVSSFMPSAIQGVNDQFADQLQGFQIRNGKLTGGKSSERIED GQNVMAVDMKHEYETSGENGRLKVTGFENAIIFQPDQLVITDQNETGFSVGYAKMDVK LEKPNVHDVEVLIDTLWLAQYKPMIMMLAYTVVSMIQLLLTFVLAGGLWITKISNMVS IASFKEAASIAICASALPAFAAAAIGMVHFDLITVLMIHSCGVTLMISFAFRYLTKTR RDNGNLHSGGNDDKSAVI*" /label="mdxJ CDS" gene complement(3175802..3176686) /gene="mdxJ" /locus_tag="BSU_34580" /old_locus_tag="BSU34580" /label="mdxJ gene" CDS complement(3176692..3177528) /gene="mdxG" /locus_tag="BSU_34590" /old_locus_tag="BSU34590" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16707683, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16707683, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="maltodextrin ABC transporter (permease)" /protein_id="NP_391339.1" /db_xref="EnsemblGenomes-Gn:BSU34590" /db_xref="EnsemblGenomes-Tr:CAB15464" /db_xref="GOA:O06991" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12418" /db_xref="UniProtKB/Swiss-Prot:O06991" /translation="MNASTARMLNKICTYLFLTLLSIVIIYPLLITASSAFRVGNSAA FQLDFSGSWTLDHFKRLFDETLYLNWYSNTLVIALSVMVLQVTIVTLAGYSYSRYRFA GRKKSLIFFLIIQMVPTMAALTAFYVLAMLIGALDQYWFLTAIYIGGGIPMNTWLMKG YFDTVPREIDEAARIDGAGHLRIFASIVLPLVKPMLAVQALWAFMAPFGDYLLTKFLL RSPERLTIAVGLQSFISNPQQQKVALFAAGAILAALPICVLFFFLQKNFVSGLTAGGT KG*" /label="mdxG CDS" gene complement(3176692..3177528) /gene="mdxG" /locus_tag="BSU_34590" /old_locus_tag="BSU34590" /label="mdxG gene" CDS complement(3177529..3178836) /gene="mdxF" /locus_tag="BSU_34600" /old_locus_tag="BSU34600" /experiment="publication(s) with functional evidences, PMID:15849754, 16707683, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16707683, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="maltodextrin ABC transport system (permease)" /protein_id="NP_391340.1" /db_xref="EnsemblGenomes-Gn:BSU34600" /db_xref="EnsemblGenomes-Tr:CAB15465" /db_xref="GOA:O06990" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035277" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12417" /db_xref="UniProtKB/Swiss-Prot:O06990" /translation="MNKHHTLTKQKRKAGLLSIIPGLGQIANQQLSKGLLFLAITGLF AFELCVFGIQALTGLMTLGSVPGEDHSLFMLIEGTLQLIVTMIFLMFYIFNIHDSRKT AAMKAAGLEVNTTAKDMICHAGDKGFPYLFTLPAYIMMVFVIIFPVLVTLFVALTNYD FYHIPPNRLIDWVGFKNFLNIFFLGSYRETFVNVLGWTVIWTICATTLQIILGIVTAL FVNQDFIKGKRIFRMIFLFPWAVPAFITIMSFSNMFNDSIGAVNAQVIPLFNHLPFVE LPAIAWKTDPFWTKTALIMIQTWLGFPYIYVMVTGVLQAIPGELYEAAKIDGATFIQR FRHITFPMILFATAPVMITQYTFNFNNFSIIYLFNEGGPGSAGAGAGSTDILISWIYK LTTGTSPQYSVAAAVTLLISFIVIGISLIAFKKSNAFGNEEVM*" /label="mdxF CDS" gene complement(3177529..3178836) /gene="mdxF" /locus_tag="BSU_34600" /old_locus_tag="BSU34600" /label="mdxF gene" promotor_-35 3177894..3177903 /Source="Nicolas_upshift_promotors" /id="U2716" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1371 /SigmaFactorBS="atctttgccgcttcatacaattcacctggaatcgCCTGAAGC ACtcccgttaccatGACATATATATATGGAAAGCcgagccacgtttgaatcataatga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3177916..3177935 /Source="Nicolas_upshift_promotors" /id="U2716" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1371 /SigmaFactorBS="atctttgccgcttcatacaattcacctggaatcgCCTGAAGC ACtcccgttaccatGACATATATATATGGAAAGCcgagccacgtttgaatcataatga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3177920 /Source="Nicolas_upshifts" /id="U2716" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1371 /SigmaFactorBS="atctttgccgcttcatacaattcacctggaatcgCCTGAAGC ACtcccgttaccatGACATATATATATGGAAAGCcgagccacgtttgaatcataatga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3178876..3180129) /gene="mdxE" /locus_tag="BSU_34610" /old_locus_tag="BSU34610" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16707683" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16707683; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="maltose/maltodextrin-binding lipoprotein" /protein_id="NP_391341.1" /db_xref="EnsemblGenomes-Gn:BSU34610" /db_xref="EnsemblGenomes-Tr:CAB15466" /db_xref="GOA:O06989" /db_xref="InterPro:IPR006060" /db_xref="SubtiList:BG12416" /db_xref="UniProtKB/Swiss-Prot:O06989" /translation="MVLLKKGFAILAASFLAIGLAACSSSKNPASSDGKKVLTVSVEE TYKEYIESIKTKFEKENDVTVKIVEKQMFEQLEALPLDGPAGNAPDVMLAAYDRIGGL GQQGHLLDIKPSNTKSFGDKEMQQVTVDGKVYGMPLVIETLILYYNKDLLKTAPKTFK DLEKLTEDPRFAFASEKGKSTGFLAKWTDFYMSYGLLAGYGGYVFGKNGTDSGDIGLN NKGAVEAVKYAEKWFETYWPKGMQDNSSADDFIQQMFLEGKAAAIIGGPWSAANYKEA KLNYGAAPIPTLPNGEEYAPFAGGKGWVASKYTKEPELAEKWLEYAANDANAYAFYED TNEVPANTAARKKADEQKNELTSAVIKQYETATPTPNIPEMAEVWTGAESLIFDAASG KKSTQTSANDAVNVIKENIKEKYVK*" /label="mdxE CDS" gene complement(3178876..3180129) /gene="mdxE" /locus_tag="BSU_34610" /old_locus_tag="BSU34610" /label="mdxE gene" S_feature complement(3180130..3180224) /Source="Nicolas_S_feature" /locus_tag="new_3555807_3555901_c" /HighExp="T1.0H, T0.30H, BC, T1.30H, M40t90, M0t90, BI, B60, S8, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.804" /TUlongSig="NA" /TUlongPSig="NA" /label="S1320" CDS complement(3180225..3181994) /gene="mdxD" /locus_tag="BSU_34620" /old_locus_tag="BSU34620" /EC_number="3.2.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10825545, 15650689, 16707683, 19465663, 27871383, 27871383" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10825545, 15650689, 16707683, 19465663, 27871383, 27871383; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="maltogenic alpha-amylase" /protein_id="NP_391342.1" /db_xref="EnsemblGenomes-Gn:BSU34620" /db_xref="EnsemblGenomes-Tr:CAB15467" /db_xref="GOA:O06988" /db_xref="InterPro:IPR004185" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR013777" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG12415" /db_xref="UniProtKB/Swiss-Prot:O06988" /translation="MMEYAAIHHQPFSTDAYSYDGRTVHIKIRTKKGDADHIRFIWGD PYEYNDGKWSANEQPMRKIAATEMHDYWFAEVVPPFRRLQYAFVVTDDHEDIFFGSSG VCPYNEKTLETIHYYFKFPFVHEADTFQAPEWVKSTVWYQIFPERFANGREDLSPKNA LPWGSKDPDVNDFFGGDLQGIVDKLDYLEDLGVNGIYLTPIFSAPSNHKYDTLDYFSI DPHFGDPELFRTLVSQLHQRGMRIMLDAVFNHIGSASPQWQDVVKNGDQSRYKDWFHI HSFPVTDDNYDRFAFTADMPKLNTANPEVQKYLLDIALYWIREFDIDGWRLDVANEVD HVFWKTFRQAVSTEKPDVYILGEIWHSAEPWLRGDEFHAAMNYPFTEPMIEYFADQTI SASRMAHRVNAHLMNGMKQANEVMFNLLDSHDTKRLLTRCRNDEKKARALLAFMFAQT GSPCIYYGTEIGLNGENDPLCRKCMVWEKEKQNQDMLQFMKRLIALRKQENTLLTEGH LEWNLLDDKNDFISFSRTLDEKILIYFFNQGNVVQHVSLRELNIDRNKKICDAWTEQP LQHHDVIAVQPGEFLILSAAAPV*" /label="mdxD CDS" gene complement(3180225..3181994) /gene="mdxD" /locus_tag="BSU_34620" /old_locus_tag="BSU34620" /label="mdxD gene" promotor_-35 3181915..3181920 /Source="Nicolas_upshift_promotors" /id="U2717" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1040 /SigmaFactorBS="gatctgcatcaccttttttcgtccgaatcTTGATAtgcacag tccgcccaTCATAAGAATAAGCATCTGtgctgaatggctggtgatgaatcgctgcata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3181936..3181954 /Source="Nicolas_upshift_promotors" /id="U2717" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1040 /SigmaFactorBS="gatctgcatcaccttttttcgtccgaatcTTGATAtgcacag tccgcccaTCATAAGAATAAGCATCTGtgctgaatggctggtgatgaatcgctgcata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3181946 /Source="Nicolas_upshifts" /id="U2717" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1040 /SigmaFactorBS="gatctgcatcaccttttttcgtccgaatcTTGATAtgcacag tccgcccaTCATAAGAATAAGCATCTGtgctgaatggctggtgatgaatcgctgcata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3182032..3182051) /Source="Nicolas_upshift_promotors" /id="U2718" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.538461538461538" /psig="0.804195804195804" /xcortree=343 /SigmaFactorBS="cgccttattctgttatcggtaacagggtgaaaagGATTGTTC ccacaatttcatCATGATACTTTCAAACTATGagccggcttcaataaaacggaaatca a" /listShort="mdxD, S1320, mdxE, mdxF, mdxG, yvdJ, malK, malL, pgcM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3182045) /Source="Nicolas_upshifts" /id="U2718" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.538461538461538" /psig="0.804195804195804" /xcortree=343 /SigmaFactorBS="cgccttattctgttatcggtaacagggtgaaaagGATTGTTC ccacaatttcatCATGATACTTTCAAACTATGagccggcttcaataaaacggaaatca a" /listShort="mdxD, S1320, mdxE, mdxF, mdxG, yvdJ, malK, malL, pgcM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3182064..3182071) /Source="Nicolas_upshift_promotors" /id="U2718" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.538461538461538" /psig="0.804195804195804" /xcortree=343 /SigmaFactorBS="cgccttattctgttatcggtaacagggtgaaaagGATTGTTC ccacaatttcatCATGATACTTTCAAACTATGagccggcttcaataaaacggaaatca a" /listShort="mdxD, S1320, mdxE, mdxF, mdxG, yvdJ, malK, malL, pgcM" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3182107..3183057) /gene="mdxR" /locus_tag="BSU_34630" /old_locus_tag="BSU34630" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16707683, 23951303" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16707683, 23951303; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional activator of the maltodextrin operon (LacI family)" /protein_id="NP_391343.1" /db_xref="EnsemblGenomes-Gn:BSU34630" /db_xref="EnsemblGenomes-Tr:CAB15468" /db_xref="GOA:O06987" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG12414" /db_xref="UniProtKB/Swiss-Prot:O06987" /translation="MATLSDVAKKANVSKMTVSRVINHPETVTDELKKLVHSAMKELN YIPNYAARALVQNRTQVVKLLILEEMDTTEPYYMNLLTGISRELDRNHYALQLVTRNS LNIGQCDGIIATGLRKNDFEGVIKAFEKPLVVFGQNEMGYDFIDVNNEKGTFMATRHV MGLGEREVVFFGIDLDEPFERAREQGYIRAMNKSFKKSNMFRIDNSSKKSECLARELL KSMDNQAAFVCASDRIALGVIRAAQSLGKRIPEDVAVTGNDGVFLDRISSPRLTTVRQ PVVEMGEACAKMLLKKMNEDGAAQGSLFFEPELIVRESTL*" /label="mdxR CDS" gene complement(3182107..3183057) /gene="mdxR" /locus_tag="BSU_34630" /old_locus_tag="BSU34630" /label="mdxR gene" promotor_-10 complement(3183072..3183090) /Source="Nicolas_upshift_promotors" /id="U2719" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.98101898101898" /psig="0.98101898101898" /xcortree=516 /SigmaFactorBS="ttctctttggcctgcatcgtatatttagcagtaatAGAGGAC TTtatcactagttTGGATAATAAGCACAGATAaggaggggatgaaaatggcaacattg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3183085) /Source="Nicolas_upshifts" /id="U2719" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.98101898101898" /psig="0.98101898101898" /xcortree=516 /SigmaFactorBS="ttctctttggcctgcatcgtatatttagcagtaatAGAGGAC TTtatcactagttTGGATAATAAGCACAGATAaggaggggatgaaaatggcaacattg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3183102..3183110) /Source="Nicolas_upshift_promotors" /id="U2719" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.98101898101898" /psig="0.98101898101898" /xcortree=516 /SigmaFactorBS="ttctctttggcctgcatcgtatatttagcagtaatAGAGGAC TTtatcactagttTGGATAATAAGCACAGATAaggaggggatgaaaatggcaacattg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3183191) /Source="Nicolas_upshifts" /id="D1792" /incds=0 /nref=134 /ntot=243 /MaxReadThrough="0.22626" /MaxDrop="5.17193" /score="21.4455132" /energy="-10" /TU="NA" /idTUdmin="U2720" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS complement(3183263..3183838) /gene="yvdD" /locus_tag="BSU_34640" /old_locus_tag="BSU34640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_391344.1" /db_xref="EnsemblGenomes-Gn:BSU34640" /db_xref="EnsemblGenomes-Tr:CAB15469" /db_xref="InterPro:IPR005269" /db_xref="InterPro:IPR031100" /db_xref="PDB:1T35" /db_xref="SubtiList:BG12413" /db_xref="UniProtKB/Swiss-Prot:O06986" /translation="MKTICVFAGSNPGGNEAYKRKAAELGVYMAEQGIGLVYGGSRVG LMGTIADAIMENGGTAIGVMPSGLFSGEVVHQNLTELIEVNGMHERKAKMSELADGFI SMPGGFGTYEELFEVLCWAQIGIHQKPIGLYNVNGYFEPMMKMVKYSIQEGFSNESHL KLIHSSSRPDELIEQMQNYSYPILEKKWTEI*" /label="yvdD CDS" gene complement(3183263..3183838) /gene="yvdD" /locus_tag="BSU_34640" /old_locus_tag="BSU34640" /label="yvdD gene" downshifts complement(3183275) /Source="Nicolas_upshifts" /id="D1793" /incds=0 /nref=30 /ntot=209 /MaxReadThrough="4.23893" /MaxDrop="3.6086" /score="21.4455132" /energy="-10" /TU="U2720" /idTUdmin="U2720" /TUdmin="-87" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3183881..3183900) /Source="Nicolas_upshift_promotors" /id="U2720" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.61038961038961" /psig="0.998001998001998" /xcortree=3064 /SigmaFactorBS="caacctcatcactcctgcattctttatgtatttcaTATTGAT AttatcacatgaagaTGGGACAATATATAGTGTGTttttgaatgtttaacacgatata t" /listShort="yvdD" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 3183887..3183894 /Source="Nicolas_upshift_promotors" /id="U2721" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.856143856143856" /psig="0.998001998001998" /xcortree=3065 /SigmaFactorBS="catctccgcatctatatatcgtgttaaacattcaaaaacaca cTATATATTgtcccatcttcaTGTGATAATATCAATATGAAatacataaagaatgcag g" /listShort="yvdC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3183897) /Source="Nicolas_upshifts" /id="U2720" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.61038961038961" /psig="0.998001998001998" /xcortree=3064 /SigmaFactorBS="caacctcatcactcctgcattctttatgtatttcaTATTGAT AttatcacatgaagaTGGGACAATATATAGTGTGTttttgaatgtttaacacgatata t" /listShort="yvdD" /GFF_Attribute="listLong" /label="upshifts" upshifts 3183904 /Source="Nicolas_upshifts" /id="U2721" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.856143856143856" /psig="0.998001998001998" /xcortree=3065 /SigmaFactorBS="catctccgcatctatatatcgtgttaaacattcaaaaacaca cTATATATTgtcccatcttcaTGTGATAATATCAATATGAAatacataaagaatgcag g" /listShort="yvdC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3183907..3183926 /Source="Nicolas_upshift_promotors" /id="U2721" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.856143856143856" /psig="0.998001998001998" /xcortree=3065 /SigmaFactorBS="catctccgcatctatatatcgtgttaaacattcaaaaacaca cTATATATTgtcccatcttcaTGTGATAATATCAATATGAAatacataaagaatgcag g" /listShort="yvdC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3183915..3183922) /Source="Nicolas_upshift_promotors" /id="U2720" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.61038961038961" /psig="0.998001998001998" /xcortree=3064 /SigmaFactorBS="caacctcatcactcctgcattctttatgtatttcaTATTGAT AttatcacatgaagaTGGGACAATATATAGTGTGTttttgaatgtttaacacgatata t" /listShort="yvdD" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3183955..3184275 /gene="yvdC" /locus_tag="BSU_34650" /old_locus_tag="BSU34650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16120674, 19684115; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative pyrophosphohydrolase" /protein_id="NP_391345.1" /db_xref="EnsemblGenomes-Gn:BSU34650" /db_xref="EnsemblGenomes-Tr:CAB15470" /db_xref="InterPro:IPR004518" /db_xref="InterPro:IPR011411" /db_xref="SubtiList:BG12412" /db_xref="UniProtKB/Swiss-Prot:O32263" /translation="MQLADAEKWMKEFYEKRGWTEYGPFIRVGFLMEEAGELARAVRA YEIGRDRPDEKESSRAEQKQELIEEMGDVIGNIAILADMYGVSLEDVMKAHQEKLTKR FEHA*" /label="yvdC CDS" gene 3183955..3184275 /gene="yvdC" /locus_tag="BSU_34650" /old_locus_tag="BSU34650" /label="yvdC gene" downshifts 3184256 /Source="Nicolas_upshifts" /id="D1794" /incds=0 /nref=134 /ntot=247 /MaxReadThrough="2.19085" /MaxDrop="5.46819" /score="35.8658106" /energy="-11.6" /TU="NA" /idTUdmin="U2721" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(3184302) /Source="Nicolas_upshifts" /id="D1795" /incds=0 /nref=13 /ntot=56 /MaxReadThrough="0.462300000000001" /MaxDrop="6.90114" /score="30.4681035" /energy="-11.3" /TU="NA" /idTUdmin="U2722" /TUdmin=8 /isTUend="TRUE" /label="downshifts" CDS complement(3184302..3185894) /gene="yvdB" /locus_tag="BSU_34660" /old_locus_tag="BSU34660" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative anion transporter" /protein_id="NP_391346.1" /db_xref="EnsemblGenomes-Gn:BSU34660" /db_xref="EnsemblGenomes-Tr:CAB15471" /db_xref="GOA:O06984" /db_xref="InterPro:IPR001902" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR011547" /db_xref="InterPro:IPR036513" /db_xref="SubtiList:BG12411" /db_xref="UniProtKB/Swiss-Prot:O06984" /translation="MRFSGRFKGYNLQKFQKDLIAGIVVGVVAIPLGMAFAIASGVEP EYGLYTVVIAGICISLFGGSKYQIGGPTGAFVPILFGIIMQYGLENLLIAGFMAGVML VLFGLFKLGKIMKFVPKPVIVGFTAGIAVLIFTEQIANFLGLRNVEKHENFHHNMFEI VQQLGTFNVYAILTAVIGLVILLVSAKVMPKVPGALLALLISTVVAVVFFPDRMATIG STYGEIPRHLPEFQFPELTLDKMVMLFPAALVIALLGGLESILSAMVADNMKGSKHDS NKELVGQGIANMAAPLFGGIPATGAIARTATNIKNGAVSPVSGVVHGVVVLLVLLVFA PYASHVPLASMAPILMVVAWNMSERKEVANMLRLKNADSFILAATFALTVLFDLIIGV ATGLLLAFVFFIRRMSEATRIHNQETHPVLAKREDPSVSMYAIEGPLFFGSIDSLESS LLEHVQKKPKTLILLMNKVHYMDTSAEAVLGNIMNRIKRHNGKLMIVGLQSQPKELLH KTGLFHKIGKQHFFDHHDEITG*" /label="yvdB CDS" gene complement(3184302..3185894) /gene="yvdB" /locus_tag="BSU_34660" /old_locus_tag="BSU34660" /label="yvdB gene" CDS complement(3185913..3186506) /gene="yvdA" /locus_tag="BSU_34670" /old_locus_tag="BSU34670" /EC_number="4.2.1.1" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10611359; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative carbonic anhydrase" /protein_id="NP_391347.1" /db_xref="EnsemblGenomes-Gn:BSU34670" /db_xref="EnsemblGenomes-Tr:CAB15472" /db_xref="GOA:O06983" /db_xref="InterPro:IPR001765" /db_xref="InterPro:IPR036874" /db_xref="SubtiList:BG12410" /db_xref="UniProtKB/Swiss-Prot:O06983" /translation="MNQMVSLTSILEHNQRFVSEKKYEPYKTTKFPSKKLVIVTCMDT RLTELLPQAMGLKNGDAKIVKNAGAIVSHPFGSVMRSILVAIYELQAEEVCIVGHHEC GMSGLNASSILEKAKERGVEDSCLNLLTSAGLDLKTWLTGFHSVEESVSHSVNMIKNH PLLPKKVPVHGLVIHPETGKLDVVINGYETELINNHS*" /label="yvdA CDS" gene complement(3185913..3186506) /gene="yvdA" /locus_tag="BSU_34670" /old_locus_tag="BSU34670" /label="yvdA gene" promotor_-10 complement(3186548..3186567) /Source="Nicolas_upshift_promotors" /id="U2722" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.38961038961039" /psig="0.98901098901099" /xcortree=371 /SigmaFactorBS="ttctacagtccaattatagtgtctttttttgaaaaCCTTTtc ttggcttattccTATGCTATAATTCCTTACTGtaagctgggtaagaaggcttgcaaaa t" /listShort="yvdA, yvdB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3186561) /Source="Nicolas_upshifts" /id="U2722" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.38961038961039" /psig="0.98901098901099" /xcortree=371 /SigmaFactorBS="ttctacagtccaattatagtgtctttttttgaaaaCCTTTtc ttggcttattccTATGCTATAATTCCTTACTGtaagctgggtaagaaggcttgcaaaa t" /listShort="yvdA, yvdB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3186582..3186586) /Source="Nicolas_upshift_promotors" /id="U2722" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.38961038961039" /psig="0.98901098901099" /xcortree=371 /SigmaFactorBS="ttctacagtccaattatagtgtctttttttgaaaaCCTTTtc ttggcttattccTATGCTATAATTCCTTACTGtaagctgggtaagaaggcttgcaaaa t" /listShort="yvdA, yvdB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3186632..3186637 /Source="Nicolas_upshift_promotors" /id="U2723" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.934065934065934" /psig="0.934065934065934" /xcortree=962 /SigmaFactorBS="aaaaagacactataattggactgtagaatcaaaacataAACA TTtatatctttcaaagaTAATAAAATTTATATTTAAtgcatcctataatccggctgca g" /listShort="yvcT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3186653..3186671 /Source="Nicolas_upshift_promotors" /id="U2723" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.934065934065934" /psig="0.934065934065934" /xcortree=962 /SigmaFactorBS="aaaaagacactataattggactgtagaatcaaaacataAACA TTtatatctttcaaagaTAATAAAATTTATATTTAAtgcatcctataatccggctgca g" /listShort="yvcT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3186654 /Source="Nicolas_upshifts" /id="U2723" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.934065934065934" /psig="0.934065934065934" /xcortree=962 /SigmaFactorBS="aaaaagacactataattggactgtagaatcaaaacataAACA TTtatatctttcaaagaTAATAAAATTTATATTTAAtgcatcctataatccggctgca g" /listShort="yvcT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3186827..3186834 /Source="Nicolas_upshift_promotors" /id="U2724" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74025974025974" /psig=1 /xcortree=1931 /SigmaFactorBS="gttcaaaagaaccagaaattaaaaaaacgcagctaTATTTTT AacatctatttattTTCGATATAATGAATTAGACaacagccataaagggggagccttg t" /listShort="yvcT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3186848..3186867 /Source="Nicolas_upshift_promotors" /id="U2724" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74025974025974" /psig=1 /xcortree=1931 /SigmaFactorBS="gttcaaaagaaccagaaattaaaaaaacgcagctaTATTTTT AacatctatttattTTCGATATAATGAATTAGACaacagccataaagggggagccttg t" /listShort="yvcT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3186852 /Source="Nicolas_upshifts" /id="U2724" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74025974025974" /psig=1 /xcortree=1931 /SigmaFactorBS="gttcaaaagaaccagaaattaaaaaaacgcagctaTATTTTT AacatctatttattTTCGATATAATGAATTAGACaacagccataaagggggagccttg t" /listShort="yvcT" /GFF_Attribute="listLong" /label="upshifts" CDS 3186889..3187866 /gene="yvcT" /locus_tag="BSU_34680" /old_locus_tag="BSU34680" /EC_number="1.1.1.215" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9811658, 25769838; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 2-ketogluconate reductase; hydroxypyruvate / glyoxylate reductase" /protein_id="NP_391348.1" /db_xref="EnsemblGenomes-Gn:BSU34680" /db_xref="EnsemblGenomes-Tr:CAB15473" /db_xref="GOA:O32264" /db_xref="InterPro:IPR006139" /db_xref="InterPro:IPR006140" /db_xref="InterPro:IPR029752" /db_xref="InterPro:IPR029753" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12409" /db_xref="UniProtKB/Swiss-Prot:O32264" /translation="MLKPFVFITKPIPEEIEAFIGEHCRYEVWQEDTLPSDVLFEKLK EAEGLLTSGTSGPSINRELLEHAPKLKVVSNQSVGYDNFDIEAMKERGVVGTHTPYTL DDTVADLAFSLILSSARRVAELDRFVRAGKWGTVEEEALFGIDVHHQTLGIIGMGRIG EQAARRAKFGFDMEVLYHNRHRKQETEDSIGVKYAELDTLLEQSDFILLITPLTDETY HMIGEREFKLMKNSAIFVNISRGKTVDEKALIRALQEGWIRGAGLDVYEKEPVTQDNP LLQLDNVTLLPHIGSATAKVRFNMCKQAAENMLAAIQGQTPKNLTREFQ*" /label="yvcT CDS" gene 3186889..3187866 /gene="yvcT" /locus_tag="BSU_34680" /old_locus_tag="BSU34680" /label="yvcT gene" downshifts 3187838 /Source="Nicolas_upshifts" /id="D1796" /incds=0 /nref=223 /ntot=269 /MaxReadThrough="2.44036" /MaxDrop="5.93476" /score="1.05732532" /energy="-14.7" /TU="NA" /idTUdmin="U2724" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(3187904..3189844) /gene="psdB" /locus_tag="BSU_34690" /old_locus_tag="BSU34690" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 21078927, 27997719" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 21078927, 27997719; Product type t: transporter" /codon_start=1 /transl_table=11 /product="lantibiotic ABC transporter (permease)" /protein_id="NP_391349.1" /db_xref="EnsemblGenomes-Gn:BSU34690" /db_xref="EnsemblGenomes-Tr:CAB15474" /db_xref="GOA:O06981" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR027022" /db_xref="SubtiList:BG12408" /db_xref="UniProtKB/Swiss-Prot:O06981" /translation="MNLRTIARKNILGNLQRYVAYFLSCVFAVSVFFVFTSFIFHPDV NEDNIYGGSLVKTCLSAALVVIIVFCIFFITYSNSAFLQARKKEFGLLTLFGTSKQQL RKMIYYEQSLISLAAIAAGIGAGLLFSKLFFMIMTWMLSVKVPISFAIVPKAFVMTIA GFLILFQTLLILSLGRIRKLEIIELIKSAKKPKSLPVYSKWLTVLSLLCLGSGYYLSA TANAIDMMFRVFPILILVLIGTYFFFTQSSVAFFRMLYRKKHSFYKGTNIIVRSNMIF RLKDHARMLFLTSVITAVILTATGVIYMFYSDLQRQEEQSIPQSVSWVEKDASRFQVM KPETAENTLKKAHAVITYKVDATGIPVTFQSDLPYGNKKMEAEALLISEKVYNQVAKE KGFPVIHLQENEAFINVSFQMMVKDTFGEGETAAFHMKSGKTLSYVMKKQQNKGILMS VDGVSRLLVVSEKSFDSLSQDVPLKEQMRMVGYELEHWQETVDVSEKLENMVPKEHTS DFQTRAPSYQIVKQGVALMLFIGLFVSVLFFIVQGSMLYLRMFTEIEDTGVQVLALKR IGVTDKEIHSILGKQIGFLFFIPFIAGTIHAGFAYAALSNMLNSNLFLEAVIVIFIYF VFQALYYIVTRHIYKRAVLQRM*" /label="psdB CDS" gene complement(3187904..3189844) /gene="psdB" /locus_tag="BSU_34690" /old_locus_tag="BSU34690" /label="psdB gene" downshifts complement(3187928) /Source="Nicolas_upshifts" /id="D1797" /incds=0 /nref=11 /ntot=187 /MaxReadThrough="0.26118" /MaxDrop="4.59213" /score="26.9028733" /energy="-14.7" /TU="NA" /idTUdmin="U2725" /TUdmin=34 /isTUend="FALSE" /label="downshifts" CDS complement(3189819..3190598) /gene="psdA" /locus_tag="BSU_34700" /old_locus_tag="BSU34700" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12432961, 14651641, 21078927, 27997719" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12432961, 14651641, 21078927, 27997719; Product type t: transporter" /codon_start=1 /transl_table=11 /product="lantibiotic ABC transporter (ATP-binding protein)" /protein_id="NP_391350.1" /db_xref="EnsemblGenomes-Gn:BSU34700" /db_xref="EnsemblGenomes-Tr:CAB15475" /db_xref="GOA:O06980" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12407" /db_xref="UniProtKB/Swiss-Prot:O06980" /translation="MNVLQTTNLSKTYYSNKGTISYQALSAFDLSVSKGEFVGIMGPS GSGKTTLLNLLATIDKPTQGEMMINGIQPKTLKDQELALFRRRELGFVFQDFNLLDTL TIRENILLPLALDKVKLREMEARLDELADTLQIKHILDHRTYEVSGGQQQRAACARAI IHNPALILADEPTGNLDSKSAKQVMNTLAQLNEEKEATILLVTHDATAASFCKRIVFI KDGRFFSEIHRGTNRQVFYQSILDTLSVLGGDFHEFENYRP*" /label="psdA CDS" gene complement(3189819..3190598) /gene="psdA" /locus_tag="BSU_34700" /old_locus_tag="BSU34700" /label="psdA gene" S_feature complement(3190599..3190680) /Source="Nicolas_S_feature" /locus_tag="new_3566276_3566357_c" /HighExp="LBGtran, M0t45, H2O2, C30, Lbexp, Lbstat, LBGstat, dia0, Paraq, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 0.997" /TUlongSig="SigA, SigA" /TUlongPSig="1, 0.999" /label="S1321" CDS complement(3190681..3191751) /gene="psdS" /locus_tag="BSU_34710" /old_locus_tag="BSU34710" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 12432961, 14651641, 21078927, 27997719" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 12432961, 14651641, 21078927, 27997719; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [PsdR] response to lantibiotics (nisin and gallidermin)" /protein_id="NP_391351.1" /db_xref="EnsemblGenomes-Gn:BSU34710" /db_xref="EnsemblGenomes-Tr:CAB15476" /db_xref="GOA:O06979" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12406" /db_xref="UniProtKB/Swiss-Prot:O06979" /translation="MLKTYLIDRLAIILFSLLGIGSAMLIAYLSIVESGAEPSKENMM YIWILPGTLLAAGFAADYVRQFSFLTYVKKLAEQASSSNDIGQSLKARKPRTGEQALW TKMINALGQQYESRLSQYINQQKQHYTFTNQWVHHMKTPVSVISLMIQEGKNGTSSSF PTFLEELEDENERFRHGLDMMLQTARLEEFAFDVKPQTFDLAEMVRSLINQEKRQFIK RRLFPTLHVPPNAVQISSDQKWLSFVVEQILFNALKYSKQGVGDPITIRIETQGHETR LSVADEGIGIPPQDLPRIFDAFFTGENGRTMKEATGMGLYLAKQVCSRLGHKLYAESK EGAGTVMTIVFSSDTLVNVTAL*" /label="psdS CDS" gene complement(3190681..3191751) /gene="psdS" /locus_tag="BSU_34710" /old_locus_tag="BSU34710" /label="psdS gene" CDS complement(3191745..3192458) /gene="psdR" /locus_tag="BSU_34720" /old_locus_tag="BSU34720" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 12432961, 14651641, 21078927, 27997719" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 12432961, 14651641, 21078927, 27997719; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [PsdS] responding to lipid II-binding lantibiotics (nisin and gallidermin)" /protein_id="NP_391352.1" /db_xref="EnsemblGenomes-Gn:BSU34720" /db_xref="EnsemblGenomes-Tr:CAB15477" /db_xref="GOA:O06978" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12405" /db_xref="UniProtKB/Swiss-Prot:O06978" /translation="MYRILLVEDDERIASLLGGHLQKYGYEVKIAEQLNDIKLEFAEM KPDLVLLDINLPFFDGFYWCRQIRTISNAPIIFISARTDELNQVMAIENGGDDYITKP FHLEVVMAKIKSVLRRTYGEYSPSLPQESRIVELGGLTIYPDQNEAEWNSVRILFSQK EFQLLSIFVREHKKIVSRDELLEALWDDVDFVDDNTLTVNVNRLRRKLENAGLTDCIS TIRGQGYQFQVNRKDEAEC*" /label="psdR CDS" gene complement(3191745..3192458) /gene="psdR" /locus_tag="BSU_34720" /old_locus_tag="BSU34720" /label="psdR gene" promotor_-10 complement(3192504..3192523) /Source="Nicolas_upshift_promotors" /id="U2725" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2304 /SigmaFactorBS="acctttatcattctatcataacaaaaagaaaaagaccGATTt actattccgcaCATGCTATAATAATTTTGGAatcttctagaaaaatcatcgtgatgta c" /listShort="yvcP, yvcQ, S1321, yvcR, yvcS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3192516) /Source="Nicolas_upshifts" /id="U2725" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2304 /SigmaFactorBS="acctttatcattctatcataacaaaaagaaaaagaccGATTt actattccgcaCATGCTATAATAATTTTGGAatcttctagaaaaatcatcgtgatgta c" /listShort="yvcP, yvcQ, S1321, yvcR, yvcS" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3192518..3192779) /Source="Nicolas_S_feature" /locus_tag="new_3568195_3568456_c" /HighExp="H2O2, G135, G180, Cold, Paraq, G150, dia15, Oxctl, LBGexp, C30" /AntisenseName="yvzJ" /AntisenseCor="0.56014644713727801" /AntisenseRegPval="-22.9" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.997" /TUlongSig="SigA, SigA" /TUlongPSig="1, 0.999" /label="S1322" promotor_-35 complement(3192536..3192539) /Source="Nicolas_upshift_promotors" /id="U2725" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2304 /SigmaFactorBS="acctttatcattctatcataacaaaaagaaaaagaccGATTt actattccgcaCATGCTATAATAATTTTGGAatcttctagaaaaatcatcgtgatgta c" /listShort="yvcP, yvcQ, S1321, yvcR, yvcS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3192539..3192546 /Source="Nicolas_upshift_promotors" /id="U2726" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.888111888111888" /psig=1 /xcortree=1902 /SigmaFactorBS="attccaaaattattatagcatgtgcggaatagtaaatCGGTC TTTttctttttgtTATGATAGAATGATAAAGGTaaaattttcataataggcaggtgtc g" /listShort="yvzJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3192557..3192576 /Source="Nicolas_upshift_promotors" /id="U2726" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.888111888111888" /psig=1 /xcortree=1902 /SigmaFactorBS="attccaaaattattatagcatgtgcggaatagtaaatCGGTC TTTttctttttgtTATGATAGAATGATAAAGGTaaaattttcataataggcaggtgtc g" /listShort="yvzJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3192562 /Source="Nicolas_upshifts" /id="U2726" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.888111888111888" /psig=1 /xcortree=1902 /SigmaFactorBS="attccaaaattattatagcatgtgcggaatagtaaatCGGTC TTTttctttttgtTATGATAGAATGATAAAGGTaaaattttcataataggcaggtgtc g" /listShort="yvzJ" /GFF_Attribute="listLong" /label="upshifts" CDS 3192605..3192814 /gene="yvzJ" /locus_tag="BSU_34729" /old_locus_tag="BSU34729" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="YP_003097790.1" /db_xref="EnsemblGenomes-Gn:BSU34729" /db_xref="EnsemblGenomes-Tr:CAX52696" /db_xref="GOA:C0H3R7" /db_xref="UniProtKB/Swiss-Prot:C0H3R7" /translation="MKKIMLFLAMTSILSACQPNYTGKYIEIGDTLTDYTKECFKENE IPYKYEKGKLYIPEDAFDTAIYTCS*" /label="yvzJ CDS" gene 3192605..3192814 /gene="yvzJ" /locus_tag="BSU_34729" /old_locus_tag="BSU34729" /label="yvzJ gene" downshifts 3192792 /Source="Nicolas_upshifts" /id="D1798" /incds=0 /nref=7 /ntot=138 /MaxReadThrough="1.16039" /MaxDrop="3.61604" /score="-5.58790836" /energy="-11.4" /TU="NA" /idTUdmin="U2726" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(3192824) /Source="Nicolas_upshifts" /id="D1799" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="3.16808" /MaxDrop="2.84175" /score="16.7711538" /energy="-11.5" /TU="U2727,U2729" /idTUdmin="U2728" /TUdmin=44 /isTUend="FALSE" /label="downshifts" CDS complement(3192850..3193614) /gene="yvcN" /locus_tag="BSU_34730" /old_locus_tag="BSU34730" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10876241; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative arylamine N-acetyltransferase" /protein_id="NP_391353.1" /db_xref="EnsemblGenomes-Gn:BSU34730" /db_xref="EnsemblGenomes-Tr:CAB15478" /db_xref="GOA:O06977" /db_xref="InterPro:IPR001447" /db_xref="SubtiList:BG12404" /db_xref="UniProtKB/Swiss-Prot:O06977" /translation="MIKMSDFLKDCFQKIGWEKDHVSFGDLPLFLKAMAYRFPFENRA VLAKENYKITKEELWRRLLKDQHGGLCYDLNGFLYFVLREAGFHVKLIRGTVYAGDQE GWALEGTHAAVWLSAENGDYLVDIGFGINLALQPIPLSGETVQSPVGSFRIKKEETEK GSYVLLMDKGEGWQIGYAFTLEESDLGDLDNMKDIIHSHEKSPFNKSLLASKLTPSGR MVMSERHFTIYENGGNIQKSDIGPSGFEEKLNTHFL*" /label="yvcN CDS" gene complement(3192850..3193614) /gene="yvcN" /locus_tag="BSU_34730" /old_locus_tag="BSU34730" /label="yvcN gene" downshifts complement(3192872) /Source="Nicolas_upshifts" /id="D1800" /incds=0 /nref=143 /ntot=253 /MaxReadThrough="3.19848" /MaxDrop="6.45069" /score="16.7711538" /energy="-11.5" /TU="U2727,U2729" /idTUdmin="U2728" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(3193615..3193872) /gene="crh" /locus_tag="BSU_34740" /old_locus_tag="BSU34740" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10559153, 10589728, 1136107, 12972249, 15126459, 16411239, 17142398, 21992469, 22092971" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10559153, 10589728, 1136107, 12972249, 15126459, 16411239, 17142398, 21992469, 22092971; Product type r: regulator" /codon_start=1 /transl_table=11 /product="catabolite repression HPr-like protein" /protein_id="NP_391354.1" /db_xref="EnsemblGenomes-Gn:BSU34740" /db_xref="EnsemblGenomes-Tr:CAB15479" /db_xref="InterPro:IPR000032" /db_xref="InterPro:IPR002114" /db_xref="InterPro:IPR035895" /db_xref="PDB:1K1C" /db_xref="PDB:1MO1" /db_xref="PDB:1MU4" /db_xref="PDB:1ZVV" /db_xref="PDB:2AK7" /db_xref="PDB:2RLZ" /db_xref="SubtiList:BG12403" /db_xref="UniProtKB/Swiss-Prot:O06976" /translation="MVQQKVEVRLKTGLQARPAALFVQEANRFTSDVFLEKDGKKVNA KSIMGLMSLAVSTGTEVTLIAQGEDEQEALEKLAAYVQEEV*" /label="crh CDS" gene complement(3193615..3193872) /gene="crh" /locus_tag="BSU_34740" /old_locus_tag="BSU34740" /label="crh gene" CDS complement(3193896..3194846) /gene="whiA" /locus_tag="BSU_34750" /old_locus_tag="BSU34750" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10986251, 17603302, 19836336, 24097947; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative morphogen" /protein_id="NP_391355.1" /db_xref="EnsemblGenomes-Gn:BSU34750" /db_xref="EnsemblGenomes-Tr:CAB15480" /db_xref="GOA:O06975" /db_xref="InterPro:IPR003802" /db_xref="InterPro:IPR018478" /db_xref="InterPro:IPR023054" /db_xref="InterPro:IPR027434" /db_xref="InterPro:IPR033981" /db_xref="SubtiList:BG12402" /db_xref="UniProtKB/Swiss-Prot:O06975" /translation="MSFASETKKELTNLEVKDCCINAELSALIRMNGALSFTNRHLVL DVQTENAAIARRIYTLLKKQYDVSVELLVRKKMRLKKNNVYIVRFSENAKAILEDLKI LGENFVFERSISKELVKKRCCKRSYMRGAFLAGGSVNNPETSSYHLEIFSLYKEHNDS LCDLLNEFQLNSKTLERKKGYITYLKEAEKITEFLNVIGAHNSLLRFEDVRIVRDMRN SVNRLVNCETANLNKTIGASLRQVENIKYIDERIGLEALPEKLREIAQLRIDYQEVTL KELGEMVASGKISKSGINHRLRKLDEIAEQLRTGQTVTLK*" /label="whiA CDS" gene complement(3193896..3194846) /gene="whiA" /locus_tag="BSU_34750" /old_locus_tag="BSU34750" /label="whiA gene" CDS complement(3194869..3195822) /gene="mgfK" /locus_tag="BSU_34760" /old_locus_tag="BSU34760" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11888293, 16272399, 21320184, 21371139, 25012659, 27806131, 28646159" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11888293, 16272399, 21320184, 21371139, 25012659, 27806131, 28646159; Product type f: factor" /codon_start=1 /transl_table=11 /product="gluconeogenesis morphogenetic factor (UDP-sugar binding)" /protein_id="NP_391356.2" /db_xref="EnsemblGenomes-Gn:BSU34760" /db_xref="EnsemblGenomes-Tr:CAB15481" /db_xref="GOA:O06974" /db_xref="InterPro:IPR002882" /db_xref="InterPro:IPR010119" /db_xref="SubtiList:BG12401" /db_xref="UniProtKB/Swiss-Prot:O06974" /translation="MGQKPKIAIFGGGTGLSVLLRGLKHKPVDITAIVTVADDGGSSG RLRNELKIPPPGDIRNVLAALSDVEPLVEDLFQHRFNKGNDLTGHSLGNLILAAMTNI TGDFFHAVTEMSKVLNVRGKVLPAANASVVLHAEMEDGRVVSGESTIPEYGQRIKRVF LTPEQIDPLPETIDVIREADLIIIGPGSLYTSILPNLLVPKIGEEVIKAPAKKVYICN VMTQPGETLHYTAADHVKALNQHMGCGFIDTILVNSEDIPDEIKRKYEMESARPVDFD IEELKAMGLEVIRDQIVTYKNDVIRHDTHKVASLLVDLLKE*" /label="mgfK CDS" gene complement(3194869..3195822) /gene="mgfK" /locus_tag="BSU_34760" /old_locus_tag="BSU34760" /label="mgfK gene" CDS complement(3195824..3196711) /gene="yvcJ" /locus_tag="BSU_34770" /old_locus_tag="BSU34770" /function="15.6: DNA transformation" /experiment="publication(s) with functional evidences, PMID:18334534, 19074378, 21179021, 21709426" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18334534, 19074378, 21179021, 21709426; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GTPase possibly involved in regulator sRNA degradation" /protein_id="NP_391357.1" /db_xref="EnsemblGenomes-Gn:BSU34770" /db_xref="EnsemblGenomes-Tr:CAB15482" /db_xref="GOA:O06973" /db_xref="InterPro:IPR005337" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12400" /db_xref="UniProtKB/Swiss-Prot:O06973" /translation="MSVSESHDIQLVIITGMSGAGKTVAIQSFEDLGYFCVDNLPPSL LPKFLELMKESNSKMSKVALVMDLRGREFFDRLIEALDEMAENPWITPRILFLDAKDS ILVTRYKETRRSHPLAATGLPLEGIALERELLEELKGRSQIIYDTSDMKPRDLREKIV KHFATNQGETFTVNVMSFGFKYGIPIDADLVFDVRFLPNPYYIESMRPLTGKDKEVSS YVMKWNETQKFNEKLIDLLSFMLPSYKREGKSQVVIAIGCTGGQHRSVTLAENLADYF KKDYYTHVTHRDIEKRSRK*" /label="yvcJ CDS" gene complement(3195824..3196711) /gene="yvcJ" /locus_tag="BSU_34770" /old_locus_tag="BSU34770" /label="yvcJ gene" CDS complement(3196736..3197212) /gene="yvcI" /locus_tag="BSU_34780" /old_locus_tag="BSU34780" /EC_number="3.6.-.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative triphosphate pyrophosphate hydrolase" /protein_id="NP_391358.1" /db_xref="EnsemblGenomes-Gn:BSU34780" /db_xref="EnsemblGenomes-Tr:CAB15483" /db_xref="GOA:O06972" /db_xref="InterPro:IPR000086" /db_xref="InterPro:IPR015797" /db_xref="InterPro:IPR020476" /db_xref="SubtiList:BG12399" /db_xref="UniProtKB/Swiss-Prot:O06972" /translation="MTYLQRVTNCVLQTDDKVLLLQKPRRGWWVAPGGKMESGESVRD SVIREYREETGIYIINPQLKGVFTFIIKDGDHIVSEWMMFTFVADSYTGQNVSESEEG KLQWHDVNDIQNLPMAPGDGHILDFMMKGQGLLHGTFTYTPEFELLSYRLDPQHIK*" /label="yvcI CDS" gene complement(3196736..3197212) /gene="yvcI" /locus_tag="BSU_34780" /old_locus_tag="BSU34780" /label="yvcI gene" promotor_-10 complement(3197232..3197251) /Source="Nicolas_upshift_promotors" /id="U2727" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.588411588411588" /psig=1 /xcortree=2664 /SigmaFactorBS="ctgtaaaatagaagaaaagattgtcaatgtctcttCATTGtg ggaggcatcttgaAGCGGTATAATAAAGAGACGatgacaggacgaaggttaggtgacg t" /listShort="yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3197246) /Source="Nicolas_upshifts" /id="U2727" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.588411588411588" /psig=1 /xcortree=2664 /SigmaFactorBS="ctgtaaaatagaagaaaagattgtcaatgtctcttCATTGtg ggaggcatcttgaAGCGGTATAATAAAGAGACGatgacaggacgaaggttaggtgacg t" /listShort="yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3197267..3197271) /Source="Nicolas_upshift_promotors" /id="U2727" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.588411588411588" /psig=1 /xcortree=2664 /SigmaFactorBS="ctgtaaaatagaagaaaagattgtcaatgtctcttCATTGtg ggaggcatcttgaAGCGGTATAATAAAGAGACGatgacaggacgaaggttaggtgacg t" /listShort="yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3197290..3197309) /Source="Nicolas_upshift_promotors" /id="U2728" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.572427572427572" /psig="0.982017982017982" /xcortree=1583 /SigmaFactorBS="ataaataaaagagaattccagttacagcaaaatcatCTGAat taaggaatgaatATGCTGTAAAATAGAAGAAAagattgtcaatgtctcttcattgtgg g" /listShort="yvcI, yvcJ, yvcK, whiA, crh, yvcN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3197303) /Source="Nicolas_upshifts" /id="U2728" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.572427572427572" /psig="0.982017982017982" /xcortree=1583 /SigmaFactorBS="ataaataaaagagaattccagttacagcaaaatcatCTGAat taaggaatgaatATGCTGTAAAATAGAAGAAAagattgtcaatgtctcttcattgtgg g" /listShort="yvcI, yvcJ, yvcK, whiA, crh, yvcN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3197324..3197327) /Source="Nicolas_upshift_promotors" /id="U2728" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.572427572427572" /psig="0.982017982017982" /xcortree=1583 /SigmaFactorBS="ataaataaaagagaattccagttacagcaaaatcatCTGAat taaggaatgaatATGCTGTAAAATAGAAGAAAagattgtcaatgtctcttcattgtgg g" /listShort="yvcI, yvcJ, yvcK, whiA, crh, yvcN" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3197379..3197529) /Source="Nicolas_S_feature" /locus_tag="new_3573056_3573206_c" /HighExp="dia15, Diami, dia5, H2O2, Etha, LPhT, Cold, Paraq, C30, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 1" /TUlongSig="SigA" /TUlongPSig="0.999" /label="S1323" downshifts complement(3197422) /Source="Nicolas_upshifts" /id="D1801" /incds=0 /nref=9 /ntot=78 /MaxReadThrough="6.94979" /MaxDrop="3.73811" /score="11.9453839" /energy="-11" /TU="U2729,U2733" /idTUdmin="U2734" /TUdmin=2904 /isTUend="FALSE" /label="downshifts" CDS complement(3197530..3198480) /gene="trxB" /locus_tag="BSU_34790" /old_locus_tag="BSU34790" /EC_number="1.8.1.9" /function="16.6: Maintain" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14597697, 15659166, 23813734, 24401092" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14597697, 15659166, 23813734, 24401092; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thioredoxin reductase" /protein_id="NP_391359.1" /db_xref="EnsemblGenomes-Gn:BSU34790" /db_xref="EnsemblGenomes-Tr:CAB15484" /db_xref="GOA:P80880" /db_xref="InterPro:IPR000103" /db_xref="InterPro:IPR005982" /db_xref="InterPro:IPR008255" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG12398" /db_xref="UniProtKB/Swiss-Prot:P80880" /translation="MSEEKIYDVIIIGAGPAGMTAAVYTSRANLSTLMIERGIPGGQM ANTEDVENYPGFESILGPELSNKMFEHAKKFGAEYAYGDIKEVIDGKEYKVVKAGSKE YKARAVIIAAGAEYKKIGVPGEKELGGRGVSYCAVCDGAFFKGKELVVVGGGDSAVEE GVYLTRFASKVTIVHRRDKLRAQSILQARAFDNEKVDFLWNKTVKEIHEENGKVGNVT LVDTVTGEESEFKTDGVFIYIGMLPLSKPFENLGITNEEGYIETNDRMETKVEGIFAA GDIREKSLRQIVTATGDGSIAAQSVQHYVEELQETLKTLK*" /label="trxB CDS" gene complement(3197530..3198480) /gene="trxB" /locus_tag="BSU_34790" /old_locus_tag="BSU34790" /label="trxB gene" S_feature complement(3198481..3198568) /Source="Nicolas_S_feature" /locus_tag="new_3574158_3574245_c" /HighExp="dia5, Diami, dia15, H2O2, Etha, Salt, Cold, Paraq, LPhT, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 1" /TUlongSig="SigA" /TUlongPSig="0.999" /label="S1324" promotor_-10 complement(3198557..3198576) /Source="Nicolas_upshift_promotors" /id="U2729" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.507492507492508" /psig="0.997002997002997" /xcortree=2036 /SigmaFactorBS="ttttcgaatacatttaatcgtgttgagcaaaaaaATAGcgta tcaccatgagATTTTATAGGATATGGGTAAggaatacgtttgatggggattcttatct t" /listShort="S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3198568) /Source="Nicolas_upshifts" /id="U2729" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.507492507492508" /psig="0.997002997002997" /xcortree=2036 /SigmaFactorBS="ttttcgaatacatttaatcgtgttgagcaaaaaaATAGcgta tcaccatgagATTTTATAGGATATGGGTAAggaatacgtttgatggggattcttatct t" /listShort="S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3198570..3198661) /Source="Nicolas_S_feature" /locus_tag="new_3574247_3574338_c" /HighExp="Cold, Oxctl, G180, G135, Paraq, C30, LBGexp, G150, S1, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.999" /label="S1325" promotor_-35 complement(3198591..3198594) /Source="Nicolas_upshift_promotors" /id="U2729" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.507492507492508" /psig="0.997002997002997" /xcortree=2036 /SigmaFactorBS="ttttcgaatacatttaatcgtgttgagcaaaaaaATAGcgta tcaccatgagATTTTATAGGATATGGGTAAggaatacgtttgatggggattcttatct t" /listShort="S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3198609..3198615 /Source="Nicolas_upshift_promotors" /id="U2730" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=199 /SigmaFactorBS="gtgatacgctatttttttgctcaacaCGATTAAatgtattcg aaaaGGGTATATGTTAATAAAGAaagagccttctgtttatagaaggcccttgtcatat t" /listShort="S1326" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3198629..3198647 /Source="Nicolas_upshift_promotors" /id="U2730" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=199 /SigmaFactorBS="gtgatacgctatttttttgctcaacaCGATTAAatgtattcg aaaaGGGTATATGTTAATAAAGAaagagccttctgtttatagaaggcccttgtcatat t" /listShort="S1326" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3198643 /Source="Nicolas_upshifts" /id="U2730" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=199 /SigmaFactorBS="gtgatacgctatttttttgctcaacaCGATTAAatgtattcg aaaaGGGTATATGTTAATAAAGAaagagccttctgtttatagaaggcccttgtcatat t" /listShort="S1326" /GFF_Attribute="listLong" /label="upshifts" S_feature 3198644..3202030 /Source="Nicolas_S_feature" /locus_tag="new_3574321_3577707" /HighExp="Sw, M9-stat, B60, T0.30H, Gly, BC, B36, T1.0H, Salt, C30" /AntisenseName="yvcD" /AntisenseCor="-0.261780844003138" /AntisenseRegPval="-4.9000000000000004" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1326" CDS complement(3198686..3200107) /gene="cwlO" /locus_tag="BSU_34800" /old_locus_tag="BSU34800" /EC_number="3.4.-.-" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15187182, 16233686, 21478646, 22139507, 23855774, 24163346, 24769902" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15187182, 16233686, 21478646, 22139507, 23855774, 24163346, 24769902; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="secreted cell wall DL-endopeptidase" /protein_id="NP_391360.1" /db_xref="EnsemblGenomes-Gn:BSU34800" /db_xref="EnsemblGenomes-Tr:CAB15485" /db_xref="GOA:P40767" /db_xref="InterPro:IPR000064" /db_xref="SubtiList:BG11023" /db_xref="UniProtKB/Swiss-Prot:P40767" /translation="MRKSLITLGLASVIGTSSFLIPFTSKTASAETLDEKKQKIESKQ SEVASSIEAKEKELTELQENQSKIEKELKDINDKALDTSNKIEDKKEENDKTKEEIKK LKKEIKETEARIEKRNEILKKRVRSLQESGGSQGYIDVLLGSTSFGDFISRATAVSSI VDADKDLIKQQEQDKAKLEDSEADLNDKLKEVQAALAKLETMQKDLDKQLNEKDKLFD EAKASQKKTAKAISELKSEASELANQKANTEAEQARIKKEQEAAAALIKKQEEAQKAS DETQTDDSQTATTESSKASSSDDSSDNSSDNSSNGSSNSSSNGSSSKKSSGSNSNSGG TVISNSGGIEGAISVGSSIVGQSPYKFGGGRTQSDINNRIFDCSSFVRWAYASAGVNL GPVGGTTTDTLVGRGQAVSASEMKRGDLVFFDTYKTNGHVGIYLGNGTFLNDNTSHGV SVDSMSNPYWKAAFKGVVRRVVQ*" /label="cwlO CDS" gene complement(3198686..3200107) /gene="cwlO" /locus_tag="BSU_34800" /old_locus_tag="BSU34800" /label="cwlO gene" downshifts complement(3198706) /Source="Nicolas_upshifts" /id="D1802" /incds=0 /nref=8 /ntot=106 /MaxReadThrough="6.31311" /MaxDrop="3.4602" /score="1.76249731" /energy="-12.1" /TU="U2733" /idTUdmin="U2734" /TUdmin=1620 /isTUend="FALSE" /label="downshifts" downshifts complement(3198830) /Source="Nicolas_upshifts" /id="D1803" /incds=1 /nref=1 /ntot=20 /MaxReadThrough="7.07718" /MaxDrop="2.13349" /score="1.76249731" /energy="-12.1" /TU="U2733" /idTUdmin="U2734" /TUdmin=1496 /isTUend="FALSE" /label="downshifts" misc_feature 3199734..3199738 /Source="Nicolas_upshift_promotors" /id="U2731" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.963036963036963" /psig="0.002997002997003" /xcortree=52 /SigmaFactorBS="aaagaacatctatgtatccttgagatccgccgctttcctgta aagaacgaACGCGttttttcaggatttcattgcgtttttcgatgcgtgcttcagtttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3199744 /Source="Nicolas_upshifts" /id="U2731" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.963036963036963" /psig="0.002997002997003" /xcortree=52 /SigmaFactorBS="aaagaacatctatgtatccttgagatccgccgctttcctgta aagaacgaACGCGttttttcaggatttcattgcgtttttcgatgcgtgcttcagtttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 3200023..3200027 /Source="Nicolas_upshift_promotors" /id="U2732" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.84015984015984" /psig="0.130869130869131" /xcortree=42 /SigmaFactorBS="ctcagattgcttgctttcgattttttgtttcttttcatctaa tgtttccgccgATGCAgttttacttgtaaatgggatcaaaaaactgcttgtcccgatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3200030 /Source="Nicolas_upshifts" /id="U2732" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.84015984015984" /psig="0.130869130869131" /xcortree=42 /SigmaFactorBS="ctcagattgcttgctttcgattttttgtttcttttcatctaa tgtttccgccgATGCAgttttacttgtaaatgggatcaaaaaactgcttgtcccgatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3200108..3200305) /Source="Nicolas_S_feature" /locus_tag="new_3575785_3575982_c" /HighExp="S1, Cold, T-3.40H, M9-exp, MG t5, MG 5, MG 15, T-5.40H, GM-0.2, MG-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.999" /label="S1327" downshifts 3200228 /Source="Nicolas_upshifts" /id="D1804" /incds=0 /nref=2 /ntot=119 /MaxReadThrough="6.41604" /MaxDrop="3.8522" /score="6.14322693" /energy="-7.6" /TU="U2730,U2731" /idTUdmin="U2731" /TUdmin="-1408" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3200293..3200312) /Source="Nicolas_upshift_promotors" /id="U2733" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.431568431568432" /psig=1 /xcortree=2537 /SigmaFactorBS="catctgtttgaaacataaatgtaataaaatttatCGCTAATT tgtcgaaacttGATGGTATAATGATTCTCGTacataaggaattagtgttttttacata t" /listShort="S1327, cwlO, S1325, S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN" /listLong="S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /label="promotor_-10" upshifts complement(3200305) /Source="Nicolas_upshifts" /id="U2733" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.431568431568432" /psig=1 /xcortree=2537 /SigmaFactorBS="catctgtttgaaacataaatgtaataaaatttatCGCTAATT tgtcgaaacttGATGGTATAATGATTCTCGTacataaggaattagtgttttttacata t" /listShort="S1327, cwlO, S1325, S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN" /listLong="S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /label="upshifts" promotor_-35 complement(3200324..3200331) /Source="Nicolas_upshift_promotors" /id="U2733" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.431568431568432" /psig=1 /xcortree=2537 /SigmaFactorBS="catctgtttgaaacataaatgtaataaaatttatCGCTAATT tgtcgaaacttGATGGTATAATGATTCTCGTacataaggaattagtgttttttacata t" /listShort="S1327, cwlO, S1325, S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN" /listLong="S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /label="promotor_-35" CDS complement(3200488..3201942) /gene="yvcD" /locus_tag="BSU_34810" /old_locus_tag="BSU34810" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391361.1" /db_xref="EnsemblGenomes-Gn:BSU34810" /db_xref="EnsemblGenomes-Tr:CAB15486" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="SubtiList:BG12396" /db_xref="UniProtKB/Swiss-Prot:O06968" /translation="MGKHTSEHKNHAQIVQLLQDGQYFFHKGLKAYKERNLKRASKLI QRAVHLEPEDSEMLSQLAVIYSEMGQYQESNDLLDYIMANLEAEMPECHYFKANNFAH LGLFQEAYKEAAAYSDADPDGEFAEENDSLLDLLDLGDDGIEDSLYDQDELLVKQDRA KSLLESGQLAEAVAALEEITTEYPELWSAYNNLALAYFYSGNVVKAKQTAYEVLSHNE GNLHALCNLLVFYYYEREDEKVAELSDQLSNVYPMLLEQRYKLGATLALVGRYEIGYK WLKSLYKTGFEGDDTFFYWLSCSAYFTGHTDFAETIWRKVESQYPGEDRPAPWIERRE ALPSSVEQRLAAYYISSTKGETEHLEAVIRSKRITAPFETHFVKLLLNGDSAAADVSE DALFAYQTVKLLEQAEKEEMKTEVMSCWVFHVIQQIRAAAPLKNEKGWAAAICYIWKE AHGKQDTKKDTAARFGISPATLTKYMKYIDDILE*" /label="yvcD CDS" gene complement(3200488..3201942) /gene="yvcD" /locus_tag="BSU_34810" /old_locus_tag="BSU34810" /label="yvcD gene" downshifts complement(3200508) /Source="Nicolas_upshifts" /id="D1805" /incds=0 /nref=11 /ntot=190 /MaxReadThrough="3.36188" /MaxDrop="3.98985" /score="16.3455178" /energy="-9.1" /TU="U2734" /idTUdmin="U2734" /TUdmin="-182" /isTUend="FALSE" /label="downshifts" S_feature complement(3201943..3202067) /Source="Nicolas_S_feature" /locus_tag="new_3577620_3577744_c" /HighExp="LBGstat, Sw, Cold, BC, BI, Lbexp, dia0, G150, LBGtran, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1328" downshifts 3201988 /Source="Nicolas_upshifts" /id="D1806" /incds=0 /nref=4 /ntot=36 /MaxReadThrough="1.81602" /MaxDrop="3.41181" /score="7.59889121" /energy="-9.9" /TU="NA" /idTUdmin="U2730" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3202068..3203837) /gene="bmrA" /locus_tag="BSU_34820" /old_locus_tag="BSU34820" /EC_number="3.6.3.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16405427, 18215075, 21077936, 22711831, 24630999" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16405427, 18215075, 21077936, 22711831, 24630999; Product type t : transporter" /codon_start=1 /transl_table=11 /product="efflux transporter (ATP-binding and permease protein)" /protein_id="NP_391362.1" /db_xref="EnsemblGenomes-Gn:BSU34820" /db_xref="EnsemblGenomes-Tr:CAB15487" /db_xref="GOA:O06967" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG12395" /db_xref="UniProtKB/Swiss-Prot:O06967" /translation="MPTKKQKSKSKLKPFFALVRRTNPSYGKLAFALALSVVTTLVSL LIPLLTKQLVDGFSMSNLSGTQIGLIALVFFVQAGLSAYATYALNYNGQKIISGLREL LWKKLIKLPVSYFDTNASGETVSRVTNDTMVVKELITTHISGFITGIISVIGSLTILF IMNWKLTLLVLVVVPLAALILVPIGRKMFSISRETQDETARFTGLLNQILPEIRLVKA SNAEDVEYGRGKMGISSLFKLGVREAKVQSLVGPLISLVLMAALVAVIGYGGMQVSSG ELTAGALVAFILYLFQIIMPMGQITTFFTQLQKSIGATERMIEILAEEEEDTVTGKQI ENAHLPIQLDRVSFGYKPDQLILKEVSAVIEAGKVTAIVGPSGGGKTTLFKLLERFYS PTAGTIRLGDEPVDTYSLESWREHIGYVSQESPLMSGTIRENICYGLERDVTDAEIEK AAEMAYALNFIKELPNQFDTEVGERGIMLSGGQRQRIAIARALLRNPSILMLDEATSS LDSQSEKSVQQALEVLMEGRTTIVIAHRLSTVVDADQLLFVEKGEITGRGTHHELMAS HGLYRDFAEQQLKMNADLENKAG*" /label="bmrA CDS" gene complement(3202068..3203837) /gene="bmrA" /locus_tag="BSU_34820" /old_locus_tag="BSU34820" /label="bmrA gene" S_feature complement(3203838..3203912) /Source="Nicolas_S_feature" /locus_tag="new_3579515_3579589_c" /HighExp="LBGstat, Cold, Lbexp, G150, Oxctl, dia0, T1.30H, T0.30H, BC, T1.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1329" misc_feature complement(3203901..3203920) /Source="Nicolas_upshift_promotors" /id="U2734" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.756243756243756" /psig="0.999000999001" /xcortree=2142 /SigmaFactorBS="gggagatttttattttgatcacggcaaaaatatactgaaaaa gtctttctccATTGATATGATTGAGAAAGAgtaaaaatcatccttttgctatgacttt t" /listShort="S1329, bmrA, S1328, yvcD" /listLong="S1327, cwlO, S1325, S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3203912) /Source="Nicolas_upshifts" /id="U2734" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.756243756243756" /psig="0.999000999001" /xcortree=2142 /SigmaFactorBS="gggagatttttattttgatcacggcaaaaatatactgaaaaa gtctttctccATTGATATGATTGAGAAAGAgtaaaaatcatccttttgctatgacttt t" /listShort="S1329, bmrA, S1328, yvcD" /listLong="S1327, cwlO, S1325, S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /label="upshifts" CDS complement(3204002..3204361) /gene="yvzA" /locus_tag="BSU_34830" /old_locus_tag="BSU34830" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391363.1" /db_xref="EnsemblGenomes-Gn:BSU34830" /db_xref="EnsemblGenomes-Tr:CAB15488" /db_xref="SubtiList:BG14157" /db_xref="UniProtKB/Swiss-Prot:O32265" /translation="MTSLFSESETEIVSTTYMFLTQDEMKGKAGTLNQPINDFLSLTK KFESSLKEEIKGQKGLIVKKIKKELESNSEKRKAALQMIKEEHTAKVDRYKMIIEDLR QQDVTLTYRKKKPVKDV*" /label="yvzA CDS" gene complement(3204002..3204361) /gene="yvzA" /locus_tag="BSU_34830" /old_locus_tag="BSU34830" /label="yvzA gene" downshifts complement(3204022) /Source="Nicolas_upshifts" /id="D1807" /incds=0 /nref=146 /ntot=246 /MaxReadThrough="2.52417" /MaxDrop="4.81771" /score="18.5636016" /energy="-13.2" /TU="NA" /idTUdmin="U2735" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3204376..3206286) /gene="yvcB" /locus_tag="BSU_34840" /old_locus_tag="BSU34840" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391364.1" /db_xref="EnsemblGenomes-Gn:BSU34840" /db_xref="EnsemblGenomes-Tr:CAB15489" /db_xref="SubtiList:BG12394" /db_xref="UniProtKB/Swiss-Prot:O06966" /translation="MGNKNVFENENVKLRLIDLEYDYKQKFASTIASEVKKAKKDFEA DIRRIYKEETHHDLPENMKIEIYTSNELVNQNTSIQSSTRESGYDGTAIHIIDEKKHI DQLQIISEGSADNKDWSYNFFGLFLGIDHSQYEATKEFTNKAKKAAGNSEDLKTFALG HSLANNNQVMVQLIDGEYDEVYGVNGAQVNIDQLLETDESLYRYVIRKFSYKYEDIDS IPPEKLKKEIQKYYEDKGVTTNITQRISKDDPLYGVSGKADFITFGDVKMADTNTSVK GIRNIMDGVPDEDVRSIQKFLQKYKDDYEKDGLNGFIKAASGIDIDLIEKVKNTDGAL KKVSVLYEHFDDVKQMYGRIKEELPSFLGFLHTLLRNSGPVVDQLAENGYIDETQKKV IKKELTNINASMRGIESRYEHFIDHLKHGQFMQALKDVGEIVDYVKSILSSLKTLDTE TKDALKLIVDGHSIVQMLNALSKEKGFSYKGSDIYFTGKSGSGETIQVNLSSAVRIYQ NGMKIVEDMEDAISKYQKVYSQEIDEDFIDKKQAIITAIHHMEENPSHYAFDLQFRLA AGFSHTFDKLEKISVHESFHTGALPANDGIVAELKKQTTEKRDFIKNIRESIEKLFEK EEMISQLFDFQS*" /label="yvcB CDS" gene complement(3204376..3206286) /gene="yvcB" /locus_tag="BSU_34840" /old_locus_tag="BSU34840" /label="yvcB gene" CDS complement(3206288..3207013) /gene="yvcA" /locus_tag="BSU_34850" /old_locus_tag="BSU34850" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17590234; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_391365.1" /db_xref="EnsemblGenomes-Gn:BSU34850" /db_xref="EnsemblGenomes-Tr:CAB15490" /db_xref="GOA:O06965" /db_xref="SubtiList:BG12393" /db_xref="UniProtKB/Swiss-Prot:O06965" /translation="MKKIIFICFSLLLALTGGCSMNDNDKNSTNDNKTEAVKPKDMDP KDLPQVPAFQDEKTREYMVSTKEEEPGYYLLESKLKGFRMLFPEDGKYLSRRSSLTGK NKESIGFNSYDKDTNVMFDGHVTYYKEESFANEPKTMLDIVSGKNDYKGEYKKSSKKK TDIYTAKKKDIFDDIDRKYNYSYSYFGYVKSTEEDNLGVEYAFTLGCKNENQPCSLDE EKAKNKVEKLINSITFLIDKKEK*" /label="yvcA CDS" gene complement(3206288..3207013) /gene="yvcA" /locus_tag="BSU_34850" /old_locus_tag="BSU34850" /label="yvcA gene" S_feature complement(3207014..3207102) /Source="Nicolas_S_feature" /locus_tag="new_3582691_3582779_c" /HighExp="T1.30H, T0.30H, T1.0H, T2.0H, T2.30H, T3.0H, T-1.40H, T-1.10H, MG 150, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.982, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1330" promotor_-10 complement(3207102..3207121) /Source="Nicolas_upshift_promotors" /id="U2735" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.446553446553447" /psig="0.982017982017982" /xcortree=2982 /SigmaFactorBS="tcaaaaccgagtctcatttcctATTTatccaaattccgccaT GATGTAACATGAAAAAGGAtgaaataatcatctcttaaccaggtcaatagaattattt t" /listShort="S1330, yvcA, yvcB, yvzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3207102) /Source="Nicolas_upshifts" /id="U2735" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.446553446553447" /psig="0.982017982017982" /xcortree=2982 /SigmaFactorBS="tcaaaaccgagtctcatttcctATTTatccaaattccgccaT GATGTAACATGAAAAAGGAtgaaataatcatctcttaaccaggtcaatagaattattt t" /listShort="S1330, yvcA, yvcB, yvzA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3207104..3207233) /Source="Nicolas_S_feature" /locus_tag="new_3582781_3582910_c" /HighExp="Etha, Diami, HiTm, T1.0H, Cold, MG 15, T0.30H, BMM, T1.30H, MG 10" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1331" promotor_-35 complement(3207137..3207140) /Source="Nicolas_upshift_promotors" /id="U2735" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.446553446553447" /psig="0.982017982017982" /xcortree=2982 /SigmaFactorBS="tcaaaaccgagtctcatttcctATTTatccaaattccgccaT GATGTAACATGAAAAAGGAtgaaataatcatctcttaaccaggtcaatagaattattt t" /listShort="S1330, yvcA, yvcB, yvzA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3207259..3207888) /gene="hisIE" /locus_tag="BSU_34860" /old_locus_tag="BSU34860" /EC_number="3.5.4.19" /EC_number="3.6.1.31" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15871048, 17767732; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional phosphoribosyl-AMP cyclohydrolase; phosphoribosyl-ATP pyrophosphohydrolase" /protein_id="NP_391366.1" /db_xref="EnsemblGenomes-Gn:BSU34860" /db_xref="EnsemblGenomes-Tr:CAB15491" /db_xref="GOA:O34912" /db_xref="InterPro:IPR002496" /db_xref="InterPro:IPR008179" /db_xref="InterPro:IPR021130" /db_xref="InterPro:IPR023019" /db_xref="InterPro:IPR026660" /db_xref="SubtiList:BG12603" /db_xref="UniProtKB/Swiss-Prot:O34912" /translation="MKQADELRFNEDGLIPAIVQDAASKEVLTLAYMNKESYEKTLET KETWFYSRSRQALWHKGETSGNTQAVKGIRYDCDQDALLVLVEPSGPACHTGSYSCFT KEQTEEQAADRFGIMNELERVIAERQAEMPEGAYTTYLFREGVDKILKKVGEEASEVI IAAKNRDHEELKWEAADLLYHLLVLLREQSLPLDDVLDVLKKRHSEIEE*" /label="hisIE CDS" gene complement(3207259..3207888) /gene="hisIE" /locus_tag="BSU_34860" /old_locus_tag="BSU34860" /label="hisIE gene" downshifts complement(3207278) /Source="Nicolas_upshifts" /id="D1808" /incds=0 /nref=104 /ntot=178 /MaxReadThrough="4.37156" /MaxDrop="4.76747" /score="14.9565762" /energy="-8.4" /TU="U2738" /idTUdmin="U2735" /TUdmin="-3256" /isTUend="FALSE" /label="downshifts" CDS complement(3207885..3208643) /gene="hisF" /locus_tag="BSU_34870" /old_locus_tag="BSU34870" /EC_number="4.3.1.-" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1400209, 17767732, 19636909; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="imidazole glycerol phosphate synthase subunit" /protein_id="NP_391367.1" /db_xref="EnsemblGenomes-Gn:BSU34870" /db_xref="EnsemblGenomes-Tr:CAB15492" /db_xref="GOA:O34727" /db_xref="InterPro:IPR004651" /db_xref="InterPro:IPR006062" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="SubtiList:BG12600" /db_xref="UniProtKB/Swiss-Prot:O34727" /translation="MITKRIIPCLDVKEGRVVKGIQFLELKDAGDPVELAEVYDREGA DELVFLDISASHEGRKTMVDVVEQVAAKLAIPFTVGGGINQLSDMKTILRAGADKVSV NTAAVLRPELITEGAEFFGSQCIVLAIDAKYDKESDTYKVYTHGGRKKTDWEVTAWAK EGVKRGAGEILLTSMDSDGEKKGFDHTLTKLVSEAVPVPVIASGGAGNAQHMLEAFTK GEADAALAASIFHYKETSIKEVKSYLKEYGVNVR*" /label="hisF CDS" gene complement(3207885..3208643) /gene="hisF" /locus_tag="BSU_34870" /old_locus_tag="BSU34870" /label="hisF gene" CDS complement(3208640..3209377) /gene="hisA" /locus_tag="BSU_34880" /old_locus_tag="BSU34880" /EC_number="5.3.1.16" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1400209, 26294764; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase" /protein_id="NP_391368.1" /db_xref="EnsemblGenomes-Gn:BSU34880" /db_xref="EnsemblGenomes-Tr:CAB15493" /db_xref="GOA:O35006" /db_xref="InterPro:IPR006062" /db_xref="InterPro:IPR006063" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR023016" /db_xref="SubtiList:BG12597" /db_xref="UniProtKB/Swiss-Prot:O35006" /translation="MSAFTLYPAIDMRNGKCVRLVQGDYNKETIYGDSPYDMAELFEK EGAEWIHLVDLDGAKEGKRVNDRHVIEIAQKLNLKVEIGGGIRSENDVYEYLSAGVER VILGSSAVSNPPFVKKMLKQYGEKIAIGLDARNGFVSTEGWLETSTLKATELGKELAN EGAEVFIFTDIATDGMLSGPNVKSTVELAKETGKSVIASGGVSSVADLEALARNEADG VSGAIIGKALYTNQFTLSEALERVKRK*" /label="hisA CDS" gene complement(3208640..3209377) /gene="hisA" /locus_tag="BSU_34880" /old_locus_tag="BSU34880" /label="hisA gene" CDS complement(3209374..3210012) /gene="hisH" /locus_tag="BSU_34890" /old_locus_tag="BSU34890" /EC_number="2.4.2.-" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:14585832, 15301532" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14585832, 15301532; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="imidazole glycerol phosphate synthase, glutamineamidotransferase subunit" /protein_id="NP_391369.1" /db_xref="EnsemblGenomes-Gn:BSU34890" /db_xref="EnsemblGenomes-Tr:CAB15494" /db_xref="GOA:O34565" /db_xref="InterPro:IPR010139" /db_xref="InterPro:IPR017926" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG12602" /db_xref="UniProtKB/Swiss-Prot:O34565" /translation="MIGVIDYGMGNLYSVSKALERVGVPYFVSEKPEELKEADAFILP GVGSFGDAMDNLGYTKLDQLIHDMVSEGRLLLGICLGMQLLFEESEENGTASGLGLLK GKAVRLKAEDEKGNKLKVPHMGWNRLSFHNESPLLTKTEQGYAYFVHSYYIDGMEENA LLASADYGVRVPAVVGKRNVFGAQFHPEKSSTVGMSILTQFTKMAAEQKVKK*" /label="hisH CDS" gene complement(3209374..3210012) /gene="hisH" /locus_tag="BSU_34890" /old_locus_tag="BSU34890" /label="hisH gene" promotor_no_box 3209870..3209970 /Source="Nicolas_upshift_promotors" /id="U2736" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.973026973026973" /psig="0.000999000999001" /xcortree=24 /SigmaFactorBS="gaaccgactcccggcaaaatgaaagcatcagcttctttcagc tcctccggcttttcagaaacaaaatacggcacgccgacacgttcaagcgcctttgaga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 3209930 /Source="Nicolas_upshifts" /id="U2736" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.973026973026973" /psig="0.000999000999001" /xcortree=24 /SigmaFactorBS="gaaccgactcccggcaaaatgaaagcatcagcttctttcagc tcctccggcttttcagaaacaaaatacggcacgccgacacgttcaagcgcctttgaga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3210013..3210597) /gene="hisB" /locus_tag="BSU_34900" /old_locus_tag="BSU34900" /EC_number="4.2.1.19" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1400209, 24311587; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="imidazoleglycerol-phosphate dehydratase [Mn(II)-dependent]" /protein_id="NP_391370.1" /db_xref="EnsemblGenomes-Gn:BSU34900" /db_xref="EnsemblGenomes-Tr:CAB15495" /db_xref="GOA:O34683" /db_xref="InterPro:IPR000807" /db_xref="InterPro:IPR020565" /db_xref="InterPro:IPR020568" /db_xref="SubtiList:BG12598" /db_xref="UniProtKB/Swiss-Prot:O34683" /translation="MRKAERVRKTNETDIELAFTIDGGGQADIKTDVPFMTHMLDLFT KHGQFDLSINAKGDVDIDDHHTTEDIGICLGQALLEALGDKKGIKRYGSAFVPMDEAL AQVVIDLSNRPHLEMRADFPAAKVGTFDTELVHEFLWKLALEARMNLHVIVHYGTNTH HMIEAVFKALGRALDEATTIDPRVKGIPSTKGML*" /label="hisB CDS" gene complement(3210013..3210597) /gene="hisB" /locus_tag="BSU_34900" /old_locus_tag="BSU34900" /label="hisB gene" CDS complement(3210594..3211877) /gene="hisD" /locus_tag="BSU_34910" /old_locus_tag="BSU34910" /EC_number="1.1.1.23" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10353847, 10353848, 21672513, 24140957; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="histidinol dehydrogenase" /protein_id="NP_391371.1" /db_xref="EnsemblGenomes-Gn:BSU34910" /db_xref="EnsemblGenomes-Tr:CAB15496" /db_xref="GOA:O34651" /db_xref="InterPro:IPR001692" /db_xref="InterPro:IPR012131" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR022695" /db_xref="SubtiList:BG12599" /db_xref="UniProtKB/Swiss-Prot:O34651" /translation="MKIKTISGAERLSLKRSIDAGTEEQRKTVRSIIEDVKANGDQAV RSYTAKFDCIEIDSPLVTKEEFEEAYTSLDSRLLQVIRQAIENIREYHERQLQSSWFY HRKDGTMLGQKVTALDSAGVYVPGGTAAYPSSVLMNVIPALVAGVERIVLVTPPGKDG LLSPGVLVAAAELGIKDIYKMGGAQAIAALAYGTETIEPVDKITGPGNIYVALAKREV FGDVDIDMIAGPSEIVVLADETAIPSEIAADLLSQAEHDKLSSCVFVTDSMALAETVS AEVNKQLETLPRREIAEASVRDYGCIYVAETMVEAIETVNTLAPEHLEIITQSPEALL GSIKHAGAIFLGRYSPEPVGDYFAGPNHVLPTNGTARFSSPLNVTDFQKKSSIISYSQ SAFEEHAESIAAFARLEGLEAHARSIEARERRISK*" /label="hisD CDS" gene complement(3210594..3211877) /gene="hisD" /locus_tag="BSU_34910" /old_locus_tag="BSU34910" /label="hisD gene" CDS complement(3211874..3212515) /gene="hisG" /locus_tag="BSU_34920" /old_locus_tag="BSU34920" /EC_number="2.4.2.17" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10430882, 12269828, 12511575, 14741209, 15660995, 17154531, 21774583, 22989207, 28092443, 28872824; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP phosphoribosyltransferase" /protein_id="NP_391372.1" /db_xref="EnsemblGenomes-Gn:BSU34920" /db_xref="EnsemblGenomes-Tr:CAB15497" /db_xref="GOA:O34520" /db_xref="InterPro:IPR001348" /db_xref="InterPro:IPR013820" /db_xref="InterPro:IPR018198" /db_xref="InterPro:IPR024893" /db_xref="PDB:2VD2" /db_xref="SubtiList:BG12601" /db_xref="UniProtKB/Swiss-Prot:O34520" /translation="MGKLLTMAMPKGRIFEEAAGLLRQAGYRLPEEFEDSRKLIIDVP EENLRFILAKPMDVTTYVEHGVADVGIAGKDVMLEEERDVYEVLDLNISKCHLAVAGL PNTDWSGVAPRIATKYPNVASSYFREQGEQVEIIKLNGSIELAPLIGLADRIVDIVST GQTLKENGLVETEHICDITSRFIVNPVSYRMKDDVIDEMASRLSLVVEGETAK*" /label="hisG CDS" gene complement(3211874..3212515) /gene="hisG" /locus_tag="BSU_34920" /old_locus_tag="BSU34920" /label="hisG gene" CDS complement(3212508..3213683) /gene="hisZ" /locus_tag="BSU_34930" /old_locus_tag="BSU34930" /EC_number="2.4.2.17" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10430882, 12269828, 12511575, 15660995; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="histidyl-tRNA synthetase-like subunit of ATP phophoribosyltransferase" /protein_id="NP_391373.1" /db_xref="EnsemblGenomes-Gn:BSU34930" /db_xref="EnsemblGenomes-Tr:CAB15498" /db_xref="GOA:O34459" /db_xref="InterPro:IPR004516" /db_xref="InterPro:IPR004517" /db_xref="InterPro:IPR006195" /db_xref="SubtiList:BG12606" /db_xref="UniProtKB/Swiss-Prot:O34459" /translation="MFMFEKPHGMRDTLPGLYETKKKVRRSLTDLIDKWGYQFMETPT LEFYDTVGVQSAIEEQQLFKLLDQDGKTLVLRPDMTGPIARVAASKLLKHGHPLRVGY AANVFRAQEREGGRPAEFEQVGVELIGDGTTSADAEVIALVVGALKNAGLASFKIAIG HAGIADALFVEVLGNVERADVLRRFLYEKNYVGYREHVKSLPLSSIDKSRLLELLELR GGIEVCGRAEEIVDSAQGKSVVDELKALWDILEDYGCTENVRLDLNMVSHMSYYTGIL FEVYAENVGFVIGSGGRYNKLLGHFDSPAPATGFGLRIDRLIEALHMKDEPCEIDAVI FSKEQRAQAIAYANEERMKGNKVVLQDLSGIENIDQMTKSFANVTYFIGARKEEQNG* " /label="hisZ CDS" gene complement(3212508..3213683) /gene="hisZ" /locus_tag="BSU_34930" /old_locus_tag="BSU34930" /label="hisZ gene" S_feature complement(3213684..3213761) /Source="Nicolas_S_feature" /locus_tag="new_3589361_3589438_c" /HighExp="Diami, M/G, Etha, BMM, MG 15, MG 10, T-1.10H, T-0.40H, T-1.40H, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1332" promotor_-35 3213727..3213733 /Source="Nicolas_upshift_promotors" /id="U2737" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.956043956043956" /psig="0.995004995004995" /xcortree=2775 /SigmaFactorBS="ccgctgttatcttatgaaggaaaattccgAATCCTTtagttc gctaaTATGATAATATGTTAGCAGAtgaaagaatgaaaatcaacgcttaacttcagta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3213745..3213764 /Source="Nicolas_upshift_promotors" /id="U2737" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.956043956043956" /psig="0.995004995004995" /xcortree=2775 /SigmaFactorBS="ccgctgttatcttatgaaggaaaattccgAATCCTTtagttc gctaaTATGATAATATGTTAGCAGAtgaaagaatgaaaatcaacgcttaacttcagta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(3213745..3213764) /Source="Nicolas_upshift_promotors" /id="U2738" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.486513486513487" /psig=1 /xcortree=2777 /SigmaFactorBS="ggatatttgaactaaaaatatccttactgaagttaagCGTTG ATTttcattctttcaTCTGCTAACATATTATCATAttagcgaactaaaggattcggaa t" /listShort="S1332, hisZ, hisG, hisD, hisB, hisH, hisA, hisF, hisI, S1331, S1330, yvcA, yvcB, yvzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3213758 /Source="Nicolas_upshifts" /id="U2737" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.956043956043956" /psig="0.995004995004995" /xcortree=2775 /SigmaFactorBS="ccgctgttatcttatgaaggaaaattccgAATCCTTtagttc gctaaTATGATAATATGTTAGCAGAtgaaagaatgaaaatcaacgcttaacttcagta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3213761) /Source="Nicolas_upshifts" /id="U2738" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.486513486513487" /psig=1 /xcortree=2777 /SigmaFactorBS="ggatatttgaactaaaaatatccttactgaagttaagCGTTG ATTttcattctttcaTCTGCTAACATATTATCATAttagcgaactaaaggattcggaa t" /listShort="S1332, hisZ, hisG, hisD, hisB, hisH, hisA, hisF, hisI, S1331, S1330, yvcA, yvcB, yvzA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3213777..3213784) /Source="Nicolas_upshift_promotors" /id="U2738" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.486513486513487" /psig=1 /xcortree=2777 /SigmaFactorBS="ggatatttgaactaaaaatatccttactgaagttaagCGTTG ATTttcattctttcaTCTGCTAACATATTATCATAttagcgaactaaaggattcggaa t" /listShort="S1332, hisZ, hisG, hisD, hisB, hisH, hisA, hisF, hisI, S1331, S1330, yvcA, yvcB, yvzA" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 3213893..3213912 /Source="Nicolas_upshift_promotors" /id="U2739" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2160 /SigmaFactorBS="aatcatgaataatgtattaaaggtacgtaatatctcaaattc tttatgtttggCATGCTATAATACAAATCAAatagagaacaaggagataaagatgaaa a" /listShort="yvpB, S1333, pelC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3213900 /Source="Nicolas_upshifts" /id="U2739" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2160 /SigmaFactorBS="aatcatgaataatgtattaaaggtacgtaatatctcaaattc tttatgtttggCATGCTATAATACAAATCAAatagagaacaaggagataaagatgaaa a" /listShort="yvpB, S1333, pelC" /GFF_Attribute="listLong" /label="upshifts" CDS 3213934..3214686 /gene="yvpB" /locus_tag="BSU_34940" /old_locus_tag="BSU34940" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydratase" /protein_id="NP_391374.1" /db_xref="EnsemblGenomes-Gn:BSU34940" /db_xref="EnsemblGenomes-Tr:CAB15499" /db_xref="InterPro:IPR016997" /db_xref="SubtiList:BG14130" /db_xref="UniProtKB/Swiss-Prot:O34735" /translation="MKTLRTLCVLMILSGVIFFGLKIDAKDIDIPFLNSLKKVVSDSD TDSAANSKKELKGSAKPLDVILYNQMDAPRLYNGCEVTSLAMVLNYAGYDVTKNTLAN QVATVPLTYSSGLKGDPNDGFVGDMANGPGLGVYHRPIYQLAKTYAGDKVSDLTGKSI SAVYQQLEKGNPVWVITTANFTPVDNMQTWKTPNGTIEITYSEHSVAVTGYDDKYVYL NDPYGYKNRKTDRTSFEKAWKQMGSQAVVIQK*" /label="yvpB CDS" gene 3213934..3214686 /gene="yvpB" /locus_tag="BSU_34940" /old_locus_tag="BSU34940" /label="yvpB gene" S_feature 3214687..3214925 /Source="Nicolas_S_feature" /locus_tag="new_3590364_3590602" /HighExp="LBGstat, LPhT, Cold, Sw, M/G, G180, G135, LBGtran, G150, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1333" promotor_-10 complement(3214708..3214719) /Source="Nicolas_upshift_promotors" /id="U2740" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=820 /SigmaFactorBS="ggaaaatgaatcgatcttaccgattgatacaaaaAGCATGAa tattgtcgtatttGCTCAGAATAGAgcatagtgaggcttcaggtgtttacttttgaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3214714) /Source="Nicolas_upshifts" /id="U2740" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=820 /SigmaFactorBS="ggaaaatgaatcgatcttaccgattgatacaaaaAGCATGAa tattgtcgtatttGCTCAGAATAGAgcatagtgaggcttcaggtgtttacttttgaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3214734..3214740) /Source="Nicolas_upshift_promotors" /id="U2740" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=820 /SigmaFactorBS="ggaaaatgaatcgatcttaccgattgatacaaaaAGCATGAa tattgtcgtatttGCTCAGAATAGAgcatagtgaggcttcaggtgtttacttttgaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3214926..3215591 /gene="pelC" /locus_tag="BSU_34950" /old_locus_tag="BSU34950" /EC_number="4.2.2.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10658655, 15187182, 16514142, 20000851, 24236123" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10658655, 15187182, 16514142, 20000851, 24236123; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="secreted pectate (polygalacturonate) lyase" /protein_id="NP_391375.1" /db_xref="EnsemblGenomes-Gn:BSU34950" /db_xref="EnsemblGenomes-Tr:CAB15500" /db_xref="GOA:O34310" /db_xref="InterPro:IPR004898" /db_xref="InterPro:IPR011050" /db_xref="InterPro:IPR012334" /db_xref="SubtiList:BG14129" /db_xref="UniProtKB/Swiss-Prot:O34310" /translation="MKKIVSILFMFGLVMGFSQFQPSTVFAADKVVHETIIVPKNTTY DGKGQRFVAGKELGDGSQSENQDPVFRVEDGATLKNVVLGAPAADGVHTYGNVNIQNV KWEDVGEDALTVKKEGKVTIDGGSAQKASDKIFQINKASTFTVKNFTADNGGKFIRQL GGSTFHVDVIIDKCTITNMKEAIFRTDSKTSTVRMTNTRYSNVGQKWIGVQHIYENNN TQF*" /label="pelC CDS" gene 3214926..3215591 /gene="pelC" /locus_tag="BSU_34950" /old_locus_tag="BSU34950" /label="pelC gene" downshifts 3215562 /Source="Nicolas_upshifts" /id="D1809" /incds=0 /nref=85 /ntot=213 /MaxReadThrough="1.40389" /MaxDrop="4.93342" /score="16.0973385" /energy="-14.9" /TU="NA" /idTUdmin="U2739" /TUdmin=176 /isTUend="FALSE" /label="downshifts" CDS complement(3215611..3216129) /gene="hprF" /locus_tag="BSU_34960" /old_locus_tag="BSU34960" /EC_number="2.3.1.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:21761520, 27226549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21761520, 27226549; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dephosphorylated heptaprenylglyceryl phosphate O-acetyltransferase" /protein_id="NP_391376.1" /db_xref="EnsemblGenomes-Gn:BSU34960" /db_xref="EnsemblGenomes-Tr:CAB15501" /db_xref="GOA:O34993" /db_xref="InterPro:IPR001451" /db_xref="InterPro:IPR011004" /db_xref="SubtiList:BG14128" /db_xref="UniProtKB/Swiss-Prot:O34993" /translation="MRKTDRHPVSGANSLWHVYQTVPFLKVVKNFIVIQIARYTPFIG MKNWLYRTFLRMKVGKQTSFALMVMPDIMFPEKISVGTNTIIGYNTTILAHEYLIHEY RIGKVLIGDEVMIGANTTILPGVKIGDGAVVSAGTLVHKDVPDGAFVGGNPMRIIYTK EEMQERLKKSAE*" /label="hprF CDS" gene complement(3215611..3216129) /gene="hprF" /locus_tag="BSU_34960" /old_locus_tag="BSU34960" /label="hprF gene" downshifts complement(3215645) /Source="Nicolas_upshifts" /id="D1810" /incds=0 /nref=245 /ntot=283 /MaxReadThrough="1.27998" /MaxDrop="6.44997" /score="38.2106579" /energy="-14.9" /TU="NA" /idTUdmin="U2741" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(3216133..3216783) /gene="ppaX" /locus_tag="BSU_34970" /old_locus_tag="BSU34970" /EC_number="3.6.1.1" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9465101, 12359880, 12411438, 16182622, 22353596" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9465101, 12359880, 12411438, 16182622, 22353596; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Hpr-associated pyrophosphatase" /protein_id="NP_391377.1" /db_xref="EnsemblGenomes-Gn:BSU34970" /db_xref="EnsemblGenomes-Tr:CAB15502" /db_xref="GOA:Q9JMQ2" /db_xref="InterPro:IPR006439" /db_xref="InterPro:IPR023198" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR023733" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG14127" /db_xref="UniProtKB/Swiss-Prot:Q9JMQ2" /translation="MSDKQVTTILFDLDGTLINTNELIIASFLHTLEHYYPSKYKRED VLAFIGPSLFDTFSSMDPDKCEDMIAMYRAYNHDMHDSLVTEYETVYETLDALKKAGF TLGIVTTKLRDTVNMGLKLTGIGEFFETVVTLDDVTNAKPDPEPVLLALKQLGSEPAE AIMVGDNYHDVLAGKNAGTKTAGVAWTIKGPEMLAKHEPDFMLEKMSDLLQIVGVK*" /label="ppaX CDS" gene complement(3216133..3216783) /gene="ppaX" /locus_tag="BSU_34970" /old_locus_tag="BSU34970" /label="ppaX gene" CDS complement(3216780..3217718) /gene="yvoD" /locus_tag="BSU_34980" /old_locus_tag="BSU34980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 27226549; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein with nucleotide binding domain" /protein_id="NP_391378.1" /db_xref="EnsemblGenomes-Gn:BSU34980" /db_xref="EnsemblGenomes-Tr:CAB15503" /db_xref="GOA:O34382" /db_xref="InterPro:IPR011642" /db_xref="SubtiList:BG14126" /db_xref="UniProtKB/Swiss-Prot:O34382" /translation="MKKIFLAGLAAGFQTTWTLGKVIFPVTLLVTLLQHTPVMDWLVR LITPVMGLFGLSGEAAIPLVLGNMLNLYAGIAGILTLDLSVKEVFILAVMLSFCHNLI IESTVAAKVGIRIGVILAVRIGLAAVSAIVINLIWHGGKETAQYGFIAAKSAAPDSWL GMLAEALTKAGLGVLQLAAIVIPLMIIIQFLRDLGWLYRFSRWLSPFTQLLGMNKNTS MTMVTGLTIGLAYGAGVMIKAVEDDGVSKRDMTLAFIFLVACHAVVEDTLVFIPLGIP VWPLLLIRVTTAVLLTMAIAHTWKKWKPSAVGKEAI*" /label="yvoD CDS" gene complement(3216780..3217718) /gene="yvoD" /locus_tag="BSU_34980" /old_locus_tag="BSU34980" /label="yvoD gene" CDS complement(3217742..3218551) /gene="lgt" /locus_tag="BSU_34990" /old_locus_tag="BSU34990" /EC_number="2.4.99.-" /function="16.5: Explore" /function="16.13: Shape" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10096076, 11425480, 15126458, 15849754, 16850406, 18556788, 27226549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10096076, 11425480, 15126458, 15849754, 16850406, 18556788, 27226549; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="prelipoprotein diacylglycerol transferase" /protein_id="NP_391379.1" /db_xref="EnsemblGenomes-Gn:BSU34990" /db_xref="EnsemblGenomes-Tr:CAB15504" /db_xref="GOA:O34752" /db_xref="InterPro:IPR001640" /db_xref="SubtiList:BG12611" /db_xref="UniProtKB/Swiss-Prot:O34752" /translation="MNEAIEPLNPIAFQLGPLAVHWYGIIIGLGALLGLWIAMRESEK RGLQKDTFIDLVLFAIPIAIICARIYYVAFEWDYYAAHPGEIIKIWKGGIAIHGGLIG AILTGYVFSRVKNLSFWKLADIAAPSILLGQAIGRWGNFMNQEAHGEAVSRAFLENLH LPEFIINQMYINGQYYHPTFLYESLWSFVGVIVLLLLRRANLRRGEMFLIYIIWYSIG RYFIEGMRTDSLMLTDSLRIAQVISIVLIVLAVAAIIFRRVKGYSKERYAE*" /label="lgt CDS" gene complement(3217742..3218551) /gene="lgt" /locus_tag="BSU_34990" /old_locus_tag="BSU34990" /label="lgt gene" CDS complement(3218565..3219497) /gene="hprK" /locus_tag="BSU_35000" /old_locus_tag="BSU35000" /EC_number="2.7.4.-" /EC_number="2.7.11.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10636874, 12009882, 12359875, 12411438, 12779331, 15023355, 16267306, 17878158, 20487301, 21992469, 27226549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10636874, 12009882, 12359875, 12411438, 12779331, 15023355, 16267306, 17878158, 20487301, 21992469, 27226549; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="serine/threonine protein kinase/phosphorylase (pyrophosphate-producing)" /protein_id="NP_391380.1" /db_xref="EnsemblGenomes-Gn:BSU35000" /db_xref="EnsemblGenomes-Tr:CAB15505" /db_xref="GOA:O34483" /db_xref="InterPro:IPR003755" /db_xref="InterPro:IPR011104" /db_xref="InterPro:IPR011126" /db_xref="InterPro:IPR028979" /db_xref="SubtiList:BG14125" /db_xref="UniProtKB/Swiss-Prot:O34483" /translation="MAKVRTKDVMEQFNLELISGEEGINRPITMSDLSRPGIEIAGYF TYYPRERVQLLGKTELSFFEQLPEEEKKQRMDSLCTDVTPAIILSRDMPIPQELIDAS EKNGVPVLRSPLKTTRLSSRLTNFLESRLAPTTAIHGVLVDIYGVGVLITGKSGVGKS ETALELVKRGHRLVADDCVEIRQEDQDTLVGNAPELIEHLLEIRGLGIINVMTLFGAG AVRSNKRITIVMNLELWEQGKQYDRLGLEEETMKIIDTEITKLTIPVRPGRNLAVIIE VAAMNFRLKRMGLNAAEQFTNKLADVIEDGEQEE*" /label="hprK CDS" gene complement(3218565..3219497) /gene="hprK" /locus_tag="BSU_35000" /old_locus_tag="BSU35000" /label="hprK gene" promotor_-10 complement(3219539..3219558) /Source="Nicolas_upshift_promotors" /id="U2741" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.518481518481518" /psig="0.998001998001998" /xcortree=2677 /SigmaFactorBS="ggtgttttccccccttttataaaatcTGTTTTaggttcaagc ccgaaAGTGATAAAATGAAAGTATTgtgagcaagctcggggcagcccggaacaggagg a" /listShort="hprK, lgt, yvoD, ppaX, yvoF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3219545) /Source="Nicolas_upshifts" /id="U2741" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.518481518481518" /psig="0.998001998001998" /xcortree=2677 /SigmaFactorBS="ggtgttttccccccttttataaaatcTGTTTTaggttcaagc ccgaaAGTGATAAAATGAAAGTATTgtgagcaagctcggggcagcccggaacaggagg a" /listShort="hprK, lgt, yvoD, ppaX, yvoF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3219574..3219579) /Source="Nicolas_upshift_promotors" /id="U2741" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.518481518481518" /psig="0.998001998001998" /xcortree=2677 /SigmaFactorBS="ggtgttttccccccttttataaaatcTGTTTTaggttcaagc ccgaaAGTGATAAAATGAAAGTATTgtgagcaagctcggggcagcccggaacaggagg a" /listShort="hprK, lgt, yvoD, ppaX, yvoF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3219614..3219621 /Source="Nicolas_upshift_promotors" /id="U2742" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.664335664335664" /psig="0.997002997002997" /xcortree=2396 /SigmaFactorBS="taaaacagattttataaaaggggggaaaacacctcagctggT CTAGATCactagtctgaaaaaGAGTAAAATAAAGGTATTcaaattccagaaaggcgga t" /listShort="nagA, nagBA, yvoA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3219633 /Source="Nicolas_upshifts" /id="U2742" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.664335664335664" /psig="0.997002997002997" /xcortree=2396 /SigmaFactorBS="taaaacagattttataaaaggggggaaaacacctcagctggT CTAGATCactagtctgaaaaaGAGTAAAATAAAGGTATTcaaattccagaaaggcgga t" /listShort="nagA, nagBA, yvoA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3219636..3219653 /Source="Nicolas_upshift_promotors" /id="U2742" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.664335664335664" /psig="0.997002997002997" /xcortree=2396 /SigmaFactorBS="taaaacagattttataaaaggggggaaaacacctcagctggT CTAGATCactagtctgaaaaaGAGTAAAATAAAGGTATTcaaattccagaaaggcgga t" /listShort="nagA, nagBA, yvoA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3219679..3220869 /gene="nagA" /locus_tag="BSU_35010" /old_locus_tag="BSU35010" /EC_number="3.5.1.25" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:6774970, 14557261, 21602348" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6774970, 14557261, 21602348; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylglucosamine-6-phosphate deacetylase" /protein_id="NP_391381.1" /db_xref="EnsemblGenomes-Gn:BSU35010" /db_xref="EnsemblGenomes-Tr:CAB15506" /db_xref="GOA:O34450" /db_xref="InterPro:IPR003764" /db_xref="InterPro:IPR006680" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR032466" /db_xref="PDB:2VHL" /db_xref="SubtiList:BG12630" /db_xref="UniProtKB/Swiss-Prot:O34450" /translation="MAESLLIKDIAIVTENEVIKNGYVGINDGKISTVSTERPKEPYS KEIQAPADSVLLPGMIDIHIHGGYGADTMDASFSTLDIMSSRLPEEGTTSFLATTITQ EHGNISQALVNAREWKAAEESSLLGAELLGIHLEGPFVSPKRAGAQPKEWIRPSDVEL FKKWQQEAGGLIKIVTLAPEEDQHFELIRHLKDESIIASMGHTDADSALLSDAAKAGA SHMTHLYNAMSPFHHREPGVIGTALAHDGFVTELIADGIHSHPLAAKLAFLAKGSSKL ILITDSMRAKGLKDGVYEFGGQSVTVRGRTALLSDGTLAGSILKMNEGARHMREFTNC SWTDIANITSENAAKQLGIFDRKGSVTVGKDADLVIVSSDCEVILTICRGNIAFISKE ADQI*" /label="nagA CDS" gene 3219679..3220869 /gene="nagA" /locus_tag="BSU_35010" /old_locus_tag="BSU35010" /label="nagA gene" promotor_-35 3220667..3220673 /Source="Nicolas_upshift_promotors" /id="U2743" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=172 /SigmaFactorBS="cgatcctcaaaatgaacgaaggcgcacggcatatgcgtgAGT TTACaaattgctcttggacGGATATAGCTAATATAACTtctgaaaacgcggccaaaca g" /listShort="nagBA, yvoA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3220688 /Source="Nicolas_upshifts" /id="U2743" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=172 /SigmaFactorBS="cgatcctcaaaatgaacgaaggcgcacggcatatgcgtgAGT TTACaaattgctcttggacGGATATAGCTAATATAACTtctgaaaacgcggccaaaca g" /listShort="nagBA, yvoA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3220689..3220707 /Source="Nicolas_upshift_promotors" /id="U2743" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=172 /SigmaFactorBS="cgatcctcaaaatgaacgaaggcgcacggcatatgcgtgAGT TTACaaattgctcttggacGGATATAGCTAATATAACTtctgaaaacgcggccaaaca g" /listShort="nagBA, yvoA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3220866..3221594 /gene="nagBA" /locus_tag="BSU_35020" /old_locus_tag="BSU35020" /EC_number="3.5.99.6" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15755726, 18436239" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15755726, 18436239; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucosamine-6-phosphate isomerase" /protein_id="NP_391382.1" /db_xref="EnsemblGenomes-Gn:BSU35020" /db_xref="EnsemblGenomes-Tr:CAB15507" /db_xref="GOA:O35000" /db_xref="InterPro:IPR004547" /db_xref="InterPro:IPR006148" /db_xref="InterPro:IPR018321" /db_xref="PDB:2BKV" /db_xref="PDB:2BKX" /db_xref="SubtiList:BG12631" /db_xref="UniProtKB/Swiss-Prot:O35000" /translation="MKVMECQTYEELSQIAARITADTIKEKPDAVLGLATGGTPEGTY RQLIRLHQTENLSFQNITTVNLDEYAGLSSDDPNSYHFYMNDRFFQHIDSKPSRHFIP NGNADDLEAECRRYEQLVDSLGDTDIQLLGIGRNGHIGFNEPGTSFKSRTHVVTLNEQ TRQANARYFPSIDSVPKKALTMGIQTILSSKRILLLISGKSKAEAVRKLLEGNISEDF PASALHLHSDVTVLIDREAASLRP*" /label="nagBA CDS" gene 3220866..3221594 /gene="nagBA" /locus_tag="BSU_35020" /old_locus_tag="BSU35020" /label="nagBA gene" CDS 3221612..3222343 /gene="nagR" /locus_tag="BSU_35030" /old_locus_tag="BSU35030" /experiment="publication(s) with functional evidences, PMID:16207374, 20047956, 21602348, 23667565, 24673833, 26162881" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16207374, 20047956, 21602348, 23667565, 24673833, 26162881; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (GntR family)" /protein_id="NP_391383.1" /db_xref="EnsemblGenomes-Gn:BSU35030" /db_xref="EnsemblGenomes-Tr:CAB15508" /db_xref="GOA:O34817" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR011663" /db_xref="InterPro:IPR028978" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2WV0" /db_xref="PDB:4U0V" /db_xref="PDB:4U0W" /db_xref="PDB:4U0Y" /db_xref="PDB:4WWC" /db_xref="SubtiList:BG14124" /db_xref="UniProtKB/Swiss-Prot:O34817" /translation="MNINKQSPIPIYYQIMEQLKTQIKNGELQPDMPLPSEREYAEQF GISRMTVRQALSNLVNEGLLYRLKGRGTFVSKPKMEQALQGLTSFTEDMKSRGMTPGS RLIDYQLIDSTEELAAILGCGHPSSIHKITRVRLANDIPMAIESSHIPFELAGELNES HFQSSIYDHIERYNSIPISRAKQELEPSAATTEEANILGIQKGAPVLLIKRTTYLQNG TAFEHAKSVYRGDRYTFVHYMDRLS*" /label="nagR CDS" gene 3221612..3222343 /gene="nagR" /locus_tag="BSU_35030" /old_locus_tag="BSU35030" /label="nagR gene" CDS complement(3222363..3226232) /gene="yvnB" /locus_tag="BSU_35040" /old_locus_tag="BSU35040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 27542896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative exported hydrolase" /protein_id="NP_391384.1" /db_xref="EnsemblGenomes-Gn:BSU35040" /db_xref="EnsemblGenomes-Tr:CAB15509" /db_xref="GOA:O34986" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR011401" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR029052" /db_xref="InterPro:IPR036415" /db_xref="SubtiList:BG14123" /db_xref="UniProtKB/Swiss-Prot:O34986" /translation="MRKYTVIASILLSFLSVLSGGHHESKAFPVVQQELFQTPHYIPL LENPPQIDVKAEMRSNLMIEAQVRDNSYQAFSAFLFYKQSNELGYKMVPMDPTPGAVR KFLAQIPKRLIWNSELEYYIVMSNGKQRVESETKKLKLEGYQADLAHIPELLITELAV DTKNIGRADGYEFIEIFNTTDRTIDFKDYHIRYRYPKEGPDSDLIWRPDERILIPSGE TFVVWLKPAGHPELTSADFNRYYQTQLKEGKNLAVIDETEGMANTRPRAVVISTNTGK DISVAHYRKHALRRLSSVLYKYPLNGTAELLNISIGEKNPSPGTVLQAQVPDQKRKIK LDKEKPVIEDLTDRKPVRPAESIELRADIRDRSLVKTVAFYYRTDENKPFKRILAEKD RNDNLFHYIVYSPELIGKDQLEYYVAAGDGINEARTPVKMIDIKQTSKAHGLRMNIEN RDTLSGTQFLKATTEGRADSIKLWIDGKKQVTEPAMEKEVYFAFDTRKTNLYFKNAVT MEGKVLKVFDDTTNKYRTYSVPLPETLLRKGKQLQRITIRSGSKVSPFDTAENRDDFL VKNARLVLSDGTVIRDQRVSPEKELFIGDNQRSNKSWQFQFNLPDGLFTSQLLEWDTS KLSEGAHHIQASDGKENVSLVVRVDNSGPHIEPNITEGQTYKGNLILQADMYDKWSRI EEAEASLDGESITLPYHTSSSDLLPGKHSLKVTATDLAGNKTVIERIFKTEREHPDQP EVIDSEADTHKAKLSVRVKDPTNDAMDVGFYRGFQYTARNHVKIFKHASLTEPPKSFV PERETPFTNKELERVSAADGKTVSTENKELFPYHRFEVTVDPSIDENDLAESVWKGSS LPGRKVTMYAWNYRTNEWQPVDSFVAKDDKPFTLKASVIAADFVRESKMNVIVQDEIP PAKDMYTFVWMSDTQYYAESYPHIFDKQTEWIKDNQKQLNIKYVFHTGDIVDDSADIR QWKNADRSMSVLDKSGIPYGVLAGNHDVGHKDGSYRAFGKYFGSDRFDKKFHYGGSYK NNRGHYDLISSNGNDYIMLYMGWGITDEDIAWMNQVLKKHPDRMAILAFHEYLLVSGN RSPIGEKIFKEIVKPNPNVVMVLSGHYHSAMRKTDELDDDGDGKPDRLVHQMLADYQG GPEGGQGYLRLLQFDQANDMVHVSTYSPYVKDKNYYDTDTYGNKDEFSLSLDLKPRIK KVETDYFECNVYTNEELGKREQVKSGDTAEFRWDHLEPQSVYYWYIIVEDSFNGKTKS PIWKFKTKKETYRPAPDQFDFRHVSNP*" /label="yvnB CDS" gene complement(3222363..3226232) /gene="yvnB" /locus_tag="BSU_35040" /old_locus_tag="BSU35040" /label="yvnB gene" downshifts complement(3222485) /Source="Nicolas_upshifts" /id="D1811" /incds=1 /nref=19 /ntot=109 /MaxReadThrough="1.28942" /MaxDrop="4.39575" /score="28.0438848" /energy="-16.5" /TU="NA" /idTUdmin="U2744" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3226252..3226263) /Source="Nicolas_upshift_promotors" /id="U2744" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=878 /SigmaFactorBS="cagacgtttttttgttctttatgcacaaaaatgaaCTCATAA gcttccctgttcagACGCAAAATACAtgaaaagggaggtgctttgatgaggaaataca c" /listShort="yvnB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3226259) /Source="Nicolas_upshifts" /id="U2744" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=878 /SigmaFactorBS="cagacgtttttttgttctttatgcacaaaaatgaaCTCATAA gcttccctgttcagACGCAAAATACAtgaaaagggaggtgctttgatgaggaaataca c" /listShort="yvnB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3226278..3226284) /Source="Nicolas_upshift_promotors" /id="U2744" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=878 /SigmaFactorBS="cagacgtttttttgttctttatgcacaaaaatgaaCTCATAA gcttccctgttcagACGCAAAATACAtgaaaagggaggtgctttgatgaggaaataca c" /listShort="yvnB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3226322..3226328 /Source="Nicolas_upshift_promotors" /id="U2745" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig=1 /xcortree=2922 /SigmaFactorBS="catttttgtgcataaagaacaaaaaaacgtctgtcTCTTGAA aattccactattaCCCAGTAAACTAAGGATAGTtaaccagttaacaattaaatcagag a" /listShort="yvnA, S1334, S1335" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3226342..3226361 /Source="Nicolas_upshift_promotors" /id="U2745" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig=1 /xcortree=2922 /SigmaFactorBS="catttttgtgcataaagaacaaaaaaacgtctgtcTCTTGAA aattccactattaCCCAGTAAACTAAGGATAGTtaaccagttaacaattaaatcagag a" /listShort="yvnA, S1334, S1335" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3226347 /Source="Nicolas_upshifts" /id="U2745" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig=1 /xcortree=2922 /SigmaFactorBS="catttttgtgcataaagaacaaaaaaacgtctgtcTCTTGAA aattccactattaCCCAGTAAACTAAGGATAGTtaaccagttaacaattaaatcagag a" /listShort="yvnA, S1334, S1335" /GFF_Attribute="listLong" /label="upshifts" CDS 3226397..3226870 /gene="yvnA" /locus_tag="BSU_35050" /old_locus_tag="BSU35050" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_391385.1" /db_xref="EnsemblGenomes-Gn:BSU35050" /db_xref="EnsemblGenomes-Tr:CAB15510" /db_xref="GOA:O34692" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG14122" /db_xref="UniProtKB/Swiss-Prot:O34692" /translation="MDNSIHDELFQAIQQFALKRDKRVWQKVQIPSIGISSQHHDHLK KDWTLTQLHIVSCIHTSQNVNNSFLASRLHISKAAVSKAVHALLKHNIITVTKKPGNK KEIFYTLTDSGRKLAALHEQLHEKAKEQYKQLFNEFSIDDLKTVTAFFNLWIKYM*" /label="yvnA CDS" gene 3226397..3226870 /gene="yvnA" /locus_tag="BSU_35050" /old_locus_tag="BSU35050" /label="yvnA gene" S_feature 3226871..3226978 /Source="Nicolas_S_feature" /locus_tag="new_3602548_3602655" /HighExp="T5.0H, T4.0H, T3.30H, T3.0H, T2.30H, M9-stat, T2.0H, T1.30H, T1.0H, BC" /AntisenseName="cypX" /AntisenseCor="-1.1473096183385199E-3" /AntisenseRegPval=0 /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1334" CDS complement(3226911..3228128) /gene="cypX" /locus_tag="BSU_35060" /old_locus_tag="BSU35060" /EC_number="1.14.-.-" /function="16.5: Explore" /function="16.14: Store" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:4204912, 20690619, 27542896" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4204912, 20690619, 27542896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cyclo-L-leucyl-L-leucyl dipeptide oxidase, pulcheriminic synthase" /protein_id="NP_391386.1" /db_xref="EnsemblGenomes-Gn:BSU35060" /db_xref="EnsemblGenomes-Tr:CAB15511" /db_xref="GOA:O34926" /db_xref="InterPro:IPR001128" /db_xref="InterPro:IPR002397" /db_xref="InterPro:IPR017972" /db_xref="InterPro:IPR030904" /db_xref="InterPro:IPR036396" /db_xref="PDB:3NC3" /db_xref="PDB:3NC5" /db_xref="PDB:3NC6" /db_xref="PDB:3NC7" /db_xref="SubtiList:BG12580" /db_xref="UniProtKB/Swiss-Prot:O34926" /translation="MSQSIKLFSVLSDQFQNNPYAYFSQLREEDPVHYEESIDSYFIS RYHDVRYILQHPDIFTTKSLVERAEPVMRGPVLAQMHGKEHSAKRRIVVRSFIGDALD HLSPLIKQNAENLLAPYLERGKSDLVNDFGKTFAVCVTMDMLGLDKRDHEKISEWHSG VADFITSISQSPEARAHSLWCSEQLSQYLMPVIKERRVNPGSDLISILCTSEYEGMAL SDKDILALILNVLLAATEPADKTLALMIYHLLNNPEQMNDVLADRSLVPRAIAETLRY KPPVQLIPRQLSQDTVVGGMEIKKDTIVFCMIGAANRDPEAFEQPDVFNIHREDLGIK SAFSGAARHLAFGSGIHNCVGAAFAKNEIEIVANIVLDKMRNIRLEEDFCYAESGLYT RGPVSLLVAFDGA*" /label="cypX CDS" gene complement(3226911..3228128) /gene="cypX" /locus_tag="BSU_35060" /old_locus_tag="BSU35060" /label="cypX gene" downshifts complement(3226924) /Source="Nicolas_upshifts" /id="D1812" /incds=0 /nref=11 /ntot=50 /MaxReadThrough="2.27112" /MaxDrop="6.67384" /score="-0.264310319" /energy="-11.6" /TU="NA" /idTUdmin="U2747" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 3226950..3226955 /Source="Nicolas_upshift_promotors" /id="U2746" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.437562437562438" /psig="0.437562437562438" /xcortree=409 /SigmaFactorBS="gtcaaacgcaacgagaagtgaaacaggtccGCGTGTatacag accggactCAGCATAACAAAaatcttcctctaatctgatattccgcatcttatccagc a" /listShort="S1335" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3226970..3226981 /Source="Nicolas_upshift_promotors" /id="U2746" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.437562437562438" /psig="0.437562437562438" /xcortree=409 /SigmaFactorBS="gtcaaacgcaacgagaagtgaaacaggtccGCGTGTatacag accggactCAGCATAACAAAaatcttcctctaatctgatattccgcatcttatccagc a" /listShort="S1335" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3226980..3227265 /Source="Nicolas_S_feature" /locus_tag="new_3602657_3602942" /HighExp="BC, Sw, Lbstat, T5.0H, M9-stat, T4.0H, T3.30H, B60, T1.30H, T0.30H" /AntisenseName="cypX" /AntisenseCor="-4.04991056466339E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.438, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1335" upshifts 3226980 /Source="Nicolas_upshifts" /id="U2746" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.437562437562438" /psig="0.437562437562438" /xcortree=409 /SigmaFactorBS="gtcaaacgcaacgagaagtgaaacaggtccGCGTGTatacag accggactCAGCATAACAAAaatcttcctctaatctgatattccgcatcttatccagc a" /listShort="S1335" /GFF_Attribute="listLong" /label="upshifts" downshifts 3227222 /Source="Nicolas_upshifts" /id="D1813" /incds=1 /nref=9 /ntot=165 /MaxReadThrough="3.27492" /MaxDrop="3.99509" /score="54.0406126" /energy="-11.4" /TU="U2745,U2746" /idTUdmin="U2746" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" CDS complement(3228144..3228890) /gene="pchC" /locus_tag="BSU_35070" /old_locus_tag="BSU35070" /EC_number="6.-.-.-" /function="16.14: Store" /function="16.1: Circulate" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:4204912, 19430487, 27542896" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4204912, 19430487, 27542896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cyclodipeptide synthase (tRNA-dependent), pulcherimminic acid precursor" /protein_id="NP_391387.1" /db_xref="EnsemblGenomes-Gn:BSU35070" /db_xref="EnsemblGenomes-Tr:CAB15512" /db_xref="GOA:O34351" /db_xref="InterPro:IPR030903" /db_xref="SubtiList:BG14121" /db_xref="UniProtKB/Swiss-Prot:O34351" /translation="MTGMVTERRSVHFIAEALTENCREIFERRRHVLVGISPFNSRFS EDYIYRLIGWAKAQFKSVSVLLAGHEAANLLEALGTPRGKAERKVRKEVSRNRRFAER ALVAHGGDPKAIHTFSDFIDNKAYQLLRQEVEHAFFEQPHFRHACLDMSREAIIGRAR GVSLMMEEVSEDMLNLAVEYVIAELPFFIGAPDILEVEETLLAYHRPWKLGEKISNHE FSICMRPNQGYLIVQEMAQMLSEKRITSEG*" /label="pchC CDS" gene complement(3228144..3228890) /gene="pchC" /locus_tag="BSU_35070" /old_locus_tag="BSU35070" /label="pchC gene" S_feature complement(3228891..3229077) /Source="Nicolas_S_feature" /locus_tag="new_3604568_3604754_c" /HighExp="LBGstat, T1.30H, T2.0H, T2.30H, T3.0H, T1.0H, B36, BT, T3.30H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1336" promotor_-10 complement(3229063..3229082) /Source="Nicolas_upshift_promotors" /id="U2747" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.771228771228771" /psig=1 /xcortree=1627 /SigmaFactorBS="tacatttattttcaaatatttgggcacagatcatATTGACGT ttggaaggaaaagGGATAAAATGACTAATGTTTactagtaaacatttatcatgatatg g" /listShort="S1336, yvmC, cypX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3229077) /Source="Nicolas_upshifts" /id="U2747" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.771228771228771" /psig=1 /xcortree=1627 /SigmaFactorBS="tacatttattttcaaatatttgggcacagatcatATTGACGT ttggaaggaaaagGGATAAAATGACTAATGTTTactagtaaacatttatcatgatatg g" /listShort="S1336, yvmC, cypX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3229096..3229103) /Source="Nicolas_upshift_promotors" /id="U2747" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.771228771228771" /psig=1 /xcortree=1627 /SigmaFactorBS="tacatttattttcaaatatttgggcacagatcatATTGACGT ttggaaggaaaagGGATAAAATGACTAATGTTTactagtaaacatttatcatgatatg g" /listShort="S1336, yvmC, cypX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3229211..3229218 /Source="Nicolas_upshift_promotors" /id="U2748" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.571428571428571" /psig="0.998001998001998" /xcortree=1628 /SigmaFactorBS="tatcaacaaatagtctaaacaccaacAATTGACAacgaaaac aagaaaAGATAAAATAAAATTGTTCAccagtaaacgatttgttttattgtttcatcgt a" /listShort="S1337, yvmB, yvmA, S1339" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3229233..3229252 /Source="Nicolas_upshift_promotors" /id="U2748" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.571428571428571" /psig="0.998001998001998" /xcortree=1628 /SigmaFactorBS="tatcaacaaatagtctaaacaccaacAATTGACAacgaaaac aagaaaAGATAAAATAAAATTGTTCAccagtaaacgatttgttttattgtttcatcgt a" /listShort="S1337, yvmB, yvmA, S1339" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3229245 /Source="Nicolas_upshifts" /id="U2748" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.571428571428571" /psig="0.998001998001998" /xcortree=1628 /SigmaFactorBS="tatcaacaaatagtctaaacaccaacAATTGACAacgaaaac aagaaaAGATAAAATAAAATTGTTCAccagtaaacgatttgttttattgtttcatcgt a" /listShort="S1337, yvmB, yvmA, S1339" /GFF_Attribute="listLong" /label="upshifts" S_feature 3229246..3229315 /Source="Nicolas_S_feature" /locus_tag="new_3604923_3604992" /HighExp="LBGstat, T1.30H, T2.0H, T2.30H, T1.0H, T0.30H, B36, T3.0H, BT, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1337" CDS 3229316..3229825 /gene="pchR" /locus_tag="BSU_35080" /old_locus_tag="BSU35080" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:27542896" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 27542896; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator for pulcherriminic acid synthesis" /protein_id="NP_391388.1" /db_xref="EnsemblGenomes-Gn:BSU35080" /db_xref="EnsemblGenomes-Tr:CAB15513" /db_xref="GOA:P40762" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11018" /db_xref="UniProtKB/Swiss-Prot:P40762" /translation="MSDLTKQMIYDIYVRLLHLNEQKANTSLQQFFKEAAEEDVAEIP KNMTSIHVIDCIGQHEPINNAGIARKMNLSKANVTKISTKLIKEEFINSYQLTDNKKE VYFKLTRKGRRIFDLHEKLHKKKELAFYQFLDSFSQEEQKAVLKFLEQLTSTLEAEQT DGTPDKPVK*" /label="pchR CDS" gene 3229316..3229825 /gene="pchR" /locus_tag="BSU_35080" /old_locus_tag="BSU35080" /label="pchR gene" S_feature complement(3229721..3231059) /Source="Nicolas_S_feature" /locus_tag="new_3605398_3606736_c" /HighExp="T0.30H, T1.0H, T1.30H, T-0.40H, T0.0H, T2.0H, G135, T2.30H, T-1.10H, G180" /AntisenseName="yvmA" /AntisenseCor="0.2423954904641" /AntisenseRegPval="-4.2" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.993" /label="S1338" downshifts complement(3229762) /Source="Nicolas_upshifts" /id="D1814" /incds=1 /nref=1 /ntot=66 /MaxReadThrough="1.42525" /MaxDrop="2.72496" /score="14.1278884" /energy="-7.8" /TU="NA" /idTUdmin="U2749" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 3229846..3231057 /gene="pchE" /locus_tag="BSU_35090" /old_locus_tag="BSU35090" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 27542896" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 27542896; Product type t: transporter" /codon_start=1 /transl_table=11 /product="pulcherriminic acid efflux transporter" /protein_id="NP_391389.1" /db_xref="EnsemblGenomes-Gn:BSU35090" /db_xref="EnsemblGenomes-Tr:CAB15514" /db_xref="GOA:O34307" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG14120" /db_xref="UniProtKB/Swiss-Prot:O34307" /translation="MAHTKSKAVLILYTVCFSAFFASLSQNIYSPILPIIKESFHVST AMVNLSVSVFMIVTAIMQIILGAIIDFKGARIVLITGILATAAASIGCAVTTDFTLFL IFRMIQAAGSAALPLIAATTIGQLFTGNERGSAMGTYQMLLSVAPAIAPVLGGFIGGA AGYEGIFWILAAISIVLLVTNSITFPKDSPTESMQQAKGNVFAHYKSIFTNRTGNVIL TLSFVLFFIYFAVIVYLPILLTEHYHIDVGIAGLLYLPLALSTIAGTFLFKRIQAKIG LHTLFIGSNVIAACSIILFAVTHSVSLVLMALTLALFGISMGVIPPLYSTMITNEFEH NRGSAIGMFNFIRYTGMAAGPMVSAYLLTMMPSAMSFSLLGLGFAALSFCLLPPMFSP QKRTKQKKHHM*" /label="pchE CDS" gene 3229846..3231057 /gene="pchE" /locus_tag="BSU_35090" /old_locus_tag="BSU35090" /label="pchE gene" downshifts 3231055 /Source="Nicolas_upshifts" /id="D1815" /incds=0 /nref=33 /ntot=196 /MaxReadThrough="5.27186" /MaxDrop="4.73361" /score="54.0406126" /energy="-11.4" /TU="U2748" /idTUdmin="U2748" /TUdmin="-721" /isTUend="FALSE" /label="downshifts" CDS complement(3231085..3231444) /gene="yvlD" /locus_tag="BSU_35100" /old_locus_tag="BSU35100" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 26296725; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral phage holin-like membrane protein" /protein_id="NP_391390.1" /db_xref="EnsemblGenomes-Gn:BSU35100" /db_xref="EnsemblGenomes-Tr:CAB15515" /db_xref="GOA:O34648" /db_xref="InterPro:IPR007165" /db_xref="SubtiList:BG14119" /db_xref="UniProtKB/Swiss-Prot:O34648" /translation="MVKWAVSILVNALLLIVIDGYIDSIHISSIGAAIIASLILSILN VLIKPLLIIFTLPVTMVTLGLFLFVINAITLMMTASIMGDSFQIDGFGTAIWASVILS VFHLLIQKGILEPLRKK*" /label="yvlD CDS" gene complement(3231085..3231444) /gene="yvlD" /locus_tag="BSU_35100" /old_locus_tag="BSU35100" /label="yvlD gene" S_feature 3231100..3231816 /Source="Nicolas_S_feature" /locus_tag="new_3606777_3607493" /HighExp="LBGstat, S8, Gly, C30, G135, S7, C90, Sw, Fru, S6" /AntisenseName="yvlC" /AntisenseCor="0.178445666283919" /AntisenseRegPval="-2.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1339" downshifts complement(3231104) /Source="Nicolas_upshifts" /id="D1816" /incds=0 /nref=129 /ntot=265 /MaxReadThrough="4.63835" /MaxDrop="5.15146" /score="14.4434545" /energy="-9.6" /TU="U2749" /idTUdmin="U2751" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3231446..3231643) /gene="yvlC" /locus_tag="BSU_35110" /old_locus_tag="BSU35110" /function="16.3: Control" /function="16.12: Sense" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 23980836; Product type r : regulator" /codon_start=1 /transl_table=11 /product="membrane associated phage-like stress regulator,nisin resistance" /protein_id="NP_391391.1" /db_xref="EnsemblGenomes-Gn:BSU35110" /db_xref="EnsemblGenomes-Tr:CAB15516" /db_xref="GOA:O34719" /db_xref="InterPro:IPR007168" /db_xref="SubtiList:BG14118" /db_xref="UniProtKB/Swiss-Prot:O34719" /translation="MNKLYRSEKNKKIAGVIGGLAEYFNWDASLLRVITVILAIMTSV LPVLLIYIIWIFIVPSERDMK*" /label="yvlC CDS" gene complement(3231446..3231643) /gene="yvlC" /locus_tag="BSU_35110" /old_locus_tag="BSU35110" /label="yvlC gene" CDS complement(3231648..3232745) /gene="yvlB" /locus_tag="BSU_35120" /old_locus_tag="BSU35120" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 23980836" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function, stress-related" /protein_id="NP_391392.1" /db_xref="EnsemblGenomes-Gn:BSU35120" /db_xref="EnsemblGenomes-Tr:CAB15517" /db_xref="InterPro:IPR016599" /db_xref="InterPro:IPR025164" /db_xref="SubtiList:BG14117" /db_xref="UniProtKB/Swiss-Prot:O34628" /translation="MKQEKERILKLVEEGKLTAQEALTLIEKLDSDYKEKEEKITALS VHVHDEEEPFTTAKKESGKPSLGAKLFDWIDSAVKKVKEVDLDLNFGHAYDVQHIFQF KDTDFSSVELQIANGSVNIVPWEDDDIRAECQAKVYRADSQDAARHAFLQHIECEIKG NKFFIRTEKKTMKTNVTLYIPQKEYDKIRVKLFNGPVRGEHLHVKEFSAKTTNGVLSF SYLTAEKAIAETANGQIKLASHSCGTIEAETINGLIDLRGKSESIDVQSFNGNIAINV TESDCRSIYAKTTTGNVELAIPDDLAVKAELKSNLGTLSHELMDVEMLKEKNDTIQKE MMFTSNQAHDQNITVFSESLTGAIKLKYSQR*" /label="yvlB CDS" gene complement(3231648..3232745) /gene="yvlB" /locus_tag="BSU_35120" /old_locus_tag="BSU35120" /label="yvlB gene" CDS complement(3232770..3233096) /gene="yvlA" /locus_tag="BSU_35130" /old_locus_tag="BSU35130" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 23980836" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391393.1" /db_xref="EnsemblGenomes-Gn:BSU35130" /db_xref="EnsemblGenomes-Tr:CAB15518" /db_xref="GOA:O34322" /db_xref="SubtiList:BG14116" /db_xref="UniProtKB/Swiss-Prot:O34322" /translation="MNRNQAIIASLCYFSVFIAPIIVPIVAYFVVNEKETKRHAIRSL ISHIVPFVGWLFLFIALLGGAVAIDGDSLLPVFVIIGGAVIYFLVVIGIIIWNVIQGI KVLRAA*" /label="yvlA CDS" gene complement(3232770..3233096) /gene="yvlA" /locus_tag="BSU_35130" /old_locus_tag="BSU35130" /label="yvlA gene" promotor_-10 complement(3233149..3233164) /Source="Nicolas_upshift_promotors" /id="U2749" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1667 /SigmaFactorBS="ccaatttccgtaaatcggagcatgtctaaagaatgaattTGA AACCTGAagagattttaaACGTATAAATAAGTAAaacgtccctgatcttttgtcatgg a" /listShort="yvlA, yvlB, yvlC, yvlD, S1338" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3233164) /Source="Nicolas_upshifts" /id="U2749" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1667 /SigmaFactorBS="ccaatttccgtaaatcggagcatgtctaaagaatgaattTGA AACCTGAagagattttaaACGTATAAATAAGTAAaacgtccctgatcttttgtcatgg a" /listShort="yvlA, yvlB, yvlC, yvlD, S1338" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3233166..3233656) /Source="Nicolas_S_feature" /locus_tag="new_3608843_3609333_c" /HighExp="H2O2, G180, Paraq, G150, G135, dia15, Oxctl, Diami, Lbexp, LBGexp" /AntisenseName="yvkN" /AntisenseCor="0.37678416921083902" /AntisenseRegPval="-9.8000000000000007" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1340" promotor_-35 complement(3233176..3233185) /Source="Nicolas_upshift_promotors" /id="U2749" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1667 /SigmaFactorBS="ccaatttccgtaaatcggagcatgtctaaagaatgaattTGA AACCTGAagagattttaaACGTATAAATAAGTAAaacgtccctgatcttttgtcatgg a" /listShort="yvlA, yvlB, yvlC, yvlD, S1338" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3233244..3233247 /Source="Nicolas_upshift_promotors" /id="U2750" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.995004995004995" /xcortree=2993 /SigmaFactorBS="ttacggaaattggattttaaaaagttttagaaGTAGaatctt ccggctatACCGATTACAATATGTAAAAagcttacggcaaccaaggaggctggacaag c" /listShort="yvkN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3233262..3233281 /Source="Nicolas_upshift_promotors" /id="U2750" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.995004995004995" /xcortree=2993 /SigmaFactorBS="ttacggaaattggattttaaaaagttttagaaGTAGaatctt ccggctatACCGATTACAATATGTAAAAagcttacggcaaccaaggaggctggacaag c" /listShort="yvkN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3233272 /Source="Nicolas_upshifts" /id="U2750" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.995004995004995" /xcortree=2993 /SigmaFactorBS="ttacggaaattggattttaaaaagttttagaaGTAGaatctt ccggctatACCGATTACAATATGTAAAAagcttacggcaaccaaggaggctggacaag c" /listShort="yvkN" /GFF_Attribute="listLong" /label="upshifts" CDS 3233314..3233544 /gene="yvkN" /locus_tag="BSU_35140" /old_locus_tag="BSU35140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391394.1" /db_xref="EnsemblGenomes-Gn:BSU35140" /db_xref="EnsemblGenomes-Tr:CAB15519" /db_xref="SubtiList:BG14115" /db_xref="UniProtKB/Swiss-Prot:O34604" /translation="MEKDPSDYTVTQESVLKLIQEQKRMNREMITELEQIHGPFPISH DIQYIKVLLDSSNTHIVQDLMSVSKQLYKKTL*" /label="yvkN CDS" gene 3233314..3233544 /gene="yvkN" /locus_tag="BSU_35140" /old_locus_tag="BSU35140" /label="yvkN gene" promotor_-10 complement(3233647..3233666) /Source="Nicolas_upshift_promotors" /id="U2751" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.845154845154845" /psig="0.993006993006993" /xcortree=1844 /SigmaFactorBS="agttacagcttgccgacagagtccattaactGGATGtgccgg caggcttttTTTGTTACAATCATTTTGTGacagccagggaatcacttgttttttcaaa a" /listShort="S1340, yvlA, yvlB, yvlC, yvlD" /listLong="S1338" /label="promotor_-10" upshifts complement(3233657) /Source="Nicolas_upshifts" /id="U2751" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.845154845154845" /psig="0.993006993006993" /xcortree=1844 /SigmaFactorBS="agttacagcttgccgacagagtccattaactGGATGtgccgg caggcttttTTTGTTACAATCATTTTGTGacagccagggaatcacttgttttttcaaa a" /listShort="S1340, yvlA, yvlB, yvlC, yvlD" /listLong="S1338" /label="upshifts" promotor_-35 complement(3233682..3233686) /Source="Nicolas_upshift_promotors" /id="U2751" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.845154845154845" /psig="0.993006993006993" /xcortree=1844 /SigmaFactorBS="agttacagcttgccgacagagtccattaactGGATGtgccgg caggcttttTTTGTTACAATCATTTTGTGacagccagggaatcacttgttttttcaaa a" /listShort="S1340, yvlA, yvlB, yvlC, yvlD" /listLong="S1338" /label="promotor_-35" CDS complement(3233743..3234225) /gene="yvzB" /locus_tag="BSU_35150" /old_locus_tag="BSU35150" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16936039; Product type s: structure" /pseudo /codon_start=1 /transl_table=11 /product="putative flagellin" /db_xref="EnsemblGenomes-Gn:BSU35150" /db_xref="EnsemblGenomes-Tr:CAB15520" /db_xref="GOA:O34366" /db_xref="InterPro:IPR001029" /db_xref="PSEUDO:CAB15520.1" /db_xref="SubtiList:BG14158" /db_xref="UniProtKB/Swiss-Prot:O34366" /translation="MDALIEEVDGISNRTEFNGKKLLDGTETDGFTFQIGANAGQQLT VNIDSMSSTALGVNALNVTDFANTPFDTQLESIDTAINNVSNQRAKLGAVQNRLEHTI NNLGASSENLTAAESRIRDVDMAKEMSEFTKNNIPSQASQAMLAQANQQPQNVLQLLR *" /label="yvzB CDS" gene complement(3233743..3234225) /gene="yvzB" /locus_tag="BSU_35150" /old_locus_tag="BSU35150" /pseudo /label="yvzB gene" downshifts 3233751 /Source="Nicolas_upshifts" /id="D1817" /incds=0 /nref=13 /ntot=113 /MaxReadThrough="0.9814" /MaxDrop="4.76969" /score="2.6592903" /energy="-5.7" /TU="NA" /idTUdmin="U2750" /TUdmin=17 /isTUend="TRUE" /label="downshifts" downshifts complement(3233766) /Source="Nicolas_upshifts" /id="D1818" /incds=0 /nref=118 /ntot=206 /MaxReadThrough="2.62918" /MaxDrop="8.97968" /score="25.6132739" /energy="-19.8" /TU="NA" /idTUdmin="U2752" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(3233898) /Source="Nicolas_upshifts" /id="U2752" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96003996003996" /psig="0.011988011988012" /xcortree=15 /SigmaFactorBS="aaacttggtgcggtacaaaaccgtctagagcacacaatcaac aaccttgGTGCttcttctgaaaacctgacagctgctgagtcccgtatccgtgacgttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(3233906..3233909) /Source="Nicolas_upshift_promotors" /id="U2752" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96003996003996" /psig="0.011988011988012" /xcortree=15 /SigmaFactorBS="aaacttggtgcggtacaaaaccgtctagagcacacaatcaac aaccttgGTGCttcttctgaaaacctgacagctgctgagtcccgtatccgtgacgttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(3233986..3233990) /Source="Nicolas_upshift_promotors" /id="U2753" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.831168831168831" /psig="0.154845154845155" /xcortree=16 /SigmaFactorBS="taatgtaacagattttgctaatactccttttgatacaCAACt tgaaagtattgataCTGCAatcaacaatgtctcaaaccaacgtgctaaacttggtgcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3233986) /Source="Nicolas_upshifts" /id="U2753" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.831168831168831" /psig="0.154845154845155" /xcortree=16 /SigmaFactorBS="taatgtaacagattttgctaatactccttttgatacaCAACt tgaaagtattgataCTGCAatcaacaatgtctcaaaccaacgtgctaaacttggtgcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3234006..3234009) /Source="Nicolas_upshift_promotors" /id="U2753" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.831168831168831" /psig="0.154845154845155" /xcortree=16 /SigmaFactorBS="taatgtaacagattttgctaatactccttttgatacaCAACt tgaaagtattgataCTGCAatcaacaatgtctcaaaccaacgtgctaaacttggtgcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3234226..3234359) /Source="Nicolas_S_feature" /locus_tag="new_3609903_3610036_c" /HighExp="H2O2, Sw, M40t45, M40t90, Diami, Salt, dia15, BC, G135, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1341" CDS complement(3234387..3237260) /gene="uvrA" /locus_tag="BSU_35160" /old_locus_tag="BSU35160" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11751826, 16267290, 16426634, 25713353, 27399782" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11751826, 16267290, 16426634, 25713353, 27399782; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="excinuclease ABC (subunit A)" /protein_id="NP_391396.1" /db_xref="EnsemblGenomes-Gn:BSU35160" /db_xref="EnsemblGenomes-Tr:CAB15533" /db_xref="GOA:O34863" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004602" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12697" /db_xref="UniProtKB/Swiss-Prot:O34863" /translation="MAMDRIEVKGARAHNLKNIDVTIPRDQLVVVTGLSGSGKSSLAF DTIYAEGQRRYVESLSAYARQFLGQMDKPDVDAIEGLSPAISIDQKTTSRNPRSTVGT VTEIYDYLRLLYARVGKPHCPEHGIEITSQTIEQMVDRILEYPERTKLQVLAPIVSGR KGAHVKVLEQIRKQGYVRVRIDGEMAELSDDIELEKNKKHSIEVVIDRIVVKEGVAAR LSDSLETALRLGEGRVMIDVIGEEELMFSEHHACPHCGFSIGELEPRLFSFNSPFGAC PTCDGLGMKLEVDADLVIPNQDLSLKENAVAPWTPISSQYYPQLLEAVCTHYGIDMDV PVKDLPKHQLDKVLYGSGDDLIYFRYENDFGQIREGEIQFEGVLRNIERRYKETGSDF IREQMEQYMSQKSCPTCKGYRLKKEALAVLIDGRHIGKITELSVADALAFFKDLTLSE KDMQIANLILREIVERLSFLDKVGLDYLTLSRAAGTLSGGEAQRIRLATQIGSRLSGV LYILDEPSIGLHQRDNDRLISALKNMRDLGNTLIVVEHDEDTMMAADYLIDIGPGAGI HGGQVISAGTPEEVMEDPNSLTGSYLSGKKFIPLPPERRKPDGRYIEIKGASENNLKK VNAKFPLGTFTAVTGVSGSGKSTLVNEILHKALAQKLHKAKAKPGSHKEIKGLDHLDK VIDIDQAPIGRTPRSNPATYTGVFDDIRDVFAQTNEAKVRGYKKGRFSFNVKGGRCEA CRGDGIIKIEMHFLPDVYVPCEVCHGKRYNRETLEVTYKGKSISDVLDMTVEDALSFF ENIPKIKRKLQTLYDVGLGYITLGQPATTLSGGEAQRVKLASELHKRSTGRTLYILDE PTTGLHVDDIARLLVVLQRLVDNGDTVLVIEHNLDIIKTADYIVDLGPEGGAGGGTIV ASGTPEEITEVEESYTGRYLKPVIERDKTRMKSLLKAKETATS*" /label="uvrA CDS" gene complement(3234387..3237260) /gene="uvrA" /locus_tag="BSU_35160" /old_locus_tag="BSU35160" /label="uvrA gene" downshifts complement(3234404) /Source="Nicolas_upshifts" /id="D1819" /incds=0 /nref=240 /ntot=268 /MaxReadThrough="4.46283" /MaxDrop="5.3695" /score="12.0157254" /energy="-18.6" /TU="U2754,U2756" /idTUdmin="U2755" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3237268..3239253) /gene="uvrB" /locus_tag="BSU_35170" /old_locus_tag="BSU35170" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11751826, 16267290, 16426634, 25713353, 27399782" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11751826, 16267290, 16426634, 25713353, 27399782; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="excinuclease ABC (subunit B)" /protein_id="NP_391397.1" /db_xref="EnsemblGenomes-Gn:BSU35170" /db_xref="EnsemblGenomes-Tr:CAB15534" /db_xref="GOA:P37954" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR001943" /db_xref="InterPro:IPR004807" /db_xref="InterPro:IPR006935" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR024759" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036876" /db_xref="PDB:2D7D" /db_xref="PDB:2NMV" /db_xref="PDB:3V4R" /db_xref="SubtiList:BG10502" /db_xref="UniProtKB/Swiss-Prot:P37954" /translation="MKDRFELVSKYQPQGDQPKAIEKLVKGIQEGKKHQTLLGATGTG KTFTVSNLIKEVNKPTLVIAHNKTLAGQLYSEFKEFFPNNAVEYFVSYYDYYQPEAYV PQTDTFIEKDASINDEIDKLRHSATSALFERRDVIIIASVSCIYGLGSPEEYREMVVS LRTEMEIERNELLRKLVDIQYARNDIDFQRGTFRVRGDVVEIFPASRDEHCVRVEFFG DEIERIREVDALTGEILGDRDHVAIFPASHFVTRAEKMEKAIQNIEKELEEQLKVMHE NGKLLEAQRLEQRTRYDLEMMREMGFCSGIENYSRHLTLRPPGSTPYTLLDYFPDDFM IVVDESHVTIPQVRGMFNGDQARKQVLVDHGFRLPSALDNRPLRFEEFEKHMHNIVYV SATPGPYEIEHTDEMVEQIIRPTGLLDPLIDVRPIEGQIDDLIGEIQARIERNERVLV TTLTKKMSEDLTDYLKEIGIKVNYLHSEIKTLERIEIIRDLRLGKYDVLVGINLLREG LDIPEVSLVAILDADKEGFLRSERSLIQTIGRAARNAEGRVIMYADKITKSMEIAINE TKRRREQQERFNEEHGITPKTINKEIRDVIRATVAAEDKAEYKTKAAPKLSKMTKKER QKVVEQMEHEMKEAAKALDFERAAELRDLLLELKAEG*" /label="uvrB CDS" gene complement(3237268..3239253) /gene="uvrB" /locus_tag="BSU_35170" /old_locus_tag="BSU35170" /label="uvrB gene" promotor_-10 complement(3239287..3239306) /Source="Nicolas_upshift_promotors" /id="U2754" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=2093 /SigmaFactorBS="aaataaaaaaccaccgaactttagttcgtattttTAGTGATT ttgctttccatTGTGTTACTATATCTATAGGaagatttcgttaaagaaacggaggctt a" /listShort="uvrB, uvrA, S1341, yvzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3239299) /Source="Nicolas_upshifts" /id="U2754" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=2093 /SigmaFactorBS="aaataaaaaaccaccgaactttagttcgtattttTAGTGATT ttgctttccatTGTGTTACTATATCTATAGGaagatttcgttaaagaaacggaggctt a" /listShort="uvrB, uvrA, S1341, yvzB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3239301..3239386) /Source="Nicolas_S_feature" /locus_tag="new_3614978_3615063_c" /HighExp="Gly, Sw, B60, BT, LoTm, Salt, Etha, M9-stat, B36, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1342" promotor_-35 complement(3239318..3239325) /Source="Nicolas_upshift_promotors" /id="U2754" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=2093 /SigmaFactorBS="aaataaaaaaccaccgaactttagttcgtattttTAGTGATT ttgctttccatTGTGTTACTATATCTATAGGaagatttcgttaaagaaacggaggctt a" /listShort="uvrB, uvrA, S1341, yvzB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3239431) /Source="Nicolas_upshifts" /id="D1820" /incds=0 /nref=4 /ntot=60 /MaxReadThrough="5.68784" /MaxDrop="3.17938" /score="11.285993" /energy="-12" /TU="U2755,U2756" /idTUdmin="U2755" /TUdmin="-5027" /isTUend="FALSE" /label="downshifts" CDS complement(3239439..3239669) /gene="csbA" /locus_tag="BSU_35180" /old_locus_tag="BSU35180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 1592822, 1744042; Product type m:membrane component" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_391398.1" /db_xref="EnsemblGenomes-Gn:BSU35180" /db_xref="EnsemblGenomes-Tr:CAB15535" /db_xref="GOA:P37953" /db_xref="InterPro:IPR019242" /db_xref="SubtiList:BG10501" /db_xref="UniProtKB/Swiss-Prot:P37953" /translation="MITKAVFALFFPFMLVVLFTRVTFNHYVAIALTAALLFASYLKG YTETYFIVGLDVVSLVAGGLYMAKKAAEKKEE*" /label="csbA CDS" gene complement(3239439..3239669) /gene="csbA" /locus_tag="BSU_35180" /old_locus_tag="BSU35180" /label="csbA gene" promotor_-10 complement(3239696..3239715) /Source="Nicolas_upshift_promotors" /id="U2755" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.61038961038961" /psig=1 /xcortree=598 /SigmaFactorBS="ggtatggtgtaagtagagggagcgaatgcaCGATTGTCcgat tcttcatttTTTACTATAATCAGATCAGAtgaagaatccctgaggagggtttttgttg a" /listShort="csbA, S1342, uvrB, uvrA" /listLong="S1341, yvzB" /label="promotor_-10" upshifts complement(3239706) /Source="Nicolas_upshifts" /id="U2755" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.61038961038961" /psig=1 /xcortree=598 /SigmaFactorBS="ggtatggtgtaagtagagggagcgaatgcaCGATTGTCcgat tcttcatttTTTACTATAATCAGATCAGAtgaagaatccctgaggagggtttttgttg a" /listShort="csbA, S1342, uvrB, uvrA" /listLong="S1341, yvzB" /label="upshifts" S_feature complement(3239708..3239772) /Source="Nicolas_S_feature" /locus_tag="new_3615385_3615449_c" /HighExp="Gly, M9-stat, B60, Sw, Etha, LoTm, BT, B36, T1.30H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1343" promotor_-35 complement(3239729..3239736) /Source="Nicolas_upshift_promotors" /id="U2755" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.61038961038961" /psig=1 /xcortree=598 /SigmaFactorBS="ggtatggtgtaagtagagggagcgaatgcaCGATTGTCcgat tcttcatttTTTACTATAATCAGATCAGAtgaagaatccctgaggagggtttttgttg a" /listShort="csbA, S1342, uvrB, uvrA" /listLong="S1341, yvzB" /label="promotor_-35" promotor_-10 complement(3239749..3239767) /Source="Nicolas_upshift_promotors" /id="U2756" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=196 /SigmaFactorBS="accatggaataagttttgaccggcaccaaaatgcaaatatgg TGATTGAttttggctgaaaagGGGTATGGTGTAAGTAGAGggagcgaatgcacgattg t" /listShort="S1343, csbA, S1342, uvrB, uvrA, S1341, yvzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3239770) /Source="Nicolas_upshifts" /id="U2756" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=196 /SigmaFactorBS="accatggaataagttttgaccggcaccaaaatgcaaatatgg TGATTGAttttggctgaaaagGGGTATGGTGTAAGTAGAGggagcgaatgcacgattg t" /listShort="S1343, csbA, S1342, uvrB, uvrA, S1341, yvzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3239782..3239788) /Source="Nicolas_upshift_promotors" /id="U2756" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=196 /SigmaFactorBS="accatggaataagttttgaccggcaccaaaatgcaaatatgg TGATTGAttttggctgaaaagGGGTATGGTGTAAGTAGAGggagcgaatgcacgattg t" /listShort="S1343, csbA, S1342, uvrB, uvrA, S1341, yvzB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3239838) /Source="Nicolas_upshifts" /id="D1821" /incds=0 /nref=1 /ntot=9 /MaxReadThrough="0.9693" /MaxDrop="4.37808" /score="-1.92287727" /energy="-4.2" /TU="NA" /idTUdmin="U2761" /TUdmin=4752 /isTUend="FALSE" /label="downshifts" promotor_no_box complement(3239864..3239964) /Source="Nicolas_upshift_promotors" /id="U2757" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.236763236763237" /psig="0.378621378621379" /xcortree=1470 /SigmaFactorBS="aatagttaagttggttatattatcctgaaaaatgcggccgta ctggtactgtatgcctattttcttttattctcggaatctggcggcggacttgatgatg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(3239904) /Source="Nicolas_upshifts" /id="U2757" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.236763236763237" /psig="0.378621378621379" /xcortree=1470 /SigmaFactorBS="aatagttaagttggttatattatcctgaaaaatgcggccgta ctggtactgtatgcctattttcttttattctcggaatctggcggcggacttgatgatg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3239986..3239993 /Source="Nicolas_upshift_promotors" /id="U2758" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig="0.999000999001" /xcortree=566 /SigmaFactorBS="tcattttatttaggactttctgCGTTTGACagcattttcctg aAAACCTACAATTAAATGATAgtgtttactatcattttttaaacacaggctccgcaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3240007..3240026 /Source="Nicolas_upshift_promotors" /id="U2758" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig="0.999000999001" /xcortree=566 /SigmaFactorBS="tcattttatttaggactttctgCGTTTGACagcattttcctg aAAACCTACAATTAAATGATAgtgtttactatcattttttaaacacaggctccgcaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3240024 /Source="Nicolas_upshifts" /id="U2758" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig="0.999000999001" /xcortree=566 /SigmaFactorBS="tcattttatttaggactttctgCGTTTGACagcattttcctg aAAACCTACAATTAAATGATAgtgtttactatcattttttaaacacaggctccgcaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 3240116..3242611 /gene="yvkC" /locus_tag="BSU_35190" /old_locus_tag="BSU35190" /EC_number="2.7.-.-" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 25012659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphotransferase" /protein_id="NP_391399.1" /db_xref="EnsemblGenomes-Gn:BSU35190" /db_xref="EnsemblGenomes-Tr:CAB15536" /db_xref="GOA:O34796" /db_xref="InterPro:IPR002192" /db_xref="InterPro:IPR008279" /db_xref="InterPro:IPR013815" /db_xref="SubtiList:BG14114" /db_xref="UniProtKB/Swiss-Prot:O34796" /translation="MYSVLFRQAEESSQLAGAKGMNLIKLTKHGLPVPDGFIIQTNAL ARFMEDNQLQETSENVEGGIISGTFSDELKDELTSSFYKLRESYRSVAVRSSSASEDL EGASFAGQYETYLNIKTEEEFLAKVKECWASFFSGRVSSYKKKMNNQIAEPLMGIVVQ GLIDSEMSGVIFSRNPVTHDDRELLISASYGLGEAVVSGNVTPDTFIVNKSSFEIQKE IGAKEIYMESAAEGIAEKETSEDMRSRFCLTDEQVIELAEITKKTEDLYGYPVDIEFG IADHQIYLLQARPITTIDQDKKAAEEKRSFMITDTDMNDFWLNMESNIEGPVSPLFSS FIVPALEYGLKKSMQKFPIGVVVDEVKLYRGHIYSKNQGGQQPPSEDCGKELFPILSE HMYDIINHTYLPFYRTLDQLAQTEHTAESALEAFQKLKAFYLTAYEEHFNIVFPQILL TNKLQAMYQDIQGESENAHFYEMLTGKMNKSLETDRCLWLFSVEVQENPNLLAIFENN KPEQLQEKLEQTDEGRHFLKNVHEFLQEYGWRSVKSHDLIEQIWVENPYFALANIQNY VRNGYHFDNEFQKTKEKREKLYNEFLESIEDPGLRTEFDRYYQWTLNSANIKDDHHFY IDAMLDAKARIFLLKIGELLAENGVIQDREDLWFLYDDEVEQALLHPVSLQEKAEKRR QIFHEYELAQAPAYLGTPTKEQLKAAEEIVGAVIEDEKNTENHIFGIAASSGIATGPV KIIRDANEFSQFAPGDVLVCKMTTPLWTSLFQDAKAIITDTGGILSHAAIIAREYGIP AVLGTRTATERLRDGDIITVDGSSGKITVVSRS*" /label="yvkC CDS" gene 3240116..3242611 /gene="yvkC" /locus_tag="BSU_35190" /old_locus_tag="BSU35190" /label="yvkC gene" misc_feature 3242626..3242630 /Source="Nicolas_upshift_promotors" /id="U2759" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.358641358641359" /psig="0.448551448551449" /xcortree=2520 /SigmaFactorBS="caaaatcacagttgtcagccggtcctgatgcgtccccctctt TCTTAtacaagcggggcgggtgtatacttgtcctgccagtatattcgtgaggtgaaac g" /listShort="yvkB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3242644 /Source="Nicolas_upshifts" /id="U2759" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.358641358641359" /psig="0.448551448551449" /xcortree=2520 /SigmaFactorBS="caaaatcacagttgtcagccggtcctgatgcgtccccctctt TCTTAtacaagcggggcgggtgtatacttgtcctgccagtatattcgtgaggtgaaac g" /listShort="yvkB" /GFF_Attribute="listLong" /label="upshifts" CDS 3242687..3243256 /gene="yvkB" /locus_tag="BSU_35200" /old_locus_tag="BSU35200" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (TetR/AcrR family)" /protein_id="NP_391400.1" /db_xref="EnsemblGenomes-Gn:BSU35200" /db_xref="EnsemblGenomes-Tr:CAB15537" /db_xref="GOA:O34643" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="SubtiList:BG14113" /db_xref="UniProtKB/Swiss-Prot:O34643" /translation="MRPTNKRILDAAMQLLVKKGYRATTTKEIAEKANVSEATIFRNF KNKQGLVEALLSQHSSNRGSILEQTEGDLYKDLLHIGTCLLEELEHRKDIIKISFREP AMFQDVINHVTEYPQSMKQLLVDYLKTMGEKGVIQTGNEAEHADVFMSIIFGYFIHRL HLGDRVISMPQEKMLEHSTALFVKGISAD*" /label="yvkB CDS" gene 3242687..3243256 /gene="yvkB" /locus_tag="BSU_35200" /old_locus_tag="BSU35200" /label="yvkB gene" CDS 3243287..3244621 /gene="yvkA" /locus_tag="BSU_35210" /old_locus_tag="BSU35210" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_391401.1" /db_xref="EnsemblGenomes-Gn:BSU35210" /db_xref="EnsemblGenomes-Tr:CAB15538" /db_xref="GOA:O34502" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG14112" /db_xref="UniProtKB/Swiss-Prot:O34502" /translation="MSSRKEWALIVSLLLGAILVPINSTMIAVALSSISHTYNESIAS ITWVVTVYLIVMAVTQPIAGKLGDMYGNKTMYLWGVGLFLIASLGCALSPSLLLLIVF RALQAVGGALLTPNSIAIIRHVVSEKRLPKVFGFFGLGAGLGAALGPFIGSILIDSFS WHSIFWVNIPFLAIALFTALTMFPQYKENKSDAPLDIIGSLLLAGSIVSIILLTKNEA PWGYTVYSVLILLFVPLFFRREKRTQHPIIDFALFKSSTFTNANLSVLLSNLMMYAVL LIMPLFMTNQFGLNTSNSGMALSVFSIFMSASNWVGAQLHHKWGAKKIIFLSFAMMAG ANLLFLLLSSSHSVLFLMLSLILGGLASGVGLTSMQVSSLATVDPGMSGVASGIFSTF RYFGSIISSALIGLISGYHTLFMILFAVSIIGVFVSLGIKSDETARIEKNSA*" /label="yvkA CDS" gene 3243287..3244621 /gene="yvkA" /locus_tag="BSU_35210" /old_locus_tag="BSU35210" /label="yvkA gene" downshifts 3244602 /Source="Nicolas_upshifts" /id="D1822" /incds=0 /nref=4 /ntot=118 /MaxReadThrough="0.94661" /MaxDrop="3.57731" /score="21.0606505" /energy="-28.8" /TU="NA" /idTUdmin="U2759" /TUdmin=1276 /isTUend="FALSE" /label="downshifts" CDS complement(3244669..3245862) /gene="minJ" /locus_tag="BSU_35220" /old_locus_tag="BSU35220" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15849754, 16030230, 16850406, 18976281, 19019154, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16030230, 16850406, 18976281, 19019154, 26735940; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="topological determinant of cell division" /protein_id="NP_391402.1" /db_xref="EnsemblGenomes-Gn:BSU35220" /db_xref="EnsemblGenomes-Tr:CAB15539" /db_xref="GOA:O34375" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR036034" /db_xref="SubtiList:BG14111" /db_xref="UniProtKB/Swiss-Prot:O34375" /translation="MSVQWGIELLKSAGLFFLHPLFWFFIIITLAFGYVRIKRERKTF HTRIADIYDDLKFTYTKGLIPGLLLSVILGGLGISIPLGLLAIIAVITAAAAFTLRAN WMSAAYIVSVSMLIGFGLQIYQAEPFLERFPQGFAVVWPAVAVFLGLLIITEGAVAYR SAHVRTSPALVVSSRGLPIGQQLANRVWLLPLFLLVPGNGLESHLSWWPVFTVPGGSF HFLWIPYFVGFGQRVQGSLPETSIRITAKRVCILGLAVAVLGAASLLWTPLAGAAVCT ALLGRIFLSIKQRVNDNAAPFYFSKRDQGLMVLGIIPNTPAEDLELKIGEIITKVNGI PVKNVSDFYEALQHNRAYVKLEIIGLNGEIRFDQRASYEGEHHELGILFVKDDREDEA VASGS*" /label="minJ CDS" gene complement(3244669..3245862) /gene="minJ" /locus_tag="BSU_35220" /old_locus_tag="BSU35220" /label="minJ gene" downshifts complement(3244678) /Source="Nicolas_upshifts" /id="D1823" /incds=0 /nref=3 /ntot=85 /MaxReadThrough="3.18641" /MaxDrop="3.13207" /score="21.4231982" /energy="-25.6" /TU="U2761" /idTUdmin="U2760" /TUdmin=66 /isTUend="FALSE" /label="downshifts" downshifts complement(3244743) /Source="Nicolas_upshifts" /id="D1824" /incds=1 /nref=94 /ntot=239 /MaxReadThrough="4.11808" /MaxDrop="4.31508" /score="21.4231982" /energy="-25.6" /TU="U2761" /idTUdmin="U2760" /TUdmin=1 /isTUend="TRUE" /label="downshifts" S_feature complement(3245863..3245940) /Source="Nicolas_S_feature" /locus_tag="new_3621540_3621617_c" /HighExp="LBGstat, Lbstat, M0t90, Cold, M/G, GM 10, GM 25, GM 15, GM 60, GM 45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD, SigGF" /TUshortPSig="0.945, 0.998, 0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S1344" downshifts complement(3245866) /Source="Nicolas_upshifts" /id="D1825" /incds=0 /nref=1 /ntot=13 /MaxReadThrough="6.36185" /MaxDrop="3.35962" /score="-9.46264764" /energy="-7.1" /TU="U2760,U2761,U2762" /idTUdmin="U2762" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" CDS complement(3245941..3246279) /gene="swrAAc" /locus_tag="BSU_35230" /old_locus_tag="BSU35230" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15066026, 16030230" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15066026, 16030230; Product type cp: cell process" /pseudo /codon_start=1 /transl_table=11 /product="swarming motility protein fragment; C-terminal part of swrAA" /db_xref="GOA:O32266" /db_xref="InterPro:IPR035388" /db_xref="PSEUDO:CAB15540.1" /db_xref="SubtiList:BG14160" /db_xref="UniProtKB/Swiss-Prot:O32266" /translation="MCVKKKYYELVEQLKDRTQDVTFSATKALSLLMLFSRYLVNYTN VESVNDINEECAKHYFNYLMKNHKRLGINLTDIKRSMHLISGLLDVDVNHYLKDFSLS NVTLWMTQER*" /label="swrAAc CDS" gene complement(3245941..3246279) /gene="swrAAc" /locus_tag="BSU_35230" /old_locus_tag="BSU35230" /pseudo /label="swrAAc gene" CDS complement(3246254..3246370) /gene="swrAAn" /locus_tag="BSU_35239" /old_locus_tag="BSU35239" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type cp: cell process" /pseudo /codon_start=1 /transl_table=11 /product="swarming motility protein; N-terminal part of swrAA" /db_xref="PSEUDO:CAX52697.1" /translation="MLVSTPVLLLILARAYLYKENGGSQLKRASIVREKKIL*" /label="swrAAn CDS" gene complement(3246254..3246370) /gene="swrAAn" /locus_tag="BSU_35239" /old_locus_tag="BSU35239" /pseudo /label="swrAAn gene" S_feature complement(3246371..3246460) /Source="Nicolas_S_feature" /locus_tag="new_3622048_3622137_c" /HighExp="LBGstat, M0t90, Cold, Lbstat, GM 25, Gly, nit, GM 15, GM 10, M/G" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD, SigGF" /TUshortPSig="0.945, 0.998, 0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S1345" promotor_-10 complement(3246442..3246460) /Source="Nicolas_upshift_promotors" /id="U2760" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.494505494505495" /psig="0.945054945054945" /xcortree=2762 /SigmaFactorBS="ttctaacgagttaatatgcatttaaaatgaaacttttgcaaG TTGCCtagtctttgtttaCTTCATACAATATAAGAAGgttctaaaaagaacagtaatc a" /listShort="S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3246460) /Source="Nicolas_upshifts" /id="U2760" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.494505494505495" /psig="0.945054945054945" /xcortree=2762 /SigmaFactorBS="ttctaacgagttaatatgcatttaaaatgaaacttttgcaaG TTGCCtagtctttgtttaCTTCATACAATATAAGAAGgttctaaaaagaacagtaatc a" /listShort="S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3246462..3246542) /Source="Nicolas_S_feature" /locus_tag="new_3622139_3622219_c" /HighExp="LBGstat, Lbstat, Cold, M0t90, GM 25, nit, Gly, M/G, MG 150, GM 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigGF" /TUshortPSig="0.998, 0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S1346" promotor_-35 complement(3246474..3246479) /Source="Nicolas_upshift_promotors" /id="U2760" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.494505494505495" /psig="0.945054945054945" /xcortree=2762 /SigmaFactorBS="ttctaacgagttaatatgcatttaaaatgaaacttttgcaaG TTGCCtagtctttgtttaCTTCATACAATATAAGAAGgttctaaaaagaacagtaatc a" /listShort="S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3246528..3246546) /Source="Nicolas_upshift_promotors" /id="U2761" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=2797 /SigmaFactorBS="ttgacaagaaattaaaaaaattttcacaaataaacATTTATA AaggactgttattaCCCGATATCAATATATGAGagagactttctaacgagttaatatg c" /listShort="S1346, S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3246542) /Source="Nicolas_upshifts" /id="U2761" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=2797 /SigmaFactorBS="ttgacaagaaattaaaaaaattttcacaaataaacATTTATA AaggactgttattaCCCGATATCAATATATGAGagagactttctaacgagttaatatg c" /listShort="S1346, S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3246560..3246567) /Source="Nicolas_upshift_promotors" /id="U2761" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=2797 /SigmaFactorBS="ttgacaagaaattaaaaaaattttcacaaataaacATTTATA AaggactgttattaCCCGATATCAATATATGAGagagactttctaacgagttaatatg c" /listShort="S1346, S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3246679..3248121) /gene="ctpB" /locus_tag="BSU_35240" /old_locus_tag="BSU35240" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14526016, 17557826, 27342562" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14526016, 17557826, 27342562; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="PDZ-containing carboxyl-terminal protease processing protease [Zn(II)]" /protein_id="NP_391404.1" /db_xref="EnsemblGenomes-Gn:BSU35240" /db_xref="EnsemblGenomes-Tr:CAB15541" /db_xref="GOA:O35002" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR002477" /db_xref="InterPro:IPR004447" /db_xref="InterPro:IPR005151" /db_xref="InterPro:IPR029045" /db_xref="InterPro:IPR036034" /db_xref="InterPro:IPR036365" /db_xref="InterPro:IPR036366" /db_xref="PDB:4C2C" /db_xref="PDB:4C2D" /db_xref="PDB:4C2E" /db_xref="PDB:4C2F" /db_xref="PDB:4C2G" /db_xref="PDB:4C2H" /db_xref="SubtiList:BG14110" /db_xref="UniProtKB/Swiss-Prot:O35002" /translation="MNQKIMAVIAAGSMLFGGAGVYAGINLLEMDKPQTAAVPATAQA DSERDKAMDKIEKAYELISNEYVEKVDREKLLEGAIQGMLSTLNDPYSVYMDKQTAKQ FSDSLDSSFEGIGAEVGMEDGKIIIVSPFKKSPAEKAGLKPNDEIISINGESMAGKDL NHAVLKIRGKKGSSVSMKIQRPGTKKQLSFRIKRAEIPLETVFASEKKVQGHSVGYIA ISTFSEHTAEDFAKALRELEKKEIEGLVIDVRGNPGGYLQSVEEILKHFVTKDQPYIQ IAERNGDKKRYFSTLTHKKAYPVNVITDKGSASASEILAGALKEAGHYDVVGDTSFGK GTVQQAVPMGDGSNIKLTLYKWLTPNGNWIHKKGIEPTIAIKQPDYFSAGPLQLKEPL KVDMNNEDVKHAQVLLKGLSFDPGREDGYFSKDMKKAVMAFQDQNKLNKTGVIDTRTA ETLNQQIEKKKSDEKNDLQLQTALKSLFVN*" /label="ctpB CDS" gene complement(3246679..3248121) /gene="ctpB" /locus_tag="BSU_35240" /old_locus_tag="BSU35240" /label="ctpB gene" downshifts complement(3246768) /Source="Nicolas_upshifts" /id="D1826" /incds=1 /nref=1 /ntot=30 /MaxReadThrough="3.56833" /MaxDrop="3.1636" /score="0.562448109" /energy="-11.6" /TU="U2762" /idTUdmin="U2762" /TUdmin="-1122" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3248167..3248178) /Source="Nicolas_upshift_promotors" /id="U2762" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1138 /SigmaFactorBS="cgggacggcttttcatttgccttctttttcttctatgatTAC ATGAaatctccatcctttACATATACTATCtctaggttttggtaaagacagtctggca t" /listShort="ctpB, S1346, S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3248178) /Source="Nicolas_upshifts" /id="U2762" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1138 /SigmaFactorBS="cgggacggcttttcatttgccttctttttcttctatgatTAC ATGAaatctccatcctttACATATACTATCtctaggttttggtaaagacagtctggca t" /listShort="ctpB, S1346, S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3248193..3248199) /Source="Nicolas_upshift_promotors" /id="U2762" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1138 /SigmaFactorBS="cgggacggcttttcatttgccttctttttcttctatgatTAC ATGAaatctccatcctttACATATACTATCtctaggttttggtaaagacagtctggca t" /listShort="ctpB, S1346, S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3248261..3249151) /gene="ftsX" /locus_tag="BSU_35250" /old_locus_tag="BSU35250" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16352817, 17071757, 17307852, 18573177, 23855774, 23869552" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16352817, 17071757, 17307852, 18573177, 23855774, 23869552; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="cell-division ABC transporter" /protein_id="NP_391405.1" /db_xref="EnsemblGenomes-Gn:BSU35250" /db_xref="EnsemblGenomes-Tr:CAB15542" /db_xref="GOA:O34876" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR004513" /db_xref="SubtiList:BG12591" /db_xref="UniProtKB/Swiss-Prot:O34876" /translation="MIKILGRHLRESFKSLGRNTWMTFASISAVTVTLILVGVFLVIM LNLNNMATNAEKQVEIKVLIDLTADQKAQDKLQNDIKELKGIQSVTFSSKEKELDQLV DSFGDSGKSLTMKDQENPLNDAFVVKTTDPHDTPNVAKKIEKMDHVYKVTYGKEEVSR LFKVVGVSRNIGIALIIGLVFTAMFLISNTIKITIFARRKEIEIMKLVGATNWFIRWP FFLEGLLLGVFGSVIPIALVLSTYQYVIGWVVPKVQGSFVSLLPYNPFVFQVSLVLIA IGAVIGVWGSLTSIRKFLRV*" /label="ftsX CDS" gene complement(3248261..3249151) /gene="ftsX" /locus_tag="BSU_35250" /old_locus_tag="BSU35250" /label="ftsX gene" downshifts complement(3248278) /Source="Nicolas_upshifts" /id="D1827" /incds=0 /nref=144 /ntot=253 /MaxReadThrough="3.3693" /MaxDrop="6.15417" /score="15.3496791" /energy="-14.6" /TU="U2763" /idTUdmin="U2763" /TUdmin="-102" /isTUend="FALSE" /label="downshifts" CDS complement(3249144..3249830) /gene="ftsE" /locus_tag="BSU_35260" /old_locus_tag="BSU35260" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16352817, 17071757, 17307852, 18573177, 22006326, 23855774, 27167971" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16352817, 17071757, 17307852, 18573177, 22006326, 23855774, 27167971; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell-division signal transducer (ATP-binding protein)" /protein_id="NP_391406.1" /db_xref="EnsemblGenomes-Gn:BSU35260" /db_xref="EnsemblGenomes-Tr:CAB15543" /db_xref="GOA:O34814" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005286" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12590" /db_xref="UniProtKB/Swiss-Prot:O34814" /translation="MIEMKEVYKAYPNGVKALNGISVTIHPGEFVYVVGPSGAGKSTF IKMIYREEKPTKGQILINHKDLATIKEKEIPFVRRKIGVVFQDFKLLPKLTVFENVAF ALEVIGEQPSVIKKRVLEVLDLVQLKHKARQFPDQLSGGEQQRVSIARSIVNNPDVVI ADEPTGNLDPDTSWEVMKTLEEINNRGTTVVMATHNKEIVNTMKKRVIAIEDGIIVRD ESRGEYGSYD*" /label="ftsE CDS" gene complement(3249144..3249830) /gene="ftsE" /locus_tag="BSU_35260" /old_locus_tag="BSU35260" /label="ftsE gene" S_feature complement(3249831..3249963) /Source="Nicolas_S_feature" /locus_tag="new_3625508_3625640_c" /HighExp="Cold, UNK1, MG-0.2, MG 15, MG-0.1, C30, MG 25, MG 10, M9-exp, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA" /TUlongPSig="0.999, 0.998" /label="S1347" promotor_-10 complement(3249953..3249972) /Source="Nicolas_upshift_promotors" /id="U2763" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.9000999000999" /psig=1 /xcortree=2532 /SigmaFactorBS="atgccttgacaatatgaatgaaaagaaactgtaATAGtatta tgtctaaatTTGACGTATAATGAAGTGTAttgaaaaagggaactttcagatttttcat c" /listShort="S1347, ftsE, ftsX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3249963) /Source="Nicolas_upshifts" /id="U2763" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.9000999000999" /psig=1 /xcortree=2532 /SigmaFactorBS="atgccttgacaatatgaatgaaaagaaactgtaATAGtatta tgtctaaatTTGACGTATAATGAAGTGTAttgaaaaagggaactttcagatttttcat c" /listShort="S1347, ftsE, ftsX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3249987..3249990) /Source="Nicolas_upshift_promotors" /id="U2763" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.9000999000999" /psig=1 /xcortree=2532 /SigmaFactorBS="atgccttgacaatatgaatgaaaagaaactgtaATAGtatta tgtctaaatTTGACGTATAATGAAGTGTAttgaaaaagggaactttcagatttttcat c" /listShort="S1347, ftsE, ftsX" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3250064..3250402) /gene="cccB" /locus_tag="BSU_35270" /old_locus_tag="BSU35270" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10473570, 19222757" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10473570, 19222757; Product type f: factor" /codon_start=1 /transl_table=11 /product="cytochrome c551" /protein_id="NP_391407.1" /db_xref="EnsemblGenomes-Gn:BSU35270" /db_xref="EnsemblGenomes-Tr:CAB15544" /db_xref="GOA:O34594" /db_xref="InterPro:IPR009056" /db_xref="InterPro:IPR012218" /db_xref="InterPro:IPR036909" /db_xref="SubtiList:BG12574" /db_xref="UniProtKB/Swiss-Prot:O34594" /translation="MKSKLSILMIGFALSVLLAACGSNDAKEEKTDTGSKTEATASEG EELYQQSCVGCHGKDLEGVSGPNLQEVGGKYDEHKIESIIKNGRGNMPKGLVDDNEAA VIAKWLSEKK*" /label="cccB CDS" gene complement(3250064..3250402) /gene="cccB" /locus_tag="BSU_35270" /old_locus_tag="BSU35270" /label="cccB gene" downshifts complement(3250065) /Source="Nicolas_upshifts" /id="D1828" /incds=0 /nref=192 /ntot=265 /MaxReadThrough="3.58546" /MaxDrop="6.88513" /score="18.0901387" /energy="-16.8" /TU="U2764" /idTUdmin="U2765" /TUdmin=3 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3250429..3250448) /Source="Nicolas_upshift_promotors" /id="U2764" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.56943056943057" /psig="0.999000999001" /xcortree=1617 /SigmaFactorBS="aattgtagcagacgcgagcgaggtgctgggcgaGGGTTTCAa acgcgcttaaacGAGGTTATAATATGGAAGAGatcgtaaaggagttgtgcttctcaac a" /listShort="cccB" /listLong="S1347, ftsE, ftsX" /label="promotor_-10" upshifts complement(3250442) /Source="Nicolas_upshifts" /id="U2764" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.56943056943057" /psig="0.999000999001" /xcortree=1617 /SigmaFactorBS="aattgtagcagacgcgagcgaggtgctgggcgaGGGTTTCAa acgcgcttaaacGAGGTTATAATATGGAAGAGatcgtaaaggagttgtgcttctcaac a" /listShort="cccB" /listLong="S1347, ftsE, ftsX" /label="upshifts" CDS complement(3250451..3251335) /gene="yvjA" /locus_tag="BSU_35280" /old_locus_tag="BSU35280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10473570, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391408.2" /db_xref="EnsemblGenomes-Gn:BSU35280" /db_xref="EnsemblGenomes-Tr:CAB15545" /db_xref="GOA:O34792" /db_xref="InterPro:IPR003740" /db_xref="InterPro:IPR019264" /db_xref="SubtiList:BG14109" /db_xref="UniProtKB/Swiss-Prot:O34792" /translation="MLSESIGRNGGYMMDVRNKTLWILRDYVYILIGAAITAVSFNVF LLPNKIAAGGVSGISTILQSYGFEAAYVQWIINIPLFIAGVILLGGKFGLKTLAGSVF LPLVVFLTRDIQPATHHELLAAIFGGVGIGIGIGIVYLGKGSTGGTALAAQIIHKYSG LSLGKCLAIIDGMIVVTAMIVFNIEQGLYAMLGVYVSSKTIDVVQVGFNRSKMALIIT KQEQAVKEAVLQKIDRGVTKISAVGGYTDDDRPILMCVVGQTEFTKLKQIVKQIDESA FVIVADASEVLGEGFKRA*" /label="yvjA CDS" gene complement(3250451..3251335) /gene="yvjA" /locus_tag="BSU_35280" /old_locus_tag="BSU35280" /label="yvjA gene" promotor_-35 complement(3250462..3250469) /Source="Nicolas_upshift_promotors" /id="U2764" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.56943056943057" /psig="0.999000999001" /xcortree=1617 /SigmaFactorBS="aattgtagcagacgcgagcgaggtgctgggcgaGGGTTTCAa acgcgcttaaacGAGGTTATAATATGGAAGAGatcgtaaaggagttgtgcttctcaac a" /listShort="cccB" /listLong="S1347, ftsE, ftsX" /label="promotor_-35" promotor_-10 complement(3251323..3251342) /Source="Nicolas_upshift_promotors" /id="U2765" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.975024975024975" /psig="0.998001998001998" /xcortree=2728 /SigmaFactorBS="ttcactgctgctttagcatattaccactgtatttgggtgtTA TTTACAtctaatcagggaagGATTAAAATGCTATCGGAGAgcattggaagaaacggag g" /listShort="yvjA, cccB" /listLong="S1347, ftsE, ftsX" /label="promotor_-10" upshifts complement(3251344) /Source="Nicolas_upshifts" /id="U2765" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.975024975024975" /psig="0.998001998001998" /xcortree=2728 /SigmaFactorBS="ttcactgctgctttagcatattaccactgtatttgggtgtTA TTTACAtctaatcagggaagGATTAAAATGCTATCGGAGAgcattggaagaaacggag g" /listShort="yvjA, cccB" /listLong="S1347, ftsE, ftsX" /label="upshifts" promotor_-35 complement(3251357..3251364) /Source="Nicolas_upshift_promotors" /id="U2765" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.975024975024975" /psig="0.998001998001998" /xcortree=2728 /SigmaFactorBS="ttcactgctgctttagcatattaccactgtatttgggtgtTA TTTACAtctaatcagggaagGATTAAAATGCTATCGGAGAgcattggaagaaacggag g" /listShort="yvjA, cccB" /listLong="S1347, ftsE, ftsX" /label="promotor_-35" CDS join(complement(3252492..3252563), complement(3251462..3252490)) /gene="prfB" /locus_tag="BSU_35290" /old_locus_tag="BSU35290" /experiment="publication(s) with functional evidences, PMID:1408743, 9696765, 9882663" /ribosomal_slippage /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1408743, 9696765, 9882663; Product type f: factor" /codon_start=1 /transl_table=11 /product="peptide chain release factor 2" /protein_id="NP_391409.1" /db_xref="EnsemblGenomes-Gn:BSU35290" /db_xref="EnsemblGenomes-Tr:CAB15546" /db_xref="GOA:P28367" /db_xref="InterPro:IPR000352" /db_xref="InterPro:IPR004374" /db_xref="InterPro:IPR005139" /db_xref="InterPro:IPR020853" /db_xref="SubtiList:BG10742" /db_xref="UniProtKB/Swiss-Prot:P28367" /translation="MELSEIRAELENMASRLADFRGSLDLESKEARIAELDEQMADPE FWNDQQKAQTVINEANGLKDYVNSYKKLNESHEELQMTHDLLKEEPDTDLQLELEKEL KSLTKEFNEFELQLLLSEPYDKNNAILELHPGAGGTESQDWGSMLLRMYTRWGERRGF KVETLDYLPGDEAGIKSVTLLIKGHNAYGYLKAEKGVHRLVRISPFDSSGRRHTSFVS CEVMPEFNDEIDIDIRTEDIKVDTYRASGAGGQHVNTTDSAVRITHLPTNVVVTCQTE RSQIKNRERAMKMLKAKLYQRRIEEQQAELDEIRGEQKEIGWGSQIRSYVFHPYSMVK DHRTNTEMGNVQAVMDGDIDTFIDAYLRSKLS*" /label="prfB CDS" gene complement(3251462..3252563) /gene="prfB" /locus_tag="BSU_35290" /old_locus_tag="BSU35290" /label="prfB gene" downshifts complement(3251478) /Source="Nicolas_upshifts" /id="D1829" /incds=0 /nref=193 /ntot=257 /MaxReadThrough="2.78016" /MaxDrop="6.41678" /score="27.1588259" /energy="-9.8" /TU="NA" /idTUdmin="U2766" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" S_feature complement(3252564..3252632) /Source="Nicolas_S_feature" /locus_tag="new_3628241_3628309_c" /HighExp="Etha, Sw, Cold, BC, G150, BI, dia15, Mt0, LBGtran, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH, SigEF, SigD" /TUshortPSig="0.994, 0.997, 1, 1" /TUlongSig="SigA, SigD" /TUlongPSig="0.999, 1" /label="S1348" CDS complement(3252633..3255158) /gene="secA" /locus_tag="BSU_35300" /old_locus_tag="BSU35300" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9880811, 10074074, 10481054, 10559168, 10713435, 11021932, 12682299, 14621992, 16243836, 18923516, 23167435, 24592260, 26607006, 27336478" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9880811, 10074074, 10481054, 10559168, 10713435, 11021932, 12682299, 14621992, 16243836, 18923516, 23167435, 24592260, 26607006, 27336478; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="translocase binding subunit (ATPase)" /protein_id="NP_391410.1" /db_xref="EnsemblGenomes-Gn:BSU35300" /db_xref="EnsemblGenomes-Tr:CAB15547" /db_xref="GOA:P28366" /db_xref="InterPro:IPR000185" /db_xref="InterPro:IPR004027" /db_xref="InterPro:IPR011115" /db_xref="InterPro:IPR011116" /db_xref="InterPro:IPR011130" /db_xref="InterPro:IPR014018" /db_xref="InterPro:IPR020937" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036266" /db_xref="InterPro:IPR036670" /db_xref="PDB:1M6N" /db_xref="PDB:1M74" /db_xref="PDB:1TF2" /db_xref="PDB:1TF5" /db_xref="PDB:2IBM" /db_xref="PDB:3DL8" /db_xref="PDB:3IQM" /db_xref="PDB:3IQY" /db_xref="PDB:3JV2" /db_xref="PDB:5EUL" /db_xref="SubtiList:BG10741" /db_xref="UniProtKB/Swiss-Prot:P28366" /translation="MLGILNKMFDPTKRTLNRYEKIANDIDAIRGDYENLSDDALKHK TIEFKERLEKGATTDDLLVEAFAVVREASRRVTGMFPFKVQLMGGVALHDGNIAEMKT GEGKTLTSTLPVYLNALTGKGVHVVTVNEYLASRDAEQMGKIFEFLGLTVGLNLNSMS KDEKREAYAADITYSTNNELGFDYLRDNMVLYKEQMVQRPLHFAVIDEVDSILIDEAR TPLIISGQAAKSTKLYVQANAFVRTLKAEKDYTYDIKTKAVQLTEEGMTKAEKAFGID NLFDVKHVALNHHINQALKAHVAMQKDVDYVVEDGQVVIVDSFTGRLMKGRRYSEGLH QAIEAKEGLEIQNESMTLATITFQNYFRMYEKLAGMTGTAKTEEEEFRNIYNMQVVTI PTNRPVVRDDRPDLIYRTMEGKFKAVAEDVAQRYMTGQPVLVGTVAVETSELISKLLK NKGIPHQVLNAKNHEREAQIIEEAGQKGAVTIATNMAGRGTDIKLGEGVKELGGLAVV GTERHESRRIDNQLRGRSGRQGDPGITQFYLSMEDELMRRFGAERTMAMLDRFGMDDS TPIQSKMVSRAVESSQKRVEGNNFDSRKQLLQYDDVLRQQREVIYKQRFEVIDSENLR EIVENMIKSSLERAIAAYTPREELPEEWKLDGLVDLINTTYLDEGALEKSDIFGKEPD EMLELIMDRIITKYNEKEEQFGKEQMREFEKVIVLRAVDSKWMDHIDAMDQLRQGIHL RAYAQTNPLREYQMEGFAMFEHMIESIEDEVAKFVMKAEIENNLEREEVVQGQTTAHQ PQEGDDNKKAKKAPVRKVVDIGRNAPCHCGSGKKYKNCCGRTE*" /label="secA CDS" gene complement(3252633..3255158) /gene="secA" /locus_tag="BSU_35300" /old_locus_tag="BSU35300" /label="secA gene" S_feature complement(3255159..3255239) /Source="Nicolas_S_feature" /locus_tag="new_3630836_3630916_c" /HighExp="Etha, M9-stat, T0.30H, B60, dia5, Cold, dia15, Lbexp, Salt, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH, SigEF, SigD" /TUshortPSig="0.994, 0.997, 1, 1" /TUlongSig="SigA, SigD" /TUlongPSig="0.999, 1" /label="S1349" misc_feature complement(3255229..3255248) /Source="Nicolas_upshift_promotors" /id="U2766" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.69030969030969" /psig="0.994005994005994" /xcortree=106 /SigmaFactorBS="cggaaggtttttgtttttcttatttgcaaattctttggaaat aacaaaaggTATGATATGATAATGAGAGGtatacatggactagtaaattatttataca t" /listShort="S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3255239) /Source="Nicolas_upshifts" /id="U2766" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.69030969030969" /psig="0.994005994005994" /xcortree=106 /SigmaFactorBS="cggaaggtttttgtttttcttatttgcaaattctttggaaat aacaaaaggTATGATATGATAATGAGAGGtatacatggactagtaaattatttataca t" /listShort="S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3255326..3255895) /gene="hpf" /locus_tag="BSU_35310" /old_locus_tag="BSU35310" /function="16.6: Maintain" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11948165, 16324148, 17274076, 17277072, 19747895, 22720735, 22950019, 28468753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11948165, 16324148, 17274076, 17277072, 19747895, 22720735, 22950019, 28468753; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosome-associated sigma 54 modulation protein;ribosome dimerisation factor" /protein_id="NP_391411.1" /db_xref="EnsemblGenomes-Gn:BSU35310" /db_xref="EnsemblGenomes-Tr:CAB15548" /db_xref="GOA:P28368" /db_xref="InterPro:IPR003489" /db_xref="InterPro:IPR032528" /db_xref="InterPro:IPR034694" /db_xref="InterPro:IPR036567" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10740" /db_xref="UniProtKB/Swiss-Prot:P28368" /translation="MNYNIRGENIEVTPALKDHVERKIGKLERYFDHSVDADVNVNLK FYNDKESKVEVTIPMTDLALRSEVHNEDMYNAIDLATNKLERQIRKHKTKVNRKFREQ GSPKYLLANGLGSDTDIAVQDDIEEEESLDIVRQKRFNLKPMDSEEAILQMNMLGHNF FVFTNAETNLTNVVYRRNDGKYGLIEPTE*" /label="hpf CDS" gene complement(3255326..3255895) /gene="hpf" /locus_tag="BSU_35310" /old_locus_tag="BSU35310" /label="hpf gene" downshifts complement(3255334) /Source="Nicolas_upshifts" /id="D1830" /incds=0 /nref=78 /ntot=209 /MaxReadThrough="8.66806" /MaxDrop="4.7023" /score="29.9030506" /energy="-12.2" /TU="U2768,U2769,U2770,U2773" /idTUdmin="U2773" /TUdmin="-74" /isTUend="FALSE" /label="downshifts" promotor_-35 3255862..3255868 /Source="Nicolas_upshift_promotors" /id="U2767" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.365634365634366" /psig="0.829170829170829" /xcortree=289 /SigmaFactorBS="ttcctctcgacatgatcctttaacgcgggtgtcaCTTCAATa ttttctcctctGATGTTATAGTTCATCAAAGaacgcctcccttttattaaggatatgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3255881..3255900 /Source="Nicolas_upshift_promotors" /id="U2767" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.365634365634366" /psig="0.829170829170829" /xcortree=289 /SigmaFactorBS="ttcctctcgacatgatcctttaacgcgggtgtcaCTTCAATa ttttctcctctGATGTTATAGTTCATCAAAGaacgcctcccttttattaaggatatgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3255888 /Source="Nicolas_upshifts" /id="U2767" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.365634365634366" /psig="0.829170829170829" /xcortree=289 /SigmaFactorBS="ttcctctcgacatgatcctttaacgcgggtgtcaCTTCAATa ttttctcctctGATGTTATAGTTCATCAAAGaacgcctcccttttattaaggatatgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3255922..3255940) /Source="Nicolas_upshift_promotors" /id="U2768" /multdbtbs="SigB,SigH" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=499 /SigmaFactorBS="actgaattttcacaaaagatttatgtttcaGCAGGAATTgta aagggtaaAAGAGAAATAGATACATATccttaataaaagggaggcgttctttgatgaa c" /listShort="yvyD, S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3255930) /Source="Nicolas_upshifts" /id="U2768" /multdbtbs="SigB,SigH" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=499 /SigmaFactorBS="actgaattttcacaaaagatttatgtttcaGCAGGAATTgta aagggtaaAAGAGAAATAGATACATATccttaataaaagggaggcgttctttgatgaa c" /listShort="yvyD, S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3255932..3256052) /Source="Nicolas_S_feature" /locus_tag="new_3631609_3631729_c" /HighExp="C30, M0t90, S4, Lbstat, S5, M40t90, Glucon, Gly, C90, GM 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigD, SigD" /TUshortPSig="1, 1, 1" /TUlongSig="SigA" /TUlongPSig="0.999" /label="S1350" promotor_-35 complement(3255952..3255960) /Source="Nicolas_upshift_promotors" /id="U2768" /multdbtbs="SigB,SigH" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=499 /SigmaFactorBS="actgaattttcacaaaagatttatgtttcaGCAGGAATTgta aagggtaaAAGAGAAATAGATACATATccttaataaaagggaggcgttctttgatgaa c" /listShort="yvyD, S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3256036..3256054) /Source="Nicolas_upshift_promotors" /id="U2769" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1221 /SigmaFactorBS="tgtatggaaccctttttaatcaattaggcgtgtgtgaGGTAT TtgtttcgttcaatcaGCATATACATATACCTCCGaaccgccaataacagagcaaata c" /listShort="S1350, yvyD, S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3256052) /Source="Nicolas_upshifts" /id="U2769" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1221 /SigmaFactorBS="tgtatggaaccctttttaatcaattaggcgtgtgtgaGGTAT TtgtttcgttcaatcaGCATATACATATACCTCCGaaccgccaataacagagcaaata c" /listShort="S1350, yvyD, S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3256070..3256075) /Source="Nicolas_upshift_promotors" /id="U2769" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1221 /SigmaFactorBS="tgtatggaaccctttttaatcaattaggcgtgtgtgaGGTAT TtgtttcgttcaatcaGCATATACATATACCTCCGaaccgccaataacagagcaaata c" /listShort="S1350, yvyD, S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3256086..3256463) /gene="yvzG" /locus_tag="BSU_35319" /old_locus_tag="BSU35319" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097791.1" /db_xref="EnsemblGenomes-Gn:BSU35319" /db_xref="EnsemblGenomes-Tr:CAX52698" /db_xref="UniProtKB/Swiss-Prot:C0H3R9" /translation="MKSIEDYTLLSAYYHLLFTIEEGLCYLIEAEENLSKTEGDRIYQ DLIQAFFYLDSTHSTLLFIMDSRCAEICVKAFDQIFAEFDQLVSFSFPSHEFCEYLKE HFLIHYRKWMLSIHQCMEPFLIN*" /label="yvzG CDS" gene complement(3256086..3256463) /gene="yvzG" /locus_tag="BSU_35319" /old_locus_tag="BSU35319" /label="yvzG gene" CDS complement(3256473..3256814) /gene="fliT" /locus_tag="BSU_35320" /old_locus_tag="BSU35320" /function="16.3: Control" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12354229, 16952964; Product type s: structure" /codon_start=1 /transl_table=11 /product="flagellar assembly protein FliT involved in control of flagella expression" /protein_id="NP_391412.1" /db_xref="EnsemblGenomes-Gn:BSU35320" /db_xref="EnsemblGenomes-Tr:CAB15549" /db_xref="GOA:P39740" /db_xref="SubtiList:BG10923" /db_xref="UniProtKB/Swiss-Prot:P39740" /translation="MNNIDQLYTETKSMLSHIQNTPESDELLKQIEDFVATRSELIQE ISLPLSEEERKQMKLILTWDQLIVKEMERLKQSIATELQQMKRKRVMHTTYLNPYNNI TIDGTYYDKRK*" /label="fliT CDS" gene complement(3256473..3256814) /gene="fliT" /locus_tag="BSU_35320" /old_locus_tag="BSU35320" /label="fliT gene" CDS complement(3256811..3257212) /gene="fliS" /locus_tag="BSU_35330" /old_locus_tag="BSU35330" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12354229, 16806204, 16936039, 20534509, 23144244, 23874669; Product type s : structure" /codon_start=1 /transl_table=11 /product="flagellar assembly protein FliS" /protein_id="NP_391413.1" /db_xref="EnsemblGenomes-Gn:BSU35330" /db_xref="EnsemblGenomes-Tr:CAB15550" /db_xref="GOA:P39739" /db_xref="InterPro:IPR003713" /db_xref="InterPro:IPR036584" /db_xref="PDB:1VH6" /db_xref="SubtiList:BG10922" /db_xref="UniProtKB/Swiss-Prot:P39739" /translation="MAIQNPYTAYQQNSVNTATPGELTLMLYNGCLKFIRLAAQAIEN DDMERKNENLIKAQNIIQELNFTLNRNIELSASMGAMYDYMYRRLVQANIKNDTGMLA EVEGYVTDFRDAWKQAIQSERKDRHGSGGIA*" /label="fliS CDS" gene complement(3256811..3257212) /gene="fliS" /locus_tag="BSU_35330" /old_locus_tag="BSU35330" /label="fliS gene" CDS complement(3257234..3258730) /gene="fliD" /locus_tag="BSU_35340" /old_locus_tag="BSU35340" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9648743, 12354229, 24296669, 25355936; Product type s: structure" /codon_start=1 /transl_table=11 /product="flagellar hook-associated capping protein 2 (HAP2)" /protein_id="NP_391414.1" /db_xref="EnsemblGenomes-Gn:BSU35340" /db_xref="EnsemblGenomes-Tr:CAB15551" /db_xref="GOA:P39738" /db_xref="InterPro:IPR003481" /db_xref="InterPro:IPR010809" /db_xref="InterPro:IPR010810" /db_xref="SubtiList:BG10921" /db_xref="UniProtKB/Swiss-Prot:P39738" /translation="MVTRITGLASGMDIDDIVSKLMQTERAPLDKLTQKKQTLEWQRD SYREVNSKIKELQDYMSKNTLTYPSTYQSKTVTSSNESVLTATGSVSAPNSSSTVEVA SLATAATYKANNYTGYTQGDYNLAFNVVAPGETTAKTVNISVTSADTIDNVISKLNSS DLGVSAFKDKIWNGTEYVETIAFSSKATGAGGSIQAADSATADFMSGQLGFSLDADNK LTAYKEGTNAKVTINGFEMEKLTNNFTVNGVTYSIKNTTAATGPVTTSVSTDVDGIYN QIKEFVDKYNELVDSLNEKLKEEKYRDYTPLTSEQKEAMSDKEVELWEEKAKSGLLRN DSSISTGTNQMRTDFYTQVNADGKTYQLTEFGITTSSAYQLRGHLEINEEKLKAKIAE DPQGVANLFTSGTNDSNYSDKGIMKRITNTLRSTVKSIEAKAGNSTMGASSYSIGKNL NSISTEITDMQDRLNTIENRYYSKFSAMDSAIQKMNEQASYLSQLLVQ*" /label="fliD CDS" gene complement(3257234..3258730) /gene="fliD" /locus_tag="BSU_35340" /old_locus_tag="BSU35340" /label="fliD gene" CDS complement(3258748..3259077) /gene="yvyC" /locus_tag="BSU_35350" /old_locus_tag="BSU35350" /function="16.13: Shape" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12354229, 19455708; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative flagellar protein of unknown function" /protein_id="NP_391415.1" /db_xref="EnsemblGenomes-Gn:BSU35350" /db_xref="EnsemblGenomes-Tr:CAB15552" /db_xref="InterPro:IPR005186" /db_xref="InterPro:IPR035924" /db_xref="PDB:2HC5" /db_xref="SubtiList:BG10920" /db_xref="UniProtKB/Swiss-Prot:P39737" /translation="MNIERLTTLQPVWDRYDTQIHNQKDNDNEVPVHQVSYTNLAEMV GEMNKLLEPSQVHLKFELHDKLNEYYVKVIEDSTNEVIREIPPKRWLDFYAAMTEFLG LFVDEKK*" /label="yvyC CDS" gene complement(3258748..3259077) /gene="yvyC" /locus_tag="BSU_35350" /old_locus_tag="BSU35350" /label="yvyC gene" downshifts 3259074 /Source="Nicolas_upshifts" /id="D1831" /incds=0 /nref=33 /ntot=140 /MaxReadThrough="2.74277" /MaxDrop="4.24086" /score="8.30527041" /energy="-10.1" /TU="NA" /idTUdmin="U2774" /TUdmin="-3062" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3259099..3259117) /Source="Nicolas_upshift_promotors" /id="U2770" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2807 /SigmaFactorBS="agaaatctaaaacagaagatttttttccaaaaatatGTGTAA TCttatctcgacttaGTCGATATAAACGATAGATtggggcataggggatgatcaattg a" /listShort="yvyC, fliD, fliS, fliT, yvzG, S1350, yvyD, S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3259114) /Source="Nicolas_upshifts" /id="U2770" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2807 /SigmaFactorBS="agaaatctaaaacagaagatttttttccaaaaatatGTGTAA TCttatctcgacttaGTCGATATAAACGATAGATtggggcataggggatgatcaattg a" /listShort="yvyC, fliD, fliS, fliT, yvzG, S1350, yvyD, S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3259116..3259220) /Source="Nicolas_S_feature" /locus_tag="new_3634793_3634897_c" /HighExp="Lbstat, Cold, Gly, S0, Glu, Pyr, M/G, M0t90, C30, Fru" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1351" promotor_-35 complement(3259131..3259138) /Source="Nicolas_upshift_promotors" /id="U2770" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2807 /SigmaFactorBS="agaaatctaaaacagaagatttttttccaaaaatatGTGTAA TCttatctcgacttaGTCGATATAAACGATAGATtggggcataggggatgatcaattg a" /listShort="yvyC, fliD, fliS, fliT, yvzG, S1350, yvyD, S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(3259209..3259228) /Source="Nicolas_upshift_promotors" /id="U2771" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=2693 /SigmaFactorBS="tcttttaatttaaatttctatctcctaatcattcctcatcct gtcactaactCATGATATAATAACCGGATTctccactaactttttataaatgtatttc c" /listShort="S1351, yvyC, fliD, fliS, fliT, yvzG" /listLong="S1350, yvyD, S1349, secA, S1348, prfB" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3259220) /Source="Nicolas_upshifts" /id="U2771" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=2693 /SigmaFactorBS="tcttttaatttaaatttctatctcctaatcattcctcatcct gtcactaactCATGATATAATAACCGGATTctccactaactttttataaatgtatttc c" /listShort="S1351, yvyC, fliD, fliS, fliT, yvzG" /listLong="S1350, yvyD, S1349, secA, S1348, prfB" /label="upshifts" CDS complement(3259310..3260224) /gene="hag" /locus_tag="BSU_35360" /old_locus_tag="BSU35360" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:8045886, 9648743, 12730172, 14762011, 15342569, 22720735, 25355936, 28800172, 29124898" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045886, 9648743, 12730172, 14762011, 15342569, 22720735, 25355936, 28800172, 29124898; Product type s: structure" /codon_start=1 /transl_table=11 /product="flagellin protein" /protein_id="NP_391416.1" /db_xref="EnsemblGenomes-Gn:BSU35360" /db_xref="EnsemblGenomes-Tr:CAB15553" /db_xref="GOA:P02968" /db_xref="InterPro:IPR001029" /db_xref="InterPro:IPR001492" /db_xref="SubtiList:BG10655" /db_xref="UniProtKB/Swiss-Prot:P02968" /translation="MRINHNIAALNTLNRLSSNNSASQKNMEKLSSGLRINRAGDDAA GLAISEKMRGQIRGLEMASKNSQDGISLIQTAEGALTETHAILQRVRELVVQAGNTGT QDKATDLQSIQDEISALTDEIDGISNRTEFNGKKLLDGTYKVDTATPANQKNLVFQIG ANATQQISVNIEDMGADALGIKEADGSIAALHSVNDLDVTKFADNAADTADIGFDAQL KVVDEAINQVSSQRAKLGAVQNRLEHTINNLSASGENLTAAESRIRDVDMAKEMSEFT KNNILSQASQAMLAQANQQPQNVLQLLR*" /label="hag CDS" gene complement(3259310..3260224) /gene="hag" /locus_tag="BSU_35360" /old_locus_tag="BSU35360" /label="hag gene" downshifts complement(3259330) /Source="Nicolas_upshifts" /id="D1832" /incds=0 /nref=165 /ntot=233 /MaxReadThrough="5.58531" /MaxDrop="7.10921" /score="11.6997504" /energy="-13.1" /TU="U2773" /idTUdmin="U2775" /TUdmin=1078 /isTUend="FALSE" /label="downshifts" S_feature complement(3260225..3260333) /Source="Nicolas_S_feature" /locus_tag="new_3635902_3636010_c" /HighExp="T2.0H, Glucon, M0t90, T2.30H, GM 15, T-0.40H, GM 10, T1.0H, T-1.10H, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1352" promotor_-35 3260291..3260292 /Source="Nicolas_upshift_promotors" /id="U2772" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.997002997002997" /psig=0 /xcortree=717 /SigmaFactorBS="gttaaggcacgtccttgtgcccttattttgtaactggctgaG TcttttgcgCCTCCTCCCGGCTACatcattaatatcggattgtctctgattttgttaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3260301..3260315 /Source="Nicolas_upshift_promotors" /id="U2772" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.997002997002997" /psig=0 /xcortree=717 /SigmaFactorBS="gttaaggcacgtccttgtgcccttattttgtaactggctgaG TcttttgcgCCTCCTCCCGGCTACatcattaatatcggattgtctctgattttgttaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3260310 /Source="Nicolas_upshifts" /id="U2772" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.997002997002997" /psig=0 /xcortree=717 /SigmaFactorBS="gttaaggcacgtccttgtgcccttattttgtaactggctgaG TcttttgcgCCTCCTCCCGGCTACatcattaatatcggattgtctctgattttgttaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3260312..3260330) /Source="Nicolas_upshift_promotors" /id="U2773" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2833 /SigmaFactorBS="cgcattatcctcacaaaaaaagtgaggatttttttatttttg tATTAACAAaatcagagacaaTCCGATATTAATGATGTAGccgggaggaggcgcaaaa g" /listShort="S1352, hag, S1351, yvyC, fliD, fliS, fliT, yvzG, S1350, yvyD" /listLong="S1349, secA, S1348, prfB" /label="promotor_-10" upshifts complement(3260333) /Source="Nicolas_upshifts" /id="U2773" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2833 /SigmaFactorBS="cgcattatcctcacaaaaaaagtgaggatttttttatttttg tATTAACAAaatcagagacaaTCCGATATTAATGATGTAGccgggaggaggcgcaaaa g" /listShort="S1352, hag, S1351, yvyC, fliD, fliS, fliT, yvzG, S1350, yvyD" /listLong="S1349, secA, S1348, prfB" /label="upshifts" promotor_-35 complement(3260343..3260350) /Source="Nicolas_upshift_promotors" /id="U2773" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2833 /SigmaFactorBS="cgcattatcctcacaaaaaaagtgaggatttttttatttttg tATTAACAAaatcagagacaaTCCGATATTAATGATGTAGccgggaggaggcgcaaaa g" /listShort="S1352, hag, S1351, yvyC, fliD, fliS, fliT, yvzG, S1350, yvyD" /listLong="S1349, secA, S1348, prfB" /label="promotor_-35" CDS complement(3260369..3260593) /gene="csrA" /locus_tag="BSU_35370" /old_locus_tag="BSU35370" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8982093, 17555441, 21895793, 23144244, 27516547" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8982093, 17555441, 21895793, 23144244, 27516547; Product type r: regulator" /codon_start=1 /transl_table=11 /product="carbon storage regulator" /protein_id="NP_391417.1" /db_xref="EnsemblGenomes-Gn:BSU35370" /db_xref="EnsemblGenomes-Tr:CAB15554" /db_xref="GOA:P33911" /db_xref="InterPro:IPR003751" /db_xref="InterPro:IPR036107" /db_xref="PDB:1T3O" /db_xref="SubtiList:BG10654" /db_xref="UniProtKB/Swiss-Prot:P33911" /translation="MLVLSRKINEAIQIGADIEVKVIAVEGDQVKLGIDAPKHIDIHR KEIYLTIQEENNRAAALSSDVISALSSQKK*" /label="csrA CDS" gene complement(3260369..3260593) /gene="csrA" /locus_tag="BSU_35370" /old_locus_tag="BSU35370" /label="csrA gene" downshifts complement(3260408) /Source="Nicolas_upshifts" /id="D1833" /incds=0 /nref=22 /ntot=171 /MaxReadThrough="2.28652" /MaxDrop="3.46262" /score="31.5820557" /energy="-9.2" /TU="NA" /idTUdmin="U2775" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3260587..3261018) /gene="fliW" /locus_tag="BSU_35380" /old_locus_tag="BSU35380" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15033535, 16936039, 21895793, 27516547" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15033535, 16936039, 21895793, 27516547; Product type f: factor" /codon_start=1 /transl_table=11 /product="assembly factor of the flagellum" /protein_id="NP_391418.1" /db_xref="EnsemblGenomes-Gn:BSU35380" /db_xref="EnsemblGenomes-Tr:CAB15555" /db_xref="GOA:P96503" /db_xref="InterPro:IPR003775" /db_xref="InterPro:IPR024046" /db_xref="SubtiList:BG12451" /db_xref="UniProtKB/Swiss-Prot:P96503" /translation="MIIHTKYHGQMNIKEEQIILFESGIPGFLEEKQFVILPLSEDSP FVALQSVTSENLAFIVVSPFIFFKNYEFDLDESTAELLDIDNIQDVEVMTILTMAEPF EKSTANLLAPIIVNRKNMMAKQVVLHDSSYTTKHPIGGESC*" /label="fliW CDS" gene complement(3260587..3261018) /gene="fliW" /locus_tag="BSU_35380" /old_locus_tag="BSU35380" /label="fliW gene" CDS complement(3261039..3261614) /gene="yviE" /locus_tag="BSU_35390" /old_locus_tag="BSU35390" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15033535" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391419.1" /db_xref="EnsemblGenomes-Gn:BSU35390" /db_xref="EnsemblGenomes-Tr:CAB15556" /db_xref="SubtiList:BG12450" /db_xref="UniProtKB/Swiss-Prot:P96502" /translation="MQIPRLIMHSVQGKIGLTTTPASLKMEQPQADLEIEQPSAEMEI SVTPGKLTIDQTQAWEELDRKHVFKRIEEAAQQGHEDVMEGIARTAEEGDELMKIENK GNPIASQARRNSEMHQIQLGENYAPSLSRVKIQYTPSQLDVQITPRKPVIQAEPHKPI VEYTPGNVKVDMLQYPDLNIDVEYPKESPEK*" /label="yviE CDS" gene complement(3261039..3261614) /gene="yviE" /locus_tag="BSU_35390" /old_locus_tag="BSU35390" /label="yviE gene" CDS complement(3261661..3262557) /gene="flgL" /locus_tag="BSU_35400" /old_locus_tag="BSU35400" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2407720, 15033535, 17438286, 23874669, 24296669, 24706744; Product type s : structure" /codon_start=1 /transl_table=11 /product="flagellar hook-filament junction protein" /protein_id="NP_391420.1" /db_xref="EnsemblGenomes-Gn:BSU35400" /db_xref="EnsemblGenomes-Tr:CAB15557" /db_xref="GOA:P96501" /db_xref="InterPro:IPR001029" /db_xref="InterPro:IPR013384" /db_xref="SubtiList:BG11936" /db_xref="UniProtKB/Swiss-Prot:P96501" /translation="MRVTQGMIQQNSLRYIGSSYSKLDKLQSQISSGKKISKASDDPV VAMKSLKYNTQLSQVQQYKSNASQAFTWLENTETNITEGIDILSKVRELAVEAQNDTN GEPERQAIGVEVKQLKEQLLNIANTQVNGRYIFNGTNSDKPPVTDNGDGTYTISDTAD VVVNISNNMSLKVNSDPKSAFGGTSESGQNVFEMLDSFEKALNSGSLDGMDSVLNDID HFSDGMSAERSDLGARYNRLELVNTRLSAQEETATKVLSDNEDVELEEVITEFIAQQS VHRATLAVNAQIVQPTLIDFLK*" /label="flgL CDS" gene complement(3261661..3262557) /gene="flgL" /locus_tag="BSU_35400" /old_locus_tag="BSU35400" /label="flgL gene" downshifts complement(3261684) /Source="Nicolas_upshifts" /id="D1834" /incds=0 /nref=112 /ntot=251 /MaxReadThrough="5.50861" /MaxDrop="3.8234" /score="0.376587888" /energy="-4.8" /TU="U2775,U2776,U2777" /idTUdmin="U2777" /TUdmin="-1254" /isTUend="FALSE" /label="downshifts" misc_feature 3261973..3261976 /Source="Nicolas_upshift_promotors" /id="U2774" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.97902097902098" /psig="0.000999000999001" /xcortree=54 /SigmaFactorBS="actgtccatgccatctagcgaaccagaatttagtgctttctc aaaagaatcAAGCatttcaaatacattctgcccgctttcagaagtgcctccaaaagct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3261982 /Source="Nicolas_upshifts" /id="U2774" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.97902097902098" /psig="0.000999000999001" /xcortree=54 /SigmaFactorBS="actgtccatgccatctagcgaaccagaatttagtgctttctc aaaagaatcAAGCatttcaaatacattctgcccgctttcagaagtgcctccaaaagct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3262568..3264091) /gene="flgK" /locus_tag="BSU_35410" /old_locus_tag="BSU35410" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2407720, 15033535, 17438286, 23874669, 24296669, 24706744; Product type s : structure" /codon_start=1 /transl_table=11 /product="flagellar hook-filament junction" /protein_id="NP_391421.1" /db_xref="EnsemblGenomes-Gn:BSU35410" /db_xref="EnsemblGenomes-Tr:CAB15558" /db_xref="GOA:P39810" /db_xref="InterPro:IPR001444" /db_xref="InterPro:IPR002371" /db_xref="InterPro:IPR010930" /db_xref="InterPro:IPR019776" /db_xref="SubtiList:BG10401" /db_xref="UniProtKB/Swiss-Prot:P39810" /translation="MTSTFMGLETARRALSAQQAALSTTANNVANANTDGYTRQRVSL EATDYFPAVSKNAEKTAGQMGTGVQGKSVERIRDIFLDYQYRLQNNSAGYYDTKAKAL SQMEGVLNETDDSGLNSVLNSFWNSLQELSNNTNEESARSVVARKGQAVAETFNYISE SLTNVQSNLKAELNTTVLDVNSLLSQLNSLNKQIAQVEPVGLLPNGLYDQRDLLIDKL SSMVDIKVSYNKSGGNALASAEGTVSIEILDKNKQSLGTVLDGKNYEVSELAANYDNE TGLVSSISIGDTAVQAESFSSKGSLLGFIESYGYITADGQEKGVYPEMLSDLDNMALE FAKAFNEVHRNGVTKSGEQGGDFFDFTGGETEPAKGAAGKIKVADSIIDSKGANIAFS LTGAANDNANATKLANVLTGKITINGKETSVLDYYAGLIGELGIEAQEANRLASNTET QLNDADINRQQMSAVSLDEEMTNMIQFQHAYNAAARMVTLQDELLDKVINGMGVGGR* " /label="flgK CDS" gene complement(3262568..3264091) /gene="flgK" /locus_tag="BSU_35410" /old_locus_tag="BSU35410" /label="flgK gene" CDS complement(3264110..3264592) /gene="flgN" /locus_tag="BSU_35420" /old_locus_tag="BSU35420" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:24706744" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 24706744; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor required for flagellar based motility" /protein_id="NP_391422.1" /db_xref="EnsemblGenomes-Gn:BSU35420" /db_xref="EnsemblGenomes-Tr:CAB15559" /db_xref="GOA:P39808" /db_xref="InterPro:IPR007809" /db_xref="InterPro:IPR036679" /db_xref="SubtiList:BG10400" /db_xref="UniProtKB/Swiss-Prot:P39808" /translation="MSAKAIIEQLKRLCVLHEHLLTLSEEKTEALKAGKTKELSNILT KEQKYIQAITQTEDDRIKTTSAFLGYSENNTISACIAKTSGSEKEELEQLYESLSQVL GRLKKVNEMNRQLTRDALQFISISYDMLVPKENNFNYSKSIKAELPKSSKMKLFDSKA *" /label="flgN CDS" gene complement(3264110..3264592) /gene="flgN" /locus_tag="BSU_35420" /old_locus_tag="BSU35420" /label="flgN gene" CDS complement(3264608..3264874) /gene="flgM" /locus_tag="BSU_35430" /old_locus_tag="BSU35430" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10207036, 10322161, 14762011, 16673084, 21736639, 22720735, 25313396" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10207036, 10322161, 14762011, 16673084, 21736639, 22720735, 25313396; Product type r: regulator" /codon_start=1 /transl_table=11 /product="anti-sigma factor repressor of sigma(D)-dependent transcription" /protein_id="NP_391423.1" /db_xref="EnsemblGenomes-Gn:BSU35430" /db_xref="EnsemblGenomes-Tr:CAB15560" /db_xref="GOA:P39809" /db_xref="InterPro:IPR007412" /db_xref="InterPro:IPR031316" /db_xref="InterPro:IPR035890" /db_xref="SubtiList:BG10399" /db_xref="UniProtKB/Swiss-Prot:P39809" /translation="MKINQFGTQSVNPYQKNYDKQAVQKTVAQPQDKIEISSQAKEMQ HASDAVTGSRQEKIAQLKAQIENGSYKVDANHIAKNMINFYKKQ*" /label="flgM CDS" gene complement(3264608..3264874) /gene="flgM" /locus_tag="BSU_35430" /old_locus_tag="BSU35430" /label="flgM gene" S_feature complement(3264875..3264954) /Source="Nicolas_S_feature" /locus_tag="new_3640552_3640631_c" /HighExp="T0.30H, Cold, C90, T-5.40H, T-4.40H, GM 150, T-2.40H, GM 45, S2, GM 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA, SigA" /TUshortPSig="1, 1, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1353" CDS complement(3264955..3265374) /gene="yvyF" /locus_tag="BSU_35440" /old_locus_tag="BSU35440" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9696775; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator of flagella formation" /protein_id="NP_391424.1" /db_xref="EnsemblGenomes-Gn:BSU35440" /db_xref="EnsemblGenomes-Tr:CAB15561" /db_xref="GOA:P39807" /db_xref="InterPro:IPR022258" /db_xref="SubtiList:BG10398" /db_xref="UniProtKB/Swiss-Prot:P39807" /translation="MGELANCPKCNALFLKTKLQTVCQACIKEEEKSFETVYKFLRKQ ENRQSTLSRITEETGVEEELILKFIRQKRIQITHLPNLAYPCERCGTSIREGKFCKAC QSDIKDQMDHLNHEDALKIEKENSKKDTYYAYNTKNS*" /label="yvyF CDS" gene complement(3264955..3265374) /gene="yvyF" /locus_tag="BSU_35440" /old_locus_tag="BSU35440" /label="yvyF gene" promotor_-10 complement(3265413..3265431) /Source="Nicolas_upshift_promotors" /id="U2775" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2812 /SigmaFactorBS="cgcttcagtgtcatcttttaccttgatcagaaGCTAAATGat tctgtttttatGCCGATATAATCACTAGAAattgacacaggcatattatctaataagg a" /listShort="yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3265424) /Source="Nicolas_upshifts" /id="U2775" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2812 /SigmaFactorBS="cgcttcagtgtcatcttttaccttgatcagaaGCTAAATGat tctgtttttatGCCGATATAATCACTAGAAattgacacaggcatattatctaataagg a" /listShort="yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3265445..3265452) /Source="Nicolas_upshift_promotors" /id="U2775" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2812 /SigmaFactorBS="cgcttcagtgtcatcttttaccttgatcagaaGCTAAATGat tctgtttttatGCCGATATAATCACTAGAAattgacacaggcatattatctaataagg a" /listShort="yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3265448..3266170) /gene="comFC" /locus_tag="BSU_35450" /old_locus_tag="BSU35450" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8045879, 8412657, 16009133, 28618091" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045879, 8412657, 16009133, 28618091; Product type t: transporter" /codon_start=1 /transl_table=11 /product="component of the DNA transport apparatus" /protein_id="NP_391425.2" /db_xref="EnsemblGenomes-Gn:BSU35450" /db_xref="EnsemblGenomes-Tr:CAB15562" /db_xref="GOA:P39147" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR005222" /db_xref="InterPro:IPR029057" /db_xref="SubtiList:BG10397" /db_xref="UniProtKB/Swiss-Prot:P39147" /translation="MSNEAGGGIHKLICLLCDSQFSQDVTWRALFLLKPDEKVCYSCR SKLKKITGHICPLCGRPQSVHAVCRDCEVWRTRIRDSLLLRQNRSVYTYNDMMKETLS RFKFRGDAEIINAFKSDFSSTFSKVYPDKHFVLVPIPLSKEREEERGFNQAHLLAECL DRPSHHPLIRLNNEKQSKKKKTERLLSECIFDTKNNSAEGMNIILIDDLYTTGATLHF AARCLLEKGKAASVSSFTLIRS*" /label="comFC CDS" gene complement(3265448..3266170) /gene="comFC" /locus_tag="BSU_35450" /old_locus_tag="BSU35450" /label="comFC gene" CDS complement(3266134..3266430) /gene="comFB" /locus_tag="BSU_35460" /old_locus_tag="BSU35460" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8045879, 8412657, 16009133, 25423369" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045879, 8412657, 16009133, 25423369; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of competence, pole located" /protein_id="NP_391426.1" /db_xref="EnsemblGenomes-Gn:BSU35460" /db_xref="EnsemblGenomes-Tr:CAB15563" /db_xref="GOA:P39146" /db_xref="InterPro:IPR019657" /db_xref="PDB:4WAI" /db_xref="SubtiList:BG10396" /db_xref="UniProtKB/Swiss-Prot:P39146" /translation="MLVNSKEIVMKELLDRYMDQLHMACTCQVCQNDVLALSLNKVSP SYVTDFKKIAYTKAELVDKQKNTAMLVILAESAAVVSESPSDLCQTKQEEAFIN*" /label="comFB CDS" gene complement(3266134..3266430) /gene="comFB" /locus_tag="BSU_35460" /old_locus_tag="BSU35460" /label="comFB gene" promotor_-10 complement(3266456..3266475) /Source="Nicolas_upshift_promotors" /id="U2776" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.797202797202797" /psig=1 /xcortree=2253 /SigmaFactorBS="aatgaatgaattggcagcaaaagttgaatgtacagaCTAGCC ATtatttgaaaaCGTGGTACAGTATACTCATAtaaccgatgatgaggagctgtaaaaa t" /listShort="comFB, comFC, yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3266469) /Source="Nicolas_upshifts" /id="U2776" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.797202797202797" /psig=1 /xcortree=2253 /SigmaFactorBS="aatgaatgaattggcagcaaaagttgaatgtacagaCTAGCC ATtatttgaaaaCGTGGTACAGTATACTCATAtaaccgatgatgaggagctgtaaaaa t" /listShort="comFB, comFC, yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3266486..3266493) /Source="Nicolas_upshift_promotors" /id="U2776" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.797202797202797" /psig=1 /xcortree=2253 /SigmaFactorBS="aatgaatgaattggcagcaaaagttgaatgtacagaCTAGCC ATtatttgaaaaCGTGGTACAGTATACTCATAtaaccgatgatgaggagctgtaaaaa t" /listShort="comFB, comFC, yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3266490..3267881) /gene="comFA" /locus_tag="BSU_35470" /old_locus_tag="BSU35470" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8045895, 11359569, 12123453, 16009133, 21397556, 28559293" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045895, 11359569, 12123453, 16009133, 21397556, 28559293; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent helicase competence protein" /protein_id="NP_391427.1" /db_xref="EnsemblGenomes-Gn:BSU35470" /db_xref="EnsemblGenomes-Tr:CAB15564" /db_xref="GOA:P39145" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR006935" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10395" /db_xref="UniProtKB/Swiss-Prot:P39145" /translation="MNVPVEKNSSFSKELQQTLRSRHLLRTELSFSDEMIEWHIKNGY ITAENSISINKRRYRCNRCGQTDQRYFSFYHSSGKNKLYCRSCVMMGRVSEEVPLYSW KEENESNWKSIKLTWDGKLSSGQQKAANVLIEAISKKEELLIWAVCGAGKTEMLFPGI ESALNQGLRVCIATPRTDVVLELAPRLKAAFQGADISALYGGSDDKGRLSPLMISTTH QLLRYKDAIDVMIIDEVDAFPYSADQTLQFAVQKARKKNSTLVYLSATPPKELKRKAL NGQLHSVRIPARHHRKPLPEPRFVWCGNWKKKLNRNKIPPAVKRWIEFHVKEGRPVFL FVPSVSILEKAAACFKGVHCRTASVHAEDKHRKEKVQQFRDGQLDLLITTTILERGVT VPKVQTGVLGAESSIFTESALVQIAGRTGRHKEYADGDVIYFHFGKTKSMLDARKHIK EMNELAAKVECTD*" /label="comFA CDS" gene complement(3266490..3267881) /gene="comFA" /locus_tag="BSU_35470" /old_locus_tag="BSU35470" /label="comFA gene" promotor_-10 complement(3267895..3267914) /Source="Nicolas_upshift_promotors" /id="U2777" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.992007992007992" /psig="0.997002997002997" /xcortree=2970 /SigmaFactorBS="ttagagcggagatttttttatattcttattttaatAGTTGGA CagaaaatattcatTCAGGCATACTGTTTCGAAAggaggcgtgctatgtgaatgtgcc a" /listShort="comFA, comFB, comFC, yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3267910) /Source="Nicolas_upshifts" /id="U2777" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.992007992007992" /psig="0.997002997002997" /xcortree=2970 /SigmaFactorBS="ttagagcggagatttttttatattcttattttaatAGTTGGA CagaaaatattcatTCAGGCATACTGTTTCGAAAggaggcgtgctatgtgaatgtgcc a" /listShort="comFA, comFB, comFC, yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3267928..3267935) /Source="Nicolas_upshift_promotors" /id="U2777" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.992007992007992" /psig="0.997002997002997" /xcortree=2970 /SigmaFactorBS="ttagagcggagatttttttatattcttattttaatAGTTGGA CagaaaatattcatTCAGGCATACTGTTTCGAAAggaggcgtgctatgtgaatgtgcc a" /listShort="comFA, comFB, comFC, yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3267987..3268832) /gene="fakBA" /locus_tag="BSU_35480" /old_locus_tag="BSU35480" /EC_number="2.7.2.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:3926750, 17114254, 19390149, 22720735, 25002480, 26774272, 27435445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3926750, 17114254, 19390149, 22720735, 25002480, 26774272, 27435445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fatty acid kinase fatty acid binding subunit A" /protein_id="NP_391428.1" /db_xref="EnsemblGenomes-Gn:BSU35480" /db_xref="EnsemblGenomes-Tr:CAB15565" /db_xref="GOA:P32436" /db_xref="InterPro:IPR003797" /db_xref="PDB:3FYS" /db_xref="SubtiList:BG10394" /db_xref="UniProtKB/Swiss-Prot:P32436" /translation="MNIAVVTDSTAYIPKEMREQHQIHMIPLQVVFREETYREEIELD WKSFYEEVKKHNELPTTSQPPIGELVALYEELGKSYDAVISIHLSSGISGTFSSAAAA DSMVDNIDVYPFDSEISCLAQGFYALKAAELIKNGASSPEDIIKELEEMKKTVRAYFM VDDLAHLQRGGRLSSAQAFIGSLLKVKPILHFDNKVIVPFEKIRTRKKAISRIYELLD EDASKGLPMRAAVIHANREEEAAKIIEELSAKYPHVEFYNSYFGAVIGTHLGEGALGI CWCFK*" /label="fakBA CDS" gene complement(3267987..3268832) /gene="fakBA" /locus_tag="BSU_35480" /old_locus_tag="BSU35480" /label="fakBA gene" downshifts complement(3267998) /Source="Nicolas_upshifts" /id="D1835" /incds=0 /nref=207 /ntot=249 /MaxReadThrough="2.43976" /MaxDrop="5.65998" /score="25.7738948" /energy="-9.9" /TU="NA" /idTUdmin="U2779" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 3268249..3268256 /Source="Nicolas_upshift_promotors" /id="U2778" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.897102897102897" /psig="0.978021978021978" /xcortree=2971 /SigmaFactorBS="tgcgaatcttctcaaaaggcacaattaccTTATTGTCaaaat gaaggataGGCTTTACCTTTAGAAGACTaccaatgaaggcttgggcgctgcttaatcg c" /listShort="S1354" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3268270..3268289 /Source="Nicolas_upshift_promotors" /id="U2778" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.897102897102897" /psig="0.978021978021978" /xcortree=2971 /SigmaFactorBS="tgcgaatcttctcaaaaggcacaattaccTTATTGTCaaaat gaaggataGGCTTTACCTTTAGAAGACTaccaatgaaggcttgggcgctgcttaatcg c" /listShort="S1354" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3268280..3270012 /Source="Nicolas_S_feature" /locus_tag="new_3643957_3645689" /HighExp="C30, S2, C90, Pyr, T0.30H, GM 150, G/S, T-4.40H, T-3.40H, T1.30H" /AntisenseName="degU" /AntisenseCor="1.0564647169900101E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.978" /TUlongSig="NA" /TUlongPSig="NA" /label="S1354" upshifts 3268280 /Source="Nicolas_upshifts" /id="U2778" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.897102897102897" /psig="0.978021978021978" /xcortree=2971 /SigmaFactorBS="tgcgaatcttctcaaaaggcacaattaccTTATTGTCaaaat gaaggataGGCTTTACCTTTAGAAGACTaccaatgaaggcttgggcgctgcttaatcg c" /listShort="S1354" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3268859..3268878) /Source="Nicolas_upshift_promotors" /id="U2779" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.998001998001998" /xcortree=2329 /SigmaFactorBS="atgagatagtataataggagacttgccttttactaggcaggt CTTTttttaggctgccgtTTCCCTTACAATAGAGTTATaaagcaataaggcaggtatc g" /listShort="yviA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3268878) /Source="Nicolas_upshifts" /id="U2779" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.998001998001998" /xcortree=2329 /SigmaFactorBS="atgagatagtataataggagacttgccttttactaggcaggt CTTTttttaggctgccgtTTCCCTTACAATAGAGTTATaaagcaataaggcaggtatc g" /listShort="yviA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3268893..3268896) /Source="Nicolas_upshift_promotors" /id="U2779" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.998001998001998" /xcortree=2329 /SigmaFactorBS="atgagatagtataataggagacttgccttttactaggcaggt CTTTttttaggctgccgtTTCCCTTACAATAGAGTTATaaagcaataaggcaggtatc g" /listShort="yviA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3268930..3269619) /gene="degU" /locus_tag="BSU_35490" /old_locus_tag="BSU35490" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10908654, 11557812, 12471443, 12950930, 14563871, 15342569, 15598897, 17590234, 17827323, 21736639, 22677979, 24847778, 25288929, 25880922, 25887289, 27920766" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10908654, 11557812, 12471443, 12950930, 14563871, 15342569, 15598897, 17590234, 17827323, 21736639, 22677979, 24847778, 25288929, 25880922, 25887289, 27920766; Product type r : regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator" /protein_id="NP_391429.1" /db_xref="EnsemblGenomes-Gn:BSU35490" /db_xref="EnsemblGenomes-Tr:CAB15566" /db_xref="GOA:P13800" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10393" /db_xref="UniProtKB/Swiss-Prot:P13800" /translation="MTKVNIVIIDDHQLFREGVKRILDFEPTFEVVAEGDDGDEAARI VEHYHPDVVIMDINMPNVNGVEATKQLVELYPESKVIILSIHDDENYVTHALKTGARG YLLKEMDADTLIEAVKVVAEGGSYLHPKVTHNLVNEFRRLATSGVSAHPQHEVYPEIR RPLHILTRRECEVLQMLADGKSNRGIGESLFISEKTVKNHVSNILQKMNVNDRTQAVV VAIKNGWVEMR*" /label="degU CDS" gene complement(3268930..3269619) /gene="degU" /locus_tag="BSU_35490" /old_locus_tag="BSU35490" /label="degU gene" downshifts complement(3268944) /Source="Nicolas_upshifts" /id="D1836" /incds=0 /nref=178 /ntot=235 /MaxReadThrough="5.12878" /MaxDrop="6.38336" /score="20.9249268" /energy="-12.8" /TU="U2781" /idTUdmin="U2779" /TUdmin="-946" /isTUend="FALSE" /label="downshifts" S_feature complement(3269620..3269701) /Source="Nicolas_S_feature" /locus_tag="new_3645297_3645378_c" /HighExp="M40t90, Lbtran, M0t90, LBGtran, G180, T3.0H, M40t45, C90, T3.30H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1355" CDS complement(3269702..3270859) /gene="degS" /locus_tag="BSU_35500" /old_locus_tag="BSU35500" /EC_number="2.7.3.-" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:10908654, 11557812, 12471443, 12950930, 14563871, 15342569, 15598897, 17590234, 17827323, 21736639, 22677979, 24847778, 25288929, 25880922, 25887289, 27920766" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10908654, 11557812, 12471443, 12950930, 14563871, 15342569, 15598897, 17590234, 17827323, 21736639, 22677979, 24847778, 25288929, 25880922, 25887289, 27920766; Product type rc : receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [DegU]" /protein_id="NP_391430.1" /db_xref="EnsemblGenomes-Gn:BSU35500" /db_xref="EnsemblGenomes-Tr:CAB15567" /db_xref="GOA:P13799" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR008595" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR016381" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10392" /db_xref="UniProtKB/Swiss-Prot:P13799" /translation="MNKTKMDSKVLDSILMKMLKTVDGSKDEVFQIGEQSRQQYEQLV EELKQIKQQVYEVIELGDKLEVQTRHARNRLSEVSRNFHRFSEEEIRNAYEKAHKLQV ELTMIQQREKQLRERRDDLERRLLGLQEIIERSESLVSQITVVLNYLNQDLREVGLLL ADAQAKQDFGLRIIEAQEEERKRVSREIHDGPAQMLANVMMRSELIERIFRDRGAEDG FQEIKNLRQNVRNALYEVRRIIYDLRPMALDDLGLIPTLRKYLYTTEEYNGKVKIHFQ CIGETEDQRLAPQFEVALFRLAQEAVSNALKHSESEEITVKVEITKDFVILMIKDNGK GFDLKEAKEKKNKSFGLLGMKERVDLLEGTMTIDSKIGLGTFIMIKVPLSL*" /label="degS CDS" gene complement(3269702..3270859) /gene="degS" /locus_tag="BSU_35500" /old_locus_tag="BSU35500" /label="degS gene" S_feature complement(3270860..3270987) /Source="Nicolas_S_feature" /locus_tag="new_3646537_3646664_c" /HighExp="T0.30H, Lbtran, M9-stat, T3.0H, T1.0H, HiOs, T1.30H, T2.30H, T3.30H, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1356" promotor_-35 3270907..3270910 /Source="Nicolas_upshift_promotors" /id="U2780" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.656343656343656" /psig="0.999000999001" /xcortree=2533 /SigmaFactorBS="ggcgttgtcatatatttttattataaatgtaATTGatctgca aattatgTCGAATTATAATGAAAGAATgcgtatattctagaaaaaaacatttttatat a" /listShort="S1357, yvyE, yvhJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3270925..3270944 /Source="Nicolas_upshift_promotors" /id="U2780" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.656343656343656" /psig="0.999000999001" /xcortree=2533 /SigmaFactorBS="ggcgttgtcatatatttttattataaatgtaATTGatctgca aattatgTCGAATTATAATGAAAGAATgcgtatattctagaaaaaaacatttttatat a" /listShort="S1357, yvyE, yvhJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3270936..3271022 /Source="Nicolas_S_feature" /locus_tag="new_3646613_3646699" /HighExp="UNK1, Cold, C30, Lbexp, MG 15, G135, G180, G150, Paraq, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1357" upshifts 3270936 /Source="Nicolas_upshifts" /id="U2780" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.656343656343656" /psig="0.999000999001" /xcortree=2533 /SigmaFactorBS="ggcgttgtcatatatttttattataaatgtaATTGatctgca aattatgTCGAATTATAATGAAAGAATgcgtatattctagaaaaaaacatttttatat a" /listShort="S1357, yvyE, yvhJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3270981..3271000) /Source="Nicolas_upshift_promotors" /id="U2781" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.928071928071928" /psig="0.998001998001998" /xcortree=2274 /SigmaFactorBS="agactgcctatacaaattcgtacagtcttTAGAATTTttgtg cgtatTTTGGTATCATAAAGAGTAGatagtatataaaaatgtttttttctagaatata c" /listShort="S1356, degS, S1355, degU, yviA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3270987) /Source="Nicolas_upshifts" /id="U2781" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.928071928071928" /psig="0.998001998001998" /xcortree=2274 /SigmaFactorBS="agactgcctatacaaattcgtacagtcttTAGAATTTttgtg cgtatTTTGGTATCATAAAGAGTAGatagtatataaaaatgtttttttctagaatata c" /listShort="S1356, degS, S1355, degU, yviA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3271004..3271012 /Source="Nicolas_upshift_promotors" /id="U2782" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1725 /SigmaFactorBS="acatttttatatactatctactctttatgataccaaaataCG CACAAAAattctaaagactgTACGAATTTgtataggcagtcttttatgcttagcagga g" /listShort="yvyE, yvhJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(3271011..3271018) /Source="Nicolas_upshift_promotors" /id="U2781" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.928071928071928" /psig="0.998001998001998" /xcortree=2274 /SigmaFactorBS="agactgcctatacaaattcgtacagtcttTAGAATTTttgtg cgtatTTTGGTATCATAAAGAGTAGatagtatataaaaatgtttttttctagaatata c" /listShort="S1356, degS, S1355, degU, yviA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3271024 /Source="Nicolas_upshifts" /id="U2782" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1725 /SigmaFactorBS="acatttttatatactatctactctttatgataccaaaataCG CACAAAAattctaaagactgTACGAATTTgtataggcagtcttttatgcttagcagga g" /listShort="yvyE, yvhJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3271026..3271034 /Source="Nicolas_upshift_promotors" /id="U2782" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1725 /SigmaFactorBS="acatttttatatactatctactctttatgataccaaaataCG CACAAAAattctaaagactgTACGAATTTgtataggcagtcttttatgcttagcagga g" /listShort="yvyE, yvhJ" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3271076..3271729 /gene="yvyE" /locus_tag="BSU_35510" /old_locus_tag="BSU35510" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11116084, 15103642, 21239490, 22404850; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative translation regulator" /protein_id="NP_391431.1" /db_xref="EnsemblGenomes-Gn:BSU35510" /db_xref="EnsemblGenomes-Tr:CAB15568" /db_xref="InterPro:IPR001498" /db_xref="InterPro:IPR015269" /db_xref="InterPro:IPR015796" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR020569" /db_xref="InterPro:IPR023582" /db_xref="InterPro:IPR035647" /db_xref="InterPro:IPR036956" /db_xref="SubtiList:BG11052" /db_xref="UniProtKB/Swiss-Prot:P32437" /translation="MLHSYFTVKEAGEHEIVIEKSRFICHLSRVSTEQEAQEFIQKIK KQHWNATHNCSAYVIGENDHIQKANDDGEPSGTAGVPMLEVLKKRRLKDTCAVVTRYF GGIKLGAGGLIRAYGKSVSEGLNHIGVVERKLMRIMHTSADYTWLGKIENELRESQFL LKEIHYSENVEFETYVEEKETNAFSEWMTELTNGKSDIKEGELTYLEKAVNHIKETE* " /label="yvyE CDS" gene 3271076..3271729 /gene="yvyE" /locus_tag="BSU_35510" /old_locus_tag="BSU35510" /label="yvyE gene" S_feature complement(3271432..3272024) /Source="Nicolas_S_feature" /locus_tag="new_3647109_3647701_c" /HighExp="Etha, M9-stat, Gly, C30, B60, Salt, T0.30H, Sw, LoTm, S8" /AntisenseName="yvyE" /AntisenseCor="-0.139956338862644" /AntisenseRegPval="-1.7" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1358" CDS 3271729..3272904 /gene="tagV" /locus_tag="BSU_35520" /old_locus_tag="BSU35520" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:19099556, 29107701" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19099556, 29107701; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="teichoic acid-peptidoglycan tethering enzyme (LCP component) with transcription regulator domain" /protein_id="NP_391432.1" /db_xref="EnsemblGenomes-Gn:BSU35520" /db_xref="EnsemblGenomes-Tr:CAB15569" /db_xref="GOA:P96499" /db_xref="InterPro:IPR004474" /db_xref="PDB:3NXH" /db_xref="SubtiList:BG12449" /db_xref="UniProtKB/Swiss-Prot:P96499" /translation="MAERVRVRVRKKKKSKRRKILKRIMLLFALALLVVVGLGGYKLY KTINAADESYDALSRGNKSNLRNEVVDMKKKPFSILFMGIEDYATKGQKGRSDSLIVV TLDPKNKTMKMLSIPRDTRVQLAGDTTGSKTKINAAYSKGGKDETVETVENFLQIPID KYVTVDFDGFKDVINEVGGIDVDVPFDFDEKSDVDESKRIYFKKGEMHLNGEEALAYA RMRKQDKRGDFGRNDRQKQILNALIDRMSSASNIAKIDKIAEKASENVETNIRITEGL ALQQIYSGFTSKKIDTLSITGSDLYLGPNNTYYFEPDATNLEKVRKTLQEHLDYTPDT STGTSGTEDGTDSSSSSGSTGSTGTTTDGTTNGSSYSNDSSTSSNNSTTNSTTDSSY* " /label="tagV CDS" gene 3271729..3272904 /gene="tagV" /locus_tag="BSU_35520" /old_locus_tag="BSU35520" /label="tagV gene" promotor_-10 complement(3272020..3272038) /Source="Nicolas_upshift_promotors" /id="U2783" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=201 /SigmaFactorBS="gtgtgtcacgcggaatgctcagcattttcatGGTTTTAtttt tgggatccaGGGTAACAACAATAAGAGAgtctgatctccctttttgtcctttagtcgc g" /listShort="S1358" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3272029) /Source="Nicolas_upshifts" /id="U2783" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=201 /SigmaFactorBS="gtgtgtcacgcggaatgctcagcattttcatGGTTTTAtttt tgggatccaGGGTAACAACAATAAGAGAgtctgatctccctttttgtcctttagtcgc g" /listShort="S1358" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3272052..3272058) /Source="Nicolas_upshift_promotors" /id="U2783" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=201 /SigmaFactorBS="gtgtgtcacgcggaatgctcagcattttcatGGTTTTAtttt tgggatccaGGGTAACAACAATAAGAGAgtctgatctccctttttgtcctttagtcgc g" /listShort="S1358" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3272876 /Source="Nicolas_upshifts" /id="D1837" /incds=0 /nref=199 /ntot=276 /MaxReadThrough="2.38202" /MaxDrop="7.1642" /score="16.6000843" /energy="-18.6" /TU="NA" /idTUdmin="U2782" /TUdmin=4 /isTUend="TRUE" /label="downshifts" CDS complement(3272977..3274053) /gene="tagO" /locus_tag="BSU_35530" /old_locus_tag="BSU35530" /EC_number="2.7.8.33" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12101296, 12682299, 15849754, 16850406, 17012386, 18156271, 27312048" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12101296, 12682299, 15849754, 16850406, 17012386, 18156271, 27312048; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylglucosamine:undecaprenyl-P N-acetylglucosaminyl-1-P transferase" /protein_id="NP_391433.1" /db_xref="EnsemblGenomes-Gn:BSU35530" /db_xref="EnsemblGenomes-Tr:CAB15570" /db_xref="GOA:O34753" /db_xref="InterPro:IPR000715" /db_xref="InterPro:IPR018480" /db_xref="SubtiList:BG12684" /db_xref="UniProtKB/Swiss-Prot:O34753" /translation="MLDERMIRIVVAFIVSLLTVLIITPIVKRIAIKIGAVDQPSNRK VHDKIMPRMGGLAIFIGVVAGVLASGIYTETRMTAITVGAFIIIVLGILDDKYQLSAK VKFLIQLGVAIMIVSTGLKMDFFSVPFLTERFELGWMAYPLTVLWIVGITNAINLIDG LDGLAAGLSVIGLSTIAVMALSGGKVLILSLSLVVIASTLGFLFYNFHPAKIFMGDTG SLFLGYSISILSLLGLYKSVTLFSIVIPIIILGVPIFDTTFAIIRRILNKQPISAPDK SHIHHRLMAFGLSHRMSVLVIYLIGFIFSISAIVLKSATIWLSLFIIFILIIFMQIIA EVTGLVNEKFKPFTKFYKRLVKRN*" /label="tagO CDS" gene complement(3272977..3274053) /gene="tagO" /locus_tag="BSU_35530" /old_locus_tag="BSU35530" /label="tagO gene" downshifts complement(3272993) /Source="Nicolas_upshifts" /id="D1838" /incds=0 /nref=221 /ntot=280 /MaxReadThrough="1.7614" /MaxDrop="8.41647" /score="29.109706" /energy="-11.6" /TU="NA" /idTUdmin="U2785" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 3273039..3273048 /Source="Nicolas_upshift_promotors" /id="U2784" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1388 /SigmaFactorBS="tgtaaacggcttaaatttttcattcacgaGTCCTGTCACttc tgctatgattTGCATAAAAATAATCAAAATgaagataataaacaaagaaagccaaatt g" /listShort="S1359" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3273062..3273081 /Source="Nicolas_upshift_promotors" /id="U2784" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1388 /SigmaFactorBS="tgtaaacggcttaaatttttcattcacgaGTCCTGTCACttc tgctatgattTGCATAAAAATAATCAAAATgaagataataaacaaagaaagccaaatt g" /listShort="S1359" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3273070..3274303 /Source="Nicolas_S_feature" /locus_tag="new_3648747_3649980" /HighExp="S8, S6, S7, S5, BT, S4, B36, Pyr, S3, G/S" /AntisenseName="tagO" /AntisenseCor="-0.60515751332040901" /AntisenseRegPval="-27.5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1359" upshifts 3273070 /Source="Nicolas_upshifts" /id="U2784" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1388 /SigmaFactorBS="tgtaaacggcttaaatttttcattcacgaGTCCTGTCACttc tgctatgattTGCATAAAAATAATCAAAATgaagataataaacaaagaaagccaaatt g" /listShort="S1359" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3274054..3274136) /Source="Nicolas_S_feature" /locus_tag="new_3649731_3649813_c" /HighExp="LPhT, Cold, LoTm, T0.30H, T3.0H, LBGstat, T1.30H, T1.0H, T2.30H, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.67123699999999997" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0.018" /TUlongSig="NA" /TUlongPSig="NA" /label="S1360" promotor_-10 complement(3274124..3274143) /Source="Nicolas_upshift_promotors" /id="U2785" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.856143856143856" /psig=1 /xcortree=2139 /SigmaFactorBS="cctataaattgggatgcgcgttttttgattatacgTGTTTCT ttttgatgaagCTTGTTATAATAACTAAGGAgaaggtataatggaaggaacggttctc t" /listShort="S1360, tagO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3274136) /Source="Nicolas_upshifts" /id="U2785" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.856143856143856" /psig=1 /xcortree=2139 /SigmaFactorBS="cctataaattgggatgcgcgttttttgattatacgTGTTTCT ttttgatgaagCTTGTTATAATAACTAAGGAgaaggtataatggaaggaacggttctc t" /listShort="S1360, tagO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3274155..3274161) /Source="Nicolas_upshift_promotors" /id="U2785" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.856143856143856" /psig=1 /xcortree=2139 /SigmaFactorBS="cctataaattgggatgcgcgttttttgattatacgTGTTTCT ttttgatgaagCTTGTTATAATAACTAAGGAgaaggtataatggaaggaacggttctc t" /listShort="S1360, tagO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3274198..3275391) /gene="tuaH" /locus_tag="BSU_35540" /old_locus_tag="BSU35540" /EC_number="2.4.1.-" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 4975313, 10048024, 11994144, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase (teichuronic acid)" /protein_id="NP_391434.1" /db_xref="EnsemblGenomes-Gn:BSU35540" /db_xref="EnsemblGenomes-Tr:CAB15571" /db_xref="GOA:O32267" /db_xref="SubtiList:BG12695" /db_xref="UniProtKB/Swiss-Prot:O32267" /translation="METKEAIIHVIVATAEWGKDQLRYRRHRLAEFLAAQEETKEVIW VCPAPRAQGKEFQEVHSGIRQFAVKDLLQKKMFRFGRYTDVFYRHKLSPLLDELTPAS ANGERCCLWYTFPGFPLLSSLYSWDQVIYDCSDLWAAPISGRSNLLSEFRRKVIKSAE LRIIQRADSITCSSDYLHKEVDKKLTAGREKVHTVENGVEYELFSANKQAPDRSILQG REGIVLGFIGGIKPKLDFKMIKEAALQKPDWTFLWVGPDATNGDVSFQELLRLPNVIW TGPADPKEVPHYMELIDIGIMPYKQSPYNQAVFPLKLFEFLAAGKPVVGTNLPSTSKM QKPYVYEYVEGDHPIDFIAACEKVLGQNGDETYKEMRRNIARTQDWNCLFRQIMKYTG IQKHA*" /label="tuaH CDS" gene complement(3274198..3275391) /gene="tuaH" /locus_tag="BSU_35540" /old_locus_tag="BSU35540" /label="tuaH gene" downshifts complement(3274228) /Source="Nicolas_upshifts" /id="D1839" /incds=0 /nref=23 /ntot=141 /MaxReadThrough="7.20583" /MaxDrop="4.88676" /score="4.72365619" /energy="-10.8" /TU="U2786" /idTUdmin="U2785" /TUdmin="-1236" /isTUend="FALSE" /label="downshifts" CDS complement(3275420..3276178) /gene="tuaG" /locus_tag="BSU_35550" /old_locus_tag="BSU35550" /EC_number="2.4.1.-" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 4975313, 10048024, 11994144, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase (teichuronic acid)" /protein_id="NP_391435.1" /db_xref="EnsemblGenomes-Gn:BSU35550" /db_xref="EnsemblGenomes-Tr:CAB15572" /db_xref="GOA:O32268" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG12694" /db_xref="UniProtKB/Swiss-Prot:O32268" /translation="MTNWKPLVSVITPSYNARDYIEDTVHSVLDQSHPHWEMIIVDDC STDGTRDILQQYEKIDERIHVVYLEENSGAAVARNKALERAQGRYVAFLDSDDKWKKD KLEKQLEFMMERSCAFSFTGYSLMAQDGTPLDKFIHAPESLTYDDALKNTIIGCLTVM IDREQTGQIQMPNIRTRQDLATWLSLLKKGFTAYGMNECLAEYRLVNNSISSNKWKAA KKTWFVYREIERLHFMKATWCFVQYAKNAVKKRL*" /label="tuaG CDS" gene complement(3275420..3276178) /gene="tuaG" /locus_tag="BSU_35550" /old_locus_tag="BSU35550" /label="tuaG gene" CDS complement(3276202..3276882) /gene="tuaF" /locus_tag="BSU_35560" /old_locus_tag="BSU35560" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 4975313, 10048024, 11994144, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase involved in teichuronic acid synthesis" /protein_id="NP_391436.1" /db_xref="EnsemblGenomes-Gn:BSU35560" /db_xref="EnsemblGenomes-Tr:CAB15573" /db_xref="GOA:O32269" /db_xref="InterPro:IPR003856" /db_xref="SubtiList:BG12693" /db_xref="UniProtKB/Swiss-Prot:O32269" /translation="MNDILIRIARRIKKNIIWIIAVPIILGAAGYILPSQIADQKSYT AEDTLAVGSYDHPVYNSTEEIPLLLKSDSFLKEALPDEKDEDVAEIKEKLTINTESKS LLTLSYSDEDKDRTESVLNAISSTFLKNDQKLYAEREAVIRSSIDALEGESVSEDSKV DKERFLYELKNTQLNLKAASVTDSETVSETAGGGMSPKKKAVLGVMIGLTIAFMFVVI PEFFRESF*" /label="tuaF CDS" gene complement(3276202..3276882) /gene="tuaF" /locus_tag="BSU_35560" /old_locus_tag="BSU35560" /label="tuaF gene" CDS complement(3276911..3278377) /gene="tuaE" /locus_tag="BSU_35570" /old_locus_tag="BSU35570" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 4975313, 10048024, 11994144, 15849754, 16850406, 26284661; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="putative polymerase of teichuronic acid repeating units" /protein_id="NP_391437.1" /db_xref="EnsemblGenomes-Gn:BSU35570" /db_xref="EnsemblGenomes-Tr:CAB15574" /db_xref="GOA:O32270" /db_xref="InterPro:IPR007016" /db_xref="SubtiList:BG12692" /db_xref="UniProtKB/Swiss-Prot:O32270" /translation="MSIKRSAVHTLALLAAAIFGVVLLLGAIHKDIGFMQMAAVLAVL AIGLFLLTLATAFTTKERLFMAVIYILIACTFLNNAFFAIHLGFFSLFLYRLLLIAAG CLHIFGMVRNRTHIERWHGLQVKGILLFFAFWFIYGLVSLLWAKSVTVGLKYLALLAM GIFFIYLIVMYVQKMERLMIVYAIWLVMTVFLMIIGFYNHITHHHLASSTLYSGPEYK QHYPTSVFFNQNDFATFLSISFFFYITMMKNIKNGYIKAIGLVLSLCALYLIFATGSR ASLLGIFAGIAVYIFIVLPPVLKRMAIWLSAAGIALFAVLFASKIYSKFWELFLAPQT LHSFHDRLPSNVARANLLKNAWHFFLDSYGFGVGAGNVSYYLEHYAVYDTDNVAEVHN WLVEILANFGLFIMLGYLSVYAYLIWVLYKFYERKLENQSKLITEGLITAMVSFLVSS ISPSSVSNLFFHWVFMALVIAAVNVLRRSRQMPEPMYR*" /label="tuaE CDS" gene complement(3276911..3278377) /gene="tuaE" /locus_tag="BSU_35570" /old_locus_tag="BSU35570" /label="tuaE gene" S_feature complement(3278378..3278461) /Source="Nicolas_S_feature" /locus_tag="new_3654055_3654138_c" /HighExp="LPhT, S3, B60, S7, S4, S6, LBGstat, BI, S8, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.018" /TUlongSig="NA" /TUlongPSig="NA" /label="S1361" CDS complement(3278462..3279847) /gene="tuaD" /locus_tag="BSU_35580" /old_locus_tag="BSU35580" /EC_number="1.1.1.22" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10376820, 10913081, 12970183, 16000785, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10376820, 10913081, 12970183, 16000785, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-glucose 6-dehydrogenase (teichuronic acid)" /protein_id="NP_391438.1" /db_xref="EnsemblGenomes-Gn:BSU35580" /db_xref="EnsemblGenomes-Tr:CAB15575" /db_xref="GOA:O32271" /db_xref="InterPro:IPR001732" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR014026" /db_xref="InterPro:IPR014027" /db_xref="InterPro:IPR017476" /db_xref="InterPro:IPR021157" /db_xref="InterPro:IPR028357" /db_xref="InterPro:IPR036220" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12691" /db_xref="UniProtKB/Swiss-Prot:O32271" /translation="MKKIAVIGTGYVGLVSGTCFAEIGNKVVCCDIDESKIRSLKNGV IPIYEPGLADLVEKNVLDQRLTFTNDIPSAIRASDIIYIAVGTPMSKTGEADLTYVKA AAKTIGEHLNGYKVIVNKSTVPVGTGKLVQSIVQKASKGRYSFDVVSNPEFLREGSAI HDTMNMERAVIGSTSHKAAAIIEELHQPFHAPVIKTNLESAEMIKYAANAFLATKISF INDIANICERVGADVSKVADGVGLDSRIGRKFLKAGIGFGGSCFPKDTTALLQIAKSA GYPFKLIEAVIETNEKQRVHIVDKLLTVMGSVKGRTISVLGLAFKPNTNDVRSAPALD IIPMLQQLGAHVKAYDPIAIPEASAILGEQVEYYTDVYAAMEDTDACLILTDWPEVKE MELVKVKTLLKQPVIIDGRNLFSLEEMQAAGYIYHSIGRPAVRGTEPSDKYFPGLPLE ELAKDLGSVNL*" /label="tuaD CDS" gene complement(3278462..3279847) /gene="tuaD" /locus_tag="BSU_35580" /old_locus_tag="BSU35580" /label="tuaD gene" CDS complement(3279909..3281078) /gene="tuaC" /locus_tag="BSU_35590" /old_locus_tag="BSU35590" /EC_number="2.4.1.-" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 4975313, 10048024, 11994144, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase (teichuronic acid)" /protein_id="NP_391439.1" /db_xref="EnsemblGenomes-Gn:BSU35590" /db_xref="EnsemblGenomes-Tr:CAB15576" /db_xref="GOA:O32272" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR028098" /db_xref="SubtiList:BG12690" /db_xref="UniProtKB/Swiss-Prot:O32272" /translation="MKILWITSVYPSSMKPGEGVFHETQVQELQKLGLDITVICPRPF HSAPVRMLKKTYRKKDVRPEYEIRKGIPVYRPFYRAVPGQLKWAQPHRRIASAVLKTM KQRDLYPDLIHAHFAMPSGGAAAVVSESAQIPYVLTLHGSDVNVYPHYSKGAFKAFKR AVGSASVVLAVSHKLQEEAKKLSGFDSSVLPIGIQLSRFQGNEETKEEIRKRLGLPLD QRLAVYVGRLVREKGIFELSEAIESLQDSPKAVFVGDGPAKSTLTQKGHIVTGQVPNH QVRDYLLAADLFVLPSYSEGMPTVVIEALALRVPVICTDVGGVSSLFGKHQHLLIKPK SAQALAEAITRYEHEQIWKPEVADDLYETVQAQFDAGKNAKALHHQYQTVTKTSV*" /label="tuaC CDS" gene complement(3279909..3281078) /gene="tuaC" /locus_tag="BSU_35590" /old_locus_tag="BSU35590" /label="tuaC gene" CDS complement(3281075..3282526) /gene="tuaB" /locus_tag="BSU_35600" /old_locus_tag="BSU35600" /function="16.8: Protect" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10048024, 11994144, 15849754, 16850406, 22720735, 26284661; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative exporter involved in biosynthesis of teichuronic acid" /protein_id="NP_391440.1" /db_xref="EnsemblGenomes-Gn:BSU35600" /db_xref="EnsemblGenomes-Tr:CAB15577" /db_xref="GOA:O32273" /db_xref="InterPro:IPR002797" /db_xref="InterPro:IPR029303" /db_xref="SubtiList:BG12689" /db_xref="UniProtKB/Swiss-Prot:O32273" /translation="MPSITKQIMSGAKWTSISTMCITIIQIVQFALLGNMMTLTEFGL VGMITTVTVFAQIVLDMGFGAALIQRDDATERQLSTLYWLNIMTGVLLFVLLYVSSPV IAGFYQREELVFLVRILAIMFLIAPIGQQYQYMLQKQLHFNTLSKIEIFSNVLSFGYL AIAVFMMDAILAYVISQVLLQSSKGILYWAVYRKKWHPAFVFDLRGMKDFFSFGAFQL SSRLVNRLGANIDMILIGRFIGAEALGIYNLAYQIVTIPVLKINPIVTRVAFPIFAKN KYENSVIREGFLNMTKMLALVSFPLLIGLVSVSDAFITAVFGEKWLAAVPILNVLAIV GILRVLMNPNGSVLLAKGRADLAFYWDSGVLLLYGLSLFAAVQTGSLLTVAWVYAIIS VVNFLIGRWLLAYVIKLNLSAYFQSIMKPFLITAAMGIIAFGVSLSTEHFSMQAEMRL AISVAAGALCYLFLLVKAYPQTKSKLLRKGRLS*" /label="tuaB CDS" gene complement(3281075..3282526) /gene="tuaB" /locus_tag="BSU_35600" /old_locus_tag="BSU35600" /label="tuaB gene" CDS complement(3282582..3282731) /gene="tuaAc" /locus_tag="BSU_35609" /old_locus_tag="BSU35609" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId: 7704262, 26284661; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative undecaprenyl-phosphate N-acetylgalactosaminyl-1-phosphate transferase; C-terminal part of TuaA" /db_xref="SubtiList:BG12688" /translation="WAQVNGGYDMTPKEKLIFDLYYIRNLTFTLELKIMLKTCKVVWT GDGAR*" /label="tuaAc CDS" gene complement(3282582..3282731) /gene="tuaAc" /locus_tag="BSU_35609" /old_locus_tag="BSU35609" /pseudo /label="tuaAc gene" CDS complement(3282676..3283215) /gene="tuaAn" /locus_tag="BSU_35610" /old_locus_tag="BSU35610" /EC_number="2.7.8.-" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 10048024, 11994144, 26284661; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative undecaprenyl-phosphate N-acetylgalactosaminyl-1-phosphate transferase; N-terminal part of TuaA" /translation="MSAEKSMNVSREFSVQQIHSFTLSEKTARYLAIKRVMDIWFALI GLAIALPMIAVFSILICLETPGPAIYTQERVGKGGKPFKLYKLRSMKIDAEKSGAVWA QKQDPRVTRIGAFIRRTRIDELPQLFNVLKGDMSMIGPRPERPVFTEKFQNEIPGFTQ RLGSGERRLRYDAEGKADI*" /label="tuaAn CDS" gene complement(3282676..3283215) /gene="tuaAn" /locus_tag="BSU_35610" /old_locus_tag="BSU35610" /pseudo /label="tuaAn gene" misc_feature complement(3283271..3283288) /Source="Nicolas_upshift_promotors" /id="U2786" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.017982017982018" /xcortree=12 /SigmaFactorBS="cagaaaaaacacgtaattcacacttcttaacataccatttac atccaATTAACATCCGTCTGCTAaactgactggcataggtcatcataacatcccaaac a" /listShort="tuaA, tuaA, tuaB, tuaC, tuaD, S1361, tuaE, tuaF, tuaG, tuaH, S1360, tagO" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3283275) /Source="Nicolas_upshifts" /id="U2786" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.017982017982018" /xcortree=12 /SigmaFactorBS="cagaaaaaacacgtaattcacacttcttaacataccatttac atccaATTAACATCCGTCTGCTAaactgactggcataggtcatcataacatcccaaac a" /listShort="tuaA, tuaA, tuaB, tuaC, tuaD, S1361, tuaE, tuaF, tuaG, tuaH, S1360, tagO" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3283442..3284932) /gene="lytC" /locus_tag="BSU_35620" /old_locus_tag="BSU35620" /EC_number="3.5.1.28" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:1357079, 9537764, 14594841, 17298895, 19542270, 22469514" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1357079, 9537764, 14594841, 17298895, 19542270, 22469514; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="N-acetylmuramoyl-L-alanine amidase (major autolysin)" /protein_id="NP_391442.1" /db_xref="EnsemblGenomes-Gn:BSU35620" /db_xref="EnsemblGenomes-Tr:CAB15579" /db_xref="GOA:Q02114" /db_xref="InterPro:IPR002508" /db_xref="InterPro:IPR007253" /db_xref="SubtiList:BG10407" /db_xref="UniProtKB/Swiss-Prot:Q02114" /translation="MRSYIKVLTMCFLGLILFVPTALADNSVKRVGGSNRYGTAVQIS KQMYSTASTAVIVGGSSYADAISAAPLAYQKNAPLLYTNSDKLSYETKTRLKEMQTKN VIIVGGTPAVSSNTANQIKSLGISIKRIAGSNRYDTAARVAKAMGATSKAVILNGFLY ADAPAVIPYAAKNGYPILFTNKTSINSATTSVIKDKGISSTVVVGGTGSISNTVYNKL PSPTRISGSNRYELAANIVQKLNLSTSTVYVSNGFSYPDSIAGATLAAKKKQSLILTN GENLSTGARKIIGSKNMSNFMIIGNTPAVSTKVANQLKNPVVGETIFIDPGHGDQDSG AIGNGLLEKEVNLDIAKRVNTKLNASGALPVLSRSNDTFYSLQERVNKAASAQADLFL SIHANANDSSSPNGSETYYDTTYQAANSKRLAEQIQPKLAANLGTRDRGVKTAAFYVI KYSKMPSVLVETAFITNASDASKLKQAVYKDKAAQAIHDGTVSYYR*" /label="lytC CDS" gene complement(3283442..3284932) /gene="lytC" /locus_tag="BSU_35620" /old_locus_tag="BSU35620" /label="lytC gene" downshifts complement(3283464) /Source="Nicolas_upshifts" /id="D1840" /incds=0 /nref=145 /ntot=213 /MaxReadThrough="3.26689" /MaxDrop="6.50948" /score="13.9455176" /energy="-13.3" /TU="NA" /idTUdmin="U2788" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3284971..3287088) /gene="lytB" /locus_tag="BSU_35630" /old_locus_tag="BSU35630" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /function="16.13: Shape" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1357079, 16306698, 17269748" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1357079, 16306698, 17269748; Product type r: regulator" /codon_start=1 /transl_table=11 /product="modifier of major autolysin amidase LytC" /protein_id="NP_391443.1" /db_xref="EnsemblGenomes-Gn:BSU35630" /db_xref="EnsemblGenomes-Tr:CAB15580" /db_xref="GOA:Q02113" /db_xref="InterPro:IPR007253" /db_xref="InterPro:IPR013486" /db_xref="InterPro:IPR013693" /db_xref="SubtiList:BG10406" /db_xref="UniProtKB/Swiss-Prot:Q02113" /translation="MKSCKQLIVCSLAAILLLIPSVSFAADSNISVKLLNYIGNKSSI SLSPTGFYKVTGDNVAVTDRFAGASRYETATLASNSQWKNPNTVILVNRDIFIDALPV IPLAKKLNAPVLFTQPDTLTKTTERQIAKFNPDNILIIGGARSISKDVENKLKSYGAV KRISGKNRYVLSENIAKQMGSYDKAIVVTGRVFQDALAIAPYAAAHGYPILLTEKDKL PDYDLPKQVIIIGSSFSVSDSVENQIKKTSTVQRIPGSTRYELTANIIKQLKLKADKV VMTNGTKYADVLIGASLASKKNSQILFVKQDSVPAAAKSITKDKATYAYDFIGSTSSI SAEVENSLADEFYLADGGTYNLKINSGKLNLENIKTYGNSLRIKPENYSTSNRISLDG KQYLGTVNFSIESTKYIRPVNENIPFEDYLKGVIPNEMPASWSLEALKAQTVAARTYS ITKTGTTVPDTTAFQVYGGYSWNSNTNKAVEQTKGKVLKYNGSLITAAYSSSNGGYTE ASNEVWSSSVPYLIAKKDTKDPQIGWTLTLSKQQLDTKSLDLTKPSSWWSSATETDSA RLSGVKNWILKNKETSADSVKIASIDDLSFSGTTQGQRAKTASMKVKYFVKSSTGSYN LSKITTISVPTSELRTMIGATVFKSTYVTVKKDTSKYTISGKGYGHGIGMSQYGAKAR AEAGDSYSSILKFYYPGTTLTSY*" /label="lytB CDS" gene complement(3284971..3287088) /gene="lytB" /locus_tag="BSU_35630" /old_locus_tag="BSU35630" /label="lytB gene" CDS complement(3287112..3287420) /gene="lytA" /locus_tag="BSU_35640" /old_locus_tag="BSU35640" /function="16.13: Shape" /function="16.11: Scavenge (Catabolism)" /function="16.1: Circulate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:1357079, 10974124, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1357079, 10974124, 22720735; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="membrane bound lipoprotein" /protein_id="NP_391444.1" /db_xref="EnsemblGenomes-Gn:BSU35640" /db_xref="EnsemblGenomes-Tr:CAB15581" /db_xref="GOA:Q02112" /db_xref="SubtiList:BG10405" /db_xref="UniProtKB/Swiss-Prot:Q02112" /translation="MKKFIALLFFILLLSGCGVNSQKSQGEDVSPDSNIETKEGTYVG LADTHTIEVTVDNEPVSLDITEESTSDLDKFNSGDKVTITYEKNDEGQLLLKDIERAN *" /label="lytA CDS" gene complement(3287112..3287420) /gene="lytA" /locus_tag="BSU_35640" /old_locus_tag="BSU35640" /label="lytA gene" downshifts 3287326 /Source="Nicolas_upshifts" /id="D1841" /incds=1 /nref=1 /ntot=45 /MaxReadThrough="1.03108" /MaxDrop="2.46089" /score="-4.93783022" /energy="-8" /TU="NA" /idTUdmin="U2787" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" promotor_-35 3287416..3287420 /Source="Nicolas_upshift_promotors" /id="U2787" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.998001998001998" /psig=0 /xcortree=300 /SigmaFactorBS="cgaaagaagcaatataaagaacagtaaagcaataaattttTT CATttttttcaCCTCATTATATTTTAtcgtcaacctattttatattttaaagaaaaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3287429..3287443 /Source="Nicolas_upshift_promotors" /id="U2787" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.998001998001998" /psig=0 /xcortree=300 /SigmaFactorBS="cgaaagaagcaatataaagaacagtaaagcaataaattttTT CATttttttcaCCTCATTATATTTTAtcgtcaacctattttatattttaaagaaaaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(3287430..3287448) /Source="Nicolas_upshift_promotors" /id="U2788" /multdbtbs="SigA,SigD" /comp="M10" /sig="SigD" /pcomp="0.925074925074925" /psig="0.925074925074925" /xcortree=2795 /SigmaFactorBS="gaaatcctaaaatagtcgttttttataaaaaaaagtttcatt gtttcttaatttttCTTTAAAAtataaaataggttGACGATAAAATATAATGAGgtga a" /listShort="lytA, lytB, lytC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3287436 /Source="Nicolas_upshifts" /id="U2787" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.998001998001998" /psig=0 /xcortree=300 /SigmaFactorBS="cgaaagaagcaatataaagaacagtaaagcaataaattttTT CATttttttcaCCTCATTATATTTTAtcgtcaacctattttatattttaaagaaaaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3287462..3287469) /Source="Nicolas_upshift_promotors" /id="U2788" /multdbtbs="SigA,SigD" /comp="M10" /sig="SigD" /pcomp="0.925074925074925" /psig="0.925074925074925" /xcortree=2795 /SigmaFactorBS="gaaatcctaaaatagtcgttttttataaaaaaaagtttcatt gtttcttaatttttCTTTAAAAtataaaataggttGACGATAAAATATAATGAGgtga a" /listShort="lytA, lytB, lytC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3287465) /Source="Nicolas_upshifts" /id="U2788" /multdbtbs="SigA,SigD" /comp="M10" /sig="SigD" /pcomp="0.925074925074925" /psig="0.925074925074925" /xcortree=2795 /SigmaFactorBS="gaaatcctaaaatagtcgttttttataaaaaaaagtttcatt gtttcttaatttttCTTTAAAAtataaaataggttGACGATAAAATATAATGAGgtga a" /listShort="lytA, lytB, lytC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3287486..3287494 /Source="Nicolas_upshift_promotors" /id="U2789" /multdbtbs="SigX" /comp="M9" /sig="SigWXY" /pcomp="0.584415584415584" /psig="0.584415584415584" /xcortree=2152 /SigmaFactorBS="aaagaaaaattaagaaacaaTGAAACTTTtttttataaaaaa CGACTATTTTAGGAtttcattcttgtattaaatagagttgtatttattggaaatttaa c" /listShort="lytR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3287508..3287521 /Source="Nicolas_upshift_promotors" /id="U2789" /multdbtbs="SigX" /comp="M9" /sig="SigWXY" /pcomp="0.584415584415584" /psig="0.584415584415584" /xcortree=2152 /SigmaFactorBS="aaagaaaaattaagaaacaaTGAAACTTTtttttataaaaaa CGACTATTTTAGGAtttcattcttgtattaaatagagttgtatttattggaaatttaa c" /listShort="lytR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3287526 /Source="Nicolas_upshifts" /id="U2789" /multdbtbs="SigX" /comp="M9" /sig="SigWXY" /pcomp="0.584415584415584" /psig="0.584415584415584" /xcortree=2152 /SigmaFactorBS="aaagaaaaattaagaaacaaTGAAACTTTtttttataaaaaa CGACTATTTTAGGAtttcattcttgtattaaatagagttgtatttattggaaatttaa c" /listShort="lytR" /GFF_Attribute="listLong" /label="upshifts" CDS 3287604..3288524 /gene="tagU" /locus_tag="BSU_35650" /old_locus_tag="BSU35650" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1357079, 9636707, 12034833, 19099556, 28197687, 29107701" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1357079, 9636707, 12034833, 19099556, 28197687, 29107701; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="teichoic acid-peptidoglycan tethering enzyme (LCP component) with transcription regulator domain of major autolysin expression" /protein_id="NP_391445.1" /db_xref="EnsemblGenomes-Gn:BSU35650" /db_xref="EnsemblGenomes-Tr:CAB15582" /db_xref="GOA:Q02115" /db_xref="InterPro:IPR004474" /db_xref="InterPro:IPR023734" /db_xref="SubtiList:BG10404" /db_xref="UniProtKB/Swiss-Prot:Q02115" /translation="MRNERRKKKKTLLLTILTIIGLLVLGTGGYAYYLWHKAASTVAS IHESIDKSKKRDKEVSINKKDPFSVLIMGVDERDGDKGRADTLIYMTVNPKTNTTDMV SIPRDTYTKIIGKGTMDKINHSYAFGGTQMTVDTVENFLDVPVDYFVKVNMESFRDVV DTLGGITVNSTFAFSYDGYSFGKGEITLNGKEALAYTRMRKEDPRGDFGRQDRQRQVI QGIINKGANISSITKFGDMFKVVENNVKTNLTFDNMWDIQSDYKGARKHIKQHELKGT GTKINGIYYYQADESALSDITKELKESLEK*" /label="tagU CDS" gene 3287604..3288524 /gene="tagU" /locus_tag="BSU_35650" /old_locus_tag="BSU35650" /label="tagU gene" downshifts 3288514 /Source="Nicolas_upshifts" /id="D1842" /incds=0 /nref=224 /ntot=261 /MaxReadThrough="0.434639999999999" /MaxDrop="6.11301" /score="-4.93783022" /energy="-8" /TU="NA" /idTUdmin="U2789" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3288564..3289706) /gene="mnaA" /locus_tag="BSU_35660" /old_locus_tag="BSU35660" /EC_number="5.1.3.14" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12107153, 16952950" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12107153, 16952950; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylmannosamine 2-epimerase" /protein_id="NP_391446.1" /db_xref="EnsemblGenomes-Gn:BSU35660" /db_xref="EnsemblGenomes-Tr:CAB15583" /db_xref="GOA:P39131" /db_xref="InterPro:IPR003331" /db_xref="InterPro:IPR029767" /db_xref="PDB:1O6C" /db_xref="PDB:4FKZ" /db_xref="SubtiList:BG10403" /db_xref="UniProtKB/Swiss-Prot:P39131" /translation="MKKLKVMTVFGTRPEAIKMAPLVLELKKYPEIDSYVTVTAQHRQ MLDQVLDAFHIKPDFDLNIMKERQTLAEITSNALVRLDELFKDIKPDIVLVHGDTTTT FAGSLAAFYHQIAVGHVEAGLRTGNKYSPFPEELNRQMTGAIADLHFAPTGQAKDNLL KENKKADSIFVTGNTAIDALNTTVRDGYSHPVLDQVGEDKMILLTAHRRENLGEPMEN MFKAIRRIVGEFEDVQVVYPVHLNPVVREAAHKHFGDSDRVHLIEPLEVIDFHNFAAK SHFILTDSGGVQEEAPSLGKPVLVLRDTTERPEGVEAGTLKLAGTDEENIYQLAKQLL TDPDEYKKMSQASNPYGDGEASRRIVEELLFHYGYRKEQPDSFTGK*" /label="mnaA CDS" gene complement(3288564..3289706) /gene="mnaA" /locus_tag="BSU_35660" /old_locus_tag="BSU35660" /label="mnaA gene" downshifts complement(3288588) /Source="Nicolas_upshifts" /id="D1843" /incds=0 /nref=126 /ntot=236 /MaxReadThrough="0.41249" /MaxDrop="5.56107" /score="7.64930656" /energy="-11" /TU="NA" /idTUdmin="U2790" /TUdmin="-20" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3289745..3289764) /Source="Nicolas_upshift_promotors" /id="U2790" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=1891 /SigmaFactorBS="aaaacttatatcattttatttgaatcaagaatgaaatGATTt aaaatgatgcattTTCATGTAGAATATGTAGTAtgaatttatttactatagcagaaaa c" /listShort="mnaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3289759) /Source="Nicolas_upshifts" /id="U2790" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=1891 /SigmaFactorBS="aaaacttatatcattttatttgaatcaagaatgaaatGATTt aaaatgatgcattTTCATGTAGAATATGTAGTAtgaatttatttactatagcagaaaa c" /listShort="mnaA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3289779..3289782) /Source="Nicolas_upshift_promotors" /id="U2790" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=1891 /SigmaFactorBS="aaaacttatatcattttatttgaatcaagaatgaaatGATTt aaaatgatgcattTTCATGTAGAATATGTAGTAtgaatttatttactatagcagaaaa c" /listShort="mnaA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3289835..3289839 /Source="Nicolas_upshift_promotors" /id="U2791" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.494505494505495" /psig="0.998001998001998" /xcortree=96 /SigmaFactorBS="tcaaataaaatgatataagttttaatattaaggataaaGCTT GtttaaaaatggtttaTCCGATATCATAAAAATGTGtaaaaacatattgaaaagggta a" /listShort="S1362, gtaB, S1363" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3289855..3289874 /Source="Nicolas_upshift_promotors" /id="U2791" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.494505494505495" /psig="0.998001998001998" /xcortree=96 /SigmaFactorBS="tcaaataaaatgatataagttttaatattaaggataaaGCTT GtttaaaaatggtttaTCCGATATCATAAAAATGTGtaaaaacatattgaaaagggta a" /listShort="S1362, gtaB, S1363" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3289856..3289951 /Source="Nicolas_S_feature" /locus_tag="new_3665533_3665628" /HighExp="C90, dia5, Salt, Lbexp, T1.0H, MG 5, GM 90, MG 45, LoTm, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1362" upshifts 3289857 /Source="Nicolas_upshifts" /id="U2791" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.494505494505495" /psig="0.998001998001998" /xcortree=96 /SigmaFactorBS="tcaaataaaatgatataagttttaatattaaggataaaGCTT GtttaaaaatggtttaTCCGATATCATAAAAATGTGtaaaaacatattgaaaagggta a" /listShort="S1362, gtaB, S1363" /GFF_Attribute="listLong" /label="upshifts" CDS 3289952..3290830 /gene="gtaB" /locus_tag="BSU_35670" /old_locus_tag="BSU35670" /EC_number="2.7.7.9" /function="16.8: Protect" /function="16.13: Shape" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:2846750, 8126437, 8320212, 9658024, 17662947, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2846750, 8126437, 8320212, 9658024, 17662947, 26735940; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="UTP-glucose-1-phosphate uridylyltransferase" /protein_id="NP_391447.1" /db_xref="EnsemblGenomes-Gn:BSU35670" /db_xref="EnsemblGenomes-Tr:CAB15584" /db_xref="GOA:Q05852" /db_xref="InterPro:IPR005771" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10402" /db_xref="UniProtKB/Swiss-Prot:Q05852" /translation="MKKVRKAIIPAAGLGTRFLPATKAMPKEMLPIVDKPTIQYIIEE AVEAGIEDIIIVTGKSKRAIEDHFDYSPELERNLEEKGKTELLEKVKKASNLADIHYI RQKEPKGLGHAVWCARNFIGDEPFAVLLGDDIVQAETPGLRQLMDEYEKTLSSIIGVQ QVPEEETHRYGIIDPLTSEGRRYQVKNFVEKPPKGTAPSNLAILGRYVFTPEIFMYLE EQQVGAGGEIQLTDAIQKLNEIQRVFAYDFEGKRYDVGEKLGFITTTLEFAMQDKELR DQLVPFMEGLLNKEEI*" /label="gtaB CDS" gene 3289952..3290830 /gene="gtaB" /locus_tag="BSU_35670" /old_locus_tag="BSU35670" /label="gtaB gene" S_feature 3290831..3291922 /Source="Nicolas_S_feature" /locus_tag="new_3666508_3667599" /HighExp="Etha, Gly, C30, M9-stat, B60, T1.30H, B36, T1.0H, M40t90, T0.30H" /AntisenseName="yvzH" /AntisenseCor="-0.24043295548020899" /AntisenseRegPval="-4.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1363" S_feature complement(3290900..3291255) /Source="Nicolas_S_feature" /locus_tag="new_3666577_3666932_c" /HighExp="C30, LPh, HPh, Gly, G135, HiOs, aero, GM 25, MG 25, GM-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.74940200000000001" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigD" /TUlongPSig="0.996" /label="S1364" CDS 3291164..3291382 /locus_tag="BSU_35678" /old_locus_tag="BSU35678" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId: 7704262" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514004.1" /translation="MATILIPLTTLLDLSRIVGLIENHGIKPASIQTIKGTSPIPVMT SLLLRIPNTNQYAIIRIRGFKTCHNTPK*" /label="hypothetical protein CDS" gene 3291164..3291382 /locus_tag="BSU_35678" /old_locus_tag="BSU35678" /label="gene" CDS complement(3291256..3291339) /gene="yvzH" /locus_tag="BSU_35679" /old_locus_tag="BSU35679" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId: 7704262; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative teichoic acid translocation permease protein tagG (fragment)" /db_xref="PSEUDO:CAX52700.1" /translation="MMAYWFVFGMRNSKLVITGIGEVPFIV*" /label="yvzH CDS" gene complement(3291256..3291339) /gene="yvzH" /locus_tag="BSU_35679" /old_locus_tag="BSU35679" /pseudo /label="yvzH gene" S_feature complement(3291340..3291531) /Source="Nicolas_S_feature" /locus_tag="new_3667017_3667208_c" /HighExp="HPh, LPh, C30, Gly, S0, HiOs, aero, G135, Mal, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD" /TUshortPSig="1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1365" CDS complement(3291532..3294234) /gene="ggaB" /locus_tag="BSU_35680" /old_locus_tag="BSU35680" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16735734" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16735734; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="poly(glucosyl N-acetylgalactosamine 1-phosphate)glucosyltransferase" /protein_id="NP_391448.1" /db_xref="EnsemblGenomes-Gn:BSU35680" /db_xref="EnsemblGenomes-Tr:CAB15585" /db_xref="GOA:P46918" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR007554" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG11192" /db_xref="UniProtKB/Swiss-Prot:P46918" /translation="MNEKSFNYDFSVIMPIYNVELYLTEAIESIINQTIGFENIQLIL VNDDSPDKSEIICKEYAQKYPNNIVYAKKQNGGVSSARNYGLKYAEGRYIQFLDPDDL VSEGTFENVLNFFDEHKNEIDIVAIPIFFAEGRTGEHNLNNKFSSTRILDVEKEPHHI LTHCCSTFIKKDALKNIRFDENCKIGEDAKLVNLIISQKKKYGLVKEAKYHYRVREDG SSAMQTAKANKNWFNHSLITFSKNLIDIIKNHEQKIPLFLQYMVMHDLKWKLLIKDIS ETPLDENEYSEFLTLIREVLSYIDDDVIIETKSVSHFYLYHALKIKHGENYSRYVYER ETEQDYYLYREGKIVSKLSDQTLTIEILEENEDSIHIEGFWSSLFNSKGFKFYAKIGE TKIKAKNIKRQHNDYISLGEVIKKYPGFSIDIPKGHLADNHHIEFFITKGKKRKLTKL RFFKYSGLSNDLYNTYVAKKDYIFYYNYKKLMFKKNNFKNRFIKEFRFLKSLHKSGEK SKKRKSAIKKALMARMVHHVFTIFNRKPVWLFIDRQDKADDNAEHLFKYAINKNDGVK KYFIIKKDSKDYDRIKKYGKVIPYRSFRHKILTLSSSKVISTHADIWVVNPFFNMEIY FRDLFNFEFIFLQHGITMADHSEWLNKYNKNIKLLVTSAKPEYRSIVKGNYNYKKENI LLGGFPRYDNLKKSEGEKQLLIMPTWRKDIVLPKDQAKGVRPYNPKFKDSEYFSRYNA LINDERLIEFAKKNNYKITFFPHPDIQQQIVDFEKHDYVEFADYNSSYQMLFNSSNIM ITDFSSVAFDFAYEKKPVIYYQYEKSYHFKLDYYDYKKMGFGDVLENHNSLVDKVIYY MKNNSRMEDKYRKRVDNFFAYTDKNNRNRIYNAILELDNNKVAK*" /label="ggaB CDS" gene complement(3291532..3294234) /gene="ggaB" /locus_tag="BSU_35680" /old_locus_tag="BSU35680" /label="ggaB gene" S_feature complement(3294235..3294357) /Source="Nicolas_S_feature" /locus_tag="new_3669912_3670034_c" /HighExp="BMM, HiOs, MG 15, C30, SMM, GM 90, HPh, MG 150, MG 25, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD" /TUshortPSig="1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1366" promotor_-35 3294256..3294262 /Source="Nicolas_upshift_promotors" /id="U2792" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=207 /SigmaFactorBS="ttttttcgttcataaaagattactcctaacataaTGTTTATa tgaataagaattcGGGTAAATAAAATTAAGAAacaagagagtactaatttttgcaaaa c" /listShort="S1367, S1370, yvzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3294277..3294295 /Source="Nicolas_upshift_promotors" /id="U2792" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=207 /SigmaFactorBS="ttttttcgttcataaaagattactcctaacataaTGTTTATa tgaataagaattcGGGTAAATAAAATTAAGAAacaagagagtactaatttttgcaaaa c" /listShort="S1367, S1370, yvzE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3294282..3297114 /Source="Nicolas_S_feature" /locus_tag="new_3669959_3672791" /HighExp="Sw, LoTm, M9-stat, Salt, B60, T0.30H, Gly, T1.0H, B36, BI" /AntisenseName="ggaA" /AntisenseCor="-0.503651102561819" /AntisenseRegPval="-18" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1367" upshifts 3294282 /Source="Nicolas_upshifts" /id="U2792" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=207 /SigmaFactorBS="ttttttcgttcataaaagattactcctaacataaTGTTTATa tgaataagaattcGGGTAAATAAAATTAAGAAacaagagagtactaatttttgcaaaa c" /listShort="S1367, S1370, yvzE" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3294358..3295698) /gene="ggaA" /locus_tag="BSU_35690" /old_locus_tag="BSU35690" /function="16.5: Explore" /function="16.8: Protect" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16735734, 7704262; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="poly(glucosyl N-acetylgalactosamine 1-phosphate)glucosyltransferase (missing signal peptide)" /db_xref="EnsemblGenomes-Gn:BSU35690" /db_xref="EnsemblGenomes-Tr:CAB15586" /db_xref="GOA:P46917" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="PSEUDO:CAB15586.1" /db_xref="SubtiList:BG11367" /db_xref="UniProtKB/Swiss-Prot:P46917" /translation="MFSIIIPIYNSENYLRYSIESVLNQSIGFKENIELILIDDGSVD SSPQICESFKNLYPNNIKIMKIENSGPSAARNCGLSNVSERSKFIGFLDSDDAFSQNA LQSVYDFFCDSEHVNIAVLPVYYTGEKEGGHKLNNRFEKGTRVINILNDYKAIHFYIG GTFYRRHTLTSTVLFDESIKFWEDAIFFNQLLLKEKRYGAVAEGKYFYRKRKEQDSLV DRSWFNKKRYTYLLNECYMTLLMDSFNKYDIVLPYLQFLIVYHIKLFLYPNYRDVYKS VLDQQEQRVFVDDFIKVLKFIDPQFIKEQDMPMYYKEFMFHLLKENTEALENIKKERV LHSSCTVTSAKIKGLRLELTGHFINQYYEMKENDRIYIKYFKRLKKCKRKELKKTIEV WGYKLRDFRYAGFVVEIPIWAFAFDFVLKTPNDSLELNHVNIFKSLLTRVFKKR*" /label="ggaA CDS" gene complement(3294358..3295698) /gene="ggaA" /locus_tag="BSU_35690" /old_locus_tag="BSU35690" /pseudo /label="ggaA gene" CDS complement(3295739..3295945) /gene="yvzI" /locus_tag="BSU_35698" /old_locus_tag="BSU35698" /EC_number="2.7.8.12" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId: 7704262; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative CDP-glycerol:poly(glycerophosphate) glycerophosphotransferase (fragment)" /db_xref="PSEUDO:CAX52701.1" /translation="MYDLPAYRDCIRGFYFNFQQKTPGNLLQTSEELIDTVKELLHNP YIDHNYEDFYNKFCNLEEARLLKE*" /label="yvzI CDS" gene complement(3295739..3295945) /gene="yvzI" /locus_tag="BSU_35698" /old_locus_tag="BSU35698" /pseudo /label="yvzI gene" S_feature complement(3295946..3296819) /Source="Nicolas_S_feature" /locus_tag="new_3671623_3672496_c" /HighExp="HiOs, Heat, BMM, MG 15, GM 90, MG 25, MG 150, C30, GM 25, MG 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99943499999999996" /TUshortSig="SigA, SigD" /TUshortPSig="1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1368" promotor_-10 complement(3296813..3296832) /Source="Nicolas_upshift_promotors" /id="U2793" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=3053 /SigmaFactorBS="gtgctgatgatttacatttttaaagagcCTTAACTtttatag gaacaTATGCTATTATTGTTTATTAttaatggaacgtaaaaaatatgtcgaaatgata a" /listShort="S1368, yvzI, ggaA, S1366, ggaB, S1365, yvzH, S1364" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3296819) /Source="Nicolas_upshifts" /id="U2793" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=3053 /SigmaFactorBS="gtgctgatgatttacatttttaaagagcCTTAACTtttatag gaacaTATGCTATTATTGTTTATTAttaatggaacgtaaaaaatatgtcgaaatgata a" /listShort="S1368, yvzI, ggaA, S1366, ggaB, S1365, yvzH, S1364" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3296821..3297060) /Source="Nicolas_S_feature" /locus_tag="new_3672498_3672737_c" /HighExp="Cold, LBGstat, C30, GM 25, GM 15, GM 45, GM 60, GM 10, GM-0.2, GM 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1369" promotor_-35 complement(3296845..3296851) /Source="Nicolas_upshift_promotors" /id="U2793" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=3053 /SigmaFactorBS="gtgctgatgatttacatttttaaagagcCTTAACTtttatag gaacaTATGCTATTATTGTTTATTAttaatggaacgtaaaaaatatgtcgaaatgata a" /listShort="S1368, yvzI, ggaA, S1366, ggaB, S1365, yvzH, S1364" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3297042..3297060) /Source="Nicolas_upshift_promotors" /id="U2794" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=2827 /SigmaFactorBS="ttcactaaattttaccacgaaaatttttaggaactacgtATT ACAATtccttcacgttttGACGATGAAGTAATATGAGgagggcgtacaaaataaatga c" /listShort="S1369, S1368, yvzI, ggaA, S1366, ggaB, S1365, yvzH" /listLong="S1364" /label="promotor_-10" upshifts complement(3297060) /Source="Nicolas_upshifts" /id="U2794" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=2827 /SigmaFactorBS="ttcactaaattttaccacgaaaatttttaggaactacgtATT ACAATtccttcacgttttGACGATGAAGTAATATGAGgagggcgtacaaaataaatga c" /listShort="S1369, S1368, yvzI, ggaA, S1366, ggaB, S1365, yvzH" /listLong="S1364" /label="upshifts" promotor_-35 complement(3297074..3297081) /Source="Nicolas_upshift_promotors" /id="U2794" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=2827 /SigmaFactorBS="ttcactaaattttaccacgaaaatttttaggaactacgtATT ACAATtccttcacgttttGACGATGAAGTAATATGAGgagggcgtacaaaataaatga c" /listShort="S1369, S1368, yvzI, ggaA, S1366, ggaB, S1365, yvzH" /listLong="S1364" /label="promotor_-35" promotor_-35 3297083..3297090 /Source="Nicolas_upshift_promotors" /id="U2795" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2179 /SigmaFactorBS="tcgtcaaaacgtgaaggaattgtaataCGTAGTTCctaaaaa ttttCGTGGTAAAATTTAGTGAAGtctttatcaggctaagggactttatctaaactac g" /listShort="S1370, yvzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3297102..3297121 /Source="Nicolas_upshift_promotors" /id="U2795" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2179 /SigmaFactorBS="tcgtcaaaacgtgaaggaattgtaataCGTAGTTCctaaaaa ttttCGTGGTAAAATTTAGTGAAGtctttatcaggctaagggactttatctaaactac g" /listShort="S1370, yvzE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3297116..3297246 /Source="Nicolas_S_feature" /locus_tag="new_3672793_3672923" /HighExp="Sw, T0.30H, LoTm, B60, T1.0H, Lbtran, C30, LBGtran, dia5, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1370" upshifts 3297116 /Source="Nicolas_upshifts" /id="U2795" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2179 /SigmaFactorBS="tcgtcaaaacgtgaaggaattgtaataCGTAGTTCctaaaaa ttttCGTGGTAAAATTTAGTGAAGtctttatcaggctaagggactttatctaaactac g" /listShort="S1370, yvzE" /GFF_Attribute="listLong" /label="upshifts" promotor_no_box 3297188..3297288 /Source="Nicolas_upshift_promotors" /id="U2796" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.711288711288711" /psig="0.104895104895105" /xcortree=14 /SigmaFactorBS="agggttgatatgatataaacgaaaatcaattagataaaggaa aaactgaacacttctgaaaaaagtgataagtttctttcactatatcctccaaaaagaa c" /listShort="yvzE" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 3297248 /Source="Nicolas_upshifts" /id="U2796" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.711288711288711" /psig="0.104895104895105" /xcortree=14 /SigmaFactorBS="agggttgatatgatataaacgaaaatcaattagataaaggaa aaactgaacacttctgaaaaaagtgataagtttctttcactatatcctccaaaaagaa c" /listShort="yvzE" /GFF_Attribute="listLong" /label="upshifts" CDS 3297252..3297848 /gene="yvzE" /locus_tag="BSU_35699" /old_locus_tag="BSU35699" /EC_number="2.7.7.9" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; Product type e : enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative UTP-glucose-1-phosphate uridylyltransferase (UDP-glucose pyrophosphorylase) (UDPGP) (fragment)" /db_xref="PSEUDO:CAX52702.1" /translation="MISFFHYILQKEPKGLGHAVWFAPNFIGDEPFAFLLGDDIVQAD TPGLRQLTDEYERTLSSIIGVQQVPEDETHCYGIIAPLTSEGRRYQVKNFIEKPPKDT APSNLAILGRYVFTPEIFMYLEEQQVGAGGEIQLTDAIQKLNEIQRVFAYDFEGKRYD VGEKLGFITTTLEFAMQDKELRDQLVPFMEGLLNKEEI*" /label="yvzE CDS" gene 3297252..3297848 /gene="yvzE" /locus_tag="BSU_35699" /old_locus_tag="BSU35699" /pseudo /label="yvzE gene" downshifts 3297446 /Source="Nicolas_upshifts" /id="D1844" /incds=1 /nref=94 /ntot=183 /MaxReadThrough="4.62614" /MaxDrop="5.15039" /score="34.2325445" /energy="-14.3" /TU="U2792,U2795" /idTUdmin="U2796" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3297887..3299470) /gene="tagH" /locus_tag="BSU_35700" /old_locus_tag="BSU35700" /EC_number="3.6.3.40" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7565096, 12682299, 17012386, 18156271; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ATP-binding teichoic acid precursor transporter component" /protein_id="NP_391451.1" /db_xref="EnsemblGenomes-Gn:BSU35700" /db_xref="EnsemblGenomes-Tr:CAB15587" /db_xref="GOA:P42954" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR015860" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030284" /db_xref="SubtiList:BG11191" /db_xref="UniProtKB/Swiss-Prot:P42954" /translation="MKLKVSFRNVSKQYHLYKKQSDKIKGLFFPAKDNGFFAVRNVSF DVYEGETIGFVGINGSGKSTMSNLLAKIIPPTSGEIEMNGQPSLIAIAAGLNNQLTGR DNVRLKCLMMGLTNKEIDDMYDSIVEFAEIGDFINQPVKNYSSGMKSRLGFAISVHID PDILIIDEALSVGDQTFYQKCVDRINEFKKQGKTIFFVSHSIGQIEKMCDRVAWMHYG ELRMFDETKTVVKEYKAFIDWFNKLSKKEKETYKKEQTEERKKEDPEAFARFRKKKKK PKSLANAIQIAILSILTVFMAGTMFFNAPLRTIASFGAIPQNEVKNHHGDAKGKSEER LTAINKQGFIANEKAAAYKDQGLKQKADVTLPFGTKVTVAAKGKQAAKIKFDGHSYYV KQSAVATNMKHAELHATAFTSYVSQNAASSYEYFLKFLGDSSTSIQSKLNGYTEGNKA DGRKTLNFDYEKISYVLENDKATELIFHNISPINPASLSLSDSDVLYDSSKKRFLVNT DDQVFAVDNEEHTLTLMLK*" /label="tagH CDS" gene complement(3297887..3299470) /gene="tagH" /locus_tag="BSU_35700" /old_locus_tag="BSU35700" /label="tagH gene" downshifts 3297930 /Source="Nicolas_upshifts" /id="D1845" /incds=0 /nref=2 /ntot=19 /MaxReadThrough="1.20059" /MaxDrop="5.25978" /score="34.2325445" /energy="-14.3" /TU="NA" /idTUdmin="U2792" /TUdmin=440 /isTUend="FALSE" /label="downshifts" CDS complement(3299490..3300317) /gene="tagG" /locus_tag="BSU_35710" /old_locus_tag="BSU35710" /function="16.8: Protect" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7565096, 12682299, 15849754, 16850406, 17012386, 18156271, 27213893; Product type t: transporter" /codon_start=1 /transl_table=11 /product="teichoic acid precursors permease" /protein_id="NP_391452.1" /db_xref="EnsemblGenomes-Gn:BSU35710" /db_xref="EnsemblGenomes-Tr:CAB15588" /db_xref="GOA:P42953" /db_xref="InterPro:IPR000412" /db_xref="InterPro:IPR013525" /db_xref="SubtiList:BG11205" /db_xref="UniProtKB/Swiss-Prot:P42953" /translation="MNDLLRILREQITSFPLILRLAAYETKSKYQMNYLGVLWQFLNP LIQMLAYWFVFGMGIRKGGPVTTGAGEVPFIIWMLAGLIPWFFISPTILDGSNSVFKR INMVAKMNFPISSLPSVAIASNLFSYMIMMVIYIIVLLVNGVFPSVHWLQYIYYFICM IAFMFSFSLFNSTISVLIRDYQFLLQAVTRLLFFLLPIFWDVNAKLGQSHPELVPVLK LNPLFYIIEGFRNSFLDGAWFFHDMKYTLYFWLFTFLLLLVGSILHMKFRDKFVDFL* " /label="tagG CDS" gene complement(3299490..3300317) /gene="tagG" /locus_tag="BSU_35710" /old_locus_tag="BSU35710" /label="tagG gene" S_feature complement(3300318..3300382) /Source="Nicolas_S_feature" /locus_tag="new_3675995_3676059_c" /HighExp="H2O2, LBGstat, dia15, Oxctl, LBGexp, G150, Paraq, G180, G135, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1371" promotor_-10 complement(3300378..3300397) /Source="Nicolas_upshift_promotors" /id="U2797" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.93006993006993" /psig="0.999000999001" /xcortree=1823 /SigmaFactorBS="ggcagctttttagatacttgttgagaAGTGaaaaaaaatgca ggaTCTGTTACAATAATCAGCGGtgctttcaaattttaaacagaaagattcccaaaaa c" /listShort="S1371, tagG, tagH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3300382) /Source="Nicolas_upshifts" /id="U2797" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.93006993006993" /psig="0.999000999001" /xcortree=1823 /SigmaFactorBS="ggcagctttttagatacttgttgagaAGTGaaaaaaaatgca ggaTCTGTTACAATAATCAGCGGtgctttcaaattttaaacagaaagattcccaaaaa c" /listShort="S1371, tagG, tagH" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3300384..3300481) /Source="Nicolas_S_feature" /locus_tag="new_3676061_3676158_c" /HighExp="G180, G135, Cold, G150, LPh, S0, Oxctl, Paraq, HPh, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1372" promotor_-35 complement(3300413..3300416) /Source="Nicolas_upshift_promotors" /id="U2797" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.93006993006993" /psig="0.999000999001" /xcortree=1823 /SigmaFactorBS="ggcagctttttagatacttgttgagaAGTGaaaaaaaatgca ggaTCTGTTACAATAATCAGCGGtgctttcaaattttaaacagaaagattcccaaaaa c" /listShort="S1371, tagG, tagH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3300482..3302722) /gene="tagF" /locus_tag="BSU_35720" /old_locus_tag="BSU35720" /EC_number="2.7.8.12" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 16141206, 16689786, 17012386, 18723614, 19520862, 20400947" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16141206, 16689786, 17012386, 18723614, 19520862, 20400947; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="CDP-glycerol:polyglycerol phosphate glycero-phosphotransferase (poly(glycerol phosphate) polymerase)" /protein_id="NP_391453.1" /db_xref="EnsemblGenomes-Gn:BSU35720" /db_xref="EnsemblGenomes-Tr:CAB15589" /db_xref="GOA:P13485" /db_xref="InterPro:IPR007554" /db_xref="SubtiList:BG10725" /db_xref="UniProtKB/Swiss-Prot:P13485" /translation="MSLVVDTNKRKQKGKSFYTEEQKKVMIENTVIKCILKSLKNNLG SLELLISIDSEHQFLEDYQLFLKLKERRSGTESEFPLQNTGSLEYKTEINAHVLPMPV EMGQTYDFYVEFRKKYEDAEQEPLLKRLSAEVNSIERAFHVDQTTELLILPYTTDKGN FSIKVKREAKIIRFDQIEISSEEISITGYAGYLSSENQYRIKNLNLILKKGGETPIEE KFPIKLERKTHGLENMRADGFVPELYDFEVKVPLKEIPFSNEKRYVYRLFMEYICNDD EGTDIQFNSTALVLGDRKNKLKGLVSIIKTNNAPVRYEVFKKKKKQTLGIRVNDYSLK TRMKYFIKGKKKRLVSKIKKITKMRNKLITKTYKSLFMMASRMPVKRKTVIFESFNGK QYSCNPRAIYEYMRENHPEYKMYWSVNKQYSAPFDEKGIPYINRLSLKWLFAMARAEY WVVNSRLPLWIPKPSHTTYLQTWHGTPLKRLAMDMEEVHMPGTNTKKYKRNFIKEASN WDYLISPNGYSTEIFTRAFQFNKTMIESGYPRNDFLHNDNNEETISLIKSRLNIPRDK KVILYAPTWRDDQFYAKGRYKFDLDLDLHQLRQELGNEYIVILRMHYLVAENFDLGPF EGFAYDFSAYEDIRELYMVSDLLITDYSSVFFDFANLKRPMLFFVPDIETYRDKLRGF YFDFEKEAPGPLVKTTEETIEAIKQISSPDYKLPVSFGPFYDKFCYLESGRSSEKVVN TVFKAE*" /label="tagF CDS" gene complement(3300482..3302722) /gene="tagF" /locus_tag="BSU_35720" /old_locus_tag="BSU35720" /label="tagF gene" CDS complement(3302722..3304743) /gene="tagE" /locus_tag="BSU_35730" /old_locus_tag="BSU35730" /EC_number="2.4.1.52" /function="16.8: Protect" /function="16.5: Explore" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2507871, 9457886, 12682299, 16141206, 16689786, 17012386, 21558268" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2507871, 9457886, 12682299, 16141206, 16689786, 17012386, 21558268; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-glucose:polyglycerol phosphate alpha-glucosyltransferase" /protein_id="NP_391454.1" /db_xref="EnsemblGenomes-Gn:BSU35730" /db_xref="EnsemblGenomes-Tr:CAB15590" /db_xref="GOA:P13484" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR015397" /db_xref="SubtiList:BG10724" /db_xref="UniProtKB/Swiss-Prot:P13484" /translation="MSLHAVSESNIKQIPDMDYYFISGGLPSNYGGLTKSLLLRSKLF GEECNQNTFFLTFRFDLELSSKIDELYSNGKIDKKFTSVINLFDDFLSVRTNGKRSYE ERIGLDQIKKQVGMGKFAKTLLRLFGKKNNEMSVVYYGDGETIRYVDYWNDKNQLIKR EEYTKNGNLVLVTHYDVQLNKMYLQEYINDQNQVYLDKLYVWNNEEKDVQLSHIIWYS LEGEIKVKDESELRQYWIEYLQKQNDKPKLFLVDSRPQDKHVFKVKKSPSSYYGAIIH NKHYGSNKYQIKGRYKEVFSQMYNLDAVFFITEEQLEDFKLISGEQETFFFTPHTIDK PLDPAVLNVPSEKYKAVIISRLASMKNLIHAVKAFSLVVKEIPEAKLDIFGSGEDFEK IKKEIEDTKLQNNVFLKGYTDNPDSEFQKAWLTISTSHFEGFGLSNMEALSNGCPVVT YDYDYGARSLVTDGANGYVIEQYNIEKLGQAIISLMKDESTHQKFSEQAFKMAEKYSR PNYIENWAFALNQMIEVRIEREKFSKKVGKKDPSISSYTEDFDKTKIEIDIENFDHND IKKIRLVGLDRKNKAEIISTNLQNDQLFVIDLEKDVNIEKIAANKTQVIDFYIVFNAN GHIKTMRRLSSEETKLSGNSIDTNNGYRVEPYTTVKGNFSWRVTEIKES*" /label="tagE CDS" gene complement(3302722..3304743) /gene="tagE" /locus_tag="BSU_35730" /old_locus_tag="BSU35730" /label="tagE gene" promotor_-35 3303485..3303494 /Source="Nicolas_upshift_promotors" /id="U2798" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1685 /SigmaFactorBS="gaggttgaaatggttagccaagcttttTGAAACTCTGagtca gggttatCCGTATAGCCTTTCAAaaagacattgttctgcagtttggtatcttcaattt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3303507..3303522 /Source="Nicolas_upshift_promotors" /id="U2798" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1685 /SigmaFactorBS="gaggttgaaatggttagccaagcttttTGAAACTCTGagtca gggttatCCGTATAGCCTTTCAAaaagacattgttctgcagtttggtatcttcaattt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3303518 /Source="Nicolas_upshifts" /id="U2798" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1685 /SigmaFactorBS="gaggttgaaatggttagccaagcttttTGAAACTCTGagtca gggttatCCGTATAGCCTTTCAAaaagacattgttctgcagtttggtatcttcaattt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3304744..3304903) /Source="Nicolas_S_feature" /locus_tag="new_3680421_3680580_c" /HighExp="G180, G135, Cold, G150, Oxctl, LBGexp, Paraq, Lbexp, LPhT, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1373" CDS complement(3304904..3305293) /gene="tagD" /locus_tag="BSU_35740" /old_locus_tag="BSU35740" /EC_number="2.7.7.39" /function="16.8: Protect" /function="16.5: Explore" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11673441, 12637027, 12637499, 12682299, 16141206, 16689786, 17012386, 21558268" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11673441, 12637027, 12637499, 12682299, 16141206, 16689786, 17012386, 21558268; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycerol-3-phosphate cytidylyltransferase" /protein_id="NP_391455.1" /db_xref="EnsemblGenomes-Gn:BSU35740" /db_xref="EnsemblGenomes-Tr:CAB15591" /db_xref="GOA:P27623" /db_xref="InterPro:IPR004821" /db_xref="InterPro:IPR006409" /db_xref="InterPro:IPR014729" /db_xref="PDB:1COZ" /db_xref="PDB:1N1D" /db_xref="SubtiList:BG10449" /db_xref="UniProtKB/Swiss-Prot:P27623" /translation="MKKVITYGTFDLLHWGHIKLLERAKQLGDYLVVAISTDEFNLQK QKKAYHSYEHRKLILETIRYVDEVIPEKNWEQKKQDIIDHNIDVFVMGDDWEGKFDFL KDQCEVVYLPRTEGISTTKIKEEIAGL*" /label="tagD CDS" gene complement(3304904..3305293) /gene="tagD" /locus_tag="BSU_35740" /old_locus_tag="BSU35740" /label="tagD gene" S_feature complement(3305294..3305428) /Source="Nicolas_S_feature" /locus_tag="new_3680971_3681105_c" /HighExp="BC, Cold, T3.0H, HiOs, MG-0.2, T1.30H, T3.30H, LPhT, MG 15, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1374" promotor_-10 complement(3305412..3305431) /Source="Nicolas_upshift_promotors" /id="U2799" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2289 /SigmaFactorBS="taattacatattttggaatgtttttctcctcatgagtacTTA ACCTTttttaggcggTATGCTATAATTAATGATCAgtgaagacatacgagaaatatgt c" /listShort="S1374, tagD, S1373, tagE, tagF, S1372, S1371, tagG, tagH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3305428) /Source="Nicolas_upshifts" /id="U2799" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2289 /SigmaFactorBS="taattacatattttggaatgtttttctcctcatgagtacTTA ACCTTttttaggcggTATGCTATAATTAATGATCAgtgaagacatacgagaaatatgt c" /listShort="S1374, tagD, S1373, tagE, tagF, S1372, S1371, tagG, tagH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3305442..3305449) /Source="Nicolas_upshift_promotors" /id="U2799" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2289 /SigmaFactorBS="taattacatattttggaatgtttttctcctcatgagtacTTA ACCTTttttaggcggTATGCTATAATTAATGATCAgtgaagacatacgagaaatatgt c" /listShort="S1374, tagD, S1373, tagE, tagF, S1372, S1371, tagG, tagH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3305583..3305589 /Source="Nicolas_upshift_promotors" /id="U2800" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp=1 /psig=1 /xcortree=2129 /SigmaFactorBS="gtaaaattggaaacatatttaaatttaatgtaaagataatgt tAATCCTTtgttgaagattTATGTTAAAATATAAGGTAGcttgattttgcttttagaa a" /listShort="S1375, tagA, tagB, tagC" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3305600..3305692 /Source="Nicolas_S_feature" /locus_tag="new_3681277_3681369" /HighExp="B60, LoTm, Cold, T3.30H, T3.0H, Salt, T5.0H, T4.0H, Lbexp, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1375" upshifts 3305600 /Source="Nicolas_upshifts" /id="U2800" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp=1 /psig=1 /xcortree=2129 /SigmaFactorBS="gtaaaattggaaacatatttaaatttaatgtaaagataatgt tAATCCTTtgttgaagattTATGTTAAAATATAAGGTAGcttgattttgcttttagaa a" /listShort="S1375, tagA, tagB, tagC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3305601..3305620 /Source="Nicolas_upshift_promotors" /id="U2800" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp=1 /psig=1 /xcortree=2129 /SigmaFactorBS="gtaaaattggaaacatatttaaatttaatgtaaagataatgt tAATCCTTtgttgaagattTATGTTAAAATATAAGGTAGcttgattttgcttttagaa a" /listShort="S1375, tagA, tagB, tagC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3305693..3306463 /gene="tagA" /locus_tag="BSU_35750" /old_locus_tag="BSU35750" /EC_number="2.4.1.187" /function="16.5: Explore" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12682299, 16141206, 16689786, 16953575, 17012386, 18156271, 19376878" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16141206, 16689786, 16953575, 17012386, 18156271, 19376878; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylmannosamine (ManNAc) C4 hydroxyl of a membrane-anchored N-acetylglucosaminyl diphospholipid (GlcNAc-pp-undecaprenyl, lipid I) glycosyltransferase" /protein_id="NP_391456.1" /db_xref="EnsemblGenomes-Gn:BSU35750" /db_xref="EnsemblGenomes-Tr:CAB15592" /db_xref="GOA:P27620" /db_xref="InterPro:IPR004629" /db_xref="InterPro:IPR034714" /db_xref="SubtiList:BG10450" /db_xref="UniProtKB/Swiss-Prot:P27620" /translation="MQTETIHNIPYVNSNLTSFIDYLEKHYIDQKIGAVISTVNPEIA FAAIKDRDYFDVLSSSNFILPDGIGVVMMSRLTNNRLQSRIAGYDVFKELLGVANKKK KRIFLYGAKKDVIKGVVSKISSEYPNIKIAGYSDGYVQDRTLVAKQIARANPDMVFVA LGYPHQEKFIHNYRHLFPKAVSIGLGGSFDVFSGNVKRAPSWMIRLNLEWFYRLILNP WRWKRMLSIPKYALTVLKEEKNKKTFYPKPEKDHTKQI*" /label="tagA CDS" gene 3305693..3306463 /gene="tagA" /locus_tag="BSU_35750" /old_locus_tag="BSU35750" /label="tagA gene" S_feature complement(3305820..3306168) /Source="Nicolas_S_feature" /locus_tag="new_3681497_3681845_c" /HighExp="S8, S6, S7, S5, S4, G135, S3, C30, G180, ferm" /AntisenseName="tagA" /AntisenseCor="-0.35014495927301897" /AntisenseRegPval="-8.5" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1376" promotor_-10 complement(3306172..3306183) /Source="Nicolas_upshift_promotors" /id="U2801" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=949 /SigmaFactorBS="atacggctttagggaacaagtgtctgtagttaTGAATGAatt tctcttgatgaGGATACCCTAAAgctacgaataccatgtcaggatttgctcttgcaat t" /listShort="S1376" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3306176) /Source="Nicolas_upshifts" /id="U2801" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=949 /SigmaFactorBS="atacggctttagggaacaagtgtctgtagttaTGAATGAatt tctcttgatgaGGATACCCTAAAgctacgaataccatgtcaggatttgctcttgcaat t" /listShort="S1376" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3306198..3306204) /Source="Nicolas_upshift_promotors" /id="U2801" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=949 /SigmaFactorBS="atacggctttagggaacaagtgtctgtagttaTGAATGAatt tctcttgatgaGGATACCCTAAAgctacgaataccatgtcaggatttgctcttgcaat t" /listShort="S1376" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3306488 /Source="Nicolas_upshifts" /id="D1846" /incds=0 /nref=2 /ntot=103 /MaxReadThrough="6.64821" /MaxDrop="3.225" /score="-6.01444425" /energy="-10.9" /TU="U2800" /idTUdmin="U2800" /TUdmin="-2310" /isTUend="FALSE" /label="downshifts" CDS 3306496..3307641 /gene="tagB" /locus_tag="BSU_35760" /old_locus_tag="BSU35760" /EC_number="2.7.8.44" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12682299, 16141206, 16150696, 16689786, 17012386, 17660278, 18156271, 18761696" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16141206, 16150696, 16689786, 17012386, 17660278, 18156271, 18761696; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="teichoic acid primase, CDP-glycerol:N-acetyl-beta-d-mannosaminyl-1, 4-N-acetyl-d-glucosaminyldiphosphoundecaprenyl glycerophosphotransferase" /protein_id="NP_391457.1" /db_xref="EnsemblGenomes-Gn:BSU35760" /db_xref="EnsemblGenomes-Tr:CAB15593" /db_xref="GOA:P27621" /db_xref="InterPro:IPR007554" /db_xref="SubtiList:BG10451" /db_xref="UniProtKB/Swiss-Prot:P27621" /translation="MKIRSLLANCYLYFLSAIAFFLQWVKPESKVTLLISFEANAKAI LEEYEQGQYSYKLNILYTQQASAIAESFPNVDAYLLQEKNPIHLIKAVYLMFNSKVII TDNYFLLTSVLNKRKQTKCIQVWHANGSLKKFGLEDITNMQRTKTDIKRFQKVYSSYD YLTVGSEEMANIFKKSFGIKDNQLLKIGVPLTDPYYRENKKKISDTLNIQRKKIILYA PTFRDYNMQSIQLPFTEEQLIHQLKEEYVLFVKLHPAIQNNIDIKYSSDYIKDVSNYA LFDLLMAADILITDYSSVPFEFSILNKPILFYTYDLKLYQQKRGLVDNYLSIIPGRAC YDSESLINEIQTPFNYSKIKVFSDRWNKYSDGNSSQNLLNFIENLIS*" /label="tagB CDS" gene 3306496..3307641 /gene="tagB" /locus_tag="BSU_35760" /old_locus_tag="BSU35760" /label="tagB gene" downshifts 3307629 /Source="Nicolas_upshifts" /id="D1847" /incds=0 /nref=101 /ntot=235 /MaxReadThrough="3.54908" /MaxDrop="5.95551" /score="-3.22062454" /energy="-10" /TU="U2800" /idTUdmin="U2800" /TUdmin="-1169" /isTUend="FALSE" /label="downshifts" promotor_-35 3307683..3307690 /Source="Nicolas_upshift_promotors" /id="U2802" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.894105894105894" /psig=1 /xcortree=1505 /SigmaFactorBS="ttcaaaacagaacaagtgttcttttttcTATTGAATaccgaa cgtatgttTGCTTTAATGTAATTAGTTGcttatggcagcaaataataatagaggtggt a" /listShort="tagC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3307705..3307724 /Source="Nicolas_upshift_promotors" /id="U2802" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.894105894105894" /psig=1 /xcortree=1505 /SigmaFactorBS="ttcaaaacagaacaagtgttcttttttcTATTGAATaccgaa cgtatgttTGCTTTAATGTAATTAGTTGcttatggcagcaaataataatagaggtggt a" /listShort="tagC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3307715 /Source="Nicolas_upshifts" /id="U2802" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.894105894105894" /psig=1 /xcortree=1505 /SigmaFactorBS="ttcaaaacagaacaagtgttcttttttcTATTGAATaccgaa cgtatgttTGCTTTAATGTAATTAGTTGcttatggcagcaaataataatagaggtggt a" /listShort="tagC" /GFF_Attribute="listLong" /label="upshifts" CDS 3307761..3309089 /gene="tagC" /locus_tag="BSU_35770" /old_locus_tag="BSU35770" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7952180, 16269821; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative polyglycerol phosphate assembly and export protein (teichoic acid biosynthesis)" /protein_id="NP_391458.1" /db_xref="EnsemblGenomes-Gn:BSU35770" /db_xref="EnsemblGenomes-Tr:CAB15594" /db_xref="GOA:P27622" /db_xref="InterPro:IPR011042" /db_xref="SubtiList:BG10453" /db_xref="UniProtKB/Swiss-Prot:P27622" /translation="MRKKELFDFTNITPKLFTELRVADKTVLQSFNFDEKNHQIYTTQ VASGLGKDNTQSYRITRLSLEGLQLDSMLLKHGGHGTNIGIENRNGTIYIWSLYDKPN ETDKSELVCFPYKAGATLDENSKELQRFSNMPFDHRVTPALDMKNRQLAIRQYDTKNN NNKQWVTIFNLDDAIANKNNPLYTINIPDELHYLQGFFLDDGYLYWYTGDTNSKSYPN LITVFDSDNKIVLQKEITVGKDLSTRYENNFREPEGICMYTNPETGAKSLMVGITSGK EGNRISRIYAYHSYENFMNHVPMLRSPLLKTVGHQDTPPERFQPFIQTFILEYNAQNK KWMVPTSGYLPSYTSNLVRNITINADGNLQVTLNERYISLLHQSIEGDFRLKQKDIRM GSWYFAGGEKSNVLEIGFMKGSTKIRPDDAAISNASRMSIFMIVADKIEV*" /label="tagC CDS" gene 3307761..3309089 /gene="tagC" /locus_tag="BSU_35770" /old_locus_tag="BSU35770" /label="tagC gene" downshifts 3309084 /Source="Nicolas_upshifts" /id="D1848" /incds=0 /nref=1 /ntot=29 /MaxReadThrough="2.77356" /MaxDrop="4.002" /score="-7.52215775" /energy="-19.3" /TU="NA" /idTUdmin="U2802" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(3309145) /Source="Nicolas_upshifts" /id="D1849" /incds=0 /nref=141 /ntot=248 /MaxReadThrough="0.94732" /MaxDrop="5.40128" /score="-0.11635468" /energy="-19.3" /TU="NA" /idTUdmin="U2803" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(3309149..3311791) /gene="lytD" /locus_tag="BSU_35780" /old_locus_tag="BSU35780" /EC_number="3.2.1.96" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9537764, 10206711, 17298895, 19542270, 22469514" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9537764, 10206711, 17298895, 19542270, 22469514; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported N-acetylglucosaminidase (major autolysin) (CWBP90)" /protein_id="NP_391459.1" /db_xref="EnsemblGenomes-Gn:BSU35780" /db_xref="EnsemblGenomes-Tr:CAB15595" /db_xref="GOA:P39848" /db_xref="InterPro:IPR002901" /db_xref="InterPro:IPR003646" /db_xref="InterPro:IPR007730" /db_xref="InterPro:IPR036680" /db_xref="SubtiList:BG10455" /db_xref="UniProtKB/Swiss-Prot:P39848" /translation="MKKRLIAPMLLSAASLAFFAMSGSAQAAAYTDYSLYKVEPSNTF STESQASQAVAKLEKDTGWDASYQASGTTTTYQISASGIHSESEAKAILSGLAKQTSI TGTSSPVGSKQPYVTISSGAISGEKQANTILAKLKQETGVAGAVKAYGAAQPYMNVMT SDIADETKVKALIQSLAKQTGIKSSYQPITHTVSVTTIQSGTIVGDSRAAQIKNAFQK ESGLQASLKETVKGQAYYTFTTAAISGEANAKTLLQQLKQSTGITGSYKSINQKTTVE SYNVQSAYFKGLSTVKDAISQIKKNTGVSGSYQQVGKSTSYTVNMKGITKQQLQKIDT FFKKKKWHYTSSSVKKTTTSAAYQITTAKILGEQQANKAAAFFAQKKVKAAKTAAGST AENQYQLISEETSDQAKVTKGLNILKKNQLSASAKSVKKQIADTFKITTESLLDQTKV NQALTFFKSNHISVASQKTGQTAASSYQITTEAIISQEEIDRVLTFFKQNHIAVTTSK TGQTAYTQYKIVTTQLSSKTALNNGLTYLKSKSVTPSYTTKSNTLYKISVNEQFTGND TAAAASTKLKQLYGWTSSIVKIKNGPQIMKTNYNLSLRDMVQKQMTVSPQTDGAAYVS LTYINTATSTVTADVLNIRSTPEVSPTNVIGQFKKGDKVKVIGQINGWAKINLGWRNA SSDEVVQYVDPNNFSRDSKYYFQFLKLSQTAGLSVTEVNQKVLAGKGILTGRAKAFID AANQYSINELYLISHALLETGNGTSALANGLTYNGKTVYNMYGIGAYDSNPNYYGAKY AYEQGWFTPEAAIIGGAKFIGSSYIHNTAYNQDTLYKMRWSATATHQYATDIGWAYKQ VNRMYSLYSLLDGYTLYFDVPEYR*" /label="lytD CDS" gene complement(3309149..3311791) /gene="lytD" /locus_tag="BSU_35780" /old_locus_tag="BSU35780" /label="lytD gene" promotor_-10 complement(3310394..3310413) /Source="Nicolas_upshift_promotors" /id="U2803" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1231 /SigmaFactorBS="gatcaaacgaaagtcaatcagGCACTCACGTttttcaaatcg aATCATATATCAGTAGCAAGCcagaaaaccggtcagacagctgcgagcagctatcaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3310396) /Source="Nicolas_upshifts" /id="U2803" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1231 /SigmaFactorBS="gatcaaacgaaagtcaatcagGCACTCACGTttttcaaatcg aATCATATATCAGTAGCAAGCcagaaaaccggtcagacagctgcgagcagctatcaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3310426..3310435) /Source="Nicolas_upshift_promotors" /id="U2803" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1231 /SigmaFactorBS="gatcaaacgaaagtcaatcagGCACTCACGTttttcaaatcg aATCATATATCAGTAGCAAGCcagaaaaccggtcagacagctgcgagcagctatcaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3311826..3311844) /Source="Nicolas_upshift_promotors" /id="U2804" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2808 /SigmaFactorBS="tttattagaaaatggaagtgattcacCTATAAATgaagcatg cgcgtGCCGATAAATAAACTAGTTttatatactcatagaataagaaagaggagaagga a" /listShort="lytD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3311831) /Source="Nicolas_upshifts" /id="U2804" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2808 /SigmaFactorBS="tttattagaaaatggaagtgattcacCTATAAATgaagcatg cgcgtGCCGATAAATAAACTAGTTttatatactcatagaataagaaagaggagaagga a" /listShort="lytD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3311858..3311865) /Source="Nicolas_upshift_promotors" /id="U2804" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2808 /SigmaFactorBS="tttattagaaaatggaagtgattcacCTATAAATgaagcatg cgcgtGCCGATAAATAAACTAGTTttatatactcatagaataagaaagaggagaagga a" /listShort="lytD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3311920..3312870) /gene="pmiA" /locus_tag="BSU_35790" /old_locus_tag="BSU35790" /EC_number="5.3.1.8" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7581999, 10704478, 19447949, 27435445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7581999, 10704478, 19447949, 27435445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="mannose-6-phosphate isomerase (active on aldose substrates with hydroxyl groups oriented in the same direction at the C-2 and C-3 positions as in mannose)" /protein_id="NP_391460.1" /db_xref="EnsemblGenomes-Gn:BSU35790" /db_xref="EnsemblGenomes-Tr:CAB15596" /db_xref="GOA:P39841" /db_xref="InterPro:IPR001250" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014628" /db_xref="InterPro:IPR014710" /db_xref="PDB:1QWR" /db_xref="SubtiList:BG10454" /db_xref="UniProtKB/Swiss-Prot:P39841" /translation="MTQSPIFLTPVFKEKIWGGTALRDRFGYSIPSESTGECWAISAH PKGPSTVANGPYKGKTLIELWEEHREVFGGVEGDRFPLLTKLLDVKEDTSIKVHPDDY YAGENEEGELGKTECWYIIDCKENAEIIYGHTARSKTELVTMINSGDWEGLLRRIKIK PGDFYYVPSGTLHALCKGALVLETQQNSDATYRVYDYDRLDSNGSPRELHFAKAVNAA TVPHVDGYIDESTESRKGITIKTFVQGEYFSVYKWDINGEAEMAQDESFLICSVIEGS GLLKYEDKTCPLKKGDHFILPAQMPDFTIKGTCTLIVSHI*" /label="pmiA CDS" gene complement(3311920..3312870) /gene="pmiA" /locus_tag="BSU_35790" /old_locus_tag="BSU35790" /label="pmiA gene" downshifts complement(3311932) /Source="Nicolas_upshifts" /id="D1850" /incds=0 /nref=29 /ntot=177 /MaxReadThrough="4.74566" /MaxDrop="3.72936" /score="9.64549533" /energy="-7.7" /TU="U2805" /idTUdmin="U2806" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3312895..3312913) /Source="Nicolas_upshift_promotors" /id="U2805" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=167 /SigmaFactorBS="cataggaaaaaggcagcttatacgggCGTTTGTaagaggggc gcaccGGGAAAATGATGATCAGTTatttacaggggaggggtacggatcatgacgcaat c" /listShort="yvyI, lytD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3312900) /Source="Nicolas_upshifts" /id="U2805" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=167 /SigmaFactorBS="cataggaaaaaggcagcttatacgggCGTTTGTaagaggggc gcaccGGGAAAATGATGATCAGTTatttacaggggaggggtacggatcatgacgcaat c" /listShort="yvyI, lytD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3312902..3313038) /Source="Nicolas_S_feature" /locus_tag="new_3688579_3688715_c" /HighExp="Lbtran, S0, M40t90, T1.0H, dia0, Mt0, Lbstat, M0t90, Lbexp, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.17043900000000001" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S1377" promotor_-35 complement(3312928..3312934) /Source="Nicolas_upshift_promotors" /id="U2805" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=167 /SigmaFactorBS="cataggaaaaaggcagcttatacgggCGTTTGTaagaggggc gcaccGGGAAAATGATGATCAGTTatttacaggggaggggtacggatcatgacgcaat c" /listShort="yvyI, lytD" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(3313012..3313031) /Source="Nicolas_upshift_promotors" /id="U2806" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.664335664335664" /psig="0.994005994005994" /xcortree=1553 /SigmaFactorBS="tattaatttgtatcaaaaaaggagaattattcttatcgagga aaaggctgaaacaaagcttcttttcgaCGTGATATAATAGATAGGAAgcgttttcttt g" /listShort="S1377, yvyI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3313040) /Source="Nicolas_upshifts" /id="U2806" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.664335664335664" /psig="0.994005994005994" /xcortree=1553 /SigmaFactorBS="tattaatttgtatcaaaaaaggagaattattcttatcgagga aaaggctgaaacaaagcttcttttcgaCGTGATATAATAGATAGGAAgcgttttcttt g" /listShort="S1377, yvyI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3313068..3313074 /Source="Nicolas_upshift_promotors" /id="U2807" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=900 /SigmaFactorBS="cacgtcgaaaagaagctttgtttcagccttttcctcgataAG AATAAttctccttttttgATACAAATTAATaaaaaccgtcaatatgtttaagaaggag a" /listShort="gerBA, gerBB, gerBC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3313088..3313099 /Source="Nicolas_upshift_promotors" /id="U2807" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=900 /SigmaFactorBS="cacgtcgaaaagaagctttgtttcagccttttcctcgataAG AATAAttctccttttttgATACAAATTAATaaaaaccgtcaatatgtttaagaaggag a" /listShort="gerBA, gerBB, gerBC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3313088 /Source="Nicolas_upshifts" /id="U2807" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=900 /SigmaFactorBS="cacgtcgaaaagaagctttgtttcagccttttcctcgataAG AATAAttctccttttttgATACAAATTAATaaaaaccgtcaatatgtttaagaaggag a" /listShort="gerBA, gerBB, gerBC" /GFF_Attribute="listLong" /label="upshifts" CDS 3313135..3314586 /gene="gerBA" /locus_tag="BSU_35800" /old_locus_tag="BSU35800" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:3110007, 8012571, 10411756, 15774895, 22493018, 23749970, 25681191, 25790435" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3110007, 8012571, 10411756, 15774895, 22493018, 23749970, 25681191, 25790435; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="component of germinant receptor B" /protein_id="NP_391461.2" /db_xref="EnsemblGenomes-Gn:BSU35800" /db_xref="EnsemblGenomes-Tr:CAB15597" /db_xref="GOA:P39569" /db_xref="InterPro:IPR004995" /db_xref="SubtiList:BG10640" /db_xref="UniProtKB/Swiss-Prot:P39569" /translation="MQIDSDLQNNLDTLKKTLGQNDDMMFYTFAFGDSRQKACLLYID GLTENKMLAQYVISPLQKEALAHKECSIEDLSAFFFGFHHSVVSTMKEIEQLVFSGQA ILLADGYRGGLAFDTKSVATRSLDEPSSEVVERGPKIGFIEKLRTNTALLRERTSDPN LVIKEMTLGKRTKKKIAVAYIQDIAPDYVVKEVFKRLKSVNIDNLPESGTLEQLIEDE PFSIFPTILSTERPDRVESSLLEGRVSILVDGTPFALIVPATVDEFIHSPDDYSQRWI PMSLVRLLRYSSILITIYLPGLYISLVSFHTGLLPTRMAISIAGSRLNVPFPPFVEAF IMIFTIELIREAGLRLPKPIGQTIGLIGGVVIGQAAVQAQIVSALMVIVVSVTALASF TVPSYAYNFPLRIIRIGVMISATALGMYGVIMVYLFVIGHLMRLKSFGQDYIIPIMAQ PGQDLKDTVIRIPTMFLKRRPTRNDPEDNIRQR*" /label="gerBA CDS" gene 3313135..3314586 /gene="gerBA" /locus_tag="BSU_35800" /old_locus_tag="BSU35800" /label="gerBA gene" CDS 3314592..3315698 /gene="gerBB" /locus_tag="BSU_35810" /old_locus_tag="BSU35810" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:15774895, 15849754, 16352818, 16850406, 22493018" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15774895, 15849754, 16352818, 16850406, 22493018; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="component of germinant receptor B" /protein_id="NP_391462.2" /db_xref="EnsemblGenomes-Gn:BSU35810" /db_xref="EnsemblGenomes-Tr:CAB15598" /db_xref="GOA:P39570" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004761" /db_xref="SubtiList:BG10641" /db_xref="UniProtKB/Swiss-Prot:P39570" /translation="MRKSEHKLTFMQTLIMISSTLIGAGVLTLPRSAAETGSPSGWLM ILLQGVIFIIIVLLFLPFLQKNSGKTLFKLNSIVAGKFIGFLLNLYICLYFIGIVCFQ ARILGEVVGFFLLKNTPMAVVVFIFLAVAIYHVGGGVYSIAKVYAYIFPITLIIFMML LMFSFRLFQLDFIRPVFEGGYQSFFSLFPKTLLYFSGFEIIFYLVPFMRDPKQVKKAV ALGIATSTLFYSITLLIVIGCMTVAEAKTVTWPTISLIHALEVPGIFIERFDLFLQLT WTAQQFACMLGSFKGAHIGLTEIFHLKNKNNAWLLTAMLAATFFITMYPKDLNDVFYY GTLLGYAFLIVITIPFFVWFLSWIQKKIGRGQLQ*" /label="gerBB CDS" gene 3314592..3315698 /gene="gerBB" /locus_tag="BSU_35810" /old_locus_tag="BSU35810" /label="gerBB gene" CDS 3315695..3316819 /gene="gerBC" /locus_tag="BSU_35820" /old_locus_tag="BSU35820" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:15774895, 15849754, 16352818, 16850406, 20654628, 21685283, 22493018" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15774895, 15849754, 16352818, 16850406, 20654628, 21685283, 22493018; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="lipoprotein component of the germination receptor B" /protein_id="NP_391463.1" /db_xref="EnsemblGenomes-Gn:BSU35820" /db_xref="EnsemblGenomes-Tr:CAB15599" /db_xref="GOA:P39571" /db_xref="InterPro:IPR008844" /db_xref="PDB:3N54" /db_xref="SubtiList:BG10642" /db_xref="UniProtKB/Swiss-Prot:P39571" /translation="MKTASKFSVMFFMLLALCGCWDVKDIEQLSFARGLAIDETNDHQ YKLTYQNLLPQSEDSQASGKPEFVNVTSHGKTILEAVSDVSIKDPPVYSDHLKVILLG EKLMRNQNVDQVLNHFIRDDELRRSSYLMAARGNAADVFTKGNPNQQQPMPSEKLIDL TTHSGYNGKIMIPLRIGRASVYSQNGYSYLIQAVKNEKGKAKYDGAGIIKRGSNKLVG FLSADETQTLSWVMGTIQGGVMPTTDKGHPITFEIKKSKTKIKPVIENGKPVFHISVK TKGILTEDQNPNENSFSKSYLHRLENIFEKKLERDVKQVMDKLQHEYKTDPVFLSDHI RIQHPDYWNKVKGHWDEIFSETDFKYDISFKIINFGTVGK*" /label="gerBC CDS" gene 3315695..3316819 /gene="gerBC" /locus_tag="BSU_35820" /old_locus_tag="BSU35820" /label="gerBC gene" S_feature complement(3315922..3316816) /Source="Nicolas_S_feature" /locus_tag="new_3691599_3692493_c" /HighExp="Etha, Sw, Salt, Heat, S8, B36, Gly, S7, LPhT, S6" /AntisenseName="gerBC" /AntisenseCor="0.12062795031199899" /AntisenseRegPval="-1.3" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1378" downshifts 3316809 /Source="Nicolas_upshifts" /id="D1851" /incds=0 /nref=18 /ntot=72 /MaxReadThrough="0.37711" /MaxDrop="4.85405" /score="35.6875936" /energy="-14.9" /TU="NA" /idTUdmin="U2807" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3316856..3318229) /gene="ywtG" /locus_tag="BSU_35830" /old_locus_tag="BSU35830" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative carbohydrate/proton transporter" /protein_id="NP_391464.2" /db_xref="EnsemblGenomes-Gn:BSU35830" /db_xref="EnsemblGenomes-Tr:CAB15600" /db_xref="GOA:C0SPB2" /db_xref="InterPro:IPR003663" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12538" /db_xref="UniProtKB/Swiss-Prot:C0SPB2" /translation="MKKQSNIWLYFFGALGGALYGYDTGVISGAILFMKKELGLNAFT EGLVVSSLLVGAILGSGAAGKLTDRFGRKKAIMAAALLFCIGGLGVALAPNTGVMVLF RIILGLAVGTSTTIVPLYLSELAPKHKRGALSSLNQLMITVGILLSYIVNYIFADAEA WRWMLGLAAVPSLLLLIGILFMPESPRWLFTNGEESKAKKILEKLRGTKDIDQEIHDI KEAEKQDEGGLKELFDPWVRPALIAGLGLAFLQQFIGTNTIIYYAPKTFTNVGFGNSA SILGTVGIGTVNVLMTLVAIKIIDKIGRKPLLLFGNAGMVISLIVLALVNLFFDNTPA ASWTTVICLGVFIVVFAVSWGPVVWVMLPELFPLHVRGIGTGVSTLMLHVGTLIVSLT YPILMEAIGISYLFLIYAAIGIMAFLFVRFKVTETKGRSLEEIEQDLRDKNGQGGAAG KQQTVGT*" /label="ywtG CDS" gene complement(3316856..3318229) /gene="ywtG" /locus_tag="BSU_35830" /old_locus_tag="BSU35830" /label="ywtG gene" downshifts complement(3316861) /Source="Nicolas_upshifts" /id="D1852" /incds=0 /nref=13 /ntot=90 /MaxReadThrough="6.08746" /MaxDrop="3.99424" /score="22.7548183" /energy="-16.7" /TU="U2808" /idTUdmin="U2808" /TUdmin="-900" /isTUend="FALSE" /label="downshifts" S_feature complement(3318230..3318293) /Source="Nicolas_S_feature" /locus_tag="new_3693907_3693970_c" /HighExp="Etha, Salt, Gly, Heat, Sw, LPhT, HiTm, Diami, B60, UNK1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1379" promotor_-10 complement(3318281..3318299) /Source="Nicolas_upshift_promotors" /id="U2808" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=188 /SigmaFactorBS="atgattggaaaacttatgatcagaaaaataaaaaGGTTTAAt ggccggaaaaagaGGCTAAAAGATTTCTAAAAaaatcccacagacaatgtcattgcag c" /listShort="S1379, ywtG, S1378" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3318294) /Source="Nicolas_upshifts" /id="U2808" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=188 /SigmaFactorBS="atgattggaaaacttatgatcagaaaaataaaaaGGTTTAAt ggccggaaaaagaGGCTAAAAGATTTCTAAAAaaatcccacagacaatgtcattgcag c" /listShort="S1379, ywtG, S1378" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3318314..3318320) /Source="Nicolas_upshift_promotors" /id="U2808" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=188 /SigmaFactorBS="atgattggaaaacttatgatcagaaaaataaaaaGGTTTAAt ggccggaaaaagaGGCTAAAAGATTTCTAAAAaaatcccacagacaatgtcattgcag c" /listShort="S1379, ywtG, S1378" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3318380..3318389 /Source="Nicolas_upshift_promotors" /id="U2809" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1659 /SigmaFactorBS="ttttccaatcatttacttgtatttttttcaatgtcgcCGAAA CATTTtacctgctgcgGCGTCCAATATAAGGTgattcagtacattatcgttatcaatt t" /listShort="S1380, ywtF, S1381, ywtE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3318401..3318416 /Source="Nicolas_upshift_promotors" /id="U2809" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1659 /SigmaFactorBS="ttttccaatcatttacttgtatttttttcaatgtcgcCGAAA CATTTtacctgctgcgGCGTCCAATATAAGGTgattcagtacattatcgttatcaatt t" /listShort="S1380, ywtF, S1381, ywtE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3318403..3318523 /Source="Nicolas_S_feature" /locus_tag="new_3694080_3694200" /HighExp="T-0.40H, LBGstat, T-1.10H, T0.30H, Heat, T-1.40H, T1.30H, T1.0H, T0.0H, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1380" upshifts 3318403 /Source="Nicolas_upshifts" /id="U2809" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1659 /SigmaFactorBS="ttttccaatcatttacttgtatttttttcaatgtcgcCGAAA CATTTtacctgctgcgGCGTCCAATATAAGGTgattcagtacattatcgttatcaatt t" /listShort="S1380, ywtF, S1381, ywtE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3318498..3318505 /Source="Nicolas_upshift_promotors" /id="U2810" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.58041958041958" /psig="0.997002997002997" /xcortree=2249 /SigmaFactorBS="tataggaatatttatcgaaaaatgtctttcgagTAGTTGCCc catggcaaatagAATGGTACGCTTCAAATATTaaagaaacgtgaggtattgatatatg g" /listShort="ywtF, S1381, ywtE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3318519..3318538 /Source="Nicolas_upshift_promotors" /id="U2810" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.58041958041958" /psig="0.997002997002997" /xcortree=2249 /SigmaFactorBS="tataggaatatttatcgaaaaatgtctttcgagTAGTTGCCc catggcaaatagAATGGTACGCTTCAAATATTaaagaaacgtgaggtattgatatatg g" /listShort="ywtF, S1381, ywtE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3318525 /Source="Nicolas_upshifts" /id="U2810" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.58041958041958" /psig="0.997002997002997" /xcortree=2249 /SigmaFactorBS="tataggaatatttatcgaaaaatgtctttcgagTAGTTGCCc catggcaaatagAATGGTACGCTTCAAATATTaaagaaacgtgaggtattgatatatg g" /listShort="ywtF, S1381, ywtE" /GFF_Attribute="listLong" /label="upshifts" CDS 3318562..3319530 /gene="tagT" /locus_tag="BSU_35840" /old_locus_tag="BSU35840" /function="12: Regulatory functions" /experiment="publication(s) with functional evidences, PMID:19099556, 22432711, 29107701" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19099556, 22432711, 29107701; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="teichoic acid-peptidoglycan tethering enzyme (LCP component) with transcription regulator domain of capsule synthesis" /protein_id="NP_391465.2" /db_xref="EnsemblGenomes-Gn:BSU35840" /db_xref="EnsemblGenomes-Tr:CAB15601" /db_xref="GOA:Q7WY78" /db_xref="InterPro:IPR004474" /db_xref="PDB:3MEJ" /db_xref="PDB:4DE9" /db_xref="SubtiList:BG12537" /db_xref="UniProtKB/Swiss-Prot:Q7WY78" /translation="MEERSQRRKKKRKLKKWVKVVAGLMAFLVIAAGSVGAYAFVKLN NASKEAHVSLARGEQSVKRIKEFDPGKDSFSVLLLGIDAREKNGETVDQARSDANVLV TFNRKEKTAKMLSIPRDAYVNIPGHGYDKFTHAHAYGGVDLTVKTVEEMLDIPVDYVV ESNFTAFEDVVNELNGVKVTVKSDKVIQQIKKDTKGKVVLQKGTHTLDGEEALAYVRT RKADSDLLRGQRQMEVLSAIIDKSKSLSSIPAYDDIVDTMGQNLKMNLSLKDAIGLFP FITSLKSVESIQLTGYDYEPAGVYYFKLNQQKLQEVKKELQNDLGV*" /label="tagT CDS" gene 3318562..3319530 /gene="tagT" /locus_tag="BSU_35840" /old_locus_tag="BSU35840" /label="tagT gene" downshifts 3319515 /Source="Nicolas_upshifts" /id="D1853" /incds=0 /nref=27 /ntot=139 /MaxReadThrough="6.07699" /MaxDrop="4.78541" /score="17.3040761" /energy="-17.8" /TU="U2809,U2810" /idTUdmin="U2809" /TUdmin="-1012" /isTUend="FALSE" /label="downshifts" promotor_-35 3319574..3319581 /Source="Nicolas_upshift_promotors" /id="U2811" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.667332667332667" /psig="0.982017982017982" /xcortree=1778 /SigmaFactorBS="cgattacgccatcccgttttacatatttcctTGTTGAAAatt atcaaagtaacGTTTAGCCTTAATTTATATGgattatgtttcacaggcaagctgaaca t" /listShort="S1381, ywtE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3319596..3319615 /Source="Nicolas_upshift_promotors" /id="U2811" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.667332667332667" /psig="0.982017982017982" /xcortree=1778 /SigmaFactorBS="cgattacgccatcccgttttacatatttcctTGTTGAAAatt atcaaagtaacGTTTAGCCTTAATTTATATGgattatgtttcacaggcaagctgaaca t" /listShort="S1381, ywtE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3319603..3319685 /Source="Nicolas_S_feature" /locus_tag="new_3695280_3695362" /HighExp="Etha, dia5, Lbtran, dia15, LBGexp, LBGtran, G150, Mt0, G180, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigWXY" /TUshortPSig="0.982, 0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1381" upshifts 3319603 /Source="Nicolas_upshifts" /id="U2811" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.667332667332667" /psig="0.982017982017982" /xcortree=1778 /SigmaFactorBS="cgattacgccatcccgttttacatatttcctTGTTGAAAatt atcaaagtaacGTTTAGCCTTAATTTATATGgattatgtttcacaggcaagctgaaca t" /listShort="S1381, ywtE" /GFF_Attribute="listLong" /label="upshifts" CDS 3319686..3320546 /gene="ribZB" /locus_tag="BSU_35850" /old_locus_tag="BSU35850" /EC_number="3.1.3.-" /function="4.9: Riboflavin, FMN, and FAD" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 26316208; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-amino-6-ribitylamino-2,4(1H, 3H)-pyrimidinedione 5'-phosphate phosphatase (promiscuous activity)" /protein_id="NP_391466.1" /db_xref="EnsemblGenomes-Gn:BSU35850" /db_xref="EnsemblGenomes-Tr:CAB15602" /db_xref="GOA:P96741" /db_xref="InterPro:IPR000150" /db_xref="InterPro:IPR006379" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG12536" /db_xref="UniProtKB/Swiss-Prot:P96741" /translation="MKCIAIDLDGTLLNKESVISAENREAIKRAVDAGILVTICTGRA TFDVKALLDDLDIPIIAANGGTIHDTGYRLISRTLMDQEAGKAIADYLLSKNIYFEVY TDDHLLSPFDGEAKLHAELDILKSANPNEQTDDLWQGAMTQFKQFGIKPIPHIESVFD GGENIYKLLCFSFDMDKLKQAKEELKHHKKLAQTSSGKHIIEILPASSGKGRALTKLA DIYGIETQDIYAIGDSPNDLSMFEVAGHRIAMENAIDELKEKSTFVTKSNDENGVAYF IDQLLSGQYA*" /label="ribZB CDS" gene 3319686..3320546 /gene="ribZB" /locus_tag="BSU_35850" /old_locus_tag="BSU35850" /label="ribZB gene" downshifts 3320527 /Source="Nicolas_upshifts" /id="D1854" /incds=0 /nref=163 /ntot=235 /MaxReadThrough="3.35965" /MaxDrop="5.65658" /score="24.125299" /energy="-9.8" /TU="NA" /idTUdmin="U2809" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3320580..3321821) /gene="pgdS" /locus_tag="BSU_35860" /old_locus_tag="BSU35860" /EC_number="3.4.19.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12073126, 12644511, 16689787, 16952838, 26158264, 28664519" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12073126, 12644511, 16689787, 16952838, 26158264, 28664519; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="gamma-DD-glutamyl hydrolase (PGA depolymerase)" /protein_id="NP_391467.1" /db_xref="EnsemblGenomes-Gn:BSU35860" /db_xref="EnsemblGenomes-Tr:CAB15603" /db_xref="GOA:P96740" /db_xref="InterPro:IPR000064" /db_xref="SubtiList:BG12535" /db_xref="UniProtKB/Swiss-Prot:P96740" /translation="MNTLANWKKFLLVAVIICFLVPIMTKAEIAEADTSSELIVSEAK NLLGYQYKYGGETPKEGFDPSGLIQYVFSKADIHLPRSVNDQYKIGTAVKPENLKPGD ILFFKKEGSTGTVPTHDALYIGDGQMVHSTQSKGVIITNYKKSSYWSGTYIGARRIAA DPATADVPVVQEAEKYIGVPYVFGGSTPSEGFDCSGLVQYVFQQALGIYLPRSAEQQW AVGEKVAPQNIKPGDVVYFSNTYKTGISHAGIYAGAGRFIQASRSEKVTISYLSEDYW KSKMTGIRRFDNLTIPKENPIVSEATLYVGEVPYKQGGVTPETGFDTAGFVQYVYQKA AGISLPRYATSQYNAGTKIEKADLKPGDIVFFQSTSLNPSIYIGNGQVVHVTLSNGVT ITNMNTSTYWKDKYAGSIRVQ*" /label="pgdS CDS" gene complement(3320580..3321821) /gene="pgdS" /locus_tag="BSU_35860" /old_locus_tag="BSU35860" /label="pgdS gene" downshifts complement(3320599) /Source="Nicolas_upshifts" /id="D1855" /incds=0 /nref=228 /ntot=317 /MaxReadThrough="2.27329" /MaxDrop="7.15996" /score="10.2499259" /energy="-9.8" /TU="NA" /idTUdmin="U2812" /TUdmin="-18" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3321843..3321861) /Source="Nicolas_upshift_promotors" /id="U2812" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2804 /SigmaFactorBS="ttatttgcccagcatattcattctgtaaaaatattaaaaagt ctCTTAACATattcaaaaaaatACCGATGTTAAAACTGCAAaaagaggaggagataat a" /listShort="pgdS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3321865) /Source="Nicolas_upshifts" /id="U2812" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2804 /SigmaFactorBS="ttatttgcccagcatattcattctgtaaaaatattaaaaagt ctCTTAACATattcaaaaaaatACCGATGTTAAAACTGCAAaaagaggaggagataat a" /listShort="pgdS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3321874..3321881) /Source="Nicolas_upshift_promotors" /id="U2812" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2804 /SigmaFactorBS="ttatttgcccagcatattcattctgtaaaaatattaaaaagt ctCTTAACATattcaaaaaaatACCGATGTTAAAACTGCAAaaagaggaggagataat a" /listShort="pgdS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3321962..3322129) /gene="edmS" /locus_tag="BSU_35870" /old_locus_tag="BSU35870" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16267300, 16689787, 20812257, 21357437, 23583563, 25843804" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16267300, 16689787, 20812257, 21357437, 23583563, 25843804; Product type f : factor" /codon_start=1 /transl_table=11 /product="factor required extrachromosomal elements maintenance" /protein_id="NP_391468.1" /db_xref="EnsemblGenomes-Gn:BSU35870" /db_xref="EnsemblGenomes-Tr:CAB15604" /db_xref="SubtiList:BG12534" /db_xref="UniProtKB/Swiss-Prot:P96739" /translation="MKFVKAIWPFVAVAIVFMFMSAFKFNDQLTDQEKQKIDMEMNKI QQQEEPVNANK*" /label="edmS CDS" gene complement(3321962..3322129) /gene="edmS" /locus_tag="BSU_35870" /old_locus_tag="BSU35870" /label="edmS gene" downshifts complement(3321989) /Source="Nicolas_upshifts" /id="D1856" /incds=0 /nref=1 /ntot=47 /MaxReadThrough="0.6752" /MaxDrop="2.78178" /score="24.9141523" /energy="-14.7" /TU="NA" /idTUdmin="U2812" /TUdmin="-1408" /isTUend="FALSE" /label="downshifts" CDS complement(3322144..3323286) /gene="capA" /locus_tag="BSU_35880" /old_locus_tag="BSU35880" /EC_number="6.3.2.-" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11606194, 11751809, 12644511, 16689787, 19745567, 27818647" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11606194, 11751809, 12644511, 16689787, 19745567, 27818647; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="capsular polyglutamate synthetase (acid resistance)" /protein_id="NP_391469.1" /db_xref="EnsemblGenomes-Gn:BSU35880" /db_xref="EnsemblGenomes-Tr:CAB15605" /db_xref="InterPro:IPR019079" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG12533" /db_xref="UniProtKB/Swiss-Prot:P96738" /translation="MKKELSFHEKLLKLTKQQKKKTNKHVFIAIPIVFVLMFAFMWAG KAETPKVKTYSDDVLSASFVGDIMMGRYVEKVTEQKGADSIFQYVEPIFRASDYVAGN FENPVTYQKNYKQADKEIHLQTNKESVKVLKDMNFTVLNSANNHAMDYGVQGMKDTLG EFAKQNLDIVGAGYSLSDAKKKISYQKVNGVTIATLGFTDVSGKGFAAKKNTPGVLPA DPEIFIPMISEAKKHADIVVVQSHWGQEYDNDPNDRQRQLARAMSDAGADIIVGHHPH VLEPIEVYNGTVIFYSLGNFVFDQGWTRTRDSALVQYHLKKNGTGRFEVTPIDIHEAT PAPVKKDSLKQKTIIRELTKDSNFAWKVEDGKLTFDIDHSDKLKSK*" /label="capA CDS" gene complement(3322144..3323286) /gene="capA" /locus_tag="BSU_35880" /old_locus_tag="BSU35880" /label="capA gene" CDS complement(3323305..3323754) /gene="capC" /locus_tag="BSU_35890" /old_locus_tag="BSU35890" /EC_number="6.3.2.-" /function="16.13: Shape" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11606194, 11751809, 15849754, 16689787, 16850406, 19734658" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11606194, 11751809, 15849754, 16689787, 16850406, 19734658; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="capsular polyglutamate amide ligase/translocase subunit" /protein_id="NP_391470.1" /db_xref="EnsemblGenomes-Gn:BSU35890" /db_xref="EnsemblGenomes-Tr:CAB15606" /db_xref="GOA:P96737" /db_xref="InterPro:IPR008338" /db_xref="SubtiList:BG12532" /db_xref="UniProtKB/Swiss-Prot:P96737" /translation="MFGSDLYIALILGVLLSLIFAEKTGIVPAGLVVPGYLGLVFNQP VFILLVLLVSLLTYVIVKYGLSKFMILYGRRKFAAMLITGIVLKIAFDFLYPIVPFEI AEFRGIGIIVPGLIANTIQKQGLTITFGSTLLLSGATFAIMFVYYLI*" /label="capC CDS" gene complement(3323305..3323754) /gene="capC" /locus_tag="BSU_35890" /old_locus_tag="BSU35890" /label="capC gene" promotor_-35 3323448..3323454 /Source="Nicolas_upshift_promotors" /id="U2813" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.853146853146853" /psig="0.853146853146853" /xcortree=131 /SigmaFactorBS="ttggcaattaaacctggcacgatgatgccgattcctcgaaat tctgCGATTTCaaatggtacaatcGGGTATAGAAAATCAAACGcgatttttaggacga t" /listShort="S1382" /listLong="rbsR, rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /label="promotor_-35" upshifts 3323462 /Source="Nicolas_upshifts" /id="U2813" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.853146853146853" /psig="0.853146853146853" /xcortree=131 /SigmaFactorBS="ttggcaattaaacctggcacgatgatgccgattcctcgaaat tctgCGATTTCaaatggtacaatcGGGTATAGAAAATCAAACGcgatttttaggacga t" /listShort="S1382" /listLong="rbsR, rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /label="upshifts" promotor_-10 3323468..3323486 /Source="Nicolas_upshift_promotors" /id="U2813" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.853146853146853" /psig="0.853146853146853" /xcortree=131 /SigmaFactorBS="ttggcaattaaacctggcacgatgatgccgattcctcgaaat tctgCGATTTCaaatggtacaatcGGGTATAGAAAATCAAACGcgatttttaggacga t" /listShort="S1382" /listLong="rbsR, rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /label="promotor_-10" S_feature 3323475..3325684 /Source="Nicolas_S_feature" /locus_tag="new_3699152_3701361" /HighExp="Sw, Salt, dia5, BC, B60, Diami, Lbstat, H2O2, dia15, Gly" /AntisenseName="pgsB" /AntisenseCor="7.6745622610153399E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="0.40410200000000002" /TUshortSig="SigB" /TUshortPSig="0.853" /TUlongSig="NA" /TUlongPSig="NA" /label="S1382" CDS complement(3323769..3324950) /gene="capB" /locus_tag="BSU_35900" /old_locus_tag="BSU35900" /EC_number="6.3.2.-" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11606194, 11751809, 12644511, 16689787, 19420703, 19734658, 27446033; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="capsular polyglutamate synthetase (ATP-dependentamide ligase)" /protein_id="NP_391471.2" /db_xref="EnsemblGenomes-Gn:BSU35900" /db_xref="EnsemblGenomes-Tr:CAB15607" /db_xref="GOA:P96736" /db_xref="InterPro:IPR008337" /db_xref="InterPro:IPR013221" /db_xref="InterPro:IPR036565" /db_xref="SubtiList:BG12531" /db_xref="UniProtKB/Swiss-Prot:P96736" /translation="MWLLIIACAVILVIGILEKRRHQKNIDALPVRVNINGIRGKSTV TRLTTGILIEAGYKTVGKTTGTDARMIYWDTPEEKPIKRKPQGPNIGEQKEVMRETVE RGANAIVSECMAVNPDYQIIFQEELLQANIGVIVNVLEDHMDVMGPTLDEIAEAFTAT IPYNGHLVITDSEYTEFFKQKAKERNTKVIIADNSKITDEYLRKFEYMVFPDNASLAL GVAQALGIDEETAFKGMLNAPPDPGAMRILPLISPSEPGHFVNGFAANDASSTLNIWK RVKEIGYPTDDPIIIMNCRADRVDRTQQFANDVLPYIEASELILIGETTEPIVKAYEE GKIPADKLHDLEYKSTDEIMELLKKRMHNRVIYGVGNIHGAAEPLIEKIHEYKVKQLV S*" /label="capB CDS" gene complement(3323769..3324950) /gene="capB" /locus_tag="BSU_35900" /old_locus_tag="BSU35900" /label="capB gene" promotor_-35 3325664..3325671 /Source="Nicolas_upshift_promotors" /id="U2814" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig=1 /xcortree=326 /SigmaFactorBS="atatatacaatttacaattagatttcttttgatattttTATT GCTAacttcggattgttcaTGATAATCTATCTATGTAAAcggttacataaacaaggag g" /listShort="rbsR, rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3325686 /Source="Nicolas_upshifts" /id="U2814" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig=1 /xcortree=326 /SigmaFactorBS="atatatacaatttacaattagatttcttttgatattttTATT GCTAacttcggattgttcaTGATAATCTATCTATGTAAAcggttacataaacaaggag g" /listShort="rbsR, rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3325687..3325706 /Source="Nicolas_upshift_promotors" /id="U2814" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig=1 /xcortree=326 /SigmaFactorBS="atatatacaatttacaattagatttcttttgatattttTATT GCTAacttcggattgttcaTGATAATCTATCTATGTAAAcggttacataaacaaggag g" /listShort="rbsR, rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3325707) /Source="Nicolas_upshifts" /id="U2815" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=694 /SigmaFactorBS="ccgccgctccggcgacatctttaattgtaGCCAAaacagctC CTCCTTGTTTATGTaaccgtttacatagatagattatcatgaacaatccgaagttagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3325712..3325726) /Source="Nicolas_upshift_promotors" /id="U2815" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=694 /SigmaFactorBS="ccgccgctccggcgacatctttaattgtaGCCAAaacagctC CTCCTTGTTTATGTaaccgtttacatagatagattatcatgaacaatccgaagttagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3325734..3325738) /Source="Nicolas_upshift_promotors" /id="U2815" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=694 /SigmaFactorBS="ccgccgctccggcgacatctttaattgtaGCCAAaacagctC CTCCTTGTTTATGTaaccgtttacatagatagattatcatgaacaatccgaagttagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3325734..3326714 /gene="rbsR" /locus_tag="BSU_35910" /old_locus_tag="BSU35910" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11750820, 16519689" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11750820, 16519689; Product type r: regulator" /codon_start=1 /transl_table=11 /product="ribose operon repressor (LacI family, D-ribose)" /protein_id="NP_391472.1" /db_xref="EnsemblGenomes-Gn:BSU35910" /db_xref="EnsemblGenomes-Tr:CAB15608" /db_xref="GOA:P36944" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG10876" /db_xref="UniProtKB/Swiss-Prot:P36944" /translation="MATIKDVAGAAGVSVATVSRNLNDNGYVHEETRTRVIAAMAKLN YYPNEVARSLYKRESRLIGLLLPDITNPFFPQLARGAEDELNREGYRLIFGNSDEELK KELEYLQTFKQNHVAGIIAATNYPDLEEYSGMNYPVVFLDRTLEGAPSVSSDGYTGVK LAAQAIIHGKSQRITLLRGPAHLPTAQDRFNGALEILKQAEVDFQVIETASFSIKDAQ SMAKELFASYPATDGVIASNDIQAAAVLHEALRRGKNVPEDIQIIGYDDIPQSGLLFP PLSTIKQPAYDMGKEAAKLLLGIIKKQPLAETAIQMPVTYIGRKTTRKED*" /label="rbsR CDS" gene 3325734..3326714 /gene="rbsR" /locus_tag="BSU_35910" /old_locus_tag="BSU35910" /label="rbsR gene" promotor_-35 3326563..3326570 /Source="Nicolas_upshift_promotors" /id="U2816" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.759240759240759" /xcortree=1571 /SigmaFactorBS="cgcaaagcggacttctgttcccgcCACTTTCTacaattaaac agcCCGCATATGATATGGGGAAAgaagctgccaaactgcttttgggtatcattaaaaa a" /listShort="rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3326584..3326603 /Source="Nicolas_upshift_promotors" /id="U2816" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.759240759240759" /xcortree=1571 /SigmaFactorBS="cgcaaagcggacttctgttcccgcCACTTTCTacaattaaac agcCCGCATATGATATGGGGAAAgaagctgccaaactgcttttgggtatcattaaaaa a" /listShort="rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3326599 /Source="Nicolas_upshifts" /id="U2816" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.759240759240759" /xcortree=1571 /SigmaFactorBS="cgcaaagcggacttctgttcccgcCACTTTCTacaattaaac agcCCGCATATGATATGGGGAAAgaagctgccaaactgcttttgggtatcattaaaaa a" /listShort="rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /GFF_Attribute="listLong" /label="upshifts" CDS 3326716..3327597 /gene="rbsK" /locus_tag="BSU_35920" /old_locus_tag="BSU35920" /EC_number="2.7.1.15" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7921236, 16978644; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribokinase" /protein_id="NP_391473.1" /db_xref="EnsemblGenomes-Gn:BSU35920" /db_xref="EnsemblGenomes-Tr:CAB15609" /db_xref="GOA:P36945" /db_xref="InterPro:IPR002139" /db_xref="InterPro:IPR002173" /db_xref="InterPro:IPR011611" /db_xref="InterPro:IPR011877" /db_xref="InterPro:IPR029056" /db_xref="SubtiList:BG10877" /db_xref="UniProtKB/Swiss-Prot:P36945" /translation="MRNICVIGSCSMDLVVTSDKRPKAGETVLGTSFQTVPGGKGANQ AVAAARLGAQVFMVGKVGDDHYGTAILNNLKANGVRTDYMEPVTHTESGTAHIVLAEG DNSIVVVKGANDDITPAYALNALEQIEKVDMVLIQQEIPEETVDEVCKYCHSHDIPII LNPAPARPLKQETIDHATYLTPNEHEASILFPELTISEALALYPAKLFITEGKQGVRY SAGSKEVLIPSFPVEPVDTTGAGDTFNAAFAVALAEGKDIEAALRFANRAASLSVCSF GAQGGMPTRNEVEELLS*" /label="rbsK CDS" gene 3326716..3327597 /gene="rbsK" /locus_tag="BSU_35920" /old_locus_tag="BSU35920" /label="rbsK gene" CDS 3327594..3327989 /gene="rbsD" /locus_tag="BSU_35930" /old_locus_tag="BSU35930" /EC_number="5.4.99.62" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7921236, 12738765, 21276853; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-ribose pyranase" /protein_id="NP_391474.1" /db_xref="EnsemblGenomes-Gn:BSU35930" /db_xref="EnsemblGenomes-Tr:CAB15610" /db_xref="GOA:P36946" /db_xref="InterPro:IPR007721" /db_xref="InterPro:IPR023064" /db_xref="InterPro:IPR023750" /db_xref="PDB:1OGC" /db_xref="PDB:1OGD" /db_xref="PDB:1OGE" /db_xref="PDB:1OGF" /db_xref="SubtiList:BG10878" /db_xref="UniProtKB/Swiss-Prot:P36946" /translation="MKKHGILNSHLAKILADLGHTDKIVIADAGLPVPDGVLKIDLSL KPGLPAFQDTAAVLAEEMAVEKVIAAAEIKASNQENAKFLENLFSEQEIEYLSHEEFK LLTKDAKAVIRTGEFTPYANCILQAGVLF*" /label="rbsD CDS" gene 3327594..3327989 /gene="rbsD" /locus_tag="BSU_35930" /old_locus_tag="BSU35930" /label="rbsD gene" CDS 3328005..3329486 /gene="rbsA" /locus_tag="BSU_35940" /old_locus_tag="BSU35940" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7921236" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7921236; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ribose ABC transporter (ATP-binding protein)" /protein_id="NP_391475.1" /db_xref="EnsemblGenomes-Gn:BSU35940" /db_xref="EnsemblGenomes-Tr:CAB15611" /db_xref="GOA:P36947" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR015861" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10879" /db_xref="UniProtKB/Swiss-Prot:P36947" /translation="MQIEMKDIHKTFGKNQVLSGVSFQLMPGEVHALMGENGAGKSTL MNILTGLHKADKGQISINGNETYFSNPKEAEQHGIAFIHQELNIWPEMTVLENLFIGK EISSKLGVLQTRKMKALAKEQFDKLSVSLSLDQEAGECSVGQQQMIEIAKALMTNAEV IIMDEPTAALTEREISKLFEVITALKKNGVSIVYISHRMEEIFAICDRITIMRDGKTV DTTNISETDFDEVVKKMVGRELTERYPKRTPSLGDKVFEVKNASVKGSFEDVSFYVRS GEIVGVSGLMGAGRTEMMRALFGVDRLDTGEIWIAGKKTAIKNPQEAVKKGLGFITEN RKDEGLLLDTSIRENIALPNLSSFSPKGLIDHKREAEFVDLLIKRLTIKTASPETHAR HLSGGNQQKVVIAKWIGIGPKVLILDEPTRGVDVGAKREIYTLMNELTERGVAIIMVS SELPEILGMSDRIIVVHEGRISGEIHAREATQERIMTLATGGR*" /label="rbsA CDS" gene 3328005..3329486 /gene="rbsA" /locus_tag="BSU_35940" /old_locus_tag="BSU35940" /label="rbsA gene" CDS 3329488..3330456 /gene="rbsC" /locus_tag="BSU_35950" /old_locus_tag="BSU35950" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7921236, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7921236, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ribose ABC transporter (permease)" /protein_id="NP_391476.1" /db_xref="EnsemblGenomes-Gn:BSU35950" /db_xref="EnsemblGenomes-Tr:CAB15612" /db_xref="GOA:P36948" /db_xref="InterPro:IPR001851" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG10880" /db_xref="UniProtKB/Swiss-Prot:P36948" /translation="MKTEQLQTEQKRIHFDGVMQKLGPFLGLFILVIIVSILNPSFLE PLNILNLLRQVAINGLIAFGMTFVILTGGIDLSVGAILALSSALVAGMIVSGVDPVLA IILGCIIGAVLGMINGLLITKGKMAPFIATLATMTVFRGLTLVYTDGNPITGLGTNYG FQMFGRGYFLGIPVPAITMVLAFVILWVLLHKTPFGRRTYAIGGNEKAALISGIKVTR VKVMIYSLAGLLSALAGAILTSRLHSAQPTAGESYELDAIAAVVLGGTSLSGGRGRIV GTLIGVLIIGTLNNGLNLLGVSSFYQLVVKGIVILIAVLLDRKKSA*" /label="rbsC CDS" gene 3329488..3330456 /gene="rbsC" /locus_tag="BSU_35950" /old_locus_tag="BSU35950" /label="rbsC gene" CDS 3330468..3331385 /gene="rbsB" /locus_tag="BSU_35960" /old_locus_tag="BSU35960" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7921236" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7921236; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ribose ABC transporter (ribose-binding lipoprotein)" /protein_id="NP_391477.1" /db_xref="EnsemblGenomes-Gn:BSU35960" /db_xref="EnsemblGenomes-Tr:CAB15613" /db_xref="GOA:P36949" /db_xref="InterPro:IPR025997" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG10881" /db_xref="UniProtKB/Swiss-Prot:P36949" /translation="MKKAVSVILTLSLFLLTACSLEPPQWAKPSNSGNKKEFTIGLSV STLNNPFFVSLKKGIEKEAKKRGMKVIIVDAQNDSSKQTSDVEDLIQQGVDALLINPT DSSAISTAVESANAVGVPVVTIDRSAEQGKVETLVASDNVKGGEMAAAFIADKLGKGA KVAELEGVPGASATRERGSGFHNIADQKLQVVTKQSADFDRTKGLTVMENLLQGHPDI QAVFAHNDEMALGALEAINSSGKDILVIGFDGNKDALASIKDRKLSATVAQQPELIGK LATEAADDILHGKKVQKTISAPLKLETQK*" /label="rbsB CDS" gene 3330468..3331385 /gene="rbsB" /locus_tag="BSU_35960" /old_locus_tag="BSU35960" /label="rbsB gene" promotor_-35 3331394..3331400 /Source="Nicolas_upshift_promotors" /id="U2817" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=144 /SigmaFactorBS="cgcctctcaaactagaaacacaaaaataattgtctgaTGTTT AGgaacctgcgataacGTGAATAGAGATATAGAATgaattatttctcttacgtgagga g" /listShort="ywsB, S1383, ywsA, S1384" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3331415..3331433 /Source="Nicolas_upshift_promotors" /id="U2817" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=144 /SigmaFactorBS="cgcctctcaaactagaaacacaaaaataattgtctgaTGTTT AGgaacctgcgataacGTGAATAGAGATATAGAATgaattatttctcttacgtgagga g" /listShort="ywsB, S1383, ywsA, S1384" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3331417 /Source="Nicolas_upshifts" /id="U2817" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=144 /SigmaFactorBS="cgcctctcaaactagaaacacaaaaataattgtctgaTGTTT AGgaacctgcgataacGTGAATAGAGATATAGAATgaattatttctcttacgtgagga g" /listShort="ywsB, S1383, ywsA, S1384" /GFF_Attribute="listLong" /label="upshifts" CDS 3331467..3332003 /gene="ywsB" /locus_tag="BSU_35970" /old_locus_tag="BSU35970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15187182; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative cell wall binding enzyme" /protein_id="NP_391478.1" /db_xref="EnsemblGenomes-Gn:BSU35970" /db_xref="EnsemblGenomes-Tr:CAB15614" /db_xref="GOA:P96729" /db_xref="InterPro:IPR003646" /db_xref="InterPro:IPR036028" /db_xref="SubtiList:BG12530" /db_xref="UniProtKB/Swiss-Prot:P96729" /translation="MNKPTKLFSTLALAAGMTAAAAGGAGTIHAQQPETTVSIDDLYS YPIDSYLVSAEALNVRTKPSASSQKADTLHLGDSLKLISFSNADWAKVKYKNGKTGFV STHYIVKAATTVKTKTKTKVYTSADGKSIKTLPADTSVSFLGWSKTNKGGFDFDWVFV DYGGTTGYMKTKDLHMTK*" /label="ywsB CDS" gene 3331467..3332003 /gene="ywsB" /locus_tag="BSU_35970" /old_locus_tag="BSU35970" /label="ywsB gene" downshifts 3331986 /Source="Nicolas_upshifts" /id="D1857" /incds=0 /nref=187 /ntot=255 /MaxReadThrough="5.87246" /MaxDrop="7.38203" /score="26.4284327" /energy="-19" /TU="U2817" /idTUdmin="U2814" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" S_feature 3332031..3332141 /Source="Nicolas_S_feature" /locus_tag="new_3707708_3707818" /HighExp="Etha, M9-stat, Sw, M40t90, G150, B60, T0.30H, M0t90, T1.30H, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S1383" promotor_-35 3332110..3332116 /Source="Nicolas_upshift_promotors" /id="U2818" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=889 /SigmaFactorBS="atattgtcgtatgctgtgtcgaaacctTACATGAtcatcgac atttttGTTCACGCTAAAaagcggaggtgtaaatatggatcaatttgaagcagcatat g" /listShort="ywsA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3332131..3332142 /Source="Nicolas_upshift_promotors" /id="U2818" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=889 /SigmaFactorBS="atattgtcgtatgctgtgtcgaaacctTACATGAtcatcgac atttttGTTCACGCTAAAaagcggaggtgtaaatatggatcaatttgaagcagcatat g" /listShort="ywsA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3332143 /Source="Nicolas_upshifts" /id="U2818" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=889 /SigmaFactorBS="atattgtcgtatgctgtgtcgaaacctTACATGAtcatcgac atttttGTTCACGCTAAAaagcggaggtgtaaatatggatcaatttgaagcagcatat g" /listShort="ywsA" /GFF_Attribute="listLong" /label="upshifts" CDS 3332159..3332455 /gene="ywsA" /locus_tag="BSU_35980" /old_locus_tag="BSU35980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11782522" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391479.1" /db_xref="EnsemblGenomes-Gn:BSU35980" /db_xref="EnsemblGenomes-Tr:CAB15615" /db_xref="InterPro:IPR024997" /db_xref="SubtiList:BG12529" /db_xref="UniProtKB/Swiss-Prot:P96728" /translation="MDQFEAAYESYKARQTTADQENVPSGKEEIIAVRRNEEDNIIAV KTNTGRELDYPTALSEAKSGKLAHVDVFHKYGRDILRSEPDGIKENNLSELPDF*" /label="ywsA CDS" gene 3332159..3332455 /gene="ywsA" /locus_tag="BSU_35980" /old_locus_tag="BSU35980" /label="ywsA gene" S_feature 3332456..3333108 /Source="Nicolas_S_feature" /locus_tag="new_3708133_3708785" /HighExp="Etha, M9-stat, S5, S7, S6, Sw, S8, B60, G150, S4" /AntisenseName="ywrO" /AntisenseCor="-0.23279201478213099" /AntisenseRegPval="-3.9" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S1384" CDS complement(3332495..3333022) /gene="ywrO" /locus_tag="BSU_35990" /old_locus_tag="BSU35990" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 11782522, 14697229, 17768344; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nitroreductase (unknown substrate)" /protein_id="NP_391480.1" /db_xref="EnsemblGenomes-Gn:BSU35990" /db_xref="EnsemblGenomes-Tr:CAB15616" /db_xref="GOA:P80871" /db_xref="InterPro:IPR003680" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG12528" /db_xref="UniProtKB/Swiss-Prot:P80871" /translation="MKILVLAVHPHMETSVVNKAWAEELSKHDNITVRDLYKEYPDEA IDVAKEQQLCEEYDRIVFQFPLYWYSSPPLLKKWQDLVLTYGWAFGSEGNALHGKELM LAVSTGSEAEKYQAGGANHYSISELLKPFQATSNLIGMKYLPPYVFYGVNYAAAEDIS HSAKRLAEYIQQPFV*" /label="ywrO CDS" gene complement(3332495..3333022) /gene="ywrO" /locus_tag="BSU_35990" /old_locus_tag="BSU35990" /label="ywrO gene" downshifts complement(3332505) /Source="Nicolas_upshifts" /id="D1858" /incds=0 /nref=48 /ntot=208 /MaxReadThrough="3.48831" /MaxDrop="4.56453" /score="1.41593376" /energy="-17.4" /TU="U2819" /idTUdmin="U2821" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3333042..3333061) /Source="Nicolas_upshift_promotors" /id="U2819" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.603396603396603" /psig=1 /xcortree=1963 /SigmaFactorBS="aaaagaaagccccttttagcagggctttcttttTATTTGGCt cttttcctgattTTAGATAAAATAACATCAAAacagtaaaggtgtggtctgatgaaaa t" /listShort="ywrO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3333055) /Source="Nicolas_upshifts" /id="U2819" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.603396603396603" /psig=1 /xcortree=1963 /SigmaFactorBS="aaaagaaagccccttttagcagggctttcttttTATTTGGCt cttttcctgattTTAGATAAAATAACATCAAAacagtaaaggtgtggtctgatgaaaa t" /listShort="ywrO" /GFF_Attribute="listLong" /label="upshifts" downshifts 3333066 /Source="Nicolas_upshifts" /id="D1859" /incds=0 /nref=26 /ntot=56 /MaxReadThrough="0.805200000000001" /MaxDrop="4.7199" /score="10.409416" /energy="-6.8" /TU="NA" /idTUdmin="U2817" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 complement(3333075..3333082) /Source="Nicolas_upshift_promotors" /id="U2819" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.603396603396603" /psig=1 /xcortree=1963 /SigmaFactorBS="aaaagaaagccccttttagcagggctttcttttTATTTGGCt cttttcctgattTTAGATAAAATAACATCAAAacagtaaaggtgtggtctgatgaaaa t" /listShort="ywrO" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3333121) /Source="Nicolas_upshifts" /id="D1860" /incds=0 /nref=20 /ntot=149 /MaxReadThrough="4.85403" /MaxDrop="6.46739" /score="-8.02974492" /energy="-5" /TU="U2821" /idTUdmin="U2821" /TUdmin="-616" /isTUend="FALSE" /label="downshifts" CDS complement(3333122..3333889) /gene="alsD" /locus_tag="BSU_36000" /old_locus_tag="BSU36000" /EC_number="4.1.1.5" /function="16.8: Protect" /function="16.14: Store" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7685336, 10972805, 12363365, 17183216, 21531833, 26454865" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7685336, 10972805, 12363365, 17183216, 21531833, 26454865; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="alpha-acetolactate decarboxylase" /protein_id="NP_391481.1" /db_xref="EnsemblGenomes-Gn:BSU36000" /db_xref="EnsemblGenomes-Tr:CAB15617" /db_xref="GOA:Q04777" /db_xref="InterPro:IPR005128" /db_xref="SubtiList:BG10472" /db_xref="UniProtKB/Swiss-Prot:Q04777" /translation="MKRESNIQVLSRGQKDQPVSQIYQVSTMTSLLDGVYDGDFELSE IPKYGDFGIGTFNKLDGELIGFDGEFYRLRSDGTATPVQNGDRSPFCSFTFFTPDMTH KIDAKMTREDFEKEINSMLPSRNLFYAIRIDGLFKKVQTRTVELQEKPYVPMVEAVKT QPIFNFDNVRGTIVGFLTPAYANGIAVSGYHLHFIDEGRNSGGHVFDYVLEDCTVTIS QKMNMNLRLPNTADFFNANLDNPDFAKDIETTEGSPE*" /label="alsD CDS" gene complement(3333122..3333889) /gene="alsD" /locus_tag="BSU_36000" /old_locus_tag="BSU36000" /label="alsD gene" CDS complement(3333951..3335663) /gene="alsS" /locus_tag="BSU_36010" /old_locus_tag="BSU36010" /EC_number="2.2.1.6" /function="16.8: Protect" /function="16.14: Store" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10972805, 12363365, 17183216, 7685336, 25393087, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10972805, 12363365, 17183216, 7685336, 25393087, 25355936; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="alpha-acetolactate synthase" /protein_id="NP_391482.2" /db_xref="EnsemblGenomes-Gn:BSU36010" /db_xref="EnsemblGenomes-Tr:CAB15618" /db_xref="GOA:Q04789" /db_xref="InterPro:IPR000399" /db_xref="InterPro:IPR011766" /db_xref="InterPro:IPR012000" /db_xref="InterPro:IPR012001" /db_xref="InterPro:IPR012782" /db_xref="InterPro:IPR029035" /db_xref="InterPro:IPR029061" /db_xref="SubtiList:BG10471" /db_xref="UniProtKB/Swiss-Prot:Q04789" /translation="MTKATKEQKSLVKNRGAELVVDCLVEQGVTHVFGIPGAKIDAVF DALQDKGPEIIVARHEQNAAFMAQAVGRLTGKPGVVLVTSGPGASNLATGLLTANTEG DPVVALAGNVIRADRLKRTHQSLDNAALFQPITKYSVEVQDVKNIPEAVTNAFRIASA GQAGAAFVSFPQDVVNEVTNTKNVRAVAAPKLGPAADDAISAAIAKIQTAKLPVVLVG MKGGRPEAIKAVRKLLKKVQLPFVETYQAAGTLSRDLEDQYFGRIGLFRNQPGDLLLE QADVVLTIGYDPIEYDPKFWNINGDRTIIHLDEIIADIDHAYQPDLELIGDIPSTINH IEHDAVKVEFAEREQKILSDLKQYMHEGEQVPADWKSDRAHPLEIVKELRNAVDDHVT VTCDIGSHAIWMSRYFRSYEPLTLMISNGMQTLGVALPWAIGASLVKPGEKVVSVSGD GGFLFSAMELETAVRLKAPIVHIVWNDSTYDMVAFQQLKKYNRTSAVDFGNIDIVKYA ESFGATGLRVESPDQLADVLRQGMNAEGPVIIDVPVDYSDNINLASDKLPKEFGELMK TKAL*" /label="alsS CDS" gene complement(3333951..3335663) /gene="alsS" /locus_tag="BSU_36010" /old_locus_tag="BSU36010" /label="alsS gene" promotor_-35 3334562..3334571 /Source="Nicolas_upshift_promotors" /id="U2820" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1377 /SigmaFactorBS="acgatttcaagagggtgcgctctgtctgatttccaatCTGCA GGCACctgctcaccttcaTGCATATATTGTTTTAAATCagaaaggattttctgctcac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3334585..3334604 /Source="Nicolas_upshift_promotors" /id="U2820" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1377 /SigmaFactorBS="acgatttcaagagggtgcgctctgtctgatttccaatCTGCA GGCACctgctcaccttcaTGCATATATTGTTTTAAATCagaaaggattttctgctcac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3334585 /Source="Nicolas_upshifts" /id="U2820" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1377 /SigmaFactorBS="acgatttcaagagggtgcgctctgtctgatttccaatCTGCA GGCACctgctcaccttcaTGCATATATTGTTTTAAATCagaaaggattttctgctcac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3335717..3335736) /Source="Nicolas_upshift_promotors" /id="U2821" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.993006993006993" /xcortree=1577 /SigmaFactorBS="tacatattaatcataaggcgaatcgatATTGGaggtcaattt ccaaAGAGTGTATAGTGAAACTTAtcacaagatatttaaaattttacgtttaaaatgc a" /listShort="alsS, alsD, ywrO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3335722) /Source="Nicolas_upshifts" /id="U2821" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.993006993006993" /xcortree=1577 /SigmaFactorBS="tacatattaatcataaggcgaatcgatATTGGaggtcaattt ccaaAGAGTGTATAGTGAAACTTAtcacaagatatttaaaattttacgtttaaaatgc a" /listShort="alsS, alsD, ywrO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3335742..3335749 /Source="Nicolas_upshift_promotors" /id="U2822" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.498501498501498" /psig="0.985014985014985" /xcortree=99 /SigmaFactorBS="gtgataagtttcactatacactctttggaAATTGACCtccaa tatcgattCGCCTTATGATTAATATGTAatacgaattattaacctatggaaaggaatg c" /listShort="alsR, S1385" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(3335751..3335755) /Source="Nicolas_upshift_promotors" /id="U2821" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.993006993006993" /xcortree=1577 /SigmaFactorBS="tacatattaatcataaggcgaatcgatATTGGaggtcaattt ccaaAGAGTGTATAGTGAAACTTAtcacaagatatttaaaattttacgtttaaaatgc a" /listShort="alsS, alsD, ywrO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3335763..3335782 /Source="Nicolas_upshift_promotors" /id="U2822" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.498501498501498" /psig="0.985014985014985" /xcortree=99 /SigmaFactorBS="gtgataagtttcactatacactctttggaAATTGACCtccaa tatcgattCGCCTTATGATTAATATGTAatacgaattattaacctatggaaaggaatg c" /listShort="alsR, S1385" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3335773 /Source="Nicolas_upshifts" /id="U2822" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.498501498501498" /psig="0.985014985014985" /xcortree=99 /SigmaFactorBS="gtgataagtttcactatacactctttggaAATTGACCtccaa tatcgattCGCCTTATGATTAATATGTAatacgaattattaacctatggaaaggaatg c" /listShort="alsR, S1385" /GFF_Attribute="listLong" /label="upshifts" CDS 3335821..3336729 /gene="alsR" /locus_tag="BSU_36020" /old_locus_tag="BSU36020" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10809684, 10972805, 12363365, 15978075, 17183216, 7685336, 22178965, 23576037, 23695583, 23836140" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10809684, 10972805, 12363365, 15978075, 17183216, 7685336, 22178965, 23576037, 23695583, 23836140; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator controlling alsSD, ictEP expression (LysR family)" /protein_id="NP_391483.1" /db_xref="EnsemblGenomes-Gn:BSU36020" /db_xref="EnsemblGenomes-Tr:CAB15619" /db_xref="GOA:Q04778" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10470" /db_xref="UniProtKB/Swiss-Prot:Q04778" /translation="MELRHLQYFIAVAEELHFGKAARRLNMTQPPLSQQIKQLEEEVG VTLLKRTKRFVELTAAGEIFLNHCRMALMQIGQGIELAQRTARGEQGLLVIGFVGSAT YEFLPPIVREYRKKFPSVKIELREISSSRQQEELLKGNIDIGILHPPLQHTALHIETA QSSPCVLALPKQHPLTSKESITIEDLRDEPIITVAKEAWPTLYMDFIQFCEQAGFRPN IVQEATEYQMVIGLVSAGIGMTFVPSSAKKLFNLDVTYRKMDQIQLNAEWVIAYRKDN HNPLIKHFIHISNCQQTRTKESDAGT*" /label="alsR CDS" gene 3335821..3336729 /gene="alsR" /locus_tag="BSU_36020" /old_locus_tag="BSU36020" /label="alsR gene" promotor_-35 3336797..3336805 /Source="Nicolas_upshift_promotors" /id="U2823" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.896103896103896" /psig="0.896103896103896" /xcortree=1419 /SigmaFactorBS="ttttttcttttgggattcttatggaatttttattaatttaat ataatcgcTTAGTACAActttatatcagtaTACGTATACATACAGTACAAatagttgg c" /listShort="S1385, ywrK" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3336807..3336939 /Source="Nicolas_S_feature" /locus_tag="new_3712484_3712616" /HighExp="BT, S8, B36, S7, G/S, S6, Pyr, B60, Etha, Glucon" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.14666000000000001" /TUshortSig="SigK, SigA" /TUshortPSig="0.896, 0.985" /TUlongSig="NA" /TUlongPSig="NA" /label="S1385" upshifts 3336807 /Source="Nicolas_upshifts" /id="U2823" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.896103896103896" /psig="0.896103896103896" /xcortree=1419 /SigmaFactorBS="ttttttcttttgggattcttatggaatttttattaatttaat ataatcgcTTAGTACAActttatatcagtaTACGTATACATACAGTACAAatagttgg c" /listShort="S1385, ywrK" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3336819..3336838 /Source="Nicolas_upshift_promotors" /id="U2823" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.896103896103896" /psig="0.896103896103896" /xcortree=1419 /SigmaFactorBS="ttttttcttttgggattcttatggaatttttattaatttaat ataatcgcTTAGTACAActttatatcagtaTACGTATACATACAGTACAAatagttgg c" /listShort="S1385, ywrK" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3336940..3338268 /gene="ywrK" /locus_tag="BSU_36030" /old_locus_tag="BSU36030" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na+/H+ antiporter" /protein_id="NP_391484.1" /db_xref="EnsemblGenomes-Gn:BSU36030" /db_xref="EnsemblGenomes-Tr:CAB15620" /db_xref="GOA:O05224" /db_xref="InterPro:IPR000802" /db_xref="SubtiList:BG12527" /db_xref="UniProtKB/Swiss-Prot:O05224" /translation="MLAFFVTMIFIFWRPKGLNEAIPATFGALMVLLCGSVSLADLGE IGTKVTGASVTILATMIMAIALESFGFFYWVAAKLLQQSKGSGIKLFWLTNLLCFLMT IFLNNDGSILITTPILLLVLKYLGLKKHQKAPYLLSGVLIATASSAPIGVSNIVNLIS LKIIGMDLYLHTAMMFVPSMMGLIFMTCLLFMFFYKRLPKSLPDIPGHFQSLRHRRYH PLHSPSAPLPERNQTKIMLFVLAFVFLVRMSLFAASYTGISVPLVAVIGSFILLSWRW IYFKTSPRDLLYKSPWHIFIFAFTMYVLIYGLHNIGFTELLVSYFEPVVSGSLAHATF ASGISTSVFSNLFNNHPALMISTFTLTEMTLNPSTTKIIYLANIIGSDIGSLLLPMGT LATLIWMHILKQHDESISWGEYIKTTIIIIPLTVLFTLTCLYFWISWLFL*" /label="ywrK CDS" gene 3336940..3338268 /gene="ywrK" /locus_tag="BSU_36030" /old_locus_tag="BSU36030" /label="ywrK gene" downshifts 3338259 /Source="Nicolas_upshifts" /id="D1861" /incds=0 /nref=16 /ntot=32 /MaxReadThrough="1.63489" /MaxDrop="6.12455" /score="-6.14091334" /energy="-11.9" /TU="NA" /idTUdmin="U2823" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3338325..3339002) /gene="ywrJ" /locus_tag="BSU_36040" /old_locus_tag="BSU36040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 14762006, 22882546" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391485.1" /db_xref="EnsemblGenomes-Gn:BSU36040" /db_xref="EnsemblGenomes-Tr:CAB15621" /db_xref="InterPro:IPR020139" /db_xref="InterPro:IPR020173" /db_xref="SubtiList:BG12526" /db_xref="UniProtKB/Swiss-Prot:O05223" /translation="MKGLNQFLNTDVEVVISGDTRFVGTLIDIGQDIFVIFDGCNYLY IPLLHLHQINKAKIVTSTEKPFLINPEDPMIEAETQAFSYRNTLNKVKGQFIEVYVTG GRSIHGYVTNVLNDYIVFFSPVFKILFISMHHLKWFTPYSTEQTPYTLDNSQLPVVPS KVPLVRNFEEQIKKNIGELVIFDMGEVPEKVGLLKGVSNNIIELINASGEPVIWKLNH LKTMHLP*" /label="ywrJ CDS" gene complement(3338325..3339002) /gene="ywrJ" /locus_tag="BSU_36040" /old_locus_tag="BSU36040" /label="ywrJ gene" downshifts complement(3338335) /Source="Nicolas_upshifts" /id="D1862" /incds=0 /nref=14 /ntot=28 /MaxReadThrough="1.74629" /MaxDrop="5.1172" /score="-4.02447737" /energy="-9.5" /TU="NA" /idTUdmin="U2824" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3339062..3340204) /gene="cotB" /locus_tag="BSU_36050" /old_locus_tag="BSU36050" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:8755863, 10559171, 11737650, 14762006, 19933362, 27185916" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8755863, 10559171, 11737650, 14762006, 19933362, 27185916; Product type s : structure" /codon_start=1 /transl_table=11 /product="spore coat protein (outer)" /protein_id="NP_391486.1" /db_xref="EnsemblGenomes-Gn:BSU36050" /db_xref="EnsemblGenomes-Tr:CAB15622" /db_xref="GOA:P07789" /db_xref="SubtiList:BG10491" /db_xref="UniProtKB/Swiss-Prot:P07789" /translation="MSKRRMKYHSNNEISYYNFLHSMKDKIVTVYRGGPESKKGKLTA VKSDYIALQAEKKIIYYQLEHVKSITEDTNNSTTTIETEEMLDADDFHSLIGHLINQS VQFNQGGPESKKGRLVWLGDDYAALNTNEDGVVYFNIHHIKSISKHEPDLKIEEQTPV GVLEADDLSEVFKSLTHKWVSINRGGPEAIEGILVDNADGHYTIVKNQEVLRIYPFHI KSISLGPKGSYKKEDQKNEQNQEDNNDKDSNSFISSKSYSSSKSSKRSLKSSDDQSSK SGRSSRSKSSSKSSKRSLKSSDYQSSKSGRSSRSKSSSKSSKRSLKSSDYQSSKSSKR SPRSSDYQSSRSPGYSSSIKSSGKQKEDYSYETIVRTIDYHWKRKF*" /label="cotB CDS" gene complement(3339062..3340204) /gene="cotB" /locus_tag="BSU_36050" /old_locus_tag="BSU36050" /label="cotB gene" promotor_-10 complement(3340241..3340260) /Source="Nicolas_upshift_promotors" /id="U2824" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.932067932067932" /psig="0.932067932067932" /xcortree=1302 /SigmaFactorBS="ggaaaaagcgacaattaggctattgaaTTAGTTCAAcaaata aatgtgaCACGTATATATGCAGTATGTttatcatctatgtataagtgactaggaggaa t" /listShort="cotB, ywrJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3340249) /Source="Nicolas_upshifts" /id="U2824" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.932067932067932" /psig="0.932067932067932" /xcortree=1302 /SigmaFactorBS="ggaaaaagcgacaattaggctattgaaTTAGTTCAAcaaata aatgtgaCACGTATATATGCAGTATGTttatcatctatgtataagtgactaggaggaa t" /listShort="cotB, ywrJ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3340251..3340331) /Source="Nicolas_S_feature" /locus_tag="new_3715928_3716008_c" /HighExp="S6, S7, S8, S5, BT, B36, S4, G/S, Pyr, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigK" /TUshortPSig="0.142, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1386" promotor_-35 complement(3340274..3340282) /Source="Nicolas_upshift_promotors" /id="U2824" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.932067932067932" /psig="0.932067932067932" /xcortree=1302 /SigmaFactorBS="ggaaaaagcgacaattaggctattgaaTTAGTTCAAcaaata aatgtgaCACGTATATATGCAGTATGTttatcatctatgtataagtgactaggaggaa t" /listShort="cotB, ywrJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3340332..3341420) /gene="cotH" /locus_tag="BSU_36060" /old_locus_tag="BSU36060" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:14762006, 25115591, 27185916" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14762006, 25115591, 27185916; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein kinase" /protein_id="NP_391487.1" /db_xref="EnsemblGenomes-Gn:BSU36060" /db_xref="EnsemblGenomes-Tr:CAB15623" /db_xref="GOA:Q45535" /db_xref="InterPro:IPR014867" /db_xref="SubtiList:BG11791" /db_xref="UniProtKB/Swiss-Prot:Q45535" /translation="MKNQSNLPLYQLFVHPKDLRELKKDIWDDDPVPAVMKVNQKRLD IDIAYRGSHIRDFKKKSYHISFYQPKTFRGAREIHLNAEYKDPSLMRNKLSLDFFSEL GTLSPKAEFAFVKMNGKNEGVYLELESVDEYYLAKRKLADGAIFYAVDDDANFSLMSD LERETKTSLELGYEKKTGTEEDDFYLQDMIFKINTVPKAQFKSEVTKHVDVDKYLRWL AGIVFTSNYDGFVHNYALYRSGETGLFEVIPWDYDATWGRDIHGERMAADYVRIQGFN TLTARILDESEFRKSYKRLLEKTLQSLFTIEYMEPKIMAMYERIRPFVLMDPYKKNDI ERFDREPDVICEYIKNRSQYLKDHLSIL*" /label="cotH CDS" gene complement(3340332..3341420) /gene="cotH" /locus_tag="BSU_36060" /old_locus_tag="BSU36060" /label="cotH gene" S_feature complement(3341421..3341534) /Source="Nicolas_S_feature" /locus_tag="new_3717098_3717211_c" /HighExp="S6, S8, S7, S5, BT, B36, Pyr, G/S, S4, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigK" /TUshortPSig="0.142, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1387" promotor_-35 3341476..3341485 /Source="Nicolas_upshift_promotors" /id="U2825" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1411 /SigmaFactorBS="tatttttataagatctcagcggaacACTTATACACtttttaa aaccgCGCGTACTATGAGGGTAGTAaggatcttcatccttaacatatttttaaaagga g" /listShort="cotG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3341498..3341517 /Source="Nicolas_upshift_promotors" /id="U2825" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1411 /SigmaFactorBS="tatttttataagatctcagcggaacACTTATACACtttttaa aaccgCGCGTACTATGAGGGTAGTAaggatcttcatccttaacatatttttaaaagga g" /listShort="cotG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3341511 /Source="Nicolas_upshifts" /id="U2825" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1411 /SigmaFactorBS="tatttttataagatctcagcggaacACTTATACACtttttaa aaccgCGCGTACTATGAGGGTAGTAaggatcttcatccttaacatatttttaaaagga g" /listShort="cotG" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3341534) /Source="Nicolas_upshifts" /id="U2826" /multdbtbs="SigK" /comp="M15" /sig="Sig-" /pcomp="0.817182817182817" /psig="0.141858141858142" /xcortree=1262 /SigmaFactorBS="cttcttcgatgtcagaatgggaatagtggCCCAAtttgaaat CCTCCTTTTAAAAATatgttaaggatgaagatccttactaccctcatagtacgcgcgg t" /listShort="S1387, cotH, S1386, cotB, ywrJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3341538..3341552) /Source="Nicolas_upshift_promotors" /id="U2826" /multdbtbs="SigK" /comp="M15" /sig="Sig-" /pcomp="0.817182817182817" /psig="0.141858141858142" /xcortree=1262 /SigmaFactorBS="cttcttcgatgtcagaatgggaatagtggCCCAAtttgaaat CCTCCTTTTAAAAATatgttaaggatgaagatccttactaccctcatagtacgcgcgg t" /listShort="S1387, cotH, S1386, cotB, ywrJ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3341561..3341565) /Source="Nicolas_upshift_promotors" /id="U2826" /multdbtbs="SigK" /comp="M15" /sig="Sig-" /pcomp="0.817182817182817" /psig="0.141858141858142" /xcortree=1262 /SigmaFactorBS="cttcttcgatgtcagaatgggaatagtggCCCAAtttgaaat CCTCCTTTTAAAAATatgttaaggatgaagatccttactaccctcatagtacgcgcgg t" /listShort="S1387, cotH, S1386, cotB, ywrJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3341561..3342148 /gene="cotG" /locus_tag="BSU_36070" /old_locus_tag="BSU36070" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11737650, 14762006, 15621419, 22720735, 25115591, 27185916" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11737650, 14762006, 15621419, 22720735, 25115591, 27185916; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="spore morphogenetic protein" /protein_id="NP_391488.1" /db_xref="EnsemblGenomes-Gn:BSU36070" /db_xref="EnsemblGenomes-Tr:CAB15624" /db_xref="GOA:P39801" /db_xref="SubtiList:BG11017" /db_xref="UniProtKB/Swiss-Prot:P39801" /translation="MGHYSHSDIEEAVKSAKKEGLKDYLYQEPHGKKRSHKKSHRTHK KSRSHKKSYCSHKKSRSHKKSFCSHKKSRSHKKSYCSHKKSRSHKKSYRSHKKSRSYK KSYRSYKKSRSYKKSCRSYKKSRSYKKSYCSHKKKSRSYKKSCRTHKKSYRSHKKYYK KPHHHCDDYKRHDDYDSKKEYWKDGNCWVVKKKYK*" /label="cotG CDS" gene 3341561..3342148 /gene="cotG" /locus_tag="BSU_36070" /old_locus_tag="BSU36070" /label="cotG gene" CDS 3341649..3342128 /locus_tag="BSU_36079" /old_locus_tag="BSU36079" /function="14.1: Surface structures" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="doubtful CDS (putative in frame frameshift)" /protein_id="YP_009514005.1" /translation="MEKNAVIKSRTALTKNLAAIKNHTALTKNLAVTKNHSVLTKNLA ATKNHTALTRNLAATKNRTVLTKNLAAIKNLTVLTKNLVAIKNLAVLTKNLAATKSLT VLTRKNLAAIRSHAAHTKNLIVPIRNTTKNRTTTATTTKDTMIMTAKKNTGKTAIAG* " /label="doubtful CDS (putative in frame frameshift)" gene 3341649..3342128 /locus_tag="BSU_36079" /old_locus_tag="BSU36079" /label="gene" S_feature complement(3342032..3342229) /Source="Nicolas_S_feature" /locus_tag="new_3717709_3717906_c" /HighExp="S5, S6, S4, B60, S3, nit, G/S, SMMPr, S8, ferm" /AntisenseName="cotG" /AntisenseCor="0.60092819988141299" /AntisenseRegPval="-27.1" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1388" downshifts 3342065 /Source="Nicolas_upshifts" /id="D1863" /incds=1 /nref=1 /ntot=54 /MaxReadThrough="7.80801" /MaxDrop="2.7794" /score="17.1895651" /energy="-10.7" /TU="U2825" /idTUdmin="U2825" /TUdmin="-154" /isTUend="FALSE" /label="downshifts" downshifts complement(3342075) /Source="Nicolas_upshifts" /id="D1864" /incds=1 /nref=3 /ntot=23 /MaxReadThrough="4.99409" /MaxDrop="6.67733" /score="-1.37249416" /energy="-5.2" /TU="U2827" /idTUdmin="U2824" /TUdmin="-3740" /isTUend="FALSE" /label="downshifts" downshifts 3342134 /Source="Nicolas_upshifts" /id="D1865" /incds=0 /nref=41 /ntot=80 /MaxReadThrough="4.68169" /MaxDrop="5.35584" /score="17.1895651" /energy="-10.7" /TU="U2825" /idTUdmin="U2825" /TUdmin="-85" /isTUend="FALSE" /label="downshifts" downshifts 3342213 /Source="Nicolas_upshifts" /id="D1866" /incds=0 /nref=4 /ntot=17 /MaxReadThrough="2.30708" /MaxDrop="3.92552" /score="17.1895651" /energy="-10.7" /TU="NA" /idTUdmin="U2825" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3342228..3342247) /Source="Nicolas_upshift_promotors" /id="U2827" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1268 /SigmaFactorBS="accttgattataacgaaatggtttaAAGGAAACCAaatgatg cgggtTGCATATGTTATGTCATGACatatatctaatacagggcaaataaaaaaatagg c" /listShort="S1388, S1387, cotH, S1386, cotB, ywrJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3342234) /Source="Nicolas_upshifts" /id="U2827" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1268 /SigmaFactorBS="accttgattataacgaaatggtttaAAGGAAACCAaatgatg cgggtTGCATATGTTATGTCATGACatatatctaatacagggcaaataaaaaaatagg c" /listShort="S1388, S1387, cotH, S1386, cotB, ywrJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3342256..3342263 /Source="Nicolas_upshift_promotors" /id="U2828" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=1941 /SigmaFactorBS="atatgtcatgacataacatatgcaacccgcatCATTTGGTtt cctttaaaccatTTCGTTATAATCAAGGTATCctaacgataaaggcggttgttgctat g" /listShort="ywrF, S1389, ywrE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(3342260..3342269) /Source="Nicolas_upshift_promotors" /id="U2827" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1268 /SigmaFactorBS="accttgattataacgaaatggtttaAAGGAAACCAaatgatg cgggtTGCATATGTTATGTCATGACatatatctaatacagggcaaataaaaaaatagg c" /listShort="S1388, S1387, cotH, S1386, cotB, ywrJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3342278..3342297 /Source="Nicolas_upshift_promotors" /id="U2828" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=1941 /SigmaFactorBS="atatgtcatgacataacatatgcaacccgcatCATTTGGTtt cctttaaaccatTTCGTTATAATCAAGGTATCctaacgataaaggcggttgttgctat g" /listShort="ywrF, S1389, ywrE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3342284 /Source="Nicolas_upshifts" /id="U2828" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=1941 /SigmaFactorBS="atatgtcatgacataacatatgcaacccgcatCATTTGGTtt cctttaaaccatTTCGTTATAATCAAGGTATCctaacgataaaggcggttgttgctat g" /listShort="ywrF, S1389, ywrE" /GFF_Attribute="listLong" /label="upshifts" CDS 3342322..3342939 /gene="ywrF" /locus_tag="BSU_36080" /old_locus_tag="BSU36080" /EC_number="1.14.13.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative flavin-binding monooxygenase" /protein_id="NP_391489.1" /db_xref="EnsemblGenomes-Gn:BSU36080" /db_xref="EnsemblGenomes-Tr:CAB15625" /db_xref="GOA:O05220" /db_xref="InterPro:IPR002563" /db_xref="InterPro:IPR012349" /db_xref="SubtiList:BG12525" /db_xref="UniProtKB/Swiss-Prot:O05220" /translation="MYIFQADQLSAKDTYKLLSGTVIPRPIAFVTTLSSGGAVNAAPF SFYNVVSSDPPLLSISVNRTEGRQKDTARNAVENGEFVVHVSDEAIIEDINETAASLR PDESELTRTSLHPVESKAVSVPGIKEARVRFECKLERHITFDNDQGITTADLLIGRVV CFHLDEKVYDAEKGYILTDELKPASRLAGNHYAKLGEEFTLIRPS*" /label="ywrF CDS" gene 3342322..3342939 /gene="ywrF" /locus_tag="BSU_36080" /old_locus_tag="BSU36080" /label="ywrF gene" S_feature 3342940..3343040 /Source="Nicolas_S_feature" /locus_tag="new_3718617_3718717" /HighExp="Etha, dia5, Diami, dia15, Lbtran, LBGtran, LPhT, M40t45, M40t90, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1389" downshifts 3342997 /Source="Nicolas_upshifts" /id="D1867" /incds=0 /nref=11 /ntot=56 /MaxReadThrough="4.52989" /MaxDrop="4.48979" /score="-1.9002322" /energy="-14.9" /TU="U2828" /idTUdmin="U2828" /TUdmin="-454" /isTUend="FALSE" /label="downshifts" promotor_-35 3343066..3343075 /Source="Nicolas_upshift_promotors" /id="U2829" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1701 /SigmaFactorBS="aaaaagaacacccagagcaagctcggggtgttcttttaTGAA ACGTTTttcctttttctTCGTATAAAGGTAGATtaggaggaattggaatgacaaactt t" /listShort="ywrE, S1390, ywrC, ywrB, ywrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3343087..3343102 /Source="Nicolas_upshift_promotors" /id="U2829" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1701 /SigmaFactorBS="aaaaagaacacccagagcaagctcggggtgttcttttaTGAA ACGTTTttcctttttctTCGTATAAAGGTAGATtaggaggaattggaatgacaaactt t" /listShort="ywrE, S1390, ywrC, ywrB, ywrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3343088 /Source="Nicolas_upshifts" /id="U2829" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1701 /SigmaFactorBS="aaaaagaacacccagagcaagctcggggtgttcttttaTGAA ACGTTTttcctttttctTCGTATAAAGGTAGATtaggaggaattggaatgacaaactt t" /listShort="ywrE, S1390, ywrC, ywrB, ywrA" /GFF_Attribute="listLong" /label="upshifts" CDS 3343117..3343452 /gene="ywrE" /locus_tag="BSU_36090" /old_locus_tag="BSU36090" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391490.1" /db_xref="EnsemblGenomes-Gn:BSU36090" /db_xref="EnsemblGenomes-Tr:CAB15626" /db_xref="GOA:O05219" /db_xref="InterPro:IPR025441" /db_xref="SubtiList:BG12524" /db_xref="UniProtKB/Swiss-Prot:O05219" /translation="MTNFWILMLIAITISLASQFFIKKKYGIDKSGWRYKHVSNTHKW IEITLLILFVFSLSFFPVEYLLLLFFIVIDSIRIFMEWHYRPEDKQYMYHIVEVSLMF MLLIYVCTL*" /label="ywrE CDS" gene 3343117..3343452 /gene="ywrE" /locus_tag="BSU_36090" /old_locus_tag="BSU36090" /label="ywrE gene" promotor_-10 complement(3343408..3343426) /Source="Nicolas_upshift_promotors" /id="U2830" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1203 /SigmaFactorBS="ggagcggctgtggggatttaaataactatagGGTACAaacat aaatcaaaaGCATAAACATAAGGGAGACctctacaatgtggtacatatactgtttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3343417) /Source="Nicolas_upshifts" /id="U2830" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1203 /SigmaFactorBS="ggagcggctgtggggatttaaataactatagGGTACAaacat aaatcaaaaGCATAAACATAAGGGAGACctctacaatgtggtacatatactgtttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3343441..3343446) /Source="Nicolas_upshift_promotors" /id="U2830" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1203 /SigmaFactorBS="ggagcggctgtggggatttaaataactatagGGTACAaacat aaatcaaaaGCATAAACATAAGGGAGACctctacaatgtggtacatatactgtttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3343451 /Source="Nicolas_upshifts" /id="D1868" /incds=0 /nref=5 /ntot=153 /MaxReadThrough="5.64855" /MaxDrop="3.64569" /score="-1.9002322" /energy="-14.9" /TU="U2829" /idTUdmin="U2828" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3343457..3345034) /gene="hpxW" /locus_tag="BSU_36100" /old_locus_tag="BSU36100" /EC_number="3.5.1.126" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12823818, 14762019, 19935659, 27303801, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oxamate amidohydrolase" /protein_id="NP_391491.1" /db_xref="EnsemblGenomes-Gn:BSU36100" /db_xref="EnsemblGenomes-Tr:CAB15627" /db_xref="GOA:O05218" /db_xref="InterPro:IPR000101" /db_xref="InterPro:IPR029055" /db_xref="SubtiList:BG12523" /db_xref="UniProtKB/Swiss-Prot:O05218" /translation="MNKSVIGTKQMVVSPHYLASQAGNRILDKGGNAFDAAVAVSACL AVVYPHMTGLGGDSFWLTFHQETKAVKVYNGSGRSGKNVTRDVYKGKSAIPLRGIDSA ITVPGMVDSWDAVLKEYGRLSLADVLEPARDYAQNGFPVSADQCRHTEKNIELLASTP YTADIFTRRGKAPVPGERFVQKELADSLNLIAEKGRSAFYEGDLAQRIVSHLQNNGSY MTIDDFKAHRGEWAAPVSSDYRGYSVYQAPPNSQGFTGLLTLNILENYDFTQIEHGSF EYYHVLVEALKKSFLDRDAVLTDPAFADIPLERLLDKRYAKQLAEEIGYLAIPAESRP VGSDTAYAAVIDADGNAVSFIQSLYFEFGSAVTAGDTGILLQNRGSFFSLDENHVNTL EPRKRTFHTLMPAMVCKGGKPKILYGTQGGEGQPQTQTAIITRMLDYGMHPQQAISEP RWVWGRTWGEEYEGLRVEGRFTDKTIQKLKDSGHLVEVVGDYDPLMGQAAAIKVDEEG FLQGGADPRGDGAAVGI*" /label="hpxW CDS" gene complement(3343457..3345034) /gene="hpxW" /locus_tag="BSU_36100" /old_locus_tag="BSU36100" /label="hpxW gene" S_feature 3343496..3345207 /Source="Nicolas_S_feature" /locus_tag="new_3719173_3720884" /HighExp="T1.0H, T0.30H, T1.30H, T2.0H, T2.30H, T3.30H, T3.0H, T-0.40H, T0.0H, Salt" /AntisenseName="ywrD" /AntisenseCor="0.153519829066777" /AntisenseRegPval="-1.9" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1390" promotor_-35 3345185..3345192 /Source="Nicolas_upshift_promotors" /id="U2831" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=2447 /SigmaFactorBS="tttcgcattcatttcgaaaacaaatgaaaaattattATTTCT ATacgtaactttTATGATAAAATGATTGCTAAaaggctacgaaagcaggtggagcaat t" /listShort="ywrC, ywrB, ywrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3345203..3345222 /Source="Nicolas_upshift_promotors" /id="U2831" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=2447 /SigmaFactorBS="tttcgcattcatttcgaaaacaaatgaaaaattattATTTCT ATacgtaactttTATGATAAAATGATTGCTAAaaggctacgaaagcaggtggagcaat t" /listShort="ywrC, ywrB, ywrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3345209 /Source="Nicolas_upshifts" /id="U2831" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=2447 /SigmaFactorBS="tttcgcattcatttcgaaaacaaatgaaaaattattATTTCT ATacgtaactttTATGATAAAATGATTGCTAAaaggctacgaaagcaggtggagcaat t" /listShort="ywrC, ywrB, ywrA" /GFF_Attribute="listLong" /label="upshifts" CDS 3345248..3345724 /gene="chrS" /locus_tag="BSU_36110" /old_locus_tag="BSU36110" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:23989926" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23989926; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional negative regulator of chromate transport (Lrp/AsnC family)" /protein_id="NP_391492.1" /db_xref="EnsemblGenomes-Gn:BSU36110" /db_xref="EnsemblGenomes-Tr:CAB15628" /db_xref="GOA:O05217" /db_xref="InterPro:IPR000485" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR019887" /db_xref="InterPro:IPR019888" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12522" /db_xref="UniProtKB/Swiss-Prot:O05217" /translation="MSHEYQIPNLVLDETDKQILTILHEEGRISYTDLGKRVDLSRVA VQARINQLIEAGVIEKFTAVINPAKIGIHVSVFFNVEVEPQFLEEVALKLEEEPAVTS LYHMTGPSKLHMHGIFTNDQEMEEFLTKRLYPLRGVVSVDCQMLIKRYKSRMGMKL*" /label="chrS CDS" gene 3345248..3345724 /gene="chrS" /locus_tag="BSU_36110" /old_locus_tag="BSU36110" /label="chrS gene" CDS 3345738..3346331 /gene="chrB" /locus_tag="BSU_36120" /old_locus_tag="BSU36120" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 23989926" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 23989926; Product type t: transporter" /codon_start=1 /transl_table=11 /product="chromate transporter subunit N" /protein_id="NP_391493.1" /db_xref="EnsemblGenomes-Gn:BSU36120" /db_xref="EnsemblGenomes-Tr:CAB15629" /db_xref="GOA:O05216" /db_xref="InterPro:IPR003370" /db_xref="SubtiList:BG12521" /db_xref="UniProtKB/Swiss-Prot:O05216" /translation="MKNHPYRDMTAAMVRTGILGFGGGPSVIPLIRHEAVNKYKWIDD DEFGEILAIANALPGPIATKMAAYLGFKLKGTLGAIVAILAHILPTCLAMVGLFAAVN VLSHSAIVAGMIGAVTPVIAVMLGIMAYEFGQKALKGFGWVTGILFFIIAFIGLQTLQ INPGLVIIIFLAYGAFHFKLKDKITNKHSKDKGMSAS*" /label="chrB CDS" gene 3345738..3346331 /gene="chrB" /locus_tag="BSU_36120" /old_locus_tag="BSU36120" /label="chrB gene" CDS 3346328..3346864 /gene="chrA" /locus_tag="BSU_36130" /old_locus_tag="BSU36130" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 23989926" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 23989926; Product type t: transporter" /codon_start=1 /transl_table=11 /product="chromate transporter subunit C" /protein_id="NP_391494.1" /db_xref="EnsemblGenomes-Gn:BSU36130" /db_xref="EnsemblGenomes-Tr:CAB15630" /db_xref="GOA:O05215" /db_xref="InterPro:IPR003370" /db_xref="SubtiList:BG12520" /db_xref="UniProtKB/Swiss-Prot:O05215" /translation="MISIYLFMAFFIANLLGYGGGPASIPLMFEEVVNRYSWLSNDQF SNMLALANALPGPIATKIAAYVGYSAGGWPGFLIALIATVVPSALALIVLLRIIQRFR QSPVIKGMTLSVQPVIAVMMLILTWQIGADGIKAIGWVQSIVITGISLLAMTKFKMHP AFLIIAAFLYGGLVIPYL*" /label="chrA CDS" gene 3346328..3346864 /gene="chrA" /locus_tag="BSU_36130" /old_locus_tag="BSU36130" /label="chrA gene" downshifts 3346845 /Source="Nicolas_upshifts" /id="D1869" /incds=0 /nref=4 /ntot=90 /MaxReadThrough="0.0513700000000004" /MaxDrop="3.46649" /score="29.5508265" /energy="-8.6" /TU="NA" /idTUdmin="U2829" /TUdmin=28 /isTUend="FALSE" /label="downshifts" CDS complement(3346891..3347112) /gene="ywqO" /locus_tag="BSU_36140" /old_locus_tag="BSU36140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391495.1" /db_xref="EnsemblGenomes-Gn:BSU36140" /db_xref="EnsemblGenomes-Tr:CAB15631" /db_xref="SubtiList:BG12519" /db_xref="UniProtKB/Swiss-Prot:P96727" /translation="MKFLLSVIAGLLILALYLFWKVQPPVWIQVETNSSQLKQSVRMA GTTLQVKHMIKSDAGEETAVISNGISGLK*" /label="ywqO CDS" gene complement(3346891..3347112) /gene="ywqO" /locus_tag="BSU_36140" /old_locus_tag="BSU36140" /label="ywqO gene" upshifts 3347059 /Source="Nicolas_upshifts" /id="U2832" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.297702297702298" /psig="0.447552447552448" /xcortree=1475 /SigmaFactorBS="cttcaactgggacgaattggtttcaacttgtatccaaacagg aggctggaccttccaaaataaatagAGtgcaagaatcagcaagccagcaatgaccgac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 3347066..3347067 /Source="Nicolas_upshift_promotors" /id="U2832" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.297702297702298" /psig="0.447552447552448" /xcortree=1475 /SigmaFactorBS="cttcaactgggacgaattggtttcaacttgtatccaaacagg aggctggaccttccaaaataaatagAGtgcaagaatcagcaagccagcaatgaccgac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(3347109..3347654) /gene="ywqN" /locus_tag="BSU_36150" /old_locus_tag="BSU36150" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391496.1" /db_xref="EnsemblGenomes-Gn:BSU36150" /db_xref="EnsemblGenomes-Tr:CAB15632" /db_xref="GOA:P96726" /db_xref="InterPro:IPR005025" /db_xref="InterPro:IPR029039" /db_xref="PDB:1RLI" /db_xref="SubtiList:BG12518" /db_xref="UniProtKB/Swiss-Prot:P96726" /translation="MKIAVINGGTRSGGNTDVLAEKAVQGFDAEHIYLQKYPIQPIED LRHAQGGFRPVQDDYDSIIERILQCHILIFATPIYWFGMSGTLKLFIDRWSQTLRDPR FPDFKQQMSVKQAYVIAVGGDNPKIKGLPLIQQFEHIFHFMGMSFKGYVLGEGNRPGD ILRDHQALSAASRLLKRSDAI*" /label="ywqN CDS" gene complement(3347109..3347654) /gene="ywqN" /locus_tag="BSU_36150" /old_locus_tag="BSU36150" /label="ywqN gene" promotor_-35 3347671..3347678 /Source="Nicolas_upshift_promotors" /id="U2833" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig="0.996003996003996" /xcortree=1866 /SigmaFactorBS="aataaccgcaattttcatgatgcatctgctccttTGTTTACG aatgattttcttcaTCATATAATGGATTCATCAAtcaatacagatgattatttcgatt a" /listShort="ywqM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3347693..3347712 /Source="Nicolas_upshift_promotors" /id="U2833" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig="0.996003996003996" /xcortree=1866 /SigmaFactorBS="aataaccgcaattttcatgatgcatctgctccttTGTTTACG aatgattttcttcaTCATATAATGGATTCATCAAtcaatacagatgattatttcgatt a" /listShort="ywqM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3347697 /Source="Nicolas_upshifts" /id="U2833" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig="0.996003996003996" /xcortree=1866 /SigmaFactorBS="aataaccgcaattttcatgatgcatctgctccttTGTTTACG aatgattttcttcaTCATATAATGGATTCATCAAtcaatacagatgattatttcgatt a" /listShort="ywqM" /GFF_Attribute="listLong" /label="upshifts" CDS 3347777..3348658 /gene="ywqM" /locus_tag="BSU_36160" /old_locus_tag="BSU36160" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (LysR family)" /protein_id="NP_391497.1" /db_xref="EnsemblGenomes-Gn:BSU36160" /db_xref="EnsemblGenomes-Tr:CAB15633" /db_xref="GOA:P96725" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12517" /db_xref="UniProtKB/Swiss-Prot:P96725" /translation="MELKQLITFITAAEHVNFTLTAKMLNYAQSSVTSQIKSLEEEIG TPLFERLGKRLILTEAGKTFKSYAQKIIALTEEAKMATNQVRETTGTLKIGATESQCT YRLPPIIKEFKQAFPQVKLIFKPYISNEQAKEQLLQGQLDITFILDVNRMEDALHVES LIQDEIKMVAANDHPFPADLPVTLKDLQNETLLLTEDGCSYRTLFENNLHDSGIYPNK LEFVSIEAIKQCVMAGLGIGILPEMTVKDDIAAGRMKELNWQSDCPVFTQLAWHKDKW MSAPLKAFIDLTRKTFK*" /label="ywqM CDS" gene 3347777..3348658 /gene="ywqM" /locus_tag="BSU_36160" /old_locus_tag="BSU36160" /label="ywqM gene" CDS complement(3348743..3349459) /gene="nfi" /locus_tag="BSU_36170" /old_locus_tag="BSU36170" /EC_number="3.1.21.7" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1692969, 22056936, 27530626" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1692969, 22056936, 27530626; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endonuclease V" /protein_id="NP_391498.2" /db_xref="EnsemblGenomes-Gn:BSU36170" /db_xref="EnsemblGenomes-Tr:CAB15634" /db_xref="GOA:P96724" /db_xref="InterPro:IPR007581" /db_xref="PDB:3GA2" /db_xref="SubtiList:BG12516" /db_xref="UniProtKB/Swiss-Prot:P96724" /translation="MKVFDVHKFDMKKEQDFLQVQFNLKNRINLSPTIHPDSINTCAG VDLAYWEQDGEPYGVCCIIVIDADTKEVIEKVHSMGRISVPYVSGFLAFRELPLIIEA AKKLETEPDVFLFDGNGYLHYNHMGVATHAAFFLGKPTIGIAKTYLKIKGCDFVTPEI EVGAYTDIIIDGEVYGRALRTRRDVKPIFLSCGNYIDLDSSYQITMSLINQESRLPIP VRLADLETHVLRTFYQKNHV*" /label="nfi CDS" gene complement(3348743..3349459) /gene="nfi" /locus_tag="BSU_36170" /old_locus_tag="BSU36170" /label="nfi gene" downshifts complement(3348763) /Source="Nicolas_upshifts" /id="D1870" /incds=0 /nref=44 /ntot=216 /MaxReadThrough="1.91774" /MaxDrop="3.62442" /score="12.1019223" /energy="-7.4" /TU="NA" /idTUdmin="U2834" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3349469..3349933) /gene="rttO" /locus_tag="BSU_36180" /old_locus_tag="BSU36180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22200572; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ribonuclease antitoxin" /protein_id="NP_391499.1" /db_xref="EnsemblGenomes-Gn:BSU36180" /db_xref="EnsemblGenomes-Tr:CAB15635" /db_xref="InterPro:IPR011652" /db_xref="SubtiList:BG12515" /db_xref="UniProtKB/Swiss-Prot:P96723" /translation="MENEYDMKSIKEKGVDFEDLWFSSVSDEILDNPEDENGQPFTGL AYELYPNGQIIYFTKYKNGLAHGLTCEFYENGNKKSEKEYRYGQLHGISIIWFENGRK KSEQQYEHSILISEKNWDEEGNLLNKYEIDTDSPHFEILESRRETHINLGRE*" /label="rttO CDS" gene complement(3349469..3349933) /gene="rttO" /locus_tag="BSU_36180" /old_locus_tag="BSU36180" /label="rttO gene" CDS complement(3349923..3351731) /gene="rttN" /locus_tag="BSU_36190" /old_locus_tag="BSU36190" /EC_number="3.1.-.-" /function="15.8: Toxin production and resistance" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22200572; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ribonuclease toxin" /protein_id="NP_391500.1" /db_xref="EnsemblGenomes-Gn:BSU36190" /db_xref="EnsemblGenomes-Tr:CAB15636" /db_xref="GOA:P96722" /db_xref="InterPro:IPR006829" /db_xref="InterPro:IPR025968" /db_xref="InterPro:IPR027797" /db_xref="SubtiList:BG12514" /db_xref="UniProtKB/Swiss-Prot:P96722" /translation="MSKVFESKSLIEEAKSRKKQYETLEEQLNTLKKAFQGVADLGDN FKGNGADNIKDFFQGQAEIVDSWLTLVSAQIAFLNGISGDIKDQELNDSYVETSFLDH ELPNGDLKASEIVSAHKEEIDSILSGISDIIDLDMYTLDDYADKMGDAQKIRRDTITA VDKLDESLTTEYQNLESLDNAVLTKYSVLMQATSNGKSASPMYYDKKAFHSNEVYKSV IEVENQGTTYIDAKTQQAEARRLQEKAEEEANKPWYEKTWDGVCNFTGEVTGYYDYKR ATEGVDPVTGEKLSTAERVTAGAMAAAGFIPVVGWAGRAFKGGKAIYKTGKAAIAAEH ALDAYKTGKSLDILKMTEMGAYGLVASNGFSEAVTGRDMFGNKVSEEKRKQGALEAIT IIGGAGLAHYFDRLYQKNAPYVNKVSNESLISNIAKTTEEKQTRLQYLRNKHGVLSKE DLHHRINLRAEVLNELSRIKSSGLTKKQRGPAVAGVLDKKTGNYYFGINNIDGKPPKV LHPLIHDRIVNMPTELKEGYIKTSGAGSHAEVNALNEALLQRPDADLKDLMVYVVSAR KINKKMPEGVPMPRCPHCEYITQNTNYIPEALKYGK*" /label="rttN CDS" gene complement(3349923..3351731) /gene="rttN" /locus_tag="BSU_36190" /old_locus_tag="BSU36190" /label="rttN gene" CDS complement(3351750..3352010) /gene="ywqI" /locus_tag="BSU_36200" /old_locus_tag="BSU36200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391501.1" /db_xref="EnsemblGenomes-Gn:BSU36200" /db_xref="EnsemblGenomes-Tr:CAB15637" /db_xref="InterPro:IPR020299" /db_xref="SubtiList:BG12513" /db_xref="UniProtKB/Swiss-Prot:P96721" /translation="MSEIKLKYDTVIKTLDSVKDALADVSIGAAGSNGKNSLDYTKKY HEREENIKTMLGDYKKAVQKNIEDTKDNVDSLKEQDEAIAVK*" /label="ywqI CDS" gene complement(3351750..3352010) /gene="ywqI" /locus_tag="BSU_36200" /old_locus_tag="BSU36200" /label="ywqI gene" CDS complement(3352020..3352442) /gene="ywqH" /locus_tag="BSU_36210" /old_locus_tag="BSU36210" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15101989" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391502.1" /db_xref="EnsemblGenomes-Gn:BSU36210" /db_xref="EnsemblGenomes-Tr:CAB15638" /db_xref="InterPro:IPR020326" /db_xref="InterPro:IPR031681" /db_xref="SubtiList:BG12512" /db_xref="UniProtKB/Swiss-Prot:P96720" /translation="MGYESMLADIKSSLNGKISDVEDKIEKLKKAKKDIDTLQEEAIT EIKEIVKPELGKHWTGTKADDFDKGREEAKSEASKIVNDKYNEYMASINGKIFDLEWD KAKYASELFIANGAADLLKKGEEFAEEVGNTISKLKWW*" /label="ywqH CDS" gene complement(3352020..3352442) /gene="ywqH" /locus_tag="BSU_36210" /old_locus_tag="BSU36210" /label="ywqH gene" S_feature complement(3352443..3352525) /Source="Nicolas_S_feature" /locus_tag="new_3728120_3728202_c" /HighExp="T2.30H, T4.0H, T5.0H, T3.0H, T3.30H, T1.30H, T2.0H, S4, T-0.40H, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1391" promotor_-10 complement(3352517..3352536) /Source="Nicolas_upshift_promotors" /id="U2834" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.486513486513487" /psig="0.996003996003996" /xcortree=2973 /SigmaFactorBS="gttatatgcctaaattaagccatttacccTATTTAAGccgcc ttctggcTATTTTAAAATATAATATATggaaataaagtatggaaaagtctatcttcat c" /listShort="S1391, ywqH, ywqI, ywqJ, ywqK, ywqL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3352525) /Source="Nicolas_upshifts" /id="U2834" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.486513486513487" /psig="0.996003996003996" /xcortree=2973 /SigmaFactorBS="gttatatgcctaaattaagccatttacccTATTTAAGccgcc ttctggcTATTTTAAAATATAATATATggaaataaagtatggaaaagtctatcttcat c" /listShort="S1391, ywqH, ywqI, ywqJ, ywqK, ywqL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3352549..3352556) /Source="Nicolas_upshift_promotors" /id="U2834" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.486513486513487" /psig="0.996003996003996" /xcortree=2973 /SigmaFactorBS="gttatatgcctaaattaagccatttacccTATTTAAGccgcc ttctggcTATTTTAAAATATAATATATggaaataaagtatggaaaagtctatcttcat c" /listShort="S1391, ywqH, ywqI, ywqJ, ywqK, ywqL" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3352659..3352784) /locus_tag="BSU_36215" /old_locus_tag="BSU36215" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514006.1" /translation="MTKSDMADQMKNINMNNKLSAERGRSTTSASFKCLYNYDIR*" /label="hypothetical protein CDS" gene complement(3352659..3352784) /locus_tag="BSU_36215" /old_locus_tag="BSU36215" /label="gene" S_feature complement(3352702..3352833) /Source="Nicolas_S_feature" /locus_tag="new_3728379_3728510_c" /HighExp="HiOs, BI, M9-tran, T-2.40H, MG 150, Sw, M9-exp, S1, T-3.40H, T-4.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.19133600000000001" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1392" downshifts complement(3352745) /Source="Nicolas_upshifts" /id="D1871" /incds=0 /nref=29 /ntot=208 /MaxReadThrough="3.03928" /MaxDrop="3.47153" /score="16.9931891" /energy="-8.4" /TU="NA" /idTUdmin="U2835" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3352834..3353619) /gene="ywqG" /locus_tag="BSU_36220" /old_locus_tag="BSU36220" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391503.1" /db_xref="EnsemblGenomes-Gn:BSU36220" /db_xref="EnsemblGenomes-Tr:CAB15639" /db_xref="InterPro:IPR015315" /db_xref="InterPro:IPR035948" /db_xref="PDB:1PV5" /db_xref="SubtiList:BG12511" /db_xref="UniProtKB/Swiss-Prot:P96719" /translation="MNHLPEKMRPYRDLLEKSAKEYVKLNVRKGKTGRYDSKIAGDPY FPKHETYPTDENGQPMKLLAQINFSHIPQLDGYPSSGILQFYISVHDDVYGLNFDDRC EQKNFRVIYFENIVENDDELVSDFSFIGTGECDFPILSEAAVEPVKSSEWVLPTDFQF EQYTGMETMEFFGQFGEDEEDIYNELAENGFGHKIGGYASFTQHDPREYAYKEHTIML LQIDSDDDIDSMWGDVGIANFFITPEDLRKKDFSNVLYNWDCS*" /label="ywqG CDS" gene complement(3352834..3353619) /gene="ywqG" /locus_tag="BSU_36220" /old_locus_tag="BSU36220" /label="ywqG gene" S_feature complement(3353620..3353735) /Source="Nicolas_S_feature" /locus_tag="new_3729297_3729412_c" /HighExp="HiOs, T-1.40H, T-2.40H, T-3.40H, M9-tran, MG 150, SMM, GM 150, T0.0H, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1393" promotor_-10 complement(3353728..3353747) /Source="Nicolas_upshift_promotors" /id="U2835" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig="0.998001998001998" /xcortree=3015 /SigmaFactorBS="tggttgcgcaccagtctttttttcatcTATTGCGGggtgctg aatacaTTTGCTACTATTTAACTATTgtttggaaaattatgcagaagtagggcttctt t" /listShort="S1393, ywqG, S1392" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3353735) /Source="Nicolas_upshifts" /id="U2835" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig="0.998001998001998" /xcortree=3015 /SigmaFactorBS="tggttgcgcaccagtctttttttcatcTATTGCGGggtgctg aatacaTTTGCTACTATTTAACTATTgtttggaaaattatgcagaagtagggcttctt t" /listShort="S1393, ywqG, S1392" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3353761..3353768) /Source="Nicolas_upshift_promotors" /id="U2835" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig="0.998001998001998" /xcortree=3015 /SigmaFactorBS="tggttgcgcaccagtctttttttcatcTATTGCGGggtgctg aatacaTTTGCTACTATTTAACTATTgtttggaaaattatgcagaagtagggcttctt t" /listShort="S1393, ywqG, S1392" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3353811..3355133) /gene="uglF" /locus_tag="BSU_36230" /old_locus_tag="BSU36230" /EC_number="1.1.1.22" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12970183, 15741737, 15866923, 16415592" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12970183, 15741737, 15866923, 16415592; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-glucose dehydrogenase" /protein_id="NP_391504.1" /db_xref="EnsemblGenomes-Gn:BSU36230" /db_xref="EnsemblGenomes-Tr:CAB15640" /db_xref="GOA:P96718" /db_xref="InterPro:IPR001732" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR014026" /db_xref="InterPro:IPR014027" /db_xref="InterPro:IPR017476" /db_xref="InterPro:IPR021157" /db_xref="InterPro:IPR028357" /db_xref="InterPro:IPR036220" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12510" /db_xref="UniProtKB/Swiss-Prot:P96718" /translation="MNITVIGTGYVGLVTGVSLSEIGHHVTCIDIDAHKIDEMRKGIS PIFEPGLEELMRKNTADGRLNFETSYEKGLAQADIIFIAVGTPQKSDGHANLEQITDA AKRIAKHVKRDTVVVTKSTVPVGTNDLINGLITEHLAEPVSISVASNPEFLREGSAIY DTFHGDRIVIGTADEKTANTLEELFRPFQIPIYQTDIRSAEMIKYASNAFLATKISFI NEISNICEKVGADIEAVAYGMGQDKRIGSQFLKAGIGYGGSCFPKDTNALVQIAGNVE HDFELLKSVIKVNNNQQAMLVDKALNRLGGVTGKTIALLGLSFKPNTDDMREAPSIVI ADRLAALDARIRAYDPIAVSHAKHVLPQAVEYKETIEEAVKGSDAVMILTDWADIKQF PLAAYQDLMETPLIFDGRNCYTLDEALAAGVEYYSVGRKAVVPSGAIQ*" /label="uglF CDS" gene complement(3353811..3355133) /gene="uglF" /locus_tag="BSU_36230" /old_locus_tag="BSU36230" /label="uglF gene" downshifts complement(3353823) /Source="Nicolas_upshifts" /id="D1872" /incds=0 /nref=137 /ntot=221 /MaxReadThrough="3.29767" /MaxDrop="6.20721" /score="16.9931891" /energy="-8.4" /TU="NA" /idTUdmin="U2836" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(3355167) /Source="Nicolas_upshifts" /id="U2836" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1018 /SigmaFactorBS="ggctatgcgggagatcattCGCATTcatgataggatgttcTC ATACGATATTACGGAAGctgcaaagcagcaatttaactgttggagggaaacaatgaat a" /listShort="ywqF" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3355169..3355294) /Source="Nicolas_S_feature" /locus_tag="new_3730846_3730971_c" /HighExp="dia15, H2O2, Diami, dia5, LBGstat, Paraq, LBGexp, G180, G150, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.13453899999999999" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1394" promotor_-10 complement(3355169..3355187) /Source="Nicolas_upshift_promotors" /id="U2836" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1018 /SigmaFactorBS="ggctatgcgggagatcattCGCATTcatgataggatgttcTC ATACGATATTACGGAAGctgcaaagcagcaatttaactgttggagggaaacaatgaat a" /listShort="ywqF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3355203..3355208) /Source="Nicolas_upshift_promotors" /id="U2836" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1018 /SigmaFactorBS="ggctatgcgggagatcattCGCATTcatgataggatgttcTC ATACGATATTACGGAAGctgcaaagcagcaatttaactgttggagggaaacaatgaat a" /listShort="ywqF" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(3355274..3355293) /Source="Nicolas_upshift_promotors" /id="U2837" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.817182817182817" /psig="0.993006993006993" /xcortree=1828 /SigmaFactorBS="agaagaaaattgtttggttttttttaacagccgattctcatt tcaccactttctttttgagAGCGATATAATAGTGTATTGtatggttgaatcacatttc a" /listShort="S1394, ywqF" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3355294) /Source="Nicolas_upshifts" /id="U2837" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.817182817182817" /psig="0.993006993006993" /xcortree=1828 /SigmaFactorBS="agaagaaaattgtttggttttttttaacagccgattctcatt tcaccactttctttttgagAGCGATATAATAGTGTATTGtatggttgaatcacatttc a" /listShort="S1394, ywqF" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3355328..3356092) /gene="ptpZ" /locus_tag="BSU_36240" /old_locus_tag="BSU36240" /EC_number="3.1.3.48" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15866923, 16415592, 16549871, 21605684, 27148221" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15866923, 16415592, 16549871, 21605684, 27148221; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein tyrosine-phosphatase" /protein_id="NP_391505.1" /db_xref="EnsemblGenomes-Gn:BSU36240" /db_xref="EnsemblGenomes-Tr:CAB15641" /db_xref="GOA:P96717" /db_xref="InterPro:IPR016195" /db_xref="InterPro:IPR016667" /db_xref="PDB:3QY6" /db_xref="PDB:3QY7" /db_xref="SubtiList:BG12509" /db_xref="UniProtKB/Swiss-Prot:P96717" /translation="MIDIHCHILPAMDDGAGDSADSIEMARAAVRQGIRTIIATPHHN NGVYKNEPAAVREAADQLNKRLIKEDIPLHVLPGQEIRIYGEVEQDLAKRQLLSLNDT KYILIEFPFDHVPRYAEQLFYDLQLKGYIPVIAHPERNREIRENPSLLYHLVEKGAAS QITSGSLAGIFGKQLKAFSLRLVEANLIHFVASDAHNVKTRNFHTQEALYVLEKEFGS ELPYMLTENAELLLRNQTIFRQPPQPVKRRKLFGFF*" /label="ptpZ CDS" gene complement(3355328..3356092) /gene="ptpZ" /locus_tag="BSU_36240" /old_locus_tag="BSU36240" /label="ptpZ gene" downshifts complement(3356111) /Source="Nicolas_upshifts" /id="D1873" /incds=0 /nref=4 /ntot=152 /MaxReadThrough="3.17433" /MaxDrop="3.31415" /score="15.8630799" /energy="-9.3" /TU="U2838" /idTUdmin="U2838" /TUdmin="-330" /isTUend="FALSE" /label="downshifts" CDS complement(3356145..3356858) /gene="ptkA" /locus_tag="BSU_36250" /old_locus_tag="BSU36250" /EC_number="2.7.10.2" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12970183, 15741737, 16415592, 16549871, 17367396, 20497499, 20815827, 23939619, 24493247, 26283769, 27148221" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12970183, 15741737, 16415592, 16549871, 17367396, 20497499, 20815827, 23939619, 24493247, 26283769, 27148221; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="maintenance protein tyrosine kinase involved in biofilm formation" /protein_id="NP_391506.1" /db_xref="EnsemblGenomes-Gn:BSU36250" /db_xref="EnsemblGenomes-Tr:CAB15642" /db_xref="GOA:P96716" /db_xref="InterPro:IPR005702" /db_xref="InterPro:IPR025669" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12508" /db_xref="UniProtKB/Swiss-Prot:P96716" /translation="MALRKNRGSRMQRNVIAMTEPKSLNSEQYRTIRTNIEFASVDRQ MKSVMITSACPGEGKSTTAANLAVVFAQQGKKVLLIDADLRKPTVHTAFFLENTVGLT SVLLKKSSMEQAVQASNEKHLDVLTSGPIPPNPAELLSSKWMKELAYEACAAYDMVIF DTPPILAVADAQILGNVADGSVLVISSGKTEKEQAAKAKEALATCKSKLLGAIMNGKK LSKHSEYGYYGTKDNFMQK*" /label="ptkA CDS" gene complement(3356145..3356858) /gene="ptkA" /locus_tag="BSU_36250" /old_locus_tag="BSU36250" /label="ptkA gene" downshifts complement(3356162) /Source="Nicolas_upshifts" /id="D1874" /incds=0 /nref=10 /ntot=157 /MaxReadThrough="4.4352" /MaxDrop="4.08842" /score="15.8630799" /energy="-9.3" /TU="U2838" /idTUdmin="U2838" /TUdmin="-381" /isTUend="FALSE" /label="downshifts" CDS complement(3356848..3357594) /gene="tkmA" /locus_tag="BSU_36260" /old_locus_tag="BSU36260" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12970183, 23939619, 24493247, 26283769" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12970183, 23939619, 24493247, 26283769; Product type r: regulator" /codon_start=1 /transl_table=11 /product="modulator of PtkA protein tyrosine kinase activity; modulation of biofilm formation" /protein_id="NP_391507.1" /db_xref="EnsemblGenomes-Gn:BSU36260" /db_xref="EnsemblGenomes-Tr:CAB15643" /db_xref="GOA:P96715" /db_xref="InterPro:IPR003856" /db_xref="InterPro:IPR032807" /db_xref="SubtiList:BG12507" /db_xref="UniProtKB/Swiss-Prot:P96715" /translation="MGESTSLKEILSTLTKRILLIMIVTAAATAAGGLISFFALTPIY ENSTQILVNQSKNERKEVQFNDVQTNLQLINTYNVIIKSPAILDEVIKEMGLSMTSQE LNDKITVSSEQDSQVVNISVRDENAETAAHIANTIASVFQDKITSIMNVDNVSILSKA EVSEHPSPVSPKPLLNIAIAFAAGLAGSIGLAFLLEHLDNTIKSEEQLESLLDIPVLG TVSTIANEQKTAKTLQGFQSEKTGSGHFGA*" /label="tkmA CDS" gene complement(3356848..3357594) /gene="tkmA" /locus_tag="BSU_36260" /old_locus_tag="BSU36260" /label="tkmA gene" promotor_-10 complement(3357626..3357645) /Source="Nicolas_upshift_promotors" /id="U2838" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.513486513486514" /psig=1 /xcortree=2281 /SigmaFactorBS="gtaaaaaaatgtcgaattatgtcacgtgaaaagCTGGagaaa tgcggtttcaaCGTTGTATAATCGTAGATGGaaaaggatgttataagagatttggagg t" /listShort="ywqC, ptkA, ywqE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3357638) /Source="Nicolas_upshifts" /id="U2838" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.513486513486514" /psig=1 /xcortree=2281 /SigmaFactorBS="gtaaaaaaatgtcgaattatgtcacgtgaaaagCTGGagaaa tgcggtttcaaCGTTGTATAATCGTAGATGGaaaaggatgttataagagatttggagg t" /listShort="ywqC, ptkA, ywqE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3357662..3357665) /Source="Nicolas_upshift_promotors" /id="U2838" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.513486513486514" /psig=1 /xcortree=2281 /SigmaFactorBS="gtaaaaaaatgtcgaattatgtcacgtgaaaagCTGGagaaa tgcggtttcaaCGTTGTATAATCGTAGATGGaaaaggatgttataagagatttggagg t" /listShort="ywqC, ptkA, ywqE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3357828..3357971) /gene="ywzD" /locus_tag="BSU_36269" /old_locus_tag="BSU36269" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20709900" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097792.1" /db_xref="EnsemblGenomes-Gn:BSU36269" /db_xref="EnsemblGenomes-Tr:CAX52703" /db_xref="UniProtKB/Swiss-Prot:C0H3S3" /translation="MSEKKLNQEEFLKILMHAHEIGEQSSEMTTKEMLENLISHIKNG YAT*" /label="ywzD CDS" gene complement(3357828..3357971) /gene="ywzD" /locus_tag="BSU_36269" /old_locus_tag="BSU36269" /label="ywzD gene" downshifts complement(3357849) /Source="Nicolas_upshifts" /id="D1875" /incds=0 /nref=221 /ntot=264 /MaxReadThrough="2.76798" /MaxDrop="8.13076" /score="15.8630799" /energy="-9.3" /TU="U2839" /idTUdmin="U2841" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3357972..3358057) /Source="Nicolas_S_feature" /locus_tag="new_3733649_3733734_c" /HighExp="S6, S8, S7, MG-0.2, S5, M9-stat, MG-0.1, MG 25, T0.30H, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigD, SigK" /TUshortPSig="0.275, 1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1395" misc_feature complement(3358047..3358058) /Source="Nicolas_upshift_promotors" /id="U2839" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.290709290709291" /psig="0.274725274725275" /xcortree=1473 /SigmaFactorBS="caacacatcggccttaaaaagtttttcctaaaaaaggacata aaaaataggatgtgtcgAATGATGTATTAgagattgcaaattgataaccagcatcata t" /listShort="S1395, ywzD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3358057) /Source="Nicolas_upshifts" /id="U2839" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.290709290709291" /psig="0.274725274725275" /xcortree=1473 /SigmaFactorBS="caacacatcggccttaaaaagtttttcctaaaaaaggacata aaaaataggatgtgtcgAATGATGTATTAgagattgcaaattgataaccagcatcata t" /listShort="S1395, ywzD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3358059..3358289) /Source="Nicolas_S_feature" /locus_tag="new_3733736_3733966_c" /HighExp="S6, S8, S7, S5, BT, Cold, LBGstat, LPhT, Pyr, C30" /AntisenseName="ywqB" /AntisenseCor="3.4267833233812203E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigK" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1396" promotor_-35 3358096..3358100 /Source="Nicolas_upshift_promotors" /id="U2840" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2581 /SigmaFactorBS="atcctattttttatgtccttttttaggaaaaACTTTttaagg ccgatgtgtTGCGATATAATAGAGAAATTggatctttttattacgtgactcggttagg a" /listShort="ywqB, ywqA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3358116..3358135 /Source="Nicolas_upshift_promotors" /id="U2840" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2581 /SigmaFactorBS="atcctattttttatgtccttttttaggaaaaACTTTttaagg ccgatgtgtTGCGATATAATAGAGAAATTggatctttttattacgtgactcggttagg a" /listShort="ywqB, ywqA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3358125 /Source="Nicolas_upshifts" /id="U2840" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2581 /SigmaFactorBS="atcctattttttatgtccttttttaggaaaaACTTTttaagg ccgatgtgtTGCGATATAATAGAGAAATTggatctttttattacgtgactcggttagg a" /listShort="ywqB, ywqA" /GFF_Attribute="listLong" /label="upshifts" CDS 3358175..3359785 /gene="ywqB" /locus_tag="BSU_36270" /old_locus_tag="BSU36270" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative replication initiation protein" /protein_id="NP_391508.2" /db_xref="EnsemblGenomes-Gn:BSU36270" /db_xref="EnsemblGenomes-Tr:CAB15644" /db_xref="GOA:P96714" /db_xref="InterPro:IPR007527" /db_xref="SubtiList:BG12506" /db_xref="UniProtKB/Swiss-Prot:P96714" /translation="MLQNMISKDDVLASAEQLKELLPYNEENVQLIKKALILYRQDSV YRLQAVSPTEVTAYVQDVVPVRVTLNLFVIVKSGCSCPSGRICRHMLAVFLYVYAMFE RVGTFTEYWLEREKLEESKELVRRQFQEKVLPNEESLSSWLAFFDSEFSLWQARTPEG SQNMQGLYYGYLSALKKHAPNKPELKSLYQIHSAIAVWLRMFTLIEAGKLNPEQDFYS LNPYVEQLMDTIYSSIDKLKTYALSFALDPFLDKTPDVIRHLLLKEEIFQYERIRVFG EIWSALLSRPKWVAREQEILKKEAGRRFSPELQFGRLHLEFLQKNDDVIFEEADQFPP EALPYTFQWLSEMTAKKDWKRLKTWYQQIEPIAMGYTKLDKPFKEIRDVIGELFLLLN AYVQQTNDQALFERFAAGCLPYTFTEYSHHLYEKKRYAEWIEIHSLVGFSINEMDKMM LKEIAASDPEALIPAYHREVAFFIDQKNRSSYKEAARYLKKLRTLYKKAKKQKVWERY IQLLSSHYKRLRALQEELQKGKLIDGES*" /label="ywqB CDS" gene 3358175..3359785 /gene="ywqB" /locus_tag="BSU_36270" /old_locus_tag="BSU36270" /label="ywqB gene" promotor_-10 complement(3358277..3358295) /Source="Nicolas_upshift_promotors" /id="U2841" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2784 /SigmaFactorBS="cgtaagccgtaacttccgtcggactcactgcttGTAAACGAt agactgaatcctGCCGATATAAAATAAGGGCttttttgatcagctgaacattttcctc a" /listShort="S1396, S1395, ywzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3358289) /Source="Nicolas_upshifts" /id="U2841" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2784 /SigmaFactorBS="cgtaagccgtaacttccgtcggactcactgcttGTAAACGAt agactgaatcctGCCGATATAAAATAAGGGCttttttgatcagctgaacattttcctc a" /listShort="S1396, S1395, ywzD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3358291..3358465) /Source="Nicolas_S_feature" /locus_tag="new_3733968_3734142_c" /HighExp="S6, S8, S7, S5, BT, B36, G/S, Pyr, B60, C30" /AntisenseName="ywqB" /AntisenseCor="-0.10880748846525" /AntisenseRegPval="-1.1000000000000001" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1397" promotor_-35 complement(3358309..3358316) /Source="Nicolas_upshift_promotors" /id="U2841" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2784 /SigmaFactorBS="cgtaagccgtaacttccgtcggactcactgcttGTAAACGAt agactgaatcctGCCGATATAAAATAAGGGCttttttgatcagctgaacattttcctc a" /listShort="S1396, S1395, ywzD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3358452..3358471) /Source="Nicolas_upshift_promotors" /id="U2842" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1319 /SigmaFactorBS="aagcttttccctctccagccaatactctgtaaAAGTACCCAc tcgctcgaacatTGCATATACATATAAAAACAcagccagcatatggcggcagattctt c" /listShort="S1397, S1396, S1395, ywzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3358465) /Source="Nicolas_upshifts" /id="U2842" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1319 /SigmaFactorBS="aagcttttccctctccagccaatactctgtaaAAGTACCCAc tcgctcgaacatTGCATATACATATAAAAACAcagccagcatatggcggcagattctt c" /listShort="S1397, S1396, S1395, ywzD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3358485..3358493) /Source="Nicolas_upshift_promotors" /id="U2842" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1319 /SigmaFactorBS="aagcttttccctctccagccaatactctgtaaAAGTACCCAc tcgctcgaacatTGCATATACATATAAAAACAcagccagcatatggcggcagattctt c" /listShort="S1397, S1396, S1395, ywzD" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3359772..3362540 /gene="hepA" /locus_tag="BSU_36280" /old_locus_tag="BSU36280" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9507009, 9614128, 11751638, 17913745, 19282450; Product type f: factor" /codon_start=1 /transl_table=11 /product="ATPase involved in RNA remodelling DNA recombination and repair" /protein_id="NP_391509.1" /db_xref="EnsemblGenomes-Gn:BSU36280" /db_xref="EnsemblGenomes-Tr:CAB15645" /db_xref="GOA:P94593" /db_xref="InterPro:IPR000330" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR022138" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12505" /db_xref="UniProtKB/Swiss-Prot:P94593" /translation="MASLKEILIHVEQMEDGSFTLSAFDENEQPLPYSHMKKHLFQWH ESSFYGTFLEDVSFIGTTAVLLSPWMTVELLGKNSFNSFSSVQLTEETEPLIEAASTI YEFIADGDFMPDYDAWTNGVFRWKDRDNILEGFTAEWFSAAVQDYIQYDDDLREKWEH IKEKSPAVTTFRGHFLDEEDFLEGIGWIDDQSPFTVGLRLNEPDFDGDEWKIEMFLRD KKSGAVEFFDGLKSLKKSWQAYSDKIAREQDRFHRTVPWLSFDSGTTLISEEEAWIFL SEASETLVDMGVEILLPSWWQIVRDSNMMLKAKVSSSPRGESFVGMNALLDFNWRFAT NGIELTEAEFNELVASNRRLVNIRGQWVKIDPQFIKQMKRLMEKAESEGLHMSDILAR ELMDQQDGGLEDSDLIDTSAFAGIQFDLSKQLRSLIRKLTAAENLPEHKVSPSFKGTL RPYQKYGMNWLLFLRESGFGACLADDMGLGKTIQMIAYFLHVKESGRQKTPHLIIAPT SVLGNWQRELQTFAPDLSVALHYGPRRPKGDDFAAHYENADVVLTSYGLSHADTEELS SVTWNTICLDEAQNIKNAHTKQSRAIRKLKGLHHIALSGTPMENRLTELWSIFDFMNK GYLGSLTGFHKRYVLPIEKDRDEKRIGQLQQLIRPFLLRRTKRDEEVALNLPEKLEEK EFIPLSAEQASLYEQLVKDTFDHMTSLTGMQRKALILSMLGRLKQICDHPALYLKEEQ TELLAGRSVKLEKLLELMTAIRAQNESCLIFTQYIQMGNMMKRLLEKTFGEPVQFLNG SLSKQERDTLVEKFQRKEYPTLILSLKAGGTGLNLTAANHVIHYDRWWNPAVENQATD RAYRIGQERFVHVHKMITTGTIEEKIDVMLESKQTLNDQIIQSENWITELSTQELEEL FTLSATAQ*" /label="hepA CDS" gene 3359772..3362540 /gene="hepA" /locus_tag="BSU_36280" /old_locus_tag="BSU36280" /label="hepA gene" downshifts complement(3362589) /Source="Nicolas_upshifts" /id="D1876" /incds=0 /nref=9 /ntot=202 /MaxReadThrough="1.80101" /MaxDrop="4.14573" /score="30.708119" /energy="-14.4" /TU="U2843" /idTUdmin="U2844" /TUdmin=12 /isTUend="TRUE" /label="downshifts" CDS complement(3362666..3363523) /gene="ywpJ" /locus_tag="BSU_36290" /old_locus_tag="BSU36290" /EC_number="3.1.3.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 25848029; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphatase of unidentified specificity (possibly promiscuous)" /protein_id="NP_391510.1" /db_xref="EnsemblGenomes-Gn:BSU36290" /db_xref="EnsemblGenomes-Tr:CAB15646" /db_xref="GOA:P94592" /db_xref="InterPro:IPR000150" /db_xref="InterPro:IPR006379" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="PDB:1NRW" /db_xref="SubtiList:BG12504" /db_xref="UniProtKB/Swiss-Prot:P94592" /translation="MKLIAIDLDGTLLNSKHQVSLENENALRQAQRDGIEVVVSTGRA HFDVMSIFEPLGIKTWVISANGAVIHDPEGRLYHHETIDKKRAYDILSWLESENYYYE VFTGSAIYTPQNGRELLDVELDRFRSANPEADLSVLKQAAEVQYSQSGFAYINSFQEL FEADEPIDFYNILGFSFFKEKLEAGWKRYEHAEDLTLVSSAEHNFELSSRKASKGQAL KRLAKQLNIPLEETAAVGDSLNDKSMLEAAGKGVAMGNAREDIKSIADAVTLTNDEHG VAHMMKHLL*" /label="ywpJ CDS" gene complement(3362666..3363523) /gene="ywpJ" /locus_tag="BSU_36290" /old_locus_tag="BSU36290" /label="ywpJ gene" CDS complement(3363529..3364305) /gene="glcR" /locus_tag="BSU_36300" /old_locus_tag="BSU36300" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11491085" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11491085; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (glucose repression ofcatabolic operons)" /protein_id="NP_391511.1" /db_xref="EnsemblGenomes-Gn:BSU36300" /db_xref="EnsemblGenomes-Tr:CAB15647" /db_xref="GOA:P94591" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR014036" /db_xref="InterPro:IPR018356" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12503" /db_xref="UniProtKB/Swiss-Prot:P94591" /translation="MYQEERLVAILDFLKQHNRITTEQICTLLQVSRDTARRDLVKLE EQNAIIRTRGGAILPTVHQKIQSYSGRLKTVSEEKNKIGRLAASLIHDGDRVILDAST TVQACAKHLNAVDCTVITNSINLADVLSDKEGIEIYLLGGKLEKEHRFLYGSSVIEKL SSYHVDKALIGVVGISEHGITIAHEEDGMVKRKMIQQAKQVIALADHSKLGSTSFYQY AELNEIDLLITDRLPNQAFCDLLDRNGVELLVTEQDEGKD*" /label="glcR CDS" gene complement(3363529..3364305) /gene="glcR" /locus_tag="BSU_36300" /old_locus_tag="BSU36300" /label="glcR gene" promotor_-10 complement(3364331..3364350) /Source="Nicolas_upshift_promotors" /id="U2843" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=3012 /SigmaFactorBS="ttggttctctcgacgcatttttacttaaaatcacttattaaT GTTGAATaaaatcaaataaaaACTTATAATTACTTATAAATgattgctgagaaaagga a" /listShort="glcR, ywpJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3364353) /Source="Nicolas_upshifts" /id="U2843" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=3012 /SigmaFactorBS="ttggttctctcgacgcatttttacttaaaatcacttattaaT GTTGAATaaaatcaaataaaaACTTATAATTACTTATAAATgattgctgagaaaagga a" /listShort="glcR, ywpJ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3364355..3364427) /Source="Nicolas_S_feature" /locus_tag="new_3740032_3740104_c" /HighExp="C30, GM 150, T-4.40H, G/S, C90, S2, T-5.40H, T-3.40H, T-2.40H, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1398" promotor_-35 complement(3364365..3364372) /Source="Nicolas_upshift_promotors" /id="U2843" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=3012 /SigmaFactorBS="ttggttctctcgacgcatttttacttaaaatcacttattaaT GTTGAATaaaatcaaataaaaACTTATAATTACTTATAAATgattgctgagaaaagga a" /listShort="glcR, ywpJ" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3364429..3364528) /Source="Nicolas_S_feature" /locus_tag="new_3740106_3740205_c" /HighExp="HiOs, S2, T-3.40H, T0.30H, C90, G/S, T1.0H, T0.0H, Pyr, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1399" downshifts complement(3364472) /Source="Nicolas_upshifts" /id="D1877" /incds=0 /nref=221 /ntot=258 /MaxReadThrough="3.81096" /MaxDrop="7.17295" /score="-7.00620083" /energy="-7.5" /TU="U2844" /idTUdmin="U2846" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(3364529..3364870) /gene="ssbB" /locus_tag="BSU_36310" /old_locus_tag="BSU36310" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:14762004, 16009133, 16549871, 17630974, 25138221" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14762004, 16009133, 16549871, 17630974, 25138221; Product type f: factor" /codon_start=1 /transl_table=11 /product="single-strand DNA-binding protein" /protein_id="NP_391512.2" /db_xref="EnsemblGenomes-Gn:BSU36310" /db_xref="EnsemblGenomes-Tr:CAB15648" /db_xref="GOA:C0SPB6" /db_xref="InterPro:IPR000424" /db_xref="InterPro:IPR011344" /db_xref="InterPro:IPR012340" /db_xref="PDB:3VDY" /db_xref="SubtiList:BG12502" /db_xref="UniProtKB/Swiss-Prot:C0SPB6" /translation="MFNQVMLVGRLTKDPDLRYTSAGAAVAHVTLAVNRSFKNASGEI EADYVNCTLWRKTAENTALYCQKGSLVGVSGRIQTRSYENEEGVNVYVTEVLADTVRF MDPKPREKAAD*" /label="ssbB CDS" gene complement(3364529..3364870) /gene="ssbB" /locus_tag="BSU_36310" /old_locus_tag="BSU36310" /label="ssbB gene" promotor_-10 complement(3364892..3364911) /Source="Nicolas_upshift_promotors" /id="U2844" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.89010989010989" /psig=1 /xcortree=2964 /SigmaFactorBS="aacgaaagataaaaacagaggctgaaagccatttttaagCGT TTTTCttttcttgttgcaTCATTTACAATACATACAACcgcaaggagaggaggaatcg c" /listShort="ssbB, S1399, S1398, glcR, ywpJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3364911) /Source="Nicolas_upshifts" /id="U2844" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.89010989010989" /psig=1 /xcortree=2964 /SigmaFactorBS="aacgaaagataaaaacagaggctgaaagccatttttaagCGT TTTTCttttcttgttgcaTCATTTACAATACATACAACcgcaaggagaggaggaatcg c" /listShort="ssbB, S1399, S1398, glcR, ywpJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3364925..3364932) /Source="Nicolas_upshift_promotors" /id="U2844" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.89010989010989" /psig=1 /xcortree=2964 /SigmaFactorBS="aacgaaagataaaaacagaggctgaaagccatttttaagCGT TTTTCttttcttgttgcaTCATTTACAATACATACAACcgcaaggagaggaggaatcg c" /listShort="ssbB, S1399, S1398, glcR, ywpJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3364947..3365330) /gene="ywpG" /locus_tag="BSU_36320" /old_locus_tag="BSU36320" /experiment="publication(s) with functional evidences, PMID:23060960" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23060960; Product type f: factor" /codon_start=1 /transl_table=11 /product="interaction partner of DynA" /protein_id="NP_391513.1" /db_xref="EnsemblGenomes-Gn:BSU36320" /db_xref="EnsemblGenomes-Tr:CAB15649" /db_xref="SubtiList:BG12501" /db_xref="UniProtKB/Swiss-Prot:P94589" /translation="MNQFRLKEIYIDGVPSESHLIQKEVTYMLSRKEVFEVHLNKKGR ISFLYETQDGMEQYKIKLSMPEKKLSFQWFAWDGSSYVRMNTQNWLTKQIFFRFLKST YFFKGKKQKMFLAEGKMKTKDKNRG*" /label="ywpG CDS" gene complement(3364947..3365330) /gene="ywpG" /locus_tag="BSU_36320" /old_locus_tag="BSU36320" /label="ywpG gene" promotor_-10 complement(3365352..3365371) /Source="Nicolas_upshift_promotors" /id="U2846" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2300 /SigmaFactorBS="cctgcaatgttggggctaaagaattttgtatgagcgaaaCAT TTAATaatttctattttttCATTATACTGTAACTGACTAtggattacggagagatgtg g" /listShort="ywpG, ssbB, S1399" /listLong="S1398, glcR, ywpJ" /label="promotor_-10" misc_feature 3365359..3365378 /Source="Nicolas_upshift_promotors" /id="U2845" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.502497502497502" /psig="0.973026973026973" /xcortree=3123 /SigmaFactorBS="aaatttcttttaaacgaaattgattcataccacatctctccg taatccatagtcagTTACAGTATAATGAAAAAATagaaattattaaatgtttcgctca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3365363 /Source="Nicolas_upshifts" /id="U2845" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.502497502497502" /psig="0.973026973026973" /xcortree=3123 /SigmaFactorBS="aaatttcttttaaacgaaattgattcataccacatctctccg taatccatagtcagTTACAGTATAATGAAAAAATagaaattattaaatgtttcgctca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3365372) /Source="Nicolas_upshifts" /id="U2846" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2300 /SigmaFactorBS="cctgcaatgttggggctaaagaattttgtatgagcgaaaCAT TTAATaatttctattttttCATTATACTGTAACTGACTAtggattacggagagatgtg g" /listShort="ywpG, ssbB, S1399" /listLong="S1398, glcR, ywpJ" /label="upshifts" promotor_-35 complement(3365386..3365393) /Source="Nicolas_upshift_promotors" /id="U2846" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2300 /SigmaFactorBS="cctgcaatgttggggctaaagaattttgtatgagcgaaaCAT TTAATaatttctattttttCATTATACTGTAACTGACTAtggattacggagagatgtg g" /listShort="ywpG, ssbB, S1399" /listLong="S1398, glcR, ywpJ" /label="promotor_-35" misc_feature 3365453..3365472 /Source="Nicolas_upshift_promotors" /id="U2847" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.818181818181818" /psig=1 /xcortree=1915 /SigmaFactorBS="tcgctcatacaaaattctttagccccaacattgcaggatttt ttcctcgaaaacgttTATGTTATAATGGAAGGCAAgaaaactttggaagtaatcgggg t" /listShort="ywpF" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3365456 /Source="Nicolas_upshifts" /id="U2847" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.818181818181818" /psig=1 /xcortree=1915 /SigmaFactorBS="tcgctcatacaaaattctttagccccaacattgcaggatttt ttcctcgaaaacgttTATGTTATAATGGAAGGCAAgaaaactttggaagtaatcgggg t" /listShort="ywpF" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(3365505) /Source="Nicolas_upshifts" /id="D1878" /incds=0 /nref=2 /ntot=169 /MaxReadThrough="0.85282" /MaxDrop="4.02798" /score="27.231517" /energy="-14" /TU="NA" /idTUdmin="U2846" /TUdmin="-1034" /isTUend="FALSE" /label="downshifts" CDS 3365505..3365915 /gene="ywpF" /locus_tag="BSU_36330" /old_locus_tag="BSU36330" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 25663006" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391514.1" /db_xref="EnsemblGenomes-Gn:BSU36330" /db_xref="EnsemblGenomes-Tr:CAB15650" /db_xref="InterPro:IPR025573" /db_xref="SubtiList:BG12500" /db_xref="UniProtKB/Swiss-Prot:P94588" /translation="MKTFKLVDLNVERVDKEEQSIEQFPLIDGLIINKEDGENHWLIE ALVQKEHLSFFEQLQNSQSEAKVFVTITKKSNRPAQLTAAVKNIVKLEESIQVLLYGQ MVTRKQQGTETILESLVKEGYTGTKLIEAFKQKL*" /label="ywpF CDS" gene 3365505..3365915 /gene="ywpF" /locus_tag="BSU_36330" /old_locus_tag="BSU36330" /label="ywpF gene" S_feature 3365916..3365999 /Source="Nicolas_S_feature" /locus_tag="new_3741593_3741676" /HighExp="BC, LBGtran, T3.30H, Etha, T2.0H, Lbtran, M9-stat, T3.0H, dia5, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1400" downshifts 3365957 /Source="Nicolas_upshifts" /id="D1879" /incds=0 /nref=214 /ntot=260 /MaxReadThrough="1.83981" /MaxDrop="6.19197" /score="18.4023831" /energy="-14" /TU="NA" /idTUdmin="U2847" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3366055..3366363) /gene="ywpE" /locus_tag="BSU_36340" /old_locus_tag="BSU36340" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15187182, 21800427, 21906378; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sortase" /protein_id="NP_391515.1" /db_xref="EnsemblGenomes-Gn:BSU36340" /db_xref="EnsemblGenomes-Tr:CAB15651" /db_xref="GOA:P94587" /db_xref="InterPro:IPR005754" /db_xref="InterPro:IPR023365" /db_xref="SubtiList:BG12499" /db_xref="UniProtKB/Swiss-Prot:P94587" /translation="MRRDQKMGEGNYPLAGHHLKQKNLLFGPLENIKTGAQIVITDFK KDYIYSVTSKDIISEMDADVVEETNKKEITLITCDKAVKTEGRLVVKGELVDSFGHTN *" /label="ywpE CDS" gene complement(3366055..3366363) /gene="ywpE" /locus_tag="BSU_36340" /old_locus_tag="BSU36340" /label="ywpE gene" downshifts complement(3366056) /Source="Nicolas_upshifts" /id="D1880" /incds=0 /nref=1 /ntot=36 /MaxReadThrough="0.11027" /MaxDrop="2.8132" /score="27.231517" /energy="-14" /TU="NA" /idTUdmin="U2849" /TUdmin=1540 /isTUend="FALSE" /label="downshifts" CDS 3366707..3367543 /gene="ywpD" /locus_tag="BSU_36350" /old_locus_tag="BSU36350" /function="16.12: Sense" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16740923; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="putative two-component sensor histidine kinase" /protein_id="NP_391516.1" /db_xref="EnsemblGenomes-Gn:BSU36350" /db_xref="EnsemblGenomes-Tr:CAB15652" /db_xref="GOA:P94586" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR010559" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12498" /db_xref="UniProtKB/Swiss-Prot:P94586" /translation="MKIRERFSMVDLPVLIITAAIIGHDKYKAFHAGANDILQKPYHY SEFMARIQNLIMMKHTANQATRMEMAFLQSQIKPHFLYNVLNTIISLTHLDIEKAREV TEEFTNYLRMSFDFQNTSAISSFRHELSIINSYLSIEKTRFSNRLEVLFDIDEDIDFI LPPLMIQPLVENAVLHGVSKKRGGGWIKLTAKKQSKNEYHIKVEDNGPGITPEKQIDL LSTDFDRSVGLKNINQRLKHFCGSELMISSTPDAGTSVSMLIHLAETTGSPKELKDTE RT*" /label="ywpD CDS" gene 3366707..3367543 /gene="ywpD" /locus_tag="BSU_36350" /old_locus_tag="BSU36350" /label="ywpD gene" promotor_-35 3366923..3366930 /Source="Nicolas_upshift_promotors" /id="U2848" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.81918081918082" /psig="0.993006993006993" /xcortree=642 /SigmaFactorBS="caaatcaagccacaagaatggaaatggcgtttctcCAGTCGC AaatcaagcctcattTTCTTTATAATGTATTAAACacgattatttctctcactcattt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3366945..3366964 /Source="Nicolas_upshift_promotors" /id="U2848" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.81918081918082" /psig="0.993006993006993" /xcortree=642 /SigmaFactorBS="caaatcaagccacaagaatggaaatggcgtttctcCAGTCGC AaatcaagcctcattTTCTTTATAATGTATTAAACacgattatttctctcactcattt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3366948 /Source="Nicolas_upshifts" /id="U2848" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.81918081918082" /psig="0.993006993006993" /xcortree=642 /SigmaFactorBS="caaatcaagccacaagaatggaaatggcgtttctcCAGTCGC AaatcaagcctcattTTCTTTATAATGTATTAAACacgattatttctctcactcattt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 3367542 /Source="Nicolas_upshifts" /id="D1881" /incds=0 /nref=13 /ntot=132 /MaxReadThrough="0.11837" /MaxDrop="3.37937" /score="9.16906941" /energy="-8.6" /TU="NA" /idTUdmin="U2848" /TUdmin=154 /isTUend="FALSE" /label="downshifts" CDS complement(3367590..3367982) /gene="mscL" /locus_tag="BSU_36360" /old_locus_tag="BSU36360" /function="16.1: Circulate" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12948773, 15063854, 15165739, 16897034, 22685134, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12948773, 15063854, 15165739, 16897034, 22685134, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="large conductance mechanosensitive channel protein" /protein_id="NP_391517.1" /db_xref="EnsemblGenomes-Gn:BSU36360" /db_xref="EnsemblGenomes-Tr:CAB15653" /db_xref="GOA:P94585" /db_xref="InterPro:IPR001185" /db_xref="InterPro:IPR019823" /db_xref="InterPro:IPR036019" /db_xref="SubtiList:BG12497" /db_xref="UniProtKB/Swiss-Prot:P94585" /translation="MWNEFKAFAMRGNIVDLAIGVVIGGAFGKIVTSLVNDIIMPLVG LLLGGLDFSGLSFTFGDAVVKYGSFIQTIVNFLIISFSIFIVIRTLNGLRRKKEAEEE AAEEAVDAQEELLKEIRDLLKQQAKSPE*" /label="mscL CDS" gene complement(3367590..3367982) /gene="mscL" /locus_tag="BSU_36360" /old_locus_tag="BSU36360" /label="mscL gene" downshifts complement(3367596) /Source="Nicolas_upshifts" /id="D1882" /incds=0 /nref=216 /ntot=255 /MaxReadThrough="2.23487" /MaxDrop="6.5103" /score="28.9904077" /energy="-11.4" /TU="NA" /idTUdmin="U2849" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3368055..3368480) /gene="fabZ" /locus_tag="BSU_36370" /old_locus_tag="BSU36370" /EC_number="4.2.1.59" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8910376, 12682299, 15194690, 15371447, 18093984, 22580319, 23322253, 27874013; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="beta-hydroxyacyl-[acyl carrier protein] dehydratase" /protein_id="NP_391518.2" /db_xref="EnsemblGenomes-Gn:BSU36370" /db_xref="EnsemblGenomes-Tr:CAB15654" /db_xref="GOA:P94584" /db_xref="InterPro:IPR010084" /db_xref="InterPro:IPR013114" /db_xref="InterPro:IPR029069" /db_xref="SubtiList:BG12496" /db_xref="UniProtKB/Swiss-Prot:P94584" /translation="MLDTQQIKEIIPHRYPFLLVDRITEVEEGKRAKGYKNVTANEEF FNGHFPQYPVMPGVLIVEALAQVGAVAMLIKEENRGRLAFFAGIDNCRFKKQVKPGDQ LHLEVEIIRARGTIGRGKGVATVDGEVVCEVELTFALGE*" /label="fabZ CDS" gene complement(3368055..3368480) /gene="fabZ" /locus_tag="BSU_36370" /old_locus_tag="BSU36370" /label="fabZ gene" promotor_-10 complement(3368541..3368560) /Source="Nicolas_upshift_promotors" /id="U2849" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2557 /SigmaFactorBS="acggctctcattgacagttggttacattttagcgcGGTTGAA AaagagattaattcaTAATATACTTTTCAAATGTAcagattggatctttgatgattgc t" /listShort="fabZ, mscL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3368557) /Source="Nicolas_upshifts" /id="U2849" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2557 /SigmaFactorBS="acggctctcattgacagttggttacattttagcgcGGTTGAA AaagagattaattcaTAATATACTTTTCAAATGTAcagattggatctttgatgattgc t" /listShort="fabZ, mscL" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3368559..3368643) /Source="Nicolas_S_feature" /locus_tag="new_3744236_3744320_c" /HighExp="Diami, dia5, Cold, dia15, H2O2, C30, Etha, Oxctl, Paraq, M/G" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="SigD, SigA" /TUlongPSig="0.999, 0.837" /label="S1401" promotor_-35 complement(3368575..3368582) /Source="Nicolas_upshift_promotors" /id="U2849" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2557 /SigmaFactorBS="acggctctcattgacagttggttacattttagcgcGGTTGAA AaagagattaattcaTAATATACTTTTCAAATGTAcagattggatctttgatgattgc t" /listShort="fabZ, mscL" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3368622 /Source="Nicolas_upshifts" /id="U2850" /multdbtbs="SigA,SigX" /comp="M4" /sig="SigA" /pcomp="0.956043956043956" /psig="0.988011988011988" /xcortree=3190 /SigmaFactorBS="gaattaatctctttttcaaccgcgctaaaatgtaaccaactg tcaatgagagccgtcaaaagtTATGATATGATAATTATAGAttttaccaatagcaaag a" /listShort="rapD, S1403" /GFF_Attribute="listLong" /label="upshifts" misc_feature 3368625..3368644 /Source="Nicolas_upshift_promotors" /id="U2850" /multdbtbs="SigA,SigX" /comp="M4" /sig="SigA" /pcomp="0.956043956043956" /psig="0.988011988011988" /xcortree=3190 /SigmaFactorBS="gaattaatctctttttcaaccgcgctaaaatgtaaccaactg tcaatgagagccgtcaaaagtTATGATATGATAATTATAGAttttaccaatagcaaag a" /listShort="rapD, S1403" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(3368635..3368654) /Source="Nicolas_upshift_promotors" /id="U2851" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.995004995004995" /xcortree=1970 /SigmaFactorBS="agcattcttttttcaataaacttcgaaatcATTTTCctacct ctttgctATTGGTAAAATCTATAATTAtcatatcataacttttgacggctctcattga c" /listShort="S1401" /listLong="fabZ, mscL" /label="promotor_-10" upshifts complement(3368643) /Source="Nicolas_upshifts" /id="U2851" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.995004995004995" /xcortree=1970 /SigmaFactorBS="agcattcttttttcaataaacttcgaaatcATTTTCctacct ctttgctATTGGTAAAATCTATAATTAtcatatcataacttttgacggctctcattga c" /listShort="S1401" /listLong="fabZ, mscL" /label="upshifts" S_feature complement(3368645..3369729) /Source="Nicolas_S_feature" /locus_tag="new_3744322_3745406_c" /HighExp="Cold, C30, Lbstat, Glucon, Glu, Paraq, Pyr, H2O2, Fru, C90" /AntisenseName="rapD" /AntisenseCor="5.8390464430913601E-3" /AntisenseRegPval=0 /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig="0.999" /TUlongSig="SigA" /TUlongPSig="0.837" /label="S1402" promotor_-35 complement(3368668..3368673) /Source="Nicolas_upshift_promotors" /id="U2851" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.995004995004995" /xcortree=1970 /SigmaFactorBS="agcattcttttttcaataaacttcgaaatcATTTTCctacct ctttgctATTGGTAAAATCTATAATTAtcatatcataacttttgacggctctcattga c" /listShort="S1401" /listLong="fabZ, mscL" /label="promotor_-35" CDS 3368672..3369736 /gene="rapD" /locus_tag="BSU_36380" /old_locus_tag="BSU36380" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17227471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17227471; Product type r: regulator" /codon_start=1 /transl_table=11 /product="response regulator aspartate phosphatase" /protein_id="NP_391519.1" /db_xref="EnsemblGenomes-Gn:BSU36380" /db_xref="EnsemblGenomes-Tr:CAB15655" /db_xref="GOA:P94583" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="SubtiList:BG11967" /db_xref="UniProtKB/Swiss-Prot:P94583" /translation="MISKFIEKRMLNMLDEWYSAMSKRKMNHVCTLKEKIDQHLPKIK KNTKLWMRYQLFQARHQLLFENQNGLDSLFDGLYGLEDKMDDELKYYLYFFSGLYEMV KTAPKHAVHHFKKAEQYLAAIHNTFEAADLYYQTAGAYYLMKSPPLSVQYVKKALHIY LHQFGYIKKVITCKLLLAVNYIDQERYEKAEQLFKEIIKKTQQLHDENLLCHAYYNLG FLKATEKKDQEALLYFRKVLKNQEFEMNSPVSYLHCVYESVRALFKTGNITEAKAVLQ KGKELSEKVDIQTIYLKLKTLEALYTSAEDPYEQLLEYVLELEKIEAWVDLEVLLEDI TEYYKKKDDFEKAAFFIMRG*" /label="rapD CDS" gene 3368672..3369736 /gene="rapD" /locus_tag="BSU_36380" /old_locus_tag="BSU36380" /label="rapD gene" S_feature 3369737..3370621 /Source="Nicolas_S_feature" /locus_tag="new_3745414_3746298" /HighExp="M9-stat, T4.0H, T2.0H, T3.30H, T2.30H, T3.0H, T1.30H, T5.0H, T1.0H, T0.30H" /AntisenseName="flhP" /AntisenseCor="-0.32116112580252298" /AntisenseRegPval="-7.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S1403" CDS complement(3369759..3370568) /gene="flhP" /locus_tag="BSU_36390" /old_locus_tag="BSU36390" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:22730131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22730131; Product type s: structure" /codon_start=1 /transl_table=11 /product="flagellar hook-basal body accessory protein" /protein_id="NP_391520.2" /db_xref="EnsemblGenomes-Gn:BSU36390" /db_xref="EnsemblGenomes-Tr:CAB15656" /db_xref="GOA:P39753" /db_xref="InterPro:IPR001444" /db_xref="InterPro:IPR010930" /db_xref="InterPro:IPR019776" /db_xref="InterPro:IPR020013" /db_xref="SubtiList:BG10918" /db_xref="UniProtKB/Swiss-Prot:P39753" /translation="MLRSMLTASTTLNQLQQQIDTISSNLSNSNTTGYKAKDTNFSEL VRQQFDQVDEKNEEVAKARKTPPGLRLGVGAMMSSRLVSDQGSIQKTDRDLDIAFTSP YQYLQVNVNGNRQYTRDGALYVTPSAANANQLQLVTGNGYPVLDENGNTVNIDSSMKN ITINKNGTLTASDGNAVQRFNLGVVQVNNPQELKSEGNNLFSIDNAAAFEELNGANRQ NIGMQQGSLEMSNVDISEQMTDLITSQRSYQLNSRTITMGDQMLGLINSVR*" /label="flhP CDS" gene complement(3369759..3370568) /gene="flhP" /locus_tag="BSU_36390" /old_locus_tag="BSU36390" /label="flhP gene" downshifts complement(3369774) /Source="Nicolas_upshifts" /id="D1883" /incds=0 /nref=174 /ntot=256 /MaxReadThrough="4.65461" /MaxDrop="5.56507" /score="8.59904552" /energy="-7.4" /TU="U2853" /idTUdmin="U2854" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(3370602..3371414) /gene="flhO" /locus_tag="BSU_36400" /old_locus_tag="BSU36400" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1905667, 16621824, 22730131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1905667, 16621824, 22730131; Product type s: structure" /codon_start=1 /transl_table=11 /product="flagellar basal-body accessory rod protein" /protein_id="NP_391521.1" /db_xref="EnsemblGenomes-Gn:BSU36400" /db_xref="EnsemblGenomes-Tr:CAB15657" /db_xref="GOA:P39752" /db_xref="InterPro:IPR001444" /db_xref="InterPro:IPR010930" /db_xref="InterPro:IPR019776" /db_xref="SubtiList:BG10917" /db_xref="UniProtKB/Swiss-Prot:P39752" /translation="MLKGLYTATSAMIAQQRRTEMLSNNIANANTSGYKADQGSMRAF PEMLLSRIESKSPAGTSRTEIGSVNTGVYMQELKPLFTQGSLKSTDQPTDIALIENQV PMSAETNEKAALFYPVQTADGIRYSKSSTFSLNENNQLTINGRPILSTDRQPITVDNE NFTVSENGTVTTNGRTAGQIDVRMAEDVRNLKRDGNDLYSTADGNDLPSAAGNNQVAY SLKQGVSELSNVDVTSAYTEMTEAYRSFEANQKVIQAYDKSMDKAANEIGKI*" /label="flhO CDS" gene complement(3370602..3371414) /gene="flhO" /locus_tag="BSU_36400" /old_locus_tag="BSU36400" /label="flhO gene" S_feature complement(3371415..3371494) /Source="Nicolas_S_feature" /locus_tag="new_3747092_3747171_c" /HighExp="C90, Lbtran, Cold, GM-0.2, GM 15, GM 10, C30, GM 90, GM-0.1, MG 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA" /TUshortPSig="0.999, 0.837" /TUlongSig="NA" /TUlongPSig="NA" /label="S1404" promotor_-35 3371445..3371452 /Source="Nicolas_upshift_promotors" /id="U2852" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2095 /SigmaFactorBS="atttcccacctctaaaaatggcattttttcCAGTTGTCatat aggaacgttCGTTCTATAATAAAAACTCAgtattttatcctattatcgtcatttaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3371466..3371485 /Source="Nicolas_upshift_promotors" /id="U2852" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2095 /SigmaFactorBS="atttcccacctctaaaaatggcattttttcCAGTTGTCatat aggaacgttCGTTCTATAATAAAAACTCAgtattttatcctattatcgtcatttaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3371475 /Source="Nicolas_upshifts" /id="U2852" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2095 /SigmaFactorBS="atttcccacctctaaaaatggcattttttcCAGTTGTCatat aggaacgttCGTTCTATAATAAAAACTCAgtattttatcctattatcgtcatttaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3371488..3371506) /Source="Nicolas_upshift_promotors" /id="U2853" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2805 /SigmaFactorBS="aagaatgaggtttttttatgaaaaagcCTTCACGAaaagatg ttaaatGACGATAATAGGATAAAATactgagtttttattatagaacgaacgttcctat a" /listShort="S1404, flhO, flhP, S1402" /listLong="S1401, fabZ, mscL" /label="promotor_-10" upshifts complement(3371494) /Source="Nicolas_upshifts" /id="U2853" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2805 /SigmaFactorBS="aagaatgaggtttttttatgaaaaagcCTTCACGAaaagatg ttaaatGACGATAATAGGATAAAATactgagtttttattatagaacgaacgttcctat a" /listShort="S1404, flhO, flhP, S1402" /listLong="S1401, fabZ, mscL" /label="upshifts" promotor_-35 complement(3371520..3371527) /Source="Nicolas_upshift_promotors" /id="U2853" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2805 /SigmaFactorBS="aagaatgaggtttttttatgaaaaagcCTTCACGAaaagatg ttaaatGACGATAATAGGATAAAATactgagtttttattatagaacgaacgttcctat a" /listShort="S1404, flhO, flhP, S1402" /listLong="S1401, fabZ, mscL" /label="promotor_-35" CDS complement(3371577..3372578) /gene="mbl" /locus_tag="BSU_36410" /old_locus_tag="BSU36410" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11290328, 12530960, 14588250, 15745453, 17064365, 19659933, 21091501, 23879732, 27215790" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11290328, 12530960, 14588250, 15745453, 17064365, 19659933, 21091501, 23879732, 27215790; Product type f: factor" /codon_start=1 /transl_table=11 /product="MreB-like morphogen" /protein_id="NP_391522.2" /db_xref="EnsemblGenomes-Gn:BSU36410" /db_xref="EnsemblGenomes-Tr:CAB15658" /db_xref="GOA:P39751" /db_xref="InterPro:IPR004753" /db_xref="SubtiList:BG10916" /db_xref="UniProtKB/Swiss-Prot:P39751" /translation="MFARDIGIDLGTANVLIHVKGKGIVLNEPSVVALDKNSGKVLAV GEEARRMVGRTPGNIVAIRPLKDGVIADFEVTEAMLKHFINKLNVKGLFSKPRMLICC PTNITSVEQKAIKEAAEKSGGKHVYLEEEPKVAAIGAGMEIFQPSGNMVVDIGGGTTD IAVISMGDIVTSSSIKMAGDKFDMEILNYIKREYKLLIGERTAEDIKIKVATVFPDAR HEEISIRGRDMVSGLPRTITVNSKEVEEALRESVAVIVQAAKQVLERTPPELSADIID RGVIITGGGALLNGLDQLLAEELKVPVLVAENPMDCVAIGTGVMLDNMDKLPKRKLS* " /label="mbl CDS" gene complement(3371577..3372578) /gene="mbl" /locus_tag="BSU_36410" /old_locus_tag="BSU36410" /label="mbl gene" downshifts complement(3371583) /Source="Nicolas_upshifts" /id="D1884" /incds=0 /nref=108 /ntot=240 /MaxReadThrough="5.6154" /MaxDrop="4.18076" /score="20.122637" /energy="-11.2" /TU="U2854" /idTUdmin="U2855" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" misc_feature complement(3372633..3372652) /Source="Nicolas_upshift_promotors" /id="U2854" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.561438561438561" /psig="0.837162837162837" /xcortree=799 /SigmaFactorBS="gttcataaaacatccgcaaaaatttgtaaagaacttattgtg cttccaactttttttctatatttTATGATAATATATATAATTAgggcacaatgtggat a" /listShort="mbl, S1404, flhO, flhP" /listLong="S1402, S1401, fabZ, mscL" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3372657) /Source="Nicolas_upshifts" /id="U2854" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.561438561438561" /psig="0.837162837162837" /xcortree=799 /SigmaFactorBS="gttcataaaacatccgcaaaaatttgtaaagaacttattgtg cttccaactttttttctatatttTATGATAATATATATAATTAgggcacaatgtggat a" /listShort="mbl, S1404, flhO, flhP" /listLong="S1402, S1401, fabZ, mscL" /label="upshifts" S_feature complement(3372659..3372743) /Source="Nicolas_S_feature" /locus_tag="new_3748336_3748420_c" /HighExp="S5, S6, S4, S7, S8, S3, B36, T5.0H, B60, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1405" CDS complement(3372744..3373025) /gene="spoIIID" /locus_tag="BSU_36420" /old_locus_tag="BSU36420" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9023218, 9324264, 15598884, 22720735, 24584501" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9023218, 9324264, 15598884, 22720735, 24584501; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (stage III sporulation)" /protein_id="NP_391523.1" /db_xref="EnsemblGenomes-Gn:BSU36420" /db_xref="EnsemblGenomes-Tr:CAB15659" /db_xref="GOA:P15281" /db_xref="InterPro:IPR014208" /db_xref="InterPro:IPR018356" /db_xref="InterPro:IPR036388" /db_xref="PDB:2L0K" /db_xref="SubtiList:BG10408" /db_xref="UniProtKB/Swiss-Prot:P15281" /translation="MHDYIKERTIKIGKYIVETKKTVRVIAKEFGVSKSTVHKDLTER LPEINPDLANEVKEILDYHKSIRHLRGGEATKLKYKKDEILEGEPVQQS*" /label="spoIIID CDS" gene complement(3372744..3373025) /gene="spoIIID" /locus_tag="BSU_36420" /old_locus_tag="BSU36420" /label="spoIIID gene" CDS complement(3373040..3373150) /gene="usd" /locus_tag="BSU_36430" /old_locus_tag="BSU36430" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9023218; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="putative factor required for translation of spoIIID" /protein_id="NP_391524.1" /db_xref="EnsemblGenomes-Gn:BSU36430" /db_xref="EnsemblGenomes-Tr:CAB15660" /db_xref="SubtiList:BG11984" /db_xref="UniProtKB/Swiss-Prot:O32276" /translation="MGIFHKLTFKTIQRRSGIMNDSLQNTDLISHFSHPF*" /label="usd CDS" gene complement(3373040..3373150) /gene="usd" /locus_tag="BSU_36430" /old_locus_tag="BSU36430" /label="usd gene" promotor_-10 complement(3373181..3373199) /Source="Nicolas_upshift_promotors" /id="U2855" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1092 /SigmaFactorBS="atctgaaaaagttcgtttcaccccttgtccttattgagtttt tAGCATAttcccaaaagaatgcTAATACACTGTTACAAACCtaacaaagagagtgttt g" /listShort="usd, spoIIID, S1405, mbl" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3373203) /Source="Nicolas_upshifts" /id="U2855" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1092 /SigmaFactorBS="atctgaaaaagttcgtttcaccccttgtccttattgagtttt tAGCATAttcccaaaagaatgcTAATACACTGTTACAAACCtaacaaagagagtgttt g" /listShort="usd, spoIIID, S1405, mbl" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3373215..3373220) /Source="Nicolas_upshift_promotors" /id="U2855" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1092 /SigmaFactorBS="atctgaaaaagttcgtttcaccccttgtccttattgagtttt tAGCATAttcccaaaagaatgcTAATACACTGTTACAAACCtaacaaagagagtgttt g" /listShort="usd, spoIIID, S1405, mbl" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3373296..3373302 /Source="Nicolas_upshift_promotors" /id="U2856" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.347652347652348" /psig="0.98001998001998" /xcortree=305 /SigmaFactorBS="ctatttcgcgtcactaaattttcaTCTTTACaactattgatc gcTCCTGTAAAATGAAATAAGCaattagttacttaggtaagttttttagaaggagacc g" /listShort="ywoH, ywoG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3373316..3373335 /Source="Nicolas_upshift_promotors" /id="U2856" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.347652347652348" /psig="0.98001998001998" /xcortree=305 /SigmaFactorBS="ctatttcgcgtcactaaattttcaTCTTTACaactattgatc gcTCCTGTAAAATGAAATAAGCaattagttacttaggtaagttttttagaaggagacc g" /listShort="ywoH, ywoG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3373332 /Source="Nicolas_upshifts" /id="U2856" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.347652347652348" /psig="0.98001998001998" /xcortree=305 /SigmaFactorBS="ctatttcgcgtcactaaattttcaTCTTTACaactattgatc gcTCCTGTAAAATGAAATAAGCaattagttacttaggtaagttttttagaaggagacc g" /listShort="ywoH, ywoG" /GFF_Attribute="listLong" /label="upshifts" CDS 3373375..3373788 /gene="ywoH" /locus_tag="BSU_36440" /old_locus_tag="BSU36440" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)" /protein_id="NP_391525.1" /db_xref="EnsemblGenomes-Gn:BSU36440" /db_xref="EnsemblGenomes-Tr:CAB15661" /db_xref="GOA:P94578" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12495" /db_xref="UniProtKB/Swiss-Prot:P94578" /translation="MSYVNRHLIHQINQSARLIAKKANEQLEPFGLYSSQWSVLYCLR TIGPMTQKEIWSYLNVEAPTVTRTIKRLEENGWVQRRQGEDKREKLVVLTKEAEKKYE EINVKMLKFEEELLADFRDEDKEAFSHLFRMFLQQ*" /label="ywoH CDS" gene 3373375..3373788 /gene="ywoH" /locus_tag="BSU_36440" /old_locus_tag="BSU36440" /label="ywoH gene" CDS 3373810..3375000 /gene="ywoG" /locus_tag="BSU_36450" /old_locus_tag="BSU36450" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_391526.1" /db_xref="EnsemblGenomes-Gn:BSU36450" /db_xref="EnsemblGenomes-Tr:CAB15662" /db_xref="GOA:P94577" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12494" /db_xref="UniProtKB/Swiss-Prot:P94577" /translation="MKKADAIWTKDFIMVLLVNLFVFVFFYTFLTVLPIYTLQELGGT ESQGGLLISLFLLSAIITRPFSGAIVERFGKKRMAIVSMALFALSSFLYMPIHNFSLL LGLRFFQGIWFSILTTVTGAIAADIIPAKRRGEGLGYFAMSMNLAMAIGPFLGLNLMR VVSFPVFFTAFALFMVAGLLVSFLIKVPQSKDSGTTVFRFAFSDMFEKGALKIATVGL FISFCYSTVTSYLSVFAKSVDLSDISGYFFVCFAVTMMIARPFTGKLFDKVGPGIVIY PSILIFSVGLCMLSFTHSGLMLLLSGAVIGLGYGSIVPCMQTLAIQKSPAHRSGFATA TFFTFFDSGIAVGSYVFGLFVASAGFSAIYLTAGLFVLIALLLYTWSQKKPAEAEGKV SIAE*" /label="ywoG CDS" gene 3373810..3375000 /gene="ywoG" /locus_tag="BSU_36450" /old_locus_tag="BSU36450" /label="ywoG gene" CDS complement(3375091..3376497) /gene="ywoF" /locus_tag="BSU_36460" /old_locus_tag="BSU36460" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15266115, 16607952, 23504016; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative pectin lyase" /protein_id="NP_391527.1" /db_xref="EnsemblGenomes-Gn:BSU36460" /db_xref="EnsemblGenomes-Tr:CAB15663" /db_xref="GOA:P94576" /db_xref="InterPro:IPR006626" /db_xref="InterPro:IPR006633" /db_xref="InterPro:IPR011050" /db_xref="InterPro:IPR012334" /db_xref="SubtiList:BG12493" /db_xref="UniProtKB/Swiss-Prot:P94576" /translation="MRKWYFILLAGVLTSVILAFVYDKTKANEEGSGDYLYVSPNGSD QNEGTKEKPFRTLAHASEKAAAGTTVMIREGTYHETLDVKHSGTDGKPITFRNYENEN VVISGESVANAEYETPLIRIHDKHDIAISGLTIQDLSVSSEEATAIGIYVSGSSSHIA IKDNHIRGIKTTADEGNAHGIAVYGTGSMKDIRIEDNTVEKLTLGASEAVVLNGNIDG FTVAGNVVRNNNNIGIDLIGYEGTADKNDYVRNGVVENNTVYQNSTYGNPAYGDEYSA GGIYVDGGHDIEIKNNTVYDNDIGIEATSEHKGKYANAIQITDNKVYNNAYTGISIGG YDKKRGGTSNSLIARNIMYRNDTKGLYGGQLLLQYDTKNNTIEKNILTAGDSRLFIGN DFTENEGNTVNHNVYHKEADQDGIWMWKKKEYDSFSSYRKATKNDQQSIYADPMFRDE ASYDFSLDPDSPARPVIE*" /label="ywoF CDS" gene complement(3375091..3376497) /gene="ywoF" /locus_tag="BSU_36460" /old_locus_tag="BSU36460" /label="ywoF gene" downshifts complement(3375388) /Source="Nicolas_upshifts" /id="D1885" /incds=1 /nref=1 /ntot=78 /MaxReadThrough="5.28695" /MaxDrop="2.1962" /score="4.73902293" /energy="-22.3" /TU="U2857" /idTUdmin="U2857" /TUdmin="-924" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3376530..3376549) /Source="Nicolas_upshift_promotors" /id="U2857" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.756243756243756" /psig="0.997002997002997" /xcortree=2979 /SigmaFactorBS="gaataagatctatttagacggtatattttcatatttttgaaA TGGttttccataaatagAACATTTATAATGGTTTTAGaaatctattctaaaacgaaat g" /listShort="ywoF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3376548) /Source="Nicolas_upshifts" /id="U2857" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.756243756243756" /psig="0.997002997002997" /xcortree=2979 /SigmaFactorBS="gaataagatctatttagacggtatattttcatatttttgaaA TGGttttccataaatagAACATTTATAATGGTTTTAGaaatctattctaaaacgaaat g" /listShort="ywoF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3376564..3376567) /Source="Nicolas_upshift_promotors" /id="U2857" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.756243756243756" /psig="0.997002997002997" /xcortree=2979 /SigmaFactorBS="gaataagatctatttagacggtatattttcatatttttgaaA TGGttttccataaatagAACATTTATAATGGTTTTAGaaatctattctaaaacgaaat g" /listShort="ywoF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3376603..3378075) /gene="pucI" /locus_tag="BSU_36470" /old_locus_tag="BSU36470" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11344136, 12029039, 15849754, 16850406, 26967546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 12029039, 15849754, 16850406, 26967546; Product type t : transporter" /codon_start=1 /transl_table=11 /product="allantoin permease" /protein_id="NP_391528.1" /db_xref="EnsemblGenomes-Gn:BSU36470" /db_xref="EnsemblGenomes-Tr:CAB15664" /db_xref="GOA:P94575" /db_xref="InterPro:IPR001248" /db_xref="InterPro:IPR012681" /db_xref="SubtiList:BG12492" /db_xref="UniProtKB/Swiss-Prot:P94575" /translation="MKLKESQQQSNRLSNEDLVPLGQEKRTWKAMNFASIWMGCIHNI PTYATVGGLIAIGLSPWQVLAIIITASLILFGALALNGHAGTKYGLPFPVIIRASYGI YGANIPALLRAFTAIMWLGIQTFAGSTALNILLLNMWPGWGEIGGEWNILGIHLSGLL SFVFFWAIHLLVLHHGMESIKRFEVWAGPLVYLVFGGMVWWAVDIAGGLGPIYSQPGK FHTFSETFWPFAAGVTGIIGIWATLILNIPDFTRFAETQKEQIKGQFYGLPGTFALFA FASITVTSGSQVAFGEPIWDVVDILARFDNPYVIVLSVITLCIATISVNVAANIVSPA YDIANALPKYINFKRGSFITALLALFTVPWKLMESATSVYAFLGLIGGMLGPVAGVMM ADYFIIRKRELSVDDLYSETGRYVYWKGYNYRAFAATMLGALISLIGMYVPVLKSLYD ISWFVGVLISFLFYIVLMRVHPPASLAIETVEHAQVRQAE*" /label="pucI CDS" gene complement(3376603..3378075) /gene="pucI" /locus_tag="BSU_36470" /old_locus_tag="BSU36470" /label="pucI gene" CDS complement(3378256..3379614) /gene="ywoD" /locus_tag="BSU_36480" /old_locus_tag="BSU36480" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_391529.1" /db_xref="EnsemblGenomes-Gn:BSU36480" /db_xref="EnsemblGenomes-Tr:CAB15665" /db_xref="GOA:P94574" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12491" /db_xref="UniProtKB/Swiss-Prot:P94574" /translation="MLSKKSRAVFLTAVASGTMLNPLNSSMISLALHSIQHEFHLSFT TVSWLISSFYLASAVAQPVTGKLGDLIGRKRLFLFGLILVAVSAIGAPFAPTFMTLLV MRLFQSVGSSAIYPSGVGLIRNHIHERQASALAVLSIFASAMTALGPTAGGFLIVWGG WPAIFIVNLPFIILSFLLGLYMFPKDQKKGAGIKTIIRQLDILGIVLFAGGIIFLLSF LLSFSTSPHAVEGVLGLLLLCAFVWRELKTDKPFIDVRLFKTQRNLSAVYVQFILLNV FFYCLFFGLPSYFQDEMHLSVQTSGLFMLFMSGMSIVVSPLTGKWIDRSGVVKPIFAG ALLMTAGAVLLTIFFINVQTIGKGLILSLLGIGYGLGNVALQAAMLETSPSNMVGTTS GLFQTCRYLGSILSSVILGILFGKEITAAHFDMMGIIMIIAGGASLLMAVRFAALMKT AS*" /label="ywoD CDS" gene complement(3378256..3379614) /gene="ywoD" /locus_tag="BSU_36480" /old_locus_tag="BSU36480" /label="ywoD gene" downshifts complement(3378270) /Source="Nicolas_upshifts" /id="D1886" /incds=0 /nref=58 /ntot=198 /MaxReadThrough="1.44148" /MaxDrop="4.13092" /score="20.2036192" /energy="-12.8" /TU="NA" /idTUdmin="U2858" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3379614..3380183) /gene="ywoC" /locus_tag="BSU_36490" /old_locus_tag="BSU36490" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme of isochorismatase family" /protein_id="NP_391530.2" /db_xref="EnsemblGenomes-Gn:BSU36490" /db_xref="EnsemblGenomes-Tr:CAB15666" /db_xref="GOA:P94573" /db_xref="InterPro:IPR000868" /db_xref="InterPro:IPR016291" /db_xref="InterPro:IPR036380" /db_xref="SubtiList:BG12490" /db_xref="UniProtKB/Swiss-Prot:P94573" /translation="MMNTLNIDFQKTALVIIDLQKGIVPIDQSGQVVPNAKKLVDEFR KHNGFISFVNVAFHDGADALKPQTDEPAQGGSGEMPADWAEFVPEIGVQDGDYTVTKR QWGAFFGTDLDLQLRRRGIDTIVLCGIATNIGVESTAREAFQLGYQQIFITDAMSTFS DEEHEATLRFIFPRIGKSRTTEEFLEQVK*" /label="ywoC CDS" gene complement(3379614..3380183) /gene="ywoC" /locus_tag="BSU_36490" /old_locus_tag="BSU36490" /label="ywoC gene" promotor_-10 complement(3380202..3380213) /Source="Nicolas_upshift_promotors" /id="U2858" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=804 /SigmaFactorBS="ccttctgagaatttcacaagcatcataaaagaacttaggcag tgtgaAGAGTAAaatatgcaatgtgAGAAACACTAACagtatcaggaggagacgtatg a" /listShort="ywoC, ywoD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3380220) /Source="Nicolas_upshifts" /id="U2858" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=804 /SigmaFactorBS="ccttctgagaatttcacaagcatcataaaagaacttaggcag tgtgaAGAGTAAaatatgcaatgtgAGAAACACTAACagtatcaggaggagacgtatg a" /listShort="ywoC, ywoD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3380227..3380233) /Source="Nicolas_upshift_promotors" /id="U2858" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=804 /SigmaFactorBS="ccttctgagaatttcacaagcatcataaaagaacttaggcag tgtgaAGAGTAAaatatgcaatgtgAGAAACACTAACagtatcaggaggagacgtatg a" /listShort="ywoC, ywoD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3380290..3380457) /locus_tag="BSU_36499" /old_locus_tag="BSU36499" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:CCQ48605.1" /translation="MSYPALDGPPQIHGHFQAGTDRQQAGDEAMTPFMITVLAGLFVC TTCYYYIKEKS*" /label="hypothetical protein CDS" gene complement(3380290..3380457) /locus_tag="BSU_36499" /old_locus_tag="BSU36499" /pseudo /label="gene" CDS complement(3380367..3380831) /gene="ywoB" /locus_tag="BSU_36500" /old_locus_tag="BSU36500" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 21856850; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391531.1" /db_xref="EnsemblGenomes-Gn:BSU36500" /db_xref="EnsemblGenomes-Tr:CAB15667" /db_xref="GOA:P94572" /db_xref="InterPro:IPR020218" /db_xref="SubtiList:BG12489" /db_xref="UniProtKB/Swiss-Prot:P94572" /translation="MMNKGGRLRKAVRKSIPATFRLFLAFNFFVYGLAKVVIGQFGEV TPEIEAAAGKGFTIAWTFFGYSHVYELFIGFGEILAAVLLLIPRTAALGAVIFMPIIV NIVLINYCFDIGVQDLSTILMVMCLILLWMDRRKFMGIFRQEPIDSRQVMKR*" /label="ywoB CDS" gene complement(3380367..3380831) /gene="ywoB" /locus_tag="BSU_36500" /old_locus_tag="BSU36500" /label="ywoB gene" promotor_-10 complement(3380861..3380880) /Source="Nicolas_upshift_promotors" /id="U2859" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.736263736263736" /psig="0.999000999001" /xcortree=2195 /SigmaFactorBS="actattcatatgagctgaaaagggaATTGACATtaattagaa tactCTATACTGTATTAAGTGTACtacatcaaataatacactgagggggatgtatgat g" /listShort="ywoB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3380866) /Source="Nicolas_upshifts" /id="U2859" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.736263736263736" /psig="0.999000999001" /xcortree=2195 /SigmaFactorBS="actattcatatgagctgaaaagggaATTGACATtaattagaa tactCTATACTGTATTAAGTGTACtacatcaaataatacactgagggggatgtatgat g" /listShort="ywoB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3380894..3380901) /Source="Nicolas_upshift_promotors" /id="U2859" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.736263736263736" /psig="0.999000999001" /xcortree=2195 /SigmaFactorBS="actattcatatgagctgaaaagggaATTGACATtaattagaa tactCTATACTGTATTAAGTGTACtacatcaaataatacactgagggggatgtatgat g" /listShort="ywoB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3381032..3381035 /Source="Nicolas_upshift_promotors" /id="U2860" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.835164835164835" /psig="0.978021978021978" /xcortree=320 /SigmaFactorBS="acatttctcaaaaaccatgtcaggaaatcttacatgaaAATG ttttatcattctttTTTCTCTATAATGAAGAAATataataattgctttttattctgaa a" /listShort="amtB, glnK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3381050..3381069 /Source="Nicolas_upshift_promotors" /id="U2860" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.835164835164835" /psig="0.978021978021978" /xcortree=320 /SigmaFactorBS="acatttctcaaaaaccatgtcaggaaatcttacatgaaAATG ttttatcattctttTTTCTCTATAATGAAGAAATataataattgctttttattctgaa a" /listShort="amtB, glnK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3381054 /Source="Nicolas_upshifts" /id="U2860" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.835164835164835" /psig="0.978021978021978" /xcortree=320 /SigmaFactorBS="acatttctcaaaaaccatgtcaggaaatcttacatgaaAATG ttttatcattctttTTTCTCTATAATGAAGAAATataataattgctttttattctgaa a" /listShort="amtB, glnK" /GFF_Attribute="listLong" /label="upshifts" CDS 3381113..3382327 /gene="amtB" /locus_tag="BSU_36510" /old_locus_tag="BSU36510" /function="16.1: Circulate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14600241, 15849754, 16850406, 17001076, 21435182" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14600241, 15849754, 16850406, 17001076, 21435182; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ammonium transporter" /protein_id="NP_391532.1" /db_xref="EnsemblGenomes-Gn:BSU36510" /db_xref="EnsemblGenomes-Tr:CAB15668" /db_xref="GOA:Q07429" /db_xref="InterPro:IPR001905" /db_xref="InterPro:IPR018047" /db_xref="InterPro:IPR024041" /db_xref="InterPro:IPR029020" /db_xref="SubtiList:BG10869" /db_xref="UniProtKB/Swiss-Prot:Q07429" /translation="MQMGDTVFMFFCALLVWLMTPGLALFYGGMVKSKNVLSTAMHSF SSIAIVSIVWVLFGYTLAFAPGNSIIGGLEWAGLKGVGFDPGDYSDTIPHSLFMMFQM TFAVLTTAIISGAFAERMRFGAFLLFSVLWASLVYTPVAHWVWGGGWIGQLGALDFAG GNVVHISSGVAGLVLAIVLGKRKDGTASSPHNLIYTFLGGALIWFGWFGFNVGSALTL DGVAMYAFINTNTAAAAGIAGWILVEWIINKKPTMLGAVSGAIAGLVAITPAAGFVTP FASIIIGIIGGAVCFWGVFSLKKKFGYDDALDAFGLHGIGGTWGGIATGLFATTSVNS AGADGLFYGDASLIWKQIVAIAATYVFVFIVTFVIIKIVSLFLPLRATEEEESLGLDL TMHGEKAYQDSM*" /label="amtB CDS" gene 3381113..3382327 /gene="amtB" /locus_tag="BSU_36510" /old_locus_tag="BSU36510" /label="amtB gene" promotor_-10 complement(3381943..3381961) /Source="Nicolas_upshift_promotors" /id="U2861" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2846 /SigmaFactorBS="taagcgagaatactccccagaaACAAACAGctccgccgatga tGCCGATAATAATGGAAGCGaacggtgtgacaaatccggcagccggcgtaatggcgac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3381944) /Source="Nicolas_upshifts" /id="U2861" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2846 /SigmaFactorBS="taagcgagaatactccccagaaACAAACAGctccgccgatga tGCCGATAATAATGGAAGCGaacggtgtgacaaatccggcagccggcgtaatggcgac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3381975..3381982) /Source="Nicolas_upshift_promotors" /id="U2861" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2846 /SigmaFactorBS="taagcgagaatactccccagaaACAAACAGctccgccgatga tGCCGATAATAATGGAAGCGaacggtgtgacaaatccggcagccggcgtaatggcgac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3382193..3382199 /Source="Nicolas_upshift_promotors" /id="U2862" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.344655344655345" /psig="0.993006993006993" /xcortree=610 /SigmaFactorBS="tctggaaacaaatcgtcgccatcgccgccacttatgttTTTG TATttattgtcactttCGTTATTATTAAAATTGTAAgcctcttccttccccttcgcgc a" /listShort="glnK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3382213..3382232 /Source="Nicolas_upshift_promotors" /id="U2862" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.344655344655345" /psig="0.993006993006993" /xcortree=610 /SigmaFactorBS="tctggaaacaaatcgtcgccatcgccgccacttatgttTTTG TATttattgtcactttCGTTATTATTAAAATTGTAAgcctcttccttccccttcgcgc a" /listShort="glnK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3382215 /Source="Nicolas_upshifts" /id="U2862" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.344655344655345" /psig="0.993006993006993" /xcortree=610 /SigmaFactorBS="tctggaaacaaatcgtcgccatcgccgccacttatgttTTTG TATttattgtcactttCGTTATTATTAAAATTGTAAgcctcttccttccccttcgcgc a" /listShort="glnK" /GFF_Attribute="listLong" /label="upshifts" CDS 3382339..3382689 /gene="glnK" /locus_tag="BSU_36520" /old_locus_tag="BSU36520" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14600241, 17001076, 21435182, 23461034, 25691471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14600241, 17001076, 21435182, 23461034, 25691471; Product type r: regulator" /codon_start=1 /transl_table=11 /product="nitrogen-regulated PII-like regulator protein" /protein_id="NP_391533.1" /db_xref="EnsemblGenomes-Gn:BSU36520" /db_xref="EnsemblGenomes-Tr:CAB15669" /db_xref="GOA:Q07428" /db_xref="InterPro:IPR002187" /db_xref="InterPro:IPR011322" /db_xref="InterPro:IPR015867" /db_xref="InterPro:IPR017918" /db_xref="PDB:4R25" /db_xref="PDB:4RX6" /db_xref="SubtiList:BG10870" /db_xref="UniProtKB/Swiss-Prot:Q07428" /translation="MSGQMFKVEIVTRPANFEKLKQELGKIGVTSLTFSNVHGCGLQK AHTELYRGVKIESNVYERLKIEIVVSKVPVDQVTETAKRVLKTGSPGDGKIFVYEISN TINIRTGEEGPEAL*" /label="glnK CDS" gene 3382339..3382689 /gene="glnK" /locus_tag="BSU_36520" /old_locus_tag="BSU36520" /label="glnK gene" downshifts 3382682 /Source="Nicolas_upshifts" /id="D1887" /incds=0 /nref=179 /ntot=251 /MaxReadThrough="2.13701" /MaxDrop="8.63831" /score="25.582072" /energy="-12.5" /TU="NA" /idTUdmin="U2860" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 3382741..3382749 /Source="Nicolas_upshift_promotors" /id="U2863" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp=1 /psig=1 /xcortree=1773 /SigmaFactorBS="actccggatctctttttttgtgcacagaatcCCCCCAGAAac cgcgattcctcTTCGAATTCtcttcaagcgccgttatttcagacaatctctattttta t" /listShort="bcrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3382763..3382771 /Source="Nicolas_upshift_promotors" /id="U2863" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp=1 /psig=1 /xcortree=1773 /SigmaFactorBS="actccggatctctttttttgtgcacagaatcCCCCCAGAAac cgcgattcctcTTCGAATTCtcttcaagcgccgttatttcagacaatctctattttta t" /listShort="bcrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3382770 /Source="Nicolas_upshifts" /id="U2863" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp=1 /psig=1 /xcortree=1773 /SigmaFactorBS="actccggatctctttttttgtgcacagaatcCCCCCAGAAac cgcgattcctcTTCGAATTCtcttcaagcgccgttatttcagacaatctctattttta t" /listShort="bcrC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3382812..3382821 /Source="Nicolas_upshift_promotors" /id="U2864" /multdbtbs="SigM,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1653 /SigmaFactorBS="agcgccgttatttcagacaatctctatttttattTGAAACTT TTcatgagtaagatTAGTCTACTAAATATAaaaatgtaaaaggtgattatttgaacta c" /listShort="bcrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3382834..3382849 /Source="Nicolas_upshift_promotors" /id="U2864" /multdbtbs="SigM,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1653 /SigmaFactorBS="agcgccgttatttcagacaatctctatttttattTGAAACTT TTcatgagtaagatTAGTCTACTAAATATAaaaatgtaaaaggtgattatttgaacta c" /listShort="bcrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3382838 /Source="Nicolas_upshifts" /id="U2864" /multdbtbs="SigM,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1653 /SigmaFactorBS="agcgccgttatttcagacaatctctatttttattTGAAACTT TTcatgagtaagatTAGTCTACTAAATATAaaaatgtaaaaggtgattatttgaacta c" /listShort="bcrC" /GFF_Attribute="listLong" /label="upshifts" CDS 3382870..3383451 /gene="bcrC" /locus_tag="BSU_36530" /old_locus_tag="BSU36530" /EC_number="3.6.1.27" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12486040, 14612242, 15838020, 15849754, 15946938, 16850406, 27528508" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12486040, 14612242, 15838020, 15849754, 15946938, 16850406, 27528508; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="undecaprenyl pyrophosphate phosphatase (bacitracin resistance)" /protein_id="NP_391534.1" /db_xref="EnsemblGenomes-Gn:BSU36530" /db_xref="EnsemblGenomes-Tr:CAB15670" /db_xref="GOA:P94571" /db_xref="InterPro:IPR000326" /db_xref="InterPro:IPR033879" /db_xref="InterPro:IPR036938" /db_xref="SubtiList:BG12488" /db_xref="UniProtKB/Swiss-Prot:P94571" /translation="MNYEIFKAIHGLSHHNSVLDSIMVFITEYAIVAYALILLAIWLF GNTQSRKHVLYAGITGIAGLVINYLITLVYFEPRPFVAHTVHTLIPHAADASFPSDHT TGALAISIAMLFRNRKIGWPLVIFGLLTGFSRIWVGHHYPVDVLGSLVVAIIIGFLFF RFSDLLRPFVDLVVRIYEAIINKLTKKPTDQNF*" /label="bcrC CDS" gene 3382870..3383451 /gene="bcrC" /locus_tag="BSU_36530" /old_locus_tag="BSU36530" /label="bcrC gene" promotor_-10 complement(3382968..3382987) /Source="Nicolas_upshift_promotors" /id="U2865" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.793206793206793" /psig="0.793206793206793" /xcortree=1382 /SigmaFactorBS="ctgcgtatagcacatgttttctgctttgtGTGTTCCCAaaca gccagattgCCAATAGGATAAGGGCATAGgcgacaatggcatattccgtgatgaagac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3382978) /Source="Nicolas_upshifts" /id="U2865" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.793206793206793" /psig="0.793206793206793" /xcortree=1382 /SigmaFactorBS="ctgcgtatagcacatgttttctgctttgtGTGTTCCCAaaca gccagattgCCAATAGGATAAGGGCATAGgcgacaatggcatattccgtgatgaagac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3383001..3383009) /Source="Nicolas_upshift_promotors" /id="U2865" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.793206793206793" /psig="0.793206793206793" /xcortree=1382 /SigmaFactorBS="ctgcgtatagcacatgttttctgctttgtGTGTTCCCAaaca gccagattgCCAATAGGATAAGGGCATAGgcgacaatggcatattccgtgatgaagac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3383432 /Source="Nicolas_upshifts" /id="D1888" /incds=0 /nref=192 /ntot=251 /MaxReadThrough="2.1929" /MaxDrop="6.53316" /score="25.582072" /energy="-12.5" /TU="NA" /idTUdmin="U2863" /TUdmin=2 /isTUend="TRUE" /label="downshifts" CDS complement(3383492..3383914) /gene="ywnJ" /locus_tag="BSU_36540" /old_locus_tag="BSU36540" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14762009, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391535.1" /db_xref="EnsemblGenomes-Gn:BSU36540" /db_xref="EnsemblGenomes-Tr:CAB15671" /db_xref="GOA:P71045" /db_xref="InterPro:IPR006976" /db_xref="SubtiList:BG12487" /db_xref="UniProtKB/Swiss-Prot:P71045" /translation="MNRLLLAGWIFFILLSVCTESFSGMVVSQTVAFHFQPHPDLSQF LVMDFTELTVPEAFIQKIGHAFSFFVLTYLLWKQRGSIRSAAAGSFAFAFFTEVLQLF FSRNGCIRDVLIDAVGIGLFYGLYVLAKRRKQEMYEKY*" /label="ywnJ CDS" gene complement(3383492..3383914) /gene="ywnJ" /locus_tag="BSU_36540" /old_locus_tag="BSU36540" /label="ywnJ gene" downshifts complement(3383511) /Source="Nicolas_upshifts" /id="D1889" /incds=0 /nref=9 /ntot=75 /MaxReadThrough="0.80227" /MaxDrop="3.65224" /score="4.98901321" /energy="-13.6" /TU="NA" /idTUdmin="U2869" /TUdmin=215 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3383949..3383964) /Source="Nicolas_upshift_promotors" /id="U2866" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1654 /SigmaFactorBS="ttaatgaagaaaacgtctatccttgtgatgggcgtttttttc TGTTACTTTTtgctttgttttaCCGTCTATGTAGTTACatgtaggcacgtacgttata a" /listShort="ywnJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3383968) /Source="Nicolas_upshifts" /id="U2866" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1654 /SigmaFactorBS="ttaatgaagaaaacgtctatccttgtgatgggcgtttttttc TGTTACTTTTtgctttgttttaCCGTCTATGTAGTTACatgtaggcacgtacgttata a" /listShort="ywnJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3383977..3383986) /Source="Nicolas_upshift_promotors" /id="U2866" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1654 /SigmaFactorBS="ttaatgaagaaaacgtctatccttgtgatgggcgtttttttc TGTTACTTTTtgctttgttttaCCGTCTATGTAGTTACatgtaggcacgtacgttata a" /listShort="ywnJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3384025..3384876) /gene="spoIIQ" /locus_tag="BSU_36550" /old_locus_tag="BSU36550" /function="16.8: Protect" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16164552, 16959571, 17121846, 18077456, 21097616, 23859254, 26929302, 27381174, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16164552, 16959571, 17121846, 18077456, 21097616, 23859254, 26929302, 27381174, 28784753; Product type f: factor" /codon_start=1 /transl_table=11 /product="forespore protein required for alternative engulfment" /protein_id="NP_391536.1" /db_xref="EnsemblGenomes-Gn:BSU36550" /db_xref="EnsemblGenomes-Tr:CAB15672" /db_xref="GOA:P71044" /db_xref="InterPro:IPR011055" /db_xref="InterPro:IPR016047" /db_xref="PDB:3TUF" /db_xref="PDB:3UZ0" /db_xref="SubtiList:BG11978" /db_xref="UniProtKB/Swiss-Prot:P71044" /translation="MREEEKKTSQVKKLQQFFRKRWVFPAIYLVSAAVILTAVLWYQS VSNDEVKDQLADNGGNSAYDNNDDAVEVGKSMENVAMPVVDSENVSVVKKFYETDAAK EEKEAALVTYNNTYSLSKGIDLAEKDGKDFDVSASLSGTVVKAEKDPVLGYVVEVEHA DGLSTVYQSLSEVSVEQGDKVKQNQVIGKSGKNLYSEDSGNHVHFEIRKDGVAMNPLN FMDKPVSSIEKAATQETEESIQQSSEKKDGSTEKGTEEKSGEKKDDSTDKSGSKESST TEDTEQS*" /label="spoIIQ CDS" gene complement(3384025..3384876) /gene="spoIIQ" /locus_tag="BSU_36550" /old_locus_tag="BSU36550" /label="spoIIQ gene" downshifts complement(3384034) /Source="Nicolas_upshifts" /id="D1890" /incds=0 /nref=19 /ntot=51 /MaxReadThrough="3.592" /MaxDrop="5.16472" /score="11.9597238" /energy="-7.1" /TU="U2869" /idTUdmin="U2866" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" downshifts complement(3384276) /Source="Nicolas_upshifts" /id="D1891" /incds=1 /nref=4 /ntot=59 /MaxReadThrough="6.6416" /MaxDrop="3.0034" /score="11.9597238" /energy="-7.1" /TU="U2869" /idTUdmin="U2866" /TUdmin="-418" /isTUend="FALSE" /label="downshifts" promotor_-35 3384513..3384515 /Source="Nicolas_upshift_promotors" /id="U2867" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.578421578421578" /psig="0.999000999001" /xcortree=2749 /SigmaFactorBS="gagacatcgaaatcttttccgtctttctcagctaagtcaaTT CctttgcttaggctgtaCGTGTTATTATAGGTAACGAgtgctgcttctttctcttctt t" /listShort="S1406, S1407, ywnH, ywnG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3384532..3384551 /Source="Nicolas_upshift_promotors" /id="U2867" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.578421578421578" /psig="0.999000999001" /xcortree=2749 /SigmaFactorBS="gagacatcgaaatcttttccgtctttctcagctaagtcaaTT CctttgcttaggctgtaCGTGTTATTATAGGTAACGAgtgctgcttctttctcttctt t" /listShort="S1406, S1407, ywnH, ywnG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3384533..3384879 /Source="Nicolas_S_feature" /locus_tag="new_3760210_3760556" /HighExp="LBGstat, LBGtran, Cold, Sw, dia15, C30, G180, Lbexp, LBGexp, UNK1" /AntisenseName="spoIIQ" /AntisenseCor="-0.81767802234568998" /AntisenseRegPval="-65.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1406" upshifts 3384533 /Source="Nicolas_upshifts" /id="U2867" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.578421578421578" /psig="0.999000999001" /xcortree=2749 /SigmaFactorBS="gagacatcgaaatcttttccgtctttctcagctaagtcaaTT CctttgcttaggctgtaCGTGTTATTATAGGTAACGAgtgctgcttctttctcttctt t" /listShort="S1406, S1407, ywnH, ywnG" /GFF_Attribute="listLong" /label="upshifts" misc_feature 3384871..3384874 /Source="Nicolas_upshift_promotors" /id="U2868" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.27972027972028" /psig="0.121878121878122" /xcortree=579 /SigmaFactorBS="cgaaaaaactgctgaagttttttgacttgagaagttttcttt tcttcctcTCTCattgtttcatcacctcagcaacattctgaacacttttctgaaaata t" /listShort="S1407, ywnH, ywnG" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 3384881..3385016 /Source="Nicolas_S_feature" /locus_tag="new_3760558_3760693" /HighExp="LBGstat, S8, LBGtran, Sw, LoTm, BC, Cold, S7, C30, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.122, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1407" upshifts 3384881 /Source="Nicolas_upshifts" /id="U2868" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.27972027972028" /psig="0.121878121878122" /xcortree=579 /SigmaFactorBS="cgaaaaaactgctgaagttttttgacttgagaagttttcttt tcttcctcTCTCattgtttcatcacctcagcaacattctgaacacttttctgaaaata t" /listShort="S1407, ywnH, ywnG" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3384910) /Source="Nicolas_upshifts" /id="U2869" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.933066933066933" /psig="0.933066933066933" /xcortree=974 /SigmaFactorBS="tcagtctgtgcaaactacatctaaaaaagtttttttggatag gttGTATATATTTtcagaaaagtgttcagaatgttgctgaggtgatgaaacaatgaga g" /listShort="spoIIQ, ywnJ" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(3384916..3384925) /Source="Nicolas_upshift_promotors" /id="U2869" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.933066933066933" /psig="0.933066933066933" /xcortree=974 /SigmaFactorBS="tcagtctgtgcaaactacatctaaaaaagtttttttggatag gttGTATATATTTtcagaaaagtgttcagaatgttgctgaggtgatgaaacaatgaga g" /listShort="spoIIQ, ywnJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 3385017..3385508 /gene="ywnH" /locus_tag="BSU_36560" /old_locus_tag="BSU36560" /EC_number="2.3.1.183" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12793527, 16021622, 27694229; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aminoacid analogs (phosphinothricin) N-acetyltransferase" /protein_id="NP_391537.1" /db_xref="EnsemblGenomes-Gn:BSU36560" /db_xref="EnsemblGenomes-Tr:CAB15673" /db_xref="GOA:P71043" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="PDB:1VHS" /db_xref="SubtiList:BG12486" /db_xref="UniProtKB/Swiss-Prot:P71043" /translation="MTLRLAEHRDLEAVVAIYNSTIASRMVTADTEPVTPEDRMEWFS GHTESRPLYVAEDENGNVAAWISFETFYGRPAYNKTAEVSIYIDEACRGKGVGSYLLQ EALRIAPNLGIRSLMAFIFGHNKPSLKLFEKHGFAEWGLFPGIAEMDGKRYDLKILGR ELS*" /label="ywnH CDS" gene 3385017..3385508 /gene="ywnH" /locus_tag="BSU_36560" /old_locus_tag="BSU36560" /label="ywnH gene" promotor_-35 3385246..3385251 /Source="Nicolas_upshift_promotors" /id="U2870" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1178 /SigmaFactorBS="tttgaaacattttatggaaggccagcctATAATAaaacagcg gaagtcaGCATATACATTGACGAAGCatgccgcggcaaaggtgttggatcatatttgc t" /listShort="ywnG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3385267..3385285 /Source="Nicolas_upshift_promotors" /id="U2870" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1178 /SigmaFactorBS="tttgaaacattttatggaaggccagcctATAATAaaacagcg gaagtcaGCATATACATTGACGAAGCatgccgcggcaaaggtgttggatcatatttgc t" /listShort="ywnG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3385278 /Source="Nicolas_upshifts" /id="U2870" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1178 /SigmaFactorBS="tttgaaacattttatggaaggccagcctATAATAaaacagcg gaagtcaGCATATACATTGACGAAGCatgccgcggcaaaggtgttggatcatatttgc t" /listShort="ywnG" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3385369..3386277) /Source="Nicolas_S_feature" /locus_tag="new_3761046_3761954_c" /HighExp="H2O2, dia15, Diami, dia5, S8, Paraq, G180, G135, C30, G150" /AntisenseName="ywnG" /AntisenseCor="0.27407310266030799" /AntisenseRegPval="-5.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.946" /TUlongSig="NA" /TUlongPSig="NA" /label="S1408" CDS 3385505..3386023 /gene="ywnG" /locus_tag="BSU_36570" /old_locus_tag="BSU36570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22226636; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391538.1" /db_xref="EnsemblGenomes-Gn:BSU36570" /db_xref="EnsemblGenomes-Tr:CAB15674" /db_xref="GOA:P71042" /db_xref="InterPro:IPR035287" /db_xref="SubtiList:BG12485" /db_xref="UniProtKB/Swiss-Prot:P71042" /translation="MISLDKDENEIEHHNEENSLVEQETAPVGQESRQLSASAVKSLS DIAKWGKISGILLIIMGSLVTLSVLMTVIGAIPGVLLIISGVFLMRSAKAAAEAEGNL TGSAGESMLENYGTFIKMQLFYAASSIVTVLIGIIVAIFVLVVIGIAAFENTPSYDDP DSYYYEDDPVFE*" /label="ywnG CDS" gene 3385505..3386023 /gene="ywnG" /locus_tag="BSU_36570" /old_locus_tag="BSU36570" /label="ywnG gene" downshifts 3385828 /Source="Nicolas_upshifts" /id="D1892" /incds=1 /nref=1 /ntot=29 /MaxReadThrough="4.194" /MaxDrop="1.82458" /score="-3.39058903" /energy="-13.3" /TU="U2867,U2868,U2870" /idTUdmin="U2868" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" downshifts 3386026 /Source="Nicolas_upshifts" /id="D1893" /incds=0 /nref=3 /ntot=133 /MaxReadThrough="2.87136" /MaxDrop="2.9486" /score="-3.39058903" /energy="-13.3" /TU="U2867" /idTUdmin="U2870" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 3386182..3386313 /locus_tag="BSU_36575" /old_locus_tag="BSU36575" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514007.1" /translation="MNIKKTDEVGINPKPHFLFRVSACKKTHPDRLENLNNPGADLL* " /label="hypothetical protein CDS" gene 3386182..3386313 /locus_tag="BSU_36575" /old_locus_tag="BSU36575" /label="gene" CDS complement(3386310..3386744) /gene="ywnF" /locus_tag="BSU_36580" /old_locus_tag="BSU36580" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391539.1" /db_xref="EnsemblGenomes-Gn:BSU36580" /db_xref="EnsemblGenomes-Tr:CAB15675" /db_xref="GOA:P71041" /db_xref="InterPro:IPR020205" /db_xref="SubtiList:BG12484" /db_xref="UniProtKB/Swiss-Prot:P71041" /translation="MNFYRVEQMPGFIKTEMQKIQKAVQPFMKKTVIYRFLAIPLAAF SLFNLAAFLFHASADRESLISAGIFALLAALGLAFFKEAGYQHKQIQKTVHIYMLNRI KKSEILSEERKSSYARQIKEEPFAMRSFVEFLTEEDRRKKMY*" /label="ywnF CDS" gene complement(3386310..3386744) /gene="ywnF" /locus_tag="BSU_36580" /old_locus_tag="BSU36580" /label="ywnF gene" downshifts complement(3386322) /Source="Nicolas_upshifts" /id="D1894" /incds=0 /nref=174 /ntot=254 /MaxReadThrough="4.22489" /MaxDrop="5.35802" /score="21.5198482" /energy="-21.3" /TU="U2871" /idTUdmin="U2873" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3386793..3386812) /Source="Nicolas_upshift_promotors" /id="U2871" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.887112887112887" /psig="0.946053946053946" /xcortree=631 /SigmaFactorBS="attcttcgtgaaaaatacgggcagatTTCTTTAAaaccagct tgcaccTGCGTTAAAATAAACACATAtgataacgttcgtgaagcttgaaacatcaaat a" /listShort="ywnF, S1408" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3386800) /Source="Nicolas_upshifts" /id="U2871" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.887112887112887" /psig="0.946053946053946" /xcortree=631 /SigmaFactorBS="attcttcgtgaaaaatacgggcagatTTCTTTAAaaccagct tgcaccTGCGTTAAAATAAACACATAtgataacgttcgtgaagcttgaaacatcaaat a" /listShort="ywnF, S1408" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3386802..3387099) /Source="Nicolas_S_feature" /locus_tag="new_3762479_3762776_c" /HighExp="Etha, S6, S3, S4, S8, S5, S7, M9-stat, Sw, Salt" /AntisenseName="clsA" /AntisenseCor="-0.16109419145114601" /AntisenseRegPval="-2.1" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigEF" /TUshortPSig="0.99, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1409" promotor_-35 complement(3386827..3386834) /Source="Nicolas_upshift_promotors" /id="U2871" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.887112887112887" /psig="0.946053946053946" /xcortree=631 /SigmaFactorBS="attcttcgtgaaaaatacgggcagatTTCTTTAAaaccagct tgcaccTGCGTTAAAATAAACACATAtgataacgttcgtgaagcttgaaacatcaaat a" /listShort="ywnF, S1408" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3386873..3386877 /Source="Nicolas_upshift_promotors" /id="U2872" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=1840 /SigmaFactorBS="ttttcacgaagaatctggatcgccgcTCTTTattcttttaaa atgtgAGTGTTATAATTTGTAATGGgaatcagatcactgttattcatggaatactaat g" /listShort="S1410, clsA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3386894..3386913 /Source="Nicolas_upshift_promotors" /id="U2872" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=1840 /SigmaFactorBS="ttttcacgaagaatctggatcgccgcTCTTTattcttttaaa atgtgAGTGTTATAATTTGTAATGGgaatcagatcactgttattcatggaatactaat g" /listShort="S1410, clsA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3386906..3386986 /Source="Nicolas_S_feature" /locus_tag="new_3762583_3762663" /HighExp="LBGstat, Diami, dia15, G180, Oxctl, H2O2, T0.30H, S8, Paraq, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1410" upshifts 3386907 /Source="Nicolas_upshifts" /id="U2872" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=1840 /SigmaFactorBS="ttttcacgaagaatctggatcgccgcTCTTTattcttttaaa atgtgAGTGTTATAATTTGTAATGGgaatcagatcactgttattcatggaatactaat g" /listShort="S1410, clsA" /GFF_Attribute="listLong" /label="upshifts" CDS 3386987..3388435 /gene="clsA" /locus_tag="BSU_36590" /old_locus_tag="BSU36590" /EC_number="2.7.8.-" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:14973018, 16755131, 18820022, 26708983" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14973018, 16755131, 18820022, 26708983; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cardiolipin synthase (major)" /protein_id="NP_391540.1" /db_xref="EnsemblGenomes-Gn:BSU36590" /db_xref="EnsemblGenomes-Tr:CAB15676" /db_xref="GOA:P71040" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR001736" /db_xref="InterPro:IPR022924" /db_xref="InterPro:IPR025202" /db_xref="InterPro:IPR027379" /db_xref="InterPro:IPR030874" /db_xref="SubtiList:BG12483" /db_xref="UniProtKB/Swiss-Prot:P71040" /translation="MSISSILLSLFFILNILLAIIVIFKERRDASASWAWLLVLFFIP VLGFILYLLFGHNLRRKHLFQWEDRKKIGIERLLKHQLEDLETKQFQFNNRATFDNKD LIYMLIMNNHAVFTEDNSVDVITDGRDKFQRLLSDISKAKDHIHLQYYIYKGDELGKK LRDALIQKAKEGVQVRVLYDELGSRTLRKKFFKELREAGGHVEVFFPSKLRPINLRLN YRNHRKLVIIDGMTGYVGGFNVGDEYLGLNPKFGYWRDTHIRLQGTAVHAIQTRFILD WNQASHHHTLTYIPNHFPDYGPKGNVGMQIVTSGPDSEWEQIKNGYIKMISNAKRSIL IQTPYFIPDASLLDALRIACLSGIDVNIMIPNKPDHAFVYWATLSYIGDLLKAGATVY IYDNGFIHAKTIVVDDEIASVGTANIDVRSFRLNFEVNAFIYDITIAKKLVSTFKEDL LVSRKFTYEEYLQRPLWIRIKESVSRLLSPIL*" /label="clsA CDS" gene 3386987..3388435 /gene="clsA" /locus_tag="BSU_36590" /old_locus_tag="BSU36590" /label="clsA gene" upshifts complement(3387099) /Source="Nicolas_upshifts" /id="U2873" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=743 /SigmaFactorBS="agattatggccgaataataAGTATAAaataaagcctaaaacG GGAATAAAGAAAAGAACAagcagccacgcccaagatgcactggcatcgcgccgttctt t" /listShort="S1409, ywnF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3387100..3387118) /Source="Nicolas_upshift_promotors" /id="U2873" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=743 /SigmaFactorBS="agattatggccgaataataAGTATAAaataaagcctaaaacG GGAATAAAGAAAAGAACAagcagccacgcccaagatgcactggcatcgcgccgttctt t" /listShort="S1409, ywnF" /GFF_Attribute="listLong" /label="promotor_-10" S_feature complement(3387101..3387444) /Source="Nicolas_S_feature" /locus_tag="new_3762778_3763121_c" /HighExp="S6, S8, S4, S5, S7, S3, T5.0H, M9-stat, C30, T4.0H" /AntisenseName="clsA" /AntisenseCor="3.3648966966722899E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1411" promotor_-35 complement(3387134..3387140) /Source="Nicolas_upshift_promotors" /id="U2873" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=743 /SigmaFactorBS="agattatggccgaataataAGTATAAaataaagcctaaaacG GGAATAAAGAAAAGAACAagcagccacgcccaagatgcactggcatcgcgccgttctt t" /listShort="S1409, ywnF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3387422..3387440) /Source="Nicolas_upshift_promotors" /id="U2874" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1084 /SigmaFactorBS="acaccttctttcgccttttggatgagagcgtcccgcaatttt tTGCCTAattcatcgcctttatAAATATAATACTGTAAATGgatatgatccttagcct t" /listShort="S1411, S1409, ywnF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3387444) /Source="Nicolas_upshifts" /id="U2874" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1084 /SigmaFactorBS="acaccttctttcgccttttggatgagagcgtcccgcaatttt tTGCCTAattcatcgcctttatAAATATAATACTGTAAATGgatatgatccttagcct t" /listShort="S1411, S1409, ywnF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3387456..3387461) /Source="Nicolas_upshift_promotors" /id="U2874" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1084 /SigmaFactorBS="acaccttctttcgccttttggatgagagcgtcccgcaatttt tTGCCTAattcatcgcctttatAAATATAATACTGTAAATGgatatgatccttagcct t" /listShort="S1411, S1409, ywnF" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3388424 /Source="Nicolas_upshifts" /id="D1895" /incds=0 /nref=6 /ntot=214 /MaxReadThrough="0.7051" /MaxDrop="4.44298" /score="26.7449315" /energy="-19.5" /TU="NA" /idTUdmin="U2872" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3388456..3389229) /gene="mta" /locus_tag="BSU_36600" /old_locus_tag="BSU36600" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10200972, 11581256, 18502870" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10200972, 11581256, 18502870; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator regulating efflux transporters synthesis (Fur-independent bacillibactin export)" /protein_id="NP_391541.1" /db_xref="EnsemblGenomes-Gn:BSU36600" /db_xref="EnsemblGenomes-Tr:CAB15677" /db_xref="GOA:P71039" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="InterPro:IPR012925" /db_xref="InterPro:IPR036244" /db_xref="PDB:1JBG" /db_xref="PDB:1R8D" /db_xref="SubtiList:BG12482" /db_xref="UniProtKB/Swiss-Prot:P71039" /translation="MKYQVKQVAEISGVSIRTLHHYDNIELLNPSALTDAGYRLYSDA DLERLQQILFFKEIGFRLDEIKEMLDHPNFDRKAALQSQKEILMKKKQRMDEMIQTID RTLLSVDGGETMNKRDLFAGLSMKDIEEHQQTYADEVRKLYGKEIAEETEKRTSAYSA DDWRTIMAEFDSIYRRIAARMKHGPDDAEIQAAVGAFRDHICQYHYDCTLDIFRGLGE VYITDERFTDSINQYGEGLAAFLREAIIIYCDHQENPRP*" /label="mta CDS" gene complement(3388456..3389229) /gene="mta" /locus_tag="BSU_36600" /old_locus_tag="BSU36600" /label="mta gene" downshifts complement(3388478) /Source="Nicolas_upshifts" /id="D1896" /incds=0 /nref=1 /ntot=54 /MaxReadThrough="0.46006" /MaxDrop="2.97389" /score="11.4339746" /energy="-19.5" /TU="NA" /idTUdmin="U2876" /TUdmin=1342 /isTUend="FALSE" /label="downshifts" promotor_-35 3389304..3389307 /Source="Nicolas_upshift_promotors" /id="U2875" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.85914085914086" /psig="0.982017982017982" /xcortree=2618 /SigmaFactorBS="caacgttagggtcaatccccaaaatgttattttctatATACa aaacttctcacaaaTAGTGTATAAAAGAAAAGTGagtatttttttgtaaaggggagcc a" /listShort="ywnC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3389323..3389342 /Source="Nicolas_upshift_promotors" /id="U2875" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.85914085914086" /psig="0.982017982017982" /xcortree=2618 /SigmaFactorBS="caacgttagggtcaatccccaaaatgttattttctatATACa aaacttctcacaaaTAGTGTATAAAAGAAAAGTGagtatttttttgtaaaggggagcc a" /listShort="ywnC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3389327 /Source="Nicolas_upshifts" /id="U2875" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.85914085914086" /psig="0.982017982017982" /xcortree=2618 /SigmaFactorBS="caacgttagggtcaatccccaaaatgttattttctatATACa aaacttctcacaaaTAGTGTATAAAAGAAAAGTGagtatttttttgtaaaggggagcc a" /listShort="ywnC" /GFF_Attribute="listLong" /label="upshifts" CDS 3389374..3389757 /gene="ywnC" /locus_tag="BSU_36610" /old_locus_tag="BSU36610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391542.1" /db_xref="EnsemblGenomes-Gn:BSU36610" /db_xref="EnsemblGenomes-Tr:CAB15678" /db_xref="GOA:P71038" /db_xref="InterPro:IPR035287" /db_xref="SubtiList:BG12481" /db_xref="UniProtKB/Swiss-Prot:P71038" /translation="MNPETMNKTLISISKWGKATGILFIIMGAITALSGAFFFLIGAV PGVLQIISGIFLMRSAREAGQMAEHNSGQSEDLMLENYAKFVKMQGIYLIVSIAVSIL AIIAFFIFLMLGIADGLFSDTYSTY*" /label="ywnC CDS" gene 3389374..3389757 /gene="ywnC" /locus_tag="BSU_36610" /old_locus_tag="BSU36610" /label="ywnC gene" downshifts 3389744 /Source="Nicolas_upshifts" /id="D1897" /incds=0 /nref=60 /ntot=180 /MaxReadThrough="1.0319" /MaxDrop="4.45212" /score="35.5991488" /energy="-11.4" /TU="NA" /idTUdmin="U2875" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3389792..3390433) /gene="ywnB" /locus_tag="BSU_36620" /old_locus_tag="BSU36620" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391543.1" /db_xref="EnsemblGenomes-Gn:BSU36620" /db_xref="EnsemblGenomes-Tr:CAB15679" /db_xref="InterPro:IPR016040" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12480" /db_xref="UniProtKB/Swiss-Prot:P71037" /translation="MKIGIIGASGKAGNEILKEAKKRGHEVTAIVRNASKVQEQDVAI LEKDVFELTAEDIKPFDAVVNAFGAAPGQEHLHVEAGRALISILKDAKHTRLLVVGGA GSLFVDEAKTTRLMDTPEFPKEYLPTASNQGENLKDLQQTDSISWTFLSPAAFFDPAG KRTGSYQKGKDNVIVNAKGDSYISYADYAIAVLDELEHPEHKNERFTVVSEAE*" /label="ywnB CDS" gene complement(3389792..3390433) /gene="ywnB" /locus_tag="BSU_36620" /old_locus_tag="BSU36620" /label="ywnB gene" downshifts complement(3389842) /Source="Nicolas_upshifts" /id="D1898" /incds=0 /nref=20 /ntot=170 /MaxReadThrough="3.62026" /MaxDrop="4.98934" /score="21.1363072" /energy="-11.4" /TU="U2876" /idTUdmin="U2876" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(3390501..3390902) /gene="ywnA" /locus_tag="BSU_36630" /old_locus_tag="BSU36630" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_391544.1" /db_xref="EnsemblGenomes-Gn:BSU36630" /db_xref="EnsemblGenomes-Tr:CAB15680" /db_xref="GOA:P71036" /db_xref="InterPro:IPR000944" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:1XD7" /db_xref="SubtiList:BG12479" /db_xref="UniProtKB/Swiss-Prot:P71036" /translation="MINSRLAVAIHILSLISMDEKTSSEIIADSVNTNPVVVRRMISL LKKADILTSRAGVPGASLKKDPADISLLEVYRAVQKQEELFAVHENPNPKCPVGKKIQ NALDETFESVQRAMENELASKSLKDVMNHLF*" /label="ywnA CDS" gene complement(3390501..3390902) /gene="ywnA" /locus_tag="BSU_36630" /old_locus_tag="BSU36630" /label="ywnA gene" promotor_-10 complement(3390951..3390970) /Source="Nicolas_upshift_promotors" /id="U2876" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.385614385614386" /psig="0.993006993006993" /xcortree=1847 /SigmaFactorBS="gtgcatccggccgttctattgactaaaaacgGTGCACaaaac ccatgtattTAGTGTATATTAGATGTTGAcaaacgaatcaaatgtaactattatagtt a" /listShort="ywnA, ywnB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3390961) /Source="Nicolas_upshifts" /id="U2876" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.385614385614386" /psig="0.993006993006993" /xcortree=1847 /SigmaFactorBS="gtgcatccggccgttctattgactaaaaacgGTGCACaaaac ccatgtattTAGTGTATATTAGATGTTGAcaaacgaatcaaatgtaactattatagtt a" /listShort="ywnA, ywnB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3390963..3391036) /Source="Nicolas_S_feature" /locus_tag="new_3766640_3766713_c" /HighExp="BT, Etha, S1, B60, LoTm, B36, S2, Glucon, Sw, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.18507799999999999" /TUshortSig="Sig-" /TUshortPSig="0.106" /TUlongSig="SigH, SigA, SigB, SigB" /TUlongPSig="1, 0.993, 1, 0.995" /label="S1412" promotor_-35 complement(3390985..3390990) /Source="Nicolas_upshift_promotors" /id="U2876" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.385614385614386" /psig="0.993006993006993" /xcortree=1847 /SigmaFactorBS="gtgcatccggccgttctattgactaaaaacgGTGCACaaaac ccatgtattTAGTGTATATTAGATGTTGAcaaacgaatcaaatgtaactattatagtt a" /listShort="ywnA, ywnB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3391037..3392746) /gene="ureC" /locus_tag="BSU_36640" /old_locus_tag="BSU36640" /EC_number="3.5.1.5" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9287005, 12401490, 16199586" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9287005, 12401490, 16199586; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="urease (alpha subunit)" /protein_id="NP_391545.1" /db_xref="EnsemblGenomes-Gn:BSU36640" /db_xref="EnsemblGenomes-Tr:CAB15681" /db_xref="GOA:P77837" /db_xref="InterPro:IPR005848" /db_xref="InterPro:IPR006680" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR011612" /db_xref="InterPro:IPR017950" /db_xref="InterPro:IPR017951" /db_xref="InterPro:IPR029754" /db_xref="InterPro:IPR032466" /db_xref="SubtiList:BG11983" /db_xref="UniProtKB/Swiss-Prot:P77837" /translation="MKMSREEYAELFGPTTGDKIRLGDTDLWIEVEKDFTVYGEEMIF GGGKTIRDGMGQNGRITGKDGALDLVITNVVLLDYTGIVKADVGVKDGRIVGVGKSGN PDIMDGVDPHMVIGAGTEVISGEGKILTAGGVDTHIHFICPQQMEVALSSGVTTLLGG GTGPATGSKATTCTSGAWYMARMLEAAEEFPINVGFLGKGNASDKAPLIEQVEAGAIG LKLHEDWGTTPSAIKTCMEVVDEADIQVAIHTDTINEAGFLENTLDAIGDRVIHTYHI EGAGGGHAPDIMKLASYANILPSSTTPTIPYTVNTMDEHLDMMMVCHHLDAKVPEDVA FSHSRIRAATIAAEDILHDIGAISMTSSDSQAMGRVGEVIIRTWQVADKMKKQRGALA GENGNDNVRAKRYIAKYTINPAITHGLSHEVGSVEKGKLADLVLWDPVFFGVKPELVL KGGMIARAQMGDPNASIPTPEPVFMRQMYASYGKANRSTSITFMSQASIERGVAESLG LEKRISPVKNIRKLSKLDMKLNSALPKIEIDPKTYQVFADGEELSCQPVDYVPLGQRY FLF*" /label="ureC CDS" gene complement(3391037..3392746) /gene="ureC" /locus_tag="BSU_36640" /old_locus_tag="BSU36640" /label="ureC gene" CDS complement(3392743..3393117) /gene="ureB" /locus_tag="BSU_36650" /old_locus_tag="BSU36650" /EC_number="3.5.1.5" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9287005, 12401490, 16199586" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9287005, 12401490, 16199586; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="urease (beta subunit)" /protein_id="NP_391546.1" /db_xref="EnsemblGenomes-Gn:BSU36650" /db_xref="EnsemblGenomes-Tr:CAB15682" /db_xref="GOA:P71035" /db_xref="InterPro:IPR002019" /db_xref="InterPro:IPR036461" /db_xref="SubtiList:BG11982" /db_xref="UniProtKB/Swiss-Prot:P71035" /translation="MKPGAFQIAEGTITINEGREIREVTVKNTGSRSIQVGSHFHFAE ANGALLFDRELAIGMRLDVPSGTSVRFEPGEQKTVSLVEIRGRKTIRGLNGMADTFID ERGKEKTLANLKQAGWMEGVIR*" /label="ureB CDS" gene complement(3392743..3393117) /gene="ureB" /locus_tag="BSU_36650" /old_locus_tag="BSU36650" /label="ureB gene" CDS complement(3393114..3393431) /gene="ureA" /locus_tag="BSU_36660" /old_locus_tag="BSU36660" /EC_number="3.5.1.5" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9287005, 12401490, 16199586" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9287005, 12401490, 16199586; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="urease (gamma subunit)" /protein_id="NP_391547.1" /db_xref="EnsemblGenomes-Gn:BSU36660" /db_xref="EnsemblGenomes-Tr:CAB15683" /db_xref="GOA:P75030" /db_xref="InterPro:IPR002026" /db_xref="InterPro:IPR012010" /db_xref="InterPro:IPR036463" /db_xref="SubtiList:BG11981" /db_xref="UniProtKB/Swiss-Prot:P75030" /translation="MKLTPVEQEKLLIFAAGELAKQRKARGVLLNYPEAAAYITCFIM EGARDGKGVAELMEAGRHVLTEKDVMEGVPEMLDSIQVEATFPDGVKLVTVHQPISAE VKS*" /label="ureA CDS" gene complement(3393114..3393431) /gene="ureA" /locus_tag="BSU_36660" /old_locus_tag="BSU36660" /label="ureA gene" S_feature complement(3393432..3393516) /Source="Nicolas_S_feature" /locus_tag="new_3769109_3769193_c" /HighExp="BT, B60, B36, S1, Etha, LoTm, M9-stat, S2, T0.30H, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigH, SigB" /TUshortPSig="0.106, 1, 1" /TUlongSig="SigA, SigB" /TUlongPSig="0.993, 0.995" /label="S1413" upshifts complement(3393516) /Source="Nicolas_upshifts" /id="U2877" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.525474525474525" /psig="0.105894105894106" /xcortree=402 /SigmaFactorBS="gatgaagaaacggcatgccgctttgaaaggcatcttaccgta tgaCCCCCATTCTCGAAgaaagggaggtgatgtcccgcctgactgttccgcaaattcg t" /listShort="S1413, ureA, ureB, ureC, S1412, ywnA" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(3393518..3393531) /Source="Nicolas_upshift_promotors" /id="U2877" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.525474525474525" /psig="0.105894105894106" /xcortree=402 /SigmaFactorBS="gatgaagaaacggcatgccgctttgaaaggcatcttaccgta tgaCCCCCATTCTCGAAgaaagggaggtgatgtcccgcctgactgttccgcaaattcg t" /listShort="S1413, ureA, ureB, ureC, S1412, ywnA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature complement(3393518..3393611) /Source="Nicolas_S_feature" /locus_tag="new_3769195_3769288_c" /HighExp="BT, Etha, B60, S1, B36, BC, S2, LoTm, T3.0H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.30781199999999997" /TUshortSig="SigH, SigB" /TUshortPSig="1, 1" /TUlongSig="SigA, SigB" /TUlongPSig="0.993, 0.995" /label="S1414" CDS complement(3393612..3393776) /gene="ywzE" /locus_tag="BSU_36668" /old_locus_tag="BSU36668" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (putative phage interference protein)" /protein_id="YP_009514008.1" /translation="MVNLKNILLNKQLEGIQILIVELVRQVIIEISRKKDICYLSRAQ SGKRVNLIFP*" /label="ywzE CDS" gene complement(3393612..3393776) /gene="ywzE" /locus_tag="BSU_36668" /old_locus_tag="BSU36668" /label="ywzE gene" promotor_-10 complement(3393699..3393717) /Source="Nicolas_upshift_promotors" /id="U2878" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=403 /SigmaFactorBS="aaatctgaaaaatattttacttaataaacaattgGAAGGAAT TcagattttaatTGTCGAACTAGTCAGACAAgttattatagaaatttccagaaaaaaa g" /listShort="S1414, S1413, ureA, ureB, ureC" /listLong="S1412, ywnA" /label="promotor_-10" upshifts complement(3393711) /Source="Nicolas_upshifts" /id="U2878" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=403 /SigmaFactorBS="aaatctgaaaaatattttacttaataaacaattgGAAGGAAT TcagattttaatTGTCGAACTAGTCAGACAAgttattatagaaatttccagaaaaaaa g" /listShort="S1414, S1413, ureA, ureB, ureC" /listLong="S1412, ywnA" /label="upshifts" promotor_-35 complement(3393729..3393737) /Source="Nicolas_upshift_promotors" /id="U2878" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=403 /SigmaFactorBS="aaatctgaaaaatattttacttaataaacaattgGAAGGAAT TcagattttaatTGTCGAACTAGTCAGACAAgttattatagaaatttccagaaaaaaa g" /listShort="S1414, S1413, ureA, ureB, ureC" /listLong="S1412, ywnA" /label="promotor_-35" S_feature complement(3393777..3393948) /Source="Nicolas_S_feature" /locus_tag="new_3769454_3769625_c" /HighExp="Etha, BT, S1, GM-0.2, GM-0.1, Salt, GM 5, T-5.40H, MG 60, MG 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="0.993, 1" /TUlongSig="SigB" /TUlongPSig="0.995" /label="S1415" CDS complement(3393949..3394131) /gene="ywzF" /locus_tag="BSU_36669" /old_locus_tag="BSU36669" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /db_xref="PSEUDO:CAX52705.1" /translation="MKAGILHSLRGTVAISEVTVHDAELMAIVGFSVSWRSAPQTGLH AMLPVAEQNNGLPSGM*" /label="ywzF CDS" gene complement(3393949..3394131) /gene="ywzF" /locus_tag="BSU_36669" /old_locus_tag="BSU36669" /pseudo /label="ywzF gene" S_feature complement(3394132..3394278) /Source="Nicolas_S_feature" /locus_tag="new_3769809_3769955_c" /HighExp="Etha, BT, S1, Salt, GM-0.2, GM-0.1, M9-stat, GM 5, GM 45, UNK1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.15897800000000001" /TUshortSig="SigA, SigB" /TUshortPSig="0.993, 1" /TUlongSig="SigB" /TUlongPSig="0.995" /label="S1416" promotor_-10 complement(3394266..3394285) /Source="Nicolas_upshift_promotors" /id="U2879" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.722277722277722" /psig="0.993006993006993" /xcortree=2881 /SigmaFactorBS="tttggtcaaggtaactaaattttttaaatatTCTTTGAAtta ataggcctcttCTATATAATGATGACATAAGttgtaaacttttataacatcatttgaa g" /listShort="S1416, ywzF, S1415" /listLong="ywzE, S1414, S1413, ureA, ureB, ureC, S1412, ywnA" /label="promotor_-10" upshifts complement(3394278) /Source="Nicolas_upshifts" /id="U2879" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.722277722277722" /psig="0.993006993006993" /xcortree=2881 /SigmaFactorBS="tttggtcaaggtaactaaattttttaaatatTCTTTGAAtta ataggcctcttCTATATAATGATGACATAAGttgtaaacttttataacatcatttgaa g" /listShort="S1416, ywzF, S1415" /listLong="ywzE, S1414, S1413, ureA, ureB, ureC, S1412, ywnA" /label="upshifts" S_feature complement(3394280..3394394) /Source="Nicolas_S_feature" /locus_tag="new_3769957_3770070_c" /HighExp="Etha, Salt, M9-stat, S8, B60, B36, Sw, Gly, LoTm, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="SigB" /TUlongPSig="0.995" /label="S1417" promotor_-35 complement(3394300..3394307) /Source="Nicolas_upshift_promotors" /id="U2879" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.722277722277722" /psig="0.993006993006993" /xcortree=2881 /SigmaFactorBS="tttggtcaaggtaactaaattttttaaatatTCTTTGAAtta ataggcctcttCTATATAATGATGACATAAGttgtaaacttttataacatcatttgaa g" /listShort="S1416, ywzF, S1415" /listLong="ywzE, S1414, S1413, ureA, ureB, ureC, S1412, ywnA" /label="promotor_-35" Polymorphism join(3394381,3394383) /Source="geneious" /ID="SNP_BsDelta6_3770059_3770058" /Polymorphism_Type="Insertion (tandem repeat)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=0 /Amino_Acid_Change /CDS_Position /Change="(A)8 -> (A)9" /Codon_Change /Coverage=64 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides /Variant_Nucleotides="A" /Variant_P_Value="2.1e-197" /Variant_Raw_Frequency=61 /comment="-" /modified_by="User" / /label="Polymorphism_Delta6" upshifts 3394408 /Source="Nicolas_upshifts" /id="U2880" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.702297702297702" /psig="0.010989010989011" /xcortree=123 /SigmaFactorBS="tttttttgttatatttattcacatcagaaaaagcgaaaaaaa agacaagaaacatttcgtttcCTGCCtcttccgtacgattaatctttatctgaaaatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 3394411..3394415 /Source="Nicolas_upshift_promotors" /id="U2880" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.702297702297702" /psig="0.010989010989011" /xcortree=123 /SigmaFactorBS="tttttttgttatatttattcacatcagaaaaagcgaaaaaaa agacaagaaacatttcgtttcCTGCCtcttccgtacgattaatctttatctgaaaatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(3394428..3394616) /gene="csbD" /locus_tag="BSU_36670" /old_locus_tag="BSU36670" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10376822, 11988534" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10376822, 11988534; Product type f: factor" /codon_start=1 /transl_table=11 /product="stress response protein" /protein_id="NP_391548.1" /db_xref="EnsemblGenomes-Gn:BSU36670" /db_xref="EnsemblGenomes-Tr:CAB15684" /db_xref="InterPro:IPR008462" /db_xref="InterPro:IPR036629" /db_xref="SubtiList:BG12478" /db_xref="UniProtKB/Swiss-Prot:P70964" /translation="MGNDSVKDKMKGGFNKAKGEVKDKVGDMADRTDMQAEGKKDKAK GEIQKDIGKAKDKFSDKD*" /label="csbD CDS" gene complement(3394428..3394616) /gene="csbD" /locus_tag="BSU_36670" /old_locus_tag="BSU36670" /label="csbD gene" downshifts complement(3394439) /Source="Nicolas_upshifts" /id="D1899" /incds=0 /nref=69 /ntot=139 /MaxReadThrough="6.39376" /MaxDrop="6.75256" /score="21.8463823" /energy="-10.2" /TU="U2881" /idTUdmin="U2882" /TUdmin=221 /isTUend="FALSE" /label="downshifts" downshifts 3394606 /Source="Nicolas_upshifts" /id="D1900" /incds=0 /nref=15 /ntot=36 /MaxReadThrough="0.59322" /MaxDrop="5.27268" /score="-5.47050177" /energy="-8.1" /TU="NA" /idTUdmin="U2880" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3394642..3394660) /Source="Nicolas_upshift_promotors" /id="U2881" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=222 /SigmaFactorBS="agagcgctacgaaatcgataaataacattagaaTGTTTATtg cctctcagatcGGGAAGTTAACAAGTACACacataattgagaggggagaattaacatg g" /listShort="csbD, S1417, S1416, ywzF, S1415, ywzE, S1414, S1413, ureA, ureB" /listLong="ureC, S1412, ywnA" /label="promotor_-10" upshifts complement(3394653) /Source="Nicolas_upshifts" /id="U2881" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=222 /SigmaFactorBS="agagcgctacgaaatcgataaataacattagaaTGTTTATtg cctctcagatcGGGAAGTTAACAAGTACACacataattgagaggggagaattaacatg g" /listShort="csbD, S1417, S1416, ywzF, S1415, ywzE, S1414, S1413, ureA, ureB" /listLong="ureC, S1412, ywnA" /label="upshifts" promotor_-35 complement(3394674..3394680) /Source="Nicolas_upshift_promotors" /id="U2881" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=222 /SigmaFactorBS="agagcgctacgaaatcgataaataacattagaaTGTTTATtg cctctcagatcGGGAAGTTAACAAGTACACacataattgagaggggagaattaacatg g" /listShort="csbD, S1417, S1416, ywzF, S1415, ywzE, S1414, S1413, ureA, ureB" /listLong="ureC, S1412, ywnA" /label="promotor_-35" CDS complement(3394689..3395189) /gene="ywmF" /locus_tag="BSU_36680" /old_locus_tag="BSU36680" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_391549.2" /db_xref="EnsemblGenomes-Gn:BSU36680" /db_xref="EnsemblGenomes-Tr:CAB15685" /db_xref="GOA:P70963" /db_xref="SubtiList:BG12477" /db_xref="UniProtKB/Swiss-Prot:P70963" /translation="MHVRGNSMFGFNDMVKFLWSFLIVLPLVQIIHVSGHSFMAFIFG GKGSLDIGMGKTLLKIGPIRFRTIYFIDSFCRYGELKIDNRFSNALVYAGGCLFNLIT IFAINLLIIHSVLKPNVFFYQFVYFSTYYVFFALLPVRYSEKKSSDGLAIYKVLRYGE RYEIDK*" /label="ywmF CDS" gene complement(3394689..3395189) /gene="ywmF" /locus_tag="BSU_36680" /old_locus_tag="BSU36680" /label="ywmF gene" promotor_-10 complement(3395225..3395244) /Source="Nicolas_upshift_promotors" /id="U2882" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=97 /SigmaFactorBS="tttatgcaaaaaaaggggagcatcggaaCGTTTATttccggg gagaacAGGAAAAATCGCTACAGCACtgttttttgaacaaaagccgttttgggatgca g" /listShort="ywmF" /listLong="csbD, S1417, S1416, ywzF, S1415, ywzE, S1414, S1413, ureA, ureB, ureC, S1412, ywnA" /label="promotor_-10" upshifts complement(3395232) /Source="Nicolas_upshifts" /id="U2882" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=97 /SigmaFactorBS="tttatgcaaaaaaaggggagcatcggaaCGTTTATttccggg gagaacAGGAAAAATCGCTACAGCACtgttttttgaacaaaagccgttttgggatgca g" /listShort="ywmF" /listLong="csbD, S1417, S1416, ywzF, S1415, ywzE, S1414, S1413, ureA, ureB, ureC, S1412, ywnA" /label="upshifts" promotor_-35 complement(3395258..3395264) /Source="Nicolas_upshift_promotors" /id="U2882" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=97 /SigmaFactorBS="tttatgcaaaaaaaggggagcatcggaaCGTTTATttccggg gagaacAGGAAAAATCGCTACAGCACtgttttttgaacaaaagccgttttgggatgca g" /listShort="ywmF" /listLong="csbD, S1417, S1416, ywzF, S1415, ywzE, S1414, S1413, ureA, ureB, ureC, S1412, ywnA" /label="promotor_-35" CDS complement(3395324..3396457) /gene="rapB" /locus_tag="BSU_36690" /old_locus_tag="BSU36690" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9843420, 10629174, 12875849, 19332814, 19684115" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9843420, 10629174, 12875849, 19332814, 19684115; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="response regulator aspartate phosphatase" /protein_id="NP_391550.1" /db_xref="EnsemblGenomes-Gn:BSU36690" /db_xref="EnsemblGenomes-Tr:CAB15686" /db_xref="GOA:P70962" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="SubtiList:BG11965" /db_xref="UniProtKB/Swiss-Prot:P70962" /translation="MAAYEIPSSQVGVKINKWYKHILAFQVADAVKLKEEIDLDIEQM EEDQLLLLYYQLISYRHQIMLDYVKPDLHEESQLQYRELIKTLESNQDSISGLSEYYF HLFRGMYEFEQNNYISAISFYRKAEKMLAFVEDEIERAEFHFKVAEVFYIMKQTHFSM NHAVQALETYKAHDFYRVRRIQCHFVISGNYIDYRNYEKALEHLDDAYRLALLEGQPR LIGSALYNIGNCYDDKGELDQAAEYFEKALPVFEDYQLEQLPKALFSLTRVLFKKQDS EAAIRYYEKGIAIAQKRNDFFSLAKYKFLQALYVESVNLNMIQEVFDYMEEKGLYVYI EEFALDAASYFSHREQYKEAVYFYEKAVSMREMIQRNDCLYEV*" /label="rapB CDS" gene complement(3395324..3396457) /gene="rapB" /locus_tag="BSU_36690" /old_locus_tag="BSU36690" /label="rapB gene" downshifts complement(3395342) /Source="Nicolas_upshifts" /id="D1901" /incds=0 /nref=244 /ntot=265 /MaxReadThrough="2.8683" /MaxDrop="6.81344" /score="30.5146793" /energy="-8.1" /TU="NA" /idTUdmin="U2883" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(3396484..3396503) /Source="Nicolas_upshift_promotors" /id="U2883" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2953 /SigmaFactorBS="cataaagaaggaatcattgtaagaaaatttaattccaaagcc atacatTATGATAAAATATAACCAATtagaaaatagaaagggttggaggggcatggcc g" /listShort="rapB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3396491) /Source="Nicolas_upshifts" /id="U2883" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2953 /SigmaFactorBS="cataaagaaggaatcattgtaagaaaatttaattccaaagcc atacatTATGATAAAATATAACCAATtagaaaatagaaagggttggaggggcatggcc g" /listShort="rapB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3396554..3396572) /Source="Nicolas_upshift_promotors" /id="U2884" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=2786 /SigmaFactorBS="tcggcactgtccggtaagcttttttattagaatccgaGTGCA AAAaatacgtagaaaaACCGAAATATATAAGGATAggcataaagaaggaatcattgta a" /listShort="rapB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3396570) /Source="Nicolas_upshifts" /id="U2884" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=2786 /SigmaFactorBS="tcggcactgtccggtaagcttttttattagaatccgaGTGCA AAAaatacgtagaaaaACCGAAATATATAAGGATAggcataaagaaggaatcattgta a" /listShort="rapB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3396586..3396593) /Source="Nicolas_upshift_promotors" /id="U2884" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=2786 /SigmaFactorBS="tcggcactgtccggtaagcttttttattagaatccgaGTGCA AAAaatacgtagaaaaACCGAAATATATAAGGATAggcataaagaaggaatcattgta a" /listShort="rapB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3396649..3397674) /gene="moaA" /locus_tag="BSU_36700" /old_locus_tag="BSU36700" /EC_number="4.1.99.22" /function="16.10: Respire" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 2170340, 7860592, 16632608, 19566093, 23286307, 25896388, 25941396, 26575208; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GTP 3',8-cyclase" /protein_id="NP_391551.1" /db_xref="EnsemblGenomes-Gn:BSU36700" /db_xref="EnsemblGenomes-Tr:CAB15687" /db_xref="GOA:P39757" /db_xref="InterPro:IPR000385" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR010505" /db_xref="InterPro:IPR013483" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR034395" /db_xref="InterPro:IPR034481" /db_xref="SubtiList:BG10980" /db_xref="UniProtKB/Swiss-Prot:P39757" /translation="MITESRQMLDKRNRPLRDLRISVTDRCNFRCTYCMPAELFGPDY PFLKKEELLSFEELERLATLFVTRFGVEKIRLTGGEPLMRKDMPELIKKLARIPGIRD IAMTTNGSLLPVYAKRLKEAGLKRVTISLDSLEDERFKKINGRGVSVSKVLEGIEAAK QAGLGVKINMVVQKGVNEKDILPMARYFKEKGHILRFIEFMDVGNTNQWEKKDVMTKA EIIDLINKHMPVEPIAPNYIGEVASRFRYLDGSGEIGVISSVSDAFCGSCNRARLSAR GELFTCLFASSGFDLRAPVRQELSDDELSEMIGTVWKNRIDQYSVDRTLSKASGKKKV EMSYIGG*" /label="moaA CDS" gene complement(3396649..3397674) /gene="moaA" /locus_tag="BSU_36700" /old_locus_tag="BSU36700" /label="moaA gene" downshifts complement(3396662) /Source="Nicolas_upshifts" /id="D1902" /incds=0 /nref=23 /ntot=147 /MaxReadThrough="3.05546" /MaxDrop="3.66108" /score="13.625744" /energy="-10.8" /TU="NA" /idTUdmin="U2885" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3397690..3398478) /gene="fdhD" /locus_tag="BSU_36710" /old_locus_tag="BSU36710" /function="16.11: Scavenge (Catabolism)" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2170340, 7860592, 19114526, 20011599, 22194618; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein sulfur transferase involved in molybdenum cofactor synthesis" /protein_id="NP_391552.1" /db_xref="EnsemblGenomes-Gn:BSU36710" /db_xref="EnsemblGenomes-Tr:CAB15688" /db_xref="GOA:P39756" /db_xref="InterPro:IPR003786" /db_xref="InterPro:IPR016193" /db_xref="SubtiList:BG10979" /db_xref="UniProtKB/Swiss-Prot:P39756" /translation="MNDKVTAVRDVWRYEQGEISKVEDRMVTEFPLTVILNGSEFVTL VCTPEHIEELVIGFLASEGVIRFQKEIKRFTIDESLGFVYVDLVHPETLDQKDYTKRV IGSCCGKGRHFYFQQDVKTAKTAVSQIKISPEACLALMKDMQQGSGTFQDTGGVHNAA LCDTEKLLLMRTDIGRHNALDKLYGHCLLNGMSVRDKLIVFSGRISSEVLLKAAKIGV SIVISKSAPTELAIQMAEELNITAIGFVRNGSFNVYTHPERIRE*" /label="fdhD CDS" gene complement(3397690..3398478) /gene="fdhD" /locus_tag="BSU_36710" /old_locus_tag="BSU36710" /label="fdhD gene" promotor_-10 complement(3398504..3398523) /Source="Nicolas_upshift_promotors" /id="U2885" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.965034965034965" /psig="0.986013986013986" /xcortree=1964 /SigmaFactorBS="tatagagggctctttttgtgtctcagAATTCGACaaaatccg aggagTGTGAAAAAATATAAAGGCAggaacattgcggaggggaagagacattgaacga t" /listShort="fdhD, moaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3398510) /Source="Nicolas_upshifts" /id="U2885" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.965034965034965" /psig="0.986013986013986" /xcortree=1964 /SigmaFactorBS="tatagagggctctttttgtgtctcagAATTCGACaaaatccg aggagTGTGAAAAAATATAAAGGCAggaacattgcggaggggaagagacattgaacga t" /listShort="fdhD, moaA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3398512..3398723) /Source="Nicolas_S_feature" /locus_tag="new_3774188_3774399_c" /HighExp="Etha, Sw, Salt, Heat, S8, Gly, S6, S7, BC, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.16930300000000001" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1418" promotor_-35 complement(3398537..3398544) /Source="Nicolas_upshift_promotors" /id="U2885" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.965034965034965" /psig="0.986013986013986" /xcortree=1964 /SigmaFactorBS="tatagagggctctttttgtgtctcagAATTCGACaaaatccg aggagTGTGAAAAAATATAAAGGCAggaacattgcggaggggaagagacattgaacga t" /listShort="fdhD, moaA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3398724..3398885) /gene="ywmE" /locus_tag="BSU_36720" /old_locus_tag="BSU36720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391553.1" /db_xref="EnsemblGenomes-Gn:BSU36720" /db_xref="EnsemblGenomes-Tr:CAB15689" /db_xref="GOA:P70966" /db_xref="SubtiList:BG12476" /db_xref="UniProtKB/Swiss-Prot:P70966" /translation="MKLFGMIFLIATVAFILLGVLLKLAAFFFVSILTLIAAIVLFTV LKKNQHNQT*" /label="ywmE CDS" gene complement(3398724..3398885) /gene="ywmE" /locus_tag="BSU_36720" /old_locus_tag="BSU36720" /label="ywmE gene" promotor_-10 complement(3398898..3398916) /Source="Nicolas_upshift_promotors" /id="U2886" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=166 /SigmaFactorBS="ggaacctaaagatcaggcgctcccccaggcgccttttttatt GGTTTAAaaacagtttgggcGGGAATGATACCCTAAAAAggggttgaacatatgaaat t" /listShort="ywmE, S1418" /listLong="fdhD, moaA" /label="promotor_-10" upshifts complement(3398918) /Source="Nicolas_upshifts" /id="U2886" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=166 /SigmaFactorBS="ggaacctaaagatcaggcgctcccccaggcgccttttttatt GGTTTAAaaacagtttgggcGGGAATGATACCCTAAAAAggggttgaacatatgaaat t" /listShort="ywmE, S1418" /listLong="fdhD, moaA" /label="upshifts" promotor_-35 complement(3398930..3398936) /Source="Nicolas_upshift_promotors" /id="U2886" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=166 /SigmaFactorBS="ggaacctaaagatcaggcgctcccccaggcgccttttttatt GGTTTAAaaacagtttgggcGGGAATGATACCCTAAAAAggggttgaacatatgaaat t" /listShort="ywmE, S1418" /listLong="fdhD, moaA" /label="promotor_-35" CDS complement(3398979..3399653) /gene="ywmD" /locus_tag="BSU_36730" /old_locus_tag="BSU36730" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_391554.1" /db_xref="EnsemblGenomes-Gn:BSU36730" /db_xref="EnsemblGenomes-Tr:CAB15690" /db_xref="InterPro:IPR002035" /db_xref="InterPro:IPR036465" /db_xref="SubtiList:BG12475" /db_xref="UniProtKB/Swiss-Prot:P70961" /translation="MKKLLAAGIIGLLTVSIASPSFAAEKQADTNVAVLFDGSGSMVQ KTGGERKIDIAKKSVKSFAELLPKDTNLMLRVFGHAGNNKLSGKALSCSTTETIYGLH PYEGSLFDNSLSELKPTGWTPIAKALADTRKEFEAFDADGKNVVYLITDGEETCGGDP AAEIEKLRASNVDTIVNIIGFNFDVKGNEEMKQAAVAGGGEYISANSADEFEQAWEKE AQKFTE*" /label="ywmD CDS" gene complement(3398979..3399653) /gene="ywmD" /locus_tag="BSU_36730" /old_locus_tag="BSU36730" /label="ywmD gene" downshifts complement(3398994) /Source="Nicolas_upshifts" /id="D1903" /incds=0 /nref=16 /ntot=88 /MaxReadThrough="0.76221" /MaxDrop="4.19611" /score="25.2461653" /energy="-9.6" /TU="NA" /idTUdmin="U2886" /TUdmin="-462" /isTUend="FALSE" /label="downshifts" CDS complement(3399706..3399846) /locus_tag="BSU_36739" /old_locus_tag="BSU36739" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514009.1" /translation="MITQAVYAFWAEMAKNERHFKRFWTDRESSTKGSMSYIFLHFRI LA*" /label="hypothetical protein CDS" gene complement(3399706..3399846) /locus_tag="BSU_36739" /old_locus_tag="BSU36739" /label="gene" CDS complement(3399977..3400660) /gene="ywmC" /locus_tag="BSU_36740" /old_locus_tag="BSU36740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_391555.1" /db_xref="EnsemblGenomes-Gn:BSU36740" /db_xref="EnsemblGenomes-Tr:CAB15691" /db_xref="InterPro:IPR002035" /db_xref="InterPro:IPR036465" /db_xref="SubtiList:BG12474" /db_xref="UniProtKB/Swiss-Prot:P70960" /translation="MKKRFSLIMMTGLLFGLTSPAFAAEKTETEAKAPANVAVLLDAS GSMAKRIDGVSKFNSAKKEISKFASSLPEGTQVKMSVFGSEGNNKNSGKVQSCEAIRN VYGFQSFNEQSFLNSLNTIGPTGWTPIAKALNEAKSSFDQLDAKGEKVVYLLTDGEET CGGNPIKTAKELQKDNITVNVIGFDYKEGYKGQLNAIAKVGGGEYFPAYTQKDVEKIF TQQSLMLSK*" /label="ywmC CDS" gene complement(3399977..3400660) /gene="ywmC" /locus_tag="BSU_36740" /old_locus_tag="BSU36740" /label="ywmC gene" promotor_-35 3401037..3401041 /Source="Nicolas_upshift_promotors" /id="U2887" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.687312687312687" /psig="0.687312687312687" /xcortree=1394 /SigmaFactorBS="aacagaaaaagacgcccaatgagCGTCTttttctactttttc GCCATATATTTATTCAAAAAcgcatctgcctcagaaatttgtgtgccttggtaatagt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3401046..3402077) /gene="spoIID" /locus_tag="BSU_36750" /old_locus_tag="BSU36750" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15752199, 16959571, 17376078, 27226615" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15752199, 16959571, 17376078, 27226615; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="lytic transglycosylase; autolysin required for complete dissolution of the asymmetric septum (stage II sporulation)" /protein_id="NP_391556.1" /db_xref="EnsemblGenomes-Gn:BSU36750" /db_xref="EnsemblGenomes-Tr:CAB15692" /db_xref="GOA:P07372" /db_xref="InterPro:IPR013486" /db_xref="InterPro:IPR013693" /db_xref="InterPro:IPR014225" /db_xref="SubtiList:BG10766" /db_xref="UniProtKB/Swiss-Prot:P07372" /translation="MKQFAITLSVLCALILLVPTLLVIPFQHNKEAGASVESEKTAVS TKPASKGAETLKASPVSIPVYRTANQSVENIPLEEYVIGVVASEMPATFKPEALKAQA LAARTFIVRLMVSNSAVEAPKGSLVDDTQMFQVYKSKAELKKQWGTSYETKLKKITDA VASTQGKILTYNNQPIEASFFSTSNGYTENAEAYWTSAIPYLKSVKSPWDKKSPKYKA TKTFTAAEFQQKLGVKLDGSSAVGKITGETPGHQVATAVINGKTLKGRDIREKLGLNS ADFEWKRNGDTITVTTRGFGHGVGMSQYGANFMAKEGKTVDDIVKYYYQGTQISEADA FLNKYMAKK*" /label="spoIID CDS" gene complement(3401046..3402077) /gene="spoIID" /locus_tag="BSU_36750" /old_locus_tag="BSU36750" /label="spoIID gene" promotor_-10 3401056..3401075 /Source="Nicolas_upshift_promotors" /id="U2887" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.687312687312687" /psig="0.687312687312687" /xcortree=1394 /SigmaFactorBS="aacagaaaaagacgcccaatgagCGTCTttttctactttttc GCCATATATTTATTCAAAAAcgcatctgcctcagaaatttgtgtgccttggtaatagt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(3401062) /Source="Nicolas_upshifts" /id="D1904" /incds=0 /nref=56 /ntot=156 /MaxReadThrough="0.87893" /MaxDrop="6.31542" /score="12.1351765" /energy="-8.7" /TU="NA" /idTUdmin="U2888" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts 3401074 /Source="Nicolas_upshifts" /id="U2887" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.687312687312687" /psig="0.687312687312687" /xcortree=1394 /SigmaFactorBS="aacagaaaaagacgcccaatgagCGTCTttttctactttttc GCCATATATTTATTCAAAAAcgcatctgcctcagaaatttgtgtgccttggtaatagt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3402105..3402123) /Source="Nicolas_upshift_promotors" /id="U2888" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=978 /SigmaFactorBS="taaatgacaaataaagtttctgtccaaaacgagaGTCATAtt agcttgtccctgcCCATAGACTAGACTAGAGTcgaatcccgagcaggaggcagctgaa t" /listShort="spoIID" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3402118) /Source="Nicolas_upshifts" /id="U2888" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=978 /SigmaFactorBS="taaatgacaaataaagtttctgtccaaaacgagaGTCATAtt agcttgtccctgcCCATAGACTAGACTAGAGTcgaatcccgagcaggaggcagctgaa t" /listShort="spoIID" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3402120..3402237) /Source="Nicolas_S_feature" /locus_tag="new_3777796_3777913_c" /HighExp="S8, M40t90, M9-stat, B36, LBGtran, G180, H2O2, M0t90, BT, T1.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigI, SigWXY, SigA" /TUshortPSig="0.947, 0.999, 1, 0.973" /TUlongSig="SigL, SigA, SigA" /TUlongPSig="0.722, 0.998, 1" /label="S1419" promotor_-35 complement(3402139..3402144) /Source="Nicolas_upshift_promotors" /id="U2888" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=978 /SigmaFactorBS="taaatgacaaataaagtttctgtccaaaacgagaGTCATAtt agcttgtccctgcCCATAGACTAGACTAGAGTcgaatcccgagcaggaggcagctgaa t" /listShort="spoIID" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3402179..3402184 /Source="Nicolas_upshift_promotors" /id="U2889" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1072 /SigmaFactorBS="taatatgactctcgttttggacagaaactttatttgtcattt aCGTATTcttttttgctattttGCGCATAATGATGATAATAcacaaaaaataaaaaac c" /listShort="S1420, ywmA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3402196..3404856 /Source="Nicolas_S_feature" /locus_tag="new_3777872_3780532" /HighExp="S8, S6, S7, S4, S3, C30, S5, T5.0H, T3.30H, BT" /AntisenseName="murAA" /AntisenseCor="5.8371061376981899E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.971" /TUlongSig="NA" /TUlongPSig="NA" /label="S1420" upshifts 3402196 /Source="Nicolas_upshifts" /id="U2889" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1072 /SigmaFactorBS="taatatgactctcgttttggacagaaactttatttgtcattt aCGTATTcttttttgctattttGCGCATAATGATGATAATAcacaaaaaataaaaaac c" /listShort="S1420, ywmA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3402200..3402218 /Source="Nicolas_upshift_promotors" /id="U2889" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1072 /SigmaFactorBS="taatatgactctcgttttggacagaaactttatttgtcattt aCGTATTcttttttgctattttGCGCATAATGATGATAATAcacaaaaaataaaaaac c" /listShort="S1420, ywmA" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(3402273..3403583) /gene="murAA" /locus_tag="BSU_36760" /old_locus_tag="BSU36760" /EC_number="2.5.1.7" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12682299, 14763982, 17714441" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14763982, 17714441; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylglucosamine 1-carboxyvinyltransferase" /protein_id="NP_391557.1" /db_xref="EnsemblGenomes-Gn:BSU36760" /db_xref="EnsemblGenomes-Tr:CAB15693" /db_xref="GOA:P70965" /db_xref="InterPro:IPR001986" /db_xref="InterPro:IPR005750" /db_xref="InterPro:IPR013792" /db_xref="InterPro:IPR036968" /db_xref="SubtiList:BG11955" /db_xref="UniProtKB/Swiss-Prot:P70965" /translation="MEKIIVRGGQKLNGTVKVEGAKNAVLPVIAASLLASEEKSVICD VPTLSDVYTINEVLRHLGADVHFENNEVTVNASYALQTEAPFEYVRKMRASVLVMGPL LARTGHARVALPGGCAIGSRPIDQHLKGFEAMGAEIKVGNGFIEAEVKGRLQGAKIYL DFPSVGATENLIMAAALAEGTTTLENVAKEPEIVDLANYINGMGGKIRGAGTGTIKIE GVEKLHGVKHHIIPDRIEAGTFMVAAAITEGNVLVKGAVPEHLTSLIAKMEEMGVTIK DEGEGLRVIGPKELKPIDIKTMPHPGFPTDMQSQMMALLLRASGTSMITETVFENRFM HAEEFRRMNGDIKIEGRSVIINGPVQLQGAEVAATDLRAGAALILAGLVAEGHTRVTE LKHLDRGYVDFHQKLAALGADIERVNDESASEQENKEVVSDLNA*" /label="murAA CDS" gene complement(3402273..3403583) /gene="murAA" /locus_tag="BSU_36760" /old_locus_tag="BSU36760" /label="murAA gene" downshifts complement(3402282) /Source="Nicolas_upshifts" /id="D1905" /incds=0 /nref=171 /ntot=256 /MaxReadThrough="5.3301" /MaxDrop="5.5423" /score="31.3825723" /energy="-11.8" /TU="U2890,U2891,U2892,U2894" /idTUdmin="U2890" /TUdmin="-98" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3403607..3403626) /Source="Nicolas_upshift_promotors" /id="U2890" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.947052947052947" /psig="0.947052947052947" /xcortree=752 /SigmaFactorBS="aatgggcggaaaacataccgttacgGTTGGCACACcaatcgt tacgacTGAATATTAATATAGAGAATttagggacgcggaggggaataccttggaaaaa a" /listShort="murAA, S1419" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3403614) /Source="Nicolas_upshifts" /id="U2890" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.947052947052947" /psig="0.947052947052947" /xcortree=752 /SigmaFactorBS="aatgggcggaaaacataccgttacgGTTGGCACACcaatcgt tacgacTGAATATTAATATAGAGAATttagggacgcggaggggaataccttggaaaaa a" /listShort="murAA, S1419" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3403617..3404357) /gene="ywmB" /locus_tag="BSU_36770" /old_locus_tag="BSU36770" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391558.1" /db_xref="EnsemblGenomes-Gn:BSU36770" /db_xref="EnsemblGenomes-Tr:CAB15694" /db_xref="InterPro:IPR014794" /db_xref="InterPro:IPR036209" /db_xref="PDB:2FPN" /db_xref="SubtiList:BG12473" /db_xref="UniProtKB/Swiss-Prot:O32277" /translation="MKKKQVSHAIIISVMLSFVIAVFHTIHASELTPLAQMAEGMERQ DVSIDKWTLHAKQNLSLTEKEFYQKVQRLKQEYRQYDWVIAREDKMIKAIGTYTDKKN RTSFRLQLVTTLKKHNPTSYLLYEQMSLETPDSWNDTYEQFERETLGIFQEKVVIFTC LNGHLDDNMNIVLQKKANQLLNEFQARSVEHVVEPNFVSISAFTDEWEEYIMTSKHKM NLQIALRSAGMGGKHTVTVGTPIVTTEY*" /label="ywmB CDS" gene complement(3403617..3404357) /gene="ywmB" /locus_tag="BSU_36770" /old_locus_tag="BSU36770" /label="ywmB gene" promotor_-35 complement(3403640..3403649) /Source="Nicolas_upshift_promotors" /id="U2890" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.947052947052947" /psig="0.947052947052947" /xcortree=752 /SigmaFactorBS="aatgggcggaaaacataccgttacgGTTGGCACACcaatcgt tacgacTGAATATTAATATAGAGAATttagggacgcggaggggaataccttggaaaaa a" /listShort="murAA, S1419" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3403988) /Source="Nicolas_upshifts" /id="U2891" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1770 /SigmaFactorBS="acttcttttagactgcagcttgtcacaaCCCTCAAAAaacac aatccaacTTCGTATTTattatatgagcaaatgagtctagagacaccggatagctgga a" /listShort="murAA, S1419, spoIID" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3403990..3403998) /Source="Nicolas_upshift_promotors" /id="U2891" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1770 /SigmaFactorBS="acttcttttagactgcagcttgtcacaaCCCTCAAAAaacac aatccaacTTCGTATTTattatatgagcaaatgagtctagagacaccggatagctgga a" /listShort="murAA, S1419, spoIID" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3404012..3404020) /Source="Nicolas_upshift_promotors" /id="U2891" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1770 /SigmaFactorBS="acttcttttagactgcagcttgtcacaaCCCTCAAAAaacac aatccaacTTCGTATTTattatatgagcaaatgagtctagagacaccggatagctgga a" /listShort="murAA, S1419, spoIID" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3404112..3404127) /Source="Nicolas_upshift_promotors" /id="U2892" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2506 /SigmaFactorBS="tcactgaccgaaaaagaattttatcaaaaagTGCAACGTTTa aaacaagagtaTCGTCAATATGATTGGgtgattgcacgggaagataaaatgataaagg c" /listShort="murAA, S1419, spoIID" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3404120) /Source="Nicolas_upshifts" /id="U2892" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2506 /SigmaFactorBS="tcactgaccgaaaaagaattttatcaaaaagTGCAACGTTTa aaacaagagtaTCGTCAATATGATTGGgtgattgcacgggaagataaaatgataaagg c" /listShort="murAA, S1419, spoIID" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3404140..3404149) /Source="Nicolas_upshift_promotors" /id="U2892" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2506 /SigmaFactorBS="tcactgaccgaaaaagaattttatcaaaaagTGCAACGTTTa aaacaagagtaTCGTCAATATGATTGGgtgattgcacgggaagataaaatgataaagg c" /listShort="murAA, S1419, spoIID" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3404358..3404485) /Source="Nicolas_S_feature" /locus_tag="new_3780034_3780161_c" /HighExp="UNK1, S2, Lbexp, MG 60, MG 15, M9-tran, M/G, G135, MG 5, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.973" /TUlongSig="SigL, SigA, SigA" /TUlongPSig="0.722, 0.998, 1" /label="S1421" CDS complement(3404486..3404716) /gene="ywzB" /locus_tag="BSU_36780" /old_locus_tag="BSU36780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391559.1" /db_xref="EnsemblGenomes-Gn:BSU36780" /db_xref="EnsemblGenomes-Tr:CAB15695" /db_xref="GOA:O32278" /db_xref="InterPro:IPR009526" /db_xref="SubtiList:BG14163" /db_xref="UniProtKB/Swiss-Prot:O32278" /translation="MSVLGQQAAIGIVVHLIFIAVTWWALQAVNIDPLIKKGKVVQAR LLMILLTIAIGTAVANFFLDYLNYSQQLPYLF*" /label="ywzB CDS" gene complement(3404486..3404716) /gene="ywzB" /locus_tag="BSU_36780" /old_locus_tag="BSU36780" /label="ywzB gene" S_feature complement(3404717..3404979) /Source="Nicolas_S_feature" /locus_tag="new_3780393_3780655_c" /HighExp="UNK1, S2, Lbexp, MG 5, M9-tran, M/G, MG 15, MG 60, GM 15, MG t5" /AntisenseName="ywmA" /AntisenseCor="-0.24099136307237601" /AntisenseRegPval="-4.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.973" /TUlongSig="SigL, SigA, SigA" /TUlongPSig="0.722, 0.998, 1" /label="S1422" misc_feature 3404852..3404871 /Source="Nicolas_upshift_promotors" /id="U2893" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.828171828171828" /psig=1 /xcortree=411 /SigmaFactorBS="cggaataatcagccaaatctagggctaatccccgcttaaagt gcgattcttttaCATGGTATACTTTATTGGAAaggagctggcaaatgtgaatcattct t" /listShort="ywmA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3404858 /Source="Nicolas_upshifts" /id="U2893" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.828171828171828" /psig=1 /xcortree=411 /SigmaFactorBS="cggaataatcagccaaatctagggctaatccccgcttaaagt gcgattcttttaCATGGTATACTTTATTGGAAaggagctggcaaatgtgaatcattct t" /listShort="ywmA" /GFF_Attribute="listLong" /label="upshifts" CDS 3404886..3405359 /gene="ywmA" /locus_tag="BSU_36790" /old_locus_tag="BSU36790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391560.1" /db_xref="EnsemblGenomes-Gn:BSU36790" /db_xref="EnsemblGenomes-Tr:CAB15696" /db_xref="SubtiList:BG12472" /db_xref="UniProtKB/Swiss-Prot:P70958" /translation="MNHSFFQPEKQYGEDLPIFDQEWEAIAFYYDYRQSQIEELNELC QFFNISLTYTRESLEELENLYFQSIQELLLADWNLPIEEFEKMISVYLIDCVIARHED AEWVVKPYPYKDGAYTLGFRRHRKSWHTMNACDGLYLRPKEDRPLLSLFDSLVRS*" /label="ywmA CDS" gene 3404886..3405359 /gene="ywmA" /locus_tag="BSU_36790" /old_locus_tag="BSU36790" /label="ywmA gene" promotor_-10 complement(3404963..3404982) /Source="Nicolas_upshift_promotors" /id="U2894" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.843156843156843" /psig="0.973026973026973" /xcortree=2712 /SigmaFactorBS="taagagaaatgttaaaaaactgacacaattcattcagttCTT CaatctgtgactgtcTATAATCATAATAGAATGCAattgcttcccattcctgatcaaa a" /listShort="S1422, ywzB, S1421, ywmB, murAA, S1419" /listLong="spoIID" /label="promotor_-10" upshifts complement(3404979) /Source="Nicolas_upshifts" /id="U2894" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.843156843156843" /psig="0.973026973026973" /xcortree=2712 /SigmaFactorBS="taagagaaatgttaaaaaactgacacaattcattcagttCTT CaatctgtgactgtcTATAATCATAATAGAATGCAattgcttcccattcctgatcaaa a" /listShort="S1422, ywzB, S1421, ywmB, murAA, S1419" /listLong="spoIID" /label="upshifts" S_feature complement(3404981..3405364) /Source="Nicolas_S_feature" /locus_tag="new_3780657_3781040_c" /HighExp="G135, G180, G150, H2O2, Oxctl, Paraq, Cold, M9-stat, C30, S0" /AntisenseName="ywmA" /AntisenseCor="-1.9581968147303098E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigL, SigA" /TUshortPSig="0.722, 0.998" /TUlongSig="SigA" /TUlongPSig=1 /label="S1423" promotor_-35 complement(3404997..3405000) /Source="Nicolas_upshift_promotors" /id="U2894" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.843156843156843" /psig="0.973026973026973" /xcortree=2712 /SigmaFactorBS="taagagaaatgttaaaaaactgacacaattcattcagttCTT CaatctgtgactgtcTATAATCATAATAGAATGCAattgcttcccattcctgatcaaa a" /listShort="S1422, ywzB, S1421, ywmB, murAA, S1419" /listLong="spoIID" /label="promotor_-35" CDS complement(3405393..3405791) /gene="atpC" /locus_tag="BSU_36800" /old_locus_tag="BSU36800" /EC_number="3.6.3.14" /function="16.7: Manage energy" /experiment="publication(s) with functional evidences, PMID:8021203, 12837747, 15347741, 22720735, 23967352" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8021203, 12837747, 15347741, 22720735, 23967352; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit epsilon, F1 subunit)" /protein_id="NP_391561.1" /db_xref="EnsemblGenomes-Gn:BSU36800" /db_xref="EnsemblGenomes-Tr:CAB15697" /db_xref="GOA:P37812" /db_xref="InterPro:IPR001469" /db_xref="InterPro:IPR020546" /db_xref="InterPro:IPR020547" /db_xref="InterPro:IPR036771" /db_xref="InterPro:IPR036794" /db_xref="SubtiList:BG10822" /db_xref="UniProtKB/Swiss-Prot:P37812" /translation="MKTVKVNIVTPDGPVYDADIEMVSVRAESGDLGILPGHIPTVAP LKIGAVRLKKDGQTEMVAVSGGFVEVRPDHVTILAQAAETAEGIDKERAEAARQRAQE RLNSQSDDTDIRRAELALQRALNRLDVAGK*" /label="atpC CDS" gene complement(3405393..3405791) /gene="atpC" /locus_tag="BSU_36800" /old_locus_tag="BSU36800" /label="atpC gene" downshifts complement(3405409) /Source="Nicolas_upshifts" /id="D1906" /incds=0 /nref=283 /ntot=320 /MaxReadThrough="4.15968" /MaxDrop="7.84101" /score="22.7623678" /energy="-10.8" /TU="U2897,U2899" /idTUdmin="U2895" /TUdmin=9 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3405783..3405801) /Source="Nicolas_upshift_promotors" /id="U2895" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=107 /SigmaFactorBS="ttgttgagaaagcaaaagaaatgggtgtagaAGTTTAAtctg gtcctaggaGGGTAAAAGCATGAAGACCgttaaagtcaatatcgttactcccgacggc c" /listShort="atpC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3405792) /Source="Nicolas_upshifts" /id="U2895" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=107 /SigmaFactorBS="ttgttgagaaagcaaaagaaatgggtgtagaAGTTTAAtctg gtcctaggaGGGTAAAAGCATGAAGACCgttaaagtcaatatcgttactcccgacggc c" /listShort="atpC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3405815..3405821) /Source="Nicolas_upshift_promotors" /id="U2895" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=107 /SigmaFactorBS="ttgttgagaaagcaaaagaaatgggtgtagaAGTTTAAtctg gtcctaggaGGGTAAAAGCATGAAGACCgttaaagtcaatatcgttactcccgacggc c" /listShort="atpC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3405815..3407236) /gene="atpD" /locus_tag="BSU_36810" /old_locus_tag="BSU36810" /EC_number="3.6.3.14" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:8021203, 15347741, 18174126, 22790590" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8021203, 15347741, 18174126, 22790590; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit beta, component F1)" /protein_id="NP_391562.1" /db_xref="EnsemblGenomes-Gn:BSU36810" /db_xref="EnsemblGenomes-Tr:CAB15698" /db_xref="GOA:P37809" /db_xref="InterPro:IPR000194" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004100" /db_xref="InterPro:IPR005722" /db_xref="InterPro:IPR020003" /db_xref="InterPro:IPR024034" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036121" /db_xref="SubtiList:BG10821" /db_xref="UniProtKB/Swiss-Prot:P37809" /translation="MKKGRVSQVLGPVVDVRFEDGHLPEIYNAIKISQPAASENEVGI DLTLEVALHLGDDTVRTIAMASTDGVQRGMEAVDTGAPISVPVGDVTLGRVFNVLGEN IDLNEPVPADAKKDPIHRQAPSFDQLSTEVEILETGIKVVDLLAPYIKGGKIGLFGGA GVGKTVLIQELINNIAQEHGGISVFAGVGERTREGNDLFYEMSDSGVINKTAMVFGQM NEPPGARMRVALTGLTMAEHFRDVQGQDVLFFIDNIFRFTQAGSEVSALLGRMPSAVG YQPTLATEMGQLQERITSTNVGSVTSIQAIYVPADDYTDPAPATTFAHLDATTNLERK LTEMGIYPAVDPLASTSRALAPEIVGEEHYAVAREVQSTLQRYKELQDIIAILGMDEL GEEDKLVVHRARRIQFFLSQNFHVAEQFTGQKGSYVPVKETVQGFKEILAGKYDHLPE DAFRLVGRIEEVVEKAKEMGVEV*" /label="atpD CDS" gene complement(3405815..3407236) /gene="atpD" /locus_tag="BSU_36810" /old_locus_tag="BSU36810" /label="atpD gene" CDS complement(3407262..3408125) /gene="atpG" /locus_tag="BSU_36820" /old_locus_tag="BSU36820" /EC_number="3.6.3.14" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:8021203, 15347741, 18174126, 22790590" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8021203, 15347741, 18174126, 22790590; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit gamma, component F1)" /protein_id="NP_391563.1" /db_xref="EnsemblGenomes-Gn:BSU36820" /db_xref="EnsemblGenomes-Tr:CAB15699" /db_xref="GOA:P37810" /db_xref="InterPro:IPR000131" /db_xref="InterPro:IPR023632" /db_xref="InterPro:IPR035968" /db_xref="SubtiList:BG10820" /db_xref="UniProtKB/Swiss-Prot:P37810" /translation="MASLRDIKSRITSTKKTSQITKAMQMVSAAKLNRAENNAKSFVP YMDKIQEVVSNVGRVSGNVKHPMLLSREVKKTAYLVITSDRGLAGAFNSSVLRSAYQA MQERHQSKDEYAVIAIGRVGRDFFKKREIPIISELTGLGDEVTFTEIKDLARQTIQMF IDGAFDELHLVYNHFVSAITQEVTEKKLLPLSDLGSGGGKRTASYEFEPSEEEVLEVL LPQYAESLIFGALLDSKASEHAARMTAMKNATDNAKELIDSLSLSYNRARQAAITQEI TEIVGGAAALE*" /label="atpG CDS" gene complement(3407262..3408125) /gene="atpG" /locus_tag="BSU_36820" /old_locus_tag="BSU36820" /label="atpG gene" S_feature complement(3408126..3408201) /Source="Nicolas_S_feature" /locus_tag="new_3783802_3783877_c" /HighExp="S0, S2, MG-0.2, MG-0.1, Mal, G150, BI, M0t45, G180, MG 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigL, SigA" /TUshortPSig="0.722, 0.998" /TUlongSig="SigA" /TUlongPSig=1 /label="S1424" CDS complement(3408202..3409710) /gene="atpA" /locus_tag="BSU_36830" /old_locus_tag="BSU36830" /EC_number="3.6.3.14" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:8021203, 15347741, 1655755" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8021203, 15347741, 1655755; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit alpha, component F1)" /protein_id="NP_391564.1" /db_xref="EnsemblGenomes-Gn:BSU36830" /db_xref="EnsemblGenomes-Tr:CAB15700" /db_xref="GOA:P37808" /db_xref="InterPro:IPR000194" /db_xref="InterPro:IPR000793" /db_xref="InterPro:IPR004100" /db_xref="InterPro:IPR005294" /db_xref="InterPro:IPR020003" /db_xref="InterPro:IPR023366" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR033732" /db_xref="InterPro:IPR036121" /db_xref="SubtiList:BG10819" /db_xref="UniProtKB/Swiss-Prot:P37808" /translation="MSIKAEEISTLIKQQIQNYQSDIEVQDVGTVIQVGDGIARVHGL DNCMAGELVEFSNGVLGMAQNLEESNVGIVILGPFSEIREGDEVKRTGRIMEVPVGEE LIGRIVNPLGQPVDGLGPILTSKTRPIESPAPGVMDRKSVHEPLQTGIKAIDALIPIG RGQRELIIGDRQTGKTSVAIDAILNQKDQDMICVYVAIGQKESTVRGVVETLRKHGAL DYTIVVTASASQPAPLLYLAPYAGVTMAEEFMYNGKHVLVVYDDLSKQAAAYRELSLL LRRPPGREAFPGDVFYLHSRLLERAAKLSDAKGAGSITALPFVETQAGDISAYIPTNV ISITDGQIFLQSDLFFSGVRPAINAGLSVSRVGGSAQIKAMKKVSGTLRLDLASYREL EAFAQFGSDLDQATQAKLNRGARTVEVLKQDLNKPLPVEKQVAILYALTKGYLDDIPV ADIRRFEEEYYMYLDQNHKDLLDGIAKTGNLPADEDFKAAIEGFKRTFAPSN*" /label="atpA CDS" gene complement(3408202..3409710) /gene="atpA" /locus_tag="BSU_36830" /old_locus_tag="BSU36830" /label="atpA gene" CDS complement(3409727..3410272) /gene="atpH" /locus_tag="BSU_36840" /old_locus_tag="BSU36840" /EC_number="3.6.3.14" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:8021203, 15347741, 1655755, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8021203, 15347741, 1655755, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit delta, component F1)" /protein_id="NP_391565.1" /db_xref="EnsemblGenomes-Gn:BSU36840" /db_xref="EnsemblGenomes-Tr:CAB15701" /db_xref="GOA:P37811" /db_xref="InterPro:IPR000711" /db_xref="InterPro:IPR020781" /db_xref="InterPro:IPR026015" /db_xref="SubtiList:BG10818" /db_xref="UniProtKB/Swiss-Prot:P37811" /translation="MSGSAVSKRYASALFDIANESAQLNQVEEELIVVKQVFQNEKAL NDVLNHPKVPAAKKKELIQNAFGSLSQSVLNTIFLLIDRHRAAIVPELTDEFIKLANV ARQTEDAIVYSVKPLTDAEMLPLSQVFAKKAGVASLRIRNEVQTDLIGGIKVRIGNRI YDGSVSGKLQRIERQLAGENR*" /label="atpH CDS" gene complement(3409727..3410272) /gene="atpH" /locus_tag="BSU_36840" /old_locus_tag="BSU36840" /label="atpH gene" CDS complement(3410269..3410781) /gene="atpF" /locus_tag="BSU_36850" /old_locus_tag="BSU36850" /EC_number="3.6.3.14" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1448623, 9069291, 15175330, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1448623, 9069291, 15175330, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit b, component F0)" /protein_id="NP_391566.1" /db_xref="EnsemblGenomes-Gn:BSU36850" /db_xref="EnsemblGenomes-Tr:CAB15702" /db_xref="GOA:P37814" /db_xref="InterPro:IPR002146" /db_xref="InterPro:IPR005864" /db_xref="InterPro:IPR028987" /db_xref="SubtiList:BG10817" /db_xref="UniProtKB/Swiss-Prot:P37814" /translation="MSQLPLELGLSFNGGDILFQLLAMLILLALLKKYALGPLLNIMK QREDHIAGEITSAEEKNKEAQQLIEEQRVLLKEARQESQTLIENAKKLGEKQKEEIIQ AARAESERLKEAARTEIVKEKEQAVSALREQVASLSVMIASKVIEKELDEQAQEKLIQ DYLKEVGESR*" /label="atpF CDS" gene complement(3410269..3410781) /gene="atpF" /locus_tag="BSU_36850" /old_locus_tag="BSU36850" /label="atpF gene" S_feature complement(3410782..3410943) /Source="Nicolas_S_feature" /locus_tag="new_3786458_3786619_c" /HighExp="S2, Lbstat, Mal, M40t90, M0t90, G150, MG-0.1, G135, M0t45, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigL, SigA" /TUshortPSig="0.722, 0.998" /TUlongSig="SigA" /TUlongPSig=1 /label="S1425" CDS complement(3410944..3411156) /gene="atpE" /locus_tag="BSU_36860" /old_locus_tag="BSU36860" /EC_number="3.6.3.14" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1448623, 9069291, 15175330" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1448623, 9069291, 15175330; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit c, component F0)" /protein_id="NP_391567.1" /db_xref="EnsemblGenomes-Gn:BSU36860" /db_xref="EnsemblGenomes-Tr:CAB15703" /db_xref="GOA:P37815" /db_xref="InterPro:IPR000454" /db_xref="InterPro:IPR002379" /db_xref="InterPro:IPR005953" /db_xref="InterPro:IPR020537" /db_xref="InterPro:IPR035921" /db_xref="SubtiList:BG10816" /db_xref="UniProtKB/Swiss-Prot:P37815" /translation="MNLIAAAIAIGLGALGAGIGNGLIVSRTVEGIARQPEAGKELRT LMFMGIALVEALPIIAVVIAFLAFFG*" /label="atpE CDS" gene complement(3410944..3411156) /gene="atpE" /locus_tag="BSU_36860" /old_locus_tag="BSU36860" /label="atpE gene" CDS complement(3411202..3411936) /gene="atpB" /locus_tag="BSU_36870" /old_locus_tag="BSU36870" /EC_number="3.6.3.14" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1448623, 9069291, 15175330, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1448623, 9069291, 15175330, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit a, component F0)" /protein_id="NP_391568.1" /db_xref="EnsemblGenomes-Gn:BSU36870" /db_xref="EnsemblGenomes-Tr:CAB15704" /db_xref="GOA:P37813" /db_xref="InterPro:IPR000568" /db_xref="InterPro:IPR023011" /db_xref="InterPro:IPR035908" /db_xref="SubtiList:BG10815" /db_xref="UniProtKB/Swiss-Prot:P37813" /translation="MNHGYRTIEFLGLTFNLTNILMITVASVIVLLIAILTTRTLSIR PGKAQNFMEWIVDFVRNIIGSTMDLKTGANFLALGVTLLMYIFVSNMLGLPFSITIGH ELWWKSPTADPAITLTLAVMVVALTHYYGVKMKGLKEYSKDYLRPVPFMLPMKIIEEF ANTLTLGLRLYGNIFAGEILLGLLAGLATSHYSQSVALGLVGTIGAILPMLAWQAFSL FIGAIQAFIFTMLTMVYMSHKISHDH*" /label="atpB CDS" gene complement(3411202..3411936) /gene="atpB" /locus_tag="BSU_36870" /old_locus_tag="BSU36870" /label="atpB gene" promotor_no_box 3411750..3411850 /Source="Nicolas_upshift_promotors" /id="U2896" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.974025974025974" /psig="0.002997002997003" /xcortree=76 /SigmaFactorBS="taatattgcggacgaaatcaacaatccattccataaagttct gggcttttccgggacggatcgaaagcgttcttgtcgtcaatatagcaatcaataaaac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 3411810 /Source="Nicolas_upshifts" /id="U2896" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.974025974025974" /psig="0.002997002997003" /xcortree=76 /SigmaFactorBS="taatattgcggacgaaatcaacaatccattccataaagttct gggcttttccgggacggatcgaaagcgttcttgtcgtcaatatagcaatcaataaaac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3411944..3412327) /gene="atpI" /locus_tag="BSU_36880" /old_locus_tag="BSU36880" /function="16.1: Circulate" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:12917488, 15849754, 16850406, 23123906" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12917488, 15849754, 16850406, 23123906; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit i)" /protein_id="NP_391569.1" /db_xref="EnsemblGenomes-Gn:BSU36880" /db_xref="EnsemblGenomes-Tr:CAB15705" /db_xref="GOA:P37816" /db_xref="InterPro:IPR005598" /db_xref="SubtiList:BG10814" /db_xref="UniProtKB/Swiss-Prot:P37816" /translation="MDDPKLTFSRQRKYLLFILAVYVLGYGLTAYKTVFLGLILGTVF SLFNFLLLVRRMNAFDRAVEKGKSIRSLGSAARWCNAILAVAVAYKNPEYFHMASTVI GLMTIYPVIMIDSFIQLKRSSMEER*" /label="atpI CDS" gene complement(3411944..3412327) /gene="atpI" /locus_tag="BSU_36880" /old_locus_tag="BSU36880" /label="atpI gene" misc_feature complement(3412016..3412034) /Source="Nicolas_upshift_promotors" /id="U2897" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.722277722277722" /psig="0.722277722277722" /xcortree=2708 /SigmaFactorBS="gctgtggctgttgcctataaaaatcccgaatactttcatatg gcAAGTACAGTTATTGGATTAatgacaatataccctgtcattatgatagattccttta t" /listShort="atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423" /listLong="S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3412018) /Source="Nicolas_upshifts" /id="U2897" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.722277722277722" /psig="0.722277722277722" /xcortree=2708 /SigmaFactorBS="gctgtggctgttgcctataaaaatcccgaatactttcatatg gcAAGTACAGTTATTGGATTAatgacaatataccctgtcattatgatagattccttta t" /listShort="atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423" /listLong="S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="upshifts" S_feature complement(3412328..3412598) /Source="Nicolas_S_feature" /locus_tag="new_3788004_3788274_c" /HighExp="M9-stat, T1.30H, T0.30H, T1.0H, UNK1, B60, G135, G180, G150, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 0.999" /TUlongSig="SigA, SigA" /TUlongPSig="1, 0.96" /label="S1426" promotor_-35 3412560..3412569 /Source="Nicolas_upshift_promotors" /id="U2898" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.955044955044955" /psig="0.955044955044955" /xcortree=1223 /SigmaFactorBS="ttgctgagaggatttacattgaggatgaggactataatgaaa gctatgaaaACCTTCTCATaataccctcgtttAGCATACAATAGCCCCTAACatgtgt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3412569 /Source="Nicolas_upshifts" /id="U2898" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.955044955044955" /psig="0.955044955044955" /xcortree=1223 /SigmaFactorBS="ttgctgagaggatttacattgaggatgaggactataatgaaa gctatgaaaACCTTCTCATaataccctcgtttAGCATACAATAGCCCCTAACatgtgt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3412574..3412593) /Source="Nicolas_upshift_promotors" /id="U2899" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.577422577422577" /psig="0.998001998001998" /xcortree=2710 /SigmaFactorBS="attctgtggagacgtaaagtataaaaagttttttaactttaa acaGATTGACAcatgttaggggcTATTGTATGCTAAACGAGGGtattatgagaaggtt t" /listShort="S1426, atpI, atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423" /listLong="S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="promotor_-10" promotor_-10 3412583..3412602 /Source="Nicolas_upshift_promotors" /id="U2898" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.955044955044955" /psig="0.955044955044955" /xcortree=1223 /SigmaFactorBS="ttgctgagaggatttacattgaggatgaggactataatgaaa gctatgaaaACCTTCTCATaataccctcgtttAGCATACAATAGCCCCTAACatgtgt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3412598) /Source="Nicolas_upshifts" /id="U2899" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.577422577422577" /psig="0.998001998001998" /xcortree=2710 /SigmaFactorBS="attctgtggagacgtaaagtataaaaagttttttaactttaa acaGATTGACAcatgttaggggcTATTGTATGCTAAACGAGGGtattatgagaaggtt t" /listShort="S1426, atpI, atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423" /listLong="S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="upshifts" S_feature complement(3412600..3412721) /Source="Nicolas_S_feature" /locus_tag="new_3788276_3788397_c" /HighExp="Etha, G180, H2O2, G135, Oxctl, G150, LBGexp, dia15, B36, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="SigA" /TUlongPSig="0.96" /label="S1427" promotor_-35 complement(3412606..3412613) /Source="Nicolas_upshift_promotors" /id="U2899" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.577422577422577" /psig="0.998001998001998" /xcortree=2710 /SigmaFactorBS="attctgtggagacgtaaagtataaaaagttttttaactttaa acaGATTGACAcatgttaggggcTATTGTATGCTAAACGAGGGtattatgagaaggtt t" /listShort="S1426, atpI, atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423" /listLong="S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="promotor_-35" CDS complement(3412750..3413379) /gene="upp" /locus_tag="BSU_36890" /old_locus_tag="BSU36890" /EC_number="2.4.2.9" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7798145, 15689504, 15716449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7798145, 15689504, 15716449; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="uracil phosphoribosyltransferase" /protein_id="NP_391570.1" /db_xref="EnsemblGenomes-Gn:BSU36890" /db_xref="EnsemblGenomes-Tr:CAB15706" /db_xref="GOA:P39149" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR005765" /db_xref="InterPro:IPR029057" /db_xref="InterPro:IPR034332" /db_xref="SubtiList:BG10945" /db_xref="UniProtKB/Swiss-Prot:P39149" /translation="MGKVYVFDHPLIQHKLTYIRNENTGTKDFRELVDEVATLMAFEI TRDLPLEEVDINTPVQAAKSKVISGKKLGVVPILRAGLGMVDGILKLIPAAKVGHVGL YRDPETLKPVEYYVKLPSDVEEREFIVVDPMLATGGSAVEAIHSLKKRGAKNIRFMCL VAAPEGVEELQKHHSDVDIYIAALDEKLNEKGYIVPGLGDAGDRMFGTK*" /label="upp CDS" gene complement(3412750..3413379) /gene="upp" /locus_tag="BSU_36890" /old_locus_tag="BSU36890" /label="upp gene" downshifts complement(3412766) /Source="Nicolas_upshifts" /id="D1907" /incds=0 /nref=180 /ntot=252 /MaxReadThrough="5.83241" /MaxDrop="5.91252" /score="1.39547358" /energy="-7.3" /TU="U2900,U2901" /idTUdmin="U2900" /TUdmin="-154" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3413423..3413442) /Source="Nicolas_upshift_promotors" /id="U2900" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.682317682317682" /psig=1 /xcortree=2556 /SigmaFactorBS="aaacccgcttgggcttatgcccggcgggttttttgacgatgt TCTTGAAActcaatgtctttttTTGTAGAATCAATAGAAGTGtgtaattgttgatggg a" /listShort="upp, S1427" /listLong="S1426, atpI, atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423, S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="promotor_-10" upshifts complement(3413446) /Source="Nicolas_upshifts" /id="U2900" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.682317682317682" /psig=1 /xcortree=2556 /SigmaFactorBS="aaacccgcttgggcttatgcccggcgggttttttgacgatgt TCTTGAAActcaatgtctttttTTGTAGAATCAATAGAAGTGtgtaattgttgatggg a" /listShort="upp, S1427" /listLong="S1426, atpI, atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423, S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="upshifts" promotor_-35 complement(3413457..3413464) /Source="Nicolas_upshift_promotors" /id="U2900" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.682317682317682" /psig=1 /xcortree=2556 /SigmaFactorBS="aaacccgcttgggcttatgcccggcgggttttttgacgatgt TCTTGAAActcaatgtctttttTTGTAGAATCAATAGAAGTGtgtaattgttgatggg a" /listShort="upp, S1427" /listLong="S1426, atpI, atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423, S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="promotor_-35" CDS complement(3413514..3414761) /gene="glyA" /locus_tag="BSU_36900" /old_locus_tag="BSU36900" /EC_number="2.1.2.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11390694, 11902725, 12682299, 12686103, 12923093, 15865438, 18483062" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11390694, 11902725, 12682299, 12686103, 12923093, 15865438, 18483062; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="serine hydroxymethyltransferase" /protein_id="NP_391571.1" /db_xref="EnsemblGenomes-Gn:BSU36900" /db_xref="EnsemblGenomes-Tr:CAB15707" /db_xref="GOA:P39148" /db_xref="InterPro:IPR001085" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR019798" /db_xref="SubtiList:BG10944" /db_xref="UniProtKB/Swiss-Prot:P39148" /translation="MKHLPAQDEQVFNAIKNERERQQTKIELIASENFVSEAVMEAQG SVLTNKYAEGYPGKRYYGGCEHVDVVEDIARDRAKEIFGAEHVNVQPHSGAQANMAVY FTILEQGDTVLGMNLSHGGHLTHGSPVNFSGVQYNFVEYGVDKETQYIDYDDVREKAL AHKPKLIVAGASAYPRTIDFKKFREIADEVGAYFMVDMAHIAGLVAAGLHPNPVPYAD FVTTTTHKTLRGPRGGMILCREEFGKKIDKSIFPGIQGGPLMHVIAAKAVSFGEVLQD DFKTYAQNVISNAKRLAEALTKEGIQLVSGGTDNHLILVDLRSLGLTGKVAEHVLDEI GITSNKNAIPYDPEKPFVTSGIRLGTAAVTSRGFDGDALEEVGAIIALALKNHEDEGK LEEARQRVAALTDKFPLYKELDY*" /label="glyA CDS" gene complement(3413514..3414761) /gene="glyA" /locus_tag="BSU_36900" /old_locus_tag="BSU36900" /label="glyA gene" downshifts complement(3413537) /Source="Nicolas_upshifts" /id="D1908" /incds=0 /nref=183 /ntot=229 /MaxReadThrough="5.99283" /MaxDrop="6.62881" /score="22.1245386" /energy="-15.8" /TU="U2901" /idTUdmin="U2902" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3414803..3414822) /Source="Nicolas_upshift_promotors" /id="U2901" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.495504495504495" /psig="0.999000999001" /xcortree=2312 /SigmaFactorBS="tttttaccaataaaaatttagattttttaaaaataatcTTTT ACatcggccttaaaaaCCATGTACAATAGTGATGGTaaaaacaaagaacaggatacgg a" /listShort="glyA, upp, S1427, S1426, atpI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3414820) /Source="Nicolas_upshifts" /id="U2901" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.495504495504495" /psig="0.999000999001" /xcortree=2312 /SigmaFactorBS="tttttaccaataaaaatttagattttttaaaaataatcTTTT ACatcggccttaaaaaCCATGTACAATAGTGATGGTaaaaacaaagaacaggatacgg a" /listShort="glyA, upp, S1427, S1426, atpI" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3414822..3414906) /Source="Nicolas_S_feature" /locus_tag="new_3790498_3790582_c" /HighExp="dia5, C90, dia15, Diami, Lbtran, LPhT, M40t45, H2O2, BI, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.96, 1" /TUlongSig="SigEF" /TUlongPSig="0.999" /label="S1428" promotor_-35 complement(3414837..3414842) /Source="Nicolas_upshift_promotors" /id="U2901" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.495504495504495" /psig="0.999000999001" /xcortree=2312 /SigmaFactorBS="tttttaccaataaaaatttagattttttaaaaataatcTTTT ACatcggccttaaaaaCCATGTACAATAGTGATGGTaaaaacaaagaacaggatacgg a" /listShort="glyA, upp, S1427, S1426, atpI" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3414951) /Source="Nicolas_upshifts" /id="D1909" /incds=0 /nref=3 /ntot=12 /MaxReadThrough="7.23859" /MaxDrop="5.0386" /score="-3.86767322" /energy="-4.3" /TU="U2902,U2903" /idTUdmin="U2904" /TUdmin=1137 /isTUend="FALSE" /label="downshifts" CDS complement(3414968..3415510) /gene="ywlG" /locus_tag="BSU_36910" /old_locus_tag="BSU36910" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15995210, 22333191" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391572.1" /db_xref="EnsemblGenomes-Gn:BSU36910" /db_xref="EnsemblGenomes-Tr:CAB15708" /db_xref="InterPro:IPR006340" /db_xref="InterPro:IPR028345" /db_xref="SubtiList:BG10943" /db_xref="UniProtKB/Swiss-Prot:P39157" /translation="MNELKQTWKTMLSEFQDQAELKQDQLFVLGCSTSEVAGSRIGTS GSVDIAESIYSGLAELREKTGIHLAFQCCEHLNRALVVEAETAKLFRLPTVSAVPVPK AGGAMASYAFKQMKSPVLVETIQADAGIDIGDTFIGMHLKPVAVPVRVSQNSLGSAHV TLARTRPKLIGGVRAVYECE*" /label="ywlG CDS" gene complement(3414968..3415510) /gene="ywlG" /locus_tag="BSU_36910" /old_locus_tag="BSU36910" /label="ywlG gene" CDS complement(3415523..3415972) /gene="rpiB" /locus_tag="BSU_36920" /old_locus_tag="BSU36920" /EC_number="5.3.1.6" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15755726, 15995210, 18640127, 19446032" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15755726, 15995210, 18640127, 19446032; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-ribose 5-phosphate epimerase (promiscuous)" /protein_id="NP_391573.1" /db_xref="EnsemblGenomes-Gn:BSU36920" /db_xref="EnsemblGenomes-Tr:CAB15709" /db_xref="GOA:P39156" /db_xref="InterPro:IPR003500" /db_xref="InterPro:IPR004785" /db_xref="InterPro:IPR036569" /db_xref="SubtiList:BG10942" /db_xref="UniProtKB/Swiss-Prot:P39156" /translation="MKVAIASDHGGVHIRNEIKELMDELQIEYIDMGCDCGSGSVDYP DYAFPVAEKVVSGEVDRGILICGTGIGMSISANKVKGIRCALAHDTFSAKATREHNDT NILAMGERVIGPGLAREIAKIWLTTEFTGGRHQTRIGKISDYEEKNL*" /label="rpiB CDS" gene complement(3415523..3415972) /gene="rpiB" /locus_tag="BSU_36920" /old_locus_tag="BSU36920" /label="rpiB gene" S_feature complement(3415973..3416072) /Source="Nicolas_S_feature" /locus_tag="new_3791649_3791748_c" /HighExp="Diami, dia5, C90, dia15, LPhT, M40t45, LBGtran, Lbtran, T-0.40H, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.68276199999999998" /TUshortSig="SigA, SigA" /TUshortPSig="0.96, 1" /TUlongSig="SigEF" /TUlongPSig="0.999" /label="S1429" promotor_-10 complement(3416064..3416083) /Source="Nicolas_upshift_promotors" /id="U2902" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.763236763236763" /psig="0.96003996003996" /xcortree=1986 /SigmaFactorBS="ataagttgtcagaaaatctgcaaacaggTCATTTGCaaatcc tgcgtgaAGGAGTAGAATATAGTGAAAagcacatcatatggtgtgaatcaaagagcgg a" /listShort="S1429, ywlF, ywlG, S1428, glyA" /listLong="upp, S1427, S1426, atpI" /label="promotor_-10" upshifts complement(3416072) /Source="Nicolas_upshifts" /id="U2902" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.763236763236763" /psig="0.96003996003996" /xcortree=1986 /SigmaFactorBS="ataagttgtcagaaaatctgcaaacaggTCATTTGCaaatcc tgcgtgaAGGAGTAGAATATAGTGAAAagcacatcatatggtgtgaatcaaagagcgg a" /listShort="S1429, ywlF, ywlG, S1428, glyA" /listLong="upp, S1427, S1426, atpI" /label="upshifts" promotor_-35 complement(3416097..3416104) /Source="Nicolas_upshift_promotors" /id="U2902" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.763236763236763" /psig="0.96003996003996" /xcortree=1986 /SigmaFactorBS="ataagttgtcagaaaatctgcaaacaggTCATTTGCaaatcc tgcgtgaAGGAGTAGAATATAGTGAAAagcacatcatatggtgtgaatcaaagagcgg a" /listShort="S1429, ywlF, ywlG, S1428, glyA" /listLong="upp, S1427, S1426, atpI" /label="promotor_-35" CDS complement(3416129..3416581) /gene="prpB" /locus_tag="BSU_36930" /old_locus_tag="BSU36930" /EC_number="3.9.1.2" /EC_number="3.1.3.48" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15995210, 22517742, 24825175, 25610436, 27524296" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15995210, 22517742, 24825175, 25610436, 27524296; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein-arginine(tyrosine moonlighting) phosphatase (oxidative stress)" /protein_id="NP_391574.1" /db_xref="EnsemblGenomes-Gn:BSU36930" /db_xref="EnsemblGenomes-Tr:CAB15710" /db_xref="GOA:P39155" /db_xref="InterPro:IPR017867" /db_xref="InterPro:IPR023485" /db_xref="InterPro:IPR036196" /db_xref="PDB:1ZGG" /db_xref="PDB:4ETI" /db_xref="PDB:4ETN" /db_xref="PDB:4KK3" /db_xref="PDB:4KK4" /db_xref="SubtiList:BG10941" /db_xref="UniProtKB/Swiss-Prot:P39155" /translation="MDIIFVCTGNTCRSPMAEALFKSIAEREGLNVNVRSAGVFASPN GKATPHAVEALFEKHIALNHVSSPLTEELMESADLVLAMTHQHKQIIASQFGRYRDKV FTLKEYVTGSHGDVLDPFGGSIDIYKQTRDELEELLRQLAKQLKKDRR*" /label="prpB CDS" gene complement(3416129..3416581) /gene="prpB" /locus_tag="BSU_36930" /old_locus_tag="BSU36930" /label="prpB gene" promotor_-10 complement(3416598..3416617) /Source="Nicolas_upshift_promotors" /id="U2903" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=1892 /SigmaFactorBS="agctgcttttgccaatttaatataccaataaaagaaacgaaG TCGccgtttcttttttcTTCATATATAATAGAGAAAAataaggggtgactgacatgga t" /listShort="ywlE, S1429, ywlF, ywlG, S1428, glyA" /listLong="upp" /label="promotor_-10" upshifts complement(3416616) /Source="Nicolas_upshifts" /id="U2903" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=1892 /SigmaFactorBS="agctgcttttgccaatttaatataccaataaaagaaacgaaG TCGccgtttcttttttcTTCATATATAATAGAGAAAAataaggggtgactgacatgga t" /listShort="ywlE, S1429, ywlF, ywlG, S1428, glyA" /listLong="upp" /label="upshifts" promotor_-35 complement(3416632..3416635) /Source="Nicolas_upshift_promotors" /id="U2903" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=1892 /SigmaFactorBS="agctgcttttgccaatttaatataccaataaaagaaacgaaG TCGccgtttcttttttcTTCATATATAATAGAGAAAAataaggggtgactgacatgga t" /listShort="ywlE, S1429, ywlF, ywlG, S1428, glyA" /listLong="upp" /label="promotor_-35" CDS complement(3416657..3417214) /gene="mntP" /locus_tag="BSU_36940" /old_locus_tag="BSU36940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16850406, 25774656, 25794618, 26076491; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="manganese efflux pump" /protein_id="NP_391575.1" /db_xref="EnsemblGenomes-Gn:BSU36940" /db_xref="EnsemblGenomes-Tr:CAB15711" /db_xref="GOA:P39154" /db_xref="InterPro:IPR003810" /db_xref="InterPro:IPR022929" /db_xref="SubtiList:BG10940" /db_xref="UniProtKB/Swiss-Prot:P39154" /translation="MSDLFIGELITLSIMAFALGMDAFSVGLGMGMVKLRKKQIFYIG FIIGLFHVIMPLAGMAAGNMLSGLLGVLAVYIGGALLFVLGVQMLMASFKQSEERFMS PAGPGLLLFAIGVSLDSFSVGLSLGIYGSHPLLTITLFGLFSMMLTWLGLLVGKQVQS WLGTYSEALGGIILIVFGLKLLLPI*" /label="mntP CDS" gene complement(3416657..3417214) /gene="mntP" /locus_tag="BSU_36940" /old_locus_tag="BSU36940" /label="mntP gene" promotor_-10 complement(3417241..3417259) /Source="Nicolas_upshift_promotors" /id="U2904" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=998 /SigmaFactorBS="cggaggaagagtgattcgctgaaagcagtcagatGTTCTAac cctttttggacacGCATAGGCTAAAAAAGCGGggcgtgtccaagggggttatttatgt a" /listShort="ywlD, ywlE" /listLong="S1429, ywlF, ywlG, S1428, glyA" /label="promotor_-10" upshifts complement(3417254) /Source="Nicolas_upshifts" /id="U2904" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=998 /SigmaFactorBS="cggaggaagagtgattcgctgaaagcagtcagatGTTCTAac cctttttggacacGCATAGGCTAAAAAAGCGGggcgtgtccaagggggttatttatgt a" /listShort="ywlD, ywlE" /listLong="S1429, ywlF, ywlG, S1428, glyA" /label="upshifts" promotor_-35 complement(3417275..3417280) /Source="Nicolas_upshift_promotors" /id="U2904" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=998 /SigmaFactorBS="cggaggaagagtgattcgctgaaagcagtcagatGTTCTAac cctttttggacacGCATAGGCTAAAAAAGCGGggcgtgtccaagggggttatttatgt a" /listShort="ywlD, ywlE" /listLong="S1429, ywlF, ywlG, S1428, glyA" /label="promotor_-35" CDS complement(3417293..3418333) /gene="tsaC" /locus_tag="BSU_36950" /old_locus_tag="BSU36950" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12682299, 16014871, 16890019, 17005971, 19884342, 20606270, 21775474, 19376873, 19578062, 20701780, 20824107, 21183954, 21285948, 22378793, 23072323, 27913733" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16014871, 16890019, 17005971, 19884342, 20606270, 21775474, 19376873, 19578062, 20701780, 20824107, 21183954, 21285948, 22378793, 23072323, 27913733; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="tRNA(NNU) t(6)A37 threonylcarbamoyladenosine modification; threonine-dependent ADP-forming ATPase" /protein_id="NP_391576.1" /db_xref="EnsemblGenomes-Gn:BSU36950" /db_xref="EnsemblGenomes-Tr:CAB15712" /db_xref="GOA:P39153" /db_xref="InterPro:IPR005145" /db_xref="InterPro:IPR006070" /db_xref="InterPro:IPR010923" /db_xref="InterPro:IPR017945" /db_xref="SubtiList:BG10939" /db_xref="UniProtKB/Swiss-Prot:P39153" /translation="MKTKRWFVDVTDELSTNDPQIAQAAALLRENEVVAFPTETVYGL GANAKNTDAVKKIYEAKGRPSDNPLIVHIADISQLEDLTGPAPEKAKTLMKRFWPGAL TLILPCKPDALSPRVTAGLETVAIRMPDHPLALALIRESGLPIAAPSANLSGKPSPTK AEHVAHDLDGRIAGIVDGGPTGIGVESTVLSCADDIPVLLRPGGITKEQIEAVIGPIH VDKGLSDQNEKPISPGMKYTHYAPTAPLAICEGSPERIQHLIQEYQQGGRRVGVLTTE EKAGVYSADYVKSCGRRAQLETVAAGLYDALRSFDENKVDFIIAESFPDTGVGLAIMN RLMKAAGGRVIR*" /label="tsaC CDS" gene complement(3417293..3418333) /gene="tsaC" /locus_tag="BSU_36950" /old_locus_tag="BSU36950" /label="tsaC gene" downshifts complement(3417298) /Source="Nicolas_upshifts" /id="D1910" /incds=0 /nref=4 /ntot=166 /MaxReadThrough="2.08557" /MaxDrop="2.98653" /score="-6.24994287" /energy="-9.8" /TU="NA" /idTUdmin="U2905" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3418334..3418398) /Source="Nicolas_S_feature" /locus_tag="new_3794010_3794074_c" /HighExp="dia15, Diami, C90, LBGstat, Heat, LBGtran, dia5, LBGexp, Lbexp, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="0.999, 0.444" /TUlongSig="NA" /TUlongPSig="NA" /label="S1430" promotor_-10 complement(3418388..3418407) /Source="Nicolas_upshift_promotors" /id="U2905" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.943056943056943" /psig="0.999000999001" /xcortree=2661 /SigmaFactorBS="ttattagcgttgtccacaatttgtggataacGCTTGttttat tacaggacaTCTTTTATACTTTCAAAAGGattacacgcgtaaaacaatcgttttattg t" /listShort="S1430, ywlC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3418398) /Source="Nicolas_upshifts" /id="U2905" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.943056943056943" /psig="0.999000999001" /xcortree=2661 /SigmaFactorBS="ttattagcgttgtccacaatttgtggataacGCTTGttttat tacaggacaTCTTTTATACTTTCAAAAGGattacacgcgtaaaacaatcgttttattg t" /listShort="S1430, ywlC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3418400..3418489) /Source="Nicolas_S_feature" /locus_tag="new_3794076_3794165_c" /HighExp="S3, M9-stat, Etha, LoTm, T5.0H, S7, S8, S4, BT, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.444" /TUlongSig="NA" /TUlongPSig="NA" /label="S1431" promotor_-35 complement(3418423..3418427) /Source="Nicolas_upshift_promotors" /id="U2905" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.943056943056943" /psig="0.999000999001" /xcortree=2661 /SigmaFactorBS="ttattagcgttgtccacaatttgtggataacGCTTGttttat tacaggacaTCTTTTATACTTTCAAAAGGattacacgcgtaaaacaatcgttttattg t" /listShort="S1430, ywlC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3418490..3418933) /gene="ywlB" /locus_tag="BSU_36960" /old_locus_tag="BSU36960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391577.1" /db_xref="EnsemblGenomes-Gn:BSU36960" /db_xref="EnsemblGenomes-Tr:CAB15713" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG10938" /db_xref="UniProtKB/Swiss-Prot:P39152" /translation="MFYQLRVAREKDGDVLEAFLKQAKTSYEGVKEGFTQFLMLEDSE KNIAGCLGIEKISCDQGLLRSLVISDKLHQGHIVTLFQSMEVLCEKHQIKTVYLVANQ HSSADFLTAMGFERAESVPEELFSSDHFCESRQTEGAVLMKKASG*" /label="ywlB CDS" gene complement(3418490..3418933) /gene="ywlB" /locus_tag="BSU_36960" /old_locus_tag="BSU36960" /label="ywlB gene" CDS complement(3419000..3419674) /gene="spoIIR" /locus_tag="BSU_36970" /old_locus_tag="BSU36970" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15044948, 16824103, 18378688, 20802044, 22111992" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15044948, 16824103, 18378688, 20802044, 22111992; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator signal of pro-sigma(E) spoIIGA endopeptidase (stage II sporulation)" /protein_id="NP_391578.1" /db_xref="EnsemblGenomes-Gn:BSU36970" /db_xref="EnsemblGenomes-Tr:CAB15714" /db_xref="GOA:P39151" /db_xref="InterPro:IPR014202" /db_xref="SubtiList:BG10937" /db_xref="UniProtKB/Swiss-Prot:P39151" /translation="MKKTVIICIYIFLLLSGALVGLAKEETAQKSENQPVVIPDQAIR LRILANSDSDQDQQLKRHIRDAVNKEITTWVKDITSIEEARRVIRSKLPEIKAIAKET MEKEGANQSISVDFDKISFPTKLYGNMVYPAGEYEAILITLGNGDGANWWCVLFPPLC FLDFSNGEAVKEQEDKEASKKQTEKVLEDVTAKAEKAKKEENEEKEDGTEVKFFLVEW ISDLFS*" /label="spoIIR CDS" gene complement(3419000..3419674) /gene="spoIIR" /locus_tag="BSU_36970" /old_locus_tag="BSU36970" /label="spoIIR gene" promotor_-10 complement(3419436..3419454) /Source="Nicolas_upshift_promotors" /id="U2906" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=243 /SigmaFactorBS="caattaaaacgtcatataagagacgcggTGAATAAagaaatc acaacttGGGTAAAGGATATTACTTCtattgaagaagcgcgtcgcgtgattcgttcaa a" /listShort="ywlB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3419443) /Source="Nicolas_upshifts" /id="U2906" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=243 /SigmaFactorBS="caattaaaacgtcatataagagacgcggTGAATAAagaaatc acaacttGGGTAAAGGATATTACTTCtattgaagaagcgcgtcgcgtgattcgttcaa a" /listShort="ywlB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3419469..3419475) /Source="Nicolas_upshift_promotors" /id="U2906" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=243 /SigmaFactorBS="caattaaaacgtcatataagagacgcggTGAATAAagaaatc acaacttGGGTAAAGGATATTACTTCtattgaagaagcgcgtcgcgtgattcgttcaa a" /listShort="ywlB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3419706..3419723) /Source="Nicolas_upshift_promotors" /id="U2907" /multdbtbs="SigF" /comp="M3" /sig="Sig-" /pcomp="0.443556443556444" /psig="0.443556443556444" /xcortree=964 /SigmaFactorBS="tgctagatttttttcaccctgcaCGTTTAtcccaggctctcc ttGTCCATAATAGGGCTAGAaacaaagcacggagaggaacggtggggaccgatgaaaa a" /listShort="spoIIR, ywlB, S1431, S1430, ywlC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3419707) /Source="Nicolas_upshifts" /id="U2907" /multdbtbs="SigF" /comp="M3" /sig="Sig-" /pcomp="0.443556443556444" /psig="0.443556443556444" /xcortree=964 /SigmaFactorBS="tgctagatttttttcaccctgcaCGTTTAtcccaggctctcc ttGTCCATAATAGGGCTAGAaacaaagcacggagaggaacggtggggaccgatgaaaa a" /listShort="spoIIR, ywlB, S1431, S1430, ywlC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3419739..3419744) /Source="Nicolas_upshift_promotors" /id="U2907" /multdbtbs="SigF" /comp="M3" /sig="Sig-" /pcomp="0.443556443556444" /psig="0.443556443556444" /xcortree=964 /SigmaFactorBS="tgctagatttttttcaccctgcaCGTTTAtcccaggctctcc ttGTCCATAATAGGGCTAGAaacaaagcacggagaggaacggtggggaccgatgaaaa a" /listShort="spoIIR, ywlB, S1431, S1430, ywlC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3419780 /Source="Nicolas_upshifts" /id="U2908" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2167 /SigmaFactorBS="ggacaaggagagcctgggataaacgtgcagggtgaaaaaaat ctagcaagctgttaatcttattTATGGTACGATAGTGTTTTAggaggtttaagatgaa a" /listShort="ywlA" /GFF_Attribute="listLong" /label="upshifts" misc_feature 3419784..3419803 /Source="Nicolas_upshift_promotors" /id="U2908" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2167 /SigmaFactorBS="ggacaaggagagcctgggataaacgtgcagggtgaaaaaaat ctagcaagctgttaatcttattTATGGTACGATAGTGTTTTAggaggtttaagatgaa a" /listShort="ywlA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 3419815..3420177 /gene="ywlA" /locus_tag="BSU_36980" /old_locus_tag="BSU36980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391579.1" /db_xref="EnsemblGenomes-Gn:BSU36980" /db_xref="EnsemblGenomes-Tr:CAB15715" /db_xref="GOA:P39150" /db_xref="InterPro:IPR031374" /db_xref="SubtiList:BG10936" /db_xref="UniProtKB/Swiss-Prot:P39150" /translation="MKYNYTVLLSAFTMSVLYSVIYIHSFIIAALITMAFYFLFPYLI FALPLQIMMNKKPKRFSPLYLLYYLAAAFIANAIIFGMLQPSGQSLFQNTAFYLFAVL TALIYWIWDSVLLQKKEA*" /label="ywlA CDS" gene 3419815..3420177 /gene="ywlA" /locus_tag="BSU_36980" /old_locus_tag="BSU36980" /label="ywlA gene" downshifts complement(3420190) /Source="Nicolas_upshifts" /id="D1911" /incds=0 /nref=27 /ntot=242 /MaxReadThrough="2.64328" /MaxDrop="5.72616" /score="26.8558862" /energy="-11.3" /TU="U2910" /idTUdmin="U2909" /TUdmin=12 /isTUend="TRUE" /label="downshifts" CDS complement(3420194..3420481) /gene="ywkF" /locus_tag="BSU_36990" /old_locus_tag="BSU36990" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391580.1" /db_xref="EnsemblGenomes-Gn:BSU36990" /db_xref="EnsemblGenomes-Tr:CAB15716" /db_xref="GOA:P45874" /db_xref="InterPro:IPR035167" /db_xref="SubtiList:BG11317" /db_xref="UniProtKB/Swiss-Prot:P45874" /translation="MKKALTAGILLIAIESMIGTIFPQALSYEAIFGVASLVLVGLAI ITSGLAVSGSDQRANYHSETKEGRTSRMKMAAAFFVAAIPSILCYLLTILF*" /label="ywkF CDS" gene complement(3420194..3420481) /gene="ywkF" /locus_tag="BSU_36990" /old_locus_tag="BSU36990" /label="ywkF gene" S_feature complement(3420482..3420540) /Source="Nicolas_S_feature" /locus_tag="new_3796158_3796216_c" /HighExp="S6, S8, S7, BT, G135, G180, Paraq, H2O2, G150, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA" /TUshortPSig="1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1432" promotor_-10 complement(3420538..3420557) /Source="Nicolas_upshift_promotors" /id="U2909" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1326 /SigmaFactorBS="cggaagtggaagtgctgaaagatattaatggaaaaGACAGAA CCAtatgcgctctgaTTCATAAAAATAAATAAGCAgcttgctggcgagtgaatggatc a" /listShort="S1432, ywkF" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(3420541..3421407) /gene="prmC" /locus_tag="BSU_37000" /old_locus_tag="BSU37000" /EC_number="2.1.1.297" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16014871, 16364916, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamine methylase of release factor 1 (and perhaps others) at a GGQ site" /protein_id="NP_391581.1" /db_xref="EnsemblGenomes-Gn:BSU37000" /db_xref="EnsemblGenomes-Tr:CAB15717" /db_xref="GOA:P45873" /db_xref="InterPro:IPR002052" /db_xref="InterPro:IPR004556" /db_xref="InterPro:IPR007848" /db_xref="InterPro:IPR019874" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11316" /db_xref="UniProtKB/Swiss-Prot:P45873" /translation="MKTIFEALKWASSYLTEAGREENAAELLLLYDTGMERSKLLASL QEPIGEDELYRFKRHVEMHKEGVPVQYIIGKEFFYGREFMVNDDVLIPRPETEEVVFH LLEKYRSVFSEDGKLEVVDVGTGSGAIAVTLALENQSFSVSAVDISKEALQVASANAE KLGANVRFYQGDLLEPFIKAGKKADIIVSNPPYISEEEMADLSEIVRFHEPLHALTDG GDGLKFYKRFMEDIPLVMKDKVFVVFEIGWKQGAAVKDLILKAFKGAEVEVLKDINGK DRTICALIHKNK*" /label="prmC CDS" gene complement(3420541..3421407) /gene="prmC" /locus_tag="BSU_37000" /old_locus_tag="BSU37000" /label="prmC gene" upshifts complement(3420554) /Source="Nicolas_upshifts" /id="U2909" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1326 /SigmaFactorBS="cggaagtggaagtgctgaaagatattaatggaaaaGACAGAA CCAtatgcgctctgaTTCATAAAAATAAATAAGCAgcttgctggcgagtgaatggatc a" /listShort="S1432, ywkF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3420570..3420579) /Source="Nicolas_upshift_promotors" /id="U2909" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1326 /SigmaFactorBS="cggaagtggaagtgctgaaagatattaatggaaaaGACAGAA CCAtatgcgctctgaTTCATAAAAATAAATAAGCAgcttgctggcgagtgaatggatc a" /listShort="S1432, ywkF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3421409..3422479) /gene="prfA" /locus_tag="BSU_37010" /old_locus_tag="BSU37010" /experiment="publication(s) with functional evidences, PMID:2186375, 1408743, 10446248, 12237459, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2186375, 1408743, 10446248, 12237459, 12682299; Product type f: factor" /codon_start=1 /transl_table=11 /product="peptide chain release factor 1" /protein_id="NP_391582.1" /db_xref="EnsemblGenomes-Gn:BSU37010" /db_xref="EnsemblGenomes-Tr:CAB15718" /db_xref="GOA:P45872" /db_xref="InterPro:IPR000352" /db_xref="InterPro:IPR004373" /db_xref="InterPro:IPR005139" /db_xref="SubtiList:BG11244" /db_xref="UniProtKB/Swiss-Prot:P45872" /translation="MLDRLKSIEERYEKLNELLSDPEVVNDPKKLREYSKEQSDIQET VDVYRQYRDASEQLADAKAMLEEKLDAEMRDMVKEEISELQKETETLSERLKVLLIPK DPNDDKNVIMEIRGAAGGEEAALFAGNLYRMYSRYAELQGWKTEVMEANVTGTGGYKE IIFMITGSGAYSKLKYENGAHRVQRVPETESGGRIHTSTATVACLPEAEEVEVDIHEK DIRVDTFASSGPGGQSVNTTMSAVRLTHLPTGVVVSCQDEKSQIKNKEKAMKVLRARI YDKFQQEAQAEYDQTRKSAVGSGDRSERIRTYNFPQNRVTDHRIGLTIQKLDQILEGK LDEVVEALIVEDQASKLQQSEG*" /label="prfA CDS" gene complement(3421409..3422479) /gene="prfA" /locus_tag="BSU_37010" /old_locus_tag="BSU37010" /label="prfA gene" downshifts complement(3421412) /Source="Nicolas_upshifts" /id="D1912" /incds=0 /nref=23 /ntot=212 /MaxReadThrough="5.17118" /MaxDrop="3.44681" /score="-9.55295942" /energy="-10.5" /TU="U2910" /idTUdmin="U2912" /TUdmin=1122 /isTUend="FALSE" /label="downshifts" downshifts 3422480 /Source="Nicolas_upshifts" /id="D1913" /incds=0 /nref=1 /ntot=68 /MaxReadThrough="1.13519" /MaxDrop="4.28706" /score="36.3991981" /energy="-10.4" /TU="NA" /idTUdmin="U2911" /TUdmin="-990" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3422507..3422526) /Source="Nicolas_upshift_promotors" /id="U2910" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig="0.998001998001998" /xcortree=2501 /SigmaFactorBS="attccagtatagcagagggagcttttccagctgggattgaaa tgcTTTTGACtggggttaatcacTATACTATAATGAGAATGTTacgcacaggaaaaca g" /listShort="prfA, prmC, S1432, ywkF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3422531) /Source="Nicolas_upshifts" /id="U2910" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig="0.998001998001998" /xcortree=2501 /SigmaFactorBS="attccagtatagcagagggagcttttccagctgggattgaaa tgcTTTTGACtggggttaatcacTATACTATAATGAGAATGTTacgcacaggaaaaca g" /listShort="prfA, prmC, S1432, ywkF" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3422533..3422644) /Source="Nicolas_S_feature" /locus_tag="new_3798209_3798320_c" /HighExp="S6, S8, S7, BT, S5, Etha, B36, C30, S4, GM 25" /AntisenseName="ywkD" /AntisenseCor="-0.43140174721346802" /AntisenseRegPval="-12.9" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.927" /TUlongSig="NA" /TUlongPSig="NA" /label="S1433" promotor_-35 complement(3422540..3422546) /Source="Nicolas_upshift_promotors" /id="U2910" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig="0.998001998001998" /xcortree=2501 /SigmaFactorBS="attccagtatagcagagggagcttttccagctgggattgaaa tgcTTTTGACtggggttaatcacTATACTATAATGAGAATGTTacgcacaggaaaaca g" /listShort="prfA, prmC, S1432, ywkF" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 3422576..3422595 /Source="Nicolas_upshift_promotors" /id="U2911" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.561438561438561" /psig="0.99100899100899" /xcortree=2343 /SigmaFactorBS="attaaccccagtcaaaagcatttcaatcccagctggaaaagc tcccTCTGCTATACTGGAATTCGAggagggatgatgttgctgaaatccatacatcata t" /listShort="ywkD, racA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3422590 /Source="Nicolas_upshifts" /id="U2911" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.561438561438561" /psig="0.99100899100899" /xcortree=2343 /SigmaFactorBS="attaaccccagtcaaaagcatttcaatcccagctggaaaagc tcccTCTGCTATACTGGAATTCGAggagggatgatgttgctgaaatccatacatcata t" /listShort="ywkD, racA" /GFF_Attribute="listLong" /label="upshifts" CDS 3422605..3422991 /gene="ywkD" /locus_tag="BSU_37020" /old_locus_tag="BSU37020" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_391583.1" /db_xref="EnsemblGenomes-Gn:BSU37020" /db_xref="EnsemblGenomes-Tr:CAB15719" /db_xref="GOA:P45871" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG11315" /db_xref="UniProtKB/Swiss-Prot:P45871" /translation="MLLKSIHHIAIICSDYEKSKAFYVHKLGFQVIQETYREERGSYK LDLSLNGSYVIELFSFPDPPERQTRPEAAGLRHLAFTVGSLDKAVQELHEKGIETEPI RTDPLTGKRFTFFFDPDQLPLELYEQ*" /label="ywkD CDS" gene 3422605..3422991 /gene="ywkD" /locus_tag="BSU_37020" /old_locus_tag="BSU37020" /label="ywkD gene" promotor_-10 complement(3422626..3422644) /Source="Nicolas_upshift_promotors" /id="U2912" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.927072927072927" /psig="0.927072927072927" /xcortree=1264 /SigmaFactorBS="cttgaatcacctgaaaaccaagcttatgtacgtagaaagCTT TCGACttttcgtaatctgAACATATGATTGCAATATGatgtatggatttcagcaacat c" /listShort="S1433" /listLong="prfA" /label="promotor_-10" upshifts complement(3422644) /Source="Nicolas_upshifts" /id="U2912" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.927072927072927" /psig="0.927072927072927" /xcortree=1264 /SigmaFactorBS="cttgaatcacctgaaaaccaagcttatgtacgtagaaagCTT TCGACttttcgtaatctgAACATATGATTGCAATATGatgtatggatttcagcaacat c" /listShort="S1433" /listLong="prfA" /label="upshifts" promotor_-35 complement(3422658..3422665) /Source="Nicolas_upshift_promotors" /id="U2912" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.927072927072927" /psig="0.927072927072927" /xcortree=1264 /SigmaFactorBS="cttgaatcacctgaaaaccaagcttatgtacgtagaaagCTT TCGACttttcgtaatctgAACATATGATTGCAATATGatgtatggatttcagcaacat c" /listShort="S1433" /listLong="prfA" /label="promotor_-35" promotor_-35 3423059..3423067 /Source="Nicolas_upshift_promotors" /id="U2913" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=449 /SigmaFactorBS="ccactttctttgccgaatcttttcttgttttgtctaacggGA AGGGAACcgcattctatGGTCGAATACCTAGCTTAAaaggaggtatgggatcatgaat a" /listShort="racA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3423078..3423096 /Source="Nicolas_upshift_promotors" /id="U2913" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=449 /SigmaFactorBS="ccactttctttgccgaatcttttcttgttttgtctaacggGA AGGGAACcgcattctatGGTCGAATACCTAGCTTAAaaggaggtatgggatcatgaat a" /listShort="racA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3423079 /Source="Nicolas_upshifts" /id="U2913" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=449 /SigmaFactorBS="ccactttctttgccgaatcttttcttgttttgtctaacggGA AGGGAACcgcattctatGGTCGAATACCTAGCTTAAaaggaggtatgggatcatgaat a" /listShort="racA" /GFF_Attribute="listLong" /label="upshifts" CDS 3423113..3423667 /gene="racA" /locus_tag="BSU_37030" /old_locus_tag="BSU37030" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15780934, 17139259, 19478798, 22720735, 27059541, 27085804" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15780934, 17139259, 19478798, 22720735, 27059541, 27085804; Product type f : factor" /codon_start=1 /transl_table=11 /product="chromosome-pole-anchoring protein RacA" /protein_id="NP_391584.1" /db_xref="EnsemblGenomes-Gn:BSU37030" /db_xref="EnsemblGenomes-Tr:CAB15720" /db_xref="GOA:P45870" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="InterPro:IPR023522" /db_xref="PDB:5I41" /db_xref="PDB:5I44" /db_xref="SubtiList:BG11314" /db_xref="UniProtKB/Swiss-Prot:P45870" /translation="MNTNMVASELGVSAKTVQRWVKQLNLPAERNELGHYSFTAEDVK VLKSVQKQISEGTAIQDIHLPKSAKKRTGFLVQKTSSDTERRIEQLEQKLDTLLQQRQ DESELMARMSELERQLKQKADEGVSYQLLQHRREIDDILADLQSLTSQMKEFTAHSIP ETAAASEKTKTRKKPLLSLFKFQT*" /label="racA CDS" gene 3423113..3423667 /gene="racA" /locus_tag="BSU_37030" /old_locus_tag="BSU37030" /label="racA gene" misc_feature 3423597..3423601 /Source="Nicolas_upshift_promotors" /id="U2914" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.747252747252747" /psig="0.015984015984016" /xcortree=450 /SigmaFactorBS="ctgcaatcactgacctcacaaatgaaagaattcaccgctcat tcgatccccgagaCTGCTgctgcttctgaaaaaaccaaaacaagaaaaaaaccgctgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3423602 /Source="Nicolas_upshifts" /id="U2914" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.747252747252747" /psig="0.015984015984016" /xcortree=450 /SigmaFactorBS="ctgcaatcactgacctcacaaatgaaagaattcaccgctcat tcgatccccgagaCTGCTgctgcttctgaaaaaaccaaaacaagaaaaaaaccgctgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 3423646 /Source="Nicolas_upshifts" /id="D1914" /incds=0 /nref=213 /ntot=274 /MaxReadThrough="0.82868" /MaxDrop="8.28021" /score="36.3991981" /energy="-10.4" /TU="U2913" /idTUdmin="U2914" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3423701..3424660) /gene="ywkB" /locus_tag="BSU_37040" /old_locus_tag="BSU37040" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12949160, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative metabolite transporter" /protein_id="NP_391585.1" /db_xref="EnsemblGenomes-Gn:BSU37040" /db_xref="EnsemblGenomes-Tr:CAB15721" /db_xref="GOA:P45869" /db_xref="InterPro:IPR004776" /db_xref="InterPro:IPR014024" /db_xref="SubtiList:BG11313" /db_xref="UniProtKB/Swiss-Prot:P45869" /translation="MSILDILILLAPIFFVIVLGWFAGHFGSYDAKSAKGVSTLVTKY ALPAHFIAGILTTSRSEFLSQVPLMISLIIGIVGFYIIILLVCRFIFKYDLTNSSVFS LNSAQPTFAFMGIPVLGSLFGANEVAIPIAVTGIVVNAILDPLAIIIATVGESSKKNE ESGDSFWKMTGKSILHGLCEPLAAAPLISMILVLVFNFTLPELGVKMLDQLGSTTSGV ALFAVGVTVGIRKIKLSMPAIGIALLKVAVQPALMFLIALAIGLPADQTTKAILLVAF PGSAVAAMIATRFEKQEEETATAFVVSAILSLISLPIIIALTA*" /label="ywkB CDS" gene complement(3423701..3424660) /gene="ywkB" /locus_tag="BSU_37040" /old_locus_tag="BSU37040" /label="ywkB gene" downshifts complement(3423723) /Source="Nicolas_upshifts" /id="D1915" /incds=0 /nref=36 /ntot=74 /MaxReadThrough="2.86006" /MaxDrop="4.78642" /score="20.048754" /energy="-10.4" /TU="U2916" /idTUdmin="U2917" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3424698..3424716) /Source="Nicolas_upshift_promotors" /id="U2915" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=735 /SigmaFactorBS="acctgaatacaaaaaagtcatcgcgaaataattagCGAGTAA atttttctgtccgaGGGAAAGCTTTTTGTAAAGctaaagtatacggacataggatttg g" /listShort="ywkB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3424712) /Source="Nicolas_upshifts" /id="U2915" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=735 /SigmaFactorBS="acctgaatacaaaaaagtcatcgcgaaataattagCGAGTAA atttttctgtccgaGGGAAAGCTTTTTGTAAAGctaaagtatacggacataggatttg g" /listShort="ywkB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3424731..3424737) /Source="Nicolas_upshift_promotors" /id="U2915" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=735 /SigmaFactorBS="acctgaatacaaaaaagtcatcgcgaaataattagCGAGTAA atttttctgtccgaGGGAAAGCTTTTTGTAAAGctaaagtatacggacataggatttg g" /listShort="ywkB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3424742..3426490) /gene="maeA" /locus_tag="BSU_37050" /old_locus_tag="BSU37050" /EC_number="1.1.1.38" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12949160, 16788182, 20933603, 22740702, 23136871, 24325460" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12949160, 16788182, 20933603, 22740702, 23136871, 24325460; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="NAD-dependent malic enzyme (conversion of malateinto pyruvate)" /protein_id="NP_391586.1" /db_xref="EnsemblGenomes-Gn:BSU37050" /db_xref="EnsemblGenomes-Tr:CAB15722" /db_xref="GOA:P45868" /db_xref="InterPro:IPR001891" /db_xref="InterPro:IPR012301" /db_xref="InterPro:IPR012302" /db_xref="InterPro:IPR015884" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR037062" /db_xref="SubtiList:BG11312" /db_xref="UniProtKB/Swiss-Prot:P45868" /translation="MGYYLTWLTISRKKEICLNNIKKTKEGHLETTLRGKEVLSIPTL NKGVAFSLEERQELGLEGLLPPTVLSLDQQAQRAYEQFQAQPDRLRQNVYLSDLANRN EVLFYKLLKNHLREMLPVVYTPTVGEAIQEYSHEYRRPQGIYLSIDNIDGIEKAFENL HATAGDIDLIVATDSESILGIGDWGVGGINIAIGKLAVYTAAAGIDPSRVIPVVLDVG TNNEKLLNDPLYIGNKHERVQGERYEAFIDAYVKAALKFFPKALLHWEDLGNKNARNI MKKYNHEILTFNDDIQGTGAITLAGVLAAMKKTGASIKDQRVVIFGAGSAGIGIADQI RDTMVLAGLSEEEANKRFYTLDYRGLLTEDIEGILDFQKPYLRNADEVKDWKRDEKGQ IPFDEVVRQAKPTILIGTSGVSGAFTEEIVKEMASHVDRPVIMPMSNPTHLAEAVPED LFKWTDGKVLIATGSPFDNVEYNGVSYEIGQSNNAFAFPGLGLGSIVAEARIITPAMF AATADAIAEMVDLETPGAGLLPSIDKLQEVSIQVAIAVAEAAIKDGVANRQPEDVKQA VLDAMWTPEYKKVIAK*" /label="maeA CDS" gene complement(3424742..3426490) /gene="maeA" /locus_tag="BSU_37050" /old_locus_tag="BSU37050" /label="maeA gene" promotor_-10 complement(3425216..3425234) /Source="Nicolas_upshift_promotors" /id="U2916" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=177 /SigmaFactorBS="aaaccaacaatcttgattggtacttcaggGGTTTCAggtgca ttcacagaGGAAATTGTAAAAGAAATGgcatctcacgtagaccgtccggttatcatgc c" /listShort="ywkB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3425224) /Source="Nicolas_upshifts" /id="U2916" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=177 /SigmaFactorBS="aaaccaacaatcttgattggtacttcaggGGTTTCAggtgca ttcacagaGGAAATTGTAAAAGAAATGgcatctcacgtagaccgtccggttatcatgc c" /listShort="ywkB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3425249..3425255) /Source="Nicolas_upshift_promotors" /id="U2916" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=177 /SigmaFactorBS="aaaccaacaatcttgattggtacttcaggGGTTTCAggtgca ttcacagaGGAAATTGTAAAAGAAATGgcatctcacgtagaccgtccggttatcatgc c" /listShort="ywkB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3426491..3426581) /Source="Nicolas_S_feature" /locus_tag="new_3802167_3802257_c" /HighExp="GM 25, GM 15, GM 60, GM 90, GM 120, MG-0.2, MG 15, GM 45, MG-0.1, GM 10" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1434" promotor_-10 complement(3426565..3426584) /Source="Nicolas_upshift_promotors" /id="U2917" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.731268731268731" /psig="0.999000999001" /xcortree=1757 /SigmaFactorBS="aaataagtatattaaaaaattaagtaattttcttctCTTGAA TTttgattttgacagGCATACAATAGCTTACGTAAtgtaaatagttttgagacattgt t" /listShort="S1434, maeA, ywkB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3426581) /Source="Nicolas_upshifts" /id="U2917" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.731268731268731" /psig="0.999000999001" /xcortree=1757 /SigmaFactorBS="aaataagtatattaaaaaattaagtaattttcttctCTTGAA TTttgattttgacagGCATACAATAGCTTACGTAAtgtaaatagttttgagacattgt t" /listShort="S1434, maeA, ywkB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3426598..3426605) /Source="Nicolas_upshift_promotors" /id="U2917" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.731268731268731" /psig="0.999000999001" /xcortree=1757 /SigmaFactorBS="aaataagtatattaaaaaattaagtaattttcttctCTTGAA TTttgattttgacagGCATACAATAGCTTACGTAAtgtaaatagttttgagacattgt t" /listShort="S1434, maeA, ywkB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3426724) /Source="Nicolas_upshifts" /id="D1916" /incds=0 /nref=11 /ntot=126 /MaxReadThrough="2.81368" /MaxDrop="3.39095" /score="20.3711149" /energy="-7.5" /TU="NA" /idTUdmin="U2918" /TUdmin="-10" /isTUend="TRUE" /label="downshifts" CDS complement(3426729..3427316) /gene="tdk" /locus_tag="BSU_37060" /old_locus_tag="BSU37060" /EC_number="2.7.1.21" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2423635, 17132103; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thymidine kinase" /protein_id="NP_391587.1" /db_xref="EnsemblGenomes-Gn:BSU37060" /db_xref="EnsemblGenomes-Tr:CAB15723" /db_xref="GOA:Q03221" /db_xref="InterPro:IPR001267" /db_xref="InterPro:IPR020633" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10419" /db_xref="UniProtKB/Swiss-Prot:Q03221" /translation="MYIMKQSGWLELICGSMFSGKSEELIRRVKRATYAKQEVRVFKP VIDNRYSEAAVVSHNGTSMTSYAISSAADIWDHISESTDVVAVDEVQFFDQEIVEVLS SLADKGYRVIAAGLDMDFRGEPFGVVPNIMAIAESVTKLQAVCSVCGSPASRTQRLID GKPASYDDPVILVGAAESYEARCRHHHEVPGKSKK*" /label="tdk CDS" gene complement(3426729..3427316) /gene="tdk" /locus_tag="BSU_37060" /old_locus_tag="BSU37060" /label="tdk gene" CDS complement(3427405..3427605) /gene="rpmEA" /locus_tag="BSU_37070" /old_locus_tag="BSU37070" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15049826, 16014871, 16547061, 17163968, 17310068, 19648245, 20208344, 27561249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15049826, 16014871, 16547061, 17163968, 17310068, 19648245, 20208344, 27561249; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L31" /protein_id="NP_391588.1" /db_xref="EnsemblGenomes-Gn:BSU37070" /db_xref="EnsemblGenomes-Tr:CAB15724" /db_xref="GOA:Q03223" /db_xref="InterPro:IPR002150" /db_xref="InterPro:IPR027491" /db_xref="InterPro:IPR034704" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10417" /db_xref="UniProtKB/Swiss-Prot:Q03223" /translation="MKAGIHPNFKKATVKCACGNEFETGSVKEEVRVEICSECHPFYT GRQKFASADGRVDRFNKKYGLK*" /label="rpmEA CDS" gene complement(3427405..3427605) /gene="rpmEA" /locus_tag="BSU_37070" /old_locus_tag="BSU37070" /label="rpmEA gene" downshifts complement(3427418) /Source="Nicolas_upshifts" /id="D1917" /incds=0 /nref=268 /ntot=279 /MaxReadThrough="5.35148" /MaxDrop="6.82076" /score="15.63162" /energy="-10.3" /TU="U2918,U2919" /idTUdmin="U2921" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3427606..3427683) /Source="Nicolas_S_feature" /locus_tag="new_3803282_3803359_c" /HighExp="HPh, LPh, LPhT, GM 45, Paraq, MG 45, MG 60, aero, LBGexp, MG 10" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.999, 0.811, 1" /TUlongSig="SigH, SigA" /TUlongPSig="1, 0.997" /label="S1435" promotor_-10 complement(3427679..3427698) /Source="Nicolas_upshift_promotors" /id="U2918" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.49050949050949" /psig="0.999000999001" /xcortree=2639 /SigmaFactorBS="tatcatctgcaagaaggtaaattgTATTTGCAaaagaagtaa atcACTGATATAATTTTCTCATAtgcgtttcggacaatgctccgaaataataactctg t" /listShort="S1435, rpmEA, tdk" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3427683) /Source="Nicolas_upshifts" /id="U2918" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.49050949050949" /psig="0.999000999001" /xcortree=2639 /SigmaFactorBS="tatcatctgcaagaaggtaaattgTATTTGCAaaagaagtaa atcACTGATATAATTTTCTCATAtgcgtttcggacaatgctccgaaataataactctg t" /listShort="S1435, rpmEA, tdk" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3427712..3427719) /Source="Nicolas_upshift_promotors" /id="U2918" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.49050949050949" /psig="0.999000999001" /xcortree=2639 /SigmaFactorBS="tatcatctgcaagaaggtaaattgTATTTGCAaaagaagtaa atcACTGATATAATTTTCTCATAtgcgtttcggacaatgctccgaaataataactctg t" /listShort="S1435, rpmEA, tdk" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3427724..3429007) /gene="rho" /locus_tag="BSU_37080" /old_locus_tag="BSU37080" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10027981, 16014871, 18852477, 28520932, 28723971" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10027981, 16014871, 18852477, 28520932, 28723971; Product type f: factor" /codon_start=1 /transl_table=11 /product="transcriptional terminator Rho" /protein_id="NP_391589.2" /db_xref="EnsemblGenomes-Gn:BSU37080" /db_xref="EnsemblGenomes-Tr:CAB15725" /db_xref="GOA:Q03222" /db_xref="InterPro:IPR000194" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004665" /db_xref="InterPro:IPR011112" /db_xref="InterPro:IPR011113" /db_xref="InterPro:IPR011129" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036269" /db_xref="SubtiList:BG10416" /db_xref="UniProtKB/Swiss-Prot:Q03222" /translation="MKDVSISSLENMKLKELYELARHYKISYYSKLTKKELIFAILKA NAEQEDLLFMEGVLEIIQSEGFGFLRPINYSPSSEDIYISASQIRRFDLRNGDKVSGK VRPPKENERYYGLLHVEAVNGDDPESAKERVHFPALTPLYPDRQMVLETKPNFLSTRI MDMMAPVGFGQRGLIVAPPKAGKTMLLKEIANSITANQPEAELIVLLIDERPEEVTDI ERSVAGDVVSSTFDEVPENHIKVAELVLERAMRLVEHKKDVIILMDSITRLARAYNLV IPPSGRTLSGGIDPAAFHRPKRFFGAARNIEEGGSLTILATALVDTGSRMDDVIYEEF KGTGNMELHLDRSLAERRIFPAIDIRRSGTRKEELLVPKEHLDRLWSIRKTMSDSPDF AEKFMRKMKKTKTNQEFFDILNQEWKQANLSSARR*" /label="rho CDS" gene complement(3427724..3429007) /gene="rho" /locus_tag="BSU_37080" /old_locus_tag="BSU37080" /label="rho gene" S_feature complement(3429008..3429310) /Source="Nicolas_S_feature" /locus_tag="new_3804684_3804986_c" /HighExp="H2O2, Cold, G135, HPh, G180, G150, LBGstat, Oxctl, Paraq, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.811, 1" /TUlongSig="SigH, SigA" /TUlongPSig="1, 0.997" /label="S1436" CDS complement(3429038..3429199) /locus_tag="BSU_37089" /old_locus_tag="BSU37089" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 20525796" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514010.1" /db_xref="EnsemblGenomes-Gn:BSU37089" /db_xref="EnsemblGenomes-Tr:CCQ48606" /db_xref="UniProtKB/TrEMBL:L8EA05" /translation="MFLSSLPSKLIKTILLTKAPIMGGSVTDRSSFMLKKECALADVV QKQQMTCSE*" /label="hypothetical protein CDS" gene complement(3429038..3429199) /locus_tag="BSU_37089" /old_locus_tag="BSU37089" /label="gene" promotor_-10 complement(3429290..3429309) /Source="Nicolas_upshift_promotors" /id="U2919" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.72027972027972" /psig="0.811188811188811" /xcortree=2485 /SigmaFactorBS="aaagcgtcaactctatcaattccgtgtcaaaaccttatttcA GTTGaataattttttgaaaTAAGGTAAAAATAAAGAGTGctgcgaattttactgcgta a" /listShort="S1436, rho, S1435, rpmEA, tdk" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3429310) /Source="Nicolas_upshifts" /id="U2919" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.72027972027972" /psig="0.811188811188811" /xcortree=2485 /SigmaFactorBS="aaagcgtcaactctatcaattccgtgtcaaaaccttatttcA GTTGaataattttttgaaaTAAGGTAAAAATAAAGAGTGctgcgaattttactgcgta a" /listShort="S1436, rho, S1435, rpmEA, tdk" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3429325..3429329) /Source="Nicolas_upshift_promotors" /id="U2919" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.72027972027972" /psig="0.811188811188811" /xcortree=2485 /SigmaFactorBS="aaagcgtcaactctatcaattccgtgtcaaaaccttatttcA GTTGaataattttttgaaaTAAGGTAAAAATAAAGAGTGctgcgaattttactgcgta a" /listShort="S1436, rho, S1435, rpmEA, tdk" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3429414..3430379) /gene="glpX" /locus_tag="BSU_37090" /old_locus_tag="BSU37090" /EC_number="3.1.3.11" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:19270101" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19270101; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fructose 1,6-bisphosphatase class II" /protein_id="NP_391590.1" /db_xref="EnsemblGenomes-Gn:BSU37090" /db_xref="EnsemblGenomes-Tr:CAB15726" /db_xref="GOA:Q03224" /db_xref="InterPro:IPR004464" /db_xref="SubtiList:BG10415" /db_xref="UniProtKB/Swiss-Prot:Q03224" /translation="MERSLSMELVRVTEAAALASARWMGRGKKDEADEAATSAMRDVF DTVPMKGTVVIGEGEMDEAPMLYIGEKLGNGYGPRVDVAVDPLEGTNILASGGWNALT VIAVADHGTLLNAPDMYMQKIAVGPEAVGCIDIEAPVIDNLKAVAKAKNKDVEDVVAT ILNRERHAKIISELREAGARIKLINDGDVAGAINTAFDHTGVDILFGSGGAPEGVLSA VALKALGGEIIGKLLPQSEEEITRCHKMGLDLSKVLRMEDLVKGDDAIFAATGVTDGE LLKGVQFKGSVGTTESLVIRAKSGTVRFVDGRHSLKKKPNLVIRP*" /label="glpX CDS" gene complement(3429414..3430379) /gene="glpX" /locus_tag="BSU_37090" /old_locus_tag="BSU37090" /label="glpX gene" downshifts complement(3429420) /Source="Nicolas_upshifts" /id="D1918" /incds=0 /nref=56 /ntot=196 /MaxReadThrough="5.42698" /MaxDrop="5.21817" /score="-2.15106481" /energy="-10.2" /TU="U2921,U2922" /idTUdmin="U2922" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" promotor_-35 3429996..3430005 /Source="Nicolas_upshift_promotors" /id="U2920" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1384 /SigmaFactorBS="aggtgcttcgatgtcaatgcagcccaccgcTTCCGGACCGac tgcgatttttTGCATATACATGTCAGGAGCattcagaagcgtgccatggtctgcgacc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3430018..3430037 /Source="Nicolas_upshift_promotors" /id="U2920" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1384 /SigmaFactorBS="aggtgcttcgatgtcaatgcagcccaccgcTTCCGGACCGac tgcgatttttTGCATATACATGTCAGGAGCattcagaagcgtgccatggtctgcgacc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3430026 /Source="Nicolas_upshifts" /id="U2920" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1384 /SigmaFactorBS="aggtgcttcgatgtcaatgcagcccaccgcTTCCGGACCGac tgcgatttttTGCATATACATGTCAGGAGCattcagaagcgtgccatggtctgcgacc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3430410..3431699) /gene="murAB" /locus_tag="BSU_37100" /old_locus_tag="BSU37100" /EC_number="2.5.1.7" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:14763982, 19270101" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14763982, 19270101; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylglucosamine 1-carboxyvinyltransferase" /protein_id="NP_391591.2" /db_xref="EnsemblGenomes-Gn:BSU37100" /db_xref="EnsemblGenomes-Tr:CAB15727" /db_xref="GOA:P19670" /db_xref="InterPro:IPR001986" /db_xref="InterPro:IPR005750" /db_xref="InterPro:IPR013792" /db_xref="InterPro:IPR036968" /db_xref="SubtiList:BG10414" /db_xref="UniProtKB/Swiss-Prot:P19670" /translation="MEKLNIAGGDSLNGTVHISGAKNSAVALIPATILANSEVTIEGL PEISDIETLRDLLKEIGGNVHFENGEMVVDPTSMISMPLPNGKVKKLRASYYLMGAML GRFKQAVIGLPGGCHLGPRPIDQHIKGFEALGAEVTNEQGAIYLRAERLRGARIYLDV VSVGATINIMLAAVLAEGKTIIENAAKEPEIIDVATLLTSMGAKIKGAGTNVIRIDGV KELHGCKHTIIPDRIEAGTFMIAGAAMGKEVIIDNVIPTHLESLTAKLREMGYHIETS DDQLLIVGGQKNLKPVDVKTLVYPGFPTDLQQPMTALLTRAKGTSVVTDTIYSARFKH IDELRRMGANMKVEGRSAIITGPVELQGAKVKASDLRAGACLVVAGLMADGVTEITGL EHIDRGYSSLEKKLEGLGATIWRERMTDEEIEQLQNS*" /label="murAB CDS" gene complement(3430410..3431699) /gene="murAB" /locus_tag="BSU_37100" /old_locus_tag="BSU37100" /label="murAB gene" S_feature complement(3431700..3432059) /Source="Nicolas_S_feature" /locus_tag="new_3807376_3807735_c" /HighExp="dia5, Fru, UNK1, Glucon, HiOs, T-5.40H, nit, SMM, MG 120, Mal" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.16076699999999999" /TUshortSig="SigA, SigH" /TUshortPSig="1, 1" /TUlongSig="SigA" /TUlongPSig="0.997" /label="S1437" CDS complement(3432078..3432716) /gene="tal" /locus_tag="BSU_37110" /old_locus_tag="BSU37110" /EC_number="2.2.1.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:4275311, 12469342, 22212631, 23468065" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4275311, 12469342, 22212631, 23468065; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="transaldolase" /protein_id="NP_391592.3" /db_xref="EnsemblGenomes-Gn:BSU37110" /db_xref="EnsemblGenomes-Tr:CAB15728" /db_xref="GOA:P19669" /db_xref="InterPro:IPR001585" /db_xref="InterPro:IPR004731" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR018225" /db_xref="InterPro:IPR022999" /db_xref="InterPro:IPR033919" /db_xref="PDB:3R8R" /db_xref="SubtiList:BG10413" /db_xref="UniProtKB/Swiss-Prot:P19669" /translation="MLFFVDTANIDEIREANELGILAGVTTNPSLVAKEANVSFHDRL REITDVVKGSVSAEVISLKAEEMIEEGKELAKIAPNITVKIPMTSDGLKAVRALTDLG IKTNVTLIFNANQALLAARAGATYVSPFLGRLDDIGHNGLDLISEVKQIFDIHGLDTQ IIAASIRHPQHVTEAALRGAHIGTMPLKVIHALTKHPLTDKGIEQFLADWNK*" /label="tal CDS" gene complement(3432078..3432716) /gene="tal" /locus_tag="BSU_37110" /old_locus_tag="BSU37110" /label="tal gene" downshifts complement(3432104) /Source="Nicolas_upshifts" /id="D1919" /incds=0 /nref=6 /ntot=65 /MaxReadThrough="6.97243" /MaxDrop="4.038" /score="-6.93331064" /energy="-18.4" /TU="U2921,U2922" /idTUdmin="U2926" /TUdmin=1716 /isTUend="FALSE" /label="downshifts" S_feature complement(3432717..3432835) /Source="Nicolas_S_feature" /locus_tag="new_3808393_3808511_c" /HighExp="dia5, LBGtran, M40t45, Lbtran, Mt0, M40t90, M0t45, Lbstat, Lbexp, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH" /TUshortPSig="1, 1" /TUlongSig="SigA" /TUlongPSig="0.997" /label="S1438" CDS complement(3432836..3433693) /gene="fbaA" /locus_tag="BSU_37120" /old_locus_tag="BSU37120" /EC_number="4.1.2.13" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10559165, 10658656, 12682299, 14526031, 17420574, 18310071, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10559165, 10658656, 12682299, 14526031, 17420574, 18310071, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fructose-1,6-bisphosphate aldolase" /protein_id="NP_391593.1" /db_xref="EnsemblGenomes-Gn:BSU37120" /db_xref="EnsemblGenomes-Tr:CAB15729" /db_xref="GOA:P13243" /db_xref="InterPro:IPR000771" /db_xref="InterPro:IPR011289" /db_xref="InterPro:IPR013785" /db_xref="SubtiList:BG10412" /db_xref="UniProtKB/Swiss-Prot:P13243" /translation="MPLVSMTEMLNTAKEKGYAVGQFNLNNLEFTQAILQAAEEEKSP VILGVSEGAGRYMGGFKTVVAMVKALMEEYKVTVPVAIHLDHGSSFESCAKAIHAGFT SVMIDASHHPFEENVATTAKVVELAHFHGVSVEAELGTVGGQEDDVIAEGVIYADPKE CQELVERTGIDCLAPALGSVHGPYKGEPNLGFKEMEEIGKSTGLPLVLHGGTGIPTAD IKKSISLGTAKINVNTENQISSAKAVRETLAAKPDEYDPRKYLGPAREAIKETVIGKM REFGSSNQA*" /label="fbaA CDS" gene complement(3432836..3433693) /gene="fbaA" /locus_tag="BSU_37120" /old_locus_tag="BSU37120" /label="fbaA gene" S_feature complement(3433694..3433820) /Source="Nicolas_S_feature" /locus_tag="new_3809370_3809496_c" /HighExp="C90, Lbtran, LBGtran, dia5, LBGexp, aero, M0t90, Glu, Lbexp, MG 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH" /TUshortPSig="1, 1" /TUlongSig="SigA" /TUlongPSig="0.997" /label="S1439" promotor_-10 complement(3433802..3433821) /Source="Nicolas_upshift_promotors" /id="U2921" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.807192807192807" /psig=1 /xcortree=2356 /SigmaFactorBS="taactgacaaaaagaagaaacaaatgaatcatgtcattATGT TGCCgatttgtcgaaaaGTTGGTATCCTAGTTATGGAgaaaaagcgatctgagtattt a" /listShort="S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI, S1436, rho, S1435, rpmEA" /listLong="tdk" /label="promotor_-10" upshifts complement(3433820) /Source="Nicolas_upshifts" /id="U2921" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.807192807192807" /psig=1 /xcortree=2356 /SigmaFactorBS="taactgacaaaaagaagaaacaaatgaatcatgtcattATGT TGCCgatttgtcgaaaaGTTGGTATCCTAGTTATGGAgaaaaagcgatctgagtattt a" /listShort="S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI, S1436, rho, S1435, rpmEA" /listLong="tdk" /label="upshifts" promotor_-35 complement(3433835..3433842) /Source="Nicolas_upshift_promotors" /id="U2921" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.807192807192807" /psig=1 /xcortree=2356 /SigmaFactorBS="taactgacaaaaagaagaaacaaatgaatcatgtcattATGT TGCCgatttgtcgaaaaGTTGGTATCCTAGTTATGGAgaaaaagcgatctgagtattt a" /listShort="S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI, S1436, rho, S1435, rpmEA" /listLong="tdk" /label="promotor_-35" CDS complement(3433874..3434248) /gene="spo0F" /locus_tag="BSU_37130" /old_locus_tag="BSU37130" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8257105, 11934609, 16788205, 17350627, 19004019, 19040634, 20413551, 22267516, 25256619, 26055117, 27543719" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8257105, 11934609, 16788205, 17350627, 19004019, 19040634, 20413551, 22267516, 25256619, 26055117, 27543719; Product type r : regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator of sporulation initiation" /protein_id="NP_391594.1" /db_xref="EnsemblGenomes-Gn:BSU37130" /db_xref="EnsemblGenomes-Tr:CAB15730" /db_xref="GOA:P06628" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="PDB:1F51" /db_xref="PDB:1FSP" /db_xref="PDB:1NAT" /db_xref="PDB:1PEY" /db_xref="PDB:1PUX" /db_xref="PDB:1SRR" /db_xref="PDB:2FSP" /db_xref="PDB:2FTK" /db_xref="PDB:2JVI" /db_xref="PDB:2JVJ" /db_xref="PDB:2JVK" /db_xref="PDB:3Q15" /db_xref="SubtiList:BG10411" /db_xref="UniProtKB/Swiss-Prot:P06628" /translation="MMNEKILIVDDQYGIRILLNEVFNKEGYQTFQAANGLQALDIVT KERPDLVLLDMKIPGMDGIEILKRMKVIDENIRVIIMTAYGELDMIQESKELGALTHF AKPFDIDEIRDAVKKYLPLKSN*" /label="spo0F CDS" gene complement(3433874..3434248) /gene="spo0F" /locus_tag="BSU_37130" /old_locus_tag="BSU37130" /label="spo0F gene" promotor_-10 complement(3434288..3434306) /Source="Nicolas_upshift_promotors" /id="U2922" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=533 /SigmaFactorBS="atgctcagaaaatgtcgtaaagtagactattataattAAAGG AAATaggaaaatcaAACAGAATACATACAATACtgcttacttttgacgaaaatcataa t" /listShort="spo0F, S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI" /listLong="S1436, rho, S1435, rpmEA, tdk" /label="promotor_-10" upshifts complement(3434302) /Source="Nicolas_upshifts" /id="U2922" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=533 /SigmaFactorBS="atgctcagaaaatgtcgtaaagtagactattataattAAAGG AAATaggaaaatcaAACAGAATACATACAATACtgcttacttttgacgaaaatcataa t" /listShort="spo0F, S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI" /listLong="S1436, rho, S1435, rpmEA, tdk" /label="upshifts" S_feature complement(3434304..3434943) /Source="Nicolas_S_feature" /locus_tag="new_3809980_3810619_c" /HighExp="dia15, Diami, dia5, G135, Etha, G150, G180, Salt, H2O2, Paraq" /AntisenseName="ywjG" /AntisenseCor="0.58536525532649697" /AntisenseRegPval="-25.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1440" promotor_-35 3434305..3434308 /Source="Nicolas_upshift_promotors" /id="U2923" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.456543456543457" /psig=1 /xcortree=2539 /SigmaFactorBS="aaaagtaagcagtattgtatgtattctgTTTGattttcctat ttcctTTAATTATAATAGTCTACTTtacgacattttctgagcattttctcttttgttg t" /listShort="ywjG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(3434317..3434325) /Source="Nicolas_upshift_promotors" /id="U2922" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=533 /SigmaFactorBS="atgctcagaaaatgtcgtaaagtagactattataattAAAGG AAATaggaaaatcaAACAGAATACATACAATACtgcttacttttgacgaaaatcataa t" /listShort="spo0F, S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI" /listLong="S1436, rho, S1435, rpmEA, tdk" /label="promotor_-35" promotor_-10 3434324..3434343 /Source="Nicolas_upshift_promotors" /id="U2923" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.456543456543457" /psig=1 /xcortree=2539 /SigmaFactorBS="aaaagtaagcagtattgtatgtattctgTTTGattttcctat ttcctTTAATTATAATAGTCTACTTtacgacattttctgagcattttctcttttgttg t" /listShort="ywjG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3434337 /Source="Nicolas_upshifts" /id="U2923" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.456543456543457" /psig=1 /xcortree=2539 /SigmaFactorBS="aaaagtaagcagtattgtatgtattctgTTTGattttcctat ttcctTTAATTATAATAGTCTACTTtacgacattttctgagcattttctcttttgttg t" /listShort="ywjG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3434351..3434356 /Source="Nicolas_upshift_promotors" /id="U2924" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.626373626373626" /psig="0.977022977022977" /xcortree=1775 /SigmaFactorBS="ctttaattataatagtctactttacgacaTTTTCTgagcatt ttctctttTGTTGTATACTGATATTGTAcgttataaaggaggattcacttatgttgaa a" /listShort="ywjG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3434372..3434391 /Source="Nicolas_upshift_promotors" /id="U2924" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.626373626373626" /psig="0.977022977022977" /xcortree=1775 /SigmaFactorBS="ctttaattataatagtctactttacgacaTTTTCTgagcatt ttctctttTGTTGTATACTGATATTGTAcgttataaaggaggattcacttatgttgaa a" /listShort="ywjG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3434382 /Source="Nicolas_upshifts" /id="U2924" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.626373626373626" /psig="0.977022977022977" /xcortree=1775 /SigmaFactorBS="ctttaattataatagtctactttacgacaTTTTCTgagcatt ttctctttTGTTGTATACTGATATTGTAcgttataaaggaggattcacttatgttgaa a" /listShort="ywjG" /GFF_Attribute="listLong" /label="upshifts" CDS 3434414..3434935 /gene="ywjG" /locus_tag="BSU_37140" /old_locus_tag="BSU37140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391595.1" /db_xref="EnsemblGenomes-Gn:BSU37140" /db_xref="EnsemblGenomes-Tr:CAB15731" /db_xref="InterPro:IPR019676" /db_xref="SubtiList:BG11053" /db_xref="UniProtKB/Swiss-Prot:P06629" /translation="MLKIFTTQLTGIFSRIQDKESDAIEDGARLLAQAVISGHSIYLY GANELQGVFYEATESKEPFPSVKAFPENAEEVTESDRVLMFCSGTGTAEEQELAKELY EKGAGVVCVSPAAKDSAGIEQYCDVHIDSKLKMPLVPDEDGTRYGFPSLMTALYVYHA LSFTLKEILQEYA*" /label="ywjG CDS" gene 3434414..3434935 /gene="ywjG" /locus_tag="BSU_37140" /old_locus_tag="BSU37140" /label="ywjG gene" promotor_-35 3434878..3434881 /Source="Nicolas_upshift_promotors" /id="U2925" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.936063936063936" /psig="0.99000999000999" /xcortree=1781 /SigmaFactorBS="acgggtttccctctttaatgacagcactGTATgtctatcacg ctttATCGTTTACACTAAAAGAAAttctgcaagagtatgcataatatcttattgtaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3434896..3434915 /Source="Nicolas_upshift_promotors" /id="U2925" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.936063936063936" /psig="0.99000999000999" /xcortree=1781 /SigmaFactorBS="acgggtttccctctttaatgacagcactGTATgtctatcacg ctttATCGTTTACACTAAAAGAAAttctgcaagagtatgcataatatcttattgtaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3434910 /Source="Nicolas_upshifts" /id="U2925" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.936063936063936" /psig="0.99000999000999" /xcortree=1781 /SigmaFactorBS="acgggtttccctctttaatgacagcactGTATgtctatcacg ctttATCGTTTACACTAAAAGAAAttctgcaagagtatgcataatatcttattgtaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3434933..3434952) /Source="Nicolas_upshift_promotors" /id="U2926" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.705294705294705" /psig="0.997002997002997" /xcortree=1956 /SigmaFactorBS="ccgtttgtcaaaagcgggcaagtctttttTATTTGTTtccgg caagttccaGCATGTACAATAAGATATTAtgcatactcttgcagaatttcttttagtg t" /listShort="S1440, spo0F" /listLong="S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI, S1436, rho, S1435, rpmEA, tdk" /label="promotor_-10" upshifts complement(3434943) /Source="Nicolas_upshifts" /id="U2926" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.705294705294705" /psig="0.997002997002997" /xcortree=1956 /SigmaFactorBS="ccgtttgtcaaaagcgggcaagtctttttTATTTGTTtccgg caagttccaGCATGTACAATAAGATATTAtgcatactcttgcagaatttcttttagtg t" /listShort="S1440, spo0F" /listLong="S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI, S1436, rho, S1435, rpmEA, tdk" /label="upshifts" downshifts 3434954 /Source="Nicolas_upshifts" /id="D1920" /incds=0 /nref=191 /ntot=242 /MaxReadThrough="1.98527" /MaxDrop="5.8354" /score="11.5531593" /energy="-11.9" /TU="NA" /idTUdmin="U2923" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 complement(3434967..3434974) /Source="Nicolas_upshift_promotors" /id="U2926" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.705294705294705" /psig="0.997002997002997" /xcortree=1956 /SigmaFactorBS="ccgtttgtcaaaagcgggcaagtctttttTATTTGTTtccgg caagttccaGCATGTACAATAAGATATTAtgcatactcttgcagaatttcttttagtg t" /listShort="S1440, spo0F" /listLong="S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI, S1436, rho, S1435, rpmEA, tdk" /label="promotor_-35" CDS complement(3435017..3436624) /gene="pyrG" /locus_tag="BSU_37150" /old_locus_tag="BSU37150" /EC_number="6.3.4.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11544212, 15252202, 17158658, 17302819" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11544212, 15252202, 17158658, 17302819; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="CTP synthetase" /protein_id="NP_391596.1" /db_xref="EnsemblGenomes-Gn:BSU37150" /db_xref="EnsemblGenomes-Tr:CAB15743" /db_xref="GOA:P13242" /db_xref="InterPro:IPR004468" /db_xref="InterPro:IPR017456" /db_xref="InterPro:IPR017926" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR029062" /db_xref="InterPro:IPR033828" /db_xref="SubtiList:BG10410" /db_xref="UniProtKB/Swiss-Prot:P13242" /translation="MTKYIFVTGGVVSSLGKGIVAASLGRLLKNRGLNVTIQKFDPYI NVDPGTMSPYQHGEVFVTDDGAETDLDLGHYERFIDINLNKFSNVTTGKIYSTVLKKE RRGDYLGGTVQVIPHITNELKDRVYRAGKETNADVVITEIGGTVGDIESLPFLEAIRQ MKSDIGRENVMYIHCTLVPYIKAAGELKTKPTQHSVKELRSLGIQPNIIVVRTEMPIS QDMKDKIALFCDIDTKAVIECEDADNLYSIPLELQKQGLDKLVCEHMKLACKEAEMSE WKELVNKVSNLSQTITIGLVGKYVELPDAYISVVESLRHAGYAFDTDVKVKWINAEEV TENNIAELTSGTDGIIVPGGFGDRGVEGKIVATKYARENNIPFLGICLGMQVASIEYA RNVLGLKGAHSAEIDPSTQYPIIDLLPEQKDVEDLGGTLRLGLYPCKLEEGTKAFEVY QDEVVYERHRHRYEFNNEFRQQMEEQGFVFSGTSPDGRLVEIIELKDHPWFVASQFHP EFKSRPTRPQPLFKGFIGASVEAANQK*" /label="pyrG CDS" gene complement(3435017..3436624) /gene="pyrG" /locus_tag="BSU_37150" /old_locus_tag="BSU37150" /label="pyrG gene" downshifts complement(3435030) /Source="Nicolas_upshifts" /id="D1921" /incds=0 /nref=222 /ntot=259 /MaxReadThrough="2.2929" /MaxDrop="8.17874" /score="18.9699606" /energy="-12.1" /TU="NA" /idTUdmin="U2927" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3436625..3436812) /Source="Nicolas_S_feature" /locus_tag="new_3812301_3812488_c" /HighExp="LBGexp, Lbexp, dia0, G150, G135, G180, Paraq, Oxctl, dia15, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.999, 0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1441" promotor_-10 complement(3436800..3436819) /Source="Nicolas_upshift_promotors" /id="U2927" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig="0.999000999001" /xcortree=2660 /SigmaFactorBS="taaatagtatcagatttcatcttcaaaacgaTCTTGACTttc atagtcgaactATGTAGTATGTATTTTGGGCtcttcaaaaacgaagagagaacatagt a" /listShort="S1441, pyrG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3436812) /Source="Nicolas_upshifts" /id="U2927" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig="0.999000999001" /xcortree=2660 /SigmaFactorBS="taaatagtatcagatttcatcttcaaaacgaTCTTGACTttc atagtcgaactATGTAGTATGTATTTTGGGCtcttcaaaaacgaagagagaacatagt a" /listShort="S1441, pyrG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3436834..3436841) /Source="Nicolas_upshift_promotors" /id="U2927" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig="0.999000999001" /xcortree=2660 /SigmaFactorBS="taaatagtatcagatttcatcttcaaaacgaTCTTGACTttc atagtcgaactATGTAGTATGTATTTTGGGCtcttcaaaaacgaagagagaacatagt a" /listShort="S1441, pyrG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3436866..3437387) /gene="rpoE" /locus_tag="BSU_37160" /old_locus_tag="BSU37160" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:189250, 9795209, 10336502, 10438769, 10672039, 10910724, 11029421, 23543716, 26546673, 27679485" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 189250, 9795209, 10336502, 10438769, 10672039, 10910724, 11029421, 23543716, 26546673, 27679485; Product type f: factor" /codon_start=1 /transl_table=11 /product="RNA polymerase (delta subunit) and transcriptional repressor" /protein_id="NP_391597.1" /db_xref="EnsemblGenomes-Gn:BSU37160" /db_xref="EnsemblGenomes-Tr:CAB15744" /db_xref="GOA:P12464" /db_xref="InterPro:IPR007759" /db_xref="InterPro:IPR029757" /db_xref="PDB:2KRC" /db_xref="PDB:2M4K" /db_xref="PDB:4NC7" /db_xref="PDB:4NC8" /db_xref="SubtiList:BG10409" /db_xref="UniProtKB/Swiss-Prot:P12464" /translation="MGIKQYSQEELKEMALVEIAHELFEEHKKPVPFQELLNEIASLL GVKKEELGDRIAQFYTDLNIDGRFLALSDQTWGLRSWYPYDQLDEETQPTVKAKKKKA KKAVEEDLDLDEFEEIDEDDLDLDEVEEELDLEADDFDEEDLDEDDDDLEIEEDIIDE DDEDYDDEEEEIK*" /label="rpoE CDS" gene complement(3436866..3437387) /gene="rpoE" /locus_tag="BSU_37160" /old_locus_tag="BSU37160" /label="rpoE gene" downshifts complement(3436922) /Source="Nicolas_upshifts" /id="D1922" /incds=0 /nref=7 /ntot=182 /MaxReadThrough="6.49215" /MaxDrop="3.2129" /score="19.8764263" /energy="-19.4" /TU="U2928,U2929" /idTUdmin="U2927" /TUdmin="-1892" /isTUend="FALSE" /label="downshifts" S_feature complement(3437388..3437490) /Source="Nicolas_S_feature" /locus_tag="new_3813064_3813166_c" /HighExp="H2O2, Paraq, Oxctl, LBGexp, G180, dia15, dia0, Lbexp, BMM, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1442" promotor_-10 complement(3437471..3437490) /Source="Nicolas_upshift_promotors" /id="U2928" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=2550 /SigmaFactorBS="ggatcactcttgtaaaattatttaaattaacgctgttaaggG TAGcatattctgttttatTTTGTTTATAATGAGAGGTAtggtttgtataagaacgata c" /listShort="S1442, rpoE, S1441, pyrG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3437490) /Source="Nicolas_upshifts" /id="U2928" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=2550 /SigmaFactorBS="ggatcactcttgtaaaattatttaaattaacgctgttaaggG TAGcatattctgttttatTTTGTTTATAATGAGAGGTAtggtttgtataagaacgata c" /listShort="S1442, rpoE, S1441, pyrG" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3437492..3437569) /Source="Nicolas_S_feature" /locus_tag="new_3813168_3813245_c" /HighExp="T0.30H, S8, S7, S6, S4, S3, S5, Sw, BC, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1443" promotor_-35 complement(3437506..3437509) /Source="Nicolas_upshift_promotors" /id="U2928" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=2550 /SigmaFactorBS="ggatcactcttgtaaaattatttaaattaacgctgttaaggG TAGcatattctgttttatTTTGTTTATAATGAGAGGTAtggtttgtataagaacgata c" /listShort="S1442, rpoE, S1441, pyrG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3437570..3438709) /gene="acdA" /locus_tag="BSU_37170" /old_locus_tag="BSU37170" /EC_number="1.3.99.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17189250, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acyl-CoA dehydrogenase" /protein_id="NP_391598.1" /db_xref="EnsemblGenomes-Gn:BSU37170" /db_xref="EnsemblGenomes-Tr:CAB15745" /db_xref="GOA:P45867" /db_xref="InterPro:IPR006089" /db_xref="InterPro:IPR006091" /db_xref="InterPro:IPR009075" /db_xref="InterPro:IPR009100" /db_xref="InterPro:IPR013786" /db_xref="InterPro:IPR036250" /db_xref="InterPro:IPR037069" /db_xref="SubtiList:BG11239" /db_xref="UniProtKB/Swiss-Prot:P45867" /translation="MNFSLSEEHEMIRKLVRDFAKHEVAPTAAERDEQERFDRELFRE MANLGLTGIPWPEDYGGIGSDYLAYVIAVEELSKVCASTGVTLSAHISLCSWPLFAFG TEEQKTEYLTQLALGEKIGAFALTEAGSGSDAGSMKTTAERIGDDYVLNGSKVFITNG GVADIYIVFAVTDPEKKKKGVTAFIVEKDFEGFFTGKKEKKLGIRSSPTTEIMFEDCV VPASKRLGEEGEGFKIAMKTLDGGRNGIAAQAVGIAQGALDAALQYAKERKQFGKSIA EQQGIAFKLADMATMIEASRLLTYQAAWLESSGLPYGKASAMSKLMAGDTAMKVTTEA VQIFGGYGYTKDYPVERYMRDAKITQIYEGTQEIQRLVISRMLAD*" /label="acdA CDS" gene complement(3437570..3438709) /gene="acdA" /locus_tag="BSU_37170" /old_locus_tag="BSU37170" /label="acdA gene" CDS complement(3438706..3440823) /gene="fadF" /locus_tag="BSU_37180" /old_locus_tag="BSU37180" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative iron-sulphur-binding reductase" /protein_id="NP_391599.1" /db_xref="EnsemblGenomes-Gn:BSU37180" /db_xref="EnsemblGenomes-Tr:CAB15746" /db_xref="GOA:P45866" /db_xref="InterPro:IPR004017" /db_xref="InterPro:IPR009051" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR017900" /db_xref="InterPro:IPR036197" /db_xref="SubtiList:BG11311" /db_xref="UniProtKB/Swiss-Prot:P45866" /translation="MSGFLIANALLFLIVTAYAVYLFVYLVKTRLAYIKLGQKEQFDQ RFKERLHAIWVNVFGQKKLLKDKKSGIIHVMFFYGFILVQFGAIDFIIKGLAPGRNLS LGPVYPAFTFFQEIVTFLILIAVGWAFYRRYIEKLVRLKRGFKAGLVLIFIGGLMLTV LLGNGMNLIWHEHGLSWSEPIASGIAFMLSGVGKTGAAVIFYIAWWIHLLFLLSFLVY VPQSKHAHLIAGPANVFFNRMESAGKLEKIDFTDETKESYGAGKIEDFRQSQLLDLYA CVECGRCTNMCPATGTGKMLSPMDLILRLRDHLTEKGAAVTSRSPWVPAAAFRHTRGN QLAAASAGSGSQEAAAALDYNPSLIGDVITEEEIWACTTCRNCEDQCPVMNEHVDKII DLRRYLVLTEGKMDSDAQRAMTSIERQGNPWGLNRKERENWRDEAPDAEIPTVKEMKK EGKEFEYLFWVGSMGSYDNRSQKIAISFAKLLNHAGVSFAILGNKEKNSGDTPRRLGN EFLFQELAEKNISEFEKNDVKKIVTIDPHAYNLFKNEYPDFGFEGEVYHHTEVLAELV KNGKLRPQHPLHETITFHDSCYLGRYNEVYDPPREILKAIPGVQLVEMERSRETGMCC GAGGGLMWMEEETGNRINVARTEQALAVNPSVISSGCPYCLTMLGDGTKAKEAEDQVK TYDVVELLAQSVLGADLKMGEKQ*" /label="fadF CDS" gene complement(3438706..3440823) /gene="fadF" /locus_tag="BSU_37180" /old_locus_tag="BSU37180" /label="fadF gene" S_feature complement(3440824..3440882) /Source="Nicolas_S_feature" /locus_tag="new_3816500_3816558_c" /HighExp="T0.30H, S6, BC, S8, S7, Sw, S5, S4, Lbstat, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1444" promotor_-10 complement(3440883..3440902) /Source="Nicolas_upshift_promotors" /id="U2929" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.526473526473527" /psig=1 /xcortree=373 /SigmaFactorBS="aaaggtagtgtgcccgaacagcaggaatttaatTATTGACTg aacactcattcaTTATTTATCATAAAGATAATcttatacagattcgggggtaggggat c" /listShort="S1444, fadF, acdA, S1443, S1442, rpoE, S1441, pyrG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3440896) /Source="Nicolas_upshifts" /id="U2929" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.526473526473527" /psig=1 /xcortree=373 /SigmaFactorBS="aaaggtagtgtgcccgaacagcaggaatttaatTATTGACTg aacactcattcaTTATTTATCATAAAGATAATcttatacagattcgggggtaggggat c" /listShort="S1444, fadF, acdA, S1443, S1442, rpoE, S1441, pyrG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3440916..3440923) /Source="Nicolas_upshift_promotors" /id="U2929" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.526473526473527" /psig=1 /xcortree=373 /SigmaFactorBS="aaaggtagtgtgcccgaacagcaggaatttaatTATTGACTg aacactcattcaTTATTTATCATAAAGATAATcttatacagattcgggggtaggggat c" /listShort="S1444, fadF, acdA, S1443, S1442, rpoE, S1441, pyrG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3440922..3440928 /Source="Nicolas_upshift_promotors" /id="U2930" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=886 /SigmaFactorBS="tctttatgataaataatgaatgagtgttcagtcaaTAATTAA attcctgctgttcGGGCACACTACCtttactacggaaaggagtgccggtatgaaggta t" /listShort="clsB, ywjD, ywjC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3440942..3440953 /Source="Nicolas_upshift_promotors" /id="U2930" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=886 /SigmaFactorBS="tctttatgataaataatgaatgagtgttcagtcaaTAATTAA attcctgctgttcGGGCACACTACCtttactacggaaaggagtgccggtatgaaggta t" /listShort="clsB, ywjD, ywjC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3440947 /Source="Nicolas_upshifts" /id="U2930" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=886 /SigmaFactorBS="tctttatgataaataatgaatgagtgttcagtcaaTAATTAA attcctgctgttcGGGCACACTACCtttactacggaaaggagtgccggtatgaaggta t" /listShort="clsB, ywjD, ywjC" /GFF_Attribute="listLong" /label="upshifts" CDS 3440978..3442174 /gene="clsB" /locus_tag="BSU_37190" /old_locus_tag="BSU37190" /EC_number="2.7.8.-" /function="16.8: Protect" /function="16.13: Shape" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:14973018, 16514141, 18820022" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14973018, 16514141, 18820022; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="minor cardiolipin synthetase (phospholipase D family)" /protein_id="NP_391600.1" /db_xref="EnsemblGenomes-Gn:BSU37190" /db_xref="EnsemblGenomes-Tr:CAB15747" /db_xref="GOA:P45865" /db_xref="InterPro:IPR001736" /db_xref="InterPro:IPR022924" /db_xref="InterPro:IPR025202" /db_xref="SubtiList:BG11310" /db_xref="UniProtKB/Swiss-Prot:P45865" /translation="MKVFIVIMIIVVIFFALILLDIFMGRAGYRKKAYEPVFSKKKSD IELIHCGADLVERMMNDIRQAASSVHMMFFIMKNDEVSHNMYTLLKTKAQAGVSVYLL LDWAGCRAIKKTALQTMKNAGVHVHVMNRPRFPFFFFHMQKRNHRKITVIDGKIGYIG GFNIAEEYLGKKAKFGNWEDYHLRMIGEGVHDLQTLFASDLKRNTGIELGSDVWPKLQ QGTISHKIYATDGYSLENIYLANIAQAKNRLTVCTPYYIPSKPLQEALINARKNGVSV RIIVPMKSDHPLVREAAFTYYSELLDAGCLIYRYYQGFYHVKALIIDDHLSIIGTANF DKRSLFLNEEVNVEIDDEAFTSEVYATIEEDMKKSELLTMEDFSKRTFRQRPAEWLGR ALSYFL*" /label="clsB CDS" gene 3440978..3442174 /gene="clsB" /locus_tag="BSU_37190" /old_locus_tag="BSU37190" /label="clsB gene" S_feature complement(3441170..3442048) /Source="Nicolas_S_feature" /locus_tag="new_3816846_3817724_c" /HighExp="S4, S5, S3, S6, S7, S8, BT, B36, LoTm, B60" /AntisenseName="clsB" /AntisenseCor="0.84883232203587" /AntisenseRegPval="-75.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1445" promotor_-10 complement(3442038..3442056) /Source="Nicolas_upshift_promotors" /id="U2931" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1122 /SigmaFactorBS="tgaaatcctccatcgtcagcagctccgactttTTCATAtcct cctcaattgtgGCATAGACTTCACTTGTAAacgcttcgtcatcaatttcaacattcac c" /listShort="S1445" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3442049) /Source="Nicolas_upshifts" /id="U2931" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1122 /SigmaFactorBS="tgaaatcctccatcgtcagcagctccgactttTTCATAtcct cctcaattgtgGCATAGACTTCACTTGTAAacgcttcgtcatcaatttcaacattcac c" /listShort="S1445" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3442072..3442077) /Source="Nicolas_upshift_promotors" /id="U2931" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1122 /SigmaFactorBS="tgaaatcctccatcgtcagcagctccgactttTTCATAtcct cctcaattgtgGCATAGACTTCACTTGTAAacgcttcgtcatcaatttcaacattcac c" /listShort="S1445" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3442187..3443149 /gene="uvsE" /locus_tag="BSU_37200" /old_locus_tag="BSU37200" /EC_number="3.-.-.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:8614629, 22961846" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8614629, 22961846; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UV DNA damage repair endonuclease" /protein_id="NP_391601.1" /db_xref="EnsemblGenomes-Gn:BSU37200" /db_xref="EnsemblGenomes-Tr:CAB15748" /db_xref="GOA:P45864" /db_xref="InterPro:IPR004601" /db_xref="InterPro:IPR023520" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG11309" /db_xref="UniProtKB/Swiss-Prot:P45864" /translation="MIFRFGFVSNAMSLWDASPAKTLTFARYSKLSKTERKEALLTVT KANLRNTMRTLHYIIGHGIPLYRFSSSIVPLATHPDVMWDFVTPFQKEFREIGELVKT HQLRTSFHPNQFTLFTSPKESVTKNAVTDMAYHYRMLEAMGIADRSVINIHIGGAYGN KDTATAQFHQNIKQLPQEIKERMTLENDDKTYTTEETLQVCEQEDVPFVFDFHHFYAN PDDHADLNVALPRMIKTWERIGLQPKVHLSSPKSEQAIRSHADYVDANFLLPLLERFR QWGTNIDFMIEAKQKDKALLRLMDELSSIRGVKRIGGGALQWKS*" /label="uvsE CDS" gene 3442187..3443149 /gene="uvsE" /locus_tag="BSU_37200" /old_locus_tag="BSU37200" /label="uvsE gene" promotor_-35 3443163..3443169 /Source="Nicolas_upshift_promotors" /id="U2932" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=217 /SigmaFactorBS="gcggtgcgctgcaatggaagtcataaatgtgcaaaaataGGT TTACgacttgtcagctttGGGAACTTAGGCTATATAAgacaacaatcgatggaggaga a" /listShort="ywjC, S1446" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3443184..3443202 /Source="Nicolas_upshift_promotors" /id="U2932" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=217 /SigmaFactorBS="gcggtgcgctgcaatggaagtcataaatgtgcaaaaataGGT TTACgacttgtcagctttGGGAACTTAGGCTATATAAgacaacaatcgatggaggaga a" /listShort="ywjC, S1446" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3443184 /Source="Nicolas_upshifts" /id="U2932" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=217 /SigmaFactorBS="gcggtgcgctgcaatggaagtcataaatgtgcaaaaataGGT TTACgacttgtcagctttGGGAACTTAGGCTATATAAgacaacaatcgatggaggaga a" /listShort="ywjC, S1446" /GFF_Attribute="listLong" /label="upshifts" CDS 3443230..3443502 /gene="ywjC" /locus_tag="BSU_37210" /old_locus_tag="BSU37210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391602.1" /db_xref="EnsemblGenomes-Gn:BSU37210" /db_xref="EnsemblGenomes-Tr:CAB15749" /db_xref="InterPro:IPR035895" /db_xref="SubtiList:BG11308" /db_xref="UniProtKB/Swiss-Prot:P45863" /translation="MKNIKSLKVAAQAFTLRNLIHLYKMCHSGSHEVYIYSKKTMCKI KSLIELETFRMAHNEKEYLIVVEGTKASQLIEKFQNLIEPAEREAL*" /label="ywjC CDS" gene 3443230..3443502 /gene="ywjC" /locus_tag="BSU_37210" /old_locus_tag="BSU37210" /label="ywjC gene" downshifts complement(3443236) /Source="Nicolas_upshifts" /id="D1923" /incds=0 /nref=4 /ntot=17 /MaxReadThrough="1.03516" /MaxDrop="5.08765" /score="17.8471239" /energy="-10" /TU="NA" /idTUdmin="U2933" /TUdmin=330 /isTUend="FALSE" /label="downshifts" downshifts 3443492 /Source="Nicolas_upshifts" /id="D1924" /incds=0 /nref=54 /ntot=128 /MaxReadThrough="4.49396" /MaxDrop="7.49636" /score="14.0189582" /energy="-10" /TU="U2932" /idTUdmin="U2930" /TUdmin=178 /isTUend="FALSE" /label="downshifts" S_feature 3443537..3443943 /Source="Nicolas_S_feature" /locus_tag="new_3819213_3819619" /HighExp="Etha, C30, Sw, Gly, C90, M/G, BC, Salt, Fru, G135" /AntisenseName="ywjB" /AntisenseCor="0.2646821361217" /AntisenseRegPval="-5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1446" CDS complement(3443544..3444068) /gene="ywjB" /locus_tag="BSU_37220" /old_locus_tag="BSU37220" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12354229, 27795321; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391603.1" /db_xref="EnsemblGenomes-Gn:BSU37220" /db_xref="EnsemblGenomes-Tr:CAB15750" /db_xref="GOA:P45862" /db_xref="InterPro:IPR002734" /db_xref="InterPro:IPR024072" /db_xref="SubtiList:BG11307" /db_xref="UniProtKB/Swiss-Prot:P45862" /translation="MERKTVLYIAVSLDGMIAKEDGSIDWLDEFEGEGDNGYSDFYQT VDTVILGRSTYEHVKVLTPVFPYQDKTCYVFTGSPDSYQDEHVTFINEGARAFTARLK QEKGSNIWIAGGAELVNDFMKEDAIDEFIITVIPVVLGSGIPLFHELTNETKLRLKGT KQFGQAVQLHYVRA*" /label="ywjB CDS" gene complement(3443544..3444068) /gene="ywjB" /locus_tag="BSU_37220" /old_locus_tag="BSU37220" /label="ywjB gene" downshifts complement(3443566) /Source="Nicolas_upshifts" /id="D1925" /incds=0 /nref=194 /ntot=239 /MaxReadThrough="1.38978" /MaxDrop="6.19859" /score="17.8471239" /energy="-10" /TU="NA" /idTUdmin="U2933" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3444078..3445805) /gene="ywjA" /locus_tag="BSU_37230" /old_locus_tag="BSU37230" /EC_number="3.6.3.-" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12119303, 12354229, 25652542; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC lipid transporter (ATP-binding protein)" /protein_id="NP_391604.1" /db_xref="EnsemblGenomes-Gn:BSU37230" /db_xref="EnsemblGenomes-Tr:CAB15751" /db_xref="GOA:P45861" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG11306" /db_xref="UniProtKB/Swiss-Prot:P45861" /translation="MLRQFFSYYKPYKTLFFLDFFSAIAGGLMELSFPLIVNYFIDTL LPGRDWGLIIATSIGLFAVYALSSALQYIVTYWGHMLGINIETDMRKSLFDHLQKLSF KFYDNNKTGTLMSKLTNDLMYIGEVAHHGPEDLFIAVMTILGAFGVMLFINWQLALLT FIIMPIVIWLALYFNKKMTKAFTTLNKDIGDFSARVENNIGGIRLVQAFGNEAFEKER FAVNNQRFRVTKLSSYKIMAKNGSISYMLTRFVTLFVLLCGTWFVIRGSLSYGEFVAF VLLTNVLFRPIDKINAIIEMYPRGIAGFKSYMELMETEPDIQDSPDSKDVSGLKGNIR YKHVSFGYDDHHNVLNDINLSIQAGETVAFVGPSGAGKSTLCSLLPRFYEASEGDITI DGISIKDMTLSSLRGQIGVVQQDVFLFSGTLRENIAYGRLGASEEDIWQAVKQAHLEE LVHNMPDGLDTMIGERGVKLSGGQKQRLSIARMFLKNPSILILDEATSALDTETEAAI QKALQELSEGRTTLVIAHRLATIKDADRIVVVTNNGIEEQGRHQDLIEAGGLYSRLHQ AQFGQMVHR*" /label="ywjA CDS" gene complement(3444078..3445805) /gene="ywjA" /locus_tag="BSU_37230" /old_locus_tag="BSU37230" /label="ywjA gene" promotor_-10 complement(3445839..3445858) /Source="Nicolas_upshift_promotors" /id="U2933" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.397602397602398" /psig="0.999000999001" /xcortree=2106 /SigmaFactorBS="tgttttcaggtgttctgtaagaaaaaagaaatctgATCTTAC aaaacagcccgtgTATAGTATAATTGAGAAATAttatcagttatttatacattggggg a" /listShort="ywjA, ywjB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3445853) /Source="Nicolas_upshifts" /id="U2933" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.397602397602398" /psig="0.999000999001" /xcortree=2106 /SigmaFactorBS="tgttttcaggtgttctgtaagaaaaaagaaatctgATCTTAC aaaacagcccgtgTATAGTATAATTGAGAAATAttatcagttatttatacattggggg a" /listShort="ywjA, ywjB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3445872..3445878) /Source="Nicolas_upshift_promotors" /id="U2933" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.397602397602398" /psig="0.999000999001" /xcortree=2106 /SigmaFactorBS="tgttttcaggtgttctgtaagaaaaaagaaatctgATCTTAC aaaacagcccgtgTATAGTATAATTGAGAAATAttatcagttatttatacattggggg a" /listShort="ywjA, ywjB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3445894..3447396) /gene="clsC" /locus_tag="BSU_37240" /old_locus_tag="BSU37240" /EC_number="2.7.8.-" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 14973018, 15743965, 16514141, 26025016; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="minor cardiolipin synthetase" /protein_id="NP_391605.1" /db_xref="EnsemblGenomes-Gn:BSU37240" /db_xref="EnsemblGenomes-Tr:CAB15752" /db_xref="GOA:P45860" /db_xref="InterPro:IPR001736" /db_xref="InterPro:IPR022924" /db_xref="InterPro:IPR025202" /db_xref="InterPro:IPR027379" /db_xref="InterPro:IPR030874" /db_xref="SubtiList:BG11305" /db_xref="UniProtKB/Swiss-Prot:P45860" /translation="MLKRRLEFFFLYMMLIGAYVIWFFPVSRLEFYGGLLCYISIILF SIYSLILENRTSQHTLLWIHILVFFPIVGYVFYLFSGQLYVKGKLFKTKRMYNREKLR KLFDKEETPEVTGLKDNQERFFTYSIRAAHMNINTKSNIKVLKNGEETFPDIFKAMRK AESYIHIEYYMFKSDMLGRGMMDIMMEKARQGVEVRFLYDAAGSMKLARRDIMRMKQA GVDIVPFSPLKYGFFNQKLNFRNHRKIVIIDGKTGFVGGLNVGKEYISRDPYIGFWRD THLRLEGEIVQTLHAIFMLDWEYVSNEVLIDQEEYNTPVPVEGGGIYQIVATGPDMKE SMSDLYYEMISSAQKSIWIATPYFVPNESIRTALKAAATKGVEVRVMVPEKNDSFLTQ YASRSYFPELLLEGIEVYSYQKGFMHQKVMIIDGDLASVGTANMDMRSFQLNFEVNVF FTDAEAIRTLEAHFEEDMQESEKLSPVGFYKRGVADRTKESFARLFSGVL*" /label="clsC CDS" gene complement(3445894..3447396) /gene="clsC" /locus_tag="BSU_37240" /old_locus_tag="BSU37240" /label="clsC gene" promotor_-10 complement(3447420..3447438) /Source="Nicolas_upshift_promotors" /id="U2934" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=216 /SigmaFactorBS="aacctctcctcctttggcggagaggttttttacttacaaGGT TTATcgattagaaaaaagAGGTAATACAGAGGTAATTgaatcagattggagagaatca g" /listShort="ywiE, ywjA, ywjB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3447438) /Source="Nicolas_upshifts" /id="U2934" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=216 /SigmaFactorBS="aacctctcctcctttggcggagaggttttttacttacaaGGT TTATcgattagaaaaaagAGGTAATACAGAGGTAATTgaatcagattggagagaatca g" /listShort="ywiE, ywjA, ywjB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3447453..3447459) /Source="Nicolas_upshift_promotors" /id="U2934" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=216 /SigmaFactorBS="aacctctcctcctttggcggagaggttttttacttacaaGGT TTATcgattagaaaaaagAGGTAATACAGAGGTAATTgaatcagattggagagaatca g" /listShort="ywiE, ywjA, ywjB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3447483..3447855) /Source="Nicolas_S_feature" /locus_tag="new_3823159_3823531_c" /HighExp="Lbtran, M40t45, nit, LBGtran, LBGstat, S0, ferm, M0t45, Lbstat, BI" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.30294500000000002" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="SigA" /TUlongPSig="0.996" /label="S1447" downshifts complement(3447526) /Source="Nicolas_upshifts" /id="D1926" /incds=0 /nref=4 /ntot=19 /MaxReadThrough="2.94229" /MaxDrop="4.09744" /score="13.5274489" /energy="-11.4" /TU="NA" /idTUdmin="U2935" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3447882..3448553) /gene="narI" /locus_tag="BSU_37250" /old_locus_tag="BSU37250" /EC_number="1.7.99.4" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:7557333, 7860592, 8846791, 11289299, 15849754, 16850406, 22103536" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7557333, 7860592, 8846791, 11289299, 15849754, 16850406, 22103536; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nitrate reductase (gamma subunit)" /protein_id="NP_391606.1" /db_xref="EnsemblGenomes-Gn:BSU37250" /db_xref="EnsemblGenomes-Tr:CAB15753" /db_xref="GOA:P42177" /db_xref="InterPro:IPR003816" /db_xref="InterPro:IPR023234" /db_xref="InterPro:IPR036197" /db_xref="SubtiList:BG11084" /db_xref="UniProtKB/Swiss-Prot:P42177" /translation="MSGQILWGIMPYIVLTIFIGGHIYRYQHDQFGWTAKSSELLEKK KLAAGSTLFHWGLLCVVGGHVMGILIPEGVYASLGISEHMYHKMAIGAGLPAGIAACT GLVILTYRRLFDKRIRKTSSPSDILTLLLLLFMMLSGVAATFLNIDSKGFDYRTTVGP WFREIVLFRPDASLMESVPLWFKFHIVIGYVVFILWPFTRLVHVFSLPLKYLTRSYVV YRKRS*" /label="narI CDS" gene complement(3447882..3448553) /gene="narI" /locus_tag="BSU_37250" /old_locus_tag="BSU37250" /label="narI gene" downshifts complement(3447900) /Source="Nicolas_upshifts" /id="D1927" /incds=0 /nref=4 /ntot=13 /MaxReadThrough="6.70789" /MaxDrop="4.50566" /score="27.8375931" /energy="-11.7" /TU="U2935" /idTUdmin="U2935" /TUdmin="-374" /isTUend="FALSE" /label="downshifts" CDS complement(3448550..3449104) /gene="narJ" /locus_tag="BSU_37260" /old_locus_tag="BSU37260" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:7557333, 7860592, 8846791, 11289299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7557333, 7860592, 8846791, 11289299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nitrate reductase molybdenum cofactor assembly chaperone NarJ" /protein_id="NP_391607.1" /db_xref="EnsemblGenomes-Gn:BSU37260" /db_xref="EnsemblGenomes-Tr:CAB15754" /db_xref="GOA:P42178" /db_xref="InterPro:IPR003765" /db_xref="InterPro:IPR020945" /db_xref="InterPro:IPR036411" /db_xref="SubtiList:BG11083" /db_xref="UniProtKB/Swiss-Prot:P42178" /translation="MNTTDRQITFSALSCLLSYPDEEWRAELPDWKALIQEIGNRQIR EKLLHFFETSASYSPEALIEHYVYTFDFGKKTNMYVTYFNSGEQRERGIELLHLKNTY EQSGFLPTEKELPDYLPLMLEFAAAAEIEAARSVFEKYLSNVRELASRLEKNDSIYAE LLHVLLAALENIGVRESVEGAVQA*" /label="narJ CDS" gene complement(3448550..3449104) /gene="narJ" /locus_tag="BSU_37260" /old_locus_tag="BSU37260" /label="narJ gene" CDS complement(3449130..3450593) /gene="narH" /locus_tag="BSU_37270" /old_locus_tag="BSU37270" /EC_number="1.7.99.4" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:7557333, 7860592, 8846791, 11289299, 15849754, 16850406, 22103536" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7557333, 7860592, 8846791, 11289299, 15849754, 16850406, 22103536; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nitrate reductase (beta subunit)" /protein_id="NP_391608.1" /db_xref="EnsemblGenomes-Gn:BSU37270" /db_xref="EnsemblGenomes-Tr:CAB15755" /db_xref="GOA:P42176" /db_xref="InterPro:IPR006547" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR029263" /db_xref="SubtiList:BG11082" /db_xref="UniProtKB/Swiss-Prot:P42176" /translation="MKIKAQIGMVMNLDKCIGCHTCSVTCKNTWTNRSGAEYMYFNNV ETKPGIGYPKQWEDQDKYKGGWTLKKGKLELKSGSKTNRLAGLFYNPNQPSIDDYYEP WNYDYETLTNSPQKKHQPVARPKSSLTGDFMNIEWGPNWEDDLAGGHITGLEDPNVQK MEESIKTEFDDVFMMYLPRICEHCINPACVSSCPSGAMYKREEDGIVLVDQNACRSWR YCVSSCPYKKVYFNWQTNKAEKCTLCFPRLEAGLPTICSETCVGRIRYLGVMLYDADK VEEAASVENEKDLYHSQLDVFLDPNDPEVAKLAKEQGIPAEWIEAAQQSPIYKMIIDW KIALPLHPEYRTLPMVWYIPPLSPIMNLFEGKGSRQTAEDIFPAIDQMRIPIDYLAQL LTAGDTDHIRSTLKKMSVMRQYMRAVQTNKSIDPELISSVGLTEQQIEDMYRLLAIAK YDDRFVIPSSHREEVSDLYAEQGSCGLSFSGGPGSCF*" /label="narH CDS" gene complement(3449130..3450593) /gene="narH" /locus_tag="BSU_37270" /old_locus_tag="BSU37270" /label="narH gene" CDS complement(3450583..3454269) /gene="narG" /locus_tag="BSU_37280" /old_locus_tag="BSU37280" /EC_number="1.7.5.1" /EC_number="1.7.99.4" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11289299, 7557333, 7860592, 8846791; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nitrate reductase (alpha subunit)" /protein_id="NP_391609.2" /db_xref="EnsemblGenomes-Gn:BSU37280" /db_xref="EnsemblGenomes-Tr:CAB15756" /db_xref="GOA:P42175" /db_xref="InterPro:IPR006468" /db_xref="InterPro:IPR006655" /db_xref="InterPro:IPR006656" /db_xref="InterPro:IPR006657" /db_xref="InterPro:IPR006963" /db_xref="InterPro:IPR009010" /db_xref="InterPro:IPR027467" /db_xref="InterPro:IPR028189" /db_xref="SubtiList:BG11081" /db_xref="UniProtKB/Swiss-Prot:P42175" /translation="MKKKKRSPLFRRLNYFSPIEHHSNKHSQTTREDRDWENVYRNRW QYDKVVRSTHGVNCTGSCSWNIYVKNGIVTWEGQNLNYPSTGPDMPDFEPRGCPRGAS FSWYIYSPLRVKYPYVRGVLINLWREALQTHQNPLEAWKSIVENPEKAKSYKQARGKG GFVRAEWPEVLKLISASLLYTVMKYGPDRNVGFSPIPAMSMISHASGSRFMSLIGGPM LSFYDWYADLPPASPQIWGDQTDVPESSDWYNSGYIITWGSNVPLTRTPDAHFLAEAR YKGAKVISISPDFAESSKFADDWLSIRQGTDGALAMAMGHVILQEFYVNQETERFIEY AKQYTDFPFLVTLSKENGVYTAGRFLHAKDIGRKTKHDQWKPAVWDEQTSSFAIPQGT MGSRWDGQQKWNLHMIDEETGEPIEPRLSVLGIEDEIGTVRIPYFSNDGNKVLERDLP IKKMNLNGEETYITTVFDLILANYGVNRGIGERSAVSYDDPEPFTPAWQEQMTGIKKE AVVKIAREFAQNAIDTDGRSMIIVGAGINHWFNSDTIYRAVLNLVLLVGAQGVNGGGW AHYVGQEKLRPAEGWQTIATAKDWEGVPKLQNGTSFFYFATDQWRYEDQPISDLASPI AASSRYKHHADYNVLAARLGWLPSYPTFNQNGIDLYKEAEKAGAATPEDVGAYVASQL QEKKLKFAIEDPDNEVNFPRNLFVWRANLISSSGKGHEYFLKHLLGTTNGLMNDDSDS IRPEEIKWREQAPEGKLDLLINLDFRMAGTALYSDIVLPAATWYEKHDLSSTDMHPFI HPFAPAISAPWESKSDWDIFKALSKAVSDLAEEVDMEPVKEVVATPLLHDTMQELAQP FGKINDWSKGECEAIPGKTMPNIQVVERDYKHIFHKMTALGPNVALKPSGTKGMSWSI ADEYESLKQRLGEITSDSVAKGCPNISEAKQAAEAILTLSSTSNGKVAVKAWESLENI TNLKLKDLAEEREEECFTFEQITAQPKTVITSPAFTGSEKGGRRYSPFTTNVEKLIPW RTLTGRQSYYVDHELMMEFGETMATFKPILQHRPFLSKRPDQEGKEIVLNYLTPHNKW SVHSMYFDSLPMLTLFRGGPTVWMNKDDAEDTDIKDNDWIECFNRNGVVVARAVLSHR IPKGMAFMHHAQDRHINVPGTKLTNNRGGTHNSPTRIHVKPTQMIGGYAQLSYGFNYY GPTGNQRDLNVVIRKLKEVDWLED*" /label="narG CDS" gene complement(3450583..3454269) /gene="narG" /locus_tag="BSU_37280" /old_locus_tag="BSU37280" /label="narG gene" misc_feature complement(3454300..3454319) /Source="Nicolas_upshift_promotors" /id="U2935" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.971028971028971" /psig="0.993006993006993" /xcortree=1614 /SigmaFactorBS="ctttgtgtgaacattttgtgaaaaaagcagagtgtgtgacat agttcacaaggaaacacgctgtcTCTGTTTATAGTGAACTTAGcatcacctgactcgg a" /listShort="narG, narH, narJ, narI, S1447" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3454324) /Source="Nicolas_upshifts" /id="U2935" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.971028971028971" /psig="0.993006993006993" /xcortree=1614 /SigmaFactorBS="ctttgtgtgaacattttgtgaaaaaagcagagtgtgtgacat agttcacaaggaaacacgctgtcTCTGTTTATAGTGAACTTAGcatcacctgactcgg a" /listShort="narG, narH, narJ, narI, S1447" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3454326..3454455) /Source="Nicolas_S_feature" /locus_tag="new_3830002_3830131_c" /HighExp="Lbtran, M40t45, LBGtran, ferm, M0t45, nit, S0, Lbstat, LBGstat, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1448" CDS complement(3454465..3454941) /gene="arfM" /locus_tag="BSU_37290" /old_locus_tag="BSU37290" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10809684, 11698370, 16428414, 22178965" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10809684, 11698370, 16428414, 22178965; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator" /protein_id="NP_391610.1" /db_xref="EnsemblGenomes-Gn:BSU37290" /db_xref="EnsemblGenomes-Tr:CAB15757" /db_xref="GOA:P46910" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR018490" /db_xref="SubtiList:BG11345" /db_xref="UniProtKB/Swiss-Prot:P46910" /translation="MNQCDYLLFLKQLPMFNEVPLSIVETLLKNGTFIRGSCDQSPSF LHSQSVYIVLKGSVRFMDTRLPEGSKTVALWEKGDVFPIDEKGGLYLSPFISVNATSD ILILNIPYYIFKKMMSYHPQLQMNFLAMLQQNVFCSYQLFLRYLHTSQDENAEPGS*" /label="arfM CDS" gene complement(3454465..3454941) /gene="arfM" /locus_tag="BSU_37290" /old_locus_tag="BSU37290" /label="arfM gene" downshifts complement(3454500) /Source="Nicolas_upshifts" /id="D1928" /incds=0 /nref=10 /ntot=39 /MaxReadThrough="5.03469" /MaxDrop="3.83412" /score="30.7487171" /energy="-10.5" /TU="U2936" /idTUdmin="U2936" /TUdmin="-154" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3454964..3454983) /Source="Nicolas_upshift_promotors" /id="U2936" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.72927072927073" /psig="0.996003996003996" /xcortree=1613 /SigmaFactorBS="aagtgacattcatcatacaggctgtgaaatacatcACTGctg tacaggctcagTCGAGCTACACTAAAGCTATccttagcacaggaggttttcctatgaa t" /listShort="arfM, S1448" /listLong="narG, narH, narJ, narI, S1447" /label="promotor_-10" upshifts complement(3454976) /Source="Nicolas_upshifts" /id="U2936" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.72927072927073" /psig="0.996003996003996" /xcortree=1613 /SigmaFactorBS="aagtgacattcatcatacaggctgtgaaatacatcACTGctg tacaggctcagTCGAGCTACACTAAAGCTATccttagcacaggaggttttcctatgaa t" /listShort="arfM, S1448" /listLong="narG, narH, narJ, narI, S1447" /label="upshifts" promotor_-35 complement(3454998..3455001) /Source="Nicolas_upshift_promotors" /id="U2936" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.72927072927073" /psig="0.996003996003996" /xcortree=1613 /SigmaFactorBS="aagtgacattcatcatacaggctgtgaaatacatcACTGctg tacaggctcagTCGAGCTACACTAAAGCTATccttagcacaggaggttttcctatgaa t" /listShort="arfM, S1448" /listLong="narG, narH, narJ, narI, S1447" /label="promotor_-35" upshifts 3455048 /Source="Nicolas_upshifts" /id="U2937" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=1612 /SigmaFactorBS="gcctgtacagcagtgatgtatttcacagcctgtatgatgaat gtcacttatcaggagggtgaaTGCATTTATAATGAAAGAAAaaaggaggatttcgatg a" /listShort="ywiC" /GFF_Attribute="listLong" /label="upshifts" misc_feature 3455051..3455070 /Source="Nicolas_upshift_promotors" /id="U2937" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=1612 /SigmaFactorBS="gcctgtacagcagtgatgtatttcacagcctgtatgatgaat gtcacttatcaggagggtgaaTGCATTTATAATGAAAGAAAaaaggaggatttcgatg a" /listShort="ywiC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 3455085..3455804 /gene="ywiC" /locus_tag="BSU_37300" /old_locus_tag="BSU37300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16428414, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391611.1" /db_xref="EnsemblGenomes-Gn:BSU37300" /db_xref="EnsemblGenomes-Tr:CAB15758" /db_xref="GOA:P46909" /db_xref="InterPro:IPR025576" /db_xref="SubtiList:BG11344" /db_xref="UniProtKB/Swiss-Prot:P46909" /translation="MKALIPKQHGAWAMLLIPFLLGMVKGGPVIWHIPLFLGWLFLYL AVYPVTLALKKKQSKPYQKWMCYYGFPTCCFLMISVFHKPPLIWVGVSLLPLFLIHMY FARRKNERALLNDVAGVLFFCSGGFASCWLGMGTLDGWAWFIFLQSALFFIGSSFYVK SVIRERKNRAFAYWSWGYHLLLPFLSALFGAGWAFLAFIPSSLRAWFFHGRDWPVKTI GILEIVNACFFLAVMCLFITR*" /label="ywiC CDS" gene 3455085..3455804 /gene="ywiC" /locus_tag="BSU_37300" /old_locus_tag="BSU37300" /label="ywiC gene" downshifts 3455788 /Source="Nicolas_upshifts" /id="D1929" /incds=0 /nref=14 /ntot=34 /MaxReadThrough="2.00369" /MaxDrop="5.63285" /score="-3.54009378" /energy="-5.8" /TU="NA" /idTUdmin="U2937" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3455836..3456552) /gene="fnr" /locus_tag="BSU_37310" /old_locus_tag="BSU37310" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8682783, 8846791, 16796679, 21068385, 23046954" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8682783, 8846791, 16796679, 21068385, 23046954; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of anaerobic metabolism (FNR/CAP family)" /protein_id="NP_391612.1" /db_xref="EnsemblGenomes-Gn:BSU37310" /db_xref="EnsemblGenomes-Tr:CAB15759" /db_xref="GOA:P46908" /db_xref="InterPro:IPR000595" /db_xref="InterPro:IPR012318" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR018335" /db_xref="InterPro:IPR018490" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11343" /db_xref="UniProtKB/Swiss-Prot:P46908" /translation="MNFLSVRPSDSDLISSDLYELLESISTKRKMEKHTYLFREGMDA EELYLIQSGLIEIGKLTSDGKDLTLRICQKHDIVGELTLFTEEPRYMLSAKVLEDGEV LVINKNKLEKELIQNGALTFEFMKWMSTHLRKIQSKIRDLLLHGKKGALYSTLIRLSN SYGVERSDGILINIVLTNQDLAKFCAAARESVNRMLGDLRKKGVISIDESGKIILHKR DYLRCEIECENCPLEICNID*" /label="fnr CDS" gene complement(3455836..3456552) /gene="fnr" /locus_tag="BSU_37310" /old_locus_tag="BSU37310" /label="fnr gene" downshifts complement(3455838) /Source="Nicolas_upshifts" /id="D1930" /incds=0 /nref=116 /ntot=238 /MaxReadThrough="3.06242" /MaxDrop="8.21489" /score="-2.80152808" /energy="-5.8" /TU="U2938,U2939" /idTUdmin="U2939" /TUdmin="-84" /isTUend="FALSE" /label="downshifts" downshifts complement(3455908) /Source="Nicolas_upshifts" /id="D1931" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="8.51297" /MaxDrop="3.71248" /score="-2.80152808" /energy="-5.8" /TU="U2938,U2939" /idTUdmin="U2939" /TUdmin="-154" /isTUend="FALSE" /label="downshifts" misc_feature complement(3456578..3456597) /Source="Nicolas_upshift_promotors" /id="U2938" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.556443556443556" /psig="0.999000999001" /xcortree=1623 /SigmaFactorBS="cactggggcattcacaagattgttagttttttctcgatgggt acaaatcaattCACGTTACAATAAACACACAacgtgactttcttcgaggtgagctcat g" /listShort="fnr" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3456590) /Source="Nicolas_upshifts" /id="U2938" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.556443556443556" /psig="0.999000999001" /xcortree=1623 /SigmaFactorBS="cactggggcattcacaagattgttagttttttctcgatgggt acaaatcaattCACGTTACAATAAACACACAacgtgactttcttcgaggtgagctcat g" /listShort="fnr" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3456651..3457838) /gene="narK" /locus_tag="BSU_37320" /old_locus_tag="BSU37320" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8682783, 8846791, 15849754, 16796679, 16850406, 26786044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8682783, 8846791, 15849754, 16796679, 16850406, 26786044; Product type t : transporter" /codon_start=1 /transl_table=11 /product="nitrite extrusion permease" /protein_id="NP_391613.2" /db_xref="EnsemblGenomes-Gn:BSU37320" /db_xref="EnsemblGenomes-Tr:CAB15760" /db_xref="GOA:P46907" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11342" /db_xref="UniProtKB/Swiss-Prot:P46907" /translation="MINRQHIQLSLQSLSLVAGFMVWVLISSLISQITLDIHLSKGEI SLVTAIPVILGSLLRIPLGYLTNRFGARLMFMVSFILLLFPVFWISIADSLFDLIAGG FFLGIGGAVFSIGVTSLPKYYPKEKHGVVNGIYGAGNIGTAVTTFAAPVIAQAVGWKS TVQMYLILLAVFALLHVLFGDRHEKKVKVSVKTQIKAVYRNHVLWFLSLFYFITFGAF VAFTIYLPNFLVEHFGLNPADAGLRTAGFIAVSTLLRPAGGFLADKMSPLRILMFVFA GLTLSGIILSFSPTIGLYTFGSLTVAVCSGIGNGTVFKLVPFYFSKQAGIANGIVSAM GGLGGFFPPLILASVFQATGQYAIGFMALSEVALASFVLVIWMYWQERMKTHTERNSQ SIN*" /label="narK CDS" gene complement(3456651..3457838) /gene="narK" /locus_tag="BSU_37320" /old_locus_tag="BSU37320" /label="narK gene" misc_feature complement(3457868..3457887) /Source="Nicolas_upshift_promotors" /id="U2939" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.982017982017982" /psig="0.998001998001998" /xcortree=1615 /SigmaFactorBS="gctttgtcctttttttatgagaaaaacgtgtgatgtaattca caatcctgtttggctagTTTTTGTATGATAAGACTGAttattgaatcattgaaagggg c" /listShort="narK, fnr" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3457886) /Source="Nicolas_upshifts" /id="U2939" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.982017982017982" /psig="0.998001998001998" /xcortree=1615 /SigmaFactorBS="gctttgtcctttttttatgagaaaaacgtgtgatgtaattca caatcctgtttggctagTTTTTGTATGATAAGACTGAttattgaatcattgaaagggg c" /listShort="narK, fnr" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3457974..3459644) /gene="argS" /locus_tag="BSU_37330" /old_locus_tag="BSU37330" /EC_number="6.1.1.19" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8289305, 9862121" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8289305, 9862121; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arginyl-tRNA synthetase" /protein_id="NP_391614.1" /db_xref="EnsemblGenomes-Gn:BSU37330" /db_xref="EnsemblGenomes-Tr:CAB15761" /db_xref="GOA:P46906" /db_xref="InterPro:IPR001278" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR005148" /db_xref="InterPro:IPR008909" /db_xref="InterPro:IPR009080" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR035684" /db_xref="InterPro:IPR036695" /db_xref="SubtiList:BG11341" /db_xref="UniProtKB/Swiss-Prot:P46906" /translation="MNIAEQMKDVLKEEIKAAVLKAGLAEESQIPNVVLETPKDKTHG DYSTNMAMQLARVAKKAPRQIAEEIVAHFDKGKASIEKLDIAGPGFINFYMNNQYLTK LIPSVLEAGEAYGETNIGNGERVQVEFVSANPTGDLHLGHARGAAVGDSLCNVLSKAG YDVSREYYINDAGNQINNLALSVEVRYFEALGLEKPMPEDGYRGEDIIAIGKRLAEEY GDRFVNEEESERLAFFREYGLKYELEKLRKDLENFRVPFDVWYSETSLYQNGKIDKAL EALREKGHVYEEDGATWFRSTTFGDDKDRVLIKKDGTYTYLLPDIAYHKDKLDRGFDK LINVWGADHHGYIPRMKAAIEALGYEKGTLEVEIIQLVHLYKNGEKMKMSKRTGKAVT MRDLIEEVGLDAVRYFFAMRSADTHMDFDLDLAVSTSNENPVYYAQYAHARICSMLRQ GEEQGLKPAADLDFSHIQSEKEYDLLKTIGGFPEAVAEAAEKRIPHRVTNYIYDLASA LHSFYNAEKVIDPENEEKSRARLALMKATQITLNNALQLIGVSAPEKM*" /label="argS CDS" gene complement(3457974..3459644) /gene="argS" /locus_tag="BSU_37330" /old_locus_tag="BSU37330" /label="argS gene" downshifts complement(3457976) /Source="Nicolas_upshifts" /id="D1932" /incds=0 /nref=252 /ntot=266 /MaxReadThrough="1.71727" /MaxDrop="6.56513" /score="23.3947976" /energy="-12.5" /TU="NA" /idTUdmin="U2941" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3459641..3460069) /gene="ywiB" /locus_tag="BSU_37340" /old_locus_tag="BSU37340" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative RNA binding protein" /protein_id="NP_391615.1" /db_xref="EnsemblGenomes-Gn:BSU37340" /db_xref="EnsemblGenomes-Tr:CAB15762" /db_xref="InterPro:IPR012674" /db_xref="InterPro:IPR015231" /db_xref="PDB:1R0U" /db_xref="SubtiList:BG14161" /db_xref="UniProtKB/Swiss-Prot:O07624" /translation="MKQETPITLHVKSVIEDDGNQEVIEFRTTGFYYVKQNKVYLSYY EEHDLGKVKTIVKVSEGEVLVMRSGAVKMNQRFVTGASTIAKYKMSFGELELKTSTKS IQSDLDEEKGRISIAYDMHVGDEQEHLHNMTITYEGGTHA*" /label="ywiB CDS" gene complement(3459641..3460069) /gene="ywiB" /locus_tag="BSU_37340" /old_locus_tag="BSU37340" /label="ywiB gene" misc_feature 3460137..3460151 /Source="Nicolas_upshift_promotors" /id="U2940" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.911088911088911" /psig="0.056943056943057" /xcortree=297 /SigmaFactorBS="ttcatcattccactttgacttgaatagtataatcattcggtt tgtaaacttcaACTGCTTCTATCTTAccatcattgctcatcagatttgaagataaacc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(3460137..3460156) /Source="Nicolas_upshift_promotors" /id="U2941" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.53946053946054" /psig=1 /xcortree=2566 /SigmaFactorBS="ctcttctatataaggaaatgctttttatgaggtttatCTTCa aatctgatgagcaatGATGGTAAGATAGAAGCAGTtgaagtttacaaaccgaatgatt a" /listShort="ywiB, argS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3460144 /Source="Nicolas_upshifts" /id="U2940" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.911088911088911" /psig="0.056943056943057" /xcortree=297 /SigmaFactorBS="ttcatcattccactttgacttgaatagtataatcattcggtt tgtaaacttcaACTGCTTCTATCTTAccatcattgctcatcagatttgaagataaacc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3460153) /Source="Nicolas_upshifts" /id="U2941" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.53946053946054" /psig=1 /xcortree=2566 /SigmaFactorBS="ctcttctatataaggaaatgctttttatgaggtttatCTTCa aatctgatgagcaatGATGGTAAGATAGAAGCAGTtgaagtttacaaaccgaatgatt a" /listShort="ywiB, argS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3460173..3460176) /Source="Nicolas_upshift_promotors" /id="U2941" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.53946053946054" /psig=1 /xcortree=2566 /SigmaFactorBS="ctcttctatataaggaaatgctttttatgaggtttatCTTCa aatctgatgagcaatGATGGTAAGATAGAAGCAGTtgaagtttacaaaccgaatgatt a" /listShort="ywiB, argS" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(3460208..3460227) /Source="Nicolas_upshift_promotors" /id="U2942" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.802197802197802" /psig="0.932067932067932" /xcortree=1621 /SigmaFactorBS="gtgaaaaggaaatgatagatttcggaaaaatgtaacatttcc taaaggtaattAGTGATATGATTTTCTCTTCtatataaggaaatgctttttatgaggt t" /GFF_Attribute="listShort" /listLong="ywiB, argS" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3460220) /Source="Nicolas_upshifts" /id="U2942" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.802197802197802" /psig="0.932067932067932" /xcortree=1621 /SigmaFactorBS="gtgaaaaggaaatgatagatttcggaaaaatgtaacatttcc taaaggtaattAGTGATATGATTTTCTCTTCtatataaggaaatgctttttatgaggt t" /GFF_Attribute="listShort" /listLong="ywiB, argS" /label="upshifts" SCAR join(3460249,3460256) /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs09" N_region 3460250..3460255 /note="SacI site (GAGCTC)" /created_by="User" /modified_by="User" /label="IIG_Bs09" S_feature <3460256..3462734 /Source="Nicolas_S_feature" /locus_tag="new_3842996_3845478" /HighExp="Lbstat, nit, ferm, BI, M0t90, S2, M40t90, BT, M0t45, GM 150" /AntisenseName="ywhL" /AntisenseCor="7.7827453562424306E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.99, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1450" CDS complement(3460257..3461633) /gene="ywhL" /locus_tag="BSU_37440" /old_locus_tag="BSU37440" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12073041" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391624.1" /db_xref="EnsemblGenomes-Gn:BSU37440" /db_xref="EnsemblGenomes-Tr:CAB15771" /db_xref="InterPro:IPR011045" /db_xref="InterPro:IPR015943" /db_xref="SubtiList:BG12464" /db_xref="UniProtKB/Swiss-Prot:P71004" /translation="MKKNDLSALQENCFCFCDEEISREAPFQVPIDFPEGFKVDTAEA SAAVTWSTDNLSCISEPCLIQTGPEPEDIGVRYAVRVQGTITLLVSVSPVRNQYGQGD GAVSVIHTEEIDQVVYYAAQSGRCPDFSQITVEDLLIVPPFYGSPLTVAGTLVLPPSP DPQSYVFTANTGDSTVSVIDADLNTVVKTIPFSDVPTNLGVTFDKAFTYVLHGNTNLV SVIDNKTLTIINTITVGGGPRKIEFDPTDEFAYVMAAGSIYVINTASQSVIDVIPIPG ALDFALDPNGQYVYTANGSSWSVDKYDVNTGQLVESIIDTFEFPSLITTPYAGNFAYV LNGELWPKGVTEISLSPLSRGGDFSRLFETLRTIVFSLDSTRAYFLEPYSEPFLINNL YVVNTARQRIIANVSLPGAFDLAVTPDKQYIYAAQPNDNAVTVYRTSDYTAVTVIPVG AGPSAIAM*" /label="ywhL CDS" gene complement(3460257..3461633) /gene="ywhL" /locus_tag="BSU_37440" /old_locus_tag="BSU37440" /label="ywhL gene" CDS complement(3461672..3463027) /gene="ywhK" /locus_tag="BSU_37450" /old_locus_tag="BSU37450" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12073041" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12073041; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor interacting with DNA helicase PcrA" /protein_id="NP_391625.1" /db_xref="EnsemblGenomes-Gn:BSU37450" /db_xref="EnsemblGenomes-Tr:CAB15772" /db_xref="InterPro:IPR011045" /db_xref="InterPro:IPR015943" /db_xref="SubtiList:BG12463" /db_xref="UniProtKB/Swiss-Prot:P71003" /translation="MRKNKLSFKEKAGAEQEECLCFCEGEASREAMFQAPIELPEGFV VDPAEAVANVTWNADSLSCVSDRCLIQTGPEPDEVGVQFAVRLQGTVTLLVSVSPVRN QYGQGDGAVSVIHNAEIDQVVYYSDESDDCPDISDITIENLVVVPPFYGSPLSVTGTI VLVPEPEPVYAFTANPNDQSVSVIDTNTDTVVTTIALPYNPAGIEITPDKSAVFVLHP NNNVISVIDYDTLTVTATILLDQPPRLIRFIPNHEFAYVFTGTAVYVIGIDTLTVDRS IPVEGYDVAIDPNGLFAYVLNFGIVQKVDLTTGEVTGTIERELIVSTIETNWPERYAY VLEQEFFFNYLTVIDLNTFTISSTQELEYEGEYRMFTSGAEVYLYDGFTGNLYSVSPN GAGVIGNVPQSATDYAFTPNGDFLYATRFIEQSIIVYNTDDYSEETVISLGVSPGAIT I*" /label="ywhK CDS" gene complement(3461672..3463027) /gene="ywhK" /locus_tag="BSU_37450" /old_locus_tag="BSU37450" /label="ywhK gene" promotor_-10 complement(3463063..3463082) /Source="Nicolas_upshift_promotors" /id="U2945" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1430 /SigmaFactorBS="tatattttcaaaaagaagcgtttaccctcagcaatttGTACA AGCAAacacgttaccctTCCATATTCTGTTATATCTGcgtgagcagtgtatgtctgaa a" /listShort="ywhK, ywhL, S1449" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3463081) /Source="Nicolas_upshifts" /id="U2945" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1430 /SigmaFactorBS="tatattttcaaaaagaagcgtttaccctcagcaatttGTACA AGCAAacacgttaccctTCCATATTCTGTTATATCTGcgtgagcagtgtatgtctgaa a" /listShort="ywhK, ywhL, S1449" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3463095..3463104) /Source="Nicolas_upshift_promotors" /id="U2945" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1430 /SigmaFactorBS="tatattttcaaaaagaagcgtttaccctcagcaatttGTACA AGCAAacacgttaccctTCCATATTCTGTTATATCTGcgtgagcagtgtatgtctgaa a" /listShort="ywhK, ywhL, S1449" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 3463207..3463226 /Source="Nicolas_upshift_promotors" /id="U2946" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.899100899100899" /psig="0.921078921078921" /xcortree=683 /SigmaFactorBS="aacatgcggtgtaacgaaagaaaaaattgcggtttttttgcg cttctcacaagaatgttGATGATAAAATATGACATATatagaattatgaagggaggga t" /listShort="rapF, phrF, S1451, ywhH" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3463208 /Source="Nicolas_upshifts" /id="U2946" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.899100899100899" /psig="0.921078921078921" /xcortree=683 /SigmaFactorBS="aacatgcggtgtaacgaaagaaaaaattgcggtttttttgcg cttctcacaagaatgttGATGATAAAATATGACATATatagaattatgaagggaggga t" /listShort="rapF, phrF, S1451, ywhH" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(3463253) /Source="Nicolas_upshifts" /id="D1937" /incds=0 /nref=7 /ntot=59 /MaxReadThrough="2.35357" /MaxDrop="4.85842" /score="29.5788849" /energy="-11.3" /TU="NA" /idTUdmin="U2948" /TUdmin=1867 /isTUend="FALSE" /label="downshifts" CDS 3463257..3464402 /gene="rapF" /locus_tag="BSU_37460" /old_locus_tag="BSU37460" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15968044, 16816200, 23526880" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15968044, 16816200, 23526880; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="response regulator aspartate phosphatase anti-activator of ComA" /protein_id="NP_391626.1" /db_xref="EnsemblGenomes-Gn:BSU37460" /db_xref="EnsemblGenomes-Tr:CAB15773" /db_xref="GOA:P71002" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="PDB:3ULQ" /db_xref="PDB:4I9C" /db_xref="PDB:4I9E" /db_xref="SubtiList:BG11968" /db_xref="UniProtKB/Swiss-Prot:P71002" /translation="MTGVISSSSIGEKINEWYMYIRRFSIPDAEYLRREIKQELDQME EDQDLHLYYSLMEFRHNLMLEYLEPLEKMRIEEQPRLSDLLLEIDKKQARLTGLLEYY FNFFRGMYELDQREYLSAIKFFKKAESKLIFVKDRIEKAEFFFKMSESYYYMKQTYFS MDYARQAYEIYKEHEAYNIRLLQCHSLFATNFLDLKQYEDAISHFQKAYSMAEAEKQP QLMGRTLYNIGLCKNSQSQYEDAIPYFKRAIAVFEESNILPSLPQAYFLITQIHYKLG KIDKAHEYHSKGMAYSQKAGDVIYLSEFEFLKSLYLSGPDEEAIQGFFDFLESKMLYA DLEDFAIDVAKYYHERKNFQKASAYFLKVEQVRQLIQGGVSLYEIEV*" /label="rapF CDS" gene 3463257..3464402 /gene="rapF" /locus_tag="BSU_37460" /old_locus_tag="BSU37460" /label="rapF gene" promotor_-35 3464261..3464265 /Source="Nicolas_upshift_promotors" /id="U2947" /multdbtbs="SigH" /comp="M16" /sig="SigA" /pcomp="0.585414585414585" /psig="0.986013986013986" /xcortree=751 /SigmaFactorBS="gattttctcgaaagtaaaatgttgtatgctgaTCTTGaagat ttcgctattgaTGTGGCAAAATATTATCATGaacgtaaaaattttcaaaaagcttctg c" /listShort="phrF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3464282..3464301 /Source="Nicolas_upshift_promotors" /id="U2947" /multdbtbs="SigH" /comp="M16" /sig="SigA" /pcomp="0.585414585414585" /psig="0.986013986013986" /xcortree=751 /SigmaFactorBS="gattttctcgaaagtaaaatgttgtatgctgaTCTTGaagat ttcgctattgaTGTGGCAAAATATTATCATGaacgtaaaaattttcaaaaagcttctg c" /listShort="phrF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3464289 /Source="Nicolas_upshifts" /id="U2947" /multdbtbs="SigH" /comp="M16" /sig="SigA" /pcomp="0.585414585414585" /psig="0.986013986013986" /xcortree=751 /SigmaFactorBS="gattttctcgaaagtaaaatgttgtatgctgaTCTTGaagat ttcgctattgaTGTGGCAAAATATTATCATGaacgtaaaaattttcaaaaagcttctg c" /listShort="phrF" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(3464372) /Source="Nicolas_upshifts" /id="D1938" /incds=0 /nref=1 /ntot=59 /MaxReadThrough="1.70728" /MaxDrop="2.74755" /score="29.5788849" /energy="-11.3" /TU="NA" /idTUdmin="U2948" /TUdmin=748 /isTUend="FALSE" /label="downshifts" CDS 3464386..3464505 /gene="phrF" /locus_tag="BSU_37470" /old_locus_tag="BSU37470" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15968044, 16816200, 23526880" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15968044, 16816200, 23526880; Product type f: factor" /codon_start=1 /transl_table=11 /product="secreted regulator of the activity of phosphatase RapF" /protein_id="NP_391627.1" /db_xref="EnsemblGenomes-Gn:BSU37470" /db_xref="EnsemblGenomes-Tr:CAB15774" /db_xref="GOA:P71001" /db_xref="InterPro:IPR025899" /db_xref="SubtiList:BG11960" /db_xref="UniProtKB/Swiss-Prot:P71001" /translation="MKLKSKLLLSCLALSTVFVATTIANAPTHQIEVAQRGMI*" /label="phrF CDS" gene 3464386..3464505 /gene="phrF" /locus_tag="BSU_37470" /old_locus_tag="BSU37470" /label="phrF gene" downshifts 3464490 /Source="Nicolas_upshifts" /id="D1939" /incds=0 /nref=240 /ntot=268 /MaxReadThrough="5.48985" /MaxDrop="6.14096" /score="19.6493244" /energy="-9.9" /TU="U2946" /idTUdmin="U2947" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" S_feature 3464535..3464603 /Source="Nicolas_S_feature" /locus_tag="new_3847279_3847347" /HighExp="S2, S3, S4, S5, S6, S1, BT, S7, S8, Fru" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.921" /TUlongSig="NA" /TUlongPSig="NA" /label="S1451" CDS 3464604..3465077 /gene="ywhH" /locus_tag="BSU_37480" /old_locus_tag="BSU37480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative tRNA editing enzyme" /protein_id="NP_391628.1" /db_xref="EnsemblGenomes-Gn:BSU37480" /db_xref="EnsemblGenomes-Tr:CAB15775" /db_xref="GOA:P71000" /db_xref="InterPro:IPR007214" /db_xref="InterPro:IPR036754" /db_xref="SubtiList:BG12462" /db_xref="UniProtKB/Swiss-Prot:P71000" /translation="MSLKSVRTHFTQWNRENDVTEFETSSATVEQAAETIGVSLSRIA KSLSFRGEGDQVILIVAAGDAKIDNKKSRQTFGFKARMLSPNEVLEQTGHEIGGVCPF GLAHDPEVYLDVSLKRFQTVFPACGSRNSAIELTPKELSEFSFSKVWIDVCKDWE*" /label="ywhH CDS" gene 3464604..3465077 /gene="ywhH" /locus_tag="BSU_37480" /old_locus_tag="BSU37480" /label="ywhH gene" downshifts 3465066 /Source="Nicolas_upshifts" /id="D1940" /incds=0 /nref=30 /ntot=156 /MaxReadThrough="2.85314" /MaxDrop="4.40065" /score="-6.80415499" /energy="-11.3" /TU="NA" /idTUdmin="U2946" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3465109..3465981) /gene="speB" /locus_tag="BSU_37490" /old_locus_tag="BSU37490" /EC_number="3.5.3.11" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9723923, 10931887, 24678831, 28807600, 28291380" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9723923, 10931887, 24678831, 28807600, 28291380; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="agmatinase" /protein_id="NP_391629.1" /db_xref="EnsemblGenomes-Gn:BSU37490" /db_xref="EnsemblGenomes-Tr:CAB15776" /db_xref="GOA:P70999" /db_xref="InterPro:IPR005925" /db_xref="InterPro:IPR006035" /db_xref="InterPro:IPR020855" /db_xref="InterPro:IPR023696" /db_xref="SubtiList:BG12461" /db_xref="UniProtKB/Swiss-Prot:P70999" /translation="MRFDEAYSGKVFIASRPEWEEADAILYGMPMDWTVSYRPGSRFG PSRIREVSIGLEEYSPYLDRDLADLNFFDAGDIPLPFGNPQRSLDMIEEYVDSILEKG KFPMGMGGEHLVSWPVIKAMYKKYPDLAIIHFDAHTDLRVDYEGEPLSHSTPIRKAAE LIGPHNVYSFGIRSGMKEEFEWAKENGMHISKFEVLEPLKEVLPKLAGRPVYVTIDID VLDPAHAPGTGTVDAGGITSKELLASVHEIARSEVNVKGADLVEVAPVYDHSEQTANT ASKIIREMLLGFVK*" /label="speB CDS" gene complement(3465109..3465981) /gene="speB" /locus_tag="BSU_37490" /old_locus_tag="BSU37490" /label="speB gene" downshifts complement(3465120) /Source="Nicolas_upshifts" /id="D1941" /incds=0 /nref=49 /ntot=171 /MaxReadThrough="2.5482" /MaxDrop="5.46925" /score="29.5788849" /energy="-11.3" /TU="NA" /idTUdmin="U2948" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(3465186) /Source="Nicolas_upshifts" /id="D1942" /incds=1 /nref=8 /ntot=50 /MaxReadThrough="5.83631" /MaxDrop="3.87062" /score="29.5788849" /energy="-11.3" /TU="U2948" /idTUdmin="U2948" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" CDS complement(3466042..3466872) /gene="speE" /locus_tag="BSU_37500" /old_locus_tag="BSU37500" /EC_number="2.5.1.16" /function="16.3: Control" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9723923, 26735940, 28546427, 28807600" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9723923, 26735940, 28546427, 28807600; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spermidine synthase; polyamine metabolism" /protein_id="NP_391630.1" /db_xref="EnsemblGenomes-Gn:BSU37500" /db_xref="EnsemblGenomes-Tr:CAB15777" /db_xref="GOA:P70998" /db_xref="InterPro:IPR001045" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR030373" /db_xref="InterPro:IPR030374" /db_xref="InterPro:IPR035246" /db_xref="InterPro:IPR037163" /db_xref="PDB:1IY9" /db_xref="SubtiList:BG12460" /db_xref="UniProtKB/Swiss-Prot:P70998" /translation="MSELWYTEKQTKNFGITMKVNKTLHTEQTEFQHLEMVETEEFGN MLFLDGMVMTSEKDEFVYHEMVAHVPLFTHPNPEHVLVVGGGDGGVIREILKHPSVKK ATLVDIDGKVIEYSKKFLPSIAGKLDDPRVDVQVDDGFMHIAKSENQYDVIMVDSTEP VGPAVNLFTKGFYAGIAKALKEDGIFVAQTDNPWFTPELITNVQRDVKEIFPITKLYT ANIPTYPSGLWTFTIGSKKYDPLAVEDSRFFDIETKYYTKDIHKAAFVLPKFVSDLIK *" /label="speE CDS" gene complement(3466042..3466872) /gene="speE" /locus_tag="BSU_37500" /old_locus_tag="BSU37500" /label="speE gene" S_feature complement(3466873..3466968) /Source="Nicolas_S_feature" /locus_tag="new_3849617_3849712_c" /HighExp="Paraq, G180, Oxctl, H2O2, LBGexp, G150, G135, C30, dia15, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S1452" promotor_-10 complement(3466956..3466975) /Source="Nicolas_upshift_promotors" /id="U2948" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.523476523476524" /psig="0.988011988011988" /xcortree=2546 /SigmaFactorBS="gatcgtttttaaacatcgcagaacaggacgcaTCTTTACTtt ttccccgccaTCCTCTATACTTTTTCCTTAggtgaaaatgagatttcaaccgagaata a" /listShort="S1452, speE, speB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3466967) /Source="Nicolas_upshifts" /id="U2948" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.523476523476524" /psig="0.988011988011988" /xcortree=2546 /SigmaFactorBS="gatcgtttttaaacatcgcagaacaggacgcaTCTTTACTtt ttccccgccaTCCTCTATACTTTTTCCTTAggtgaaaatgagatttcaaccgagaata a" /listShort="S1452, speE, speB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3466988..3466995) /Source="Nicolas_upshift_promotors" /id="U2948" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.523476523476524" /psig="0.988011988011988" /xcortree=2546 /SigmaFactorBS="gatcgtttttaaacatcgcagaacaggacgcaTCTTTACTtt ttccccgccaTCCTCTATACTTTTTCCTTAggtgaaaatgagatttcaaccgagaata a" /listShort="S1452, speE, speB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3467013..3467018 /Source="Nicolas_upshift_promotors" /id="U2949" /multdbtbs="SigF,SigG" /comp="M3" /sig="SigEF" /pcomp="0.758241758241758" /psig="0.758241758241758" /xcortree=1076 /SigmaFactorBS="tggcggggaaaaagtaaagatgcgtcctgttctgcgaTGTTT AaaaacgatcttttttTCTCATAATAGTAGAAACAtaaaaaaagggggaacccgttgt g" /listShort="pbpG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3467034..3467052 /Source="Nicolas_upshift_promotors" /id="U2949" /multdbtbs="SigF,SigG" /comp="M3" /sig="SigEF" /pcomp="0.758241758241758" /psig="0.758241758241758" /xcortree=1076 /SigmaFactorBS="tggcggggaaaaagtaaagatgcgtcctgttctgcgaTGTTT AaaaacgatcttttttTCTCATAATAGTAGAAACAtaaaaaaagggggaacccgttgt g" /listShort="pbpG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3467036 /Source="Nicolas_upshifts" /id="U2949" /multdbtbs="SigF,SigG" /comp="M3" /sig="SigEF" /pcomp="0.758241758241758" /psig="0.758241758241758" /xcortree=1076 /SigmaFactorBS="tggcggggaaaaagtaaagatgcgtcctgttctgcgaTGTTT AaaaacgatcttttttTCTCATAATAGTAGAAACAtaaaaaaagggggaacccgttgt g" /listShort="pbpG" /GFF_Attribute="listLong" /label="upshifts" CDS 3467074..3469149 /gene="pbpG" /locus_tag="BSU_37510" /old_locus_tag="BSU37510" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10767540, 11567005" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10767540, 11567005; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sporulation specific penicillin-binding protein 2D" /protein_id="NP_391631.2" /db_xref="EnsemblGenomes-Gn:BSU37510" /db_xref="EnsemblGenomes-Tr:CAB15778" /db_xref="GOA:P70997" /db_xref="InterPro:IPR001264" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR023346" /db_xref="InterPro:IPR036950" /db_xref="SubtiList:BG12459" /db_xref="UniProtKB/Swiss-Prot:P70997" /translation="MDAMTNKRLRLTLKTVRAFIFLGAFAALAAAAVFMTVILIAKYQ GAPSVQVPQSTILYASDGSKLGETNYGEKRYWVPLKDMNPTIVKATVAIEDQNFYDHH GFDYKRMAGAALADLKAFAKVQGASTITQQYARNLYLEHDKTWKRKWNEAFYTIRLEQ NYSKDEILEGYLNTIYYGHGAYGIEAASRLYFGKHAKNLTDAEAALLAGIPKGPSGYS PYVNETKAKERQKTIVRMMEKQQMISQKKADELIKEPLSYQPLNKQVSKRKAPYFYDN AMRELEKKLGMTREQIETSGLNVYTTVDKRMQRIAEETITETVNAGSDIQVGFSAIDP RTGNVLALVGGRDYQKSPFDRTTQAKRQPASTIKPLLYYKAIQSGFTPVTLMKSEETE FQIDAKGETYSPSNYNGYYANKPITLLQALALSDNIYAVKTHLFLGTNKLVKTAKEFG ITAHLQALPSLALGTEPVRPIEMVNAYAMLANGGKKIEPTFISRVTDAAGHVLYENPN QHKQVLDEKAAFVTASMMTGMFDIDLNGYTSVTGRTIANRLTRTYAGKSGTTSADSWM IGFNPKLAAGVWTGYDKNSTIDSVEEKSYAKTIWADFMEDALKGEPETAFKPPKGVTG VYIDPETGYSSGPGCAAKHYTYFVKGTEPANVCYGAEPAKQTKDRLPSKEKPASEKKW WDKWLGRHH*" /label="pbpG CDS" gene 3467074..3469149 /gene="pbpG" /locus_tag="BSU_37510" /old_locus_tag="BSU37510" /label="pbpG gene" downshifts complement(3469202) /Source="Nicolas_upshifts" /id="D1943" /incds=0 /nref=2 /ntot=122 /MaxReadThrough="1.43573" /MaxDrop="3.61075" /score="-7.59753556" /energy="-10.7" /TU="NA" /idTUdmin="U2951" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" S_feature complement(3469326..3469441) /Source="Nicolas_S_feature" /locus_tag="new_3852070_3852185_c" /HighExp="Sw, C90, BI, dia5, dia15, Diami, LBGexp, M0t45, Lbexp, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1453" downshifts complement(3469369) /Source="Nicolas_upshifts" /id="D1944" /incds=0 /nref=198 /ntot=248 /MaxReadThrough="3.25498" /MaxDrop="6.4287" /score="-7.59753556" /energy="-10.7" /TU="U2951,U2952" /idTUdmin="U2952" /TUdmin="-156" /isTUend="FALSE" /label="downshifts" CDS complement(3469442..3469960) /gene="ywhD" /locus_tag="BSU_37520" /old_locus_tag="BSU37520" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391632.1" /db_xref="EnsemblGenomes-Gn:BSU37520" /db_xref="EnsemblGenomes-Tr:CAB15779" /db_xref="InterPro:IPR014852" /db_xref="SubtiList:BG12458" /db_xref="UniProtKB/Swiss-Prot:P70996" /translation="MEEKKKKSIGFNIIKSDPTDGHGGFGVGALSLDNISPVFVDVEE KEAFVDIGAMHARSTVEKGIKFLPNKEEVPNGKPYWLVWVTIDRKEEGPYYAGVTACE MTVDRSIRRGYKSLPEHVNLMDKSMKRKIIVDKMDDSSKRVLGEFLKKHDQGLWDRSS DELKTSLLPENN*" /label="ywhD CDS" gene complement(3469442..3469960) /gene="ywhD" /locus_tag="BSU_37520" /old_locus_tag="BSU37520" /label="ywhD gene" CDS complement(3469974..3470633) /gene="ywhC" /locus_tag="BSU_37530" /old_locus_tag="BSU37530" /EC_number="3.4.24.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 25649915; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent hydrolase; integral membrane protein" /protein_id="NP_391633.1" /db_xref="EnsemblGenomes-Gn:BSU37530" /db_xref="EnsemblGenomes-Tr:CAB15780" /db_xref="GOA:P70995" /db_xref="InterPro:IPR008915" /db_xref="SubtiList:BG12457" /db_xref="UniProtKB/Swiss-Prot:P70995" /translation="MDRFLYYPLSLMPYLVITLIVSFTMHELAHAYVAYKFGDDTAKK QGRLTLNPIKHLDPFGTILILVAGFGWARPIPVNRRFFKKPRLAGVLVSIAGPVSNLI LAFIGFFLLVLMHAYGMEMLAAFSTGLDQFFSIWIQLNLVLFLFNLLPLPPLDGYRII EDLVPPGVRAKMTQAESYGFIVFLVLFVTPLGSYVLWPMLNAGRDSILKLFSAIFQPL L*" /label="ywhC CDS" gene complement(3469974..3470633) /gene="ywhC" /locus_tag="BSU_37530" /old_locus_tag="BSU37530" /label="ywhC gene" promotor_-35 3470656..3470659 /Source="Nicolas_upshift_promotors" /id="U2950" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.919080919080919" /psig="0.993006993006993" /xcortree=2205 /SigmaFactorBS="tataaaaaacggtccaagtgagatatccctctttctcaaAAT GcaagaatttactttATTCAGTATACTATAAGAAGcctctttttctaaagagaggaaa c" /listShort="ywhB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3470669..3470688) /Source="Nicolas_upshift_promotors" /id="U2951" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.549450549450549" /psig=1 /xcortree=1882 /SigmaFactorBS="tggcatgggtgctgaatcctcctttatctcgtttcctCTCTT TAGaaaaagaggcttctTATAGTATACTGAATAAAGTaaattcttgcattttgagaaa g" /listShort="ywhC, ywhD, S1453" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 3470674..3470693 /Source="Nicolas_upshift_promotors" /id="U2950" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.919080919080919" /psig="0.993006993006993" /xcortree=2205 /SigmaFactorBS="tataaaaaacggtccaagtgagatatccctctttctcaaAAT GcaagaatttactttATTCAGTATACTATAAGAAGcctctttttctaaagagaggaaa c" /listShort="ywhB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3470677 /Source="Nicolas_upshifts" /id="U2950" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.919080919080919" /psig="0.993006993006993" /xcortree=2205 /SigmaFactorBS="tataaaaaacggtccaagtgagatatccctctttctcaaAAT GcaagaatttactttATTCAGTATACTATAAGAAGcctctttttctaaagagaggaaa c" /listShort="ywhB" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3470687) /Source="Nicolas_upshifts" /id="U2951" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.549450549450549" /psig=1 /xcortree=1882 /SigmaFactorBS="tggcatgggtgctgaatcctcctttatctcgtttcctCTCTT TAGaaaaagaggcttctTATAGTATACTGAATAAAGTaaattcttgcattttgagaaa g" /listShort="ywhC, ywhD, S1453" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3470689..3470972) /Source="Nicolas_S_feature" /locus_tag="new_3853433_3853716_c" /HighExp="Diami, dia5, dia15, C90, Etha, Sw, H2O2, G135, M40t45, Lbtran" /AntisenseName="ywhB" /AntisenseCor="0.10541372702249199" /AntisenseRegPval="-1.1000000000000001" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1454" promotor_-35 complement(3470703..3470710) /Source="Nicolas_upshift_promotors" /id="U2951" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.549450549450549" /psig=1 /xcortree=1882 /SigmaFactorBS="tggcatgggtgctgaatcctcctttatctcgtttcctCTCTT TAGaaaaagaggcttctTATAGTATACTGAATAAAGTaaattcttgcattttgagaaa g" /listShort="ywhC, ywhD, S1453" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3470742..3470930 /gene="hmtB" /locus_tag="BSU_37540" /old_locus_tag="BSU37540" /EC_number="5.3.2.6" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12051677, 14624569, 14730980, 15301547, 17902707" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12051677, 14624569, 14730980, 15301547, 17902707; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-hydroxymuconate tautomerase (promiscuous)" /protein_id="NP_391634.1" /db_xref="EnsemblGenomes-Gn:BSU37540" /db_xref="EnsemblGenomes-Tr:CAB15781" /db_xref="GOA:P70994" /db_xref="InterPro:IPR004370" /db_xref="InterPro:IPR014347" /db_xref="InterPro:IPR018191" /db_xref="PDB:2OP8" /db_xref="PDB:2OPA" /db_xref="SubtiList:BG12456" /db_xref="UniProtKB/Swiss-Prot:P70994" /translation="MPYVTVKMLEGRTDEQKRNLVEKVTEAVKETTGASEEKIVVFIE EMRKDHYAVAGKRLSDME*" /label="hmtB CDS" gene 3470742..3470930 /gene="hmtB" /locus_tag="BSU_37540" /old_locus_tag="BSU37540" /label="hmtB gene" downshifts 3470919 /Source="Nicolas_upshifts" /id="D1945" /incds=0 /nref=72 /ntot=213 /MaxReadThrough="1.74275" /MaxDrop="4.93207" /score="4.21502693" /energy="-10.5" /TU="NA" /idTUdmin="U2950" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3470973..3471392) /gene="ywhA" /locus_tag="BSU_37550" /old_locus_tag="BSU37550" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)" /protein_id="NP_391635.1" /db_xref="EnsemblGenomes-Gn:BSU37550" /db_xref="EnsemblGenomes-Tr:CAB15782" /db_xref="GOA:P70993" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12455" /db_xref="UniProtKB/Swiss-Prot:P70993" /translation="MDHDKLEANLLDHALTKYLKSTKQLDEATVPKHVNNVRGFILRI IYRHGSCTIKDILKEVTLSPSATTTALNHLEQEGFIERSRNNNDRRTVWITLSESGRG AAEQMIENRQQLIDGMFERLTAEEKKTFLAIIAKLAQ*" /label="ywhA CDS" gene complement(3470973..3471392) /gene="ywhA" /locus_tag="BSU_37550" /old_locus_tag="BSU37550" /label="ywhA gene" promotor_-10 complement(3471442..3471461) /Source="Nicolas_upshift_promotors" /id="U2952" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.635364635364635" /psig="0.999000999001" /xcortree=1951 /SigmaFactorBS="aggataaaagctgtgaattcacattttgctTTTTTGACtttc cctattcggaATCAGTAAAATAATAAGTAAatcatatcgttcgtatgttatgaatgca t" /listShort="ywhA, S1454, ywhC, ywhD, S1453" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3471453) /Source="Nicolas_upshifts" /id="U2952" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.635364635364635" /psig="0.999000999001" /xcortree=1951 /SigmaFactorBS="aggataaaagctgtgaattcacattttgctTTTTTGACtttc cctattcggaATCAGTAAAATAATAAGTAAatcatatcgttcgtatgttatgaatgca t" /listShort="ywhA, S1454, ywhC, ywhD, S1453" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3471476..3471483) /Source="Nicolas_upshift_promotors" /id="U2952" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.635364635364635" /psig="0.999000999001" /xcortree=1951 /SigmaFactorBS="aggataaaagctgtgaattcacattttgctTTTTTGACtttc cctattcggaATCAGTAAAATAATAAGTAAatcatatcgttcgtatgttatgaatgca t" /listShort="ywhA, S1454, ywhC, ywhD, S1453" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3471512..3473428) /gene="thrZ" /locus_tag="BSU_37560" /old_locus_tag="BSU37560" /EC_number="6.1.1.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1379177, 8288542, 9353933, 15831787" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1379177, 8288542, 9353933, 15831787; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="threonyl-tRNA synthetase" /protein_id="NP_391636.2" /db_xref="EnsemblGenomes-Gn:BSU37560" /db_xref="EnsemblGenomes-Tr:CAB15783" /db_xref="GOA:P18256" /db_xref="InterPro:IPR002314" /db_xref="InterPro:IPR002320" /db_xref="InterPro:IPR004095" /db_xref="InterPro:IPR004154" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR012676" /db_xref="InterPro:IPR012947" /db_xref="InterPro:IPR018163" /db_xref="InterPro:IPR033728" /db_xref="InterPro:IPR036621" /db_xref="SubtiList:BG10421" /db_xref="UniProtKB/Swiss-Prot:P18256" /translation="MSKHVHIQLPDGQIQEYPKGITIKEAAGSISSSLQKKAAAGQVN GKLVDLSFKLEEDAELSIVTLDSQEGLQVLRHTTAHVLAQAVKRLYGEVSLGVGPVIL DGFYYDMKLGKSLASGDLEAIEKEMKNIINENLEIKRIEVSYEEAEELFAQKDERLKL EILKDIPRGEDITLYQQGEFVDLCRGPHLPSTGMIKAFKLTRVSGAYWRGDSKNEVLQ RVYGVAFQKKKDLDAHLHMLEEAAKRDHRKLGKQLGLFMFSEEAPGMPFYLPKGQIVR NELERFSRELQTNAGYDEVRTPFMMNQRLWEQSGHWDHYRDNMYFSEVDDTRFAMKPM NCPGHMLIFKNSLYSYRDLPIRMAEFGQVHRHEYSGALNGMLRVRTFCQDDAHIFVRE DQIESEIKEAIRLIDEVYRTFGFEYSVELSTRPEDSLGDDSLWEASERALARVLEELG LSYEINEGDGAFYGPKIDFHIKDALKRSHQCATIQLDFQMPEKFDLTYINELNEKVRP VVIHRAVFGSIDRFFGILIEHYGGAFPVWLAPIQVQIIPVSHVHLDYCRKVQAELKQA GIRAGIDERNEKLGYKIRESQVQKIPYVLVLGDHEEQENAVNVRRFGHQQNEHVPFQT FKDKLVKQVENRGM*" /label="thrZ CDS" gene complement(3471512..3473428) /gene="thrZ" /locus_tag="BSU_37560" /old_locus_tag="BSU37560" /label="thrZ gene" promotor_-10 complement(3472706..3472724) /Source="Nicolas_upshift_promotors" /id="U2953" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.713286713286713" /psig="0.713286713286713" /xcortree=1064 /SigmaFactorBS="gtgtacggggttgcgtttcaaaagaaAAAAGatttggatgcg cacctGCATATGCTAGAAGAAGCGgcaaaacgagaccatcgcaagctcggcaaacagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3472711) /Source="Nicolas_upshifts" /id="U2953" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.713286713286713" /psig="0.713286713286713" /xcortree=1064 /SigmaFactorBS="gtgtacggggttgcgtttcaaaagaaAAAAGatttggatgcg cacctGCATATGCTAGAAGAAGCGgcaaaacgagaccatcgcaagctcggcaaacagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3472741..3472745) /Source="Nicolas_upshift_promotors" /id="U2953" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.713286713286713" /psig="0.713286713286713" /xcortree=1064 /SigmaFactorBS="gtgtacggggttgcgtttcaaaagaaAAAAGatttggatgcg cacctGCATATGCTAGAAGAAGCGgcaaaacgagaccatcgcaagctcggcaaacagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3473459) /Source="Nicolas_upshifts" /id="D1946" /incds=0 /nref=1 /ntot=27 /MaxReadThrough="4.2774" /MaxDrop="3.56231" /score="36.3785359" /energy="-19.5" /TU="U2955" /idTUdmin="U2953" /TUdmin="-968" /isTUend="FALSE" /label="downshifts" misc_RNA complement(3473482..3473703) /gene="tboTB" /locus_tag="BSU_misc_RNA_57" /product="T-box" /experiment="publication(s) with functional evidences, PMID:1379177, 8288542, 9098041, 9826762, 12165569, 12547201, 1317842, 15831787" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1379177, 8288542, 9098041, 9826762, 12165569, 12547201, 1317842, 15831787; Product type n: RNA" /function="16.3: Control" /label="tboTB RNA" gene complement(3473482..3473703) /gene="tboTB" /locus_tag="BSU_misc_RNA_57" /label="tboTB gene" misc_RNA complement(3473735..3473956) /gene="tboTA" /locus_tag="BSU_misc_RNA_58" /product="T-box riboswitch specific of threonine tRNA ligase" /experiment="publication(s) with functional evidences, PMID:1379177, 8288542, 9098041, 9826762, 12165569, 12547201, 1317842, 15831787" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1379177, 8288542, 9098041, 9826762, 12165569, 12547201, 1317842, 15831787; Product type n: RNA" /function="16.3: Control" /label="tboTA RNA" gene complement(3473735..3473956) /gene="tboTA" /locus_tag="BSU_misc_RNA_58" /label="tboTA gene" S_feature complement(3473988..3474250) /Source="Nicolas_S_feature" /locus_tag="new_3856732_3856994_c" /HighExp="S8, S7, S6, S5, BT, Sw, B36, B60, T5.0H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.61719100000000005" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S1455" downshifts 3473999 /Source="Nicolas_upshifts" /id="D1947" /incds=0 /nref=1 /ntot=17 /MaxReadThrough="0.92811" /MaxDrop="3.85666" /score="1.17237511" /energy="-8.3" /TU="NA" /idTUdmin="U2950" /TUdmin=3080 /isTUend="FALSE" /label="downshifts" downshifts complement(3474031) /Source="Nicolas_upshifts" /id="D1948" /incds=0 /nref=52 /ntot=200 /MaxReadThrough="6.68945" /MaxDrop="6.6969" /score="36.414771" /energy="-17.3" /TU="U2955" /idTUdmin="U2953" /TUdmin="-1540" /isTUend="FALSE" /label="downshifts" CDS complement(3474038..3474193) /locus_tag="BSU_37569" /old_locus_tag="BSU37569" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514011.1" /translation="MLFTVSREGRTAEIFLTQGKQLTAFEPYQGKQVSDTVMLRYSIF KPIIMCN*" /label="hypothetical protein CDS" gene complement(3474038..3474193) /locus_tag="BSU_37569" /old_locus_tag="BSU37569" /label="gene" promotor_-35 3474200..3474203 /Source="Nicolas_upshift_promotors" /id="U2954" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.717282717282717" /psig="0.094905094905095" /xcortree=712 /SigmaFactorBS="gctgtccttccctctctggaaaccgtaaaaagcatctcgtgT CCTtatcagtgCCTGTTGTTTCAATaattttttatatcttactatatattcccacaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3474212..3474225 /Source="Nicolas_upshift_promotors" /id="U2954" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.717282717282717" /psig="0.094905094905095" /xcortree=712 /SigmaFactorBS="gctgtccttccctctctggaaaccgtaaaaagcatctcgtgT CCTtatcagtgCCTGTTGTTTCAATaattttttatatcttactatatattcccacaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3474219 /Source="Nicolas_upshifts" /id="U2954" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.717282717282717" /psig="0.094905094905095" /xcortree=712 /SigmaFactorBS="gctgtccttccctctctggaaaccgtaaaaagcatctcgtgT CCTtatcagtgCCTGTTGTTTCAATaattttttatatcttactatatattcccacaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3474227..3474246) /Source="Nicolas_upshift_promotors" /id="U2955" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.457542457542458" /psig="0.995004995004995" /xcortree=601 /SigmaFactorBS="ctgcccataacgggactgccgcgtcagaaaaaatgtaaatca ctGATTGCGctttgtgggaataTATAGTAAGATATAAAAAATtattgaaacaacaggc a" /listShort="S1455, NA, NA, thrZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3474250) /Source="Nicolas_upshifts" /id="U2955" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.457542457542458" /psig="0.995004995004995" /xcortree=601 /SigmaFactorBS="ctgcccataacgggactgccgcgtcagaaaaaatgtaaatca ctGATTGCGctttgtgggaataTATAGTAAGATATAAAAAATtattgaaacaacaggc a" /listShort="S1455, NA, NA, thrZ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3474260..3474266) /Source="Nicolas_upshift_promotors" /id="U2955" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.457542457542458" /psig="0.995004995004995" /xcortree=601 /SigmaFactorBS="ctgcccataacgggactgccgcgtcagaaaaaatgtaaatca ctGATTGCGctttgtgggaataTATAGTAAGATATAAAAAATtattgaaacaacaggc a" /listShort="S1455, NA, NA, thrZ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3474273..3475673) /gene="mmr" /locus_tag="BSU_37570" /old_locus_tag="BSU37570" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11104814, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11104814, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="toxic compound efflux transporter (may export homoserine)" /protein_id="NP_391637.1" /db_xref="EnsemblGenomes-Gn:BSU37570" /db_xref="EnsemblGenomes-Tr:CAB15784" /db_xref="GOA:Q00538" /db_xref="InterPro:IPR004638" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10420" /db_xref="UniProtKB/Swiss-Prot:Q00538" /translation="MKNSGSIQESTSSTGISVLIVLALGFLMATLDVTVVNVAMADMK NTLSMSLSGVTWVVDGYILTFASLLLAGGALADRFGSKTIYILGLAVFVMASCLCAAS INGQMLIAGRLIQGIGAALFMPSSLSLLAASYLDERARARMFGLWAALVSAASALGPF IGGVLVQLAGWQSIFLINVPIGAAALISAYRILSRVPGKSSRVNIIGHLLGMMALGFL SYALIQGPSAGWRSPVILVAFTAAVLAFVLFLLREISAKTPILPASLYKNGRFSAAQF IGFLLNFALFGGMFMLSLFLQEAGGASSFMAGVELLPMMAVFVIGNLLFARLANRFEA GQLMFVSMAVSCIIALLLFVLISPDFPYWQLAVLMSVMNLCTGITVPAMTTVIMQAAG QRHTNIAGAALNANRQIGALVGVAITGVIIHLSATWYAGAGFAFLMMGAAYSLAALLV WLFLAAHNGTAASEKM*" /label="mmr CDS" gene complement(3474273..3475673) /gene="mmr" /locus_tag="BSU_37570" /old_locus_tag="BSU37570" /label="mmr gene" CDS complement(3475673..3476143) /gene="ywgB" /locus_tag="BSU_37580" /old_locus_tag="BSU37580" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16885456; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_391638.1" /db_xref="EnsemblGenomes-Gn:BSU37580" /db_xref="EnsemblGenomes-Tr:CAB15785" /db_xref="GOA:P71047" /db_xref="InterPro:IPR000944" /db_xref="InterPro:IPR030489" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12454" /db_xref="UniProtKB/Swiss-Prot:P71047" /translation="MKMKSGMEQAVSVLLLLSRLPVQASLTSEAISQRLRVSPSYLKK LMRTLVQAGLAESLPGTKGGFTLTKPLADITLYDVYQAVEGRGSMYQGKGLLQSVFEG ESHCVLETVMAEIEDKWSNLMREESLQHVMDRVGELYDLEKIDDWVIKQVKGQL*" /label="ywgB CDS" gene complement(3475673..3476143) /gene="ywgB" /locus_tag="BSU_37580" /old_locus_tag="BSU37580" /label="ywgB gene" downshifts complement(3476099) /Source="Nicolas_upshifts" /id="D1949" /incds=0 /nref=11 /ntot=145 /MaxReadThrough="2.78131" /MaxDrop="4.29115" /score="17.3758052" /energy="-11.2" /TU="NA" /idTUdmin="U2956" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3476255..3476755) /gene="ywgA" /locus_tag="BSU_37590" /old_locus_tag="BSU37590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16855250" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391639.1" /db_xref="EnsemblGenomes-Gn:BSU37590" /db_xref="EnsemblGenomes-Tr:CAB15786" /db_xref="SubtiList:BG12453" /db_xref="UniProtKB/Swiss-Prot:P71046" /translation="MLKEHAKLMKVFSDSGEIIGRKKLQKMIYIAKKMQFPFYEKYDF HFYGPYSEELTLQIEELCNLGFLHEVKEKKGGYFQYRYSLTETGSAFLDHADLDMPDM KGYIDSVNSRSSRFLELVSTILYFDGLEDEEKKEKVFTIKSKQKYTNEEYDEALQYIE ELKQIC*" /label="ywgA CDS" gene complement(3476255..3476755) /gene="ywgA" /locus_tag="BSU_37590" /old_locus_tag="BSU37590" /label="ywgA gene" downshifts complement(3476258) /Source="Nicolas_upshifts" /id="D1950" /incds=0 /nref=9 /ntot=105 /MaxReadThrough="4.00805" /MaxDrop="6.12059" /score="17.3758052" /energy="-11.2" /TU="U2956,U2957" /idTUdmin="U2957" /TUdmin="-137" /isTUend="FALSE" /label="downshifts" CDS complement(3476791..3478092) /gene="ywfO" /locus_tag="BSU_37600" /old_locus_tag="BSU37600" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16855250; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent nucleotide (pyro)phosphohydrolase" /protein_id="NP_391640.1" /db_xref="EnsemblGenomes-Gn:BSU37600" /db_xref="EnsemblGenomes-Tr:CAB15787" /db_xref="GOA:P39651" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR006674" /db_xref="SubtiList:BG10639" /db_xref="UniProtKB/Swiss-Prot:P39651" /translation="MAYPNGKLSEEKVFKDPVHRYVHVRDKLIWDLIGTREFQRLRRI KQLGTTYLTFHGAEHSRFNHSLGVYEIVRRMVDDVFKGRPEWDDSERELCLAAALLHD LGHGPFSHSFEKVFHLDHEDFTRGIILGDTEVNQVLRKVSPGFPQDVAEVIAKTYKNK QVVSLISSQIDADRMDYLQRDAYYTGVSYGHFDMERILRVMRPREDQIVIKESGMHAV EDYIMSRYQMYWQVYFHPVTRSAEVILTKILHRAKQLHDEGYVFTHAPVHFYSIFEGK LTLEDYVKLDESIILYYFQAWEDEEDAILSDLCRRFINRQLFQYVEFNPNEEMSAYFE LTSLFKEAGIDPSYYLVVDSSSDLPYDFYRPGEEEERLPIHLLTQNGQIKELSRQSAI VESISGKRRTDHKLYYPKDLICDGTKHPEAKMKIRQLLGLT*" /label="ywfO CDS" gene complement(3476791..3478092) /gene="ywfO" /locus_tag="BSU_37600" /old_locus_tag="BSU37600" /label="ywfO gene" promotor_-10 complement(3478116..3478135) /Source="Nicolas_upshift_promotors" /id="U2956" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig="0.992007992007992" /xcortree=2244 /SigmaFactorBS="tcatgaagatggaacaaatcgccgggcaaattcaaggATGtt ttcaaagaatagaGTCGATATAATAGAAACACGgctaaaaaaaagagggaatgacgat g" /listShort="ywfO, ywgA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3478130) /Source="Nicolas_upshifts" /id="U2956" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig="0.992007992007992" /xcortree=2244 /SigmaFactorBS="tcatgaagatggaacaaatcgccgggcaaattcaaggATGtt ttcaaagaatagaGTCGATATAATAGAAACACGgctaaaaaaaagagggaatgacgat g" /listShort="ywfO, ywgA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3478132..3478253) /Source="Nicolas_S_feature" /locus_tag="new_3860876_3860997_c" /HighExp="G180, Paraq, Oxctl, G135, H2O2, G150, C30, LBGstat, LBGexp, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1456" promotor_-35 complement(3478151..3478153) /Source="Nicolas_upshift_promotors" /id="U2956" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig="0.992007992007992" /xcortree=2244 /SigmaFactorBS="tcatgaagatggaacaaatcgccgggcaaattcaaggATGtt ttcaaagaatagaGTCGATATAATAGAAACACGgctaaaaaaaagagggaatgacgat g" /listShort="ywfO, ywgA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3478254..3478478) /gene="ywzC" /locus_tag="BSU_37610" /old_locus_tag="BSU37610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16855250" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391641.1" /db_xref="EnsemblGenomes-Gn:BSU37610" /db_xref="EnsemblGenomes-Tr:CAB15788" /db_xref="InterPro:IPR009910" /db_xref="InterPro:IPR020880" /db_xref="SubtiList:BG14164" /db_xref="UniProtKB/Swiss-Prot:O32280" /translation="MANEFRVCDDCQATNIKTLLPRLKEVDPDAKVEVGCQSYCGPGR KKSFAFVNNRPLSAPTEDELIDKVKKKIKK*" /label="ywzC CDS" gene complement(3478254..3478478) /gene="ywzC" /locus_tag="BSU_37610" /old_locus_tag="BSU37610" /label="ywzC gene" S_feature complement(3478479..3478563) /Source="Nicolas_S_feature" /locus_tag="new_3861223_3861307_c" /HighExp="G180, Paraq, H2O2, G135, LBGexp, dia15, G150, Lbexp, Heat, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1457" promotor_-10 complement(3478552..3478571) /Source="Nicolas_upshift_promotors" /id="U2957" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.543456543456543" /psig=1 /xcortree=2595 /SigmaFactorBS="ctgaaagaataggagatacgaaggatggagcggCTTGcagga acagtcgaaTCCTTGTAAAATGAAGTGTGatgtgattttttttgaaacgtgattttag g" /listShort="S1457, ywzC, S1456, ywfO, ywgA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3478562) /Source="Nicolas_upshifts" /id="U2957" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.543456543456543" /psig=1 /xcortree=2595 /SigmaFactorBS="ctgaaagaataggagatacgaaggatggagcggCTTGcagga acagtcgaaTCCTTGTAAAATGAAGTGTGatgtgattttttttgaaacgtgattttag g" /listShort="S1457, ywzC, S1456, ywfO, ywgA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3478586..3478589) /Source="Nicolas_upshift_promotors" /id="U2957" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.543456543456543" /psig=1 /xcortree=2595 /SigmaFactorBS="ctgaaagaataggagatacgaaggatggagcggCTTGcagga acagtcgaaTCCTTGTAAAATGAAGTGTGatgtgattttttttgaaacgtgattttag g" /listShort="S1457, ywzC, S1456, ywfO, ywgA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3478629..3478635 /Source="Nicolas_upshift_promotors" /id="U2958" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.836163836163836" /psig="0.836163836163836" /xcortree=1045 /SigmaFactorBS="cgctccatccttcgtatctcctattctttcagccaattTGTA TAAatattttccaacctGGACATTCTAATaccatgaaaagaaaaatgggagttgagat a" /listShort="rsfA, S1458" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3478650..3478661 /Source="Nicolas_upshift_promotors" /id="U2958" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.836163836163836" /psig="0.836163836163836" /xcortree=1045 /SigmaFactorBS="cgctccatccttcgtatctcctattctttcagccaattTGTA TAAatattttccaacctGGACATTCTAATaccatgaaaagaaaaatgggagttgagat a" /listShort="rsfA, S1458" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3478651 /Source="Nicolas_upshifts" /id="U2958" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.836163836163836" /psig="0.836163836163836" /xcortree=1045 /SigmaFactorBS="cgctccatccttcgtatctcctattctttcagccaattTGTA TAAatattttccaacctGGACATTCTAATaccatgaaaagaaaaatgggagttgagat a" /listShort="rsfA, S1458" /GFF_Attribute="listLong" /label="upshifts" CDS 3478693..3479469 /gene="psrF" /locus_tag="BSU_37620" /old_locus_tag="BSU37620" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10629188, 16497325, 22829778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10629188, 16497325, 22829778; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="prespore-specific transcription regulatory gene" /protein_id="NP_391642.1" /db_xref="EnsemblGenomes-Gn:BSU37620" /db_xref="EnsemblGenomes-Tr:CAB15789" /db_xref="GOA:P39650" /db_xref="InterPro:IPR014243" /db_xref="InterPro:IPR017877" /db_xref="SubtiList:BG10638" /db_xref="UniProtKB/Swiss-Prot:P39650" /translation="MTKQRQDAWSEENDLLLAETVLRHVREGSTQLNAFEEVGDKLNR TSAACGFRWNAVVRHQYEKALQLAKKQRKQRMRALGNGQPAKKRLLYQPPAVDPEIIQ ETAAEEPVKTETPSVENEQPLMSGEHMPFVDESFKEELASLSHLLSPQTPAAAPEMTM NDVIRFLQNYEGNHEQSSALKMENERLKKENQELQNKTEQLEAEVQKLEKDQKTIQED YETLVKIMNRARKLVLFEEDEHASPSFKMDRNGNLEKLAE*" /label="psrF CDS" gene 3478693..3479469 /gene="psrF" /locus_tag="BSU_37620" /old_locus_tag="BSU37620" /label="psrF gene" downshifts 3479455 /Source="Nicolas_upshifts" /id="D1951" /incds=0 /nref=14 /ntot=78 /MaxReadThrough="4.08166" /MaxDrop="4.36214" /score="-5.88286948" /energy="-14.4" /TU="U2958" /idTUdmin="U2958" /TUdmin="-3036" /isTUend="FALSE" /label="downshifts" promotor_-35 3479557..3479564 /Source="Nicolas_upshift_promotors" /id="U2959" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig=1 /xcortree=2969 /SigmaFactorBS="atccccttttctattgagaaaagagaatttcctcATTTTGCA gccggatcagctatTCTTGTAAAATGAGGCCAAGcttatgtgaatctattaagacatg t" /listShort="S1458, ywfI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3479579..3479598 /Source="Nicolas_upshift_promotors" /id="U2959" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig=1 /xcortree=2969 /SigmaFactorBS="atccccttttctattgagaaaagagaatttcctcATTTTGCA gccggatcagctatTCTTGTAAAATGAGGCCAAGcttatgtgaatctattaagacatg t" /listShort="S1458, ywfI" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3479583..3483809 /Source="Nicolas_S_feature" /locus_tag="new_3862327_3866553" /HighExp="T1.30H, T2.0H, T1.0H, T2.30H, T0.30H, T3.0H, T3.30H, T4.0H, T5.0H, T0.0H" /AntisenseName="pta" /AntisenseCor="-0.61235087907102503" /AntisenseRegPval="-28.3" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF" /TUshortPSig="1, 0.836" /TUlongSig="NA" /TUlongPSig="NA" /label="S1458" upshifts 3479583 /Source="Nicolas_upshifts" /id="U2959" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig=1 /xcortree=2969 /SigmaFactorBS="atccccttttctattgagaaaagagaatttcctcATTTTGCA gccggatcagctatTCTTGTAAAATGAGGCCAAGcttatgtgaatctattaagacatg t" /listShort="S1458, ywfI" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3479613..3480503) /gene="ywfM" /locus_tag="BSU_37630" /old_locus_tag="BSU37630" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative toxic excess metabolite exporter" /protein_id="NP_391643.1" /db_xref="EnsemblGenomes-Gn:BSU37630" /db_xref="EnsemblGenomes-Tr:CAB15790" /db_xref="GOA:P39649" /db_xref="InterPro:IPR000620" /db_xref="InterPro:IPR004779" /db_xref="SubtiList:BG10637" /db_xref="UniProtKB/Swiss-Prot:P39649" /translation="MKGNIYSLFVLIAAFFWGTTGTVQALAPESATPLAFGAFRLLIG GSAMLLAVWISRELHVKNWAWPLVFLAAVCMACYQPLFFTAVKETGIAVGTVIAIGSA PIIAGTLEWAVLKKRPRNSWWIATVLALAGCWLLFSDSSNVRIDVAGVLMALGAGASF AGYTLISKAMMKTQPPRATSAVVFMISAILLTPLLWQLDISWILTPRGLGTSLYIGLI ATCAAYFLFAKGLTGVPASAAVTLSLAEPLTASLLGVFFIGEMLSPSSWLGIALMMLG LLVISAAPRKQKTAEAAHMS*" /label="ywfM CDS" gene complement(3479613..3480503) /gene="ywfM" /locus_tag="BSU_37630" /old_locus_tag="BSU37630" /label="ywfM gene" promotor_no_box complement(3480503..3480603) /Source="Nicolas_upshift_promotors" /id="U2960" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.568431568431568" /psig="0.136863136863137" /xcortree=1729 /SigmaFactorBS="taatcttattttcagataagtccttcttacatacagataacc acgacaaaaagaaaaacgataaaatgacatcagcatccatattaaaggggagaggcag a" /listShort="ywfM" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(3480543) /Source="Nicolas_upshifts" /id="U2960" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.568431568431568" /psig="0.136863136863137" /xcortree=1729 /SigmaFactorBS="taatcttattttcagataagtccttcttacatacagataacc acgacaaaaagaaaaacgataaaatgacatcagcatccatattaaaggggagaggcag a" /listShort="ywfM" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3480671..3481516) /gene="lipL" /locus_tag="BSU_37640" /old_locus_tag="BSU37640" /function="4: Biosynthesis of cofactors, prosthetic groups, and carriers" /experiment="publication(s) with functional evidences, PMID:21338420, 21338421" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21338420, 21338421; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="amidotransferase of the octanoyl moiety from octanoyl-GcvH to the E2 subunit of pyruvate dehydrogenase" /protein_id="NP_391644.1" /db_xref="EnsemblGenomes-Gn:BSU37640" /db_xref="EnsemblGenomes-Tr:CAB15791" /db_xref="GOA:P39648" /db_xref="InterPro:IPR004143" /db_xref="InterPro:IPR024897" /db_xref="SubtiList:BG10636" /db_xref="UniProtKB/Swiss-Prot:P39648" /translation="MANQPIDLLMQPKWRVIDQSSLGPLFDAKQSFAMDDTLCMSVGK GVSPATARSWVHHDTIVLGIQDTRLPFLQDGISLLESEGYRVIVRNSGGLAVVLDDGV LNISLIFEDEKKGIDIDKGYEAMVELMRRMLRPYNAKIEAYEIEGSYCPGSYDLSING KKFAGISQRRVRGGVAVQIYLCADKSGSERADLIRRFYQAALKDKQNDKKGVYPEIRP ETMASLSELLQKDISVQDLMFALLTELKALSTHLYSAGLSIDEEMEFEKNLVRMAERN AKVFG*" /label="lipL CDS" gene complement(3480671..3481516) /gene="lipL" /locus_tag="BSU_37640" /old_locus_tag="BSU37640" /label="lipL gene" downshifts complement(3480834) /Source="Nicolas_upshifts" /id="D1952" /incds=1 /nref=4 /ntot=180 /MaxReadThrough="3.21908" /MaxDrop="3.30122" /score="31.9003746" /energy="-18.6" /TU="U2961" /idTUdmin="U2961" /TUdmin="-27" /isTUend="FALSE" /label="downshifts" CDS complement(3481565..3482464) /gene="cysL" /locus_tag="BSU_37650" /old_locus_tag="BSU37650" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12169591" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12169591; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of sulfur assimilation CysL, activatescysJI expression" /protein_id="NP_391645.1" /db_xref="EnsemblGenomes-Gn:BSU37650" /db_xref="EnsemblGenomes-Tr:CAB15792" /db_xref="GOA:P39647" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10635" /db_xref="UniProtKB/Swiss-Prot:P39647" /translation="MYYDVLKTFIAVVEEKNFTKAAEKLMISQPSVSLHIKNLEKEFQ TALLNRSPKHFTTTPTGDILYQRAKQMVFLYEQAKAEIYAHHHYVKGELKIAASFTIG EYILPPLLAQLQKLYPELNLDVMIGNTEEVSERVRMLQADIGLIEGHTNENELEIEPF MEDEMCIAAPNQHPLAGRKEISISDLQNEAWVTREKGSGTREYLDHVLSSNGLRPKSM FTISSNQGVKEAVINGMGLSVLSRSVLRKDLIHREISILHINNFSLKRKLSYIHSPLM ENTKNKEIFITMLKSNYQSQLLK*" /label="cysL CDS" gene complement(3481565..3482464) /gene="cysL" /locus_tag="BSU_37650" /old_locus_tag="BSU37650" /label="cysL gene" promotor_-10 complement(3482507..3482526) /Source="Nicolas_upshift_promotors" /id="U2961" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.643356643356643" /psig="0.988011988011988" /xcortree=1930 /SigmaFactorBS="ttttttgcgcttctgtatagcccTTCTTTACcaagacggatg atATGAGTACAATAAAGAAAACtaatcataaccatatatttcattaatgacaggggtg g" /listShort="cysL, ywfL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3482510) /Source="Nicolas_upshifts" /id="U2961" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.643356643356643" /psig="0.988011988011988" /xcortree=1930 /SigmaFactorBS="ttttttgcgcttctgtatagcccTTCTTTACcaagacggatg atATGAGTACAATAAAGAAAACtaatcataaccatatatttcattaatgacaggggtg g" /listShort="cysL, ywfL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3482540..3482547) /Source="Nicolas_upshift_promotors" /id="U2961" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.643356643356643" /psig="0.988011988011988" /xcortree=1930 /SigmaFactorBS="ttttttgcgcttctgtatagcccTTCTTTACcaagacggatg atATGAGTACAATAAAGAAAACtaatcataaccatatatttcattaatgacaggggtg g" /listShort="cysL, ywfL" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3482611) /Source="Nicolas_upshifts" /id="D1953" /incds=0 /nref=222 /ntot=251 /MaxReadThrough="1.96406" /MaxDrop="7.24606" /score="32.3178773" /energy="-17.3" /TU="NA" /idTUdmin="U2962" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3482611..3483582) /gene="pta" /locus_tag="BSU_37660" /old_locus_tag="BSU37660" /EC_number="2.3.1.8" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:4201530, 10559153, 10809684, 16283428, 17183215, 17233734, 21453533, 23468065, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4201530, 10559153, 10809684, 16283428, 17183215, 17233734, 21453533, 23468065, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphotransacetylase" /protein_id="NP_391646.1" /db_xref="EnsemblGenomes-Gn:BSU37660" /db_xref="EnsemblGenomes-Tr:CAB15793" /db_xref="GOA:P39646" /db_xref="InterPro:IPR002505" /db_xref="InterPro:IPR004614" /db_xref="InterPro:IPR012147" /db_xref="PDB:1TD9" /db_xref="PDB:1XCO" /db_xref="SubtiList:BG10634" /db_xref="UniProtKB/Swiss-Prot:P39646" /translation="MADLFSTVQEKVAGKDVKIVFPEGLDERILEAVSKLAGNKVLNP IVIGNENEIQAKAKELNLTLGGVKIYDPHTYEGMEDLVQAFVERRKGKATEEQARKAL LDENYFGTMLVYKGLADGLVSGAAHSTADTVRPALQIIKTKEGVKKTSGVFIMARGEE QYVFADCAINIAPDSQDLAEIAIESANTAKMFDIEPRVAMLSFSTKGSAKSDETEKVA DAVKIAKEKAPELTLDGEFQFDAAFVPSVAEKKAPDSEIKGDANVFVFPSLEAGNIGY KIAQRLGNFEAVGPILQGLNMPVNDLSRGCNAEDVYNLALITAAQAL*" /label="pta CDS" gene complement(3482611..3483582) /gene="pta" /locus_tag="BSU_37660" /old_locus_tag="BSU37660" /label="pta gene" promotor_-10 complement(3483617..3483636) /Source="Nicolas_upshift_promotors" /id="U2962" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.808191808191808" /psig="0.974025974025974" /xcortree=2697 /SigmaFactorBS="tagaaaaataagatttttttatgaaagcgctataatgaaagt tggcTGTTTgaatttgattggaagAAGAGTATGCTAGTAAAAGAaagcgtttttgtaa c" /listShort="pta" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3483642) /Source="Nicolas_upshifts" /id="U2962" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.808191808191808" /psig="0.974025974025974" /xcortree=2697 /SigmaFactorBS="tagaaaaataagatttttttatgaaagcgctataatgaaagt tggcTGTTTgaatttgattggaagAAGAGTATGCTAGTAAAAGAaagcgtttttgtaa c" /listShort="pta" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3483652..3483656) /Source="Nicolas_upshift_promotors" /id="U2962" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.808191808191808" /psig="0.974025974025974" /xcortree=2697 /SigmaFactorBS="tagaaaaataagatttttttatgaaagcgctataatgaaagt tggcTGTTTgaatttgattggaagAAGAGTATGCTAGTAAAAGAaagcgtttttgtaa c" /listShort="pta" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3483730..3483741) /Source="Nicolas_upshift_promotors" /id="U2963" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=874 /SigmaFactorBS="ttctactgtggagaaaccttgaacatcccttcCGTATAActc catcaaaataGAAGAACCTATAagggaagattgagtcacttaaattagttagaaaaat a" /listShort="pta" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3483733) /Source="Nicolas_upshifts" /id="U2963" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=874 /SigmaFactorBS="ttctactgtggagaaaccttgaacatcccttcCGTATAActc catcaaaataGAAGAACCTATAagggaagattgagtcacttaaattagttagaaaaat a" /listShort="pta" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3483755..3483761) /Source="Nicolas_upshift_promotors" /id="U2963" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=874 /SigmaFactorBS="ttctactgtggagaaaccttgaacatcccttcCGTATAActc catcaaaataGAAGAACCTATAagggaagattgagtcacttaaattagttagaaaaat a" /listShort="pta" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 3483804..3483823 /Source="Nicolas_upshift_promotors" /id="U2964" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.821178821178821" /psig=1 /xcortree=1605 /SigmaFactorBS="ggagttatacggaagggatgttcaaggtttctccacagtaga atcggataaacTATGGTATAGTGAAGGCAATcatgaaaagataatgggagtgaagata a" /listShort="ywfI, ywfH" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3483811 /Source="Nicolas_upshifts" /id="U2964" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.821178821178821" /psig=1 /xcortree=1605 /SigmaFactorBS="ggagttatacggaagggatgttcaaggtttctccacagtaga atcggataaacTATGGTATAGTGAAGGCAATcatgaaaagataatgggagtgaagata a" /listShort="ywfI, ywfH" /GFF_Attribute="listLong" /label="upshifts" CDS 3483852..3484616 /gene="hemQ" /locus_tag="BSU_37670" /old_locus_tag="BSU37670" /EC_number="4.1.-.-" /function="4.3: Heme, porphyrin, and cobalamin" /experiment="publication(s) with functional evidences, PMID:15317589, 16403788, 20543190, 25711532, 26083961, 27599156, 27758026, 27597779, 27936663, 27982566" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15317589, 16403788, 20543190, 25711532, 26083961, 27599156, 27758026, 27597779, 27936663, 27982566; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="iron-coproporphyrin (coproheme) decarboxylase" /protein_id="NP_391647.3" /db_xref="EnsemblGenomes-Gn:BSU37670" /db_xref="EnsemblGenomes-Tr:CAB15794" /db_xref="GOA:P39645" /db_xref="InterPro:IPR010644" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR031332" /db_xref="SubtiList:BG10633" /db_xref="UniProtKB/Swiss-Prot:P39645" /translation="MSEQQMTNEAAKTLDGWYALHDFRTMDWASWKLLSSDERQSIIH EFTGLLEKWGVAQKEGKGSQTLYSIVGQKADFMLMILRPTMEELNQIELEFNKSRLAE FTIPAYSYVSVVELSNYLASGDGDPYENPHVRARLYPELPESKYVCFYPMDKRRSGND NWYMLSMEERRNLMRSHGLIGRSYAGKVKQIITGSVGFDDYEWGVTLFSDDVLQFKKL VYEMRFDEVSARYGEFGSFFVGNHLSLDTLPQFLYV*" /label="hemQ CDS" gene 3483852..3484616 /gene="hemQ" /locus_tag="BSU_37670" /old_locus_tag="BSU37670" /label="hemQ gene" downshifts 3484603 /Source="Nicolas_upshifts" /id="D1954" /incds=0 /nref=155 /ntot=246 /MaxReadThrough="5.49286" /MaxDrop="6.26609" /score="19.319449" /energy="-14.5" /TU="U2964" /idTUdmin="U2959" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 3484679..3484685 /Source="Nicolas_upshift_promotors" /id="U2965" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.383616383616384" /psig="0.999000999001" /xcortree=2901 /SigmaFactorBS="ttcaattctcctttatcagaatttaaataaaATTTGCTattt tcttcgtttTTTCTTACGATGTAGATAATaatccatttttttcaaaggggtgcagtta t" /listShort="ywfH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3484699..3484718 /Source="Nicolas_upshift_promotors" /id="U2965" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.383616383616384" /psig="0.999000999001" /xcortree=2901 /SigmaFactorBS="ttcaattctcctttatcagaatttaaataaaATTTGCTattt tcttcgtttTTTCTTACGATGTAGATAATaatccatttttttcaaaggggtgcagtta t" /listShort="ywfH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3484708 /Source="Nicolas_upshifts" /id="U2965" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.383616383616384" /psig="0.999000999001" /xcortree=2901 /SigmaFactorBS="ttcaattctcctttatcagaatttaaataaaATTTGCTattt tcttcgtttTTTCTTACGATGTAGATAATaatccatttttttcaaaggggtgcagtta t" /listShort="ywfH" /GFF_Attribute="listLong" /label="upshifts" CDS 3484749..3485528 /gene="bacG" /locus_tag="BSU_37680" /old_locus_tag="BSU37680" /EC_number="1.3.1.-" /function="16.8: Protect" /function="16.4: Excrete" /experiment="publication(s) with functional evidences, PMID:12372825, 20052993, 23519407, 25644640" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12372825, 20052993, 23519407, 25644640; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cyclohexenol-containing tetrahydro-4-hydroxyphenylpyruvate H(4)HPP in bacilysin synthesis" /protein_id="NP_391648.1" /db_xref="EnsemblGenomes-Gn:BSU37680" /db_xref="EnsemblGenomes-Tr:CAB15795" /db_xref="GOA:P39644" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="PDB:3U49" /db_xref="PDB:3U4C" /db_xref="PDB:3U4D" /db_xref="SubtiList:BG10632" /db_xref="UniProtKB/Swiss-Prot:P39644" /translation="MSKRTAFVMGASQGIGKAIALKLADQHFSLVINSRNLDNIESVK EDILAKHPEASVIVLAGDMSDQHTRAGIFQKIESQCGRLDVLINNIPGGAPDTFDNCN IEDMTATFTQKTVAYIDAIKRASSLMKQNEFGRIINIVGNLWKEPGANMFTNSMMNAA LINASKNISIQLAPHNITVNCLNPGFIATDRYHQFVENVMKKNSISKQKAEEQIASGI PMKRVGSAEETAALAAFLASEEASYITGQQISADGGSMKSI*" /label="bacG CDS" gene 3484749..3485528 /gene="bacG" /locus_tag="BSU_37680" /old_locus_tag="BSU37680" /label="bacG gene" downshifts 3485505 /Source="Nicolas_upshifts" /id="D1955" /incds=0 /nref=84 /ntot=226 /MaxReadThrough="3.12719" /MaxDrop="4.87473" /score="3.07615905" /energy="-11.9" /TU="U2965" /idTUdmin="U2964" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3485543..3486742) /gene="bacF" /locus_tag="BSU_37690" /old_locus_tag="BSU37690" /function="16.4: Excrete" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12372825, 12670965, 15609023, 20052993, 18957859, 19061923, 25261512, 25472439, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12372825, 12670965, 15609023, 20052993, 18957859, 19061923, 25261512, 25472439, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phenylalanine aminotransferase forming tetrahydrotyrosine in bacilysin synthesis" /protein_id="NP_391649.1" /db_xref="EnsemblGenomes-Gn:BSU37690" /db_xref="EnsemblGenomes-Tr:CAB15796" /db_xref="GOA:P39643" /db_xref="InterPro:IPR004838" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG10631" /db_xref="UniProtKB/Swiss-Prot:P39643" /translation="MEITPSDVIKTLPRQEFSLVFQKVKEMEKTGAHIINLGQGNPDL PTPPHIVEALREASLNPSFHGYGPFRGYPFLKEAIAAFYKREYGVTINPETEVALFGG GKAGLYVLTQCLLNPGDIALVPNPGYPEYLSGITMARAELYEMPLYEENGYLPDFEKI DPAVLEKAKLMFLNYPNNPTGAVADAAFYAKAAAFAKEHNIHLIHDFAYGAFEFDQKP ASFLEAEDAKTVGAELYSFSKTFNMAGWRMAFAVGNEKIIQAVNEFQDHVFVGMFGGL QQAASAALSGDPEHTESLKRIYKERIDFFTALCEKELGWKMEKPKGTFYVWAEIPNTF ETSHQFSDYLLEHAHVVVTPGEIFGSNGKRHVRISMVSKQEDLREFVTRIQKLNLPFG SLQETSR*" /label="bacF CDS" gene complement(3485543..3486742) /gene="bacF" /locus_tag="BSU_37690" /old_locus_tag="BSU37690" /label="bacF gene" CDS complement(3486743..3487927) /gene="bacE" /locus_tag="BSU_37700" /old_locus_tag="BSU37700" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12372825, 15609023, 15849754, 16850406, 18957859, 19061923, 25261512, 25472439, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12372825, 15609023, 15849754, 16850406, 18957859, 19061923, 25261512, 25472439, 26284661; Product type t: transporter" /codon_start=1 /transl_table=11 /product="efflux protein for bacilysin excretion, self-protection against bacilysin" /protein_id="NP_391650.1" /db_xref="EnsemblGenomes-Gn:BSU37700" /db_xref="EnsemblGenomes-Tr:CAB15797" /db_xref="GOA:P39642" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR022324" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10630" /db_xref="UniProtKB/Swiss-Prot:P39642" /translation="MKQLKPNSKYLLYGQALSFMGDYCVLPALLILSTYYHDYWVTSG VIVVRSIPMVFQPFLGVLVDRLDRIKIMLWTDIIRGIIFLGLTFLPKGEYPLIFLALL FITYGSGVFFNPARLAVMSSLESDIKSINTLFAKATTISIIVGAAAGGLFLLGGSVEL AVAFNGVTYLVSAFFISRIKLQFVPIQSENIKEAFQSFKEGLKEIKTNSFVLNAMFTM ITMALLWGVVYSYFPIVSRFLGDGEIGNFILTFCIGFGGFIGAALVSKWGFNNNRGLT YFTVLSIVSLALFLFTPIFAVSVIAAILFFIAMEYGEVLAKVKVQENAANQIQGRIFS VAEASIGLCISIGSMFINILSAPVIMGLIVVIVCGLFLHTKLVNKSFLERDNKTEQKG VF*" /label="bacE CDS" gene complement(3486743..3487927) /gene="bacE" /locus_tag="BSU_37700" /old_locus_tag="BSU37700" /label="bacE gene" CDS complement(3487924..3489342) /gene="bacD" /locus_tag="BSU_37710" /old_locus_tag="BSU37710" /EC_number="6.3.2.49" /function="16.8: Protect" /function="16.4: Excrete" /experiment="publication(s) with functional evidences, PMID:15609023, 16030213, 18957859, 19061923, 22298000, 22407814, 24702628, 25261512, 25472439, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15609023, 16030213, 18957859, 19061923, 22298000, 22407814, 24702628, 25261512, 25472439, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alanine-anticapsin ligase" /protein_id="NP_391651.1" /db_xref="EnsemblGenomes-Gn:BSU37710" /db_xref="EnsemblGenomes-Tr:CAB15798" /db_xref="GOA:P39641" /db_xref="InterPro:IPR011761" /db_xref="PDB:3VMM" /db_xref="PDB:3WNZ" /db_xref="PDB:3WO0" /db_xref="PDB:3WO1" /db_xref="SubtiList:BG10629" /db_xref="UniProtKB/Swiss-Prot:P39641" /translation="MERKTVLVIADLGGCPPHMFYKSAAEKYNLVSFIPRPFAITASH AALIEKYSVAVIKDKDYFKSLADFEHPDSIYWAHEDHNKPEEEVVEQIVKVAEMFGAD AITTNNELFIAPMAKACERLGLRGAGVQAAENARDKNKMRDAFNKAGVKSIKNKRVTT LEDFRAALEEIGTPLILKPTYLASSIGVTLITDTETAEDEFNRVNDYLKSINVPKAVT FEAPFIAEEFLQGEYGDWYQTEGYSDYISIEGIMADGEYFPIAIHDKTPQIGFTETSH ITPSILDEEAKKKIVEAAKKANEGLGLQNCATHTEIKLMKNREPGLIESAARFAGWNM IPNIKKVFGLDMAQLLLDVLCFGKDADLPDGLLDQEPYYVADCHLYPQHFKQNGQIPE TAEDLVIEAIDIPDGLLKGDTEIVSFSAAAPGTSVDLTLFEAFNSIAAFELKGSNSQD VAESIRQIQQHAKLTAKYVLPV*" /label="bacD CDS" gene complement(3487924..3489342) /gene="bacD" /locus_tag="BSU_37710" /old_locus_tag="BSU37710" /label="bacD gene" CDS complement(3489361..3490122) /gene="bacC" /locus_tag="BSU_37720" /old_locus_tag="BSU37720" /EC_number="1.1.1.385" /function="16.8: Protect" /function="16.4: Excrete" /experiment="publication(s) with functional evidences, PMID:12372825, 15609023, 18957859, 19061923, 23317005, 25261512, 25472439, 26284661, 28158843" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12372825, 15609023, 18957859, 19061923, 23317005, 25261512, 25472439, 26284661, 28158843; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydroanticapsin 7-dehydrogenase" /protein_id="NP_391652.2" /db_xref="EnsemblGenomes-Gn:BSU37720" /db_xref="EnsemblGenomes-Tr:CAB15799" /db_xref="GOA:P39640" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="PDB:5ITV" /db_xref="PDB:5ITW" /db_xref="SubtiList:BG10628" /db_xref="UniProtKB/Swiss-Prot:P39640" /translation="MNLTDKTVLITGGASGIGYAAVQAFLGQQANVVVADIDEAQGEA MVRKENNDRLHFVQTDITDEAACQHAVESAVHTFGGLDVLINNAGIEIVAPIHEMELS DWNKVLQVNLTGMFLMSKHALKHMLAAGKGNIINTCSVGGLVAWPDIPAYNASKGGVL QLTKSMAVDYAKHQIRVNCVCPGIIDTPLNEKSFLENNEGTLEEIKKEKAKVNPLLRL GKPEEIANVMLFLASDLSSYMTGSAITADGGYTAQ*" /label="bacC CDS" gene complement(3489361..3490122) /gene="bacC" /locus_tag="BSU_37720" /old_locus_tag="BSU37720" /label="bacC gene" CDS complement(3490125..3490832) /gene="bacB" /locus_tag="BSU_37730" /old_locus_tag="BSU37730" /EC_number="5.3.3.19" /function="16.4: Excrete" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12372825, 14697267, 15609023, 15628860, 18957859, 19061923, 19776011, 20445239, 22483065, 22765234, 25261512, 25472439, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12372825, 14697267, 15609023, 15628860, 18957859, 19061923, 19776011, 20445239, 22483065, 22765234, 25261512, 25472439, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-((4R)-4-hydroxycyclohexa-1, 5-dien-1-yl)-2-oxopropanoate isomerase" /protein_id="NP_391653.1" /db_xref="EnsemblGenomes-Gn:BSU37730" /db_xref="EnsemblGenomes-Tr:CAB15800" /db_xref="GOA:P39639" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR013096" /db_xref="InterPro:IPR014710" /db_xref="PDB:3H7J" /db_xref="PDB:3H7Y" /db_xref="PDB:3H9A" /db_xref="SubtiList:BG10627" /db_xref="UniProtKB/Swiss-Prot:P39639" /translation="MKTKEDMQELYFPTPKLIEWENGVRQYSTVRGDTEVLMSYVPPH TNVEPHQHKEVQIGMVVSGELMMTVGDVTRKMTALESAYIAPPHVPHGARNDTDQEVI AIDIKRLKADETYTSPEDYFLDIFKTRDLLPGMEVTFFVEDWVEIMLAKIPGNGGEMP FHKHRNEQIGICIGGGYDMTVEGCTVEMKFGTAYFCEPREDHGAINRSEKESKSINIF FPPRYNRAKAKKMKADE*" /label="bacB CDS" gene complement(3490125..3490832) /gene="bacB" /locus_tag="BSU_37730" /old_locus_tag="BSU37730" /label="bacB gene" misc_feature complement(3490728..3490729) /Source="Nicolas_upshift_promotors" /id="U2966" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.362637362637363" /psig="0.346653346653347" /xcortree=314 /SigmaFactorBS="cgaaattaattgaatgggaaaacggagtgaggcagtattcaa ccgtacgaggggatactgAAgtattaatgtcttacgtcccgccgcataccaatgttga a" /listShort="bacC, bacD, bacE, bacF" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3490729) /Source="Nicolas_upshifts" /id="U2966" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.362637362637363" /psig="0.346653346653347" /xcortree=314 /SigmaFactorBS="cgaaattaattgaatgggaaaacggagtgaggcagtattcaa ccgtacgaggggatactgAAgtattaatgtcttacgtcccgccgcataccaatgttga a" /listShort="bacC, bacD, bacE, bacF" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3490822..3491436) /gene="bacA" /locus_tag="BSU_37740" /old_locus_tag="BSU37740" /EC_number="4.1.1.100" /function="16.4: Excrete" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12372825, 15609023, 19776011, 18957859, 19061923, 20052993, 20863139, 25261512, 25472439, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12372825, 15609023, 19776011, 18957859, 19061923, 20052993, 20863139, 25261512, 25472439, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="prephenate decarboxylase" /protein_id="NP_391654.1" /db_xref="EnsemblGenomes-Gn:BSU37740" /db_xref="EnsemblGenomes-Tr:CAB15801" /db_xref="GOA:P39638" /db_xref="SubtiList:BG10626" /db_xref="UniProtKB/Swiss-Prot:P39638" /translation="MIILDNSIQTKKRTDSLSKLITVNTLGPEGTSSEYAAKHFISNF TLLQGLNSKLSLHDTFESCIERTLQSPLEYTIVPHAYDGIKHFYMRPDLQLLQIFRCD TPMYGLAVRPDFEFRDDMLDTSVIVSHPSPINLIKYFTRKDVRFKLVNSTSQAARKVK EGLYDIALTNELARQKYGLTFVKTFKSIPMSWSLFGKGDVDDEN*" /label="bacA CDS" gene complement(3490822..3491436) /gene="bacA" /locus_tag="BSU_37740" /old_locus_tag="BSU37740" /label="bacA gene" promotor_-35 3490994..3491000 /Source="Nicolas_upshift_promotors" /id="U2967" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=185 /SigmaFactorBS="cttgcggcttgactggttgaattgactAGTTTGAaacgaaca tctttgcGGGTAAAATATTTTATTAAattaataggtgaaggatgtgaaacaataacag a" /listShort="S1459" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3491016..3491034 /Source="Nicolas_upshift_promotors" /id="U2967" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=185 /SigmaFactorBS="cttgcggcttgactggttgaattgactAGTTTGAaacgaaca tctttgcGGGTAAAATATTTTATTAAattaataggtgaaggatgtgaaacaataacag a" /listShort="S1459" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3491027..3491638 /Source="Nicolas_S_feature" /locus_tag="new_3873771_3874382" /HighExp="Etha, Salt, Gly, Heat, C30, LPhT, HiTm, C90, S8, M/G" /AntisenseName="bacA" /AntisenseCor="9.8443047207874598E-2" /AntisenseRegPval="-1" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1459" upshifts 3491027 /Source="Nicolas_upshifts" /id="U2967" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=185 /SigmaFactorBS="cttgcggcttgactggttgaattgactAGTTTGAaacgaaca tctttgcGGGTAAAATATTTTATTAAattaataggtgaaggatgtgaaacaataacag a" /listShort="S1459" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3491459..3491478) /Source="Nicolas_upshift_promotors" /id="U2968" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2947 /SigmaFactorBS="tttgtatgggaataattatcaatattttcaaaaaaCATTGAC AgttcaatttccactGGATAAAATTTACTTAAAATtttaaaagattggttggtgctca t" /listShort="bacA, bacB, bacC, bacD, bacE, bacF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3491475) /Source="Nicolas_upshifts" /id="U2968" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2947 /SigmaFactorBS="tttgtatgggaataattatcaatattttcaaaaaaCATTGAC AgttcaatttccactGGATAAAATTTACTTAAAATtttaaaagattggttggtgctca t" /listShort="bacA, bacB, bacC, bacD, bacE, bacF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3491493..3491500) /Source="Nicolas_upshift_promotors" /id="U2968" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2947 /SigmaFactorBS="tttgtatgggaataattatcaatattttcaaaaaaCATTGAC AgttcaatttccactGGATAAAATTTACTTAAAATtttaaaagattggttggtgctca t" /listShort="bacA, bacB, bacC, bacD, bacE, bacF" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3491587) /Source="Nicolas_upshifts" /id="D1956" /incds=0 /nref=1 /ntot=33 /MaxReadThrough="2.28302" /MaxDrop="5.44594" /score="19.4538123" /energy="-5.1" /TU="NA" /idTUdmin="U2969" /TUdmin=902 /isTUend="FALSE" /label="downshifts" CDS complement(3491588..3492826) /gene="ywfA" /locus_tag="BSU_37750" /old_locus_tag="BSU37750" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15609023, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_391655.1" /db_xref="EnsemblGenomes-Gn:BSU37750" /db_xref="EnsemblGenomes-Tr:CAB15802" /db_xref="GOA:P39637" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10625" /db_xref="UniProtKB/Swiss-Prot:P39637" /translation="MNSNQNNDIKTKHHFPLLLALALTMGVFAAGSEELVISPLLPDL AKAFSSDVSVLALSISIYGVMIFIGAPLLVPLGDKYSRELSLLAGLMIFIIGTVICAL AQNIFFFFLGRALSGLAAGAFVPTAYAVVGDRVPYTYRGKVMGLIVSSWSLALIFGVP LGSFIGGVLHWRWTFWIFALMGVLVVLLILLEMRRHAQHKNSGKEEIEEPAGTFRDAL KVPRVPVYITITFCNMIGFYGMYSFLGTYLQDVFTGGNTAAGLFIMIYGIGFSMSVIT GKIADRIGKMRSLLIALGVISVLLACLPYAPASMFLLIASLFIWGLMQSLTVTLLSTI LSDCSERHRGKVMVFYSLASNLAVTLGSALMGPVYVAYGYAAVGLICAAITVLGFVLS VFAYKKYGKLEQKADQSLSQ*" /label="ywfA CDS" gene complement(3491588..3492826) /gene="ywfA" /locus_tag="BSU_37750" /old_locus_tag="BSU37750" /label="ywfA gene" promotor_-10 complement(3492868..3492887) /Source="Nicolas_upshift_promotors" /id="U2969" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.72027972027972" /psig="0.988011988011988" /xcortree=756 /SigmaFactorBS="gaaaataataaaacttataaatatttcgttcgaaTTGTAAAT agagaaaaaacAATGCTAAACTATAATACAActttatgataagaagattatggaagag g" /listShort="ywfA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3492880) /Source="Nicolas_upshifts" /id="U2969" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.72027972027972" /psig="0.988011988011988" /xcortree=756 /SigmaFactorBS="gaaaataataaaacttataaatatttcgttcgaaTTGTAAAT agagaaaaaacAATGCTAAACTATAATACAActttatgataagaagattatggaagag g" /listShort="ywfA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3492899..3492906) /Source="Nicolas_upshift_promotors" /id="U2969" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.72027972027972" /psig="0.988011988011988" /xcortree=756 /SigmaFactorBS="gaaaataataaaacttataaatatttcgttcgaaTTGTAAAT agagaaaaaacAATGCTAAACTATAATACAActttatgataagaagattatggaagag g" /listShort="ywfA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3493036..3494448) /gene="rocC" /locus_tag="BSU_37760" /old_locus_tag="BSU37760" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 7540694, 8113162, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="basic aminoacid permease" /protein_id="NP_391656.1" /db_xref="EnsemblGenomes-Gn:BSU37760" /db_xref="EnsemblGenomes-Tr:CAB15803" /db_xref="GOA:P39636" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG10624" /db_xref="UniProtKB/Swiss-Prot:P39636" /translation="MQNHKNELQRSMKSRHLFMIALGGVIGTGLFLGSGFTISQAGPL GAIAAYIIGGFLMYLVMLCLGELAVAMPVAGSFQAYATKFLGQSTGFMIGWLYWFSWA NTVGLELTSAGILMQRWLPSVPIWIWCLVFGIVIFLINALSVRSFAEMEFWFSSIKVA AIILFIVIGGAAVFGLIDFKGGQETPFLSNFMTDRGLFPNGVLAVMFTLVMVNFSFQG TELVGIAAGESESPEKTLPKSIRNVIWRTLFFFVLAMFVLVAILPYKTAGVIESPFVA VLDQIGIPFSADIMNFVILTAILSVANSGLYAASRMMWSLSSNQMGPSFLTRLTKKGV PMNALLITLGISGCSLLTSVMAAETVYLWCISISGMVTVVAWMSICASQFFFRRRFLA EGGNVNDLEFRTPLYPLVPILGFCLYGCVLISLIFIPDQRIGLYCGVPIIIFCYAYYH LSIKKRINHETIEKKQTEAQ*" /label="rocC CDS" gene complement(3493036..3494448) /gene="rocC" /locus_tag="BSU_37760" /old_locus_tag="BSU37760" /label="rocC gene" downshifts complement(3493043) /Source="Nicolas_upshifts" /id="D1957" /incds=0 /nref=16 /ntot=112 /MaxReadThrough="1.06691" /MaxDrop="5.69562" /score="41.626335" /energy="-15.9" /TU="NA" /idTUdmin="U2971" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(3494448..3496148) /gene="rocB" /locus_tag="BSU_37770" /old_locus_tag="BSU37770" /EC_number="3.5.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8113162; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-deacylase involved in arginine and ornithine utilization" /protein_id="NP_391657.1" /db_xref="EnsemblGenomes-Gn:BSU37770" /db_xref="EnsemblGenomes-Tr:CAB15804" /db_xref="GOA:P39635" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR012166" /db_xref="SubtiList:BG10623" /db_xref="UniProtKB/Swiss-Prot:P39635" /translation="MQYTKISHMNPAERVEALTASLVSLSSVNGTVGEGTKADFIKEV ITSYPYFQENPSHVWEQAIPNDPYKRKNIFAFIKGHGESRNTVIYHAHLDTVGIEDFG PLKDIAFDCEKLAEYFSRYEFDQDVQRDAKSGEWMFGRGSVDMQSGIAVHLANLLHFS ENLETLPGNVLFMANPDEESQHSGILASISELNRLKKEKQLHYLAAINTDFITPLYDG DQTRYIYTGAAGKLLPCFYIYGREVHVGDTLAGIDPNFISSEITSRLHNNIHLAEKVE GELVLPPSCLYQRDNKESYNVQTAVSTSLYFNCFIYERTAKEMMDLLIEVTEEACRET EQKLSDYYEEYVKRANLPKKHLSWGIQVYSLEQYLEKLRNRGIDPEQCIEQTFKANEH LELRMRCFQAIEELQKLDPDQGAKVILFYAPPYLPHNYLKEDSARDQLLQHVIKEAAD KTAESTGETFVFKKFFPYLADGSFLSLHETDGEIDSFIRNFPGWNMIGTIPFKDIRKL NIPSINMGVYGKDGHKWTERVYKPYTFHVLPLLIQQTTVHLLQSYRMTITAKEPKGEG *" /label="rocB CDS" gene complement(3494448..3496148) /gene="rocB" /locus_tag="BSU_37770" /old_locus_tag="BSU37770" /label="rocB gene" misc_feature complement(3495117..3495133) /Source="Nicolas_upshift_promotors" /id="U2970" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.238761238761239" /psig="0.613386613386613" /xcortree=2859 /SigmaFactorBS="ggatttgcttattgaagtcactgaggaagcatgccgggagac agaacaaaaattatCAGATTATTACGAAGAAtatgtaaaaagagccaacctgccaaag a" /listShort="rocC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3495129) /Source="Nicolas_upshifts" /id="U2970" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.238761238761239" /psig="0.613386613386613" /xcortree=2859 /SigmaFactorBS="ggatttgcttattgaagtcactgaggaagcatgccgggagac agaacaaaaattatCAGATTATTACGAAGAAtatgtaaaaagagccaacctgccaaag a" /listShort="rocC" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3496222..3497769) /gene="rocA" /locus_tag="BSU_37780" /old_locus_tag="BSU37780" /EC_number="1.2.1.88" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11418582, 12634342, 8113162, 9383188, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="delta-1-pyrroline-5 carboxylate dehydrogenase" /protein_id="NP_391658.1" /db_xref="EnsemblGenomes-Gn:BSU37780" /db_xref="EnsemblGenomes-Tr:CAB15805" /db_xref="GOA:P39634" /db_xref="InterPro:IPR005932" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG10622" /db_xref="UniProtKB/Swiss-Prot:P39634" /translation="MTVTYAHEPFTDFTEAKNKTAFGESLAFVNTQLGKHYPLVINGE KIETDRKIISINPANKEEIIGYASTADQELAEKAMQAALQAFDSWKKQRPEHRANILF KAAAILRRRKHEFSSYLVKEAGKPWKEADADTAEAIDFLEFYARQMLKLKEGAPVKSR AGEVNQYHYEALGVGIVISPFNFPLAIMAGTAVAAIVTGNTILLKPADAAPVVAAKFV EVMEEAGLPNGVLNYIPGDGAEIGDFLVEHPKTRFVSFTGSRAVGCRIYERAAKVQPG QKWLKRVIAEMGGKDTVLVDKDADLDLAASSIVYSAFGYSGQKCSAGSRAVIHQDVYD EVVEKAVALTKTLTVGNPEDPDTYMGPVIHEASYNKVMKYIEIGKSEGKLLAGGEGDD SKGYFIQPTIFADVDENARLMQEEIFGPVVAICKARDFDHMLEIANNTEYGLTGALLT KNRAHIERAREDFHVGNLYFNRGCTGAIVGYQPFGGFNMSGTDSKAGGPDYLILHMQA KTTSEAF*" /label="rocA CDS" gene complement(3496222..3497769) /gene="rocA" /locus_tag="BSU_37780" /old_locus_tag="BSU37780" /label="rocA gene" downshifts complement(3496229) /Source="Nicolas_upshifts" /id="D1958" /incds=0 /nref=4 /ntot=50 /MaxReadThrough="5.60027" /MaxDrop="3.5628" /score="41.626335" /energy="-15.9" /TU="U2971,U2972" /idTUdmin="U2973" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(3497813) /Source="Nicolas_upshifts" /id="U2971" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.874125874125874" /psig="0.874125874125874" /xcortree=2703 /SigmaFactorBS="gttcgattcaacaagttttttcagcaaaagacaagaaaaTGG CATGATTCTTGCATTTttattcatatgcgaagatatatttcataacacgagggggact a" /listShort="rocA, rocB, rocC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3497815..3497995) /Source="Nicolas_S_feature" /locus_tag="new_3880559_3880739_c" /HighExp="S0, Lbstat, T1.30H, T2.0H, T1.0H, BI, T2.30H, M0t90, M40t90, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigL, SigA" /TUshortPSig="0.864, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1460" misc_feature complement(3497816..3497834) /Source="Nicolas_upshift_promotors" /id="U2971" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.874125874125874" /psig="0.874125874125874" /xcortree=2703 /SigmaFactorBS="gttcgattcaacaagttttttcagcaaaagacaagaaaaTGG CATGATTCTTGCATTTttattcatatgcgaagatatatttcataacacgagggggact a" /listShort="rocA, rocB, rocC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(3497996..3499270) /gene="rocG" /locus_tag="BSU_37790" /old_locus_tag="BSU37790" /EC_number="1.4.1.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9829940, 10468601, 12634342, 15150224, 17183217, 17608797, 18326565, 20630473, 22178969, 22625175, 25711804, 28193334" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9829940, 10468601, 12634342, 15150224, 17183217, 17608797, 18326565, 20630473, 22178969, 22625175, 25711804, 28193334; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate dehydrogenase" /protein_id="NP_391659.2" /db_xref="EnsemblGenomes-Gn:BSU37790" /db_xref="EnsemblGenomes-Tr:CAB15806" /db_xref="GOA:P39633" /db_xref="InterPro:IPR006095" /db_xref="InterPro:IPR006096" /db_xref="InterPro:IPR006097" /db_xref="InterPro:IPR014362" /db_xref="InterPro:IPR033524" /db_xref="InterPro:IPR033922" /db_xref="InterPro:IPR036291" /db_xref="PDB:3K92" /db_xref="SubtiList:BG10621" /db_xref="UniProtKB/Swiss-Prot:P39633" /translation="MSAKQVSKDEEKEALNLFLSTQTIIKEALRKLGYPGDMYELMKE PQRMLTVRIPVKMDNGSVKVFTGYRSQHNDAVGPTKGGVRFHPEVNEEEVKALSIWMT LKCGIANLPYGGGKGGIICDPRTMSFGELERLSRGYVRAISQIVGPTKDIPAPDVYTN SQIMAWMMDEYSRLREFDSPGFITGKPLVLGGSQGRETATAQGVTICIEEAVKKKGIK LQNARIIIQGFGNAGSFLAKFMHDAGAKVIGISDANGGLYNPDGLDIPYLLDKRDSFG MVTNLFTDVITNEELLEKDCDILVPAAISNQITAKNAHNIQASIVVEAANGPTTIDAT KILNERGVLLVPDILASAGGVTVSYFEWVQNNQGYYWSEEEVAEKLRSVMVSSFETIY QTAATHKVDMRLAAYMTGIRKSAEASRFRGWV*" /label="rocG CDS" gene complement(3497996..3499270) /gene="rocG" /locus_tag="BSU_37790" /old_locus_tag="BSU37790" /label="rocG gene" S_feature complement(3499271..3499353) /Source="Nicolas_S_feature" /locus_tag="new_3882015_3882097_c" /HighExp="S0, Lbstat, T1.30H, T2.0H, T1.0H, BI, T2.30H, M0t90, M40t90, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.83780600000000005" /TUshortSig="SigL, SigA" /TUshortPSig="0.864, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1461" upshifts complement(3499353) /Source="Nicolas_upshifts" /id="U2972" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.864135864135864" /psig="0.864135864135864" /xcortree=393 /SigmaFactorBS="tcagtctctttttttgtggattcaaaagcTGGTACGGATCTT GCATGAtgataagggtgaatccaatgaagaaaggaattggcgggctgattttttaaag c" /listShort="S1461, rocG, S1460, rocA, rocB, rocC" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(3499366..3499384) /Source="Nicolas_upshift_promotors" /id="U2972" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.864135864135864" /psig="0.864135864135864" /xcortree=393 /SigmaFactorBS="tcagtctctttttttgtggattcaaaagcTGGTACGGATCTT GCATGAtgataagggtgaatccaatgaagaaaggaattggcgggctgattttttaaag c" /listShort="S1461, rocG, S1460, rocA, rocB, rocC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" downshifts complement(3499446) /Source="Nicolas_upshifts" /id="D1959" /incds=0 /nref=9 /ntot=144 /MaxReadThrough="4.82066" /MaxDrop="4.13762" /score="22.6949864" /energy="-11.4" /TU="U2973" /idTUdmin="U2977" /TUdmin=369 /isTUend="FALSE" /label="downshifts" CDS complement(3499447..3499911) /gene="bslB" /locus_tag="BSU_37800" /old_locus_tag="BSU37800" /experiment="publication(s) with functional evidences, PMID:15187182, 28751732" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15187182, 28751732; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="biofilm protein, member of the processed secretome contributing to biofilm hydrophobicity" /protein_id="NP_391660.1" /db_xref="EnsemblGenomes-Gn:BSU37800" /db_xref="EnsemblGenomes-Tr:CAB15807" /db_xref="GOA:P39632" /db_xref="InterPro:IPR034650" /db_xref="PDB:5MKD" /db_xref="SubtiList:BG10620" /db_xref="UniProtKB/Swiss-Prot:P39632" /translation="MLKRTSFVSSLFISSAVLLSILLPSGQAHAQSASIEAKTVNSTK EWTISDIEVTYKPNAVLSLGAVEFQFPDGFHATTRDSVNGRTLKETQILNDGKTVRLP LTLDLLGASEFDLVMVRKTLPRAGTYTIKGDVVNGLGIGSFYAETQLVIDPR*" /label="bslB CDS" gene complement(3499447..3499911) /gene="bslB" /locus_tag="BSU_37800" /old_locus_tag="BSU37800" /label="bslB gene" S_feature complement(3499912..3500022) /Source="Nicolas_S_feature" /locus_tag="new_3882656_3882766_c" /HighExp="C90, S1, S0, MG 150, M9-tran, LPhT, BI, GM 150, Lbtran, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1462" promotor_-10 complement(3500004..3500023) /Source="Nicolas_upshift_promotors" /id="U2973" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.964035964035964" /psig="0.999000999001" /xcortree=2719 /SigmaFactorBS="tctcattgaattccaagtgttaatattccttaaaaaaCATTT ACTtccatggaaaatgaTGATAGATTAATTTTTAAGAaaaagaactggtaattcgcga a" /listShort="S1462, yweA, S1461, rocG, S1460, rocA" /listLong="rocB, rocC" /label="promotor_-10" upshifts complement(3500022) /Source="Nicolas_upshifts" /id="U2973" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.964035964035964" /psig="0.999000999001" /xcortree=2719 /SigmaFactorBS="tctcattgaattccaagtgttaatattccttaaaaaaCATTT ACTtccatggaaaatgaTGATAGATTAATTTTTAAGAaaaagaactggtaattcgcga a" /listShort="S1462, yweA, S1461, rocG, S1460, rocA" /listLong="rocB, rocC" /label="upshifts" promotor_-35 complement(3500038..3500045) /Source="Nicolas_upshift_promotors" /id="U2973" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.964035964035964" /psig="0.999000999001" /xcortree=2719 /SigmaFactorBS="tctcattgaattccaagtgttaatattccttaaaaaaCATTT ACTtccatggaaaatgaTGATAGATTAATTTTTAAGAaaaagaactggtaattcgcga a" /listShort="S1462, yweA, S1461, rocG, S1460, rocA" /listLong="rocB, rocC" /label="promotor_-35" downshifts complement(3500233) /Source="Nicolas_upshifts" /id="D1960" /incds=0 /nref=32 /ntot=80 /MaxReadThrough="3.01999" /MaxDrop="4.92444" /score="6.35246869" /energy="-8.4" /TU="U2977" /idTUdmin="U2977" /TUdmin="-418" /isTUend="FALSE" /label="downshifts" CDS complement(3500235..3500690) /gene="spsL" /locus_tag="BSU_37810" /old_locus_tag="BSU37810" /EC_number="5.1.3.13" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 25239894; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dTDP-4-deoxyrhamnose-3,5-epimerase (cell surface and spore coat)" /protein_id="YP_054595.1" /db_xref="EnsemblGenomes-Gn:BSU37810" /db_xref="EnsemblGenomes-Tr:CAE01469" /db_xref="GOA:Q7WY56" /db_xref="InterPro:IPR000888" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="SubtiList:BG14195" /db_xref="UniProtKB/Swiss-Prot:Q7WY56" /translation="MIDGVKVKKLMKHSDDRGFFAELVRDDENLLEHFGQASWSKSYP GVIKAFHYHEKQDDLWFFPTGHAQVVLYDLREDSKTKGETDVYYMGEDNPMLLLIPKG VAHGYRVLGETPLTIIYFTTMSYNPDQPDEKRIPWDDETIGFNWNTEFR*" /label="spsL CDS" gene complement(3500235..3500690) /gene="spsL" /locus_tag="BSU_37810" /old_locus_tag="BSU37810" /label="spsL gene" misc_feature 3500325..3500344 /Source="Nicolas_upshift_promotors" /id="U2974" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=2855 /SigmaFactorBS="catcatcccacggaattcttttttcatcaggctgatccgggt tatacgacatGGTGGTAAAATAGATAATTGtcagcggcgtctctcccagcactctata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3500333 /Source="Nicolas_upshifts" /id="U2974" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=2855 /SigmaFactorBS="catcatcccacggaattcttttttcatcaggctgatccgggt tatacgacatGGTGGTAAAATAGATAATTGtcagcggcgtctctcccagcactctata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3500683..3501534) /gene="spsK" /locus_tag="BSU_37820" /old_locus_tag="BSU37820" /EC_number="1.1.1.133" /function="16.13: Shape" /function="16.8: Protect" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dTDP-4-dehydrorhamnose reductase" /protein_id="NP_391661.3" /db_xref="EnsemblGenomes-Gn:BSU37820" /db_xref="EnsemblGenomes-Tr:CAB15808" /db_xref="GOA:P39631" /db_xref="InterPro:IPR005913" /db_xref="InterPro:IPR029903" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10619" /db_xref="UniProtKB/Swiss-Prot:P39631" /translation="MTKVLVTGAGGQLGLELCRQLKQAGYEVIALTKKMMNIADQRSV RHSFGHYQPDIVVNSAAFTSVDQCEKELDKAYLINGIGAYYTALESTRIGAQYVHIST DYVFNGKGTQPYREDDPLDPKTIYGKSKRLGEELIRLTTKDSTIIRTSWVYGHGGSNF VETMLKLAETKQELRVVSDQIGSPTYTKDLAEAVIKLFSHPPGIYHVSNSGICSWYEF ATAIMEESGLETAILSVTTEEYGNKTPRPAYSVLSHRAIEEAGIRPRHWREALREYLQ ERSSACD*" /label="spsK CDS" gene complement(3500683..3501534) /gene="spsK" /locus_tag="BSU_37820" /old_locus_tag="BSU37820" /label="spsK gene" CDS complement(3501548..3502495) /gene="spsJ" /locus_tag="BSU_37830" /old_locus_tag="BSU37830" /EC_number="4.2.1.46" /function="16.8: Protect" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:22960854" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22960854; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dTDP-glucose 4,6-dehydratase" /protein_id="NP_391662.1" /db_xref="EnsemblGenomes-Gn:BSU37830" /db_xref="EnsemblGenomes-Tr:CAB15809" /db_xref="GOA:P39630" /db_xref="InterPro:IPR005888" /db_xref="InterPro:IPR016040" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10618" /db_xref="UniProtKB/Swiss-Prot:P39630" /translation="MAKSYLITGGAGFIGLTFTKLMLRETDARITVLDKLTYASHPEE MEKLKQNSRFRFVKGDISVQEDIDRAFDETYDGVIHFAAESHVDRSISQAEPFITTNV MGTYRLAEAVLKGKAKKLIHISTDEVYGDLKADDPAFTETTPLSPNNPYSASKASSDL LVLSYVKTHKLPAIITRCSNNYGPYQHSEKMIPTIIRHAKQGLPVPLYGDGLQIRDWL FAEDHCRAIKLILEKGTDGEVYNIGGGNERTNKELASVILKHLGCEELFAHVEDRKGH DRRYAINASKLKNELGWRQEVTFEEGIARTIQWYTDNDR*" /label="spsJ CDS" gene complement(3501548..3502495) /gene="spsJ" /locus_tag="BSU_37830" /old_locus_tag="BSU37830" /label="spsJ gene" CDS complement(3502495..3503235) /gene="spsI" /locus_tag="BSU_37840" /old_locus_tag="BSU37840" /EC_number="2.7.7.24" /function="16.8: Protect" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:22960854" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22960854; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucose-1-phosphate thymidylyltransferase" /protein_id="NP_391663.1" /db_xref="EnsemblGenomes-Gn:BSU37840" /db_xref="EnsemblGenomes-Tr:CAB15810" /db_xref="GOA:P39629" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR005907" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10617" /db_xref="UniProtKB/Swiss-Prot:P39629" /translation="MKGVILAGGNGSRLMPLTKAVNKHLLPVGPYPMIYWSIMKLQEA GIKDILLISQKEHMPQFYKLLGNGEELGVTITYQVQPAASGISDGLSYAKRFTKKESF ILLLGDNIFEDSLKPYTERFEQQGKGAKVLLKEVDDPERFGIAEIDEKNKRIRSIIEK PEQPPTNLCVTGIYMYDAEVFSYIEQISPSKRGELEITDVNNLYIENSQLTYDVLSGW WVDAGTHESLYLASQLVHQALRKGQDEK*" /label="spsI CDS" gene complement(3502495..3503235) /gene="spsI" /locus_tag="BSU_37840" /old_locus_tag="BSU37840" /label="spsI gene" promotor_-35 3503253..3503258 /Source="Nicolas_upshift_promotors" /id="U2975" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.89010989010989" /psig="0.89010989010989" /xcortree=953 /SigmaFactorBS="gtgagccgtttcctccggctaaaataacacctttcacattaa cacttccttacaTGCATTtttatatctcttgtTCATATAAATCTTGAAGAAtagctgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3503259 /Source="Nicolas_upshifts" /id="U2975" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.89010989010989" /psig="0.89010989010989" /xcortree=953 /SigmaFactorBS="gtgagccgtttcctccggctaaaataacacctttcacattaa cacttccttacaTGCATTtttatatctcttgtTCATATAAATCTTGAAGAAtagctgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3503260..3504279) /gene="spsG" /locus_tag="BSU_37850" /old_locus_tag="BSU37850" /function="16.13: Shape" /function="16.8: Protect" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_391664.1" /db_xref="EnsemblGenomes-Gn:BSU37850" /db_xref="EnsemblGenomes-Tr:CAB15811" /db_xref="GOA:P39627" /db_xref="InterPro:IPR007235" /db_xref="SubtiList:BG10615" /db_xref="UniProtKB/Swiss-Prot:P39627" /translation="MHVGIFADGGYEKGMGHVVRMKRLAEGLKQRCLITFYTNQDSEA FLHEEHWQVIVKPELQQHEFILREIKSKKLDLLLFDILGAPAELLKKIKTETDAKIVL FEEKNGKSIQYSDAVINGIYGDIRSRVYVQGNTRIYEGPDYLILHPAFQAAREDYTLK KDCRNILVALGGSDPKQLIFKVLAAADQVPDIKDKNMMFVMGSASPHQEAVRRRIEKK PQYKMIEQTNDMAGLMKQADAAIVAGGISLYEAICIGVPCLVLSQVEHQTATAKTFAD QGAALDLGLGELVPDETLIYQMSRIMSSYPLRLSLHKGGRPLVDGKGIIRVTAILQDL YEQEI*" /label="spsG CDS" gene complement(3503260..3504279) /gene="spsG" /locus_tag="BSU_37850" /old_locus_tag="BSU37850" /label="spsG gene" promotor_-10 3503273..3503291 /Source="Nicolas_upshift_promotors" /id="U2975" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.89010989010989" /psig="0.89010989010989" /xcortree=953 /SigmaFactorBS="gtgagccgtttcctccggctaaaataacacctttcacattaa cacttccttacaTGCATTtttatatctcttgtTCATATAAATCTTGAAGAAtagctgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 3504143..3504152 /Source="Nicolas_upshift_promotors" /id="U2976" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1682 /SigmaFactorBS="acgatgacctgccaatgctcttcatgaAGAAACGCTTcagaa tcctgatTCGTATAAAACGTAATcaagcatcgctgtttgagcccctccgcaagcctct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3504165..3504180 /Source="Nicolas_upshift_promotors" /id="U2976" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1682 /SigmaFactorBS="acgatgacctgccaatgctcttcatgaAGAAACGCTTcagaa tcctgatTCGTATAAAACGTAATcaagcatcgctgtttgagcccctccgcaagcctct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3504176 /Source="Nicolas_upshifts" /id="U2976" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1682 /SigmaFactorBS="acgatgacctgccaatgctcttcatgaAGAAACGCTTcagaa tcctgatTCGTATAAAACGTAATcaagcatcgctgtttgagcccctccgcaagcctct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3504282..3505004) /gene="spsF" /locus_tag="BSU_37860" /old_locus_tag="BSU37860" /EC_number="2.-.-.-" /function="16.8: Protect" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_391665.2" /db_xref="EnsemblGenomes-Gn:BSU37860" /db_xref="EnsemblGenomes-Tr:CAB15812" /db_xref="InterPro:IPR003329" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10614" /db_xref="UniProtKB/Swiss-Prot:P39626" /translation="MNDILFIIQARMGSTRLPGKVLRPLGSNRLLDILVHRVRQSAFY QKDRDNLVIATSDKETDDILEAHCIKQGFRVFRGSEERVLDRFVKVIEAVKPSVIIRL TGDNPFVDPELLDVMIQAHFDQGSDYTYILNAPLGICGEVVNANLLIDISRIQALEDQ YQEHVTLYIRNHPALYRVQFLEAPERFRAPQYRLTIDTKEDYESIKALYQKAGERPDV SASELITLLNRNPDAATEREAD*" /label="spsF CDS" gene complement(3504282..3505004) /gene="spsF" /locus_tag="BSU_37860" /old_locus_tag="BSU37860" /label="spsF gene" CDS complement(3504997..3506118) /gene="spsE" /locus_tag="BSU_37870" /old_locus_tag="BSU37870" /EC_number="2.5.-.-" /function="16.13: Shape" /function="16.8: Protect" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12597896, 15774001; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphoenolpyruvate-sugar pyruvyltransferase" /protein_id="NP_391666.1" /db_xref="EnsemblGenomes-Gn:BSU37870" /db_xref="EnsemblGenomes-Tr:CAB15813" /db_xref="GOA:P39625" /db_xref="InterPro:IPR006190" /db_xref="InterPro:IPR013132" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR013974" /db_xref="InterPro:IPR036732" /db_xref="PDB:1VLI" /db_xref="SubtiList:BG10613" /db_xref="UniProtKB/Swiss-Prot:P39625" /translation="MAAFQIANKTVGKDAPVFIIAEAGINHDGKLDQAFALIDAAAEA GADAVKFQMFQADRMYQKDPGLYKTAAGKDVSIFSLVQSMEMPAEWILPLLDYCREKQ VIFLSTVCDEGSADLLQSTSPSAFKIASYEINHLPLLKYVARLNRPMIFSTAGAEISD VHEAWRTIRAEGNNQIAIMHCVAKYPAPPEYSNLSVIPMLAAAFPEAVIGFSDHSEHP TEAPCAAVRLGAKLIEKHFTIDKNLPGADHSFALNPDELKEMVDGIRKTEAELKQGIT KPVSEKLLGSSYKTTTAIEGEIRNFAYRGIFTTAPIQKGEAFSEDNIAVLRPGQKPQG LHPRFFELLTSGVRAVRDIPADTGIVWDDILLKDSPFHE*" /label="spsE CDS" gene complement(3504997..3506118) /gene="spsE" /locus_tag="BSU_37870" /old_locus_tag="BSU37870" /label="spsE gene" CDS complement(3506118..3506987) /gene="spsD" /locus_tag="BSU_37880" /old_locus_tag="BSU37880" /EC_number="2.3.1.-" /function="16.5: Explore" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative TDP-glycosamine N-acetyltransferase" /protein_id="NP_391667.1" /db_xref="EnsemblGenomes-Gn:BSU37880" /db_xref="EnsemblGenomes-Tr:CAB15814" /db_xref="GOA:P39624" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG10612" /db_xref="UniProtKB/Swiss-Prot:P39624" /translation="MYTVKENVSKEAIEEFLQSRKLTLDVPYQFSLGLFENSRLQGVL LYEDSLWESKVLQKKVMNVKLLAANSTGQLKRLFEAFYTVRQMDETDFIFVRVPAEDI GAAHVIQQQPSSYFVGSLLKLAMPPSFYDKTPPFFELGPPEPGDTEAICELARDSFTK SRYFQDPHLSRDAANEIFQEWTRNNLNGRAAVNIVAKHNGEVIGYLQGLSRDDECILD LMAVKPGFEGKRIAFHLLANLIEQPETQKHRTVTAGTQLHNVRAIRLYERMGFTAEQS YYYYHIWPGKEAK*" /label="spsD CDS" gene complement(3506118..3506987) /gene="spsD" /locus_tag="BSU_37880" /old_locus_tag="BSU37880" /label="spsD gene" CDS complement(3506988..3508157) /gene="spsC" /locus_tag="BSU_37890" /old_locus_tag="BSU37890" /EC_number="2.6.1.-" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14602648; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glutamine-dependent sugar transaminase" /protein_id="NP_391668.1" /db_xref="EnsemblGenomes-Gn:BSU37890" /db_xref="EnsemblGenomes-Tr:CAB15815" /db_xref="GOA:P39623" /db_xref="InterPro:IPR000653" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG10611" /db_xref="UniProtKB/Swiss-Prot:P39623" /translation="MVQKRNHFLPYSLPLIGKEEIQEVTETLESGWLSKGPKVQQFEK EFAAFVGAKHAVAVNSCTAALFLALKAKGIGPGDEVITSPLTFSSTANTIIHTGATPV FADIDENTLNIDPVKLEAAVTPRTKAVVPVHFGGQSCDMDAILAVAQNHGLFVLEDAA HAVYTTYKQRMIGSIGDATAFSFYATKNLATGEGGMLTTDDEELADKIRVLSLHGMSK AAWNRYSSNGSWYYEVESPGYKMNMFDLQAALGLHQLKRLDDMQKRREEIAGRYQTAF QQIPGLITPFVHDDGRHAWHLYVLQVDEKKAGVTRSEMITALKDEYNIGTSVHFIPVH IHPYYQKQFGYKEADFPNAMNYYKRTLSLPLYPSMSDDDVDDVIEAVRDIVKGAD*" /label="spsC CDS" gene complement(3506988..3508157) /gene="spsC" /locus_tag="BSU_37890" /old_locus_tag="BSU37890" /label="spsC gene" CDS complement(3508178..3509602) /gene="spsB" /locus_tag="BSU_37900" /old_locus_tag="BSU37900" /function="16.5: Explore" /function="16.8: Protect" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22611084; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dTDP glycosyl/glycerophosphate transferase or transport" /protein_id="NP_391669.2" /db_xref="EnsemblGenomes-Gn:BSU37900" /db_xref="EnsemblGenomes-Tr:CAB15816" /db_xref="GOA:P39622" /db_xref="InterPro:IPR007554" /db_xref="SubtiList:BG10610" /db_xref="UniProtKB/Swiss-Prot:P39622" /translation="MSAYLSNYWVLYRKYVELFDKLRYKGIPLGLISNFYQYISPELR VMMEEEPELFGSVDQHIDEGQIQPFFEERIQNIVKTNDEPVKGKVILHFDYLRFSNEN YYQFDPEKTAVLARWSLPHYCDLPVISKREIADSCQKGDSKQYLETACSLLAPYDDHP AFGDQAFRDRLFKDIPLFIEAIDTVDALFEQEKISAVIVGTAEDIYSRVLALMCQRKG AVSICLQHGALMGDEAFIPVFTTYQAVFGAYEAEWFIRKGCKPEQILVTGHPRFDQIF NRTPMDMSIFYRKLAFQPTKKIVLIATQPFSEDFYSGVLQGLSDQKQLQIIIKPHPWE IGKNKLDLYHEAAKKHQACRVIKKELELYDLLPYVDAAVTQTSTVGLEAMLFQKPVLI GKSSGNRSYPYYESLGDFMFDQPDELAHTLVEVLRSPDVHQKAEEARLAFIAANYPVA ESTNALFAELKAKTGVDYRREDTE*" /label="spsB CDS" gene complement(3508178..3509602) /gene="spsB" /locus_tag="BSU_37900" /old_locus_tag="BSU37900" /label="spsB gene" CDS complement(3509607..3510377) /gene="spsA" /locus_tag="BSU_37910" /old_locus_tag="BSU37910" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10350455, 11042447, 11733986" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10350455, 11042447, 11733986; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore coat dTDP-glycosyltransferase" /protein_id="NP_391670.1" /db_xref="EnsemblGenomes-Gn:BSU37910" /db_xref="EnsemblGenomes-Tr:CAB15817" /db_xref="GOA:P39621" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="PDB:1H7L" /db_xref="PDB:1H7Q" /db_xref="PDB:1QG8" /db_xref="PDB:1QGQ" /db_xref="PDB:1QGS" /db_xref="SubtiList:BG10609" /db_xref="UniProtKB/Swiss-Prot:P39621" /translation="MPKVSVIMTSYNKSDYVAKSISSILSQTFSDFELFIMDDNSNEE TLNVIRPFLNDNRVRFYQSDISGVKERTEKTRYAALINQAIEMAEGEYITYATDDNIY MPDRLLKMVRELDTHPEKAVIYSASKTYHLNENRDIVKETVRPAAQVTWNAPCAIDHC SVMHRYSVLEKVKEKFGSYWDESPAFYRIGDARFFWRVNHFYPFYPLDEELDLNYITD QSIHFQLFELEKNEFVRNLPPQRNCRELRESLKKLGMG*" /label="spsA CDS" gene complement(3509607..3510377) /gene="spsA" /locus_tag="BSU_37910" /old_locus_tag="BSU37910" /label="spsA gene" promotor_-10 complement(3510412..3510431) /Source="Nicolas_upshift_promotors" /id="U2977" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1357 /SigmaFactorBS="atacacaaacttttcgcatattggtttgtatcCCTAGCGCAA cttgagcataagcAACATAAGATAACGATAGTTtcaggtgtgaagttccaagaaggag g" /listShort="spsA, spsB, spsC, spsD, spsE, spsF, spsG, spsI, spsJ, spsK, spsL, S1462, yweA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3510426) /Source="Nicolas_upshifts" /id="U2977" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1357 /SigmaFactorBS="atacacaaacttttcgcatattggtttgtatcCCTAGCGCAA cttgagcataagcAACATAAGATAACGATAGTTtcaggtgtgaagttccaagaaggag g" /listShort="spsA, spsB, spsC, spsD, spsE, spsF, spsG, spsI, spsJ, spsK, spsL, S1462, yweA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3510445..3510454) /Source="Nicolas_upshift_promotors" /id="U2977" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1357 /SigmaFactorBS="atacacaaacttttcgcatattggtttgtatcCCTAGCGCAA cttgagcataagcAACATAAGATAACGATAGTTtcaggtgtgaagttccaagaaggag g" /listShort="spsA, spsB, spsC, spsD, spsE, spsF, spsG, spsI, spsJ, spsK, spsL, S1462, yweA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3510545..3510550 /Source="Nicolas_upshift_promotors" /id="U2978" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1093 /SigmaFactorBS="cccagagcgaaatctgatcggtccgctgttctttttcAGCAT AatccaagcatcagccTCATAAGGTGAAAGAGATAaaaatcgcaccagcgactaagat c" /listShort="S1463, ywdL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3510566..3510584 /Source="Nicolas_upshift_promotors" /id="U2978" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1093 /SigmaFactorBS="cccagagcgaaatctgatcggtccgctgttctttttcAGCAT AatccaagcatcagccTCATAAGGTGAAAGAGATAaaaatcgcaccagcgactaagat c" /listShort="S1463, ywdL" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3510568..3510696 /Source="Nicolas_S_feature" /locus_tag="new_3893312_3893440" /HighExp="S5, S4, S3, S7, B36, S8, S6, B60, T5.0H, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1463" upshifts 3510568 /Source="Nicolas_upshifts" /id="U2978" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1093 /SigmaFactorBS="cccagagcgaaatctgatcggtccgctgttctttttcAGCAT AatccaagcatcagccTCATAAGGTGAAAGAGATAaaaatcgcaccagcgactaagat c" /listShort="S1463, ywdL" /GFF_Attribute="listLong" /label="upshifts" CDS 3510697..3511242 /gene="gerQ" /locus_tag="BSU_37920" /old_locus_tag="BSU37920" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12644503, 15317760, 16936016, 16936016, 19933362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12644503, 15317760, 16936016, 16936016, 19933362; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="inner spore coat protein" /protein_id="NP_391671.1" /db_xref="EnsemblGenomes-Gn:BSU37920" /db_xref="EnsemblGenomes-Tr:CAB15818" /db_xref="GOA:P39620" /db_xref="InterPro:IPR014099" /db_xref="SubtiList:BG10608" /db_xref="UniProtKB/Swiss-Prot:P39620" /translation="MKPKKNQYQQMQAFDNMQGYQPQFGANPYPQQGQGSQMQTMGMQ PMMPMQQGQQGQQGQQGFGFPGQQQGGGFQIPSGPTPSGPGQSVPGMLPVEESYIENI LRLNRGKTATIYMTFENSKEWGSKIFRGVIEAAGRDHIIISDPKSGTRYLLLTIYLDY ITFDEEIAYTYPYSMASYSPR*" /label="gerQ CDS" gene 3510697..3511242 /gene="gerQ" /locus_tag="BSU_37920" /old_locus_tag="BSU37920" /label="gerQ gene" downshifts 3511228 /Source="Nicolas_upshifts" /id="D1961" /incds=0 /nref=60 /ntot=77 /MaxReadThrough="1.98659" /MaxDrop="7.96105" /score="16.9179802" /energy="-11.7" /TU="NA" /idTUdmin="U2978" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3511286..3511657) /gene="ywdK" /locus_tag="BSU_37930" /old_locus_tag="BSU37930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15919996, 21810204; Product type m:membrane component" /codon_start=1 /transl_table=11 /product="conserved membrane protein" /protein_id="NP_391672.2" /db_xref="EnsemblGenomes-Gn:BSU37930" /db_xref="EnsemblGenomes-Tr:CAB15819" /db_xref="GOA:P39619" /db_xref="InterPro:IPR006696" /db_xref="SubtiList:BG10607" /db_xref="UniProtKB/Swiss-Prot:P39619" /translation="MKVFIILGAINALLAVGLGAFGAHGLEGKIPDKYLQVWHTGVQY HMYHALGLFVVAFLADKLSGIGSVTTAGWLMFAGIVLFSGSLYILSVTQISILGAITP LGGVAFIISWIMIVVAAVKYL*" /label="ywdK CDS" gene complement(3511286..3511657) /gene="ywdK" /locus_tag="BSU_37930" /old_locus_tag="BSU37930" /label="ywdK gene" downshifts complement(3511304) /Source="Nicolas_upshifts" /id="D1962" /incds=0 /nref=134 /ntot=227 /MaxReadThrough="3.65585" /MaxDrop="4.84049" /score="15.105437" /energy="-11.7" /TU="NA" /idTUdmin="U2979" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3511719..3513041) /gene="ywdJ" /locus_tag="BSU_37940" /old_locus_tag="BSU37940" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative purine/pyrimidine permease" /protein_id="NP_391673.2" /db_xref="EnsemblGenomes-Gn:BSU37940" /db_xref="EnsemblGenomes-Tr:CAB15820" /db_xref="GOA:P39618" /db_xref="InterPro:IPR006042" /db_xref="InterPro:IPR006043" /db_xref="SubtiList:BG10606" /db_xref="UniProtKB/Swiss-Prot:P39618" /translation="MKLVLGALQWTAFIIAAAIVVPVAVAQSFHLDHSDSARLIQSTF FVLGIAAVIQCLKGHRLPINESPAGLWWGVYTIYAGLTGTVFATYGDTLRGLQGALLV SAVCFFLLSVFKVIDRLAKLFTPVVTGVYLLLLVMQLSQPIIKGILGIGYRQDGVDGL VFGLALVVIAAAFIMTNSNIMFFKQYSILLALFGGWVLFAAAGAAKPIEMPDRLFQLP SLFPFGTPLFNSGLIITSIFITILLIVNMLASMKVVDIAMKKFSKQPDGKHHERHAGF AASFSHLLSGLTGAIAPVPISGAAGFIETTKMPSKKPFMLGSILVIVISVIPFFMNTF ASLPSPVGFAVNFVVFSAMGGLAFAEFDSYEKEESKRVRSIIGISLLTGVGIMFVPET ALKGLHPVFISLLSNGLVLGTLAAIAADQFQLWRRRKSDNLVSTENKH*" /label="ywdJ CDS" gene complement(3511719..3513041) /gene="ywdJ" /locus_tag="BSU_37940" /old_locus_tag="BSU37940" /label="ywdJ gene" CDS complement(3513061..3513378) /gene="ywdI" /locus_tag="BSU_37950" /old_locus_tag="BSU37950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391674.3" /db_xref="EnsemblGenomes-Gn:BSU37950" /db_xref="EnsemblGenomes-Tr:CAB15821" /db_xref="InterPro:IPR035218" /db_xref="SubtiList:BG10605" /db_xref="UniProtKB/Swiss-Prot:P39617" /translation="MNIHISALIQKMEEELKKAKTAERDEELKRYVAVVRSLCDVVLD QPENASAPRIQPSVTPSPAAPPSTDQLMMEKMMGSAGLNKYRKQEKEKQEEDGNGESL FDF*" /label="ywdI CDS" gene complement(3513061..3513378) /gene="ywdI" /locus_tag="BSU_37950" /old_locus_tag="BSU37950" /label="ywdI gene" promotor_-10 complement(3513407..3513426) /Source="Nicolas_upshift_promotors" /id="U2979" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.517482517482518" /psig=1 /xcortree=1928 /SigmaFactorBS="gcaaggtttgtcagaaaaaataacaaactcatATCTGCGttt tcagcaggaaTTTGATAAAATGCAGGAAGAcaacatttatttttttggagggtgcttc a" /listShort="ywdI, ywdJ, ywdK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3513418) /Source="Nicolas_upshifts" /id="U2979" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.517482517482518" /psig=1 /xcortree=1928 /SigmaFactorBS="gcaaggtttgtcagaaaaaataacaaactcatATCTGCGttt tcagcaggaaTTTGATAAAATGCAGGAAGAcaacatttatttttttggagggtgcttc a" /listShort="ywdI, ywdJ, ywdK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3513440..3513446) /Source="Nicolas_upshift_promotors" /id="U2979" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.517482517482518" /psig=1 /xcortree=1928 /SigmaFactorBS="gcaaggtttgtcagaaaaaataacaaactcatATCTGCGttt tcagcaggaaTTTGATAAAATGCAGGAAGAcaacatttatttttttggagggtgcttc a" /listShort="ywdI, ywdJ, ywdK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3513481..3513488 /Source="Nicolas_upshift_promotors" /id="U2980" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.988011988011988" /xcortree=1868 /SigmaFactorBS="atgagtttgttattttttctgacaaaccttgcgcGATTGACA agcagaagagattttTCACATAATAAATCACCATAccttacaaaaaggagaaacggaa t" /listShort="ywdH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3513504..3513523 /Source="Nicolas_upshift_promotors" /id="U2980" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.988011988011988" /xcortree=1868 /SigmaFactorBS="atgagtttgttattttttctgacaaaccttgcgcGATTGACA agcagaagagattttTCACATAATAAATCACCATAccttacaaaaaggagaaacggaa t" /listShort="ywdH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3513507 /Source="Nicolas_upshifts" /id="U2980" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.988011988011988" /xcortree=1868 /SigmaFactorBS="atgagtttgttattttttctgacaaaccttgcgcGATTGACA agcagaagagattttTCACATAATAAATCACCATAccttacaaaaaggagaaacggaa t" /listShort="ywdH" /GFF_Attribute="listLong" /label="upshifts" CDS 3513546..3514916 /gene="ywdH" /locus_tag="BSU_37960" /old_locus_tag="BSU37960" /EC_number="1.2.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aldehyde dehydrogenase" /protein_id="NP_391675.2" /db_xref="EnsemblGenomes-Gn:BSU37960" /db_xref="EnsemblGenomes-Tr:CAB15822" /db_xref="GOA:P39616" /db_xref="InterPro:IPR012394" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG10604" /db_xref="UniProtKB/Swiss-Prot:P39616" /translation="MNSIPSIISKHKAYFAAGHTRPLESRLNILRKLKQAVRTHEADL IAALYQDLHKSEQEAYSTEIGIVLEEISFVMKRLRKWSKPKRVKTPLTHLGSKSIIIP EPYGTVLVIAPWNYPLQLALSPLIGAIAAGNTVVLKPSEYTPAVSAILSKLISSVFPT DYVAMAEGGPDVSTALLQQPFDYIFFTGSVAVGKIVMEAAAKQLIPVTLELGGKSPCI VHKDADIQLAAKRIVFGKFTNAGQTCIAPDYLFVHEDIKTKLTEEMKRAIREFYGPQP ERNPQYGKIVSERHYQRLLSFLNDGIPLTGGQSDPNHHKIAPTILEQVRDDSPVMQEE IFGPILPLFTYRNIGEVIEKVQSRPKPLALYLFTTNKEIERAVLGNLSFGGGCVNDTL MHVATPYLPFGGVGESGIGSYHGFDSFNTFTHKKSVVKQTNRFDFAFRYPSSKNGLRM IRKILK*" /label="ywdH CDS" gene 3513546..3514916 /gene="ywdH" /locus_tag="BSU_37960" /old_locus_tag="BSU37960" /label="ywdH gene" CDS complement(3514941..3515618) /gene="ung" /locus_tag="BSU_37970" /old_locus_tag="BSU37970" /EC_number="3.2.2.27" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:1902430, 9776748, 10080896, 21542855, 22056936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1902430, 9776748, 10080896, 21542855, 22056936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="uracil-DNA glycosylase" /protein_id="NP_391676.1" /db_xref="EnsemblGenomes-Gn:BSU37970" /db_xref="EnsemblGenomes-Tr:CAB15823" /db_xref="GOA:P39615" /db_xref="InterPro:IPR002043" /db_xref="InterPro:IPR005122" /db_xref="InterPro:IPR018085" /db_xref="InterPro:IPR036895" /db_xref="PDB:3ZOQ" /db_xref="PDB:3ZOR" /db_xref="SubtiList:BG10603" /db_xref="UniProtKB/Swiss-Prot:P39615" /translation="MKQLLQDSWWNQLKEEFEKPYYQELREMLKREYAEQTIYPDSRD IFNALHYTSYDDVKVVILGQDPYHGPGQAQGLSFSVKPGVKQPPSLKNIFLELQQDIG CSIPNHGSLVSWAKQGVLLLNTVLTVRRGQANSHKGKGWERLTDRIIDVLSERERPVI FILWGRHAQMKKERIDTSKHFIIESTHPSPFSARNGFFGSRPFSRANAYLEKMGEAPI DWCIKDL*" /label="ung CDS" gene complement(3514941..3515618) /gene="ung" /locus_tag="BSU_37970" /old_locus_tag="BSU37970" /label="ung gene" downshifts complement(3514955) /Source="Nicolas_upshifts" /id="D1963" /incds=0 /nref=66 /ntot=224 /MaxReadThrough="2.25259" /MaxDrop="4.72154" /score="26.8023311" /energy="-9.1" /TU="NA" /idTUdmin="U2982" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3515445..3515464) /Source="Nicolas_upshift_promotors" /id="U2981" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.425574425574426" /psig="0.837162837162837" /xcortree=1736 /SigmaFactorBS="acgcggagcaaacgatttatccggacagccgggataTTTTCA acgcgctgcattataCATCATATGATGATGTCAAGgtcgtcattttgggtcaagatcc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3515461) /Source="Nicolas_upshifts" /id="U2981" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.425574425574426" /psig="0.837162837162837" /xcortree=1736 /SigmaFactorBS="acgcggagcaaacgatttatccggacagccgggataTTTTCA acgcgctgcattataCATCATATGATGATGTCAAGgtcgtcattttgggtcaagatcc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3515480..3515485) /Source="Nicolas_upshift_promotors" /id="U2981" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.425574425574426" /psig="0.837162837162837" /xcortree=1736 /SigmaFactorBS="acgcggagcaaacgatttatccggacagccgggataTTTTCA acgcgctgcattataCATCATATGATGATGTCAAGgtcgtcattttgggtcaagatcc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3515632..3516438) /gene="ywdF" /locus_tag="BSU_37980" /old_locus_tag="BSU37980" /EC_number="2.4.-.-" /function="16.13: Shape" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9334165; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_391677.1" /db_xref="EnsemblGenomes-Gn:BSU37980" /db_xref="EnsemblGenomes-Tr:CAB15824" /db_xref="GOA:P39614" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10602" /db_xref="UniProtKB/Swiss-Prot:P39614" /translation="MKISIVIVTYNRIPALCELLESISRQTLMPYEIIIVNDAGESVV PVKALYPELPIAVINLEKNSGHVAARNAGVKEASGDCIMLCDDDDFFTPGHIEKMAKE IETADFVHSDAEIVSFEEKNGTRYPVSRKLFAYTADYEDMRVFSTYVPSGSMYRRFLH DEIGYFDADVHNYWDWDFYLRAAKDYRVKRVPCASVIYAFSDAGDNQSADLGAKRKQY LDRLSEKHGLGELPTKNFAVLLEEPEMKRREAKSEMVWDGEPVYSRLHRS*" /label="ywdF CDS" gene complement(3515632..3516438) /gene="ywdF" /locus_tag="BSU_37980" /old_locus_tag="BSU37980" /label="ywdF gene" promotor_-10 complement(3515931..3515949) /Source="Nicolas_upshift_promotors" /id="U2982" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=139 /SigmaFactorBS="tttctacatacgtgccgtcgggcagcatgtacagaCGTTTTC tgcatgatgaaatcGGGTATTTCGATGCTGATGtgcacaattactgggactgggattt t" /listShort="ung" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3515945) /Source="Nicolas_upshifts" /id="U2982" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=139 /SigmaFactorBS="tttctacatacgtgccgtcgggcagcatgtacagaCGTTTTC tgcatgatgaaatcGGGTATTTCGATGCTGATGtgcacaattactgggactgggattt t" /listShort="ung" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3515964..3515970) /Source="Nicolas_upshift_promotors" /id="U2982" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=139 /SigmaFactorBS="tttctacatacgtgccgtcgggcagcatgtacagaCGTTTTC tgcatgatgaaatcGGGTATTTCGATGCTGATGtgcacaattactgggactgggattt t" /listShort="ung" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3516467..3516486) /Source="Nicolas_upshift_promotors" /id="U2983" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.612387612387612" /psig="0.996003996003996" /xcortree=2559 /SigmaFactorBS="ttgtagtatgccgtttcagtaggaTATTCCCActgatctccc gtccaATATATGTTTTAATAGTACAtgactatgaaaatgagaaggagagcatcatgaa g" /listShort="ywdF, ung" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3516473) /Source="Nicolas_upshifts" /id="U2983" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.612387612387612" /psig="0.996003996003996" /xcortree=2559 /SigmaFactorBS="ttgtagtatgccgtttcagtaggaTATTCCCActgatctccc gtccaATATATGTTTTAATAGTACAtgactatgaaaatgagaaggagagcatcatgaa g" /listShort="ywdF, ung" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3516502..3516509) /Source="Nicolas_upshift_promotors" /id="U2983" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.612387612387612" /psig="0.996003996003996" /xcortree=2559 /SigmaFactorBS="ttgtagtatgccgtttcagtaggaTATTCCCActgatctccc gtccaATATATGTTTTAATAGTACAtgactatgaaaatgagaaggagagcatcatgaa g" /listShort="ywdF, ung" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3516528..3517061) /gene="ywdE" /locus_tag="BSU_37990" /old_locus_tag="BSU37990" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein of unknown function" /protein_id="NP_391678.1" /db_xref="EnsemblGenomes-Gn:BSU37990" /db_xref="EnsemblGenomes-Tr:CAB15825" /db_xref="GOA:P39613" /db_xref="SubtiList:BG10601" /db_xref="UniProtKB/Swiss-Prot:P39613" /translation="MRISSCLYGFVAHGAVFLFTGGCMLLAMAASLPFVFLLDRLPDV VFTAGAILTLLCSYAYVWFWAVRFAYNQKMRLFEVQLGSFVLLALMISLFLLDGSSMK DIMMNWDDAGCAFVPPAFTFLCLSYALVLLPVYQSKLWRLILPNGVRMKDIFHVFGDL MLIMVLLIGATLLFLSL*" /label="ywdE CDS" gene complement(3516528..3517061) /gene="ywdE" /locus_tag="BSU_37990" /old_locus_tag="BSU37990" /label="ywdE gene" CDS complement(3517109..3517744) /gene="ywdD" /locus_tag="BSU_38000" /old_locus_tag="BSU38000" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein of unknown function" /protein_id="NP_391679.2" /db_xref="EnsemblGenomes-Gn:BSU38000" /db_xref="EnsemblGenomes-Tr:CAB15826" /db_xref="GOA:P39612" /db_xref="SubtiList:BG10600" /db_xref="UniProtKB/Swiss-Prot:P39612" /translation="MDKETYVSEIKSGLKGLPEGEAMIEEIESHIEHHLFRSFQEGKS EEEAMQTLLQAFGTPTDIVSSFKKIQPVTFRAFLMFHLFCNSALFAVGIAITIMHVWL ESPFVQAVWKGISVSVWLILAAYMIYWVLIGYQGVKEFGKRGEKLVLHTILISMVPNV IFMLVFLFNVIPAALFQSLLTPWFVGTCAFATLLFPLFGRMGCYIGRRQLV*" /label="ywdD CDS" gene complement(3517109..3517744) /gene="ywdD" /locus_tag="BSU_38000" /old_locus_tag="BSU38000" /label="ywdD gene" CDS complement(3517737..3518075) /gene="ywzG" /locus_tag="BSU_38018" /old_locus_tag="BSU38018" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator, PadR family" /protein_id="YP_003097793.1" /db_xref="EnsemblGenomes-Gn:BSU38018" /db_xref="EnsemblGenomes-Tr:CAX52706" /db_xref="GOA:C0H3S6" /db_xref="InterPro:IPR005149" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="UniProtKB/Swiss-Prot:C0H3S6" /translation="MLNRELVKGSTVILVLTLLNERPMYGYELVKEMGSRSGNELQMK EGTLYPSLHKLERQGYISSYWEKQEKGPDRKYYRITDEGKEVLAERTKEWSVFSAMMD RILKWSGQNG*" /label="ywzG CDS" gene complement(3517737..3518075) /gene="ywzG" /locus_tag="BSU_38018" /old_locus_tag="BSU38018" /label="ywzG gene" promotor_-10 complement(3518097..3518116) /Source="Nicolas_upshift_promotors" /id="U2984" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.468531468531469" /psig="0.998001998001998" /xcortree=2997 /SigmaFactorBS="gtatcacaatatagaagatctataggaatcATTTGACAatct caacgggcttTCGTAAAATGCTACATAAGAaaactaggtaggggttttgagatgttaa a" /listShort="ywzG, ywdD, ywdE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3518108) /Source="Nicolas_upshifts" /id="U2984" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.468531468531469" /psig="0.998001998001998" /xcortree=2997 /SigmaFactorBS="gtatcacaatatagaagatctataggaatcATTTGACAatct caacgggcttTCGTAAAATGCTACATAAGAaaactaggtaggggttttgagatgttaa a" /listShort="ywzG, ywdD, ywdE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3518131..3518138) /Source="Nicolas_upshift_promotors" /id="U2984" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.468531468531469" /psig="0.998001998001998" /xcortree=2997 /SigmaFactorBS="gtatcacaatatagaagatctataggaatcATTTGACAatct caacgggcttTCGTAAAATGCTACATAAGAaaactaggtaggggttttgagatgttaa a" /listShort="ywzG, ywdD, ywdE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3518159..3518162 /Source="Nicolas_upshift_promotors" /id="U2985" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2350 /SigmaFactorBS="aagcccgttgagattgtcaaatgattcctatagatcttctat ATTGtgatacagagaaaaTCTAACTATAATGAAAGACAaaacatgatggaggttcaag a" /listShort="pdxK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3518177..3518196 /Source="Nicolas_upshift_promotors" /id="U2985" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2350 /SigmaFactorBS="aagcccgttgagattgtcaaatgattcctatagatcttctat ATTGtgatacagagaaaaTCTAACTATAATGAAAGACAaaacatgatggaggttcaag a" /listShort="pdxK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3518177 /Source="Nicolas_upshifts" /id="U2985" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2350 /SigmaFactorBS="aagcccgttgagattgtcaaatgattcctatagatcttctat ATTGtgatacagagaaaaTCTAACTATAATGAAAGACAaaacatgatggaggttcaag a" /listShort="pdxK" /GFF_Attribute="listLong" /label="upshifts" CDS 3518219..3519034 /gene="pdxK" /locus_tag="BSU_38020" /old_locus_tag="BSU38020" /EC_number="2.7.1.35" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 14973012, 17012797" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 14973012, 17012797; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyridoxine, pyridoxal, and pyridoxamine kinase" /protein_id="NP_391681.1" /db_xref="EnsemblGenomes-Gn:BSU38020" /db_xref="EnsemblGenomes-Tr:CAB15828" /db_xref="GOA:P39610" /db_xref="InterPro:IPR004399" /db_xref="InterPro:IPR013749" /db_xref="InterPro:IPR029056" /db_xref="PDB:2I5B" /db_xref="SubtiList:BG10598" /db_xref="UniProtKB/Swiss-Prot:P39610" /translation="MSMHKALTIAGSDSSGGAGIQADLKTFQEKNVYGMTALTVIVAM DPNNSWNHQVFPIDTDTIRAQLATITDGIGVDAMKTGMLPTVDIIELAAKTIKEKQLK NVVIDPVMVCKGANEVLYPEHAQALREQLAPLATVITPNLFEASQLSGMDELKTVDDM IEAAKKIHALGAQYVVITGGGKLKHEKAVDVLYDGETAEVLESEMIDTPYTHGAGCTF SAAVTAELAKGAEVKEAIYAAKEFITAAIKESFPLNQYVGPTKHSALRLNQQS*" /label="pdxK CDS" gene 3518219..3519034 /gene="pdxK" /locus_tag="BSU_38020" /old_locus_tag="BSU38020" /label="pdxK gene" downshifts 3519013 /Source="Nicolas_upshifts" /id="D1964" /incds=0 /nref=185 /ntot=251 /MaxReadThrough="2.56759" /MaxDrop="5.39956" /score="22.0760698" /energy="-18.1" /TU="NA" /idTUdmin="U2985" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(3519089) /Source="Nicolas_upshifts" /id="D1965" /incds=0 /nref=20 /ntot=111 /MaxReadThrough="0.56945" /MaxDrop="6.81686" /score="39.7901804" /energy="-16.8" /TU="NA" /idTUdmin="U2987" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3519124..3519372) /gene="ywdA" /locus_tag="BSU_38030" /old_locus_tag="BSU38030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391682.1" /db_xref="EnsemblGenomes-Gn:BSU38030" /db_xref="EnsemblGenomes-Tr:CAB15829" /db_xref="SubtiList:BG10597" /db_xref="UniProtKB/Swiss-Prot:P39609" /translation="MNIHEQKITPECLEKAANQVEDKREEYKDVLLQLKKMLGGTTPH SETAEILTRAYEQMKEYALFVQSIETFLRKSANNLKIK*" /label="ywdA CDS" gene complement(3519124..3519372) /gene="ywdA" /locus_tag="BSU_38030" /old_locus_tag="BSU38030" /label="ywdA gene" downshifts complement(3519144) /Source="Nicolas_upshifts" /id="D1966" /incds=0 /nref=6 /ntot=123 /MaxReadThrough="6.75845" /MaxDrop="3.89221" /score="22.6408081" /energy="-10.8" /TU="U2987,U2988" /idTUdmin="U2986" /TUdmin=11 /isTUend="TRUE" /label="downshifts" upshifts complement(3519390) /Source="Nicolas_upshifts" /id="U2986" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.211788211788212" /psig="0.230769230769231" /xcortree=577 /SigmaFactorBS="tcttatgtgaaatctgagccatctgtgctattcttcaacgat aaCCTACTAtttttttctgtaaaaggagttgttttcttgaatatacatgaacagaaga t" /listShort="ywdA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3519392..3519465) /Source="Nicolas_S_feature" /locus_tag="new_3902136_3902209_c" /HighExp="G150, Mt0, Diami, Lbexp, dia0, dia5, T0.30H, Oxctl, Etha, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.536, 0.743, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1464" misc_feature complement(3519400..3519406) /Source="Nicolas_upshift_promotors" /id="U2986" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.211788211788212" /psig="0.230769230769231" /xcortree=577 /SigmaFactorBS="tcttatgtgaaatctgagccatctgtgctattcttcaacgat aaCCTACTAtttttttctgtaaaaggagttgttttcttgaatatacatgaacagaaga t" /listShort="ywdA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(3519466..3520905) /gene="sacA" /locus_tag="BSU_38040" /old_locus_tag="BSU38040" /EC_number="3.2.1.26" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 3100393; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sucrose-6-phosphate hydrolase" /protein_id="NP_391683.2" /db_xref="EnsemblGenomes-Gn:BSU38040" /db_xref="EnsemblGenomes-Tr:CAB15830" /db_xref="GOA:P07819" /db_xref="InterPro:IPR001362" /db_xref="InterPro:IPR006232" /db_xref="InterPro:IPR013148" /db_xref="InterPro:IPR013189" /db_xref="InterPro:IPR013320" /db_xref="InterPro:IPR018053" /db_xref="InterPro:IPR023296" /db_xref="SubtiList:BG10596" /db_xref="UniProtKB/Swiss-Prot:P07819" /translation="MTAHDQELRRRAYEEVEKKEPIANSDPHRQHFHIMPPVGLLNDP NGVIYWKGSYHVFFQWQPFQTGHGAKFWGHYTTQDVVNWKREEIALAPSDWFDKNGCY SGSAVTKDDRLYLFYTGNVRDQDGNRETYQCLAVSDDGLSFEKKGVVARLPEGYTAHF RDPKVWEHEGTWYMVIGAQTENLKGQAVLFASDNLTEWRFLGPITGAGFNGLDDFGYM WECPDLFSLQGSDVLIVSPQGLEADGFRYQNVYQSGYFVGRLDYNKPELKHGEFTELD QGFDFYAPQTLEDDQGRRILFAWMAVPDQDEGSHPTIDCHWIHCMTLPRQLTLSGQKL IQQPLPELKAMRRNEKKIHINMHGSSGALPVEKPERTEILLEDIHTESGFSISIRGTA TFSFHKDEGIVTLERKSFDGKRTEARHCRIKDLHTVHMFLDASSVEIFINNGEEVLSA RYFPFPGNHEVTASATGKSEMNVGIWTLM*" /label="sacA CDS" gene complement(3519466..3520905) /gene="sacA" /locus_tag="BSU_38040" /old_locus_tag="BSU38040" /label="sacA gene" CDS complement(3520902..3522287) /gene="sacP" /locus_tag="BSU_38050" /old_locus_tag="BSU38050" /EC_number="2.7.1.211" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1577686, 3122206, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1577686, 3122206, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) sucrose-specificenzyme IIBC component" /protein_id="NP_391684.3" /db_xref="EnsemblGenomes-Gn:BSU38050" /db_xref="EnsemblGenomes-Tr:CAB15831" /db_xref="GOA:P05306" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR004719" /db_xref="InterPro:IPR010973" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG10595" /db_xref="UniProtKB/Swiss-Prot:P05306" /translation="MDYKETAKRLIELLGGKENIISAAHCATRLRLVMKDESKIDQAQ VEELDGVKGAFSSSGQYQIIFGTGLVNKVFDAFSKEADIEREEHVNHQDAAKEKLNPA ARFAKTLSNIFVPIIPAIVASGLLMGLLGMINAFHWMSKDSALLQLLDMFSSAAFIFL PILIGVSASKEFGSNPYLGAVIGGIMIHPNLLNPWGLAEATPDYMHLFGFDIALLGYQ GTVIPVLLAVYVMSKVEKWTRKVVPHAVDLLVTPFVTVIVTGFVAFIAIGPLGRALGS GITVALTYVYDHAGFVAGLIFGGTYSLIVLTGVHHSFHAIEAGLIADIGKNYLLPIWS MANVAQGGAGLAVFFMAKKAKTKEIALPAAFSAFLGITEPVIFGVNLRYRKPFIAAMI GGALGGAYVVFTHVAANAYGLTGIPMIAIAAPFGFSNLIHYLIGMAIAAVSAFIAAFV MKINEDEERKK*" /label="sacP CDS" gene complement(3520902..3522287) /gene="sacP" /locus_tag="BSU_38050" /old_locus_tag="BSU38050" /label="sacP gene" misc_feature complement(3522306..3522315) /Source="Nicolas_upshift_promotors" /id="U2987" /multdbtbs="-" /comp="M21" /sig="SigA" /pcomp="0.258741258741259" /psig="0.536463536463537" /xcortree=1560 /SigmaFactorBS="ctaaaatttgcgtaaatgaaaaaggatcgctgtgtcctttat tcgttggcgaattttaggtctttTTTGTTTAAAtaaaagggggagaaatagatggatt a" /listShort="sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3522320) /Source="Nicolas_upshifts" /id="U2987" /multdbtbs="-" /comp="M21" /sig="SigA" /pcomp="0.258741258741259" /psig="0.536463536463537" /xcortree=1560 /SigmaFactorBS="ctaaaatttgcgtaaatgaaaaaggatcgctgtgtcctttat tcgttggcgaattttaggtctttTTTGTTTAAAtaaaagggggagaaatagatggatt a" /listShort="sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3522322..3522386) /Source="Nicolas_S_feature" /locus_tag="new_3905066_3905130_c" /HighExp="Diami, G150, dia5, Mt0, M9-stat, Lbtran, Gly, dia0, Oxctl, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.743, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1465" promotor_-10 complement(3522365..3522382) /Source="Nicolas_upshift_promotors" /id="U2988" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.538461538461538" /psig="0.743256743256743" /xcortree=1561 /SigmaFactorBS="gatttatgatgaaagcgtattcttaatctgaataagcgggaT TGTGACTggtaaagcaggcaagACCTAAAATTTGCGTAAAtgaaaaaggatcgctgtg t" /listShort="S1465, sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3522386) /Source="Nicolas_upshifts" /id="U2988" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.538461538461538" /psig="0.743256743256743" /xcortree=1561 /SigmaFactorBS="gatttatgatgaaagcgtattcttaatctgaataagcgggaT TGTGACTggtaaagcaggcaagACCTAAAATTTGCGTAAAtgaaaaaggatcgctgtg t" /listShort="S1465, sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3522398..3522405) /Source="Nicolas_upshift_promotors" /id="U2988" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.538461538461538" /psig="0.743256743256743" /xcortree=1561 /SigmaFactorBS="gatttatgatgaaagcgtattcttaatctgaataagcgggaT TGTGACTggtaaagcaggcaagACCTAAAATTTGCGTAAAtgaaaaaggatcgctgtg t" /listShort="S1465, sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3522428..3522447) /Source="Nicolas_upshift_promotors" /id="U2989" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1544 /SigmaFactorBS="ttgtctacatgttatatcaaactatttaactaaaaaaaTAGT TGACgaaaacgctatcaTGATTTATGATGAAAGCGTAttcttaatctgaataagcggg a" /listShort="S1465, sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3522446) /Source="Nicolas_upshifts" /id="U2989" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1544 /SigmaFactorBS="ttgtctacatgttatatcaaactatttaactaaaaaaaTAGT TGACgaaaacgctatcaTGATTTATGATGAAAGCGTAttcttaatctgaataagcggg a" /listShort="S1465, sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3522461..3522468) /Source="Nicolas_upshift_promotors" /id="U2989" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1544 /SigmaFactorBS="ttgtctacatgttatatcaaactatttaactaaaaaaaTAGT TGACgaaaacgctatcaTGATTTATGATGAAAGCGTAttcttaatctgaataagcggg a" /listShort="S1465, sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3522527..3522530 /Source="Nicolas_upshift_promotors" /id="U2990" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.676323676323676" /psig="0.997002997002997" /xcortree=1600 /SigmaFactorBS="gttaaatagtttgatataacatgtagacaaaaattcgtaaaa attaattgTGAAatacttcacaatatCGTGCTATACTATGCTCAATcatgaaagaaag c" /listShort="ywcJ, S1466" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3522537 /Source="Nicolas_upshifts" /id="U2990" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.676323676323676" /psig="0.997002997002997" /xcortree=1600 /SigmaFactorBS="gttaaatagtttgatataacatgtagacaaaaattcgtaaaa attaattgTGAAatacttcacaatatCGTGCTATACTATGCTCAATcatgaaagaaag c" /listShort="ywcJ, S1466" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3522545..3522564 /Source="Nicolas_upshift_promotors" /id="U2990" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.676323676323676" /psig="0.997002997002997" /xcortree=1600 /SigmaFactorBS="gttaaatagtttgatataacatgtagacaaaaattcgtaaaa attaattgTGAAatacttcacaatatCGTGCTATACTATGCTCAATcatgaaagaaag c" /listShort="ywcJ, S1466" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3522589..3523359 /gene="nirC" /locus_tag="BSU_38060" /old_locus_tag="BSU38060" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16207915, 16428414, 16850406, 18691156; Product type t : transporter" /codon_start=1 /transl_table=11 /product="nitrite transporter" /protein_id="NP_391685.1" /db_xref="EnsemblGenomes-Gn:BSU38060" /db_xref="EnsemblGenomes-Tr:CAB15832" /db_xref="GOA:P39608" /db_xref="InterPro:IPR000292" /db_xref="InterPro:IPR023271" /db_xref="InterPro:IPR024002" /db_xref="SubtiList:BG10594" /db_xref="UniProtKB/Swiss-Prot:P39608" /translation="METQALQKVEQYALKKQNIFASSKIRYVLRSILASIFIGFGITA ASKTGSYFFMADSPFAFPAAAVTFGAAILMIAYGGGDLFTGNTFYFTYTALRKKISWR DTLYLWMSSYAGNLIGAILFAILISATGLFEEPSVHSFLIHLAEHKMEPPASELFFRG MLCNWLVCLAFFIPMSLKGEGAKLFTMMLFVFCFFISGFEHSIANMCTFAISLLIEHP DTVTLMGAVRNLIPVTLGNLTAGIVMMGWMYYTLNPDQ*" /label="nirC CDS" gene 3522589..3523359 /gene="nirC" /locus_tag="BSU_38060" /old_locus_tag="BSU38060" /label="nirC gene" S_feature 3523360..3524427 /Source="Nicolas_S_feature" /locus_tag="new_3906104_3907171" /HighExp="S0, ferm, M0t45, Lbexp, Mal, dia0, M/G, UNK1, M40t45, BI" /AntisenseName="sacT" /AntisenseCor="-0.34218080984654098" /AntisenseRegPval="-8.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1466" CDS complement(3523398..3524228) /gene="sacT" /locus_tag="BSU_38070" /old_locus_tag="BSU38070" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1577686, 2163394, 8535520, 8702561, 19202299, 21278164" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1577686, 2163394, 8535520, 8702561, 19202299, 21278164; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional antiterminator of sacAP expression" /protein_id="NP_391686.1" /db_xref="EnsemblGenomes-Gn:BSU38070" /db_xref="EnsemblGenomes-Tr:CAB15833" /db_xref="GOA:P26212" /db_xref="InterPro:IPR001550" /db_xref="InterPro:IPR004341" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR036634" /db_xref="InterPro:IPR036650" /db_xref="SubtiList:BG10593" /db_xref="UniProtKB/Swiss-Prot:P26212" /translation="MKIYKVLNNNAALIKEDDQEKIVMGPGIAFQKKKNDLIPMNKVE KIFVVRDENEKFKQILQTLPEEHIEIAEDIISYAEGELAAPLSDHIHIALSDHLSFAI ERIQNGLLVQNKLLHEIKALYKKEYEIGLWAIGHVKETLGVSLPEDEAGYIALHIHTA KMDAESMYSALKHTTMIKEMIEKIKQYFNRKVDENSISYQRLVTHLRYAVSRLESNEA LHRMDEEMLYFIQKKYSFAYQCALELAEFLKNEYQLHLPESEAGYITLHVQRLQDLSE *" /label="sacT CDS" gene complement(3523398..3524228) /gene="sacT" /locus_tag="BSU_38070" /old_locus_tag="BSU38070" /label="sacT gene" downshifts complement(3523399) /Source="Nicolas_upshifts" /id="D1967" /incds=0 /nref=49 /ntot=139 /MaxReadThrough="3.34691" /MaxDrop="4.9787" /score="11.2756812" /energy="-8.1" /TU="U2992" /idTUdmin="U2991" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3524254..3524273) /Source="Nicolas_upshift_promotors" /id="U2991" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.72027972027972" /psig="0.943056943056943" /xcortree=452 /SigmaFactorBS="caaagcaggagagagcgggcccgcaTCTTTACAtggcggtca aaaggAGGTAAAATCCCAGTCAAAAgcaaattggcgggagagataacctcttgaaaat c" /listShort="sacT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3524260) /Source="Nicolas_upshifts" /id="U2991" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.72027972027972" /psig="0.943056943056943" /xcortree=452 /SigmaFactorBS="caaagcaggagagagcgggcccgcaTCTTTACAtggcggtca aaaggAGGTAAAATCCCAGTCAAAAgcaaattggcgggagagataacctcttgaaaat c" /listShort="sacT" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3524268..3524570) /gene="ywcI" /locus_tag="BSU_38080" /old_locus_tag="BSU38080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391687.2" /db_xref="EnsemblGenomes-Gn:BSU38080" /db_xref="EnsemblGenomes-Tr:CAB15834" /db_xref="SubtiList:BG10592" /db_xref="UniProtKB/Swiss-Prot:P39607" /translation="MKRLLVSLRVWMVFLMNWVTPDRKTAAAAVYSAQRTYQRKAAVQ AAGLVSFYEWRMAVNEEEKQKAKAAALYKRRCLQAFKESPKQERAGPHLYMAVKRR*" /label="ywcI CDS" gene complement(3524268..3524570) /gene="ywcI" /locus_tag="BSU_38080" /old_locus_tag="BSU38080" /label="ywcI gene" promotor_-35 complement(3524288..3524295) /Source="Nicolas_upshift_promotors" /id="U2991" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.72027972027972" /psig="0.943056943056943" /xcortree=452 /SigmaFactorBS="caaagcaggagagagcgggcccgcaTCTTTACAtggcggtca aaaggAGGTAAAATCCCAGTCAAAAgcaaattggcgggagagataacctcttgaaaat c" /listShort="sacT" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3524571..3524709) /Source="Nicolas_S_feature" /locus_tag="new_3907315_3907453_c" /HighExp="T5.0H, M9-stat, S2, S4, T4.0H, S3, T3.30H, LoTm, B36, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.823" /TUlongSig="NA" /TUlongPSig="NA" /label="S1467" misc_feature complement(3524694..3524713) /Source="Nicolas_upshift_promotors" /id="U2992" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.388611388611389" /psig="0.823176823176823" /xcortree=968 /SigmaFactorBS="cttctaaaaactagttggttttttcactcatattgtgacaaa gaattctctttccaCGGTCTATCATAGAGTCATGagttttgctagagccgctagtttg c" /listShort="S1467, ywcI, sacT" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3524709) /Source="Nicolas_upshifts" /id="U2992" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.388611388611389" /psig="0.823176823176823" /xcortree=968 /SigmaFactorBS="cttctaaaaactagttggttttttcactcatattgtgacaaa gaattctctttccaCGGTCTATCATAGAGTCATGagttttgctagagccgctagtttg c" /listShort="S1467, ywcI, sacT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3525024..3525032 /Source="Nicolas_upshift_promotors" /id="U2993" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=466 /SigmaFactorBS="gttatacacaaacaaaatccaataaatggtccaaatgacaCA AGGATTTttttgaatttTCAAGAAATATATACTAGAtctttcacattttttctaaata c" /listShort="vpr" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3525043..3525061 /Source="Nicolas_upshift_promotors" /id="U2993" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=466 /SigmaFactorBS="gttatacacaaacaaaatccaataaatggtccaaatgacaCA AGGATTTttttgaatttTCAAGAAATATATACTAGAtctttcacattttttctaaata c" /listShort="vpr" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3525044 /Source="Nicolas_upshifts" /id="U2993" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=466 /SigmaFactorBS="gttatacacaaacaaaatccaataaatggtccaaatgacaCA AGGATTTttttgaatttTCAAGAAATATATACTAGAtctttcacattttttctaaata c" /listShort="vpr" /GFF_Attribute="listLong" /label="upshifts" CDS 3525100..3527520 /gene="vpr" /locus_tag="BSU_38090" /old_locus_tag="BSU38090" /EC_number="3.4.21.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15205417, 15596354, 16946274, 17666034, 18689487, 25666135" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15205417, 15596354, 16946274, 17666034, 18689487, 25666135; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="extracellular serine protease" /protein_id="NP_391688.1" /db_xref="EnsemblGenomes-Gn:BSU38090" /db_xref="EnsemblGenomes-Tr:CAB15835" /db_xref="GOA:P29141" /db_xref="InterPro:IPR000209" /db_xref="InterPro:IPR003137" /db_xref="InterPro:IPR010259" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR015500" /db_xref="InterPro:IPR022398" /db_xref="InterPro:IPR023827" /db_xref="InterPro:IPR023828" /db_xref="InterPro:IPR025965" /db_xref="InterPro:IPR034213" /db_xref="InterPro:IPR036852" /db_xref="InterPro:IPR037045" /db_xref="SubtiList:BG10591" /db_xref="UniProtKB/Swiss-Prot:P29141" /translation="MKKGIIRFLLVSFVLFFALSTGITGVQAAPASSKTSADLEKAEV FGDIDMTTSKKTTVIVELKEKSLAEAKEAGESQSKSKLKTARTKAKNKAIKAVKNGKV NREYEQVFSGFSMKLPANEIPKLLAVKDVKAVYPNVTYKTDNMKDKDVTISEDAVSPQ MDDSAPYIGANDAWDLGYTGKGIKVAIIDTGVEYNHPDLKKNFGQYKGYDFVDNDYDP KETPTGDPRGEATDHGTHVAGTVAANGTIKGVAPDATLLAYRVLGPGGSGTTENVIAG VERAVQDGADVMNLSLGNSLNNPDWATSTALDWAMSEGVVAVTSNGNSGPNGWTVGSP GTSREAISVGATQLPLNEYAVTFGSYSSAKVMGYNKEDDVKALNNKEVELVEAGIGEA KDFEGKDLTGKVAVVKRGSIAFVDKADNAKKAGAIGMVVYNNLSGEIEANVPGMSVPT IKLSLEDGEKLVSALKAGETKTTFKLTVSKALGEQVADFSSRGPVMDTWMIKPDISAP GVNIVSTIPTHDPDHPYGYGSKQGTSMASPHIAGAVAVIKQAKPKWSVEQIKAAIMNT AVTLKDSDGEVYPHNAQGAGSARIMNAIKADSLVSPGSYSYGTFLKENGNETKNETFT IENQSSIRKSYTLEYSFNGSGISTSGTSRVVIPAHQTGKATAKVKVNTKKTKAGTYEG TVIVREGGKTVAKVPTLLIVKEPDYPRVTSVSVSEGSVQGTYQIETYLPAGAEELAFL VYDSNLDFAGQAGIYKNQDKGYQYFDWDGTINGGTKLPAGEYYLLAYAANKGKSSQVL TEEPFTVE*" /label="vpr CDS" gene 3525100..3527520 /gene="vpr" /locus_tag="BSU_38090" /old_locus_tag="BSU38090" /label="vpr gene" upshifts 3525258 /Source="Nicolas_upshifts" /id="U2994" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.677322677322677" /psig="0.986013986013986" /xcortree=625 /SigmaFactorBS="aaaaacgtcggctgatctggaaaaagccgaggtattcggtga tatcgatatgacgacaagcaaaaaaacAACCGTTATAGTGGAATTAAaagaaaaatcc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 3525267..3525286 /Source="Nicolas_upshift_promotors" /id="U2994" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.677322677322677" /psig="0.986013986013986" /xcortree=625 /SigmaFactorBS="aaaaacgtcggctgatctggaaaaagccgaggtattcggtga tatcgatatgacgacaagcaaaaaaacAACCGTTATAGTGGAATTAAaagaaaaatcc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" downshifts 3527508 /Source="Nicolas_upshifts" /id="D1968" /incds=0 /nref=7 /ntot=104 /MaxReadThrough="0.60305" /MaxDrop="5.33856" /score="26.8487936" /energy="-16.5" /TU="NA" /idTUdmin="U2993" /TUdmin=6 /isTUend="TRUE" /label="downshifts" CDS complement(3527558..3528559) /gene="ywcH" /locus_tag="BSU_38100" /old_locus_tag="BSU38100" /EC_number="1.14.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10913069, 15774866; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative monooxygenase" /protein_id="NP_391689.1" /db_xref="EnsemblGenomes-Gn:BSU38100" /db_xref="EnsemblGenomes-Tr:CAB15836" /db_xref="GOA:P39606" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR019949" /db_xref="InterPro:IPR036661" /db_xref="SubtiList:BG10590" /db_xref="UniProtKB/Swiss-Prot:P39606" /translation="MVSLSILDQSPVSEGSNAETALQQTVALAQAAEDLGYKRFWVSE HHFSKRLAGSSPEVLISHIAAKTKRIRVGSGGVMLPHYSAYKVAENFRVLEGLTPGRI DLGLGRAPGGMPIASWALNDGGKRNADQYPQQIKELTMYLHDLADDKHRFPNLTAAPH ISTAPDVWLLGSSGESALLAAESGAGYMFAHFINGEGGEGTVRQYKRRFKPSVLGDTP RAAVAVFVLCADTEEKAEELGAVLDFTLLAGEQGIPLEGVPSYEAVRKNTYSPYEQRR IADNRNRMIVGTKEQVKERLLALSNAYETEEIMVVTITHHFEDKLRSYRLLQEAFAD* " /label="ywcH CDS" gene complement(3527558..3528559) /gene="ywcH" /locus_tag="BSU_38100" /old_locus_tag="BSU38100" /label="ywcH gene" S_feature complement(3528560..3528721) /Source="Nicolas_S_feature" /locus_tag="new_3911304_3911465_c" /HighExp="Etha, Diami, dia15, LPhT, dia5, H2O2, B60, LBGstat, M9-stat, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigWXY" /TUlongPSig=1 /label="S1468" CDS complement(3528733..3529482) /gene="nfrAA" /locus_tag="BSU_38110" /old_locus_tag="BSU38110" /EC_number="1.5.1.38" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9535080, 9836433, 10913069, 15774866, 20727352, 20862523, 24847778, 25288929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9535080, 9836433, 10913069, 15774866, 20727352, 20862523, 24847778, 25288929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="FMN-containing NADPH-linked nitro/flavin reductase" /protein_id="NP_391690.1" /db_xref="EnsemblGenomes-Gn:BSU38110" /db_xref="EnsemblGenomes-Tr:CAB15837" /db_xref="GOA:P39605" /db_xref="InterPro:IPR000415" /db_xref="InterPro:IPR016446" /db_xref="InterPro:IPR029479" /db_xref="PDB:3N2S" /db_xref="SubtiList:BG10589" /db_xref="UniProtKB/Swiss-Prot:P39605" /translation="MNNTIETILNHRSIRSFTDQLLTAEEIDTLVKSAQAASTSSYVQ AYSIIGVSDPEKKRELSVLAGNQPYVEKNGHFFVFCADLYRHQQLAEEKGEHISELLE NTEMFMVSLIDAALAAQNMSIAAESMGLGICYIGGIRNELDKVTEVLQTPDHVLPLFG LAVGHPANLSGKKPRLPKQAVYHENTYNVNTDDFRHTMNTYDKTISDYYRERTNGKRE ETWSDQILNFMKQKPRTYLNDYVKEKGFNKN*" /label="nfrAA CDS" gene complement(3528733..3529482) /gene="nfrAA" /locus_tag="BSU_38110" /old_locus_tag="BSU38110" /label="nfrAA gene" downshifts complement(3528766) /Source="Nicolas_upshifts" /id="D1969" /incds=0 /nref=11 /ntot=191 /MaxReadThrough="5.92216" /MaxDrop="3.39651" /score="17.7447455" /energy="-9.9" /TU="U2995" /idTUdmin="U2996" /TUdmin=770 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3529500..3529519) /Source="Nicolas_upshift_promotors" /id="U2995" /multdbtbs="SigA,SigD" /comp="M7" /sig="SigA" /pcomp="0.792207792207792" /psig=1 /xcortree=2037 /SigmaFactorBS="gcctttacagaggctgtctttttttgtgcagagcatttcaCT TTtgagatcactttttTTCGGATATGATAAAAAGTGataaggaggtttttgtgatgaa t" /listShort="nfrA, S1468, ywcH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3529517) /Source="Nicolas_upshifts" /id="U2995" /multdbtbs="SigA,SigD" /comp="M7" /sig="SigA" /pcomp="0.792207792207792" /psig=1 /xcortree=2037 /SigmaFactorBS="gcctttacagaggctgtctttttttgtgcagagcatttcaCT TTtgagatcactttttTTCGGATATGATAAAAAGTGataaggaggtttttgtgatgaa t" /listShort="nfrA, S1468, ywcH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3529534..3529537) /Source="Nicolas_upshift_promotors" /id="U2995" /multdbtbs="SigA,SigD" /comp="M7" /sig="SigA" /pcomp="0.792207792207792" /psig=1 /xcortree=2037 /SigmaFactorBS="gcctttacagaggctgtctttttttgtgcagagcatttcaCT TTtgagatcactttttTTCGGATATGATAAAAAGTGataaggaggtttttgtgatgaa t" /listShort="nfrA, S1468, ywcH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3529588..3530769) /gene="rodA" /locus_tag="BSU_38120" /old_locus_tag="BSU38120" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9622350, 15612918, 15849754, 16850406, 28085152" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9622350, 15612918, 15849754, 16850406, 28085152; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycosyltransferase involved in extension of thelateral walls of the cell" /protein_id="NP_391691.1" /db_xref="EnsemblGenomes-Gn:BSU38120" /db_xref="EnsemblGenomes-Tr:CAB15838" /db_xref="GOA:P39604" /db_xref="InterPro:IPR001182" /db_xref="InterPro:IPR018365" /db_xref="SubtiList:BG10588" /db_xref="UniProtKB/Swiss-Prot:P39604" /translation="MSRYKKQQSPFYQGDLIFIFGVFFIISVVSIYAAGQFGQYGNTD WIQQIVFYLLGAVAITVLLYFDLEQLEKLSLYIFIIGILSLIILKISPESIAPVIKGA KSWFRIGRITIQPSEFMKVGLIMMLASVIGKANPKGVRTLRDDIHLLLKIAGVAVIPV GLILMQDAGTAGICMFIVLVMVFMSGINWKLIAIIAGSGILLISLILLVMINFPDVAK SVGIQDYQIKRVTSWVSASNETQEDSNDSWQVDQAIMAIGSGGILGNGISNLKVYVPE STTDFIFSIIGESFGFIGCAIVVIMFFFLIYRLVVLIDKIHPFNRFASFFCVGYTALI VIHTFQNIGMNIGIMPVTGIPLLFVSYGGSSTLSTLIGFGIVYNASVQLTKYRSYLFN S*" /label="rodA CDS" gene complement(3529588..3530769) /gene="rodA" /locus_tag="BSU_38120" /old_locus_tag="BSU38120" /label="rodA gene" downshifts complement(3529602) /Source="Nicolas_upshifts" /id="D1970" /incds=0 /nref=20 /ntot=124 /MaxReadThrough="3.38052" /MaxDrop="5.67563" /score="31.4805549" /energy="-13.3" /TU="U2996" /idTUdmin="U2996" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" S_feature complement(3530770..3530901) /Source="Nicolas_S_feature" /locus_tag="new_3913514_3913645_c" /HighExp="Heat, T0.30H, H2O2, T1.0H, Salt, Paraq, T1.30H, LBGstat, Oxctl, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1469" promotor_-10 complement(3530895..3530910) /Source="Nicolas_upshift_promotors" /id="U2996" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1657 /SigmaFactorBS="tttttttcatttgaaaagttttgtgtcaatCGAAACATTTcg gtttatgatACGTCATATTTCGTGTagctgaaaaagcgccgcaaatgctgaaaaaaca t" /listShort="S1469, rodA" /listLong="nfrA, S1468, ywcH" /label="promotor_-10" upshifts complement(3530901) /Source="Nicolas_upshifts" /id="U2996" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1657 /SigmaFactorBS="tttttttcatttgaaaagttttgtgtcaatCGAAACATTTcg gtttatgatACGTCATATTTCGTGTagctgaaaaagcgccgcaaatgctgaaaaaaca t" /listShort="S1469, rodA" /listLong="nfrA, S1468, ywcH" /label="upshifts" promotor_-35 complement(3530922..3530931) /Source="Nicolas_upshift_promotors" /id="U2996" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1657 /SigmaFactorBS="tttttttcatttgaaaagttttgtgtcaatCGAAACATTTcg gtttatgatACGTCATATTTCGTGTagctgaaaaagcgccgcaaatgctgaaaaaaca t" /listShort="S1469, rodA" /listLong="nfrA, S1468, ywcH" /label="promotor_-35" promotor_-35 3531136..3531143 /Source="Nicolas_upshift_promotors" /id="U2997" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=437 /SigmaFactorBS="aaaaaataagacgatagatccagtccatttctgcaaaaacac GTATCAATttctggaaaaCATGGTATAATAATTGTAACagaatgttcaaaaaacaatc a" /listShort="S1470, ywcE" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3531154..3531264 /Source="Nicolas_S_feature" /locus_tag="new_3913898_3914008" /HighExp="M9-stat, T0.30H, T1.30H, T1.0H, T4.0H, T2.30H, T3.30H, T3.0H, T5.0H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1470" promotor_-10 3531154..3531173 /Source="Nicolas_upshift_promotors" /id="U2997" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=437 /SigmaFactorBS="aaaaaataagacgatagatccagtccatttctgcaaaaacac GTATCAATttctggaaaaCATGGTATAATAATTGTAACagaatgttcaaaaaacaatc a" /listShort="S1470, ywcE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3531154 /Source="Nicolas_upshifts" /id="U2997" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=437 /SigmaFactorBS="aaaaaataagacgatagatccagtccatttctgcaaaaacac GTATCAATttctggaaaaCATGGTATAATAATTGTAACagaatgttcaaaaaacaatc a" /listShort="S1470, ywcE" /GFF_Attribute="listLong" /label="upshifts" CDS 3531265..3531528 /gene="ywcE" /locus_tag="BSU_38130" /old_locus_tag="BSU38130" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16159778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16159778; Product type f: factor" /codon_start=1 /transl_table=11 /product="holin-like protein required for proper spore morphogenesis and germination" /protein_id="NP_391692.1" /db_xref="EnsemblGenomes-Gn:BSU38130" /db_xref="EnsemblGenomes-Tr:CAB15839" /db_xref="GOA:P39603" /db_xref="InterPro:IPR020185" /db_xref="SubtiList:BG10587" /db_xref="UniProtKB/Swiss-Prot:P39603" /translation="MMDMFFAYLLVASATPLFIWLDNKKVALSAIPPIILMWVFFFFY ATESLSPLGHTLMIILFAVNVIVAHIAAFIIYGLPYLRRKRSS*" /label="ywcE CDS" gene 3531265..3531528 /gene="ywcE" /locus_tag="BSU_38130" /old_locus_tag="BSU38130" /label="ywcE gene" downshifts 3531418 /Source="Nicolas_upshifts" /id="D1971" /incds=1 /nref=1 /ntot=99 /MaxReadThrough="6.85004" /MaxDrop="2.5697" /score="27.9247684" /energy="-11.4" /TU="U2997" /idTUdmin="U2997" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" downshifts 3531534 /Source="Nicolas_upshifts" /id="D1972" /incds=0 /nref=7 /ntot=90 /MaxReadThrough="2.04756" /MaxDrop="6.52141" /score="27.9247684" /energy="-11.4" /TU="NA" /idTUdmin="U2997" /TUdmin=6 /isTUend="TRUE" /label="downshifts" CDS complement(3531571..3531945) /gene="qoxD" /locus_tag="BSU_38140" /old_locus_tag="BSU38140" /EC_number="1.10.3.12" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1316894, 7495838, 7575098, 10551842, 15849754, 16850406, 26196462" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1316894, 7495838, 7575098, 10551842, 15849754, 16850406, 26196462; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome aa3-600 quinol oxidase (subunit IV)" /protein_id="NP_391693.1" /db_xref="EnsemblGenomes-Gn:BSU38140" /db_xref="EnsemblGenomes-Tr:CAB15840" /db_xref="GOA:P34959" /db_xref="InterPro:IPR005171" /db_xref="InterPro:IPR014250" /db_xref="SubtiList:BG10586" /db_xref="UniProtKB/Swiss-Prot:P34959" /translation="MANKSAEHSHFPWKHIVGFILSIVLTLLALWVAVYTDLSSSAKL WIIFGFAFIQAALQLLMFMHMTESENGTIQVGNTLFGFFGAIVIVLGSIWIFAAHYHH GDHMDGNPPGGAEHSEHSGHNE*" /label="qoxD CDS" gene complement(3531571..3531945) /gene="qoxD" /locus_tag="BSU_38140" /old_locus_tag="BSU38140" /label="qoxD gene" downshifts complement(3531582) /Source="Nicolas_upshifts" /id="D1973" /incds=0 /nref=222 /ntot=267 /MaxReadThrough="2.42368" /MaxDrop="9.0593" /score="21.3154492" /energy="-11.4" /TU="NA" /idTUdmin="U3000" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3531947..3532561) /gene="qoxC" /locus_tag="BSU_38150" /old_locus_tag="BSU38150" /EC_number="1.10.3.12" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1316894, 7495838, 7575098, 10551842, 15849754, 16850406, 26196462" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1316894, 7495838, 7575098, 10551842, 15849754, 16850406, 26196462; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome aa3-600 quinol oxidase (subunit III)" /protein_id="NP_391694.1" /db_xref="EnsemblGenomes-Gn:BSU38150" /db_xref="EnsemblGenomes-Tr:CAB15841" /db_xref="GOA:P34958" /db_xref="InterPro:IPR000298" /db_xref="InterPro:IPR013833" /db_xref="InterPro:IPR014246" /db_xref="InterPro:IPR024791" /db_xref="InterPro:IPR033946" /db_xref="InterPro:IPR035973" /db_xref="SubtiList:BG10585" /db_xref="UniProtKB/Swiss-Prot:P34958" /translation="MEHAEHGNSNAPMEYQSETGRLNILGFWIFLGAEIVLFSTLFAT FFVLKNRTAGGVLPDELFEVNLVMIMTFLLLISSFTCGIAVHEMRRGSLKGVVIWTII TLLLGAGFVGCEINEFVHYVHEGAALSTSAFWSGFFVLLGTHGTHVTIGIFWITGILI QLKKRGLTPQTSSKIFISSLYWHFLDVVWIFIFTGVYLMGLGGL*" /label="qoxC CDS" gene complement(3531947..3532561) /gene="qoxC" /locus_tag="BSU_38150" /old_locus_tag="BSU38150" /label="qoxC gene" CDS complement(3532575..3534524) /gene="qoxB" /locus_tag="BSU_38160" /old_locus_tag="BSU38160" /EC_number="1.10.3.12" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1316894, 7495838, 7575098, 10551842, 15849754, 16850406, 22720735, 26196462" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1316894, 7495838, 7575098, 10551842, 15849754, 16850406, 22720735, 26196462; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome aa3-600 quinol oxidase (subunit I)" /protein_id="NP_391695.1" /db_xref="EnsemblGenomes-Gn:BSU38160" /db_xref="EnsemblGenomes-Tr:CAB15842" /db_xref="GOA:P34956" /db_xref="InterPro:IPR000883" /db_xref="InterPro:IPR014233" /db_xref="InterPro:IPR023615" /db_xref="InterPro:IPR023616" /db_xref="InterPro:IPR036927" /db_xref="SubtiList:BG10584" /db_xref="UniProtKB/Swiss-Prot:P34956" /translation="MKFKWDEFFVTGDPLILGAQVSIALSTIAIIFVLTYFKKWKWLW SEWITTVDHKKLGIMYIISAVIMLFRGGVDGLMMRAQLALPNNSFLDSNHYNEIFTTH GTIMIIFMAMPFLIGLINVVVPLQIGARDVAFPYLNNLSFWTFFVGAMLFNISFVIGG SPNAGWTSYMPLASNDMSPGPGENYYLLGLQIAGIGTLMTGINFMVTILKMRTKGMTL MRMPMFTWTTLITMVIIVFAFPVLTVALALLSFDRLFGAHFFTLEAGGMPMLWANLFW IWGHPEVYIVILPAFGIFSEIISSFARKQLFGYKAMVGSIIAISVLSFLVWTHHFFTM GNSASVNSFFSITTMAISIPTGVKIFNWLFTMYKGRISFTTPMLWALAFIPNFVIGGV TGVMLAMAAADYQYHNTYFLVSHFHYVLIAGTVFACFAGFIFWYPKMFGHKLNERIGK WFFWIFMIGFNICFFPQYFLGLQGMPRRIYTYGPNDGWTTLNFISTVGAFMMGVGFLI LCYNIYYSFRYSTREISGDSWGVGRTLDWATSSAIPPHYNFAVLPEVKSQDAFLHMKE EKTELYPESKFKKIHMPSNSGRPFFMSVAFGLAGFGLVFEWYWMGVVGLIGVLLCMVL RSFEYDNGYYISVDEIKETERKISE*" /label="qoxB CDS" gene complement(3532575..3534524) /gene="qoxB" /locus_tag="BSU_38160" /old_locus_tag="BSU38160" /label="qoxB gene" misc_feature 3533788..3533807 /Source="Nicolas_upshift_promotors" /id="U2998" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.869130869130869" /psig="0.894105894105894" /xcortree=62 /SigmaFactorBS="gcttccaatgtgaaaaagtgagcgccgaacaaacgatcaaat gataaaagtgctAATGCTACTGTAAGTACAGGgaacgcaaacacgataataaccattg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3533794 /Source="Nicolas_upshifts" /id="U2998" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.869130869130869" /psig="0.894105894105894" /xcortree=62 /SigmaFactorBS="gcttccaatgtgaaaaagtgagcgccgaacaaacgatcaaat gataaaagtgctAATGCTACTGTAAGTACAGGgaacgcaaacacgataataaccattg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_no_box 3534218..3534318 /Source="Nicolas_upshift_promotors" /id="U2999" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.915084915084915" /psig="0.002997002997003" /xcortree=78 /SigmaFactorBS="cgtgagttgtaaaaatttcattatagtggtttgagtctaaaa aactgttattcggaagcgctagctgggcacgcatcatcagaccgtcgacaccgccacg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 3534278 /Source="Nicolas_upshifts" /id="U2999" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.915084915084915" /psig="0.002997002997003" /xcortree=78 /SigmaFactorBS="cgtgagttgtaaaaatttcattatagtggtttgagtctaaaa aactgttattcggaagcgctagctgggcacgcatcatcagaccgtcgacaccgccacg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 3534388 /Source="Nicolas_upshifts" /id="D1974" /incds=1 /nref=1 /ntot=73 /MaxReadThrough="3.07388" /MaxDrop="3.44223" /score="-7.14620582" /energy="-8.1" /TU="U2999" /idTUdmin="U2999" /TUdmin="-154" /isTUend="FALSE" /label="downshifts" CDS complement(3534552..3535517) /gene="qoxA" /locus_tag="BSU_38170" /old_locus_tag="BSU38170" /EC_number="1.10.3.12" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1316894, 7495838, 7575098, 10551842, 22720735, 26196462" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1316894, 7495838, 7575098, 10551842, 22720735, 26196462; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cytochrome aa3-600 quinol oxidase (subunit II)" /protein_id="NP_391696.2" /db_xref="EnsemblGenomes-Gn:BSU38170" /db_xref="EnsemblGenomes-Tr:CAB15843" /db_xref="GOA:P34957" /db_xref="InterPro:IPR002429" /db_xref="InterPro:IPR006332" /db_xref="InterPro:IPR006333" /db_xref="InterPro:IPR008972" /db_xref="InterPro:IPR011759" /db_xref="InterPro:IPR034227" /db_xref="InterPro:IPR036257" /db_xref="SubtiList:BG10583" /db_xref="UniProtKB/Swiss-Prot:P34957" /translation="MIFLFRALKPLLVLALLTVVFVLGGCSNASVLDPKGPVAEQQSD LILLSIGFMLFIVGVVFVLFTIILVKYRDRKGKDNGSYNPEIHGNTFLEVVWTVIPIL IVIALSVPTVQTIYSLEKAPEATKDKEPLVVYATSVDWKWVFSYPEQDIETVNYLNIP VDRPILFKISSADSMASLWIPQLGGQKYAMAGMLMDQYLQADKVGTYEGRNANFTGEH FADQEFDVNAVTEKDFNSWVKKTQNEAPKLTKEKYDELMLPENVDELTFSSTHLKYVD HGQDAEYAMEARKRLGYQAVSPHSKTDPFENVKKNEFKKSDDTEE*" /label="qoxA CDS" gene complement(3534552..3535517) /gene="qoxA" /locus_tag="BSU_38170" /old_locus_tag="BSU38170" /label="qoxA gene" S_feature complement(3535518..3535586) /Source="Nicolas_S_feature" /locus_tag="new_3918262_3918330_c" /HighExp="M0t90, M40t90, Lbtran, Lbstat, M40t45, S2, nit, ferm, LBGstat, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigEF" /TUshortPSig="0.626, 1, 1, 0.95" /TUlongSig="NA" /TUlongPSig="NA" /label="S1471" promotor_-10 complement(3535573..3535592) /Source="Nicolas_upshift_promotors" /id="U3000" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.30969030969031" /psig="0.626373626373626" /xcortree=2709 /SigmaFactorBS="taagcgaaaatgggatgaagtttataaaaaaataaagCTAAT aagtgaagttttTGATAGCATAACAAAGTAGAgaaaagattttgaggaagtatgcact t" /listShort="S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3535586) /Source="Nicolas_upshifts" /id="U3000" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.30969030969031" /psig="0.626373626373626" /xcortree=2709 /SigmaFactorBS="taagcgaaaatgggatgaagtttataaaaaaataaagCTAAT aagtgaagttttTGATAGCATAACAAAGTAGAgaaaagattttgaggaagtatgcact t" /listShort="S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3535588..3535773) /Source="Nicolas_S_feature" /locus_tag="new_3918332_3918517_c" /HighExp="LBGstat, Heat, G150, G135, LBGtran, G180, BMM, Salt, LBGexp, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigEF" /TUshortPSig="1, 1, 0.95" /TUlongSig="NA" /TUlongPSig="NA" /label="S1472" promotor_-35 complement(3535605..3535609) /Source="Nicolas_upshift_promotors" /id="U3000" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.30969030969031" /psig="0.626373626373626" /xcortree=2709 /SigmaFactorBS="taagcgaaaatgggatgaagtttataaaaaaataaagCTAAT aagtgaagttttTGATAGCATAACAAAGTAGAgaaaagattttgaggaagtatgcact t" /listShort="S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3535704..3535709 /Source="Nicolas_upshift_promotors" /id="U3001" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.903096903096903" /psig="0.903096903096903" /xcortree=792 /SigmaFactorBS="tgctccaactttattcacatctatcgcttaagatGAAAAGtt tctagttatttccGCATATAAAGTAAAGAAAGatgatgaagaactaattctgacaaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3535725..3535743 /Source="Nicolas_upshift_promotors" /id="U3001" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.903096903096903" /psig="0.903096903096903" /xcortree=792 /SigmaFactorBS="tgctccaactttattcacatctatcgcttaagatGAAAAGtt tctagttatttccGCATATAAAGTAAAGAAAGatgatgaagaactaattctgacaaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3535730 /Source="Nicolas_upshifts" /id="U3001" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.903096903096903" /psig="0.903096903096903" /xcortree=792 /SigmaFactorBS="tgctccaactttattcacatctatcgcttaagatGAAAAGtt tctagttatttccGCATATAAAGTAAAGAAAGatgatgaagaactaattctgacaaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3535764..3535783) /Source="Nicolas_upshift_promotors" /id="U3002" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=2699 /SigmaFactorBS="atctagaaagtttaacaaaatgaaatttttgATTGAcctaag ttttttatTGTGGTAAACCTTAATTTGTcagaattagttcttcatcatctttctttac t" /listShort="S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3535773) /Source="Nicolas_upshifts" /id="U3002" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=2699 /SigmaFactorBS="atctagaaagtttaacaaaatgaaatttttgATTGAcctaag ttttttatTGTGGTAAACCTTAATTTGTcagaattagttcttcatcatctttctttac t" /listShort="S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3535775..3535884) /Source="Nicolas_S_feature" /locus_tag="new_3918519_3918628_c" /HighExp="Heat, Salt, LBGstat, BMM, Oxctl, H2O2, MG 15, UNK1, MG-0.1, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 0.95" /TUlongSig="NA" /TUlongPSig="NA" /label="S1473" promotor_-35 complement(3535798..3535802) /Source="Nicolas_upshift_promotors" /id="U3002" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=2699 /SigmaFactorBS="atctagaaagtttaacaaaatgaaatttttgATTGAcctaag ttttttatTGTGGTAAACCTTAATTTGTcagaattagttcttcatcatctttctttac t" /listShort="S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3535840 /Source="Nicolas_upshifts" /id="D1975" /incds=0 /nref=3 /ntot=21 /MaxReadThrough="2.69533" /MaxDrop="4.01393" /score="13.5410442" /energy="-16.4" /TU="U3001" /idTUdmin="U3001" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3535869..3535888) /Source="Nicolas_upshift_promotors" /id="U3003" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2528 /SigmaFactorBS="tacggacaattcagagcatattggctcttcattgcgCCTTTt ctttcaatatttgaTGCGTTAAAATGGTAACCGTgtgaaaagatgctagacgaggaaa a" /listShort="S1473, S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3535884) /Source="Nicolas_upshifts" /id="U3003" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2528 /SigmaFactorBS="tacggacaattcagagcatattggctcttcattgcgCCTTTt ctttcaatatttgaTGCGTTAAAATGGTAACCGTgtgaaaagatgctagacgaggaaa a" /listShort="S1473, S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3535904..3535908) /Source="Nicolas_upshift_promotors" /id="U3003" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2528 /SigmaFactorBS="tacggacaattcagagcatattggctcttcattgcgCCTTTt ctttcaatatttgaTGCGTTAAAATGGTAACCGTgtgaaaagatgctagacgaggaaa a" /listShort="S1473, S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3535962..3535980) /Source="Nicolas_upshift_promotors" /id="U3004" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.95004995004995" /psig="0.95004995004995" /xcortree=1019 /SigmaFactorBS="aactcatcatgcaacacatcctattttttatttatttgCTTA TAtcattcctcttttttGTATAAGATAAACAACTGGatgctctcataaaaaaatacgg a" /listShort="S1473, S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 3535967..3535973 /Source="Nicolas_upshift_promotors" /id="U3005" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=241 /SigmaFactorBS="ctgaattgtccgtatttttttatgagagcatccagtTGTTTA TcttatacaaaaaagAGGAATGATATAAGCAAATaaataaaaaataggatgtgttgca t" /listShort="ywzA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3535979) /Source="Nicolas_upshifts" /id="U3004" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.95004995004995" /psig="0.95004995004995" /xcortree=1019 /SigmaFactorBS="aactcatcatgcaacacatcctattttttatttatttgCTTA TAtcattcctcttttttGTATAAGATAAACAACTGGatgctctcataaaaaaatacgg a" /listShort="S1473, S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3535988..3536006 /Source="Nicolas_upshift_promotors" /id="U3005" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=241 /SigmaFactorBS="ctgaattgtccgtatttttttatgagagcatccagtTGTTTA TcttatacaaaaaagAGGAATGATATAAGCAAATaaataaaaaataggatgtgttgca t" /listShort="ywzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3535991 /Source="Nicolas_upshifts" /id="U3005" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=241 /SigmaFactorBS="ctgaattgtccgtatttttttatgagagcatccagtTGTTTA TcttatacaaaaaagAGGAATGATATAAGCAAATaaataaaaaataggatgtgttgca t" /listShort="ywzA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3535996..3536001) /Source="Nicolas_upshift_promotors" /id="U3004" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.95004995004995" /psig="0.95004995004995" /xcortree=1019 /SigmaFactorBS="aactcatcatgcaacacatcctattttttatttatttgCTTA TAtcattcctcttttttGTATAAGATAAACAACTGGatgctctcataaaaaaatacgg a" /listShort="S1473, S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3536033..3536278 /gene="ywzA" /locus_tag="BSU_38180" /old_locus_tag="BSU38180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391697.2" /db_xref="EnsemblGenomes-Gn:BSU38180" /db_xref="EnsemblGenomes-Tr:CAB15844" /db_xref="GOA:O32282" /db_xref="InterPro:IPR007341" /db_xref="SubtiList:BG14162" /db_xref="UniProtKB/Swiss-Prot:O32282" /translation="MSFLISLIVAIIIGWLGSLFVKGDMPGGIIGSMIAGLIGAWIGH GLLGTWGPHLAGFAIIPAVIGAAIVVFLVSLLTRKRG*" /label="ywzA CDS" gene 3536033..3536278 /gene="ywzA" /locus_tag="BSU_38180" /old_locus_tag="BSU38180" /label="ywzA gene" downshifts 3536260 /Source="Nicolas_upshifts" /id="D1976" /incds=0 /nref=125 /ntot=189 /MaxReadThrough="2.63086" /MaxDrop="7.72876" /score="13.5410442" /energy="-16.4" /TU="NA" /idTUdmin="U3005" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(3536349..3537890) /gene="galT" /locus_tag="BSU_38190" /old_locus_tag="BSU38190" /EC_number="2.7.7.12" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2104611, 9555917, 11790749" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2104611, 9555917, 11790749; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="galactose-1-phosphate uridyltransferase" /protein_id="NP_391698.2" /db_xref="EnsemblGenomes-Gn:BSU38190" /db_xref="EnsemblGenomes-Tr:CAB15845" /db_xref="GOA:P39575" /db_xref="InterPro:IPR000766" /db_xref="InterPro:IPR005849" /db_xref="InterPro:IPR005850" /db_xref="InterPro:IPR023425" /db_xref="SubtiList:BG10582" /db_xref="UniProtKB/Swiss-Prot:P39575" /translation="MSIIEHLEQLLEYGLERKLISIWDREYTRNRLYEALGITHPEPN SSTSIKQSQSLPDLLAPIYKWAAETGRMEADTDTYRDLLSAKLMGCFVPAPSEVIRKF EETKALYGPKQATKEFYQYSEDVYYIRTDRIAKNVHWTVPTEYGELEMTINLSKPEKD PKAIAAAKEQEQTNYPMCLLCKENVGFEGSVNHPARQNHRIIPVILEDEQWFLQFSPY VYYPEHCIVLKGEHEPMEISKKTFERLLSFLGQYPHYFIGSNADLPIVGGSILSHDHF QGGAHDFPMARAEAEDVYELNDYPGVSLGLVKWPMSVLRLQGDEPGHVAEAADHIFRT WQTYSDEKAGIAAYTGDTPHNTVTPIARRRGDLYELDIVLRNNRTDEEHPLGIFHPHQ EVHHIKKENIGLIEVMGLAILPGRLQEEMKETAAALCSADPKTALEQNPLTAKHSEWA LRTMEKRTITKENVDLVIKEELGHVFARILEHAGVFKQTAEGKQAFRRFIDQLGAKPV KSLNR*" /label="galT CDS" gene complement(3536349..3537890) /gene="galT" /locus_tag="BSU_38190" /old_locus_tag="BSU38190" /label="galT gene" downshifts complement(3536378) /Source="Nicolas_upshifts" /id="D1977" /incds=0 /nref=190 /ntot=254 /MaxReadThrough="0.3431" /MaxDrop="6.63153" /score="21.0691542" /energy="-14.7" /TU="NA" /idTUdmin="U3006" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3537894..3539066) /gene="galK" /locus_tag="BSU_38200" /old_locus_tag="BSU38200" /EC_number="2.7.1.6" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2104611, 9555917" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2104611, 9555917; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="galactokinase" /protein_id="NP_391699.1" /db_xref="EnsemblGenomes-Gn:BSU38200" /db_xref="EnsemblGenomes-Tr:CAB15846" /db_xref="GOA:P39574" /db_xref="InterPro:IPR000705" /db_xref="InterPro:IPR006203" /db_xref="InterPro:IPR006204" /db_xref="InterPro:IPR006206" /db_xref="InterPro:IPR013750" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR019539" /db_xref="InterPro:IPR019741" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR022963" /db_xref="InterPro:IPR036554" /db_xref="SubtiList:BG10581" /db_xref="UniProtKB/Swiss-Prot:P39574" /translation="MREELKGIFASVFGEKEGLRFFFAPGRVNLIGEHTDYNGGHVFP CALTMGTYAAVAERNDGLVRMYSDNFRNAGIKECSLDDIRYQKEDDWANYPKGVIYEF QQRGYAVPHGFDIVFSGNIPNGAGLSSSASIELLMGVVLQSYFHPEVDALELVKMAQH AENHFIGVNCGIMDQFAIGMGKKHHAMLLNCDTLDYEYSKLNVSGLALVIANTNKKRT LADSSYNTRRQECNDALLDLKKGLDIAALGDIKPSDFDAHSSLIQNETNRRRAKHAVY ENHRAIKTAHMFKENNIDEIGQLMKESHLSLKDDYEVTCPELDELVFAAWDHEGVIGS RMTGAGFGGCTISIVKDEFVDDFIQKVGDRYQEKTGLRADFYVADIGEGARELKGE*" /label="galK CDS" gene complement(3537894..3539066) /gene="galK" /locus_tag="BSU_38200" /old_locus_tag="BSU38200" /label="galK gene" promotor_-10 complement(3539084..3539102) /Source="Nicolas_upshift_promotors" /id="U3006" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=170 /SigmaFactorBS="caaaagaagaaggggtatgagaggactgcagcatatgatctg cCGTTTTCtatgaagaaataagGGGAATAAAAAATAAAAACcagaaaggtgattgcac a" /listShort="galK, galT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3539106) /Source="Nicolas_upshifts" /id="U3006" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=170 /SigmaFactorBS="caaaagaagaaggggtatgagaggactgcagcatatgatctg cCGTTTTCtatgaagaaataagGGGAATAAAAAATAAAAACcagaaaggtgattgcac a" /listShort="galK, galT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3539117..3539123) /Source="Nicolas_upshift_promotors" /id="U3006" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=170 /SigmaFactorBS="caaaagaagaaggggtatgagaggactgcagcatatgatctg cCGTTTTCtatgaagaaataagGGGAATAAAAAATAAAAACcagaaaggtgattgcac a" /listShort="galK, galT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3539147..3539530) /gene="ywcD" /locus_tag="BSU_38210" /old_locus_tag="BSU38210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9882654, 15849754, 16850406, 18192405; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative cell wall glycosylation protein" /protein_id="NP_391700.1" /db_xref="EnsemblGenomes-Gn:BSU38210" /db_xref="EnsemblGenomes-Tr:CAB15847" /db_xref="GOA:P39602" /db_xref="InterPro:IPR007267" /db_xref="SubtiList:BG10580" /db_xref="UniProtKB/Swiss-Prot:P39602" /translation="MYIIMGVFTTIVNIASFYILVEIMNVDYKAATVAAWILSVLFAY ITNKLYVFQQKTHDLQSLLKELTAFFSVRVLSLGIDLGMMIILVGQFNTNETLAKILD NAVIVVVNYVASKWLVFKKTKEEGV*" /label="ywcD CDS" gene complement(3539147..3539530) /gene="ywcD" /locus_tag="BSU_38210" /old_locus_tag="BSU38210" /label="ywcD gene" CDS complement(3539548..3540219) /gene="slrC" /locus_tag="BSU_38220" /old_locus_tag="BSU38220" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18647168" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18647168; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of slrA (biofilm formation)" /protein_id="NP_391701.2" /db_xref="EnsemblGenomes-Gn:BSU38220" /db_xref="EnsemblGenomes-Tr:CAB15848" /db_xref="GOA:P39601" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG10579" /db_xref="UniProtKB/Swiss-Prot:P39601" /translation="MKKNKFQIKREATFESFIDAGVNLLIDRAYDPVSVEDISRAAGY SKGAFYVHFVSKDDFLLYLLEKRQMKKKIIIGYLDQMERESVKSLTLDEAAKHAAELL YSYYINKPSWDITSFAMNMPTYKVLKKCKAYVRLYELWVEENVLYIKWLKERKLIDAC IDPEYTAKIICAVLDGIIKQSYVLGQPATFRSFLDALSVFFTLDREHERPRILKSFSE SEEHQ*" /label="slrC CDS" gene complement(3539548..3540219) /gene="slrC" /locus_tag="BSU_38220" /old_locus_tag="BSU38220" /label="slrC gene" promotor_-10 complement(3540241..3540260) /Source="Nicolas_upshift_promotors" /id="U3007" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.715284715284715" /psig="0.987012987012987" /xcortree=2081 /SigmaFactorBS="aaccgaatagcataaccgtttaaagaaataaATACcgctaaa gattgatcCGGTGTAAGATAAGGGTAATcattaccgccaggagaaaaatatgaaaaaa a" /listShort="ywcC, ywcD, galK, galT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3540250) /Source="Nicolas_upshifts" /id="U3007" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.715284715284715" /psig="0.987012987012987" /xcortree=2081 /SigmaFactorBS="aaccgaatagcataaccgtttaaagaaataaATACcgctaaa gattgatcCGGTGTAAGATAAGGGTAATcattaccgccaggagaaaaatatgaaaaaa a" /listShort="ywcC, ywcD, galK, galT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3540276..3540279) /Source="Nicolas_upshift_promotors" /id="U3007" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.715284715284715" /psig="0.987012987012987" /xcortree=2081 /SigmaFactorBS="aaccgaatagcataaccgtttaaagaaataaATACcgctaaa gattgatcCGGTGTAAGATAAGGGTAATcattaccgccaggagaaaaatatgaaaaaa a" /listShort="ywcC, ywcD, galK, galT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3540360..3540363 /Source="Nicolas_upshift_promotors" /id="U3008" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.518481518481518" /psig="0.996003996003996" /xcortree=3106 /SigmaFactorBS="taataggctaaatgatttattttcatttacataCTATccagt cagtatttaATTGTTTATTATTATAAATAaggtccattggttatattagtcatttttt t" /listShort="S1474, slrA, S1475, ywcB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3540378..3540397 /Source="Nicolas_upshift_promotors" /id="U3008" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.518481518481518" /psig="0.996003996003996" /xcortree=3106 /SigmaFactorBS="taataggctaaatgatttattttcatttacataCTATccagt cagtatttaATTGTTTATTATTATAAATAaggtccattggttatattagtcatttttt t" /listShort="S1474, slrA, S1475, ywcB" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3540387..3540574 /Source="Nicolas_S_feature" /locus_tag="new_3923131_3923318" /HighExp="T0.30H, T1.0H, Cold, T1.30H, HiOs, T-0.40H, T2.0H, T2.30H, T4.0H, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1474" upshifts 3540387 /Source="Nicolas_upshifts" /id="U3008" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.518481518481518" /psig="0.996003996003996" /xcortree=3106 /SigmaFactorBS="taataggctaaatgatttattttcatttacataCTATccagt cagtatttaATTGTTTATTATTATAAATAaggtccattggttatattagtcatttttt t" /listShort="S1474, slrA, S1475, ywcB" /GFF_Attribute="listLong" /label="upshifts" CDS 3540575..3540733 /gene="slrA" /locus_tag="BSU_38229" /old_locus_tag="BSU38229" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18647168, 26857544" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18647168, 26857544; Product type r: regulator" /codon_start=1 /transl_table=11 /product="anti-repressor of SlrR" /protein_id="YP_003097794.1" /db_xref="EnsemblGenomes-Gn:BSU38229" /db_xref="EnsemblGenomes-Tr:CAX52707" /db_xref="GOA:P0C8M5" /db_xref="InterPro:IPR010981" /db_xref="InterPro:IPR036281" /db_xref="UniProtKB/Swiss-Prot:P0C8M5" /translation="MKTHVKKDLDKGWHMLIQEARSIGLGIHDVRQFLESETASRKKN HKKTVRQD*" /label="slrA CDS" gene 3540575..3540733 /gene="slrA" /locus_tag="BSU_38229" /old_locus_tag="BSU38229" /label="slrA gene" S_feature 3540734..3541118 /Source="Nicolas_S_feature" /locus_tag="new_3923478_3923862" /HighExp="T0.30H, Cold, T1.30H, T2.0H, T1.0H, HiOs, T2.30H, T3.0H, LBGstat, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1475" promotor_-35 3541099..3541104 /Source="Nicolas_upshift_promotors" /id="U3009" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1051 /SigmaFactorBS="acgacttccttcttttttcatcctccagctattgtacaaCGC ATAaatcggactttcagtACATACCTATTGGTGTACCtttttgcttacgtttagcgaa t" /listShort="ywcB, ywcA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3541120..3541138 /Source="Nicolas_upshift_promotors" /id="U3009" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1051 /SigmaFactorBS="acgacttccttcttttttcatcctccagctattgtacaaCGC ATAaatcggactttcagtACATACCTATTGGTGTACCtttttgcttacgtttagcgaa t" /listShort="ywcB, ywcA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3541120 /Source="Nicolas_upshifts" /id="U3009" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1051 /SigmaFactorBS="acgacttccttcttttttcatcctccagctattgtacaaCGC ATAaatcggactttcagtACATACCTATTGGTGTACCtttttgcttacgtttagcgaa t" /listShort="ywcB, ywcA" /GFF_Attribute="listLong" /label="upshifts" CDS 3541176..3541484 /gene="vbfB" /locus_tag="BSU_38230" /old_locus_tag="BSU38230" /function="16.1: Circulate" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:26060272, 28357266" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 26060272, 28357266; Product type t: transporter" /codon_start=1 /transl_table=11 /product="subunit of acetate transporter as a volatile signal for biofilm formation" /protein_id="NP_391702.1" /db_xref="EnsemblGenomes-Gn:BSU38230" /db_xref="EnsemblGenomes-Tr:CAB15849" /db_xref="GOA:P39600" /db_xref="InterPro:IPR007436" /db_xref="SubtiList:BG10578" /db_xref="UniProtKB/Swiss-Prot:P39600" /translation="MYKADYKQIAATPSFQAFLKQKRAFIVPSAIFFFVFYFSLPVLT SYFTFLNAPAIGAVSWAWLFAIAQFAMTWILSTVYSRRAAHFDKYVSALKEDLKGEQT *" /label="vbfB CDS" gene 3541176..3541484 /gene="vbfB" /locus_tag="BSU_38230" /old_locus_tag="BSU38230" /label="vbfB gene" downshifts complement(3541262) /Source="Nicolas_upshifts" /id="D1978" /incds=1 /nref=3 /ntot=15 /MaxReadThrough="0.42282" /MaxDrop="5.4957" /score="10.1452497" /energy="-8.3" /TU="NA" /idTUdmin="U3010" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_no_box complement(3541266..3541366) /Source="Nicolas_upshift_promotors" /id="U3010" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.731268731268731" /psig="0.017982017982018" /xcortree=279 /SigmaFactorBS="aacagccaagcccatgaaacagctccaatggccggtgcattc aaaaaggtgaaataagatgtcaaaacagggagtgaaaaataaaaaacaaaaaagaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(3541306) /Source="Nicolas_upshifts" /id="U3010" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.731268731268731" /psig="0.017982017982018" /xcortree=279 /SigmaFactorBS="aacagccaagcccatgaaacagctccaatggccggtgcattc aaaaaggtgaaataagatgtcaaaacagggagtgaaaaataaaaaacaaaaaagaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 3541481..3543022 /gene="vbfA" /locus_tag="BSU_38240" /old_locus_tag="BSU38240" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 26060272, 28357266" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 26060272, 28357266; Product type t: transporter" /codon_start=1 /transl_table=11 /product="acetate Na+-dependent symporter subunit involvedin volatile signal for biofilm formation" /protein_id="NP_391703.2" /db_xref="EnsemblGenomes-Gn:BSU38240" /db_xref="EnsemblGenomes-Tr:CAB15850" /db_xref="GOA:P39599" /db_xref="InterPro:IPR001734" /db_xref="InterPro:IPR018212" /db_xref="SubtiList:BG10577" /db_xref="UniProtKB/Swiss-Prot:P39599" /translation="MNMTAFLLFLAIVGLTLIITYFAAKRTKTTSEFYTAGGGLTGVQ NGLAIAGDYMSAASFLGIAGMIALYGFDGFFYSIGFLVAYLVVLYIVAEPLRNLGKYT MADMIAARFKEKKIRGVAALNTIAISTFYMIAQLVGAGALIKLLLGLDYTAAVLIVGV LMTIYVVFGGMIATSWVQIIKAVLLMAGTLVISIIVFSKFGFSLNTMFEQMKTATPLG ADFLNPGNKYKVPLETLSLNLALVLGTAGLPHILIRFYTVKDAKTARTSVVSATWIIG VFYIMTVFLGFGAAAFVGFDAITAADQAGNMAAPLLAKALGGDFLFAFVSAIAFATIL AVVTGLVLSAASAFAHDIYSQIIRKGEATEKEQMKAARWASVAVSVLSILLAIFAQSL NVAFLVALAFAVAASANLPLIVFTVFWKRFNASGALWGSLTGLISALVLVSMSPSVWD PAGGAIFTGDPLIPLSNPGIISIPLGFLGAWLGTVLSSDKTIDEDTFAEIQVKAHTGV HMEQE*" /label="vbfA CDS" gene 3541481..3543022 /gene="vbfA" /locus_tag="BSU_38240" /old_locus_tag="BSU38240" /label="vbfA gene" downshifts 3543013 /Source="Nicolas_upshifts" /id="D1979" /incds=0 /nref=4 /ntot=35 /MaxReadThrough="2.40129" /MaxDrop="4.15104" /score="2.66606932" /energy="-7.8" /TU="NA" /idTUdmin="U3009" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3543053..3543655) /gene="ywbO" /locus_tag="BSU_38250" /old_locus_tag="BSU38250" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sulfur oxido-reductase" /protein_id="NP_391704.1" /db_xref="EnsemblGenomes-Gn:BSU38250" /db_xref="EnsemblGenomes-Tr:CAB15851" /db_xref="GOA:P39598" /db_xref="InterPro:IPR001853" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG10576" /db_xref="UniProtKB/Swiss-Prot:P39598" /translation="MTVHIKVYSDYVCPFCFVGKAAFEEAIKGKDVEVEWMPFELRPS PSPQLDPVNDPSKQYMWQTSIQPMAEKLGVEINFPNVSPHPYTDLAFEGFHFAKEYNK GHEYNTRVFQAFFQEDQNIGDIDILTKLAEEVGLDGASFKSALETRTYQDVQRQALKH AYEEADITAVPTFIIGDTVIPGAAGKDVFEKAISDEQKKK*" /label="ywbO CDS" gene complement(3543053..3543655) /gene="ywbO" /locus_tag="BSU_38250" /old_locus_tag="BSU38250" /label="ywbO gene" downshifts complement(3543067) /Source="Nicolas_upshifts" /id="D1980" /incds=0 /nref=12 /ntot=123 /MaxReadThrough="1.89374" /MaxDrop="3.51247" /score="21.9354981" /energy="-7.8" /TU="NA" /idTUdmin="U3011" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3543656..3543937) /Source="Nicolas_S_feature" /locus_tag="new_3926400_3926681_c" /HighExp="T1.0H, G135, G150, T1.30H, Lbexp, G180, Lbstat, dia5, LBGexp, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.984, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1476" CDS complement(3543938..3545188) /gene="efeB" /locus_tag="BSU_38260" /old_locus_tag="BSU38260" /EC_number="1.11.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15554971, 16672620, 16987175, 18931290, 19383693, 21479178, 23764491, 24620988, 27795321" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15554971, 16672620, 16987175, 18931290, 19383693, 21479178, 23764491, 24620988, 27795321; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peroxidase converting ferric iron into ferrous iron" /protein_id="NP_391705.1" /db_xref="EnsemblGenomes-Gn:BSU38260" /db_xref="EnsemblGenomes-Tr:CAB15852" /db_xref="GOA:P39597" /db_xref="InterPro:IPR006311" /db_xref="InterPro:IPR006313" /db_xref="InterPro:IPR006314" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR019546" /db_xref="SubtiList:BG10575" /db_xref="UniProtKB/Swiss-Prot:P39597" /translation="MSDEQKKPEQIHRRDILKWGAMAGAAVAIGASGLGGLAPLVQTA AKPSKKDEKEEEQIVPFYGKHQAGITTAHQTYVYFAALDVTAKDKSDIITLFRNWTSL TQMLTSGKKMSAEQRNQYLPPQDTGESADLSPSNLTVTFGFGPGFFEKDGKDRFGLKS KKPKHLAALPAMPNDNLDEKQGGGDICIQVCADDEQVAFHALRNLLNQAVGTCEVRFV NKGFLSGGKNGETPRNLFGFKDGTGNQSTKDDTLMNSIVWIQSGEPDWMTGGTYMAFR KIKMFLEVWDRSSLKDQEDTFGRRKSSGAPFGQKKETDPVKLNQIPSNSHVSLAKSTG KQILRRAFSYTEGLDPKTGYMDAGLLFISFQKNPDNQFIPMLKALSAKDALNEYTQTI GSALYACPGGCKKGEYIAQRLLES*" /label="efeB CDS" gene complement(3543938..3545188) /gene="efeB" /locus_tag="BSU_38260" /old_locus_tag="BSU38260" /label="efeB gene" downshifts complement(3544034) /Source="Nicolas_upshifts" /id="D1981" /incds=1 /nref=67 /ntot=232 /MaxReadThrough="5.0552" /MaxDrop="3.65898" /score="21.9354981" /energy="-7.8" /TU="U3011,U3012" /idTUdmin="U3011" /TUdmin="-967" /isTUend="FALSE" /label="downshifts" CDS complement(3545207..3546364) /gene="efeM" /locus_tag="BSU_38270" /old_locus_tag="BSU38270" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16672620, 16850406, 16987175, 23764491, 27795321" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16672620, 16850406, 16987175, 23764491, 27795321; Product type t: transporter" /codon_start=1 /transl_table=11 /product="lipoprotein binding ferrous or ferric iron for transport" /protein_id="NP_391706.1" /db_xref="EnsemblGenomes-Gn:BSU38270" /db_xref="EnsemblGenomes-Tr:CAB15853" /db_xref="GOA:P39596" /db_xref="InterPro:IPR018976" /db_xref="InterPro:IPR034981" /db_xref="SubtiList:BG10574" /db_xref="UniProtKB/Swiss-Prot:P39596" /translation="MNFTKIAVSAGCILALCAGCGANDTSSTKEKASSEKSGVTKEIT ASVNKMETIISKLNDSVEKGDQKEIEKKGKELNSYWLSFENDIRSDYPFEYTEIEKHL QPIYTEAQKDKPDAGKIKTESESLKASLEDLTEAKKSGKKASDQLAKAADEYKGYVKE QSDQLVKATEAFTGAVKSGDIEKSKTLYAKARVYYERIEPIAESLGDLDPKIDAREND VEEGDKWTGFHKLEKAIWKDQDISGEKATADQLLKDVKELDGSIQSLKLTPEQIVAGA MELLNEAGISKITGEEERYSRIDLVDLMANVEGSEAVYQTVKSALVKDHSDLTEKLDT EFSEFEVLMAKYKTNDQSYTSYDKLSEKQIRELSTKLTTLSETMSKIANVL*" /label="efeM CDS" gene complement(3545207..3546364) /gene="efeM" /locus_tag="BSU_38270" /old_locus_tag="BSU38270" /label="efeM gene" misc_feature complement(3545280..3545299) /Source="Nicolas_upshift_promotors" /id="U3011" /multdbtbs="SigW,SigX" /comp="M4" /sig="SigA" /pcomp="0.917082917082917" /psig="0.984015984015984" /xcortree=3235 /SigmaFactorBS="atacggagttcagcgaatttgaagttttaatggcaaaataca aaacaaatgatcagtcctatacgtctTATGATAAATTAAGTGAAAAgcaaatcagaga g" /listShort="efeN, S1476, ywbO" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3545307) /Source="Nicolas_upshifts" /id="U3011" /multdbtbs="SigW,SigX" /comp="M4" /sig="SigA" /pcomp="0.917082917082917" /psig="0.984015984015984" /xcortree=3235 /SigmaFactorBS="atacggagttcagcgaatttgaagttttaatggcaaaataca aaacaaatgatcagtcctatacgtctTATGATAAATTAAGTGAAAAgcaaatcagaga g" /listShort="efeN, S1476, ywbO" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3546361..3547806) /gene="efeU" /locus_tag="BSU_38280" /old_locus_tag="BSU38280" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16672620, 16850406, 16987175, 23764491, 27795321" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16672620, 16850406, 16987175, 23764491, 27795321; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ferrous ion permease" /protein_id="NP_391707.2" /db_xref="EnsemblGenomes-Gn:BSU38280" /db_xref="EnsemblGenomes-Tr:CAB15854" /db_xref="GOA:P39595" /db_xref="InterPro:IPR004923" /db_xref="SubtiList:BG10573" /db_xref="UniProtKB/Swiss-Prot:P39595" /translation="MARGLALILFSLLMVFGSAAHAEDDPIAALIQLNKQMIKSVKDG DMDSAQQTFDTFKAKWKKEEPSIKKENLSSHSEMDANIAMISLSFINQDARKLKTQLE ELASHLETYQQAVVLKKTSSGQSRASLTAYIQSLKDTKQFIEKKQLDEASSAIDNLVT SWLAVEGDVVSQSKEAYTTSEENLALMKAEIGSHPEKVSKQIDEMIQLLEPIASSSYS WWDAALIPVREGMEALLVIGALLTMTKKARVTRSSTWIWGGASAGMAVSLAAGIGVTV LFSSSVFGENNFLLGGVTGVLSAVMLLYVGVWLHRNASMDKWREKINIQKSQALKKRS LLSFALIAFLAVVREGLETVIFFIGLVGKLPLTELIGGTAAGLIVLVIVGVLMIKLGM RIPLKPFFLLSMAVVLYMCVKFLGTGVHSLQLAGILPSDAESWLPSVSVLGIYPSVYS TIPQMLILLFLLIALVSEAAKHFTNGKELTK*" /label="efeU CDS" gene complement(3546361..3547806) /gene="efeU" /locus_tag="BSU_38280" /old_locus_tag="BSU38280" /label="efeU gene" promotor_-10 complement(3547840..3547859) /Source="Nicolas_upshift_promotors" /id="U3012" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2103 /SigmaFactorBS="tccatcaaggttttcagaccttcaaattttAATTGACAaagg acaggaactGGCTATGATTATGTTATACAatgataatcattttcaattataggaggaa c" /listShort="efeU, efeM, efeN, S1476, ywbO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3547850) /Source="Nicolas_upshifts" /id="U3012" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2103 /SigmaFactorBS="tccatcaaggttttcagaccttcaaattttAATTGACAaagg acaggaactGGCTATGATTATGTTATACAatgataatcattttcaattataggaggaa c" /listShort="efeU, efeM, efeN, S1476, ywbO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3547873..3547880) /Source="Nicolas_upshift_promotors" /id="U3012" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2103 /SigmaFactorBS="tccatcaaggttttcagaccttcaaattttAATTGACAaagg acaggaactGGCTATGATTATGTTATACAatgataatcattttcaattataggaggaa c" /listShort="efeU, efeM, efeN, S1476, ywbO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3547963..3548631) /gene="thiE" /locus_tag="BSU_38290" /old_locus_tag="BSU38290" /EC_number="2.5.1.3" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10382260, 16291685, 19888457, 22616866; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thiamine-phosphate pyrophosphorylase (thiamine phosphate synthase)" /protein_id="NP_391708.1" /db_xref="EnsemblGenomes-Gn:BSU38290" /db_xref="EnsemblGenomes-Tr:CAB15855" /db_xref="GOA:P39594" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR022998" /db_xref="InterPro:IPR034291" /db_xref="InterPro:IPR036206" /db_xref="PDB:1G4E" /db_xref="PDB:1G4P" /db_xref="PDB:1G4S" /db_xref="PDB:1G4T" /db_xref="PDB:1G67" /db_xref="PDB:1G69" /db_xref="PDB:1G6C" /db_xref="PDB:2TPS" /db_xref="PDB:3O15" /db_xref="PDB:3O16" /db_xref="SubtiList:BG10572" /db_xref="UniProtKB/Swiss-Prot:P39594" /translation="MTRISREMMKELLSVYFIMGSNNTKADPVTVVQKALKGGATLYQ FREKGGDALTGEARIKFAEKAQAACREAGVPFIVNDDVELALNLKADGIHIGQEDANA KEVRAAIGDMILGVSAHTMSEVKQAEEDGADYVGLGPIYPTETKKDTRAVQGVSLIEA VRRQGISIPIVGIGGITIDNAAPVIQAGADGVSMISAISQAEDPESAARKFREEIQTY KTGR*" /label="thiE CDS" gene complement(3547963..3548631) /gene="thiE" /locus_tag="BSU_38290" /old_locus_tag="BSU38290" /label="thiE gene" downshifts complement(3547972) /Source="Nicolas_upshifts" /id="D1982" /incds=0 /nref=44 /ntot=194 /MaxReadThrough="1.62789" /MaxDrop="4.13196" /score="10.8502035" /energy="-10" /TU="NA" /idTUdmin="U3013" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3548628..3549446) /gene="thiM" /locus_tag="BSU_38300" /old_locus_tag="BSU38300" /EC_number="2.7.1.50" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10382260, 16291685, 22938038, 28729425" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10382260, 16291685, 22938038, 28729425; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-(2-hydroxyethyl)-4-methylthiazole kinase" /protein_id="NP_391709.1" /db_xref="EnsemblGenomes-Gn:BSU38300" /db_xref="EnsemblGenomes-Tr:CAB15856" /db_xref="GOA:P39593" /db_xref="InterPro:IPR000417" /db_xref="InterPro:IPR029056" /db_xref="PDB:1C3Q" /db_xref="PDB:1EKK" /db_xref="PDB:1EKQ" /db_xref="PDB:1ESJ" /db_xref="PDB:1ESQ" /db_xref="SubtiList:BG10571" /db_xref="UniProtKB/Swiss-Prot:P39593" /translation="MDAQSAAKCLTAVRRHSPLVHSITNNVVTNFTANGLLALGASPV MAYAKEEVADMAKIAGALVLNIGTLSKESVEAMIIAGKSANEHGVPVILDPVGAGATP FRTESARDIIREVRLAAIRGNAAEIAHTVGVTDWLIKGVDAGEGGGDIIRLAQQAAQK LNTVIAITGEVDVIADTSHVYTLHNGHKLLTKVTGAGCLLTSVVGAFCAVEENPLFAA IAAISSYGVAAQLAAQQTADKGPGSFQIELLNKLSTVTEQDVQEWATIERVTVS*" /label="thiM CDS" gene complement(3548628..3549446) /gene="thiM" /locus_tag="BSU_38300" /old_locus_tag="BSU38300" /label="thiM gene" CDS complement(3549454..3550359) /gene="cidR" /locus_tag="BSU_38310" /old_locus_tag="BSU38310" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 23504016; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (LysR family, cidAB expression)" /protein_id="NP_391710.1" /db_xref="EnsemblGenomes-Gn:BSU38310" /db_xref="EnsemblGenomes-Tr:CAB15857" /db_xref="GOA:P39592" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10570" /db_xref="UniProtKB/Swiss-Prot:P39592" /translation="MDIRHLTYFLEVARLKSFTKASQSLYVSQPTISKMIKNLEEELG IELFYRNGRQVELTDAGHSMYVQAQEIIKSFQNLTSELNDIMEVKKGHVRIGLPPMIG SGFFPRVLGDFRENYPNVTFQLVEDGSIKVQEGVGDGSLDIGVVVLPANEDIFHSFTI VKETLMLVVHPSHRLADEKECQLRELKDEPFIFFREDFVLHNRIMTECIKAGFRPHII YETSQWDFISEMVSANLGIGLLPERICRGLDPEKVKVIPLVDPVIPWHLAIIWRKDRY LSFAARAWLEHTKSYLWDPKKDSKG*" /label="cidR CDS" gene complement(3549454..3550359) /gene="cidR" /locus_tag="BSU_38310" /old_locus_tag="BSU38310" /label="cidR gene" misc_feature complement(3550094..3550113) /Source="Nicolas_upshift_promotors" /id="U3013" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.857142857142857" /psig="0.992007992007992" /xcortree=2665 /SigmaFactorBS="tgtgcaggcgcaggaaatcattaaatcatttcaaaacctgac gtcagaattaAATGATATTATGGAAGTCAAgaaagggcacgtacggattggactgccg c" /listShort="thiM, thiE" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3550105) /Source="Nicolas_upshifts" /id="U3013" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.857142857142857" /psig="0.992007992007992" /xcortree=2665 /SigmaFactorBS="tgtgcaggcgcaggaaatcattaaatcatttcaaaacctgac gtcagaattaAATGATATTATGGAAGTCAAgaaagggcacgtacggattggactgccg c" /listShort="thiM, thiE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3550400..3550419) /Source="Nicolas_upshift_promotors" /id="U3014" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig="0.996003996003996" /xcortree=2443 /SigmaFactorBS="agcaacagttttttcatattgatgcctcccttatatactTAT TGTACataaggtctctctatAGGTAAAATATATATTAAGAataagaagtattcctttt g" /listShort="ywbI, thiM, thiE" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 3550410..3550417 /Source="Nicolas_upshift_promotors" /id="U3015" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=2449 /SigmaFactorBS="cctttctatagacaaaaggaatacttcttattcttaatataT ATTTTACctatagagagaccTTATGTACAATAAGTATATAagggaggcatcaatatga a" /listShort="cidA, lrgB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3550421) /Source="Nicolas_upshifts" /id="U3014" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig="0.996003996003996" /xcortree=2443 /SigmaFactorBS="agcaacagttttttcatattgatgcctcccttatatactTAT TGTACataaggtctctctatAGGTAAAATATATATTAAGAataagaagtattcctttt g" /listShort="ywbI, thiM, thiE" /GFF_Attribute="listLong" /label="upshifts" upshifts 3550429 /Source="Nicolas_upshifts" /id="U3015" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=2449 /SigmaFactorBS="cctttctatagacaaaaggaatacttcttattcttaatataT ATTTTACctatagagagaccTTATGTACAATAAGTATATAagggaggcatcaatatga a" /listShort="cidA, lrgB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3550431..3550450 /Source="Nicolas_upshift_promotors" /id="U3015" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=2449 /SigmaFactorBS="cctttctatagacaaaaggaatacttcttattcttaatataT ATTTTACctatagagagaccTTATGTACAATAAGTATATAagggaggcatcaatatga a" /listShort="cidA, lrgB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3550435..3550442) /Source="Nicolas_upshift_promotors" /id="U3014" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig="0.996003996003996" /xcortree=2443 /SigmaFactorBS="agcaacagttttttcatattgatgcctcccttatatactTAT TGTACataaggtctctctatAGGTAAAATATATATTAAGAataagaagtattcctttt g" /listShort="ywbI, thiM, thiE" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3550465..3550851 /gene="cidA" /locus_tag="BSU_38320" /old_locus_tag="BSU38320" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15659658, 15849754, 16850406, 22383849, 26060272; Product type r: regulator" /codon_start=1 /transl_table=11 /product="metabolic regulator of murein hydrolases" /protein_id="NP_391711.1" /db_xref="EnsemblGenomes-Gn:BSU38320" /db_xref="EnsemblGenomes-Tr:CAB15858" /db_xref="GOA:P39591" /db_xref="InterPro:IPR005538" /db_xref="InterPro:IPR023760" /db_xref="SubtiList:BG10569" /db_xref="UniProtKB/Swiss-Prot:P39591" /translation="MKKLLLTVIQIALLFIFARLINWVTALLHINIPGSIIGIVILFT LLHFNIIKLEWIELGAAWLLGELLLFFIPSAVGVIEYGDIMSKFGVSILLVVIISTFV VMVSTGTLTQLIAKRKEKKHTCSSEL*" /label="cidA CDS" gene 3550465..3550851 /gene="cidA" /locus_tag="BSU_38320" /old_locus_tag="BSU38320" /label="cidA gene" CDS 3550833..3551510 /gene="cidB" /locus_tag="BSU_38330" /old_locus_tag="BSU38330" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15659658, 15849754, 16850406, 26060272; Product type r: regulator" /codon_start=1 /transl_table=11 /product="metabolic regulator controlling activity of murein hydrolases" /protein_id="NP_391712.2" /db_xref="EnsemblGenomes-Gn:BSU38330" /db_xref="EnsemblGenomes-Tr:CAB15859" /db_xref="GOA:P39590" /db_xref="InterPro:IPR005261" /db_xref="InterPro:IPR007300" /db_xref="SubtiList:BG10568" /db_xref="UniProtKB/Swiss-Prot:P39590" /translation="MFIGIVSLFLTVLVYLGAKKVYQRFPRVYTSPLLVTPAVLVGLL LLVNVPYESYNLGGGLLTDMLQPATVAFAIPLYKYFPVLKKYAVEIILNVAVGSCIAI ISTALIAKWLHLGTGLIDSLVPRSVTTPIAMNVSEMIGGMPAVTAVFVILTALLGTVI GPMVIRYFRIDNEIARGVLLGTSAHGAGTSKAFELSSVSGTISSVSMILAAIMTLCAA PFLLSFM*" /label="cidB CDS" gene 3550833..3551510 /gene="cidB" /locus_tag="BSU_38330" /old_locus_tag="BSU38330" /label="cidB gene" downshifts 3551482 /Source="Nicolas_upshifts" /id="D1983" /incds=0 /nref=13 /ntot=88 /MaxReadThrough="2.20109" /MaxDrop="4.23919" /score="27.0474383" /energy="-8" /TU="NA" /idTUdmin="U3015" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 3551554..3551561 /Source="Nicolas_upshift_promotors" /id="U3016" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.91008991008991" /psig="0.999000999001" /xcortree=3230 /SigmaFactorBS="aaactgtcctctcgagggcagttttttttatgtgcttcccct TATTGAAAagctggcgaattcCAATATAATGTATTTGTGGAtaccaaaggaggcaccc t" /listShort="ywbF, ywbE" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3551572 /Source="Nicolas_upshifts" /id="U3016" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.91008991008991" /psig="0.999000999001" /xcortree=3230 /SigmaFactorBS="aaactgtcctctcgagggcagttttttttatgtgcttcccct TATTGAAAagctggcgaattcCAATATAATGTATTTGTGGAtaccaaaggaggcaccc t" /listShort="ywbF, ywbE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3551575..3551594 /Source="Nicolas_upshift_promotors" /id="U3016" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.91008991008991" /psig="0.999000999001" /xcortree=3230 /SigmaFactorBS="aaactgtcctctcgagggcagttttttttatgtgcttcccct TATTGAAAagctggcgaattcCAATATAATGTATTTGTGGAtaccaaaggaggcaccc t" /listShort="ywbF, ywbE" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3551614..3552813 /gene="ywbF" /locus_tag="BSU_38340" /old_locus_tag="BSU38340" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sugar permease" /protein_id="NP_391713.1" /db_xref="EnsemblGenomes-Gn:BSU38340" /db_xref="EnsemblGenomes-Tr:CAB15860" /db_xref="GOA:P39589" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR024989" /db_xref="InterPro:IPR026032" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10567" /db_xref="UniProtKB/Swiss-Prot:P39589" /translation="MHNLQVRRHYAALKGFYLFAFLGTGSIIPLLSMYLTKEQHLSGS QVGLIMSLGPIVMIFFQPFWGMLSDYTQKTKGLLAVCTSITGIIGLAYIAFDSFPLFI LIAACFAAFQSTIIPLSDSISLRYTQETNGNYGGIRLFGSLGFGVAVFAMGQVTNQLY PIHVIFIFGCAFLCIAAILASQVPGQQKTTKVNIRKGFRELISNKTFLIFMIITFTTF APNLANNTYFSLFLDKSGASLSAIGILFFIGVISEIPFMRFAQTFIDKMGLLNVIMLS GGVSLFRWALYFTAPSLWIIYATVFLQGVAIGLFIPAALQYVKKITPRHVEATALTMY AAIGNGFGNWFCTFAGGYIFDYVSIFAVYLLFGILSIAGFGLTLYLMKAEKNKHTLHQ PAVTFKP*" /label="ywbF CDS" gene 3551614..3552813 /gene="ywbF" /locus_tag="BSU_38340" /old_locus_tag="BSU38340" /label="ywbF gene" CDS 3552847..3553044 /gene="ywbE" /locus_tag="BSU_38350" /old_locus_tag="BSU38350" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391714.1" /db_xref="EnsemblGenomes-Gn:BSU38350" /db_xref="EnsemblGenomes-Tr:CAB15861" /db_xref="InterPro:IPR019240" /db_xref="SubtiList:BG10566" /db_xref="UniProtKB/Swiss-Prot:P39588" /translation="MNGQERNSISKGLQVDIVLKADQKTGKLTRGTVKDILTKSNFHP HGIKVRLEDGRIGRDQQIVST*" /label="ywbE CDS" gene 3552847..3553044 /gene="ywbE" /locus_tag="BSU_38350" /old_locus_tag="BSU38350" /label="ywbE gene" downshifts 3553023 /Source="Nicolas_upshifts" /id="D1984" /incds=0 /nref=15 /ntot=205 /MaxReadThrough="1.90583" /MaxDrop="4.20528" /score="21.8132292" /energy="-12.2" /TU="NA" /idTUdmin="U3016" /TUdmin=88 /isTUend="FALSE" /label="downshifts" CDS complement(3553079..3554269) /gene="rlmI" /locus_tag="BSU_38360" /old_locus_tag="BSU38360" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 18786544, 18789337; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="large subunit ribosomal RNA m5C1962 methyltransferase" /protein_id="NP_391715.1" /db_xref="EnsemblGenomes-Gn:BSU38360" /db_xref="EnsemblGenomes-Tr:CAB15862" /db_xref="GOA:P39587" /db_xref="InterPro:IPR002478" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR019614" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR036974" /db_xref="SubtiList:BG10565" /db_xref="UniProtKB/Swiss-Prot:P39587" /translation="MKLLTLKKAHAAKIKKGYPLIEKEALAGSAGHMKEGDLVDIVSE SGGEFLARGYYGLQNKGVGWTLTRNKHEQIDQAFFLSKLTKAAQARAKLFEAQDTTAF RLFNGEGDGVGGVTIDYYDGYLLIQWYSKGIYTFKDMLISALDEMDLDYKAIYEKKRF DTAGQYVEDDDFVKGRRGEFPIIIQENGIQYAVDLNEGAMTGIFLDQRHVRKAIRDRY AKGKTVLNTFSYTGAFSVAAALGGAEKTTSVDVANRSLAKTIEQFSVNKLDYEAHDIK VMDVFNYFSYAAKKDLRFDLIILDPPSFARTKKRTFSAAKDYKNLLKETIAITADKGV IVASTNSSAFGMKKFKGFIDAAFKETNERYTIIEEFTLPEDFKTISAFPEGNYLKVVL LQKK*" /label="rlmI CDS" gene complement(3553079..3554269) /gene="rlmI" /locus_tag="BSU_38360" /old_locus_tag="BSU38360" /label="rlmI gene" downshifts complement(3553094) /Source="Nicolas_upshifts" /id="D1985" /incds=0 /nref=5 /ntot=127 /MaxReadThrough="0.0525399999999996" /MaxDrop="4.51664" /score="48.4884619" /energy="-14.3" /TU="NA" /idTUdmin="U3017" /TUdmin=71 /isTUend="FALSE" /label="downshifts" downshifts complement(3553178) /Source="Nicolas_upshifts" /id="D1986" /incds=1 /nref=42 /ntot=233 /MaxReadThrough="2.99734" /MaxDrop="3.89369" /score="48.4884619" /energy="-14.3" /TU="NA" /idTUdmin="U3017" /TUdmin="-13" /isTUend="TRUE" /label="downshifts" misc_feature complement(3554293..3554312) /Source="Nicolas_upshift_promotors" /id="U3017" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.738261738261738" /psig=1 /xcortree=1883 /SigmaFactorBS="tttttgtctatcgtagaaaaacctttcctttctgtcaatgca gacatcttggcgtttTGTGGTACCATAAGAGAAAGcaaacggaaagaggacgacatat a" /listShort="ywbD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3554309) /Source="Nicolas_upshifts" /id="U3017" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.738261738261738" /psig=1 /xcortree=1883 /SigmaFactorBS="tttttgtctatcgtagaaaaacctttcctttctgtcaatgca gacatcttggcgtttTGTGGTACCATAAGAGAAAGcaaacggaaagaggacgacatat a" /listShort="ywbD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3554329..3554336 /Source="Nicolas_upshift_promotors" /id="U3018" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.517482517482518" /psig=1 /xcortree=1984 /SigmaFactorBS="tccgtttgctttctcttatggtaccacaaaacgccaagatgt ctGCATTGACagaaaggaaaggtTTTTCTACGATAGACAAAAAgagttacgaggagga g" /listShort="ywbC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3554345 /Source="Nicolas_upshifts" /id="U3018" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.517482517482518" /psig=1 /xcortree=1984 /SigmaFactorBS="tccgtttgctttctcttatggtaccacaaaacgccaagatgt ctGCATTGACagaaaggaaaggtTTTTCTACGATAGACAAAAAgagttacgaggagga g" /listShort="ywbC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3554350..3554369 /Source="Nicolas_upshift_promotors" /id="U3018" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.517482517482518" /psig=1 /xcortree=1984 /SigmaFactorBS="tccgtttgctttctcttatggtaccacaaaacgccaagatgt ctGCATTGACagaaaggaaaggtTTTTCTACGATAGACAAAAAgagttacgaggagga g" /listShort="ywbC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3554390..3554770 /gene="glxA" /locus_tag="BSU_38370" /old_locus_tag="BSU38370" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:24330391, 25283443" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 24330391, 25283443; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glyoxalase I; hemithioacetal-bacillithiol lactoyl-bacillithiol formation" /protein_id="NP_391716.1" /db_xref="EnsemblGenomes-Gn:BSU38370" /db_xref="EnsemblGenomes-Tr:CAB15863" /db_xref="GOA:P39586" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR018146" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG10564" /db_xref="UniProtKB/Swiss-Prot:P39586" /translation="MAKRIDHTGIMVRDINASITFYEEVLGMKLKDRITHTNGVIELA FLGFEDGPETEIELIQGYSSELPAEGKVHHIALLTDDIAAEYTKAEKMNAKFIDEEIT TLPNGYRYFYIEGPDGEWIEFFQR*" /label="glxA CDS" gene 3554390..3554770 /gene="glxA" /locus_tag="BSU_38370" /old_locus_tag="BSU38370" /label="glxA gene" downshifts 3554668 /Source="Nicolas_upshifts" /id="D1987" /incds=1 /nref=14 /ntot=215 /MaxReadThrough="3.76076" /MaxDrop="3.68951" /score="-8.22053631" /energy="-7.4" /TU="U3018" /idTUdmin="U3018" /TUdmin="-357" /isTUend="FALSE" /label="downshifts" downshifts 3554739 /Source="Nicolas_upshifts" /id="D1988" /incds=0 /nref=1 /ntot=66 /MaxReadThrough="3.05249" /MaxDrop="3.56101" /score="-8.22053631" /energy="-7.4" /TU="U3018" /idTUdmin="U3018" /TUdmin="-286" /isTUend="FALSE" /label="downshifts" CDS complement(3554808..3555485) /gene="ywbB" /locus_tag="BSU_38380" /old_locus_tag="BSU38380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391717.1" /db_xref="EnsemblGenomes-Gn:BSU38380" /db_xref="EnsemblGenomes-Tr:CAB15864" /db_xref="InterPro:IPR024250" /db_xref="SubtiList:BG10563" /db_xref="UniProtKB/Swiss-Prot:P39585" /translation="MLDYIWLDDESPILQQVPVEYSSAALIFSPFIQMPEGWENAKRK NDYEHIYPNDNEIRGIGKAVSWKKVMSSCGFQTHAELALALMTSIGALRDEFAREDLA EVLHENINGDLYYPSEDHISNFHIPSLVKVLGANGSNRFYYAEPIVENRGVLDITEAN LRTVLDEAATELVLTDEKMDFVFMSVYDSFINVFLAKDKNIHELVERMGWEAMICDES TYISWYR*" /label="ywbB CDS" gene complement(3554808..3555485) /gene="ywbB" /locus_tag="BSU_38380" /old_locus_tag="BSU38380" /label="ywbB gene" downshifts complement(3554815) /Source="Nicolas_upshifts" /id="D1989" /incds=0 /nref=6 /ntot=156 /MaxReadThrough="0.15283" /MaxDrop="5.41362" /score="0.491291944" /energy="-11.7" /TU="NA" /idTUdmin="U3020" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3555494..3555513) /Source="Nicolas_upshift_promotors" /id="U3019" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig="0.997002997002997" /xcortree=2178 /SigmaFactorBS="gataaaaatgtgatgtgatagatgatcagcctgtcatagggc tgatcaTCTCTTTcaaacgaaaggAATGTTAGAATATGTAAAGGaggtgcgcatgcta g" /listShort="ywbB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3555519) /Source="Nicolas_upshifts" /id="U3019" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig="0.997002997002997" /xcortree=2178 /SigmaFactorBS="gataaaaatgtgatgtgatagatgatcagcctgtcatagggc tgatcaTCTCTTTcaaacgaaaggAATGTTAGAATATGTAAAGGaggtgcgcatgcta g" /listShort="ywbB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3555525..3555531) /Source="Nicolas_upshift_promotors" /id="U3019" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig="0.997002997002997" /xcortree=2178 /SigmaFactorBS="gataaaaatgtgatgtgatagatgatcagcctgtcatagggc tgatcaTCTCTTTcaaacgaaaggAATGTTAGAATATGTAAAGGaggtgcgcatgcta g" /listShort="ywbB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3555562..3556896) /gene="ywbA" /locus_tag="BSU_38390" /old_locus_tag="BSU38390" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8990303, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative cellobiose phosphotransferase system enzyme IIC permease component" /protein_id="NP_391718.1" /db_xref="EnsemblGenomes-Gn:BSU38390" /db_xref="EnsemblGenomes-Tr:CAB15865" /db_xref="GOA:P39584" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR004501" /db_xref="InterPro:IPR004796" /db_xref="SubtiList:BG10562" /db_xref="UniProtKB/Swiss-Prot:P39584" /translation="MSTFTRVMEEKIMPVAGKIAGQRHLSALRDGIILTMPLIIIGSV FLILTSLPIPGYADFMASVFGNEWADKLGYPVNASFDIMAMIAAFGIAYRLAESYGVD ALSAGAISIAAFLLATPFEVPFTPHGSTESIMVGGGIPITLLGSKGLFVAMLIALFST EIYRYIIQKNIVFKMPDGVPPAVSKSFVALIPGFIIVLLVWLARLLIEMTPFQSLHNV VGDLLGTPLSILGGSLGGSLIAEFVQMLLWSCGIHGASIIGGIMAPIWYGAMDANRLA FQAGEALPSIFTTQFFQIWINVGGSGATLALVLTMLVRSRSKQMKQLGRLGIGPALFN INEPIIFGMPIVMNPLLIVPFIIAPLLTITATYIGMSTGLVARPAGIAVPWTMPPLIS GYLATGGKVSGAVMQLVNLLITCAIYYPFFRIWDHQKWREESAVESGDKNVM*" /label="ywbA CDS" gene complement(3555562..3556896) /gene="ywbA" /locus_tag="BSU_38390" /old_locus_tag="BSU38390" /label="ywbA gene" misc_feature complement(3556944..3556962) /Source="Nicolas_upshift_promotors" /id="U3020" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.596403596403596" /psig="0.596403596403596" /xcortree=1254 /SigmaFactorBS="tttagcaaaatgcagattttttccgcatgaagaggaaatttt ccaaatgaatttgtaagcgttttCAAAATAAGATAAAGAAAAcattgcggaggttgtt c" /listShort="ywbA, ywbB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3556967) /Source="Nicolas_upshifts" /id="U3020" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.596403596403596" /psig="0.596403596403596" /xcortree=1254 /SigmaFactorBS="tttagcaaaatgcagattttttccgcatgaagaggaaatttt ccaaatgaatttgtaagcgttttCAAAATAAGATAAAGAAAAcattgcggaggttgtt c" /listShort="ywbA, ywbB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3557061..3557068 /Source="Nicolas_upshift_promotors" /id="U3021" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=2809 /SigmaFactorBS="ctgcattttgctaaacaaccctgcccatgaaaaattttttcc ttcttaCTATTAATctctctttttttcTCCGATATATATATCAAACatcatagaaaaa g" /listShort="epr" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3557073 /Source="Nicolas_upshifts" /id="U3021" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=2809 /SigmaFactorBS="ctgcattttgctaaacaaccctgcccatgaaaaattttttcc ttcttaCTATTAATctctctttttttcTCCGATATATATATCAAACatcatagaaaaa g" /listShort="epr" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3557082..3557100 /Source="Nicolas_upshift_promotors" /id="U3021" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=2809 /SigmaFactorBS="ctgcattttgctaaacaaccctgcccatgaaaaattttttcc ttcttaCTATTAATctctctttttttcTCCGATATATATATCAAACatcatagaaaaa g" /listShort="epr" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3557124..3559061 /gene="epr" /locus_tag="BSU_38400" /old_locus_tag="BSU38400" /EC_number="3.4.21.-" /function="16.11: Scavenge (Catabolism)" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1938892, 2116590, 16553828, 17666034, 19416356, 23660663, 25966269" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1938892, 2116590, 16553828, 17666034, 19416356, 23660663, 25966269; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="extracellular serine protease" /protein_id="NP_391719.1" /db_xref="EnsemblGenomes-Gn:BSU38400" /db_xref="EnsemblGenomes-Tr:CAB15866" /db_xref="GOA:P16396" /db_xref="InterPro:IPR000209" /db_xref="InterPro:IPR009020" /db_xref="InterPro:IPR015500" /db_xref="InterPro:IPR022398" /db_xref="InterPro:IPR023827" /db_xref="InterPro:IPR023828" /db_xref="InterPro:IPR034202" /db_xref="InterPro:IPR036852" /db_xref="InterPro:IPR037045" /db_xref="SubtiList:BG10561" /db_xref="UniProtKB/Swiss-Prot:P16396" /translation="MKNMSCKLVVSVTLFFSFLTIGPLAHAQNSSEKEVIVVYKNKAG KETILDSDADVEQQYKHLPAVAVTADQETVKELKQDPDILYVENNVSFTAADSTDFKV LSDGTDTSDNFEQWNLEPIQVKQAWKAGLTGKNIKIAVIDSGISPHDDLSIAGGYSAV SYTSSYKDDNGHGTHVAGIIGAKHNGYGIDGIAPEAQIYAVKALDQNGSGDLQSLLQG IDWSIANRMDIVNMSLGTTSDSKILHDAVNKAYEQGVLLVAASGNDGNGKPVNYPAAY SSVVAVSATNEKNQLASFSTTGDEVEFSAPGTNITSTYLNQYYATGSGTSQATPHAAA MFALLKQRDPAETNVQLREEMRKNIVDLGTAGRDQQFGYGLIQYKAQATDSAYAAAEQ AVKKAEQTKAQIDINKARELISQLPNSDAKTALHKRLDKVQSYRNVKDAKDKVAKAEK YKTQQTVDTAQTAINKLPNGTDKKNLQKRLDQVKRYIASKQAKDKVAKAEKSKKKTDV DSAQSAIGKLPASSEKTSLQKRLNKVKSTNLKTAQQSVSAAEKKSTDANAAKAQSAVN QLQAGKDKTALQKRLDKVKKKVAAAEAKKVETAKAKVKKAEKDKTKKSKTSAQSAVNQ LKASNEKTKLQKRLNAVKPKK*" /label="epr CDS" gene 3557124..3559061 /gene="epr" /locus_tag="BSU_38400" /old_locus_tag="BSU38400" /label="epr gene" promotor_-10 complement(3558268..3558287) /Source="Nicolas_upshift_promotors" /id="U3022" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.81018981018981" /psig="0.81018981018981" /xcortree=1236 /SigmaFactorBS="tgcttttgtttgttccgcttTTTTCACCGcttgctctgctgc CGCGTACGCTGAATCTGTTGcctgtgctttatactggattaagccgtagccaaattgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3558269) /Source="Nicolas_upshifts" /id="U3022" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.81018981018981" /psig="0.81018981018981" /xcortree=1236 /SigmaFactorBS="tgcttttgtttgttccgcttTTTTCACCGcttgctctgctgc CGCGTACGCTGAATCTGTTGcctgtgctttatactggattaagccgtagccaaattgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3558301..3558309) /Source="Nicolas_upshift_promotors" /id="U3022" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.81018981018981" /psig="0.81018981018981" /xcortree=1236 /SigmaFactorBS="tgcttttgtttgttccgcttTTTTCACCGcttgctctgctgc CGCGTACGCTGAATCTGTTGcctgtgctttatactggattaagccgtagccaaattgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3559051 /Source="Nicolas_upshifts" /id="D1990" /incds=0 /nref=175 /ntot=224 /MaxReadThrough="1.26567" /MaxDrop="6.00181" /score="15.6173594" /energy="-13" /TU="NA" /idTUdmin="U3021" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 3559164..3559171 /Source="Nicolas_upshift_promotors" /id="U3023" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.813186813186813" /psig="0.99000999000999" /xcortree=1754 /SigmaFactorBS="ttgtacaggcttttcatacTATTGCTAtacagccatgaacaG CATAAAATGAACGTTATTAcagttatcaccacatatggcgggattgtgactgggcagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3559186..3559205 /Source="Nicolas_upshift_promotors" /id="U3023" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.813186813186813" /psig="0.99000999000999" /xcortree=1754 /SigmaFactorBS="ttgtacaggcttttcatacTATTGCTAtacagccatgaacaG CATAAAATGAACGTTATTAcagttatcaccacatatggcgggattgtgactgggcagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3559205 /Source="Nicolas_upshifts" /id="U3023" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.813186813186813" /psig="0.99000999000999" /xcortree=1754 /SigmaFactorBS="ttgtacaggcttttcatacTATTGCTAtacagccatgaacaG CATAAAATGAACGTTATTAcagttatcaccacatatggcgggattgtgactgggcagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3559417..3559424 /Source="Nicolas_upshift_promotors" /id="U3024" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.447552447552448" /psig="0.996003996003996" /xcortree=2192 /SigmaFactorBS="catttttgtcattttcagccggtatttctcacttttttcaTT TTGATTgtcaacttttcaTTTGATACGATGAACAAGCCgacttttcttcagcaaagga g" /listShort="sacX, sacY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3559437..3559456 /Source="Nicolas_upshift_promotors" /id="U3024" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.447552447552448" /psig="0.996003996003996" /xcortree=2192 /SigmaFactorBS="catttttgtcattttcagccggtatttctcacttttttcaTT TTGATTgtcaacttttcaTTTGATACGATGAACAAGCCgacttttcttcagcaaagga g" /listShort="sacX, sacY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3559437 /Source="Nicolas_upshifts" /id="U3024" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.447552447552448" /psig="0.996003996003996" /xcortree=2192 /SigmaFactorBS="catttttgtcattttcagccggtatttctcacttttttcaTT TTGATTgtcaacttttcaTTTGATACGATGAACAAGCCgacttttcttcagcaaagga g" /listShort="sacX, sacY" /GFF_Attribute="listLong" /label="upshifts" CDS 3559489..3560868 /gene="sacX" /locus_tag="BSU_38410" /old_locus_tag="BSU38410" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11580842, 1400159, 8535520, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11580842, 1400159, 8535520, 15849754, 16850406; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of SacY" /protein_id="NP_391720.1" /db_xref="EnsemblGenomes-Gn:BSU38410" /db_xref="EnsemblGenomes-Tr:CAB15867" /db_xref="GOA:P15400" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR010973" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG10560" /db_xref="UniProtKB/Swiss-Prot:P15400" /translation="MHKEIAKELLLLAGGKNNIISISHCTTRLRFDVKDETKIDIHAI ENLQGVQGTFFRYGLFQIIFGAGVVNKIYKEVVHVWETAPSEEPVHQKKASRKLNPAA AFAKTLSDIFVPIIPAITASGLLMGLIGMIKVFHWFAAGSPWIKMLDLVSSTAFILLP ILVGFSAARQFGSNPYLGAVIAGLLTHPDLLDPSMLGSKTPSSLDIWGLHIPMMGYQG SMIPILLSVFVMSKIEKLLKSIVPKSLDVVIIPFITVMVTGCLALIVMNPAASIIGQI MTQSIVYIYDHAGIAAGALFGGIYSTIVLSGLHHSFYAIEATLLANPHVGVNFLVPIW SMANVAQGGAGLAVFLKTKQSSLKKIALPASLTAFLGIVEPIVFGVNLKLIRPFIGAA IGGAIGGAYVVAVQVVANSYGLTGIPMISIVLPFGAANFVHYMIGFLIAAVSAFIATL FLGFKEETE*" /label="sacX CDS" gene 3559489..3560868 /gene="sacX" /locus_tag="BSU_38410" /old_locus_tag="BSU38410" /label="sacX gene" S_feature complement(3560577..3561780) /Source="Nicolas_S_feature" /locus_tag="new_3943322_3944525_c" /HighExp="Etha, B36, B60, M9-stat, Salt, Sw, LoTm, C30, Gly, Heat" /AntisenseName="sacY" /AntisenseCor="-0.177403958488455" /AntisenseRegPval="-2.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1477" CDS 3560922..3561764 /gene="sacY" /locus_tag="BSU_38420" /old_locus_tag="BSU38420" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9305644, 9457872, 11580842, 12079345, 15528654, 21278164" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9305644, 9457872, 11580842, 12079345, 15528654, 21278164; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional antiterminator" /protein_id="NP_391721.1" /db_xref="EnsemblGenomes-Gn:BSU38420" /db_xref="EnsemblGenomes-Tr:CAB15868" /db_xref="GOA:P15401" /db_xref="InterPro:IPR001550" /db_xref="InterPro:IPR004341" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR036634" /db_xref="InterPro:IPR036650" /db_xref="PDB:1AUU" /db_xref="SubtiList:BG10559" /db_xref="UniProtKB/Swiss-Prot:P15401" /translation="MKIKRILNHNAIVVKDQNEEKILLGAGIAFNKKKNDIVDPSKIE KTFIRKDTPDYKQFEEILETLPEDHIQISEQIISHAEKELNIKINERIHVAFSDHLSF AIERLSNGMVIKNPLLNEIKVLYPKEFQIGLWARALIKDKLGIHIPDDEIGNIAMHIH TARNNAGDMTQTLDITTMIRDIIEIIEIQLSINIVEDTISYERLVTHLRFAIQHIKAG ESIYELDAEMIDIIKEKFKDAFLCALSIGTFVKKEYGFEFPEKELCYIAMHIQRFYQR SVAR*" /label="sacY CDS" gene 3560922..3561764 /gene="sacY" /locus_tag="BSU_38420" /old_locus_tag="BSU38420" /label="sacY gene" CDS complement(3561815..3562675) /gene="gspA" /locus_tag="BSU_38430" /old_locus_tag="BSU38430" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11377871, 19659723; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyl transferase (general stress protein)" /protein_id="NP_391722.1" /db_xref="EnsemblGenomes-Gn:BSU38430" /db_xref="EnsemblGenomes-Tr:CAB15869" /db_xref="GOA:P25148" /db_xref="InterPro:IPR002495" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10558" /db_xref="UniProtKB/Swiss-Prot:P25148" /translation="MRKDEIMHIVSCADDNYARHLGGMFVSLLTNMDQEREVKLYVID GGIKPDNKKRLEETTLKFGVPIEFLEVDTNMYEHAVESSHITKAAYYRISIPDLIKDE SIKRMIYIDCDALVLEDISKLWDLDIAPYTVAAVEDAGQHERLKEMNVTDTGKYFNSG IMIIDFESWRKQNITEKVINFINEHPDEDFLVLHDQDALNAILYDQWYELHPRWNAQT YIMLKLKTPSTLLGRKQYNETRENPAIVHFCGGEKPWNSNTKHPYRDEYFHYMSYTKW NTIGNPAINQ*" /label="gspA CDS" gene complement(3561815..3562675) /gene="gspA" /locus_tag="BSU_38430" /old_locus_tag="BSU38430" /label="gspA gene" downshifts complement(3561825) /Source="Nicolas_upshifts" /id="D1991" /incds=0 /nref=73 /ntot=227 /MaxReadThrough="5.61926" /MaxDrop="7.47527" /score="21.8603429" /energy="-10.6" /TU="U3025" /idTUdmin="U3025" /TUdmin="-1224" /isTUend="FALSE" /label="downshifts" downshifts 3562659 /Source="Nicolas_upshifts" /id="D1992" /incds=0 /nref=8 /ntot=30 /MaxReadThrough="1.49599" /MaxDrop="5.33818" /score="10.6843241" /energy="-4.5" /TU="NA" /idTUdmin="U3026" /TUdmin="-528" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3562697..3562715) /Source="Nicolas_upshift_promotors" /id="U3025" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=226 /SigmaFactorBS="tgttgtatcacacattctgtttaaaaaaatgtcggagaaCGT GTTTatttttttgaaaaaGGGTATGTAACTTGTACAAcaaaaagggagatgaatacca t" /listShort="gspA, S1477" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3562715) /Source="Nicolas_upshifts" /id="U3025" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=226 /SigmaFactorBS="tgttgtatcacacattctgtttaaaaaaatgtcggagaaCGT GTTTatttttttgaaaaaGGGTATGTAACTTGTACAAcaaaaagggagatgaatacca t" /listShort="gspA, S1477" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3562730..3562736) /Source="Nicolas_upshift_promotors" /id="U3025" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=226 /SigmaFactorBS="tgttgtatcacacattctgtttaaaaaaatgtcggagaaCGT GTTTatttttttgaaaaaGGGTATGTAACTTGTACAAcaaaaagggagatgaatacca t" /listShort="gspA, S1477" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3562785..3563498) /gene="ywaF" /locus_tag="BSU_38440" /old_locus_tag="BSU38440" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein of unknown function" /protein_id="NP_391723.1" /db_xref="EnsemblGenomes-Gn:BSU38440" /db_xref="EnsemblGenomes-Tr:CAB15870" /db_xref="GOA:P25149" /db_xref="InterPro:IPR011737" /db_xref="SubtiList:BG10557" /db_xref="UniProtKB/Swiss-Prot:P25149" /translation="MQKYVQSDYKHDPFHLFSTEHVVTLAIISLLAILLFLFQDEVKQ PRASRFLRSLFVFLLLGSQIGYQIWMVATDRWSVRTSLPLQLSDLSVYLSAIMLVTKS RKLFVFLFFVGIGSSIQALATPDLGMFSFPHIRYILFFISHGSVFLSCLLMAVIGTYR MGQRSLWVTVLLVNVYGVCIFLIDRWLGANYMYLTKKPGGSSLLDVLGPWPWYIVSAE AITIASFFILYWLYRIFKK*" /label="ywaF CDS" gene complement(3562785..3563498) /gene="ywaF" /locus_tag="BSU_38440" /old_locus_tag="BSU38440" /label="ywaF gene" promotor_-35 3562900..3562901 /Source="Nicolas_upshift_promotors" /id="U3026" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.275724275724276" /psig="0.275724275724276" /xcortree=93 /SigmaFactorBS="ccacggccatggcccgagaacatctaagagagaggaaCCgcc cggttttttcgtcaaaTACATATAATTCGCGCCAagccagcgatcaatcagaaaaata c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3562921..3562938 /Source="Nicolas_upshift_promotors" /id="U3026" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.275724275724276" /psig="0.275724275724276" /xcortree=93 /SigmaFactorBS="ccacggccatggcccgagaacatctaagagagaggaaCCgcc cggttttttcgtcaaaTACATATAATTCGCGCCAagccagcgatcaatcagaaaaata c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3562923 /Source="Nicolas_upshifts" /id="U3026" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.275724275724276" /psig="0.275724275724276" /xcortree=93 /SigmaFactorBS="ccacggccatggcccgagaacatctaagagagaggaaCCgcc cggttttttcgtcaaaTACATATAATTCGCGCCAagccagcgatcaatcagaaaaata c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3563526..3563537) /Source="Nicolas_upshift_promotors" /id="U3027" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=818 /SigmaFactorBS="ggtgtgaacttcaagcccatatatcggttGAATAAAaaaagc ccaaacaaCGCCAAAATAAAcaaaaacccgaaaacgggggtgcagttttgcaaaaata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3563527) /Source="Nicolas_upshifts" /id="U3027" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=818 /SigmaFactorBS="ggtgtgaacttcaagcccatatatcggttGAATAAAaaaagc ccaaacaaCGCCAAAATAAAcaaaaacccgaaaacgggggtgcagttttgcaaaaata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3563552..3563558) /Source="Nicolas_upshift_promotors" /id="U3027" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=818 /SigmaFactorBS="ggtgtgaacttcaagcccatatatcggttGAATAAAaaaagc ccaaacaaCGCCAAAATAAAcaaaaacccgaaaacgggggtgcagttttgcaaaaata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3563573..3563579 /Source="Nicolas_upshift_promotors" /id="U3028" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.462537462537463" /psig="0.842157842157842" /xcortree=659 /SigmaFactorBS="gggctttttttattcaaccgatatatgggCTTGAAGttcaca ccagactcTGTTAAAATTCGTTTCATAGctaatgattctgataatttaaggcaggcct a" /listShort="ywaE, NA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3563594..3563613 /Source="Nicolas_upshift_promotors" /id="U3028" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.462537462537463" /psig="0.842157842157842" /xcortree=659 /SigmaFactorBS="gggctttttttattcaaccgatatatgggCTTGAAGttcaca ccagactcTGTTAAAATTCGTTTCATAGctaatgattctgataatttaaggcaggcct a" /listShort="ywaE, NA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3563604 /Source="Nicolas_upshifts" /id="U3028" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.462537462537463" /psig="0.842157842157842" /xcortree=659 /SigmaFactorBS="gggctttttttattcaaccgatatatgggCTTGAAGttcaca ccagactcTGTTAAAATTCGTTTCATAGctaatgattctgataatttaaggcaggcct a" /listShort="ywaE, NA" /GFF_Attribute="listLong" /label="upshifts" CDS 3563649..3564164 /gene="tyrZR" /locus_tag="BSU_38450" /old_locus_tag="BSU38450" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:25733610" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25733610; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator controlling expressionof tyrZ" /protein_id="NP_391724.1" /db_xref="EnsemblGenomes-Gn:BSU38450" /db_xref="EnsemblGenomes-Tr:CAB15871" /db_xref="GOA:P25150" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10556" /db_xref="UniProtKB/Swiss-Prot:P25150" /translation="MERSHQHQQLRKEEHDTLSKLKQMPVESLNLEAISIATNLYRSA QRLRVKMETEVLSTYNLSWTAFSILYDLWVWGALETRKIAELSGISTATASNVIKTLE KKSFCRKSIDTRDRRLVFVSITDSGKQAIEELYPEFHKGETELIAGMTKDEQKILTGL LRKVADNLHTT*" /label="tyrZR CDS" gene 3563649..3564164 /gene="tyrZR" /locus_tag="BSU_38450" /old_locus_tag="BSU38450" /label="tyrZR gene" misc_RNA 3564165..3564371 /gene="tboYB" /locus_tag="BSU_misc_RNA_59" /product="T-box riboswitch specific of tyrosine tRNA ligase" /experiment="publication(s) with functional evidences, PMID:8045882, 9098041, 10943892, 11842119, 12165569, 12547201, 1317842" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045882, 9098041, 10943892, 11842119, 12165569, 12547201, 1317842; Product type n: RNA" /function="16.3: Control" /label="tboYB RNA" gene 3564165..3564371 /gene="tboYB" /locus_tag="BSU_misc_RNA_59" /label="tboYB gene" downshifts 3564331 /Source="Nicolas_upshifts" /id="D1993" /incds=0 /nref=15 /ntot=112 /MaxReadThrough="1.84575" /MaxDrop="4.56656" /score="23.8000948" /energy="-14.5" /TU="NA" /idTUdmin="U3028" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 3564413..3565654 /gene="tyrZ" /locus_tag="BSU_38460" /old_locus_tag="BSU38460" /EC_number="6.1.1.1" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1735721, 1806041, 25733610" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1735721, 1806041, 25733610; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tyrosyl-tRNA synthetase" /protein_id="NP_391725.1" /db_xref="EnsemblGenomes-Gn:BSU38460" /db_xref="EnsemblGenomes-Tr:CAB15872" /db_xref="GOA:P25151" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR002305" /db_xref="InterPro:IPR002307" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR024088" /db_xref="InterPro:IPR024108" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG10555" /db_xref="UniProtKB/Swiss-Prot:P25151" /translation="MMRTFEQLTASQQKEVERQLQLYMTGAHEVIPPEELKAKLVKSI STGTPLKIKLGLDPSAPDVHLGHTVVLNKLRQFQENGHIVQLLIGDFTGKIGDPTGKS AARKQLTDEEVQHNAKTYFEQFGKVLDPEKVELHYNSKWLKTLNLEDVIELAGKITVA RLMERDDFEERIAMQKPISLHEFFYPLMQGYDSVVLESDIELGGTDQHFNVLMGRHFQ ERYNKEKQVVILMPLLEGLDGVEKMSKSKHNYIGINEHPNDMYGKTMSLPDSLMKKYI HLATDLELEEKKQLVKDLETGAVHPRDAKMLLARTIVRMYHGEKAAEAAEHSFKTVFQ ENSLPEDIPAVNWKGEKTIAMIDLLVKLKLLSSKSEARRMIQNGGVRIDGEKVTDVHA KAEIRENMIIQVGKRKFLKLQ*" /label="tyrZ CDS" gene 3564413..3565654 /gene="tyrZ" /locus_tag="BSU_38460" /old_locus_tag="BSU38460" /label="tyrZ gene" promotor_-35 3565745..3565753 /Source="Nicolas_upshift_promotors" /id="U3029" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=502 /SigmaFactorBS="cactgtcttttcaaaaacgctctccatcttGCAGGAAACtcc tttagcaTCCCGAAATATTCCCCAACcatacatttaggggaggtttatttttgatgaa a" /listShort="ywaD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3565764..3565782 /Source="Nicolas_upshift_promotors" /id="U3029" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=502 /SigmaFactorBS="cactgtcttttcaaaaacgctctccatcttGCAGGAAACtcc tttagcaTCCCGAAATATTCCCCAACcatacatttaggggaggtttatttttgatgaa a" /listShort="ywaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3565775 /Source="Nicolas_upshifts" /id="U3029" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=502 /SigmaFactorBS="cactgtcttttcaaaaacgctctccatcttGCAGGAAACtcc tttagcaTCCCGAAATATTCCCCAACcatacatttaggggaggtttatttttgatgaa a" /listShort="ywaD" /GFF_Attribute="listLong" /label="upshifts" CDS 3565810..3567177 /gene="eapD" /locus_tag="BSU_38470" /old_locus_tag="BSU38470" /EC_number="3.4.11.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15668014, 23426795, 26898926, 28257579" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15668014, 23426795, 26898926, 28257579; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported double-zinc aminopeptidase" /protein_id="NP_391726.1" /db_xref="EnsemblGenomes-Gn:BSU38470" /db_xref="EnsemblGenomes-Tr:CAB15873" /db_xref="GOA:P25152" /db_xref="InterPro:IPR003137" /db_xref="InterPro:IPR007484" /db_xref="SubtiList:BG10554" /db_xref="UniProtKB/Swiss-Prot:P25152" /translation="MKKLLTVMTMAVLTAGTLLLPAQSVTPAAHAVQISNSERELPFK AKHAYSTISQLSEAIGPRIAGTAAEKKSALLIASSMRKLKLDVKVQRFNIPDRLEGTL SSAGRDILLQAASGSAPTEEQGLTAPLYNAGLGYQKDFTADAKGKIALISRGDLTYYE KAKNAEAAGAKAVIIYNNKESLVPMTPNLSGNKVGIPVVGIKKEDGEALTQQKEATLK LKAFTNQTSQNIIGIKKPKNIKHPDIVYVTAHYDSVPFSPGANDNGSGTSVMLEMARV LKSVPSDKEIRFIAFGAEELGLLGSSHYVDHLSEKELKRSEVNFNLDMVGTSWEKASE LYVNTLDGQSNYVWESSRTAAEKIGFDSLSLTQGGSSDHVPFHEAGIDSANFIWGDPE TEEVEPWYHTPEDSIEHISKERLQQAGDLVTAAVYEAVKKEKKPKTIKKQMKAKASDI FEDIK*" /label="eapD CDS" gene 3565810..3567177 /gene="eapD" /locus_tag="BSU_38470" /old_locus_tag="BSU38470" /label="eapD gene" downshifts 3567154 /Source="Nicolas_upshifts" /id="D1994" /incds=0 /nref=3 /ntot=37 /MaxReadThrough="1.38814" /MaxDrop="6.05871" /score="27.7635079" /energy="-13.3" /TU="NA" /idTUdmin="U3029" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS complement(3567207..3567839) /gene="relQ" /locus_tag="BSU_38480" /old_locus_tag="BSU38480" /EC_number="2.7.6.5" /function="16.7: Manage energy" /function="16.3: Control" /function="16.14: Store" /experiment="publication(s) with functional evidences, PMID:17714452, 18067544, 19447912, 22333191, 22950019, 24163341, 25331430, 26211718" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17714452, 18067544, 19447912, 22333191, 22950019, 24163341, 25331430, 26211718; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="(p)ppGpp synthetase" /protein_id="NP_391727.1" /db_xref="EnsemblGenomes-Gn:BSU38480" /db_xref="EnsemblGenomes-Tr:CAB15874" /db_xref="GOA:P39583" /db_xref="InterPro:IPR007685" /db_xref="SubtiList:BG10553" /db_xref="UniProtKB/Swiss-Prot:P39583" /translation="MDLSVTHMDDLKTVMEDWKNELLVYKFALDALDTKFSIISQEYN LIHGHNPIEHTKSRVKSFESIVNKLMRKGCEITTKEMKEHIHDIAGVRIICSFISDIY NVVNVLKQHEDLRIVKVKDYIQTPKPNGYRSLHLIIEMPVNLTNRVEYVKAEIQIRTI AMDFWASLEHKIYYKLNNDVPKQLTDELKEAAEIAHYLDEKMLGIKKEVD*" /label="relQ CDS" gene complement(3567207..3567839) /gene="relQ" /locus_tag="BSU_38480" /old_locus_tag="BSU38480" /label="relQ gene" downshifts complement(3567225) /Source="Nicolas_upshifts" /id="D1995" /incds=0 /nref=200 /ntot=257 /MaxReadThrough="2.49976" /MaxDrop="5.49802" /score="47.236042" /energy="-13.3" /TU="NA" /idTUdmin="U3030" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3567875..3567890) /Source="Nicolas_upshift_promotors" /id="U3030" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1644 /SigmaFactorBS="tacaatcgaccgcattttgtaaaaaaattcatAGAACCTTGc agcagacagggACGTCTAGTACATGGAcagcggataaagttccgttaaaggagatgac g" /listShort="ywaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3567883) /Source="Nicolas_upshifts" /id="U3030" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1644 /SigmaFactorBS="tacaatcgaccgcattttgtaaaaaaattcatAGAACCTTGc agcagacagggACGTCTAGTACATGGAcagcggataaagttccgttaaaggagatgac g" /listShort="ywaC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3567903..3567911) /Source="Nicolas_upshift_promotors" /id="U3030" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1644 /SigmaFactorBS="tacaatcgaccgcattttgtaaaaaaattcatAGAACCTTGc agcagacagggACGTCTAGTACATGGAcagcggataaagttccgttaaaggagatgac g" /listShort="ywaC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3567981..3568916) /gene="menA" /locus_tag="BSU_38490" /old_locus_tag="BSU38490" /EC_number="2.5.1.74" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 6780514, 9573170, 12682299, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="1,4-dihydroxy-2-naphthoate octaprenyltransferase" /protein_id="NP_391728.1" /db_xref="EnsemblGenomes-Gn:BSU38490" /db_xref="EnsemblGenomes-Tr:CAB15875" /db_xref="GOA:P39582" /db_xref="InterPro:IPR000537" /db_xref="InterPro:IPR004657" /db_xref="InterPro:IPR026046" /db_xref="SubtiList:BG10552" /db_xref="UniProtKB/Swiss-Prot:P39582" /translation="MNQTNKGEGQTAPQKESMGQILWQLTRPHTLTASFVPVLLGTVL AMFYVKVDLLLFLAMLFSCLWIQIATNLFNEYYDFKRGLDTAESVGIGGAIVRHGMKP KTILQLALASYGIAILLGVYICASSSWWLALIGLVGMAIGYLYTGGPLPIAYTPFGEL FSGICMGSVFVLISFFIQTDKINMQSILISIPIAILVGAINLSNNIRDIEEDKKGGRK TLAILMGHKGAVTLLAASFAVAYIWVVGLVITGAASPWLFVVFLSVPKPVQAVKGFVQ NEMPMNMIVAMKSTAQTNTFFGFLLSIGLLISYFR*" /label="menA CDS" gene complement(3567981..3568916) /gene="menA" /locus_tag="BSU_38490" /old_locus_tag="BSU38490" /label="menA gene" downshifts complement(3567993) /Source="Nicolas_upshifts" /id="D1996" /incds=0 /nref=10 /ntot=113 /MaxReadThrough="3.08081" /MaxDrop="4.6874" /score="16.8971767" /energy="-8.5" /TU="NA" /idTUdmin="U3032" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 3568660..3568669 /Source="Nicolas_upshift_promotors" /id="U3031" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=1379 /SigmaFactorBS="cgtacaatggcccctccgattccgactgattctGCTGTATCT AatccgcgtttaaaATCATAGTATTCATTAAATAagttcgtcgcgatctggatccata g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3568683..3568702 /Source="Nicolas_upshift_promotors" /id="U3031" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=1379 /SigmaFactorBS="cgtacaatggcccctccgattccgactgattctGCTGTATCT AatccgcgtttaaaATCATAGTATTCATTAAATAagttcgtcgcgatctggatccata g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3568687 /Source="Nicolas_upshifts" /id="U3031" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=1379 /SigmaFactorBS="cgtacaatggcccctccgattccgactgattctGCTGTATCT AatccgcgtttaaaATCATAGTATTCATTAAATAagttcgtcgcgatctggatccata g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3568917..3569004) /Source="Nicolas_S_feature" /locus_tag="new_3951662_3951749_c" /HighExp="LBGstat, Paraq, G180, LBGexp, G135, Oxctl, C30, Cold, Diami, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.81271400000000005" /TUshortSig="SigA, Sig-" /TUshortPSig="0.999, 0.498" /TUlongSig="NA" /TUlongPSig="NA" /label="S1478" promotor_-10 complement(3568987..3569006) /Source="Nicolas_upshift_promotors" /id="U3032" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.801198801198801" /psig="0.999000999001" /xcortree=2514 /SigmaFactorBS="gaagcgtataataagaaagaaaacgccttcttgcggtaTCTT GtgaaataagggagaaGTCATTATGATAGATAAGGAagcaaaaggagttttttattaa g" /listShort="S1478, menA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3569004) /Source="Nicolas_upshifts" /id="U3032" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.801198801198801" /psig="0.999000999001" /xcortree=2514 /SigmaFactorBS="gaagcgtataataagaaagaaaacgccttcttgcggtaTCTT GtgaaataagggagaaGTCATTATGATAGATAAGGAagcaaaaggagttttttattaa g" /listShort="S1478, menA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3569022..3569026) /Source="Nicolas_upshift_promotors" /id="U3032" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.801198801198801" /psig="0.999000999001" /xcortree=2514 /SigmaFactorBS="gaagcgtataataagaaagaaaacgccttcttgcggtaTCTT GtgaaataagggagaaGTCATTATGATAGATAAGGAagcaaaaggagttttttattaa g" /listShort="S1478, menA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3569049..3569061) /Source="Nicolas_upshift_promotors" /id="U3033" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=2049 /SigmaFactorBS="cctgttcgttcaagtgaaagcagaaacCTAATGAaatcaggg cgagaaGCGTATAATAAGAaagaaaacgccttcttgcggtatcttgtgaaataaggga g" /listShort="S1478, menA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3569049) /Source="Nicolas_upshifts" /id="U3033" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=2049 /SigmaFactorBS="cctgttcgttcaagtgaaagcagaaacCTAATGAaatcaggg cgagaaGCGTATAATAAGAaagaaaacgccttcttgcggtatcttgtgaaataaggga g" /listShort="S1478, menA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3569076..3569082) /Source="Nicolas_upshift_promotors" /id="U3033" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=2049 /SigmaFactorBS="cctgttcgttcaagtgaaagcagaaacCTAATGAaatcaggg cgagaaGCGTATAATAAGAaagaaaacgccttcttgcggtatcttgtgaaataaggga g" /listShort="S1478, menA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3569079..3569213) /locus_tag="BSU_38495" /old_locus_tag="BSU38495" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514012.1" /translation="MECFELIHNKGKDTWSQKIFLTFKKCNVLKKIFLYLFVQVKAET *" /label="hypothetical protein CDS" gene complement(3569079..3569213) /locus_tag="BSU_38495" /old_locus_tag="BSU38495" /label="gene" promotor_-35 3569160..3569167 /Source="Nicolas_upshift_promotors" /id="U3034" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.884115884115884" /psig="0.998001998001998" /xcortree=2465 /SigmaFactorBS="tacattacactttttaaaagttaaaaagatCTTTTGACtcca ggtatctttTCCTTTATTATGAATCAGCTcgaaacattccattcttgcccttgcaggt a" /listShort="S1479" /listLong="ywzH, dltA, dltB, dltC, dltD, S1480, dltE, ilvK" /label="promotor_-35" promotor_-10 3569181..3569200 /Source="Nicolas_upshift_promotors" /id="U3034" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.884115884115884" /psig="0.998001998001998" /xcortree=2465 /SigmaFactorBS="tacattacactttttaaaagttaaaaagatCTTTTGACtcca ggtatctttTCCTTTATTATGAATCAGCTcgaaacattccattcttgcccttgcaggt a" /listShort="S1479" /listLong="ywzH, dltA, dltB, dltC, dltD, S1480, dltE, ilvK" /label="promotor_-10" upshifts 3569190 /Source="Nicolas_upshifts" /id="U3034" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.884115884115884" /psig="0.998001998001998" /xcortree=2465 /SigmaFactorBS="tacattacactttttaaaagttaaaaagatCTTTTGACtcca ggtatctttTCCTTTATTATGAATCAGCTcgaaacattccattcttgcccttgcaggt a" /listShort="S1479" /listLong="ywzH, dltA, dltB, dltC, dltD, S1480, dltE, ilvK" /label="upshifts" S_feature 3569193..3569297 /Source="Nicolas_S_feature" /locus_tag="new_3951938_3952042" /HighExp="H2O2, Paraq, Oxctl, G180, G150, C30, G135, LBGstat, dia15, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1479" promotor_-35 3569292..3569301 /Source="Nicolas_upshift_promotors" /id="U3035" /multdbtbs="SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2508 /SigmaFactorBS="cattttcaaaaacatacgccgatatattaatttgagggagat tagggaaaaaaTGAAACTTTTtgagcatctgaTCGTCAAATAATCATGtgattgtcga a" /listShort="ywzH, dltA, dltB, dltC, dltD, S1480, dltE, ilvK" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3569299 /Source="Nicolas_upshifts" /id="U3035" /multdbtbs="SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2508 /SigmaFactorBS="cattttcaaaaacatacgccgatatattaatttgagggagat tagggaaaaaaTGAAACTTTTtgagcatctgaTCGTCAAATAATCATGtgattgtcga a" /listShort="ywzH, dltA, dltB, dltC, dltD, S1480, dltE, ilvK" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3569313..3569328 /Source="Nicolas_upshift_promotors" /id="U3035" /multdbtbs="SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2508 /SigmaFactorBS="cattttcaaaaacatacgccgatatattaatttgagggagat tagggaaaaaaTGAAACTTTTtgagcatctgaTCGTCAAATAATCATGtgattgtcga a" /listShort="ywzH, dltA, dltB, dltC, dltD, S1480, dltE, ilvK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3569335) /Source="Nicolas_upshifts" /id="U3036" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.976023976023976" /psig="0.001998001998002" /xcortree=298 /SigmaFactorBS="tttttcatacagctgtttcattaattgcagcatatcaaaaat tcCCTTCCCGTTTTTTCgacaatcacatgattatttgacgatcagatgctcaaaaagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(3569337..3569351) /Source="Nicolas_upshift_promotors" /id="U3036" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.976023976023976" /psig="0.001998001998002" /xcortree=298 /SigmaFactorBS="tttttcatacagctgtttcattaattgcagcatatcaaaaat tcCCTTCCCGTTTTTTCgacaatcacatgattatttgacgatcagatgctcaaaaagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 3569363..3569512 /gene="ywzH" /locus_tag="BSU_38499" /old_locus_tag="BSU38499" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical membrane protein" /protein_id="YP_003097795.1" /db_xref="EnsemblGenomes-Gn:BSU38499" /db_xref="EnsemblGenomes-Tr:CAX52708" /db_xref="GOA:C0H3T3" /db_xref="InterPro:IPR021008" /db_xref="UniProtKB/Swiss-Prot:C0H3T3" /translation="MLQLMKQLYEKPAVKWTCHTGFYLMILLVLFFMYGFHTANTGSY IYNDF*" /label="ywzH CDS" gene 3569363..3569512 /gene="ywzH" /locus_tag="BSU_38499" /old_locus_tag="BSU38499" /label="ywzH gene" CDS 3569530..3571041 /gene="dltA" /locus_tag="BSU_38500" /old_locus_tag="BSU38500" /EC_number="6.1.1.13" /function="16.8: Protect" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7797557, 11222605, 14665680, 15955059, 18847223, 19324056, 23858088" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7797557, 11222605, 14665680, 15955059, 18847223, 19324056, 23858088; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanine:D-alanyl-carrier protein ligase subunit" /protein_id="NP_391729.1" /db_xref="EnsemblGenomes-Gn:BSU38500" /db_xref="EnsemblGenomes-Tr:CAB15876" /db_xref="GOA:P39581" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR010072" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="PDB:3E7W" /db_xref="PDB:3E7X" /db_xref="SubtiList:BG10551" /db_xref="UniProtKB/Swiss-Prot:P39581" /translation="MKLLHAIQTHAETYPQTDAFRSQGQSLTYQELWEQSDRAAAAIQ KRISGEKKSPILVYGHMEPHMIVSFLGSVKAGHPYIPVDLSIPSERIAKIIESSGAEL LIHAAGLSIDAVGQQIQTVSAEELLENEGGSVSQDQWVKEHETFYIIYTSGSTGNPKG VQISAANLQSFTDWICADFPVSGGKIFLNQAPFSFDLSVMDLYPCLQSGGTLHCVTKD AVNKPKVLFEELKKSGLNVWTSTPSFVQMCLMDPGFSQDLLPHADTFMFCGEVLPVSV AKALLERFPKAKIFNTYGPTEATVAVTSVEITNDVISRSESLPVGFAKPDMNIFIMDE EGQPLPEGEKGEIVIAGPSVSRGYLGEPELTEKAFFSHEGQWAYRTGDAGFIQDGQIF CQGRLDFQIKLHGYRMELEEIEFHVRQSQYVRSAVVIPYQPNGTVEYLIAAIVPEEHE FEKEFQLTSAIKKELAASLPAYMIPRKFIYQDHIQMTANGKIDRKRIGEEVLV*" /label="dltA CDS" gene 3569530..3571041 /gene="dltA" /locus_tag="BSU_38500" /old_locus_tag="BSU38500" /label="dltA gene" CDS 3571038..3572225 /gene="dltB" /locus_tag="BSU_38510" /old_locus_tag="BSU38510" /function="16.1: Circulate" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11222605, 12028417, 14665680, 15849754, 16850406, 17263852; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="putative D-alanine transferase from DCP to undecaprenylphosphate for lipoteichoic acid and wall teichoic acid" /protein_id="NP_391730.1" /db_xref="EnsemblGenomes-Gn:BSU38510" /db_xref="EnsemblGenomes-Tr:CAB15877" /db_xref="GOA:P39580" /db_xref="InterPro:IPR004299" /db_xref="InterPro:IPR024024" /db_xref="InterPro:IPR024194" /db_xref="SubtiList:BG10550" /db_xref="UniProtKB/Swiss-Prot:P39580" /translation="MTPYSSFLFFILLGILLLPTIILGLNGKRFQAYNMFISIIILAL IFSHDLHGVIALCLFTIWQVLLISGYLAYRQKANSGFVFCGAVIASILPLFLSKIWPF LSHPQPHHPPHNLISFLGISYLTFKGVQLIMEARDGLLKEQLPLHRLLYFILFFPTIS SGPIDRYRRFVKDEQKAWTKEEYADLLYTGIHKIFIGFLYKFIIGYAINTYFIMNLPA ITHNKILGNLLYMYGYSMYLFFDFAGYTMFAVGVSYIMGIKSPENFNKPFISKNIKDF WNRWHMSLSFWFRDYVFMRFVFWMTKKKWIKNRMAVSNIGYFLLFMLMGVWHGLAPQY IIYGLYHAVLMTCYNFFEKWNKKYKWLPSNRWTTILAIVITFHFVCFGFYIFSGKPFH HHH*" /label="dltB CDS" gene 3571038..3572225 /gene="dltB" /locus_tag="BSU_38510" /old_locus_tag="BSU38510" /label="dltB gene" CDS 3572242..3572478 /gene="dltC" /locus_tag="BSU_38520" /old_locus_tag="BSU38520" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7797557, 11222605, 14665680, 15955059, 26193422" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7797557, 11222605, 14665680, 15955059, 26193422; Product type c: carrier" /codon_start=1 /transl_table=11 /product="D-alanyl carrier protein" /protein_id="NP_391731.1" /db_xref="EnsemblGenomes-Gn:BSU38520" /db_xref="EnsemblGenomes-Tr:CAB15878" /db_xref="GOA:P39579" /db_xref="InterPro:IPR003230" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR036736" /db_xref="PDB:4BPF" /db_xref="PDB:4BPG" /db_xref="PDB:4BPH" /db_xref="SubtiList:BG10549" /db_xref="UniProtKB/Swiss-Prot:P39579" /translation="MDFKQEVLDVLAEVCQDDIVKENPDIEIFEEGLLDSFGTVELLL AIENRFDILVPITEFDRDVWNTPNNIVNQLSELK*" /label="dltC CDS" gene 3572242..3572478 /gene="dltC" /locus_tag="BSU_38520" /old_locus_tag="BSU38520" /label="dltC gene" CDS 3572478..3573656 /gene="dltD" /locus_tag="BSU_38530" /old_locus_tag="BSU38530" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11222605, 12028417, 14665680, 17263852, 17600057, 23858088; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="putative D-alanine from undecaprenylphosphate tothe polyglycerolphosphate chain for lipoteichoic acid andwall teichoic acid synthesis" /protein_id="NP_391732.1" /db_xref="EnsemblGenomes-Gn:BSU38530" /db_xref="EnsemblGenomes-Tr:CAB15879" /db_xref="GOA:P39578" /db_xref="InterPro:IPR006998" /db_xref="InterPro:IPR023896" /db_xref="InterPro:IPR036514" /db_xref="SubtiList:BG10548" /db_xref="UniProtKB/Swiss-Prot:P39578" /translation="MKKRFFGPIILAFILFAGAIAIPSSWLTGFITDKRVKESATALN PSMFQGLYLQDQMLKDPTYLPIYGSSELSRLDEFHPSNYFQVNNEGFTPYLVGKGGSQ SLIHSLNFAAHMDQLKGKKIVFIVSPQWFIKRGSDEQHFAPNYSALQGLDLAFNDQID PEIKKKMMKRMLRFKAVQNDAILSELYKAMVNGQTWKVNALKPAAKVYYSMLEKKDLY YSTTESSGPKRYISQSVKDKSWSELNKLADQSGKRHSGSNDFHIDNPVYKKLKPKVPK LKGKNKGRSYAVSPEYGDFEMMLDILKDAGAEPMFVTIPVNGKWYDYTGFPKKGRTDY YKKVNKQIRAKGFQVADFSGHEYDPYFMKDTIHIGWKGWVYVDKAIDEFYKTGKVTSS *" /label="dltD CDS" gene 3572478..3573656 /gene="dltD" /locus_tag="BSU_38530" /old_locus_tag="BSU38530" /label="dltD gene" S_feature 3573657..3573746 /Source="Nicolas_S_feature" /locus_tag="new_3956402_3956491" /HighExp="Paraq, H2O2, Oxctl, LBGexp, Lbexp, dia0, C30, Cold, G150, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.998" /label="S1480" CDS 3573747..3574505 /gene="dltE" /locus_tag="BSU_38540" /old_locus_tag="BSU38540" /EC_number="1.-.-.-" /function="16.8: Protect" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7797557, 14665680; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391733.2" /db_xref="EnsemblGenomes-Gn:BSU38540" /db_xref="EnsemblGenomes-Tr:CAB15880" /db_xref="GOA:P39577" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10547" /db_xref="UniProtKB/Swiss-Prot:P39577" /translation="MKMTNNTVLITGGSAGIGLELAKRLLELGNEVIICGRSEARLAE AKQQLPNIHTKQCDVADRSQREALYEWALKEYPNLNVLVNNAGIQKEIDFKKGTEELF VDGDEIELNFQAPVHLSALFTPHLMKQPEAAIVQVTSGLAFNPLAVYPVYCATKAALH SFSLTLRHQLRDTSVEVIEMAPPMVDTGLNQKSRDKQGLTYRGISSEEYVQYFLDGLK EGKQEITNERVEGLRDATRADYDRLFEQMNTQEN*" /label="dltE CDS" gene 3573747..3574505 /gene="dltE" /locus_tag="BSU_38540" /old_locus_tag="BSU38540" /label="dltE gene" downshifts 3574473 /Source="Nicolas_upshifts" /id="D1997" /incds=0 /nref=48 /ntot=172 /MaxReadThrough="5.94016" /MaxDrop="4.72547" /score="22.6844301" /energy="-13.7" /TU="U3035" /idTUdmin="U3035" /TUdmin="-1254" /isTUend="FALSE" /label="downshifts" S_feature complement(3574507..3575734) /Source="Nicolas_S_feature" /locus_tag="new_3957252_3958479_c" /HighExp="T0.30H, T1.0H, T1.30H, C30, B60, T2.0H, C90, Gly, T2.30H, S8" /AntisenseName="ilvK" /AntisenseCor="-0.12928749136401099" /AntisenseRegPval="-1.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.978" /TUlongSig="NA" /TUlongPSig="NA" /label="S1481" promotor_-35 3574553..3574560 /Source="Nicolas_upshift_promotors" /id="U3037" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.82017982017982" /psig="0.999000999001" /xcortree=3073 /SigmaFactorBS="gaatttcttacaaatttgagcaaaccTATTGCGAttatttgt tgaagGTATACAATAGAATATAATTattttcaaataagtttgataatataaacaattt a" /listShort="ilvK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3574574..3574593 /Source="Nicolas_upshift_promotors" /id="U3037" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.82017982017982" /psig="0.999000999001" /xcortree=3073 /SigmaFactorBS="gaatttcttacaaatttgagcaaaccTATTGCGAttatttgt tgaagGTATACAATAGAATATAATTattttcaaataagtttgataatataaacaattt a" /listShort="ilvK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3574587 /Source="Nicolas_upshifts" /id="U3037" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.82017982017982" /psig="0.999000999001" /xcortree=3073 /SigmaFactorBS="gaatttcttacaaatttgagcaaaccTATTGCGAttatttgt tgaagGTATACAATAGAATATAATTattttcaaataagtttgataatataaacaattt a" /listShort="ilvK" /GFF_Attribute="listLong" /label="upshifts" CDS 3574646..3575737 /gene="ilvK" /locus_tag="BSU_38550" /old_locus_tag="BSU38550" /EC_number="2.6.1.42" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12670965, 17611193, 22938038" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12670965, 17611193, 22938038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branched-chain amino acid aminotransferase" /protein_id="NP_391734.2" /db_xref="EnsemblGenomes-Gn:BSU38550" /db_xref="EnsemblGenomes-Tr:CAB15881" /db_xref="GOA:P39576" /db_xref="InterPro:IPR001544" /db_xref="InterPro:IPR005786" /db_xref="InterPro:IPR018300" /db_xref="InterPro:IPR033939" /db_xref="InterPro:IPR036038" /db_xref="SubtiList:BG10546" /db_xref="UniProtKB/Swiss-Prot:P39576" /translation="MTKQTIRVELTSTKKPKPDPNQLSFGRVFTDHMFVMDYAADKGW YDPRIIPYQPLSMDPAAMVYHYGQTVFEGLKAYVSEDDHVLLFRPEKNMERLNQSNDR LCIPQIDEEQVLEGLKQLVAIDKDWIPNAEGTSLYIRPFIIATEPFLGVAASHTYKLL IILSPVGSYYKEGIKPVKIAVESEFVRAVKGGTGNAKTAGNYASSLKAQQVAEEKGFS QVLWLDGIEKKYIEEVGSMNIFFKINGEIVTPMLNGSILEGITRNSVIALLKHWGLQV SERKIAIDEVIQAHKDGILEEAFGTGTAAVISPVGELIWQDETLSINNGETGEIAKKL YDTITGIQKGAVADEFGWTTEVAALTESK*" /label="ilvK CDS" gene 3574646..3575737 /gene="ilvK" /locus_tag="BSU_38550" /old_locus_tag="BSU38550" /label="ilvK gene" downshifts 3575639 /Source="Nicolas_upshifts" /id="D1998" /incds=1 /nref=10 /ntot=90 /MaxReadThrough="6.0829" /MaxDrop="3.1965" /score="32.8755878" /energy="-13.6" /TU="U3035,U3037" /idTUdmin="U3035" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" downshifts 3575727 /Source="Nicolas_upshifts" /id="D1999" /incds=0 /nref=157 /ntot=264 /MaxReadThrough="2.21106" /MaxDrop="6.83094" /score="32.8755878" /energy="-13.6" /TU="NA" /idTUdmin="U3035" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3575771..3577099) /gene="licH" /locus_tag="BSU_38560" /old_locus_tag="BSU38560" /EC_number="3.2.1.86" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 8990303, 10438772, 22720735, 23874669, 24673833; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="6-phospho-beta-glucosidase" /protein_id="NP_391735.1" /db_xref="EnsemblGenomes-Gn:BSU38560" /db_xref="EnsemblGenomes-Tr:CAB15882" /db_xref="GOA:P46320" /db_xref="InterPro:IPR001088" /db_xref="InterPro:IPR015955" /db_xref="InterPro:IPR019802" /db_xref="InterPro:IPR022616" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11350" /db_xref="UniProtKB/Swiss-Prot:P46320" /translation="MTKGLKIVTIGGGSSYTPELVEGFIKRYDELPVRELWLVDIPEG EEKLNIVGTLAKRMVEKAGVPIDIHLTLDRRKALKDADFVTTQFRVGLLQARAKDERI PLKYGVIGQETNGPGGLFKGLRTIPVILEIAKDIEELCPNAWLVNFTNPAGMVTEALL RYSNLKKVVGLCNVPIGIKMGVAKALDVDVDRVEVQFAGLNHMVFGLDVFLDGVSVKE QVIEAMGDPKNAMTMKNISGAEWEPDFLKALNVIPCGYHRYYFKTKEMLEHELEASQT EGTRAEVVQKVEKELFELYKDPNLAIKPPQLEKRGGAYYSDAACNLISSIYNDKHDIQ PVNTINNGAIASIPDDSAVEVNCVMTKTGPKPIAVGDLPVSVRGLVQQIKSFERVAAE AAVTGDYQTALLAMTINPLVPSDTVAKQILDEMLEAHKAYLPQFFNKIEA*" /label="licH CDS" gene complement(3575771..3577099) /gene="licH" /locus_tag="BSU_38560" /old_locus_tag="BSU38560" /label="licH gene" downshifts complement(3575779) /Source="Nicolas_upshifts" /id="D2000" /incds=0 /nref=12 /ntot=98 /MaxReadThrough="4.92442" /MaxDrop="6.75565" /score="45.1562234" /energy="-15.7" /TU="U3038" /idTUdmin="U3038" /TUdmin="-152" /isTUend="FALSE" /label="downshifts" CDS complement(3577096..3577428) /gene="licA" /locus_tag="BSU_38570" /old_locus_tag="BSU38570" /function="16.1: Circulate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8990303, 10438772, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8990303, 10438772, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) lichenan-specific enzyme IIA component" /protein_id="NP_391736.1" /db_xref="EnsemblGenomes-Gn:BSU38570" /db_xref="EnsemblGenomes-Tr:CAB15883" /db_xref="GOA:P46319" /db_xref="InterPro:IPR003188" /db_xref="InterPro:IPR036542" /db_xref="SubtiList:BG11349" /db_xref="UniProtKB/Swiss-Prot:P46319" /translation="MNEEMEQIIFQIILHGGNGRSSAMEAIAAAKSGDAEEARKKLQD AAEELSKAHHYQTELIQNEAGGEKTEMTLLMVHAQDHLMNAMTVKDMAAEIIELYEKI TEQRGASI*" /label="licA CDS" gene complement(3577096..3577428) /gene="licA" /locus_tag="BSU_38570" /old_locus_tag="BSU38570" /label="licA gene" CDS complement(3577447..3578805) /gene="licC" /locus_tag="BSU_38580" /old_locus_tag="BSU38580" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8990303, 10438772, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8990303, 10438772, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) lichenan-specific enzyme IIC component" /protein_id="NP_391737.1" /db_xref="EnsemblGenomes-Gn:BSU38580" /db_xref="EnsemblGenomes-Tr:CAB15884" /db_xref="GOA:P46317" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR004501" /db_xref="InterPro:IPR004796" /db_xref="SubtiList:BG11348" /db_xref="UniProtKB/Swiss-Prot:P46317" /translation="MNKVNQILEEKVMPIAGRIAGQRHLQALRDGIILTMPLIIIGSF FLIIGNLPIPGYAEFMAKTFGSSWSEKLAYPVDATFEIMGLVAAFGIAYRLAEKYGVD ALSAGAISLAAFLLATPYQVPFMPDGATKEIMVGGGIPLSLMGSKGLFVAMIIAMVST EIYRLIIQRNLVFKMPDGVPPAVSKSFVALIPGFAVIFLIWAARLIVEATPFESLHNI VSVLLGTPLSILGGSLGGSLVAEAVKMLLWACGLHGANIVGGVMAPIWYGAMDANRIA FQAGEELPKIFTQQFFDIWVNIGGSGATLALVVTMFLRARSKQMKQLGKLAVGPAIFN INEPIIFGMPIVMNPMLLLPFIITPLVTVTLTYIGMSTGLVAKPAGIAVPWTMPPIFS GYLATGGKVSGAVMQAINIAVSFVVYYPFFRMWDKQKLKEENDLELVQTPAATDDKEA AL*" /label="licC CDS" gene complement(3577447..3578805) /gene="licC" /locus_tag="BSU_38580" /old_locus_tag="BSU38580" /label="licC gene" CDS complement(3578821..3579129) /gene="licB" /locus_tag="BSU_38590" /old_locus_tag="BSU38590" /EC_number="2.7.1.-" /function="16.1: Circulate" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8990303, 10438772, 23874669" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8990303, 10438772, 23874669; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) lichenan-specific enzyme IIB component" /protein_id="NP_391738.1" /db_xref="EnsemblGenomes-Gn:BSU38590" /db_xref="EnsemblGenomes-Tr:CAB15885" /db_xref="GOA:P46318" /db_xref="InterPro:IPR003501" /db_xref="InterPro:IPR013012" /db_xref="InterPro:IPR036095" /db_xref="SubtiList:BG11347" /db_xref="UniProtKB/Swiss-Prot:P46318" /translation="MNILLVCAAGMSTSLLVSKMEKSAQEQGKDYTIWAVSGDSVQNH IDKADVLLLGPQVRYMLPQLKKLGESKGVPVDVINTVHYGTCNGAEVLKSAEQLGHVS *" /label="licB CDS" gene complement(3578821..3579129) /gene="licB" /locus_tag="BSU_38590" /old_locus_tag="BSU38590" /label="licB gene" promotor_-10 complement(3579174..3579193) /Source="Nicolas_upshift_promotors" /id="U3038" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig="0.978021978021978" /xcortree=354 /SigmaFactorBS="tatataccttttttccgttgcctgcggaaaaaccctgAGTGT TTatgaaagcgatttCATAATATGATGATAGCAACagcaggacattacaaaattgatc a" /listShort="licB, licC, licA, licH, S1481" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3579190) /Source="Nicolas_upshifts" /id="U3038" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig="0.978021978021978" /xcortree=354 /SigmaFactorBS="tatataccttttttccgttgcctgcggaaaaaccctgAGTGT TTatgaaagcgatttCATAATATGATGATAGCAACagcaggacattacaaaattgatc a" /listShort="licB, licC, licA, licH, S1481" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3579207..3579213) /Source="Nicolas_upshift_promotors" /id="U3038" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig="0.978021978021978" /xcortree=354 /SigmaFactorBS="tatataccttttttccgttgcctgcggaaaaaccctgAGTGT TTatgaaagcgatttCATAATATGATGATAGCAACagcaggacattacaaaattgatc a" /listShort="licB, licC, licA, licH, S1481" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3579258) /Source="Nicolas_upshifts" /id="D2001" /incds=0 /nref=3 /ntot=74 /MaxReadThrough="3.19679" /MaxDrop="2.70222" /score="27.6067633" /energy="-11.1" /TU="U3040" /idTUdmin="U3040" /TUdmin="-45" /isTUend="FALSE" /label="downshifts" CDS complement(3579258..3581183) /gene="licR" /locus_tag="BSU_38600" /old_locus_tag="BSU38600" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8990303, 9353933, 10438772" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8990303, 9353933, 10438772; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional activator of the lichenan operon" /protein_id="NP_391739.1" /db_xref="EnsemblGenomes-Gn:BSU38600" /db_xref="EnsemblGenomes-Tr:CAB15886" /db_xref="GOA:P46321" /db_xref="InterPro:IPR002178" /db_xref="InterPro:IPR007737" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR013011" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR016152" /db_xref="InterPro:IPR036095" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="InterPro:IPR036634" /db_xref="SubtiList:BG11346" /db_xref="UniProtKB/Swiss-Prot:P46321" /translation="MLHGRLRDILRLLMAAEAPVTSSFFAAQLNVTTRTVRNDIKELQ GVLSGHGAFVQSVRGSGYKLRIDDEQVFRTLLQDEFQQKKGLPVLPEERMAYLMKRLL LADHYLKLDELAEELFISKSTLQTDLKEVKKRLLPYRIVMETRPNYGFKLRGDEVQMR YCMAEYIVDERETEIDVLNEKADILPKEEIEIIRSAILKKMKNDRIPLSNMGLNNLII HIAIACKRIRTENYVSLFPKDMDHILHQKEYQAAEAIVKELESKLSVTFPKDETAYIT MHLLGTKRMTQSQCGEDTFSIEEETDQLTLAMIKAVDRELKLGILHDKELKIGLALHM KPAISRNRYGMNLRNPMLAAIKEHYPLAFEAGIIAGIVIKEQTGIEIHENEIGYLALH FGAAIERKKTESPPKRCIIVCASGAGSAQLLREKLRSHFGKRLDILGTAEYYSLDQMS YESIDFVISTIPIKKELPVPVLKVNTILGGTDFTKIESILSDEKEKANRYLKKELVFF QEDLRSKEEVIQFLGQKVVECGFADEEIIDSIFEREDMSPTCFGNLVAIPHPLVPQTK TTFWAVCTLKKPIDWESQRVQFVCLLCVEKENKADLQSMYKLLGSILDDPAAMNQLIK CRSYQELSDVFDQKMLS*" /label="licR CDS" gene complement(3579258..3581183) /gene="licR" /locus_tag="BSU_38600" /old_locus_tag="BSU38600" /label="licR gene" promotor_-35 3579921..3579930 /Source="Nicolas_upshift_promotors" /id="U3039" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1369 /SigmaFactorBS="aaatgggaacgcagtttttcgcgcagaagCTGGGCGCTTccg gctcccgatgCGCATACAATGATACAGCGTttcggcgggctttctgttttttttcgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3579944..3579963 /Source="Nicolas_upshift_promotors" /id="U3039" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1369 /SigmaFactorBS="aaatgggaacgcagtttttcgcgcagaagCTGGGCGCTTccg gctcccgatgCGCATACAATGATACAGCGTttcggcgggctttctgttttttttcgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3579952 /Source="Nicolas_upshifts" /id="U3039" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1369 /SigmaFactorBS="aaatgggaacgcagtttttcgcgcagaagCTGGGCGCTTccg gctcccgatgCGCATACAATGATACAGCGTttcggcgggctttctgttttttttcgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3581256..3581273) /Source="Nicolas_upshift_promotors" /id="U3040" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.699300699300699" /psig=1 /xcortree=3153 /SigmaFactorBS="gctgtttttttataggtcagttttccctctagtcctccggat gttCATTGACTtgccattctctccaTTATAGAATTTATATACAtttcgcatcccttca t" /listShort="licR" /listLong="licB, licC, licA, licH" /label="promotor_-10" upshifts complement(3581280) /Source="Nicolas_upshifts" /id="U3040" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.699300699300699" /psig=1 /xcortree=3153 /SigmaFactorBS="gctgtttttttataggtcagttttccctctagtcctccggat gttCATTGACTtgccattctctccaTTATAGAATTTATATACAtttcgcatcccttca t" /listShort="licR" /listLong="licB, licC, licA, licH" /label="upshifts" promotor_-35 complement(3581288..3581295) /Source="Nicolas_upshift_promotors" /id="U3040" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.699300699300699" /psig=1 /xcortree=3153 /SigmaFactorBS="gctgtttttttataggtcagttttccctctagtcctccggat gttCATTGACTtgccattctctccaTTATAGAATTTATATACAtttcgcatcccttca t" /listShort="licR" /listLong="licB, licC, licA, licH" /label="promotor_-35" CDS complement(3581346..3581504) /gene="yxzF" /locus_tag="BSU_38610" /old_locus_tag="BSU38610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391740.1" /db_xref="EnsemblGenomes-Gn:BSU38610" /db_xref="EnsemblGenomes-Tr:CAB15887" /db_xref="SubtiList:BG14169" /db_xref="UniProtKB/Swiss-Prot:O32283" /translation="MVEKKEGRIGALKKMIKTVIKWAPVIYPIVRKIMKDRKASKQKN MSASRTAG*" /label="yxzF CDS" gene complement(3581346..3581504) /gene="yxzF" /locus_tag="BSU_38610" /old_locus_tag="BSU38610" /label="yxzF gene" downshifts complement(3581373) /Source="Nicolas_upshifts" /id="D2002" /incds=0 /nref=75 /ntot=208 /MaxReadThrough="0.739420000000001" /MaxDrop="6.4099" /score="27.6067633" /energy="-11.1" /TU="NA" /idTUdmin="U3041" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS complement(3581533..3582123) /gene="aag" /locus_tag="BSU_38620" /old_locus_tag="BSU38620" /EC_number="3.2.2.-" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:14729667, 27698084" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14729667, 27698084; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-alkylated purines and hypoxanthine DNA glycosidase" /protein_id="NP_391741.1" /db_xref="EnsemblGenomes-Gn:BSU38620" /db_xref="EnsemblGenomes-Tr:CAB15888" /db_xref="GOA:P94378" /db_xref="InterPro:IPR003180" /db_xref="InterPro:IPR011034" /db_xref="InterPro:IPR036995" /db_xref="SubtiList:BG12555" /db_xref="UniProtKB/Swiss-Prot:P94378" /translation="MTREKNPLPITFYQKTALELAPSLLGCLLVKETDEGTASGYIVE TEAYMGAGDRAAHSFNNRRTKRTEIMFAEAGRVYTYVMHTHTLLNVVAAEEDVPQAVL IRAIEPHEGQLLMEERRPGRSPREWTNGPGKLTKALGVTMNDYGRWITEQPLYIESGY TPEAISTGPRIGIDNSGEARDYPWRFWVTGNRYVSR*" /label="aag CDS" gene complement(3581533..3582123) /gene="aag" /locus_tag="BSU_38620" /old_locus_tag="BSU38620" /label="aag gene" promotor_-10 complement(3582151..3582169) /Source="Nicolas_upshift_promotors" /id="U3041" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.921078921078921" /psig="0.921078921078921" /xcortree=132 /SigmaFactorBS="aatattccctgaatggaaagattttaaaacagcCGTTTTTtt tgatctgcttcGGGAATGGTACAATGTACAaaaatcggtaaaaggagaggtcgattcg t" /listShort="aag, yxzF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3582162) /Source="Nicolas_upshifts" /id="U3041" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.921078921078921" /psig="0.921078921078921" /xcortree=132 /SigmaFactorBS="aatattccctgaatggaaagattttaaaacagcCGTTTTTtt tgatctgcttcGGGAATGGTACAATGTACAaaaatcggtaaaaggagaggtcgattcg t" /listShort="aag, yxzF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3582183..3582189) /Source="Nicolas_upshift_promotors" /id="U3041" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.921078921078921" /psig="0.921078921078921" /xcortree=132 /SigmaFactorBS="aatattccctgaatggaaagattttaaaacagcCGTTTTTtt tgatctgcttcGGGAATGGTACAATGTACAaaaatcggtaaaaggagaggtcgattcg t" /listShort="aag, yxzF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3582192..3582198 /Source="Nicolas_upshift_promotors" /id="U3042" /multdbtbs="SigB,SigF" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=727 /SigmaFactorBS="ttgtaccattcccgaagcagatcaaaaaaaacggcTGTTTTA aaatctttccattcaGGGAATATTGTTACCGTTCaaaaaaggagggccaaccattgaa a" /listShort="katX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3582214..3582232 /Source="Nicolas_upshift_promotors" /id="U3042" /multdbtbs="SigB,SigF" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=727 /SigmaFactorBS="ttgtaccattcccgaagcagatcaaaaaaaacggcTGTTTTA aaatctttccattcaGGGAATATTGTTACCGTTCaaaaaaggagggccaaccattgaa a" /listShort="katX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3582217 /Source="Nicolas_upshifts" /id="U3042" /multdbtbs="SigB,SigF" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=727 /SigmaFactorBS="ttgtaccattcccgaagcagatcaaaaaaaacggcTGTTTTA aaatctttccattcaGGGAATATTGTTACCGTTCaaaaaaggagggccaaccattgaa a" /listShort="katX" /GFF_Attribute="listLong" /label="upshifts" CDS 3582252..3583895 /gene="katX" /locus_tag="BSU_38630" /old_locus_tag="BSU38630" /EC_number="1.11.1.6" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9393707, 9555886, 10503549, 24123749" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9393707, 9555886, 10503549, 24123749; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="major catalase in spores" /protein_id="NP_391742.1" /db_xref="EnsemblGenomes-Gn:BSU38630" /db_xref="EnsemblGenomes-Tr:CAB15889" /db_xref="GOA:P94377" /db_xref="InterPro:IPR002226" /db_xref="InterPro:IPR010582" /db_xref="InterPro:IPR011614" /db_xref="InterPro:IPR018028" /db_xref="InterPro:IPR020835" /db_xref="InterPro:IPR024708" /db_xref="InterPro:IPR024711" /db_xref="InterPro:IPR037060" /db_xref="SubtiList:BG11945" /db_xref="UniProtKB/Swiss-Prot:P94377" /translation="MKDDHQNKQHQSNAQGSEEAFSHKTSGKNESEDTLTNRQGHPVT DNQNVRTVGNRGPTTLENYDFLEKISHFDRERIPERVVHARGAGAHGYFEAYGSFGDE PISTYTRAKLFQEKGKKTPAFVRFSTVNHGKHSPETLRDPRGFAVKLYTEDGNWDLVG NNLKIFFIRDPLKFPDLVHAFQPDPVTNIQDGERIFDFISQSPEATHMITFLFSPWGI PANYRQMQGSGVHAYKWVNEEGKAVLVKYHFEPKQGIRNLTQKEAEEIQGKNFNHATQ DLYDAIENGDYPEWEVYAQIMSDDEHPELDFDPLDPTKLWYKDDFPWKPIGKLVLNKN PENYHAEVEQASFGTGVLVDGLDFSDDKLLQGRTFAYSDTQRYRVGANYLQLPINSPK KHVATNQEGGQMQYRVDRAEGQNPHVNYEPSIMGGLKEAKQDGKDHTPHVEGDVKREA IDRTNNFGQAGETYRRFTEFERNELITNLVNTLSTCRKEIQDQMIENFTKADPDYGKR VAEGLKKVSENNSNGPIGTTETEQAAKQAEQESHPSDPY*" /label="katX CDS" gene 3582252..3583895 /gene="katX" /locus_tag="BSU_38630" /old_locus_tag="BSU38630" /label="katX gene" S_feature complement(3582389..3583938) /Source="Nicolas_S_feature" /locus_tag="new_3965134_3966683_c" /HighExp="T0.30H, T1.0H, T1.30H, T2.0H, T2.30H, T3.0H, S8, T3.30H, S6, T0.0H" /AntisenseName="katX" /AntisenseCor="0.28909015498211399" /AntisenseRegPval="-5.8" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1482" downshifts 3583890 /Source="Nicolas_upshifts" /id="D2003" /incds=0 /nref=28 /ntot=49 /MaxReadThrough="0.942820000000001" /MaxDrop="5.69337" /score="45.0252072" /energy="-12.7" /TU="NA" /idTUdmin="U3042" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3583940..3584031) /Source="Nicolas_S_feature" /locus_tag="new_3966685_3966776_c" /HighExp="T0.30H, T1.30H, T1.0H, T2.0H, T2.30H, T3.30H, T4.0H, T3.0H, T0.0H, T5.0H" /AntisenseName="yxlH" /AntisenseCor="-4.8005444617814199E-3" /AntisenseRegPval=0 /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1483" promotor_-35 3583942..3583948 /Source="Nicolas_upshift_promotors" /id="U3043" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig="0.914085914085914" /xcortree=1556 /SigmaFactorBS="caacagcgaacagggcttttttagaagccctgtttttttatt tttcTATTGAAacgctttcaataatTGTGTTGTACTTGGAAGGAAaggggtggagaga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3583956 /Source="Nicolas_upshifts" /id="U3043" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig="0.914085914085914" /xcortree=1556 /SigmaFactorBS="caacagcgaacagggcttttttagaagccctgtttttttatt tttcTATTGAAacgctttcaataatTGTGTTGTACTTGGAAGGAAaggggtggagaga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3583963..3583982 /Source="Nicolas_upshift_promotors" /id="U3043" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig="0.914085914085914" /xcortree=1556 /SigmaFactorBS="caacagcgaacagggcttttttagaagccctgtttttttatt tttcTATTGAAacgctttcaataatTGTGTTGTACTTGGAAGGAAaggggtggagaga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(3583983) /Source="Nicolas_upshifts" /id="D2004" /incds=0 /nref=8 /ntot=42 /MaxReadThrough="3.81662" /MaxDrop="3.1285" /score="-7.60062702" /energy="-7.5" /TU="U3045" /idTUdmin="U3045" /TUdmin="-1557" /isTUend="FALSE" /label="downshifts" CDS 3584000..3585202 /gene="yxlH" /locus_tag="BSU_38640" /old_locus_tag="BSU38640" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14769884, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_391743.1" /db_xref="EnsemblGenomes-Gn:BSU38640" /db_xref="EnsemblGenomes-Tr:CAB15890" /db_xref="GOA:P94376" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12554" /db_xref="UniProtKB/Swiss-Prot:P94376" /translation="MELQQDLIPQKKTIGALDHAVFLCMVFCFWFSGYIYVPVFSLYL EDLHFSYGAIGIILGSYGVTQILLRFPLGLLSDILFSLRKQLLIAGFGFSVLSSLLFL MFDSFFFVLAARLFAGITASTWVMATILYAHYFNNGNASKAMGIMQFFTVMPQFASIV FCGLAAAHLGRQVPFWMALAASAAGLVICCFIQDPSAPPANRGTIRVNQYIKDTLRLP KLKLFTILSMTAHAVLFITVFGFTPLYMNQLGMGDAELLWVMSAFFLPHAAATLSFVF LRFTSRIAYSVMLISFAVTGVCLLYVPFLAALFTVCITHACIGLALGFVFPLLLSHVV EISSARLKMSVMGFYQSFYALGIFLGPLLAGKIAQLIGLAGVFYGAGSLAFAAFFVML AQKRNMIN*" /label="yxlH CDS" gene 3584000..3585202 /gene="yxlH" /locus_tag="BSU_38640" /old_locus_tag="BSU38640" /label="yxlH gene" S_feature complement(3584033..3585198) /Source="Nicolas_S_feature" /locus_tag="new_3966778_3967943_c" /HighExp="T1.0H, T1.30H, T0.30H, T2.0H, T2.30H, T0.0H, T3.0H, T3.30H, T-0.40H, T4.0H" /AntisenseName="yxlH" /AntisenseCor="-4.5703316381945601E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1484" downshifts complement(3584076) /Source="Nicolas_upshifts" /id="D2005" /incds=1 /nref=3 /ntot=61 /MaxReadThrough="6.44992" /MaxDrop="2.92619" /score="-7.60062702" /energy="-7.5" /TU="U3045" /idTUdmin="U3045" /TUdmin="-1650" /isTUend="FALSE" /label="downshifts" CDS complement(3585199..3585975) /gene="yxlG" /locus_tag="BSU_38650" /old_locus_tag="BSU38650" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14769884, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC-transporter (permease)" /protein_id="NP_391744.2" /db_xref="EnsemblGenomes-Gn:BSU38650" /db_xref="EnsemblGenomes-Tr:CAB15891" /db_xref="GOA:P94375" /db_xref="InterPro:IPR032688" /db_xref="SubtiList:BG12553" /db_xref="UniProtKB/Swiss-Prot:P94375" /translation="MKVMMALLQKEWLEGWKSGKLIWLPIAMMIVGLTQPLTIYYMPE IIAHGGNLPDGMKISFTMPSGSEVMVSTLSQFNTLGMALVIFSVMGSVANERNQGVTA LIMSRPVTAAHYIVSKWLIQSVIGIMSFAAGYGLAYYYVRLLFEDASFSRFAASLGLY ALWVIFIVTAGLAGSTIFRSVGAAAACGIGLTAAVSFAVSLFPDGAKWLPAEICKQAE HILLHGERADFFGWSLTFSILCIMLLAVFSVWRFRRYESY*" /label="yxlG CDS" gene complement(3585199..3585975) /gene="yxlG" /locus_tag="BSU_38650" /old_locus_tag="BSU38650" /label="yxlG gene" CDS complement(3585972..3586859) /gene="yxlF" /locus_tag="BSU_38660" /old_locus_tag="BSU38660" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12897008, 14769884, 14993308; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter component (ATP-binding protein)" /protein_id="NP_391745.1" /db_xref="EnsemblGenomes-Gn:BSU38660" /db_xref="EnsemblGenomes-Tr:CAB15892" /db_xref="GOA:P94374" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR025302" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12552" /db_xref="UniProtKB/Swiss-Prot:P94374" /translation="MLSIESLCKSYRHHEAVKNVSFHVNENECVALLGPNGAGKTTTL QMLAGLLSPTSGTIKLLGEKKLDRRLIGYLPQYPAFYSWMTANEFLTFAGRLSGLSKR KCQEKIGEMLEFVGLHEAAHKRIGGYSGGMKQRLGLAQALLHKPKFLILDEPVSALDP TGRFEVLDMMRELKKHMAVLFSTHVLHDAEQVCDQVVIMKNGEISWKGELQELKQQQQ TNVFTLSVKEKLEGWLEEKPYVSAIVYKNPSQAVFELPDIHAGRSLLSDCIRKGLTVT RFEQKTESLEDVYLKVVHA*" /label="yxlF CDS" gene complement(3585972..3586859) /gene="yxlF" /locus_tag="BSU_38660" /old_locus_tag="BSU38660" /label="yxlF gene" CDS complement(3586866..3587054) /gene="yxlE" /locus_tag="BSU_38670" /old_locus_tag="BSU38670" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12897008, 14769884, 14993308" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12897008, 14769884, 14993308; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of sigma-Y activity" /protein_id="NP_391746.1" /db_xref="EnsemblGenomes-Gn:BSU38670" /db_xref="EnsemblGenomes-Tr:CAB15893" /db_xref="GOA:P94373" /db_xref="InterPro:IPR027379" /db_xref="SubtiList:BG12551" /db_xref="UniProtKB/Swiss-Prot:P94373" /translation="MNISWEMILPLIVLQLALAVFALISCIKEERTNGPKWMWAAIIV CINIIGPILFFTVGRKQR*" /label="yxlE CDS" gene complement(3586866..3587054) /gene="yxlE" /locus_tag="BSU_38670" /old_locus_tag="BSU38670" /label="yxlE gene" CDS complement(3587051..3587257) /gene="yxlD" /locus_tag="BSU_38680" /old_locus_tag="BSU38680" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12897008, 14769884, 14993308; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative sigma-Y antisigma factor component" /protein_id="NP_391747.1" /db_xref="EnsemblGenomes-Gn:BSU38680" /db_xref="EnsemblGenomes-Tr:CAB15894" /db_xref="GOA:P94372" /db_xref="SubtiList:BG12550" /db_xref="UniProtKB/Swiss-Prot:P94372" /translation="MTQTEIIITVAACLIVLAQGIFLFIDAKKRNHMAWVWGIVGLIQ APMPLICYYFFVIRPDRKKRGIKQ*" /label="yxlD CDS" gene complement(3587051..3587257) /gene="yxlD" /locus_tag="BSU_38680" /old_locus_tag="BSU38680" /label="yxlD gene" CDS complement(3587254..3587574) /gene="yxlC" /locus_tag="BSU_38690" /old_locus_tag="BSU38690" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12897008, 14769884, 14993308" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12897008, 14769884, 14993308; Product type r: regulator" /codon_start=1 /transl_table=11 /product="sigma-Y antisigma factor" /protein_id="NP_391748.1" /db_xref="EnsemblGenomes-Gn:BSU38690" /db_xref="EnsemblGenomes-Tr:CAB15895" /db_xref="GOA:P94371" /db_xref="InterPro:IPR035238" /db_xref="SubtiList:BG12549" /db_xref="UniProtKB/Swiss-Prot:P94371" /translation="MNKEKLSDHLKSEWKKIDQTANPSIPNQKELLHQLSQMKAEYRK KLLQEIILFVFCALMVVSAAILAFTQAPAVFIVLQVCVLAVLPILIAAEKKRHLGECE VKRG*" /label="yxlC CDS" gene complement(3587254..3587574) /gene="yxlC" /locus_tag="BSU_38690" /old_locus_tag="BSU38690" /label="yxlC gene" promotor_-35 3587387..3587396 /Source="Nicolas_upshift_promotors" /id="U3044" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1366 /SigmaFactorBS="aacacagcaggagcttgagtgaaagctaagattgcaGCACTC ACAAccatcagcgcgcAGAATACAAATAAAATGATCtcttgaagaagtttttttctgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3587409..3587428 /Source="Nicolas_upshift_promotors" /id="U3044" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1366 /SigmaFactorBS="aacacagcaggagcttgagtgaaagctaagattgcaGCACTC ACAAccatcagcgcgcAGAATACAAATAAAATGATCtcttgaagaagtttttttctgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3587411 /Source="Nicolas_upshifts" /id="U3044" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1366 /SigmaFactorBS="aacacagcaggagcttgagtgaaagctaagattgcaGCACTC ACAAccatcagcgcgcAGAATACAAATAAAATGATCtcttgaagaagtttttttctgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3587567..3588103) /gene="sigY" /locus_tag="BSU_38700" /old_locus_tag="BSU38700" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12897008, 14769884, 14993308" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12897008, 14769884, 14993308; Product type r: regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase ECF (extracytoplasmic function)-type sigma factor (sigma-Y)" /protein_id="NP_391749.1" /db_xref="EnsemblGenomes-Gn:BSU38700" /db_xref="EnsemblGenomes-Tr:CAB15896" /db_xref="GOA:P94370" /db_xref="InterPro:IPR000838" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11975" /db_xref="UniProtKB/Swiss-Prot:P94370" /translation="MDTQEEQRLIQQAKEGNDEAFTALFHYHYSFLYKYLLKLSLHPD LSEELVQETFLKGYIHLRSFQGRSKFSTWLISIASRLYLDHQKKRKREWKRNQTVTEE TIRKIKWDVSAKGAEWSETLDLFSKLDPKLRTPVLLRHYYGYTYAEIGVMLQIKEGTV KSRVHKGLQQIRKEWDDE*" /label="sigY CDS" gene complement(3587567..3588103) /gene="sigY" /locus_tag="BSU_38700" /old_locus_tag="BSU38700" /label="sigY gene" upshifts complement(3588131) /Source="Nicolas_upshifts" /id="U3045" /multdbtbs="SigY" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1710 /SigmaFactorBS="gctgaaaagaattgtaaaaaagaTGAACGCTTTtgaatccgg tgTCGTCTCATAAGGCAGaaaaacaaaaaaggggggatcacggtcattggatacacaa g" /listShort="sigY, yxlC, yxlD, yxlE, yxlF, yxlG, S1484, S1483, S1482" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3588132..3588147) /Source="Nicolas_upshift_promotors" /id="U3045" /multdbtbs="SigY" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1710 /SigmaFactorBS="gctgaaaagaattgtaaaaaagaTGAACGCTTTtgaatccgg tgTCGTCTCATAAGGCAGaaaaacaaaaaaggggggatcacggtcattggatacacaa g" /listShort="sigY, yxlC, yxlD, yxlE, yxlF, yxlG, S1484, S1483, S1482" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3588159..3588168) /Source="Nicolas_upshift_promotors" /id="U3045" /multdbtbs="SigY" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1710 /SigmaFactorBS="gctgaaaagaattgtaaaaaagaTGAACGCTTTtgaatccgg tgTCGTCTCATAAGGCAGaaaaacaaaaaaggggggatcacggtcattggatacacaa g" /listShort="sigY, yxlC, yxlD, yxlE, yxlF, yxlG, S1484, S1483, S1482" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3588234..3588241 /Source="Nicolas_upshift_promotors" /id="U3046" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.993006993006993" /xcortree=2429 /SigmaFactorBS="aggcttcccggccgtttggctgcatatcctTATTTGTAaacc cccttatagTCTGTTAAGCTATGACTTTAtgtcgatttcaaaaaaacatccaatatgg a" /listShort="yxlA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3588255..3588274 /Source="Nicolas_upshift_promotors" /id="U3046" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.993006993006993" /xcortree=2429 /SigmaFactorBS="aggcttcccggccgtttggctgcatatcctTATTTGTAaacc cccttatagTCTGTTAAGCTATGACTTTAtgtcgatttcaaaaaaacatccaatatgg a" /listShort="yxlA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3588264 /Source="Nicolas_upshifts" /id="U3046" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.993006993006993" /xcortree=2429 /SigmaFactorBS="aggcttcccggccgtttggctgcatatcctTATTTGTAaacc cccttatagTCTGTTAAGCTATGACTTTAtgtcgatttcaaaaaaacatccaatatgg a" /listShort="yxlA" /GFF_Attribute="listLong" /label="upshifts" CDS 3588315..3589688 /gene="yxlA" /locus_tag="BSU_38710" /old_locus_tag="BSU38710" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 2191181, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative purine-cytosine (pyridoxine) permease" /protein_id="NP_391750.1" /db_xref="EnsemblGenomes-Gn:BSU38710" /db_xref="EnsemblGenomes-Tr:CAB15897" /db_xref="GOA:P94369" /db_xref="InterPro:IPR001248" /db_xref="InterPro:IPR026030" /db_xref="SubtiList:BG12548" /db_xref="UniProtKB/Swiss-Prot:P94369" /translation="MKVERRTIEYIPNEERHGKAKDLFPVWFGANMHITTLVTGTIPV AMGLNLFWSVAAIICGTLIGAIFMASHSAQGPQLGIPQMIQSRAQFGVIGAILPLFLV MFIYLGFFASSTILAAGTLSSFVPIPGSWSIIGLSAVCFLLTIFGHDLIHKMQKILSW TSFAVFFAATILIFQLPIPAGSWIPGAIDLPIFLVAVSAVATWQLAYAPYVADYSRYL PVKTPASKTFWYSYAGTSVSSIWMMLLGALLTTSLPDFTANSGSQIVQLFGPFSFIML IIVLFGQMAINVFNLYGAFMSTTTTLEPFLKLKVTPKVRIIMILGVTLVGTVLSLLGQ SNFMELFLNFIFFISYFLIPWTAINLVDYYFVRHGKYQVKAMFDVNGPYGKVNWITTI AFVLSILLEIPFINTSFYIGPLAKMFGGGDIAWIIGLAVPSVLYYVLMKPRLKKRAGY QEKLSSL*" /label="yxlA CDS" gene 3588315..3589688 /gene="yxlA" /locus_tag="BSU_38710" /old_locus_tag="BSU38710" /label="yxlA gene" S_feature complement(3588595..3589137) /Source="Nicolas_S_feature" /locus_tag="new_3971340_3971882_c" /HighExp="Etha, LBGstat, T1.0H, T0.30H, Diami, T1.30H, dia15, G150, G135, G180" /AntisenseName="yxlA" /AntisenseCor="-8.6586358833710395E-2" /AntisenseRegPval="-0.8" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1485" promotor_-10 complement(3589125..3589144) /Source="Nicolas_upshift_promotors" /id="U3047" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98101898101898" /psig="0.996003996003996" /xcortree=1813 /SigmaFactorBS="aagccccatacaggttaaaaacattgattgcCATTTGCCcaa atagcacaatgATCAGCATAATAAACGAGAAgggaccgaacaattggacaatctggct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3589137) /Source="Nicolas_upshifts" /id="U3047" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98101898101898" /psig="0.996003996003996" /xcortree=1813 /SigmaFactorBS="aagccccatacaggttaaaaacattgattgcCATTTGCCcaa atagcacaatgATCAGCATAATAAACGAGAAgggaccgaacaattggacaatctggct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3589159..3589166) /Source="Nicolas_upshift_promotors" /id="U3047" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98101898101898" /psig="0.996003996003996" /xcortree=1813 /SigmaFactorBS="aagccccatacaggttaaaaacattgattgcCATTTGCCcaa atagcacaatgATCAGCATAATAAACGAGAAgggaccgaacaattggacaatctggct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3589523 /Source="Nicolas_upshifts" /id="D2006" /incds=1 /nref=30 /ntot=136 /MaxReadThrough="1.87017" /MaxDrop="3.59478" /score="22.3054019" /energy="-12.9" /TU="NA" /idTUdmin="U3046" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3589703..3590533) /gene="nnrA" /locus_tag="BSU_38720" /old_locus_tag="BSU38720" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12457846, 21994945, 22940582, 25393291" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12457846, 21994945, 22940582, 25393291; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NAD(P)H dehydratase" /protein_id="NP_391751.1" /db_xref="EnsemblGenomes-Gn:BSU38720" /db_xref="EnsemblGenomes-Tr:CAB15898" /db_xref="GOA:P94368" /db_xref="InterPro:IPR000631" /db_xref="InterPro:IPR017953" /db_xref="InterPro:IPR029056" /db_xref="PDB:1KYH" /db_xref="PDB:3RPH" /db_xref="PDB:3RPZ" /db_xref="PDB:3RQ2" /db_xref="PDB:3RQ5" /db_xref="PDB:3RQ6" /db_xref="PDB:3RQ8" /db_xref="PDB:3RQH" /db_xref="PDB:3RQQ" /db_xref="PDB:3RQX" /db_xref="SubtiList:BG12547" /db_xref="UniProtKB/Swiss-Prot:P94368" /translation="MNVPFWTEEHVRATLPERDAESHKGTYGTALLLAGSDDMPGAAL LAGLGAMRSGLGKLVIGTSENVIPLIVPVLPEATYWRDGWKKAADAQLEETYRAIAIG PGLPQTESVQQAVDHVLTADCPVILDAGALAKRTYPKREGPVILTPHPGEFFRMTGVP VNELQKKRAEYAKEWAAQLQTVIVLKGNQTVIAFPDGDCWLNPTGNGALAKGGTGDTL TGMILGMLCCHEDPKHAVLNAVYLHGACAELWTDEHSAHTLLAHELSDILPRVWKRFE *" /label="nnrA CDS" gene complement(3589703..3590533) /gene="nnrA" /locus_tag="BSU_38720" /old_locus_tag="BSU38720" /label="nnrA gene" downshifts complement(3589709) /Source="Nicolas_upshifts" /id="D2007" /incds=0 /nref=3 /ntot=52 /MaxReadThrough="3.50755" /MaxDrop="3.84264" /score="7.61210868" /energy="-12.9" /TU="U3048" /idTUdmin="U3051" /TUdmin=792 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3590552..3590570) /Source="Nicolas_upshift_promotors" /id="U3048" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=168 /SigmaFactorBS="gtaaaataaaagacagccctaaaaggctgtctttttTGTTTG AaaaagaaaagggacAGGAAAAATAGGAAAAGAAagcagaggagggatagagatgaat g" /listShort="yxkO, S1485" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3590567) /Source="Nicolas_upshifts" /id="U3048" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=168 /SigmaFactorBS="gtaaaataaaagacagccctaaaaggctgtctttttTGTTTG AaaaagaaaagggacAGGAAAAATAGGAAAAGAAagcagaggagggatagagatgaat g" /listShort="yxkO, S1485" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3590585..3590591) /Source="Nicolas_upshift_promotors" /id="U3048" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=168 /SigmaFactorBS="gtaaaataaaagacagccctaaaaggctgtctttttTGTTTG AaaaagaaaagggacAGGAAAAATAGGAAAAGAAagcagaggagggatagagatgaat g" /listShort="yxkO, S1485" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3590611) /Source="Nicolas_upshifts" /id="U3049" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.973026973026973" /psig="0.98101898101898" /xcortree=2119 /SigmaFactorBS="cggcaaacgaacgatatcgccgcctgtatcaccttgatgTTC CTGTAAAATAAAAGACAgccctaaaaggctgtcttttttgtttgaaaaagaaaaggga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(3590613..3590632) /Source="Nicolas_upshift_promotors" /id="U3049" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.973026973026973" /psig="0.98101898101898" /xcortree=2119 /SigmaFactorBS="cggcaaacgaacgatatcgccgcctgtatcaccttgatgTTC CTGTAAAATAAAAGACAgccctaaaaggctgtcttttttgtttgaaaaagaaaaggga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(3590619..3592346) /gene="cydD" /locus_tag="BSU_38730" /old_locus_tag="BSU38730" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9852001, 10551842, 15231791, 16040611, 26517902, 26699904; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC membrane transporter (ATP-binding protein) required for cytochrome bb' function (reductant efflux pump)" /protein_id="NP_391752.1" /db_xref="EnsemblGenomes-Gn:BSU38730" /db_xref="EnsemblGenomes-Tr:CAB15899" /db_xref="GOA:P94367" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR014223" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG11928" /db_xref="UniProtKB/Swiss-Prot:P94367" /translation="MKKEEWILPYIKQNARLFVLVIFLGAVTIFSAAFLMFTSGFLIS KAATRPENILLIYVPIVAVRTFGIARSVSRYVERLVGHHIILKIVSDMRVRLYNMLEP GALMLRSRFRTGDMLGILSEDIEHLQDAFLKTIFPAISALLLYAVSVIALGFFSWPFA ILLALYLFVLVVLFPVVSLLVTRAKNAKLKSGRNVLYSRLTDAVMGVSDWMFSGRRHA FIDAYEKEERDWFELERKKQRFTRWRDFAAQCLVAGLILLMLFWTAGQQADGELAKTM IAAFVLVVFPLTEAFLPLSDALGEVPGYQDSIRRMNNVAPQPEASQTESGDQILDLQD VTLAFRDVTFSYDNSSQVLHNFSFTLRQGEKMALLGRSGSGKSTSLALIEGALKPDSG SVTLNGVETALLKDQIADAVAVLNQKPHLFDTSILNNIRLGNGEASDEDVRRAAKQVK LHDYIESLPDGYHTSVQETGIRFSGGERQRIALARILLQDTPIIILDEPTVGLDPITE RELMETVFEVLKGKTILWITHHLAGVEAADKIVFLENGKTEMEGTHEELLAANERYRR LYHLDVPVK*" /label="cydD CDS" gene complement(3590619..3592346) /gene="cydD" /locus_tag="BSU_38730" /old_locus_tag="BSU38730" /label="cydD gene" downshifts complement(3590718) /Source="Nicolas_upshifts" /id="D2008" /incds=1 /nref=7 /ntot=46 /MaxReadThrough="5.39758" /MaxDrop="3.66431" /score="25.0271963" /energy="-10.6" /TU="U3051" /idTUdmin="U3051" /TUdmin="-217" /isTUend="FALSE" /label="downshifts" CDS complement(3592343..3594046) /gene="cydC" /locus_tag="BSU_38740" /old_locus_tag="BSU38740" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9852001, 10551842, 15231791, 16040611, 26517902, 26699904; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC membrane transporter (ATP-binding protein) required for cytochrome bb' function (reductant efflux pump)" /protein_id="NP_391753.1" /db_xref="EnsemblGenomes-Gn:BSU38740" /db_xref="EnsemblGenomes-Tr:CAB15900" /db_xref="GOA:P94366" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR014216" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG11927" /db_xref="UniProtKB/Swiss-Prot:P94366" /translation="MGKDLFRYKGMKRILTLITCLTLIQTAAIIMQAEWLSEAVTGLF NGKGITSLLPVIGFFLIAFIARHGMTVARQKIVYQYAARTGADLRKSFLDQLFRLGPR FAKKEGTGQMVTLAMEGISQFRRYLELFLPKMVSMAIVPAAVVIYVFFQDRTSAIILV AAMPILIIFMILLGLVAQRKADRQWKSYQRLSNHFVDSLRGLETLRFLGLSKSHSKNI FYVSERYRKATMSTLRVAFLSSFALDFFTMLSVATVAVFLGLRLIDGDILLGPALTAL ILAPEYFLPVREVGNDYHATLNGQEAGKTIQEILSQPGFKEETPLQLEAWSDQDELKL SGVSVGRSVSDIHLSFKGKKKIGIIGASGAGKSTLIDILGGFLEPDGGMIEVNGTSRS HLQDGSWQKNLLYIPQHPYIFDDTLGNNIRFYHPSASAEDTTRAAASAGLTELVNNLP DGLEGRIGEGGRALSGGQAQRVALARAFLGNRPILLLDEPTAHLDIETEYEIKETMLD LFEDKLVFLATHRLHWMLDMDEIIVLDGGRVAEIGTHNELLEKNGVYTKLVKAQLGER A*" /label="cydC CDS" gene complement(3592343..3594046) /gene="cydC" /locus_tag="BSU_38740" /old_locus_tag="BSU38740" /label="cydC gene" CDS complement(3594046..3595062) /gene="cydB" /locus_tag="BSU_38750" /old_locus_tag="BSU38750" /EC_number="1.10.3.-" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:9852001, 10551842, 15231791, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9852001, 10551842, 15231791, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome bb' ubiquinol oxidase (subunit II)" /protein_id="NP_391754.1" /db_xref="EnsemblGenomes-Gn:BSU38750" /db_xref="EnsemblGenomes-Tr:CAB15901" /db_xref="GOA:P94365" /db_xref="InterPro:IPR003317" /db_xref="SubtiList:BG11926" /db_xref="UniProtKB/Swiss-Prot:P94365" /translation="MASLHDLWFILVAVLFVGFFFLEGFDFGVGMATRFLGHNELERR VLINTIGPFWDANEVWLLTGAGAIFAAFPNWYATMLSGYYIPFVIVLLALMGRGVAFE FRGKVDHLKWVKVWDWVVFFGSLIPPFVLGVLFTTLFRGMPIDADMNIHAHVSDYINV YSILGGVTVTLLCFQHGLMFITLRTIGDLQNRARKMAQKIMGVVFVAVLAFAALSAYQ TDMFTRRGEITIPLAVLIVICFMLAAVFIRKKKDGWTFGMTGAGLALTVGMIFISLFP RVMVSSLHSAYDLTVANASSGDYSLKVMSIAALTLLPFVIGSQIWSYYVFRKRVSHKE PMTY*" /label="cydB CDS" gene complement(3594046..3595062) /gene="cydB" /locus_tag="BSU_38750" /old_locus_tag="BSU38750" /label="cydB gene" promotor_-10 complement(3594936..3594954) /Source="Nicolas_upshift_promotors" /id="U3050" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.963036963036963" /psig="0.963036963036963" /xcortree=1107 /SigmaFactorBS="ttctttttggaaggctttgatttcggggtcGGCATGgcgacc cgttttcttGGCCATAATGAATTAGAACgcagagtgctgatcaacacgatcgggccgt t" /listShort="cydC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3594945) /Source="Nicolas_upshifts" /id="U3050" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.963036963036963" /psig="0.963036963036963" /xcortree=1107 /SigmaFactorBS="ttctttttggaaggctttgatttcggggtcGGCATGgcgacc cgttttcttGGCCATAATGAATTAGAACgcagagtgctgatcaacacgatcgggccgt t" /listShort="cydC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3594970..3594975) /Source="Nicolas_upshift_promotors" /id="U3050" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.963036963036963" /psig="0.963036963036963" /xcortree=1107 /SigmaFactorBS="ttctttttggaaggctttgatttcggggtcGGCATGgcgacc cgttttcttGGCCATAATGAATTAGAACgcagagtgctgatcaacacgatcgggccgt t" /listShort="cydC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3595046..3596452) /gene="cydA" /locus_tag="BSU_38760" /old_locus_tag="BSU38760" /EC_number="1.10.3.-" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:9852001, 10551842, 15231791, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9852001, 10551842, 15231791, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome bb' ubiquinol oxidase (subunit I)" /protein_id="NP_391755.1" /db_xref="EnsemblGenomes-Gn:BSU38760" /db_xref="EnsemblGenomes-Tr:CAB15902" /db_xref="GOA:P94364" /db_xref="InterPro:IPR002585" /db_xref="SubtiList:BG11925" /db_xref="UniProtKB/Swiss-Prot:P94364" /translation="MSELVLARIQFASTTLFHFLFVPMSIGLVFMVALMETLYLVKKN ELYLKMAKFWGHLFLINFAVGVVTGILQEFQFGLNWSDYSRFVGDVFGAPLAIEALLA FFMESIFIGLWIFGWDRLPKKIHALCIWLVSFGTIMSSFWILTANSFMQEPVGFTIKN GRAEMNDFGALITNPQLWVEFPHVIFGALATGAFFIAGVSAFKLLKKKEVPFFKQSFK LAMIVGLCAGLGVGLSGHMQAEHLMESQPMKMAASEGLWEDSGDPAAWTAFATIDTKN EKSSNEIKVPYALSYLAYQKFSGSVKGMKTLQAEYEKIYGKGDYIPPVKTTFWSFRIM VGAGVVMILAALGGLWLNRRKKLENSKWYLRIMIALISFPFLANSAGWIMTEIGRQPW TVMGLMTTAQSVSPNVTAGSLLFSIIAFGVMYMILGALLVFLFIREIKKGAEHDNHHD VPVSTDPFSQEVYHGISS*" /label="cydA CDS" gene complement(3595046..3596452) /gene="cydA" /locus_tag="BSU_38760" /old_locus_tag="BSU38760" /label="cydA gene" S_feature complement(3596453..3596661) /Source="Nicolas_S_feature" /locus_tag="new_3979198_3979406_c" /HighExp="M0t45, ferm, UNK1, Gly, Lbexp, Lbstat, dia0, nit, M/G, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1486" promotor_-10 complement(3596644..3596663) /Source="Nicolas_upshift_promotors" /id="U3051" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.276723276723277" /psig="0.999000999001" /xcortree=1601 /SigmaFactorBS="aatccgtcacatagtgcgggactttttaggtattttaggCTT TATttttgaaatgaatCGTTGTAAAGTACTTAATATgaaccagtcagagattgtgtca t" /listShort="S1486, cydA, cydB, cydC, cydD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3596661) /Source="Nicolas_upshifts" /id="U3051" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.276723276723277" /psig="0.999000999001" /xcortree=1601 /SigmaFactorBS="aatccgtcacatagtgcgggactttttaggtattttaggCTT TATttttgaaatgaatCGTTGTAAAGTACTTAATATgaaccagtcagagattgtgtca t" /listShort="S1486, cydA, cydB, cydC, cydD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3596663..3596771) /Source="Nicolas_S_feature" /locus_tag="new_3979408_3979516_c" /HighExp="LPhT, LBGtran, ferm, LBGstat, M0t45, dia0, Etha, dia5, Lbexp, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1487" promotor_-35 complement(3596677..3596682) /Source="Nicolas_upshift_promotors" /id="U3051" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.276723276723277" /psig="0.999000999001" /xcortree=1601 /SigmaFactorBS="aatccgtcacatagtgcgggactttttaggtattttaggCTT TATttttgaaatgaatCGTTGTAAAGTACTTAATATgaaccagtcagagattgtgtca t" /listShort="S1486, cydA, cydB, cydC, cydD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3596768..3596787) /Source="Nicolas_upshift_promotors" /id="U3052" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.713286713286713" /psig="0.996003996003996" /xcortree=1598 /SigmaFactorBS="ctgagactcgagtgctggggcgggggcaagcatttTGTTCGC AaggaacgatgtgtTGATGTACGATAATAAAGGGtcatttatcctagcagccgacata a" /listShort="S1487, S1486, cydA" /listLong="cydB, cydC, cydD" /label="promotor_-10" upshifts complement(3596783) /Source="Nicolas_upshifts" /id="U3052" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.713286713286713" /psig="0.996003996003996" /xcortree=1598 /SigmaFactorBS="ctgagactcgagtgctggggcgggggcaagcatttTGTTCGC AaggaacgatgtgtTGATGTACGATAATAAAGGGtcatttatcctagcagccgacata a" /listShort="S1487, S1486, cydA" /listLong="cydB, cydC, cydD" /label="upshifts" promotor_-35 complement(3596801..3596808) /Source="Nicolas_upshift_promotors" /id="U3052" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.713286713286713" /psig="0.996003996003996" /xcortree=1598 /SigmaFactorBS="ctgagactcgagtgctggggcgggggcaagcatttTGTTCGC AaggaacgatgtgtTGATGTACGATAATAAAGGGtcatttatcctagcagccgacata a" /listShort="S1487, S1486, cydA" /listLong="cydB, cydC, cydD" /label="promotor_-35" promotor_-35 3596929..3596936 /Source="Nicolas_upshift_promotors" /id="U3053" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.65034965034965" /psig="0.997002997002997" /xcortree=400 /SigmaFactorBS="tttgaaccggtaagaggagaaaagttgaatagtaaattttta aTATATTAAtaatttcaatttttTAGTATACTTAACATAGTGaacaatttcactgcat c" /listShort="cimH, yxkI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3596946 /Source="Nicolas_upshifts" /id="U3053" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.65034965034965" /psig="0.997002997002997" /xcortree=400 /SigmaFactorBS="tttgaaccggtaagaggagaaaagttgaatagtaaattttta aTATATTAAtaatttcaatttttTAGTATACTTAACATAGTGaacaatttcactgcat c" /listShort="cimH, yxkI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3596951..3596969 /Source="Nicolas_upshift_promotors" /id="U3053" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.65034965034965" /psig="0.997002997002997" /xcortree=400 /SigmaFactorBS="tttgaaccggtaagaggagaaaagttgaatagtaaattttta aTATATTAAtaatttcaatttttTAGTATACTTAACATAGTGaacaatttcactgcat c" /listShort="cimH, yxkI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3597008..3598360 /gene="cimH" /locus_tag="BSU_38770" /old_locus_tag="BSU38770" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11566984, 12525174, 15849754, 16850406, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11566984, 12525174, 15849754, 16850406, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="citrate/malate/H+ symporter" /protein_id="NP_391756.1" /db_xref="EnsemblGenomes-Gn:BSU38770" /db_xref="EnsemblGenomes-Tr:CAB15903" /db_xref="GOA:P94363" /db_xref="InterPro:IPR004679" /db_xref="InterPro:IPR018025" /db_xref="SubtiList:BG12546" /db_xref="UniProtKB/Swiss-Prot:P94363" /translation="MGELQTHMQLQTDTIHEGVRKENWFAKAMNIKVGIIPLPVYALL FILITVFVMHHDVKSDILTSIAVMAFFGFTFAQIGKSIPIVRSIGGPAILATFIPSAV VYYHLLPNDIVKSTTEFTENSNFLYLFIAGIVVGSILGMKRETLVKAFMKIFIPLIVG SVTAAIVGLAVGTLLGLGFQHTLLYIVIPIMAGGVGEGAIPLSIGYSDIMPISQGEAF ALVLPSIMLGSLCAIILAGLLNRIGKKKPEWTGNGKVDRSEEESPALEESQSGQQMFN LSLFASGGILAVSLYLVGMLAHDFFGFPAPVAMLLLAVLIKLFRLVPASIENGAFGVS RFFSTAVTYPLLFAIGVSMTPWDKLVAAFNLSNIITILSVVVTMMAVGFFTGKWLNMY PIETAIINACHSGQGGTGDVAILSAAERLELMPFAQVSTRIGGAITVSLTLLLLHQFY *" /label="cimH CDS" gene 3597008..3598360 /gene="cimH" /locus_tag="BSU_38770" /old_locus_tag="BSU38770" /label="cimH gene" S_feature complement(3597959..3600441) /Source="Nicolas_S_feature" /locus_tag="new_3980704_3983186_c" /HighExp="Cold, C30, LBGstat, Paraq, GM 120, GM 90, H2O2, Oxctl, GM 25, GM 45" /AntisenseName="yxkI" /AntisenseCor="0.564471040461903" /AntisenseRegPval="-23.3" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1488" downshifts 3598345 /Source="Nicolas_upshifts" /id="D2009" /incds=0 /nref=63 /ntot=147 /MaxReadThrough="2.93791" /MaxDrop="3.97692" /score="3.68725156" /energy="-12.7" /TU="U3053" /idTUdmin="U3053" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" misc_feature 3598436..3598455 /Source="Nicolas_upshift_promotors" /id="U3054" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=2291 /SigmaFactorBS="tcaaacgaaagagcttgcttttttgcatgtccatgtttttgc aagttcccatccCATGCTATAGTAATAGTTGGaaatactagatagaaaggaatctggc a" /listShort="yxkI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3598442 /Source="Nicolas_upshifts" /id="U3054" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=2291 /SigmaFactorBS="tcaaacgaaagagcttgcttttttgcatgtccatgtttttgc aagttcccatccCATGCTATAGTAATAGTTGGaaatactagatagaaaggaatctggc a" /listShort="yxkI" /GFF_Attribute="listLong" /label="upshifts" CDS 3598482..3600170 /gene="yxkI" /locus_tag="BSU_38780" /old_locus_tag="BSU38780" /EC_number="3.4.24.-" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16845009; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane protease" /protein_id="NP_391757.1" /db_xref="EnsemblGenomes-Gn:BSU38780" /db_xref="EnsemblGenomes-Tr:CAB15904" /db_xref="GOA:P94362" /db_xref="InterPro:IPR001915" /db_xref="SubtiList:BG12545" /db_xref="UniProtKB/Swiss-Prot:P94362" /translation="MPMGTHLFLFMLLGLGFYLISALAAKLIPAIDFWIDIVLWVGAA AYIFSHLSFMDGIVSLATMFYCYWTAMDLIVSERVEKPSGDWQEIELAKNKTRLLSDI TLTAIVFAGAVIFFIYGPDTSPLKYVILLGMISGGGALVKRILNVFSVKVFYSAALEK LHISSHYETRTYPLSDLKNIQLESTADLLKLHPLLTMYSSRLDLTTSFQQVIKLSLPG ETLFLTVKEPQKWKTILQEYTDAENNVDNVISVLPFYHRKNVKRLLGKLYFAASVKGV SAYALLVLALYALHASPWVMAVAVILYWVFNMYMSDRVLRAAMDAKSCHHPHVQAAAD KIFRSAGISHVRIYETESDDYNGMAVGMNVGRSMVILTSATLTLPQRVIEGILAHEAI HIKKRDVLSSQLLRFLYLGAVVGIFLLFEQHITHPEAHKIALWAFIMAIIILFQLYQS FCSQWMEVRADNLGASLLDGGYKQMAEALRILAVRQDEDIQKQSAYSSEAGEDELQID SLTRDKSWFFRLIDFQFAPHPPMYWRVGTLLSNKGHGVLKRWLRDRLKESITLK*" /label="yxkI CDS" gene 3598482..3600170 /gene="yxkI" /locus_tag="BSU_38780" /old_locus_tag="BSU38780" /label="yxkI gene" promotor_-35 3600168..3600177 /Source="Nicolas_upshift_promotors" /id="U3055" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1699 /SigmaFactorBS="tcagagaccgactgaaagaatcgatcactttgaaaTGAAACC GGTcagcgtttcatCCGTATAACAGATATGgtgaaaaaagggagtgacgcgaagtgat t" /listShort="yxzE, S1489" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3600189..3600204 /Source="Nicolas_upshift_promotors" /id="U3055" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1699 /SigmaFactorBS="tcagagaccgactgaaagaatcgatcactttgaaaTGAAACC GGTcagcgtttcatCCGTATAACAGATATGgtgaaaaaagggagtgacgcgaagtgat t" /listShort="yxzE, S1489" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3600193 /Source="Nicolas_upshifts" /id="U3055" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1699 /SigmaFactorBS="tcagagaccgactgaaagaatcgatcactttgaaaTGAAACC GGTcagcgtttcatCCGTATAACAGATATGgtgaaaaaagggagtgacgcgaagtgat t" /listShort="yxzE, S1489" /GFF_Attribute="listLong" /label="upshifts" CDS 3600228..3600428 /gene="yxzE" /locus_tag="BSU_38790" /old_locus_tag="BSU38790" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16845009; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative bacteriocin" /protein_id="NP_391758.1" /db_xref="EnsemblGenomes-Gn:BSU38790" /db_xref="EnsemblGenomes-Tr:CAB15905" /db_xref="SubtiList:BG14168" /db_xref="UniProtKB/Swiss-Prot:O32284" /translation="MIVIILLFISIIVFLSVIQPQPSKNKSRQQADSGYFGYSDHSSH HDGCSSDGGFSDSGCGGGGGGD*" /label="yxzE CDS" gene 3600228..3600428 /gene="yxzE" /locus_tag="BSU_38790" /old_locus_tag="BSU38790" /label="yxzE gene" S_feature 3600429..3601373 /Source="Nicolas_S_feature" /locus_tag="new_3983174_3984118" /HighExp="T0.30H, T1.0H, T1.30H, T2.0H, T2.30H, T0.0H, T-0.40H, Salt, T3.30H, T3.0H" /AntisenseName="yxkH" /AntisenseCor="0.147753218660366" /AntisenseRegPval="-1.8" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1489" CDS complement(3600442..3601281) /gene="yxkH" /locus_tag="BSU_38800" /old_locus_tag="BSU38800" /EC_number="3.-.-.-" /function="16.8: Protect" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22277649; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative exported polysaccharide deacetylase, lipoprotein" /protein_id="NP_391759.1" /db_xref="EnsemblGenomes-Gn:BSU38800" /db_xref="EnsemblGenomes-Tr:CAB15906" /db_xref="GOA:P94361" /db_xref="InterPro:IPR002509" /db_xref="InterPro:IPR011330" /db_xref="SubtiList:BG12544" /db_xref="UniProtKB/Swiss-Prot:P94361" /translation="MKRLFLSIFLLGSCLALAACADQEANAEQPMPKAEQKKPEKKAV QVQKKEDDTSAWIKTEKPAKLPILMYHSISSGNSLRVPKKEFEAHMKWLHDNGYQTLT PKEASLMLTQDKKPSEKCVLITFDDGYTDNYQDAYPVLKKYGMKATIFMIGKSIGHKH HLTEEQMKEMAQHGISIESHTIDHLELNGLTPQQQQSEMADSKKLFDNMFHQQTTIIS YPVGRYNEETLKAAEKTGYQMGVTTEPGAASRDQGMYALHRVRVSPGMSGSAFGAYIE SMK*" /label="yxkH CDS" gene complement(3600442..3601281) /gene="yxkH" /locus_tag="BSU_38800" /old_locus_tag="BSU38800" /label="yxkH gene" promotor_-10 complement(3601307..3601325) /Source="Nicolas_upshift_promotors" /id="U3056" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2813 /SigmaFactorBS="tcaaaaaaaccggacatggagacatgtccggttttttgctAT TGAAAAtctcagaatcaaACCGATGAAAAAGGAGGAAgaaatagacagaaagcaggag a" /listShort="yxkH, S1488" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3601325) /Source="Nicolas_upshifts" /id="U3056" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2813 /SigmaFactorBS="tcaaaaaaaccggacatggagacatgtccggttttttgctAT TGAAAAtctcagaatcaaACCGATGAAAAAGGAGGAAgaaatagacagaaagcaggag a" /listShort="yxkH, S1488" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3601338..3601345) /Source="Nicolas_upshift_promotors" /id="U3056" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2813 /SigmaFactorBS="tcaaaaaaaccggacatggagacatgtccggttttttgctAT TGAAAAtctcagaatcaaACCGATGAAAAAGGAGGAAgaaatagacagaaagcaggag a" /listShort="yxkH, S1488" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3601340 /Source="Nicolas_upshifts" /id="D2010" /incds=0 /nref=27 /ntot=142 /MaxReadThrough="0.40982" /MaxDrop="6.50242" /score="33.6694147" /energy="-13.4" /TU="NA" /idTUdmin="U3055" /TUdmin=3 /isTUend="TRUE" /label="downshifts" CDS complement(3601388..3602485) /gene="msmX" /locus_tag="BSU_38810" /old_locus_tag="BSU38810" /EC_number="3.6.3.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16707683" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16707683; Product type t: transporter" /codon_start=1 /transl_table=11 /product="multiple sugar (maltodextrins) transporter ATP-binding protein" /protein_id="NP_391760.1" /db_xref="EnsemblGenomes-Gn:BSU38810" /db_xref="EnsemblGenomes-Tr:CAB15907" /db_xref="GOA:P94360" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005116" /db_xref="InterPro:IPR008995" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11954" /db_xref="UniProtKB/Swiss-Prot:P94360" /translation="MAELRMEHIYKFYDQKEPAVDDFNLHIADKEFIVFVGPSGCGKS TTLRMVAGLEEISKGDFYIEGKRVNDVAPKDRDIAMVFQNYALYPHMTVYDNIAFGLK LRKMPKPEIKKRVEEAAKILGLEEYLHRKPKALSGGQRQRVALGRAIVRDAKVFLMDE PLSNLDAKLRVQMRAEIIKLHQRLQTTTIYVTHDQTEALTMATRIVVMKDGKIQQIGT PKDVYEFPENVFVGGFIGSPAMNFFKGKLTDGLIKIGSAALTVPEGKMKVLREKGYIG KEVIFGIRPEDIHDELIVVESYKNSSIKAKINVAELLGSEIMIYSQIDNQDFIARIDA RLDIQSGDELTVAFDMNKGHFFDSETEVRIR*" /label="msmX CDS" gene complement(3601388..3602485) /gene="msmX" /locus_tag="BSU_38810" /old_locus_tag="BSU38810" /label="msmX gene" downshifts complement(3601389) /Source="Nicolas_upshifts" /id="D2011" /incds=0 /nref=81 /ntot=171 /MaxReadThrough="3.31232" /MaxDrop="7.04855" /score="29.2689404" /energy="-14.4" /TU="U3057" /idTUdmin="U3058" /TUdmin=2 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3602518..3602537) /Source="Nicolas_upshift_promotors" /id="U3057" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.549450549450549" /psig="0.998001998001998" /xcortree=355 /SigmaFactorBS="tgcacgaaaaatggctgggtgattttatgaacgctgccCATT TTAGcgagagggaattGCTGTTACACTCAATATAAGaaagcgtttacaataacaaagg g" /listShort="msmX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3602535) /Source="Nicolas_upshifts" /id="U3057" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.549450549450549" /psig="0.998001998001998" /xcortree=355 /SigmaFactorBS="tgcacgaaaaatggctgggtgattttatgaacgctgccCATT TTAGcgagagggaattGCTGTTACACTCAATATAAGaaagcgtttacaataacaaagg g" /listShort="msmX" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3602537..3602605) /Source="Nicolas_S_feature" /locus_tag="new_3985282_3985350_c" /HighExp="M0t90, M40t90, Lbstat, Lbtran, T2.0H, dia5, T2.30H, M9-stat, S2, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1490" promotor_-35 complement(3602550..3602557) /Source="Nicolas_upshift_promotors" /id="U3057" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.549450549450549" /psig="0.998001998001998" /xcortree=355 /SigmaFactorBS="tgcacgaaaaatggctgggtgattttatgaacgctgccCATT TTAGcgagagggaattGCTGTTACACTCAATATAAGaaagcgtttacaataacaaagg g" /listShort="msmX" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3602606..3603499) /gene="yxkF" /locus_tag="BSU_38820" /old_locus_tag="BSU38820" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10746760" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10746760; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (regulates yxkF-msmX expression)" /protein_id="NP_391761.1" /db_xref="EnsemblGenomes-Gn:BSU38820" /db_xref="EnsemblGenomes-Tr:CAB15908" /db_xref="InterPro:IPR025736" /db_xref="SubtiList:BG12543" /db_xref="UniProtKB/Swiss-Prot:P94359" /translation="MKSLLAIYPGSIVSEELCIREGCLCFFDESNQRYISIPKTEISE KEVLVLQSFLTPADEGNQLSMKSPEENKWFSFLFSRGELPAYIKKRTRFVHFHLFGKI ERTSFTEAVRHFWPVSFVIVWIHEDRGVIVEQESEAAAEKDELESLAKVLESDFYFSV RFYAGRFYEPDECLRKHYAREQAYFLFAEKRLPQVQSVTFEMIFPFLLLETEKEKLET LLSEEAELLFGSESELRKTIKLFIENNSNVTLTAKKLHLHRNSLQYRIDKFIERSGID IKSYKGALLAYFICLQNESSE*" /label="yxkF CDS" gene complement(3602606..3603499) /gene="yxkF" /locus_tag="BSU_38820" /old_locus_tag="BSU38820" /label="yxkF gene" promotor_-10 complement(3603526..3603545) /Source="Nicolas_upshift_promotors" /id="U3058" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=3179 /SigmaFactorBS="ttcagtttctcgtctatctataccggatatactctttttTAG TGGAGaacatgtgtgtttCGCCTTATACTGAATATACAgatccttacataagagagga g" /listShort="yxkF, S1490, msmX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3603545) /Source="Nicolas_upshifts" /id="U3058" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=3179 /SigmaFactorBS="ttcagtttctcgtctatctataccggatatactctttttTAG TGGAGaacatgtgtgtttCGCCTTATACTGAATATACAgatccttacataagagagga g" /listShort="yxkF, S1490, msmX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3603559..3603566) /Source="Nicolas_upshift_promotors" /id="U3058" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=3179 /SigmaFactorBS="ttcagtttctcgtctatctataccggatatactctttttTAG TGGAGaacatgtgtgtttCGCCTTATACTGAATATACAgatccttacataagagagga g" /listShort="yxkF, S1490, msmX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3603573..3603578 /Source="Nicolas_upshift_promotors" /id="U3059" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.93006993006993" /psig="0.93006993006993" /xcortree=1025 /SigmaFactorBS="gcgaaacacacatgttctccactaaaaaagAGTATAtccggt atagatagaCGAGAAACTGAAAGGGAAAcctcattcgtttacatattggcttcagcgg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3603594..3603612 /Source="Nicolas_upshift_promotors" /id="U3059" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.93006993006993" /psig="0.93006993006993" /xcortree=1025 /SigmaFactorBS="gcgaaacacacatgttctccactaaaaaagAGTATAtccggt atagatagaCGAGAAACTGAAAGGGAAAcctcattcgtttacatattggcttcagcgg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3603603 /Source="Nicolas_upshifts" /id="U3059" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.93006993006993" /psig="0.93006993006993" /xcortree=1025 /SigmaFactorBS="gcgaaacacacatgttctccactaaaaaagAGTATAtccggt atagatagaCGAGAAACTGAAAGGGAAAcctcattcgtttacatattggcttcagcgg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3603620..3603626 /Source="Nicolas_upshift_promotors" /id="U3060" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=249 /SigmaFactorBS="agatagacgagaaactgaaagggaaacctcattCGTTTACat attggcttcagcGGAAATAGAAGAAGACATGcaggaccaaaggagggtcatcttatga g" /listShort="aldY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3603641..3603659 /Source="Nicolas_upshift_promotors" /id="U3060" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=249 /SigmaFactorBS="agatagacgagaaactgaaagggaaacctcattCGTTTACat attggcttcagcGGAAATAGAAGAAGACATGcaggaccaaaggagggtcatcttatga g" /listShort="aldY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3603647 /Source="Nicolas_upshifts" /id="U3060" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=249 /SigmaFactorBS="agatagacgagaaactgaaagggaaacctcattCGTTTACat attggcttcagcGGAAATAGAAGAAGACATGcaggaccaaaggagggtcatcttatga g" /listShort="aldY" /GFF_Attribute="listLong" /label="upshifts" CDS 3603683..3605140 /gene="aldY" /locus_tag="BSU_38830" /old_locus_tag="BSU38830" /EC_number="1.2.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10482513; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aldehyde dehydrogenase" /protein_id="NP_391762.1" /db_xref="EnsemblGenomes-Gn:BSU38830" /db_xref="EnsemblGenomes-Tr:CAB15909" /db_xref="GOA:P94358" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="PDB:4DNG" /db_xref="SubtiList:BG11903" /db_xref="UniProtKB/Swiss-Prot:P94358" /translation="MSFETLNKSFINGKWTGGESGRTEDILNPYDQSVITTASLATGK QLEDAFDIAQKAQKEWAKSTTEDRKAVLQKARGYLHENRDDIIMMIARETGGTIIKST IELEQTIAILDEAMTYTGELGGVKEVPSDIEGKTNKIYRLPLGVISSISPFNFPMNLS MRSIAPAIALGNSVVHKPDIQTAISGGTIIAKAFEHAGLPAGVLNVMLTDVKEIGDGM LTNPIPRLISFTGSTAVGRHIGEIAGRAFKRMALELGGNNPFAVLSDADVDRAVDAAI FGKFIHQGQICMIINRIIVHQDVYDEFVEKFTARVKQLPYGDQTDPKTVVGPLINERQ IEKALEIIEQAKTDGIELAVEGKRVGNVLTPYVFVGADNNSKIAQTELFAPIATIIKA GSDQEAIDMANDTEYGLSSAVFTSDLEKGEKFALQIDSGMTHVNDQSVNDSPNIAFGG NKASGVGRFGNPWVVEEFTVTKWISIQKQYRKYPF*" /label="aldY CDS" gene 3603683..3605140 /gene="aldY" /locus_tag="BSU_38830" /old_locus_tag="BSU38830" /label="aldY gene" promotor_-10 complement(3604566..3604584) /Source="Nicolas_upshift_promotors" /id="U3061" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.894105894105894" /psig="0.894105894105894" /xcortree=1207 /SigmaFactorBS="gtttgatcgccgtacggaagctgtttgacacgggcggTGAAT TtttctacaaactcaTCGTATACATCTTGATGAAcgatgatcctgttgataatcatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3604581) /Source="Nicolas_upshifts" /id="U3061" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.894105894105894" /psig="0.894105894105894" /xcortree=1207 /SigmaFactorBS="gtttgatcgccgtacggaagctgtttgacacgggcggTGAAT TtttctacaaactcaTCGTATACATCTTGATGAAcgatgatcctgttgataatcatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3604599..3604604) /Source="Nicolas_upshift_promotors" /id="U3061" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.894105894105894" /psig="0.894105894105894" /xcortree=1207 /SigmaFactorBS="gtttgatcgccgtacggaagctgtttgacacgggcggTGAAT TtttctacaaactcaTCGTATACATCTTGATGAAcgatgatcctgttgataatcatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3605121 /Source="Nicolas_upshifts" /id="D2012" /incds=0 /nref=14 /ntot=39 /MaxReadThrough="1.43471" /MaxDrop="4.03346" /score="25.9343422" /energy="-13.8" /TU="NA" /idTUdmin="U3060" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 3605165 /Source="Nicolas_upshifts" /id="D2013" /incds=0 /nref=1 /ntot=1 /MaxReadThrough="1.40793" /MaxDrop="3.07407" /score="25.9343422" /energy="-13.8" /TU="NA" /idTUdmin="U3060" /TUdmin=44 /isTUend="FALSE" /label="downshifts" CDS complement(3605182..3606018) /gene="gdnE" /locus_tag="BSU_38840" /old_locus_tag="BSU38840" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10735877, 10931887, 15096624, 15849754, 16850406, 21317561; Product type t : transporter" /codon_start=1 /transl_table=11 /product="guanidinium exporter" /protein_id="NP_391763.1" /db_xref="EnsemblGenomes-Gn:BSU38840" /db_xref="EnsemblGenomes-Tr:CAB15910" /db_xref="GOA:P94357" /db_xref="InterPro:IPR003740" /db_xref="InterPro:IPR019264" /db_xref="SubtiList:BG12542" /db_xref="UniProtKB/Swiss-Prot:P94357" /translation="MKKRMLDVLMLVIGAFFFALAVNLFAIPNDLGEGGVTGITLILY YLFQWSPGVTNFILNAFLLLIGYKFLDGKTTVYTIIAVAANSLFLHLTHGWSIPSDEL IINTIFAGVFAGVGIGMIIRVGGTTAGSAILARIANKYLDWNISYALLFFDLIVVFSS YFIIGAEKMMFTIVMLYIGTKVMDFIIEGLNTKKAITVISENKSEIAEQVNTLMDRGV TILSGKGNYTGQSKEILYIVINKQELSMLKKIIRSCDKKAFVIVHDVRDVFGEGFVDI SK*" /label="gdnE CDS" gene complement(3605182..3606018) /gene="gdnE" /locus_tag="BSU_38840" /old_locus_tag="BSU38840" /label="gdnE gene" downshifts complement(3605200) /Source="Nicolas_upshifts" /id="D2014" /incds=0 /nref=19 /ntot=137 /MaxReadThrough="1.00689" /MaxDrop="4.07213" /score="21.5028874" /energy="-13.8" /TU="NA" /idTUdmin="U3062" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" misc_RNA complement(3606095..3606197) /gene="gdwB" /locus_tag="BSU_misc_RNA_60" /product="guanidine riboswitch (type I)" /experiment="publication(s) with functional evidences, PMID:21317561, 27989440, 28096518" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21317561, 27989440, 28096518" /label="gdwB RNA" gene complement(3606095..3606197) /gene="gdwB" /locus_tag="BSU_misc_RNA_60" /label="gdwB gene" downshifts complement(3606121) /Source="Nicolas_upshifts" /id="D2015" /incds=0 /nref=194 /ntot=247 /MaxReadThrough="3.21415" /MaxDrop="5.58394" /score="-0.190335837" /energy="-10.7" /TU="U3062" /idTUdmin="U3065" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3606223..3606242) /Source="Nicolas_upshift_promotors" /id="U3062" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.483516483516484" /psig="0.999000999001" /xcortree=2404 /SigmaFactorBS="ccagcttatctgatgaaaactccgcaaataccCCTTGAAcca attcgaaccgTCCCTTATAATGCTAATATTggaaagtgaaaaggatatgataaaaaca g" /listShort="NA, yxkD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3606234) /Source="Nicolas_upshifts" /id="U3062" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.483516483516484" /psig="0.999000999001" /xcortree=2404 /SigmaFactorBS="ccagcttatctgatgaaaactccgcaaataccCCTTGAAcca attcgaaccgTCCCTTATAATGCTAATATTggaaagtgaaaaggatatgataaaaaca g" /listShort="NA, yxkD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3606236..3606977) /Source="Nicolas_S_feature" /locus_tag="new_3988981_3989722_c" /HighExp="S6, S8, S7, C30, S5, Gly, C90, Fru, BT, Pyr" /AntisenseName="yxkC" /AntisenseCor="-0.38162570069976298" /AntisenseRegPval="-10" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1491" promotor_-35 complement(3606256..3606262) /Source="Nicolas_upshift_promotors" /id="U3062" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.483516483516484" /psig="0.999000999001" /xcortree=2404 /SigmaFactorBS="ccagcttatctgatgaaaactccgcaaataccCCTTGAAcca attcgaaccgTCCCTTATAATGCTAATATTggaaagtgaaaaggatatgataaaaaca g" /listShort="NA, yxkD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3606314..3606321 /Source="Nicolas_upshift_promotors" /id="U3063" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2814 /SigmaFactorBS="cagataagctggaaaaaaatacgatttatctATTAAAAAaga acagatataACCGATAAGAAAAAAAGCAtatattttacaagcgaatgtaactataaat g" /listShort="S1492, yxkC, S1493" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3606334..3606352 /Source="Nicolas_upshift_promotors" /id="U3063" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2814 /SigmaFactorBS="cagataagctggaaaaaaatacgatttatctATTAAAAAaga acagatataACCGATAAGAAAAAAAGCAtatattttacaagcgaatgtaactataaat g" /listShort="S1492, yxkC, S1493" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3606343 /Source="Nicolas_upshifts" /id="U3063" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2814 /SigmaFactorBS="cagataagctggaaaaaaatacgatttatctATTAAAAAaga acagatataACCGATAAGAAAAAAAGCAtatattttacaagcgaatgtaactataaat g" /listShort="S1492, yxkC, S1493" /GFF_Attribute="listLong" /label="upshifts" S_feature 3606353..3606438 /Source="Nicolas_S_feature" /locus_tag="new_3989098_3989183" /HighExp="Cold, SMM, MG 150, GM 90, Glu, C30, GM 150, GM-0.2, GM 15, Fru" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1492" promotor_-35 3606414..3606421 /Source="Nicolas_upshift_promotors" /id="U3064" /multdbtbs="SigD" /comp="M17" /sig="SigA" /pcomp="0.731268731268731" /psig=1 /xcortree=2816 /SigmaFactorBS="aatgataataattataagaaattcataattttatATTGACTA agagaaataatatAGGCATTATAGTACATATGTttcgtacattttattacataggagg a" /listShort="yxkC, S1493" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3606435..3606454 /Source="Nicolas_upshift_promotors" /id="U3064" /multdbtbs="SigD" /comp="M17" /sig="SigA" /pcomp="0.731268731268731" /psig=1 /xcortree=2816 /SigmaFactorBS="aatgataataattataagaaattcataattttatATTGACTA agagaaataatatAGGCATTATAGTACATATGTttcgtacattttattacataggagg a" /listShort="yxkC, S1493" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3606440 /Source="Nicolas_upshifts" /id="U3064" /multdbtbs="SigD" /comp="M17" /sig="SigA" /pcomp="0.731268731268731" /psig=1 /xcortree=2816 /SigmaFactorBS="aatgataataattataagaaattcataattttatATTGACTA agagaaataatatAGGCATTATAGTACATATGTttcgtacattttattacataggagg a" /listShort="yxkC, S1493" /GFF_Attribute="listLong" /label="upshifts" CDS 3606586..3607128 /gene="yxkC" /locus_tag="BSU_38850" /old_locus_tag="BSU38850" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12823818, 15033535" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391764.2" /db_xref="EnsemblGenomes-Gn:BSU38850" /db_xref="EnsemblGenomes-Tr:CAB15911" /db_xref="GOA:P94356" /db_xref="InterPro:IPR029050" /db_xref="InterPro:IPR029051" /db_xref="SubtiList:BG12541" /db_xref="UniProtKB/Swiss-Prot:P94356" /translation="MRHKIITFILAVVVIIIIGNMIGGGGGSEATSKTSSSSKAETEK TYNIGDTVKTEKTEVTVTKVEDRDTVGTQYVEKKASEGGTIVAVQYTIKNVSKKPISS FSIPTVKLVDADGTSYDSDIDASVNYATETKVDNSKILSDLNPNIKVTGVKAFEVDKE AYAKGTWKLKFSNDVIVKIK*" /label="yxkC CDS" gene 3606586..3607128 /gene="yxkC" /locus_tag="BSU_38850" /old_locus_tag="BSU38850" /label="yxkC gene" promotor_-10 complement(3606953..3606972) /Source="Nicolas_upshift_promotors" /id="U3065" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1368 /SigmaFactorBS="cctgttactttaatattaggatttagatcactcaaaatttta GAGTTATCAActtttgtctcagtTGCATAGTTTACAGAAGCATcaatatcagaatcat a" /listShort="S1491, NA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3606977) /Source="Nicolas_upshifts" /id="U3065" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1368 /SigmaFactorBS="cctgttactttaatattaggatttagatcactcaaaatttta GAGTTATCAActtttgtctcagtTGCATAGTTTACAGAAGCATcaatatcagaatcat a" /listShort="S1491, NA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3606986..3606995) /Source="Nicolas_upshift_promotors" /id="U3065" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1368 /SigmaFactorBS="cctgttactttaatattaggatttagatcactcaaaatttta GAGTTATCAActtttgtctcagtTGCATAGTTTACAGAAGCATcaatatcagaatcat a" /listShort="S1491, NA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3607118 /Source="Nicolas_upshifts" /id="D2016" /incds=0 /nref=78 /ntot=276 /MaxReadThrough="4.33141" /MaxDrop="6.78221" /score="9.28209494" /energy="-14.4" /TU="U3063,U3064" /idTUdmin="U3064" /TUdmin="-181" /isTUend="FALSE" /label="downshifts" S_feature 3607163..3607485 /Source="Nicolas_S_feature" /locus_tag="new_3989908_3990230" /HighExp="Cold, C30, Heat, Fru, Glu, C90, BMM, Glucon, M/G, Mal" /AntisenseName="galE" /AntisenseCor="0.165797390333391" /AntisenseRegPval="-2.2000000000000002" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1493" CDS complement(3607203..3608222) /gene="galE" /locus_tag="BSU_38860" /old_locus_tag="BSU38860" /EC_number="5.1.3.7" /EC_number="5.1.3.2" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:1906927, 9555917, 14597172" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1906927, 9555917, 14597172; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-glucose 4-epimerase" /protein_id="NP_391765.1" /db_xref="EnsemblGenomes-Gn:BSU38860" /db_xref="EnsemblGenomes-Tr:CAB15912" /db_xref="GOA:P55180" /db_xref="InterPro:IPR005886" /db_xref="InterPro:IPR008089" /db_xref="InterPro:IPR016040" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11837" /db_xref="UniProtKB/Swiss-Prot:P55180" /translation="MAILVTGGAGYIGSHTCVELLNSGYEIVVLDNLSNSSAEALNRV KEITGKDLTFYEADLLDREAVDSVFAENEIEAVIHFAGLKAVGESVAIPLKYYHNNLT GTFILCEAMEKYGVKKIVFSSSATVYGVPETSPITEDFPLGATNPYGQTKLMLEQILR DLHTADNEWSVALLRYFNPFGAHPSGRIGEDPNGIPNNLMPYVAQVAVGKLEQLSVFG NDYPTKDGTGVRDYIHVVDLAEGHVKALEKVLNSTGADAYNLGTGTGYSVLEMVKAFE KVSGKEVPYRFADRRPGDIATCFADPAKAKRELGWEAKRGLEEMCADSWRWQSSNVNG YKSAE*" /label="galE CDS" gene complement(3607203..3608222) /gene="galE" /locus_tag="BSU_38860" /old_locus_tag="BSU38860" /label="galE gene" downshifts complement(3607221) /Source="Nicolas_upshifts" /id="D2017" /incds=0 /nref=235 /ntot=261 /MaxReadThrough="1.7919" /MaxDrop="7.32805" /score="24.6899971" /energy="-14.8" /TU="NA" /idTUdmin="U3066" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3608248..3608267) /Source="Nicolas_upshift_promotors" /id="U3066" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.794205794205794" /psig="0.988011988011988" /xcortree=2154 /SigmaFactorBS="aaaaactattaataaacgattaaacttcttaaaaatgGATGt ggaccggttctaaACACTATATAATGAAAACAGgtcattttttaggagggtttacatc a" /listShort="galE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3608262) /Source="Nicolas_upshifts" /id="U3066" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.794205794205794" /psig="0.988011988011988" /xcortree=2154 /SigmaFactorBS="aaaaactattaataaacgattaaacttcttaaaaatgGATGt ggaccggttctaaACACTATATAATGAAAACAGgtcattttttaggagggtttacatc a" /listShort="galE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3608282..3608285) /Source="Nicolas_upshift_promotors" /id="U3066" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.794205794205794" /psig="0.988011988011988" /xcortree=2154 /SigmaFactorBS="aaaaactattaataaacgattaaacttcttaaaaatgGATGt ggaccggttctaaACACTATATAATGAAAACAGgtcattttttaggagggtttacatc a" /listShort="galE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3608337..3608843) /gene="yxkA" /locus_tag="BSU_38870" /old_locus_tag="BSU38870" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative phospholipid binding protein" /protein_id="NP_391766.1" /db_xref="EnsemblGenomes-Gn:BSU38870" /db_xref="EnsemblGenomes-Tr:CAB15913" /db_xref="InterPro:IPR005247" /db_xref="InterPro:IPR008914" /db_xref="InterPro:IPR036610" /db_xref="SubtiList:BG11899" /db_xref="UniProtKB/Swiss-Prot:P55185" /translation="MNIYVEANPYLHDKYSKYADEKYKREGNPFVSFPIHFDDIPSGA KTLALTFIDHDAIPVCGFSWIHWTAANIPAYIGELPEHASEERQDLMIQGQNSFASPL AGSNDPKVIHQYCGPTPPDKDHAYTLTVYALDAELNLQPGFYLNELYQEMKEHILAET SIELLARV*" /label="yxkA CDS" gene complement(3608337..3608843) /gene="yxkA" /locus_tag="BSU_38870" /old_locus_tag="BSU38870" /label="yxkA gene" promotor_-10 complement(3608849..3608868) /Source="Nicolas_upshift_promotors" /id="U3067" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=98 /SigmaFactorBS="acgtttacatgcgtatttgtttatcactgattatacatcgat tCGTTTAGtatacctatagaaCGAGAAAATAGAGAGAGGGAttcatatgaacatatac g" /listShort="yxkA, galE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3608871) /Source="Nicolas_upshifts" /id="U3067" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=98 /SigmaFactorBS="acgtttacatgcgtatttgtttatcactgattatacatcgat tCGTTTAGtatacctatagaaCGAGAAAATAGAGAGAGGGAttcatatgaacatatac g" /listShort="yxkA, galE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3608873..3608876 /Source="Nicolas_upshift_promotors" /id="U3068" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.854145854145854" /psig="0.998001998001998" /xcortree=1872 /SigmaFactorBS="atatgttcatatgaatccctctctctattttctcgttctATA GgtatactaaacgaaTCGATGTATAATCAGTGATAaacaaatacgcatgtaaacgtaa c" /listShort="yxjO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(3608882..3608888) /Source="Nicolas_upshift_promotors" /id="U3067" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=98 /SigmaFactorBS="acgtttacatgcgtatttgtttatcactgattatacatcgat tCGTTTAGtatacctatagaaCGAGAAAATAGAGAGAGGGAttcatatgaacatatac g" /listShort="yxkA, galE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3608891..3608910 /Source="Nicolas_upshift_promotors" /id="U3068" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.854145854145854" /psig="0.998001998001998" /xcortree=1872 /SigmaFactorBS="atatgttcatatgaatccctctctctattttctcgttctATA GgtatactaaacgaaTCGATGTATAATCAGTGATAaacaaatacgcatgtaaacgtaa c" /listShort="yxjO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3608894 /Source="Nicolas_upshifts" /id="U3068" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.854145854145854" /psig="0.998001998001998" /xcortree=1872 /SigmaFactorBS="atatgttcatatgaatccctctctctattttctcgttctATA GgtatactaaacgaaTCGATGTATAATCAGTGATAaacaaatacgcatgtaaacgtaa c" /listShort="yxjO" /GFF_Attribute="listLong" /label="upshifts" CDS 3608973..3609848 /gene="yxjO" /locus_tag="BSU_38880" /old_locus_tag="BSU38880" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12169591; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (LysR family)" /protein_id="NP_391767.1" /db_xref="EnsemblGenomes-Gn:BSU38880" /db_xref="EnsemblGenomes-Tr:CAB15914" /db_xref="GOA:P55181" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11898" /db_xref="UniProtKB/Swiss-Prot:P55181" /translation="MDLKWLQTFIAAAESESFREAAEHLYLTQPAVSQHMRKLEDELD MRLFLHSGRRVVLTDEGRLFLPYAKEMIHVYQAGKQKVSQWKQGYSRSLTLAVHPYIA SYILPRFLPAYIQKHPHVELSTHVAGSDAIKQAVEHNEADIGLSRKDPNTNTLYYQHI CEGTLCLAAPFQESRPDAASVLTRYRLLTHDHPSYGDAFLDNIRSHYPYLQMMAVGQT DTAVHMMKAGMGASFLPTYIIKQEEAEKKLMAVSTPAHLELPASQTFMMWKRNSEDIQ HFHAMLHDFMQREQV*" /label="yxjO CDS" gene 3608973..3609848 /gene="yxjO" /locus_tag="BSU_38880" /old_locus_tag="BSU38880" /label="yxjO gene" S_feature complement(3609223..3609311) /Source="Nicolas_S_feature" /locus_tag="new_3991968_3992056_c" /HighExp="GM 60, MG-0.1, MG 10, GM 5, S8, T0.30H, BC, S6, GM 15, GM 150" /AntisenseName="yxjO" /AntisenseCor="0.14032494397598999" /AntisenseRegPval="-1.7" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.0669" /TUlongSig="NA" /TUlongPSig="NA" /label="S1494" downshifts complement(3609245) /Source="Nicolas_upshifts" /id="D2018" /incds=1 /nref=22 /ntot=45 /MaxReadThrough="0.10815" /MaxDrop="6.05884" /score="5.06408541" /energy="-5.6" /TU="NA" /idTUdmin="U3069" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_no_box complement(3609271..3609371) /Source="Nicolas_upshift_promotors" /id="U3069" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.507492507492508" /psig="0.066933066933067" /xcortree=1478 /SigmaFactorBS="tttaatagcgtcagatccagccacatgagttgaaagctcgac atgcggatgtttttggatataggctggcagaaagcgaggcaagatataggacgcaatg t" /listShort="S1494" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(3609311) /Source="Nicolas_upshifts" /id="U3069" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.507492507492508" /psig="0.066933066933067" /xcortree=1478 /SigmaFactorBS="tttaatagcgtcagatccagccacatgagttgaaagctcgac atgcggatgtttttggatataggctggcagaaagcgaggcaagatataggacgcaatg t" /listShort="S1494" /GFF_Attribute="listLong" /label="upshifts" CDS 3609926..3610399 /gene="yxjN" /locus_tag="BSU_38890" /old_locus_tag="BSU38890" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein of unknown function" /protein_id="NP_391768.1" /db_xref="EnsemblGenomes-Gn:BSU38890" /db_xref="EnsemblGenomes-Tr:CAB15915" /db_xref="GOA:P55182" /db_xref="InterPro:IPR009916" /db_xref="InterPro:IPR020223" /db_xref="SubtiList:BG11897" /db_xref="UniProtKB/Swiss-Prot:P55182" /translation="MAMSPYIFIVLILIILSMYRERTVKPGKLLIIPLLLLWGVSASF QPAYFHSVLHVAISGILLLIGLACGFGIGKMVNVRIHPETGKVTSRGSLGSVILILVI LSLRMAARTWLPESNEMFIAIIHSMFFVPLGTITARNIMLYKAYRRLTAGKVSIQ*" /label="yxjN CDS" gene 3609926..3610399 /gene="yxjN" /locus_tag="BSU_38890" /old_locus_tag="BSU38890" /label="yxjN gene" CDS 3610417..3611637 /gene="yxjM" /locus_tag="BSU_38900" /old_locus_tag="BSU38900" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YxjL]" /protein_id="NP_391769.1" /db_xref="EnsemblGenomes-Gn:BSU38900" /db_xref="EnsemblGenomes-Tr:CAB15916" /db_xref="GOA:P55183" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11896" /db_xref="UniProtKB/Swiss-Prot:P55183" /translation="MNGQTPARHYYKKLVPSLILILNCIQFLSHPTKADPILLAFVFA VYLAFIWIIPYVASTAVSLSIFIGLWLLTDFFWAVSGQEQGAAYFLIVFLMIYAAFRL PSRLSLIFTACLIGGNILLLSSQGGSLNTIISNISIMLGLYVLFSSMRFRREARREAE RNHAELAKMHVQLEHAHKELQKAHAELQEASVLSLRYAVLEERTRIARDIHDSIGHEL TSVIVQLQSLPYILKSSKEDSEKVIQNVLSVARECLQEVRSVVHQMGRSESMVGLTAL RGLIHQVEERSGLHVSLDTAGLSEESWPPNVSETIYRILQEALTNIIRHADASHAAAV ISNDKSHLYVTITDDGQFTGSLTYGFGLTGMKERAEKAGGSLTFSAVQPSGLKIELSL PLMTTNKEQKDEQR*" /label="yxjM CDS" gene 3610417..3611637 /gene="yxjM" /locus_tag="BSU_38900" /old_locus_tag="BSU38900" /label="yxjM gene" CDS 3611624..3612280 /gene="yxjL" /locus_tag="BSU_38910" /old_locus_tag="BSU38910" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YxjM]" /protein_id="NP_391770.1" /db_xref="EnsemblGenomes-Gn:BSU38910" /db_xref="EnsemblGenomes-Tr:CAB15917" /db_xref="GOA:P55184" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11895" /db_xref="UniProtKB/Swiss-Prot:P55184" /translation="MNKDKIRVALADDQPLVREGFRYVINAQTDMTVSGEAGDGHDII ALAKQTKPDVILMDVQMPRCSGIEAAKDIMSALPNTKIVILTTFDTEEYVFEGIRAGA VGYLLKDTLPEELIDAIRAAARGEAIFRTVTAAKIISETFRAKQQTHAEELAEPFTKR ELEVLQQMAYGLRNEDIAEKLFVSESTVKTHVHRILQKCNAQDRTQAVVFAIRNGIVQ *" /label="yxjL CDS" gene 3611624..3612280 /gene="yxjL" /locus_tag="BSU_38910" /old_locus_tag="BSU38910" /label="yxjL gene" promotor_-35 3612278..3612283 /Source="Nicolas_upshift_promotors" /id="U3070" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.863136863136863" /psig="0.998001998001998" /xcortree=2234 /SigmaFactorBS="aggcagtcgtttttgccattcgaaacggtattgtgcaaTAGA AAtctctcatcccgcCATGCTAAAATAAGACAAAGgagatgattggaaatgaaagaag a" /listShort="pepT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3612297..3612316 /Source="Nicolas_upshift_promotors" /id="U3070" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.863136863136863" /psig="0.998001998001998" /xcortree=2234 /SigmaFactorBS="aggcagtcgtttttgccattcgaaacggtattgtgcaaTAGA AAtctctcatcccgcCATGCTAAAATAAGACAAAGgagatgattggaaatgaaagaag a" /listShort="pepT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3612300 /Source="Nicolas_upshifts" /id="U3070" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.863136863136863" /psig="0.998001998001998" /xcortree=2234 /SigmaFactorBS="aggcagtcgtttttgccattcgaaacggtattgtgcaaTAGA AAtctctcatcccgcCATGCTAAAATAAGACAAAGgagatgattggaaatgaaagaag a" /listShort="pepT" /GFF_Attribute="listLong" /label="upshifts" CDS 3612330..3613562 /gene="pepT" /locus_tag="BSU_38920" /old_locus_tag="BSU38920" /EC_number="3.4.11.4" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8978088, 10987140" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8978088, 10987140; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptidase T (tripeptidase)" /protein_id="NP_391771.1" /db_xref="EnsemblGenomes-Gn:BSU38920" /db_xref="EnsemblGenomes-Tr:CAB15918" /db_xref="GOA:P55179" /db_xref="InterPro:IPR001261" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR010161" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG11842" /db_xref="UniProtKB/Swiss-Prot:P55179" /translation="MKEEIIERFTTYVKVDTQSDESVDTCPSTPGQLTLGNMLVDELK SIGMQDAAIDENGYVMATLPSNTEKDVPTIGFLAHVDTATDFTGKNVNPQIIESYDGK DIVLNEQLQVTLSPDQFPELSGYKGHTLITTDGTTLLGADNKAGIAEIMTAMDYLIKH PEIKHGTIRVAFTPDEEIGRGPHKFDVKRFNASFAYTVDGGPLGELEYESFNAAAAKI TIKGNNVHPGTAKGKMINSAKIAMKLNSLLPADEAPEYTEGYEGFYHLLSIQGDVEET KLHYIIRDFDKENFQNRKETMKRAVEELQNEYGQDRILLDMNDQYYNMREKIEPVIEI VNIAKQAMENLGIEPKISPIRGGTDGSQLSYMGLPTPNIFTGGENFHGKFEYISVDNM VKAVNVIVEIAKQFEAQA*" /label="pepT CDS" gene 3612330..3613562 /gene="pepT" /locus_tag="BSU_38920" /old_locus_tag="BSU38920" /label="pepT gene" downshifts complement(3612347) /Source="Nicolas_upshifts" /id="D2019" /incds=0 /nref=4 /ntot=116 /MaxReadThrough="0.86167" /MaxDrop="3.19485" /score="-2.15704435" /energy="-9.1" /TU="NA" /idTUdmin="U3069" /TUdmin="-3102" /isTUend="FALSE" /label="downshifts" downshifts 3613547 /Source="Nicolas_upshifts" /id="D2020" /incds=0 /nref=203 /ntot=244 /MaxReadThrough="3.3949" /MaxDrop="6.35116" /score="27.2051031" /energy="-13.5" /TU="U3070" /idTUdmin="U3070" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" promotor_-35 3613608..3613617 /Source="Nicolas_upshift_promotors" /id="U3071" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1693 /SigmaFactorBS="ccagtccaaaaaaggactggcttttttgtgtgaaaaTGAAAC ATTTtaaacacgtcctCCGTAAAACAAGTATCaacaaatgaggaggaaaaacaatgac a" /listShort="S1495, S1496, S1497" /listLong="yxjJ, yxjI, NA, yxjH, NA, S1499, yxjG" /label="promotor_-35" promotor_-10 3613630..3613645 /Source="Nicolas_upshift_promotors" /id="U3071" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1693 /SigmaFactorBS="ccagtccaaaaaaggactggcttttttgtgtgaaaaTGAAAC ATTTtaaacacgtcctCCGTAAAACAAGTATCaacaaatgaggaggaaaaacaatgac a" /listShort="S1495, S1496, S1497" /listLong="yxjJ, yxjI, NA, yxjH, NA, S1499, yxjG" /label="promotor_-10" S_feature 3613632..3613854 /Source="Nicolas_S_feature" /locus_tag="new_3996377_3996599" /HighExp="T-0.40H, T0.30H, T0.0H, T-1.40H, T1.0H, T-1.10H, T3.30H, T2.0H, T1.30H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.80396299999999998" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1495" upshifts 3613632 /Source="Nicolas_upshifts" /id="U3071" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1693 /SigmaFactorBS="ccagtccaaaaaaggactggcttttttgtgtgaaaaTGAAAC ATTTtaaacacgtcctCCGTAAAACAAGTATCaacaaatgaggaggaaaaacaatgac a" /listShort="S1495, S1496, S1497" /listLong="yxjJ, yxjI, NA, yxjH, NA, S1499, yxjG" /label="upshifts" downshifts 3613811 /Source="Nicolas_upshifts" /id="D2021" /incds=0 /nref=162 /ntot=247 /MaxReadThrough="4.83682" /MaxDrop="4.66302" /score="-1.57383757" /energy="-6.2" /TU="U3071" /idTUdmin="U3070" /TUdmin=242 /isTUend="FALSE" /label="downshifts" promotor_-35 3613865..3613871 /Source="Nicolas_upshift_promotors" /id="U3072" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=236 /SigmaFactorBS="attcacccgtaccgcccaaatgctccgtaatttgggtttttT GTGTTCaattccgcaaaataGGGTATAAACCAAACAAGCaagaaaacagcacccaaaa a" /listShort="S1496, S1497, yxjJ, yxjI, NA" /listLong="yxjH, NA, S1499, yxjG" /label="promotor_-35" S_feature 3613884..3613984 /Source="Nicolas_S_feature" /locus_tag="new_3996629_3996729" /HighExp="Etha, Gly, Sw, Salt, B60, T0.30H, LoTm, M9-stat, T1.0H, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigWXY" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1496" upshifts 3613884 /Source="Nicolas_upshifts" /id="U3072" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=236 /SigmaFactorBS="attcacccgtaccgcccaaatgctccgtaatttgggtttttT GTGTTCaattccgcaaaataGGGTATAAACCAAACAAGCaagaaaacagcacccaaaa a" /listShort="S1496, S1497, yxjJ, yxjI, NA" /listLong="yxjH, NA, S1499, yxjG" /label="upshifts" promotor_-10 3613886..3613904 /Source="Nicolas_upshift_promotors" /id="U3072" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=236 /SigmaFactorBS="attcacccgtaccgcccaaatgctccgtaatttgggtttttT GTGTTCaattccgcaaaataGGGTATAAACCAAACAAGCaagaaaacagcacccaaaa a" /listShort="S1496, S1497, yxjJ, yxjI, NA" /listLong="yxjH, NA, S1499, yxjG" /label="promotor_-10" promotor_-35 3613963..3613970 /Source="Nicolas_upshift_promotors" /id="U3073" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2830 /SigmaFactorBS="aggtaattcgaattacgtaaacttaggttaaaagttaTATAA AGGaatttattttatcGTCGATAGTAACTATAGAAccaatcatcaacaagagcaaaca g" /listShort="S1497, yxjJ" /listLong="yxjI, NA, yxjH, NA, S1499, yxjG" /label="promotor_-35" promotor_-10 3613984..3614002 /Source="Nicolas_upshift_promotors" /id="U3073" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2830 /SigmaFactorBS="aggtaattcgaattacgtaaacttaggttaaaagttaTATAA AGGaatttattttatcGTCGATAGTAACTATAGAAccaatcatcaacaagagcaaaca g" /listShort="S1497, yxjJ" /listLong="yxjI, NA, yxjH, NA, S1499, yxjG" /label="promotor_-10" S_feature 3613986..3614083 /Source="Nicolas_S_feature" /locus_tag="new_3996731_3996828" /HighExp="Etha, T0.30H, Gly, T1.0H, Sw, Salt, T1.30H, GM 15, B60, GM-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigB, SigWXY" /TUshortPSig="1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1497" upshifts 3613986 /Source="Nicolas_upshifts" /id="U3073" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2830 /SigmaFactorBS="aggtaattcgaattacgtaaacttaggttaaaagttaTATAA AGGaatttattttatcGTCGATAGTAACTATAGAAccaatcatcaacaagagcaaaca g" /listShort="S1497, yxjJ" /listLong="yxjI, NA, yxjH, NA, S1499, yxjG" /label="upshifts" CDS 3614084..3614347 /gene="yxjJ" /locus_tag="BSU_38930" /old_locus_tag="BSU38930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391772.1" /db_xref="EnsemblGenomes-Gn:BSU38930" /db_xref="EnsemblGenomes-Tr:CAB15919" /db_xref="GOA:P94353" /db_xref="SubtiList:BG12540" /db_xref="UniProtKB/Swiss-Prot:P94353" /translation="MLFIDLEFFEYFLAFYPYNREYQNFFWEVCNMILFIIIALCGYL LFSFSKDNRRKPQKTSPLPAAAPHHNNLIDLDAIRQKRRMHLS*" /label="yxjJ CDS" gene 3614084..3614347 /gene="yxjJ" /locus_tag="BSU_38930" /old_locus_tag="BSU38930" /label="yxjJ gene" promotor_-35 3614111..3614114 /Source="Nicolas_upshift_promotors" /id="U3074" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.541458541458541" /psig="0.554445554445554" /xcortree=653 /SigmaFactorBS="ttcttgttatttattgatttagaattttttGAATactttttg gcatttTATCCGTACAATAGAGAGTAccaaaactttttttgggaggtatgtaatatga t" /GFF_Attribute="listShort" /listLong="yxjI, NA, yxjH, NA, S1499, yxjG" /label="promotor_-35" promotor_-10 3614129..3614148 /Source="Nicolas_upshift_promotors" /id="U3074" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.541458541458541" /psig="0.554445554445554" /xcortree=653 /SigmaFactorBS="ttcttgttatttattgatttagaattttttGAATactttttg gcatttTATCCGTACAATAGAGAGTAccaaaactttttttgggaggtatgtaatatga t" /GFF_Attribute="listShort" /listLong="yxjI, NA, yxjH, NA, S1499, yxjG" /label="promotor_-10" upshifts 3614141 /Source="Nicolas_upshifts" /id="U3074" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.541458541458541" /psig="0.554445554445554" /xcortree=653 /SigmaFactorBS="ttcttgttatttattgatttagaattttttGAATactttttg gcatttTATCCGTACAATAGAGAGTAccaaaactttttttgggaggtatgtaatatga t" /GFF_Attribute="listShort" /listLong="yxjI, NA, yxjH, NA, S1499, yxjG" /label="upshifts" downshifts 3614295 /Source="Nicolas_upshifts" /id="D2022" /incds=0 /nref=4 /ntot=92 /MaxReadThrough="7.33654" /MaxDrop="3.1638" /score="-1.57383757" /energy="-6.2" /TU="U3072,U3073,U3074" /idTUdmin="U3073" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" downshifts 3614339 /Source="Nicolas_upshifts" /id="D2023" /incds=0 /nref=44 /ntot=188 /MaxReadThrough="5.58502" /MaxDrop="4.5161" /score="-1.57383757" /energy="-6.2" /TU="U3072,U3073,U3074" /idTUdmin="U3073" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" promotor_-35 3614414..3614423 /Source="Nicolas_upshift_promotors" /id="U3075" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1670 /SigmaFactorBS="gctgctgaatcacgcagccttttaaaattgttttgatttaga gccTGAAACCTTTtcgccacctatCCGTAATTTCATACAAggcaaacccaaaggagac t" /listShort="yxjI, NA, yxjH, NA, S1499, yxjG" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3614429 /Source="Nicolas_upshifts" /id="U3075" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1670 /SigmaFactorBS="gctgctgaatcacgcagccttttaaaattgttttgatttaga gccTGAAACCTTTtcgccacctatCCGTAATTTCATACAAggcaaacccaaaggagac t" /listShort="yxjI, NA, yxjH, NA, S1499, yxjG" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3614435..3614450 /Source="Nicolas_upshift_promotors" /id="U3075" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1670 /SigmaFactorBS="gctgctgaatcacgcagccttttaaaattgttttgatttaga gccTGAAACCTTTtcgccacctatCCGTAATTTCATACAAggcaaacccaaaggagac t" /listShort="yxjI, NA, yxjH, NA, S1499, yxjG" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3614476..3614964 /gene="yxjI" /locus_tag="BSU_38940" /old_locus_tag="BSU38940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391773.1" /db_xref="EnsemblGenomes-Gn:BSU38940" /db_xref="EnsemblGenomes-Tr:CAB15920" /db_xref="InterPro:IPR007612" /db_xref="InterPro:IPR025659" /db_xref="SubtiList:BG12539" /db_xref="UniProtKB/Swiss-Prot:P94352" /translation="MIELFMKQKMFSFKDAFHIYDRDEQETFKVEGRFFSLGDSLQMT DSSGKTLVSIEQKLMSLLPRYEISIGGKTVCEVTKKVTFSKPKFVISGLNWEIDGDLW RDEFQLTDGENVRMSVSKKWLSWGDSYHLQIAYEEDVLICTAIAIVLDMVLYNDEDES IF*" /label="yxjI CDS" gene 3614476..3614964 /gene="yxjI" /locus_tag="BSU_38940" /old_locus_tag="BSU38940" /label="yxjI gene" promotor_-35 3614969..3614976 /Source="Nicolas_upshift_promotors" /id="U3076" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=2891 /SigmaFactorBS="cgatgaagatgaaagtattttctaaaaagCATTGACAattga tccaaaagTAATAATATTAAGATAATTGaaatctgaatatgaagttgtaccttatcaa g" /listShort="NA, yxjH, NA, S1499, yxjG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3614990..3615009 /Source="Nicolas_upshift_promotors" /id="U3076" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=2891 /SigmaFactorBS="cgatgaagatgaaagtattttctaaaaagCATTGACAattga tccaaaagTAATAATATTAAGATAATTGaaatctgaatatgaagttgtaccttatcaa g" /listShort="NA, yxjH, NA, S1499, yxjG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3615000 /Source="Nicolas_upshifts" /id="U3076" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=2891 /SigmaFactorBS="cgatgaagatgaaagtattttctaaaaagCATTGACAattga tccaaaagTAATAATATTAAGATAATTGaaatctgaatatgaagttgtaccttatcaa g" /listShort="NA, yxjH, NA, S1499, yxjG" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 3615030..3615136 /gene="mswI" /locus_tag="BSU_misc_RNA_61" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /function="16.3: Control" /label="mswI RNA" gene 3615030..3615136 /gene="mswI" /locus_tag="BSU_misc_RNA_61" /label="mswI gene" downshifts 3615131 /Source="Nicolas_upshifts" /id="D2024" /incds=0 /nref=22 /ntot=102 /MaxReadThrough="7.18775" /MaxDrop="3.7896" /score="9.64734237" /energy="-14.5" /TU="U3075,U3076" /idTUdmin="U3072" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 3615219..3616352 /gene="yxjH" /locus_tag="BSU_38950" /old_locus_tag="BSU38950" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12456320, 14563871, 17098890, 17114254; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative methyl-tetrahydrofolate methyltransferase (biofilm formation)" /protein_id="NP_391774.2" /db_xref="EnsemblGenomes-Gn:BSU38950" /db_xref="EnsemblGenomes-Tr:CAB15921" /db_xref="GOA:P42319" /db_xref="InterPro:IPR002629" /db_xref="SubtiList:BG11157" /db_xref="UniProtKB/Swiss-Prot:P42319" /translation="MAQQTNVAGQKTEKQRKAPFRADHVGSLLRSVPVKEARQKKAAG EMTAEQLRDIENQEITRIVEKQKEIGLDVVTDGEFRRSWWHYDFLEGLDGVEPFIPAE GIQFHNTKTKARSIKVTGKLDFTSHPALGDYQFLHEIAGNATPKLTIPSPNMLFFGEK ADKGIYDDQEEYFHDMAQAYKKAIKAFYDAGCRYLQLDDTSWSLFFEDKGREVVRALG GDPETLPAIFAKTINDAVADRPDDLTITMHICRGNFRSTWAASGGYDAVAETILDGLN LDGLFLEYDDDRSGNFDPLRFVKRKDLQIVLGLITSKYGELENPEDVKRRINEAARFV SLDQLCLSPQCGFASTEEGNLLTEEQQWAKLRHVIDIANDVWR*" /label="yxjH CDS" gene 3615219..3616352 /gene="yxjH" /locus_tag="BSU_38950" /old_locus_tag="BSU38950" /label="yxjH gene" S_feature complement(3615492..3615735) /Source="Nicolas_S_feature" /locus_tag="new_3998237_3998480_c" /HighExp="dia15, Diami, H2O2, dia5, C90, Paraq, Sw, BC, LBGstat, Lbtran" /AntisenseName="yxjH" /AntisenseCor="-0.34694665046491102" /AntisenseRegPval="-8.3000000000000007" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1498" promotor_-10 complement(3615730..3615749) /Source="Nicolas_upshift_promotors" /id="U3077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.982017982017982" /psig="0.997002997002997" /xcortree=2079 /SigmaFactorBS="taacggcagccagcatcatagaaggcttTGATTGCTtttttg tacgcttgGGCCATATCATGAAAGTATTcctcttgatcgtcataaatccctttatccg c" /listShort="S1498" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3615739) /Source="Nicolas_upshifts" /id="U3077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.982017982017982" /psig="0.997002997002997" /xcortree=2079 /SigmaFactorBS="taacggcagccagcatcatagaaggcttTGATTGCTtttttg tacgcttgGGCCATATCATGAAAGTATTcctcttgatcgtcataaatccctttatccg c" /listShort="S1498" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3615764..3615771) /Source="Nicolas_upshift_promotors" /id="U3077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.982017982017982" /psig="0.997002997002997" /xcortree=2079 /SigmaFactorBS="taacggcagccagcatcatagaaggcttTGATTGCTtttttg tacgcttgGGCCATATCATGAAAGTATTcctcttgatcgtcataaatccctttatccg c" /listShort="S1498" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3616358..3616365 /Source="Nicolas_upshift_promotors" /id="U3078" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.97002997002997" /psig=1 /xcortree=2892 /SigmaFactorBS="gacattgccaacgatgtgtggagataatctatCATTGACAga aatagaaaatgtGTGAATAATAGATACTATCAgaaaatttaataaaaaggttttcctt a" /listShort="NA, S1499, yxjG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3616380..3616399 /Source="Nicolas_upshift_promotors" /id="U3078" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.97002997002997" /psig=1 /xcortree=2892 /SigmaFactorBS="gacattgccaacgatgtgtggagataatctatCATTGACAga aatagaaaatgtGTGAATAATAGATACTATCAgaaaatttaataaaaaggttttcctt a" /listShort="NA, S1499, yxjG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3616386 /Source="Nicolas_upshifts" /id="U3078" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.97002997002997" /psig=1 /xcortree=2892 /SigmaFactorBS="gacattgccaacgatgtgtggagataatctatCATTGACAga aatagaaaatgtGTGAATAATAGATACTATCAgaaaatttaataaaaaggttttcctt a" /listShort="NA, S1499, yxjG" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 3616421..3616527 /gene="mswJ" /locus_tag="BSU_misc_RNA_62" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /function="16.3: Control" /label="mswJ RNA" gene 3616421..3616527 /gene="mswJ" /locus_tag="BSU_misc_RNA_62" /label="mswJ gene" downshifts 3616474 /Source="Nicolas_upshifts" /id="D2025" /incds=0 /nref=3 /ntot=21 /MaxReadThrough="8.35488" /MaxDrop="3.50346" /score="29.0146782" /energy="-14.5" /TU="U3075,U3076,U3078" /idTUdmin="U3075" /TUdmin="-1254" /isTUend="FALSE" /label="downshifts" S_feature 3616528..3616604 /Source="Nicolas_S_feature" /locus_tag="new_3999273_3999349" /HighExp="MG 5, MG t5, T1.0H, MG 10, T1.30H, BMM, T0.30H, T-0.40H, T0.0H, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigWXY" /TUshortPSig="1, 1, 1" /TUlongSig="SigA, SigD, SigB, SigWXY" /TUlongPSig="0.554, 1, 1, 1" /label="S1499" CDS 3616605..3617741 /gene="yxjG" /locus_tag="BSU_38960" /old_locus_tag="BSU38960" /function="16.11: Scavenge (Catabolism)" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12456320, 14563871, 17098890, 17114254, 21749987; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative methyltetrahydrofolate methyltransferase (biofilm formation)" /protein_id="NP_391775.3" /db_xref="EnsemblGenomes-Gn:BSU38960" /db_xref="EnsemblGenomes-Tr:CAB15922" /db_xref="GOA:P42318" /db_xref="InterPro:IPR002629" /db_xref="SubtiList:BG11156" /db_xref="UniProtKB/Swiss-Prot:P42318" /translation="MSQQTTPAEQKSLQRKKPPFRADQVGSLLRSEPVKKARLQKAAG EMTAEQLRQIENDEIIRIVEKQKETGLNVVTDGEFRRAWWHFDFLENLDGVEPFTPEQ GIQFHNVQTKARGIKVTGDIDFSTHPMLEDYSFLHSIAGDATPKMTIPSPNMLFFRGK LEKDEYKNDYQLFQHDVSKAYKKAIQAFYDRGCRYLQLDDTAWAVFLSEKGLKQIEAF GTTPDELRQLFAKSINDAIADRPDDLTVTMHICRGNFQSTWTAEGGYDAAAETIFDGL NLDGLFLEYDDSRSGGFEPLRYVKRSDLQLVLGLVTSKFGELENPDDVKRRIEEASRY VSLDQLCLSPQCGFASTEEGNKLTEEQQWAKLRHVVEIANDVWK*" /label="yxjG CDS" gene 3616605..3617741 /gene="yxjG" /locus_tag="BSU_38960" /old_locus_tag="BSU38960" /label="yxjG gene" downshifts 3617728 /Source="Nicolas_upshifts" /id="D2026" /incds=0 /nref=81 /ntot=187 /MaxReadThrough="4.24668" /MaxDrop="5.8124" /score="11.1243305" /energy="-12.8" /TU="U3076,U3078" /idTUdmin="U3075" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3617794..3618567) /gene="yxjF" /locus_tag="BSU_38970" /old_locus_tag="BSU38970" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydroxyacid dehydrogenase" /protein_id="NP_391776.2" /db_xref="EnsemblGenomes-Gn:BSU38970" /db_xref="EnsemblGenomes-Tr:CAB15923" /db_xref="GOA:P42317" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR011294" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11155" /db_xref="UniProtKB/Swiss-Prot:P42317" /translation="MRKQVALVTGAAGGIGFEIAREFAREGASVIVSDLRPEACEKAA SKLAEEGFDAAAIPYDVTKEAQVADTVNVIQKQYGRLDILVNNAGIQHVAPIEEFPTD TFEQLIKVMLTAPFIAMKHVFPIMKKQQFGRIINIASVNGLVGFAGKSAYNSAKHGVI GLTKVGALEGAPHGITVNALCPGYVDTQLVRNQLSDLSKTRNVPYDSVLEQVIFPLVP QKRLLSVKEIADYAVFLASEKAKGVTGQAVVLDGGYTAQ*" /label="yxjF CDS" gene complement(3617794..3618567) /gene="yxjF" /locus_tag="BSU_38970" /old_locus_tag="BSU38970" /label="yxjF gene" downshifts complement(3617804) /Source="Nicolas_upshifts" /id="D2027" /incds=0 /nref=23 /ntot=63 /MaxReadThrough="0.65" /MaxDrop="6.97604" /score="24.6585594" /energy="-12.8" /TU="NA" /idTUdmin="U3079" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3618584..3619234) /gene="scoB" /locus_tag="BSU_38980" /old_locus_tag="BSU38980" /EC_number="2.8.3.5" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17363272, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetoacetyl CoA-transferase (subunit B)" /protein_id="NP_391777.1" /db_xref="EnsemblGenomes-Gn:BSU38980" /db_xref="EnsemblGenomes-Tr:CAB15924" /db_xref="GOA:P42316" /db_xref="InterPro:IPR004164" /db_xref="InterPro:IPR004165" /db_xref="InterPro:IPR012791" /db_xref="PDB:3CDK" /db_xref="SubtiList:BG11154" /db_xref="UniProtKB/Swiss-Prot:P42316" /translation="MKEARKRMVKRAVQEIKDGMNVNLGIGMPTLVANEIPDGVHVML QSENGLLGIGPYPLEGTEDADLINAGKETITEVTGASYFDSAESFAMIRGGHIDLAIL GGMEVSEQGDLANWMIPGKMVKGMGGAMDLVNGAKRIVVIMEHVNKHGESKVKKTCSL PLTGQKVVHRLITDLAVFDFVNGRMTLTELQDGVTIEEVYEKTEADFAVSQSVLNS*" /label="scoB CDS" gene complement(3618584..3619234) /gene="scoB" /locus_tag="BSU_38980" /old_locus_tag="BSU38980" /label="scoB gene" CDS complement(3619231..3619947) /gene="scoA" /locus_tag="BSU_38990" /old_locus_tag="BSU38990" /EC_number="2.8.3.5" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17363272; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="acetoacetyl CoA-transferase (subunit A)" /protein_id="NP_391778.1" /db_xref="EnsemblGenomes-Gn:BSU38990" /db_xref="EnsemblGenomes-Tr:CAB15925" /db_xref="GOA:P42315" /db_xref="InterPro:IPR004163" /db_xref="InterPro:IPR004165" /db_xref="InterPro:IPR012792" /db_xref="PDB:3CDK" /db_xref="SubtiList:BG11153" /db_xref="UniProtKB/Swiss-Prot:P42315" /translation="MGKVLSSSKEAAKLIHDGDTLIAGGFGLCGIPEQLILSIRDQGV KDLTVVSNNCGVDDWGLGLLLANKQIKKMIASYVGENKIFERQFLSGELEVELVPQGT LAERIRAGGAGIPGFYTATGVGTSIAEGKEHKTFGGRTYVLERGITGDVAIVKAWKAD TMGNLIFRKTARNFNPIAAMAGKITIAEAEEIVEAGELDPDHIHTPGIYVQHVVLGAS QEKRIEKRTVQQASGKGEAK*" /label="scoA CDS" gene complement(3619231..3619947) /gene="scoA" /locus_tag="BSU_38990" /old_locus_tag="BSU38990" /label="scoA gene" CDS complement(3619971..3621389) /gene="yxjC" /locus_tag="BSU_39000" /old_locus_tag="BSU39000" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative acid metabolite permease" /protein_id="NP_391779.3" /db_xref="EnsemblGenomes-Gn:BSU39000" /db_xref="EnsemblGenomes-Tr:CAB15926" /db_xref="GOA:P42314" /db_xref="SubtiList:BG11152" /db_xref="UniProtKB/Swiss-Prot:P42314" /translation="MELIIILLALGLLMFTAYRGFSVILFAPICALFAVLLTDPSHVL PFFSSIFMEKMAGFIKLYFPVFLLGAIFGKVVEMAGLAASIAKTIVRLVGAKRAILAI VLMGAVLTYSGVSLFVVVFAVYPFAKNMFQEANIPKRLIPGTIALGAFTFTMDALPGT PQIQNVIPTSFFKTDIYAAPWLGLMGAVIVLAAGMLYLESRRKKAQASGEGYGGFDSQ NAPAPESIESAAEPDKSPIRHALAFVPLILVGAVNKYFTIYLPKWYPNGFDFSSIGLK EFGRLDISSAAAIWSVEIALVIGIITTILFDWRSVFAQLKEGLNEGIGGALLASMNTG AEYGFGGIIAALPGFHKLSSGISHTFTDPLVNGAVTTTALAGITGSASGGMGIALSAM SEQYLQAIQAYNIPPEVMHRVISMASGGMDTLPHNGAVITLLAVTGLTHRQSYRDIFA ITLIKTAAVFAVIAIYSLTGLV*" /label="yxjC CDS" gene complement(3619971..3621389) /gene="yxjC" /locus_tag="BSU_39000" /old_locus_tag="BSU39000" /label="yxjC gene" promotor_-10 complement(3620557..3620575) /Source="Nicolas_upshift_promotors" /id="U3079" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=762 /SigmaFactorBS="gtgaataaatatttcaccatttacctgccaaagtggtatcCG AATGgatttgatttttcttCCATAGGATTAAAGGAGTTcggcaggcttgatatttctt c" /listShort="scoA, scoB, yxjF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3620576) /Source="Nicolas_upshifts" /id="U3079" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=762 /SigmaFactorBS="gtgaataaatatttcaccatttacctgccaaagtggtatcCG AATGgatttgatttttcttCCATAGGATTAAAGGAGTTcggcaggcttgatatttctt c" /listShort="scoA, scoB, yxjF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3620591..3620596) /Source="Nicolas_upshift_promotors" /id="U3079" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=762 /SigmaFactorBS="gtgaataaatatttcaccatttacctgccaaagtggtatcCG AATGgatttgatttttcttCCATAGGATTAAAGGAGTTcggcaggcttgatatttctt c" /listShort="scoA, scoB, yxjF" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3621390..3621474) /Source="Nicolas_S_feature" /locus_tag="new_4004135_4004219_c" /HighExp="S5, S4, S6, S3, S7, M9-stat, B60, S8, T4.0H, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1500" promotor_-10 complement(3621458..3621476) /Source="Nicolas_upshift_promotors" /id="U3080" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1046 /SigmaFactorBS="ggaaagctccgaaaaaaggagctttccttttttaatcGGAAT AgttggcccacgcttcTCGTACATATGGAAAGGGGacggaaacagccgatgcggacag g" /listShort="S1500, yxjC, scoA, scoB, yxjF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3621474) /Source="Nicolas_upshifts" /id="U3080" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1046 /SigmaFactorBS="ggaaagctccgaaaaaaggagctttccttttttaatcGGAAT AgttggcccacgcttcTCGTACATATGGAAAGGGGacggaaacagccgatgcggacag g" /listShort="S1500, yxjC, scoA, scoB, yxjF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3621492..3621497) /Source="Nicolas_upshift_promotors" /id="U3080" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1046 /SigmaFactorBS="ggaaagctccgaaaaaaggagctttccttttttaatcGGAAT AgttggcccacgcttcTCGTACATATGGAAAGGGGacggaaacagccgatgcggacag g" /listShort="S1500, yxjC, scoA, scoB, yxjF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3621543..3622391) /gene="rlmA" /locus_tag="BSU_39010" /old_locus_tag="BSU39010" /EC_number="2.1.1.188" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 11967079, 14999102, 18406425, 23716046; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="23S rRNA m(1)G748 methyltransferase (class II)" /protein_id="NP_391780.1" /db_xref="EnsemblGenomes-Gn:BSU39010" /db_xref="EnsemblGenomes-Tr:CAB15927" /db_xref="GOA:P42313" /db_xref="InterPro:IPR013216" /db_xref="InterPro:IPR016718" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11151" /db_xref="UniProtKB/Swiss-Prot:P42313" /translation="MKRTVDFSMFRCPLCDSSMDAASGKSLICTERGHTFDLSRHGYV NFLTKPVKTSYGAELFEARSRLIGECGFFDPLHDAIAELISHPKSGHEAFTILDSGCG EGSHLNALCGFDYAGKAAIGTGIDLSKDGILKASKAFKDLMWAVADVARAPFHDRQFD VVLSIFSPSNYAEFHRLLKNDGMLIKVVPRSDYLIELRQFLYTDSPRRTYSNTAAVER FTANAAHSRPVRLRYVKTLDQQAIHWLLKMTPLAWSAPKDRVSLLKEMKSADITVDVD ILIGMK*" /label="rlmA CDS" gene complement(3621543..3622391) /gene="rlmA" /locus_tag="BSU_39010" /old_locus_tag="BSU39010" /label="rlmA gene" downshifts complement(3621553) /Source="Nicolas_upshifts" /id="D2028" /incds=0 /nref=54 /ntot=218 /MaxReadThrough="1.618" /MaxDrop="4.63737" /score="17.0758624" /energy="-15.1" /TU="NA" /idTUdmin="U3081" /TUdmin="-9" /isTUend="TRUE" /label="downshifts" S_feature complement(3622392..3622577) /Source="Nicolas_S_feature" /locus_tag="new_4005137_4005322_c" /HighExp="B60, LBGstat, LPhT, M9-stat, C30, T0.30H, HPh, Oxctl, Heat, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1501" promotor_-10 complement(3622566..3622585) /Source="Nicolas_upshift_promotors" /id="U3081" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=2742 /SigmaFactorBS="agcatgtcagtactgatttttcttcactataaGGTTCcagct cctggatattTGTTGTATGATGGAAACGGGgaaacccatacagcagaaagggagtttt t" /listShort="S1501, yxjB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3622577) /Source="Nicolas_upshifts" /id="U3081" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=2742 /SigmaFactorBS="agcatgtcagtactgatttttcttcactataaGGTTCcagct cctggatattTGTTGTATGATGGAAACGGGgaaacccatacagcagaaagggagtttt t" /listShort="S1501, yxjB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3622579..3623304) /Source="Nicolas_S_feature" /locus_tag="new_4005324_4006049_c" /HighExp="LBGstat, C30, GM 25, Heat, GM 10, GM 45, GM 60, GM 90, T0.30H, GM 120" /AntisenseName="NA" /AntisenseCor="0.20859849915331599" /AntisenseRegPval="-3.2" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1502" promotor_-35 complement(3622601..3622605) /Source="Nicolas_upshift_promotors" /id="U3081" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=2742 /SigmaFactorBS="agcatgtcagtactgatttttcttcactataaGGTTCcagct cctggatattTGTTGTATGATGGAAACGGGgaaacccatacagcagaaagggagtttt t" /listShort="S1501, yxjB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3622739..3622746 /Source="Nicolas_upshift_promotors" /id="U3082" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.478521478521479" /psig="0.996003996003996" /xcortree=2667 /SigmaFactorBS="taaattttattattgtgaaaatagttaaaaaGGTTGATTttc aaaaagtgaAAGGATAAAATACTGCTATCatcttagaaaaagacattcttgtatatga t" /listShort="NA, S1503, yxjA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3622759..3622778 /Source="Nicolas_upshift_promotors" /id="U3082" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.478521478521479" /psig="0.996003996003996" /xcortree=2667 /SigmaFactorBS="taaattttattattgtgaaaatagttaaaaaGGTTGATTttc aaaaagtgaAAGGATAAAATACTGCTATCatcttagaaaaagacattcttgtatatga t" /listShort="NA, S1503, yxjA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3622768 /Source="Nicolas_upshifts" /id="U3082" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.478521478521479" /psig="0.996003996003996" /xcortree=2667 /SigmaFactorBS="taaattttattattgtgaaaatagttaaaaaGGTTGATTttc aaaaagtgaAAGGATAAAATACTGCTATCatcttagaaaaagacattcttgtatatga t" /listShort="NA, S1503, yxjA" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 3622778..3622880 /gene="gswB" /locus_tag="BSU_misc_RNA_63" /product="guanine riboswitch" /experiment="publication(s) with functional evidences, PMID:12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477; Product type n: RNA" /label="gswB RNA" gene 3622778..3622880 /gene="gswB" /locus_tag="BSU_misc_RNA_63" /label="gswB gene" S_feature 3622881..3622984 /Source="Nicolas_S_feature" /locus_tag="new_4005626_4005729" /HighExp="C90, G180, M40t45, dia15, LBGexp, Lbexp, Lbtran, G135, Mt0, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1503" promotor_-35 3622956..3622962 /Source="Nicolas_upshift_promotors" /id="U3083" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=809 /SigmaFactorBS="tcacactttctgcacttccagaatttgtgaAGGATAAgagct ttttttgtTTCCATAATAACcctcataggagttgctatcatgtactttttactaaacc t" /listShort="yxjA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3622976..3622987 /Source="Nicolas_upshift_promotors" /id="U3083" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=809 /SigmaFactorBS="tcacactttctgcacttccagaatttgtgaAGGATAAgagct ttttttgtTTCCATAATAACcctcataggagttgctatcatgtactttttactaaacc t" /listShort="yxjA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3622986 /Source="Nicolas_upshifts" /id="U3083" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=809 /SigmaFactorBS="tcacactttctgcacttccagaatttgtgaAGGATAAgagct ttttttgtTTCCATAATAACcctcataggagttgctatcatgtactttttactaaacc t" /listShort="yxjA" /GFF_Attribute="listLong" /label="upshifts" CDS 3623007..3624200 /gene="nupG" /locus_tag="BSU_39020" /old_locus_tag="BSU39020" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12787499, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="purine nucleoside transporter" /protein_id="NP_391781.2" /db_xref="EnsemblGenomes-Gn:BSU39020" /db_xref="EnsemblGenomes-Tr:CAB15928" /db_xref="GOA:P42312" /db_xref="InterPro:IPR002668" /db_xref="InterPro:IPR008276" /db_xref="InterPro:IPR011657" /db_xref="InterPro:IPR018270" /db_xref="SubtiList:BG11150" /db_xref="UniProtKB/Swiss-Prot:P42312" /translation="MYFLLNLVGLIVIMAVVFLCSPQKKKIKWRPIITLIVLELLITW FMLGTKVGSWAIGKIGDFFTWLIACASDGIAFAFPSVMANETVDFFFSALLPIIFIVT FFDILTYFGILPWLIDKIGWVISKASRLPKLESFFSIQMMFLGNTEALAVIRQQLTVL SNNRLLTFGLMSMSSISGSIIGSYLSMVPATYVFTAIPLNCLNALIIANLLNPVHVPE DEDIIYTPPKEEKKDFFSTISNSMLVGMNMVIVILAMVIGYVALTSAVNGILGVFVHG LTIQTIFAYLFSPFAFLLGLPVHDAMYVAQLMGMKLATNEFVAMLDLKNNLKSLPPHT VAVATTFLTSFANFSTVGMIYGTYNSILDGEKSTVIGRNVWKLLVSGIAVSLLSAAIV GLFVW*" /label="nupG CDS" gene 3623007..3624200 /gene="nupG" /locus_tag="BSU_39020" /old_locus_tag="BSU39020" /label="nupG gene" promotor_-10 complement(3623291..3623309) /Source="Nicolas_upshift_promotors" /id="U3084" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2848 /SigmaFactorBS="cgattttatcaatcagccaaggcaaaatgccgaaatacGTTA AAATatcaaagaatgtGACGATAAAGATAATTGGAagaagcgcactaaagaaaaagtc t" /listShort="S1502, S1501, yxjB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3623307) /Source="Nicolas_upshifts" /id="U3084" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2848 /SigmaFactorBS="cgattttatcaatcagccaaggcaaaatgccgaaatacGTTA AAATatcaaagaatgtGACGATAAAGATAATTGGAagaagcgcactaaagaaaaagtc t" /listShort="S1502, S1501, yxjB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3623322..3623329) /Source="Nicolas_upshift_promotors" /id="U3084" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2848 /SigmaFactorBS="cgattttatcaatcagccaaggcaaaatgccgaaatacGTTA AAATatcaaagaatgtGACGATAAAGATAATTGGAagaagcgcactaaagaaaaagtc t" /listShort="S1502, S1501, yxjB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3623976 /Source="Nicolas_upshifts" /id="D2029" /incds=1 /nref=1 /ntot=58 /MaxReadThrough="5.88279" /MaxDrop="2.4159" /score="8.04757856" /energy="-16.6" /TU="U3082,U3083" /idTUdmin="U3082" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" downshifts 3624196 /Source="Nicolas_upshifts" /id="D2030" /incds=0 /nref=71 /ntot=204 /MaxReadThrough="2.7474" /MaxDrop="4.05925" /score="8.04757856" /energy="-16.6" /TU="NA" /idTUdmin="U3082" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3624242..3624670) /gene="yxiTc" /locus_tag="BSU_39029" /old_locus_tag="BSU39029" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (C-terminus)" /translation="KTKKQANSRALKREYQTSFSVKYNAAGKLSIQTLNYIYSGGAHG LTSVQSFNYDLKAQKRVTLDQILNTKTKVSKTRDYLYSYIKKHDVLFFSDVKKEDITL NRDTMFYFTANGIAIVFGQYDLGPYAAGIRDVQVPASIYQ*" /label="yxiTc CDS" gene complement(3624242..3624670) /gene="yxiTc" /locus_tag="BSU_39029" /old_locus_tag="BSU39029" /pseudo /label="yxiTc gene" CDS complement(3624671..3624913) /gene="yxiTn" /locus_tag="BSU_39030" /old_locus_tag="BSU39030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (N-terminus)" /db_xref="PSEUDO:CAB15929.2" /db_xref="SubtiList:BG11149" /db_xref="UniProtKB/Swiss-Prot:P42311" /translation="MKWNNMLKAAGIAVLLFSVFAYAAPSLKAVQAKTPTVSTHTYKK IKELTYPQVHHVGNAAFEKKINQELKAYMNNRIRNT*" /label="yxiTn CDS" gene complement(3624671..3624913) /gene="yxiTn" /locus_tag="BSU_39030" /old_locus_tag="BSU39030" /pseudo /label="yxiTn gene" S_feature complement(3624914..3624977) /Source="Nicolas_S_feature" /locus_tag="new_4007659_4007722_c" /HighExp="T2.30H, S6, Etha, T3.30H, S5, BT, T3.0H, T4.0H, T2.0H, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.942" /TUlongSig="NA" /TUlongPSig="NA" /label="S1504" promotor_-10 complement(3624966..3624981) /Source="Nicolas_upshift_promotors" /id="U3085" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.942057942057942" /psig="0.942057942057942" /xcortree=757 /SigmaFactorBS="tctttttttattggaaaaatcatgctgttagacctAGAAACT TCTttcgatttaatCAGTCTATAAAAGTGTgtattgcttaaataagggaatgataaac a" /listShort="S1504, yxiT, yxiT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3624977) /Source="Nicolas_upshifts" /id="U3085" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.942057942057942" /psig="0.942057942057942" /xcortree=757 /SigmaFactorBS="tctttttttattggaaaaatcatgctgttagacctAGAAACT TCTttcgatttaatCAGTCTATAAAAGTGTgtattgcttaaataagggaatgataaac a" /listShort="S1504, yxiT, yxiT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3624993..3625002) /Source="Nicolas_upshift_promotors" /id="U3085" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.942057942057942" /psig="0.942057942057942" /xcortree=757 /SigmaFactorBS="tctttttttattggaaaaatcatgctgttagacctAGAAACT TCTttcgatttaatCAGTCTATAAAAGTGTgtattgcttaaataagggaatgataaac a" /listShort="S1504, yxiT, yxiT" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3625010 /Source="Nicolas_upshifts" /id="D2031" /incds=0 /nref=10 /ntot=69 /MaxReadThrough="0.814549999999999" /MaxDrop="3.89525" /score="14.5338714" /energy="-6.9" /TU="NA" /idTUdmin="U3082" /TUdmin=814 /isTUend="FALSE" /label="downshifts" CDS complement(3625058..3625348) /gene="yxiS" /locus_tag="BSU_39040" /old_locus_tag="BSU39040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391783.2" /db_xref="EnsemblGenomes-Gn:BSU39040" /db_xref="EnsemblGenomes-Tr:CAB15930" /db_xref="SubtiList:BG11148" /db_xref="UniProtKB/Swiss-Prot:P42310" /translation="MNEKQLTEAYERDENMMILVFAQWCVNHDLDPMELYAKAYPQQK LNESLKKTMDDLVVPKHEAEHIPDQTVIAVLEMFGNTDLAQALHEAISGRKQ*" /label="yxiS CDS" gene complement(3625058..3625348) /gene="yxiS" /locus_tag="BSU_39040" /old_locus_tag="BSU39040" /label="yxiS gene" downshifts complement(3625064) /Source="Nicolas_upshifts" /id="D2032" /incds=0 /nref=168 /ntot=241 /MaxReadThrough="3.10756" /MaxDrop="6.10709" /score="16.5130207" /energy="-6.9" /TU="NA" /idTUdmin="U3086" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3625373..3625392) /Source="Nicolas_upshift_promotors" /id="U3086" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96103896103896" /psig="0.995004995004995" /xcortree=1926 /SigmaFactorBS="aggcatttatcgatgcggttgctgctcatcgccattgGGATA GACgaatttgatcggcTCCTGTATCTTTAAGGAAGAtacttttcataaggagcatgac a" /listShort="yxiS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3625390) /Source="Nicolas_upshifts" /id="U3086" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96103896103896" /psig="0.995004995004995" /xcortree=1926 /SigmaFactorBS="aggcatttatcgatgcggttgctgctcatcgccattgGGATA GACgaatttgatcggcTCCTGTATCTTTAAGGAAGAtacttttcataaggagcatgac a" /listShort="yxiS" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3625398..3627458) /gene="katE" /locus_tag="BSU_39050" /old_locus_tag="BSU39050" /EC_number="1.11.1.6" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7559348, 8931328, 16151211" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7559348, 8931328, 16151211; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="catalase 2" /protein_id="NP_391784.2" /db_xref="EnsemblGenomes-Gn:BSU39050" /db_xref="EnsemblGenomes-Tr:CAB15931" /db_xref="GOA:P42234" /db_xref="InterPro:IPR002226" /db_xref="InterPro:IPR002818" /db_xref="InterPro:IPR010582" /db_xref="InterPro:IPR011614" /db_xref="InterPro:IPR018028" /db_xref="InterPro:IPR020835" /db_xref="InterPro:IPR024708" /db_xref="InterPro:IPR024712" /db_xref="InterPro:IPR029062" /db_xref="InterPro:IPR037060" /db_xref="SubtiList:BG11102" /db_xref="UniProtKB/Swiss-Prot:P42234" /translation="MSDDQNKRVNEHSKDEQLEQYRTDNSGKKMTTNQGLRVSEDEHS LKAGVRGPTLMEDFHFREKMTHFDHERIPERVVHARGFGVHGFFQVYEPMTEYTRAKF LQDPSVKTPVFVRFSTVAGSKGSADTVRDARGFATKFYTEEGNYDLVGNNIPVFFIQD AIKFPDLVHAFKPEPHNEMPQAATAHDTFWDFVANNPESAHMVMWTMSDRGIPRSYRM MEGFGVHTFRFVNEQGKARFVKFHWKPVLGVHSLVWDEAQKIAGKDPDFHRRDLWETI ENGGKVEYELGVQMIDEEDEFKFDFDILDPTKLWPEELVPVKIIGKMTLNRNQDNVFA ETEQVAFHPGNVVPGIDFTNDPLLQGRLFSYTDTQLIRLGGPNFHEIPINRPVCPFHN NQYDGYHRMTINKGPVAYHKNSLQNNDPSPATAEEGGYVHYQEKVEGKKIRQRSDSFN DYYSQAKLFWNSMSPVEKQHIISAFCFEVGKVKSKDVQRQVVDVFSNVDADLAEEIAK GVGVAAPAKRKASKEILTSPALSQARTVKTASTRKVAVLAGNGFHEKELQTVLEALKQ EGITVDIISQNLGYMTSGSGQQLEASGTFLTVDSVLYDAVYAAGGLELKDNKQAMAFI REAYNHYKAIGAANEGIDLLQSSVGTTEGLGIVTAKDEPDYTAFSKAFIDAVAAHRHW DRRI*" /label="katE CDS" gene complement(3625398..3627458) /gene="katE" /locus_tag="BSU_39050" /old_locus_tag="BSU39050" /label="katE gene" promotor_-35 complement(3625406..3625413) /Source="Nicolas_upshift_promotors" /id="U3086" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96103896103896" /psig="0.995004995004995" /xcortree=1926 /SigmaFactorBS="aggcatttatcgatgcggttgctgctcatcgccattgGGATA GACgaatttgatcggcTCCTGTATCTTTAAGGAAGAtacttttcataaggagcatgac a" /listShort="yxiS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3627487..3627505) /Source="Nicolas_upshift_promotors" /id="U3087" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=220 /SigmaFactorBS="caaaaatcctaatgagcggattagcAGTTTATatgaagaacg ccacGGGTAAATGTGCTGTAGAAtgtttcgttttaaaaagggggagcagacatgagtg a" /listShort="katE, yxiS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3627491) /Source="Nicolas_upshifts" /id="U3087" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=220 /SigmaFactorBS="caaaaatcctaatgagcggattagcAGTTTATatgaagaacg ccacGGGTAAATGTGCTGTAGAAtgtttcgttttaaaaagggggagcagacatgagtg a" /listShort="katE, yxiS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3627520..3627526) /Source="Nicolas_upshift_promotors" /id="U3087" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=220 /SigmaFactorBS="caaaaatcctaatgagcggattagcAGTTTATatgaagaacg ccacGGGTAAATGTGCTGTAGAAtgtttcgttttaaaaagggggagcagacatgagtg a" /listShort="katE, yxiS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3627551..3627556 /Source="Nicolas_upshift_promotors" /id="U3088" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1049 /SigmaFactorBS="cgttcttcatataaactgctaatccgctcattaggatttttG GTCTAcatataaatatgcggTCATACACATTTGAAATAAgccttcttcacagaaagaa a" /listShort="S1505, citH, S1506" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3627570 /Source="Nicolas_upshifts" /id="U3088" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1049 /SigmaFactorBS="cgttcttcatataaactgctaatccgctcattaggatttttG GTCTAcatataaatatgcggTCATACACATTTGAAATAAgccttcttcacagaaagaa a" /listShort="S1505, citH, S1506" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3627572..3627590 /Source="Nicolas_upshift_promotors" /id="U3088" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1049 /SigmaFactorBS="cgttcttcatataaactgctaatccgctcattaggatttttG GTCTAcatataaatatgcggTCATACACATTTGAAATAAgccttcttcacagaaagaa a" /listShort="S1505, citH, S1506" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3627584..3627658 /Source="Nicolas_S_feature" /locus_tag="new_4010329_4010403" /HighExp="S6, S5, S4, S8, S7, S3, M9-stat, LoTm, BT, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1505" CDS 3627659..3628939 /gene="citH" /locus_tag="BSU_39060" /old_locus_tag="BSU39060" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8892821, 11053381, 15849754, 16850406, 18556792" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8892821, 11053381, 15849754, 16850406, 18556792; Product type t : transporter" /codon_start=1 /transl_table=11 /product="secondary transporter of divalent metal ions/citrate complexes" /protein_id="NP_391785.2" /db_xref="EnsemblGenomes-Gn:BSU39060" /db_xref="EnsemblGenomes-Tr:CAB15932" /db_xref="GOA:P42308" /db_xref="InterPro:IPR004680" /db_xref="InterPro:IPR014738" /db_xref="SubtiList:BG11146" /db_xref="UniProtKB/Swiss-Prot:P42308" /translation="MLAILGFVMMIVFMYLIMSNRLSALIALIVVPIVFALISGFGKD LGEMMIQGVTDLAPTGIMLLFAILYFGIMIDSGLFDPLIAKILSFVKGDPLKIAVGTA VLTMTISLDGDGTTTYMITIAAMLPLYKRLGMNRLVLAGIAMLGSGVMNIIPWGGPTA RVLASLKLDTSEVFTPLIPAMIAGILWVIAVAYILGKKERKRLGVISIDHAPSSDPEA APLKRPALQWFNLLLTVALMAALITSLLPLPVLFMTAFAVALMVNYPNVKEQQKRISA HAGNALNVVSMVFAAGIFTGILSGTKMVDAMAHSLVSLIPDAMGPHLPLITAIVSMPF TFFMSNDAFYFGVLPIIAEAASAYGIDAAEIGRASLLGQPVHLLSPLVPSTYLLVGMA GVSFGDHQKFTIKWAVGTTIVMTIAALLIGIISF*" /label="citH CDS" gene 3627659..3628939 /gene="citH" /locus_tag="BSU_39060" /old_locus_tag="BSU39060" /label="citH gene" S_feature 3628940..3629079 /Source="Nicolas_S_feature" /locus_tag="new_4011685_4011824" /HighExp="S6, S5, S4, S8, S7, S3, M9-stat, BT, T5.0H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.382965" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1506" downshifts 3629036 /Source="Nicolas_upshifts" /id="D2033" /incds=0 /nref=3 /ntot=26 /MaxReadThrough="2.69139" /MaxDrop="3.50434" /score="10.8797157" /energy="-9" /TU="NA" /idTUdmin="U3088" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3629097..3629825) /gene="bglS" /locus_tag="BSU_39070" /old_locus_tag="BSU39070" /EC_number="3.2.1.73" /EC_number="3.2.1.6" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1369198, 3106158, 7704256, 20600285, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1369198, 3106158, 7704256, 20600285, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endo-beta-1,3-1,4 glucanase" /protein_id="NP_391786.1" /db_xref="EnsemblGenomes-Gn:BSU39070" /db_xref="EnsemblGenomes-Tr:CAB15943" /db_xref="GOA:P04957" /db_xref="InterPro:IPR000757" /db_xref="InterPro:IPR008263" /db_xref="InterPro:IPR008264" /db_xref="InterPro:IPR013320" /db_xref="PDB:3O5S" /db_xref="SubtiList:BG10476" /db_xref="UniProtKB/Swiss-Prot:P04957" /translation="MPYLKRVLLLLVTGLFMSLFAVTATASAQTGGSFFDPFNGYNSG FWQKADGYSNGNMFNCTWRANNVSMTSLGEMRLALTSPAYNKFDCGENRSVQTYGYGL YEVRMKPAKNTGIVSSFFTYTGPTDGTPWDEIDIEFLGKDTTKVQFNYYTNGAGNHEK IVDLGFDAANAYHTYAFDWQPNSIKWYVDGQLKHTATNQIPTTPGKIMMNLWNGTGVD EWLGSYNGVNPLYAHYDWVRYTKK*" /label="bglS CDS" gene complement(3629097..3629825) /gene="bglS" /locus_tag="BSU_39070" /old_locus_tag="BSU39070" /label="bglS gene" downshifts complement(3629114) /Source="Nicolas_upshifts" /id="D2034" /incds=0 /nref=64 /ntot=139 /MaxReadThrough="1.52649" /MaxDrop="6.38109" /score="-8.35070051" /energy="-16.3" /TU="NA" /idTUdmin="U3089" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3629856..3629875) /Source="Nicolas_upshift_promotors" /id="U3089" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.621378621378621" /psig=1 /xcortree=366 /SigmaFactorBS="tagtaagattcgatattatcattattttgacCGATGTTCcct tttaaaagaaTCATGTAAGATCAACATAGAaaacgctttcaatgaaaggggaatgcca a" /listShort="bglS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3629867) /Source="Nicolas_upshifts" /id="U3089" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.621378621378621" /psig=1 /xcortree=366 /SigmaFactorBS="tagtaagattcgatattatcattattttgacCGATGTTCcct tttaaaagaaTCATGTAAGATCAACATAGAaaacgctttcaatgaaaggggaatgcca a" /listShort="bglS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3629889..3629896) /Source="Nicolas_upshift_promotors" /id="U3089" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.621378621378621" /psig=1 /xcortree=366 /SigmaFactorBS="tagtaagattcgatattatcattattttgacCGATGTTCcct tttaaaagaaTCATGTAAGATCAACATAGAaaacgctttcaatgaaaggggaatgcca a" /listShort="bglS" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3630013..3630120) /Source="Nicolas_S_feature" /locus_tag="new_4012758_4012865_c" /HighExp="Sw, LPhT, T0.30H, M0t90, M9-stat, M40t90, Lbtran, Lbstat, S2, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1507" downshifts complement(3630056) /Source="Nicolas_upshifts" /id="D2035" /incds=0 /nref=21 /ntot=184 /MaxReadThrough="3.35114" /MaxDrop="4.38508" /score="-8.35070051" /energy="-16.3" /TU="U3090,U3091" /idTUdmin="U3091" /TUdmin="-174" /isTUend="FALSE" /label="downshifts" CDS complement(3630121..3630954) /gene="licT" /locus_tag="BSU_39080" /old_locus_tag="BSU39080" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11447120, 11580842, 11733988, 12169607, 15699035, 21278164, 23475962, 28235843" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11447120, 11580842, 11733988, 12169607, 15699035, 21278164, 23475962, 28235843; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional antiterminator (BglG family)" /protein_id="NP_391787.2" /db_xref="EnsemblGenomes-Gn:BSU39080" /db_xref="EnsemblGenomes-Tr:CAB15944" /db_xref="GOA:P39805" /db_xref="InterPro:IPR001550" /db_xref="InterPro:IPR004341" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR036634" /db_xref="InterPro:IPR036650" /db_xref="PDB:1H99" /db_xref="PDB:1L1C" /db_xref="PDB:1TLV" /db_xref="SubtiList:BG10474" /db_xref="UniProtKB/Swiss-Prot:P39805" /translation="MKIAKVINNNVISVVNEQGKELVVMGRGLAFQKKSGDDVDEARI EKVFTLDNKDVSEKFKTLLYDIPIECMEVSEEIISYAKLQLGKKLNDSIYVSLTDHIN FAIQRNQKGLDIKNALLWETKRLYKDEFAIGKEALVMVKNKTGVSLPEDEAGFIALHI VNAELNEEMPNIINITKVMQEILSIVKYHFKIEFNEESLHYYRFVTHLKFFAQRLFNG THMESQDDFLLDTVKEKYHRAYECTKKIQTYIEREYEHKLTSDELLYLTIHIERVVKQ A*" /label="licT CDS" gene complement(3630121..3630954) /gene="licT" /locus_tag="BSU_39080" /old_locus_tag="BSU39080" /label="licT gene" promotor_-10 complement(3630985..3631004) /Source="Nicolas_upshift_promotors" /id="U3090" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2725 /SigmaFactorBS="agtgaattgtactgaccagcttccgtctttccctgatgaTAT TGACCtagtacaaaaagaATGTACAATCAAGATATAGTctgttcttagtagatttgga g" /listShort="licT, S1507, bglS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3631004) /Source="Nicolas_upshifts" /id="U3090" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2725 /SigmaFactorBS="agtgaattgtactgaccagcttccgtctttccctgatgaTAT TGACCtagtacaaaaagaATGTACAATCAAGATATAGTctgttcttagtagatttgga g" /listShort="licT, S1507, bglS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3631018..3631025) /Source="Nicolas_upshift_promotors" /id="U3090" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2725 /SigmaFactorBS="agtgaattgtactgaccagcttccgtctttccctgatgaTAT TGACCtagtacaaaaagaATGTACAATCAAGATATAGTctgttcttagtagatttgga g" /listShort="licT, S1507, bglS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3631050..3631730) /gene="yxiP" /locus_tag="BSU_39090" /old_locus_tag="BSU39090" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_391788.1" /db_xref="EnsemblGenomes-Gn:BSU39090" /db_xref="EnsemblGenomes-Tr:CAB15945" /db_xref="SubtiList:BG11145" /db_xref="UniProtKB/Swiss-Prot:P42307" /translation="MRRIGLCISLLVTVLVMSACESEGEAQMFADCDQKTVKQTAAKP MSSKKKQDFQALASDRQLAIVFSSMIQVSEAFDYGIGNPEYFVRISMTEEEADIAKEN LESIKLENKSLKKQNSEAVALLQKTRNQDMSRIEIQQLTENRAGFFETADSMIKLINQ VTPKNAKKTRQQLDQLKKQYTQYSAESIKIMNSIVKKQKADKASFERHLEALLQKQPG QQVRSELY*" /label="yxiP CDS" gene complement(3631050..3631730) /gene="yxiP" /locus_tag="BSU_39090" /old_locus_tag="BSU39090" /label="yxiP gene" promotor_-10 complement(3631777..3631796) /Source="Nicolas_upshift_promotors" /id="U3091" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.54045954045954" /psig=1 /xcortree=2984 /SigmaFactorBS="gttttttcgcttcaaatcatacttttgatTTATTGCTggggt taggtgcaTCTGGTACCATTTAACTATAttttatggtattttccagaagggattcagc a" /listShort="yxiP, licT, S1507" /listLong="bglS" /label="promotor_-10" upshifts complement(3631786) /Source="Nicolas_upshifts" /id="U3091" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.54045954045954" /psig=1 /xcortree=2984 /SigmaFactorBS="gttttttcgcttcaaatcatacttttgatTTATTGCTggggt taggtgcaTCTGGTACCATTTAACTATAttttatggtattttccagaagggattcagc a" /listShort="yxiP, licT, S1507" /listLong="bglS" /label="upshifts" promotor_-35 complement(3631810..3631817) /Source="Nicolas_upshift_promotors" /id="U3091" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.54045954045954" /psig=1 /xcortree=2984 /SigmaFactorBS="gttttttcgcttcaaatcatacttttgatTTATTGCTggggt taggtgcaTCTGGTACCATTTAACTATAttttatggtattttccagaagggattcagc a" /listShort="yxiP, licT, S1507" /listLong="bglS" /label="promotor_-35" promotor_-35 3631878..3631881 /Source="Nicolas_upshift_promotors" /id="U3092" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.818181818181818" /psig="0.94005994005994" /xcortree=674 /SigmaFactorBS="agcgaaaaaacataaatattttgtaaaaattgacgtgcattc CATTcttttcaggcccatTTCTCGTACAATAGAAGTATcgttaccggagaggggctct g" /listShort="yxiO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3631896..3631915 /Source="Nicolas_upshift_promotors" /id="U3092" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.818181818181818" /psig="0.94005994005994" /xcortree=674 /SigmaFactorBS="agcgaaaaaacataaatattttgtaaaaattgacgtgcattc CATTcttttcaggcccatTTCTCGTACAATAGAAGTATcgttaccggagaggggctct g" /listShort="yxiO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3631896 /Source="Nicolas_upshifts" /id="U3092" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.818181818181818" /psig="0.94005994005994" /xcortree=674 /SigmaFactorBS="agcgaaaaaacataaatattttgtaaaaattgacgtgcattc CATTcttttcaggcccatTTCTCGTACAATAGAAGTATcgttaccggagaggggctct g" /listShort="yxiO" /GFF_Attribute="listLong" /label="upshifts" CDS 3631937..3633223 /gene="yxiO" /locus_tag="BSU_39100" /old_locus_tag="BSU39100" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12583894, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_391789.1" /db_xref="EnsemblGenomes-Gn:BSU39100" /db_xref="EnsemblGenomes-Tr:CAB15946" /db_xref="GOA:P42306" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR024671" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11144" /db_xref="UniProtKB/Swiss-Prot:P42306" /translation="MMKRFTKQENSWVLYDWANSAYSIVVTTAVFPLFYKSAAAESGV SAAQSTAYLGYTIAISTFILAMLGPILGTIADYEGCKKKFFGFFVSAGVASTAMLAFI PSEHWLLLLLFYTVSAIGFSGANVFYDAFLVDVTPEKRMNLVSARGFGLGYIGSTIPF IISIAVILLAQAETIPVSVSAASQLSFFITAAWWGLFTIPMIKHVHQRYYIKKEPHIV INSFKRLGQTMKRIRQYRALFLFLLAYFFYIDGVGTIITMSTSYGSDLGIGSSSLLII LFVTQVVAAPFSIIYGKLAERFTGKTMLYVGIVIYMIVCVYAYFMETTLDFWILAMLV ATSQGGIQALSRSYFAKLVPKRHANEFFGFYNIFGKFASIMGPLLIAVTAQLTGKSST AVFSLIILFVIGIVILAFVPEETSTDVSQQQNDLPL*" /label="yxiO CDS" gene 3631937..3633223 /gene="yxiO" /locus_tag="BSU_39100" /old_locus_tag="BSU39100" /label="yxiO gene" promotor_-10 complement(3632668..3632686) /Source="Nicolas_upshift_promotors" /id="U3093" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2817 /SigmaFactorBS="cctaaatctgatccataggatgtcgacatCGTAATAAtcgtg ccgactccGTCGATATAAAAGAAATAAgcgagcaagaagaggaaaagtgcccggtatt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3632676) /Source="Nicolas_upshifts" /id="U3093" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2817 /SigmaFactorBS="cctaaatctgatccataggatgtcgacatCGTAATAAtcgtg ccgactccGTCGATATAAAAGAAATAAgcgagcaagaagaggaaaagtgcccggtatt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3632700..3632707) /Source="Nicolas_upshift_promotors" /id="U3093" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2817 /SigmaFactorBS="cctaaatctgatccataggatgtcgacatCGTAATAAtcgtg ccgactccGTCGATATAAAAGAAATAAgcgagcaagaagaggaaaagtgcccggtatt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3633194 /Source="Nicolas_upshifts" /id="D2036" /incds=0 /nref=1 /ntot=68 /MaxReadThrough="2.50578" /MaxDrop="3.06646" /score="-7.45683354" /energy="-16.7" /TU="NA" /idTUdmin="U3092" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3633242..3634681) /gene="deaD" /locus_tag="BSU_39110" /old_locus_tag="BSU39110" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10481020, 16118224, 16611943, 17142894, 17229151, 17951299, 19839642, 20691700, 26755693" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10481020, 16118224, 16611943, 17142894, 17229151, 17951299, 19839642, 20691700, 26755693; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent RNA helicase for 23S ribosomal RNAmaturation" /protein_id="NP_391790.2" /db_xref="EnsemblGenomes-Gn:BSU39110" /db_xref="EnsemblGenomes-Tr:CAB15947" /db_xref="GOA:P42305" /db_xref="InterPro:IPR000629" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR005580" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR014014" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR028619" /db_xref="PDB:2G0C" /db_xref="PDB:2HJV" /db_xref="PDB:3MOJ" /db_xref="SubtiList:BG11143" /db_xref="UniProtKB/Swiss-Prot:P42305" /translation="MSHFKNYQISHDILRALEGLGYTEPTKVQQSVIPAALERKDLVV KSQTGSGKTASFGIPLCELANWDENKPQALILTPTRELAVQVKEDITNIGRFKRIKAT AVFGKSSFDKQKAELKQKSHIVVGTPGRVLDHIEKGTLPLDRLSYLVIDEADEMLNMG FIEQVEAIIKHLPTERTTMLFSATLPQDIEKLSRQYMQNPEHIEVKAAGLTTRNIEHA VIQVREENKFSLLKDVLMTENPDSCIIFCRTKEHVNQLTDELDDLGYPCDKIHGGMIQ EDRFDVMNEFKRGEYRYLVATDVAARGIDIENISLVINYDLPLEKESYVHRTGRTGRA GNKGKAISFVTAFEKRFLADIEEYIGFEIQKIEAPSQEEVARKKPEFLAKLNDRPESK KDKSEELNKDIMKLYFNGGKKKKIRAVDFVGTIAKIDGVSADDIGIITIMDNASYVEI LNGKGPHVLKVMKNTTVKGKQLKVNKANK*" /label="deaD CDS" gene complement(3633242..3634681) /gene="deaD" /locus_tag="BSU_39110" /old_locus_tag="BSU39110" /label="deaD gene" downshifts complement(3633265) /Source="Nicolas_upshifts" /id="D2037" /incds=0 /nref=200 /ntot=269 /MaxReadThrough="1.50578" /MaxDrop="5.83238" /score="3.28924902" /energy="-18.2" /TU="NA" /idTUdmin="U3095" /TUdmin=5 /isTUend="TRUE" /label="downshifts" misc_feature complement(3634705..3634724) /Source="Nicolas_upshift_promotors" /id="U3094" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.496503496503497" /psig="0.56943056943057" /xcortree=1449 /SigmaFactorBS="agggaatcgctggcttttaatacatcatttttcgacaaaaca catatgccttggtcaaTTAGAGTATAATGAGAACATctgcaagagacaggagtttata c" /listShort="deaD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3634722) /Source="Nicolas_upshifts" /id="U3094" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.496503496503497" /psig="0.56943056943057" /xcortree=1449 /SigmaFactorBS="agggaatcgctggcttttaatacatcatttttcgacaaaaca catatgccttggtcaaTTAGAGTATAATGAGAACATctgcaagagacaggagtttata c" /listShort="deaD" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3634763..3635911) /gene="yxiM" /locus_tag="BSU_39120" /old_locus_tag="BSU39120" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 10746760, 25394512; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="esterase (lipoprotein)" /protein_id="NP_391791.2" /db_xref="EnsemblGenomes-Gn:BSU39120" /db_xref="EnsemblGenomes-Tr:CAB15948" /db_xref="GOA:P42304" /db_xref="InterPro:IPR008979" /db_xref="InterPro:IPR013830" /db_xref="InterPro:IPR036514" /db_xref="PDB:2O14" /db_xref="SubtiList:BG11142" /db_xref="UniProtKB/Swiss-Prot:P42304" /translation="MKKWMAAVFVMMLMLCFGGIENVKAAEPKVYQFDFGSGSMEPGY IGVRASDRYDRSKGYGFQTPENMRDVAASGAGVKSDAVQFLAYGTKSNNTFNVDLPNG LYEVKVTLGNTARASVAAEGVFQVINMTGDGAEDTFQIPVTDGQLNLLVTEGKAGTAF TLSALKIKKLSDQPVTNRTIYVGGDSTVCNYYPLNSSKQAGWGQMLPHYIDKHTFQVR NMASGGQIARGFRNDGQLEAILKYIKPGDYFMLQLGINDTNPKHKESEAEFKEVMRDM IRQVKAKGADVILSTPQGRATDFTSEGIHSSVNRWYRASILALAEEEKTYLIDLNVLS SAYFTSIGPERTLGLYMDGDTLHPNRAGADALARLAVQELKRQGIAGF*" /label="yxiM CDS" gene complement(3634763..3635911) /gene="yxiM" /locus_tag="BSU_39120" /old_locus_tag="BSU39120" /label="yxiM gene" promotor_-10 complement(3635938..3635954) /Source="Nicolas_upshift_promotors" /id="U3095" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.466533466533467" /psig="0.466533466533467" /xcortree=812 /SigmaFactorBS="catttttattcctcaacgcaatttttttcttaattcagtcAT CATAaagaaacaatcaccGAGTATGCATTAATGTAttcgttttcatagagggggagtc t" /listShort="yxiM, deaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3635954) /Source="Nicolas_upshifts" /id="U3095" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.466533466533467" /psig="0.466533466533467" /xcortree=812 /SigmaFactorBS="catttttattcctcaacgcaatttttttcttaattcagtcAT CATAaagaaacaatcaccGAGTATGCATTAATGTAttcgttttcatagagggggagtc t" /listShort="yxiM, deaD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3635956..3636040) /Source="Nicolas_S_feature" /locus_tag="new_4018701_4018785_c" /HighExp="T3.30H, T4.0H, T2.30H, T3.0H, T2.0H, T-3.40H, T5.0H, T-2.40H, Lbexp, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1508" promotor_-35 complement(3635969..3635974) /Source="Nicolas_upshift_promotors" /id="U3095" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.466533466533467" /psig="0.466533466533467" /xcortree=812 /SigmaFactorBS="catttttattcctcaacgcaatttttttcttaattcagtcAT CATAaagaaacaatcaccGAGTATGCATTAATGTAttcgttttcatagagggggagtc t" /listShort="yxiM, deaD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3636041..3636229) /gene="yxzI" /locus_tag="BSU_39129" /old_locus_tag="BSU39129" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:CAX52710.1" /translation="MRFENISASKLDDLESIDSVALEIVPTDDQWERLRYYVYDEENQ ISFYCGGWDVIKCDKKSH*" /label="yxzI CDS" gene complement(3636041..3636229) /gene="yxzI" /locus_tag="BSU_39129" /old_locus_tag="BSU39129" /pseudo /label="yxzI gene" CDS complement(3636260..3636391) /gene="yxzJ" /locus_tag="BSU_39139" /old_locus_tag="BSU39139" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097796.1" /db_xref="EnsemblGenomes-Gn:BSU39139" /db_xref="EnsemblGenomes-Tr:CAX52711" /db_xref="UniProtKB/Swiss-Prot:C0H3T5" /translation="MNITQYEKLKQHLSDEDTGPFTLNEFSFYMKEDDRYIHIPVFE* " /label="yxzJ CDS" gene complement(3636260..3636391) /gene="yxzJ" /locus_tag="BSU_39139" /old_locus_tag="BSU39139" /label="yxzJ gene" CDS complement(3636403..3636864) /gene="yxiK" /locus_tag="BSU_39140" /old_locus_tag="BSU39140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type f: factor" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391793.1" /db_xref="EnsemblGenomes-Gn:BSU39140" /db_xref="EnsemblGenomes-Tr:CAB15950" /db_xref="SubtiList:BG11140" /db_xref="UniProtKB/Swiss-Prot:P42302" /translation="MEITSISSIGNLDMIELKPDQTVMACELEDAESFYRFWAGLAYD RIMIQVITTGSFIEDLSEYFEGHAYKVTKLAKREFHFQSILQEADRDIADFLFLLASI NDDVFLITDPQPDKSYFSEGKLQCLTDSGERIIWFEYDAVDIYMIGGESYK*" /label="yxiK CDS" gene complement(3636403..3636864) /gene="yxiK" /locus_tag="BSU_39140" /old_locus_tag="BSU39140" /label="yxiK gene" CDS complement(3636880..3637176) /gene="yxiJ" /locus_tag="BSU_39150" /old_locus_tag="BSU39150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391794.1" /db_xref="EnsemblGenomes-Gn:BSU39150" /db_xref="EnsemblGenomes-Tr:CAB15951" /db_xref="InterPro:IPR025551" /db_xref="SubtiList:BG11139" /db_xref="UniProtKB/Swiss-Prot:P42320" /translation="MLQKLRKRQRELEEKQYPDELYGFEAEIYEFFMLVAGSLDYVLA NKRIPRHQRRSLEKSFFELYPDILPDMIKNDKDLYHHILLYEQVRQEICVALSN*" /label="yxiJ CDS" gene complement(3636880..3637176) /gene="yxiJ" /locus_tag="BSU_39150" /old_locus_tag="BSU39150" /label="yxiJ gene" CDS complement(3637204..3637692) /gene="yxiI" /locus_tag="BSU_39160" /old_locus_tag="BSU39160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391795.1" /db_xref="EnsemblGenomes-Gn:BSU39160" /db_xref="EnsemblGenomes-Tr:CAB15952" /db_xref="InterPro:IPR020323" /db_xref="SubtiList:BG11138" /db_xref="UniProtKB/Swiss-Prot:P42301" /translation="MMNWRALSQTKQDRIWSEVNKIIKWKPGSRCHHIIPPDPYRVFD ISSAMSSKAGHNDVSGVLSDLETSILKAFQLGTGKNDVMYALDWQHDGYTFSPHQAMP KDEFGEWPVPVFPNGDYYFFFHQDFSWGLLGDPWKCAITVFGEELLEAIDNDPPILFR NK*" /label="yxiI CDS" gene complement(3637204..3637692) /gene="yxiI" /locus_tag="BSU_39160" /old_locus_tag="BSU39160" /label="yxiI gene" CDS complement(3637710..3638162) /gene="yxzG" /locus_tag="BSU_39170" /old_locus_tag="BSU39170" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative nucleic acid binding protein" /protein_id="NP_391796.1" /db_xref="EnsemblGenomes-Gn:BSU39170" /db_xref="EnsemblGenomes-Tr:CAB15953" /db_xref="SubtiList:BG14170" /db_xref="UniProtKB/Swiss-Prot:O32285" /translation="MWCFTLDGQQKEIHIDRKLEEMDAPAVDDCYGLAEKNGLIYMLY YGDAVIAAFDETVVRRVWILSDKEPDSEAFDQLAISEEGFLVGTFNCYSADLKSSLYL ISADVSQEMEEITCCDSNGEGLDVQQLKLTSYAVYAVASSGVYKQDIQ*" /label="yxzG CDS" gene complement(3637710..3638162) /gene="yxzG" /locus_tag="BSU_39170" /old_locus_tag="BSU39170" /label="yxzG gene" S_feature complement(3638163..3638231) /Source="Nicolas_S_feature" /locus_tag="new_4020908_4020976_c" /HighExp="T4.0H, T3.30H, T3.0H, T2.30H, T2.0H, T-3.40H, T5.0H, T-2.40H, T-4.40H, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.19384199999999999" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1509" CDS complement(3638232..3638561) /gene="yxiH" /locus_tag="BSU_39180" /old_locus_tag="BSU39180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391797.1" /db_xref="EnsemblGenomes-Gn:BSU39180" /db_xref="EnsemblGenomes-Tr:CAB15954" /db_xref="InterPro:IPR011042" /db_xref="SubtiList:BG11137" /db_xref="UniProtKB/Swiss-Prot:P42300" /translation="MKKLKLNKIINENTQDCFFHADPQGRVYIGKGLKGGITITIYDP SGDVRDFRVKEQISYSDILLFQQCADGYVFVYYESYEPKVKVFSEEGRVKSVFHLPSG VSCCLLD*" /label="yxiH CDS" gene complement(3638232..3638561) /gene="yxiH" /locus_tag="BSU_39180" /old_locus_tag="BSU39180" /label="yxiH gene" S_feature complement(3638562..3638683) /Source="Nicolas_S_feature" /locus_tag="new_4021307_4021428_c" /HighExp="T3.30H, T4.0H, T3.0H, T2.30H, T-4.40H, T-3.40H, LBGexp, T-2.40H, T2.0H, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1510" CDS complement(3638684..3639100) /gene="yxiG" /locus_tag="BSU_39190" /old_locus_tag="BSU39190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391798.1" /db_xref="EnsemblGenomes-Gn:BSU39190" /db_xref="EnsemblGenomes-Tr:CAB15955" /db_xref="SubtiList:BG11136" /db_xref="UniProtKB/Swiss-Prot:P42299" /translation="MTMYQTINEWVDYIDKGCSVLHLDFNVFKKELSLDIKVFEDEGE YTHKISFQNVASAYYSADVGDMRLEKIDPEEYNWQVFEMSYHPEGIGNLSNSIIPEYQ SNANFLIDMNRMLIAIEAETVRFDDQSFYAYQLNTK*" /label="yxiG CDS" gene complement(3638684..3639100) /gene="yxiG" /locus_tag="BSU_39190" /old_locus_tag="BSU39190" /label="yxiG gene" CDS complement(3639151..3639519) /gene="yxzC" /locus_tag="BSU_39200" /old_locus_tag="BSU39200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative nucleic acid binding protein" /protein_id="NP_391799.1" /db_xref="EnsemblGenomes-Gn:BSU39200" /db_xref="EnsemblGenomes-Tr:CAB15956" /db_xref="SubtiList:BG14167" /db_xref="UniProtKB/Swiss-Prot:O32286" /translation="MVDWKPFGTYLLRKKLQYLNISTVLCILIKNHLVLEYVVIKLSE TNLIECINKIKSVLNGQTTREEVSDWAGTYVYADDPEVEDDRVWDMLILLSGIDLKDS SETYLHSTDDLNDWIKQYTE*" /label="yxzC CDS" gene complement(3639151..3639519) /gene="yxzC" /locus_tag="BSU_39200" /old_locus_tag="BSU39200" /label="yxzC gene" CDS complement(3639513..3639983) /gene="yxiF" /locus_tag="BSU_39210" /old_locus_tag="BSU39210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391800.1" /db_xref="EnsemblGenomes-Gn:BSU39210" /db_xref="EnsemblGenomes-Tr:CAB15957" /db_xref="SubtiList:BG11135" /db_xref="UniProtKB/Swiss-Prot:P42298" /translation="MQKRLIEKLAENKRRLLMSEIKEKLVPCAERGFTYRFADLAQSR QLLELVLSNSIPANTREVDALEKTEAKQLIWKISQSYVAYDDRDVLLFHQYSSEIGAL VCSFGKCLEHLDCLLECIEFDEGILNHSFILVEPKCQFGLCILHTEYGCELVYW*" /label="yxiF CDS" gene complement(3639513..3639983) /gene="yxiF" /locus_tag="BSU_39210" /old_locus_tag="BSU39210" /label="yxiF gene" S_feature complement(3639984..3640308) /Source="Nicolas_S_feature" /locus_tag="new_4022729_4023053_c" /HighExp="T3.30H, T-2.40H, T2.30H, T3.0H, T4.0H, SMMPr, MG 120, C90, T2.0H, T-4.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1511" CDS complement(3640309..3640737) /gene="wapI" /locus_tag="BSU_39220" /old_locus_tag="BSU39220" /experiment="publication(s) with functional evidences, PMID:1529529, 16306698, 19763274, 23572593" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1529529, 16306698, 19763274, 23572593; Product type f: factor" /codon_start=1 /transl_table=11 /product="antitoxin of WapA tRNase" /protein_id="NP_391801.1" /db_xref="EnsemblGenomes-Gn:BSU39220" /db_xref="EnsemblGenomes-Tr:CAB15958" /db_xref="SubtiList:BG10798" /db_xref="UniProtKB/Swiss-Prot:Q07836" /translation="MAKIKDDCIELELTPRRYQELDDDPFILSVFELLENKKAVVRDF SAVLLESEYKVLISGIETMIKGNQDSISLETIEPFLFLSIDQENGNYRIKIKIIFDDY KESKSNSNLFEINCNEEKLESFVTALKLNLENTKNPSKLP*" /label="wapI CDS" gene complement(3640309..3640737) /gene="wapI" /locus_tag="BSU_39220" /old_locus_tag="BSU39220" /label="wapI gene" CDS complement(3640799..3647803) /gene="wapA" /locus_tag="BSU_39230" /old_locus_tag="BSU39230" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8316082, 9537385, 16306698, 16849803, 21636651, 23199363, 23572593, 23944997, 25666134, 28827522" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8316082, 9537385, 16306698, 16849803, 21636651, 23199363, 23572593, 23944997, 25666134, 28827522; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cell wall-associated tRNA nuclease precursor; intercellular growth inhibitor" /protein_id="NP_391802.2" /db_xref="EnsemblGenomes-Gn:BSU39230" /db_xref="EnsemblGenomes-Tr:CAB15959" /db_xref="GOA:Q07833" /db_xref="InterPro:IPR006530" /db_xref="InterPro:IPR008979" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR022385" /db_xref="InterPro:IPR031325" /db_xref="SubtiList:BG10797" /db_xref="UniProtKB/Swiss-Prot:Q07833" /translation="MKKRKRRNFKRFIAAFLVLALMISLVPADVLAKSTEEENGNRIA ADDPEETLQKEQTEEAVPFDPKDINKEGEITSERTENTKLYYEGDGVYKQEVYLDPIH TKETPDADWEDISPELKESTSKQVETENAILNSDFQKQMKNGLYATFEHNDHKVTYSL AEAKGPNKTSLTPKDTSADYKTDSNEIVYPDVFPNIDLQTFTFNENIKEDLVLHQYNG YNTFTFQLKTDLQAKEQEDGSIDFSDEKGKVVFSVPKPFMTDSKLDELSGEVERSDKV SYKLEKNEEGYLLHLTADENWLKDPERVYPVSIDPSTSLSVSSDTFVMSAYPTTNYSA SSQKWDANLKAYVLKTGYYDKTTGTNYAFMKFNNLKPIQNMTVTKATLKTYVAHSYYG TKATGLWLDTVNSNYDNAKVTWNTKPASKNIGKADVHKGQWASYDVTAAVKSWNSGGA NYGFKLHTNGNGKEYWKKLISSANSANKPYIEVTYTIPKGNTPTIKAYHNGDSTGYFD ISWKKVEGAKGYKVWIYNGKEYQAISAGNVTSWSTKGKKIWPTSAEIASKRYKLHLDG KDGAELALDPSPVYKNSGGSYATSKNYWIGVSAIFDQGEGAMSAPAKPVIPNVGKAQA PSAKGYNNGNATGYFDLSWKAVSGATGYKVQVFNGKGFETLDLGNQTSWTTKGKKIWP TSAEIKAGKYALHLKDGSGAELPINPGPTYKNAGGDGAKRNYSFKIIAYNKDGEAIAS PAATPALPDIARPKNVTGYLYTNTKSSQTGYVNLIWEKVQNAKGYKVNIYNGKEYQSF DVGDADHWTTQNKNIWPTSEEIKAGSYKLHTDGKGGELALDPSPVYNNANGNYKGKKN YSFTLVAYDANGETIPTAPFNPTFHEGAEFLGTEEYWSIIDIPSGQLNGATGNVIVNE EDLSIDGRGPGLGLSRTYNSLDSSDHLFGQGWYADAETSVISTDGGAMYIDEDATTHR FTKKADGTYQPPTGVYLELTETADQFILKTKDQTNAYFNKKGGKLQKVVDGHNNATVY TYNDKNQLTAITDASGRKLTFTYDENGHVTSITGPKNKKVTYSYENDLLKKVTDTDGT VTSYDYDSEGRLVKQYSANSTEAKPVFTEYQYSGHRLEKAINAKKETYVYSYDADKKT LLMTQPNGRKVQYGYNEAGNPIQVIDDAEGLKITTNTKYEGNNVVEDVDPNDVGTGKA TESYQYDKDGNVTSVKDAYGTETYEYNKNNDVTKMKDTEGNVTDIAYDGLDAVSETDQ SGKSSSAAVYDKYGNQIQSSKDLSASTNILKDGSFEAQKSGWNLTASKDSGKISVIAD KSGVLSGSKALEVLSQSTSAGTDHGYSSATQTVELEPNTTYTLSGKIKTDLAKSRAYF NIDLRDKDQKRIQWIHNEYSALAGKNDWTKRQITFTTPANAGKAVVYMEVDHKDKDGK GKAWFDEVQLEKGEVSSSYNPVQNSSFTSATENWNVSGASVDSEEGFNDDVSLKAART SASQAGSVTKQTVVLGQSANDKPVYLTLTGMSKASSVKFTDEKDYSLQANVTYADGST GIYNAKFPSGTQEWNRAAVVIPKTKPINKVDISILFQKSATGTVWFDDIRLIEGSLLT KSTYDSNGNYVTKEEDELGYATSTDYDETGKKTSETDAKGEKTTYTYDQADQLTNMTL SNGTSILHSYDKEGNEVSKTIRAGADQTYKFEYDVMGKLVKTTDPLGNVLASEYDANS NLTKTISPNGNEVSLSYDGTDRVKSKSYNGTEKYIFTYDKNGNETSVVNKEQNTTKKR TFDNKNRLTELTDRGGSQTWTYPSDSDKLKTFSWIHGDQKGTNQFTYNKLDQMIEMKD STSSYSFDYDENGNVQTFITGNGGGTSFSYDERNLVSSLHIGDKNGGDILTESYEYDA NGNRTTINSSASGKVQYEYGKLNQLVKETHEDGTVIEYTYDGFGNRKTVTTIKDGSSK TVNASFNIMNQLTKVNDESISYDKNGNRTSDGKFTYTWDAEDNLTAVTKKGEDKPFAT YKYDEKGNRIQKTVNGKVTNYFYDGDSLNVLYETDADNNVTKSYTYGDSGQLLSYTEN GKKYFYHYNAHGDIIAISDSTGKTVAKYQYDAWGNPTKTEASDEVKDNRYRYAGYQYD EETGLYYLMARYYEPRNGVFLSLDPDPGSDGDSLDQNGYAYGNNNPVMNVDPDGHWVW LVVNAGFAAYDGYKAYKSGKGWKGAAWAAASNFGPGKIFKGASRAYKFTKKAVKITGH TRHGLNQSIGRNGGRGVNLRAKLNAVRSPKKVIKQPNGATKYVGKKATVVLNKRGKVI TAYGSSRAKGSKHVFHTHGKGNKSKRRR*" /label="wapA CDS" gene complement(3640799..3647803) /gene="wapA" /locus_tag="BSU_39230" /old_locus_tag="BSU39230" /label="wapA gene" misc_feature 3647810..3647824 /Source="Nicolas_upshift_promotors" /id="U3096" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.896103896103896" /psig="0.0919080919080919" /xcortree=301 /SigmaFactorBS="caatgaaccttttaaagtttcgcctctttctttttttcattt cctcTCTCCTTTTGTAATAaaagtaatatttactcaataatcttaactagactgaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3647824 /Source="Nicolas_upshifts" /id="U3096" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.896103896103896" /psig="0.0919080919080919" /xcortree=301 /SigmaFactorBS="caatgaaccttttaaagtttcgcctctttctttttttcattt cctcTCTCCTTTTGTAATAaaagtaatatttactcaataatcttaactagactgaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3647834..3647853) /Source="Nicolas_upshift_promotors" /id="U3097" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.917082917082917" /psig=1 /xcortree=2783 /SigmaFactorBS="taatccttaaaataagataaattttctagaaaaaTATTGTAA tgatatttcagtctAGTTAAGATTATTGAGTAAAtattacttttattacaaaaggaga g" /listShort="wapA, yxxG, S1511, yxiF, yxzC, yxiG, S1510, yxiH, S1509, yxzG, yxiI, yxiJ, yxiK, yxzJ, yxzI, S1508, yxiM, deaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3647849) /Source="Nicolas_upshifts" /id="U3097" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.917082917082917" /psig=1 /xcortree=2783 /SigmaFactorBS="taatccttaaaataagataaattttctagaaaaaTATTGTAA tgatatttcagtctAGTTAAGATTATTGAGTAAAtattacttttattacaaaaggaga g" /listShort="wapA, yxxG, S1511, yxiF, yxzC, yxiG, S1510, yxiH, S1509, yxzG, yxiI, yxiJ, yxiK, yxzJ, yxzI, S1508, yxiM, deaD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3647868..3647875) /Source="Nicolas_upshift_promotors" /id="U3097" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.917082917082917" /psig=1 /xcortree=2783 /SigmaFactorBS="taatccttaaaataagataaattttctagaaaaaTATTGTAA tgatatttcagtctAGTTAAGATTATTGAGTAAAtattacttttattacaaaaggaga g" /listShort="wapA, yxxG, S1511, yxiF, yxzC, yxiG, S1510, yxiH, S1509, yxzG, yxiI, yxiJ, yxiK, yxzJ, yxzI, S1508, yxiM, deaD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3647965..3648900) /gene="yxxF" /locus_tag="BSU_39240" /old_locus_tag="BSU39240" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_391803.1" /db_xref="EnsemblGenomes-Gn:BSU39240" /db_xref="EnsemblGenomes-Tr:CAB15960" /db_xref="GOA:Q07835" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG10796" /db_xref="UniProtKB/Swiss-Prot:Q07835" /translation="MQQDPSISSKQKSTAVIKMVISMVIFGSIGFFSEHTNLPSFELV FVRCLCATLFLGFCWLASGQYKTEKWSKRDVLQTLACGFFLVFNWVFLFKSFEETSVT IAISVYHLAPVLVLLLGSFFYREKLNVISVSSIIICFLGTALISGINGSTSLTQLMGS GIIWAVLAALFYAFTTLLGKGIHNLSPYTTTFLQTGLGVIILIPFIHFGAFADLSQGN WIMVVSTGIIHTGIVYLLFFDSLRFLSTKFISIIVFLDPAVAIVLDTVFTGFRPDLYQ TLGIVMIFAGMALTLVRRQGKANVTAEGTDIEQIQ*" /label="yxxF CDS" gene complement(3647965..3648900) /gene="yxxF" /locus_tag="BSU_39240" /old_locus_tag="BSU39240" /label="yxxF gene" downshifts complement(3648186) /Source="Nicolas_upshifts" /id="D2038" /incds=1 /nref=1 /ntot=153 /MaxReadThrough="1.33481" /MaxDrop="2.42407" /score="29.0290332" /energy="-5.9" /TU="NA" /idTUdmin="U3098" /TUdmin=22 /isTUend="TRUE" /label="downshifts" S_feature complement(3648901..3649021) /Source="Nicolas_S_feature" /locus_tag="new_4031646_4031766_c" /HighExp="T3.0H, T1.0H, T3.30H, LBGstat, T1.30H, T0.30H, T4.0H, M9-stat, T2.30H, T0.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="Sig-" /TUlongPSig="0.196" /label="S1512" CDS complement(3649052..3649498) /gene="yxiE" /locus_tag="BSU_39250" /old_locus_tag="BSU39250" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10913081, 12644671, 17210127" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10913081, 12644671, 17210127; Product type f: factor" /codon_start=1 /transl_table=11 /product="phosphate starvation protein (universal stress protein A family)" /protein_id="NP_391804.1" /db_xref="EnsemblGenomes-Gn:BSU39250" /db_xref="EnsemblGenomes-Tr:CAB15961" /db_xref="GOA:P42297" /db_xref="InterPro:IPR006015" /db_xref="InterPro:IPR006016" /db_xref="InterPro:IPR014729" /db_xref="SubtiList:BG11134" /db_xref="UniProtKB/Swiss-Prot:P42297" /translation="MFNKMLVAIDGSDMSAKALDAAVHLAKEQQAELSILHVGREAVV TTSSLTGIVYVPEHFIDEIRNEVKKEGLKILENAKEKAAEKGVQAETIYANGEPAHEI LNHAKEKGVSLIVVGSRGISGLKEMMLGSVSHKVSQLSTCPVLIVR*" /label="yxiE CDS" gene complement(3649052..3649498) /gene="yxiE" /locus_tag="BSU_39250" /old_locus_tag="BSU39250" /label="yxiE gene" downshifts complement(3649066) /Source="Nicolas_upshifts" /id="D2039" /incds=0 /nref=22 /ntot=144 /MaxReadThrough="4.33955" /MaxDrop="6.75522" /score="45.6082379" /energy="-8.4" /TU="U3098" /idTUdmin="U3099" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3649535..3649554) /Source="Nicolas_upshift_promotors" /id="U3098" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.56943056943057" /psig="0.998001998001998" /xcortree=1609 /SigmaFactorBS="gacaattttttgaaaactcatgcgcttCAATTGACaataacg aaatgcAGGCGGACAATAAAAGAGAAagatgaaccacccacagtccgaaaggcgggaa g" /listShort="yxiE, S1512, yxxF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3649542) /Source="Nicolas_upshifts" /id="U3098" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.56943056943057" /psig="0.998001998001998" /xcortree=1609 /SigmaFactorBS="gacaattttttgaaaactcatgcgcttCAATTGACaataacg aaatgcAGGCGGACAATAAAAGAGAAagatgaaccacccacagtccgaaaggcgggaa g" /listShort="yxiE, S1512, yxxF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3649568..3649575) /Source="Nicolas_upshift_promotors" /id="U3098" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.56943056943057" /psig="0.998001998001998" /xcortree=1609 /SigmaFactorBS="gacaattttttgaaaactcatgcgcttCAATTGACaataacg aaatgcAGGCGGACAATAAAAGAGAAagatgaaccacccacagtccgaaaggcgggaa g" /listShort="yxiE, S1512, yxxF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3649601..3651010) /gene="bglH" /locus_tag="BSU_39260" /old_locus_tag="BSU39260" /EC_number="3.2.1.86" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14652714, 15139916" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14652714, 15139916; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aryl-phospho-beta-d-glucosidase" /protein_id="NP_391805.2" /db_xref="EnsemblGenomes-Gn:BSU39260" /db_xref="EnsemblGenomes-Tr:CAB15962" /db_xref="GOA:P40740" /db_xref="InterPro:IPR001360" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR018120" /db_xref="InterPro:IPR033132" /db_xref="SubtiList:BG10935" /db_xref="UniProtKB/Swiss-Prot:P40740" /translation="MSSNEKRFPEGFLWGGAVAANQVEGAYNEGGKGLSTADVSPNGI MSPFDESMTSLNLYHNGIDFYHRYKEDIALFAEMGFKAFRTSIAWTRIFPNGDEEEPN EEGLRFYDDLFDELLKHHIEPVVTISHYEMPLGLVKNYGGWKNRKVIEFYERYAKTVF KRYQHKVKYWMTFNEINVVLHAPFTGGGLVFEEGENKLNAMYQAAHHQFVASALAVKA GHDIIPDSKIGCMIAATTTYPMTSKPEDVFAAMENERKTLFFSDVQARGAYPGYMKRY LAENNIEIEMAEGDEELLKEHTVDYIGFSYYMSMAASTDPEELAKSGGNLLGGVKNPY LKSSEWGWQIDPKGLRITLNTLYDRYQKPLFIVENGLGAVDKVEEDGTIQDDYRINYL RDHLIEAREAIADGVELIGYTSWGPIDLVSASTAEMKKRYGFIYVDRDNEGNGTFNRI KKKSFNWYQQVIATNGESL*" /label="bglH CDS" gene complement(3649601..3651010) /gene="bglH" /locus_tag="BSU_39260" /old_locus_tag="BSU39260" /label="bglH gene" CDS complement(3651033..3652862) /gene="bglP" /locus_tag="BSU_39270" /old_locus_tag="BSU39270" /EC_number="2.7.1.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 17074746, 8626332" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 17074746, 8626332; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) beta-glucoside-specific enzyme IIBCA component" /protein_id="NP_391806.2" /db_xref="EnsemblGenomes-Gn:BSU39270" /db_xref="EnsemblGenomes-Tr:CAB15963" /db_xref="GOA:P40739" /db_xref="InterPro:IPR001127" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR011055" /db_xref="InterPro:IPR011297" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG10934" /db_xref="UniProtKB/Swiss-Prot:P40739" /translation="MDYDKLSKDILQLVGGEENVQRVIHCMTRLRFNLHDNAKADRSQ LEQLPGVMGTNISGEQFQIIIGNDVPKVYQAIVRHSNLSDEKSAGSSSQKKNVLSAVF DVISGVFTPILPAIAGAGMIKGLVALAVTFGWMAEKSQVHVILTAVGDGAFYFLPLLL AMSAARKFGSNPYVAAAIAAAILHPDLTALLGAGKPISFIGLPVTAATYSSTVIPILL SIWIASYVEKWIDRFTHASLKLIVVPTFTLLIVVPLTLITVGPLGAILGEYLSSGVNY LFDHAGLVAMILLAGTFSLIIMTGMHYAFVPIMINNIAQNGHDYLLPAMFLANMGQAG ASFAVFLRSRNKKFKSLALTTSITALMGITEPAMYGVNMRLKKPFAAALIGGAAGGAF YGMTGVASYIVGGNAGLPSIPVFIGPTFIYAMIGLVIAFAAGTAAAYLLGFEDVPSDG SQQPAVHEGSREIIHSPIKGEVKALSEVKDGVFSAGVMGKGFAIEPEEGEVVSPVRGS VTTIFKTKHAIGITSDQGAEILIHIGLDTVKLEGQWFTAHIKEGDKVAPGDPLVSFDL EQIKAAGYDVITPVIVTNTDQYSFSPVKEIGKVQPKEALLALS*" /label="bglP CDS" gene complement(3651033..3652862) /gene="bglP" /locus_tag="BSU_39270" /old_locus_tag="BSU39270" /label="bglP gene" promotor_no_box complement(3652854..3652954) /Source="Nicolas_upshift_promotors" /id="U3099" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.362637362637363" /psig="0.195804195804196" /xcortree=1562 /SigmaFactorBS="ttaggaggtgatgcagcatttgatacaaaaaaagctggtgaa aggcggccacctttcatccagcagtccccccataaaaaggaggtatacacatggatta t" /listShort="bglP, bglH, yxiE" /listLong="S1512, yxxF" /label="promotor_no_box" upshifts complement(3652894) /Source="Nicolas_upshifts" /id="U3099" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.362637362637363" /psig="0.195804195804196" /xcortree=1562 /SigmaFactorBS="ttaggaggtgatgcagcatttgatacaaaaaaagctggtgaa aggcggccacctttcatccagcagtccccccataaaaaggaggtatacacatggatta t" /listShort="bglP, bglH, yxiE" /listLong="S1512, yxxF" /label="upshifts" S_feature complement(3652896..3653088) /Source="Nicolas_S_feature" /locus_tag="new_4035641_4035833_c" /HighExp="Diami, T0.30H, B60, T0.0H, G150, M9-stat, T1.0H, T1.30H, Gly, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.29980099999999998" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.998, 0.994, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1513" promotor_-10 complement(3653069..3653088) /Source="Nicolas_upshift_promotors" /id="U3100" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.688311688311688" /psig="0.998001998001998" /xcortree=1563 /SigmaFactorBS="cttttgttctagaaacgatagtcaacaccaaaaatgaaagCG TTGACAtctcacgaatctAGTGCTAAAGTATACCTACAaacaaataaaacgacccgtc a" /listShort="S1513, bglP, bglH, yxiE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3653088) /Source="Nicolas_upshifts" /id="U3100" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.688311688311688" /psig="0.998001998001998" /xcortree=1563 /SigmaFactorBS="cttttgttctagaaacgatagtcaacaccaaaaatgaaagCG TTGACAtctcacgaatctAGTGCTAAAGTATACCTACAaacaaataaaacgacccgtc a" /listShort="S1513, bglP, bglH, yxiE" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3653090..3653223) /Source="Nicolas_S_feature" /locus_tag="new_4035835_4035968_c" /HighExp="S2, HiTm, Sw, S8, M9-stat, Lbstat, S0, T2.0H, Mal, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.994, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1514" promotor_-35 complement(3653101..3653108) /Source="Nicolas_upshift_promotors" /id="U3100" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.688311688311688" /psig="0.998001998001998" /xcortree=1563 /SigmaFactorBS="cttttgttctagaaacgatagtcaacaccaaaaatgaaagCG TTGACAtctcacgaatctAGTGCTAAAGTATACCTACAaacaaataaaacgacccgtc a" /listShort="S1513, bglP, bglH, yxiE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3653245..3653553) /gene="yxxE" /locus_tag="BSU_39280" /old_locus_tag="BSU39280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391807.1" /db_xref="EnsemblGenomes-Gn:BSU39280" /db_xref="EnsemblGenomes-Tr:CAB15964" /db_xref="SubtiList:BG11071" /db_xref="UniProtKB/Swiss-Prot:P40738" /translation="MLLINKQKDPVFQFLAGTFHQDIETPDDAIQELLIEESKEYLED AIVFLTDFIESEHSDNKKNDYIQSCADGVYLPAFNLEPIDWLKNVIVQIKKSLKKFKR *" /label="yxxE CDS" gene complement(3653245..3653553) /gene="yxxE" /locus_tag="BSU_39280" /old_locus_tag="BSU39280" /label="yxxE gene" downshifts complement(3653268) /Source="Nicolas_upshifts" /id="D2040" /incds=0 /nref=137 /ntot=221 /MaxReadThrough="3.99098" /MaxDrop="5.76651" /score="24.0715465" /energy="-21.3" /TU="U3101,U3102" /idTUdmin="U3101" /TUdmin="-3718" /isTUend="FALSE" /label="downshifts" CDS complement(3653599..3654042) /gene="rtbE" /locus_tag="BSU_39290" /old_locus_tag="BSU39290" /function="17: Mobile and extrachromosomal element functions" /experiment="publication(s) with functional evidences, PMID:22200572" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22200572; Product type f: factor" /codon_start=1 /transl_table=11 /product="antitoxin factor of the RttD-RttE toxin-antitoxin system" /protein_id="NP_391808.1" /db_xref="EnsemblGenomes-Gn:BSU39290" /db_xref="EnsemblGenomes-Tr:CAB15965" /db_xref="InterPro:IPR018958" /db_xref="SubtiList:BG11070" /db_xref="UniProtKB/Swiss-Prot:P40737" /translation="MSYNFIKSNKENDFYPVNQSEIEEVEKNLNLKLPSELVNFYLEV GYGFIKGSEFNTNRILDPYSVRDFRLRINDFEFYPDIEIYDEFENDKLIFFEGSESAL MSIELNDNNKNPIYYYDIQIATSLTEFLRKIEENDQYYLDLLDDE*" /label="rtbE CDS" gene complement(3653599..3654042) /gene="rtbE" /locus_tag="BSU_39290" /old_locus_tag="BSU39290" /label="rtbE gene" CDS complement(3654039..3655748) /gene="rtbD" /locus_tag="BSU_39300" /old_locus_tag="BSU39300" /function="17: Mobile and extrachromosomal element functions" /experiment="publication(s) with functional evidences, PMID:22200572" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22200572; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease toxin of the RtbD-RtbE toxin-antitoxin system" /protein_id="NP_391809.2" /db_xref="EnsemblGenomes-Gn:BSU39300" /db_xref="EnsemblGenomes-Tr:CAB15966" /db_xref="GOA:P42296" /db_xref="InterPro:IPR003615" /db_xref="InterPro:IPR006829" /db_xref="InterPro:IPR027797" /db_xref="SubtiList:BG11133" /db_xref="UniProtKB/Swiss-Prot:P42296" /translation="MKTLDVHALHEGIQHTIEKLDKQKQQLEKLEKSVEHLAGMKDAL KGKGGDAIRTFYEECHKPFLLFFGIFIDEYKKVLKQTQHAISSVESNSHGMIAEAFLS HDARHGVKHAREVTEQLTDAVNRQTSAIDHIVSLPTVNDSFFRMETEQAERLISDTLN KLFQFDGQQTQALEAAKSDFQTMKKYIDQLETMYTGPKIEITGYKSGSILKSQEEENI NQIFGAINPQMKQADDSPMEMMLKKLAENEKSKVDSVVKTGDSKKVSKNIIVINGKVY NTSEHREHIKTDFSNAEVKQVVYNDTLYNVYISGNDMKLEPVVSLSDIKVDENGYVKI LETAVELTGVYDLFKAATGRDPVSGEKVTGKDRVVASINSVPFAKIAKLEKLIDINKL INNGKKAKKASEVKNVAKDKGKIANDVSGSANKINSDLIKKYARDIEQRTGRELPKNQ IDKLKEALRNKEYKKMSPIETAKHRTKFDKVKNKVIKEWEENTGQKWPVYKENVVSEK TGKIIRKKGDKYDAHHIIENTFGGEHEWWNMHPAKFPNEHQAGIHGTGSPANELFKGG KKK*" /label="rtbD CDS" gene complement(3654039..3655748) /gene="rtbD" /locus_tag="BSU_39300" /old_locus_tag="BSU39300" /label="rtbD gene" misc_feature complement(3654910..3654929) /Source="Nicolas_upshift_promotors" /id="U3101" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.551448551448551" /psig="0.994005994005994" /xcortree=1873 /SigmaFactorBS="aacgggtgattctaaaaaggtaagtaaaaatatcatcgttat caatggtAAAGTGTATAATACGAGTGAacatagagaacatataaaaactgatttctca a" /listShort="yxxD, yxxE, S1514, S1513, bglP, bglH" /listLong="yxiE" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3654918) /Source="Nicolas_upshifts" /id="U3101" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.551448551448551" /psig="0.994005994005994" /xcortree=1873 /SigmaFactorBS="aacgggtgattctaaaaaggtaagtaaaaatatcatcgttat caatggtAAAGTGTATAATACGAGTGAacatagagaacatataaaaactgatttctca a" /listShort="yxxD, yxxE, S1514, S1513, bglP, bglH" /listLong="yxiE" /label="upshifts" CDS complement(3655768..3656037) /gene="yxiC" /locus_tag="BSU_39310" /old_locus_tag="BSU39310" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391810.1" /db_xref="EnsemblGenomes-Gn:BSU39310" /db_xref="EnsemblGenomes-Tr:CAB15967" /db_xref="InterPro:IPR020315" /db_xref="SubtiList:BG11132" /db_xref="UniProtKB/Swiss-Prot:P42295" /translation="MAQEIKMVYDTVKQGLSQLKNSAELKSSLPGHLSGRNHLNVVKS IEQLNKDIKELTEAYASVLAKHIAQTESAVNAMKETDENISSSMK*" /label="yxiC CDS" gene complement(3655768..3656037) /gene="yxiC" /locus_tag="BSU_39310" /old_locus_tag="BSU39310" /label="yxiC gene" CDS complement(3656049..3656414) /gene="yxiB" /locus_tag="BSU_39320" /old_locus_tag="BSU39320" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391811.1" /db_xref="EnsemblGenomes-Gn:BSU39320" /db_xref="EnsemblGenomes-Tr:CAB15968" /db_xref="InterPro:IPR031681" /db_xref="SubtiList:BG11131" /db_xref="UniProtKB/Swiss-Prot:P42294" /translation="MHSEMLLHSVKADLHEKQEQIHQLKRVLHEIRQIKHDFSEAQHL IHRPHLNREAWRGTHAERFEDIREGMNKAYQQIKSDQVSGIIESIEGKIHSLEGDVYS IRRQITRIEHEIEKEKHKK*" /label="yxiB CDS" gene complement(3656049..3656414) /gene="yxiB" /locus_tag="BSU_39320" /old_locus_tag="BSU39320" /label="yxiB gene" S_feature complement(3656415..3656480) /Source="Nicolas_S_feature" /locus_tag="new_4039160_4039225_c" /HighExp="T-1.40H, T-3.40H, T2.30H, T-2.40H, T-0.40H, T1.0H, T-1.10H, T-5.40H, T3.30H, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1515" promotor_-10 complement(3656467..3656486) /Source="Nicolas_upshift_promotors" /id="U3102" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.694305694305694" /psig="0.997002997002997" /xcortree=2983 /SigmaFactorBS="ccagttctatacctctcaagacaatcctttttacctATTTat ccaatatgacccATCATGTAATATGAAAATAGtctgtattgtaaagaatttacacagt t" /listShort="S1515, yxiB, yxiC, yxiD, yxxD, yxxE, S1514, S1513, bglP, bglH, yxiE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3656480) /Source="Nicolas_upshifts" /id="U3102" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.694305694305694" /psig="0.997002997002997" /xcortree=2983 /SigmaFactorBS="ccagttctatacctctcaagacaatcctttttacctATTTat ccaatatgacccATCATGTAATATGAAAATAGtctgtattgtaaagaatttacacagt t" /listShort="S1515, yxiB, yxiC, yxiD, yxxD, yxxE, S1514, S1513, bglP, bglH, yxiE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3656501..3656504) /Source="Nicolas_upshift_promotors" /id="U3102" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.694305694305694" /psig="0.997002997002997" /xcortree=2983 /SigmaFactorBS="ccagttctatacctctcaagacaatcctttttacctATTTat ccaatatgacccATCATGTAATATGAAAATAGtctgtattgtaaagaatttacacagt t" /listShort="S1515, yxiB, yxiC, yxiD, yxxD, yxxE, S1514, S1513, bglP, bglH, yxiE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3656721..3658130) /gene="abnB" /locus_tag="BSU_39330" /old_locus_tag="BSU39330" /EC_number="3.2.1.99" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14973026, 18408032, 18607095, 20883454" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14973026, 18408032, 18607095, 20883454; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arabinan endo-1,5-alpha-L-arabinosidase ([Ca(2+)-dependent]" /protein_id="NP_391812.2" /db_xref="EnsemblGenomes-Gn:BSU39330" /db_xref="EnsemblGenomes-Tr:CAB15969" /db_xref="GOA:P42293" /db_xref="InterPro:IPR006710" /db_xref="InterPro:IPR023296" /db_xref="InterPro:IPR032291" /db_xref="PDB:2X8F" /db_xref="PDB:2X8S" /db_xref="PDB:2X8T" /db_xref="PDB:4COT" /db_xref="SubtiList:BG11130" /db_xref="UniProtKB/Swiss-Prot:P42293" /translation="MFNRLFRVCFLAALIMAFTLPNSVYAQKPIFKEVSVHDPSIIET NGTFYVFGSHLASAKSNDLMQWQQLTTSVSNDNPLIPNVYEELKETFEWAQSDTLWAA DVTQLADGKYYMYYNACRGDSPRSAMGVAVADNIEGPYKNKGIFLKSGMEGTSSDGTP YDATKHPNVVDPHTFFDKDGKLWMVYGSYSGGIFILEMNPKTGFPLPGQGYGKKLLGG NHSRIEGPYVLYNPDTQYYYLYLSYGGLDATGGYNIRVARSKKPDGPYYDAEGNPMLD VRGKGGTFFDDRSIEPYGVKLMGSYTFETENEKGTGYVSPGHNSAYYDEKTGRSYLIF HTRFPGRGEEHEVRVHQLFMNKDGWPVAAPYRYAGETLKEVKQKDITGTYKLIQHGKD ISADIKQTINIQLNKNHTISGEMTGTWRKTGKNTADITLAGKKYNGVFLRQWDSVREK NVMTFSVLNTSGEAVWGSK*" /label="abnB CDS" gene complement(3656721..3658130) /gene="abnB" /locus_tag="BSU_39330" /old_locus_tag="BSU39330" /label="abnB gene" downshifts complement(3656744) /Source="Nicolas_upshifts" /id="D2041" /incds=0 /nref=2 /ntot=38 /MaxReadThrough="0.825980000000001" /MaxDrop="3.49689" /score="16.962389" /energy="-7.9" /TU="NA" /idTUdmin="U3101" /TUdmin="-7194" /isTUend="FALSE" /label="downshifts" S_feature complement(3658131..3658240) /Source="Nicolas_S_feature" /locus_tag="new_4040876_4040985_c" /HighExp="S2, T2.30H, BC, T2.0H, M9-stat, T3.0H, T3.30H, T4.0H, S1, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1516" CDS complement(3658264..3658428) /gene="yxzL" /locus_tag="BSU_39339" /old_locus_tag="BSU39339" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097797.1" /db_xref="EnsemblGenomes-Gn:BSU39339" /db_xref="EnsemblGenomes-Tr:CAX52712" /db_xref="UniProtKB/Swiss-Prot:C0H3T6" /translation="MAVSQLMQNLTKQLLHVRERKTDVMQEGETAKELNYEGEDMQAT SSAQNRQTSV*" /label="yxzL CDS" gene complement(3658264..3658428) /gene="yxzL" /locus_tag="BSU_39339" /old_locus_tag="BSU39339" /label="yxzL gene" promotor_-10 complement(3658313..3658331) /Source="Nicolas_upshift_promotors" /id="U3103" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=497 /SigmaFactorBS="tattacatgtacgcgaaagaaaaacagacgtgatgcaaGAAG GAGAAacagcaaaagAGTTGAACTATGAAGGAGAggatatgcaagcaacaagttctgc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3658328) /Source="Nicolas_upshifts" /id="U3103" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=497 /SigmaFactorBS="tattacatgtacgcgaaagaaaaacagacgtgatgcaaGAAG GAGAAacagcaaaagAGTTGAACTATGAAGGAGAggatatgcaagcaacaagttctgc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3658342..3658350) /Source="Nicolas_upshift_promotors" /id="U3103" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=497 /SigmaFactorBS="tattacatgtacgcgaaagaaaaacagacgtgatgcaaGAAG GAGAAacagcaaaagAGTTGAACTATGAAGGAGAggatatgcaagcaacaagttctgc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3658620..3658639) /Source="Nicolas_upshift_promotors" /id="U3104" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.440559440559441" /psig=1 /xcortree=2012 /SigmaFactorBS="attaattggttcagcagcagaagtcaaaaggttttttTATAG TCTttaacaagttagATTGCTATTGTAATAGCGTGacgcagaaagcagaacaggtttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3658636) /Source="Nicolas_upshifts" /id="U3104" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.440559440559441" /psig=1 /xcortree=2012 /SigmaFactorBS="attaattggttcagcagcagaagtcaaaaggttttttTATAG TCTttaacaagttagATTGCTATTGTAATAGCGTGacgcagaaagcagaacaggtttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3658652..3658659) /Source="Nicolas_upshift_promotors" /id="U3104" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.440559440559441" /psig=1 /xcortree=2012 /SigmaFactorBS="attaattggttcagcagcagaagtcaaaaggttttttTATAG TCTttaacaagttagATTGCTATTGTAATAGCGTGacgcagaaagcagaacaggtttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3658668..3658675 /Source="Nicolas_upshift_promotors" /id="U3105" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=495 /SigmaFactorBS="tagcaatctaacttgttaaagactataaaaaaaccTTTTGAC TtctgctgctgaaccAATTAATATAATACTCAGTTaatagttatcagaatttttagga a" /listShort="hutP, hutH, hutU, hutI, hutG, S1517, hutM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3658690..3658709 /Source="Nicolas_upshift_promotors" /id="U3105" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=495 /SigmaFactorBS="tagcaatctaacttgttaaagactataaaaaaaccTTTTGAC TtctgctgctgaaccAATTAATATAATACTCAGTTaatagttatcagaatttttagga a" /listShort="hutP, hutH, hutU, hutI, hutG, S1517, hutM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3658693 /Source="Nicolas_upshifts" /id="U3105" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=495 /SigmaFactorBS="tagcaatctaacttgttaaagactataaaaaaaccTTTTGAC TtctgctgctgaaccAATTAATATAATACTCAGTTaatagttatcagaatttttagga a" /listShort="hutP, hutH, hutU, hutI, hutG, S1517, hutM" /GFF_Attribute="listLong" /label="upshifts" CDS 3658747..3659193 /gene="hutP" /locus_tag="BSU_39340" /old_locus_tag="BSU39340" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15758992, 16192572, 16427271, 17395359, 18445631, 23748184, 24650662" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15758992, 16192572, 16427271, 17395359, 18445631, 23748184, 24650662; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional antiterminator" /protein_id="NP_391813.2" /db_xref="EnsemblGenomes-Gn:BSU39340" /db_xref="EnsemblGenomes-Tr:CAB15970" /db_xref="GOA:P10943" /db_xref="InterPro:IPR015111" /db_xref="InterPro:IPR023552" /db_xref="InterPro:IPR036482" /db_xref="PDB:1VEA" /db_xref="PDB:1WMQ" /db_xref="PDB:1WPS" /db_xref="PDB:1WPT" /db_xref="PDB:1WPU" /db_xref="PDB:1WPV" /db_xref="PDB:1WRN" /db_xref="PDB:1WRO" /db_xref="PDB:1WRQ" /db_xref="PDB:3BOY" /db_xref="PDB:4H4L" /db_xref="SubtiList:BG10666" /db_xref="UniProtKB/Swiss-Prot:P10943" /translation="MTLHKERRIGRLSVLLLLNEAEESTQVEELERDGWKVCLGKVGS MDAHKVVAAIETASKKSGVIQSEGYRESHALYHATMEALHGVTRGEMLLGSLLRTVGL RFAVLRGNPYESEAEGDWIAVSLYGTIGAPIKGLEHETFGVGINHI*" /label="hutP CDS" gene 3658747..3659193 /gene="hutP" /locus_tag="BSU_39340" /old_locus_tag="BSU39340" /label="hutP gene" downshifts 3659198 /Source="Nicolas_upshifts" /id="D2042" /incds=0 /nref=157 /ntot=226 /MaxReadThrough="6.10706" /MaxDrop="5.43744" /score="3.19376411" /energy="-17.8" /TU="U3105" /idTUdmin="U3105" /TUdmin="-7018" /isTUend="FALSE" /label="downshifts" CDS 3659306..3660832 /gene="hutH" /locus_tag="BSU_39350" /old_locus_tag="BSU39350" /EC_number="4.3.1.3" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9535092, 10220322, 17395359; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="histidine ammonia-lyase (histidase)" /protein_id="NP_391814.1" /db_xref="EnsemblGenomes-Gn:BSU39350" /db_xref="EnsemblGenomes-Tr:CAB15971" /db_xref="GOA:P10944" /db_xref="InterPro:IPR001106" /db_xref="InterPro:IPR005921" /db_xref="InterPro:IPR008948" /db_xref="InterPro:IPR022313" /db_xref="InterPro:IPR024083" /db_xref="SubtiList:BG10667" /db_xref="UniProtKB/Swiss-Prot:P10944" /translation="MVTLDGSSLTTADVARVLFDFEEAAASEESMERVKKSRAAVERI VRDEKTIYGINTGFGKFSDVLIQKEDSAALQLNLILSHACGVGDPFPECVSRAMLLLR ANALLKGFSGVRAELIEQLLAFLNKRVHPVIPQQGSLGASGDLAPLSHLALALIGQGE VFFEGERMPAMTGLKKAGIQPVTLTSKEGLALINGTQAMTAMGVVAYIEAEKLAYQTE RIASLTIEGLQGIIDAFDEDIHLARGYQEQIDVAERIRFYLSDSGLTTSQGELRVQDA YSLRCIPQVHGATWQTLGYVKEKLEIEMNAATDNPLIFNDGDKVISGGNFHGQPIAFA MDFLKIAISELANIAERRIERLVNPQLNDLPPFLSPHPGLQSGAMIMQYAAASLVSEN KTLAHPASVDSIPSSANQEDHVSMGTIAARHAYQVIANTRRVIAIEAICALQAVEYRG IEHAASYTKQLFQEMRKVVPSIQQDRVFSYDIERLTDWLKKESLIPDHQNKELRGMNI *" /label="hutH CDS" gene 3659306..3660832 /gene="hutH" /locus_tag="BSU_39350" /old_locus_tag="BSU39350" /label="hutH gene" CDS 3660829..3662487 /gene="hutU" /locus_tag="BSU_39360" /old_locus_tag="BSU39360" /EC_number="4.2.1.49" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15313616, 17395359, 22933560; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="urocanase" /protein_id="NP_391815.1" /db_xref="EnsemblGenomes-Gn:BSU39360" /db_xref="EnsemblGenomes-Tr:CAB15972" /db_xref="GOA:P25503" /db_xref="InterPro:IPR023636" /db_xref="InterPro:IPR023637" /db_xref="InterPro:IPR035085" /db_xref="InterPro:IPR035400" /db_xref="InterPro:IPR035401" /db_xref="InterPro:IPR036190" /db_xref="PDB:2FKN" /db_xref="SubtiList:BG10668" /db_xref="UniProtKB/Swiss-Prot:P25503" /translation="MTDVKKSIRANRGTELECLGWEQEAVLRMLRNNLDPEVAEKPED LIVYGGIGKAARDWDAFHAIEHSLKTLKNDETLLVQSGKPVGMFRTHPQAPRVLLANS VLVPKWADWEHFHELEKKGLMMYGQMTAGSWIYIGSQGILQGTYETFAELARQHFGGS LKGTLTLTAGLGGMGGAQPLSVTMNEGVVIAVEVDEKRIDKRIETKYCDRKTASIEEA LAWAEEAKLAGKPLSIALLGNAAEVHHTLLNRGVKIDIVTDQTSAHDPLIGYVPEGYS LDEADRLRQDTPELYVRLAKQSMKKHVEAMLAFQQKGSIVFDYGNNIRQVAKDEGLEN AFDFPGFVPAYIRPLFCEGKGPFRWAALSGDPADIYRTDALLKELFPTNKALHRWIDM AQEKVTFQGLPSRICWLGYGERKKMGLAINELVRTGELKAPVVIGRDHLDCGSVASPN RETEAMKDGSDAVGDWAVLNALVNTAAGASWVSFHHGGGVGMGYSLHAGMVAVADGSE LADERLARVLTSDPGMGIIRHADAGYERAVEVAKEQDIIVPMQK*" /label="hutU CDS" gene 3660829..3662487 /gene="hutU" /locus_tag="BSU_39360" /old_locus_tag="BSU39360" /label="hutU gene" CDS 3662500..3663765 /gene="hutI" /locus_tag="BSU_39370" /old_locus_tag="BSU39370" /EC_number="3.5.2.7" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16990261, 17395359, 18296777" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16990261, 17395359, 18296777; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="imidazolone-5-propionate hydrolase" /protein_id="NP_391816.1" /db_xref="EnsemblGenomes-Gn:BSU39370" /db_xref="EnsemblGenomes-Tr:CAB15973" /db_xref="GOA:P42084" /db_xref="InterPro:IPR005920" /db_xref="InterPro:IPR006680" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR032466" /db_xref="PDB:2BB0" /db_xref="PDB:2G3F" /db_xref="SubtiList:BG11100" /db_xref="UniProtKB/Swiss-Prot:P42084" /translation="MPKQIDTILINIGQLLTMESSGPRAGKSMQDLHVIEDAVVGIHE QKIVFAGQKGAEAGYEADEIIDCSGRLVTPGLVDPHTHLVFGGSREKEMNLKLQGISY LDILAQGGGILSTVKDTRAASEEELLQKAHFHLQRMLSYGTTTAEVKSGYGLEKETEL KQLRVAKKLHESQPVDLVSTFMGAHAIPPEYQNDPDDFLDQMLSLLPEIKEQELASFA DIFTETGVFTVSQSRRYLQKAAEAGFGLKIHADEIDPLGGAELAGKLKAVSADHLVGT SDEGIKKLAEAGTIAVLLPGTTFYLGKSTYARARAMIDEGVCVSLATDFNPGSSPTEN IQLIMSIAALHLKMTAEEIWHAVTVNAAYAIGKGEEAGQLKAGRSADLVIWQAPNYMY IPYHYGVNHVHQVMKNGTIVVNREGAILG*" /label="hutI CDS" gene 3662500..3663765 /gene="hutI" /locus_tag="BSU_39370" /old_locus_tag="BSU39370" /label="hutI gene" CDS 3663758..3664717 /gene="hutG" /locus_tag="BSU_39380" /old_locus_tag="BSU39380" /EC_number="3.5.3.8" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 10931887, 15355972, 17395359; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="formiminoglutamate hydrolase" /protein_id="NP_391817.1" /db_xref="EnsemblGenomes-Gn:BSU39380" /db_xref="EnsemblGenomes-Tr:CAB15974" /db_xref="GOA:P42068" /db_xref="InterPro:IPR005923" /db_xref="InterPro:IPR006035" /db_xref="InterPro:IPR020855" /db_xref="InterPro:IPR023696" /db_xref="PDB:3M1R" /db_xref="SubtiList:BG11099" /db_xref="UniProtKB/Swiss-Prot:P42068" /translation="MDKYPFLREAGSSFKDRDVTKMSDLIATWDGQDIKGPALIGVPL SKSSISHSGASFAPGTIRQALKHSSAYSAELGEHVVSELLYDLGDIDIHVTDIVKSHH HIFQTMHALLSDHPDWVPLILGGDNSISYSTIKAIAQTKGTTAVIQFDAHHDVRNTED GGPTNGTPFRRLLDEEIIEGQHLIQLGIREFSNSQAYEAYAKKHNVNIHTMDMIREKG LIPTIKEILPVVQDKTDFIFISVDMDVLDQSHAPGCPAIGPGGLYTDELLEAVKYIAQ QPNVAGIEIVEVDPTLDFRDMTSRAAAHVLLHALKGMKLSPFK*" /label="hutG CDS" gene 3663758..3664717 /gene="hutG" /locus_tag="BSU_39380" /old_locus_tag="BSU39380" /label="hutG gene" S_feature 3664718..3664792 /Source="Nicolas_S_feature" /locus_tag="new_4047463_4047537" /HighExp="Sw, BC, T3.30H, T4.0H, T5.0H, T3.0H, T2.30H, S8, M9-stat, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1517" CDS 3664793..3666220 /gene="hutM" /locus_tag="BSU_39390" /old_locus_tag="BSU39390" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 7704263, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="histidine degradation metabolites permease" /protein_id="NP_391818.2" /db_xref="EnsemblGenomes-Gn:BSU39390" /db_xref="EnsemblGenomes-Tr:CAB15975" /db_xref="GOA:P42087" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG11101" /db_xref="UniProtKB/Swiss-Prot:P42087" /translation="MNLQENSSQQLKRTMKSRHLFMISLGGVIGTGLFLSTGYTLHQA GPGGTILAYVIGGLMMYLVMQCLGELSVAMPVTGSFQKYATTFIGPSTGFMVGIMYWI NWVVTVGSEFTASGILMQRWFPDSSVWMWSAIFAALLFICNAFSVKLFAETEFWFSSV KIVTIILFIILGGAAMFGLISLNGTADAPMLSNFTDHGGLFPNGFLAVFIAMISVSFA FSGTELIGVTAGESANPQKDIPRSIRNVAWRTVIFFIGAVFILSGLISWKDAGVIESP FVAVFAEIGIPYAADIMNFVILTALLSVANSGLYASTRMMWSLANENMISSRFKKVTS KGIPLNALMISMAVSCLSLVSSIVAPGTVYVVMVAIAGFAGVVVWMSIALSQLLFRKR FLKKGGDVKDLTFRTPLYPLMPIAALLLCSASCIGLAFDPNQRIALFCGVPCIILCYL IYHFKRNVTKAKKISQEEYPADHIL*" /label="hutM CDS" gene 3664793..3666220 /gene="hutM" /locus_tag="BSU_39390" /old_locus_tag="BSU39390" /label="hutM gene" downshifts 3666216 /Source="Nicolas_upshifts" /id="D2043" /incds=0 /nref=11 /ntot=31 /MaxReadThrough="0.7432" /MaxDrop="6.18816" /score="8.21347356" /energy="-11.7" /TU="NA" /idTUdmin="U3105" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3666264..3667565) /gene="pdp" /locus_tag="BSU_39400" /old_locus_tag="BSU39400" /EC_number="2.4.2.2" /EC_number="2.4.2.3" /EC_number="2.4.2.4" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8550462, 10074062, 11065368, 15530033, 16469506, 21707079" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8550462, 10074062, 11065368, 15530033, 16469506, 21707079; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="pyrimidine-nucleoside phosphorylase" /protein_id="NP_391819.2" /db_xref="EnsemblGenomes-Gn:BSU39400" /db_xref="EnsemblGenomes-Tr:CAB15976" /db_xref="GOA:P39142" /db_xref="InterPro:IPR000053" /db_xref="InterPro:IPR000312" /db_xref="InterPro:IPR013102" /db_xref="InterPro:IPR017459" /db_xref="InterPro:IPR017872" /db_xref="InterPro:IPR018090" /db_xref="InterPro:IPR035902" /db_xref="InterPro:IPR036320" /db_xref="InterPro:IPR036566" /db_xref="PDB:5EP8" /db_xref="SubtiList:BG10985" /db_xref="UniProtKB/Swiss-Prot:P39142" /translation="MRMVDIIIKKQNGKELTTEEIQFFVNGYTDGSIPDYQASALAMA IFFQDMSDRERADLTMAMVNSGETIDLSAIEGIKVDKHSTGGVGDTTTLVLAPLVAAL DVPVAKMSGRGLGHTGGTIDKLEAIMGFHVELTKDEFIKLVNRDKVAVIGQSGNLTPA DKKLYALRDVTGTVNSIPLIASSIMSKKIAAGADAIVLDVKTGAGAFMKTEEDAAELA KAMVRIGNNVGRQTMAVISDMSQPLGFAIGNALEVKEAIDTLKGEGPEDLHELVLTLG SQMVVLAKKADTLDEARAKLEEVMKNGKALEKFKDFLKNQGGDSSIVDDPSKLPQAAY QIDVPAKEAGVVSEIVADEIGVAAMLLGAGRATKEDEIDLAVGIMLRKKVGDKVEKGE PLVTLYANRENVDEVIAKVYDNIRIAAEAKAPKLIHTLITE*" /label="pdp CDS" gene complement(3666264..3667565) /gene="pdp" /locus_tag="BSU_39400" /old_locus_tag="BSU39400" /label="pdp gene" downshifts complement(3666281) /Source="Nicolas_upshifts" /id="D2044" /incds=0 /nref=122 /ntot=224 /MaxReadThrough="1.27022" /MaxDrop="5.60021" /score="14.0361257" /energy="-13.1" /TU="NA" /idTUdmin="U3107" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" CDS complement(3667595..3668776) /gene="nupC" /locus_tag="BSU_39410" /old_locus_tag="BSU39410" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8550462, 11065368, 12591866, 15849754, 16850406, 25890046" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8550462, 11065368, 12591866, 15849754, 16850406, 25890046; Product type t : transporter" /codon_start=1 /transl_table=11 /product="pyrimidine-nucleoside Na+(H+) cotransporter" /protein_id="NP_391820.2" /db_xref="EnsemblGenomes-Gn:BSU39410" /db_xref="EnsemblGenomes-Tr:CAB15977" /db_xref="GOA:P39141" /db_xref="InterPro:IPR002668" /db_xref="InterPro:IPR008276" /db_xref="InterPro:IPR011657" /db_xref="InterPro:IPR018270" /db_xref="SubtiList:BG10984" /db_xref="UniProtKB/Swiss-Prot:P39141" /translation="MKYLIGIIGLIVFLGLAWIASSGKKRIKIRPIVVMLILQFILGY ILLNTGIGNFLVGGFAKGFGYLLEYAAEGINFVFGGLVNADQTTFFMNVLLPIVFISA LIGILQKWKVLPFIIRYIGLALSKVNGMGRLESYNAVASAILGQSEVFISLKKELGLL NQQRLYTLCASAMSTVSMSIVGAYMTMLKPEYVVTALVLNLFGGFIIASIINPYEVAK EEDMLRVEEEEKQSFFEVLGEYILDGFKVAVVVAAMLIGFVAIIALINGIFNAVFGIS FQGILGYVFAPFAFLVGIPWNEAVNAGSIMATKMVSNEFVAMTSLTQNGFHFSGRTTA IVSVFLVSFANFSSIGIIAGAVKGLNEKQGNVVARFGLKLLYGATLVSFLSAAIVGLI Y*" /label="nupC CDS" gene complement(3667595..3668776) /gene="nupC" /locus_tag="BSU_39410" /old_locus_tag="BSU39410" /label="nupC gene" S_feature complement(3668777..3668856) /Source="Nicolas_S_feature" /locus_tag="new_4051522_4051601_c" /HighExp="G150, G135, Oxctl, G180, Mt0, M40t45, Lbtran, M0t90, M40t90, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1518" CDS complement(3668857..3669528) /gene="deoC" /locus_tag="BSU_39420" /old_locus_tag="BSU39420" /EC_number="4.1.2.4" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8550462, 10074062, 11065368, 27033207" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8550462, 10074062, 11065368, 27033207; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="deoxyribose-phosphate aldolase" /protein_id="NP_391821.2" /db_xref="EnsemblGenomes-Gn:BSU39420" /db_xref="EnsemblGenomes-Tr:CAB15978" /db_xref="GOA:P39121" /db_xref="InterPro:IPR002915" /db_xref="InterPro:IPR011343" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR028581" /db_xref="SubtiList:BG10983" /db_xref="UniProtKB/Swiss-Prot:P39121" /translation="MSLANIIDHTALKPHTQKADILKLIEEAKTYKFASVCVNPTWVE LAAKELKGTGVDVCTVIGFPLGANTTETKAFETKDAISKGATEVDMVINIAALKDKED DVVEADIRGVVEAVAGKALVKVIIETCLLTDEEKERACRLAVSAGADFVKTSTGFSTG GATKEDIALMRKTVGPDIGVKASGGVRTKEDVDTMVEAGASRIGASAGVSIVKGENAS GGDNY*" /label="deoC CDS" gene complement(3668857..3669528) /gene="deoC" /locus_tag="BSU_39420" /old_locus_tag="BSU39420" /label="deoC gene" promotor_-35 3669477..3669480 /Source="Nicolas_upshift_promotors" /id="U3106" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.343656343656344" /psig="0.972027972027972" /xcortree=1858 /SigmaFactorBS="tgtatgttttcgcttcttcaattagttttagaatgtccgctt TTTGtgtatgcggtttcaaAGCTGTATGATCAATTATGTtggctaatgacatccttcg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3669495 /Source="Nicolas_upshifts" /id="U3106" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.343656343656344" /psig="0.972027972027972" /xcortree=1858 /SigmaFactorBS="tgtatgttttcgcttcttcaattagttttagaatgtccgctt TTTGtgtatgcggtttcaaAGCTGTATGATCAATTATGTtggctaatgacatccttcg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3669496..3669515 /Source="Nicolas_upshift_promotors" /id="U3106" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.343656343656344" /psig="0.972027972027972" /xcortree=1858 /SigmaFactorBS="tgtatgttttcgcttcttcaattagttttagaatgtccgctt TTTGtgtatgcggtttcaaAGCTGTATGATCAATTATGTtggctaatgacatccttcg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(3669556..3669575) /Source="Nicolas_upshift_promotors" /id="U3107" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig=1 /xcortree=1555 /SigmaFactorBS="cgttcaaacctttcattgaacaaaatttcaattacCAATTTA CatatgttcaaaagTCGGTTATGCTAAAAAATATcttaacaaaaaaggaagtgtgcga a" /listShort="deoC, S1518, nupC, pdp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3669571) /Source="Nicolas_upshifts" /id="U3107" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig=1 /xcortree=1555 /SigmaFactorBS="cgttcaaacctttcattgaacaaaatttcaattacCAATTTA CatatgttcaaaagTCGGTTATGCTAAAAAATATcttaacaaaaaaggaagtgtgcga a" /listShort="deoC, S1518, nupC, pdp" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3669589..3669596) /Source="Nicolas_upshift_promotors" /id="U3107" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig=1 /xcortree=1555 /SigmaFactorBS="cgttcaaacctttcattgaacaaaatttcaattacCAATTTA CatatgttcaaaagTCGGTTATGCTAAAAAATATcttaacaaaaaaggaagtgtgcga a" /listShort="deoC, S1518, nupC, pdp" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3669634..3670575) /gene="deoR" /locus_tag="BSU_39430" /old_locus_tag="BSU39430" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8550462, 10074062, 10714997, 24863636" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8550462, 10074062, 10714997, 24863636; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of pyrmidine deoxyribonucleosides degradation (DeoR-dR5P)" /protein_id="NP_391822.1" /db_xref="EnsemblGenomes-Gn:BSU39430" /db_xref="EnsemblGenomes-Tr:CAB15979" /db_xref="GOA:P39140" /db_xref="InterPro:IPR007324" /db_xref="InterPro:IPR013324" /db_xref="PDB:4OQP" /db_xref="PDB:4OQQ" /db_xref="SubtiList:BG10982" /db_xref="UniProtKB/Swiss-Prot:P39140" /translation="MDREKQQLSIEAARLYYQSDYSQQQIAEQLNISRPTVSRLLQYA KEKGYVQIRVMDPFEDLDALGSILEEKYGLLEAHVVFSPTPDYAGITHDLSRYGAEYM HETVKDGDIVGVSWGTTMYQIAQNMQPKQVKGVEVVQLKGGISHSRVNTYSAETIQLF AEAFQTMPRYLPLPVVFDNADVKRMVEKDRHIERIIEMGKQANIALFTVGTVRDEALL FRLGYFNEEEKALLKKQAVGDICSRFFDAKGNICSSAINDRTIGVELQDLRLKERSIL VAGGSRKVSSIHGALTGKYANVLIIDQHTARALVNDL*" /label="deoR CDS" gene complement(3669634..3670575) /gene="deoR" /locus_tag="BSU_39430" /old_locus_tag="BSU39430" /label="deoR gene" promotor_-10 complement(3670620..3670639) /Source="Nicolas_upshift_promotors" /id="U3108" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.723276723276723" /psig="0.996003996003996" /xcortree=2323 /SigmaFactorBS="gagcgtttttcagtttcttagaaatcagGTGGatgaaagccg gcgccAGCCTGTATAATAAAAGCAAatcaaaagcagttttatcaggactgatccacag g" /listShort="deoR, deoC, S1518, nupC, pdp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3670626) /Source="Nicolas_upshifts" /id="U3108" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.723276723276723" /psig="0.996003996003996" /xcortree=2323 /SigmaFactorBS="gagcgtttttcagtttcttagaaatcagGTGGatgaaagccg gcgccAGCCTGTATAATAAAAGCAAatcaaaagcagttttatcaggactgatccacag g" /listShort="deoR, deoC, S1518, nupC, pdp" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3670628..3670708) /Source="Nicolas_S_feature" /locus_tag="new_4053373_4053453_c" /HighExp="Etha, Diami, Salt, MG 10, Gly, MG 60, G180, GM 60, G135, dia5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.55204399999999998" /TUshortSig="SigB" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1519" promotor_-35 complement(3670655..3670658) /Source="Nicolas_upshift_promotors" /id="U3108" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.723276723276723" /psig="0.996003996003996" /xcortree=2323 /SigmaFactorBS="gagcgtttttcagtttcttagaaatcagGTGGatgaaagccg gcgccAGCCTGTATAATAAAAGCAAatcaaaagcagttttatcaggactgatccacag g" /listShort="deoR, deoC, S1518, nupC, pdp" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3670709..3671536) /gene="yxxB" /locus_tag="BSU_39440" /old_locus_tag="BSU39440" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10746760, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_391823.2" /db_xref="EnsemblGenomes-Gn:BSU39440" /db_xref="EnsemblGenomes-Tr:CAB15980" /db_xref="GOA:P39139" /db_xref="InterPro:IPR009597" /db_xref="SubtiList:BG10981" /db_xref="UniProtKB/Swiss-Prot:P39139" /translation="MAVKDRYMSKIKQETKPWIKRFGRLGYFAFGGVFILLGVLAFMT AAGAGRAKDSSGALQTLSRMPYGSLLLFFIGIGLIGYVIWMVLSAIKDTEGHGNSRRG LSRRIGNFFSAAVYTSIAWNALRFVFGQGDGGTSEQTWSAYVLAQPFGQWLTGLTGAG FIVFAIVQFMKGVRAAFMKEFDTSKMNKQMICITKNTGRAGNIARAIIFSAIGYFLIK TAMTADPDDTRGFDGALAELAQQPHGKLILSILALGLILYGMYAIMKGIYQHMTWEK* " /label="yxxB CDS" gene complement(3670709..3671536) /gene="yxxB" /locus_tag="BSU_39440" /old_locus_tag="BSU39440" /label="yxxB gene" downshifts complement(3671508) /Source="Nicolas_upshifts" /id="D2045" /incds=0 /nref=6 /ntot=96 /MaxReadThrough="4.46865" /MaxDrop="3.48502" /score="14.6805498" /energy="-16" /TU="U3109,U3111" /idTUdmin="U3111" /TUdmin="-770" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3671561..3671579) /Source="Nicolas_upshift_promotors" /id="U3109" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=169 /SigmaFactorBS="aacgtatctcagccagccatagctgaggcaggagcTGTTTCA actttgttcaatcGGGAATGTTACAGTAAAGAtttctgtgaaagagggttggacacat g" /listShort="yxxB, S1519, deoR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3671574) /Source="Nicolas_upshifts" /id="U3109" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=169 /SigmaFactorBS="aacgtatctcagccagccatagctgaggcaggagcTGTTTCA actttgttcaatcGGGAATGTTACAGTAAAGAtttctgtgaaagagggttggacacat g" /listShort="yxxB, S1519, deoR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3671593..3671599) /Source="Nicolas_upshift_promotors" /id="U3109" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=169 /SigmaFactorBS="aacgtatctcagccagccatagctgaggcaggagcTGTTTCA actttgttcaatcGGGAATGTTACAGTAAAGAtttctgtgaaagagggttggacacat g" /listShort="yxxB, S1519, deoR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3671609..3672721) /gene="yxeR" /locus_tag="BSU_39450" /old_locus_tag="BSU39450" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 1860825, 10746760, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ethanolamine permease" /protein_id="NP_391824.1" /db_xref="EnsemblGenomes-Gn:BSU39450" /db_xref="EnsemblGenomes-Tr:CAB15981" /db_xref="GOA:P54957" /db_xref="InterPro:IPR007441" /db_xref="SubtiList:BG11894" /db_xref="UniProtKB/Swiss-Prot:P54957" /translation="MTVNDAVVFILAAFLLWGAADYCLGNRWGLGERFADGFKAMGPL ALSMIGIVSLAPVLAAILIPIVAPFYTAIGADPSSFANTILAIDMGGYALAGEMAKDP QAGLFSWVFLGTMMGPAIVFTIPVALGIIEKEDHPYFAKGILIGLCTVPIGCLIGGLC AGFDIGMIGKNLLIPSLLSAVIAFGLWRYTDRMIQLFHLFGKAVSMVAIIGLAAVSVE TMTGIVLIPGMENVETGIQTTGTIAIALAGAFPMTAFITKTFKKPLQALGKCLHLDET ATAGLVTSLAHHIPMLASLKDMTPRGKVINVAFAVSGAFVLGSHLGFVAGMKKEMAAA MIIGKLAGGVTAAAAAAWMTPAQSAKQQKRISASHS*" /label="yxeR CDS" gene complement(3671609..3672721) /gene="yxeR" /locus_tag="BSU_39450" /old_locus_tag="BSU39450" /label="yxeR gene" CDS complement(3672791..3674128) /gene="yxeQ" /locus_tag="BSU_39460" /old_locus_tag="BSU39460" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12193636, 16513748, 16885442; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative catabolic enzyme" /protein_id="NP_391825.2" /db_xref="EnsemblGenomes-Gn:BSU39460" /db_xref="EnsemblGenomes-Tr:CAB15982" /db_xref="GOA:P54956" /db_xref="InterPro:IPR005656" /db_xref="InterPro:IPR036148" /db_xref="SubtiList:BG11893" /db_xref="UniProtKB/Swiss-Prot:P54956" /translation="MSKQGLTAGLAEAVRTSQPEHSVDAIHEAKKGLLDFTAASFAGR EDKGIQKLLRLIEDEGGRPLVPVIGQGKKAAPLQSAMLNGFIAHALDFDDVHSDVRGH PSAVIVPALIASAARGHDERLLGAYVVGVEVMARLGESIGSRHYEKGWHNTGTLGAIA AACAVGYAEELTQEELEKAIGFAATQSAGMRVQFGTEMKPLHAGLAAQAGLLAVKLAQ SEFGGSRTALDGETGFFSLYGDVEKAQHTLLNDWGAPWRIVQPGLWFKIYPFCSAAHH AADAVRQLISEETISAANTERIEVIFPPGGDAALTERSPKAGEEGRFSVEYVIALALH GHGLTVEHFSSQPIPNGVQTTMGRIQRVYDNAIQPAPHAVPKGRFTIVRAYLSDGRIC EARVDCPKGAPGNELSEEDIIEKLTLTVPQEKARRIITAVEKADIKEFLAHIE*" /label="yxeQ CDS" gene complement(3672791..3674128) /gene="yxeQ" /locus_tag="BSU_39460" /old_locus_tag="BSU39460" /label="yxeQ gene" CDS complement(3674125..3675267) /gene="sndB" /locus_tag="BSU_39470" /old_locus_tag="BSU39470" /EC_number="3.5.-.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12193636, 16513748, 16885442, 23944997, 28032445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12193636, 16513748, 16885442, 23944997, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetyl-sulfur-metabolite deacetylase" /protein_id="NP_391826.2" /db_xref="EnsemblGenomes-Gn:BSU39470" /db_xref="EnsemblGenomes-Tr:CAB15983" /db_xref="GOA:P54955" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR017439" /db_xref="InterPro:IPR033846" /db_xref="InterPro:IPR036264" /db_xref="PDB:1YSJ" /db_xref="SubtiList:BG11892" /db_xref="UniProtKB/Swiss-Prot:P54955" /translation="MADKAFHTRLINMRRDLHEHPELSFQEVETTKKIRRWLEEEQIE ILDVPQLKTGVIAEIKGREDGPVIAIRADIDALPIQEQTNLPFASKVDGTMHACGHDF HTASIIGTAMLLNQRRAELKGTVRFIFQPAEEIAAGARKVLEAGVLNGVSAIFGMHNK PDLPVGTIGVKEGPLMASVDRFEIVIKGKGGHAGIPNNSIDPIAAAGQIISGLQSVVS RNISSLQNAVVSITRVQAGTSWNVIPDQAEMEGTVRTFQKEARQAVPEHMRRVAEGIA AGYGAQAEFKWFPYLPSVQNDGTFLNAASEAAARLGYQTVHAEQSPGGEDFALYQEKI PGFFVWMGTNGTEEWHHPAFTLDEEALTVASQYFAELAVIVLETIK*" /label="sndB CDS" gene complement(3674125..3675267) /gene="sndB" /locus_tag="BSU_39470" /old_locus_tag="BSU39470" /label="sndB gene" CDS complement(3675284..3676033) /gene="yxeO" /locus_tag="BSU_39480" /old_locus_tag="BSU39480" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12193636, 16513748, 16885442, 25875741; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_391827.1" /db_xref="EnsemblGenomes-Gn:BSU39480" /db_xref="EnsemblGenomes-Tr:CAB15984" /db_xref="GOA:P54954" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030679" /db_xref="SubtiList:BG11891" /db_xref="UniProtKB/Swiss-Prot:P54954" /translation="MITVKNIRKAFKDLVVLDGIDLEVKRGEVVAIIGPSGSGKSTLL RCLNLLERPDQGLIEIGEAKLNAEKFTRKEAHRLRQQTAMVFQNYNLFKNKTALQNIT EALIVAQHKPRDEAKRIGMEILKQVGLEHKADSYPITMSGGQQQRIGIARALAVNPHA ILLDEPTSALDPELVTGVLQVIKSIAEKQTTMIIVTHEMAFAKEVADQVIFMADGHII EQGTPEELFDHPKNERTKRFIKQVGEPAELI*" /label="yxeO CDS" gene complement(3675284..3676033) /gene="yxeO" /locus_tag="BSU_39480" /old_locus_tag="BSU39480" /label="yxeO gene" CDS complement(3676046..3676720) /gene="yxeN" /locus_tag="BSU_39490" /old_locus_tag="BSU39490" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12193636, 15849754, 16513748, 16850406, 16885442; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (permease)" /protein_id="NP_391828.1" /db_xref="EnsemblGenomes-Gn:BSU39490" /db_xref="EnsemblGenomes-Tr:CAB15985" /db_xref="GOA:P54953" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11890" /db_xref="UniProtKB/Swiss-Prot:P54953" /translation="MNTIDWEFMISAFPTLIQALPITLFMAIAAMIFAIIGGLILALI TKNKIPVLHQLSKLYISFFRGVPTLVQLFLIYYGLPQLFPEMSKMTALTAAIIGLSLK NAAYLAEIFRAALNSVDDGQLEACLSVGMTKFQAYRRIILPQAIRNAIPATGNTFIGL LKETSLAFTLGVMEMFAQGKMYASGNLKYFETYLAVAIVYWVLTIIYSILQDLFERAM SKPYRT*" /label="yxeN CDS" gene complement(3676046..3676720) /gene="yxeN" /locus_tag="BSU_39490" /old_locus_tag="BSU39490" /label="yxeN gene" CDS complement(3676743..3677537) /gene="yxeM" /locus_tag="BSU_39500" /old_locus_tag="BSU39500" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12193636, 16513748, 16885442; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative ABC transporter (binding lipoprotein)" /protein_id="NP_391829.1" /db_xref="EnsemblGenomes-Gn:BSU39500" /db_xref="EnsemblGenomes-Tr:CAB15986" /db_xref="GOA:P54952" /db_xref="InterPro:IPR001638" /db_xref="InterPro:IPR018313" /db_xref="SubtiList:BG11889" /db_xref="UniProtKB/Swiss-Prot:P54952" /translation="MKMKKWTVLVVAALLAVLSACGNGNSSSKEDDNVLHVGATGQSY PFAYKENGKLTGFDVEVMEAVAKKIDMKLDWKLLEFSGLMGELQTGKLDTISNQVAVT DERKETYNFTKPYAYAGTQIVVKKDNTDIKSVDDLKGKTVAAVLGSNHAKNLESKDPD KKINIKTYETQEGTLKDVAYGRVDAYVNSRTVLIAQIKKTGLPLKLAGDPIVYEQVAF PFAKDDAHDKLRKKVNKALDELRKDGTLKKLSEKYFNEDITVEQKH*" /label="yxeM CDS" gene complement(3676743..3677537) /gene="yxeM" /locus_tag="BSU_39500" /old_locus_tag="BSU39500" /label="yxeM gene" promotor_-35 3677109..3677118 /Source="Nicolas_upshift_promotors" /id="U3110" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1707 /SigmaFactorBS="gctttcaaggtttttcgcgtggtttgaaccgagaacggcTGC GACTGTCttgccttttaaaTCGTCTACTGATTTGAtgtctgtattgtcttttttgacg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3677130 /Source="Nicolas_upshifts" /id="U3110" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1707 /SigmaFactorBS="gctttcaaggtttttcgcgtggtttgaaccgagaacggcTGC GACTGTCttgccttttaaaTCGTCTACTGATTTGAtgtctgtattgtcttttttgacg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3677131..3677146 /Source="Nicolas_upshift_promotors" /id="U3110" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1707 /SigmaFactorBS="gctttcaaggtttttcgcgtggtttgaaccgagaacggcTGC GACTGTCttgccttttaaaTCGTCTACTGATTTGAtgtctgtattgtcttttttgacg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(3677562..3678059) /gene="snaB" /locus_tag="BSU_39510" /old_locus_tag="BSU39510" /EC_number="2.3.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12193636, 16513748, 16885442, 23944997, 28032445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12193636, 16513748, 16885442, 23944997, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sulfur-containing aminoacid acetyltransferase" /protein_id="NP_391830.2" /db_xref="EnsemblGenomes-Gn:BSU39510" /db_xref="EnsemblGenomes-Tr:CAB15987" /db_xref="GOA:P54951" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11888" /db_xref="UniProtKB/Swiss-Prot:P54951" /translation="MKPRYRLAVERDAEQLLELTLRAYEPIRKLGIRFAAAHADLDLV LKNIRENACYVMEEDGRIIATITLRMPWGKQPGPYGVPHIWWFAVDPDTGKKGIGTKL LQWLEETILRDTLKVPFVSLGTADKHPWLIEMYERKGYVRSGEQDLGKGHITVYMKKQ LRHDL*" /label="snaB CDS" gene complement(3677562..3678059) /gene="snaB" /locus_tag="BSU_39510" /old_locus_tag="BSU39510" /label="snaB gene" CDS complement(3678073..3679398) /gene="yxeK" /locus_tag="BSU_39520" /old_locus_tag="BSU39520" /EC_number="1.14.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8892809, 12193636, 15294834, 16513748, 16885442, 23944997; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="putative monooxygenase" /protein_id="NP_391831.1" /db_xref="EnsemblGenomes-Gn:BSU39520" /db_xref="EnsemblGenomes-Tr:CAB15988" /db_xref="GOA:P54950" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR016215" /db_xref="InterPro:IPR036661" /db_xref="SubtiList:BG11887" /db_xref="UniProtKB/Swiss-Prot:P54950" /translation="MTSKKKQIKLGVFLAGTGHHVASWRHPDAPSDASMNLDYFKELA KTAERGKLDMLFLADSLSIDSKSHPNVLTRFEPFTLLSALAQVTSKIGLTATASTTYS EPFHIARQFASLDHLSNGRAGWNVVTSSIESTALNFSGEKHLEHHLRYQRAEEFVEIV KGLWDSWEEDAFIRNKETGEFFDKEKMHELNHKGEYFSVRGPLNVSRTPQGQPVIIQA GSSGDGKALAAKTAEVIFTAQNHLESAQEFYQSIKEQAAEFGRDPEKIAIMPGIFPII ADTEEAAQAKYKELQDLIIPSVGLQILQNYLGGIDLSAYPLDGPLPKLDAEASNAVKS RFKLVQEMAERDNMTIRELYKYVAGSRGHHIFVGTPEQLADKMQEWVDTKACDGFNIM PPLLPEGIEVFVDQVVPILQERGVFRKEYEGTTLREHFGLEKPVNRYAK*" /label="yxeK CDS" gene complement(3678073..3679398) /gene="yxeK" /locus_tag="BSU_39520" /old_locus_tag="BSU39520" /label="yxeK gene" promotor_-10 complement(3679475..3679494) /Source="Nicolas_upshift_promotors" /id="U3111" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.64035964035964" /psig=1 /xcortree=1742 /SigmaFactorBS="aatagaaaaaattaatcttaactcATTGACAAacgtccaaga caaAGGTACATTTTGATTTATTCatattaaacgactaggaatataggagtttattttt c" /listShort="yxeK, yxeL, yxeM, yxeN, yxeO, yxeP, yxeQ, yxeR, yxxB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3679479) /Source="Nicolas_upshifts" /id="U3111" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.64035964035964" /psig=1 /xcortree=1742 /SigmaFactorBS="aatagaaaaaattaatcttaactcATTGACAAacgtccaaga caaAGGTACATTTTGATTTATTCatattaaacgactaggaatataggagtttattttt c" /listShort="yxeK, yxeL, yxeM, yxeN, yxeO, yxeP, yxeQ, yxeR, yxxB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3679508..3679515) /Source="Nicolas_upshift_promotors" /id="U3111" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.64035964035964" /psig=1 /xcortree=1742 /SigmaFactorBS="aatagaaaaaattaatcttaactcATTGACAAacgtccaaga caaAGGTACATTTTGATTTATTCatattaaacgactaggaatataggagtttattttt c" /listShort="yxeK, yxeL, yxeM, yxeN, yxeO, yxeP, yxeQ, yxeR, yxxB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3679584..3679811) /gene="yxeJ" /locus_tag="BSU_39530" /old_locus_tag="BSU39530" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_391832.2" /db_xref="EnsemblGenomes-Gn:BSU39530" /db_xref="EnsemblGenomes-Tr:CAB15989" /db_xref="SubtiList:BG11886" /db_xref="UniProtKB/Swiss-Prot:P54949" /translation="MSLINSHQSADSGLNIWSQLFFYTIVTASEWIGGLQKRRKGKGN GEILYEIIGRKLSLCFIRLSFLADIEVALVE*" /label="yxeJ CDS" gene complement(3679584..3679811) /gene="yxeJ" /locus_tag="BSU_39530" /old_locus_tag="BSU39530" /label="yxeJ gene" CDS complement(3679798..3680784) /gene="yxeI" /locus_tag="BSU_39540" /old_locus_tag="BSU39540" /EC_number="3.5.1.11" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15937167, 16511127, 18667582, 21978958" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15937167, 16511127, 18667582, 21978958; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="penicillin V amidase" /protein_id="NP_391833.2" /db_xref="EnsemblGenomes-Gn:BSU39540" /db_xref="EnsemblGenomes-Tr:CAB15990" /db_xref="GOA:P54948" /db_xref="InterPro:IPR029055" /db_xref="InterPro:IPR029132" /db_xref="PDB:2OQC" /db_xref="SubtiList:BG11885" /db_xref="UniProtKB/Swiss-Prot:P54948" /translation="MCTSLTLETADRKHVLARTMDFAFQLGTEVILYPRRYSWNSEAD GRAHQTQYAFIGMGRKLGNILFADGINESGLSCAALYFPGYAEYEKTIREDTVHIVPH EFVTWVLSVCQSLEDVKEKIRSLTIVEKKLDLLDTVLPLHWILSDRTGRNLTIEPRAD GLKVYDNQPGVMTNSPDFIWHVTNLQQYTGIRPKQLESKEMGGLALSAFGQGLGTVGL PGDYTPPSRFVRAVYLKEHLEPAADETKGVTAAFQILANMTIPKGAVITEEDEIHYTQ YTSVMCNETGNYYFHHYDNRQIQKVNLFHEDLDCLEPKVFSAKAEESIHELN*" /label="yxeI CDS" gene complement(3679798..3680784) /gene="yxeI" /locus_tag="BSU_39540" /old_locus_tag="BSU39540" /label="yxeI gene" downshifts complement(3679802) /Source="Nicolas_upshifts" /id="D2046" /incds=0 /nref=7 /ntot=52 /MaxReadThrough="2.95669" /MaxDrop="3.32309" /score="23.0334771" /energy="-17.9" /TU="NA" /idTUdmin="U3113" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 3679935..3679944 /Source="Nicolas_upshift_promotors" /id="U3112" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=1238 /SigmaFactorBS="agtggtggaaatagtagtttccagtttCGTTGCACATcacgg aagtatatTGCGTATAATGAATTTCGTCttcttccgttatcactgcgccctttggtat c" /listShort="S1520" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3679958..3679977 /Source="Nicolas_upshift_promotors" /id="U3112" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=1238 /SigmaFactorBS="agtggtggaaatagtagtttccagtttCGTTGCACATcacgg aagtatatTGCGTATAATGAATTTCGTCttcttccgttatcactgcgccctttggtat c" /listShort="S1520" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3679968..3680601 /Source="Nicolas_S_feature" /locus_tag="new_4062713_4063346" /HighExp="S6, S7, S8, S5, Paraq, G150, H2O2, G180, LBGexp, Oxctl" /AntisenseName="yxeI" /AntisenseCor="0.24221971906572701" /AntisenseRegPval="-4.2" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.98" /TUlongSig="NA" /TUlongPSig="NA" /label="S1520" upshifts 3679968 /Source="Nicolas_upshifts" /id="U3112" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=1238 /SigmaFactorBS="agtggtggaaatagtagtttccagtttCGTTGCACATcacgg aagtatatTGCGTATAATGAATTTCGTCttcttccgttatcactgcgccctttggtat c" /listShort="S1520" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3680839..3680858) /Source="Nicolas_upshift_promotors" /id="U3113" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.997002997002997" /psig="0.999000999001" /xcortree=629 /SigmaFactorBS="ttttttcgttttatttgatgtaatgtcaatTCTTTGACgaat cgatttgactTTCGTTATGCTGATAAAACCaattcgttcacaatatgtatgatattaa t" /listShort="yxeI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3680850) /Source="Nicolas_upshifts" /id="U3113" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.997002997002997" /psig="0.999000999001" /xcortree=629 /SigmaFactorBS="ttttttcgttttatttgatgtaatgtcaatTCTTTGACgaat cgatttgactTTCGTTATGCTGATAAAACCaattcgttcacaatatgtatgatattaa t" /listShort="yxeI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3680873..3680880) /Source="Nicolas_upshift_promotors" /id="U3113" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.997002997002997" /psig="0.999000999001" /xcortree=629 /SigmaFactorBS="ttttttcgttttatttgatgtaatgtcaatTCTTTGACgaat cgatttgactTTCGTTATGCTGATAAAACCaattcgttcacaatatgtatgatattaa t" /listShort="yxeI" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3680939..3681751) /gene="hadM" /locus_tag="BSU_39550" /old_locus_tag="BSU39550" /EC_number="3.1.3.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 21575135, 23582330, 25527541, 25848029, 27435445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sugar-phosphate hydrolase (promiscuous)" /protein_id="NP_391834.1" /db_xref="EnsemblGenomes-Gn:BSU39550" /db_xref="EnsemblGenomes-Tr:CAB15991" /db_xref="GOA:P54947" /db_xref="InterPro:IPR000150" /db_xref="InterPro:IPR006379" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG11884" /db_xref="UniProtKB/Swiss-Prot:P54947" /translation="MYKLIAIDMDGTLLNDHHEVTEEVRDALHAAKAEGVKIVLCTGR PIGGVQRYLDELNLIEEGDYVIAYNGALVQNTHTNEVVSELSLGYDDLTSLYDLSLEL KTPMHFFDSSNLYTPNRDISEFTVYESYVTQVPLHFRKIDEVPKDILIPKVMFIDKPE NLSRVITSIPKDVREKYTMVRSAPFFYEILHSEASKGNAVRQLAQLLGIEQAEVMCIG DNGNDLTMIEWAGCGVAMANAIPEVLEAANFQTRSNNEHGVAHAIHELVLAK*" /label="hadM CDS" gene complement(3680939..3681751) /gene="hadM" /locus_tag="BSU_39550" /old_locus_tag="BSU39550" /label="hadM gene" promotor_-10 complement(3681781..3681800) /Source="Nicolas_upshift_promotors" /id="U3114" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.853146853146853" /psig="0.998001998001998" /xcortree=2354 /SigmaFactorBS="aagggcggcgtctaaacagaatccggagaaaaccatctcttc CGGTTGAAtatcaaaaagaaaaAACGATATGATGGGACTATAgcctgaaaacgacatg a" /listShort="yxeH" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(3681791..3682348) /gene="yxeG" /locus_tag="BSU_39560" /old_locus_tag="BSU39560" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein of unknown function" /protein_id="NP_391835.1" /db_xref="EnsemblGenomes-Gn:BSU39560" /db_xref="EnsemblGenomes-Tr:CAB15992" /db_xref="GOA:P54946" /db_xref="SubtiList:BG11883" /db_xref="UniProtKB/Swiss-Prot:P54946" /translation="MRNQKAERLVAAGLVLHIIQWIFILWAFLKVKHLFSDYTIYNPN VISGSMQSLSFIQMMRAMMYSGAIVNYVLFFALVLLIYGIVLHAILIVLEMAAYVMIR RNPSSSWGFFFIAAGVKLAILNITGIPFLAAGFLLMKQKKAENGVKAERKRKPRLRIR RQGRRLNRIRRKPSLPVEYQKEKTI*" /label="yxeG CDS" gene complement(3681791..3682348) /gene="yxeG" /locus_tag="BSU_39560" /old_locus_tag="BSU39560" /label="yxeG gene" upshifts complement(3681804) /Source="Nicolas_upshifts" /id="U3114" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.853146853146853" /psig="0.998001998001998" /xcortree=2354 /SigmaFactorBS="aagggcggcgtctaaacagaatccggagaaaaccatctcttc CGGTTGAAtatcaaaaagaaaaAACGATATGATGGGACTATAgcctgaaaacgacatg a" /listShort="yxeH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3681815..3681822) /Source="Nicolas_upshift_promotors" /id="U3114" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.853146853146853" /psig="0.998001998001998" /xcortree=2354 /SigmaFactorBS="aagggcggcgtctaaacagaatccggagaaaaccatctcttc CGGTTGAAtatcaaaaagaaaaAACGATATGATGGGACTATAgcctgaaaacgacatg a" /listShort="yxeH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3682329..3682763) /gene="yxeF" /locus_tag="BSU_39570" /old_locus_tag="BSU39570" /function="18: Unknown function" /experiment="publication(s) with functional evidences, PMID:11160890, 22693626" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11160890, 22693626; Product type s: structure" /codon_start=1 /transl_table=11 /product="lipocalin-like lipoprotein" /protein_id="NP_391836.1" /db_xref="EnsemblGenomes-Gn:BSU39570" /db_xref="EnsemblGenomes-Tr:CAB15993" /db_xref="InterPro:IPR012674" /db_xref="InterPro:IPR021664" /db_xref="PDB:2JOZ" /db_xref="SubtiList:BG11882" /db_xref="UniProtKB/Swiss-Prot:P54945" /translation="MVIPLRNKYGILFLIAVCIMVSGCQQQKEETPFYYGTWDEGRAP GPTDGVKSATVTFTEDEVVETEVMEGRGEVQLPFMAYKVISQSTDGSIEIQYLGPYYP LKSTLKRGENGTLIWEQNGQRKTMTRIESKTGREEKDEKSKS*" /label="yxeF CDS" gene complement(3682329..3682763) /gene="yxeF" /locus_tag="BSU_39570" /old_locus_tag="BSU39570" /label="yxeF gene" promotor_-35 3682788..3682797 /Source="Nicolas_upshift_promotors" /id="U3115" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1295 /SigmaFactorBS="ctcaaggggatcaccattctttcctccttttttgggcgaatG CCGTGCCACtgtgccaatgacTACATAAGTTATAAGGAATTcacccacaaggagactg a" /listShort="yxeE" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3682807 /Source="Nicolas_upshifts" /id="U3115" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1295 /SigmaFactorBS="ctcaaggggatcaccattctttcctccttttttgggcgaatG CCGTGCCACtgtgccaatgacTACATAAGTTATAAGGAATTcacccacaaggagactg a" /listShort="yxeE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3682810..3682829 /Source="Nicolas_upshift_promotors" /id="U3115" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1295 /SigmaFactorBS="ctcaaggggatcaccattctttcctccttttttgggcgaatG CCGTGCCACtgtgccaatgacTACATAAGTTATAAGGAATTcacccacaaggagactg a" /listShort="yxeE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3682823) /Source="Nicolas_upshifts" /id="U3116" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.995004995004995" /psig="0.004995004995005" /xcortree=689 /SigmaFactorBS="agctgagggctgtaatattgataagggTTCATgtgatcagTC TCCTTGTGGGTGAattccttataacttatgtagtcattggcacagtggcacggcattc g" /listShort="yxeF, yxeG, yxeH" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3682824..3683235) /Source="Nicolas_S_feature" /locus_tag="new_4065569_4065980_c" /HighExp="Salt, H2O2, Paraq, dia15, Oxctl, Diami, Cold, G150, Lbtran, LBGexp" /AntisenseName="yxeE" /AntisenseCor="-0.602938477548701" /AntisenseRegPval="-27.3" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.391, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1521" promotor_-10 complement(3682829..3682843) /Source="Nicolas_upshift_promotors" /id="U3116" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.995004995004995" /psig="0.004995004995005" /xcortree=689 /SigmaFactorBS="agctgagggctgtaatattgataagggTTCATgtgatcagTC TCCTTGTGGGTGAattccttataacttatgtagtcattggcacagtggcacggcattc g" /listShort="yxeF, yxeG, yxeH" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3682852..3682856) /Source="Nicolas_upshift_promotors" /id="U3116" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.995004995004995" /psig="0.004995004995005" /xcortree=689 /SigmaFactorBS="agctgagggctgtaatattgataagggTTCATgtgatcagTC TCCTTGTGGGTGAattccttataacttatgtagtcattggcacagtggcacggcattc g" /listShort="yxeF, yxeG, yxeH" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3682852..3683217 /gene="cotNE" /locus_tag="BSU_39580" /old_locus_tag="BSU39580" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10714992, 17905812, 19933362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10714992, 17905812, 19933362; Product type s: structure" /codon_start=1 /transl_table=11 /product="inner spore coat protein" /protein_id="NP_391837.1" /db_xref="EnsemblGenomes-Gn:BSU39580" /db_xref="EnsemblGenomes-Tr:CAB15994" /db_xref="SubtiList:BG11881" /db_xref="UniProtKB/Swiss-Prot:P54944" /translation="MNPYQYYSPQLPQQEPYYSHYEYNPYPQQDVYDPYQMDRQPALE RRIAALERQNEQQSRELTRLTNEDRRQNREIARIAEQVNQLSQAVERHTRRLNRLNQR LRTVENRLNIPFTAGEGGF*" /label="cotNE CDS" gene 3682852..3683217 /gene="cotNE" /locus_tag="BSU_39580" /old_locus_tag="BSU39580" /label="cotNE gene" downshifts 3683231 /Source="Nicolas_upshifts" /id="D2047" /incds=0 /nref=31 /ntot=47 /MaxReadThrough="1.46494" /MaxDrop="8.36553" /score="27.2157513" /energy="-12.2" /TU="U3115" /idTUdmin="U3115" /TUdmin="-38" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3683235..3683239) /Source="Nicolas_upshift_promotors" /id="U3117" /multdbtbs="-" /comp="M9" /sig="Sig-" /pcomp="0.390609390609391" /psig="0.390609390609391" /xcortree=290 /SigmaFactorBS="cgttttaacatataagaaatgcggaaaacgaaaccCtgagat gggagaatcgtattCCGCTttttttctttgtttcgctcagaaaccgccttcccctgca g" /listShort="S1521" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3683235) /Source="Nicolas_upshifts" /id="U3117" /multdbtbs="-" /comp="M9" /sig="Sig-" /pcomp="0.390609390609391" /psig="0.390609390609391" /xcortree=290 /SigmaFactorBS="cgttttaacatataagaaatgcggaaaacgaaaccCtgagat gggagaatcgtattCCGCTttttttctttgtttcgctcagaaaccgccttcccctgca g" /listShort="S1521" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3683237..3683323) /Source="Nicolas_S_feature" /locus_tag="new_4065982_4066068_c" /HighExp="Salt, S8, H2O2, dia15, S7, Paraq, Diami, aero, Oxctl, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1522" promotor_-10 complement(3683316..3683335) /Source="Nicolas_upshift_promotors" /id="U3118" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=2444 /SigmaFactorBS="ctacaattattttcctcagcccctctaTCTTTGAAtgaaaac ggtaaaGATTGTATACTGGGTACAAAccctttttatgtaaatgttccgttttaacata t" /listShort="S1522, S1521, yxeF, yxeG, yxeH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3683323) /Source="Nicolas_upshifts" /id="U3118" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=2444 /SigmaFactorBS="ctacaattattttcctcagcccctctaTCTTTGAAtgaaaac ggtaaaGATTGTATACTGGGTACAAAccctttttatgtaaatgttccgttttaacata t" /listShort="S1522, S1521, yxeF, yxeG, yxeH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3683349..3683356) /Source="Nicolas_upshift_promotors" /id="U3118" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=2444 /SigmaFactorBS="ctacaattattttcctcagcccctctaTCTTTGAAtgaaaac ggtaaaGATTGTATACTGGGTACAAAccctttttatgtaaatgttccgttttaacata t" /listShort="S1522, S1521, yxeF, yxeG, yxeH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3683396..3683402 /Source="Nicolas_upshift_promotors" /id="U3119" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.97002997002997" /psig="0.97002997002997" /xcortree=861 /SigmaFactorBS="ggctgaggaaaataattgtagttcctctttgacGGAATTTct tttcattcaagTTGCATGATAATaccgactcacgtcaatcgatacatggagggatcat t" /listShort="yxeD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3683416..3683427 /Source="Nicolas_upshift_promotors" /id="U3119" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.97002997002997" /psig="0.97002997002997" /xcortree=861 /SigmaFactorBS="ggctgaggaaaataattgtagttcctctttgacGGAATTTct tttcattcaagTTGCATGATAATaccgactcacgtcaatcgatacatggagggatcat t" /listShort="yxeD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3683423 /Source="Nicolas_upshifts" /id="U3119" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.97002997002997" /psig="0.97002997002997" /xcortree=861 /SigmaFactorBS="ggctgaggaaaataattgtagttcctctttgacGGAATTTct tttcattcaagTTGCATGATAATaccgactcacgtcaatcgatacatggagggatcat t" /listShort="yxeD" /GFF_Attribute="listLong" /label="upshifts" CDS 3683465..3683818 /gene="yxeD" /locus_tag="BSU_39590" /old_locus_tag="BSU39590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 26506528" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391838.2" /db_xref="EnsemblGenomes-Gn:BSU39590" /db_xref="EnsemblGenomes-Tr:CAB15995" /db_xref="SubtiList:BG11880" /db_xref="UniProtKB/Swiss-Prot:P54943" /translation="MHNTQHGLQQLNQCRQTAQQLIQQTQQSSQQYRQMLHQEQQNIQ MLQQILNHEQQAAHTIQQALHGHDMAIQKCQQVVNMCNQMQQELTGQSSVMNTNVSTL PFGQNTTFQQQSYQQ*" /label="yxeD CDS" gene 3683465..3683818 /gene="yxeD" /locus_tag="BSU_39590" /old_locus_tag="BSU39590" /label="yxeD gene" downshifts 3683813 /Source="Nicolas_upshifts" /id="D2048" /incds=0 /nref=24 /ntot=55 /MaxReadThrough="0.20641" /MaxDrop="6.88486" /score="27.2157513" /energy="-12.2" /TU="NA" /idTUdmin="U3119" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" CDS complement(3683862..3684260) /gene="yxeC" /locus_tag="BSU_39600" /old_locus_tag="BSU39600" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein of unknown function" /protein_id="NP_391839.2" /db_xref="EnsemblGenomes-Gn:BSU39600" /db_xref="EnsemblGenomes-Tr:CAB15996" /db_xref="GOA:P54942" /db_xref="SubtiList:BG11879" /db_xref="UniProtKB/Swiss-Prot:P54942" /translation="MGITKRGAAWEWLHSWWMLFIFMPFAITSFFAFLFIGIKVRNRK WIMYGIIYFFIFAFGFVLPDLPGVFIVVPLWAVTIIHGFKVRPLYLIQLDVYKDHVEA RAFAEARSEAESRFHAPKQSIQDIHIRKEQ*" /label="yxeC CDS" gene complement(3683862..3684260) /gene="yxeC" /locus_tag="BSU_39600" /old_locus_tag="BSU39600" /label="yxeC gene" downshifts complement(3683870) /Source="Nicolas_upshifts" /id="D2049" /incds=0 /nref=145 /ntot=243 /MaxReadThrough="1.70512" /MaxDrop="5.26494" /score="9.81431167" /energy="-12.2" /TU="NA" /idTUdmin="U3120" /TUdmin=3 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3684275..3684294) /Source="Nicolas_upshift_promotors" /id="U3120" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.602397602397602" /psig="0.999000999001" /xcortree=2316 /SigmaFactorBS="tatcactatttttaagggagaaagtttttcccgtttatgGGT GacgcggtgtgcctaATCGATTATTATAGGTAAATaggaggagaaaaatatgggaatt a" /listShort="yxeC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3684291) /Source="Nicolas_upshifts" /id="U3120" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.602397602397602" /psig="0.999000999001" /xcortree=2316 /SigmaFactorBS="tatcactatttttaagggagaaagtttttcccgtttatgGGT GacgcggtgtgcctaATCGATTATTATAGGTAAATaggaggagaaaaatatgggaatt a" /listShort="yxeC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3684309..3684312) /Source="Nicolas_upshift_promotors" /id="U3120" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.602397602397602" /psig="0.999000999001" /xcortree=2316 /SigmaFactorBS="tatcactatttttaagggagaaagtttttcccgtttatgGGT GacgcggtgtgcctaATCGATTATTATAGGTAAATaggaggagaaaaatatgggaatt a" /listShort="yxeC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3684348..3684355 /Source="Nicolas_upshift_promotors" /id="U3121" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.585414585414585" /psig=1 /xcortree=2105 /SigmaFactorBS="cgggaaaaactttctcccttaaaaatagtGATAGACGgagaa caggtttctTGCTATATTATTAATTGATAatgataatcattactaatctattgagata c" /listShort="yxeB, S1523" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3684364..3684382) /Source="Nicolas_upshift_promotors" /id="U3122" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=775 /SigmaFactorBS="atcaagaaccctcccactatgtatctcaatagattaGTAATG attatcattatcaatTAATAATATAGCAAGAAACctgttctccgtctatcactatttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 3684370..3684389 /Source="Nicolas_upshift_promotors" /id="U3121" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.585414585414585" /psig=1 /xcortree=2105 /SigmaFactorBS="cgggaaaaactttctcccttaaaaatagtGATAGACGgagaa caggtttctTGCTATATTATTAATTGATAatgataatcattactaatctattgagata c" /listShort="yxeB, S1523" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3684379 /Source="Nicolas_upshifts" /id="U3121" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.585414585414585" /psig=1 /xcortree=2105 /SigmaFactorBS="cgggaaaaactttctcccttaaaaatagtGATAGACGgagaa caggtttctTGCTATATTATTAATTGATAatgataatcattactaatctattgagata c" /listShort="yxeB, S1523" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3684379) /Source="Nicolas_upshifts" /id="U3122" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=775 /SigmaFactorBS="atcaagaaccctcccactatgtatctcaatagattaGTAATG attatcattatcaatTAATAATATAGCAAGAAACctgttctccgtctatcactatttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3684398..3684403) /Source="Nicolas_upshift_promotors" /id="U3122" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=775 /SigmaFactorBS="atcaagaaccctcccactatgtatctcaatagattaGTAATG attatcattatcaatTAATAATATAGCAAGAAACctgttctccgtctatcactatttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3684438..3685403 /gene="frxB" /locus_tag="BSU_39610" /old_locus_tag="BSU39610" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 12354229, 16672620, 8388528, 19254027, 23924612, 25007174; Product type t : transporter" /codon_start=1 /transl_table=11 /product="desferrioxamine-and ferrichrome-binding transporter lipoprotein (shuttle system)" /protein_id="NP_391840.2" /db_xref="EnsemblGenomes-Gn:BSU39610" /db_xref="EnsemblGenomes-Tr:CAB15997" /db_xref="GOA:P54941" /db_xref="InterPro:IPR002491" /db_xref="SubtiList:BG11878" /db_xref="UniProtKB/Swiss-Prot:P54941" /translation="MKKNILLVGMLVLLLMFVSACSGTASKGSSSDSASEKTEMRTYK SPKGNVNIPAHPKRIVTDFYAGELLSVGANVVGSGSWSFDNPFLKSKLKNVKDVGDPI SVEKVMELQPDLIVVMNEENVDKLKKIAPTVVIPYNTAKNVEDTVSMFGDIAGAKDQA KSFMADFNKKAEAAKKKIAGVIDKDATFGIYENTDKGEFWVFNDNGGRGGQAVYNALG LKAPEKIEQDVIKKGEMKQLSQEVIPEYAADYMFITDYNPKGESKTLDKLENSSIWKN LDAVKHNRVFINDFDSFYPYDPISVSKQVDIITDMLIKRAEENKK*" /label="frxB CDS" gene 3684438..3685403 /gene="frxB" /locus_tag="BSU_39610" /old_locus_tag="BSU39610" /label="frxB gene" upshifts 3684831 /Source="Nicolas_upshifts" /id="U3123" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.726273726273726" /psig="0.726273726273726" /xcortree=773 /SigmaFactorBS="cctgacttaattgttgtcatgaatgaagagaatgttgataaa ttaaagaaaatcgctccgactgttgTCATACCTTATAACACAGCgaaaaacgtagaag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 3684838..3684856 /Source="Nicolas_upshift_promotors" /id="U3123" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.726273726273726" /psig="0.726273726273726" /xcortree=773 /SigmaFactorBS="cctgacttaattgttgtcatgaatgaagagaatgttgataaa ttaaagaaaatcgctccgactgttgTCATACCTTATAACACAGCgaaaaacgtagaag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" downshifts 3685310 /Source="Nicolas_upshifts" /id="D2050" /incds=1 /nref=55 /ntot=191 /MaxReadThrough="6.103" /MaxDrop="4.3334" /score="22.3558496" /energy="-13.4" /TU="U3121" /idTUdmin="U3123" /TUdmin=193 /isTUend="FALSE" /label="downshifts" downshifts 3685381 /Source="Nicolas_upshifts" /id="D2051" /incds=0 /nref=1 /ntot=62 /MaxReadThrough="4.41732" /MaxDrop="3.7101" /score="22.3558496" /energy="-13.4" /TU="U3121" /idTUdmin="U3123" /TUdmin=264 /isTUend="FALSE" /label="downshifts" S_feature 3685426..3686222 /Source="Nicolas_S_feature" /locus_tag="new_4068171_4068967" /HighExp="H2O2, Paraq, Lbexp, dia0, LBGexp, G150, B36, dia15, B60, GM 25" /AntisenseName="yxeA" /AntisenseCor="0.20524492145617201" /AntisenseRegPval="-3.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1523" CDS complement(3685444..3685791) /gene="yxeA" /locus_tag="BSU_39620" /old_locus_tag="BSU39620" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391841.1" /db_xref="EnsemblGenomes-Gn:BSU39620" /db_xref="EnsemblGenomes-Tr:CAB15998" /db_xref="InterPro:IPR006542" /db_xref="InterPro:IPR036166" /db_xref="PDB:3NPP" /db_xref="SubtiList:BG11877" /db_xref="UniProtKB/Swiss-Prot:P54940" /translation="MKKAMAILAVLAAAAVICGLLFFHNDVTDRFNPFIHQQDVYVQI DRDGRHLSPGGTEYTLDGYNASGKKEEVTFFAGKELRKNAYLKVKAKGKYVETWEEVK FEDMPDSVQSKLK*" /label="yxeA CDS" gene complement(3685444..3685791) /gene="yxeA" /locus_tag="BSU_39620" /old_locus_tag="BSU39620" /label="yxeA gene" downshifts complement(3685457) /Source="Nicolas_upshifts" /id="D2052" /incds=0 /nref=2 /ntot=78 /MaxReadThrough="1.28842" /MaxDrop="2.99568" /score="38.5550476" /energy="-11.6" /TU="NA" /idTUdmin="U3120" /TUdmin="-1584" /isTUend="FALSE" /label="downshifts" CDS complement(3685805..3687673) /gene="tpeM" /locus_tag="BSU_39630" /old_locus_tag="BSU39630" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15289557, 15849754, 15870467, 16850406, 21078927, 28472044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15289557, 15849754, 15870467, 16850406, 21078927, 28472044; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (permease); efflux of cationic peptides" /protein_id="NP_391842.2" /db_xref="EnsemblGenomes-Gn:BSU39630" /db_xref="EnsemblGenomes-Tr:CAB15999" /db_xref="GOA:P42424" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR027022" /db_xref="SubtiList:BG11129" /db_xref="UniProtKB/Swiss-Prot:P42424" /translation="MTFLQFAYKNVTRNKRAYLAFFLSSAFSVLIFFTFAMFLFHPAL KEGYLNNIAKKGLTAAEWMIFVFSFLFVLYSVNAFLKSRNKEFGILLMQGITPGQLRK LITAENMIIGVMSIAAGIIGGFIFSKTFFTVGAYILEMDALPLYMPWKALGITACGFL LLFFFLSQFTILFVRSNTVIKLIKGTGKVKPEPKPSVLLSLFGIACLCGGYGMVLKGN VHGAEPFIILLLTVIGTYFFFSQSSIWILRALKKWKTFYLRGKNIIWVSDLVYRLKDN ARLFFIVSIISAVAFTATGVLAMYKSTVGAEESAYEMEYLSYSNNPKEQTHLKDIDHE LKTHGFTYTKDKIDVSYVRYQEGETVPPVYMISESDAAKYFHVKVNGLKEDEAVYFPG TYDRNFKNEAPDQLKLLNQKGELSDQKLSVKEVKKPLISLNAIIAVNDQTFDQLKSLG DKASLYGYSYDHWKDSLEISQSLQNEIYGNYIDVHSDFASKAGTYYDTVQLPSLSLFI GLFIAIVFFVAAASFLYFRLFTDLDEDRERYRSLAKIGLSEREMAQSVTIQLAILFFF PFVIAVMHTLFALRTLAVEGYSDVAGPLSLTIGGFFIFQLLFFLAVRSSYLKKMNK*" /label="tpeM CDS" gene complement(3685805..3687673) /gene="tpeM" /locus_tag="BSU_39630" /old_locus_tag="BSU39630" /label="tpeM gene" CDS complement(3687648..3688421) /gene="tpeL" /locus_tag="BSU_39640" /old_locus_tag="BSU39640" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15289557, 15870467, 17600057, 21078927, 28472044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15289557, 15870467, 17600057, 21078927, 28472044; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (ATP-binding protein); efflux ofcationic peptides" /protein_id="NP_391843.2" /db_xref="EnsemblGenomes-Gn:BSU39640" /db_xref="EnsemblGenomes-Tr:CAB16000" /db_xref="GOA:P42423" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11128" /db_xref="UniProtKB/Swiss-Prot:P42423" /translation="MANMLEVKHINKTYKGQVSYQALKQISFSIEEGEFTAVMGPSGS GKTTLLNIISTIDRPDSGDILINGENPHRLKRTKLAHFRRKQLGFVFQDFNLLDTLTI GENIMLPLTLEKEAPSVMEEKLHGIAAKLGIENLLNKRTFEVSGGQRQRAAIARAVIH KPSLILADEPTGNLDSKATKDVMETLQSLNRDDHVTALMVTHDPVSASYCRRVIFIKD GELFNEIYRGENRQVFYEQILDVLSMLGGNANDLSSVRL*" /label="tpeL CDS" gene complement(3687648..3688421) /gene="tpeL" /locus_tag="BSU_39640" /old_locus_tag="BSU39640" /label="tpeL gene" CDS complement(3688565..3689542) /gene="tpeK" /locus_tag="BSU_39650" /old_locus_tag="BSU39650" /EC_number="2.7.13.3" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 15289557, 15870467, 21283517, 25875741" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15289557, 15870467, 21283517, 25875741; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YxdJ]" /protein_id="NP_391844.1" /db_xref="EnsemblGenomes-Gn:BSU39650" /db_xref="EnsemblGenomes-Tr:CAB16001" /db_xref="GOA:P42422" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11127" /db_xref="UniProtKB/Swiss-Prot:P42422" /translation="MKLFLRSHAVLILLFLLQGLFVFFYYWFAGLHSFSHLFYILGVQ LLILAGYLAYRWYKDRGVYHWLSSGQEGTDIPYLGSSVFCSELYEKQMELIRLQHQKL HETEAKLDARVTYMNQWVHQVKTPLSVINLIIQEEDEPVFEQIKKEVRQIEFGLETLL YSSRLDLFERDFKIEAVSLSELLQSVIQSYKRFFIQYRVYPKMNVCDDHQIYTDAKWL KFAIGQVVTNAVKYSAGKSDRLELNVFCDEDRTVLEVKDYGVGIPSQDIKRVFDPYYT GENGRRFQESTGIGLHLVKEITDKLNHTVDISSSPGEGTSVRFSFLTKM*" /label="tpeK CDS" gene complement(3688565..3689542) /gene="tpeK" /locus_tag="BSU_39650" /old_locus_tag="BSU39650" /label="tpeK gene" CDS complement(3689539..3690228) /gene="tpeJ" /locus_tag="BSU_39660" /old_locus_tag="BSU39660" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 15289557, 15870467, 21283517, 25875741" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15289557, 15870467, 21283517, 25875741; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [TpeK(YxdK)]" /protein_id="NP_391845.1" /db_xref="EnsemblGenomes-Gn:BSU39660" /db_xref="EnsemblGenomes-Tr:CAB16002" /db_xref="GOA:P42421" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11126" /db_xref="UniProtKB/Swiss-Prot:P42421" /translation="MNKIMIVEDSEDIRGLLQNYLEKYGYQTVVAADFTAVLDVFLRE KPDVVLLDINLPAYDGYYWCRQIRQHSTSPIIFISARSGEMDQVMAIENGGDDYIEKP FSYDIVLAKIKSQIRRAYGEYAAKQGEKVVEYAGVQLFVERFELRFQDEKSELSKKES KLLEVLLERGEKVTSRDRLMEKTWDTDIFIDDNTLNVYITRLRKKLRELNAPVSIEAV RGEGYQLRAQS*" /label="tpeJ CDS" gene complement(3689539..3690228) /gene="tpeJ" /locus_tag="BSU_39660" /old_locus_tag="BSU39660" /label="tpeJ gene" promotor_-10 complement(3690255..3690274) /Source="Nicolas_upshift_promotors" /id="U3124" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.440559440559441" /psig="0.963036963036963" /xcortree=1786 /SigmaFactorBS="agaccagaaaccgccgagatggcggtttttttgtgcggTGTT GCGtccatacgcccaaaACGATTATGATGATGGCAGCagtgtaagaaacgggagtggt t" /listShort="yxdJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3690273) /Source="Nicolas_upshifts" /id="U3124" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.440559440559441" /psig="0.963036963036963" /xcortree=1786 /SigmaFactorBS="agaccagaaaccgccgagatggcggtttttttgtgcggTGTT GCGtccatacgcccaaaACGATTATGATGATGGCAGCagtgtaagaaacgggagtggt t" /listShort="yxdJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3690289..3690295) /Source="Nicolas_upshift_promotors" /id="U3124" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.440559440559441" /psig="0.963036963036963" /xcortree=1786 /SigmaFactorBS="agaccagaaaccgccgagatggcggtttttttgtgcggTGTT GCGtccatacgcccaaaACGATTATGATGATGGCAGCagtgtaagaaacgggagtggt t" /listShort="yxdJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3690336..3691208) /gene="iolJ" /locus_tag="BSU_39670" /old_locus_tag="BSU39670" /EC_number="4.1.2.29" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9226270, 10658656, 11325924, 18310071" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9226270, 10658656, 11325924, 18310071; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-deoxy-5-keto-D-gluconic acid 6-phosphate aldolase" /protein_id="NP_391846.1" /db_xref="EnsemblGenomes-Gn:BSU39670" /db_xref="EnsemblGenomes-Tr:CAB16003" /db_xref="GOA:P42420" /db_xref="InterPro:IPR000771" /db_xref="InterPro:IPR011289" /db_xref="InterPro:IPR013785" /db_xref="SubtiList:BG11125" /db_xref="UniProtKB/Swiss-Prot:P42420" /translation="MAFVSMKELLEDAKREQYAIGQFNINGLQWTKAILQAAQKEQSP VIAAASDRLVDYLGGFKTIAAMVGALIEDMAITVPVVLHLDHGSSAERCRQAIDAGFS SVMIDGSHQPIDENIAMTKEVTDYAAKHGVSVEAEVGTVGGMEDGLVGGVRYADITEC ERIVKETNIDALAAALGSVHGKYQGEPNLGFKEMEAISRMTDIPLVLHGASGIPQDQI KKAITLGHAKININTECMVAWTDETRRMFQENSDLYEPRGYLTPGIEAVEETVRSKMR EFGSAGKAAKQQVG*" /label="iolJ CDS" gene complement(3690336..3691208) /gene="iolJ" /locus_tag="BSU_39670" /old_locus_tag="BSU39670" /label="iolJ gene" downshifts complement(3690340) /Source="Nicolas_upshifts" /id="D2053" /incds=0 /nref=89 /ntot=172 /MaxReadThrough="3.05314" /MaxDrop="6.87265" /score="26.7325466" /energy="-8.2" /TU="NA" /idTUdmin="U3126" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3691229..3692065) /gene="iolI" /locus_tag="BSU_39680" /old_locus_tag="BSU39680" /EC_number="5.3.99.11" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9887260, 11566986, 12112707, 17619021, 16461681, 18310071, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9887260, 11566986, 12112707, 17619021, 16461681, 18310071, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="inosose isomerase" /protein_id="NP_391847.1" /db_xref="EnsemblGenomes-Gn:BSU39680" /db_xref="EnsemblGenomes-Tr:CAB16004" /db_xref="GOA:P42419" /db_xref="InterPro:IPR013022" /db_xref="InterPro:IPR036237" /db_xref="PDB:1I60" /db_xref="PDB:1I6N" /db_xref="SubtiList:BG11124" /db_xref="UniProtKB/Swiss-Prot:P42419" /translation="MKLCFNEATTLENSNLKLDLELCEKHGYDYIEIRTMDKLPEYLK DHSLDDLAEYFQTHHIKPLALNALVFFNNRDEKGHNEIITEFKGMMETCKTLGVKYVV AVPLVTEQKIVKEEIKKSSVDVLTELSDIAEPYGVKIALEFVGHPQCTVNTFEQAYEI VNTVNRDNVGLVLDSFHFHAMGSNIESLKQADGKKIFIYHIDDTEDFPIGFLTDEDRV WPGQGAIDLDAHLSALKEIGFSDVVSVELFRPEYYKLTAEEAIQTAKKTTVDVVSKYF SM*" /label="iolI CDS" gene complement(3691229..3692065) /gene="iolI" /locus_tag="BSU_39680" /old_locus_tag="BSU39680" /label="iolI gene" S_feature complement(3692066..3692150) /Source="Nicolas_S_feature" /locus_tag="new_4074811_4074895_c" /HighExp="M40t90, M0t90, BI, Sw, BC, T5.0H, T0.30H, T4.0H, T3.30H, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.101524" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1524" CDS complement(3692151..3693020) /gene="iolH" /locus_tag="BSU_39690" /old_locus_tag="BSU39690" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9887260, 11566986, 12112707, 23874669; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sugar-phosphate epimerase/isomerase" /protein_id="NP_391848.1" /db_xref="EnsemblGenomes-Gn:BSU39690" /db_xref="EnsemblGenomes-Tr:CAB16005" /db_xref="InterPro:IPR013022" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG11123" /db_xref="UniProtKB/Swiss-Prot:P42418" /translation="MKLALDPSMYRDDLTLEEMVYKTAELGYEYIELSPREDFCPFYK YPKVDSAKIKQLKRLLRDTGVKLSSLLPLYHWAGPDEDRRQAAVRNWKRAIEIAVELE VDLMNSEFSGSKYDPLTSEEKFIKSMDELLPVFEKEGIKLNLQAHPYDFIETHKGAMD MIRALDKDWINLVYSTAHTFFYDDGKGDIETMFDEAGDRLTHVLFADTYNHKAAHGLR YIVNPPDAKVTVHQHLDIGQGEVDFDTIFRKLREMKFDGIATNAVFAWVDERADESSR FMLKKMKEELGLA*" /label="iolH CDS" gene complement(3692151..3693020) /gene="iolH" /locus_tag="BSU_39690" /old_locus_tag="BSU39690" /label="iolH gene" CDS complement(3693040..3694074) /gene="iolG" /locus_tag="BSU_39700" /old_locus_tag="BSU39700" /EC_number="1.1.1.18" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:112095, 11274120, 15678175, 9226270, 16461681, 18310071, 22720735, 25482235, 28431560" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 112095, 11274120, 15678175, 9226270, 16461681, 18310071, 22720735, 25482235, 28431560; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="myo-inositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase" /protein_id="NP_391849.2" /db_xref="EnsemblGenomes-Gn:BSU39700" /db_xref="EnsemblGenomes-Tr:CAB16006" /db_xref="GOA:P26935" /db_xref="InterPro:IPR000683" /db_xref="InterPro:IPR004104" /db_xref="InterPro:IPR023794" /db_xref="InterPro:IPR036291" /db_xref="PDB:3MZ0" /db_xref="PDB:3NT2" /db_xref="PDB:3NT4" /db_xref="PDB:3NT5" /db_xref="PDB:3NTO" /db_xref="PDB:3NTQ" /db_xref="PDB:3NTR" /db_xref="PDB:4L8V" /db_xref="PDB:4L9R" /db_xref="SubtiList:BG10669" /db_xref="UniProtKB/Swiss-Prot:P26935" /translation="MSLRIGVIGTGAIGKEHINRITNKLSGAEIVAVTDVNQEAAQKV VEQYQLNATVYPNDDSLLADENVDAVLVTSWGPAHESSVLKAIKAQKYVFCEKPLATT AEGCMRIVEEEIKVGKRLVQVGFMRRYDSGYVQLKEALDNHVIGEPLMIHCAHRNPTV GDNYTTDMAVVDTLVHEIDVLHWLVNDDYESVQVIYPKKSKNALPHLKDPQIVVIETK GGIVINAEIYVNCKYGYDIQCEIVGEDGIIKLPEPSSISLRKEGRFSTDILMDWQRRF VAAYDVEIQDFIDSIQKKGEVSGPTAWDGYIAAVTTDACVKAQESGQKEKVELKEKPE FYQSFTTVQN*" /label="iolG CDS" gene complement(3693040..3694074) /gene="iolG" /locus_tag="BSU_39700" /old_locus_tag="BSU39700" /label="iolG gene" CDS complement(3694097..3695413) /gene="iolF" /locus_tag="BSU_39710" /old_locus_tag="BSU39710" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11807058, 15849754, 16850406, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11807058, 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="inositol transport protein" /protein_id="NP_391850.2" /db_xref="EnsemblGenomes-Gn:BSU39710" /db_xref="EnsemblGenomes-Tr:CAB16007" /db_xref="GOA:P42417" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11122" /db_xref="UniProtKB/Swiss-Prot:P42417" /translation="MGNTNGDSAFNKRTIAAALANYIDAGSIVAGSAGLSLWVSYLKL SDTQIGLLGALSANAISAAVGALLGGFLADKVGRKAVYTNSMLVYALGICLVLFGVNF PMLLSGYIIIGLSVGADITASWTIIAENAPKKNRARHCGVAQVAWAAGAVVVLLLSVL AGDLGLLGNKIVFAHLLVIALITYILRIRLPESDAWQTKNQPEEAQAEKPAVLNKTSY FDLLKPMYLKSILFLMGVYLVWNLAAGVMGFFMPYIYQQVGGVSANMANLLQMGLFIF TGLGVALIFMPFADKYRKTVFGIAAFMAVIGWTLFLLPVEGLPILLLFIVVIGINNGA GQQANYQLWASEIFPTQYRASAQGLMFFLVRISIGIWSLFVPMIITNFGIGTMAAILL GCVTASMIIGLLFAPNTSGKSLEQIQEELYGSPQSQVKKGTESKIM*" /label="iolF CDS" gene complement(3694097..3695413) /gene="iolF" /locus_tag="BSU_39710" /old_locus_tag="BSU39710" /label="iolF gene" CDS complement(3695428..3696321) /gene="iolE" /locus_tag="BSU_39720" /old_locus_tag="BSU39720" /EC_number="4.2.1.44" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9226270, 14993306, 22720735, 28693424" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9226270, 14993306, 22720735, 28693424; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="scyllo-inosose dehydratase" /protein_id="NP_391851.1" /db_xref="EnsemblGenomes-Gn:BSU39720" /db_xref="EnsemblGenomes-Tr:CAB16008" /db_xref="GOA:P42416" /db_xref="InterPro:IPR013022" /db_xref="InterPro:IPR023952" /db_xref="InterPro:IPR030823" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG11121" /db_xref="UniProtKB/Swiss-Prot:P42416" /translation="MGKNEILWGIAPIGWRNDDMPEIGAGNTLQHLLSDIVVARFQGT EVGGFFPEPAILNKELKLRNLRIAGKWFSSFILRDGLGEAAKTFTLHCEYLQQVNADV AVVSEQTYSVQSLEKNVFTEKPHFTDDEWERLCEGLNHLGEIAAQHGLKLVYHHHLGT GVQTAEEVDRLMAGTDPAHVHLLYDTGHAYISDGDYMGMLEKHIGRIKHVHFKDARLN VMEQCRLEGQSFRQSFLKGMFTVPGDGCIDFREVYQLLLKHSYSGWIVIEAEQDPDVA NPLEYALIARNYIDQQLLDLA*" /label="iolE CDS" gene complement(3695428..3696321) /gene="iolE" /locus_tag="BSU_39720" /old_locus_tag="BSU39720" /label="iolE gene" CDS complement(3696338..3698251) /gene="iolD" /locus_tag="BSU_39730" /old_locus_tag="BSU39730" /EC_number="3.7.1.22" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9887260, 11566986, 12112707, 18310071, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9887260, 11566986, 12112707, 18310071, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3D-(3,5/4)-trihydroxycyclohexane-1,2-dione hydrolase" /protein_id="NP_391852.2" /db_xref="EnsemblGenomes-Gn:BSU39730" /db_xref="EnsemblGenomes-Tr:CAB16009" /db_xref="GOA:P42415" /db_xref="InterPro:IPR000399" /db_xref="InterPro:IPR011766" /db_xref="InterPro:IPR012000" /db_xref="InterPro:IPR012001" /db_xref="InterPro:IPR023757" /db_xref="InterPro:IPR029035" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR030817" /db_xref="SubtiList:BG11120" /db_xref="UniProtKB/Swiss-Prot:P42415" /translation="MGKKIRLTTAQALIKFLNQQYIHVDGKEEPFVEGIFTIFGHGNV LGIGQALEQDAGHLKVYQGKNEQGMAHAAMAYSKQMLRRKIYAVSTSVGPGAANLVAA AGTALANNIPVLLIPADTFATRQPDPVLQQMEQEYSAAITTNDALKPVSRYWDRITRP EQLMSSLLRAFEVMTDPAKAGPATICISQDVEGEAYDFDESFFVKRVHYIDRMQPSER ELQGAAELIKSSKKPVILVGGGAKYSGARDELVAISEAYNIPLVETQAGKSTVEADFA NNLGGMGITGTLAANKAARQADLIIGIGTRYTDFATSSKTAFDFDKAKFLNINVSRMQ AYKLDAFQVVADAKVTLGKLHGLLEGYESEFGTTIRELKDEWLAERERLSKVTFKREA FDPEIKNHFSQEVLNEYADALNTELPQTTALLTINETIPEDSVIICSAGSLPGDLQRL WHSNVPNTYHLEYGYSCMGYEVSGTLGLKLAHPDREVYSIVGDGSFLMLHSELITAIQ YNKKINVLLFDNSGFGCINNLQMDHGSGSYYCEFRTDDNQILNVDYAKVAEGYGAKTY RANTVEELKAALEDAKKQDVSTLIEMKVLPKTMTDGYDSWWHVGVAEVSEQESVQKAY EAKEKKLESAKQY*" /label="iolD CDS" gene complement(3696338..3698251) /gene="iolD" /locus_tag="BSU_39730" /old_locus_tag="BSU39730" /label="iolD gene" CDS complement(3698284..3699261) /gene="iolC" /locus_tag="BSU_39740" /old_locus_tag="BSU39740" /EC_number="2.7.1.92" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9887260, 11566986, 12112707, 18310071, 22720735, 23874669" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9887260, 11566986, 12112707, 18310071, 22720735, 23874669; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="2-deoxy-5-keto-D-gluconic acid kinase" /protein_id="NP_391853.1" /db_xref="EnsemblGenomes-Gn:BSU39740" /db_xref="EnsemblGenomes-Tr:CAB16010" /db_xref="GOA:P42414" /db_xref="InterPro:IPR002173" /db_xref="InterPro:IPR011611" /db_xref="InterPro:IPR022841" /db_xref="InterPro:IPR023314" /db_xref="InterPro:IPR029056" /db_xref="InterPro:IPR030830" /db_xref="SubtiList:BG11119" /db_xref="UniProtKB/Swiss-Prot:P42414" /translation="MKYTFNEEKAFDIVAIGRACIDLNAVEYNRPMEETMTFSKYVGG SPANIAIGSAKLGLKAGFIGKIPDDQHGRFIESYMRKTGVDTTQMIVDQDGHKAGLAF TEILSPEECSILMYRDDVADLYLEPSEVSEDYIANAKMLLVSGTALAKSPSREAVLKA VQYAKKHQVKVVFELDYRPYTWQSSDETAVYYSLVAEQSDIVIGTRDEFDVMENRTGG SNEESVNHLFGHSADLVVIKHGVEGSYAYSKSGEVFRAQAYKTKVLKTFGAGDSYASA FIYGLVSGKDIETALKYGSASASIVVSKHSSSEAMPTAEEIEQLIEAQS*" /label="iolC CDS" gene complement(3698284..3699261) /gene="iolC" /locus_tag="BSU_39740" /old_locus_tag="BSU39740" /label="iolC gene" CDS complement(3699285..3700100) /gene="iolB" /locus_tag="BSU_39750" /old_locus_tag="BSU39750" /EC_number="5.3.1.30" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9887260, 11566986, 12112707, 18310071, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9887260, 11566986, 12112707, 18310071, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-deoxy-D-glucuronic acid isomerase" /protein_id="NP_391854.2" /db_xref="EnsemblGenomes-Gn:BSU39750" /db_xref="EnsemblGenomes-Tr:CAB16011" /db_xref="GOA:P42413" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR021120" /db_xref="InterPro:IPR023770" /db_xref="InterPro:IPR024203" /db_xref="SubtiList:BG11118" /db_xref="UniProtKB/Swiss-Prot:P42413" /translation="MSYLLRKPQSHEVSNGVKLVHEVTTSNSDLTYVEFKVLDLASGS SYTEELKKQEICIVAVTGKITVTDHESTFENIGTRESVFERKPTDSVYISNDRAFEIT AVSDARVALCYSPSEKQLPTKLIKAEDNGIEHRGQFSNKRTVHNILPDSDPSANSLLV VEVYTDSGNWSSYPPHKHDQDNLPEESFLEETYYHELDPGQGFVFQRVYTDDRSIDET MTVGNENVVIVPAGYHPVGVPDGYTSYYLNVMAGPTRKWKFYNDPAHEWILER*" /label="iolB CDS" gene complement(3699285..3700100) /gene="iolB" /locus_tag="BSU_39750" /old_locus_tag="BSU39750" /label="iolB gene" S_feature complement(3700101..3700174) /Source="Nicolas_S_feature" /locus_tag="new_4082846_4082919_c" /HighExp="M40t90, M0t90, Lbtran, BI, Mt0, T0.30H, Sw, BC, S1, T1.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1525" CDS complement(3700175..3701638) /gene="iolA" /locus_tag="BSU_39760" /old_locus_tag="BSU39760" /EC_number="1.2.1.27" /EC_number="1.2.1.18" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10658656, 11566986, 16332250, 18310071, 20971862, 22720735, 26832667" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10658656, 11566986, 16332250, 18310071, 20971862, 22720735, 26832667; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylmalonate-semialdehyde dehydrogenase" /protein_id="NP_391855.1" /db_xref="EnsemblGenomes-Gn:BSU39760" /db_xref="EnsemblGenomes-Tr:CAB16012" /db_xref="GOA:P42412" /db_xref="InterPro:IPR010061" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR023510" /db_xref="PDB:1T90" /db_xref="SubtiList:BG11117" /db_xref="UniProtKB/Swiss-Prot:P42412" /translation="MAEIRKLKNYINGEWVESKTDQYEDVVNPATKEVLCQVPISTKE DIDYAAQTAAEAFKTWSKVAVPRRARILFNFQQLLSQHKEELAHLITIENGKNTKEAL GEVGRGIENVEFAAGAPSLMMGDSLASIATDVEAANYRYPIGVVGGIAPFNFPMMVPC WMFPMAIALGNTFILKPSERTPLLTEKLVELFEKAGLPKGVFNVVYGAHDVVNGILEH PEIKAISFVGSKPVGEYVYKKGSENLKRVQSLTGAKNHTIVLNDANLEDTVTNIVGAA FGSAGERCMACAVVTVEEGIADEFMAKLQEKVADIKIGNGLDDGVFLGPVIREDNKKR TLSYIEKGLEEGARLVCDGRENVSDDGYFVGPTIFDNVTTEMTIWKDEIFAPVLSVIR VKNLKEAIEIANKSEFANGACLFTSNSNAIRYFRENIDAGMLGINLGVPAPMAFFPFS GWKSSFFGTLHANGKDSVDFYTRKKVVTARYPAPDFN*" /label="iolA CDS" gene complement(3700175..3701638) /gene="iolA" /locus_tag="BSU_39760" /old_locus_tag="BSU39760" /label="iolA gene" S_feature complement(3701639..3701843) /Source="Nicolas_S_feature" /locus_tag="new_4084384_4084588_c" /HighExp="M0t90, M40t90, Lbtran, BI, Mt0, T0.30H, BC, S1, T1.0H, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1526" promotor_-35 3701642..3701649 /Source="Nicolas_upshift_promotors" /id="U3125" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.626373626373626" /psig="0.788211788211788" /xcortree=1805 /SigmaFactorBS="gttttttaattttctgatttctgccattctTATTGCCTcctt cattagtaaacACATACACTTGTATGGATGGttccggatagattcatatcaatatcca c" /listShort="S1527" /listLong="iolR, iolS" /label="promotor_-35" promotor_-10 3701665..3701684 /Source="Nicolas_upshift_promotors" /id="U3125" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.626373626373626" /psig="0.788211788211788" /xcortree=1805 /SigmaFactorBS="gttttttaattttctgatttctgccattctTATTGCCTcctt cattagtaaacACATACACTTGTATGGATGGttccggatagattcatatcaatatcca c" /listShort="S1527" /listLong="iolR, iolS" /label="promotor_-10" upshifts 3701672 /Source="Nicolas_upshifts" /id="U3125" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.626373626373626" /psig="0.788211788211788" /xcortree=1805 /SigmaFactorBS="gttttttaattttctgatttctgccattctTATTGCCTcctt cattagtaaacACATACACTTGTATGGATGGttccggatagattcatatcaatatcca c" /listShort="S1527" /listLong="iolR, iolS" /label="upshifts" S_feature 3701679..3701985 /Source="Nicolas_S_feature" /locus_tag="new_4084424_4084730" /HighExp="G180, Paraq, G150, Oxctl, H2O2, G135, Diami, LBGexp, dia5, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.788" /TUlongSig="NA" /TUlongPSig="NA" /label="S1527" promotor_-10 complement(3701825..3701844) /Source="Nicolas_upshift_promotors" /id="U3126" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=331 /SigmaFactorBS="taatataataaaaataatgaaaaaatgtagtgtttatGATTG ACTtatgggtattatgcGATTAGAATATAACCAAGAAatgaccaaaaagtaacctgtt g" /listShort="S1526, mmsA, S1525, iolB, iolC, iolD, iolE, iolF, iolG, iolH, S1524, iolI, iolJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3701843) /Source="Nicolas_upshifts" /id="U3126" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=331 /SigmaFactorBS="taatataataaaaataatgaaaaaatgtagtgtttatGATTG ACTtatgggtattatgcGATTAGAATATAACCAAGAAatgaccaaaaagtaacctgtt g" /listShort="S1526, mmsA, S1525, iolB, iolC, iolD, iolE, iolF, iolG, iolH, S1524, iolI, iolJ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3701845..3701997) /Source="Nicolas_S_feature" /locus_tag="new_4084590_4084742_c" /HighExp="M40t90, M0t90, Lbtran, Diami, Heat, dia5, C30, BI, S1, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1528" promotor_-35 complement(3701859..3701866) /Source="Nicolas_upshift_promotors" /id="U3126" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=331 /SigmaFactorBS="taatataataaaaataatgaaaaaatgtagtgtttatGATTG ACTtatgggtattatgcGATTAGAATATAACCAAGAAatgaccaaaaagtaacctgtt g" /listShort="S1526, mmsA, S1525, iolB, iolC, iolD, iolE, iolF, iolG, iolH, S1524, iolI, iolJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3701945..3701952 /Source="Nicolas_upshift_promotors" /id="U3127" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.95004995004995" /psig="0.99000999000999" /xcortree=329 /SigmaFactorBS="taagagaaggccgtccaaTCTTGCAAaagatatacaccgaTG TTATCATTTTTAAGCAACtattgattaacttttggtttttattatatatttatgttac g" /listShort="iolR, iolS" /listLong="S1529, yxcE, yxcD" /label="promotor_-35" promotor_-10 3701967..3701986 /Source="Nicolas_upshift_promotors" /id="U3127" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.95004995004995" /psig="0.99000999000999" /xcortree=329 /SigmaFactorBS="taagagaaggccgtccaaTCTTGCAAaagatatacaccgaTG TTATCATTTTTAAGCAACtattgattaacttttggtttttattatatatttatgttac g" /listShort="iolR, iolS" /listLong="S1529, yxcE, yxcD" /label="promotor_-10" upshifts 3701987 /Source="Nicolas_upshifts" /id="U3127" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.95004995004995" /psig="0.99000999000999" /xcortree=329 /SigmaFactorBS="taagagaaggccgtccaaTCTTGCAAaagatatacaccgaTG TTATCATTTTTAAGCAACtattgattaacttttggtttttattatatatttatgttac g" /listShort="iolR, iolS" /listLong="S1529, yxcE, yxcD" /label="upshifts" promotor_-10 complement(3701998..3702017) /Source="Nicolas_upshift_promotors" /id="U3128" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=332 /SigmaFactorBS="ctgaatccgcatcagtttcatataaaaaactcctTCTTGAAT ctttacgtaacataaATATATAATAAAAACCAAAAgttaatcaatagttgcttaaaaa t" /listShort="S1528" /listLong="S1526, mmsA, S1525, iolB, iolC, iolD, iolE, iolF, iolG, iolH, S1524, iolI, iolJ" /label="promotor_-10" upshifts complement(3702014) /Source="Nicolas_upshifts" /id="U3128" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=332 /SigmaFactorBS="ctgaatccgcatcagtttcatataaaaaactcctTCTTGAAT ctttacgtaacataaATATATAATAAAAACCAAAAgttaatcaatagttgcttaaaaa t" /listShort="S1528" /listLong="S1526, mmsA, S1525, iolB, iolC, iolD, iolE, iolF, iolG, iolH, S1524, iolI, iolJ" /label="upshifts" promotor_-35 complement(3702033..3702040) /Source="Nicolas_upshift_promotors" /id="U3128" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=332 /SigmaFactorBS="ctgaatccgcatcagtttcatataaaaaactcctTCTTGAAT ctttacgtaacataaATATATAATAAAAACCAAAAgttaatcaatagttgcttaaaaa t" /listShort="S1528" /listLong="S1526, mmsA, S1525, iolB, iolC, iolD, iolE, iolF, iolG, iolH, S1524, iolI, iolJ" /label="promotor_-35" CDS 3702054..3702809 /gene="iolR" /locus_tag="BSU_39770" /old_locus_tag="BSU39770" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9887260, 11566986, 11807058, 18310071, 24878601, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9887260, 11566986, 11807058, 18310071, 24878601, 26735940; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of the iol operon (DeoR family)" /protein_id="NP_391856.1" /db_xref="EnsemblGenomes-Gn:BSU39770" /db_xref="EnsemblGenomes-Tr:CAB16013" /db_xref="GOA:P46337" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR014036" /db_xref="InterPro:IPR018356" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11364" /db_xref="UniProtKB/Swiss-Prot:P46337" /translation="MKLMRIQEMEEYILSHGTVSLDELCQVFNVSKNTVRRDINKLTE KGAIEKVYGGVTSIEKTALVPFENRTIQHQDEKTKIAHYASRFIEDHDLVFIDSGTTT KSILDTLDPAKNVTILTNSLDIINAASALKNINLIIIGNNYKRKTRSFVGMDDPAMLD KYNINKAFMSATGTTLTHGLTNSDLLEYEIKKRISEKAKEVYLLADHSKFGKSTLLTY APFDRLHCIVTSQPLDDEYTQYCNEHQIGIHLA*" /label="iolR CDS" gene 3702054..3702809 /gene="iolR" /locus_tag="BSU_39770" /old_locus_tag="BSU39770" /label="iolR gene" promotor_-35 3702788..3702794 /Source="Nicolas_upshift_promotors" /id="U3129" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.841158841158841" /psig="0.994005994005994" /xcortree=2059 /SigmaFactorBS="acacgcagtactgcaatgagcatcaAATCGGCattcatctgg cctaACGTTTACAATAGTGTTGAGagtctatcatccattttattctaggaggcagatc a" /listShort="iolS, S1529, yxcE, yxcD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3702809..3702828 /Source="Nicolas_upshift_promotors" /id="U3129" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.841158841158841" /psig="0.994005994005994" /xcortree=2059 /SigmaFactorBS="acacgcagtactgcaatgagcatcaAATCGGCattcatctgg cctaACGTTTACAATAGTGTTGAGagtctatcatccattttattctaggaggcagatc a" /listShort="iolS, S1529, yxcE, yxcD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3702823 /Source="Nicolas_upshifts" /id="U3129" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.841158841158841" /psig="0.994005994005994" /xcortree=2059 /SigmaFactorBS="acacgcagtactgcaatgagcatcaAATCGGCattcatctgg cctaACGTTTACAATAGTGTTGAGagtctatcatccattttattctaggaggcagatc a" /listShort="iolS, S1529, yxcE, yxcD" /GFF_Attribute="listLong" /label="upshifts" CDS 3702863..3703795 /gene="iolS" /locus_tag="BSU_39780" /old_locus_tag="BSU39780" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9226270, 15019785, 22720735, 24330391; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aldo-keto reductase" /protein_id="NP_391857.1" /db_xref="EnsemblGenomes-Gn:BSU39780" /db_xref="EnsemblGenomes-Tr:CAB16014" /db_xref="GOA:P46336" /db_xref="InterPro:IPR018170" /db_xref="InterPro:IPR020471" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="PDB:1PYF" /db_xref="PDB:1PZ0" /db_xref="SubtiList:BG11363" /db_xref="UniProtKB/Swiss-Prot:P46336" /translation="MKKAKLGKSDLQVFPIGLGTNAVGGHNLYPNLNEETGKELVREA IRNGVTMLDTAYIYGIGRSEELIGEVLREFNREDVVIATKAAHRKQGNDFVFDNSPDF LKKSVDESLKRLNTDYIDLFYIHFPDEHTPKDEAVNALNEMKKAGKIRSIGVSNFSLE QLKEANKDGLVDVLQGEYNLLNREAEKTFFPYTKEHNISFIPYFPLVSGLLAGKYTED TTFPEGDLRNEQEHFKGERFKENIRKVNKLAPIAEKHNVDIPHIVLAWYLARPEIDIL IPGAKRADQLIDNIKTADVTLSQEDISFIDKLFA*" /label="iolS CDS" gene 3702863..3703795 /gene="iolS" /locus_tag="BSU_39780" /old_locus_tag="BSU39780" /label="iolS gene" downshifts 3703797 /Source="Nicolas_upshifts" /id="D2054" /incds=0 /nref=154 /ntot=259 /MaxReadThrough="4.521" /MaxDrop="7.17874" /score="39.70215" /energy="-17.1" /TU="U3129" /idTUdmin="U3127" /TUdmin=6 /isTUend="TRUE" /label="downshifts" promotor_-35 3703874..3703881 /Source="Nicolas_upshift_promotors" /id="U3130" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.703296703296703" /psig="0.835164835164835" /xcortree=2016 /SigmaFactorBS="ataaattcctaaataactgattttgaagcaaaaCCTTACAAa atgagccataaaTCCGATAAAATAAAGGTAGTttatctcagaaagaaagtgattgaga a" /listShort="S1529, yxcE, yxcD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3703895..3703914 /Source="Nicolas_upshift_promotors" /id="U3130" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.703296703296703" /psig="0.835164835164835" /xcortree=2016 /SigmaFactorBS="ataaattcctaaataactgattttgaagcaaaaCCTTACAAa atgagccataaaTCCGATAAAATAAAGGTAGTttatctcagaaagaaagtgattgaga a" /listShort="S1529, yxcE, yxcD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3703901..3704056 /Source="Nicolas_S_feature" /locus_tag="new_4086646_4086801" /HighExp="dia5, LPhT, Diami, Etha, dia15, LBGstat, M9-stat, Lbtran, T0.30H, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.835, 0.994" /TUlongSig="SigA" /TUlongPSig="0.99" /label="S1529" upshifts 3703901 /Source="Nicolas_upshifts" /id="U3130" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.703296703296703" /psig="0.835164835164835" /xcortree=2016 /SigmaFactorBS="ataaattcctaaataactgattttgaagcaaaaCCTTACAAa atgagccataaaTCCGATAAAATAAAGGTAGTttatctcagaaagaaagtgattgaga a" /listShort="S1529, yxcE, yxcD" /GFF_Attribute="listLong" /label="upshifts" CDS 3704057..3704707 /gene="yxcE" /locus_tag="BSU_39790" /old_locus_tag="BSU39790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391858.1" /db_xref="EnsemblGenomes-Gn:BSU39790" /db_xref="EnsemblGenomes-Tr:CAB16015" /db_xref="GOA:P46335" /db_xref="SubtiList:BG11362" /db_xref="UniProtKB/Swiss-Prot:P46335" /translation="MKLKYVKALVAVTVALGVLLPSTISHAKSFSGRSSSSYSSRSSS SSYSGSYKSSPKSSYSSGSSSSSKKSKTSDDSSSSISLKKKPSEKASSSSSKKSSGTF SGATSKVTGKTYSGKTSKAYVGGRYVSVNHYYHAGFAPSGWFGYYSGFTMGMFMISMM HPWGYTYHPVGGPGYVSYGASPIAWIVDIIALIIILIIVIALIRAFKAPKTYRRRF*" /label="yxcE CDS" gene 3704057..3704707 /gene="yxcE" /locus_tag="BSU_39790" /old_locus_tag="BSU39790" /label="yxcE gene" CDS 3704711..3705019 /gene="yxcD" /locus_tag="BSU_39800" /old_locus_tag="BSU39800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391859.1" /db_xref="EnsemblGenomes-Gn:BSU39800" /db_xref="EnsemblGenomes-Tr:CAB16016" /db_xref="InterPro:IPR020516" /db_xref="SubtiList:BG11361" /db_xref="UniProtKB/Swiss-Prot:P46334" /translation="MRLILNEQEIVDGICVYISNEEDIYPEDVEVKELSYNKRTGFFA EATFGLHHKQLMSDDISEGIIQFLEEYHNFNPDVTVVELQFDKKKGFSALVFVNEAEE *" /label="yxcD CDS" gene 3704711..3705019 /gene="yxcD" /locus_tag="BSU_39800" /old_locus_tag="BSU39800" /label="yxcD gene" downshifts 3705021 /Source="Nicolas_upshifts" /id="D2055" /incds=0 /nref=185 /ntot=262 /MaxReadThrough="1.91541" /MaxDrop="6.4314" /score="14.1581732" /energy="-8.8" /TU="NA" /idTUdmin="U3130" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 3705163..3705169 /Source="Nicolas_upshift_promotors" /id="U3131" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=218 /SigmaFactorBS="tataaagtttccgttttttcaaaacaaaTGTTTCAaatgaga taggaaatGGGTACTAATCTATTAACTttgttacatatttttagatactcattggctc a" /listShort="csbC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3705185..3705203 /Source="Nicolas_upshift_promotors" /id="U3131" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=218 /SigmaFactorBS="tataaagtttccgttttttcaaaacaaaTGTTTCAaatgaga taggaaatGGGTACTAATCTATTAACTttgttacatatttttagatactcattggctc a" /listShort="csbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3705195 /Source="Nicolas_upshifts" /id="U3131" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=218 /SigmaFactorBS="tataaagtttccgttttttcaaaacaaaTGTTTCAaatgaga taggaaatGGGTACTAATCTATTAACTttgttacatatttttagatactcattggctc a" /listShort="csbC" /GFF_Attribute="listLong" /label="upshifts" CDS 3705257..3706642 /gene="csbC" /locus_tag="BSU_39810" /old_locus_tag="BSU39810" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10376822, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative metabolite transporter" /protein_id="NP_391860.1" /db_xref="EnsemblGenomes-Gn:BSU39810" /db_xref="EnsemblGenomes-Tr:CAB16017" /db_xref="GOA:P46333" /db_xref="InterPro:IPR003663" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11360" /db_xref="UniProtKB/Swiss-Prot:P46333" /translation="MKKDTRKYMIYFFGALGGLLYGYDTGVISGALLFINNDIPLTTL TEGLVVSMLLLGAIFGSALSGTCSDRWGRRKVVFVLSIIFIIGALACAFSQTIGMLIA SRVILGLAVGGSTALVPVYLSEMAPTKIRGTLGTMNNLMIVTGILLAYIVNYLFTPFE AWRWMVGLAAVPAVLLLIGIAFMPESPRWLVKRGSEEEARRIMNITHDPKDIEMELAE MKQGEAEKKETTLGVLKAKWIRPMLLIGVGLAIFQQAVGINTVIYYAPTIFTKAGLGT SASALGTMGIGILNVIMCITAMILIDRVGRKKLLIWGSVGITLSLAALSGVLLTLGLS ASTAWMTVVFLGVYIVFYQATWGPVVWVLMPELFPSKARGAATGFTTLVLSAANLIVS LVFPLMLSAMGIAWVFMVFSVICLLSFFFAFYMVPETKGKSLEEIEASLKKRFKKKKS TQNQVLNERTL*" /label="csbC CDS" gene 3705257..3706642 /gene="csbC" /locus_tag="BSU_39810" /old_locus_tag="BSU39810" /label="csbC gene" downshifts 3706628 /Source="Nicolas_upshifts" /id="D2056" /incds=0 /nref=69 /ntot=115 /MaxReadThrough="4.59405" /MaxDrop="7.32264" /score="22.9943012" /energy="-16.4" /TU="NA" /idTUdmin="U3131" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 3706673..3707223 /Source="Nicolas_S_feature" /locus_tag="new_4089418_4089968" /HighExp="Etha, C30, C90, Gly, Sw, G135, Fru, HiTm, M/G, Mal" /AntisenseName="htpG" /AntisenseCor="7.4766600377621104E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1530" CDS complement(3706684..3708564) /gene="htpG" /locus_tag="BSU_39820" /old_locus_tag="BSU39820" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9150201, 10323241, 11407116, 12511492, 22226636, 26743745, 27723736, 28363677, 28383119, 28784328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9150201, 10323241, 11407116, 12511492, 22226636, 26743745, 27723736, 28363677, 28383119, 28784328; Product type f: factor" /codon_start=1 /transl_table=11 /product="class III heat-shock protein (ATP-dependent molecular chaperone HSP90)" /protein_id="NP_391861.1" /db_xref="EnsemblGenomes-Gn:BSU39820" /db_xref="EnsemblGenomes-Tr:CAB16018" /db_xref="GOA:P46208" /db_xref="InterPro:IPR001404" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR019805" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR020575" /db_xref="InterPro:IPR036890" /db_xref="InterPro:IPR037196" /db_xref="SubtiList:BG11359" /db_xref="UniProtKB/Swiss-Prot:P46208" /translation="MAKKEFKAESKRLLDMMINSIYTQKEIFLRELISNSSDAIDKIY YKALTDDALTFDKDSYYIKVAADKDARTLTISDTGIGMTKDELEQHLGTIAKSGSLAF KKENELKDGHDIIGQFGVGFYAAFMVADVVTVISKALGSEEAYKWESAGADGYTIEPC EKDSVGTDIILKIKENTEDDSYDEFLEEYRLKAIIKKYSDFIRYPIKMDTTINKPKEG SENEFEEVQEEQTVNSMVPIWRKNKSELTDEDYEKFYAEKHYGFDKPLTHVHISVDGA VRYNAILFVPENMPFDYYSKEYEKGLELYSNGVLIMNKCADLLPDHFSFVKGMVDSED LSLNISREMLQHDRQLKLIAKNISKKIKSELQSLLKKDREKYETFYKSFGRQLKFGVY NDFGANKDQLKDLLLFYSSKEKKLVSLDEYVSRMPEEQKFIYYATGDSYDRIEKLPQT EMVADKGYEILYFTEDIDEFAIKMLASYQEKEFKSVSSGDLGIDTDEDQKQSEEEESK YKDLFEEMKNILSDKVKNVRISKRLKSHPVCLAADGEVTIEMEKILNAMPDSQNVKAE KVLEINPNHEVFQTLQDAFEQDKEKLSLYTNLLYNQALLIEGLPIQDPVEFTNNICKV MV*" /label="htpG CDS" gene complement(3706684..3708564) /gene="htpG" /locus_tag="BSU_39820" /old_locus_tag="BSU39820" /label="htpG gene" downshifts complement(3706690) /Source="Nicolas_upshifts" /id="D2057" /incds=0 /nref=169 /ntot=288 /MaxReadThrough="0.81611" /MaxDrop="6.49379" /score="34.0973015" /energy="-16.4" /TU="NA" /idTUdmin="U3132" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" S_feature complement(3708565..3708662) /Source="Nicolas_S_feature" /locus_tag="new_4091310_4091407_c" /HighExp="Lbtran, S1, LBGtran, C90, M40t45, M9-tran, GM 150, dia0, T-2.40H, dia5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="SigA" /TUlongPSig="0.995" /label="S1531" promotor_-10 complement(3708653..3708672) /Source="Nicolas_upshift_promotors" /id="U3132" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.69030969030969" /psig="0.996003996003996" /xcortree=2301 /SigmaFactorBS="tcttttttatgagaatgagtgagaaaaaGAGTGAAAacaaat ccaactaaTGTTAAATTTACATATATATgcatctatcaatctaattgacaattgtcat c" /listShort="S1531, htpG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3708662) /Source="Nicolas_upshifts" /id="U3132" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.69030969030969" /psig="0.996003996003996" /xcortree=2301 /SigmaFactorBS="tcttttttatgagaatgagtgagaaaaaGAGTGAAAacaaat ccaactaaTGTTAAATTTACATATATATgcatctatcaatctaattgacaattgtcat c" /listShort="S1531, htpG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3708687..3708694) /Source="Nicolas_upshift_promotors" /id="U3132" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.69030969030969" /psig="0.996003996003996" /xcortree=2301 /SigmaFactorBS="tcttttttatgagaatgagtgagaaaaaGAGTGAAAacaaat ccaactaaTGTTAAATTTACATATATATgcatctatcaatctaattgacaattgtcat c" /listShort="S1531, htpG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3708732..3708983) /gene="yxcA" /locus_tag="BSU_39830" /old_locus_tag="BSU39830" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391862.1" /db_xref="EnsemblGenomes-Gn:BSU39830" /db_xref="EnsemblGenomes-Tr:CAB16019" /db_xref="GOA:P46332" /db_xref="SubtiList:BG11358" /db_xref="UniProtKB/Swiss-Prot:P46332" /translation="MKVQHKKELKFYCIVTIPSAFVVLTVISFLLQEITFPVTASAFL NASWHNLLFLIPFGLFFYPVHIWMKREFGRWNDTEKKRG*" /label="yxcA CDS" gene complement(3708732..3708983) /gene="yxcA" /locus_tag="BSU_39830" /old_locus_tag="BSU39830" /label="yxcA gene" downshifts complement(3708750) /Source="Nicolas_upshifts" /id="D2058" /incds=0 /nref=11 /ntot=62 /MaxReadThrough="3.50049" /MaxDrop="5.56962" /score="-3.89567108" /energy="-6.7" /TU="U3133" /idTUdmin="U3133" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" misc_feature complement(3709005..3709024) /Source="Nicolas_upshift_promotors" /id="U3133" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.928071928071928" /psig="0.995004995004995" /xcortree=2181 /SigmaFactorBS="gtcttcccgctatgtgcagtgataaacatgcgagaaaagaaa ggccagcaTATGTTAAGATGAATTAGAAattgttgggaggtttgtatgtttgaaggta c" /listShort="yxcA" /listLong="S1531, htpG" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3709014) /Source="Nicolas_upshifts" /id="U3133" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.928071928071928" /psig="0.995004995004995" /xcortree=2181 /SigmaFactorBS="gtcttcccgctatgtgcagtgataaacatgcgagaaaagaaa ggccagcaTATGTTAAGATGAATTAGAAattgttgggaggtttgtatgtttgaaggta c" /listShort="yxcA" /listLong="S1531, htpG" /label="upshifts" promotor_-35 3709047..3709053 /Source="Nicolas_upshift_promotors" /id="U3134" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=245 /SigmaFactorBS="taattcatcttaacatatgctggcctttcttttctcgcaTGT TTATcactgcacatagcGGGAAGACAAATAGAAAAAggaggtctcgtatcatgggaag a" /listShort="yxbG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3709067..3709085 /Source="Nicolas_upshift_promotors" /id="U3134" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=245 /SigmaFactorBS="taattcatcttaacatatgctggcctttcttttctcgcaTGT TTATcactgcacatagcGGGAAGACAAATAGAAAAAggaggtctcgtatcatgggaag a" /listShort="yxbG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3709068 /Source="Nicolas_upshifts" /id="U3134" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=245 /SigmaFactorBS="taattcatcttaacatatgctggcctttcttttctcgcaTGT TTATcactgcacatagcGGGAAGACAAATAGAAAAAggaggtctcgtatcatgggaag a" /listShort="yxbG" /GFF_Attribute="listLong" /label="upshifts" CDS 3709100..3709921 /gene="yxbG" /locus_tag="BSU_39840" /old_locus_tag="BSU39840" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10746760; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391863.2" /db_xref="EnsemblGenomes-Gn:BSU39840" /db_xref="EnsemblGenomes-Tr:CAB16020" /db_xref="GOA:P46331" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11357" /db_xref="UniProtKB/Swiss-Prot:P46331" /translation="MGRLENKTAVITGAATGIGQATAEVFANEGARVIIGDINKDQME ETVDAIRKNGGQAESFHLDVSDENSVKAFADQIKDACGTIDILFNNAGVDQEGGKVHE YPVDLFDRIIAVDLRGTFLCSKYLIPLMLENGGSIINTSSMSGRAADLDRSGYNAAKG GITNLTKAMAIDYARNGIRVNSISPGTIETPLIDKLAGTKEQEMGEQFREANKWITPL GRLGQPKEMATVALFLASDDSSYVTGEDITADGGIMAYTWPGKMLIEEKWKEETK*" /label="yxbG CDS" gene 3709100..3709921 /gene="yxbG" /locus_tag="BSU_39840" /old_locus_tag="BSU39840" /label="yxbG gene" downshifts 3709905 /Source="Nicolas_upshifts" /id="D2059" /incds=0 /nref=22 /ntot=67 /MaxReadThrough="2.87575" /MaxDrop="5.67438" /score="22.9485028" /energy="-10.5" /TU="U3134" /idTUdmin="U3134" /TUdmin="-221" /isTUend="FALSE" /label="downshifts" CDS complement(3709950..3711092) /gene="yxbF" /locus_tag="BSU_39850" /old_locus_tag="BSU39850" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11160890; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_391864.1" /db_xref="EnsemblGenomes-Gn:BSU39850" /db_xref="EnsemblGenomes-Tr:CAB16021" /db_xref="GOA:P46330" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="SubtiList:BG11356" /db_xref="UniProtKB/Swiss-Prot:P46330" /translation="MPESAEAQVKEALLALLKDRDIQHITMKEIAEKAKVSRGSLYLY YEDKFSIIEDVIEDMKEGLGKALFDAFSHMDTLHLNKKRQTVHPTLSFVHEHRSFFSV MMNRGHFHRFFKDVFQQDVLLAPIHVNLTPIERDIYGHYRALYTYAIILYWLNEDAAA SPEAISQKVWELVSQKRFYWLFGKAVPGEREKEKQIDRRVVRTREALQKAFLDVLAEK QDYAGITISDITRKSNIRRATFYDHYANKEELLQTMIQRSCAEIIDHLTIASSPNEFS LKEAEKALAILLSALSNMPIVHFLNREWGVPHVIPDMFKALESFYLHQQTDIHAEKKL YAHYVSAMIIGLLLYRLDEGKAHPPEVLAREFLQFLDVKKYKVVLL*" /label="yxbF CDS" gene complement(3709950..3711092) /gene="yxbF" /locus_tag="BSU_39850" /old_locus_tag="BSU39850" /label="yxbF gene" downshifts complement(3709960) /Source="Nicolas_upshifts" /id="D2060" /incds=0 /nref=10 /ntot=163 /MaxReadThrough="1.63217" /MaxDrop="3.79969" /score="-0.564494299" /energy="-10.5" /TU="NA" /idTUdmin="U3135" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3711093..3711192) /Source="Nicolas_S_feature" /locus_tag="new_4093838_4093937_c" /HighExp="H2O2, Diami, dia15, Paraq, G180, G135, G150, dia5, Oxctl, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1532" promotor_-10 complement(3711180..3711199) /Source="Nicolas_upshift_promotors" /id="U3135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.926073926073926" /psig="0.997002997002997" /xcortree=1836 /SigmaFactorBS="tttacttgctgttccattgtaaaatccccctCATTTGCTttc ttcttttctcGGACCTATTATAAGGTGGTAccttttctgtaagaaagacaacggtgaa c" /listShort="S1532, yxbF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3711191) /Source="Nicolas_upshifts" /id="U3135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.926073926073926" /psig="0.997002997002997" /xcortree=1836 /SigmaFactorBS="tttacttgctgttccattgtaaaatccccctCATTTGCTttc ttcttttctcGGACCTATTATAAGGTGGTAccttttctgtaagaaagacaacggtgaa c" /listShort="S1532, yxbF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3711213..3711220) /Source="Nicolas_upshift_promotors" /id="U3135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.926073926073926" /psig="0.997002997002997" /xcortree=1836 /SigmaFactorBS="tttacttgctgttccattgtaaaatccccctCATTTGCTttc ttcttttctcGGACCTATTATAAGGTGGTAccttttctgtaagaaagacaacggtgaa c" /listShort="S1532, yxbF" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3711235..3712572 /gene="aldX" /locus_tag="BSU_39860" /old_locus_tag="BSU39860" /EC_number="1.2.1.3" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aldehyde dehydrogenase" /protein_id="NP_391865.2" /db_xref="EnsemblGenomes-Gn:BSU39860" /db_xref="EnsemblGenomes-Tr:CAB16022" /db_xref="GOA:P46329" /db_xref="InterPro:IPR012394" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG11355" /db_xref="UniProtKB/Swiss-Prot:P46329" /translation="MEQQVKDDIQRVFQLQKKQQKALRASTAEQRREKLQRFLDSVIA HEEEIIEAIRKDVRKPYHEVKKAEIEGTKKAIRDNMNNLEQWMAPKEVGSSLSPDANG ILMYEPKGVTLILGPWNYPFMLTMAPLAASLAAGNSAIVKLSDFTMNTSNIAAKVIRD AFDEKEVAIFEGEVEVATELLDQPFDHIFFTGSTNVGKIVMTAAAKHLASVTLELGGK SPTIIDSEYDLMDAAKKIAVGKFVNAGQTCIAPDYLFIKKDVQDRFAGILQTVVNAGF MEDDHTPDRSKFTQIVNDRNFNRVKDLFDDAIERGAEVVFGGVFDASDRTISPTVLKN VTPDMKIMQEEIFASILPMMNYEDIDEVIDYVNDRDKPLALYVFSKNQDLIDNVLQHT TSGNAAINDVVVHFSDVNLPFGGVNTSGIGSYHGVYGFKEFSHEKGVFIQAAE*" /label="aldX CDS" gene 3711235..3712572 /gene="aldX" /locus_tag="BSU_39860" /old_locus_tag="BSU39860" /label="aldX gene" S_feature complement(3711977..3712577) /Source="Nicolas_S_feature" /locus_tag="new_4094722_4095322_c" /HighExp="T1.30H, T2.30H, T2.0H, T1.0H, T-2.40H, T3.0H, T3.30H, T0.0H, T-0.40H, T-3.40H" /AntisenseName="aldX" /AntisenseCor="-0.39894728806999702" /AntisenseRegPval="-11" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1533" CDS complement(3712611..3713090) /gene="yxbD" /locus_tag="BSU_39870" /old_locus_tag="BSU39870" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_391866.2" /db_xref="EnsemblGenomes-Gn:BSU39870" /db_xref="EnsemblGenomes-Tr:CAB16023" /db_xref="GOA:P46328" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11354" /db_xref="UniProtKB/Swiss-Prot:P46328" /translation="MNIIPTCQVPKDLVSAFFQKHWGSPQMVISSGIYNCDELDGYGM LNDDNQIVGLITYIFEEDACEIISLDSVIENKGIGTALLEKAEEACRERNIKQIKLIT TNDNIHALAFYQKRGYRLDRLFVNAVETARKMKPEIPLLADNKIPIRDELLLVKELQ* " /label="yxbD CDS" gene complement(3712611..3713090) /gene="yxbD" /locus_tag="BSU_39870" /old_locus_tag="BSU39870" /label="yxbD gene" downshifts complement(3712622) /Source="Nicolas_upshifts" /id="D2061" /incds=0 /nref=1 /ntot=39 /MaxReadThrough="3.82941" /MaxDrop="2.52984" /score="-7.41869067" /energy="-10.9" /TU="U3136" /idTUdmin="U3136" /TUdmin="-616" /isTUend="FALSE" /label="downshifts" CDS complement(3713170..3714162) /gene="yxbC" /locus_tag="BSU_39880" /old_locus_tag="BSU39880" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391867.1" /db_xref="EnsemblGenomes-Gn:BSU39880" /db_xref="EnsemblGenomes-Tr:CAB16024" /db_xref="GOA:P46327" /db_xref="InterPro:IPR003347" /db_xref="PDB:1VRB" /db_xref="SubtiList:BG11353" /db_xref="UniProtKB/Swiss-Prot:P46327" /translation="MSAVTESVLESIISPVTMSEFLEEYWPVKPLVARGEVERFTSIP GFEKVRTLENVLAIYNNPVMVVGDAVIEESEGITDRFLVSPAEALEWYEKGAALEFDF TDLFIPQVRRWIEKLKAELRLPAGTSSKAIVYAAKNGGGFKAHFDAYTNLIFQIQGEK TWKLAKNENVSNPMQHYDLSEAPYYPDDLQSYWKGDPPKEDLPDAEIVNLTPGTMLYL PRGLWHSTKSDQATLALNITFGQPAWLDLMLAALRKKLISDNRFRELAVNHQSLHESS KSELNGYLESLIQTLSENAETLTPEQIFQSQDSDFDPYQSTQLVFRQLLTSYKF*" /label="yxbC CDS" gene complement(3713170..3714162) /gene="yxbC" /locus_tag="BSU_39880" /old_locus_tag="BSU39880" /label="yxbC gene" downshifts complement(3713194) /Source="Nicolas_upshifts" /id="D2062" /incds=0 /nref=5 /ntot=98 /MaxReadThrough="5.86537" /MaxDrop="5.28716" /score="-7.41869067" /energy="-10.9" /TU="U3136" /idTUdmin="U3136" /TUdmin="-1188" /isTUend="FALSE" /label="downshifts" downshifts 3714152 /Source="Nicolas_upshifts" /id="D2063" /incds=0 /nref=2 /ntot=56 /MaxReadThrough="1.15059" /MaxDrop="3.74519" /score="9.93493822" /energy="-12.4" /TU="NA" /idTUdmin="U3134" /TUdmin=4026 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3714185..3714204) /Source="Nicolas_upshift_promotors" /id="U3136" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=476 /SigmaFactorBS="acaactaaatattataatcctctgataattctgtcaaTATTT ACTtttagaaaaaaatgTTATATCTTTGTGGTGAAGTtactttttttgggagggataa t" /listShort="yxbC, yxbD, S1533" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3714203) /Source="Nicolas_upshifts" /id="U3136" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=476 /SigmaFactorBS="acaactaaatattataatcctctgataattctgtcaaTATTT ACTtttagaaaaaaatgTTATATCTTTGTGGTGAAGTtactttttttgggagggataa t" /listShort="yxbC, yxbD, S1533" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3714219..3714226) /Source="Nicolas_upshift_promotors" /id="U3136" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=476 /SigmaFactorBS="acaactaaatattataatcctctgataattctgtcaaTATTT ACTtttagaaaaaaatgTTATATCTTTGTGGTGAAGTtactttttttgggagggataa t" /listShort="yxbC, yxbD, S1533" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3714225..3714232 /Source="Nicolas_upshift_promotors" /id="U3137" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=477 /SigmaFactorBS="cttcaccacaaagatataacatttttttctaaaagtaaaTAT TGACAgaattatcagaggaTTATAATATTTAGTTGTGCGtgatagcctatttttttac a" /listShort="S1534, yxbB, aslA, yxnB, asnH, yxaM" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3714246..3714670 /Source="Nicolas_S_feature" /locus_tag="new_4096991_4097415" /HighExp="T2.0H, T5.0H, M9-stat, T3.0H, T1.30H, T1.0H, T3.30H, T2.30H, T4.0H, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.998942" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1534" upshifts 3714246 /Source="Nicolas_upshifts" /id="U3137" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=477 /SigmaFactorBS="cttcaccacaaagatataacatttttttctaaaagtaaaTAT TGACAgaattatcagaggaTTATAATATTTAGTTGTGCGtgatagcctatttttttac a" /listShort="S1534, yxbB, aslA, yxnB, asnH, yxaM" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3714247..3714266 /Source="Nicolas_upshift_promotors" /id="U3137" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=477 /SigmaFactorBS="cttcaccacaaagatataacatttttttctaaaagtaaaTAT TGACAgaattatcagaggaTTATAATATTTAGTTGTGCGtgatagcctatttttttac a" /listShort="S1534, yxbB, aslA, yxnB, asnH, yxaM" /GFF_Attribute="listLong" /label="promotor_-10" misc_RNA 3714252..3714664 /gene="srlX" /locus_tag="BSU_misc_RNA_86" /product="putative small RNA or mRNA leader sequence" /experiment="publication(s) with functional evidences, PMID:20525796" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20525796; Product type n: RNA" /label="srlX RNA" gene 3714252..3714664 /gene="srlX" /locus_tag="BSU_misc_RNA_86" /label="srlX gene" upshifts complement(3714272) /Source="Nicolas_upshifts" /id="U3138" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=719 /SigmaFactorBS="agacgaggtttcttataagcctttTTCATccttttcCCTCCT TCCTTGTAAaaaaataggctatcacgcacaactaaatattataatcctctgataattc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3714282..3714296) /Source="Nicolas_upshift_promotors" /id="U3138" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=719 /SigmaFactorBS="agacgaggtttcttataagcctttTTCATccttttcCCTCCT TCCTTGTAAaaaaataggctatcacgcacaactaaatattataatcctctgataattc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3714304..3714308) /Source="Nicolas_upshift_promotors" /id="U3138" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=719 /SigmaFactorBS="agacgaggtttcttataagcctttTTCATccttttcCCTCCT TCCTTGTAAaaaaataggctatcacgcacaactaaatattataatcctctgataattc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3714636 /Source="Nicolas_upshifts" /id="D2064" /incds=0 /nref=2 /ntot=9 /MaxReadThrough="8.39077" /MaxDrop="5.02548" /score="9.93493822" /energy="-12.4" /TU="U3137" /idTUdmin="U3134" /TUdmin=4510 /isTUend="FALSE" /label="downshifts" CDS 3714671..3715405 /gene="yxbB" /locus_tag="BSU_39890" /old_locus_tag="BSU39890" /EC_number="2.1.1.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15941984, 20185509; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative S-adenosylmethionine-dependent methyltransferase" /protein_id="NP_391868.1" /db_xref="EnsemblGenomes-Gn:BSU39890" /db_xref="EnsemblGenomes-Tr:CAB16025" /db_xref="GOA:P46326" /db_xref="InterPro:IPR013216" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11352" /db_xref="UniProtKB/Swiss-Prot:P46326" /translation="MITAEECRTYKEFVDLYQSYLYPLLGARLSRMYSPKNKVIIDMG TGPGYLSIQLAKRTNAHVHAVDINPAMHEIAQEEAKKSGVSSLISFDLEDVHHLSYAD QYADFIVSYSCLHHWEDVVKGLKECYRVLAPGGKIVILDTFNPQGSHLEIMRKQIKEP EYFRFVREAFEESYSFEDIHQFVQDAGIPNYSLETFHFLPEDFIESLDELEDAPLWEQ NDQSTDHEIESVTWMLTIEKEKEGAL*" /label="yxbB CDS" gene 3714671..3715405 /gene="yxbB" /locus_tag="BSU_39890" /old_locus_tag="BSU39890" /label="yxbB gene" CDS 3715405..3715674 /gene="yxbA" /locus_tag="BSU_39900" /old_locus_tag="BSU39900" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 17083466" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391869.1" /db_xref="EnsemblGenomes-Gn:BSU39900" /db_xref="EnsemblGenomes-Tr:CAB16026" /db_xref="InterPro:IPR008792" /db_xref="SubtiList:BG11351" /db_xref="UniProtKB/Swiss-Prot:P46325" /translation="MINESTVLSKNPEMPSRKYLKSIIIEPGITLNEMASDIYNHIDG KVSIHDICSKIVNEYDVDYQTCLEDCMELFELLIDHEAIKVKQGA*" /label="yxbA CDS" gene 3715405..3715674 /gene="yxbA" /locus_tag="BSU_39900" /old_locus_tag="BSU39900" /label="yxbA gene" CDS 3715678..3716160 /gene="yxnB" /locus_tag="BSU_39910" /old_locus_tag="BSU39910" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20185509" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391870.1" /db_xref="EnsemblGenomes-Gn:BSU39910" /db_xref="EnsemblGenomes-Tr:CAB16027" /db_xref="SubtiList:BG14166" /db_xref="UniProtKB/Swiss-Prot:O34704" /translation="MEKQKVLALPDDVHELSTHRSKSIVNYIITLLAFAKKQGLTHQD IVSWIHEQYEERGYYDEWRHINSQQPVGSFVELFIKGRRLLYDKIELFETEDKYVVNT HTWYEKEPSEAFFYFEIDPEEFSAYASILAIENAKRLGIKIDIVKETDVETAYIYKHQ *" /label="yxnB CDS" gene 3715678..3716160 /gene="yxnB" /locus_tag="BSU_39910" /old_locus_tag="BSU39910" /label="yxnB gene" CDS 3716181..3718424 /gene="asnH" /locus_tag="BSU_39920" /old_locus_tag="BSU39920" /EC_number="6.3.5.4" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10498721, 17083466, 20185509" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10498721, 17083466, 20185509; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="asparagine synthetase (glutamine-hydrolyzing)" /protein_id="NP_391871.2" /db_xref="EnsemblGenomes-Gn:BSU39920" /db_xref="EnsemblGenomes-Tr:CAB16028" /db_xref="GOA:P42113" /db_xref="InterPro:IPR001962" /db_xref="InterPro:IPR006426" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR017932" /db_xref="InterPro:IPR029055" /db_xref="InterPro:IPR033738" /db_xref="SubtiList:BG11116" /db_xref="UniProtKB/Swiss-Prot:P42113" /translation="MCGLAGIINLAAPRSQECTFHILKGMADAISYRGPDDEQYHIDS KVGFAFRRLSILDLVNGQQPFLNEDGSIVVMVNGEIYNYKELKASLHNHMFKTTSDCE VIVHLYEEKGIGFVDDIIGMFSIAIWDKNKNKVFLVRDRFGIKPLFYTELKHELIFAS EIKSLFSHPHCPRQFNWKEALSDIWLSGEAASNHKETTSFFVNIQNLDAGHYLEINLT TNERKTASYWSLQDILLRQGYRENLHPDDLIEGYRELLADSVHRCLQSDVEVGLFLSG GIDSAAVAHFAAEKQDLHTFTVLSQSTFTNEDAKYAHWLAKDLHLPNHQVLYQLGNDE LLQPESYKHLLWICETPFCGPEQLYKFHLHKYAKAIRPNLKVMLTGQGSDEFNGGYST TLSPAENPSWEGFIESVNTMEMNRLHRLQGNIFRVWEEHFGLSPINLSYLKSNDSSQA DPWQSYVLTKYRDLQMYNCWHEDRIAAANHIENRVPFLDHRLVEWVCGIPDGLRKDLL WDKSVLRKSLTNELHTSYTHRPKVPFFYGKDVRYTHKMMFHLLKKNNYQLIEEAFSHS DASSIIQVEHIHAIMTYLEDDPEFTNFEFLLRLVNMGLLSKMTKETPSVQLDITSHLE SITIKDWHSQEGDIASRLNISANKCEGQDILALNPGVTLLRPESDSEHCIYIAEEGFI QFIVSEEDVGAWLHILCDINGKDTLHTILDRHGVSLEEVAKYIQEAIEHNIILIKQKN LPEGAYR*" /label="asnH CDS" gene 3716181..3718424 /gene="asnH" /locus_tag="BSU_39920" /old_locus_tag="BSU39920" /label="asnH gene" CDS 3718421..3719620 /gene="yxaM" /locus_tag="BSU_39930" /old_locus_tag="BSU39930" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15101989, 15849754, 16850406, 20185509; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_391872.2" /db_xref="EnsemblGenomes-Gn:BSU39930" /db_xref="EnsemblGenomes-Tr:CAB16029" /db_xref="GOA:P42112" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11115" /db_xref="UniProtKB/Swiss-Prot:P42112" /translation="MSIFYSFSALRGLAMGIFSPIWILYLISKDYDFLQIGLMGAVLE IAKLIFEVPSGVFADRYGIKISIASSFFFSILTWAFFPFIDSAAICILAMIIWALSDS LISGSFETWMSRVAGEDRFGKEMMKNTQLLITFLIIGSIASGYLYSLNIYFPFLLVMV IYLLLFIWMSVFIKVPSVSETNHGDQNQHDSIKIIKESLKIIFNKKRVLLIVIAGFFT ATAYDTISRYWQPFLSDLGFSEKSLGYIFALGGFTALVLLTLTIRFEKKIEKNPYLAL TSLDSMGMVMTFLLSRAFRPLGIPCTAFLLAIEDIHHPIVTSYLNKFFPDSYKNTLFS LNSGVGAIGEILSGVIFGIISAAFGLSAMFVVVAVFLLIPIILYTIVPKIKDNDMKVQ IEKSQQV*" /label="yxaM CDS" gene 3718421..3719620 /gene="yxaM" /locus_tag="BSU_39930" /old_locus_tag="BSU39930" /label="yxaM gene" promotor_-10 complement(3719376..3719394) /Source="Nicolas_upshift_promotors" /id="U3139" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=266 /SigmaFactorBS="aagaatttctccaattgctcctacccctgagtttaacgagaa aAGTGTGTtcttgtatgaatcgGGGAAAAACTTATTTAAGTaacttgttacgatcgga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3719398) /Source="Nicolas_upshifts" /id="U3139" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=266 /SigmaFactorBS="aagaatttctccaattgctcctacccctgagtttaacgagaa aAGTGTGTtcttgtatgaatcgGGGAAAAACTTATTTAAGTaacttgttacgatcgga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3719409..3719415) /Source="Nicolas_upshift_promotors" /id="U3139" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=266 /SigmaFactorBS="aagaatttctccaattgctcctacccctgagtttaacgagaa aAGTGTGTtcttgtatgaatcgGGGAAAAACTTATTTAAGTaacttgttacgatcgga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3719611 /Source="Nicolas_upshifts" /id="D2065" /incds=0 /nref=71 /ntot=174 /MaxReadThrough="3.22879" /MaxDrop="5.42242" /score="-6.94914943" /energy="-8.5" /TU="U3137" /idTUdmin="U3137" /TUdmin="-85" /isTUend="FALSE" /label="downshifts" downshifts complement(3719684) /Source="Nicolas_upshifts" /id="D2066" /incds=0 /nref=156 /ntot=227 /MaxReadThrough="3.53794" /MaxDrop="6.77896" /score="7.32872401" /energy="-16.9" /TU="U3140" /idTUdmin="U3141" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3719684..3720916) /gene="yxaL" /locus_tag="BSU_39940" /old_locus_tag="BSU39940" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12073041, 15743949, 17060472, 18165306, 22720735, 26060272; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="membrane associated protein kinase with beta-propeller domain" /protein_id="NP_391873.2" /db_xref="EnsemblGenomes-Gn:BSU39940" /db_xref="EnsemblGenomes-Tr:CAB16030" /db_xref="GOA:P42111" /db_xref="InterPro:IPR002372" /db_xref="InterPro:IPR011047" /db_xref="InterPro:IPR018391" /db_xref="SubtiList:BG11114" /db_xref="UniProtKB/Swiss-Prot:P42111" /translation="MVKSFRMKALIAGAAVAAAVSAGAVSDVPAAKVLQPTAAYAAET VFSQNNGASGFLPGRYDVQAMAPAMFNWSRESRFAGNTDGTLKWQNDIRTTPQNGAGA VIDGDGTVYLHSRDGEMKAFNPDGSVKWVTGNLGKTYTQSPVLGTNGVIYLASYDKKI YFIDKETGEILTTVPLSGGPSSETVIGSDGTLYFSTLDNYVHAIKPTSKSTWTERWKL KTNGVVSSVPVLAKNGTVYVGTYNYVFYAINSGTGQVKWSRTTSNAFKGYPVIDKDGN IYAGNQDGQLYAYTSTGSLKWTFPLNGFSSSSPAIDHNGNIYIGSGSGELFSISKNGD MNWSFYTDGPVRTAPLIDAKGTVYFGSDDMKVYAADANGNELWSYQTDSNVVSSPQLA EDGTLYIGSYTKLMAFGK*" /label="yxaL CDS" gene complement(3719684..3720916) /gene="yxaL" /locus_tag="BSU_39940" /old_locus_tag="BSU39940" /label="yxaL gene" promotor_-10 complement(3720948..3720967) /Source="Nicolas_upshift_promotors" /id="U3140" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.999000999001" /xcortree=1611 /SigmaFactorBS="atagttttctagtttgtgatgtttttgtgaaataGATTTAta aaatggatgaaTATGTTATGATGGTCACAAAttagaagttacatataatgggggtctc a" /listShort="yxaL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3720960) /Source="Nicolas_upshifts" /id="U3140" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.999000999001" /xcortree=1611 /SigmaFactorBS="atagttttctagtttgtgatgtttttgtgaaataGATTTAta aaatggatgaaTATGTTATGATGGTCACAAAttagaagttacatataatgggggtctc a" /listShort="yxaL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3720981..3720986) /Source="Nicolas_upshift_promotors" /id="U3140" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.999000999001" /xcortree=1611 /SigmaFactorBS="atagttttctagtttgtgatgtttttgtgaaataGATTTAta aaatggatgaaTATGTTATGATGGTCACAAAttagaagttacatataatgggggtctc a" /listShort="yxaL" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3721017..3721442) /gene="yxaJ" /locus_tag="BSU_39950" /old_locus_tag="BSU39950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15743949, 15849754, 16850406, 27902860; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein of unknown function" /protein_id="NP_391875.2" /db_xref="EnsemblGenomes-Gn:BSU39950" /db_xref="EnsemblGenomes-Tr:CAB16032" /db_xref="GOA:P42109" /db_xref="InterPro:IPR020204" /db_xref="SubtiList:BG11112" /db_xref="UniProtKB/Swiss-Prot:P42109" /translation="MSKKNSVAIMTTISAFLFCAVIVAASLSPLAGTGAAANQFNSAG MWSAVGMILVLYFIPFLVYMLGVDAMRYVMAVLCGFGLLIHLSSAGFILMFSFFSDHL LSEVIFVLGVSLAAAAVNVIWFVAAFRSGAEKTSVNTLT*" /label="yxaJ CDS" gene complement(3721017..3721442) /gene="yxaJ" /locus_tag="BSU_39950" /old_locus_tag="BSU39950" /label="yxaJ gene" promotor_-10 complement(3721470..3721489) /Source="Nicolas_upshift_promotors" /id="U3141" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.452547452547453" /psig=1 /xcortree=2293 /SigmaFactorBS="catttgtgtatgtattctggaattttttaaaaatatAATGAA TataacattcaacTTACTTATAATAAAAAAGGTtaatatttctattaaaggaggagtt t" /listShort="yxaJ, yxaL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3721484) /Source="Nicolas_upshifts" /id="U3141" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.452547452547453" /psig=1 /xcortree=2293 /SigmaFactorBS="catttgtgtatgtattctggaattttttaaaaatatAATGAA TataacattcaacTTACTTATAATAAAAAAGGTtaatatttctattaaaggaggagtt t" /listShort="yxaJ, yxaL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3721502..3721508) /Source="Nicolas_upshift_promotors" /id="U3141" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.452547452547453" /psig=1 /xcortree=2293 /SigmaFactorBS="catttgtgtatgtattctggaattttttaaaaatatAATGAA TataacattcaacTTACTTATAATAAAAAAGGTtaatatttctattaaaggaggagtt t" /listShort="yxaJ, yxaL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3721634..3721641 /Source="Nicolas_upshift_promotors" /id="U3142" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.526473526473527" /psig="0.995004995004995" /xcortree=2320 /SigmaFactorBS="aagactcatttttctgtaatatcaggattttatcaccatacc aTATTGCATgtacatgtttttcaAAGTATACTATTCCAGATTAattcagaggagagag a" /listShort="yxaI, S1535" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3721651 /Source="Nicolas_upshifts" /id="U3142" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.526473526473527" /psig="0.995004995004995" /xcortree=2320 /SigmaFactorBS="aagactcatttttctgtaatatcaggattttatcaccatacc aTATTGCATgtacatgtttttcaAAGTATACTATTCCAGATTAattcagaggagagag a" /listShort="yxaI, S1535" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3721656..3721675 /Source="Nicolas_upshift_promotors" /id="U3142" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.526473526473527" /psig="0.995004995004995" /xcortree=2320 /SigmaFactorBS="aagactcatttttctgtaatatcaggattttatcaccatacc aTATTGCATgtacatgtttttcaAAGTATACTATTCCAGATTAattcagaggagagag a" /listShort="yxaI, S1535" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3721699..3722154 /gene="yxaI" /locus_tag="BSU_39960" /old_locus_tag="BSU39960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein of unknown function" /protein_id="NP_391876.1" /db_xref="EnsemblGenomes-Gn:BSU39960" /db_xref="EnsemblGenomes-Tr:CAB16033" /db_xref="GOA:P42108" /db_xref="InterPro:IPR010432" /db_xref="SubtiList:BG11111" /db_xref="UniProtKB/Swiss-Prot:P42108" /translation="MEKPAGFWIRFLAYFIDGIIVSVPSYIILFIINSVFVAGAVATN PYMTEEEYLVKYMTLAFLPTMLIMIVISVLYYGLLTASKMQGTLGKKILGLKVVNEQG ERVSVGQGIGRYFAYILSGIIFYIGFIMIAFGEKKGLHDIICKTRVVYK*" /label="yxaI CDS" gene 3721699..3722154 /gene="yxaI" /locus_tag="BSU_39960" /old_locus_tag="BSU39960" /label="yxaI gene" downshifts 3722092 /Source="Nicolas_upshifts" /id="D2067" /incds=1 /nref=58 /ntot=234 /MaxReadThrough="3.24719" /MaxDrop="5.4441" /score="18.1083522" /energy="-13.4" /TU="U3142" /idTUdmin="U3142" /TUdmin="-637" /isTUend="FALSE" /label="downshifts" S_feature 3722155..3722768 /Source="Nicolas_S_feature" /locus_tag="new_4104900_4105513" /HighExp="LPh, HPh, MG 60, BMM, MG t5, G180, MG 45, G150, MG-0.2, MG 10" /AntisenseName="yxaH" /AntisenseCor="0.37646026982403002" /AntisenseRegPval="-9.8000000000000007" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S1535" CDS complement(3722184..3723392) /gene="yxaH" /locus_tag="BSU_39970" /old_locus_tag="BSU39970" /experiment="publication(s) with functional evidences, PMID:15317768, 15849754, 16850406, 21737930" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15317768, 15849754, 16850406, 21737930; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="integral inner membrane protein involved in response to flavonoids" /protein_id="NP_391877.2" /db_xref="EnsemblGenomes-Gn:BSU39970" /db_xref="EnsemblGenomes-Tr:CAB16034" /db_xref="GOA:P42107" /db_xref="InterPro:IPR007349" /db_xref="SubtiList:BG11110" /db_xref="UniProtKB/Swiss-Prot:P42107" /translation="MSSLQPTLTNERIGVLDVLRGMAIFGILFVNLAHFSYPDMYLSM LGKENFFMDKWSEADFAAADILKFFIQTKCILLFSFLFGFGMVVMMERAENKGKRFVP LYVRRLMALLLFGTIHAFLIWDGDILTEYALLGFVLLLFRKAKPKTLLIWAVSLYLLF SIPFMLTSFDQSNGQEWVQAVTQQAKQAIHVYGSGSLKDIAEQRIHDRLVYMSSNGML TYNPLNYFFASIPYFSMFLLGAAAAKSRYLHEPEKHRKGLKRLWMAGLVIGIGAQVLY SVTDKEICLLIGAPFLMFFYVTTVVYLYHKTRVRTVLQSFSAVGRMAFTNYLMQSIVC TWIFYHYGLGLYGKVYPAAGVLITIAVCAVQMVFSHLWLRVFRMGPFEWLWRSATYLS WQPIAKKTKV*" /label="yxaH CDS" gene complement(3722184..3723392) /gene="yxaH" /locus_tag="BSU_39970" /old_locus_tag="BSU39970" /label="yxaH gene" downshifts complement(3722211) /Source="Nicolas_upshifts" /id="D2068" /incds=0 /nref=14 /ntot=66 /MaxReadThrough="0.30987" /MaxDrop="3.782" /score="34.1593124" /energy="-16.2" /TU="NA" /idTUdmin="U3143" /TUdmin=286 /isTUend="FALSE" /label="downshifts" S_feature complement(3723393..3723499) /Source="Nicolas_S_feature" /locus_tag="new_4106138_4106244_c" /HighExp="T-5.40H, T-4.40H, SMMPr, T-2.40H, T-3.40H, T-1.40H, Sw, T0.0H, Pyr, T-0.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S1536" CDS complement(3723500..3724513) /gene="qdoI" /locus_tag="BSU_39980" /old_locus_tag="BSU39980" /EC_number="1.13.11.24" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14697267, 15317768, 15628860, 17483215, 14741339, 15039076, 20460727, 21737930" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14697267, 15317768, 15628860, 17483215, 14741339, 15039076, 20460727, 21737930; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="quercetin dioxygenase" /protein_id="NP_391878.2" /db_xref="EnsemblGenomes-Gn:BSU39980" /db_xref="EnsemblGenomes-Tr:CAB16035" /db_xref="GOA:P42106" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR013096" /db_xref="InterPro:IPR014710" /db_xref="PDB:1Y3T" /db_xref="PDB:2H0V" /db_xref="SubtiList:BG11109" /db_xref="UniProtKB/Swiss-Prot:P42106" /translation="MKTLCTHSLPKEKMPYLLRSGEGERYLFGRQVATVMANGRSTGD LFEIVLLSGGKGDAFPLHVHKDTHEGILVLDGKLELTLDGERYLLISGDYANIPAGTP HSYRMQSHRTRLVSYTMKGNVAHLYSVIGNPYDHAEHPPYASEEVSNERFAEAAAVAD IVFLDEAKPACSAKLAELTELPDGAVPYVLESGEGDRLLTGDQLHRIVAAQKNTDGQF IVVSSEGPKGDRIVDHYHEYHTETFYCLEGQMTMWTDGQEIQLNPGDFLHVPANTVHS YRLDSHYTKMVGVLVPGLFEPFFRTLGDPYEGHIFPCEPQALRFDRILQNIEALDLKV MKP*" /label="qdoI CDS" gene complement(3723500..3724513) /gene="qdoI" /locus_tag="BSU_39980" /old_locus_tag="BSU39980" /label="qdoI gene" S_feature complement(3724514..3724587) /Source="Nicolas_S_feature" /locus_tag="new_4107259_4107332_c" /HighExp="T-3.40H, T-5.40H, T-1.40H, T-2.40H, T-4.40H, T-0.40H, T0.0H, Pyr, SMMPr, GM-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S1537" promotor_-10 complement(3724572..3724591) /Source="Nicolas_upshift_promotors" /id="U3143" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.622377622377622" /psig="0.995004995004995" /xcortree=2866 /SigmaFactorBS="ttgccgaacaaataccagtgctggtgagaaaaaaagGGTAGC ATtttgttatccttTCTCCTACAATTATATAGAAcggtctagacaaatgaatgataat a" /listShort="S1537, qodI, S1536, yxaH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3724587) /Source="Nicolas_upshifts" /id="U3143" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.622377622377622" /psig="0.995004995004995" /xcortree=2866 /SigmaFactorBS="ttgccgaacaaataccagtgctggtgagaaaaaaagGGTAGC ATtttgttatccttTCTCCTACAATTATATAGAAcggtctagacaaatgaatgataat a" /listShort="S1537, qodI, S1536, yxaH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3724604..3724611) /Source="Nicolas_upshift_promotors" /id="U3143" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.622377622377622" /psig="0.995004995004995" /xcortree=2866 /SigmaFactorBS="ttgccgaacaaataccagtgctggtgagaaaaaaagGGTAGC ATtttgttatccttTCTCCTACAATTATATAGAAcggtctagacaaatgaatgataat a" /listShort="S1537, qodI, S1536, yxaH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3724607..3725182) /gene="qdoR" /locus_tag="BSU_39990" /old_locus_tag="BSU39990" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17483215, 21737930" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17483215, 21737930; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of qdoI" /protein_id="NP_391879.2" /db_xref="EnsemblGenomes-Gn:BSU39990" /db_xref="EnsemblGenomes-Tr:CAB16036" /db_xref="GOA:P42105" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="PDB:1SGM" /db_xref="SubtiList:BG11108" /db_xref="UniProtKB/Swiss-Prot:P42105" /translation="MTSRGDSREKILHTASRLFQLQGYHATGLNQIVKESGAPKGSLY HFFPNGKEELAIEAVTYTGKIVEHLIQQSMDESSDPVEAIQLFIKKTASQFDNTESIK GIPVGLLASETALISEPLRTVCMKVFKSWEAVFARKLMENGFAEEEANQLGTLINSMI EGGIMLSLTNKDKTPLLLIAEQIPVLVRKKG*" /label="qdoR CDS" gene complement(3724607..3725182) /gene="qdoR" /locus_tag="BSU_39990" /old_locus_tag="BSU39990" /label="qdoR gene" downshifts complement(3724631) /Source="Nicolas_upshifts" /id="D2069" /incds=0 /nref=1 /ntot=19 /MaxReadThrough="1.66581" /MaxDrop="2.62803" /score="-2.51956315" /energy="-8.8" /TU="NA" /idTUdmin="U3144" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3725211..3725230) /Source="Nicolas_upshift_promotors" /id="U3144" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85914085914086" /psig="0.999000999001" /xcortree=2479 /SigmaFactorBS="tgtacattaccccatccggaagggtcttaccccTTTTGACAa tcacagggttcttTTTTATATTATATAAGTCGCtctaccatacctaggagggaatgtt t" /listShort="yxaF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3725225) /Source="Nicolas_upshifts" /id="U3144" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85914085914086" /psig="0.999000999001" /xcortree=2479 /SigmaFactorBS="tgtacattaccccatccggaagggtcttaccccTTTTGACAa tcacagggttcttTTTTATATTATATAAGTCGCtctaccatacctaggagggaatgtt t" /listShort="yxaF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3725245..3725252) /Source="Nicolas_upshift_promotors" /id="U3144" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85914085914086" /psig="0.999000999001" /xcortree=2479 /SigmaFactorBS="tgtacattaccccatccggaagggtcttaccccTTTTGACAa tcacagggttcttTTTTATATTATATAAGTCGCtctaccatacctaggagggaatgtt t" /listShort="yxaF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3725253..3725259 /Source="Nicolas_upshift_promotors" /id="U3145" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=252 /SigmaFactorBS="taatataaaaaagaaccctgtgattgtcaaaaGGGGTAAgac ccttccggatgGGGTAATGTACAAAAACAGcgtctaggagggatctctcaatgacaat c" /listShort="yxnA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3725274..3725292 /Source="Nicolas_upshift_promotors" /id="U3145" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=252 /SigmaFactorBS="taatataaaaaagaaccctgtgattgtcaaaaGGGGTAAgac ccttccggatgGGGTAATGTACAAAAACAGcgtctaggagggatctctcaatgacaat c" /listShort="yxnA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3725281 /Source="Nicolas_upshifts" /id="U3145" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=252 /SigmaFactorBS="taatataaaaaagaaccctgtgattgtcaaaaGGGGTAAgac ccttccggatgGGGTAATGTACAAAAACAGcgtctaggagggatctctcaatgacaat c" /listShort="yxnA" /GFF_Attribute="listLong" /label="upshifts" CDS 3725313..3726383 /gene="yxnA" /locus_tag="BSU_40000" /old_locus_tag="BSU40000" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391880.2" /db_xref="EnsemblGenomes-Gn:BSU40000" /db_xref="EnsemblGenomes-Tr:CAB16037" /db_xref="GOA:O32291" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG14165" /db_xref="UniProtKB/Swiss-Prot:O32291" /translation="MTIDHSVTNTEQLEQQNPAIKTKLKLKKLKDQVIVITGASSGIG LVTARMAAEKGAKVVAAARNEEALKELTDELKEKGHDAIWVKADVGKEEDVNRIAETA ISTFGRFDTWVNNAAVSTFGHAMDVTVEDMKRMFDTNFWGPVYGTRAAVKHYTGRGVP GALINVGSLFGDRGTVIQSTYASAKFALHGWTESIRMELEKEQAPVSVTLIHPGRIDT PYNEHAHSYLDKQPAHYRSMIYPPEAVAEAILFAAEHPKRDMYIGSQAKAIAMLGALF PRLTDRLMEKIMYHSQHAERPSNPREESALYDAGCGMHDRGTNKGWMRSRSYYTKATK RPIVSAAVVAGLVAWAAAKRCR*" /label="yxnA CDS" gene 3725313..3726383 /gene="yxnA" /locus_tag="BSU_40000" /old_locus_tag="BSU40000" /label="yxnA gene" downshifts 3726381 /Source="Nicolas_upshifts" /id="D2070" /incds=0 /nref=7 /ntot=44 /MaxReadThrough="2.68466" /MaxDrop="3.96227" /score="-3.48213422" /energy="-11.2" /TU="NA" /idTUdmin="U3145" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3726440..3726871) /gene="yxaD" /locus_tag="BSU_40010" /old_locus_tag="BSU40010" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)" /protein_id="NP_391881.1" /db_xref="EnsemblGenomes-Gn:BSU40010" /db_xref="EnsemblGenomes-Tr:CAB16038" /db_xref="GOA:P42103" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11106" /db_xref="UniProtKB/Swiss-Prot:P42103" /translation="MQNQNPVELIEYELTTFIRRAVYLDQSEKRTGNLERSSYLLLRQ LDEFGPARVKELAESFKLDISTLSRQAAALEAKELIYRFSDPSDGRVSLFTITKLGKQ LLKADQQKRLERYEQMLKEWSTQEKEMFGELLQRMNKAFID*" /label="yxaD CDS" gene complement(3726440..3726871) /gene="yxaD" /locus_tag="BSU_40010" /old_locus_tag="BSU40010" /label="yxaD gene" promotor_-35 3726901..3726908 /Source="Nicolas_upshift_promotors" /id="U3146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2436 /SigmaFactorBS="atcgctctcgctccctattccaatctccggCATTGACAacat catatatacTTGTATAATACAAATGTACAttaactgaataaatacaagtcgttatatg a" /listShort="S1538, yxzK, yxaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3726922..3726941 /Source="Nicolas_upshift_promotors" /id="U3146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2436 /SigmaFactorBS="atcgctctcgctccctattccaatctccggCATTGACAacat catatatacTTGTATAATACAAATGTACAttaactgaataaatacaagtcgttatatg a" /listShort="S1538, yxzK, yxaC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3726931..3727097 /Source="Nicolas_S_feature" /locus_tag="new_4109676_4109842" /HighExp="LBGstat, Cold, Heat, Salt, Etha, H2O2, G180, LBGtran, GM 150, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1538" upshifts 3726931 /Source="Nicolas_upshifts" /id="U3146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2436 /SigmaFactorBS="atcgctctcgctccctattccaatctccggCATTGACAacat catatatacTTGTATAATACAAATGTACAttaactgaataaatacaagtcgttatatg a" /listShort="S1538, yxzK, yxaC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3726983..3727002) /Source="Nicolas_upshift_promotors" /id="U3147" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85014985014985" /psig="0.999000999001" /xcortree=2442 /SigmaFactorBS="cctttctggtgcttgcttctaggatggttctgaggaatcGCT TTACTttctttttatatgaTTGTACTATACAAGTATAATaattgatttagtcatataa c" /listShort="yxaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3727003) /Source="Nicolas_upshifts" /id="U3147" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85014985014985" /psig="0.999000999001" /xcortree=2442 /SigmaFactorBS="cctttctggtgcttgcttctaggatggttctgaggaatcGCT TTACTttctttttatatgaTTGTACTATACAAGTATAATaattgatttagtcatataa c" /listShort="yxaD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3727017..3727024) /Source="Nicolas_upshift_promotors" /id="U3147" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85014985014985" /psig="0.999000999001" /xcortree=2442 /SigmaFactorBS="cctttctggtgcttgcttctaggatggttctgaggaatcGCT TTACTttctttttatatgaTTGTACTATACAAGTATAATaattgatttagtcatataa c" /listShort="yxaD" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3727098..3727502 /gene="yxzK" /locus_tag="BSU_40021" /old_locus_tag="BSU40021" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein involved in export murein hydrolases" /protein_id="YP_003097798.1" /db_xref="EnsemblGenomes-Gn:BSU40021" /db_xref="EnsemblGenomes-Tr:CAX52713" /db_xref="GOA:C0H3T7" /db_xref="InterPro:IPR005538" /db_xref="InterPro:IPR036640" /db_xref="UniProtKB/Swiss-Prot:C0H3T7" /translation="MKVIRIILQVLILYVFFMIGEAIQHLFHLPVSGSIVGLVLLLIC LGLRIVPVSIIEDGAGFLLSFLPLLFIPAMTGVINYPSLISFNGLMLLITVVLSTIVT IIAAGFASQLLEKKAKKREEKEKCSKHVSRSL*" /label="yxzK CDS" gene 3727098..3727502 /gene="yxzK" /locus_tag="BSU_40021" /old_locus_tag="BSU40021" /label="yxzK gene" S_feature complement(3727119..3728171) /Source="Nicolas_S_feature" /locus_tag="new_4109864_4110916_c" /HighExp="Etha, C30, H2O2, Salt, Paraq, GM 120, Diami, Oxctl, G180, Sw" /AntisenseName="yxaC" /AntisenseCor="0.145103505386703" /AntisenseRegPval="-1.8" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S1539" CDS 3727472..3728164 /gene="yxaC" /locus_tag="BSU_40022" /old_locus_tag="BSU40022" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15126464, 15849754, 16850406, 17452642, 26060272; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative murein hydrolase export regulator" /protein_id="NP_391882.3" /db_xref="EnsemblGenomes-Gn:BSU40022" /db_xref="EnsemblGenomes-Tr:CAB16039" /db_xref="GOA:P42102" /db_xref="InterPro:IPR007300" /db_xref="SubtiList:BG11105" /db_xref="UniProtKB/Swiss-Prot:P42102" /translation="MQQACIAIIIILLTVAAYLAMVKLYKRFPLPFLIPVLTTTILIV AALMMFHVSYEGYMIGGKWINSLLGPAVVALAYPLYKQWHIIVKHCVPILGGVLVGLC MGMISGLIFAEAFGIDHDLLLSILPKSITTPVAIQIAAGLGGVPSMTVVFVMIAGFSG VILGPLFLKWLRIRSSLGQGIALGSASHALGTSKALEYGELAVSMSSVSMTLCAVLGS FFGPLVVWLFHI*" /label="yxaC CDS" gene 3727472..3728164 /gene="yxaC" /locus_tag="BSU_40022" /old_locus_tag="BSU40022" /label="yxaC gene" CDS complement(3728204..3729235) /gene="yxaB" /locus_tag="BSU_40030" /old_locus_tag="BSU40030" /EC_number="2.-.-.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9298659, 18326573; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative exopolysaccharide pyruvyl transferase (biofilm formation)" /protein_id="NP_391883.3" /db_xref="EnsemblGenomes-Gn:BSU40030" /db_xref="EnsemblGenomes-Tr:CAB16040" /db_xref="GOA:P42101" /db_xref="InterPro:IPR007345" /db_xref="SubtiList:BG11104" /db_xref="UniProtKB/Swiss-Prot:P42101" /translation="MTVQEIKGKKLVKGIAPNVEPEALLNDKRKVFLFGSPSYTNIGD QAIAYAEEKFIKNHFPYYEYIEIMDYATDEGIELVKEIIREDDIVCFTGGGNLGNLYL DIEEDRRKVFSAFKDYKSISLPQSVYFEDTEEGQKEKKKTQDAYHQNTNLTIAARETQ TLDVVKETFNSNVIFTPDMVLSLDIVPRELERDGVLFILRADKEKVTDEDFISQMKQW AEKTTYTERTDTVLDTVDTIDYADREKHFMEMLDRIGSSKLVITDRLHAMIFSIITKT PCLVFGNSYGKAKHSYRDWLESLNFIEYTDKNDVEELERMIDRLLQAEPNDVDLSKDF QPLIDFFAS*" /label="yxaB CDS" gene complement(3728204..3729235) /gene="yxaB" /locus_tag="BSU_40030" /old_locus_tag="BSU40030" /label="yxaB gene" downshifts complement(3728216) /Source="Nicolas_upshifts" /id="D2071" /incds=0 /nref=5 /ntot=94 /MaxReadThrough="6.52386" /MaxDrop="4.6522" /score="17.8326496" /energy="-15.3" /TU="U3149" /idTUdmin="U3150" /TUdmin=220 /isTUend="FALSE" /label="downshifts" promotor_-35 3729202..3729205 /Source="Nicolas_upshift_promotors" /id="U3148" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.618381618381618" /psig="0.996003996003996" /xcortree=1822 /SigmaFactorBS="atttaacagagcttccggctccacatttggcgcaatgccttt taCTAGttttttgcctttgattTCTTGTACAGTCATATCTGCgtcctccttctgggat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3729218 /Source="Nicolas_upshifts" /id="U3148" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.618381618381618" /psig="0.996003996003996" /xcortree=1822 /SigmaFactorBS="atttaacagagcttccggctccacatttggcgcaatgccttt taCTAGttttttgcctttgattTCTTGTACAGTCATATCTGCgtcctccttctgggat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3729222..3729241 /Source="Nicolas_upshift_promotors" /id="U3148" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.618381618381618" /psig="0.996003996003996" /xcortree=1822 /SigmaFactorBS="atttaacagagcttccggctccacatttggcgcaatgccttt taCTAGttttttgcctttgattTCTTGTACAGTCATATCTGCgtcctccttctgggat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(3729272..3729290) /Source="Nicolas_upshift_promotors" /id="U3149" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=258 /SigmaFactorBS="cgaaaacgatgtttctgatatagccgatgcacatgccaaTGC ATAGccatccttctttttGGGTAGAGACAGTTAACACacaatgaggaattcatcccag a" /listShort="yxaB, S1539" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3729290) /Source="Nicolas_upshifts" /id="U3149" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=258 /SigmaFactorBS="cgaaaacgatgtttctgatatagccgatgcacatgccaaTGC ATAGccatccttctttttGGGTAGAGACAGTTAACACacaatgaggaattcatcccag a" /listShort="yxaB, S1539" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3729305..3729311) /Source="Nicolas_upshift_promotors" /id="U3149" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=258 /SigmaFactorBS="cgaaaacgatgtttctgatatagccgatgcacatgccaaTGC ATAGccatccttctttttGGGTAGAGACAGTTAACACacaatgaggaattcatcccag a" /listShort="yxaB, S1539" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3729328..3730476) /gene="glxK" /locus_tag="BSU_40040" /old_locus_tag="BSU40040" /EC_number="2.7.1.31" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15771780, 18326573; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-glycerate kinase" /protein_id="NP_391884.2" /db_xref="EnsemblGenomes-Gn:BSU40040" /db_xref="EnsemblGenomes-Tr:CAB16041" /db_xref="GOA:P42100" /db_xref="InterPro:IPR004381" /db_xref="InterPro:IPR018193" /db_xref="InterPro:IPR036129" /db_xref="SubtiList:BG11103" /db_xref="UniProtKB/Swiss-Prot:P42100" /translation="MKIIIAPDSFKESLSALEAAEAIERGFKSVFPGADYRKLPVADG GEGTVQSLVDATNGRIIEQVVTGPLGEPVRAFFGMMGDGRTAVIEMAAASGLHLVPVD KRNPLITTTRGTGELIGAALDAGAERLIIGIGGSATNDGGAGMIQALGGRLLDNSGSE IGPGGGALSQLASIDVSGLDSRLRNVKLEVACDVDNPLTGPKGATAVFGPQKGATADM LDVLDQNVSHFADMAEKALGSTFRDTEGAGAAGGLGWSLLTYLQADLKRGIDIVLEAV DFESIVQDADLVITGEGRIDSQTVHGKTPIGVAKAAKSYDVPVIGIAGSISRDSNAVY QHGIDALFSIVPGAVPLEDAFEHAAEYMERTARDIAASIKLAKTMFLI*" /label="glxK CDS" gene complement(3729328..3730476) /gene="glxK" /locus_tag="BSU_40040" /old_locus_tag="BSU40040" /label="glxK gene" promotor_-10 complement(3730515..3730534) /Source="Nicolas_upshift_promotors" /id="U3150" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=3162 /SigmaFactorBS="aatttttatttaaatttttaccatattgcatggtATGTATTT ccagatcaatTATGGTACATTGGAGATCAAtaggttaagtgaatcatgttttgaaaga g" /listShort="glxK, yxaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3730526) /Source="Nicolas_upshifts" /id="U3150" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=3162 /SigmaFactorBS="aatttttatttaaatttttaccatattgcatggtATGTATTT ccagatcaatTATGGTACATTGGAGATCAAtaggttaagtgaatcatgttttgaaaga g" /listShort="glxK, yxaB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3730545..3730552) /Source="Nicolas_upshift_promotors" /id="U3150" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=3162 /SigmaFactorBS="aatttttatttaaatttttaccatattgcatggtATGTATTT ccagatcaatTATGGTACATTGGAGATCAAtaggttaagtgaatcatgttttgaaaga g" /listShort="glxK, yxaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3730598..3730605 /Source="Nicolas_upshift_promotors" /id="U3151" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=1787 /SigmaFactorBS="gtaaaaatttaaataaaaattagaaatgaaagTGTTTGCAta aaagaaatattCACGTTATCATACTTGTATAcaagtatactccttgagtgaggaaggt g" /listShort="gntR, gntK, gntP, gntZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3730619..3730638 /Source="Nicolas_upshift_promotors" /id="U3151" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=1787 /SigmaFactorBS="gtaaaaatttaaataaaaattagaaatgaaagTGTTTGCAta aaagaaatattCACGTTATCATACTTGTATAcaagtatactccttgagtgaggaaggt g" /listShort="gntR, gntK, gntP, gntZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3730626 /Source="Nicolas_upshifts" /id="U3151" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=1787 /SigmaFactorBS="gtaaaaatttaaataaaaattagaaatgaaagTGTTTGCAta aaagaaatattCACGTTATCATACTTGTATAcaagtatactccttgagtgaggaaggt g" /listShort="gntR, gntK, gntP, gntZ" /GFF_Attribute="listLong" /label="upshifts" CDS 3730672..3731403 /gene="gntR" /locus_tag="BSU_40050" /old_locus_tag="BSU40050" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7476858, 7642511, 8655507, 9106211, 26151451" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7476858, 7642511, 8655507, 9106211, 26151451; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (GntR-gluconate)" /protein_id="NP_391885.1" /db_xref="EnsemblGenomes-Gn:BSU40050" /db_xref="EnsemblGenomes-Tr:CAB16042" /db_xref="GOA:P10585" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR008920" /db_xref="InterPro:IPR011711" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10648" /db_xref="UniProtKB/Swiss-Prot:P10585" /translation="MLDSKDLLYPAKWLSKASTGVRVAYELRMRIVSGLIESGTILSE NTIAAEFSVSRSPVREALKILASEKIIRLERMGAVVIGLTEKKIAEIYDVRLLLETFV FERLVKIDIEPLVKDLSKILEMMKVSIKYEDADEFSFQDVLFHETIIRAIDHSYIQMI WNNLKPVMESFILLSMRVRLKEKYEDFTRILDNHELYIQAIKTKDRALMIQSLHQNFD DVQDKVEDLWLSQQMLAKGAEYNND*" /label="gntR CDS" gene 3730672..3731403 /gene="gntR" /locus_tag="BSU_40050" /old_locus_tag="BSU40050" /label="gntR gene" CDS 3731396..3732937 /gene="gntK" /locus_tag="BSU_40060" /old_locus_tag="BSU40060" /EC_number="2.7.1.12" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1659648, 2537826, 3020045, 11468405" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1659648, 2537826, 3020045, 11468405; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-gluconate kinase" /protein_id="NP_391886.1" /db_xref="EnsemblGenomes-Gn:BSU40060" /db_xref="EnsemblGenomes-Tr:CAB16043" /db_xref="GOA:P12011" /db_xref="InterPro:IPR000577" /db_xref="InterPro:IPR006002" /db_xref="InterPro:IPR018483" /db_xref="InterPro:IPR018484" /db_xref="InterPro:IPR018485" /db_xref="SubtiList:BG10649" /db_xref="UniProtKB/Swiss-Prot:P12011" /translation="MTSYMLGIDIGTTSTKAVLFSENGDVVQKESIGYPLYTPDISTA EQNPEEIFQAVIHTTARITKQHPEKRISFISFSSAMHSVIAIDENDKPLTPCITWADN RSEGWAHKIKEELNGHEVYKRTGTPIHPMAPLSKIAWITNERKEIASKAKKYIGIKEY IFKQLFNEYVIDYSLASATGMMNLKGLDWDEEALRIAGITPDHLSKLVPTTEIFQHCS PEIAIQMGIDPETPFVIGASDGVLSNLGVNAIKKGEIAVTIGTSGAIRTIIDKPQTDE KGRIFCYALTDKHWVIGGPVNNGGIVLRWIRDEFASSEIETATRLGIDPYDVLTKIAQ RVRPGSDGLLFHPYLAGERAPLWNPDVRGSFFGLTMSHKKEHMIRAALEGVIYNLYTV FLALTECMDGPVTRIQATGGFARSEVWRQMMSDIFESEVVVPESYESSCLGACILGLY ATGKIDSFDAVSDMIGSTYRHTPIEDSAKEYRTLMPIFINLSRLLENQYTQIADYQRG LITHK*" /label="gntK CDS" gene 3731396..3732937 /gene="gntK" /locus_tag="BSU_40060" /old_locus_tag="BSU40060" /label="gntK gene" CDS 3732966..3734312 /gene="gntP" /locus_tag="BSU_40070" /old_locus_tag="BSU40070" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:3020045, 15849754, 1659648, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3020045, 15849754, 1659648, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="gluconate/proton permease" /protein_id="NP_391887.1" /db_xref="EnsemblGenomes-Gn:BSU40070" /db_xref="EnsemblGenomes-Tr:CAB16044" /db_xref="GOA:P12012" /db_xref="InterPro:IPR003474" /db_xref="SubtiList:BG10650" /db_xref="UniProtKB/Swiss-Prot:P12012" /translation="MPLIIVALGILALLFLIMGLKLNTFISLLVVSFGVALALGMPFD KVVSSIEAGIGGTLGHIALIFGLGAMLGKLIADSGGAQRIAMTLVNKFGEKNIQWAVV IASFIIGIALFFEVGLVLLIPIVFAISRELKISILFLGIPMVAALSVTHGFLPPHPGP TAIAGEYGANIGEVLLYGFIVAVPTVLIAGPLFTKFAKKIVPASFAKNGNIASLGTQK TFNLEETPGFGISVFTAMLPIIIMSVATIIDLLQETIGFADNGVLAFIRLIGNASTAM IISLLVAVYTMGIKRNIPVKTVMDSCSTAISQIGMMLLIIGGGGAFKQVLINGGVGDY VADLFKGTALSPIILAWLIAAILRISLGSATVAALSTTGLVIPLLGHSDVNLALVVLA TGAGSVIASHVNDAGFWMFKEYFGLSMKETFATWTLLETIISVAGLGFILLLSLVV*" /label="gntP CDS" gene 3732966..3734312 /gene="gntP" /locus_tag="BSU_40070" /old_locus_tag="BSU40070" /label="gntP gene" promotor_-35 3733765..3733769 /Source="Nicolas_upshift_promotors" /id="U3152" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.801198801198801" /psig="0.998001998001998" /xcortree=2695 /SigmaFactorBS="tttgcagataacggagttttagcttttatcaGATTGattgga aacgcatcgACTGCTATGATTATTTCGTTattggtcgcagtctatacaatgggcatca a" /listShort="gntZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3733785..3733804 /Source="Nicolas_upshift_promotors" /id="U3152" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.801198801198801" /psig="0.998001998001998" /xcortree=2695 /SigmaFactorBS="tttgcagataacggagttttagcttttatcaGATTGattgga aacgcatcgACTGCTATGATTATTTCGTTattggtcgcagtctatacaatgggcatca a" /listShort="gntZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3733794 /Source="Nicolas_upshifts" /id="U3152" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.801198801198801" /psig="0.998001998001998" /xcortree=2695 /SigmaFactorBS="tttgcagataacggagttttagcttttatcaGATTGattgga aacgcatcgACTGCTATGATTATTTCGTTattggtcgcagtctatacaatgggcatca a" /listShort="gntZ" /GFF_Attribute="listLong" /label="upshifts" CDS 3734335..3735741 /gene="gntZ" /locus_tag="BSU_40080" /old_locus_tag="BSU40080" /EC_number="1.1.1.343" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15231785, 9535092, 9931298" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15231785, 9535092, 9931298; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="6-phosphogluconate dehydrogenase (NAD+-dependent)" /protein_id="NP_391888.1" /db_xref="EnsemblGenomes-Gn:BSU40080" /db_xref="EnsemblGenomes-Tr:CAB16045" /db_xref="GOA:P12013" /db_xref="InterPro:IPR006113" /db_xref="InterPro:IPR006114" /db_xref="InterPro:IPR006115" /db_xref="InterPro:IPR006183" /db_xref="InterPro:IPR006184" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10651" /db_xref="UniProtKB/Swiss-Prot:P12013" /translation="MFNSIGVIGLGVMGSNIALNMANKGENVAVYNYTRDLTDQLIQK LDGQSLSPYYELEDFVQSLEKPRKIFLMVTAGKPVDSVIQSLKPLLEEGDVIMDGGNS HYEDTERRYDELKEKGIGYLGVGISGGEVGALTGPSIMPGGDRDVYEKAAPILTKIAA QVGDDPCCVYIGPKGAGHFTKMVHNGIEYADMQLIAEAYTFLRETLRLPLDEIASIFE TWNQGELKSYLIEITAEILRKKDEKTGQPLIDVILDKTGQKGTGKWTSMQAIDNGIPS TIITESLFARYLSSLKEERMAAQDVLAGPEAEEKHLDKDTWIEYVRQALYMGKVCAYA QGFAQYKMSSELYGWNLPLKDIALIFRGGCIIRADFLNVISEAFSEQPNLANLLIAPY FTDKLHAYQTGLRKVVCEGISTGISFPCLTTALSYYDGYRTGRSNANLLQAQRDYFGA HTYERTDMDGVFHTNWSE*" /label="gntZ CDS" gene 3734335..3735741 /gene="gntZ" /locus_tag="BSU_40080" /old_locus_tag="BSU40080" /label="gntZ gene" downshifts 3735730 /Source="Nicolas_upshifts" /id="D2072" /incds=0 /nref=128 /ntot=228 /MaxReadThrough="3.81668" /MaxDrop="5.52642" /score="20.2280166" /energy="-10.2" /TU="NA" /idTUdmin="U3151" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature 3735838..3735857 /Source="Nicolas_upshift_promotors" /id="U3153" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.898101898101898" /psig=1 /xcortree=620 /SigmaFactorBS="tttttttcttctatcccaaacaacagaagacataagttatgt tttaaatatcataaacAGTGATACAATAATAGCTAGaaacaatccccaagatcatcat g" /listShort="S1540" /listLong="ahpC, ahpF" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 3735840..3736131 /Source="Nicolas_S_feature" /locus_tag="new_4118585_4118876" /HighExp="S8, Etha, Sw, T0.30H, Cold, H2O2, B60, S5, S4, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1540" upshifts 3735840 /Source="Nicolas_upshifts" /id="U3153" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.898101898101898" /psig=1 /xcortree=620 /SigmaFactorBS="tttttttcttctatcccaaacaacagaagacataagttatgt tttaaatatcataaacAGTGATACAATAATAGCTAGaaacaatccccaagatcatcat g" /listShort="S1540" /listLong="ahpC, ahpF" /label="upshifts" promotor_-35 3736104..3736111 /Source="Nicolas_upshift_promotors" /id="U3154" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.532467532467532" /psig=1 /xcortree=2087 /SigmaFactorBS="cctttattaagatgaaaaaaagtaggttatgGCTTGACAaaa aatatatattaATTAATAATTCATATATAATtagaattattattgaaagcgattatgc t" /listShort="ahpC, ahpF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3736126..3736145 /Source="Nicolas_upshift_promotors" /id="U3154" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.532467532467532" /psig=1 /xcortree=2087 /SigmaFactorBS="cctttattaagatgaaaaaaagtaggttatgGCTTGACAaaa aatatatattaATTAATAATTCATATATAATtagaattattattgaaagcgattatgc t" /listShort="ahpC, ahpF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3736133 /Source="Nicolas_upshifts" /id="U3154" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.532467532467532" /psig=1 /xcortree=2087 /SigmaFactorBS="cctttattaagatgaaaaaaagtaggttatgGCTTGACAaaa aatatatattaATTAATAATTCATATATAATtagaattattattgaaagcgattatgc t" /listShort="ahpC, ahpF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3736155..3736162 /Source="Nicolas_upshift_promotors" /id="U3156" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.636363636363636" /psig="0.983016983016983" /xcortree=2089 /SigmaFactorBS="aattcatatataattagaattatTATTGAAAgcgattatgct ttcTAATACATTTTTAGGAGGAAtatacattatgtctttaatcggtaaagaagtactt c" /listShort="ahpC, ahpF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3736177..3736196 /Source="Nicolas_upshift_promotors" /id="U3156" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.636363636363636" /psig="0.983016983016983" /xcortree=2089 /SigmaFactorBS="aattcatatataattagaattatTATTGAAAgcgattatgct ttcTAATACATTTTTAGGAGGAAtatacattatgtctttaatcggtaaagaagtactt c" /listShort="ahpC, ahpF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3736180) /Source="Nicolas_upshifts" /id="U3155" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.914085914085914" /psig="0.047952047952048" /xcortree=299 /SigmaFactorBS="ttcgaatggaagtacttctttaccgattaaaGACATaatgta tATTCCTCCTAAAAATgtattagaaagcataatcgctttcaataataattctaattat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3736183..3736197) /Source="Nicolas_upshift_promotors" /id="U3155" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.914085914085914" /psig="0.047952047952048" /xcortree=299 /SigmaFactorBS="ttcgaatggaagtacttctttaccgattaaaGACATaatgta tATTCCTCCTAAAAATgtattagaaagcataatcgctttcaataataattctaattat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3736192 /Source="Nicolas_upshifts" /id="U3156" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.636363636363636" /psig="0.983016983016983" /xcortree=2089 /SigmaFactorBS="aattcatatataattagaattatTATTGAAAgcgattatgct ttcTAATACATTTTTAGGAGGAAtatacattatgtctttaatcggtaaagaagtactt c" /listShort="ahpC, ahpF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3736205..3736209) /Source="Nicolas_upshift_promotors" /id="U3155" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.914085914085914" /psig="0.047952047952048" /xcortree=299 /SigmaFactorBS="ttcgaatggaagtacttctttaccgattaaaGACATaatgta tATTCCTCCTAAAAATgtattagaaagcataatcgctttcaataataattctaattat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3736205..3736768 /gene="ahpC" /locus_tag="BSU_40090" /old_locus_tag="BSU40090" /EC_number="1.11.1.5" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8932315, 14766928, 26322180" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8932315, 14766928, 26322180; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alkyl hydroperoxide reductase (small subunit)" /protein_id="NP_391889.1" /db_xref="EnsemblGenomes-Gn:BSU40090" /db_xref="EnsemblGenomes-Tr:CAB16046" /db_xref="GOA:P80239" /db_xref="InterPro:IPR000866" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR017559" /db_xref="InterPro:IPR019479" /db_xref="InterPro:IPR024706" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG11385" /db_xref="UniProtKB/Swiss-Prot:P80239" /translation="MSLIGKEVLPFEAKAFKNGEFIDVTNEDLKGQWSVFCFYPADFS FVCPTELEDLQEQYAALKELGVEVYSVSTDTHFVHKGWHDSSEKISKITYAMIGDPSQ TISRNFDVLDEETGLADRGTFIIDPDGVIQTVEINAGGIGRDASNLVNKVKAAQYVRQ NPGEVCPAKWEEGGETLTPSLDLVGKI*" /label="ahpC CDS" gene 3736205..3736768 /gene="ahpC" /locus_tag="BSU_40090" /old_locus_tag="BSU40090" /label="ahpC gene" CDS 3736782..3738311 /gene="ahpF" /locus_tag="BSU_40100" /old_locus_tag="BSU40100" /EC_number="1.6.99.3" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8932314, 14766928, 16232966, 23899494" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8932314, 14766928, 16232966, 23899494; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alkyl hydroperoxide reductase (large subunit)" /protein_id="NP_391890.1" /db_xref="EnsemblGenomes-Gn:BSU40100" /db_xref="EnsemblGenomes-Tr:CAB16047" /db_xref="GOA:P42974" /db_xref="InterPro:IPR000103" /db_xref="InterPro:IPR002109" /db_xref="InterPro:IPR008255" /db_xref="InterPro:IPR012081" /db_xref="InterPro:IPR012336" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG11204" /db_xref="UniProtKB/Swiss-Prot:P42974" /translation="MVLDANIKAQLNQYMQLIENDIVLKVSAGEDDTSKDMLALVDEL ASMSSKISVEKAELNRTPSFSVNRVGEDTGVTFAGIPLGHEFTSLVLALLQVSGRPPK VDQKVIDQVKKISGEYHFESYISLTCHNCPDVVQALNMMSVLNPNITHTMIDGAAYKA EVESKNIMAVPTVYLNGESFGSGRMTLEEILAKMGSGTDASEFADKEPFDVLVVGGGP AGASAAIYTARKGIRTGVVAERFGGQVLDTMSIENFISVKATEGPKLAASLEEHVKEY DIDVMNLQRAKRLEKKDLFELELENGAVLKSKTVILSTGARWRNVNVPGEQEFKNKGV AYCPHCDGPLFEGKDVAVIGGGNSGIEAAIDLAGIVNHVTVLEFAPELKADEVLQKRL YSLPNVTVVKNAQTKEITGDQSVNGITYVDRETGEEKHVELQGVFVQIGLVPNTEWLE GTVERNRMGEIIVDKHGATSVPGLFAAGDCTDSAYNQIIISMGSGATAALGAFDYLIR N*" /label="ahpF CDS" gene 3736782..3738311 /gene="ahpF" /locus_tag="BSU_40100" /old_locus_tag="BSU40100" /label="ahpF gene" downshifts complement(3738138) /Source="Nicolas_upshifts" /id="D2073" /incds=1 /nref=1 /ntot=9 /MaxReadThrough="3.25325" /MaxDrop="3.69049" /score="1.76901559" /energy="-18" /TU="NA" /idTUdmin="U3157" /TUdmin=198 /isTUend="FALSE" /label="downshifts" downshifts 3738304 /Source="Nicolas_upshifts" /id="D2074" /incds=0 /nref=248 /ntot=268 /MaxReadThrough="3.92009" /MaxDrop="8.88048" /score="33.1934883" /energy="-19.6" /TU="U3154" /idTUdmin="U3156" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3738337..3738420) /Source="Nicolas_S_feature" /locus_tag="new_4121082_4121165_c" /HighExp="G150, C30, LPhT, G135, S8, LBGstat, T0.30H, G180, Diami, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1541" downshifts complement(3738380) /Source="Nicolas_upshifts" /id="D2075" /incds=0 /nref=1 /ntot=40 /MaxReadThrough="3.37922" /MaxDrop="4.44094" /score="1.76901559" /energy="-18" /TU="U3157" /idTUdmin="U3157" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" CDS complement(3738421..3739860) /gene="bglA" /locus_tag="BSU_40110" /old_locus_tag="BSU40110" /EC_number="3.2.1.86" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8125345, 14652714, 15139916" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8125345, 14652714, 15139916; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aryl-6-phospho-beta-glucosidase" /protein_id="NP_391891.1" /db_xref="EnsemblGenomes-Gn:BSU40110" /db_xref="EnsemblGenomes-Tr:CAB16048" /db_xref="GOA:P42973" /db_xref="InterPro:IPR001360" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR018120" /db_xref="InterPro:IPR033132" /db_xref="SubtiList:BG11203" /db_xref="UniProtKB/Swiss-Prot:P42973" /translation="MGNMPKDFLWGGALAAHQFEGGWNQGGKGPSVVDVMTAGAHGVP RKITDTIEENEFYPNHEAIDFYHRYKEDIALFAEMGLKCLRTSIGWSRIFPKGDEAEP NEAGLQFYDDVFDELLKHGIEPVITLSHFEMPLHLAREYGGFRNRKVVDFFVNFAEAC FTRYKDKVKYWMTFNEINNQMDVNNPLFLWTNSGVVVGENENAKEVMYQTAHHELVAS ALAVAKGKDINPEFQIGAMVSHVPIYPFSSNPEDVMLAEEEMRQRYFFPDVQVRGYYP SYALKEFEREGYNITFEDGDDEILRNGTVDYLGFSYYMSTTVKSDVKNDNTGDIVNGG LPNGVENPYITSSDWGWAIDPTGLRYTLNRFYDRYQIPLFIVENGFGAVDTLEEDGKV HDPERIQYLKSHIEALKKAVTYDGVDLIGYTPWGIIDIVSFTTGEMKKRYGMIYVDRD NEGNGSMKRYKKDSFEWYKNVIQTNGEEL*" /label="bglA CDS" gene complement(3738421..3739860) /gene="bglA" /locus_tag="BSU_40110" /old_locus_tag="BSU40110" /label="bglA gene" CDS complement(3739874..3740104) /gene="ptsJ" /locus_tag="BSU_40120" /old_locus_tag="BSU40120" /EC_number="2.7.1.-" /function="16.3: Control" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12867744, 28731580" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12867744, 28731580; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glucose phosphotransferase system enzyme IIA component" /protein_id="NP_391892.1" /db_xref="EnsemblGenomes-Gn:BSU40120" /db_xref="EnsemblGenomes-Tr:CAB16049" /db_xref="GOA:O32292" /db_xref="InterPro:IPR001127" /db_xref="InterPro:IPR011055" /db_xref="SubtiList:BG14172" /db_xref="UniProtKB/Swiss-Prot:O32292" /translation="MVTPTKHAIGLRSASGVELLAHIGLDTVTFDGTPFSLKVKEGDT VKKGEVLVEFDKAFIEDIEESALHQKIFTVVS*" /label="ptsJ CDS" gene complement(3739874..3740104) /gene="ptsJ" /locus_tag="BSU_40120" /old_locus_tag="BSU40120" /label="ptsJ gene" S_feature complement(3740105..3740316) /Source="Nicolas_S_feature" /locus_tag="new_4122850_4123061_c" /HighExp="G150, LPhT, T0.30H, Diami, G135, LBGstat, G180, Oxctl, Lbexp, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1542" promotor_-10 complement(3740313..3740332) /Source="Nicolas_upshift_promotors" /id="U3157" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.811188811188811" /psig=1 /xcortree=1576 /SigmaFactorBS="tagtgcgtaaatattttgtttcggAATTGATAaattataccg ttacAATTATAATGAAAGCGTAACcaaaacgaaggggtgggtgaaatgtcggggaaag t" /listShort="S1542, yyzE, bglA, S1541" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3740318) /Source="Nicolas_upshifts" /id="U3157" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.811188811188811" /psig=1 /xcortree=1576 /SigmaFactorBS="tagtgcgtaaatattttgtttcggAATTGATAaattataccg ttacAATTATAATGAAAGCGTAACcaaaacgaaggggtgggtgaaatgtcggggaaag t" /listShort="S1542, yyzE, bglA, S1541" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3740347..3740354) /Source="Nicolas_upshift_promotors" /id="U3157" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.811188811188811" /psig=1 /xcortree=1576 /SigmaFactorBS="tagtgcgtaaatattttgtttcggAATTGATAaattataccg ttacAATTATAATGAAAGCGTAACcaaaacgaaggggtgggtgaaatgtcggggaaag t" /listShort="S1542, yyzE, bglA, S1541" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3740380..3740387 /Source="Nicolas_upshift_promotors" /id="U3158" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=1557 /SigmaFactorBS="ttccgaaacaaaatatttacgcactaaCTATCATTgtaagcg gttTATGCTATAATTTTGACAAGtgaaactaaacgaataaatgaggaatgcgtatgtt a" /listShort="yydK, yyzN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3740398..3740417 /Source="Nicolas_upshift_promotors" /id="U3158" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=1557 /SigmaFactorBS="ttccgaaacaaaatatttacgcactaaCTATCATTgtaagcg gttTATGCTATAATTTTGACAAGtgaaactaaacgaataaatgaggaatgcgtatgtt a" /listShort="yydK, yyzN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3740413 /Source="Nicolas_upshifts" /id="U3158" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=1557 /SigmaFactorBS="ttccgaaacaaaatatttacgcactaaCTATCATTgtaagcg gttTATGCTATAATTTTGACAAGtgaaactaaacgaataaatgaggaatgcgtatgtt a" /listShort="yydK, yyzN" /GFF_Attribute="listLong" /label="upshifts" CDS 3740448..3741158 /gene="yydK" /locus_tag="BSU_40130" /old_locus_tag="BSU40130" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (GntR family)" /protein_id="NP_391893.1" /db_xref="EnsemblGenomes-Gn:BSU40130" /db_xref="EnsemblGenomes-Tr:CAB16050" /db_xref="GOA:Q45591" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR011663" /db_xref="InterPro:IPR028978" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:3BWG" /db_xref="SubtiList:BG11484" /db_xref="UniProtKB/Swiss-Prot:Q45591" /translation="MLKYQQIATEIETYIEEHQLQQGDKLPVLETLMAQFEVSKSTIT KSLELLEQKGAIFQVRGSGIFVRKHKRKGYISLLSNQGFKKDLEDFNVTSKVIELDVR KPTPEAAENLNIGMDEDIYYVKRVRYINGQTLCYEESYYTKSIVTYLNNEIVSHSIFH YIREGLGLKIGFSDLFLHVGQLNEEEAEYLGLEAGLPKLYIESIFHLTNGQPFDYSKI SYNYEQSQFVVQANSFLL*" /label="yydK CDS" gene 3740448..3741158 /gene="yydK" /locus_tag="BSU_40130" /old_locus_tag="BSU40130" /label="yydK gene" CDS 3741186..3741344 /gene="yyzN" /locus_tag="BSU_40139" /old_locus_tag="BSU40139" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097799.1" /db_xref="EnsemblGenomes-Gn:BSU40139" /db_xref="EnsemblGenomes-Tr:CAX52714" /db_xref="GOA:C0H3T8" /db_xref="UniProtKB/Swiss-Prot:C0H3T8" /translation="MYKIIIPAILAIFALWILLQISLEMSIVKNPMNYFIVFIIFFLF VKMVKEKQ*" /label="yyzN CDS" gene 3741186..3741344 /gene="yyzN" /locus_tag="BSU_40139" /old_locus_tag="BSU40139" /label="yyzN gene" downshifts 3741421 /Source="Nicolas_upshifts" /id="D2076" /incds=0 /nref=16 /ntot=177 /MaxReadThrough="0.96913" /MaxDrop="4.2349" /score="-9.95345673" /energy="-14.7" /TU="NA" /idTUdmin="U3158" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(3741475..3742197) /gene="liaM" /locus_tag="BSU_40140" /old_locus_tag="BSU40140" /function="16.1: Circulate" /function="16.3: Control" /function="16.4: Excrete" /experiment="publication(s) with functional evidences, PMID:15743949, 15849754, 16850406, 17921301, 28644475" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15743949, 15849754, 16850406, 17921301, 28644475; Product type t : transporter" /codon_start=1 /transl_table=11 /product="permease for export of regulatory peptide LiaD*" /protein_id="NP_391894.1" /db_xref="EnsemblGenomes-Gn:BSU40140" /db_xref="EnsemblGenomes-Tr:CAB16051" /db_xref="GOA:Q45592" /db_xref="SubtiList:BG11483" /db_xref="UniProtKB/Swiss-Prot:Q45592" /translation="MKLEFKKSISNKVIIILGAMFVFLFLLGYFLLVGIDKVSNVTPE MFFFSSYTVATQFGLMLFSFVIAFFINREYSNKNILFYKLIGENIYTFFYKKIAVLFL ECFAFITLGLLIISLMYHDFSHFALLLFLFSAVILQYILIIGTISVLCPNILISIGVS IVYWMTSVILVAISNKTFGFIAPFEAGNTMYPRIERVLQSDNMTLGSNDVLFIILYLV SIIIINAIVLRFSKTRWIKMGL*" /label="liaM CDS" gene complement(3741475..3742197) /gene="liaM" /locus_tag="BSU_40140" /old_locus_tag="BSU40140" /label="liaM gene" downshifts complement(3741487) /Source="Nicolas_upshifts" /id="D2077" /incds=0 /nref=225 /ntot=267 /MaxReadThrough="2.70741" /MaxDrop="6.21099" /score="7.49162587" /energy="-10.5" /TU="NA" /idTUdmin="U3160" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" promotor_-35 3742098..3742101 /Source="Nicolas_upshift_promotors" /id="U3159" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.975024975024975" /psig="0.014985014985015" /xcortree=48 /SigmaFactorBS="tgtaacattactgactttatcgattcCAACaagtaaaaaata accCAGCAaaaataaaaatacaaacattgctcctaaaataatgataactttgttgcta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3742117..3742121 /Source="Nicolas_upshift_promotors" /id="U3159" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.975024975024975" /psig="0.014985014985015" /xcortree=48 /SigmaFactorBS="tgtaacattactgactttatcgattcCAACaagtaaaaaata accCAGCAaaaataaaaatacaaacattgctcctaaaataatgataactttgttgcta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3742132 /Source="Nicolas_upshifts" /id="U3159" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.975024975024975" /psig="0.014985014985015" /xcortree=48 /SigmaFactorBS="tgtaacattactgactttatcgattcCAACaagtaaaaaata accCAGCAaaaataaaaatacaaacattgctcctaaaataatgataactttgttgcta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3742218..3742847) /gene="liaL" /locus_tag="BSU_40150" /old_locus_tag="BSU40150" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15743949, 15849754, 16850406, 17921301, 28644475" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15743949, 15849754, 16850406, 17921301, 28644475; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC transporter for regulatory peptide LiaD* (ATP-binding protein)" /protein_id="NP_391895.1" /db_xref="EnsemblGenomes-Gn:BSU40150" /db_xref="EnsemblGenomes-Tr:CAB16052" /db_xref="GOA:Q45593" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11482" /db_xref="UniProtKB/Swiss-Prot:Q45593" /translation="MNIANYTLKVKGKTLLQDTDLHFSSGKINHVVGKNGVGKSQLAK DFLLNNSKRIGRDIRQNVSLISSSSNIPNDVSKDFLLHFLSKKFDAKMIDKIAYLLNL DNIDGKVLIKNLSDGQKQKLKLLSFLLEDKNIIVLDEITNSLDKKTVIEIHGFLNKYI QENPEKIIINITHDLSDLKAIEGDYYIFNHQEIQQYHSVDKLIEVYINE*" /label="liaL CDS" gene complement(3742218..3742847) /gene="liaL" /locus_tag="BSU_40150" /old_locus_tag="BSU40150" /label="liaL gene" S_feature complement(3742848..3742996) /Source="Nicolas_S_feature" /locus_tag="new_4125593_4125741_c" /HighExp="T-0.40H, LoTm, T-2.40H, T0.0H, M9-tran, SMMPr, T-1.40H, GM 150, T-3.40H, T-4.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1543" CDS complement(3742997..3743755) /gene="liaK" /locus_tag="BSU_40160" /old_locus_tag="BSU40160" /function="16.3: Control" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15743949, 15849754, 16850406, 17921301, 28644475" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15743949, 15849754, 16850406, 17921301, 28644475; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="membrane metalloprotease acting on modified factor LiaD" /protein_id="NP_391896.2" /db_xref="EnsemblGenomes-Gn:BSU40160" /db_xref="EnsemblGenomes-Tr:CAB16053" /db_xref="GOA:Q45594" /db_xref="SubtiList:BG11481" /db_xref="UniProtKB/Swiss-Prot:Q45594" /translation="MKILKYEDEKYEVLVQNNVFIKDKKSGEYYKNSLNSLSDKQLLR FKMYKEKVSPKFFYLFLSFTALMFILNYIHLIKLQNGLSSVFYGWKMWIIIVIYFIMN IVLHELGHIYSLKFFGKNFDKVGFKLNFYVFPAFYVQLNETYMLSRNEKIIVHLFGLF INYLLINTLELINQFTFSSEALTMAFMLFSSTLLWNLIPILNSDGYKILLAFLSLDEY SRFKTNHWLVLTIQIIGIGLAVNSVVHWILYIVN*" /label="liaK CDS" gene complement(3742997..3743755) /gene="liaK" /locus_tag="BSU_40160" /old_locus_tag="BSU40160" /label="liaK gene" promotor_-10 complement(3743445..3743464) /Source="Nicolas_upshift_promotors" /id="U3160" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig=1 /xcortree=2954 /SigmaFactorBS="caaaatggattgtcctcagtattttacggctggaaaaTGTGG ATAattatagttattTATTTTATAATGAATATAGTgcttcatgaactgggacatattt a" /listShort="S1543, yydI, yydJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3743461) /Source="Nicolas_upshifts" /id="U3160" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig=1 /xcortree=2954 /SigmaFactorBS="caaaatggattgtcctcagtattttacggctggaaaaTGTGG ATAattatagttattTATTTTATAATGAATATAGTgcttcatgaactgggacatattt a" /listShort="S1543, yydI, yydJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3743477..3743484) /Source="Nicolas_upshift_promotors" /id="U3160" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig=1 /xcortree=2954 /SigmaFactorBS="caaaatggattgtcctcagtattttacggctggaaaaTGTGG ATAattatagttattTATTTTATAATGAATATAGTgcttcatgaactgggacatattt a" /listShort="S1543, yydI, yydJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3743736..3744695) /gene="liaE" /locus_tag="BSU_40170" /old_locus_tag="BSU40170" /EC_number="5.1.1.-" /experiment="publication(s) with functional evidences, PMID:17921301, 18307109, 28644475" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17921301, 18307109, 28644475; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="AdoMet radical amino acid epimerase modifying factor LiaD" /protein_id="NP_391897.1" /db_xref="EnsemblGenomes-Gn:BSU40170" /db_xref="EnsemblGenomes-Tr:CAB16054" /db_xref="GOA:Q45595" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR023404" /db_xref="InterPro:IPR023904" /db_xref="InterPro:IPR034395" /db_xref="SubtiList:BG11480" /db_xref="UniProtKB/Swiss-Prot:Q45595" /translation="MYNKTVSINLDSRCNASCDHCCFSSSPTSTTRMEKEYIRELVTE FAKNKTIQVISFTGGEVFLDYKFLKELMEIIKPYEKQITLISNGFWGLSKKKVQEYFH DMNSLNVIALTISYDEYHAPFVKSSSIKNILEHSRKYPDIDISLNMAVTKDKMSNHIL EELGDSILGVKITKFPMISVGAAKTRIKQENIHKFYSLEDEDSLHCPGYDIVYHHDGE IYPCCSPAIFETKITLREEYNQSFERTVEKLNSNLLLFILRKEGFKWFLNILKENNKI EEFDIPYEFSSICGVCGSLFNSAEKINYFYPYMEKYYNENFKV*" /label="liaE CDS" gene complement(3743736..3744695) /gene="liaE" /locus_tag="BSU_40170" /old_locus_tag="BSU40170" /label="liaE gene" downshifts 3744684 /Source="Nicolas_upshifts" /id="D2078" /incds=0 /nref=1 /ntot=14 /MaxReadThrough="3.40583" /MaxDrop="2.5017" /score="-9.12840375" /energy="-9.4" /TU="NA" /idTUdmin="U3161" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" misc_feature 3744731..3744734 /Source="Nicolas_upshift_promotors" /id="U3161" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.380619380619381" /psig="0.304695304695305" /xcortree=119 /SigmaFactorBS="actgttttattatacatgaaatatcccccaacaaatggtaaa ggagagttagACTCtcctttgtacccctctaattaatgaccacttccaagaatccagc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3744739 /Source="Nicolas_upshifts" /id="U3161" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.380619380619381" /psig="0.304695304695305" /xcortree=119 /SigmaFactorBS="actgttttattatacatgaaatatcccccaacaaatggtaaa ggagagttagACTCtcctttgtacccctctaattaatgaccacttccaagaatccagc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3744753..3744902) /gene="liaD" /locus_tag="BSU_40180" /old_locus_tag="BSU40180" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15101989, 17921301, 28644475" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15101989, 17921301, 28644475; Product type r: regulator" /codon_start=1 /transl_table=11 /product="precursor of exported modified peptide (epipeptide) controlling LiaRS activity" /protein_id="NP_391898.1" /db_xref="EnsemblGenomes-Gn:BSU40180" /db_xref="EnsemblGenomes-Tr:CAB16055" /db_xref="InterPro:IPR023898" /db_xref="SubtiList:BG11479" /db_xref="UniProtKB/Swiss-Prot:Q45596" /translation="MKKEITNNETVKNLEFKGLLDESQKLAKVNDLWYFVKSKENRWI LGSGH*" /label="liaD CDS" gene complement(3744753..3744902) /gene="liaD" /locus_tag="BSU_40180" /old_locus_tag="BSU40180" /label="liaD gene" downshifts complement(3744760) /Source="Nicolas_upshifts" /id="D2079" /incds=0 /nref=99 /ntot=172 /MaxReadThrough="7.62324" /MaxDrop="6.01674" /score="7.49162587" /energy="-10.5" /TU="U3163" /idTUdmin="U3167" /TUdmin=2794 /isTUend="FALSE" /label="downshifts" misc_feature 3744811..3744828 /Source="Nicolas_upshift_promotors" /id="U3162" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.342657342657343" /psig="0.342657342657343" /xcortree=651 /SigmaFactorBS="atgaccacttccaagaatccagcgattttcttttgattttac aaaataccaaagaTCATTCACTTTTGCTAACttttgtgattcatctaatagaccctta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3744816 /Source="Nicolas_upshifts" /id="U3162" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.342657342657343" /psig="0.342657342657343" /xcortree=651 /SigmaFactorBS="atgaccacttccaagaatccagcgattttcttttgattttac aaaataccaaagaTCATTCACTTTTGCTAACttttgtgattcatctaatagaccctta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 3744897 /Source="Nicolas_upshifts" /id="D2080" /incds=0 /nref=99 /ntot=170 /MaxReadThrough="2.55247" /MaxDrop="5.95806" /score="-9.12840375" /energy="-9.4" /TU="NA" /idTUdmin="U3161" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3744923..3744942) /Source="Nicolas_upshift_promotors" /id="U3163" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2870 /SigmaFactorBS="ccaagaatagtgacatttttcagattttttaggtacaataTA TTGACAtgtattgaatgataTAGAATAATTGGTTTATATTagaaaaggaggagggata a" /listShort="yydF, yydG, yydH, S1543, yydI, yydJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3744944) /Source="Nicolas_upshifts" /id="U3163" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2870 /SigmaFactorBS="ccaagaatagtgacatttttcagattttttaggtacaataTA TTGACAtgtattgaatgataTAGAATAATTGGTTTATATTagaaaaggaggagggata a" /listShort="yydF, yydG, yydH, S1543, yydI, yydJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3744957..3744964) /Source="Nicolas_upshift_promotors" /id="U3163" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2870 /SigmaFactorBS="ccaagaatagtgacatttttcagattttttaggtacaataTA TTGACAtgtattgaatgataTAGAATAATTGGTTTATATTagaaaaggaggagggata a" /listShort="yydF, yydG, yydH, S1543, yydI, yydJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3745237..3745244 /Source="Nicolas_upshift_promotors" /id="U3164" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=1990 /SigmaFactorBS="tgcttaccccatttggcacctctttctctcgtttTAATTGTC tctaaaagcagttaTGCGGTACTATCATATAAAGgtccaatgtttaaaaataatgtca t" /listShort="fbp, S1544" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3745259..3745278 /Source="Nicolas_upshift_promotors" /id="U3164" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=1990 /SigmaFactorBS="tgcttaccccatttggcacctctttctctcgtttTAATTGTC tctaaaagcagttaTGCGGTACTATCATATAAAGgtccaatgtttaaaaataatgtca t" /listShort="fbp, S1544" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3745263 /Source="Nicolas_upshifts" /id="U3164" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=1990 /SigmaFactorBS="tgcttaccccatttggcacctctttctctcgtttTAATTGTC tctaaaagcagttaTGCGGTACTATCATATAAAGgtccaatgtttaaaaataatgtca t" /listShort="fbp, S1544" /GFF_Attribute="listLong" /label="upshifts" CDS 3745374..3747299 /gene="fbp" /locus_tag="BSU_40190" /old_locus_tag="BSU40190" /EC_number="3.1.3.11" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:221467, 9696785, 19270101" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 221467, 9696785, 19270101; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fructose-1,6-bisphosphatase" /protein_id="NP_391899.2" /db_xref="EnsemblGenomes-Gn:BSU40190" /db_xref="EnsemblGenomes-Tr:CAB16056" /db_xref="GOA:Q45597" /db_xref="InterPro:IPR009164" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG11478" /db_xref="UniProtKB/Swiss-Prot:Q45597" /translation="MESKYLDLLAQKYDCEEKVVTEIINLKAILNLPKGTEHFVSDLH GEYQAFQHVLRNGSGRVKEKIRDIFSGVIYDREIDELAALVYYPEDKLKLIKHDFDAK EALNEWYKETIHRMIKLVSYCSSKYTRSKLRKALPAQFAYITEELLYKTEQAGNKEQY YSEIIDQIIELGQADKLITGLAYSVQRLVVDHLHVVGDIYDRGPQPDRIMEELINYHS VDIQWGNHDVLWIGAYSGSKVCLANIIRICARYDNLDIIEDVYGINLRPLLNLAEKYY DDNPAFRPKADENRPEDEIKQITKIHQAIAMIQFKLESPIIKRRPNFNMEERLLLEKI DYDKNEITLNGKTYQLENTCFATINPEQPDQLLEEEAEVIDKLLFSVQHSEKLGRHMN FMMKKGSLYLKYNGNLLIHGCIPVDENGNMETMMIEDKPYAGRELLDVFERFLREAFA HPEETDDLATDMAWYLWTGEYSSLFGKRAMTTFERYFIKEKETHKEKKNPYYYLREDE ATCRNILAEFGLNPDHGHIINGHTPVKEIEGEDPIKANGKMIVIDGGFSKAYQSTTGI AGYTLLYNSYGMQLVAHKHFNSKAEVLSTGTDVLTVKRLVDKELERKKVKETNVGEEL LQEVAILESLREYRYMK*" /label="fbp CDS" gene 3745374..3747299 /gene="fbp" /locus_tag="BSU_40190" /old_locus_tag="BSU40190" /label="fbp gene" S_feature 3747300..3748664 /Source="Nicolas_S_feature" /locus_tag="new_4130045_4131409" /HighExp="Lbstat, dia5, C30, Gly, Etha, dia15, C90, Fru, G135, Mal" /AntisenseName="yydD" /AntisenseCor="0.44422072328838003" /AntisenseRegPval="-13.7" /CDS_PredictionProba="0.22050400000000001" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1544" S_feature complement(3747512..3747832) /Source="Nicolas_S_feature" /locus_tag="new_4130257_4130577_c" /HighExp="Cold, C30, M/G, S8, Fru, nit, Glu, BMM, Heat, MG 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S1545" CDS complement(3747833..3749593) /gene="yydD" /locus_tag="BSU_40200" /old_locus_tag="BSU40200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative DNA wielding protein" /protein_id="NP_391900.1" /db_xref="EnsemblGenomes-Gn:BSU40200" /db_xref="EnsemblGenomes-Tr:CAB16057" /db_xref="InterPro:IPR018760" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11477" /db_xref="UniProtKB/Swiss-Prot:Q45598" /translation="MIVMIIKNLFVCNSQEILKEYKFNAVGVNIILGEKREDHEETNG VGKSTMIECISFLLGKTISNFYTTNEILLNKNVFIVLNVEIDGNQVFLARSFNSPKHG YTLHDTSLTFNLEEWKKVSISVYKKFIEKEILKGEKEDITFAALREYIIRDEKTGFND IVLPNRGGLKQYKLLNYLFTLPTHTEKNIKVFRDKIEKLNSEIKLIESMNINIGDLKV KEDELINEIEDYNRVIYQTKTANKYNNDTNRYSEIKSELNKIQNEIFENEHICKQYQR NIDDLNKKVTKIKELENIEKFYEDIVGFFPEEVKQNYNKVQEFYNFMVESRGSYFKDK IVKIQADLKKLNIKKQGLTEQLESSARILKSNNFIEDISIVMEEQRRKEIELAEVRLR ISDYDKKNHIFDKINELQHEILRVNSMYYDEFQSYSAIVSELKKLFNNLMDVTYNQHG FLDFEYDNRISNAKQSTTGRIKISCSIPDERSHGRLHMKINIFDLTWFLYRCINKCSL NILIHDGSYSNPDPHVKGTLLKHINSSLLENRIGQYFVTINKNELLLDDLQELESKGM IVAKLDRNNEDKNRFFGFRF*" /label="yydD CDS" gene complement(3747833..3749593) /gene="yydD" /locus_tag="BSU_40200" /old_locus_tag="BSU40200" /label="yydD gene" downshifts complement(3747876) /Source="Nicolas_upshifts" /id="D2081" /incds=0 /nref=11 /ntot=199 /MaxReadThrough="4.99391" /MaxDrop="4.47843" /score="7.49162587" /energy="-10.5" /TU="U3167" /idTUdmin="U3167" /TUdmin="-322" /isTUend="FALSE" /label="downshifts" misc_feature 3748661..3748662 /Source="Nicolas_upshift_promotors" /id="U3165" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.67032967032967" /psig="0.255744255744256" /xcortree=83 /SigmaFactorBS="aactccctctactttctaccatgaaattatagaactcttgga ctttattataattCTgttttacttcctctggaaaaaaacctacaatatcttcatagaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3748666 /Source="Nicolas_upshifts" /id="U3165" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.67032967032967" /psig="0.255744255744256" /xcortree=83 /SigmaFactorBS="aactccctctactttctaccatgaaattatagaactcttgga ctttattataattCTgttttacttcctctggaaaaaaacctacaatatcttcatagaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3749593..3749991) /gene="yydC" /locus_tag="BSU_40210" /old_locus_tag="BSU40210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391901.1" /db_xref="EnsemblGenomes-Gn:BSU40210" /db_xref="EnsemblGenomes-Tr:CAB16058" /db_xref="SubtiList:BG11476" /db_xref="UniProtKB/Swiss-Prot:Q45599" /translation="MIDLKIETAENILKYSYVLLENEFKNIQIGNDLIPLVNNSPLKK EKAERPEMNHFLLTKYNAVEENILYSSKILYELLEKEKHIDQLFLDYAKSQGIIINLN IERILYLSLTFLYSLGKVSFNQNMISRTES*" /label="yydC CDS" gene complement(3749593..3749991) /gene="yydC" /locus_tag="BSU_40210" /old_locus_tag="BSU40210" /label="yydC gene" CDS complement(3749984..3751429) /gene="yydB" /locus_tag="BSU_40220" /old_locus_tag="BSU40220" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphohydrolase" /protein_id="NP_391902.1" /db_xref="EnsemblGenomes-Gn:BSU40220" /db_xref="EnsemblGenomes-Tr:CAB16059" /db_xref="GOA:Q45600" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG11475" /db_xref="UniProtKB/Swiss-Prot:Q45600" /translation="MKVRFLQISDLHFQFQNYDTIVMRDKLLDFIEVLRRESDFDFLL LTGDIAHKGDVYNEDVKEYLNGIIKSMGLSKNNVHLVPGNHDISRDMTRTLLIDSIMK SPNPSEMLDKLDQKATNILVEGQRKFFDFYEDFMGVKYPEEDLHFLYQSEKYNVLSIN TCLLSDKKGEEGTLLTAQMKLYKAIRKMNKEKNKGKVLNIAIGHHTLGCIESSERESI KAHFDDYFIDLYLAGHVHDSSFNITANTNENPFLELVSGAIIKDEYATPEFISVDVNL DNGETEVTYYIWNTEYKYWSKNNQGGRRLQEGKLNYKINRLESLIEKEIEDNDDKIDE DEFKSFIIDFHEYRESYKTFTSNFDNQIGLDKKFYDMKSGETFKRKFDSYSEYFGVIN HIMDSTSYVSADKKELIAETIVDKYLEFHNQYNNGDEIFVKIVNEIYLECHSVLPYSK ALTKKYIKILTCWCIYECEIFNDNKRSVKND*" /label="yydB CDS" gene complement(3749984..3751429) /gene="yydB" /locus_tag="BSU_40220" /old_locus_tag="BSU40220" /label="yydB gene" promotor_-35 3750679..3750686 /Source="Nicolas_upshift_promotors" /id="U3166" /multdbtbs="-" /comp="M11" /sig="Sig-" /pcomp="0.353646353646354" /psig="0.430569430569431" /xcortree=94 /SigmaFactorBS="tttataatggctccacttactaattctaagaATGGATTTtca tttgtattTGCAGTAATATTAAATGAAGaatcatgtacatgtcctgccaaatatagat c" /listShort="S1546" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3750698..3750717 /Source="Nicolas_upshift_promotors" /id="U3166" /multdbtbs="-" /comp="M11" /sig="Sig-" /pcomp="0.353646353646354" /psig="0.430569430569431" /xcortree=94 /SigmaFactorBS="tttataatggctccacttactaattctaagaATGGATTTtca tttgtattTGCAGTAATATTAAATGAAGaatcatgtacatgtcctgccaaatatagat c" /listShort="S1546" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3750708..3751757 /Source="Nicolas_S_feature" /locus_tag="new_4133453_4134502" /HighExp="C30, Salt, Gly, S8, Etha, LPhT, T0.30H, Heat, C90, M9-stat" /AntisenseName="yydB" /AntisenseCor="0.36202116146901597" /AntisenseRegPval="-9" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.431" /TUlongSig="NA" /TUlongPSig="NA" /label="S1546" upshifts 3750708 /Source="Nicolas_upshifts" /id="U3166" /multdbtbs="-" /comp="M11" /sig="Sig-" /pcomp="0.353646353646354" /psig="0.430569430569431" /xcortree=94 /SigmaFactorBS="tttataatggctccacttactaattctaagaATGGATTTtca tttgtattTGCAGTAATATTAAATGAAGaatcatgtacatgtcctgccaaatatagat c" /listShort="S1546" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3751430..3751690) /Source="Nicolas_S_feature" /locus_tag="new_4134175_4134435_c" /HighExp="Cold, M0t90, Lbtran, M40t90, Lbstat, T0.30H, MG 150, M40t45, Gly, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S1547" CDS complement(3751691..3752170) /gene="rlmH" /locus_tag="BSU_40230" /old_locus_tag="BSU40230" /EC_number="2.1.1.177" /function="16.6: Maintain" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 18755835, 20817755, 22411911, 22720735, 28428565; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="23S rRNA (pseudouridine1915-N3)-methyltransferase" /protein_id="NP_391903.1" /db_xref="EnsemblGenomes-Gn:BSU40230" /db_xref="EnsemblGenomes-Tr:CAB16060" /db_xref="GOA:Q45601" /db_xref="InterPro:IPR003742" /db_xref="InterPro:IPR029026" /db_xref="InterPro:IPR029028" /db_xref="PDB:1TO0" /db_xref="SubtiList:BG11474" /db_xref="UniProtKB/Swiss-Prot:Q45601" /translation="MNINIVTIGKLKEKYLKQGIEEYTKRLSAYAKIDIIELPDEKAP ENLSDQDMKIIKDKEGDRILSKISPDAHVIALAIEGKMKTSEELADTIDKLATYGKSK VTFVIGGSLGLSDTVMKRADEKLSFSKMTFPHQLMRLILVEQIYRAFRINRGEPYHK* " /label="rlmH CDS" gene complement(3751691..3752170) /gene="rlmH" /locus_tag="BSU_40230" /old_locus_tag="BSU40230" /label="rlmH gene" S_feature complement(3752171..3752250) /Source="Nicolas_S_feature" /locus_tag="new_4134916_4134995_c" /HighExp="dia5, LBGtran, T0.30H, Diami, Cold, M0t90, dia0, M0t45, M40t45, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S1548" CDS complement(3752251..3752421) /gene="yyzF" /locus_tag="BSU_40239" /old_locus_tag="BSU40239" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097800.1" /db_xref="EnsemblGenomes-Gn:BSU40239" /db_xref="EnsemblGenomes-Tr:CAX52715" /db_xref="InterPro:IPR025626" /db_xref="UniProtKB/Swiss-Prot:C0H3T9" /translation="MKQAYYSCEEHIETVLDMYIDDHELPPEIRKIEHTNSLSTACEL CGDPAVYIVGNE*" /label="yyzF CDS" gene complement(3752251..3752421) /gene="yyzF" /locus_tag="BSU_40239" /old_locus_tag="BSU40239" /label="yyzF gene" promotor_-10 complement(3752462..3752481) /Source="Nicolas_upshift_promotors" /id="U3167" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.343656343656344" /psig="0.988011988011988" /xcortree=2306 /SigmaFactorBS="ttgtttgtcgaattgtggataaaactcagcccgaagcaCTAC TAacatgtgaataaaTAGGTTATATTGAGAAGAGAacatttgtaaaaatggaagaaaa c" /listShort="yyzF, S1548, yydA, S1547, yydB, yydC, yydD, S1545" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3752478) /Source="Nicolas_upshifts" /id="U3167" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.343656343656344" /psig="0.988011988011988" /xcortree=2306 /SigmaFactorBS="ttgtttgtcgaattgtggataaaactcagcccgaagcaCTAC TAacatgtgaataaaTAGGTTATATTGAGAAGAGAacatttgtaaaaatggaagaaaa c" /listShort="yyzF, S1548, yydA, S1547, yydB, yydC, yydD, S1545" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3752495..3752500) /Source="Nicolas_upshift_promotors" /id="U3167" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.343656343656344" /psig="0.988011988011988" /xcortree=2306 /SigmaFactorBS="ttgtttgtcgaattgtggataaaactcagcccgaagcaCTAC TAacatgtgaataaaTAGGTTATATTGAGAAGAGAacatttgtaaaaatggaagaaaa c" /listShort="yyzF, S1548, yydA, S1547, yydB, yydC, yydD, S1545" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3752544..3752551 /Source="Nicolas_upshift_promotors" /id="U3168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.549450549450549" /psig="0.994005994005994" /xcortree=415 /SigmaFactorBS="ccacaattcgacaaacaagctgtTGATGACTctatttcgctc gTGTGTTAGTTTGGATGTAACcgatgtgtggggaggtctgcatttgcgctttagatgg g" /listShort="yycS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3752564..3752583 /Source="Nicolas_upshift_promotors" /id="U3168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.549450549450549" /psig="0.994005994005994" /xcortree=415 /SigmaFactorBS="ccacaattcgacaaacaagctgtTGATGACTctatttcgctc gTGTGTTAGTTTGGATGTAACcgatgtgtggggaggtctgcatttgcgctttagatgg g" /listShort="yycS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3752581 /Source="Nicolas_upshifts" /id="U3168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.549450549450549" /psig="0.994005994005994" /xcortree=415 /SigmaFactorBS="ccacaattcgacaaacaagctgtTGATGACTctatttcgctc gTGTGTTAGTTTGGATGTAACcgatgtgtggggaggtctgcatttgcgctttagatgg g" /listShort="yycS" /GFF_Attribute="listLong" /label="upshifts" CDS 3752606..3753019 /gene="yycS" /locus_tag="BSU_40240" /old_locus_tag="BSU40240" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 21911367; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_391904.1" /db_xref="EnsemblGenomes-Gn:BSU40240" /db_xref="EnsemblGenomes-Tr:CAB16061" /db_xref="SubtiList:BG11472" /db_xref="UniProtKB/Swiss-Prot:Q45603" /translation="MRFRWVWLFVIMLLLAECQPSYWVLEKDRIGEGSPDLEIYANYL QMHDDVKGYQVFTISEGKKMVVVSLGSSEKDKKLEVSDVKFSSKETIVTVERKPAPTA NEKNPFILIGLDKIEGDLIVQDETGDRFEETDYQQ*" /label="yycS CDS" gene 3752606..3753019 /gene="yycS" /locus_tag="BSU_40240" /old_locus_tag="BSU40240" /label="yycS gene" downshifts 3752999 /Source="Nicolas_upshifts" /id="D2082" /incds=0 /nref=17 /ntot=131 /MaxReadThrough="1.50241" /MaxDrop="5.73792" /score="16.0382598" /energy="-10.8" /TU="NA" /idTUdmin="U3168" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3753053..3754279) /gene="yycR" /locus_tag="BSU_40250" /old_locus_tag="BSU40250" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 18820069; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dehydrogenase" /protein_id="NP_391905.1" /db_xref="EnsemblGenomes-Gn:BSU40250" /db_xref="EnsemblGenomes-Tr:CAB16062" /db_xref="GOA:Q45604" /db_xref="InterPro:IPR002328" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR014184" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11471" /db_xref="UniProtKB/Swiss-Prot:Q45604" /translation="MGGMALTGNKAVVYKGKGTVAVEDIGYPELILRDGPGVPKANVN RKCEHGVILKVITTNICGSDQHMVRGRTTAPEGLVLGHEITGEVIETGRDVEFIKKGD IVSVPFNIACGRCVMCKTQKTHVCLNVNPDRPGSAYGYVDMGGWVGGQSEYVMVPYAD FQLLVFPDKEQALEKILDLTMLSDIFPTGFHGAYTAGVQTGSTVYIAGAGPVGLAAAH SAQLLGASTVIVGDLNEDRLAQARSFGCETVNVQKHDRLGEQIEQILGEPTVDAAVDC VGFEASGHGNQGEAPAAVLNSIMDVTQVGGSLGIPGLYVTEDPGAKDADAKTGSLKIR FGLGWAKAHTFVTGQTPAMTYNRNLMKAILSGRAQIAKAVNATVISLDDAPKGYSDFD KGAAKKFVIDPHGTLK*" /label="yycR CDS" gene complement(3753053..3754279) /gene="yycR" /locus_tag="BSU_40250" /old_locus_tag="BSU40250" /label="yycR gene" downshifts complement(3753068) /Source="Nicolas_upshifts" /id="D2083" /incds=0 /nref=9 /ntot=123 /MaxReadThrough="0.14321" /MaxDrop="4.77892" /score="8.82768619" /energy="-6.2" /TU="NA" /idTUdmin="U3169" /TUdmin=7 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3754302..3754320) /Source="Nicolas_upshift_promotors" /id="U3169" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=518 /SigmaFactorBS="taagaatacagaaaaaacagtcgtgaaAAAGGGAAAgagtca tgccgAACCGAAGTCATGTTCAAGgacggagagtccaaacacatgaatgggaggaatg g" /listShort="yycR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3754307) /Source="Nicolas_upshifts" /id="U3169" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=518 /SigmaFactorBS="taagaatacagaaaaaacagtcgtgaaAAAGGGAAAgagtca tgccgAACCGAAGTCATGTTCAAGgacggagagtccaaacacatgaatgggaggaatg g" /listShort="yycR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3754332..3754340) /Source="Nicolas_upshift_promotors" /id="U3169" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=518 /SigmaFactorBS="taagaatacagaaaaaacagtcgtgaaAAAGGGAAAgagtca tgccgAACCGAAGTCATGTTCAAGgacggagagtccaaacacatgaatgggaggaatg g" /listShort="yycR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3754342..3754512) /gene="yyzG" /locus_tag="BSU_40259" /old_locus_tag="BSU40259" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097801.1" /db_xref="EnsemblGenomes-Gn:BSU40259" /db_xref="EnsemblGenomes-Tr:CAX52716" /db_xref="GOA:C0H3U0" /db_xref="UniProtKB/Swiss-Prot:C0H3U0" /translation="MQTNRVILLAVMICLVSAITVFLLNGCKVDFLDIGGTIIGCFLG IFVVVRIQKKQS*" /label="yyzG CDS" gene complement(3754342..3754512) /gene="yyzG" /locus_tag="BSU_40259" /old_locus_tag="BSU40259" /label="yyzG gene" promotor_-10 complement(3754531..3754549) /Source="Nicolas_upshift_promotors" /id="U3170" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.681318681318681" /psig="0.681318681318681" /xcortree=259 /SigmaFactorBS="ttatgaagagactggtgtgaagtctctttttttgttgaacCG AAGTTtgcagaggattttGGGTATGGTTTAGAAACGAatccaaaggaggaattacatg c" /listShort="yyzG, yycR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3754549) /Source="Nicolas_upshifts" /id="U3170" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.681318681318681" /psig="0.681318681318681" /xcortree=259 /SigmaFactorBS="ttatgaagagactggtgtgaagtctctttttttgttgaacCG AAGTTtgcagaggattttGGGTATGGTTTAGAAACGAatccaaaggaggaattacatg c" /listShort="yyzG, yycR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3754563..3754569) /Source="Nicolas_upshift_promotors" /id="U3170" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.681318681318681" /psig="0.681318681318681" /xcortree=259 /SigmaFactorBS="ttatgaagagactggtgtgaagtctctttttttgttgaacCG AAGTTtgcagaggattttGGGTATGGTTTAGAAACGAatccaaaggaggaattacatg c" /listShort="yyzG, yycR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3754617..3754865) /gene="yycQ" /locus_tag="BSU_40260" /old_locus_tag="BSU40260" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="conserved membrane protein" /protein_id="NP_391906.1" /db_xref="EnsemblGenomes-Gn:BSU40260" /db_xref="EnsemblGenomes-Tr:CAB16063" /db_xref="GOA:Q45605" /db_xref="InterPro:IPR020258" /db_xref="SubtiList:BG11470" /db_xref="UniProtKB/Swiss-Prot:Q45605" /translation="MGAIAVLFIVFGFPIVAGVFGIAGHFLFKRFWVAPLIVLITSLI LLVTLASGNSSFIFWVVMYTAIALVTSVATLFLRKFFE*" /label="yycQ CDS" gene complement(3754617..3754865) /gene="yycQ" /locus_tag="BSU_40260" /old_locus_tag="BSU40260" /label="yycQ gene" CDS complement(3754881..3756044) /gene="yycP" /locus_tag="BSU_40270" /old_locus_tag="BSU40270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11557812, 16291680" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391907.2" /db_xref="EnsemblGenomes-Gn:BSU40270" /db_xref="EnsemblGenomes-Tr:CAB16064" /db_xref="InterPro:IPR011047" /db_xref="SubtiList:BG11469" /db_xref="UniProtKB/Swiss-Prot:Q45606" /translation="MKKWMITIAMLILAGIALFVFISPLKSHKTVSQQDLRNPDFLDD KEVLLYFSSSADQDAFGGGKSYALFISHDGTLSSFQMKGLELGSAKVHGDSVMLEDKN TIYTIKNGLRSHKRTYQHTGDSAGFLQNTDGFYTLYNSGYDKKGDGYRSELYRQMDGE WKKDVIPYYIRASGFHDGAIYALVPTDDGKGYQLLQIQADQKKLTYLSITEWQYREGA SVESQLAVDDQAVYVMVRGQKAHDLYQMVKINKKSGEVELHDIAEYKNDEQTIYSSMP FSFKNSFFPYDGNLYFIDGFGKVHKIDAKTGKTSIVFTLSPDKMKAEFKEITQKGSSL YFFTYTYHKPAYIEQYSLKTGKKMKEKEIGKVKDVVTPKSHLKLYDVEVMKRF*" /label="yycP CDS" gene complement(3754881..3756044) /gene="yycP" /locus_tag="BSU_40270" /old_locus_tag="BSU40270" /label="yycP gene" promotor_-10 complement(3754915..3754933) /Source="Nicolas_upshift_promotors" /id="U3171" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=531 /SigmaFactorBS="cggaaagaaaatgaaagaaaaagagattggGAAGGTAAAgga tgtcgtgaCGCCGAAGAGTCATTTGAAgctgtatgatgttgaggtgatgaagaggttt t" /listShort="yycQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3754923) /Source="Nicolas_upshifts" /id="U3171" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=531 /SigmaFactorBS="cggaaagaaaatgaaagaaaaagagattggGAAGGTAAAgga tgtcgtgaCGCCGAAGAGTCATTTGAAgctgtatgatgttgaggtgatgaagaggttt t" /listShort="yycQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3754945..3754953) /Source="Nicolas_upshift_promotors" /id="U3171" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=531 /SigmaFactorBS="cggaaagaaaatgaaagaaaaagagattggGAAGGTAAAgga tgtcgtgaCGCCGAAGAGTCATTTGAAgctgtatgatgttgaggtgatgaagaggttt t" /listShort="yycQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3756055..3756792) /gene="yycO" /locus_tag="BSU_40280" /old_locus_tag="BSU40280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16291680" /codon_start=1 /transl_table=11 /product="conserved exported protein" /protein_id="NP_391908.1" /db_xref="EnsemblGenomes-Gn:BSU40280" /db_xref="EnsemblGenomes-Tr:CAB16065" /db_xref="SubtiList:BG11468" /db_xref="UniProtKB/Swiss-Prot:Q45607" /translation="MKLKKRVSMFLVALTMCGGLFVTPAKAVKTTNYAEEIAALQPGT TPEEIMKSASQIAKQQHVKQDVILKQFYKEITADKAEGDRLAKESGMSIMGGSSGTKK LPTSAKGNIYYTNSYTAYYNHGHVGMYSAADKIVESVPSDGVRQIAYNARDVEDNSIV QTVSVSSSQKTAAADWAVSKVGDPYSFNFVNNRNTGHDGAKNCSKLLWSAFLLKAGID IDSNGGLGVYPRDITSSSYTTTIMTIY*" /label="yycO CDS" gene complement(3756055..3756792) /gene="yycO" /locus_tag="BSU_40280" /old_locus_tag="BSU40280" /label="yycO gene" promotor_-10 complement(3756834..3756852) /Source="Nicolas_upshift_promotors" /id="U3172" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.511488511488511" /psig="0.511488511488511" /xcortree=1227 /SigmaFactorBS="acgatttctaaaaattctgtaaataaCCTAGTTACtttcctt attttcCTAATATAATGTGGGTGAGgaaattacctttcctacactcacaagaaaagag g" /listShort="yycO, yycP, yycQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3756840) /Source="Nicolas_upshifts" /id="U3172" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.511488511488511" /psig="0.511488511488511" /xcortree=1227 /SigmaFactorBS="acgatttctaaaaattctgtaaataaCCTAGTTACtttcctt attttcCTAATATAATGTGGGTGAGgaaattacctttcctacactcacaagaaaagag g" /listShort="yycO, yycP, yycQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3756866..3756874) /Source="Nicolas_upshift_promotors" /id="U3172" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.511488511488511" /psig="0.511488511488511" /xcortree=1227 /SigmaFactorBS="acgatttctaaaaattctgtaaataaCCTAGTTACtttcctt attttcCTAATATAATGTGGGTGAGgaaattacctttcctacactcacaagaaaagag g" /listShort="yycO, yycP, yycQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3756934..3757404) /gene="yycN" /locus_tag="BSU_40290" /old_locus_tag="BSU40290" /EC_number="2.3.1.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14635137, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_391909.1" /db_xref="EnsemblGenomes-Gn:BSU40290" /db_xref="EnsemblGenomes-Tr:CAB16066" /db_xref="GOA:O32293" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="PDB:1ON0" /db_xref="PDB:1UFH" /db_xref="SubtiList:BG11467" /db_xref="UniProtKB/Swiss-Prot:O32293" /translation="MTIMLTPMQTEEFRSYLTYTTKHYAEEKVKAGTWLPEDAQLLSK QVFTDLLPRGLETPHHHLWSLKLNEKDIVGWLWIHAEPEHPQQEAFIYDFGLYEPYRG KGYAKQALAALDQAARSMGIRKLSLHVFAHNQTARKLYEQTGFQETDVVMSKKL*" /label="yycN CDS" gene complement(3756934..3757404) /gene="yycN" /locus_tag="BSU_40290" /old_locus_tag="BSU40290" /label="yycN gene" downshifts complement(3756947) /Source="Nicolas_upshifts" /id="D2084" /incds=0 /nref=1 /ntot=78 /MaxReadThrough="3.78599" /MaxDrop="2.94893" /score="8.04802973" /energy="-7.6" /TU="U3175" /idTUdmin="U3174" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3757405..3757475) /Source="Nicolas_S_feature" /locus_tag="new_4140150_4140220_c" /HighExp="S4, S5, S6, LoTm, S3, S7, S8, B36, BT, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="0.997, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1549" promotor_-35 3757436..3757442 /Source="Nicolas_upshift_promotors" /id="U3173" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.551448551448551" /psig="0.995004995004995" /xcortree=3163 /SigmaFactorBS="attgtcatatcatctctccttcatatattgactagaggaTTT TACAtaaaatagaaagaGGTGTTACTATCAGAATAAGcaactgagattgataagtcac t" /listShort="rapG, phrG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3757456..3757475 /Source="Nicolas_upshift_promotors" /id="U3173" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.551448551448551" /psig="0.995004995004995" /xcortree=3163 /SigmaFactorBS="attgtcatatcatctctccttcatatattgactagaggaTTT TACAtaaaatagaaagaGGTGTTACTATCAGAATAAGcaactgagattgataagtcac t" /listShort="rapG, phrG" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(3757457..3757476) /Source="Nicolas_upshift_promotors" /id="U3174" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.67032967032967" /psig="0.997002997002997" /xcortree=3164 /SigmaFactorBS="tgcgggtgcgatcttattcatgtgaaactcctttctcTAGTG ACTtatcaatctcagttGCTTATTCTGATAGTAACACctctttctattttatgtaaaa t" /listShort="S1549, yycN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3757457 /Source="Nicolas_upshifts" /id="U3173" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.551448551448551" /psig="0.995004995004995" /xcortree=3163 /SigmaFactorBS="attgtcatatcatctctccttcatatattgactagaggaTTT TACAtaaaatagaaagaGGTGTTACTATCAGAATAAGcaactgagattgataagtcac t" /listShort="rapG, phrG" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3757475) /Source="Nicolas_upshifts" /id="U3174" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.67032967032967" /psig="0.997002997002997" /xcortree=3164 /SigmaFactorBS="tgcgggtgcgatcttattcatgtgaaactcctttctcTAGTG ACTtatcaatctcagttGCTTATTCTGATAGTAACACctctttctattttatgtaaaa t" /listShort="S1549, yycN" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3757477..3757752) /Source="Nicolas_S_feature" /locus_tag="new_4140222_4140497_c" /HighExp="S4, S5, S6, S7, S8, S3, B36, BT, LoTm, T5.0H" /AntisenseName="rapG" /AntisenseCor="-0.20647217228472101" /AntisenseRegPval="-3.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1550" promotor_-35 complement(3757491..3757498) /Source="Nicolas_upshift_promotors" /id="U3174" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.67032967032967" /psig="0.997002997002997" /xcortree=3164 /SigmaFactorBS="tgcgggtgcgatcttattcatgtgaaactcctttctcTAGTG ACTtatcaatctcagttGCTTATTCTGATAGTAACACctctttctattttatgtaaaa t" /listShort="S1549, yycN" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3757515..3758612 /gene="rapG" /locus_tag="BSU_40300" /old_locus_tag="BSU40300" /EC_number="3.1.-.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12950930, 16553878" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12950930, 16553878; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="response regulator aspartate phosphatase" /protein_id="NP_391910.1" /db_xref="EnsemblGenomes-Gn:BSU40300" /db_xref="EnsemblGenomes-Tr:CAB16067" /db_xref="GOA:O32294" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="SubtiList:BG11466" /db_xref="UniProtKB/Swiss-Prot:O32294" /translation="MNKIAPAEIASMLNDWYLAIKKHEVEESSRLFEEVKPLLDDMEE DQEVLAYFSLLELRHKVLLHEARGQGFQHEEPSHMNATSDMLKYYFFLFEGMYEAYKN NYDIAIGLYKDAEQYLDNIPDPIEKAEFHLKVGKLYYKLGQNIVSLNHTRQAVKTFRE ETDYKKKLASALITMSGNFTEMSQFEEAEAYLDEAIRITSELEDHFFEAQLLHNFGLL HAQSGKSEEAVSKLEEALQNDEYARSAYYYHSAYLLIRELFKIKKKEQALSYYQDVKE KLTAEPNRICEAKIDILYAIYAEGGHAETFHLCKQHMDDLLSEKEYDSVRELSILAGE RYRELELYKEAAHFFYEALQIEELIKRTEVI*" /label="rapG CDS" gene 3757515..3758612 /gene="rapG" /locus_tag="BSU_40300" /old_locus_tag="BSU40300" /label="rapG gene" promotor_-10 complement(3757743..3757761) /Source="Nicolas_upshift_promotors" /id="U3175" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1127 /SigmaFactorBS="aggcctcatacatgccttcaaacagaaaaaaGTAATAtttca gcatgtcagACGTAGCATTCATATGAGAaggctcctcatgctgaaagccctgtcctct c" /listShort="S1550, S1549, yycN, yycO, yycP" /listLong="yycQ" /label="promotor_-10" upshifts complement(3757752) /Source="Nicolas_upshifts" /id="U3175" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1127 /SigmaFactorBS="aggcctcatacatgccttcaaacagaaaaaaGTAATAtttca gcatgtcagACGTAGCATTCATATGAGAaggctcctcatgctgaaagccctgtcctct c" /listShort="S1550, S1549, yycN, yycO, yycP" /listLong="yycQ" /label="upshifts" promotor_-35 complement(3757776..3757781) /Source="Nicolas_upshift_promotors" /id="U3175" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1127 /SigmaFactorBS="aggcctcatacatgccttcaaacagaaaaaaGTAATAtttca gcatgtcagACGTAGCATTCATATGAGAaggctcctcatgctgaaagccctgtcctct c" /listShort="S1550, S1549, yycN, yycO, yycP" /listLong="yycQ" /label="promotor_-35" promotor_-35 3758336..3758344 /Source="Nicolas_upshift_promotors" /id="U3176" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=523 /SigmaFactorBS="acaggccttatcttattaccaagacgtGAAGGAAAAattgac tgctgAGCCGAATAGAATATGTGAggcaaaaatagacattttatatgccatttatgca g" /listShort="phrG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3758356..3758374 /Source="Nicolas_upshift_promotors" /id="U3176" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=523 /SigmaFactorBS="acaggccttatcttattaccaagacgtGAAGGAAAAattgac tgctgAGCCGAATAGAATATGTGAggcaaaaatagacattttatatgccatttatgca g" /listShort="phrG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3758369 /Source="Nicolas_upshifts" /id="U3176" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=523 /SigmaFactorBS="acaggccttatcttattaccaagacgtGAAGGAAAAattgac tgctgAGCCGAATAGAATATGTGAggcaaaaatagacattttatatgccatttatgca g" /listShort="phrG" /GFF_Attribute="listLong" /label="upshifts" CDS 3758613..3758729 /gene="phrG" /locus_tag="BSU_40310" /old_locus_tag="BSU40310" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12950930, 16553878, 16816200" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12950930, 16553878, 16816200; Product type r: regulator" /codon_start=1 /transl_table=11 /product="secreted regulator of the activity of phosphatase RapG" /protein_id="NP_391911.1" /db_xref="EnsemblGenomes-Gn:BSU40310" /db_xref="EnsemblGenomes-Tr:CAB16068" /db_xref="InterPro:IPR030968" /db_xref="SubtiList:BG11465" /db_xref="UniProtKB/Swiss-Prot:O32295" /translation="MKRFLIGAGVAAVILSGWFIADHQTHSQEMKVAEKMIG*" /label="phrG CDS" gene 3758613..3758729 /gene="phrG" /locus_tag="BSU_40310" /old_locus_tag="BSU40310" /label="phrG gene" downshifts 3758718 /Source="Nicolas_upshifts" /id="D2085" /incds=0 /nref=39 /ntot=249 /MaxReadThrough="4.8963" /MaxDrop="7.30713" /score="31.0184314" /energy="-13.7" /TU="U3173,U3176" /idTUdmin="U3173" /TUdmin="-45" /isTUend="FALSE" /label="downshifts" CDS complement(3758966..3759856) /gene="argI" /locus_tag="BSU_40320" /old_locus_tag="BSU40320" /EC_number="3.5.3.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:104957, 4216455, 7540694, 10931887, 11418582, 12533460, 22720735, 23625224, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 104957, 4216455, 7540694, 10931887, 11418582, 12533460, 22720735, 23625224, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arginase" /protein_id="NP_391912.1" /db_xref="EnsemblGenomes-Gn:BSU40320" /db_xref="EnsemblGenomes-Tr:CAB16069" /db_xref="GOA:P39138" /db_xref="InterPro:IPR006035" /db_xref="InterPro:IPR014033" /db_xref="InterPro:IPR020855" /db_xref="InterPro:IPR023696" /db_xref="SubtiList:BG10932" /db_xref="UniProtKB/Swiss-Prot:P39138" /translation="MDKTISVIGMPMDLGQARRGVDMGPSAIRYAHLIERLSDMGYTV EDLGDIPINREKIKNDEELKNLNSVLAGNEKLAQKVNKVIEEKKFPLVLGGDHSIAIG TLAGTAKHYDNLGVIWYDAHGDLNTLETSPSGNIHGMPLAVSLGIGHESLVNLEGYAP KIKPENVVIIGARSLDEGERKYIKESGMKVYTMHEIDRLGMTKVIEETLDYLSACDGV HLSLDLDGLDPNDAPGVGTPVVGGISYRESHLAMEMLYDAGIITSAEFVEVNPILDHK NKTGKTAVELVESLLGKKLL*" /label="argI CDS" gene complement(3758966..3759856) /gene="argI" /locus_tag="BSU_40320" /old_locus_tag="BSU40320" /label="argI gene" downshifts complement(3758972) /Source="Nicolas_upshifts" /id="D2086" /incds=0 /nref=1 /ntot=40 /MaxReadThrough="3.33097" /MaxDrop="3.38667" /score="2.36475602" /energy="-13.7" /TU="U3177" /idTUdmin="U3177" /TUdmin="-89" /isTUend="FALSE" /label="downshifts" downshifts complement(3759034) /Source="Nicolas_upshifts" /id="D2087" /incds=1 /nref=28 /ntot=201 /MaxReadThrough="5.16507" /MaxDrop="5.79932" /score="2.36475602" /energy="-13.7" /TU="U3177" /idTUdmin="U3177" /TUdmin="-151" /isTUend="FALSE" /label="downshifts" CDS complement(3759930..3761333) /gene="rocE" /locus_tag="BSU_40330" /old_locus_tag="BSU40330" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7540694, 10648515, 15849754, 16850406, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7540694, 10648515, 15849754, 16850406, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="arginine/ornithine/gamma-aminobutyrate permease" /protein_id="NP_391913.1" /db_xref="EnsemblGenomes-Gn:BSU40330" /db_xref="EnsemblGenomes-Tr:CAB16070" /db_xref="GOA:P39137" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG10933" /db_xref="UniProtKB/Swiss-Prot:P39137" /translation="MNTNQDNGNQLQRTMKSRHLFMISLGGVIGTGFFLGTGFTINQA GPLGAVLSYLVGGFIMFLTMLCLGELAVAFPVSGSFQTYATKFISPAFGFAFGWLYWL GWAVTCAIEFLSAGQLMQRWFPHIDVWIWCLVFAALMFILNAITTKAFAESEFWFSGI KILIILLFIILGGAAMFGLIDLKGGEQAPFLTHFYEDGLFPNGIKAMLITMITVNFAF QGTELIGVAAGESEDPEKTIPRSIKQTVWRTLVFFVLSIIVIAGMIPWKQAGVVESPF VAVFEQIGIPYAADIMNFVILIALLSVANSGLYASTRILYAMANEGQAFKALGKTNQR GVPMYSLIVTMAVACLSLLTKFAQAETVYMVLLSLAGMSAQVGWITISLSQIMFRRKY IREGGKIEDLKFKTPLYPVLPLIGLTLNTVVLISLAFDPEQRIALYCGVPFMIICYII YHVVIKKRQQANRQLEL*" /label="rocE CDS" gene complement(3759930..3761333) /gene="rocE" /locus_tag="BSU_40330" /old_locus_tag="BSU40330" /label="rocE gene" S_feature complement(3761334..3761555) /Source="Nicolas_S_feature" /locus_tag="new_4144079_4144300_c" /HighExp="Lbstat, S0, LPh, T1.30H, HPh, T2.0H, LPhT, BI, M0t90, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigL" /TUshortPSig="0.884" /TUlongSig="NA" /TUlongPSig="NA" /label="S1551" CDS complement(3761556..3762761) /gene="rocD" /locus_tag="BSU_40340" /old_locus_tag="BSU40340" /EC_number="2.6.1.13" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7540694, 9383188, 22720735, 23869754" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7540694, 9383188, 22720735, 23869754; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ornithine aminotransferase" /protein_id="NP_391914.1" /db_xref="EnsemblGenomes-Gn:BSU40340" /db_xref="EnsemblGenomes-Tr:CAB16071" /db_xref="GOA:P38021" /db_xref="InterPro:IPR004636" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR010164" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR034757" /db_xref="SubtiList:BG10722" /db_xref="UniProtKB/Swiss-Prot:P38021" /translation="MTALSKSKEIIDQTSHYGANNYHPLPIVISEALGAWVKDPEGNE YMDMLSAYSAVNQGHRHPKIIQALKDQADKITLTSRAFHNDQLGPFYEKTAKLTGKEM ILPMNTGAEAVESAVKAARRWAYEVKGVADNQAEIIACVGNFHGRTMLAVSLSSEEEY KRGFGPMLPGIKLIPYGDVEALRQAITPNTAAFLFEPIQGEAGIVIPPEGFLQEAAAI CKEENVLFIADEIQTGLGRTGKTFACDWDGIVPDMYILGKALGGGVFPISCIAADREI LGVFNPGSHGSTFGGNPLACAVSIASLEVLEDEKLADRSLELGEYFKSELESIDSPVI KEVRGRGLFIGVELTEAARPYCERLKEEGLLCKETHDTVIRFAPPLIISKEDLDWAIE KIKHVLRNA*" /label="rocD CDS" gene complement(3761556..3762761) /gene="rocD" /locus_tag="BSU_40340" /old_locus_tag="BSU40340" /label="rocD gene" misc_feature complement(3762818..3762836) /Source="Nicolas_upshift_promotors" /id="U3177" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.884115884115884" /psig="0.884115884115884" /xcortree=390 /SigmaFactorBS="gcaccttgtcctcgaaaattgtagaaaacacacgaattcttg attTGGCACAGAACTTGCATTTatataaagggaaagcaggataacatgttgaaacaga a" /listShort="rocD, S1551, rocE, argI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3762821) /Source="Nicolas_upshifts" /id="U3177" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.884115884115884" /psig="0.884115884115884" /xcortree=390 /SigmaFactorBS="gcaccttgtcctcgaaaattgtagaaaacacacgaattcttg attTGGCACAGAACTTGCATTTatataaagggaaagcaggataacatgttgaaacaga a" /listShort="rocD, S1551, rocE, argI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3762931..3762936 /Source="Nicolas_upshift_promotors" /id="U3178" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.364635364635365" /psig="0.992007992007992" /xcortree=2367 /SigmaFactorBS="aaaatttcagcaagtgcaaaattctTTTGCAtatcctctccg tttTTTTATAAAATAGAAGCAATattaagaaaataattgagggaggttcatacagtgg t" /listShort="rocR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3762951..3762970 /Source="Nicolas_upshift_promotors" /id="U3178" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.364635364635365" /psig="0.992007992007992" /xcortree=2367 /SigmaFactorBS="aaaatttcagcaagtgcaaaattctTTTGCAtatcctctccg tttTTTTATAAAATAGAAGCAATattaagaaaataattgagggaggttcatacagtgg t" /listShort="rocR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3762966 /Source="Nicolas_upshifts" /id="U3178" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.364635364635365" /psig="0.992007992007992" /xcortree=2367 /SigmaFactorBS="aaaatttcagcaagtgcaaaattctTTTGCAtatcctctccg tttTTTTATAAAATAGAAGCAATattaagaaaataattgagggaggttcatacagtgg t" /listShort="rocR" /GFF_Attribute="listLong" /label="upshifts" CDS 3763002..3764387 /gene="rocR" /locus_tag="BSU_40350" /old_locus_tag="BSU40350" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9194709, 12533460, 12634342, 23869754" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9194709, 12533460, 12634342, 23869754; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (NtrC/NifA family)" /protein_id="NP_391915.1" /db_xref="EnsemblGenomes-Gn:BSU40350" /db_xref="EnsemblGenomes-Tr:CAB16072" /db_xref="GOA:P38022" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR002078" /db_xref="InterPro:IPR002197" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR025662" /db_xref="InterPro:IPR025943" /db_xref="InterPro:IPR025944" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR035965" /db_xref="SubtiList:BG10723" /db_xref="UniProtKB/Swiss-Prot:P38022" /translation="MVKDSEFLTLVFQSILDEIDVGLHVVDEHGNTIVYNNKMMQIED MEKHDVLNKNLMDVFMFSKQQDSTLVQALQEGKTIKNVKQSYFNNKGQEITTINHTYP IVQDGKIRGAVEIAKDVTKLERLIRENMNKKGSTTYTFDSILGTSPAIQDVIENAKRA TRTSSSVLLAGETGTGKELFAQSIHNGSDRSGGPFISQNCAALPDSLVESILFGTKKG AFTGAVDQPGLFEQAHGGTLLLDEINSLNLSLQAKLLRALQERKIRRIGSTKDTPIDV RIIATMNEDPIDAIAGERMRKDLYYRLSVVTLIIPPLRERKEDILLLASEFIQKNNHL FQMNVEHISDDVKQFFLSYDWPGNIRELEHMIEGAMNFMTDEQTITASHLPYQYRMKI KPADIPEPETPRHQPAADLKEKMESFEKYVIENVLRKHGHNISKAAQELGISRQSLQY RLKKFSHSSNE*" /label="rocR CDS" gene 3763002..3764387 /gene="rocR" /locus_tag="BSU_40350" /old_locus_tag="BSU40350" /label="rocR gene" CDS complement(3764369..3764557) /gene="yyzO" /locus_tag="BSU_40359" /old_locus_tag="BSU40359" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17198402; Product type r: regulator" /pseudo /codon_start=1 /transl_table=11 /product="fragment of putative sensor protein" /db_xref="PSEUDO:CAX52717.1" /translation="MFDRFYKADPSRSRKYGGSGLGLAITKSIIDNHNGTIEVKSEIG RGTVFLIRLPAPDYSLDE*" /label="yyzO CDS" gene complement(3764369..3764557) /gene="yyzO" /locus_tag="BSU_40359" /old_locus_tag="BSU40359" /pseudo /label="yyzO gene" CDS complement(3764674..3764802) /locus_tag="BSU_40358" /old_locus_tag="BSU40358" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514013.1" /translation="MPGCFDMQKKLNRGHARSVEKGYIEYEEKYKMDVTRETANGS*" /label="hypothetical protein CDS" gene complement(3764674..3764802) /locus_tag="BSU_40358" /old_locus_tag="BSU40358" /label="gene" downshifts 3764726 /Source="Nicolas_upshifts" /id="D2088" /incds=0 /nref=1 /ntot=146 /MaxReadThrough="0.86899" /MaxDrop="2.90385" /score="20.2816165" /energy="-10.8" /TU="NA" /idTUdmin="U3178" /TUdmin=110 /isTUend="FALSE" /label="downshifts" CDS complement(3764822..3766024) /gene="htrC" /locus_tag="BSU_40360" /old_locus_tag="BSU40360" /EC_number="3.4.21.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10692364, 11133960, 16030236, 25384476" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10692364, 11133960, 16030236, 25384476; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sporulation membrane serine protease" /protein_id="NP_391916.1" /db_xref="EnsemblGenomes-Gn:BSU40360" /db_xref="EnsemblGenomes-Tr:CAB16073" /db_xref="GOA:P39668" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR001940" /db_xref="InterPro:IPR009003" /db_xref="InterPro:IPR036034" /db_xref="SubtiList:BG11054" /db_xref="UniProtKB/Swiss-Prot:P39668" /translation="MVDYEREEEHTTPEQPKRSKKGYFLSSLIGVIVGAVLMAFIMPY LSNEGLDTGALDQQQNNNGRESIRTVNVSVNNAVTKIVSNMSPAVVGVVNIQKSDIWG ESGEAGSGSGVIYKKNDHSAYVVTNHHVIEGASQIEISLKDGSRVSADLVGSDQLMDL AVLRVKSDKIKAVADFGNSDKVKSGEPVIAIGNPLGLEFAGSVTQGVISGTERAIPVD SNGDGQPDWNAEVLQTDAAINPGNSGGALLNMDGKVIGINSMKIAESAVEGIGLSIPS KLVIPVIEDLERYGKVKRPFLGIEMKSLSDIASYHWDETLKLPKNVTNGAVVMGVDAF SPAGKAGLKELDVITEFDGYKVNDIVDLRKRLYQKKVGDRVKVKFYRGGKEKSVDIKL SSADQLGS*" /label="htrC CDS" gene complement(3764822..3766024) /gene="htrC" /locus_tag="BSU_40360" /old_locus_tag="BSU40360" /label="htrC gene" downshifts complement(3764846) /Source="Nicolas_upshifts" /id="D2089" /incds=0 /nref=134 /ntot=253 /MaxReadThrough="2.3073" /MaxDrop="5.06813" /score="5.6507537" /energy="-15" /TU="NA" /idTUdmin="U3179" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3766056..3766067) /Source="Nicolas_upshift_promotors" /id="U3179" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=815 /SigmaFactorBS="gcgctgtataatttttctatgtaaatcaTGACTATtctagga gtttctaACCCACAATATAaccatattaacgttcttggaaaggatggaatatggtgga t" /listShort="htrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3766056) /Source="Nicolas_upshifts" /id="U3179" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=815 /SigmaFactorBS="gcgctgtataatttttctatgtaaatcaTGACTATtctagga gtttctaACCCACAATATAaccatattaacgttcttggaaaggatggaatatggtgga t" /listShort="htrC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3766082..3766088) /Source="Nicolas_upshift_promotors" /id="U3179" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=815 /SigmaFactorBS="gcgctgtataatttttctatgtaaatcaTGACTATtctagga gtttctaACCCACAATATAaccatattaacgttcttggaaaggatggaatatggtgga t" /listShort="htrC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3766106..3766900) /gene="walJ" /locus_tag="BSU_40370" /old_locus_tag="BSU40370" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9829949, 16030236, 21169496; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_391917.2" /db_xref="EnsemblGenomes-Gn:BSU40370" /db_xref="EnsemblGenomes-Tr:CAB16074" /db_xref="GOA:C0SP91" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG11464" /db_xref="UniProtKB/Swiss-Prot:C0SP91" /translation="MSLQFSVLASGSTGNAFYLETEDHAFLVDAGLSGKAMDGLMAQI GRKLDDVDGIFVTHEHSDHIKGLGVVARKYKLPIYANEKTWKAMENQIGKIDTDQKFV FPMETVKSFGGLDVESFGVSHDAAEPMFYVFHYSGRKLALMTDTGYVSDRMKGIIRSA NVFVFESNHDVGMLQMGRYPWSIKRRILSDVGHVSNEDAALAMTDVIGDETSRIYLAH LSQDNNMKELARMSVQQTLASKGFVTGETFDLYDTDPKKATPLCAV*" /label="walJ CDS" gene complement(3766106..3766900) /gene="walJ" /locus_tag="BSU_40370" /old_locus_tag="BSU40370" /label="walJ gene" CDS complement(3766922..3767764) /gene="walI" /locus_tag="BSU_40380" /old_locus_tag="BSU40380" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16030236, 17307848, 17307850, 18408157, 21219466" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16030236, 17307848, 17307850, 18408157, 21219466; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of WalRK" /protein_id="NP_391918.1" /db_xref="EnsemblGenomes-Gn:BSU40380" /db_xref="EnsemblGenomes-Tr:CAB16075" /db_xref="GOA:Q45612" /db_xref="InterPro:IPR018604" /db_xref="PDB:2O3O" /db_xref="SubtiList:BG11463" /db_xref="UniProtKB/Swiss-Prot:Q45612" /translation="MEWNKTKSIFIVAFLILDIFLGYQFFQKWQATGKEYEVIKNDVE HDMKADHITYEGLNKEATEGYRITANQKSFSKEEIEALKDQKPLMDMPSDDHKVTSLK MKFANPIALSKKDIEDDAQALVSSKIQDGEKYKLWKVDKSKKEIIFFQTYEGHYIYQK TDNPSNMIGQVVLHLNGKNEVVSYDQTTLETFKQIQKESLITEMDAVELLYYQNQLKE YSTVKSCKFGYVAQYPLTSTQVLAPVWRITVEYEKKVNGEKKTVQEYFTVNALESTIL DTDQ*" /label="walI CDS" gene complement(3766922..3767764) /gene="walI" /locus_tag="BSU_40380" /old_locus_tag="BSU40380" /label="walI gene" CDS complement(3767751..3769118) /gene="walH" /locus_tag="Delta6_BSU_40390_SNPvariant" /old_locus_tag="BSU_40390" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16030236, 16600972, 17307850, 26999783" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16030236, 16600972, 17307850, 26999783; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of WalRK(YycFG)" /protein_id="NP_391919.1" /db_xref="EnsemblGenomes-Gn:BSU40390" /db_xref="EnsemblGenomes-Tr:CAB16076" /db_xref="GOA:Q794W0" /db_xref="InterPro:IPR009996" /db_xref="PDB:2FGT" /db_xref="SubtiList:BG11462" /db_xref="UniProtKB/Swiss-Prot:Q794W0" /modified_by="User" /translation="MKRENIKTILLTVLVVISLVFTWGIWTFQPNFSEGSSSTESTVR VKHKIEKTTQKLSETVRPRDMFIHDDGAHYKVDDNALYEEIWSDLPHWDVKGIKDISD QYDKAGFKSWFYGIGGSEAKLDLQFSDTIPIDIFQTLFKWSNQSFEYSSFDHILIPFN ETKANKKIYLVSYSKQLILEVTVESANYRNIMNDLKNRQSNMPAFSLFSIGSKKEFLL PNKPLTMDKKEFVTESIKTNTFKQALFSDPSIVREDSNYTNRNVLTDGISRLDVNLSQ RQVQFQQRNLVQSTSYQTGELIKKSQKYLEDTGSWTDHYQFFNINDSQQLSFYIFMDQ IPVINSTAKPFGATSAITVQWANDDILSYKRPNYSLGTNPIKTSETELMGGSEVKMLL SKQTAYDTDKIDQIFLAYQLVSTSTNDDPLVELEPVWAMKVNGKIVPITKDLLRKEGA NSGVE*" /label="Delta6_BSU_40390_SNPvariant" gene complement(3767751..3769118) /gene="walH" /locus_tag="Delta6_BSU_40390_SNPvariant" /old_locus_tag="BSU_40390" /modified_by="User" /label="Delta6_BSU_40390_SNPvariant" Polymorphism join(3768345,3768347) /Source="geneious" /ID="SNP_BsDelta6_4151091_4151091" /Polymorphism_Type="SNP (transversion)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change="N -> T" /CDS_Position=773 /Change="T -> G" /Codon_Change="AAC -> ACC" /Coverage=184 /locus_tag="BSU_40390" /Protein_Effect="Substitution" /Reference_Frequency="0.5%" /Reference_Nucleotides="T" /Variant_Nucleotides="G" /Variant_P_Value=0 /Variant_Raw_Frequency=183 /comment="Delta6_BSU_40390_SNPvariant" /modified_by="User" / /label="Polymorphism_Delta6" CDS complement(3769108..3770943) /gene="walK" /locus_tag="BSU_40400" /old_locus_tag="BSU40400" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10878122, 12682299, 15015732, 15153768, 17307850, 17370266, 19019149, 22751669" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10878122, 12682299, 15015732, 15153768, 17307850, 17370266, 19019149, 22751669; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YycG]" /protein_id="NP_391920.1" /db_xref="EnsemblGenomes-Gn:BSU40400" /db_xref="EnsemblGenomes-Tr:CAB16077" /db_xref="GOA:Q45614" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR000700" /db_xref="InterPro:IPR001610" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="PDB:3SL2" /db_xref="SubtiList:BG11461" /db_xref="UniProtKB/Swiss-Prot:Q45614" /translation="MNKVGFFRSIQFKITLIYVLLIIIAMQIIGVYFVNQVEKSLISS YEQSLNQRIDNLSYYIEQEYKSDNDSTVIKDDVSRILNDFTKSDEVREISFVDKSYEV VGSSKPYGEEVAGKQTTDLIFKRIFSTKQSYLRKYYDPKSKIRVLISAKPVMTENQEV VGAIYVVASMEDVFNQMKTINTILASGTGLALVLTALLGIFLARTITHPLSDMRKQAM ELAKGNFSRKVKKYGHDEIGQLATTFNHLTRELEDAQAMTEGERRKLASVIAYMTDGV IATNRNGAIILLNSPALELLNVSRETALEMPITSLLGLQENYTFEDLVEQQDSMLLEI ERDDELTVLRVNFSVIQREHGKIDGLIAVIYDVTEQEKMDQERREFVANVSHELRTPL TTMRSYLEALAEGAWENKDIAPRFLMVTQNETERMIRLVNDLLQLSKFDSKDYQFNRE WIQIVRFMSLIIDRFEMTKEQHVEFIRNLPDRDLYVEIDQDKITQVLDNIISNALKYS PEGGHVTFSIDVNEEEELLYISVKDEGIGIPKKDVEKVFDRFYRVDKARTRKLGGTGL GLAIAKEMVQAHGGDIWADSIEGKGTTITFTLPYKEEQEDDWDEA*" /label="walK CDS" gene complement(3769108..3770943) /gene="walK" /locus_tag="BSU_40400" /old_locus_tag="BSU40400" /label="walK gene" CDS complement(3770951..3771658) /gene="walR" /locus_tag="BSU_40410" /old_locus_tag="BSU40410" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10878122, 12682299, 15015732, 15153768, 17307850, 17370266, 18789936, 19019149, 21219466, 23199363, 24125693, 26102633, 28674376" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10878122, 12682299, 15015732, 15153768, 17307850, 17370266, 18789936, 19019149, 21219466, 23199363, 24125693, 26102633, 28674376; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YycF]" /protein_id="NP_391921.1" /db_xref="EnsemblGenomes-Gn:BSU40410" /db_xref="EnsemblGenomes-Tr:CAB16078" /db_xref="GOA:P37478" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="PDB:2D1V" /db_xref="PDB:2ZWM" /db_xref="PDB:3F6P" /db_xref="SubtiList:BG10001" /db_xref="UniProtKB/Swiss-Prot:P37478" /translation="MDKKILVVDDEKPIADILEFNLRKEGYEVHCAHDGNEAVEMVEE LQPDLILLDIMLPNKDGVEVCREVRKKYDMPIIMLTAKDSEIDKVIGLEIGADDYVTK PFSTRELLARVKANLRRQLTTAPAEEEPSSNEIHIGSLVIFPDAYVVSKRDETIELTH REFELLHYLAKHIGQVMTREHLLQTVWGYDYFGDVRTVDVTVRRLREKIEDNPSHPNW IVTRRGVGYYLRNPEQD*" /label="walR CDS" gene complement(3770951..3771658) /gene="walR" /locus_tag="BSU_40410" /old_locus_tag="BSU40410" /label="walR gene" S_feature complement(3771659..3771755) /Source="Nicolas_S_feature" /locus_tag="new_4154404_4154500_c" /HighExp="H2O2, G180, G150, Paraq, G135, Oxctl, dia0, LBGstat, dia5, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, Sig-" /TUshortPSig="1, 1, 0.11" /TUlongSig="SigA" /TUlongPSig="0.986" /label="S1552" promotor_-10 complement(3771743..3771762) /Source="Nicolas_upshift_promotors" /id="U3180" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.739260739260739" /psig=1 /xcortree=2526 /SigmaFactorBS="tgaaacatgtgttttttttctaaacctttattttTTTTatct tttgaccttaaACCGTTATAATAGACAAGGAcccattctttacatgggccataagtga t" /listShort="S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3771755) /Source="Nicolas_upshifts" /id="U3180" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.739260739260739" /psig=1 /xcortree=2526 /SigmaFactorBS="tgaaacatgtgttttttttctaaacctttattttTTTTatct tttgaccttaaACCGTTATAATAGACAAGGAcccattctttacatgggccataagtga t" /listShort="S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3771757..3771949) /Source="Nicolas_S_feature" /locus_tag="new_4154502_4154694_c" /HighExp="G180, Paraq, Oxctl, G135, G150, H2O2, T0.30H, BMM, Cold, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, Sig-" /TUshortPSig="0.986, 1, 0.11" /TUlongSig="NA" /TUlongPSig="NA" /label="S1553" promotor_-35 complement(3771778..3771781) /Source="Nicolas_upshift_promotors" /id="U3180" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.739260739260739" /psig=1 /xcortree=2526 /SigmaFactorBS="tgaaacatgtgttttttttctaaacctttattttTTTTatct tttgaccttaaACCGTTATAATAGACAAGGAcccattctttacatgggccataagtga t" /listShort="S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3771949) /Source="Nicolas_upshifts" /id="U3181" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97902097902098" /psig="0.986013986013986" /xcortree=2753 /SigmaFactorBS="tttttcttttaggaaaaaggcaaacatgaggAGTGTTATAAT AGAAGAAAAagggagaaccggccctgcggccggttcaaagaagaagacgtcattgata a" /listShort="S1553" /listLong="S1552, walR, walK, walH, yycI, yycJ, htrC" /label="upshifts" misc_feature complement(3771959..3771978) /Source="Nicolas_upshift_promotors" /id="U3181" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97902097902098" /psig="0.986013986013986" /xcortree=2753 /SigmaFactorBS="tttttcttttaggaaaaaggcaaacatgaggAGTGTTATAAT AGAAGAAAAagggagaaccggccctgcggccggttcaaagaagaagacgtcattgata a" /listShort="S1553" /listLong="S1552, walR, walK, walH, yycI, yycJ, htrC" /label="promotor_single_box" /note="Geneious type: promotor_single_box" downshifts complement(3772041) /Source="Nicolas_upshifts" /id="D2090" /incds=0 /nref=8 /ntot=83 /MaxReadThrough="5.21091" /MaxDrop="5.81799" /score="24.1725164" /energy="-10.6" /TU="U3183,U3184" /idTUdmin="U3181" /TUdmin="-264" /isTUend="FALSE" /label="downshifts" tRNA complement(3772042..3772114) /gene="trnY-Phe" /locus_tag="BSU_tRNA_1" /product="tRNA-Phe" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnY-Phe tRNA" gene complement(3772042..3772114) /gene="trnY-Phe" /locus_tag="BSU_tRNA_1" /label="trnY-Phe gene" tRNA complement(3772150..3772226) /gene="trnY-Asp" /locus_tag="BSU_tRNA_2" /product="tRNA-Asp" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnY-Asp tRNA" gene complement(3772150..3772226) /gene="trnY-Asp" /locus_tag="BSU_tRNA_2" /label="trnY-Asp gene" S_feature complement(3772227..3772307) /Source="Nicolas_S_feature" /locus_tag="new_4154972_4155052_c" /HighExp="Oxctl, Heat, BMM, Paraq, UNK1, H2O2, C30, MG 45, G180, MG 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0.11" /TUlongSig="NA" /TUlongPSig="NA" /label="S1554" tRNA complement(3772308..3772379) /gene="trnY-Glu" /locus_tag="BSU_tRNA_3" /product="tRNA-Glu" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnY-Glu tRNA" gene complement(3772308..3772379) /gene="trnY-Glu" /locus_tag="BSU_tRNA_3" /label="trnY-Glu gene" tRNA complement(3772389..3772464) /gene="trnY-Lys" /locus_tag="BSU_tRNA_4" /product="tRNA-Lys" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnY-Lys tRNA" gene complement(3772389..3772464) /gene="trnY-Lys" /locus_tag="BSU_tRNA_4" /label="trnY-Lys gene" misc_feature 3772436..3772452 /Source="Nicolas_upshift_promotors" /id="U3182" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.652347652347652" /psig="0.0739260739260739" /xcortree=1705 /SigmaFactorBS="tggtgagccatgaaggactcgaaccttcgaccctctgattaa aagtcAGATGCTCTACCAACTGagctaatggctcttaaagatgtcggaatttctatag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3772449 /Source="Nicolas_upshifts" /id="U3182" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.652347652347652" /psig="0.0739260739260739" /xcortree=1705 /SigmaFactorBS="tggtgagccatgaaggactcgaaccttcgaccctctgattaa aagtcAGATGCTCTACCAACTGagctaatggctcttaaagatgtcggaatttctatag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3772465..3772561) /Source="Nicolas_S_feature" /locus_tag="new_4155210_4155306_c" /HighExp="LBGstat, C30, UNK1, Oxctl, HPh, Heat, MG 150, BMM, Paraq, MG-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0.11" /TUlongSig="NA" /TUlongPSig="NA" /label="S1555" promotor_-10 complement(3772545..3772564) /Source="Nicolas_upshift_promotors" /id="U3183" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2627 /SigmaFactorBS="tctgagaaaaaaatatgaaaaaaaaccaaaaaagttATTGCC ACttctatttgttcgTGATATTATAAATCTCGTTGttacggaaactgcttcaatagag t" /listShort="S1555, trnY-Lys, trnY-Glu, S1554, trnY-Asp, trnY-Phe, S1553, S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3772561) /Source="Nicolas_upshifts" /id="U3183" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2627 /SigmaFactorBS="tctgagaaaaaaatatgaaaaaaaaccaaaaaagttATTGCC ACttctatttgttcgTGATATTATAAATCTCGTTGttacggaaactgcttcaatagag t" /listShort="S1555, trnY-Lys, trnY-Glu, S1554, trnY-Asp, trnY-Phe, S1553, S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3772578..3772585) /Source="Nicolas_upshift_promotors" /id="U3183" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2627 /SigmaFactorBS="tctgagaaaaaaatatgaaaaaaaaccaaaaaagttATTGCC ACttctatttgttcgTGATATTATAAATCTCGTTGttacggaaactgcttcaatagag t" /listShort="S1555, trnY-Lys, trnY-Glu, S1554, trnY-Asp, trnY-Phe, S1553, S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_no_box complement(3772595..3772696) /Source="Nicolas_upshift_promotors" /id="U3184" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.587412587412587" /psig="0.10989010989011" /xcortree=285 /SigmaFactorBS="cgaactaaatagaatatgtctgcaagcccctatttaaggggc ttgtttttgtttgaaagccgcatataagttggtctgagaaaaaaatatgaaaaaaaac c" /listShort="S1555, trnY-Lys, trnY-Glu, S1554, trnY-Asp, trnY-Phe, S1553, S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(3772635) /Source="Nicolas_upshifts" /id="U3184" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.587412587412587" /psig="0.10989010989011" /xcortree=285 /SigmaFactorBS="cgaactaaatagaatatgtctgcaagcccctatttaaggggc ttgtttttgtttgaaagccgcatataagttggtctgagaaaaaaatatgaaaaaaaac c" /listShort="S1555, trnY-Lys, trnY-Glu, S1554, trnY-Asp, trnY-Phe, S1553, S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3772689..3773981) /gene="purA" /locus_tag="BSU_40420" /old_locus_tag="BSU40420" /EC_number="6.3.4.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1312531, 10368157, 16163456, 21424839" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1312531, 10368157, 16163456, 21424839; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="adenylosuccinate synthetase" /protein_id="NP_391922.1" /db_xref="EnsemblGenomes-Gn:BSU40420" /db_xref="EnsemblGenomes-Tr:CAB16079" /db_xref="GOA:P29726" /db_xref="InterPro:IPR001114" /db_xref="InterPro:IPR018220" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR033128" /db_xref="SubtiList:BG10002" /db_xref="UniProtKB/Swiss-Prot:P29726" /translation="MSSVVVVGTQWGDEGKGKITDFLSENAEVIARYQGGNNAGHTIK FDGITYKLHLIPSGIFYKDKTCVIGNGMVVDPKALVTELAYLHERNVSTDNLRISNRA HVILPYHLKLDEVEEERKGANKIGTTKKGIGPAYMDKAARIGIRIADLLDRDAFAEKL ERNLEEKNRLLEKMYETEGFKLEDILDEYYEYGQQIKKYVCDTSVVLNDALDEGRRVL FEGAQGVMLDIDQGTYPFVTSSNPVAGGVTIGSGVGPTKIKHVVGVSKAYTTRVGDGP FPTELKDEIGDQIREVGREYGTTTGRPRRVGWFDSVVVRHARRVSGITDLSLNSIDVL AGIETLKICVAYRYKGEIIEEFPASLKALAECEPVYEEMPGWTEDITGAKSLSELPEN ARHYLERVSQLTGIPLSIFSVGPDRSQTNVLRSVYRAN*" /label="purA CDS" gene complement(3772689..3773981) /gene="purA" /locus_tag="BSU_40420" /old_locus_tag="BSU40420" /label="purA gene" downshifts complement(3772700) /Source="Nicolas_upshifts" /id="D2091" /incds=0 /nref=200 /ntot=241 /MaxReadThrough="2.03104" /MaxDrop="6.53551" /score="13.9967927" /energy="-10.5" /TU="NA" /idTUdmin="U3185" /TUdmin=1 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3774021..3774040) /Source="Nicolas_upshift_promotors" /id="U3185" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2426 /SigmaFactorBS="acgaatatagatttacaataaattaatgttcggatttacAAT TGACTttctgtttcttcacTGATAAACTTGATTTGTTTGaatagaatcgttttgaaag g" /listShort="purA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3774041) /Source="Nicolas_upshifts" /id="U3185" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2426 /SigmaFactorBS="acgaatatagatttacaataaattaatgttcggatttacAAT TGACTttctgtttcttcacTGATAAACTTGATTTGTTTGaatagaatcgttttgaaag g" /listShort="purA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3774055..3774062) /Source="Nicolas_upshift_promotors" /id="U3185" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2426 /SigmaFactorBS="acgaatatagatttacaataaattaatgttcggatttacAAT TGACTttctgtttcttcacTGATAAACTTGATTTGTTTGaatagaatcgttttgaaag g" /listShort="purA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3774187..3774606) /gene="yycE" /locus_tag="BSU_40430" /old_locus_tag="BSU40430" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16731985" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391923.1" /db_xref="EnsemblGenomes-Gn:BSU40430" /db_xref="EnsemblGenomes-Tr:CAB16080" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="PDB:1TWU" /db_xref="SubtiList:BG10003" /db_xref="UniProtKB/Swiss-Prot:P37479" /translation="MGKRFSSFQAAQIRIARPTGQLDEIIRFYEEGLCLKRIGEFSQH NGYDGVMFGLPHADYHLEFTQYEGGSTAPVPHPDSLLVFYVPNAVELAAITSKLKHMG YQEVESENPYWSNGGVTIEDPDGWRIVFMNSKGISGK*" /label="yycE CDS" gene complement(3774187..3774606) /gene="yycE" /locus_tag="BSU_40430" /old_locus_tag="BSU40430" /label="yycE gene" promotor_-10 complement(3774604..3774615) /Source="Nicolas_upshift_promotors" /id="U3186" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=870 /SigmaFactorBS="acgttcgctcagcggatgaaaaattgaaagcgttttaatAAA ATGGtgcaaaaaggagatGGTAACAATATGggaaaacgtttttcgtcttttcaagcag c" /listShort="yycE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3774615) /Source="Nicolas_upshifts" /id="U3186" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=870 /SigmaFactorBS="acgttcgctcagcggatgaaaaattgaaagcgttttaatAAA ATGGtgcaaaaaggagatGGTAACAATATGggaaaacgtttttcgtcttttcaagcag c" /listShort="yycE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3774630..3774636) /Source="Nicolas_upshift_promotors" /id="U3186" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=870 /SigmaFactorBS="acgttcgctcagcggatgaaaaattgaaagcgttttaatAAA ATGGtgcaaaaaggagatGGTAACAATATGggaaaacgtttttcgtcttttcaagcag c" /listShort="yycE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3774727..3776091) /gene="dnaC" /locus_tag="BSU_40440" /old_locus_tag="BSU40440" /EC_number="3.6.4.12" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:7711902, 10844689, 12682299, 12718886, 16002087, 19744498, 23563155, 25713353" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7711902, 10844689, 12682299, 12718886, 16002087, 19744498, 23563155, 25713353; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="replicative DNA helicase" /protein_id="NP_391924.2" /db_xref="EnsemblGenomes-Gn:BSU40440" /db_xref="EnsemblGenomes-Tr:CAB16081" /db_xref="GOA:P37469" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR007692" /db_xref="InterPro:IPR007693" /db_xref="InterPro:IPR007694" /db_xref="InterPro:IPR016136" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036185" /db_xref="SubtiList:BG10004" /db_xref="UniProtKB/Swiss-Prot:P37469" /translation="MTDLLNDRLPPQNIEAEQAVLGAIFLQPSALTLASEVLIPDDFY RMSHQKIYNAMLVLGDRGEPVDLVTVTSELANTDLLEEVGGISYLTDIANSVPTAANI EYYAKIVEEKSILRRLIRTATTIAQDGYTREDEVEDLLSEAEKTIMEVAQRKNTSAFQ NIKDVLVQTYDNIEQLHNRKGDITGIPTGFTELDRMTAGFQRNDLIIVAARPSVGKTA FALNIAQNVATKTDESVAIFSLEMGAEQLVMRMLCAEGNINAQNLRTGNLTEEDWGKL TMAMGSLSNSGIYIDDTPGIRVSEIRAKCRRLKQESGLGMILIDYLQLIQGSGRSKDN RQQEVSEISRELKSIARELQVPVIALSQLSRGVEQRQDKRPMMSDIRESGSIEQDADI VAFLYRDDYYDKETENKNIIEIIIAKQRNGPVGTVSLAFVKEYNKFVNLERRFDDAGV PPGA*" /label="dnaC CDS" gene complement(3774727..3776091) /gene="dnaC" /locus_tag="BSU_40440" /old_locus_tag="BSU40440" /label="dnaC gene" downshifts complement(3774747) /Source="Nicolas_upshifts" /id="D2092" /incds=0 /nref=3 /ntot=107 /MaxReadThrough="1.37092" /MaxDrop="3.96365" /score="31.6981667" /energy="-12.6" /TU="NA" /idTUdmin="U3187" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(3774791) /Source="Nicolas_upshifts" /id="D2093" /incds=1 /nref=9 /ntot=190 /MaxReadThrough="3.89737" /MaxDrop="3.21735" /score="31.6981667" /energy="-12.6" /TU="U3187" /idTUdmin="U3190" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3776122..3776141) /Source="Nicolas_upshift_promotors" /id="U3187" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=2596 /SigmaFactorBS="tctgctaactgaaaaaaacaggaaacagacaatttttcTATt ttttttctgtagaAATGGTAGAATGGAGGTTGGagattttttaatgagaggacggtgc t" /listShort="dnaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3776136) /Source="Nicolas_upshifts" /id="U3187" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=2596 /SigmaFactorBS="tctgctaactgaaaaaaacaggaaacagacaatttttcTATt ttttttctgtagaAATGGTAGAATGGAGGTTGGagattttttaatgagaggacggtgc t" /listShort="dnaC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3776156..3776158) /Source="Nicolas_upshift_promotors" /id="U3187" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=2596 /SigmaFactorBS="tctgctaactgaaaaaaacaggaaacagacaatttttcTATt ttttttctgtagaAATGGTAGAATGGAGGTTGGagattttttaatgagaggacggtgc t" /listShort="dnaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3776203..3776209 /Source="Nicolas_upshift_promotors" /id="U3188" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=184 /SigmaFactorBS="tgtctgtttcctgtttttttcagttagcagattggatCGTTT CGgacagtaacaaggcGGGAAAAATGCAATAAAACataagggaggaatgaaagatgat a" /listShort="yycD, S1556" /listLong="yycC, S1558, yycB" /label="promotor_-35" promotor_-10 3776224..3776242 /Source="Nicolas_upshift_promotors" /id="U3188" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=184 /SigmaFactorBS="tgtctgtttcctgtttttttcagttagcagattggatCGTTT CGgacagtaacaaggcGGGAAAAATGCAATAAAACataagggaggaatgaaagatgat a" /listShort="yycD, S1556" /listLong="yycC, S1558, yycB" /label="promotor_-10" upshifts 3776226 /Source="Nicolas_upshifts" /id="U3188" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=184 /SigmaFactorBS="tgtctgtttcctgtttttttcagttagcagattggatCGTTT CGgacagtaacaaggcGGGAAAAATGCAATAAAACataagggaggaatgaaagatgat a" /listShort="yycD, S1556" /listLong="yycC, S1558, yycB" /label="upshifts" CDS 3776261..3776461 /gene="yycD" /locus_tag="BSU_40450" /old_locus_tag="BSU40450" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11717295" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391925.1" /db_xref="EnsemblGenomes-Gn:BSU40450" /db_xref="EnsemblGenomes-Tr:CAB16082" /db_xref="InterPro:IPR018691" /db_xref="InterPro:IPR020086" /db_xref="SubtiList:BG10005" /db_xref="UniProtKB/Swiss-Prot:P37480" /translation="MIKKYAITPNVDADGWFIEVENVAPTALYTSKDAAIEKAKQVAK ENSPSKLVIYDQFKNVEEEHSF*" /label="yycD CDS" gene 3776261..3776461 /gene="yycD" /locus_tag="BSU_40450" /old_locus_tag="BSU40450" /label="yycD gene" downshifts 3776431 /Source="Nicolas_upshifts" /id="D2094" /incds=0 /nref=15 /ntot=43 /MaxReadThrough="4.45045" /MaxDrop="5.68737" /score="12.3008592" /energy="-9.5" /TU="U3188" /idTUdmin="U3188" /TUdmin="-352" /isTUend="FALSE" /label="downshifts" S_feature 3776476..3776797 /Source="Nicolas_S_feature" /locus_tag="new_4159220_4159541" /HighExp="Etha, C30, Salt, S6, S8, M9-stat, S7, Oxctl, Paraq, Heat" /AntisenseName="yyzB" /AntisenseCor="0.309580857935493" /AntisenseRegPval="-6.7" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1556" CDS complement(3776509..3776712) /gene="yyzB" /locus_tag="BSU_40460" /old_locus_tag="BSU40460" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391926.1" /db_xref="EnsemblGenomes-Gn:BSU40460" /db_xref="EnsemblGenomes-Tr:CAB16083" /db_xref="SubtiList:BG14171" /db_xref="UniProtKB/Swiss-Prot:O32296" /translation="MHAPLSLLKQMLKEHQIDTEKAVTFEEYIAMRLKLQELMGKFAS IGEWDLYQKAADLMMHIGIQWMK*" /label="yyzB CDS" gene complement(3776509..3776712) /gene="yyzB" /locus_tag="BSU_40460" /old_locus_tag="BSU40460" /label="yyzB gene" S_feature complement(3776713..3777013) /Source="Nicolas_S_feature" /locus_tag="new_4159457_4159757_c" /HighExp="S6, S8, S7, S5, S4, BT, B36, T5.0H, S3, C30" /AntisenseName="yycC" /AntisenseCor="-0.77379453158709499" /AntisenseRegPval="-54.1" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.049" /TUlongSig="NA" /TUlongPSig="NA" /label="S1557" promotor_-35 3776778..3776781 /Source="Nicolas_upshift_promotors" /id="U3189" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.912087912087912" /psig=1 /xcortree=2150 /SigmaFactorBS="cggtcattttccgattgctctattcctttgtgacatcttCTT AcatttcacatctgaTTCTTGTACAATGGACAGAAgagaggagggatcttttgtgaga c" /listShort="yycC, S1558, yycB, yycA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3776796..3776815 /Source="Nicolas_upshift_promotors" /id="U3189" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.912087912087912" /psig=1 /xcortree=2150 /SigmaFactorBS="cggtcattttccgattgctctattcctttgtgacatcttCTT AcatttcacatctgaTTCTTGTACAATGGACAGAAgagaggagggatcttttgtgaga c" /listShort="yycC, S1558, yycB, yycA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3776799 /Source="Nicolas_upshifts" /id="U3189" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.912087912087912" /psig=1 /xcortree=2150 /SigmaFactorBS="cggtcattttccgattgctctattcctttgtgacatcttCTT AcatttcacatctgaTTCTTGTACAATGGACAGAAgagaggagggatcttttgtgaga c" /listShort="yycC, S1558, yycB, yycA" /GFF_Attribute="listLong" /label="upshifts" CDS 3776833..3776973 /gene="yycC" /locus_tag="BSU_40470" /old_locus_tag="BSU40470" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 28546427" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391927.1" /db_xref="EnsemblGenomes-Gn:BSU40470" /db_xref="EnsemblGenomes-Tr:CAB16084" /db_xref="InterPro:IPR025550" /db_xref="SubtiList:BG10006" /db_xref="UniProtKB/Swiss-Prot:P37481" /translation="MRPLQISAETAQKLAESLNLPLEQIMHMPQHILLAKMAELQKED KS*" /label="yycC CDS" gene 3776833..3776973 /gene="yycC" /locus_tag="BSU_40470" /old_locus_tag="BSU40470" /label="yycC gene" S_feature 3776974..3777045 /Source="Nicolas_S_feature" /locus_tag="new_4159718_4159789" /HighExp="Sw, LoTm, Gly, BC, HiOs, B60, S0, T-5.40H, LBGstat, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigB" /TUlongPSig=1 /label="S1558" upshifts complement(3777021) /Source="Nicolas_upshifts" /id="U3190" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.935064935064935" /psig="0.048951048951049" /xcortree=1271 /SigmaFactorBS="aaatgattggatttttttattatgtggatgtGGCAAagcagt tACTCCTCTTTTCTAAcatatacatgatattatcccgaaacaggtaagcaagtatgtg a" /listShort="S1557, yyzB, dnaC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3777024..3777038) /Source="Nicolas_upshift_promotors" /id="U3190" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.935064935064935" /psig="0.048951048951049" /xcortree=1271 /SigmaFactorBS="aaatgattggatttttttattatgtggatgtGGCAAagcagt tACTCCTCTTTTCTAAcatatacatgatattatcccgaaacaggtaagcaagtatgtg a" /listShort="S1557, yyzB, dnaC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3777046..3777050) /Source="Nicolas_upshift_promotors" /id="U3190" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.935064935064935" /psig="0.048951048951049" /xcortree=1271 /SigmaFactorBS="aaatgattggatttttttattatgtggatgtGGCAAagcagt tACTCCTCTTTTCTAAcatatacatgatattatcccgaaacaggtaagcaagtatgtg a" /listShort="S1557, yyzB, dnaC" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3777046..3778254 /gene="yycB" /locus_tag="BSU_40480" /old_locus_tag="BSU40480" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 25790494; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative anion ABC transporter (permease)" /protein_id="NP_391928.1" /db_xref="EnsemblGenomes-Gn:BSU40480" /db_xref="EnsemblGenomes-Tr:CAB16085" /db_xref="GOA:P37482" /db_xref="InterPro:IPR004747" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10007" /db_xref="UniProtKB/Swiss-Prot:P37482" /translation="MPHPHNKKIQSFWLITGIIFIAFNLRPAITSVGPVISSIRAELH MSNGAAGFLTALPLLSFAVLSPLAPKLGQRLGNERTLWLGLVILLIGVLTRSTGYTAA LFFGTALIGVGIAIGNVLLPSLIKHKYPEKPGIMISLYTTSMNIFAALASGVSVPLAT QMNGGWKQAFLLWGGLALLALLIWIPQLRHRDTANQTMKLQSSSIWASKMAWYVTIFM GLQSFLFYSSIAWFPEILRSHGIDTATAGWMVSLMQFASLPSTFLTPVLADRVKQQRG IVAALASVYLIGLCGLLAGGSHTLLAIWMIIIGIGQGSSISLALTLIGLRSENAQQAA ALSGMSQSFGYLLAAVGPIFVGYLFDQTHSWTMPIVLLIAALIVMGAAGQGAGRDRYI FQSEKQRNSA*" /label="yycB CDS" gene 3777046..3778254 /gene="yycB" /locus_tag="BSU_40480" /old_locus_tag="BSU40480" /label="yycB gene" downshifts 3778235 /Source="Nicolas_upshifts" /id="D2095" /incds=0 /nref=148 /ntot=242 /MaxReadThrough="3.65611" /MaxDrop="4.91246" /score="26.443484" /energy="-10.1" /TU="U3189" /idTUdmin="U3189" /TUdmin="-484" /isTUend="FALSE" /label="downshifts" CDS 3778359..3780416 /gene="yycA" /locus_tag="BSU_40490" /old_locus_tag="BSU40490" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 20512483; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyl transferase" /protein_id="NP_391929.2" /db_xref="EnsemblGenomes-Gn:BSU40490" /db_xref="EnsemblGenomes-Tr:CAB16086" /db_xref="GOA:P37483" /db_xref="SubtiList:BG10008" /db_xref="UniProtKB/Swiss-Prot:P37483" /translation="MKTKRFDAALILILLAAAFLNTYHIWQDDTANQYYLAAVKSMTQ SFHNFFYASFDPSGFVTVDKPPVVLWIQTIFALIFGVHTWSVIIPQALAGVGSVFLLY RMVKPTFGVGAARIAALVMALTPIAVAVSRTNNIDSMLVFTLLLGSTCLLRAVKQGKL VWLLTAFALIGLAFNMKMMQAFMVLPAFVLFYLIASRVSLKKKIGSLLLSLVLLTGLS LSWAIAVDSASSSSRPYVGSSQTNSVLELAFGYNGTERLFGQTTGLAKGDMNAAGGGN MQNQDNMQAPNGNGSSFSQNGNQSFGNHSQAPQPPNGQTGALNGGGGTPPTGGNGPGN GGPGGGGGKSVNMFGTGDPGPLRLFQSALSGQISWMLPFSLIGLLGAIISWYRDRRGH AAKMKETLFWAAWLVPVAGFFSIAGFFHQYYLIMLAPPIAALSGIGWYTMHRLYKNNK DWSSYLLPAAVLITAVFQVYILSAYTSQIGSVWMYVLGLLGLGITLALLMLKRSHPFS KLLTIISLCVLLLTPVYWSATPLLYGGNSVLPESGPQLKGSANGGNMFSSEVDSGLLS YLRKHNTGEEYLFATLTTVTAAPYIIYENESVMAMGGFNGTDPILTVSELKKLIKEGK VKYFLLSENNSGNSELVSWIKKNGKEITSDEYSGSSSSTNSVQGMRRGPGGESQQTLY LVE*" /label="yycA CDS" gene 3778359..3780416 /gene="yycA" /locus_tag="BSU_40490" /old_locus_tag="BSU40490" /label="yycA gene" downshifts 3780281 /Source="Nicolas_upshifts" /id="D2096" /incds=1 /nref=43 /ntot=203 /MaxReadThrough="1.96363" /MaxDrop="3.65354" /score="19.8733078" /energy="-16.6" /TU="NA" /idTUdmin="U3189" /TUdmin=1562 /isTUend="FALSE" /label="downshifts" CDS complement(3780453..3780902) /gene="rplI" /locus_tag="BSU_40500" /old_locus_tag="BSU40500" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9000630, 9588797, 11399077, 12682299, 14586115, 23002217" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9000630, 9588797, 11399077, 12682299, 14586115, 23002217; Product type f : factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L9" /protein_id="NP_391930.1" /db_xref="EnsemblGenomes-Gn:BSU40500" /db_xref="EnsemblGenomes-Tr:CAB16087" /db_xref="GOA:P37437" /db_xref="InterPro:IPR000244" /db_xref="InterPro:IPR009027" /db_xref="InterPro:IPR020069" /db_xref="InterPro:IPR020070" /db_xref="InterPro:IPR020594" /db_xref="InterPro:IPR036791" /db_xref="InterPro:IPR036935" /db_xref="SubtiList:BG10009" /db_xref="UniProtKB/Swiss-Prot:P37437" /translation="MKVIFLQDVKGKGKKGEVKNVADGYAHNFLIKKGLAVEANASNI SALNGQKQKEKKEAIAELEQAKSLKETLEKLTVELSAKSGEGGRLFGSVTSKQITEQL QKDHNIKVDKRKLELPDGIRALGYTNVPVKLHPEVQAVLKVHVKEEA*" /label="rplI CDS" gene complement(3780453..3780902) /gene="rplI" /locus_tag="BSU_40500" /old_locus_tag="BSU40500" /label="rplI gene" downshifts complement(3780467) /Source="Nicolas_upshifts" /id="D2097" /incds=0 /nref=231 /ntot=266 /MaxReadThrough="2.69721" /MaxDrop="6.57383" /score="44.1169256" /energy="-16.6" /TU="NA" /idTUdmin="U3191" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3780899..3782878) /gene="gdpP" /locus_tag="BSU_40510" /old_locus_tag="BSU40510" /EC_number="3.1.4.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:19901023, 19553197, 21257773, 21566650, 24465894, 24680501, 25616256, 26240071, 27150552, 28069645" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19901023, 19553197, 21257773, 21566650, 24465894, 24680501, 25616256, 26240071, 27150552, 28069645; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphodiesterase acting on cyclic dinucleotides" /protein_id="NP_391931.1" /db_xref="EnsemblGenomes-Gn:BSU40510" /db_xref="EnsemblGenomes-Tr:CAB16088" /db_xref="GOA:P37484" /db_xref="InterPro:IPR000160" /db_xref="InterPro:IPR001667" /db_xref="InterPro:IPR003156" /db_xref="InterPro:IPR014528" /db_xref="SubtiList:BG10010" /db_xref="UniProtKB/Swiss-Prot:P37484" /translation="MPSFYEKPLFRYPIYALIALSIITILISFYFNWILGTVEVLLLA VILFFIKRADSLIRQEIDAYISTLSYRLKKVGEEALMEMPIGIMLFNDQYYIEWANPF LSSCFNESTLVGRSLYDTCESVVPLIKQEVESETVTLNDRKFRVVIKRDERLLYFFDV TEQIQIEKLYENERTVLAYIFLDNYDDVTQGLDDQTRSTMNSQVTSLLNAWAQEYGIF LKRTSSERFIAVLNEHILTELENSKFSILDEVREKTSFDGVALTLSVGVGASVSSLKE LGDLAQSSLDLALGRGGDQVAIKLPNGKVKFYGGKTNPMEKRTRVRARVISHALKEIV TESSNVIIMGHKFPDMDSIGAAIGILKVAQANNKDGFIVIDPNQIGSSVQRLIGEIKK YEELWSRFITPEEAMEISNDDTLLVIVDTHKPSLVMEERLVNKIEHIVVIDHHRRGEE FIRDPLLVYMEPYASSTAELVTELLEYQPKRLKINMIEATALLAGIIVDTKSFSLRTG SRTFDAASYLRAKGADTVLVQKFLKETVDSYIKRAKLIQHTVLYKDNIAIASLPENEE EYFDQVLIAQAADSLLSMSEVEASFAVARRDEQTVCISARSLGEVNVQIIMEALEGGG HLTNAATQLSGISVSEALERLKHAIDEYFEGGVQR*" /label="gdpP CDS" gene complement(3780899..3782878) /gene="gdpP" /locus_tag="BSU_40510" /old_locus_tag="BSU40510" /label="gdpP gene" misc_feature complement(3781380..3781399) /Source="Nicolas_upshift_promotors" /id="U3191" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.454545454545455" /psig="0.997002997002997" /xcortree=2666 /SigmaFactorBS="cgaagcgcttaaaaatcaatatgattgaagcaacagccctat taGCTGGTATAATAGTGGATACaaagagcttttctctccgcacgggctcgcggacttt c" /listShort="rplI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3781383) /Source="Nicolas_upshifts" /id="U3191" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.454545454545455" /psig="0.997002997002997" /xcortree=2666 /SigmaFactorBS="cgaagcgcttaaaaatcaatatgattgaagcaacagccctat taGCTGGTATAATAGTGGATACaaagagcttttctctccgcacgggctcgcggacttt c" /listShort="rplI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3781796..3781803 /Source="Nicolas_upshift_promotors" /id="U3192" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2818 /SigmaFactorBS="acgataaaaccatctttgttatttgcctgagccacCTTTAAA AtcccgatcgctgcGCCGATAGAATCCATGTCGgggaatttatgccccatgataatca c" /listShort="S1559" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3781817..3781835 /Source="Nicolas_upshift_promotors" /id="U3192" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2818 /SigmaFactorBS="acgataaaaccatctttgttatttgcctgagccacCTTTAAA AtcccgatcgctgcGCCGATAGAATCCATGTCGgggaatttatgccccatgataatca c" /listShort="S1559" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3781821..3782487 /Source="Nicolas_S_feature" /locus_tag="new_4164565_4165231" /HighExp="LBGstat, C30, Cold, GM 10, GM 25, GM 15, GM-0.1, GM 45, GM 120, GM 90" /AntisenseName="yybT" /AntisenseCor="0.145393098609886" /AntisenseRegPval="-1.8" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1559" upshifts 3781821 /Source="Nicolas_upshifts" /id="U3192" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2818 /SigmaFactorBS="acgataaaaccatctttgttatttgcctgagccacCTTTAAA AtcccgatcgctgcGCCGATAGAATCCATGTCGgggaatttatgccccatgataatca c" /listShort="S1559" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3782915..3783844) /gene="yybS" /locus_tag="BSU_40520" /old_locus_tag="BSU40520" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22956758; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391932.1" /db_xref="EnsemblGenomes-Gn:BSU40520" /db_xref="EnsemblGenomes-Tr:CAB16089" /db_xref="InterPro:IPR018710" /db_xref="SubtiList:BG10011" /db_xref="UniProtKB/Swiss-Prot:P37485" /translation="MKQTRALMEGAILISLFAIITLLVVYVPVIGTILLFALPLPMIL YTIRHGLKLGIWMGAVSLPVVFIVGSFNGLIVAFMSACAGIAMGHFFKRKEPGHAIIS GALIYMLSIVFYFVISIQFLGINIIDEAMTQYRQSLDIVETVAKQSGNAGQFEKQLKL MEEQLGIVQYLFPTAIVMVGVIFSFLSYLIAKPLLRRFSPDIPNLKPFRELKFPQSVV VLYLIIVMLSFLPLEKGQMLYSIALNGEFILGFLIFIQGLSFIFFYCHKKQYPKAAAV IAVILGFVHPVFMAAIRILGVLDMGFHIRNKVK*" /label="yybS CDS" gene complement(3782915..3783844) /gene="yybS" /locus_tag="BSU_40520" /old_locus_tag="BSU40520" /label="yybS gene" S_feature complement(3783845..3783981) /Source="Nicolas_S_feature" /locus_tag="new_4166589_4166725_c" /HighExp="H2O2, G150, G180, Cold, Paraq, G135, Oxctl, Salt, Etha, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1560" promotor_-10 complement(3783963..3783982) /Source="Nicolas_upshift_promotors" /id="U3193" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.416583416583417" /psig=1 /xcortree=2490 /SigmaFactorBS="cttttcctttttcatgtttcacatgaaacattagcgtcaTTT TACttgcgatttggactTATGTTAAAATATAAAAGTAaaatttagagatgatataaaa a" /listShort="S1560, yybS, yybT, rplI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3783981) /Source="Nicolas_upshifts" /id="U3193" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.416583416583417" /psig=1 /xcortree=2490 /SigmaFactorBS="cttttcctttttcatgtttcacatgaaacattagcgtcaTTT TACttgcgatttggactTATGTTAAAATATAAAAGTAaaatttagagatgatataaaa a" /listShort="S1560, yybS, yybT, rplI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3783997..3784002) /Source="Nicolas_upshift_promotors" /id="U3193" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.416583416583417" /psig=1 /xcortree=2490 /SigmaFactorBS="cttttcctttttcatgtttcacatgaaacattagcgtcaTTT TACttgcgatttggactTATGTTAAAATATAAAAGTAaaatttagagatgatataaaa a" /listShort="S1560, yybS, yybT, rplI" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3784071..3784220) /gene="yyzH" /locus_tag="BSU_40529" /old_locus_tag="BSU40529" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097802.1" /db_xref="EnsemblGenomes-Gn:BSU40529" /db_xref="EnsemblGenomes-Tr:CAX52718" /db_xref="GOA:C0H3U2" /db_xref="UniProtKB/Swiss-Prot:C0H3U2" /translation="MWDMIKNFFLFSSGVLQATTLLLVILIFMYVRKTKKKNKESSGF MDDKH*" /label="yyzH CDS" gene complement(3784071..3784220) /gene="yyzH" /locus_tag="BSU_40529" /old_locus_tag="BSU40529" /label="yyzH gene" downshifts complement(3784097) /Source="Nicolas_upshifts" /id="D2098" /incds=0 /nref=1 /ntot=44 /MaxReadThrough="6.98636" /MaxDrop="3.23568" /score="-6.7107279" /energy="-8.4" /TU="U3194" /idTUdmin="U3197" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3784259..3784278) /Source="Nicolas_upshift_promotors" /id="U3194" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=247 /SigmaFactorBS="catatcagcatatgcccaacgctcaatgttgttcatgaTGTT TTGaagtttttaaaaaGGGAAATTCACCTTATATAGgatacgggttgagaacatgcac a" /listShort="yyzH, S1560, yybS, yybT" /listLong="rplI" /label="promotor_-10" upshifts complement(3784276) /Source="Nicolas_upshifts" /id="U3194" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=247 /SigmaFactorBS="catatcagcatatgcccaacgctcaatgttgttcatgaTGTT TTGaagtttttaaaaaGGGAAATTCACCTTATATAGgatacgggttgagaacatgcac a" /listShort="yyzH, S1560, yybS, yybT" /listLong="rplI" /label="upshifts" promotor_-35 complement(3784292..3784298) /Source="Nicolas_upshift_promotors" /id="U3194" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=247 /SigmaFactorBS="catatcagcatatgcccaacgctcaatgttgttcatgaTGTT TTGaagtttttaaaaaGGGAAATTCACCTTATATAGgatacgggttgagaacatgcac a" /listShort="yyzH, S1560, yybS, yybT" /listLong="rplI" /label="promotor_-35" promotor_-35 3784299..3784308 /Source="Nicolas_upshift_promotors" /id="U3195" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1292 /SigmaFactorBS="ggtgaatttccctttttaaaaacttcaaaacaTCATGAACAA cattgagcgttgGGCATATGCTGATATGGAATctgatcgataaaggagaattttcaca t" /listShort="cotF, S1562, ppaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3784321..3784340 /Source="Nicolas_upshift_promotors" /id="U3195" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1292 /SigmaFactorBS="ggtgaatttccctttttaaaaacttcaaaacaTCATGAACAA cattgagcgttgGGCATATGCTGATATGGAATctgatcgataaaggagaattttcaca t" /listShort="cotF, S1562, ppaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3784327 /Source="Nicolas_upshifts" /id="U3195" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1292 /SigmaFactorBS="ggtgaatttccctttttaaaaacttcaaaacaTCATGAACAA cattgagcgttgGGCATATGCTGATATGGAATctgatcgataaaggagaattttcaca t" /listShort="cotF, S1562, ppaC" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3784339) /Source="Nicolas_upshifts" /id="U3196" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=698 /SigmaFactorBS="tttcatgccaagccaatgttctgcgttcaTCCATgtgaaaat TCTCCTTTATCGATCagattccatatcagcatatgcccaacgctcaatgttgttcatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3784341..3784854) /Source="Nicolas_S_feature" /locus_tag="new_4167085_4167598_c" /HighExp="dia5, Diami, H2O2, Salt, dia15, Etha, Paraq, LPhT, G180, C30" /AntisenseName="cotF" /AntisenseCor="-0.33406696665100499" /AntisenseRegPval="-7.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1561" promotor_-10 complement(3784343..3784357) /Source="Nicolas_upshift_promotors" /id="U3196" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=698 /SigmaFactorBS="tttcatgccaagccaatgttctgcgttcaTCCATgtgaaaat TCTCCTTTATCGATCagattccatatcagcatatgcccaacgctcaatgttgttcatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3784366..3784370) /Source="Nicolas_upshift_promotors" /id="U3196" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=698 /SigmaFactorBS="tttcatgccaagccaatgttctgcgttcaTCCATgtgaaaat TCTCCTTTATCGATCagattccatatcagcatatgcccaacgctcaatgttgttcatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3784366..3784848 /gene="cotF" /locus_tag="BSU_40530" /old_locus_tag="BSU40530" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:1708381, 19933362, 23335421" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1708381, 19933362, 23335421; Product type s: structure" /codon_start=1 /transl_table=11 /product="spore coat protein" /protein_id="NP_391933.1" /db_xref="EnsemblGenomes-Gn:BSU40530" /db_xref="EnsemblGenomes-Tr:CAB16090" /db_xref="GOA:P23261" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR012851" /db_xref="InterPro:IPR016493" /db_xref="SubtiList:BG10012" /db_xref="UniProtKB/Swiss-Prot:P23261" /translation="MDERRTLAWHETLEMHELVAFQSNGLIKLKKMIREVKDPQLRQL YNVSIQGVEQNLRELLPFFPQAPHREDEEEERADNPFYSGDLLGFAKTSVRSYAIAIT ETATPQLRNVLVKQLNAAIQLHAQVYRYMYQHGYYPSYNLSELLKNDVRNANRAISMK *" /label="cotF CDS" gene 3784366..3784848 /gene="cotF" /locus_tag="BSU_40530" /old_locus_tag="BSU40530" /label="cotF gene" downshifts 3784835 /Source="Nicolas_upshifts" /id="D2099" /incds=0 /nref=20 /ntot=52 /MaxReadThrough="5.45774" /MaxDrop="4.1869" /score="-3.60126456" /energy="-16.9" /TU="U3195" /idTUdmin="U3195" /TUdmin="-1540" /isTUend="FALSE" /label="downshifts" CDS complement(3784878..3785255) /gene="hypR" /locus_tag="BSU_40540" /old_locus_tag="BSU40540" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:22238377" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22238377; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (Cys-activated by oxidative stress)" /protein_id="NP_391934.1" /db_xref="EnsemblGenomes-Gn:BSU40540" /db_xref="EnsemblGenomes-Tr:CAB16091" /db_xref="GOA:P37486" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:4A5M" /db_xref="PDB:4A5N" /db_xref="SubtiList:BG10013" /db_xref="UniProtKB/Swiss-Prot:P37486" /translation="MSEKKNIYPNKEGCPVEFTLDVIGGKWKGILFYHMIDGKKRFNE FRRICPSITQRMLTLQLRELEADGIVHREVYHQVPPKVEYSLTEFGRTLEPIVLQMKE WGESNRDVLESYRSNGLVKDQQK*" /label="hypR CDS" gene complement(3784878..3785255) /gene="hypR" /locus_tag="BSU_40540" /old_locus_tag="BSU40540" /label="hypR gene" S_feature 3784880..3785409 /Source="Nicolas_S_feature" /locus_tag="new_4167624_4168153" /HighExp="S8, S6, S7, BT, S5, B36, C30, B60, G/S, Pyr" /AntisenseName="yybR" /AntisenseCor="-0.26586375565089998" /AntisenseRegPval="-5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1562" downshifts complement(3784899) /Source="Nicolas_upshifts" /id="D2100" /incds=0 /nref=124 /ntot=240 /MaxReadThrough="4.32896" /MaxDrop="5.38963" /score="10.6464065" /energy="-15.3" /TU="U3197" /idTUdmin="U3197" /TUdmin="-802" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3785310..3785329) /Source="Nicolas_upshift_promotors" /id="U3197" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.776223776223776" /psig="0.997002997002997" /xcortree=1958 /SigmaFactorBS="cccttaaaaattgatgtgaataagaagcatttTCTTTGAGct aaggagaaaagGTGTGTAAAATACTGGGTAGattagttgcaaaatgtaatgtagtatc a" /listShort="yybR, S1561, yyzH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3785322) /Source="Nicolas_upshifts" /id="U3197" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.776223776223776" /psig="0.997002997002997" /xcortree=1958 /SigmaFactorBS="cccttaaaaattgatgtgaataagaagcatttTCTTTGAGct aaggagaaaagGTGTGTAAAATACTGGGTAGattagttgcaaaatgtaatgtagtatc a" /listShort="yybR, S1561, yyzH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3785343..3785350) /Source="Nicolas_upshift_promotors" /id="U3197" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.776223776223776" /psig="0.997002997002997" /xcortree=1958 /SigmaFactorBS="cccttaaaaattgatgtgaataagaagcatttTCTTTGAGct aaggagaaaagGTGTGTAAAATACTGGGTAGattagttgcaaaatgtaatgtagtatc a" /listShort="yybR, S1561, yyzH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3785391..3785395 /Source="Nicolas_upshift_promotors" /id="U3198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=2340 /SigmaFactorBS="aaatgcttcttattcacatcaatttttaagggtttgcatgAT TACacctgcagcaagaCGTGTTAAACTATATAAAGAttacactacttaaaaaaggata g" /listShort="ppaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3785409..3785428 /Source="Nicolas_upshift_promotors" /id="U3198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=2340 /SigmaFactorBS="aaatgcttcttattcacatcaatttttaagggtttgcatgAT TACacctgcagcaagaCGTGTTAAACTATATAAAGAttacactacttaaaaaaggata g" /listShort="ppaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3785411 /Source="Nicolas_upshifts" /id="U3198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=2340 /SigmaFactorBS="aaatgcttcttattcacatcaatttttaagggtttgcatgAT TACacctgcagcaagaCGTGTTAAACTATATAAAGAttacactacttaaaaaaggata g" /listShort="ppaC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3785436..3785450) /Source="Nicolas_upshift_promotors" /id="U3199" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.553446553446553" /psig="0.393606393606394" /xcortree=309 /SigmaFactorBS="tatctgggttttggtgtccgaaaataagtatctttTcCATga tagctccTATCCTTTTTTAAGTagtgtaatctttatatagtttaacacgtcttgctgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3785439) /Source="Nicolas_upshifts" /id="U3199" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.553446553446553" /psig="0.393606393606394" /xcortree=309 /SigmaFactorBS="tatctgggttttggtgtccgaaaataagtatctttTcCATga tagctccTATCCTTTTTTAAGTagtgtaatctttatatagtttaacacgtcttgctgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 3785460..3786389 /gene="ppaC" /locus_tag="BSU_40550" /old_locus_tag="BSU40550" /EC_number="3.6.1.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9782505, 12682299, 15044829, 17611193, 9782505, 21749987, 22938038" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9782505, 12682299, 15044829, 17611193, 9782505, 21749987, 22938038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="inorganic pyrophosphatase (Mn2+-dependent)" /protein_id="NP_391935.1" /db_xref="EnsemblGenomes-Gn:BSU40550" /db_xref="EnsemblGenomes-Tr:CAB16092" /db_xref="GOA:P37487" /db_xref="InterPro:IPR001667" /db_xref="InterPro:IPR004097" /db_xref="InterPro:IPR022934" /db_xref="PDB:1K23" /db_xref="PDB:1WPM" /db_xref="PDB:1WPN" /db_xref="PDB:2HAW" /db_xref="PDB:2IW4" /db_xref="SubtiList:BG10014" /db_xref="UniProtKB/Swiss-Prot:P37487" /translation="MEKILIFGHQNPDTDTICSAIAYADLKNKLGFNAEPVRLGQVNG ETQYALDYFKQESPRLVETAANEVNGVILVDHNERQQSIKDIEEVQVLEVIDHHRIAN FETAEPLYYRAEPVGCTATILNKMYKENNVKIEKEIAGLMLSAIISDSLLFKSPTCTD QDVAAAKELAEIAGVDAEEYGLNMLKAGADLSKKTVEELISLDAKEFTLGSKKVEIAQ VNTVDIEDVKKRQAELEAVISKVVAEKNLDLFLLVITDILENDSLALAIGNEAAKVEK AFNVTLENNTALLKGVVSRKKQVVPVLTDAMAE*" /label="ppaC CDS" gene 3785460..3786389 /gene="ppaC" /locus_tag="BSU_40550" /old_locus_tag="BSU40550" /label="ppaC gene" downshifts 3786375 /Source="Nicolas_upshifts" /id="D2101" /incds=0 /nref=235 /ntot=270 /MaxReadThrough="2.06965" /MaxDrop="8.02492" /score="25.8885382" /energy="-11.7" /TU="NA" /idTUdmin="U3195" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(3786418) /Source="Nicolas_upshifts" /id="D2102" /incds=0 /nref=14 /ntot=136 /MaxReadThrough="1.08899" /MaxDrop="4.94065" /score="19.3488922" /energy="-11.7" /TU="NA" /idTUdmin="U3200" /TUdmin=33 /isTUend="FALSE" /label="downshifts" CDS complement(3786422..3786868) /gene="yybP" /locus_tag="BSU_40560" /old_locus_tag="BSU40560" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15096624, 25794618, 25794619; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative manganese-binding lipoprotein" /protein_id="NP_391936.1" /db_xref="EnsemblGenomes-Gn:BSU40560" /db_xref="EnsemblGenomes-Tr:CAB16093" /db_xref="GOA:P37488" /db_xref="SubtiList:BG10015" /db_xref="UniProtKB/Swiss-Prot:P37488" /translation="MKIILTVLAGVGLLSAGGCGMLDQVNDGLNYTSEAAGYVEKVKT FAEEAPELAEKAVNDTEAKEKLEAQLESIQKAAADFNELTPPDAAAEIHRTIQEHNET LQKSAEDVLKQAEEGKVSLKELEQSDLVQNAKQITDVMGQIEKLGE*" /label="yybP CDS" gene complement(3786422..3786868) /gene="yybP" /locus_tag="BSU_40560" /old_locus_tag="BSU40560" /label="yybP gene" S_feature complement(3786869..3787199) /Source="Nicolas_S_feature" /locus_tag="new_4169613_4169943_c" /HighExp="S8, Cold, S7, S6, H2O2, S5, S4, Etha, G180, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.998614" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1563" misc_RNA complement(3787058..3787175) /gene="mswM" /locus_tag="BSU_misc_RNA_94" /product="manganese ion binding riboswitch" /experiment="publication(s) with functional evidences, PMID:25794618, 25794619" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25794618, 25794619; Product type n: RNA" /label="mswM RNA" gene complement(3787058..3787175) /gene="mswM" /locus_tag="BSU_misc_RNA_94" /label="mswM gene" promotor_-10 complement(3787190..3787209) /Source="Nicolas_upshift_promotors" /id="U3200" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.743256743256743" /psig=1 /xcortree=672 /SigmaFactorBS="cacagcgcgcttttatataaacggcaggAATTTGACtggaac agatcggTGCTTTAGAATGAAAGTAATaaaaatgaacactccaaaggggagtagcttt c" /listShort="S1563, yybP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3787198) /Source="Nicolas_upshifts" /id="U3200" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.743256743256743" /psig=1 /xcortree=672 /SigmaFactorBS="cacagcgcgcttttatataaacggcaggAATTTGACtggaac agatcggTGCTTTAGAATGAAAGTAATaaaaatgaacactccaaaggggagtagcttt c" /listShort="S1563, yybP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3787223..3787230) /Source="Nicolas_upshift_promotors" /id="U3200" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.743256743256743" /psig=1 /xcortree=672 /SigmaFactorBS="cacagcgcgcttttatataaacggcaggAATTTGACtggaac agatcggTGCTTTAGAATGAAAGTAATaaaaatgaacactccaaaggggagtagcttt c" /listShort="S1563, yybP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3787236..3787242 /Source="Nicolas_upshift_promotors" /id="U3201" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=178 /SigmaFactorBS="tttcattctaaagcaccgatctgttccagtcaaattcctgcC GTTTATataaaagcgcgctgTGGTATTTAAAATTTGAATggtttttctatcaggagat c" /listShort="yybO" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3787255 /Source="Nicolas_upshifts" /id="U3201" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=178 /SigmaFactorBS="tttcattctaaagcaccgatctgttccagtcaaattcctgcC GTTTATataaaagcgcgctgTGGTATTTAAAATTTGAATggtttttctatcaggagat c" /listShort="yybO" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3787257..3787275 /Source="Nicolas_upshift_promotors" /id="U3201" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=178 /SigmaFactorBS="tttcattctaaagcaccgatctgttccagtcaaattcctgcC GTTTATataaaagcgcgctgTGGTATTTAAAATTTGAATggtttttctatcaggagat c" /listShort="yybO" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 3787271..3787277 /Source="Nicolas_upshift_promotors" /id="U3202" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.58941058941059" /psig="0.58941058941059" /xcortree=736 /SigmaFactorBS="ttatataaaagcgcgctgtggtatttaaaattTGAATGGttt ttctatcaggaGATCATGCTATGacagaggaggttttcatcatgagtcaagagcgcgt g" /listShort="yybO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3787292..3787303 /Source="Nicolas_upshift_promotors" /id="U3202" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.58941058941059" /psig="0.58941058941059" /xcortree=736 /SigmaFactorBS="ttatataaaagcgcgctgtggtatttaaaattTGAATGGttt ttctatcaggaGATCATGCTATGacagaggaggttttcatcatgagtcaagagcgcgt g" /listShort="yybO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3787299 /Source="Nicolas_upshifts" /id="U3202" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.58941058941059" /psig="0.58941058941059" /xcortree=736 /SigmaFactorBS="ttatataaaagcgcgctgtggtatttaaaattTGAATGGttt ttctatcaggaGATCATGCTATGacagaggaggttttcatcatgagtcaagagcgcgt g" /listShort="yybO" /GFF_Attribute="listLong" /label="upshifts" CDS 3787301..3788608 /gene="yybO" /locus_tag="BSU_40570" /old_locus_tag="BSU40570" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_391937.1" /db_xref="EnsemblGenomes-Gn:BSU40570" /db_xref="EnsemblGenomes-Tr:CAB16094" /db_xref="GOA:P37489" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10016" /db_xref="UniProtKB/Swiss-Prot:P37489" /translation="MTEEVFIMSQERVKRPGHTRWYISSLLSGIIILNYFDRVAISVA APAIQDSFHLTATELGIVFSIYTYSYTLMQLPVGSLLDRFGVAWVTRVGMTIWSFLTI LLAFLQGKLLLYLFRFLIGLTSASAFPAASKATALWFPPSERGLANSLFDSAAKFSNV IGAPLVAFLVTTFDWRVAFLTIGCINVLFTIFFWQYYEQPERHKRISKSELNYIQKHN AITTEQIPYKTGPLLKKLFTNRKVWGLMIGFTGYGYTFNLLLTWLPTFFKHTYGMDLM SSGLFTAVPWLISTISGIAVGGWLVDYFIKKGYPNTKVYRTVIIVGMSFGFFFLGSIL TNNITVAIICISIGLAGISATAPVGWSISAELAPIGSVSMLSSMVNLANNLFGGIIAA SLTGYLFDVTGSFTLSFLVAGFVLLLGLVFYVFVLGDVKRIKL*" /label="yybO CDS" gene 3787301..3788608 /gene="yybO" /locus_tag="BSU_40570" /old_locus_tag="BSU40570" /label="yybO gene" downshifts complement(3788409) /Source="Nicolas_upshifts" /id="D2103" /incds=1 /nref=1 /ntot=11 /MaxReadThrough="0.73662" /MaxDrop="2.97868" /score="30.543563" /energy="-17.9" /TU="NA" /idTUdmin="U3203" /TUdmin=264 /isTUend="FALSE" /label="downshifts" downshifts 3788597 /Source="Nicolas_upshifts" /id="D2104" /incds=0 /nref=7 /ntot=55 /MaxReadThrough="2.76545" /MaxDrop="3.99898" /score="-3.44083304" /energy="-17.9" /TU="NA" /idTUdmin="U3201" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3788652..3788891) /gene="yyzI" /locus_tag="BSU_40573" /old_locus_tag="BSU40573" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:CAX52719.1" /translation="MNYKKQNQGFGSISGDHNDIHDILATIEENGTQDAFHYEGGLQG KNEQVLEQIEQEMLASGLDIEEQDEEKVNGDGPIL*" /label="yyzI CDS" gene complement(3788652..3788891) /gene="yyzI" /locus_tag="BSU_40573" /old_locus_tag="BSU40573" /pseudo /label="yyzI gene" downshifts complement(3788673) /Source="Nicolas_upshifts" /id="D2105" /incds=0 /nref=4 /ntot=114 /MaxReadThrough="3.05613" /MaxDrop="4.69729" /score="30.543563" /energy="-17.9" /TU="NA" /idTUdmin="U3203" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_no_box complement(3788677..3788777) /Source="Nicolas_upshift_promotors" /id="U3203" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.552447552447552" /psig="0.010989010989011" /xcortree=1485 /SigmaFactorBS="gaaggtggtcttcaaggaaaaaacgagcaggtgctcgaacag atagagcaggaaatgctagcttcggggcttgatatagaggaacaggacgaggagaagg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(3788717) /Source="Nicolas_upshifts" /id="U3203" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.552447552447552" /psig="0.010989010989011" /xcortree=1485 /SigmaFactorBS="gaaggtggtcttcaaggaaaaaacgagcaggtgctcgaacag atagagcaggaaatgctagcttcggggcttgatatagaggaacaggacgaggagaagg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3788881..3789045) /gene="yyzJ" /locus_tag="BSU_40574" /old_locus_tag="BSU40574" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:CAX52720.1" /translation="MMIRGIHLEQQLKDIISACDVAIQNEDFDTLMNYYSERIMCKPR KQPPQRFCEL*" /label="yyzJ CDS" gene complement(3788881..3789045) /gene="yyzJ" /locus_tag="BSU_40574" /old_locus_tag="BSU40574" /pseudo /label="yyzJ gene" CDS complement(3789057..3789242) /locus_tag="BSU_40576" /old_locus_tag="BSU40576" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514014.1" /translation="MSHQTKYPVNEAAIMPSNRLFARFTMELSMDTEPIGASSAEMDQ RNRKNKNEKDPYVSNIV*" /label="hypothetical protein CDS" gene complement(3789057..3789242) /locus_tag="BSU_40576" /old_locus_tag="BSU40576" /label="gene" downshifts 3789323 /Source="Nicolas_upshifts" /id="D2106" /incds=0 /nref=13 /ntot=90 /MaxReadThrough="0.18425" /MaxDrop="3.85413" /score="3.91893698" /energy="-13.7" /TU="NA" /idTUdmin="U3201" /TUdmin=726 /isTUend="FALSE" /label="downshifts" CDS complement(3789515..3789661) /gene="yyzK" /locus_tag="BSU_40578" /old_locus_tag="BSU40578" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:CAX52721.1" /translation="MYGKTIKKRLEKIAFLFQEISKKRKEKIERSFVGSKQLHGLSYR RFRG*" /label="yyzK CDS" gene complement(3789515..3789661) /gene="yyzK" /locus_tag="BSU_40578" /old_locus_tag="BSU40578" /pseudo /label="yyzK gene" CDS complement(3789643..3789792) /gene="yyzL" /locus_tag="BSU_40579" /old_locus_tag="BSU40579" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:CAX52722.1" /translation="MLNQHTLTYSTIDRKDYRSYKSNPEICLRILHKINETPESRYSV CMAKP*" /label="yyzL CDS" gene complement(3789643..3789792) /gene="yyzL" /locus_tag="BSU_40579" /old_locus_tag="BSU40579" /pseudo /label="yyzL gene" misc_feature complement(3790108..3790124) /Source="Nicolas_upshift_promotors" /id="U3204" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.330669330669331" /psig="0.761238761238761" /xcortree=650 /SigmaFactorBS="agattaactatattatatcttaactgtaataacctgtaaaga attttattgatagtattggATTTTATGTTATAAAGGaaaaagggtgggcgatttgctc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3790125) /Source="Nicolas_upshifts" /id="U3204" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.330669330669331" /psig="0.761238761238761" /xcortree=650 /SigmaFactorBS="agattaactatattatatcttaactgtaataacctgtaaaga attttattgatagtattggATTTTATGTTATAAAGGaaaaagggtgggcgatttgctc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3790144..3790151 /Source="Nicolas_upshift_promotors" /id="U3205" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2295 /SigmaFactorBS="ttcctttataacataaaatccaatactatcaataaaatTCTT TACAggttattacagttaAGATATAATATAGTTAATCTtttacgtaaaaggaggtttt t" /listShort="S1564, yybN, S1565, yybM, yybL, yybK, yybJ, S1567" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3790166..3790369 /Source="Nicolas_S_feature" /locus_tag="new_4172910_4173113" /HighExp="nit, T-3.40H, T-1.40H, T-0.40H, T0.0H, SMMPr, SMM, LoTm, ferm, T-4.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1564" promotor_-10 3790166..3790185 /Source="Nicolas_upshift_promotors" /id="U3205" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2295 /SigmaFactorBS="ttcctttataacataaaatccaatactatcaataaaatTCTT TACAggttattacagttaAGATATAATATAGTTAATCTtttacgtaaaaggaggtttt t" /listShort="S1564, yybN, S1565, yybM, yybL, yybK, yybJ, S1567" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3790166 /Source="Nicolas_upshifts" /id="U3205" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2295 /SigmaFactorBS="ttcctttataacataaaatccaatactatcaataaaatTCTT TACAggttattacagttaAGATATAATATAGTTAATCTtttacgtaaaaggaggtttt t" /listShort="S1564, yybN, S1565, yybM, yybL, yybK, yybJ, S1567" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(3790187..3790201) /Source="Nicolas_upshift_promotors" /id="U3206" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.997002997002997" /psig=0 /xcortree=295 /SigmaFactorBS="tggggagatggagttactcctatttaaaacttcaacacaagt aataaaaaCCTCCTTTTACGTAAaagattaactatattatatcttaactgtaataacc t" /listShort="yyzL, yyzK" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3790191) /Source="Nicolas_upshifts" /id="U3206" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.997002997002997" /psig=0 /xcortree=295 /SigmaFactorBS="tggggagatggagttactcctatttaaaacttcaacacaagt aataaaaaCCTCCTTTTACGTAAaagattaactatattatatcttaactgtaataacc t" /listShort="yyzL, yyzK" /GFF_Attribute="listLong" /label="upshifts" CDS 3790370..3790807 /gene="yybN" /locus_tag="BSU_40580" /old_locus_tag="BSU40580" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 27902860" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391938.1" /db_xref="EnsemblGenomes-Gn:BSU40580" /db_xref="EnsemblGenomes-Tr:CAB16095" /db_xref="InterPro:IPR020208" /db_xref="SubtiList:BG10017" /db_xref="UniProtKB/Swiss-Prot:P37490" /translation="MNKFLKSNFRFLLAAALGISLLASSNFIKASNDNYKFHLLVPYG YGNAYSNDAFRQTTHTDNPWKVNLQKSAEGKGTIMTFWLINTGNSKIPKASKIHNVKQ GSGAHYYHANSQGSHTYVALAVENNNYSASSYGIDGVWDEETW*" /label="yybN CDS" gene 3790370..3790807 /gene="yybN" /locus_tag="BSU_40580" /old_locus_tag="BSU40580" /label="yybN gene" S_feature 3790808..3790884 /Source="Nicolas_S_feature" /locus_tag="new_4173552_4173628" /HighExp="M9-tran, SMMPr, MG 120, aero, GM 120, SMM, T-2.40H, T-4.40H, nit, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1565" downshifts 3790841 /Source="Nicolas_upshifts" /id="D2107" /incds=0 /nref=10 /ntot=98 /MaxReadThrough="6.91942" /MaxDrop="3.8662" /score="9.16494325" /energy="-9.5" /TU="U3205" /idTUdmin="U3201" /TUdmin=2244 /isTUend="FALSE" /label="downshifts" CDS 3790921..3791676 /gene="yybM" /locus_tag="BSU_40590" /old_locus_tag="BSU40590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter permease subunit" /protein_id="NP_391939.1" /db_xref="EnsemblGenomes-Gn:BSU40590" /db_xref="EnsemblGenomes-Tr:CAB16096" /db_xref="SubtiList:BG10018" /db_xref="UniProtKB/Swiss-Prot:P37491" /translation="MESHIYRIIKNKLTIIIFTIIILIPCVDISLLLMTNTEYHPAYA FFLSGTSVGHASQMILLWFLPLYFLLLCADDSIQDYKTGYHYILISKVGRKKYCLEKI FTSFIISFLTMFLSLILNFLLVQVFFFKGTFKNDLDQIKFPDNSLYTFSMAHPYIAIV LFSIICCIMSGFVGALGSSLSLLFRDKKYAYPASFFIWFVLILKNKSLMFLFQPFTEY GYNVLLPILCLSIFIFLIIISSIVLYEAKYNEN*" /label="yybM CDS" gene 3790921..3791676 /gene="yybM" /locus_tag="BSU_40590" /old_locus_tag="BSU40590" /label="yybM gene" S_feature complement(3791516..3794105) /Source="Nicolas_S_feature" /locus_tag="new_4174260_4176850_c" /HighExp="S8, S6, S4, S5, S7, S3, C30, BT, G135, T5.0H" /AntisenseName="yybK" /AntisenseCor="-0.46686696237140402" /AntisenseRegPval="-15.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1566" CDS 3791666..3792376 /gene="yybL" /locus_tag="BSU_40600" /old_locus_tag="BSU40600" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative transporter permease subunit" /protein_id="NP_391940.1" /db_xref="EnsemblGenomes-Gn:BSU40600" /db_xref="EnsemblGenomes-Tr:CAB16097" /db_xref="SubtiList:BG10019" /db_xref="UniProtKB/Swiss-Prot:P37492" /translation="MKIKRLLLILCLLLFLVTLWFNQNHTYLGKNSIASLLYMNNSTF GYSSIFAYTLFYIVPFLMLLSNFFHSENPYKVMRMVKRKNYYKSKIMEIGFVSLLFSS IHTVINITCTHIFFSKNLLVEANFLSICLLNMISLVFFYLSVGIMFRLTYDLFNSVAL AIFIVYIILDSLYFGVKLLLPNGYWEPFRDLAIFTNMLNRYWSTSNLIIVYIRQIIIV FIFYLVGSSIFLNKDYKK*" /label="yybL CDS" gene 3791666..3792376 /gene="yybL" /locus_tag="BSU_40600" /old_locus_tag="BSU40600" /label="yybL gene" downshifts 3791875 /Source="Nicolas_upshifts" /id="D2108" /incds=1 /nref=1 /ntot=11 /MaxReadThrough="7.39982" /MaxDrop="2.95139" /score="9.16494325" /energy="-9.5" /TU="U3205" /idTUdmin="U3205" /TUdmin="-2354" /isTUend="FALSE" /label="downshifts" CDS 3792373..3793128 /gene="yybK" /locus_tag="BSU_40610" /old_locus_tag="BSU40610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative transporter permease subunit" /protein_id="NP_391941.1" /db_xref="EnsemblGenomes-Gn:BSU40610" /db_xref="EnsemblGenomes-Tr:CAB16098" /db_xref="InterPro:IPR024295" /db_xref="SubtiList:BG10020" /db_xref="UniProtKB/Swiss-Prot:P37493" /translation="MRIKGFFITLVAIIFQASLSSYNNNKNVFPFLDGIPISTSGHYE YQNILLWFVPIVSLSFCFSGSIRDTYISYEQLKLVREHSRVKWVTSQFLIITVVLLIF TLSQIAIFYIYSLVSLHNLDINSVINKRFVMMTLMYYLTLLNLFSFQLFMELYYKSQI AQLNISVYIIFSLILAKKLVQLNSPKVIHYFLIPNYSNGLRTGLSYYSQSGTAIIEPL LGLFIIIILQISIVILSVLKFKKIDMLKSEGLQ*" /label="yybK CDS" gene 3792373..3793128 /gene="yybK" /locus_tag="BSU_40610" /old_locus_tag="BSU40610" /label="yybK gene" CDS 3793125..3793780 /gene="yybJ" /locus_tag="BSU_40620" /old_locus_tag="BSU40620" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 1938973; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ATP-binding cassette subunit of transporter" /protein_id="NP_391942.1" /db_xref="EnsemblGenomes-Gn:BSU40620" /db_xref="EnsemblGenomes-Tr:CAB16099" /db_xref="GOA:P37494" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10021" /db_xref="UniProtKB/Swiss-Prot:P37494" /translation="MIEVLNLTKKLKRLQF*IISLIHLKKEQFMDYLGVMVLERPCYF VHYPG**SLLKGV*LLKVNNYIKISLFLKV*D*L*KICSYFLSMMLLLTLKFCQKLKR SHQIMIY*ILLVELVWKILIV*RLVNSR*E*NND*ILHRLFLKNLIYCYLMNQQMRLM KKELHLFMTFFYKRKKGELPLLLLVITRKILYLYVTLH*K*IMDV*KLQKK*YIRKIV " /label="yybJ CDS" gene 3793125..3793780 /gene="yybJ" /locus_tag="BSU_40620" /old_locus_tag="BSU40620" /label="yybJ gene" S_feature 3793781..3794095 /Source="Nicolas_S_feature" /locus_tag="new_4176526_4176840" /HighExp="aero, Cold, HPh, nit, M/G, M9-tran, S1, SMM, LPh, T-4.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1567" downshifts 3794052 /Source="Nicolas_upshifts" /id="D2109" /incds=0 /nref=93 /ntot=227 /MaxReadThrough="3.45614" /MaxDrop="4.54398" /score="2.19825508" /energy="-10.3" /TU="U3205" /idTUdmin="U3205" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" downshifts 3794096 /Source="Nicolas_upshifts" /id="D2110" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="2.98662" /MaxDrop="3.29879" /score="2.19825508" /energy="-10.3" /TU="U3205" /idTUdmin="U3205" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" downshifts complement(3794150) /Source="Nicolas_upshifts" /id="D2111" /incds=0 /nref=1 /ntot=24 /MaxReadThrough="3.53364" /MaxDrop="2.25148" /score="10.1219981" /energy="-6.3" /TU="U3207" /idTUdmin="U3209" /TUdmin=2266 /isTUend="FALSE" /label="downshifts" CDS complement(3794155..3794943) /gene="ictI" /locus_tag="BSU_40630" /old_locus_tag="BSU40630" /function="16.8: Protect" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16321932, 22882546, 25835496" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16321932, 22882546, 25835496; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="inner spore coat protein" /protein_id="NP_391943.1" /db_xref="EnsemblGenomes-Gn:BSU40630" /db_xref="EnsemblGenomes-Tr:CAB16100" /db_xref="SubtiList:BG10022" /db_xref="UniProtKB/Swiss-Prot:P37495" /translation="MNVYDIRMAPYWFYEGRGLVQHPYVFRQPVSSRAIIVSTRGDVT GDGVIDEVFLTGNQMPGSPLWRNITLVIRDGRTHQEQRIQLQNNMGYNPSLFLGDMTG DKIEDVAVVMDTGGSGGAIYAYVFAYLNRQFRRIFNSDVLNDELKYSVRYQNQYKASV ISHQQNETYILDLTYKGREYLNEIYNSQGVLKMPIEGWVNPLSGLYPVDFDRDGVYEL LAYQRIAGRYNADSLGYVQTVLKWNGQRFMFNRQTVTIFGSDLS*" /label="ictI CDS" gene complement(3794155..3794943) /gene="ictI" /locus_tag="BSU_40630" /old_locus_tag="BSU40630" /label="ictI gene" promotor_-10 complement(3794967..3794985) /Source="Nicolas_upshift_promotors" /id="U3207" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1128 /SigmaFactorBS="gataattcatatggtacggatttaattggtgtgtaagataTG TCTTtgatgtgccattcctGCATATAATGATTCATTCAgctgattagggaaggtgaca c" /listShort="yybI, S1566" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3794986) /Source="Nicolas_upshifts" /id="U3207" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1128 /SigmaFactorBS="gataattcatatggtacggatttaattggtgtgtaagataTG TCTTtgatgtgccattcctGCATATAATGATTCATTCAgctgattagggaaggtgaca c" /listShort="yybI, S1566" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3795001..3795006) /Source="Nicolas_upshift_promotors" /id="U3207" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1128 /SigmaFactorBS="gataattcatatggtacggatttaattggtgtgtaagataTG TCTTtgatgtgccattcctGCATATAATGATTCATTCAgctgattagggaaggtgaca c" /listShort="yybI, S1566" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3795011..3795400) /gene="yybH" /locus_tag="BSU_40640" /old_locus_tag="BSU40640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391944.1" /db_xref="EnsemblGenomes-Gn:BSU40640" /db_xref="EnsemblGenomes-Tr:CAB16101" /db_xref="InterPro:IPR009959" /db_xref="InterPro:IPR032710" /db_xref="PDB:2GXF" /db_xref="SubtiList:BG10023" /db_xref="UniProtKB/Swiss-Prot:P37496" /translation="MEQQLKDIISACDLAIQNEDFDTLMNYYSEDAVLVVKPGMIARG KEEIKKAFITIANYFNHHIVPTQGKMILLEAGDTVLVLSQTLLDSDKKDSEYAMERRA TYVFKKNAQGEWLCVIDNSYGTDLIGV*" /label="yybH CDS" gene complement(3795011..3795400) /gene="yybH" /locus_tag="BSU_40640" /old_locus_tag="BSU40640" /label="yybH gene" promotor_-35 3795469..3795472 /Source="Nicolas_upshift_promotors" /id="U3208" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.999000999001" /xcortree=2554 /SigmaFactorBS="tcgctagaccactgaaaccttgaaaacaaAATGaaaagtatc cttttTTCCTATATAATCAAATAGAtatatttaacaaagtacccaagtgaaggggtga a" /listShort="yybG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3795487..3795506 /Source="Nicolas_upshift_promotors" /id="U3208" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.999000999001" /xcortree=2554 /SigmaFactorBS="tcgctagaccactgaaaccttgaaaacaaAATGaaaagtatc cttttTTCCTATATAATCAAATAGAtatatttaacaaagtacccaagtgaaggggtga a" /listShort="yybG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3795500 /Source="Nicolas_upshifts" /id="U3208" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.999000999001" /xcortree=2554 /SigmaFactorBS="tcgctagaccactgaaaccttgaaaacaaAATGaaaagtatc cttttTTCCTATATAATCAAATAGAtatatttaacaaagtacccaagtgaaggggtga a" /listShort="yybG" /GFF_Attribute="listLong" /label="upshifts" CDS 3795546..3796385 /gene="yybG" /locus_tag="BSU_40650" /old_locus_tag="BSU40650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11709313, 12486061" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391945.1" /db_xref="EnsemblGenomes-Gn:BSU40650" /db_xref="EnsemblGenomes-Tr:CAB16102" /db_xref="InterPro:IPR001646" /db_xref="SubtiList:BG10024" /db_xref="UniProtKB/Swiss-Prot:P37497" /translation="MSAEVTLHDNIHYDLSADCQHCFGLCCVALPYAKSADFAFDKDG GTPCRNLQSNYQCSIHKDLREKGFRGCSAYECFGAGQKVSQITYEGKDWRNSPETANQ MFDVFPIMQQLHEMLWYLHEALSIDIAKPIHSELRTTFEKIERLTRLSKERLLTLQVD EHRAEVNEWLLKTSELVRAQARHPKLPKKVSRGSVLIGAKLKGLDLRGANLRGALLIA ADLRNADLRMTDFIGADMRDADLSGADLTGSIFLTQAQVNAANGDSNTKLPLSVRTPA HWK*" /label="yybG CDS" gene 3795546..3796385 /gene="yybG" /locus_tag="BSU_40650" /old_locus_tag="BSU40650" /label="yybG gene" downshifts 3796362 /Source="Nicolas_upshifts" /id="D2112" /incds=0 /nref=35 /ntot=188 /MaxReadThrough="1.19247" /MaxDrop="3.72166" /score="-0.156630814" /energy="-6.3" /TU="NA" /idTUdmin="U3208" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3796418..3797632) /gene="yybF" /locus_tag="BSU_40660" /old_locus_tag="BSU40660" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9811656, 11557812, 12486061, 15849754, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_391946.1" /db_xref="EnsemblGenomes-Gn:BSU40660" /db_xref="EnsemblGenomes-Tr:CAB16103" /db_xref="GOA:P37498" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10025" /db_xref="UniProtKB/Swiss-Prot:P37498" /translation="MTYIRKGTPVFRKITFAFFAAGFNTFAILYCVQPLMEEFTREFH VTPTAASLSLSVTTMLLAVSMLVFGSLSEVWGRKPIMGISMLAASVLCLASAFSPSFH TLLVLRTIQGVALAGLPSIAMAYLGEEIEPGSLGSAMGLYISGNAIGAVFGRIVSGLL SEYLNWHMAMGTIGVISLIASVIFFINLPPSRHFTPRKLKLGKLGMSLIGHLRDRKLF SLFLIGFLLLGSNVALFNYIVYVLLGPPYSLNKAFSSWIFIVMIVGIFSSSFIGRMVD RYGYPKILVMNIFIVIAGALFTINNMLAVKILGIALFTFGFFGGHSVASSWVGRRALH NKAQASSLYLFFYYAGSSVFGTIGGLFWSGFHWLGVVGMITFMLLVALWLSGYLARSV KMPDKRNEKGLN*" /label="yybF CDS" gene complement(3796418..3797632) /gene="yybF" /locus_tag="BSU_40660" /old_locus_tag="BSU40660" /label="yybF gene" downshifts complement(3796436) /Source="Nicolas_upshifts" /id="D2113" /incds=0 /nref=45 /ntot=169 /MaxReadThrough="1.92237" /MaxDrop="5.70619" /score="10.1219981" /energy="-6.3" /TU="NA" /idTUdmin="U3209" /TUdmin="-20" /isTUend="TRUE" /label="downshifts" S_feature complement(3797633..3797736) /Source="Nicolas_S_feature" /locus_tag="new_4180378_4180481_c" /HighExp="BI, B60, ferm, T0.30H, T-1.10H, T-0.40H, T-1.40H, T1.0H, nit, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.94819299999999995" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1568" promotor_-10 complement(3797729..3797748) /Source="Nicolas_upshift_promotors" /id="U3209" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.728271728271728" /psig="0.996003996003996" /xcortree=1589 /SigmaFactorBS="catataagcatgaaaaggatattttatatgCATTATACaaca tatatcaacGGTGCTAAGATAATAATATAaacagactcgaggatgtttgaattcgtaa g" /listShort="S1568, yybF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 3797737..3797744 /Source="Nicolas_upshift_promotors" /id="U3210" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.627372627372627" /psig="0.997002997002997" /xcortree=2542 /SigmaFactorBS="aaacatcctcgagtctgtttatattatTATCTTAGcaccgtt gatataTGTTGTATAATGCATATAAAatatccttttcatgcttatatgtaataaggag a" /listShort="yybE" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3797739) /Source="Nicolas_upshifts" /id="U3209" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.728271728271728" /psig="0.996003996003996" /xcortree=1589 /SigmaFactorBS="catataagcatgaaaaggatattttatatgCATTATACaaca tatatcaacGGTGCTAAGATAATAATATAaacagactcgaggatgtttgaattcgtaa g" /listShort="S1568, yybF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3797758..3797777 /Source="Nicolas_upshift_promotors" /id="U3210" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.627372627372627" /psig="0.997002997002997" /xcortree=2542 /SigmaFactorBS="aaacatcctcgagtctgtttatattatTATCTTAGcaccgtt gatataTGTTGTATAATGCATATAAAatatccttttcatgcttatatgtaataaggag a" /listShort="yybE" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3797762..3797769) /Source="Nicolas_upshift_promotors" /id="U3209" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.728271728271728" /psig="0.996003996003996" /xcortree=1589 /SigmaFactorBS="catataagcatgaaaaggatattttatatgCATTATACaaca tatatcaacGGTGCTAAGATAATAATATAaacagactcgaggatgtttgaattcgtaa g" /listShort="S1568, yybF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3797770 /Source="Nicolas_upshifts" /id="U3210" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.627372627372627" /psig="0.997002997002997" /xcortree=2542 /SigmaFactorBS="aaacatcctcgagtctgtttatattatTATCTTAGcaccgtt gatataTGTTGTATAATGCATATAAAatatccttttcatgcttatatgtaataaggag a" /listShort="yybE" /GFF_Attribute="listLong" /label="upshifts" CDS 3797819..3798697 /gene="yybE" /locus_tag="BSU_40670" /old_locus_tag="BSU40670" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12169591, 17526699, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (LysR family)" /protein_id="NP_391947.2" /db_xref="EnsemblGenomes-Gn:BSU40670" /db_xref="EnsemblGenomes-Tr:CAB16104" /db_xref="GOA:P37499" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10026" /db_xref="UniProtKB/Swiss-Prot:P37499" /translation="MEWEQLEYFQTLARMQHVTKAAKSLSITQPALSRSIARLENHLG VPLFDRQGRSISLNQYGHIFLRRVQAMMKEYTEGKEEIQALLKPDQGVVSLGFLHTLG TTLVPDLIGSFQQEYPNISFQLKQNHSYWLLERLKSGDLDLCLLASIKPENPIQWIKL WSEELFVFVPNDHPLASRESITLNEIAGERFILLKKGYALRMTVDELFEKANIQPNIM FEGEEATTAAGFVAAGLGISILPDLKGLDQSKITKIRVSWPECQRVIGIAWIKGRFLS PVAETFKQYVISHFSE*" /label="yybE CDS" gene 3797819..3798697 /gene="yybE" /locus_tag="BSU_40670" /old_locus_tag="BSU40670" /label="yybE gene" CDS 3798711..3799154 /gene="yybD" /locus_tag="BSU_40680" /old_locus_tag="BSU40680" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_391948.1" /db_xref="EnsemblGenomes-Gn:BSU40680" /db_xref="EnsemblGenomes-Tr:CAB16105" /db_xref="GOA:P37500" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG10027" /db_xref="UniProtKB/Swiss-Prot:P37500" /translation="MNVKKITSEQDLHTAFEIRKAVFVEEQGCPISDEFDEFDTLHGD CQHILAYHQNVPVGTARVRIVGHTGKLERICILKSYRKFGLGKVIVDALERIVKEQGI SAFKLHGQTQAAGFYEKLGYRTASEEFMLDGIPHVLMTKQDDSAL*" /label="yybD CDS" gene 3798711..3799154 /gene="yybD" /locus_tag="BSU_40680" /old_locus_tag="BSU40680" /label="yybD gene" CDS 3799237..3799716 /gene="yybC" /locus_tag="BSU_40690" /old_locus_tag="BSU40690" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 28032445; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_391949.1" /db_xref="EnsemblGenomes-Gn:BSU40690" /db_xref="EnsemblGenomes-Tr:CAB16106" /db_xref="SubtiList:BG10028" /db_xref="UniProtKB/Swiss-Prot:P37501" /translation="MPANKKEGLIFGVMMCFGMVCVMSIYNAIINRAIYDFSLMTVFE MVIGFMIALLLDLLLVGPLAKKIAFRMPFDKTKKIYVILAMSTCMVIGMVLCMSVFGL VTAVLANGLNGDSLFSAYLMIVLKNFILAYPLQLLIMGPLVRGVFMKFVKPKLTAAI* " /label="yybC CDS" gene 3799237..3799716 /gene="yybC" /locus_tag="BSU_40690" /old_locus_tag="BSU40690" /label="yybC gene" downshifts 3799706 /Source="Nicolas_upshifts" /id="D2114" /incds=0 /nref=13 /ntot=97 /MaxReadThrough="0.69144" /MaxDrop="3.55998" /score="-9.53342462" /energy="-10.9" /TU="NA" /idTUdmin="U3210" /TUdmin=1628 /isTUend="FALSE" /label="downshifts" CDS complement(3799891..3800553) /gene="yybB" /locus_tag="BSU_40700" /old_locus_tag="BSU40700" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_391950.1" /db_xref="EnsemblGenomes-Gn:BSU40700" /db_xref="EnsemblGenomes-Tr:CAB16107" /db_xref="GOA:P37502" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG10029" /db_xref="UniProtKB/Swiss-Prot:P37502" /translation="MNLRQLSEHVFQCEFELDVPLRIPVHTWFIKDGDDVYIVDTGIE RFADAQIRAALAIGNPKAILLTHGHSDHIGGASKWLERFDIPIFAHQKELKYINGEEP YPNKNEVENTGVAHIVQPLTEQTLAHLPLKYYLTPGHSPGHVVYYHKIDRTLLTGDLF ITSKEDLHPPIRRFSVDINENIDSGSIIDQIKPTLICSSHGEEILYNEELYKNYVVRY RD*" /label="yybB CDS" gene complement(3799891..3800553) /gene="yybB" /locus_tag="BSU_40700" /old_locus_tag="BSU40700" /label="yybB gene" CDS complement(3800700..3801152) /gene="yybA" /locus_tag="BSU_40710" /old_locus_tag="BSU40710" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 23504016; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (MarR family, polyamine export and degradation)" /protein_id="NP_391951.1" /db_xref="EnsemblGenomes-Gn:BSU40710" /db_xref="EnsemblGenomes-Tr:CAB16108" /db_xref="GOA:P37503" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10030" /db_xref="UniProtKB/Swiss-Prot:P37503" /translation="MNDILREIGMIARALDSISNIEFKDLDLTRGQYLYLVRIYENPG IIQEKLAEMIKVDRTTAARAIKKLEMQGFIQKLPDEQNKKIKKLFPTEKGKKVYPLLR REGEHSTEVALSGFTSEEKETISALLHRVRKNIERDWEYVKKGNKRDY*" /label="yybA CDS" gene complement(3800700..3801152) /gene="yybA" /locus_tag="BSU_40710" /old_locus_tag="BSU40710" /label="yybA gene" promotor_-35 3801176..3801183 /Source="Nicolas_upshift_promotors" /id="U3211" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.706293706293706" /psig="0.998001998001998" /xcortree=1783 /SigmaFactorBS="aaatatcattcattcctaaaacccctcacgtattttTGTTGC AAttacaacaaaaatgTTTTAACCTTACTATTATAAgaccacatgcgtgctgtacagt c" /listShort="S1569, yyaT, yyaS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3801198..3801217 /Source="Nicolas_upshift_promotors" /id="U3211" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.706293706293706" /psig="0.998001998001998" /xcortree=1783 /SigmaFactorBS="aaatatcattcattcctaaaacccctcacgtattttTGTTGC AAttacaacaaaaatgTTTTAACCTTACTATTATAAgaccacatgcgtgctgtacagt c" /listShort="S1569, yyaT, yyaS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3801200 /Source="Nicolas_upshifts" /id="U3211" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.706293706293706" /psig="0.998001998001998" /xcortree=1783 /SigmaFactorBS="aaatatcattcattcctaaaacccctcacgtattttTGTTGC AAttacaacaaaaatgTTTTAACCTTACTATTATAAgaccacatgcgtgctgtacagt c" /listShort="S1569, yyaT, yyaS" /GFF_Attribute="listLong" /label="upshifts" S_feature 3801202..3801271 /Source="Nicolas_S_feature" /locus_tag="new_4183947_4184016" /HighExp="G135, G180, H2O2, LoTm, G150, Salt, Diami, Paraq, LBGstat, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1569" promotor_-10 complement(3801205..3801224) /Source="Nicolas_upshift_promotors" /id="U3212" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.481518481518482" /psig="0.992007992007992" /xcortree=2273 /SigmaFactorBS="aatcaatccttttctgatattagTCTGGACTgtacagcacgc aTGTGGTCTTATAATAGTAAGgttaaaacatttttgttgtaattgcaacaaaaatacg t" /listShort="yybA, yybB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3801207) /Source="Nicolas_upshifts" /id="U3212" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.481518481518482" /psig="0.992007992007992" /xcortree=2273 /SigmaFactorBS="aatcaatccttttctgatattagTCTGGACTgtacagcacgc aTGTGGTCTTATAATAGTAAGgttaaaacatttttgttgtaattgcaacaaaaatacg t" /listShort="yybA, yybB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3801237..3801244) /Source="Nicolas_upshift_promotors" /id="U3212" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.481518481518482" /psig="0.992007992007992" /xcortree=2273 /SigmaFactorBS="aatcaatccttttctgatattagTCTGGACTgtacagcacgc aTGTGGTCTTATAATAGTAAGgttaaaacatttttgttgtaattgcaacaaaaatacg t" /listShort="yybA, yybB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3801272..3801718 /gene="yyaT" /locus_tag="BSU_40720" /old_locus_tag="BSU40720" /EC_number="2.3.1.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase (polyamine degradation)" /protein_id="NP_391952.1" /db_xref="EnsemblGenomes-Gn:BSU40720" /db_xref="EnsemblGenomes-Tr:CAB16109" /db_xref="GOA:P37504" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG10031" /db_xref="UniProtKB/Swiss-Prot:P37504" /translation="MNIKRITTEADLHEALKIRRGVFIEEQHVSEADEFDEFDTLQEQ CQHILVYHENQPVGTGRARIVGHTAKLERICILKPYRKYGLGKIIVSGLEEIMKEKGL TSYKLHGQTQAAGFYQKLGYQISSQEFMEDGIPHVLMTKEISRNIT*" /label="yyaT CDS" gene 3801272..3801718 /gene="yyaT" /locus_tag="BSU_40720" /old_locus_tag="BSU40720" /label="yyaT gene" CDS 3801715..3802320 /gene="yyaS" /locus_tag="BSU_40730" /old_locus_tag="BSU40730" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 23504016; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391953.1" /db_xref="EnsemblGenomes-Gn:BSU40730" /db_xref="EnsemblGenomes-Tr:CAB16110" /db_xref="SubtiList:BG10032" /db_xref="UniProtKB/Swiss-Prot:P37505" /translation="MKYMYYGIGILILSLGISLTIQSGLGTSPFDALLVGLSKKIGLT VGSWEVLISVILLICNAILTRKKPILLGLITAFITGIGIDLWLFVVKNTIYLNSLLSK LICFGIGLVLIGLGTAIYLQTKFASTPIDHLTLIIRDLSKRTILFSRTLVYALFLVLA IIFKGPIGIGTLLTVCLGGMLLHVFMPIVERHFLSKNRRGY*" /label="yyaS CDS" gene 3801715..3802320 /gene="yyaS" /locus_tag="BSU_40730" /old_locus_tag="BSU40730" /label="yyaS gene" CDS complement(3802415..3802936) /gene="yyaR" /locus_tag="BSU_40740" /old_locus_tag="BSU40740" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16579456, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyl-transferase" /protein_id="NP_391954.1" /db_xref="EnsemblGenomes-Gn:BSU40740" /db_xref="EnsemblGenomes-Tr:CAB16111" /db_xref="GOA:P37506" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR008125" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG10033" /db_xref="UniProtKB/Swiss-Prot:P37506" /translation="MIMKMTHLNMKDFNKPNEPFVVFGRMIPAFENGVWTYTEERFSK PYFKQYEDDDMDVSYVEEEGKAAFLYYLENNCIGRIKIRSNWNGYALIEDIAVAKDYR KKGVGTALLHKAIEWAKENHFCGLMLETQDINISACHFYAKHHFIIGAVDTMLYSNFP TANEIAIFWYYKF*" /label="yyaR CDS" gene complement(3802415..3802936) /gene="yyaR" /locus_tag="BSU_40740" /old_locus_tag="BSU40740" /label="yyaR gene" S_feature complement(3802937..3803764) /Source="Nicolas_S_feature" /locus_tag="new_4185682_4186509_c" /HighExp="T0.30H, Lbstat, H2O2, LPhT, T1.0H, dia15, Diami, T1.30H, dia5, M9-stat" /AntisenseName="yyaQ" /AntisenseCor="0.51412050904654805" /AntisenseRegPval="-18.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1570" promotor_-35 3802985..3802992 /Source="Nicolas_upshift_promotors" /id="U3213" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.667332667332667" /psig="0.955044955044955" /xcortree=607 /SigmaFactorBS="cgccaatcgagataatatttagtaaactcgtttcgatacTAT TCAACaacagcttccaaaaGTGTACTCTTTAAGAGAACAgcattagataaggcatcca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3803006 /Source="Nicolas_upshifts" /id="U3213" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.667332667332667" /psig="0.955044955044955" /xcortree=607 /SigmaFactorBS="cgccaatcgagataatatttagtaaactcgtttcgatacTAT TCAACaacagcttccaaaaGTGTACTCTTTAAGAGAACAgcattagataaggcatcca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3803007..3803026 /Source="Nicolas_upshift_promotors" /id="U3213" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.667332667332667" /psig="0.955044955044955" /xcortree=607 /SigmaFactorBS="cgccaatcgagataatatttagtaaactcgtttcgatacTAT TCAACaacagcttccaaaaGTGTACTCTTTAAGAGAACAgcattagataaggcatcca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3803072..3803346 /Source="Nicolas_S_feature" /locus_tag="new_4185817_4186091" /HighExp="LBGstat, G135, BC, G180, Sw, M9-stat, Diami, T0.30H, H2O2, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.13713" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1571" upshifts 3803072 /Source="Nicolas_upshifts" /id="U3214" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig="0.999000999001" /xcortree=2754 /SigmaFactorBS="ctctttaagagaacagcattagataaggcatccattacctta tatatttcactatcttaatgaGGTATTtcaacagaggctTGTGGTACAGTAAAAAGGA A" /listShort="S1571, yyaQ, S1572, yyaP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3803075..3803080 /Source="Nicolas_upshift_promotors" /id="U3214" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig="0.999000999001" /xcortree=2754 /SigmaFactorBS="ctctttaagagaacagcattagataaggcatccattacctta tatatttcactatcttaatgaGGTATTtcaacagaggctTGTGGTACAGTAAAAAGGA A" /listShort="S1571, yyaQ, S1572, yyaP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3803093..3803112 /Source="Nicolas_upshift_promotors" /id="U3214" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig="0.999000999001" /xcortree=2754 /SigmaFactorBS="ctctttaagagaacagcattagataaggcatccattacctta tatatttcactatcttaatgaGGTATTtcaacagaggctTGTGGTACAGTAAAAAGGA A" /listShort="S1571, yyaQ, S1572, yyaP" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3803347..3803703 /gene="yyaQ" /locus_tag="BSU_40750" /old_locus_tag="BSU40750" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391955.1" /db_xref="EnsemblGenomes-Gn:BSU40750" /db_xref="EnsemblGenomes-Tr:CAB16112" /db_xref="InterPro:IPR007351" /db_xref="SubtiList:BG10034" /db_xref="UniProtKB/Swiss-Prot:P37507" /translation="MLTREDIFKHVKEKYGTSPDYPWEKYPNYASLRHTSNKKWYGLI MNVLPEKLGLDGHGEIDILNLKCPPEISDRLRNGENILPGYHMDKEHWISIVLERTDP EGEIYNLIEQSFHLTK*" /label="yyaQ CDS" gene 3803347..3803703 /gene="yyaQ" /locus_tag="BSU_40750" /old_locus_tag="BSU40750" /label="yyaQ gene" S_feature 3803704..3803862 /Source="Nicolas_S_feature" /locus_tag="new_4186449_4186607" /HighExp="Sw, BC, G135, H2O2, LBGstat, G180, LPhT, T0.30H, Diami, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1572" promotor_-10 complement(3803746..3803765) /Source="Nicolas_upshift_promotors" /id="U3215" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.942057942057942" /psig="0.997002997002997" /xcortree=621 /SigmaFactorBS="cttctcccactctcgcaccagatgaactaagttgcgtTTGTG GACagagtgaagaacagTATCCTAAAATGAAAGTGCCcactactcttcgcagcttgat t" /listShort="S1570, yyaR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3803764) /Source="Nicolas_upshifts" /id="U3215" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.942057942057942" /psig="0.997002997002997" /xcortree=621 /SigmaFactorBS="cttctcccactctcgcaccagatgaactaagttgcgtTTGTG GACagagtgaagaacagTATCCTAAAATGAAAGTGCCcactactcttcgcagcttgat t" /listShort="S1570, yyaR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3803780..3803787) /Source="Nicolas_upshift_promotors" /id="U3215" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.942057942057942" /psig="0.997002997002997" /xcortree=621 /SigmaFactorBS="cttctcccactctcgcaccagatgaactaagttgcgtTTGTG GACagagtgaagaacagTATCCTAAAATGAAAGTGCCcactactcttcgcagcttgat t" /listShort="S1570, yyaR" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3803863..3804429 /gene="yyaP" /locus_tag="BSU_40760" /old_locus_tag="BSU40760" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391956.1" /db_xref="EnsemblGenomes-Gn:BSU40760" /db_xref="EnsemblGenomes-Tr:CAB16113" /db_xref="GOA:P37508" /db_xref="InterPro:IPR002734" /db_xref="InterPro:IPR024072" /db_xref="PDB:2GD9" /db_xref="SubtiList:BG10035" /db_xref="UniProtKB/Swiss-Prot:P37508" /translation="MTNNLKQRRIILDLAVTLDGFIEGKNGEVDWCIMDPDMGFTDFL NQIDTILYGRKSFDLWGQYIPKNEDPDTEKELWKLVHSKKKYVFSRTQNEIDNQAIFI NDNILEEVNKLKKNPGKDIWLYGGASLITTFINLGLVDEFRLSIHPVVLGEGKPLFID VKQRINLKMVNTRTFSSGVVQIVYHWNG*" /label="yyaP CDS" gene 3803863..3804429 /gene="yyaP" /locus_tag="BSU_40760" /old_locus_tag="BSU40760" /label="yyaP gene" CDS complement(3804936..3806312) /gene="tetB" /locus_tag="BSU_40770" /old_locus_tag="BSU40770" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7961647, 14636065, 15849754, 16850406, 17015648, 25954268" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7961647, 14636065, 15849754, 16850406, 17015648, 25954268; Product type t : transporter" /codon_start=1 /transl_table=11 /product="multifunctional tetracycline-metal/H+ antiporterand Na+(K+)/H+ antiporter" /protein_id="NP_391957.1" /db_xref="EnsemblGenomes-Gn:BSU40770" /db_xref="EnsemblGenomes-Tr:CAB16114" /db_xref="GOA:P23054" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10036" /db_xref="UniProtKB/Swiss-Prot:P23054" /translation="MNTSYSQSTLRHNQVLIWLCVLSFFSVLNEMVLNVSLPDIANEF NKLPASANWVNTAFMLTFSIGTALYGKLSDQLGIKNLLLFGIMVNGLGSIIGFVGHSF FPILILARFIQGIGAAAFPALVMVVVARYIPKENRGKAFGLIGSLVAMGEGVGPAIGG MVAHYIHWSYLLLIPTATIITVPFLIKLLKKEERIRGHIDMAGIILMSAGIVFFMLFT TSYRFSFLIISILAFFIFVQHIRKAQDPFVDPELGKNVFFVIGTLCGGLIFGTVAGFV SMVPYMMKDVHHLSTAAIGSGIIFPGTMSVIIFGYIGGLLVDRKGSLYVLTIGSALLS SGFLIAAFFIDAAPWIMTIIVIFVFGGLSFTKTVISTVVSSSLKEKEAGAGMSLLNFT SFLSEGTGIAIVGGLLSIGFLDHRLLPIDVDHSTYLYSNMLILFAGIIVICWLVILNV YKRSRRHG*" /label="tetB CDS" gene complement(3804936..3806312) /gene="tetB" /locus_tag="BSU_40770" /old_locus_tag="BSU40770" /label="tetB gene" CDS complement(3806346..3806408) /gene="tetL" /locus_tag="BSU_40780" /old_locus_tag="BSU40780" /function="16.3: Control" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:14636065, 17015648" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14636065, 17015648; Product type t: transporter" /codon_start=1 /transl_table=11 /product="tetracycline resistance leader peptide" /protein_id="NP_391958.1" /db_xref="EnsemblGenomes-Gn:BSU40780" /db_xref="EnsemblGenomes-Tr:CAB16115" /db_xref="GOA:P23053" /db_xref="InterPro:IPR012618" /db_xref="SubtiList:BG11051" /db_xref="UniProtKB/Swiss-Prot:P23053" /translation="MKCNKMNRVQLKEGSVSMTL*" /label="tetL CDS" gene complement(3806346..3806408) /gene="tetL" /locus_tag="BSU_40780" /old_locus_tag="BSU40780" /label="tetL gene" promotor_-10 complement(3806429..3806448) /Source="Nicolas_upshift_promotors" /id="U3216" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.635364635364635" /psig="0.998001998001998" /xcortree=2216 /SigmaFactorBS="ttgtttcgcaatctggtcaaatttttataaaaaaagtaaaAG TTTAATccttagtctataTATAATAAGATCATATCAATcaaatgtagggggagttatt a" /listShort="tetL, tetB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3806448) /Source="Nicolas_upshifts" /id="U3216" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.635364635364635" /psig="0.998001998001998" /xcortree=2216 /SigmaFactorBS="ttgtttcgcaatctggtcaaatttttataaaaaaagtaaaAG TTTAATccttagtctataTATAATAAGATCATATCAATcaaatgtagggggagttatt a" /listShort="tetL, tetB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3806461..3806468) /Source="Nicolas_upshift_promotors" /id="U3216" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.635364635364635" /psig="0.998001998001998" /xcortree=2216 /SigmaFactorBS="ttgtttcgcaatctggtcaaatttttataaaaaaagtaaaAG TTTAATccttagtctataTATAATAAGATCATATCAATcaaatgtagggggagttatt a" /listShort="tetL, tetB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3806596..3806602 /Source="Nicolas_upshift_promotors" /id="U3217" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.612387612387612" /psig="0.998001998001998" /xcortree=618 /SigmaFactorBS="tttcacatcacaattatcgataagcagtcagtTATTGTAttt gtttaggataacTGTGGTAACCTGAATATAACcaacttaggaagaaggtgatcccatg c" /listShort="yyaO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3806618..3806637 /Source="Nicolas_upshift_promotors" /id="U3217" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.612387612387612" /psig="0.998001998001998" /xcortree=618 /SigmaFactorBS="tttcacatcacaattatcgataagcagtcagtTATTGTAttt gtttaggataacTGTGGTAACCTGAATATAACcaacttaggaagaaggtgatcccatg c" /listShort="yyaO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3806624 /Source="Nicolas_upshifts" /id="U3217" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.612387612387612" /psig="0.998001998001998" /xcortree=618 /SigmaFactorBS="tttcacatcacaattatcgataagcagtcagtTATTGTAttt gtttaggataacTGTGGTAACCTGAATATAACcaacttaggaagaaggtgatcccatg c" /listShort="yyaO" /GFF_Attribute="listLong" /label="upshifts" CDS 3806661..3806900 /gene="yyaO" /locus_tag="BSU_40790" /old_locus_tag="BSU40790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391959.1" /db_xref="EnsemblGenomes-Gn:BSU40790" /db_xref="EnsemblGenomes-Tr:CAB16116" /db_xref="InterPro:IPR004879" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG10037" /db_xref="UniProtKB/Swiss-Prot:P37509" /translation="MPNKSKPNRLIAEKSPYLLQHAHNPVDWFPWGEEAFAKAKRENK PVLVSIGYSTTCHWWPGIIKSCGTPLKDNRSHFKR*" /label="yyaO CDS" gene 3806661..3806900 /gene="yyaO" /locus_tag="BSU_40790" /old_locus_tag="BSU40790" /label="yyaO gene" downshifts 3806909 /Source="Nicolas_upshifts" /id="D2115" /incds=0 /nref=7 /ntot=103 /MaxReadThrough="1.03879" /MaxDrop="3.89186" /score="10.758481" /energy="-8.2" /TU="NA" /idTUdmin="U3217" /TUdmin=9 /isTUend="TRUE" /label="downshifts" promotor_-35 3806993..3807000 /Source="Nicolas_upshift_promotors" /id="U3218" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.994005994005994" /xcortree=1993 /SigmaFactorBS="gcggtagcaggtttttttattTGCTTGACttagagttaactc taAATTGTAAACTAACTTTAATtaaatgagagggatgatgttgttgtattccattagt a" /listShort="yyaN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3807016..3807035 /Source="Nicolas_upshift_promotors" /id="U3218" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.994005994005994" /xcortree=1993 /SigmaFactorBS="gcggtagcaggtttttttattTGCTTGACttagagttaactc taAATTGTAAACTAACTTTAATtaaatgagagggatgatgttgttgtattccattagt a" /listShort="yyaN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3807032 /Source="Nicolas_upshifts" /id="U3218" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.994005994005994" /xcortree=1993 /SigmaFactorBS="gcggtagcaggtttttttattTGCTTGACttagagttaactc taAATTGTAAACTAACTTTAATtaaatgagagggatgatgttgttgtattccattagt a" /listShort="yyaN" /GFF_Attribute="listLong" /label="upshifts" CDS 3807051..3807467 /gene="yyaN" /locus_tag="BSU_40800" /old_locus_tag="BSU40800" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11948146, 14663075; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MerR family)" /protein_id="NP_391960.1" /db_xref="EnsemblGenomes-Gn:BSU40800" /db_xref="EnsemblGenomes-Tr:CAB16117" /db_xref="GOA:P37510" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="SubtiList:BG10038" /db_xref="UniProtKB/Swiss-Prot:P37510" /translation="MLLYSISKAAEKTSISSYTLRYYEKIGLLPPPKRKNSGRRFYTE TDIQFMLFLKSLKETGMSLEDINEFVKDGCILEKINSDVKSAQLSPSINKRIEILTKH LEKMEIKKRELEEVISTTKGKLDTYYSILKEEVENK*" /label="yyaN CDS" gene 3807051..3807467 /gene="yyaN" /locus_tag="BSU_40800" /old_locus_tag="BSU40800" /label="yyaN gene" CDS 3807464..3808381 /gene="yyaM" /locus_tag="BSU_40810" /old_locus_tag="BSU40810" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_391961.1" /db_xref="EnsemblGenomes-Gn:BSU40810" /db_xref="EnsemblGenomes-Tr:CAB16118" /db_xref="GOA:P37511" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG10039" /db_xref="UniProtKB/Swiss-Prot:P37511" /translation="MKHLNIYIMLLGFSIFTGATFNLAKYTVGYFSPSSSAAWRFGLA AAVMLIILIFTEGIKKSQLRKNAVSYIVLGIIGIFGFNALFFVGLKYTSPVNGALIMG LNPLLTAILARIILKDNMTKKQVLGIFFAFIGVLLVITQGSIETIKTLSISGGDLIIF TGNVCWALYGVLGRRFVKDGTPLSTTTYTMVIGAVSLIVVSLFTSKPVSLSNIPIGVW GAIAFMAFFTSVLGYLWWNQGIKEIGASKTSLFFNLVPVVTMIISFAVGTPIKVFQVI GAVLVILGVLTASGVIRIPKYNTKEQSAI*" /label="yyaM CDS" gene 3807464..3808381 /gene="yyaM" /locus_tag="BSU_40810" /old_locus_tag="BSU40810" /label="yyaM gene" misc_feature 3808408..3808427 /Source="Nicolas_upshift_promotors" /id="U3219" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.841158841158841" /psig="0.984015984015984" /xcortree=1462 /SigmaFactorBS="actaaagaacagtcagctatataaagaaatagggagtatttt tgagaaaaTGTGTTAAGTTAAATATACActaattataggaagaaggtgatcccatgcc a" /listShort="yyaL" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3808418 /Source="Nicolas_upshifts" /id="U3219" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.841158841158841" /psig="0.984015984015984" /xcortree=1462 /SigmaFactorBS="actaaagaacagtcagctatataaagaaatagggagtatttt tgagaaaaTGTGTTAAGTTAAATATACActaattataggaagaaggtgatcccatgcc a" /listShort="yyaL" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3808422..3808441) /Source="Nicolas_upshift_promotors" /id="U3220" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.616383616383616" /psig="0.978021978021978" /xcortree=3109 /SigmaFactorBS="attgattaatctattgggtttactttTGTTTGGCatgggatc accttCTTCCTATAATTAGTGTATAtttaacttaacacattttctcaaaaatactccc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3808428) /Source="Nicolas_upshifts" /id="U3220" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.616383616383616" /psig="0.978021978021978" /xcortree=3109 /SigmaFactorBS="attgattaatctattgggtttactttTGTTTGGCatgggatc accttCTTCCTATAATTAGTGTATAtttaacttaacacattttctcaaaaatactccc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 3808453..3810522 /gene="yyaL" /locus_tag="BSU_40820" /old_locus_tag="BSU40820" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391962.1" /db_xref="EnsemblGenomes-Gn:BSU40820" /db_xref="EnsemblGenomes-Tr:CAB16119" /db_xref="GOA:P37512" /db_xref="InterPro:IPR004879" /db_xref="InterPro:IPR008928" /db_xref="InterPro:IPR024705" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG10040" /db_xref="UniProtKB/Swiss-Prot:P37512" /translation="MPNKSKPNRLINEKSPYLLQHAHNPVDWFPWGEEAFEKAKRENK PVLVSIGYSTCHWCHVMAHESFEDEEIARLLNERFVAIKVDREERPDVDSVYMRICQL MTGQGGWPLNVFITPDQKPFYAGTYFPKTSKFNRPGFVDVLEHLSETFANDREHVEDI AENAAKHLQTKTAAKTGEGLSESAIHRTFQQLASGFDTIYGGFGQAPKFPMPHMLMYL LRYDHNTGQENALYNVTKTLDSMANGGIYDHIGYGFARYSTDDEWLVPHFEKMLYDNA LLLTAYTEAYQVTQNSRYKEICEQIITFIQREMTHEDGSFFSALDADTEGEEGKYYVW SKEEILKTLGDDLGTLYCQVYDITEEGNFEGKNIPNLIHTKREQIKEDAGLTEKELSL KLEDARQQLLKTREERTYPHVDDKVLTSWNALMIAGLAKAAKVYQEPKYLSLAKDAIT FIENKLIIDGRVMVRYRDGEVKNKGFIDDYAFLLWAYLDLYEASFDLSYLQKAKKLTD DMISLFWDEEHGGFYFTGHDAEALIVREKEVYDGAVPSGNSVAAVQLLRLGQVTGDLS LIEKAETMFSVFKPDIEAYPSGHAFFMQSVLRHLMPKKEIVIFGSADDPARKQIIAEL QKAFKPNDSILVAEQPEQCKDIAPFAADYRIIDGKTTVYICENFACQQPTTNIEEAIH TLISSRD*" /label="yyaL CDS" gene 3808453..3810522 /gene="yyaL" /locus_tag="BSU_40820" /old_locus_tag="BSU40820" /label="yyaL gene" promotor_-35 complement(3808455..3808462) /Source="Nicolas_upshift_promotors" /id="U3220" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.616383616383616" /psig="0.978021978021978" /xcortree=3109 /SigmaFactorBS="attgattaatctattgggtttactttTGTTTGGCatgggatc accttCTTCCTATAATTAGTGTATAtttaacttaacacattttctcaaaaatactccc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3810486 /Source="Nicolas_upshifts" /id="D2116" /incds=0 /nref=221 /ntot=260 /MaxReadThrough="1.24617" /MaxDrop="5.71843" /score="11.6894527" /energy="-16.6" /TU="NA" /idTUdmin="U3219" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3810519..3811418) /gene="yyaK" /locus_tag="BSU_40830" /old_locus_tag="BSU40830" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11343912, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protease" /protein_id="NP_391963.1" /db_xref="EnsemblGenomes-Gn:BSU40830" /db_xref="EnsemblGenomes-Tr:CAB16120" /db_xref="GOA:P37513" /db_xref="InterPro:IPR003675" /db_xref="SubtiList:BG10041" /db_xref="UniProtKB/Swiss-Prot:P37513" /translation="MNSFIRPIEGNNTLWRYFFAFLVMVGLYVLGNIAYLFAILFTVI VNPNITFDLDEAVLSDPLVDLYLSHVIYLFAIPGVWLAVRFILKRPFRTVITPNSKMN WRRISFGFIAYFLLMIAVQLIDFVIHPDSYSMQEFNASRFIWLLAAALILVPIQTSAE ELFFRGFLLQAFGRLTKNPLFLTLIVGGLFGVLHFANPEMNNGAVWAGIEYLTFGFVW TYYTIKTGSIEISLGAHAANNMFLCMFITEKNSVYGGIPSLFTVTRGNPMWEAFFTIA VNLVFAGIALWYHKKSKSKQQGS*" /label="yyaK CDS" gene complement(3810519..3811418) /gene="yyaK" /locus_tag="BSU_40830" /old_locus_tag="BSU40830" /label="yyaK gene" downshifts complement(3810562) /Source="Nicolas_upshifts" /id="D2117" /incds=0 /nref=65 /ntot=246 /MaxReadThrough="2.6155" /MaxDrop="3.91098" /score="23.2445146" /energy="-14.7" /TU="NA" /idTUdmin="U3221" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3811447..3811466) /Source="Nicolas_upshift_promotors" /id="U3221" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.839160839160839" /psig="0.98001998001998" /xcortree=2400 /SigmaFactorBS="ttatattttaattttgcttaaaagatttccaaaacAGTAGAT TcatagaccaatttaTGCAAATATATAGTAATATTctcattgaaaggaagagacatag a" /listShort="yyaK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3811463) /Source="Nicolas_upshifts" /id="U3221" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.839160839160839" /psig="0.98001998001998" /xcortree=2400 /SigmaFactorBS="ttatattttaattttgcttaaaagatttccaaaacAGTAGAT TcatagaccaatttaTGCAAATATATAGTAATATTctcattgaaaggaagagacatag a" /listShort="yyaK" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3811465..3812696) /Source="Nicolas_S_feature" /locus_tag="new_4194210_4195441_c" /HighExp="S6, S8, S7, S5, B36, BT, S4, B60, S3, Diami" /AntisenseName="yyaJ" /AntisenseCor="-0.24400480530035801" /AntisenseRegPval="-4.3" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1573" promotor_-35 complement(3811481..3811488) /Source="Nicolas_upshift_promotors" /id="U3221" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.839160839160839" /psig="0.98001998001998" /xcortree=2400 /SigmaFactorBS="ttatattttaattttgcttaaaagatttccaaaacAGTAGAT TcatagaccaatttaTGCAAATATATAGTAATATTctcattgaaaggaagagacatag a" /listShort="yyaK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3811559..3811566 /Source="Nicolas_upshift_promotors" /id="U3222" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.725274725274725" /psig="0.978021978021978" /xcortree=3158 /SigmaFactorBS="tgtgaatttagttcttccatctagtgatttgaaCTCTGTTGc caatgaaccaagATACTTATAATAGTCCCAAGaggggaattttcagtcttttctacta c" /listShort="yyaJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3811580..3811599 /Source="Nicolas_upshift_promotors" /id="U3222" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.725274725274725" /psig="0.978021978021978" /xcortree=3158 /SigmaFactorBS="tgtgaatttagttcttccatctagtgatttgaaCTCTGTTGc caatgaaccaagATACTTATAATAGTCCCAAGaggggaattttcagtcttttctacta c" /listShort="yyaJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3811586 /Source="Nicolas_upshifts" /id="U3222" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.725274725274725" /psig="0.978021978021978" /xcortree=3158 /SigmaFactorBS="tgtgaatttagttcttccatctagtgatttgaaCTCTGTTGc caatgaaccaagATACTTATAATAGTCCCAAGaggggaattttcagtcttttctacta c" /listShort="yyaJ" /GFF_Attribute="listLong" /label="upshifts" CDS 3811644..3812999 /gene="yyaJ" /locus_tag="BSU_40840" /old_locus_tag="BSU40840" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 9529885, 19087206, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_391964.2" /db_xref="EnsemblGenomes-Gn:BSU40840" /db_xref="EnsemblGenomes-Tr:CAB16121" /db_xref="GOA:P37514" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10042" /db_xref="UniProtKB/Swiss-Prot:P37514" /translation="MNTIFKQKNTHPFSNAANRLDRLPISRVHFQVLTALGIVYFFDL ADLFTLSNVAPALIEHWGIPLSTIANVTAASFLGMFLGASLGGRLSDRIGRKKALNLF VFVFSIASLCNAAAWDIPSLMTFRFLTGFGVAAAMVITNSYLAEFFPSSVRGKYISFC AMIGLIGVPITNIVSAFVIPLGSWGWRLVFVWGAVGLIYFFFIHRLEESPRWHENRGE YAKADAILTRIEEQVEKEKGPLPAASQPKVSETVKQNAGYAGLLKGRNLKITIVLSAV WIFETFGFYGFASWVPSLLKSNGVTMENTLWYNVLHSVGAPLGALLGSMISERFQRKW ILAASAFLTAIAGLLYGMTFIPIMIIVFGFIVNITERVFTSNLYAYTSEPYPTEYRSS GSGLAYGLGRFSNIFGSLLVGFIAVQLGYISVFLFIGGCWLACSLLLIFFGPNTNAKQ I*" /label="yyaJ CDS" gene 3811644..3812999 /gene="yyaJ" /locus_tag="BSU_40840" /old_locus_tag="BSU40840" /label="yyaJ gene" promotor_-10 complement(3812682..3812701) /Source="Nicolas_upshift_promotors" /id="U3223" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1260 /SigmaFactorBS="aggtaaagacccgttctgtgatattcacgataaaaccaaata CAATGATCATgatgggaataaaaGTCATACCATATAAGAGCCCggcgatggccgtcag a" /listShort="S1573, yyaK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3812706) /Source="Nicolas_upshifts" /id="U3223" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1260 /SigmaFactorBS="aggtaaagacccgttctgtgatattcacgataaaaccaaata CAATGATCATgatgggaataaaaGTCATACCATATAAGAGCCCggcgatggccgtcag a" /listShort="S1573, yyaK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3812715..3812724) /Source="Nicolas_upshift_promotors" /id="U3223" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1260 /SigmaFactorBS="aggtaaagacccgttctgtgatattcacgataaaaccaaata CAATGATCATgatgggaataaaaGTCATACCATATAAGAGCCCggcgatggccgtcag a" /listShort="S1573, yyaK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3813033..3813587) /gene="maa" /locus_tag="BSU_40850" /old_locus_tag="BSU40850" /EC_number="2.3.1.79" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12731863, 12793527, 19087206, 22226636, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="maltose O-acetyltransferase" /protein_id="NP_391965.1" /db_xref="EnsemblGenomes-Gn:BSU40850" /db_xref="EnsemblGenomes-Tr:CAB16122" /db_xref="GOA:P37515" /db_xref="InterPro:IPR001451" /db_xref="InterPro:IPR011004" /db_xref="InterPro:IPR018357" /db_xref="InterPro:IPR024688" /db_xref="SubtiList:BG10043" /db_xref="UniProtKB/Swiss-Prot:P37515" /translation="MLRTEKEKMAAGELYNSEDQQLLLERKHARQLIRQYNETPEDDA VRTKLLKELLGSVGDQVTILPTFRCDYGYHIHIGDHTFVNFDCVILDVCEVRIGCHCL IAPGVHIYTAGHPLDPIERKSGKEFGKPVTIGDQVWIGGRAVINPGVTIGDNAVIASG SVVTKDVPANTVVGGNPARILKQL*" /label="maa CDS" gene complement(3813033..3813587) /gene="maa" /locus_tag="BSU_40850" /old_locus_tag="BSU40850" /label="maa gene" CDS complement(3813605..3813985) /gene="yyaH" /locus_tag="BSU_40860" /old_locus_tag="BSU40860" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19087206; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative C-S lyase" /protein_id="NP_391966.1" /db_xref="EnsemblGenomes-Gn:BSU40860" /db_xref="EnsemblGenomes-Tr:CAB16123" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG10044" /db_xref="UniProtKB/Swiss-Prot:P37516" /translation="MQIEHTAVWVNDLERMKSFYESYFNGEANDLYHNEKKDFKSYFI TFDSGARLEIMKKGNVTDPPSQTMTGWAHIAFSVGSREKVDELTDRLKADGFAVVNGP RTTGDGYYESVIEDDEGNLIEITI*" /label="yyaH CDS" gene complement(3813605..3813985) /gene="yyaH" /locus_tag="BSU_40860" /old_locus_tag="BSU40860" /label="yyaH gene" CDS complement(3814041..3814976) /gene="ccpB" /locus_tag="BSU_40870" /old_locus_tag="BSU40870" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9457849, 9642180, 16267306" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9457849, 9642180, 16267306; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of carbon supply (LacIfamily)" /protein_id="NP_391967.1" /db_xref="EnsemblGenomes-Gn:BSU40870" /db_xref="EnsemblGenomes-Tr:CAB16124" /db_xref="GOA:P37517" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR001761" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG10045" /db_xref="UniProtKB/Swiss-Prot:P37517" /translation="MANIKEIARLANVSVSTVSRVLNHHPYVSEEKRKLVHQVMKELD YTPNRTAIDLIRGKTHTVGVILPYSDHPCFDKIVNGITKAAFQHEYATTLLPTNYNPD IEIKYLELLRTKKIDGLIITSRANHWDSILAYQEYGPVIACEDTGDIDVPCAFNDRKT AYAESFRYLKSRGHENIAFTCVREADRSPSTADKAAAYKAVCGRLEDRHMLSGCNDMN DGELAAEHFYMSGRVPTAIYANSDEVAAGIHLFAKKNNWDVEIIGEGNTSISRVLGFP SLDLNLEQLGIAAFSLFLQDEPADIKIQHKFKKKA*" /label="ccpB CDS" gene complement(3814041..3814976) /gene="ccpB" /locus_tag="BSU_40870" /old_locus_tag="BSU40870" /label="ccpB gene" promotor_-35 3814966..3814975 /Source="Nicolas_upshift_promotors" /id="U3224" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=1390 /SigmaFactorBS="gatacatttgccagtcttgcgatctcttttATATTTGCCAtc tctttctccttTTCATATAAAAAAAGCAGTAagtgtaaaatccttactgctatctcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3814989..3815008 /Source="Nicolas_upshift_promotors" /id="U3224" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=1390 /SigmaFactorBS="gatacatttgccagtcttgcgatctcttttATATTTGCCAtc tctttctccttTTCATATAAAAAAAGCAGTAagtgtaaaatccttactgctatctcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3814996 /Source="Nicolas_upshifts" /id="U3224" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=1390 /SigmaFactorBS="gatacatttgccagtcttgcgatctcttttATATTTGCCAtc tctttctccttTTCATATAAAAAAAGCAGTAagtgtaaaatccttactgctatctcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3815020..3815039) /Source="Nicolas_upshift_promotors" /id="U3225" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5004995004995" /psig="0.998001998001998" /xcortree=2935 /SigmaFactorBS="atatcagcggacgtcatgggttccgaccattgtccTGTTGAA CttatcatcaataTATGATGAGATAGCAGTAAGgattttacacttactgcttttttta t" /listShort="ccpB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3815034) /Source="Nicolas_upshifts" /id="U3225" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5004995004995" /psig="0.998001998001998" /xcortree=2935 /SigmaFactorBS="atatcagcggacgtcatgggttccgaccattgtccTGTTGAA CttatcatcaataTATGATGAGATAGCAGTAAGgattttacacttactgcttttttta t" /listShort="ccpB" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3815035..3815793) /gene="exoA" /locus_tag="BSU_40880" /old_locus_tag="BSU40880" /EC_number="3.1.11.2" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10540738, 16237020, 18203828, 21441501, 24244006, 24914186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10540738, 16237020, 18203828, 21441501, 24244006, 24914186; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="apurinic/apyrimidinic endonuclease" /protein_id="NP_391968.1" /db_xref="EnsemblGenomes-Gn:BSU40880" /db_xref="EnsemblGenomes-Tr:CAB16125" /db_xref="GOA:P37454" /db_xref="InterPro:IPR004808" /db_xref="InterPro:IPR005135" /db_xref="InterPro:IPR020847" /db_xref="InterPro:IPR020848" /db_xref="InterPro:IPR036691" /db_xref="PDB:5CFE" /db_xref="SubtiList:BG10046" /db_xref="UniProtKB/Swiss-Prot:P37454" /translation="MKLISWNVNGLRAVMRKMDFLSYLKEEDADIICLQETKIQDGQV DLQPEDYHVYWNYAVKKGYSGTAVFSKQEPLQVIYGIGVEEHDQEGRVITLEFENVFV MTVYTPNSRRGLERIDYRMQWEEALLSYILELDQKKPVILCGDLNVAHQEIDLKNPKA NRNNAGFSDQEREAFTRFLEAGFVDSFRHVYPDLEGAYSWWSYRAGARDRNIGWRIDY FVVSESLKEQIEDASISADVMGSDHCPVELIINI*" /label="exoA CDS" gene complement(3815035..3815793) /gene="exoA" /locus_tag="BSU_40880" /old_locus_tag="BSU40880" /label="exoA gene" promotor_-35 complement(3815052..3815059) /Source="Nicolas_upshift_promotors" /id="U3225" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5004995004995" /psig="0.998001998001998" /xcortree=2935 /SigmaFactorBS="atatcagcggacgtcatgggttccgaccattgtccTGTTGAA CttatcatcaataTATGATGAGATAGCAGTAAGgattttacacttactgcttttttta t" /listShort="ccpB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3815326..3815829 /Source="Nicolas_S_feature" /locus_tag="new_4198071_4198574" /HighExp="C30, S8, S7, S6, BT, S5, M/G, Glucon, C90, T1.0H" /AntisenseName="exoAA" /AntisenseCor="-0.177921457862244" /AntisenseRegPval="-2.5" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1574" downshifts 3815788 /Source="Nicolas_upshifts" /id="D2118" /incds=0 /nref=2 /ntot=12 /MaxReadThrough="2.65789" /MaxDrop="4.11352" /score="16.4680636" /energy="-6.8" /TU="NA" /idTUdmin="U3224" /TUdmin=528 /isTUend="FALSE" /label="downshifts" CDS complement(3815858..3816097) /gene="rpsR" /locus_tag="BSU_40890" /old_locus_tag="BSU40890" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14762004, 22720735, 24310371" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14762004, 22720735, 24310371; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S18" /protein_id="NP_391969.2" /db_xref="EnsemblGenomes-Gn:BSU40890" /db_xref="EnsemblGenomes-Tr:CAB16126" /db_xref="GOA:P21475" /db_xref="InterPro:IPR001648" /db_xref="InterPro:IPR018275" /db_xref="InterPro:IPR036870" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10047" /db_xref="UniProtKB/Swiss-Prot:P21475" /translation="MAGGRRGGRAKRRKVCYFTSNGITHIDYKDVDLLKKFVSERGKI LPRRVTGTNAKYQRKLTAAIKRARQMALLPYVSGE*" /label="rpsR CDS" gene complement(3815858..3816097) /gene="rpsR" /locus_tag="BSU_40890" /old_locus_tag="BSU40890" /label="rpsR gene" downshifts complement(3815864) /Source="Nicolas_upshifts" /id="D2119" /incds=0 /nref=217 /ntot=268 /MaxReadThrough="4.97781" /MaxDrop="7.46952" /score="21.7622917" /energy="-15.3" /TU="U3226,U3227" /idTUdmin="U3229" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(3815932) /Source="Nicolas_upshifts" /id="D2120" /incds=1 /nref=13 /ntot=142 /MaxReadThrough="8.89363" /MaxDrop="3.9797" /score="21.7622917" /energy="-15.3" /TU="U3226,U3227,U3229" /idTUdmin="U3229" /TUdmin="-68" /isTUend="FALSE" /label="downshifts" CDS complement(3816141..3816659) /gene="ssbA" /locus_tag="BSU_40900" /old_locus_tag="BSU40900" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12682299, 14762004, 16549871, 10072765, 25138221, 26001966, 28575448" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14762004, 16549871, 10072765, 25138221, 26001966, 28575448; Product type f: factor" /codon_start=1 /transl_table=11 /product="single-strand DNA-binding protein" /protein_id="NP_391970.1" /db_xref="EnsemblGenomes-Gn:BSU40900" /db_xref="EnsemblGenomes-Tr:CAB16127" /db_xref="GOA:P37455" /db_xref="InterPro:IPR000424" /db_xref="InterPro:IPR011344" /db_xref="InterPro:IPR012340" /db_xref="SubtiList:BG10048" /db_xref="UniProtKB/Swiss-Prot:P37455" /translation="MLNRVVLVGRLTKDPELRYTPNGAAVATFTLAVNRTFTNQSGER EADFINCVTWRRQAENVANFLKKGSLAGVDGRLQTRNYENQQGQRVFVTEVQAESVQF LEPKNGGGSGSGGYNEGNSGGGQYFGGGQNDNPFGGNQNNQRRNQGNSFNDDPFANDG KPIDISDDDLPF*" /label="ssbA CDS" gene complement(3816141..3816659) /gene="ssbA" /locus_tag="BSU_40900" /old_locus_tag="BSU40900" /label="ssbA gene" CDS complement(3816700..3816987) /gene="rpsF" /locus_tag="BSU_40910" /old_locus_tag="BSU40910" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14762004, 19653700, 26447183" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14762004, 19653700, 26447183; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S6 (BS9)" /protein_id="NP_391971.1" /db_xref="EnsemblGenomes-Gn:BSU40910" /db_xref="EnsemblGenomes-Tr:CAB16128" /db_xref="GOA:P21468" /db_xref="InterPro:IPR000529" /db_xref="InterPro:IPR014717" /db_xref="InterPro:IPR020814" /db_xref="InterPro:IPR020815" /db_xref="InterPro:IPR035980" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10049" /db_xref="UniProtKB/Swiss-Prot:P21468" /translation="MRKYEVMYIIRPNIDEESKKAVIERFNNVLTSNGAEITGTKDWG KRRLAYEINDFRDGFYQIVNVQSDAAAVQEFDRLAKISDDIIRHIVVKEEE*" /label="rpsF CDS" gene complement(3816700..3816987) /gene="rpsF" /locus_tag="BSU_40910" /old_locus_tag="BSU40910" /label="rpsF gene" S_feature complement(3816988..3817054) /Source="Nicolas_S_feature" /locus_tag="new_4199733_4199799_c" /HighExp="MG t5, LPhT, GM 90, SMM, T-5.40H, GM-0.2, MG 150, GM 45, Gly, M9-exp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 0.993, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1575" promotor_-10 complement(3817053..3817072) /Source="Nicolas_upshift_promotors" /id="U3226" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.443556443556444" /psig=1 /xcortree=2653 /SigmaFactorBS="tccgatttaatgtataggatgcaGTTGTAaagggacaagagc TTTGGTATAATATAAAATTGtgagtaatagaattattgctccttgcccattatgggcc g" /listShort="S1575, rpsF, ssbA, rpsR, exoAA, ccpB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3817054) /Source="Nicolas_upshifts" /id="U3226" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.443556443556444" /psig=1 /xcortree=2653 /SigmaFactorBS="tccgatttaatgtataggatgcaGTTGTAaagggacaagagc TTTGGTATAATATAAAATTGtgagtaatagaattattgctccttgcccattatgggcc g" /listShort="S1575, rpsF, ssbA, rpsR, exoAA, ccpB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3817086..3817091) /Source="Nicolas_upshift_promotors" /id="U3226" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.443556443556444" /psig=1 /xcortree=2653 /SigmaFactorBS="tccgatttaatgtataggatgcaGTTGTAaagggacaagagc TTTGGTATAATATAAAATTGtgagtaatagaattattgctccttgcccattatgggcc g" /listShort="S1575, rpsF, ssbA, rpsR, exoAA, ccpB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3817098..3818198) /gene="engD" /locus_tag="BSU_40920" /old_locus_tag="BSU40920" /function="16.6: Maintain" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12837776, 16014871, 18713637, 21527254, 22995830, 26018081, 26160547, 26912459; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="potassium-dependent informational ATPase interacting with 70S ribosome; ROS stress regulator" /protein_id="NP_391972.1" /db_xref="EnsemblGenomes-Gn:BSU40920" /db_xref="EnsemblGenomes-Tr:CAB16129" /db_xref="GOA:P37518" /db_xref="InterPro:IPR004396" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR012676" /db_xref="InterPro:IPR013029" /db_xref="InterPro:IPR023192" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031167" /db_xref="SubtiList:BG10050" /db_xref="UniProtKB/Swiss-Prot:P37518" /translation="MALTAGIVGLPNVGKSTLFNAITQAGAESANYPFCTIDPNVGIV EVPDDRLQKLTELVNPKKTVPTAFEFTDIAGIVKGASKGEGLGNKFLSHIRQVDAICH VVRAFSDDNITHVSGKVDPIDDIETINLELILADMETVEKRITRVSKLAKQKDKDAVF EFEILSKLKEAFESEKPARSVEFTEEQQKLVKQLHLLTSKPILYVANVSEDEVADPSG NENVAKIREYAAGENAEVIVVCAKIESEIAELEGEEKQMFLEELGIQESGLDQLIKAS YSLLGLATYFTAGEQEVRAWTFKKGMKAPECAGIIHSDFERGFIRAETVAYEDLLAGG GMAGAKEAGKVRLEGKEYVVQDGDVIHFRFNV*" /label="engD CDS" gene complement(3817098..3818198) /gene="engD" /locus_tag="BSU_40920" /old_locus_tag="BSU40920" /label="engD gene" promotor_-10 complement(3818246..3818265) /Source="Nicolas_upshift_promotors" /id="U3227" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.65034965034965" /psig="0.993006993006993" /xcortree=2193 /SigmaFactorBS="aagggattggcaagctgaaaatgcttttttgtcaGCTTGTCT tttccagtgaacctCCTTATAATTGCTCTAGGTTcaaaatacgttcatacaatgacgg t" /listShort="engD, S1575, rpsF, ssbA, rpsR, exoAA" /listLong="ccpB" /label="promotor_-10" upshifts complement(3818261) /Source="Nicolas_upshifts" /id="U3227" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.65034965034965" /psig="0.993006993006993" /xcortree=2193 /SigmaFactorBS="aagggattggcaagctgaaaatgcttttttgtcaGCTTGTCT tttccagtgaacctCCTTATAATTGCTCTAGGTTcaaaatacgttcatacaatgacgg t" /listShort="engD, S1575, rpsF, ssbA, rpsR, exoAA" /listLong="ccpB" /label="upshifts" promotor_-35 complement(3818280..3818287) /Source="Nicolas_upshift_promotors" /id="U3227" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.65034965034965" /psig="0.993006993006993" /xcortree=2193 /SigmaFactorBS="aagggattggcaagctgaaaatgcttttttgtcaGCTTGTCT tttccagtgaacctCCTTATAATTGCTCTAGGTTcaaaatacgttcatacaatgacgg t" /listShort="engD, S1575, rpsF, ssbA, rpsR, exoAA" /listLong="ccpB" /label="promotor_-35" CDS complement(3818325..3820328) /gene="yyaE" /locus_tag="BSU_40930" /old_locus_tag="BSU40930" /EC_number="1.-.-.-" /function="3.2: Degradation" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17114254, 20817769; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase (molybdoenzyme)" /protein_id="NP_391973.1" /db_xref="EnsemblGenomes-Gn:BSU40930" /db_xref="EnsemblGenomes-Tr:CAB16130" /db_xref="GOA:P37519" /db_xref="InterPro:IPR006656" /db_xref="InterPro:IPR006657" /db_xref="InterPro:IPR006963" /db_xref="InterPro:IPR009010" /db_xref="SubtiList:BG10051" /db_xref="UniProtKB/Swiss-Prot:P37519" /translation="MSKVHQSACPLNCWDSCGFLVTVDDGKVTKVDGDPNHPITEGKI CGRGRMLETKTNSPDRLRYPMKKQNGEFVRISWEQALDEIADKLREIKETSETTAVLH SHDYANNGLLKALDQRFFNGYGGVTEIVGSICWGSGIEAQSWDFGRSYGHGPLDIYNS KHVVVWGRNVSRTNMHLYHHLQQVKKKGATITVIDPIFNPTAKLADRYISVKPGMDGW LAAAVLKVLIEMGRTDETFISEHSVGFDDVKELLKTVSLEEFIVKTETSMEELEYLAG LYADGPVSTFMGLGMQRYKNGGGTIRWIDALVAASGNVGIKGGGANFGNVQIGESFAK TKLTLPELKTTSRSFSMMTQAEEVLTAADPAIEMIIVTCGNPLTQVPNTNKVRQAFEK VPMTVAIDSIMTDTAELCDYVLPTATVFEEEDIYYSSMYHHYVQYGKKLVEPQGEAKS DSWIWSELAKRLGFGELFEYSTQEFLEMGLSSLEAEDVTLERLKEKGHLPLPVKQVPW DDYQFLTPSGKFEFTSSLAEQKGFSGSLQLNVPEESVFHNEELAGKYPYTLLSIHPQR SNHSQHVPFIEKLQHVQVDISPDIAAGQDLQDGDEVVIFNDRGSMKGKVKVMKQAHAK TINIDEGMWAAFGGSVNALTNDTNSDNGMGSTLFDCLVGLKKA*" /label="yyaE CDS" gene complement(3818325..3820328) /gene="yyaE" /locus_tag="BSU_40930" /old_locus_tag="BSU40930" /label="yyaE gene" CDS complement(3820379..3820585) /gene="yyzM" /locus_tag="BSU_40939" /old_locus_tag="BSU40939" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 21348639, 22333191, 27435445; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative nucleic acid binding protein" /protein_id="YP_003097803.1" /db_xref="EnsemblGenomes-Gn:BSU40939" /db_xref="EnsemblGenomes-Tr:CAX52723" /db_xref="InterPro:IPR009296" /db_xref="UniProtKB/Swiss-Prot:C0H3V8" /translation="MADKDFGLNDIVEMKKPHPCGANSWKIIRMGMDIRIKCEGCSHS VMIPRREFERKLKKVLVKHEEPTS*" /label="yyzM CDS" gene complement(3820379..3820585) /gene="yyzM" /locus_tag="BSU_40939" /old_locus_tag="BSU40939" /label="yyzM gene" promotor_-10 complement(3820547..3820566) /Source="Nicolas_upshift_promotors" /id="U3228" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.83016983016983" /xcortree=1588 /SigmaFactorBS="ttttttgtacaatagatacagcagtttaggaaaagaggtgaa gggTCTTGGCggataaagactttgGCCTGAATGATATCGTAGAAatgaaaaaaccgca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3820572) /Source="Nicolas_upshifts" /id="U3228" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.83016983016983" /xcortree=1588 /SigmaFactorBS="ttttttgtacaatagatacagcagtttaggaaaagaggtgaa gggTCTTGGCggataaagactttgGCCTGAATGATATCGTAGAAatgaaaaaaccgca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3820581..3820587) /Source="Nicolas_upshift_promotors" /id="U3228" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.83016983016983" /xcortree=1588 /SigmaFactorBS="ttttttgtacaatagatacagcagtttaggaaaagaggtgaa gggTCTTGGCggataaagactttgGCCTGAATGATATCGTAGAAatgaaaaaaccgca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3820611..3820630) /Source="Nicolas_upshift_promotors" /id="U3229" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.646353646353646" /psig="0.999000999001" /xcortree=1832 /SigmaFactorBS="ataagaggatgtatttcttttcgggtatcttGATTGctctta tgatcagtttTTTTGTACAATAGATACAGCagtttaggaaaagaggtgaagggtcttg g" /listShort="yyzM, yyaE, engD, S1575, rpsF, ssbA, rpsR" /listLong="exoAA" /label="promotor_-10" upshifts complement(3820622) /Source="Nicolas_upshifts" /id="U3229" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.646353646353646" /psig="0.999000999001" /xcortree=1832 /SigmaFactorBS="ataagaggatgtatttcttttcgggtatcttGATTGctctta tgatcagtttTTTTGTACAATAGATACAGCagtttaggaaaagaggtgaagggtcttg g" /listShort="yyzM, yyaE, engD, S1575, rpsF, ssbA, rpsR" /listLong="exoAA" /label="upshifts" promotor_-35 complement(3820647..3820651) /Source="Nicolas_upshift_promotors" /id="U3229" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.646353646353646" /psig="0.999000999001" /xcortree=1832 /SigmaFactorBS="ataagaggatgtatttcttttcgggtatcttGATTGctctta tgatcagtttTTTTGTACAATAGATACAGCagtttaggaaaagaggtgaagggtcttg g" /listShort="yyzM, yyaE, engD, S1575, rpsF, ssbA, rpsR" /listLong="exoAA" /label="promotor_-35" CDS complement(3820679..3821695) /gene="yyaD" /locus_tag="BSU_40940" /old_locus_tag="BSU40940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16847258, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_391974.1" /db_xref="EnsemblGenomes-Gn:BSU40940" /db_xref="EnsemblGenomes-Tr:CAB16131" /db_xref="SubtiList:BG10052" /db_xref="UniProtKB/Swiss-Prot:P37520" /translation="MLWRAGMKWMLLILGSLIGAGYASGQEIWQFFGAESGLAIVLFT IMFIFSSYIVMKISFKVQSTHFLPVLEHLMGPWLAKIYDVLIIFYLFSTTMVMIAGGG VTLQMYKLPFWWGITLICIVTVCLFLWDVKGILSINSILIPVLVAGLLYALISFQSTH HHTWTIDLSQQYNWPASITFTSLNILSVVAILSSVGKEMKGLGEAKIASVASGLIFGV ISFVYNETLVELAGSLSQFEIPLFAVLEGAPYFLFLCMTAVLCLAIYTTTVAGLLGLS SRLMAFIHMPRWMIVLILLVLMVPFTSFGFSDLIAFLYPIYGMLNLYLLVCLLLYPIL SKWK*" /label="yyaD CDS" gene complement(3820679..3821695) /gene="yyaD" /locus_tag="BSU_40940" /old_locus_tag="BSU40940" /label="yyaD gene" promotor_-10 complement(3821728..3821746) /Source="Nicolas_upshift_promotors" /id="U3230" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=972 /SigmaFactorBS="tttcagcttgtgttcaaatgtctatgaaaatatGGCATGttt gctttcctttatTTATATAGTAACAATAACGggaacaagctgaactttgtctatgagg t" /listShort="yyaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3821740) /Source="Nicolas_upshifts" /id="U3230" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=972 /SigmaFactorBS="tttcagcttgtgttcaaatgtctatgaaaatatGGCATGttt gctttcctttatTTATATAGTAACAATAACGggaacaagctgaactttgtctatgagg t" /listShort="yyaD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3821762..3821767) /Source="Nicolas_upshift_promotors" /id="U3230" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=972 /SigmaFactorBS="tttcagcttgtgttcaaatgtctatgaaaatatGGCATGttt gctttcctttatTTATATAGTAACAATAACGggaacaagctgaactttgtctatgagg t" /listShort="yyaD" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3821871) /Source="Nicolas_upshifts" /id="D2121" /incds=0 /nref=32 /ntot=184 /MaxReadThrough="1.8976" /MaxDrop="3.72136" /score="9.09987016" /energy="-7.4" /TU="NA" /idTUdmin="U3230" /TUdmin="-397" /isTUend="FALSE" /label="downshifts" promotor_-35 3822055..3822060 /Source="Nicolas_upshift_promotors" /id="U3231" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1073 /SigmaFactorBS="tcatgccctctacttttttaaaatctctggtgccatacacaa AGCATAaaaaatcatactgctGGATATACTGTAAACAACCttacataactacacacac c" /listShort="S1576, yyaC" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3822073..3822154 /Source="Nicolas_S_feature" /locus_tag="new_4204818_4204899" /HighExp="S4, S5, S3, S6, LoTm, S7, T5.0H, BT, M9-stat, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1576" upshifts 3822073 /Source="Nicolas_upshifts" /id="U3231" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1073 /SigmaFactorBS="tcatgccctctacttttttaaaatctctggtgccatacacaa AGCATAaaaaatcatactgctGGATATACTGTAAACAACCttacataactacacacac c" /listShort="S1576, yyaC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3822076..3822094 /Source="Nicolas_upshift_promotors" /id="U3231" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1073 /SigmaFactorBS="tcatgccctctacttttttaaaatctctggtgccatacacaa AGCATAaaaaatcatactgctGGATATACTGTAAACAACCttacataactacacacac c" /listShort="S1576, yyaC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3822155..3822772 /gene="sprC" /locus_tag="BSU_40950" /old_locus_tag="BSU40950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 26362088; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="spore-specific protease" /protein_id="NP_391975.1" /db_xref="EnsemblGenomes-Gn:BSU40950" /db_xref="EnsemblGenomes-Tr:CAB16132" /db_xref="InterPro:IPR009665" /db_xref="InterPro:IPR023430" /db_xref="SubtiList:BG10053" /db_xref="UniProtKB/Swiss-Prot:P37521" /translation="MNRKGGLFSSQERVKQYVSHTDAAAAKQIQTILSSSLRKAAGKP IVVVCIGTDRSTGDSLGPLVGMKLKQMQLTRFHVYGTLSDPVHAVNMKDKINDIHKLH KNPFVIAVDACLGRVKSVGSFQIGDGPLKPGAGVQKDLPEVGDLHINGIVNVSGFMEY FVLQNTRLNLVMNMANVLAEGLSLTDRTEWRQERLNPLQRLTGRI*" /label="sprC CDS" gene 3822155..3822772 /gene="sprC" /locus_tag="BSU_40950" /old_locus_tag="BSU40950" /label="sprC gene" promotor_-35 3822743..3822751 /Source="Nicolas_upshift_promotors" /id="U3232" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.440559440559441" /psig="0.440559440559441" /xcortree=291 /SigmaFactorBS="gaggcaagaacgccttaacCCGTTGCAAaggctcactgggcG CATATAAAATAAAAACCAtcttcgtttgaaagatggttttttcatttatgattctcgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3822762 /Source="Nicolas_upshifts" /id="D2122" /incds=0 /nref=11 /ntot=30 /MaxReadThrough="2.64888" /MaxDrop="3.74502" /score="0.352922387" /energy="-6.6" /TU="NA" /idTUdmin="U3231" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 3822765..3822783 /Source="Nicolas_upshift_promotors" /id="U3232" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.440559440559441" /psig="0.440559440559441" /xcortree=291 /SigmaFactorBS="gaggcaagaacgccttaacCCGTTGCAAaggctcactgggcG CATATAAAATAAAAACCAtcttcgtttgaaagatggttttttcatttatgattctcgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3822784 /Source="Nicolas_upshifts" /id="U3232" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.440559440559441" /psig="0.440559440559441" /xcortree=291 /SigmaFactorBS="gaggcaagaacgccttaacCCGTTGCAAaggctcactgggcG CATATAAAATAAAAACCAtcttcgtttgaaagatggttttttcatttatgattctcgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3822811..3823659) /gene="parB" /locus_tag="BSU_40960" /old_locus_tag="BSU40960" /function="16.9: Replicate" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11532141, 12950914, 15659156, 15774898, 15998739, 16677298, 21235642, 28407103" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11532141, 12950914, 15659156, 15774898, 15998739, 16677298, 21235642, 28407103; Product type f: factor" /codon_start=1 /transl_table=11 /product="site-specific DNA-binding protein" /protein_id="NP_391976.1" /db_xref="EnsemblGenomes-Gn:BSU40960" /db_xref="EnsemblGenomes-Tr:CAB16133" /db_xref="GOA:P26497" /db_xref="InterPro:IPR003115" /db_xref="InterPro:IPR004437" /db_xref="InterPro:IPR036086" /db_xref="SubtiList:BG10054" /db_xref="UniProtKB/Swiss-Prot:P26497" /translation="MAKGLGKGINALFNQVDLSEETVEEIKIADLRPNPYQPRKHFDD EALAELKESVLQHGILQPLIVRKSLKGYDIVAGERRFRAAKLAGLDTVPAIVRELSEA LMREIALLENLQREDLSPLEEAQAYDSLLKHLDLTQEQLAKRLGKSRPHIANHLRLLT LPENIQQLIAEGTLSMGHGRTLLGLKNKNKLEPLVQKVIAEQLNVRQLEQLIQQLNQN VPRETKKKEPVKDAVLKERESYLQNYFGTTVNIKRQKKKGKIEIEFFSNEDLDRILEL LSERES*" /label="parB CDS" gene complement(3822811..3823659) /gene="parB" /locus_tag="BSU_40960" /old_locus_tag="BSU40960" /label="parB gene" downshifts complement(3822831) /Source="Nicolas_upshifts" /id="D2123" /incds=0 /nref=208 /ntot=265 /MaxReadThrough="3.01094" /MaxDrop="5.3801" /score="9.82080496" /energy="-7.9" /TU="U3233" /idTUdmin="U3233" /TUdmin="-257" /isTUend="FALSE" /label="downshifts" CDS complement(3823652..3824413) /gene="parA" /locus_tag="BSU_40970" /old_locus_tag="BSU40970" /function="16.13: Shape" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:11532141, 12950914, 15659156, 15774898, 15998739, 16677298, 18077387, 28166228" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11532141, 12950914, 15659156, 15774898, 15998739, 16677298, 18077387, 28166228; Product type f: factor" /codon_start=1 /transl_table=11 /product="chromosome partitioning protein; transcriptionalregulator" /protein_id="NP_391977.1" /db_xref="EnsemblGenomes-Gn:BSU40970" /db_xref="EnsemblGenomes-Tr:CAB16134" /db_xref="GOA:P37522" /db_xref="InterPro:IPR025669" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10055" /db_xref="UniProtKB/Swiss-Prot:P37522" /translation="MGKIIAITNQKGGVGKTTTSVNLGACLAYIGKRVLLVDIDPQGN ATSGLGIEKADVEQCVYDILVDDADVIDIIKATTVENLDVIPATIQLAGAEIELVPTI SREVRLKRALEAVKQNYDYIIIDCPPSLGLLTINALTASDSVVIPVQCEYYALEGLSQ LLNTVRLVQKHLNTDLMIEGVLLTMLDARTNLGIQVIEEVKKYFRDKVYKTVIPRNVR LSEAPSHGKPIILYDPRSRGAEVYLDLAKEVAANG*" /label="parA CDS" gene complement(3823652..3824413) /gene="parA" /locus_tag="BSU_40970" /old_locus_tag="BSU40970" /label="parA gene" misc_feature complement(3824447..3824466) /Source="Nicolas_upshift_promotors" /id="U3233" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=2325 /SigmaFactorBS="attatttcccttctgattcggaacaaaatgatgaaaaaaatg aaacgctttaatcttttTTTGATAGAATAGAAGCAAGatagtacatgttcatgtgaaa g" /listShort="parA, parB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3824465) /Source="Nicolas_upshifts" /id="U3233" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=2325 /SigmaFactorBS="attatttcccttctgattcggaacaaaatgatgaaaaaaatg aaacgctttaatcttttTTTGATAGAATAGAAGCAAGatagtacatgttcatgtgaaa g" /listShort="parA, parB" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3824557) /Source="Nicolas_upshifts" /id="U3234" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=1771 /SigmaFactorBS="tttttttctttaagaaattccttttttAAGTCAAAAaaacat agaaattGCAGAATTTataagagaaagcataaagcgtgcttgaattttcaattatttc c" /GFF_Attribute="listShort" /listLong="parA, parB" /label="upshifts" promotor_-10 complement(3824560..3824568) /Source="Nicolas_upshift_promotors" /id="U3234" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=1771 /SigmaFactorBS="tttttttctttaagaaattccttttttAAGTCAAAAaaacat agaaattGCAGAATTTataagagaaagcataaagcgtgcttgaattttcaattatttc c" /GFF_Attribute="listShort" /listLong="parA, parB" /label="promotor_-10" promotor_-35 complement(3824582..3824590) /Source="Nicolas_upshift_promotors" /id="U3234" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=1771 /SigmaFactorBS="tttttttctttaagaaattccttttttAAGTCAAAAaaacat agaaattGCAGAATTTataagagaaagcataaagcgtgcttgaattttcaattatttc c" /GFF_Attribute="listShort" /listLong="parA, parB" /label="promotor_-35" promotor_-35 3824594..3824602 /Source="Nicolas_upshift_promotors" /id="U3235" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=500 /SigmaFactorBS="tttctcttataaattctgcaatttctatgtttttttgactta aaAAAGGAATTtcttaaagaaaAAAAGAAGAAGTCACAGTAcagaacgtggaaacagg a" /listShort="yyaB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3824610 /Source="Nicolas_upshifts" /id="U3235" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=500 /SigmaFactorBS="tttctcttataaattctgcaatttctatgtttttttgactta aaAAAGGAATTtcttaaagaaaAAAAGAAGAAGTCACAGTAcagaacgtggaaacagg a" /listShort="yyaB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3824614..3824632 /Source="Nicolas_upshift_promotors" /id="U3235" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=500 /SigmaFactorBS="tttctcttataaattctgcaatttctatgtttttttgactta aaAAAGGAATTtcttaaagaaaAAAAGAAGAAGTCACAGTAcagaacgtggaaacagg a" /listShort="yyaB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3824661..3825101 /gene="yyaB" /locus_tag="BSU_40980" /old_locus_tag="BSU40980" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 25651892; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative antibiotic immunity protein" /protein_id="NP_391978.2" /db_xref="EnsemblGenomes-Gn:BSU40980" /db_xref="EnsemblGenomes-Tr:CAB16135" /db_xref="GOA:P37523" /db_xref="InterPro:IPR009589" /db_xref="SubtiList:BG10056" /db_xref="UniProtKB/Swiss-Prot:P37523" /translation="MVYQTKRDVPVTLMIVFLILLIQADAIVPFVLGNMRVSGWIIFI LLTLLNGLIIWSFIDLKYVLKEHHLIIKAGLIKHQIPYENIDKVVQKKKLWSGFRLIG SRHAITIYYQGGWGHAVISPQKSEEFIHKLKEKNSNIIIFTKSK*" /label="yyaB CDS" gene 3824661..3825101 /gene="yyaB" /locus_tag="BSU_40980" /old_locus_tag="BSU40980" /label="yyaB gene" downshifts 3825050 /Source="Nicolas_upshifts" /id="D2124" /incds=0 /nref=3 /ntot=144 /MaxReadThrough="2.25356" /MaxDrop="3.41185" /score="-0.6683508" /energy="-14.5" /TU="NA" /idTUdmin="U3235" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3825152..3826003) /gene="nocA" /locus_tag="BSU_40990" /old_locus_tag="BSU40990" /function="16.13: Shape" /function="16.8: Protect" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:11807071, 15210112, 16549676, 25568309, 28500529" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11807071, 15210112, 16549676, 25568309, 28500529; Product type f: factor" /codon_start=1 /transl_table=11 /product="DNA-binding protein Spo0J-like" /protein_id="NP_391979.1" /db_xref="EnsemblGenomes-Gn:BSU40990" /db_xref="EnsemblGenomes-Tr:CAB16136" /db_xref="GOA:P37524" /db_xref="InterPro:IPR003115" /db_xref="InterPro:IPR004437" /db_xref="InterPro:IPR023705" /db_xref="InterPro:IPR036086" /db_xref="SubtiList:BG10057" /db_xref="UniProtKB/Swiss-Prot:P37524" /translation="MKHSFSRFFGLGEKEQEPEIAEHDTNKEEILEIPVNAIVPNRFQ PRTIFSDEKIKELAMTIHTHGIIQPIVVRHTEEEGQYELIAGERRWRAVQSLEWEKIP AIIKDFSDTETASVALIENLQREELSSIEEAHAYARLLELHDLTQEALAQRLGKGQST IANKLRLLKLPQPVQEAIMEKKITERHARALIPLKQPELQVTLLTEIIEKSLNVKQTE DRVVKMLEQGQRKPKPRRKAFSRDTRIAMNTIRQSLSMVEDSGVKLNTEEEEFEEYIQ LTIRIPK*" /label="nocA CDS" gene complement(3825152..3826003) /gene="nocA" /locus_tag="BSU_40990" /old_locus_tag="BSU40990" /label="nocA gene" downshifts complement(3825171) /Source="Nicolas_upshifts" /id="D2125" /incds=0 /nref=245 /ntot=265 /MaxReadThrough="2.30868" /MaxDrop="6.68899" /score="29.5496038" /energy="-14.5" /TU="NA" /idTUdmin="U3236" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" S_feature complement(3826004..3826124) /Source="Nicolas_S_feature" /locus_tag="new_4208749_4208869_c" /HighExp="LBGstat, G135, G180, H2O2, dia15, G150, Paraq, T0.30H, Oxctl, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1577" CDS complement(3826125..3826844) /gene="rsmG" /locus_tag="BSU_41000" /old_locus_tag="BSU41000" /EC_number="2.1.1.170" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12001236, 17238915, 17573471, 19622680, 24509311" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12001236, 17238915, 17573471, 19622680, 24509311; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="7-methylguanosine methyltransferase (16S rRNA, nucleotide G527)" /protein_id="NP_391980.1" /db_xref="EnsemblGenomes-Gn:BSU41000" /db_xref="EnsemblGenomes-Tr:CAB16137" /db_xref="GOA:P25813" /db_xref="InterPro:IPR003682" /db_xref="InterPro:IPR029063" /db_xref="PDB:1XDZ" /db_xref="SubtiList:BG10058" /db_xref="UniProtKB/Swiss-Prot:P25813" /translation="MNIEEFTSGLAEKGISLSPRQLEQFELYYDMLVEWNEKINLTSI TEKKEVYLKHFYDSITAAFYVDFNQVNTICDVGAGAGFPSLPIKICFPHLHVTIVDSL NKRITFLEKLSEALQLENTTFCHDRAETFGQRKDVRESYDIVTARAVARLSVLSELCL PLVKKNGLFVALKAASAEEELNAGKKAITTLGGELENIHSFKLPIEESDRNIMVIRKI KNTPKKYPRKPGTPNKSPIEG*" /label="rsmG CDS" gene complement(3826125..3826844) /gene="rsmG" /locus_tag="BSU_41000" /old_locus_tag="BSU41000" /label="rsmG gene" CDS complement(3826858..3828744) /gene="trmF" /locus_tag="BSU_41010" /old_locus_tag="BSU41010" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11914360, 14993678, 17062623, 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA uridine 5-carboxymethylaminomethyl modification enzyme" /protein_id="NP_391981.1" /db_xref="EnsemblGenomes-Gn:BSU41010" /db_xref="EnsemblGenomes-Tr:CAB16138" /db_xref="GOA:P25812" /db_xref="InterPro:IPR002218" /db_xref="InterPro:IPR004416" /db_xref="InterPro:IPR020595" /db_xref="InterPro:IPR026904" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG10059" /db_xref="UniProtKB/Swiss-Prot:P25812" /translation="MGYEAGQYDVIVIGAGHAGVEAALASARQGAKTLVLTINLDMVA FMPCNPSVGGPAKGIVVREIDALGGEMGRNIDKTHIQMRMLNTGKGPAVRALRAQADK FQYQHEMKNTLEKEPNLTLLQGIVERLIVEDGECRGVITQTGAHYRAKAVVMTTGTYL RGRIILGDLSYSSGPNNQQPSIKLSEHLEELGFDLVRFKTGTPPRVKSDTIDYSKTEI QPGDDVPRAFSYETVEYITDQLPCWLTYTSPETHEIIDSNLHRSPMYSGMIKGTGPRY CPSIEDKVVRFNDKPRHQIFLEPEGRNTQEVYVQGLSTSLPEDVQQRMLATIPGLENV QMMRAGYAIEYDAIVPTQLWPTLETKKITNLYTAGQINGTSGYEEAAGQGIMAGINAG RKALGKEEVILSRSDAYIGVLIDDLVTKGTNEPYRLLTSRAEYRLLLRHDNADLRLTE IGHRIGLISDERYAAFEKKKAAIEAEKKRLHSVIIKPSPENQEYIRSLGGSELKDGVR GTDLMKRPEMNYETVTKLAPPEVPVPQDVAEQVEIQVKYEGYIEKSLQQVEKLKKMEN KKIPDRIDYDAIKGIATEARQKLKNVRPLSVAQASRISGVNPADISILLVYLEQGRIA KIAE*" /label="trmF CDS" gene complement(3826858..3828744) /gene="trmF" /locus_tag="BSU_41010" /old_locus_tag="BSU41010" /label="trmF gene" CDS complement(3828765..3830144) /gene="mnmE" /locus_tag="BSU_41020" /old_locus_tag="BSU41020" /EC_number="3.6.-.-" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15522079, 15616586, 19052377, 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA modification GTPase and tRNA-U34 5-formylation enzyme" /protein_id="NP_391982.1" /db_xref="EnsemblGenomes-Gn:BSU41020" /db_xref="EnsemblGenomes-Tr:CAB16139" /db_xref="GOA:P25811" /db_xref="InterPro:IPR004520" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR018948" /db_xref="InterPro:IPR025867" /db_xref="InterPro:IPR027368" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031168" /db_xref="SubtiList:BG10060" /db_xref="UniProtKB/Swiss-Prot:P25811" /translation="MDTIAAISTPMGEGAIAIVRLSGPEAIQIADKIYKGPKGKTLSS VESHTIHYGHIVDRPSDRVVEEVMVSVLKAPRTFTREDVIEINCHGGIVTVNQVLQLA LREGARLAEPGEFTKRAFLNGRIDLSQAEAVMDLIRAKTDRAMNVAMNQMEGRLSALV RRLRSEILETLAHVEVNIDYPEYDDVEEMTHQILVEKATAVKKEIETLLRTSEQGKIL REGLSTVIIGRPNVGKSSLLNSLVHEAKAIVTDIPGTTRDVIEEYVNVRGVPLRLVDT AGIRETEDIVERIGVERSRQVLKEADLILLVLNYSEELSEEDVKLFEAVEGMDVIVIL NKTDLEPKIDTERVRELANGRPVVTTSLLKEEGINDLEEAIQSLFYTGAIESGDLTYV SNTRHITILQQAKRAIEDALSGIEQDVPIDMVQIDLTRCWELLGEIIGDSVHESLIDQ LFSQFCLGK*" /label="mnmE CDS" gene complement(3828765..3830144) /gene="mnmE" /locus_tag="BSU_41020" /old_locus_tag="BSU41020" /label="mnmE gene" S_feature complement(3830145..3830275) /Source="Nicolas_S_feature" /locus_tag="new_4212890_4213020_c" /HighExp="dia15, Diami, LBGstat, H2O2, Paraq, dia5, G180, T0.30H, LBGexp, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1578" promotor_-10 complement(3830267..3830286) /Source="Nicolas_upshift_promotors" /id="U3236" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.596403596403596" /psig=1 /xcortree=2527 /SigmaFactorBS="gataaaaaggaagttcaggaaataaaattAATTGttattcac atgtggaTAAGTTAAAGTAATAAGGGAcgaatttctatttctgtggataacaaatctt c" /listShort="S1578, trmE, trmF, rsmG, S1577, noc" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3830275) /Source="Nicolas_upshifts" /id="U3236" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.596403596403596" /psig=1 /xcortree=2527 /SigmaFactorBS="gataaaaaggaagttcaggaaataaaattAATTGttattcac atgtggaTAAGTTAAAGTAATAAGGGAcgaatttctatttctgtggataacaaatctt c" /listShort="S1578, trmE, trmF, rsmG, S1577, noc" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3830302..3830306) /Source="Nicolas_upshift_promotors" /id="U3236" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.596403596403596" /psig=1 /xcortree=2527 /SigmaFactorBS="gataaaaaggaagttcaggaaataaaattAATTGttattcac atgtggaTAAGTTAAAGTAATAAGGGAcgaatttctatttctgtggataacaaatctt c" /listShort="S1578, trmE, trmF, rsmG, S1577, noc" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3830330..3830349) /Source="Nicolas_upshift_promotors" /id="U3237" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=2014 /SigmaFactorBS="tctacttttcctagtaatatcaaggttttgCCGTTTAAgttt tttctttttAGGTGTATCCTGTTGATAAAaaggaagttcaggaaataaaattaattgt t" /GFF_Attribute="listShort" /listLong="S1578, trmE, trmF, rsmG, S1577, noc" /label="promotor_-10" upshifts complement(3830340) /Source="Nicolas_upshifts" /id="U3237" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=2014 /SigmaFactorBS="tctacttttcctagtaatatcaaggttttgCCGTTTAAgttt tttctttttAGGTGTATCCTGTTGATAAAaaggaagttcaggaaataaaattaattgt t" /GFF_Attribute="listShort" /listLong="S1578, trmE, trmF, rsmG, S1577, noc" /label="upshifts" promotor_-35 complement(3830363..3830370) /Source="Nicolas_upshift_promotors" /id="U3237" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=2014 /SigmaFactorBS="tctacttttcctagtaatatcaaggttttgCCGTTTAAgttt tttctttttAGGTGTATCCTGTTGATAAAaaggaagttcaggaaataaaattaattgt t" /GFF_Attribute="listShort" /listLong="S1578, trmE, trmF, rsmG, S1577, noc" /label="promotor_-35" promotor_-35 3830430..3830436 /Source="Nicolas_upshift_promotors" /id="U3238" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.576423576423576" /psig="0.685314685314685" /xcortree=2972 /SigmaFactorBS="atattactaggaaaagtagatttttcggatacaaaaaaaccg aaatccaATTTTTAtcggacttcggtttTATGCTATCTTTTATGGGAAataacgagat g" /listShort="S1579" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3830441..3832726 /Source="Nicolas_S_feature" /locus_tag="new_4213186_4215471" /HighExp="T0.30H, C30, T1.0H, T1.30H, S2, T0.0H, T-1.10H, T-0.40H, T-1.40H, C90" /AntisenseName="oxaAA" /AntisenseCor="-0.20593684080740801" /AntisenseRegPval="-3.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.685" /TUlongSig="NA" /TUlongPSig="NA" /label="S1579" upshifts 3830441 /Source="Nicolas_upshifts" /id="U3238" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.576423576423576" /psig="0.685314685314685" /xcortree=2972 /SigmaFactorBS="atattactaggaaaagtagatttttcggatacaaaaaaaccg aaatccaATTTTTAtcggacttcggtttTATGCTATCTTTTATGGGAAataacgagat g" /listShort="S1579" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3830451..3830470 /Source="Nicolas_upshift_promotors" /id="U3238" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.576423576423576" /psig="0.685314685314685" /xcortree=2972 /SigmaFactorBS="atattactaggaaaagtagatttttcggatacaaaaaaaccg aaatccaATTTTTAtcggacttcggtttTATGCTATCTTTTATGGGAAataacgagat g" /listShort="S1579" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(3830455..3831081) /gene="jag" /locus_tag="BSU_41030" /old_locus_tag="BSU41030" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1487728, 12813085, 26883633, 27776484; Product type f: factor" /codon_start=1 /transl_table=11 /product="SpoIIIJ-associated RNA/ssDNA-binding protein" /protein_id="NP_391983.1" /db_xref="EnsemblGenomes-Gn:BSU41030" /db_xref="EnsemblGenomes-Tr:CAB16140" /db_xref="GOA:Q01620" /db_xref="InterPro:IPR001374" /db_xref="InterPro:IPR004087" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR032782" /db_xref="InterPro:IPR034079" /db_xref="InterPro:IPR036867" /db_xref="SubtiList:BG10061" /db_xref="UniProtKB/Swiss-Prot:Q01620" /translation="MRNVTAAGRNVDEAVQSGLQELGLTKDKVEITVIEEGNKGFLGI FGKKPAIVKLVEKIDPIQQAKLYLQTIAEAIAGKSDVTVQESKKTVRYHITGEKAALL IGKRGQTLNALETLTQLALNRYPGQYKNVTVDAENYRLKRKETLSQLAIKLADQVLKT KKSIQLEPMPSSERKIIHDTLSGYANHQIKTYSMGEGENRHLVISHKR*" /label="jag CDS" gene complement(3830455..3831081) /gene="jag" /locus_tag="BSU_41030" /old_locus_tag="BSU41030" /label="jag gene" downshifts complement(3830472) /Source="Nicolas_upshifts" /id="D2126" /incds=0 /nref=229 /ntot=258 /MaxReadThrough="2.29192" /MaxDrop="6.32351" /score="24.2602773" /energy="-14.1" /TU="NA" /idTUdmin="U3239" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3831078..3831863) /gene="oxaAA" /locus_tag="BSU_41040" /old_locus_tag="BSU41040" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11889108, 12586834, 15654078, 15671040, 15849754, 15995216, 16850406, 24739968, 25133632, 25313395, 25359772, 25855636" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11889108, 12586834, 15654078, 15671040, 15849754, 15995216, 16850406, 24739968, 25133632, 25313395, 25359772, 25855636; Product type f: factor" /codon_start=1 /transl_table=11 /product="Sec-independent factor for membrane protein insertion (YidC/SpoIIIJ family)" /protein_id="NP_391984.1" /db_xref="EnsemblGenomes-Gn:BSU41040" /db_xref="EnsemblGenomes-Tr:CAB16141" /db_xref="GOA:Q01625" /db_xref="InterPro:IPR001708" /db_xref="InterPro:IPR023060" /db_xref="InterPro:IPR028055" /db_xref="SubtiList:BG10062" /db_xref="UniProtKB/Swiss-Prot:Q01625" /translation="MLLKRRIGLLLSMVGVFMLLAGCSSVKEPITADSPHFWDKYVVY PLSELITYVAKLTGDNYGLSIILVTILIRLLILPLMIKQLRSSKAMQALQPEMQKLKE KYSSKDQKTQQKLQQETMALFQKHGVNPLAGCFPILIQMPILIGFYHAIMRTQAISEH SFLWFDLGEKDPYYILPIVAGVATFVQQKLMMAGNAQQNPQMAMMLWIMPIMIIVFAI NFPAALSLYWVVGNLFMIAQTFLIKGPDIKKNPEPQKAGGKKK*" /label="oxaAA CDS" gene complement(3831078..3831863) /gene="oxaAA" /locus_tag="BSU_41040" /old_locus_tag="BSU41040" /label="oxaAA gene" promotor_-10 complement(3831908..3831927) /Source="Nicolas_upshift_promotors" /id="U3239" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2262 /SigmaFactorBS="taaaagcgcttcctttctggttgatcagaaaaagaCACCATT taaaactgaaaGATGCTAAAATACATACAAGtatgctttgcaataaaagagtgtaaag a" /listShort="oxaAA, jag" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3831920) /Source="Nicolas_upshifts" /id="U3239" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2262 /SigmaFactorBS="taaaagcgcttcctttctggttgatcagaaaaagaCACCATT taaaactgaaaGATGCTAAAATACATACAAGtatgctttgcaataaaagagtgtaaag a" /listShort="oxaAA, jag" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3831922..3832007) /Source="Nicolas_S_feature" /locus_tag="new_4214667_4214752_c" /HighExp="G135, G180, H2O2, Oxctl, Paraq, G150, Cold, LPh, LBGexp, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.993, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1580" promotor_-35 complement(3831939..3831945) /Source="Nicolas_upshift_promotors" /id="U3239" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2262 /SigmaFactorBS="taaaagcgcttcctttctggttgatcagaaaaagaCACCATT taaaactgaaaGATGCTAAAATACATACAAGtatgctttgcaataaaagagtgtaaag a" /listShort="oxaAA, jag" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3832008..3832358) /gene="rnpA" /locus_tag="BSU_41050" /old_locus_tag="BSU41050" /EC_number="3.1.26.5" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 16061811, 16163391, 16980484, 17299131, 21347352, 24580115; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein component of ribonuclease P (RNase P) (substrate specificity)" /protein_id="NP_391985.1" /db_xref="EnsemblGenomes-Gn:BSU41050" /db_xref="EnsemblGenomes-Tr:CAB16142" /db_xref="GOA:P25814" /db_xref="InterPro:IPR000100" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020539" /db_xref="InterPro:IPR020568" /db_xref="PDB:1A6F" /db_xref="PDB:4JG4" /db_xref="SubtiList:BG10063" /db_xref="UniProtKB/Swiss-Prot:P25814" /translation="MKKRNRLKKNEDFQKVFKHGTSVANRQFVLYTLDQPENDELRVG LSVSKKIGNAVMRNRIKRLIRQAFLEEKERLKEKDYIIIARKPASQLTYEETKKSLQH LFRKSSLYKKSSSK*" /label="rnpA CDS" gene complement(3832008..3832358) /gene="rnpA" /locus_tag="BSU_41050" /old_locus_tag="BSU41050" /label="rnpA gene" S_feature complement(3832359..3832509) /Source="Nicolas_S_feature" /locus_tag="new_4215104_4215254_c" /HighExp="G135, G180, Oxctl, H2O2, Paraq, Cold, G150, C30, LPh, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.993, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1581" CDS complement(3832510..3832644) /gene="rpmH" /locus_tag="BSU_41060" /old_locus_tag="BSU41060" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7539334, 9371771, 12682299, 23002217, 25182490" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7539334, 9371771, 12682299, 23002217, 25182490; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L34" /protein_id="NP_391986.1" /db_xref="EnsemblGenomes-Gn:BSU41060" /db_xref="EnsemblGenomes-Tr:CAB16143" /db_xref="GOA:P05647" /db_xref="InterPro:IPR000271" /db_xref="InterPro:IPR020939" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10064" /db_xref="UniProtKB/Swiss-Prot:P05647" /translation="MKRTFQPNNRKRSKVHGFRSRMSSKNGRLVLARRRRKGRKVLSA *" /label="rpmH CDS" gene complement(3832510..3832644) /gene="rpmH" /locus_tag="BSU_41060" /old_locus_tag="BSU41060" /label="rpmH gene" promotor_no_box 3832668..3832768 /Source="Nicolas_upshift_promotors" /id="U3241" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.467532467532468" /psig="0.047952047952048" /xcortree=1495 /SigmaFactorBS="agctgttaaagacagtcttacttattatatttgcgttaccta ttcattgtcaacttcactagtgcttttatttcttgcaaccataataggataccatacc t" /listShort="S1583" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-10 complement(3832680..3832699) /Source="Nicolas_upshift_promotors" /id="U3240" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.587412587412587" /psig="0.993006993006993" /xcortree=2640 /SigmaFactorBS="tggttgcaagaaataaaagcactagtgaAGTTGACAatgaat aggtaacgcAAATATAATAAGTAAGACTGtctttaacagctattcctcgagggaggtg t" /listShort="rpmH, S1581, rnpA, S1580, oxaAA, jag" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3832690) /Source="Nicolas_upshifts" /id="U3240" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.587412587412587" /psig="0.993006993006993" /xcortree=2640 /SigmaFactorBS="tggttgcaagaaataaaagcactagtgaAGTTGACAatgaat aggtaacgcAAATATAATAAGTAAGACTGtctttaacagctattcctcgagggaggtg t" /listShort="rpmH, S1581, rnpA, S1580, oxaAA, jag" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3832692..3832760) /Source="Nicolas_S_feature" /locus_tag="new_4215437_4215505_c" /HighExp="Oxctl, G180, Paraq, H2O2, LBGstat, GM 120, MG-0.2, HPh, G135, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1582" promotor_-35 complement(3832715..3832722) /Source="Nicolas_upshift_promotors" /id="U3240" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.587412587412587" /psig="0.993006993006993" /xcortree=2640 /SigmaFactorBS="tggttgcaagaaataaaagcactagtgaAGTTGACAatgaat aggtaacgcAAATATAATAAGTAAGACTGtctttaacagctattcctcgagggaggtg t" /listShort="rpmH, S1581, rnpA, S1580, oxaAA, jag" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3832728..>3832861 /Source="Nicolas_S_feature" /locus_tag="new_4215473_4215670" /HighExp="T0.30H, C30, T1.0H, T1.30H, T0.0H, T-0.40H, S2, T-1.10H, Pyr, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.048" /TUlongSig="NA" /TUlongPSig="NA" /label="S1583" upshifts 3832728 /Source="Nicolas_upshifts" /id="U3241" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.467532467532468" /psig="0.047952047952048" /xcortree=1495 /SigmaFactorBS="agctgttaaagacagtcttacttattatatttgcgttaccta ttcattgtcaacttcactagtgcttttatttcttgcaaccataataggataccatacc t" /listShort="S1583" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3832746..3832765) /Source="Nicolas_upshift_promotors" /id="U3242" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=2591 /SigmaFactorBS="cttttttccgtaaaattaaggaatctaaaaaataaGGTTTcg aaagttgaaaaggTATGGTATCCTATTATGGTTgcaagaaataaaagcactagtgaag t" /listShort="S1582, rpmH, S1581, rnpA, S1580, oxaAA, jag" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3832760) /Source="Nicolas_upshifts" /id="U3242" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=2591 /SigmaFactorBS="cttttttccgtaaaattaaggaatctaaaaaataaGGTTTcg aaagttgaaaaggTATGGTATCCTATTATGGTTgcaagaaataaaagcactagtgaag t" /listShort="S1582, rpmH, S1581, rnpA, S1580, oxaAA, jag" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3832781..3832785) /Source="Nicolas_upshift_promotors" /id="U3242" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=2591 /SigmaFactorBS="cttttttccgtaaaattaaggaatctaaaaaataaGGTTTcg aaagttgaaaaggTATGGTATCCTATTATGGTTgcaagaaataaaagcactagtgaag t" /listShort="S1582, rpmH, S1581, rnpA, S1580, oxaAA, jag" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3832862..3833009 /locus_tag="new_1_148" /created_by="stephanmichalik" /label="S1" S_feature complement(3832885..3833158) /locus_tag="new_24_297_c" /created_by="stephanmichalik" /label="S2" S_feature 3833011..3833270 /locus_tag="new_150_409" /created_by="stephanmichalik" /label="S3" ORIGIN 1 atggaaaata tattagacct gtggaaccaa gcccttgctc aaatcgaaaa aaagttgagc 61 aaaccgagtt ttgagacttg gatgaagtca accaaagccc actcactgca aggcgataca 121 ttaacaatca cggctcccaa tgaatttgcc agagactggc tggagtccag atacttgcat 181 ctgattgcag atactatata tgaattaacc ggggaagaat tgagcattaa gtttgtcatt 241 cctcaaaatc aagatgttga ggactttatg ccgaaaccgc aagtcaaaaa agcggtcaaa 301 gaagatacat ctgattttcc tcaaaatatg ctcaatccaa aatatacttt tgatactttt 361 gtcatcggat ctggaaaccg atttgcacat gctgcttccc tcgcagtagc ggaagcgccc 421 gcgaaagctt acaacccttt atttatctat gggggcgtcg gcttagggaa aacacactta 481 atgcatgcga tcggccatta tgtaatagat cataatcctt ctgccaaagt ggtttatctg 541 tcttctgaga aatttacaaa cgaattcatc aactctatcc gagataataa agccgtcgac 601 ttccgcaatc gctatcgaaa tgttgatgtg cttttgatag atgatattca atttttagcg 661 gggaaagaac aaacccagga agaatttttc catacattta acacattaca cgaagaaagc 721 aaacaaatcg tcatttcaag tgaccggccg ccaaaggaaa ttccgacact tgaagacaga 781 ttgcgctcac gttttgaatg gggacttatt acagatatca caccgcctga tctagaaacg 841 agaattgcaa ttttaagaaa aaaggccaaa gcagagggcc tcgatattcc gaacgaggtt 901 atgctttaca tcgcgaatca aatcgacagc aatattcggg aactcgaagg agcattaatc 961 agagttgtcg cttattcatc tttaattaat aaagatatta atgctgatct ggccgctgag 1021 gcgttgaaag atattattcc ttcctcaaaa ccgaaagtca ttacgataaa agaaattcag 1081 agggtagtag gccagcaatt taatattaaa ctcgaggatt tcaaagcaaa aaaacggaca 1141 aagtcagtag cttttccgcg tcaaatcgcc atgtacttat caagggaaat gactgattcc 1201 tctcttccta aaatcggtga agagtttgga ggacgtgatc atacgaccgt tattcatgcg 1261 catgaaaaaa tttcaaaact gctggcagat gatgaacagc ttcagcagca tgtaaaagaa 1321 attaaagaac agcttaaata gcaggaccgg ggatcaatcg gggaaagtgt gaataacttt 1381 tcggaagtca tacacagtct gtccacatgt ggataggctg tgtttcctgt ctttttcaca 1441 acttatccac aaatccacag gccctactat tacttctact attttttata aatatatata 1501 ttaatacatt atccgttagg aggataaaaa tgaaattcac gattcaaaaa gatcgtcttg 1561 ttgaaagtgt ccaagatgta ttaaaagcag tttcatccag aaccacgatt cccattctga 1621 ctggtattaa aattgttgca tcagatgatg gagtatcctt tacagggagt gactcagata 1681 tttctattga atccttcatt ccaaaagaag aaggagataa agaaatcgtc actattgaac 1741 agcccggaag catcgtttta caggctcgct tttttagtga aattgtaaaa aaattgccga 1801 tggcaactgt agaaattgaa gtccaaaatc agtatttgac gattatccgt tctggtaaag 1861 ctgaatttaa tctaaacgga ctggatgctg atgaatatcc gcacttgccg cagattgaag 1921 agcatcatgc gattcagatc ccaactgatt tgttaaaaaa tctaatcaga caaacagtat 1981 ttgcagtgtc cacctcagaa acacgcccta tcttgacagg tgtaaactgg aaagtggagc 2041 aaagtgaatt attatgcact gcaacggata gccaccgtct tgcattaaga aaggcgaaac 2101 ttgatattcc agaagacaga tcttataacg tcgtgattcc gggaaaaagt ttaactgaac 2161 tcagcaagat tttagatgac aaccaggaac ttgtagatat cgtcatcaca gaaacccaag 2221 ttctgtttaa agcgaaaaac gtcttgttct tctcacggct tctggacggg aattatccag 2281 acacaaccag cctgattccg caagacagca aaacagaaat cattgtgaac acaaaagaat 2341 tccttcaggc cattgatcgt gcatctcttt tagctagaga gggacgcaac aacgttgtaa 2401 aactgtccgc aaaaccggct gaatccattg aaatttcttc caattcgcca gaaatcggta 2461 aagttgtgga agcaattgtt gcggatcaaa ttgaaggtga ggaattaaat atctctttta 2521 gtccaaaata tatgctggat gcactaaagg tgcttgaagg agcagaaata cgcgtaagct 2581 ttacaggcgc aatgagacct ttcttaattc gcacgccgaa tgatgaaacg attgtacagc 2641 ttatccttcc tgtcagaacc tattaatccg atacactgct gccgacccgt cggcagcttt 2701 tctattcggt atctgctccg acaagttttc cctttcccta attcgttttt ttttagtaca 2761 attagatatt agtgatattt gaaagaggtc gatataatgg caaatccgat ttcaattgat 2821 acagagatga ttacactcgg acaattctta aaattagccg atgtgattca gtctggcggt 2881 atggcgaagt ggtttttaag cgagcatgaa gtgcttgtga acgatgagcc ggacaaccgc 2941 cggggcagaa agctgtatgt tggagatgtg gtagagattg aaggatttgg ttcatttcaa 3001 gtcgtcaatt aaagcgggtg acactgattg tatatccaga acttagaact gacatcttac 3061 cgcaactacg accatgctga acttcaattt gaaaataaag taaatgtgat catcggagaa 3121 aacgcccagg ggaagacaaa cctcatggag gcgatctatg tcttgtccat ggcgaaatcg 3181 caccggacat caaatgacaa agaacttata cggtgggaca aagactatgc taaaatagag 3241 ggaagagtga tgaagcaaaa cggggcgatc ccgatgcagc tcgtcatctc caaaaagggt 3301 aaaaagggca aggtcaatca tattgaacag caaaagctca gccagtatgt cggggccctc 3361 aacaccatta tgttcgcgcc ggaagattta aatcttgtaa agggaagccc tcaagtgaga 3421 aggcggtttc ttgacatgga aatcggacag gtttctcccg tctaccttca tgatctttct 3481 ctttaccaga aaatcctttc ccagcggaat cattttttga aacagctgca aacaagaaaa 3541 caaactgacc ggacgatgct cgatgttctg accgatcagc ttgtagaagt tgcagcaaaa 3601 gtcgtcgtaa aacgcctgca gtttacagca cagctcgaga aatgggcgca gcccatccat 3661 gcaggcatct caagagggct tgaagaactg accctgaaat accatacagc tcttgatgta 3721 tcagatcccc tagatttgtc gaaaatagga gatagctatc aagaagcgtt ttctaaatta 3781 agagaaaaag aaattgagcg tggtgtgacg ctgtcagggc ctcatcgcga tgatgttctt 3841 ttctatgtga acggacgcga tgtgcagacg tatggttctc aaggacagca gcgaacgacg 3901 gcgttgtccc ttaagctggc ggagattgac ctgatccatg aagaaatcgg agaatatccc 3961 attttactat tggatgatgt actgagtgaa ctggatgatt atcgccagtc acacttgctt 4021 catacgatcc aaggccgtgt acaaacgttt gtcacaacga caagcgttga tggcattgat 4081 cacgaaacct tacgtcaagc aggaatgttc cgtgtgcaaa atggtgcgtt agtgaagtga 4141 agaaatgagg tgagcaattg tatattcatt taggtgatga ctttgtggtt tcaacacgag 4201 atattgtcgg catttttgac tttaaagcca acatgtcgcc tattgttgaa gaatttctga 4261 aaaaacagaa acacaaggtg gtgccttccg taaacggcac gcccaaatct atcgtagtca 4321 cggttcagaa tatatattac tctcccttat cttccagcac attaaaaaaa cgtgcgcaat 4381 ttatgtttga aatagattct tagaaatttt ttatcacgaa tatatcgttt agaaaagtgt 4441 aggtgaatga cgtggctatg gaacagcagc aaaacagtta tgatgaaaat cagatacagg 4501 tactagaagg attggaagct gttcgtaaaa gaccggggat gtatatcggt tcgacaaaca 4561 gcaaaggcct tcaccacttg gtatgggaaa ttgtcgacaa tagtattgac gaagccctcg 4621 ccggttattg tacggatatc aatatccaaa tcgaaaaaga caacagtatc acggttgtag 4681 ataatggccg cggtattcca gtcggtattc atgaaaaaat gggccgtcct gcggtagaag 4741 tcattatgac ggtgcttcat gccggaggaa aatttgacgg aagcggctat aaagtatccg 4801 gaggattaca cggtgtaggt gcgtcggtcg taaacgcact atcaacagag cttgatgtga 4861 cggttcaccg tgacggtaaa attcaccgcc aaacctataa acgcggagtt ccggttacag 4921 accttgaaat cattggcgaa acggatcata caggaacgac gacacatttt gtcccggacc 4981 ctgaaatttt ctcagaaaca accgagtatg attacgatct gcttgccaac cgcgtgcgtg 5041 aattagcctt tttaacaaag ggcgtaaaca tcacgattga agataaacgt gaaggacaag 5101 agcgcaaaaa tgaataccat tacgaaggcg gaattaaaag ttatgtagag tatttaaacc 5161 gctctaaaga ggttgtccat gaagagccga tttacattga aggcgaaaag gacggcatta 5221 cggttgaagt ggctttgcaa tacaatgaca gctacacaag caacatttac tcgtttacaa 5281 acaacattaa cacgtacgaa ggcggtaccc atgaagctgg cttcaaaacg ggcctgactc 5341 gtgttatcaa cgattacgcc agaaaaaaag ggcttattaa agaaaatgat ccaaacctaa 5401 gcggagatga cgtaagggaa gggctgacag cgattatttc aatcaaacac cctgatccgc 5461 agtttgaggg ccaaacaaaa acaaagctgg gcaactcaga agcacggacg atcaccgata 5521 cgttattttc tacggcgatg gaaacattta tgctggaaaa tccagatgca gccaaaaaaa 5581 ttgtcgataa aggtttaatg gcggcaagag caagaatggc tgcgaaaaaa gcgcgtgaac 5641 taacacgccg taagagtgct ttggaaattt caaacctgcc cggtaagtta gcggactgct 5701 cttcaaaaga tccgagcatc tccgagttat atatcgtaga gggtgactct gccggaggat 5761 ctgctaaaca aggacgcgac agacatttcc aagccatttt gccgcttaga ggtaaaatcc 5821 taaacgttga aaaggccaga ctggataaaa tcctttctaa caacgaagtt cgctctatga 5881 tcacagcgct cggcacaggt atcggagaag acttcaacct tgagaaagcc cgttaccaca 5941 aagttgtcat tatgacagat gccgatgttg acggcgcgca catcagaaca ctgctgttaa 6001 cgttctttta cagatatatg cgccaaatta tcgaaaatgg ctacgtgtac attgcgcagc 6061 cgccgctcta caaggttcaa caggggaaac gcgttgaata tgcatacaat gacaaggagc 6121 ttgaagagct gttaaaaact cttcctcaaa cgcctaagcc tggactgcag cgttacaaag 6181 gtcttggtga aatgaatgcc acccagctat gggagacaac catggatcct agctccagaa 6241 cacttcttca ggtaactctt gaagatgcaa tggatgcgga tgagactttt gaaatgctta 6301 tgggcgacaa ggtagaaccg cgccgaaact tcatagaagc gaatgcgaga tacgttaaaa 6361 atcttgacat ctaatcataa aaagccttat ttccaataag aaataaggct tttttctgaa 6421 caagatcaga tgcagcgatg cctgcaatac ctatatattc tagcaattta atgtgtataa 6481 tcataagttt attgatataa tggagaatag tgaaatcgta ttgaaggtca taatggacaa 6541 tctactccca catatttcat gtgatacttc agggaggttt tttaatgagt gaacaaaaca 6601 caccacaagt tcgtgaaata aatatcagtc aggaaatgcg tacgtccttc ttggattatg 6661 caatgagcgt tatcgtgtcc cgtgctcttc cggatgttcg tgacggttta aaaccggttc 6721 atagacggat tttgtatgca atgaatgatt taggcatgac aagtgacaag ccttataaaa 6781 aatccgcgcg tatcgttgga gaagttatcg ggaaatacca cccgcacggt gattcagcgg 6841 tatatgaatc catggtcaga atggctcagg atttcaacta ccgttatatg ctcgttgacg 6901 gtcacggaaa cttcggttct gttgacggag actcagcggc ggccatgcgt tatacagaag 6961 cacgaatgtc taaaatctca atggagattc ttcgcgacat cacaaaagac acaatcgatt 7021 accaggataa ctatgacggg tcagaaagag aacctgtcgt tatgccttca aggttcccga 7081 atctgctcgt gaacggtgct gccggcattg cggtaggtat ggcaacaaac attcctccgc 7141 accagctggg agaaatcatt gacggtgtac ttgctgttag tgagaatccg gacattacaa 7201 ttccagagct tatggaagtc attccagggc ctgatttccc gaccgcgggt caaatcttgg 7261 gacgcagcgg tatccggaaa gcatacgaat caggccgagg ctctatcacg atccgggcaa 7321 aagctgagat cgaacaaaca tcttcgggta aagaaagaat tatcgttaca gagttacctt 7381 accaagtaaa taaggcgaaa ttaattgaga aaattgctga tctcgtaagg gacaaaaaga 7441 tagagggtat cacagatctg cgtgatgagt cagatcgtac aggtatgaga attgtcattg 7501 aaatcagacg cgatgccaat gcgaatgtta tcttaaacaa tctgtacaaa caaactgctc 7561 tacaaacatc ttttggcatc aacctgcttg cgcttgttga tggccagccg aaagttttaa 7621 ctcttaagca atgcctggag cattaccttg accatcaaaa agttgtcatt agacgccgta 7681 ctgcttatga attgcgtaaa gcagaagcga gagctcatat cttggaagga ttgagagttg 7741 cactggatca tctcgatgca gttatctccc ttatccgtaa ttctcaaacg gctgaaattg 7801 cgagaacagg tttaattgaa caattctcac tgacagagaa gcaagcacaa gcgatccttg 7861 acatgaggct ccagcgttta acgggactgg aacgtgaaaa gatcgaagaa gaataccagt 7921 ctcttgttaa attaattgca gagctaaaag acatcttggc aaatgaatat aaagtgcttg 7981 agatcattcg tgaagaactc acggaaatca aagagcgttt taacgatgaa agacgtactg 8041 agatcgtcac ttctggactg gagacaattg aagatgaaga tctcatcgag agagaaaata 8101 tcgtagttac tctgacgcac aacggatacg tcaaacgtct tcctgcatca acttaccgca 8161 gtcaaaaacg gggcggaaaa ggtgtacaag gtatgggaac aaacgaagat gatttcgttg 8221 aacatttgat ctctacgtca actcatgaca cgattctctt cttctcgaac aaggggaaag 8281 tgtatcgtgc aaaagggtat gaaatccctg aatacggcag aacggcaaaa ggaatcccga 8341 ttattaacct gctggaggta gaaaagggtg agtggatcaa cgcgattatt ccagtcacgg 8401 aattcaatgc ggagctttac ctcttcttca ctacaaagca tggggtttca aaacgaacat 8461 cgctatctca attcgctaat atccgcaaca atggtctaat tgctctgagt cttcgtgaag 8521 atgatgaact gatgggtgta cgtctgactg acggcacaaa acaaatcatc attggaacga 8581 aaaacggttt actgattcgt ttccctgaaa cagatgtccg agagatggga agaactgcgg 8641 cgggcgtaaa aggcatcacc ctgacggatg acgacgttgt tgtcggcatg gagattttag 8701 aggaagaatc acacgtcctt atcgtaactg aaaaagggta cggaaaacga actcctgctg 8761 aagagtacag aacccaaagc cggggcggaa aaggactcaa aacagcgaaa atcaccgaga 8821 acaacggcca actagtagca gtgaaagcta ctaaaggtga agaggatcta atgattatta 8881 cagctagcgg cgtactcatc agaatggaca tcaatgatat ctccatcacc ggacgtgtca 8941 ctcaaggtgt gcgtctcatc agaatggcag aagaagagca tgttgctaca gtagctttag 9001 ttgagaaaaa cgaagaagat gagaatgaag aagaacaaga agaagtgtga aaaaaagcgc 9061 agctgaaata gctgcgcttt tttgtgtcat aaccctttac agtcataaaa attatggtat 9121 aatcatttct gttgtctttt taaagacaca agcatgacca ttatgactag taaaaacttt 9181 ttcaaaaaag tattgaccta gttaactaaa aatgttacta ttaagtagtc gctttgagag 9241 aagcacacaa agttctttga aaactaaaca agacaaaacg tacctgttaa ttcattttta 9301 taaatcgcac agcgatgtgc gtagtcagtc aaactagggc ctgcacgacg caggtcacac 9361 aggtgtcgcc gcaggatgcg gtgaacttaa cctgtgatcc atttatcgga gagtttgatc 9421 ctggctcagg acgaacgctg gcggcgtgcc taatacatgc aagtcgagcg gacagatggg 9481 agcttgctcc ctgatgttag cggcggacgg gtgagtaaca cgtgggtaac ctgcctgtaa 9541 gactgggata actccgggaa accggggcta ataccggatg gttgtttgaa ccgcatggtt 9601 caaacataaa aggtggcttc ggctaccact tacagatgga cccgcggcgc attagctagt 9661 tggtgaggta acggctcacc aaggcgacga tgcgtagccg acctgagagg gtgatcggcc 9721 acactgggac tgagacacgg cccagactcc tacgggaggc agcagtaggg aatcttccgc 9781 aatggacgaa agtctgacgg agcaacgccg cgtgagtgat gaaggttttc ggatcgtaaa 9841 gctctgttgt tagggaagaa caagtgccgt tcgaataggg cggtaccttg acggtaccta 9901 accagaaagc cacggctaac tacgtgccag cagccgcggt aatacgtagg tggcaagcgt 9961 tgtccggaat tattgggcgt aaagggctcg caggcggttt cttaagtctg atgtgaaagc 10021 ccccggctca accggggagg gtcattggaa actggggaac ttgagtgcag aagaggagag 10081 tggaattcca cgtgtagcgg tgaaatgcgt agagatgtgg aggaacacca gtggcgaagg 10141 cgactctctg gtctgtaact gacgctgagg agcgaaagcg tggggagcga acaggattag 10201 ataccctggt agtccacgcc gtaaacgatg agtgctaagt gttagggggt ttccgcccct 10261 tagtgctgca gctaacgcat taagcactcc gcctggggag tacggtcgca agactgaaac 10321 tcaaaggaat tgacgggggc ccgcacaagc ggtggagcat gtggtttaat tcgaagcaac 10381 gcgaagaacc ttaccaggtc ttgacatcct ctgacaatcc tagagatagg acgtcccctt 10441 cgggggcaga gtgacaggtg gtgcatggtt gtcgtcagct cgtgtcgtga gatgttgggt 10501 taagtcccgc aacgagcgca acccttgatc ttagttgcca gcattcagtt gggcactcta 10561 aggtgactgc cggtgacaaa ccggaggaag gtggggatga cgtcaaatca tcatgcccct 10621 tatgacctgg gctacacacg tgctacaatg gacagaacaa agggcagcga aaccgcgagg 10681 ttaagccaat cccacaaatc tgttctcagt tcggatcgca gtctgcaact cgactgcgtg 10741 aagctggaat cgctagtaat cgcggatcag catgccgcgg tgaatacgtt cccgggcctt 10801 gtacacaccg cccgtcacac cacgagagtt tgtaacaccc gaagtcggtg aggtaacctt 10861 ttaggagcca gccgccgaag gtgggacaga tgattggggt gaagtcgtaa caaggtagcc 10921 gtatcggaag gtgcggctgg atcacctcct ttctaaggat attttacgga atataagacc 10981 ttgggtctta taaacagaac gttccctgtc ttgtttagtt ttgaaggaac tttgttcctt 11041 gaataagtta agatgggcct gtagctcagc tggttagagc gcacgcctga taagcgtgag 11101 gtcggtggtt cgagtccact caggcccacc atcttatata acggggcctt agctcagctg 11161 ggagagcgcc tgctttgcac gcaggaggtc agcggttcga tcccgctagg ctccaccaac 11221 gtgttctttg aaaactagat aacagtagac atcacattca attagtaaca caagatatca 11281 catagtgatt ctttttaacg gttaagttag aaagggcgca cggtggatgc cttggcacta 11341 ggagccgatg aaggacggga cgaacaccga tatgcttcgg ggagctgtaa gcaagctttg 11401 atccggagat ttccgaatgg ggaaacccac cactcgtaat ggagtggtat ccatatctga 11461 attcatagga tatgagaagg cagacccggg gaactgaaac atctaagtac ccggaggaag 11521 agaaagcaaa tgcgattccc tgagtagcgg cgagcgaaac gggatcagcc caaaccaaga 11581 ggcttgcctc ttggggttgt aggacactct gtacggagtt acaaaggaac gaggtagatg 11641 aagaggtctg gaaaggcccg ccataggagg taacagccct gtagtcaaaa cttcgttctc 11701 tcctgagtgg atcctgagta cggcggaaca cgtgaaattc cgtcggaatc cgggaggacc 11761 atctcccaag gctaaatact ccctagtgac cgatagtgaa ccagtaccgt gagggaaagg 11821 tgaaaagcac cccggaaggg gagtgaaaga gatcctgaaa ccgtgtgcct acaagtagtc 11881 agagcccgtt aacgggtgat ggcgtgcctt ttgtagaatg aaccggcgag ttacgatctc 11941 gtgcaaggtt aagcagaaga tgcggagccg cagcgaaagc gagtctgaat agggcgcatg 12001 agtacgtggt cgtagacccg aaaccaggtg atctacccat gtccagggtg aagttcaggt 12061 aacactgaat ggaggcccga acccacgcac gttgaaaagt gcggggatga ggtgtgggta 12121 ggggtgaaat gccaatcgaa cctggagata gctggttctc tccgaaatag ctttagggct 12181 agcctcaagg taagagtctt ggaggtagag cactgattgg actaggggcc cctaccgggt 12241 taccgaattc agtcaaactc cgaatgccaa tgacttatcc ttgggagtca gactgcgagt 12301 gataagatcc gtagtcgaaa gggaaacagc ccagaccgcc agctaaggtc ccaaagtata 12361 cgttaagtgg aaaaggatgt ggagttgctt agacaaccag gatgttggct tagaagcagc 12421 caccatttaa agagtgcgta atagctcact ggtcgagtga ctctgcgccg aaaatgtacc 12481 ggggctaaac gtatcaccga agctgcggac tgttcttcga acagtggtag gagagcgttc 12541 taagggctgt gaagccagac cggaaggact ggtggagcgc ttagaagtga gaatgccggt 12601 atgagtagcg aaagaggggt gagaatcccc tccaccgaat gcctaaggtt tcctgaggaa 12661 ggctcgtccg ctcagggtta gtcgggacct aagccgaggc cgaaaggcgt aggcgatgga 12721 caacaggttg atattcctgt accacctcct caccatttga gcaatggggg gacgcaggag 12781 gatagggtaa gcgcggtatt ggatatccgc gtccaagcag ttaggctggg aaataggcaa 12841 atccgtttcc cataaggctg agctgtgatg gcgagcgaaa tatagtagcg aagttcctga 12901 ttccacactg ccaagaaaag cctctagcga ggtgagaggt gcccgtaccg caaaccgaca 12961 caggtaggcg aggagagaat cctaaggtga tcgagagaac tctcgttaag gaactcggca 13021 aaatgacccc gtaacttcgg gagaaggggt gctctgttag ggtgcaagcc cgagagagcc 13081 gcagtgaata ggcccaggcg actgtttagc aaaaacacag gtctctgcga agccgtaagg 13141 cgaagtatag gggctgacgc ctgcccggtg ctggaaggtt aagaggagcg cttagcgtaa 13201 gcgaaggtgc gaattgaagc cccagtaaac ggcggccgta actataacgg tcctaaggta 13261 gcgaaattcc ttgtcgggta agttccgacc cgcacgaaag gcgcaacgat ctgggcactg 13321 tctcaacgag agactcggtg aaattatagt acctgtgaag atgcaggtta cccgcgacag 13381 gacggaaaga ccccgtggag ctttactgca gcctgatatt gaatgttggt acagcttgta 13441 caggataggt aggagccttg gaaaccggag cgccagcttc ggtggaggca tcggtgggat 13501 actaccctgg ctgtattgac cttctaaccc gccgccctta tcgggcgggg agacagtgtc 13561 aggtgggcag tttgactggg gcggtcgcct cctaaaaggt aacggaggcg cccaaaggtt 13621 ccctcagaat ggttggaaat cattcgcaga gtgtaaaggc acaagggagc ttgactgcga 13681 gacctacaag tcgagcaggg acgaaagtcg ggcttagtga tccggtggtt ccgcatggaa 13741 gggccatcgc tcaacggata aaagctaccc cggggataac aggcttatct cccccaagag 13801 tccacatcga cggggaggtt tggcacctcg atgtcggctc atcgcatcct ggggctgtag 13861 tcggtcccaa gggttgggct gttcgcccat taaagcggta cgcgagctgg gttcagaacg 13921 tcgtgagaca gttcggtccc tatccgtcgc gggcgcagga aatttgagag gagctgtcct 13981 tagtacgaga ggaccgggat ggacgcaccg ctggtgtacc agttgttctg ccaagggcat 14041 cgctgggtag ctatgtgcgg acgggataag tgctgaaagc atctaagcat gaagcccccc 14101 tcaagatgag atttcccatt ccgcaaggaa gtaagatccc tgaaagatga tcaggttgat 14161 aggtctgagg tggaagtgtg gcgacacatg gagctgacag atactaatcg atcgaggact 14221 taaccatatt tttgaatgat gtcacacctg ttatctagtt ttgagagaac actctcaatt 14281 tgtttggtgg cgatagcgaa gaggtcacac ccgttcccat accgaacacg gaagttaagc 14341 tcttcagcgc cgatggtagt cgggggtttc cccctgtgag agtaggacgc cgccaagcaa 14401 gcttaaaccc agctcaatga gctgggtttt ttgtttgtta aaaatgaaga agaaactgtg 14461 aagcgtattt agggaatttc ttttctgata ctaataaaaa ctgctgaatt aacacgtagt 14521 catcacttat atgctgtgtt aataactcat accaccattc tgtttcatac cttgcaatca 14581 tcccaacgtt gtacaaaatc aaataatgaa ttgtcatttc gggaagcctc agaaattgct 14641 ccctttgaga agggatataa tattggttct tttccatgtc aaacaataag ctggtcgatg 14701 tccatggctc cttgtcttgt ggtgaaattt cgaacagcag cccgtgttca tttttttttg 14761 taaaagacca ttgataatga tgggacatgt attcagcaaa ccttgaatca gacattttgt 14821 aattgattac tacttcctcc ggtacaaaaa tttcgttctt atccttctca acttttgtca 14881 taaatcgttc tttctgctga aagtagaaaa tatcgctaag ttctggaatg gccattaata 14941 attttttcat ggtataccgt tcatctacta tatccgattg tccgaataaa tgtttcataa 15001 aatgtacgca taggccattc cgttgtattt tcacttcatc gtcgctaaaa caataatttt 15061 gtttctttcg ttttcttgtt gttacgccat gtgccagtac tgatgtatgg cttggataat 15121 gaggatcacg tgtaattaag catgctttga taagctgtgc cattccataa aataaaagaa 15181 tcggtttgat ttctaaggga gaatatgcgg cttgtttata aaacgattcg gcatgcttta 15241 agaaataaat aaaccgttca ctgtttttaa aagagttttt tttcgcatcg ttaataccgt 15301 ttaagatata aaccttttct agaaatttct gggttgattc aacggagtaa aatagcgcta 15361 agtctttcca ctcatgatat gtcatgtata tttcttaatc ctttccgtta tctaaatatt 15421 tcaactcttt cccgcttcct tgacatgctc ttggctagtt gataatctac atataatatt 15481 ttgccgaaaa gagggggatt tactaatgtg ggaaagtaaa ttttcaaaag aaggcttaac 15541 gttcgacgat gtgctgcttg taccagcaaa gtctgaggta cttccgcgtg atgtggattt 15601 atctgtagaa cttacaaaaa cgttaaagct aaatattcct gtcatcagcg caggtatgga 15661 cactgtaaca gaatcagcaa tggcaattgc aatggcaaga cagggcggct tgggcatcat 15721 tcacaaaaat atgtccattg aacagcaggc tgaacaagtt gataaagtaa agcgttctga 15781 gcgcggcgtt atcacaaatc ccttcttttt aactcctgat caccaagtat ttgatgcgga 15841 gcatttgatg gggaaataca gaatttccgg tgttccgatt gtaaataacg aagaagacca 15901 gaagcttgtt ggaattatta caaaccgtga ccttcgtttt atttctgact actcaatgaa 15961 aatcagcgac gtcatgacga aagaagagct agttactgca tctgtaggaa ctactctgga 16021 tgaagctgaa aagattttgc agaaacataa aattgaaaag cttcctctcg tagatgacca 16081 gaataaatta aaaggtctta tcacaattaa agacattgaa aaagtcattg agttcccgaa 16141 ctcatctaaa gacattcacg gccgcctgat cgttggcgcg gcagttggtg taactggcga 16201 tacaatgact cgcgtcaaaa agcttgttga agccaatgtt gatgtgattg ttatcgatac 16261 agctcacgga cactctcaag gcgttttaaa cacagtcaca aaaatccgtg aaacgtatcc 16321 cgaattaaac attattgctg gaaacgtggc aacagctgaa gcgacaagag cgcttatcga 16381 agctggagca gacgttgtca aagttggaat agggcctggt tcaatttgta ctacacgtgt 16441 tgtagccggc gtgggtgttc cgcaaattac agcaatttat gattgtgcga ctgaagcaag 16501 aaaacacggc aaaacaatca tcgccgacgg tgggattaaa ttctctggcg atatcactaa 16561 agcattggca gccggcggac atgctgttat gctcggaagc ttgcttgcag gcacatcaga 16621 aagccctggt gaaactgaaa tctaccaagg cagaagattt aaggtatacc gcggcatggg 16681 atcagttgct gcaatggaaa aaggaagtaa agaccgttac ttccaagaag aaaacaaaaa 16741 atttgttcct gaaggaattg aaggacgcac accttacaaa gggccagttg aagaaaccgt 16801 ttatcagcta gtcggaggcc ttcgttctgg tatggggtat tgcgggtcca aagatctgcg 16861 tgcgctaaga gaagaagctc agttcattcg catgactggc gcaggacttc gcgaaagcca 16921 tccgcatgac gtacagatta caaaagaatc acctaactat acaatttcat aataaattgt 16981 tacaaattaa aaacatttga cagggtctct gactctgtct atttttttta tactgattat 17041 gataaaattt atactgttgt gcattgaaaa tgtccttaac ggcttaatta tagatgaaga 17101 aaatgaaata cggaggtcgt acgattgaac atcaagaaat gtaaacagct actgatgtca 17161 ttggttgtgt taactctagc tgtcacgtgt ctggctccaa tgtcaaaagc gaaagcagcc 17221 agcgatccaa ttgatatcaa tgcatctgct gctattatga tcgaagcttc ttcaggtaaa 17281 attctttaca gtaaaaatgc agataagaga ctgccaattg cgagtatgac aaaaatgatg 17341 acagagtatc tgttattgga agcaattgat caaggtaaag tgaaatggga ccaaacctat 17401 acgcctgatg actatgtgta tgaaatttcc caagataaca gcttatcaaa cgttcctctt 17461 cggaaagacg ggaaatacac agtaaaagaa ttatatcaag ctacagcaat ttattctgca 17521 aatgctgctg ctattgcgat tgcagaaatc gttgccggtt ctgaaactaa gtttgttgaa 17581 aaaatgaatg caaaagcaaa agaactaggc ttaacagatt acaaatttgt taacgcaaca 17641 ggtcttgaaa acaaagatct tcacgggcat cagcctgagg ggacaagcgt aaatgaagaa 17701 agtgaagttt ctgcaaagga tatggcggtt cttgcggatc acttgattac tgactaccct 17761 gagatactgg agacttccag tatcgccaaa acgaaattca gagaaggcac cgatgatgaa 17821 atggacatgc cgaactggaa ttttatgctg aaggggcttg tcagcgagta taaaaaagcg 17881 actgtagacg gactgaaaac aggttctact gactctgcgg gttcatgctt tacaggaaca 17941 gctgaacgca acggtatgcg tgtcatcact gttgttttaa acgcaaaggg caaccttcat 18001 acaggccgtt tcgatgaaac gaaaaaaatg tttgattatg ctttcgacaa tttctccatg 18061 aaagaaattt atgctgaagg cgatcaagta aaaggccata aaacaatttc agttgataag 18121 ggtaaagaga aagaagtagg cattgtgaca aacaaggcgt tctctcttcc tgtcaaaaat 18181 ggtgaagaaa agaattacaa agcgaaggtc acactgaata aagacaactt aactgctcct 18241 gtgaaaaaag gaaccaaggt tgggaagctg actgcggaat acacaggtga tgaaaaggat 18301 tacggattcc ttaacagcga tctggctggc gtagaccttg ttacaaaaga aaatgtagaa 18361 aaagcaaact ggtttgtttt gacaatgcgc agtatcggcg gattttttgc cggaatttgg 18421 ggaagcattg ttgatacggt aaccggctgg ttttaatcaa ttgaaagagc tctgatggat 18481 gttagggctc tttcgcgtaa tatactgaaa aaacccaatt tttaataaaa aatgattttc 18541 aaagcgctaa aaaccgaata aaatagtata tatgcatatg aattattgga tttctaggat 18601 acaataagga ttagaaatca tataactata ccttgattag ggggaccaag aaatggctca 18661 aacaggtact gaacgtgtaa aacgcggaat ggcagaaatg caaaaaggcg gcgtcatcat 18721 ggacgtcatc aatgcggaac aagcgaaaat cgctgaagaa gctggagctg tcgctgtaat 18781 ggcgctagaa cgtgtgccag cagatattcg cgcggctgga ggagttgccc gtatggctga 18841 ccctacaatc gtggaagaag taatgaatgc agtatctatc ccggtaatgg caaaagcgcg 18901 tatcggacat attgttgaag cgcgtgtgct tgaagctatg ggtgttgact atattgatga 18961 aagtgaagtt ctgacgccgg ctgacgaaga atttcattta aataaaaatg aatacacagt 19021 tccttttgtc tgtggctgcc gtgatcttgg tgaagcaaca cgccgtattg cggaaggtgc 19081 ttctatgctt cgcacaaaag gtgagcctgg aacaggtaat attgttgagg ctgttcgcca 19141 tatgcgtaaa gttaacgctc aagtgcgcaa agtagttgcg atgagtgagg atgagctaat 19201 gacagaagcg aaaaacctag gtgctcctta cgagcttctt cttcaaatta aaaaagacgg 19261 caagcttcct gtcgttaact ttgccgctgg cggcgtagca actccagctg atgctgctct 19321 catgatgcag cttggtgctg acggagtatt tgttggttct ggtattttta aatcagacaa 19381 ccctgctaaa tttgcgaaag caattgtgga agcaacaact cactttactg attacaaatt 19441 aatcgctgag ttgtcaaaag agcttggtac tgcaatgaaa gggattgaaa tctcaaactt 19501 acttccagaa cagcgtatgc aagaacgcgg ctggtaagaa cataggagcg ctgctgacat 19561 gttaacaata ggtgtactag gacttcaagg agcagttaga gagcacatcc atgcgattga 19621 agcatgcggc gcggctggtc ttgtcgtaaa acgtccggag cagctgaacg aagttgacgg 19681 gttgattttg ccgggcggtg agagcacgac gatgcgccgt ttgatcgata cgtatcaatt 19741 catggagccg cttcgtgaat tcgctgctca gggcaaaccg atgtttggaa catgtgccgg 19801 attaattata ttagcaaaag aaattgccgg ttcagataat cctcatttag gtcttctgaa 19861 tgtggttgta gaacgtaatt catttggccg gcaggttgac agctttgaag ctgatttaac 19921 aattaaaggc ttggacgagc cttttactgg ggtattcatc cgtgctccgc atattttaga 19981 agctggtgaa aatgttgaag ttctatcgga gcataatggt cgtattgtag ccgcgaaaca 20041 ggggcaattc cttggctgct cattccatcc ggagctgaca gaagatcacc gagtgacgca 20101 gctgtttgtt gaaatggttg aggaatataa gcaaaaggca cttgtataaa acagttgaaa 20161 gctgtggaaa cttatagtac attataagca caaataaaga tcgaaaagcg ttgataggaa 20221 ctagtaggga gcctctcttt ctaagagagc cgatggttgg tgcgaatcgg tgaaagatgc 20281 tgtctgaatc catccttgag cgaaatgctg aagcgagtag gcatttacgg gataaccgtt 20341 atgtttgaaa gtggaaaacg agtctttgat ttgttttcaa tcagggtggc aacgcgagag 20401 ctctcgtccc tttatgggga tgagggctct ttttattttc gataaatcaa taaaaaaagg 20461 agtgtttcgc atgcttgata cgaaaatgct gagagcaaat tttcaagaaa ttaaagcaaa 20521 gcttgtacac aaaggcgaag acttaactga ttttgataag tttgaggcgc tggatgatag 20581 acgaagagag cttatcggca aggttgaaga gttaaaagga aaacgaaatg aagtttctca 20641 gcaggttgct gtgctgaagc gtgagaaaaa agacgcggat cacattatta aagaaatgcg 20701 tgaagtcggc gaggaaatta aaaagctcga tgaagaatta cggacagtgg aagctgagct 20761 tgatacaatc ctgctctcaa tcccgaatat tccgcatgag tctgtacctg tcggtgaaac 20821 agaagacgac aacgtagaag tgcgtaaatg gggtgaaaag ccttcatttg cttatgagcc 20881 gaagccgcac tgggatattg cggatgagct gggtattctg gattttgaac gtgctgccaa 20941 agtaacagga agccgtttcg tgttctataa aggcttaggt gctcgtctgg agcgtgcgct 21001 ttataacttt atgcttgatc tgcatgtgga tgagtataac tacactgaag tgatcccgcc 21061 atatatggta aaccgcgcaa gcatgacggg aacggggcag cttcctaaat ttgaagagga 21121 tgcatttaaa atcagagaag aagattattt cttaattcca acggcggaag tgccgattac 21181 aaacatgcat cgcgatgaaa tcctttcagg tgacagcctg ccgatcaact atgcggcatt 21241 cagtgcttgc ttccgttctg aagctggttc agcaggacgt gacacacgcg gattaattcg 21301 tcagcaccaa tttaataaag ttgagcttgt aaagtttgtg aagcctgaag attcttatga 21361 agaattagag aaacttacaa accaagcaga acgggttctt cagctgcttg agcttccata 21421 ccgtgtcatg agcatgtgta cgggtgactt aggctttacg gctgcgaaaa aatacgatat 21481 cgaagtttgg attccaagcc aagacacata tcgagaaatc tcttcttgca gcaacttcga 21541 agcgttccag gcgagacgtg cgaatattcg tttcagacgt gaagcgaaag gcaagcctga 21601 gcatgtacac acactgaacg gctcaggact ggcggttgga agaacagttg ctgctatctt 21661 agaaaattat cagcaggaag acggaagcgt tgtgattccg aaagtgcttc gtccttatat 21721 ggggaataga gaagtaatga aaccgtaaat tatggaaagg cgtgcctgac aaggtgcgcc 21781 tttttgctta tgtaaacacg gcattttcat aaaaacaaaa aaagttttta aaaatgcttg 21841 accacacgag aacatacgtg atatagttag tcttgtcgat acggaggaat acccaagtcc 21901 ggctgaaggg atcggtcttg aaaaccgaca ggggtgtcaa agcccgcggg ggttcgaatc 21961 cctcttcctc cgccatattg attttaattc taatgaaaca caagcatata ttggagattg 22021 ttttgtccgt tgcattcggt gcggcggatt ttttatttta aagaaaaagt gaatctcgac 22081 tgagattcac tttttttgat tatcatgaat aactgaagca atttgatcta caatattttc 22141 aatcgagttt tcgtcgttca gaagatcata atcttcaatg cgaagtttta aaacagggca 22201 ggcattaaaa ccgcttatcc agttctcgta gcgtgtatgc atttcttccc aataagaccg 22261 gcttgtctga agctccatct cacggccgcg ttgttcaatc cggtttaaaa tgttctccag 22321 atctccttct aaatagatca acacatctgg atgtgggaaa tacggtgtca ttaccattgc 22381 ttcgaaaagg cttgtgtaag tcttataatc aacctttgac attgtccctt tatcagcatg 22441 catttttgcg aaaattcctg tatcttcata aatcgaacga tcctgtacaa aacctccgcc 22501 ggcttcaaaa attgttttct gttctttgaa gcgttcagct aagaagtaaa tttgaaggtg 22561 aaagctccaa cgttcaaaat catgatagaa cttttccaaa tatggattat gatcgacttc 22621 ctccaacgat gttttaaatc caagccgttt agctaaagtt tttgttaaag tcgattttcc 22681 gacacctact gttcctgcta ctgtaataat tgaattctta gggatatgat gttccttcat 22741 acgataagct cctttacatg ggcggcaatg cgttcaaagt cgctcttatt caaaacgaaa 22801 tcctttgaat caccatctac ggttaacact gtaagttcag ggtctgcttc ctgcagctgc 22861 ttgatggcga cttcataatc tgaaatcagc tgctccaaat agctagtttc aatttttttc 22921 tcaaaggggc gcccgcgttt ttcaatgcgg tgtagcaatg taggcagact ggcctttatg 22981 taaatgatga aattcggctt tggcagatca tccgttagca ggtgatatat ctttttgtat 23041 ttttccagct gatgtggaga caaggttcgt tccgcaaaaa tcacattttt ataaatatga 23101 taatcagcta ttacaggctg tccctttttt aaaaagtgat cactggtgtc ttcaagctgt 23161 ttgtatctgt gacaaagaaa aaacatctcg agctggaagc tccattcctt tatattgtca 23221 taaaacttat caaggtacgg gttatcctct acaatctcat tgatcatagg gaatccgaat 23281 ttttgtgaga gcatcgttgc gagagttgtt tttcctgccc cgataggacc ttctattgca 23341 ataaaagggg ctgtattcat cggaatcctc cttatatctg aaaaacgtgc gtcagttacc 23401 gaccttcata ttgtatcaca acccttgggt gcccccatga aaaaaagacg tttccaaatt 23461 atcgaaacgt ctttttgaca acattaaatt gatcagacag cagcagccag ttttgtggaa 23521 aggaaagacc cagcttccaa tagctgatgc ctcttaaatt cagctcttta atcagattga 23581 attttgcttg aatcgagcgg gcatcctcga accatacctc gtgccttctg ttttctgcat 23641 cagtatagcg gaagaaagga gcttgagcgg tttggtcata ctgaatggaa gcattgttct 23701 gatcagctat gacaatggct tgctgagggc ttactgctct tgctggagtt ccccctgctg 23761 tatatggcag cgtccagtca tatccatata aattctggcc catgacaatt ttgttcgcag 23821 gcatttcagt caaagcatat tctatgacat cacggacagg tccaattgga gaaaccgctt 23881 gaggcggtcc gccgctatag ccccattcat atgtcatgag aacaacaaag tcgacaattt 23941 cgccatgtgc cctgtaatca tgagcttcat accacctgcc ctgctgtgtt gcacttgttt 24001 taggagcaag agccgtagaa atttctaagc cctctcgatg gaaaagatcc cttgcttcgc 24061 ggaggaattg attataggcc tctctatcct ggggccgcaa atattcaaag tcgaaatgaa 24121 tgtcacggaa gccatatctt ctggcattct cgactatttc atttagaagc cgtcttttta 24181 cagtttcgtc gttcaaaagg atccggccaa gttcatcgct gaatgcctgg ttttctaggt 24241 tcgttataat catcatcaat gttgtatttt gactttctgt aatgctcctt aaattcgtta 24301 aaggcggtgc gactaaggtt ccgttccgct gtgcctggaa gctgaatgcg ccaaggtaag 24361 ttaagtaggg cgacgcttct ctggccgcct gctggagatt ttcgctgact tgatttcctc 24421 ggggctccaa ataagcattt gattcgatgt ctcgtttagg agctggaggg atgtataaac 24481 ggaaaccaat ctgaagcacg gtatttaact ggatgcggtt aacccttgcg agctcggctg 24541 ctgttgtatt gaactgccgg gcgatggatg tcagggtatc acctcgcttc acatcataga 24601 actggccagc tattggaatg acaatggttt gtccgacaac aaggctgtcg ggattcggta 24661 tttcattcgt ttcagtgatg tcatttgtgg ttgttctgta ttgtgaagcg atagcagaaa 24721 gagtgtcgcc ttgttttacc acataaattt gaatgaaaaa cgcctccttt catatcgcta 24781 tcaatgtatg aaagaaaagc gctgatcatg tttatttttc tataatttgt tcttccgtcg 24841 taatttctgc gaaaagaaca ttctccatca tggttaaggc gaattcgtta tcttcgtcac 24901 tgtttgacgc gatacagtcc ttaggaatcg tgatgctgta ttccctcata taagcgtcat 24961 tagcggtaaa cagcacgcat atattgccgg ctatacctgt tatgataata tgtctcacct 25021 gcaactcagt aagaagggtg tgaagtgctg tttcgtagaa agcggaatgt ttcggtttga 25081 ttaaaaaata atcagcatct accggagcta tctttgtgat gatatccttg cttctttcat 25141 ttgtgcattc ttgctgtatg tttttaatgt cagcttgcca aagtccataa tgatcattga 25201 tgtaaataat cggccattca ttttgtctcg cgtgctcctt taatgataaa atatgaggaa 25261 cgattttttc tgttttttta gcgagggttt cccccatatc gaattcaaaa ttattgatca 25321 tgtctacaat gagaagggct ttatctgctt tggacaatcg acagtctcct ttccgtttca 25381 gttatagtta atatgtagcc tttttaggca atgaaaaaac tttgaaaaga gagcttatcc 25441 ttatgacaca agatgaactt tatatgaaag aagcaattaa agaagcgaaa aaggctgaag 25501 agaaaggtga agtgccaata ggtgcggtgc ttgtcattaa tggtgaaatt atagcgcgtg 25561 cgcataattt aagagagact gaacagcgat ctattgccca tgcagaaatg cttgtaattg 25621 atgaagcgtg taaggcactc ggaacatggc ggctggaagg tgcgactctt tatgtgacgc 25681 ttgagccttg tccaatgtgt gctggtgcag tcgtactttc tcgagtggaa aaagtggttt 25741 ttggcgcatt tgatccgaaa ggcggctgtt caggcacgct aatgaacctt cttcaggagg 25801 aacgctttaa tcatcaggct gaagtggtga gcggtgtgct tgaggaagaa tgcggcggaa 25861 tgctcagtgc gtttttcaga gaactaagaa aaaagaagaa agccgccagg aaaaacttgt 25921 ctgaatagta cggttgcaat ttttagggga aacagatata cttaagtgtg catcgtaata 25981 gatgcaacat aaaatttgat atttattttg ccgtgctaag cggggaggta gcggtgccct 26041 gtacctgcaa tccgctctag cagggccgaa tcccttctcg aggttcgttt actttaaggc 26101 ctgccttaag taagtggtgt tgacgtttgg gtcctgcgca atgggaattc atgaaccatg 26161 tcaggtccgg aaggaagcag cattaagtga aacctctcat gtgccgcagg gttgcctggg 26221 ccgagctaac tgcttaagta acgcttaggg tagcgaatcg acagaaggtg cacggtaaat 26281 caatcatcaa attttcagac tcacctaata ttaggtgagt tttttgttat gtaaaaagag 26341 cttttggaat cgaaacaagg ttcatgtata atgggaatga tgaataacgg aggagggcaa 26401 acccgtgagt taccaagctt tatatcgagt attcaggcct cagcgctttg aagatgtggt 26461 cggacaagaa cacattacaa aaacgctgca aaatgccctt ttgcaaaaaa agttttctca 26521 cgcctatctg ttttccgggc ctagaggaac cggaaaaacc agtgcagcca aaatatttgc 26581 taaggctgtc aactgtgaac atgctcctgt tgatgagcca tgcaacgaat gtgcggcctg 26641 taaagggata acaaacgggt caatatccga tgtcatagaa attgacgccg cttctaataa 26701 cggtgttgat gagattcgtg acattcgcga taaagtgaag tttgccccat cggccgtcac 26761 atataaggta tatatcatag atgaggtgca tatgctttct atcggcgctt ttaatgcatt 26821 actaaaaaca ttagaagagc cgcctgagca ttgtattttc atattagcaa caactgaacc 26881 gcacaaaatt cctttaacca ttatctctag atgtcagcgt tttgacttta aacgaattac 26941 ctcccaagcg attgtaggcc gcatgaataa aattgttgat gctgaacagc tgcaagtgga 27001 ggaaggatcg ctggaaatca tcgcgagtgc tgcagacgga gggatgaggg atgccctgag 27061 ccttcttgat caggccatat cattcagcgg cgatatcctg aaagtcgaag atgcgctttt 27121 aattacgggt gctgtttctc aattatatat cgggaagctt gcaaaatccc tgcatgataa 27181 aaacgtttct gacgcactgg aaacattaaa tgaattgctt cagcaaggaa aagatccagc 27241 taagctgata gaagatatga ttttctattt cagggacatg ctgctgtaca aaacagcccc 27301 tggcttagag ggagtgcttg agaaagtaaa agtcgatgaa acgttccggg aactaagtga 27361 acaaattccg gctcaggccc tatatgaaat gattgatatt ctgaacaaga gccatcagga 27421 aatgaaatgg acaaatcatc cgcgtatctt tttcgaagtg gccgttgtga agatttgcca 27481 aacctcacat caatctgctg ctgatctccc ggaagtggat atgctgatga aaaaaatcca 27541 gcagctcgaa caggaagtag agcggctcaa aacaacgggc ataaaagcag ctgcggaaag 27601 cccgaaaaaa gaagcgccgc gtgtgccaaa gggcgggaaa tccaattaca aagcgccagt 27661 aggcagaatt catgagattt tgaaggaagc cacaagaccg gatcttgatc tgctcagaaa 27721 cagttggggc aagcttcttg ctcatctcaa acagcaaaac aaagtatcac atgccgcttt 27781 gctgaatgac agtgaacctg tggctgccgg atcggcggca tttgttctga aattcaaata 27841 tgaaattcat tgtaaaatgg tcgctgagga taacaacgga gtccggacta atcttgagca 27901 gattttagaa tcgatgctcg gaaaaagaat ggatttgatt ggcgttccag aagcacaatg 27961 gggtaaaata agagaagaat ttttagaaga tcatcagcag gaaaatgaag gatcaaatga 28021 accggctgaa gaagacccgc ttattgccga agcgaaaaag cttgttggag cggatttaat 28081 tgaaataaaa gactaacaaa atgaaagaga gtgaatgcta tgcgtggcgg aatgggtaat 28141 atgcaaaaaa tgatgaaaca aatgcaaaaa atgcaaaagg acatggcgaa ggctcaagaa 28201 gagcttgcag aaaaggttgt tgaaggaact gcaggcggcg gtatggtaac agtaaaagca 28261 aacggccaaa aagaaatcct ggatgttatc atcaaagaag aagtcgttga tcctgaagat 28321 attgatatgc ttcaagattt agtgcttgct gcaacgaatg aagctttgaa aaaagttgac 28381 gaaatcacaa acgaaacaat gggtcaattt acaaagggaa tgaacatgcc aggtttattc 28441 tagggggata aaagaacatg caatatcctg aaccaatatc aaagctgatt gacagcttta 28501 tgaaattgcc agggatcgga ccgaaaacag cggttcgtct ggcttttttt gttctaggta 28561 tgaaagaaga tgtagtatta gattttgcga aagcattagt aaatgcgaaa cgcaacctga 28621 catattgttc agtttgcggg catattacag atcaggaccc ttgctatata tgtgaagata 28681 cgcgcaggga taagtctgtt atctgtgttg tgcaagaccc taaagacgtt atcgctatgg 28741 agaaaatgaa ggaatacaac ggacagtatc acgttcttca cggcgctatt tctccaatgg 28801 acggcatcgg accggaggat attaaaatac cagaattgtt aaaacgatta caggatgatc 28861 aagtgacaga agtgatcctc gcgacaaacc ctaatataga aggggaagca acagcgatgt 28921 atatatcaag gctcctcaag ccgtctggta ttaagctctc ccgtattgcc cacggactgc 28981 ccgtcggcgg tgatttggaa tatgctgatg aggtcactct ttctaaagca cttgaaggaa 29041 gacgtgaatt gtaaggagga aaaagcgatc catgggtttt cttcgcaaga aaacattaag 29101 aagagagttt gatgaaaaac taaccgagca gctttttaag caaaaggaag agtggaacag 29161 gcaaaaaaag ctggttgaaa aaagcttaga accgtctgct gaagtgttat acgaactgaa 29221 agtagctgaa gcgaagtatt ttttttactt aagggaagcg aagcagcgaa atttaaaaat 29281 cagccggtgg aagtaagtgg tctaaactcc tggatcttct cataagcttg tactagaaca 29341 agcgaaggag atgagaagat tcatggagcc tatttttatt attgggatta ttttaggact 29401 ggttattctt ctttttttat caggttcagc agcgaagcct ttaaagtgga ttggcatcac 29461 agctgttaaa tttgtggcag gtgctttgct gctggtttgt gtaaatatgt ttggcggcag 29521 tcttggcatt catgtgccga ttaatctggt tacaacagct atcagcggaa ttttaggaat 29581 acccggaata gctgcgttag tcgtcattaa gcaatttatc atttaattga tattatgtat 29641 tgacttagac aactgaaggt gttattctaa tatacgtcgc tgatgacgaa cagctttttt 29701 gaaaagaaaa tgctaaaaag ttgttgacag tagcggcggt aaatgttatg ataataaagt 29761 cgcttaaacg agcggtaaac aaagttcttt gaaaactaaa caagacaaaa cgtacctgtt 29821 aattcatttt tataaatcgc acagcaatgt gcgtagtcag tcaaactact ttatcggaga 29881 gtttgatcct ggctcaggac gaacgctggc ggcgtgccta atacatgcaa gtcgagcgga 29941 cagatgggag cttgctccct gatgttagcg gcggacgggt gagtaacacg tgggtaacct 30001 gcctgtaaga ctgggataac tccgggaaac cggggctaat accggatggt tgtttgaacc 30061 gcatggttca aacataaaag gtggcttcgg ctaccactta cagatggacc cgcggcgcat 30121 tagctagttg gtgaggtaac ggctcaccaa ggcgacgatg cgtagccgac ctgagagggt 30181 gatcggccac actgggactg agacacggcc cagactccta cgggaggcag cagtagggaa 30241 tcttccgcaa tggacgaaag tctgacggag caacgccgcg tgagtgatga aggttttcgg 30301 atcgtaaagc tctgttgtta gggaagaaca agtaccgttc gaatagggcg gtaccttgac 30361 ggtacctaac cagaaagcca cggctaacta cgtgccagca gccgcggtaa tacgtaggtg 30421 gcaagcgttg tccggaatta ttgggcgtaa agggctcgca ggcggtttct taagtctgat 30481 gtgaaagccc ccggctcaac cggggagggt cattggaaac tggggaactt gagtgcagaa 30541 gaggagagtg gaattccacg tgtagcggtg aaatgcgtag agatgtggag gaacaccagt 30601 ggcgaaggcg actctctggt ctgtaactga cgctgaggag cgaaagcgtg gggagcgaac 30661 aggattagat accctggtag tccacgccgt aaacgatgag tgctaagtgt tagggggttt 30721 ccgcccctta gtgctgcagc taacgcatta agcactccgc ctggggagta cggtcgcaag 30781 actgaaactc aaaggaattg acgggggccc gcacaagcgg tggagcatgt ggtttaattc 30841 gaagcaacgc gaagaacctt accaggtctt gacatcctct gacaatccta gagataggac 30901 gtccccttcg ggggcagagt gacaggtggt gcatggttgt cgtcagctcg tgtcgtgaga 30961 tgttgggtta agtcccgcaa cgagcgcaac ccttgatctt agttgccagc attcagttgg 31021 gcactctaag gtgactgccg gtgacaaacc ggaggaaggt ggggatgacg tcaaatcatc 31081 atgcccctta tgacctgggc tacacacgtg ctacaatgga cagaacaaag ggcagcgaaa 31141 ccgcgaggtt aagccaatcc cacaaatctg ttctcagttc ggatcgcagt ctgcaactcg 31201 actgcgtgaa gctggaatcg ctagtaatcg cggatcagca tgccgcggtg aatacgttcc 31261 cgggccttgt acacaccgcc cgtcacacca cgagagtttg taacacccga agtcggtgag 31321 gtaacctttt aggagccagc cgccgaaggt gggacagatg attggggtga agtcgtaaca 31381 aggtagccgt atcggaaggt gcggctggat cacctccttt ctaaggatat tttacggaat 31441 ataagacctt gggtcttata aacagaacgt tccctgtctt gtttagtttt gaaggaactt 31501 tgttccttga ataagttaag atgggcctgt agctcagctg gttagagcgc acgcctgata 31561 agcgtgaggt cggtggttcg agtccactca ggcccaccat cttatataac ggggccttag 31621 ctcagctggg agagcgcctg ctttgcacgc aggaggtcag cggttcgatc ccgctaggct 31681 ccaccaacgt gttctttgaa aactagataa cagtagacat cacattcaat tagtaacaca 31741 agatatcaca tagtgattct ttttaacggt taagttagaa agggcgcacg gtggatgcct 31801 tggcactagg agccgatgaa ggacgggacg aacaccgata tgcttcgggg agctgtaagc 31861 aagctttgat ccggagattt ccgaatgggg aaacccacca ctcgtaatgg agtggtatcc 31921 atatctgaat tcataggata tgagaaggca gacccgggga actgaaacat ctaagtaccc 31981 ggaggaagag aaagcaaatg cgattccctg agtagcggcg agcgaaacgg gattagccca 32041 aaccaagagg cttgcctctt ggggttgtag gacactctgt acggagttac aaaggaacga 32101 ggtagatgaa gaggtctgga aaggcccgcc ataggaggta acagccctgt agtcaaaact 32161 tcgttctctc ctgagtggat cctgagtacg gcggaacacg tgaaattccg tcggaatccg 32221 ggaggaccat ctcccaaggc taaatactcc ctagtgaccg atagtgaacc agtaccgtga 32281 gggaaaggtg aaaagcaccc cggaagggga gtgaaagaga tcctgaaacc gtgtgcctac 32341 aagtagtcag agcccgttaa cgggtgatgg cgtgcctttt gtagaatgaa ccggcgagtt 32401 acgatcccgt gcaaggttaa gcagaagatg cggagccgca gcgaaagcga gtctgaatag 32461 ggcgcatgag tacgtggtcg tagacccgaa accaggtgat ctacccatgt ccagggtgaa 32521 gttcaggtaa cactgaatgg aggcccgaac ccacgcacgt tgaaaagtgc ggggatgagg 32581 tgtgggtagg ggtgaaatgc caatcgaacc tggagatagc tggttctctc cgaaatagct 32641 ttagggctag cctcaaggta agagtcttgg aggtagagca ctgattggac taggggcccc 32701 taccgggtta ccgaattcag tcaaactccg aatgccaatg acttatcctt gggagtcaga 32761 ctgcgagtga taagatccgt agtcgaaagg gaaacagccc agaccgccag ctaaggtccc 32821 aaagtatacg ttaagtggaa aaggatgtgg agttgcttag acaaccagga tgttggctta 32881 gaagcagcca ccatttaaag agtgcgtaat agctcactgg tcgagtgact ctgcgccgaa 32941 aatgtaccgg ggctaaacgt atcaccgaag ctgcggactg ttcttcgaac agtggtagga 33001 gagcgttcta agggctgtga agccagaccg gaaggactgg tggagcgctt agaagtgaga 33061 atgccggtat gagtagcgaa agaggggtga gaatcccctc caccgaatgc ctaaggtttc 33121 ctgaggaagg ctcgtccgct cagggttagt cgggacctaa gccgaggccg aaaggcgtag 33181 gcgatggaca acaggttgat attcctgtac cacctcctca ccatttgagc aatgggggga 33241 cgcaggagga tagggtaagc gcggtattgg atatccgcgt ccaagcagtt aggctgggaa 33301 ataggcaaat ccgtttccca taaggctgag ctgtgatggc gagcgaaata tagtagcgaa 33361 gttcctgatt ccacactgcc aagaaaagcc tctagcgagg tgagaggtgc ccgtaccgca 33421 aaccgacaca ggtaggcgag gagagaatcc taaggtgatc gagagaactc tcgttaagga 33481 actcggcaaa atgaccccgt aacttcggga gaaggggtgc tctgttaggg tgcaagcccg 33541 agagagccgc agtgaatagg cccaggcgac tgtttagcaa aaacacaggt ctctgcgaag 33601 ccgtaaggcg aagtataggg gctgacgcct gcccggtgct ggaaggttaa gaggagcgct 33661 tagcgtaagc gaaggtgcga attgaagccc cagtaaacgg cggccgtaac tataacggtc 33721 ctaaggtagc gaaattcctt gtcgggtaag ttccgacccg cacgaaaggc gcaacgatct 33781 gggcactgtc tcaacgagag actcggtgaa attatagtac ctgtgaagat gcaggttacc 33841 cgcgacagga cggaaagacc ccgtggagct ttactgcagc ctgatattga atgttggtac 33901 agcttgtaca ggataggtag gagccttgga aaccggagcg ccagcttcgg tggaggcatc 33961 ggtgggatac taccctggct gtattgacct tctaacccgc cgcccttatc gggcggggag 34021 acagtgtcag gtgggcagtt tgactggggc ggtcgcctcc taaaaggtaa cggaggcgcc 34081 caaaggttcc ctcagaatgg ttggaaatca ttcgcagagt gtaaaggcac aagggagctt 34141 gactgcgaga cctacaagtc gagcagggac gaaagtcggg cttagtgatc cggtggttcc 34201 gcatggaagg gccatcgctc aacggataaa agctaccccg gggataacag gcttatctcc 34261 cccaagagtc cacatcgacg gggaggtttg gcacctcgat gtcggctcat cgcatcctgg 34321 ggctgtagtc agtcccaagg gttgggctgt tcgcccatta aagcggtacg cgagctgggt 34381 tcagaacgtc gtgagacagt tcggtcccta tccgtcgcgg gcgcaggaaa tttgagagga 34441 gctgtcctta gtacgagagg accgggatgg acgcaccgct ggtgtaccag ttgttctgcc 34501 aagggcatcg ctgggtagct atgtgcggac gggataagtg ctgaaagcat ctaagcatga 34561 agcccccctc aagatgagat ttcccattcc gcaaggaagt aagatccctg aaagatgatc 34621 aggttgatag gtctgaggtg gaagtgtggc gacacatgga gctgacagat actaatcgat 34681 cgaggactta accacatttt gaatgatgtc acacctgtta tctagttttg agagaacacc 34741 tctctaaagg cggaaggtaa ggaaactccg ctaagggctc tcacatcctg tgagaaacgc 34801 ccagtacctt catcctgaag gcatttgttt ggtggcgata gcgaagaggt cacacccgtt 34861 cccataccga acacggaagt taagctcttc agcgccgatg gtagtcgggg gtttccccct 34921 gtgagagtag gacgccgcca agcaagctta aacccagctt aatgagctgg gttttttgtt 34981 tactcaagat cgagaaaatc aaacaaatac aaacaccgag ggcttatata gcccatatac 35041 tgatttaaag tttcaaaaag gtctaaatag tgtatacaat atccgtttta aggggaggct 35101 aactgtacgg aggtggagaa gatggacgaa acagttaaac ttaatcatac atgtgtgatt 35161 tgtgatcaag agaagaatag aggcattcat ctttatacga aattcatatg cttagattgt 35221 gagagaaaag taatttctac atcaacttct gatcctgact atgcgtttta cgtaaaaaaa 35281 ctaaagagca ttcatacacc gccattatat tcatagacct gaaaaggtct ttttttgtac 35341 tcttaataat aaaaagaaga tgaaacttgt ttaaggattg aacgtagtag ataataatat 35401 taaaactgag tatagacaca ggagtcgatt atctcatgca gagatttttt cactttttgg 35461 tgtggagttt aactagcagt gcgacttttg ttttcattgg aatattgagc ttttttggtt 35521 taaaccagtc gattttttta tctattgttt atgggcttgc ttctggagca gccgtatata 35581 tagctggcat ctggaatgca agacggttat ttcttaaaaa gcatgaattg acaggaagag 35641 agtatgctta cattaagaaa aacttagagg aagcaaggca gaaaatggtc cgtcttagga 35701 aagccttgtt tcaggctaaa agcattcaaa tgtttaagca aaatgcagaa atgctaagga 35761 ttgtgagaag gatttatctc ctcaccaaaa aagagccaaa gcggttttat caggcagaac 35821 gattttttta tcaaactctc gattcggttg ttgaattgac agagaagtat gcttttctat 35881 catctcaccc aaaaaaaagc aaagaactgt cgatgtcgtt aagtgagaca cgcatcactc 35941 ttactgaatt gaccaagcgt ttagaggaag atttaactca agcaatgggt gatgaaattg 36001 acgagttgca gtttgaatta gacgcagcaa aacattcatt aaagaaataa gggaagaggg 36061 taagagcgat gaaccgagac caaagcgacc ttcatataga tgaattattg gcagatcctt 36121 ttggtggtaa catagagata ccaggttcgg aggctgtaaa agcagagaaa gagcaagtac 36181 ggcttgttga tgttcttcct gaggaaaaca aggaaaaagc aattcagctt gctggacaga 36241 ttgatcataa aaatatgcaa agcattgtct tatacggttc acaagctcaa tctaaactgc 36301 tgaacttttc tcatgatatg attaatcatg ttcaaaagaa ggatgtcggg gagattggcg 36361 aaatacttgg agagctgatg aaaaagctgg agcaagtaaa tcctgatgat ctccaatcta 36421 agaaaaaggg ttttttggca cgcatgtttg gaagagtatc aagttctctt caagaggtgc 36481 tgtctaaata ccaaaagacc agtgtgcaga tagacagaat cagcttgaag ctggagcact 36541 ctaaaaatgc tttaatcagt gacaacaagc tgttagagca gttatatgaa aaaaataaag 36601 aatatttcgc agcgctgaat gtttatattg ctgcaggaga actgaagctg gaggaattaa 36661 aaacaaaaac gattcctgaa ctgaagcaac aggctgaatc gagtgatcat aaccaaatgg 36721 ccgttcaaga ggtgaatgat ttaattcaat ttgctgaccg gttagataaa agggtgcatg 36781 atttgctgct gagcaggcaa attacaatcc aaagtgcacc gcaaatcagg ctgattcaaa 36841 atacaaacca agcgttagct gaaaagattc agtcatccat tgtgacagcg attccgttat 36901 ggaaaaatca agttgccatt gcactgacgc ttttaaggca gcgcaatgca gtggatgcac 36961 agcagaaagt atctgataca accaatgagc ttttgctgaa aaatgcggag cttttaaaaa 37021 ccaatacaat tgaaactgca cgggcaaatg aaagaggcct tgttgatata gataccttga 37081 agaaggtgca ggaaagctta ataagcacgc ttgaagaaac actgactata caagaagaag 37141 gacgaatcaa acgccgtcag gcagaagaag agctcatgat gatggaaggc gacctgaagc 37201 aaaagctgat tacaataaag gaaagatgat taccagtaag tctggcttta agttctgtca 37261 gaggcacgat ataataaggt gtaagaagac acattcaaag gattgttttc atgaacacac 37321 ctttatataa agcattaatt caacatgcga gaagaaattc tcattcattt catgttccgg 37381 gacatcacaa tggagatgtc ttttttgatg acgctaagtc aatattcgat ccgcttctca 37441 ccattgatgt aactgaactg gcaggactgg atgatctcca tcatccttct ggggtgatta 37501 aggaagctca ggagcttgcc agtcaattat atggatcggc ggaaagtttt tttctggtaa 37561 atggtacgac tgtcggaaac ttagcgatga ttttatctgt ttgtgaacct ggtgatacaa 37621 ttctggttca aagaaactgt cataaatctg tatttcatgc tgttgatttg tccggtgctg 37681 agccggttta tcttgcacct gacgttgatt cagcgatgca tgtgcctacg catgttccgc 37741 ttggaacaat taaagaggcc ctggaagcat atccagatgc gaaaggcttg gtactgacca 37801 atccgacata ttacggacat agtgctgatt tgactgagat cattactgaa gcccatcatt 37861 acgggattcc tgttttggtc gatgaagcgc atggcgcaca ttttatttta ggtgagcctt 37921 ttccggtctc agctttaaaa atgggggcag atattgttgt tcagtcggcc cacaaaacgt 37981 tgccagccat gacgatgggt tcttatttgc atctcaacag cagctgcagg attaacaggg 38041 atcgggtggc agagtattta aaccgattac aaagcagcag cccgtcttat ccgattatgg 38101 cttcgttaga tattgcccgc gcttatgtac agcatattat agaagaacaa aagctttctg 38161 acattctgca gcggatagaa acacttaaac aaacgtttga ttcacttaca aatgcagaag 38221 ctgttaaccc tgctaatcca ctgatcatca cggatccgct aaagctcaca attcgttcaa 38281 aacgcgggca ttctggctat acgctgcaaa gcattttaga gcgtgccaac atattcactg 38341 agcttgctga tgaaaatcaa gttctgctcg ttctcccatt gggaggaaaa cggagaataa 38401 acgctgaaat cattagaagc atcgatgaag agattgagaa aacgcctccg gatcagacgt 38461 ttgtttctgc agaatggggt gtgcagcctg ttactgtctt gccttatcca aaaaaggtct 38521 tacattcgtt taagaaagaa tatgtgagct ttgaggaagc agctggccgg cttaatgcag 38581 aagatatcat cccttatcct ccgggtatcc cgatgattat ggcgggagaa agaataacaa 38641 aagaaagtgt gcaaaagctc agccgcttga tcagcatgaa aacgcatgtt caagggaata 38701 tgaaaatcaa agagaaacaa ctacttgttt atatagaaga ggagaaatca tgagcggttt 38761 atttattaca ttcgaaggtc ctgaaggtgc agggaaaacg actgttctgc aggagatcaa 38821 aaacatactg acagcagaag gccttcaggt tatggcaact cgagagccag gcggaataga 38881 tattgcagaa caaattagag aggttattct gaatgagaac aatatattaa tggacccaaa 38941 aacagaagct ctcttatatg cggctgcaag acgccagcat ttagttgaaa aagtaaaacc 39001 tgctttagaa caggggttta tcgttctttg cgacagattc atagacagtt ctcttgcgta 39061 tcaaggatat gcaagagggc ttggaattga tgaggttctg tccattaatg aatttgccat 39121 tggagatatg atgccccatg taacggttta tttttcaatt gatccggaag aaggactgaa 39181 gcgtatttac gcaaacggct cacgggagaa aaacaggctc gatttagaaa aactggactt 39241 tcatacaaaa gtacaagaag gttatcaaga gctgatgaag cgatttccgg aaagatttca 39301 ttcagttgat gccgggcaat ccaaagacct cgtcgttcag gatgttctaa aggtgatcga 39361 tgaagcgttg aaaaaaattc aattgtgacc tgtttcccaa tagttgatat aataatgtaa 39421 acgagatcac gttgtttcca atctaaagga ggccttcaca gatgaaattg atagtggcag 39481 ttgtacaaga tcaggacagc aacagacttt tgaaaacctt aacggatcac aacttcagag 39541 tcacaaagct tgcaacgaca ggaggatttc ttaaatcagg caatacaacg tttatgatcg 39601 gtgtcgagga tatacgcgtc aataaagcgt tgagtctcat taaagaaaac gggcagaaac 39661 gtgatcagat gattgcccct gtatctccaa tgggtggaaa tgctgattcc tatgtccctt 39721 atccagtcga agttgaagtt ggcggagcga cagtatttgt ccttccagtc gatgaatttc 39781 atcaatttta aggatctgaa actgtgaaaa ttaataaaga tatacgtaca tttatagata 39841 ataagcagat tccctctgtg aaaacatctg agatcacagc atcgtttaaa acatcaatgg 39901 aaaaccaaag cagcaaaatg aagcttgatc agcttaccag gctgttatct gatatagaag 39961 catttggaaa aaggctaacg aaatctcgga attttaaaga cttagcgaga tttaaaggac 40021 ttgtgaaacg ttttgtcaaa gaagctgtgg acagcggtct ttcacatgaa acatcgaaaa 40081 gctttgacct ttacgggaac agcagaacgc tgggacttgt gaaagaaata gatgacaaat 40141 tgatacagct tacggaagag atgatggatc aggaaaaacc ggcaattgat ttgctggagc 40201 gtattggcga aataaaaggt ttattaatta acctttacac atagagagtg atacaatggc 40261 aatatcctgg aaggaaatga acgagcttca gcccagagtg atgaagcttt tatataatag 40321 tattgagaag gacagactat cacacgctta tttgtttgag gggaaaaaag gaacaggcaa 40381 gcttgatgcc gcgctgcttc ttgcaaaaag cttcttttgt ctggagggtg gcgcggagcc 40441 ttgtgagagc tgccgaaact gtaaacggat agagtcaggg aaccatcctg atctccatct 40501 tgttcagcct gatggcttat caatcaaaaa ggcgcaaatt caagcgctcc aagaagagtt 40561 ttctaagaca ggacttgaat cgcataaaaa gctgtatatt atttcgcacg cagatcaaat 40621 gacagcaaat gcggcgaaca gcctgctgaa atttttagaa gaaccgaaca aagacacaat 40681 ggccgtcctc atcactgagc agccccaaag gttattggat accatcattt caagatgcca 40741 aacccttcct tttcagcctt tgcagccgaa agcaattgaa gacagactga tcgaacagga 40801 cgtctcgcct catatggcaa ggcttctggc caacatgact aataatgtag cagaagcagt 40861 cgaattaagt cgaaatgatg agtttgcaga gtctagagcg aaagtgataa aattgtatga 40921 agtcctacac cagcggaaag gacatgcttt tttctttatt caagatcaat ggatgccctt 40981 tttcaaagaa aaaacccatc aagaaatggg tcttgatatg ctcttattga tatatcgtga 41041 tgtgttgtcc atccaaatag gaaatgaaga taaattgatt tatcaagact tattccaatc 41101 aataaaacag catgcgctac aatcaacaca acaaagcgtt acgaatcaga tacttgctgt 41161 tttagaagca aagaaacggc ttcattccaa tgtgaatgta caaggattaa tggagcactt 41221 ggtgttaatg ttgcaggagg gataagcttg tacaatgtaa ttggtgtccg ctttaagaaa 41281 gcgggtaaaa tatattattt tgatccgaat ggatttcata tagaacatga cagctgcgta 41341 attgtagaaa ctgtcagagg cgttgagtac ggccaggtcg taattgcaaa taaacaggtg 41401 gatgagcatg atgtggtgct tccccttcga aaagtgatac gtgtggcaga cgatcgcgat 41461 cttctcattg tagaagaaaa taaacaggaa gcactatcag catttgatat ctgccaaaag 41521 aaagtgattg agcatggctt ggatatgaag ctggtcgatg ttgaattcac gtttgatcgc 41581 aataaagtca ttttttactt cactgctgac ggccgagtcg actttagaga gcttgtaaag 41641 gatttggctt ctatctttaa gacaagaatt gagctgcgcc aaatcggagt gagggatgag 41701 gcaaaaatgc tcggaggaat cggtccttgc ggaagaatgc tttgctgttc aacgtttctt 41761 ggagattttg aacccgtttc cattaaaatg gccaaggatc agaacttgtc tttaaatcct 41821 acgaagattt cgggtctttg cggacgattg atgtgctgtc taaaatatga gaacgatgag 41881 tatgagacgg caaaagaaca gcttccggat ataggagaaa tgattacgac agcaaacggt 41941 cccgcgaagg tcgtcggact aaatattctg gaacgggtgc ttcaggtgga actgataaac 42001 cgtgaaaaag tgatagaata tacttgggaa gagctcttgg aagagggcgt cgtatccgca 42061 caaaccacag attaacgagg tgtggaacct tggataaaaa agagttattt gatacagtca 42121 ttaacttaga agaacaaatt ggctcactgt accggcagct gggggatttg aagcagcata 42181 tcggtgagat gattgaggaa aatcatcatt tacagcttga aaacaagcat ttgcgcaaac 42241 ggctggacga tacgacgcag cagattgaaa agttcaaagc tgataaaaaa gaatcaaaaa 42301 cacagaagac agagcaaact gatatagggg aaggatatga taatctggca cgtctgtatc 42361 aagaaggatt tcatatctgc aatgtccact atggaagtgt tcgaaaagag gattgtcttt 42421 tctgtctgtc attcttaaat aaaaaatagg gaaaaggctt ccgcataaga cgggagcctt 42481 tttcaaaggt actgaaagga taagaagatg gtttcattac atgatgatga aagattagat 42541 tatttgctgg cagaggacat gaaaatcata caaagcccaa cagtgtttgc tttttcgttg 42601 gacgctgtgc ttctgtccaa atttgcgtac gttccgattc aaaaagggaa aattgttgat 42661 ttatgcaccg gcaatggtat tgtgccgctg ctgctcagta caagatcaaa agcagacatt 42721 ctgggagtcg aaattcaaga aagactgcat gatatggctg ttcgcagcgt ggagtataat 42781 aagttggacg atcagatcca gatcatacat gatgacctga aaaacatgcc ggagaaactt 42841 ggacataatc gatatgatgt tgtcacctgc aatccgccgt attttaaaac gccgaaacaa 42901 actgaacaaa acatgaacga gcatctccga atcgcaagac atgaaatcca ctgcacgctg 42961 gaggatgtca tttcagtcag cagcaagctg ctcaagcaag ggggaaaagc agctcttgtt 43021 caccggccgg gaaggcttct ggagattttt gaactgatga aggcttatca aatcgagccg 43081 aaacgtgtac aatttgtcta tccgaagcaa gggaaagaag ccaataccat tttggttgaa 43141 ggtatcaaag gcgggcgccc ggatttgaaa attcttcctc ccttattcgt atatgatgaa 43201 caaaatgaat atacaaaaga aatcaggacc attttatatg gagacaaata accatttctt 43261 ctacgtcgtg aaatgtaagg acaatagctg gtatgccggg tataccaacg atctgcataa 43321 acgagtgaaa acgcacaatg atggaaaggg cgcaaagtac acaaaagtaa gacgtccggt 43381 tgaattaatt tttgccgaga gcttttcaac aaagcgggaa gctatgcagg cggaatatta 43441 tttcaaaaaa ctaactcgga agaaaaaaga gctttatata gaagaaaagc ggaacagcaa 43501 ggaggctgta tatgttaagg cgccaaatga gctttaatgg aaagtcggac atggggattc 43561 tttacttggt cccaacccca atcggaaatt tagaggatat gacattccgg gcgatcgaca 43621 cgctgaaatc agtggatgcg attgctgcgg aagatacgag gcaaacgaaa aagctttgtc 43681 atgtatatga aattgaaaca ccgctcgtca gctatcacga acacaataaa gaaagcagtg 43741 ggcacaaaat tattgaatgg ctgaaatcgg gaaaaaacat tgctcttgtc agtgatgccg 43801 gtctgccgac gatttctgat cccggagcgg aaattgtaaa ggattttacg gatataggcg 43861 gttatgttgt tccgttgccg ggagcaaatg ctgcattaac agctcttatt gcttcaggta 43921 ttgtaccgca gccttttttc ttttacggtt ttctcaacag acagaaaaaa gaaaagaaga 43981 aggagcttga agcccttaaa aaacggcagg aaacgatcat tttttatgaa gcgccccaca 44041 gattgaagga aaccttgtca gcgatggcag agatattagg agatcgggaa attgctgtaa 44101 cacgtgaact cactaagaaa tatgaagagt ttatccgagg aaccatatct gaggtcattg 44161 gatgggcaaa cgaggatcag atacgcggcg agttttgtct tgtcgtagaa ggaagtaata 44221 atgaagaggt agatgaggaa gaacaatggt gggaaaccct cactgcgaaa gaacatgtcg 44281 agcattacat ttcgaaaggc gctacgtcta aagaagctat taaaaaagca gcagtcgatc 44341 gcaatgtacc aaagcgtgaa gtgtacgatg cttaccatat taagcaataa aaaaacgttc 44401 ttgtgtcata acaagaacgt tttttgtaca agaaatgatt atttaaggtt ttgaagctgg 44461 ttttggattt cgctgatgat ttgctcagcg ccttctttac taagaaccaa tttaccgcct 44521 gcaagtttaa ggttatcatc agaaacttca ccagttactt ggcaagtcat gtttggttta 44581 tattttttaa ggatgatttt ttcatcatca acatagattt caagagcatc tttttctgcg 44641 attccaagag tacgacgcag ttcgatagga ataactacac gtcctaattc atcaacttta 44701 cgtacaatac cagtagattt cataaacatt ctcctcccaa gagatactta tttgtttaaa 44761 ttatattttt cttcgtcatt attcgacaaa atccttacct tcatagcata acaaggtttc 44821 caataatcgt caatcatttt gtttactatt gattgtaaga attagttctt atagtcagta 44881 atgtcttgga aactaccgaa ataacagcat tttataaata tttaataaag ctattatcct 44941 actaaaaatc cttttaaatc aagactttcg aaccaaagtt ttttatttca tttgattata 45001 tacgacaaaa ttcgacacga acagactttt tttattttca ttaaagattt ttaattttaa 45061 ttattctttt tcagggcgta tgtatatatt cttgatctta aaggctaaga tggtatcata 45121 gataaaggat aaatataaat aatattcata tatgatttgc acttatcgcc gctctcgtcc 45181 tttgggcggg agctttttga cattctgatt aggaggtttc aagatgccgc aagaaaacaa 45241 tacattttac attacaacac cgatttatta tccgagcgga aaattacata tcggccatgc 45301 atatacgaca gtcgcaggag atgcaatggc acgttacaaa agattaaaag ggttcgatgt 45361 tcgctattta acgggaacgg acgagcatgg acaaaagatc cagcaaaaag ctgaacagga 45421 aaacattaca cctcaggagt atgtggatcg cgcagcggca gatattcaaa aactgtggaa 45481 gcagcttgaa atctcaaacg acgactttat ccgcacgaca gaaaaacggc ataaagttgt 45541 cattgaaaaa gtgtttcaaa agcttcttga taacggggac atctatcttg atgagtatga 45601 aggctggtac agcatccctg atgaaacgtt ctacacggaa actcagctcg ttgatattga 45661 gcggaatgaa aagggagagg tcatcggcgg aaaaagccct gacagcggtc acccagttga 45721 attgatcaaa gaggaatctt atttcttccg catggggaaa tacgcggatc gtcttctgaa 45781 atactatgaa gaaaacccga cattcattca gccagaatca cgcaaaaacg aaatgattaa 45841 taactttatc aaacctggac ttgaggattt ggcagtatca cgtaccactt ttgattgggg 45901 cgtgaaggtg ccggaaaatc caaagcatgt tgtatatgtt tggattgacg cactatttaa 45961 ctatttaacg gcactcggtt atgatacaga aaatgatgag ctttatcaaa aatattggcc 46021 tgccgatgtt catttagtcg gtaaggagat tgtacgattc catactattt actggccaat 46081 tatgctgatg gcgctggatc ttccgctgcc aaagcaagta ttcgcgcatg gctggctttt 46141 gatgaaagac ggaaaaatgt cgaaatcaaa aggaaacgtt gtagatccgg ttacattaat 46201 tgaacgctat ggtttagacg aacttcgcta ttacttgctt cgcgaagtgc cgttcggatc 46261 agacggtgtt ttcacgccgg aaggatttgt tgagcgaatc aactatgatt tagcgaatga 46321 tttaggaaat ctattgaatc gtactgttgc gatgattaat aagtattttg acggacaaat 46381 cggttcttac aaaggtgctg ttacggaatt tgaccatacg ctcacttctg ttgctgaaga 46441 aacagtgaaa gcttatgaga aagcaatgga aaatatggag ttctcggtag cactttcgac 46501 tttatggcag ctcatcagcc gcacaaacaa atacattgat gagacagctc catgggtgct 46561 tgcgaaagat ccggcaaaag aagaagaatt gcgatcagtt atgtatcatc tcgctgaatc 46621 attgcgtatt tcagcggtac tgcttcagcc attcttaaca aaaacacctg aaaaaatgtt 46681 cgagcagctg ggcattactg atgaatcttt aaaagcttgg gacagcatta cagctttcgg 46741 ccagctgaaa gatacaaaag tacaaaaagg cgagccattg ttccctcgtt tagaggcaga 46801 agaagaaatt gcttacatca aagggaaaat gcaaggttca gcaccagcga aagaagaaac 46861 aaaagaagaa gagcctcaag aggtcgatcg tttacctgaa attacgattg atcaatttat 46921 ggatgtagag cttcgcgtag ctgaggtcat tgaggcagag ccagtgaaaa aagcagaccg 46981 tttattgaag ctgcagcttg atcttggttt tgaaaagcgc caagtggtat ccggcattgc 47041 gaagcattat acgcctgaag agcttgttgg aaaaaaactc gtttgtgtaa caaatctaaa 47101 accggttaaa ctcagaggag agctttctca aggtatgatc cttgcaggag aagcagacgg 47161 cgttttaaag gtcgtatcta tcgatcagtc gttaccaaaa ggcacaagaa ttaaataatg 47221 ataaacaaaa ggtgtttcac gtgtaacaat tcgtcgaaca ccttttgtgt ttcgacaaga 47281 aaggagtttt tcacttatgt tgtttgacac tcacgcgcat ttaaatgcag aacaatatga 47341 tactgatctt gaagaggtta ttgaacgggc aaaagctgaa aaagttgaac gaattgtcgt 47401 agttggtttt gaccgtccga cgattacccg tgcgatggaa atgattgagg aatatgattt 47461 tatttatgca gccattggct ggcaccctgt tgacgctatt gacatgacag aggaagactt 47521 agcgtggatt aaagagcttt ctgctcatga gaaagtggta gcgatagggg aaatgggact 47581 ggattatcat tgggataaat cacctaaaga tattcaaaaa gaggtgttta gaaatcaaat 47641 cgccttagcg aaagaggtca atttgcctat tatcattcat aaccgtgatg caacggagga 47701 tgtcgtgacc attttgaaag aggaaggcgc agaagctgtg ggcggaatca tgcactgctt 47761 tacaggaagt gcggaagtgg caagagaatg catgaaaatg aatttttatt tatcatttgg 47821 gggaccggtg acatttaaaa atgcgaagaa accgaaggaa gtagtgaagg aaattcccaa 47881 tgaccggctg ctgattgaaa cggactgccc gtttctcaca ccgcaccctt tccgcgggaa 47941 aagaaatgag ccaagctatg tgaaatatgt ggcagaacaa atcgccgaat taaaagaaat 48001 gacctttgaa gagattgctt ccatcacgac tgaaaatgcg aaaagacttt tccgtataaa 48061 ctgacaaaaa acgctagcgg gttttgtaag agcttgtccc ttacagcgtt tttctataaa 48121 agttctacat gctttcttct cctcatagga taggtttgtc gacaagtctt tcttccgttt 48181 ctcagtgtat ttcaggataa tgaagaggac actgagcttt tgggagaaag agaagggagg 48241 gttgacagcc ttttagatac tctatataat ctctccgagg agaaggaggc gtttttcatc 48301 acacaaaaaa tgaaaaagct gttttccgta aagcttagca aaagcaaagt cattctggtt 48361 gctgcttgtt tgcttttggc aggaagcggg actgcgtacg cggctcatga gctgacgaaa 48421 caatcagtct cagtttctat caatggcaaa aagaaacata tacgcacaca tgcaaataca 48481 gtcggtgatc ttttggagac gcttgatata aagacaagag acgaagacaa gatcacacct 48541 gctaaacaga caaagataac agcagacatg gacgttgtgt atgaggctgc aaaacctgtg 48601 aagcttacaa taaacgggga agaaaagacg ttatggtcaa cagcaaaaac ggtcggtgca 48661 ttactggacg aacaagatgt tgatgtgaaa gaacaagatc aaattgatcc cgcaatagat 48721 acagatattt cgaaagacat gaagattaac atagagcccg catttcaggt tactgtgaat 48781 gatgcaggga aacaaaagaa gatctggacg acttcgacta cggtcgctga ctttttaaaa 48841 cagcaaaaga tgaacataaa agacgaagat aaaatcaagc ctgcgttaga tgcaaagctg 48901 acgaaaggaa aggctgatat tacaattact cgtatcgaaa aggtcaccga tgtagttgaa 48961 gagaagattg cgttcgatgt gaaaaagcaa gaagacgctt ctcttgaaaa agggaaagaa 49021 aaggtcgtcc aaaaaggaaa agaaggcaag ctaaaaaaac atttcgaagt cgttaaagaa 49081 aacggtaaag aagtgtccag agagcttgta aaagaagaaa cagctgaaca aagcaaagat 49141 aaagtgattg ctgtcggcac aaagcaaagc agtccaaaat ttgaaacggt cagtgcttca 49201 ggtgattcaa aaacagttgt gtcccgcagc aatgaatcaa caggcaaagt catgactgta 49261 tcatctacgg cttatacggc aagctgcagc ggttgttcag gacatacagc gacaggcgtc 49321 aatttaaaaa ataatccgaa tgccaaagtc atcgctgtgg atccaaatgt cattccgcta 49381 ggctccaaag tccacgtgga aggctatgga tatgccattg ctgcagatac cggttcagcg 49441 attaaaggga acaagataga cgtctttttc ccagagaaat catcggcgta ccgatgggga 49501 aataaaacag tcaaaattaa aatcttaaat tagtatatac ttatgtattc agagggtttt 49561 gcgccctctg tttttttcgt tataatagac aaagtgcatt ttctgcttat tagacgctcg 49621 atataagaaa aagtttcatg aatatacaaa agtttttatt ttgtcttgga ggaaataatg 49681 aaaattaaag agatcattgt ggtcgagggg cgtgacgata cggcccgcat caaattggct 49741 gttgatgcag acacaattga aacaaatggt tcagccatcg atgatcatgt gattgaccaa 49801 atccgtttgg cccagaagac gagaggcgtc attattttaa cggatccgga ctttccggga 49861 gagaagattc gcaaaaccat ctcagaggct gtacccggct gtaagcatgc atttttgcca 49921 aaacatcttg ccaaacctaa aaacaagcgg ggaattggtg tggagcatgc atcggttgaa 49981 agcattaggg catgtttaga aaatgtgcat gaggagatgg aagcgcagcc gagtgacatt 50041 tcagctgagg atttgattca tgccggacta ataggcgggc ctgcggccaa atgccgccgg 50101 gaacgactgg gtgatctgtt gaaaatcggc tatacaaatg gcaaacagct tcaaaaacgg 50161 ctgcaaatgt ttcaaattaa aaaaagtgat tttatgagtg cgctcgatac cgttatgcgg 50221 gaggaacaga atgaataaag atattgcgac accgattaga acgaaagaga tactgaagaa 50281 atacggtttt tcttttaaaa agagcttagg acagaatttc ttaattgata cgaacatttt 50341 aaacagaatt gttgatcacg cggaagtgac ggagaaaaca ggtgtcattg aaatcggccc 50401 gggaatcggg gctttaaccg aacagcttgc caagcgggcg aaaaaggtcg tggcatttga 50461 gattgaccag cgattattgc cgattctgaa ggatacactg tcaccttacg aaaatgtcac 50521 tgtcattcat caggacgtgt taaaggctga tgtcaaatca gtcattgaag aacaatttca 50581 agattgtgat gagatcatgg tagttgccaa ccttccttat tacgtaacaa caccgattat 50641 catgaaactg cttgaagaac atcttccgct gaaagggatt gtggttatgc tgcaaaaaga 50701 agtggctgag cgcatggcgg ctgatccttc atctaaggaa tacggctcgc tttcaatcgc 50761 ggtgcagttt tatacagaag ccaaaacggt gatgatcgtc ccgaaaaccg tatttgttcc 50821 tcagcctaat gtcgattccg cagtcattcg tctgattctc cgagacggcc cggcagtgga 50881 cgtggaaaac gaatcctttt tctttcagct catcaaggca agctttgcac agcgccgtaa 50941 aacgctgctc aataacttag ttaacaatct gcctgaagga aaagcacaaa aatcaacgat 51001 tgaacaagtg ctcgaagaaa caaatattga cggtaagcgc cgaggtgaat ccctgtctat 51061 tgaggaattc gcagcgctgt ctaacggatt gtataaagcc cttttctaaa agggcttttt 51121 gttttgcgca ccacatggac tgccgctaca taggctagag aaggaccttt cattcaatga 51181 taagaaaaaa cttggactca gcgaaaaaag gcgctttctc aaggctcttt ctttcatgat 51241 gaggcttagt ctatgtgtgg agtgaggaac gtgcaatttc aaatagggga tatggtagcc 51301 agaaaatcct atcagatgga tgttttgttt cgaattatag gaatagagca aacaagcaaa 51361 ggaaattcaa ttgccatttt gcatggagat gaagtcaggc tgattgctga ttcggatttt 51421 tctgatctgg tggcagtgaa aaaggatgag cagatgatgc ggaaaaagaa agatgagagc 51481 agaatgaatg agtcgctcga attgctccgc caagattata agctgctcag agaaaagcag 51541 gagtactatg cgacaagcca atatcagcat caggagcatt atttccatat gccgggcaaa 51601 gtgcttcatc tggatggtga cgaagcatat ttgaaaaaat gcctgaatgt ctataaaaaa 51661 attggagtgc cggtctatgg catccattgc catgaaaaga aaatgtctgc ttctattgaa 51721 gtattgctcg acaaatatcg acctgacatc ctggtgatca cagggcatga tgcgtactcg 51781 aagcaaaagg gcggtattga tgatttgaat gcgtacagac attctaagca ctttgttgaa 51841 acagttcaaa cagcccgaaa aaagatccct cacttagatc agcttgttat ttttgcgggg 51901 gcctgccaat cccattttga atcactcatc agagcgggtg cgaattttgc aagttcaccg 51961 tcaagagtca atattcatgc gcttgatccg gtatatatcg tcgcgaagat cagctttacg 52021 ccgtttatgg aacggattaa tgtatgggaa gtgctccgta atacgctgac aagagagaaa 52081 gggcttggag gtattgaaac aagaggagtt ctgagaattg gtatgcctta taagtccaat 52141 taacagttga aaacctgcat aggagagcta tgcgggtttt ttattttaca taatgataca 52201 taatttaccg aaacttgcgg aacataattg aggaatcata gaattttgtc aaaataattt 52261 tattgacaac gtcttattaa cgttgatata atttaaattt tatttgacaa aaatgggctc 52321 gtgttgtaca ataaatgtag tgaggtggat gcaatggcga agacgttgtc cgatattaaa 52381 agatcgcttg atgggaattt aggtaaaagg ctgacgttaa aagcaaacgg tggccgccga 52441 aaaacgattg agcgttcggg cattttagct gagacgtacc cttctgtttt tgtgatacaa 52501 ctagatcaag acgagaactc gtttgaaaga gtttcataca gttatgctga tattttgact 52561 gagactgttg agctgacatt taatgatgac gccgcaagct cagtggcatt ttaacgggca 52621 gtgaaccttt tgtttactgc tttttgtttt gccctttttt ggtttccaat aattttaacg 52681 aaagttccat ctgatttaac aaaagataaa acagtcacat attatcgtga cgtgcacgaa 52741 tggctatcac ttctaaaaaa ggagttgttt cgtttgggca gacgtcgtgg agttatgtca 52801 gatgagttta aatatgagct ggctaaagac cttggttttt atgacacagt aaaaaatgga 52861 ggctggggtg aaattcgggc ccgcgatgcc ggtaacatgg tgaagcgtgc tattgaaatc 52921 gccgaacagc aaatggctca gaatcagaat aaccgataag gatgtgaccc gggggacgtg 52981 ctgttccctg gtttttttat tttggatata aatacataat gggctgaata tggatatgtt 53041 catcctgtac ttcaaatgtg atacaatgtt catacttatg tttagatgga gaagtaggtg 53101 aaagctatgc gtattttaga aaaagcgcca gctaagatca atctgtcact tgacgtcacc 53161 cgaaaacgcc cggatggcta tcatgaagtc gaaatgatca tgacgacaat tgatttagct 53221 gatcgaattg aattgacgga gcttgcagag gatgaagtga gggtttcctc ccacaaccga 53281 tttgtgcctg atgaccaaag aaacttagct tatcaggctg ccaagctgat caaggacaga 53341 tacaacgtga aaaagggagt ttccatcatg attacgaagg taattccggt ggctgccggt 53401 cttgccggcg gaagcagtga tgcggcggcg acactcagag ggctgaacag actgtggaat 53461 ttaaatctgt ccgcggaaac gcttgctgag cttggagcgg aaattggctc tgacgtttca 53521 ttttgtgtct atggcggaac tgcattagca acagggcgcg gcgagaaaat taaacatatc 53581 agcacgcctc cgcactgctg ggtcatttta gcgaagccga caatcggtgt ttcaactgct 53641 gaagtgtaca gagcgctgaa actggatggt atagagcatc ccgatgtaca aggcatgatc 53701 gaggcgatag aagaaaagag ttttcagaag atgtgcagcc ggttaggcaa tgtgcttgaa 53761 tctgttacac tcgatatgca tcctgaagtt gcgatgatca aaaaccagat gaaacgcttt 53821 ggtgcagatg ccgtgttaat gagcgggagc ggcccgacag tgtttggact ggttcagtat 53881 gagtcgaagg tgcagagaat ttataacggg ttaagaggct tctgcgatca agtttatgcg 53941 gtgagaatga tcggcgaaca gaacgctctt gattaaatcc gtatgttaag ttatattgat 54001 cttaaaatat tcggattttg ggggtgagtt catgaagttt cgtcgcagcg gcagattggt 54061 ggacttaaca aattatttgt taacccatcc gcacgagtta ataccgctaa cctttttctc 54121 tgagcggtat gaatctgcaa aatcatcgat cagtgaagat ttaacaatta ttaaacaaac 54181 ctttgaacag caggggattg gtactttgct tactgttccc ggagctgccg gaggcgttaa 54241 atatattccg aaaatgaagc aggctgaagc tgaagagttt gtgcagacac ttggacagtc 54301 gctggcaaat cctgagcgta tccttccggg cggttatgta tatttaacgg atatcttagg 54361 aaagccatct gtactctcca aggtagggaa gctgtttgct tccgtgtttg cagagcgcga 54421 aattgatgtt gtcatgaccg ttgccacgaa aggcatccct cttgcgtacg cagctgcaag 54481 ctatttgaat gtgcctgttg tgatcgttcg taaagacaat aaggtaacag agggctccac 54541 agtcagcatt aattacgttt caggctcctc aaaccgcatt caaacaatgt cacttgcgaa 54601 aagaagcatg aaaacgggtt caaacgtact cattattgat gactttatga aagcaggcgg 54661 caccattaat ggtatgatta acctgttgga tgagtttaac gcaaatgtgg cgggaatcgg 54721 cgtcttagtt gaagccgaag gagtagatga acgtcttgtt gacgaatata tgtcacttct 54781 tactctttca accatcaaca tgaaagagaa gtccattgaa attcagaatg gcaattttct 54841 gcgttttttt aaagacaatc ttttaaagaa tggagagaca gaatcatgac aaaagcagtc 54901 cacacaaaac atgccccagc ggcaatcggg ccttattcac aagggattat cgtcaacaat 54961 atgttttaca gctcaggcca aatccctttg actccttcag gcgaaatggt gaatggcgat 55021 attaaggagc agactcatca agtattcagc aatttaaagg cggttctgga agaagcgggt 55081 gcttcttttg aaacagttgt aaaagcaact gtatttatcg cggatatgga acagtttgcg 55141 gaagtaaacg aagtgtacgg acaatatttt gacactcaca aaccggcgag atcttgtgtt 55201 gaagtcgcga gactcccgaa ggatgcgtta gtcgagatcg aagttattgc actggtgaaa 55261 taataagaaa agtgattctg ggagagccgg gatcactttt ttatttacct tatgcccgaa 55321 atgaaagctt tatgacctaa ttgtgtaact atatcctatt ttttcaaaaa atattttaaa 55381 aacgagcagg atttcagaaa aaatcgtgga attgatacac taatgctttt atatagggaa 55441 aaggtggtga actactgtgg aagttactga cgtaagatta cgccgcgtga ataccgatgg 55501 tcgcatgaga gcgattgcat ccatcacgct ggatcacgaa tttgttgtac atgatattcg 55561 tgtgattgat ggaaacaatg gtcttttcgt tgcgatgccg agtaaacgca cccctgatgg 55621 agagttccgc gatattactc atcctattaa ttcaagcacg cgaggaaaga ttcaagatgc 55681 cgtgttaaat gagtatcatc gtctgggtga cactgaagca ttagaattcg aagaagctgg 55741 agcttcttaa aaaataacca aaaagcaagg actgctgaaa gggctgacat aagccttttg 55801 ccggcggtcc ttttttaatt ctgatttttc aaacttagtt gcactcaata gaaaattctt 55861 gcacttcatg aagtctcctt gaaatcagaa gatatttagg atatattttt ctatggataa 55921 aagggatatt ggaggccaat aaatggataa gcggtttgca gttgttttag cggctggaca 55981 aggaacgaga atgaaatcga agctttataa agtccttcat ccagtttgcg gtaagcctat 56041 ggtagagcac gtcgtggacg aagccttaaa attatcttta tcaaagcttg tcacgattgt 56101 cggacatggt gcggaagaag tgaaaaagca gcttggtgat aaaagcgagt acgcgcttca 56161 agcaaaacag cttggcactg ctcatgctgt aaaacaggca cagccatttc ttgctgacga 56221 aaaaggcgtc acaattgtca tttgcggaga tacgccgctt ttgacagcag agacgatgga 56281 acagatgctg aaagaacata cacaaagaga agcgaaagct acgattttaa ctgcggttgc 56341 agaagatcca actggatacg gccgcattat tcgcagcgaa aacggagcgg ttcaaaaaat 56401 agttgagcat aaggacgcct ctgaagaaga acgtcttgta actgagatca acaccggtac 56461 gtattgtttt gacaatgaag cgctatttcg ggctattgat caggtgtcta atgataatgc 56521 acaaggcgag tattatttgc cggatgtcat agagattctt aaaaatgaag gcgaaactgt 56581 tgccgcttac cagactggta atttccaaga aacgctcgga gttaatgata gagttgctct 56641 ttctcaggca gaacaattta tgaaagagcg cattaataaa cggcatatgc aaaatggcgt 56701 gacgttgatt gacccgatga atacgtatat ttctcctgac gctgttatcg gaagcgatac 56761 tgtgatttac cctggaactg tgattaaagg tgaggtgcaa atcggagaag atacgattat 56821 tggccctcat acggagatta tgaatagtgc cattggcagc cgtacggtta ttaaacaatc 56881 ggtagtcaat cacagtaaag tggggaatga tgtaaacata ggaccttttg ctcacatcag 56941 acctgattct gtcatcggga atgaagtgaa gatcgggaat tttgtagaaa ttaaaaagac 57001 tcaattcgga gaccgaagca aggcatctca tctaagctat gtcggcgatg ctgaggtagg 57061 cactgatgta aacctgggct gcggttcaat tactgtcaat tatgatggaa agaataagta 57121 tttgacaaaa attgaagatg gcgcgtttat cggctgcaat tccaacttgg ttgcccctgt 57181 cacagtcgga gaaggcgctt atgtggcggc aggttcaact gttacggaag atgtacctgg 57241 aaaagcactt gctattgcca gagcgagaca agtaaataaa gacgattatg tgaaaaatat 57301 tcataaaaaa taatcctaaa ttcggaggtt tatccatgtc taatcaatac ggagataaga 57361 atttaaagat tttttctttg aattcgaatc cagagcttgc aaaagaaatc gcagatatag 57421 ttggagttca attagggaaa tgttctgtca caagatttag tgacggggaa gtccaaatta 57481 atatcgaaga aagtattcgc ggatgtgatt gttacatcat ccagtctaca agtgaccccg 57541 ttaacgagca tattatggaa ctgctgatta tggtagatgc gttaaaacgc gcttctgcaa 57601 aaacgattaa cattgttatt ccttattacg gttatgcgcg tcaagacaga aaagcaagat 57661 cccgtgagcc aatcacagct aaacttttcg ctaacctgct tgaaacagcc ggtgcgactc 57721 gtgtgattgc acttgacctg catgcgccgc aaattcaagg attctttgat ataccgattg 57781 accacttaat gggtgttccg attttaggag aatattttga aggcaaaaat cttgaagata 57841 tcgtcattgt ttcaccagac catggcggtg tgacacgtgc ccgcaaactg gctgaccgac 57901 taaaagcgcc aattgcgatt atcgataaac gccgtccgcg tccaaacgtg gcggaagtca 57961 tgaatattgt aggtaacatc gaagggaaga ctgctatcct catcgatgac attattgata 58021 ctgcaggtac gattacactt gctgctaatg cgctcgttga aaacggagcg aaagaagtat 58081 atgcatgctg tacacaccct gtactatcag gccctgcggt tgaacggatt aataattcaa 58141 caattaaaga gcttgttgtg acaaacagca tcaagcttcc tgaagaaaag aaaattgaac 58201 gctttaagca gctttcagtc ggaccgcttc tggccgaagc gattattcgc gttcatgagc 58261 agcaatcagt cagctatctg ttcagctaaa ccatttttcg aggtttaaat ccttatcgtt 58321 atgggtattg tttgtaatag gacaactaaa acgacaagag gatggtgctg aatatggcaa 58381 ctttaacggc aaaagaaaga acggacttta ctcgttcgtc tcttcggaat atccgtactt 58441 caggacatgt tccaggtatc atatatggga aggatacggg taacaaacct gtgtcattag 58501 acagtgtgga gctcatcaaa acgctgaggg acgaaggcaa aaatgcagtc attacgcttg 58561 aggtcagcgg agaaaaacac tcagtcatgg taacagacct gcagacggac ccgctgaaaa 58621 atgaaatcac tcatgctgat tttcaagtag ttaatatgag tgaggacatt gaagtggaag 58681 ttccgattca tctgaccgga gaagccattg gagtgaaaaa cggaggcgta ctgcagcagc 58741 cgttatatgc acttactgta aaggccaagc caaaagccat tccgcaaacg attgaggctg 58801 atatttcaag cctcgatgta aatgaagtac tgacgattgc ggatttgcct gctggcggtg 58861 actactcctt taatcatgaa tcagatgagg ttgtggcttc aatccttcct ccgcagcagc 58921 aggaagcagc tgaggtcgat gaagaggaat ctgccgatgc tcagcctgaa ggtgaaaacg 58981 aacaataata gcttaaggcg taaccctccc gcggttacgt cttttgtgct agaatgagaa 59041 gaattatagc ccgtttatga agacgggagt tatgtgacta agggaggatt cgccatgctt 59101 gtgattgccg gtctcggaaa cccggggaag aactatgaaa atacacggca taatgtcgga 59161 tttatggtga tagatcagct tgcaaaggaa tggaatatag agctgaatca aaataaattt 59221 aacggattat acggaaccgg atttgtttcc ggcaaaaagg ttctacttgt taaaccgctt 59281 acatatatga atttatcagg agaatgtttg cggcctttaa tggactacta tgatgtcgat 59341 aacgaagatt tgacagtcat ttacgacgac cttgaccttc cgactggcaa gatccgttta 59401 agaacgaaag gaagcgccgg agggcacaat ggcatcaaat cactgatcca gcatcttgga 59461 acgtccgagt ttgaccgtat ccgcatcgga atcggccggc ctgtaaacgg catgaaggtc 59521 gttgattatg tgttaggctc ctttaccaag gaggaggcac ctgagatcga agaagcggtt 59581 gataaatctg tgaaggcttg tgaggcttct ttgagtaaac cgtttttaga agtcatgaac 59641 gaatttaacg caaaggtata aaatgtaaca acaaagtcca tactacacca aaatgacttt 59701 ttcatcagga ggacccttgt atggctttgc attattattg tcgtcattgc ggagtgaaag 59761 taggcagtct cgaatcttca atggtatcga cagactcact tggatttcag cacttaacaa 59821 atgaggaaag aaacgatatg atttcttata aagaaaatgg agatgtccat gttttgacga 59881 tatgtgaaga ctgccaagag gcgcttgacc gaaatccgca ttaccacgaa tatcacacat 59941 ttattcaata aaaagctttg gtgtagacac tagaccaaag cgtttttctg ttctcgcagg 60001 aaacagagag gaggggccat atggacaaca ttcaaacctt tataaaagaa agcgatgact 60061 ttaaatccat catcaacggt ttacacgagg gcctgaagga acagctgctc gcgggtctgt 60121 cgggttccgc gcgttctgtt tttacttctg ctctggctaa tgaaacgaat aagcctatct 60181 ttctcatcac ccataactta tatcaagccc agaaagtaac agatgatctg acttcacttc 60241 tagaggatcg gtctgtcctt ttgtaccccg tcaatgaact catttcatca gaaatcgcag 60301 ttgcaagccc tgaattgcgg gcgcagcgat tagatgtcat taatagacta acgaatggag 60361 aagcgccaat tgtcgttgct ccggtagctg caatcagaag aatgctgccg cctgttgagg 60421 tgtggaaaag cagccagatg ctcattcaag taggccatga tattgaacct gaccagcttg 60481 cctcacggct ggtagaggta gggtatgagc ggtctgatat ggtttctgcg cccggggaat 60541 tcagtattcg cgggggaatc attgacattt atccgctgac ttcagagaat ccggtgagaa 60601 ttgaactttt tgacaccgag gtggattcaa tccgcagctt taattcagat gatcagcggt 60661 caattgagac ccttacctcg atcaatatcg gtcccgcgaa ggaattaatt atcagaccgg 60721 aagaaaaagc gcgggcgatg gagaaaatcg atagtggtct tgccgcgagc ttgaaaaaat 60781 taaaggctga caaacaaaaa gaaatacttc atgcgaatat ttctcacgat aaagaacgct 60841 tgtctgaagg ccagacagat caggagctcg tgaagtatct ctcatatttc tatgaaaagc 60901 ctgctagttt actagattat acacctgata atacacttct gattttggat gaagtcagtc 60961 ggattcatga gatggaagaa cagcttcaaa aagaagaagc ggagtttata acaaatcttc 61021 ttgaggaagg gaagattttg catgacattc gtttgtcatt cagcttccaa aaaatagtgg 61081 ctgagcaaaa acggcctctg ctgtactact ctttattttt gcggcatgta caccatacga 61141 gcccgcaaaa tatcgtcaat gtgtcaggcc ggcaaatgca gagtttccat ggccaaatga 61201 acgtgcttgc gggcgaaatg gagcgtttta aaaaatcaaa tttcactgtt gtgttcttag 61261 gagcaaacaa ggaacgtacg cagaaattgt catctgtttt ggctgattat gatatcgagg 61321 ccgccatgac agacagcaaa aaagcgcttg ttcagggaca ggtctatatc atggaaggcg 61381 agctccaatc gggatttgag ctgccgttaa tgaagcttgc cgttatcacg gaagaagaac 61441 tgttcaaaaa ccgtgtaaag aagaagccgc gaaaacagaa gcttaccaat gcagagcgca 61501 tcaaaagcta ttctgagctt caaattggag attatgtcgt tcatattaat cacgggatcg 61561 gaaaatacct ggggattgaa actcttgaaa tcaacggcat tcataaagac tatttaaata 61621 tacattatca gggcagtgac aagctttacg tccctgtaga acaaattgat caggtccaaa 61681 aatatgttgg ctccgaagga aaagagccaa agctgtataa attaggcgga agtgaatgga 61741 agcgggtcaa gaaaaaagta gagacatccg ttcaggatat tgctgatgac ttaattaagc 61801 tgtatgccga aagagaagcg agcaagggct atgcgttttc tcctgaccat gagatgcagc 61861 gtgaattcga atcggctttc ccttatcaag agactgagga tcagctccgt tctattcacg 61921 aaatcaaaaa agacatggaa agagaacgtc cgatggaccg cttgctgtgc ggagatgtgg 61981 gctacggtaa aacagaggtt gccatacgtg ccgcgtttaa ggcgatcggt gacggaaagc 62041 aggtagctct gctcgttccg acaaccattt tggcacagca gcactatgaa accataaaag 62101 agcgcttcca ggactatccg attaatatcg gccttctcag caggttcaga acgagaaaag 62161 aagcaaacga aacaatcaaa gggctgaaaa atggaacggt tgatatcgtc atcgggacgc 62221 atcggctgct atcaaaggat gtcgtgtata aagacttagg gctcctcatc attgatgaag 62281 agcagcgttt cggtgtaacc cataaagaaa agatcaagca aataaaagcc aatgttgatg 62341 tattaacgtt aacagcaacg ccgattccgc gtacgctgca tatgtctatg cttggcgtaa 62401 gggacctttc agtcatcgag actccgccgg aaaatcgctt ccccgtacag acgtatgttg 62461 tggaatataa cggcgctctt gtcagagagg cgattgaacg tgagcttgca cgcggaggcc 62521 aggtctattt cttgtacaac cgggtagagg acattgagcg gaaagcggat gaaatttcaa 62581 tgctagtccc tgacgcgaag gtagcatatg cgcatgggaa aatgacagaa aatgaattag 62641 aaaccgttat gctaagcttc cttgaaggag aatcagacgt tctcgtcagc acaaccatta 62701 tcgaaactgg cgtggacatc ccaaacgtca atacgctgat cgtatttgac gccgacaaga 62761 tgggactttc tcagctttac cagctgcggg ggcgtgtcgg ccgttctaac cgtgtggcgt 62821 atgcgtactt cacgtatcgc cgggataaag tgctgacaga agtggctgaa aaaaggctgc 62881 aggctattaa agaattcaca gagttaggtt ccggttttaa aatcgcaatg cgtgacttaa 62941 cgattcgcgg agccgggaat cttcttggtg cccagcagca tggcttcatc gattcggtcg 63001 gatttgacct ctattcacaa atgctgaagg aggccattga ggagcgtaaa ggagacacag 63061 cgaagacaga gcagtttgaa acagaaattg atgtcgagct tgatgcgtat attccggaaa 63121 cttatattca agacggcaaa cagaaaattg atatgtataa acgcttcagg tctgtggcga 63181 caatcgaaga gaagaatgag cttcaagatg aaatgatcga ccgctttgga aactatccaa 63241 aagaagtcga atacttgttt actgttgcag aaatgaaagt ctatgcgaga caggaacgtg 63301 tcgagctgat taagcaggat aaagatgctg tcagattgac gatttctgaa gaagcaagtg 63361 ctgaaattga cgggcagaag ctgtttgagc ttggcaatca atatggcaga caaatcggac 63421 tgggaatgga agggaaaaaa ctcaaaatct ccatacagac gaaaggccgt agtgctgatg 63481 aatggctcga caccgtgctg ggcatgctga agggcttaaa agatgtgaaa aagcaaacca 63541 tttcatcaac gtaaattttg ttactctctg gtgtatatta catttgatgt gacggatact 63601 aatttcaagc gaggcggaag gtacataaag taactgcttt aggtctttcc cacatgtata 63661 taccatcaaa tgaaagagag gcaccagaga tgaaagcaac cggtatcgta cgtcgtattg 63721 atgacttagg tcgggtcgtg attcctaaag aaattcgaag aactctgaga atcagggaag 63781 gcgatccgct tgagattttt gtagatcgtg acggagaagt gattttgaaa aagtactctc 63841 cgatcagtga gcttggagac tttgcaaagg agtatgcaga cgcgctttac gacagcctcg 63901 gccattcagt gctgatttgt gatcgtgatg tatatattgc cgtgtccggc agctccaaaa 63961 aagattactt aaacaagtca atcagcgaaa tgctggaaag aacaatggat cagcgcagct 64021 ccgtgcttga gagtgatgcg aaatcagtac agcttgtgaa tggaattgat gaggacatga 64081 attcttatac tgtaggccca attgtggcga acggtgatcc gataggtgct gtggtgatct 64141 tttcaaaaga tcagacaatg ggcgaagtag agcataaagc cgttgaaaca gcagctggat 64201 ttttggctcg tcaaatggaa cagtaggtct tattcctttc ttcgaaaata ggtatgtaaa 64261 gaacagctct ccttgggacg ctgttctttt tcatgcgtgc cgaaaaagga atccaagggt 64321 tgggatgtgg tataataacc tcgtttttat ttgtgccgcg gtaatacgtg aaccgtattg 64381 cccctgacgt tgggaaggag cttttggatg gacgattcaa taggcgttaa acggcattgg 64441 atttggcagg gggcttttgt tttaattctg gcaggcgtca tcacaaaaat tttaagcgct 64501 gtttacagag tcccgtttca aaacattgtc ggcgatgttg gattttatat atatcagcag 64561 gtatacccct ttcttggtat tgcggtcatg ctgtccacat caggatttcc agtcattatt 64621 tcaaagctga tgaatgatta tagtgaaaaa aatcatcaca ccatattaaa aatatcagcg 64681 ttgtttttgt ctttaatcgg tattttatta tttctttgtt tatatctggg tgctgttcct 64741 attgcactct ttatgggaga ttcgcatcta gccgtgttaa ttcaagtggc cgcatacgcg 64801 tttctgcttt tcccatttgt cgcgttgcta agaggcggtt ttcaggggcg gcacgaaatg 64861 ctcccttcag ccttatcaca gatgacagag cagtttctgc gtgttgcggt gctcttgggt 64921 ttatcatttt ggctcgtgaa aaagggagcc tcgctttata ctgcgggagc ggcagccgct 64981 tcaggctctc ttgccggaag tttggttgca ttgataatac tggggttttt ttggttcaaa 65041 acgaaaagag acaaccaaac ggataggcaa aacgaaaatg tcatcacaac aaaagaattg 65101 acgaaaaaac tgcttttata ttcggtcaca atttgtgtaa gcagtttgct gcttttgttt 65161 atccagcttg ttgatgcttt gaatttatat gcattgcttt cgggtggtga ggcaagcgaa 65221 gaagcaaaat gcctaaaggg gatctatgat cggggacaac ccttgttgca gctcggttca 65281 gtttttgccg taagcattgc gacgtcactc gttccgtata tttctatggc tgtaaaaaac 65341 aaagagctga agatcatgaa agaaaaaatc acgtcatctt tgaaactatg ccttgtgctc 65401 ggtacaggcg catcggctgg gttgatttgc attctaaagc cggtaaatat catgctgttt 65461 caaaatggag aagggacagg tgcgttacaa gtatttagct gctccatttt gtttgcatcc 65521 ttggcggtaa cggcagcggc agtcttacag ggagcgggat acacagtttt tcctgcgata 65581 gcggtgggcg cgggtgttgc ggtgaaatgg gtgttaaaca cacttttggt tccgcgctat 65641 gggattgaag gcgcatcgct tgcgacagcg gcttcctttg cggctgtcgc cggccttaac 65701 ttgtatcagc ttcggcaaaa ggaatggctc gataagctta gaggcgtttt gattccgatt 65761 attggatctg ctcttttgat gtcagctgtt ttgcttgcgt atacgcgtct ctggactttc 65821 ttgtttcctg caacaggaag aggagcggct gtgattgaga gtctttctgc tgttgccatt 65881 ggtggcgcgg tgtttattta ttgtatgatg agattgggaa tatttacaga tgaagagctg 65941 aacagtgtgc cattcggcag caagttaagc aaattcatga gaaggagaga acaaaatggc 66001 gggtaaaatt acagtcgtcg gacttggtgc cggagacatg gaccaattga caattggtat 66061 acacaagctg ctgacgaagg cagatacgct gtatgtcaga accaaggatc atcctttaat 66121 tgaggagctt gaaaaagaaa cgaagaacat ccgtttcttt gatgatatat atgagaaaca 66181 tgatcagttc gaggcggtat atgaagaaat tgcagatatc ctctttgaag cggcgcggcg 66241 tgaggacgtg gtttacgctg tgccgggaca cccttttgtc gcagaaaaaa cagttcagct 66301 gctgacggag cggcaggaaa aggaaaacgt tcaagtgaaa gtcgcggggg gacaaagttt 66361 ccttgatgcc acattcaatg tcttgcaaat tgacccgatt gaaggttttc aatttgtgga 66421 tgccggcaca ttgtccgcgg atgagcttga gctcagacat catctgatca tatgtcaggt 66481 ttacgaccaa atgacggctt ctgaagtcaa gctgacattg atggagaagc tgcctgatga 66541 ttatgaggtc gtcattgtga ctgcagcagg cagccgtggc gaggagatca ggacagtgcc 66601 attatttgag ctggaccgca atgtcgcttt gaacaactta acaagtgtgt atattccgcc 66661 gattaaagaa gagaagctgc tttatcacga attctccacg ttccgaagca tcatcagaga 66721 gcttcgcgga cctaatggat gtccgtggga taaaaagcag acgcatcagt cattaaagca 66781 gtacatgatt gaagaatgtt atgagcttct cgaagctatt gacgaagaag acacagacca 66841 tatgatcgaa gagcttggcg acgttttgct tcaggtcttg cttcacgcgc aaattggtga 66901 agatgaaggt tatttcacaa ttgatgatgt cataaaagga atcagtgaaa aaatggtccg 66961 aagacatccc catgtgttta aagatgttaa ggttcaggat gaaaacgatg ttttagccaa 67021 ttgggaagat ataaaaaagg ccgaaaaaaa tacatctgaa tcatcattac tagacagcgt 67081 accgaaaacc cttccagctc tttcgaaagc agctaaattg cagaaaaaag cagcgaaggt 67141 cggttttgac tgggaagacg tcagcgatat ttgggaaaag gtaagtgagg aaatgaagga 67201 attttcttct gaggtttctg aagctcctca cgaacacaat cttaaagctg agtttggcga 67261 cattttgttc gcgctggtga atgtagcccg cttctacaaa atagagccag aggaagcgct 67321 gaccatgact aatgacaaat tccggagacg gttctcgtac attgaggaaa cagcgaagga 67381 agagggagtc gagttggctg atatgtccct tgaggacatg gacaaactgt ggaatgaagc 67441 aaaagaaact gagaggagat catagatatg agattagata aatttttgaa agtatcacgg 67501 ctgatcaaac ggcgtacact agcgaaggaa gtagctgacc aaggacgaat ctctattaac 67561 ggaaaccaag ctaaagctag ctctgacgta aaaccgggag atgaactaac ggtccgcttc 67621 ggccaaaagc ttgtaacggt tcaagttaat gaattgaaag acacgacgaa aaaagaagaa 67681 gctgcaaaca tgtacacgat tctaaaagaa gaaaaactcg gcgaataggc ttgttctaaa 67741 aaaacccccc acctcataca atgcagtaat aatgctaaaa gtatcgagga tatgggggct 67801 gaatagatga attcatatta tgatcaaaaa ggttcttcgt ctgttccgga acagcatgat 67861 gtgacaatga aaggccggaa gcatttagat atttctgggg ttaagcatgt ggagagtttt 67921 gataacgaag aattcctgct ggaaacggtg atgggaatgc tctccgtcag aggccaaaac 67981 ctgcagatga aaaatcttga tgtggaaaaa gggattgttt cgattaaagg cagggtattt 68041 gatttagtgt acttagacga acaacaaggg gataaagcta aagggttttt tagcaagttg 68101 tttaaatgac gctgacgaca caattctata caatgctagc gatgtccggt atgggtctct 68161 ggcttggtgc ttcgcttgat acataccggc tctttgtcat tcgtgccaaa acagccagat 68221 ggctattatt tattcatgat attcttttct ggattatgca agggctgctt ttcttttatg 68281 tcttgcttca tgtaaatgag ggagaattca ggatttacat ctttttagcg gttctgctgg 68341 gcgttgcgac gtatcagagc ctttgcaaac gaatctatat aaaaatactg aaattcgtca 68401 tttaccttgt tgtttctgtt tatcaattct tcaaaaaact cattcagcac gtgttatttc 68461 gtcctattgt gtggacatgc ggagcgatca tctggctggc ggcattttta ttcaagaaaa 68521 catacagcct gataggtttt ctcctgctgt gtctatataa aatagtcatg gttctgtgtt 68581 ttccgatccg ttttatcgcg aaacaatgtt tgaaacttct tcctgtgaaa atgcgtctaa 68641 cttttagacg ttattttgaa aaaggtgcag gatttctcaa aaagaagaag aaactattga 68701 taaccataag aacgaccatc acacggtttt tgaagagatg aaaggaggac cgtctggttt 68761 gaatttttcc agggaacgaa cgataactga aatacaaaac gactataaag aacaagtaga 68821 acggcaaaat cagctgaaga aacgaagacg caaagggctg tacagacggt taactgtatt 68881 cggcgcccta gtattcctga cggcaattgt gctggcaagc tctgtatggt cccaaacatc 68941 ttcccttagt gcaaaagaag aaaagaaaga acagcttgaa aaagaactga aaagtttaaa 69001 gacaaaacaa acggatttaa aagaagaaat atccaaattg aaggatgagg attacgtcac 69061 agagcttgcc agaagggact tattcatgtc tggagacgga gaaattatct tcaatgtgga 69121 gaagaagagc aagtagcctt gttgacactt aaatttttat ttaggtataa ttaagcaaac 69181 gatcttttta taagcctaag gaggagcact ttttttatgt cgattgaagt tggcagcaag 69241 ttgcaaggga aaattacagg tattacaaat tttggagcat ttgttgaatt gcctggaggc 69301 tcaaccggtc tcgttcacat tagtgaggta gctgataatt atgtcaaaga cattaacgac 69361 cacttaaaag tcggcgacca agttgaagtg aaagtcatca acgttgaaaa agacgggaaa 69421 attggtttat ctattaaaaa agctaaagac cgtccgcaag ccagacctag aaatgatttc 69481 cgtccgaaag aatcttttga acagaaaatg aataagtttt taaaagacag cgaagatcgc 69541 ttgtcatctt taaaacgcaa tacggaatca aaacgtggag ggcgcggagc aagaagagga 69601 taacttgctg ctttctataa aataaatgaa gcatccgttc atcccgacgg atgctttttt 69661 attatcctca ttctctttaa gagtcagaaa attacaacat taaagtttct gttgacgaaa 69721 gagacaaacc tttgtattat ataacttgtg cttagaagca caaaacaata tggcggtgta 69781 gctcagctgg ctagagcgta cggttcatac ccgtgaggtc gggggttcga tcccctccgc 69841 cgctaccata tttgtttggc ccgttggtca agcggttaag acaccgccct ttcacggcgg 69901 taacacgggt tcgaatcccg tacgggtcat cctaacaaat cggtttctct tgcagaagcc 69961 gatttttttc atttttagac aacattccgg aaattctttt cataaacgaa tatcaaggca 70021 gaaaccgtcg aagatttctt tggtattgtt accttctttt gacaaaatcc tatctgtgct 70081 ttcgctataa tgacaggcaa cgaatataac aggtgggaga tgagaggaat ggaaaaagca 70141 gaaagaagag tgaacgggcc aatggcggga caagctttgg aaaaactcca atcgtttttt 70201 aacaggggca cgaagctggt gactcatcat ttgcattcac tgtttttcta taaaggattc 70261 atttatgttg tcatcggatt tttgcttgga cgggctttca tattatccga ggtgcttcct 70321 ttcgcacttc ctttctttgg agcgatgctt cttatcagaa gagacaaagc gttttatgcg 70381 gttttggctg tgcttgcagg tgcgctgacc atatctccaa agcactcatt gctcatactg 70441 gcggcattgc tggcattctt cgtattttct aaagtggctg ccttcattac cgacgatcgt 70501 gttaaagcgc tcccgattgt cgtgttcttc tccatggctg cagcaagagc cgggtttgtt 70561 tatgcccaaa atggcgtatt tacaacctat gattatgtaa tggctatcgt tgaggctgga 70621 ctatcgttta tcttaacact gattttcctt cagagccttc cgatttttac tgtgaaaaaa 70681 gtgaaacaat cattaaaaat agaggaaatc atttgcttta tgattcttat tgcctctgtt 70741 ttaacggggc tggctggctt gtcctaccaa gggatgcagg cagaacatat attggctcgt 70801 tatgttgtgt tgagtttttc ctttattggc ggagcaagca tcggctgtac ggttggggtt 70861 gtgaccggcc tgattcttgg cttggcgaat atcggaaacc tatatcaaat gagtctgctt 70921 gctttttccg gtttattggg cggtttgctg aaggaaggga aaaaagcggg tgcagcaatt 70981 ggtttgatcg ttggatcact tcttatatct ttatatggtg aaggctctgc cggtctgatg 71041 acaacgctct atgagtcatt aatcgcagtc tgcctgtttt tgctcacacc tcaatctatt 71101 acgaggaaag tggcgagata tattccggga actgtcgagc atcttcaaga gcaacagcaa 71161 tacgctagaa aaatccgtga tgtcactgct cagaaggtag accaattctc caatgtattt 71221 cacgcgctgt ctgaaagctt tgcaaccttt tatcaagcat cagacgaaca gacagatgac 71281 agcgaagttg atctgttctt aagcaaaatc acggagcatt cctgccagac gtgctacaag 71341 aaaaacaggt gctgggtaca gaactttgat aaaacatatg acttaatgaa acaagttatg 71401 cttgaaacag aggaaaaaga atatgcatca aaccgaaggc tgaaaaaaga gtttcaacag 71461 tattgttcta aatccaagca ggttgaagag ctgattgagg atgagctcgc acatcatcat 71521 gcccatttga cactcaagaa aaaagtccaa gacagcaggc gccttgttgc tgaacagctt 71581 ttaggcgttt ctgaggttat ggccgacttt tctcgggaaa taaaaagaga gcgagaacaa 71641 cactttctgc aggaagagca aatcatagaa gcgcttcagc atttcggaat tgagattcag 71701 catgtcgaga tctatagtct tgaacaagga aatatcgata ttgaaatgac cattccgttc 71761 agcggacatg gagaaagtga aaaaatcatt gctcctatgc tttctgacat tctggaggaa 71821 caaattcttg tgaaagccga acagcactct ccgcatccga atggatacag ccatgtcgcc 71881 tttggatcaa caaaatcata cagggtgtcc acgggagctg ctcacgctgc gaagggcggc 71941 ggccttgtct ccggtgacag ctacagcatg atggagcttg gagccagaaa atatgctgca 72001 gcaatcagtg acggaatggg caatggcgca agagcgcact ttgaaagcaa tgaaacgatc 72061 aagcttcttg aaaaaatcct tgaatcgggc attgatgaaa aaatagcaat taaaacgatc 72121 aacagcatac tgtctctaag gacaactgac gaaatatatt ccacgcttga cctatctatt 72181 atcgatcttc aagatgccag ctgtaaattt ttgaaggttg gatcgacgcc cagctttatc 72241 aaacggggtg accaggtcat gaaagttcaa gcgagcaatc tgccaatcgg tattattaat 72301 gaattcgatg tggaggttgt gagtgaacag ctgaaagcgg gtgacctctt aattatgatg 72361 agtgatggca tttttgaggg gcctaagcat gtggaaaatc acgacttatg gatgaagcgt 72421 aaaatgaaag ggttgaaaac aaatgacccg caggagattg ccgatttgct tatggaagaa 72481 gtcatccgca caagatccgg ccaaattgag gacgatatga ctgttgttgt cgtccggatt 72541 gatcacaata caccgaagtg ggcatccatt cctgttccgg caatctttca aaacaaacaa 72601 gaaatttcat aacgcttccg tataaatcaa atttcttctg gcgaagatgg gaatatatga 72661 atctgagaat cctcgtattc tccaggagga atgaatgtga acaacggaca tttaaatcaa 72721 attttgctga taacggatgg ctgctcaaac catggggaag acccgcttgc aatggctgct 72781 tttgctaaag agcaggggat tacggtaaat gtcattggta taatggaaga aaatcaaatt 72841 gaccctgagg caatgaagga agtcgaaggg attgcacttg ccggaggagg cgtgcaccaa 72901 gtcgtttatg catctcagct ttcacaaact gttcaaatgg taacaaagaa agcgatgacg 72961 caaaccttac aaggtgtagt caatcaagaa ctgaaacaga ttctcggaaa gaatgtggaa 73021 atggaagagc tttctccgga aaaacgcggc gaagtcatgg aagtggtaga cgagcttgga 73081 gaaacggtgc atcttcaggt tttggttctt gttgatacaa gtgcaagtat ggcgccaaag 73141 cttccaacag taaaagaggc gctgattgat ttgtctgtaa gcctcaattc ccgaattggg 73201 aataacgaat ttgcgatgtg tatatttccc gggaaaaaac aagaggtcga gcttgtgctg 73261 aactggacac cgaagctgca atctctttcc acactctttg caaagctttc gacaggcggc 73321 atcacgccga caggtccggc gattcgtgaa gcgacactgc agtttgaaaa aatacgctca 73381 agaaggggca tgctggcaga tgatgaacga cgctttgacg agtttggcat gtagcctcaa 73441 gccgggtacg acaatcaaag gcaagtggaa tggaaacact tatacattgc gtaaacagct 73501 tggtaaaggg gccaatggaa ttgtgtattt ggcagaaaca tcagatggac atgttgcctt 73561 aaaggtgagt gatgacagcc tgtctattac ttctgaagtg aatgtcttga aatctttctc 73621 aaaggcccag tccgttacga tggggccttc tttttttgat acggatgatg cctatattcc 73681 cagtgccaat acgaaagttt cattttatgc aatggaatac ataaaagggc cgctgctttt 73741 gaagtatgtc agtgataaag gagcagagtg gataccggta ttaatgattc agctgttatc 73801 cagcttatcg gtgcttcacc agcaaggatg gatattcggc gatcttaaac ctgataatct 73861 gatcgtaact ggtccgcccg caaggatccg ctgcattgat gtgggcggca cgacaaagga 73921 aggccgggcg ataaaagagt atacggagtt ttatgacaga ggctattggg ggtatggaac 73981 aagaaaggca gagccatcct atgatctgtt cgcagttgcc atgattatga tcaacagtgt 74041 gcataaaaaa gaatttaaga aaacgaacca gcccaaagaa cagcttaggt ctctcatcga 74101 aggaaacccg ctgcttcaaa agtataaaaa agcgcttttt tcagccttga acggagatta 74161 tcaatccgca gatgaaatga aaaaggatat gctagacgcg gggcaaaaag cagcacaaag 74221 aaaacagcct ataaaagcat caccgcagcc tgccacacga caaagacagc aaaaaccgcg 74281 ccaaggaaaa ataacgaaga cgcgatatac cccaaaacag aaaccggcta agtcgggggg 74341 gttatttgaa acaacgctta tcgtgatcag tgttttagcg ctttatttcg cctatattat 74401 ctttttctta atctgaatgg tgcaaactgc agagcctatg cttcttcttt gcttggaggg 74461 gttgaaagtg ttaggatatg aatatcttta aaatacctgc tcattgtgag gaggacattg 74521 tgaaaagtgt caaagatttt ttaaacaaac acaatcttac gttaaaaggg gcgacaatca 74581 ttgtaggcgt ttccggcggt ccggactcaa tggctcttct tcacgcgttg catacgttat 74641 gcggccgttc agcgaatgtt attgcagctc acgttgacca tcggttcaga ggtgcggaat 74701 ccgaggagga catgcgtttt gtccaagctt attgtaaagc tgaacagctc gtgtgcgaaa 74761 cggctcaaat caatgtaacc gcatatgcac aggaaaaagg actcaataag caggctgcag 74821 cacgcgattg ccgctaccag ttttttgagg aaatcatgtc gaagcaccaa gcggactatc 74881 tggctcttgc gcatcatggt gatgaccagg ttgaaacaat gcttatgaaa ctggctaagg 74941 gtacgcttgg aacgggactt gcgggaatgc agccggttag acgttttggg acagggcgga 75001 tcatcaggcc gttcttaacc attacaaagg aagagatcct tcactattgc catgaaaacg 75061 gcttgagcta ccggacggat gaaagcaacg ccaaagatga ctacacaaga aacagattca 75121 gaaaaacagt gctcccgttt ttgaagcagg aatctccgga tgtgcataaa aggtttcaga 75181 aagtgagtga agcactgacg gaagatgagc aattcttaca gtcattaacg aaagatgaaa 75241 tgaataaagt aatcacaagc cagtctaata catcagttga aatcaattcc tctcaattgc 75301 ttgccctccc gatgccttta caaagaagag gagttcaact aatattaaac tatctttatg 75361 aaaacgttcc atcatccttt tcagcccatc acattcagca gtttctcgat tgggcggaaa 75421 atggcggtcc ttcaggagta ctggactttc cgaaagggct gaaggtggtc aaatcatatc 75481 agacatgttt gtttacattt gaacaatggc agtgcaaaaa tgttcccttt gaataccaaa 75541 ttagcggagc tgctgatgaa acggcagtgc tccctaatgg atatctgata gaggcaaggc 75601 attatgcgga ctcgcctgaa gaacatggga atgctgtttt tatcacaagt gaaaaaaagg 75661 tgcgatttcc cttaacaatc cggacgagaa aagctggaga ccggatcaaa ctaaaaggga 75721 tgaacggctc aaaaaaggta aaggatatat ttattgataa gaaattgcct ctccaagaaa 75781 gagacaactg gccgattgtg acggacgcaa gcggtgaaat tatctggata cctggcttga 75841 aaaaatcaat ttttgaagat cttgtgattc caaacagcga ccgcattgta ttacaatata 75901 gacagcatga aaagtgtagg gggcaagcaa aatcatgatg aaacatgata tcgagaaagt 75961 actgatctca gaggaagaga tacaaaagaa agtaaaagag ttaggtgcag aattaacgag 76021 cgagtatcaa gatacatttc cgttggcaat cggtgtgtta aaaggagcac ttccttttat 76081 ggcggatctt atcaagcata ttgatacata tttggaaatg gatttcatgg atgtatcaag 76141 ctacggaaat tctacggttt cttctggaga agtaaaaatc attaaagatt tggatacatc 76201 tgtagagggc cgggacatct taattattga agatatcatc gacagtgggt taaccttaag 76261 ttatctcgta gagctcttcc gataccgtaa agcaaaatca attaagattg ttaccctttt 76321 ggataaaccg agcggaagaa aagcggacat caaagcagac tttgtcggtt ttgaagttcc 76381 tgacgcgttt gtagtgggtt acggacttga ttatgctgag cgctatcgca atctgcctta 76441 tatcggagtg ttaaaaccgg cagtttatga aagctgatcg gcagcctgct tccgagatgg 76501 ttattgtttg tattggaatg attttctatg gtactattga acatagttgt gcttactgtg 76561 ggaggaggta aggaatgaat cgggtcttcc gtaataccat tttttattta cttattttat 76621 tagtagtaat cggggttgtg agctacttcc agacctcaaa tccgaaaaca gaaaatatgt 76681 cgtacagtac gttcatcaaa aacctggatg acgggaaagt tgatagcgta tcggttcagc 76741 ctgtcagagg tgtttatgag gtaaaagggc agctgaaaaa ctacgacaaa gatcaatact 76801 ttttgactca tgttcctgaa ggaaagggag cagaccagat atttaacgct ttgaaaaaga 76861 cagacgtaaa ggttgagccc gcgcaagaaa caagcggatg ggtgacgttc ctgacgacca 76921 tcatcccatt tgtcattatc tttattctgt ttttcttcct gctcaatcag gctcaaggcg 76981 gcggcagccg tgtcatgaac tttggcaaga gtaaagcgaa gctgtataca gaggaaaaga 77041 aacgcgtcaa atttaaagac gttgcagggg ctgacgaaga aaagcaagaa cttgttgaag 77101 ttgttgagtt tctgaaagat ccccgcaagt ttgccgagct cggcgccaga ataccgaaag 77161 gcgtgctttt agtcggacct ccgggtaccg gtaaaacatt gcttgccaag gcttgtgcag 77221 gagaagccgg cgtacctttc ttcagcatca gcggatctga tttcgttgaa atgtttgtag 77281 gggtcggtgc ttcccgtgtg cgtgacttgt ttgaaaatgc gaaaaagaat gcgccttgtt 77341 tgatcttcat tgatgaaatt gacgcagtcg gacgccagcg tggcgctggt ctcggcggtg 77401 gacacgatga acgtgaacag acgctaaacc aattgcttgt tgaaatggac ggattcagcg 77461 ctaatgaagg aattatcatc attgctgcga cgaaccgtgc ggacatcttg gacccagcct 77521 tacttcgtcc gggacgtttt gaccgtcaaa tcacagtgga ccgcccagat gtcattggcc 77581 gtgaagctgt attgaaagtc catgcgagaa acaaaccgct ggatgaaacg gttaacctaa 77641 aatcaattgc catgagaaca ccaggcttct caggcgctga cttagaaaac ctcttgaatg 77701 aagctgcgct tgtagcggct cgtcaaaaca agaaaaaaat cgatgcgcgt gatattgacg 77761 aagcgacgga ccgtgtaatt gccggacccg ctaagaagag ccgcgttatc tccaagaaag 77821 aacgcaatat cgtggcttat cacgaaggcg gacacaccgt tatcggtctc gttttagatg 77881 aggcagatat ggttcataaa gtaacgattg ttcctcgggg ccaggctggc ggttatgctg 77941 ttatgctgcc aagagaagac cgttatttcc aaacaaagcc ggagctgctt gataaaattg 78001 tcggcctctt gggcggacgt gttgctgaag agattatctt cggtgaagtc agcacagggg 78061 cgcacaatga cttccagcgt gcgacgaata ttgcaagacg aatggttaca gaattcggta 78121 tgtcagaaaa actgggaccg ttgcaatttg gacagtctca gggcggtcag gtattcttag 78181 gccgtgattt caacaacgaa cagaactaca gtgatcaaat cgcttacgaa attgatcagg 78241 aaattcagcg catcatcaaa gaatgttatg agcgtgcgaa acaaatcctg actgaaaatc 78301 gtgacaagct tgaattgatt gcccaaacgc ttctgaaagt tgaaacgctt gacgctgaac 78361 aaatcaaaca ccttatcgat catggaacat tacctgagcg taatttctca gatgatgaaa 78421 agaacgatga tgtgaaagta aacattctga caaaaacaga agaaaagaaa gacgatacga 78481 aagagtaatt cgctttcttt ctaaaaaaac tgccggctga cgctggcagt ttttttatgt 78541 aaatgattgg ctcagctgcg gcttttacaa tcatccaatt ctggtatcga tttgtttaca 78601 aatgagccgc tgatcgtgta tggtattgta gaatgtttgt aaaaagtaaa gtagagaaac 78661 tattcaaaag tggtgataga ggttgttact ggttatcgat gtggggaaca ccaatactgt 78721 acttggtgta tatcatgatg gaaaattaga atatcactgg cgtatagaaa caagcaggca 78781 taaaacagaa gatgagtttg ggatgatttt gcgctcctta tttgatcact ccgggcttat 78841 gtttgaacag atagatggca ttattatttc gtcagtagtg ccgccaatca tgtttgcgtt 78901 agaaagaatg tgcacaaaat actttcatat cgagcctcaa attgttggtc caggtatgaa 78961 aaccggttta aatataaaat atgacaatcc gaaagaagta ggggcagaca gaatcgtaaa 79021 tgctgtcgct gcgatacact tgtacggcaa tccattaatt gttgtcgatt tcggaaccgc 79081 cacaacgtac tgctatattg atgaaaacaa acaatacatg ggcggggcga ttgcccctgg 79141 gattacaatt tcgacagagg cgctttactc gcgtgcagca aagcttcctc gtatcgaaat 79201 cacccggccc gacaatatta tcggaaaaaa cactgttagc gcgatgcaat ctggaatttt 79261 atttggctat gtcggccaag tggaaggaat cgttaagcga atgaaatggc aggcaaaaca 79321 ggaaccaaag gtcattgcga caggaggcct ggcgccgctc attgcgaacg aatcagattg 79381 tatagacatc gttgatccat tcttaaccct aaaagggctg gaattgattt atgaaagaaa 79441 ccgcgtagga agtgtatagg aggtttagta atggattatt tagtaaaagc acttgcgtat 79501 gacggaaaag ttcgggctta tgcagcgaga acgactgata tggtaaatga ggggcagaga 79561 cgccatggta cgtggccgac agcatccgct gcactaggcc gtacaatgac agcttcactt 79621 atgctcggcg ctatgctgaa gggcgatgat aagctgaccg tgaaaatcga gggcggaggt 79681 ccgatcggag ctattgtagc tgatgccaat gccaaaggag aagtcagagc ctatgtctct 79741 aacccgcaag ttcattttga tttaaatgaa caaggtaagc ttgatgtcag acgtgcggtt 79801 ggaacaaacg gaacgttaag tgtcgtaaaa gatttaggtt tgcgcgagtt cttcacagga 79861 caagtagaaa tcgtttcagg agaattagga gatgatttta cttactatct tgtgtcatct 79921 gagcaggttc cttcatcagt gggcgtaggt gtgctcgtaa atcctgacaa taccattctt 79981 gcggcagggg gctttattat tcagctgatg ccgggaacag atgatgaaac aatcacaaaa 80041 attgaacagc gtctatctca agtagagccg atttctaagc tcatccaaaa agggctgaca 80101 ccagaagaaa ttttagaaga agtcctaggc gagaaacctg agattttgga aacgatgcct 80161 gtcagattcc attgcccttg ttcaaaagaa cggttcgaaa cagccatttt aggactaggc 80221 aaaaaagaaa ttcaagatat gatagaagaa gatggacaag ccgaagcagt atgccatttt 80281 tgtaatgaaa agtacttatt tacaaaagaa gagctggaag ggcttcgtga ccaaactacc 80341 cgctaagctc tttagcgggt ttttaatttg agaaaagggg ctgaaagcag gtttgaaatc 80401 aagaacaatc tggaccatta ttttaggggc gctgttggtt tgctgtattg ctgttgcata 80461 tacgctgacg aaatcccaag ccggcgcatc gtcatccggt gagtctattg cgactatcgg 80521 aggcaagagt gtgacaagag aagaatggct gaaagaaatg gaagatcagt atggtaagtc 80581 aacgcttgaa gatatgatca atgtccgagt tgttgagcag ctggctaaaa agaacaaact 80641 taaaatatcc aaaagcgaag ttgatcgtga gtttttgctg attaaagcgg tcaataattc 80701 cttttacgaa gatgaacata cgacggagaa agagtggaaa gaccaaattc gttataatat 80761 cctccttgag gatttgttaa caagggatat cgatatctca aacaaagaat tggaatcatt 80821 ctataataaa aataaggaac tatatcagtt tgatgattcg tatcgaattc ggcacattgt 80881 tgtaaaagat gaagaagaag caagagaagt cctgaaagaa ctgaaaggcg gatcaagctt 80941 tgaagctgtc gctgccgaaa gatctacaga cagatataca tcaccatacg gcggagattt 81001 aggttttgtc acagaggcat cagacaacat tccatcagca tacattgaag aggcgaaaac 81061 actcaaagag gatgaatggt ctcaggaacc aataaaggtc agcaacggat atgccattat 81121 ccagctgaaa gaaaaactaa aggcaagaac gttctcattt gatgaagtaa aggaccagat 81181 cagacggcaa atcgcaatgg atcagctagg cgataaagcg acagttaaga cactttggaa 81241 agaagccgat gtatcttggt tttatgggga aaaaagtact aagtgattga caaaaaattt 81301 tgaaattgat agattatata cataatacca atacaaatag tcggaaattg aggtgtcgag 81361 aatggtacgt gtagcaaact ccattactga attaattggg aatacgccaa tcgttaaatt 81421 aaatcgcctt gcagatgaaa acagtgcgga tgtatatcta aaacttgaat acatgaaccc 81481 tggaagcagt gtaaaagacc gtatcggttt agctatgatt gaagcggctg aaaaagaagg 81541 aaaattaaaa gccggtaata caatcattga accgacaagc ggaaatactg gaatcgggct 81601 tgcaatggtt gctgctgcta aaggattaaa agccattttg gttatgcctg atacaatgag 81661 catggagcgc cgcaaccttc ttcgcgcata tggtgctgag cttgtgctga ctcctggtgc 81721 ggaaggcatg aaaggtgcta ttaagaaagc tgaagagctt gctgaaaagc acggatactt 81781 tgtgccgcag cagtttaaca acccttctaa ccccgaaatt caccgccaaa caacgggtaa 81841 agaaatcgtt gagcaattcg gtgatgatca gcttgacgca tttgtagccg gaatcggaac 81901 gggcggaacg attacgggag cgggcgaagt gctgaaggaa gcataccctt ccatcaagat 81961 ttatgctgtt gaaccgtcag attccccagt gctttcagga ggaaaaccag gcccccacaa 82021 aattcaggga atcggagcag gattcgtgcc ggacatctta aacactgaag tatatgatga 82081 aatcttccct gtgaagaatg aagaagcatt cgaatatgcc cgcagagctg cacgtgaaga 82141 aggaattctc ggaggcatct catcaggtgc ggcaatttat gctgctcttc aagtagcaaa 82201 aaaactcgga aaaggcaaaa aagtattggc catcattcca agtaacggcg aacgttatct 82261 aagcacgccg ctgtaccaat tcgattaaaa aaagccaaaa ctcccggttc gccgggagtt 82321 tttttatatt tcgtgcatca aatatgccat gtctgcgacg aatgttattc ttggaagaga 82381 aattcacttt tttcactaac aacattgctt tacaattaaa aacaagtaaa aaagaaaata 82441 gaggaatgat acaaatggca caacgcagac cggcaggcaa aaaaatacct tttcaaaaag 82501 actcattctt acaacaattt gagaaacttg cgcaatcccg gaaacatcat gtacttctcg 82561 aaagtgcaag aggcggcaga tatagtatag ccggtcttga tccaattgcg actgtgaaag 82621 gaaaagacgg aataactaca attaagcatg gtgatgagat gctgtttaaa gaaggtgatc 82681 cattacgggc cttccacagc tggtttaaaa cactggaaac agaaacgaat catgagttcc 82741 ctgactttca aggcggggca atcgggtttc tcagctatga ttacgcacgg tacattgaaa 82801 attttaaaat gctctcatta gatgatttag aaacaccaga tatttatttt cttgtttttg 82861 atgatatagc agtttatgac catcaagaag agtctctatg gctgattact catgttaatg 82921 gttctgatca ggaaacagcg gatgtgaagc tatctgagtt agagcagatg tggttgactg 82981 agcttcccgc tgtcacttcg cgagagatga agcctgaaac agctggttct ttcgcggcgc 83041 catttaccga ggatgggttc tcacaagctg tagagaaaat caaacaatac attgccagcg 83101 gagatgtgtt tcaagtcaat ctatcaataa ggcagtcaca gtcactgtct gtccacccat 83161 atcaaattta caaaaccttg agagaagtaa atccttctcc ttatatggcg tatttagaaa 83221 cacctgattt ccaaatcatt tgcggatcgc ctgaactgct tgtcagcaaa aagggcaagc 83281 tattagagac gagaccgatt gcgggcaccc gttccagagg gaaaacaaat gaagaagacg 83341 aggcgcttgc aaacgaattg atacacaatg aaaaagaacg cgcggaacat gtcatgctgg 83401 ttgatcttga gcgaaatgat ctgggaagag tatcacgtta cgggtctgtg cgcgtaaatg 83461 aattcatggc aattgaaaaa tactcgcatg tgatgcacat tgtgtctaat gtccaaggtg 83521 aactgcagga tgggtatgat gctgtagata ttattcatgc tgtgtttccc ggaggaacca 83581 ttactggtgc accgaaagta agaacgatgg aaattataga agaacttgag ccgacacgcc 83641 gagggcttta tactggatct ataggatggt ttggatataa tcacgatctg cagtttaata 83701 tcgtcattcg aaccatttat gcaaccggag ggcaggcatt tatgcagtcc ggtgcaggag 83761 ttgtgattga ttctgttccg aagcacgaat acaaggaatc attcaaaaaa gcttttgcga 83821 tgcaaagagc attagagctg agcgaagaag agacaaaaat tagatgaggt gagcggagaa 83881 atgattttaa tgattgataa ctacgattca ttcacgtaca acttggtaca gtatttgggc 83941 gagcttgggg aagagctggt tgtgaaacgc aatgacagca tcacaatcga tgaaattgaa 84001 gaactgtctc cggactttct gatgatatct cccggaccgt gcagccctga tgaggcggga 84061 atcagcctcg aagcaattaa acatttcgca gggaaaattc ctattttcgg tgtatgtctc 84121 ggacatcagt ccatcgcaca agtgttcggt ggtgatgttg ttagggcaga acggcttatg 84181 cacgggaaaa cctcggatat cgagcatgac ggcaaaacca tttttgaagg gttgaaaaat 84241 ccccttgttg cgacgcgata ccactcgctg atcgtaaaac ctgagacgct gccaagctgt 84301 tttacagtaa cagcacaaac gaaagaagga gaaatcatgg ctattcgcca caatgacctc 84361 ccgatagagg gtgtgcaatt tcacccagag tctattatga cctcctttgg gaaagaaatg 84421 ctcagaaatt ttattgagac atatcgcaag gaagttattg cgtgatgata tatgtgaacg 84481 gccggtatat ggaggagaaa gatgcagttc tttctccttt tgaccatggg tttttatatg 84541 ggatcggtgt tttcgaaacc ttcaggctct acgaaggctg cccgtttttg cttgattggc 84601 atatagagag gcttgaacgc gcgcttaagg atctgcaaat cgaatatact gtttcaaagc 84661 atgagatcct tgagatgctg gacaagctgc ttaagctaaa tgatatcaag gatggcaatg 84721 cccgcgtcag actgaacata tcagcgggaa tcagcgataa aggctttgtc gcccagacgt 84781 acgataagcc caccgtttta tgctttgtga atcagctgaa accagaaagt cttcctttgc 84841 aaaaagaagg aaaggtttta tcgatacgga gaaacactcc agagggatcg ttccggttaa 84901 aatctcatca ttatctaaat aatatgtatg cgaaacggga aattggaaat gatccgcgtg 84961 tcgagggaat tttcttaacg gaggatggag ctgttgcaga gggtatcata tctaatgtct 85021 tctggagaaa aggtcgctgt atctatacgc catcgcttga taccggtatt ctggacggcg 85081 tcacgagacg ttttatcata gaaaatgcaa aggatatcgg cctggagctc aaaacgggcc 85141 gatatgagct agaagctctc ttgacagctg acgaagcgtg gatgacgaac tcggttcttg 85201 aaatcatccc gtttactaaa atagaagaag taaactatgg aagccaaagc ggagaagcaa 85261 cctccgctct tcaattgtta tacaaaaaag aaataaagaa catgattcat gaaaagggag 85321 gaagagcatg gcgcagcaca caatagatca aacacaagta atccacacta agcccagcgc 85381 tttatcatat aaagagaaga cgctggtgat gggaatttta aacgtaacgc ctgactcttt 85441 ctcggacggc ggaaaatatg acagcttgga caaggcgctg ctgcacgcga aagagatgat 85501 cgatgatggt gcccatatca ttgatattgg aggggaatcg acaaggcctg gcgctgagtg 85561 cgtatctgag gatgaggaga tgtccagagt cattccggtg attgagcgga ttacgaaaga 85621 gcttggtgtt cctatttctg tagacacgta caaggcttct gtcgcagatg aagcagtgaa 85681 agccggtgca tccattatca atgatatttg gggagccaaa catgatccga agatggcttc 85741 cgttgcagct gaacataatg ttccaattgt actcatgcat aaccgccctg aaagaaacta 85801 caatgactta ttgccggata tgctgtcgga cttaatggag agtgtaaaaa ttgctgttga 85861 ggccggagta gacgagaaga acattattct tgatcctggt atcggtttcg cgaaaaccta 85921 tcacgataac ttggcagtga tgaacaaact agagattttc agcggattgg gatatccggt 85981 tcttctggca acctcccgaa aaagattcat cggacgtgtt ctggatcttc cgcctgagga 86041 gcgggctgag ggcacaggcg cgactgtgtg tctcggcatt caaaaaggct gtgacattgt 86101 cagggtccat gatgtaaagc aaattgccag aatggcgaaa atgatggacg cgatgctgaa 86161 taagggaggg gtgcaccatg gataaagttt atgtagaagg tatggagttt tacggatatc 86221 acggtgtgtt cacagaagaa aacaaacttg gccagcggtt taaagtcgat ttaaccgctg 86281 agctggattt aagcaaagct ggacagacag acgaccttga gcaaacgatc aactatgctg 86341 agctctatca cgtatgtaaa gatatcgtgg aaggggagcc tgtgaaattg gtggaaacgc 86401 tggcggaacg tattgctggc actgttctcg gaaaatttca gcctgttcag caatgtacgg 86461 tgaaagtgat taagccagac ccgccaattc ccggacacta taaatcagta gcaattgaaa 86521 ttacgagaaa aaagtcatga acaacatagc ttatattgca cttggatcta atattggaga 86581 tagagaaacg tatttaaggc aagcagtggc tttactgcat cagcatgctg cggtgacagt 86641 cactaaagtg tcgtctattt acgaaactga cccggtcgga tacgaagatc aagctcaatt 86701 tttgaatatg gctgttgaaa tcaagacatc attgaaccct tttgaactcc ttgaactgac 86761 gcagcagata gaaaatgaat taggcagaac aagggaagta agatgggggc cgcggacggc 86821 agaccttgac attttgttat ttaatcgtga aaatattgaa acagagcaac taattgttcc 86881 gcatccgaga atgtatgagc gtttgtttgt ccttgcgccg cttgcggaaa tttgccagca 86941 ggttgaaaaa gaggctacaa gcgccgaaac agaccaagaa ggtgtaagag tatggaagca 87001 gaaatctggg gtagacgaat tcgtgcattc agaaagctga aaggttatac tcaagaagga 87061 tttgcaaaag cattaggtat atcagtttct attctcggcg aaattgaacg cggaaaccga 87121 ttgccgtctg ctgccatcat tcaagatgca gcagatgttt taaatataag tgcggacgaa 87181 ttggcgccgc cagaaaaata gaacaaatga aaggaggaga aaaattgttc aaaatcggag 87241 atattcaatt gaaaaaccgg gttgtgctcg cacctatggc tggtgtctgc aactctgcgt 87301 tcagattgac tgtaaaggaa ttcggagccg gattggtatg cgctgaaatg gtcagtgaca 87361 aagcgatcct ttacaacaat gcaagaacaa tgggtatgct ttatattgat gaacgtgaga 87421 aaccactgag ccttcaaatt ttcggaggaa aaaaggaaac ccttgtggaa gcggcgaagt 87481 ttgtagacca aaacacaact gctgatatca ttgatattaa catgggatgt cccgtgccga 87541 agattacaaa atgcgatgcg ggagccaaat ggcttctcga tcctgataag atttacgaaa 87601 tggtttctgc agtagtggat gctgttaata agccagttac agtgaaaatg agaatgggct 87661 gggatgaaga ccacattttc gcagtgaaaa atgcacaggc tgtagaacgt gcgggcggta 87721 aagcagtggc gcttcacggc cgtacgagag tgcagatgta cgaaggaacg gcaaactggg 87781 atatcatcaa agaagtaaaa caatcagtat cgattccggt tatcggaaac ggcgatgtta 87841 agacaccgca ggatgctaag cgtatgctcg atgagacagg agtagacggg gtcatgatcg 87901 gacgcgctgc attgggtaac ccgtggatga tttaccgtac ggttcagtat cttgaaacag 87961 gtaaattaaa agaagagccg caagtacgcg aaaaaatggc cgtatgcaaa ctgcatcttg 88021 accgcctgat tgacttaaaa ggtgaaaacg tagcggtaag agaaatgaga aagcacgctg 88081 catggtatct gaaaggcgtg aaaggcaatg cgaacgttcg taatgaaatc aatcattgcg 88141 agacgagaga agagtttgta cagcttttag atgcatttac ggttgaagtt gaggcaaaag 88201 agcttcaaaa tgcaaaagta ggataatact cacctctatt tgctgctcac tgctagtttt 88261 acgctggcag tttttctgct tttttcatga aacaatatct gtaatggagt gataacaatg 88321 agtcaagaag agcataacca tgaagaattg aatgatcagc tgcaagtcag acgcgataaa 88381 atgaatcagc tgagagataa cggcatcgat ccattcggcg cacgttttga aagaactcat 88441 cagtctcaag aagttatttc ggcatatcaa gatctaacca aagaagagtt agaagaaaaa 88501 gcgattgaag ttacaatcgc aggccgcatg atgacaaaac gcggcaaagg aaaagccggc 88561 tttgcccatc ttcaggattt agaaggccaa atccaaatct acgtaagaaa agacagtgtc 88621 ggtgacgacc aatatgaaat cttcaagtct tctgacctcg gtgatcttat cggcgtaacc 88681 ggaaaagtct tcaaaacaaa tgtaggcgaa ttgtctgtta aagcaacttc ctttgaattg 88741 ctgacaaaag cgcttcgtcc gcttcctgac aaataccatg gtttaaaaga cgttgagcag 88801 cgctaccgtc agcgctatct ggatcttatc gtaaacccag acagcaaaca tacgttcatt 88861 acacgaagca agatcattca agctatgaga aggtaccttg atgatcatgg atacttagaa 88921 gtagaaacac ctacaatgca cagcattcct gggggagctt ctgcacgtcc gtttatcact 88981 caccacaacg cgttagacat tccactctat atgcgtattg ctatcgaact gcacctaaaa 89041 cgtctaattg tcggcggttt agaaaaagta tatgaaatcg gccgtgtttt ccgtaacgaa 89101 ggtgtctcta cacgccataa ccctgaattt acaatgattg agttatatga agcatatgcg 89161 gactataaag atatcatgag cttaactgaa aaccttgtcg ctcatatcgc ccaagaagtg 89221 cttggcacaa ctacgattca atacggggaa gagcaaatcg accttaaacc ggagtggaaa 89281 agaatccata tggttgacgc agtcaaagaa gcgaccggcg ttgatttctg ggaagaggtt 89341 actgttgagc aggcgcgtga atatgcaaaa gaacatgaag tagaaattaa agactctatg 89401 acagtaggcc atatcatcaa cgaattcttc gaacaaaaaa ttgaagaaac gcttattcag 89461 ccaacgttta tttacgggca tcctgtagaa atttctcctc ttgctaagaa aaaccctgag 89521 gacccgcgtt ttacagaccg ttttgagctg tttatcgttg gccgtgaaca tgccaacgcg 89581 tttacagagc tgaatgatcc tattgatcaa agagaacgct ttgaagcgca attaaaagag 89641 cgtgaagccg gtaatgatga agctcattta atggatgaag actttgttga agctctggaa 89701 tacggtatgc cgccaacagg aggtttaggc atcggtatcg accgtctggt tatgctgctg 89761 acgaatgccc cttctattcg cgatgtgctg ttattcccgc aaatgagaca acgctaataa 89821 aaaagagcgg tatcctccat agggaaagga tgccgctctt tttaaatccc ttagtatttc 89881 ttcaaaaaaa ctattgcact attatttact aggtggtata ttattattcg ttgccgctaa 89941 acaaggcgat aacgaaaaaa agaacttcaa aaaaagttat tgacttcact gagtcaacga 90001 gttataataa taaagtcgct tgaacgaagt gaacaaaatg atctttgaaa actaaacaag 90061 acaaaacgta cctgttaatt cagtttttaa aaatcgcaca gcgatgtgcg tagtcagtca 90121 aactacttta tcggagagtt tgatcctggc tcaggacgaa cgctggcggc gtgcctaata 90181 catgcaagtc gagcggacag atgggagctt gctccctgat gttagcggcg gacgggtgag 90241 taacacgtgg gtaacctgcc tgtaagactg ggataactcc gggaaaccgg ggctaatacc 90301 ggatggttgt ttgaaccgca tggttcaaac ataaaaggtg gcttcggcta ccacttgcag 90361 atggacccgc ggcgcattag ctagttggtg aggtaatggc tcaccaaggc aacgatgcgt 90421 agccgacctg agagggtgat cggccacact gggactgaga cacggcccag actcctacgg 90481 gaggcagcag tagggaatct tccgcaatgg acgaaagtct gacggagcaa cgccgcgtga 90541 gtgatgaagg ttttcggatc gtaaagctct gttgttaggg aagaacaagt gccgttcgaa 90601 tagggcggta ccttgacggt acctaaccag aaagccacgg ctaactacgt gccagcagcc 90661 gcggtaatac gtaggtggca agcgttgtcc ggaattattg ggcgtaaagg gctcgcaggc 90721 ggtttcttaa gtctgatgtg aaagcccccg gctcaaccgg ggagggtcat tggaaactgg 90781 ggaacttgag tgcagaagag gagagtggaa ttccacgtgt agcggtgaaa tgcgtagaga 90841 tgtggaggaa caccagtggc gaaggcgact ctctggtctg taactgacgc tgaggagcga 90901 aagcgtgggg agcgaacagg attagatacc ctggtagtcc acgccgtaaa cgatgagtgc 90961 taagtgttag ggggtttccg ccccttagtg ctgcagctaa cgcattaagc actccgcctg 91021 gggagtacgg tcgcaagact gaaactcaaa ggaattgacg ggggcccgca caagcggtgg 91081 agcatgtggt ttaattcgaa gcaacgcgaa gaaccttacc aggtcttgac atcctctgac 91141 aatcctagag ataggacgtc cccttcgggg gcagagtgac aggtggtgca tggttgtcgt 91201 cagctcgtgt cgtgagatgt tgggttaagt cccgcaacga gcgcaaccct tgatcttagt 91261 tgccagcatt cagttgggca ctctaaggtg actgccggtg acaaaccgga ggaaggtggg 91321 gatgacgtca aatcatcatg ccccttatga cctgggctac acacgtgcta caatggacag 91381 aacaaagggc agcgaaaccg cgaggttaag ccaatcccac aaatctgttc tcagttcgga 91441 tcgcagtctg caactcgact gcgtgaagct ggaatcgcta gtaatcgcgg atcagcatgc 91501 cgcggtgaat acgttcccgg gccttgtaca caccgcccgt cacaccacga gagtttgtaa 91561 cacccgaagt cggtgaggta accttttagg agccagccgc cgaaggtggg acagatgatt 91621 ggggtgaagt cgtaacaagg tagccgtatc ggaaggtgcg gctggatcac ctcctttcta 91681 aggatatttt acggaatata agaccttggg tcttataaac agaacgttcc ctgtcttgtt 91741 tagttttgaa ggatcattcc ttcgaaacgt gttctttgaa aactagataa cagtagacat 91801 cacattcaag taatacaaga tatcacatag tgattctttt taacggttaa gttagaaagg 91861 gcgcacggtg gatgccttgg cactaggagc cgatgaagga cgggacgaac accgatatgc 91921 ttcggggagc tgtaagcaag ctttgatccg gagatttccg aatggggaaa cccaccactc 91981 gtaatggagt ggtatccata tctgaattca taggatatga gaaggcagac ccggggaact 92041 gaaacatcta agtacccgga ggaagagaaa gcaaatgcga ttccctgagt agcggcgagc 92101 gaaacgggat tagcccaaac caagaggctt gcctcttggg gttgtaggac actctgtacg 92161 gagttacaaa ggaacgaggt agatgaagag gtctggaaag gcccgccata ggaggtaaca 92221 gccctgtagt caaaacttcg ttctctcctg agtggatcct gagtacggcg gaacacgtga 92281 aattccgtcg gaatccggga ggaccatctc ccaaggctaa atactcccta gtgaccgata 92341 gtgaaccagt accgtgaggg aaaggtgaaa agcaccccgg aaggggagtg aaagagatcc 92401 tgaaaccgtg tgcctacaag tagtcagagc ccgttaacgg gtgatggcgt gccttttgta 92461 gaatgaaccg gcgagttacg atcccgtgca aggttaagca gaagatgcgg agccgcagcg 92521 aaagcgagtc tgaatagggc gcatgagtac gtggtcgtag acccgaaacc aggtgatcta 92581 cccatgtcca gggtgaagtt caggtaacac tgaatggagg cccgaaccca cgcacgttga 92641 aaagtgcggg gatgaggtgt gggtaggggt gaaatgccaa tcgaacctgg agatagctgg 92701 ttctctccga aatagcttta gggctagcct caaggtaaga gtcttggagg tagagcactg 92761 attggactag gggcccctac cgggttaccg aattcagtca aactccgaat gccaatgact 92821 tatccttggg agtcagactg cgagtgataa gatccgtagt cgaaagggaa acagcccaga 92881 ccgccagcta aggtcccaaa gtatacgtta agtggaaaag gatgtggagt tgcttagaca 92941 accaggatgt tggcttagaa gcagccacca tttaaagagt gcgtaatagc tcactggtcg 93001 agtgactctg cgccgaaaat gtaccggggc taaacgtatc accgaagctg cggactgttc 93061 ttcgaacagt ggtaggagag cgttctaagg gctgtgaagc cagaccggaa ggactggtgg 93121 agcgcttaga agtgagaatg ccggtatgag tagcgaaaga ggggtgagaa tcccctccac 93181 cgaatgccta aggtttcctg aggaaggctc gtccgctcag ggttagtcgg gacctaagcc 93241 gaggccgaaa ggcgtaggcg atggacaaca ggttgatatt cctgtaccac ctcctcacca 93301 tttgagcaat ggggggacgc aggaggatag ggtaagcgcg gtattggata tccgcgtcca 93361 agcagttagg ctgggaaata ggcaaatccg tttcccataa ggctgagctg tgatggcgag 93421 cgaaatatag tagcgaagtt cctgattcca cactgccaag aaaagcctct agcgaggtga 93481 gaggtgcccg taccgcaaac cgacacaggt aggcgaggag agaatcctaa ggtgatcgag 93541 agaactctcg ttaaggaact cggcaaaatg accccgtaac ttcgggagaa ggggtgctct 93601 gttagggtgc aagcccgaga gagccgcagt gaataggccc aggcgactgt ttagcaaaaa 93661 cacaggtctc tgcgaagccg taaggcgaag tataggggct gacgcctgcc cggtgctgga 93721 aggttaagag gagcgcttag cgtaagcgaa ggtgcgaatt gaagccccag taaacggcgg 93781 ccgtaactat aacggtccta aggtagcgaa attccttgtc gggtaagttc cgacccgcac 93841 gaaaggcgca acgatctggg cactgtctca acgagagact cggtgaaatt atagtacctg 93901 tgaagatgca ggttacccgc gacaggacgg aaagaccccg tggagcttta ctgcagcctg 93961 atattgaatg ttggtacagc ttgtacagga taggtaggag ccttggaaac cggagcgcca 94021 gcttcggtgg aggcatcggt gggatactac cctggctgta ttgaccttct aacccgccgc 94081 ccttatcggg cggggagaca gtgtcaggtg ggcagtttga ctggggcggt cgcctcctaa 94141 aaggtaacgg aggcgcccaa aggttccctc agaatggttg gaaatcattc gcagagtgta 94201 aaggcacaag ggagcttgac tgcgagacct acaagtcgag cagggacgaa agtcgggctt 94261 agtgatccgg tggttccgca tggaagggcc atcgctcaac ggataaaagc taccccgggg 94321 ataacaggct tatctccccc aagagtccac atcgacgggg aggtttggca cctcgatgtc 94381 ggctcatcgc atcctggggc tgtagtcggt cccaagggtt gggctgttcg cccattaaag 94441 cggtacgcga gctgggttca gaacgtcgtg agacagttcg gtccctatcc gtcgcgggcg 94501 caggaaattt gagaggagct gtccttagta cgagaggacc gggatggacg caccgctggt 94561 gtaccagttg ttctgccaag ggcatcgctg ggtagctatg tgcggacggg ataagtgctg 94621 aaagcatcta agcatgaagc ccccctcaag atgagatttc ccattccgca aggaagtaag 94681 atccctgaaa gatgatcagg ttgataggtc tgaggtggaa gtgtggcgac acatggagct 94741 gacagatact aatcgatcga ggacttaacc atatttttga atgatgtcac atctgttatc 94801 tagttttgag agaacactct caatttgttt ggtggcgata gcgaagaggt cacacccgtt 94861 cccataccga acacggaagt taagctcttc agcgccgatg gtagtcgggg gtttccccct 94921 gtgagagtag gacgccgcca agcaattgca cgttagtgca attatggagg attagctcag 94981 ctgggagagc atctgcctta caagcagagg gtcggcggtt cgagcccgtc atcctccacc 95041 attatgccgg tgtagctcaa ttggtagagc aactgacttg taatcagtag gttgggggtt 95101 caagtcctct tgccggcacc acttttatat gatataatac tcaagtctct tgtagaagag 95161 ccattagctc agttggtaga gcatctgact tttaatcaga gggtcgaagg ttcgagtcct 95221 tcatggctca ccattttacg cgggtgtggc ggaattggca gacgcgctag acttaggatc 95281 tagtgtcttt atgacgtggg ggttcaagtc ccttcacccg cattatatag gataacagtt 95341 agaaaaactg gacatcctgt ctgcggaagt agttcagtgg tagaacacca ccttgccaag 95401 gtgggggtcg cgggttcgaa tcccgtcttc cgctccaact ataccatcca cgccggggtg 95461 gtggaattgg cagacacaca ggacttaaaa tcctgcggta ggtgactacc gtgccggttc 95521 aagtccggcc ctcggcatta tgttttgcgc ccgtagctca attggataga gcgtttgact 95581 acggatcaaa aggttagggg ttcgactcct ctcgggcgcg ccatatcttt taatagaata 95641 gataggaaat cgggaagtag ctcagcttgg tagagcacat ggtttgggac catggggtcg 95701 caggttcgaa tcctgtcttc ccgaccattt ttttatgggg ccttagctca gctgggagag 95761 cgcctgcttt gcacgcagga ggtcagcggt tcgatcccgc taggctccac caaaagtttt 95821 taaaaaagtt gttgactttg aagaagtgac gttgtatact aataaagttg ctttaacaaa 95881 gcggacaaac aaaatgatct ttgaaaacta aacaagacaa aacgtacctg ttaattcagt 95941 ttttaaaaat cgcacagcga tgtgcgtagt cagtcaaact actttatcgg agagtttgat 96001 cctggctcag gacgaacgct ggcggcgtgc ctaatacatg caagtcgagc ggacagatgg 96061 gagcttgctc cctgatgtta gcggcggacg ggtgagtaac acgtgggtaa cctgcctgta 96121 agactgggat aactccggga aaccggggct aataccggat ggttgtttga accgcatggt 96181 tcaaacataa aaggtggctt cggctaccac ttacagatgg acccgcggcg cattagctag 96241 ttggtgaggt aacggctcac caaggcaacg atgcgtagcc gacctgagag ggtgatcggc 96301 cacactggga ctgagacacg gcccagactc ctacgggagg cagcagtagg gaatcttccg 96361 caatggacga aagtctgacg gagcaacgcc gcgtgagtga tgaaggtttt cggatcgtaa 96421 agctctgttg ttagggaaga acaagtaccg ttcgaatagg gcggtacctt gacggtacct 96481 aaccagaaag ccacggctaa ctacgtgcca gcagccgcgg taatacgtag gtggcaagcg 96541 ttgtccggaa ttattgggcg taaagggctc gcaggcggtt tcttaagtct gatgtgaaag 96601 cccccggctc aaccggggag ggtcattgga aactggggaa cttgagtgca gaagaggaga 96661 gtggaattcc acgtgtagcg gtgaaatgcg tagagatgtg gaggaacacc agtggcgaag 96721 gcgactctct ggtctgtaac tgacgctgag gagcgaaagc gtggggagcg aacaggatta 96781 gataccctgg tagtccacgc cgtaaacgat gagtgctaag tgttaggggg tttccgcccc 96841 ttagtgctgc agctaacgca ttaagcactc cgcctgggga gtacggtcgc aagactgaaa 96901 ctcaaaggaa ttgacggggg cccgcacaag cggtggagca tgtggtttaa ttcgaagcaa 96961 cgcgaagaac cttaccaggt cttgacatcc tctgacaatc ctagagatag gacgtcccct 97021 tcgggggcag agtgacaggt ggtgcatggt tgtcgtcagc tcgtgtcgtg agatgttggg 97081 ttaagtcccg caacgagcgc aacccttgat cttagttgcc agcattcagt tgggcactct 97141 aaggtgactg ccggtgacaa accggaggaa ggtggggatg acgtcaaatc atcatgcccc 97201 ttatgacctg ggctacacac gtgctacaat ggacagaaca aagggcagcg aaaccgcgag 97261 gttaagccaa tcccacaaat ctgttctcag ttcggatcgc agtctgcaac tcgactgcgt 97321 gaagctggaa tcgctagtaa tcgcggatca gcatgccgcg gtgaatacgt tcccgggcct 97381 tgtacacacc gcccgtcaca ccacgagagt ttgtaacacc cgaagtcggt gaggtaacct 97441 tttaggagcc agccgccgaa ggtgggacag atgattgggg tgaagtcgta acaaggtagc 97501 cgtatcggaa ggtgcggctg gatcacctcc tttctaagga tattttacgg aatataagac 97561 cttgggtctt ataaacagaa cgttccctgt cttgtttagt tttgaaggat cattccttcg 97621 aaacgtgttc tttgaaaact agataacagt agacatcaca ttcaagtaat acaagatatc 97681 acatagtgat tctttttaac ggttaagtta gaaagggcgc acggtggatg ccttggcact 97741 aggagccgat gaaggacggg acgaacaccg atatgcttcg gggagctgta agcaagcttt 97801 gatccggaga tttccgaatg gggaaaccca ccactcgtaa tggagtggta tccatatctg 97861 aattcatagg atatgagaag gcagacccgg ggaactgaaa catctaagta cccggaggaa 97921 gagaaagcaa atgcgattcc ctgagtagcg gcgagcgaaa cgggatcagc ccaaaccaag 97981 aggcttgcct cttggggttg taggacactc tgtacggagt tacaaaggaa cgaggtagat 98041 gaagaggtct ggaaaggccc gccataggag gtaacagccc tgtagtcaaa acttcgttct 98101 ctcctgagtg gatcctgagt acggcggaac acgtgaaatt ccgtcggaat ccgggaggac 98161 catctcccaa ggctaaatac tccctagtga ccgatagtga accagtaccg tgagggaaag 98221 gtgaaaagca ccccggaagg ggagtgaaag agatcctgaa accgtgtgcc tacaagtagt 98281 cagagcccgt taacgggtga tggcgtgcct tttgtagaat gaaccggcga gttacgatcc 98341 cgtgcaaggt taagcagaag atgcggagcc gcagcgaaag cgagtctgaa tagggcgcat 98401 gagtacgtgg tcgtagaccc gaaaccaggt gatctaccca tgtccagggt gaagttcagg 98461 taacactgaa tggaggcccg aacccacgca cgttgaaaag tgcggggatg aggtgtgggt 98521 aggggtgaaa tgccaatcga acctggagat agctggttct ctccgaaata gctttagggc 98581 tagcctcaag gtaagagtct tggaggtaga gcactgattg gactaggggc ccctaccggg 98641 ttaccgaatt cagtcaaact ccgaatgcca atgacttatc cttgggagtc agactgcgag 98701 tgataagatc cgtagtcgaa agggaaacag cccagaccgc cagctaaggt cccaaagtat 98761 acgttaagtg gaaaaggatg tggagttgct tagacaacca ggatgttggc ttagaagcag 98821 ccaccattta aagagtgcgt aatagctcac tggtcgagtg actctgcgcc gaaaatgtac 98881 cggggctaaa cgtatcaccg aagctgcgga ctgttcttcg aacagtggta ggagagcgtt 98941 ctaagggctg tgaagccaga ccggaaggac tggtggagcg cttagaagtg agaatgccgg 99001 tatgagtagc gaaagagggg tgagaatccc ctccaccgaa tgcctaaggt ttcctgagga 99061 aggctcgtcc gctcagggtt agtcgggacc taagccgagg ccgaaaggcg taggcgatgg 99121 acaacaggtt gatattcctg taccacctcc tcaccatttg agcaatgggg ggacgcagga 99181 ggatagggta agcgcggtat tggatatccg cgtccaagca gttaggctgg gaaataggca 99241 aatccgtttc ccataaggct gagctgtgat ggcgagcgaa atatagtagc gaagttcctg 99301 attccacact gccaagaaaa gcctctagcg aggtgagagg tgcccgtacc gcaaaccgac 99361 acaggtaggc gaggagagaa tcctaaggtg atcgagagaa ctctcgttaa ggaactcggc 99421 aaaatgaccc cgtaacttcg ggagaagggg tgctctgtta gggtgcaagc ccgagagagc 99481 cgcagtgaat aggcccaggc gactgtttag caaaaacaca ggtctctgcg aagccgtaag 99541 gcgaagtata ggggctgacg cctgcccggt gctggaaggt taagaggagc gcttagcgta 99601 agcgaaggtg cgaattgaag ccccagtaaa cggcggccgt aactataacg gtcctaaggt 99661 agcgaaattc cttgtcgggt aagttccgac ccgcacgaaa ggcgcaacga tctgggcact 99721 gtctcaacga gagactcggt gaaattatag tacctgtgaa gatgcaggtt acccgcgaca 99781 ggacggaaag accccgtgga gctttactgc agcctgatat tgaatgttgg tacagcttgt 99841 acaggatagg taggagcctt ggaaaccgga gcgccagctt tggtggaggc atcggtggga 99901 tactaccctg gctgtattga ccttctaacc cgccgccctt atcgggcggg gagacagtgt 99961 caggtgggca gtttgactgg ggcggtcgcc tcctaaaagg taacggaggc gcccaaaggt 100021 tccctcagaa tggttggaaa tcattcgcag agtgtaaagg cacaagggag cttgactgcg 100081 agacctacaa gtcgagcagg gacgaaagtc gggcttagtg atccggtggt tccgcatgga 100141 agggccatcg ctcaacggat aaaagctacc ccggggataa caggcttatc tcccccaaga 100201 gtccacatcg acggggaggt ttggcacctc gatgtcggct catcgcatcc tggggctgta 100261 gtcggtccca agggttgggc tgttcgccca ttaaagcggt acgcgagctg ggttcagaac 100321 gtcgtgagac agttcggtcc ctatccgtcg cgggcgcagg aaatttgaga ggagctgtcc 100381 ttagtacgag aggaccggga tggacgcacc gctggtgtac cagttgttct gccaagggca 100441 tcgctgggta gctatgtgcg gacgggataa gtgctgaaag catctaagca tgaagccccc 100501 ctcaagatga gatttcccat tccgcaagga agtaagatcc ctgaaagatg atcaggttga 100561 taggtctgag gtggaagtgt ggcgacacat ggagctgaca gatactaatc gatcgaggac 100621 ttaaccatat ttttgaatga tgtcacatct gttatctagt tttgagagaa cactctcaat 100681 ttgtttggtg gcgatagcga agaggtcaca cccgttccca taccgaacac ggaagttaag 100741 ctcttcagcg ccgatggtag tcgggggttt ccccctgtga gagtaggacg ccgccaagca 100801 agcttaaacc cagctcaatg agctgggttt tttgtatttt ggtttattgg tatcataaaa 100861 ttccacttaa ctgtataata taataacttt ataccgaatt ttaaatcagc aatcaggttt 100921 tgtggaccgg gaaaatggaa ataatgaagg atagagcgag aaagttgaaa attctcgaga 100981 aacggcttat agtaagatta aagtcaaata tagtcaaagt cagtaaagga gggggttgag 101041 tgggacataa tatttctgac atcattgaac aatatttaaa acgagtgtta gatcaaaatg 101101 gcaaggaaat tttagagatt aaacgaagtg aaattgcaga taaatttcaa tgcgttcctt 101161 cccaaataaa ttatgtcatc aacaccagat ttacaagcga aagaggatat attgttgaga 101221 gcaaacgcgg gggcggcggt tacatcagaa tcattaaaat taaaatgaac aatgaagttg 101281 tcctgatcaa taatataatt tctcaaatta atacccattt gtctcaagca gcctctgatg 101341 acattatttt aaggctatta gaagacaagg taatttcaga aagagaagca aaaatgatgg 101401 tcagcgtaat ggaccgctca gttttacaca ttgacttacc tgaacgtgat gaattaagag 101461 cgagaatgat gaaggcaatg ctgacttctt taaaattaaa ataagcgggt gaaaagattg 101521 atttgtcaag agtgccacga gagaccagcc acttttcact ttacaaaggt tgttaacgga 101581 gaaaaaatag aagttcatat ttgtgaacaa tgtgccaaag aaaatagtga ttcatatggt 101641 ataagtgcaa atcagggttt ctctattcat aatttacttt cgggtttact gaacatggat 101701 tcttcatttc aaaatgcagg aactcaaatg ttcagtcact cggagcaaat atctgcttgt 101761 ccgaaatgcg gaatgacttt tcagcaattc agaaaaattg gccgttttgg atgttctgaa 101821 tgttacaaaa catttcatag caacattaca ccaatcctac gtaaagtgca cagcggaaac 101881 actgtgcatg caggtaagat accgaaacga ataggcggca atcttcatgt cagacggcag 101941 attgatatgc taaaaaagga attagaatcc ttaatccatc aagaagaatt tgaaaatgca 102001 gctcatgtaa gagatcaaat tcgtttatta gaacaatcac tcaaaagtac agatagtgag 102061 gaggaacagg agtaatgtcg ctaaagcatt ttattcagga cgcactaagc agttggatga 102121 agcagaaagg acctgaaagt gacattgtac tcagcagccg catacgttta gcaagaaact 102181 ttgagcatat tcggttccct acgcggtatt ccaatgaaga agcctcatcc atcatacagc 102241 aatttgaaga tcagttttca gagcaagaaa ttcccggaat cggcaaattt gttttgatta 102301 gaatgaatga tgcacagcct ttagaaaagc gtgtacttgt tgaaaaacat ctaatcagcc 102361 cgaatttgac agagtctcct tttggcggct gtttgctttc tgaaaatgag gaagtaagcg 102421 tcatgctaaa tgaagaggac catattagaa ttcagtgtct tttccctgga tttcagcttt 102481 tagaagcaat gaaagccgca aaccaggtcg acgactggat tgaagaaaaa gttgattatg 102541 cattcaatga gcaaagagga tacttaacca gctgtcctac aaacgtaggt actggtttaa 102601 gggcttcggt catgatgcat ctgccggcgc tggttttaac taggcaaata aatcgaatta 102661 taccggcaat taatcaatta ggcttagttg ttagaggaat ttatggggaa ggcagcgaag 102721 cagtagggaa tatctttcaa atttcaaatc agatcacgct tggtaagtca gagcaggata 102781 ttgtagagga tcttaacagt gttgctgctc agttgattga acaagaacga tctgcccgag 102841 aagcgattta tcaaacttct aaaatcgaac ttgaggatcg ggtatatcgg tcatatgggg 102901 tcttgtctaa ttgccggatg atagaatcga aagaaactgc aaagtgcctt tcagatgttc 102961 ggttaggcat agacttaggc ataataaaag gactttcaag caacatactt aacgaactta 103021 tgattttgac gcagccaggg tttttacagc aatactcggg aggcgctttg cgaccgaacg 103081 aaagggacat tcgaagagcg gctctcatca gagaacggct tcacttagaa atgaatggga 103141 aaagacagga ggatgaatcg atatgatgtt tggaagattt acagaacgag ctcaaaaagt 103201 actggcgcta gcacaggaag aagcacttcg gttaggtcat aataacattg gcactgagca 103261 tattttatta ggactggtaa gagaaggaga gggcattgct gctaaagctc ttcaagcgct 103321 tggactcggt tcagaaaaaa ttcagaaaga agtagaaagt ttgatcgggc gcgggcagga 103381 aatgtctcaa acgattcatt atactcctag agctaaaaaa gtcattgagc tttcaatgga 103441 tgaggcaaga aaactcggtc attcttatgt gggaacagaa catattcttc ttggtctgat 103501 tcgtgaagga gaaggtgttg ctgcgagagt tctgaataat ctcggtgtca gcttaaataa 103561 agcaagacag caggtgctcc agcttctagg aagtaatgaa acaggatcat cagcggcagg 103621 aacaaacagc aatgcgaata cgcctacgct tgacagcttg gcaagagact taactgctat 103681 tgcgaaggaa gacagccttg accctgtaat cggcagaagc aaggagatcc agcgtgtcat 103741 tgaagtgtta agccgcagaa cgaaaaacaa ccctgttctc attggggaac caggtgtagg 103801 taaaacggct atcgcagaag gtttggcaca gcaaattatc aataatgaag tacccgaaat 103861 tttgcgtgat aaacgtgtga tgacattaga catgggaaca gttgttgccg gcacaaaata 103921 ccgcggagaa tttgaggatc gcctgaagaa ggtcatggat gaaattcgcc aggcaggaaa 103981 tatcattcta ttcatcgatg agctccatac attaatcggg gcaggcggag cagaaggtgc 104041 tattgatgca tctaatattt taaaaccttc acttgctcgt ggcgaactcc aatgtattgg 104101 tgcaacgact cttgatgagt accgtaaata tattgaaaaa gatgcagcac tggaacgccg 104161 ttttcagccg attcaggttg atcagccatc tgtagatgaa agtattcaaa ttttacaagg 104221 tctgcgtgac agatacgaag cccaccaccg cgtttctatc actgatgatg ccattgaagc 104281 tgcggttaag ctttctgaca gatatatttc tgaccgcttc cttccggata aagcaattga 104341 cttgatcgat gaagcgggtt caaaggtgag actgcgctca tttacaacgc ctcctaactt 104401 aaaagagctt gagcagaagc ttgatgaggt tcgtaaagag aaggatgcgg cagtgcaaag 104461 ccaagagttt gaaaaagctg cttccttgcg tgatactgaa caacgcctgc gcgagcaagt 104521 agaggatacg aagaaatcat ggaaagagaa gcaagggcag gaaaactcag aggttactgt 104581 ggatgatatt gcgatggttg tatccagctg gaccggtgtg cctgtatcta aaatcgccca 104641 aactgaaact gataagcttc tcaatatgga aaacattctt cactcccgtg tcatcggcca 104701 ggatgaagca gttgtagcgg ttgcaaaagc cgtcagacgt gcaagagcag gattgaaaga 104761 tcctaaacgc ccaatcggct cattcatttt cttaggccct acaggtgtag gtaaaacaga 104821 acttgcacga gcacttgctg aatccatttt tggcgatgaa gaatccatga tcagaattga 104881 tatgtctgaa tacatggaaa aacattcaac ttcaagactt gttggttcac ctccgggtta 104941 tgtgggatat gatgaaggcg gtcaattgac agagaaagtc agaagaaaac cttactctgt 105001 cgtgcttctt gatgagatcg agaaagcgca ccctgatgtc ttcaatatcc ttctgcaagt 105061 tcttgaagac ggacgattga ctgattctaa aggacgcaca gtcgatttcc gcaataccat 105121 tctgatcatg acatcaaacg tcggagcaag tgagctaaaa cgcaataaat atgtcggctt 105181 taacgttcag gatgaaactc aaaatcataa agacatgaaa gataaagtga tgggtgaatt 105241 aaaacgagcg ttcagacctg agttcatcaa ccgtattgat gaaatcattg tcttccattc 105301 acttgagaaa aaacatctca ctgagattgt gtcattaatg tctgatcaat taacgaaacg 105361 cctgaaagaa caagatcttt ctatcgaatt gacagatgct gcaaaagcga aagtcgcgga 105421 agagggcgtt gacctggaat acggtgcccg tccgttaaga agagcgatcc aaaaacatgt 105481 cgaggatcgt ttatctgaag aactcctcag aggaaatatt cataaaggac agcatattgt 105541 tcttgatgta gaagatggcg aatttgtcgt aaaaacgact gctaaaacga attaatatag 105601 aagacggaaa tgaggcatac agcatgtaag tgtatgcctc actttcatat caagaaatag 105661 aacaagggag aggtcttaca ctatatatgg ctaaaacaaa atcgaagttc atctgccaat 105721 cctgcggcta cgagtctcca aaatggatgg ggaaatgtcc gggctgtggt gcttggaata 105781 caatggtgga agaaatgatt aaaaaagcac cggccaatcg gagagcggct ttttctcatt 105841 ctgttcaaac tgtacagaaa ccttcaccta ttacatcaat cgaaacatca gaagaacccc 105901 gcgtcaaaac ccagcttggc gagtttaaca gagtactcgg cggaggtgtc gttaaaggct 105961 ccctcgtttt aattggcggt gatcctggta tcggaaagtc aacgctatta ctgcaggttt 106021 ccgctcaatt atcaggctca tcaaacagtg tcctgtatat ttcgggagaa gaatctgtaa 106081 agcaaacgaa gctgcgagca gaccgtctcg gcattaataa tccgtcactg catgttttat 106141 ctgaaaccga tatggagtat atttcgtctg ctatacaaga gatgaatcca tcgtttgtcg 106201 ttgttgactc tattcaaacg gtttaccaaa gcgatattac atctgctcca ggcagtgtgt 106261 cacaggtcag agaatgtacc gctgagctga tgaaaattgc aaaaacaaaa ggtattccga 106321 tttttatcgt agggcacgtg acgaaagaag ggtctattgc aggtccgaga ctgttggagc 106381 atatggttga cactgtttta tattttgaag gagaacgcca ccatactttc cgtattttgc 106441 gggctgtaaa aaaccgtttc ggatctacaa acgaaatggg cattttcgaa atgcgggaag 106501 aggggctcac tgaggttttg aatccttcgg aaattttctt agaagaacgc tctgctggtt 106561 ccgcaggctc gagtatcact gcctctatgg agggcactag accgattctc gttgaaattc 106621 aggcactcat ctcgccaaca agttttggca acccaaggcg tatggcaacg ggaatagacc 106681 ataacagggt ttctctgtta atggctgtgt tagaaaaaag agttggactg ctgctgcaaa 106741 atcaggatgc ttatttgaaa gtggctggcg gcgttaagct tgatgaaccg gcaattgatc 106801 ttgcgattgt gattagtatt gcatcaagct ttagagacac acctccaaat cctgcagatt 106861 gttttattgg agaagtggga ttaaccggag aagtccggcg ggtttcaaga attgaacagc 106921 gtgtgaaaga agcggcaaag cttggtttta aacgcatgat catacccgcg gcaaatctgg 106981 atggatggac aaaaccaaaa gggattgagg ttatcggagt agcaaatgtt gcagaagcgc 107041 ttcgtacttc attaggagga taatagatgg aaaaagagaa aaaaggggcg aaacacgagt 107101 tagacctgtc atctatattg cagtttgttg ctccgggtac accgctcaga gcggggatgg 107161 aaaacgtctt gagagcaaat acaggcggtc tgattgttgt tggatataat gataaagtaa 107221 aagaagtggt ggacggcggc tttcacataa acacggcttt ttctccggcg catttatatg 107281 agctggctaa aatggatgga gcgatcattt taagtgattc tggtcaaaag atcctatacg 107341 cgaatactca gctgatgccg gatgccacaa tttcttcatc agaaacagga atgcggcaca 107401 gaactgccga aagagtagct aagcaaactg gctgtcttgt aatcgccatt tctgaaagaa 107461 gaaatgtcat aacgttatat caggaaaaca tgaagtatac actaaaagac ataggattta 107521 ttttaaccaa ggcgaaccaa gccattcaaa cacttgaaaa atataagaca atcctcgata 107581 aaacgattaa tgcactgaac gcgttagagt ttgaggaact tgttaccttc agtgatgtct 107641 tgtctgtcat gcatcgttat gaaatggtac tgagaatcaa aaacgaaatt aatatgtata 107701 tcaaagagct ggggacagaa gggcatctga tcaaactgca agtcattgaa ttgattacgg 107761 atatggaaga agaggccgct ttatttatta aggactatgt aaaagaaaag attaaagatc 107821 cgtttgttct cttgaaggag ctgcaggata tgtccagtta tgatctgctg gatgattcca 107881 ttgtgtataa gcttctcggt taccctgctt ctactaatct tgatgattat gtattgccga 107941 gaggatacag gctgttaaat aagataccgc gtcttccgat gccgattgtt gaaaatgttg 108001 tagaagcatt tggagtcctg ccaaggatta ttgaggcgag tgcagaagaa ttagatgaag 108061 tagagggaat cggtgaagta cgagcccaaa aaatcaaaaa aggattaaaa cgcctgcaag 108121 agaagcatta tttagacaga caactgtgat ttcggttaaa accttatgaa tacgggtata 108181 ttaatgttgg tttttgttta ttctgatatt cgtaggatgc ataagacttt gtgaaattaa 108241 aatgttaaaa aaggaggtgg gggtatgtta aaacgaatag ttcaggcgtt cttcattatt 108301 tttggcggcg ttgttggtat atttttgata cctgaattgt ttgtactgtt aaatatacag 108361 gacatacctt taataacaaa cgcatatacg tctgcggcaa taggagcaat tatctttttt 108421 ctcatcagta tatggggtac agaatacgtt gtgaactggg tgaagtggat agaggattca 108481 ttgttaaaag cgccggttcc agatttgtta tttggaagtc ttggcttagt ttttggactt 108541 ataattgctt atcttatcgt aaatgttatt cctttagaca atatacctta ccgcatattc 108601 agcacaataa ttcctgtatt tttggctttc ttcctcggtt atctcggctt ccaggtgggc 108661 tttaagaaaa aggatgaatt gatcagcctg ttttccattt ccgccagaat gcaaaagaaa 108721 aaaggaacag ctgatgaaga acatgaggtt caagacaaga agctgaaaat tttggacact 108781 agtgttatta ttgatgggag aatagcagat atttgtcaga ctggtttttt agagggagtt 108841 atcgtgattc cgcagtttgt ccttgaggaa ttgcagcata ttgcagactc ttcagatgtt 108901 ttaaaacgaa acagaggacg ccgcggtctt gatatcctga accgcattca gaaagaatta 108961 gacattgaag ttgaaattta cgaaggcgac tttgaagata ttcaggaggt tgacagcaag 109021 ctcgtcaaac ttgctaagct gacatccggg gtcgttgtga cgaatgattt taatttaaat 109081 aaagtgtgcg agcttcagaa ggtagcagta ttaaacatta atgaccttgc caatgcggtt 109141 aagcctgttg tgcttcctgg cgaggaaatg aatgttcagg tcattaagga cgggaaagag 109201 cataatcagg gagttgccta cttggatgac ggtacgatga ttgtcgttga agaaggacgg 109261 aattatatcg gcaagcatat tgatgtactc gtcacaagtg tgctgcagac agcagcggga 109321 cgaatgattt ttgcgaagcc taagctgttg gagaaggcgc tgtaaaggga gaagaaacaa 109381 tgagttatga tgtggtgatt cctgcagccg gacagggaaa gcggatgaag gcagggagaa 109441 ataaactgtt cattgagctg aagggagacc cggtgatcat acacacgtta agagtgtttg 109501 acagccaccg gcagtgcgat aaaatcattt tggtgattaa cgagcaggag cgggagcact 109561 ttcagcaatt gctgtccgat tacccgtttc aaacttcaat tgagcttgtt gcaggcggag 109621 atgagcgaca gcacagtgtg tataaggggc tgaaagccgt aaagcaggaa aagattgtcc 109681 ttgtacatga cggtgcccgt ccatttataa aacatgaaca aattgacgaa ctgatcgcag 109741 aggcggaaca gacaggagcg gccatccttg ctgttccggt aaaagatacg attaaacgcg 109801 ttcaagattt acaagtcagt gagacgattg aacgttcaag cttgtgggct gtccaaacgc 109861 cacaagcttt tcgtctttct ttattgatga aggctcacgc tgaggccgag cgcaagggat 109921 ttttagggac ggatgacgcc agcctcgttg aacagatgga gggcggttcg gtccgtgttg 109981 tagaaggcag ctatacaaat attaagctga cgacgccaga cgatttgacg tcagctgaag 110041 ctatcatgga atcagaaagt gggaataaac atgtttagaa ttggacaagg atttgatgtg 110101 catcaattag tggagggccg tcctctcatt attggcggaa ttgaaatccc gtacgaaaaa 110161 gggctgcttg gccattctga tgcagacgta ttgttgcata ccgtcgctga cgcctgcctg 110221 ggagctgtgg gtgaaggaga cataggcaag cattttcctg acacagatcc cgagttcaag 110281 gacgcagatt ctttcaaatt acttcagcat gtctggggaa tcgtgaaaca gaaggggtat 110341 gtccttggga acattgattg caccatcata gcgcaaaagc cgaagatgct gccgtacata 110401 gaagatatga gaaaaagaat tgctgaaggc cttgaggcag atgtttctca agtaaatgta 110461 aaagcaacaa cgacagaaaa gcttggattt acaggccggg cggaaggaat agcggctcag 110521 gcgacagtac tgatacaaaa aggctaactt gttttgatgc cgggtctatt tggtggtaga 110581 atagattcat acatttttgc ctgaggccat acatgacatg aaaggaagta tttgaaaatg 110641 ggaaacgaag tacgcgtccg ttatgcaccg agtccaaccg gacatttgca tattggaaat 110701 gccagaacgg cgctttttaa ttatttattt gcccgcaatc aaggcggtaa gtttatcatt 110761 cgagttgagg atactgataa aaagcgcaat attgagggcg gagaacaaag ccagctgaat 110821 tatctgaagt ggctaggtat tgactgggat gagagtgtgg atgtcggagg agagtacggt 110881 ccataccgtc agtcagagcg taacgatatc tataaagtgt actatgaaga gcttcttgaa 110941 aaagggcttg cttataaatg ttactgtacg gaagaagagc ttgaaaaaga gcgtgaagaa 111001 cagattgccc gcggagaaat gcctcgttat tccggaaaac acagagacct gactcaggaa 111061 gaacaggaga aatttatcgc cgaaggcaga aaaccaagta ttcgtttccg tgtgccggaa 111121 ggaaaagtca tcgccttcaa cgacatcgta aaaggcgaaa tttcttttga atcagatggc 111181 atcggcgact tcgttattgt gaaaaaggac ggaacgccta cttataactt cgcggtagct 111241 attgatgact acttaatgaa aatgacacac gtgctgcgcg gtgaggatca tatttctaac 111301 acaccgaaac agattatgat ctatcaagca ttcgggtggg atattcctca gttcggacac 111361 atgacgctga ttgtaaacga aagccgtaaa aagctcagca aacgtgatga atccattatt 111421 caattcatcg agcagtacaa agagcttggc tacctgccag aagcgctgtt caactttatc 111481 ggcttgttag gctggtcacc ggttggagaa gaagagcttt tcacaaaaga gcagtttatt 111541 gaaatttttg atgtaaatcg tttatctaaa tcaccagctt tgtttgatat gcataagcta 111601 aaatgggtta acaaccaata tgtgaagaag ctggatcttg atcaggttgt tgaactgacg 111661 cttccgcatt tgcaaaaagc cggcaaagtt ggcactgagc tttctgctga agaacaagaa 111721 tgggttcgta aactgatttc cctgtatcat gagcaattaa gctacggtgc ggaaattgtt 111781 gagctgactg atttgttctt tacggatgag atcgagtata atcaagaagc gaaagctgtt 111841 ctggaagaag aacaggttcc tgaagtgctc agcacattcg cagcgaagct tgaagagctt 111901 gaggagttca ctccggataa tatcaaagca tcgatcaaag cagtgcagaa agaaactggc 111961 cataaaggga aaaaactgtt tatgccgatt cgtgttgctg taacagggca aactcacggt 112021 ccggaactgc cgcaatcaat tgaattgatc ggtaaagaga ctgcaattca gcgtttaaag 112081 aatatctaaa taaatgattg ttgacaggga agagtataaa gctttaggcc attacagaaa 112141 ggatcttcat tggctgagag agatccatga gccgggtttt agaagtgcgc ccttaagacc 112201 tttgaagaac gttttttgaa atcagtattc aaaggcggcc gccgccgtta caggctgaag 112261 ttgggagagc agaagtctgc ttttcaaaca gagtggaacc gcgcggttaa agcgtctctg 112321 tcatgtttac atgcagagac gcttttttta ttgggtagag gaaatcagat agagaaacgg 112381 ggggaagcat gtgtttttta gaatgctcaa agaagacatt gatactgtgt tcgatcaaga 112441 tcccgcagca agaagctatt ttgaagtgat tttaacttat tccggtttac atgctatatg 112501 ggcgcatcgg attgcacatg ctttatataa acgaaaattt tatttccttg cacgccttat 112561 atctcaagta agccgatttt ttaccgggat agaaatccac cccggcgcta caatcgggag 112621 aagatttttc atagaccacg gcatgggggt tgtcattggg gagacatgtg aaatcggcaa 112681 taacgtaacc gtttttcagg gggttaccct cgggggaacg ggaaaagaaa agggaaaaag 112741 gcacccaacg attaaagatg acgcattgat agccacaggt gctaaagtgc tcggttctat 112801 tacggtcggt gaaggctcaa agattggcgc tggttcagta gtgctgcatg atgttcctga 112861 tttttcaaca gttgtcggta tccctggacg ggtcgttgta caaaatggca agaaagtaag 112921 acgcgattta aaccatcagg atttgcccga tccagttgct gaccgcttta agtctttgga 112981 acagcagatt ttagagctga aggcagaact tgaagacaga aaagaaagga tcaatcaaaa 113041 atgacaatca cactttataa tacattgact agacagaagg aaacattcgt tcctcttgaa 113101 gagggaaaag tgaaaatgta tgtatgcgga cccacggttt acaattacat tcatatcggg 113161 aacgcgcgtc cggcaatcgt ttacgatacg gttcgaaact atttagagta taaaggctat 113221 gatgtgcagt atgtctctaa cttcacagac gtagacgata aattaattaa agcggcaaat 113281 gaactcggtg aggatgtacc caccatttca gagcgtttta ttaaagcata ctttgaagac 113341 gtaggtgcgc tcggctgccg aaaagccgac cttcatccgc gagtaatgga gaacatggat 113401 gccattatcg aattcgtaga tcagctcgtg aaaaagggct acgcatatga atcagaaggt 113461 gacgtatatt tcaaaaccag agcatttgaa gggtacggaa agctttctca gcaatcaatc 113521 gatgaactaa gatcaggtgc acgcatccgg gtcggcgaga aaaaagaaga tgctcttgat 113581 ttcgcactgt ggaaagcggc aaaagaagga gaaatctctt gggatagccc ttgggggaaa 113641 gggcgtccgg gctggcacat tgaatgctca gcaatggtga aaaagtatct cggtgaccag 113701 attgatatcc atgcgggcgg acaggattta acattccctc accatgaaaa cgaaattgcg 113761 caatctgagg cgctgacagg caaaacgttt gcgaagtact ggcttcataa tggttatatc 113821 aatattgata atgaaaaaat gtcaaaatca ctaggcaact ttgtgcttgt gcatgacatc 113881 attaaacagc atgatccgca gcttttgaga ttctttatgc tatctgttca ttatcgccat 113941 ccgattaact attcagaaga gcttctggag aatacgaaaa gcgcgttcag ccgtttaaaa 114001 acagcgtaca gcaatcttca gcaccgtctg aacagcagta cgaatttaac cgaagatgac 114061 gatcaatggc ttgaaaaggt tgaagaacac cgcaaagcat tcgaagaaga gatggacgat 114121 gattttaata cggcgaatgc catttcagtc ttgtttgact tagcgaaaca cgccaattat 114181 tatcttcaga aagatcatac ggctgatcat gtgattacgg cgtttattga gatgtttgac 114241 cgcattgttt ctgtcctcgg tttttcgttg ggtgagcagg aacttctcga tcaagagatt 114301 gaagacttaa tcgaaaagcg aaatgaagcg cgccggaatc gcgattttgc attgtcagac 114361 cagatccgcg accagctgaa aagcatgaat atcattcttg aagatacggc tcaaggcact 114421 cgctggaaac ggggagaata acagatgctt gaatttgata cgataaaaga ttctaagcag 114481 cttaacggtc ttgcgcttgc ttatataggt gatgccattt ttgaagtgta tgtcaggcat 114541 cacctgctta agcagggctt taccaaacca aatgatcttc ataagaaatc aagccggatt 114601 gtttcagcaa agtcacaggc tgagatccta ttttttctgc agaatcaatc attttttacg 114661 gaagaagagg aagcggtgct gaaaagaggc agaaatgcca agtcagggac aacacctaaa 114721 aatacagatg ttcagacgta ccgctacagt acagcatttg aagcgcttct gggctacctt 114781 tttctagaga aaaaagagga acgacttagt cagctcgtag ccgaagctat acaattcggg 114841 acgtcaggga ggaaaacaaa tgagtcagca acatgattac gtcataggga aaaatgcagt 114901 gatcgagacg ttaaaatctg atcggaagct gtataagctg tggatggcgg aaaacaccgt 114961 aaagggacaa gcacagcaag tgattgagct tgccaaaaag cagggaatca cgattcaata 115021 cgtcccgaga aaaaaactcg atcaaatggt gacaggacag catcagggcg tagtggcaca 115081 ggttgcagcg tatgaatatg cagaactgga cgatttatat aaagcagccg aagaaaaaaa 115141 tgaacagcct ttcttcctca ttctggacga gcttgaagac cctcataatc ttggttccat 115201 tatgaggaca gcagatgcgg tcggcgctca tggcatcgtc attccaaaac ggagagctgt 115261 cgggctgaca acaacagtgg caaaagcttc aacaggagca attgagcaca ttcctgtagc 115321 aagagtcacc aatttggcac ggacgttaga agagatgaaa gagcggggaa tctgggttgt 115381 cggaacggat gcgtccgcgc gtgaggattt ccgtaatatg gacggcaata tgcctttggc 115441 tctagtcatc ggaagtgaag gaaaagggat gggccgcctt gtgaaggaaa agtgcgattt 115501 tctcattaaa ctcccgatgg ccggaaaggt aacttcacta aatgcatctg tcgcggctgg 115561 tcttttgatg tatgaagtct accggaaacg aaaccctgtg ggagaataaa gacccatgga 115621 tatcctgtta gtagacgggt acaacatgat tggagcctgg ccgcagctga aggatttaaa 115681 agcgaacagt tttgaagagg cgagagacgt actgattcag aaaatggcgg aatatcaatc 115741 gtatacagga aacagggtta ttgttgtttt tgacgcgcat ctcgtaaaag ggcttgagaa 115801 aaaacagacc aaccatagag ttgaagtaat ttttacaaaa gaaaatgaga cggctgatga 115861 gcggatagaa aagctcgctc aggctttgaa taatattgcg actcaaattc acgttgcgac 115921 ctctgactat actgagcagt gggcgatttt cggacagggg gcattgcgga aatcggcccg 115981 ggagcttctg agagaggtag aaacgattga aaggcgaata gagagacggg taagaaaaat 116041 cacttccgaa aagccggcgg gtaaaattgc tttatcggaa gaggttttga aaacgtttga 116101 aaagtggagg cggggagact tagattaagt tgacgctttt ttgcccaata ctgtataata 116161 tttctatcta cgtgcgccgg ggggatcgga gtgaatctac agaacaacaa gggaaaattc 116221 aacaaagagc agttttgcca gttggaggac gagcaggtca ttgaaaaggt tcatgttggg 116281 gacagtgatg cgttagatta cttgattacg aagtaccgaa actttgttcg ggcaaaagca 116341 agatcctatt tcttaatagg ggcggacaga gaggatattg ttcaggaagg catgataggc 116401 ctctataagt ctattcgtga cttcaaagag gacaagctta cctcattcaa agcttttgca 116461 gaattatgta ttacccgcca aattattacc gcaataaaga cagctactcg ccagaaacac 116521 attcctttga attcctacgc ctcattagat aaaccgatct ttgatgaaga atcagaccga 116581 acgctgctgg atgtcatttc aggagcgaaa accttaaatc ctgaggaaat gatcattaat 116641 caggaagaat ttgatgatat tgaaatgaaa atgggagaac tattaagtga tttagagaga 116701 aaagtactcg tcttatatct cgacgggaga agttaccaag agatttctga tgaactgaac 116761 cgacatgtga aatcgatcga caatgccctt cagcgtgtga aacgcaagct ggagaagtac 116821 ttggaaattc gcgaaatcag tttgtaatag gaatttatgc tatattgaca gtatttttct 116881 gactatgata tgttactaaa gataagaact aatgtctatt tagaaaaagg tgtaatgaca 116941 tgagaaaaaa gattacgtta gcatgcaaga catgcggaaa ccgtaattat acgacaatga 117001 agagctctgc atcagcggct gagcgattag aagtaaagaa atactgcagt acttgcaatt 117061 cacatacagc tcatcttgaa acaaaatagt ttttgcgctt ttaaattgtg gaggtctttt 117121 acatgcgtat tatgaaattc tttaaagatg ttgggaaaga aatgaaaaag gtaagctggc 117181 ctaaaggaaa agagttaacg cgttatacca ttacggtaat ttcaacagtt atcttttttg 117241 ttatcttttt tgccctcctt gacacaggaa tttctcaatt aattcgttta atagttgaat 117301 aatgatcagc aatacgtgct ataatagatc ataatattac ttgccaaaac ccgttcagcg 117361 ggttttttat tgtggcttaa aatgaaagtt atcataggct tgccgcctat tttttgaagc 117421 gttatggtaa ttcactaaaa ccaaatgcgg ggagggaagg actggacagt cctgaataga 117481 atggaaaaga attggtatgt tgttcacacg tactctggtt atgagaataa agtaaaagcc 117541 aacttggaaa agcgtgttga atcaatgggg atgcaggata aaattttccg tgtagtcgta 117601 cccgaagaag aagaaacgga tatcaaaaac ggcaagaaaa aagtcgtgaa aaagaaagta 117661 ttccctggtt atgtgcttgt tgaaattgta atgacagacg actcttggta tgtcgtccgc 117721 aacacgccgg gcgttactgg attcgtagga tctgccgggt caggttcaaa accgacgccg 117781 cttcttccgg gggaagcaga aaccattctg aagagaatgg gcatggatga acgaaaaact 117841 gatattgact ttgaactgaa agagacagtg aaagtaatag acggaccttt tgctaacttt 117901 acaggatcaa ttgaagagat tgattatgat aaaagcaagg tcaaagtttt cgttaatatg 117961 tttggccgtg aaacgccggt tgagctggaa tttacccaaa tcgataaatt gtaatgtgaa 118021 aaaacttgaa attgctatat ataaatgata atatagcaaa ggtacgtctt ggacttatcc 118081 aaggcaacta gcatgatatt tcgtcattca tataaagaat gaaaccttga gtgggagggt 118141 ttaccctatt accacatcac ggacttaagg aggtgtgtct cgtggctaaa aaagtagtta 118201 aagttgtaaa attgcaaatt cctgctggaa aagctaaccc agcaccacca gttggacctg 118261 cacttggtca agccggtgtt aacatcatgg gattctgtaa ggagtttaac gctcgtacag 118321 ctgaccaagc tggtttaatc attcctgttg aaatttcggt ttacgaagac cgttcattta 118381 catttattac aaaaactcca cctgctgcag tattgcttaa aaaagcagct ggaattgagt 118441 ctggttctgg tgaaccaaac cgtaataaag tggcaaccgt taagcgcgat aaagtacgcg 118501 aaatcgctga aacgaaaatg cctgacttaa acgcagcaga cgttgaagcg gcaatgcgca 118561 tggttgaagg tactgcccgc agtatgggta ttgtaatcga ggattaattt gtttcttgtc 118621 gggttgcgag ttttaacaag ttcgcaaccc ttattcgtgg gaggttattc cgctataacc 118681 acataaggag gaaattttaa aatggctaaa aaaggtaaaa agtacgttga agctgctaag 118741 cttgtagacc gttctaaagc ttacgacgtc tctgaagcag tagctctcgt taaaaaaaca 118801 aacacagcta aattcgacgc tacagttgaa gtggctttcc gtttaggggt tgaccctcgt 118861 aaaaacgacc agcaaatccg tggagcagtt gtgcttccaa acggaactgg taaaactcag 118921 cgcgttctcg ttttcgcaaa aggcgaaaaa gcgaaagaag ctgaagctgc tggtgcagat 118981 ttcgtaggcg atactgacta catcaacaaa attcaacaag gctggttcga tttcgatgtt 119041 atcgtagcta cacctgacat gatgggtgaa gttggtaaaa tcggtcgtgt acttggacca 119101 aaaggtttaa tgccgaaccc taaaactggt acagttactt tcgaagttga aaaagctatc 119161 ggcgaaatca aagctggtaa agttgaatac cgcgttgata aagctggaaa cattcatgtt 119221 cctatcggta aagtttcttt cgaggatgaa aaacttgttg agaacttcac aacaatgtac 119281 gatacaatcc ttaaagctaa acctgctgca gctaaaggcg tttacgtgaa aaacgttgct 119341 gtaacttcta ctatgggacc tggtgtcaaa gtagactctt caacttttaa cgtaaaataa 119401 tattgacatg acatcaacat tctgatatta ttcaaaatgt tgtaaaatag aatatcattt 119461 ataccgtaga cagtaggggc ctaaccgctt aattatccta ccgaggtgta tattatcaca 119521 gctattacgt tacgtatgct tgtatataca gcctccatgt ctcatggagg ctttttatat 119581 ggaatccgtc gtctcagtcg tgatcaccta acggtataag tgttacacaa gaatctacag 119641 gaggtgtaac catgagcagc gcaattgaaa caaaaaaagt tgttgttgaa gaaattgctt 119701 ctaaactgaa agaaagtaaa tcaacgatca tcgttgacta tcgcggactt aacgtttctg 119761 aagtaactga acttcgtaaa cagcttcgcg aagctaacgt tgagttcaaa gtttacaaaa 119821 atacgatgac tcgccgtgcg gttgaacaag ctgagcttaa tggtttgaat gatttcttaa 119881 ctggaccgaa cgcgatcgca ttcagcactg aagatgttgt cgctccggct aaagttctta 119941 atgacttcgc taaaaatcac gaagctcttg aaatcaaagc tggcgttatc gaaggtaaag 120001 tttctactgt tgaagaagtg aaagctcttg ctgaacttcc atcacgcgaa ggcttgcttt 120061 ctatgttgct tagcgtactt caagctccag ttcgcaacct tgctcttgct gcaaaagctg 120121 tggcagaaca aaaggaagaa caaggcgctt aatctaatca gtttttcata aattaaaaca 120181 aaatggagga attacaaatg gctttaaata tcgaagaaat cattgcttcc gttaaagaag 120241 caactgtact tgaattgaac gacctagtaa aagcaatcga agaagaattt ggcgtaactg 120301 ctgctgctcc tgtagctgta gctggcggag ctgctgctgg cggagctgct gaagagcaaa 120361 gcgaattcga tcttatcctt gctggtgcag gatctcaaaa aatcaaagtt atcaaagttg 120421 tacgtgaaat cactggtctt ggcttgaaag aagctaaaga gcttgttgac aacactccaa 120481 aaccacttaa agaaggtatt gctaaagaag aagctgaaga gcttaaagct aaacttgaag 120541 aagttggcgc ttctgtagaa gttaagtaat cttcacttac ctgtagggga agctcgcttt 120601 tatgaggcga gctttttctt tgccattctt taagccatga aaaaaggagg ttctaataat 120661 gagtgagcac tattattcag aaaaaccttc agtaaaaagc aacaagcaaa cctggtcttt 120721 taggcttcgg aataaagatt tcacgtttac cagcgacagc ggggtttttt ctaaaaaaga 120781 agttgatttc ggctcccgcc tgctgattga ttcttttgaa gagcctgagg ttgagggcgg 120841 cattttagat gtaggctgcg gatacggccc gattggttta tcgctcgcca gcgactttaa 120901 agaccggacc atccacatga ttgacgttaa tgagagagcc gtagaactat caaatgaaaa 120961 tgcggaacag aacggaataa caaacgttaa gatttatcaa agcgatttgt tttcaaacgt 121021 tgattctgct caaacatttg cttctattct tacaaatccc ccaatccgag ccggaaaaaa 121081 agttgtccat gctatctttg agaaaagcgc tgaacactta aaagcttcag gtgaattgtg 121141 gatcgtcata cagaaaaagc aaggcgcgcc ttctgccatt gaaaagctcg aggaactgtt 121201 cgatgaagtt tccgtcgttc aaaaaaagaa aggctattat atcataaaag caaaaaaagt 121261 ttgactcggt attttaacta tgttaatatt gtaaaatgcc aatgtatata ttttgcttga 121321 tatgatgaat tgtcaatatc tatgtataaa ttatacaagt atggaaatgc taataaaatc 121381 ggtatttgtt tttggatgtg gttttcttaa ttagaaaccc ttttttcttt tgtcttgtaa 121441 aagtattttc tttctttgga agaaatgctt attacacata taatacgcat gatttgaggg 121501 gtgaatcagt tgacaggtca actagttcag tatggacgac accgccagcg cagaagctat 121561 gctcgcatta gcgaagtgtt agaattacca aatctcattg aaattcaaac ctcttcttat 121621 cagtggtttc ttgatgaggg tcttagagag atgtttcaag acatatcacc aattgaggat 121681 ttcactggta acctctctct tgagttcatt gattatagtt taggtgagcc taaatatcct 121741 gtagaggaat caaaagaacg tgatgtgact tactcagctc cgctaagagt gaaggttcgt 121801 ttaattaaca aagaaactgg agaggtaaaa gaccaagatg tcttcatggg tgatttccct 121861 attatgacag atacaggtac ttttatcatt aacggtgcgg aacgtgttat cgtttcccag 121921 cttgttcggt ctccaagtgt atatttcagt ggtaaagtag acaaaaacgg taaaaaaggt 121981 tttaccgcaa ctgtcattcc aaaccgtggc gcatggttag aatacgaaac tgatgcgaaa 122041 gatgttgttt atgtccgcat tgatcgcaca cgtaagttgc cggttacggt tcttttgcgt 122101 gctctcggct tcggctccga tcaagagatt cttgatctca taggagaaaa cgaatacctg 122161 cgaaatacgc ttgataaaga taacacagaa aacagcgaca aagcgttgct ggaaatttac 122221 gagcgtctcc gtcctggaga gccgcctaca gtagaaaatg cgaaaagctt gcttgattct 122281 cgtttctttg atccgaaacg atacgatctt gccaatgtag gacgctataa aattaataaa 122341 aaacttcata ttaagaatcg cctcttcaat cagagacttg ctgaaacgct tgttgatcct 122401 gaaacaggag aaatccttgc tgaaaaaggc cagattcttg atagaagaac gcttgataaa 122461 gtactgccat acttagaaaa cggaatcggt tttagaaagc tgtatccgaa tggcggcgtt 122521 gttgaagatg aagtgactct tcaatcaatt aaaatctttg ctccgactga tcaagaagga 122581 gaacaggtta tcaatgtaat cggcaatgct tacatcgaag aagagattaa aaacatcacg 122641 cctgctgata ttatttcttc aatcagctac ttcttcaacc tgctgcacgg agtaggcgac 122701 acagatgata tcgatcatct tggaaaccgc cgtttacgtt ctgtaggcga gcttctccag 122761 aaccaattcc gtatcggttt aagccgtatg gagcgtgtgg ttcgtgagag aatgtcaatt 122821 caagatacga atacaattac gcctcagcag ctgatcaata ttcgtcctgt tattgcgtcc 122881 attaaagagt tctttggaag ctcacagctt tctcaattca tggatcagac gaacccgctt 122941 gctgaattaa cgcacaagcg tcgtctgtca gcattaggac cgggcggatt gacacgtgag 123001 cgtgccggaa tggaagtgcg tgacgttcac tactcccact atggccgtat gtgtccgatt 123061 gaaacgcctg agggcccgaa catcggtttg atcaactcac tatcatctta tgcaaaagta 123121 aaccgttttg gctttattga aacgccatat cgccgcgttg accctgaaac agggaaggta 123181 acgggcagaa tcgattactt aactgctgat gaagaggata actatgttgt cgctcaagcg 123241 aatgctcgtc ttgatgacga aggcgccttt attgatgaca gcatcgtagc tcgtttccgc 123301 ggggagaaca ccgttgtttc cagaaatcgt gtagactaca tggatgtatc gcctaagcag 123361 gttgtatctg ctgcgacagc atgtatcccg ttcttagaaa acgatgactc caaccgtgcc 123421 ctcatgggag cgaacatgca gcgtcaggct gtgcctttga tgcagccgga agcgccattt 123481 gttggaactg gtatggaata cgtatcagga aaagactctg gtgccgctgt tatttgtaaa 123541 caccctggta tcgttgaacg cgtagaagcc aaaaacgttt gggttcgccg ttatgaagaa 123601 gtagacggtc aaaaagtaaa aggaaacctg gataaataca gcctgctgaa atttgtccgc 123661 tctaaccaag gtacgtgcta caaccagcgt ccgatcgtaa gtgtcggcga tgaagtggta 123721 aaaggagaaa tccttgctga cggtccttct atggagcttg gtgaacttgc acttggccgt 123781 aacgtaatgg tcggcttcat gacgtgggat ggctacaact atgaggatgc catcatcatg 123841 agtgaacgcc tagtgaagga tgatgtttat acatctatcc acattgaaga atacgaatca 123901 gaagcacgtg atacgaaact tggacctgaa gaaatcactc gcgatattcc aaacgtcggt 123961 gaagatgcgc ttcgcaatct tgatgaccgc ggaatcatcc gtattggggc agaagtaaaa 124021 gacggagatc ttcttgttgg taaagtaacg cctaaaggcg taactgaact gactgccgaa 124081 gaacgccttc ttcacgccat ctttggcgag aaagcccgcg aggttcgtga tacttctctt 124141 cgtgtgcctc atggcggcgg cggaattatc catgacgtta aagtcttcaa ccgtgaagac 124201 ggagacgaac ttcctccagg tgttaaccag ttagtacgcg tatatatcgt tcagaaacgt 124261 aagatttctg aaggggataa aatggccggt cgtcacggta acaaaggtgt tatctctaag 124321 attcttcctg aagaggatat gccttacctt cctgacggca caccaattga tatcatgctt 124381 aacccgctgg gcgtaccatc acgtatgaac atcgggcagg tattggaact tcacatgggt 124441 atggccgctc gttaccttgg cattcacatt gcatctcctg tatttgacgg agcgcgagaa 124501 gaggatgtct gggaaacact tgaagaagcc ggcatgtctc gtgacgccaa aacagtgctt 124561 tacgacggac gtactggaga gccgtttgat aaccgtgtat ctgtcggtat catgtacatg 124621 atcaaactgg ctcacatggt tgacgataaa cttcatgcac gctctacagg cccttactca 124681 cttgttacgc agcagcctct tggcggtaaa gcgcaatttg gcggacagcg ttttggtgag 124741 atggaggttt gggcacttga agcttacggt gcggcttaca ctcttcaaga aattctgact 124801 gttaagtctg atgacgtggt tggacgtgtg aaaacatacg aagccatcgt taaaggcgac 124861 aatgttcctg aaccaggtgt tccggaatca ttcaaagtat taatcaaaga acttcaaagc 124921 ttaggtatgg atgtcaaaat cctttctggt gatgaagaag aaatagaaat gagagattta 124981 gaagacgaag aagatgcgaa acaagctgac ggcctggcat tatcaggtga tgaagagccg 125041 gaagaaacag catctgcaga cgttgaacgc gatgtagtaa caaaagaata atctctagtt 125101 ataaaggcaa gtgacatcgg ttaatccgaa gataaaaagg gaggtaggcc ccttgctaga 125161 tgtgaacaat tttgagtata tgaacatcgg tcttgcttca ccagataaaa tccgttcatg 125221 gtcttttggt gaagtgaaaa agcctgaaac gataaactat cgtacgttaa aacctgaaaa 125281 ggacggtcta ttctgcgaac gcattttcgg accgactaag gactgggaat gtcattgcgg 125341 gaagtacaag cgagttcgtt ataaaggcgt agtttgtgac cgctgcggag tcgaagtaac 125401 acgggctaaa gtccgtcgtg agagaatggg gcacattgaa ctggctgccc cagtttccca 125461 catttggtat ttcaaaggta ttccaagccg tatgggtctt gtgctggata tgtcacctcg 125521 tgctttagaa gaagtcattt actttgcttc ttacgttgta actgatccgg cgaatacacc 125581 gcttgaaaag aaacagcttc tgtctgagaa agaataccgt gcttatcttg ataaatacgg 125641 taataaattc caagcatcta tgggtgctga agcaattcat aaacttcttc aagatatcga 125701 tcttgtaaaa gaagttgata tgttaaaaga agagctgaaa acttcacaag gacaacgccg 125761 tactcgtgcg atcaaacgtc ttgaagtttt agaagccttc cgtaactcag gaaacaagcc 125821 ttcttggatg atccttgatg tgcttcctgt tattcctccg gagcttagac cgatggttca 125881 gctagatggc ggacgttttg cgacttctga tttgaatgac ctttatcgtc gtgtcatcaa 125941 ccgtaacaat cgtttgaaac gccttttgga ccttggtgcg cctagcatca tcgttcaaaa 126001 cgaaaagcgt atgcttcaag aggctgtcga tgccctaatt gacaacggcc gccgcggacg 126061 ccctgtaaca ggtcctggaa acagaccgtt aaaatctctt tctcacatgc tgaaagggaa 126121 gcaaggccgt ttccgtcaaa accttcttgg taaacgtgtc gattactccg gacgttctgt 126181 aatcgttgtt ggtcctcatt tgaaaatgta ccaatgcgga ttaccgaagg aaatggcact 126241 tgaacttttc aaacctttcg ttatgaaaga acttgttgaa aaaggtcttg ctcacaacat 126301 taagagtgcg aaacgcaaaa ttgagcgcgt acagcctgaa gtttgggatg tactagaatc 126361 agttattaag gagcatccgg tactgctgaa ccgtgcccct acacttcaca gattaggtat 126421 ccaggcgttt gaaccaacgc ttgttgaagg acgcgcaatc cgtcttcacc cgctcgtatg 126481 tacagcttac aacgctgact ttgacggtga ccaaatggcg gttcacgtac cattatctgc 126541 tgaagcacaa gctgaagcac gcatcttgat gcttgctgct caaaacatct tgaaccctaa 126601 agatggtaaa ccggttgtaa caccgtctca ggatatggta ctaggtaact attacctgac 126661 acttgagcgt gccggtgctg tcggtgaagg tatggtcttc aagaatacag acgaagcgct 126721 tcttgcttat caaaacggat atgttcacct tcatacgaga gtagctgttg cagctaactc 126781 acttaagaat gtgacattta ccgaagaaca gcgctcaaaa ttgttaatta caactgtcgg 126841 taagcttgtc ttcaatgaaa ttcttccgga atcattccct tacatgaatg aaccaacgaa 126901 gagcaacatt gaagagaaaa cacctgaccg tttcttctta gaaaaaggtg ctgatgttaa 126961 agctgttatc gcacagcagc caatcaatgc gccgtttaaa aaaggcattc tgggtaaaat 127021 catcgcggaa atctttaaac gattccatat tacggaaacg tctaaaatgc ttgaccgcat 127081 gaaaaaccta ggtttcaaat attcaactaa agctggtatt acagttgggg tttctgacat 127141 cgtcgtactc gatgataaac aagaaattct tgaggaagcg caaagcaaag ttgacaacgt 127201 tatgaagcaa ttccgccgcg gtcttatcac tgaagaagaa cgctatgaga gagtcatctc 127261 tatctggagt gctgcaaaag acgttatcca aggcaaactg atgaaatcac ttgatgaact 127321 caacccgatc tacatgatga gtgactctgg tgcccgtggt aacgcatcta actttacgca 127381 gcttgccgga atgcgcggcc tgatggccaa cccggctgga cgtatcattg agttgccgat 127441 caaatcaagt ttccgtgaag gtctgacagt attggagtac tttatctcca cacacggtgc 127501 gcgtaaaggt cttgccgata ccgctcttaa aactgctgac tcaggttacc ttacacgccg 127561 tctcgttgac gttgctcagg atgttatcat ccgtgaaact gattgcggaa ctgaccgagg 127621 cattcttgct aagcctctta aagaaggaac tgaaacaatt gagcgcttag aagaacgctt 127681 aatcggacgt tttgcaagaa aacaagtgaa gcaccctgaa acaggtgaag tgcttgtgaa 127741 tgaaaacgaa ctgatcgatg aagataaagc actggagatt gtcgaagccg gcattgaaga 127801 agtgtggatc cgttctgcct tcacatgtaa tacgcctcat ggtgtatgta aacgatgcta 127861 tggccgaaat cttgcaactg gctccgatgt tgaagtcggt gaagctgtcg gaatcattgc 127921 tgcccaatca atcggtgagc ctggtacaca gttaacaatg cgtacattcc atacaggcgg 127981 ggttgccgga gacgatatca cacagggtct tccgcgtatc caagagcttt tcgaagcgcg 128041 taatccgaaa ggtcaggcaa caattacaga aatcgacggt acagtcgttg agatcaatga 128101 agttcgtgat aagcaacagg aaattgtggt tcaaggcgca gtggaaacac gttcttatac 128161 ggcaccttac aactcccgcc tgaaagtagc ggaaggagat aaaattactc gaggccaagt 128221 actgacagaa ggttcaatcg atccgaaaga acttcttaaa gtgactgacc tgacgactgt 128281 tcaagagtat cttctccatg aggttcaaaa ggtttaccgt atgcagggtg ttgaaatcgg 128341 tgataaacac gtagaagtaa tggttcgcca gatgcttcgc aaagtacgcg tgattgatgc 128401 cggtgacact gatgtgcttc caggtacatt gcttgatatt caccaattta ctgaagcgaa 128461 caaaaaggta ttgcttgaag gcaaccgacc agctacaggc cgtcctgtct tactcggtat 128521 tacaaaagca tctcttgaaa ctgattcatt cttatctgct gcttccttcc aggaaacaac 128581 acgtgtcctt acagatgcag cgatcaaagg taagcgtgac gagcttctcg gcttgaaaga 128641 gaatgttatc atcggtaagc ttgttccagc aggtacagga atgatgaaat accgtaaagt 128701 aaaaccagta tcaaatgttc agccgactga cgatatggtc ccggttgaat aactgattta 128761 actctgctga aagactgcaa aaacagtctt tcagcagata tatttatgaa aaagtcactc 128821 tatgagaaga acgaatctaa aaaatgtcat accttgttga cattcgtctc ctagaatgat 128881 aatataacca aggtgctcga aataaacctg ttactttgga ggatatgttt atgtcttatg 128941 ataaagtatc acaggccaaa tcaattatta ttggtacgaa gcaaacagtg aaagctctaa 129001 agcgaggttc agtaaaggaa gtagtcgttg caaaagacgc agatccgata ctcacgtcaa 129061 gtgttgtttc acttgctgaa gatcaaggta tctctgtctc aatggttgaa tccatgaaaa 129121 agctcggcaa agcctgcgga attgaggtag gagcagccgc tgttgccatt attttataac 129181 gtacttttgt ttttgcgtaa gattccatct tgtgtaaaga cattgttttt tgccttttga 129241 tgaaccacct gggtatgtgg gttataaaac gtaatgaagg gaggaaaaat tcatgcctac 129301 aattaatcag ctaattcgca aaggacgcgt gagtaaagta gaaaactcaa agtctcctgc 129361 acttaacaaa ggatacaaca gctttaaaaa agagcacact aacgtatctt ctccacaaaa 129421 acgcggggta tgtactcgtg ttggtacaat gacaccgaaa aaaccgaact cagcacttcg 129481 taaatatgct cgtgttcgtt tgactaacgg aatcgaggtt actgcttaca ttcctggtat 129541 cggtcacaac ctgcaagagc acagtgttgt acttatccgc ggcggacgtg taaaagactt 129601 accaggggta cgttaccaca tcgttcgtgg tgcgcttgat actgctggag ttgaaaaccg 129661 tgcacaaggc cgttctaaat acggtacgaa aaaacctaaa gcaaaataat atacgaaaat 129721 acgcataatt gatgaaggga ggatattcag atgccacgta aaggtcctgt agcaaaaaga 129781 gatgttttac ctgatccgat ttacaactct aagcttgtat ctcgtttaat caacaaaatg 129841 atgatcgatg gtaaaaaagg taagtctcaa acgatcctat acaagtcatt cgatatcatt 129901 aaagaacgta ctggcaatga tgcaatggag gttttcgaac aagcattgaa aaacatcatg 129961 cctgtacttg aagtaaaagc acgccgtgta ggtggtgcga actaccaagt tcctgtagaa 130021 gttcgtcctg aacgtcgtac gactcttgga cttcgctggt tagttaacta cgctcgtctt 130081 cgtggagaaa aaacgatgga agagcgttta gctaacgaaa tccttgacgc agctaacaac 130141 actggtgctg ctgttaagaa acgtgaagac actcataaga tggctgaagc aaacaaagca 130201 tttgctcact atcgctggta ggatttatag attaacaaaa cacaatttcc taataaggaa 130261 ggagaaatta cccaatggca agagagttct ccttagaaaa aactcgtaat atcggtatca 130321 tggctcacat cgatgccggt aaaacgacta ctacagaacg tatcttgttc tatactggtc 130381 gtatccacaa aattggtgaa actcatgaag gagcttcaca aatggactgg atggagcagg 130441 aacaagaacg tggtatcaca atcacttccg ctgcgactac tgcacagtgg aaaggatacc 130501 gcgtaaacat catcgatact ccaggacacg tagacttcac agttgaagtt gaacgttctc 130561 ttcgtgtact tgatggtgct gttgctgtac ttgacgcgca atcaggcgtt gagcctcaaa 130621 cagaaactgt ttggcgtcag gcaacaactt atggagtacc gcgtatcgtt tttgttaaca 130681 aaatggacaa aatcggtgca gacttccttt actctgtagg aactttaaga gaccgtcttc 130741 aagcaaacgc tcatgcaatt caattgccga tcggtgctga agataacttc gaaggtatca 130801 ttgaccttgt agaaaacgtt gcgtatttct acgaagatga cctcggaact cgttctgatg 130861 caaaagaaat ccctgaagag tacaaagagc aagctgaaga gcttcgcaac agccttattg 130921 aagctgtatg tgagcttgat gaagagctta tggataagta ccttgagggt gaagaaatca 130981 caattgacga gttaaaagca ggaattcgta aaggtacatt aaatgttgaa ttctaccctg 131041 ttcttgttgg ttctgccttc aaaaacaaag gtgttcaact agtacttgat gctgttcttg 131101 actaccttcc tgcaccaact gacgttgctg caatcaaagg tacacgtcct gatacaaatg 131161 aagagattga gcgtcattct tctgacgaag agccattctc tgcattagca tttaaagtta 131221 tgactgaccc ttacgttggt aagttgacgt tcttccgtgt gtactctgga acacttgatt 131281 ctggttcata cgtgaaaaac tctactaaag gcaaacgtga gcgtgttgga cgtattcttc 131341 aaatgcacgc taacagccgt gaagaaatct ctactgtata cgcaggggat atcgcagctg 131401 ctgtaggtct aaaagataca actactggag atactctatg tgatgagaag gatcttgtta 131461 tccttgagtc aatggaattc ccagaaccag ttatcgacgt tgctattgag cctaaatcaa 131521 aagctgacca agataaaatg ggtatcgctt tagcgaaact tgctgaagaa gatcctacat 131581 tccgtactca aacaaaccca gaaactggcc aaacgatcat ctctggtatg ggtgaacttc 131641 accttgatat cattgttgac cgtatgaaac gcgaatttaa agtagaagcc aatgttggtg 131701 ctcctcaagt tgcgtaccgt gaaacattcc gtaccggtgc aaaagttgaa ggtaaattcg 131761 tacgtcagtc tggtggacgc ggtcagttcg gacacgtttg gatcgaattc gaaccaaacg 131821 aagaaggcgc tggctttgaa tttgaaaatg cgattgtcgg tggggtcgtt cctcgtgaat 131881 acatcccagc tgttcaagca ggtctggaag atgcactcga aaatggtgta ctagcaggct 131941 tcccgcttat cgacattaaa gctaaacttt tcgacggttc ttaccatgat gttgactcaa 132001 acgaaatggc atttaaagtc gctgcttcta tggcattgaa aaatgcagtc agcaaatgta 132061 acccagttct tcttgaacca atcatgaaag tggaagtggt tattccagaa gaatatatgg 132121 gagatatcat gggtgatatc acttcacgtc gcggacgcgt agaaggtatg gaagcacgcg 132181 gtaacgctca agttgttcgt gctatggttc ctcttgctga aatgttcggt tacgctactg 132241 cacttcgttc taatacgcaa ggtcgcggta cgttcactat gcacatggat cactacgaag 132301 aagtgccgaa gagcgtcgca gaagaaatta tcaaaaaaaa taaaggcgaa taattgattt 132361 tgccgcttaa ctcaagtata actactattg taagatgagg aagtgaaagc tttctttcac 132421 ttcctatcac tctatacatt actaattaaa agctcttaag gaggatttta gaatggctaa 132481 agaaaaattc gaccgttcca aatcacatgc caatattggt acaattggac acgttgacca 132541 tggtaaaaca actttaactg ctgctatcac aacagtactt cataagaaat ctggtaaagg 132601 tacagctatg gcgtacgatc aaattgatgg tgctccagaa gaacgcgagc gcggtatcac 132661 aatctctact gcacacgttg agtacgaaac tgaaactcgt cactatgcac acgttgactg 132721 cccaggacac gctgactatg ttaaaaacat gatcactggt gctgcgcaaa tggacggagc 132781 tatccttgta gtatctgctg ctgatggccc aatgccacaa actcgtgagc acatccttct 132841 ttctaaaaac gttggtgtac catacatcgt tgtattctta aacaaatgcg acatggtaga 132901 cgacgaagag cttcttgaac tagttgaaat ggaagttcgc gatcttctta gcgaatacga 132961 cttccctggt gatgatgtac cagttgttaa aggttctgct cttaaagctc ttgaaggaga 133021 cgctgagtgg gaagctaaaa tcttcgaact tatggatgcg gttgatgagt acatcccaac 133081 tccagaacgc gacactgaaa aaccattcat gatgccagtt gaggacgtat tctcaatcac 133141 tggtcgtggt acagttgcta ctggccgtgt agaacgcgga caagttaaag tcggtgacga 133201 agttgaaatc atcggtcttc aagaagagaa caagaaaaca actgttacag gtgttgaaat 133261 gttccgtaag cttcttgatt acgctgaagc tggtgacaac attggtgccc ttcttcgcgg 133321 tgtatctcgt gaagaaatcc aacgtggtca agtacttgct aaaccaggta caatcactcc 133381 acacagcaaa ttcaaagctg aagtttacgt tctttctaaa gaagagggtg gacgtcatac 133441 tccattcttc tctaactacc gtcctcagtt ctacttccgt acaactgacg taactggtat 133501 catccatctt ccagaaggcg tagaaatggt tatgcctgga gataacactg aaatgaacgt 133561 tgaacttatt tctacaatcg ctatcgaaga aggaactcgt ttctctattc gtgaaggcgg 133621 acgtactgtt ggttcaggcg ttgtttctac aatcactgag taatagtatg gttttaaacg 133681 agacccctgt gggtctcgtt ttttgtttgc ttatcttttt cttgtataat aggatctatc 133741 atattcgagg ggttaatatt tatgattcct gaaaagaaat caatcgcaat catgaaagaa 133801 ctaagcattg gaaatacaaa gcaaatgctg atgattaatg gagttgacgt gaaaaatcca 133861 ttgctgcttt ttttacatgg cgggccggga acgccgcaaa tcggatatgt tagacattat 133921 caaaaagagc tggaacagta ttttacagta gttcattggg atcagagagg atcggggctt 133981 tcttattcta agcgaatttc gcatcactct atgacaataa atcacttcat taaagataca 134041 atccaagtca ctcaatggct tttagctcat ttttcaaaat caaaacttta cctagccggt 134101 cattcttggg gatcaatact ggcgcttcat gtgctgcagc agcgtcctga tttattttac 134161 acgtattatg gaatcagcca ggttgttaac ccgcaagatg aagaatcaac tgcttatcaa 134221 catattcgtg aaatttccga atcaaaaaaa gccagcatat tatctttcct tacacgtttc 134281 attggtgctc cgccttggaa gcaggatatc cagcacctta tctatcggtt ttgtgttgag 134341 ctaaccaggg gaggattcac tcaccgtcat cgtcaatctc tcgctgtatt atttcaaatg 134401 cttactggca atgagtatgg agtgcggaac atgcacagct tccttaatgg attgcgcttc 134461 agtaaaaaac atttaactga tgagttgtac cggtttaatg cttttacatc agttccttct 134521 attaaagtac cgtgtgtttt catttcaggg aaacatgact taattgttcc tgcagaaata 134581 tcgaaacagt attatcaaga acttgaggca cctgaaaagc gctggtttca atttgagaat 134641 tcagctcaca ccccgcatat tgaggagcca tcattattcg cgaacacatt aagtcggcat 134701 gcacgacacc atttatgata gatccttgat aaataagaaa aacccctgta taataaaaaa 134761 agtgtgcaaa tcatgcatat tttaaataag tcttgcaaca tgcgcctatt ttctgtataa 134821 tggtgtatgt tggtctttga ctgcgatgaa gtgagaggtt gctgacacac ccggccgctt 134881 tgccatggca aggtgttcag gtttttctca cggagaactg tctaacgtga tgtaggcgaa 134941 aaggagggaa aataatggca aaacaaaaaa ttcgtattcg tttgaaagca tatgatcata 135001 gaatccttga tcaatctgca gagaagattg ttgaaacggc aaaacgttct ggtgccagcg 135061 tatctggtcc gattccgttg ccaactgaaa aatcagttta cacaatcctt cgtgcggtgc 135121 acaaatacaa agattctcgt gagcaatttg aaatgcgtac acataaacgt ttaatcgaca 135181 ttgtgaaccc aacaccacaa actgttgatg ctcttatgcg attagactta ccatctggtg 135241 tcgatatcga aattaaactt taattctaaa atatagaatg atcttaatag gaggtgtgac 135301 gaatgaccaa aggaatctta ggaagaaaaa ttggtatgac gcaagtattc gctgagaatg 135361 gtgatcttat tccggtaact gttatcgagg ctgctccaaa cgttgttctt caaaagaaaa 135421 cagctgaaaa cgacggttac gaagcaatcc agcttggttt tgacgacaag cgtgaaaagc 135481 tttctaacaa acctgaaaaa gggcacgttg caaaagcgga aactgctcct aagcgcttcg 135541 ttaaagaatt acgcggagtg gaaatggatg cgtatgaagt tggtcaggaa gtcaaggttg 135601 aaattttctc tgctggagaa atcgtagatg taacaggagt atctaaaggt aaaggtttcc 135661 aaggtgcgat caagcgccac ggacaatctc gcggacctat gtctcacggt tcacgctacc 135721 accgtcgtcc tggttcaatg ggacctgtag atcctaaccg tgtattcaaa ggtaaattat 135781 tacctggacg tatgggcgga gagcaaatca ctgttcaaaa ccttgaaatc gtaaaagttg 135841 atgcagaacg caatcttctt ttgatcaaag gtaacgtacc tggtgcgaag aaatctttaa 135901 tcactgttaa aagtgctgtt aaatctaaat aattctctta ggaaaggagg aaattgatta 135961 tgccaaaagt agcattatac aaccaaaacg gttctactgc tggtgacatc gaattaaacg 136021 cttctgtatt tggtatcgaa ccaaatgaga gtgttgtatt cgacgctatt cttatgcaaa 136081 gagcttcctt acgtcaagga actcacaaag taaaaaatcg ttctgaagta cgcggcggag 136141 gtcgtaaacc atggcgtcaa aaaggtactg gacgtgcccg tcaaggttca atccgttcac 136201 cgcaatggcg cggaggtggt gtcgtattcg gcccaacacc acgcagctat tcttataaat 136261 tacctaaaaa agttcgccgc ttggcaatca aatcagtatt gtcttctaaa gtgatcgaca 136321 acaacatcat cgttcttgaa gatcttactc ttgatacggc taaaacaaaa gaaatggcag 136381 ctatccttaa aggattatct gttgagaaaa aagctttaat cgtaactgcg gatgcaaacg 136441 aagcagtagc attatctgct cgtaacattc ctggagttac tgttgttgaa gctaacggaa 136501 tcaacgtttt agacgttgtc aaccacgaga agcttctgat tacaaaagca gcggttgaaa 136561 aagtagagga ggtgcttgca taatgaaaga tcctcgtgat gttctaaagc gccccgtcat 136621 tactgaacgt tctgccgatt taatgactga aaaaaaatat acttttgaag ttgatgtaag 136681 agctaacaaa acagaagtga aagacgcggt tgaaagcatc tttggagtga aagttgacaa 136741 agtcaacatc atgaactaca aaggcaaatc aaaacgtgtt ggacgctaca ctggtatgac 136801 tagccgtcgc agaaaagcga tcgtaaaact tactgcagac agcaaagaaa tcgaaatttt 136861 tgaagcttaa ttatctgtaa aaagaaggag ggaaattcaa aatggcgatt aaaaagtata 136921 aaccgacctc taatggacgt cgtggcatga caacttcaga ttttgctgaa atcacgactg 136981 acaagccgga aaaatccttg cttgctcccc ttcacaaaaa aggcggacgt aacaaccaag 137041 gtaaattgac tgtacgtcac caaggtggcg gacataaacg ccaataccgt gttatcgact 137101 tcaaacgcga taaagatggt atacctggac gcgttgctac agttgaatac gatccaaacc 137161 gttcagctaa catcgctcta atcaactatg cagacggaga aaaacgttac attcttgctc 137221 ctaaaggaat tcaagtaggt actgaaatca tgtcaggtcc tgaagctgac attaaagtag 137281 gtaatgcact tccacttatc aacatccctg ttggtacagt tgtgcataac attgaattaa 137341 aacctggtaa aggcggacag cttgtacgtt cagctggtac atctgctcag gttcttggta 137401 aagaaggtaa atacgttctt gtacgtctta actctggtga agttcgcatg atcctttctg 137461 cttgccgtgc ttctatcggt caagtaggta acgaacagca cgaacttatc aacattggta 137521 aagctggacg ttctcgctgg aaaggcatcc gtcctacagt tcgtggttct gtaatgaacc 137581 ctaacgatca cccacacggt ggtggtgaag gacgtgcgcc aatcggacgt aaatcaccaa 137641 tgtctccatg gggcaaacca actcttggat tcaagactcg taagaaaaag aacaaatccg 137701 ataaatttat cgtacgtcgt cgtaaaaata aataacgggg ttgtctacgg ttcttttcgg 137761 accgtagtgc aatcacgaag ggaggttcca aaatggctcg cagcttaaaa aaaggaccat 137821 ttgtcgatgg acacttgatg actaaaatcg agaaattaaa tgaaacagac aagaaacaag 137881 tcgtaaaaac ttggtctcgt cgttctacta ttttcccaca gtttattggt cacacaatcg 137941 cagtctatga cggacgtaaa cacgtgcctg tattcatctc tgaagatatg gtagggcaca 138001 agttgggtga attcgctcca actcgtacgt acaaaggtca tgctagtgat gacaaaaaaa 138061 caagacgcta agagaggagg cttttaaatg caagctaaag ctgttgcaag aacagtccgt 138121 attgctcctc gtaaagcacg tctagtaatg gacctgattc gaggcaagca agtaggtgag 138181 gcagtatcaa tcttgaacct tacaccaaga gctgcttctc caattatcga gaaagtatta 138241 aaatccgcta ttgcaaatgc tgagcataac tatgaaatgg acgctaacaa cctggttatt 138301 tctcaagcat tcgttgacga aggccctacg ttaaaaagat tccgcccacg tgctatggga 138361 cgtgcgagcc aaatcaacaa acgtacgagc cacattacaa tcgttgtatc agaaaagaag 138421 gagggataag tagtgggtca aaaggtaaat ccagtcggtc ttcgtatcgg agtcattcgt 138481 gattgggaat ctaagtggta cgctggtaaa gattacgctg acttcctgca cgaagattta 138541 aaaattcgtg aatacattag caaacgcctt tctgacgctt ctgtttctaa agtagaaatt 138601 gagcgtgcag caaaccgcgt taacattacg atccacacag ctaagcctgg tatggttatc 138661 ggtaaaggcg gttctgaagt cgaagcactt cgcaaagccc ttaacagcct tactggcaag 138721 cgtgtacaca ttaacattct tgaaatcaaa agagcagatc ttgatgcaca gctagttgct 138781 gacaacatcg ctcgtcaatt agaaaaccgt gtttctttcc gccgtgcgca gaaacaacaa 138841 atccaacgta ctatgcgtgc tggagcacaa ggtgtgaaaa caatggtttc tggtcgtctt 138901 ggcggtgcag atatcgctcg ttctgaatac tacagtgaag gaactgttcc attgcacaca 138961 ttacgtgcgg acattgacta tgcaacatct gaagctgata ctacttacgg taagcttggt 139021 gtaaaagtct ggatctatcg tggagaggtt cttcctacta agaagaaaaa tgaggaagga 139081 ggaaaataat atgttattac caaaacgcgt taaatatcgc agagagcatc gcggaaaaat 139141 gcgtggccgt gcgaaaggcg gtactgaagt acatttcgga gaattcggta tccaagctct 139201 agaagcttct tggattacta accgtcaaat cgaagctgca cgtattgcga tgactcgtta 139261 catgaaacgt ggcggtaaag tttggatcaa aattttccct tctaaacctt acactgctaa 139321 accacttgag gtacgtatgg gatccggtaa aggggctcca gaaggttggg tagctgttgt 139381 aaaaccgggc aaagttttat ttgaaatttc tggtgtgtct gaagaggttg ctcgtgaagc 139441 gcttcgcctt gcatctcaca aattgccaat taaaacgaag ttcgtaaaac gtgaagaaat 139501 tggtggtgaa tcaaatgaaa gctaatgaaa ttcgtgacct taccactgct gaaattgaac 139561 aaaaagtaaa gtctcttaaa gaagaacttt tcaatcttcg ctttcaatta gcgacaggac 139621 aacttgaaaa tactgctcgc attcgtgaag tgcgcaaagc tatcgcgcgc atgaaaactg 139681 tgattcgtga aagagaaatt gctgctaata aataatcact gaggggaggt cgtgagcatg 139741 agcgaacgta accaacgcaa agtttaccaa ggccgtgttg tttctgacaa aatggataaa 139801 accattactg ttgttgttga gacatacaaa aaacatacac tttacggtaa acgcgtaaaa 139861 tactcaaaaa aattcaaagc acatgatgaa aataatcaag ctaaaatcgg tgacatcgtt 139921 aagatcatgg aaactcgtcc attgtctgca actaagcgtt tccgtctagt tgaagttgtc 139981 gaagaagctg ttattatcta ataaagttcg gaattctttt tccgaaggga ggtaacaaat 140041 aatgattcaa caagagactc gtttaaaagt agctgacaac tctggcgcac gtgaagtact 140101 tactattaaa gttcttggtg gttctggacg taaaacagct aacattggtg atgtaattgt 140161 ttgcacggtt aaacaagcaa caccaggagg cgttgtcaaa aaaggtgaag tcgtaaaagc 140221 tgttatcgtt cgcactaaaa gcggagcgcg cagaagtgac ggttcataca tcagcttcga 140281 tgagaatgca tgtgttatca tccgtgacga caagagccca cgcggaactc gtatcttcgg 140341 accagttgct cgtgaattgc gtgaaaacaa ctttatgaaa attgtttctc tagctccaga 140401 agttatctaa ttgaaataaa tgccttactc aaggaggtgc gatcaggatg catgtaaaaa 140461 aaggcgataa agttatggtt atctctggta aagataaagg caaacaagga acaatccttg 140521 ctgctttccc taaaaaggac cgcgttttag ttgaaggtgt taacatggta aagaaacact 140581 ctaaaccaac tcaagctaac cctcaaggcg gtatttctaa tcaagaggcg ccaattcatg 140641 tatcaaacgt tatgccgctc gatcctaaaa caggtgaagt gactcgcgta ggatacaaag 140701 tggaagatgg caaaaaagtt cgtgtagcaa aaaaatctgg gcaagttcta gataaatagt 140761 attaaaagga agggaggtct atctcatgaa ccgccttaaa gaaaagtaca ataaagaaat 140821 tgcacctgct ttaatgacta agttcaacta tgattcagtc atgcaagtgc ctaaaatcga 140881 aaaaatcgta atcaacatgg gtgttggtga cgctgttcaa aacgccaaag caatcgacag 140941 tgctgttgag gaattaacgt ttatcgcagg tcaaaaacct gtcgttactc gtgcgaagaa 141001 atcaattgct ggattccgtc ttcgtgaggg aatgcctatc ggtgcgaaag taactcttcg 141061 cggagagcgc atgtatgatt tccttgataa acttatttct gtatctttac cgcgtgtacg 141121 tgacttccgc ggggtttcta aaaaatcttt cgacggtcgc ggtaactaca cacttggtat 141181 caaagaacag ttaatcttcc ctgaaattga ctacgataaa gtaacaaagg ttcgcggaat 141241 ggacatcgtt atcgtaacaa ctgctaatac tgacgaagaa gctcgtgagc tattaactca 141301 agtaggtatg ccgttccaga aataatcaat gaaagggagg cgaaatcgtg gctaaaaagt 141361 ctatgattgc gaaacaacaa cgtacaccaa agtttaaagt acaagagtac acacgctgtg 141421 aacgctgcgg acgtccgcat tcagtcattc gtaaatttaa actttgccgt atttgtttcc 141481 gtgagcttgc atataaagga caaattcctg gcgtgaaaaa agccagctgg taatccccaa 141541 gaaagggaag gaggtaatta tataatggtt atgacagatc caattgcaga tatgctaact 141601 cgtattcgca atgcaaacat ggtacgtcat gagaagcttg aaattcctgc ttctaaattg 141661 aaaagagaaa ttgctgaaat tttaaagcgt gaaggtttca ttcgtgacgt tgagttcgta 141721 gaagacagca aacaaggtat tatccgcgtt ttcttgaaat acggacaaaa caacgagcgc 141781 gttatcactg gtcttaaaag aatcagcaag cctggtttgc gtgtttatgc taaatctaat 141841 gaagtacccc gcgtacttaa cggtcttgga atcgcgatta tttctacatc acaaggtgtt 141901 ttaacggaca aagaagcccg tgcaaaacaa gctggtggag aagttctagc atacgtttgg 141961 taagaagttt aacatgaatg gaggtgtttg gtatgtctcg tgtaggtaag aagctacttg 142021 agattccttc tgatgttaca gtaacgttaa atgataacaa cactgtagct gtgaaaggac 142081 caaaaggaga attaactcgt acgtttcacc ctgatatgga gattaaagta gaggacaatg 142141 tgcttacagt cgctcgtcct tctgatcaaa aagagcaccg tgccctgcat ggtacgactc 142201 gcagtctgct tggcaacatg gttgaaggtg tatctaaagg atttgaaaga ggtttggaat 142261 tagtcggtgt cggttaccgt gcttctaaat ccggaaataa acttgtttta aacgttggat 142321 actctcatcc tgttgagatc gttcctgaag aaggcatcga aatcgaagtt ccttctcaaa 142381 caaaagtagt tgtaaaaggt acagacaaag aacgcgtagg agctattgct gctaacatcc 142441 gcgctgtacg ttctccagag ccttacaaag gtaaaggaat ccgctacgaa ggtgaagttg 142501 ttcgccgtaa agaaggtaaa tctgctaagt aagatcgctt aaagtgaaga aaggagtgac 142561 ctagatgatt acgaaaacta gcaaaaatgc tgctcgtctt aaaagacacg ctcgtgttcg 142621 cgctaaactt tccggtactg ctgaaagacc gcgcctgaac gttttccgtt ctaacaagca 142681 catttacgct caaatcatcg atgatgtaaa tggtgtaaca cttgctagtg catctactct 142741 cgataaagac ttgaacgttg aaagcactgg agatacttct gctgctacta aagttggaga 142801 attagttgca aaacgcgctg ctgaaaaagg catttctgac gtagtatttg accgtggcgg 142861 atacttatac catggacgtg taaaagcttt ggctgatgcc gctcgtgaag ctggacttaa 142921 attttaataa aagaaggagg gacacatgat tatgcgtcgt attgacccaa gcaaattaga 142981 gttagaagaa cgcttagtta cggttaaccg cgtagcgaaa gttgttaaag gtggtcgtcg 143041 tttccgcttc gcagctctag tcgttgtcgg tgacaaaaac ggacacgtag gattcggtac 143101 tggtaaagca caagaagtac cagaagcgat tcgcaaagct gttgaagatg cgaaaaagaa 143161 tttgattgaa gtaccaatgg ttggaactac aattccacac gaaatcatcg gacgtttcgg 143221 tgcaggtaac atcttgttaa aacctgcttc tgaaggtact ggagttatcg ctggaggccc 143281 tgtacgtgcg gtacttgagc tagctggtgt agctgatatc ctttctaagt ctttaggttc 143341 taacacaccg atcaacatga ttcgtgcaac acttcaaggt ttaagtgaac ttaaacgtgc 143401 tgaagacgtt gcgaagcttc gtggaaaatc tgtagaagaa ctgttaggat aaggagggaa 143461 cattaatggc taaattagaa attaccctca aacgaagtgt aatcggtcgc ccggaagacc 143521 aacgcgttac tgtaagaaca cttggtttaa agaaaacaaa ccaaactgtt gttcatgaag 143581 acaacgctgc gatccgtggt atgattaata aagtatctca tttagtttct gttaaagaac 143641 aataaaaata tttgatcgga taaggaggtg tcctaatgaa acttcatgaa ttaaaacctt 143701 cagaaggttc acgcaaaacg cgtaatcgcg taggtcgtgg tattggttct ggcaacggta 143761 aaacagctgg taaaggtcac aaaggtcaaa acgctcgttc tggcggcggt gtacgccctg 143821 gattcgaggg gggacaaatg cctttattcc aacgtcttcc taaacgtggt ttcactaaca 143881 tcaaccgcaa ggaatacgct gtagtcaacc tagacaaatt gaacggtttt gcagaaggaa 143941 cggaagtcac tcctgaactt cttctagaga ctggtgttat tagcaaactt aatgcaggag 144001 taaagattct tggcaacggt aaattagaga aaaaattaac tgtaaaagcc aataaattct 144061 ctgcttctgc gaaagaagct gttgaagctg ctggcggtac agctgaggtg atctaacttg 144121 tttaaaacaa tctccaactt tatgcgtgtg agtgatatca ggaataaaat catattcact 144181 ttactcatgc ttatcgtctt tcgcataggt gcgtttattc ctgtgcctta cgttaacgct 144241 gaagcgttac aggcacagtc tcaaatgggt gtttttgatc tccttaatac atttggcggc 144301 ggtgcgcttt accaattttc cattttcgca atgggaatta ctccttatat cacggcttcg 144361 atcatcattc agctgcttca gatggatgtg gtaccgaagt ttaccgagtg gtctaagcaa 144421 ggtgaagttg gccgccgtaa attagctcag ttcacaaggt actttacgat tgtgcttggt 144481 ttcatccaag cgttaggtat gtcatatgga ttcaacaatc tggcaaacgg tatgctgatc 144541 gaaaaatccg gtgtatcgac atatcttatc attgctttag tgctcactgg cggaactgcc 144601 tttttaatgt ggcttgggga acaaattact tctcatggag taggcaacgg aatatcgatc 144661 attatcttcg cggggattgt gtctagtatt ccaaaaacaa ttgggcaaat atatgagact 144721 caatttgtcg gcagcaacga tcagttgttt attcatattg tgaaagtcgc acttcttgtg 144781 attgcgattt tagcagttat tgttggagtt attttcattc agcaagccgt acggaaaatt 144841 gcgattcaat atgctaaagg cacaggtcgt tcacctgctg gcggaggtca gtctacacac 144901 cttccattga aagtgaatcc tgcaggggtt attccggtaa tctttgcggt tgcgtttttg 144961 ataacgccgc ggacgatcgc gtcattcttt ggaacaaacg atgtgacaaa gtggattcaa 145021 aacaactttg ataatacgca tccggtgggt atggcgatat atgttgcgtt gattattgcc 145081 tttacgtact tttatgcttt tgtacaggta aaccctgaac aaatggctga taaccttaaa 145141 aaacagggtg gctatatccc gggggttcgt ccagggaaaa tgactcaaga tagaattacg 145201 agcattttgt atcgacttac gtttgtgggt tctatattct tagccgtgat ttccattctt 145261 cctatctttt tcattcaatt cgctggattg cctcaaagtg cacaaattgg cggaacatct 145321 ttgttaattg ttgtcggggt agccttggag acaatgaaac aactagaaag ccagttggtg 145381 aaacgaaact accgtggatt tatgaaaaac tagaggaaat ggatttatcc attccctctt 145441 aataaagaga ggacggggga aatccgaatg aacttagtct taatggggct tcctggtgcc 145501 ggtaaaggca cacagggcga acgaattgtt gaggattatg ggattcctca tatctcaaca 145561 ggagatatgt tccgtgctgc tatgaaagaa gaaacaccac tcggactcga agcaaaatct 145621 tatattgata agggagagct cgtacctgac gaagtcacaa tcggaattgt aaaagagaga 145681 cttggcaaag atgattgtga aagaggtttt cttctggacg gatttccgcg aacagtcgct 145741 caagccgaag ctcttgaaga aattcttgag gaatacggca agccgattga ttatgtcatt 145801 aacattgaag tcgacaaaga tgttctgatg gaacgtctga ctggacgcag aatttgcagt 145861 gtttgcggca caacctatca tttagtcttt aatccgccga aaacgccggg tatttgtgat 145921 aaagacggag gcgaactcta tcaacgggca gatgataatg aggaaacagt ctctaaacgg 145981 cttgaggtaa acatgaagca aactcagcct ttactcgatt tctattcaga gaaaggttat 146041 cttgcaaacg tgaatggcca gcaggacatt caagacgttt atgcagatgt gaaggatctt 146101 cttggaggat taaaaaaatg attatctgta aaaccccacg tgaacttggt atcatgcggg 146161 aagcagggcg aatcgtggct ttaactcatg aagagttaaa aaagcacatt aaaccaggaa 146221 tctcgacaaa agaattggat caaattgccg aacgttttat taagaagcag ggtgcaatcc 146281 catcttttaa ggggtataat gggtttcgcg ggagcatttg cgtatcagtt aatgaagaac 146341 tcgttcacgg catacctggc agcagggtgc tgaaggacgg tgacatcatc agtattgata 146401 tcggtgctaa attaaatggt tatcatggtg actctgcatg gacatatccg gtaggaaaca 146461 tcagcgatga tgacaaaaaa cttctggaag tgacagagga gtctttatat aaaggcttgc 146521 aggaagcaaa accaggtgaa cgtttgtcga atatttccca cgcaatacaa acgtatgtcg 146581 aaaatgagca gttttcagtt gttagggagt atgtcggaca tggtgttggt caagacttgc 146641 atgaggaccc gcaaattcct cattacggtc cgcccaacaa aggaccacgg cttaaacctg 146701 gcatggttct cgctattgaa cctatggtga acgctggcag ccgctacgtg aaaacattgg 146761 ctgataactg gacggttgta acggtagatg ggaaaaagtg tgctcatttt gaacatacga 146821 ttgcgattac ggaaacgggt tttgatatac tgacgagagt ctagatgatg aaaataattc 146881 cgaagacaga tgtttttcaa gcttgatagg gcagaaagct tgggtgaaca ttggcaagac 146941 cgaattcatc ttgcttcttg tcgttggaat tttaaccatc atcaatgtac taacagcaga 147001 cggagaaaag cgtacatttc attctcctaa gaaaaagaat atcaatcatt taacccttta 147061 tgattgcgta tctccggaag ttcagaacag tataaacgaa acagggcgtg tgacaaactt 147121 cttttgaaat ttgtcagaaa gcaagttact gatttgaaga agggagaaca cttgaatggc 147181 gaaagacgat gtaattgaag tggaaggtac tatagtcgaa acactgccaa acgcgatgtt 147241 caaagttgaa cttgaaaatg gccacactgt tttggctcat gtatctggta aaatccgcat 147301 gcacttcatt cgcattttac ctggagacaa agttacggta gaattatctc catatgactt 147361 aactcgtggc aggattacgt accgttacaa ataaagcact ccggaaactg aaggaggttg 147421 gaaacacatg aaagtgagac catcagttaa accaatctgc gaaaaatgta aagttattcg 147481 cagaaaagga aaagtaatgg tgatctgtga aaatccaaag cataaacaaa aacaaggata 147541 atttataagg aggtgcccag agaatggctc gtattgctgg tgtagatatc ccacgtgaca 147601 aacgtgttgt tatttcttta acatacatct tcggaattgg ccgcacaacg gctcagcaag 147661 ttttaaaaga agctggagtt tcagaagata ctcgtgtgcg cgatcttact gaagaagaac 147721 ttggtaaaat ccgtgatatt attgacaaac tgaaagtaga aggtgacctt cgccgtgaag 147781 tttctcttaa tatcaaacgt ctgatcgaaa tcggaagcta ccgcggaatc cgtcatcgca 147841 gaggattacc tgttcgcgga caaaactcta aaaacaacgc gcgtactcgt aaaggtccgc 147901 gtcgtactgt agctaacaag aaaaaataag taagggaggt tcttaaacaa tggctgctgc 147961 tcgtaaatct aacacgcgta aacgtcgcgt gaaaaagaat attgagtctg gaattgctca 148021 tattcgttca actttcaata acacgatcgt tacgatcact gacactcatg gtaatgctat 148081 ttcttggtct agtgccggag ctttaggatt cagaggttct cgtaaatcta ctccttttgc 148141 tgcgcaaatg gctgcagaaa cagctgctaa aggttcaatc gaacatggtc ttaaaactct 148201 agaggttact gttaaaggac ctggttcagg ccgtgaagct gcaatccgtg cacttcaagc 148261 tgctggacta gaagtcactg ctatcagaga cgtaactcct gttcctcata acggatgccg 148321 tccaccaaaa cgtcgccgcg tgtaatttgt ttgtatagat tttgtgtccc tgtcaataat 148381 gggttatgat acagttattt atgaaacgaa tgcaccgact cgttgcctga gcacatacgg 148441 gactaaacaa tggggaattt cggatggaat ctcatatgat tctattcgag gtttcgacgt 148501 tttgaaggag ggttttaagt aatgatcgag attgaaaaac caaaaatcga aacggttgaa 148561 atcagcgacg atgccaaatt tggtaagttt gtcgtagagc cacttgagcg tggatatggt 148621 acaactctgg gtaactcctt acgtcgtatc ctcttatcct cactccctgg tgccgctgta 148681 acatcaatcc agatagatgg tgtactgcac gaattctcga caattgaagg cgttgtggaa 148741 gatgttacaa cgattatctt acacattaaa aagcttgcat tgaaaatcta ctctgatgaa 148801 gagaagacgc tagaaattga tgtacagggt gaaggaactg taacggcagc tgatattaca 148861 cacgatagtg atgtagagat cttaaatcct gatcttcata tcgcgactct tggtgagaat 148921 gcgagtttcc gagttcgcct tactgctcaa agaggacgtg ggtatacgcc tgctgacgca 148981 aacaagagag acgatcagcc aatcggcgtg attccgatcg attctatcta tacgccagtt 149041 tctcgtgtat cttatcaggt agagaacact cgtgtaggcc aagttgcaaa ctatgataaa 149101 cttacacttg atgtttggac tgatggaagc actggaccga aagaagcaat tgcgcttggt 149161 tcaaagattt taactgaaca ccttaatata ttcgttggtt taactgacga agctcaacat 149221 gctgaaatca tggttgaaaa agaagaagat caaaaagaga aagttcttga aatgacaatt 149281 gaagaattgg atctttctgt tcgttcttac aactgcttaa agcgtgcggg tattaacacg 149341 gttcaagagc ttgcgaacaa gacggaagaa gatatgatga aagttcgaaa tctaggacgc 149401 aaatcacttg aagaagtgaa agcgaaacta gaagaacttg gactcggact tcgcaaagac 149461 gattgactag tttcccttgt gaactaggat tttcgtgtgt ttattattca gaaacagcat 149521 tccaataaag gaggggacat cacatgtcat acagaaaact aggacgtacg agtgcacagc 149581 gtaaagctat gcttcgtgat cttacaactg atttgatcat caacgaaaga atcgaaacaa 149641 ctgaaacacg tgcgaaagaa cttcgctctg tagttgaaaa aatgatcacg cttggcaaac 149701 gcggtgatct tcacgctcgc cgtcaagctg ctgcatacat ccgcaacgag gttgcaaacg 149761 aagaaaataa tcaagatgca cttcaaaaat tattctctga cattgcaact cgttacgagg 149821 agcgccaagg tggatacaca cgtattatga agcttggtcc tcgccgtggt gacggagcac 149881 caatggcaat tatcgaattg gtttaatcac atatttttgt gtatctaaag aagggcggga 149941 cagtttctaa ctggatctat gccctttttt tagatactgc aacttttaat agagagaaaa 150001 gcagagcatt agctgagagg aggccggttt tccatgaatc aaaatcagtt gatatcggta 150061 gaggatatcg tatttcgata tcggaaggac gcagaaagac gagcactaga cggcgtctcc 150121 ctgcaggtgt atgagggtga atggcttgca atcgtaggtc ataacggttc agggaaatca 150181 acactggccc gggcattgaa tggtttaatt cttcctgaat caggcgacat tgaggttgcc 150241 gggattcaat tgacagagga atctgtttgg gaagtgcgta agaagatagg tatggtcttt 150301 caaaatccgg ataaccaatt tgtcggaacg actgttcgcg atgatgtggc ttttggttta 150361 gaaaacaatg gtgtaccgcg ggaagaaatg attgagagag tagactgggc agtaaaacag 150421 gtgaatatgc aagattttct cgatcaagag ccgcaccatc tctccggagg ccaaaagcag 150481 agagttgcga ttgcgggggt tattgccgca cgtcctgata ttattatctt agatgaagca 150541 acatccatgc ttgatccgat cgggcgagaa gaagtgcttg aaacggtaag acatttaaaa 150601 gagcagggca tggcgactgt catatccatt acacatgacc tgaatgaggc agcaaaagca 150661 gacaggatca ttgtcatgaa tggcggtaaa aaatatgctg aagggccgcc tgaagagatt 150721 tttaaattga ataaagaact tgttcgaatt gggcttgatt tacccttctc attccagctt 150781 agccagcttt taagagaaaa tggactggct ttggaagaaa accatttgac tcaggaaggg 150841 ctggtgaaag agctgtggac attacaatca aagatgtaga gcatcgctat cagatgaaga 150901 ccccgtttga gcgcctagca ctgtatgata tcaatgcatc gattaaagaa ggaagctacg 150961 tagccgttat cgggcataca ggctctggca agtccactct tctacagcac ctaaatggtc 151021 tcctgaagcc gacgaaggga cagatatcac taggcagcac tgtcattcag gcagggaaaa 151081 agaataaaga tctgaaaaaa cttcgtaaaa aagtcggaat cgttttccaa tttcctgagc 151141 atcaattatt cgaagaaaca gttcttaaag atatttcatt cggaccgatg aactttggtg 151201 ttaaaaaaga agatgctgaa caaaaagcga gagagatgct gcagcttgta ggtttatcag 151261 aagagctttt ggacaggtca ccctttgaat taagcggggg acaaatgcgc agagttgcaa 151321 ttgccggcgt acttgcaatg gaccctgaag tgcttgttct ggatgaaccg actgcaggat 151381 tggacccaag agggcgaaaa gagattatgg acatgtttta tgagcttcat caacgtggga 151441 acttgacgac gatccttgtg acacacagca tggaggatgc agctgcatac gctgatgaaa 151501 tgattgttat gcataaagga acgatacaag catcaggcag tccgcgtgat ctgtttttaa 151561 agggtgaaga gatggccggc tgggggctgg atcttcctga aacaataaaa ttccaaagac 151621 accttgaagc tgcactgggt gtgagattta atgagcctat gctcacaatc gaagatgccg 151681 ctgccgaaat ccgtgctctt tttcagggag agaagacttt atgatggaca gcatgattat 151741 cggcaagtat gtaccgggga cttcacttgt gcaccggctt gaccccagaa caaaactgat 151801 cacgatcttt ttatttgtct gcattgtatt cttagccaat aatgttcaga catatgcgtt 151861 gcttggttta tttacaattg gcgtcgtttc tttaacaaga gttcctttct cttttttaat 151921 gaaagggctg aagccaatca tctggattgt cctttttacg ttccttcttc acattcttat 151981 gacacatgaa ggaccgatta tctttcaaat aggttttttc aaagtctatg agggcggtct 152041 ggttcagggg atattcattt ctcttagatt cgtctatttg attttaatca caaccttatt 152101 aacgcttacg actacaccga ttgagattac cgatggaatg gagcagctgc tgaacccatt 152161 gaaaaaatta aagcttcctg ttcatgagct ggctcttatg atgtcaattt ctttacggtt 152221 tattccgaca ctgatggagg agacagataa gatcatgaag gctcagatgg cgcgaggcgt 152281 tgattttaca agcgggcctg tcaaagaaag agtgaaggct attgtcccgc ttcttgtccc 152341 gctcttcgtc agcgcattta aacgcgccga agagcttgcg gtggcaatgg aagcaagagg 152401 ctatcaaggc ggagaaggac gtacgaaata tagaaagctt gtatggacag gaaaagacac 152461 ttctgtcatt gtcagcttaa ttgtattagc tgctttgtta tttttcttaa gggcttagag 152521 gtgctgtatg agactgaaat gcacgatttc ttatgacgga catttgttta acggttatca 152581 ggttcagccg ggcaaaagaa cggttcagga tgaactggag aaggctttgg ctgtcctgca 152641 taagtcaaaa gacagaattc cggtcgtttc gtctggaaga acagacagcg gggttcacgc 152701 agccggacag gtgattcatt ttgacactcc gctgtctatc ccggctgaga gatggccata 152761 tgccttaaat gcactgcttc cggacgatat cgcagtcaaa caggcagaaa ttgcggatga 152821 tgggttccat gcacgattta gcgcagtcaa aaaagaatat cgctactttg tatacacgga 152881 gaaacacccg gacgtattta aacggcatta cgcttaccat ttttcatatc gccttaatgt 152941 gcaggacatg agagaagcgg caaagcatct tatagggaca catgatttta cgagcttttg 153001 cgcggctaaa acagaagtgc aggacaaggt aagaacgata tacgaacttg attggactga 153061 gacggctgac ggcctgcaaa tgcggatcac aggcagcggt ttcttatata atatggtcag 153121 aattattgcg ggtactttgc ttgatgcagg tattggaaaa atttctcccg atgaggtgaa 153181 atccatgctg gaagcgaagg atcgcgaagc ggcagggcgc acagcgccgg ggcacgggct 153241 atatttatgg aacgtttact atgacaacta aaccaggtgt ataatatttt cttgacagag 153301 tctgcataaa gttataagat atcatatggt atgtatttca accccacgat aagccccgga 153361 acttattgtg ttgtgaaata gaacgtaatc gaagtttatt gaaaatgaca gatcatttag 153421 gagggaaatt caatgcgtac aacacctatg gctaacgcaa gtactattga acgcaagtgg 153481 ttagttgttg atgctgctgg caagacttta ggtcgtcttt cttcagaagt tgcagctatc 153541 cttcgcggaa aacacaaacc aacttacaca ccacacgttg atactggaga tcatgtgatc 153601 atcatcaacg ctgaaaaaat cgagttaact ggtaaaaagt taactgacaa aatctactac 153661 cgtcacactc aacatccagg cggattaaaa tcaagaactg ctcttgaaat gcgtacaaac 153721 taccctgaga aaatgcttga gcttgctatc aaaggcatgc ttccaaaagg ttctctaggt 153781 cgtcaaatgt tcaaaaaatt gaacgtatac cgtggttctg agcatccaca cgaagcacaa 153841 aaacctgaag tttacgaact tcgcggttaa ttaaaaagga ggttaccaat ttggcacagg 153901 ttcaatatta cggtactggc cgtcgtaaaa gctctgtagc gcgtgtgcgt ttagttccag 153961 gagaaggccg tatcgtcgtt aataatcgtg aaatcagcga acatatccca tctgcagctt 154021 taatcgaaga tatcaaacaa ccattaactt tgactgaaac agctggcact tatgatgttt 154081 tagtaaacgt acatggaggc ggcctatctg gtcaagctgg agcaatccgt cacggtatcg 154141 ctcgtgcttt gcttgaagca gatccagaat accgtacaac tcttaaacgt gcaggtcttc 154201 tgactcgtga cgctcgtatg aaagaacgta aaaaatacgg tcttaaaggc gctcgtcgtg 154261 cacctcagtt ctcaaaacgt taattttacg ttttcaaaaa gctctcgacc ttgggttggg 154321 agcttttttc tttcaataaa acgtggcagt cccgcataaa aataacaact gaatggacgc 154381 ttgacggggt taagcaaatt gtttgtttat aaacggtctc tttgtaataa tcatggtaga 154441 tttcattctt attcaattgg aagttcggtc aatgtttatt atcgttatgt gatcagccca 154501 gctccatcta accactgtat ctcatccgtt aaagttcact gctgattctt aacccggaga 154561 aacaatagct ctcattgcta atggctttat gtaacgaagt aaaagtaaat ctgatgatat 154621 aaatcacata tctcctttgt gatttttttg cgtttttatg aacttttttc taaatatgca 154681 aagggaaagc gatatcaatc tagaaatatt tgttatactc tatacattaa agtaaggaga 154741 agattcatga atgcgttagt agctcataat agcaaagcct gggataaaaa agtagaaaca 154801 ggcaatgaat ggactgttgc tgttgaacag caggttatcg aacaagcaaa aaaaggcaat 154861 tgggatataa gggtaacacc aatgaaagat gtaccgaagg attggtttcc gcctatcaaa 154921 ggtctgaaag tactctgttt agcatcaggc ggcggccagc agggtccagt tttggcagcc 154981 gcaggcgcgg atgtcactgt attagataac tcagaaaaac agctgaatca ggatagaatg 155041 attgctgagc gagatggtct gacgatacac actgtcaaag gaagcatgga cgatttaagt 155101 gtatttaatg atgaatcatt tgatgtcatt gtacatcctg ttgccaatgt ttttgttgag 155161 aatgtcctcc cggtatggaa ggaagcgtac cgtgtgttga aaaggaacgg cattctaatc 155221 tcgggttttg tcaatcctgt tgtatttctg tttgatacag aattagaaca gcaaggtgtt 155281 ttaaaagtaa aacactctat tccatacgct gacccagaag atcttccgaa acataaagtg 155341 aaaaaactga tcgaaaataa tgaggctctg gaattcggcc attccttaga agaccaaatc 155401 aaaggccaaa ttgatgccgg ttttatcgtt actggttttt atgaagataa aggcggtttt 155461 gtattagacc aatatatcca tacatattct gcaacaagaa gcgtgaaagt atgaaaagca 155521 gcgacctgtt agaggggctg cttttttcat aaccaattac agaacatttg ttcctcaccc 155581 tgcagaaagc tgatttttta tcaatgttac accttcattt gggcgaattt ccaaccgaat 155641 tcgggcattg tttcatcatc caaacctcaa aataatcggt aaaaggagag tgaatttata 155701 tggcagaagt actgtctttt atggatgtga aacgccaaaa ggattttgaa ttagaaaaga 155761 acttgctcaa agaactctct ctgagacaaa ttatccagtc tgttaaggat tgtttggaac 155821 cattatttcc atttttacat gatgaacgag atattattac cgaaggctgt attgattttg 155881 cgattgaagc ttatttgtta ggcgggcgtt ttgggatatt cggctattac ggagaatcaa 155941 tgcagagtat cagtgcccgc tctgcaagag aagaagaaga gctgcgtatg gagttttttg 156001 attatctcta taattggata cacgagcaat acgcaacatt tgataaaaac actgtttatg 156061 aagcggcacg caagttcatt aaagattggt ggacagcagg gtttgttcaa agagaaaaac 156121 agtgtaagct tcgcatgcgg taatcatatt tcccgaccct gtcccatagt tatgtaataa 156181 cggacaagcg ggaggggaag ggatgaggaa aaagcttaaa tggctcagtt ttttgctagg 156241 cttcatcata ttactatttc tgttcaagta tcagttcagc aataacgact cttggaagcc 156301 gtggagcctg cccttgagcg gtaaaatcat ttatctagat ccaggtcatg gcgggcctga 156361 cggcggagca gtcggcggaa agctgttaga gaaggatgtt accctggaag tggcctttag 156421 agtcagggat tatcttcaag aacaaggagc gcttgttatc atgaccagag aaagtgatac 156481 tgatctcgct ccagaaggaa caaaaggcta tagccgacga aaagctgagg atctaagaca 156541 acgagtcaaa ttaataaacc attcagaggc ggagctctat atcagcattc atcttaatgc 156601 gattccgtca caaaaatgga gcggagccca aagcttttat tacgggaaat atgcggaaaa 156661 tgagaaagtc gcaaaataca ttcaggatga gctgagaaga aatctggaaa acacaacccg 156721 gaaagcaaag cggattcatg gtatctactt aatgcaaaac gtcaccaaac cgggggcgct 156781 tatagaagtc ggatttttat ccaatccaag tgaagcaacg ttgctcggta aaccgaaata 156841 tcaagacaag gtggcatctt ccatatataa aggcattttg cgatatttca cagaaaaagg 156901 agaccctccg gagtaatgga gggttttctt gtggttctaa gcataagaca cccgccattt 156961 atgtatgata taataataat tgtaaacgaa tacacaaaag ggtgaggttc gatgataaga 157021 gaagatgaag taagaaaact agtcggagaa atgcgcgaac cttttcttca aagacctctg 157081 ggagaattgg atgccgttaa ggaaattaaa ataaagcctg aaaaacggca tatcagtgta 157141 aaagtcgctc ttgcaaaaac aggaactgca gaacaaatgc agattcagca agagatcgta 157201 aacgtattaa aaggggcagg agctgagaca gtcggccttc gatttgaaga gctgcctgaa 157261 gaaacggttg ctaaattccg ggcgccgtca gctgagaaaa aaacattatt aaatatggat 157321 aacccgccag tctttcttgc tgtagcaagt ggaaaaggcg gcgtaggcaa gtcaactgtg 157381 tcagtaaacc tagctatttc tctggctcgt ctagggaaaa aggttggttt aattgatgcg 157441 gatatttatg ggttcagtgt gccggacatg atgggtatca ctgtgcgtcc aacaattgaa 157501 ggagagaaac ttcttcctgt tgaacgcttt ggagtaaagg tcatgtcaat gggctttttc 157561 gtagaagaaa atgccccggt cgtatggaga gggccgatgc tcggcaaaat gctgaataat 157621 tttttccatg aagtagagtg gggagaagta gactatatcg ttcttgatct tccgcctggt 157681 acaggggacg ttgctctcga tgtacataca atgcttccga gctgcaaaga aattatcgta 157741 tctacgccac atccgacagc tgcttttgtc gcggccagag cgggctctat ggcgattaaa 157801 accgatcatg aggtcgtggg tgtcatagag aacatggctt attatgaaag tgcaaagaca 157861 ggggaaagag aatatgtgtt tggaaaaggc ggaggagata aactggctga ggaactaaac 157921 gtgcctttgc tcggcagaat cccattgaaa cagcccgatt gggataagga ccaatttgct 157981 ccgtctgttt atgacgaaaa tcatccaatc ggagaaatat atcaggacat cgcaaaaaaa 158041 atagatgcaa aaatgtcagt gcaggtataa aaggtgaacc gggattccag atcccggctt 158101 tccctttatt cactttcttt tgctgtgtct tttgctgctt ttttcagctc atcttcgaac 158161 tgctttttgt aaagcggact agaaagtgtt tcgttaataa cctcttctaa ataactgcgg 158221 aattcttggc tttttgccag ctggctgtac tttttatcca tgccgggatc ctgcataacg 158281 ctcatcagca tcttctggta atctggatcc ttcatcagct ttttaatcac tttttcatgc 158341 tctgtctgaa gagttttggc aaagccctca gcaaaatcag tgtcttcaaa gatgtttttc 158401 caaaattctt cacctttttt agatgtgagt gttttttcta ttgttccttt aattgcatct 158461 tggtcaatca ccagcgcttc attcatggca tcatcattta ataattcctt aatagctttc 158521 tttccatcat cagtttttaa tatatcaaca accatttttt tggtctgatc atagtccata 158581 tccgctgctt ggtcttttgg agcgcaagct gttacagata ataacaaaaa acagctcatc 158641 aatagcgttt tggcttttga catgcttaag ctcctttcac atacttgtct tacctttaat 158701 atgattcatc tgtttggaat tatacataac aaaatatcgc tgttcgcgat ttttgagggg 158761 atgaataaag aaatgaaaag ccgtggttta gttcgttttt tcttttctat tttagctgtc 158821 ggggcgctta tcacgagtat tgtgggtttt gctttaaagt ggggagaata tagagggctg 158881 tttctaacat ttgaagcggg acagattttc tctgttttat tttggtttat cggtgtaggc 158941 atgattttca gtgtgatcag ccaaatgggt tttttcgtgt ttttaacagt tcatcggttt 159001 gcgcttgaga tattaaggtc ctcctctttg tggaatttgc tgcagttgtt tttcatcctg 159061 tttgttgctt ttgatttaat gtacgtgcgt tttttatttt ttggagagag cggagaatcg 159121 ctggctggct atgcgtggtt accggtgttt ttattgatct ttggagtgat tacagcttat 159181 ataaagcaaa agcagtcctc taagaaaaca tttgtgtcat cgttattttt gatggttgtg 159241 attaccgcat tagaatggtt ccctgcatta agagtaaatg atgaggactg gctttattta 159301 atgctttttc cgttaatggc atgtaatgcc ttccaattgc tgatgctgcc gaagtttgca 159361 gcaaagtaat tactttacct ctgcggattt ggcatcagaa tttgcgatga gatcacccac 159421 ggttacattt tttaatcctt tttctttcag ctgatggatg atatcaggca atgcttcttc 159481 tgtttgtttt gcagaatcgg aggcatgtaa aagaataatg tctccaccgg aaacttgctt 159541 ggtcacattg tcgatgattt tttcaactcc gggatttgtc cagtcttgag agttcacact 159601 gtaatgaacg actgtataat tgtattgctt tgcgaccttt agaacattct tattgaattg 159661 gccggtaggg ggtcttaata gctgtatgtc tttgacccct aacttttcaa aggctgtttg 159721 cgcacggttc atgtcctttt ttatttcgct gctctctaaa ttggcatagt ttttataagc 159781 gtagcccatg ctcccgattt gatggccgtc ctttacgata cgggccactg tgtcgggatg 159841 gcgttctgcc caagaagcgg acaggaaaaa cgttgcgttt ttaatcccgt ttgctttcag 159901 agtattaagt atcggttctg ctctctcatc accccagctg atatcgaaag taagtgaaat 159961 atctttagag tctgtttctc ctttataaat ggctttaggt ccggtgtcag ttgaaaacac 160021 gggaagcggg acagctcttt ggatataaaa aaagctggca gctgcaaatg cggcgataag 160081 tataataatt aattgtttta cccgtttaat gtgccacaca tagaagtgat tcactgatga 160141 tgcctcctta tcttgtccat cattcttgtt ttacatctta tgagcatgga caattgaata 160201 taaccgataa aatgtctctt cacatacagc ctaaattggg tgttgacctt ttgataatat 160261 ccgtgatata ttattattcg tcgctgataa acagctgaca tcaactaaaa gcttcattaa 160321 atactttgaa aaaagttgtt gacttaaaag aagctaaatg ttatagtaat aaagctgctt 160381 cgttaagcgg cagtaatgat ctttgaaaac taaacaagac aaaacgtacc tgttaattca 160441 tttttataaa tcgcacagcg atgtgcgtag tcagtcaaac tactttatcg gagagtttga 160501 tcctggctca ggacgaacgc tggcggcgtg cctaatacat gcaagtcgag cggacagatg 160561 ggagcttgct ccctgatgtt agcggcggac gggtgagtaa cacgtgggta acctgcctgt 160621 aagactggga taactccggg aaaccggggc taataccgga tggttgtttg aaccgcatgg 160681 ttcaaacata aaaggtggct tcggctacca cttacagatg gacccgcggc gcattagcta 160741 gttggtgagg taatggctca ccaaggcaac gatgcgtagc cgacctgaga gggtgatcgg 160801 ccacactggg actgagacac ggcccagact cctacgggag gcagcagtag ggaatcttcc 160861 gcaatggacg aaagtctgac ggagcaacgc cgcgtgagtg atgaaggttt tcggatcgta 160921 aagctctgtt gttagggaag aacaagtacc gttcgaatag ggcggtacct tgacggtacc 160981 taaccagaaa gccacggcta actacgtgcc agcagccgcg gtaatacgta ggtggcaagc 161041 gttgtccgga attattgggc gtaaagggct cgcaggcggt ttcttaagtc tgatgtgaaa 161101 gcccccggct caaccgggga gggtcattgg aaactgggga acttgagtgc agaagaggag 161161 agtggaattc cacgtgtagc ggtgaaatgc gtagagatgt ggaggaacac cagtggcgaa 161221 ggcgactctc tggtctgtaa ctgacgctga ggagcgaaag cgtggggagc gaacaggatt 161281 agataccctg gtagtccacg ccgtaaacga tgagtgctaa gtgttagggg gtttccgccc 161341 cttagtgctg cagctaacgc attaagcact ccgcctgggg agtacggtcg caagactgaa 161401 actcaaagga attgacgggg gcccgcacaa gcggtggagc atgtggttta attcgaagca 161461 acgcgaagaa ccttaccagg tcttgacatc ctctgacaat cctagagata ggacgtcccc 161521 ttcgggggca gagtgacagg tggtgcatgg ttgtcgtcag ctcgtgtcgt gagatgttgg 161581 gttaagtccc gcaacgagcg caacccttga tcttagttgc cagcattcag ttgggcactc 161641 taaggtgact gccggtgaca aaccggagga aggtggggat gacgtcaaat catcatgccc 161701 cttatgacct gggctacaca cgtgctacaa tggacagaac aaagggcagc gaaaccgcga 161761 ggttaagcca atcccacaaa tctgttctca gttcggatcg cagtctgcaa ctcgactgcg 161821 tgaagctgga atcgctagta atcgcggatc agcatgccgc ggtgaatacg ttcccgggcc 161881 ttgtacacac cgcccgtcac accacgagag tttgtaacac ccgaagtcgg tgaggtaacc 161941 ttttaggagc cagccgccga aggtgggaca gatgattggg gtgaagtcgt aacaaggtag 162001 ccgtatcgga aggtgcggct ggatcacctc ctttctaagg atattatacg gaatataaga 162061 ccttgggtct tataaacaga acgttccctg tcttgtttag ttttgaagga tcattccttc 162121 gaaacgtgtt ctttgaaaac tagataacag tagacatcac attcaagtaa tacaagatat 162181 cacatagtga ttctttttaa cggttaagtt agaaagggcg cacggtggat gccttggcac 162241 taggagccga tgaaggacgg gacgaacacc gatatgcttc ggggagctgt aagcaagctt 162301 tgatccggag atttccgaat ggggaaaccc accactcgta atggagtggt atccatatct 162361 gaattcatag gatatgagaa ggcagacccg gggaactgaa acatctaagt acccggagga 162421 agagaaagca aatgcgattc cctgagtagc ggcgagcgaa acgggattag cccaaaccaa 162481 gaggcttgcc tcttggggtt gtaggacact ctgtacggag ttacaaagga acgaggtaga 162541 tgaagaggtc tggaaaggcc cgccatagga ggtaacagcc ctgtagtcaa aacttcgttc 162601 tctcctgagt ggatcctgag tacggcggaa cacgtgaaat tccgtcggaa tccgggagga 162661 ccatctccca aggctaaata ctccctagtg accgatagtg aaccagtacc gtgagggaaa 162721 ggtgaaaagc accccggaag gggagtgaaa gagatcctga aaccgtgtgc ctacaagtag 162781 tcagagcccg ttaacgggtg atggcgtgcc ttttgtagaa tgaaccggcg agttacgatc 162841 tcgtgcaagg ttaagcagaa gatgcggagc cgcagcgaaa gcgagtctga atagggcgca 162901 tgagtacgtg gtcgtagacc cgaaaccagg tgatctaccc atgtccaggg tgaagttcag 162961 gtaacactga atggaggccc gaacccacgc acgttgaaaa gtgcggggat gaggtgtggg 163021 taggggtgaa atgccaatcg aacctggaga tagctggttc tctccgaaat agctttaggg 163081 ctagcctcaa ggtaagagtc ttggaggtag agcactgatt ggactagggg cccctaccgg 163141 gttaccgaat tcagtcaaac tccgaatgcc aatgacttat ccttgggagt cagactgcga 163201 gtgataagat ccgtagtcga aagggaaaca gcccagaccg ccagctaagg tcccaaagta 163261 tacgttaagt ggaaaaggat gtggagttgc ttagacaacc aggatgttgg cttagaagca 163321 gccaccattt aaagagtgcg taatagctca ctggtcgagt gactctgcgc cgaaaatgta 163381 ccggggctaa acgtatcacc gaagctgcgg actgttcttc gaacagtggt aggagagcgt 163441 tctaagggct gtgaagccag accggaagga ctggtggagc gcttagaagt gagaatgccg 163501 gtatgagtag cgaaagaggg gtgagaatcc cctccaccga atgcctaagg tttcctgagg 163561 aaggctcgtc cgctcagggt tagtcgggac ctaagccgag gccgaaaggc gtaggcgatg 163621 gacaacaggt tgatattcct gtaccacctc ctcaccattt gagcaatggg gggacgcagg 163681 aggatagggt aagcgcggta ttggatatcc gcgtccaagc agttaggctg ggaaataggc 163741 aaatccgttt cccataaggc tgagctgtga tggcgagcga aatatagtag cgaagttcct 163801 gattccacac tgccaagaaa agcctctagc gaggtgagag gtgcccgtac cgcaaaccga 163861 cacaggtagg cgaggagaga atcctaaggt gatcgagaga actctcgtta aggaactcgg 163921 caaaatgacc ccgtaacttc gggagaaggg gtgctctgtt agggtgcaag cccgagagag 163981 ccgcagtgaa taggcccagg cgactgttta gcaaaaacac aggtctctgc gaagccgtaa 164041 ggcgaagtat aggggctgac gcctgcccgg tgctggaagg ttaagaggag cgcttagcgt 164101 aagcgaaggt gcgaattgaa gccccagtaa acggcggccg taactataac ggtcctaagg 164161 tagcgaaatt ccttgtcggg taagttccga cccgcacgaa aggcgcaacg atctgggcac 164221 tgtctcaacg agagactcgg tgaaattata gtacctgtga agatgcaggt tacccgcgac 164281 aggacggaaa gaccccgtgg agctttactg cagcctgata ttgaatgttg gtacagcttg 164341 tacaggatag gtaggagcct tggaaaccgg agcgccagct tcggtggagg catcggtggg 164401 atactaccct ggctgtattg accttctaac ccgccgccct tatcgggcgg ggagacagtg 164461 tcaggtgggc agtttgactg gggcggtcgc ctcctaaaag gtaacggagg cgcccaaagg 164521 ttccctcaga atggttggaa atcattcgca gagtgtaaag gcacaaggga gcttgactgc 164581 gagacctaca agtcgagcag ggacgaaagt cgggcttagt gatccggtgg ttccgcatgg 164641 aagggccatc gctcaacgga taaaagctac cccggggata acaggcttat ctcccccaag 164701 agtccacatc gacggggagg tttggcacct cgatgtcggc tcatcgcatc ctggggctgt 164761 agtcggtccc aagggttggg ctgttcgccc attaaagcgg tacgcgagct gggttcagaa 164821 cgtcgtgaga cagttcggtc cctatccgtc gcgggcgcag gaaatttgag aggagctgtc 164881 cttagtacga gaggaccggg atggacgcac cgctggtgta ccagttgttc tgccaagggc 164941 atcgctgggt agctatgtgc ggacgggata agtgctgaaa gcatctaagc atgaagcccc 165001 cctcaagatg agatttccca ttccgcaagg aagtaagatc cctgaaagat gatcaggttg 165061 ataggtctga ggtggaagtg tggcgacaca tggagctgac agatactaat cgatcgagga 165121 cttaaccata tttttgaatg atgtcacatc tgttatctag ttttgagaga acactctcaa 165181 tttgtttggt ggcgatagcg aagaggtcac acccgttccc ataccgaaca cggaagttaa 165241 gctcttcagc gccgatggta gtcgggggtt tccccctgtg agagtaggac gccgccaagc 165301 agatttatta attctaccat gtttgtttat gaagctttat attattccgc agtagctcag 165361 tggtagagct atcggctgtt aaccgatcgg tcgtaggttc gaatcctacc tgcggagcca 165421 ttgcttccat agctcagcag gtagagcact tccatggtaa ggaagaggtc agcggttcga 165481 gcccgcttgg aagcttaaat gtattattac caaggtttct cataaggaga aagctttttt 165541 tattgcgata tgcggaagta gttcagtggt agaacaccac cttgccaagg tgggggtcgc 165601 gggttcgaat cccgtcttcc gctccattta tcctaacggg atattgtaaa ttgaattgcg 165661 cccgtagctc aattggatag agcgtttgac tacggatcaa aaggttaggg gttcgactcc 165721 tctcgggcgc gccatatctt ttaatagaat agataggaaa tcgggaagta gctcagcttg 165781 gtagagcaca tggtttggga ccatggggtc gcaggttcga atcctgtctt cccgaccatt 165841 ttttatgggg ccttagctca gctgggagag cgcctgcttt gcacgcagga ggtcagcggt 165901 tcgatcccgc taggctccac caaaagtttt taaaaaagtt attgactttg aagaagtgac 165961 attgtatact aataaagttg ctttaacaaa gcggacaaac aaaatgatct ttgaaaacta 166021 aacaagacaa aacgtacctg ttaattcagt ttttaaaaat cgcacagcga tgtgcgtagt 166081 cagtcaaact actttatcgg agagtttgat cctggctcag gacgaacgct ggcggcgtgc 166141 ctaatacatg caagtcgagc ggacagatgg gagcttgctc cctgatgtta gcggcggacg 166201 ggtgagtaac acgtgggtaa cctgcctgta agactgggat aactccggga aaccggggct 166261 aataccggat ggttgtttga accgcatggt tcaaacataa aaggtggctt cggctaccac 166321 ttacagatgg acccgcggcg cattagctag ttggtgaggt aacggctcac caaggcaacg 166381 atgcgtagcc gacctgagag ggtgatcggc cacactggga ctgagacacg gcccagactc 166441 ctacgggagg cagcagtagg gaatcttccg caatggacga aagtctgacg gagcaacgcc 166501 gcgtgagtga tgaaggtttt cggatcgtaa agctctgttg ttagggaaga acaagtaccg 166561 ttcgaatagg gcggtacctt gacggtacct aaccagaaag ccacggctaa ctacgtgcca 166621 gcagccgcgg taatacgtag gtggcaagcg ttgtccggaa ttattgggcg taaagggctc 166681 gcaggcggtt tcttaagtct gatgtgaaag cccccggctc aaccggggag ggtcattgga 166741 aactggggaa cttgagtgca gaagaggaga gtggaattcc acgtgtagcg gtgaaatgcg 166801 tagagatgtg gaggaacacc agtggcgaag gcgactctct ggtctgtaac tgacgctgag 166861 gagcgaaagc gtggggagcg aacaggatta gataccctgg tagtccacgc cgtaaacgat 166921 gagtgctaag tgttaggggg tttccgcccc ttagtgctgc agctaacgca ttaagcactc 166981 cgcctgggga gtacggtcgc aagactgaaa ctcaaaggaa ttgacggggg cccgcacaag 167041 cggtggagca tgtggtttaa ttcgaagcaa cgcgaagaac cttaccaggt cttgacatcc 167101 tctgacaatc ctagagatag gacgtcccct tcgggggcag agtgacaggt ggtgcatggt 167161 tgtcgtcagc tcgtgtcgtg agatgttggg ttaagtcccg caacgagcgc aacccttgat 167221 cttagttgcc agcattcagt tgggcactct aaggtgactg ccggtgacaa accggaggaa 167281 ggtggggatg acgtcaaatc atcatgcccc ttatgacctg ggctacacac gtgctacaat 167341 ggacagaaca aagggcagcg aaaccgcgag gttaagccaa tcccacaaat ctgttctcag 167401 ttcggatcgc agtctgcaac tcgactgcgt gaagctggaa tcgctagtaa tcgcggatca 167461 gcatgccgcg gtgaatacgt tcccgggcct tgtacacacc gcccgtcaca ccacgagagt 167521 ttgtaacacc cgaagtcggt gaggtaacct tttaggagcc agccgccgaa ggtgggacag 167581 atgattgggg tgaagtcgta acaaggtagc cgtatcggaa ggtgcggctg gatcacctcc 167641 tttctaagga tattatacgg aatataagac cttgggtctt ataaacagaa cgttccctgt 167701 cttgtttagt tttgaaggat cattccttcg aaacgtgttc tttgaaaact agataacagt 167761 agacatcaca ttcaagtaat acaagatatc acatagtgat tctttttaac ggttaagtta 167821 gaaagggcgc acggtggatg ccttggcact aggagccgat gaaggacggg acgaacaccg 167881 atatgcttcg gggagctgta agcaagcttt gatccggaga tttccgaatg gggaaaccca 167941 ccactcgtaa tggagtggta tccatatctg aattcatagg atatgagaag gcagacccgg 168001 ggaactgaaa catctaagta cccggaggaa gagaaagcaa atgcgattcc ctgagtagcg 168061 gcgagcgaaa cgggattagc ccaaaccaag aggcttgcct cttggggttg taggacactc 168121 tgtacggagt tacaaaggaa cgaggtagat gaagaggtct ggaaaggccc gccataggag 168181 gtaacagccc tgtagtcaaa acttcgttct ctcctgagtg gatcctgagt acggcggaac 168241 acgtgaaatt ccgtcggaat ccgggaggac catctcccaa ggctaaatac tccctagtga 168301 ccgatagtga accagtaccg tgagggaaag gtgaaaagca ccccggaagg ggagtgaaag 168361 agatcctgaa accgtgtgcc tacaagtagt cagagcccgt taacgggtga tggcgtgcct 168421 tttgtagaat gaaccggcga gttacgatct cgtgcaaggt taagcagaag atgcggagcc 168481 gcagcgaaag cgagtctgaa tagggcgcat gagtacgtgg tcgtagaccc gaaaccaggt 168541 gatctaccca tgtccagggt gaagttcagg taacactgaa tggaggcccg aacccacgca 168601 cgttgaaaag tgcggggatg aggtgtgggt aggggtgaaa tgccaatcga acctggagat 168661 agctggttct ctccgaaata gctttagggc tagcctcaag gtaagagtct tggaggtaga 168721 gcactgattg gactaggggc ccctaccggg ttaccgaatt cagtcaaact ccgaatgcca 168781 atgacttatc cttgggagtc agactgcgag tgataagatc cgtagtcgaa agggaaacag 168841 cccagaccgc cagctaaggt cccaaagtat acgttaagtg gaaaaggatg tggagttgct 168901 tagacaacca ggatgttggc ttagaagcag ccaccattta aagagtgcgt aatagctcac 168961 tggtcgagtg actctgcgcc gaaaatgtac cggggctaaa cgtatcaccg aagctgcgga 169021 ctgttcttcg aacagtggta ggagagcgtt ctaagggctg tgaagccaga ccggaaggac 169081 tggtggagcg cttagaagtg agaatgccgg tatgagtagc gaaagagggg tgagaatccc 169141 ctccaccgaa tgcctaaggt ttcctgagga aggctcgtcc gctcagggtt agtcgggacc 169201 taagccgagg ccgaaaggcg taggcgatgg acaacaggtt gatattcctg taccacctcc 169261 tcaccatttg agcaatgggg ggacgcagga ggatagggta agcgcggtat tggatatccg 169321 cgtccaagca gttaggctgg gaaataggca aatccgtttc ccataaggct gagctgtgat 169381 ggcgagcgaa atatagtagc gaagttcctg attccacact gccaagaaaa gcctctagcg 169441 aggtgagagg tgcccgtacc gcaaaccgac acaggtaggc gaggagagaa tcctaaggtg 169501 atcgagagaa ctctcgttaa ggaactcggc aaaatgaccc cgtaacttcg ggagaagggg 169561 tgctctgtta gggtgcaagc ccgagagagc cgcagtgaat aggcccaggc gactgtttag 169621 caaaaacaca ggtctctgcg aagccgtaag gcgaagtata ggggctgacg cctgcccggt 169681 gctggaaggt taagaggagc gcttagcgta agcgaaggtg cgaattgaag ccccagtaaa 169741 cggcggccgt aactataacg gtcctaaggt agcgaaattc cttgtcgggt aagttccgac 169801 ccgcacgaaa ggcgcaacga tctgggcact gtctcaacga gagactcggt gaaattatag 169861 tacctgtgaa gatgcaggtt acccgcgaca ggacggaaag accccgtgga gctttactgc 169921 agcctgatat tgaatgttgg tacagcttgt acaggatagg taggagcctt ggaaaccgga 169981 gcgccagctt cggtggaggc atcggtggga tactaccctg gctgtattga ccttctaacc 170041 cgccgccctt atcgggcggg gagacagtgt caggtgggca gtttgactgg ggcggtcgcc 170101 tcctaaaagg taacggaggc gcccaaaggt tccctcagaa tggttggaaa tcattcgcag 170161 agtgtaaagg cacaagggag cttgactgcg agacctacaa gtcgagcagg gacgaaagtc 170221 gggcttagtg atccggtggt tccgcatgga agggccatcg ctcaacggat aaaagctacc 170281 ccggggataa caggcttatc tcccccaaga gtccacatcg acggggaggt ttggcacctc 170341 gatgtcggct catcgcatcc tggggctgta gtcggtccca agggttgggc tgttcgccca 170401 ttaaagcggt acgcgagctg ggttcagaac gtcgtgagac agttcggtcc ctatccgtcg 170461 cgggcgcagg aaatttgaga ggagctgtcc ttagtacgag aggaccggga tggacgcacc 170521 gctggtgtac cagttgttct gccaagggca tcgctgggta gctatgtgcg gacgggataa 170581 gtgctgaaag catctaagca tgaagccccc ctcaagatga gatttcccat tccgcaagga 170641 agtaagatcc ctgaaagatg atcaggttga taggtctgag gtggaagtgt ggcgacacat 170701 ggagctgaca gatactaatc gatcgaggac ttaaccatat ttttgaatga tgtcacacct 170761 gttatctagt tttgagagaa cactctcaat ttgtttggtg gcgatagcga agaggtcaca 170821 cccgttccca taccgaacac ggaagttaag ctcttcagcg ccgatggtag tcgggggttt 170881 ccccctgtga gagtaggacg ccgccaagca attgcacatt agtgtaattt tttaaaaaag 170941 ttattgactt tgaagaagtg acattgtata ctaataaagt tgctttaaca aagcggacaa 171001 acaaaatgat ctttgaaaac taaacaagac aaaacgtacc tgttaattca gtttttaaaa 171061 atcgcacagc gatgtgcgta gtcagtcaaa ctactttatc ggagagtttg atcctggctc 171121 aggacgaacg ctggcggcgt gcctaataca tgcaagtcga gcggacagat gggagcttgc 171181 tccctgatgt tagcggcgga cgggtgagta acacgtgggt aacctgcctg taagactggg 171241 ataactccgg gaaaccgggg ctaataccgg atggttgttt gaaccgcatg gttcaaacat 171301 aaaaggtggc ttcggctacc acttacagat ggacccgcgg cgcattagct agttggtgag 171361 gtaacggctc accaaggcaa cgatgcgtag ccgacctgag agggtgatcg gccacactgg 171421 gactgagaca cggcccagac tcctacggga ggcagcagta gggaatcttc cgcaatggac 171481 gaaagtctga cggagcaacg ccgcgtgagt gatgaaggtt ttcggatcgt aaagctctgt 171541 tgttagggaa gaacaagtac cgttcgaata gggcggtacc ttgacggtac ctaaccagaa 171601 agccacggct aactacgtgc cagcagccgc ggtaatacgt aggtggcaag cgttgtccgg 171661 aattattggg cgtaaagggc tcgcaggcgg tttcttaagt ctgatgtgaa agcccccggc 171721 tcaaccgggg agggtcattg gaaactgggg aacttgagtg cagaagagga gagtggaatt 171781 ccacgtgtag cggtgaaatg cgtagagatg tggaggaaca ccagtggcga aggcgactct 171841 ctggtctgta actgacgctg aggagcgaaa gcgtggggag cgaacaggat tagataccct 171901 ggtagtccac gccgtaaacg atgagtgcta agtgttaggg ggtttccgcc ccttagtgct 171961 gcagctaacg cattaagcac tccgcctggg gagtacggtc gcaagactga aactcaaagg 172021 aattgacggg ggcccgcaca agcggtggag catgtggttt aattcgaagc aacgcgaaga 172081 accttaccag gtcttgacat cctctgacaa tcctagagat aggacgtccc cttcgggggc 172141 agagtgacag gtggtgcatg gttgtcgtca gctcgtgtcg tgagatgttg ggttaagtcc 172201 cgcaacgagc gcaacccttg atcttagttg ccagcattca gttgggcact ctaaggtgac 172261 tgccggtgac aaaccggagg aaggtgggga tgacgtcaaa tcatcatgcc ccttatgacc 172321 tgggctacac acgtgctaca atggacagaa caaagggcag cgaaaccgcg aggttaagcc 172381 aatcccacaa atctgttctc agttcggatc gcagtctgca actcgactgc gtgaagctgg 172441 aatcgctagt aatcgcggat cagcatgccg cggtgaatac gttcccgggc cttgtacaca 172501 ccgcccgtca caccacgaga gtttgtaaca cccgaagtcg gtgaggtaac cttttaggag 172561 ccagccgccg aaggtgggac agatgattgg ggtgaagtcg taacaaggta gccgtatcgg 172621 aaggtgcggc tggatcacct cctttctaag gatattatac ggaatataag accttgggtc 172681 ttataaacag aacgttccct gtcttgttta gttttgaagg atcattcctt cgaaacgtgt 172741 tctttgaaaa ctagataaca gtagacatca cattcaagta atacaagata tcacatagtg 172801 attcttttta acggttaagt tagaaagggc gcacggtgga tgccttggca ctaggagccg 172861 atgaaggacg ggacgaacac cgatatgctt cggggagctg taagcaagct ttgatccgga 172921 gatttccgaa tggggaaacc caccactcgt aatggagtgg tatccatatc tgaattcata 172981 ggatatgaga aggcagaccc ggggaactga aacatctaag tacccggagg aagagaaagc 173041 aaatgcgatt ccctgagtag cggcgagcga aacgggatta gcccaaacca agaggcttgc 173101 ctcttggggt tgtaggacac tctgtacgga gttacaaagg aacgaggtag atgaagaggt 173161 ctggaaaggc ccgccatagg aggtaacagc cctgtagtca aaacttcgtt ctctcctgag 173221 tggatcctga gtacggcgga acacgtgaaa ttccgtcgga atccgggagg accatctccc 173281 aaggctaaat actccctagt gaccgatagt gaaccagtac cgtgagggaa aggtgaaaag 173341 caccccggaa ggggagtgaa agagatcctg aaaccgtgtg cctacaagta gtcagagccc 173401 gttaacgggt gatggcgtgc cttttgtaga atgaaccggc gagttacgat ctcgtgcaag 173461 gttaagcaga agatgcggag ccgcagcgaa agcgagtctg aatagggcgc atgagtacgt 173521 ggtcgtagac ccgaaaccag gtgatctacc catgtccagg gtgaagttca ggtaacactg 173581 aatggaggcc cgaacccacg cacgttgaaa agtgcgggga tgaggtgtgg gtaggggtga 173641 aatgccaatc gaacctggag atagctggtt ctctccgaaa tagctttagg gctagcctca 173701 aggtaagagt cttggaggta gagcactgat tggactaggg gcccctaccg ggttaccgaa 173761 ttcagtcaaa ctccgaatgc caatgactta tccttgggag tcagactgcg agtgataaga 173821 tccgtagtcg aaagggaaac agcccagacc gccagctaag gtcccaaagt atacgttaag 173881 tggaaaagga tgtggagttg cttagacaac caggatgttg gcttagaagc agccaccatt 173941 taaagagtgc gtaatagctc actggtcgag tgactctgcg ccgaaaatgt accggggcta 174001 aacgtatcac cgaagctgcg gactgttctt cgaacagtgg taggagagcg ttctaagggc 174061 tgtgaagcca gaccggaagg actggtggag cgcttagaag tgagaatgcc ggtatgagta 174121 gcgaaagagg ggtgagaatc ccctccaccg aatgcctaag gtttcctgag gaaggctcgt 174181 ccgctcaggg ttagtcggga cctaagccga ggccgaaagg cgtaggcgat ggacaacagg 174241 ttgatattcc tgtaccacct cctcaccatt tgagcaatgg ggggacgcag gaggataggg 174301 taagcgcggt attggatatc cgcgtccaag cagttaggct gggaaatagg caaatccgtt 174361 tcccataagg ctgagctgtg atggcgagcg aaatatagta gcgaagttcc tgattccaca 174421 ctgccaagaa aagcctctag cgaggtgaga ggtgcccgta ccgcaaaccg acacaggtag 174481 gcgaggagag aatcctaagg tgatcgagag aactctcgtt aaggaactcg gcaaaatgac 174541 cccgtaactt cgggagaagg ggtgctctgt tagggtgcaa gcccgagaga gccgcagtga 174601 ataggcccag gcgactgttt agcaaaaaca caggtctctg cgaagccgta aggcgaagta 174661 taggggctga cgcctgcccg gtgctggaag gttaagagga gcgcttagcg taagcgaagg 174721 tgcgaattga agccccagta aacggcggcc gtaactataa cggtcctaag gtagcgaaat 174781 tccttgtcgg gtaagttccg acccgcacga aaggcgcaac gatctgggca ctgtctcaac 174841 gagagactcg gtgaaattat agtacctgtg aagatgcagg ttacccgcga caggacggaa 174901 agaccccgtg gagctttact gcagcctgat attgaatgtt ggtacagctt gtacaggata 174961 ggtaggagcc ttggaaaccg gagcgccagc ttcggtggag gcatcggtgg gatactaccc 175021 tggctgtatt gaccttctaa cccgccgccc ttatcgggcg gggagacagt gtcaggtggg 175081 cagtttgact ggggcggtcg cctcctaaaa ggtaacggag gcgcccaaag gttccctcag 175141 aatggttgga aatcattcgc agagtgtaaa ggcacaaggg agcttgactg cgagacctac 175201 aagtcgagca gggacgaaag tcgggcttag tgatccggtg gttccgcatg gaagggccat 175261 cgctcaacgg ataaaagcta ccccggggat aacaggctta tctcccccaa gagtccacat 175321 cgacggggag gtttggcacc tcgatgtcgg ctcatcgcat cctggggctg tagtcggtcc 175381 caagggttgg gctgttcgcc cattaaagcg gtacgcgagc tgggttcaga acgtcgtgag 175441 acagttcggt ccctatccgt cgcgggcgca ggaaatttga gaggagctgt ccttagtacg 175501 agaggaccgg gatggacgca ccgctggtgt accagttgtt ctgccaaggg catcgctggg 175561 tagctatgtg cggacgggat aagtgctgaa agcatctaag catgaagccc ccctcaagat 175621 gagatttccc attccgcaag gaagtaagat ccctgaaaga tgatcaggtt gataggtctg 175681 aggtggaagt gtggcgacac atggagctga cagatactaa tcgatcgagg acttaaccat 175741 atttttgaat gatgtcacac ctgttatcta gttttgagag aacactctca atttgtttgg 175801 tggcgatagc gaagaggtca cacccgttcc cataccgaac acggaagtta agctcttcag 175861 cgccgatggt agtcgggggt ttccccctgt gagagtagga cgccgccaag caagcttaaa 175921 cccagctcat tgagctgggt tttttgtttt atatctgtgc cgatttgctt tcgtcagtat 175981 ccattttatc aagcttctgc tttttaaagt tttctaatac ttttgaattc caatacaatc 176041 cctagcatga tcaacatgag agtcataaat aatcaaaatg cagtttgtac gggagactca 176101 tccagactcc atccgactgc gattggcagg atagagccgc caatccattg gcagcgaaca 176161 gcatgcttgt cgtttgttct gtttttccat gataaaattg attggtgaca ataaaataat 176221 ggcgaacatg ccggccataa ataagtccta agaaaaaact aagaataatc cctgcaaaag 176281 ctgttttatt gattgccaaa atacagagtt aaatgaggcc gctcatattt atcagcctga 176341 gataatgatg ataggttatt ttttcggaaa ccagctcggg ttgccaaatg agagaaaaga 176401 tattactgtc attaaaacga ttcttggttt catccggata tgataaaatg tctcagacta 176461 tatttgagcc atttttttct tcagcaatca tcttgcgtaa ttgataaaaa tttattatga 176521 tactctttgt atgacaactc cttgcctcaa tacaatatac tcaacgtttc cccgttttct 176581 ccggtcgttt ttcttttcat tttctcccgt aaaataaaaa aagctcccaa tacaatagat 176641 atggtgcgga tttatttttt actaaaaagg agtcgttata tttgaataat agttttacat 176701 taaaacagca atggttcggg aatatccgaa aagacattct tgctggcatt ttagttgcgt 176761 tagcgttaat acctgaagcg attggctttt ctattatagc cggtgtggat ccgatggtcg 176821 gtctttatgc gtcattttgc atagccatta ttatttctat ttttggtggc agacctggca 176881 tgatttcagc tgcgacaggc tcaatggcag tcgttatggt gtcgctggtt gctgatcatg 176941 ggcttcagta tttatttgcg gctacgattt tgacaggcat tattcaggtg attttaggta 177001 tcagtaaaat tgcaagatta atgaaattca tcccgcgttc tgtgatgatc gggtttgtga 177061 atgcgctggc gatccttatc ttctctgcgc agcttcccca gtttgaaggt gcttcttgga 177121 gcatgtatgc gatgcttgcc gggtcgttgg ttattattta tgtgctgcca aggtttacga 177181 ctgctgttcc gtctccgctt gtggcgatta ttgtgatgac aattattgcg gtcactttcc 177241 atgtggatgt gcggacggtt ggtgatatgg gcaatatttc tagttcattg cctcatttct 177301 taatccctga tgttccgttt acctttgaaa cactgcaaat tatttttcct tattcaattg 177361 ctttagcgtt tgtcgggttg cttgaatctt tgctgacagc acagattatt gatgaaatga 177421 cggatacgga tagtgataaa aataaagaga gccgcggaca gggaattgcg aatatcgtga 177481 ctggattctt tggcggaatg gcaggctgcg ctatgatcgg acaatctgtc attaatacaa 177541 aagcgggcgg tcgcggacgt ttgtcagcat ttgttgccgg tgcttttctg atgtttttaa 177601 ttgcggtgtt aagtcatgtc gtggtgaaaa tcccaatggc ggcgttagta gctgtaatgg 177661 ttatggtgtc tgtcggcact tttgattggt cttctttaaa aggtctcaaa aaagcgccgc 177721 tcacggactc gattgtcatg gttgtgactg tggttacggt tgttgtgacg gatgacttat 177781 ctaagggtgt atttgtcggt gttcttttaa gtgccgtgtt ctttgtagca aaaatctcga 177841 agctgaaaat cgtttctcat gcagaggatc aaaagcttag aacgtatcaa gtgaaggggc 177901 aaatcttttt tgcgtcagtg actgatctta cgaatgcgtt tatatatcaa gaggatattg 177961 agcgggttgt gattgactta actgaagctc acgtatggga cgattctggt gcggccgcac 178021 ttgataagat tgttgcgaag tttaaggaac aaggcattga agctgagtta aaaggtttga 178081 ataaagcgag taaatctcta atgaaacaga tggcataaaa tagagaagcc cagatgaatg 178141 agatctgggc ttttttatat aacatacact taagcagcat tgatataata gagagaagag 178201 aaattttaaa taggggactt gcatatgatg cttcagaagc tgaaccgtgt attggggaga 178261 gtgatgccgc tgttaacgcc gactagtgtg gtgctgggcg tgctgctgtc tcagttttta 178321 aatgggtatg aatgggctgt gccttggatc tttgctttta ttacgtttgc aggcagtttg 178381 agcgcgaact ttcaatcttt gagacatgca ttgtctcatc ctctccctat gattcttgca 178441 ctattcgttc ttcatatttt catgccgctt tttgcttggg gcagcggcca tcttatattt 178501 aaaggtgatc ctttgacgat taccggttta acattggctg ttgtgattcc tacggggatt 178561 acaagcttga tttgggcagc gatgtacaaa gggaatgtcg gtttgacact ttcgattatt 178621 ttagttgata ctgtgctgtc accgctaatc gtaccgctga gtctttcatt gctggccggc 178681 gctcaggttc acatggatgt gtggggaatg atgaaaggtc tgattgtaat ggtcgtgatt 178741 ccttcttttt tgggcatgct gtttaatcag atgtcatctc cagaaagaac tgcgtttgtg 178801 agcagtgcgc tgtcgccttt ttcaaagctt tgcttgatgg cagtgattgc gattaacagt 178861 tcagcgattg ctccttattt caaatccatt gatttgagat ttgcaggaat agctgtaacg 178921 gtattcttta tcgcgttaac aggttatgcc gctgcttggc tgatcggaaa aatgatgaaa 178981 aggcggcaag aggaaatagt ctctcttata tttacgggag gcatgaggaa tattagtgcc 179041 ggcgcagttc ttgccgttac gttcttcccg tctcaggttg ccgttcctgt tgtgatcggc 179101 atgctgtttc agcagatatt ggctgctttg tttggctata tgctgaatcg ttttgaatta 179161 aaaccaatgt tgcagaaggc ataaaaaaac cgctcatagg gttgagcggt tttttccgta 179221 tagccattcg agcgcgttga tgaactgttt gcagaaatac ttgtggtggt gcaccgctcc 179281 tttttcaatt gaaagacaca actggtcttc agtgaagcct ttttctttta gactttgatg 179341 aacttgcttt gtttttttca gcatatgtcg ctgaatggat tgtttttcac ggccttcttc 179401 actcccgata gacatgaaaa cacgtgcagt gccgggcttt aaagaagata tatgaatggt 179461 ttccgctgcg ttctcgtacc agtatgaacc tgatatagag cctattttcc cgaacattga 179521 cggatatttt aatatggcga acattgagat gaggccgcct aatgaggcac cgatcattcc 179581 tcttgactgc ggttccctgg tgacgttcca gttttcttcg attagcggaa tgaactggtt 179641 cgttatatca gacagatagt gatatcccat tccgccgaag tccgtgaacc gatcactgag 179701 tgatgcagcc ggccatgggg tgtattcatc aagccggttt tcgggttcga taccgatcag 179761 cacgagttca gggagccttt gctgttgaaa ggcgctttct agtaattcga tttggttttg 179821 gaacaaagaa ctgccatcct gcacgtaaac agcaggaaat cccccgctgt ctgtgctgta 179881 ggaaggaggg aggtacagcg tgaacctcct gttgccggct ttgtgttctg aaagagatcc 179941 tttcaagcat tctccccctt tttttgcttg aaaagcagat ataagaaata aggaactccg 180001 aggatcgcca aaatgatgcc tgcgggcact tctgcgggct gaaaaaacag ttttccggca 180061 aagtctgcgc ttatcacaag aagcatcccg attaaaccgc tcagtggcag gatatagcga 180121 tgttcgacgc cagccagtct ccgtgagata tggggagcaa ttaagccgac aaacgccata 180181 cttcccgcta cggagacaca ggcgctgatg attgctacac aggcaacgag aaggatggtt 180241 ttttctttat ttgatgaaat accgaggctt ctgactgtgt cttcatcaaa acgaatggtg 180301 tcgagcaggc gggatttgcc gataagaatc ggtataaaca gcagcatcca tgggagtaca 180361 gctgtaatat acgtccagtt ggcagaccag atgcttccgt ttttccacac catggccatt 180421 tgatagtctt gcgggtccat ttttaaagat aaaaacaaag acagggcgct gaatcctgaa 180481 ttgatcgcaa tccctaccaa aataattctt cctgaatcta aattgcctct gtgccatgca 180541 aatatgtaaa tcaggatcgc cgcgatgagc ccgcctatca atccaaagag cggcattccc 180601 atcgctgcag ctatggatgt cacttccttc tggccttgga ataagagcat aaacgctaca 180661 atgccagctc ctgcccctgc gttgattccg agaattccag ggtcagcaag cccgtttctc 180721 gtgatggcct ggataacagc gcctgcaatg ccaagaccga gtccaataat agcagccatg 180781 acaacccgcg gcagtcttaa atcgaacagc aaaatttcat actgcggatt cgggtcgatt 180841 tgaaaaagag tggagagcag ctcagcagga cgaacagaaa atgatccgct cgttaagctg 180901 aaatagctga caacaagaat caaagcgatg aacaatgcat attttttagc cattttgctc 180961 ccctcctttt cgtttaatta aataaaggaa gaaaggtacg ccgataatgg atgttacgac 181021 ctcaatcggt gtttcaaacg gatagttgat aaatctgctt gcgagatcac acagggttaa 181081 aaagattccg cccaaaatac aggaacacgg aatcagcctg ctgtaatcag agccgacgag 181141 aaatctcgtg atatgcggaa caaccaaccc gacaaacgca atttttccgg ccagcgctac 181201 ggcactgccg gttagaatga tgacggaaag catcgccatg attttaatgg tttttttctt 181261 ttgccccagg cttttagaaa tgtcgtcccc taatgataca gcggttacct ttttgctgag 181321 agaaatggcc attataatgc caatcaggaa aaacggagcg gcaagcttca ggaaatctgg 181381 actcatttga tgaagtctgg cactgtacca gaaactgaga tcctgagaaa tttgaaaata 181441 aatcgacatg gccgctgata agctgctgag cagcatgctt gtgactgtgc cgatgatggc 181501 gagctgcacg ggggtaaatc cgtttggcat catggcggca aggccgaata ctaacaccgc 181561 tcctaacgct gagccgataa aagagtatat catcatttca atcgaagatg attgcgggag 181621 cagaaccatg caaagcgtaa tgataaacgc tgaaccatct gaaacaccca taatggatgg 181681 cgaagctaaa taattgcgcg taatgccctg cataagcgct ccagaaacag caagggctgc 181741 ccctatgagc agagcgccgg cagcccttgg aatccgggaa tgccatataa tttgatggtc 181801 tgtgtttccc ggatcgaaat gaataagaga tgtaaaaaca atatctgtgc tgagatgctt 181861 tgccccataa aggattgaaa gcaaaagtga cagcgctata gcaaatggag aagtaatcaa 181921 tatgatacgt gtccactgtt ttgaatacat acaaaaacct actctgaatt agttttgtgt 181981 caatttttca gcagccgctt tcaggaaacg gactttgctc caagctgtgc cgccttgtgc 182041 gagagggtcc actgagttga catacacatg gtcttctttg actgctttaa ggcttttcca 182101 gattggattt ttctctaaat cttttaaggc atcaggtttg tctgcatttt catcatcaga 182161 aaattggacg aaaatatggt ccgggttcat ttcacttaat ttttctaatg aactcagctc 182221 ttgcgctttt gcagccttta cttcgttcgg cgccttaagg cctaaatcac cgtatagtgt 182281 ggagttgaaa tacacctgtt cagggtaaat gtaaatgttg ccttgtctga ttctgatgac 182341 aagcgctttt gaatctttcg ctttatcgtt gatttttgtt tttatttctt ttagatcctg 182401 ttcatagtct gcaataattt tctttgcttt tttctctttt ccagtcagct gggcaagaag 182461 catcatgttt tccttccagt ttgaagagat atgagaaact gggatcgtcg tgcctgctgt 182521 gctgattttt tgcagcgttt tttccggaaa ctttgttgaa gcaaggataa catctggctt 182581 catttcaaga atcttttcaa tatttggctc cattttttct ccggttggtt cggctttatc 182641 agtgatgtct ttgaacatat cagggaattt gccggagaat gaaattgcgc cttgcggatg 182701 aacgtcaagc aatttcgcgt cttccattga ttcaacgctt cccgtaatgg caattttgtc 182761 tgtcggtaca gttacttcat atgttttatc aaggtattca attttcttct tctcagatgc 182821 tgtgccgctt gccttgctgg cagttgattc atttttgctg ccgcaagctg ccgccgtcag 182881 cgcgagaagt aagattaata aggtaagaga tatctttttc atctatagag cctcctgttc 182941 aattgataac tattatcaat tggaattata gagaatgaac agatataaca ccatggacaa 183001 attcctgatt tatcatggac aatctccgga tagtaaagaa acagtttgct gaacgatgcg 183061 ttcgtgcccg caagctgagt attcattcca cgggtcaagg gatagaagat aaacacggtt 183121 atctcgtacc gcgcttaggt tttgccatgc ttctgtctgc tgtaattgct ggtagtaagc 183181 tatggtctcc ggctctttaa aaagaaaaag catcatacag tcagcttggt aatttgcgat 183241 attttctaac gaaatcgctt gttctgaagg tgtgtcagcc gttgttgccg agctgaatcc 183301 taaatcccca aagaaaactt cgcggacact tcggttatga gccagataga agttttgctt 183361 atgcagcctc aaaaagagaa aacgcagccc ttgaacgtgc tgaagtgttt ttttggcggc 183421 cgttgtctgc tggtcataat ccgctagcca cttttctgct tcggactcct cctttaaaaa 183481 tgaggcagtt tgcagaaagt gggttctcca gctttcttct gaaggaaggt acatgacttc 183541 tgcgatgcga ttcaggcgat cttgttcttc tggagaaata gaatccatgc tgacaatcac 183601 atctggttct gcctgtgata acgtgtacag gttttcttcc cacttttcat taaaccggta 183661 tgcactgagc tggacgggta tatctgtcga ataatgctga tagtagtaag acgtccattt 183721 cggatgcaga gcggccgcaa aaggtatgtg gtgaagaggg atgagatggc ccattgtgcc 183781 ccttccgtat gcggcgattt tctttcggcg ttttttcata tagcttgtag gtgaacagcc 183841 tgtatatttt ttaaagattc tgctgaaata aaattcatct tgataaccgg tttggtgtgc 183901 gatttctttc aatttgcagt ttgattttgc catgagccgt tttgcctttg tgattcgtgt 183961 tttcgtaata aattctgtta cgctctgtcc tgtccatttt ttaaagcttt cactgtagtg 184021 tttggcactg attcctgcca tttgcgacag ctgggcaagc gtgatttttg tatcggcatg 184081 ggtttcgata tagtgttttg ttttttcgat tgctgaatgt gtatccgttt gatcagataa 184141 actggcagta aaaagatcat aaatcaggct ttgtacttca atcacacatt ttagctgaga 184201 aagctgagac gattcattcc atagtgcggc aagctcttga agccggactg caagattttc 184261 gatatgtgaa acattcataa gcttcagttt ggctaattcc gattctgtgc acggtgtgaa 184321 aatatcttgc ccggtttcct tgatatagct tagaagcctg attatacagg catctatatg 184381 tccatcggct gctggcgtaa agccaaaggt ctcgttaggc ggacaaacat aaagtgtctt 184441 tttttgcaga ggattggtgt ttgttccgat cgaaatatag ccgtttcctt ttaaatgaaa 184501 aatcagcacg aatgaatcgg ctaattgctg ttctgagaag agatcacttg tcttttttag 184561 atattcaatt tgtactggtt gataaatcac tgcattttgc acgagtagac caccttttca 184621 gaagctttca attgataatc attttcaata aaaattgtac caaataaatg aaagttttcc 184681 tatataaagc gggtgggttt ttagcatgaa aaaaaccctt acttatgtgt aaaagtaagg 184741 gtctttcgtt caataagaat atgttacacg tgtaacatac gatgcttatg ttctaataaa 184801 tgagatactt ttttcttgtt ttgctgaatt gttggagtgt tttttcatag ctgtttatga 184861 tgttctcaac cgaagttcca ttttcaattt ttgtcctgat ccagccgttg cctgccagtt 184921 tatcgaatga acctgttgac aggaactcaa aatcctcagg atagagatcg tgtatggttt 184981 taatgactga aagacccgtt ttaacggctt caaacttatc tctgtctgtc acatagagct 185041 gcacaccgtg gcaaagcgtt ccttgatgtt tagaaaacgt cggtgtgaag gatgctgccc 185101 taaatgtaac gcccggcaaa tggaggctgt ttaatgtttc ttcaagttct gtgcttttga 185161 taaagggagc tccgatcaat tcgaatggct ttgttgtccc tcgcccttcg gatatatttg 185221 ttccttcaat cagcccggtt gcaggataaa caaatgtgct ttccaccgtc ggcatgttag 185281 gcgaagggag gacgaaaggc aatcgggtat cgtcaaaatc catttttcgt ttccagtgtt 185341 tcatttttac cactgtaaga tcggcatcaa tactaaattc tttgttgaac agtgaagcca 185401 attcgcctat cgtcatccca tgcttcaatg gaatgggata caatccgaca aatgaggcgt 185461 attcaggttc taagattggt ccttcaatat gattcccgcc ttgaggattc ggacggtcca 185521 gcaccataaa tggaatgccg ttttctttag cggcttccat tgcgtatgcc attgtataaa 185581 tgtacgtgta gaaacgggtc ccgacatcct gaatgtcaaa cattagaata tcgacatttt 185641 taagcatttc tggagtcggt tttttcgttt ttccgtagag gctgtatacg ggaaccccgg 185701 ttttttcgtc aatgtaagag cctacttcgt ctccagcctg ggcgtcaccg cggacgccgt 185761 gttcagggcc gaataaagct gtcagtttga tatccgggtt ctcgtaaagg atatcgacac 185821 tgctttttag agatgtgttt actccggctg gattggtgat cagtccgatg cgttttccct 185881 tgagctgttt tttatagtct ggcaagagcg tgtctatccc agtctggact ttaggttttt 185941 tagctgtttg attctttgaa tcgggtgaag cagaggcagc ggttatcgtt ccgaacatca 186001 tgagccctgt cagaaaagcg aatattgttt ttctcatgtg tccctcctta ttaaagcggt 186061 cttcccgttt tgatatttaa tccgtagcca agtgggtaaa gggtgttccc tggtttcgtg 186121 actgacggaa tgtcaactgg aagtgtgcct ttaggttttg cctggccgaa tatcgccatc 186181 actccggccg gaatattagg ttgaagataa cggccatttg cgtatccttt aaagccatag 186241 actgcaatca gtgcttttgc ttcttcgaaa ttggctgcgt cataggggtt gcgcaggctc 186301 attaagacaa atggtttgtt gtgctgcagt gcggctttca tgacagctct cggaaacacg 186361 gtggcccatt tgcttgaatc tgatattgtg tcgtcgatga caccgtcgtt gacgacaggg 186421 tcatttttga cgacatagga gccggtaatg atataatcag cctcttttac ttgtttttca 186481 tgctcggtct taaatacttg gctggcaaag ttcattttgc tgagggatac gggtttgatt 186541 ttctttcgct tgatgagatc gtgaatggtt tgttcgattg aagcagtttg ttcttcgtaa 186601 ggtgccacaa ttaagattcg gctgcctttt ttaggcttga acggcaaagt gtgctgttca 186661 ttttttaata cagttactgc tttttcagct aattttttct ctgctttcag gtgctgcttg 186721 cttcctacga tttttttggc tttggctatt ttttcttttg tactgtcgct gtttcgcgct 186781 ggatacatgc cgcgttttat tttcagggaa atgattcttt caactgaatt gttgatttgt 186841 tgttcaggaa tatccccgtt tttcacggct tctttcaaag cttgaataac acgtgcgaat 186901 ttctgttctt ctttcaatga agtgactgag gctggcatta atgcaatatc gacaccagct 186961 tttacggcca tgaccacagc ctcttcctgt ccgaaatgat ctgcgattgc cttcatattg 187021 agcgcatcgg taacgatgac cccattaaag cccatttcct gacgaagaag acctgtcatc 187081 actttttttg aaagtgtagc tggaaccaga atgtccgatc catcgagttt gcttttgtaa 187141 gtggtgtcat caaaggcggg aaactgaaca tgggctgtca tcaccatatc agcaccagca 187201 tcaattgctt tttgaaaagg ataaagctcg acctcacgaa gccgttcttg gccatgggaa 187261 acgagcggca gtccataatg gctgtcaacg tccgtgtctc catgtcccgg gaaatgtttg 187321 agggcagacg cgatatcctg ccgctgcaac cctttcatcg tatataaacc gaggcgtgat 187381 gtcagttctc gattggagct gaatgaccgt acgccgatta caggattatc aggattattg 187441 ttaatgtcca cgacagggct gaaatctgta ttgatgccta aggcagagag ctcttttccg 187501 atgatgctgc cggtctgata cgcattgatt ctgcttctgg ctgcgcccag cgccatattc 187561 cctgggaaat tagtgccctc ccctaacctc gttacaatgc cgccttcctg atcaatactc 187621 agcatgagcg ggatttttgg acttgccttt tggtaatcgt ctgtcagttg gacagtttgt 187681 tttgttgttt ttacattttc tgcaaaaagg atgatgcctc cgaattgata tttcttgacg 187741 aggctggcga cttcatcatt catttttgta agggcttgcg gagaggactc gccttccttt 187801 tgccaatttc taaaatcagg catcagcatc tggccgagtt tttcatctaa cgacatacga 187861 ttgacaatct gattggcatc gattgcacgt ttggatgcag aggcttctgt ctgtctggcc 187921 ccgaaaaagc atgaaagaaa gagaacggct gaaaggataa gcggaaagac aggtctcata 187981 gaaacttcct cctatcgtct aatcattcac tccatcgctt cataaatcgc ggttatgaca 188041 cttccataac tgcctgttgg aaattggtca ccttcaaaga cgttcggatt ttcttccgga 188101 tcaataactg gtgtatgctt tttatttgtt aacaatgcga tgcctaaatt gtatgctgga 188161 tcaataattg taactgtccc cgtccagccg gtatgcccgt aagcattttc gctggcatga 188221 gggccaaaca tccattccat gcttttactt ccgttccgcc tccagccaag agcgaatgtc 188281 ggatctgttg ctgaaggtgc tgtaaacagg tcggctgttt tctgatcaaa taaagaaatg 188341 tttcggtatg aacctttgtt taacatgact tgcagcagta tggccatatc atctgcattt 188401 gagaacaatc cggcatgccc agacacgccg tccattgagt aaaacgcttt ttcgtcatgc 188461 acctctcctt gcagcgtgtt tgtgcggatg ttagggaatt gaataacgcc gtcacgtgta 188521 ttgcccatgc gttcagtagc tgcgaactgt ttcggtttaa agcccttttg cagcggattg 188581 tacaaggtat gcttcagcct gagcggtttg tagagctctt gctccgtgta gacatcaagc 188641 ggtttgccgg tgagtttttc gacaatacat ccgagtagca tatatccaat gtcactgtat 188701 acgtgttttg tcccggtttg ataatcgagc ggaattttcg tcaaatattc aatcgttttg 188761 tcccgttctt gggaatagta cttgccggct ttttccggcg tgtaaaagta aaagcttgat 188821 gggagccctg attggtgctg gaggacatca atgacacgta tcttgtcttt tccttttatg 188881 aggtcacccg gctgatcctt gaaacccggc aaatatgcag aaactttttc atagacgtca 188941 agttttcctt ggctgactaa gcgctgcaat gcaaaatttg ttgcgtacat ttttgtattt 189001 gaggctaagt caaacatcgt gcgggttttc attttggccg gacggcgcag cagttctgat 189061 ccttcgtact ttttactgta gccgtatgct gcttttttta tgatgcgtcc atccttcacc 189121 accacaagaa cggcgcctgg aaatcctgct gcaatatccc gttctatcat ctgatctacc 189181 ttccttagct tcttcgtcga gaattgtgca gtttctgcat ttatgatttt cggctcaatc 189241 aagttgcctg ctgtttgtgc gaaggtttca tttggcgcaa atatcgatag ggttaaaatg 189301 gcactgaata tgaacagtgt ctttgttttc acaggctagc ccctttctgt gcttctatcc 189361 cgtttactat ccctaaaaca gaaacaattt aatcgaactg agaagccatt tcatctttat 189421 atccgaatgc ataggtcaat aaaaaaccgg ccgcgtagga aataaagagc ccaacgatat 189481 acaggatgat ttgcgaaggc aggactagaa aagatagcgg cagtccggag acaccaatcg 189541 caatggtggc tacttgaaaa taagcttgaa aggcgccgcc gattccagct cctaaacatg 189601 ctgttaaaaa cggacggcca agcggcagcg tgactccgaa aataagcggt tcaccaatgc 189661 cgagcagtcc cgatggaagc ccgccggcga ttgctttcct cagtgttgtt tttttcgtct 189721 tcacgaaaac ggcaaaggcc gcgcctacct gtcctgcacc tcccatagcc aaaataggga 189781 gcagaggatc attgccaatt gaattgatca gttccatgtg cacaggcgtc aagccttgat 189841 gcagtccggt tacgacgaga ggaaggaagg ttgcgcccag aataaagccc gcagcgatgc 189901 cgccgatgtc caggatggac agtaggccgg atgtaatagc atcagaaatg aatccgccta 189961 aaggcataaa tacgacatac gttacgattc cggtgattaa cagtgaaacg gtgggtgtga 190021 caatgatatc aagtgattga ggaataaaac ggcgaataaa ttgttcggtg taagcaatga 190081 atatggctgc gaaaaggacg ccgatcagac ctcccctgcc cgggagaagc tcttctccaa 190141 ataaactgat ttttgcgatc tccggattga taatcaagat cccggccaaa gccccaagtg 190201 cgggtgtccc gccaaattct ttcgaagcgt taataccgac gagaatgccg agataagtga 190261 acagccctga tccgatgact gtcaggataa tcgcaatttg tgagtctgca gagagccagc 190321 ctgcttgaat aattgctttg gtaatcccag taattaaacc ggaagcgact agagcgggaa 190381 taagagggat aaaaatgctg gcaattttac gtaagaaaag tttaaaagga gtggcatttt 190441 tccgattgat atcggctttc tttttggccg ctgcttcttt gacatcggca ccttcttctg 190501 ctgacacgag ctttgagaaa gcagctgtaa catgattgac aactcctgtg ccgaggataa 190561 tttgtaaggt ttcagcttca acgaccccca atacgccgtc aagctttctt aaagcctgag 190621 catccgcttt gctttcatcg taaggcgtaa tgcgcaggcg tgtcatgcaa tgcgtatatg 190681 aagaaatatt ggattttcct ccgcatagct caaggatttt ctgtgcgaga tgatggtagt 190741 tattttcttt gctcattaaa acccctcccc ttcaagatgc cttattttat tctcatagat 190801 tgtatggctg ctctcgtttt atctatataa ccggttgtcg tttcatactg ctcagccgcc 190861 atgcctaaaa acaaaacatc aattataaaa agctgggcga ggcgggaaga agtggctgca 190921 cttcgaatca aggcttcatt ggaatgggct gtatacaaag ggacatcagc cagtgcggag 190981 acggatgtct gactgaattg tgtgaggctg atcgttgtga tgcctttttc cttagccatg 191041 gcgaacagtt caacgatttc ctgtgtctct cctgaaaacg aaatggcgaa tacgatgtcg 191101 tctttatctg catttgcgat taaagatgcc acaagatgag tgtctgtaaa cgcggttgct 191161 tgtttatgaa tgcgaagcca cttttgctgg gcgtccttgg cgacaatgcc ggaagccccg 191221 aggccgataa aatgcacggt atgagctttg agaagcagag aaaccgctcg ttcaagctct 191281 ttgtagtcca tcaggtctga agtatcctga atggcttgaa tggcattgcc ggccgttttt 191341 tcggaaatgg agggcagcgg ctcgtgggga acaatatccc ggtagccctg aaacgtaggc 191401 tttgccagat cgcctgctac tctcattttt aaatcttgaa atccttttaa accgagtgat 191461 ttgcagagcc tgatgacggc agcgtcactt gaattggcta aggcgctgat ttcgttgacc 191521 gtgctttcga ttgctttgtg gggatgggct aggatataat ctgcaagttt gcgctcggat 191581 ggagggagct tatgcttcat tgattggatg atcgctaaac cgcctgtggc cattctagtt 191641 ctctccttat catggatggt aatgttcgat tgctttgtca atgaaaccgt ttgcttcatc 191701 gagtaatgtc tgtgcttgtt tctgatctgt gcttgttttg agcatgacga ttgctgtttt 191761 gacgtgatga tcggcttgtt ccagagtgta tctggctgtg tcgtatgaag cgtttgtaag 191821 gctttggatg atgctgatgg cgcgttcttt tagttttttg ttgctgacgt tgacgtctac 191881 catcaagttt tcgtaaacct tgccgatttt gaccattaca gcggtagata tcatgtttag 191941 aatcatttta tgagcggttg cggctttcat acgtgttgat cctgtaatgg cctcaggtcc 192001 gacgacaacc tcaatgctgt gatccgcatc cttgctgatg gcggaatttt cattgcaagt 192061 aagggcgatg gtgtgtgctc cgactttacg ggcgtatctt agggcgcctg cggcgtaggg 192121 tgtgcggccg cttgctgcga tggcaatgac ggtgtcattt gaagtgagct gtatgtttct 192181 taaatcttca gctcctgctt cttcactgtc ttcaatgccc tctgctgcct gtaaaaaggc 192241 ttcggggcct ccagccatga ttccgatgac ctgatctggg cttacgctgt aggtgggagg 192301 acattcaaca gcatccatga cgccgagtct gccgcttgtg ccggcgcctg tatatatgag 192361 ccggcctcca ttttgaaacg attcatatgc gcagtctaca gctgttttga tgtcggggag 192421 aacctcctga acggctgcag cgactttcat atcttcgttg ttgatcattt taaggatgcc 192481 gagagtgttt gctttgtgga tttcaactgt ttgactattg cgtgattccg ttgtaagacg 192541 gtgaaggttt aatggttctg acatgaggat gccccctgtt ttaaaatgat atatctcaat 192601 attcagtata ttcatttctg ttatgatatt tcaactatgt ttttaaattt ttgaaatttt 192661 atttcactta agactataag aaatgatgaa ggatcaactg ttctccaagc ggcccgattc 192721 ttcgccgtcc tttatcaagg aacccgcttt tcatataaag gtgttttgcg cgtatgttca 192781 gatgattgac ggccaagatg atttcgtcgc accatggaaa atatccgctc acaaaagcgg 192841 gaagcaaaag catggctttt ttcgcatagc cttttccgtg atgcacagcg gttaaagaca 192901 gggagctgag cagtaaagca aatggattgt tagaatagga agcaagcgtt tcttttgatg 192961 catgtaaaat gaaaaaaccg actggaaggt cgtcttttaa gatgacaacc gggtatcggt 193021 cctgtatgcc cagagcctga gacagcacct ctttcgggag ggaggtaaag cgtttgtcat 193081 cgttggtgag cgtgaatgat tggagctcgg gcaagtgttc aggcttatag aaggataaag 193141 aaatgtcttg agtcatgggg tggcctcctt acaatatgtc gttaagctcg ttttccgaaa 193201 tgacgcggta gcccgcttgt tttaacagtg cggcggttac tccgctgccg gtgatttttt 193261 tgccagagaa tgtgccgtta tagataaaac cgcttccgca agatggactg ttttctttta 193321 atatgacggc agaagcgttg atttcttttg cgtaagccaa tgttttcgcg gcgccttcca 193381 tatatagttc tgtgacgtct tctcctgaag ctgtcacgat tttcgctgtt ccattgagga 193441 catcctcgcc agtgcctcct atgatttctg cgggttcgcg tggggtagag aagccgccga 193501 gaagttcagg gcaagccatg actgctttct tttcatcgac tagttttctg attttctccg 193561 acgctgcgtg agagccgtta tatctgcatt caatgcctcc aaggcaagaa ctgactagaa 193621 tcatattggt ttctcctctc ttgctttgct tgtctctatc ataaaataaa tggctttagt 193681 tgggaggctt tttcagttaa aaaaggagtt aaaaagtttg aaaataaaaa atttaatttt 193741 cctctttaca aacagggggt gacctgtata taataacttt tgtcagctcg acgagaacac 193801 aacggcccgt tggtcaagcg gttaagacac cgccctttca cggcggtaac acgggttcga 193861 atcccgtacg ggtcaccatt tggaggatta gctcagctgg gagagcatct gccttacaag 193921 cagagggtcg gcggttcgag cccgtcatcc tccaccatct tgccggtgta gctcaattgg 193981 tagagcaact gacttgtaat cagtaggttg ggggttcaag tcctcttgcc ggcactgttt 194041 tttcaaaatt ttatgtggag gggtagcgaa gtggctaaac gcggcggact gtaaatccgc 194101 tccctcaggg ttcggcagtt cgaatctgcc cccctccacc attattgggc tatagccaag 194161 cggtaaggca acggactttg actccgtcat gcgttggttc gaatccagct agcccagtca 194221 cagacacctt tgatcaaaag gtgtcttttt tcttttcgga aaaatcattc caacttctaa 194281 ctgttcagtc tgtataataa ttttaaaaat atgttaaggt agtttattca cgaattacca 194341 tctacaccct gccaaaaatt tgataaactt attttataaa aaaattgaaa ccttttgaaa 194401 cgaagctcgt atacatacag accggtgaag gcagaggtta gataaatatg gaaatgatga 194461 ttaaaaaaag aattaaacaa gtcaaaaaag gcgaccagga tgcatttgcg gacatcgtag 194521 atatttacaa agataaaatt tatcagcttt gctaccgtat gcttggcaat gtgcatgagg 194581 cggaggatat tgcacaggaa gctttcatca gagcgtacgt taatatcgac agttttgata 194641 ttaaccggaa attttcaact tggctttatc gaatcgcgac caatttgacc attgaccgca 194701 ttcgcaaaaa gaagccggat tattacctcg acgcagaggt ggctggtacg gaaggcttga 194761 ccatgtattc tcaaatcgtc gcagatggtg ttttgcctga agatgcagtt gtatcgctgg 194821 agctctcaaa cacgatacag cagaaaattt taaagcttcc tgacaaatac agaacagtca 194881 tcgtattaaa gtatattgac gaactctcat taattgaaat cggggagatt ctaaacattc 194941 ctgtggggac tgtgaaaacg cggattcaca gaggcagaga ggctcttaga aaacaattaa 195001 gggatcttta agtggggtga tgaaatgagc tgtcctgaac aaattgtgca gcttatgcat 195061 atgcatcttg atggagatat ccttccaaaa gatgaacacg tattaaatga acatctggag 195121 acatgcgaga aatgcagaaa gcatttttac gagatggaga aatccatagc gctcgtacgg 195181 agcacatcgc atgtcgaagc ccccgcggat tttaccgcta atgtcatggc aaaattgcct 195241 aaggagaaga aaagagcttc tgtaaaaaga tggttcagaa cccatcccgt tatcgcagct 195301 gctgcggtat tcatcatttt gatgggcggg ggttttttta acagctggca taatgaccac 195361 aatttcagcg tgtccaagca gccgaatctt gtggttcata accatactgt gaccgtgcca 195421 gaaggtgaga cggtcaaagg tgatgtcact gtcaaaaacg gcaagctgat tattaaaggc 195481 aaaatagacg gggatgtaac cgtcgtaaac ggcgaaaagt atatggcctc tgctggacaa 195541 gtcaccggtc agattgaaga aatcaatcag ttattcgact ggacatggta caagatgaag 195601 tctgcgggga aaagtgtact cgatgcattc aatccgaacg gagaagagta aagcgcgtta 195661 gccgctttgc tctttttttg cgggctgaga gggctggcac atttcacttg ctaaatcgaa 195721 atgtggtata atgggctcgc tatgtaaagt acatatgcgt aacacgtaaa acacaaaata 195781 cgaaatgact gaaatcttgg aggacgagga aatggctttt gaggatatcc cttttttgca 195841 gtacctcggc aatgccgttg atattctcct tgtttggtat gtgatatata aattgattat 195901 ggtgatacgc ggcacgaaag cggttcagct gttaaaagga attgtagtca tcgtgcttgt 195961 tcgtatggcc agccaatatt tgggcctcag cacacttcaa tggctgatgg accaagcgat 196021 aacatgggga tttttagcaa ttattattat ttttcagcct gagctgagaa gagcgcttga 196081 acagctaggc cgcggccgct ttttttcgag gagcggcacg cctgttgaag aagcgcagca 196141 gaaaacgatt gaggccatta caaaagcaat caattatatg gcgaaacgcc gtataggcgc 196201 cctgctgacc attgagcggg atactggaat gggcgattat attgagaccg gcataccact 196261 aaatgccaaa gtcagctctg agctgctgat caatattttt attccaaaca ccccgcttca 196321 tgacggtgcg gtaattatga aaaataatga aattgccgcg gccgcctgtt atctgccgct 196381 ttctgagagc ccgtttattt caaaagaact gggcacgcgg cacagagcag ctgtcggtat 196441 cagtgaagta acagacagtt tgacgattat tgtgtctgaa gagaccggcg gcgtcagtgt 196501 ggcaaagaac ggcgaccttc acagagagct tacagaagaa gcgctgaaag aaatgcttga 196561 agccgagttt aagaaaaaca ccagagacac ttcttctaac cgctggtatt ggaggggcaa 196621 gaaaaatgga taaattctta aacaaccgct gggctgtgaa aattattgct ctgcttttcg 196681 cgctcttgct ttatgtggcg gttaacagca accaagcacc gactccaaaa aaaccgggtg 196741 aatctttctt tccgacatca acaactgatg aagcaactct gactgatatt ccggttaaag 196801 cgtattatga tgatgaaaat tacgtcgtga cgggtgttcc gcaaacggtt aatgtcacga 196861 taaaaggctc gacaagcgcc gtgaaaaagg ctcggcagac caaaaacttt gaaatatatg 196921 ccgatatgga acatttgaaa accggcacac ataaggttga gcttaaggcc aaaaacgtgt 196981 cggatgggct gacaatctca attaatccgt ctgttacgac agtgaccatt caggaacgga 197041 cgaccaaaag ttttcccgta gaagtggagt actacaacaa aagcaagatg aaaaaaggct 197101 attctccgga gcagccgatt gtcagtccga aaaatgtgca gattaccgga tcgaaaaatg 197161 tgatcgataa tatttctctt gtaaaagctt cagtgaattt ggaaaacgca gatgaaacga 197221 ttgaaaagga agcgaaagtg actgtctatg ataaagacgg aaacgcgctt cctgtcgacg 197281 tggagccctc ggtcatcaag attaccgttc cggtgacaag cccgagtaaa aaagtgccct 197341 ttaaaattga acggacagga agccttcctg acggtgtcag catagcgaat attgaatcca 197401 gccccagtga ggtaacggtt tacggctcac aggatgtgtt ggattctctt gaatttattg 197461 acggcgtcag cctagattta agtaaaatta acaaggattc cgatatcgag gcagatattc 197521 cgcttcctga cggtgtcaaa aaaatctcac cgtcaaaggt gactttgcat atagaagtcg 197581 atagtgaagc ggatcagaag ttcgagaatg tccctatcaa gactgtaggg ctgagcagct 197641 cacaaaacat tgaatttctt gatcctgaat cacaagcgat agatgtaacg gctaaaggct 197701 ctcccacgaa tataaataaa ctgaaaaaat cagatattga attgtatgtg aatgtttcag 197761 atttagagga cggggagcat agcgtgaagc ttgaagtgaa cgggccacag aatgtaactt 197821 ggtccttggg gcggaaaaac gccaaaatca agctgacgtc taagaaaagc aatacatcaa 197881 cgaatgataa cagcagcaat acatcaggga accaggacac agataaacaa acaaatgatc 197941 aaaagaacaa tcagcaagaa gatacaaaga acactgataa aaacaacaac gatcaaaacc 198001 aagacggaaa taaagatcaa aaccaagatc aggatgagga tgaatccact gcgaattcac 198061 aatcctcatc ggaataaaaa aggagcgatt ataaaatggg caagtatttt ggaacagacg 198121 gtgtaagagg tgtcgccaat agtgagctta cacctgagct ggcctttaaa gtcggacgtt 198181 tcggcggtta tgtgctgaca aaagacaaac aacgtccaaa agtgctgata ggccgcgata 198241 cacgcatctc cggccatatg ctggagggag cccttgtcgc cggactttta tccattggcg 198301 cagaagtcat gcgcctgggt gtcatttcta caccaggtgt atcttatttg acaaaagcga 198361 tggatgcaga ggcgggcgtc atgatttccg cttctcataa cccagtgcag gataacggca 198421 tcaaattctt tgggggagat ggatttaagc tttctgatga acaggaggct gaaattgagc 198481 gcctgatgga cgaacctgag gataagctgc caagacctgt cggagcagac cttggacttg 198541 taaacgatta ttttgaaggc ggacaaaaat atctgcaatt cttaaaacag acagctgatg 198601 aagatttcac aggcattcat gtggcattgg actgtgccaa tggcgcaacg tcatccttgg 198661 cgacacacct gtttgctgat ttagatgcag atgtttctac aatggggact tccccgaacg 198721 gattaaacat taatgacggc gtcggttcga ctcatcccga agcgctcagc gcgtttgtca 198781 aagagaaaaa cgcggatctc ggtcttgcgt tcgacggtga cggcgaccgc ctgattgctg 198841 tcgatgaaaa aggaaatatt gtagacggcg accaaatcat gtacatatgc tcaaaacatc 198901 tgaaatcaga gggccgttta aaggatgata cagtggtttc aaccgtgatg agcaacctcg 198961 gcttctataa ggcgctcgaa aaagaaggca tcaaaagcgt gcagacagct gtcggcgacc 199021 gctacgtagt agaagcaatg aaaaaagacg gctacaacgt cggcggagag cagtcaggac 199081 atcttatttt ccttgattac aacacgacag gggacggatt attgtctgct attatgctga 199141 tgaacacttt aaaagcaaca ggcaagccgc tgtcagagct tgcagctgaa atgcagaagt 199201 tcccgcagct gttagtcaat gtgagagtga ctgataaata taaagttgaa gaaaatgaaa 199261 aagtaaaagc agttatttct gaagttgaaa aagaaatgaa cggcgacggc cggattttgg 199321 tgcgcccttc aggaactgaa ccgctcgtcc gtgtcatggc tgaagcgaag acgaaagagc 199381 tgtgcgatga gtatgtcaat cgcattgttg aagtcgtccg gtcagaaatg ggattagagt 199441 aacgaagtct attatcagag agtgaacaag acaagcgagg tttacataag ataattgtga 199501 gacatacggc aaagttgctt aaaaaacaat tgaccgttta tgccacatgt tgtaaaatca 199561 agcttgtctt gttcttattt tctcaatagg aaaagaagac gggattattg ctttacctat 199621 aattatagcg cccgaactaa gcgcccggaa aaaggcttag ttgacgagga tggaggttat 199681 cgaattttcg gcggatgcct cccggctgag tgtgcagatc acagccgtaa ggatttcttc 199741 aaaccaaggg ggtgactcct tgaacaaaga gaaatcacat gatcttccaa aaaacatgta 199801 ggaggggacg attgaaagtc cccttgaaat ttgactttct tcgtctcctt ttacaatctt 199861 aggaggaaga aaaatatgtg tggaatcgta ggttatatcg gtcagcttga tgcgaaggaa 199921 attttattaa aagggttaga gaagcttgag tatcgcggtt atgactctgc tggtattgct 199981 gttgccaacg aacagggaat ccatgtgttc aaagaaaaag gacgcattgc agatcttcgt 200041 gaagttgtgg atgccaatgt agaagcgaaa gccggaattg ggcatactcg ctgggcgaca 200101 cacggcgaac caagctatct gaacgctcac ccgcatcaaa gcgcactggg ccgctttaca 200161 cttgttcaca acggcgtgat cgagaactat gttcagctga agcaagagta tttgcaagat 200221 gtagagctca aaagtgacac cgatacagaa gtagtcgttc aagtaatcga gcaattcgtc 200281 aatggaggac ttgagacaga agaagcgttc cgcaaaacac ttacactgtt aaaaggctct 200341 tatgcaattg ctttattcga taacgacaac agagaaacga tttttgtagc gaaaaacaaa 200401 agccctctat tagtaggtct tggagataca ttcaacgtcg tagcatctga tgcgatggcg 200461 atgcttcaag taaccaacga atacgtagag ctgatggata aagaaatggt tatcgtcact 200521 gatgaccaag ttgtcatcaa aaaccttgat ggtgacgtga ttacacgtgc gtcttatatt 200581 gctgagcttg atgccagtga tatcgaaaaa ggcacgtacc ctcactacat gttgaaagaa 200641 acggatgagc agcctgttgt tatgcgcaaa atcatccaaa cgtatcaaga tgaaaacggc 200701 aagctgtctg tgcctggcga tatcgctgcc gctgtagcgg aagcggaccg catctatatc 200761 attggctgcg gaacaagcta ccatgcagga cttgtcggta aacaatatat tgaaatgtgg 200821 gcaaacgtgc cggttgaagt gcatgtagcg agtgaattct cctacaacat gccgcttctg 200881 tctaagaaac cgctcttcat tttcctttct caaagcggag aaacagcaga cagccgcgcg 200941 gtactcgttc aagtcaaagc gctcggacac aaagccctga caatcacaaa cgtacctgga 201001 tcaacgcttt ctcgtgaagc tgactataca ttgctgcttc atgcaggccc tgagatcgct 201061 gttgcgtcaa cgaaagcata cactgcacaa atcgcagttc tggcggttct tgcttctgtg 201121 gctgctgaca aaaatggcat caatatcgga tttgacctcg tcaaagaact cggtatcgct 201181 gcaaacgcaa tggaagctct atgcgaccag aaagacgaaa tggaaatgat cgctcgtgaa 201241 tacctgactg tatccagaaa tgctttcttc atcggacgcg gccttgacta cttcgtatgt 201301 gtcgaaggcg cactgaagct gaaagagatt tcttacatcc aggcagaagg ttttgccggc 201361 ggtgagctaa agcacggaac gattgccttg atcgaacaag gaacaccagt attcgcactg 201421 gcaactcaag agcatgtaaa cctaagcatc cgcggaaacg tcaaagaagt tgctgctcgc 201481 ggagcaaaca catgcatcat ctcactgaaa ggcctagacg atgcggatga cagattcgta 201541 ttgccggaag taaacccagc gcttgctccg ttggtatctg ttgttccatt gcagctgatc 201601 gcttactatg ctgcactgca tcgcggctgt gatgtggata aacctcgtaa ccttgcgaag 201661 agtgttactg tggagtaata attaattaac ccctttggat aagaaggtct tcacatgtgc 201721 tgctaggctc caaatgtaca cctttccgta agggcaaagt caaatgtgaa aaaaaactgt 201781 tccaaagtta atcagaaatt tattttcata ttgtatcctt cggtatcaag tgaaaggagc 201841 atcatatgaa aacattatgg aaagtcctca aaattgtttt tgtcagcttg gctgctttgg 201901 ttttgcttgt atccgtctcg gtatttattt atcaccattt ccagctaaat aaggaggcgg 201961 cactgctgaa aggtaaaggc acagtagtcg atgttgacgg taaaaagatg aatgtgtatc 202021 aagagggaag cgggaaggat acgtttgtgt ttatgtccgg ttcgggtatt gctgcgcctg 202081 cttatgaaat gaaggggctg tacagcaagt tttcaaaaga aaataagatt gctgttgtag 202141 atcgggcagg ttatggatac agtgaagtgt ctcacgatga cagagatatt gatacggtat 202201 tggaacagac gaggaaagcg cttatgaaaa gcggaaataa gcctccttat attttaatgc 202261 ctcattcgat atccgggatt gaagcgatgt attgggcaca gaaatatcct aaggaaatca 202321 aggccattat tgcgatggat attggattgc cccagcagta cgtcacgtat aaattgagcg 202381 gagttgaccg attgaaagtg agagggttcc acctgttaac ctcgattggt tttcatcggt 202441 ttataccttc cgctgtatat aatcctgagg tgattcgaca gtcgttttta actgatgaag 202501 aaaaagaaat ctataaagcc attaacttta agcaattttt taatgcagat atggagcatg 202561 agcttttaca gtcttaccaa aacggcagca aatctgtgaa tctgcctgcg ccaaaggaaa 202621 ctcccgtctt gattttagat gcagtctctg accaaaatag acattcaaag tatgctatac 202681 aaaaccgaaa agactatgaa gcgtttgcgg ctcaattcaa tactgccgat ataaaggaac 202741 tgaggggaac acacagtatt tatttatatc agcctgatca aatatataaa ctgtccatgg 202801 agtttatgag aaaggttcgc taggatgaag ggttatcgta ttttaatcgt tgaggacgat 202861 gtgatgattg gtgatttgct gcaaaagatt ttgcagcgcg agggatatcg tgtgatatgg 202921 aaaacagatg gagcggatgt gctttcggtg attcagaagg tggatttggt cattatggat 202981 gtgatgctgc cgggtgaaga cgggtatcaa atgtctgcaa aaatcaaaaa gctggggctg 203041 ggcattccgg ttatttttct ctcagcccgc aatgacatgg acagcaagct tcaaggtttg 203101 cagatcggcg aggattatat ggtaaagccc tttgatccga gagagctgct attaagaatg 203161 cggaatatgc ttgagcatca ttatgggacc tttacgcaaa tcaaacattt gtatattgat 203221 gcggtaacga aaaaagtgtt caatgaaagc ctgcatgatg aggtattatt tactgcgatt 203281 gagcggaaaa ttttctttta tttatatgaa aatagagaca gtatcctgac aaaggaacat 203341 ttctttgaat atctatggca gctcgaagat agaaacccga atattgtcaa tgtgcatatt 203401 aaaaaaatta gagctaaaat caatgatcaa gcgggtgaga tgattgaaaa tatatatgga 203461 gaagggtatc ggctgaatac cgttgtgaag aaatgaagct caagacaaaa tatcagttgt 203521 tattgtttac ggccgtcatt agtgttccga tgctattgct ggcggtcagt gttttgatgt 203581 cggtgattta tgacagcatg tttaaaccga tgaatcatgg tatgcccttt cacaggtcgt 203641 ttgcataccc ggcaatgatc gttgtatttt tgatatcact cttattgtta gcttttttat 203701 tttcaaagtc gattcattct ctgttgcata aaatcaatct attaaatcaa accattcggc 203761 atttggcgag tgatcaaagg gtgcccgata aaattgaagt gaagcgtgct gatgaaatcg 203821 gggaactgat caagtcggtc aatttgttaa ttgaacggac gacatatcgt gaactggagc 203881 tgagacagca ggaggaaatc aaaaaggagc ttttgcaaaa actgcggcat gacattaata 203941 cacctttaac ggctctcagg ctgcagttat tttatttgga agaccaatgt catggtcagg 204001 ctgtattcga atcattgtat cagcaaatcg aatatatctc ggaattaact aatgaattca 204061 atctatattc cgctgagacg ctggaaagct cttatattgt aaatgaagaa gtgcgtctaa 204121 acgagctatt agaaacagcg gtgaaaaagt gggattattt atacagtatg agtgggattg 204181 agctgcacta taagccggca gatcaagatg tgatatggat gagcaacacg ttatggatgg 204241 aaaggctgtt tgataatatt tttcaaaata cgttaaggca ttcaaaagct aaaaagatgg 204301 aagtcacgat tgaacatggc gatgttttta ttcgtgatga cggtattgga tttgatcgga 204361 atgagagcag tgagggactt gggttaaaga ttattgagga tacatgcagg ctgcttgcga 204421 ttacttatga gctgcataca aatgataacg gaacggggtt cttgttttca aaagagtgac 204481 cccgctgatg tttttctttc tcctataaaa tttatataat agggagaaag aaatggggtg 204541 aacatcatat gtttaaaaaa atcatcaaaa cgattaagta cctctcaagc agttctagtg 204601 accgatatcg cagacaccgg cattacagca gcagccggcg cagacattat cgcagctaca 204661 gcagcagttc gggcaaaaga agacactacg accgttatgg cggcagtcat cgttacaaac 204721 gccggagcta cagcagcagt taatccaaaa aaagttcttg ttccgctttt gggacaaggg 204781 tttttttatg tgaccgattg aatggcccgg tttagatcct cgcgaatgga agcggtgtgc 204841 tgatactctt cctcaatgcc caataatctt ttcagcagca aggttacttc ctttgtcagt 204901 gttaattcct ccagccaagt gccgtttttc ttcttttttc ctttatattg agagtacagc 204961 aagaataaca gcgtttctcc gagatcgaag aagtcatcct gttttcgtac ctttatttcc 205021 tccatttctt caggagtcaa ttgtttggca aggccgaaat cgatgaggca gagcctgcca 205081 tcattgatga tgatattagg cgttctgatg tcgctgtgga agataaggcg atcatgcagg 205141 tattctataa tctcaagcag ctgcgaaatc agttgtaacg ccataagctc tgtgaacggc 205201 tgttttcgaa aaaataataa ttcttctata ttctctccct caatgaactg catgacataa 205261 taagcctgtc cgtctatgat gaattcatct atgaagcccg gaatttgcgg gtggtgaatg 205321 tttttgagca gttttatttc ctgctggaat cggactttct ctttttcctt tttggctttt 205381 gtcggccgaa gctgttttaa gacataaggt gtttgagcta ggatatcggt gcacaaataa 205441 accaaaccgt agcctcccat accgaggcac tcttcgattt tgtattgatg atttaagata 205501 acgccgttct ttagagggcg gtcaaatagc agttttttta gaagttttaa tgccatgtct 205561 gcacttccct tggttgtact gactatagtt taccttctag acggagaata aaaaagagcc 205621 ggataaccgg ctcggtataa gttaaaactg ctttgtcacg tcgtattcat aatctatttt 205681 tgcttttacg ttgctcatcg tcgatctggc tgtcgctaat gtattatatt taaaactcca 205741 tacctttgcc acactgagtt gatccgacaa agagatatca taagaccctg aagtcgagct 205801 gtttacaagg gcacggctcc attcgttatt ttcgcttgtc atgatcagat ggcgtgtatt 205861 tccctggctt ggtgtttgag tggcggttgt ttgaactctg gttacaatgg catcacgcgg 205921 tatcccagat tggtttgtta aatcaacctt gatcacgctg gagtcagaac ctgaggggct 205981 aaggcttgta tttcctttat tttcagcaac gccgctgaat tggaacgttc cgctgcctga 206041 tttgattcgg tcttcaattg aaagcgtaaa gtacatgttt ccagtatagg tgcctcgtga 206101 cactttcaca tagaaggtat ccgtcgtgtt ttgggcgtct gcatttgcat aaataaaaga 206161 agaaaacgta ttagggttaa taacttctgt cccttgagaa acaggtattc tgttcttgtc 206221 ataaatttca attttcatcc ctgtatacgc gctctggtat gtactcctca tgtatacttt 206281 ttctccctta ttagccgtaa aagtgaaata ggcttcatct tgaccagctt ccagtattgt 206341 tgtatcgata tttttatatt tccaataacc gatcggcatt gcggtatcaa atgaattgtt 206401 tcctgtgata gcagtgactc cgacagctga tgccgaatac gtaaaggtag ataagacaga 206461 aagcataaca gcgaattgaa taagccattt tttcaccatg caaacaacct ccttttattt 206521 ccatcataca taataacgat ttaggtgtaa ataaatgttt tttgaggtta atatatacat 206581 tatattcgcc gataaaaaag aataagagag aatactcggg agggaattca atgcgtctga 206641 atcggcaatt tatccgcact cagctgattg cacagaacat attgagcaag aatgcgcctg 206701 ccaaacggga gaatgcgact gaaaatccag cggcagttct ggaaaaggca tatagcaggc 206761 ttaagtcaca atcttcaact gggggaatca atcagttcaa ttattctaaa accagcgtgt 206821 cgggaaacag cgggacgttc agcaaagtgt atcaatcagc gaatgatcga acagtgacag 206881 acacagggga agaaacagtg attcaatccc aaaaccccta tgaatctgag agtgatatca 206941 gaatcaaaat actagatgaa aaatacagca ggatgaatgc gattaataaa acaaagtctg 207001 atccattagg ctatattaag gataagtacc aaaattcaaa gtctccttat ttcagaagtg 207061 atctgtcagc tgcagaaaga caggccgctt acgataatga aacagaatgg ttattcaaag 207121 ggaaggcgca aaactataac cttcaggatg ctgtgtttcg gaatgtcaca tttcatgggg 207181 aagtggaagc tgagaatgaa aaggtgtatc agcggggaca ggttaaccag cagctgcaag 207241 tactgttgaa tcgaaaccat attcatattc cagaggggac agagctgacg tttacaatca 207301 caccgattga ctatcaggtg cgggtaagcg ggacagacga tcaggatctg atcaagcaaa 207361 ttgagcaagt gctgcaatct ggagacaaca gcaaagaact atttttacac atcatgaaaa 207421 gtcaaagcag tgattcagca caattttccg aagaggccta taaaaagtat caggcagctc 207481 gtgagatgta tgaagttaca ggctaccatt tgaaggattt agaagtgatt gatgggcggt 207541 acgtcacgcc tgagggacgt gacttaatgg atgtatataa ggaagagctt gaaaaagatc 207601 cagtgcagaa acaaacggct tcttatgcta tatcttacta tcgttcagag ctcagtaaaa 207661 tcgcggaagc cgggtataat gccattccgg atttcatcct atcaattgat tacagcaatg 207721 gatctctgag agatgtggga caaagcaaga gctatgggac cggagatacc gggtggcttg 207781 aagcattaaa gcgtcaaacg ggtgtgaatt attaggtaag ctgttcatgt aggacagctt 207841 attttttatg agaatctaag gggtgaatta atcccaatat tcaaataatt ttattatttt 207901 tatataaaag attttaaaag aagtgaacga ttcaaaactc tgaacaaagg tgtttacctg 207961 aaaaaaacaa ttgtattttc cagagaaatt tattatgatg aaataagtaa tttaggagat 208021 tatataacaa ttttaagttt gaattttctg attgttatca ctgattcatg tgaaggcaag 208081 caggtctgct gttttctcat ttatgagtat tttgttagga ggaggaagag gagtggcaaa 208141 taaagaatta aagaggggcc tgggcgcgcg ccatattcag atgatcgcct tgggcggtac 208201 aatcggtgtt ggcttgttta tgggttctgc cagcacgatt tcatggactg gcccatctgt 208261 ccttctggct tatgcaatat gcggaatttt tatctttttt attatgcgtg cgatgggtga 208321 aatgctgtat gtcgagccga gcacaggttc ttttgcgacg ttcggccatc aatatattca 208381 tccgatggca ggttatataa cagcatggag caactggttc cagtggatta tcgtcggcat 208441 gtcagaaatt atcgctgtcg gttcttatac gaagtattgg ttcccggatt tgcctgcttg 208501 gatacctggt atcgtggcaa tggtgattct tggtgcggcg aatttaattt ctgttaagtc 208561 gtttggggaa tttgagtttt ggtttgcgat gattaaaatc gtgacgatta tcttgatgat 208621 tattgcggga atcggaatta ttttcttcgg ttttggcaat ggcggagatg cgatcggttt 208681 gtcgaacctg tggtctcacg ggggcttctt tgcaggaggt ttctcaggtt tcttctttgc 208741 actgtctctt gtcattgcag cctatcaagg agttgagctg atcgggatta cagcgggtga 208801 agcgaaggac ccgcaaaaca cgctaagaaa tgcgattcaa agtattatct ggcgtatttt 208861 gattttctac attggcgcta tttttgtgat cgtgacggtg tatccttggg atgagctcaa 208921 ctcactcgga agtccgtttg tgtctacgtt ctcgaaaatt ggaattacgg cagcggccgg 208981 cattattaac tttgtcgtga ttactgcggc aatgtccggc tgtaacagcg gtattttcag 209041 cgcgggccgc atgctgtata cactgggtgt caatggacaa gcaccgaaat tctttaagaa 209101 gatttcacgc aatggtgtgc cgctgtatgg cacaattgcg gtgctgatcg gtttggctgt 209161 cggcgttgta ctgaactata tcgcgccgcc gaagatcttt gtctatgtat acagcgcaag 209221 cgtgctccca gggatgattc cttggtttat cattttgatc agccatatcg gattcagaaa 209281 agcgaagggt gctgcattag ataaacatcc attcaaaatg ccgtttgctc cttttacaaa 209341 ctatttgacg attgctttct tgctgatggt tctggttggc atgtggttta acgatgatac 209401 tcgtatctcc ctgattgtag gcgtgatttt cttagcgctt gtggtcatta gttattatgt 209461 gtttgggatt ggcaaacgca cgcaggccaa tttgacaaaa agcgaacaag cagctgaata 209521 acgataaaaa agagacattc acggatgtct ctttttttat ttttcgcgta tggattttcc 209581 ctattttagc aagctatagg gtaaagatag cagaaggaaa ggtgttcata aaatggatgt 209641 tacactcggt tatttgcgcg aatcactttc gaatcatcta gaaaatgaag tctgccagcg 209701 tatttgcaag aagatgctgg cgaagcgtta tgcaaatgaa gaggaatttg taaaagactt 209761 agatgataat gaaatgtctt ttttgaacca tgtattagaa aaagaaatta agtatgccca 209821 gaatgaacag gatcaaaaac gggccaagga attaaacgag gtgtatgaat tactgctttg 209881 agaaaggcgg gtaagaaatg ggagcaattg aacgaagcgg atatacattt cagccggagt 209941 ttagcgttgt ccgtcaaaac ggagccatcc atgtgtacca tcaaggagaa tttgtggaag 210001 aaatcgaatt tgaatttaac ggggaatatc ccgatcatga tttgattgaa gagcttgtga 210061 atcattattg ttttgagcat gagatttaga gccctgccgt gcagggctct tttatttagg 210121 atgtaatcag gccatacttt ttcaggatat ccacggtgat gtttttggct tttgtgccgg 210181 aatcatcgac attggtgaca aagacataag agccatgctc tgttttgatg aatccgacaa 210241 accatcctaa tcccatatca gtcaggcggg ttccggtttt cccgtagagc gtgtaatgat 210301 cgccttcctc ttgaatcatc atgcgcttga cgattttcat caccggcttg tcaaatggaa 210361 gctcctcttt agccagtttc tccaaaaaag tttcttgttc cagcggagat attgtgagcg 210421 agctttgcag ccaaaactgg tcgattcccc cgctgatatc ctcgttgccg taagatagag 210481 tatgaagcca tgttttcatt ctttcctcgc cgatatctct cgctaatgcc tgataatacc 210541 agattgcgga ttcgcgcatg gccgagccaa gcgtatggtc gcggttccat gattcgaatt 210601 cacgcttgac cccgtcccat cgtttaacat cgtattcatc tcttacagct ttgacctgca 210661 aaccgattaa agcgttcacg actttaaagg tggattgcgg agtttgtctt tgatttgccc 210721 gttttctgtt atagacaaat gtctgatcct tttgtaaatc gtgaagaatg aaggttccat 210781 ccgtatcctt gaattcatca tcgacattca ttttgctgac attcaagtgt ttttcatgag 210841 cagatgatgc tgcgtggacg gagaagccgc cgatccctgc aatactcagc acaagcacaa 210901 catatatcca ttttttcatt ttgttctccc cttcgttttg attaactacc ttttctctct 210961 ttcgtttgtt cttcctttaa aaaataatca aaaagcgctt aaatttggtt ttgcaaacaa 211021 atactgttac tgggtttata gtcggaagat aacgtgaaaa tagagggtaa aaaggaaggc 211081 agggtaagcg gatgaatgag cagattccac atgacaaaag tctcgataac agtctgacac 211141 tgctgaagga agggtattta tttattaaaa acagaacaga gcgctacaat tcagatctgt 211201 ttcaggcccg tttgttggga aaaaacttta tttgcatgac tggcgctgag gcggcgaagg 211261 tgttttatga tacggatcga ttccagcggc agaacgcttt gcctaagcgg gtgcagaaat 211321 cgctgtttgg tgttaatgcg attcagggaa tggatggcag cgcgcatatc catcggaaga 211381 tgctttttct gtcattgatg acaccgccgc atcaaaaacg tttggctgag ttgatgacag 211441 aggagtggaa agcagcagtc acaagatggg agaaggcaga tgaggttgtg ttatttgaag 211501 aagcaaaaga aatcctgtgc cgggtagcgt gctattgggc aggtgttccg ttgaaggaaa 211561 cggaagtcaa agagagagcg gatgacttca ttgacatggt cgacgcgttc ggtgctgtgg 211621 gaccgcggca ttggaaagga agaagagcaa ggccgcgtgc ggaagagtgg attgaagtca 211681 tgattgaaga tgctcgtgcc ggcttgctga aaacgacttc cggaacagcg ctgcatgaaa 211741 tggcttttca cacacaagaa gatggaagcc agctggattc ccgcatggca gccattgagc 211801 tgattaatgt actgcggcct attgtcgcca tttcttactt tctggtgttt tcagctttgg 211861 cgcttcatga gcatccgaag tataaggaat ggctgcggtc tggaaacagc cgggaaagag 211921 aaatgtttgt gcaggaggtc cgcagatatt atccgttcgg cccgttttta ggggcgcttg 211981 tcaaaaaaga ttttgtatgg aataactgtg agtttaagaa gggcacatcg gtgctgcttg 212041 atttatatgg aacgaaccac gaccctcgtc tatgggatca tcccgatgaa ttccggccgg 212101 aacgatttgc ggagcgggaa gaaaatctgt ttgatatgat tcctcaaggc ggggggcacg 212161 ccgagaaagg ccaccgctgt ccaggggaag gcattacaat tgaagtcatg aaagcgagcc 212221 tggatttcct cgtccatcag attgaatacg atgttccgga acaatcactg cattacagtc 212281 tcgccagaat gccatcattg cctgaaagcg gcttcgtaat gagcggaatc agacgaaaaa 212341 gttaaattaa aaagctctct tcctttatcg aagagagctt tttgattact tctttttttc 212401 atcgtagtat tggacgggat acatggagcc ttctgatacc attttgttgt cctcgatatc 212461 ttgcgggtcc gggtggccgg ctttatcaac tgggaacgtt tccatgtctg gctgttttgt 212521 tattttcatc ttcatgctgt gaatgaattc tcttgccttt tggcgatttg acgggtcttt 212581 taatagataa gaagtgatgc cgacagttga aacagcgaga cctgaaagta acagcttttg 212641 tttcatggtg atactccttt ctattttaag aatagtgttt cctgtatcat tcccgttttg 212701 gaaattgcta aacctgttgt gtttttatca ttggaattaa cagtaaattc catttaagaa 212761 gaaactagtg acttcattcc tgtattggaa ggtaatatac attgacttat tatagatttc 212821 agtcaaaatt cgataaatat tgacaaagta aagtaatcag aataataata taattagcaa 212881 gagaatgtca tcatacatga aaggtgttta cgatatgaat caattgcatc gaagaatggg 212941 aacgttttcc ctcatgatgg tcgggctcgg gtcgatgatc ggttcaggct ggctgttcgg 213001 ggcttggcgt gcggctcaaa tagcaggacc agctgctatt atttcatggg ttattggaat 213061 ggtcgtcatt ttatttattg ctctttctta tagtgaacta ggttctatgt tccctgaagc 213121 ggggggaatg gtcaaataca cgcaatattc acacggttcg tttatcggtt ttattgcggg 213181 ctgggccaac tggattgcga ttgtgtccgt cattccggtt gaagcggtgg cctccgttca 213241 atatatgagt tcttggcctt gggaatgggc gaaatggaca agcggtttgg tgaagaatgg 213301 aacgctgact ggggaaggac tagcgtttgc ctctgtattg cttctcattt attttctgct 213361 gaactactgg acagtcaatc tattttcgaa agcgaattca ttaattacga tttttaaaat 213421 tattattccg ggtcttacga ttggagcttt gctgtttgtc ggattccacg gagaaaactt 213481 tactggcggt caaagcattg cgccgaatgg ctgggcaagt gtgctgacgg cggttgccac 213541 ttccggtatc gtttttgcgt ttaatggttt ccaaagcccg attaatatgg cgggtgaagc 213601 aaaaaatccg gggaaatcaa tcccgattgc ggttgttggc tctctttttg ttgcgacagt 213661 gatttatgtc ctgctgcaga tcgccttcat tggagctgtg aatccttctg atattgctca 213721 cggctggagc catctgaatt ttaattctcc ttttgctgat ctggcgattg cgctgaatat 213781 taactggctt gttattgtgt tatatgcaga tgcatttgta tcaccgtctg gaacggggat 213841 tacgtatacg gcgacaacgt cccgaatgat ttacggaatg gaaaaaaaca aatacatgcc 213901 gagtatattc gggaagcttc atccgattta cggcgttccg cgacaagcaa tgttctttaa 213961 cttgattgtt tcgttcatct ttttgttcct gttcagagga tggggcgtat tagcggaaat 214021 tatttctgtt gctacgttaa tttcttatat caccggcccg atcacagtga tgacattgag 214081 acggacgggg aaagacctgt acaggcctct tcgtttaaaa ggcttaaatg tgattgctcc 214141 gcttggattt atctttgcgt cactggtgct gtattgggcg cgctggccgt taacaggaca 214201 ggttctgttt attatcctga tcggtcttcc gatttatttc tattatcagg cgaaggcgaa 214261 atggaaaggg tttggccgga actttaaagc cggcgtctgg atggtgtttt atctgctggc 214321 catgatggtt atttcttatt tgggcagtga taaattcggc ggcctgaatg tcattcatta 214381 tggctgggat atggttctga ttgcgatggt atcccttgta ttctatgtgt gggcgctgaa 214441 gagcggctac cagacagaat acttaaagga tgcgaaagag ataaattctc agctgcttaa 214501 tggacagtca gaagctgctg ccggaaaaga ataaaatata gaagaaaacc ttgcgatagt 214561 tgtcgcaagg ttttttgctt ttaataaccc ttttttactt tgtggaaaag atcaggatag 214621 ttggtgaaca ctcctgttac gccccaatca agcaggcgat gcatatcagc ttcattattg 214681 actgtgtaag gatgaagcag gaggccgtgg ctgcggatca tacggacgtt ttcttgattt 214741 aaagctttat aatccgggcc cgcaccgaca gcgtatgttt tgatttcttc cagggcagca 214801 tctgtcattg acgccatttg tttggcttcc agcaattgaa cggtcggcag gtttggctgt 214861 aattgatgga cttttaccag gctttctttg ctgaacgatt gaatgatcac ctggcctggc 214921 ttagaatgct ttcccagtaa tttatgtttc tgcaaagaag cgatcagttt ttcttccata 214981 cctgggtagg tgtcaggcga ttttgtttca atgtagtagt tcgcgtgctt tccgaaacgg 215041 tctaatacct cttctaatgt aggaacttta aggccgacgt actgcggctt tgctttttcc 215101 ggataggctt cattaaacca agaaccggcg tcaagcttct taatgtctgc gagcgtatgg 215161 tctttcaccc aacccattcc gtttgtggtg cggtccagtt tttcgtcatg catgacaatc 215221 aattttccgt cttttgtcat ttgcagatcc aattcaataa aatcagcttt cattttctga 215281 gcggtttcgt aagacagaat cgtgtgctca ggcacatatc cagaagcccc tctgtgcgcg 215341 acggtcagga tacggtcagg tgacagcagg tttccttttg acgctgccga cactggcgtt 215401 accataaatg agagtaagcc cagcgacaga acaaacaagg ccagtattct attttttctc 215461 atgatttctc ctccttatag ataagcacta cctgtctttc ataataaaaa acggatgtaa 215521 acggcgtgtt ggaaaactat taatctttta tgtgtctttc ttaaacatgc tctgcccgtt 215581 ttcctgtatt ccacgtcaaa gccaagaaga cgatggcaag aatgcaggat gagatcagca 215641 tgataaagcc gccgttccag ttaaaacggt ccacgacaaa gcccataatg gcgtttgcga 215701 aggcggatcc gccgatgtat ccgaaaaatc cggtcaaacc ggctgcagtt ccggctgctt 215761 ttttcggtgc taggtcaatt gcttgaaggc cgatcagcat aacaggtccg tagattaaga 215821 agccaatgct gatcagggcg atattgtcca cgagcggatt gccggccgga ttcagccagt 215881 acaccaatac ggcaatgaaa acacccgcca taaacaaaac gcctgccggt gcccggcggc 215941 ttttgaagaa tcggtcactg atccagccgc acaagatcgt tcccggtatg cctgcgtatt 216001 cgtaaagaaa atacgaccag cgtgagtctt caggagaaaa gcctttggct tctgttaagt 216061 aagtaggcgc ccagtcaacc acgccgtatc gcacgaaata aacaaataca ttggcaaaag 216121 cgatgtacca aagaaatttg ttgttcagca catattgaaa aagaatttct tttgttgtta 216181 attctttttc ctgattttta aaagcgtgtt ttggatagtc attccgatac tcttcaattg 216241 gcgggagtcc gcaggattga ggcgtatcac gaaccaataa aacaattaaa aatgaaatga 216301 taatggcgat gatggcaggg aagaaaaaca cgcttttcca agtgacgaac atcgcgatcc 216361 caagagtgac aagcggagca agaataccgc cgcctatgtt atgggcgaca ttccagatcg 216421 acatttttgt gccgcgttca cttatggaga accaatgggc catcgtcctg ccgcatggcg 216481 gccagcccat tccttgaaac catccgttga taaacataaa aataaacatg atggtgacgc 216541 tcgaagtcac ccaaggcatt gaaacgaata gaatattaac gattgctgat aaaaataggc 216601 ctgtcgccag aaaatatctc ggattacagc ggtcagacac cattcccatg atgaatttgc 216661 tgaagccgta cgcaatggac acagcggcca gcaccaaacc cagttctgtt ttcgaaaatc 216721 cctgttcctg cagataagga atggcaaagg caaagttttt ccgcagcagg tagtagcctg 216781 cgtagccaat gaaaatacca atgaatactt gcagtctgag ccgtttgtat gccgcatcca 216841 tctttgaatc atccagtctc tcaatatgag gagccggttt aaatatatta agcattaata 216901 attatccccc tttgctgttt gtgctggatg tgtggcgtgc ctcctttccc gaaaaacaaa 216961 aagagccaga aaacacccct tgtcaaaagg ggttggattc ctggctctcc tcatctccat 217021 ccaagctatt aacttatcat gatagcgctt tcttaaatta tcatagtccg gagcgaatgt 217081 aaacgggtaa ttttcaaatt gggccttagg gaagtgaata ttatcctttt actaaatgca 217141 attatatttt tttactagta acataaaaat ctggagggag gctgtttaaa gatggatgaa 217201 ttagatatcg cattctttat tttaccgtta ggaattatgc tgctatcgat tgtcgggacc 217261 tgtatttgta aaaacccgta tctgatgcca atgcttagtt tggtgatttc tcttgtgctc 217321 acctttacca tttttaatca atcatttttg ggatgggctg ttgtctatag cttggtttct 217381 ctggctttat cctatatcac attgattgtg gtaaggaaaa ggaaggaatc aggaaattaa 217441 aaagacctca ctttctaaca tatcgttgac taaagcaact atatgtgatt ataattgctt 217501 tagtcaacga tattagaaag tgggaattga tttgaaaaca agagaatcat ctgtcgggtt 217561 aaaattcaga aagttcaatc gattttatac aaacgtcctt ggtttcctta atgagcacat 217621 ttacgacagc ccgttttcct taacagaaac acggatttta tttgagattt ataatacgcc 217681 taattgtacg gcaaaagctc ttcaggataa gctggggctt gaccggggat atgtcagcag 217741 gattgtgaag cagtttgaaa aagaagattt gatttataaa cagaggagca aagatgacgc 217801 ccgccaccat tacatttttg tcacagaaac aggaaaaacg atttataaaa agctggagga 217861 gaaagccaac gaacaagtag aactgatgct gaaggtaatc aaccaaaagg agcagcacaa 217921 gcttgccgag gcgatggcag agattgaagc gatcctttca cagtcgcttt ctgccagagc 217981 atcagagata tcgattagag attattttct ttcggaggat cttcaactcc ttattgagaa 218041 acaaagacaa ttttacgcgg aggctcacgg ttgggatgac acgtttttag cttatcttca 218101 ggagacattt gacgctgaca tcgaaaaaat atggattgcg gaaagcggcg ggaaatttgc 218161 cggctctgtc gggttggtca agcacgatga aaagacagtc cagctcagat ggtttctggt 218221 tgatgcggat tttcggggca gggggcttgg cacgcaattg ctggagcatc tggttgcata 218281 ctgccaagac atgaagtttg accgcatttt cctttggacg gtgagcacga tggctgaggc 218341 tcgtccgctc tataaaaaat ttggattcag gataagtgaa gtaaaacaag aagcgccatt 218401 atggggacag cagctgacag aagaacggtg ggatttggag ctgtcatgaa aagactgcat 218461 tatgcgtgga tcatcgtctc cgtcaccttt ttgatcttat tggcggttca gggggtgcgg 218521 ctgtcgtttg gtgcgtttgt ggagccgtgg gaacggcagt tttcaatcga tagaagcacc 218581 atctcgctga tttcgacggt gagttttatt gtttatggca tatcacagcc tgtgatcggt 218641 cggcttgtgg acaaatgggg tgcccgggct gttttggcat ggagtgcgtt actgacagga 218701 gtcagcattt tcttaacata ccttgtgact tcgccttggc agctgttttt gctttacggg 218761 ctgggtgtct cgcttggagt gggcggagca tcgaatgtgg cggcaagtgt attggtcgtc 218821 aattggttca gcaaaaagcg gggactagcc tttgggatca tggaagcagg ctttggcgcg 218881 gggcaaatgc ttctcgttcc cggctcactc atgttgatcc attggtttag ctggaagctg 218941 acggttgtgg tgttgggact gctgttaatc gtgattgtct ttccggctgc gctgctgatg 219001 ctgcggaaca atccttcaga aaagaataca gagccgatag gcggactggc tgcatcagaa 219061 aaagaaacag cacccaaaac aacagctctt tcagtggccg ggatgtttcg tatgaggcaa 219121 ttctggttct tgatttttcc gtttttgatc tgtggattta cgaccgtggg gctgatggat 219181 acccatttga ttccgttttc tcatgatcat ggcttttcaa cgacagtcac gagtgctgct 219241 gtcagtctgc tagcaggctt taatattgct gggatcttgc tgtccggaat tgtagcggac 219301 cggtggagca gccggaaaat cctgtgcatt ttatatgcgg tgcgggcgct gtcgatcgtg 219361 attcttattt acagccacga gccctacttg cttttagcct ttgcgattct gtttggatta 219421 gtggactttg caacggtagc accgactcaa atgctcgcca cccagtactt tcaaaactac 219481 tcgatcggcc tcatgattgg ctggctgtca ctcgcccatc agatcggatc ggcactaggt 219541 gcgtatgtgc ccggcgtcat ctacacggta acgggtgagt atacactggc tttttatttg 219601 tcgattggaa tgctcgtgct tgcgagcgta atgaatgtga tgctgaggga gccagctgcg 219661 gttacgcgtg acagtgcggc tgtggtagac aagtgatgag gacaaaggga aagcatctct 219721 gatttcgaga ttattcagag atgctttttt tgtatttttg ttctaatacg aagtcgatca 219781 taccgactat gcgggcgttt tcggattttt gtttgaagcg ttcagaaatt tgaacttttc 219841 ttgaaaatgg ggaaacaata aaaacccaaa aaaggccgat caaggcaaaa aacatttgta 219901 cagctaattc tattaattca ttaaaacgag tgctgaaaaa atagaagtat aacgttatta 219961 atgtcacagt acatacgatt ttggcaagtg tgtttgaatg taagcaatgg ttcactaaag 220021 aataccttta attgattcag catgattgaa tcatatttgt ttaggaaaat aagaagttct 220081 ttatcatctt ttttatgttc taaaataaag ttgctgtttc tgtttcttta tatgtatggt 220141 ggtctacatt caatatatac atctcttaaa gtataaaaat tgagtatttc ttagtaagga 220201 tgaaacaaaa ttacatgatt tttttgttat atctttcagt tagaataaaa tctataactc 220261 ctctcattcg caaatattcg gctctctgtg caaagtgcag aacagtatgt aattgtcctt 220321 ttctagatat atttaaaagc tttatcaaat caataaggat tttcaagaaa ataattaata 220381 atagaaagat aaaaatgtgt ggtatgtcaa tgtaattgat ttgtcctgaa aataaagaag 220441 ttgcatagac aacaataata cttccgcaaa acatcaaact catataatgt ggaagggaaa 220501 atggacgagt tgaaaaatat gcttttaatt ggcttagcat agcattatct cttgtatcta 220561 agtagcccaa aagctcttta tcatttttac taattgtaag aacatgattc aatacagcac 220621 taaaattcat tgaatcttca ttatcagagg cagtatgttt attagcctgt atgttttgtt 220681 gatccatttt atatttttta taaagtattg tattaattaa cttgtttttc tcatagaatt 220741 cagatcgttg attaagggat gcttttcctt tgtttttatt tccttttttt atgattttag 220801 tataagtcat aaaaatacaa atgactgtaa aaatagaaaa cactgcaggt gaaatatctg 220861 aaagaatagt attggtgaag acttcttttg cttggatgaa aaggaaagaa gctaaagtca 220921 tagatataaa catgcataaa actgctactt tcacaagaaa ctgaagcgga agagaaggtt 220981 ccgaataata gtgcttcaac tggttgagtg tcagagaatc ttggcgaaaa agataatcta 221041 ttatctcctg ctgattttgc atctgattga tatcatgagc gatgtttttt gttttttcaa 221101 aaactatttg atcatttttc atttttgata aacctccaaa agacgataga taaactaaaa 221161 aaactgcatg agcatatttt aacttatgtt catgcagttt tgtattaaag ttagctagta 221221 taataagcaa aaatggccag taacatagca gataatgcgg tagcgacttt gactccttta 221281 ttgttcgtta aatcactgcc catattccca attagtaaaa gtgcagcaac acctacaaca 221341 gggaataaat attgatcata agacggccaa tctaacgcta attcactctc gggagacgta 221401 actggtactc ccttgtacgt ctttatttta aacgtaatcg tagtcgttag tccagttgtg 221461 acattgtcac cgactggaat atcaggtgta tagattttaa tttgaatgtt taaagattca 221521 gctgttggat ttacataaac ctccaaataa ccgttgcgta ctgataagct cagactattt 221581 aaaaggtttt gataagagtc gatttgtgac gcagtgagag acgtttgagt gtcgcccaat 221641 aaacccgtga tataggcacc tggtttacca tttgtaatgg taattgtgtt tggtgaacct 221701 tcacttggta tggttgccag aagtgaagtt gatagaataa tatccaactc aggtgatgtg 221761 aaaatggttt ctgtcgtatc aaattcaaac atcgcgtttg ccagacttgt tagattttct 221821 aaagctggaa tggtagataa aatgtctgtc agtgtacgca gtcttgcatc atataccgga 221881 tcagacggcg gatttacatt gcttgcacct gagtctcttc ctgaataccc gtctttatca 221941 atcccgatgc ttccagagcc gcttccgatg gttccttcat aaaattgatc aaaggcccag 222001 ttgtttggca tcggatagcc gagattgccg ctaaatcctg ttgacatatt tgccacaaaa 222061 ctatactttg tcagtcctgc ttcagatgta cggatacaaa tgtttcttgg tccgtaaacc 222121 cctatttcat acttaggtgc ggttgaaaat gtctgcattt ttgtaaatgc tgacttaatc 222181 tcttggaaat aaggaatgat tttatcggtc acttcataat cgtatgcatc aaaatcgaca 222241 gcgaaataaa tggtcgtgcc tgacggaaaa cctaatcttc tagcagcaga agcggcacta 222301 tatgcatctc ttgtgccttg gtctttgaca aaataagaag attcatagcc gccgtcttga 222361 taaattggga aaaccttcaa tccggcatca agaataactg caagctcttt agatgtcagg 222421 gctttagatg tgaggccgct gcttgtccgc acatttccgg tcaaatatct gccaaccgtt 222481 ttataaccgt tattccgcag tgtttgagct ttttctgcgg ttataattgt agcagtgtca 222541 caagcagaag cggtgcgagt tgtgtctcct gagcttgata ataaagcttt aatggttggc 222601 atatctgcat aacctgtttg cggcaggcac atgaactctt gaaatgcttt aacagctgaa 222661 acaacaccca caccatattt gccgtcaaac tcaccaggat cgaacgattt tccgttacaa 222721 tagagggcgt actgaacaat taagacaaat cctgttcttg aatcgccggg agttaaagta 222781 gggcacaaac ttgtggtgcc gtttccgaaa aatccattgg caacacttgt gctcatgcct 222841 tcttcttttt gcagggcata aataagagct ttatttgtat cgcggccata cagtccgtca 222901 caaggcatta acccgatata gtcattgtag tctcgattta agttttgttg aatctggcga 222961 attcttgaat cacccccaga caccagctta aaagcgctca tgtctaataa ggctttcata 223021 attaacgtgg tgacaatccc atcctgtgtt gtcagtccgg cagctttttg aaattctttt 223081 accgcatttt ctgttttttc gtaaaagacg cctgtaaaac cgccgggatt aaagccttta 223141 caccataaag ccccttgtaa aataaaattc atgttgcttg gttttgaatc tggagcttgg 223201 cgtttaagag gcttaaataa gcgctgtgtt gtcggcccga agttatcggc tggctctgag 223261 atacccaatt caatttgaag cgcccgagtc agaccgtaga tcgtatccca cccagttttc 223321 ccgctttctt caactgggtt atacccatgt ttgccgctgt acgtatcgtt cagccattgc 223381 tgtgtgatta agaccatttc atcaaccatt tcgattcctc ctttgttaga ttgcgttcat 223441 ttataggtgg caaacgtagg acaaaataaa aaaatggatg ccgttaagca tccattttac 223501 atccgttctc caacagcttc gctttcggtt tcagctctga aatgtagagg cctaaaagtg 223561 taagcgcgcc tcctagaaga gcgatccatg tcatgttttc gtgcagaatc aggacagaag 223621 cggcgatcgt gataaccggg accatgtaaa tatacgcact ggatttgacg gctccgagca 223681 ctccaactga ataattccaa gtggcgaagc acagggcaga agcgccaatc cctaagaaaa 223741 gcatgttgag tatatttgaa gcagatgaaa atcggcttag gtcaaaatgg aagtcgaaca 223801 aaaataaagc gggaaccata aacaataaac catacaaaaa tactctctgt gtcagctcga 223861 tgatgtggta ttcgtaggcg cttaattttt tcatgaatat cgagtatccg ccaaacacga 223921 gagcagcccc ggctgccatg atgtctccga gcggatttag acgcagtacc acattgccgt 223981 taaacgtaat caataaaagc ccgatcagtg ccgagataaa tccaatcaaa aaagtcagac 224041 gcaatttttc gccttcgagc agaaaatggg ccaaaaccgc agtgatcatc ggtataatgg 224101 acacgatcat gccgacattg gaggcgtatg tataggtgag agctatattt tctaatagaa 224161 agtataaggt tacgccaaat aaaccagctc cggcaaacaa cagctcctgc cgccaatttc 224221 tgaacggaat catgttggga cggacgagga taagagcgat aaagcccatc aaaaaccgat 224281 aaaataatat ttccattgga gagaagtcag ccagcagaac ttttgtcgaa ataaaggtcg 224341 tcccccaaat cagaatggtc acaatggctg cgatatgccc cgaagtttct ctttgtatgt 224401 tcatctgtga agctcctttt caaaaatctt catgtattgc ttcggcgtca gccccacctg 224461 ccgtttaaaa aacttcgtca tatgactctg atcgctgaat cctgtctgaa atgccgcatc 224521 aatcggcctt accccttgtt caaggagttt tttggcttga ttaatccgga ttgtttccat 224581 gtagctatta ggggtaatgc ctttttgttt tgtaaatgaa cgcaataaat gatacttgct 224641 ccagcctgtt aattcactca aatcattgag tgtaacattt tcggcataat gctcttctaa 224701 aaattcacaa accattttga cttcgtctga tggttctgga acgctgctaa ggaacgtgac 224761 atctgaataa tggcggatca gctcctctaa tagatgaaga aacagctcct ccttacgcaa 224821 agcttgtttt tcctcggata tcaaaatatg caattcctgc aggctggctg tcagctcatg 224881 gcggaataac acatgctggg agaaataagg gagatgcccg gagccagtaa tctctttcac 224941 cgccttctcc atgatatccg gcatgacatt gatacaccga taatcaagcg tccggccgtc 225001 aatctgttca cagctatgcg tgtcacgggg gttaaagagg agaagatcac ctggattgat 225061 gatatattct tgatcctgac aggccagata ccgttgccct ttttcaataa atccaatcac 225121 ataataatcg tgaaagtggt tcgggaactt ctgcataatt cccttgaagc ggtaggcttc 225181 tatatgaagg tgtgggtcaa gctgcagtgt gcgggtttcg ttttgcatgg gatgcctcct 225241 gtcggtgtgg tggtcttgga ttaagtgtag catgattttg ggggatttct tgtatgatgt 225301 tgctgtttag gaatagagaa agcagaccgt tatttgtctg ctttcgttta agaatttaaa 225361 agattttaac cctcaataat aattttatct tttttaataa aaatttattt ttcaaatatt 225421 tcagttataa tggtttggaa cagataggag gggcaaagat gtatcaatca aagaaggttt 225481 tattgttagg ttcaggtgaa ttaggtaaag aggtagtgat tgaagcccag cgtcttgggg 225541 tacagacggt ggcagttgac agttacgagc atgctccggc gatgcaggtc gcgcataaca 225601 gttatgtcgt tgatatgctg gacccagagc agatcagaac catcattgag aaagaaaatc 225661 cggatttgat tgtgcctgag gttgaggcga ttgcgacgga tgaattgctg aagcttgaag 225721 aggaaggatt tcacgttatc ccgaatgccc gtgcggccaa gctgacgatg gatcgggaag 225781 gcatcagacg acttgcggcg gaaacgcttg gacttgcgac agctggctat gaatttgcga 225841 atacatatga tgaatttata caagcggcag ctcagatcgg ttttccttgt gtcgttaaac 225901 cattgatgag ttcttctgga aaaggccaaa gtgtgtgccg ctctgaagcg gatttagaga 225961 gctgctggga gacggcgatg gaaggcggac gggtgaaaaa cggccgcgtg atcgttgagg 226021 agtttatccc tttcgaatca gaaatcacac tcttaaccgt acgtgcggtt aacggtacgg 226081 cattttgtga gccgatcggt catgtgcaaa aggacgggga ttatatcgaa tcgtggcagc 226141 cgcatgatat gacagagcag caaatagaag aagcgaagca tattgcgaaa acgatcacgg 226201 atgagcttgg cggatacggc ctgtttggtg ttgagctgtt ccttgcgaaa gatagggtat 226261 atttcagtga ggtatctcct cgtccgcatg atacgggtct tgtcacgctg gtgacgcaaa 226321 atttgtcaga atttgcgctg catgtccggg cgattctcgg ctttccgatt acagaaatca 226381 cacagctttc tcctggcgcc agcaggcccc tcaaagcgcc ggaagaatta gcggattaca 226441 ctgttgaagg attggaaaac gcactggcag tcccaaagac tcaagtgcgc gtctttggaa 226501 agccgataac aaaagccgga cgtcgtatgg cagttgcgct ttctgctgct gattcagttg 226561 aaacggcaag agagaatgca aagaaagcgt tggaccagct aattttaaaa tagagtttga 226621 acaggtcttg tcatgggaca aggcctgttt ttttctttct ccgtaaaagt tttatcataa 226681 gaatcagaaa cctgattata atgtaaaagt cttccatcga tacgggtggt tgacactaaa 226741 ggagggagat gacaaaatga aattagttcc aagattcaga aaacaatggt tcgcttactt 226801 aacggttttg tgtttggctt tggcagcagc ggtttctttt ggcgtaccgg caaaagcggc 226861 agagaacccg caaacttctg tatcgaatac cggtaaagaa gctgatgcta cgaaaaacca 226921 aacgtcaaaa gcagatcagg tttccgcccc ttatgaggga accggaaaaa caagtaaatc 226981 gttatacggc ggccaaacgg aactggaaaa aaacattcaa accttacagc cttcgagcat 227041 tatcggaact gatgaacgca ccagaatctc cagcacgaca tcttttccat atagagcaac 227101 cgttcaactg tcaatcaagt atcccaacac ttcaagcact tatggatgta ccggattttt 227161 agtcaatcca aatacagtcg tcacggctgg acattgtgtg tacagccagg atcatggatg 227221 ggcttcgacg ataaccgccg cgccgggccg caatggttcg tcatatccgt acggtactta 227281 ttcaggcacg atgttttact ccgtcaaagg atggacggaa agcaaagaca ccaactatga 227341 ttacggagct attaaattaa acggttctcc tggaaacacg gttggctggt acggctaccg 227401 gactacaaac agcagcagtc ccgtgggcct ttcctcgtca gtgacaggat tcccatgtga 227461 caaaaccttt ggcacgatgt ggtctgatac aaagccgatt cgctccgctg aaacgtataa 227521 gctgacctat acaaccgata cgtacggctg ccaaagcggc tcgcctgttt atcgaaacta 227581 cagtgataca gggcagacag ctattgccat tcacacgaac ggaggatcgt catataactt 227641 gggaacaagg gtgacgaacg atgtattcaa caatattcaa tattgggcaa atcaataaat 227701 acagcaaact agccatattc atgtctattt tgtttttatg cgggtgcagt tcgcagacgc 227761 attcttctca aaaagaaacg actattcctg tcactcttca tgtggaggat gctaaggggc 227821 tgccggtcga aggggttcaa gtgacgattg tcaaagcgcc ctcttcagat gaggagccga 227881 gtacagagat tggcgagata ctcggtaaaa cagacaaaaa cggagatatc aaatgggata 227941 ccggcagaaa aggcgattac tcagtcgcgt tgacgaaggg tgaaacatca gtaacccatc 228001 acatctcgtt aacagaggat aaaaaagatc atgccattcc attagtcttc aaagaatagc 228061 agtttccttg attttaaggg aactgccttt tttatttatt gcaggaaacc aaactatata 228121 ctggaaattt attatgtgag ataataagaa ataggtattt tttcttacga gacaaaaggg 228181 gcgttatcct ttatatcaat caaacccgga ggaaaaagaa gaagatgata caagattcaa 228241 tgcagtttgc cgcggttgaa agtggtctgc gcttttacca ggcatatgat caaagccttt 228301 ctttgtggcc gattgagtcg gaagcattct atgtttctac tcgttttgga aaaacacata 228361 tcattgcaag tgggccaaag gacgcacctt cgctcatttt gcttcacgga ggccttttca 228421 gctctgcgat gtggtatccg aatatcgcag cgtggagcag tcaatttcgt acatatgcgg 228481 tcgatataat aggagacaaa aataaaagta taccatcagc agccatggaa acgagagctg 228541 attttgcaga atggatgaaa gatgtctttg attctcttgg acttgagacg gcacatctgg 228601 ccggcctttc gcttggcggg tcccatatcg tgaatttctt actccgcgcg cctgaaagag 228661 tagagcgggc ggttgttatc agtcccgctg aagcgtttat ttcatttcat ccggatgtct 228721 ataaatacgc tgcagagctt acaggggcaa gaggagctga atcatatatc aagtggatca 228781 caggcgacag ttatgatctg catcctttac tgcaaagaca aattgtggcg ggcgtggaat 228841 ggcaggatga gcaaaggagc ctgaagccga cagaaaacgg ctttccgtac gtgttcacag 228901 accaggaatt gaaatcaata caagtcccgg tacttctgat gttcggtgag cacgaggcta 228961 tgtaccatca gcaaatggcc tttgagcggg cttcggtatt ggtgccggga attcaggctg 229021 aaatcgtaaa gaacgccgga catctgttat ctctggagca gccagagtac gtcaatcaac 229081 gcgtcttgtc ctttttatgc ggggggataa aatagtaagg aacatgaaaa gattggcatt 229141 catttttcaa aaggtaacaa atgttgtata ataatagaat ttgaatgctg ctttttttgg 229201 gagcattcta tgttatcatg cttattggag aaaaattttt cctgtaacgc tattcgatca 229261 ctatcgtcaa ataatataga tggttttaca attggaggtt tggttacact gtgaattaca 229321 tcccctgtat gattacgata ggaaacttca tttgcggatt gctggcgatt cattccttgc 229381 tatatcacaa cattcattca gcagtgcttt ttatttttac aggcatgttc cttgatttct 229441 ttgacgggat ggctgctcgt aagctgaatg ccgtttctga tatggggaga gaactggatt 229501 cgtttgccga tctggttacg tttggggtgg ctccttctat gcttgcttac agtgtcgcgt 229561 tgtataccct gccatttatc gggatcttat gcgcattgac gtacagcatt tgcggaatgc 229621 ttcgcctctc taaatttaac attgaacaaa gcaagctccc gacgtttatc ggtatgccga 229681 ttccgtttgc gggcatgtgt ctcgttattc taagcttcac ctataacccg atccttctgg 229741 caatcggcac ttgcggactc tcatatttga tggtgagtaa aataaaattc cctcatttta 229801 aaaaacatgc ggcagaaaac ctggagtctg ggagatggaa ttagttcagc agctcatagc 229861 ggattacggt tatctcgcta tttttttgat gctggtatta ggaattgtag gattgccgat 229921 tccagatgaa gtgatgatga ccgttgttgg ctatttcacg cataccgatg tattgaatta 229981 tgagctttcg atattgatta gttttgtcgg ggctttgtta ggtatgctga tcagctacat 230041 gattggcaga aaagccggac gcccgtttat cgacaagtac ggcaagtggg tcggcttaaa 230101 agaaaaaaga atgatgaaag tggaaaaatg gatgaagaaa tacggtccat attctcttat 230161 tttaggttat tttattcccg gcgtcagaca tgtgacgtgc tacttttcgg ggatcggcaa 230221 aatggatctg aaaacgtatg ttgcgtttgc tgcaatcggc gcctttttat ggtgctttgt 230281 ttttattaca atcggaaggg ttatagggat tattcatgtt taatacggct gtaaagattc 230341 tgtatcgatc attgatagag ctgacgaatc atcgtctgtc atcctatctg attaaaggat 230401 tttgcgagtc gaaaatcagc aaaccggtca ttccgctttt ctcaaaacat tttcggctga 230461 attgggatga tgtggacggt acggctgctg attacggatc gctgtccgaa ttgttcattc 230521 gacaaataaa tctggagcgg cgccctgtgt caaaagaggc gcatgcggtg gtcagccctg 230581 ttgacggtgt ggttcagacg gtaggaatca tcaacccgaa tcaaaccttt acggtgaagg 230641 gaaaagatta ctcattcgct gagctgaccg gctgtaaaag cgcagaccat caatacaacg 230701 gcggatattt cgtcgtgctg tatttaagcc cgaggcatta tcaccgtttc cattctccga 230761 tcagctgcag gtatcaaaag ctggccgagc tcggaaatcg ctcatacccg gtaaatcaac 230821 taggcttaaa atacgggaaa gatgtgctgt cgaaaaatta tcggtttgtg tacgagctga 230881 atagcggcag ccgaaatgtc ctgatgattc ctgtcggcgc gatgaatatt aattctatcg 230941 tgcagacgaa tacccgtact gaattggaga tcggcgagga gctgggatac ttttcatttg 231001 gctcaaccgt cattttggtt tttgaaaaag acgcgttcca gccgtccgcc catttagcag 231061 aaggccaaga agtccaagtc ggagaactga taggttacga agaataaaaa gaggagcttg 231121 cataaacgca gcgcctcttt ttttgaagaa aggtgagatt catggagaaa caaatcatca 231181 gctggattac agattatcag aacaccggag atgaagccgt cctgcggcaa gtgcgagaag 231241 tgtgctggcc gatcgttgaa gcggttttgc aagagaaagt aatggatgat gaacaagcga 231301 acaatttgcg cgaaaaagga atcgagcggt ttccattcat catcagcaaa taccaagcgg 231361 atgtgcagct tccggttgag acatttttac aaaatacgta tcggttttac tttcatcagg 231421 tgatgagaga atccagctaa agcttctttc aacagagaag cttttttttg ttggcaggaa 231481 aaggaaactt tttctatatc tatctcgtaa tgactagaga acctagcaga aaaggagaga 231541 tagaattgaa acgaatgata gtgagaatga ccctgccgct gctgatcgtt tgtctggcgt 231601 tttcttcttt ttcagcctca gcccgtgctg cttctgaaga aaaatattgg gatcactgga 231661 ttgaacgaca tgcacagcct ctggatgctt ccaatgcttc aaacaaagac cttcgatttc 231721 taaaaaaggt gctgaaggga aaacgaatcg ttcagttagg agaaaccaca cacggtgctg 231781 gcgaaatcaa tgccacaaag gtcagaatga tcaaatacct ccacgaagag ctgggatacg 231841 atgtattggc ctttgaatcc ggctttcctg atacaaatgc atcctacctt aatatggacc 231901 aattaacccc taaaagcacg atgaaaaact ccatttacgc tgtatggcac acagaagatg 231961 tcgtcgaatt gtttgattac atgaaagagc aaaaagagaa aggcgatccg ctgatcctta 232021 ccggttttga tattcaaagc atgaagaatt cattcaatgt agctgcgact caatgggtaa 232081 aagcggtgga ccctgagaaa gcagagttgc tctcccaatc agaaaatgat ttttcaacat 232141 tagtgacaga cagcaatacg tttgatgaat tttcgcaaaa gaaggaaaag cttgtgaaaa 232201 actatcagaa gctgatcaag ttcactaaaa cacatgcttc agagctaaaa gaaaaccttc 232261 caaaagagcc gaaagcttat gagatgttta tgcattctct tcagctgaga attgacgtaa 232321 tggaaacata tatgctggaa gaaatgaaag aaaaactaga ggagtatccg gagaatattg 232381 aggatttttc attctttatg agagaccgca tgatggctga acaatttcag tgggtagccg 232441 acacccttta tccgaaaaag aaaatcattg tctggggcca caattaccat ctacgcaaac 232501 agaatacgaa gatgataaag gactgggtac agctaaacgg ccctaacatg ggtgattatt 232561 tgccggagcg gctgaaaaaa caaacatata cgattggcat ttatgcttac tcaggtgcga 232621 gtcttgatag ctccgataat aagactgtta agccggttac aagcccgccg ccgtctggga 232681 gccttgaagc tttgctgaaa gcggcggacc gaccggctgt ttttgttgat tttctccata 232741 caaaaaacaa gaaaggcact tcgtggatgt ataccccgcg gactgcgctc tattgggggt 232801 acatggaaga gcagatgatc ctgaaggaac aatatgacgg tgtcatttgg ctggagcata 232861 tcacgccctc tgtcattatc aagtgagcgg tgtcccctgt ggtaaacagg ggatttttac 232921 atatcgcaaa aataatcaaa acatataatc cgtgatccat tattctaaaa cagaaaggag 232981 attggagcgt gcaatgtatt atgaaaaagc tgtccagaaa acaatcaatt ggattgaatc 233041 acatttacat gagcaaatat caaacgagga tattgttaac gtttcaagct tttcaaaatt 233101 ccattttcat cggatttttc aaaaagaagt cggcatgtcg gttgcttctt atattcggtt 233161 aagacgtctt gcgaatgcgg cggcagcttt gctttataca gatcatcgta ttatcgatat 233221 tgctttgtat tatcagtttg aatctcaaga agcatttacg aggacgttca aaaagatgta 233281 tcacatgccg ccaggagcat accgaacatt tatgaaacgc tttacttcaa aaaaggagga 233341 atcttacatg gagaaaaaaa tgaaaggctg ggtattgagc gggagccatc cgttccaatt 233401 cgaaatgggg attgaccggg aaaatgtaca tcagggaaaa gcttcagggt atttaaagtc 233461 aacgatggtt caggatatcg gtgaatttgc gacgatgatg cagcaattca aagcagatcg 233521 ctatctagga aaaaggcttc gtctatcaag ttttatcaaa acaaaggggg tgcagcattt 233581 tgcctcactt tggatgcggg ttgacagtgc tgctgatgat gttctccaat ttgataatat 233641 gagcaacaga cctattaccg gaacaaccaa ttggaatcat tatgctatcg ttttagatgt 233701 cccagaaaat agcgctgtga tatcttttgg cgttcaatta tctgggccgg gtcaggtgtg 233761 gatggatcat gttgtttttg aagaggtaga tgagagcgtt ccttcaacaa accttgaaat 233821 gccgggagaa cttttagatg aaccggtaaa tttatctttt gaagaggaac tacaaaaata 233881 gttttcagac aactactttt attagtgagt taatggaaaa tactatttgt tattaataaa 233941 cccttgtgct gcttaggttt gtaagagctt ggatattttt atcagtctgg gcggatctgt 234001 tcatctttgc ggcattttcc tgtatgatat agtaagagtg tgcatagcaa ctaactataa 234061 ttgaacaggg tgtttaaaac atggaaaaac aatacagagt attactttac tataaatatg 234121 ttccgattga agatccagag gcgtttagag agcagcatct ggctttttgt aaggagcttg 234181 gtttgttagg ccgtatcctt gtttcttctg aaggaattaa cggtacggta tcaggtacgg 234241 ttgaacagac tgaaaaatat atggaaacaa tgaaagctga tcctcgcttt gcggacatgg 234301 tatttaaaat tgatgaagca gaaggccatg ccttcaaaaa aatcttcgtc cgccataaaa 234361 aagagcttgt aacgcttcgt cttgaagatg atgtcgatcc gaacgaaaca acaggccagc 234421 atttgaagcc tgcagaattt tatgagaaga tgcaggatcc aaacacaatt gtcatcgacg 234481 cgcgtaacga ttacgagtat gaccttggcc atttcagagg tgcggtccgt cctgacatcg 234541 aagccttccg tgaattacct gaatggattg aagagcacaa agatatgctt gaaggcaaaa 234601 agattttaac gtactgtaca ggcggcgtgc gctgtgaaaa gttctcagga tggctggtga 234661 agcaaggctt tgaagatgta gctcagcttg atggcggaat cgtgacatac ggaaaagatc 234721 cagaggtgca aggcaagctt tgggacggcc agtgctacgt atttgatgaa agaatcagcg 234781 tgcctgtcaa ccgtgtcgag catgtgattg tcggcaagga ctactttaca ggagaaccgt 234841 gtgagcgtta tgtgaactgc gcaaatccat cttgcaataa aaaaatgata tgcacaccgg 234901 aaaatgagta taaatatatg cgcagctgca gccacgaatg ccgcacgaac ccaagaaacc 234961 tgtatgtgaa agagcataat atgacagaag aagaagtaaa cgcaagactg gcagcgattg 235021 aaacagaaga tcacgctgct gctgaataaa aaaagaacac ctcgtattga ggtgttcttt 235081 ttttctatat gctttcagtt tggctgtttg cggaaaccca ttctttttgg cggaaggcct 235141 tttcccattt tgataccacg atacaggcga tcgcatgtcc cggtacgttc acgcctgttc 235201 tcgccatgtc catgacgcgg tcaacacccg cgataatggc aacgccttca gccggcagtc 235261 ctacagcatt ggcagtcgcc agaagaacta caagcgatcc tgagggtaca gctgcaatgc 235321 ctttactggt catcacaagc acaagcatca tgagcagctg ctgggacaat gtcatgtcta 235381 cttgaaaggc ctgtgcgaga aagatacaag aaaccgataa atataagctg gagccgtcac 235441 agttcaatga caagccggag ggaacgacaa atgataccac tcgtttggga cagccgtatt 235501 tctccattct atccatcagc tgagggagaa tggtttcagt gcttgtggtg gaaaatgcaa 235561 ttaaaaacag atcccatatc attttcaata cttcgaaata cttaatctga aagatgagac 235621 cgacaagcgg aaagaggaca aagaggatca ggaacaggcc aaggaatacg gtgccaacca 235681 gcttaaacat agggaggagg agttcaatgc catattggcc tacagaagca gccatcaggg 235741 ctaacacgcc gataggagca gtgaccatga cgatttgcgt gagcttgaac ataatctgag 235801 ctgtagattc aaaaaacttc attactggtt cagaagcttt gccgatacca gctgcggcga 235861 caccaaataa aatggcgaag aaaataacgg caagcaaatc atttctggcc atgacatcaa 235921 taatgtttgt agggataata tccaggatca tttgcttgaa atcaacaact ttgtctgtgt 235981 agccggaaag ttcatgaata tctttttttg ccaaatggga gaggtcaagc ccgacacctg 236041 gttttaagac attcgctaat aaaagtccaa gccctaatac caacgttgta atcacttcga 236101 accaaatgat cgtcttgatg ccgagactgc ccattttttt catgcttccg cttcctgcgg 236161 ctccaatgac aatggtagaa aatacaatcg gcacaacaat cattttaatc aggcggataa 236221 atccatctcc gacaggcctc agtgccatcc cgaaatcagg aaaaaagtgg ccgatcaccg 236281 cgccgacagc caaagcgatt aaaatttgaa acgcgattaa ttttttcaaa tgaatccccc 236341 tttagaacga tagaatgtag gcatattcat atcattcgtg attcaaatgc aaacaccttt 236401 tttcaagtta ttttattttg acagcgcttt cattatgttg gcgaaaaagt cccccgcagc 236461 aggggggact tttttacttc atttgaatgt gctttagatc ttcttcagag gtatttgtga 236521 aaataaccgg tgttatggct gaagcggcat gctgcttgat gtaattgaga tcaaaggtga 236581 gaagcagttc gccttgtttg acggcttgtc cgcttgtgac atgtgcttca aagccttccc 236641 cattcagttt gacggtatcg atgccgacat gaatcaggat ttcagtgccg ccggcgctca 236701 taaagccgat ggcgtgtttt gtcggaaaaa tcgagacgat ctcgccgtcc gcaggtgcaa 236761 cgacttttcc ttctgatggt ataatcgcaa atccctcgcc catcattttt tctgaaaaga 236821 cctgatcagg cacatcccct aaagagactg tttctccttt aatcggataa ataaaggtct 236881 catcggaatc gggcttcagc ggtttgtcag ttaccgtgtc cagcgcggcg gcggtggcag 236941 ggacgcctcc ggccatgatt gttttgatgt cgtcttttaa ggcatcggac ttggttccga 237001 atattgcctg gaagttgttg ttgacctcca gcacacctac tgcaccaagc cgttttaatt 237061 catccttgca gacttggctt ggctgatgaa cggtcacacg aagccttgtg atacatgcat 237121 ccaggttagc gatattttgc tgtccgccca aggcctgcag cacgtgaaag gcaagctggt 237181 cttttgcaac tggagctttc tcctcattct gaccgtcttc atctgtctca cggccgggcg 237241 ttttcaaatt ccatttcaga atcgcaaatc ggaacaaata ataataaatg aaagcaaaca 237301 cgatcccgac aggaatgaca acccagccgt ttgtagacag tccgtagttc aagacgtagt 237361 caattcctcc gcctgagaac gtatagccgt ggcggacatg gaataaatca caaacgacaa 237421 agatgacgcc ggcaagaata gagttaatca aatagagcac gggcgcaacg aacaagaaag 237481 aaaactcaac cggttctgta attccggtca gcatagatgt gagcgccgca gaaatcatca 237541 cgccggagat catttttttc ttttccggac gcgcggtatg gataatggca agagcaacgg 237601 ccggcagaca gaaaatcatg taagggaaat cccccatcat aaagcgcccg gctgtcgggt 237661 ctcccgcgaa aaaccttgtc aggtcgccgg ttacggtgtt gcctgttgat gggtctgtgt 237721 attctcccat cataaaatag aaaggcgtat aaaaaatatg atgcaggcca aaaggaatca 237781 gcaaacgata gatcgttgca taaaagaaca ggccgactgt tgaatcggca attaaactgc 237841 tggctgcgtt aattccgttt tggatcagcg gccaaacgaa tgagaaaatg acgccgatca 237901 ccaatgaact gacggaagta atgatcggga caaagcgttt tccagagaaa aatccaagga 237961 ccggatgcag ctcgattgat gaaaatcgct tatataaata ggcggcgaga agcccgataa 238021 tgattcctcc gaaaaccccc atatcaatca ggtgctcggc tccttcatac ggaggctgaa 238081 ggccgagtaa ttttcccata ttgtcgaggg tgacggttaa aattaagtat ccgatgacag 238141 cggcaagtcc ggctacacct tctccgccgg ctaatccgat cgcgaccccc acggcgaaaa 238201 tcagcggaag gttatcgaat acaacgccgc ccgcatcctt tataataggg atgttcagta 238261 aatccttgtc tccgaaacgg agcaaaagac ctgctgccgg caggacggca accggagtca 238321 tcaacgcgcg gccaagctgc tgcagaattt gaaatgcctt tttaaacatg acagtctcct 238381 tttattgtgt tatgagaatg atgcactctt taatttttga gctgctttat aatcggcgat 238441 aacggttaca tgattgtgtt tttgaagaat ggaggctggt acatctgtcg tgacaggacc 238501 ttcagccatc ttttgaatgg cgtctgcttt ttcctcgccg cttgctaaaa gcacaatatg 238561 tttgctgaat tccatgatgg ttttaatgcc cattgaaatc gcgagtctcg gaaccagcac 238621 cggatcgccg ccgaagaatc tggcatttgc ctgtatcgtg ctttccgaga gcttcacaac 238681 acgtgtccgg tcttcaaaat cagatcccgg ttcattaaaa ccgatatggc cattggcgcc 238741 gatgccgaga atttggacat caatgcctcc cgcctggcgg atgagatcct cgtatacttt 238801 gcatgccgcc tcaagctgcg gattgtctcc ttgcgggata tgaatatgat caggctgcat 238861 attgatatgc tgaaaaagat gctcatgcat aaaatggtta taactttgcg gatgagatgg 238921 agagagacca gcatattcat ccaaattaaa tgtagtaacc tttgaaaaat caatttcgcc 238981 tgcctgatag tctgaaatca actgcttata caagccgacc ggtgtgcttc ctgttgccag 239041 gccgagaacg gcatctttct tagcttgtat ttgttcttta ataatggcag cgcttaactt 239101 acagagttct tcgtagtgct cggcgatcag aatcttcatg tgacaccccc tcaaagagat 239161 agacaagcac catatttgtt atgaccaatt tatgatactt gtcattacga atttagcacc 239221 gcccttatca aactgtcaat attaatttct gaaaatttgt tataaaagaa ggatacaaat 239281 ctttcatatt gggagggcaa atggtattat ggtctcaatg aaaaagaacg gattgcatac 239341 agaatgggga gaatgaaatg acagctttat attctgttat caagtttaaa atcattgagt 239401 taattaaatc gggcaaatat caggcgaatg atcagctgcc gacggagagt gagttttgcg 239461 aacaatatga tgtcagcaga acaactgtga gactggctct gcagcagcta gagcttgagg 239521 gatatattaa aagaattcaa ggaaaaggga catttgtatc ggcggccaaa atacaaacgc 239581 cgattccgca taagattacg agctttgcag aacaaatgag aggacttcgt tctgaatcaa 239641 aagtgcttga gcttgtggtg attcctgccg atcattccat cgccgagctt ttgaaaatga 239701 aagagaatga acctgtcaac aagcttgtca gagtcagata cgccgagggg gaacctttgc 239761 agtatcatac ctcatatatt ccctggaagg cggcaccggg gctggcgcag gaggaatgca 239821 ccggctcgct gtttgaattg ttaaggacaa aatacaatat tgaaatcagc aggggcacgg 239881 aatcgatcga accgatttta acggatgaaa cgatcagcgg acacttatta accaatgtcg 239941 gagcgcctgc gtttttatca gaatccctta cctatgataa aaatgaagaa gtggtggaat 240001 atgcgcaaat tattacacgg ggagaccgaa cgaaattcac cgtagaacag tcatatcatt 240061 cataaagcaa tgtgttttaa gaagggaatg gtggttctat gtttttattt acgaatggaa 240121 aagtgctgtg gggagcagtg attgctgcat tcatcctttc aattgtattt tacccttttc 240181 tgccgacgca gatgccgatt cattatgatg ttgcgaacag tccggatctg acggttaaca 240241 agctggcggg gactgtgatg ctgcctgttt tgatggtggt gtttgcatgg gcgcggaaga 240301 tcaattggca atttgtattc gcagtgtata ttttgctgat ttgccacatt gtcgtccttt 240361 gtttagcgct ctaaatcaaa cagccagaat aaaactggct gttttcttta atttcagctt 240421 catctgacaa tgaatgtggt gtataatagc tgatgatcct aaagaatatt ctgaaattta 240481 taggtgtgaa gcggcgtatt attaaaggaa aggctgtata ctttttgcag ctttaaaaag 240541 actgaatatt taaacaatta tgtgaaaggt gtgctgatta gattgaataa gcttattgaa 240601 cgagaaaaaa ctgtatatta taaggaaaag cccgacccgt cttccttggg gtttggacaa 240661 tattttacag attatatgtt tgtgatggac tacgaagagg ggattggatg gcatcatccg 240721 agaattgcgc cgtacgcacc gcttacgctt gatccgtctt catctgtttt tcattacggc 240781 caggctgttt ttgaaggatt aaaagcatac agaacagacg acggcagggt gctgctgttc 240841 cgtccggatc aaaatatcaa acggctgaac agatcgtgtg agcgcatgag catgccccct 240901 ttagacgaag agctggtgct tgaggcattg acgcaattag ttgagctgga gaaagattgg 240961 gttccaaagg aaaaaggaac gtcactgtat attcgtcctt ttgtcattgc cacagaaccg 241021 agtctcggtg tgaaggcatc caggagctat acatttatga tcgtgctttc gcctgtcggc 241081 tcctattatg gcgacgatca gctgaagccg gttagaatct atgtcgaaga tgagtatgtg 241141 agggcggtca acggaggagt cgggtttgca aaaacggctg gaaactatgc cgccagtctt 241201 caggcacagc ggaaagcgaa tgaactgggc tatgaccagg tactgtggct ggacgccatc 241261 gaaaagaaat atgtggaaga agtagggagc atgaacatct ttttcgtcat aaacggggaa 241321 gctgtcacac ctgctttaag cggaagcatt ttaagcgggg ttacacgtgc gtctgcgatt 241381 gaattgattc gaagctgggg cattccggtt cgtgaagaga gaatatcgat tgatgaggtg 241441 tatgcggcct ctgcacgcgg agaattgaca gaggtctttg gcacaggcac ggcagcagtc 241501 gttacgcctg tcggtgaact caacatccat ggaaaaacgg tgattgtagg cgacgggcaa 241561 atcggggacc tctcgaaaaa gctgtatgaa acgataacag atattcagct tggcaaggta 241621 aaaggcccgt ttaactggac agtggaagtg tgaaaatcga aaaagaacct gcccggaggc 241681 aggttctttt tattttgaat gagtcatatc agcagccggc tggcttttgc ggttttttac 241741 ataatatatt gcatagcaaa tggccataaa tggaacgccg caatagagtg cgattctttg 241801 attcggatca aaggcaatgc caacgacgga agccaggcat aacaggaacg cagcaatcgg 241861 cacgaacgga tacaaagggg ttctgtattt caaatcagta accttgtttc ccgcttcgat 241921 ataacgtttt ctgaacatga attgagaagc agcgattccc atccacacga caacgacggc 241981 aaaaccggaa atcgacacga gcacaacgta tacagtgtct ggcgcaaata cgctggacag 242041 caacgacaga atgccgccga tcatgctgaa caccagcgcg ttaaaagggg ttccttttga 242101 cgtcagcttt gcaaatgtcg gatgaagcgt tttttctttt gataaagacc acagcatccg 242161 ggaagaagcg tagagtccgg aattagccgc tgacaggatc gctgtcagga taacaaagtt 242221 catgatatcg gctgcgtatg gtacaccgac tctgtcaaag acagcgacaa acgggctttt 242281 gatgacacct gcatcttgaa tcggaatcag ccctgacagc acaaaaattg ttccgacaaa 242341 gaagagcgag agacgccaga ccgttgtttt tatcgctttt ggtatcgtct tgtcaggatc 242401 aacgctttca ccggctgcga ttccgattag ttccgttccc gaaaaggcaa aattgacgga 242461 cagcatcgtc atcaaaatcg ggacaaatcc attgggaaaa agcccgcctt ccgccgtgaa 242521 gttggacagc atcggagcgg cttctccgcc tttgatcggg atgatgccga acatggcaga 242581 gccgcctaaa agaataaata atacaatggc taatactttg atgctggaaa accaaaattc 242641 tgattcagcg aaaaacttga ccgaaaatgc gttaagcaag aagatgaaca gcgcaaagac 242701 ggcactccac atccaaaccg atgtatgggg gaaccagcgc tgcattaaca ggccggctgc 242761 tgtgaattct gatcccaatg ccacggtcca tgtcagccaa tacagccaag cgaccgtaaa 242821 tccggtgccc ggccctatgt atttggctgc ataggtgtga aaggcgccgg tcacaggcat 242881 ggcgactgac agctcaccga ggcatagcat gaccagatag acgatgccgg ccccgactaa 242941 gtaggcgagt atcgttccgg ccgggcctgc ttgctgaatg gtataacctg agcttaaaaa 243001 cagcccggtt ccgatgacac ctcccaagga aagcataaag aggtgccggc ttttcatact 243061 tctctgaaag gttgtctcat tcttgttgtg ggcagagttc atctttttcc aactttctat 243121 cagcgattta tttccttcct aataaaaaat ctcatgtcag aaagtgacac gagactccgg 243181 cgaaccggct ttaagttaga atatacaaac tattccgata agtcaagttg tttttaaaga 243241 gcgggcccaa gccgcaattt cttgaatatt ttcgggtttt gtccggcagc agccgccaat 243301 cagcctcgct cctttttcat gccaggtgcg ggcgctcgcc ccgtaagatt ctgcgcatgc 243361 tgcgccgttc cacgtttttg tttccggatc atattgctca cctgaattcg ggtagacaat 243421 gatcggtttt gacgtgttct tttttaactc ctctatcaag gaagggatat gctgaagcgg 243481 cgtgcagttg atgccgagtg ctgcaatttg gcggtgttca tcaagccacg atgcgcagtc 243541 agctgcaggt gttccgtcac tgatatgcaa gccgtcttta gcactgaagc tgatccatgc 243601 atacgtttca ggaaattcct tcaacagccg aacaatcgct ttggcttcag tcagacacgg 243661 aatcgtttcg catgccaata catcagctcc ggcttcaatc agcgccttca tccgggggcg 243721 atgaaattca atcagttcat cttctgatat tgcgtagttg ccgcgatact cagacccgtc 243781 tgcaagataa gcgccataag ggcctataga agccgcaatg atcggttttg gccgattcaa 243841 acggttctct tcaagcgacc aaaattcatc acgtgcttca gctgcgatgc tgacggacaa 243901 ctcgatgagc cggcgtgctt ccgcttcgct cagcccgcgt gcggcaaagc cttcaaatgt 243961 agactgatag ctggcggtga ttgcacaatc ggcgcctgcc gcaaaataat cagtatgaac 244021 ttgtttaatc agctccggct cttccatcag gatttttgcc gaccacagac tgtcattcaa 244081 attacagccc ttgcgttcaa gctcggtcgc catggcgccg tctagcacaa taagcgggta 244141 tgtatctaat atgtgttgga taggattcat agaatgtacc gatgccttct ttcagatttt 244201 tttgaaaaag atatgaaaat cgtaatggag gcttacgtgt ttgtcaataa acgcaaaaag 244261 agaaaggtgt tcagcccata tgtctgaaca cccttttctt atgatatttg tttgttgtgc 244321 gtgtcagtct ttgtgtctga aaccggccag cactcaatgc cattatggtt tttgagcaca 244381 tctttataaa agaccggatc cttgcctgct tttttctggc gtgtatagtc tttcagcgcc 244441 gtaaaaacga cctttgatag taagaaaatc gcgattaaat tcacgatgac catcaaaccc 244501 atgaacaaat cagcaagatc ccagacgagc tggactttgg caacacagcc aaacacgatc 244561 attgccagca cgccgatacg gtagacaaaa atcagttttt tgcttttgtt caaaaagccg 244621 atattggttt cgccataata atagtttcca attagagcac agaatccgaa taacaaaatc 244681 agaatcgcga gaaagcctga tgcccatgat ccgacatggg agctgaggga ggcttgtgtc 244741 aaggcgattc cgctcagacc cggagtatga taggcatccg aaaacagaat gataaaagcg 244801 gtgcttgtac aaatgaccag tgtatctgtc agtacaccaa aagcttggat cagcccctgt 244861 ttgacgggat ggcttgttgt ggcggtggca gcggcatttg gtgcgcttcc cattcccgct 244921 tcgtttgaaa agattccccg tctgacgcct tgcatgagtg ccgcgcccaa agccccgccg 244981 gcggcctggt caaaaccaaa cgcatttttc acgattagcg caagcacacc tggcagctgc 245041 gtaatgttgg agaaaatgac gaaaaacgca actccgatat acaggacagc caatacgacg 245101 acaatggatt cagccagctt tgcaatgcgc ttgactccgc caaaaataat cgtgccgaat 245161 acagcaatta aaatgagtcc caatgtcagg cggtttgtgc caaacgcgtt ttcaaaggca 245221 aggctgactg tattggattg aaccgagttg aagacgatac cgaacgataa ggtgattaac 245281 acagcgaaca gcgcgcccat ccaccttttg ttcagccctt tttccatgta atacgccggc 245341 ccgccgcgga agccgtttac atcttttact ttataaatct gagccagtgt gctttccaca 245401 aagctggatg ctgatccgat aatggcgata atccacatcc agaagattgc accgggcccg 245461 ccgagtgcaa tggcgatagc aatgcccgta atatttcccg ttccgacacg ggccgccatg 245521 ctgatgcaaa aggcttgaaa cggagaaatg ctgttttttg accgggaagc agcaccttct 245581 cttaataccc tgaccatttc tttcagcatg cgaacctgta aaaacttaag cctgaacgta 245641 aaatagattc caaaagaaag gagcaaaaca attaatagct ttgaccacaa aagatcattt 245701 gcaataccga cgatatgttc taggatttgc tgcatagaat cacctctttt ttcatgttta 245761 aaaaatgctg agctcccatt cctgcgccat atgcttcagc agcataccgc cagtgaggct 245821 gttgccgtat tcatcaatgg caggcccgta aatgccgatg ccgcatccgg attgaaaagg 245881 ctgttctctt ctggcgcttg gaggcaccag cgccatgatg ccgccggaga cgccgctttt 245941 ggccggcacg ccgacaaacg ccgcatattt gcctgaagcg ttgtacatgc cgcacgtcag 246001 cattaatgcc ttggccaatt ttgccacatc ttttggaatc acctgctcgt gtcgaatcgg 246061 atgatacccg tcatgagcaa ggatcaggcc gatcaacgca atatcttctg tagtgctctc 246121 catagcgcat tgcttcaagt acacctcaag tgtttcttct acttcagctt ctaaaaagtt 246181 tgtttctttt aaatagtagg ccagcgctct gttgcggtgg gcggtttccc attcagaacg 246241 gaatacttct tcatgaattc ttggccgttt tcctatcaaa gtttccatca ccgagtaaag 246301 aaactcgagc ttttcgtatg cagattctcc gggaaggatc gaagcgatgg tgagggcacc 246361 cgcgttgatc atgggattga agggctttcc cggcttgttg atttcgagcc gaatgattga 246421 attaaaggcg tcacctgtcg gctcgacatc tacgcggtca agcacatagg gaatgccgcg 246481 gctcatgcag gcggcaataa agctaatcac ttttgaaatg ctttgcatgg taaaagagac 246541 gttccagtcg ccggcgtgta tcatcgttcc atcaggctcc aatacacaga tgccgagctg 246601 tgaatcattg acttttccta aagcggggat atagtttgcg ctttgtccat tggcggcaaa 246661 agggcgatag tattcaaccc aatcatgaag ctgtaacgcc gggtttatgt ctttctggtg 246721 ctcttttatc aattctttca tcgaattcct cctcactgat ttttttctta aaggactgag 246781 gtgtatcaaa acgaaggcta agggggcgtt aaacgctttc ataatagcgg aaggtataat 246841 tactgtataa tggagactac agaatcatac aaaatacgac aaaaacattt tgaaaataag 246901 cagtaagatt tataaaaacc tcatgttctg ggtcaaaagc aatttgcagg ttttctcccg 246961 attccccaaa ataaaaagcg aggatgtgat caacataaaa ctggaacggt ttattgaaaa 247021 agacggatat atactggccc tcatgctgat tacggtgccg ctggccggtg aactgaaatt 247081 ttatcccctc aatgaagaat tccgggtcag ctttggggca ccggtttttt tcttcttttt 247141 atcattgttg cggcatgtgc ccgctgtgct gccgggtttt ctgactggag cggctgtttt 247201 catctttcgc gtctttctgg aattatgggg cggaggacac aatgggctga ctccgattct 247261 gtatgatcaa gcgtctggct ttttctttta tatgacttac gcctgtctgt tttccatatt 247321 aaaggccaat cgtttccgtg aacggccgat tatgctcggt ttcattgggt ttatgattga 247381 agttgtgtca gattgtgtcg agctaactgt gcaatttctc atttttcata cggttgtcac 247441 gcctgagaaa atcactgaca ttgcggtgat tgcgatttct cacacattta ttgtgatgag 247501 cttttatagt gtgctgaagc tgtatgaaac acaatcgaga gaaaaacaga caaggcagca 247561 gcacgagcac atgctgatga tcgtttccaa tttatatgaa gaaacggtgc acctaaaaaa 247621 gacattgaaa acgacagaga aagtgacaaa cgattcgtat cagctctatc gggaaatgaa 247681 gggcaaggat gttcagctga gcggcagaat cctgagactg gccggagaga ttcatgaagt 247741 gaaaaaggac aaccagcgga tattcgcagg gctttcaaaa ctgatttcga atgagagttt 247801 gagagattat atgagggctt ctgatttgct gcagctcgtg attcgaatga atgaaaagta 247861 cgctgaagca ctagggaagc agattgattt ttactgctcg atcgagggag agcatgacga 247921 atatcacgta tttatcgtgc tttcgatcat taataatcta acagcaaatg cggtagaggc 247981 tatggatgaa gagggaatgg tcagcctgag gctccgtaag ccaaatgaga gtatggtaga 248041 attccaggtg gaagacaatg gccccgggat ttccgagaaa atcggagaca ttgtgtttga 248101 cccgggcttt acttcaaaat atgacgaatt tggcacgcct tctacgggta tcggactttc 248161 ctacgtaaag gaaatcgtga cagagctaga aggggatatc acgtttgata atcagcagcg 248221 gggagtggtg tttgccatca ggctgcctgt ccggcatttg attcagaaag ggtgaaccaa 248281 aagctatgcg tttttttatt gcagatgatg accgtgcggt gcggtcaatt ttaaggcaga 248341 tcattgagga cgaagatctc ggggaagctg ctggtgaagc agacgacgga agccaagtgg 248401 aagggcatat gctgcaattt aagcagattg atattttatt aatcgatctg ttaatgcccg 248461 gaagagacgg cattgagacg attcgtcaga tccagaatac gtactccggc aaaatcgtaa 248521 tgatctctca agtggaggcg aaggaaatgg tcggggaagc gtactcgctc ggcatcgaat 248581 attttatcca taagccgatt aaccgcattg aaattgtcac ggttctccaa aaggtgaagg 248641 agcggatcga gcttgaacac tcgattggag ccattcagca ttctctaagc cggcttgtca 248701 atcggactga acggaaagcg cgtccccagc agaagagtga cagcggttta aaagaggcag 248761 gaacattcct gttgtccgag ctgggcatga tgggagaagg cggcgcacat gatctcatgg 248821 cggtcctgca gtatttagca gaacacgagc aatccgagcc gcacgaaaaa caaagccctt 248881 cgctaaaaca aatattcacc caagtagcgg tacggaagct ggggacagga gcctcacaga 248941 cggaagtcaa tcgcgaaatg aaagcctcgg agcagcgtat ccgcagagcg attattcatt 249001 cgctgcacca ttttgcttca ctgggcacaa ctgatttttc gaatccaaaa tttgaaacct 249061 atgcatcgaa attctttgat tttccggttg tcagccagaa aatgaaagaa ctccaatcca 249121 aggatgcaaa accccttgca cctgctagaa taaatatgaa aaaattcatc cacgtgtttt 249181 ttttggaagc aaagcttttg catgagacga tgaaacaaag aaggatataa accaaacagc 249241 cggctgacca ggctgttttt ttgctgcgca gaatcccggc cggacagtga tttaccgctt 249301 ttttataaaa tatcagaaaa taaagatatt gacttattgt ttatttgtct tacaattaaa 249361 caaaaggata tatgggaagg agcggatgtg aaagaaaaat taataaaagc gcttacagat 249421 agaggccgta tacacaaata acaggaggtt atgttgatga gccgtatcag aaaagcaccc 249481 gctggaattt taggttttcc ggttgctcct tttaacacac aaggaaaact ggaggaagaa 249541 gctctttttc aaaacattga gtttttgctg aatgagggct tggaagcgat atttatcgct 249601 tgcgggtctg gtgaattcca atctctcagc cagaaggaat atgagcaaat ggtggaagtc 249661 gcagtctcgg cagccggagg aaaggtgccg gtctacacgg gggtgggcgg caacctcagc 249721 acagcgcttg attgggcgca gctgtcggag aaaaaaggcg ccgacggcta cttgattctg 249781 cctccgtatt tggtgcatgg cgaacaggag gggctgtacc agtatgcgaa aacgattatt 249841 gaaagcactg acttgaacgc gattctttat cagcgcgata acgcagttct ctctgttgaa 249901 cagatcaaac gtctgaccga atgtgaacag cttgtcggtg tcaaagacgg ggtaggaaat 249961 atggatttga atatcaatct cgtctatacg atcggcgacc gcttgggatg gctcaacgga 250021 atgccgatgg ctgaagtgac gatgccggct tatctgccga tcgggttcca ctcttactct 250081 tcagcgattt caaattatat cccgcatatt tcgcgaatgt tctatgatgc attgaaaaac 250141 ggaaatgacg agcttgtgaa ggaactctat cggcatgtga ttctgccgat caacgacatt 250201 cgcaaacaac gaaaaggcta cgccgtatcc ttgattaaag ccggtatgga aatcatgggt 250261 ttgaatgtaa ggaatacagc cagaccgcct gtcggcccgg ttgaaaaaga tcattatcag 250321 caattggaag caattttgaa gcaggcggct gaccgttttc cgaaaaaagc cgcgacggtt 250381 tgaccagaaa aaacacgaaa ggggcaatgg gcatgtctgt gatcacggaa caaaacacgt 250441 acctcaactt tattaacgga gagtgggtta agtctcaatc aggcgatatg gtcaaagtcg 250501 aaaaccctgc cgatgtgaat gatattgtcg gatatgtaca gaattcaacg gctgaagatg 250561 tggaacgtgc cgtcaccgcc gccaatgaag ccaaaacggc ttggagaaag ctgacgggtg 250621 ccgagcgcgg ccaatactta tacaaaacag cggatatcat ggagcagcgc ttggaggaaa 250681 tcgccgcctg tgcaacgcgt gaaatgggta aaacattgcc ggaagcgaag ggagaaacag 250741 cccgggggat tgccattctg cgctattacg ccggagaggg catgcgaaaa acgggtgacg 250801 tcattccgtc tactgacaaa gacgcgctca tgtttaccac ccgtgttccg ctcggtgtgg 250861 tcggtgtgat ttctccgtgg aacttcccag tggcgattcc gatttggaaa atggcgccgg 250921 cattggtata cggcaatacc gttgtcatca aaccggcgac agaaacagct gtgacatgcg 250981 cgaagatcat tgcctgcttt gaggaagcgg ggctcccggc aggggtcatc aatttggtga 251041 caggcccggg ttctgttgtc gggcaggggc ttgctgagca tgacggtgta aacgccgtta 251101 cgtttaccgg ttcaaatcaa gtcggaaaaa tcatcgggca agccgcttta gcgaggggag 251161 ccaaatatca gcttgagatg ggcggcaaaa accctgtcat cgtagctgat gacgctgacc 251221 ttgaagctgc ggcagaagct gtcataacgg gggccttccg ttcaaccggc cagaaatgca 251281 ccgcgacaag ccgtgtcatc gtacaaagcg gaatttacga gcgctttaaa gaaaaactgc 251341 tccagcgcac aaaagatatt acaatcggag acagcttaaa agaggatgtc tggatgggac 251401 cgatagccag caagaatcag cttgataact gcctgtcata cattgagaaa ggcaaacagg 251461 agggcgcttc ccttttaata ggaggagaaa agctggagaa cggaaagtat caaaacggct 251521 attatgttca gcctgccatc tttgacaatg tgacatctga gatgacaatt gcccaggagg 251581 aaattttcgg tccggtgatc gccttgatca aggtggactc gatagaggag gcgctgaaca 251641 tcgccaatga tgtgaagttc ggtttaagtg catccatctt cacggaaaac atcggccgaa 251701 tgctttcttt cattgatgaa atcgatgccg ggctggttcg gatcaatgca gaaagcgcag 251761 gtgttgagct gcaggcgcct tttggcggca tgaagcagtc gagctcccac tcccgagaac 251821 agggtgaggc agcgaaggac tttttcacag cgatcaaaac tgtttttgtg aagccgtaat 251881 ggtgctggaa agaggcgtgc gtctctttcc cggtttatca caaccagcat atgattctct 251941 actttgaaaa ggagaagata ctatgaaaaa agactttgcg agtgttactc cggcgggcaa 252001 aaaaacgtcc gtgcgctggt tcatcgtgtt tatgctgttt cttgtgacct ctattaacta 252061 cgcggatcga gcgacgcttt ccatcaccgg agattccgtc cagcacgatt tgggattgga 252121 ctcggtcgcc atgggatatg tcttttctgc ctttggctgg gcctatgtca tcggacagct 252181 tccgggcggc tggctgctgg accgttttgg ttcaaagact atcattgcgt taagcatctt 252241 tttctggtcg ttttttacgt tgctgcaagg ggcgattggc tttttctccg ccggcacagc 252301 gattatcctg ctgtttgcac tgcgttttct ggttggttta tcagaagcgc cttcatttcc 252361 cggaaacggc agagttgttg cctcatggtt tccaagctcc gagcgcggga cagcttcagc 252421 cttttttaat tcagcacaat acttcgcaat cgtcattttt tctcctttaa tgggctggct 252481 tacccactct ttcggctggc attccgtttt cgttgtcatg ggtattgcag gcattcttct 252541 ggctgtcatc tggctaaaaa cggtgtatga accgaaaaaa catccgaagg ttaatgaagc 252601 tgagcttgcg tacatcgaac agggcggcgg gctgatttcc atggatgaca gtaaaagcaa 252661 acaagaaaca gaatcgaaat ggccgtatat caaacagctg ttaacgaacc gcatgctgat 252721 tggcgtgtac atcgcgcaat actgtattac gactctcacc tatttctttc tcacatggtt 252781 tccggtatat ttggttcagg cccgcggcat gtctattctt gaagctgggt ttgtcgcttc 252841 cctgccggcg ctgtgcggat ttgccggcgg cgtgcttggg ggcattgtgt cagacatctt 252901 actcaaaaaa ggccgttcac tgacctttgc aagaaaagtg ccaatcattg ccggcatgct 252961 gctgtcttgc agtatgattg tctgtaacta cacagattca gcatggctcg tcgttgtcat 253021 tatgtcgctc gcgtttttcg gaaaaggctt cggcgcattg ggttgggctg tcgtgtcgga 253081 cacgtctccg aaagaatgtg caggattaag cggcggtttg ttcaacactt tcgggaatat 253141 tgcctcaatt acaacaccga ttattatcgg atacattgtc aatgccactg gatctttcaa 253201 tggcgcgctt gtgtttgtcg gcgctaacgc gattgcggcg atcctcagct atttgctgct 253261 ggtcgggccg atcaaacggg tcgtgttaaa gaaacaagaa caagaccccg atcaatcgtt 253321 gcctgtctaa tatttatgaa agcgctttat aaagggagga aaatgcatga gttcaccgat 253381 acaagagcag gttcaaaaag aaaaaagatc gaatattccc tcaatttctg aaatgaaggt 253441 gattcctgtt gcgggacatg acagcatgct gctgaatcta agcggagcac acagcccgtt 253501 ttttacccgg aatatcgtaa tcttaacaga cagcagcgga aatcagggag tcggcgaggt 253561 gcctggcgga gagcatattc gccgcacact ggagctgtca gagccgcttg ttgtcggaaa 253621 atctatcggt gcgtaccagg cgatattgca aacggtcaga aagcagtttg gcgatcagga 253681 caggggaggg cgaggaaacc agacgtttga tttgcgcacc actgtgcacg ccgtcaccgc 253741 actggaagcg gctttgttgg atttgcttgg aaagtttctt caggaaccgg tcgcggcttt 253801 gctgggcgaa gggaagcagc gtgatgaagt aaaaatgctc ggttacctct tttacatcgg 253861 cgaccgaaat cggacgacct tgccgtatca aagcgatgag cagtcagatt gtgcgtggtt 253921 ccgtctgcgc catgaggaag cgctgacgcc ggaggccatt gtgcgtcttg ccgaatccgc 253981 acaggagcgc tatggctttc aggatttcaa attgaaaggc ggggtgctgc ggggagaaga 254041 ggaaatcgaa gctgttaccg cattatcgaa acgttttcca gaggcaagga tcactcttga 254101 tccgaacggg gcatggtcat tagaggaagc tattgcatta tgcaaaggaa agcaagatgt 254161 gctcgcgtat gcggaagatc catgcgggga tgagaatggc tactccgctc gtgaagtaat 254221 ggctgaattc cgccgcgcga cagggcttcc gactgcgaca aatatgattg cgactgactg 254281 gcgggaaatg ggtcacgcga ttcagctcca cgcggtcgat ataccgctgg ctgatccgca 254341 tttttggacg atgcaagggt cggtgcgggt tgcgcaaatg tgccatgatt ggggtttgac 254401 atggggctcg cactccaaca accactttga tatttccctt gcgatgttta cccatgtggc 254461 agcagcggct ccggggcgga tcacggcgat tgatacccat tggatctggc aggacgggca 254521 gcgattaacg aaacagcctt ttgagatttc ttctggctgt gtcaaggtgc cggataagcc 254581 tggactaggc gtcgatattg atatggaaca agtggaaaaa gcgcatgaga tctatcggaa 254641 aatgaattta ggcgcacgga atgatgcgat cccaatgcag ttcctgatca gcaactggga 254701 atttgaccgg aagcgcccgt gtcttgtgcg ataagtttga ttgtaaatat tgtcatatcc 254761 gctattttgt cttacaattg aacaactgaa gggagagttg ttcgtgtacg aaggtttaga 254821 ggatttgaaa gtcgatacag tcaatcggaa aacattagcc aagcaggtca tcgaacggat 254881 tgtccattta ttatcgagcg gacagttgag ggccggagac aaattgccga cagaaatgga 254941 actgatggac attttgcatg tcagcaggcc ggtgctacgg gaagcactca gttcacttga 255001 aacgctgggc gtcattacga gaaaaacacg agggggcaca tatttcaacg ataaaatcgg 255061 catgcagcca ttttccgtca tgcttgcttt ggccactgat aatcttccgg ctatcattga 255121 agcgcggatg gcgctagaac tcgggctcgt gacaattgcc gcggaaaaaa tcaatgagga 255181 agagcttcag cgtttgcaga agacgatcga cgatattgcc aacagcactg acaatcatta 255241 tggtgaagcg gataaagagt tccatcgaat tattgcgtta agcgccaata accccgtcgt 255301 tgaagggatg attcagtccc tgctgatcac ccatgcgaaa attgacagcc aaattccgta 255361 cagggagaga gatgtaacgg tcgaatatca caaaaaaatc tacgacgccc ttgccaaaag 255421 agatccgtac aaagcacatt accacatgta tgagcatctg aaatttgtcc gtgacaaaat 255481 tctaaaagga atggatgaaa aataatggtg agcaaccgca gttgaaacgt aagagctgcg 255541 gtttttttaa accaatttag aaaacgctta ctaaaatatg aggagtgatt ttcatatggc 255601 gatgaacctc aggaagaacc aagcccccct ttacatcaaa gtgcatgaaa tagataacac 255661 cgcgattatt gtaaatgatg gagggctgcc aaagggcact gttttctcat gcgggctcgt 255721 acttgaagag gatgttcctc aaggccataa ggtggccctc accgatctca atcaagggga 255781 cgagatcgtg cgttacggag aggtgatcgg atttgctgat gagacgatca aacgcgggag 255841 ctggatacgg gaagccctcg tgagaatgcc cgctcctccg gcgttagacg atcttcctct 255901 cgcaaacagg gtgccgcagc cgcggccccc acttgaagga tatacatttg aaggataccg 255961 aaatgcggat ggcagtgcgg ggacaaaaaa tatcctcggc atcacgacaa gtgttcaatg 256021 tgttgttggc gttttggatt atgcagtcaa acgaataaaa gaagagctgc tgccgaaata 256081 cccaaatgtc gatgacgttg tgccgctgca tcatcaatac ggatgcggcg tggcgatcaa 256141 tgcgcccgac gctgtcattc cgatccgcac gattcaaaat cttgcgaagc atccgaactt 256201 cggcggtgaa gtaatggtaa tcggattggg atgtgaaaag ctcctcccgg aaagaattgc 256261 ctccgaaaat gatgatgaca ttctatcgct ccaggatcac cgaggttttg cggcgatgat 256321 ccaatccatt ttggaaatgg cggaggaacg gttaatcagg ctgaacagca gaacccgggt 256381 gtcatgccct gtttcggatc tggttatcgg cctgcaatgc ggcggcagtg atgcgttttc 256441 cggcgtgacg gcgaaccctg ccgtggggta tgcggctgat ttattggttc gcgcaggtgc 256501 aacggttttg ttttctgaag tgacagaggt gcgggatgcc attcatttat taacgccgcg 256561 ggctgtcagt gaagaggtcg gacaatcgct gatcaaagag atgaagtggt atgacagcta 256621 tcttcggcgg ggagacgcag accgtagcgc aaacccgtca ccaggcaata aaaaaggcgg 256681 attatccaat gtggtggaaa aagcgttagg ttcggtagcg aaatcaggca caagccccat 256741 ctccggcgtg ctcggccctg gtgaaagagc aaagcaaaaa ggcctgctgt tcgcggcgac 256801 accggcaagc gattttgtgt gcggcaccct gcagctggct gcgggcatga atttgcaggt 256861 gtttacgaca gggagaggaa caccatatgg cctggctgct gcgccggttc tgaaagtatc 256921 gacgcggcat tccttatcag agcattgggc tgatttaatc gatatcaatg ccggccgaat 256981 cgcgacagga gaggccagta tcgaagacgt aggctgggaa atcttcagga cgattttgga 257041 tgtggcaagc ggccgcaaac aaacgtgggc agaccgttgg ggtcttcata atgatttgtg 257101 cttgtttaat cctgctccag tgacttgatt catgttttta tagcggaaag atggaatatg 257161 ctgtaaaatg aaaatcagcg tataggaaac ggaggggtta cagcatggca ttcattagat 257221 tccgagtgac acgaattcaa tagtgaacaa ctctcgcctg aatgcgagag aatcgggatg 257281 aatccgccta tgtatgagcc cttatatggt tatcaaaaaa gagggtggcg tgcctgccct 257341 tttttgtgcc ttcaagcatc ccttctctct actgcaggcc ggagcatgag aaaggggaaa 257401 tgggatgaca aaccttaacg aaaaacagct tatcactgag attgtcgggc ttgcacgcag 257461 ccaaggtttg acggttcatt ctgagaacgc gcaattgaat gaaaccggaa tggactttca 257521 agttgtattt gccaaggacg acacaggtat gccatgggtg ctgcgaaaac cgcggcgaag 257581 tgatgttgtg gaaagagcat ctgcagaagg cataacgctt gcctttctcc gcgcgaatct 257641 gactgctgat gtgccggatt ggagaattca tacaccggaa ttgatcgctt accccatgtt 257701 aaaaggaacg ccggctgctg gaattgactt ggaacaaaag caatatgtat ggaatatgga 257761 tcatcagccg ccgtcagacg actttgtccg cacacttgcc gacatactgg ctgaattaca 257821 tggcacggat caaatatctg ctgggcaatc cggaatagaa gtgataaggc cagaagattt 257881 caggcaaatg acagcagact ctatggttga tgtgaagaat aagcttggcg tatctacgac 257941 gctttgggaa agatggcaaa agtgggtaga tgatgatgca tactggccgg gtttctcttc 258001 tttgatacac ggcgatctcc acccgccgca tatccttatc gatcaaaatg gacgtgtcac 258061 aggacttctg gattggacag aagcgaaggt tgctgaccca gccaaggatt ttgttcttta 258121 tcaaaccatt ttcggagaaa aagaaactgc ccgtttgctt gaatactatg atcaagcagg 258181 cggccgaata tgggcaaaaa tgcaggaaca catctcagag atgcaggcgg cgtatccggt 258241 ggaaatcgcc aagctagctc tgcaaacaca gcaggaggaa cacatcaata tggcgctgga 258301 agcacttggt gtaacatcgg attaagaatt gacttcgttt catgaaccga gtattataaa 258361 ctctacaaat aatagaacgg attaacaatc gtgaggaaga gcaagtacgc atcagaatgg 258421 aggttcagag agtcggtggc aggtgtgaac cgatcctccc ctgatgccga atgggcttct 258481 gaattgcttt gctgaacgga tagtaggcga tgccgggttt ctctccccgt taccaagaga 258541 ggagtatcga aacataggtt ttctgtactt agagtgaacg gctgtatagc tgttaataaa 258601 ggtggtaccg cgagaccctc gtcctttgca taggacgggg gttttttgtg tttcttaaag 258661 gaggtgacgg ccaatgtacg atggctggtg gtggcatagc agatgagtta gaaaggagga 258721 tatcaaatgg tcattgcaac tgatgatctt gaggtcgcat gtcctaaatg tgaaagagcg 258781 ggagaaatcg aaggaacacc ttgcccggcc tgcagcggaa aaggtgttat tctgactgct 258841 caaggatata cgcttctcga ttttatccaa aagcatttga ataagtaaag gagaaaagct 258901 gagctgagat gagagcagaa gagcagagta agattcgtga ggccgcagca ggtacgattt 258961 ttttgctgat cggaacagtt tgttttgcgt ctaaatcgat ttggataaaa tgggcatacc 259021 aaatgggtgc tgagccagat gccgtgctgc tatacaggca gctgctggct gttccgctgt 259081 tttggctgat ttttttaata taccgtcctc caatgccaga cggtaagaaa aaaggagacc 259141 tatggaaggc ttgtggcgcg ggagtgtttt gtttttttct gtctcccttg cttgatttta 259201 tcgggctgaa ccatgtatcc gcaatggttg aacgtatatt gctgatgagc tatccgttgt 259261 ttgtgtttgg attcaccgcg tgtcgtgacc ggaaaatgtc ctcaattcag gaccttttcg 259321 cagttctggc ggtcatgttt gggcttttct tggcgctggg cggctggaat gctgagcttt 259381 tccaggcgaa tatgattgga gctgtattca ttttgttatc ttcggccgtc tatgctggtt 259441 atcttgtcct ttccgggcat ctcgtccatc aaatcggagg gatccgtctc aatgcatacg 259501 ggatgacagc tgctggagct gccatgatgc tttacacagg gataaaatcg gcggctggca 259561 tgaatacgcc aatggcagca tatccgcttt ctatgtatgg tttgttcgca gtaattgcag 259621 tcgttaccac agtgattcca tttgtgctaa tgcttgaggg cataaaacga atcggggcac 259681 agcgagccgc cgccatttca atggcagggc ctatcctgac gattttctat ggagctttat 259741 ttctcggtga acggctcggg ctcattcaag tcattggatg cggtggcgta ttttttgtca 259801 ttacgggcat ggaatacagg aagctgaaaa caggaaaaaa agaataattt ttataaaaca 259861 cacacgtttt tcaattacaa taagtgtaat tacgtgtgtg ttttttgatt ttgtaaaggt 259921 taggtgagga gatgcagcgc atattgcttg tagaagacga ccactcaatc agtgaaatgg 259981 tggatcatta tttaacaaaa gaaggctttg gaattgtgca tgctttcgac ggagaagagg 260041 gcatccggct gtttcagcag ggttcatacg atttggtcct ccttgatatc atgctcccga 260101 agctgaacgg catggatttt ctgaaaatca tccgggaaaa aagcaatata ccggtcttaa 260161 tgatttcggc aaaagatgga gatgtggaca aggcattggg actgggcttt ggggcggatg 260221 attatatcgc caaaccgttt tcgatgattg agctgacagc ccgagtaaaa gccgcgatac 260281 ggcgggcgac gcaatattcg gcagaggagc cggctgtgaa taaggtgatc cggattcacc 260341 agcttgcgat agatatagac aatgtttccg ttttgaaaaa cggagagccg ctccagctga 260401 cgtcaacaga atggcagctg ctgtgcttat ttgcatcaaa tcctaaaaaa gtgtttacga 260461 aagaacaaat ctaccgttcc gtttggaatg aagagtactt tgatgatcag aacatcatta 260521 acgtacatat gcggcggctc agagaaaaga ttgaggatga cccctcctcc cctcaatata 260581 ttaaaacgtt atggggcatc ggttataaat taggagagtt ttagaatgac agtgctatgg 260641 gtggccgctg tcatcgctct ggcgtgtctg aatgtgattc aattcataat gaaaaagaag 260701 cgggacggga atctggctta cacggctgac cagcttagct acatgctcag ccgggattcg 260761 gcaggacaaa ttttgcttcc tacagacgat catgcgctca aagacttgct tgttaacatc 260821 aatcttatcg ttgagaatcg tcagcagatc agcgcccaat ttgccaaaac agagcaatcc 260881 atgaagcgga tgctgaccaa tatgtcgcac gacctgaaaa cgccgttaac ggtcattctc 260941 ggttatattg aagccattca aagtgacccg aacatgccgg acgaagagcg ggaaagattg 261001 ctggggaagc tccgccagaa aacaaatgaa cttattcaga tgatcaattc cttttttgat 261061 ttagcgaaat tagaatctga agataaagag atcccgatca ccaaagtaca tatgaacgac 261121 atatgcaaac gaaatatcct gcactattat gacgctgttc agtcaaaagg ctttcaagca 261181 gccatcgata tccccgatac gccggtgtat gcgcaggcga atgaagaggc tctggacaga 261241 atcctgcaaa acctattgtc caatgcgatt caatatggcg cggccggcaa gttaatcggg 261301 ctgacgctgt cttatgatga gaggaacatc gccatcaccg tatgggatcg cggaaaaggg 261361 attagtgaaa ccgatcagca gcgggtgttt gagaggctgt acacactgga agaatccaga 261421 aataaagcat ttcaaggaag cggcttgggt ttaaccatca caaaacggct tacagaaaaa 261481 atgggaggca tcatatccgt ccaaagcaag ccgtacgaac ggactgcatt tacgatcaca 261541 ttgaaacgca tgacatatta atcgtaagaa tttcttaagg tttgagaaat aaaaatgaca 261601 gggctcgccg ctacaataga aaacaggaaa agagagggaa ggagaaacaa agttgactta 261661 tatcgtacaa acaaacgggc tgaccaaaac atatcagggc aaagaggtcg tatccaatgt 261721 cagcatgcat attaaaaaag gtgaaatcta tggctttctc ggcccgaacg gcgcggggaa 261781 aacaaccatt atgaaaatgc tgacgagcct tgtcaaaccg acaagcggtg aaatcatcat 261841 ccttgggaac aagttcaccc acacgtcata tgaggtgctg gggaacatcg gcagcatgat 261901 tgaatatccg attttttatg aaaacctgac agctgaagaa aatttagatc tgcattgtga 261961 atatatggga taccacaata aaaaagccat acaagaagtg ctggatatgg tgaatttaaa 262021 acaaatcgac aaaaaacccg tcaaaacctt ttccctcggg atgaagcagc gccttggaat 262081 tgcgcgtgcc atcctcacga agccggacct gcttattctg gatgagccgg tgaatggtct 262141 tgaccctctc ggcattaaaa agatcaggca attgtttcaa gtgctgagca aagagtacgg 262201 gatgacgctg ctgatctcaa gccacctgct gggtgaaatc gaacaaatcg cggacacaat 262261 cggcgtcatt cgggacggca ggctgcttga agaggtatca atggaggatg tcaggggcca 262321 gaacactgaa tacatcgagc ttgtcacgcc gaatcagaca agggcctgct ttgtgctgga 262381 gaaagagctg caattaacca actttaaaat attaaatgag aaaacgattc gaatttacga 262441 ggctgaagcc tctcaggctg ccatatccaa agcattgatt ttaaatgatg tagacattga 262501 atcaatgaac aaaaagtata cgtcgctgga ggattatttt atcaaattga tcaacggcaa 262561 tagcatcagt gcgtaaagga ggagagacac gttgatgaat ttgatcagaa tcgaattaag 262621 aaaaatgaaa atgggctggt atatcagagg tgccctcatt gccaacgtga tcattatggg 262681 ttttatgtgg ctgatcagtt attccgaaaa agccgatggc ggggtttcgt tccaaagtac 262741 ggatgaagca ttcctcatca tcggcacctt cgtcagagcg gtatttatcg tatttggcgc 262801 tgtgctgatc gtaaaattgg tgatttcgga atataaaaac aaaaccattc ttgtgatgtt 262861 cacgtacccg atcagccgta aaaagctgct caccgctaag ctcatgatcg cgggcggact 262921 gacgtttatc acgattttac tttcaaatat actcatagcc gccggtttct tttggctgaa 262981 ctcgatctgc catttcatac cgggagagct tacttccgag atcatttctc aacaggcggt 263041 caaaatggcg gttttcgctt ttggcgccgc tggaaccagt ttagttccca tcttttttgg 263101 gatgcgtaga cactcggttc cggcgaccat catttcatct gtagtaattg tgatgctcat 263161 cagctcaaca agtccgggct tctcgatttc atctgttgtg tatatcccgt tatcgttagc 263221 ggcattcggt ttgttctttt cctacatggc gatcaggaat gcggacaagc aggatgcgta 263281 aacaaaggcg cccaatatgt ataaaaggcc gatgctgtca gcaccggcct ttccattatg 263341 agtctgttct tgtttcaaga taatgcttct tgccaatctc tttgctcatc atatagaaat 263401 ggaagcaata ttcaccgatt gccatgacga tcgcgccgaa taaagccgcc aatgcaactt 263461 caccgccagt catccccata gaaagcggca tgcccatcag ccagatcacg agaaaggcca 263521 aaccaaaatc agccaaagtt gcaatcatat tattccattt cggcaataca taaagatcgc 263581 ccagcaaata agaaataacc cctaacacaa tcgtcattag cagcgtatca ccaaacgtga 263641 aaccaaagcc cagaccaagc accagataca acacaataat cgtcataata cctttaatag 263701 cgagcgcttt cacatgtgtc attacaattc ctccttttgt catttgattt gttatgtata 263761 attcctcaaa tgtaaaaagt taaaccttat ttcttttcgg aggcgggtgc aaatctgctg 263821 gggagaggtc aatgatgtga atccaggaat tgaggctgcg gcgcttcgac agcggaaacg 263881 tgaagcttgt actgcaccgg acgctgcttt gatgcccaac agcccattat gtttgctgtt 263941 tttagatgaa taaatttaaa aacttctcct gtccctccgt catcacttct gaagtaatga 264001 aatatgatga aaagagatca aggggaggtg acgtgatggc ggtcgtgaga gcaacgagtg 264061 cggatgtcga tttgatggca aggctgctca gagcggaagc ggaaggcgaa ggcaagcagg 264121 ggatgctgct tgtcggcaac gttggaatta atcggctgcg ggcgaattgc tcagatttta 264181 aaggcctccg caccatcagg cagatgattt atcagccaca cgcgtttgag gctgtgactc 264241 atggatattt ttatcaaagg gcgcgagata gcgagcgtgc ccttgcacgc cggtcgatta 264301 atggtgaaag gcgctggcct gcaaaattta gtttatggta cttcaggccg cagggggact 264361 gtccagccca gtggtataac cagccgtttg tggccagatt taagtcacac tgcttttatc 264421 agccgacggc ggagacgtgt gaaaatgtat ataacacatt ttagagacag gacaccgttc 264481 aaattgaacg gtgtttttct ttgaaaagat gcaatgcaaa atattcctgt gagataatca 264541 aagaaaaaag agctgacgga gatgacagaa tggcaacaat tgacctgcaa aagaaaagtg 264601 taaagatcgt actggagaaa aagcagttaa cgaaggtgac ggctcgtgtt ggactggttc 264661 ttgatattac gggatcgatg agaccgctct acaaaaacgg gacggttcaa aatgtggtgg 264721 agcggatttt ggcagtggct gatcagtttg atgataacgg tttgctggat gtatgggtgt 264781 atgataatga attttcccga ttaaagccag tttcagaaaa ggatttttcg ggctatgtcg 264841 atcgtgaaat tttaaataat gaccgcttgc ataaattcgg cagaaatgat gagccgccag 264901 tcatgaagga cgtgctgcgc aaatatgtta cggaggaacc gagctcgtat cctgctttca 264961 ttgtttttat caatgacggg ggctgtaaaa agtcaatcaa accgataatt gaagcttctt 265021 ctgataaacc ggtgttctgg cagtttgtcg gcatcggaaa cggaaacttt gattttctca 265081 ataaactgga tacgttagaa gggcgtgtca ttgataacac gaacttcctg catatcgaag 265141 agattgaccg catttctgat gatgagcttt atgatgctct gcttgctgaa tttccatttt 265201 ggctgaaaga agcgaaggaa aaagggattg taagagaaca agagcctcct gctgaaaagc 265261 cgaaaaagaa gggctttttc agcagattgt tttcgaaata actgataaag agcactgagt 265321 cattctgcga aatggctcgg tgtttttgtt tttttaagat catgtgaaga aaaataggcc 265381 gaatgggcgg cttgcaaacg acaggatatg cagaaaacgc gtcattcagc cagctttcgg 265441 catgtttcag cagcaggctt gtgagggaag acctgttttt aatgttcagc gcttacaatc 265501 agttcacact tcttcacagt cgtttaacaa tgatttccta taatggagac gatcaatgag 265561 gagagagggg atcttgaatg gcatacgaca gtcgttttga tgaatgggta cagaaactga 265621 aagaggaaag ctttcaaaac aatacgtttg accgccgcaa atttattcaa ggagcgggga 265681 agattgcagg actttctctt ggattaacga ttgcccagtc ggttggggcc tttgaagtaa 265741 atgctgcgcc taacttctca agctatccgt ttacattagg ggtagcgtca ggtgatccgc 265801 tttctgacag tgtcgtgctt tggacacgtc tggcaccaga tccgctgaat ggcgggggaa 265861 tgccgaagca agcagtgcct gtcaaatggg aggtcgcaaa ggatgagcat ttccgcaaaa 265921 tcgtaagaaa aggcactgaa atggctaaac caagtcttgc ccattccgtt catgtggaag 265981 cggacgggct tgagccaaac aaagtgtact attaccgttt caaaaccggc catgaactaa 266041 gccctgtcgg aaaaacaaaa acactgcctg cccctggcgc caatgtgccg caaatgacct 266101 ttgcatttgc ttcctgccag caatatgagc acggatatta tacggcctac aagcatatgg 266161 caaaggaaaa gcttgatctt gtcttccatc tcggtgatta catatatgaa tacggcccaa 266221 atgaatatgt atcaaaaaca ggcaatgtcc gcacgcacaa cagcgcggaa atcattacgc 266281 tgcaagacta tcggaaccgt cacgctcaat accgttctga cgccaatctt aaagctgcac 266341 atgcggcatt cccttgggtt gtaacttggg atgaccatga agttgaaaac aactatgcca 266401 ataaaatacc tgaaaaagga cagtcggttg aagcattcgt gctccgccgc gcggcagcat 266461 accaggcata ctatgaacat atgccgctcc gcatttcctc tttgccgaat ggcccagata 266521 tgcagctgta ccggcacttt acgtacggaa acctggcgtc cttcaatgtg cttgataccc 266581 gccagtacag ggacgaccaa gccaataacg acggcaataa gccgccttct gatgaatcgc 266641 gcaatccgaa tcggactctg cttggaaaag aacaggagca gtggctcttc aacaatttgg 266701 gcagctcgac agcccactgg aatgtgctgg cgcagcagat tttctttgcc aagtggaatt 266761 tcgggacaag cgcaagcccg atctacagca tggattcgtg ggacggctac ccggctcagc 266821 gcgaacgggt tatcaatttc attaaaagca aaaatctgaa taatgttgtc gtactgacag 266881 gtgatgtaca cgcaagctgg gcatcgaatt tgcatgtcga tttcgagaag acaagttcaa 266941 aaatattcgg agccgaattt gttggaacct cgatcacttc cggagggaac ggagcggata 267001 agcgagcgga tacggaccaa attttaaaag aaaatccgca catccagttc tttaacgact 267061 atcgcggata tgtccgctgt acagtgacgc ctcaccagtg gaaagccgat tatcgggtga 267121 tgccatttgt gaccgagccg ggcgcagcca tttccacgcg ggcttcattc gtttaccaga 267181 aagaccaaac cgggttgaga aaggtatcat ccacaacaat ccaaggcggg gtgaagcaat 267241 ccgatgaggt cgaagaggat cgtttctttt cgcacaacaa agcccacgaa aaacaaatga 267301 ttaagaagcg tgcaaaaatc acgaattaag gagtggaaat tatgttttca aacattggaa 267361 taccgggctt gattctcatc ttcgtcatcg ccctcattat ttttggccct tccaagctgc 267421 cggaaatcgg gcgtgccgcc ggacggacac tgctggaatt taaaagcgcc acaaaatcac 267481 ttgtgtctgg tgatgaaaaa gaagagaaat cagctgagct gacagcggta aagcaggaca 267541 aaaacgcggg ctgaatgctg atgaggcaga caccgggtct gcctcttttt ttatgaaagg 267601 gagggctttt ttgaatggat aaaaaagaaa cccatctgat cgggcattta gaagagcttc 267661 gccgccggat tatcgtcacc cttgcggcat tttttctatt tctcatcacg gcttttttgt 267721 tcgtacagga catttatgac tggctgatca gggatttgga tggaaagctg gctgtgctag 267781 gaccgagtga aatcctctgg gtgtatatga tgctttccgg catttgtgcc attgcggctt 267841 ctatccctgt tgccgcgtac cagctgtggc gtttcgttgc accggcgctg actaaaacgg 267901 agcgcaaggt gacgctcatg tacataccag gtttatttgc gttgtttttg gcgggcatct 267961 ccttcggata ctttgtcttg tttccgatcg tgctcagctt tttgactcat ttatcctccg 268021 gccactttga aacgatgttt acggctgacc gctactttag gtttatggtg aatttgagcc 268081 tgccgttcgg cttcttgttt gagatgccct tggtggtgat gtttttaaca aggctgggca 268141 tcttaaatcc ttacagactg gccaaagcga gaaagctttc ctattttctg ctgattgtcg 268201 tgtccatatt gattacaccg cctgatttta tttctgattt tctcgtgatg atcccgcttc 268261 ttgtcctgtt tgaagtgagt gtcaccctat cggcgtttgt ctacaaaaag aggatgaggg 268321 aagaaacagc ggcggccgct tagtgcagcg taccacccgg tgacttcaca tcctcatcat 268381 attgtgcggc cgtaacagcg gcgattctca atgcccggac aatcgtgtcc aggctgaggc 268441 tcggcgctgt tttgtcgatt gtttgctgcg gaatgtaagg aatatgaata aaaccgccgc 268501 gaatgtgtgg ggatgtccgg ctaatgtgat ccattaaccc gtagaacaaa tagttgcata 268561 caaaggtccc cgctgtgtag gaaaccgcag ctggaatgcc gtgttccttc atcttagcag 268621 tcattcgttt cacgggaagc cttgtccagt aagcggcggg cccatctgga gaaatctctt 268681 catcaatcgg ctgatgtcct tcgttatcgg ggattcgcgc atctgcaagg ttgattgcca 268741 ctcgttccgg tgtaatctgc atccgtcctc ctgcttggcc gacacaaatt acgatatctg 268801 gctgatgttt ttgaatggct tggcgcagag tgtccagagc ggatctaaag acggttggaa 268861 tttgttccgc tgtaataatg gcttcttctg tctcgaagcc attaagccgt ttcgccgctt 268921 cccatgatgg attgacggtt tctttgtcaa aagggtcaaa gcctgtgatc agcacttttt 268981 ttctcattct cccatctcct ttttctttta ttctattgtt tatttatggg tttttcatca 269041 aaataatgta aaggagtgaa tcataatgga gcatttgccg gagcagtatc gccagttatt 269101 cccaaccttg cagacgcata cgatgcttgc cagctgttct cagagcgcat tggcagagcc 269161 tgtatcaagg gcgatccagg attattatga tagcctgctg tataaaggga cgaactggaa 269221 agaagcgatt gaaaaaacag agtttgcgag aaacgagttt gcaaagctga tcggggctga 269281 accggatgaa gtggcgattg tgccgtcagt ttctgatgca ctggtttctg tagcatcgtc 269341 cttaactgca tttggaaaga agcacgttgt atatacagat atggattttc cggcggtgcc 269401 tcatgtttgg caggcacact ccgattatac cgtatccgtc attccatcaa tagacggcgt 269461 gctgccgctt gaacaatatg aaacgcatat ttcggatgaa acagtactga cgtgtgttcc 269521 tcacgttcat tatcgtgacg gctatgttca ggatataaaa gcgattgccg agatttctca 269581 gagaaagggc tctttattgt ttgtagatgc ttatcaatca gccgggcata ttcccattga 269641 tgtgaaggaa tggggcgtag atatgctggc agcaggcacc cggaagtatt tgctcggcat 269701 accgggtgtg gcgtttcttt atgtgagaaa ggagctggct gacgcactga agccgaaagc 269761 atcagcttgg ttcggaagag agagcggatt tgatggggct tatgcaaaag tcgcgcgccg 269821 ttttcaaacg ggcaccccag cttttatcag cgtatacgca gctgcagcgg ctttatcgct 269881 gctgaatcat attggggttt ctcatatcag ggatcatgtg aaaacgatct gtgccgatgc 269941 agttcaatat gccgctgaaa aaggcctgca gctggcggcg gcacaaggtg ggattcagcc 270001 gggcatggtt gcgatccggg atgagcgggc atcggaaacg gcggggttgc tgaagaagaa 270061 aaaagtgatt tgcgcgccgc gggaaaatgt tatccgtctc gctccccatt tttataatac 270121 gaaggaggaa atgcggcacg cgattgatga aatcgcggcg aaaacgatcc acaagtaaac 270181 atgaaaaagc ccctgaacac tagtcagggg cttttcatat taatgatcta ctttaacgcg 270241 tttcataaag aaagcgccaa ttaaaccgat aatggcaaca atcattgcaa acacaaatgc 270301 gtgctgtacg cctgctgtca aagcttgcgg gatgactgcc ggatcggcag ggtttttaac 270361 tgtactcata taatcatgct ggcctgcagc cataatgctg accgcaaccg ctgttccgat 270421 agcgccggcc atttgctgca gcgtgttcat aatggcggtg ccgtctggat aaaattcacg 270481 cggcagttgg tttaaaccgt ttgtctgtgc aggcatcatg atcatagaaa tcccgatcat 270541 caagcaggtg tgcaggatga taatcagcac agctgttgaa gtggtcgtga catttgagaa 270601 gaaccatagt acaacggtga caatcacaaa tcccggaatg acaagccatt tcggcccgta 270661 tttatcgaac aagcggcctg taacagggga cataaatcca tttaaaatac cgcccggcaa 270721 gagaacaaga ccagatgcaa atgcagtgag gactaagccg ccttgcagat acatcggcag 270781 aagcagcata gatgacagaa tgaccatcat acaaatgaac accatgatca cacccaaaat 270841 aaacatcggg tatttgaacg cacggaggtt catcataggc tgcttcattg tcagctggcg 270901 gattgaaaat aagataaggc cgacaacgcc gacaatcagc gacacgataa cagtcgggct 270961 ggaccatccc ccggagcctt cacccgcgtt gctgaatccg aatacaatgc cgccgaagcc 271021 aatcgtcgac aggatgatag acaatacatc gattttcggc tttgtcgttt cagatacatt 271081 ttgcatatat gcgataccga aaacaagcgc cagcacaagg aatggaagag agatccagaa 271141 aatccagtgc cagttgagat gctccagaac caatcctgag aaagttgggc cgatggcggg 271201 cgcgaacata atgacaagcc cgatcgttcc cattgcggca ccccgtttat gaggcgggaa 271261 aatcaccaag attgtgttaa acatcagcgg cagtaaaaga ccggttccaa gtgcctgaac 271321 gatccttgcc gctaataaaa acgagaagct cggcgcaagc gccgcaatga atgtacctaa 271381 aattgaaaag ataagtgaca cggtaaaaag ctgtcttgtt gtgaaccact gcaacagcag 271441 tcctgaaaca ggaacaagga taccgagtac aagcaggtag cccgtcgtta accattggac 271501 ggttgccgct gtaatgttca attccttcat aaggtcggtt aacgcaatat tcagcgctgt 271561 ttcactgaac atgccgataa aaccggccaa cagcaaggaa atcataatcg gcatcacttt 271621 gtattgctga gatgctttag ctgttgtttc caaaatcatt tcccctctct atcaactgca 271681 tgtagtatgt cgtttttttt atctcttcag caggtcagga atgcagctgg agatatgaag 271741 gagcggcgta ctgttttttg ccgtcaaaga taaaaggatg ccgccttcaa tcatcgcgtt 271801 aaccacagtg ctggcttctt ttgcacggct ctcgctgcag ccagtctgcc gcagtttttc 271861 ctcatacaca gaggcccatt ctttgtaggc ttcatgacag gcttcgcgca acggttcgct 271921 tttcaatgac gtctcagccg ctagcaagcc cacaggcaag ccttcaatgt cttccgtaca 271981 tgaaaactgg caggagagct ccttcaaaaa ggcttgaatg ccttccgctg gatcggtgca 272041 ggcttccatg cagtccgcga ttttctgacg gatatactcc ttcatctcat tcacggcttc 272101 gatcgcaagc tgttctttac ccccgggaaa gtggtagtaa agagagcctt taggcgcgcc 272161 gctttccttt ataatctggt tcagccccgt gccgtaatac ccttgcagct gaaaaagccg 272221 ggtagctgcc gaaaggattt tctcacggga atctccataa ctcataacat tcccacctta 272281 ctgaattgca atcaaaaata tagtgactgg tctattatct tgattcaatc atcaattgtc 272341 aagaaaaatt cattgtatga aaagacaaaa aaagaaggat atgacaacaa aaaatactga 272401 gagaaaagct gactgatctt ttgactgaat agataaaatg tacaatgatt aatcatcata 272461 tggatgtaag gagagaaata gatgaaaaaa caacgaatgc tcgtactttt taccgcacta 272521 ttgtttgttt ttaccggatg ttcacattct cctgaaacaa aagaatcccc gaaagaaaaa 272581 gctcagacac aaaaagtctc ttcggcttct gcctctgaaa aaaaggatct gccaaacatt 272641 agaattttag cgacaggagg cacgatagct ggtgccgatc aatcgaaaac ctcaacaact 272701 gaatataaag caggtgttgt cggcgttgaa tcactgatcg aggcagttcc agaaatgaag 272761 gacattgcaa acgtcagcgg cgagcagatt gttaacgtcg gcagcacaaa tattgataat 272821 aaaatattgc tgaagctggc gaaacgcatc aaccacttgc tcgcttcaga tgatgtagac 272881 ggaatcgtcg tgactcatgg aacagataca ttggaggaaa ccgcttattt tttgaatctt 272941 accgtgaaaa gtgataaacc ggttgttatt gtcggttcga tgagaccttc cacagccatc 273001 agcgctgatg ggccttctaa cctgtacaat gcagtgaaag tggcaggtgc ccctgaggca 273061 aaagggaaag ggacgcttgt tgttcttaac gaccggattg cctcagcccg atatgtcacc 273121 aaaacaaaca caactacaac agatacattt aaatcagaag aaatgggctt cgtcggaaca 273181 attgcagatg atatctattt taataatgag attacccgta agcatacgaa ggacacggat 273241 ttctcggttt ctaatcttga tgagctgccg caggttgaca ttatctatgg ataccaaaat 273301 gacggaagct acctgtttga cgctgctgta aaagccggag caaaggggat tgtatttgcc 273361 ggttctggga acgggtcttt atctgatgca gccgaaaaag gggcggacag cgcagtcaaa 273421 aaaggcgtta cagtggtgcg ctctacccgc acgggaaatg gtgtcgtcac accaaaccaa 273481 gactatgcgg aaaaggactt gctggcatcg aactctttaa acccccaaaa agcacggatg 273541 ttgctgatgc ttgcgcttac caaaacaaat gatcctcaaa aaatccaagc ttatttcaat 273601 gagtattgaa gaaaagaagg cgaataagcc ttcttttttt tggcttttta ggaccaataa 273661 tgacctctga atcttaaaat ttctttaaaa ataagccaaa attacccttt acttaattaa 273721 tttggtaacg taatataatt ggagaatttg ttacaaaaaa aggaggatat tatgaaattt 273781 gtaaaaagaa ggatcattgc acttgtaaca attttgatgc tgtctgttac atcgctgttt 273841 gcgttgcagc cgtcagcaaa agccgctgaa cacaatccag tcgttatggt tcacggtatt 273901 ggaggggcat cattcaattt tgcgggaatt aagagctatc tcgtatctca gggctggtcg 273961 cgggacaagc tgtatgcagt tgatttttgg gacaagacag gcacaaatta taacaatgga 274021 ccggtattat cacgatttgt gcaaaaggtt ttagatgaaa cgggtgcgaa aaaagtggat 274081 attgtcgctc acagcatggg gggcgcgaac acactttact acataaaaaa tctggacggc 274141 ggaaataaag ttgcaaacgt cgtgacgctt ggcggcgcga accgtttgac gacaggcaag 274201 gcgcttccgg gaacagatcc aaatcaaaag attttataca catccattta cagcagtgcc 274261 gatatgattg tcatgaatta cttatcaaga ttagatggtg ctagaaacgt tcaaatccat 274321 ggcgttggac acatcggcct tctgtacagc agccaagtca acagcctgat taaagaaggg 274381 ctgaacggcg ggggccagaa tacgaattaa tgaaaaacaa aaccttgaag aatgctattc 274441 ttcaaggtta ttctgctttc agcacaatgg ttttcgcagc catatcatga acggtttgtt 274501 ttttcttcgt aaatgcggca gtcaaataga tcaggcggga gaacacatgc acccacgcta 274561 tcaggtaacg gacaatggct tgcgggaagg atattttttt atatgtttcg tccctcacga 274621 tttgcagccc gatgattttt ttgcctagtg tgcccttcca atttgtcagc ggcatcagca 274681 aagggtacac aatcagcatc aatatggcga caataatgac accggcggac ccatcgccaa 274741 acgtaaatcc ggctgccaaa atcactgctg cggcaatgat tacatcaagt aaaagagcgc 274801 aggcgcgcag catgaaacca gctagttcca atagaaacac tccttaaaat gttaaataaa 274861 cacctaatga ttgtaaaaaa gaagggccta aagtgggaat aggtgataag ccttaaatca 274921 caaaagttgg tgaaaatgtc ataggtaaat tggcataatc agccagctta tcacattacc 274981 aaattctttt ttagcccgaa accaagccct cagaagttat ttttgttaaa atagaaaagt 275041 tacaacagaa ttcggagggt ttattgtggg aaaagtgaaa cgaaatgccc cttgcccatg 275101 cggcagcggc aagaaatata aaaaatgctg cggaagtaaa gttgtcgact tcccggcgga 275161 actagcggca aaagaagcga aacaaattca ggaagactta gtggagtatg ccttcacagt 275221 acatagagaa agcatttcag gctttatcaa ccagcatgat tttctttctg ctatggacag 275281 acagacgaaa gacatcagcg tatttaactt aggaatctgg ggaatcttct tccacccgct 275341 tgctggtgag aagacaatct tcgaagagta ccttcagaaa aaaggcgatt cgatcactcg 275401 tccgaaaacg cgtgagatcg tagaatcatg gcagagcatg acgcctgctt tattgctgct 275461 gaaggacctg aaggaaggca tcattcactt tgaagatgtc attacggcaa aacaattcga 275521 agtggaaatg gacgccagca atcaagacct tcctccagtg ggaagcctga ttcttggata 275581 cccaatccac gaagcggaaa aagcagaatt cttcatgcag ttcacgatct tcccggtgaa 275641 gagaacagaa gcgctgatca gcaaggtgaa gaaatatgcg gatgccgctg tgaaggacgg 275701 caaaacgccg gaggacttca tgaagcagga attcaacaac gttctgttcg cgttgttagc 275761 tgagaaagat gaagagccac aagcagagaa agcggaagta agcactgttg agtgggcaaa 275821 cgacttggag aaagaaaccg ctgcggctat tgaagaaggc atgagcgggg aagagtatcc 275881 gactgaattg atcccagctg ttattgacat ctggaaaaca ttctgcgaga aaaaatcacc 275941 tgtcatcaga aagccggaag cttttgcggc ggcagttgaa tattatgtaa acgcaatttc 276001 tcttaacggc gcgtccgttt cccaggctaa actggcgaaa aaatacggcg ttagcgcatc 276061 aacgatttcc agccgttaca aagaaattga aagcacgctg caagatgaag cagatcgttt 276121 tgcacaagcg ttatcctcat aatggaaaaa accttgaaaa gccaggcttt tcaaggtttt 276181 tttatttctg aaacggaatt ttgatttcta accggaagat ggggtggcgg taggtaaaat 276241 ccagcctgcc aaaagcgccc ttcaccagtt tttgaatgat atatgtgccc atgccttcat 276301 gagcgccgtt tttcgttgag cggccaaacg attgataaat tgtatcgagc acttttgggt 276361 ccatcccggg agtgctgttt tcacaagtca gtacataaag cccgctgcgc agtgaagtct 276421 ccagtttaat ctctgctttt tctcgggcct ccgccgcgct gtcgagcgca ttttctaata 276481 tgttgccgac caagctgacc tgatcagcag gcgaaaacgg aagggaagaa agcggtgtat 276541 gcatatgcag cgaaacactc acattcgagg cgcgggcttt ttctaaaaaa tcataaagca 276601 cccctgcaac gtacgcgttc tctcctttca aaaaacggtc atattggctg tattgatccg 276661 cccagttttg aatatatgct tgtgtatctg ccttgggctg agctgatttg attgcagtga 276721 tatgtttcat tgtgtcatga ttccggcttc tgacatcaat cagcatttga ttggcgtgct 276781 gttcagcttg agtcagctta tcaatttgat cagaaagcct tgcctgcaaa gcagactgtc 276841 cgatacggag cccttcacac cctgcaaata tcgcgattac acataatacc ggcatgatgt 276901 ctgtgccaat caacaccact cccaccgaca tcacttgaat caccgcaatc cacgcacaaa 276961 gccctgagga acagtgtttc cacacccgct tcgtattcca aatgtacaat cctgcagcag 277021 ctgcgcctaa agcagcggcg agccaagagg cggctgtgct gtgtgaaaaa gcagcagctc 277081 cctgataaca tatgaaacta aataaaatca gataaagaca ttgaaaaagg gtaatcacgt 277141 actaaactcc tcaaaaatag tagttttgaa aataatcaag ctgctgctta gtgatcatcg 277201 cttttttaga cgttccctca aaggaaactg tgaatgaatg cttggtataa gcggaaaaat 277261 gctttatgta atgaatgttg ataataaagg aacgatgcga acgaagaaaa tctttttcgg 277321 gcaggtcgcc tttaatatca tttaatgttt gatacgtttg cacctcttcg gcggttgtca 277381 caatcgtcgt cgaacgtccc gtccgttctg cgaaaataat atccttcttt tgcaggacgt 277441 gcatttcaga cttttgcttt atcaatatac gcccattcaa actcgtttcc gttttctttt 277501 tcaagtaccg gtcgaaggaa gcggccagac ggtcggcata gtacggcttc ataatataat 277561 catggacgtt caggtcaaag gcgtgaaccg cataaccgcc gtggccggta acaaaaatca 277621 catccacatc aagtgaatgg gatttgatca aatcagcaag ctcgtagcca gacatatggg 277681 gcatctcgat atcggcaagc agcagatcaa tgtctccgtt ctttacccgc ctgtaggctt 277741 ccttcgctga atcggtggaa aagacaattt cgacgtcctg cattctggac acgatcgctt 277801 ctaacttctc taaatctact cgataatcat ctacaagtcc gacttttacc attatcattc 277861 ccctagttac atagaatcat ctttattcta tcccatttca cgacataaaa agaactcttc 277921 gcgacaactt tatccaacta atccagcttt tcgtatatag tcattactag aaataaagat 277981 aagggagatt gtgacatgat tacactgacc gattgcagcc gcaggtttca ggataagaaa 278041 aaagtagtca aagcggtgcg agatgtaagc ttaacaattg aaaaaggaga agtcgtcggc 278101 attctcggag aaaacggtgc cggcaaaacg acgatgctga gaatgattgc ttccttgctt 278161 gaaccatcac agggtgtaat cacagtagac ggctttgaca cggtcaagca gccggctgag 278221 gtcaaacaaa gaatcggtgt cttattcgga ggagaaaccg ggctttacga caggatgacc 278281 gctaaagaaa atctccaata cttcggcagg ctgtatgggc tgaaccgcca cgagatcaaa 278341 gcaagaatag aagatttatc gaaacggttc ggcatgcgcg attatatgaa ccggagagtg 278401 ggcgggtttt cgaaaggcat gaggcagaaa gtcgccattg ccagagcgct gattcacgat 278461 ccggacatca ttttatttga tgagccgaca actgggcttg atattacgtc aagcaacatc 278521 ttccgcgaat ttatacagca gctgaaaaga gaacaaaaaa cgattctttt ctccagccac 278581 attatggagg aagtgcaggc gctctgtgac agtgtcatca tgattcacag cggagaggtg 278641 atttaccgag gggcgcttga atcactatac gagagcgagc gcagtgagga tttgaattac 278701 atctttatgt ctaagcttgt cagggggatt tcttaaatgc tgagccatat ttataaaaaa 278761 gaaatgatcg acgctttacg cgacagaaaa acgatattac tcacaatctt agtgccgatg 278821 attatgatgc ttggacttgt ctttttttat gaaagcatgc tgtccgacaa aggggagcag 278881 tacacgctgg ctgtcggcca ttcgcttccg cccgcactgg aaagcaagct taatgagatt 278941 gacgaaatca gcgtaaaaac atttgcaaag cctgaagagg cagttgatga aggaaaagca 279001 gatgcctatc tgaacgtccc gaaagagttc gactcatatg tcaacagcat gacacctttt 279061 aaggttgatg tttacggcaa ttcaatcgat caagggtcgt caaatgccat gcagcttgtg 279121 cagtctgcct tagatcagta caaaaatgaa attgtgcagc aacgtttaac aaataagcat 279181 attgatcaat cggtgatcca gccgtttaca attcagcaaa aggaagcgga tgaggagaaa 279241 gggacttccg ctattatgct ttccgccatt ctgcccatgc tgattctgac ttccattgtt 279301 tccggcgcaa tgccgatcgc tcttgatatc atggccggtg aaaaggaccg aaagtcaatc 279361 gaggcgctgc tattaacgcc agtcagcaga aacaaagtgc tggtcggcaa gtggcttgcg 279421 gtttccactt ttggcgtggc ttcaggtgta tttgctttgg tgtttttgat tttgtccacc 279481 gtgttattta ccgaaaattt aaaaacggcc ttccagctgg gagatcatat gtggagtgta 279541 atcggcgctt cagccttaat cattgtgctc tctgcattgc tgatatctgc gatggagctt 279601 ttcatcagca tcatgtccag ctcggtaaaa gaagcgcaaa gttatatgtc tctcgtcgtc 279661 tttctgcctg tgttcccgat gtttttcatc ttcagcaagg caccgaacca atttgactta 279721 tcatactttc tcatcccgtt tctgaacctg catgcgttat ttaaacagct tttattcggg 279781 atggttgacc cggctaccat tttgtctacg tcaggaacca tcgccgtgct catcgccatc 279841 ttctttttac tagccagagc ctgcttcctg aaagacaaat gggttcttcc aaaataaact 279901 tgcgaaagga gaaatacact ttctcctttt tgtatatcct gaaaaaagaa ggaaaataga 279961 aaaaggatat ctaatacaaa aagtgaccct gcactatttt tcatcaaaat tggtttcaaa 280021 ggagaaggaa caatggatca aacacgtaca ctcggcaaaa cgaagctgaa ggtgaagcgg 280081 atcggattcg gcgcgaatgc ggtcggcggg cataatctat ttccaaatct aaatgatgaa 280141 acagggaagg atttagtgcg cacggcattg gatggcggcg tcaattttat cgataccgcc 280201 tttatatatg gattggggcg atctgaagaa ttaatcggcg aagtcgtaca ggaacgcggc 280261 gtgcggaatg agctcatcat cgccaccaaa ggagctcata aagaagtgga cggcagcatt 280321 gaattagaca atagccggga gtttcttcgc agcgaggtgg agaagagcct gaagcggctg 280381 aaaacagatt acattgattt gtattatgtt cactttccgg atggaaaaac acctctcgct 280441 gaagtggcgg gcactttgaa agagctgaag gatgagggga aaatcaaagc gatcggcgct 280501 tcgaacctcg attatcagca attgcaggat tttaatgctg acggctattt ggaggtcttc 280561 caggccgaat attctctcat acagcgtgat gccgagaaag agcttcttcc atactgtgaa 280621 aaacaaggca tctcctttat tccttacttt ccgcttgcgt ccggactgct gacaggaaaa 280681 ttcacgcaag acacagtctt tgatgatttc agaaaggata aacctcaatt tcagggtgaa 280741 acgtttatcc acaatctcaa aaaagtagat aagctgaaag cagtagcgga ggaaaaacaa 280801 gcggatacgg cacatgtcgc cttggcgtgg ctgttaacga gaccggcgat tgatgccatt 280861 attccaggag ctaaacgacc ggagcaatta caggataacc tgaaaacctt gaacattgaa 280921 ctgaccgaag atgaagtgaa tttcatcagc gacattttca aataaaaaag gaaatagccg 280981 tcatggctat ttccttttgg tgttttattc tttgatgaat gcttcgacta attctgctgc 281041 tctgtaatca tccatatcaa gctgccattg gtcgatgtca tttttcttca ttttcacttc 281101 aactgttttt tcagatgaag caggtccaag ctttttgaat tcctcaggat agacttgaag 281161 cgcgtatttc actgcctctt catagctggc actagagttt ttactgtagt agtctttcac 281221 tttgtcttcg atgcggtctg aaagagaaga tgcatctaca ggtttaactg tggcttcaac 281281 aattgcttcg tctttagaga ttgaagtcgt ttttgcttga atggaagagt ttttgcttaa 281341 tccctcttta atgccgttca cgatattatc aagcgctttg ctgtccgcat atgtgctgga 281401 aaggccggaa gctgagagat aaccgtcttt ggctgattca ttaaaatcat ttacaatttc 281461 atttttgtta gcgccggtga ttttttcgaa atcggcgtta tctttgccga aaagaaggac 281521 atcaacataa gctgataacg cttttgcaga atcttggagc ttatctgccg tcgccaggat 281581 ttttttgtct tttccgtcaa ttttaaaagt aactgatttt ggctttttat caccgtaaga 281641 ttccggcgta tagttaagct cgtattgctt gcctttatct acaacgaaga aaagatttcc 281701 ttcaacggat ttgtcagcgt taatcgtgct gccctgaagc ttttcgctat agtcttcagg 281761 gtctgtgtca gacattttgg tatcaccttg atacaatgtg aaatccatac tgtctacatt 281821 cagcgggtct tttcctgtgt ttttcaccgc gacattgact tttaacacaa gctggtcatc 281881 tgaagtggac ttatcatatt tagacggaag tgtgtaagag acatccttga ttttgacttg 281941 agctatatct gagctttttt ctgtttctga ttctttcttc tccgcgcttg ttttgctgcc 282001 ggaacaagca gctgtaaaca tcatcagcag aagaattagg aaaacagcgt acgttttttt 282061 ctgaaacatt catttttcct cctcaaatgg tttaggaaag gggagtcttt tgtctttgag 282121 aaatggatct ttttgaatgg attagcatca tataaccaaa aaaatcagtt cttttctcac 282181 ggttttcacc ggattttctg gaaactccgc cctcctttgt catgaatgga cctataaaaa 282241 gttacaacgg aattaatttt aagattatta gcttttatat tgaataggtt catcatccta 282301 tttttggtga aaaatgttct ggtaaaactg gtaaactcag aaaactgtgt attttagact 282361 attacttttt gattagttgg agggaactta agaaggatga aaggggccgc ctttgtgaag 282421 aaagagggac tgaaacaaaa agcactggaa atcggccggg tgccgacaca cttaaaactg 282481 gaaattgaag attatggcgg tgatgataaa agagctcatt tttgttgggc agatcctcag 282541 gatgagaata ccggcattat cgtggagctt ggaccggacg gagagctgga atccctttcc 282601 cgtgatattg agcctgaaag cggagaaagg ctgtctgagg agaaactaga ggatatcatg 282661 cgccaatttg tcgagactca tcatccgggg gcactctctg cctttgttcg tgaagaaaat 282721 gaccgtgcat acggcgataa agtgagattt tcatatgttc aaatggaggc tgggcttcct 282781 ctccccatga gcggatttat ggctgatgtt tccttatcag gtgagattgt ttacttccgt 282841 tattacggcg aagcgggcag catcatcaag ccaaagcggg tcgcggatgt tgaagaggca 282901 cttgccttta tcaagaagga cgtggagttc gaccttttgt ttgaggttct ccatcgttct 282961 gtttacaaaa acggagatga tcagccgcat ttggtgtacg agcctgaagg tagggcgatt 283021 accgtacctg cggatttggt tcaagaagaa caagcagttg atgatgacga tgattacagg 283081 gagccggaga gctttcctct ccctttattc gagggcatcc gcgaaaaggc cgatcctgac 283141 agcatgattg gtattgaaaa tgggtttgtc aaagagcggg aagcggattt gggagatggg 283201 agaattggaa tcgtttggcg gaatccggat gaccctgtgt atcagccggc ggataaaagc 283261 atggacagct ggtttaaggg acggactcat caagtgctga aaaccatcta taacaaagaa 283321 accggaaaac tcgaaggcgt catgtcattt atggagaaaa aagggccgct gacagtaacc 283381 ttggcagagt gtgaaaaaat cgcgcttcgc tttctatttg ctttatttcc gaatgccgat 283441 caatatttta ggatcagata cgacgaaaaa gatgaagaag aaaacgcagt cgctggtttt 283501 acgtttgaag cgcattgtca cggagttccg ctccgatttg ggcagatcag aatttgtgtc 283561 agccgccaga cagggtatat caccgtttat atgggaccgg atattgaccc aaataagctg 283621 gcaaccattg atcctgtgcc ggctatttca gttgaacaag ccaagtctat cttttggcag 283681 cattttaaag ttgagcttgg ctgggaaaga gagtacgggg atgatgaaga acacagctac 283741 cggctcgtct ataagccggt gtatccgcat tttatcgatg cacatacagg ggagcctgtc 283801 ttcagcatat ggtgaaacag ccaaaagtca cgcaattgcc tcagatatag aagagagtat 283861 gtgatgaaag taacagaaag aatctcaaaa aacaatgaca ataatagaaa aggacctttc 283921 ttcactttaa atgaagaaag gtctttttat ataataaaca ggattctctt tgtcgtagac 283981 tctttgaaag ggatgacttc attggttaat aaacagctga aaaagaaggc gcaggagatc 284041 ggaaatgtac cgacgcatta tgagcttgag atagaagatt acgaccaaaa gcaaaagaag 284101 tacgggcagg catattttat ctggaaggac cctaaagatc cggaaaagca cattacagtt 284161 gaacttagaa atgacggcgc cttgctcacc ttttcaacaa ctgtccactc cgagacagac 284221 aaaaaacttc cagatgccga gctgaagctg acggctcttc agtttgccgc tgccaatcat 284281 cccggcacat ttatgaattt tcattttcaa ggcaaggaag aaagggggca gcacatccgg 284341 tttgtctata ccaaaatgga gctggggctt ccgattccca attcaggctt tttaattgat 284401 atgacacgaa gcggtcagat tgtccacttt ctatattacg gggaagggca taaagccgaa 284461 gttccgacgg aatttgtagc aaaagagaag gttgtatccc attacttaaa cacaatgtct 284521 tttgagctga tgtacgatgt cattgatggc gaacaggaac caaggcttgt atatgaaccg 284581 attctaccgg gatacagcta tcccgcagat gtagacgaaa ttgtgcccga ccagcatatc 284641 gcagatgaaa gaatagaaaa cacggcgcca ctgccgccgc ttcagaacaa ggaagaagtt 284701 gatatatttg ccttgctggg ttttacctct gatatgcaga aagtcagtga aagagacttt 284761 ggagaacaaa ttggaagcac gtggcgcagg ggcgctgcgc cggagcgtaa ggatttaagc 284821 ataggaagct attttgaaac gagaaataaa aatacaatca aaatgaagac ggataaaaga 284881 accggaaaat taaaagcagc gctttctttt atggactggc ggaacaacct ccaatgctcc 284941 acggaagaat gccaagagat agcgcttcaa tttttgtatg ccctctatcc gagagcggct 285001 gagtttttca gggtgaatcc cgtccgaatt gatgaaagag ggagagtccg caaccatttt 285061 tctgtctggt ataaaggagt gccgctgcgg ttcggcgctg cccgcatcat tgtcaatccg 285121 gaaactgggt tgattgacgc ttttatggcg cctgatattg aacctgaaca attggaagcg 285181 ataaatcaca ggccggatgt ttccgctgaa gaagcgaaag aagcattttt agccgctttt 285241 gatgtgaaac tggaatggca gcctgatttt acagcaggca gtgaccagca ctgcaaactt 285301 gtctataagc cggtttaccc ttcctatatt gatgcgcaca taaggaaaaa gaaaaggctg 285361 tgaggggtgt ctagttagga atcatctcca agtgggggta gtccttgaat cgtttccaat 285421 ccccgcccca ttcgaaaccg agtgtcttag cgatctcgac aacctccagc caatctgatt 285481 ttccgttttg attgccgtca tattccatat cccatatgat gctgccatcc tttttttgaa 285541 gggcgaaatc aatcgctaaa ccatagttat gatacgattc ccctcctctt gcataggtga 285601 caatattccc tttttttgta cgtccctgtt tatataattc atcttgttcc ttaaaggacc 285661 tgaatccttc agtaatgacg acgtcaatgc ctttattcgc tgcagcggct ttgagtgcat 285721 cggcattctg cttcacaatc ggatgaagat ccgaggggac aggcatgtcc tgcaaggcgt 285781 tttgagaatg ccattcatgc cgaatataac taaaacaaag atctagaaga aatagaatac 285841 ataagataac aaatgttttt gcgggtaagt tcatatcggt ctcactttct caagatgtgc 285901 tgaatgttaa cgcttttaag tgattgactc tctctaaaag cgaacagcta tgataaaata 285961 taacataaat agtagcagga ggaaggaggc agaccgatga gagcaaagat tccatcagaa 286021 gaagtagcag taaagctgaa tgaatggtac aagctcattc gcgcatttga agcagatcaa 286081 gcagaagcgt taaagcagga gattgaatat gatttagaag atatggaaga gaatcaggac 286141 ttgcttttat atttttcttt gatggaattc cggcatcgaa tcatgcttga taagctgatg 286201 ccggtgaaag acagcgatac caagcctccg ttctctgata tgctgaacga aattgaaagc 286261 aatcagcaaa aactcacggg cttactggaa tactactttt attatttcag aggaatgtac 286321 gaattcaagc agaaaaattt catattagcg attgaccatt ataaacatgc cgaggaaaag 286381 ctcgagtatg tcgaggatga gatcgaaaaa gctgagtttc tttttaaagt cgcagaagtg 286441 tattatcaca tcaaacaaac gtatttttcc atgaattatg cgagccaggc gcttgatatc 286501 tatacgaaat atgaactgta cggtcgccgc cgggttcagt gtgaatttat catcgccgga 286561 aatttgaccg atgtgtatca tcatgaaaaa gcactgaccc acttgtgcag cgctttagaa 286621 catgccaggc agcttgaaga agcgtacatg atcgctgctg cctattataa tgtcggacac 286681 tgtaagtaca gtctgggtga ttacaaagaa gcggagggct atttcaaaac agccgccgcc 286741 atttttgagg agcacaactt tcagcaagct gttcaagctg tattttcact gacccatatc 286801 tactgtaaag agggaaaata cgacaaggca gtagaggctt atgaccgcgg gataaagagc 286861 gcggctgaat gggaggatga catgtacttg acgaaattcc gcctcattca tgagctgtat 286921 cttggaagcg gcgacctgaa cgtgcttaca gaatgctttg acctgctgga atccaggcag 286981 cttcttgctg acgccgaaga tctgctgcat gatacagcgg aacgtttcaa tcagttggaa 287041 cattacgagt ccgccgcttt cttttaccgc aggctgatga atattaaaaa gaagcttgcc 287101 gagcagcgtt ttcaatagga aatggcagag aactacaggt tctctgcttt ttttgtgctg 287161 ttttcaactc ggaaaaacag ggtattttcc actgcatagt gagaaacaga ggaggatatc 287221 aagtatgtac aaagatttaa ccggaaaaac agcgattgtg acagggtctt caaaaggaat 287281 cgggaaagcc attgcggaac ggttcggaaa ggagaaaatg aatgttgttg taaattacca 287341 cagcgacccg tctggagcag atgaaactct ggaaatcatt aagcagaacg gagggaaagc 287401 cgtctcagtt gaggcggacg tgtcaaaaga agaggggatt caggcgctct tggacacagc 287461 tttagagcat ttcggcacgc tcgatgtgat ggtaaacaac tccggtttta acggcgttga 287521 ggcgatgccg catgagatga gtcttgaaga ttggcagaga gtgattgatg tcaatgttac 287581 cggaaccttt ctgggagcga aagcagcact taaccacatg atgaaaaaca atatcaaggg 287641 caatgtgctg aatatctcaa gtgttcatca gcagattccg cgccctgtaa acgttcagta 287701 ttccacatcc aaaggcggca tcaagatgat gacggaaacg ctggcgctca attatgcgga 287761 taagggaatc cgcgtcaatg cgatagcgcc cggcaccatt gccacagaat caaatgttga 287821 tacgaaaaag gaagagagca ggcaaaaaca attgaaaaaa atcccgatga aagccttcgg 287881 aaagcctgaa gaagtggcgg cagcagcagc ttggctcgta tctgaggaag caagctatgt 287941 gaccggcgca acacttttcg tcgacggcgg aatgacactt tatccatctc agcttgaata 288001 gaagacaaaa cagggggatt gcgggatgaa aacagactgg tggaaggatg cagtggtgta 288061 ccaaatttac ccgagaagct ttcaggacag caatggagac ggaattgggg acttgcgggg 288121 gattatttcc cgtcttgact acataaagga gctcggggca gatgtgattt ggatttgccc 288181 gatctatcct tctccgaatg ttgattacgg ctatgatgtg acaaaccata aggcgattat 288241 ggattcttac ggaacaatgg acgattttca cgagctgctg gaccaggtgc atcagcgggg 288301 attaaagctg gtgatggact ttgtgttaaa tcacacctcg gtcgagcatc cgtggtttaa 288361 agaagcggag ctggacaaaa acagcaaata ccgtagctat tattattggc gtcccggcac 288421 aaagaacggc ccgccgacgg actggctctc aaactatgga tgcccggtct ggcaatacga 288481 agagcacacc ggagaatact atctccatat gaatgccgtc aaacaagctg atttaaactg 288541 ggaaaatccc gaagttcgcc aggcggtgta tgacatgatg aaattttggc tcgataaagg 288601 ggtcgacggt ttgcgaattg atcagctcca tctcatttct aagaaagaat atcttccttc 288661 gtatgaggac tatatcaatc agcaggcaga gccgaagccc tttcagccaa atggcgaacg 288721 aatccatgac tatttaaaag aaatcacaga tgaagtgttt tctcattatg atgtcatgtc 288781 tgtcggagag gtcggcagtg tcacaccgga agaaggcctg aaatatacgg gaacagataa 288841 gcatgagctg aatatgattt ttcactttca gcatatggag cttgatcagc agcccggaaa 288901 agaacattgg gatttgaagc cccttgagct ttctgattta aaatcggttt tgacaaaatg 288961 gcaaaagaag cttgaacatc aaggctggaa tacattgttt tggtgcaacc acgaccagcc 289021 ccggattgtg tccagattcg gagacgatgg ggaataccgc aaagcatcag cgaaaatgct 289081 ggcagccgta atttatttta tgaagggcac gccgtatatt tatcagggag aagaaatcgg 289141 gatgacaaac gcgccgttca cccggattga agactacaaa gatatccaaa cgatcaatat 289201 gtatcataaa cgggtgtttg aaaaaggcta tgatccaaat gatgtgatga gatcgatctt 289261 agccaaaagc cgggatcacg cccggacccc gatgcagtgg aacagcggca aaaatgccgg 289321 atttactgac ggcacgcctt ggctgaaggt caatccgaac ttcaccgcaa tcaatgtgga 289381 ggaagcgcag ggagatcctg attctgtctt aaactattac aaaaagctga tcagcctgag 289441 aaagcagtac gctgacctca tgaaagggag ctttgatctt ttgcttccgg acgatccgca 289501 gttgtttgta tacatgagag aaaacagtaa acaacagctt ttgtcggtca ataatttttc 289561 aaaagagcag gctgtttttc agtggcctaa gaactgcggc aaagctcagg cctcactgct 289621 tctcagcaat tataacaacg atgatcttga tgacgaaatg gtgttccggc cttatgagag 289681 cagggtctat cttctggaca aaacaaacta atgattgaag tagcccggca tttttagccg 289741 ggttttttta gtacatatat tcgctctgca ggcgggaaga ataaatgaaa atgaaattta 289801 ttcttgcaaa acgtaatgac ttcggtttat tatgatatag gattacaaaa tcgttatcat 289861 tttgatttaa agttactgaa aaagagggga tatacgatat gtttaaaaaa tggagcggtt 289921 tgtttgtgat tgcagcgtgc tttttattag ttgcagcatg cggcaactca tcaacaaaag 289981 ggtcggcgga ttcaaagggt gataaactgc acgttgtcac aacgttctac ccgatgtatg 290041 aattcacaaa acaaattgta aaagacaaag gcgatgtgga tctgttaatc ccatcttccg 290101 ttgaaccgca tgattgggaa ccgacgccga aagacattgc caacattcag gatgctgatt 290161 tgttcgttta taatagtgaa tacatggaga catgggttcc gtcagctgaa aaaagcatgg 290221 gccaaggcca tgccgttttc gttaatgcaa gcaaaggcat tgatttaatg gaaggctctg 290281 aagaagaaca cgaagagcat gatcatgggg agcatgagca cagtcatgca atggaccctc 290341 acgtatggct tagccctgtt ctggcacaga aggaagttaa aaatattacg gctcaaatcg 290401 tgaagcagga cccggataac aaagaatact atgagaaaaa tagtaaagaa tatattgcaa 290461 aactgcagga tcttgataaa ctatatcgta caaccgcaaa aaaagcggag aaaaaagaat 290521 ttatcacgca gcatacagct tttggctatc tggcaaaaga atacggcttg aagcaggttc 290581 cgattgcagg gctttcacct gaccaagaac cgagcgcagc cagcttggca aagctgaaaa 290641 catatgccaa agaacataat gtaaaagtta tttactttga agaaattgca tcctcaaagg 290701 tcgcagatac gctcgccagt gaaatcggcg cgaagacaga agtgctgaat acactggaag 290761 gcttgagcaa agaagaacag gataaaggtt tagggtatat cgacattatg aaacaaaacc 290821 tcgatgccct gaaagattca ctattggtta aatcataaga tagtgtgcgc cggaggggtg 290881 cacactattt ctttgtgaga aaggaagatt aacatgaatc tcgtctcatt gaaagatatc 290941 gttttcggct attcccatac gcctgtttta gataaagtat cacttgatat tgaaagcggt 291001 gagttcgtcg gcatcactgg accaaacggc gcctctaaat cgacgctcat aaaggtaatg 291061 ctcggcatgc tgaaaccgtg ggaaggcaca gtgacgatca gtaaaaggaa tacagaaggg 291121 aaacgcctga ccatagggta cgtcccgcag caaatttctt catttaatgc cggatttccg 291181 agcacggtgc tggagcttgt tcagtcaggc cgctatacaa aagggaaatg gtttaaacgt 291241 ttaaatgaag aagatcatct tgaagtagaa aaagcattga aaatggtgga aatgtgggac 291301 ctccgccatc gtaaaatcgg tgatttatca ggcggacaga aacagaaaat ctgtatcgcc 291361 agaatgctcg ccagcaaccc ggatctgctg atgctggacg aaccgacgac agctgttgat 291421 tacgacagca gaaaaggatt ttacgaattt atgcatcatc tcgtgaaaaa tcacaaccgc 291481 acagttgtga tggttactca cgaacaaaac gaagtacagc aatttttaga taaagtgatt 291541 cgattagaga gaggagaaaa aggcggatgg aaatgtttga cttggaattc atgcgacgag 291601 cttttctagc aggcggcatg atcgccgtca tggctccgat actaggagtg tatctcgttc 291661 tcagaagaca ggccttaatg gctgacacac tttcacatat ctcattgtca ggtgttgcca 291721 tcggcttttt tctcagcacc aatataaccg cagcaagcat agtcgtcgtg accatcggcg 291781 cgatcggaat tgaatacatg cggcgggcgt atcggactta ttcagaagtg tccattgcca 291841 tcttaatggc agctggtttg tccttcgcga tgtttttaat cagcctttcc aaaggcacag 291901 ccaatatgag catcgatcaa tacctatttg gatcgcttgt gacagtaaac cagcagcagg 291961 tctatattat cagtattatc acactgctga tcctgcttta ttttattgta ctgagaaggc 292021 cgctctacct gctgacgttt gatgaagcta cagccaaaac atcgggaatc aatacaaacg 292081 ttctctcgtt gtcattcagt attgtcacag gccttgcgat ttcagtcatt attccgatca 292141 tcggggtcct tcttgtatcg gccctgctcg tattgccggc agccttcgcc atcagaattg 292201 caaaaggctt taacatggtt ttcattacag ccatactcat ttcattattc agcgtattta 292261 cgggactgac atcatcctat cagctcggga cgccgccagg tccgtctatt accctgctat 292321 tgatcgtttt gctattaatc ggatttgcag ttcagggagt ttggacgttt atcaaaaaag 292381 aagctcagcg caaaaaaaga agccgataac atgaaaagca gttttcccta gggaaaactg 292441 ctttttttat agaaacaatt cggcaaggcg ctcataagat tcttttttcg cctcaaaatc 292501 aaacacattg cacagaacca tgatttcatt tgtttcgtag cagcctgtga ggtctaacag 292561 ctgttgtttg acagtggtgg gagaaccgat caccatccgc tttctgtttt cttctatgag 292621 ttttttatcg gacgctgtat agggatgagc tttcgcttcc tcgatgcttg gcacgcggct 292681 gtccaagcct tttccgacgc gaagaagcca cagatcctgg cttaatgcga gttcttctgc 292741 ctcttcatct gtttttgcgc aaatgacaaa aatcgtaaac agtgcggatg gattcgaaaa 292801 atgggctgag ggccgaaagc tttcccggta gatgcggaat gcattttctc ctcgctcggg 292861 attaatgaaa tgcccaaata catatccaat cccctggtgc gccgcgcgtc ttgcgctgtt 292921 ttcaccaaga ccgagcaccc atagctcggg tgccgtacca ataaggggcg ccgctttgat 292981 tccggcatac ggatggtcgg gaggaaggga atctgttaga aaataagaga catcctgcag 293041 ctgtctgtta aattcggtta agcttttttt caccccgtcc gttaatgcaa gtctggtttt 293101 tgtcgtgccg ccgggggagc gaccgacgcc gaggtcaatc cggtttggat acagggcctc 293161 aagctggcga aaggtttcag ccactttaaa tgggctgtat tggggcagaa gcacgccgcc 293221 tgatccgaca cgaatggtgt ttgtctgtgc tgcgatgcgg gcgatcatga tttcaggcgc 293281 tgtgcttgcc agtcctttcg tgctgtgatg ctcggcaaac caataacgct tatagcccca 293341 ctgttcgctt aattgggcaa gctcaaccga atgctggaga gttgtcacag ggctttctcc 293401 tttagaaaca ggtgcctgat caagtatgct taaatgaatc aaaaggccgc ttcctttctg 293461 tctgttttta gatggtgaca ccagaatagg caaaatgact tgcccgcgtc aaatggtttg 293521 tttaagaagc gcactttata gcatttgcaa atcatatatc aaatatggaa gttttttttc 293581 gaggtttttc gtcaattatt cttaactttt acgaaacttt gatataataa caaacgtata 293641 tattagtaat ttacggctta ttttccttgt gagcgtaaaa ataaatgtga ctatcttcac 293701 attttgatga gtaggagtga atcgtgtggc aatttcttta gaaaaaggtc aacgaattga 293761 tttaacaaaa ggaaaagccg gtctgtcaaa attgatggtc ggtctcggct gggacccagt 293821 gtcctcaggc ggaggattct tcagcaaact gcttggcgga ggcggtccga atatcgactg 293881 tgacgcttca gtgctgatgc tggaaaacgg aaaattcacc gataagaaaa acctgattta 293941 tttcggcaac ctgaaaagcc gctgcggcgg tgtacagcat acaggcgaca acctgacggg 294001 tgacggtgcg ggcgatgacg agcaaattat gatagattta gataaagtgc ctggaaacat 294061 cgataagctt gtatttgtag tgaacattta cgattgtgtc agaagaaaac aagatttcgg 294121 catgattcaa aatgcgttta tccgcgtagt tgatcaatct aatcacgagg aaatgctcaa 294181 gtacaatttg agagacaatt acgccggcag aacaagcctg attacagcag aaatctaccg 294241 cagcggcagt gagtggaagt ttgcggcggt cggtgaaggc acaaacgata cgagattaga 294301 agatattatc agtcgatacg tataaaagaa aaggagtgga tgaaacatga caatttcatt 294361 ggcaaaagga caaaaagtag atttaacaaa aacaaatccg ggtctttcaa aggttgttgt 294421 cggtttaggc tgggatacga acaagtatga cggcgggcac gactttgatc ttgactcaag 294481 tgtgtttctg ttagacgccg cgggcaaatg cgcgtcacca aacgacttta ttttctacaa 294541 ccagcttgaa ggcggcaacg gttcagtcgt tcattcaggc gacaacctga ctggtgctgg 294601 cgaaggcgac gatgagaatg taaaagtaaa tctcagcgct gtaccggcaa acattgataa 294661 aatctcattt gttattacca ttcacgatgc agaagcgcgc agccaaaact ttggacaagt 294721 atcaaacgcg tttgtccgca tcgtaaatga agaaacaaat gaagagctca tccgttacga 294781 tcttgcagaa gatttctcta ttgaaacggc aatcattgca ggggagcttt acagacataa 294841 cggcgagtgg aaattctcag caatcggctc aggctaccaa ggcggccttg cccgcattgc 294901 aacagactac ggtttgcaag tcggttaaga caaatacgaa gagcagaaag gagagaggca 294961 gtatggccat tcaattatca aaaggacagc gcattgattt aacaaaaaca aatccgggac 295021 tgactaaagc ggtgatcggc ttaggctggg atacaaacaa gtactccggc ggacacgatt 295081 ttgacctgga tgcttcggcc tttttagttg atgcgcatga taactgcgta aatgatctcg 295141 atttcgtctt ctataataac cttgaacatc cgagcggcgg tgtcatccat acgggtgaca 295201 accgcacggg tgagggcgac ggagatgatg agcagattat cgttgatttc tcaaaaatcc 295261 ctgctcacat tgagaaaatc ggcatcacag tgaccattca cgacgctgaa gcacgcagcc 295321 aaaactttgg acaagtttcc aatgcatttg tccgcgttgt ggatgaagaa acgcagaatg 295381 agcttcttcg cttcgatttg ggagaagact tctccattga aacagctgtt gtcgtttgtg 295441 agctttacag acacggcggc gagtggaaat tcaatgcaat cggcagcgga ttttccggcg 295501 ggctggctgc attgtgccgg aattacggtt tgcaagtgta agcgagtgac aaatagagaa 295561 gtcaccgttt caaattatag gaggaaaaaa cttggacttt ttacatcata ttttgtctac 295621 gtatgcttca tttttcgatt ggaaaatgtg gggggaagtt ctgactgatc ctgtttcctg 295681 gggtttgatc ggttcccttg ttgttctgga aggcctttta tcggccgata acgcgcttgt 295741 tcttgcggtc atggttaaac acctgccgga aaaacagcgg aaaaaagcgt taacgtatgg 295801 tttgtttgga gcttatattt tcaggtttat tttcatcggg ctcggtatgc ttctcattaa 295861 attctggtgg atcaaggtgc ttggcgcgct ttacctggct tggctcgtca ttaagcactt 295921 ctggataggc gaaaaagaag aggaagcgga cggcatgaag aaaaactctt ggatggtccg 295981 cacgttcggg atcttctggg cgactgtcat ttcagtagaa ttaatggatc ttgccttctc 296041 tgtggacagc atcctggccg cgtttgcagt atctgaaaaa gtatgggtgc ttctgattgg 296101 cggtatgctt ggtattttaa tgatgcgtac agtggcaaaa gtgttccttg tgctgattga 296161 taaaattcct gagctggaaa acacagcatt cgtcttaatc ggcattatcg cgctgaaaat 296221 ggcggggagc gctttccatt acgaaatgcc gcactctgta ttcttcatta tcattatcgc 296281 tgcatttgcg gtaacattga tcattcacta catcaataaa caaaagcagg tgcgcgaaca 296341 aacagccgct tcaaaagaag aataaaacaa aacaaggagg gaggttcaat gtccttcctt 296401 ttttgttacc gaaatatcgt ttcaatgaca aaccggaaag gaggatatga tgagacaaga 296461 agaactaacc attcataaag cacttccggc tgatggcgat tggaaaagcc tgctgtttca 296521 gccattgccg gagcgggatc actatgaaac tgcacaaggc ctttcttttt ctcgtcttgc 296581 cggtcagata ttgggcacgc ctattgatga gacggactac tataacgagc tgtatgagct 296641 gtctgtaaac gaccgcataa cgattttgag tgaaacgctt gataaaacaa tcgaaccgga 296701 aacatttcaa aagcttcagc atattcattc catcaatcag aaagaaaaag ggctgtcagt 296761 cagccgcttt gttgcctttc tggacgggga aaagctgatt gcgaagcact caaatccctt 296821 gatgcaccgc catttaagaa aagcgttgat gacgctttta catacctttg cggacagtca 296881 tgaaaagggg ctgaatcatc ctgattttcg cagagtgctg cttgatgtct cgaagttttc 296941 cttaaaccat ctgaaccctt ggctggaaaa aaccgatata gagcgggaga tgccgaaggt 297001 tgtttggtat ggagatgcga cgaaaagcca gctctatttc ttatattatc tgatgctggt 297061 cggctgtgat gtactgctgt tccatccggc gggaacggat cagctggcgc ttgtcgaccc 297121 gaagcaggag ctcggtttta cggaaaagct cccggatgtt tcggagcttc agccgtttcc 297181 gaaagaaaaa ccagaccgga aatcaacagt ggcttaccgc tcaacaaagg aaattgaaca 297241 tgtgctgaat cacgaggaat ccatgctata taagccgtgg cagttcagag atcacacacc 297301 ggtgtccgtt acgctgaaaa cgacctatga tgaattgttt ttaatcacga aagaacgcgc 297361 ctttattcgg ccgaatttca aagctgataa acattccatt gagattccga atgtattcgc 297421 caaaattatg ggcgtgtcga aagacaataa ggaatattgg aacaggcttc atactctagc 297481 ggattatcag gaaacagaaa tggtcagaag ctttccattt acagaagaaa taaagtcgaa 297541 ctatcaattt cactacagcc acgcacttga tcaagaaggg aacattgatc cggacaagct 297601 gatggcaagc aatgtgtggc agtacaaaca gctgccggcg ggcgttcaga ctgccattgc 297661 caaaacgatt tcgagaatgt gcaggtaccc gcggcttaaa gccttgcatc aggaacaagt 297721 caaggatgtt caaatctatt tgtttaaaca aacaacaaac ctgcctgcta atctgctgaa 297781 attgattcaa atgttcgact atgcgcaaac cgttccgaaa ctcgttttat atcatacgga 297841 aatgagcggc ggactcacgc gttcggatgc tgccgccctg ctgttcctga atgaaatcgg 297901 aatcgatatc atcatttata atccgcccgg acaccaagat attgagcagt ttattgaaga 297961 ggatcagtat gatatccact ggctggatga catggtgttt cagcaggact acaaagagcc 298021 ttcgcttgtg aaaaggctct tcagaaccat tacccaaaaa taaggagaga agaaaagcat 298081 gacaacagaa aatcaaaatc cgcttgttct cgataaaaat gaagagattt cccagcaaaa 298141 agctgacgat atccgtcttc agctccgtca ggaaccagaa gtgaagcggc ttgctcaaca 298201 aattgacgtc aaaaaccaaa tggagctgct tgagtacggc aaggagccgg ccgttgaaat 298261 atccaagttc tctgaccgca tcttggggat gatgaaaaca acaagcgtga cagactccgg 298321 cacaatgctg actcagcttg ggaaaatcat ggaccgcttc gacaaaaatg attttgatga 298381 gccaaaggga ttaatggcga aaattttcaa acgcggcggc agcatgattg aaaaaatctt 298441 taaaaagtat cagacgcttg gcggagagat tgaaaaaatc cacgttgaga tttcaaaata 298501 caaagatgag atgacgaaga cgaactacac gctcgatgaa atgtatgaaa acaatatcaa 298561 atactatatg gagcttgaaa aatacgtcgt tgccgggcag atgaaactgg aagagatgca 298621 gtcgatcctt ccttcatatg aggaaaaagc ggcaagcggg aaccagctgg cgcaaatgca 298681 gctcgatacg ttgcgcaacg gcattcaggc gcttgaggaa cgggtgtatg atcttgacat 298741 ggcacggatg gtggcgcttc aaaccgcacc tcaaatccgt ctcctgcagc gaggaaatgc 298801 aaagctgatc gggaaaatca actccgcgtt tatcattacc attccgattt tcaaaaacgg 298861 cattattcag gctgttacgg taaagcggca aaagcttgtg gctgattcca tgagcgagct 298921 tgaccgccgg acaaacgaga tgctgaaacg aaatgctgaa aacatctcga gccaaagtgt 298981 tgaaattgcg agaatggccg gcagaccgag catagatatt gaaacgattg aatcgtcttg 299041 gaacacgatt gtcagcggca tgcaggaaac aaaacaaatc gaagaagaaa acaagcgcct 299101 ccgcgaagac ggcgcgagac gaattgccca gcttcaggat aatattaaaa aagcagcatt 299161 gcagcaataa taaaaacccc gcttgtggaa cataagcggg gtatttcaat tacatcattt 299221 agttaatgac aatgtgtaaa gacaggtgta aacttaaacg gtaatcattt tgcatatcag 299281 aggtgttggc aatgggaaaa caacagccta tatcccagcg taaactgctg ggcgtcgccg 299341 gtttggggtg gctgtttgat gcaatggatg tcggaatatt atcgtttatt atcgccgcgc 299401 tccatgtaga gtggaatctg tcgcccgaag aaatgaaatg gatcggaagc gtcaattcca 299461 tcggcatggc tgcgggtgcg tttttgtttg gtttgcttgc tgatcgaatc ggccgcaaaa 299521 aagtgttcat catcaccctt ttatgctttt ccatcggaag cggcatttcc gcttttgtga 299581 cgagcttatc ggcatttcta atccttcgtt tcgtgattgg tatgggactt ggcggcgagc 299641 ttccagtcgc ttcaacactc gtttcggaag cggttgtgcc tgaaaagcgg ggcagagtga 299701 ttgtgctttt ggaaagcttt tgggccgtgg gctggctcgc agcggccttg atttcttact 299761 ttgtgatacc aagcttcggc tggcaggctg cccttctgtt aactgcgctg actgcttttt 299821 atgcgctgta cctgcggacg agtctacctg attcgccgaa atatgaatcg ctttctgcca 299881 aaaagaggtc gatgtgggag aatgtaaaaa gcgtctgggc aagacagtat atacggccga 299941 cggtgatgct gtcgatcgtt tggttctgtg tggtgttttc ttattacggc atgttcctat 300001 ggctcccgag tgtcatgctg ctgaaaggct tcagcatgat tcaaagcttt gaatatgtcc 300061 tgctgatgac gcttgctcag ctacctggct atttctctgc cgcatggctg attgaaaaag 300121 cgggccggaa gtggatactc gtcgtttact tgattggcac agcaggaagc gcctatttct 300181 tcggaacggc ggattcctta agtcttctgc ttacggctgg agtgctgtta tcgtttttca 300241 atctcggtgc gtggggcgtg ctgtatgctt ataccccgga gcaatacccg actgcgattc 300301 gagcaacagg ttcaggaacg acagcagcgt ttggaagaat cggcggcatc ttcgggcctt 300361 tgctcgtcgg aaccctggca gcccgtcata tttcgttttc ggtcatcttt tcaatctttt 300421 gcattgcaat cttacttgcg gttgcttgta ttttgattat ggggaaagaa acgaaacaaa 300481 ctgagctaga ataggaaaag cacctcttaa aagaggtgct ttcagcgtgt cgacaaaccc 300541 tcgcattcgt tgtcaggact gcgcttcggt gctcaatgcg aagtggatca acggctaaat 300601 tctcaggcgt cctgcctaaa cgccgtcgtc atcacatcct gtgaatgtcc gctcctatgc 300661 tcgtccttcc tagacttcaa gggttttcaa tcacgctgaa aagattttgt caacaatctg 300721 aggcacctct tgaatgaggt gcttttttac aattgcgccc gggctgtgga ttggcgtttc 300781 ccggttttac tgattgtctg gtagagcgtc atagaaagta tgaacagaat ggcagtaaat 300841 cctgtgacag ctccgaaatg ctgtgtgctt tgatataaaa aacctgcaat acttgtaccg 300901 acagtggttc cggcatacat agcggcattg gaaagggaag cgatggttcc tcgcgcattt 300961 ggtgcaatgg attgaaagac acccatcatt aacggaaaga tgatgccagc tgtaaagaac 301021 gtgagaaaaa agccggcttc tactaaaaac aagtttggaa agaacggaag agcgaaatag 301081 agagcgccca ttagcagcat cccgctgatc agtgttttaa acatgcccag cttttctgaa 301141 acccggctgc cgataaggct cccgagcata tttcccagtc cgagtacaag catagctgcg 301201 ccaatttgtg acacggttaa atgataatcc gcggaaagcc aagtacccag aaagctgaac 301261 gatgcgaagt ttccggtttg aaacagaaaa taggcaagca gaatgaccga tgttttcggc 301321 aatgaaaaaa gctcccgata ggggttgaca attgatgggc gcgccaatgg ttcagaaggc 301381 cggatgccag gcatgaccgc cgccaggatc aatagaagaa taagcgagca cgctgacaaa 301441 acgaaaaatg gcgtatgcca tgtaaaggaa gcgagaaacc ctccaatagg aagtccgagc 301501 atttgtgaag cggccaaacc tgctgtcgca atccccatgc cttttatgat ctgagaaggc 301561 tggacaatga ctgggatgga cgcccaaatt tgaggcgtca caaacgcagc gctaacgcct 301621 gcggcaaaac ggaacaggca catggcggca aaagagggag cgatgccgca taaaaatgtg 301681 gatacgataa agcctgcaag tccccacagc atgactgttt tcctgttcag ccggtctgag 301741 attgggcctg caatgaaagc gaagagtgca taaccgagtg cataagcact gaccatccag 301801 cctgacaaat cagtagagac atgaaactga tcctgtaaaa gggggagaag cggcgaaagc 301861 aaaaaggtat ccgtgccaat gacaaacatg acactgaaga aaagccaaat gcgattcaaa 301921 ttttatcact cctattgttt tataacttta aaactatgaa acagatatgt atagagaaaa 301981 ccctttgtta gagggtttcc aaaaagccag gcaggtatgt ttgaaatgtg tcttcacgca 302041 gactgacgta ttttgtccgc gaatctttcc gggttgccgt caatcccgct tcacgcagcg 302101 ttttaaaatg ataagatgcc gtggttttga caatattgca cttttcacct acttcaccgc 302161 agctgagttc ttttccgctg acataaagcg tacgaataat ggcaagcctt gattcatcag 302221 acagtgcttt aaaaatttgc gctctgattt gatcatctga ttgtttcata gtcatgaaac 302281 tataatacat aatgggtgtt gaaaaagcaa cttatttttc cagtaaagga gcaggaagtc 302341 ataagaggaa ggaggaattc aattccaata aaagcgtttt caactaaagg taggagaaaa 302401 atcacccgta aaatacaatc atataggagg attacagagc atttagaagc ataaataaga 302461 tcatgtggtc acatggatgt ttataaagaa atggtacaga ataaaagaga atatgctgtt 302521 tgtgtgggaa gttacataaa tgttacggta ataaagattg cttaatatgg agggaaaata 302581 tgagtgtaga tgagaaacca attaagataa aagtcgagaa agtctctaag atttttggga 302641 aacaaacaaa gaaggcagtt caaatgcttg ccaacggaaa gacaaaaaaa gagatcctga 302701 aagcaaccgg atcaaccgtt ggggttaatc aggcagattt tgaagtatat gatggtgaga 302761 tatttgtcat catgggtcta tcagggagcg gtaaatcaac tttagtacgg atgttaaacc 302821 ggcttattga accgactgcc ggaaatattt acattgatgg tgacatgata acaaatatgt 302881 caaaagacca gctccgggaa gtccgccgga aaaaaatcag catggtcttc caaaagttcg 302941 ctctgtttcc gcacagaacg atacttgaaa acacagaata cggactggag cttcaaggtg 303001 tagacaaaca agagcggcag caaaaagcgc ttgagtctct taagctcgtt ggactggaag 303061 gatttgaaca ccaatatccc gaccagcttt ccggcgggat gcagcagcgt gtcggccttg 303121 cccgcgcgtt gacgaatgac ccggacatcc ttctgatgga cgaagcgttc agtgcgctcg 303181 atccactgat tcgtaaagat atgcaggatg agcttcttga tcttcacgat aatgtcggaa 303241 aaacaattat ctttattacg catgacttgg acgaagcgtt gcggatcggc gacagaattg 303301 tcctaatgaa ggacggcaac atcgttcaaa tcggcacgcc tgaagaaatc ctgatgaatc 303361 catctaacga atatgttgag aaattcgtcg aagatgttga tttgtctaaa gtcctcacag 303421 caggccacat tatgaaacgc gctgaaacag tgcggattga taaagggcct cgcgtagcat 303481 tgacactgat gaaaaacctt ggaatttctt caatttatgc agtggataaa caaaagaaat 303541 tattaggtgt tatctatgcg tctgatgcga aaaaagcggc tgagtctgat ttgtcacttc 303601 aagacatctt gaatacagaa tttacgactg taccagagaa tacgtatctg actgagattt 303661 ttgacgttgt gtccgatgcg aatattccaa ttgcggttgt ggatgagaag caaagaatga 303721 aaggaattgt cgtaagaggc gcgctgattg gcgcacttgc cggcaataac gagtatatca 303781 atgctgaagg cactaacgaa caaacacaag atccttctgc acaggaggtg aaataagatg 303841 gatagactgc ctagaatacc tttagcagat attattgacc gttttgttga ctggattacg 303901 atgacgtttg gcggattctt cgacggaatc gctaacggat tggccgcttt tgtaaatgga 303961 attgtcaccg gtcttggatt tattccatct attttgttaa cgattatttt cgccgcactt 304021 gcgtggtgga tcagtacaag gggaattgcg ttatttacgt tgattggatt cctcctgatc 304081 gattatttag gatattggga cccaatgctg caaacattgg cgcttgtttt gacatctgtg 304141 attatttcga ttgtggtcgg ggttccgatc ggaatttggg cgtctcagaa agaaacggtt 304201 cgccgtattg taacgccaat tcttgattta atgcagacaa tgcctgcttt cgtatatcta 304261 ttgccggcga ttttcttctt taacatcggt gttgtgccgg gtgttgttgc atctgttatc 304321 ttcgcgatgc cgccgacaat ccgcatgact gttctcggta ttaaacaagt gccggcggat 304381 ttgattgaag cgactgaggc attcggttct acaacagctc agcgtttgtt taaagttcag 304441 ctcccgcttg cgacaaaaac gattttggcc gggatcaacc agagcatcat gcttgcgtta 304501 tcaatggttg ttatcgccgc aatggtcggt gcaccgggac ttggttctga agtatacagt 304561 gccgttacac agctgaaaac cggggtcgga gtagaggccg gtatcgccat cgttatcgtt 304621 gccattaccc tggaccgtat tactcaaaat attaaagtga agaagaaaag cagggggaat 304681 gcctgatgct taaaaaaatc ataggcatcg gcgtttccgc catgctggcg ctctcacttg 304741 cggcttgcgg ttcagaaaac gatgaaaatg catccgcagc agaacaagtg aataagacca 304801 tcatcgggat tgaccccggt tcagggatta tgtccctgac tgacaaagcg atgaaggatt 304861 atgacctgaa tgactggaca ttgatttcag cgtcaagtgc tgcgatgacc gctacgctta 304921 aaaagtcata cgaccgtaag aaaccgatta tcattacagg atggacaccg cactggatgt 304981 tctccagata taagctgaaa tatctcgatg atccgaaaca atcttatggc agcgcagagg 305041 aaatccatac gatcacacgc aaaggcttca gcaaagagca gccgaatgcc gcaaagcttc 305101 tgagccagtt taaatggacg caggacgaaa tgggcgaaat catgatcaag gtggaagaag 305161 gcgagaaacc tgccaaagtt gctgctgagt acgtcaataa acacaaggat cagattgccg 305221 aatggacaaa aggcgttcaa aaggtgaagg gagacaaaat caaccttgcc tatgtggcgt 305281 gggacagtga gattgcaagt acaaacgtca taggcaaagt cttagaagac ttgggctatg 305341 aggtaacact tactcaggta gaggctgggc cgatgtggac tgcaattgcg acgggaagtg 305401 cggatgcatc cctttccgca tggctgccga atacccataa agcatacgcc gctaaatata 305461 aaggcaaata tgatgatatt ggcaccagta tgactggtgt gaagatgggg cttgttgttc 305521 ctcaatatat gaaaaatgtc aactcaattg aagatttgaa gaagtaatca aaaaagcagc 305581 ctgtgtcagg ctgctttttt tgcgttaaga agcgttagcg gcagcaagtg attccgcctt 305641 ctgaaatgtt ttgagcacgg cgttcgccaa aatatgaatg ccggtaaaca tcgcatttct 305701 gtcaaaggtc atgtgcggat gatggagccc cggctggagc ccgcagccta gtccgagcat 305761 cgttgttttc agattcggca ccttcacggc gtaaaaatgg aaatcctcgc cgccggtggt 305821 gacaagcggg tcatcaagcc gctcagcccc gatgatttcc gtaatggctt ctgccatgat 305881 cgcttcagct tctttatttt gtgttgccgc aggaaggctg tgttctttgt gcagctcgat 305941 ctttgcgcca aatgcagcgg cggccgcttc acaggctctt tctgtttcgg cgattaatgc 306001 ctccatggct tcattggtct gtgcgcgcaa atcaaggctg aacgatgctt ttcctggaat 306061 gatgttagag ctttcaccgc cggcttgcag ttttgtcatt ttgacggtat gcgggatttg 306121 cgggtcaata tgaatgagtc cgagcttgtg tacaagaaat gccgcaattt caatgctgtt 306181 tttcccgagg tgcggacggg cgccatgagc ctcttccccg atgatcgttc cctcaatgtg 306241 ctggcttgat ccgtgcagaa tagaaggagc gcagcggccg ttctgtgttt cctggatcgg 306301 acggacgtga acgccataca aatagtcgat atcatcaagc acgccttctt ctatcatttt 306361 caaggcgccg ccgccttttt cttctgccgg ctgaaagata aaacggattg tgcccttcgg 306421 aagctcaggt tgttttttta gcagcattaa cgtgcccaat gccattgtca tatgtgaatc 306481 gtgtccgcag gaatggttgg cgcgaaatgt gccgttaacc tcctgccaca gcgcgtcaat 306541 atcagcgcgt accgctacaa caggtgagcc tgagccgatt tcgccgacaa ccccggtgca 306601 gtctgaaaac gtgcgcgtcc ggcaccctaa atcctcaagc ttttgtttca aaaatgaagt 306661 tgtctcatat tccttccagc tgacttcagg gttcgcgtgc agatgctcga agatgtccat 306721 aatggtttgt ttcatttctt ctgaaagctt ttgcatggta agaaatacct ccttctatca 306781 gaatgaattt ttaccttctt tactttattt atattgaaac aggaagatag gctgtatata 306841 atatagcaca tattgctact attcagaata attaatattt tcaaacagag gggatggatc 306901 gaaatatgag tatgccagca gccgaaacac agcctaagaa aaaacgtatg acatttaaaa 306961 tgcctgacgc ctatgtcctc ttatttatga ttgctttcat ttgcgcaatc gcttcatata 307021 ttgtgccggc aggtgaattt gaccgcgtga caaaggggga tgtcacgacc gctgttccgg 307081 gaagctatca ttcaattgaa cagtctccgg tcagattgat cagctttttt acttctctac 307141 aggatggaat ggttggatca gcacccatca tctttctgat tttattcaca ggcggcacca 307201 ttgctattct agaaaaaacg ggtgccatca atggcctgat ttacaatgtc atcagcaaat 307261 tccgcacaaa gcaattatta tttatttgta ttgtcggcgc attgttctcc attctcggaa 307321 caaccgggat tgtcgtgaat tcagttatcg gttttatccc catcggcctc attgtggcac 307381 gatccttaaa atgggacgca gtcgcgggag ccgctgttat atacatcggc tgctacgctg 307441 gatttaactc caccatatta tcaccgtcac cgctcggttt atcacaatca atcgcggagc 307501 tccctctttt ctcaggaatc ggcctgcgag ttgtgatata catatgcttt ttgctgtctt 307561 ctattattta tatctatttg tatacgagaa aattaaaaaa atcaaaagat gccagtgtgt 307621 taggaacaga ttggttccct gcggcaggaa tgggcgaagc cggtaaagaa gaagatcagt 307681 cagtgccgtt taccgttcgc cataagctga ttttggctgt ggcgggactc tcacttgtcg 307741 gatttttata cggcgctttg aagcttggct ggtcagattc ccaaatggct gcgacattta 307801 tttttatttc tgtccttgcc ggtttaatag gcgggcttgc ggcgaacgat attgccaaaa 307861 ccttcattac gggctgccaa agtcttgtat acggggcgct gattgtcggg atggcacgaa 307921 gcatttccgt tatccttgaa aatggaaagc ttctcgatac tgtcgtcaat gctttggctt 307981 cacttttgga tggattcagc ccgattgctg gggcaatcgg catgtatatc gccagtgcgc 308041 tgcttcattt tctcatctct tcaggttctg gcgaagccgt tgtatttatt ccaatcctgg 308101 cgccgctcgc tgatttgatg ggaatcacga gacaggttgc ggttgaagcg gttatgcttg 308161 gagaaggggt cgtcaactgt gtgaacccga catccggcgt tctcatggcg gtgcttgccg 308221 ccagcggtat tccgtatgtc aagtggctgc ggtttatggt gccgcttgct ctgatttggt 308281 tcttgatcgg gcttgtcttt atcgtgatcg gagtcatgat caattggggg ccgttttaac 308341 gattgctgcc cgccggcttg tacggcgggc ttttgagtta ttcattgcag aagcgcaggc 308401 tgttattgta acatgtaagc cataagccat tcgtaaaagt gcgggaggaa ggtcatgaat 308461 aatctgcgta atagactttc aggcgtgaat gggaaaaata agagagtaaa agaaaaagaa 308521 caaaaaatct ggtcggagat tgggatgata gcgggagcat ttgcgctgct tgatgtgatc 308581 atccgcggca ttatgtttga atttccgttt aaagaatggg ctgcaagcct tgtgtttttg 308641 ttcatcatta tcttatatta ctgcatcagg gctgcggcat ccggaatgct catgccgaga 308701 atagacacca aagaagaact gcaaaaacgg gtgaagcagc agcgaataga atcaattgcg 308761 gtcgcctttg cggtagtggt gcttacgatg tacgacaggg ggattcccca tacattcttc 308821 gcttggctga aaatgattct tctttttatc gtctgcggcg gcgttctgtt tctgcttcgg 308881 tatgtgattg tgaagctggc ttacagaaga gcggtaaaag aagaaataaa aaagaaatca 308941 tcttttttgt ttggaaagcg agggaagcgt tcacagtttc gggcagcttt ttttatagga 309001 acattgattt gtattcactc tgccaagttg ttttgataga gtgattgtga taattttaaa 309061 tgtaagcgtt aacaaaattc tccagtcttc acatcggttt gaaaggagga agcggaagaa 309121 tgaagtaaga gggatttttg actccgaagt aagtcttcaa aaaatcaaat aaggagtgtc 309181 aagaatgttt gcaaaacgat tcaaaacctc tttactgccg ttattcgctg gatttttatt 309241 gctgtttcat ttggttctgg caggaccggc ggctgcgagt gctgaaacgg cgaacaaatc 309301 gaatgagctt acagcaccgt cgatcaaaag cggaaccatt cttcatgcat ggaattggtc 309361 gttcaatacg ttaaaacaca atatgaagga tattcatgat gcaggatata cagccattca 309421 gacatctccg attaaccaag taaaggaagg gaatcaagga gataaaagca tgtcgaactg 309481 gtactggctg tatcagccga catcgtatca aattggcaac cgttacttag gtactgaaca 309541 agaatttaaa gaaatgtgtg cagccgctga agaatatggc ataaaggtca ttgttgacgc 309601 ggtcatcaat cataccacca gtgattatgc cgcgatttcc aatgaggtta agagtattcc 309661 aaactggaca catggaaaca cacaaattaa aaactggtct gatcgatggg atgtcacgca 309721 gaattcattg ctcgggctgt atgactggaa tacacaaaat acacaagtac agtcctatct 309781 gaaacggttc ttagacaggg cattgaatga cggggcagac ggttttcgat ttgatgccgc 309841 caaacatata gagcttccag atgatggcag ttacggcagt caattttggc cgaatatcac 309901 aaatacatct gcagagttcc aatacggaga aatcctgcag gatagtgcct ccagagatgc 309961 tgcatatgcg aattatatgg atgtgacagc gtctaactat gggcattcca taaggtccgc 310021 tttaaagaat cgtaatctgg gcgtgtcgaa tatctcccac tatgcatctg atgtgtctgc 310081 ggacaagcta gtgacatggg tagagtcgca tgatacgtat gccaatgatg atgaagagtc 310141 gacatggatg agcgatgatg atatccgttt aggctgggcg gtgatagctt ctcgttcagg 310201 cagtacgcct cttttctttt ccagacctga gggaggcgga aatggtgtga ggttcccggg 310261 gaaaagccaa ataggcgatc gcgggagtgc tttatttgaa gatcaggcta tcactgcggt 310321 caatagattt cacaatgtga tggctggaca gcctgaggaa ctctcgaacc cgaatggaaa 310381 caaccagata tttatgaatc agcgcggctc acatggcgtt gtgctggcaa atgcaggttc 310441 atcctctgtc tctatcaata cggcaacaaa attgcctgat ggcaggtatg acaataaagc 310501 tggagcgggt tcatttcaag tgaacgatgg taaactgaca ggcacgatca atgccaggtc 310561 tgtagctgtg ctttatcctg atgatattgc aaaagcgcct catgttttcc ttgagaatta 310621 caaaacaggt gtaacacatt ctttcaatga tcaactgacg attaccttgc gtgcagatgc 310681 gaatacaaca aaagccgttt atcaaatcaa taatggacca gagacggcgt ttaaggatgg 310741 agatcaattc acaatcggaa aaggagatcc atttggcaaa acatacacca tcatgttaaa 310801 aggaacgaac agtgatggtg taacgaggac cgagaaatac agttttgtta aaagagatcc 310861 agcgtcggcc aaaaccatcg gctatcaaaa tccgaatcat tggagccagg taaatgctta 310921 tatctataaa catgatggga gccgagtaat tgaattgacc ggatcttggc ctggaaaacc 310981 aatgactaaa aatgcagacg gaatttacac gctgacgctg cctgcggaca cggatacaac 311041 caacgcaaaa gtgattttta ataatggcag cgcccaagtg cccggtcaga atcagcctgg 311101 ctttgattac gtgctaaatg gtttatataa tgactcgggc ttaagcggtt ctcttcccca 311161 ttgagggcaa ggctagacgg gacttaccga aagaaaccat caatgatggt ttcttttttg 311221 ttcataaatc agacaaaact tttctcttgc aaaagtttgt gaagtgttgc acaatataaa 311281 tgtgaaatac ttcacaaaca aaaagacatc aaagagaaac ataccctgga aggatgatta 311341 atgatgaaca aacatgtaaa taaagtagct ttaatcggag cgggttttgt tggaagcagt 311401 tatgcatttg cgttaattaa ccaaggaatc acagatgagc ttgtggtcat tgatgtaaat 311461 aaagaaaaag caatgggcga tgtgatggat ttaaaccacg gaaaggcgtt tgcgccacaa 311521 ccggtcaaaa catcttacgg aacatatgaa gactgcaagg atgctgatat tgtctgcatt 311581 tgcgccggag caaaccaaaa acctggtgag acacgccttg aattagtaga aaagaacttg 311641 aagattttca aaggcatcgt tagtgaagtc atggcgagcg gatttgacgg cattttctta 311701 gtcgcgacaa atccggttga tatcctgact tacgcaacat ggaaattcag cggcctgcca 311761 aaagagcggg tgattggaag cggcacaaca cttgattctg cgagattccg tttcatgctg 311821 agcgaatact ttggcgcagc gcctcaaaac gtacacgcgc atattatcgg agagcacggc 311881 gacacagagc ttcctgtttg gagccacgcg aatgtcggcg gtgtgccggt cagtgaactc 311941 gttgagaaaa acgatgcgta caaacaagag gagctggacc aaattgtaga tgatgtgaaa 312001 aacgcagctt accatatcat tgagaaaaaa ggcgcgactt attatggggt tgcgatgagt 312061 cttgctcgca ttacaaaagc cattcttcat aatgaaaaca gcatattaac tgtcagcaca 312121 tatttggacg ggcaatacgg tgcagatgac gtgtacatcg gtgtgccggc tgtcgtgaat 312181 cgcggaggga tcgcaggtat cactgagctg aacttaaatg agaaagaaaa agaacagttc 312241 cttcacagcg ccggcgtcct taaaaacatt ttaaaacctc attttgcaga acaaaaagtc 312301 aactaaccgc aactttagag taaagggctg attgtcaatg tgggagcagt tgtatgatcc 312361 gtttggaaac gagtatgtga gcgcacttgt ggcgctcact ccgattctct tttttctttt 312421 ggctttaact gttttgaaaa tgaaaggcat tcttgcggca tttcttaccc tagccgtcag 312481 tttcttcgtc tccgtttggg catttcatat gccggttgaa aaagcgattt cttctgtttt 312541 gttaggaatc gggagcgggc tgtggcccat tggctacatc gtcctgatgg cggtgtggct 312601 gtataaaatc gccgtgaaaa ccgggaaatt taccattatt cggtccagca ttgccggcat 312661 ttcgcctgac caacgattac agctattatt aattggtttt tgttttaacg cgtttttaga 312721 aggcgcggcc ggttttggtg ttccgattgc gattagtgcg gcgctgctcg tcgaacttgg 312781 ttttaaaccg ttaaaagcgg cggcgctctg cttgattgca aacgctgcct ccggagcctt 312841 tggggcgatt gggattcctg tcatcacagg ggcgcagatt ggtgatttgt ctgctcttga 312901 gctgtctcgg acattaatgt ggacactgcc gatgatctca tttttaatac cattcctgct 312961 tgtattctta ttagaccgaa tgaaaggaat caaacagaca tggcccgctc ttctggttgt 313021 gagcggtggg tatacagcgg ttcagacact gacaatggcg gtgctcgggc cggaattagc 313081 aaacattttg gcggccttat tcagcatggg cgggcttgcc ctcttcctcc gcaaatggca 313141 gccgaaagag atttaccgcg aggaaggggc cggcgatgct ggtgagaaaa aggcataccg 313201 tgccgctgac attgcgaaag cgtggtctcc tttctacatt ttaactgcgg cgatcaccat 313261 ctggagcctt cctgccttca aagcgctttt ccaagaaggc gggctgttat atcaatcaac 313321 gctcctgttc aaaatgcctt ttctgcatca gcaaattatg aaaatgccgc cgattgcgcc 313381 atctgccatg ccgttagatg cagtctttaa agttgatctg ctgtcagcga ctggtacagc 313441 gattttagcg gcggtcatcg tgacagggct gttcagcaaa aagttctcct ctcgggatgc 313501 ctttgcttcc ttgaaggaga cgggaaaaga gctgtgggtg ccgattatga cgatctgctt 313561 cgtgatgggg tttgccaatc tggccaactt cgcagggctc agctcttcaa ttgggttagc 313621 attggcgaaa acaggagacc tgttcccgtt tgtcagtcct gttctcggct ggattggcgt 313681 gttcatcacc ggttctgttg tcagcaataa tgctttgttc ggccatttgc aggttgtcac 313741 gggagcgcag atcggtgcgg gttcagattt gctgttagcc gcaaatacgg cgggcggtgt 313801 catggcgaaa cttgtttctc ctcaatctat cgccatcgct gccgcagcgg tcggccaaac 313861 aggcaaggaa tctaaactgt ttaaaaggac agtggcgtac agcctgattc tgttattgat 313921 catttgtata tggacgttta ttcttgcaag attaggagtg taatagaaaa aagcagtaca 313981 tgcccagcat gtactgcttt ttttatgtta atttgctttc tttgtcattt cggctgttgt 314041 tttcactctg gcttttccca taaataaaat ggtaaccgcc gcgaggacaa ttggaatcaa 314101 agcgagcaaa aagacatacg tgatacttga tgacatcgcg tcaataatgc gattcaggat 314161 cgcatcagga atctgggaac gtgttcccgc ttggaatatc tcctgcgggt cgccaatatt 314221 ttgcgcagcg cctgatcccg ctgagccttt cataccgctg aaggcgtcat tcagcttgtt 314281 tgtgaatacg tttgtttgca ccgttccgaa aatggtgaca cctaaggtca tgccaaatga 314341 tcgcaaaaat gaatttgtag agtttgccgt tccccgaaag cgaggttcaa gatcattcat 314401 cgatgccgcc ggcagcaggg agaagttaaa gcctacacca aagcctgaaa tcatcataaa 314461 gactgtcagc catacccgtg ctgtgtcagg cgtcatattg gaaagaagca gcatgccgat 314521 aaagaaagct ataacagata tcagcatcaa attgcggaag cttgccttcg tttggaagat 314581 cccgccgatc atgcttccga tgactgatcc aatcatcatc ggcgtcagaa tgaagcccgc 314641 gcttgtcgcc gagctgccgt agaccgcctg aacgaaaatc ggaataaata ccgctaaaat 314701 aataaatgtt ccgccataca ggaaagcgag aatctgtgct gtggcaaaca agcggttctt 314761 aaacatccag aaagaaataa tcggctcttc tgcttttctc tccacaataa aaaaggcaat 314821 gaagaaaacg gcgaatacaa taaacagccc gatgatctga atggagttcc aatcgtatgt 314881 tttgccgcca agctcaaggg cgaacatcag gcatacaatg gatacgacta aggtaatcgc 314941 gccgccccag tctattttct gctttctgtg ctccagagat tctttgtagt agcgaataat 315001 gaaaaacaat gacaatgcgc cgatcggcac attgatgtaa aacacccagt gccagctgat 315061 cgaatctgta atgatcgcgc ctaagagcgg accaagaaca ctggataatc caaatacagc 315121 accgaacatg ccggacattt ttccgcgttt ttccggcgga aacaaatcaa agataatggt 315181 aaaggcaatc ggcaggagcg cgccgcctcc gatcccttga atggcccgga agatgatcag 315241 ctgattcatc gtctgggcaa tcccgcataa agcagaaccg attaagaaaa aaataagtcc 315301 aaacaggaaa aaacgttttc ggccgtacat atcggaaagc ttgccgtaaa tcggcatgcc 315361 agccataacc gccaccatat aggatgccgt cacccaggca aatttatcga agcttccaag 315421 atcggctacg atattgccca tcgcggtggc aacaatcgta ttgtccattg cagacatcaa 315481 gatgcccagc aggagaccga ggaccacaaa tttggtggaa gcctgttttg ctgttgttgt 315541 gtccatttgt tctacctcct cttacttttc tatgtaagtt ctgatatcat gataatagtt 315601 tgattgttga atatctcgat tatcaagata aactcgattt tatagggagg actgtcagtt 315661 gtcaacaaga aattccagaa gtgagttgga aaagactgct gttcagcttt ttcgaaaact 315721 gggcacaaga acggttctgt ttcatcaggc agccgctcaa gctctcggtc tgtttcccac 315781 cgatttgaaa tcagctgaca ttttaaatga agcagggccg atgacggccg gagagctggg 315841 gaaaaaaacc ggcctcagca cgggttccgt cacggcgctt gttgaccggc tggaaaaagc 315901 ggggtatgtg gctcgtgaaa aggacccgaa cgatcgcagg agagtcgtaa tcgtcccttt 315961 gactgcttcg aaaaaacata taaaggattt gttccgtcct ctgtctgagt caacgatgga 316021 tttgtgccgc gaatatacgg aagaggagct ggaactcatt ttcagttttg taggcaaagc 316081 tgccgatatt atggaggaag agcttgaacg tctgaaacag taagtgaatt tgtgcatagc 316141 ttggcccgtt cccgaataaa ttgtacaagt tacataagag aagggagtac gggccggtga 316201 acattttttt gagctatatt gtgctgggac tgtccttgtc tgcgcctgtg gggccagtga 316261 atgcggcgca aatagacaaa ggaattaaaa acggtttttg gcatgcatgg attttcggtt 316321 taggcgccat gacagcggat gggctgtaca tgctttttat ctatttcggg ctgtcgcagt 316381 tcttgaccgc tccatttgtg aaaacgtttt tgtggctgtt cggctttttt gtcctgacct 316441 ataccggaat tgaaacgctg aaaaacgtca gagaaccgat ggatgtgcga agctcgcggg 316501 ggaaaccgtc atacaggaaa acattcgcat cgggttttct catttcattg tcaaacccat 316561 tgagcatcct tttttggctt ggaatttacg gaagcattct tgcgaaaaca gcagaggcct 316621 acaatatgaa tcagcttcta atctatagct ccggcatcat gatcggcatt ttaatctggg 316681 atttctgcat ggctatcaca gccagtacgt tcagaaacct gcttcatgaa aagctattga 316741 gaggattgac cggaatcgcc ggtgtatccc tccttgtgtt tggcttttac tttggttatc 316801 agggcatcaa acagttattg ggctgattca tgaaggacag tcacctgccg cttccagttt 316861 taatatagta tccagatgat actggaggtg gatcaatggt gaatgggatt tacaccaaaa 316921 gttttctgga acgtattcag gaagagcttc ctgaatggca aagaatcgct tttgagctgc 316981 tggcagaaac tctgggggac gacgcggata catttccgtg cattcccgga cgccaggcgt 317041 ttctgactga tcagcttcgg attgcttttg ccggagatcc gcgggaaaac cgcacagcgg 317101 aggaactggc tccgttgctt gcggagtacg gcaagatatc gcgggacacg ggaaaatacg 317161 catccctcgt tgtgttgttt gatacaccgg aagatttggc ggagcattat tcgattgaag 317221 cgtatgaaga gctgttttgg cgctttttaa atagactgag tcatcaagac gaaaaagaat 317281 ggccggaaga cattccggcc gatcctgagc attataaatg ggagttttgt tttgacggcg 317341 agccgtattt cattctgtgc gctacaccgg ggcacgaggc aagaagaagc cggagctttc 317401 ctttttttat ggtcacgttt cagccaaggt gggtgtttga tgacctaaat ggatcaactg 317461 catttggccg taacatgagc aggctgatcc gatctcgttt agaggcctat gatcaggctc 317521 cgattcaccc gcaattaggc tggtacggag gaaaagataa tcgtgaatgg aagcagtatt 317581 tcctccgtga tgacgaaaaa caggtatcga agtgcccgtt ttcttattta aagaacatgt 317641 tcaacaaaat gaaataaatc aaggactggc agggcgatct ttatgaccct gctttttttg 317701 atagatcatg gtaacgatgg cgataatcac gagaaaacct atgctgacga aaaaaccggg 317761 ccggcttgat ttttcaaaca atgtaccgga cacagctgca gcaatcagaa ccatcgctaa 317821 ataaatttgc gtttttccca tgccctcggg atcagtcagc tttttgctgg agaacaggat 317881 aaacagccaa gtgtataaaa gcataagccc cgcagctgtt gtcatatgct cataaatgtt 317941 tttaggcagc actaacgaca aaataatgga gaggacaagc cccgcaaacg tcagcccaag 318001 tgccggccag catatttttt tgccttcctt tagagtaaag catttcggcg cgtcgccgtc 318061 atcagccatt gtacaaagca atgtcgtaac cgcaaatagc gaagcgacaa gggtcgagaa 318121 ccctgcgatg atgaaaatcc cgttaaatat atcaaggatg atctcaaggt tatatccttt 318181 taatgacgta atgaacggac tgtcctgttc agtaaacgtg tgtaacggaa ccaaaagcag 318241 agcaagcccg attgaaatga tataaataat cgccagcgtc gccagcatca gtttccctga 318301 tttagacgct tcctcaggtt tttttaagtg aaccgccatc agccccatga cctcaattcc 318361 gccaaaagcg taaaacgcgt agattaaacc tgtccacagc cccatggcgc cgtatgggaa 318421 aaactcactc gtcttatttg gaacatgtat gccatgattt ccgccggaca ggataccgca 318481 taaagccagg atggcaatga caataaacat aaaaatagca gctgttttaa tgactgccag 318541 cacgttttct gttttttcaa agacggacag gccggtgaaa ataataagga gcccaagtac 318601 tgcgtagatt gaggcaaaca cccatagcgg cacttgagga aaccaatgct tcgtaaagag 318661 cgaaatggct gtcagctggc ttccggtaat cagcatttct gatgtccagt acacccagcc 318721 gttgctgaag cctgcccatt tgccgaatgc ttttcgggca tacgcacaaa acgagccctt 318781 ttccggctgc ttcgccgata gcttggcgag ctgttcaaag acaaaatacg taccgatccc 318841 tgcgatcaga aatgaaagga gaacggaaaa accgcttttt acaattgcga tgctggaacc 318901 gagaaagaag cctgttccaa tcgtgcagcc gactccgatc agtgacagct gccaccaagc 318961 cagattccct tttggctggt ctttttttgt ttggctcatt atttattcaa ccccttttat 319021 ctaaggttag attgtgatct gtccaaagct tatatacatc ggatttttgc ctctttttac 319081 atggagaagg aagcagacgc tcatactaat gaaaaaagga gcaaaccaat gacacagcaa 319141 tatattgtgg agccgaaaaa agggcttggg ctgaagctga aaaaggggca gattttaaag 319201 gtggttgatg tagaagggca gcaggtggct gattttgtcg cataccatgc caaggatttt 319261 tatgaacacc ttgatcaggg agcgacgata gacgccaatc actccattca tgtgaaggtc 319321 aacgaccatc tctactccaa cctgtataag ccgatgttaa ccctgattga agatacggtc 319381 ggcaagcatg atctgctgtt gcccgcctgc cgtcctgata tgaacaggct cttatatggg 319441 aagcaaaagg atgagtttca ggatacgtgc tatgacaata tgaaccgtgc gcttgagcag 319501 tttggcgtac cgaagcccca catgcattac ccatttgcga tttttatgaa tactgtcctt 319561 gatgagaaag ggaatctgtc tgtggaaacg ccgctttcga atgccggaga ttatgtaagg 319621 ctcagggcgg agatggattt aattgtcgcg ttttcttcct gcccgattga aaaagggaaa 319681 tgcaatggcg acagtgtgac atccatacgg gttgaagtca gctgatctct cttgttcaca 319741 gtgaatgaag acctgtgcta tatttaatag ggatacataa cagtcatgat tcattttcat 319801 tgatttaggg aaatgatcag taataaggga aaatgtacag gaggaatgat tgggatgagc 319861 atgcaggaaa agattatgcg tgagttacat gtgaagccct caattgatcc aaagcaagaa 319921 attgaggacc gagtcaattt tttaaaacaa tatgtaaaga aaaccggtgc taaaggcttt 319981 gtattgggaa tcagcggggg ccaggattca acacttgcgg gaagactcgc tcagcttgcg 320041 gtggagagca ttcgcgagga gggcggagac gctcaattta tcgcggtccg tcttccgcat 320101 ggcacacagc aggatgaaga cgatgcccag cttgctttga agtttattaa gccggataaa 320161 tcatggaagt ttgatattaa atcgacagtc agcgcttttt ctgatcagta tcagcaggaa 320221 acaggcgatc agctgacgga ctttaataaa ggaaacgtaa aagcaagaac aagaatgatc 320281 gcgcaatacg cgatcggcgg ccaggaaggt cttcttgtgt taggaacaga ccatgctgct 320341 gaagcagtga ctggtttctt tacgaagtac ggtgacggcg gagcagacct cctgccgctg 320401 acaggcttga cgaagcgcca gggaagaacc ttgctgaaag agctgggtgc accggaacgc 320461 ttatacttaa aagaaccgac tgccgatctg ctcgacgaaa aaccgcagca gtcggatgaa 320521 acagagcttg gcatttccta cgacgagatt gacgattatc tcgaaggaaa agaagtatca 320581 gcgaaagtat cagaagcgct ggaaaaacgc tacagcatga ctgaacataa acgccaggtt 320641 ccggcgtcta tgtttgatga ctggtggaaa taagttgaag aaagcccgct ctcggagcgg 320701 gcttttgtcg tgtacagaag ctttatttga tgcggatatg attcagcttt accattaatc 320761 tgtcggcgaa ccttcggagg ctgcctcttg tatcaggatc taatgggagt tcggctctcg 320821 cggcaatgtt ctctgccaca tcctgaatcg acaggttgtc tgtttgaatg tggtcctcaa 320881 aaatgggtga tgataatcct tcaacacagc ggtcaatttg tttggcggcc catgagtttt 320941 ttccttctgc tctggtgcgc agccttttta acaaggtttc ctttgaagcc attagtgtaa 321001 agtggtgaac gatcctgcct tcctgtctga gcctgccgat gatctcattg aagtattcag 321061 ggtgtacaat cgtcataggc acaataagga tgccgcggta tgtatctgtc agagaagcta 321121 gcaaactgta attgaacgcc cgccataaag gatagctttg aaaatcgtcc tttgcgatct 321181 cctgcggcac catggagcgc agcgcaaaac ccattttctc gggatcatac acgtaagatg 321241 ggttcagcct tctgtgcagt tcgaaggctg tttgtgtttt tcccgaaccg aatgccccgt 321301 ttatccaaat gatcatcgcc atttctccct tcctatttat catacagaaa aagacccttc 321361 catcgaagag tcagctggaa aaacaataaa ggcggaaggt tttaacgctt ttttgcgtcg 321421 aagtattaaa atacctgcag aaatgttgta caatgaatgt cattcaggca aaaatggcta 321481 caacaaagcg cactataagc ttgaccggta aagccggtat ctatataaat attcgctaaa 321541 taagcatata atgaatatat aatttcattc cttaggagga tttcgccgaa gatgaacgct 321601 aaacgagcca tcccagtaag agaaagaaat atcgtcctga tcggattcat gggtgtagga 321661 aaaacaacaa tcggccaatt ggtcgctaaa aaattatata gagattttat tgatattgac 321721 cagcagatcg aaaaggattt caatatgtca attcctgaga tatttgagaa aaagggagaa 321781 gactttttcc ggaaaacgga gaaggaatat attttagaca tctgccatca taaacgattc 321841 aaaatcgtat ctctgggcgg gggatctttt aaacaagaag aaatcagaaa ttgctgtctg 321901 gaaaactgtc tcgtgcttca tctggacctg tcatgggaga actggaagca gcgcgcggat 321961 ttattgatcg aaagccgccc tgtactgcat aaccgttcaa tggatgaaat ggaacagctg 322021 tttaacgaaa gaaaagtcat ttatgacaag cacaattcaa aagtggcaac agacaacctt 322081 tccccggaag aggttgccga ttacattgtt gagacattaa aaattggctg ggatctttat 322141 cagccgatgt aaaaagccgt gcgcagcgca cggctttttt tatcgtttta tcccttgtat 322201 caaaatcgct tttaaacaaa aggagatggg ctgtccgttt tggttcaatg taatacagaa 322261 cgtgtcgcgt gcttcgtctg atgcgtgatt caagtgggta atgatttgtt tttctcggtc 322321 agcgggggtt ccgcctcgtt tgatccagct atcgtattga atcggcaagt tccacttttg 322381 gatgtcttga taggccagtt gattggcgct gaacatcgcc tgccattctg ataatgagct 322441 ttcacgaaca tgggaagggt ctcgaagccg gttcaaatga ttgacaaact catcaagaac 322501 gggatcttca ggcgcgtaat gatcaactaa gagaaaacgt ccgtcctgtt ttagtacgcg 322561 tgcaacctct ctgacagctt tgcggacatc tgaaaaatgg tgggctgcgt atcggcaggt 322621 gatgatgtca aatgaatcgt cggggaaggg gagtgactct gccgttcctt gctgaaagcg 322681 tacgttttca actccttttt cttgcgcgaa ggaggacgca acctcaacca tctctttcgt 322741 tgcatcaaca ccgatgcact cctgtacata aggagaaaat gccagcgccg tatggccggc 322801 gcccgctcct atatccagca ctcgatgctc tgcccggcat tccgctgttt tgatcatcaa 322861 ccccaaatct tccccctcgg caaatacctt ttcatcccga tacatctcgg cgtttttaga 322921 aaacggtgtt tcatttgtca tttgaaccag ctccttcttt tcgtaaatga tgatatggat 322981 tatgttagca atttctgtta tgattcgtcc aagatataaa aatgatgaaa atgataggtt 323041 caacctatgg aggctgaaat ggatattaaa gtgatggaat atgcagcgga aattgcccgg 323101 cgccaaagct ttacaaaggc ggcggaacat cttcatatcg cacagccgtc tctcagccag 323161 caaatcaaaa agcttgaggc tgagctgggg cttacccttt ttcacagatc ccatggctct 323221 gttacactga cacctcacgg caggcgtttc attgaaaaag ccgaggacat cattcgttcc 323281 agagatgatt tgcttcggga aatgcaggag cgatcacagg gaatcggtca taaattatcc 323341 atcgggattc ctgctgtaac agggagatat ctctttcctc cgctgctgaa gcagtttttg 323401 gcgcgctatc ctcatgtgga ggttcagctt gttgaaaaag atccggtttc attagagaag 323461 atgacggcaa agggagaagt tgacctttct gttttatcct tgcccatcga ggatgaacgg 323521 ctctccatta cacccttgct cacggaaccg gttgttctcg cggtgccgaa ggaaaaacaa 323581 aggtggatgc cgccggaatt ggtcgcgctg attgagaaag cgctggaaga agatgaggga 323641 cgccagccgt gtgtgccgat tgacatggta aggaacgtgc cctttattct gttaaaagaa 323701 ggcttcggct ttcgcaggac agttctcgat ctctgtgcgg aaagcggctt taagccgaat 323761 gctgccttta agacgagcca tattgaaacc gcccaatctc ttgtggctaa cggattaggt 323821 gtgacaatgg caccgaatat ggtcagaagg gataaagatc cgggtgtgat ctatttatcg 323881 attcaatccg cgccatcacg aaccctcgtc tttgtctttt taaagaaccg ctatgtcagt 323941 ctgacggccc aggcctttat ggaactaagc cgggaaagtc ttaaacaaac gtttgatgaa 324001 ggctgtctgg gaaacaaaga tgaaaatatt tagaaaacaa agacgaaacg tggtagtata 324061 ggaatacaaa ctaaatctta taaaacaaag gggaataatc ggaaatgcaa ctattcgatc 324121 tgccgctcga ccaattgcaa acatataagc ctgaaaaaac agcaccgaaa gatttttctg 324181 agttttggaa attgtctttg gaggaacttg caaaagtcca agcagaacct gatttacagc 324241 cggttgacta tcctgctgac ggagtaaaag tgtaccgtct cacatataaa agcttcggaa 324301 acgcccgcat taccggatgg tacgcggtgc ctgacaagga aggcccgcat ccggcgatcg 324361 tgaaatatca tggctacaat gcaagctatg atggtgagat tcatgaaatg gtaaactggg 324421 cactccatgg ctacgccaca ttcggcatgc ttgtccgcgg ccagcagagc agcgaggata 324481 cgagtatttc accgcacggt cacgctttgg gctggatgac gaaaggaatt cttgataaag 324541 atacatacta ttaccgcggt gtttatttgg acgccgtccg cgcgcttgag gtcatcagca 324601 gcttcgacga ggttgacgaa acaaggatcg gtgtgacagg aggaagccaa ggcggaggtt 324661 taaccattgc cgcagcagcg ctgtcagaca ttccaaaagc cgcggttgcc gattatcctt 324721 atttaagcaa cttcgaacgg gccattgatg tggcgcttga acagccgtac cttgaaatca 324781 attccttctt cagaagaaat ggcagcccgg aaacagaagt gcaggcgatg aagacacttt 324841 catatttcga tattatgaat ctcgctgacc gagtgaaggt gcctgtcctg atgtcaatcg 324901 gcctgattga caaggtcacg ccgccgtcca ccgtgtttgc cgcctacaat catttggaaa 324961 caaagaaaga gctgaaggtg taccgctact tcggacatga gtatatccct gcttttcaaa 325021 ctgaaaaact tgctttcttt aagcagcatc ttaaaggctg ataaatgtga aaagccgccg 325081 catatcatca ggcggttttt ttctgcaaac tgccggaatg agaacagact ggagacgaat 325141 agatatgaaa caaagaatca ttgatgaatt aaaacggatc gagcagtcat acggagtcaa 325201 aatcgtgtat gccgtcgagt caggaagccg cgcatgggga tttccctcgc aggatagtga 325261 ttacgacgtc cgctttattt atgttccgaa aaaggagtgg tacttttcaa ttgagcagga 325321 gcgtgatgtc attgaggaac cgattcacga tttgctggat atcagcggct gggagctgag 325381 aaaaacgctt cggcttttca aaaagtcaaa ccctccgcta ctcgaatggc tgtcctcaga 325441 cattgtgtat tatgaagcat ttacgaccgc agagcagtta agaaaactcc gcacggaggc 325501 atttaagcct gaagcaagcg tgtatcacta tatcaatatg gcgagaagga acgtcaagga 325561 ttatctacaa ggacaagagg tcaaaattaa aaagtacttc tacgttcttc ggcctatttt 325621 ggcctgccaa tggattgaaa agcacggaac cataccgcca atggacttta ctgttttgat 325681 gaatgaactt gttgctgaac ccgagctgaa ggctgaaatg gaaaccttgc ttgaacggaa 325741 aagaagaggg gaagagcttg acctcgaagc aagaatcgat gttattcacc aattcattga 325801 aacggaaatc gaaagaatca tggaagcggc aaaagaactg aaggcagaga aaaaagatat 325861 gacatctgaa ttgaaccgtt tgcttttgaa tacggttgaa gaagtgtgga aggatggagg 325921 aagctgatgt tttttgtcgc ttccttttct cctttattcg acagaatccc cccccgactt 325981 tctaactatc tgattgtggc aaacccacaa aaataatcag aatctttgta ttttgagaat 326041 attgtgaacg ctggttttgt ccatttacaa taaactcata caaatacttc ttagattgcg 326101 gggtgttgag gttggaagtg atcacaagag attttttctt atttttatcc aaaagcggct 326161 ttctcaataa aatggcgagg aactggggaa gtcgggtagc agcgggtaaa attatcggcg 326221 ggaatgactt taacagttca atcccgacca ttcgacagct taacagccaa ggcttgtcag 326281 ttactgtcga tcatttaggc gagtttgtga acagcgccga ggtcgcacgg gagcgtacgg 326341 aagagtgcat tcaaaccatt gcgaccatcg cggatcagga gctgaactca cacgtttctt 326401 taaaaatgac gtctttaggt ttggatatag atatggattt ggtgtatgaa aatatgacaa 326461 aaatccttca gacggccgag aaacataaaa tcatggtcac cattgacatg gaggacgaag 326521 tcagatgcca gaaaacgctt gatattttca aagatttcag aaagaaatac gagcatgtga 326581 gcacagtgct gcaagcctat ctgtaccgga cggaaaaaga cattgacgat ttggattctt 326641 taaacccgtt ccttcgcctt gtaaaaggag cttataaaga atcagaaaaa gtagctttcc 326701 cggagaaaag cgatgtcgat gaaaattaca aaaaaatcat ccgaaagcag ctcttaaacg 326761 gtcactatac agcgattgcc acacatgacg acaaaatgat cgactttaca aagcagcttg 326821 ccaaggaaca tggcattgcc aatgacaagt ttgaatttca gatgctgtac ggcatgcggt 326881 cgcaaaccca gctcagcctc gtaaaagaag gttataacat gagagtctac ctgccatacg 326941 gcgaggattg gtacggctac tttatgagac gccttgcaga acgtccgtca aacattgcat 327001 ttgctttcaa aggaatgaca aagaagtaaa aaaggagaga ttatcatgac aacaccttac 327061 aaacacgagc cattcacaaa tttccaagat caaaacaacg tggaagcgtt taaaaaagcg 327121 cttgcgacag taagcgaata tttaggaaaa gactatccgc ttgtcattaa cggcgagaga 327181 gtggaaacgg aagcgaaaat cgtttcaatc aacccagctg ataaagaaga agtcgtcggc 327241 cgagtgtcaa aagcgtctca agagcacgct gagcaagcga ttcaagcggc tgcaaaagca 327301 tttgaagagt ggagatacac gtctcctgaa gagagagcgg ctgtcctgtt ccgcgctgct 327361 gccaaagtcc gcagaagaaa acatgaattc tcagctttgc ttgtgaaaga agcaggaaag 327421 ccttggaacg aggcggatgc cgatacggct gaagcgattg acttcatgga gtattatgca 327481 cgccaaatga tcgaactggc aaaaggcaaa ccggtcaaca gccgtgaagg cgagaaaaac 327541 caatatgtat acacgccgac tggagtgaca gtcgttatcc cgccttggaa cttcttgttt 327601 gcgatcatgg caggcacaac agtggcgccg atcgttactg gaaacacagt ggttctgaaa 327661 cctgcgagtg ctacacctgt tattgcagca aaatttgttg aggtgcttga agagtccgga 327721 ttgccaaaag gcgtagtcaa ctttgttccg ggaagcggag cggaagtagg cgactatctt 327781 gttgaccatc cgaaaacaag ccttatcaca tttacgggat caagagaagt tggtacgaga 327841 attttcgaac gcgcggcgaa ggttcagccg ggccagcagc atttaaagcg tgtcatcgct 327901 gaaatgggcg gtaaagatac ggttgttgtt gatgaggatg cggacattga attagcggct 327961 caatcgatct ttacttcagc attcggcttt gcgggacaaa aatgctctgc aggttcacgt 328021 gcagtagttc atgaaaaagt gtatgatcaa gtattagagc gtgtcattga aattacggaa 328081 tcaaaagtaa cagctaaacc tgacagtgca gatgtttata tgggacctgt cattgaccaa 328141 ggttcttatg ataaaattat gagctatatt gagatcggaa aacaggaagg gcgtttagta 328201 agcggcggta ctggtgatga ttcgaaagga tacttcatca aaccgacgat cttcgctgac 328261 cttgatccga aagcaagact catgcaggaa gaaattttcg gacctgtcgt tgcattttgt 328321 aaagtgtcag actttgatga agctttagaa gtggcaaaca atactgaata tggtttgaca 328381 ggcgcggtta tcacaaacaa ccgcaagcac atcgagcgtg cgaaacagga attccatgtc 328441 ggaaacctat acttcaaccg caactgtaca ggtgctatcg tcggctacca tccgtttggc 328501 ggcttcaaaa tgtcgggaac ggattcaaaa gcaggcgggc cggattactt ggctctgcat 328561 atgcaagcaa aaacaatcag tgaaatgttc taagcgggac taaatgggca tcctccctgc 328621 gggggtgtcc atttcatcca tatactataa aaaagaggag gaagtgccat agaaaacaca 328681 cagctgatta tttcgatttg tatttatatg gcgggaatgc tgctaatcgg ctactttgct 328741 tacaagcgta cgtcgaatct gacggattat atgctgggag gacgctcttt gggtccggca 328801 gtaaccgctc tcagtgccgg cgctgccgat atgagcggct ggctgctaat ggggcttccg 328861 ggcgccatgt tttctactgg tctgagcggc gcttggatcg tcatcggact ttgccttgga 328921 gcgtgggcga actggcttta cgtcgcacca cggctgagaa cctatactga aaaagcgggg 328981 aattctatta caattcccgg attcctggaa aatcgcttcg gagatcaaac aaagcttctc 329041 agactgtttt cgggaattgt cattttagtc tttttcacgt tttatgtatc gtccggaatg 329101 gtgtccggcg gcgtcttatt caacagcatc ttggggatgg attatcacac cggcctgtgg 329161 attgtgacgg gtgttgttgt ggcatatacc ctgtttggcg gctttttggc agtcagctgg 329221 acagattttg ttcaggggat tattatgttt gccgcactca ttcttgtgcc gatcgttacg 329281 tttttccaca cgggaggagc aggtgataca gttgctgaaa tccgctctgt agatcctgat 329341 atgtttaata ttttcaaagg aacgagcgtc cttggcatta tttctttgtt tgcctggggg 329401 ctgggatact ttggccagcc gcatattatt gtgcgtttta tggcgataac gtctgtcaaa 329461 gagatcaaaa gagcgcgcag aattgggatg ggctggatga ttttgtctgc agtaggcgca 329521 gtgctgaccg gtttgggcgg aatcgcttat taccatcagc gcggcatgac actgaaggac 329581 ccagagacga tttttattca attagggaat atcttgttcc atccgattat cacgggtttt 329641 ctgatttcag cgattttggc cgcgattatg agtacaattt cttcccagct gcttgtgaca 329701 tcaagctctc tggtagaaga tttgtataag tcgatgttca gacgctcagc ttcagataaa 329761 gaactggtgt ttttaggccg actggctgtt ctggctgttt caattgtcgc gttggttctg 329821 gcttgggaga aaaataacac catccttgga ttggtcagct acgcgtgggc gggcttcggt 329881 gcatcattcg ggccagttgt actgctcagt ctgttttgga aacgaatgac caaatggggg 329941 gcactcgccg gcatgattgt gggagcagcg actgtaatca tttgggcgaa tgccggtctt 330001 tcggactttc tgtatgaaat gatacctggt tttgctgcga gtctattatc tgtctttttt 330061 gtcagcatat tgacgcaggc tccgtcacaa gctgtcacag accagttcaa cgactaccaa 330121 gatacaatgt cgcaataaag atcgaaagga ggaggaaggg gctgtccctt tttcctcttt 330181 tctcctttta agcggccatt tttttctttt ggaaacaaac gtattttttt ctatacaaaa 330241 agaccccgta tggatatgat taaagtaaaa aaagtatagg agaaaaaggt atggaagagc 330301 ttttagagag agttttttca ttttcagatg ttgataagct aattgatttt attagctatg 330361 aactgcaaaa gccagtgata ctggaaagcg cggatttctt tttgttagcc tataattctt 330421 actatattaa ccattttgat tctgccaacc agcagactat tttttcgaaa aagtgtccgg 330481 tccagatttt tgagaggttt ctgaaggacg gaattattga aaaattgaaa acagagcctg 330541 agccttttcg cgtcaataaa attgaaagca ttgggttaaa ccagagggtg gtcgtgagtg 330601 caaagcacaa aggggaagtc atgggctaca tctggattca ggagctggac caaaatctga 330661 cggatgaaga gctcgacttt ttgtacgaga cctccttcca tgtcgggaaa atcatttata 330721 aaacgaataa attgaaacag gaaaaggaag aaaaagcaga ggatctcatc aaacgggcga 330781 tctatcagca atttacctct gagaaggaac tcagacggga agctgaaagg atcaacaccg 330841 tgctgccttc catgttttca gttgttatcc tgcacgccgc aaatggggat ggggaagcgg 330901 ttgaggattt aaaggaaaat atcaggtcgt acctgaattt acgggataag gtcagtcatg 330961 tcttaacgat cgaatcaaac attgtcatcg tcgtagcgag tttttcccaa aaaagctccg 331021 tctcctcagc agcttctgag tttattaaca agctgttaac acattttcac tttcaaaaaa 331081 tacctacccc tatttatatc ggtatcggaa acgaatataa tcacctatta aaacttggca 331141 agagctacac agaagcactt gaagtcatca aagccgcaga aatcaccggc aatcaggaaa 331201 acattccata tgaatatgcc aaactcggca tttaccgcta tttagaaagc atcgaacaga 331261 aaaatgaatt tttagaatac gagaataaag atttagcttt attaaaagca aaagacgaag 331321 aaagcagcac tgagctgctc aaaaccttgg aaatctatct cctcaacaac tgcaaaacaa 331381 aaccagcggc agaacagctg tttattcacc aaaatacatt gaattaccgc atcaaacaga 331441 ttactgagat gacgtcgatc gatttaagcg atttcagaac gcggtgccag ctctatctcg 331501 atttgatgct gatgaaaaag aaataaaaaa gaaaccagta cttgtactgg tttcgtcttc 331561 acttaaaatc ctctgtaaac atacggatca tcaggttttt taatggtatt ccagtcagtt 331621 actttgacga cagggagagt tgacttgaat ggctggtaat attctgaggc cagagtgccc 331681 ttaatgtgaa tccattcatc atccttgatg tccatgtcct tcggaaattc cacaagcatc 331741 ccgtacacgc cggaatcagc gatacagtga atgatgccaa accttaatac gaacagctga 331801 tttttgttaa ttgcgtttcc tttgtaagca aatccatgaa attctatcgt ccgtccgaga 331861 aattcacccg gatagttata gatggtttcc attcctttta ggaaatcgtc atcggtcaga 331921 gaaatctctt ttttgctgga atacttatta aacagctgtt tcatttgttt gtcatagctg 331981 tcttgcgcgt aataaaggct ggcatcaggc cgcaaatact gtgtttggga gtagtgatct 332041 ccgctctcca tcgccttaaa cgagaaccct tttgttttga ctatggatga gtcaagcgtt 332101 gcaatcggga agaagatgcc tgacaccaaa ggaaaaagaa aaacaacata aatcaaataa 332161 cgctgataaa atggcttgtt ttgttcatgg tcatgctcgt gatcatggcc gcacccgcaa 332221 tcatggtcat ggtgatgtcc gcttttttca ggcgacttga taaatagata tgcttggacg 332281 gcggtcagaa tggccagcag gaagatcgca ataaaggaaa gataggcata tttcatattg 332341 atatattttg ttagatttcc tgaggcatgc agatgataaa agaaaaacgt aaatcccatc 332401 agcaccaata aacgaaacat ccaatcaccc ctttaccagt agtgatcccg ctaaaacaat 332461 cacgacaatg tatgtaatca gcaggaaaac aaatcgtttt ttgaaggccg caagcatcat 332521 caatagattc ttaatatcca ccattgcacc aaagacgaga aaggcgatta acgatcctaa 332581 tgaaaacgtg ctgctgaagg aagacgcgat gaacgcatca acttctgaac aaagcgacag 332641 gacaaacgcc agacccatca tcacgaggga agaggataca tcattctgcc cgatcgcaag 332701 cagagtggat gttttgacat acgtctgcat agcggctgcg ataaaggcgc cgatgattaa 332761 atatttcccc acggagaaaa attcatcaat ggcatgccgc aaggtcccgc ccagtttttg 332821 gagcaaggtg ccgtgatgat gatggtggtg cccgggttca tcaggcttta aaagctggtt 332881 atccttaaat tgataggata agatgacccc gatgatcagc gaaacggcga gagccagtcc 332941 gcctctgtaa aagaccacgc tccatctatt cccgaacgca atataagtag aaaataaaac 333001 gataggatta atgataggcg cggtcagcat gaaagcaacg cccgcatgca gaggaactcc 333061 ctttaacaga agccgcctcg taatcgggat gatgccgcat tcgcaggcgg gaaataaaac 333121 gccggccagc gcaccgaata aaacggcgag aaaacggttt ttcggcatga ttcttgcaat 333181 catttcttca gaaacaaaca tttgaatgat tccggaaagt atgacgccaa tcagaataaa 333241 cggaatggct tctattaaaa tgctgataaa aatagaattc agctgaagaa aagatgattg 333301 tgctgtcaca ataaaacctc cgctcatgtt aagctgcctt tcttatgata ccagaaaaaa 333361 aggcactgct tgtttgacgg aggaggggaa aggatcgttt cactttggtt aggattccaa 333421 aaagccgagt aggatactgc ctgtttctgc agcttctttt ccgagccaaa tcaggtgtcc 333481 ccatgagtga agcaaacaga gaacagcgcc acgaatgtgc tcttttgcat gatgtgcatg 333541 tgacaagtca accaatccgt cataaacact ttgcataatc agcacgggac atatgatggc 333601 ttgcaggtct tttaaagaga cagcggcggt ttgtgacaag tcaatcagaa atccttcacc 333661 cgagcgctgc cggctgttca ttttccgaaa tgcttctatg tctttttcat tcatcaagga 333721 cttgattcgc tgaaacggaa gcgtgctgaa ttgggggctc atagctcgaa acatcaaacg 333781 cgggaaagcg ttattcaagg aagaaatcag cttccatatc cacttttcca ccggcgggcg 333841 gaagagaatt tcccccaatt tatattcagt gtcttttggg gtgagccact ctttggtgac 333901 tgcggattgc agggtcaatg tatttactct ttccggataa tgtgaggcaa agcatatgcc 333961 gctcggccct cctgctgaga tggcgatcac atggacactc tcgatttgta gatgatctaa 334021 taatttcaca tagaaacggc aggcattggc aagacttttt ccaatttctt ttgacgtccg 334081 tccatagcca ggccttgaag gcgtaatgat ggaataccct tgttcaatca acgctgtgta 334141 tccgaattcc tcgtaacaat ttgaatgccc gccatgcatg acaaggatcg gagttccctt 334201 gcctgtcaca gaatattcta gtgtaccgcc atcgaaggtg atcgtttcaa ctcgtctttt 334261 catctgtttc acccaattgg tttttgccta ttatagagtt ttcagcaatt gaccacaagg 334321 tagaagaaat gaataaacaa aggcccttga aatatgatat actttgtatt gatattcatt 334381 ctcaattaaa actttgatat agatgtgaac gggaggcagg acggatggct gagaatcaag 334441 aggtatatga cgttacgatt ataggcgggg ggccgatcgg gctgtttact gctttttact 334501 gcgggatgcg ggagctgaaa acaaaggtaa tcgaattttt gccgaagctc ggagggaagg 334561 tgtctttatt ctttcctgag aaaatcattc gcgatatcgg cggcataccg gggattgcgg 334621 gaaagcagct gatcgagcag ctgaaggagc aggcggcaac gtttgatcct gatatcgtat 334681 tgaatcagcg tgtgaccggg tttgaacgcc tagatgacgg caccattgtt ctgacgggtt 334741 ctgaagggaa aaagcactat acaagaactg tgattttggc ttgcggcatg ggtacacttg 334801 aggtcaatga gtttgacagc gaggatgcgg cccgatatgc gggcaaaaat cttcattatg 334861 gagtggagaa gctcgatgcg tttaaaggga aacgcgtggt gatatcaggc ggcggagata 334921 ctgcggtcga ttgggctaat gagcttgaac cgattgcggc gtctgtgact gtcgttcatc 334981 ggcgtgagga attcggcgga atggaaagca gcgtgacgaa aatgaagcaa tcatcggtgc 335041 gggtgcttac gccttatcgg ctggagcagt tgaacggaga tgaagagggc atcaaaagcg 335101 tgaccgtttg tcatactgag tctggccaga ggaaagacat agaaattgat gagctgatca 335161 ttaatcatgg gttcaaaatt gatctcgggc cgatgatgga gtgggggctg gagattgaag 335221 aaggaagggt gaaagctgac agacatatgc gaacgaatct tccgggcgtg tttgtggcgg 335281 gcgacgcggc tttttatgaa agcaagctga gattgattgc cggcggattt acggaaggcc 335341 cgacagcggt caacagtgcc aaggcttatc tggaccctaa ggccgagaat atggcgatgt 335401 attccaccca tcataaaaaa ttggtgcata aataaaacag cccttgagga aaagggctgc 335461 ttgccatcag gtgtgaagga gttttttctc tgcatgttga ttgtggatga aagctagcaa 335521 ttcatcctgt tcttgtacgg ctgtgaatcc ataaatgccg gcagctgagt catcgcctat 335581 gcagacgata ggagggcggc ttgctgacgg ttccggcaaa atgccaattt gttcgccacc 335641 attgatcaat tgctgaacgg acagcttgtt tgggcaaatg accatgtgca gcggggattc 335701 actgatggta cgctgaatca tgtgggtgaa ccggtcatct atgacgtttt catgagtgat 335761 ataaaacgaa caggattcat gcttttgcat gttttccact gcatggcggc tcccgacaac 335821 aagacgtttc tctgaatcag gctgaatggc ggtgacaaga aagccccgtt tctcaagctc 335881 tgtctttgct tgctcagatg ctgcactcag tttggctgtc agctggcgga tgtcgatttt 335941 ctgagaagcc agtgctctga aaaattcaca aaccgcccgg cgcgatgtga aaaaaacgtc 336001 ttcaaaggtg ccaatctttc gaagaatttc ttcattgaca ggcatgtttt cggtccgcca 336061 tttcggccac tcgatgagat cggcgccgga atcgcgcagc ttgtctgcaa gcgggtcttc 336121 atcttcgcca tgagtcacaa ccatcaaatg ccgtccgatg agcggtttgc tttcaaacca 336181 gctgtgtgtt tgaaagttga cgatgtctcc gatgacgata atcgcagggt ttgtaatctg 336241 gtgttcctgc actttttgct gaatgttctc aagtgttcct ttcacactcc gctggcggcc 336301 ccacgttccc cattggatga caatgacagg gacagaaggc gatttcccgt atgaaataag 336361 ctgctggcaa atataagaca agttcttgac acccatgtaa aaaacaaggg tttgaacgct 336421 tcgggccagc ccttcccagt caaggttcgg cgtgcctttt aatgatttat catgcgctgt 336481 aatcatggca aaagacgatg caaaatcccg atgcgtgacg gggatgcccg catatagcgg 336541 cgctgcaatt ccagaggtga ttcccggcac catttcatag cgaatgccgt gctcatgaag 336601 agcatctgct tcctcgccga ctctgccgaa tacgctcgga tctccgccct tcaagcgaac 336661 gacggttaac ccatttaatg ctttttcaac cagcagggcg ttaatttctt tttgtttcat 336721 aaaatggcgg tttggcagtt ttccgcaata aataaactgg cagtccggtg atgcaaattc 336781 gagcagcttc gggttggcga gccggtcata taaaatcaca tctgcttcct tgagcgcctg 336841 ttttcctttg atggtgagca ggcctgggtc gccgggtccg gctcccacga aatatacgat 336901 tccgttcttc atgatcatgt catccttccg tcactgtaaa aaatgaagga ccactagaaa 336961 agtgatccgg tcttttgatc aatatacgag ataaacatgt tctccttcga tcagcgtttc 337021 atatgttttg acgcatccgt ggtcaggttc ttggacgatt ccgtcttcta aggaaatttt 337081 ccagtcgtgc atcgggcaga aaacatattg accgctgacg atgccttctg ccaggacgcc 337141 gcccttatgc ggacagcggt tttcaatggc gcggatgctt ccgtctgaaa gcttgaaaac 337201 cgcgagctcc ttatcttcaa tatacactgt tttgcctaat tgttcaggca attcttcaat 337261 ttttccgata catacttttg ttacgtcttt gtttaccatg tccattcctc ctcaatgata 337321 gtttttgtca ttatgatgtg gtcacgacat tttcaaataa ttctttagag gtttgtttat 337381 cctctaaaaa gtctttccac ggatccttgt ggacagagag tgtttcattc attcggccgt 337441 tcagctcctg ccgcttttcc ggatcgttta acacggattg gacatgggat aaaccgacgc 337501 gctcaagcca tgcggacgta cgctccagat agtttgcggt ttccctgtaa tattgcaggt 337561 aagcgcccgc gtattctaag acttcttcat ttgttttcac cttcatcagc aaatcgccgg 337621 cacgcaaatg ggttccgccg tttccgccga cataaagctc ccagcctccg tcgatgccga 337681 caacgccaag gtccttaatg ccggattccg cacagtttcg cgggcaggca gacacggcca 337741 ttttgacttt gtgaggcgtg ttcagccctt cgaatttttt ctcaagcgca atgcccagtg 337801 ccatggagtc ttgtgtgccg aagcggcaga attgctcgcc tacacatgtt ttcactgtgc 337861 ggagcgtttt tccgtacgcg tagcccgatg gcatatcaag atcttcccat accttcggaa 337921 ggtcttcttt tttcacgccg ataagatcaa ttcgctggcc gcctgtcatt ttcacgagcg 337981 ggatctcata tttgtcaacg acatcggcga tcttgcgcaa atctgtggag ttggtcacgc 338041 cgccgtacat ccgaggaacg actgagtatg ttccgtcttt ttgaatattg gcgtgcattc 338101 gttcattaac aaagcgggat gtccggtcat cctcgtattt ggttggattg atcatgccta 338161 agtagtagtt cagagcgggt cggcatttag aacagccttc tggcgttttc cagccgagca 338221 cattcatgac ttctcttgta tgtgacagcc ctttggcttt gatttcttct acgacttcat 338281 ctctcgacaa tgtggtgcag ccgcaaatgg cttctttttg cgctgacgca tcaaagtctg 338341 atccgagcgt atgctggagg atttcttcta cgagcggctt acagcctccg catgagcggg 338401 atgcgccggt gcatgctttg atttcgtccg ttgacgagca gcccttttcc tgtatggctt 338461 gaataatcgc accttttgac acgccgttac agccgcagat gatttcatcg tcgctcatcg 338521 ctgcggttat gcttgtgcct gcttcctggc tgaggggctg taagattgat attttagagg 338581 tttcagagat atcggcttct ttttgaatca tagaaaacag gcgattgcct tcgctgctgt 338641 cgccgaataa aacagcaccg acaatttgat tgcctctcag gacaattttt ttatagatgc 338701 cgtcctgctc atcgaagact ttaatcgctt ttttctcctc tgattcgtta aagtcaccgg 338761 cagagaagac ctcgacgcct gataccttta actgtgtgga gagaacggag ccctcatacg 338821 gttttgtttc gatgccgcac atatgctttg ccagcacttt tgcctgttca tacagcggcg 338881 ccacaagccc gtaggcgatt cctcggtgct cggcacattc gccgaccgcg taaatgtgcg 338941 ggatttcagt ctgcatataa tcgttgacga tgatgccgcg gttaaccgga atgccgctct 339001 cggccccgag cgttgtattt gggcggatgc cgacagccat gacgactaaa tcagcttcaa 339061 tgcttgtgcc atccttgaat cggaggcctt cgacacggtc gtcaccgaca atttcttctg 339121 tttgcttttc aagtaaaaag gtcatacctt gtttttctaa ctcgttttgc agcaggcgtc 339181 ctgccgttgc atcaagctgg cgctccatca ggaatggggc aaggtggatg acggacacgt 339241 ccatgccgag attcagcagt ccgcgagctg cttccaaacc aagtagtcct ccgccgatga 339301 cggcagcttt tttatattgt tttgacgcgg cgagcattgt gtctgtatct tttatgtccc 339361 ggaaagctgt gacgcctttt ttgtctgcgc ccggaatcgg aaggataaaa gggaccgatc 339421 ctgtcgccag gatcaattca tcgtaaggct ggattctgtc tgcatctgtg atgactgttt 339481 tgttttccgt gtccactttg atgactgttt catttgtata caattgaatg ttgttttctt 339541 cgtaccagtc ccaatcgttt aacgtaatat ctttaatatc tgtatcgcct tgaagcactt 339601 ttgacaaaag gattcggttg taattgggat gcggttcggc accgaaaatt gtgatctgaa 339661 actcgtcttt agcaacactc agtatctctt caatggccct taccccggcc attccattac 339721 caacaagaac tagctgtttt tttcccatca gatgatccgc tccttatcaa atgttttttc 339781 cagcgtagca cagcaaaaag gaatatttaa gatacatgtt ataaaatgta acaaaatata 339841 cgaaaagttc taaaaatttt atgaaaaatt taaataggta tgattcggac ggcgcatacc 339901 ttaaaaccgg gcattttaca ggctggatct aaggcttccc cgattaaatc attcacattt 339961 tgagcgtctg cccaatggat gggaacaaaa acggtatctt ttctgatttg ttctgataat 340021 ttgctgcgga cggtgatgct tccccgcggc gattctattt ttaccagtac acggtcctcg 340081 atattgtagg tcgctgctgt ttgcggatgg atctccataa acgattcaaa atgtctcgcg 340141 gcaagggcgg cgctttttct tgtttggacg cctgttaagt agtgagacat gactctgcct 340201 gtcgttaaat aaagcggata atcggctgtc ggcttctctt ttggaacagg tggttcgttt 340261 ggaatcacac ttaatgccgc tttttgatcc ggatgagcaa atgattctgt aaacaagcgc 340321 ccagttccgg gatgatcaga ttccggacac ggccaatgaa tgccgccttc acgtctgagc 340381 ctgccgtatg agatgcctga ataatcggca atcccgcctc ggctcgcttc tctcaattca 340441 ttgaaaatat cctccgctga cgtataagaa aagtagcggc ccttgccgag agcggatgcg 340501 agatcacaaa tgatctgcca atcatgcttt gcttcgccgg ggcatggccg gcttgcttct 340561 cttaatgtca cgcgtccttc tacatttgtc atggtgcctt catcttctaa gtaagaggag 340621 gcaggtaaaa tcacatctgc gtatttcgca gtctcagaaa taaacaaatc gattgcgaca 340681 aagaatgtca gtcttcttaa agcctttttc acgagatttg catttggact ggaaacagca 340741 gggttggagc acatgaggaa cagtcctttg atgtcgccgt cattgatttt ttccatcatt 340801 tcataggctg agacaccttt tcgcgggagt tcatcctgat ggattcccca cactttcgca 340861 atatgcgccc ggtgttcttc gttttcgata gaacggtagc ctggaagctg atcggctttt 340921 tggccatgct ctctggcgcc ttgcccgttg ccttgtccgg tgatcgcccc gtagcccgag 340981 taaggtttgc cgatttttcc tgtgatcagc accatgttta agaagccttt cacagccgct 341041 gttccatcgg tttgctgttc aatcccgcgg gctgtaaaca gcatgccgga cgtttccttg 341101 gcaaacttca cagcagcttt tcttatatcc accagcgaga cactcgtctg ttcggcgatg 341161 tcattcaggt ccaacgagtc agtatgctgc ttcagctctt cgaatccatt tgttcgtgat 341221 tgaatgaaat cctcgtttat aagctgttcg tcaatgatga ttttgacgag accgttggca 341281 agggcggcgt ctgtgccggg tttgattttc agatgaagat cggcgatttt cgttgtcgct 341341 gtttcacgag gatcaatggc aatgaagtaa gctccgtttt ctttcgcttt ttcaaaatac 341401 ggcataatcg taggctggca ttccgcaata ttggtgccgg ccagaatgat cacacgggtg 341461 tgggggatgt ctgataaagg attcgttaag cctctgtccg cgccgaatgt ttggttggct 341521 gcggtggctg ctgcggacat acaaagtctc ccgttgtagt cgatgtattt tgtctgtaag 341581 cctactcgtg cgaacttccc taacaaatac gcctcttcat ttgtaatcga ggcgcttccg 341641 tataccgcca tggcgtcatg tccgtgttca gtttggatca ttgtcacttg gtctttgata 341701 tgattcagtg cttcttccca ggaaacaggc ataaactcgc cgtttttctt cagcagcggc 341761 cgggtgatgc gggaggagtt caaggcatgc tggtgagcat tcatgccctt gatgcatagc 341821 cgaccctgtg tcgtaggatt atcaatcccg atcgcagtgt actttttgcg cgtgacgatg 341881 gtttgttcca cgagctgcat tttgcactgc atgctgcaaa acgggcattg agtgtcatat 341941 gttttttctg attggacgtc ttgctgttta tcacggaaat atctaagcag tcgttcagtc 342001 aaaatgcctc atcctttctt atatgcgccc gtctctacag tcgggttttg aatcagtgac 342061 agatctgttt ggaggctttc cagcagctgt gcccttaggt cttcttcgaa tagcacttct 342121 ctgatatgaa cgatcccgag acggtctatc cactgatgaa caccttctaa gtaatgagcc 342181 gtttcccgat aatactggat cagtcctttg atcatgccgg cagtgctgtc ttcgttctca 342241 gtcacgcaaa acaaagctcc tgaacgggca tgagttcccc ggacgccgcc gatgtgaatg 342301 tcccagccag cttgtgtccg aattgcgccg acatcttgca gggcggcctc ggtgcagtct 342361 gtttcacatg ataagctgat agaaatggga gcgggtaagg gaagcatctc aagttgtctt 342421 tcgatttggg ctgccagctg ctgaatcgat cgattttgcc cgcatgtaca tgctttgatg 342481 ctttgcagcg cgtgtcggtg ttcattagtg taaacgggca ttttcaggtc ttttttcatg 342541 ttcgggagat ccgcaggctt gatcccggaa agcttcagcc tttggccgtg agtgatggat 342601 acgtcgggaa tgctgtatgc ctcaatgatg ttggcgatgg ttcttagctg ctccgcgttt 342661 gtccgcccgc cgtacatttg cggaatcagg atgcatgtct cttcagtggc tggctcaggc 342721 tggacaaacc cagggtacag catttccaga tagtattgaa tcgcaggaac acaagtactg 342781 catccgtttt ttgttttcca gtcaagctgg ttcatcactt ctgccggatt agtgaatggc 342841 ctgcgctgaa gctcagcgat gatgtcgtct tctgtaaaat cagtacagct gcaaaacgaa 342901 ggtgtgctgg cgggcttcgt atattcgctg ttggtcatgt atctcaaaag gtcttcaacg 342961 agcggtttgc atcctccgca ggacccagtg gctttggtgc agtgcttgac ttcctcaaca 343021 gttgttaagc tattcgtgtg caccgcgtct tcaatcgcgc ctttcgtcac tgtgttgcat 343081 tggcaaatcg tttcactgga aggcatggat tcaaataaag ggccgcttgt ctccggttcg 343141 atgatctgtt ttttggcaat ggagatgtct cgttgtttaa gcaggctgtc gagaagccgc 343201 tgcttgtcac gggtgtctcc gaataaaata acgccggcca gtttgtcatc tacaaaaagc 343261 gcttttttat aaacgcctgc ttgttcgtcg tagattttga tgctcgtcgt gcgttcatcc 343321 tcttggatct ttcctgctga ccacacatcg attccagcta tttttaacgc cgcagatggt 343381 gctgagcctt gatattcctc acatggaacg ccgcaaatat gactggcgag cgcttttccc 343441 tgctcataaa gcggagccac caatccgtac accgttccgt tatgctcagc gcattcacca 343501 acggcgtaga tattcggttc gcttgtctgc atgaagtcat tcacgatgat cccgcggttc 343561 actttgattc cagcggatac agccaattca atattcggtt tgacgccggc cgccatcaca 343621 atcaagtctg cttttaatga agagccatct ttaaaatgga ttcggtctgc cttcgtggcg 343681 ccggaaatgg agacggtgtc tttctccaaa agaaaggtta ggcctttttg ttccagctct 343741 gtttgcagca gccgcgccgc tgtttgatcg agctgttttt gcataatgcc ggcggagtgg 343801 tgaatgacgc tgacatccat accgagatgc tgtaaaccta ctgcagcttc cagtcctaat 343861 aagccggctc cgattaccgc agccttttga aagtgctggg ccatgttcat cagcgcttgg 343921 cagtcttcta ttgtccgaaa tccatagaca ccttttttgt ctgccccggg gatagggaga 343981 atatgagggg aggagcctgt tgccactatt aatttgtcat acgacagagt gcgtttccga 344041 tctgtgatga cctgctgctg atctgtatca atctgaataa ccgtttcgcc tgtgtaaagc 344101 gtgatcccgt gcttgtcgta ccaatccttg ctgttcagtg taatatcatc gagtgacgct 344161 tcaccctgca atacagagga taagagaatg cgattgtaat tgggatgcgg ctcgcttccg 344221 aaaatgacaa tctcaaacat gtggcgattc agctttaata cttcttcaat acagcggatt 344281 ccggccatgc cgtttcccgc taacactaat ctttgtttct tcatgtatca gacctccttt 344341 ggcgaagctc gtaagttttc tcctattaaa aattatgtca caatgcattg ttaacgcatt 344401 aaacgtgtca caaaaactta cacatgtctt ttccagaaaa taatggtcct atatccttga 344461 ttcagaaaat gtaaaataat gagggtctag aaaggggaat cttatgaagc tgtcggaact 344521 gaaaactagc ggtcatccac tcactttgct ctgttccttt ttatactttg atgtcagttt 344581 tatgatatgg gttatgcttg gggcgctggg tgtttatatt tctcaggatt ttggcctgtc 344641 tccttttgag aaagggcttg tcgtagctgt gccgatttta tctggatctg tgtttcgtat 344701 cattcttggt attttaacgg acagaatcgg accgaaaaaa acggcagtga tcgggatgct 344761 ggtgacgatg attccgctgc tttgggggac attcggcggc cgttccctga ctgagctgta 344821 tgccatcggg attctgcttg gcgtggcggg agcaagcttt gctgtagcgc tgcctatggc 344881 cagccgctgg tatccgcctc atttgcaggg acttgcgatg gggattgccg gagcggggaa 344941 cagcggcacg ttgtttgcaa ccctgtttgg ccctcgtctg gcagagcagt tcggctggca 345001 cattgtcatg ggaattgcgc taattccatt attgatcgtc tttattcttt ttgtatccat 345061 ggcaaaggat tcccctgcac agccgtctcc ccagccgctc aaaagctatc tgcatgtgtt 345121 tgggcaaaag gaaacatggt ttttctgcct gctgtacagc gtcacatttg gcggatttgt 345181 cgggctctca agctttttat ctattttctt tgttgatcaa taccagctgt caaaaattca 345241 cgcaggggac ttcgttacat tatgtgtggc ggcggggagc tttttccggc ctgtcggggg 345301 cttgatttca gatcgtgtcg gcggcacgaa agttctttct gtattgtttg tcatcgtggc 345361 actgtgtatg gccggagtca gtagcctgcc atctctctca atggttattg ttctattgtt 345421 tgtcggaatg atggggctcg gaatgggaaa cggcgcagta ttccagctcg tgccgcagcg 345481 cttccgcaaa gaaatcggca tggtgacggg aatcgtcggt gcggccggag gaatcggagg 345541 gtttttcttg ccgaacatct taggatctct caaacagatg acaggcacat atgctatcgg 345601 ttttatcacg ttttcctgta tcgcgctgct ggcgtttgca cttgtgcttg ccgcaggcta 345661 ttactggcgg aaaagctgga gcgcggaaag cagcccggcg gatgtttagg attttgacgg 345721 acacgcgttt gtgcgtgtct tttttatttt ctcttgattt tcaacagtga accgatcaaa 345781 ataaatagta attattacga tttgttagtg agaggagttt tctgaatgaa tcaacatacg 345841 ctgctcccga aaaaaacgga gcgtcttcaa tactttggat cggtcagtcc gatcaaaggc 345901 gagaaaccag tggaaaaaga gaaaatgaag gacctgcaaa atatcaggaa ggattatttt 345961 tttgacattc agcatgtagg tgtagctaat gtgtcccatc cagtcacaat cacttctgcc 346021 atgatgcctg ccgagcaaac aacggctgcg aactttacaa tgacttgtaa tttgccgaga 346081 aatcagaagg ggattaacat gagccggtta acagagctgc tgcaagtcta tcatcaaaat 346141 ggctggattc tctcattttc ctctcttcag caatttacga aagagcttgc agaaaacatg 346201 gacacatcat ctgccacagt tgaagtgagg tttccgtggt ttttcgaacg gaaaagcccg 346261 aagcttgaga aagcgggttt gatgcatgct gatatattca tgtctgtcac ctatcgcaaa 346321 gatcagccgt ttaaacagcg tgccggcatc tcagcaaaag taacgactct gtgcccttgc 346381 tccaaggaaa tcagcgaata cagtgcccat aatcagaggg gaacggtcag catttgggcg 346441 gatattcacc cggccgcatc gctgccaagt gatgttaaag ctgatttgct tcacgccgca 346501 gaatcaaatg cttctgcgag actgcatccg gtattgaagc ggcctgatga aaaagccgtg 346561 acagaaacgg cctatgaaaa cccgagattt gttgaggatc tcgcccggct gattgctgca 346621 gatttgtttg agcttgaatg ggtgtcagcc tttgagattg aatgccgaaa tgaagaatcg 346681 atccatcttc acgatgccta tgcgaagctg tgtttttcga aggaagtgga taaaatatga 346741 aactctcatt attcattatt gcagttctta tgccagtcat cctgctgtca gcctgctccg 346801 atcatgcaga agaacacgca agtatcaata caaagaaaac ggtcgaaaac ataacggacg 346861 ttcgaaaaac agcaaaaaca agcattgatt ggacaaagcc ttcgggcgga gaatacccgg 346921 atattaaaca gaagcatgtc tggattgatg tgaatgtgaa ggagcagaag gcttacatca 346981 aggaaggaag caacaccatc tatacaatga tgatttcttc tggtcttgat caaacaaaag 347041 atgatgctac gccaaagggc accttttatg tagagcctga acggggagaa tggtttttct 347101 ccgaaggata ccaggaaggc gcagaatact gggtatcatg gaaaaatcac ggtgaatttt 347161 tatttcatag tgtgccaatg actaaggatc aaaaagtcat caaaacggaa gcagaaaaac 347221 taggaacgaa agcatctcac ggatgtatca ggctgaccat tccagatgcg aaatgggtat 347281 atgaaaatat ccctgaacat acaaaagtgg tgatcagctg aattgaaaac cgttgacaaa 347341 aaggaaaaaa gaccatacaa tttaaatcgt aacaattacg ttttatgata aatggcttat 347401 cattgtctgt gcatctgtga aaagcggaaa ggcatcgatt aaggatcttg ctgtcggcaa 347461 aggcaaggat ttgcgatggg gaaaaggatt aaacgcggtt ggagtcttta ctgatttaga 347521 aatcgggcgg cagcgagaaa tgagcgcgaa aagctgctct acaccattgt acatacggcg 347581 aagtattcaa tttaaatcgt aatcattcta ttttaatgga ggcactatta tgaaaaaaat 347641 tccggttacc gtactgagcg gttatctcgg tgcgggaaaa acaacattgc tgaacagcat 347701 tttgcaaaat cgcgaaggct tgaaaatagc ggttatcgta aacgatatga gcgaggtgaa 347761 cattgacgcg ggcttggtta agcaggaagg tggcctttcc agaacagatg aaaagcttgt 347821 ggaaatgtca aatggctgca tttgctgcac gcttcgcgaa gacttattaa ttgaagttga 347881 gaagctggca aaagacggac ggtttgatta tatcgtcatc gaatcgacag gaatcagcga 347941 accgatcccg gtggcccaga ctttctctta tatcgatgaa gagatgggaa tcgatcttac 348001 aaaattctgt cagctggata cgatggtgac ggttgttgat gccaaccgtt tttggcatga 348061 ttatcagtca ggcgaaagcc ttctggaccg caaagaagca ttgggggaaa aggatgaaag 348121 agaaatcgcc gacctcttga tcgatcaaat tgagttttgc gatgtactga tcttaaataa 348181 atgtgatttg gtcagcgagc aagagctcga acagcttgaa aacgttcttc gtaaactgca 348241 gccaagagcc aggttcattc gttccgtcaa aggaaatgta aaaccgcagg agattttgca 348301 tacagggtta tttaacttcg aggaagcgag cggatcggcc ggctggattc aagagctgac 348361 ggcaggccat gcggaacaca ccccggaaac agaagaatac ggtatctctt catttgtata 348421 taagagacgt ttgccgtttc attctacacg attttaccgt tggttggatc aaatgccaaa 348481 gaacgtggta cgtgccaaag gaatcgtctg gtgcgcatct cataacaacc tcgctttgct 348541 gatgtcgcaa gcaggtccgt cggttacgat tgagcctgta tcttattggg tggcggcgtt 348601 gccgaagctt gagcaggagc aagtcaaaca gcaggagccg gaaatcctgg aggagtggga 348661 cccggagttc ggcgaccgcc taacgcagct agtttttatc ggaactgacc tggatgaaga 348721 aacgatcacg aaagagcttg atcaatgcct gttgactgag tatgaatttg attccgactg 348781 gtcgctgttt gaggacccgt ttaaatggaa gctgaatcaa tagaaaaaaa gccgtcccat 348841 ggggaacggc tttttttaat gaaacgtttg tttaaacata atgagcgtat tttttctcaa 348901 ggatattctg aaagaccgcg gcaatggagc agatggccca ataaatgaga gcggtcagaa 348961 tatacatggt catataatca aactctctgc ccccgatgat tttcgcatgc tggagcaatt 349021 ccggcactgt aatcatcgca gcgagagagg acgccttgat caagtcgagc aatacattgg 349081 caagcggagg cagcgcaata cgtatcgatt gcggcaaaat gatgcccctc atcgtctgcc 349141 aataggaaag acccagcgag gatgcggctt cccactgtcc tttttcgacg gatgaaatgg 349201 ctgaacggtt aatttccgca atgtaggcgg cgctgtttag gctaaagccg attaaagcag 349261 ccgtgacagc ggaaaattca atgccgatat aaggaaaccc gaaataaagg ataaacaaaa 349321 tcaccaaaat cggaacgcct cgcataaatg agatatagag cttcgccggc catcttaaca 349381 aagcaagttt agacattctg gcgagtgata tgaacaggcc gatcacagtt cccgcaaaca 349441 tgcttacaaa agagatgagc agtgtataac caatgccttt tatgacataa gggaacgatt 349501 caatggccag cttcgtgttg aaaatatatt cccactgaat gctattgatc atggcgtccg 349561 attacaaatc aacgtcctga acgtcggcat caattttttt tgatacatct gctttattga 349621 agaattgttt cgacagttta gtcaaagagc catccttgct catctctttc aatgcttcgt 349681 tcatcttttt ctgaagtgcc gcattgcttt ttttcatgac aagggcctgt ttgttcggca 349741 tgtacttgat gtcaggatga attgtaatgt tgagatccgg gaatgccgcg agcgcaagtg 349801 tctgcaggta atagtcgttt aaaatgacgt cagtgcgtcc gttggcaaca tcttttaaat 349861 attgctcatt cgtcgcatta tcataaatca cttctttggc gccgtatttt ctcgcgacct 349921 ccatgtagac ggttgtagcc gcgccagccg ctttcttccc ttttaaatcc ttgagcgttt 349981 taatccctga taaatcgtct tttcggacaa ttgccgtgcc gtatgaatat ttatatggag 350041 tggaaaatgc gaacttctcc tcacggtcct tcgtcacatc gatgtcattc gcggctgcgt 350101 caacctgtcc gctgttcacc gctgtcagca tcccgtcaat gcccatctcc ttgaactcaa 350161 ccttcagccc caagcgtttt gccgcttcac gaacaacttc aacctcgtag cccgtcagct 350221 tatcagagcc agagtcagta tcgtgataag aagtgggata gagcgtacct gatgtagcga 350281 ctacgatttt ccctttatcc ttaatctgct cccagcctgt atccttggaa tcggcttcat 350341 ttttgccgga acaggctgcc aatataagaa agaaagccat tgtgaaactg aatataacgg 350401 ctttggaatg catgaatgat ttcacctata gttcccccaa tctgttaatc aactaaaaag 350461 atagcattga acataagggg ttgcaatatg ttgatcgcgt tttcaaaaag ttcgaattgt 350521 gtatacaaaa agcatgggtg ggtgtttaaa agcgtctatg aagggaagag gtgatgaaaa 350581 aaggaattgt ccaaggatga atgccagacg taccaaggaa acgcatgtga aagtgaagga 350641 tgcagcagac ccgtcactca tctatgccaa taccggaaga aatggtcaag aggcatgaaa 350701 ccgatcttca gaataaattt aagtcttgct gatgccccta aggcatatga tatattcgat 350761 gagaaagaaa atggaaacat ttaaaccata atggggagtc aaatgaatat ttacaaacca 350821 gccggatttt ggatcagact tggagctgca ttgttagact acattatagt ctccgtgccg 350881 cttttgctga tctattggct gattacagga aaagacccaa acgacagcat gttcatcagt 350941 ttggttgttc tgctgtattc tattttgctg ccgatgtttt ggcgcggtta tcttatcgga 351001 aaaaggatct gcggaatcag aatcgtaaaa aaagacggat cacaggtcag tctgttaaca 351061 atgtttttac gggttattgt agccggcctg gtttactgta taaccttcgg actcggcttg 351121 atcgccagcc tgattctgat tgccgtacga gaagacaaac ggaccctgca tgatttaatc 351181 gcgggaacat atgtcactta tgcgacacca ggtgaagagg aacttaatgc tgacgaagag 351241 attagaaaga gcgaataatg gttcgctctt tttattttta tgcataaaaa atacaaggca 351301 gcaaaacata tgaaaaatag gattggagga ataaaatgga tgaaacgaat aaccatcaac 351361 attatcacaa tgttcattgc agcggctgtc atttctctga ccggtacagc tgaggccgct 351421 gaaaaacagc agcagtctcc cgcaaatgtt acactgacag atcagcaaaa gaaagagatt 351481 gaacaactgg aagcagagat tcttaaaaag cgcaaagacg tgatctcaaa gtatgtacaa 351541 tacggtatcc tgcctaaaga aagaggagaa cacatcaaaa atcacttgga caaacacttt 351601 gaaatgatga aacaaaacgg ctttgttcca aagcaccatc ctcatccgca taaatttgaa 351661 aaaagacatt aagattttaa gcatccaatg ggaattgggt gcttttgcgt tatttacagg 351721 taggcaatat tagctgagct gttccgcgac taacatcgag ttgatatgaa acgcgtttca 351781 tagcctatga taggtttatc aaataattca ggagtgataa acactatgat ccaccagcat 351841 ccagaatctt ttccgaaaca ttttttgtgg ggctctgctt ctgcagcgta ccagattgaa 351901 ggcgcttgga atgaagatgg caaaggccct tctgtttggg atgtgtttac gaaaataccg 351961 ggcaaaacgt ttaaaggaac caatggcgag attgcggttg accattatca ccgatttaaa 352021 gaagatgtcg ctctgatggc tgagatgggg ttaaaagcat atcgattttc cgtcagctgg 352081 ccacgggttt ttccaaaagg aaaaggagag atcaatgaag caggtctagc gttttacgat 352141 agtctgattg atgaattgct ttctcatcac atcgagccgg ttctgacttt atatcactgg 352201 gatttgcctc aagcgcttat ggacgaatac ggcgggtttg aatccagaaa catcatagag 352261 gattttaatc actactgtat tactctttat aaacgttttg gagacagggt gaaatattgg 352321 gttacgttaa acgaacagaa ctacaatttt aatcacggat ttattacagc catgcatccg 352381 cctggagtga aagacagaaa acgattttac gaagcaaacc atattgcgtt tctggctaat 352441 gcaaaagcca tcgaatcatt tagagaatat gtgcctgaag gcaaaatagg tcctagcttt 352501 gcttattctc cggcttaccc tttatcaagt catccagagg atatactggc atttgaaaac 352561 gccgaagaat ttacgaacaa ttggtggctt gacatgtatt gctggggaac ctacccgcaa 352621 attccattcc gctgcttgga aaaacaggga tgggcgccga caattgaagc aggagatatg 352681 gacctgctcg ccaaagggaa gcctgatttt gtaggtgtca attattatca gacgatcacc 352741 tatgaacgaa atccgcttga tggtgtgtca gaagggaaaa tgaatacgac aggccaaaag 352801 ggaaccaatc aggagacggg gatacccgga gtgttcaaaa cgaaaaaaaa tccgcatctg 352861 acaacgagca actgggattg gacaattgac ccaattgggc tgcgtatcgg tcttcgccga 352921 attacaagcc gctatcagct tccagtgttt ataacagaga acggtttggg tgaatttgat 352981 aaagttgagg acggcactgt acaggatgat tatcgaattg attatttgcg ttcgcatctt 353041 gagcaatgca gacaagccat cagtgacggt gtcgatttaa tcggctattg cagctggtcg 353101 tttactgatc tgttaagctg gctgaacggc taccaaaaaa gatacggatt tgtatatgtc 353161 aatcgtgatg aagaaagcac atccgattta aaacgcttga agaaaaaaag cttttattgg 353221 tatcaagatg tcatcaagac aaacggagaa agtttataaa gagtccctga gagttattct 353281 ctcaggggtt tttcattaca cagaaacagc atcaataata taagtgtcgg cgtgcaaatc 353341 tgacatttca gccggcacag tccagcatgt caattgatag tctcctttag gcagatcaaa 353401 ggacagtctt ttagacatga tgctttcaat atgaattccg ttttctgtga catgaaaagg 353461 aacagtcact tttttttcgt aggagtttac tgtttctgaa ctgttcaggc gaaaaagaat 353521 aaaggccttt gtatttcgct gtgcctcaaa ggaaatggct ccgtctgccg cagcatatcc 353581 tttttcaatc gcttcgtcag tccaatccat tacaggaggt gtagaatcct tttgaaatac 353641 agtaaattga tgatatgaaa tcgaaagttc ttgcggcttc catgatttga tcaatgtgct 353701 gttcctcctc tatgtactgt ttactgaatt gtgaataaaa cctttgtgcc gtctgggtaa 353761 tcggtaagcc gatgcccgac ccaagagcct gctccgcggt tgtcagcggg agaaatgtat 353821 tctacagaag ctccctcacc gccttctttg cacatggcca ttggccattc atctctgtca 353881 tacccctttt tggaaggtac gtcctttaat gattgctcgc ggcgttcttc agctccgtct 353941 ctgtcaatag tgcacacctc tgagtgcccc tcatttatcg catccttaat atgcttggca 354001 gtttcgggat accggtcaga tgggaaggcc attgtttcat catattcttt cgtttgagac 354061 gttttttgat cagctgagaa aaagtctcct tttatcaggc cgacagctgc agctgctatg 354121 atgacgatga cgagaagtat cgtttttatg atgtccgtcg tgatgttcac ctcccgcttt 354181 taaaactgac acaagagtaa tccagaaagc atttggtgta aaggtttaaa ttttatgttt 354241 tacgatcagt ttattgcaga aatcgtaatt ttagcagatc gaaatatttg ttttcagcaa 354301 aatacgattg ccaatttaca ataatgatag taagtcatca gccgttttcg gcttgattaa 354361 tcattttaaa ttggcttatg ataccggtaa gctcctcagc taattgagaa agtgtttcag 354421 aagctgcggt aatctcctcc attgcagcaa attgctcctc tgttaatgca gccgcttgcc 354481 gggtattttt agtagattct ttaatgtcgg ccgtattggc tgcaaaggaa tcatttattt 354541 gatgtgcact ggctgaaatg tttgttacag atgctgataa atcactaatc tcggcgctga 354601 tttcacctgt tgcagctgca atttccttaa atgcatctct ggtgcgctgg atcatggtga 354661 ctccttctgc agcttctgtt ttcacatgct caacagatct tgcagaccgg ttcatatcct 354721 tttgtatttc tatgatcagt tttgaaatct gccccgcaga ctgttgagac tcttctgcta 354781 atttccgtac ttcatcagca acaacagcaa agccttttcc ttgttcaccg gctctggcag 354841 cttcaatcgc tgcattcagc gcaagcaggt ttgtctgatc agcaatttgg gtgatgaccg 354901 ataaaatttg ctcaatttgt ttagagcggc cgtctaactg gtgtatgatt tctccgcttt 354961 tctgaattga ctggtgaatc gcatccattt gcgcctgtac atttgcaatt tccttttgtc 355021 caatgtctgc ttttgattga gcgagctgcc ctttgtcagc gatagcggca gtatttgcag 355081 aaatatcccg gatgtctgct gaagcttgtt ttaatgagct ttcactattt tcaattcggg 355141 tgatctgatc ttgggctcca tttgcaatct gctgtacagc ttctgtgatt ttttctgaag 355201 cttgatttgt ttcctctgct ccggctgaga gctgctgaga ggctgacgca agctgaaggg 355261 ctgattgttg tacggtttgt atggtatcgt tcagcttcat tctcatctta ttataataga 355321 cgcttagttc tgaaagctcg tcaccggttt tgtctgacac ctctattgtc atatctccgt 355381 ttccggcact ttcaaaggcg ctttttaaag cgttcagccg cttgttgatt tttctggtga 355441 aaaccaagac aaggatgact gataccataa tgacgataac aagaacgata gcgaattgag 355501 tgaaaagtga ttgtgtaagt gatgctaaaa tactttgatt agctccggta tacagcatgc 355561 cgatgatgtt cccattttga tcttttaacg gcatgtatgc agtctgataa gaagaacctg 355621 ctacatctgc ttgtccgtaa aaacgctttc ctttctttaa aacagcggca ataacttcag 355681 aagaagcctg ggtgccgacg gctctttcgc catttttcat gacattggtt gcaacacgag 355741 tatcgccttg gaaaatggta atggtatcac ctgtcttttc accaagcaga tcaacaatat 355801 cttcatttcc attgatttgt gtttgccctt tatagagctt attgtttttc acctgccagt 355861 cgcctgacat gacatcatca atataagtgc tgcttaaagc gagatcacct ttcgcttttt 355921 cagttgccat ttgtttcatg ctttctgtaa tttccttaag catcacagtg ccaactgatg 355981 ccgaaaacaa aagaatcacc acgaaaacga ggcaaagaat tttagttcct agcttcatct 356041 taaatcgttt tatcaacata attcctccct ttacgatttg caggtcatat tacttatcgg 356101 gtttttgggt ttaaagtttt attttagaaa aaataaaacc ggcctgatct tcaggccggt 356161 tgtgtgatgc tattcaaggt ttgcgtggtg agtgaacata gtttcagaat cgagaccttt 356221 tttctccatg agttttaaaa tcactgcatc atagaagagc agcaaagttt gttcaaataa 356281 tgatcccatt ggctgaatgg ttttatagct tccgttagac tggtctttag gggaaccagg 356341 cattctgatg atgaggtccg cttgttttcc gatgcttgat tccggattga tggttaaagc 356401 ggcaacaatt ccgtgtaagc tttttgcttt tgctgcggta tgaatcaagc tctttgtctc 356461 gcctgatcct gagccgataa taactagatc tccttcggcg agcggcggag tgagaatctc 356521 acctactata tgggcgttga agcccatgtg catcagtctc atcgcgaagg attttgccat 356581 caggccagac cgccccgcac ccgcggtgaa aatttggtgg gatgaaagaa tgtgatcggc 356641 aagctggtca gcttcttcat tagaaatata agctgctgaa ttgtgtaact cattgagaat 356701 ttccgctacg tattcagtcg ttttcatcgg agttatcctt ggacaatcag ctgcttcatt 356761 tttgaagctg tttccgcctt atcagctgcg cttgtaattc cgcccccgac aatgacaagg 356821 tcaggctttt gctggatcac ttctggcagt gtatcaagtt tgatgccgcc cgcgattgcg 356881 gtttttgcgt tttttacggt atttttgatt gtcgttaatt cttcgaaaga gtttttgccc 356941 tctgcttgaa gatcatagcc agtgtggacg cagatgtagt caacaccgag tgcgtcaatt 357001 tctttcgcac gggattcgat atctttcacg ttaatcatgt ccactaagat tttcttcttt 357061 tgttttttgg cttcttctac tgcgccttta atcgttgcat cgtctgtagc ccctaaaacg 357121 gtgatgatgt cagcgcctgc ttccgacgct ttcataattt cgtagcctcc ggcatccatg 357181 attttcaggt ctgcaagaac cttcaattga ggaaatgctt cttttatttc tttaacggct 357241 cttaggcctt cattgatgac gaccggtgtt ccgatttcaa ctacgtcgat gtattgttct 357301 acctctttga caagctcaat ggcttccggg atgttgacga ggtctaatgc aagctgtaat 357361 tccattgttg atccactccc tttttcgaat tattgttcat tctataggtt ccttcttttg 357421 ttgagaagta ggcactttga agtcaacaag ttacttggag gatactgtga ggagagacaa 357481 tcagatttct ttcgcttgat tttatgagtg agtataatga aaaaagagtc tgcaaaaaag 357541 taagtaagtg atgatacgta tctaacatac aaaaaggtta ctaagggggg ggattctatt 357601 gagccggatg gacgacaaaa ggtttaattg tgagaaggaa ttaacgcttg cagtgattgg 357661 cggtaaatgg aaaatgctca ttttatggca tttaggaaaa gaaggcacaa aacggttcaa 357721 tgaattaaaa acattgattc ctgatattac gcagaagatc ctcgtgaatc agctgagaga 357781 gcttgagcag gatatgattg ttcacaggga agtgtatcca gttgtcccgc cgaaggttga 357841 atattctctg accccgcacg gagaaagcct catgcctatt cttgaagcca tgtatgagtg 357901 ggggaaaggc tatatggaat tgattgatat cgacaaaaat gtcatgaaag aatcgttgta 357961 agacgctctt cgcaagggtg tctttttttg cctttttttc ggtttttgcg cggtacacat 358021 agtcatgtaa agattgtaaa ttgcattcag caataaaaaa agattgaacg cagcagtttg 358081 gtttaaaaat ttttattttt ctgtaaataa tgtttagtgg aaatgattgc ggcatcccgc 358141 aaaaaatatt gctgtaaata aactggaatc tttcggcatc ccgcatgaaa cttttcaccc 358201 atttttcggt gataaaaaca tttttttcat ttaaactgaa cggtagaaag ataaaaaata 358261 ttgaaaacaa tgaataaata gccaaaattg gtttcttatt agggtggggt cttgcggtct 358321 ttatccgctt atgttaaacg ccgcaatgct gactgacggc agcctgcttt aatagcggcc 358381 atctgttttt tgattggaag cactgctttt taagtgtagt actttgggct atttcggctg 358441 ttagttcata agaattaaaa gctgatatgg ataagaaaga gaaaatgcgt tgcacatgtt 358501 cactgcttat aaagattagg ggaggtatga caatatggaa ataacttttt accctttaac 358561 ggatgcacaa aaacgaattt ggtacacaga aaaattttat cctcacacga gcatttcaaa 358621 tcttgcgggg attggtaagc tggtttcagc tgatgcgatt gattatgtgc ttgttgagca 358681 ggcgattcaa gagtttattc gcagaaatga cgccatgcgc cttcggttgc ggctagatga 358741 aaacggggag cctgttcaat atattagcga gtatcggcct gttgatataa aacatactga 358801 cactactgaa gatccgaatg cgatagagtt tatttcacaa tggagccggg aggaaacgaa 358861 gaaacctttg ccgctatacg attgtgattt gttccgtttt tccttgttca ccataaagga 358921 aaatgaagtg tggttttacg caaatgttca tcacgtgatt tctgatggta tctccatgaa 358981 tattctcggg aatgcgatca tgcacattta tttagaatta gccagcggct cagagacaaa 359041 agaaggaatc tcgcattcat ttatcgatca tgttttatct gaacaggaat atgctcaatc 359101 gaagcggttt gaaaaggaca aggcgttttg gaacaaacaa tttgaatcgg tgcctgaact 359161 tgtttccttg aaacggaatg catccgcagg gggaagttta gatgctgaga ggttctctaa 359221 agatgtgcct gaagcgcttc atcagcagat tctgtcgttt tgtgaggcga ataaagtcag 359281 tgttctttcg gtatttcaat cgctgctcgc cgcctatttg tacagggtca gcggccagaa 359341 tgatgttgtg acgggaacat ttatgggcaa ccggacaaat gcgaaagaga agcagatgct 359401 tggcatgttt gtttctacgg ttccgcttcg gacaaacatt gacggcgggc aggcgttttc 359461 agaatttgtc aaagaccgga tgaaggatct gatgaagaca cttcgccacc aaaagtatcc 359521 gtataatctc ctaatcaacg atttgcgtga aacaaagagc tctctgacca agctgttcac 359581 ggtttctctt gaatatcaag tgatgcagtg gcagaaagaa gaggatcttg cctttttgac 359641 tgagccgatt ttcagcggca gcggattaaa tgatgtctca attcatgtaa aggatcgatg 359701 ggatactggg aaactcacca tagattttga ttaccgcact gatttatttt cacgtgaaga 359761 aatcaacatg atttgtgagc gcatgattac catgctggag aacgcgttaa cgcatccaga 359821 acatacaatt gatgaattaa cactgatttc tgatgcggag aaagagaagc tgcttgcgag 359881 ggccggcggt aaatctgtga gctaccgtaa ggacatgacg ataccagagc tgttccaaga 359941 aaaggctgaa ctgctttctg atcatccagc ggttgtattt gaagatcgca cattgtccta 360001 tcgaacgtta catgagcaat ctgcacgcat cgccaatgtg ctgaaacaga aaggggttgg 360061 cccggacagt cctgtcgcgg ttttgattga acgctctgaa cggatgatta cagctatcat 360121 gggaatttta aaagccggcg gagcctatgt gccgattgat ccgggttttc ctgctgagcg 360181 cattcaatat attttggagg actgcggggc ggatttcatc ctgactgaat cgaaggttgc 360241 ggcgcctgaa gccgatgctg agctgattga cttagatcag gcgattgagg aaggtgcaga 360301 agaaagcctg aatgcagatg tgaacgctcg gaaccttgcc tacattattt acacatcggg 360361 aacaaccgga cgcccgaaag gcgttatgat cgagcatcgc caggttcatc atttggttga 360421 atctctgcag cagacgattt atcaaagcgg cagccaaacc ctgcggatgg cattgcttgc 360481 gccgttccac tttgatgcgt cagtgaagca gatcttcgcg tcgcttcttt tgggccaaac 360541 cctttatatc gtaccgaaga aaacagtgac gaacggggcc gcccttactg catattatcg 360601 gaagaacagc attgaggcga cggacggaac accggctcat ttgcaaatgc tggcagcagc 360661 aggcgatttt gaaggcctaa aactgaagca catgctgatc ggaggagaag gcctgtcatc 360721 tgttgttgcg gacaagctgc tgaagctgtt taaagaagcc ggcacagcgc cgcgtttgac 360781 taatgtgtac gggccgactg aaacgtgcgt tgacgcgtct gttcatccgg ttatccctga 360841 gaatgcagtt caatcagcgt atgtgccgat cgggaaagcg ctggggaata accgcttata 360901 tattttggat caaaaaggcc ggctgcagcc tgaaggcgtg gcgggtgagc tttatatcgc 360961 gggagacggt gtgggccgag gctatttaca tttgcctgaa ttaacggaag agaagttttt 361021 acaagatcca ttcgtgccgg gcgatcgcat gtaccggacc ggggacgtgg tgcgctggct 361081 tccagatgga acaatcgaat atttaggcag agaggatgac caggtcaaag tccgcggata 361141 ccggattgag cttggggaaa ttgaagccgt gattcagcag gcgccagacg ttgcaaaagc 361201 cgttgttttg gcacgccctg acgaacaggg aaatcttgag gtttgcgcat atgttgtgca 361261 gaagcctgga agcgaatttg cgccagccgg tttgagggag catgcggcca gacagcttcc 361321 tgactatatg gtgccggctt actttacaga agtgacagaa attccgctta caccaagcgg 361381 caaagtcgac cgccgcaagc tgtttgcact agaggtgaag gctgtcagcg gcactgccta 361441 tacagcgccg cgaaatgaga ctgaaaaagc aatcgcagcc atttggcagg acgtgctgaa 361501 cgttgagaag gcggggatct ttgacaattt ctttgaaact ggcggacatt cattaaaagc 361561 catgaccctt ttaacaaaga ttcataagga aacaggcatt gagattccgc ttcaattttt 361621 gtttgagcat ccgacgatta cggctcttgc agaggaagct gatcacagag aaagcaaagc 361681 ttttgcggtg attgaacctg ctgaaaaaca ggagcattac ccgctttcat tggcacagca 361741 gcgaacatat atcgtcagcc agttcgagga tgcgggagtc ggctataaca tgccagcagc 361801 agcaattctg gaagggcctt tagatattca aaagctggag cgcgcatttc agggattaat 361861 ccgacgccac gagtcattga gaacatcatt tgttcttgaa aacagcacgc cgagacagaa 361921 aattcacgat agcgttgatt tcaacatcga aatgattgaa agaggcggcc gctcagatga 361981 ggcaattatg gcttcattcg ttcggacatt tgatttggcg aaagctccgc tgttcagaat 362041 cggtttgctg gggcttgaag agaaccgtca tatgctgctg tttgacatgc accatttgat 362101 ttctgacggt gtatccattg gcattatgct ggaggagtta gcacgcattt ataaaggcga 362161 acagcttcct gatcttcgtc tccagtataa ggactacgct gtatggcaaa gcagacaggc 362221 tgctgaaggg tacaagaagg accaggctta ttggaaggaa gtctttgcag gcgagctccc 362281 ggtgcttcag cttctgtccg attacccaag accacctgtt caaagctttg aaggggatcg 362341 ggtgtcaatc aagctggatg cgggggtaaa ggatcgcctc aatcgtttgg ctgaacaaaa 362401 cggcgccact ttatatatgg tgatgctttc cgcttactat acgcttttgt caaagtatac 362461 ggggcaggat gacatcattg tcgggacacc gtcagcgggc agaaatcact ccgatacaga 362521 gggcattatc gggatgttcg tcaatacgct tgcgattcgc agtgaggtga agcagaatga 362581 gacgtttacc caattgatct cgcgtgtccg caaacgggtg ctggatgcct tttctcatca 362641 ggactatccg tttgagtggc ttgttgaaga tttgaacatc ccgcgtgatg ttagcaggca 362701 tccgctgttt gacacgatgt tcagccttca aaacgcgaca gagggcattc cggctgtcgg 362761 cgatctttcc ttgtctgttc aagagaccaa tttcaagatt gccaaatttg atttgacggt 362821 gcaggcgaga gaaaccgatg aaggcattga gattgatgtg gattacagca caaagctgtt 362881 taaacaaagc acggcagaca ggctgcttac gcattttgcg cgtttgcttg aagatgctgc 362941 ggctgatcca gagaagccga tttctgagta taagcttctt tctgaagagg aggctgcttc 363001 gcaaattcag cagtttaacc cgggcagaac accttatccg aaagataaaa caattgttca 363061 gctgtttgag gagcaagcgg cgaatacgcc agaccacact gcgcttcaat atgaaggcga 363121 atcactcact tatcgtgaac tgaatgaacg ggccaatcgt ttagcccgcg gcattctttc 363181 tcttggagct ggcgaaggca gaactgcggc tgtcttatgc gagcggtcaa tggatatgat 363241 tgtgtcgatc ttggcagtat taaaatcagg ttcggcttat gttccgatcg atccggaaca 363301 tccgattcag cggatgcagc atttcttccg tgacagcgga gcaaaggtgc ttctcactca 363361 gaggaaatta aaggctttgg cggaagaagc ggaatttaag ggcgttatcg tgctagccga 363421 tgaggaagaa agctatcatg ccgatgcgcg aaatctcgca ctgcctcttg attctgcagc 363481 aatggccaac ctgacgtata cttccggaac gactggaaca cctaagggga atatcgtgac 363541 acatgccaat attctccgca cggtgaagga aacgaattat ctcagcatta cagaacagga 363601 tacgattctc ggtctttcca attacgtgtt tgacgcgttt atgttcgata tgttcggctc 363661 tttgttaaac ggagccaagc tggtgctgat accgaaggaa accgttttgg acatggctcg 363721 cctgtcccgc gtcattgaac gggagaacat cagcattctc atgattacaa ccgctttgtt 363781 ccacttgctt gtggacttga atccggcatg cttgtcaacg cttcgcaaga ttatgtttgg 363841 cggggaacgg gcttcggttg agcatgtcag aaaagctttg caaacggttg gaaagggcaa 363901 gctccttcat atgtatggac cgtctgaaag cacggttttc gcgacgtatc atccggttga 363961 tgaattggag gagcacacgc tgtctgttcc gattggaaaa ccggtcagca atacggaagt 364021 atacattctt gaccgtacgg gacacgtgca gcctgccggg attgccggag agctttgcgt 364081 cagcggcgaa ggactcgtga aaggctatta caaccgtcca gaactgactg aggagaaatt 364141 tgttccccat ccgtttacat ccggcgaacg catgtataaa acgggagacc ttgcgagatg 364201 gctgccgaat ggcgacatcg aatttatcgg gcgaatcgac catcaggtga agattcgcgg 364261 acagcgcatc gagcttggag aaatcgaaca tcagctgcaa acccatgatc gtgttcagga 364321 aagtgttgtg cttgccgttg atcaaggagc gggagataaa ctgttgtgtg cttactatgt 364381 cggagaagga gacatctcat cacaagagat gagagagcat gctgcgaagg acttgccggc 364441 atatatggtt cctgcggtgt ttatccaaat ggacgagctg ccgctgacag ggaacggaaa 364501 aattgaccgg agagcgctgc cgattcctga tgccaacgtt tcaagaggtg tttcatatgt 364561 tgcgccacgc aatggaacgg aacaaaaagt cgcggacatt tgggcacagg tacttcaggc 364621 agaacaagtc ggcgcttatg accacttctt tgacattggc ggacattcat tagcaggcat 364681 gaagatgctt gccttggttc atcaggaact gggcgttgag ctgtcactca aggatctctt 364741 ccagtcaccg acggttgagg gcttggcaca ggtgattgcc tctgctgaaa aagggacagc 364801 cgcaagtatc agcccggcag agaaacaaga tacgtatcct gtttcttcac cgcaaaaacg 364861 gatgtacgtg cttcagcagc ttgaggatgc gcaaacgagc tataacatgc cggcggttct 364921 gcgcctgaca ggtgagcttg atgttgaaag gcttaacagc gtcatgcagc agttaatgca 364981 gcgtcatgaa gccttgagaa ccacgtttga aataaaagat ggagaaacgg tgcagcggat 365041 ctgggaagag gctgagtgcg agatagccta tttcgaagcc ccggaagaag agacagagcg 365101 gatcgtttct gagtttatta agcctttcaa aatcgaccaa cttccactgt tcagaatagg 365161 gcttatcaag cattcagaca ctgagcatgt gctgctgttc gatatgcatc atattatttc 365221 tgatggtgca tctgtcggtg tgctgattga ggagctttca aagctgtacg acggagaaac 365281 ccttgagccg ctccgtattc aatataagga ttatgccgtg tggcagcagc agttcattca 365341 gtctgagctt tacaagaagc aagaagagca ttggctgaag gagctggacg gagagctgcc 365401 ggtgctgacg cttccgactg attacagtcg gcctgccgtt caaacatttg agggagaccg 365461 cattgcattt tcattagaag caggcaaagc tgatgctctg cgcaggcttg caaaagaaac 365521 ggattccacg ctttacatgg tgcttctggc ttcatacagt gcgtttttat caaaaattag 365581 cgggcaagac gatatcatcg tcggttcacc tgtggccgga cgatctcaag cggacgtcag 365641 ccgcgtcatc ggaatgttcg tcaatacatt ggcgctgcgc acgtatccga agggtgaaaa 365701 gacgtttgct gactatctta acgaagtgaa agaaacggca ctcagcgctt ttgatgcgca 365761 ggattaccca cttgaggatt tgatcggaaa tgttcaggtt cagcgtgaca caagcagaaa 365821 tccgttattc gatgcagttt tttcaatgca aaatgcgaat ataaaggatt taacaatgaa 365881 agggattcag cttgagccgc atccgtttga acggaaaaca gccaagtttg acctcacgct 365941 gacggctgac gaaaccgacg gagggcttac attcgtactc gaatacaata cagctctgtt 366001 taagcaggaa acgattgaac gatggaagca atattggatg gagcttttag atgcagttac 366061 tgggaacccg aaccagccgc tttccagcct gtcactggtc accgagacag aaaagcaagc 366121 gcttcttgag gcatggaagg gcaaagcgct gcctgtgccg acagacaaaa cggttcatca 366181 gctattcgaa gagactgccc agcgccacaa agaccgcccg gctgtcacat acaacggcca 366241 gtcttggacg tacggcgagc tgaatgcgaa ggcaaaccgt ctcgcgcgga ttctgatgga 366301 ctgcggcatc agcccggatg accgcgtcgg cgttctcacg aagccgtcgc ttgaaatgtc 366361 cgccgcggtg ctcggcgtct tgaaagccgg agcggcgttt gtgccgattg atcctgacta 366421 tccggatcag cggattgagt atattttaca ggacagcggc gcgaagcttc tcttgaaaca 366481 ggaaggcatt tcagtgccgg acagctatac gggagatgtc attcttctcg acggaagccg 366541 cacgattcta agcctgccgc ttgatgaaaa cgacgaggaa aatccagaaa ccgctgtaac 366601 cgcggagaac ttggcgtaca tgatttacac gtctggaacg accggacagc cgaagggtgt 366661 catggtcgag caccatgcgc ttgtgaacct gtgcttctgg caccacgacg cgttcagcat 366721 gacagcggag gaccgcagtg cgaagtacgc gggctttggg ttcgacgctt ccatttggga 366781 gatgttcccg acctggacga tcggtgccga acttcacgtc attgaggaag cgatccgcct 366841 cgatatcgtc cgcctgaacg attattttga aacgaacggc gtaacgatca cgttcctgcc 366901 gacacagctt gcggaacagt tcatggagct tgagaacaca tcacttcgcg tattgcttac 366961 tggaggagac aagctgaagc gcgcagtgaa aaagccgtac acactcgtca ataactacgg 367021 gccgacagag aatacggtcg ttgccacaag cgcagaaatc catccggagg aaggctcgct 367081 ttccatcgga agggccattg ccaatacgag agtatacatt ctcggcgagg gcaatcaggt 367141 gcagccggaa ggcgtagccg gagagctttg cgtggcgggg cgcggactgg cacgcggcta 367201 tctgaatcga gaagacgaaa ccgcgaagcg gtttgtcgct gatccgtttg tgccgggtga 367261 gcgcatgtac cgcaccggcg atttggtgaa atggacgggc ggcggcatcg aatacatcgg 367321 ccggatcgac cagcaggtca aggtccgcgg ctaccggatc gagctctcag aaattgaagt 367381 ccagctcgcc cagctttctg aggtgcagga tgcggcggtg acagctgtca aagataaagg 367441 cggcaacaca gcgatcgcgg cgtatgtcac accggaatca gctgacatag aagcactgaa 367501 atcagcactg aaggaaaccc tgccggatta catgatcccg gcgttctggg tgacgctgaa 367561 cgagcttccg gttacggcaa acggcaaagt ggaccgcaaa gccttgcctg agccggacat 367621 cgaagcggga agcggagaat acaaagcgcc gacgaccgac atggaagagc tgcttgccgg 367681 catctggcag gacgtgcttg gaatgtctga agtcggtgtc accgacaatt tcttctcgct 367741 tggcggagat tccatcaaag gaattcaaat ggcgagccgc ttgaaccagc acggctggaa 367801 gctggaaatg aaagatctct tccagcaccc gacgatcgaa gagctcaccc agtacgtaga 367861 gcgtgccgaa ggcaaacagg cagaccaagg cccggtggag ggcgaagtca tcctgacgcc 367921 gatccagcgc tggttctttg aaaagaactt cacgaacaag caccactgga accaatctgt 367981 gatgcttcac gccaagaagg gctttgatcc tgaacgggtg gagaaaacat tgcaggcgct 368041 gatcgagcat catgacgcgc tccgcatggt ctatcgtgag ggacaggaag acgtcattca 368101 atacaacaga ggtcttgaag ctgcttcagc tcaattggag gtcatccaga ttgagggcca 368161 agctgcagat tacgaagacc gaatagagag agaagcggag cgtttgcaaa gcagcatcga 368221 cttgcaggaa ggcggcttgt taaaagcagg cttgttccaa gcggaagacg gagatcactt 368281 gcttcttgcc attcaccact tagtggttga cggcgtgtcg tggcggattt tactggagga 368341 tttcgccgcg gtatatacac agcttgagca aggcaatgaa ccggttctcc cgcagaaaac 368401 acattcattt gcagagtatg cagagagatt gcaagacttc gcgaactcca aagccttttt 368461 gaaagaaaaa gagtattgga gacagcttga agaacaagct gttgcggcaa agcttccgaa 368521 agaccgcgaa tctggtgatc agcgaatgaa acatacaaag acaattgaat tctcgctgac 368581 tgctgaagag acagaacagc tcaccacaaa ggtgcatgag gcatatcaca cagaaatgaa 368641 tgatattttg ctgacggcat tcggattggc aatgaaggag tggacgggtc aagatcgagt 368701 aagtgttcat ttagaggggc atggacgtga agaaatcata gaagacctga ccatttctcg 368761 cacagtcggc tggtttacaa gtatgtaccc aatggtgctc gatatgaagc atgcggatga 368821 tctgggctac cagctgaagc aaatgaaaga agatatcaga catgtgccga ataagggagt 368881 cggatacggc attctgcgct atctgacggc accggaacat aaagaagatg tggcgttctc 368941 gattcagccg gatgtcagct tcaactattt aggtcagttt gacgaaatgt cggatgcagg 369001 tttgtttacg agatcagagc tgccatcagg acagtcatta agccctgaaa cagaaaaacc 369061 gaatgcgctg gatgttgtcg gatatatcga aaacggaaaa ctgacgatgt cactggccta 369121 tcattctctt gaatttcatg aaaaaacagt acaaacattc agtgacagct ttaaagcgca 369181 tcttctcaga atcattgaac attgcctatc tcaagatggt acggaactga ccccgagtga 369241 tcttggtgac gacgatttga cgctggatga gctggataaa ttaatggaaa ttttctaata 369301 gaggtggcat atgagcaaaa aatcgattca aaaggtgtac gcactgacac caatgcagga 369361 gggaatgctg tatcatgcga tgcttgatcc gcattcttcc tcgtacttca cacaattaga 369421 gcttgggatt cacggcgctt ttgatcttga aatctttgag aaaagcgtca atgaactgat 369481 tcggtcatac gatattctcc gtacggtatt tgtgcatcag cagctgcaaa aaccgcgtca 369541 ggtcgtgtta gcggaacgca aaacaaaagt gcattatgag gatatcagtc atgcagacga 369601 aaaccgccag aaagagcaca ttgagcgtta caaacaagac gttcagcgcc aaggctttaa 369661 cctggcaaaa gacatattgt tcaaggtagc ggttttccgc cttgctgcag atcagctgta 369721 tcttgtctgg agcaatcatc atattatgat ggacggctgg agcatgggcg tcctcatgaa 369781 aagcctgttc caaaactatg aagcgctcag agcaggcagg acaccggcaa acggtcaggg 369841 caagccttat tccgattaca tcaagtggct tggaaaacag gacaatgaag aagcggagag 369901 ctactggagc gagcgcttgg cgggttttga acagccaagc gtgctcccgg gccgcctgcc 369961 tgtgaaaaaa gacgaatacg tcaataaaga atattcattt acatgggacg aaacactggt 370021 tgcccgtatt cagcaaaccg caaatctcca tcaagtgaca gggcctaacc tatttcaggc 370081 cgtttggggc attgttctca gcaaatacaa ctttacggat gatgtgatct tcggaacggt 370141 cgtctcggga cgaccgtctg aaatcaacgg aatcgaaacg atggcggggc tgtttatcaa 370201 caccattcca gtgcgggtga aagttgaacg agatgctgca ttcgctgata ttttcacagc 370261 tgttcagcag catgcagtag aggcagagcg ttacgattac gtgccgctct atgagattca 370321 aaaacgctca gctcttgatg gcaatctctt aaaccatctg gtcgcgtttg aaaattatcc 370381 gcttgatcaa gagcttgaaa acggcagcat ggaagaccgc ctcgggtttt cgattaaggt 370441 agaaagcgca tttgaacaaa cgagcttcga tttcaacctg attgtgtatc cgggcaaaac 370501 gtggaccgtc aaaattaaat ataacggagc cgcctttgat tccgctttta tcgaacggac 370561 agcggagcac cttacccgca tgatggaagc agctgtcgat cagccggccg cttttgtgcg 370621 tgagtacggg cttgtgggag acgaagagca gcggcaaatt gtcgaggtgt ttaacagcac 370681 gaaagccgaa ctccctgaag gaatggctgt tcaccaagtg tttgaagagc aagcgaaacg 370741 gacgccggcg agcaccgccg tcgtatatga aggaaccaag ctgacgtacc gcgagctgaa 370801 tgcagcggct aaccgtctgg cgagaaagct tgtcgaacat gggcttcaaa aaggggaaac 370861 agcagcgatt atgaacgacc gctcagtaga aaccgttgtc ggcatgctgg ctgttttaaa 370921 agcaggcgcc gcatatgtgc cgcttgatcc agcgcttcct ggggatcgtc ttcgtttcat 370981 ggcagaggac agctccgttc gaatggtttt gatcggaaat tcttatacag ggcaggcaca 371041 tcagctgcaa gtgccggttc ttacactgga cataggcttt gaagagagtg aagcggctga 371101 caatctcaac ctgccatccg ccccgtctga tttggcgtac atcatgtaca catccggttc 371161 aacgggcaaa ccgaaaggcg tcatgatcga acataaaagc attctgcgcc tcgtcaaaaa 371221 tgccgggtac gttcctgtta ctgaagaaga ccgcatggcg caaacgggag ctgtcagctt 371281 tgatgccgga acgtttgagg tattcggcgc actgctgaat ggcgcagcac tttatccggt 371341 caaaaaagag acactgcttg atgcgaaaca atttgctgca ttcctgcgtg agcaaagcat 371401 cacaactatg tggctgacat cacctttatt caaccagctt gctgcaaagg atgcgggtat 371461 gttcggcaca ctgcgccatt taatcatcgg cggagatgcc cttgtcccgc atattgtcag 371521 caaagtaaaa caggcatcgc cgtcgctttc attgtggaac ggatacggcc cgacagaaaa 371581 cacgacgttt tcaaccagtt ttctgatcga ccgcgagtat ggcggctcta tcccaatcgg 371641 gaagccgatc ggaaattcca ctgcctatat tatggatgag cagcaatgcc tgcagccaat 371701 cggcgcgcct ggtgagcttt gcgtaggcgg aatcggtgta gcgcgtgggt atgtcaatct 371761 ccctgagctg acggagaagc aatttctgga agacccgttc agaccgggtg agagaattta 371821 ccgcactggt gacttggcaa gatggctgcc ggacggcaat atcgaatttt taggcagaat 371881 cgacaaccaa gtgaaggtgc gcggcttccg aattgagctt ggcgaaattg aaacaaaact 371941 gaacatggct gagcatgtga cagaagccgc ggtgatcata cgcaagaaca aagcagacga 372001 aaatgaaatt tgcgcgtact tcacggcgga tcgtgaagtg gctgtgagtg agctgagaaa 372061 aacactgtct cagtctttgc ctgactatat ggtccctgcc cacctgattc aaatggacag 372121 cctgccgctc acgccaaacg ggaaaatcaa caaaaaggaa ctgcctgcac cgcaatcaga 372181 agccgtgcag ccggaatacg cagcaccaaa aacagagagt gaaaagaaat tagcggagat 372241 ctgggaagga atactcggcg tcaaagcagg cgttaccgat aacttcttta tgatcggcgg 372301 ccattctttg aaagcgatga tgatgacggc gaaaattcaa gagcattttc ataaggaagt 372361 tccgataaaa gtgctttttg aaaagccgac tattcaagaa ctggcactgt atttggaaga 372421 gaacgaaagc aaggaggagc agacgtttga accgatcagg caagcatctt atcagcagca 372481 ttatcctgta tccccggccc agcggagaat gtatatcctc aatcagcttg gacaagcaaa 372541 cacaagctac aacgtccccg ctgtacttct gctggaggga gaagtagata aagaccggct 372601 tgaaaacgcg attcagcaat taatcaaccg gcacgaaatc ctccgtacat cgtttgacat 372661 gatcgacgga gaggttgtgc aaaccgttca taaaaacata tcgttccagc tggaggctgc 372721 caagggacgg gaagaagacg cggaagagat aatcaaagca tttgttcagc cgtttgaatt 372781 aaaccgcgcg ccgctcgtcc gttcgaagct tgtccagctg gaagaaaaac gccacctgct 372841 gctcattgat atgcatcata ttattactga cggaagttca acaggcattc taatcggtga 372901 tcttgccaaa atatatcaag gcgcagatct ggaactgcca caaattcact ataaagatta 372961 cgcagtttgg cacaaagaac aaactaatta tcaaaaagat gaggaatact ggctcgatgt 373021 ctttaaaggc gaactgccaa tactggatct tcccgcggat ttcgagcggc cagctgaacg 373081 gagctttgcg ggagagcgcg tgatgtttgg gcttgataag caaatcacgg ctcaaatcaa 373141 atcgctcatg gcagaaacag atacgacaat gtacatgttt ttgctggcgg cgttcaatgt 373201 actcctttcc aagtacgcgt cacaggatga tatcattgtc ggctcgccga cagctggcag 373261 aacacatcct gatctgcaag gtgtgccggg tatgtttgtc aacacggtgg cactcagaac 373321 ggcaccagcg ggagataaaa ccttcgcgca attccttgaa gaggtcaaaa cagccagcct 373381 tcaagcattc gagcaccaga gctatccgct tgaggagctg attgaaaagc ttccgcttac 373441 aagggataca agcagaagtc cgctgttcag cgtgatgttc aacatgcaga atatggagat 373501 tccttcatta agattaggag atttgaagat ttcctcgtat tccatgcttc atcatgttgc 373561 gaaatttgat ctttccttgg aagcggtcga gcgtgaagag gatatcggcc taagctttga 373621 ctatgcgact gccttgttta aggacgagac gatccgccgc tggagccgcc actttgtcaa 373681 tatcatcaaa gcggccgcgg ctaatccgaa cgttcggctg tctgatgtag atctgctttc 373741 atctgcagaa acggctgctt tgctagaaga aagacatatg actcaaatta ccgaagcaac 373801 ctttgcagca ctttttgaaa aacaggccca gcaaacacct gaccattctg cggtgaaggc 373861 tggcggaaat ctgttgacct atcgcgagct tgatgaacag gcgaaccagc tggcgcatca 373921 tcttcgtgcc caaggggcag gaaatgaaga catcgtcgcg attgttatgg accggtcagc 373981 tgaagtcatg gtatccattc tcggtgtcat gaaggcgggg gcagctttcc ttccgattga 374041 tcctgataca cctgaagaac gaatccgtta ttcattagag gacagcggag caaaatttgc 374101 ggtcgtgaat gaaagaaaca tgacggctat tgggcaatat gaagggataa ttgtcagcct 374161 tgatgacggt aaatggagaa atgaaagcaa ggagcgccca tcatccattt ccgggtctcg 374221 caatcttgca tacgtcattt atacgtccgg tacgaccgga aagccaaagg gcgtgcagat 374281 tgagcatcgt aatctgacaa actatgtctc ttggtttagt gaagaggcgg gcctgacgga 374341 aaatgataag actgtattgc tttcatctta cgcatttgac cttggctata cgagcatgtt 374401 ccctgtactt ctgggcgggg gcgagctcca tatcgtccag aaggaaacct atacggcgcc 374461 ggatgaaata gcgcactata tcaaggagca tgggatcact tatatcaagc tgacaccgtc 374521 tctgttccat acaatagtga acaccgccag ttttgcaaaa gatgcgaact ttgaatcctt 374581 gcgcttgatc gtcttgggag gagaaaaaat catcccgact gatgttatcg ccttccgtaa 374641 gatgtatgga cataccgaat ttatcaatca ctacggcccg acagaagcaa cgatcggcgc 374701 catcgccggg cgggttgatc tgtatgagcc ggatgcattt gcgaaacgcc cgacaatcgg 374761 acgcccgatt gcgaatgccg gtgcgcttgt cttaaatgaa gcattgaagc ttgtgccgcc 374821 tggagcgagc ggacagctct atatcacggg acaggggctc gcgagagggt atctcaacag 374881 gcctcagctg acagccgaga gatttgtaga aaatccatat tcgccgggaa gcctcatgta 374941 caaaaccgga gatgtcgtac gaagactttc tgacggtacg cttgcattta tcggccgggc 375001 tgatgatcag gtgaaaatcc gaggctaccg cattgagccg aaagaaattg aaacggtcat 375061 gctcagcctc agcggaattc aagaagcggt tgtactagcg gtttccgagg gcggtcttca 375121 agagctttgc gcgtattata cgtcggatca agatattgaa aaagcagagc tccggtacca 375181 gctttcccta acactgccgt ctcatatgat tcctgctttc tttgtgcagg ttgacgcgat 375241 tccgctgacg gcaaacggaa aaaccgacag aaacgctctg ccgaagccta acgcggcaca 375301 atccggaggc aaggccttgg ccgcaccgga gacagcgctt gaagaaagtt tatgccgcat 375361 ttggcagaaa acgcttggca tagaagccat cggcattgat gacaattttt tcgatttagg 375421 cggccattca ttaaaaggga tgatgctgat tgccaacatt caggcggaat tggagaaaag 375481 cgtaccgctt aaagcactgt tcgagcagcc gacagttcgc cagctggcgg cttatatgga 375541 ggcgtctgct gtttcaggcg gccatcaagt actcaaaccg gctgacaagc aggatatgta 375601 tccattgtca tccgcacaga aacgaatgta cgtgctcaat cagcttgacc gccagacgat 375661 aagctacaac atgccatctg ttcttctaat ggaaggagag cttgatattt cgcgcctgcg 375721 cgactcactc aatcagcttg tgaaccgtca cgaatcattg cggacgtcat ttatggaagc 375781 taatggtgag cctgttcagc gcatcattga gaaggcggag gttgatcttc atgtgtttga 375841 agccaaagaa gacgaagcgg accaaaagat taaggaattt atccggccat tcgacttaaa 375901 cgacgcaccg ctcattcgcg cagctttgct tcgaatagaa gcgaaaaaac atttgctgct 375961 tttagatatg catcatatca tcgcagacgg cgtctcaaga ggcatctttg taaaagaatt 376021 ggcgctgctt tacaaaggag agcagcttcc ggagccgacg cttcattata aagatttcgc 376081 cgtttggcaa aatgaagctg agcaaaaaga acggatgaag gagcatgagg cgtactggat 376141 gtcagttctt tcaggcgagc tgccagagct tgatctcccg ctcgattatg cccgtccgcc 376201 tgtgcaaagc tttaaaggag atacgatccg tttccgtacg ggaagtgaga cggcaaaggc 376261 ggtagaaaaa ctgcttgccg aaaccggaac gaccttgcac atggtgctcc atgctgtttt 376321 ccacgtcttt ttaagcaaaa tttccggaca gcgggatatc gtcatcggct ccgttactgc 376381 cggccggacg aatgctgatg ttcaggacat gccgggaatg ttcgtcaata cacttgccct 376441 gagaatggaa gcgaaagaac agcaaacatt tgcggagctt ttggagctag caaagcagac 376501 gaacctgtca gcccttgagc atcaggagta tccgtttgaa gatctggtta atcagcttga 376561 tctccctcgg gatatgagcc gaaacccatt gtttaatgtg atggtgacga cagaaaaccc 376621 tgataaagaa cagcttacat tgcaaaatct gagcatttca ccttatgagg ctcatcaggg 376681 aacttctaag tttgatctga cactgggcgg atttactgat gaaaatggca ttggcttgca 376741 gctcgaatat gcgacagatc tgttcgcaaa agaaacagct gaaaaatgga gcgaatacgt 376801 tctgcggcta ctaaaggctg ttgcggataa cccgaaccag ccgctttcca gtctgttact 376861 ggtcaccgag acagaaaagc aagcgcttct tgaggcatgg aagggcaaag cgctgcctgt 376921 gccgacagac aaaacggttc atcagctatt cgaagagact gtccagcgcc acaaagaccg 376981 cccggctgtc acatacaacg gccaatcttg gacgtacggc gagctgaacg cgaaggcaaa 377041 ccgcctcgcc cggattctga tggactgcgg catcagcccg gatgaccgcg tcggcgttct 377101 cacgaagccg tcgcttgaaa tgtccgccgc ggtgctcggc gtcttgaaag ccggagcggc 377161 gtttgtgccg attgatcctg actacccgga tcagcggatt gagtatattt tacaggacag 377221 cggcgcgaag cttctcttga aacaggaagg catttcagtg ccggacagct atacgggaga 377281 tgtcattctt ctcgacggaa gccgcacgat tctaagcctg ccgcttgatg aaaacgacga 377341 gggaaatcca gaaaccgctg taaccgcgga gaacttggcg tacatgattt acacgtctgg 377401 aacgaccgga cagccgaagg gtgtcatggt cgagcaccat gcgcttgtga acctgtgctt 377461 ctggcaccac gacgcgttca gcatgacagc ggaggaccgc agtgcgaagt acgcgggctt 377521 cgggttcgac gcttccattt gggagatgtt cccgacctgg acgatcggcg ctgaacttca 377581 cgtcattgat gaagcgatcc gcctcgatat cgtccgcctg aacgattatt ttgaaacgaa 377641 cggcgtaacg atcacgttcc tgccgacaca gcttgcggaa cagttcatgg agcttgagaa 377701 cacatcactt cgcgtcctct tgaccggagg agacaagctg aagcgggcag tgaaaaagcc 377761 gtacacactc gtcaacaact acgggccgac agaaaatacg gtcgttgcca caagcgcaga 377821 aatccatccg gaggaaggct cgctttccat cggacgggcc attgccaata cgagagtata 377881 cattctcggc gagggcaatc aggtgcagcc ggaaggcgta gccggagagc tttgcgtggc 377941 ggggcgcgga ctggcacgag gctatctgaa tcgagaagac gaaaccgcga agcggtttgt 378001 cgctgatccg tttgtgccgg gtgaacgcat gtaccgcacc ggcgacttgg tgaagtgggt 378061 gaacggcggc atcgaataca tcggccggat cgaccagcag gtcaaggtcc gcggctaccg 378121 gatcgagctc tcagaaattg aagtccagct cgcccagctt tctgaggtgc aggatgcggc 378181 ggtgacagct gtcaaagata aaggcggcaa tacagcgatc gcggcgtatg tcacaccgga 378241 aacagctgac atagaagcac taaaatcaac actaaaggaa accctgccgg attacatgat 378301 cccggcgttc tgggtgacgc tgaacgagct tccggttacg gcaaacggca aagtcgaccg 378361 caaagccttg cctgagccgg acatcgaagc gggaagcgga gaatacaaag cgccgacgac 378421 cgacatggaa gagctgcttg ccggcatctg gcaggacgtg cttggaatgt ctgaagtcgg 378481 tgtcaccgac aatttcttct cgcttggcgg agattccatc aaaggaattc aaatggcgag 378541 ccgcttgaat cagcacggct ggaagctgga aatgaaagat ctcttccagc atccgacgat 378601 cgaagagctc acccagtacg tagagcgtgc cgaaggcaaa caggcagacc aaggcccggt 378661 ggagggcgaa gtcatcctga cgccgatcca gcgctggttc tttgaaaaga acttcacgaa 378721 caagcaccac tggaaccaat cggtgatgct tcacgccaaa aagggctttg atcctgaacg 378781 ggtggagaaa acattgcagg cgctgatcga gcatcatgac gcgctccgca tggtctaccg 378841 cgaggaaaac ggggacatcg ttcaggtgta taaaccgatc ggtgagagca aggtcagctt 378901 cgaaatcgtg gatctgtacg gctccgatga agagatgctg agaagccaga ttaagcttct 378961 cgcgaacaag ctgcaaagca gtctcgatct gcgaaacggg ccgcttttaa aggcggagca 379021 atatcgcaca gaagctgggg atcacctgct cattgctgta caccatctcg tggtcgacgg 379081 tgtgtcatgg cggattttgc ttgaagactt tgcttcaggc tacatgcagg ctgagaaaga 379141 agagagcctt gtcttcccgc aaaaaacaaa ctccttcaag gattgggcgg aagaactggc 379201 ggcattcagc caatcagcgc atcttttaca gcaggctgaa tactggtcgc aaattgccgc 379261 tgaacaggtt tctcctttac ctaaggattg tgaaacagag cagcggatcg tcaaggatac 379321 atcatctgtc ctatgtgaat taacggcaga agacactaag catcttttaa cagatgttca 379381 tcagccatat ggaactgaaa tcaacgatat tcttctcagc gcgctcggtt tgacaatgaa 379441 agaatggaca aagggggcca aaattggcat taaccttgag ggacacggcc gggaggacat 379501 tatcccgaat gtgaatatct ccagaacggt cggctggttt acggcacaat accctgttgt 379561 gctcgacata tctgacgcag atgcctcagc tgtgatcaaa acagtcaaag aaaacctgcg 379621 ccgcattccg gacaaaggtg ttggctacgg cattcttcgt tatttcacag aaacagcgga 379681 aacaaagggc ttcacaccgg agatcagctt caactatttg ggccaattcg acagtgaagt 379741 caaaaccgat ttctttgaac cgtccgcttt cgatatgggg cgccaagtaa gcggagaatc 379801 agaggcgctg tacgcattaa gcttcagcgg catgatcaga aacggccggt ttgtgctttc 379861 ctgctcctac aatgagaagg agtttgaaag agctacagtc gaggagcaaa tggaacggtt 379921 taaagaaaac ctcctgatgc taatccgcca ttgcacggaa aaagaagaca aggaattcac 379981 accaagcgac ttcagcgccg aagaccttga aatggacgag atgggagata tctttgacat 380041 gcttgaggag aatttaaaat aaaacgcaag ggaattacag aaggcgggag cgaaacatat 380101 gagtcaattt agcaaggatc aggttcaaga tatgtattac ctatcgccga tgcaggaagg 380161 gatgcttttt catgccatcc tgaatcccgg ccaaagcttt taccttgaac aaatcacgat 380221 gaaagtaaaa ggcagcttga atatcaaatg tcttgaagaa agcatgaatg tgatcatgga 380281 ccggtacgat gtatttcgta ccgtgttcat tcacgaaaaa gtaaaaaggc ctgtccaagt 380341 cgtattgaaa aaacggcagt tccatataga agaaatcgat ctgacacact taacgggcag 380401 cgagcaaaca gccaaaatca atgagtacaa agaacaggat aagatcaggg gttttgattt 380461 gacgcgggat attccgatgc gggcagccat tttcaagaaa gctgaagaaa gctttgaatg 380521 ggtgtggagc taccaccaca ttattttgga cggatggtgc ttcggcatcg tcgtacagga 380581 tctatttaag gtatacaatg ctctgcgcga acaaaagccg tacagcctgc cgcccgtcaa 380641 accgtataaa gactacatca agtggcttga aaagcaggat aaacaagcat cactgcgtta 380701 ctggcgcgaa tatttagagg gctttgaagg acaaacgacg tttgcggagc aaagaaagaa 380761 acaaaaggac ggctatgagc cgaaagagct gctcttttca ctgtcggagg cggaaacaaa 380821 ggcctttacc gagcttgcaa aatcgcagca taccactttg agtacggcgc tgcaggcagt 380881 ctggagcgta ttgatcagcc gctatcagca gtctggcgat ttggccttcg gtacagttgt 380941 ttcagggcgt cccgcggaaa tcaaaggcgt tgaacatatg gtcgggctgt ttatcaacgt 381001 tgtcccgaga cgtgtgaagc tgtctgaggg tatcacattt aacggcttgc tcaagcggct 381061 gcaggagcaa tcgctgcagt ccgagccgca tcaatatgtg ccgctttatg acatccaaag 381121 ccaggccgat cagccgaaac tgattgacca catcattgtt tttgagaact atccgcttca 381181 ggatgcgaaa aatgaagaaa gcagtgaaaa cggctttgat atggtggatg ttcatgtttt 381241 tgagaagtcg aattatgatc tcaacctgat ggcttccccg ggagatgaga tgctgattaa 381301 gcttgcctat aatgagaatg tgtttgatga ggcgtttatc ctgcgcttga aatctcagct 381361 tcttacagca attcagcagc tcatccagaa tcctgatcag cctgtcagca cgatcaacct 381421 cgttgacgac agggagagag aatttttgct aaccggctta aacccgccgg ctcaagctca 381481 tgaaacaaag cctctgacgt attggttcaa ggaagcagtg aacgccaatc cggatgcacc 381541 ggcgcttacg tattccggcc agaccctgtc ttatcgcgaa ttagatgagg aagcgaaccg 381601 cattgcacgc cggctgcaaa aacacggtgc gggcaaaggc tctgttgtag cgctgtacac 381661 gaagcgctca cttgaactgg tgatcggcat tctcggtgta ttaaaggcgg gagcagccta 381721 tctgccggtt gatccgaagc tgccagagga ccgaatctcg tatatgctgg ctgacagtgc 381781 ggcagcctgt cttctgacgc atcaggagat gaaagaacaa gcggctgagc tgccgtatac 381841 aggcacaacg ctcttcattg atgatcaaac acggtttgaa gaacaggcaa gcgatcctgc 381901 aaccgcgatt gatcctaatg atccggcata tatcatgtac acgtccggca caaccggaaa 381961 gccaaagggc aatatcacca ctcatgccaa tattcaagga ttggtcaagc atgtagacta 382021 catggcattt tctgatcagg atacgttctt gtctgtttcg aattacgcct ttgatgcatt 382081 tacctttgat ttctatgctt ctatgctgaa tgcggcacgg ctcattatcg cagatgaaca 382141 tacgctgctt gatacagaac ggctcacaga tctgatcctg caagagaatg tcaatgtcat 382201 gtttgcgaca accgcactat ttaatcttct cacagatgcg ggagaggatt ggatgaaggg 382261 gcttcgctgt atattattcg gcggagagcg cgcgtcagtg cctcatgtca gaaaagcgct 382321 gcggatcatg gggccgggca agctgattaa ctgctacggg ccgactgagg gaacagtgtt 382381 tgcgacagct cacgtcgtgc atgatctgcc ggattccatc tcctcattgc cgatcggaaa 382441 gccgatcagc aatgccagtg tttatattct gaatgagcaa agccagctcc agccattcgg 382501 ggcggtcggt gaactgtgca tcagcggaat gggcgtgtca aaagggtatg taaatcgtgc 382561 tgacctcacg aaggaaaagt ttatcgagaa cccgttcaag ccgggagaaa cgctttaccg 382621 tacaggggat ttagcgcgct ggctgccgga tggaacgatt gaatacgccg gccgtattga 382681 cgaccaggtc aaaatacgcg gacaccggat tgagcttgaa gaaatcgaaa agcagctgca 382741 ggaataccca ggtgtgaaag atgcggtcgt tgtggcggac cgccatgagt ctggcgatgc 382801 atcaatcaat gcctaccttg tgaaccgaac gcagctttca gctgaagacg tgaaggcgca 382861 cctgaaaaaa cagcttcctg cttacatggt gccgcaaacc tttaccttct tggatgagct 382921 tcctttaacg acgaacggga aagtcaataa acggctgctc ccaaaacctg atcaggatca 382981 gctggcggaa gaatggattg gaccgcggaa cgagatggaa gaaacaatcg cacaaatatg 383041 gtctgaggtt ctcggcagaa agcaaattgg cattcatgac gatttctttg cgctcggagg 383101 gcattccttg aaggccatga ccgccgcgtc ccgcatcaag aaagagctcg ggattgatct 383161 tccagtgaag cttttgtttg aagcgccgac gatcgccggc atttcagcgt atttgaaaaa 383221 cgggggctct gatggcttgc aggatgtaac gataatgaat caggatcagg agcagatcat 383281 tttcgcattt ccgccggttc tgggctatgg ccttatgtac caaaatctgt ccagccgctt 383341 gccgtcatac aagctatgcg cctttgattt tattgaggag gaagaccggc ttgaccgcta 383401 tgcggatttg atccagaagc tgcagccgga agggccttta acattgtttg gatattcagc 383461 gggatgcagc ctggcgtttg aagctgcgaa aaagcttgag gaacaaggcc gtattgttca 383521 gcggatcatc atggtggatt cctataaaaa acaaggtgtc agtgatctgg acggacgcac 383581 ggttgaaagt gatgtcgaag cgttgatgaa tgtcaatcgg gacaatgaag cgctcaacag 383641 cgaagccgtc aaacacggcc tcaagcaaaa aacacatgcc ttttactcat actacgtcaa 383701 cctgatcagc acaggccagg tgaaagcaga tattgatctg ttgacttccg gcgctgattt 383761 tgacatgccg gaatggcttg catcatggga agaagctaca acaggtgttt accgtgtgaa 383821 aagaggcttc ggaacacacg cagaaatgct gcagggcgaa acgctagata ggaatgcgga 383881 gattttgctc gaatttctta atacacaaac cgtaacggtt tcataaatga agtgatgaaa 383941 ggaggagaca gccaatgagc caactcttca aatcatttga tgcgtcggaa aaaacacagc 384001 tcatctgttt tccgtttgcc ggcggctatt cggcgtcgtt tcgccctctc catgcttttt 384061 tgcaggggga gtgcgagatg ctcgctgccg agccgccggg acacggcacg aatcaaacgt 384121 cagccattga ggatctcgaa gagctgacgg atttgtacaa gcaagaactg aaccttcgcc 384181 ctgatcggcc gtttgtgctg ttcggacaca gtatgggcgg aatgatcacc ttcaggctgg 384241 cgcaaaagct tgagcgtgaa ggcatctttc cgcaggcggt tatcatttct gcaatccagc 384301 cgcctcatat tcagcggaag aaagtgtccc acctgcctga tgatcagttt ctcgatcata 384361 ttatccaatt aggcggaatg cccgcagagc ttgttgaaaa taaggaggtc atgtcctttt 384421 tcctgccttc tttccgatca gattaccggg ctcttgaaca atttgagctt tacgatctgg 384481 cccagatcca gtcgcctgtt catgtcttta acgggcttga tgataaaaaa tgcatacgag 384541 atgcggaagg gtggaagaag tgggcaaaag acatcacatt ccatcaattt gacggcgggc 384601 acatgttcct gctgtcacaa acggaagaag tcgcagaacg gatttttgcg atcttgaatc 384661 agcatccgat cattcaaccg tgatcaaaag cggacagctt cggctgttcc gctttttttg 384721 tgttgaatgc caatttctgc atggtataat agtcgaaata ctcaaataaa ggcaggtcga 384781 aacatgcgca cgtctcccag gatgaaatgg tttgtattgc tgtttacgtt tgttttcgcc 384841 atcggaatga actcattcag aaattccttt caatttttta tgctgccaat ggcagacgcc 384901 ttccatgccg acaggtcgct gatttcggtt tctgtcagca tttttatgat cacaaccggc 384961 atcgtccagt tttttgtcgg tttttttatc gaccgtttca gtgtcagaaa aattatggcg 385021 ctgggagctg tttgcatcag cgcaagcttt ttggtgcttc cttattcacc gaatgttcat 385081 gtgttttccg ccatttacgg tgtgcttggc ggaatcgggt attcctgcgc ggtcggcgtg 385141 acgacccagt atttcatcag ctgttggttt gacacacaca aaggtctggc gcttgctatt 385201 ttgaccaatg ccaactctgc gggcctgctg cttctctcgc ccatttgggc tgcggctccg 385261 tatcatgccg gctggcagag cacctatacc attttgggaa tcgtcatggc ggctgttctg 385321 ctgccgctcc tcgtctttgg gatgaagcac ccgccacatg cgcaagcgga aactgtgaaa 385381 aaatcttatg attggcgagg gttttggaac gtgatgaagc aatcccgcct cattcatatc 385441 ctgtacttcg gcgtgtttac ttgcggattt acaatgggaa ttattgatgc tcacctcgtc 385501 ccgatactga aggatgcgca tgtctctcat gtcaacggaa tgatggccgc gttcggggca 385561 tttatcatca ttggcggatt attggcgggc tggctgtcag atctcctcgg cagcagaagc 385621 gtcatgctat ccatcttatt tttcattcgg ctgctcagcc tcatttgcct gctcattccc 385681 attctcggaa ttcatcacag cgacctttgg tacttcgggt ttatcctgtt attcgggctc 385741 agttacacag gcgtgatccc gctgaccgcg gcgtcaattt cggaaagcta tcaaacagga 385801 ttgatcggat cgctgttagg catcaatttc tttatccatc aggttgccgg agctctcagc 385861 gtgtatgcgg gcggtttgtt ttttgacatg actcatggtt atttactgat tgtcgctgtg 385921 tgcatcgtgt ttgtgggttt atcggctgta atagagctgg tgccgttttt agataaacag 385981 aaggcaaaag aaacccacca ttcaatataa aaggatcagc actgtcaatg ctgatccttt 386041 ttaaatttga gtttttttgt ttcggtattt ttaaggataa tctccttgaa tctgttcatc 386101 tcctcttcgg agtgaaaaaa atgtttgggg atcgcaatat attggccact tgatgtattg 386161 accctgaaga tatttttata ttcgaaaaca gctgtaattt catcccaatt gaaaatgagg 386221 tcatattttt tagaacatat acgaattcct tcttggttca gagtatatgt tcttttggat 386281 ttcatccgtt cgttcttctt gtatgctctg gaaaacttca catatagaag aaggaggagc 386341 agcagtgtaa acagaacgga catcacgata atcaacatac tgttcataaa caagttaagc 386401 gcgtcacttc cataaacgat acggggccat ccgttaatga agttaactgc agcaaatatg 386461 gcgcaaaaca atagaaagta aaagcatgat atttttgcga tttgataaaa aaagatttct 386521 cttacatcct taaaagtgat ttctcctgga agattgatac tttcactagc atattgaatc 386581 atacggtaaa cctacacctc taaccatgtt tttcctttta gtctagcata atttctcatt 386641 tttttgcagg cataccaggg cgctttgttt ttttctccag attgatattg ctccccacca 386701 cgccaatcat aatacaaaca gccccggcaa gatgatacca ggccaggctt tcgttgagaa 386761 tcacaaatcc tgcaatcatc gtcacaatgg tagatacatg attaaaagcg ctcattttaa 386821 acgcctcaat tcgcgacagc gtatagttag acagaaatga agtgacaagt gaagacagca 386881 cgcccaaata cacaatggcg agaacgaagc cgggctcccg gaacggcaga aaataagtgc 386941 cgactgttcc cgccgctccg tgacgcacaa gggcgatggc gttgaagacg acaaagccga 387001 tggctgacat gatgtaggtg agctcggtca gcttgaaccg ctgcgtcatt tttctggcag 387061 cagtattgta catcgctgaa gacaaagcgg acaataggat cagcaaagac ccttttaagc 387121 tggctgattc cacgtcaacg cctttcatca caaaaataaa catgacgccg gcaacggata 387181 aaaccgtgaa ccccttttgc gtccacgttg ggcgttcctt taaaacataa gcggcaaaga 387241 ccatcgtgaa aatcggaatg gctgcctgaa taattcccgc ttcagaggag gacgagtaca 387301 caaggccgaa tgcctgaaag ctgaaaaata acgcgggata cagcagggcg agcggcaaaa 387361 tgtcaatgac gtcctttacg cggattgata gctttaccca gccgaataag atcggtacag 387421 tggccgcagc aaacgcaatg gtgaaccgat gcgccaaaat atcaaacggc tctgctgttt 387481 gcagtgcgat ttttacgaat agaaaggata aaccgataat gaacgaatat aaaatagccg 387541 ctatataagc gggggtttgc tgatgtttaa ccataatggg aagggctcct ttacctgaat 387601 tgcagcgccg gtcgctccct ttattgtatg gccgcggtca gaacggtaca atgagaaaaa 387661 caatgaactg taccggtaca aaacaggggg agaaggcatg gagaaatata tgagtctatt 387721 aacgaggata gaggagatga tgcaaagcac ctcatatcaa gaaggagaca ggcttccatc 387781 tatccgtcag ctgtccgccc gctaccaagt cagcaaaagc acagtgatcc gcgcgctgca 387841 ggagctggaa aagcgccacc ttatctattc tgttccgaaa agcggctatt atattgtgaa 387901 aaagtcaggg aaatcaaaaa gcgggcagcc tggccccatc gactttgcca catctgcgcc 387961 ggatcccgat gtgtttccgt atcttgattt tcagcactgc atcaacaaag cgattgatac 388021 atacaaaaac gatttgttta tttatgggac gccaaagggg cttccatcac tcatccgcgt 388081 actccgaaag ctcttggcca ctcaacaggt atttgcggat gaacggcata ttttcattac 388141 atcaggtgtc cagcaggcgt tatccttgct ttgtgccatg ccgttcccaa atgggaaaga 388201 gaagatcgcc attgaacagc cgggctacca tttgatggtc gaacagcttg agacacttgg 388261 gattcccgcc atcggggtga aacgaacgga agaagggctt gatatagcca aggttgagcg 388321 gttatttcaa acagaatcga ttaaattttt ttatacgatg ccgcgcttcc ataacccgct 388381 tgggtgctca ttgtcagagc gtgataaaca ggagcttgtg agactggcag aagcgtatga 388441 tgtctatctc gttgaggatg attacctcgg tgatctggag gaaaataaaa aggcagatcc 388501 gctgtacgca tatgatctgt cctcacatgt catctatttg aaaagcttct cgaaaatgat 388561 gttccccggc ctccgcgtgg gggcggctgt tttgcccgaa gcgctgactg acacgttcta 388621 tgcgtacaaa aagctgaacg acatcgactg ttcgatgatt tctcaagcgg cattggagat 388681 ttacctgaaa agcggtatgt acggcaggca taaggagaaa atcagagatt cttataaaga 388741 gcggtcgctg aggctacatc aagccattcg aactcacagg cagctgggaa gcggacgctt 388801 tacgttctcc agcgggcagg caccctgtat gcacacccat ctggtgcttc ctcaggatct 388861 gcccgcctca agagtgattc atagactgga aaaacaaggg gttctccttg aggcgataga 388921 ccgtcattat ttatcagatt atccgaaaga aaatctatta aaaatcaata tttccaatgt 388981 gaaaacggaa gatattgagc gcggtgtcaa gctgttgatg agccatttat aaaagctctt 389041 cgtacgagac cattgtgata tcctcgggga aatcagggtg tacggcgcat acagccattt 389101 tgtagccggg atcgacctca tacgttttga tatagcatgg ggaatggctg tccggaagct 389161 caatggatac ttgtccgtcc tggtgcaggc gcactgaaaa ggaatcaagc ggaagcgata 389221 agcctttgcc ttccttgttt gataaagctt tctttcattg accatagatg ataaaaatag 389281 tctgtctgct cgtccttgtc ttttgctaaa aggtcgctgt actctgtttt tgaaaagaag 389341 cgcttggcga tctcaaggct gatcggtttc gttttttcga tatctatgcc gatcggctgt 389401 gaatcaaacg cgcaaatgac ccagcgtccg gagtgagaaa tgttgaaatg agcgtcggga 389461 agatcaggga tgcacggctt cccgtattcc tgcgtgctaa agcggatatc ggatttgtcc 389521 aactgatact gcctgcttat gactgagcga acgagcacat ctcccagcag ggtgcggtga 389581 gcatcttctt tatgataaaa tctccggcat ttctcccgtt tttcaggtga tatgaaagac 389641 atgaaccgtt cattttcttc ctgtgaaagc gggcggtcca tataaattcc gtaaatcttc 389701 attctagatc ctccgtctgc aaaagattgt caaaaccatc ctatcatact tccacaagac 389761 tcatatagag gagaaaataa aaaaacaaag ccaaggcggc tttgttttag tgtacaggcg 389821 gagatgcttt cactgcggct gtccgccttg ccacagcata attcagcaac tggattgact 389881 ggggcaatga aaaacgcaaa ataagtccgg tgaggatggc ggtcaaaatg gtgccaaaac 389941 cgatcggtcc gcccatgccc catgccgcaa acaaaatggt taattccatg ccgttccgca 390001 cccattgcac attccagccg gttttttctg taatcagcat catcagtgaa tcacgcggcc 390061 ccgcgccaag gcctgctgat acataaacac cgacgccgta accaatcagc accacgccta 390121 gagagaagac gatgatcgag cctgtgtagg tcgagagggc aggcagaatg aaattgaaaa 390181 aatctataaa tacaccaatg agcaccatat tcaggagggc accaattttc ggccaagctc 390241 tcgtaaacaa tgacgtgaat ccgacgatga gcgctccaat aatgatggac cactggccga 390301 cggtaagccc gaagtgctga aacaggctgt aatgaaatgc atcccacgga ctaatgccga 390361 gtgcttttcc ttctatcgtc agggatacac caaaagccaa aatgatcaaa ccggcaaaat 390421 aaaatgtcca gcgcagaaca agttcttgct tcacgtgagg tcccttcttt cgtaaaaatc 390481 agtcgattgt cattgtagca catctgacag aagggcggaa taggcgaaag gggctcaaca 390541 aaaaaacagg gccgccggag gcgccctgtt tcagcgtgtt ggcaaaccct tgcattcgtt 390601 gtcaggcctg tgcttcggtg ctcacgaatt taacattagc tgtgctccaa tgctcgccct 390661 tcctagactt caaaggtttt caatcacgct gaaaatcaca aaatcctaaa acgaatatcg 390721 ttttaggatt ttgtcaataa tctgaaacag ggcgctgacg ctctgttttt cttattacag 390781 cgggttcaaa atccggttta agaaccgctg tgtccgttct tcttttggtg cggagaaaat 390841 ttgctccggc ggtccctgct ccacgataac gccgccgtcg atgaagatga cttcatccgc 390901 aacctcctgc gcgaacttga tttcgtgggt cacgacgacc atggtccagc cttcattggc 390961 caagtccttg ataaccttca gcacctctcc gacaagctcg ggatcaagcg ctgaggtcgg 391021 ttcgtcaaac agcatgagct caggctgtat cgccagtgcg cgggcgatgc cgacgcgctg 391081 ctgctggccg ccggaaagct ggaacggata taaatccatt ttgtccttca atccgacttt 391141 atcaagaagc tgaatcgctt cttttctgac ttcctctttg ttccgttttt gcacctgaac 391201 agggccctcc atcacgtttt cgagggctgt gcggtgcggg aacaggtgat acgcctgaaa 391261 caccattccg gattttcggc gaagctttag gatatccgcc tgtttcacct ttttggagaa 391321 atcgatggag aaatcatcaa atgcaagctc tccgcgattc gggatctcca gagcgttcag 391381 gcagcggagc agcgtcgttt tccctgaacc tgaaggccca agtatggcga tgacttttcc 391441 tttttcaatc ttcatatcta tcttttttaa aatttcattt tcaccgaatg atttgtttaa 391501 tcctttaacg gtaagcatac tcggaacctc cttatttggc cacgtagcgg tcaagacgcc 391561 gttcgatgac atgctggacg agtgagagca ggaagcagat aatccaataa ataaaggctg 391621 cttcaatata gatcactaaa atttgatcaa gattccgcgc gccgatttcc tgggcttttc 391681 tgaacagctc agcgaccaga atttgagagg cgagggatgt atctttaatc aggctgataa 391741 aggtattgga taatggcggg atcgacacac gaaacgcctg cggcaaaatg acgcggaaca 391801 gcgttttttg atgtgtcatg ccaattgtgt agccggcttc ccattgccct ttcggcacgg 391861 ataaaataga tgcccgaatg atttcagatg cataggcgcc gacgtttaat gaaaaggcga 391921 taactgcgct tggaaatgga tctaatgtga cgttaaaggc cgggaacaga tagaaaatga 391981 tgaacaattg aacgagaaga ggagtgccgc gtattgcgga tacgtatacg ctgaacaccc 392041 atctcaaagg tctcactttc gacattctgg caagcgccgt aatcagcgcc aggatcattc 392101 cgaatataaa ggaaagaatc gtaaggggaa tcgtatagta gattccccct gaaagtatcg 392161 gccagaatga ctgctgcacc agatcccacg ggatcgccgt gccaagcgtc aatgccggca 392221 gattatttag aaacatcttc gccgaaccat tttttagaaa ttttagaaag agtcccgtcc 392281 tctttcattt cttttaatgc tttgttgact tgatcaacaa cctcgccgct tcctttacgg 392341 aacgtgaaat atgttgactg aggctcacct gtttcaaacg cgattttcac gtttttattg 392401 ccagatgttt ttaagtagtt caatacggca agcttatcgt tgtatgtcat atcgacgcgg 392461 ccttgctgga tcatttgaag ggcctgcgcc atgccttcaa cgccttctac tttagcgccg 392521 gcatttgtag ctaatttgtt gtagttgctt gtcagtgatt gagctgacgt ttttcctttt 392581 acatctgctt cagacttaat atcgttgttg tcttttttcg ttacgacaac ggctcttgat 392641 gttgtgtatt tatctgagaa atcatatttg tcttcacgat ctgtttttcc gacttggttg 392701 gcaacaacgt caaaccgttt ggaattcagg ccggcaaaca tactgtccca ttgtgtttcc 392761 ttaaagtcga ctttaagccc gaggcgtttt gcgacttctg tgataacttc gacatcatag 392821 ccagtcagtt tatcagtgtc tttgtcgtgg taagtgaacg gctcatatgt tccttccgtt 392881 ccgactgtga gcacaccttt tttcttaatt gaagcccaaa gatcgccatc tttggcatta 392941 tcttttgact gattgtcatt tcctgctccg caagctgcaa gagctgcaat acttacgacc 393001 atgaataaag ccaataatgc ttttttcatc ttattcccca cttttctggt tgattttatt 393061 gaaataaaaa attagcttac aaatctaaag gataactttt ttttagtatg agtcaagtat 393121 ttggttttca taagacaaaa tcttttaaaa taaatccaaa aattgctgtg ccggtttagg 393181 caaataactg tccgttctcc acatgacagc cggtgtcata atgaagggat tattttcgat 393241 atggacggtg tgaacgtgat ttctcatatg aacgggaatc attgtgacag gcaaaataga 393301 cgcgccgaat ccggatgaca cgaggctgag caaagttgca gagtcgtggc attcacaaac 393361 aatgcgcggc tccaggttca aacgatgaaa ttcattcatg acctgattat agacgccttt 393421 tccgttgaca ggccgcagca ggatcagcgg aaatgaagga atgtccacca tcttaatggt 393481 gtctccgcac ggatatccgg cttcatctga aagcacgagc acacatggaa tgtcatcaag 393541 ctgcttgaat tgtactgtgt cacttttgat cagtgttgtc gtgaccgccg catcgatttg 393601 ccggctttcc agcagttcca acagtgtcgc gggttcattt tcccaaatat taaaggtgag 393661 atgggggtat ctctctttga tctgtgttac tttttcaagc atcagagccg cgcaataaat 393721 cgttgatccc acggcaagtg taccggctac ttcctccttc agctcctgta cctcaatgac 393781 tgcatcttca aacctatgca gaatctcttt tgctcttttt agaaaaacag ctccttcata 393841 tgtaagagtc atttgttttt tcttgttacg gtcaaacaga acaacaccaa gttcgtcctc 393901 cagctgtttg agctgcctgc ttaaaggcgg ctgcgccatg tgaagctttt tggctgcgga 393961 cgtaattttc tgttcttggg caatggtaat gaagtatcga agctggcgaa tatccaaaag 394021 aaagcgcctc cttatcatac cttttaggta ttaattatag atttaataga tatttttcat 394081 atggatatat caggagtatg attgaaatga aagcagaatt caagcgtaaa ggagggggca 394141 aagtgaaact cgttgtcgga atgacagggg caacaggggc cattttcggg gtcaggctgc 394201 tgcagtggct gaaggccgcc ggagtggaaa cccatctcgt tgtgtctcct tgggcaaacg 394261 tcacgatcaa acacgaaaca ggctatacgt tacaagaagt agaacaactg gccacataca 394321 cttactcaca taaggatcag gcggcagcca tttcaagcgg gtcgtttgat accgatggaa 394381 tgattgttgc gccgtgcagc atgaaatctc tcgcaagcat tcgcacagga atggcggata 394441 atctgctgac acgtgcggcg gatgtcatgc tcaaggagag aaaaaaactc gtcctcttaa 394501 cgagagagac gcctttgaac caaattcatc tcgaaaatat gctagcgctt acgaaaatgg 394561 gcaccatcat tcttcctccg atgccggcat tttataatcg gccgagaagc ttagaggaaa 394621 tggttgacca tattgttttt agaacgttgg accaattcgg cattcggctt cctgaagcga 394681 agcgctggaa tgggattgaa aaacaaaaag gaggagcttg atcatggctt atcaagattt 394741 cagagaattt ctcgctgccc ttgaaaaaga aggacagctg cttacagtga atgaagaggt 394801 aaagccggaa ccggatttag gggcctccgc acgggcagcc agcaatcttg gcgataaaag 394861 ccctgcgctc ttatttaaca acatttacgg ctatcataac gcgcgaattg cgatgaatgt 394921 catcggctct tggccaaacc atgccatgat gctgggcatg ccgaaagaca caccggtaaa 394981 agaacagttt tttgaattcg caaagcgtta tgaccagttt ccgatgccgg tcaaacgtga 395041 ggaaacagcg ccatttcatg aaaatgaaat cacagaagat atcaatttgt tcgatatact 395101 gcctcttttc agaattaacc agggtgatgg aggctactat ttagacaaag catgtgtcat 395161 ttcccgtgat cttgaggacc ctgacaactt cggcaaacaa aatgtcggca tttacagaat 395221 gcaagtcaaa ggaaaagacc gccttggcat tcagcctgtc ccgcagcacg atattgcaat 395281 ccatctgcgc caagctgaag aacgcggcat caaccttccg gtcactattg cgctcggctg 395341 tgagccggtc attacaacgg cggcatcgac tccgcttctc tatgatcaat cagaatacga 395401 aatggcaggt gcgattcaag gcgaaccata tcgcatcgtc aaatcaaagc tgtctgatct 395461 tgatgttccg tggggcgctg aagtggtgct tgaaggtgag attattgccg gagagcgcga 395521 atatgaaggg ccgttcggtg aattcacagg ccattattcc ggcggacgca gcatgccgat 395581 tatcaaaatt aaacgcgtct atcacagaaa caatccgatc tttgaacatt tatacttagg 395641 catgccttgg acagaatgcg attacatgat cggcattaac acatgcgtgc cgctttatca 395701 gcagttaaaa gaagcgtatc cgaacgaaat tgtggcagtg aacgccatgt acacacacgg 395761 tttaatcgcg attgtttcca caaaaacccg ctatggcgga tttgcgaaag cggtcggcat 395821 gcgcgcactc acaacgccgc acggactcgg ctactgcaaa atggtcatag tcgttgatga 395881 ggatgtcgat ccattcaacc ttccgcaggt catgtgggcg ctttcgacca aaatgcatcc 395941 gaaacatgat gcggtcatca ttccggactt atctgtcctg ccgcttgatc cgggatccaa 396001 tccatcagga atcactcaca aaatgattct cgacgccact acaccggttg cgccggaaac 396061 aagaggccat tattcacagc cgcttgattc tccgctaaca acgaaagaat gggaacaaaa 396121 actaatggac ttaatgaata aataaggaaa ggatgttcga aatgcataca tgtcctcgat 396181 gcgactcaaa aaagggagaa gtcatgagca aatcgcctgt agaaggcgca tgggaagttt 396241 atcagtgcca aacatgcttt tttacatgga gatcctgtga accggaaagc attacaaatc 396301 ccgaaaaata caatccagcg tttaaaattg atccaaagga aacagaaaca gcaattgaag 396361 ttccggcggt gccggaacga aaggcttgat ccgcgtgaac tgtatgtcag accgtctctt 396421 tgagctgctt gacgggagct gcctgaatga gaagcagcat gaggccttcg ttctgcaaac 396481 agtatcagag gatggctggc cgcatgccgc tatgatcagt gcaggtgaaa tcatcgcgct 396541 gagccgaact gatatccgaa tcgctctgtg gaaaaacaca atgacttcgg ccaacatcct 396601 tcgcacagga aaagcacagt tcacggcgtg gtggaaggga gcggcctatt atgtaaagct 396661 tgaatgcgcg cctttaccgc ctttgaaaga tgccgaatat gaaagagacc gtttttcctg 396721 ccgcatcgtt tcagtgaaag aggacgttgc gaaatacgct gatttgactt caggtgtccg 396781 tatacagctt cacagccctg aagaggtgct gagcagatgg aaaaagaccc tggaagattt 396841 aaaacggtaa tatcgatagc ctgacgccat gcgtcaggct ttttttatat aatgaaaaca 396901 aaagggggcg tgagaaatgg aacgtgcggg gatctgtcac tcggacggct ttgatttagc 396961 ttatcgaatt gagggcgagg gcgcacccat ccttgtgatc gggagtgcgg tttactatcc 397021 gcgccttttt tcctcagata tcaaacagaa atatcaatgg gtctttgtcg accatagggg 397081 atttgctaag cctaagcggg agcttcgtgc ggaggattcg aggcttgatg ctgtcttggc 397141 tgatatcgaa aggatgagaa catttcttca gcttgaggat gttactatcc tgggacattc 397201 cgggcacgct tttatggctt tagagtatgc caggacatat cccaaacaag ttcggaaggt 397261 ggcgctcttt aatactgcgc ctgataacag tgaagaaaga cagcgaaaaa gcgaatcatt 397321 tttcatggaa acagccagtc ttgagagaaa gaaacgcttt gaaaaagaca tcgagaattt 397381 gccgcaggac atcgacaaag atcctgaaag gcgctttgtg cacatgtgta ttcgcgctga 397441 agcgaaaagc ttttatcaag agcggccgca tgctgctgcc ttatgggacg gtgtattcac 397501 gaatatgccg atcattgatg aattatgggg caatacattt gcccggattg atcttcttca 397561 gcggttagct gatgttcgta tgccggtgta tatcggatta gggagatatg attatttggt 397621 tgcgcccgtt tcgctatggg atgctgttga cggtttatat ccccatgttg ataaggttat 397681 ttttgaaaag agcggccatc agccgatgct ggaagaaccg gaagcctttg atcaaagctt 397741 caggaaatgg cttgatcaat aaaaaacagc ccgcagatca acatccgcgg gctgtttctg 397801 attataagac ccctttcatc gcgcgtttga tcaccggcga gagcagcagg agaatgccgc 397861 caagaacgat agaaatcaaa ccgatggtgc cgaagtacat tgtttcagga attttatcaa 397921 acaatccggc tacttgggca ttgatcgctt gggctgctgc gttcgtcaga aaccacatac 397981 tcattgtctg tgcagagaag gcagctggtg ccagtttcgt tgtcacggat aaaccgactg 398041 gagacaggca cagctctcca agcacgacaa gcaggaagct gagaacgagc caaagcgggc 398101 ttacgagtgc ttcttttcct tgcatagcag ggaataccat aatgataaat gacaatccgg 398161 ctaaaataat tccgattgag aatttaactg gtgtagacgg ctgacgtttg ccaagcttca 398221 tccagagcca tgcgaatatt ggcgcaaaaa tgacaacaaa caatggattt aatgattgga 398281 accatgatga ctgaagttcg aatccgccca atgaaagtct tatgcgttca tcagcgtata 398341 ccgcaagaat ggtcgctccc tgttcctgaa tggcccagaa catgacagca ccgataaaca 398401 aaggaacgta agcggcaaga cgggattttt ctgttttgtc cgcttttttg cttgtaaaca 398461 tgatgatgaa ataaatcaca ggaatcaaaa taccgagaat acttacaagg tcaatgaaac 398521 gtttgatcgt cagcacgcct gtttgtacag agataatcac tgcgatcgcc acaatgataa 398581 caccgattcc ggtgccaatt gcagattttt tagacagcgg attcggcaca ttggaacctg 398641 caagcccgag gtttttcttt cttgtcaaag caaatacgat aagtccgaga agcattccga 398701 ccgcggcagc tccgaatccg agatgatagt tgtacttctg tccgagtgtt ccgacaatta 398761 acggcgcgag taaaccaccg aggttaatcc ccatgtagaa aatactgaaa cctgagtcgc 398821 ggcgcgggtc ttctttcgtg taaagatccc caactacgct tgaaacgttt ggttttaata 398881 agcctgttcc gacaatgata agcaccatac tgatatagaa tgctatcgaa ctgcccggat 398941 aggcgagtgc aatgtggccg aacataatga atatgccgcc gtaaaacacg gtgtttgcgg 399001 taccgaatac ccggtcagcg agccatccgc caataatggt ggacatgtat acgagtgatc 399061 cgtaaatcga cataatggca accgcagtgc ccttgtcaaa gccgagccct ccgtttaccg 399121 tctctgtata caaatagtaa agtaagattg ctctcattcc atagtaagag aaacgctccc 399181 aaaattcggt gaaaaatagt gtaaatagtc ctcgcgggtg accaaagaac cctttttgcg 399241 ggacgctttt aatgatactt tcgttatcaa tcgaagccat gtcagccaaa ccctttctaa 399301 aaaaagtgta ttataaaaat catattctta tataatactt gtgtcaatat aatttatact 399361 catttcaaat agttccatat tggaaaaatt ataaatacct aaaaatagtg atttcctcct 399421 aatttttaaa ctttttatcg tgagattttc ttacacaact attcctttat atttttttaa 399481 taaaatttta gagaaatgta caagcagatc gggcctttgt gagtaacatg atagtaatca 399541 tagagaagga ggctcgcaat tggctgaatt catattaaat gcagcggatt tcggtgttcc 399601 tagagatggt aaaacggatt cgacagaacg gattaatcag tgcctcagta cagctgtttc 399661 gaaaggctat catactgtct ggtttccaaa gggaacatat ttaatagacg caacgcttgg 399721 cggagatctt aatcagaggt ttcgaaacgc ggggatcatt gttcccggca accttgagat 399781 tatgatggac cccgaatgta tcatgaaagt gataccgaat agttcgtggg gttattccgc 399841 attttatgta ggcaagcaag agaatataac tatttccgga ggacaaatta tcggcgaacg 399901 ggatgagcat acgtatgcct cggcggggat aaggtcaacc catgaatggg gctttggcat 399961 atgtattgaa ggatgctcga atgttgtcat tgatgatgtg aaaatttccg attttaccgg 400021 cgatgggatc atagtcagcc caaggggatt aaagaccaat caagattatc gaacgtcaga 400081 gcaaattatc atccgccgct gtgaggttcg gcggtcgagg agaaataaca tttccattac 400141 cggatgtgac atggtcacgg tggaggaatg cttgattgaa gatgccggaa cggggaatgg 400201 aacagcgccg aaattcggaa ttgacattga aggatatggc gaaggtgacg ttgattatga 400261 ggaaccgatt aatgtatcaa ttcgcaataa ccactttgtt ggaaacgttt caagttctgt 400321 gaccaatttt aacgggtatg gcattttaat agaaggaaat cactcagaca atacaatcag 400381 ctacggatat gggacgcaaa cagtgatcaa gggcaatatt ctgagacgcc ctgaagacgc 400441 ggcggctgcg ccaagagtcg ggataaccgg actcggtgta tcacaaggaa aagagaccag 400501 tgatgcagtg atcgctggca acctcattac cggattttca actggaattg atgtcagggg 400561 aaagagcgtt cttgtgacga acaacaaaat cagcaacttt gaaaacacag ggatattggt 400621 ttatcagtcc tccgacgtaa aggtagacgg aaaccaaatt caaaacggac tgtctgaaac 400681 aaggcgcagc atcggtcttc gcgcagtgct gtcagatgac atcgcatttc tgaataactg 400741 tctcattcaa gtcgttgacg gtgtgaacgt ttccggcgga aatatgatca ttaaagataa 400801 tctcctgaga aaattcagcc ggggcatttg gattgctcaa gggaacgcgg tgattgaagg 400861 gaatacactg aatcctgacg cgtttgaagc agtgccggaa tcatattctg tttccgtcac 400921 aaacaatgcc ggcgccatca tcaaaaacaa tacatttaaa gagttcaaaa attaccccat 400981 ttattgctcc acaagtgcaa aaacctcaat tatcggcaac cacttagagc gatccccgct 401041 tttggtcacc atctatatca gcgcaggtgt gcatgagatt tttgataata ccatttcagt 401101 caacagaaca gccgggaatc cgattgtgat ttatctcaat ggctctgcag gctctatcat 401161 ctctggaaac accatcaata acctctccgc gggcactgcg acagctattc aaacaaacac 401221 gtcaaccaat tccaaaatca tcggcaaccg catttttaaa gggaccatca acaaacacag 401281 cagtgataca atagacggca atatgattgt ctgaaaaaag cgcccccctt taggggttct 401341 tttttttcga tttatagatc acgtacattt ctctcacaag tactaacaca aaaaataaaa 401401 gcacgaccca ttccgcaaat gttgtcatct taaagctgga catattgtta taaacggctt 401461 ttgttaaact gaacccttga agcatgtcca tcaacacaga aatagctaat aaacaaatta 401521 atatgaatcc ggtcacgccc aatatcttca tgcttcatca tcctccgctt ttagtgtcta 401581 tctttggcgg agaagttata ccgcatctaa ccctaatgca taatctcaat tttaaaagga 401641 agaatatgag aaaacgacaa ggaaaggtat ttgtgtatgc ctttattttc taagcgaaag 401701 aacaataccg attcaaaaga caagcagaat acagacgaaa ggaatcagga acagcagcaa 401761 gaaaaagaaa ggccggttct catttctcca agtttagcaa agaatatagc ggaaacgaaa 401821 aaggaagtcg gaagcagctc tgacgtcatc attcgcgaga ttaaaatcgg ggagcaggat 401881 catgtccacc tagctgttat ctatatttct gggctggtcg ataataacac gatccatgag 401941 tcgttaattg acccattggt acaggatgag tctatccaga atactcatgc gatccagcaa 402001 attcttgaaa aaacgctccc gctgggcggg gtgaaagcgg aaaagagctg ggacaagctt 402061 ttttccgagt taatgcttgg caatgcgctc atttttgctg atggccatga tgaagctttg 402121 atttgcagca ctcaaggggg agagcagcgc tccatccaag agccgagcac ccaggtgtca 402181 ttccgcggcc cgcgccaagg gtttacagag tctctgcaaa ccaatatttc catgatccgg 402241 cgatacatta aaaatccgaa tttatgggtt gaaaaaatga aaaaaggttc tgttacgaat 402301 acggatatcg ctctcatgta cattcaagga atatgtgatg aaaaggtgct gaaggaagtg 402361 aaacagcgcc tggaaaaaat agatattgac agtattttgg aatctggata tattgagcag 402421 ctgattgaag atgaaacctt tacgacgttt ccgactatgt atcatacaga acgccctgat 402481 gttgtagcgg gtaatctgtt agaaggaaga ttcgcgatta ttgtggacgg aacaccgttt 402541 gtgcttattg ccccagcctt atttgtccag ttttttcagt ctgttgagga ttattattcg 402601 cgttttgaca ttgcgacaag cataagaatt cttcgtgttt tagtcttttt catttcgctt 402661 gtggcaccag ctgtatacgt ggcagccacg acgtttcatc aagaaatgat accgactcag 402721 ctgttagtgg tcattgcggc ccagcgggaa attgtcccgt ttccggctgt tgtggaggcg 402781 ctgacgatgg aggttgcttt tgagattctg agggaagcgg gagtcaggct gccccgggtt 402841 gtcggctcgg cagtgtcaat cgtaggcgcg ctcgtaatcg gccaggctgc cgtacaggct 402901 ggtatcgtct ctccggcaat ggtgattatc gtggcactca ccgcgattgc gagcttcgca 402961 acaccggcgt ttgcaatggc gatttcagcc cggcttattc ggtttatctt tattattgcc 403021 tcagctgtta tgggttttta cgggctgatt ttagggatca ttatgatgtt tgtccactta 403081 tgcagtcttc gttcattcgg cgttccatat atgtcgccgc ttgcaccttt ttcttcacaa 403141 ggcgtaaagg acgcgctttt ccgggttccg tggtgggccg atgaaaaaag gccggaatcg 403201 gtcagcaagg aagataaggt gcggcagggg aaagatcaac gcccagagcc ggccgcttca 403261 cgaggaatgg tgaacaaaga tttggaagaa ggggatcaga atggtacgta aatgtctatt 403321 agccgttctc atgcttttga gcgtcattgt gctgcccggc tgctgggata agcgggagct 403381 gacggatctt gcgattatct cggcgattgg catcgatcgg acaaacgaca gcaactacgt 403441 gctgcatctt caaattatca atccaggaaa tgttgccggc ggccttcagg gaggcggtgc 403501 tggagacagg ccgcctgtat ctgtctattc gattgaaggt aacaatataa cggaagcact 403561 cagaaaagcc tccatgaagg tatcacggcg gctttatttt gcccatacca atctagtcgt 403621 gatcaatgaa aagctggcaa aagaagaagg tttggatttt gtattagata atcttgaccg 403681 ggacacagaa ttcaggacaa cagcaacatt cgtcgttgcc cataaaacaa aagcagaaaa 403741 tattgtgaaa atcttgacgc cgattgataa aattccgtca aataaagtca ataaaacact 403801 cgatttcacg gaggcacaat acgggcgggt ggtcaaaatc aatattcagg acgttttgaa 403861 aacacttgcc gccaacacta tggcaccggt catccccgga tatatgatga ttggtgacga 403921 taaaaaagga gtcagcatgg aaaacacgca ggcgactgac ccgaaagcca ttcttcaggc 403981 agatggtttg gcggtttttg ataaggcagg atatttaaag tattggctgg aagatgatga 404041 aagcgtgggg gcagtctggc ttatgaataa gatccagcat acgtttatta atgctgactg 404101 gggcaagacg aaggatgcgg tcagcttgca ggttacccat caagatacaa agctggtacc 404161 gaaaatgcgg aacggacgcc cgtacatcca tgtgaaagtg tcggttgaag gtattataga 404221 tgctgtcaaa taccctttcc aattgtctga tcccaaggtg ctggccgcta ttgaaaaagc 404281 gctcaacaaa gagcttgaaa aggaaatcag ccatactgtg aaaaagatta agaagaataa 404341 aatagatttt atcggttttg gtgacacgat atatagaaag tatccggagc agtgggagaa 404401 aatgaaggac acttgggaca aagaatattt gccggaactg cccatcgatg tgaaggccga 404461 gacgtatatc agaaggacgg gattgcgaaa caatccgatc aaacaccagt ttaaagatga 404521 ttaggtctga agaaagggga agtgacagat ggaaaaagcc agaataagca taaggcagtt 404581 gtttgtcatg attatcattt ttgaactggg cagctcctta ttgattacac cgggatcaat 404641 ggcgggcagg gatgcttgga tagcagtttt attaggctgt gcgatcggac tgtttctttt 404701 ctatttgtat caaggcattt atcaatgtta tccgaattct tctccgaaag aatatatgga 404761 tgatatgctg ggaaccaagc tgagctggct gttttcattt ctctatatct tgtactttgc 404821 ctatattgcc gcaagggtgc tgcgtgactt tggagaaatg ctgctgacgt ttgcttatca 404881 tgatacacct atcattattg taaatgcttt attaatggta gtaagcatat atgccgtaag 404941 aaaaggaatt gaagtactcg cacgcgcggc cgaacttctt ttcggggcca tgtatttact 405001 gggcgcgatc ggccttgtgc tgattattgt ctcagggact atagacccgc acaatttaaa 405061 gccggttttg gcaaacggca tttctcctgt ccttcactct gttttcacac agaccatgta 405121 cgttccattt ggtgaagttg ttttatttgt gatgattttc cctaacctga atgacagaaa 405181 agatgtgaaa aaaatgggga tgatcgccat ggctattagc ggattgattg tggcgctcac 405241 cgtggcgatt aatattagcg tgcttgatgt tgatcttaca ctcagatccc agtttccgct 405301 tttaagcacg atccagacaa tcaaggtcga agaattttta gaccggctcg atgtcttttt 405361 tatgctggcg ctgatcatcg gcggcttctt taaggtcagc ctctacttat atgccactgt 405421 ggttgggaca tctacgctct ttaaggaaaa gaacccctct caattggctt atccgatggg 405481 attgggcatc ttaatccttt ctataacgat cgcgactaac ttttcggagc acttgaatga 405541 aggcctgaac gtggtgccgc tgtatattca tttgcctttt caattattgt ttccgctctt 405601 tctgtttatt gtggccgttt ggaaaaagaa acgaagagag aagtcaaaag gggaggaagc 405661 aaaaaaatga taaaaagagc ggggggatgc ggccgccgct ctttttatgt tcacttctat 405721 ataaaagggg gatatagggt gcgcccctgt ctgcactggc agaggcgcgt tttgttatac 405781 gactgcgacg ttttccttca cagtaaaact tcctcttgaa agtctgatat tgatgtctga 405841 cacttttgca atttgttcat cgtgcgtcac cataatgacg catttatctt ccttgtgcgc 405901 cagatcctga aagagccgta cgatctcttt tgatgtgtcc tcatcaaggt ttccggtcgg 405961 ttcatcggct acgataagat ccgtgtcaca gcagaaagcc cttgtaattg atacccgctg 406021 ctgctgtccg ccgctcagtg tgagcacttt ttgccgggct tgtttttcgt tgatgccaac 406081 cttctgcagc atgtcaagcg catatgattc tttgttcttt tctttagaac ctgtgatttc 406141 catagcggtt gtgacgttct gcaaagccgt catatacggg agcaggttgt acgcctgaaa 406201 gacgattgat acatattgat ttctgaaatt ggttaagccg attttagaaa ccgcttttcc 406261 gtcgtaaagg atgtttcctt cttttggtgc gtcaagtccg cctgccagag acaggaaagt 406321 ggttttcccc gtccctgatg ttccgacgat tgtgtagaat tttccttttt gaaagctgat 406381 gttaatatcc tgaaacaatg gctggctttt gtttttatac cagtagccga cttgttgaaa 406441 ttgtaataag ctcataggtt ccgcctcttt ctattcctgt tttgtcaata tcgttttcgg 406501 atgaagccgc agtactgaaa ttgacggcag caatgttgca atgattgcga ttaggatgcc 406561 gatcccgcca agtataagca tgtcgttcat agaaaccgcg acgttcagtg aatcgataac 406621 gtccacgttg gatgaactgt ggccgaacat tttgccgccc atgccgccac cgccgccggg 406681 catttgtccg cttgcggttt gcgttgaatc ggttgatgaa ctgatttgct gggataaaag 406741 ctgatttcca agctgattcg cgacgagatt tcccgtcaca gatgcaaggc cgatagcgat 406801 aacggccaca atcagaatct cagtcaagaa ctgtccaatc aatttccatc gtttttcacc 406861 gatggccatt aacacgccca tttcgtattt gcgctccctg attgacatca tgacaatcag 406921 gccaagaatg acggcgcctg ccactgatac aagatacacc acgtttttag agaaagaagc 406981 cacattttca atcggtccga ccatttgctg gtaaagctga tcgtttgtat tcagtgtgta 407041 cgtatcaaag tcaattgatg ttttcttcgc tgcttttacg aaagtatcca tatttttcgc 407101 gtcgtccata tagtaaacag ctgagtcaat cgtattttta tagtcgtcgc ctttcaatgc 407161 cgctgttgct gtgtaaggcg tataaagctt gttataagga tttaagaaag agaaattttg 407221 ggcttggtca tcacctgaag atgttgtttt ataaataccg acgatcttca gttttactgt 407281 tgtatcctca tccgttgctg attcaattgt gatcgaatcg ccaacgctta aatcattttc 407341 ttccgctaat gtttcgttga tcactgttac ttttttgccg acatctgatt ttgtaatcgc 407401 gcgtccgtct gtgatttttg aatctccgtc agagaaatca tcgactaacg ctgtgctgat 407461 gacaccttca atagaaagat cagcttgaac catttgcggt ccgccttgtc ctccgccttg 407521 actgttttta gcgtttgagc ttgaactgct ggagctggaa tcacttgaac tagagctttc 407581 aatcgcatca aagtttcccg cgttggctga agctgatgtg gtgtaattgt agctcttcac 407641 atgatcaagc gctgcaagct tattcgcatc agacactttg atcggtgtgg attcgaagct 407701 gcgcttttca ccgctgtcct gctgtttttc catttgcttt tggcggtcaa cctgaagtgt 407761 cacgcttcca ccgagttcct gtctggccag ttcgcttgac ttttgtgctg ccgactggat 407821 ggcgaggcct gatagaacaa agacacatat gactgtaaac acaaataatt gcaataacgt 407881 ttttcccttt ttagccttca tattccaaaa ggcccgtttg ataaagttca tttatgttcc 407941 tccgtatagg tatttttatt gataagaccg cctctggggc gcgtcccctt gctgataaat 408001 taatagtagt ccaaaggtat gaaaaaaata tgaacaatct atttctagtt gatgaaataa 408061 aaactaacaa ttgtgaaacg caaaaccttc tgtttaaaat ggtgctatta tataaaaaag 408121 catcaaaaca accggaggat ataatgaaaa tattaatgat agaagataat gttagtgtat 408181 gtacgatgac ggagatgttc ttttttaaag aaggttttga agccgaattc gttcatgacg 408241 ggttagaagg gtaccagcgt tttacggaag aaaattggga tctaatcatt ttggatatca 408301 tgcttccatc tatggacggc gtgaccatct gcagaaaaat aagagagaca agcacggtgc 408361 cgattatcat gctgactgcc aaagacactg aatcagatca ggtcatcggt tttgagatgg 408421 gggcggacga ttatgtcaca aagccgttca gcccgctgac attggttgcc cgcatcaaag 408481 ccgtcatcag aagatataag gcgacaggca aagcggttat tgatgaagat atgattgaaa 408541 cggaatgctt taccattaat aagaagacga gagaagtatt attaaacgga gagcctgtag 408601 aaaatctcac gccgaaggaa ttcgatctgc tttattacct tgtccaaaat ccgcggcagg 408661 tgttctccag agaacagctg cttgagcagg tatggggcta tcaattttat ggagatgagc 408721 gaacggttga cgttcatatc aaacggctgc ggaaaaagct tgccagcgag gacaagcctt 408781 tcctgtatac tgtgtgggga gtagggtata aatttgatga agattaaata tttatatcag 408841 ctgctgctaa gccatatcag cattttgatt ttagcgtttg tcattatcat ttctctgttt 408901 tcccactttg tgaaggaatt tgcctatcag aacaaagtag aggaattgac gtcatatgcg 408961 gtgcagattg caaatgaatt ccaatccggc caggtggaca tgcgcaggct ctatccttat 409021 caggacattt taagcacaag aaagacgcaa tttatcatct ttaatgaaga gcagcagcct 409081 tattttcttc ctgaaggctt tcatcaccca ccaagggaac agctgaagaa atcagaatgg 409141 aataagctga aaaaagggca gactgtcacg atcagggcag atggccgttt tgatgatgaa 409201 gtgtcccttg tggcgcagcc tatatttgtt cagaacgaat ttaaaggcgc cgttctgctg 409261 atttctccga tcagcggtgt tgaacagatg gtcaatcagg tcaacctcta tatgttttac 409321 gctgtgatca gcacgcttgt gattacgatt cttgtgagct ggcttctgtc caaattccat 409381 gtcaagcgga ttcaaaagct gagagaagcg acagataaag tggcttccgg cgattatgac 409441 atccatttgg aaaacagcta cggggacgaa atcggcgtac tggcgtctga ctttaatatc 409501 atggcgaaaa aactaaagca gtcaagggat gaaatcgagc gccttgagaa gcggagaagg 409561 cagtttatcg ctgacgtgtc acatgaatta aaaacaccgc tgacgacgat caacggtttg 409621 gttgaagggt tgaacagcca tacgattcct gaggataaaa aggataaatg cttctcgctg 409681 atcagtgagg aaacgaagcg catgctgcgg ctcgtaaaag aaaatctgga ttatgaaaaa 409741 atcagatccc agcaaattac cttgaacaag ctagacgttc ctctgatcga ggtgtttgaa 409801 atcgtgaaag agcacttgca gcagcaggcg gaagaaaaac aaaacaagct gatgatccaa 409861 gtagaggatc acgtcatcgt acatgccgat tatgaccggt tcattcaaat tctcgtcaac 409921 attacgaaaa acagcatcca atttacgcaa aacggtgaca tttggctgcg cggaatggaa 409981 ggttataaag agacgattat tgaaattgaa gacacgggta tcggcattcc aaaagaggat 410041 attgagcata tttgggagcg attctataaa gcagatattt caagaacgaa cacagcatac 410101 ggtgaatacg gactcggtct ctcgatcgtc aggcagctcg ttgaaatgca ccagggcaca 410161 gtagaaatca agagtgaaga agggaaaggc acaaagttca tcatccgcct tcctttaacg 410221 gcaaaacagc aatagcatac agggcggcgc atcaactgat gcatccgcct tttttgcaca 410281 ccgcttcggt ttattgcgtg ctcccgaaaa caaagattgc gtgtttttcg ggttgggacg 410341 gcctataaac atgataaaat atgacataaa cagtttttga tgggagaggg tgaaggaatg 410401 aagagtgggg taattccttc ttcagcggtc ggtcaaaaaa ttaacgagtg gtacagatat 410461 atccggacat tcagcgtgcc ggatgccgaa gtgttaaaag ctgaaatcca gcaggaactg 410521 aaacacatgc agcatgattc caacttgctg ctttattatt cactaatgga attccggcac 410581 cagcttatgc tggattatct tgagccgtta gagaaattaa atatcgaaga ccagccaagc 410641 ctgtctgaat tatcaagaaa cattgacagc aaccaggcag atctcaaagg gctgctcgac 410701 tattacgtga atttttttcg cgggatgtat gaatttgata agcgggaatt tatttctgcc 410761 attacatact ataaacaggc ggagaaaaag ctctcctttg tcgcagacca tattgaacgg 410821 gctgaattct attttaaaat cgcggaagct tattattata tgaagcaaac gtatttttca 410881 ttgattaata taaaaaacgc ctatgaaatt tacgtggagc aggaaaccta taatgtgaga 410941 atcattcagt gccatttcgt cttcggggtc aacctgatgg atgaaagaaa tttcgaacaa 411001 gccgcacgcc atttcaaatt ggcgctcaac atggcccaag cagaacaaaa agcccagctg 411061 gttggaagag catactacaa tctcgggtta tgctattaca atcaagacct tctagaccct 411121 gccattgatt actttgaaaa agcggtctcc acatttgaaa gcagcaggat cgtcaattct 411181 ctcccgcaag cctatttttt aatcaccctg atttattata aacagggaaa acatgataaa 411241 gcttcggaat atcacaagcg gggctatgaa tatgctaaag aaacagacga tgcagactat 411301 gccgtaaaat tcgagttttt gcaatcccta tatctggatc agcccaatga agaaggaatc 411361 gaacgatgtt tccagtactt aaaaaataaa aatatgtacg ctgatataga ggatttagcc 411421 ctagaagtag caaaatatta ctatgaacag aaatggttta aactgtctgc ttcctacttt 411481 ctacaagttg aagaggcaag aaaacaaata caaaggagtg aaggtttgta tgaaattgaa 411541 atctaagttg tttgttattt gtttggccgc agccgcgatt tttacagcgg ctggcgtttc 411601 tgctaatgcg gaagcactcg actttcatgt gacagaaaga ggaatgacgt aagaacaagc 411661 cccttctcat tagcgagaag gggtttttct tttcaaaaaa acaccgcaag acatagtctt 411721 gcggtgccgc cttcatggag attacgttta tttagtagcc tcctacaaat gcagttccca 411781 caatgatcaa gaggataaat aacacaacaa tcaaagcgaa agaagttccg taacctgaca 411841 ttttgtgcac ctccttgcga gattgcttca gcaaatgctg caaaactgtg gcggacaggg 411901 tcccgcagag acggtcagca gcttagaagc cgccaacaaa cgcagtccct acgataatta 411961 atagaataaa caatacaacg attaaagcga aagaactgat gccgccgtaa ccgccgccgt 412021 tagagtatcc tgacataagg tttcacctcc ctatgaagga tactataaga tatgctgaac 412081 cgatccattt ggcagggata atagtggaca agagaaaaaa tgaagaattc ggctatatga 412141 aggtgatata aaaaaatagc gggcgctgcc gcccgctatt tatgtacgat taagagatca 412201 gcacgcccgc gaaaaattcc tggtataacg cttgaacggc ttttctttct tcggcttctt 412261 ttacgccaaa catcatgctc acttcagaag acccctgatt gatcatttcg atattcacct 412321 gtgcctctga taatgctttg gcggctcttg ccgttgtacc gacattgtgg cgcatcgctt 412381 cccctacaac cataatcagg gcgagatgat gctcgacgat gacttcatcg gcatgcaaat 412441 cctcttcgat ccgtttgatg acgctgcgtt cagtggcggc atccatttgc ccctgccgta 412501 aaatgattgt catgtcatcg attcccgatg gaacatgctc atacgtcaaa ccatgctcct 412561 ccaggatttg aagggctctg cggccaaaac cgatttctct gttcatgaga tacttgctga 412621 tataaatgct gcaaaaaccg gtgtcgctgg caatgccgac gacaggcccg tttgtgttat 412681 cccgcttgct gacgacgcgg gtgccttcgg ctgaggggtt gttcgtattt ttgatctgaa 412741 caggaatccc cgctctgaat gccggaatga gcgcttcatc atgaaacact gaaaaacccg 412801 cgtaggacag ctcccgcatc tctctatatg tcagctcgct gatttccttt ggattctcaa 412861 cgaaggacgg attgacagaa tacacagcgt ctacgtctgt aaagttttcg tacaaatcgg 412921 cttgtagtcc gttggcaaga atcgaaccgg taatatcaga accgctccgt gagaatgtga 412981 tcacatcgcc atccttgctg aatccgaaaa aaccgggaaa aatgatgagt ccgtcacgtt 413041 cccgaagacg atagaggttt tgataggatt caggaagaac ttgcgcgttg ccgggttcat 413101 ttgtcacaaa gaggccggca tccttcgggt ttacatattc cgctttgacg cctttataac 413161 ggaagtaagc ggcgatcagt ttggcattgt tatcctctcc gctggccttg actgcgtcaa 413221 ggtattgttc gggattgctt ttgtctcctt ctaaaagcgt aaacagatca tctctgattt 413281 tttcgataat gctttgcccc agctgaagct cattggcgat gagagcgtac cgttccacaa 413341 cagcttccgc cagttcaggt gcgctgcctg ttgccaaata ttgttctgca catgcgatta 413401 agagatcagt cactttcgta tcctcggcat agtgttttcc cggagctgaa acgactacag 413461 ctttccgtgc cggatctgag gtaacgatgt gaaacacctt gtcaagctgg gcgcctgaag 413521 caagtgagct gcctccgaat ttaacgacct tcatgtttac atctcctaat gtttaaaatt 413581 ttcacacaaa tttagtattt attatctctc tttcagtact gtaaatcaag ggggaatttc 413641 tttctcagga gaacatttgt atttttcacg aggaataatg ttaggtttgc tgaccgtatg 413701 cctgcgttat aaagataaat atggtaaaca gcctaacgtt ttgggatgga aaatggttag 413761 aatgattagt aaaattgata aatgactagg ttaatatttt taaagaatat tgactaaccc 413821 tataaaaatg gtaatatgta aatgataatg ataatcaatt actatatggc catattgttt 413881 tgagtccttg cggagtagga gatacgttct ttttgctgta aggatgtaag gaggcagcat 413941 gaagctacgt tacttattta ttctacttat catattagca gtcacatctg tatttatcgg 414001 tgtagaagat ctgtcgccgc ttgatctctt cgatttaagc aaacaagagg cgtcaacgct 414061 gtttgcaagc cgtttgccgc gattgatcag cattgtcatt gcgggattaa gcatgagcat 414121 ctgcggtttg attatgcagc agatcagcag aaataaattc gtgtcaccga cgacggcggg 414181 cacgatggat tgggcgaggc tcggcatttt aatttccttg ctgctgttta catccgccag 414241 tcctttaatc aaaatgctgg tcgcgtttgt ctttgccctt gcaggaaatt ttctgtttat 414301 gaaaatcctt gaaagaatca agtttaacga caccatcttt attccgcttg tcggtttaat 414361 gctcgggaat atcgtcagtt caatcgcgac atttatcgca tataaatatg acttgatcca 414421 gaatgtgtca tcatggctgc agggagactt ctctttagtc gtgaaaggaa gatacgagct 414481 tctttatctg agtattccgc tcgtcatcat tgcctatgtg tatgcggata aattcacatt 414541 ggccggtatg ggtgaaagct tttctgtcaa cctcggcctc aagtataaac gggttgtgaa 414601 catcgggctc attatcgtgt ccctgatcac gtctcttgtc attttgactg tcggtatgct 414661 gccgtttctc ggtttaatca tcccgaatat tgtatcgatt tacagaggag acaatctgaa 414721 gagcagcctg ccgcatactg tgctgttggg agcggttttt gtgctgtttt gcgatatact 414781 gggcagaatc attatcttcc cttatgaaat ctcgattggc ctgatggtcg gaatcatcgg 414841 cagcggcatt ttcctgttta tgctgttaag gagaaaagcc tatgcgtaac cagatgaaaa 414901 tagctttgct cgttggttta gccattgtat gtattggctt gtttttgttt tatgacttag 414961 gcaattggga ttacaccctg ccgagacgaa tcaaaaaagt cgctgccatt gtgctgactg 415021 ggggagcgat tgcgttttcg accatgatct ttcaaacgat tacgaacaac cgcatcctga 415081 cgccgagcat tttgggcctt gattctctct acatgctgat tcagactggc attatctttt 415141 tgttcggttc tgcgaatatg gtcatcatga ataaaaacat caactttatc atctctgttc 415201 tgctgatgat cctgttttct cttgttttgt atcagatcat gttcaagggt gaggggagaa 415261 atatcttttt ccttctgctt atcggaatcg tgtttggcac gctgttcagc agcctgtctt 415321 cttttatgca gatgctgatt gatccgaacg agttccaagt tgtgcaggac aagatgtttg 415381 ccagctttaa caatatcaat acggatttgt tatggctcgc gttcatcatc ttcctgctga 415441 caggcgttta tgtctggcgt tttacaaaat ttttcgatgt gctgtcgctc ggacgcgagc 415501 acgccgtgaa tttgggcatt gactacgaca aagtggtgaa gcagatgctg atcgtggttg 415561 cgattttggt ttctgtttca acagcgctag tcgggccgat tatgttttta ggccttctgg 415621 tcgtcaacct ggcgagagaa ttcctgaaaa catataagca ttcatactta atcgcaggct 415681 ccgttttcat cagcatcatt gcgctggtcg gagggcagtt tgtggttgag aaagtgttta 415741 ccttctcaac gacgctgagc gtcattatta attttgccgg cgggatttat tttatctact 415801 tgctgttaaa ggagaataaa tcatggtaga ggtcagaaat gtaagcaaac aatatggcgg 415861 gaaagttgtt cttgaagaga cgtcagtcac gattcaaaag ggcaaaatca cctcgtttat 415921 cggtcctaac ggcgccggca aaagtacgct gctgtctatc atgagccgcc tgatcaaaaa 415981 ggattccggc gagatttaca tagacggaca agagattgga gcatgtgaca gcaaagagct 416041 tgccaagaaa atgagcattt tgaagcaggc gaaccaaatc aatatcaggc tcacgatcaa 416101 agacctcgtc agttttggca ggtttccgta ctcacagggc cggctgacag aggaagactg 416161 ggttcatatc aaccaggcgc ttagctatat gaagctggaa gacattcaag acaaatactt 416221 ggatcagctg agcggcggac agtgccaaag ggcatttatc gccatggtca ttgcccagga 416281 cacagattat atctttctgg atgaaccgct gaacaatctg gatatgaaac actcagttga 416341 aattatgaaa ctgctgaaac ggctggtaga ggagcttgga aaaacgatcg tgatcgtcat 416401 tcacgatatc aattttgctt cagtctattc tgactatatc gtcgctttga aaaacggccg 416461 aatcgttaaa gaaggaccgc ctgaagaaat gatagaaaca tcagtgcttg aggaaatcta 416521 cgatatgacc atcccgattc agacgattga taatcaaaga ataggtgttt atttttctta 416581 atatatagaa gaggtgagga gcatgaaaaa gttcgcgtta ctattcatcg ctttggtcac 416641 tgccgttgtc atttctgcat gcggaaacca aagcacaagc agcaaaggtt ctgatacaaa 416701 gaaagaacaa atcacagtga aacaccagct cgacaaaaac ggcacaaaag taccgaagaa 416761 ccctaaaaaa gttgtcgtat ttgactttgg aagcttagat acattagata aactaggact 416821 tgatgatata gtagcgggcc tgccgaaaca agtccttcct aaatatctgt ccaaattcaa 416881 ggatgacaaa tacgctgatg tcggcagctt aaaagagcca gacttcgaca aagtggcaga 416941 attagatcct gatctgatca ttatttcagc aagacaatct gagtcttaca aagaattctc 417001 taaaattgcg ccgacgattt accttggtgt agatacagcg aagtacatgg aatcatttaa 417061 atcagacgct gaaacaatcg gtaaaatctt tgataaagaa gacaaagtga aagatgagct 417121 cgcaaacatt gatcactcaa tcgcagatgt aaagaaaacc gctgaaaagc ttaacaaaaa 417181 cggtctcgtc atcatggcga acgatggaaa aatcagcgcg ttcggcccta aatcaagata 417241 cggcctgatc catgacgtat tcggcgtggc tccggctgat caaaacatca aagcgtctac 417301 gcacggacaa agtgtttctt acgagtacat ttcaaaaaca aaccctgatt acttgtttgt 417361 tattgaccgc ggtacagcaa tcggagaaac atcatctaca aaacaagtcg tggaaaacga 417421 ttatgtgaaa aacgtaaacg cagtgaaaaa tggtcatgtc atctaccttg attctgctac 417481 ttggtattta tcaggaggcg gacttgagtc tatgacgcaa atgattaaag aagtgaaaga 417541 cggtttagaa aagtaaaacc aaaaagagcc tccgctaaat agcggggctc tttttttgtt 417601 aatcagcgtg ccggctgctg ttcggcaggg cgctgaggtt tctttaatgt gaatgagaga 417661 aggaagccga caagtgcaat gacggcagcc actataaaag cggcgttcat gccgtgcagg 417721 gcggcgtgct tcacatttgt cgtgcctgca tgtgccgcct ggttgctcat cacggaaacc 417781 aatagtgcgg ttccgatcga gccgccgact tggcgaatcg tgttgttcat cgcagttccg 417841 tgcggaatca agtggcgcgg cagcgcattg attccggctg ttgtcaccgg catcatgatc 417901 atggcggtgc ctaagagacg aacggtgtat aaaacgacaa tccaagcgag tgacgtatgg 417961 tcagtcagct gcataaacgg cagagatgtc aggaagatga tgcagaaacc ggcaatcgcc 418021 agccctcttc cgccgacacg gtcaaaaatt ctgccgataa tcggcgacat aaagcccatc 418081 acaacggctc ccggcaggag cataagccct gtatcaaaag ctgtgacgtc tctgacattt 418141 tgtgtataaa gcggcaggat ggtttccgta ccgatcaata atgcaaagac gagggttccc 418201 agcagtgttg ttaagctgaa aacgccaaac gtgaagacgc ggaattccag catcggtttt 418261 ttaagcttca tttgtcttgt gataaacaag agcagcgcga tgacacccac cagcagtgaa 418321 atcaagacgg ttgaactgga ccagccataa gagccgacgc ttgagaagcc gtacagaagg 418381 ccgccgaacc caaatgttga aaggatgact gataaaatat caatctgtgt ttttcttaaa 418441 gtcgtcacgt ttttcatcag gatgctggca agaatcaaat caatcacagc aaacggaaga 418501 ataatataaa acaatgatct ccaagagaaa gcttcgacag cccatccgga aagagtcggt 418561 ccgatcgcag gcgcgaatga gatgaccaat ccgaccatac ccatagcctg gccgcgcttt 418621 tcaatcggaa agattgtcag gaatacagtc tgcatgagcg gcatcataat gccggctcca 418681 gccgcttgaa tgatacgcgc tgtcagcaga accgggaagt tcggcgcgaa cgctccgacg 418741 actgttccgg cagtgaaaat gctcattgct gtgatgagca gcgcccggct tgtgaatttc 418801 tcaattaaaa acgcggtaat cggaattaaa atcccgttgg ttaacataaa tgatgttgtc 418861 agccattgtg cttggttggc atcgacattg aaatccctca tgatatgggg aagtgcagta 418921 atcaacaatg tctggttcaa aatcgccaca aacgctccgg ctaacaaaat gccgacaatg 418981 acagaacggt taaaaggttt ttgttcaata cttgtgttca atacatatcc cttcttttct 419041 ctaagtaatt aacagtgttt ttaacatgga aacgggctgt gttaaaacac cggtttgttc 419101 cagatagcca atcagtgatt tgagtaaaaa agcgcggggt tcttccttct tcgcttcttc 419161 ctccagcata gcggctgcgg atgtcagttc atctacgtca tagtccgcgg cggacaggga 419221 agagatgcct ttatgtaatt ccttcaggct ttccgataat aggactgatt tatcctttgg 419281 cttgtaggag gatgctgaat gaatataaag ctcgatggct tcgggcggaa gaagagactg 419341 gcgggtttcc ctgtttttga taatctgatt gagggtgctg atgataaact ctgcgatcgg 419401 gtcaagctca agcggttttt cctcgatttt gatcagcatt aaaaactcac gcatcatgcc 419461 gtgaagaatg ataaccaaat cccacacaaa cgggagaatg gtttctccat acgcctggat 419521 cagcgaatcg cggtgccagc agataatcgt cgatctggtc tgatggatat gctgtttgac 419581 ccggtcattg tgcagcttgg ggtttccgta ggtcagcata ttgaaaaact gctgattccg 419641 cctgaagccc tccagttcca ttttgacctt ttgcgtcaaa cgctcctccg gtgtaagtgc 419701 tgtattttcc tgaagtcttg aggccgcggc caccatttgc ttctggttaa atgacagcag 419761 ctccaaaagc agatcttctt tagattggaa cagcttatat atcgaagctt ttgacatctt 419821 acattcttct gcgatcgcct gcatggaaac cgacgtaaaa tccttttccg aaaaaagctt 419881 tcgcgcggct aacaagatat ctgttttttt atcaagcatc tcatggcttc cttctttctt 419941 gaacattaga aaacccattg gttcacagaa aaccaatgag taacaatgaa aaaattttac 420001 cagataaaca aaatagaagt caatggattt taaccgggta aatgaaaggc ctgccggaaa 420061 atccgacagg ccgaataaga gcttattttt caactttaaa tccttgtttt tcaagcattt 420121 cacggatgtg cggatagtac aggcgctcat agtaggaagc gatgctctgt gaccagtttc 420181 ttgtttcttt tccgtttgtc cgtttattca tgtattcaga catctgttcg tcgtatgcct 420241 gaatgtgaga cgtcagctca tcctgattca aataagtttc ctgatgattg acagcttcct 420301 gcggcaagcg cggttttttc gctgaacggt cggcaggatg cccaatgaca aggccggata 420361 aagggaacac gtatttcgga agctcaagca gttcgatcag ctcttgaggg tttccgcgaa 420421 ctgcaccgat cggaactgtg ccaagtccga gtgactcagc cgctgctgtt gctgtgccga 420481 gggcaatacc agcgtctact gcgccgacaa gaacagattc caatccattt gtgatttcca 420541 ttttgaaatc atgcagatct tcaagcgcaa ttttggcccg gttaaaatct gcgcagaaca 420601 gcaggaaaac aggagcttga tcgatccatg gctggccgcc tgccagctcg gagattttct 420661 ttttgcgctc tttatcctgg actgtgatca cagtcacttg ctgtccgttg atagaagaag 420721 gggctgattg caccgcttca atgatttggt ccaattgctc ctgagctaca ggctcatctg 420781 tgtagctgcg aatcgagcgg tggtctgtta aagatttaat cacttcattc atatgagaca 420841 cccttccttt actcgctaag ctctgtgcgg acaacatcaa gaggagcgct cagcagttct 420901 tttccttttg cgacaaaccc ttggaaatgc gcagtttcgt tatggaattt cattgccgct 420961 tcatctttcc atttttcaag catgacaaat gtattttctt cgcctacttt ttcgaatagg 421021 tcgtattgcg cgttgccttc ctcagctctt gaatgctgaa caagtgattg agcctcgctc 421081 aaaaattcct cgcgtttttc tggttttact ttgatgtaag cttgtaatac gatcatgtaa 421141 atctcctccg tcgttatgcg aatttattgt tcgaatttca tcgaactaaa tgtaacatgt 421201 attctaaatg aggtaaagga aaaaccctta tatagtaaaa ttgtcattct aattgttgta 421261 tgatacattt gtgtcatgaa cattccaaac catccagaaa cagaaacatt gcagctgaca 421321 aaggttcttc atgcacttag tgatccgctt cgtttagagc tcgtcaagca attagctgaa 421381 gcaaaagaaa aaacgtgcag cacctgtgca gatgtgcagg ttgccaaatc gactttgtcg 421441 catcatttta aagttttgag agaatcaggc atcgctcaag ttcggataga aggaaagcgc 421501 cggtattatt cgcttcgcgc tgaagacctt gaaaaggcat ttccgggact gcttgaagcc 421561 gtgctgaatg tagaccagga ccgctggtga atcaatcccc tgtaacgggg atttttttat 421621 gtccgtaaac cgctttgaaa agccgctgca caccctcctg aatatcttct tccttcagcc 421681 gtgcaaagcc gataatgaga gcaggcctgc ccgtttgccg cttgttttcc ttcaagttaa 421741 atcggctcat tccgaatatt tcaagctgca gcccggcagc atgtgacagg atgtcttgtt 421801 cggtgcgcct ggtatcaaat tcggtaacaa aatgcagccc cgcatttgcc ccttttacgg 421861 taacctctcc gctgaactct gcttctaaag cggtgatcag gcgttctctc ttttctttat 421921 aatgctgctt catttttttt atatgcttct gatattcacc agactcgata aattcctgca 421981 gggtgagctg tgtgagtgat gagcaagtct gcagatcata gccccgctgt ttgtatgccc 422041 tcaacagctc aggcggcaac accatatagc tgatccgtaa gccggggaga agggactttg 422101 aaaaggttcc catatagatg acattttgaa aacggtcgag gctttgcagc gccggaatac 422161 tgtctacatc atatgtgaat tcactatcat aatcgtcctc aatgatatat cggcgcggct 422221 cctcggctgc ccagttcagc agctgaattc ttctggatac aggcataatc gttccggacg 422281 gaaactgatg cgacggggtg gtcaccagca catctggctg ctgtctggtg atttcagcaa 422341 tcgacatgcc tttttcatcc agcatgatcg tctttacttg ttttccggca ttcttcaaaa 422401 gctgatacat gcgcctgtag ccaggctcct ccatcgcata cacggcttcc ttgggtaaaa 422461 gctcagtcaa cagctgcatg agcacctgtg tgcctgcccc tatgatcatt tgttccggcc 422521 tgcattttac acccctcgtc agggaaatga gcctcgtaat ggccgctctc acttcatata 422581 tcccttgcgg atgtgacata tcgccgagcg tgcggtatga gcgggaggcc gctttttgct 422641 cgcagcggaa ccagcttttg atcggaaaat ggtctgtatc ggaactcatg tgtgaaaacg 422701 atatccaatc gctctggtcg atgtgaatct cttttaggtc atccggcagt gcaaatggag 422761 ggtgctcctc ggcggaaaac atgtctagtt cctccacgaa gaaacccttt cgttcaatgg 422821 cgtacaaata cccctcagcc agcagctgct gataggctga attcactgaa tttacgctga 422881 ccttgagatt ttcagccagc tcccgcttgg agggaacctt cgagtgcggc agcagattgc 422941 ggctgaggat ttcttttttc agcttttgat aaatttgctg atagatataa tcggcttgtt 423001 ctgaacgatc gagtgtaatc gtgatatcca ttttgtagtt tctccttctg ataccatcaa 423061 aaagttataa ttggtacttt tcatcatacc aaagagaagt cagaatgata agaaaatacc 423121 gacaggggga tattcacatg agtcaaacaa cagcaagcat cacaactgca caatggcagc 423181 aaaaacggga tcaatttgtg tcaaaaggtg tgagcaacgg caaccgcagt ctggcggtca 423241 aaggagaagg ggccgagctg tacgatctgg atggccggag atttattgat tttgcaggcg 423301 ccatcggcac gttaaatgtc ggacactcgc atccgaaggt ggttgaggct gtgaagcggc 423361 aggcggagga gctgattcat cctggtttta atgtcatgat gtacccgact tatatcgaat 423421 tagcagaaaa actgtgcggc atcgcgccgg gcagccatga gaaaaaagcg atttttctta 423481 actcaggggc agaagcggtc gaaaacgctg tgaaaatcgc cagaaagtat acaaagcgcc 423541 aaggcgttgt ctcgtttaca cgcgggtttc acgggcgcac gaatatgacg atgagcatga 423601 caagcaaggt aaaaccttat aaattcggtt tcgggccttt tgcgccagag gtttatcaag 423661 cgccgttccc ttattattat cagaagccgg ccggcatgag tgatgaaagc tatgacgata 423721 tggtcattca agcattcaat gatttcttta tcgcttcagt ggcgcctgaa acggtggcgt 423781 gtgtcgtgat ggagccagtg cagggagaag gcggatttat tattccttcg aaacggttcg 423841 tacagcacgt cgcttcattc tgcaaagaac acggcattgt ttttgttgct gatgaaatcc 423901 aaaccggctt tgccagaact ggcacttatt tcgcaattga gcactttgat gtagtgcccg 423961 atctgatcac ggtttctaaa tcgcttgcgg caggcctgcc attaagcggt gtgatcgggc 424021 gtgcggaaat gcttgatgcg gcagcgccag gggagctggg cggcacgtat gccggcagcc 424081 cgctcggctg cgcggcggct ttggcagtct tggatattat cgaagaagaa ggactgaatg 424141 agcgatctga agaaattggc aaaatcattg aagacaaggc gtatgagtgg aaacaagaat 424201 tcccgttcat cggtgacatc cgcagactcg gggcgatggc cgcaatcgaa atcgtcaagg 424261 atcctgacac gcgtgagcct gataagacaa aagcagcagc gatcgcggcc tatgcgaatc 424321 aaaacggatt acttttgctg acagcgggaa ttaacggtaa tatcatccgc tttttgacac 424381 cgctcgtcat ctcagacagc ctattaaatg aagggctcag catcttggag gcgggcctgc 424441 gagcttaatc attggaaaga aaatggccgg gtctgctatc attttaagta atcatgaaaa 424501 gaaaggaatg ttcaatatgc cagatcaatt aacggtctac aacccggcta cgggcgagga 424561 gatcaaaacg attcctcagc aatcagccac agaggtagaa gaagccattg aacgttcaca 424621 tcaagcgttt aaaacgtggt ctaaaacatc agcgaacgaa agaacgtctc ttttgaaaaa 424681 atggtatgag ctgattgttg aacataaaga agagcttgca gatttaatta caaaggaaaa 424741 cggaaaacca taccaggaag cagtcggcga ggtactttac ggcgcaggct atatcgaatg 424801 gttcgcagag gaagcgaagc gtgtgtacgg aagaacggtc ccggccccga caactggtaa 424861 acgaattgtt gtcacacgcc agccggtcgg ccccgttgct gctatcacgc cctggaattt 424921 cccgaatgcg atgattacac gcaaagcggc gcctgctctt gccgccggct gtacatttat 424981 catcaagccg gcgccggaca caccgctgtc tgcttatgaa ctagcgcgcc tcgcatatga 425041 agcgggcatt ccgaaggatg ttcttcaggt tgtgatcggc gatggagaag aaatcggaaa 425101 tgtgttcaca agcagtccga aaatccgcaa aatcacgttc acaggctcaa cacctgtagg 425161 gaaaatcctt atgaaaaaca gcgctgacac cgtaaagcac gtctcaatgg agctcggcgg 425221 acacgccccg ctgatcgtag atgaagatgc ggacattgac cttgccgttg aacaggcgat 425281 ggcgtccaaa taccgaaacg ccggccaaac ctgcgtatgt gccaaccgcc tgatcgttca 425341 tgaatccatt aaagatgaat ttgctgcgaa actgagcgag caagtgtcta agctgaaagt 425401 cggaaatgga cttgaggaag gcgtcaatgt cggcccgatt atcaacaaac gaggcttcga 425461 aaaaatcgtc agccaaatag atgatgcggt tgaaaaaggc gcgaaagtga ttgctggggg 425521 cacatatgac cgaaacgatg acaaagggtg ctactttgtg aatccgacag tgctcaccga 425581 tgtcgatacg tccatgaaca tcatgcatga ggaaacattc ggcccggtcg ccccgatcgt 425641 cacgttttct gatattgatg aagcgattca gcttgccaac gatacaccgt atggcttggc 425701 tgcttacttc ttcacagaaa actaccgccg cggcatctat atttccgaga atctagagta 425761 tggcattatc ggctggaatg acggcggacc gtcagcggtt caagcgccat tcggcggaat 425821 gaaagaaagc ggcatcggcc gtgaaggcgg ttcagaaggt atcgagccgt accttgaaac 425881 aaaatatttg tccatcggtt tataaaagaa tgcacgctcc tgagagctgc cggattttcc 425941 ggcagctctt tttgtgttcc ggcgaataat cacaacaatt ccagccaaaa taacagcaaa 426001 tacattttga aagaaggttc cccaacaatg gatttattat tggctcttct cccggctttg 426061 ttttggggga gcattgttct cttcaatgtg aaattaggcg gcgggccgta cagccagaca 426121 ctgggaacga cgatcggggc actcattgtt tctatcgtta tttacttttt tgttcagccc 426181 gttctgtccc ttcgcatttt tattgttgga atcgtatccg gcttattttg gtcacttgga 426241 caggccaacc agttgaaaag cattcaattg atgggcgtgt cgaaaacaat gccgatttcc 426301 acaggaatgc agctcgtttc cacctcgctg ttcggtgtga tcgtgttccg cgaatggtca 426361 acaccgattg cgattacgct tggcgttctc gctttgatct ttatcattgt gggaatcatt 426421 ctcacgtcct tggaagataa gaatgataaa aaagagggcg agccaagcaa tttgaaaaag 426481 ggcattttga ttctccttgt ttcgactctt ggttatttgg tttatgtagt cgtggctaga 426541 ttattcaatg tgtccggctg gtccgcgctg ctgccacagg caattggcat ggtggtcggg 426601 gggttagttt taacctatag acacaaaccc tttaacaagt atgcgatcag aaatattctc 426661 ccagggttaa tctgggcagg cggaaatatg tttttgttta tttctcagcc gcgagtcggc 426721 gttgcaacga gcttttccct ttcacaaatg ggaattgtca tttctacgct cggcggtatt 426781 ttcatcctgc gtgaaaagaa aacgaaacgc cagctaatag caattgcgat cgggattatc 426841 ctgattattg ccgccgccgt attcttagga atcgccaaaa caaattcata acaaatggag 426901 gaggatgtat atgtatccgg atttaaaagg aaaagtcgtc gctattacag gagctgcttc 426961 agggctcgga aaggcgatgg ccattcgctt cggcaaggag caggcaaaag tggttatcaa 427021 ctattatagt aataaacaag atccgaacga ggtaaaagaa gaggtcatca aggcgggcgg 427081 tgaagctgtt gtcgtccaag gagatgtcac gaaagaggaa gatgtaaaaa atatcgtgca 427141 aacggcaatt aaggagttcg gcacactcga tattatgatt aataatgccg gtcttgaaaa 427201 tcctgtgcca tctcacgaaa tgccgctcaa ggattgggat aaagtcatcg gcacgaactt 427261 aacgggtgcc tttttaggaa gccgtgaagc gattaaatat ttcgtagaaa acgatatcaa 427321 gggaaatgtc attaacatgt ccagtgtgca cgaagtgatt ccttggccgt tatttgtcca 427381 ctatgcggca agtaaaggcg ggataaagct gatgacagaa acattagcgt tggaatacgc 427441 gccgaagggc attcgcgtca ataatattgg gccaggtgcg atcaacacgc caatcaatgc 427501 tgaaaaattc gctgacccta aacagaaagc tgatgtagaa agcatgattc caatgggata 427561 tatcggcgaa ccggaggaga tcgccgcagt agcagcctgg cttgcttcga aggaagccag 427621 ctacgtcaca ggcatcacgt tattcgcgga cggcggtatg acacaatatc cttcattcca 427681 ggcaggccgc ggttaaacat aaaaagcgac ccagacatga catctggatc gctttcttta 427741 ttaggcacgc tttttcttta caagtgctgc tacagataaa ataatggcag ccgcagacag 427801 caccatcgct gtaatgtcta gagctgaaga acctgagttt tcggaatcgt cttctgtttt 427861 cgtggcgccg tgctcatctg tcacttgctt tgcagacgtg atgtttgtaa tggaatgagg 427921 tgtatcggca tcctcgtcac ctgtccactc aacaatgctg ccgtctttgt aatattggta 427981 tgcgtcccaa gcagcttcct ccgctttgtc agggtttttg gcaacaaagg taaactgctg 428041 gaactggcct tcctgaatgc ctccgtcagt cgcctcccat gtcacggata ctgatttgtc 428101 atcatgtttt tgagtggaaa ccttccagcc cggaattggc tcatattgct ggaattcaac 428161 atccttcggc attttgagga caaccttcgt tgtcggcaga tttttctcag aaggaacctt 428221 cattgtatac gtttcccaag agcctgcagc agactcagcc ggttttacag aaacatgcgc 428281 gctggcaggg gccgtaaaga ataagaggga gccgacaata gccggacata gtgtcaatgc 428341 gatttttttc aacaacgtaa acactcctta attggtcttt gtaaacatga tattgatttc 428401 gttaaagtcg ccggtcaggc cgtggacttt gatcttccag tttccttttt cattaatcga 428461 caggttttga tcttggaaga cgccttttgt tttttctttt aatgtaaagg tgcttttgtt 428521 ttcgctgcct gacaggcctg ttttataaac ggttaacgtg atttgctgga tgtttttcac 428581 gggatcaccg ttatggtcgg tgacccgcag ctcaaaaaca ttttttccag gctggtttgg 428641 gctgatgctg agagaaacgc tttgtccgtt ctctatcgct ttggtttggt agaacggttc 428701 cggcgctggc tcaggcgggc ttggcaggct tgtaaacacg gccgctgtga tcaatacagc 428761 gatgccgatt gcccactccg ctttcaacgt tcggctgatt cctgtgcggc gctgctttct 428821 ggtaagcaga aaatgaattg cgcctaagac cagcatgaaa acaaacagcc cgcttttcac 428881 taaaagagct tgtccgtacg ctgtatggaa cagtgaatcc attgaacgaa tgatgaaaaa 428941 tccattgagc aagcctgaaa acaaaatgac gccgactgca gtgagcgccc atggggagaa 429001 ccgtctgacc gtctcccacg cgagcgtttt gtcaggctgc ctccattctt ttgagagcag 429061 caaaacgagt gccgctattc cgccgaccca gatggaagcg gaagttaaat gaaggaaatc 429121 catcaaaatg ccgaccgttt tttcttcaac gacagcagca tgcccggtaa acgccttggc 429181 aagcaggaga ccgaaaaaga aaatgagcgg cgctgtccaa tagccaaagg atgaaaagcg 429241 gtttttccgt atcgcaggga tgacagacag tgcgagcagc acgaacagcg cagcctgtat 429301 gatccaaatg gagccgcctg ctgtctcaaa cagtgtttct ctgatgtagc ccggctggaa 429361 tgcgctgccc cagccgccgc ctgcgttcgc ttttgtctga atcggaagct gaagcaaaag 429421 cgccagcccc aatgctgcga tcgagccggt caggatacgt ctcgtccgtt tgacgagctg 429481 ttctgatttc cctttatacc agaaaagatg gaagaaaacc gttccgataa acagagataa 429541 ggctgtatac agaatcgcgc gatctgctgc tgttcccgga ttcagcgctg aatcggctgc 429601 tttttggctg ctgaatccgc catccgcttt cccgatactg aacggaatga cgccggaaac 429661 aggatgtcca tccgcggata cggcattcca ttccgctctg tacacatctt taggcagatt 429721 cttcttcagc ttcactgtca tgatgtgatg attatctttt ttgatttcag tcttgtccgt 429781 atccacacgg tcgccgtttg aattatagac tttaatgtaa tgaaaccctt cttcaaccgg 429841 ttcattaaat tcgatttcca cctgcgcagg ggcgcttttt aattcgctgt tttccccagg 429901 tgaagatttg acaatatagg cgtgagcaaa gcttgttttc ggcaggaaaa caagaaaaag 429961 cagaaggatg atccaccatc tgtttcgctt catcactcag acaccacctt ccgctgtatg 430021 tgttgtgtta tttcttggtg caggtgcagc gtttctttcg gtcttgaagc atgtcttcca 430081 gcgcttggtc gaaagtgcag acggctccgc cgaatccttt ttgaaatcgt tcggcatggt 430141 caagtgtcgc aaacggaatg gcctgcggct ggcagcagtg caggtttaat tcagcattta 430201 cgacgaaata agccgaaccg gcactgacgg ttgtctgtaa cagaaaatct ctgcaaatca 430261 agtgtgaaac ctcttccgtt ttatccgcgt aacgcaaaaa cgcgcaatgt gcgcagcata 430321 gctgttcaat gtcttggttt accgtaatca gctgaaccga atgagcttga ttgacgggct 430381 tcaagcaata gctgcacata tgatctgttt gaggtgttcg gacggggagc gtgatgccgc 430441 cggccgtttt aatgacctga tttgactgaa ccagctgatt gacatctcta tataccgtca 430501 tttccgaaac gccgaacctt gcgctgatgt cagaaattct aagcgagcct tcttctttca 430561 gccacttcag tatgtgttgc tgtctattaa tcggaagcat tcatacaccc tcttcattaa 430621 gatctattta agcgtagagg attttagaga cggagacaag taagtggatg ataaaaaatg 430681 tgaaaatgtg ttgaacagca acaaaacgaa acagaaggga ctctggtata atagacagat 430741 ggaatagaaa gtgaggaata ccctatgaaa gaaacaccat gcccgaactg cggcaaacct 430801 ttgacaggcg atatggtcag atcatcaaat gtgccttgtc aatttcgctg cggccactgc 430861 cgggaacggc tttatgaata taaagtttca gctccgatta tgctggtatc attagcggcc 430921 atcgtgctgc ttatttatct tttgatgctc ctccgcaatg cggcaggctc agtgctgcca 430981 gctgtacagc acgtgccgat ggctgtattt gcgcttgtgt gcgcgtatcc cgtttttatt 431041 gtgagtgagc ggatgattgc aaagtacgtg attcaaaatg gcaacatcat ttatagagga 431101 aagagaaaag gctcctgaaa ccaggagcct ttttattttt aaaaaattgt cacagtcatg 431161 tgccaaagtc ctctttactt tcaattgtat agggactgta agcgttttaa catagagtca 431221 aagggaagca tcattctctg aacatatttt tgtatcttac agcgacaaac aaaacaggga 431281 gggtttatat atgcagcagc aagaacagca gcaaggcggc atgaaagtga aagtgcaacg 431341 ctttgggagt tatttgagcg gaatgatcat gccgaatatc ggcgcgttta tcgcgtgggg 431401 tatcattacc gcgctgttta ttccggcagg atggtttccg aatgaacagc tgaacacgct 431461 ggtcagcccg atgattacgt atttattgcc gcttttgata gcgtatacag gcggaaaaat 431521 gatctacgac caccgcggcg gagttgtcgg agcgacagcg gcaattgggg tgattgtagg 431581 atcggatatt ccaatgtttt taggcgcaat gattatgggt ccgcttggcg gatacctcat 431641 taaacagact gataaattat tcaaggataa agtcaagcaa ggctttgaaa tgctgatcaa 431701 caactttacg gcagggattg tcggcgcggc tttaacgatt ctcgcgtttt acgccatcgg 431761 cccggttgtc ttgacgctaa ataaattgct ggcggctggt gtggaagtca ttgtacacgc 431821 taatttactg ccggtagcca gtgtttttgt agaaccggcg aaagtgttgt tccttaacaa 431881 cgccataaac catggaatct taagcccgat cggaatcgag caagcatctc aaacaggaaa 431941 atcaattctg tttttagtag aagcaaaccc tggaccgggg ctcggcattt tgctggccta 432001 catgttcttt ggcaaaggat cttcaaaatc aacggctccc ggtgcggcga tcatccattt 432061 cttcggaggg attcacgaga tttacttccc gtacattctg atgaaaccgg ccctgattct 432121 cgcagccatt gccggcggag caagcggact cttaacattt acgatcttta atgccggact 432181 tgtcgcggca gcgtcaccgg gaagcattat cgcattgatg gcaatgacgc caagaggagg 432241 ctatttcggc gtattggcgg gtgtattggt cgctgcagct gtatcgttca tcgtttcagc 432301 agtgatcctg aaatcctcta aagctagtga agaagacctg gctgccgcaa cagaaaaaat 432361 gcagtccatg aaggggaaga aaagccaagc agcagctgct ttagaggcgg aacaagccaa 432421 agcagaagaa gcgtctgagc tgtctcctga aagcgtgaac aaaattatct ttgcgtgtga 432481 tgcgggaatg ggatcaagtg ccatgggggc atccatctta agaaacaaag tgaaaaaagc 432541 ggagcttgac atcagtgtga ccaacacggc cattaacaat ctgccaagcg atgcggatat 432601 tgtcatcacc cacaaagatt taacagaccg cgcgaaagca aagctgccga acgcgacgca 432661 catatcagtg gataacttct taaacagccc gaaatacgac gagctgattg aaaagctgaa 432721 aaagtaatct tatagaaaga gagtgattgt catgcaagta ctcgcaaagg aaaacattaa 432781 actcaatcaa acggtatcat caaaagaaga ggctatcaaa ttggcaggcc agacgctgat 432841 tgacaacggc tacgtgacag aggattacat tagcaaaatg tttgaacgtg aagaaacgtc 432901 ttctacgttt atggggaatt tcattgccat tccacacggc acagaagaag cgaaaagcga 432961 ggtgcttcac tcaggaattt caatcataca gattccagag ggcgttgagt acggagaagg 433021 caacacggca aaagtggtat tcggcattgc gggtaaaaat aatgagcatt tagacatttt 433081 gtctaacatc gccattatct gttcagaaga agaaaacatt gaacgcctga tctccgctaa 433141 aagcgaagaa gatttgatcg ccattttcaa cgaggtgaac tgacatgatc gccttacatt 433201 tcggtgcggg aaatatcggg agaggattta tcggcgcgct gcttcaccac tccggctatg 433261 atgtggtgtt tgcggatgtg aacgaaacga tggtcagcct cctcaatgaa aaaaaagaat 433321 acacagtgga actggcggaa gagggacgtt catcggagat cattggcccg gtgagcgcta 433381 ttaacagcgg cagtcagacc gaggagctgt accggctgat gaatgaggcg gcgctcatca 433441 caacagctgt cggcccgaat gtgctgaagc tgattgcccc gtctatcgca gaaggtttaa 433501 gacgaagaaa tactgcaaac acactgaata tcattgcctg cgaaaatatg attggcggaa 433561 gcagcttctt aaagaaagaa atatacagcc atttaacgga agcagagcag aaatccgtca 433621 gtgaaacggt aggttttccg aattctgccg ttgaccggat cgtcccgatt cagcatcatg 433681 aagacccgct gaaagtatcg gttgaaccat ttttcgaatg ggtcattgat gaatcaggct 433741 ttaaagggaa aacaccagtc ataaacggcg cactgtttgt tgatgattta acgccgtaca 433801 tcgaacggaa gctgtttacg gtcaataccg gacacgcggt cacagcgtat gtcggctatc 433861 agcgcggact caaaacggtc aaagaagcaa ttgatcatcc ggaaatccgc cgtgttgttc 433921 attcggcgct gcttgaaact ggtgactatc tcgtcaaatc gtatggcttt aagcaaactg 433981 aacacgaaca atatatcaaa aaaatcatcg gtcgctttga aaatcctttc atttcggacg 434041 atgtgacccg cgtagcgagg tcacctctca gaaaactggg agaaaatgat agacttgtag 434101 gcccggcaaa gaaaataaaa gaaccgaatg cactggctga aggaattgcc gcagcactgc 434161 gcttcgattt caccggtgac cctgaagcgg ttgaactgca agcgctgatc gaagaaaaag 434221 gatacagcgg cgtacttcaa gaggtgtgcg gcattcagtc ccatgaaccg ttgcacgcca 434281 tcattttaaa gaaacttaat caataaccga ccacccgtga cacaatgtca cgggcttttt 434341 ttactatctc gcaatctagt ataatagaaa gcgcttacga taacagggga aggagaatga 434401 cgatgaaaca atttgagatt gcggcaatac cgggagacgg agtaggaaaa gaggttgtag 434461 cggctgctga gaaagtgctt catacagcgg ctgaggtaca cggaggtttg tcattctcat 434521 tcacagcttt tccatggagc tgtgattatt acttggagca cggcaaaatg atgcccgaag 434581 atggaataca tacgcttact caatttgaag cagttttttt gggagctgtc ggaaatccga 434641 agctggttcc cgatcatata tcgttatggg ggctgctgct gaaaatccgg agggagcttg 434701 agctttccat taatatgaga cccgccaaac aaatggcagg cattacgtcg ccgcttctgc 434761 atccaaatga ttttgacttc gtggtgattc gcgagaacag tgaaggtgaa tacagtgaag 434821 ttggcgggcg cattcacaga ggcgatgatg aaatcgccat ccagaatgcc gtgtttacga 434881 gaaaagcgac agaacgtgtc atgcgctttg ccttcgaatt ggcgaaaaaa cggcgcagcc 434941 atgtgacaag cgccacaaag tctaacggca tttatcacgc gatgccgttt tgggatgaag 435001 tctttcagca gacagccgct gattatagcg gaatcgaaac atcatctcag catattgatg 435061 cgctggccgc tttttttgtg acgcgtccgg aaacgtttga tgtcattgtg gcgagcaact 435121 tgttcggtga tattttaacc gacatcagct caagcctgat gggaagcatc ggcattgcgc 435181 cttctgcgaa catcaatcca tccggcaaat atccgtccat gtttgaaccg gttcacggct 435241 cagctcctga cattgccgga cagggccttg ccaatccgat cggccagatt tggacagcga 435301 agctgatgct cgaccacttc ggagaggaag aattgggggc gaaaattctg gatgtaatgg 435361 agcaagtgac tgccgacggc atcaaaacac gcgacattgg gggacaaagc acaacggctg 435421 aggtcactga tgaaatctgt tcgcgcttaa gaaagctctg atgaatcagg ccggtggcag 435481 atggctgccc cggcctgtcc atttccttac gaaaatttcc acgaaagtct aaccaagcag 435541 atccaaatgc tgtataataa tttggaattc ttaggaaagc atcgggtgaa ggaagttgaa 435601 tgcaaaaaca atcacgttaa agaaaaaaag aaaaatcaaa acgatcgttg tactcagtat 435661 cattatgatc gcagctctca tttttacgat cagattggtg ttttacaagc cttttcttat 435721 tgaaggatca tcaatggccc caacgcttaa agactcagaa agaattctgg ttgataaagc 435781 agtcaaatgg actggcgggt ttcacagagg agacatcata gtcattcatg acaaaaagag 435841 cggccgctca tttgtcaaac gtttaatcgg tttgcctggt gacagcatta aaatgaaaaa 435901 tgatcagcta tacataaatg ataaaaaggt ggaagaacca tacttaaagg aatataaaca 435961 ggaggtcaaa gagtcgggtg taaccttaac aggtgacttc gaagttgagg ttccttccgg 436021 taaatatttt gtgatgggag ataaccgtct caattcactg gatagcagaa acggaatggg 436081 catgccttct gaggacgata tcatcggtac tgaatctctc gtcttttatc cattcggtga 436141 gatgagacag gcaaaataaa atgcaatgca aaaagaacat ggaacatgac ggcaccgata 436201 ataaagcgcc gtgcacgttt aaaaaaatga tgatgaaacg gtgcggagcc ggctttccgc 436261 cccgtttttt atgatagaaa gcgttttgaa gaaaagggcc ctgttgaaat aaacagaatc 436321 aggattggcg aagccgtgaa gcgcatcgaa ttggtaaatc tcaagatggg tatgctgttt 436381 ttcccgcagt tttttgataa gaagcgctac gtcaaacgac ggctcataat tagggaaaaa 436441 caataggacc gggcaggctg gcatgtgatg aagagagtcg cgtatccggg aaccgtaata 436501 acaaaccgat ccgctcacct caggcatact gctgcatttc catgcgatag tagcccccac 436561 gctgaatcca atcacaaaga tgtgccgtcc ggcgttttgc ctgatcacat tctggatgat 436621 ggtttctccc gttttcagcc tttcgtgttt tgtaaattgt tcgtatgccg ttttttcttc 436681 tttcagtgtg tagacttcat cctcgccgag caggttgggc gtcaacacat catatccagc 436741 cattttgatc agccggccca tctttttcat atggctgttt acaccatata tttcgtgtgc 436801 gagaatgaca agcggttttg ggaacataac ggcctccttt tgtgtttttt ccattatatc 436861 ctatcgtttc actttaggct gagatataat ggtcaaaaaa aggagatata aaatgaactc 436921 attatctttg cctcaccgct atccattttt gtttattgat ggcgtgacgg atagcgagcc 436981 cggcaaacat gcggcagctt ataagctgat tagtgagaac gactggttta tcactgatac 437041 gcaaacagaa atgccgtttt cacttgtgat tgaagcgctt gcgcaaaccg cggcttttac 437101 aggaattaca gatgagaaca gcttgggatt attgtcttcg gtgaagaaag cggaaaagct 437161 gggagaagct gtgcctggtg accggcttga tcttacgttt gaagtcacgc gcaatcggcg 437221 cgggtttgtg ttcggacatg ccaaggcatc agttggagag cagcctgttg ctgaagctga 437281 aatcggcatc tatattgaaa aatgaaaaaa acccttcaca acattttgtg aggggttcta 437341 ttttgtgtcg taatcccgtt cgctttgaga gttatctctt tgctggcgtt tgtgtttttc 437401 atcattcata ttttccttca gctcttcatt aggaatcgga tcggttaagt cgttgtgctc 437461 ggggttttca tttggtttgt tttgctgttt tttttctgtc atgtttgatc acctcaccgt 437521 ttgttttcct cttattcatt ctcctcaaac ataggaaatc gcttttttgt cccgctgggt 437581 ataatgtatt agaatagaga gaagcacaac aaaaagataa agagaggtac atatatgtct 437641 gttcaaagag aagatgtaga tatcaagctg atcgcaattg atatggatgg tacactgctg 437701 aacgacgagc agctgatctc ggatgaaaac cgcaaagcca ttcgtgaagc ggaggataaa 437761 ggtgtgtatg tggtgatcag cacgggccgg acgctgatga cgtgcaggga gctggcggaa 437821 tcgctaaagc tgtcatcctt tctaatcacg gcaaacggca gtgaaatttg ggattcgaat 437881 tttaatttgg tggaacggaa gctgcttcat acggaccata ttcaaatgat gtgggatttg 437941 cggaataagc acaacactaa tttctgggct tctacggtga ataaagtatg gagaggcgag 438001 tttccggaaa acattacgga tcatgaatgg ctcaaattcg gctttgacat cgaggatgac 438061 gatatccgaa acgaagtgct tgaggagctg agaaaaaaca aagagctcga aatcacaaat 438121 tcaagtccga caaacattga agtcaacgcg cttggcatca acaaagctgc agcccttgcc 438181 aaggttacgg aaaaactcgg ctttacaatg gagaatgtga tggcgatggg cgacagcctt 438241 aatgacattg cgatgatcaa agaagcgggt cttggcgtcg caatgggcaa tgcgcaagac 438301 atcgtaaaag aaacggctga ttatatcacg gatacaaata ttgaggatgg tgtcgctaaa 438361 gcgattcgcc attgggtact ataaaaaaag agagtcctaa gatggactct cttttttagt 438421 ttggcaggtt ttattctggg accatggtag gttttctgac aaaagtattt cacaaactga 438481 tatgattcac ttataatgaa ataaagttca aaaattcgga atagtcgttc cgaatttcgg 438541 gacaataaat gacataaagc atatcgtttg ctttggcagg agggattctg tgtttcagat 438601 tgatttaaac tgtgatttag gagaaagctt cggagcctac aagataggcc ttgaccaaga 438661 tattttagag tatgtgacat cagcgaatat cgcatgcgga tttcatgcag gagatcctag 438721 tgttatgcga aaaaccgtcg cgcttgcagc agaaagaggc gtgaaaatgg gtgcgcatcc 438781 gggcttgccg gatttactcg gttttgggcg ccgcaatatg gcgatttctc ctgaggaagc 438841 gtatgatctt gtcgtttatc aaattggcgc gctctctggc tttctaaaag cagagggact 438901 tcacatgcag cacgtcaagc cgcatggcgc tttatacaat atggcggcag tcgatcaaaa 438961 actgtcggat gctatcgcga aagctgtcta taaggttgat cccggcctga ttcttttcgg 439021 tcttgctgag agcgagcttg taaaagcggg agaacggatc ggacttcaga ccgcaaatga 439081 agtgttcgcc gacagaacat accaatcgga cggcacgctg acaccgcgct cccagccgga 439141 cgcactcatt gaaagtgatg atgccgccgt cacccaggtc atcaaaatgg tgaaagaagg 439201 ggcggtcaaa tctcagcaag gacatgatgt gtcattaaaa gcagatacag tctgcattca 439261 tggagatgga gcccatgcgc tgacatttgc gcaaaaaatc agaaaacagc tcaaagcggc 439321 tggaattgaa gtgacagcta tttcagaaca gaggtcaaca taaaggagga acaatagatg 439381 gagcagcaga aaaagacagc aggaaaaaaa gcgggcagct ggtcattgct gatgggcgcc 439441 gcctttttaa tggcgacatc agcaatcgga ccgggtttcc tcacccaaac cgcaacattc 439501 acaaacacac tcgcagcaag cttcggtttt gtcatcttaa tctctattat tttagatatt 439561 ttcgcccaaa ccaatgtgtg gcgcatcatc gcagtttctg gaaaacgagg tcaggaaatt 439621 gcgaatatgg tgcttcccgg actggggtat ttcatcgcca ttctcgtcgt gcttggcgga 439681 ctagctttta atattgggaa tatcggaggg gccgggctgg gacttcaggt gctgttcggc 439741 attacacctg aaacaggcgc tttaatcagt gccgttatcg ccattttgat ttttgtcatc 439801 aaggaagcag gaaaagcgat ggaccgtttt acgcaaatcg cggggttcgt gatgattatt 439861 ttaacggtct acgttgcggc gacgacagct cctccggtcg gacaggcagt cgcaaataca 439921 ttcgtcccgg aacacatcag catatttgcc attgtcaccc tagtgggcgg aaccgtcggc 439981 ggttatatca catttgccgg aggacaccgt ttgcttgatg ccggaattaa aggaaaggaa 440041 tccattccgc aggtgacaaa gagctcggtt gtcggcattt taattacatc tgtcatgcgt 440101 atcgctcttt ttcttgcggt tctaggcgtt gtatcgaaag gcctgcacat cgatgaaagc 440161 aacccggcgg cttctgtctt caagctggct gctggaaatg tcggttataa aattttcgga 440221 ttgatcatgt ggtctgcggc gattacgtct gttattggag cagcctatac atctgtttca 440281 ttttttaaaa ccttttctcc aaaaattgaa aagaattcac gcggtattat tatcggattt 440341 attgtggttt ctacgttagc ttttgtcaca atcggccagc ctgcgaagat cctcgtcctt 440401 gtcggttcac tgaacggctt aattctgccg attgcgctcg gaacgctgct tgttgccgcc 440461 tacaagaaaa acattgtcgg tgattataag catccgcttt ggctgacaag cacaggcgcg 440521 cttgtagtga ttgtaatggc agttatggga atctacacgt tatgtacaca acttcctcaa 440581 ttgtggagct gatataagtg gagcaattaa acaaaatggc gccaaaggat gtacgcgccc 440641 tgatacgaga ggggaaaata aacgggccga ccgcaggcat gtccggcggc tacgcccaag 440701 cgaatcttgt ggttttgaaa aaggaccttg cgtttgattt tctgctgttt tgccagcgaa 440761 atcaaaagcc ctgccccgtg ctggatgtga ctgaagcagg ttcgcctgtg ccgtctctgg 440821 ctgcgccgga tgctgatatc agaacggact ttccgaaata ccgtatttac aggcacggta 440881 tcctaacgga agaagtatct gatattacgc catactggga ggacgatttt gtcggctttc 440941 tgatcggatg cagtttctcc tttgaacagg cactgatcaa taatgggata gctgtccggc 441001 atattgatga ggggacaaac gtctcaatgt ataaaacgaa tatcgattgt gttccggcgg 441061 gggcgtttca cggacagatg gttgtcagca tgaggccggt tcctgaacgg ctggctgtac 441121 gtgctgcaca agtgacctcg cgttttccgg ctgtgcacgg agggccgatc catattggca 441181 atccgggagc aatcgggatt cgcgatctcg ggaaaccgga tttcggagat gccgtttcca 441241 ttcgtgacgg cgaggttcct gttttttggg catgcggagt gaccccgcaa gccgtggcta 441301 tgaatgtaaa gcctgaaatg gtcatcacac atgcgccggg gcatatgctc atcacagata 441361 ttcgagacga gtcgcttgcg gtgctgtagc ctctcgtcat cctgatgaac gagaattaaa 441421 agaggtgaga aagatgactg tacgatatca aatcgaacag ctcggtgatt ctgcaatgat 441481 gatccgattc ggagaagaaa tcaatgaaca ggtcaacggc attgtccatg cagcggccgc 441541 ttatatagaa gaacagccat ttccgggatt cattgaatgt atcccggctt ttacaagtct 441601 aaccgtattt tatgatatgt atgaagtgta caagcatttg cctcaaggca taagctcacc 441661 ttttgagagt gtcaagcgcg atgtcgaaga gcggctggca gaaatagccg aagactatga 441721 ggtcaaccgc cgtattgtag aaattcccgt ttgctatggc ggtgaattcg gtccggattt 441781 agaagaggtg gcgaagatca atcaactgtc accggaggaa gtaatcgaca ttcatacaaa 441841 cggtgaatat gtggtgtata tgcttggctt cgcgcccggt tttccttttc taggcgggat 441901 gtcaaaacgc attgcagctc cgagaaaatc atcgccaaga ccgtcgattc ccgcaggttc 441961 ggtcggtatt gcgggattgc agacaggcgt ttatccgatt tcaacgccgg gcggctggca 442021 gctgatcggc aaaacgccgc tggctctttt ccggccgcag gaaaacccgc cgacattgct 442081 gcgggcggga gatattgtga aattcgttcg catctcagaa aaagactatc acgcctataa 442141 ggaggagtcc aattgagcat gaaagtatta aagcccggac tgctcacaac ggttcaggat 442201 ataggcagaa cgggttacca aaaatacggc gttctggcca gcggcgctat ggacacggtt 442261 tcactgcgca ttgccaatct gttgatagga aacggcgaaa atgaagcagg tctcgaaata 442321 acgatgatgg ggcccggtcc gtcgtttcat ttttcaaaac agacactgat tgctgtgaca 442381 ggggcggact tcacgctgcg tattaatgac gaggaagcgc ctttatggaa gcctgtgctc 442441 atcaaggaaa acagcacggt cagctttggc ccctgcaaac tcggcagccg tgcttatttg 442501 gcggcagctg gcggcattga ggtgcctgcc gtcatggaaa gtaaaagcac atacgtcaga 442561 ggaagcattg gcggacttca tggcagagcg cttcaaaaag aagatgaact gaacattgga 442621 gagatgtcag ctctttcgca aaccatcctt tctcgcttaa gttcgcagct tggaaaacag 442681 ggatttgcag caccgaagtg gtcagtcagc cgcggcagat ttctgccatt gaagaagaat 442741 cccgtcattc gggtgctgga aggaaagcaa tttgcctttt tcacagaaga atcaaaaacg 442801 cgtttttatg aagaagcatt tcgtgtcacg ccgcagtccg accgtatggg ctacaggctc 442861 aaaggagaac cgctcgaact gaaggccccg cttgagatgg tgtcggaagc ggtttcattc 442921 ggaacagttc aggtgccgcc tgacggcaac ccgattatcc tgcttgcaga ccggcagacg 442981 actggcggct atccgaggat cgcgcacatc atatccgctg atcttccgat tgtttcccaa 443041 atcatgccgg gcgagcacgt tcagtttgag cctgtgtccc tccaggaggc agaagcgctt 443101 gcggtagaac gggaacagca tataaaagaa ctgaaaacga gaatgaagat ggaatggctg 443161 acatagcaaa ggggatgaat gatgcagaat aaaaataaaa ccgtagtcaa atctatggcg 443221 ctgcttaatt tgtttttgca taaaccaagc ctaaccttaa gtgaactggt gtcgctgacg 443281 ggaatgccga agacctctgt tcaccggatg gtcagctcct tggaggaaat ggggttcctc 443341 agtcgggatg cgtccggcgc ttattcgctg ggattggtgt ttttggaatt cggacagctt 443401 gtcgctgaca ggctggatat cagaaaaata gcgaaaccgg tgatggaaga gctgtgccgg 443461 gaagtggatg aggccgtgca gttgatcatg agggacggca atgaagcgat atacgttgag 443521 aaaatagaag ggacacagac tgtgcggctg tatacggcga tcggcaggcg ttccccccta 443581 tacgcgggag cgtgcgccag aagcattctg tcctttcttc cccgtgaaga aatcgaagca 443641 tacatcaaac aaaccgagct catttcgatt ggctccggaa cgattaccga tcccgaaaaa 443701 ctgcttcagg agattgatgc ctctgtgcaa aatggctata ctgtcagcta ttcagagctc 443761 gaaaactata cggcggcgat cggcgccccg atctttaacc atgagcgcca ggtggcagcc 443821 ggcattagca ttgcaggctt tgaagcgaga tttacagaag acaggctgcc ctatttaaca 443881 gaaaaggtga aggacgccgc tttacagatt tcaagaaaaa taggatatac ataagtagcc 443941 aatcttttct ctgctgcgta cattaacgta tcgacgttca agagtggagg aaagaacatg 444001 gtgcttcgat atacagctct gggcgattcc ttgacgacag ggagaggctc cgggctgttt 444061 tcacccggct tcgtccagcg ttttggggac atgatggaag ctgacttgaa aacaagaacg 444121 gcaataaaca tatttgccag atcaggtctg aatacagaag agattttggg actcctgtca 444181 tatccctatg tgcaaaaatg tattcgagat gctgatatga taacgatcac agggtgcgga 444241 aacgatctca tcgattcggt cttagcctac caaacctcta aggatgaaac gattttcagc 444301 cgtgtatccg cccattgcca tgagaatttt gaaaagatga ttgccaaagt cgccgagatt 444361 aaaggagaaa atccttcccc gtacgccatt cgtgtgttca acttatacaa tccgtttccc 444421 gaaattgata tcgccggcaa atggatcact tcgtttaatt cacatttaga aacacttgca 444481 tcagcacccc atgtcaaaat cgcggatgcc tatagcatct tcaaaggcaa agaacaggaa 444541 tatctgtcct ttgacggtgt ccatccgaac agcaaaggct atcaagcgat ggctgaagcc 444601 gttcacaagc taggctataa agaattatca gtttcataga aaacgcgcct catgacaggc 444661 gcgtttttta tgtgtgatcg aaatattaaa agaaacttaa aattctctgt cttctgttct 444721 acagacaaac aaagtgcgct agaataatgg agggcgtagg caaatatagc cataacgttc 444781 aatatttcgt atataaggaa ggatggtcct tttgtttcgg atttttaaaa tgtcttttgc 444841 ggttatcatt attatactgg cgcttattgc ttttaactat acggaacaca cctctgtaat 444901 ccaatcggtc atgctcgtct ttcttggtgc ggtcatgttt atgcaggggc ttgaagagcg 444961 caaaaaagaa aatgacggct caggcgcttt taatatttat accgccgttt ttgtatggtc 445021 tgtctccctt atcggtttta cacttcatat tatataaatc tattacacat cctgaaaatg 445081 ctcgaccgtc gggaacgggg tatagaaccg atgaagcaag gctttccact cttgatactc 445141 tgaagaaccg cgaaagcctt ccgtatggtc ctcaagtgtt tcccactcca caagaagcag 445201 atatttatgc gtttcctcca tgcattttga taacgagtga gtgatatagc ccttcatgcc 445261 ggaaataatc ggcgcagctt gccggaatgc atcctcaaac tcttgttcaa ggccttcttt 445321 aatgtgaagc attgctgcct ctctgaccat gctatccctt ctttctgtct tttcaaatag 445381 tctacagcaa acgataggag atttctgcaa aatcggtgaa cttttccttc attttcaaaa 445441 aaatcttgca cgcaccaatt caattaagag aaaataacaa gtggaaggca ggggaaagtc 445501 atgttaaaaa agtgtattct actagtattt ctatgcgtcg gattgattgg gttaatcgga 445561 tgctccaaaa cagattcacc agaggatcgc atggaagcat tcgtgaaaca gtggaacgat 445621 cagcaattcg atgacatgta tcaaagcctg actaaagatg tcaaaaaaga aatctccaaa 445681 aaagatttcg tcaacaggta taaagccatc tatgagcagg ccggcgtaaa aaatttgaaa 445741 gtcactgcgg gagaagtaga taaggacgat caagacaaca agacgatgaa acatatcccg 445801 tataaagtca gcatgaacac aaatgccggc aaagtcagct tcaagaatac tgctgtgctg 445861 aaattagaaa aaacagatga cgaggagtca tggaatatag attgggaccc atcgtttatt 445921 ttcaagcagc tggctgacga caaaaccgtg caaattatga gcattgaacc gaaacgaggc 445981 caaatttacg ataaaaatgg aaaaggctta gccgtcaata cagatgttcc ggaaattgga 446041 attgttcccg gagagcttgg cgataaaaaa gagaaagtca taaaagaact cgccaaaaaa 446101 cttgatttga ctgaagacga catcaagaaa aagctggatc aaggctgggt aaaagacgat 446161 tcgtttgtgc cgctcaaaaa ggtcaagcct gaccaggaga aattagtttc tgaagcgacg 446221 tcattacaag gcgtaacaag aacgaatgtc agctcccgct actatccgta tggcgaaaag 446281 acagcccatt tgacaggcta tgtccgcgcc attacagcgg aagaactgaa gaaaaagaaa 446341 gaaggaacgt acagcgatac gtctaacatc ggtatcgccg gacttgaaaa tgtgtatgaa 446401 gacaagctaa gaggcacaac tggctggaaa atctacgtgc cgcaaaccgg ggaagtcatc 446461 gctgaaaaga aagcaaagga cggcgaggat cttcacctca caattgatat caaaacgcaa 446521 atgaagctgt atgatgaact gaaggatgac agcggggcgg cagtcgcgct gcagccgaag 446581 acaggcgaaa cactcgccct tgtcagcgcg ccttcctacg atccaaacgg atttattttc 446641 ggctggagcg ataaggaatg gaaaaagcta aacaaagata aaaacaatcc gttttcagcg 446701 aaattcaata agacatacgc gccaggttct accattaaac cgattgcggc tgctattgga 446761 atcaaaaacg gcacccttaa agccgatgag aagaaaacaa tcaaaggcaa ggagtggcaa 446821 aaagattcaa gctggggcgg ctattcagtg acacgtgtgt ctgagagact tcaacaagtc 446881 gatttggaaa acgcccttat tacgtcagac aatatttatt ttgcccagaa tgcgcttgat 446941 atgggagcgg acacctttac aaaaggcttg aagacattcg gtttttcaga ggacgttccg 447001 tacgaattcc cgatccagaa atcgtctatt gcaaatgaca agcttgattc agacattttg 447061 cttgcggata caggctacgg acaagggcaa atgcaaatgt ctccgcttca cttggcaact 447121 gcttacacgc catttgttga caatggagac cttgtcaaac cgacgctgat caaaaaagat 447181 tcacaaacag ctgatgtttg gcacaagcaa gtggtcacga aggaaggagc ggcagacatt 447241 acaaaaggtc tgaaaggcgt tgtggaagat gagcgcggat cagcgtatca gcctgtcgtg 447301 aaaggaatca cagtggctgg aaaaacagga acagccgagc tgaaaacatc aaaagatgat 447361 aaagacggca cggaaaatgg ctggtttgtc ggctacgatt acgaaaacaa agacctgctt 447421 gtcgccatga tgatccaaaa tgtgcaggac cgcggcggca gccactatgt cgttgagaaa 447481 gcgaaaaagc aatttcaatc gaattaaaat gtctttttaa aaggagcgaa aggaaaaagg 447541 ggatctgagg ccgaatgaac tagtaagggg gcaaaacccg gtttatacaa agaaaagagg 447601 gattttgcat gcagcgtatt caattggcgg aggatcttca attttcaaga gtcatacacg 447661 ggctttggcg gctgaatgaa tggaactatt cagatgctga acttctaagc ctcattgaat 447721 ggtgtatcga tcacggcatc acgacctttg atcatgcgga tatttatgga ggctatacgt 447781 gcgaaaagct gtttggaaac gcccttgccc tttcgcctgg attaagagaa aacatagagt 447841 tggtcacaaa atgcggtatc gttcttgaat cgcctgaacg gcccgctcac agatcgcatc 447901 attataacac aagcaaatcg catattttgg catccgttga gcaatcgctt atgaacctta 447961 ggacggatta tatcgatatg cttttgattc acagaccgga cccgctcatg gatccggagg 448021 gggtagcaga ggcgtttcag gccttgaaat gctctggcaa ggtcaggtac tttggcgttt 448081 caaattttaa agatcaccag tatcggatgc tggaatcata tttgcctgag aagctcgtaa 448141 ccaaccagat tgagctttcc gcatacgaat tagaaaatat gctcgacggc actttgaacc 448201 tgtgccagga aaaacggatt ccgccgatgg cttggtcgcc tctggcaggc ggcaaagtat 448261 tcactgaaaa cacggataaa gaccgacgtg tccgtacggc gcttgaatcc gtccaagggg 448321 aaatcggcgc cgcttcattg gacgaggtga tgtacgcatg gctgtatacg catccggccg 448381 gcatcatgcc gattgtcgga agcggaaagc gcgagcggat ttccgccgcg ataaatgcgt 448441 tgtcatacaa gcttgaccag gatcaatggt tccgcatttt tacagccgta cagggttacg 448501 atattccata aaaagcatca gtttaccagc tgatgctttt tcaatattgt cacaccgctt 448561 agtgccaaat taccatttat aagtgattga ttctttcttg aaagcgtttt atattaaaag 448621 gaaacctctc tatatcctct actgcatctc cttgcgactt catccgcaca tcaagattgg 448681 ctaggaggtc ttttttatgt atatgactgc cagagaacaa aagctgttaa agcacttatt 448741 attacaaaac agatatataa ccgtaactga gcttgctgag ctgatgcaag tcagcacgag 448801 aaccattcac agggaactca aatcaattaa accgctgatg gaaaccgtgg ggcttacgtt 448861 agataaacag cccggtaaag ggttgaaagc agtgggaagt cccgagggta aacaaaagct 448921 gcttactgat ttatcatatg aacagcatga atacagcgcc gacgaacgga aactgctcat 448981 tctttgttcg ttattagagt ctcaggagcc cgtcaaactg tacacgcttg ctcatgatct 449041 ccaggtgacg aatgccacgg tcagctatga cttagatgag ctcgagaagt ggatttctcc 449101 ctttggactg acactgatcc gcaaaagagg ttttggcatc cagctcatag ggccggagaa 449161 tgcgaaacgg aaaattgtcg gcaacttgat tgtgaaccgt ctcgacatcc aaatgttttt 449221 ggaagcggtt gaattaaaca tcaaaggaaa aaccgattct tcagagaaaa tgttcggggt 449281 tgtcagcaaa ggtgagctgt taaaaatgga gcgcatctta tttcagctca aagaaaaaat 449341 cgctttttca ttgtccgaca gctcctatat agcgctcgtc gtccatctga cgtatgcgat 449401 cgaacgaatt aagcttgggg aaactatcac catggagcaa aatgagcttg aggaactgat 449461 gaatgcgaag gaatacagct ccgctcttga aatcgcgggc gagcttgaac gtgccttcgg 449521 cgtgacgatt ccagaggcgg aggtcggcta tattacaatc catcttcgaa gcgccaatcg 449581 aaaatacaaa acagaataca aagcgcagga aattgagctg gaaacagccc tgcaaacaaa 449641 gcggctcatt gcttttattt cagacaaaat cagaatggat ctgacgaaaa actactcttt 449701 atatgaaggc ttgattgccc atttggagcc ggccgtcagc cgcataaaag aaaatattga 449761 gatatacaat ccgatgaagg aacagatcaa gcgcgattat tttctgcttt atatggcgat 449821 cgaagaaggt gtcgaaaagt attttccggg catgtccttt tctgatgatg aaatcgcttt 449881 tatcgttctt cactttggct cggctcttga aatcaaaaaa gaagaagcaa aagtgaaagc 449941 gcttgtcgtc tgctcaagcg ggatcggctc ctcgaaaatg cttgcctcca gactgaaaaa 450001 agagctgccg gaaattgaat cgtttgatat gtcatctctg atcgagctaa aggggaagga 450061 tgttcaagcc tatgatatga ttgtgtccac tgtaccgatt ccttatgaaa acattgatta 450121 catcatggtc agcccactat taaatgagga agacgcaaac caggtcaagc agtatatcaa 450181 gcggaagatt ccccttattc ttaacaaaaa aagaagctcg aaggaagagg cgcagcaagc 450241 tgatgtacct gacatgctgg aggcggcgga aagcataggg cggtatatgg aagttatcca 450301 agatgttctg cgccatttta cgctagctca actcaaaaca aacccggacc atagcatgct 450361 tctgctagag ctttttcaac agctgaagaa ggatggcctg atccgtgatc cggaaaaagc 450421 cgcggtttgc ctggctgagc gggagaaaca agggggattg ggaatccccg gaacaaacat 450481 ggcgctttat catctcaaaa atgatgaaat cgtcctgcct tttttcaaaa tgtttgatct 450541 cagcaccccc tatgaagtgg atggcatgga cggaaatacc ctcaggatga cacgcattct 450601 cgtcatgatg gcgcctggct cattatctgc tgaaggctcg gagattttaa gcgcgatcag 450661 ctcggcaatt atcgagagcg gagaaagcat ggcggggttt caggaagaag gaggacaaga 450721 attgtatcag cggttaaacc gcatattttt cacatggatg aaagaaaaaa acatactgta 450781 aacctgcatg gcacacgtca aaaatttggc gtgtgttttt ctgtggatgg ggaacaaaat 450841 aagaaaatgt gggactattt tatcattcag tattggaata attccaaaat gaaatagttt 450901 tacaagttat cttttttggg ttaaaatggg tgaggtaagg aagaaaatct aacaaattat 450961 tgaagattca agagaatata ggagatgacg atatggaaac attacagcat ctgattctgc 451021 atgacatgcc gaatagcgaa gaaatagagg ctgtaaaaag cggagaccat acactgacat 451081 ataaaggtta ccgtaaacgg attaatcagc tggcgaatgc catgcttcaa aaaggaattc 451141 aaaagggcga ccgtgttgca ttgctttgca aaaacggcca tcccgcctca actgttatgt 451201 tcgccgcact tgaaataggt gctgttgtcg tacctgtcag ctggcagctg aaaccatatg 451261 aaatgacagg cattttaaaa gcaagtgaac caaaagcgat gttttacgga gcggagttta 451321 aagagatact ggatgaagtt cttcctgaat tgtcctcact gtgtgtaaca atggaaacag 451381 gaacagctta cgaaacatct gctgaatttg aagcgctgtt tgcaggtcct gatcatttgc 451441 cagagacgga aatggtttca cctgatgata cagcacttct gatgtttaca tctggaacaa 451501 cgggaaaccc gaaaagatgc atgattacac atggcggcat atacagatac gttaaaaaat 451561 ccaacagctc aatagcacgt atgaagggcc ttcgttttct cgcgtgccat ccgatttatc 451621 atacgagtgc gctcatttgc atcatgcttg gaacgtttgc agaaacaaca tttgtgttta 451681 caaaggatca agatcctgtt cacatgctga aggtcattga agaagagaag attcagaccg 451741 tgatggctct tcctgtgttc tacacgtatt tgcttgaggc gtgggaaaag caccaaactg 451801 acttatcttc gcttgttatt ttaatgacag gcggaacaaa agtgccgagc agcctaataa 451861 gccgctatct tgatattggc attccgcttg cgcatggcta tggaagtact gaggcttggg 451921 gcatcagcac atggacgcct gatatgggaa tggataaagc ggcatctgca ggaaaacctg 451981 tggcaggtgt taaagtcaaa gtggaagatc ctctgaccgg agaagaactt cctcaaggag 452041 aaatcggcga aatcgttgtt catactccat tcttatttaa aggctatgaa gacaatcctg 452101 aagcaacagc gaaagtgctg caaaatggat ggtttagaac cggagattca ggatatgtag 452161 atgaagatgg ctttattttc atcacgggac gctacaagga tgtcattatt tacggaggcg 452221 ataacgtcta tcctgatcag gttgaagaag ttatccagca gatcccggga atccttgaaa 452281 cggctgtggt cggtattcct gacccgcttt acggtgaaaa accgaaagct tttatcgtga 452341 aaaatggcgg ccagcgcatc acggaagagg atgtcatcgc attttgtaaa gaacgcctgt 452401 ccgcttacaa aatacctgaa gttgaatttg ttaacgaact gccgaaaaac aaccttggca 452461 aggtgaaaaa agacgtcctg cgcaatcagg ctgtacattc ataaaagaag aagcccgtcc 452521 actttatgtg gcgggcttct ttgcagttgc acagacggaa agctcaggct taatgttctt 452581 aaattgtata tcaatgtctt cgaagccggc tgctttaaag tcagcaatca tctgtcttcc 452641 aaatgatttg gttttctcag gactggcatc cgcttcccgc ggctgcatcg taatggctgc 452701 tttgccgcct ggctttaatg cccgataaat ctgttttatg ccttttgttt ggtcattcca 452761 aatggtgtag ttgttaacgg aaatcacttt atcataaaac gaggcgggga gaggaaatgt 452821 ctcgatgctt ccttgtatca ggcgtacgcc ctttggtttc actctgcggg cggccagctt 452881 cagcatggcc tctgatacat caatcccatg aagatgaaca tccttctcgc gtttcagcat 452941 ctgctgcatg cagtatcccg ggccaaaccc gacttctaaa atgctgtccc cgcgcgtgat 453001 acccagctga ttgattgtcc actgattcag tgtttgattt tcagcagcca tgatgtaccc 453061 ggcaatcatg ccgatgacgc cctttggcct gctgaatctt ctagaaagca tgttaatcat 453121 tcagcaacca accccctttt tgagttaatt tcctctcagc gttccatgtg aaacattttt 453181 ctgataaagc aatgcgaagg tgccaagcca tgtttatcca aagagtgtgt gaggtacaca 453241 acaaatagac atgaaaacaa aggaggagaa tcatcatggc aaattatcca aaagaactgc 453301 cggcacaaac tcaaagtcgc cagccgggaa ttgaaagcga aatgaatcca agtccggtgt 453361 atgagtacga ggattataaa ggagcagaca aattaaaagg aaaagtagct cttattacag 453421 gcggcgacag cgggatcgga cgcgcggttt ccgtcgctta cgcaaaggaa ggcgcagaca 453481 tcgccattgt gtataaggat gagcatgaag acgctgagga gacgaagaaa cgtgttgaac 453541 aagaaggcgt aaaatgcctg ctgattgctg gtgacgtagg tgaagaggaa ttctgcaatg 453601 aagcggttga aaaaacggtc aaggaactag gcggccttga catccttgtc aacaatgcag 453661 gtgaacagca cccgaaggaa agcatcaaag atattacgag cgaacagctt caccgcacat 453721 tcaaaacaaa tttttattct caattttatt tgactaaaaa agcaattgat tacctgaaac 453781 cgggcagcgc catcatcaat acgacatcca tcaacccgta cgtagggaac ccgacactga 453841 ttgattatac agcgacaaaa ggggcgatca atgcctttac aagaacaatg gcgcaggcgc 453901 ttgtcaaaga cggcatccgt gtaaatgcag tcgcgccggg tccaatttgg acgccactaa 453961 tcccagctac gttccctgaa gaaacagttg ctcaatttgg gcaagatacg ccgatgggcc 454021 gtcctggaca gcctgttgag cacgtcggct gttatgtgct tctggcatca gatgagtcct 454081 cttacatgac aggtcagacc ctgcatgtca acggcggaaa ctttgtgacg acataagagg 454141 gagtgagaca tatgggcatc acgaaagaag aagtgaacag ctactatcaa aaagcaggga 454201 ttgtattaac ggacgaggaa gtagaccaaa tccagctgat ggattacggc ttaggaaaag 454261 aaagaaaagt cgggctccag ctcttcgtct acgtcaatac agaccgttat tgttcaaagg 454321 aattggtgct gtttccggga cagacttgcc cggaacaccg ccatccaccg gtcgacggcc 454381 aggaaggcaa gcaggagacc ttccgctgcc gctacggaaa agtgtatctt tacgtagaag 454441 gagaaaaaac gccgcttcca aaagttctcc ctcctcagga agacagagaa cactatacgg 454501 tctggcacga aattgagcta gaaccgggcg ggcaatacac gattccacca aacacaaagc 454561 attggttcca ggccggggaa gaaggtgccg tcgtgacgga aatgtcatcg acgagcacgg 454621 ataaacatga tatctttacc gatccaagaa tataaggatg ggcttaacag cccatccttt 454681 ttgtattgaa aaaaacagaa tcatcgctat aatgggtaaa aaaggaaaga gggcgaggca 454741 atgttcactt gcaaggtaaa tgagcacatc accatccgat tattggagcc gaaggatgcg 454801 gagcggctgg ccgaactcat tatccaaaat cagcagcggc ttggcaagtg gctgtttttt 454861 gcggaaaatc caagcagcgc tgacacgtac cgagaaacaa tcattccaga ttggcggcgc 454921 cagtatgccg acctgaacgg cattgaggcg ggtctccttt atgacggcag cctatgcggc 454981 atgatcagcc tgcataacct tgatcaagtg aatcgtaagg cggaaatcgg atattggatt 455041 gccaaagaat ttgaagggaa aggcattatt acagctgcct gccgaaaact cattacgtat 455101 gcttttgaag agcttgagct gaatcgtgtg gcgatctgtg cggctgtcgg aaacgaaaaa 455161 agcagagcgg ttccggagcg gatcgggttt ctagaggaag gaaaggcacg ggatggctta 455221 tacgtaaacg gcatgcatca cgacctcgtc tactacagtc tgttaaagcg tgaatgggaa 455281 ggcgaaaaat aaagagcaca ctttcttgtt taaatcttcc ccggatgtgg aaaagtaaca 455341 gcggagacgt taaaaaggag tgattcgaga tgaatcagca agacattaaa caaaaagtgc 455401 ttgatgttct agatcaccat aaagtaggtt cgctcgcaac agttcaaaag ggcaaaccgc 455461 attcccgcta catgactttt ttccatgacg ggctgacgat ttacacaccg acaagcaagg 455521 aaactcataa agcggaagaa attgagaaca accccaatgt ccacatttta ttaggctatg 455581 attgtgaagg ttttggcgac gcatatgtcg aagttgccgg aaaagcaaag atcaacaatt 455641 cggcagaact caaggacaaa atatggagtt ccaaattaga gcgctggttt gacggcaagg 455701 atgatccgaa tctggtgatt cttgaaattg aaccggagga tatcagatta atgaatgccg 455761 gggagaaaac accggtctca ctcgaactat aaaaaatttg tgttttcagg ggcgatatgt 455821 tattatgaat agctagtaag aaaaataagc aaataaaaaa gaaagtaaac ttcttttttc 455881 tgttttgaga gagaagctta ccgcttccca agcagcataa ccagctgccc ttattctttt 455941 ccttcataac aaatcgcccc taacgatgag atggaaaaaa gacttttttg ttttacaatt 456001 cacaccggcg cggcttcgga gccgcagtga cgattgagag gtagggcttt cgttgtcttg 456061 tgttcaagaa atttccatgg tgtttacttt ccagaatgat tcttcggaac aatgctttat 456121 gaatctaacc cgcctgactt ggcggatgat ataatcttta tttgcgtata gaaaagaata 456181 agacaaaccg cccggcgtac gccggacggt ttttttattg caaaaaacac atcgtactga 456241 aacctccttg tcttctttcc agtcttatct ctaggatgaa attggaggaa gaataacgtg 456301 catgtcatta caacacaagt actttttatt ttttgttttt tattgctgat tcactcgata 456361 gaaaccttag cctatgcgac aaggctttcc ggagctcgcg ttggatttat tgcgtccgcg 456421 ctttctctgt ttaatgtcat ggtcatcgta tccagaatgt cgaatatggt gcagcagccc 456481 tttactgggc atttaattga tgatgctgga aaaaacgcac tggcgattgt aggggagcag 456541 ttccgctttt taattttcgg atcgacagtc ggcaccattt tgggcattat cctgctcccg 456601 tcttttgtcg ctcttttttc acgggcgatt attcacttgg cgggcggcgg cggctccgtt 456661 tttcaagtat tccgaaaggg attctcgaaa caaggattca aaaatgccct ttcctatttg 456721 cgtctgccgt ccatttcata tgtaaaagga tttcatatgc gcttgattcc gaagcgtttg 456781 tttgtcatca acatgctgat cacatcgatt tatacgattg gtgtgctttc ggctttatac 456841 gcaggccttt tggcgccgga gcgcagcacg acagccgtca tggcttcggg tttgatcaac 456901 ggaattgcaa cgatgctgct ggctattttt gttgatccta aggtatccgt tcttgctgat 456961 gatgtggcaa aaggaaaacg aagctatatc tatttaaaat ggacctctgt cacaatggtc 457021 acatcaaggg tggcgggcac actcctcgcc cagctcatgt ttattcccgg ggcctactat 457081 atcgcgtggc tgacaaagtg gttttaataa gaaaggctgg atcataaaga tccagccttt 457141 ttgcgcttcc ttatttatag ttccttaatc cgcggtcgta caaaaaattt ccgaatggga 457201 cgaaagcggc gatgaagccg gcagctgacc atttcagcgg ccatttgaca gagaaggttg 457261 cataagccaa gacaagcaaa tacaaaatga acaacccgcc gtgaaccgaa ccgacaattg 457321 tcaccgcaag cggaaggcct gcccaatatt taagcggcat agcgatgaac aacaggatta 457381 agagtgacat tccttcaata aaacccatcg tgcgaagtct tccgatcggc gtgtgcagca 457441 taaatcgccc tccttgtgga cacgttttca ttttatacta taaacaatcc gggggggcat 457501 atgacagctt tcaaaaaatg ttcggaaaac attcattttt acatgccttt tctagggaac 457561 tgtacttgtc atttacaaaa atacccgaga taatgtgtac aaaatcaaaa aagaaggatg 457621 ttgaaatgaa acttgaccag attgatctga atatcattga ggagctgaag aaggacagcc 457681 gtttgtcgat gagggaatta ggcagaaaaa ttaagctgtc gcctccatct gtaacagaac 457741 gggtaagaca gcttgaatcg tttggcatca tcaagcaata cacgctggag gtcgaccaga 457801 aaaaactggg gcttcccgtt tcctgcattg tggaagcaac cgttaaaaac gcggattatg 457861 agcggttcaa aagctatatt caaacattgc cgaatattga attttgctac cggattgcgg 457921 gtgcagcctg ctatatgctg aaaatcaatg ccgaaagcct cgaagcggta gaagatttca 457981 ttaacaaaac atcgccctac gcgcaaaccg tcactcacgt cattttctca gaaattgaca 458041 cgaaaaacgg gcgcggttag agagtgccgc gcgaagtctg ttataataac aggatgagcg 458101 tgaaagaaag agaagtgatc aagcatgtca aaaacagttg tattagctga aaaaccttca 458161 gtcggccggg atttagcccg ggtactgaag tgccataaaa aaggaaacgg ttatctcgaa 458221 ggcgatcaat atattgtgac ttgggcttta ggccatttgg tgacgcttgc tgatccggaa 458281 ggctacggaa aagaatttca atcatggcgc ctagaggatc tgccgattat cccagaaccc 458341 ttgaagcttg tggtgataaa aaaaaccgga aagcagttca atgcagtcaa atcccagctt 458401 acccgtaaag acgtcaatca gattgtcatc gcgactgacg caggccggga aggtgagctt 458461 gttgcgcgct ggatcattga gaaagcgaat gtccgaaaac caatcaagcg gctgtggatt 458521 tcatctgtga cggataaagc gatcaaggaa ggttttcaaa agctgcgcag cggcaaagaa 458581 tatgaaaacc tgtaccattc tgccgtcgcc agagcggaag cggattggat tgtggggatc 458641 aacgccaccc gtgcacttac cacaaaattc aatgcccagc tctcatgcgg gcgtgtgcag 458701 actccgacgc ttgccatgat tgcaaagcgc gaggcagaca ttcaggcgtt tacgcccgtt 458761 ccgtattacg gcatacgtgc tgcagtcgac ggcatgacgc tgacgtggca ggataagaaa 458821 tcaaagcaga cgagaacgtt caatcaagat gtaacaagcc gtttgctaaa aaatctccaa 458881 ggaaagcaag cggtcgtagc tgagctgaaa aaaacagcga aaaaaagctt tgcgcctgcg 458941 ctttatgatt taacggagct ccagcgtgac gcccacaagc gcttcggttt ttctgccaaa 459001 gaaacgcttt ctgtcctgca gaagctatat gagcagcata agctcgtcac atatccgcgg 459061 acggactcta gatttttatc cagtgacatc gtcccgacgt taaaagaccg tctggaaggc 459121 atggaagtaa aaccgtatgc ccaatatgtc agccaaatta aaaaacgcgg cattaaatct 459181 cataaaggat atgtcaatga cgcgaaggtg tcagaccacc acgcgattat cccgaccgaa 459241 gagccgctcg ttctcagcag tctgagtgat aaagaacgaa agctgtatga cctgattgcg 459301 aaacgtttcc tggctgtatt aatgcctgca ttcgaatatg aggaaacaaa ggtcatcgca 459361 gaaatcggcg gagaaacctt tacggcgaaa ggcaaaaccg tgcagtcgca agggtggaaa 459421 gccgtttatg atatggcgga agaggatgat gagcaggagg atgacagaga tcagacactt 459481 cctgcgcttc aaaaaggcga cacacttgcc gtccgcacgt taacggaaac aagcggccaa 459541 acgaagccgc ctgcccgctt taatgaaggg accttgctgt cagcgatgga aaacccaagc 459601 gcgtttatgc agggagaaga aaaaggcctc gtcaaaacgc ttggagaaac aggcggcctc 459661 ggcacggtgg caacgcgtgc cgacattatt gaaaaactgt tcaacagctt tttaatcgag 459721 aaaaaaggcc aagatatttt tatcacatct aaaggaaaac agctcctgca gcttgttccg 459781 gaggatctga aatcaccggc cttaacagca gaatgggagc aaaagctgtc tgcgatcgcg 459841 gccggcaaat tgaaatcggc tgtttttatt aaagatatga aggcttacgc tcaccaaacg 459901 gtaaaagaaa tcaaaaacag cagccaaacc ttccgacatg acaacattac gggaacggca 459961 tgtccggaat gcggcaaaat gatgctgaaa gtaaacggca aacgcgggac gatgctcgtg 460021 tgccaagatc gtgaatgcgg aagcagaaaa acgattgccc gaaaaacaaa cgcacgctgc 460081 ccaaattgcc ataaaagaat ggagcttcgc ggccaaggcg agggccaaac ctttgcgtgt 460141 gtgtgcggtc accgtgaaaa gctctctgta tttgaaaaac gaaaaaacaa agacaaagcg 460201 cgtgctacca aacgggacgt atcctcttat atgaaaaaac aaaataaaga tgagccgatt 460261 aacaacgcgc tggcagaaca gctgaaaaaa ctcggtttgg ataaataata aaaaaacctg 460321 tgcctatcgc acaggttttt tattggactt aggtcctgtt ttcttaatgt tcaaaaaggg 460381 aaaaaaaagc tagcaatctg catttttttt cttttatagt aaatgtactt tgtaacatgg 460441 cagtcatatt ttcgtctata actatttgtg agcgtctgat ttgcttcagg cgacaaaggg 460501 ggatttgcct gtgaggcatg tactaattgc tgtcatctta ttcttcttat ctatcggact 460561 ttccgcaggg tgtgctgaag ctggaaacaa gacccaaaat cagtcggcga cagaagtgaa 460621 tgccagcccg ctccagccgg cggaatattt catctatcac aatttaatga atgacaaagg 460681 gctgatcaaa accgattttt cagaccagcc ttcttacttg tcggaatctc tcggactgtg 460741 gatggagttt ctgctcagca aaaatgacgc accacatttc caggatcaat atcagcatct 460801 gactgattca tttctgatga gcaatcactt ggtgacgtgg aagattcaaa atggccaagc 460861 gagcgggacg aatgcgctga tagatgatat gagaattatg ctgtctcttg accaagccgc 460921 cgcaaaatgg ggccgcagcg actacgcgca aacggctagg gatatcggca cgtctttgaa 460981 gacatacaat atgaacaacg ggttttttac agacttttac gactcacagg ccgcttcaaa 461041 ggatgtgacg ctttcatacg tcatgcctga tgccttagct gtcttaaaga agaatggaat 461101 catagacgaa gaaacagaac agcggaatgc caatgttctc tattcagctc ctttaaaaaa 461161 tggctttctg ccgaagacat acagctcgga gacgaaggaa tacacatatg atagtgaaat 461221 caacctgatt gatcagcttt acgctgcttg gcatttgccg gaaggggatg aaaaagcatc 461281 tgttttagcg gactggatca agcaggaatt tcagaaaaac ggaaagctgt acgggcggta 461341 ttcggcatat acgaaggagc ctgccgtcca atatgagtct ccatccgtat atgccttagc 461401 cgtattgttt ttgacaaaac agcatgaaaa cagttctgtc atcaaagcca tatatgatag 461461 aatgaatgac tttgaaattc atgatccggt gaaatcgtat tatggaggct atatgagcgg 461521 cactcagacg cattcatttg acaatctgct gccgctgtta gccgaaagga agctttttaa 461581 tgaaaatatc attcagtgaa tcacaaaaat tatttgctta tttttcaggg ctcatcgcgg 461641 ccctgtcttt gtttatttat tatgtgtcag cccagcaatc agaaggtgct ctgatccttt 461701 gcatcacatt tggcgtcatc gccgcaggca tctggttcgg cccgatttac gcgctggcag 461761 tgaccttaat cgtactcttt gttctcggca ccttaatgat gtttttccag actggacaga 461821 catcgctctt tccggctgag gaagggctgc gaatgcttgt cgtgtgggga atcgcgcttt 461881 tgctgttttc ttttatttct ggaagaatcc acgatattac agcagagctt cggcgctcaa 461941 tgacacggct tcaatccgaa attaaaagct atgttgctgt tgacagagtg actggttttg 462001 ataacaagca aaggatgaag ctggaacttt cagaagaaat caagcgggcg gagcgctacg 462061 gcaattcttt tgtgtttttg ctgctccata tgcattattt caaagagttt aagtctttgt 462121 acggtgaaaa agaaacggac cgcctcttcc aatatgtcgg tcagcaaatc aggacaagcg 462181 ttcgggaaac ggataagaaa ttccgtccct ctgacgagcg tatcgggatc gtgctgacgc 462241 acacgcctgc tgaacatatg ccggccgttc tgactaagct gaagaaacaa ttggatacat 462301 atcagctgga aaatggaaag tatgtgtcgc ttacgttcca cgtttgctat ttgccctacc 462361 gcaacgatat ccaaacagct gatcaatttt tagaagaact ggaaaacgag atgatgatga 462421 atgaactata aaggaatcac attgctatgc gtcatgatgc ttctattttc agctattgcg 462481 tcttttcccg tttctgcgca agcgaaagat caggatgccg gcattctcat catctactca 462541 accttggacg gcaaagagtc gtcacaagtc aaaatgctcg atttgcttgc gggccacttt 462601 acatcccatg tgacagtcaa aaaagattca gacgttgaag cgtcggattt caaagggaaa 462661 gaccatgtga tttattacgg ccaaacgaaa agaaagctca gccaaaaatt gctgtctctt 462721 atcagcggcg tgaaaaaacc ggttgtcgcc attggctata acgcaggcca aatcagccaa 462781 ttttctgggc tttcattagc ccgcaaagaa aatgtgtttc aggttcacag caggtcagaa 462841 aaggccgatg tgtctctgga aagcgggctt aacgtgctga gtgtatcagg cctgaaagga 462901 acggcgcttt acaccttcaa agcggatgaa ggcacaacgc attcttttat atggaaaaca 462961 aaaaaaggga atgtgtacat tggattaaca aatttgttaa atgacaattt gatcgtggcg 463021 aaacagctca gagaagcttt cggagagaag gcggggacga cgttattgta tttgcgtctc 463081 gaggatatca gcccgatgtc tgatgaaaaa ctgctgcttc aagccggtac atacctgcat 463141 aagcggcata ttccttttat cctggcggtc attccggttt acttgaatcc ggaaacaggc 463201 gacaaagtgt atttgtctaa tcaaccgaag atggtcaagg tgctgaagaa gctgcaaagc 463261 atgggcggca gtatcatagt tcacggctat actcacgctt atcgctacag tgaaacagga 463321 gagggatttg aattttggga tgcaaaggcg gatcagccga ttacatccgg aaatgccgaa 463381 gaccccccgt ccattttgga gaaagaacag gacttcccga acgaacaagc ctatcacagc 463441 tatcttgaac catttcggga aaaggaagaa acgtatacaa aacaaaaact gacgcgtgcc 463501 attgaggatt tgacatcatc gggtctttac ccgctggcgt ttgaagcgcc gcattacacg 463561 atgtccgaat atggctatca aatcgcctcg cagtatttta caagcatttt cggccaggtc 463621 cagctcagca gcacaacatg gaaaacatcc ggtgcacctc cgtttgtgac tgctccttcg 463681 atgctgcacg gaatgacgct ttatccggaa acgatcggct ttgtcgacac atcgaagcaa 463741 aacccgctcg gtgagatgga ggagcatatc tcccagatga ttgattttga aggcggagta 463801 gccggaggat tttatcaccc gtaccttggg atgaaatatc tgcctgagct ggttgatcag 463861 atggaacgca ttccagacag tgaatggctt gatttaaaga aaacgaaaca aaccgtcaaa 463921 acagacaaag tggaaattca tacaagcggt gacggaacga ttcaggtgaa aaacggcgta 463981 agccccattt acgagttttt cgatcatcac cggcaaaccc ctctggaaaa ggcgttatgg 464041 attctctccg ctgttgtgct cttatttgtc atcatgtttg tcagttatac gttttacttg 464101 agagccacat tgaaaaaacg aatttttaag gagagaagaa gccttgggta atacgctgtt 464161 ctttatctcg ctaagtttaa tatgggttat gcttctctac cacatgttcc tcatgcaggg 464221 cgggtttcgc cactatatga ccttcgaacg gaatatcccg aagtggagag aaaatatgaa 464281 ggaactgccg aaggtcagcg tcctcatccc ggcgcataac gaagaggttg tgattcggca 464341 gacgctgaag gccatggtca acctttatta tccgaaggac cggctggaga ttatcgtcgt 464401 taatgataat tcatcagacc ggacgggtga tatcgtcaat gaattttccg agaaatacga 464461 tttcatcaaa atggtgatta cgaagccgcc aaatgcagga aaaggaaaat cctctgcact 464521 taactcgggt tttgccgaat cgaacggcga tgtgatctgt gtgtatgacg ccgacaacac 464581 gcctgagaaa atggccgtgt attacctcgt gctcggcctg atgaatgacg aaaaggcagg 464641 cgccgtggta gggaaattcc gcgtcatcaa tgcggcaaag acgctgctga cgaggtttat 464701 taatatcgaa acgatctgtt ttcagtggat ggcccaggga ggcagatgga agtggttcaa 464761 aatcgccacg atcccaggca ccaacttcgc gatccgcaga agcattatcg aaaagctcgg 464821 aggctgggat gacaaagcgc tcgctgagga tactgagctg accatccggg tatataatct 464881 cggctatcac atccgctttt tccctgccgc catcacgtgg gagcaggaac cggaaacatg 464941 gaaggtatgg tggcgccagc gcacccgatg ggcgcgcggc aatcaatatg tcgtgctcaa 465001 atttttggcg cagtttttta agctgaaacg aaaacggatt atctttgatt tgttttattt 465061 tttctttacg tacttcctgt ttttctttgg cgtgatcatg tcaaatgcga tttttgtagt 465121 gaatttgttt tatgatttgc atttgtctgt tggatttttg gcaatgattc tctggatttt 465181 ggcgtttttc ttatttatga cagaggtcat gattacgttg agcattgaaa aaacagaaat 465241 gaacaagcaa aactttttta tcgtatttct catgtacttc acatactcgc aggcatggat 465301 tgtgcttgtt atctactctt tattcgtaga aatcaagcac cgtttattca agcaagaggt 465361 caaatggtac aagacagaac gatacaatca acataaaagc gggtgacctt tttgaaacaa 465421 ataatgattt ttctcacaag cttcatgctg ctggcgatga ctggacaaac ggctcttgcc 465481 aaagacgtac aggtcagcgg ttcgctcctt gggaaaagca gccaagaaca agccaaacag 465541 caggtgctga caagcgagct gattacactg tatggatcaa aagacagcgc agagctgacg 465601 tatcagatcc cggcaggcgc ctcttcgggc aatcagcaat tggtaatcga atacgaggca 465661 tcaaatcttt taatttctcc atcatcgtta acggttgtca ttgatgatga accggtcaag 465721 acgttaaagc ttgatggtga ttccaaacgg aaaacagtga agctgaatct gaataaaagc 465781 cagtctgcgc aaggctatca caacgtatcg ctgaaattct acggcgtaat gaaagagggc 465841 gtgtgcgtca gacaggatac atcaggcaac tggatcaaaa tttatccgga cagccggctg 465901 acacttgctg acagcagtga agcgaaggga acgtcgctgg accattatcc gtatcctttc 465961 gcccaatctg gaaatacagc ggaagaaaca gctatcgtca ttccggataa cccaagttca 466021 gcagaaatag aagctgctgt taaaacagaa ggctatttga aaacggtgga cagcagtgtc 466081 agtattgcgt atgtcacgga atctgaactg aaaaaaatcg ataagccgac gattgttatc 466141 ggcgtggaca agcattggaa cggcaaagtg aaaaaactgt tgaaacaagc cgggctacag 466201 gcaaaaggag aaaaccttct gcttgcggag cgggtgctga aagcagaggg caaacagcag 466261 ccggttctgt ttgcgcaagc ggcgtccgag gacgcgctca caaaaaaaat cagcgtgatg 466321 acagatcaga catatacagg ccagctcagc ggcgatacac tttcaatcag caagcttcag 466381 cagactgaaa aaaaagaaag cgataagctg acccttgaga attttggagc gggtgatatc 466441 acaattggag ccgacaaaac atcttcagca cattattttt atccggcttc ggctgtttta 466501 gatgaaaacc aatcggcgaa gctgtcgctt aaactgaaaa agtctgaaac gattcaagcc 466561 tcaacggctg aaaacgagtc agcctctcag gctgcagaac tgaaagtgat gatcaacggc 466621 cagccgcact cggtccggct tgatgaatta ggaaaagaag ataaaaacgg attctatcat 466681 gtcacagtga aagtggaccc taagctgctg caaaaaaacc gctacattga tattcagttc 466741 gtcacgaccg gtttaaagga aaacaaccct tgtaacacca ctgatgaaga aaagtgggtt 466801 tttatcgata aaaacagtac attatcatac gccatcaaag gcatgtcccc gtcagcggat 466861 tttcaagagt ggccgctgcc ttacgccgga aaccaggatc aaacaacgtt aatcgtgctt 466921 cctgacaccg taagccaatc gaagctagag gagctttctc tcgtaacaga atcctttggc 466981 aacgaagcac agcattcata tacggtaaag aaatcatctg acgttacagc aaatgatgcg 467041 aaaggacgaa acctcatttt cataggaggg atcaatcaat tttctcttct gaaggagaaa 467101 tcatcagatc tgcttgtgcc gcaggaaaag aacggctcgt ttgatgtatc tagtttcgag 467161 atgctgaatg agacgacaaa acaagtggta tttacccaag catcggtttg ggattcacgc 467221 tatacaatgg ctgtctttgc accgtcaaaa ggagatggca cggctgtcac aaaagagatc 467281 atcagttatc tgaacagcaa cgatgagtcg gcaaccgtcc ttaatgaaac aaacagccag 467341 caggtgttta caaaccacca gcagctcaaa tcggaaacaa acagttccga tgcagaacaa 467401 ccaacacagg atcatagcca gaaatggatg tatattggtg tgctggcact cattatggtg 467461 gttgcggcag tgttcatttg gattgccgta agacgcaaaa aaagaaagac agatacagaa 467521 taaaacagag gcgattttag cctctgtttt tttatttttg gtaagtaaat tccatttgtg 467581 gaacctgtca ttttattttt ttctctcagc caataagcct ctttacaacg tgcgggaacg 467641 ggagtatgat ctcttttaga aaacaaatcg cttaatctga aatcagagcg ggggacccaa 467701 tagaacggct ttttgccgtt ggggtgaatc ctttttaggt agggctaact ctcatatgcc 467761 cgaatccgtc agctaacctc gtaagcgttc gtgagaggag atgaatgaaa cctgtgttcg 467821 atgttatggc acaggggcat ccgtttgcct ctgtgttttt tgttgttcat ttttgaatgc 467881 aaatcgcata cagagacatc atagcagaaa ggactatcat caacatgtga gagcaagaca 467941 ctgatggatg ttttattgtt ttaattgaaa aatgagaaat taaaagggga agacatcgat 468001 gtatcattca atcaaacgtt ttttgattgg gaaaccacta aaatcccaag cagctggaga 468061 gcaaaaactg acgaaattaa aagccttggc tatgctttcc tcagatgcgc tgtcatctgt 468121 cgcatatggg acagaacaaa ttctaatcat tttggcaaca atcagtgcag ccgcattttg 468181 gtactccatt ccgattgcgg ttggcgttct catcttgctg ctcgcactga ttctttcata 468241 caggcaaatt atttacgctt atccgcaggg cggcggggcg tatatcgttt ctaaagaaaa 468301 tctcggtgaa aaaccgggat tgattgcggg cggttcattg cttgttgatt atattttaac 468361 agtagcggta agtatttccg caggcacgga tgccatcacg tcagcctttc ctgcattgca 468421 tgattatcat gtgccgatcg ctatttttct cgtgttagtg attatgattt tgaacctgcg 468481 cgggctttcg gaatcagcat ccatacttgc ctacccggtt tatctgtttg tggtggcgct 468541 tttggttctc attgcagtcg ggttgtttaa acttatgaca ggacaaatag accagccagc 468601 ccatcataca tcgctcggca cacctgtagc cggcattacg ctatttttgc tgcttaaggc 468661 tttttcctcc ggatgctcag cgttgaccgg ggttgaggcc atttctaatg cgattcctgc 468721 attcaaaaac ccgcctgcgc gaaacgcggc aagaacgctt gcgatgatgg ggattttgct 468781 ggcgattctg ttttccggca tcacggttct cgcgtacggg tatggtacgg cgccgaaacc 468841 tgatgaaaca gtggtttcac aaattgcgtc cgaaaccttt gggcggaatg tgttctacta 468901 tgtcatccaa ggtgtcacat cgcttatttt ggttcttgcg gcaaatacgg gattctcagc 468961 cttcccgcag cttgccttca acctggcgag agaccagtat atgccgcgaa tgtttacagt 469021 caggggcgac cgcttaggct tctcaaatgg gattatcttt ttaggctttg cctccattgt 469081 tctcattatc ttattcgggg gacagacgga gcacttaatc ccgttatatg ctgtgggcgt 469141 atttattcca tttacgcttt cacaaaccgg catgtgcatg aaatggatca agcaaaaacc 469201 aaaaggctgg atcggaaaaa tgctgatcaa ctcctgcggc gctctgatat catttatggt 469261 tctatccatt ctgtttgtga cgaagtttaa tgtcgtatgg cctgtgttaa tctttatgcc 469321 tatcgtcgtt ttgctgtttt ttgcgattaa aaatcactat actgcggttg gtgaacagct 469381 tcgcatcgta gacaaagagc cggaagaaat caaaggcacc gttgtgattg tgcctgtggc 469441 cggtgtcacc accgtcgtgc aaaaatcgat tcactatgcg aaatcactgt ccgatcaggt 469501 gatcgccgtt cacgtgtcat ttgacagaga acaggaaaag aaattcgaaa aacgttggga 469561 agagcttaat aacggagtgc gtctcgtgac gcttcactcc tcttacagaa gccttgtcca 469621 tccgtttgat aagtttttgg aaacagttga ggcaaaagcg aagaaggagc agttttccgt 469681 tatggtgctg tttccgcaat ttataacgaa aaaacgctgg cacaccatcc ttcacaacca 469741 atcggccttc ctcctcagag tccggctgtt ctggaaaaag gacataatgg ttgccacact 469801 gccgtatcat tttaaaaagt aaagctctag gaccaaggga atcaccttgg tcctttttag 469861 cgggaaaagg aggtatgggg gtgtatacac aaggtgcttt tgtgatcgta ttgaacgaaa 469921 gtcagcaaat tctgctggtg aaacgaaaag atgtccctct atgggatttg ccgggcggca 469981 gggttgatcc cggggaatcg gctgaggaag cggcagtgcg ggagatattg gaagaaacgg 470041 gatacaatgc agcgctttct gcgaaaatag gtgtttacca aaggccaaag tttcaagatg 470101 aacagcatct gtttttcgga agcattacag gcggacaagc aatggctgac ggcacagaga 470161 cagcgggatt aaagtgggtt tccccggggc gtttgccgct ttttatggtg ccgaatcgaa 470221 aaaggcagat caatgatttc aagaacggcg ctcaagatgt aaatgtcacc gtcaaggata 470281 gcgggttgct cgcggcgatc gacctgttga aaagaagact gggcaagtga ttcaggtctc 470341 cgggttttaa agcctttctc ctgtggtatt gaaaaaagga aaaaggagga tacgttatgg 470401 cacacaaaac tgcaggacaa gcaatgacag agctgcttga gcaatgggga gttgatcatg 470461 tatacggcat ccccggagac agtataaatg agtttatcga agaattaaga cacgaaagaa 470521 atcaactgaa gttcattcaa acccgccacg aagaggtagc ggcactggca gccgcggctg 470581 aagcaaaact caccggcaag atcggagtct gtctgtcaat cgcagggccg ggagcggtgc 470641 acttattaaa tggtttatat gatgctaaag ccgacggcgc ccctgtgctg gcgattgcag 470701 gacaggtttc ttctggcgaa gtcggacggg actatttcca ggagattaag ctggagcaaa 470761 tgtttgagga cgtggccgtg ttcaacagag aggtacatag cgcggaatca cttccggatc 470821 tcttaaatca ggcgatcagg accgcctaca gcaaaaaagg cgttgcggta ttgagcgtgt 470881 cagatgattt gtttgcggag aaaatcaaac gggagcccgt gtatacttca ccggtgtata 470941 ttgaagggaa cctagaaccg aaaaaagaac agctcgtcac ctgcgcccaa tatattaata 471001 acgctaagaa accgattatc ctggcagggc agggaatgaa aaaggcgaaa cgggagctct 471061 tagaatttgc ggacaaagcc gccgctccga tcgttgttac actcccggca aagggtgttg 471121 ttcccgataa gcacccacat tttctcggca acctcggtca gatcggaaca aagccggctt 471181 acgaggcaat ggaggaatgt gatttattaa tcatgctcgg aacgtcattc ccgtaccgtg 471241 attatttgcc tgatgacacg ccggcgatac agctcgattc agacccggca aaaatcggaa 471301 aacggtatcc ggtgacagcg ggccttgtct gtgattcggc tctcggtttg cgcgaattga 471361 cagagtatat tgaacgcaag gaagacagaa gattcctgaa tgcctgcaca gaacatatgc 471421 agcattggtg gaacgaaatt gaaaaagatg agacagaggc aacaacaccg cttaaacctc 471481 agcaggtcgt ggcccgtctt caggaagcgg cagccgatga tgcggtgctc tctgtagatg 471541 tcggcactgt gacagtctgg atggcgcgtc atttcaaaat gaacgcgaat caggatttca 471601 tcgtttccag ctggcttgcg acaatgggct gcggcctgcc gggagcgatt gcagcgagct 471661 tgtccgaacc ggaacgccag gcgatcgccg tctgcggtga cgggggattt tccatggtca 471721 tgcaggacct tccgaccgcc gttaaatata agctcccgat cacagtcgtt attttaaaca 471781 acgaaaatct cggcatgatt gagtacgagc agcaggtcaa aggcaatatc gactatgtca 471841 caaaacttca aaatgtcgac tatgccgcat ttgcagaaag ctgcggagca aagggcatca 471901 aagtgaccaa agcggaagag cttgcgccgg cttttcatga ggcgctgcac tctgaccaac 471961 cggtcgtagt ggatgtcatg attggaaacg aaccgccgct tcctggcaaa atcacctacg 472021 ggcaggcgaa aggctttagc aagtacatgc tgaaaaactt cttcgaaaac caaaaatttg 472081 aaatgccgtc actgaagaaa agtttgaaac ggttatttta aaaaaacagg ggccctaaga 472141 gcccttgttt tttttttttt ttttggaaac aaatgtattt tcagcatgtt tgaattcata 472201 aaatgatcgg tatatgtatt aggaactgat ttcgccatac tcgaaacaga caaaaggaca 472261 aatgcatctt gtttcaaagg aagatgcatt tgtccttgca tgcttattct tatcaaatct 472321 tacagaactc ttctcataat aggttatttt tcttttttct tcagcccgaa gaagaaagga 472381 aaagcagaac cgaccaagaa ggtgccgaat aaaaacatgc cgccgataaa cacgtggaaa 472441 tttgtgtgtc cggccgtaaa cgccgtgatt agggaaatga tactgagcac gatcatggca 472501 atgccgggcg cgactctcat ttttcccttg gatttatggg cagcaacaga acataaaatg 472561 ccgataacaa taggaacaat ccacaaataa aacagaataa atactgacat catcaaaact 472621 ccgatttttc ttctatcata acaaatttct gtcaaaaagg gtatcaatga gcttttgcgg 472681 aaaaataaaa accggcttta gaagccggtt tttttatcga aacgtatcta caattaaaaa 472741 cacattcaaa gcaacgatca atacagcaat cagccaagac accactgtga tccatttggc 472801 gttgatcaga gatcccatga tccgtttatt gcttgtaaac ataataagcg gaatgagggc 472861 aaaggcgatc ccgaaggaca gcacgacctg gctcagtacg agagcggtcg tcggattaac 472921 acctgacgcg atgatcaaga tcggcggaat gatcgtgata aaacgccgta catacagcgg 472981 aatgcggtag ttgataaatc cttgcataat cacgtcgcct gaaagtgtgc cgacagacga 473041 actggataga ccggcaacga gcagcccgat cccgaacaaa gccgcagaca tagggctgac 473101 aagatgtccg aattgctgaa atgcgacgtc gagatcctca acaaacaggc cgtttttgaa 473161 gaataatgcg gcagccacaa tcagcatact tgcattaata gcccctgcaa tcagcatcgc 473221 tattaaaata tcaataaatt caaacctaaa gatttttttc cgttctgcat cagttttgcc 473281 aaccacccgc cgctgtgtaa gggcagagtg taaataaatg gcgtgcggca taacagttgc 473341 gccaagaata cccgctgcaa gaagcacact gtcggtgcca tgaaacgccg ggacaaaaag 473401 gcccttcatc actgacacgg catcaggctt tgcgaaaaag gtctgcaacg caaaggcgat 473461 cacgaccaca aacagcatac cggcaatacc tgcttcaagt gagcgataac cacggcgctg 473521 aagctccaat atcgcgaaag aaccgatcgc cgcaataata gacgcttcaa gcatcggaat 473581 gccgaacagc aaatacagtc ccagagccgc tccgataaat tccgccagat cagttgcgat 473641 aatgaccaac tcgccctgaa tccataatcc gatcgagaca ggcttcggga attcttcacg 473701 ggcaacctca ggcagatttt tgcctgtcgc aataccgagt ttggcggata gggattgaat 473761 taaaagcgcc atgatattgg aaaataagat cacccataag agcatatatc cgtatttaga 473821 acccgccgaa atattcgttg cgaagttgcc gggatcaata taggcaatgg ctgctataaa 473881 tgcagggccg agaaaaggga gcagccctct gaatcctctg attttcccgt caagcgcatc 473941 ttggacggct ttggaacggg gagattgtgc tgtgatgtcc ttgttcatca tgtctcacct 474001 gaattctgtt tgtttttgcc gtacaacaaa gagtttcctt aaggcaaatt attttatcta 474061 catcatatga ccatcccggt ttcttgtcaa ccgaaaatgt tcaaaataca cttctgaatt 474121 tttccctgtt atgtaacatg atatgtaggg attcgtgata aggtcccata taaaaagaca 474181 tcgtttcatt tcgaaacgat gcctcctgta tctaatgagt ctaggcttcc ttccgcagcc 474241 cgcggaatat aaggcccagc aagaacacga agatggctgc cccgatgatg gccgggaaaa 474301 tagcaaagcc ggcgaggctc ggtccccatg tgccaagaag tccgtgccca atccaagcgc 474361 cgatcagccc ggcaatcata gagccgaaaa ttcctcccgg cagccggttt cctacaatgg 474421 cgctcccaat taatccgata acaattgcaa caactaatga aaccaaaaag ctaagcatca 474481 tgatcacctc tcataaatga tttaccaatc aataaccgct cctgatcatt tcgaaacact 474541 tgaaagcata ttcctttatg atcctgtttt aatctttctc tgcacactgc cgtcagctaa 474601 atgaacaatg acctcagtgc ctttatgcgc cgcgatttcc tttgcccgtt caatcgcttc 474661 tttctttgta tccttgattt cagacacacg tttggcgccc tcggctttga ctgcccagcc 474721 ttttttatgc ttaataacat gctctgcttt attcatgagc tcggggccgc tgccgctgct 474781 tggatcagca tcgcgttctg tctcatcatc atgcgtcagg aaatcatcaa tttcatctgt 474841 agaggcgttt tccgcccatt ccttcgcttt gcttgtcgca attggaatcg cgcgcccttc 474901 ctcatagcct tcatcaatca tcgcattcgc aatgtctatc gccttttttc tcaccggctt 474961 ctcaagattt tttaatgaag caggataatc cttcatcgac caaggcatgt ctatcactcc 475021 ttttcctttt ataaaaatgg tacccgcagg tgaaaaataa aaacgcatcc gaaaaaatga 475081 aggtatacta tatagtagaa aaaacggaag ggaagtgcgg gttgggtgcc aacagaacga 475141 aaagaagact tacatcagca attaaaagag atagagaaat gggaaaaaga tcagcaaaaa 475201 gtctggtttt gggaaaagct cagccgtctc ccgtttcaac tcctggacaa gctgacacca 475261 gaattcatcc agaaaaagat cggcaagctc ttggatgagg tcggcagctt tgttcaaaca 475321 ggcggacagt acctgacatc tgaaaaacag attatcagga tgtttcaaaa gaaactgccg 475381 gaggagatct ttgaatcgct ggaggacatc cggaaagcgc ctcttcctgt catggatgaa 475441 attgcggaag gaatgggcaa aaacagaacc aacgcagcaa ccgttcaagg cgcgacaacc 475501 ggtgtgggcg gcgtgtttac gctggcggca gacattccgg cagtgcttgg cttatcacta 475561 aaaacattac aggatatcgc agtcgcatac ggctatgacc caaaggagaa aaaagaacga 475621 gtcttcattg tgaaatgcct gcagcttacg tcggctgatg ttgtcggcaa aagatcgatt 475681 ttgcaggaat taaaacacta cgatcaagac cgtacatata agaatgtcgc ttctcaaatc 475741 caaggctggc gagaagtcgt tttgggctat cgagacacgt ttggctggaa aaaacttttc 475801 cagatagtgc cggttgccgg aatggttttt ggcgccgctg ccaatcgctc aacattaaac 475861 gacattaccg agacaggcat gatgctgtac aaaaagaggc gcattcttga acgactgaaa 475921 gaaacagaac gagagatgga atagcagaaa gcagacggac accgcgatcc gcctgctttt 475981 tttagtggaa acatacccaa tgtgttttgt ttgtttaaaa gaattgtgag cgggaataca 476041 acaaccaaca ccaattaaag gaggaattca aaatggcaga caataacaaa atgagcagag 476101 aagaagcagg tagaaaaggc ggagaaacaa caagcaagaa ccatgacaaa gaattctatc 476161 aagagattgg tcaaaaaggc ggagaagcca ctagcaaaaa ccatgacaaa gaattctatc 476221 aggaaatcgg cgaaaaaggc ggagaagcca ctagcaagaa ccatgacaaa gagttctatc 476281 aagaaatcgg tgaaaaaggc ggagaagcca ctagcgaaaa tcatgacaaa gaattctatc 476341 aagaaatcgg ccgaaaaggc ggagaggcaa caagcaaaaa tcatgataaa gaattctacc 476401 aagaaattgg ctcaaaaggc ggaaacgccc gcaacaacga ctaatcaaaa gcataaaggc 476461 agacaacctg taaataaaaa agcgatccgg cacatcagct ggatcgcttt tttttggaat 476521 cttctcaatt tatgccgcta ttgagataca ataagtgaaa aaggggtttt cgctaatgtc 476581 caagatgcaa aacttgctcg ccatcgcaaa tgaagtcaaa gaaaagcacg ccaatttttc 476641 aatctcagag gtcaacgacc actgcgtgcg ccttgcggtg tttacgggag aatatgactg 476701 gcaccatcac cctgactcag acgaattgtt tattgttctt gaaggggagc tgctgatcga 476761 ttttaaggac aaagaaaccg cggtgctcaa agcaaatgac agcctgctga tccctaaagg 476821 cacggttcac cgcacacgct cttacgtcag aacggtaaat ctctgtgtgg agcataaaca 476881 agccgaaacc gtcatcatag aggagcagcc atgctaatca aaaagatgat atgtgaagta 476941 gatgctgcaa acgctgaagc atttgcaaaa gcgcagtcac agtgggaagc gttatcgcat 477001 ataagcggct ttatcaaaca ggccggcggc tggcgaaaaa cgatagacga gccgctcacc 477061 gcagaaatca tcagtgtatg ggaaaacaga gaagcctatg atcattttat ggagaacgaa 477121 catgacagca tatacgagga aaacgatcag aaggctgtaa ttctttcgat agaggtgacg 477181 gtgtacgaag aggataaacc gttcgttcac gatctgttac ataaccccga tatccggtac 477241 gaaccaaact ggacggttct gaaggcataa tcaaagccca aaacatcatg ttttgggctt 477301 gtctctttac tcgcgtcccg gaagtgtatt atgaacaaaa ggcggtgctg gttttaactc 477361 cggtttttct ccaaacgttt ttgcttcttt cacatattca aaggcttctc cgtccggcgc 477421 tttttcattc agccagtttt gctcggcgct tacttcgcct tcagagaaat tgataagctg 477481 atgtgagaac tcttgttttt cgagcgcttt cgggaatgta cccggcacaa ccggaccttc 477541 ctgtgcttct aattctttaa tggcggcgag ccattggttc tggtgcatcg tgtcacgcgc 477601 cagcaggaag ctgagcatat ctttgacgcc tttgtcatcc gtcatttcaa acaggcgtgc 477661 gacctgcaga cggccctgag attccgcatt caggttggcg cggaagtctg ccagcaggtt 477721 tccgcttgct acgatataac cgccgctcca aggtacgcct gtactgcttt ccggcatggc 477781 gccaagtcct gatacaatcg catggtgagg gttcatgccg cctaggatgg agccgatgac 477841 cggatcttca gcagcttttt cctgctgatc aagaggggca tcctcaagaa gtctggcaat 477901 catcgttgcg atcatttcaa catgcccgag ctcctcagtt gccgtatcca tcagcaagtc 477961 cttgtatttt tcatttcctc ttgtgttcca gccttgaaat aagtactgca tggcaactga 478021 aatttctccg aattgcccgc ctaaaatttc ttgcattttt ttagcgaata atggatctgg 478081 acgatctggt ttagcaggat gctgcagcat ttttgtgtgc ttaaacatgt acccatctcc 478141 tttttcgttt atctcttttt atatttccga tcgatagaaa gataaacgaa aaacagcgta 478201 tcgagatggg aactatgaat cttttcgcag ctccaacagt tcccggatca gctcccggcc 478261 aaagatgggc tcatactgcc ggtaaacagg gtcaagacgc ttcatccatt cttgtttctc 478321 tttatctgac agctcataaa tatgtatagc agaattcttt ttgatttctt ccagctgctc 478381 cttgttcatt tgttcggcat acgtttcatt ccactccgtt gtctccttca tcgcttcagt 478441 caaaatgcgt cttgtttctg gtgtttgcgc cttccagaag tgttcatcag tcatgacagc 478501 gtagccgaga taaccgtggc tgcttattgt caaatagtcc tgaacattat aaaatttttt 478561 agaatagatg tttgaaattg tattttcttc gccatcgact acattgtttt ctaacagctg 478621 aaaggtagaa ttgaaggatt cctgatgagg tgttgcgcca agcagcttga actgatcctc 478681 aatcacatcg ctttgcataa tgcgcagatc ctgccctttt aagtcatccg gtgttttgac 478741 cggcccttga tttgttgtga tttgcttaaa gccgttcgtc caataggcca atcctttcaa 478801 ttggtttttc tttagagaat caaacagctg tgtgccgatg cttccgttca gccctttttt 478861 gacggcgttg taatctgtaa atgcatacgg cagatccagc actccccatt caggcgagag 478921 catgccgagc ttcgatgtgg agggggcgat aaattgaaca tcgccgtttt gcaatgcttc 478981 aatttcttca atgtccgagt acaggcttcc attcggaaat acttctattt ttatttttcc 479041 gcctgatttt tcgttcacca gatcagcgaa tttattggcg gccagccctt ttggcgtatt 479101 ttcagcaacc acgtggctga atttaaacac gatttgatcc tgcaggcctt cctggtcgtc 479161 atcataaaca atctttttat tgccggtatg atcatggaat ccgataaata aagcggttgc 479221 aattccagcg atcatcagtg cgagacatgc aagcaaactc ttcatgaaaa gccctcccct 479281 atgttaagga taatgggggc tatgacattc gtaaagacct gaaaggagaa gctgatgaac 479341 aaaaagaagc tctcaatccg ttggaaaatc acgatcttat cctatatact cgtcattttc 479401 tcctttttga tcggcggcat tgtgctcatc ggcaacattc agcatacaga ggagcgggag 479461 ctgaaaaagc ggctgatgaa tacggcccgg acggtgtcag agatgacaga agtgaaagaa 479521 gccttggcgc gaaaaaaaca aacagaagcg gttcgccatg cggttgaaga aatcaggatg 479581 attaatgaag cagactatat tgtcgtcatg gatatgaatc acatccgata tacgcatcct 479641 gtcagcacaa gcattggcaa gaaatcagaa ggtgcagacg aggaggcagc ttttgcggag 479701 cacatttatt tctctgaagc aaagggcgag atcggcacgg cggttcgcgc tttttatccg 479761 gtaaaggatc aagacctgaa ccaaataggc gtggtgcttg tcggaaaaac gctgccgggg 479821 atcgctgaca tcctgcttca tttaaagcgt gatatcgcct tcatcgttgt gctgacactc 479881 ggctttggcc ttgctggttc ctttttgctg gcccgccata tcaaaaaaca aatgtttcag 479941 cttgaacccc atgagattgt ccgaatgtat gaagaacgga cagcgacgtt tcactcgatg 480001 aatgaagggg tgatcgctat tgacaatcgt ctcgtcatta cgatcttcaa tgaaaaagcg 480061 aaacagatct ttgaagtgca gggggatcta atcggcaagg tgatttggga ggttctcaag 480121 gattcgcgcc tgcccgaaat cgtggagcgg aacaaagcgg tttataatga agaaattcgt 480181 gtcagcggta aggtgatcat gagcagcaga attccgatcg tcatgaagaa aaaagtgatc 480241 ggcgccgttg cgatttttca ggacagaacg gaagcggcca agatggcaga ggaattgact 480301 ggtgtcagaa actttgtgga ggcgctccgt gtccaaaacc atgagcatat gaataagctg 480361 cacacgatcg ccggtctcat ccagctgggg aaatctgaaa aagccttgca gcttgcattc 480421 caggcgtcaa ctgagcagga aaatgtgact gaatttctgc accgctcgat tcaaaatgac 480481 gctgcggcag gccttctatt aagtaaaatc agaaggggaa gagagctcgg cattgctgtt 480541 catatagatg aaaacagcag tcttcagcaa tttcccgagc atgttgatca gcatgatatt 480601 gtcgtgcttt tggggaatct gattgaaaat gccttcggct catttgaaac cgttcaatct 480661 gaagacaaac gaattgacat tagtatcgaa caaacagatg atatccttgc tattttaata 480721 gaagataacg gctgcggaat tgaaccgaca catatgcctc gcctttatga caaaggtttt 480781 acggtcaata aaactggcgg cacaggctat ggcctgtatc tagtgaaaca aatcatagac 480841 aaaggatcgg gcacgataga agttgattca catgcggggc aggggacatc tttttctatc 480901 gtttttccaa tgaaggggga ggaagcacag catggctcgt aaagaatgga aggttctgct 480961 cattgaagac gatccgatgg ttcaagaggt caataaggat ttcattacaa ctgttaaagg 481021 cgttactgtc tgtgcaacgg caggaaacgg agaggaaggc atgaagctga ttaaagaaga 481081 acagccagat ctcgtcattc tcgatgtgta catgccgaaa aaagacggca tcaagacctt 481141 gcaggagatc agaaagcaaa agcttgaagt ggatgtcatt gtcgtctccg ctgcaaaaga 481201 caaggaaacg atctcactca tgctgcaaaa cggggcggtt gactatatct taaagccgtt 481261 taagcttgag cgaatgagac aggcactcga aaagtacaag caatataaac aaaaaatcga 481321 agcgaatgat acgctgtccc aggaacagct cgatgcgatc ctgaatattc cgcagcaggc 481381 cgtacaggat ctgccgaaag ggttgaatca cttcacgatg aatgaagtca ctgctttttt 481441 gaaacagcaa accgcatccc tttctgctga agaggttgcc aaggcgctcg gcatcgccag 481501 agtgacagcc agacgatatc ttgattactt agaaaaaacc gggatcatca aattggacgt 481561 tcaatacggc ggagtcggcc ggccggtcaa ccgctacgtg ttaaaaggat aaacctgaga 481621 ccaaaaagac caaaatgtcc gttatgatca taaacttccc cagactgtat gaaaacgcta 481681 tcattctagt aagaaagaca caaaaggcga ataggacagg gggatgaagg atatgaaact 481741 gtttaaaaat ttaacagttc aggtcataac cgcggtcatc atcggggtca ttgtcgggct 481801 ggtctggccg gatgtcggca aagaaatgaa accgcttggt gatacattta tcaacgctgt 481861 taaaatggtg atcgcaccaa tcattttctt cacaatcgtt ctcgggattg caaaaatggg 481921 cgatatgaag aaggttggaa aagtaggggg aaaagcgttt atctatttcg aggttgtcac 481981 caccctcgca ctcattatcg gtttatttgt cgtcaatatt atgaagccgg gtgcgggtct 482041 tgattacagc aagcttgaaa aaggagatgt atcacaatac acgcaaaatg gcggtcaggg 482101 aatcgactgg attgaattta ttacacacat tgttccgtcc aacatggttg atgccttcgc 482161 aaaaggggac attttgcagg tcttattctt ttctattctt ttcggagtgg gtcttgcggc 482221 attaggcgaa aaaggaaaaa gcgtcattga tttcttcgac aaggtttctc acgttttttt 482281 caaaattatc ggctacatta tgcgtgccgc gccaatcggg gcattcgggg cgatggcgta 482341 tacaatcgga cacttcgggc tcgattccat caaaccgctg gcaagcttaa tgatgtctgt 482401 ttatattacg atgttcctgt tcgtatttgt tgctttaaat atcatctgca agctttacgg 482461 attcagcctg tggaattacc ttcgcttcat taaggatgag cttttgatcg tgcttggcac 482521 aagctcttcc gaatcggtgc ttccgcgtat gatggataaa atggagcgct acggctgttc 482581 caaatccgtt gtcgggcttg ttattccgac gggctattcg tttaacctcg acggcacatc 482641 catctattta tcaatggcga ctgtcttttt ggcacaggtg tttggagtag acctcagcat 482701 cggccagcaa attacgatta tcctcgttct gatgctgaca tcgaagggag cggcaggtgt 482761 gacgggaagc ggatttatcg tccttgcctc aacgctgtca gcgctgcagg tcattccgct 482821 ggaggggctt gcactcctgc tcggggtcga ccgtttcatg agtgaaggaa gagccattgt 482881 gaacctgatc ggaaacggaa tcgccacgat cattgttgcc aaaagcgaaa atgaatttga 482941 tgaagcaaaa agcatagagg ctgttgaagg catgaaaaaa atgaaaacag cagtctgaaa 483001 aaagaacggc ccatccatgg gccgtttttt taattgttta agaattatta aggtaaggac 483061 agagacctca gcattttttt gttatataat ttacaaatgg atactatatt gaatgaagga 483121 cgtttgtcct aacaggagtg tataaatggc cgctttagtt aaattttttc agcacccggg 483181 agtaaggcgt ttctccatct ttgtcgtgtt aactggtgtg ttatatctat ttaagagcat 483241 gatcaactta atattgctta ccttcatttt cacatttcta atggatcgtt tggagcttgt 483301 cgtgcggcag tttgtaagcc agttcttccg cgtgagccag cgggttgtca ttacgtttct 483361 ttacatgttg ctggctgtgc tgcttacagt cgggggcttt gtgttttatc cggtcgtcgc 483421 ggcgcagatc cagcagctgg taaagcagat taaacatatt gcgtatcatc ctgacagcat 483481 ccctttcttt gatgagatca ccagtgtctt cggagatatt aacatcagtt catatgtcaa 483541 agagggcttc aatgtagtgt atacgtatct ggccgatatc agcacattcg gcttgcaggt 483601 cgtgatggcg ctcattctta gcatgttttt cttatttgag aaaaaacggc tttctgaatt 483661 catggcgaaa tttaaaacga gcaaacttag ggtcttttat gaggagattg cttttttcgg 483721 aagcaaattt gcaagaacgt tcggcaaggt gctcgaggct caatttatca ttgcgctcgt 483781 caactgtatt ctgacgttta tcgcgctttg gattatgcat tttccgcagc tgtttgggct 483841 ttcgattatg gtgttcttcc ttggattgat ccctgtagca ggcgtcgtca tttccctgat 483901 tccgctcagc attatcgcct acagcactgg cggtggaatg tatgtgctct acattgtcct 483961 tgtcatattc gccattcatg cgatcgaaac ctatttctta aatccgaagc tgatgtcggc 484021 gaaaacagag ctgccaatct ttttcacctt cacagtactc attttctctg aacacttctt 484081 cggcatttgg ggtttaatta tcgggattcc gatctttgtg tttctccttg atattctgga 484141 tgtcaccaac aaggaagata ggtctaaagg accccgagag aatagcgata aaaagtagtt 484201 taaaatcgaa taatgagtgt gcctcgatct gccggcctgc ctgttcaggg catggaatta 484261 agactcggaa tcggagcttg gcattgcctt gcacagtggt gaacacaaca ggtgacaatg 484321 cttgtcatca gtacggaaac tgaaaagaac aaacagtcgg agcaaacgct catcatcggt 484381 ttaaccaaac atttggaagc aacaaatgct ataatacaaa cagtgcctaa tgttgggcac 484441 tgtttatttt ttgtcgaaaa aggaggaagg ctttatggct gagccgattt tacatattga 484501 aggcctcgat aaaaaaattg ggtctaaaca gattttaaaa cagatcagca tggacgtcat 484561 ggagggtgaa atcatcggcc ttctcggtcc gaatggttcc ggaaaaacaa cactcatccg 484621 tatcatcgtc gggctgttga aacaaaacag cggaagcgtg acaatcagcg gattccagca 484681 tgatacagag tttgaaaaag cgatggaagc ggttggagcg attgttgaga accctgagtt 484741 ctatccgtac ctgacaggct gggaaaacct caagcacttt gcgaatatgc acaaaaaaat 484801 agcggatgaa cggcttgatg aagtggtgga acgtgtcggg ctgacgtcag cgattcatga 484861 taaggtgaaa acctattccc ttgggatgcg ccagcgtctg ggaatcgccc aggcaattct 484921 tcaccggccg aagcttctca ttctagatga accgacaaac ggcctcgatc ctgcggggat 484981 gaaggatttt cgggatcata ttaaggaact cgcagaaatg gaaggaacag ctgtcctgtt 485041 cgccactcat ttattgcgcg aggttgaaga cttgtgcgac cgtgtcatca tcattcaaaa 485101 aggtgagatc aaagcggaag tcagcttaca aggaaccgat caaaccacag aaaaagcgat 485161 tatagaagtg cagccgcaag aaaaagcgct caattggctg acaggcaatc aatatcaagc 485221 tgagagccaa gacgggacga ttgtagttga ggtggcaaaa gaaaacatac cggagctgaa 485281 ccgatcactt gtcggacaag atctgaatgt attttccatt acgccttaca cgcagtcact 485341 ggaagacgaa tttataaaag cgacaacagc tcatcaagag gagggagaag agcttgtcta 485401 aattaatttg gaatgaacat atgaaacttt ttaatcggaa ggtcactttg gtttctctta 485461 tcctgatggc tgtctttcaa ttcttcatgg cattgatcat taaacggatt gtcatcagtg 485521 ccggaacaga tgaaaacttc atcggctatt tatcgtatac accgagcctg aacattttgc 485581 tgcaggcttt aacgatcgta attgcagcaa caattgtttc gatggaattt gataaaaaga 485641 cgatcaaatt tttgctcatt cgtccggtta aacgccaaaa ggtcttttgg tcaaaattaa 485701 tcacagtcgt gatggtcagc ttctatttgt atttggcata ctacattctg gcattattat 485761 tcggtctctt gttttttggc acatcggtga ctgcggaatc aaagacattg ctggtcaaca 485821 ccttggcgct gatcgggtca aactggcttg aagctgtaat gatgggatta ttcgggctgc 485881 tttgttcttc gctgttccgc aatagcgcgg tagcagttgt tgtttctttt gtcgttttat 485941 acggagcgag tacacttgtt cagctcatga agttgtttga aaacaagtgg ggcagctttt 486001 tgctttttgc gaacactgac tttacgcaat acagaagcgg agagacagcg ttgttttcag 486061 gcatgacgcc attgttttca attggaattc tcatcataca tgccatattc ttcatcgttg 486121 ttggctggtg gtgcttctgt aaacgggatg ttcgggtcta aaggcaagga atgacatttt 486181 tgtgaaaaag ctcacgtaaa tcaatatcat ttgatatttt ggtttatact aaaggtactg 486241 acggaggtgt ctcgattgag gaactttatt accgctttac cgatcgtatt gctgcttgga 486301 ttctcatttg tgtcattcat gtttcagttt gaacatcttg tttatttcag gctcgcgctt 486361 gggttgtttt ctctcgtggg actgtacatg atatataaaa tgaagacggg catccgctat 486421 tttatcatct atctgtatgc cagctggatt gtgttggccg cagtgaccgc ttttgaagag 486481 ccgattttct caagcttttt ctttggcggc ctggtgatga cgatgggtta cctgacatat 486541 atgctgattt atctcggcat gaaacaagac cgggatgcaa atcctgtgta atcgcgctgt 486601 tcccttgggg aacggcgtgt ttttctatac tgggcaaaag gttaacagtt gcggaaaaat 486661 ggcaggaaat ctataataca tattaaattt atcggaatta aaactggggg gctgccggat 486721 gtcattattt atacaaaacg atcaacagcg gcaatggatg gagaaaatcg gacggattgc 486781 ggatgaattt cagcaaacag ctgctgaaga tgacgaacag ggacgttttc ctgcagagaa 486841 aatacaaaaa ctgcgtgatg ctgggtatac agcattaaca ttgccggcat ctcatggcgg 486901 agggggcatt tctgtttacg atatgctctt gtttcaagaa cggcttgcac ggggagatgc 486961 tccgacggct cttagcatcg gctggcattt gagcgtgatc ggggagcttg gagaaggcaa 487021 cagctgggat gaagacgtat ttgcatttgt tgccaaggaa gtccaaaacg gagccgtcat 487081 taacagggcg gcgactgaag cgaaaaccgg aagcccgaca agaggagggc gtcccggtac 487141 acacgccgtc aaaaaggatg gcaaatgggc agtgaacggg agaaaaacct ttacgacgat 487201 gtcacaagct ctggattatt ttttagtaac cgcatggatt gaggacaaac aaacaacagg 487261 cgtgtttctc attcataaag atgatcccgg cttgtcgatt gaagaaacgt gggatatgat 487321 ggcgatgcgg gcgactggga gccatgacct tgtactgaac gaagtaatgc ttgatgagaa 487381 taagctggtg gaactgcttc aagggcctcg tggagctaag ccgaatggct ggctgcttca 487441 cattcctgcg atttatcttg gtgtggctca agctgctcgt gactatgcag tgcaatttgc 487501 atctgagtat tctccaaaca gcttgaatgg accgatcaag aatgtcccgg ccgtacagca 487561 aagaacaggc gaaatggagc ttgaactgct caatgccaga cactttcttt tccatatcgc 487621 tcaattgtat gacgatccgg tgcggcgtcc acacttgacc agcgagctcg gtgcggcgaa 487681 acatatcgtc acaaacgctg cgctgtctgt tgttgataaa gcgatgagaa ttgtcggggc 487741 caaaagcctg gaacgaacca acccgcttca gcgctattac cgtgatgtgc gcgccggtct 487801 tcacaacccg ccgatggatg acgccgtgat acacaagctg gcagctgaag cgtttgagtc 487861 ataaaaaaaa gagccttacc ggctcttttt atgtattgtt ttgctcttgc agattttttt 487921 gatgcttgcg gtcgatcctg tcataaataa cgttcatcag ctttggattg cccataatcg 487981 cctctttgtt ttcctggatc agctgttggt aagttttcac tttacgcttc ggcatgctcc 488041 ggcgccctcc tgacatgttt gtattcactt tctaactccg tcagcgacaa ttcatacaga 488101 tgacgctttg actttttgta tataccattc tgtattaaca gatgaatgag ctgttttttt 488161 ctgatttctg cagactgagg tgtcattgtg tcaccaacct ccaatcaaac gatattgata 488221 atcattatca attaacttca gtatacaatg tccgcaatag cctgtaaaga tgaaaagagt 488281 cctattcttg gccaatttac aaacattcaa caaatcgaca aaaagtttcc cgggcaataa 488341 tttgctgtcg aaatattccg cttcattgaa cgcaccctgc tatttttcat gttttgaacc 488401 atactatgta atagaatgga ggctggtatt caatggagcg gacagaaaat ctgaaaaagg 488461 gagaaaaagg ggcgctcctc aatatttttg catatgtcat ccttgctgtt gtaaagctag 488521 ttatcgggat tctatatcat tctgaagcgc tgagagcaga cgggttaaat aatggaacag 488581 atattgttgc gtcagtagca gtgctgatag gattgcggat ttctcaaaga ccggctgaca 488641 gcgatcatcc atacggccat tatcgggctg aaacaatttc gtctcttgtt gcgtctttta 488701 ttatgatggc agtcggcatt gaagtgttaa tcggcggagg aaaagcgatt gcgggcggca 488761 caacggaaac gccaaatctt atcgcggcat ggacggcgtt aggcagtgct gtgtttatgt 488821 atggcatcta tttatataac aaaaggctgg cagcgtccat taaaagctct gccctgatgg 488881 cagcggcaaa ggacagcagg tcagacgctt ttgtaagtgc cggcgcgttt atcggtgttt 488941 tttcgtccca gctgaagctg ccgtgggttg atccggtaac ggcttttatc atcggcatca 489001 tcatttgcaa aactgcgtgg gatatcttta aagacgcttc acattcctta acagacggct 489061 tccatttaaa agatcttgag ccttacaaac agaccgtcgg caggatcgaa aatgtgcatc 489121 gcctaaagga tgtgaaagcg aggtatttag gcagtacagt tcatatcgag atggtgatta 489181 cggttgatcc gaagcttaca gtagaagaag gccatggagt ggcggatgaa gtagaagaca 489241 aaataaaaca tgaacacgat gtcactcatg ttcatgttca tgtagagcct gacgacataa 489301 aataaggctg tttaacgaat tagcttatat gttcagataa aaattcagtc acttcttcag 489361 gcgttttggc attggcgctg tgaaggtgag ctgttttttc accgttcttg aaaataagca 489421 ggctgggaat gcccattact tggtattttt cagccaggtc aggaagctcg tccttattca 489481 gctcatacca gtcgttttgg ttgtattctt ccaaaatatc gccgatgaac atattcatgc 489541 gtgtgcagtc tgggcaccaa tcagcataaa actttacaat gatttcttta tcagattgaa 489601 tcagttcatt aaattgttcg tttgttgtga tttttttcat atgtcacatc tccttttcaa 489661 tgccatttta atataaaata aaaaggaatt acatacaaat gcattcaaca tcagcatgcc 489721 caaaaataat tagatcattt tccggtgaaa atgataagat agtaaagatg aattgtagtg 489781 gggggagtat ccattgaaaa caagtctagg attagtgtac ggaggaaagt cggcagaaca 489841 taatgtttcc ctgcagacag ctctggctgt aatcaaagcg ctaaatactg agaagtttga 489901 tatacatccg atttatataa cagaaaaagg cgaatgggtt agaggcgccc gtttaactga 489961 acctgtttca aacgtgaaaa tgcttcaatt tgagcaagga ggcagtgctt tttctccagc 490021 tgccctgaac caggagatgt ttccgcagga agcgtcacag caaaatgaag ccatcgacgt 490081 cgtattcccg ctcctccacg gaccgaacgg agaagacggt acgatccagg gaatgctcga 490141 gctgttgaac attccttatg tcggcaacgg agtgcttgct tcctcagctg gcatggataa 490201 agttgtcatg aaacatttat ttgcgcaggt tggccttgct caggctaaat acgcagcttt 490261 ccttaagaaa gactggactc gttctccgaa agaaagctgt gaggaggttg aacaggaatt 490321 aggctaccct tgcttcgtaa aaccggcgaa cctcggctca agtgtcggaa tcagcaaatg 490381 ccgaaaccgt gaagaactgc aaaaagcgtt tgagcttgct ttccaatatg accgcaaagt 490441 cgtcgttgaa gaaggaatta acggccgcga gatcgaaatc ggcgttcttg gaaatgatga 490501 tcctaaatgc tctgttgtgg gagaaatcgc accgaagaca gatttctacg attacaaagc 490561 gaaatatgag gatggagata ctgatctgat gattccggcg attgtgactg atgaggaata 490621 cgcaacaatc agtgatatgg cgatcaaagc gtttaaagcg atcgacggtt caggactcgt 490681 cagagcggac tttttcctga cagctgacgg cgaagttctg atcaatgaag tcaacacaat 490741 gcctggcttt acacctttca gcatgttccc gttgctctgg aaagaagccg gagtggaata 490801 tgctgacctg attgaacagc ttgtggagct tgcaaaagaa cgccacgctg aaaaacaatt 490861 gattaagcat acattctaat gaagaaggac actgccggta aaagggcagt gttttttccc 490921 gtatatacaa aagaaagaga gggaccttac ttgattaagc gaacagtaaa aaacattgcc 490981 gaaatggtta aaggcacact agcaaatccg caatatgaac aaacagtcat tcatggagtg 491041 gcaaccgata caagaaaact ggaacaacat cagctcttta ttccgctgaa aggggaacgt 491101 tttgacggcc actcttttgt ggagcaggcc tttgaagctg gtgtagcggc tgttctttgg 491161 gatcggtcag taccaaatcc gcccgagaat cacgccgtca ttttagtgga cgataccctt 491221 actgcacttc agcagcttgc aaaagcttat ttgcaggagc ttggcacgcg tgtcatcgga 491281 gtaaccggaa gcaatggcaa aacgacaaca aaagatatga ttcacgccgt attggggacc 491341 cagtaccgtg tccacaaaac tggaggaaac ttcaataatc atatcggttt gccgctgacg 491401 gttttagcga tgcctgaaaa tacggagatc gccgtattgg agatgggaat gagcgccaaa 491461 ggagaaattg acctcttgag ccgactggca aacccggatg cggcagtgat tacgaatatc 491521 ggcgaatcgc atatgcaaga cctcggctct agagagggca tcgcggaggc gaagcttgaa 491581 atcataaacg ggcttaaaga agacggagtg ctgatttata tcggggacga accgcttctt 491641 caaaatgcat acagctgcca gacgaaaacg tacggtacgg gaacgcataa tgattatcag 491701 cttcaggatg tcagccagag tgaggaagga acccatttta caatcaaagg gatagaaaac 491761 acgtttttta ttccaatact cggcaagcac aatgtgatga acgccatggc tgcaattgct 491821 gcaggggctt attttggcat cgcgcctgag gatgcggcaa aaggactgag cggcctaaag 491881 gtaaccggga tgaggcttga actcatcaaa acagacagcg gcctttcgat aatcaatgac 491941 gcttataatg cgagcccgac ttccatgaaa gctgcaattc aattgacaga aagccttgaa 492001 ggctacggca aaaaaatgct cgtgctcggt gatatgcttg aactcggcga tcttgaagaa 492061 acgttccata aagagtgcgg cgctgtgatc agccctgata aaattgaccg cgtctttacg 492121 tacggaaaac tgggagcttt tatcgcggaa ggcgccctga aacactttga gaaagaccgc 492181 gtcagccatt acactgagaa aaaagatctc cttcaagctg tgaaggaaaa cgcatcaaaa 492241 ggcgatttga ttttattcaa agcgtccaga ggtatgaagc ttgaagaaat cgttaaagat 492301 ttaatagaga gcccgctttc ataagaaaat attttgcgaa aaaacgcata ttgcatcata 492361 aaataacctg atatgcaaac actaatgtat gccggccgaa aattatgtat atctggccgg 492421 ctgcggctat gatacaatat atataggtta tttcgcgata cgaacatatt cgtccggact 492481 tttcatcgtg acccgaagtt ctccgctgga ttcttgggag cggatggagc agcagccggc 492541 atattcgaga tgccgatctg cttctcatct tattgaaaaa caaatagtgt aatggtaaga 492601 taaaacttaa agtaattcgg gctttgtata cggatggatc ctgtccttct tgtctaaagg 492661 gcagttttat aagtggtaaa tcacgacatt actgaaacag caattagaag gagtttgaat 492721 aatttgacta taacgtttca agattttaat ttaagttctg atctcatgaa agcaattaat 492781 cgtatgggat ttgaagaagc aacaccgatt caggcacaaa cgataccgct cggactttca 492841 aataaagacg tcattggaca agcgcaaaca ggtacaggta aaacagctgc gtttggtata 492901 ccccttgttg aaaaaattaa ccccgagtct cctaatattc aagcaatcgt aatcgcgcca 492961 acccgtgaat tagccattca agtatctgaa gaattgtata aaatcggaca agataaacgt 493021 gcgaaggttc ttcctattta cggcggacag gatattggac ggcaaatccg ggcgttaaag 493081 aagaatccga atattattgt cggaacacct ggacgtcttc ttgaccacat caaccgccgc 493141 accattcgtt taaacaatgt aaataccgtt gtaatggatg aagcggatga aatgctgaac 493201 atgggattca ttgacgatat tgaatctatc ctttcaaacg tgccaagcga gcatcagaca 493261 cttctgttct ctgccacaat gcctgcgccg atcaaacgca ttgcagagcg cttcatgact 493321 gagccggaac acgtaaaagt aaaagcgaaa gaaatgacgg tttctaacat tcagcagttc 493381 tatttggaag tgcaagaacg taaaaaattc gatacactga ctcgccttct tgatattcag 493441 tctcctgagc ttgcgatcgt attcggacgt acaaaacgcc gtgtcgatga gctggctgaa 493501 gctctgaacc ttcgcggata tgcagctgaa ggtattcacg gtgacttaac gcaggcgaaa 493561 cgtatggttg cgcttcgtaa atttaaagaa ggcgcaatcg aagttctagt cgcaactgat 493621 gttgccgctc gcggacttga tatctcaggt gttacacacg tatacaactt cgacgtgcct 493681 caagatcctg aaagctacgt tcaccgtatc ggaagaacgg gccgtgcagg aaaaacaggt 493741 atggcgatga cgttcattac accgcgtgag aaaagcatgc ttcgcgcaat tgaacaaaca 493801 acaaaacgca aaatggaccg catgaaggag cctacacttg atgaagcgtt agaaggtcag 493861 caacaggtta ctgttgaacg tcttcgcaca acaatcagtg aaaacaacct gaacttctac 493921 atgacagcgg cagctgagct gcttgaagat catgatgcag taacagtggt tgcggcggct 493981 atcaaaatgg ctacaaaaga gccagacgac acaccggttc gcttaacaga cgaagcgccg 494041 atggtcagca aacgctacaa gaaccagcgc tcttctaaac gcagagacgg tcaaggcggc 494101 ggctaccgcg gcggaaaagg gaaaagcaac aaccgttctt cctatgacaa aaagcgttca 494161 aacgatcgcc gttcttcagg tgacagacgc cagaaaaaat cttactaatt tgatcgattc 494221 agagcccaaa acatgatgtt ttgggctttt ttatgttcgt gatttgttat tcagcaaact 494281 ttcagctgac ggaagccatt tttctctgta tgcttaagaa tgaaaccttt ctgtaaaaga 494341 gacgtataaa taacgacgaa aaaaagggag gtaggtattt ttgagagagc agccaaaaaa 494401 ccaaatcagt ccagacggat taaaggtttg gcgacttcaa gagatcatca tatccgctgt 494461 ttgcttgctt attgtcattg cagttgcagt gttaagctat tattttcatt ggccgtactg 494521 gatcagcggc gtgctcggcg ctgtttggct gctgggatcg attgtgacgg tctttatcat 494581 tccgaaggtc cgtcataagg tgtggcgata tgaagtccat gaacatgaaa tagatattca 494641 gtcaggtatt tttgtggtga cacgtgtgat tgttccgatg gtcagagttc agcacgtcga 494701 tacgtcacaa gggccattat taaaaaaata caacctggca acggtgaaaa tttccacagc 494761 cgcgaccgtt cattcgatcc ccgctttaga gatggaggaa gcggatcggc taagagactc 494821 catttcccgt ctggcgaggg tgactgacga tgatgtctga accgaaacgc ctgcacccgg 494881 tggcagtcat tttgaattta tgccatacca ttattcaaac gataaaaaat atcattctgc 494941 cattcttttt tgtgtatatt gtcaattcaa accatactgt ccgtttttac ggagccattg 495001 cgctcggtgt gctgttcatc tggcttgtag cggcaagcat tatcaaatgg agaaggttta 495061 cctatcgaat tgaagatgat gaatttagaa ttgaagaagg cttatttgtt acgaaaaaac 495121 gatacatatc gattgatcgg attcaaacaa tgaatacgag cgcgggcctt gtccagcaaa 495181 tctttaagct tgtgaagctg caaattgaaa cagcaggcgg aggcaaggag gcagaagccg 495241 ttctttctgc tatttctgtt gaagaagcgg aacgcatcaa agaagctgtc tttaagaaaa 495301 aagcgcaaag acgagaaaat gaacttgatg aagaacggct tgaagctgaa gaggagttgg 495361 atccgtccgt tgaggtgcaa gagcactatc gcatgaacgc gaaagaattg ctcatggccg 495421 cttctacctc cggcggaatc ggagtcatta tctccgctgt atttgcactt atttcccagc 495481 ttgatgaagt gctgccgatg gattggttat tcgataaatt ttccttcctt cagcacgcca 495541 gcatcggtat ttatgcggta ctcattttta tcggtttatt tatcgcctgg attttcagca 495601 tcgcgggcat gatgtttaga tacgcgaact ttcaaatcat aaaaaaagag caggaactgg 495661 tgatttcaag gggaattatt gaaaaacatc aagtcacgat tccgctgcga aaaatacaag 495721 ccattaaaat caaagaaaat atcattcgcc agcttttcgg ctttgtaacg gtgtccatcg 495781 tcagcgcagg aggcggcgac cgggaaaaag aagaaggcgc tttgaccatt ctctttccaa 495841 tgattcataa aaaaaagctt ccgcacatgc tccgaacatt tacgccggaa tacacgctgg 495901 aagaaaactg ccgccgcctg ccgcggcgcg cgttgaaacg ctatttgttc cgttctgtca 495961 ttttttcact ctttttgatc atcccgttat gtatcttctt tcagccatgg ggctatctgt 496021 cagtgatcct gctgccgata gaattgctct tcggctatct cgcgtataaa gaggctgcat 496081 ggacgatcaa cggggaccgt cttcagctga cgtctagatt tataggcaga acaaccgcca 496141 ttgtactgaa aaaacgaatg caggtctgca agttcagcca atcctatttc caaaagaaag 496201 gccgcttgta taccatttct acttcggtga aatcatcgag ccatatggaa gagttaacgg 496261 tgagggacgt aggtgaagag gatgcagcct tcattttaaa gtggtactca tatgaaaaag 496321 cggacggtta ataccgccgc tccagcgtgt cggcaaaccc tcgcattcgt tgtcaggact 496381 gcgcttcggt gctcaatgcg aagtggatca acggctaaat tctcaggcgt cctgcctaaa 496441 cgccgtcgtc atcacatcct gtgaaagtcc gctcctatgc tcgtccttcc tagacttcat 496501 gggttttcaa tcacgctgaa aagatgacaa aatcctaaaa tgaaaaccat tttaggattt 496561 tgtcaacaat ctgaagcggc ggttaatacc gccgctcttt tttttgcacg cataaaaacg 496621 aaagaagaaa cccgccgcat agtccaaaca aatgggccat catgttaata ttggagttga 496681 taaacgacat gagaacggca aatgcgagca gtgtgatgat cattttggaa tgctcctgcc 496741 caattaactc attgcgaaaa agaaccataa acaggtatac gccaaatagc ccgaaaatgg 496801 cgcctgaagc cccgacatgc acgtaatcaa gcggctctgt aacataagtg ccgatattgc 496861 cgatgatgcc ggagccggcg tatacaagaa ggaaacgcgc ttttcccagc atgcgttcca 496921 aagccggggc aaataaaaag atggacatgg aattaaacag cagatgtgtg aaaccggcgt 496981 gcagcaaaat cggtgtgata agccgccacc attcaccgtt tgcgacacct agattatagc 497041 ctgtgacggt atccctccat aacacgactg aatgggcagg aagtgaaaaa aacagccaga 497101 gaacagcttg caaagccaat ataaaggtga caacggggta aagcctgata aatgtttgaa 497161 aattttcagt ccgtataaac attccgagcc ccttttcttc attttggtat atctatagta 497221 acacgtttat gagacaaacc atttaaatag tacgtacgca aaggaggtta tcatacatga 497281 tttacggcat tgggctggac attaccgagc ttaaacggat cgcctctatg gctgggcgcc 497341 agaaaaggtt tgccgagcgg attttgacgc gaagcgagct tgaccaatac tatgagcttt 497401 cagagaaaag aaaaaacgaa tttctcgcgg gcagattcgc ggcaaaagaa gcgttctcga 497461 aagcatttgg caccggcatt gggaggcagc tcagctttca ggacattgaa attaggaaag 497521 accaaaatgg caagccctat atcatttgta cgaaactgag ccaggccgcc gttcacgtat 497581 cgatcactca tacaaaagaa tacgctgccg cgcaggttgt gattgaaagg ttgtcaagct 497641 agtctgcata ttagggaaac cccactcata tatttgatag tgcattaagg gagacaagtt 497701 gtttgaggct tttatggtac gcatctgttc tgcctaaacg tgtaccgagc gtaccgttaa 497761 agtcaaacaa gcgatttctt ccttttacat caattgagaa aaaggggttg aaaaaggtga 497821 gaaaaagctt tgttttgctt ttaacgggac tgcttgctgt tcttattctt tctgcctgcg 497881 ggcaaaaaac acagcaagat attgtggccg ggttagatga aaaggcgaaa gaatacacct 497941 cgtacaaagc aaaagcgaaa atgaccatcg agacagggag tgagcctcaa gtatacaatg 498001 tggaaatctg gcacaaaaag ccgtctctgt acagggttta tttagaaaat ccgaaaaagg 498061 accaaaacca agtcatttta cgaaatgaaa acggagtatt cgttctcacg ccgtctttaa 498121 ataagagctt cagatttcaa agcgattggc cgaacaacag cagccaggtt tatctgtttg 498181 aatcgctcgt aaaggatgtt caaaacgatt cggatgcagt tttcacagcg aaagaaaaga 498241 aatacgtatt tgaaacaaaa acaaactatc agcataacaa aatgctgccc acgcaagaaa 498301 tcacatttaa caaaaaagat atgagcccgt catctgtcaa agtgatggat actgaccgga 498361 aagtgatggt caaagtagaa ttcagcagct ttgaatttaa taaacaattt gataaagaat 498421 catttgatga aaagaaaaat atgacccttt ctcaaatgga tgtcgccaca agcgcaaagc 498481 cttccgatac atttgcggtc aaaacgccgc tggaactgcc gcttggcgtc aagctgcttg 498541 aagaaaaaga tatatctact gaagacggga agcgcatcat catgacgtac ggaggagaaa 498601 aatcatttac gttaattcag gaaaaagccc agattgccaa ggcttcctcc tccgttacgc 498661 tgaacggcga accggtaaat ctcggctaca ccatcggcgc cctgtcggat gcatcattat 498721 catggacata tgacggcgta gattaccttc tctcttctaa agatctttct aaagaggaaa 498781 tggtgacagt agcgaaaagc atgcagggac aatcatcgaa ataaccgcca aaggccaaac 498841 atgatttggc ctttttttcg ttagacatcg tttcccttta gcctttaatt ttagtatgat 498901 atgtaaatga tattgaataa aagctaggaa gtgtcgtaat gagcacaaaa cctttttaca 498961 gagatacgtg ggcggaaatt gacttgtccg cgataaagga aaatgtcagc aatatgaaaa 499021 aacatatcgg tgaacatgtc cacttgatgg cagttgtgaa agcaaacgcc tacgggcatg 499081 gtgatgcaga aacagcaaag gctgctcttg acgcaggtgc ttcatgcttg gccgtggcca 499141 ttttggatga agcgatttca ctgcgcaaaa agggattgaa ggcgcctata ttggtgcttg 499201 gcgcggttcc cccggagtat gtggcaatcg ctgctgagta tgacgtgacc ttaacaggtt 499261 attctgttga atggcttcag gaggcagccc gccacacgaa aaaaggttct cttcattttc 499321 atctgaaggt cgatacgggg atgaacagac ttggtgtaaa aacagaggaa gaagttcaga 499381 acgtgatggc aattcttgac cgcaaccctc gtttaaagtg caaaggggta tttacccatt 499441 ttgcgacagc ggatgaaaaa gaaagaggct atttcttaat gcagtttgag cgctttaaag 499501 agctgattgc tccgctgccg ttaaagaatc taatggtcca ctgcgcgaac agcgccgctg 499561 gactccggct gaaaaaaggc ttttttaatg cagtcagatt cggcatcggc atgtatggcc 499621 ttcgcccgtc tgctgacatg tcggacgaga taccgtttca gctgcgtccg gcatttaccc 499681 tgcattcgac actgtcacat gtcaaactga tcagaaaagg cgagagcgtc agctacggag 499741 ccgagtacac agcggaaaaa gacacatgga tcgggacggt gcctgtaggc tatgcggacg 499801 gctggctccg aaaattgaaa gggaccgaca tccttgtgaa gggaaaacgc ctgaaaattg 499861 ccggccgaat ttgcatggac caatttatgg tggagctgga tcaggaatat ccgccgggca 499921 caaaagtcac attaataggc cggcaggggg atgaatatat ttccatggat gagattgcag 499981 gaaggctcga aaccattaac tatgaggtgg cctgtacaat aagttcccgt gttccccgta 500041 tgtttttgga aaatgggagt ataatggaag taagaaatcc tttattgcag gtaaatataa 500101 gcaattaact tacctaaatg gagaattcat aaaacagctt tgcttgaaga gtgaataatg 500161 gtatcattat cactggatgg ataaaagagt cgtatccgta agtttggtgg aggtgtatgt 500221 tttttgtctg aatccagcgc aagaaccgaa atgaaaatca gcttgcccga aaacctagta 500281 gctgaattgg atggtgtagc gatgcgggag aaacgaagca gaaacgaact gatatcacaa 500341 gcagtgagag cgtatgtcag cgaacgaaca actcgtcaca accgtgattt gatgagacgc 500401 ggctatatgg aaatggcgaa aatcaacctg aatatttctt ctgaggctca ctttgcggag 500461 tgcgaggctg aaacgacagt tgagcgctta gtcagcggag gataatcatt tgattgtgaa 500521 acgcggcgat gtttattttg ctgatttatc tcctgttgtt ggctcagagc aaggcggggt 500581 gcgcccggtt ttagtgatcc aaaatgacat cggaaatcgc ttcagcccaa ctgctattgt 500641 tgcagccata acagcacaaa tacagaaagc gaaattacca acccacgtcg aaatcgatgc 500701 aaaacgctac ggttttgaaa gagattccgt tattttgctg gagcaaattc ggacgattga 500761 caagcaaagg ttaacggata agattactca tctggatgat gaaatgatgg ataaggttga 500821 tgaagcctta caaatcagtt tggcactcat tgatttttag acatatttgc aggttgctca 500881 aatagagcaa ctttttttgt tttcaaaaaa cataaacgat ataatagtga aataacgaaa 500941 aaatatgttg ttttttattg ggaggtaagc gaatttgatg tcgaaccaga ctgtatacca 501001 gttcattgcc gaaaatcaaa atgaactgct ccaactgtgg actgacacac taaaagaatt 501061 aagcgagcaa gaatcctatc agctgactga ccaagtgtat gaaaatatat ctaaagaata 501121 tatcgacatt ctgctgctgt ctgttaagga cgaaaatgct gctgaaagcc aaatcagcga 501181 actggcgctt cgagcggtcc aaatcggact gtctatgaag tttttggcta ctgcacttgc 501241 cgaattctgg aagcgtctct acacgaaaat gaatgataag agattgccag atcaagagag 501301 cacggaatta atctggcaga ttgatcgctt tttcagcccg attaacacag aaatttttaa 501361 tcaatactca atctcatggg aaaaaacagt atccctgcaa aaaatcgcgc tgcaagagct 501421 gtctgcgccg cttatcccgg tgtttgaaaa tatcactgtg atgcctcttg tcggaacaat 501481 tgataccgaa cgcgcgaaac gaattatgga aaaccttctt aatggcgtcg tcaaacaccg 501541 ttcccaagtc gtgctgattg acattacagg tgtccctgtc gtcgatacga tggttgccca 501601 tcatattatt caggcatcag aagctgtaag gcttgtcgga gcaaaatgcc tgctggccgg 501661 aatccgtccg gaaattgctc aaacaatcgt caacctgggg attgatttat cccaagttat 501721 aactaagaat accctgcaaa aaggaattca aacagcattg gaaatgacgg atcgaaaaat 501781 cgtttcattg ggggaataac attttgagac atccgaaaat cccgatcttg aaactgtata 501841 attgcttatt agtgtccatt cagtgggaac ttgatgacca gacagcatta acttttcaag 501901 aagacttatt aaataaaata tacgaaacag gtgctaacgg agtcgtcatt gacctgacat 501961 ctgtggatat gattgattca tttatcgcga aagtgctggg ggacgtcatt acaatgtcta 502021 agttaatggg ggctaaagtc gtcttgaccg gcattcagcc cgctgtggca gtgacgctga 502081 ttgaacttgg aatcgcgctt gaggaaatcg aaactgcgct cgacttagag caggggcttg 502141 agacattgaa gcgggaattg ggggaatagc gaatgaacga ccaatcctgt gtaagaatca 502201 tgacagaatg ggatattgtg gccgccagac agctgggacg aaacgttgcg aaagaactgg 502261 gtttcggcac ggtagaccag gctagaatta caacggctat ttcagaatta gccaggaata 502321 tttatttata tgccggcaaa gggcagattg gaattgaaca ggtcgcagac agaggaaaaa 502381 aaggcctgaa aatcatagcg gaagaccaag ggccgggaat tcctgatatc cgaaaagtca 502441 tggaagacgg gttttcaacg tctggaggac ttggtgcggg acttcccggg gtcaaaaggc 502501 tgatggatga attcagctta aattccgtag cgggggaagg aacagagata caagccatca 502561 aatggcttcg gtaggaggta agaacgtgga ttttagggag gttattgagc agcggtatca 502621 tcagctgctt agtcgatata tagccgaatt aacagaaaca tctttatatc aagcccaaaa 502681 attcagccga aaaacaatcg agcaccaaat tcctccggaa gaaatcatca gcattcacag 502741 aaaagtgctg aaggagctgt atccaagtct cccggaagat gtgtttcatt cgctggattt 502801 tttaatagaa gtcatgattg gctatggaat ggcttatcag gagcatcaaa cccttagagg 502861 gatacagcag gaaatcaaat cagaaattga aatcgcggca aatgtccagc agacgcttct 502921 cggaactaaa gttcctcagg aggaagcgct ggatatcggc gccatcagtg ttcccgctaa 502981 acagatgagc ggtgattact accactttgt caaagacaag gaatccatca atatcgcaat 503041 cgcggacgtg atcggaaaag gcattccagc ggctttatgc atgtccatga ttaaatacgc 503101 aatggactct ttgccggaaa cgggcataca cccttctcaa gtgctgaaaa atttgaatcg 503161 tgttgttgaa caaaacgttg atgccagtat gtttattacg atgttttatg cgaattacaa 503221 tatggacaag catcaattta catatgcttc agcgggacat gaaccgggat tctattattc 503281 tcaaaaagac aacacgtttt acgatttaga ggccaaagga ctcgttctcg gcatctcgca 503341 ggactatgac tacaaacaat tcgatcagca tctggaaaag ggcgatatga ttgttttatt 503401 ttctgacggc gtcacagaat gcagaacgga aaacggtttc ttggagcgtc ctgatctgca 503461 gaagctcatt gaggaacata tgtgttcctc tgcgcaggaa atggtcaaaa acatttatga 503521 cagcctcctc aaattgcagg attttcagct tcacgatgat tttacgttaa ttgttttgcg 503581 gagaaaggtt taacgtctgt cagacgaggg tataaagcaa ctagtgattt gaaggaaaat 503641 ttgaggtgat acgaatgaat ataaatgttg atgtgaagca aaacgagaat gatatacaag 503701 taaacattgc aggagaaatt gatgtatact cagccccggt gcttagagag aagctcgttc 503761 ctctggcaga acaaggagct gacttaagaa tttgcctgaa agatgtcagc tacatggaca 503821 gtaccggatt gggcgttttt gtagggacct ttaaaatggt gaaaaaacaa ggtggttcgc 503881 tgaaacttga aaatctttct gaacggctga tccgactgtt tgacattaca ggcttgaagg 503941 acatcattga tatttctgca aagtcagaag gtggagtgca atgaagaata atgctgatta 504001 catcgaaatg aaagtgccgg cccaacctga atatgtggga attataagac tgacgctgtc 504061 aggggtcgca agcagaatgg gctatacgta cgatgaaatt gaagacttga aaatcgcagt 504121 cagtgaggcg tgcacaaatg cggttcagca cgcttacaaa gaagataaaa atggggaagt 504181 gtcaatacga ttcggtgtgt ttgaagaccg tttagaggtt attgtggcgg atgaaggaga 504241 cagctttgac tttgatcaaa agcagcagga tctagggccg tacacacctt cgcacacagt 504301 tgatcaatta tcagaaggag ggctcggtct atatttaatg gaaacgctca tggatgaagt 504361 cagagtgcaa aaccactccg gcgtcaccgt agcgatgaca aagtatttaa atggggagcg 504421 agttgatcat gacacaacca tcaaaaacta cgaaactaac taaagatgaa gtcgatcggc 504481 tcataagcga ttaccaaaca aagcaagatg aacaagcgca ggaaacgctt gtgcgggtgt 504541 atacaaatct ggttgacatg cttgcgaaaa aatactcaaa aggcaaaagc ttccacgagg 504601 atctccgcca ggtcggcatg atcgggctgc taggcgcgat taagcgatac gatcctgttg 504661 tcggcaaatc gtttgaagct tttgcaatcc cgacaatcat cggtgaaatt aaacgtttcc 504721 tcagagataa aacatggagc gttcatgtgc cgagacgaat taaagaactc ggtccaagaa 504781 tcaaaatggc ggttgatcag ctgaccactg aaacacaaag atcgccgaaa gtcgaagaga 504841 ttgccgaatt cctcgatgtt tctgaagaag aggttcttga aacgatggaa atgggcaaaa 504901 gctatcaagc cttatccgtt gaccacagca ttgaagcgga ttcggacgga agcactgtca 504961 cgattcttga tatcgtcgga tcacaggagg acggatatga gcgggtcaac cagcaattga 505021 tgctgcaaag cgtgcttcat gtcctttcag accgtgagaa acaaatcata gaccttacgt 505081 atattcaaaa caaaagccaa aaagaaactg gggacattct cggtatatct caaatgcacg 505141 tctcgcgctt gcaacgcaaa gctgtgaaga agctcagaga ggccttgatt gaagatccct 505201 cgatggagtt aatgtaatga tccaggttga agaaaacgag catattcaaa ctctagtata 505261 tcaactgaat aaagaaggga aatcgatttg cggtgacagt ttttttatga aagctgatga 505321 taaggagtta atttgcgcgg ttgctgacgg actgggaagt ggatcacttg ctaacgaatc 505381 ctctgcagcc atcaaagact tagtggaaaa ctatgcgagt gaagacgtag aaagcattat 505441 cgaacgctgt aatcaggcga tgaaaaacaa aagaggcgct acagcatcta tcctgaaaat 505501 caattttgag caaaggcagt ttacgtactg ctctgtcgga aatgtacggt ttattctgca 505561 ttccccgtct ggtgaaagct tttatcctct gccgatttcg ggctatttat caggcaagcc 505621 gcaaaaatac aaaacgcaca ccgccaccta tgaaaagggt tcaaagttca ttatacatac 505681 agatggactc aacgtacctg atatccgctc ccatttgaaa aaaggccaat cggtagaaga 505741 aatatcgaat tcgctgaaaa tgtatacgac atcgagaaaa gatgacctga cctatattct 505801 cggacagctg tcctaaaaaa ccagaaaaag aagctggaca tccggcttct tttttttgcg 505861 gttgactatt aataagtgcg cttattatac ttaataagtg aacttatcat tctgggagct 505921 tatgggatgt ggaattatga atacacagcg atagctgatg tggatgtggg aaaacctgga 505981 actgttatca ggaaacagaa acaatggatc aatgggagac gggtattgca tcagattctt 506041 tgaaaggaca atttcaaaat ggaacggaag gaacattgct tctgcaagga aaaacaattc 506101 tcttatggct tgagcatgtg gagaaacatc gggcgttttc tgtcatggtc aacatgcccg 506161 catagcaatg taataatgga gttttttcac gtgcttcaaa agcaaaaaga agatttgtgt 506221 atcacatatg gaattgtatt agaaggcgct gaagcaaaaa agtggggaga aatcattggg 506281 actgaactgt ctaaagacat gccgacggct gtcagcaggc ttgtccatct ttacggagga 506341 gtgataaaat gaacacaaat tactggatcg gcgttgtgtc agagcaacat gtattaaaag 506401 gcgctgccgg cggttttgca cagctgtgcc atggaaaaaa agccccgctc gccaaaatga 506461 aagagggaga ttggctgatt tattattctc cgagagacgc atatccagac ggcaaactgc 506521 tgcgaagctt tactgcgatc ggcaaagtaa aaagcggaaa catctatccg tatcaaatgg 506581 ctccgaattt tattccatac cgattagata tagactatta tccatgccat aaaatcggtt 506641 tttacgacat taaatcaaag cttgaatttg ttcaggaaac caagcatctt ggctttttat 506701 ttcgcagagg acactttgaa ataagcaaaa aagatttttt gacaatagca caagcgatgg 506761 gagttaacat aagtggaatg gcactctaaa tttagcggtc cgaacacaag cccgggcttt 506821 ttattatggc aggccacgca aagttggcag cggaaagtag gaaaagcatt ggctgagttt 506881 gacctgaccc acgttcaatt tgttctgctg acctcgtgca agtatatgat tgctcacgga 506941 gaaaccgtca cgcaaaaaaa acttgcaagc ttcagccaga ccaatatcat gatggtttcg 507001 gaggttgtgc ggacgcttga gaaaaaagga tttatcgaaa gaagcaaaaa tccccaggat 507061 aaaagagagg tcctcctgtc tcttacagaa ataggaggag aaaaagtaac agcggctttg 507121 ccaattgttg agaagattga tcaagccttc tttgcagctg cgatgaaaaa agagaatttt 507181 ctgagcggct tacaggaact attgaaacat gagtaaagat acgggcagcg ccagctgtct 507241 ttttttatgt gtttttttcg gtttttgata cactagagaa agaacgacaa aattggaggc 507301 tttggttaca tggaaacgtc agccctttta aaacagcaaa ttgcgaaaga aataggttta 507361 tcacaaaaac acgttgaaag tgtcatccgc ctgcttgagg acggcaatac agtcccgttt 507421 attgcccggt atcgaaaaga gcagacgggt tcaatggatg aggttcagat tcagacgatt 507481 tctgaacgct ggcaatacat acaaaacctg aatcagcgaa aagaagaagt catcaggctg 507541 attgcagagc aggataaact gacagataat ctaaaacgta aaatcgagca atcggtgaag 507601 cttcaggaag tggaagacct ttaccgccct tataaacaaa aacgtaaaac aaaggcgaca 507661 gtcgccaaaa gcaaaggcct tgagccgctt gccgactata tcctgacact tccccaagat 507721 gatcatctgg cagcaactgc agaccaatac atcagcgaag aaaaagaagt gttcacacga 507781 gaagaagcga ttgaaggcgc caagcacatt attgcggaac aaatctcaga cgagccgacc 507841 ttcagaaagt ggattcgcca ggaaaccttc aaaagaggaa ccattaagtc tgcagccgga 507901 aagtcggcag acaccgatga gaaaaatgtg tatgaaatgt attacgagta tgaagagcca 507961 attgcaaaag ttgttccgca tagggtgctg gcaatgaacc gcggcgaaaa agaagacatt 508021 ttaaaggtag cgatcgaacc gcctgcggat cacattaagg cgtatttaga aaaacaaatc 508081 atcaaaaatc gctcaacatc cgtaagagag attttgcagg agacaattga agacagctat 508141 aaaaggctga tccagccggc aatcgagcgt gaaatcagga aagagctctc agaaaaagct 508201 gatgaacagg cgattcatat tttctcagag aacttgagaa agcttctttt gcagccgccg 508261 atgaaaggca aaaccgttct cggtgttgac ccagcctttc gaactggctg taagctcgct 508321 gtgtcagatg agaccggaaa agtcttgaaa attgatgtga tctatccgca tgcgccagtc 508381 aacaaaacaa aagaagccca tgaaaaagtg aaaaagattc ttgagcagta tcaagtcgag 508441 atggtggcga tcggaaacgg cacagcatcc agagaaacag agcaattcat cgtcaatgta 508501 ctcagagaca tgccgcgcaa aatttattat gtgatcgtca atgaagcggg agcaagcgtc 508561 tattcggctt cagagcttgc cagagaagaa ttccctgacc ttaaggttga agagcgcagt 508621 gccgtatcta ttgctcggag acttcaagac ccgctcgcgg agctcgttaa gatcgatccg 508681 aagtctgttg gtgtcggaca gtatcagcat gacgtcagcc aaaaacgctt aaatgaatct 508741 ctgcggtttg tcgtcgaaac tgtcgtaaac caggttggag taaacgtcaa cacagcctcc 508801 gccgcgctgc ttcaatatgt agctggatta tcgaagtctg tagcaggcaa cgttgtcaaa 508861 aaacgtgagg aaatcggaaa gttttcaaat cgaaaagaac tgaaggacat cccaaggtta 508921 ggtgcgaaaa cctatgagca atgtatcggt ttcttaagag tgcaggaagg gacagagcct 508981 ttggatagaa caggcatcca cccggaaagc tataaagaaa caaaagcact tttgaaaaaa 509041 ctcggacttt caacagaaca tatcggcacg gcggaattga aggacaaaat caatcagctg 509101 gcgctctctg aaacggcaaa agagctggga atcggcgaaa tcactctgaa agacatttgt 509161 gaacagctga caaggccgga acgcgatcca cgcgataagg tgcctaagcc tttgctgaaa 509221 acagacgtcc ttcagctgga agatttgaaa gagggaatgg aactgcaggg caccgtgcgc 509281 aatgtagtgg acttcggagc gtttgttgat atcggagtca aacaagacgg gcttgtgcat 509341 atctcaaaat tgagcaatca attcgtcaag catcctcttg atgtcgtatc tgtcggcgat 509401 attgtgacag tttgggttga cggcgtagat gtacaaaaag gcagagtatc gctgtctatg 509461 gtaaaataaa agcactgctt acgagcagtg ttttttccta tagaaatacc agcattgatt 509521 cagcagttta atttggtaat tatctttttc aaggaacgct ttttgcatct gctttttaag 509581 ccaatttggc ataggctcat tcctcctcag cttttatcat aagagggaca gtgattacca 509641 tattgtatgc gaacggtgaa ttgtcccgtt caatgttttt taagtgaggt gcaccatgga 509701 taacaaagag cttcaaaagc tgacagagga tatttctgaa acatatttta aaaagccgtt 509761 ccgccatcag gcgcttttta atgaccggct taaaaccact ggcggcaggt acctgttaac 509821 ctcccataac attgaattga acagaaaata tttgattgaa cacggcaggg aggaactgat 509881 tggcatcatc aagcacgagc tctgccatta tcatcttcat cttgaaggaa aagggtacaa 509941 gcacagagac agagatttta gaatgctatt gcagcaggtc aacgcgccga ggttctgtac 510001 accccttaag aaaaaagcgg aaaacaaaaa aacttatatg tatatctgta cgacctgcgg 510061 ccaacagtat ataaagaagc gcgccatgaa ccctgacaga tacagatgcg gaaaatgccg 510121 cggaaaaata aaaagaattt tttcgtgaaa aaggttgacg aatatggcaa gcctatgtta 510181 cattataaaa gtcgtcacga gagataaata aaaacattta cctcttgaca ctgcaaatca 510241 aggctgatat aataagtctt gtctcattat tccacagtag ctcagtggta gagctatcgg 510301 ctgttaaccg atcggtcgca ggttcgaatc ctgcctgtgg agccatattg gagaagtact 510361 caagtggctg aagaggcgcc cctgctaagg gtgtaggtcg cgtaagcggc gcgagggttc 510421 aaatccctcc ttctccgcca taagatttcg atataagttc tcaaccatcg gcccgttggt 510481 caagcggtta agacaccgcc ctttcacggc ggtaacacgg gttcgaatcc cgtacgggtc 510541 attccatttc gttgggctat agccaagcgg taaggcaacg gactttgact ccgtcatgcg 510601 ttggttcgaa tccagctagc ccagccattt ttatttttga aatctaatag taagagccat 510661 tagctcagtt ggtagagcat ctgactttta atcagagggt cgaaggttcg agtccttcat 510721 ggctcaccat ttgtcttttt gcgggtgtgg cggaattggc agacgcgcta gacttaggat 510781 ctagtgtctt acgacgtggg ggttcgagtc ccttcacccg cactttattt acaaagtgca 510841 cgcaaatctg ttttactagg ttaagagcct actaaaccag cacaacacaa tttaatgatc 510901 acgcggtcgt ggcggaatgg cagacgcgct aggttgaggg cctagtgggt gaataacccg 510961 tggaggttca agtcctctcg gccgcatctc aataatacca agggtttaac cacctttggt 511021 attatttttt tgtgtggaaa atacggctat gggagaagac ttgctcacca aaactcacca 511081 gttacttaaa gtaagtcatc caaacggtcg gcggttcctt ctgtttatta ggaaaaagat 511141 atccgttcat tgtaaaagaa acgaaccatg tcctattcgt tcaaaaaaac taaagggtga 511201 tacatattat acatgattaa tatgtatcac ccttttcttt cttgttcaac aatcgcgctt 511261 gaggagaaca taagctaata caactgactc gatttctaaa gttgctccat tcttttttta 511321 aacaactcat ccacaacctg ttttaaaatc tcgtacgact gaatttcctt gctcaattcg 511381 taaatattag ataacacaat taattcatct gcgtgataca tttgttggaa atcaattagt 511441 tcgcgacgaa ttgtttctcg atcacccatg attgtatacc ccagtcgact gtggagaatt 511501 tctaattcaa actgtgataa cgattctagg aagttttcag tgggtggaat aagcttactt 511561 aaattatttg tataaatatc aatatacacc tgcaaatgac ttgcagaaat aaaagatgcc 511621 tcgtctatag attctgctgc aatcacatta atgcaagcga tcacataagg ttcttgtaaa 511681 taagaagacg gttggaaatt ttctcgataa atagagagcg cttcttccat cgaatggggt 511741 gaaaattgag cgccaaatgc atagggtaaa ccaagctttg cagcaatttc cgctgaatcc 511801 gttgaggatc ctaacacaaa aacaggcaca tgcgttccaa tacccggata agcgcgaacc 511861 tcaccctgta cactcttatc cccgacaaaa cgcaaaatat catttacttc tctttcaaag 511921 aaaaacactc cattatggtt ggaacgacga atcacatcgg ccgttttttg atccgttccg 511981 ggtgcgcgtc ctaatgccaa atctacacga tttggatata atgtttcaag tgttccaaat 512041 tgctccgcta cgattaatgg ggaatgattt ggcaacataa taccccctga acctacgcga 512101 atgtcttttg tatttgctaa tatatgttgt acaattgata cggttgctgc acttgcataa 512161 gcgtcgtgat tatgatgctc tgcaaaccaa atccgtttat agcccatatt atctacagct 512221 ttagctaatg acactgcaga atcaatccct tgtttcattg tttctccttg tcttaatgga 512281 gcaactgata aaacagatat atcaaatttt ttcataattt cacctctaaa ataatgaact 512341 tatacaagat caatggaaaa aacattttga aaaattgttt catattaaat ggtgtccatt 512401 cctctttgat ttgcatgcaa ataaatatat actttctcaa acgatcaata cataggcaaa 512461 ataaagttat ttcacaattt cactttactt ttaaagtttt aagcaaacat aaaaaaatgt 512521 tcagtgaaca aaatatgtaa aatacatctt atttttcaga aaggatacaa gaaaatgatt 512581 gatgaaatag ataaaaaaat acttgatgag ctgtctaaaa atagtcgcct tacaatgaaa 512641 aaattagggg aaaaagtaca tctcactgca ccagcaaccg catcaagagt agtaaagtta 512701 atagacaatg gcataataaa aggatgtagt atcgaagtga atcaagtgaa attaggcttc 512761 tctatacatg cttttcttaa tatttatatc gaaaaaatcc atcatcaacc ctatttagct 512821 tttatagaaa cacaagataa ctatgtaata aacaattata aagttagtgg agacggttgc 512881 tatttgcttg aatgtaaatt tccttcaaac gaggtattag atcaattttt aaatgactta 512941 aataaacatg caaactataa agtgtcgatt gttattggta aatagttaac tttataaaac 513001 ggagatgtgc ggtcatataa catgatatat atgctctaaa aaagccctag gttggatatg 513061 gaatttacca agctggggcc tttttataca ttataataac aagcgcatta ttcatcagac 513121 attaatgaag tattataatg cttttttact tccttaatag acaaataaag ctgatagttt 513181 ccatacttca ataaatcatt cagaaggtga tttaaaactt cttgtgaatg aaccgttacc 513241 ttcagaagat aacatgcatc tcccgaaaca cgatgagctt cgctaatttc attacgagta 513301 gcaataaatt tcaataaatc atcatgcata tatgcattca tgaaaaagaa gacaaaggct 513361 gtaaaagaaa accccatctt caattcatca accacaatcg aatatgcttt aatgataccg 513421 ttatcctcca tttttttgat gcgattgcct accgcttgtc ctgtcatatg aattttttca 513481 ccgatttctt tccattgtat ccgagcattt ttatttaata attggagaat ttgaaaatca 513541 attgaatcaa tttgcatagt aactcctttc acagtgaaaa agttttacaa aatagtattt 513601 catgagacca tcgaaaattc aatggaaatt atatatcctt atacagtata aaaattttaa 513661 gaggtgaaaa aatgacaaca gctttattag tgattgatat tcaaaatgat tactttccaa 513721 atgggaagat ggctttaaca aacccagaga aagcagcaca aaatgcggct aaactacttt 513781 cacactttag aaacacaggc gcacctgtct ttcatgtaca gcatatcaca gaaggtaaca 513841 tcgctcattt tttccatcca aatacagaag gtgtcgaaat tcatgagtca gtacgtccat 513901 tagagaaaga gacagtcatt gtaaaacata tgccgaatag ctttttcaat acagatttaa 513961 atggaaagct acaagaagaa ggggttaaag aattagttgt ttgcggtatg atgtcccata 514021 tgtgtattga tgcaacagtt cgttctgcag ttgaacatgg ttatgtatgc caagtggtag 514081 aagatgcttg cgcaacaaca acattgcaaa ttgaagataa aatcgttcct gctgagcatg 514141 tccattacgc atttatggcc gcattaaatg gtgtctatgc aacagtaaaa accacagagg 514201 catttttaaa ataaaagaat ttcctgcgcg aacataacgt ctttcttttc acaagaaaga 514261 tgattcaaca acttaaaaaa ggatgttcag aaaaatactt ctggacatcc tttattcatt 514321 atcttttatt gtttttcagt atcattattc ccatctgata aaagatcaag atgtcctgtt 514381 tttgatccat agtaagacca tatacaggga ttgtttttgc cataaatata gatattgatg 514441 aaggtttaca taaagcacct aattgcttga tttactttaa tgttagatcc ctcaataact 514501 ccattctctt ctaatttctc tactctagct gtagctgctg ggcatgttaa atgtactctc 514561 tcccagatct ttcattgaat tcggctatta tacataattt ctctataatt ttttatctgt 514621 ttgatctatt tgaacgttaa ttcctttcga aaataaagtc aaagagttaa aacacttttt 514681 tttatctatg tattcgaaca ctgctgatat tatacactta actctgtcga tctaagacaa 514741 ataaaaaaag aaagtgagtt gtaaatatga atattacaca aattcgaaat gcaacaattg 514801 ttgtaaaata cgcaaataaa aaatttttga tagatcctat gttagcagag aaaggtacgt 514861 acgctacttt ccctgaaacg atcagacaag atttatttaa tcctttggtg agtttgccaa 514921 catcaattga taacattctg gatggcgtag atgcggtaat tgttactcat ctacacctag 514981 atcactttga tgatgtggca aaaaacgtat tgccaaaaaa catcaaaatg tttgttcaaa 515041 atgaagcaga tgcaaaagaa gtaaaagcaa gtggtttcaa aaatgtagaa gtgctacatc 515101 aagacactgt ttttgaaggg atccaattag taaaaacaaa aggtgaacat ggcagagggg 515161 aagagttatt aaacttaatg ggtgatgttt gtggattagt attcaagcac ccaagtgaaa 515221 aagttttata tgtagctggg gatacagttt ggtatgatgc tatcgaagac gagattcata 515281 cacatcaacc agaaatcatt gtggttaatg gtggagacaa tcaaagatta gatttaggtt 515341 cactcatcat gggaaaagaa gacatctatg aagttcacaa ggctgctcct catgctaaga 515401 ttatatctgt tcatatggaa gctgttaacc attggacact atctagagaa gaattaaaaa 515461 actttagtaa agaaaaagga ttctcaagta atattttagt gccagaagat ggcgagtctt 515521 acacatttta atatgaacac cgacaaataa atagaagaag ctcataatta taaaaactaa 515581 tcatgagctt cttctaataa tgaatatttt aaattttaaa tatatcgaaa atcctaaata 515641 tacggaataa caaaaatgga atgttccaat gatgacaaaa aaacttgaaa agcaacaaag 515701 atgtgtcgtt aggaggtaga attcatggta atgacaaaaa aagatacaaa tatatcaaca 515761 cagcagcctc tttggttaca aggttatatt gattcaccag aaaaacaaaa ccaactttat 515821 aaaaaaacat taaaaatctt gattttttca caaatatttg ggggagcagg acttggagct 515881 gggataacag ttggggcgct tcttgcacaa gatatgatag gatcggaaaa tgtagcagga 515941 attccaactg ccctctttac ttttggatct gccgtagctg ccctgcttat aggagcatcc 516001 tcacaacgtt ttggtcgcag agctggactt gcaggtggtt tccttatagg cggattaggt 516061 gctataggtg tgataatcgc ggctttaatt aacagcgttg ccctattatt tgtttctctt 516121 cttatttatg gagcaggtat ggcttctaat cttcaagttc ggtatgctgg gacagacctt 516181 gcaaatgaga aacaacgggc aactgctgca agtatggcct tagtttctac tactttagga 516241 gctgtagtag gtcctaactt agttaataca atgggggaat ttgcagattc aattggtgtt 516301 cccaatttag ctggtccgtt tattatgtca ggagcagctt ttataattgc tggaattatt 516361 ctcttaattt ttcttcgtcc agatccgctg tttgtatcaa cagctattgc gaatgctgag 516421 aaaaaagacg ataaagtaca aataggagga agtctaaaaa atcctgctat agacaaaaaa 516481 ggaataatgg taggagctgt cattatgatt ttagctcaac taatcatgac agctattatg 516541 acaatgacac cggttcacat gggtcatcac ggtcatggtt taagcgaagt gggattagtt 516601 ataggactcc atattgcagc gatgtatctt ccttcaccat tgactggttt attagtagat 516661 aagtttggtc gcacaactat ggctattgct tcaggtgcca cacttcttgc cgctgggttg 516721 gtggcagcta ttgcaccggc agactcatta tcattgctaa tcctagcact agtattacta 516781 ggggtaggtt ggaactttgg tttactaacg ggaactgccc ttattataga ttcaacacat 516841 ccatctctac gtgcaaaaac acagggaaca ttcgatgttt tattagcact atcaggagca 516901 gcaggtggag ccttgtcagg aatggttgtt gcacattcta gttatacaat actatcaatt 516961 tctggagccg ttttatcatt gttactcatt ccagtagtta tttggtattt tagaaggatt 517021 caggaaaaag cataagctta tataactgtc tttgaagaac ctaagtagac attactttac 517081 cggaacctcc tttttctatt tattatagta aggagttgac atggcattag tggcatgtgt 517141 ataactacac aattatttgg gattcagaga gcatgtaatg aacggaagag ataattattt 517201 atcactttta ttattgtacg gtgttcttgt ggcattaagt tcagtcaatt ttggtctaac 517261 tgttttcttt ttgttttcat cacctctcca tattattaac aaacacgaaa aggattttaa 517321 tgaaaataaa atgattagcg tatgtatctc taattttcaa aatgaatgaa tagtcctttt 517381 taagatttac acacttattc tccaaggaaa aatgactcaa tttttcgatt ttttatgtaa 517441 atcaaaaaag aatcatgtta gagtaggtgt gctgaaaata attcaaaaaa ttattttgcg 517501 atatgattaa agtaatattg ccagagagtt tcaattggac aaaattgtaa gtgtttaata 517561 cactggggct gcaatcaaat atgcacctgg aatcaattgc taaacggggg agtttatatg 517621 aacaacaaga aaaatatctt tgatattgtt atgtacatta ttttcggtgt gttaagtctt 517681 tttctagttg caaaaactga ttatggcact ggagttttag tgtttgttgc aattttatac 517741 ctcgctgtta ttgcttataa aattaagcaa gtatttagta attcagattc ttaaggtgta 517801 acacaaggag gatttcaatt gagaaagaaa agagttatta cttgtgttat ggctgcatca 517861 ttgactttag gctcactttt acctgcaggt tacgcttctg caaaggagga ctctaagaca 517921 accccttctt acgaagaact agctctacat tacaaaatga aaagtgaaaa gatttcatcg 517981 aacgggaaat tagttgaaat tgagtatgtg agtggaaatg aaactcacaa agttcagatg 518041 aacggaaata atcatactgt aaaagtcgat ggcatagaac aaaaaggttt aaactttgag 518101 tatgatgaaa atgttgctaa aagaacaaat tatgaaaaca ataatttgaa atcaaatgaa 518161 ttcacaacac aggctgcaaa acctaaaaag ggataccatt atgtggggac tttatctggg 518221 catacaaaag cagctaaaaa tgcgttatca gttacaatgt cattagtcgg tattgtccct 518281 ggcttgggat gggggagtaa ggctgccact attttattct cttattgggc aaaagaacaa 518341 atccctgatg cgtattataa atatgattta tacgaaaaag gagcaatgac tgatagttgg 518401 tatcagtatg ctacagttca attttttgaa gataaagctc ataaaaagaa aatgggcaaa 518461 ccttggacaa gtactcctgc aaaagtagat ttacctaata gctaatttta aaatcacttt 518521 gtctttataa aggacaaagt gattttttgt tatacagaag taaaatccct cgtctgagga 518581 atcttggaaa aaacttggtt caattttgat ataacatgtt tttttcttgc taatttagtt 518641 tttctatgta tcgctacaca ttctaaataa taagatatta gccggacggt tgatgccaag 518701 ctcaaaagtt tatatggaag tcaaagcata aaaaagggtg ttacaacgtg tagtcttctt 518761 tttattttgc caacgtaaca agtgtgaaag taatgatttg taggatcagt taagaaaggt 518821 ttaagattag atattgaaaa attttatata ttttcaataa aatactggta ctataataaa 518881 tgtatacaga ttgtatggag atgtaattaa ttaaaaagga gttttttaat tgcgttggag 518941 taaatggttc aatgtttttt gtatagtagc attgggatca atatatggtt ataaattatt 519001 tactaaccaa gaagtcagta ctactcgttt aataatagct tctgtaattg tgttgtggaa 519061 tattgttgga ctttttagca aagaatcagt aaaacaagca cagcaagcaa attaaaagtc 519121 ataaagttgg gaaagaagga tgttacttat gtagtatcct tctttattat tccttgaaaa 519181 atgaaacaaa ttggagatta cagcttatat aatcaattga agtcgttgat tattttcatg 519241 aacaggagat ttaatgcttt ctgatgaaat attatcgtat gaatgttgca agaggaaacg 519301 ttactcaaag attacaggga tgtgatgaac actcctcttt atcgcactca cctgacccca 519361 aattgttggg gaagggcagg tacggaagat agagtatttt ttcttcgtaa caaatcgaaa 519421 aggttggata ataaaaaact tataatctaa ggcggtatat agttgtgaaa aaggcgttat 519481 ttcttatatt agaccagtat gcagattggg aaggtgttta cttagcatct gcattaaatc 519541 aaagagaaga ttggtcggtt cacactgttt ctttagaccc tattgtaagc tcaataggtg 519601 gttttaaaac atctgtcgat tacataatag ggttagaacc tgcaaatttt aatttgctag 519661 ttatgattgg cggggattcc tggagtaatg acaataaaaa actattacat tttgtaaaaa 519721 ctgcatttca aaaaaacatt ccaatagcag cgatatgcgg tgcagtggat tttttggcga 519781 agaatggttt gctgaataat catagccata caggtaattt tgtttactta tggaaagatt 519841 acaaacaata taaaccgatt agcagttttg tagagaaaca agcagtaaga gataaaaatt 519901 tggttactgc taatggaact gcccctattg aatttactaa tttaatttta gagatgattg 519961 attttgatac tcctgagaac atagagaaaa tgatgtatat gaatcgttat ggtttttatc 520021 atttttgtga taaatatgga aatccatttg ttgattaatt tgctggaaat gattttcccg 520081 aatagggggc tttgcgattg agttgaattt cctaataaag caaagaaaga tgatttgagg 520141 tcaagtttaa caaataatgc catcaatatt aatttgcagt tatttccgat tcctgatata 520201 ataaagaaga attatttttg ttcggtgtaa aggatagtat gaagattgac ttttcgtctt 520261 gatgatactt tgggcaagga tagtatatac tgtgtggtta cacactagga ggcaacaaaa 520321 atggaacaag gtacagttaa atggtttaat gcagaaaaag gttttggctt tatcgaacgc 520381 gaaaatggag acgatgtatt cgtacacttt tctgcaatcc aaagtgacgg attcaaatct 520441 ttagacgaag gtcaaaaagt atcgtttgac gttgagcaag gtgctcgtgg agctcaagct 520501 gctaacgttc aaaaagctta atcttcaatc gtttatacaa acaggctctt tatatagggc 520561 ctgttttttt atgtctatat catactcaat aaaaaaccct actcaacgtt cgagtaggga 520621 gatgctacaa ggtaatagaa aaagatttaa aacttcaaag gtttgtttac agtataacat 520681 actggattga caatatgcgg aatgtatata aattatttaa tgttttgttc aaatatagat 520741 aactgactct ttttttcact aacctgttcg ttcatttaag taagattaga tgaattataa 520801 aaatggtttc atctaaatgt tatcaactcg catatctctt ttatgagaag aagataaaca 520861 attattattc aatgttgcag tggatataag aaattcttaa aaataatgag gagatcgatt 520921 gtttttttct cctggaaata atcacttaga gatacctaaa acaatgaaag ccctacctct 520981 cttccatcct tacggctcct tgtccgtgcc agtgtgaatc aggatactaa aaaaagtgac 521041 tattttattg agttttttgg taaaacttca atcttcgcag aagaaatgta aataataaaa 521101 atggattaga atgtaggaat aacaaaagag gtcgttaatg ttctaaacat aagttggaga 521161 agatttgctt ttcatcataa tattccgaaa tatcttttgg gatgtatcta accaaaactt 521221 tttatttgtt tttcagtgat tcctttaatt acttccagtt cactaatcaa aaattcatat 521281 gcattatcca gcattttttt ttcgcttgca ttaagtgctt tttctttctt catacgcatt 521341 aaatcacgta caacttcagc accttcttgt atttcacctg tttttatttt gtccgtgttt 521401 attttgtacc tttgcttcca tggcagtaac ctatcggatt ctccatgctg aaaaatgtgc 521461 ataatgtgtt ttaatgcaag tatatcggta actggtcgta tattcgaact caatatttta 521521 ctcgttggaa tcataactgt catattactg attgacattc ttatgacata atactgttgt 521581 ttttcctcta agaattcttt ttcttctatg gcttcaatta tacctgctcc gtgcattgga 521641 taaacaatgt tatcgccaat ttgaaacata tcatccacct ccatatatgg tatccttctt 521701 aagattacca tatatggagg tgtaatatca aaattttaat aataacatga tcgaattttt 521761 gatgtcaata acttttttga aaaaacagat caagcaaaaa caatagggaa cgtgtcggat 521821 ttccaatcag gaaaaggtca attgatccgt gtgagcagtt tttcattggc tcaatgacat 521881 tacagaaatg atttgagtag ataagaaaga acgatattcg tgaaatgtca gctaaaaata 521941 tttaaagcac atgattaagt tctaatttct ttaccgattt gatatggata acggccgact 522001 tacttaatga tgcattttca cttatcttgc aagcagaaaa aggtttgttg ataaacattt 522061 agccaccaaa ttggcattat tatcagggaa attgacaacc ttcaaatggg tattgaggcg 522121 agaagaaaaa taaagaaagg agagattata aatgaagacc agaacataaa gaagtaaagg 522181 ggaaagaaca aggttaattg aaaagcaaac tatataaaat agtttgcttt tttttgttat 522241 gacttcactt ctttttcttt ctctttaatg actaataaaa caccgctcag aattaaaaac 522301 gaacctatcc aaaatgtccc gcctatttgt tctccaagca gaatccatcc gagtaaggtt 522361 ccaaccagag gctgaaaaaa gaaaaagagg cctccacttg aggcatttaa taattgtaag 522421 ccgtggttcc acaataaaaa tgcacaagct gttgaaacaa ttcccaaata caaaaggcca 522481 cctagaattt tagggtcaag cagtagtggc gtaaaaatcg tgctagggga gtaccattaa 522541 cagggactcc atttattaat agaataaact ttatgaattc atttttttgt atgataatgg 522601 cgtcatattc atcgcttgtt gaaatttact tatgaaataa ctggtactgt taaatccaac 522661 ttgataagac acttctgtca cattggattc agggtgttgc agtaataata agcttttttg 522721 aattctataa tccattacat aacgtaatgg cgtcttattc agcattcgtt taaaataacg 522781 gcagcattca gaacggctca gttggccagc ttttgcaatg tcctctaatg tgattttttc 522841 aacataatgg agatggatcc agtttaacat ttgtttcatt cgatgacttt ttatcatttc 522901 agattgatcg tactctaatt gaaaaccatt aacgaccagg tttttccaca ttaacgttaa 522961 ttgcatcgta atgtcaatct catagagcga tgtcttttgt tgaatcaatt gatttatttt 523021 tttaacagca tctagaatat tttttgccca ctgttgattt ccagccaaaa ataaataggg 523081 caaattggtt gaaaacatat agggctgaac atagcttgaa tacagttcct gagataaaac 523141 gaaatggggt gacacattca agcaaatata cgtacaatcc gagccttcct tttcttcggc 523201 catgtgcagg tagccgctat tgataaataa tccatcccct tcgtgaacct ctattttttc 523261 ttcatttatt tgaaagagag ctatcccttt tagtatcaaa acaaattgga tttcatcatg 523321 ccaatgaagc ggaatatagc catttatatt ttgattgatc gttgtcttgt agcaggcaac 523381 tggcaattct accgttcggt gctctgttaa ttcttttaaa ttttgatcga tcacaaaatt 523441 cttcattctg acttcacacc tcaatatatt tatatttttt cattcaattt gagtattttt 523501 tatcatgttt tgcatttatt ataacactat tattatattt attagtgagg agtcatgtat 523561 gaatacttcc aatagaagaa tgggattgtt ctatgttatc acaggggcga catgttgggg 523621 gattggaggc acagtagcca aaaaactttt tcaagaatat caaattgatg tcaattggct 523681 tgtaacgaca cgcttgctta cggctggaat gttactttta atgctgcaac tgttcagaaa 523741 ggatcgttcc caggttattg aggtgtggaa acacaaagcg tcggctggcc agcttctaat 523801 ttttggccta ttgggaatgc tagctgtgca gtacacatat atggcatcca ttcaacatgg 523861 gaatgctgcc gttgctacgt tattgcaata tttatcccca gtaatcgtca ttatctacac 523921 gctgttgcga aaacaaacgg ttcttaccaa acaagatatc ataactgttg tacttgcttt 523981 agtgggttgc ttttttttgt taacaaatgg ttcaatgtct caactttcag tgccggcagc 524041 tgcagtagta tggggagttt tatcaggatt cgcggcagct ttttatactt tgtatgccgt 524101 tggtttatta aataaatttg attctcttgt cgttgtaggt tgggctatga ttattggcgg 524161 ttttgcattg ggttttatcc atccgccatg gcaactggat tttcaacgat taactgctga 524221 ggcgtatgca tatatcttat tcgtgatatt atttggaaca atgattgcgt tctggttctt 524281 cataaaaagc ttggaaagcc tctctccaaa agaaacaagc ctactaggca gtctagagcc 524341 tctatcagct gttgtaacaa ctgtcgtttg gttaaaagcg ccatttggtt cttttcaatg 524401 gattggtgct atttgtatta tagggataac tttaatattg gctttacata aagagccttc 524461 tatggagagt gaaaaatcga tattaaagat taggaatcat gcaaatcggg atatataggg 524521 gctttttttg cttacatgac cggtccggca atgaaaaaca ctggtggagt ttgagccctc 524581 tcggcagtat caaaaatacc aagggttttg acgccctagg tattttttct tcaagaacct 524641 tcaatttttc ttctctgatt gaaaaacgta ttactttttt gtgattggta tccaaatttc 524701 acttttaaaa gatggtgatg ttacatcctt atgctcgttc cacaatattt ctggaccttc 524761 tatttgttcg taatttgacg atggaaacca ttcggaataa atgcgtcccc atacttcttg 524821 cagtgtatcc ggaaatggcc cgattgattc gaatacagcc catgttgagg caggaacttc 524881 aagccgtgag aagttatctg gacaccgttt cgttgtggct gcgccaatat agtgatcgag 524941 ctctccgttt tcctctgtcc gaccttcaga aaaattcgtg gatgcactaa tgaggcctga 525001 tggtgctaca ttagatagct cttttagttt atttattgct ttttcatcta aactttccca 525061 catagatgca atttccggat taattccttt gaaaataata ggaactcttt ttttaatgcc 525121 aacgatgcga aatgcctctt tttcttcaat acggtagttc atttcatttc ctcctttaat 525181 tgttagctgg aaggtcattc gtggataagc tttaagggaa tggccattaa atctggcttt 525241 tgatgggttt atgccatgta aattttggaa tgcccgtgca aaagaatctg gtgagttata 525301 accgtacttt attgcaatat caatcacttt tacattgctg tctttcagtt caaaagctgc 525361 aagagtaaga cgtctgcgac gaatatattc cgataatgaa atacctgcaa ggaaggaaaa 525421 catcctttta aaatgatatt cagagcagaa agcaagcttt gctgcctctt gaaaatcaat 525481 atcattagtg aggttttctt caatatactt taacgcccta ttcatacttt taagcaaatc 525541 catttatttg gcctccttta accaaagaat aacaggagtg aaatgtattt atccgacatt 525601 ctgtgcacag ttttgcagga tgacttatat gaaataaagt aagtgattca cttgtatttg 525661 tacaggtttt attgaagcat gctgttcata aaaaggcatc aataaaagaa agttataatt 525721 gtcttataaa cggcacattc atataattga gtgaaaaagg atgcgtatca tgcctatcaa 525781 ttcttttgaa aattatccga tgagctggaa gccatcgatt gataaagctg aaaagcctat 525841 ttataaagca cttgcagggc aattggaaca ggatatttta aacggagttt tattacctgg 525901 aacaaaactt cctccacagc gagaattggc cgattatcta gatttaaatg tgagtacgat 525961 ttcaaaagca tttaaagtgt gtgagttaaa agggctgctg agtgcgactg tagggagcgg 526021 cacatttgta tcgtatgatg cgttgtcgaa tgcgtattta cttgaggata ctaagccgac 526081 acatttaatt gaaatgggag caatacttcc agatcacgct tcatatgagc ccttgttata 526141 ccaactgaaa aacatggttc atgaggagga ttatgaaaaa tggtttagct atggccgggc 526201 aggtgaaagc ctttggcaaa aagatgcagc tgtaaagctc atccaaagag gcggatttga 526261 aacatccgtt gatcacattt tatttgcaaa tggagggcaa aatgcgattg cagcgacatt 526321 ggcgagtctt tgtaagcctg gagatcgcat cggagttgac catcatacgt accctggatt 526381 aaaaactgtt gcatcattgc ttagtgtgca aatcgtaccg ataaaatcag aaaacgatga 526441 aatgagtccg gagtcacttg aatatgcgtg taaaaacgaa aatattaaag gtttgtattt 526501 aatcccggat tatcataatc cgacgacttc ctttatgtct gttgagaatc gaagaatggt 526561 tgcagacatt gtaaagaaat ataatctgtt tgttattgag gatgcatcgt accatcttct 526621 caacaaaaat ccgcttccgg cactcgcctc attcgcaccg caacaggtta ttcatattgc 526681 aagtttatca aaatcgttag cgccaggcct gcgtttggct tatgtagcag tgccgagaca 526741 atataaggag ccaatatcaa aggcgcttta taatttaaat ataactgttt ccccgctatt 526801 agctgaactt actgctcgca cgattgtatc aaatcaattt gaagtcttaa ttgagagtca 526861 tcgtgaacaa accattcgca gaaatcaact cgtaaaccga tatgttgcgg gatatacatg 526921 tttaggtgtt gaaacaggca tttttcgttg gttgttgtta ccgggtaaaa tgtctggtgc 526981 cgaatttgaa gaattggctg ctcgacttgg cgtgcaagtg tatgcggctg aacgctttgt 527041 agtgggaaat agttgtcctg aaagggctgt aagggtttct gtctgtgcac caaaaacact 527101 tgaagagctt gaacaaggat taatgatcct gagacgtttg ctagacgatc ttacctaata 527161 ttgtttgcca tacaattatg acattgtatg gcttttttgt gcgtgttatg atgatccaca 527221 tctagaggga ggtttataca aaattggctt ttagaaagga aggtcagatg atgttagaca 527281 aggacagcgt aaaagcaata gatgttcaaa ctgcttcatt acagagctac atcagttcac 527341 cagaaaaaca aaaatcgtta tacaagcgta cactattcgt tgtgagtatc tcacaaattt 527401 ttggcggtgc ggggctggcg gcaggagtga ctgtcggtgc gcttattgca cagcaaatgc 527461 ttggcactga tgcgtttgct ggtttgcctt ctgctttatt tactttaggg tcagcaggat 527521 ctgcattaat tgttggaaga ctttctcaac gttatggccg tcgaacaggt ctttcagctg 527581 gctttatgat tggcggactt ggagcaatag gcgttattat ggcagcaatc ataaatagta 527641 ttttcttgtt atttatttcg ttgcttattt acggtgcagg tacagccact aatttacagg 527701 cccgttatgc aggtacagac ttagcaaatc ataagcagcg agcgactgct gttagtataa 527761 ccatggtttt tactacattt ggcgcagtgg caggtccaag cttagtgaat gtgatggggg 527821 atttcgctct ttctattggt gttccatcac ttgctggccc tttcatttta gccgcagcag 527881 catatatgtt agcaggtgtg gtccttttca ttatgcttcg tccagatcca ttagttatag 527941 caagaacaat agaagcggca aatgaagagc ctggtgataa aggacatttg gcggcaactg 528001 agcatacaga aaacaaaaaa gggataatcg ttggggcaac ggttatggtt cttacccaaa 528061 tagtaatggt agctattatg acaatgacac cggttcatat gagacatcat gggcatgact 528121 tgggtgcagt cggtcttgtt attggttttc atataggtgc tatgtatctc ccttcacttg 528181 ttacaggtgt tcttgtagat aggttgggac gtaccgcaat ggctatttcc tctggaacaa 528241 cgttgctttt ggcaggtgta atagcagcat ttgctccggg agaatctatg attcttctcg 528301 tcattgctct ttctttactg ggattagggt ggaattttgg tttgataagc gggactgccc 528361 ttattgtaga ttcaactgat actgccacac gagctaaaac gcaggggaca gtggatgttc 528421 tgattgcgtt gtcaggagct gctggcggag cattatctgg aatgattgtg gcaggttcaa 528481 gttacctcgc attatcactt attggaggga ttttgtcctt attactcatt ccggtggtgg 528541 tatggtctag gggccgctaa agggtaggat tgtttaattt acattaattt gttatattgt 528601 tagataaagt atattgcagc atctaatatt ctaacgaact atagttgctc cattaaatct 528661 attataaaga tttgaccagg attccttata gctgtgtcac tcactgcata ttctttaatt 528721 gaatcacata aaatggttat cggatttgaa aaaggcagga ttactcgctt taggtaaagg 528781 agtcataacg ttgttaaaaa ggttttctct tgttattgtt acactaatga tgtctatcgt 528841 tgttgtttta gcggctgcta aagagtcgcc tggagatcat gtcatctcat ttgatgaacc 528901 tattatcttg atgatctcaa ttggaatcgt tgtattttta ttgatccctc cattagtcat 528961 gtcctttttt ggcaatttgg ttgtaagaat aatatctggt gtataccaat gttttatcgt 529021 tttcactttt ctggggctca ttccaattgg atttcttatt cccaatggct ttttgacaat 529081 tctagtttct attgcaggaa ctttagtcag tatagctagt gttgccgtaa ccttatgcat 529141 tggcaagaat aaaaaagata tataatcatc gaattgttat tttttcagat tgtcagtgaa 529201 ataattatac aaaaagagaa ggcttgtggg ccttcttttt ttgttgttgc atcatcccca 529261 ctttgagctt aatctattga ataataagag aaggaaccta tagaagaata aaataaatac 529321 cgagatgtca aaaataaaac tggacttcat tattgtgaat tcacgtaaat gtaaaaagat 529381 tggaaagagg ggaattcctt catgacaaat agcagaacaa atccgaaggt tgatgaattt 529441 ttaagtaaag cgaaaaagtg gaaggaagaa tttgagaagt tgagaaccat cattcttgac 529501 tgtgagctga ctgaagattt taagtggatg catccttgtt acacatatca taataaaaat 529561 attgttttaa tacatgggtt taaagaatat tgcgcgcttc tgttccacaa aggcgtctta 529621 ttacaggata cagatggaat tctcattcaa caaacggaga atgtacaggc ggcgcgccag 529681 attcggttta caaatgttca ggaaataaat gagctagaaa acattttgaa agcctatatt 529741 cacgaagcca ttgaagttga aaaagccggt ttgaaagtgg atgttaacaa aaatattgaa 529801 ttgaacattc ctgaagaact tcaaaataaa ttcgatgaaa tccctgcatt gaaaattgct 529861 tttgaagctt tgaccccggg acggcaaaga gcgtacactc tttatttttc tcaagccaaa 529921 caatccaaaa cccgagaatc gagagtcgaa aaatatgtgc aaaaaattct cgatggaaag 529981 ggattaaagg attaggcacg ccaaggttca ggctaaagga atagcatcat agcgtaataa 530041 gatcatttct atagaagaaa aacaagcata gtaagatgct tgttttttct taggacaaca 530101 ttcacttact gctgaaatgc ttctaacatt gtatgccact agacagcgtt ataaaatatt 530161 aatgcaacac ctagaaatct atccaatgaa atagctcaat ggtatggctc attacattta 530221 gaatgcctag gagaactaat agaaccggaa gatttttagc aagttactac actccaaact 530281 ttgtttttgt attaatatac cttattaacc attgttttta gtcaggtgca gacaaacgaa 530341 tactgattaa tgaatcatca tgatatcaat gagccgcttg attttttcat cgtcgcctgt 530401 atcaacgtac actgtttttc tgttttttat gatactctca gtcacttccc gcatgacgcc 530461 tttttctata tcatcagcgg aatcccagcg taaaggcaca ttatatacat gaattgtgcc 530521 atccccattg ccatgataag tgactgatcc atccactaaa cgagaacctg ccaactgggt 530581 cacattttct ggatagctgg cacttgtatc atcattagga ttaattggct cgccagccgc 530641 aatatgtcga acatttaatt catctatctc ttgattaggt ccaagttgaa gccaaactct 530701 ggcatattca attttttccg aagagtatgc tgccaataca ttgtcttctt tgcttttctc 530761 ttctgctgaa gaggtatcat ttgcagcttt tgttgcggat tcttctgatt ctgttattgg 530821 ctccgcttca tccttgcgta ttttggtgct ctcttcaggc tcagtgtgtt tttcgtcagt 530881 ttgcacagca gaagcttgat ttgaaggttg ttgtgcttct ccatccttac tgtccgtaca 530941 tccagcaagc aaaatcataa gcagcagggc agtattgcaa taacatatct ttctgcgttt 531001 cttcattttt tcattcctct ctattaattc aggtcagctt catatataag tttatgtatc 531061 taaatattac catggaatag ataggatgat attgaaaact gtttaagaag aggaaacgat 531121 cttgaatagc atcgcgaaaa cctaagaatc ttaagaagtt ttgccccttt ttcttcaggt 531181 attgaatgta aagtgggata taaatgcaaa caaaaacgaa atgccttatc cacctcgtgt 531241 catggcagaa aaagtggggg atttattaga gcggatttga taatggcggc aggtaaatgg 531301 gtgttgactt atatgtctaa gcgggagact caagtctgct cgatcgcata caaaatacca 531361 agggccagca acccttggta tttttatacc ttcatgcatt tttgaagttt atgcttaaag 531421 gtctgcctta ctttgcaaat cgccgagctg ctgcaacgca catgataacg gcgatattca 531481 ctgctacgag tgcccagccc actttctcgt gcagaatcac tgaggcaagc agcagtccaa 531541 aaaaaggctg gagaagctgg agctgcccaa ccgctgcaat tcccccttgg gcaagacctc 531601 gataccagaa cacgaagcca atcagcatgc tgaataagga tacatatgca agactgagca 531661 gtgcgggaac gccgatcgcc gaccatgagt ccggcgtaaa aaagaacgac aatggcagca 531721 taagaggaag cgacagaacg agtgcccatg agatcacctg ccaattcccc agacgccgtg 531781 aaagtttggc cccttctgca taaccaagac cgcatacgac aatagaagcc agcatgtacg 531841 cgtcgccaag cggggatgaa cctcccccct gaatgagggc gaaacctgct actaacaagc 531901 tgccggcagc tgagaaaatc cagaagacgg ggcgagggcg ttcacccccg cgcagtacgc 531961 cgaagactgc cgttgcgagt ggaagaagtc caatgaagac aatggcgtgt gcggatgtga 532021 catgctgaag cgctaaagct gtcagcaacg ggaaaccaat cactacgccg aacgctacca 532081 ctaacaatga aatgagatct cttttggcag gatgctgctg ccggaagatg agaaggagac 532141 ctcccgccag tacaccagct atcgcagcac ggcaaactgt gagaaataac ggatcgaagt 532201 ctgacacagc caaacgggtc gcaggcagcg agccgctgaa aatgagtacg cctataaaac 532261 catttatcca gccatttgtt gttttgttca ttataatcac tccacatatc tttcttgttc 532321 attgtctgta ttttcttaac aaaaccagca gctaaggatt acaatgacta taaactggaa 532381 ttggcctttt ataaacagcc agttttcata aaaaaatgca taccagttag gagaacaacg 532441 cgcaaatgga tatcacgcct tttttgaata gaactctgga tattccgctt tatcagcagc 532501 tttatcggta ttttaaagaa aatatgcatc ggggccgtat tcaaaaagga atgaagcttc 532561 cttcaaaaag actcctggcg aatcagcttt ccatcagcca aacgactgta gaacgtgcct 532621 atgaacagct cgctgctgaa ggttatattg tgagcaagcc aagaagcggg tggtttgctg 532681 attatcatga ttctgatttt gcttatgata gaatgccaag cacaacaccc attcaacaag 532741 aagcagaaga aaataaacaa tggattgatt ttcattatgg gaatgtagat tcttcttact 532801 tccctttttc cgcatggcga aaaagcatgg tcaatagctt agaccaatat ggacacgagc 532861 tttatcggcc gggacatgtt ttaggagagt ttgagctgag aacactcatt gcagagtacc 532921 tgtatcaatc tcggggggtt cattgcggcc ctgaacaagt gattataggt gccgggaacc 532981 ctattctgct gcaaatcttg tgccaagttt ttgagccgaa tatttctata gggtatgagg 533041 atcctggtta tccaagagca cgcaagattt ttgaagccaa ccgcatgaat attgttccta 533101 taccagtcga tgatgaggga atctgtatac agaagatcaa agaacagcag ccaaaccttg 533161 tatatgtcac accttcccat caatttacgc tgggaaccat aatgacaata aacagaagaa 533221 ttcagctgct caaatgggcg gccgaaaatc aatcctttat catagaggat gattatgacg 533281 gggaatttag gtacacagga cagccggttc cttctctgca agggcttgat cagcataacc 533341 gtgtcattta tatgggcact ttttctaagt ctcttttgcc ctcgctgcgt atcagctata 533401 tgattcttcc ttcgcctctt ttaaaaaagg gtcatgaaat cacgtcctta tataagcaga 533461 cagtgtcctg ccacagtcag ctaaccctag ctgaatttat aaaaaatgga gagtggcaaa 533521 aacacatcaa cagaatgaga aaactttacc gcaaaaaaag agccattgta ttagaggcag 533581 tgcaaaggga attaggagag catgtcagaa tccgcggaga aaactctggg cttcgtatct 533641 tacttgacgt ttatttgcca tttggtgaaa aagagttaat tgagaaggcg aaaaaacatg 533701 gagtaaaaat ttatcctgtt tctctttctt atcaacatca tcctcctaca aaaacggtct 533761 cgctcgggtt tgcaggggtt tctgaatccg acataagaga aggcataaaa aaactgaagg 533821 ctgcctggaa gatatgaggg agctttcagt ttagcaaaac ggccaagtga cgactaagtg 533881 ttgagagctg ttcaatattt tttaagtata tgatgagtgc ctgcagtcca ggccacgata 533941 cgtctgttta gcgaaaaaca gaatttttta tttgctcctc acagtgctaa aataaacaaa 534001 atagacaatt gaaaaaatag aggtgtaaga atgaagttag atgagtttac aattggccag 534061 gtcttcaaaa cgaaatcatt aaaagtatca aaagatgata ttatgcggtt tgcgggtgaa 534121 tttgaccctc agtatatgca tgtagatgaa gaaaaagcga gtaaaggcag atttaatgga 534181 attatcgctt ccggcataca aacactggcc atatctttta aactttggat tgaagaaggt 534241 ttctatggag acgatattat agccggaaca gagatgaatc atatgacatt cataaaaccc 534301 gtatatccgg atgatgaatt gtttacaatt gttgaggttc ttgataagca gccaaagaga 534361 aatgaattgg gaatactcac agtattgcta tctacttata atcaaaaaga agtaaaagtg 534421 tttgaaggtg agttatctgt attgatcaaa cgataactca gaaagcccgc ttttcgcggg 534481 ctcgattgaa gcagatgggt gaaagatgtt agcgggtttc ctttgaaaaa taagaggtta 534541 aaacatcata aacaataggc aaagaagtaa atccctcatc ttctagaaaa tgacctccgt 534601 gctgaacttc atataacgca gcatcaattt gttgtgccag atccttgctg aatgaaaaag 534661 gcacaatttg gtcgtcctta gaagcaatga cagcacggtg cttcgcggac tcgatgattt 534721 tttgatgatc aaacgatccc tgtgtaaatt catctaacat ctgtaaagtg ggcaatgatt 534781 tggcaaagcc ggaaacaagt atgattccgc caagctgttt tcgtaattga agatgttcca 534841 aaaatctcaa aatggcgggg caacctaagc tgtgcgcaac caaatacgta ttttcatgta 534901 aagtgtgctg atataaagag agtgtatcca gccaatcctc aagtcttggc tggagcggat 534961 taggcatgtt taaaatgtct gcttggaccc catctgcgag cagacgtttt ttcagccaag 535021 ggaaccaatg atttgttgag gaggctctgt agccatgaat gatatagact tgttttgtca 535081 ttatttcctc ctaagaaata ttttcattca gtataaaatt cctctcattg ggaaacaagt 535141 acgcactttt ttgtaagtag ctttacatat gaggccctcc ttgtgccatt ccccacttac 535201 acatctcatc tatgagggga tacaaagatc gccctctgtc agataacgaa tactctactt 535261 tcagtggggt gtgagaaacc tcagaccgat gaataaggcc gtcagtttgc aattccttaa 535321 gctgtgcgct taacatttta tgggtgatga agggcatagc ccttttcagc tcgccgtatc 535381 tcatcgtttt ttcacaccct aactcataga gaattctcat tttccatttg ccccctataa 535441 gagataaggt gtattcaaat ggggcttgtt tactgcggca caggctattc attgtaatca 535501 aacctccttt tttaagtatc atatcagaat aaattaggat tttcggtgtt gaagtttgag 535561 ggcgattcac gatctgaagt gaaaggggcc gcttgctcaa caggcggcac ggtacatgaa 535621 tgttctaagt caaagagggt taccttactg ttagttactt tatttaaaaa aacgcatgtt 535681 tttagctgaa aatatctatt atggtatatt taaatataaa gaaatatttg agaaatgagg 535741 aatggtatga atacacccaa aaaacataag aaatttaaag cgaaaatgat tctccaaatc 535801 atcatggtta tcattggagg aatcatagcg gcatatggac tagaaacagt gctcattcca 535861 aacagtgtat ctgatggagg ggtgacgggt cttagcatcg ttggttcaca gctattcaac 535921 ttgccgctgg ggattttgat tgctgtgatc aacattccat ttgtctggtt aggatataag 535981 caaattggga aaagctttgc attattatca attatcggaa tcgtatcgct tgccgcgggg 536041 acaagctttt tccaccacac acccgctatc atagaaggag ataccctgtt aattaccgtt 536101 gtcggcggga ttatccttgg attcggaatg gggctggcgc tgcgtaatgg cggcgcatta 536161 gatggaattg acatgcttgc tgtgctgcta tcccgaaaac tgccattcgg aacgagcgat 536221 ctcattctat tcttaaacct atttgtgttt atttttgttt ccacagtatt tggcttacaa 536281 ggggcattgc tttcagtcat tgcttactac attgcatcca aagtgattca tgttgtggag 536341 gaaggcttaa gcggctctaa aacctttcaa attattacaa cccaacctga attaatggta 536401 gagacaatac gtgatcaatt aggccgaagc gccacatata aagaagctta cgggggtttt 536461 tcccacgaga aatttaaaga aatcacatgt gtcatcaacc gtttagaaga aaccaaacta 536521 aaggaaatta ttaatgatat tgataaaact gcctttgtta ccgtgtatga tgtagctgaa 536581 gtgaagggca gcaattttag aaatcttaat catcactaaa aaatagaatg acctttttaa 536641 ccgtaactga catgccgcgg gtaatttaat caaaaacact tttttgaggc ttgtgggtga 536701 ataaccggtg aaggtctgaa tcacagaaat accaagggcg tcaaaaccct tggtattttt 536761 tctggttatt agattttatc ttcagcttta cgtgctgctt cgagcttatc aatcctgtct 536821 ttatattttt ctccccagtc cttcatgtgc aggataacag gttctaatgt tcttccaaac 536881 tcagttaaag agtattcgac ttttggaggg acctgtttat aaacctcgcg gtgaatcacg 536941 ccatcccgtt ccaattctct taattgtagc gtgagcatac gctgggtaat ttttgggtat 537001 agttttcgaa actcattaaa cctcttttta ccgtcaatga gatgataaag aagaatgcct 537061 ttccacttac ctccgatgat atctaatgtt gtctccaccg gacatccttc aaagtcatca 537121 gaagaataat caatgccgag tttacgattt ctcaagctgt tcactcctaa tagtatactt 537181 tttgatacta tatacattca atgtgcgtac tttttatatt ttaatataca tcatataatg 537241 atgtcacatc taaggaatga aaggaatgga tcatatgaaa acactcgtac tcgttgtaca 537301 tccgaatata gaatcctctc gtatcaataa aaagtggaaa gaagccgttt taagtgaacc 537361 agatgtaact gtccatgatc tttatgaaaa atatcgcgat caaccaattg atgtggaatt 537421 tgaacaacag cagctcctgg cccatgaccg tatcgttttt cagtttccat tatactggta 537481 cagcagccca ccgcttttaa aacagtggtt tgatgaagtg tttacgtttg gctgggctca 537541 tggtcccggc ggaaataaat tgaaggggaa agagtgggta actgccatgt ccatcggttc 537601 acctgaacac tcttatcaag ccggcggata taacttgttt tcgataagcg agctgacaaa 537661 accgttccaa gcatctgccc atttagtagg catgacctat ctgccttcct ttgccgaata 537721 tcgcgccaat acaatcagtg accaagaaat tgccgaaagt gcgaatcggt atgtaaagca 537781 tattacaaat atagaattaa acccgaaggt tcgcctgcaa aggtatttga aacagctgga 537841 gagtgtcgat ttaacataaa gattgatttt tgaaaatcct gtactcacca agcaggattt 537901 tttcttgttc agcagaggga ttttaacata tagcaaaaaa agaagaagcc accaaaaata 537961 agctatttgc ttggtcctga ctgcttattt ttggtgaaat acttatttct ctgtgatgaa 538021 ataaagcaaa gcgatgaccg gaaaagcgat tccaatccat aatgctgtac tccatccgcc 538081 tgaggcatat gcccatcctc caattgatga ccctatcgca ccgcctagaa agaagatcgc 538141 catgaataat ccgtttaatc gactgcgaat ttcaggcgcc aacgaaaaaa tagcacgttg 538201 actgagcaca aggtttgcag atacacccat atctaacaga atagcagcgg ccactagaac 538261 tgttataccg acgggggagc tgctctgaat catgagcggc agtaataaag agacaacgac 538321 aacaccgaga gcgattccag tggcaagcct ggttaagcct cgatcagcca ggcggccgcc 538381 tattggtgca gtgactgcac ccgcaatgcc caccaatgcg tagagtgcta ttgccttctg 538441 agaaaaatga aaatcaggac cggacaataa taaaggaaca gttgtccaga acaagctgaa 538501 agctccaaat acaaacgcat gatagatggc acggcggcgt aagactggag tcgtgcgcag 538561 cagcttccac attgaaccga gtaaggcagt atagtttgta tttgctgttg gttttctggc 538621 aggaagcact tttgataata cgatggccag gataacactt accacggcgg acaaagcgaa 538681 tattgcattc cacccccaga tatcagcgac tagactagat atcggacggg aaagcataat 538741 accgagtaat aagccgctca tgacattgcc aacaacccgg ccgcgtgcag cgtctgatgc 538801 aaggtatgat gcaaatggaa caagcacttg ggctgcgatt gatcccaatc cgacgaaaaa 538861 cgcagctgct aaaaacagtg ttccatgctt cacaaatgct gttagtgtca aagccgctgc 538921 gcttagaagg agcgatacaa caataagttt tttgttttcg ataatatctc ctaaagggac 538981 aaggaatagt aagccggcaa cgtatccgat ttgggtgagt gtgacaatca atccagcacc 539041 gcttggagaa agtccaattg ccttactaat taatccgacc aagggttgtg catagtaaag 539101 attagcaaca atgataccgc atgcagttgc gagaagaagg gttaaactgg gtgaaatcct 539161 ctgacctgct tgtttgtttc cattagccat atgaatgaac tcctttttaa gtggtttttt 539221 gagtgtaatc atgacttctc acaagtgatt ttataaactg aacgttcagt ttcgtcgatt 539281 aataaaaata atatactaaa cgttcagttt tgtaaatgga tttctgtttt ctttttttat 539341 tcaatttaag tatactgaac gtatagttta tattgcggga aggaatgatt tatgtgcaga 539401 gtaaacgagg gcggccgcgt gatgaaggaa cgcataaggc gattctctct gcagcctatg 539461 acctattgct ggaaaaaggc ttcgatgcgg tgacagtcga taaaattgcc gagcgtgcga 539521 aagtgagtaa agcaacgatt tataaatggt ggtctaacaa ggctgccgtt atcatggaca 539581 gctttctttc gaccgcgacg gacaggctgc ctgtgcctga tacagggtcg tcagtacaag 539641 atatagtaac ccacgccacg aatttagcta ggtttttgac aagccgggaa ggaaccgtta 539701 ttaaggaatt aataggtgca gggcagttgg atgaaaaatt ggcagaagaa tatcgcacgc 539761 gatttttcca gcctcgccgc ctccaagcga aaggccttct agaaaaggga attcagaaag 539821 gtgaattgag agagaatctt gatattgaag taagcataga tctcatttac ggaccaattt 539881 tctatcgtct gcttataaca ggggatgagg tgaatgattc ctatgtgcgt gatttggtga 539941 tgaatgcgtt taagggagtt caagctacct ctgctacaga gagtatgtag ctgataagaa 540001 ctgcaaaagc tgcggattat atgacaaatt ggttccatcg tacagtgaaa tataagattt 540061 ttgttgctga gcggaatcat cgagggaaaa gttctcttat cggatgtcga aaaagaagtc 540121 attcaatcgt gaatacataa catcatatta ttacattcct tttcatcgat tggaacaagg 540181 gttctatact tcaatggaat accgcaaagt tggagtattt aaacaacagg ggaaaatcga 540241 tggccattat gtaggtgtca tggcaatgga aaaaatactt gcaatgtaaa caggcctcta 540301 aagagacctg ttttttaata tccagatgat tgtctagttt cagcttgggc tctatgacca 540361 ctcccataac tgaaatagtc taatatttat accagaaggg attgtttata taaataaaag 540421 tttatataat gacgggggcg ctaaggaaac gcggggagcg actcaggttt tcgtttcaaa 540481 gttttgatcc ttaagatata cggagcgcta catatggaaa cgtaaagggg aatgtataat 540541 catttggcgt gtatataacg atttgcttat atattgattt gggaaggagg agctcatatg 540601 acgattgatg ttgcggcgat gactcgttgt ttgaaaacac ttagtgatca aactaggctt 540661 atcatgatga gattatttct tgaacaagaa tattgtgtct gtcaattggt tgatatgttc 540721 gaaatgagcc agcccgccat aagccagcat ttgcggaaat taaaaaacgc aggttttgtg 540781 aatgaggaca gaagaggcca atggcgttat tattcaataa atggttcctg tcctgagttt 540841 gatacattgc aattgatctt acatcaaatt gatcaagagg atgaattgtt aaaccatatc 540901 aaacaaaaga aaactcaagc gtgttgccag taaggaggca ttagattgac atcaatgatt 540961 ttggcagtat tcatcttttt attaactcta gtattggtca tatggcagcc gaaaaattta 541021 tctatagggt ggtcagcctg tggaggcgca gttttagctc taatagcagg tgttgtcaat 541081 tttcatgatg tgttaactgt gacagggatt gtttggaatg cgaccttggc ttttgtggcc 541141 atcatactga tatcgttaat tcttgataat atcggtttct ttgaatgggc agcgcttcat 541201 atggctaagg ctgcaaaagg atacggtgtg cggatgttcg tttatgtatc tctattagga 541261 gctatcgtcg ccgcgttatt tgcaaatgac ggtgcagctc ttatattgac accaatcgta 541321 ttagcgatgg tcagagcatt acattttaat gaaaaattag tttttccttt tatcattgcc 541381 agcggattta ttgcggatac cacttcgctt ccttttgtag taagcaattt ggtcaacatt 541441 gtttcagcgg actattttca tattacgttt attgattatg catccagaat ggttgtcccg 541501 tacctgtttt cgctgctggc gagcatcatt gtactttacc ttttctttag aaaaagcata 541561 ccaaaacgct atgatctgac tgaggttaaa aaacctgttg aagcaattaa agatcaaaac 541621 atgttcagac tgtcatggta tatcttaggg ctgctgttaa ttggatattt tgcaagtgaa 541681 tttttttcta tccctgtatc agtggtagcg ggcagcattg caatcatttt cttaatcgct 541741 gcgcaaaaga gtccggccgt ccatacaaag aaagtggtga aagaggcgcc atgggctatc 541801 gtattctttt caattggcat gtacgttgtt gtgtatggtg tccgaaatgc cggattaacg 541861 gatgtccttt cagatgtgat tcaagccgca gctgatcaag gattgtttgc tgggacaatt 541921 ggaatgggct ttattgcggc gattctttct tccattatga ataacttgcc gactgttatg 541981 attgacgcat tggccattgc cggtacagat acacatggga tgatgagaga agcgcttatt 542041 tatgcaaatg tgatcggttc agatttaggg cctaaaataa caccgattgg ttccttagcg 542101 acattattat ggcttcatgt tctttcgcac aaaggtatga agatttcctg gggcacgtat 542161 tttaaaacag gaattatcct cacgataccc actttattga tcacacttgt cggcctgtat 542221 atttggctgc tgataatcca ttcttgtttc taaaaggaca aggtcactat atcaaggaaa 542281 acaatgcact ggtaactctt gccgcagcca aatggctgaa gggtggggga gaaaatacct 542341 tggggctaag tggaatgtgt acagcgcagg aatcgaagct caaggatgac atcgagtgct 542401 gtcaaagcaa tgaaagaagc agggattgat atttcaaatc aaacatcgga gaaatttgat 542461 gatccggcaa aagcacacgg aacagaagaa gtgtttccaa agggtccgtg atgaaattgg 542521 tgaccgttta aaacagtttg ctgtaactgg ggaataaaga atcgatatat tcagcgtttt 542581 cttgggttat ataatacaat gtgttgttca acaggtgtct gcgagctgag tgcagacacc 542641 tgtttttgtt tttatttgtc tgagattcgt aacagggaag ttatttagct ggtgacagag 542701 gaaaattgat ttgtgaacag aatcatgaag gagacggtgt tttaaaggag ttgtctgttt 542761 tgcaggaatt aacaaaaaaa aaatacagta gcttaaaaac aatgtttgat gacaaatatt 542821 gtcccacatt tgtctattca atattagacc aaaccattcc gggagctgtt tatgcagatg 542881 atcaaacctt tcctaaatcg ttttttatag gaactgaatc aggcatttat tttattgcgg 542941 gagaccaagg gaatcgggat tttcatgatt tcattgcagg atattatgaa gaacaagtga 543001 aatcatcaaa acgatttacc ttgttttctt ccagtgatac atgggatagc gtactgaaac 543061 ccatactgaa agatgactta aaccaaatga gaagagctgc attttcttat caaccaaaat 543121 ctttcaaaaa gactttgcaa ctgccaaagg ggcttgtatt gaaaagaatt gacgaagaca 543181 tcatttcaca tagcacagcg tttaacagcg cgtattatga ggagtattgg aattctgtct 543241 cacagtttgc ttcaaaaggt tttggatttg ccgtattaca tggcaatcac gtagtaagtg 543301 agtgtacctc tatattttta gggcataatc gagcggaaat ggatatctat acacttgaag 543361 aatatagagg actggggtta gcttattgcg tagcaaatag gtttatagcg ttttgtatgg 543421 aaaatgggat tgttcctagc tgggattgtg atatttgcaa caattcgtcc attgcattag 543481 cagctaaact agggtttaag acggtaacgg aatacactat ttactactct ggctaacctt 543541 aatgaaagaa ccttaaaagg agataccaac cgatgttggt atcttttttg ttttagagtt 543601 tttttaccct tttagcagaa aaatgggtga tgaaaatctt attcatttta tttactttta 543661 ggtaggtaaa acataccccg ccaactgtaa ccactccgcc tagcagagag agcagtgtgg 543721 gtatctcgcc gatccagagc caagatatga tcaaggctaa agccggtgta acataaagtg 543781 aaagggttgc ttctgaagca ccgacgaatg aagtgacata tgctagtgcg aagtaaggaa 543841 taaccgtcgg caataatcct aagtaaacga tagacaaagt tgcgcttatt gaagcgttca 543901 tcatctcttc gcctaagcct ggcagaaaca caagcatagg tattgttccg ccccaaatgg 543961 tgaatgtaac gaatggaata aaaccatatt tttttatata gcgggcttga aaaacgaaat 544021 aaatactctc cgaaaatgct gccagcagga tgaccaagat accgctcatt gaatatgtaa 544081 agtctcccgc cccaaatgca atcaataata cacccaataa actgatcata gagccaagcc 544141 atttcgtaaa tccaaaatgc tctttataaa acaggcggga tagcatggct gagaagatcg 544201 gtgccgtagt aacgagtaag cttgcaactc cggcactaac tgttttttca ccgatgttca 544261 gcaaaatgtg atagaatgca aatcctaaaa accctaaaag aaaaatggca ggaatgtctt 544321 tcaagtcggg taggcgcatc tgagtcaaaa cagcaaaaag caataatgcc atagagccga 544381 ttaacaaacg aaataaagca aggtgttctg gcgtgtaccc ttcaagtcct gcgcgaattc 544441 ccggaaaagc agatgcccat aaaccaatca tgagactatg agatatcatt atttgaactg 544501 ttttctttcg cattcctctc actcctcttt acaaaaacca accagttatt taatgtgttt 544561 ctatactaat aaagatttga tgatatggct tcaaccagtt caatagattt tgacccaacc 544621 aatttatttt aaggagaccg attctatgag ctttccagaa gaaaaaaaga tgaaaaagct 544681 ccctaagtac agacaaatcg ttcattttat taaagagaaa ataggaaatg gagagtggcc 544741 gattggaagc aagattccaa gccagcgcac gcttgcaaaa gattttcagg taaatcggag 544801 cacagtgatt acagcgttag aggaattgat ggccgatggg ctaatagaag gcacaatggg 544861 gaaaggcaca gttgttatca acaacacatg gacactgatg gctaagaatt ctgctcccga 544921 ttgggatcaa tatgtcacct ctggcattca gatgccaagc cgaaaaatcg ttcaagagat 544981 aaatcaatca gaatcaaata cagaccttat acagctcagt aaaggtgaac tttcagctga 545041 gatttttcct ttggctgtta tgaaagagat gatggggaag gtatctcaac acatggaggc 545101 attcggatat gaagaaccaa aaggttactt acctttgagg gaggcattaa gcaactattt 545161 aaaaaccatt ggaatcaacg tctcatcttc ttccattctg attgtctcag gagcgttgca 545221 agccttgcag ctgatatcaa tggggctgtt acaaagagga tcaaccgttt atcttgatca 545281 gccctcctac ctttattcat tacacgtatt tcaatcagct ggtatgaagc tgactggact 545341 tcctatggat aatgaaggac ttttgcctga aaatgttcat ttaacaagag gagagcgggg 545401 aagggctatc ttatatacaa atccatgttt tcacaatccg actggtattc ttatgtctaa 545461 aaagcgacgg gaagaaatcc tagcagtaag tgagaataca cagcttccta ttattgaaga 545521 tgacatttat cgtgagttat ggatcgatga aattccgcca tatcctatta aaacaattga 545581 taaaaatgga cacgtactgt acataggaag tttatcgaaa acattaagcc caggtttgag 545641 gattggatgg atcgtcggac cggaaccggt gattgaacgt ttatctgaca ttaaaatgca 545701 aacagattac ggatccagtt cgctatccca gagagtagcg gcagagtggt ttacttccgg 545761 ccactaccag cagcatgtag aaaaggttag gcagcaatta aaggtgagaa gagaattggc 545821 cttgagtgct ttagaaactc atttgaaaga agtggcgaca tggaatatcc caaaaggagg 545881 gttttttgtc tggataaaaa tattgccttc catatcaatg aaattacttt atactaaagc 545941 cttatcaaaa gggattctga tcaatctcgg cagtatctat gctcaggaaa aagggaatta 546001 tattcgctta tcatatgctt atgcatctct tgaagacctt caaaagggga tttatgagtt 546061 gggtttaatg attaaagaat tggcaagcag gtaactttta tatccttaaa tggatgtttc 546121 actaaaaaag agatcaagcc taatgatcgc ttgatctgat aataacaagg gttactagaa 546181 tagaccaaat catggttcgg tcttaaaata atcatgtctc tgaacgaaaa gtctttccga 546241 cttctcttcc taaaccaaag tagtgtctga aattatagat aagcgggctc catttggaag 546301 ggttgatatg gttttcgtcc agaatgatac tttcctcggc atgaaaatgt agtgcctgcg 546361 tctctacaat tgcgaatgac gattcatatt ctggaagccg aatgtgtttc acttcggctt 546421 cgatttggat agggcattct ttaattcgtg ttggtgatac tgtttttgat tgtaaaggcg 546481 ttaaccctgc tgcctcgtat ttttcttttt tatatgtaaa tccgatctgc ttctttaaag 546541 gcggtatact cttttttccg ctataagatg aaattctttc aacgttttcc cataaatccg 546601 ggccaggcaa gtttatgaca cactctttgt gtctttccaa attgtcgatg gcttttcctc 546661 ccagtcctac tccaaggatt atataatgtc caagagccca agaagaagac ataggactaa 546721 tattagtggt tccatcctca ttcaatgtgg ttagaagaaa tgtcgaggta ccataataca 546781 tgatcttggg tttgatttcc ttaaatcgac gagtgtcttg ttttttgatg tccaacgttt 546841 tttcctcctt gtcacgctta catttatatt gtaaaggatt aacatttcaa ctatcatcga 546901 aatatgaatg taaggaggaa aatcatgaat cctaatattg caaaaatctc ttcgttgcta 546961 tcagatccct cgcgttcttc cattcttctc agtctgatgg atggaaggat acaccctgcg 547021 ggagagcttg catatctcgc taacattaaa cctcaaactg caagttttca cctgaataaa 547081 ttgcttgaag caaagctgat tagcgtagag aagcatggga gacatcggta ttacagattg 547141 gctgactcag atgctgcaaa tgtgatcgaa caattgcttc atattgcgcc taaagcaaaa 547201 gtcaaatctt taaaagagtc aaaagagaaa aaggacttgc atttcgcccg gacctgttat 547261 gatcatttgg caggttatgt gggcgtgcaa atggcacatt cactagttga gcaggggatg 547321 ttaaaaaaag ttgatttaaa ctttgaggtg acttcagagg gtgctttatt cttttcgaag 547381 ttaggcatca atgaagagca acaacggaat aagaggagag cctttgcccg ctgctgtttg 547441 gattggagtg aacggcagca tcatattgca ggagcattag gaaacgccct attggtgcgc 547501 atgttagaag aagaatggat cgttcgtatg cctaaaacga gagcgattag gattacacaa 547561 agcgggaaaa tcgcgtttga aaagcaccta aacgtgaaga tttaggattt tgaagcggaa 547621 acatcagatg atgaggcacg atatctagga ggagtaagat ttgttctaat cttactcctt 547681 cttcttattt tgaagcagct cgattcccca ttgcaataga gatgcggttc caactgttta 547741 tttgattaat gatcagaaca aggtcaacat attgttcctc atcataatgt tcccgcaccc 547801 gatgatatag ctcatcagga acccttttag atggaatgag cgtgatgtgt tcagatagtt 547861 cgagagccgc tttctcttca ggtgagtaaa aatcacattc attccaagca tgtaaacagt 547921 aaattcgctg ttcagtttct cccattttgc gggcatcgga cgtatgcata tctatgcaga 547981 aggcacagcc gttcatttga gagactctga ttttgattag ttctctcgtc gttcggttaa 548041 ttgaggattg tttcgtgtat ttctccatat ccatcatgat tttcatacct tcaggtgcaa 548101 tctcatagta ggacactctt tgactcataa agcaagactc ctttccatag aatacctaga 548161 ttgtatcccg gtattgatca ttttaccaat gtgcggtttg aatgacagct gtttcagcgt 548221 cttttggaaa gaagcttctt tgaataaaaa taagggtagc cagcaatgat gagtggagct 548281 gctaatgcaa gcagtatcca tgagcctgat tggctgtctc tagtgactct aatgaatata 548341 taagtaccga tcagaaaata taataaagca cctagaaacc aatacatgtt cattcctctt 548401 tttccttgct ttttggttgc gcatttttgt ctgtcatatg gcttaatcga tcagggttct 548461 gattttttaa taccttttcg gtccggattc cttttctctt taatgataaa attgtgagat 548521 caatcgattt caatgatgat cattccttca atgaatagta agttccttat gattttaaag 548581 gtaaatttga aaagataaaa cgtacataga ggcagaacgt tcatgtacgt ttgggcaatg 548641 atcacttgtt ggaaactcta atgtttccct gcacctgata ttgttgtgtt ccttctcttc 548701 ctataaaatg attggataca tgtatgtttg cacgttgaaa tatgggttcg attttcatga 548761 atctctattc ggtgaaacag gtaaaggaag tggataaggt ttgcttataa ggaatccttt 548821 taaagataaa tattactcac atgataggcg ggcattaaac atgcttgcac tcagagtgcc 548881 gggcctggct tttattctca tgatctatat agcctctatc gtgctgcaat ttgtttctgg 548941 gggctggtcc attttattgc tttatgcgtt taccatatta atcgccattt ttgctttgct 549001 tcattggcac tcatatcgct gggttaagaa aagagtgatt ctgtatttcg cggtacaagg 549061 tttgatcacc tttgcacttg ctaatctcat gactggcttc tttatacttg tgattatcgg 549121 cctttatgca tttttaattg gacaaattat aggaatggca gacagaagaa ggacttttct 549181 cattctttat ctattgctgc tgctggtcat aaattcggcg tatcaccttc ataaaggtga 549241 agttttgcat tttattgtta ttgctgcgcc gatcatgatt gtcatcatca cttatgccgc 549301 aacatttttt gcccaagtcg atgaaaaaat aaaagctcaa ttgactcttg aaaggctgga 549361 gctggctcat cagcaggtag aacagctgac gctgcagaac gaaagacagc ggatggcccg 549421 agacttacac gatacgcttg ctcaaggtct tgtcagttta aatatgcagc tggatgcgat 549481 tcatgttcat ctcgccaaag gcaacacaga gagagcgaag gaaatcatac aacaatcgat 549541 gaaaagagtg aaaagcacaa tagctgatgc acgttcagct attgacgatc tccgcagcaa 549601 atcagaagaa atcggtgttt taaaagaaag aattacctcg ctaatggatc attttataga 549661 gtcgacaggc atggcttgtt tattagatta cagattgcat caggtgctgg atgtgcgtac 549721 agctgaaaac tgttattaca tcattggaga atgcatgacg aatgcggcaa agcatgctga 549781 ggcgaaaaca atctggatat ccatttggga tgatgaaaag ggaaggctcc atttaacagt 549841 taaggataac ggcaagggat ttgatgttga aaaaggaaag aaaaagagag gacattatgg 549901 gcttcttggc atacaagaac gcgtcagggc aataaatggc caattcaata tcaagagtac 549961 aaaattgaaa ggaacacaaa ttgagatcac tgtaccaatt cagggagaga tgcaagatga 550021 ataaggtttt aatcgttgat gaccatcttg tcgtgaggga aggtctgaag cttttaattg 550081 aaacgaatga tcaatacacc attataggag aggcggaaaa tggaaaagta gcagtccgtc 550141 ttgcagatga attagaaccg gatatcattc tgatggattt gtatatgccg gagatgagcg 550201 ggttagaggc cattaaacaa ataaaagaaa aacacgatac ccccatcatt attttgacta 550261 catataatga agatcactta atgatcgaag ggattgaatt aggagcgaaa ggatatctgt 550321 taaaagatac gagttcagaa accctttttc acacaatgga tgcagccatc agaggaaatg 550381 tgctattgca gcctgatatc cttaaacgtc tgcaagaaat ccaatttgag cggatgaaaa 550441 agcagcgcaa tgagacgcag ctgacagaaa aggaagtcat tgttctaaaa gcaattgcta 550501 aaggtcttaa aagcaaagcg attgcctttg atttgggcgt ctctgagcga acagtaaagt 550561 ccagattaac gtccatttac aataaattag gcgcgaattc aagaactgag gcagtaacga 550621 ttgccatgca aaaaggtatt ctgacaatag acaactaaac tgcatatttg aaaattgccc 550681 aaacgtacat gcccgaatgt acgttttttt catttcattg tcaactacaa tgagaaagaa 550741 tgtgatcaag caatgtgttg aaaggagatt atcatgtcaa aaatgttata tacattagga 550801 ggatgggttg ctcgcaatcg cataaaagca atatgtgcgt ggatcgttgt gttagttgct 550861 gcgataggcc ttgcagtgac cttgaaacca agtttttctg aggatatgtc catacctgac 550921 acaccttcgg aaaaagcgat ggatgtgatt caaaaagaat ttcctcatgg tcctgataaa 550981 gggagcatac gggttatttt cggtgctggt gatggggaga aacttactgg gaagccagca 551041 aaaaaagcaa tagaagatac gttcaaagaa atcagtaaag atgattctgt tgactcgatt 551101 gcaagtcctt ttgtgacagg gacaatcgcg aaagatggca cagttgccta tgctgatatc 551161 cagtataaat catcagcaga tgatataaag gattactcta tcaaacactt aaaagacagt 551221 ttgaaaatgg ctgatgatga aggattgcaa actgagctaa gcggagatgt accgggagcg 551281 gagatggaga taggcggtgt ctctgaaatt gtcggcatta tcttggcttt tgtcgtttta 551341 gccattacat tcggttcttt attaatagca ggtttgccga ttttaactgc actgattggt 551401 ttaggtgtaa gtattggact ggttttgatt gggacacaag tatttgatat tgcttctgtc 551461 agtctttcat tagccggaat gattggcctt gctgttggta ttgattatgc tttatttatt 551521 tttacgaaac accgccagtt tttaggcgaa ggcatacaaa agaatgaatc aattgcgaga 551581 gccgtgggaa cagcgggaag tgcagtggtt tttgccggac ttactgttat cgttgcactt 551641 tgcggattaa ctgtcgttaa cattcctttt atgtctgcga tggggctgac agcagggctt 551701 agtgtactga tggctgtttt ggcttccatc acacttgtgc ctgcggtctt atcgattgca 551761 gggaagcgga tgattccgaa atcaaacaag aaaatagaaa aacaaagcac tgaaacaaat 551821 gtctggggac gctttgtcac caaaaatcct atcatgctaa gtgtatgcag cattctgatt 551881 ttgatcgtca ttagtatccc atctatgcat ttggaactgg gcttgcctga tgctgggatg 551941 aaagctaagg ataatccgga tcgccgggca tatgacttgc ttgccgaagg ctttggagaa 552001 ggatttaatg gccaattaac aatcgtagcg gatgccacaa atgctacaga aaataaggcg 552061 gaggctttcg cagatgcagt gaaagaaata aagggcttag accatgtagc aagtgtcact 552121 cctgcaatgc ctaataaaga agggaacttt gccatcatta cggtcgttcc tgaaacaggt 552181 ccaaatgatg tcacaacgaa agatttggta catgatgtac gcagtttatc agataaaaac 552241 ggagtagatt tgcttgttac tggatcaact gcagtgaata ttgacatttc agatcgcctg 552301 aatgatgcga taccggtgtt tgctgtactt attgttggct ttgcgtttgt attgctgacc 552361 atcgttttcc gttcgctgct tgtgccgctt gttgctgttg caggtttcat gttgacgatg 552421 acagccactc ttggaatctg tgtatttgtc ttgcaagacg ggaatctcat cgactttttc 552481 aaaatacctg aaaaagggcc gatactcgcg ttcctgccga ttttatcgat tgggattctg 552541 ttcgggttag ccatggatta tcaagtattc cttgtcagca gaatgcgtga agaatatgta 552601 aaaacaaaca atccagtaca agccattcag gctggattaa aacacagtgg tcctgttgtt 552661 acagcagccg gcttgatcat gatcttcgtt tttgcaggat ttatctttgc aggcgaagct 552721 tctattaaag ccaatgggct ggctctttcc tttggtgtac tctttgatgc ctttattgta 552781 agaatgacac tgattccaag tgtcatgaag ctgatgggga atgcagcctg gtatttgccg 552841 aaatggttag acaagattat tccgaatgtg gatatagaag ggcatcaact gacaaaggaa 552901 atacagccgg aaatagatca tgaacaaaag aaacaaatca gtgtgtaata gaaaaagcag 552961 atcttttatg atctgctctt ttgcttatgg tagtatttag aagatgaagt cggcagttaa 553021 aaggagacgc ttatggcgcc atcactcatt ttcgatatgg atggaacttt gtttcatatt 553081 ggcagaagct gcatcatact agcaggcatc ccaggagaag tgacatgatt ttttgacttt 553141 gcattcacta cttgatgcca aggatcttga gaatccttct tgaaaataaa ggattttaca 553201 actgatcata taagaaacct aaagaaacaa gcacacaaaa ccagctgcgg gttttgtcca 553261 agaaaaatag agtccataag agggactcta ttttttgaag tgcccggcta gaagcatatt 553321 gcaggacttt atgaatgcaa atcactatct tataagccct taccgtgaaa tgcctgtttc 553381 tgcattgaaa aaacgcatta cacgttcatt tacgtaagtg ggttgttcca tcgataaaac 553441 atgtccggca tttttaatga cttccgcctc aatatctgga acgaatgaag aggctcggtg 553501 cagggctgag tggggatcat agatgacttc atgttcacca agtaataata ggataggaac 553561 tcttgctgaa cgtaattcct catcggtaaa aacatacgga aatccgtcgg cattaggatt 553621 tggatttctt gatccatcct gccacattac ccctgcctta aactgcttca caaaaatcgg 553681 gtgcagcaca ttctgatcat tcatcatcca atttaagaat gtttcaactc catttgacgc 553741 tgtaaggcca agagcgtatt tgtagaaatc gtgatgaaat ggcaaaaacg tttctgccgg 553801 actcagtata gctgcgcttt ttactctctc aggcatacgt aaaaggaaat tcatcgtatg 553861 gagaccgcca agcgaaagtc cgatcatgtg ggacttttcg atccccagat tgtcaaacac 553921 atcaagaagc caattggcgt aatccgttct tgtaccgctt acattctcag gaatactctt 553981 gtttttatca cctatgatat caactgcata agttctgtat ttactgctcc aatcggcgat 554041 gttgggatac cacatcgtcg agctgaataa tgctccgtgg agtaatacaa gcggcggggc 554101 atcctctggg ccgcttgcaa tcacatgtgt ttgaccaaaa cgagtagata tatagaatga 554161 tttacaacgg accggccaaa gactaaggct ttcattataa gtttgataat agcggatacc 554221 gttgtcactt aattcgggaa tactagatga atggtttgac atacaaatgc ccctcccaat 554281 tttgtttaaa tgaatgtgcc gtttcgtgat ggggaatctg attttgatat aacagacttt 554341 atttacaata taatacagtt gttattagac gtcaaatcca agatgaaaag gaaaaaaacg 554401 attgaaacag attattgaaa atcaatataa cagaatatta acctcctttg tggagccgct 554461 tcattaaaac cgcaatccaa atgcatgaat cacaaaaatc acaacaggag ggatcaggag 554521 ggaaggcagc agattcagtg ttttgaactt cttgattcca agaatgctta gacctgaact 554581 gaggatgagt atgcctccca caattgtgat ttcattaata aggtctgtat tgattgcgct 554641 ctccattact tgtgcaaata aatagatgga gccctgccag gaaaataata caagtgcggc 554701 agccgctatt ccaaaaccaa aagttgaagc gagcacaatg gaggtgatcc catctaacat 554761 cccgtttgtc agaaggtatg tataatctcc atgcaaagcg gcttcaacag ggcctaatat 554821 tgacagcgaa cctatacaaa ataataagac cgcagttgat aagccctctg ctaaattgct 554881 tttagaaaat ttgttcacca gcttgttgaa tcgtaattct aaattgatga tctggcctag 554941 caaacctcca atggctaaac tcacgatgaa tagaatgggg tatttactat caggcaaatg 555001 ctgtgtaatg gcgttgatcc ccagtgcgac cgcagcgaat cccattgcct gcatcaaaat 555061 atcctggtat tcatctttaa tgcctttttt gaatatcccc ccgattatgc ttcctgcaat 555121 gatcatcact gtgttaaaaa tcgttccaaa cataagcttt ctcctccaaa aatcattcct 555181 gcataaaaaa taaaccctct agttagtaga gagtcaaggg agatcaaaac atattcatga 555241 gattatttga tgggcagcag gatttcagtc acgtaattat ctaggttatt cgtaatgcca 555301 taatcaatga gtgtgatttc gattgagtcc cctgctacct cataatgatg ttctttcata 555361 tatgccagta attttttgta gtatggttcg gcttctggat gtgacccttt aaacctaatt 555421 tgcagatatt ctcttgaagg aaagatgatt tctgaagaag ttttttcatt ttcatcttca 555481 agaatcataa atatactgga atatttgtca aactgttttg ctttcacatt tgctgcagaa 555541 atggataaac caatcttgcc tatgaatata tcttcgttta cattcaggtg ggttctcaat 555601 tcagctaacg aatgttcgat atcatggccg agaacatatt catgctgcaa ataggccaca 555661 cgcattgcgg gaagtttgat ttttgaaatt tgatgtaacg gcatgttaac ggcatcttct 555721 atatgtgtga tgcgtcggga gatctttcgt tcaatgcgtt ccaattcttt cttcttgcga 555781 tcaatttcaa cctgctggct ttttagtaaa tgaagaagag tgtttgtatt ttgagagtta 555841 taaaaatcaa gaagcttatt gattggcagg cctagggccc tcaaatactt gatggtatcc 555901 agccgctcaa actgttgggt agaataatat ctatagttcg tttgctcatc tttatattcc 555961 ggtttcaaaa ggccgatttc atcataatac cgaagagcag agattttcac attgaataac 556021 tttgacactt ctccaatcga aaaaaattcc ttcattctaa caacctttct gtcctatgat 556081 tgatatacac acattatata gtacggcgag tactaaaggt aaagtttgca gcataaagaa 556141 aaaactcctt ctaaaaagga gcttttcatt cttcgaaata aggatttaca tggatgagca 556201 cttcttctac atctgaaaac tgtcttttga tttcatttcg aatttcgcgg gcaatgtcgt 556261 gtccctgctt aattgtcaaa tcatgatcca aagataaacg gacatcaagc aatttatagt 556321 ggccatgttc tcgcgcgcgg attctatcaa ttcgttttac ctgatcacat tgaaaaataa 556381 cagctttata ttcctctatc agctcgggat caacactctt ttccatgagc acatcaacag 556441 acggcctgat taattccatt gaaatcttaa aaatgaggta agcaacgatt gcactggcaa 556501 tggcatcggc gtacaacaga taggaccatc cacggctgtt tccgatgata gccaacagga 556561 cgccgataaa agcggcaaga gaggcaacga tatcgccttt atgatcgtac gcaatcgcta 556621 taatcgcttt gctgttccat tttttccctt gctttataga ataacgatat aagatttcct 556681 tagccacgta cgaaatcaga gccgcaaaca atgcgctgta ttggggaacg cttggccctt 556741 taacaaagga cagaatcgct tctatgagga tataaacgga tacgatcact aagataattc 556801 ctacaatcgc ctcactaatg acttcagctt ttccgtgacc aaaaggatgg tcttgatcgg 556861 gcggtttatt ggaaattccg atcactgcca agactgcaat cgaagcaacg acatctgccg 556921 cggaatgtat tccgtctgca aacacggctt cactatcgcc taccagccca aaaaagacct 556981 ttcctgccat taagatcaga ttggcgatca atgcaatcaa agcaactttt ctgcttattt 557041 gttctctttc acttgccatt ttttcctcct ataaaactgc acaaaaaaat aggagtgctc 557101 tatatacgct ctccgtatcc tttcctgtgt aatcactttg tttatcatac caattcaatt 557161 tcgagtgggt ctatagcaac gttgtttcct gtttactaat aaataaggtg acagaaaaaa 557221 agttggagct atgctaaaaa ggtcatacag caaacaaatg agttcttatg taacaacagt 557281 gatgattcgc tattaaaatg ctgccgtcag tgaaaaattt ccacctaatt ttcaaaaacc 557341 tattgacatg agaagatctg tattttacta ttatctcata ttcaagatat tttaatttga 557401 gatatttggt cggaaagatc agcgatcaag cgcaactcta agtgttcaat cgttgtcagt 557461 tcttttacac aatattcaat atgatttttt ataacataat atctcgaatt cgagataaaa 557521 gggagtgtag cgtaatggct gaatttactc atttagtcaa tgaaagacga tctgcaagca 557581 attttctttc aggtcatcca atcacaaaag aagatctcaa tgagatgttt gaattggttg 557641 cattggcacc atcggctttt aatttgcagc atacaaaata tgtgacggtt cttgaccagg 557701 acgtaaagga aaagctgaag caggccgcaa acggacaata taaagtggtt agctcttctg 557761 cggttctctt ggtattaggg gataagcagg catatcaaca agcggccgat atctatgaag 557821 gtttaaaggt attggggata ttaaataagc aagagtatga ccacatggtg caagacaccg 557881 tttcgtttta tgaaaacagg ggagaacaat ttaagagaga tgaggcgata aggaatgctt 557941 cactttctgc gatgatgttt atgctgagtg ctaaggaaaa aggctgggat acctgcccga 558001 tgatcggctt tgatgcggaa gccgtaaaac ggattttgaa catagacgac caatttgagg 558061 ttgtcatgat gattacgatt ggaaaagaaa aaacagagag cagaagaccg cgcggctacc 558121 ggaagcctgt gaatgagttt gttgagtata tgtaaaagga gcggataaaa atggctaaaa 558181 aaacgatggg aattcatcat attacagcga ttgtcggtca ccctcaagag aacacagatt 558241 tttacgcagg agtgcttggg cttcgtttgg tcaagcaaac tgtcaatttt gatgacccag 558301 gtacgtatca tctttatttt gggaatgaag gcgggaagcc gggaacaatc attaccttct 558361 ttccgtgggc cggagcccgc caaggcgtca ttggagacgg tcaagttggc gtgacttcgt 558421 atgtcgtgcc gaaaggggct atggcatttt gggaaaagag actagaaaag ttcaacgttc 558481 cctacaccaa aatcgagcgc tttggggaac aatatgtaga atttgatgat cctcatggac 558541 tgcacttaga aatcgtggaa agagaagaag gagaggctaa tacgtggact ttcggagaag 558601 taacgcccga tgttgccatt aaaggttttg ggggtgcaac cctattatca gagcagcctg 558661 acaaaaccgc tgacctttta gaaaacatca tggggctgga gcgagtcggc aaagaaggag 558721 acttcgttcg ttatcgttcc gccggtgata tcggaaatgt gattgacctt aagttaacgc 558781 ctattggccg cgggcaaatg ggggccggaa cggtgcatca catcgcttgg cgggctaacg 558841 atgatgaaga tcagttagat tggcaaagat atattgcttc ccacggatat ggtgtaactc 558901 ctgttcggga tagaaactac tttaatgcca tttacttcag ggaacacggg gaaatcctgt 558961 ttgaaatcgc aactgatccc ccaggctttg cacatgatga aacacaggaa acaatgggcg 559021 aaaaactgat gctgcctgtg caatatgaac cgcatcgcac acaaattgaa caagggctgc 559081 tgccgtttga agtaagagag ttagattgat ttgacacata aaaaataaag aaacatatat 559141 tcaattgatg attgctggat ggtactgtca gcaaagaatc agataaaatc aaagatgagg 559201 agagatacaa atggaagatg caggactgtt gcttattcgt ataatgattg gtgtggtgtt 559261 tttgttttat ggcacacaaa aattattcgg ctggtttggc ggatacggga ttaaaggaac 559321 cggacaatgg ttcgaatcaa ttggggtgaa accaggaaac gttgcggccg ctctatcagg 559381 tcttggggag ttagtaagcg gaattctatt tattttaggc gtattcctcc cgcttggagc 559441 tgctatcata acaatcatca tgttaggtgc tatcgtaaaa gtccatggag cgaaaggttt 559501 tgcgaatggc gccggaggtt ttgaatataa cctggtgctc attgcagttt ccataggggt 559561 tgcactcatc ggttcaggag cttacgcttt gcatttttaa tacgaaagta tgtaagaaca 559621 gttgctgctt gtcagtaact gttcttttat tttcacattt tcggcaagct tgcaggtact 559681 ctgcaaagca aaaaagcgga tatcataaat ataaatctgt atagtgaatg atacgtattg 559741 atgagcttgg tcatgaaaaa cagacctatt tgaaggagta aatggatgaa agagatgaca 559801 ggattacatt cattagtttc tatagaaaac tttatcaaac agcacaaatt cagttttatt 559861 tatatatcaa ggcctggctg tacagtatgt cacgcagttc tgccccagct cagaatagta 559921 ttggatcagt ttccaaacat caaattgggg catatcaatg ctgacgatgt agcagaggtc 559981 gccggcagat tttcagtttt caccgttcct gtgcttcttt tgttcattga tgggactgag 560041 tttctaagag aagcccgttt tgttcatttt gaacagcttg aacaaaagct gaaaagggtt 560101 tatcgattat atgaaggcga ataaaggaat aaggcaaaaa aagaactcaa atgagttctt 560161 tttttattct tcactaggcg aagaagggtt atcaacctgc ccttgatcac ttgtatcatt 560221 atcacaactt gctgaaataa taattgaatg agaaggagag taatctccta atgtgaaatt 560281 cactccgtaa tttttgctgt tcgcagtatg gctgttttgc aagttttgtc cgatatctgt 560341 attggcgttt tgtgtcattc catttatcgt gagatttgag atgttgattt gagatcgcat 560401 gcttcaaaaa ctcctttcac tcagaagtag ctgtcataaa ggacgctggc agtctattta 560461 cttctatgat attgcgtttt tatatcattg catcaacata atggtaaaaa taatagcgag 560521 tgaatgatca tcttttgaag atgatcaacc tatcagcaga aataaagccg cctgataaag 560581 aggcggcaga tcgttatatg tcatctatga atttgatgta tcgtttttcg tttgcctgaa 560641 ggataagata gtcgttttta atgatgagta ggagcctata gcagcgtagc cataaaacca 560701 gcccataaat acgccagaaa agaggctgtg tcgatggctt atgaaaacag aaatgacaag 560761 gcctgttatt aaggcaactg acggtacaaa agttttgggg attttcaata atattttgag 560821 gatttgggtt atcaatatga tgattggaac agctatcaca gcatcccaaa agttcgtgtg 560881 aataattgga aaagccatac ggcacctcat gaagtgttta tttcttaatt tttacgctaa 560941 aagcttggaa agcagctctt ggatcgcata tgttacattt tgggcttgat tggcggagct 561001 tgtttggctt aaagcattgg attcaaaaac caaacctgta ttactcccac cggaaccctc 561061 tgttgtttta gacacagaga acgggctgat ggaaactgca aatccgttat taaaaacgct 561121 gttcccggat atcgaatgaa tataaactgg gaatttcatc attcatctct cctctctgtt 561181 atgactgttt atacaatatg gtgtgtgagc agcagttgct taaacaaaac ggcaaaaact 561241 ttcagtaaga gacaaaaacc tgcaaaatgc cacaagcgcc ttttgttaat gcagcttttt 561301 agggacgttt tttttatttt ttttgccaac ttcatcaaaa atattctgat tgccagactg 561361 ggcttgtccg tccttattta tgaaatcggg gtgaatgagt tttttcagat ccctgactgt 561421 taaaggcttg gcgtcatcag ttaattctat tcctaattgc ccgtttgcct ctaatgtcgc 561481 aattttgaca tcttgtatag ccgtaacgcc gtgaagcctt agctgcattt caagctggtc 561541 agctgtaagt ctcatcttct ttaagttttc gatatgaagc tgtccgtttt caatgacgat 561601 ttttgctttt ccggttaaca tcttttcaat ggtgttcgat ttcatttgga tccattccat 561661 aacgatgagt gtgcttgtga aaattgccgc tgcaattaat gttttgaaga ggctgtactc 561721 gatgattggc tgaacgataa tagttccgat cgaaatcatg acaaccgttt gagtcgacgt 561781 catttgtgcg attgatttcc ttcctgaaat tctcagcaaa atgaccccgg ctacaatgag 561841 aacaagagat tcccaagtga aattcatgct accacctgac caatgatgaa ttagatttgt 561901 catgggattg gcttttcttc cggccaatcg caatttaata tatccgaaag gcagtcggtt 561961 cattctgtcc tgaaccgaac aatatttttg gtatagatgg atatattaag ccaaacaatg 562021 atagcaacag gagttttttg gccgaaacaa tctgggaagc ggggagcgcc ataacatgat 562081 tgaacttgaa gttgtcatta gaacggttgc cagctttggc ttgctgttaa tcgcagaacg 562141 aattttaggc aaacagacaa tctctcaaat gacgattttt gattttattg cggcgatcac 562201 actaggggcg attgctgccg gattagctta caatacttca ataaaaccgc acaatatggc 562261 catttcgttt agtatttttg tgctaaccat ttttctaatt tcgtttctgt cgataaagaa 562321 caggaagctg aggaaatttt ttgccggaga tccaacagtg ctgattcaaa acgggaagat 562381 acttgaatca aatatgagga aaatgcgtta cacacttgat tatttaaatc agcaattacg 562441 ggaaaaagaa atatttaata tcgaagaagt tctttttgcc attcttgaaa cgaatggtca 562501 gctgactgtg ttaagaaaac cgcaattccg gcatgtgacc aaacaggatt taatgattgc 562561 ggtaaaccaa gaacaaaggc ttccgataga acttattatg gacggagaaa tcattgagaa 562621 taatttaaag cagaatcgtt tgacggaatc ctggcttttg gaagaattgc gaaaaagaga 562681 cataaaggtg aaagagaccg tgtacgcagt gctgctgggt aatggggata tttatgtgga 562741 tcaatataaa gaccatatat cagtccctat ggataaggaa tgaaggaaca atcaatctta 562801 aagcccctta ttgaacgcaa cggtttcaac ttgtcttggg tacgaaatat gcagaagccc 562861 gtttaacagc tgaatctgta acaaatgagt ttcagcggct tcgggaagct gaatgattcg 562921 ctcaatttct ccgtaatacc gttcacgcag cacttccatt tcggctggaa aaacaggcgt 562981 gatcgttcct ttgatcagca gctgggtttt agacagtaaa cggatcgtta attcttcctc 563041 atacacaccg ggcatttcca caatgataaa attatattcc tcatcttgat aaaagtcgta 563101 aacaaacgta gaagcttcgg aatcaaaaaa atgttccggg gctttatatt tgagcacatt 563161 tgtccaaaag tcactttgtt tatattcatt cgtaatctca agccactttc gaattttttc 563221 gaaatccata tgagattctc cttaaatttg atttgaaatc ggcgcagaag ggtttccgat 563281 ttggtcttgg tcactaacgt ctgaatcaat atttccagtg tttaaaagtg aagacgtagg 563341 cgaaagatcc cctaaggaaa agtttgctcc aaaatatttg ctgttcgcag tatggctgtt 563401 gtgcacagtc ggaccgacat ctatatttcc gttttgcgtg acgccgttga tcttaatatt 563461 tgcgatatta atttgatatg gcatagacga aaccccttta atctaaaatt ggcggtggtg 563521 caatcggagg agcattaacg ttggatgtat cagagttgcc gatagatgtc tggtcattta 563581 catcaggatc gtttaagaag ttttccatta cggattctgt aggtgatgta tcaccgaaag 563641 aagagttggt cccttgagat ttttgattgt tggtagggct gttataagca gcttcgccta 563701 ttgtaattga accattgccc gaaatactgt tgatcttcaa ataatatagg ttgattactg 563761 tagacggcat cccatcacac ccttccatct ttctgtacag tacattatgc gccgctgcac 563821 ccaattgttc cttgcattta cgggcaaaac tctatctggc cccggagtga tgctcaatta 563881 tcagtgaatg aaaagccatt gatataggaa tcaatgaatt gattcagtta ttcgaaatgc 563941 atgagacctt ttaataaagg aagctggcaa acaggatcag tttgaaataa ttgacaatga 564001 agctaatgcc atgaaataat actcgtgagt aacattactc gtgggtatta tttttggggt 564061 ggtcctagtt gaaaagtaaa ggagtagaaa gccgaaaacg attacttaaa gctgccgcta 564121 atgaattttc ggttcgggga ttccatgacg cgaaggtaag tgaaattgtg aaaaaagctg 564181 ggttcacgca gccttcattt tacctgtact ttcaaagcaa agaagccatc tttgccgagt 564241 taataaccga ttttcactct cgagtcagaa agctgacaga gtcacttctt ctggaaaacg 564301 gattaaacac ggaggatgtg tcaaaacggg tactgctagc tgtagagact gtttttcaat 564361 ttttggatga ggacaaggat ttaaccaaga tcggcttttt tctcaacccg gaagcaaaac 564421 aaatgaaaaa agacttggcg atggttttga aagagaactt agaagcagaa cagcggcttg 564481 gctattttca ctctgaactg gatatggaaa ctgtcgctga gtgtttggtc ggcatgattg 564541 aacatttaac cgaatcattt ttgttaaccg gaatcaaaga tccggcaagc ctcgcagcag 564601 aggttgtgaa tcttttaatt tacgggatgc ttccgaaagg gaatgatgta agatgatatc 564661 tattatgatg aaagtcagtt tggcagtttt tatgcttgcg ggaggcatca taaaggtaag 564721 ccgcgttccc tttcaagttg agcattggcg gcattatcaa tatccattat ggtttctgac 564781 tgttactggc attcttgaaa tagccggggc acttgctatg acagcgggaa tttggaatcg 564841 gtatgcagca attggagcag gtgttctgtt tgtcgttctc atggcgggag caattcatgc 564901 gcatatgttt cgagcaagac aatctgtcat catggcgata caagcgatga tttgtttgat 564961 tgtttcaatc atgatcatca tggggagtta cacgtaagct tttcactaat gtttaagaac 565021 aagcccattt gcaggaaatc tccttttctt atcgaataat agaaagtcca ggaattaact 565081 gaatcagtaa aatagagctc catttctgtg ttattcgtcc ggcatcagct gggctttttt 565141 tataaaggag gaatacagga tggcattcac tttggaagac atgactgagg aagagttcga 565201 agcctttcgc gggatgtccg tgcaaaattt tgcgaaacaa aacataacgt caggaacttg 565261 gacggaaaaa gaggcatttg agaaatcgga gcaggcatat gagaacatga ttccgaatgg 565321 gcgagacagc agcaatcatt atttttggaa catcacaaat gaccaaggag aaagaatggg 565381 ctggctctgg ctgtatgctg atccattaca tccgcaaaag gaagcgttta tctattcctt 565441 tggattgtat gaagcctttc gcggaaaagg acttgctcaa ttggcgcttc aaacgcttga 565501 tgaaagagca agagagcttg gtgcggaaag gctggctcta catgtatttg cacacaacga 565561 gacagccgtc tatctttatc agaagatggg ctatgccatg accaatatac gtatgcggaa 565621 acagctatgc tgaaaagccg cttacgttac ccaaatacaa catgcctatc tggaagcggt 565681 ggcagggtac tataagtcat cattagaaag attaaggtca tgggaggctt gaacatataa 565741 agaaaaagga caacagctgt tgtccttttc aatgccgctt gaactttctc cctcagtctt 565801 ttttgtcttg atgatccagc tcttttattc gtttcgtaag ctcattgaaa gcctgatcaa 565861 gctccttata ccctttatca tttggcgtca taaaactgag ctttcccagc acttcttgtc 565921 tttctgtctc aagctttaac cgaagctcct cccgctcatt tctttctgaa ggaacgtcgt 565981 ttaactgctt ttcgatgccg ttgtttgaga tgacgagttt actgtttgtt gttttttcga 566041 gaaagtatcg gtcatgtgaa accgccagca atgtgccgct gtattgtgac agtgtttctt 566101 ccagctgttc gcgtgacggc aggtcgagat ggtttgtcgg ctcatctaaa atcagcacgt 566161 ctttttcctc cagaatatat gccatcagct tgatctttac acgctcaccc atactcatat 566221 gcttgatcgg ttcagtccat tgggcggctg taaaacctaa gtgcctcatc agattttgaa 566281 cgtgccccct tgctttgaat gtttcattct caaataactc ttccggtgtt tgttctaaag 566341 gcaaatcaaa cacctcctgc gttaaatagc cgatgtttgc ggacggcgac acccatacac 566401 ttccttctgc tgtttcctgt cccagaatga tgttcagtaa tgtcgttttt ccgctgccat 566461 tggggcctat gatcgcaacc ttttcgccgt gctgaattgt aaagtttgcg tttttaaaga 566521 gagtcctttc tccaaacgct tttgttacat tctgaacttc taaaaaacgt tttcctgttt 566581 tgtgggttgt atcgattgaa aagcggactg tatattctgg ggtaacgggt tccgcctttg 566641 ctttttcaag ctctttttca agccgcttct gcttggattt tatctgggca tccgtacgct 566701 tcgcttttac ccggtgatat tctttaaacc cttccttttt cgtcgattga gcatgggctt 566761 tttccgacca agaagcgagc ccattcattt gtgcttcaat ccgttcaacc attttttgct 566821 gcttttcata ttcacgctgc tgggtgagtc ttttcttctc ccggaacttc atatacccgg 566881 agtaattccc tttgaattca atcagcgtct gatcctcaag cgaccatatt tttgttgcgg 566941 cttcgtctaa aaaatatcga tcgtgagaaa cgagaatcac agtgccgtta taatgtttca 567001 gctgttggat gagaaattgc aagctttttt catcaaggtg gtttgtcggt tcatctaaca 567061 gcagcagatc tgcatcctct gatagtcctt tcgccagccg cgctttcagt ttttcaccgc 567121 cgcttaactg atgaaaatca cgaagaggca catgccattt ctccagtaac ttcttttcgg 567181 caggtgtctg atccgcaaag gaatacgccg cggtttcctg ttcaaccaaa gccagtttta 567241 tatccttccg aaggatttga ccctgtgcag gggctaagtc attgtgaatg aggtgcagca 567301 acgtagattt cccagcgccg tttttgccga taatcccaat gatatctcct tgctgaacac 567361 tggcgtttac atgtttaaaa acagtttgat cctttacttc atagctaacg tttgttaatg 567421 ttacgatctc tttcatccat atccctcgct ttaaagggag aataaaaaaa tcctcccaaa 567481 tgtgttggaa ggattagccg tgcctgtgca tgatcaaata agctattttt tataaatagc 567541 agtgtcgtat atatagaaaa tgggcagact aatcctattt tttgatttga aatattgatt 567601 tcaaacggta aaaataagat tagttaatca ttgtccaccc atcatccctt cttgttttga 567661 ttacaaacac tatagcatac ctttaaattc aaaagcaaag gtcattttca tcaaaaaaac 567721 tcctgctctc atttttgagg caggagtttt gagtcttatt gatgcttcgc ttttctcact 567781 ttataaatca caatcagcaa aataaaccaa accggtgtga caaataagga aacacgagta 567841 tcctgtgcca gtgccagcac aaccagaaca aacgccagga acgcaagaat caggtaattt 567901 gtaaacggat aaagcggaag cttaaacttg tttgttttcg ctaattcagg tcttgttttg 567961 cggtatttca tatggcagat gaccgtaatc ccccaaatgt agataaagca tacggttgaa 568021 atacttgtga tcagggtgaa tacgccttct ggcatgatgt agtttaacgt aacaccgatt 568081 aaaatcacga tagctgaaaa gaataaagca tttctaggca ctttacgctg agtcagtttc 568141 gccattgact caggcgcatt gtgatctttc gccagggaat agaccatacg gcttgtactg 568201 aatacagcgc tgttgcatgc tgaagcagcg gatgtcaaca caacaaagtt gataatactt 568261 gcagccccga cgatgccaac agcgacaaat acttgtacga atgggctttc gctgggattg 568321 atgatatccc aaggatagat gctcataatc acgagaagag ccccgatata aaaaagcagc 568381 acacggacag gaatattgtt gatcgcctta gggattactt tttcagggtt ttctgtttca 568441 ccggccgtaa gcccgacaag ctcaatgccg acaaaagcaa acacaaccat ctggaacgag 568501 aggataaacc cgtgcatgcc attcgggaac aggcctccgt ggctccagag gtttgtgaag 568561 ctggacactc ctgagcttgt ggaaaagcct ttgaaaatca tcacaaggcc aatgacgatt 568621 aacgccaaaa tggcaatgac tttaatcaaa gcgaaccaaa attctaattc tccaaaaagc 568681 ttgactgtcg ccagattcat aatcagtaaa ataataagag cgattaagcc aggcacccat 568741 tgcggcacac ccgggagcca atattgagtg tagagcccga ctgctgtcag atcagccatc 568801 gcaatggaaa tccagcagaa ccaatatgtc cagccggtga taaaagctgc catatcgcct 568861 aggtagtctt gtacaaaatc cacaaaagag tgatagttca agtttgataa cagcagttca 568921 cccagcgatc tcataattaa aaagcaaatg atccctgtga tcatataagc aaataaaatc 568981 gaaggtccgg caaaatgaat cgatttgccc gagccgagaa ataagcctgt cccaatggct 569041 ccgccgatgg cgatgagctg gatatgcctg tttttcaagc ctctctgcaa cgtttgctga 569101 tttatattgt ctttcgtcat gtcgtctgtc actttatgtg ttcctccatt gaaaattgtt 569161 tattgagtca gcaatctatt tttaatgatt attataacac taaaatttct atctttttta 569221 ctaaaaaagg attgatgaaa agaattttaa tgtgatttgg actatttccc gaaaaaagcg 569281 gctccattta gggagccgct tttttatgct ttttcagttt ttgtcataaa caggtagagc 569341 ccgtaatctg tcggtgcgga tgcgtagcct gcctgccgca gcattgctgt gatattgccg 569401 cggtggtatg tcccgtgatt gacaacgtgg ggaagcagtt cggaaacagt tgttttcatg 569461 attccgcttg agggattttg aatctggagt ggcttattga gctgttcttt ttgctgtaaa 569521 aatagtatat agcgctcgga taacctcaga aaaaggtctt ccatttcctc tatttcttta 569581 gcctctgtct gttctttaag ctgttcagct aaagccaacg catcgctcaa ggttttgccg 569641 gaaaacactt caatccagcc gagatcagaa agataaacat gagacaatac atgggatatt 569701 gacggaaaca cgctttgaat ttcttgatgg tatatctctt ttggaagctc ttttaatcgg 569761 ttgaatattt gttgattggc ccagacgtta tattcataca atttgaatgc aaaatctgac 569821 atgttaaaat tccccctttc gtgtgtatag ctttcattat acacgaacat gagttcttat 569881 gtagagtgct cgaaaataaa atttgttgac atatatagtt tagaggaata aactaattga 569941 cattgaacat aaagtttagc ggggtaaact ataatgagga ggggaagata ttgaatgaac 570001 aaaagctatg tcaggcgata aacctgtttg tggaagtcct gcttgaaggg acagaatttg 570061 tgcatcgtga aatcaatcag gatgtcttca agcatatctc aagggaacag gcagacctgt 570121 tgaaaatttt aaaagtcaag ggcccaacct ctcccggcag cctggccatg taccaaaatg 570181 tacataagag cgcgatctct aacagactga aaaagctgct cgaaaaggga ttggttcaat 570241 gggacgactg tccggaaaaa agtgataggc gctctaagct tattaacatt acacccagtg 570301 gtgaacacat actagaagaa ttagattctg ccatctttaa cgcgctcaaa ccgttgattg 570361 atgatataga tgaggaacac ttacattcta tcatcgagat attcaccatt ttaaaaagca 570421 aatttaaagg aggagattct gccgaatgag agcaatcatc aaattcaagt gggcaattgc 570481 agccatagta ttagcactta ccgtcgtttt gagtttgttt tctccgaact taacggagct 570541 ggccaatcaa aaggggcagg cccagcttcc cgctgatgct gtttcagaaa gggcaaacgc 570601 cattttaaaa caagcgggag aagacaataa ttcgatcagt gtagtcttta cattagacaa 570661 cgctataaag aaagaaacag agaatcagct ccggataata attgataaaa tcaaaaagat 570721 cgacggtgta gaagaggtaa catctcctct gtcagcggaa aaagaagtca aagaccagtt 570781 gatgtcgaaa gacaagaaaa ccgttctcat gcctgtcacg attacaggtt ctgataaaaa 570841 ggcggaaaaa attgcggacg agatttatca aatcgttcct gatgacttga cggcatatat 570901 tacgggagct tcccttatca accaggattt cgctcacagc tcagaggaag ggcttaagaa 570961 aacggaagtg ataacagtct gcctgatcat cggtttactg ttgatcgtgt tccgatctgt 571021 tgtgacgcct tttatcccga ttgtggttgt cggtttttct tatctgatca gtcaatctat 571081 actgggcatc cttgtataca atgttgattt tcctatctcg acgtttacgc aaaccttctt 571141 agttgcgatc ctgttcggca ttggaacaga ttactgcata ctgcttctta cacggttccg 571201 tgaagaattg gcaaacgggc atgataaaaa agaagcggcg cttatcgctt accgcacagg 571261 gggaaaaacc ttatttatca gcggatttgc ggtattgatc ggattttccg ccttaggatt 571321 tgcgaagttt gcgattttcc aatccgcagt aggggtagca gtcggtgtgg gaattttaat 571381 gatcatcctc tacacactgc tgccattatt tatggtgacg ctgggtgaaa aattattctg 571441 gccttctaag aaagtgctgt cacacagtga taacaaacta tgggcgtttc tcggcagaca 571501 ctccgttgcg cgtccgtttc tgttcattgt catcacggtg gtgattacgc ttccgttcat 571561 cttgacctat gatgaccaga tttcattcga ctcaactgcg gaaatcagca gcgattataa 571621 atctataaaa gctctcgagg ccattaagga tggattcggg gaaggaaaag cgttcccgat 571681 caatgttgtc gtaaaaggag acaaagatct tacaacagct gatacaatcc cctatctagg 571741 aaatatcagc aaagcgatcg agaaagttga tcatgttgac tctgttatga ccattacgca 571801 gccgactggt aaaaaaatca aagatttata tattgataac cagctaggat cggtttcaga 571861 cgggctggat aagacggtga aagggattgc cgatgtccaa agcggattaa cggatataga 571921 aaacggactg aatcaaatgg cagggcaaac cggctcggcc tcaaatggag ggtctggcgg 571981 ttcactgggc gatgcggcag atggcttggg caaaatcaat cagcagctgc agctcgtgag 572041 caaacagatt tcccaaaccg gcaataccgc acagaccgtg cagcagctta cggcaataag 572101 cggacagctt ggccagattc aaaccggcct tgaacaagcg aaccaacagc tctcaggcca 572161 gcaggcacaa gccggaacgc tgacagaaag cctgaaaaag ctgtccgaag gcgtgaaaag 572221 cgcaaatgag ggcctgacga aagtctctga cggtattaca gcttccagtg atatattaga 572281 ggacatgagc aaaagtccaa ctgtaagaga tactggcata ttcattcctg atcaagtaat 572341 gaaggacaaa gactttaaga agtcaattga ccagtattcc tttgcagacg gcaaaggtgt 572401 tcaattaagt gtcgttctgg attcaaatcc gtactcagaa caagctatta cgacaataaa 572461 ccaaatcaaa aaagctgtcg caaacgaagt tgacggcact cctttggaga atgcacagat 572521 cgtgtacggc ggggtcacga gtatgaatgc ggacttaaag gagctatcca caacggactt 572581 ctccagaaca atggtgatta tgattatagg cctgtttatc gtgttaacca ttttgttccg 572641 ctcaatgatc atgccgattt atatgatcgc gtcattgctg ctgacgtact atacgtcgat 572701 atccataaca gaattaattt ttgtaaacgg cttaggaaac gcgggtgtca gctgggcagt 572761 gccattcttc agctttgtca tcttgatcgc gttaggggta gattattcga tcttcttgct 572821 ggatcgattt aaggaagagg tgcaccttgg cattgagcaa ggtgtcgtca ggtcaatgag 572881 caaaatggga tctgtcatta ttacagctgc cattatattg gccggtacgt tcgcggcgat 572941 gatgccttca ggtgtcaata cactgatgca ggtggcaagt gttatcatca tcgggctctt 573001 gctttacggc cttgtcatac ttccgctctt catcccggca atcattgcga cctttggaga 573061 aggaaactgg tggccgttcg gcaggaagaa aggaaaagag taatcgagag aagagtgatg 573121 aatggtcatc actctttttt catgactaaa cgactaactt cagacgtgtt acccaaaaag 573181 atcagacgat caaacggcgg ctgtacttaa aaacaaagag cccggaaaac attcccgggc 573241 tctttgtttt atttccattc tgcaattgta tcaatcggca gacggtagga agcatagcct 573301 tcgtctgctg cttttccgat agaaagtagc ataaccggta cataacgttc tttatctaat 573361 ccgaaggttt ccgcgatgtt ttctttatcg tatccgccga tcgggtttgt atcgtagcca 573421 tgcgcgcgtg cagtcagcat cagctgcatg gaaacaagac ctccgtcaat caggatcgtt 573481 tcacggttga cctgtgccgg aagcttttca aaatgtgcgg tcagcgcggc gatttgtctg 573541 tctttgacct cctgcggcat gtaaccaagt tccacggctt ttgaatagat ttcttctaga 573601 tagtctgcgt tgttcatgtc tgcaaataca gcgatgacag cagatgatgt tgtgacttgt 573661 gtttggttaa agcttgcaag cggtgcgagc ttttcttttc cttccgggct gtcaatgaca 573721 agaaaacgcc atggctgcgc gttaacagaa gatggggcag ttgttgcttc ctctaagatc 573781 tctgtcattt cttctttgct gatttttact gccggatcat agttgcggat agaacggcgg 573841 cctttcataa tttccataaa atcgtttgtt ttgatcatgt tgatacactc ctcttaagct 573901 tcgatattat ttatattgtt tcgcatgcgc gccagcacat caatgagcag gcggcgttct 573961 tctgcgctta catttgcgag catttccttc atgaaacgct ccttttcctt cttagaagac 574021 tcaattcgct ctcttccttg gtctgttaac cgaacaaggg tgatgcggtt gtcctcaggc 574081 ttgcgccgcc ttgataccat gcctttggat tccagctgtt tcaggtgtct ggtaacggct 574141 gcgctatcga tatttacttt cttttgaagg tcgctttgac tgatctcatc tgcatgataa 574201 agcaatgtca gcaattccaa acgagattgg ctgatgcccg tgcatgcctc gaacttcacg 574261 ccaatcacct tgttcacgcc ttgcagctga tataaaatct cggcttcctc tgaacaaaat 574321 gacgccaaaa cccatccctt ctttcctgtc aaaactatta attgatatat caatgattga 574381 cacgtcaatt aatatacaac gattgatttc atcttgcaag ccatttgcac ttttgaacaa 574441 cctcccagcg cataaaattc gctaggctag aacttagcaa aaaaagctgg ccgcttcttc 574501 agatgatgct ggtcacgatg attccctgca tcattcccat ttataggtgt tcggaatatc 574561 actttgccgg cccgtgctca agcggctttc acaggctgaa agttatgata caatatacaa 574621 atgtttcaca gcttcaatcc atagttggag ctgacatcca ttatataagg gactaggttg 574681 aagggaaggt ttgataacat gctgcacaat ccaactggaa aagaacgctt ggcactagcg 574741 tttctgctcg gcatgcttgc tatattgggc ccgcttaata tagatatgta tttgccaagt 574801 tttcctgaaa tcgcgaaaga tttatcagca agtgcttcac ttgttcagtt aagtttaaca 574861 gcctgtctgg tcgggcttac gatcggccag ctgattgtcg ggccggtcag cgatgcgcag 574921 ggaagacgaa aaccgctatt aatctgtatt tttttatttg cgttatcttc tctgttttgt 574981 gcactgtcgc ccaatataac aactttagtg gctgcgcgtt ttttacaagg cttcactgct 575041 tctgcagggc ttgtgctgtc tcgcgcaatc gtccgcgatg tgtttaccgg aagagagctt 575101 tctaaatttt tctcgctgtt aatggtcatt accgcggtgg cgccaatggt tgcgcctatg 575161 acaggcggtg ccattttgct tttgccgttc gcaacgtggc atacaatttt tcacgtctta 575221 atgatcatcg gatttttact agttcttctg attgcattga ggttaaaaga aacgcttccg 575281 ctggaaaaac ggattccaag ctcaatcgga acatccgtca aaacgatggg cagcctgctg 575341 aaggatcgat cctttatggg gtacgcgtta actgtcggat ttattcacgg gggaagcttt 575401 gcatatgtgt ctggtacgcc ttttgtatac caggatatct acggggtgtc tccgcaggta 575461 tttagtattc tttttggcat taacgggctg gcgattatat cgggcagctt tatcatcgga 575521 cgctttggcg gaatcattca tgaaaaaagc ctgcttcgta tagcggtcat tacggctatg 575581 attgcgacgg ctgtgctatt aaccatgacc atgattcacg gtcctcttgc tacattagtc 575641 atatccattt tcatttacat gattacgatc ggcatggttc tgaccagcac gtttacccta 575701 gccatggaaa agcaggggca ccgcgccgga agtgcaagtg cgctgcttgg aatgcttccg 575761 ctgctcctcg gttcaatcgt gtcaccgctt gtaggcatta atgagacaac agccgttccg 575821 atgggagcca tcatgtttgt gacagctgtc atcggctcac tggcgttttt tggattaacg 575881 aaagaacgag tagggcagaa ttcataaaaa aacctgacat gacgtcaggt tttttgtttt 575941 atttagaata acaacagcag gcctgcaatc gccggagtca aaaagatggc tgatttcaaa 576001 accacctttg gcatgaggtt ggtgaatttc gcgcctacat aggccccgca cattgtcccg 576061 accagaactt tgacaagtaa aacgtaatca acaaaacctt ctgtaatata tccgatgcct 576121 ccacctacag ccagagggat gatcacaagc atcgtcgttc cgacagaatg gcgaatggac 576181 agattcagca taatcattaa accgatttga ataaaaggtg ccgacccgat gccgaatgtg 576241 ccggaaagaa cgccggctgc aattcctaag atgaccgctc tcgtatacgt tgaaagagtg 576301 ctttgattca cttgagcctt ctcttttaaa ataaataatc tgattaaaat gagaattgct 576361 gataaaaata acattccagc cgtcaaataa tgaagcaaat cagccggaat aaaagaagtc 576421 agcttggcgc cgaaaaatga gccaaccgca gcaaagcctc cgactattaa gccgattttc 576481 atttgaatgt taccctcgcg atagtggctg tatgcccctg ataagcttgt aaaagccatg 576541 ccggcaagcg aagtgcctaa agccgtatga atcgggatat ggaaaagaag cgttaaaagg 576601 gcaatgacaa agccggctcc accggcgcca ataaagccta aaataattcc tagaagaaac 576661 ataacaagaa taatgagcat attttttcct ccattgaaaa gatgtaaaaa tgtaatcgtg 576721 cgctattctg gcggaggtat ggtgtcctat tgacgaagaa aaacacgccg ttttttcagt 576781 tgccagtagt ccgtcgaccg tcgttcagca aacatatcgt acctcaaatt cagggatctg 576841 acaaggcagt ttgttgcttc ccattaccat ctgttatatg attttgatga agaaaagccc 576901 ttgaatatat tcaaaagagg tattatatat ggacgatttt aaattagata agccgactcc 576961 ctactacctg caattttata accagctaaa aaaaatgatc ttcaacggga cttttaagcc 577021 tggggaacgg ataaacgaaa cacagctggc gaaaagcttt ggcgtcagcc gctctccgat 577081 aagggaagcc atgcgattgc ttgagaaaga tggtttgtta aaagcggatg accgaaatgg 577141 gttttcgatc acgtcgttaa cggcaaaaga tgtagatgag atttataaaa tcagaattcc 577201 gctggagcag ctggcagtcg aattagtcat agacgaagcg gacgaagaag agctgaccat 577261 actcgaaaaa cagcttgaag aaacagagaa agcgattcac aacggcacgg aagatacaga 577321 aatcattcgt ttaaaccaaa aatttcatga gctgctggtt gatttcagcc ataacagaca 577381 tttgaaaaat ttgcttgagc atgtaaatga cctgattcat ttttgcagaa tccttaatta 577441 taccggcgac caccgcgcag aaacgatact gcgtgagcac cgcaggatat ttgaagaagt 577501 gaaaaagaaa aacaaagaag cagccaaaca acatgtgctg gctcatttca atcatgactg 577561 tgagcatttg aagcatgtgc ttgaagaagg taaagagaat tgatttgtat gatccggtac 577621 caagggagag cagaaccctt ggtatttttt tatgtattca ccacatatct aagaggcccc 577681 gttaataaga ttttatgatg gtttgactaa cgaataatgg gggttaaata tgtttatcca 577741 tatcgtcggg cctggtgatt ctttgttttc gataggcaga agatacggtg cttctgttga 577801 tcaaatacgg ggtgtgaatg gtttagatga aacgaatatc gtgccggggc aggctctgct 577861 tatccctctt tatgtatata cagtccagcc gagagatacg cttaccgcca ttgcagctaa 577921 agcgtttgtg ccattagagc gactgcgagc ggccaatccg ggcatcagcc caaatgcttt 577981 acaagcggga gcaaaaataa cgattccttc gatctcaaat tacattgcgg gaacgttaag 578041 tttttatgtg ctccgaaacc cagacctcga tcgggaatta atcaatgatt atgcgccata 578101 ctcgtcttcg atttcaattt tcgaatacca tattgcaccg aacggcgaca ttgcaaacca 578161 attgaatgat gcggccgcta ttgagacaac ttggcaaaga cgagtcacgc cgctggcaac 578221 aataacgaac cttacatcag gaggcttcag tacggagatt gttcaccaag tgctaaacaa 578281 tccgacagcg agaaccaatc tggtcaacaa catttatgac ttagtttcca caaggggata 578341 tggcggtgtc acaatcgatt ttgagcaggt gagcgccgcg gatcgcgatc ttttcactgg 578401 atttttacgc cagctgagag atcgacttca ggcgggaggg tatgtgctga cgatagctgt 578461 tcctgcaaaa acaagtgata atatcccatg gctgaggggc tacgattacg gggggatagg 578521 agcggttgtc aattatatgt ttatcatggc ttatgattgg catcatgcgg gaagtgagcc 578581 gggtcctgta gcgccgatta ctgaaataag gagaaccatt gagtttacga ttgcgcaggt 578641 gccgagcaga aaaatcatta tcggagtccc gctctacggg tacgactgga tcatcccgta 578701 ccagccgggc acagttgctt cagcgatttc aaatcaaaac gcaatcgaaa gagcgatgag 578761 gtaccaagcc ccgatacaat attcagccga atatcaatca ccgtttttcc ggtacagtga 578821 tcagcagggg cggacgcatg aggtatggtt tgaggatgtc agaagcatga gccggaagat 578881 gcagatcgtc cgtgaataca gattgcaggc tattggcgct tggcagttaa cgctgggctt 578941 tacgccgggc ccatggcttc tgcggaaatt ttttacgatc agaaaagtgt aaaaaaagac 579001 accagagctt gggtgtcttt tttttgatta agtccagagc agcagaatag ttcattcatt 579061 tgtaccttgc atgggttgtg ttcccatttt acgattagta gtagtctgat caaacaaaga 579121 gtcagaatac gatttgagag ggagttgtct acatgaagac agtattgatt ttgaattttc 579181 ctgcggaagg ccatgtgaat cctactttag gcattacgaa agcgttttcc gataagggat 579241 atgatgtcca ttatatatcc actgaaaaat ataaaaaacg attagaagca gcgggagcaa 579301 cggtccatct tcaccgggat ctgctgcgaa cgacacctat tcatgtcggt tcgcccaatg 579361 gcattcttga tttcgtgaaa atccatatca aaacgtcatt ggacatttta cagattgtca 579421 aagacttatc taagagcatt caatttgatt ttgtttatta tgataaattc ggcgcggggg 579481 aattggtgag ggattactta gatattccag gggtctcttc atcggcgtct ttcctgtttg 579541 gcgaggagca tctgaaaatc ctgccgctgc atccggagtc tggagcgccg cttgaattgg 579601 atcaagagtg cgaagacctt ttggcaaaaa tgaaagaaac gtacggtgtt gccccgaaaa 579661 acctggttca attcatgaac aataaagggg aattgaacgt agtgtataca agccgttatt 579721 ttcagccaga aagtgatcgt ttcggggatg aatgtctatt tatcgggccg agctttccaa 579781 agagagcgga aaaaacagat ttcccgattg aacagctaaa agatgagaag gtcatttata 579841 tttcaatggg gactgtactg gatcatacag aggatttctt caacctttgt attgatgcat 579901 tttcaggctt taacggaaaa gtcgtcatcg ctgccggaga aaaagcggac ctgaccaaat 579961 taaagcaggc gccggaaaac tttatcattg ctccgtatgt ccctcagctg gaagtgctgg 580021 agcaatcgga tgttttcatt acacacggcg gaatgaacag cgtaaacgaa ggcattcatt 580081 tcagcgtgcc actggttgtc atgcctcatg acaaggatca gccgatggtg gcgcagcgtc 580141 tctctgaact ccatgcaggc tatgtcatct ctaaagatga agtcaatgcc caaatattaa 580201 aacaggccgt agatgaggtt ttgcgcaacg atcagtatac ggcaggcatt aaaaaaatca 580261 atcaaagctt caaagaatgt atggacatgg aagaagtgat ggagcggatt gatgagttga 580321 ttcgccaaaa aaacaaataa gaaaaagaac tcccgtacct tgtacgggag ttcttgattt 580381 aaaacttgat tttgattttt tgagcatcac tgattttctt atggttatgg tcaaagacgt 580441 cacttgtcgt gatttcgatc cacttgatct cttttgtttt cttctcagca tccgcggcct 580501 tatcatgagc atggccgctt gatgcgttca caataaagcc gagatttccg gacttttcgg 580561 cgccgccttc caattcgccg tttaactctt caagataaat atctttgttc caatcaaagg 580621 tttcacccgt atttgttttc atcaatgcaa tcggcgcaac atttactttt tttgtagagg 580681 tgttcttgat atcaacgaaa accttaacga aatcaaactc ttcatcgtgt gttaactcat 580741 gaaagtaatc aatcatgctg tagtccgggc gcaagtggat cagcttcatt tcttttactg 580801 ttaactccac gtcgccaatt ttataggttt tgttcacttg tttgatatct tttaagacag 580861 cttttccttt atcatctgaa aacgtttggc cgaccttatg caatgtccgg tcatcagtta 580921 cctgggaatt aggctgataa tcatctgtgc tgtccttctg ggatgaagtg ctttgcggct 580981 cagcttttac tgttttctcc ccgcctgcat gctgtttttc agtactggcg tttgatgagc 581041 agcccgcaag catgatagca aaaacgagaa ttgaaagaat tcttctcatg atgattcctc 581101 cattaaaaag agatcccgtt acttcataca agcaacggga caccttgtat tcttttactt 581161 atcgttaatc ttaatgttgt attgtaaagc cttgaaaaca tttttggcga tttctgtatt 581221 gtcgatttgg ccggcaaatg tctcactaga cggaccgtat gcatagacgg gaacatcttc 581281 accggtatgt ccgcctgttg tccatccagt gtgagagcgt ttattaaaga tgttctcgat 581341 tgcgttatcg atatccagta cttccttcga ttttgccgct tcttcaacag attgaatttc 581401 ggcttttgtt aaagccaatt tcttttgatc gatatatgtt ttcaacgttt tttcaacatc 581461 cgcgccgtca gcgatctttt ctgccataaa gtctggtgtg cgctttgcgg ctttaatggg 581521 ttcactgaac cagttgtaga tgccgtccgc accgatggaa tatccgccgg ttgagtggtc 581581 agccgttgcg acaaccaatg tgtgcttgtc ttttttagcg aaatcaatag ccgccttata 581641 agcttgttcg aagtcttcca tctcgctcat ggcgccaacg atatcattgt catggcccgc 581701 ccagtcaatc tggctgcctt ccaccatgag gaagaatccg tctttatcct tgtttaattt 581761 tttaatggct gtgtttgtca tatctttaag tgatggaata tccttcgtac ggtcaatctt 581821 tttaggcagg ccgccgtcag cgaataggcc gagaacttgg ctgtctttgt ttttcagcat 581881 gtccttgcga tcatccacgt agctgtaccc cgcctttttg aattccttaa tcaaattacg 581941 gtccttacgg tcaaaattgc tctttcctcc gcctagaagg acatcaattt tgtgcttgcc 582001 gttgaccatc tcatcaaaat aatcatccgc aattgagttc atattttttc ggctgtggtc 582061 gtgtgaacca aaagaggccg gagtggcgtg tgtaatttct gaagtggcca caagtcctgt 582121 tgcttttcct ttttctttcg cagcttcaag caccgttttg gcttctgacc cgtcgttatc 582181 aacggctatg gcattattgt atgttttaat tcccgcagac atagccgttg ccgccgctgc 582241 agaatccgtt acattttgtt caggatcatc ggggtaagtt gtttgctggc cgacaagata 582301 ctgatcaaaa gccgtaggct ccacaacttt tgtcttttta ttatccttta agtatcgata 582361 agcagacgta taagacacac ccataccatc accaatcaga acaataacat ttttaatttc 582421 gtcttggttc ccctttttct tttcctgggc gctggcttca ggcacactgc cgctggctaa 582481 gctgctgaac gcaattgatg ataaaaccgc gataggcagt aatttcttcg ggaatttttt 582541 caactggata acctcctaaa tatagatgaa tctcaatgac aacccaatta tatttttaaa 582601 ctgttaagct agtattaatc gattttaaag attggattta caagaataat gaactggcac 582661 ccttaaataa tggttattct tttatgagaa gttttagaag gaaagagcga tagtactaaa 582721 gaaataaatt ggaggaatag atactggccg tggataggcg gactgaaatc tgctatagtc 582781 gcatagaagc aacccgctta catcttgaac aatttaaagt attacgttgg aaagaggtat 582841 tgtgtaagca catgtctgag cagttcatat ggagtggcat cattttattt taggagggaa 582901 caacatggac gttttttctg agtacttagc ggggattgct gacccgttcc accgagaaag 582961 aacggaagag gtgttaactt ggataaaaaa taaatatcca aatttacata cagaaataaa 583021 atggaatcag ccgatgttta cggatcacgg tacatttatt attggcttta gtgtttctaa 583081 aaagcattta gctgtcgctc ctgaaaaagt aacgatagcg cacgtagagg atgatattgt 583141 gaaggccgga tatgattaca ccgagcagct gatacgtatc ccttggaacg gtccagttga 583201 ttatacgcta cttgagaaaa tgattgagtt taatattctg gacaaggcgg actgctccac 583261 tttttggcgg aaatgaagaa aaaggcataa catatgagct gtataaaata tgttacgcct 583321 tttcatttgt ctatttttcg ttttgatcat ctattgctgc ttttcatcaa acaaggtctt 583381 ttcattgagc gtaagctgac tcgcagaata atgattacct tgtttccatt tcacttcaat 583441 cgtaatatca tggccttcaa gctcatgttc atctaaccgc tctaaaaaag aaacggactt 583501 ttcttttgcg cttccatcag aaaaagtgcc tccagcataa tcatgcatcg ggatttccgt 583561 gtcagaactc agcagaactt catcatcctt ttttacaatc agtgattcca gataagtgtt 583621 gtctatttca attgtatcac cgatccaata aagtttgccg ctgtattcat tcggtgcatc 583681 ttcatttttt gtgaaaacag cttcccaatt ctgatctttg ctttctccct gccaatttgg 583741 atactccaaa cgaacatgat gaatcaggtg ataggaaaaa aagatcaagc agaaagcgat 583801 taataggaat gccgtgaaaa tgagagggta tttataatga ctggacataa aagactccta 583861 ttcgtttaat caattacctt cgaaaataga atttcatccc gaatcaaaat gccgttttca 583921 gccacctcgg gaatctccgg cttgagtcgg cgcgcttttt caactgcgtt cggaaacact 583981 gcggcgaatt gatagcctct cttttgataa aacgctatcg catttacatt atcattcgtt 584041 gtgataagct ttattcgttg acaatgtgca tgtttagcct tctcttcaac ctgctgaagt 584101 aaagctgtgc cgattccttt attttcaatc atactatcta atgaaataat ttcacaatct 584161 ttcccatcta ttgtgtatgt aatacagcca atgatttcgc cgctttcatt tactgcggca 584221 aatccatcta attcatcaca ccgaaaaatg ccgctggaaa tcgccatctc gggtgtaccc 584281 caatgcttgg caaaaaaatc ggtcaacata tgtttcgcta tctcattgtt tgggatgatg 584341 atcatcataa cactcctcta ttgaaagatt gcatatgtac tatcaatata aacaatatat 584401 aacaaaaaaa atagatgttg aggtgacggc atggaaatca gcgatatcat ttacgggcag 584461 caccatatag acggagtgct ggaagagctt atcaaaagcg ctcctgtgca aagattaaaa 584521 ggaatctatc aaggcggagc aagcttttta gtcaatcgaa agtggaatgt gaccaggtat 584581 gagcactcca tcggcgtgat gctcctcatc aaaaagctcg gaggaacgat agaagaacag 584641 attgcgggtc tgctccacga cgtatcacac acagcttttt ctcatgtggt cgacgttgtc 584701 tttgaaaatc aagcagaaga ctatcatgaa aacatctttc aacaagtcat tgttcactct 584761 gaaatcccgg acattttaca aaaacacggc tatcatactg aagaactttt atctgacgat 584821 tcaaggtgga cattgctcga acagcccgca ccggagctgt gtgctgatcg gacagactat 584881 acgctgcgtg atatgtaccg atatggacac attaacctgc acgaagcgca aacctttttg 584941 gatcatctta ttgtgagaaa cggaaggatg tttcctgata gtattgaagc cgccgaatgg 585001 tttgtcagtg tgtactacaa ggaagtaatt gatttctttt tgaatcctgt gaatgtatat 585061 ggatatgaat atttagcgcg agcattgaag gcagcgctgc ggcatgatgt catatctgca 585121 gaggatctgc tgaaaacgga ccaagaggta ctgaacatcc tgcgtgcatc aaaaaatgaa 585181 gaagtcctga gcttgcttac atccattcat cccggcatac aagtaataga ggatgacatc 585241 cagtacgatt tccatcaaaa gaagaaaatg cgcctaatcg atccatccat ttttcttgat 585301 gacaaatgga tcaaatcctc aggtgtttct gaaaaggtga ggaaaatggg tgaggccgct 585361 tatcaaaaag caaaaaaagg tgtgtatata aaaatcttaa agcagtaatt gccgcctgac 585421 agcggctttt tttatgtttg gctttgcaaa caaaggggaa taggacaaac tgcgggaacg 585481 ctttatgaga atatcagcgt atttacatac cgttcggggg tatagtatta tcgagagggc 585541 atgttttcat tgtctgcggg caaaagttac aggaaaaaaa tgaagcaaag gagaatgaac 585601 atgaaaatct ctaaatatgc actgggaatt ctgatgttat ctctagtttt tgttttatca 585661 gcatgcggca ataacaacag tacgaaagaa agcacacatg acaatcattc agactcctca 585721 acacatgaag agatggacca ttccggatca gctgacgttc cagagggatt acaggaatct 585781 aaaaatccga aatacaaagt aggcagccaa gtaatcatca atacttctca tatgaaaggc 585841 atgaaaggtg ctgaagctac ggtaacaggc gcctatgata caacggcgta tgttgtttct 585901 tatactccga ctaatggggg acagcgtgtg gatcatcaca aatgggtgat ccaagaagaa 585961 atcaaagatg ccggagataa aacgttacaa cccggagatc aggtgatttt agaggcttct 586021 catatgaaag gcatgaaagg agcaacagcc gagatcgatt ccgcggaaaa aacaactgta 586081 tacatggttg actacacatc gacaacgagc ggcgaaaaag tgaaaaacca caaatgggtc 586141 acagaagatg agctttcagc taaataataa aaaatcctcc ttttacaagg aggatttttt 586201 tgctgtttga acaggtcttg ttaaagaaat gaaagcaaac aggacagcga tgatcacaat 586261 cgatccgccg caccatgccg ttgacaccac agtacccgtc tgatccaaaa caacaccgcc 586321 aatggctgag ccaagggcaa ttccgacttg gagggccgat gtgttaaagc tttgctgaat 586381 gtcagacgaa tcaggtgcaa tttcaattaa atagctttgc tgagccgggg cgaggctcca 586441 gctcagaaga ccccaaatca ccatgacagg caaaaagaaa atcatagacg atgtagacag 586501 cggcagtaag aacataatga tggcaaagga accggtcacc agcaaaatgc tcttaaagga 586561 accaagccgg tcagatagcg ctcctccgaa agggcctccg catacagcag atatcccgaa 586621 aaggaaataa caaatgctga cccagaaaga gctcaggtga agagtctctt ctaaaaacgg 586681 cgcaaagtaa gcgtaaagcg tgtagtggcc agctaatgta aacatcgtga cgaggtgtga 586741 actcgcgatt ttcagattac cgatcgtctt gagttgttcc cggaaaggaa tcattttctc 586801 cgccggtatt ctttcaaaga agattgaaat aatcagcatg gagatcagtg ccaacaggcc 586861 gatgccaagg aacaaaatcc gccacccgaa ggaatcgctg attaagattc cgagcggcac 586921 gcctaatgcg atagcagagc tgaatcccat aaaaataatt ccgattgcgc gggctctgta 586981 ttcaggcgct acaattttcg gggcaattgt taaagaaagc acaacaatca gccctgtact 587041 cattgctgcc aataccctag ataccatcag tgttgcgaaa ttagggctga aataggcgac 587101 aagattgcta aggaagaaaa caaataaagc aattagatat aagcgcttcc gctcaatctt 587161 cgcagtcaat gccaaaagca gcggcccaga tactgcatat cccagcgcaa acacactgat 587221 cagctgtccg gctgaaacaa tggaaatgtc taaatcattt gcgatctgag gaagaattcc 587281 ccccacaatt aactcaacca atccgactgc aatcgtagaa gctgcaagca ggaaaacttt 587341 gaaattcata acaaactcct ttacttaaat gttttgataa ataaaaaaaa tcctgattac 587401 aaaaaatgtc ataaacaaat tttgtaatca ggattttacg gttcctggta gacaccctca 587461 aaccatatta ttgaggttat acaagtgata atagctattt aattgattcg tttccgttga 587521 tgagtgtacc acattatgaa tgaatcttcc atagaaaaat ttataaaacg gtgaaccgga 587581 aaaaaatatg attatattta ttttataaaa gtatagacat ttaaaattaa atgactataa 587641 taatcaatgt aagcgtttta ataacagggg ggatagcagt tgaaaaaaat attactcgcg 587701 tgcagttcag gaatgtctac cagtttattg gtgacaaaaa tgaaggaata cgcacagtct 587761 atcggtgagg aagcggagat ttgggctgtt ggccaggata aagcaaaaga agacatgaga 587821 aaagcggatg ccgttttgat cggtccgcaa atgagctttc tgaaaagcga gctccaaaaa 587881 gaagcagatc aatacaacat tcaagttgaa gtcattgaca tgatggccta cggaatggca 587941 gatgggaaaa aagcgtatga gcaggcattg tccttaatgg tgaatcaata atggaacaga 588001 tgaaaatcac gaatttaaca gacgagcaaa tcagttttca gctaatcctg cacagcggaa 588061 atgcccgcag ctgcatcata caatcactgc gcgcctataa agaagggaaa aaggacgagg 588121 ctgatgccct cattgccaag gcggagcagg atttatccgc ggcccatgac attcactttc 588181 aaatgataca gaaggaatcc ggcggagaag caacagcttt ttcattgctg cttatgcatg 588241 cagaggatca tctgatgtca acattatcca tgaaagaatt agtgaaagag atgcttgatc 588301 tctttaaaac caagaatata taaaaaatcg gggtggatag ggtgttcgag aaaatcagcc 588361 aattccttgt tccaattgca gggaggttaa acaataaccg ctatttgcaa gtgttgcgtg 588421 atgcatttat gctggctttc ccgctgacga tattcgggtc catttttgtc gtgttaacga 588481 atttgccgtt tctaaacaaa atcatgaacg cctcaatgct tacgtcgttt cagtctcatt 588541 tcggcattgc ctccacggcg acaatgggca ttatgtctgt ctttgttgtg ttcgggatag 588601 gctattacct gtcgaaaagc tatcaggtcg aagctgtatt tggcggagcg atcgctttgg 588661 tttccttttt gctcttaacg ccatttatca ttcagccgga aacaggtgat gccattacag 588721 gggttatccc ggtcgatcgt ctcggtgcaa aagggatgtt tcttgggatg attacggcat 588781 ttctttctgg cgaaatttac agaagaatcg ttcaaaaaaa cctgacaatc aaaatgccag 588841 ccggcgttcc gcctgctgta gcaaaatcat tcgccgcact tattccggct tttatcacat 588901 tgactgtatt tttgctgatt aacgtaatgg tgactctgtt ttttaaaaca aatatgcacg 588961 acgtcattta tcatgcgatt caggctccgc ttgtcggact tggaagcggt atcattccaa 589021 cactgattgc cgtgtttttc attcaaattc tttggttttt cggactgcat ggacagatca 589081 ttatcaactc cgtgatggac ccgatttgga atacactgca ggtagaaaac ctttctgctt 589141 acacggcggg aaaagaaatc cctcatatta tttcaaaacc gtttatggag atttatacag 589201 tagggatggg cggaacaggg atgacgcttg cgattgtgtt taccattctc atattcatga 589261 aaagcaggca gatgaagcaa gtatcaaaac ttggcctcgc tcccggtatt tttaacgtaa 589321 acgaaccgat tatctttggg cttccgattg tcatgaatcc gatcattatt gtgccttggg 589381 tgctggcacc gatggttgtt acgctcgtca cctatctggc tatgtcagcc gggctcgttc 589441 cgcctccaac tggtgtgaca gtgccgtgga cggttccatt attcattaat ggcatcatgg 589501 cgacgaactc aatcatgggg ggcgtgatgc agcttatcaa tctgctgatt gtcttcgtga 589561 tctggtttcc gttcctaaaa gcaatggata aattaaatct ggcaaaagaa aaagaacagg 589621 ctgtgcagga gacagctgct cagcaaaatg ataacagcat aaaaatgtga cataagggga 589681 gagagacttg gcacatacag aacaatatcg ttttccaaag gatttttggt ggggatcatc 589741 cgcttcagca acacaaatgg agggtgccgc cgacagagac ggaaaaggcc agaatatatg 589801 ggattattgg tttgaaaaag aaccgcatcg tttttttgat catgtcggac ccgcagacac 589861 atcccaattt tacgacaact ataaagaaga tatcaggctg atgaaggaac ttggccacaa 589921 ctcgttccgg atgtcgattt cctggtcacg tttaatacca aacggaacgg gcgagatcaa 589981 cgataaagcc gcagatttct ataacaatgt cattgatgag ctgatcgcta acggaattga 590041 accttttgtc aatttgtttc atttcgatat gccgatggcg cttcaaaaaa tcggcggctg 590101 ggtcaacaga gagacggttg acgcgtatga aaactatgca agaacttgct tccgtttgtt 590161 tggcggccgg gtgaaaaaat ggttcacgca taatgaacca atcgttcccg tagaaggcgg 590221 atacctatat gattttcatt atccaaacaa ggtcgatttt aaagaggccg tccaggttgg 590281 atttcatacg atgctatcaa gtgcccgcgc cattcaggct tacagggaga tgaagcagga 590341 cggaaaaatc ggcatcatct taaatttgac cccttcatac ccgagaagca gccatccggc 590401 ggatgtgaaa gccggggaaa tcgcagacgc gttttttaac agatcttttt tagacccatc 590461 tgtcaaaggc gaatttccca aagagctggt tgacattttg aagcatgaag gctttatgcc 590521 tgattacaac gctgaagatc tcgacatcat caaaaagaac acggttgacc tgttgggagt 590581 gaattattac cagccgagac gtgtgaaagc gaaagaacat cttccgaatc ccgacgctcc 590641 ttttttgccg gacaggtatt ttgatcccta cgtcatgccg ggccgcaaaa tgaatccgca 590701 tcgcggctgg gagatctatg aaaaaggcgt ttatgatatt ttgatcaatt taaaagaaaa 590761 ctacggcaac atcgagtgtt ttatctctga aaacggtatg ggggttgaag gtgaagagcg 590821 attcagggat gaacaaggca tcattcagga tgattaccgg attgaattta taaaagagca 590881 cctcaaatgg attcaccgcg ccatacagga aggctcgaac gtaaaaggct atcacttatg 590941 gacgttcatg gacaactggt cttggacaaa tgcctataaa aaccgatacg gatttgtatc 591001 agtcaatctt gagaaagacg gagaaagaac cgtcaaaaag agcggaaaat ggttcaaaga 591061 ggttgctgag catagcggtt tctagatttt cctaaaggtc aagatcttcc ggcaatcatc 591121 ataacgaata gagatgacga aaatccgcaa cattgatgaa atagggaaaa gaacttatga 591181 tatccgtaaa agcttatgtg atatcaaaca gctgccggag gataccaatg aataaatacg 591241 aaatcattgc aaatgaaatg agaaatagaa ttaaaaataa cgtatatccg atcgatcagc 591301 ccattcctga tgaagtatct cttgcaaaag aatttaactc aagccgcatg acgatgaaga 591361 gagccttgga taatttagtt gccgagggtc tgctgtttag aaaacgaggc catggcacgt 591421 ttattattca atctgcaata caggatgacc atgtccatgt agtcagcaat gagattctcg 591481 gattgaccaa cttgctgaaa gataaaaaaa tcaaaagcaa ggtcattcag tttgaagtgc 591541 aatttcccac tgaggaagtg gccgcccatt tgtctattga tcagaaaaca ccggtttatt 591601 atgtcgttcg gctgcgaatt gtagaaggtg aaccctatgt attagaaaaa acatatatgc 591661 cgactcattt aataccgggc attaatgacg atgtccttca tgattcgatc tacaatcata 591721 ttacaaatgt gctgcagctc aaaatcgccg gaacgcatcg gaaaatcaga gcctgcaaat 591781 ctgatcatat tgaccagcag catctgggct gtaaacagga tgatccaatt cttgaagtgg 591841 aacatgtggg cttcttagat accgggattc catttgaata ttccttttca cgtcatcggc 591901 atgacaagtt tgttgtgact tctgtaaaca tacggcgctg attgcggaga caacaaggag 591961 gccatctgca tgcttggcgg tattgaagca ggcggcacaa agtttgtttg tgctgtcggt 592021 agagaagatg gaacgatcat tgacaggata gaattcccca caaagatgcc ggatgaaacg 592081 atagagaaag taattcaata ttttagccaa ttttcattac aggcaatcgg catcggctcc 592141 tttggtcccg ttgataacga taaaaccagt caaacatacg gtaccattac ggccacgccg 592201 aaagcgggct ggagacacta tccctttttg caaaccgtta agaacgaaat gaagatccca 592261 gtcggattta gtacagatgt caacgctgcg gcgctgggtg aattcctttt cggtgaagcg 592321 aagggtcttg acagctgcct gtatataacg attggcactg gcatcggagc gggggctatt 592381 gtagagggga ggctccttca ggggctgtca cacccagaga tgggccatat ttatatccgg 592441 aggcacccgg atgacgtata ccaagggaag tgcccttatc atggagattg ctttgaaggc 592501 ttagcttcag gccccgctat cgaagcccgc tgggggaaaa aagccgcgga tttatcagat 592561 atagcacaag tctgggaact ggaagggtac tatattgccc aagcactggc tcagtatatt 592621 ttgatccttg cacctaaaaa aatcattctt ggcggcggcg tcatgcaaca gaaacaagtg 592681 ttttcttata tctatcaata tgtaccaaaa atcatgaaca gctacttaga tttttctgaa 592741 ttatcagatg atataagtga ttatattgta cctccacgtt taggcagtaa cgccggaatc 592801 atcggcacgc tagttttagc gcatcaggcc ttacaagcag aggcagcatc cggggaggtg 592861 cgatcatgac gcatccatta tttttagagc ctgtctttaa agaaagacta tggggaggga 592921 cgaagcttcg tgacgctttt ggctacgcaa taccctcaca aaaaacaggt gagtgctggg 592981 ccgtttctgc acatgcccat ggctcgtcgt ctgtaaaaaa tggcccgctg gcaggaaaga 593041 cacttgatca agtatggaaa gatcatccag agatattcgg gtttccggat ggtaaggtgt 593101 ttccgctgct ggtaaagctg ctggacgcca atatggatct ctccgtgcaa gtccatcctg 593161 atgatgatta tgcaaaactg cacgaaaatg gcgaccttgg taaaacggag tgctggtata 593221 tcattgattg caaagatgac gccgaactaa ttttgggaca tcatgcaagc acaaaggaag 593281 agttcaaaca acgaatagaa agcggtgatt ggaacgggct gctgaggcga atcaaaatca 593341 agccaggaga tttcttttat gtgccaagcg gtacactcca tgctttatgt aagggaaccc 593401 ttgtccttga aatccagcaa aactctgata caacatatcg cgtatacgat tatgaccgct 593461 gtaatgacca gggccaaaaa agaactcttc atatagaaaa agccatggaa gtcataacga 593521 taccgcatat cgataaagtg catacaccgg aagtaaaaga agttggtaac gctgagatca 593581 ttgtttatgt gcaatcagat tatttctcag tgtacaaatg gaagattagc ggccgagctg 593641 cttttccttc atatcaaacc tatttgctgg ggagtgttct gagcggatca ggacgaatca 593701 taaataatgg tattcagtat gaatgcaatg caggctcaca ctttattctg cctgcgcatt 593761 ttggagaatt tacaatagaa ggaacatgtg aattcatgat atctcatcct taatgaatgg 593821 gggagttgca tttgtttaag aaacatacga tctctttgct cattatattt ttacttgcgt 593881 ctgctgtttt agcaaaacca attgaagcgc atactgtgtc gcctgtgaat cctaatgccc 593941 agcagacaac aaaaacagtg atgaactggc ttgcgcacct gccgaaccga acggaaaaca 594001 gagtcctttc cggagcgttc ggaggttaca gccatgacac attttctatg gctgaggctg 594061 atagaatccg aagcgccacc gggcaatcgc ctgctattta tggctgcgat tatgccagag 594121 gatggcttga aacagcaaat attgaagatt caatagatgt aagctgcaac ggcgatttaa 594181 tgtcgtattg gaaaaatggc ggaattccgc aaatcagttt gcacctggcg aaccctgctt 594241 ttcagtcagg gcattttaaa acaccgatta caaatgatca gtataaaaaa atactagatt 594301 cttcaacagt agaaggaaag cggctaaatg ccatgctcag caaaattgct gacggacttc 594361 aagagttgga gaaccaaggt gtgcctgttc tgttcaggcc gctgcatgaa atgaacggcg 594421 aatggttttg gtggggactc acatcatata accaaaagga taatgaaaga atctctctat 594481 ataaacagct ctacaagaaa atctatcatt atatgaccga cacaagagga cttgatcatt 594541 tgatttgggt ttactctccc gacgccaacc gagattttaa aactgatttt tacccgggcg 594601 cgtcttacgt ggatattgtc ggattagatg cgtattttca agatgcctac tcgatcaatg 594661 gatacgatca gctaacagcg cttaataaac catttgcttt tacagaagtc ggcccgcaaa 594721 cagcaaacgg cagcttcgat tacagcctgt tcatcaatgc aataaaacaa aaatatccta 594781 aaaccattta ctttctggca tggaatgatg aatggagcgc agcagtaaac aagggtgctt 594841 cagctttata tcatgacagc tggacactca acaagggaga aatatggaat ggtgattctt 594901 taacgccaat cgttgagtga atccgtaatg tcacaattaa gaaggtgctc aagaagtttc 594961 ttgagcacct tcccactgga ttaagcattc atatcgccta acccaggact gtgttcattt 595021 ggtatttcag gaagcactgg tacgggaaac cctgccggag gatctattac ttgtaactct 595081 ccgccatttc ggcttggaga tttcccttga tagatttcac tgattctcgt ttcatccaac 595141 ctaaagttaa aatgtgtatt atggtagcct aattcgacat actttctgca ctcaggatat 595201 ttattaatgt cataattcgg cacagggagc agcttcgccc attcaacgcc caatgtctcg 595261 agcgctttcg cgaatgcatt ctggtgagca ttgtcgcgta caatcagaaa agcaagtgtt 595321 tcgcggaacg tctgattaga gctcatttca taaattcttg ttttttgcag cacacctgtc 595381 gactcaagaa gcaggttatc cagcaggtca gtaattaagt ttccgtggtt atacacccac 595441 gacccgttcc acggattgcc ccctgcatca acaggaaggg aactttgcgc tccaataata 595501 taatgatgag gattagcatg tttaaccgct tcatcaagtg gcgcttgatc tgtaccttga 595561 ctgccgacac cttcaccgcc tgattcatct aataaagcat tgattgtgtt ttgaaccagt 595621 tcaacgtggg caatctcctc taaaaaaatg ccgcgaagca gatcgcggta ctgtttctgc 595681 tttcctctga aattagagct ttggaaaaaa actgcatcat tgtacgcatt tctccgtaat 595741 gaccgcctaa tatctcctgc aggaccttag cagctgccgg gtctggcttg tccggtttaa 595801 tgatattaat cagttcctct ttgtagtaat acataacacg cctcatttct tcttaagaga 595861 ttttcttata ttatttgtaa gatgagataa aatatataca tgataagcat gggaaggcgt 595921 gaaagaagaa aataaaaaaa tacaggaaaa gtgttgacca aataaaacag gcatggtata 595981 ttattaaacg tcgctgatga acagcgtgaa acaaaacaga aaaacaaaaa agttttccta 596041 aggtgtttac aagattttaa aaatgtgtat aataagaaaa gtcgaattga aaaagattcg 596101 aaaaaacatt aaaaaacttc ttgacttcaa catcaaatga tagtatgata gttaagtcgc 596161 tcaataagcg cccgtagctc aattggatag agcgtttgac tacggatcaa aaggttaggg 596221 gttcgactcc tctcgggcgc gccatataag ataccacgcg ggtgtagttt agtggtaaaa 596281 cctcagcctt ccaagctgat gtcgtgagtt cgattctcat cacccgctcc attattgaat 596341 gatctttgaa aactaaacaa gacaaaacgt acctgttaat tcagtttttg aaaatcgcac 596401 agcgatgtgc gtagtcagtc aaactagggc ctgcacgatg caggtcacac aggtgtcacc 596461 gcgggatgcg gtggacttaa cctgtgatcc atttatcgga gagtttgatc ctggctcagg 596521 acgaacgctg gcggcgtgcc taatacatgc aagtcgagcg aacagatggg agcttgctcc 596581 ctgatgttag cggcggacgg gtgagtaaca cgtgggtaac ctgcctgtaa gactgggata 596641 actccgggaa accggggcta ataccggatg gttgtttgaa ccgcatggtt caaacataaa 596701 aggtggcttc ggctaccact tacagatgga cccgcggcgc attagctagt tggtgaggta 596761 atggctcacc aaggcaacga tgcgtagccg acctgagagg gtgatcggcc acactgggac 596821 tgagacacgg cccagactcc tacgggaggc agcagtaggg aatcttccgc aatggacgaa 596881 agtctgacgg agcaacgccg cgtgagtgat gaaggttttc ggatcgtaaa gctctgttgt 596941 tagggaagaa caagtaccgt tcgaataggg cggtaccttg acggtaccta accagaaagc 597001 cacggctaac tacgtgccag cagccgcggt aatacgtagg tggcaagcgt tgtccggaat 597061 tattgggcgt aaagggctcg caggcggttt cttaagtctg atgtgaaagc ccccggctca 597121 accggggagg gtcattggaa actgggaaac ttgagtgcag aagaggagag tggaattcca 597181 cgtgtagcgg tgaaatgcgt agagatgtgg aggaacacca gtggcgaagg cgactctctg 597241 gtctgtaact gacgctgagg agcgaaagcg tggggagcga acaggattag ataccctggt 597301 agtccacgcc gtaaacgatg agtgctaagt gttagggggt ttccgcccct tagtgctgca 597361 gctaacgcat taagcactcc gcctggggag tacggtcgca agactgaaac tcaaaggaat 597421 tgacgggggc ccgcacaagc ggtggagcat gtggtttaat tcgaagcaac gcgaagaacc 597481 ttaccaggtc ttgacatcct ctgacaatcc tagagatagg acgtcccctt cgggggcaga 597541 gtgacaggtg gtgcatggtt gtcgtcagct cgtgtcgtga gatgttgggt taagtcccgc 597601 aacgagcgca acccttgatc ttagttgcca gcattcagtt gggcactcta aggtgactgc 597661 cggtgacaaa ccggaggaag gtggggatga cgtcaaatca tcatgcccct tatgacctgg 597721 gctacacacg tgctacaatg gacagaacaa agggcagcga aaccgcgagg ttaagccaat 597781 cccacaaatc tgttctcagt tcggatcgca gtctgcaact cgactgcgtg aagctggaat 597841 cgctagtaat cgcggatcag catgccgcgg tgaatacgtt cccgggcctt gtacacaccg 597901 cccgtcacac cacgagagtt tgtaacaccc gaagtcggtg aggtaacctt ttaggagcca 597961 gccgccgaag gtgggacaga tgattggggt gaagtcgtaa caaggtagcc gtatcggaag 598021 gtgcggctgg atcacctcct ttctaaggat attatacgga atataagacc ttgggtctta 598081 taaacagaac gttccctgtc ttgtttagtt ttgaaggatc attccttcga aacgtgttct 598141 ttgaaaacta gataacagta gacatcacat tcaattagta atacaagata tcacatagtg 598201 attcttttta acggttaagt tagaaagggc gcacggtgga tgccttggca ctaggagccg 598261 atgaaggacg ggacgaacac cgatatgctt cggggagctg taagcaagct ttgatccgga 598321 gatttccgaa tggggaaacc caccactcgt aatggagtgg tatccatatc tgaattcata 598381 ggatatgaga aggcagaccc ggggaactga aacatctaag tacccggagg aagagaaagc 598441 aaatgcgatt ccctgagtag cggcgagcga aacgggatta gcccaaacca agaggcttgc 598501 ctcttggggt tgtaggacac tctgtacgga gttacaaagg aacgaggtag atgaagaggt 598561 ctggaaaggc ccgccatagg aggtaacagc cctgtagtca aaacttcgtt ctctcctgag 598621 tggatcctga gtacggcgga acacgtgaaa ttccgtcgga atccgggagg accatctccc 598681 aaggctaaat actccctagt gaccgatagt gaaccagtac cgtgagggaa aggtgaaaag 598741 caccccggaa ggggagtgaa agagatcctg aaaccgtgtg cctacaagta gtcagagccc 598801 gttaacgggt gatggcgtgc cttttgtaga atgaaccggc gagttacgat cccgtgcaag 598861 gttaagcaga agatgcggag ccgcagcgaa agcgagtctg aatagggcgc atgagtacgt 598921 ggtcgtagac ccgaaaccag gtgatctacc catgtccagg gtgaagttca ggtaacactg 598981 aatggaggcc cgaacccacg cacgttgaaa agtgcgggga tgaggtgtgg gtaggggtga 599041 aatgccaatc gaacctggag atagctggtt ctctccgaaa tagctttagg gctagcctca 599101 aggtaagagt cttggaggta gagcactgat tggactaggg gcccctaccg ggttaccgaa 599161 ttcagtcaaa ctccgaatgc caatgactta tccttgggag tcagactgcg agtgataaga 599221 tccgtagtcg aaagggaaac agcccagacc gccagctaag gtcccaaagt atacgttaag 599281 tggaaaagga tgtggagttg cttagacaac caggatgttg gcttagaagc agccaccatt 599341 taaagagtgc gtaatagctc actggtcgag tgactctgcg ccgaaaatgt accggggcta 599401 aacgtatcac cgaagctgcg gactgttctt cgaacagtgg taggagagcg ttctaagggc 599461 tgtgaagcca gaccggaagg actggtggag cgcttagaag tgagaatgcc ggtatgagta 599521 gcgaaagagg ggtgagaatc ccctccaccg aatgcctaag gtttcctgag gaaggctcgt 599581 ccgctcaggg ttagtcggga cctaagccga ggccgaaagg cgtaggcgat ggacaacagg 599641 ttgatattcc tgtaccacct cctcaccatt tgagcaatgg ggggacgcag gaggataggg 599701 taagcgcggt attggatatc cgcgtccaag cagttaggct gggaaatagg caaatccgtt 599761 tcccataagg ctgagctgtg atggcgagcg aaatatagta gcgaagttcc tgattccaca 599821 ctgccaagaa aagcctctag cgaggtgaga ggtgcccgta ccgcaaaccg acacaggtag 599881 gcgaggagag aatcctaagg tgatcgagag aactctcgtt aaggaactcg gcaaaatgac 599941 cccgtaactt cgggagaagg ggtgctctgt tagggtgcaa gcccgagaga gccgcagtga 600001 ataggcccag gcgactgttt agcaaaaaca caggtctctg cgaagccgta aggcgaagta 600061 taggggctga cgcctgcccg gtgctggaag gttaagagga gcgcttagcg taagcgaagg 600121 tgcgaattga agccccagta aacggcggcc gtaactataa cggtcctaag gtagcgaaat 600181 tccttgtcgg gtaagttccg acccgcacga aaggcgcaac gatctgggca ctgtctcaac 600241 gagagactcg gtgaaattat agtacctgtg aagatgcagg ttacccgcga caggacggaa 600301 agaccccgtg gagctttact gcagcctgat attgaatgtt ggtacagctt gtacaggata 600361 ggtaggagcc ttggaaaccg gagcgccagc ttcggtggag gcatcggtgg gatactaccc 600421 tggctgtatt gaccttctaa cccgccgccc ttatcgggcg gggagacagt gtcaggtggg 600481 cagtttgact ggggcggtcg cctcctaaaa ggtaacggag gcgcccaaag gttccctcag 600541 aatggttgga aatcattcgc agagtgtaaa ggcacaaggg agcttgactg cgagacctac 600601 aagtcgagca gggacgaaag tcgggcttag tgatccggtg gttccgcatg gaagggccat 600661 cgctcaacgg ataaaagcta ccccggggat aacaggctta tctcccccaa gagtccacat 600721 cgacggggag gtttggcacc tcgatgtcgg ctcatcgcat cctggggctg tagtcggtcc 600781 caagggttgg gctgttcgcc cattaaagcg gtacgcgagc tgggttcaga acgtcgtgag 600841 acagttcggt ccctatccgt cgcgggcgca ggaaatttga gaggagctgt ccttagtacg 600901 agaggaccgg gatggacgca ccgctggtgt accagttgtt ctgccaaggg catcgctggg 600961 tagctatgtg cggacgggat aagtgctgaa agcatctaag catgaagccc ccctcaagat 601021 gagatttccc attccgcaag gaagtaagat ccctgaaaga tgatcaggtt gataggtctg 601081 aggtggaagt gtggcgacac atggagctga cagatactaa tcgatcgagg acttaaccat 601141 atttttgaat gatgtcacac ctgttatcta gttttgagag aacactctca atttgtttgg 601201 tggcgatagc gaagaggtca cacccgttcc cataccgaac acggaagtta agctcttcag 601261 cgccgatggt agtcgggggt ttccccctgt gagagtagga cgccgccaag cattactttt 601321 atcatcgcgg ggtggagcag ttcggtagct cgtcgggctc ataacccgaa ggtcgcaggt 601381 tcaaatcctg cccccgcaac caaatatatg gttaaataag gagtgcccta agggtgcaac 601441 caaaataatc ctatacaaat atggtccggt agttcagttg gttagaatgc ctgcctgtca 601501 cgcaggaggt cgcgggttcg agtcccgtcc ggaccgccat taatgtaaac gaaacgatca 601561 tgttttcgtt ttttttgtgt tttcttttac tgtatcttct gcttggtgtc atagccaagc 601621 tttctttata tcgggaacat cttggatatt ccagcaaaat tcgataaact aggaagagca 601681 caaataggca taagcagggt tgaaaggagg ttttggttca tggatgaatt tgatttgata 601741 catagcatta ctccgcggac cattcaccat tcttccgttg atgtaggaat aggtgatgat 601801 gcagcgctct acactgcgaa acacggcgtt caggaaattg tttgtgttga tactatggta 601861 gaagacgtgc acttcaaatt acactattcc tcacctgaag atatcgggta caaggcgtta 601921 gccgttaata taagtgatat tgccgcgatg ggaggcattc ctaagtttta tctggtatca 601981 cttgcggtac cttcaaaatg gactgaatct gaaatcaagg cgatgtatga aggaatgaat 602041 gaactggcga aactatatca tatggatctg attggcggcg atacagtttc taccgctgac 602101 aaattagtcg ttacagtcac tgtaatcggt gaaattgaaa agggacaggc ctgtttgcgc 602161 agcttggcaa aaccgaatga tattgtgttt gtaaccggtg aaatcggttc ttctgcagca 602221 gggctttctt tattgctgga agagactaat cctcaaaact catctgtgga aacggattac 602281 tttatccaca ggcataaacg gcctgagcca agagtaagcg tcggcagatt atgctcgatt 602341 tttaaacggg cagctttaaa tgatgttagt gacggattgg ctagtgaact gaacgagatt 602401 gcagaagcca gctgtgtttc aattgaaatt gttgaaagca tgcttccaat tcattctgat 602461 ttgcctaagc ttcatcctaa ctggaaagaa tgggctttgt ttggcggtga ggattttgag 602521 ctgacaggga cggtttcaaa tgaggagtgg gaagtgttga agcaggagtg cgcagcgctt 602581 catcttccca ttacaaagat tggctatgtc agggaaaaaa caaaatctaa agtgatccta 602641 aaaacagatc aaacatcaat gatcttagag aaaaagggat ataatcattt taaataagac 602701 gggtgactcg tgtgaagcaa ttaaaatgga gaactgtaaa tccagaagaa acaaaagcaa 602761 ttgccaagct gacggcagcg tttgctaaac cgggagacgt cctgacatta gagggcgatt 602821 taggtgcagg aaaaacgact tttacgaaag gttttgcaga agggctggga attacacgta 602881 ttgtaaacag tccgactttt acaattataa aagaatataa cgatggcgta cttcctcttt 602941 atcacatgga tgtgtataga atggaagatg aaagtgaaga tttgggactt gatgaatatt 603001 ttcacggaca aggtgtctgt ctcgttgaat gggctcattt aattgaagaa cagctgccac 603061 aggagcgact gcaaattgtc atcaaaagag ctggtgatga tgagcgggaa attaccttta 603121 ctgctgtcgg gaatcggtat gaaatgcttt gtgaggagtt aagtagacat gacaatatta 603181 gcaattgata catcaaatta tacattgggc attgcgctgc ttcgagaaga cactgttata 603241 gcagaataca ttacatattt gaaaaagaac cactctgtaa gagcgatgcc tgctgttcat 603301 tcattgctga atgattgtga tatggcaccg caggaccttt ctaaaattgt cgttgcaaaa 603361 ggccctggtt catacacagg agtaagaata ggtgtgacgt tggccaaaac acttgcctgg 603421 tctttagaca ttccaataag tgctgtatca agtcttgaga cgcttgcggc aaatggccgg 603481 cattttgacg gtctgatcag cccaatcttt gatgctagac ggggacaggt gtacacaggt 603541 ctgtatcaat ataaaaatgg gcttttagag caagttgttc cagatcaaaa tgtgatgctg 603601 gcagattggc tggagatgct aaaagaaaag gaccgccctg ttttgttttt aggccatgat 603661 acttctcttc acaagcagat gatcgaggat gtgcttggaa caaaaggatt cattggaact 603721 gccgcccagc ataacccgcg cccttcagaa ttggcttttc tcgggaagga aaaggaagca 603781 gctgatgttc atgggcttgt cccggattac ttgcggctgg cagaagctga agcgaaatgg 603841 attgaaagtc aaaagtaggg tgataggatg aaaacaaaag cagcggtcag aaatatgcgg 603901 cttgaagata tagatcacgt atacgaaatc gaagcatcct cctttacgtc tccttggacg 603961 aaggattcgt tttatcatga gctgctggaa aatccgtatg ctcattatct cgtgattgaa 604021 aaggacggcc atcttgctgg gtattgcggg atttggattg tgatggacga tgcccagatt 604081 acaaatatag cgataaaacc agagtatcgc ggccagtctt taggagaaac gctttttcgc 604141 tcagctgttg aactgtgcaa agaaaaagac gcaaggcggc tttcgcttga agtgagggtt 604201 tcgaatcatc ctgctcaagg cttatataag aaattcggga tgcagcccgg cggaataaga 604261 aagaactatt atactgataa cggggaagat gcgttaatta tgtgggtgac gataaatgag 604321 tgagcaaaaa gacatgtacg tattaggaat tgaaacaagc tgtgatgaga ctgctgcagc 604381 tattgtgaaa aacgggaaag agatcatttc aaacgtagta gcctctcaaa ttgaaagcca 604441 taagcgcttc ggaggcgttg ttccggaaat tgcttcaaga catcatgttg aacaaatcac 604501 tttggttata gaagaggcgt ttcgcaaagc tggcatgacg tatagtgata ttgatgcgat 604561 tgcagtaaca gaaggtccgg gactggtggg agcgcttctt atcggagtga atgccgctaa 604621 agcattgagc tttgcatata acattccgtt agtaggcgtt catcatatag ccggtcatat 604681 atacgcgaac cgtcttgtag aagacatcgt gttcccggca ctggcattgg tcgtttcagg 604741 aggccataca gaactggttt atatgaagga acatggatca tttgaagtca ttggggaaac 604801 ccttgatgat gcggcaggag aagcctacga caaagtggcg cggacgatgg gattgccata 604861 tccgggtgga ccgcaaattg acaagctagc tgaaaaaggg aatgacaata ttccgcttcc 604921 tcgcgcatgg cttgaagaag gctcttacaa cttcagcttt agcggattga agtctgcggt 604981 gatcaatacg cttcataatg catcccaaaa agggcaagag attgctccgg aagatttgtc 605041 tgccagtttc caaaatagtg tgatcgatgt cttggtaacc aaaacggcgc gcgcggcaaa 605101 ggaatatgat gtcaaacagg tccttttagc cggaggagta gctgcaaaca gaggcctcag 605161 agctgcatta gaaaaggaat ttgcccagca tgaagggatt acgcttgtca ttcctccatt 605221 agctttatgc acggataatg ctgcgatgat tgctgctgct ggtacaattg cttttgaaaa 605281 aggaattcgc ggtgcatatg atatgaatgg ccagcccggc cttgaattga cttcttatca 605341 aagtctcacg agataatagc gtgagacttt ttatctgttt gttattaaca gacaattcac 605401 aatttatcca catatctgtg agtaattata gagatattga tggataaagg gctgaggtca 605461 ctgttaataa agtggataaa ttcagaatat tttgtggata gtgtgtataa agcgcttact 605521 ttgtttattt attaggggat gttctgtgga taaaaagcac ctctaaaaag aggtgcttga 605581 cttttttaat cttcttctgt ggatagttct tcccattcgg acaaaagaga ttccagctcc 605641 tgattaagct tctcattgtc tgcatggata gcttgtactt tttcatgatc ctgatagact 605701 tcagggtcac atagcaattc atcattgcgg ctgatgttct cctcaatggt ttgaacggtg 605761 gtttcaattt cttcaatccg acggagtcgt tggcgctctt tctttttcca ttctttttct 605821 tcctcgtagg aacgtttgga gtcagacttc actgtagctg gcgttttatc agtttcctct 605881 tgctgattca ttttctccaa ttcaagctgc tctgtttttt tctctgtata ataatcgtaa 605941 tctcccagat actcctctat atggcttgaa gaaagctcca atactcttgt ggcgattctg 606001 ttaataaaat atctgtcatg tgagacaaat aacagtgtgc ctggataatc aatcagcgcg 606061 ttttcgagaa cttctttgct gtctaaatcc agatggttcg tcggttcatc aaggatgaga 606121 aagttggctt tttgaagcat cagcttagct agagccaatc ttgctttttc gcctccgctc 606181 agtgaatgaa ctggtttcag cacatcatct ccggagaata agaaatttcc gagacacgtt 606241 ctgatttctt tttctgggag cccggggtac tcgtcccaca gctcatcaag gacacgttta 606301 gaggaagtca actcagcctg ttcctggtca taatagccga cactgacatt tgagccgtaa 606361 gaaattgttc cctgatctgg ttttagggtg tctattaatg ttttcagcaa tgtcgattta 606421 cctattccgt tagggccgac aagcgcagcg ctttctcctc ttgtgagcat gaatgacact 606481 tctgttaaaa gcggcggctg gttttcatag ctgattgtga gatcctgaac acgaaggact 606541 tcatttccgc tctgttttgt aatatcaaaa tgaaagtttg cggatttttc atcgccaagc 606601 ggttttgaca tgacatccat tcgctcaagc tgctttctgc ggctttgcgc ccttttggtg 606661 gtagaggctc tcgccagatt tcgatctacg aagtcctgca gctttgcaat ctcgtcctgc 606721 tgcttttcat acattttcag atctttttca tactgcgcgg ctttttggtc gagataagcg 606781 ctgtagttgc cgtgatactt tttgctttct gctcttgata cctcgtatac ctggtttact 606841 actttgtcca aaaagtagcg gtcatgcgaa acgatgagaa tggcgcctga atagccttgt 606901 aaataatgct caagccaggt aagcgtatca atatccagat ggtttgtcgg ctcatcaaga 606961 atgagcaaat caggctgtgt taatagaagc ttacctaaag ccagtcttgt tttctggcct 607021 ccgctgaggc tttgaacctg tgtagaatcg tcaaaatggc tgaagccgag accatgcagc 607081 acagatctaa catccgcttc atattgataa ccgcctttat ctttgaattc ctgctgaaga 607141 cggtcgtagg ttttcatgat gctttctaat tcacccgggt cagctgccgc cattttttct 607201 tccatagccc gcatttcctt ttccattgct tttaagtggt caaaaacagt cagcagctct 607261 tcttttatgg taagcttaga atccaagcca gtatgctggg cgagatatcc cattgtaata 607321 tctttcggtt taataatttc gcccttttca tacgaaagct ggcctgcgat aattttaagg 607381 agcgtggatt ttccggcgcc atttcttcct acaatggcga tgcgatcacg atttctgact 607441 tccagcttta tattgtttaa aatagtatca gcaccaaatg atttggacag ctgattaact 607501 tgtaagatca tcatattatt tcacctctgc tataataagt taagtgtagc ttatgaacca 607561 gaagtcagca aacaatacat tggccatata agacatagag aagaaaatag tgtatgatct 607621 gtttaaggag cgttttaata tgaatggatt ttctcatttt aatgaacagg gcagagccca 607681 gatggtggat attagcgaaa aatcttcgac tgtccgtact gcggcggctg tttcaagcgt 607741 acacatgaag aatgaagtgt acgagaaaat acaaagtcac gatatcggca aaggagatgt 607801 actggctgtc gcacaggtgg caggcattat ggccgcaaag caaacgtcga atatcattcc 607861 gatgtgccat ccgctttcat tgagcggggt agatatatcg tttgactgga aaataaaaga 607921 agcagaagtt atacttcata taaaagcaca ggtcaaaacg aaagggagta caggtgtgga 607981 aatggaagcg ctcacttctg catcggtgtg cgctcttacc gtttacgata tgtgcaaggc 608041 ccttgataag ggaatggtca tcggccctac tttcttgctg gagaagacag gcgggaaaaa 608101 cggtgacttt aaaagagaac tatccgagta taatttggag gaccaaaaat gaataaggat 608161 caatcaaaaa ttccgcaggc gacggcgaaa cggctgccgc tttactatcg ctttttaaag 608221 aatctgcatg cgtcaggaaa acagcgtgta tcatccgctg aactcagtga tgccgtaaag 608281 gttgattctg ccacgattcg gagggatttt tcctattttg gagctcttgg caaaaaagga 608341 tacggatata atgtggatta tttgctgtct tttttccgga aaacgcttga tcaggatgag 608401 atgacagacg tcatcttgat tggtgtcggg aacttgggaa cggcatttct tcactataat 608461 ttcacaaaaa acaataacac aaaaatttct atggcttttg atataaatga gagtaaaata 608521 ggaactgagg taggcggcgt gcccgtctat aaccttgatg accttgaaca acacgtaaaa 608581 gatgaatcag ttgccattct tacagtgcca gcagttgccg ctcaatccat tacagacaga 608641 ttggtcgcat taggaatcaa gggaatcctt aattttacgc cggcccgttt gaatgtgccg 608701 gaacacattc gaattcatca tatagattta gcagttgagc ttcagtcact ggtttatttt 608761 ttgaagcatt attcagtttt agaggaaatc gaatagaggg aaaggaggag cccaaatatg 608821 ccgatcggtc ctggaagcct tgctgttatc gcaatcgttg ctctgattat cttcggtccc 608881 aaaaagctgc ctgaattggg gaaagcagcg ggagacacac ttcgtgaatt taaaaacgct 608941 actaaaggat taacgagtga tgaagaggaa aaaaagaaag aagatcagta agttaggatg 609001 acacgaatga aagtgaatca aatgtcgctg ctggagcata ttgctgagct tcgaaaacgg 609061 ttgctgattg tagcgctggc gtttgtcgtt ttctttattg ctggattttt tttagcaaag 609121 ccgattattg tgtatctgca agaaacagat gaagcgaagc agcttacgct taacgcgttt 609181 aacctgacag acccgcttta tgtgtttatg caatttgcgt ttatcatcgg catagtcttg 609241 acctcgccgg ttattcttta tcagctttgg gcttttgtga gcccgggcct ctatgagaaa 609301 gagcgcaaag taacgctcag ctacattccg gtctctattt tgctgttttt agcgggctta 609361 tctttttcat attatatttt atttcctttt gttgttgatt ttatgaagcg gatttctcag 609421 gacttgaatg tcaatcaggt gatcggaatt aatgaatatt ttcattttct tctgcagctg 609481 acgattccgt ttggactgct gttccaaatg ccggtcatcc tcatgttttt gacaaggctc 609541 ggaattgtga caccgatgtt cttggcgaaa atcagaaagt atgcgtattt tacgctgctg 609601 gtgatcgcag ccctgattac accgcctgag cttctgtccc atatgatggt cacagtcccg 609661 cttttgattt tatatgaaat cagtatcctt atatcgaagg ccgcttatcg gaaagcacag 609721 aaaagcagtg ctgccgatcg ggacgtgtct tctgggcaat aataaaaaat ccatttctca 609781 tgcgagaaat ggattttctt tatttttggt tctttttgat tttaaatgaa aaggcgaaca 609841 tcttaaaaga aatgctgatg ttgtaagcgg cgaacaccat cagcaggatg gagtaaaatg 609901 accacatgct gcctggcgag cttgcggcaa gataagtaaa gatgcaccct acggcaaagt 609961 agatcattcc ccaaactacc gggtttctca taaaaataat cctccaataa tcaattgcat 610021 ttgtgtgctc tgctgttcaa ggtaattacg aacaggctca agctgcatga tgacgacgaa 610081 tgtattcatc attaaatggg cgaaaatcgg cacccatatc cgttttgttc tcgcatataa 610141 aaaggcaaag gtaaagccca ttgctgtata tagaaggaga tgcttcaaat cagcgtgaac 610201 aataccgaag ataaccgagc tgatcagtcc tgcgaaaaag aaattcgttt tttcgtacag 610261 cgcgccgaaa atgatttttc tgaagatgat ttcttctaat ataggcccga cgatggaaga 610321 aacgataatc atgagcggga ctgcctgaat gacatccaga atcgcttgtg tattttctga 610381 ttctcttccg atgccaaaaa cataatattc aatagagcct gctattcctt gagagaaaag 610441 ggcaatgaaa aaaccggcta tcgcccaaag gatagaaagt ccgattgagt ccttctgtcc 610501 gtttcgcagc gtttctttcg gaacggttct cagaatgagc agaacaacaa cgagacaggc 610561 gataaagctg ataacggacc ataatccttg tgcatgcagc atattttcat ctgtaggctg 610621 tcctccggca taaccgaatt taaataacaa gggaatcgcg attaatgcgg aaaactgcat 610681 gatgatatat gtcaaaataa taaaccaata ctgttttctc aaatggtatg tactcctttg 610741 ttaagtgggt ttcgttcatc tacagctatt gtaacataat cggtacgggg gtgaaaaagc 610801 taacggaaaa gggagcggaa aagaatgatg taagcgtgaa aaatttttta tcttatcact 610861 tgaaattgga agggagattc tttattataa gaattgtgtt agcactcttt agtgctgagt 610921 gctaaaatta catattcata ctattgagga ggttatttca ttgttaaagc cattaggtga 610981 tcgcgttgtc attgaactcg tagaatctga agaaaaaact gccagcggaa ttgtgttgcc 611041 ggattctgca aaagaaaaac cgcaagaagg caaaatcgtg gcagctggtt caggtcgcgt 611101 gttagaaagc ggagagcgcg ttgctttaga agtaaaagag ggcgaccgca ttatcttctc 611161 aaaatacgca ggtactgaag tgaaatacga aggtactgaa tacttaatct tacgtgaaag 611221 cgacatttta gctgttatcg gctaattctt aaataaacaa tacttaaaac atttgaggag 611281 gtcttgtaaa catggcaaaa gaaattaagt ttagtgaaga agctcgccgc gcaatgcttc 611341 gcggtgtcga tgcacttgct gatgctgtta aagtaacttt aggaccaaaa ggacgcaacg 611401 tggttctaga gaaaaaattc ggttctccgt taatcacaaa tgacggtgta acaatcgcta 611461 aagaaatcga gctagaagac gcgtttgaaa acatgggtgc taagcttgtt gctgaagtag 611521 ccagcaaaac aaacgacgtt gccggtgacg gtacaacaac tgcaacagtt cttgcgcaag 611581 caatgatccg tgaaggcctt aaaaacgtaa cagcaggcgc taaccctgta ggcgtgcgta 611641 aagggatgga acaagctgta gcggttgcga tcgaaaactt aaaagaaatt tctaagccaa 611701 tcgaaggcaa agagtctatc gctcaggttg ctgcgatctc tgctgctgat gaggaagtcg 611761 gaagccttat cgctgaagca atggagcgcg taggaaacga cggcgttatc acaatcgaag 611821 agtctaaagg cttcacaact gagcttgaag ttgttgaagg tatgcaattc gaccgcggat 611881 atgcgtctcc ttacatggta actgactctg ataagatgga agcggttctt gacaatcctt 611941 acatcttaat cacagacaaa aaaatcacaa acattcaaga aatccttcct gtgcttgagc 612001 aggttgttca gcaaggcaaa ccattgcttc tgatcgctga ggatgttgaa ggcgaagcac 612061 ttgctacact tgttgtgaac aaacttcgcg gcacattcaa cgcagtggct gttaaagctc 612121 ctggtttcgg tgatcgccgt aaagcaatgc ttgaagacat cgctgtcctt actggcggag 612181 aagtcatcac agaagatctt ggccttgacc tgaaatctac tcaaatcgct caattgggac 612241 gcgcttctaa agttgtcgtt actaaagaaa acacaacaat cgttgaaggc gctggcgaaa 612301 cagacaaaat ttctgcccgt gtgactcaaa tccgcgctca agtggaagaa acaacttctg 612361 aattcgacag agaaaaatta caagagcgtc ttgctaaact tgctggcggc gtagctgtca 612421 tcaaagtcgg cgctgcgact gaaactgagc tgaaagagcg taaacttcgc atcgaagacg 612481 ccttgaactc aactcgcgca gctgttgaag aaggcatcgt atccggtggt ggtacagcgc 612541 ttgtaaacgt atataacaaa gtcgctgcag ttgaagctga aggcgatgct caaacaggta 612601 tcaacatcgt gcttcgcgcg cttgaagagc caatccgtca aatcgcacac aacgctggcc 612661 ttgaaggatc tgtcatcgtt gagcgcctca aaaacgaaga aatcggcgta ggcttcaacg 612721 ctgcaactgg cgaatgggta aacatgatcg aaaaaggtat cgttgaccca acaaaagtta 612781 cacgctcagc tcttcaaaac gctgcgtctg tagctgcaat gttcttaaca acagaagctg 612841 ttgtcgctga caagccagaa gaaaacggtg gcggcgcagg aatgcctgat atgggcggca 612901 tgggcggtat gggtggaatg atgtaataaa gggatattaa cccttataca tcaatgtttt 612961 aaccgtctta aaaaactaga caaagcgtga ataaaaaaag agaaggtctt tcatcagttt 613021 actaaactgt tgggagacct tttctccata ttagcggtca tatgagcata aatgtccatc 613081 gtcgtattta tgtccgaatg accaaattgt tgctggattt ctttaatgcc tactcctgcc 613141 tcaattagta aggaggtatg ggtatgccta aaagagtggg gggtgacatt ctttttatcc 613201 cagctttttt gagcagccgt ttaagtctag tctcaataac ctttcttaat tgcggatgac 613261 catcctcccg ctcaaaaata aatgatgagt cttgataaat caatctattt ttaagcttaa 613321 tttcattttg ataaatttta ttttttttta gtagattgac atcgtttcat caattcgaac 613381 gatatcaaca gatcctgttg ttttaggtgt tagcaattgg tatttttcaa tttgattgtt 613441 aggggtgtat agggtctttg tgacctggct tatcattgaa atctgtccat tttaaagcaa 613501 gaagttcacc aattcttagg tcggtctagg caagtacggt aaagaccaaa tggtccattt 613561 ctagcccgtc agattgagcg agctttagaa aatgtgtcag cacctctttt tccaatgctt 613621 tgttgcttct tgggtaattg aaaatcccca gttgggttca ttttaataat cccttgagtt 613681 ttagcttttc ggaaaatcat acggccgcag gcatgaatac ctcccaaaca attgtgactg 613741 tattgctcgt tcagttctaa cgtgcggtct tcatacattt ttttgtgttt tgctaatcgg 613801 gtattgaccc aatactgcga taaaatgcat cattttcttt tcactggccc gtacactgct 613861 tatttttacc ccactccggt tgtaaatctt aagccaacct tttgcaaatg ttttgaaggg 613921 catatctgac tccttaataa aagtcccgtt gtcgttttgg agttctacgt gacgggctgc 613981 tactggggct tctttctttg ttttaaatct tcctttggat atttctagac gttttttggt 614041 taaagggtca atgcctagta gatatgataa ctccacgtct taccgcattg cttgagtttt 614101 gccatttatt tgtccctaac taattttttt tcatcaaatt ggtctttaag tgagtttaat 614161 aatttttgtt tctctcgact ggtcaataat tgcccttcat atttcaaaag attggataaa 614221 tttgagatgg aatcaatcct gatggatggt accgtagact ttaataagaa acgaaaggcc 614281 aactgcgact tcagttggcc tttcctattt ataataaaga aattgagtga gattgctgac 614341 agaactacgt actactcgtt ttctttagtt gcccttgcta atcgttcaac ctctccccga 614401 atcccaatcg caggctccca cgaatcaatc aaacgaatcg ccttctgatt agattccacc 614461 gctttcgttt tctctccttt acgatacaac agctgcgcca ttccgtagtg atagtagatc 614521 agttcaactt gattggcgtt atgtttgtca tagagcattt gctcaaaggc ttcttccgct 614581 ttttcaaact gatcacattt cacgtaagcg acacccagat tgaaataggc ttctatcgtt 614641 ttttcgccgc cgtatgtgga gctgatttca tttgccgctt cgtataattg aatggcttct 614701 acatgataac ctctcgcaaa gcttaagtca ccgcgaacca atagaactct gtgttgaatg 614761 gtaggggaaa tcggttgatt ttcgatttcg tttaaaattg tctctgcttt ttcctgttgc 614821 ccgtctttta aaaacagcct tgctttgagt gcatgtcccc aaacctttag atcataggca 614881 tcgtgagcgt ctgattgttc aagaatcttc agcccggctt ctatttgctg aagcgctccg 614941 tctaaatcat tgacttccat caatgcccag cctgaggtgt cgattcggaa gtacgcttct 615001 cgtgtgtgtt ggcctaagtg atgggcggcg tcggccgctt tgcgtccgta ttcgattcgc 615061 aggggcaggt tgattctgct tagaaaatgg ctaatgcggg tgatgagttc gattaggatt 615121 tctttttgtt cagtttcact tgcccattgg atgaccttta agatgtttgg ccattcttgt 615181 ttcatttgat ctaagttccg tcccagcagg tagctccaat agatagagtt gggctgttcc 615241 cgctttaaat gggtttcggc ataatcaata taatagtgcg cccagcgatt gcgggcttct 615301 ttttcatatt cgtgctgttc ggacaagtgc tgttctccgt aagcgacaac ggtttggtgc 615361 gctaagtatt gtgtcctgcc ttggcttcgt tccggctgaa tcagcgcata tgaccgcatt 615421 tgttccatag cgtaatgaaa acggcgggcg tctaatccgg ctgctgccgc caggcttttt 615481 tcatcaggcg gcttgctgaa aaagcaaagc gtctgccaga gctttcgcgt atcttcattg 615541 catctatccc aggtgcggcc aaagaggaat tcaaacaatt ccagcagtga gtagcctgct 615601 tttccaagct catgaatcag ctgctgagcg gggatgtcat cgtctgacat ataggcaatg 615661 ctgagtgcca tggctttcgg gtttccggca gtcgctgaaa tgaattcgtt tttcaggtca 615721 gatgatagat gtaacagctg ctccagcttt tcccgtttac gtgggaggtt gcatgtttgt 615781 aagcagtgat gcacttcttg ttgaaaaaat tcgtgggcat ctgtttggtc aagaccgctt 615841 agctgaatgg ctgtcatttc tccgaagctt tcccgataag tttgctttac gttttcccgc 615901 gctgtaagga gaacttttac gccttgcgga aggctggtga taaattcatg aatgtcacgt 615961 tctgcagtat caatgctgtc aacgatcagc aggatcggtt tttctctagt gtaattggct 616021 aacgcattgc ggacgacaaa ccgttttaca ttgattgatt tatcgatttg ttctttgcgt 616081 ccgagctgat aggcgatcgt atttaaaaaa tcgctaaagc ttaatccttt ccaatcagcg 616141 ctgacccaga tgatgctgtt gaatgccggc caaactgaag tatcgtcgac acaggaatag 616201 gcggcttcaa gagcaattgt ggtttttccc atgccggccc agccggtgat taaacagact 616261 ggtgatggag aaagcatcca ttgccgtatc gcttccatat caaagctgcg tccgataaag 616321 cgtccggacc agcgtgaggg taaattatgc gtgatgggct gttctgtaag cgcattcgtt 616381 tcttggccgg gtctgtcatg aaacagccgt tttactacat tttcaatttc gccttcactc 616441 ggagccccga ataatccgtc ttttcgcagt attttcgctt ttttcaaaca ggatgctgcc 616501 catacaggca atgcgggttt gatgactggg atagtggtgg cttccagcaa gtcggtcaac 616561 cactcgatat ccaagtcggt cttttcgaga atgatccaga tcattccgaa cagttttccg 616621 tcgtcgattc ttccgggaat gtagtttgcc cccatctgtc cgatccagct tttgatcgtg 616681 tttggggaga ctcccagctg gagtgcgatt ttatctatgt aagactgtcc tgttttttca 616741 ttctttttcc ttctgacttt ataatcagga tgaagtttta gcgttttgac gccaggtgcc 616801 agcatttgtg caaattgttt tcggttttca agttcagcca taagcctgca cctcctatta 616861 gtactatttt atcaatccag cgttttttgt atatgaaaaa ataaaagtac agtgccgctg 616921 tccttttata cagcaggaaa ggctgttgaa cgtgttaaaa agcagataaa atgggggcag 616981 taacagagaa aacaaaaatg tatgcactta cattttattt tctaaagaaa ggaacttgcc 617041 aaatgactca cacagtacct caaaacatga aagcggctgt tatgcacaac acaagagaga 617101 tcaaaattga aacattgcct gtgcctgata tcaatcatga tgaagtgttg attaaggtga 617161 tggctgtcgg aatttgcgga tctgatctgc attactatac aaatggccga ataggcaact 617221 atgttgtgga aaaaccattt atccttgggc atgaatgtgc gggtgaaatt gccgctgtcg 617281 gatcatctgt cgatcaattc aaggtgggag accgcgtcgc tgtagagccg ggtgttacgt 617341 gcggacgctg tgaggcgtgc aaagaaggac gctataatct ttgcccggat gtacagtttt 617401 tggctacacc gccggtagac ggtgcgtttg tccaatatat taaaatgcgt caggactttg 617461 tttttttaat cccagactca ctttcttatg aagaagctgc tttgatcgag ccgttttctg 617521 tcggtatcca tgcggcggcc agaacgaagc tacagcccgg atcaacgatt gcgattatgg 617581 ggatgggccc tgttgggtta atggctgttg ccgcagctaa agcatttggg gcaggcacaa 617641 tcattgtcac cgacttagag ccgctgcggt tagaagctgc gaaaaaaatg ggagcgactc 617701 acattattaa tatacgtgaa caggatgcac ttgaagagat taaaacgatc acgaatgata 617761 gaggcgttga tgttgcttgg gaaacagcag ggaatccagc ggcattgcaa tccgcactgg 617821 cttctgtgcg ccggggcgga aaattggcga ttgtcggttt gccttcacag aacgagattc 617881 cgctcaacgt gccgtttatt gcggataatg agattgatat ttacgggatc ttccgttatg 617941 ccaatacgta tccaaaggga atcgaatttc ttgcttcagg cattgtggac acgaagcatc 618001 tagtaacgga ccaatattcg ctggagcaga cgcaagatgc gatggagcgg gcgcttcaat 618061 ttaagaatga atgtttaaaa gtgatggtgt atccaaatcg ctgagtgaac agggaggatc 618121 ttcgtattct ccctcttgtt tactggaaat gaaaacggat tcttggggtg ggaaatgatg 618181 attggaacag aaaaagtaac ggcattgaag gcgaagcatc agtcaaaatc cagcaccggc 618241 ctgtcctggt ttgaacgaat cggttatgga ttcggcgata tgtcgtataa tattatcttt 618301 cagtttgtaa acgcatactt attattttat tatacagacg tcggcggcat tcagcctgcg 618361 gtaatcgcaa ctttgtttct tgttgtgcgt gtgctggatg ctatttttga cccgatcatg 618421 ggattgattt tagataaaac gaatacaagg tggggaaaag caaggccata tttgctgtgg 618481 gtggcatttc cttttgcgct attcacattc ttatgtttca cgacgcctca tttcggtgag 618541 accggaaata tggtatatgc gtatgtcact tatattctgc ttgggatgtc ctttagtatg 618601 caaacgatcc cggtgaacag cttaacgggg cggatgacga attcggtgga ggaacgaacg 618661 gttctgacca caacccggat gattttggtg tatatcggca ttcttttatc catttcctgt 618721 gcgacaccgc ttgcaactgc tatcggagga gaggatcagg cgtttggatt tcagatgacg 618781 gcgctcatct atgcggctgt cagcatcgtt ttgaatctat ttagtttctt tactgtacgg 618841 gagcggattc agcctaaaaa gagaaaaaaa caagggatca aaaagacgtt atccgtttta 618901 ttcaaaaaca aacccttgct catgttaatt tcatcatttt tggcttttgc gatcgggttt 618961 aatattaagc tcagcacgat ggtgtattat tttacgtata acgtaaacca taaagagttc 619021 gtgtttatgg gcaccgtttt atttttcggg gcagcgctga tcagcaattt gtttattcct 619081 ttcttttctg agaagtgggg cagaaaacaa gtcatgatta tcacggcagc tctatcgctt 619141 atttcttatg ccggcctgca ttttacgccg tattcttcaa ttccactcat tttcatttgg 619201 cttttcgctt cgggattttt cacaacgcct ttaaatacgc ttgcttgggg aatggttgcg 619261 gattgcgtcg attatgcgga atggaaaacc ggaattcgcg cggatggtgt tgtgatttcg 619321 agcatgagct ttattaataa gctgggtgtt gcgttagccg ggtcattttc ggccatttat 619381 ttaggaatcg ccgggtatgt ggcgaataca gaccagacag ttgcgtcgtt gaatgcgatt 619441 aaaaatatga atgctttgat tccgggattt ttcattttgc tttctattat tcttatcgcc 619501 ttctatcctt taacggaaaa aagatataaa cacatcatct ctgagctgga gcaaaggtct 619561 gcgagataaa tagatgtaaa atttttaata ttcaatgttg tatttatggc aaaaagtaat 619621 atactgagac tgtaatctag actttataaa tgagtgtgat aatatgcgta gtcattctgt 619681 agtttgtatt ggggaattgt tgattgattt cttttgtacc gatgttgacg ttgatttaat 619741 ggaagggcgc caattcctga aaagtgccgg cggggcaccg gcgaatgtgt cggcagcgat 619801 tgccaagctg ggcggagacg ccgctttcag cggaaaagta ggaaaggatc cgtttgggta 619861 ttttctgaag cgaacattgg acgctgtaca tgtcgatacc tctatgctgg tgatggatga 619921 gaaagcgcct acaacgcttg cttttgtttc attaaaacaa aatggagagc gtgactttgt 619981 ttttaataga ggcgcggacg ctttgtttac gctggaggac attgaccagg aaaaactaaa 620041 cgaagcgaaa atccttcatt tcggctctgc gacggcactg ttatcggatc cgttttgctc 620101 agcctattta cggttgatgt cgattgcgaa agacaatgga cagtttattt cgtttgaccc 620161 taactaccgt gaagatttat ggaggggaag agtctcagag tttgtaagtg ttgcgaaaaa 620221 agcgatcgct gtaagtgatt ttgtgaaagt cagtgacgag gaacttgaga ttatcagcgg 620281 tgtgaaggat catgaaaagg gagttgcgat ccttcatgag atcggagcca acattgtcgc 620341 tgtgacactt gggaaaagcg gaacgcttct ttccaatgga aaagaccgtg aaatcattcc 620401 aagcattccg gtgacatcaa ttgactcaac aggggcggga gatgcttttg tcggtgcggc 620461 tttatatcaa ttggcaaaca cggatcagat tcaatctgta gatgctgatt ttgtgaaact 620521 gcgtgagatt gtggcgtttg ccaataaggt cggagctctt gtgtgcacta aaattggagc 620581 gattgatgca ctgccgagtt tggatgagat tggagtttct ttgtaaatca ttgaagatgt 620641 ttcttgaaag tctttggact tttgggggca tcttttttta ttgcttacat ttttgttcag 620701 gtaaaaagtt gtatattttt tgtttgaaat gtcatttttt attaaaaaag tgaaactttt 620761 aacgataata aatagtatat gtaacaaggg ttaccgaatt agctttagga ggaacgatat 620821 aatgagtata attggaagat ttaaagatat tatgtctgcg aatatcaatg ctttattgga 620881 caaggctgaa aatccggaga aaatggtaga tcaatattta agaaatatga atagcgattt 620941 ggctaaggtt aaggcagaaa cagcagctgt tatggctgag gagcagagag caaaaagaga 621001 atatcacgaa tgccaggcgg atatggaaaa gatggaaagc tatgcaatga aggcgctgca 621061 agccgggaat gagagcgatg cgagaaaatt tcttgaaaga aaaacatctt tggagtcaaa 621121 gctttctgag ctgcaggcgg cgaatcaaat tgctgcaacc aatgccgcac agatgagaaa 621181 gatgcatgac aaattggtat ctgacattgg agagctggaa gcacgcaaaa atatgatcaa 621241 ggcgaagtgg gcagtagcga aaacgcaaga aagaatgaac aaactgggcg cttctgtttc 621301 aagtacaagc caatcaatgt ctgcattcgg ccgaatggag gacaaagtaa ataaggcact 621361 tgatcaggcc aatgcaatgg ctgaactgaa cagcgctccg caggatgata tggctgatct 621421 gtctgcaaag tatgacactg gcggttcaag ccaggttgat gatgaacttg cggcgttaaa 621481 agcgaaaatg atgctcgata agtaatacat aggaggccgc agctttcggc tgcggcgtca 621541 ttttatcata aaatgtgaga gggaacggta atgataatat cttataagtg tccgaactgc 621601 ggcagtgata tggcatttga cagtgaaacc ggctcgttat cctgcagcag ctgcggaaga 621661 caggacaata ttgaaagcct tccgaaagaa aacattgcgg cacggttttc tgatgatgaa 621721 gcaaaagaat atcaatgtaa aaactgcggt gccgttttga tcacggaagc tgaaacgaca 621781 gcaacgacgt gcagcttctg cggaggtgct gcaatacttg ccgatcgttt atcaggacat 621841 ttggcgccgg cgaaggtcat tccatttaca atcagcaagc aagaagcgga gcaggcattt 621901 cgaaagtggt gcaaaaaagg ccttctgaca ccaagaggtt tcatgtctgc tgatcgtatc 621961 aaaagcatca ccggcatgta tattccattt tggatgtttg atttaaatag tgaagtacag 622021 gtgagagcaa actgtaccag agtccatcaa tatgaagaag gggattatat ttgcacggaa 622081 acagagcact ttgaagcgtt tcgtgatatc aatctcgatt atttgaaaat ccctgtcgat 622141 gcctctgaaa aaatgaaaga cgaattaatg gacaaattgg agccttattc atacgaagag 622201 ctgaaggact ttcaaacggc atatttggcc ggttatattg cggaaaagta caattatacc 622261 gatgaggagc tttttccgag ggcaaaagag aaaatcagca gttatataga ttcatacatc 622321 cattctactt tttccggata tacgtcagtc aatgtgaggg acaaacatat tcacacgaaa 622381 aacgtgaaca gcttttacgt tttgcttcct gtttggatgg tcagttacga ttatgaaaga 622441 gcggagcata tctttgcgat gaacgggcaa acaggaaagg tcgttggaaa gccgccgatc 622501 agtcgaggaa aagtggctgc atggtttagc ggaatagcag gcgggacatt tcttgcgttg 622561 aagctcgtct cattgatgat gggaggcgga ttttgatgcg tggatttttt gggaaagcga 622621 tctttgttgt gctggctgtt ttcatcatga tgcctttact gggtatcgaa gcggtaagag 622681 cctctgaatt gcagcagcat gtgtacgatc gcgctcatct attgtcaaaa gcggagatcg 622741 gaaaacttga atctctctcg gcaaagctgg gtgcaaagag ggacactgat ttcatcatta 622801 ttacgaccaa aagcacaaac ggtgaagata ttgcagacta taccggcgat ttttatgatc 622861 gttacggaaa aggcagtaca gccattctga cgattgatat gacaaacaga gaagtgttta 622921 tcgcaggctt taaaaaagcc gaacagtatt tggacaacag caggctcaat agcatcagaa 622981 atacgatttc atctgattta tccaatgaaa attattttga agcttttgag acatatattc 623041 agctttccta taaagatatg ggcataaaac cgggagtaaa ccctgacaac atattcttta 623101 catggtggtt tcagctgatt gctgccatcg cagtcggggg aattgcggtt tcaatcatgc 623161 tttatcatgc aggcggcaaa gtaacggtta atggaagtac atatatggat cagcgtacgt 623221 ctgatgtgat tgatcaatac gacacttata ttagaacgac tgtaacaaga gaaagaaaac 623281 catcagataa agacagcggc agcgatggcg gtgttacgaa aggcggcacg tcatacagtg 623341 ggagccgggg cagtttttaa atgtaagaaa tagagaaagg gagaggcgta atgtcgtttt 623401 tcagaaatca attagcgaat gtagtagagt gggaagaatt tagagatgat atgatttttt 623461 ataaatggaa caatcgtgaa atcaaaaaag ggagccgttt aatcattcgt cccggacagg 623521 atgctgtctt tttgaacaat gggcgggttg aaggagtctt tcaagatgat ggcgattatg 623581 atattgaatc agaaattatt ccattccttt caacgttaaa gggctttaag tttggcttta 623641 acagcggcat gcgagctgag gtgctgtttg tcaatacgaa ggaatttacc gtaagatggg 623701 gaacaaaaca ggcgataaat attccggcag cgggaatgcc aggcgggatg cccattcgcg 623761 caaacggcac atttaatttc aaggtgcagg actatatcag cctgattgat aaaatcgctg 623821 gcgtgaaaga tcaatatttt gtagaggata ttaaaacccg tatcatttct attctggatc 623881 agcttctcat gaagtggatc acaagagaag ggaaagatat gtttaatctt caagcaaacg 623941 cttttgatat tgccaaggga attcaagagg acttagatat gcaattaata agcgacggga 624001 tgacggtcac tggttttcaa atcatgagct ttaattatcc tcaagaggtt caagatatga 624061 ttacaaagaa cgcttcctac ggtatggttg gggatgtgaa cagataccag caaatatcaa 624121 tgacggatgg aatggcatcc ggaaagatga gcggaagcgg agcggcttcg gatatggctg 624181 gaatgatgat gggaatgaat atggccaatc agatgatgaa ccaaatgaat cagaatcagc 624241 aggcacagtc atcaggccca cagtcaactg gcagcggaag caaaccgaat ttctgtccaa 624301 actgcggaac aaaaacgggc gaagccaatt tttgtccgaa ttgcggccag aagcttgtat 624361 aagaatcata cagtgaaaag tccggagtga tcagcactcg ggactttttt atttaggaga 624421 ataagcatta cctattgctt gctcctgaac aggccatttt cgagcccccg cttggataat 624481 tcccagcagc aattgacgac gttcctttat tgaattgacg gcaatttgaa atgtttgctt 624541 tgataaagcc ggtatgcctg attgttgaag ctttgagatg tctggttctg gcggcgcttg 624601 ttctgcagga tggatatagg cagtatgaac ggtatccaga tagtttttga tacttgagcg 624661 cgcttctttg atatgaagct gattcggctg atattgttca ggaattccgt atttgaaaat 624721 ggttagagcc tcatccaata cagcaacagc tataatggat gattcctgat gctgcgtgct 624781 gtggtaaaaa tgaaggatgg ggaaggcgtt atgctgagcg gtcagctttc ccagttctga 624841 tgaggcagcg acaagaagaa aatcaatgtc gtgaaaatct ttgccattcc atgcattatg 624901 gacgatttca gttccgtcat gccctagact taatacactt tgggcaaagg agcgtttttg 624961 attaaccgca ctcaagacgg aaatcaaata cgtgacagaa aatgtgatgg taagcagtcc 625021 ttgagctgtt tcaataatcg tgacaagctt ccataggcct ccgttcggag cgaggtcgcc 625081 atttcctaat gtaaacatga catagccgga aaaataaatt cggtctgacc aggaagccgg 625141 ttcttttgat tgagtttcca taagtgagtg agggtcactc gagtaaatca aaacccaccc 625201 gctccaaaat agactgatcc atatcactaa cgtcaggcat aacagcagag gaccagccat 625261 acttagaacc tttgcgtggt caccgctgat tttgcggcag cccttccaca gccaggcaga 625321 caggcatctt gtgatcgggc cggcaccgct ctctaaccat aacgtggtcc ataaaaaatc 625381 aatcatcccc gctgtcaata ataaaaggcc tgcaatgata taaccctcat tcattttggt 625441 tgcctccctt aagtcagcct tcttttattt tcttctctat ttccttttat cctgagtctg 625501 aaacaattga acgaatgttt gattttacag agaaaaatag gtgggagtta cccaacactt 625561 actcattttt caatatgaac agaaaatcac aagatttttg acttgattca cacattttca 625621 tgaagaaaaa cgttcatttt ccccttgaat tggtgatttt ccttttatag agtaaaaaat 625681 tttcagaaat ttatattgac tgaaagcgtt tttataatta tgataatatc agatataaca 625741 aaaatgtcac tataacatca ctacaattga actattaagt gactaataaa taccaaatga 625801 acgaggttat gcacaaagaa atgaccattg ttcttttaac gagaaatgaa atcgcttcca 625861 tagggattga catgctaaga agaagggaag gttatgaggt tattggataa aaacatgaac 625921 aactattttc tgaagcctgc ttacgaaatg tgaggaaggc agcagccctg gaataagttt 625981 ttgacatacg cattttgaaa aagactgggg gaaacagtat gaataaacaa ggaaatcaaa 626041 tgtcattttt acgtacaatt attttagtct ccactttcgg cgggcttctt tttggctatg 626101 ataccggtgt gctcaatgga gctttgccgt atatgggaga gccggatcag cttaatctca 626161 atgccttcac agaaggcctt gtcaccagtt cacttctttt tggagcggca ctgggtgctg 626221 tgtttggcgg caggatgtct gattttaacg gccgccgcaa aaatattttg ttcctcgctg 626281 ttatattttt tatttcaacg attgggtgta cgtttgcacc aaatgttacg gtcatgatta 626341 tttcccgttt tgtgctcggt attgcggttg ggggtgcatc cgtaacggtg cctgcctatt 626401 tagcagagat gtctcctgtg gaaagcaggg gacggatggt gacgcagaac gaattgatga 626461 ttgtatcagg acagcttttg gcctttgttt ttaatgcgat ccttggaaca acaatgggag 626521 acaactccca tgtgtggagg tttatgctgg tcattgcgtc acttccagcc ttgttcctgt 626581 ttttcggcat gatcagaatg cccgagagtc cccgttggct tgtttctaaa ggaagaaaag 626641 aagatgcttt gcgtgtattg aaaaaaatca gggacgaaaa acgggcagca gctgagctgc 626701 aagaaattga attcgctttc aaaaaagaag accagcttga aaaagcgaca tttaaagatc 626761 tttcagtccc atgggtgcgc cgtattgtgt ttattggatt agggattgcg attgtacagc 626821 aaattacagg tgtgaattcg attatgtatt atgggactga aattctaaga aattccggtt 626881 tccaaacgga agccgcttta atcggaaata ttgcgaatgg cgtgatttcg gtattggcaa 626941 cattcgtcgg aatctggctg ctgggaagag tggggcgccg gccgatgctg atgacaggct 627001 tgatcggtac gacaacagca ttattgctaa tcgggatatt ctcacttgta cttgaaggat 627061 caccggcact tccgtatgta gtcctgtcat taacggtcac atttcttgct tttcagcagg 627121 gcgccatttc accagtgact tggctgatgc tatctgaaat tttcccgctt cgccttcgcg 627181 gactgggaat gggtgttacg gtattctgtc tgtggatggt gaattttgca gtcagtttca 627241 cgtttccgat attgctggca gctatcgggc tgtccacaac gttctttatc ttcgttggat 627301 taggaatttg ctctgtcttg tttgtgaaga ggtttttgcc ggaaacgaaa gggctttcgc 627361 ttgagcagct ggaggaaaac ttccgcgctt atgatcacag cggggcaaag aaggattctg 627421 gggctgaagt gattggataa tttaaaaaag aatccgcacc cgagtgcgga ttctttttgg 627481 tttcaaatta gttaggtcta acaaggattt tgacttggct tttctcttta ataagagccc 627541 cgaagccttc ctcgatcaaa tcatctagta cgattttttt cgttacgagt ttgtcggctg 627601 agaaatagcc ttctttcatt aatgacaata cagccgggaa gatgtcgcgg tatccgataa 627661 ttccttttac tgtacgttct ttgattacga tatcgttcgg atggatttca gcaccttttt 627721 cccaaatgct gacgatgacg gtttcaccgg caattgtagt ggactggatg gcttgtcgta 627781 acaccactgg gacaccagtg acttcgaatg ctacgtcaac accgcctcct gtacgttctg 627841 caatctcagc gactacatcg tctgttttag acggatcaac gatgatcgcg ccaagctcct 627901 cagctttttg ctggcgttca ggagaaagct caacagcgta aatatcagtt gcaccggcag 627961 ccttcagcgc ttcaatgaca agaagtccga tcgggccgca gccgaataca gccgctttgt 628021 cgcctgcttt gagtttgctt gagcggacag cgtatagagc aactgcagaa ggttcaacga 628081 gcgcgccttg ttcatatgat aattcatcag gaagtttgaa caaaagctct tcatccacag 628141 agacgtattc agagaaaccg ccgcctccgc cggctaagcc gaggaatccc atttgttcat 628201 caaggttgta ggcgccttgg tggccgtgtg tagcaaaaat cggctcgact acaacgcggt 628261 ctccaacttt ataattttca acgccttctc cgacttcgac aacttcaccg gagaattcat 628321 gccccattgt gacaggtgcc gtttcatttg ttaatgggtg cggtttgtca accggaataa 628381 agatcgggcc gcccagatat tcgtgtaaat cacttccgca gatgccgcac catttgactt 628441 tgatctttac ttttcccggc tccgtttttg gctcttcgat atgttcaata cggatatcct 628501 tttggttatg ccatcttgct gccttcatgg attaccactc ctataacttt tgatgtgagt 628561 aattccgcac cggtcaatat gaactgttca caaaatcgcc atttttaaaa ccaaaaaaga 628621 aatgaaattt ttatataata taatctacgt ttttttgaaa aaaagaaact ttaaagaaaa 628681 aagggtctcg cacactcttt tttctttata tgagagtatc aatcgtttac atagctatga 628741 atttggtttg aacaatacgg taatggttcg ttcatattga atgcgacaac tactctatca 628801 ataattataa ctctaatact gctattataa taggataatc ttccatggtt tattttagca 628861 gaggtaactt ttttgacttt gtaacattac tgtaaggata ttgaaataaa aaatagctgg 628921 ttgatcgtgt ataatcttcc tagatgttaa caaacagggg gacgaaatgt tgaagaaagt 628981 cattttagcc gcttttatct tagtaggaag tactttggga gcttttagtt tttcatcaga 629041 tgccagtgcg aaacatgtga acggaaatat tacttggtat aatggagtcg ggaaaaaagg 629101 ctcttcaggt aagaaacttg gacattggga ttgtgcgacc aaaatcggat ttgatgttcc 629161 tagaaacggg acaaaaatca gagcttatgc aaaagcgaag cctaaaaagg tgattacggt 629221 ttataaaaat gatgttggca gaatgcctaa tgcagtgctg gatgttagcc ctaaagcgtt 629281 taaagcgctt ggatacccat taagcaaagg taaagtagcg gggcattaca gctattaatg 629341 tacatatata atctggaaag caagaagtca cattcttgct ttttctattg gtggagataa 629401 aagatgaaaa aaagaatcat attattatta gcagtgataa tagcggcagc tgccgcgggg 629461 gttgcgtttt atgttgcaaa ggataaaggc catgagaagg ctgctgatgt ttcagtcaat 629521 accgaaagcg gtgatgagct gctggtttca attacagata cggatctgct gacaaagtat 629581 tatgaaaatg acaaggtgat ccatgaggag aagctgacca gctatccggc atttgccttg 629641 gatcaaaaac agcaggtgct ctattatacg ggcaataatg aacagaatga aatgaggctt 629701 tttaaattgg atctgaagtc tcataaaaaa acgatgcttt ataaaggcgc ggagagtgcg 629761 gacagtttat ttttatcaaa ggaccgttca accatctatt tccgcttagg aaaagcggac 629821 gaaagcaatt ttcgaatcgc cgcttttgat ctgaagacga aaaagtataa aaatctttat 629881 cctgccgcta atgatcagga tgacaccgtc agcagcttct tttataacca aaaaaacgat 629941 tcatttgcat tgcttcatta ttctgtagaa gaagactaca agaaaacaga tgaagcaaac 630001 gaaaagggca tcgaccctga accgacaacg attcattttg cggaaggccg ccaaaataaa 630061 tttaatgagc tgaaaagcct gaaccaattt atcagcgata ttgctgtttc tgatgatgat 630121 aaacgtattt tattcacatc atatacgcaa aaaggaacgg agcaaaccgc ttctattcaa 630181 atgctcaatg cggatacgaa aaaatatgaa agcatcatct caaatcaaaa atcatttaag 630241 ctgttaattg acgcacagcc tcagttttct aaggatggga agaacattta ttttcttgcc 630301 gaagccaagg gggctaaaaa gctgaaggac gaaacagggc gtgaagctaa ggtgcggacg 630361 atttattcct atagccttga gaataagacc ttcaaaaaag tatgggaaaa tccgaacggc 630421 atcatcaaca gcttttttgt gattaactaa taaaaaccac tcggcatgag ctgagtggct 630481 tttttaatgg atgaggtgca gggctaatga tccgagccat ttaaagatat gaatcagagg 630541 taccgacaaa aacagaagtt caacatatga gttcattgca acattcagct ttttgaacgc 630601 agctcttttt ttcaagtctt tttgctgctg gtttgagatc acgttatcac tcctcttata 630661 tccatattat accattaaaa cagacaaaaa agccctaaac gtttacagtt ttgggcttct 630721 ttcttcgtat ttggcctctt gcaatgagag gcttttattc tgaaatatag aattttgtct 630781 ccgttcgggg tttgtttgct tgcgggagac tgcatttgtt atagggaaga actagcttgt 630841 tttcgtttgg ctgttgtttt ggagattcac taatgaacgg atgccgtcga ccattttact 630901 tccgcacaaa gggcacaatg gcgtatcact gctggcgaag ttttttcggg tccagccatt 630961 acagtcttct tttgtgcatt cccaagtact cacatcttcc tttggcagcg gttcttgatt 631021 tcgtttgtta tagtaagaca taaagtcact tcttccctca tgtattttac tgcacatttc 631081 ctattgtctc atacttttcc ctaatctcct aattcctttt tctttatgac tttccaataa 631141 ccccatctaa aaaggagagg agtgtgctgt taaaagcatc tggctcttct aaaaacgggc 631201 aatggctgct tttaggaaag gtaacgagtg tcgcgtttgg aatattgctg cgcaagtgtt 631261 ccccagctgc tgtagagaaa aatttcttgt cttccccgaa gcacagcaat gccggcacat 631321 tgatgttttg gagggtgccc cggtaatcag cggccgtttg gttaaataaa atcgtgctag 631381 aaatggcagc cggctgtttg aggatttctg ccagcatcca ttctgtttcg gtctcggcag 631441 gcggttctgc gaacatattc tggatgaagc tttcgtagaa aggcagcggg tcagtttgaa 631501 tggcgtgcat cgctgttttt aagccgtcaa aatcaaatgg accatgttcc cagccctccc 631561 attgatagtc cgaagcggat tgatcgatga tcacagcggc ttgaatgtta tcattcccaa 631621 actgattgag ataatcccat acgacaaaag cacccattga ccagccggca agaacgacat 631681 gatcaagctc cattgcattt agaaattccc ttatgtcacg ggcatattgg gaaatggtgt 631741 ggccgtgaag cactttgtca gattcgccgt gtcctctaag atcaagacga atacattgat 631801 aattggcaga aagcaccgaa aattgtttgt ggaaaaattg tccgctcatc agcaccccat 631861 gtataaacag gatcggcgtc ccgctcccgt gtgtttcata gtaaaggcgt gtctgatctt 631921 ctaatatgat gtatggcatg tttctcctcc tttagtttcc atcatgagta tggctggctg 631981 ctgttgagct gatgatggca gctgtcgcgg ctgcctgctg cgcttgaatg actgtttcga 632041 tagcggtgta tagtcctgat tccatcagca gatttttctc catatgctca ctgagataga 632101 ggctgacagc aattttaaag ttcatttcct tttgccattt aaaagctttt tcctggttta 632161 attcgtcagt gatgcacaaa acggttttga tatctggctc ttccagaaat gtgaggagag 632221 caaggtctgg ataatgataa tcctttgttt ttttgacaga ttcagtgatc gattgatata 632281 tctgtttgca agcggaaaca agcatttcgg gctctttttc actttgcaag gccagaatat 632341 ggctgacctg atgtaagtac tgtccttttt taaagccgtt ggctgccagc agttgatagc 632401 atgtttccgc cttctgtagc gcctgcaaac cttttccgtt ttctccaagc agtacggcaa 632461 gcggaacatt ctgagttgaa gtgaggaaat aatgattttt cttcatctgc tgataaacag 632521 ctagccccat gttcatctgt tctttttggt ttgtcgtttc agatttgccg gtgagcaaga 632581 tcagagcgga aaggtatgtg aacatatccc gcttataccc tagcttcacc atttcattgt 632641 atacatcgat gaaagtctga aatgtttgtt ttgcctcatg ctgaaaatga atgtccagaa 632701 tagatgcaac agtaaagcgg tggtgtgaat tgagtgttga gaagctgccg atgtttgatt 632761 tgatatagct gctcaaatca taaaagcgct gaaaatcaaa ctctctttta ttcacaatat 632821 atgcagaaga aatgagcatt aatatctgat cgtgtgaaac tttccatttt aattttgttt 632881 ttaattcagc ataaatggaa atgtaatgct ttgttttttc atgtagatcg tgtgtgagca 632941 taaaaagcag ctccttttgt tgtttttacg taatacgata aatagggcca aaggtttcat 633001 aaagaaaaaa cttgcctgct agaggcaagt ttgtcgggtt atttatgggg atcagttata 633061 tccatcggtc tcatcatgtc atagtcttca tgctctagaa tatggcaatg ccatacgtat 633121 cgtccgctgt acggaccgaa tgtcgccgcg attctcagga cttcacctgc atgcgcttga 633181 atggtgtctt tccagccctt ttcacttggc ggcggcggga cagccggacc ggtataggac 633241 aattccccgc tttcttgata acgggcgata tcaaacggcc gccggtctaa tacacggaag 633301 gagactagat gcaggtggat cggatgtgtt ccgcgtgtcg ggttgataat ggaccatatt 633361 tcagttgtgc cgacttttgg tgtttctgtg acgggatcgt gccagcgttt gttattaagc 633421 agaaggacgg gtctgccgta ttcgtcctgg gtgcctgcca gttttaacgt tctgatgttt 633481 tgtattcttt catgctgtac cgaagggtat gaggcgaggt acttcggctt tctgctttcg 633541 tctttttgtg ccaatggttt tgtgactctg aattgcatga tattcgcatc tgtttcagga 633601 ttgacgtcac cgccgcagcc cgcgctgttt gccaaaatga tcgattctcc ttcatatgct 633661 gtgaagtcaa tgatgatatc gtaacgttca gcaggcgcaa ggctgaaaga attcagttta 633721 acagatcgcg gcaggagccc tccatctgaa ccaatctgaa taaaatctcc gccattatcg 633781 agtgacaggt tataggttct tgtattggag gcgttgatga cacggaatcg gtatttcctt 633841 ggctcgactt ccaagtatgg ccataccttc ccgttgacga gtatggtttc tccgcaaaaa 633901 gccggaacga ttgaaggatt aggcagtgac ggagaagggt tttccggtgc gctcggataa 633961 aacaaagaac catcctcatt gatcgtgcgg tctgtgataa gaagcggcac atcgtattcg 634021 tctgaaggca gttttaagcg tttttccttt gggtcatgaa tgatatatgc accgacaagt 634081 ccggcataga catttagcct ggtgagcgcc atggcgtgat cgtgatacca caatatagcc 634141 ccgcgctgct ggtttggata atgataaacc tctcttttga aataaggtcc tgtttgttca 634201 aagtctttgg aaaaccaagc ctccggatac ccgtcactat catctggcgt gacgccgccg 634261 tgtaaatgaa caacagtctt tacctcgggc tcttcatgct ggctgtcact gtgatgaatg 634321 gtgtgatcaa tcggaaggaa atgcgtggaa ggaaggttat tcatccattt tacatatacg 634381 ttttcatttc ttttaacctc aatggtcggt cccggaaata agccgttgta gccccacagg 634441 cgggttggag ggagatcgcg atggagctga tgagtgcatt cctccatggt gacttcgtag 634501 tatgtttttt cttttgattg ctgtactggc tttagtgtat ctgggattgg gagagcatcc 634561 acaaattttt caagtgtcat tttcatctgt ccttatctaa attttccaaa ttggtactat 634621 agttaatgac aataaggacg tgatggttac aaaaaatctt cgtgctgcag cccgcccgaa 634681 gaagaaaata acaaaatcct aaacggcagg ccgtttagga tttgatcagc attaaggcag 634741 gatatcgggt tgctgctgtg tgactgggtt ggcagccgct ttctcgctca ccttgcgttt 634801 tctgaacaca aggtaagaaa tcagaacgat tcccgtgatg acgcctgtca gcagcagctc 634861 gtctctcatg gaatcaataa acgccatgga cactaaaatt ccgcaaatgg cgatgatggt 634921 caagtaggtt aggaaaggga agagccacat tttgatcttc aatgcttctg ggtttgtttt 634981 ttcgagtttt ttccgcattt tcagctggga aacggcgatg acaagataga cgagtaaagc 635041 gattgcgcct gatgagttga ctaagaataa aaagacggta tccggtgaaa aatagttcat 635101 tacgaccgcg atataagaga aaaatgtccc ggccacaatg gcttgtacgg gaacgccttt 635161 tttgctcaat ttcataaaac ggcgcggcgc ttcatttctt tctgcaagtg aatacagcat 635221 tctggatgtg gtatacaaac ctgaattcag gcaagagagt acggctgtga ggacgataaa 635281 gttcataatc tgtgcggctg cgggcactcc tatatgctca agtacagcga cgaaagggct 635341 ttctaaaata tttgctgaat tccatggcaa cagcgccacg acaatggcga ttgagcccac 635401 gtaaaagacg atgatgcgcc atacaacgga tctggtggct tttgtcacag attcgatcgg 635461 gttggatgtt tcccctgctg caatggcaac gatttcagtt cccataaaag agaagatgac 635521 aacgacaatg ccgagcaata cggagctgat gccctccggg aaaaatccgc ctttgcctgt 635581 aagattcgaa aaaccgactg gctcactgcc cggtgcaaag ccaaaaataa aggcaaaacc 635641 aacgattaga aaagcaatga tagtcacaac tttaatgagg gagaaccaat attcaaactc 635701 accgaaagac ttaacggagt agacgtttgt cagggtgagc acaatggtca agatcaaact 635761 tgtcagccac agcggaatat catggaacca gtattgaata atgccagcac cggcaatggc 635821 ttcgatcgct atgacgatca cccagaaaaa ccagtacagc cagccgattg taaatcctgc 635881 ccacggtccg atggcgtcgt gagcgtattg agaaaacgat ccgctcgtcg ggtttacggc 635941 agacatctca ccgagcattc tcataataaa aatcaccaat aatccggcta acgcgtaaga 636001 aacaacggca cccggaccgg tcgagtgaat cactgaaccg ctgcctacaa ataggccggc 636061 tccgattaca ccggcaatcg aaatcattgt catatggcgg gtctttaatt ccttttttaa 636121 tcctgattga gactggttca taagttacct ccttttaaaa tgcaatcatt actgaatatt 636181 atgataattg aaactctatc ataaatatac agtttgtcga aaattcgtgt aagaaaatat 636241 accagcttat ttcaaatttg tagtgttttg tttgcgcttt cagcgaatgt gtggaaaaaa 636301 tgtttcgttt tttattcgct gtgtgatttt gcgtaatatt tacaattcga tagaatgcga 636361 gaagcactgg tgtccttggg tttgatggga tttttggcgg agcaaataaa ttggatgaga 636421 gaaaaagtgt tccttcgtca ctatttttct gtggcgggtg aatcatgttt ctgtagaccc 636481 actgcggatc agctttgtaa gataataata ggaaaatgtg agcgagagga ggttttgtat 636541 ggagagatat gatgaactga aaaagggaga atccggagcg ctggtcagca ttgccgcgta 636601 tctagttctt tccgcaatta aactgatcat cggttatctt tttcactcgg aagcacttac 636661 ggcagacggg ttaaataaca caactgacat tattgcttct gttgctgtgc tgattggcct 636721 gcgcatctct caaaagcctc ctgacgaaga tcatccatac ggccactttc gagcggaaac 636781 gattgcatcg cttatcgcat cgtttattat gatggttgtc ggactgcaag tgctgttcag 636841 cgccggagaa tctatttttt ctgctaaaca agagacgcca gatatgattg cggcttggac 636901 ggcagcgggc ggggcagtcc tgatgctgat cgtttaccgg tacaataaaa ggctggccaa 636961 aaaggtgaag agccaggcgc tccttgctgc ggctgctgat aataaatcag acgcattcgt 637021 cagtatcggc acatttatcg gcattgtggc tgctcaattc catcttgctt ggattgatac 637081 ggtcactgcg tttgtgatcg gtctgcttat ttgcaagacc gcatgggata tctttaaaga 637141 gtcatctcac tctttgacag atggattcga cataaaggac atttccgctt ataaacagac 637201 aatcgaaaaa atctccggtg tgagccgttt aaaagacata aaagcaagat acttgggcag 637261 tacggttcat gttgatgtgg tggttgaggt atcggcagat ttaaatatta cggaaagcca 637321 cgatatagcc aatgaaattg agcggagaat gaaggaggag catgcgattg attattcgca 637381 tgttcatatg gagcctttag aacaaaaata atggagcttc ctgtcacagg aagcttcagc 637441 gtgtcgacaa accctcgcat tcgttgtcag gtctgcgctt cggtgctcac gaattagaac 637501 attcgctccg ctcctatgct cgtccttcct agacttcaag ggttttcaat cacgctgaaa 637561 agatgacaaa accctaaaat gaaagccatt ttaggatttt gtcaacaatc tggagcttcc 637621 tgccacagga agcttttttg tgtgttttgg ccagctttat tggtaacaat ttgctagaat 637681 cgttttttta tacagattgc tttttgtggt aaagttaggt tacattatga tgaattttgt 637741 agatgactag gaggaaaata atggcatatc aagaagacct gcatcctttg ctggggaaag 637801 cagttgaaca tattaataga gtaatggttg gaaaacgaga catcgccata ctcagcttag 637861 cagcccttct tgccaaaggg catgtgctgc ttgaggatgt acccggagtc ggaaaaacga 637921 tgatggtccg cgcgctggca aagtcaatcg gcgccgattt caaaagaatc caattcactc 637981 cggatttgct gccatctgat gtaacagggg tatctatcta taatgcgaaa acgatggaat 638041 ttgaatatcg tcccggccca attatgggaa atatcgtgct ggcagatgaa atcaaccgta 638101 cctctccgaa gacacagtcg gctttgctcg aagcgatgga agaggggagc gtcacggtag 638161 atggccatac gatgcagctt gccgatccgt tttttgtgat ggcaacgcaa aacccggtcg 638221 aatatgaagg gacctatcct ttgccggaag ctcagcttga ccgtttttta ttcaaacttc 638281 ggatgggtta tccgtccttt aatgaagagc ttgacgtctt atctcttcag gaaaaaagcc 638341 atccgattga gacgcttgag ccggttattg caaaagaaga cttcatcttt ttacagaggg 638401 aagtgcaaaa tgtccgtgct gatgacagca ttaaggaata tatcgttgaa attgtgcaga 638461 aaacgagaca gcatccttct gttcaattag gcgtcagtcc gcgcggctca atcgccctca 638521 tgaaagcggc acaggcatac gcgctgctgc atcatcgcga ctatgtcata ccggatgata 638581 ttcaatattt agctcctttc acgctgccgc accggatgat gcttcatcct gaggcaaaat 638641 ttgaagggat tcaggcagaa gcgatcgtaa gggagatcat gtcagctgtg aaggtgccgg 638701 ttcaaaggtc ggcggtccgc tgatgaataa gaaatggcaa tggctcgtat atggttggaa 638761 gctgattata ttaactttat tgacggctgc tgttttttct tatgcgatgt ttcagggcgg 638821 ctttgtcagc tggtttttgt tttacgcgtt tctccctttt gtcttgtatg ccgggctgtt 638881 ggccttgtat ccgctccgtt cttttcaggc ttcaaggcaa atggataaaa cacaattgca 638941 tgcgggggac aggctgggcg taacggttac gctgagaaga aagctgccat ttccgctgat 639001 gtatatggtg attgaagatt gcctgccaga aggtatcgag tcattaaatc gagacggagc 639061 cgcggccaaa cggctcgttt ttccttggtt taaacggagc atgacgatgt cgtatgaatt 639121 agctcgggta ccgcgcggag agcatcactt tcattctgtc agggtgcgaa ccggggatgt 639181 tcttggcttg attgaaaaaa cagcattttt tgagctggat gataccttgt ttgtttatcc 639241 attctatcag cgtttttcct atcaggtgaa tgagaggcat caggaagacg gtgtaagcgg 639301 ttcttctcct attcatcagc accattcctc agtcgcagca agtgtgcgga attatcagcc 639361 gggagaccgg tttgctgcgt tagattggaa gacatctgca cggcggagcc agctgatgac 639421 gaaggaattt gagccttctc gcagcaaaaa tctgtttctg ctgatggacc gtttttcctc 639481 agacgcattc gaagaggtcg tttcagtgac agcttcgatt cttcattctg ttttaaaaaa 639541 cggcgcgggt gctggtctgg cttccatcgg gaaggaaaaa aacattttcc ctattcagga 639601 aggggatcag cattttaagc acatgcttcg gcatttagcc atcgctcatt gtgatgcggc 639661 agacccgata agccgatatg cacgggaaga gctgggaaag ccatctgttc gccaagctga 639721 tcaagttgtt gtcacgggac agttaacgga agatatgctg cacctcgcag aaataggagg 639781 cggccgggtt acggtgatac tggcaaaaga gaaagatgct gagctctctc aagctgaaaa 639841 tgtcatgatt gaacgcatga tgaaacgcca aatcagagtt cggatcatga ggggcgggcg 639901 agtttcgcgt gttgtttaga aagagaggtg actggttcac atgccgcacg atgatcacaa 639961 gggaagccgt ttgagcttgc tgttatttta ttttctggct tttttattgc tgtgggagtg 640021 gcttaggccg cttgacagtt ttactgaaac gaaacataca ggctttttta gtgtctttat 640081 cggcttgacg tttctgctga cttttttcag gatgaggtgg tttgtcaccg ttcctttttg 640141 tgtcatattt acattgatct cgatacacat cctgttttat caaggatcta tattcgactt 640201 gagctgggtc agctcttttt tgcaggatgt ctatctgaat atcacgctga ttcaatcagg 640261 gcaatggaat gacatgattc cttcatttcg gaccctgctg ttttttgtgc tgctgtggct 640321 gctggtctat ctcctgcatt attgggtgat ttaccagaga agaattttgt ttttcttttt 640381 gatgacagta gcgtatatta cgattcttga tacctttacg ccatatgatg ccacttttgc 640441 cgtaatccgt atcgtgctga tcggcttctt tatgctgggc cttttatact tggaacgcat 640501 taagctgatg gaaagaatca cactgccaaa aacatctgtc ctgaaatggt ttcttccttt 640561 atctgtattg gttttggctg caacgggatt cggactcgcc gctccaaaat cagagccggc 640621 ttggcctgat ccggtgcctt ttcttaaaaa aatcactcat caagaccgcg tgtctgcagg 640681 ggaaagcaaa atcggatacg ggaatcatga tgaatcactc ggcggcccgt tccagcagga 640741 tgctacacct gtttttacat ggcagggaaa agagcgtacg tatttccgtg tggaaacgaa 640801 ggacacgtat accggaaaag gctggattga aacagacaca ggcatgtcgt atcagcttag 640861 caatggaaaa gttgaaaatc tgtggtttga ccataaggtt gcgacagagc gccgcaccgt 640921 ccgtgtaaaa gtcgataagc actacgggta taaccatctg atgtatccga ttggtgcgga 640981 aaccattcag ccaaagcagg ctgtctcact tgaaatgaac ggcaacacgg agcaaatttc 641041 tccgatcagt gaacaagccg gtgaaatcag aaatatgggg aattatacag taacgtacaa 641101 ttccccggtc tataagctgg atgaactgag aaaggtaaaa gtgagaaaaa acagtgagga 641161 gtacacattc agcgatcgct acatgcagct tccagattca ctgccagagc gggtgagaac 641221 ccttgcgatc aaactgactc aggatcacga caatatgttt gataaggtga aagcggttga 641281 ggactattta gggtcaaatg cgttcacata tgaaacagaa aacgtgacca ttccgaagaa 641341 tgatgaagat tatgtcgatc aatttctctt tgaaacgaaa atgggttatt gtgataactt 641401 ttcttccgcc atggtggtgc tcttgcgctc ggccggcatt ccggcccgct gggtaaaggg 641461 ttatacgtcc ggcgaataca aagaagcagg gaacaaaaat ggcagcattt acgaagtgac 641521 aaataacaat gcccattcct gggtagaggt gtatttcccg gaacagggct gggttacatt 641581 tgagccgact aaagggttta caaatccggc tcaatttaca tcttctgaca caaaagactc 641641 tggcagcgat agcagcagct cgccgaagaa agcaaaagag aaacagaaag aagagaaaaa 641701 acagccgcaa aaagaggaaa aacaaaagga aaagcgggag ccagctgttt ctaaaaagcc 641761 gtccgcttcg catactaatg ccggtgcggg cttgtatgca gcgcttgcgg ttcttgcagt 641821 cctcctggtg gcagctgtat tgctgtatgt tttccgctcg ttatggattc ctgttttcgc 641881 cgtgaggaaa ttgaagcggc gcagtgatca gcacgcgttt tttgaggcat atggcgcgct 641941 gctgaaacaa ctgaagagaa aaggactgcc gaaacgagac agtgaaacgc tgcgtgatta 642001 tgcaaaacga attgatgaaa aatacgacat agaagacatg tcaaagctga cattaagcta 642061 tgaaagggcg ctttacagaa atgaagattc ttcggcgcta tggaatgatt cgagagagtt 642121 atgggaaaat ttaattaaaa gaagatggtc ttgaccgctt atcgacgtgt tgttagaatt 642181 agtgaatatt atcggagtct gggagcgagt tggcctgact ccggcaaacg gccttgccaa 642241 agagggcgga gcgagcttca tatctgtcct cgtttttttc tgtgtcaaaa aacttagagg 642301 agattaggtg acaaccatga caaagttagt gaatgaaatg attcttgtcc ttgatttcgg 642361 cagtcagtat aaccagctga ttacacgccg tatccgtgaa ttcggtgttt acagcgagct 642421 gcatccacat acattgacgg ctgaagaaat taaaaaaatg aatccaaaag gaattatttt 642481 atccggcggt ccaaacagtg tgtatgatga aaactctttc cgctgtgacg agaaaatctt 642541 cgagcttgat attcctgttt tgggaatttg ctacggcatg cagctgatga ctcattacct 642601 tggcggtaaa gttgaagcgg caagccagcg tgaatacgga aaagcaaaca tccgcatcga 642661 aggcacacct gatttgttca gagatcttcc gaatgaacaa gtggtttgga tgagccacgg 642721 cgatttggtt gtagaagttc ctgaaggctt cactgttgac gcgacaagcc atcactgccc 642781 gaactcagca atgagcaaag cggacaaaaa atggtatggc gttcagttcc acccggaagt 642841 gcgccactct gaatacggca atgatcttct gaaaaacttt gtattcggtg tttgcgaatg 642901 cgaaggcgaa tggtcaatgg agaactttat cgaaatcgaa atgcaaaaaa tccgtgaaac 642961 ggtcggagac aaacaggttc tttgcgcgct aagcggcggc gttgattcct ctgttgttgc 643021 tgttttgatt cataaagcga tcggcgacca gctgacttgt atctttgtag accatggtct 643081 tctccgtaaa ggcgaagctg agggtgttat gaaaacattc agcgaaggct ttaacatgaa 643141 tgtgattaaa gtagacgcaa aagatcgatt cttaaacaaa ctaaaaggcg tttctgatcc 643201 tgagcaaaaa cgcaaaatca tcggtaatga attcatttac gtgtttgatg atgaagcgga 643261 caagctcaaa ggcatcgact accttgcaca aggtacgctt tacacagata tcatcgagag 643321 cggtacagca acggcgcaaa cgatcaaatc tcaccacaat gtcggcggac ttcctgaaga 643381 catgcagttt gagctgatcg agccgttaaa tacgctcttc aaagacgaag tgcgcgcgct 643441 tggcacagag ctcggcattc cggatgaaat cgtatggcgt cagccgttcc caggaccggg 643501 actcggaatc cgcgttcttg gcgaagtaac agaagaaaaa cttgaaatcg ttcgtgaatc 643561 agatgcaatc ttgcgtgaag aaattgcaaa tcacggctta gagcgtgata tctggcaata 643621 cttcactgtt cttcctgaca tccgcagcgt tggtgttatg ggtgacgcaa gaacatatga 643681 ttacacaatc ggaatccgcg ccgttacatc aatcgacggc atgacatctg actgggcgcg 643741 tatcccgtgg gatgtgcttg aagtcatttc gacacgtatc gtaaacgaag tgaagcacat 643801 taaccgcgtg gtgtatgata ttacaagtaa gccgcctgcg acgattgagt gggaataaga 643861 atcaattaat ggaaaccatc tttttggcaa ttttgccggg aagatggttt tatttgttta 643921 ttacgaacaa aatccgattt tgcgcgacta ttgttcgctt tttgtattgt tttttcaaaa 643981 tgaacttggt acaatagaca cagaaatcaa ataagatgaa ttcgtataat cgcgggaata 644041 tggctcgcaa gtctctacca agctaccgta aatggcttga ctacgtaaac atttctttcg 644101 tttgatataa ataaaacacg gttatttatt caaactgaaa tccgtctgta gtcaagcgtc 644161 ccaaaatgta ttgggacgtt ttttatttgg cgttttcagg acagaataaa tagcaaagag 644221 tgaagggagt caaatagctt gaaaacgttt tttcagtttg atgagctggg caccagctat 644281 cgcaatgaaa tcattggcgg attaacgact tttttatcta tggcatatat tttgttcgtc 644341 aatccgatta cgcttgcttt ggagagcgtg aaagattttc cggaggcgct gagaattgac 644401 cagggtgcgg tctttacggc gacagcgctg gcgtctgcag caggctgtat cttaatggga 644461 ttaatagcga gatatccgat tgccatcgcg ccgggtatgg ggctgaacgc gttttttgcg 644521 ttttctgttg tccttggtat gggtatttca tggcaggcag ctttgtccgg tgtttttatt 644581 tcaggtctta ttttcgttgc tctttcttta acaggttttc gtgaaaaaat catcaacgcc 644641 attccgcctg agctgaaatt ggcagtcggt gcggggatcg gcctgtttat tacatttgtt 644701 ggattacaag gttcaggaat cattacagcg aatccttcta cgctcgtcac gatcggaaac 644761 attcacagcg gtcctgtgct gttaacgatt ttcggtgtga ttgtcacggt tattttaatg 644821 gtgcttcgcg tgaacgcagg cgtgtttatc gggatgctat taacagcggt agccggcatg 644881 attttcggtt tggttccggt tccgactcaa attatcggca gtgtgccaag ccttgcgccg 644941 actttcggac aagcgtggat tcacctcccg gatattttct ctgtacaaat gctgatcgtt 645001 attttaacat tcttgtttgt cggatttttt gatacagctg gtacacttgt tgctgtggca 645061 acacaagctg gtttaatgaa ggaaaacaaa ttgccgcgtg cgggccgtgc gcttttagct 645121 gattcatctt ctattgtgat cggtgccgtg cttggtacgt ctacaacaac ttcttacgtg 645181 gaatcaagct caggtgtcgc tgcgggtgcc cggtcaggat ttgccgcaat tgtaacaggg 645241 attctctttt tactggctac gtttttctcg ccgctcctat cagtcgttac gtcaaatgta 645301 acagcgccgg cgcttattat tgttggtgca ttgatggtgg cgccgcttgg caaaatcgct 645361 tgggataagt tcgaagtggc cgttcctgct ttccttacca tgatcatgat gccgttaacg 645421 tacagcatcg cgactggtat tgccatcgga tttattttct atccgattac aatggtgtgc 645481 aaaggaaaag caaaagaggt tcatccaatc atgtacgggc tgtttgtcgt atttatcctg 645541 tactttatct tcttaaaata aggaatgaaa aaccagctgc actggcagct ggtttttttg 645601 ttgcaaaaga taaaaccatt tcatacgata taccgtcatg tagatgtgcc gccatgcttt 645661 acttaaatgg aaatgacttg actgttcagg aaggcttcgg taccttatat aagtgtttta 645721 ttttcttgct gaatggtatt ccgccgtatt tttttgatag gagttgctga catgacggaa 645781 gaaagaaaag aaacgtttga agaagaaatt aaccagagtg aaagaataga tgcagatgaa 645841 gaaccgctat cgagaatgtc cagaaaggcg agccggcaaa gcaagcagaa gcaaaaacaa 645901 aagcagaaac cgcgccagga acgcggtgaa tcaactgtta aagacaagct tgcgtctgtt 645961 tgggcagcca tcaacagata ttgcggtttt gcgttctcga ttttaaaatc tccggcgaaa 646021 actgtcgtaa cggatggttt ttctcattat aagtacggtc tgatttcaat gcttatattc 646081 agtatcattt tttcaattgg gaattggttt cagttaaagg caagctggaa tcggccgctc 646141 ggtttcggag aacgccatca tgctttctat gacgggtttt tagttgttct tgtgtatttg 646201 ctgatctttt tcgcggtaat ggtctttgct atatgggctg tctcccgcta tatgatgaag 646261 cagaaggtga cgttcagaga agcggctgcc gtattgggtt cattgcttgt acccgtaatt 646321 gctgtttcaa tcctttggct gatctttgcg atcgtaaata tcccaatgct gacagtactg 646381 tttacggtgc tgatcttgtt ttccatcttt tttatcatcg cgctgtatgt acagcgtgtg 646441 taccaggcgg cacaagatgc accaattgat tatatctatt gtgtatttgc agtagttgcg 646501 atagcgctgc tgtttacggc agtgacttgg ccgtttattt ctgaatatat tacggcgtcg 646561 ttgattccgc tttaatgaaa aaaccggcta atcctagccg gtttttttat gtcacacttt 646621 ttacaaatat atctaaaaaa catagttgat ttgtaggatt aacccgtgta tgatggggaa 646681 aatgctgaaa acgtccagcg caaaaacctt tatgtttaag gaggatgatg gacatggctg 646741 atgtacttcg ccgagcaatt aaccaaaaga agcaattttt aaaaaccaaa ttactgctct 646801 cggaatttta tcaaggaaga ggggaacagc ttgctgacta cacgctgagt gagcttgaga 646861 aagaatacaa gtcccttcag aaaatgaaaa aagagatctg acaatagata taaagaggtg 646921 agtctgctga aaagcgggct tttttgtttt gattttgaaa aggcgagaaa gagggtaaac 646981 tactactgtt caacacataa aagcgtgtcg aaatattttg cttaagctta cgggcgaagc 647041 tgattgtaaa cggctcattt ctctagtaga atatgaatgc tttgtgcaag ctgaagagta 647101 gggggatgaa taaaatgatg caaaccatct tatcaaatgg gatagccatg gttctcataa 647161 ttctcattat taatattgtc tatgtgtcat tttttacgat aagaatgatt ttaacgctga 647221 aaggacagcg ttatttagcg gccggcatca gtacgattga aatactggtt tatgtgacag 647281 gactgagtct ggtgctcgat aacttagacc agattcaaaa tgtgatcgcg tacgcgctcg 647341 gttacggtct tggcgtaatt gtcggcatga aaatagaaga aaaattggcg cttggctata 647401 ttatggtcaa tgtgattacg aaggagctcg atcttgatct tccgaagcag ctccgtgaaa 647461 aaggctacgg cgtgacaaac tgggtggcag gcgggcttga aggcgaccgc acagcccttc 647521 agatcctgac gccgagaaga tatgaactcc agctatatga tacgattaaa acacttgatt 647581 caaaagcctt tattattgcg tacgaaccaa aaacaatcca cggcggcttc tgggtcaaag 647641 cggtgaagaa gaggagaatt aaagaataat ggcaaagccg aagaagaaaa agtttgaagt 647701 gacagagcag caaacgattg atgcggtgct tcagcaaatg aaagaagaag gatatctgcc 647761 tgtaaggcga atggaagagc ctatttttat ggaaaaaaag gaaaatgggt caattcagat 647821 cgttccgtgc gggaaaaaaa tcgtatttga agggaaattg atctaaaaca cgaacattag 647881 tagaatgaat ttttgtatcg ttcgataata tcgttgacat tatccatgtc cgttgttaag 647941 ataaacatga aatcaaaaca cgacctcata taatcttggg aatatggccc ataagtttct 648001 acccggcaac cgtaaattgc cggactatgc aggaaagtga tcgataaaac tgacatggat 648061 atatcgcaga agcgaacgac tgacgataca tgtaccatgc ccggtttgta ttgcttcctc 648121 ataagtgcaa tgcagagcgg gtatttttta ttttctgaaa acaaaagcat tagaaggtgg 648181 ggaacagaat gcagccgcta gtaggaatca tcatgggaag cacttccgat tgggagacaa 648241 tgaaacacgc atgcgacata cttgacgaac tcaatgttcc gtacgaaaaa aaggtcgttt 648301 ccgctcaccg gacgcctgat ttcatgtttg aatatgctga aactgctaga gaaagaggca 648361 tcaaggtgat tattgccggt gccggaggag cggcgcatct gccagggatg acggctgcga 648421 aaacaacact gccagtcatt ggagttccgg ttcagtccaa ggcgctgaac ggaatggatt 648481 cacttctttc catcgtccaa atgcctggag gcgtgcctgt tgcgacaaca tccatcggca 648541 aagcgggtgc tgtgaacgca ggcctgttag cggcgcaaat tttgtcagca tttgacgaag 648601 accttgcccg taagctggat gagagaagag aaaatacaaa acagacagtg ttagaaagca 648661 gtgatcagct tgtctaaaca aatcatctat ccgggagctg taatcggcat tatcggcggc 648721 ggccagcttg ggaaaatgat ggctgtgtcc gccaaacaaa tggggtataa agtcgcggtc 648781 gttgatccgg tgaaagattc gccgtgcggg caggttgcgg atgtcgaaat taccgctcat 648841 tataatgacc gtgaagcgat tcgaaaattg gctgaaatca gcgatatcat cacatatgag 648901 tttgaaaaca tcgactatga tgcgctgcat tggctaaaag atcatgcgta tctcccgcaa 648961 ggaagtgagc tgctgcttat tacccaaaac cgtgaaacag agaaaaaagc aattcaatcc 649021 gcgggctgtg aagtcgcacc gtacagcatc gtcaaaacaa agaatgaatt gaaacaggca 649081 gtacaggagc tcaggcttcc ggcagtgctg aaaacatgcc gcggcgggta cgacggcaaa 649141 ggccaatttg tgataaaaga agaggcgcaa atggagcagg cagccgctct gttagaacac 649201 ggaacttgca ttcttgaaag ctgggtttct tttaaaatgg aactgtcggt gatcgtcgtt 649261 agatcggtaa acggtgaaat ttcaacattt ccgacagctg aaaacattca ccacaacaat 649321 attcttttcc aaagcatcgt gcccgcacgg gtagagaaag ggattcagca gaaggctgct 649381 gatctcgcag ttaagcttgc agatgagctt aaccttgtcg gaccgcttgc tgttgagatg 649441 ttcctgacag aggacggaga gcttttggtc aatgaactgg cgccaagacc gcacaattca 649501 gggcattata cgctggacct ttgcgagacg agccagtttg agcagcatat cagagcggta 649561 tgcgggcttc cgcttgggaa gacagatttg ctgaagccgg gcatgatggt gaatcttctc 649621 ggcgatgaag tgaagcttgt tgaggaagac ccggagcttt taaaagaggc aaagctatat 649681 atatacggaa aacatgaaat caaaaaaggc cgcaaaatgg ggcatattac atttatgaag 649741 cagcctgaag acgaatggat tcaggagatc acaaataaat ggatgaatag agacggagga 649801 caagcagaat gatcgaacgt tattcaagac ctgaaatgtc cgcgatttgg acggatgaaa 649861 acagatttca agcatggtta gaggttgaaa ttcttgcctg tgaagcgtgg gcggagcttg 649921 gcgtcattcc gaaagaagat gtaaaggtta tgcgcgaaaa cgcgtcattt gacatcaacc 649981 gcattttaga aatcgaaaag gacacgcgcc atgacgttgt cgcttttacg cgcgctgtat 650041 ccgaatcact gggcgaagaa agaaaatggg tgcattacgg cttaacgtca actgacgttg 650101 ttgatacggc tctttcctac ttattaaaac aggcaaacga tattttgctc aaggatcttg 650161 agagatttgt tgacattata aaagaaaaag cgaaagaaca taaatacaca gtcatgatgg 650221 ggcgcacaca cggcgtacac gctgagccta caacattcgg cttaaaactt gcgctttggc 650281 atgaagaaat gaaacgtaat cttgagcgct tcaaacaagc gaaagcaggc atcgaggttg 650341 gaaagatttc cggtgctgtc ggcacatatg cgaacattga tccatttgtt gaacaatatg 650401 tctgtgagaa gctcggattg aaagcagcac cgatttccac tcaaaccctt cagcgtgacc 650461 gccatgctga ctatatggca acacttgctt tgatcgcgac aagcatcgag aaattcgctg 650521 tggaaatccg cggactgcaa aagagtgaaa cacgtgaagt agaggaattt ttcgcgaaag 650581 ggcaaaaggg ttcatctgca atgccgcata aacgaaatcc gattggctct gaaaacatga 650641 caggcatggc gcgcgtgatc cgcggctaca tgatgacagc ttacgaaaat gttccattat 650701 ggcatgagcg cgatatttct cattcttcag cagaacgaat tattcttccg gatgcgacaa 650761 ttgcgctgaa ctacatgctg aaccgcttct ccaacatcgt gaagaactta acggtcttcc 650821 cggaaaacat gaagcgcaac atggaccgca ctctcggcct tatctattct cagcgtgtgc 650881 tccttgcttt gattgacaca ggcctgactc gtgaagaagc ctatgataca gttcagccga 650941 aagcaatgga agcgtgggaa aaacaagtgc cgttccgcga gcttgtggaa gcggaagaga 651001 aaatcacgtc acgtctttct ccagaaaaaa ttgctgactg ctttgattac aattaccatc 651061 tgaaaaatgt tgatctgatc tttgaacgtt taggtttagc atagaagaag cttttagcgg 651121 cttcttctaa gccgccgcag tttgaaaatt cccaacattc gggttaggag gccttccgtg 651181 aatattgtga agaatgaact tttatacgaa ggaaaagcaa aaaagatcta caaaaccgat 651241 gacgaaaaca cgctgtatgt cgtgtataaa gactccgcca ctgcctttaa cggcgagaaa 651301 aaagcagaaa tcagcggaaa agggcgctta aataatgaaa tttcaagcct cattttcaaa 651361 caccttcatg ctaagggcat taacaatcat tttatcgagc gcatttcgga aacggagcag 651421 ctcattaaaa aggtaacgat tgtgccgctt gaagtcgtgg taagaaatgt tgtggcagga 651481 agcatgtcca aacgtctcgg cattccagaa ggcacggagc ttgagcagcc gattatcgag 651541 ttttactaca aggatgacgc gctgggtgat ccgctcatca cagaagatca tatttggctt 651601 ttgaaggcgg cgactcctga gcaggtagaa accattaagt ccattacaac aatagtaaat 651661 gaagagcttc aaagcatctt cgacgattgt catgtcagat taatagattt caagcttgaa 651721 ttcggtttag atgcagaagg gcaagtgctt ttggcggatg aaatatctcc tgacacatgc 651781 cgcttgtggg ataaagaaac gaacgaaaag ctggacaaag atttattcag acgcaatctg 651841 ggaagcttaa ccgacgcata cgaagagatt ttcaatagac tgggaggcat tcatcatgta 651901 taaagtaaaa gtttatgtca gcttaaaaga aagtgtacta gatccacaag ggagcgctgt 651961 ccagcatgcc ttgcacagta tgacttacaa cgaagttcaa gatgtgcgca tcgggaaata 652021 catggagctt accattgaaa aatctgaccg tgatcttgac gtgctagtga aagaaatgtg 652081 cgaaaaactt cttgcgaaca cagtgattga agattataga tatgaggttg aggaggtagt 652141 cgcacagtga aatttgcggt gattgtgtta cccggctcca actgtgatat cgatatgtat 652201 catgctgtaa aggatgagct cggccatgaa gtggaatacg tctggcatga ggaaacaagc 652261 cttgacggct tcgacggcgt gttaattccg ggaggatttt cttacggcga ttacttaaga 652321 tgcggcgcca tcgcccgatt tgcgaatatt atgccagctg tcaaacaagc agcggctgaa 652381 ggaaaacctg ttcttggcgt ctgtaacgga ttccagattt tacaggagct tgggctgctg 652441 ccaggcgcaa tgagacgcaa caaagatctg aagttcattt gccgtccggt tgaattgatt 652501 gttcagaacg acgaaacctt attcacagct tcctacgaaa agggagaatc gattacaatc 652561 ccggttgccc atggtgaagg gaatttctac tgtgatgacg agacgcttgc tacattaaag 652621 gaaaacaatc aaattgcttt cacatacggc tctaatatta atggaagtgt cagcgacatt 652681 gccggtgtcg tgaatgagaa aggcaatgta ttaggcatga tgcctcaccc tgagcgcgcg 652741 gtcgatgaac tgcttggaag cgccgacggt cttaaattgt tccagtctat cgtgaaaaat 652801 tggagggaaa ctcatgtcac tactgcttga accaagtaaa gaacaaataa aagaagagaa 652861 actgtatcag caaatgggtg tcagtgatga tgagtttgca ttgatagaat ccattcttgg 652921 aagattgccg aactacacag aaatcggaat tttttctgtc atgtggtctg agcattgcag 652981 ctataaaaac tcaaagccga ttctgcgtaa attcccgaca agcggcgagc gtgtgctgca 653041 ggggccgggg gaaggcgccg gaatcgttga tatcggtgat aaccaagcgg ttgtgttcaa 653101 aattgaatca cataaccacc catcagctct cgagccttac caaggcgctg cgactggcgt 653161 aggcggaatt atccgtgatg tattctcaat gggtgcacgc ccaatcgctg tattgaactc 653221 tcttcgattt ggtgaactga cttcaccccg cgtgaagtac ttgtttgaag aagtagtagc 653281 gggtatcgcc ggatacggca actgtatcgg catcccgaca gtcggcggag aagtgcagtt 653341 tgacagcagc tatgaaggaa atccgctcgt caacgcaatg tgcgtcggtt taatcaacca 653401 tgaagacatc aaaaaaggcc aggcaaaggg tgtcggcaac acagtaatgt acgtaggagc 653461 gaaaacaggg cgtgacggca tccacggcgc tacgtttgct tctgaagaaa tgtcagactc 653521 gtctgaagaa aagcgttctg ctgtccaagt cggcgatccg tttatggaga agcttttgct 653581 tgaagcatgt ctggaagtca tccaatgcga cgccttagtc ggcattcagg atatgggagc 653641 tgccggttta acaagctcaa gtgcagaaat ggcaagtaaa gccggttctg gcattgaaat 653701 gaatcttgac ctgattcctc agcgcgaaac aggcatgacc gcgtatgaaa tgatgctttc 653761 tgaatcacaa gaacggatgc ttttggttat tgagcgcgga cgtgagcagg aaatcatcga 653821 tatttttgac aagtatgatc ttgaagcggt ttctgtcgga catgtgacag atgataaaat 653881 gcttcgcctg acacataaag gagaggttgt gtgcgagctg cctgttgatg ccttggcaga 653941 agaagcaccg gtttaccata agccttctca agagcctgct tactatcgcg agtttttgga 654001 aacagacgtt ccggctccgc aaattgaaga tgcgaatgaa atgctgaagg cccttcttca 654061 gcagccgacg attgcgagta aagagtgggt ttatgatcag tatgactaca tggtgcgcac 654121 gaatacagtt gtcgctcctg ggtctgatgc tggtgttctc agaatccgcg gaacgaaaaa 654181 ggcgctggcg atgacgacag actgtaacgc gcgttatctc tatcttgatc ctgaagtcgg 654241 agggaaaatt gctgtcgctg aagcagcgcg caacatcatt tgctcaggcg cagaaccgct 654301 tgcggtgaca gataacctta acttcggaaa ccctgagaag ccggaaatct tctggcagat 654361 cgaaaaagcg gcagacggca taagcgaagc gtgcaatgtt ctcagcactc cggttatcgg 654421 cggtaacgta tcgctttata acgaatcaaa cggcacggcg atctatccga caccagttat 654481 cggcatggtc ggcctaattg aagatacagc gcacattaca acacagcatt tcaaacaagc 654541 aggagatctc gtatacgtga tcggcgaaac aaaaccagag tttgccggaa gcgagctgca 654601 aaaaatgaca gaaggccgta tttacggcaa agcgccgcaa atcgatcttg atgtagagct 654661 gtctcgtcaa aaagcactgc ttgacgcgat taaaaaaggc ttcgttcaat ctgcgcatga 654721 tgtgtctgaa ggcggcttag gcgtagcgat tgcggaaagt gtcatgacga cggaaaacct 654781 tggcgctaat gtgactgtag aaggggaagc ggcgttatta ttctctgaat ctcaatctcg 654841 cttcgtcgtt tcagtgaaaa aagaacatca agctgcgttt gaagcaactg tcaaagatgc 654901 agttcatatt ggtgaggtaa cagctgacgg aattctggcg attcaaaacc aagacggaca 654961 acaaatgatt catgcgcaaa cgaaagagct tgaacgcgta tggaaaggag ctatcccatg 655021 cttgctgaaa tcaaaggctt aaatgaagaa tgcggcgttt ttgggatttg gggacatgaa 655081 gaagccccgc aaatcacgta ttacggtctc cacagccttc agcaccgagg acaggagggt 655141 gctggcatcg tagcgactga cggtgaaaag ctgacggctc acaaaggcca aggtctgatc 655201 actgaagtat ttcaaaacgg cgaactcagc aaagtaaagg gaaaaggcgc tatcgggcac 655261 gttcggtacg caacggctgg aggcggcgga tacgaaaatg ttcagccgct cctcttccgt 655321 tcccaaaaca acggcagcct ggcgcttgct cataacggaa atcttgtcaa cgccactcag 655381 ctgaagcagc agctcgaaaa tcaagggagc atctttcaaa cctcttcgga tacagaggtt 655441 ttggctcacc tgatcaaaag aagcggacac ttcacgctga aggatcaaat taaaaactcg 655501 ctttctatgc tgaaaggcgc ctacgcgttc ctgatcatga ccgaaacaga aatgattgtc 655561 gcacttgatc caaacgggct gagaccgcta tccatcggca tgatgggcga cgcttatgtg 655621 gtcgcatcag aaacatgcgc atttgacgtc gtcggcgcaa cgtaccttcg cgaggtagag 655681 ccgggagaaa tgctgatcat taatgatgaa ggcatgaaat cagagcgttt ttccatgaat 655741 atcaatcgtt ccatttgcag catggagtac atttatttct ccagaccaga cagcaatatt 655801 gacggtatta atgtgcacag tgcccgtaaa aaccttggga aaatgctggc tcaggaatcc 655861 gcagttgaag ctgacgtcgt aaccggggtt ccggattcca gtatttcagc ggcgatcggc 655921 tatgcagagg caacaggcat tccgtatgag cttggcttaa tcaaaaaccg ttatgttggc 655981 agaacgttta ttcagccgtc ccaggctctg cgtgagcaag gcgtcagaat gaagctgtct 656041 gcggtgcgcg gggttgtaga aggcaaacgc gtcgtgatgg tggatgactc tatcgtgcga 656101 ggaacaacta gccgccggat tgtcacgatg ctaagagaag cgggtgcgac agaggtgcat 656161 gtgaaaatca gttcaccgcc gatcgctcat ccgtgctttt acggcattga cacttccaca 656221 catgaagaac tgatcgcgtc ttcgcattct gttgaagaaa tccgtcagga aatcggagcc 656281 gataccctct catttttgag tgtggaaggg ctgctgaaag gcatcggcag aaaatacgat 656341 gactcgaatt gcggacagtg tctcgcttgc tttacaggaa aatatccgac tgaaatttac 656401 caggatacag tgcttcctca cgtaaaagaa gcagtattaa ccaaataaaa cttgaaaaat 656461 gacataaagg cagcgcagtt cggctgcctt tctctttctg ccctcgttcg gggagatatt 656521 ttgaaaagcg ccttaaagga gtgaatagga tgtctgaagc atataaaaac gcaggagttg 656581 acatcgaagc cggatatgaa gctgtaaaac gaatgaaaaa acacgtggag cgcacgaaac 656641 ggcttggcgt tatgggcagc cttggcggtt ttggcggcat gtttgacctg tctgagcttt 656701 cttatcaaaa accagttctc atttcgggaa cggacggtgt cggcacaaaa ttaaagctcg 656761 ctttttccat ggataagcat gacacgattg gcgtggatgc tgttgcaatg tgtgtcaatg 656821 acgtgctggc acaaggtgca gagccgctgt ttttcctcga ttatttagcg gttggcaaag 656881 cggacccagt gaaaattgaa cagattgtac aaggtgttgc ggaaggctgt gagcagtcag 656941 gttcagcctt agtcggcggt gaaacggctg aaatgccggg gctctataca gctgatgaat 657001 acgatattgc cggtttctca gtcggagtgg cagaaaagga cgaaatcgtg actggagaaa 657061 aaattgaaga gggccatctg ttgatcggcc tcagctccag cggccttcac agcaacggct 657121 tttcccttgt cagaaaagtg cttctggatg atgcggagct ggacctcgat acaacatatg 657181 agccgtttga acgcccgctt ggcgaggaat tgcttgaacc gacaaggatt tacgtgaagc 657241 ctgtgcttgc cgcggtcaaa agcggaaaaa tcgacggcat ggcgcacgtg acaggcggag 657301 gatttattga aaatattccg cgtatgcttc cggaaggctt aagtgcggaa attgatcatg 657361 gctcatggcc gatcccgccg attttttctt tcttgcaaga gtacggcaag ctaaaggaag 657421 aagacatgtt caacgtcttt aatatgggta tcggttttgt tttggcagtc aaagaagagc 657481 atctgacaga tgtgatcgga acgcttgaaa gccatggcga aaaagcctat ttaatcgggc 657541 gtgtgaaaaa aggtgaaggc gtcacattcg gcggtgcggc actttcatga aaaagtttgc 657601 ggtatttgca tcaggaaacg gttcaaactt cgaagccatc gtcacgcgtt tgaaggagga 657661 gaactgggat gcgtcagcag cgctcctcgt ttgcgacaaa ccgcaggcga aagtcatcga 657721 acgggcggaa gcattccaca ttccatcctt cgcatttgag ccgaagtctt atgaaaacaa 657781 ggctgcattt gaacaagcca tcattgaaca gcttcgtctt cacgaggttg aattgattgc 657841 tcttgccggc tatatgaggc tgatcggtga tacgctcctt caagcatatg ggggaaaaat 657901 cattaacatt cacccatcgc ttcttccggc gtttcctgga atcgacgcag tcggacaggc 657961 gttccgggcg ggtgtgaagg tggccggaat caccgtgcat tatgtcgatg aaggaatgga 658021 tacaggtccg atcatcgctc aaaaggcaat cgaaattgat gaacatgata cattggaaac 658081 aatcgaacag cgaattcaca agcttgagca taaatggtat ccgagtgtga ttaaacagct 658141 attaggatta aataacagag gtgaaaaggc atgaccatta aacgtgcatt aatcagtgtt 658201 tcagataaaa caaatctcgt tcctttcgta aaagaactga cagagcttgg cgttgaagtc 658261 atctccacag gcggaacgaa aaagcttctt caagaaaacg gtgtggatgt gatcggaatt 658321 tctgaagtga caggctttcc tgaaattatg gacggccggt taaaaaccct acacccgaat 658381 attcacggcg gccttctggc ggttcgcggc aatgaagagc atatggcgca gatcaatgaa 658441 cacgggattc agccgattga cctcgttgtc gtcaacctct atccatttaa agaaacgatt 658501 tctaaagaag acgtcacgta tgaagaagcg atcgaaaata tcgacatcgg cggacctggc 658561 atgctgcgcg cggcatcaaa gaaccatcag gatgtcacgg ttatcgtcga tccggccgat 658621 tacagcccag tgctaaatca aatcaaagaa gaaggcagcg tatctcttca gaaaaaacgc 658681 gagctcgcgg caaaagtatt ccgtcatact gcggcatatg atgcactgat cgctgactat 658741 ctgacaaatg ttgtcggtga aaaagaacca gagcaattca ctgtgacatt tgagaaaaaa 658801 caatcgcttc gctatggaga aaacccgcat caggaagcaa ctttctatca aacagctctt 658861 cctgtcaaag gctccattgc gcaagcagaa cagcttcacg gaaaagagct ttcttacaac 658921 aacattaaag acgcggatgc tgcagttcaa atcgttcgtg aattcactga accggctgct 658981 gttgctgtga agcatatgaa cccgtgcggc gtgggaacag gaaaaacgat cgcagaagcg 659041 tttgacagag cgtttgaagc ggataaaaca tctatcttcg gcggcattat cgcgctgaac 659101 cgtgaagtgg acaaggcaac tgccgaagcg cttcacaaca ttttcttaga aatcatcatt 659161 gcgccttcat tcagccaaga agcgctcgac gtcctgactg cgaagaaaaa tctccgtctg 659221 ctgacgcttg acgtatccgc cgctgttcaa aaggaaaaac agctgacatc cgttcaaggc 659281 gggctgctga ttcaagattt agatatgcac ggcttcgatg atgctgagat tagcattccg 659341 acaaaaagag agccgaacga gcaagagtgg gaagacttga agcttgcttg gaaagtcgtg 659401 aagcatgtga aatcaaatgc gattgttctc gcgaaggaca acatgacagt cggcgtggga 659461 gcaggccaaa tgaaccgcgt cggatcggca aaaatcgcaa tcgagcaagc aggggaaaaa 659521 gcgaagggca gcgcgctcgg ttcggatgca tatttcccaa tgccagatac tgtcgaagaa 659581 gcggcaaaag cgggcgttac agccatcatt cagccaggcg gatcgatccg agatgaggat 659641 tccatcaaaa aagcggatga atacggcatt gccatggtat tcaccggcat cagacacttc 659701 aaacattaag gggatgaaaa cgacgtgaat gtattaatta tcggtaaagg cggaagagaa 659761 catacgctgg cgtggaaggc agcgcaaagc agcctcgtcg agaatgtatt tgccgctccc 659821 ggaaatgacg gcatggcagc ttccgctcag cttgtaaaca ttgaggaaag cgaccacgca 659881 gggcttgtct catttgcaaa acaaaatcag gtcggcctga ccattgtcgg ccctgaggtt 659941 cctttaattg aaggtctggt ggatgaattc gaaaaagcgg gcttacatgt gttcggtccg 660001 tcaaaagctg cggcgatcat cgaaggaagc aaacagttcg ctaaggattt aatgaagaaa 660061 tacgacattc cgaccgcaga atacgagacg tttacatcct ttgatgaggc gaaggcatat 660121 gtgcaggaaa aaggtgctcc gattgtgata aaagcagatg gacttgcagc tggaaaaggc 660181 gttactgtgg ctatgacaga ggaagaagca attgcgtgct tgcatgactt tcttgaagat 660241 gaaaagttcg gtgatgcgag cgcgtccgtt gtcattgaag aatatctttc tggtgaagaa 660301 ttttctctaa tggcctttgt caaaggggaa aaggtgtatc cgatggtgat tgcccaggat 660361 cacaagcggg cgtttgacgg agacaaaggc ccgaatacag gcggcatggg cgcctactcg 660421 ccagttccgc aaatttcgga agaaacggtc cgccatgctg tagaaacgat cgttaagccg 660481 gctgcaaaag caatggtaca agaaggccgt tccttcactg gcgttttgta cgctggattg 660541 atgcttactg aaaacggctc gaaggtcatt gaatttaatg cccgtttcgg cgatccggaa 660601 acacaggtcg tgcttccgcg catggaatct gatctggtac aggtgcttct tgatctttta 660661 gatgataagg aagttgactt aagatggaag gataccgcgg cagtgagtgt tgtgcttgca 660721 tcagaagggt atccggaaag ctatgcaaaa ggcacgccga tcggcagcct tgcagcagaa 660781 actgagcagg tcgtggtctt ccatgccgga acgaaagcag aaggtggaga gttcgttaca 660841 aacggggggc gcgtcgccaa tgtgacggct tttgatgaaa cgtttgaagc ggctagagac 660901 cgagtgtaca aagcggttga tgaaattttc aaaccgggac tctttttcag aaaagacatt 660961 ggggcacgcg ctttaaaggc tgcccaaaaa taagtgagga aaacccgcag aatagctgcg 661021 ggttttttgt tatcaaaaag cgggatggca gctagaagaa gaaagcacaa cgagcgtggt 661081 tggttttcca tgggccatcg aggtgtcaat aaaatcctca agcgtatgta ccgattcagt 661141 cacgaccttt gtcacatagc tgtacatccc cgtgatgcgg tggttttctg ctacatcagg 661201 atgcgatgtt gcaaaggcgg cgtagtgctt gcagcttttc ggctccatga gaataaaagc 661261 ggtgacatgc ttgtttagtt tttcgtaaca gatattcgcg ctgtagccgg taatcactcc 661321 tttgtcttcc agcttcctga cacgctccgc cgcgcttggc gagctgagtc cgacaagctt 661381 tcccagctca accatcgtta atctgccgtt tcgctgcaaa tgcgagagaa tctgaaggtc 661441 tgtatcgtcc atttgtctgg ctcctttaca tatttaggcg aatgaatgaa aattcctttg 661501 atcgtaaggt aatgctgttg atttaacttc attgtagcat atggatgccg tcttattttt 661561 tctataataa agccatcaat cagagagggg gcatcatgtt gccagaattg cagcgctcta 661621 ttacttggat acaagggacg gcgttaacga ttggggcggt tttaggatgc gggatattaa 661681 tcctgccgtc tgtcaccgcg gacacggccg gccccgcttc tttatttgtt tgggtgttca 661741 tgtccttctt atcctttttt cttgtcggca cgctggcccg gcttgtgaaa atagcgccta 661801 gcgcgggagg aatcacggct tatgtgcagc tggcctttca gaaaaaagcc ggggctattt 661861 tgggctggat catgttaggg tccgttccga tcggcgttcc catcatcgct ttgactggcg 661921 cgcattacgt cagttacatc acagaggcgg ccgattggca gattacattg attgctggtt 661981 gcatgctggc tatatctatt ttgcttcata tgagagggat tcaactatca gcaaacatta 662041 gtacactcgt tatatgtgtc atcgtatttc tgcttgtcac ttctattgct gtgtcattgc 662101 cacacgtcac gatagcagaa ttcaagccgt ttcttccgca tggctggtct gccgctggat 662161 ctgtttctgt tatgattttt ttctcttttg taggctggga aatgattacc ccgttggctg 662221 aggaatttca tcgtcctgaa aaagatgtcc cgctcagctt gtttttggca gcgtcttgtg 662281 tggcggggct gtatatcatg ctgtcatttg tgaccgtggg tactcattca tatggagaga 662341 atggagaaat tgcatcgctt gccatgctca tttcaaaagg agcaggagaa agcggtgtat 662401 atgtcacggt atgtttagcg ctgtttatta cattcgccac catccatgcc aatattgccg 662461 gtttttcaag aatggtgtac gcattggcga gagaggggca catacccgta ttttttggaa 662521 aactcagtgc gacaaaacgt acgcctattc gcgttttgac agcgatggcc gcagtgtttg 662581 gcttagtgct tgcagcgcat ggtctgtttc aaatcgattt gacgactctg ttgaaagggc 662641 cgagcgcggc ttttatcgca tcttacatat gtacaatggc ggcagcactg aaactgctgg 662701 gcaggagaga tataggctgg tggatggcgc tcggggcatt tgtggcgtgc gcggtgattt 662761 attcattcag cggctgggca ctgctttatc cggcagtgct ggcagctgca ggatatttct 662821 atatgaaaac aaagggtggg cataaaaaaa agcttgatca cgttttgtga tcaagctttt 662881 ccatttatcc gttttgatgc tcgttatttc cagaatcgct gtgttgaaac atgtaggtca 662941 caggacagaa gcgcaagatt cccgaacccg ctttcatggc ccccataaag atgtaaaaga 663001 gatgcattct gcaccaaggt tttttcgtaa actttgcact ggcggctgac ataatcgtca 663061 atccgcaggc gattctgaac acggcattga tgagactgat gtttggcttc aaggaaatcc 663121 gctcctttta cttaaaaaag ttttttaatc gaaccttcaa aaatttgtaa cgtttttatc 663181 gtgcgtgatg aggaaggatg tgataccatg agtctaatac atgtaaagga gagtatgtga 663241 atgtccgaac gcacctttaa ctggaaaaac aaagacatca gggcacaggt tgatgttgta 663301 gactcaaagc tgcttccaac gctcctttta cggaatgctc tcgtcttaaa tccatatgta 663361 aaacaatggc tgaaaaaaaa catttggatt tatcaggacc gcattgttta tgtgggtcat 663421 gaacttccga atagagccga agaaattcat acgattgatt gtgaaggaaa atacattgtg 663481 ccaggttata ttgaaccgca cgcacatcct tttcaaatat ataatcccca aacactggcg 663541 gaatatgtgt ctcaatacgg aacaacgaca ttcgtgaatg ataacttatt tttgcttttg 663601 caaagcggaa aaaagaaagc gcttacgatt ttgaatgaac tcaaaaagca gcctgtccag 663661 tatttttggt ggtcacgcta tgacctccag accgaggttc tgaacgagga ccacgtcctt 663721 ccatttgacg tcagaaaaca gtggattgaa catccggatg tgattcaagg cggagaaatg 663781 accggatggc ctcgcctggt agatggtgat gatttaatgc tccactgtat gcaagctaca 663841 aagaaacaga gaaaacgtat tgaagggcat tttcccggcg cttctgataa aacgcttaca 663901 aaaatgaagc tgttcggtgc ggattgtgat catgaagcga tgacaggtga tgaagtgatg 663961 agaaggctgg aactgggcta ttatgtttcc cttcggaact cttccattcg ccccgatgta 664021 agaaaaatct tgcaagagct gcatgagaag ggcttccgct attatgacca cttcttttac 664081 acgacagatg gcgcaacccc gaatttctat aaaggcggca tgacaaacga gctgattcgc 664141 attgcgttag aagaaggcgt acctgcaatc gacgcctaca atatggcatc atttaatatc 664201 gcaaagtatt accaaatgga tgattattta ggagttgtcg gaccgggcag actggcatcg 664261 ctaaacatac tggaagatcc gttaaatccg aatccagtga ctgttctgtc aaaagggacc 664321 attctgcgtg aaaacggctg tgatttgaag gcgtttacaa agacggactg gcacaaaggc 664381 ggtcttgtcc cgcttgagct ttcatatgat atgacgatgg atgacttgca gttttctatg 664441 ccgatgggcg tgaaaatgcg gaatgcggtt attatggagc catatatgat tgagatcgac 664501 aattcgatgg aacagctctc gtttgaccat gatgaaagtt atttgacgat gctcgacaga 664561 cacgggaaat ggcgcgtcaa tacgatgata aaagggtttg cctcaagcgt gcagggattt 664621 gtaagctcct ttacgacgac gggcgacatt gtcgcgattg gaaaaaataa agcggatatg 664681 ctgctcgctt tcgcccgcat gaaagaaatc ggaggaggaa ttgttttagc ggagaacgga 664741 aacattctgc atgaaatccc gcttgcgctg tgcggctgcg cctcttcgga agcgtatgaa 664801 gacgtgcttg agaaggaaca aaagctgaga gatcttttga ctgaaagagg ctatgagttt 664861 tgcgatccta tctatacgct gctctttttg caaagtacgc accttccgta tatacgcatt 664921 acgccaagag gaatattcga cgtcatgaaa aaaactgtac tctttccatc gataatgcgt 664981 taaaatataa aagagcaggg agccgacata tgaaaaaatg gatgacagtt tgcgcgctgt 665041 gtttcgtgtt ttttctgctg gtatcctgcc agcagaagga tgctgtcccg gatactgcaa 665101 agaagctgaa agctccttta acggggctaa agactgaaca gaaagtgact gaacgccgcc 665161 ctgttgctgt tgtggtgaac aatcacccga aggcgaggcc gcagtcgggt ctgtctaaag 665221 ccgacattgt catagaagcg ctagccgaag ggcaaatcac aagatttctg gccattttcc 665281 aaagccagat gcctgaaact gtcggacctg tgcggagcgc gcgggaatat ttcgtcactc 665341 tcagcaatgg ctttgacagc atatttgtcc atcacggctg gagtcccggc gccaaaaagc 665401 agctggaatc cggagctgcc gattatatga acggattgga ttttgacgga agcttatttt 665461 ggagagctga tttcagcaaa ccgccccaca attcctatac gtcttatgat tacataaaaa 665521 aggcggcaga acaaaagggt tataagctga agcaggaaac aaatccgctg ctgtttcaaa 665581 catcagatgc aaaacctgca aatgaatctt acaatgttcg ggtagattat ggaacaaata 665641 acgttacaaa tcttgtcgaa tacaactatg ataaaaaagc tgaattttat acaagaagct 665701 ctgatggtgt cataacgaca gaccgggaaa ccggaaagcc ggttgcaatg caaaatattt 665761 tcattgttga agccagccat catattattg atcaagatgg aaggcgggac atcgacttgg 665821 aatcaggagg aaaaggtctg ttgtttcagc acggaaacgt cattgaaaca gactggaaac 665881 aagtgaatgg cagaattgtg ccggtaaaag acggcaagtg gcttccgttt gtgccaggaa 665941 agacttggat caatatcgta cctgatcttg atgcggcttc cattagtaaa ggagaaggtg 666001 tgtaacgatg caaatcgata aattacgcgg caaagagctg gaccagttat ttaactcgat 666061 cttatcgctg aaagacctgg aggaatgtta ccgattcttc gatgatctat gcacaattaa 666121 cgaaattcaa tcgctggctc agcgccttga agtggcgcgc atgcttcgcg aaggaaacac 666181 gtatcataag attgaaacag aaacaggcgc ttccacggct acgatttccc gtgtgaaacg 666241 ctgcttaaat tacggaaatg acgcttatga aatggcgctt gaccgtgtga aggagacgga 666301 aacagagtct tcttccaaat aaaaaaccgc cctgccgtct ggcaagggcg gtttctttat 666361 gaaacaaatt gatggatcag gttgtcgata ttgatgatac tgccatcctc tttccgatag 666421 acaacatgct ccttggaaaa atgaatcggc gaattaatcc ctgctgcggc tgcaaggtta 666481 aatagtccct cgcgcaatga aataacgtag ttgcagacac gatgctgttt ttcctcaacg 666541 ctcagtgctt tttgcaattt cggatctgtc gtcgccacac ctgccggaca ggtgttggtg 666601 tggcagacga gagcgcggat gcagccaacg gaaaacatca tgccgcgtgc gatgttaaca 666661 aagtcagcgc cgagggctaa ggcgaccgcg attttatcag gagtcaggag ctttccggaa 666721 gcaaagattt tcagctggct gcgcaagccg tactgtttaa gaagcgtgtc cacaataggc 666781 agcgctgtca taatcggaag gccgactgta tccgcgagct cgtaaaagga agctccggta 666841 ccgccttcac ttccgtcgat cgtgataaaa tccggatgct ttccgctttt ctgcatatga 666901 gagaaaagct catgcaattc ttcaggatgc cctgcgacca gtttgatgcc gactggcttt 666961 tgtccgacat ctctaagttt ttcaataaag tcgagcattt caggagggtt tgagaattca 667021 taaaagcggt tcgggctgtc aatcgacttt ccaggttcga cattccgaat gtctgccact 667081 tcctctgata ctttggcgcc gtccacatgg ccgccgcggg ttttcgctcc ttgtgccagc 667141 tttagctcaa acgctttaat ctggtcaatc ctgctttttc ttttaaattc ctcccacgaa 667201 aattccccgt ttcttttgcg cacgccgaat aggcccggtc cgatttggca aatgatatcg 667261 gcgccgccct ttaagtgata ttcagacaat cccccttcac ctgtattcat ccaggtgccg 667321 cctgccagat ggagcccttt tgagagcgcc gtaacagccc gttctccaag agaaccgtag 667381 ctcatggcag actggccgac taagcccttc acataaaatg gcttctcgca tgtatgctcg 667441 ccaatcacct gtacatcatc aggatggaga aaatacgggt ctgccttgat atgttcggca 667501 tgctccttgc gtttgaacag attgtcagca tccattttat agatttgggt ttcaattttt 667561 ggcgtttgat ttacatgcat ttcttccctt tgttttggaa acatagcgtt acggatataa 667621 tagccaggtt tatcaaaatc tcttacagat ccaaagccca tcattctgct tttgtatttg 667681 ccggagatga cggtttgctc atattccttt cgtgaaaatg gctgctcttc attgtcattg 667741 ctgtataaat actgtctgag ctccggcccg attttttcaa ggatataccg aaaccttccg 667801 atgacgggat agttgcgaag aattgagtgc tcctgctgtt tttcatcctt tatgtagatc 667861 caggcaaaca agacgatcgg gatagcgatg atcccaatga taaatgcgat gagtgctatt 667921 atgatggttt ccatctctca gcctcccttt ttatgtaacc atttccacag tagaacactt 667981 tccaaacaat agcagaagga atctggtgaa aaatgtgtgc tcctgccgat acaggactca 668041 ccatgcaggt actgccatat gctctctttt tttatgaaaa aagaatcaaa acaccttttt 668101 cagtgaataa cgagattaac ggctttttcc gtttttccgc gctatgtgaa tttgttataa 668161 tgtttaaatg gtaacaaacg aatggaggaa cgtatgacgt gtacgatgta acggagtgga 668221 agcatgtctt taaactcgat ccaaataaag atttgcctga cgaacagctg gagattcttt 668281 gcgaatcagg aacggatgcg gtcattatcg gaggaagcga tggtgtgaca gaggataatg 668341 tcctgcggat gatgtctaag gtaagacggt ttttggtgcc gtgtgtccta gaggtatcag 668401 cgattgaagc gattgttccc ggctttgact tatattttat tccgagtgta ttaaacagca 668461 aaaacgcgga ttggattgtc ggaatgcacc agaaagccat gaaggaatac ggagaactga 668521 tgtctatgga agaaatcgtg gcggagggct actgcatcgc aaatccagat tgcaaagccg 668581 cggcactgac tgaagcggac gccgatctga atatggatga tattgtcgcc tatgcgcgtg 668641 tgtcggagct gctgcaactg ccgatttttt atttagaata cagcggcgtg cttggagaca 668701 tagaagctgt caagaaaacg aaggctgtat tggaaacgtc caccttgttt tacggcggcg 668761 gcatcaagga tgcggaaacg gccaagcagt acgcagagca tgcggacgtg atcgttgtag 668821 gcaatgcggt gtatgaagat tttgacaggg ctttgaaaac agtagcggct gtgaaaggcg 668881 agtagtaaat tgtacggatt tggtttatga tagaacgtat gttttgtata ggcgggtgaa 668941 caaattttga attatattag caatcaatta ctaagcggtt taaaccccgt tcagcaggaa 669001 gcagtcaaaa caacggacgg gcctcttttg ctgatggcgg gagcgggtag cggaaagacg 669061 cgtgtcctga cccatagaat tgcttattta atggcagaaa agcatgtggc gccgtggaac 669121 attctggcga tcacatttac aaataaagcg gcacgcgaaa tgaaagaacg tgtggaaagc 669181 atcctcggac ccggcgcgga cgatatctgg atctccacat tccacagcat gtgcgtgcgg 669241 atcttgcgca gagatatcga ccggattggg atcaaccgaa atttctccat ccttgatacg 669301 gctgaccagc tttcagtgat caaggggatt ttgaaggagc gcaatcttga tccgaagaag 669361 tttgacccga gaagcatcct cggcacgatc agcagtgcaa aaaacgaatt gaccgaaccg 669421 gaggaattct ctaaagttgc tggcggctac tacgatcagg tggtcagcga tgtatatgct 669481 gattatcaga agaagctatt gaaaaaccag tcgctcgatt tcgacgattt aattatgacg 669541 acgattaaac tgtttgacag agtgcctgaa gtgcttgaat tttatcagcg caaattccag 669601 tacatccacg ttgatgagta tcaggatacg aacagggcac aatacatgct cgttaagcag 669661 cttgccgagc gtttccagaa cctttgcgtt gtgggggatt ctgatcagtc aatctacaga 669721 tggcgcggcg cggatatcac caacattctt tcatttgaaa aagattatcc gaatgcaagc 669781 gtgattttgc tagaacaaaa ctatcgttca acgaaacgga ttttgcgcgc ggctaacgag 669841 gtcattaaaa acaactctaa ccgcaaaccg aaaaatttgt ggacggaaaa tgatgaaggc 669901 atcaagattt cctattatcg cggtgataat gagttcggtg aaggacagtt tgtggccggc 669961 aaaattcatc agcttcacag cacaggcaag cggaagctgt cggatatcgc catattatac 670021 cggacaaacg cgcagtcccg tgtgattgag gaaacgcttc tcaaagcggg cttgaactat 670081 aacattgtcg gcggcacaaa gttctatgac agaaaagaaa ttaaagacat tcttgcgtac 670141 ctgcgcctcg tatccaatcc ggatgacgat atcagtttca cgcgcattgt caatgtgccg 670201 aagcgcggag tcggcgcgac atcacttgaa aaaatcgctt cgtatgcggc cataaacggc 670261 ttgtcctttt tccaagcgat tcagcaggtt gattttatcg gcgtcagtgc caaagcggca 670321 aacgcgcttg acagctttag acagatgatt gaaaacctga ccaatatgca ggattactta 670381 tccattacag agctgacaga agaaattctt gataagacgg aatacagaga aatgctgaag 670441 gctgagaaat cgatcgaagc ccaaagccgt ttagaaaata tcgacgagtt cctgtctgtt 670501 acgaaaaact ttgaacagaa aagtgaagac aagacactcg ttgcgttcct gacagacttg 670561 gcattgatcg cagatattga tcagctcgat cagaaggagg aagagtcagg cggcaaggat 670621 gcgatcaccc tgatgacact gcacgccgcg aaaggactgg agtttccggt tgttttcttg 670681 atggggcttg aagaaggcgt cttcccgcat agccgttcac tcatggagga agcggaaatg 670741 gaagaagaac gccgccttgc gtacgttggg attacaaggg cggaacagga gctttatctg 670801 accaatgcta aaatgcgcac cttgtttggc cggacaaata tgaacccgga atctcgcttc 670861 attgctgaaa taccggatga tttattggaa aacctaaatg agaaaaaaga aacaagagcg 670921 acgtctgcga gaaaaatgca gccgagacgc ggccctgttt cacgcccggt atcctacgcc 670981 agcaaaacag gcggcgacac cttgaactgg gcagtcggag ataaggcggg ccataaaaaa 671041 tggggaacag gaactgtcgt cagcgtgaaa ggcgaaggag aagggacaga gcttgatatt 671101 gccttcccga gccctgtcgg cgtgaaacgc ctgttagcag catttgctcc tattgaaaag 671161 cagtaattga agaggaaagg aagaagcaga tggacaaaga aacagcgaag cagcgggcag 671221 aagaactgcg ccgcaccatc aacaagtata gctatgaata ttacacctta gatgaaccga 671281 gcgtcccaga tgccgaatac gacagattga tgcaggagct gatcgcgatc gaggaggagc 671341 acccagacct cagaacgcct gactctccta cgcagcgcgt cggcggagcc gtgcttgaag 671401 cgtttcagaa agtcacccac ggcacaccga tgctcagtct gggcaacgcc tttaatgctg 671461 atgatcttcg tgatttcgac cgccgtgtgc gccagtccgt cggcgacgat gtggcgtata 671521 atgtggagct gaaaatagac ggtcttgctg tttctctccg ttatgaagac ggctattttg 671581 tcagaggggc cacaagaggt gacgggacga cgggagagga tatcacggag aatctgaaga 671641 cgatccgcaa tatccccctt aaaatgaacc gtgagctgtc gatcgaagtg cgcggcgagg 671701 cgtatatgcc gaagcgttcg tttgaagcac tcaatgagga acggattaaa aatgaggaag 671761 aaccgttcgc caatccgcga aatgccgcgg cgggatctct cagacagctc gatccgaaaa 671821 ttgcagcgaa acgaaacctc gatatcttcg tctacagtat agcggagctt gacgagatgg 671881 gtgtagagac gcaaagccaa gggcttgatt ttctcgacga actcggattt aaaacgaatc 671941 aggaacgaaa aaaatgcggc agcatagaag aagtcattac gctgatcgat gagcttcagg 672001 cgaagcgcgc ggacctgccg tacgaaatag acggcattgt cattaaagtc gattctctcg 672061 atcaacagga ggagctcggt tttacggcga aaagcccgcg ctgggccatc gcgtataagt 672121 ttcctgctga agaggtcgtg acgaagcttc tcgatatcga attaaatgtc ggcagaacgg 672181 gtgtgattac gccgactgcg attcttgagc cggtaaaagt tgccggcaca acggtctcaa 672241 gagcatccct tcataacgaa gatttaatta aagagaagga cattcggatt ttggataagg 672301 ttgtcgtcaa aaaagcgggc gatatcatcc cggaagttgt gaatgtcctc gttgaccagc 672361 gcacaggaga agaaaaggaa ttcagcatgc cgacggaatg tcctgaatgc ggcagtgaac 672421 tcgtccggat cgaaggagaa gtggcgcttc gctgcattaa ccctgaatgt ccggcgcaaa 672481 tccgggaagg gcttatccat ttcgtttccc ggaatgccat gaacattgat gggctcggcg 672541 aacgagtgat cacacagctg tttgaggaaa accttgtccg caatgtggca gatttatata 672601 agctgacgaa ggaacgagtc atccagctcg agcgcatggg cgaaaagtcc actgaaaacc 672661 tgatcagctc catccaaaaa tcaaaagaaa attcgttaga gcgcctgctg tttgggcttg 672721 gcatccgttt tatcggatca aaggccgcaa agacgcttgc catgcatttt gaaagcttgg 672781 agaacctgaa aaaagcctct aaagaggaac ttctcgcggt agatgaaatc ggtgaaaaaa 672841 tggctgatgc tgtgatcacc tattttcata aagaagaaat gcttgaactc ttgaatgaac 672901 ttcaggagct gggcgtaaac acgctctaca aaggcccgaa aaaagtaaaa gcagaggaca 672961 gcgactctta ctttgctggt aaaacaattg ttctgacagg aaagctggaa gagctgtcaa 673021 gaaacgaagc caaagcgcaa atcgaagcgc tgggcggaaa gctgactgga agcgtcagca 673081 aaaacacaga cttagtcatc gccggagaag cggcgggaag caagctgaca aaagcacaag 673141 agctgaacat tgaagtgtgg aatgaagaac agttaatggg agagctaaag aaataagagg 673201 agtgttttct attgaaaaag acgttggcat tggcggcaac ggcggcagta ttaatgctgt 673261 ctgcctgctc gtcaggtttc gggggggaga aggaggaaga gattacgcaa aagacggcga 673321 aatcgtcaga aaaagcgatt gtcccgaaat ataatatctc tgactcctat tacaaaatgg 673381 tgctgccgtt taaggcaggc aaagcgcgcg gcttaacaac ggaacagctg aatacaaggc 673441 tggacattga cgaatttgaa acagggctga tgcgccttgc ccaagattct ttctcaactg 673501 acgattatct gttccaagaa ggacaatatt tagatgagga tacagtatta agctggctgg 673561 cacggaaaaa aacgggctct gatttgaaaa aagccgaaaa agaagataag aacttcaaaa 673621 atgaaggctt gaacccggcg ctcccgagtt ctggttcaac agaagaaaag aacgaaagca 673681 gcccaattta tttagcatcc atgcttgagc acgattattt agtcagaaaa gacaagaatt 673741 ctatccagct tggcggcgtc atgatcggac tggcgttaaa ctcagtgtat tactatcgtg 673801 aaaaaactgg cgacccgcaa aaagaagtgg agattaaaga cagcacgctt cgccagcagg 673861 gagaaaaaat tgcacaggag gttattaacc gcctccgcaa aaaagataac ttgaagaatg 673921 tgccgattac cgtggcgctc tacaagcagg cgtcaaaaac atcgattgtg ccggggaact 673981 tcatcgccaa aacagaggtc aaagcaggct ctactgatat ctcaaattgg gatgacatca 674041 atgaaaaata tgtattctat ccggcggata caaccacagc agaaaagtac ccggatgaca 674101 ccgaggtctt taagcggttc aaaaactcaa ttgaagaata tttcccgaac tatacaggcg 674161 ttgtcggtac agcgctgtat gaaaatgatg aaatgaagaa aatgaagatt gacataccaa 674221 tgcaattcta cggaaaaagt gaagttgtcg cgtttaccca gttcttaacg ggtgaagtga 674281 tggactacta ctctaagagc tcagttgatg tcgaagtcaa tatcacgtcc tcagacggac 674341 aggaagcggt cattatccgc aatgccggag ataaagagcc gactgttcac atttatgact 674401 gatagaaaac ccttgtgcca tattggcaca agggttttta tgttacaatt aacaggaaaa 674461 gggaaaatat tttcacttct gccgaaacac aaatcaaggg gaggtatgtt gatgctggaa 674521 atcgtgtgaa aacaatcatt atcaaatcta tagcaatgaa aggatgttag acgtgcataa 674581 agatatcaaa aaaatatttc atgaagagca ggttttggca gaagctgcag cgagatacgg 674641 tttctcaaaa gatcaggtgc gttttctggc tgatgcggaa aactatgtat atgaatgtat 674701 gaaagacaat caaccttata ttttaaagat tacccatacg attcggagat cttctgatta 674761 tatgatggga gagatggaat ggctccgtca ccttgcaata gggggaattt cagtagccaa 674821 accgctcccg tcgctgaacg gaaaagacgt agaagcagtg ccggacggaa acggcgggtc 674881 atttttattg agagtgtatg agaaagcgcc ggggcaaaaa gtggatgaat cggactggaa 674941 tgaaacgcta ttttatgagc ttggcagata cacaggcagc atgcacagcc tgacaaaaag 675001 ctacaaattg agcaatcccg ctttcaaaag acaggaatgg gatgaagagg agcaattaaa 675061 gctgagaaaa tatgtgcctg aagatcagat aaaggtgttt cagcaagccg attctttgat 675121 gaatgaactg cggaggctcc cgaaaagcca ggacaactac ggcttggtgc atgcggatct 675181 gcaccatggc aattttaact gggatcatgg caaaatcacg gcatttgatt ttgatgatat 675241 cggctacaac tggtttgtta acgatattag cattcttctc tacaatgtcc tgtggtatcc 675301 tgttgtgcca tatgatgata aagctgcgtt tacagaagaa tttatgacgc attttatgaa 675361 agggtactgg gaggaaaatg agcttgaccc tgcatggctg atgataatac ctgatttcct 675421 ccgccttcgc catatgctga tttacggatt gctgcatcag atgtttgacc ttaacacaat 675481 aggagaagag gaaaaagaaa tgctggccgg tttcagaaga gatatagaga atggcacgcc 675541 gattacagca tttgattttt cagcactggt gtagatagaa aaagccaatg ggattccagt 675601 cccattggct tttataatgt atcacacttc acgccgacta cgccttcaat ggctttaatg 675661 tcatagtaga catcggtcgt gtatctgttt ttatggacgc ggaccttcac ttccataatt 675721 ggaaaatcct tttcgcctag gtcgtcgatc cgaacggagt gtgctttgat atctcttctt 675781 ttcatttctt ttaaaatctc tgtcattttg tctttatcag aaagtgacat tctgatgcgg 675841 atgtcttttt cctgcaggcg gtcggggccg atttttctga ccacccatgg gagaaattcc 675901 acactgatca ggatgaacag aagactggca aacgcttctt tataaaaacc ggctcccgta 675961 gcaagcccga gccccgctgc cccccagatc atggccgatg tcgtcaggcc ggaaatgaca 676021 tcattgcttt ttcgcaggat gacaccggcg ccgataaacc cgacgccgga gatgatttgt 676081 gccggcagac gaagcggatc catcatgatg cggtagtatt tagggaaatg atatgccgca 676141 ttaatactga cgatcgtcag catgcatgag ctgactgcga tgacaataca ggtttttaat 676201 ccgagcggct tattttttaa ttcgcgttca agcccgatga ccatgccaat caatgtggca 676261 atgcccaatt tcaataaaat atcaggatca atataccagc tcaacagcaa acttccccct 676321 tctctatggt gtttttaaat aaatatgatt ttctcacagt atttatagca aaacaagagc 676381 acaaaagcca ccaagctgcg cttgatggct tattgcttac tttttgcgtt ttaacagctt 676441 ttccatgaca ccgaataatc ggtaagaggc ttttgcagga cgttttgtga tcatgctgac 676501 aatgatgccg gcaatcatac tgagaataaa cccagggatg atttcgtaca caccggttga 676561 ttttgccagg ccggttgtaa tccagatcaa cacggtcgca gccccgacaa tcatggcagc 676621 aagcgcgccc cattcgttca ttcgtttcca atacagactg agcagaatcg caggcccgaa 676681 agctgaaccg aagccggccc aagcgtatcc gaccaaatca agaatggtgc tgttcgggtt 676741 caatgacaag agtaccgcga taacggcaat gactaagacg gacaatcgcc cgatcatgac 676801 caattcttta tcagaagctt ttcgtctgaa aaatgaccgg tataaatcct ctgttacagc 676861 acttgctgtg accaagagct gtgaggaaat cgaactcatg atggcagcca aaatagctga 676921 caataagaac cctgtaatta atgggtggaa caagatttta gagaagataa tgaaaatcat 676981 ctccggatct tttacagcaa ctccgaattt atgggcgtat gcaacaccga ttaaacccgt 677041 cagcacggaa cctagaactg taatgatcat ccagctcatg ccgattcggc gtgcaggttt 677101 taaatcttta atgtctttaa tggccataaa tcggacgatg atatgaggct ggccgtagta 677161 gcccaacccc caggctaaat aggaaataat gctaatgacg ctcgcgcctt taaaaatatc 677221 caataaatgt ggattaacag cgtcgatttc atggaaagtc ggagcaacgc cgcccacatg 677281 ggtaaaagca acgatcggca caagcactag tgctgcaaac atgatcgcac cctgcacgaa 677341 gtcagtcaga ctgacagcaa ggaaaccgcc aaacagtgtg tataacacga caactgcggt 677401 ggtcagaaac aggcctaatt tgtaatccgc accaaaagca gattcaaaca gccgtccgcc 677461 agataccata ccggaagagg tatacaatgt gaaaaagatc atgatgatca atgcagatac 677521 gattttcagc agtgatgaag aatgctggaa tcgtttatca aagaaatcag gaattgtaat 677581 cgcatcatct gccgcttctg tataagcacg cagccttgga gccagcagca agtaatttga 677641 gtacgccccg attgtaagac ctaaagcaag ccataaggtg gacagccctg tcgcaaacat 677701 cgcgccggga acacccatca gcatccatcc gctcatatcg gccgcgccgg cagacaaagc 677761 agtaacgaat ggtccgaggc ctcttcctcc aagcatgtaa tcattgatgt cagtggtttt 677821 cttgaatgca taccagccga ttaacagcat ggcaataaag taaattccta aagatataat 677881 aatttcaata ctcacgtttt accctctctt catttctaat aatgttgcat cacctctcaa 677941 attgatggtg ccagttaagc agcctggcgt aagtgcaaaa caaaagaaat tcttttgcgg 678001 gtgcacttgg taacttaacc taacaaagta ttcccggcca ttcaagcgat gaaacattga 678061 tcataagctg gaaataccgt tgcaaaccta gaagggaata aagaataaaa cgctttcaaa 678121 aaataattaa agtaaaaata ttcagaaaaa tatttcgttt ctccttctcc tcattttagt 678181 ataaaatata tagggtattg tttcgaaaac acaggcctgt ctcaaggcgt tttgttgctt 678241 taaagggctt gtttttgata tgatcagtat tatatgactt aacggagaaa tatgtggagg 678301 tggatcatat gtcacgaatt tcaatagaag aagtaaagca cgttgcgcac cttgcaagac 678361 ttgcgattac tgaagaagaa gcaaaaatgt tcactgaaca gctcgacagt atcatttcat 678421 ttgccgagga gcttaatgag gttaacacag acaatgtgga gcctacaact cacgtgctga 678481 aaatgaaaaa tgtcatgaga gaagatgaag cgggtaaagg tcttccggtt gaggatgtca 678541 tgaaaaatgc gcctgaccat aaagacggct atattcgtgt gccatcaatt ctggactaaa 678601 ggagggacac aagaatgtca ttatttgatc ataaaatcac agaattaaaa cagctcatac 678661 ataaaaaaga gattaagatt tctgatctgg ttgatgaatc ttataaacgc atccaagcgg 678721 ttgatgataa ggtacaagcc tttttggcat tagatgaaga aagagcgcgc gcatacgcga 678781 aggagcttga tgaggcggtt gacggccgtt ctgagcacgg tcttcttttc ggtatgccga 678841 tcggcgtaaa agataatatc gtaacaaaag ggctgcgcac aacatgctcc agcaaaattc 678901 tcgaaaactt tgatccgatt tacgatgcta ctgtcgttca gcgccttcaa gacgctgaag 678961 cggtcacaat cggaaaactg aacatggacg aattcgccat ggggtcatct acagaaaact 679021 cagcttacaa gctgacgaaa aacccttgga acctggatac agttcccggc ggttcaagcg 679081 gcggatctgc agctgcggtt gctgcgggag aagttccgtt ttctcttgga tctgacacag 679141 gcggctccat ccgtcagccg gcatctttct gcggcgttgt cggattaaaa cctacatacg 679201 gacgtgtatc tcgttacggc ctggtcgcat ttgcgtcttc attggaccaa atcggaccga 679261 ttacacgtac ggttgaggat aacgcgtttt tacttcaagc gatttccggc gtagacaaaa 679321 tggactctac gagtgcaaat gtggacgtgc ctgattttct ttcttcatta actggcgaca 679381 tcaaaggact gaaaatcgcc gttccgaaag aataccttgg tgaaggtgtc ggcaaagaag 679441 cgagagaatc tgtcttggca gcgctgaaag tccttgaagg tctcggcgct acatgggaag 679501 aagtgtctct tccgcacagt aaatacgcgc ttgcgacata ttacctgctg tcatcttctg 679561 aagcgtcagc gaaccttgca cgctttgacg gcatccgcta cggctaccgc acagacaacg 679621 cggataacct gatcgacctt tacaagcaaa cgcgcgctga aggtttcgga aatgaagtca 679681 aacgccgcat catgctcgga acgtttgctt taagctcagg ctactacgat gcgtactaca 679741 aaaaagcgca aaaagtgcgt acgttgatta agaaggattt cgaggacgta tttgaaaaat 679801 atgatgttat tgttggaccg actacaccga cacctgcgtt taaaatcggt gaaaacacga 679861 aggatccgct cacaatgtac gcaaacgata tcttaacgat tccggtcaac cttgccggcg 679921 taccgggaat cagtgtgcca tgcggattag cagacggact tccgctcggc ctgcaaatca 679981 tcggaaaaca ctttgatgaa agcactgtat accgcgttgc tcatgcattt gaacaagcaa 680041 cagaccatca taaagcaaaa cctgaactgt aaggggtgaa aagaattgaa ctttgaaacg 680101 gtaatcggac ttgaagtcca cgttgagtta aaaacaaaat caaaaatttt ctcaagctct 680161 ccaacgccat tcggcgcgga ggcgaatacg cagacaagcg ttattgacct cggatatccg 680221 ggcgtcctgc ctgttctgaa caaagaagcc gttgaattcg caatgaaagc cgctatggcg 680281 ctcaactgtg agatcgcaac ggatacgaag tttgaccgca aaaactattt ctatcctgac 680341 aacccgaaag cgtatcagat ttctcaattt gataagccaa tcggcgaaaa cggctggatc 680401 gaaattgaag tcggcggcaa aacaaaacgc atcggcatca cgcgccttca tcttgaagag 680461 gatgccggaa aactgacgca tacgggcgac ggctattctc ttgttgactt caaccgtcaa 680521 ggaacgccgc ttgttgagat cgtatcagag ccggacatcc gcacgccgga agaagcgtac 680581 gcatatcttg aaaagctgaa atccatcatc caatatacag gcgtttctga ctgtaaaatg 680641 gaagaaggct cacttcgctg tgacgccaat atctctcttc gtccgatcgg ccaagaggaa 680701 ttcggcacaa aaacagaatt gaaaaacttg aactcctttg cgtttgttca aaaaggcctt 680761 gagcatgaag aaaaacgcca ggagcaggtt cttctttccg gcggcgtcat ccagcaagaa 680821 actcgccgtt atgatgaagc aacgaagaaa accattctta tgcgtgtcaa agagggatct 680881 gacgactacc gttacttccc agagccagat ctagtcgagc tctacattga tgatgaatgg 680941 aaggaacgcg taaaagcaag cattcctgag cttccggatg agcgccgcaa gcgttatatc 681001 gaagagcttg gcttgcctgc atatgacgca atggttctga cgctgacaaa agaaatggct 681061 gatttcttcg aagaaaccgt tcaaaaaggc gctgaagcta aacaagcgtc taactggctg 681121 atgggtgaag tgtcagctta cctaaacgca gaacaaaaag agcttgccga tgttgccctg 681181 acacctgaag gccttgccgg catgatcaaa ttgattgaaa aaggaaccat ttcttctaag 681241 atcgcgaaga aagtgtttaa agaattgatt gaaaaaggcg gcgacgctga gaagattgtg 681301 aaagagaaag gccttgttca gatttctgac gaaggcgtgc ttctgaagct tgtcactgag 681361 gcgcttgaca acaatcctca atcaatcgaa gactttaaaa acggaaaaga ccgcgcgatc 681421 ggcttcctag tcggacagat tatgaaagcg tccaaaggac aagccaaccc gccgatggtc 681481 aacaaaattc tgcttgaaga aattaaaaaa cgctaataaa aaagcagccc ttagaggctg 681541 ctttttttat ggtcaaattg agataaagac aagatgaggg cccgaagcct ttcaacttct 681601 ttgtcgttgg ttccggccaa attggacagc atgcctttaa taatcggctt gcgcggttta 681661 tcctgagtca attcttcctc gataacatca agtgacacgg tgatatcctc gggcagcgtg 681721 ctgttttctt tcactttctg aatgtcctca agcagctggt cttttcccgc aggcatcggg 681781 ttaaaaatgt cttttgatac aatcggattg agtgcagaac ggctcagccc ctgtacaaga 681841 tcatccagtc tctcaataat aaaggctgag atttcttctg catcgatatt aagctcaccg 681901 ttaaatacca tcacgttcat ataggaatgc acaatgcctc ttgccatgat ggacagatct 681961 gcgacatacc gctcgattcc ttcgccatag gataccagca aggcgttccg gtacagctta 682021 tccgtctcca tggttacttt gtaaaagtat tgcttgattt cttgattttc cggaatgata 682081 ttttcggtaa gcaaaagaac gataaaatct ttatgatcgc gaaaatcctc aaattgagcg 682141 ccaatttgct tttttaacac ttccttaggc ggctttccgg cgagatcttc ttctatattt 682201 ttcattttgt tcatagacat accgatataa tattcacagg cagataacag cagcgcttct 682261 ttcgatttga agtgcaaata aaaagcgccc ttcgaaatgc cgcattcact ggcgatttct 682321 tggatcgtcg tagctgcgaa tccttttttc gcaaataaac gaatgctggt ttttatgatt 682381 ctctcttttt tttcattcat gacgtgcttc cccttaatcc ttgaaaaatt tagtaaaatt 682441 ttctggtata tgagttgacg ttgttgcgtt ataacgttta gtattatata gaatgaccag 682501 tcagtcaata aaaaatgtaa tggaggatat gatgaaccac gttattaatt tcgttctgaa 682561 aaacaaattc gccgtatggc tgatgacgat tattgtaacg gcagccggct tgtatgcggg 682621 tatgaatatg aagcaagagt ctattcctga cgtgaacatg ccttacttga cgatcagcac 682681 gacatatccg ggtgcaacac caagccaagt ggctgatgaa gtgaccaaac cggttgaaca 682741 agccgtacag aacttggacg gtgtcagcgt tgtgacgtcg acgtcctatg aaaacgcatc 682801 gtcggtcatg attgaatatg attatgagaa agatatggac aaagcgaaaa cagaagcagc 682861 tgaagcgtta gaaaacgtca acctgcctga tgacgcgaag gatccggaga tttcacgcta 682921 cagcttgaac tcattcccga ttctgacgct gagcgtgtcc agtgataaag ataatctgca 682981 agagctgacg aaacaagtgg aggacagcct cgtttctaag cttgaaggca tagaaggcgt 683041 tgcgtccgtc caagtatcag gccagcaggt ggaagaggtt gaattctctt tcaaagaaga 683101 caaactgaag gaatacggcc ttgatgaaga tacagtcaag caagtgattc aaggttcaga 683161 tgtgacaact ccgcttggat tgtacacatt cggaaatgaa gaaaaatctg tcgtcgtcag 683221 cggcgatatt gaaacaatta aagatttgaa gaatatgaga atcccgacgg catctgcttc 683281 aagtgcaggc agcagcgcag catctcaagc aggtgcgcag agtgctcaag cagcccaaag 683341 cgcgcaagcg gcagcacagg tgcagcaaag cgcaagcaca gcagtgccga cggtcaagct 683401 ttctgacatt gctacaatta aagatgtgaa aaaagctgaa tccgtttcac gcacaaatgg 683461 caaagacagc atcggcatca acatcgtcaa agcaaacgat gcgaatacgg tagaggttgc 683521 cgacgatgtc aaagctgagc tgaaaaagtt caaagaagac cataaaggct tcaattacag 683581 cgcaactctc gacatggcgg agccgatcac acagtcagtt gacacgatgt taagcaaagc 683641 catcttcggt gctatttttg cgattgtgat tattctctta ttcttaagag atatcaaatc 683701 aacattaatt tctgttgttt caattccatt atcattgctg atcgcactcc ttgtgctgca 683761 gcagcttgat atcacattga atattatgac gctcggcgca atgaccgttg ccatcggacg 683821 tgtagtcgat gactccatcg ttgtgatcga gaacatttac cgccgcatga gactcaaaga 683881 tgagccgctc cgcggaaaag ccttggttcg tgaagcgacg aaggaaatgt ttaaaccgat 683941 catgtcatca acgattgtga caatcgcggt attcctgccg ctcgcacttg taggcggaca 684001 aatcggtgaa ttgtttattc catttgcctt aacgattgtt tttgcgcttg ccgcatccct 684061 agtgatttca atcacgcttg tgccgatgct cgcacacagc ctgttcaaaa aatcattaac 684121 cggtgcgccg attaaagcga aagaacacaa acctggcaga cttgcaaaca tctataaaaa 684181 agtattgaac tgggcgctga gccacaaatg gatcacgtct atcatcgcgg ttctgatgct 684241 ccttggaagc ttgttcctcg taccgttaat cggtgccagc tacctgccgt ccgaggaaga 684301 aaaaacgatg cagctcacat acagcccaga accgggtgaa acgaaaaaag aagccgaaaa 684361 tgaagctgaa aaagcggaaa aaatcctgct tgaccgcaag catgtcgata cggttcagta 684421 ttcattaggc tctggcagcc cgcttgccgg aggagattct aacggtgcgt tattctatat 684481 caaatatgaa agcgacacac ctgactttga taaagaaaaa gataacgttc tgaaggaaat 684541 ccaaaagcaa tctgaccgcg gagaatggaa gtcacaggac ttcagctctt caggcaataa 684601 taacgaatta acatactatg tgtatggcga ttctgaaaac gatattaaag acacggtcaa 684661 agacattgaa aaaatcatga aagatgaaaa ggatctgaaa aacgtaaatt caggcctttc 684721 cagcacatat gatgagtaca catttgtcgc tgaccaagaa aaactaagca agctcggttt 684781 aaccgcgtct caaatttctc aggccttaat gtcacaaaca tcgcaagaac cgctcaccac 684841 tgtgaaaaaa gacggcaaag agcttgatgt gaacattaag acagaaaaag acgagtataa 684901 gagtgtgaaa gatttagaga ataaaaagat cacttccgcg actggccagg aagtcaaaat 684961 cggcgatgtg gcaaaagtga aagaaggatc aacatcagat accgtgtcaa aacgtgacgg 685021 aaaagtctat gcagatgtca caggtgaggt tacctctgac aacgtcacag ccgtatcagc 685081 tgctatccag aagaaaatcg ataagcttga ccaccctgat aacgtatcga ttgacacagg 685141 cggcgtatca gcggatatcg ctgattcctt cacgaagctc ggtttagcga tgctggcagc 685201 aatagcgatc gtttaccttg tgctcgtgat taccttcggc ggagcactag cgccatttgc 685261 gattctgttc tcattgccgt tcacagtcat cggtgccctg gtcggacttt acgtatcagg 685321 tgaaacgatc agtctgaacg ccatgatcgg tatgctcatg ctgatcggta tcgttgtcac 685381 gaatgccatt gtcttaattg accgcgtgat tcataaggaa gcggaaggcc tgtctacgag 685441 agaagcgctc ctggaagccg gctctacacg actccgtccg atcctgatga cagccattgc 685501 gacaatcggc gccttgattc cattagccct cggcttcgaa ggcggaagcc aggtcatttc 685561 aaaaggactc ggcgtaacgg ttatcggcgg tttaatcagt tcaacgcttc tgacgctcct 685621 gatcgtgcca atcgtatatg aagtattggc gaagttccgc aagaaaaaac cgggaacgga 685681 agaagagtaa aaaacaaaaa gcctcagctc tgctgaggct ttcagcttgt tgaaaaaccc 685741 tcgcattcgt tgtcaggtct gcgcgtcggt gctcacgaat tctacattcg ctccgctcca 685801 atgctccccc ttcctagact acaagggttt tcaatcaagc tgaaagaatg ttaaggatga 685861 caaaagctca aaacaagaat cagttttgag cttttgtgcg ttttcacctg taagattatg 685921 tacattttgt tgcgattttt ttaactcata gtataattaa aggttgttag tgtaaaaatg 685981 gatcggatac tcttaagtag gatgatgaga taatgaaacg tgcacgcata atatacaatc 686041 cgacttcagg acgggagatc tttaaaaagc atcttgccca ggtcctgcaa aaatttgaac 686101 aagccggcta tgaaacctcc acccatgcga cgacatgcgc aggagacgct acacacgctg 686161 ccaaggaagc ggcattgcgt gagtttgacc tgatcattgc ggcaggcgga gacggaacga 686221 tcaacgaggt cgtcaacggg cttgcgcctt tagacaatcg tccgacactc ggtgtgattc 686281 ctgtcggcac aacgaacgac ttcgccagag cgctcggaat cccacgcgag gatattttaa 686341 aagcggcaga tacggtcatt aacggcgttg cccgcccgat tgatatcgga caggtcaacg 686401 gccagtattt tatcaatatc gccggcggag gccgtctgac ggagctgacg tacgacgtgc 686461 caagcaaact gaaaacaatg ctcggccagc ttgcttatta tttaaaagga atggaaatgc 686521 tgccttcact tcgtccgaca gaagtcgaga ttgaatatga cggcaagctg tttcaaggtg 686581 aaatcatgct gtttttggtc acgctgacaa actccgtcgg cgggttcgaa aagctcgcgc 686641 cggattccag cctgaatgac ggcatgtttg atttgatgat actaaagaaa gcaaaccttg 686701 ctgaatttat cagggtcgcc acgatggcgc ttcgcggaga acacatcaac gaccagcaca 686761 ttatttatac aaaagcgaac cgcgtgaaag tcaatgtatc agaaaagatg cagctgaacc 686821 tggacggcga gtacggcggc atgctgccgg gcgaattcgt gaatctgtac cggcacattc 686881 acgtcgtcat gccgaaggag aaagcggaac agttggatga ctaaaacttg gcttggtaag 686941 ccaagctcag aatgttgaca aaatcctaaa acagttttcg ttttaggatt ttgtcatctt 687001 ttcagcgtga ttgaaaacct ttgaagtcta ggaagggcga gcatcggagc acagcgaatg 687061 ttgaattcgt gagcaccgaa gcacaggcct gacaacgaat gcgaaggttt gcctacacgc 687121 tgaaacttgg cttgaatagg ccaagttttt ctttcgctta aaactagagg tgattataga 687181 tgaaaatgaa acccccagta gaaaaaaatg aatactacga tgtgacattt gaggatttga 687241 cacatgaagg agcgggcgtc gcaaaggtcc aaggcttccc gatctttgtg ccgaatgccc 687301 tacccgagga aaaagcccaa atcaaagtga cacgcgtcaa aaaagggttc gccttcggcc 687361 gcctgattga gctgaaggaa gaaagcccgc atagaacgga cgccccatgc ccgatttaca 687421 aacaatgcgg aggctgccag cttcagcaca tgacctacga aggccagctc ctgtttaaac 687481 agaaacaagt caaagacgtc ttagaacgca tcggcaagct ggacctttca aaagtcaccg 687541 tgcacccgac actcggcatg gaagacccgt ggaactacag aaacaaagca caggtgccgg 687601 taggagaacg ggaaggcgga ctcgtcgcgg gattctatca gcaaagaagc catgacatca 687661 tcgacatgag cgcctgcctg atccagcaat ccaaaaacga cgaagccgtt caagctgtca 687721 aagacatttg cgcaaactac ggtgtcaaag cctacaacga agaacgccac aaaggctggc 687781 tccgccacat catggtcaga tacggcgttg ttacgggcga aatgatgatc gtcttcatca 687841 caagaacaag cgacttcccg cacaaagcga agatcatcga agacatcaca gcgcaattcc 687901 cgcacgtcaa atccatcgtg caaaacatca acccaaacaa aacaaacgtc atttttggca 687961 acgaaacaaa cgtcatctgg ggcgaagaat acatctacga cctcatcgga gacgtcaaat 688021 tcgccatctc cgccagatcg ttttatcagg tcaacccaga gcaaacaaaa gtgctctacg 688081 acaaagcgct tgagtacgct gagcttcaag gggaagaaac cgtcatcgac gcttactgcg 688141 gcatcggaac gatttctctc ttcctggcaa agcaggcgaa aaaagtgtac ggtgtagaga 688201 ttgtgccgga agcaattgag gacgcgaagc gaaacgccga attaaacggc aacacaaacg 688261 cagagtttgc tgttggagaa gcggaaaccg tgattccaaa gtggtacgaa gaaggcatta 688321 cagctgatac gctggtcgtc gacccgccaa gaaaaggctg cgacgaagcc ctcctgcgga 688381 caattgtgga gatgaagccg aagcgggtag tgtatgtgtc ctgtaatcct ggcacgcttg 688441 cgagagattt gcgggtgctt gaggatggcg ggtacgtgac gcgcgaagtg cagcctgtgg 688501 atatgtttcc gcatacgaat catgtggagt gctgtgtgtt gataaaatta aaagaataaa 688561 tagtcaaaaa tctatgctga tggaactgtt ggttctctaa aacgataatt gatttcaatg 688621 gttccatttg catgtacttc tatttcatct actaacaaat gaagcatttc gggggtaagt 688681 gtaccttcct tcatgaattt atctaagctc tttttaaaat caattatttc tttttcaatc 688741 ttttgaaatt ctaggtcctt agatagttgg tgaagggtag tttcaaaatt tgaaatatct 688801 tcattggtga tatttatggc taattggtaa tcttctttag atataacacc attagcaaga 688861 gagataacta aattggattt atctctcttt ttatcgttta atttttcatt aatttcgatt 688921 atcttagatt cgattttttc tttgtacttt aacgcttttt cacttaattc tttaaaataa 688981 ttttccttac tgaatttcaa atatatctta tttaggttgg ttattacttt atcagttaaa 689041 tctatttcac ttacgtaatg atcactacat gcttttaaac catgtttatt ataacttcca 689101 caaacataac cttttcgatt ctttttaaaa tgcattgacc tcctgcaatc tttgcaaacc 689161 gcagtatttg taaagagatg tacttcagct tgaggtctcc ttctttttct agttattaaa 689221 atctcttgta caataagaaa gtcttctaaa ggtatgattg gttcgtggct tttttcaata 689281 attatttggt tttctaggtt aactgacctt cttcttttac tggtaacact cggtctatat 689341 tctctacatt gttgtagtgt cccagtatag tgaggatttt cgagaatttt tcttattgaa 689401 gatccgtgcc atttgtcagt agcgttcttt ttgcgggcaa gctgcgaggg actagtgacc 689461 ccttcgttat acaatcccct tgctattgca tcaaagcctt ttccagcaat atattctgaa 689521 aagattctaa tatttactat tttctctgcg tttgctgaat ttgagagaga tatgattgta 689581 gaacgaactc aagaaggtaa aatgttggcc aagcagaatc cggatttccg agaaggaaga 689641 cccaaaaagt tcacaaagca gcaaatcaat catgcattaa cattactaga aaatcattcg 689701 tataaacaag ttgaagatat gactgggata tcagtttcta cacttgtaag agctaaaaag 689761 aagaaagctg ctgaagctat aaatggataa atattgtgaa ttaattattc aatatcttga 689821 gaaattttta taaaagtaat caaaagttta atgggggaaa cgaaatggcg ctcattgatt 689881 tagaagataa aattgctgaa atagtgaatc gagaagatca ttcagatttc ttgtatgaat 689941 tactcggtgt atatgatgtt ccacgagcta caattacgcg cttgaaaaaa ggaaatcaaa 690001 accttacaaa acgggttggt gaagtacact taaagaataa ggtgtggttt aaggaggcta 690061 agaaaggaaa gctctttgac gcccttattg atatagaaca acaagttgaa tatctttcag 690121 ctaagccacg atatttatta gttactgact atgatggagt attagcgaaa gatacaaaaa 690181 cattagaggc tcttgatgtt aaatttgaag aacttcctca gtatttcgat ttcttccttg 690241 cttggaaagg tattgagaaa gtagagtttg aaaaggaaaa ccccgctgat attaaagcag 690301 ccgaacgttt tgcacggata tatgatgtac ttcgtaaaga aaacaatatt attgagacta 690361 atagagggtt agatttattt cttattcgtt tactgttttg ttttttcgca gaagatactg 690421 acatcttcaa acgaaatagt tttacgaatt taattaagac tttgactgaa gaagatggtt 690481 caaatctaaa taaattattt gctgatttat ttatcgtgtt agataaaaat gaacgagacg 690541 atgttccatc ttatttaaaa gagtttccgt atgtaaatgg ccagttgttt actgaaccac 690601 atacagagtt ggaattttct gccaaatcca gaaagttaat tattgagtgc ggtgaattat 690661 taaactgggc taaaatcaat cctgatatct ttggttcaat gattcaagct gttgcttctg 690721 aagaaagccg tagttattta ggtatgcact acacaagtgt ccccaatata atgaaggtta 690781 ttaaaccgct tttcctagat aaacttaatc agtctttttt agatgcatac gatgattata 690841 caaaacttga aaatcttcta acacgaatcg gcaaaattaa attctttgat cctgcatgtg 690901 gttcagggaa ctttttgatt attacctaca aagaattacg gcgtatggaa atcaatatta 690961 taaaacgact tcaagaactc ttgggagagt atctttatgt accttcagta actttatctc 691021 aattttacgg aatagagatt gaagattttg cacatgacgt tgcaaaatta tcactttgga 691081 ttgctgaaca tcaaatgaat gaagaattaa aaaatgaagt tcataatgca gtacgcccaa 691141 cgttaccact tcatacagca ggggatattc gttgtgcaaa tgctattagg gttgagtgga 691201 ctgaggtttg tcccgcacaa ggatctgaag aagtatatgt ttttggtaat ccaccgtatc 691261 ttggttcaaa aaaacaaaac aaagaacata aatctgatat gttatcaatt tttggaaaag 691321 tcaagaatgg taaaatgctt gattatattt ctgcttggtt ttactttggt gctaaatacg 691381 cttcaactac aaatgcaaaa gttgcctttg tatcaacaaa ttcagttact caaggggaac 691441 aggtttctat cttatggaat gagttattca agtttggaat tcaaatcaat tttgcctata 691501 aatcttttaa atgggcgaat aatgctaaaa ataatgctgc ggtaattgtt gtgattgtag 691561 gttttggccc gttagatacc aaagtaaaca agtatttatt tgttgatgaa acgaaaaagc 691621 tagtttctaa cattagtccc tatttaactg atggtgaaaa tattcttgtt tcttctagga 691681 cgaagccaat ttcagactta cccaaactgc attttgggaa catgcctaat gatggcggag 691741 gattactctt taccattacg gaatatacag acgcaatcaa taagtatcct gaattagttc 691801 cctattttaa aaagtttata ggttcagtag agtttattaa tggtggttta cggtattgtt 691861 tatggcttaa tgaagcaaaa tatgaaaaaa taaagtctaa tcctctaata caagaaagaa 691921 tctcaatttc aaaaaatcac agggaaaaat caacagataa aggaacgaat aaacttgcat 691981 taactccgtg gaagtttaga gatactcatg aaacaactaa ttattccatt gttgttccat 692041 ctgtgtcttc tgaaaataga ttttatattc caatgggatt agcaggtgca gatacaattt 692101 tgtcaaatct aatttatgta atttacgatg cagaaattta ccttctaggc attttgatgt 692161 cacggatgca tatgacttgg gtaaaagctg tagccggaag attaaaaact gactataggt 692221 actctgcagg tttatgttat aacactttcc ctattcctga attatcaaca agaaggaaga 692281 atgaaattga agaagcaatt cttgaaattc ttgatcttcg tgaagagcag ggtggtacat 692341 tagcagagct ttataaccct tcaacaatgc caattgaatt aaaagtagca catgaaaagt 692401 tggatggaat tgtagaaaga gcgtatcgtc aaaaacaatt tgaatctgat gaagaacgct 692461 tagaagtatt gcttaaattg tatcaagaaa tgacagaacg gtaggtgtaa ggtgtatgga 692521 aaatataatt gaaattaatt ataaccaaac tggtaaaagt aagaaaacaa atgaatacgg 692581 tatgcgtgaa atgcaggcaa gagcttttga aaaacgtaac tcacaatatc tcttagttaa 692641 agcaccgcca gcttctggga aatctagagc tttaatgttt atcggtttgg ataagctcat 692701 aaatcaaggt ttgaggaaag tgattgttgc tgtacctgaa cgctctatag gttcttcatt 692761 taaaaatacg gatttaaaaa gttatggttt ctttgaaaat tggaaagttg atcctagaaa 692821 taatttaact gttggcggag ataactctaa ggttaaatct tttgttcgtt ttatggaatc 692881 ggacgatcag gtgttaatat gtacgcactc tactttgcga tttgcgtttg aaaaaattga 692941 tgataaagca tttgataatt gtttacttgc aatagatgaa tttcaccatg tatcggcaga 693001 tgtcaattct cgattaggtg aattgttaag aagtattatt cataattcat cagcacatat 693061 tgtagcgatg actgggtcgt atttccgtgg agattctgta ccaattttat taccagaaga 693121 tgaggaatta tttgacaagg taacttattc ctattatgaa caacttgatg gatatgaata 693181 tctaaaggga tttggtatag gatatcactt ctatcaaggc cagtacacat cagctattaa 693241 tgaagtattg gatacaaata agaaaacaat cgttcatatt ccaaatgtaa actcagggga 693301 atcgacaaag gataagtacg atgaagttgg taagatactt gatatgattg gtgaagttga 693361 atatcaagat gatgatactg gaattattta tgttaagcga cattctgacg gtaaaacatt 693421 gaaaattgca gatttagtag atgaccaagt tggaagagaa aatgtcgttg cgtatttgcg 693481 taatattgaa gccctagacg atttagatat aattattgct cttggtatgg cgaaagaggg 693541 ctttgactgg ccgttttgtg aacatacttt gacagttggt tatcgtggct cacttacaga 693601 aatagtacaa ataattgggc gctgtacacg tgatagttac aataaaacct atgctcaatt 693661 taccaaccta atcgcaatgc ctgatgcaaa ggatgaagta gtgacttata cagtgaatac 693721 aatgcttaaa gctatttctg cctcactttt gatggagcag gtccttacac ctgactttaa 693781 atttaaacgt agaagaaatg aaagtgaaaa atcttctact acaggagaat tattcgttaa 693841 gggattgaaa gaaccatcaa cagaaaatgt caaaaagatt attgaaaatg atattaatga 693901 tttaaaagca aaaatcatgc aagattcaca agtccaaaaa acatttagtg gagaagtaga 693961 tcccaaagta ttgaacaaag tgttgattcc gaaagttatt caaaaagtat atccaaattt 694021 atcagatgag gaaattgagg aagttagaca gcacgttgtt ctagatacag ttatgaaagg 694081 tgctaagtct gaagttgtag gaagtaaaga atttataaga atggcagata agtttataaa 694141 cattgaggat ttagatatca atctgattga ttccatcaat ccgttccaaa aagcatttga 694201 ggttctatcg aaagaattga actcaccagt gctaaaactg attcaggaaa ctattgatgc 694261 aaaacgtatt aattttgatg aagatgaact agtattcata tggccaaagg tttaggaatt 694321 ttatcgttca actggtagaa gacctgattc aaaatctgaa gacccacttg aaaggcgtat 694381 gggtgaagct gtattataca tgcaagagct taggaggaaa cgtgaaaatg gcaagtaata 694441 gataccattc tattaatgaa atcatggaaa gtcagctgtt ttaccaaatc acaacaccac 694501 ctaagaaaac acaaaaagcc cagtatgatc ctgaagttga aaagtttttg gagattattg 694561 aattcgtcaa agaaaatggg cgagaacccc aaaaagtccc tactgattta actgaaagaa 694621 gtttagcaag tcgattaatt gggattcgga aagatcctga tcgtatggaa tatttgaaag 694681 agtatgatga aattggatta cttgaagtaa gatcgaagga actaacaatt cctaaaattt 694741 cttcaattga tgatattcta aaaagtggct tatctgcatt attaggtgat aatttaaata 694801 atgatataac taggtcaatt tttgatacaa gttcacttca aaaggttacg acaatgcctg 694861 aatacgttgc aaagcgtaaa aaaataaaag attttggaaa gtttgaagag ctattcaaga 694921 agtgccacaa ggaaattaca gagggtaaac gaaaaatttt aactttcaaa aatgaacaag 694981 acatacagtc aaatagtttt tatatattaa aaggagttct tctttatgtt gaagatgtgg 695041 gagaacgtaa aaaagcaaag ggaaaaacca atgctagact tcgatgtata tttgaaaatg 695101 gaacggaatc agatatgtta ctacgttcct tatcagcgga gttatataaa catggtagac 695161 gtgtgaccga caatgaagat acattgttgg ataatgttag agaagatgat gtttcgactg 695221 gctttattta cgtactaaaa tctttgagta cagatccgca aattagttcc attaagaatt 695281 tatataagat cggttttaca actggttcag tagaaaatag aatcaggaat gcagaaaatc 695341 aatcaactta tctttatgct ccagtagaaa ttgtaaccac atatcaagtg ttcaatatga 695401 atgctagcaa atttgagacg gcaatccatc atgcgctagc aaataataat ttggatgttt 695461 ctattttggg ggcaaatgga aagatgttag ttcctaaaga gtggttcgtt gtcacacttg 695521 aagatttaca agctgtaata gatgagattg tgatgatggt tcatctttat gactaaatta 695581 gtatattagg attttagtat taataataat tttatagtag actatgaaaa aatttgatgc 695641 cataacaata acttgttccg ctttggagtt tgtcacaatt gtagaattat gtgttgcgag 695701 tattaatagg aaggggttga gcgaccgcaa aaaaaatttt cggtgctgtc cgcaaaaggg 695761 agtttgggtg ttttgcgtta tatttggttg tgtgaaggtt agcggaaact caattcgtga 695821 agttaggatt gcggttatta cgactgagta gtttcgtcat actcttttag cagtttttct 695881 gtcttatgca tttctttgag catcggattc atgtagtcgt tagctgattc tagatatgct 695941 ctcgtcagag tgtctagttt atttctaact ttagagaggt cttcttcgaa ttttccatcc 696001 gatgattgaa ggataaattc ttttgcctct tcatatcttt ttaatatgtt tttcaccatt 696061 ggagttggat tcttttgatt tattgttttt attacagtga ttgttaaatt tatttgtttt 696121 attaattctt ttcttactgt caaggtgatg ctccttttaa atctctattc tatttgagag 696181 ttgctatatc tgtttaatgg tttgatagac tactcatctt tataatttag agcaattttt 696241 acaacttgtt ccgctgtgta atcttcattg ctccagaaaa ttaaatcact tggtgccgga 696301 taaggaacat ttttctctaa taaatcgaga tattcactga ctttctcatc atctaatgtt 696361 gggttcatta attcctttac aagaaagatc aactcttctt ttgtcagttt atccattgtt 696421 tgccctccaa tagattgtat ctccattgat tttacaaatg actttatttc ttctgataat 696481 gttataggtt gtttgcataa tgatagataa ttgtcttgag aaaagttagt ctcattatag 696541 agtttattaa ttgtatttat aacaatatat tcatatggaa aacctctaaa atatctttat 696601 tttagattgg tttataaaaa atagctcagc agagtagggc tgagccattt tttaattata 696661 gaccgaggta actaattaca aattctttat catcctcatc ttcaggcaaa ataccaaggt 696721 ttttatattc ccatattgcg attctttcat atccatctaa ttctgaggct aaaatatcat 696781 cataattata atctaattgg aattctccgc tacgatccaa tgttagtgta aggttagtcc 696841 aaacatcatc gttattattt ctgtgttcag ttcttaattc ttcaaaaagt tctcttagtt 696901 ctcttaacaa cgtcttgaaa atatccttgc ttacgttgta atggctaggt atatcttgtg 696961 aataaataat ttgattattt tctggtgttc tgaaatgaaa aagaaccatt gtggaatcat 697021 ctaatacttc tgcataaaga tatatctttg tccattcacc aggtatgatg tcattgagtt 697081 tttctccaat aagttgatac aaatcttgca tcttcctagt ttccattctt ctaaccccca 697141 ggctgatttt taatagagac gcttatttct tttctgctcc caattttgta ggttacatcg 697201 aaatatgatg gtctaagtga atccccagaa tagactggtt ctatttgaac tgctactttt 697261 ttaggtggtt ttttgcttag ggcttttgcc cactcctgct ccatctcata ccatttccca 697321 ccgctcctat taatctgaga attcatcggc acgatattgt caaactggcc tgagcctttg 697381 aattgggtgg cgattaaatg gccgccgtca tcgtcaggct ttcggtcctg gggctttcca 697441 gcattcgttt gtgcatattg gtttcgtttc gcttctccca gctgcaagtc tgctttgaca 697501 cttgtaattc taccatagtt gtcagtcgtg tacgtgtagc cttcttttgt tttgtagatg 697561 atattaggct tcagcacttt ctttctgctc catcttgcga aatgctcgcc gtatttgacg 697621 gttaccggcg gtacatgtgg cgctggagtt cgtcttccgc ttgatgacgt tccgtatggt 697681 ttcggcagga tgaccttggc gaatttttgc agtccttctt taagcgtgac cccgttgact 697741 gcgttgtaag gaacgcctgc cggcactaaa tcatgacggg gatgatacgg gagaatatcc 697801 gcaagtgtga gatctccgat ttgatttaac ttggttttga cgtgtttttt tgatacttca 697861 atgcctgtgt ttactttttg tttgatgtga tcaacggttt gttttgagac tgttatggct 697921 ttttgggctg ttgctgattt gcttgctgct gttttgactt tggtcgtcac tttggcggct 697981 gtgccagttt ttgagacggc tcctacgcct tttgtgccga caattgatgt gacaacagtg 698041 ccaaccgcat atgacaccca tcttgctctt gagtaggtgt caccattcac catgtctttt 698101 tgatacgatt cttcgattgc cgctgaaatg gcttcatacg ttttgatcgg gtgagccatc 698161 gctccggtaa tcgcttcaac ggttcctccc ggatctgtga ccatatccca caggcctacg 698221 accgcgtctt tcccggaatc ataaaggccg acggcaaccc ctttgaagcc tgcttcaagc 698281 tcacgcgtgt tttcaatttg ggtgaagtat ctctgttgtt cagctgtcag attttcatag 698341 ccgatcgttt ttgccatttc gtagaattca tcggcatctg cataatcgta gtttttcagt 698401 ctttctttca gtttctcaat ctcgcgttcc ttcgcttcct ctttcttaat cttcaagtaa 698461 gcctcagtcc gcttttcaat gtcgcctttt ttcttatgta tgtcactctc acggtacgcc 698521 ttggcgttgt agtggatggg tgtggcgttt ttgcctttac ccgttgcttc ttggagcttt 698581 tggaagtcgg atttgatgaa ttgttcgttt ggttcagaca gggcgtattc tgttttcagg 698641 tcttcgtcca aggcgtccaa tttttccagt gtttttttgc gtttgtcgtt ggcatcggcc 698701 agctcgtctt tgaaggtttc tgttgaaaac aggtcgagcg ggaggatgtc gtcgatatcg 698761 tttaggatgt ctttcatcgc ttttttctgt tcggacatga tggatttaga ttttttattg 698821 gcatttgcca gttcgtgctc caggaaggat tcttcgatgt atgcgtctga gaggcctttg 698881 tcttcggcgg ctccggcgat gctgttgaaa aatgcgattt tcatgtcgat gtagtcgatc 698941 cactggtcgg cgacgccgac gtggtcgtga tagaatgcct tgatgttgct ggcgcctttt 699001 cctgagaatt cactgtcact gagatcagcg actcctttta acgcttttct caagttgacc 699061 atttgcgttc ttagttcttt gtactctttt gcacggtctg tcgcttccga aagcagtgtt 699121 ttcgcttcaa atactttcat gaccatttcc cttcttttgt tcgctcaata tcaaaatttt 699181 accacgggtc gggataaggt gggggtgaga acgtgttttg gtggaaaaat gagtcatttg 699241 gcatgtgtct ttattcgtgg agggattgga ggaaacatgg tcgaaatgat attgattgct 699301 acacattttt tggaagtttg tattctatat tgttttttaa ggagcatgtt gatgacgaaa 699361 aaacggatta catttggttt attagtttta atggtatgtg tcatcctgtt tgttctgtat 699421 gttcagttac gcaataaaga tagtattcct gtccaatctt ccgccattca ccccgaagaa 699481 gaccgcatct tttttattta ctccaatcct ttcataaaag aaagcgtgct gctttcaacc 699541 tctacaggcg aacggtttaa caggcgtacg tttaaggtgg cggatgtgcc ttatattcaa 699601 acgaaatctt atgcatcaac agaccttgta ttattggcgg aacacgagcc tttttactac 699661 acgctggaga aggatgtgat caaagagcat ccgctgtcag atccatttgc gttttggtat 699721 gaggggaagg atgtcactat tgaggcctat aatgttgata cgacgggaaa tgagatccac 699781 ataaacgaca gaaaaacgaa aaaggaatat acccttacct tgcctccgct tgtcacaatg 699841 ggggccagtg atgagaactt tatttatatc attcaaagca tgtctattta cgtgattgac 699901 agaaaaacag aggaaatgat tgagaccctg agcttagcct catacgctga tcaattcgca 699961 gactcggagg aatttatcgt cgcgagctcg gatcataaat tgactgtgat tgaaaaaggg 700021 acatggaaga cgacatatat tgcgtatcct gaagatcttg aatatgcaga tactgtgtac 700081 tatgacaaag aaagcggcag tttttacgtg gcgtacgagg acaaagaggg tggagcgaac 700141 ttgctggaat atggggagga tttttctatt cacacataca gcttgaaatt cccttatatg 700201 gaggcgaagt ttaaggggaa tctattgtat atagttgccc aggaagagca taaaaagggc 700261 atcggcggat acgtgggtgt gtttgatatc cattctaagg agatgcttta tcagtttgat 700321 ttgcctgagg aacaggtgaa ggttcaggat tttgttgtgg ttgacaataa gtgaatacta 700381 tatgaaatag aatgacaaag acccttgcat aaagggttct tttttatgaa aaaaacaaat 700441 tgacaggatg aaaaaacaat ttcttccttc tatattgttt tcaaaatttg ggattgatag 700501 aatatgacat atctcataga gaaggaggga agccgttgag tcaagccata ccgtcttcgc 700561 gtgttggtgt taagattaat gaatggtata aaatgattcg ccagttcagt gttccggatg 700621 ctgagattct gaaagcggag gttgagcagg acattcagca gatggaagaa gatcaggatt 700681 tactgatcta ttattctctg atgtgttttc ggcaccagct gatgcttgat tatttggagc 700741 cgggaaaaac atacgggaat cgccctacag tgacagagct tcttgaaacg atcgagaccc 700801 ctcagaaaaa actcacaggt cttttgaaat actactcttt gtttttccgc ggcatgtatg 700861 aatttgacca aaaagaatat gtggaagcga tcggatatta tcgcgaggcg gagaaagaac 700921 tgccgtttgt gtcagatgat attgagaaag cggaattcca ttttaaagtg gcagaagcgt 700981 attatcacat gaagcaaacc catgtgtcga tgtatcatat tcttcaagcc ttggacattt 701041 atcaaaacca tcctctatac agcattagaa cgatacaaag cttgtttgtg atcgccggca 701101 actatgatga tttcaaacat tatgataaag cgctcccgca tttagaggcg gcgctggaat 701161 tggcaatgga cattcaaaat gacaggttta tcgccatttc tctattgaac attgcaaaca 701221 gctatgacag atcaggagac gatcagatgg ctgtagaaca tttccaaaaa gcggcgaaag 701281 taagcagaga gaaagtgcct gatctgcttc cgaaagtctt gtttggatta agctggacat 701341 tatgtaaagc gggccaaaca cagaaggcgt ttcagttcat agaggaagga ttagaccata 701401 tcacagcacg ttctcacaaa ttttataaag aattgtttct gttcttgcag gccgtgtaca 701461 aggagactgt tgatgaacga aaaattcatg atcttttaag ctatttcgaa aaaaagaacc 701521 tgcacgctta cattgaagca tgtgcccgga gtgctgccgc tgtttttgaa agcagctgtc 701581 actttgaaca agcagctgcg ttttatcgga aagtgctgaa agcccaagaa gatattctaa 701641 aaggagagtg tttatatgcc tattaagaaa aaagtgatga tgtgtctggc tgttactcta 701701 gttttcggaa gcatgtcgtt tccaaccctg acaaactccg gtggatttaa ggaatcgaca 701761 gatcgaaata cgacgtatat cgatcattcc ccttacaaac ttagtgatca gaagaaagcc 701821 cttagctagg gctttttctt gctttacgga agacgttcca ttttccacat cgcggcattc 701881 cttctatttc taacgcaaga cactcgaaac aaccaaacca tttgaggtat aatggataaa 701941 gtgaataaca gtatttagat tgatatatat gaaagagagt ggaacatcat gggccgtaag 702001 tggaacaata ttaaagagaa gaaggcgtct aaggacgcaa atacgagtcg gatttatgcg 702061 aagtttggcc gtgagattta tgtggcggcg aaacagggcg agcctgatcc ggaatccaac 702121 caggcgctga aggttgtgct tgaacgtgcg aagacttaca gcgtgccgaa aaacatcatt 702181 gaacgtgcga tcgagaaggc gaagggcgga gcggaagaga attacgatga gcttcgttat 702241 gagggcttcg ggccgaacgg atcaatgatt atcgttgatg cgctgacgaa taatgtaaac 702301 cgtacggcgc cggaagtgcg tgcggcgttc gggaaaaacg gcggaaacat gggtgtgagc 702361 ggatctgttg cttacatgtt tgacgcgacg gctgtaatcg gtgtggaagg caaaacggct 702421 gacgaagcgc ttgaaatcct gatggaagcg gatgttgatg tacgtgacat tttagaagag 702481 gatgacagcg cgatcgtgta tgccgagcct gatcaattcc atgcggtgca agaggcgttt 702541 aaaaacgcgg gtgtcgagga atttacagta gcggagctga caatgcttgc gcaaagtgaa 702601 gtaacgcttc cggatgatgc aaaggaacag tttgaaaaat tgattgatgc attagaagat 702661 ttggaagatg ttcagcaggt atatcataac gttgatttag gtgagtaagg agtgagcagg 702721 ctgttatggc ctgctttttt tgtcccggaa attgttttag ctgtatgtag gcggccgcct 702781 atacgatcta taagatattc tcatactctg gactgtaacc tatgtgaagg agagagtaaa 702841 tatgactgat acaagacata tgtatggcgg acctggtttt ggtcattatc agggctttgg 702901 tattggccac ccgggctatg gcatgcaaag cacaggctat ccgggctatg gcatgtatgg 702961 aggccacccg ggctatggca tgcaaggcta cccagatcac ggcatacatg gaggagtcgg 703021 cggctatccg ggatatggtg ggtacggcgg ttacccaagc ggcggctatg gaggctctcc 703081 gggaactgga agctatccga gcatgcacca tgaaaatgat ggccatcacc actattatca 703141 ccatcatcat gatggaaaag ataatcttca tcaccatcat caccatgttg gaaaggataa 703201 tcatcaccac catcatgatg gtcattatgg ccaccatcat caccatatgg gccactgggg 703261 aaaagacggt tataaataaa gaagatgatg ataaaaagag gacactcttg cagatcaaga 703321 gtgttttttt agcttttttc ttgactgttc agtctggaaa atggtaacat ttgtttcagg 703381 aggtgatcat tttttgggga ggaataaaga atttgatacg gcgcttgttc ttcacagggc 703441 gatagaggtt tttggagagt atggctacga aggaacgtct cttcaggatc tgctctctca 703501 tttaggcatt gcgcgccaaa gtttgtatga tacgtatgga acgaagcgtg atttgttttt 703561 gtccgctgtg aaatcgtatc ttgaagggaa aaacgctgcc gttatggaaa ggcttgaagc 703621 gccaggatct gtaaaggaag ccattcgtga tatttttcag gagggtgtca atgccctgag 703681 ggatccggaa cgggcgaagg cgtgctacat tattaacagc gcgattgaac agatcccgca 703741 tgaccctgag cttgcccggt attttgaaag acaatccaag cagcttgagg acgcttttta 703801 tcacgggctt ttaagagcga aggatcaagg agaattgaat ggcgaagata ctgatatatc 703861 tgcgcttgct cggtacctga atcagagcag gctgtcactg acatttattg caaaagtgac 703921 ggcagatatg gatcggcttc aggaccatgt tgacgtgagt ttatcagtgc ttgattaaca 703981 tgtggtaaag gattctttgc ccatgtatgt actttttgga ctgaatagtc tagaaataaa 704041 aatgaggtga tgatgaatgt tgatgaatga gtttgaaaaa gcatgtgaaa cattgagaaa 704101 gtttatggct tatatgcttg agaaggacat gaagagctgg acggagcttt gggatgagaa 704161 tgctgtattt gagtttcctt atgcgccgga gggatcacca aaaagaatag aaggaaaagc 704221 ggccatttac gattatatta aagattatcc taagcagatt catctttctt catttaccgc 704281 tccgacagtg taccgttcag cagactcgaa tacggtgatt gcggagtttc aatgtgacgg 704341 ccatgtgatt gagactggac tgccttatcg ccaaagctat atcagtgtca tcgaaacgag 704401 agacggccgc attgtgcgtt atagggatta ttggaatccg cttgttgtaa aagaggcctt 704461 tggaggatca tttttgcaaa cagaggagag tgggaaatga tgaaacagaa tccgatttta 704521 atcacgggcg ggaccggcac agtcggcagc cgaatcgcca gccgtttaat aaagctggga 704581 tacagagtgc gtattgcaag ccggaaaaag ggcgcgcttg ctgatgctga gtatgtgtat 704641 tttaattgga agtacgcctc cagttttacg cctgctctgg aacaggtaaa acagatctat 704701 cttgttgctc cggtcggtgt atttgatccg gctccctatg tgcttccctt tttaaaggaa 704761 gcaaagcgtc tcggcgcaaa gcgggtagtg atgcaaagtg cgtctgttgt ctccgagaac 704821 ggtcccgtgt ttggcgcgct tcaccaggca gtgcgcgagt ttccagaatg gacggtgctg 704881 cggccctcat actttatgca aaatttcatc aatgtccagc accgcatgtc tattcaaacg 704941 gaggggcgca tcacaacggc ttcgggtgaa ggaaaacttg ggtttattga cgctgatgac 705001 atcgcagaaa cagccgtcag ggctttgatt gatgatgttc ctcatcaaac acatcatatt 705061 ctgacaggtc ccgaggcgct gagctatgcc gaagcggcgg agatcattgg agctgcggcg 705121 ggacgccggg tggagcatgt cagcatttct cgttccgagc tgcagcataa aatggaggca 705181 ggaggtttgc ccgcggatta tgcccatttt atggcgaagc ttgatgaggc aattagccat 705241 ggtgcggaac atcgggtaac ggatacagtg aagcgtgtga cgggaaaaga acctcgttcg 705301 ctgtcagagt ttgcggctgc tcatgctgca tattggacct cattttggac tgaatagtct 705361 agaaagacct tcggcgcttc cgaaggtctt cttattgaaa aagctaagtc gtgttttagt 705421 cataatcatg cctcctgcct catacctatt aaggtcattg tttttgagaa aggaggagcc 705481 ggaatgaagg atatgcagcc gtttacgcct gtcaaatcat atacgccctt tcacagccgt 705541 tttgatccct gtccgcccat agggaagaaa tattacagaa cgccccctaa cctttatatg 705601 acctttcagc ctgagcacat ggagcagttt tcgccgatgg aggctttgag gaaaggcacc 705661 ctttggaagg atctctatga tttttatgaa aacccttatc gagggggaga cgcacatggc 705721 aaaaaaggtt gacgccgaat attatcgtca gctagagcaa atacaggctg ctgattttgt 705781 gcttgttgag ctgagtcttt atttaaatac acatcctcat gatgaagatg cgttgaagca 705841 attcaatcaa tattccggct attcaaggca cttaaaaaga cagttcgaat cctcttacgg 705901 accgcttctg cagttcggca acagccccgc gggcaaggat tgggattggg gaaaagggcc 705961 atggccgtgg caagtataag gaggaatgcc tgaatgtggg tgtatgaaaa gaagctgcaa 706021 taccctgtca aggtcagtac gtgcaacccg acgctggcga agtatttgat tgagcagtat 706081 ggcggagcgg acggcgagct ggccgcggct ctccggtatt tgaaccagcg ttatacgatt 706141 cctgataagg tcatcggcct tttaacagat atcggcacgg aggagtttgc ccatttggaa 706201 atgattgcga ccatggtcta taagttaacg aaagacgcca caccggagca gctgcgtgaa 706261 gctgggcttg gcgatcatta cgtcaatcac gacagcgcgc ttttttatca taatgcggcg 706321 ggcgtgccgt ttaccgcgag ctatatccaa gcgaagggcg atccgattgc cgatttatac 706381 gaagatattg ccgcagaaga aaaggcgcgg gcgacgtatc aatggctgat tgatatttcg 706441 gatgatcctg atttaaacga ttccctgcgt tttttgcgtg agcgtgaaat cgtacactct 706501 atgcgcttca gagaagcggt tgaaatttta aaagaagaac gggataaaaa gaagattttc 706561 taataggcag attggcctct ctttcataca cccttttaca tacagagaaa atggtctgtt 706621 tttgcagttt ggtctgcatt ataatcaagg tgtgtgtgca agcttacttt ttgattggga 706681 ggcctttatg acagctttta agattgagaa cgaaacgatt gcagatggat tttacgcgtg 706741 tccggccgtc tatgaggatg cagaatcgat taccgggttg ctcgtccgaa cagctgaatg 706801 gctccgggat cggggttcta accaatggag cggacttctc aaagggcaag atatacatga 706861 tatcacgggg tcaattgaaa agggacatgt gtttgtgttt aaaaaagatg aagagcttgc 706921 ggctgtcgtg atgctgctgc ctgcaccgag cgagtgggac cggacgcttt ggggagacga 706981 tgggcatgag gagtccattt atttacaccg cctcgcagta agccgccggt ttgcgggaca 707041 ggggcttgga gcccgcgtcc ttcagtgggc ggagacgggc atacactttc cggaaaaaac 707101 gcggatccgg cttgactgtg tcgctgatag tgacgccctg cattcctttt atcggcgtat 707161 gggatatgaa ttcatgggtg ctgatgcgtc cggatatcat ttgtttgaga aagagattac 707221 ggcagaataa gcgtcctttg cagggggctt ttttgtcttt ttctaaaagg gaggcaggcg 707281 atgtgtggtc aatattattt gtgacaggga ttgtgacggc ttgtctgttt gctggcgtat 707341 ccgtattgat gcggatgaga tttcctgaca aaagtcggcc ggaatggatg ttggccgggc 707401 tgatcgtcct tggtgtgttt gcgatctggt acagcctcgt gtatgtacgc ggctgggaag 707461 gggctgcgct cggaatgctt ggattcaatg tcattttcgg agccattgcc ggatatttga 707521 tcgataaggc catccggcgt tacaggaaaa gataaggctg ctgccgtctc tcaacaggtc 707581 gaaattttca cagaccggca ggaattttct ttcgaaagga gaaatacata ttactttaaa 707641 atgaaagcgt tttccaaagc aggaaggtga tgttgatgat acacagtgtg gcaaatgggc 707701 tgaatcattt ttgtacgtgg gtgatgagac tggcctattt gaatgtgctt tggattttgt 707761 tttctcttgc aggcctggtt gtatttgggc tgatgcccgc tactgccgcg atgtttacag 707821 tggcgagaga atgggcgaag gggaatacag atgccccggt gttttctgtc ttttttcgga 707881 cgtttaaaaa ggaatggcgg gcatcacaga tcctcgggct tatcgttgtg acggctgccc 707941 tgtttctgtt tgcggatatg cggatagcgg ctcagatgga ccagcctgtg ctcgtcaatg 708001 tattcgtgag cattagtttg attttcgcgt ttgttgtgct gtatgtgttc ccggtatttt 708061 ctcattttga cgtaaaaatc agagaggtgc tgagcatcag ctttttcatt gccttcagtc 708121 gtccggcggt gacgcttttg atggcagcgg gcgctgtcgg tgtgctttgt ctcgttctgt 708181 ttcatgtcac gtttctattg tttttcagcg ggagtttact cagcctgatc ttaacgaagc 708241 tgtcctttaa agcgtttcgg tcaatggatc agcggcagga gaaagaaaag gcggcatgaa 708301 gaaaagagtt gctggctggt acaggcggat gaagattaag gataagctgt ttgtgtttct 708361 atcgttgatt atggccgtat cctttctgtt tgtatacagc ggggtccagt atgcctttca 708421 tgtgtatgat gagcagattt accgcaagtc ctcggaggtg cttcggatgt cttctgaaag 708481 gatcgaagac gagctgaaga agatagagga tgtgtcatat gaaatcatta cagacgaaca 708541 gattcagcgc atcctgagca tgcaaaatcg ggatgatacg tatgatcaat atcaaatgaa 708601 gcaggagctg tgggatcagc ttgcgggata tgccagcgat gaaaagtaca tcgattccat 708661 tcatgtgatt gatgcccgcg gctcagagta ttcagccgga agcagttctt cagatctttt 708721 gcagcaggag caggaagagg tatttaagcg agcgaaagcg aaaagtggaa gaaatctttg 708781 gatgacgctc ggcgggtcag accccgtcct gatttcagca cggcagatca ggtcctatca 708841 ccagctgagt ctgaacggct tgggcatggt actgatccag gtcaatgtaa aacagatgat 708901 tcgtgatgtg ccgaaggatt ggggcgattc agtcggagac attatgattg ctgaccaagg 708961 cggtaatttg gtgtatacgg cacatgcatc agcgcatgtt cctgaggcag caaaagagac 709021 gttgaagcac cccggttatg acttgataaa aaagaatggc aaacgttact ttatttctta 709081 tcttcaatca tcctaccaaa attggagcta ctataacgtt atcccctttg atcagatgtt 709141 cgcaaaaatt tcctttatga aaacagtgat cggcacatgc tttcttctct ttttctgtgt 709201 ggttttgctt ttcggaagga aaatcgccaa cagcatcacg gagccgattg aacagcttgt 709261 gaccgcgatg aaatcggtac agcacagcgg cattgaagca ggtgtgtcgc tttctctgcc 709321 ggaacataca caggatgagg ccggcatgct gaaccgccat tttactgtca tgatgaaacg 709381 gattaatgag ctgatggaag aaaatgtgga aaaacagctc atcattaaag aaaccgaatt 709441 gaaagcactg caagcccaga tcaatccgca ttttttatat aacacgctcg agtccatcaa 709501 ttggctggcc aaggcgaatc agcaaaagca aatctcaaaa atggtggaat cgctcggttt 709561 tcttctgcga aacagcatac atatgaagaa ggatatcgtg accattcagg aggaggcgga 709621 cattgtacgt cactatatga ccattcagcg atttcgattt gaagagcgcc tgaaattcac 709681 gttggatatt gacgatgagg tgaagcattg cctcattccg aaactgacgc tccagccgct 709741 tgcggaaaat gcgattcaat acgcgcttga accctttaca aggccatgcg ccatccggat 709801 tcaggcgaaa aaggcgaagg gctgtgtctg tattacggtc gaagataacg gccctggcat 709861 ggatggacgg attcttgaat caacgggtgg aagaggaatc ggactttgga atattcgcga 709921 gcgcatcagc ctgacattcg gagagccata cggattgcgg attcatagtg agcatgaaaa 709981 ggggacgagg attgtgatca caataccgtg ccgaaatgag gtggtgtgat gtataaaata 710041 ctgctggctg atgatgagag gattatcctt gatggaatgg cgggaatcat tgagtgggag 710101 tcgcttggcg cctcattgat cggaaaagcg cagaacggac atgaagcata tgaaaagatt 710161 gtacataagc agccgcatat cgtcatcaca gacgtcaaaa tgcccggcat ggacgggctt 710221 gagctgatca aaaaggtgtc agccgtcagc ccgtcggtgc aatttatcgt cctgtccggg 710281 tttggagagt ttgagtacgc aaaggaagcc atgaaatatg gggtgaagca ttatttgctg 710341 aaaccctgca atgaacagca gattatcagc tcgctggagg aaatcattgc tgagctgaag 710401 cggcaagatg tgcacaaaaa gaaaacagcc catctgaaac acgagctgga ccatatccgt 710461 tcctttgcag ccgatcaata cttggaaggc ttgatcgccg gtgtggccca gctttctccg 710521 ccgccttcac ttgccggaaa aaagatccgc ctcttgatct taaaagggga acaatctatt 710581 gatgctgcag ccagagaggc actcggatcg gcactgacag cggtttgcag cagcggtgaa 710641 tggaccgtgc tcgccgtaga ggagaacgcc gctgaaaagg tggcggaggt ttttgcggac 710701 cgcaagatgg ccatcagtca ggcgggagaa ctccggcacg cggggcagct gtttcgtgac 710761 acagctgaag cgtctggtga cctgcatggg agcgcagtga tttcaaaaat gatcaggctt 710821 attgccgacg agctcggaaa tccgaatctg tccttaaaat gggcggcgaa ggatatgctg 710881 tttatgaatc ctgattatct cgggaagtta tttaagcagg aaacaggcga gaaattttcc 710941 caatatgtta cacgggtgcg tcttgagcat gcgatgaagc agatgaaaat aaggagggac 711001 gtgagcgttt cagaaattgc tgaagaaatc gggtttggcg ataatccgaa gtatttcagt 711061 cttgttttta aaaaatatac cggtctgaca ccgtcagaat tcagaagaaa acagggaggc 711121 gcttccgcag gatagccatc tctgtttttt tgactttcgc cactgttttt tgagtgtttc 711181 gccctatccg aacgctttaa aataaaatgt aagcacttac attaaagggg ggattggttt 711241 gaagaagatt tgttacgtgc tgttatccct tgtctgcgtc tttttgttca gcggatgttc 711301 agcgggtgaa gaggcctcgg gaaaaaaaga agatgttaca ctcagaatcg cgtggtgggg 711361 cgggcagcca aggcatgatt atacaactaa ggtaattgaa ctatacgaga aaaagaatcc 711421 gcacgtccat attgaagcgg aatttgcgaa ctgggatgac tactggaaaa agcttgcgcc 711481 catgtctgcc gccggccagc ttcctgatgt cattcaaatg gataccgctt acttagccca 711541 atacggaaag aagaaccagc tggaagattt aacgccgtat acaaaggatg gaacgattga 711601 cgtcagttca atcgacgaga atatgctgtc gggcggaaaa atcgacaata agctttatgg 711661 atttacgcta ggtgtcaacg tgctgtctgt gattgccaat gaagatttgc tgaaaaaagc 711721 cggtgtgtct atcaatcagg aaaactggac gtgggaggat tacgagaagc tggcgtatga 711781 tcttcaggaa aaagccggtg tctacggttc caacggaatg catccgcctg atattttctt 711841 cccttattat ttgcgcacaa agggtgagcg cttttataaa gaagacggca ctggcctcgc 711901 gtatcaagat gatcagctgt ttgtcgatta ctttgaacgg cagctgaggc tagtgaaagc 711961 gaaaacgtcc ccaacacctg atgaaagcgc acagattaaa gggatggaag acgattttat 712021 cgtcaaaggc aaatcagcga ttacatggaa ctactccaat caatatttgg gctttgcccg 712081 gctgacagac tcgccgctgt ctctctatct gccgccggag caaatgcagg aaaaggcgct 712141 gacactgaag cccagtatgc tgttttccat tccgaaaagc tctgagcata aaaaagaggc 712201 agcgaaattt attaatttct tcgtgaataa tgaggaagcg aaccagctga ttaaaggcga 712261 gcgaggcgtt ccagtctccg acaaggtggc ggatgcgatt aaaccgaagc tgaatgagga 712321 agaaaccaac atcgtggagt atgtagaaac cgcgtcaaaa aacatcagca aagccgatcc 712381 gccagagcct gtgggaagcg cggaggtcat caagctgctg aaagatacgt cagatcagat 712441 tctgtatcag aaggtatcgc cggaaaaagc cgccaaaacg ttccggaaaa aggccaatga 712501 gatattagag aggaataatt gacgggaaat ggggctgacg caatgaaaaa aagccggagt 712561 ataagaaaag acaatctggc gggatatgct tttatttctc cgtttatcat cgggttccta 712621 tgctttacgg tgattccgat gggggcgtcc ctgtttctgt ccttcacgag ctatgacttg 712681 tttacggcgc cgaaatggat cgggctcgac aactttaagg aaatgtttac gggtgacgaa 712741 aagtattggc agtctctgaa ggtgacgttt acgtatgtgc ttgccggggt tccgctccgc 712801 ctcggcttcg cgctttttat cgctgtcatt ttaaacaatg cagcaaaagg aacggccatt 712861 tacagaacgc tcttttatct gccttcgatc atcggcggga gcgtcgccgt ggcgattatg 712921 tggcgcaata tttttggcaa tgacggggtc atcaatgcgc tgctgttttt tgtcgggatt 712981 gatcaaaaaa ttctttggta ccagaatccg acaagtgcgc tgtggacatt gattctgctg 713041 tccgtctggc agttcgggtc gtcaatgctg atttttttgg ccgggctgaa aaacattccg 713101 tcttcgtatt tggaagcggc aagtgtggat ggggcaaatc gggtgcagcg tttcttcaag 713161 atcacgcttc cgatccttac accgattatt ttctttaacc tagtgatgca gacgatttct 713221 gcttttatga catttacacc tgcctatatc atttcgaagg gcgagggcgg gccgcttgac 713281 gggacacttc tctattcgct ctatttgttc cagcgtgcgt ttaactattt tcaaatgggc 713341 tacgcatcgg cgatggcgtg ggtcatgctt gtcattgtcg ggctgattac gctcatattg 713401 tttaaaacat cgtcatattg ggttcattac gagtcaaagg aggaatgacg gatggagccg 713461 gtcaaccagc ctgtcagaga agccccggtt tttgagagaa aaaaagccgg gcgcgtcagt 713521 cccaaacgca tactgttcca tgtttttacg gcaacgctgg cggtgttgct gctgtacccg 713581 gttatttggc tgtttgtcag ctcgtttaaa gaaagcgcca gtatttttac aacctcacat 713641 tctctcattc cagacccttt tattctcagt aactatgctg aagggtggaa gggcattgcg 713701 ggacagccgt ttctgacgtt tattaaaaac tcggcgatta ttgtcgggct gtcaacaatc 713761 ggtgccgtca tgtcatcggc tgtcattgcg tacggatttg cgcgtatacc gtttaaggga 713821 aaaaaatttt ggtttgcgtg catgatgggg acgttaatgc tgcctcatga agtgttgatg 713881 attccgcagt atattatgtt tgcgaaatta gactggctga attcctttaa accaattgtc 713941 gttccgcaat ttttcgggca tgcgtttttt atctttctga tgatccagtt tatccggacg 714001 attcccgagg agctggatga agccgcgcga atcgacggat gcggacgctt tgcctgcttt 714061 tggcggatca ttctcccgct gattgccccc gcgcttgcga cgtctgcgat tttctccttc 714121 tattggaagt gggaggagct gattcagccg ctcttgtatt tgaataagcc ggagctttac 714181 cctgtttcac ttgcgctgaa gctttttctc gatacagagt cggcttcgaa ctggggcgcg 714241 atgtttgcca tgtcagccgt ctcgttattg cctgtgattc ttgttttctt tttgtttcag 714301 aaatatatcg ttcagggcat cagtacgacc ggattaaaat aaaaaggagt gttgcagatg 714361 gcacagctta tctttgatga agaaaaggtg acgtcggtta ttgaccggat cgtgaaacgg 714421 acatttcaga tggattttgc gtgggattgg ccgggcggcg ttgcgtttta cggtgtggcg 714481 gaggcctatg aagcgacgga aaacgaggaa tatatcaatc tgttaaaaac gtgggtggat 714541 gaacagctgg aggatgggct gccgccgctt tcgatcaacg gagtttccat tgggcatacg 714601 cttttgttcc tccacaaggt gacaggtgat gacgtgtatt tggaaacagc ggccgagatg 714661 gcggaatatg tgctgcataa ggcgccgcgc tttggcgagg gtatccttca gcatacggtg 714721 aatgcggcag aatacgtatt ccctgaacag gcatgggcgg atacgctgat gatggctggg 714781 ctgtttatgc tgagaatcgg gcgggtcatg gagcgtgagg attattttga agacggcctg 714841 cgccagtttc acggacatga ggatgtgctt caggaccctg tcacgaattt gtactaccac 714901 gcctgggaca acaaagcgca aaatcatctg tcggggattt attggggcag ggcgaacggc 714961 tgggcggcac tcacgatggc aaaggcgctc ccgcttattg aggtgacaca tccttccttt 715021 atgatcatcg acggatcgct cagagaccag ctgagcgcgc ttgtccggct tcaggatgaa 715081 tcagggctgt ggcatacaat tttggatgat ccggattctt atctggaggt ttcggcatca 715141 gcgggtattg cttctgctct gatgtcgagc ggaaagctgt atacaaaata tgtgcagaaa 715201 tcgcttgccg ccattttgga tgcagtggaa gaggacggac gggtcagcag ggtatcggcc 715261 gggacagccg tcatgaaaaa tgccgaagga tacaaacagg tgccttacaa acgaatacaa 715321 ggatgggggc agggacttgc gctgacgttt cttgctgatg ttttgaaaac gaaaaaacgc 715381 ttgtatcagt aaagatagcg gcggggggag agggatgaaa aaacagcctc aacagaagga 715441 acgggtttct cgctggaagg gaacgtattt caaaagaaac tttgtcttca ttttgctgat 715501 tgcctgtatt cccggattgc tgactggcgg cgcaatctac tttctttcga tcgacaaggt 715561 ggagaaagag ctgcagagat cgcatgaaac acaggtggcg cgtgaggtca gccgaatgga 715621 tgagaagctg ggagtgcttg aactggcact cacccagatg gcctacgatt cttcactgat 715681 gaacggattg gccgagaggg atttggagaa agactttacg ttctcctatc aattaacgaa 715741 aaagctgttt cttttgcggg atcagcagcc gctgatcgag caggcttcca tctttctgaa 715801 cagcccccgg ccacttgtgc tgagccctga atacagcgct ttgacagaac aggaggcgct 715861 tcgcaagtat cgctcgctgc ttgcctcaga ccacagcatt tattggaaac ggtcgggaaa 715921 ccaagcgatg ctgatccagc tcattccggg cgcggcggag aaaccgttcg gcgcgatcat 715981 gctggcggtt gatccgaaag aaatggaatc aatcctgcaa agcttgtccc cctatcctga 716041 tggcagtgcg ttgcttttag atcaaaatcg agaggtgctg tttcatgagg gggaaaaaga 716101 ttttgaaaag actttacttc atgagataaa aaaacagcct gctgagaacg gccattttca 716161 gatggaatgg aaaggcaagg tgtattctgt ctcctttgga gaaatgaacc ggatgcatca 716221 gcaatggacc tttgtgtcag cggcgcctct ttcagctatt acagcgccga tggtgttttt 716281 atcaaaagtg atcatcgtga tgctggtcat ttgcatcggt ttggcggtgt gcatgacatg 716341 gtatgcatca aaaaaaatct atcgtcccat ccagcatttg cttggcttgt ttaccggagg 716401 agagaagaaa acatggcagg cgtccgggca ggatgaattc aaatggattg aaaagagatg 716461 gcaggatcta tcccttgaaa gccggaagct ccaacagcag ctcctgcggc agacgcccca 716521 tatgaaaaag agttttttgc agcatctctt acagagcgat ttttactatg acaacgagga 716581 aagcctcaga tttcggatgg aggaggctgg ctggaacatc ggcggaaacg tgtttcatgt 716641 gcttgatcta caggtgacag ggctccgctg tgaaaaaagc atcttccgtg aaggtgatga 716701 acagcttgcc gtgtttacac tgactaatat cgctgaggaa ttggcggcta aacgcgtttt 716761 tcagctctcc atacttgata tcggccggct ttctgtcacc gttcttgtga tgaaaacaaa 716821 cagctctgat ctgaaggcgt atataacgga gctggcacgc caatttggag atgtaaccgg 716881 actatgcctg acctcgacat tgagcagcaa gacggagcgt gtcacggaaa ttccttcttt 716941 atttcaggat gtgaaatgcg gcaaatcccg caggaagttt gctaaccggg atcaggtcat 717001 tgatttgcag gccgacttcc ctcgggatga gcagttcgct ccttattacc cttttgagct 717061 ggaaaaacaa attgttcaga ccatccggct ggaaagaaaa caggaagcca aggaactgat 717121 agatggatgt atgaaggaac tgtcggaaaa agcggccata gacaggcatg tgcattccgc 717181 cctgattcag ctgttttccc gcattcagga ggatattttg cattccgggc tcaatcccag 717241 cgaactgttt cagcaccgga atccgtttct tgatatttca gaattgcgcg aacctaacga 717301 agcggcggcc tggctgatgg atgtagtggt gacgccttac ctttccaagc ttgagggcag 717361 aaaaaacaga cagcaaaagc agctggcaga acgtgtgatt gcgatgattc acgaacagta 717421 tatggcggac atttcattgg aaagctgtgc cgatgcgctt ggcatgaatt cctatacgtt 717481 aagcaaggca tttaagcaag tgaccggcat taattttatc gattatgtga cccagatcag 717541 aatcgaaaag gcgaaagaac tgctggtcaa tacgaataaa aaaattcatg atgtgtctga 717601 agaagtcggc tatcgccaca attatttcaa tcggattttt aaaaaacagg tcggcatgcc 717661 gccgggtgtc ttcaggcaaa tgtatcagga aacgccgtga aaggagagaa catgtgatga 717721 agaaaccgat tcaagtattt ttagcggggg attccactgt gagtgactgc ccgcctcatg 717781 aagcgccgat ggcggggtgg gggcaggtat tcgggcaatt gttttctgaa ggtgtgctgg 717841 tccgcaatca tgccaaagga ggagcgagca ccaattcttt tgtggaggaa ggaaggcttc 717901 aagcaattgc cgagcacatc acacaaggcg attatttgtt gattcaattc ggccacaatg 717961 accaaaaacc gcgggggacg aagccgtact ccacatttca gcagtttctt accttgtttg 718021 cagatacggc acgcgaaaag ggcgcgcatc ctgtgttcgt cacatcggtg cagcgccgcc 718081 gctttgatga aaacggacgg atcgagcata cgctcggtga gtatcccgat gcgatgaaag 718141 cactggcgaa ggagctcgat gtacctgtga ttgatctgct tgcgaaaaca aaggtgctgt 718201 atgaagcata cgggccggag gagtcgaagc gattgttcgt ttggtttcag ccgaatgaac 718261 atccgaatta cccggacggc attgaggaca atacgcattt ttcggaaaaa ggtgcaatgg 718321 aggttgcgaa gcttgtggca gaaggcattg aagagctcgg acttccgctt aaggaccacc 718381 ttgtgagccg ggagggaaaa gaacatgtat aaggaaggcg cttgcttgta ccgcaatccg 718441 ctccggtcta aaagcgatgt gaaggattgg cggatggagg gaggcggaca gatctcattt 718501 gacgatcaca gcttgcacct gtcacatgtc caggatgaag cgcactttgt cttttggtgt 718561 ccggaaacct ttccagacgg catcattgtg acatgggact tctctccgat cgagcagcct 718621 ggactgtgta tgctgttttt tgccgctgcg ggtattcgcg gcgaggattt gtttgaccca 718681 agtctcagga aaagaacagg aacataccct gagtatcatt caggagatat caatgccctc 718741 cacctgtcgt atttccgcag aaaatacgcg gaggaaagag cgttccgcac ctgcaattta 718801 agaaaaagcc gcggtttcca tctcgccgca atgggggccg atccgctgcc ttctccagac 718861 gacgctgatt ctccgtatcg tatgaagctg atcaaagaca aaggctatgt gcacttttca 718921 atcaatggtc tgcccattct tgagtggatg gacgacggca gcacatatgg gcctgtgtta 718981 acaaaaggaa aaatcgggtt ccggcagatg gcccccatga aagccgttta cagggatttt 719041 gccgtgcatc aagcggtgag aagatgaaga cgactgtaac ggatgcgctt tatgcaggct 719101 gcgaagcggt ggtgaaaata gcatggctca acgggctgtg gctgttgttt acacttttgg 719161 gcggcgttct tttcggatgg gcgccgagca cagctgcgat gtgtgccgtt ataaggaaat 719221 ggctgatggg gcaaaaggat gtcccgatat tttcgttatt tctcgatacc tataaaaaag 719281 agtttctcaa ggttaatgcg atcggattgg cgttttcggc tcttttgctc atattgtctg 719341 ccaactatca ttatttttct gccagtacga attggctgtc ctttgccgta acaagctgca 719401 cgctgcttgc agggcttttg tatatcatcg cgctgatgta tgtgtttccc ctttatgtgc 719461 attaccagct cccgcttcgc aaatatattc cgcaggcact gctgtttggc gccatgagac 719521 cgctgacaac tggctgtatg ctgatcgggt gcggatttgt cctttatttg ctgtatacgc 719581 ttcctggcct gatcccattt tacggcccgt gtttatttgg gcttgtgttg atgttttttg 719641 ctcttagggg atttcaaaag acggaggccc agcaccatca agccgggtaa caaaaaaatg 719701 acaaataagc aaaaaagtgc agtgtccgaa ataggcagat gcaaaaaagt gaaattgaag 719761 acagctcaca aagcgcataa aatccaattt aagtaagcgc ttacagataa atgagaagga 719821 gctgtctgat gattagacga aggaaacgca tgtttaccgc tgttacgttg ctggtcttgt 719881 tggtgatggg aacctctgta tgtcctgtga aagctgaagg ggcagcgcgg cagatggaag 719941 cgctgaaccg ggggcttgta gcggtcaaga cggacggggg catttttgtc agctggcggt 720001 ttcttggaac cgaaaacgca tctgttttgt tcaatgtgta cagagacggg caaaaactga 720061 atgctgcgcc tgtcaaaaca acgaactatg tggataaaaa cggttcggcg ggctcaacgt 720121 atacggttcg ggctgttgta aacggtaccg aacagccggc ttctgaaaaa gcctccgtat 720181 gggcgcagcc gtatcattcc gtcccgctgg ataaaccggc tggcggcacg acgccaaagg 720241 gtgaatctta cacgtacagc gctaatgacg caagtgttgg cgatgtggat ggtgacgggc 720301 aatacgagct gatcctgaaa tgggacccgt ccaactcaaa agacaattca caggatggct 720361 atacgggtga cgtgctgatt gacgcgtata aactggacgg cacaaagtta tggcggatca 720421 atctcggcaa aaacatcaga gcgggcgcgc actacaccca gtttatggtg tatgaccttg 720481 atggtgacgg aaaagcagaa gtggcaatga aaacggcaga cgggacaaaa gacggcacgg 720541 gcaaagtaat tggaaatgcc aatgcagatt acagaaatga acaggggcgt gtgctttcag 720601 gccctgaata tctcactgtg tttcaaggtt caaccgggaa agagcttgtc accgcaaatt 720661 ttgaaccggc gcgcggcaat gtgtcggatt ggggagacag ctacggcaac cgtgttgacc 720721 gttttctcgc cggcattgcc taccttgatg gacagcggcc gagcctgatc atgaccagag 720781 ggtattacgc taaaaccatg ctagttgcct ataacttcag ggacggaaag ctgtcaaagc 720841 tttggacgct ggactcctca aagtcaggaa atgaagcgtt tgccggacag gggaatcaca 720901 acctgagcat cgcggacgtt gacggggatg gaaaagatga gattattttc ggctcaatgg 720961 ctgttgatca tgacgggaaa ggcatgtact cgaccggctt aggccatggg gatgccctcc 721021 atacaggaga tcttgatccg ggccggccgg ggcttgaggt gtttcaagtt catgaggaca 721081 aaaatgcaaa atacggctta tctttccggg atgctgcaac tggaaaaatc ctttggggcg 721141 tttatgccgg caaggatgta ggccggggaa tggctgctga tattgacccg cgttatccgg 721201 gacaggaggt gtgggcaaac ggttctctct actcagcgaa aggggtcaaa atcggaagcg 721261 gggttccgtc ctcgaccaac ttcggcatct ggtgggacgg cgatctgctc cgggaacagc 721321 tggacagcaa ccgaattgat aagtgggatt atcaaaacgg cgtatcgaaa aatatgctga 721381 ctgcatcagg cgcagcggct aacaacggca caaaagcaac accaacgctt caggctgatc 721441 tgctcggtga ctggcgcgag gaagtggtgt ggagaacgga ggacagcagt gctctgcgca 721501 tttacacgac gaccattccg actgagcaca ggctgtatac gctgatgcac gatccggtgt 721561 accggcttgg catcgcctgg caaaatatcg cctataacca gccgccgcac acaagcttct 721621 ttttaggaga cggcatggcg gaacagccaa aaccaaatat gtatacgcct taactgaaag 721681 ggggaaggaa cgggctgcgc gcagcccgtt cccatcaaat gaaaccaaaa aagaggcaaa 721741 tggaatacct gaccagaggt ttgattgcgg tacagacaga acagggcgtg tttgtcagct 721801 ggcgttttct cggcacggat catgagacga cggcttttca cctttatcgg gatggaaagc 721861 ggatcacccg cgatccaatc gctgaaagca ctaattttct cgatcaaaac ggaacggctg 721921 actctgttta tcaagtggcg gctgtcaata aaggacggga agaaaagctt tccaagaaag 721981 ctcgtgtttg gcaggaaaat gtcctggagg ttcctcttgc caaaccggaa ggcggtgtga 722041 cgccggacgg aaagccgtac acttacagcg ccaatgatgc cagtgtcggg gatatagacg 722101 gggatggaga atatgaaatg atcctgaagt gggacccgtc caattcaaaa gacaacgctc 722161 atgacggtta taccggggag gtgctcatag atgcctataa actggacggc acctttttgt 722221 ggcgcatcaa cctcggcaga aacatcagag cgggtgctca ttacacgcaa tttatggtgt 722281 atgaccttga cggtgacgga aaagcagaaa tcgccatgaa aacagctgac ggcacaacag 722341 acgggaaagg acatatcatc ggtgatgagc aggccgattt tagaaacgaa cagggcagaa 722401 ttttgtccgg tccggaatat ttgaccgtgt ttaaaggaga aaccggtgag gcgctcacga 722461 ccgtggaata tgaaccgccc cgcggcaagc tggaggattg gggagacggc tatggaaacc 722521 ggatggaccg ttttctcgcc gggaccgctt atttggatgg ggagcggccg agccttgtta 722581 tggcgcgcgg ctactatacg agaaccgtgc tcgtggcata cgatttcaga aacggaaggc 722641 tcaaaaaacg atgggtattt gactccaacc agccgggaca tgaagcatac gcaggacagg 722701 ggaaccacag cttgagcgtg gcggacgtcg acggagacgg aaaggatgaa atcatatacg 722761 gcgcaatggc tgtcgatcat gacggaaccg gcctgtactc aacgggcctc gggcacggag 722821 acgcgatgca tgtaggggat ctggacccgt cacgaaaagg gcttgaagtg ttccaggtgc 722881 atgaggacgc cacgaagccg tacggactgt cgctgcgaga tgccggaacc ggtgagatat 722941 tatggggcgt ccatgctgga actgacgttg gccggggcat ggcggctcat attgatccaa 723001 gctacaaagg atcgctcgtc tggggaattg atccgccggg caatgatggc atgtcgtacg 723061 ggcttttcac gagcaaaggc gaaaaaatca gcgacaaagc gccctcttca gccaatttcg 723121 ccatctggtg ggacggtgat ttggtcagag aactgcttga tcatgactgg gacggaacga 723181 tcggcaggcc aaagattgaa aaatgggatg ctgaaaacgg ctgtctgaag acgatatttc 723241 agccggccgg cgtgttgtcc aacaacggca cgaaaggaaa cccggttctt caggccaacc 723301 tgttcggaga ctggcgggaa gaagtgatat ggagaacgga agacagcagc gcgctccgta 723361 tctatacaac aacacatctc acccgccact gcttttacac gctgatgcat gatccggttt 723421 acaggctcgg catcgcctgg cagaataccg cctacaacca gccgccgcac acgagctttt 723481 acctcggaac gggaatgaaa aaaccgccga agcccgccct gtacatagcg ggaagcaaag 723541 cggaggcgcc gctgtaggag gactaaggga taagacgcaa aggctgaacg ctacgccaag 723601 atgattagag aactggcagg acgaaccaat gctcaagcgc tgtacgcacc ggttttttca 723661 agggaagagc tatccgtgat ggaagctgta taaaaaacga ggaggaatga aaaaatggca 723721 aatcatattt atcttgccgg cgattcgact gttcaaacgt atggagacag cacaaatcaa 723781 gggggctggg ggcagtttct cggctcgcat ctgccggagc atattcaagt gatcaacaga 723841 gcgatcgggg gaagaagctc gaaaacattt gtggaagagg gcaggcttca ggcaatcctc 723901 gatgtgattg agccggatga ttggctgttc gtgcagatgg gccataatga cgcgtcaaaa 723961 aataagccgg agcgctacac cgagccctat actacttata aacaatattt aaagcagtat 724021 atcgcaggcg cgcgggaaaa aggcgcccat ccgcttctca ttacccccgt agcccgcttt 724081 cattacgaaa acggcgtgtt tttgaacgat tttcctgatt actgcattgc catgaagcag 724141 acggccgctg aggagaatgt ccagctcatt gatctgatgg agaaaagtct cgctttcttt 724201 actgagaagg gcgaggaaaa agtgtacacc tattttatga tttcagaagg gattaacgat 724261 tacacgcatt ttacaaaaaa aggcgcaaat gaaatggcga aacttgtggc aaaaggcata 724321 aaggagctcg gcctgccatt gacagaatcg atcatcaaag aaaggtgaaa atgtgatgag 724381 aaaactgtat catggcgctt gctattatcc ggaattatgg gatgaagaga cgattcagca 724441 ggacattgac atcatgcgtg aagttggcgt aaatgttgtg cggatcggcg aatttgcctg 724501 gtcagtcatg gaacctgaag aaggaaaaat tgacgtcggt tttttcaaag aaatcatcgc 724561 ccggctgtat gatagcggga tcgaaacgat tatgtgcacg ccgacgccta ccccgccgat 724621 ttggttctca catggccggc ccgaacgcat gcatgccaat gaaaaaagag agatcatggg 724681 gcatggctcc cgtcagcatg cctgtacgaa caacccgtat ttccgaaaaa aagccgccat 724741 catcaccaca gccatcgcca aggagcttgg ccggctcccg gggctgatcg gatggcagct 724801 agacaatgag tttaaatgcc atgttgcaga atgcatgtgt gagacatgct tgcgcctatg 724861 gcatgactgg ctcaaaaatc gctacggggt aattgagcgc ttgaatgaag cttggggaac 724921 cgatgtgtgg agcgagacct atcagacgtt tgagcaagtc ccgcagccgg gaccggcccc 724981 gtttctgcat catgcctctc tacgcactat gtatcagctg ttttcgatgg agatgatcgc 725041 ttcgtttgcg gatgaacagg ccaaaatcat ccgctgctat tcagatgcgc cgatcacgca 725101 taacggatca gtcatgttca gcgtggacaa tgagcgaatg tttcagaatc tcgattttgc 725161 ctcctatgac acgtacgctt cgcaggaaaa cgcctctgcc tttttattga actgtgattt 725221 atggagaaat ctgaaacaag ggcgcccgtt ttggattttg gaaacgagtc cgtcgtatgc 725281 cgcctcgctt gaaagctccg cttacccgca cgcagacggg tatttgcagg ccgaagccgt 725341 atcgtcctac gccttaggga gccaggggtt ttgctactgg ctatggcgac agcagcgttc 725401 aggcagcgag atttcccacg gttcggttct cagtgcctgg ggcgaaccca ccatcggcta 725461 tcaaaatgtg ctggcggttg agcgggcaag aaaggaaatc gagcctatta ttctatcgac 725521 tgaacccgtt caagccgagg cggcgatgac ttactctgac agagcaaaag catttattaa 725581 aactgagcct caccggggac tccggcatcg ttcgcttgtg acgcattttt atgaacgtat 725641 tctcaacacg gggattcacc gtgaccttat tccggaaggc gctccactgg acggctatcg 725701 cttgctgttt acgccatttg tgccgtattt gtcttctgaa tttatcaaaa aagcttcggc 725761 attcgctgaa gcgggcggca tctggatcac cgggccgctg acaggaggac gcacatgcga 725821 gcataccatt cataccgatt gcggacttgg cgaacttgag aaaacgtcag ggatcaaaac 725881 actttttacc tttccgatga atgagaacgt gaatacagga aaagcgtttg gcatcacggc 725941 gccgctcgga ctgtggagcg cggtgtttga cacagagagc ggaaacaccc ttggcacggt 726001 tgaagcagga ccgggggcgg gccatgcttt tctgacggaa cggaattacg gcgaggggaa 726061 aattgtcatg ctgggctcgc ttccatccgg gaaagaaggg gatgcgatgc tggaagcgct 726121 cgtcaggcat tatgcggagg aagctgttat ttccagccgg tcggatgtga cacccggcac 726181 gatcgttgcc ccgcgtatag gcgaaaacgg ccttgtgtgg atcgttgtga atatggatgg 726241 aaaaggcggg agcgtgacat tgccggaatc gggaacggat ttgttgacgc accgcttgga 726301 aaaggcgggg agactggcgg tcggaccgca tgaataccgt gtgattcaat ttgacaatca 726361 cagctgattc tttgtatcga atcagctttt ttctatggag ggagagacag atgaaaaaga 726421 tcaaatggtt atcaggacag ccaaaggtga caagcggcgt gacgtggggc atgccatgga 726481 aaaaaggaga attaaaaaaa ggagaccgtc tggcgcttat gaatgaaaac gcggaaacgc 726541 gatatgtgca aagcgaaccg tcggcctatt ggccggacgg gagcatcaag tggacgaagc 726601 acgcggcggt gtttggcggt caggaaaacc aaagctttac agtgcacaaa agagaagtgc 726661 cgcagccaac tgaatcgctc agcattcttg agacagagca tgatatccaa gtggatacag 726721 gagcactcgt ttgtaccatt cataaaacag gatctgattt cattcaatca ttgcagatca 726781 atggaaagcc gatcgccgca ggcgggaggc tcgttgcgat aagagaaacg agaaaagagt 726841 cagcggcgaa aatggttctt ttgcatgaaa ggtctgtcag ctttatcaaa cgggcggcga 726901 ttgagcagag tggtcctgtc aaagcagtag tcaaaatcga gggagtgcat gtgcttcata 726961 aaacgtatga ggaatggctg ccgtttgtca tccgattaac gttttatgcc gggctgtctg 727021 agatcggcct tgtgcacacg cagctgattg acaggagcgg taaactagaa ttcgttaagg 727081 ggctcggcat cgaattcgac ctttttttgg agggagagcc gtacaaccgc catttccgct 727141 ttgcgggaga gaaagggatg tataaagaac ccgcccagct gtttggcaca cgtaaattca 727201 atgaacgata tccgctttat gaaaaacaaa tcaatggcga aatgctgtct ccagatgaag 727261 agcataagga atggtttgca catggcacac agaatgcggt ttgggacgat gtcaagatcg 727321 tgcaagattc cagcgatcat tacagcctgt caaaacggac cggaaaagat tatgcgtggg 727381 ttggaatgct gcatggcagc cgggcgaagg ggctctgcta tgcgggcgga aaaaatggcg 727441 gtgtggctct cggcctgcgg tatttctttg agaaatatcc ttcagcactg gaaatcacag 727501 gtcttgccgg cagccgcccc aaaatgacta tctggctttg gcctccggac ggcgaagcga 727561 tggatttgcg gcattataca ggaaacactc acgtggccag cgcgtatgaa ggctttgatg 727621 aaatgcgctc tgatccgaca ggcattgcga acacaaatga aataagcctg gcgtgctttt 727681 cgcacatgcc gtctgacgaa gtcctcaatg cgctggctga caaatggcag gcgcccccgc 727741 tcattgtatg cgagccggac gtctattacg aatcaaaagc actcggggta tggagcatca 727801 ttgacacatc ccatccgctc aaaaaagagc tggaagaaca gcttgatgcg gcctttctgt 727861 tttataaaaa ggaagtagag caacgcagat ggtacggttt ttggcattat ggcgatgtca 727921 tgcatacgta tgacccgatc cggcatatgt ggcggtacga tctcggcgga tacgcatggc 727981 aaaacaatga gctcgttccg accctatggc tgtggcaggc gtttttccgc tcaggcagag 728041 aggatatctt ccgaatggca gaagccatga cccgccatac gagtgaaacg gacagctttc 728101 acctcggtga atatgccggg cttggctcac ggcataatgt tgtgcactgg ggatgcggct 728161 gcaaggaagc gagaatcagc atggccgggc ttcataaatt ctattattat ctgacgggtg 728221 atgaccggac gggagatctt ttgacagaag tgaaggatgc cgattatgcc cttgtcaaaa 728281 ccgatccgat gcgcgctttt tacgagaaag gcaagcaccc gactcacgcc agaacgggac 728341 cggactgggc ggcgttttgc tcgaactggc tggcggaatg ggagcggacc gaaaattcgg 728401 aatatctcaa aaaaatcgaa acgggaatca actgtctgaa gcggctgccg ctccgcttat 728461 tatctggccc gacatttgaa tatgatccgg cgacctcgat gcttcatcat atgggagacg 728521 gcattgcggg cggatatcat atgatcattg ccttcggcgc gccgcaagtg tggatggagc 728581 tggctgagct tcttgatgac tgggaatggg aggatatgct gagtgaattc ggcgaatttt 728641 acacactcag tgatgaggaa aaacgaaaaa aaagcggagg cgctcttcat gacgggcatt 728701 ttcactggcc gatgttcgcc gccggtatga cagcctacgc cgcaagaaaa aagcaagatc 728761 ctcatctcgc cgccaaagcg tggaatcttt tgctagaaga taagctcagc catacgccgc 728821 ttccgatcaa accggagcgc atcgagacat ggacgcagct agaggagctt ccatgggtga 728881 caacgaacac tgtctctcaa tggtgtttaa atgtcatagc ggcgctggaa ctgatcggag 728941 attcccttcc ggcaaaaaaa gaaacatcgg gcaaaaaagg ataacagccg gaatttcata 729001 ggagaaatgg tgcaaaaaat gaagattgca agaatttatg taagcgcttt atattgagag 729061 gggcaaaggg gaaatgcaaa ttgaaaaaag ggggacttac gcaacatgaa aataagaatg 729121 cgaaaaaaat ggatggcctt gccgcttgct gccatgatga tcgccggatg cagccattcg 729181 gaaacatcca attcagcaag cggttcgaaa gatacgatca aaattatggc gccgctctta 729241 tcgccggaaa gcccaagtga taagagccct tcattaaaag cgctcgaaaa atacacaggc 729301 aaagagatta aggtcacatg ggtgcctgat tcatcctaca acgacaaatt caacatcgtc 729361 atggcttcag gagagatgcc tcacgcgatt gtcattaaag ataagtcagc cggctttatc 729421 aaatctgtca aagcaggggc gttttgggag ctgtctcctt atttaaaaga ctacaagaat 729481 ttaagccagg cagatgaaaa gattttgaag aacagctcgg tgaacggcga ggtgtacgga 729541 atctacagaa cgagggatct gatcagggcg tgtatgatca tcagaaccga ctggctgaaa 729601 aatgtcggtc tggatatgcc ggaaacgctt gatgatttct atgaagtgct gaaagccttt 729661 aaggaaaaag atcctgacgg aaacggcaag gatgatacgt acggcatggt cgtgccgaaa 729721 tggatgggac tcggcaacgg aagcccatgg gatgttctgc aaatctggtt cggcgctccg 729781 aaccgctacg gtgttgaaaa cggaaagctg attccagatt ttacaacgaa ggaatacatg 729841 gatgcgctca cgttttttaa aaagctctat gatgagggct tgatcaataa ggactttgct 729901 gtcatggatt ctgcgaagtg gaatgatccg gttgtaaaag gaaaagcggg tgtcatcgtt 729961 gatacaggct caagagcgtc tcaaatccaa agcgcgatgg aggaggcgga tgagtcgaac 730021 aaggatatca ttgatatcgt cggctcgctt gagggaccga atggcaagcg caccttcccg 730081 acatctggtt attcaggcat gatcacgata ccaaaatcaa gcgtcaaaac cgaaaaagag 730141 ctgaaagagg tgctgtcctt cctcgataag atgaatgata aggaagcgca gattctcacg 730201 aacaacggag tgaagggccg caattacgag ctcaaggacg gcgtattcac ctcacttgaa 730261 aaaaacaata aatctctcct gtatgagcat gaaggcttgg cacagttcag catgtcgatt 730321 ccgaaaagcg agtattacat cgaagaccag aaaaccaagc tcttccagca tcgcaaggac 730381 atcataaccg aaggagaaaa aatagccgtc tttaaccctg ctgagtcgct tgtatctgat 730441 gtctataccc aaaaaggagc ccagcttgac aacatcatcc tcgacgcgag aacacaattt 730501 atcattggag aaattgatga aaaagggttc gatgatgcgg tggagctttg gaaaaaaagc 730561 ggcggcaatg aactgatgaa ggacttgaac aaattgtacc aatcgtcaaa ataaaccgat 730621 gcgcctgcct ttcggcgggc gccccggtat cacgaaagga gaacagatat ggaaacagtg 730681 ccgaagaaga gagatgcacc tgttctcacc gctggaaaag gcatcagctg gatggctgcg 730741 ctcaaacggg acaaatggct ttatcttctt cttattcccg gtctgcttta tttcttgatt 730801 ttcaaatact tgccgatgtg gggtgtgctg atcgctttta aagactattc gccatatctc 730861 ggcttctgga aaagcgaatg ggtcggcttt gattatttca aagacttttt tatgaatccg 730921 gattttttcc ggctgctgcg caacaccctc atgctggcga gtctggatct tttgtttgcc 730981 tttcccgcgc ctctcatttt ggctctgctt ttgaatgagg taagaaaggc cgtgtataaa 731041 agatgtatcc aaacctttat ttacgtaccc cattttgtat catggacaat tgtggtcagc 731101 atcaccttcg ttttctttac tgtcgataca ggtgtgatca acaaattgat tatgagcctg 731161 acaggtgagc agatttcttt cttgtcggat gcagactggt tccggccaat gattgtgatg 731221 caaagcattt ggaaggagac aggctgggga acgattctat ttttggcagc gcttgctacg 731281 gttgatcaag agcagtatga agcggccatc atggacggag cggggcggtt caggagaatg 731341 tggcatatta cgctgccggc gattagaagc accattatcg ttttgttgat tttaagaatc 731401 ggcagctttt tgaatcttgg ctttgaacag gtgtatttga tgacgaactc actcaaccgc 731461 agtgtggctg acatcttcga cacgtatgtg tacatgatgg ggattaccca aggggcgtat 731521 agctacagca cggcggtcgg tttgtttaaa tcagttgtcg ggattatctt gatttttggc 731581 gccaattaca ttgcgaaaaa gtttgatcag gaaggattgt tttagaggag ggagaggtat 731641 ggctgaaatt cacacgatgc acaacaccaa agccggacgg gtgtttgacg tctgcaacat 731701 tctgtttctc ggcggtgtcg gcgcgattac cattttgccg tttttatata ttatcgccgg 731761 ttcctttgcg acagaagcgg aactcgccca gcggagcttc tttattttcc cgaaaacctt 731821 tacacttgat gcttacaagt atgtgttttc gacaccgacg ttccttcgaa gcatgggcgt 731881 gtccatcttc atcacggtgg ttgggacggc tgtacagctg ttttttacct tcacgatggc 731941 gtatccgctg gcgaaacggc atgtgaaggg acggaatctg ctgttgaatc tggtgatttt 732001 ctccatgctg ttttcaggcg gcatgattcc gacgtacctt gtcgtaaaat cacttggcct 732061 tttggatacg tattgggcat tgattctgcc gatggcgatt aatccgttca accttattat 732121 tatcaaaaac ttctttcagc agctgccgcg cgagctggag gaatcagcaa aaattgacgg 732181 ctgttccgaa atcggcgtct tctggcggat cgccctgcct ctgtcaaagc cagttattgc 732241 gacctttgcg ctgttttatg cggtcgggat ttggaatgat ttcttccacg ctctcttata 732301 tatcaatgac agtgcaaaat ggccgctgca aatggtgctt cgccaagtca caattttatc 732361 ggatttaacg gcgaccaatg gtgatacgat gcaaaatgca gttccgccgg agcagggaat 732421 taaactcgct gtcattgtca ttgcgacgct gccgattttg gcggtctatc catttttaca 732481 aaaacacttt gcaaaaggaa tgctgatcgg ttcggtgaaa ggctgagaaa gggagtgttt 732541 catatcagta cattagatca gattaagatt gcctatatcg gcggggggtc ccaaggctgg 732601 gccagaagcc tgatgagtga tttgtcgatt gatgaacgga tgtcaggcac ggtggcgctc 732661 tatgatcttg attttgaagc cgctcagaaa aatgaagtga tcggcaatca cagcgggaac 732721 ggcagatgga gatatgaggc tgtttctact ttgaaaaagg cgttatcagc cgcggatatc 732781 gtcattattt ccattttgcc gggatcactg gatgatatgg aagtcgatgt gcacttgcct 732841 gagcgctgcg gtatttatca gtctgtaggt gatactgtcg ggcctggagg gatcatcagg 732901 ggcttgcgtg ctgtgccgat atttgcggaa attgcccggg caataagaga ctacgcacct 732961 gaatcatggg tcattaatta tacaaacccg atgtctgtct gtacaagagt gctgtataaa 733021 gtgtttcccg gcatcaaagc gattggctgc tgccacgagg tattcgggac gcaaaagcta 733081 ttggcggaaa tggtcacgga aaggctgggg attgaggtgc cgcggcgtga ggatatccgc 733141 gttaatgtgc tcggcattaa ccattttaca tggatcacaa aagcctctta ccgccatatt 733201 gacctgttgc ctatattccg tgaattcagc gcgcactatg gggaatcagg atatgagctg 733261 gagggggaat gctggaggga cagcgtcttt tgttcggcac accgtgttgc gtttgattta 733321 tttgaaacgt atggcgccat ccctgctgcg ggtgacaggc atctggcaga gtttcttccc 733381 ggcccatacc tcaaacagcc tgaagtatgg aaatttcatc tcacacctat atcattcaga 733441 aaacaagaca gagctgagaa acgacaagaa acagaacggt tgatcgtgca acaacggggc 733501 gttgctgaga aagcttcggg agaagaaggc gtgaacatca tagcggctct tctcggattg 733561 ggtgaactcg tcacaaatgt aaatatgccg aatcaaggcc aggtcttaaa ccttcctata 733621 caagccattg tcgaaacaaa cgcattcatc acaaggaacc gtgtccagcc gattttgtcc 733681 ggagcgcttc cgaaaggtgt ggaaatgctg gcggctaggc atatatccaa tcaggaggca 733741 gtggcggacg caggtttaac aaaggatact ggcctcgcgt ttcaagcctt cctcaatgac 733801 ccgcttgtcc agattgaccg cagtgatgca gagcagcttt tcaatgacat gctccaatgc 733861 atcatgcaaa gctgagcttg ccgattagct ctttccggtt tagaaaggaa agcattgacc 733921 atactgatag tataatcaag aagtaggtgc tatcaatatg ggaaattatt taagtgttgc 733981 ggtagaactg gtctgcggtt taggcatttt atttatcatc ttaaagcttc tcgggaaaac 734041 ccaattttct caaattacgc cgtttgactt tatttctgct ttaattttag gtgaattggt 734101 cggaaatgcc gtctacgatc atgaaatcaa aatcaaagaa attatttttg cttcgctatt 734161 gtggggcgtg ctgatttata ttattgaatt tatcacgcaa aaaatgaaat catcgcgaaa 734221 gttcttggag ggcgagccga atatcgtcat ccgcaaaggg gagcttcaat ataaagtaat 734281 gaagaaaaat aagatagaca ttaaccagct gcaaagccta ttgaggcaag ctgggagctt 734341 ttcgatccaa gaagtagaat atgcgattct tgaaacaaac gggatggtca gcgtgcttcc 734401 aaaatcagac tttgacaaac cgacaaataa ggatttgcag attccttcga agtccgtttc 734461 tctgccgatc acgttaatca tagatggaga gattgtgcgg gataatttga aggaagcagg 734521 tgtggatgaa cagtggctga aacaagaatt gaaaaagaag aacattgata agacagagga 734581 cgtgttattt gcagaatggc ataaaaataa gccgctgtat actgtaacgt acgaacaaag 734641 cagatcaaca tgactcttag aaaaaagctt gcagcaaggc gcaagctttt tattgattgt 734701 atgtcccttg tttgacagca cgtacatggt acatgctcac ttcagtgctg atcagatagt 734761 caggctttgg tttgcctttg tttgctttat ggccggcgat atgcgcatcg cttttttccc 734821 attgcttcca gtgatcctct gattcccagc gaatcatgac aacaacttct tcatcaccgc 734881 ggcgcacatt tttctcaagc actgtcacat caattaaacc ttcttgtttt tcaatgattc 734941 cttcagcgct gaaacgttct atgactttat ctgcaaagcc ttctttaacc gtcatttttc 735001 tcaactgtac aaacatttgt ctcactccaa tcattctcac atatgaataa ttgtaaatga 735061 aattcattct caatgtcaaa gaaagcgcag ggcggaatcg aaccgccgtg cgcaacagtt 735121 tattctttta ataaaaacac atttccgtct tcgtccttaa attgaacgaa ggtgccccac 735181 tccatttgat tgggctcacc gagaaattct acaccgtttg tcttcatttt ctcgtatgta 735241 ccaaagatgt cttcgcattc aaacacaata gaagccttca tttgctctga gcctttcatc 735301 atggctttcg ggtaaatgac taaacgagtc tcggctcctt ttggcgcaac ctccagccag 735361 cttgcttcag gtcccattgg gtgatccgct gcaatatcaa agcctacctt ctctgtccaa 735421 aattgcttcg ctttctgctg gtcctcgaca tatacagcaa cagtgccaat ttgtttgatc 735481 atagggaaac ctccaagttg aaaagataat aatactataa cctgtttacg gccgaagtaa 735541 cataaaaaaa tcagccggga aaccggctga ttattaaaat gagcagctta caacatcgat 735601 gtgatttgtg tctaaggcga aataaaccca gcggcgccgt gaggaatccc aataaaagcc 735661 gccgacggat cttctgccaa ggatgatcgg gtaaaaccaa aatgagcggc cattggttaa 735721 ccagacatag gtaaatcgga aaaggcaagg acgaatggtg attggttcaa ctaacaaaac 735781 ggctccttga gaaccctgcg gttttggggg tttcgctggt atttgggaag gaggaggtcc 735841 ctgcggcgca ccgccgaagc ctgggctggc accgctgcca ataccagggc cggagccgcc 735901 gccaaagcct ggaacagcac caccgccaat gccaggaccg gagccgccgc cagagcccgg 735961 aacagcgccg ctgccaatgc caggccatgg atatcggtat tcatattcaa aagcaggcca 736021 aggctcataa aaatgccccg caaacatata aggatcaaca taatacatgt gataacgtcc 736081 tttctcattg taaactgtac attgcagttt atgcgggcgg actcttattg gtgcattcgc 736141 ctaaggatat gaagctggaa tgctctcaga gagcagaatc atttgatttt tctctagtct 736201 tattcacaat tccgatttat cattttataa tgaaagtgct tctattacga aaaaggagac 736261 agaccgtgaa tatcgatcaa ttattatatc aatatatcat agacaacact gcggatatta 736321 ctgagaaatg gttcagtttg cgttgccagc taaaaggcga gctatattcc gccagccatt 736381 taagtgaaga aacgaaaaca cttttaaccg agcagcatac atttaccaat ataacaatcg 736441 caagcgcatt tctggaggat caaaccgatt ttcaagaaaa catgacaaaa tgggcgcaaa 736501 acgttgcgaa aaacagggta gagcaggatg ttcaagtgca tgaggtcgta gaagccatat 736561 ccaattcaag aatctcattc tgggacgcag tcgccacatt tataaaagag aatcaggaga 736621 ttgtgacaaa tgaggatgca gaccgatgga accgcattgt gaatcagtcg ttcgataagc 736681 tgattattga attctccgag cagtaccaaa aattcatgct gatgaggctt acatctcagc 736741 aggaactgat ctcagagctt ggctgcccgg tcatttccat tgccgatgga atcgggatat 736801 tgccgcttat cggctccatt gatacaaaac ggcacaggtc attttagaaa cagtgccggt 736861 ccgctgtgtc gagagaaaaa tcacaagcct cgtcgttgat ctttcgggtg ttccgattgt 736921 ggataccatg gtggctcagc aattgtacaa cctgtctaaa acacttttct tattaggcgt 736981 caaagccgta ttttcaggaa ttcgcccgga tgtggcccaa acatcgattc aattggggct 737041 tgattttagt gaatatgaaa cgtacggcac gctgaagcag gcattagaaa acatgggtgt 737101 ccgctgtatt gttgaggaat tggaagaaaa caaataggaa gtttccaggc atatgattgt 737161 ccgtcaccgg gtgatcatat gcctttttga tttgaacaga aatcaccatt gatttatcga 737221 aaaaaacata atattataat tcttataaga atactgtgaa ttaaaaccta ttcaacaggg 737281 gggaaggtct tttggtttct aaatcaacga ttgatccgga agtgattgaa aaaatcatca 737341 gctcgctgga aacactcgat ttcggcacgg ttcagattac ggttcatgat tctcagatta 737401 cccaaattga gaaaatagaa aagcaccgtt tttcgctgaa aaggaaagaa tcaaaatgat 737461 aatgtaaagg gcgtttgttt tcattaaatt ctccttaaaa catatacata tttcatccaa 737521 tttttatata atagaccttt aagatcattt tttaggagga tttttgacat gcaagctacg 737581 gttcacgaga gtaagcaatc gatcatgcaa cgcattttga cagtctttgt cttcacattg 737641 ctgatcgcga ctgtcggcct ttttatcggc caatttgttc ctgtcgcttt gatgctgccg 737701 ctttctattc ttgaagtggc gatgattatt ctggccttct ggatgcgcag aagaaaagcg 737761 gtcgggtatg cgtttgtata tacattcgcg ttcgtttccg gcattacctt atttccgatc 737821 gtcagccatt acgcttccat cgccggcgcc tatgtcgtgc tcgaagcctt tggctctaca 737881 tttgtcattt ttgccgtctt gggcacaatc ggcgcaaaaa tgaagaagga tttatccttc 737941 ctgtggtcgt ttctgctggt tgcggtgctc gcactcgcag tggtagggat tttcaacatt 738001 ttcagcccgt taaactcagc ggcgatgatg gcgtattccg tgatcggaac catcgtcttt 738061 tccctttaca ttttgtatga tttgaaccaa atcaagcacc gccacattac ggaagacttg 738121 attccggtta tggcgttatc gctgtaccta gactttatca acttgttcat caacctgctc 738181 cgcttcttcg gcattttgag cagtgatgat taatgaaaaa gcgtctgtca ttggataggc 738241 gctttttgcc atacatcaaa aaggcaggtg gagtattggt gaaaaaacaa atgggcgcat 738301 atgtatctct ggcagcagct atggcgatcg tcggcagttc tgtcgttgtc ggcaagctga 738361 tggtcgaacg gattccggtc tttctttcct caggattgcg ttttttgatc gcttctgtcg 738421 tattgctcat gctgctgttt tgcattgaaa aagggtttcc ggctttgacg aaaaaagatg 738481 tgttcgtatt actggtgcaa tcattcacag gcgtgttttt gttcagtatt tgcctgctgt 738541 atggggttca atatacgacg ggaacggaaa gcggcatttt gacaagcaca acccccatgt 738601 tgatcggtat tttatccttt ttcctgctga gagaaaaaat tgagaaaaag acgctgatcg 738661 gcattttgct ggcggtttgc ggcgtaatgg cgattaattt gtttggagcc gggagccaag 738721 acgggacgcc gcacgcctta ttcgggaaca tgctgatcat tgctgcagtc attggcgaag 738781 cgttgtttac attgatggcc aagctgctat ccccgcatat ttcggcactg gcgatttcga 738841 ccttcgtatc gctcttcggc ttcctgtttt ttctcccgtt tgctttgttt gaggcctctt 738901 catttgatta cagcgtgccg actgttttgg attggtcgta tgtgctgtat tacgcgcttt 738961 ttgtcactgt tttggcgttt tacttatggt atagcggggt gacgaaggtg ccggcgggtg 739021 tatcgggcat tttcacatcc gttcttccgg tctcagctgt cattttgtca ggcgtgatat 739081 tgaaggagcc atttgagttt gtgcatttca tcggcattgc atgtgtcatc ggcggcatat 739141 ttgttacggt cataaagaaa aaacagccgg atgcgtatcc ggctgcagaa gaaaagacgc 739201 tatagcctgt ccggatcgga cgggtttttt agtctttaaa cacgctcagc ctttcaaaaa 739261 gatcaccaag catcttcacg aacatgtctt tttcctcgtc gctgtagttt tccatgacag 739321 cggatatttt gctgaaatgg ccgggcagaa attgctccag gcgtgctttg ccttctgttg 739381 tcagttcaat gctgattttt cgtttatcct ctgtgtgatg cctgcggctg acaaaaccgt 739441 ctctcgccag cccgtctagc aggcctgtaa ttgttgcttt cgtgacattt gaccgcttgg 739501 caagctctgt cggacttaac ctatgatcct tggcatcaaa gagcagcatc aggattttga 739561 attttccttc tgaaagccct cggccagcaa agtaatgctc catcacatga ttcatttttt 739621 ttgaaatatc aaaaagagat aaaaacaatt caagagagcc ggcgtcaata ttggcatacg 739681 tttcggcgtg ctctgttata tgcttatatt tcggtaaatg ttttaattcc atcgcaatta 739741 gctcccgtac attcgttgtg acacgattat aaaggaggga aaaccataac gcaacttggc 739801 ttggagatga ttgacagctt ttcttgggac atagtaaggt aatatagtta ggcgcctaac 739861 taatacatat agagctgaaa aggtggttat tgatatgaaa catatgttaa tagcaggagg 739921 cggaatcggc ggcttgtcag cggccatttc tctccgtaag gcagggtttt ccgtcacctt 739981 atgtgaagcg gcttcagaaa atcgaaaaac aggtgcgggg attcttcagc cgcaaaacgc 740041 actggcggtg ttgaaagaac tgggcgtatt cgaagattgc tgtaagcacg gctttcaaac 740101 agaatggttt aaaacgtttg atgaacaggg gaatttgctg tttcaagtca gtgaatcctt 740161 tttagacgat tcacttccgg gacgcaataa tatcctgcgc aaaacgttaa atgacattct 740221 catgaagcat gccgaggcag tgggtgtaga catcaagtgg gggaaaaagg ttgtcgccta 740281 tgaagaaact gctgaatcgg tcactgcctt atgtgaagat ggagaaaaga tgcaggctga 740341 cattctggcg ggctttgacg gcattcactc cgttgttcgt gataagatgc tgcaaaagga 740401 aacggaaaaa gagcatctcg gcatgggagc gtggcgcttt tatatcgaac ttcctgatta 740461 cacattcgag gacgcaacat tcatgtatag aagcggagac acacaaatcg gggtggtgcc 740521 attggcacaa cacgctggct atgtcttcgt cctccagcct tgcacgagcg attactggga 740581 tgaggaagat acccggtttg atagagtaaa agagattctt tctggttttc gggggctgga 740641 ttttgtcaca aagcacatgt caaaacagca tcctgtcatc tttaacaaac tggagcaggt 740701 cgccgtgcag gagccatggc ataaaggccg cgtcatcatc ggaggagacg ccgcccacgc 740761 cggtgcgcca accctggcac aaggagcggc aatggcgatc gaggatgcca tcgtcctcgc 740821 cgaagaactc caaaaccacg ccgaccacga aacagcatta caggcgtact ataaaagaag 740881 agccccacga gcgctcaaag tccagaacct atcatctgaa atcgtccgcc gcaggctgaa 740941 aggagagccg ggagcggaag aactgattgg ggagtgctat gcggtgttga gggaagggta 741001 ttaaatagga aaagtccaga aagtgatttc tggacttttt agtcttgctc tgttttattc 741061 cttatccgct caatcacctc atgcagcccc tcaggcttat aaaactccac cggtgaactg 741121 cctttctcaa acgaaatcgt ctcggcttca atcagcgcga catagcgccc gtttactttt 741181 gcgagatgaa tagaatcgcc aaaatccgct agcaatccct taatctctgt ttctccgact 741241 ttcattttca gctgggcctc tggcgtgtgc tcgatgattt gggcggaggc ttcgatgact 741301 tgatgggtgt cgaggcgctc ttggatttcc cgtttttcgc ttgcttccca aatctcaatg 741361 tcgtgctcga actgcttgag ttcttcgctg ttgtcttcaa atgtctcgta gacgtgctct 741421 tgtaccatgt tcatgacctg atttttcatg atttctggca tcgattctcc gtactcgacg 741481 aatttcagaa agtcctcaaa atagcgggcg tgcgaggcct ggtggatttt cagttcacct 741541 tcctcgacca ttccttcctc tggcatgtac gggtattgga tgcttttcat gttttttgtc 741601 gtgatcgcca tttcgacttt tttaatgaga gaagacgcgt cagagatgcg ggcgaccttc 741661 ggctcaaaat cacatttcat aatgaagaca aatgactcat caaagtattt tctcggcacg 741721 gccgaagcga cgagaaacac gccgccgcga accgcgcttg tgtcaaggta cgtgcggacg 741781 aactgctcgc tcagctcatt gaagtcttct tttgtttccg ccagacgcgc gcggttgaac 741841 atgttgtagt ttgggttgga atcgagctcg tggccgggct cgacgataaa atggccgatt 741901 ttcgtcggca cctgctcgga ctgcggatgg cggtcggctt tccgtttaac gatttttttc 741961 agttccccgt cgagaaagtc cttcagctcg ctttcttcaa attctcccgt atcaagggtc 742021 tggaagtgct tgaactgctt gttcgcctgc tcatctttgc cttccacctg tatgacataa 742081 aaggataaaa accgaatttc aaaatccata tataaactca ccttattcgc gtattgtaca 742141 gcttctcaag tatagaaaaa acagcgatca tgcgtcaatt gggagaacgg aataatcatg 742201 accatgaaag ggaaatgtag tcaaatagaa ggcatttcat acggaaagga atggttcgat 742261 gaaggaaaca agcccgattc ctcagccgaa gacgtttggg ccgctcggca atttgccttt 742321 aattgataaa gacaaaccga cgctttcgct gatcaaactg gcggaagaac agggcccgat 742381 ttttcaaatc catacacccg cgggcacgac cattgtagtg tccggccatg aattggtgaa 742441 agaggtttgt gatgaagaac ggtttgataa aagcattgaa ggcgccttgg aaaaggttcg 742501 cgcattttcc ggtgacggat tgtttacgag ctggacgcat gagcctaact ggagaaaagc 742561 gcacaacatt ctgatgccga cgttcagcca gcgggccatg aaggactatc atgagaaaat 742621 ggtcgatatc gctgttcagc tcattcaaaa atgggcaagg ctcaacccga atgaagcagt 742681 cgatgtcccg ggagatatga cccggctgac gctcgacacc attgggctat gcgggtttaa 742741 ctaccgcttt aacagttact acagagaaac gccccacccg tttatcaaca gcatggtgcg 742801 ggcgcttgat gaagcgatgc atcaaatgca gcggcttgat gttcaagata agcttatggt 742861 cagaacaaag cggcaattcc gctatgatat tcaaacgatg ttttcgttag tcgacagcat 742921 tattgcagag cgcagggcga atggagacca ggatgaaaaa gatttgctcg cccgcatgct 742981 gaatgtggaa gatccggaaa ctggtgaaaa gctcgacgac gaaaatatcc gctttcagat 743041 catcacgttt ttgattgccg gccatgaaac aacgagcggc ctgctttcct ttgcgactta 743101 ctttttattg aagcatcctg acaaactgaa aaaggcgtat gaagaggtcg atcgggtgct 743161 gacggatgca gcgccgacct ataaacaagt gctggagctt acatacatac ggatgatttt 743221 aaatgaatca ctgcgcttat ggccgacagc tccggctttc agcctttatc caaaagaaga 743281 cacagtcatt ggcggaaaat ttccgatcac gacgaatgac agaatttctg tgctgattcc 743341 gcagcttcat cgtgatcgag acgcttgggg aaaggacgca gaagaattcc ggccggaacg 743401 gtttgagcat caggaccaag tgcctcatca tgcgtacaaa ccattcggaa atggacaacg 743461 ggcctgtatc ggcatgcagt ttgcccttca tgaagccaca cttgtgttag gcatgattct 743521 aaaatatttc acattgattg atcatgagaa ttatgagctt gatatcaaac aaaccttaac 743581 acttaagccg ggcgattttc acatcagtgt tcaaagccgt catcaggaag ccattcatgc 743641 agacgtccag gcagctgaaa aagccgcgcc tgatgagcaa aaggagaaaa cggaagcaaa 743701 gggtgcatcg gtcatcggtc ttaacaaccg cccgcttctc gtgctgtacg gctcagatac 743761 cggcaccgca gaaggcgtcg cccgggagct tgctgatact gccagtcttc acggcgtaag 743821 gacaaagaca gcacctctga acgaccggat tggaaagctg ccgaaagagg gagcggttgt 743881 cattgtgacc tcgtcttata atggaaagcc gccaagcaat gccggacaat tcgtgcagtg 743941 gcttcaagaa atcaaaccgg gtgagcttga gggcgtccat tacgcggtat ttggctgcgg 744001 cgaccacaac tgggcgagca cgtatcaata cgtgccgaga ttcattgatg agcagcttgc 744061 ggagaaaggc gcgactcggt tttctgcgcg cggggaaggg gatgtgagcg gtgattttga 744121 agggcagctt gacgagtgga aaaaaagcat gtgggcggat gccatcaaag cattcggact 744181 tgagcttaat gaaaacgctg ataaggaacg aagcacgctg agccttcagt ttgtcagagg 744241 gctgggcgag tctccgctcg ctagatcgta cgaagcctct cacgcatcca ttgccgaaaa 744301 tcgtgaactc cagtccgcag acagcgatcg aagcactcgc catatcgaaa ttgcattgcc 744361 gccggatgtt gaatatcaag agggcgacca tcttggcgta ttgccaaaaa acagccaaac 744421 caatgtcagc cggattcttc acagattcgg tctgaaggga accgaccaag tgacattgtc 744481 ggcaagcggc cgcagtgcgg ggcatctgcc attgggccgt cctgtcagcc tgcatgatct 744541 tctcagctac agcgtcgagg tgcaggaagc agccacaaga gcgcaaatac gtgaactggc 744601 gtcatttaca gtgtgtccgc cgcataggcg cgaattagaa gaactgtcag cagagggtgt 744661 ttatcaggag caaatattga aaaaacgaat ttccatgctg gatctgcttg aaaagtatga 744721 agcgtgtgac atgccgtttg aacgattttt agagctttta cggccgttaa aaccgagata 744781 ctattcgatt tcaagctctc caagagtgaa tccgcggcaa gcatcgatca cagtcggtgt 744841 cgtgcgcggc ccggcgtgga gcggccgtgg cgaatacagg ggtgtggcat caaatgattt 744901 agctgagcgt caagccggtg atgatgtcgt gatgtttatc cgcacaccgg aatcccggtt 744961 tcagcttccg aaagaccctg aaacgccaat tattatggtc gggccaggca cgggagtcgc 745021 gccatttcgc ggtttccttc aagcccgcga tgttttaaag cgggagggca aaacgctcgg 745081 tgaggctcat ctctattttg gatgcaggaa cgatcgggat tttatttacc gagatgagct 745141 tgagcggttt gaaaaagacg gaatcgtcac tgtccacaca gccttttccc gaaaagaggg 745201 catgccgaaa acatatgtcc agcatctcat ggctgaccaa gcagatacat taatatcaat 745261 ccttgaccgc ggtggcaggc tttatgtatg cggtgatggc agcaaaatgg ccccggatgt 745321 ggaggcggca cttcaaaaag cgtatcaggc tgtccatgga accggggaac aagaagcgca 745381 aaactggctg agacatctgc aggataccgg tatgtacgct aaggatgtct gggcagggat 745441 atagataaag aagactggag acatccagtc tttttagtcc tttcgaaaaa atggtgatcg 745501 cgctaaacat tgatgcatac aataacttca gtccgccgga agggcgggct gtctgcaaaa 745561 cctatttttc gtttttgcta gtttatgtta ttcttatact cggtatctat ttcttttttc 745621 aaaggcacac atgacaaaag aaatcctttt tttatttccg agaaaaaaat gtgaaacgaa 745681 atgaaggttt ctttcgtcca gtgattggtt tccaaatggt tgtaataaaa atgatatggt 745741 gcgaaacata aatattccgg cttgccgcgg tgtatttatt gttgtgtgat gccttgattt 745801 tgtttggaaa gaaggaattg gaaggcagga tataaagagc aggtaaatat gaatgaagaa 745861 cttaaagtgt ttaagaaagt agaggttgcc atgaagaaac ttttttctta caaacttagc 745921 ttttttgtgc tggctgttat actgttttgg gcaaaaacgt atttatccta caagactgag 745981 tttaatcttg gggtaaaagg cacaactcag gagatcctcc tgatatttaa cccattctca 746041 agcgccgtct tctttttagg actggctttg ctggcgaaag ggcgtaaatc agccattatt 746101 atgctgatta tcgatttctt gatgacattt gtgttatatg caaatatttt attctatcgt 746161 ttctttgacg atttcttgac gttcccgaac attaaacagt ccggaaacgt tggaaacatg 746221 ggagacggga ttttcagtat catggccggt catgatattt tctatttctt agatattatc 746281 attttgattg cggtattgat ctggagacct gaattaaaag aatacaaaat gaaaaaacgc 746341 tttgcatctt tagtgatcct ttctgggatc gcactgtttt tcatcaacct gcactatgcg 746401 gaaaaagacc gtccgcaact gctgacaaga acgtttgacc gcaattatat tgtgaaatat 746461 ttaggtttat acaactacac catttatgac ggtgtacaga cggctcaaac agagacgcaa 746521 agagcctatg caagcagcga tgatttaaca agtgtcgaga attacacgac gtctcattat 746581 gcgaaaccaa acgccgagta cttcggctct gccaaaggca aaaatatcat taaaattcac 746641 ctcgaaagct tccagtcatt cctgattgac tacaagctaa acggtgaaga ggtgacgcct 746701 ttcttaaata aacttgcgca cggcggggaa gatgtgacgt attttgataa cttcttccat 746761 cagacaggcc agggaaaaac atctgatgcc gagctgacaa tggataactc gatcttcggt 746821 cttcctgaag gctccgcgtt tgtgacgaaa ggcgaaaaca cctaccagtc gcttcctgcg 746881 attttagacc agaaggaagg ctatacaagc gccgtcctgc atggtgatta caaatcgttc 746941 tggaaccgtg accagattta caaacatatc ggatatgaca agttcttcga cgcaagcacg 747001 tatgatatgt cagatgaaaa tgtgattaat atggggctta aggataagcc gttctttaca 747061 gaatcgattc caaagcttga atctcttaaa cagccatttt atgcgcattt gattacattg 747121 acaaaccatt atccgtttaa ccttgatgaa aaagacgcgt ctcttaaaaa agcgacaaca 747181 ggcgataaca cagttgacag ctacttccag acagcgcgtt accttgacga agcgcttgag 747241 caattcttca aggagctgaa ggaagccggc ctgtatgaca actcagtcat catgatttac 747301 ggtgaccata acggtatttc tgaaaaccat aaccgagcga tgaaagagat tcttggaaaa 747361 gagatcacag attatcaaaa cgcacagaac cagcgtgtgc cgctgatgat ccgcgttcct 747421 ggcaaaaaag gcggagtgaa ccatacgtat ggcggcgaaa ttgacgtcat gccgacactt 747481 ctgcacttag aaggaattga ttctcagaaa tatatcaact ttggtactga tttattctct 747541 aaagaccacg acgatacggt ggcattcaga aacggagact tcgtaacgcc gaagtacaca 747601 tcagtcgaca atatcattta cgatacgaag acaggtgaaa aactgaaagc gaatgaagaa 747661 acgaagaatc tgaaaacaag agtgaaccag cagctgagcc tttcagacag tgtcctgtac 747721 aaagacttgc tgaggttcca taaactaaat gatttcaaag ccgttgatcc gtcagactat 747781 cattacggca aggagaaaga aatcaaataa gatgaaaaag agccttgagc gggcgcattg 747841 ccttcgctca aggctctttt tttggttata caaccaactt gaaaaaatag attccatttg 747901 gtcaccaagg ctggctttct ctcatatcat tacagtagat tttgaaaccg gattgaaatc 747961 ggacaaatta tcggggaaat gccttgatag attgtgaaga tgtaccaggt ttcgaactca 748021 atattcatag agatgagggg tagagatgaa agcggtcatt ctctgcggcg gaaaaggaac 748081 gagaatgagt gaagtcacga atgacattcc taaaccgctc gccatgatag gcggcaaacc 748141 gattctatgg catattatga aaatttatca gtactacgga gtaaacgagt ttattctgct 748201 tttgggctat aaaggagaaa aaatcaagga atactttctc gactatgaat ggaagcacaa 748261 cagcctgaca ctcgacagct ctacgggaga ggtacagatg ctggggcagc ctgaaacgtg 748321 gaaaattacg tttttggaga ctggggtaga tacgctgaca gccggaagaa tcttgcaggc 748381 gaaagactat atcggtgatg aaacatttct gctcacctat ggagacgggc tggccaatat 748441 caatcttttc catctcatca gctatcatca gacaaaaggt gctgccgcga ctgtcaccgg 748501 cattgacaaa gtctcgcagt ttggcacctt gacagttgag gatggcatgg cgaaaacatt 748561 ttctgagaag acatcaagtg atggaatcat caacggcgga ttcttcgttc ttagtccaaa 748621 ggttttcgat tatttgccga aggacgggaa cacgatgttc gaagatgaac cgctgaagaa 748681 ccttgccaaa gatggggagc ttgctgtgta ccgccattac ggattttgga cggccatcga 748741 tacgtataaa aatctcttag aagtcaacaa aatgtggaat caaggacaac aagtatggaa 748801 ggtatggtga attgatttga gtttctggaa aaataaaaac gtatttgtca cgggatgcac 748861 aggtctttta ggaagctatt tggtgaaaga gctgatcgaa cagggcgcaa acgttacggg 748921 gctagtcagg gatcatgtgc ctcaatccaa tctttatcag ggagaacata tcaagaaaat 748981 gaacatcgtg cggggctctc ttgaggactt ggctgtgatt gaacgcgcgc ttggcgagta 749041 tgagatcgac acagtctttc atcttgctgc acaagcgatt gtcggcgtgg caaaccgcaa 749101 cccgatttct acctttgaag cgaatatcct cggcacctgg aatattctcg aagcctgccg 749161 caagcatccg ttaattaagc gggtcattgt cgcttcaagt gataaagctt acggcgatca 749221 agaaaacctt ccatacgatg aaaacatgcc gctgcaaggc aagcacccgt acgacgtctc 749281 aaaaagctgc gcagatctga tcagccacac ctattttcac acgtacgggc ttccggtctg 749341 cattacgcgc tgcggaaact tatacggcgg cggagatttg aacttcaacc gcatcattcc 749401 tcagacgatt cagcttgtgc tgaacgggga agcgccggaa atccgaagcg acggcacatt 749461 tgtacgggac tacttctata ttgaagacgc cgttcaggct tatctgcttc ttgcagaaaa 749521 aatggaagaa aacaatcttg ccggagaggc ctttaacttc agcaatgaga tccagctgac 749581 cgtacttgaa ctggtagaga aaatattaaa gaaaatgaac agtaatctga aacctaaggt 749641 gctgaatcag ggaagcaatg aaatcaaaca tcaatattta tccgcggaaa aagcaagaaa 749701 gctgctgaat tggacaccgg cctacactat tgatgaggga cttgaaaaaa cgattgagtg 749761 gtatacggaa ttcttcaaaa agtaatgtga aacgaggtga acaagactgt gaccagcgcg 749821 tattgcaccg ttttatcaaa aggaagatta tatcaggcag tcgctttgtt taagtcgtta 749881 gagcaagttg atcaagacag tcccattttt atactttgca tggatgaaga tacgcaccgc 749941 gtgttacaga agctgaagat gaagcagctg aaccttgtgc cggtggccgc tcttgaaaat 750001 gaattgctgc tgaagctgaa ggaaactaga gatcaaagtg agtattgctg gacgatgaag 750061 ccgatctttc tgcaagctgt gctgaacagc aatcctgagc tggagcgtgt gacgtatatt 750121 gacggggatc tctttttcta tgcagatcca tcgccgattt ttgaaaacca gccggactgc 750181 tcggtgttgc tttcacgagg ggatattgta atcccttctt ttgagaaaga gcagattgac 750241 atgctgcagc gtcttttagg cagatataat tccgggttta tcagcttcaa gcatgatgat 750301 gcaggcacgg attgcttgga gtggtggaag gaacgctgtc ttgaggaatg caaaaatgca 750361 ccgggtgaag ggaaattcgg tgatcagggc tatttggatt atatgtctga gctgtttccg 750421 aatgtgtgtg acattacaac acccggcgtg aacatcggcc attggaatta tggacagcat 750481 acgttttcct ggaaagatgg ccggatcgtg ctggaggatg gcagtccgct gatcttttat 750541 catttcagcg gataccgaat cgtcagcatc aatgaaatca aacagattca tgaaacaacc 750601 cgcacagatc tgccgtttgt gcatgaactg tatcaagaga cactgccgca tatcattcag 750661 cacatgcaaa cgttagaccc tgaatttaac ggttttgctt caaaagatga caacaaataa 750721 atgagtaaat acaggaagtg aaaatgaagt gaaagcaagc gttattattc ctgcatataa 750781 ttcgaaggag cgtctttaca acagccttct gtcattaaac cagcaggagt gcgatgaaga 750841 atttgaagtc attgtagcgg acaatggctc tgaggacggg acgctctcga tgcttgagtc 750901 atttcaagct gattttccgc tgatctttac acggattaaa gaaaacaggg gcattgcgta 750961 cggacgaaat caggcgcttc gcaatgccag aggagacatc ctgattttcc atgacagcga 751021 tatgcttgcg gcaaaggacc ttgtggcaaa acatattaaa gcccatgaga acgaagagaa 751081 tctcgtcgtg tgcgggttgt tttggaaacg gatctacagt ttttactatg aacgatttga 751141 agaagaacat aaggaacagc tcgcaaagct cacaggtgaa atgccgaaga aagacaaaca 751201 aaagctgctg gaggaagcgg acatcaaaaa cggaagcttt cttgataaaa gctttgacct 751261 cgataccgac tttatagacg tgctcaagaa gattttagat gagtacggcg atgacttgaa 751321 aggctatcat atgccatggc gcttttttat cacgaataat tcctctgtga aacgcaagca 751381 tgtggttgac ctcggtttat ttgacgaagg cattgtgcgg tacgggtttg aggattatga 751441 cctcgggatc aggcttcatc aggccggatt gaccttcagg cttcgccgtg atattgtcag 751501 tgttcatcag gaacatccaa gcaattgtaa gtctgtagac gatattcggg caaacattgc 751561 ctatatgtgc gataaataca ataacatccg ctccttagac gttcatctcg cttttaatgg 751621 gccgttcccg cctgacatga cgaacagaat catggctgat attcaaaagc tgctggaatc 751681 acagaaatat gatatgctgc tgaatctgtt tcttgagctt ctgcatgttg ttaaagagcg 751741 caacattgat ccggattggc gaaagaaatc cccaagggtg acggcgaaaa gctttgattt 751801 gcaaactgtc cgcaagcttc tgcctaaggc gaagaaaaag ctaggcgtga acgattttgc 751861 caacgcactg tatgcgcttg tcaacgattt gctgcacgtg gatcttagat cattggatgt 751921 ggtataagtg agtacatttc atttttcaac gatagtgtca aggacacata tctttaagct 751981 catgcctatg attcattctc tccatgagca ttgcgatgat tttcatttat atgtgctgtg 752041 tgtcgaccag aaagcgtatg aattgcttca gcacgttcca tgggagcatg taacctttgt 752101 gcagctgcat gaaatggaag acccggagct gttgaaagcg aaaagcaaca gaacgtttca 752161 tgaatattgc tggacgttaa agcccgcctt tttgtttcat gtgatgagca agtgggatga 752221 cgctgaatac tttgcccata tggatacgga tctatttttc ttttctgatc cggcacgtat 752281 ttttgcagaa aacccaacgg cgtctctgta tttgactgat catcgtaatt cgccgcgctt 752341 catgtcctac tacgaccgaa ccggacgctt taatacaggc tttgtcggcg ccggtaatac 752401 aaaggaagca tatgaagcgg tgtggcagtg gagacaggac tgtattgaat tttgcacggt 752461 cgaaatggat acggaacgaa agacatatgg tgatcaaaga tatgtggaga aatggccgga 752521 gcagtttaaa ggtgttcatg ttgtcaaatc cataggagcc aatacagcgc tttggaatat 752581 cgaaaactat aaggtcgggc aaaaggacgg ccgcgtgtat atagatgaaa cgccgctgat 752641 tttctatcat ttctctgggt ttacgctggt gacagaaaaa gagtttaatc tttgctggta 752701 ctaccggatt gaagacgaag cgacaattaa gatgatttat atgccctata tattaaatct 752761 gaaaagatgg attgatgaaa tacagtcggc gtttccggac tttgcggatg gctttatccc 752821 gaagcacgca gtgcctgaca ctcattttat ccagctggat taaaaaaccc cctgccgcct 752881 ggcaggggtt ttttcagcta tgccattctc tcagcttctg gtcacttggc aataggaagg 752941 caaggatgcc gaggacaggg agaaaggcaa tggcgatcat cgtcggggtc agtcccgcgg 753001 catcaatcag agcgcccagc gccacagcgc cgattgcgcc catcccgaag gcaagcccga 753061 cggttaaacc ggacattgtg ccgatttttc caggaactag ctcctgtgcg tagacgaccg 753121 ttacagaaaa gctcgacatc agaaccaagc caatcaatgc gagcacgccg taggcgagaa 753181 ccgggccggc aaatggcagc acaatcgcca gcggcgccga gcataacagc gaaccgagga 753241 taacgaagcg ttttccaaaa cggtctgcaa gcgggccgcc gagaaacgtg ccgatcgcgc 753301 cgaacagcaa gaagacaaaa atatagcttt gtgcctgctg aatgcttacg tgataggtat 753361 ccatcgcgta aaacgtgtaa aagttaccga tcgcactcgt ataccaagaa cgagcaaaaa 753421 tgagaaatat aataataata agagcagata caacagattt ggtgatggcc gtgttttcag 753481 ccgttttctt ttgcttgcct gatttctggg caaggctgcc gagacgtgag gcgtaccatt 753541 tcgcaatata catgagaaac ataacagcaa gcgcggcgac aagcgtgaac caaacagcgc 753601 cgaattgccc gagcggcaca aggatcagcg cggtgatcag cggtgccatc gcctggcctg 753661 agtttccgcc cacctgataa atcgattggg cgagcccgcg ttttgtgccg gcggccatat 753721 acgccacacg ggagccctcc ggatggaaaa tggccgagcc taatccaatg aaaaacacac 753781 agcataagat cgttatgaat gacggggcaa atgcaaggcc caaaatgcca agcatgctgg 753841 cggtcaaacc gactggcagc gcatacggcc gcggccgttt atcggtatac cagccgacaa 753901 caggctgcat gacggatgac accatgttta atgtgaaagc aatgatgccg agctgtgtaa 753961 acgtcaggct catggagcgt tccaaaatag ggaacatggc cggaatcaca gcctgaagcg 754021 aatcgttgag catatggcaa attccgataa taatcaaaat cggatacacc gtggtgcctg 754081 gtttttgaac tgttttttct tttaacgggg cggcgatagc cattgagtct cctccttaca 754141 tatataacca aagcatacca ccatattatt cataaggtga agaatttatc aagaggaaaa 754201 aagattctta tgaaagaaat accgtcagcc tgattagcag ctgacggtat tttcgatatt 754261 caaaatgtga tatagctctt caagcttacg aatctcatag gttggtatga tctctggcac 754321 attcggcttc atgtcagggt tcatccagca agtatcaagc ccggcgagct gtccgccttt 754381 gatatcagca gttagtgaat ccccgatgat taatgtgtgc tctgctgaaa attgaggaat 754441 ccgttcaaac acgtaattga aatattcctt catcggcttt tggaagccgg tgtcttcaga 754501 aacgaaaatg tccttgaaga atggaaataa tcctgaatca cggagacgct tatattgtgt 754561 gtgagacacg ccgtttgtca cgatgtacaa atcaaactgt tgctgcagat ttgagatgag 754621 atcaaatgca ccgtcaataa gctgatgtcc ttcttcaaga aagcggcggt atttttgctc 754681 aagcaaagcg ccgtccgctt cgtaaccgta ctccttgagc aaagcggaaa aacgtgtgtt 754741 tacgacttca tcccgtgtca tcttaccttc ttcaaaggct ctccagagac cttgattgat 754801 ggttttatac tgcgccttca tgtcatttgt taaaggaatg ttctgatctt caaacagcaa 754861 acgcagggct aaagcttctg ccgcttgaaa atcaaggatg gtatcatcta catcaaataa 754921 taaagtgcgg tatcgcttca tctgtgtgtc tccctttctc atatgtattc aaagtatagc 754981 acataaaaaa aggaaaaagc cggcgggtga ggcaccgccg gctgaaaaga gattatttgt 755041 ttaataagct gtgttttctc gaatatagga agtaaaccag cgttccgaca gcgatccaga 755101 tgacaaatga aagccatgtg acgccgggaa ggctgtacat gaaccaaagg cagatgcctg 755161 cgctgataat cggcacaacc ggaacgaatg gcactctgaa ggacgctttg atttcaggat 755221 gtttctttct taacacaatg acagcaatgg aaatgaccgt aaacgcggca agtgttccca 755281 tgttcaccag atgggccagc gttccgaggt taataaagcc ggcgattccc gctgcaacga 755341 tccctgtcag ccatgtgttg cggaacgggg ttttaaatga cggatgaacc tttgcgaaca 755401 atccaggcag aaggccgtct ctgctcatgg caaatgtcaa gcggacctgt gcgtacagca 755461 aagcgagcat caccgtcgta atcccgataa tcgcaccgac agaaataatt ccggcaacag 755521 cgtcctgtcc gacgaatttc agcgcaaagg atacaggatc tccgacattc aatttggcat 755581 aaggcatcat gcctgtcagc acaagcgata ccgcgatgta cagaaccgta cagacggcta 755641 gagctgaaat aatgccgacg ggcatgtttt tttgcggatt tttcacttcc tctgatgcgt 755701 tagaaaccgc gtcaaaccca aggtacgcga agaatacagt ggcagcgcta agtatgacgc 755761 ctttcatccc gaatggcata aaaggagacc agttatccgg tttcacatag ccgatgccga 755821 caataatgaa caataatatg atcgcgattt tcatcagtac gatgacgttg ttaaagcgtg 755881 tgctttcctt gacgcctctg ctgacaatcg cagtgatgag gagaatgatc accgcagccg 755941 gaaggttaaa tacggcgccc gccatgcttc ccggcgctcc tgtcagtgca gccggaatat 756001 gaagattgaa gccggcaagc agtgattgaa agtatgaaga ccagccggtg gcaaccgccg 756061 acagtgcaat gacatattca agcatgagat cccatccgat caaaaaggcg agcagctctc 756121 caagtgtcac gtatgagtat gagtacacgc ttcccgaaat cggaatggaa gacgaaaact 756181 cagcataaca gaaagcagcc agcgcacagg cgagccccgc taaaataaac gatatgatga 756241 gggcgggacc tgcaccggtc gctgccactg ttcctgtaat gacaaaaatc cctgtaccga 756301 tgacacaacc gataccgagc aaggttaaat caaatgcgct taacgtacgg gcaaggcttt 756361 ttgacttgct ctgcgcactc aatgtttcaa gcggtttttt tctaaataat gaactcatca 756421 aaagttcctc ctagaaatat tcaaaatatt ctaatcatta tatgcagttc ttgttgtatt 756481 atattgtcga aatttgacgt agtcaataaa atatttttct gctttaaatg atagaagcga 756541 aacagcgttg tcgtatcata ggatagtaat ttttactaat cgtatattca attttatgca 756601 agatgaaccg atagaaaaaa tagattcgcc catattttga tttgcggtta taaaggagat 756661 gctgaccatg tttcaatatg aagagttgaa taaacagttt atcggcggga aatggcagga 756721 gggcagcagc ccaaatgtat tggaaaacaa aaatccttat actcaaaaaa cattcacaac 756781 attccgtaaa gcgactgctg acgatgtaga tgaagcgtat cgggcagcgg cgctggcaaa 756841 gaaaaaatgg gatgcggtca acccgttcga gaaaagaacc attttagaaa aagccgtcac 756901 gtatattgaa gaaaatgaag aagccattat ttatttgatt atggaggagc taggcggtac 756961 aaggctcaaa gcagcttttg aaatcggtct tgtcaaaaac atcataaaag aagcggcaac 757021 gttcccaatc cgcatggagg ggaaaattct tccgtcaaca atagatggca aggaaaacag 757081 attatatcgc gtgccggcag gcgttgtcgg tgtcatcagt ccgtttaact tcccattctt 757141 tttatctatg aaatcagtgg cgcctgcact cggagccggc aatggcgttg tgctaaagcc 757201 gcatgaggaa acgccgattt gcggcggaac gctgattgcg aaaatttttg agaacgcggg 757261 aattccagcg gggctgctga atgttgttgt cacagacatt gctgaaatcg gcgacagctt 757321 cgttgagcat ccagtgccgc ggatcatctc atttaccggt tctacgaaag tcggcagcta 757381 catcggacag cttgcgatga agcattttaa aaagccgctt cttgagcttg gcgggaacag 757441 cgccttcatc gtacttgagg atgcagatat agaatatgcg gtcaatgcgg cggtgttcag 757501 ccgatttaca catcaagggc agatttgcat gtcagccaac cgcgtgcttg ttcattcttc 757561 tatttatgac aagttccttg agctgtacca ggcaaaagtg gaatcgctga aagtcggcga 757621 cccaatggac cctgatacga ttatcgggcc attaatcaac agcagacaga cggacgggct 757681 gatgaagact gtagagcaag caattgaaga aggcgctgta ccagtgaagc ttggcggatt 757741 taacgggacg atcgtggaac cgacgatctt aaaagacgtc aaaccgttca tgagcattgc 757801 caaggaagag ctgttcggac cagtcgtctc ctttatgaag tttgattcag aagacgaagc 757861 ggtggatatc gcaaacgaaa ccccgtttgg cttgagcggt gccgtacata cgtcaaatct 757921 tgagcgcggc gtggcttttg cgaaacgcat tgaaacaggc atgattcacg tcaatgacac 757981 gaccatcaat gatgaaccga atgtagcctt cggcggtgaa aagcaatcag gcctcggccg 758041 tttaaacggt gagtggagcc tcgaagaatt tacaacgctg aaatggatct cggtccagca 758101 cgaaaaacgc agcttccctt attaatgaaa aggagtgaat ggaattgacc ataaatacgg 758161 aaaaagaaac cgcagatatt ctggacgcat ttatcaaagt agccccttat ttaaacagcc 758221 tggttcagga tgatattaca atcggcattt atgatacgga aaaactgctc gtgaatatac 758281 cggccaaaac cttttcgctg aacgtaaaag ccggcgatcc gctgcaggaa ggggatatca 758341 tcacagatgc catccgcagc aatcagaaga agacgagcat ggttccgaaa gaattgttcg 758401 gcttcccatt gatcgcgcgt gccatcccgc tgcacgacga gaatggaaga gtcattggag 758461 gcgtcggcct cggaacgagc cttgaggagt cgtcaaagct gcatgatgtc gcggaaagct 758521 tatcagctgt tgttgaacaa acagccgcgg ctatttccga catttctgaa tcaattaacg 758581 ggttttcaac tcaaatgtcg ggcatttcct ctcaggcgaa aaaagtaagc gaaagcgccg 758641 gtgaaatcgc cgatatttca gtaactgtta aaggcatctc ggaccaaagc aatctgctcg 758701 gcttgaacgc cgcgatcgaa gcggcaagag caggggagtc cggaaaagga ttctctgtcg 758761 tcgcagatga gatcagaaag ctagcgacgc attcaaaaga aaatgtcggc caaattgacc 758821 agattacgaa aaaaatccac agcctgctga aagggctgga ggaatccatt gagtcgatta 758881 accagcatac agacggacaa gccgctgctg ttgaacaaat ttccgccacg atgcaggaga 758941 tttcaggaag cgcgcagcat cttgcgaaaa tggccgaaaa agcgcttgag gaagagtaag 759001 agaccgggga caaacatccc cggtcttttt cttatcctgc atttccatga aattcgtctg 759061 acgttttact agttttattc cagcggctga tttaaaatgt acacatgaac ttacgtgagg 759121 attgatagga accatgagca tattaaaagc ggaaaatctt tataaaacat acggagataa 759181 aacattattt gaccatatct cctttcatat tgaagagaat gagagaatcg gattaatcgg 759241 gccgaacgga acaggaaaat caacgctgtt gaaagtgatt gccggcttgg aatctatcga 759301 agaaggagaa atcacgaaat ccggaagcgt gcaggtcgaa tttcttcatc aagacccgga 759361 gctgcctgcg gggcaaacag tgctggagca tatctattcc ggtgaatcgg ctgtgatgaa 759421 aaccttgcgt gaatatgaaa aagcgctgta tgaactgggg aaagatcccg aaaatgaaca 759481 gcgccagaaa cacctgctgg cagcacaagc gaaaatggac gcgaacaatg catgggatgc 759541 aaacaccttg gcaaaaaccg tattgtctaa gctgggcgtc aacgacgtaa caaaaccggt 759601 caatgagctc tcaggcggcc agaaaaaacg ggtggccatt gccaaaaact taattcagcc 759661 cgctgatttg ctcattttgg acgagccgac aaaccatttg gataatgaaa cgattgagtg 759721 gcttgaaggg tatttaagcc aatatcccgg cgccgtcatg ctggtgacgc acgatagata 759781 tttcttaaac cgtgtcacca accgcattta tgagcttgaa agaggcagcc tctacactta 759841 caaaggcaac tatgaagtgt ttttagaaaa acgcgcggaa cgggaagcgc aggctgagca 759901 aaaggaaacg aagcggcaaa acctgctgcg ccgcgaactg gcttggctca gacgaggagc 759961 gaaagcccgc tccacaaaac aaaaagcgag aattgaccgg gtagagacgc ttaaagagca 760021 gacaggccct cagtcatcag gttcactcga ttttgccatt ggctcgcacc gtctcggaaa 760081 acaggttatt gaagcggaga acgtcatgat cgcttatgac ggccgcatgc tcgtcgaccg 760141 ttttaatgaa cttgtcatac caggtgaacg gatcgggatc atcgggccga acggcatcgg 760201 gaaaacaacg ctgttaaatg cccttgccgg ccgtcatacg ccggacggag gcgatattac 760261 gatcggacag acggtcagaa tcggctacta tactcaggat catagtgaaa tgaacggtga 760321 gttaaaagtc attgactata taaaagaaac ggcggaggtc gtaaaaacgg cagatggcga 760381 tatgattaca gctgaacaaa tgctcgagcg tttcctcttc ccgcgttcga tgcagcagac 760441 gtatatccgc aagctgtccg gcggggaaaa acgccgttta tacttgcttc aggttctcat 760501 gcaggagccg aatgtcctgt ttctcgatga gccgacgaac gatttggata ctgaaacatt 760561 aagcgttctt gaggattata ttgaccagtt cccaggcgtc gtcatcaccg tatcccatga 760621 ccgctatttc cttgaccgcg tcgtcgaccg tttgattgta tttgaaggaa atggtgtcat 760681 ttcccgcttt caaggctcct atagcgacta tatggaggag tcaaaagcga aaaaagcggc 760741 cccaaaaccg gcagctgagg aaaaaacggc tgaagccgag ccgaagaaaa aacggaaaaa 760801 gctttcttac aaagaccagt tggaatggga cggcatcgaa gataaaattg cccagctgga 760861 agaaaagcat gaacagcttg aagctgacat cgccgcagca ggcagtgatt ttggcaaaat 760921 ccaagagctg atggccgagc aggcgaaaac ggcggaagag cttgaggctg cgatggaccg 760981 ctggacagaa ttgtccctca tgatcgaaga actggaaagc taaaaagcgt ggccgcagca 761041 ggccgcgctt tttttcacat aatggacaaa aacgaaccgg cctgcttatg ttaggataaa 761101 gttgtgtgtc agcggcacat ggaaaactaa cggagatgat gaagtatgac atgggcgatc 761161 gtgatgttaa ttctcatgag tctggtgaaa atcgtattaa cctgtcttcc tacaggcgtc 761221 atagaatggc tgctcggcaa atttgaagtg cacgccaagc tgagtgacga aaatgcgagt 761281 ctctctctag atggaaaacg cctcgagggt gcagagaagc agaaagtgat tgatcaattt 761341 aacgaagcta tcttcctgga aaaatattat atctatccag gtgatgaaga gcgttattta 761401 catccggaaa acggcggcac gcctctggtg atagatacaa aaaaaggaaa aaaagacgtg 761461 aagctgttcg tgtaccgcta cgacgaccat atcgacgtcg tgaaacagta caagaagaaa 761521 gtgatcgcgt atcgagtgct ttctgaaagc cttcaaaaag agtctctgtc agtggcggga 761581 agtttagctt aaacaggaaa gtgaaagacg ggtgctgtat gctgctcgtc ttttttattg 761641 ttttttaaaa cttaacgttt acgttaaggt tcaaaaggtg tataatggta acagaaacgg 761701 cgaaggggga tttaccttgg aatggatgaa gattgatcaa gtggccaaaa gaagcgggct 761761 gacaaagcgg accatccggt tttatgaaga aatcggcttg attccggcgc cgaaacggac 761821 agacggcggt gtaaggcttt attcagagga tgatatggag gagcttgaga aagtcatcag 761881 cacaaaagag gtgctcggtt tttcccttca ggagcttcag catttcatgg aaaccagccg 761941 ccagctagag ttaaacaaag aggggtattt gttgtcactg gatcctaagg aacggaaaga 762001 aaaactggag gaaattcagg aaaccctgaa tcaccagctg gatttgattg atgagaaaat 762061 ccgcacattc caaagcttta aagaacgcct gcagggcatg aaaggcaaag cggaacgcgc 762121 cattcaatca atcgaatgaa aagtttgtta aacgctattt ttgtagcgtt tcttttaatg 762181 gaataaagat ggaggttagg tcaaatggat aagacaacac aagtgaatca gaaaacgggt 762241 ttgctcagcc agccaaaagc ggtatgggct gtcgcgtttg cctgtgtgat ttcttttatg 762301 ggaatcgggc tggtcgatcc aattcttccg gccattgccg cacaattgca tgcttcacct 762361 agtgaagtat cactcttgtt tacaagttat ttgcttgtaa ccggatttat gatgtttttc 762421 tcaggagcca tttccagccg catcggcgcg aaatggacat taattctcgg acttattttt 762481 attattgtgt ttgcggggct tggcggcagc tcaagctcaa tcgctcagtt agtcggctat 762541 cgcggcggct ggggattagg gaatgctttg tttatttcaa cagcgcttgc ggtcatcgtt 762601 ggcgtgtcag tcggcggcag cgcccaagcg attattttgt atgaggccgc gctcggtctc 762661 gggatttctg tcgggccgct tgcaggcgga gagctcggaa gcatttcatg gcgcgcaccg 762721 ttttttggag tatctgtcct gatgtttatt gcgttaatcg cgatttcttt catgcttccg 762781 aagctgccga aaccggcgaa acgcgtcggt gtgtttgatg cgatgaaggc actcaaatat 762841 aaaggcctgc tgacaatggc ggtatcggca ttcctataca actttggatt ttttattttg 762901 ctagcttatt ctccgttcgt actggattta gatgaacacg gtcttggata tgtcttcttc 762961 ggctggggcc ttctgctggc gattacgtca gtctttacgg cgccgctcgt gcacaaagcg 763021 ctgggcacag tgcgttcgct agtcgttctc tttatcgcct ttgcggccat tctcgttatt 763081 atggggatct ggacagacca tcagactttg attattacat gtatcgttgt cgctggtgct 763141 gtcctcggta tggtgaatac gatcatgaca accgctgtga tgggttctgc gccggttgaa 763201 cgttcaatcg cgtcttcagc ctacagctca gtccgcttca tcggcggcgc gctcgccccg 763261 tggattgcag gaatgctgtc agaacacttt actgcaagca caccatatac agtaggcgga 763321 atcgtcgttt ttgtcggcat gcttgtcctt ctcatgggac gtaaacatct tgctggaatt 763381 aaggcggggc attaataacg aaagacactg cgcatatgca gtgtcttttt attcgttata 763441 atgcatcata atcgaattgg tgcaggaaag gacaaccttt atgacacaat tttactattt 763501 tccggctgaa aactcccttt agaaaccggt tttttcggtc agcaagaacg gcgttcgcgg 763561 aaagggcatc cgcttcggtc aggcattgat gcggctggga tttatcttgc agaagctgag 763621 aatgtgtccg ttcatttacg attgccattt cagtgatggt tcatgctgta gaggggacgt 763681 ttgccatgga taaggcaaaa cctgacgaat atgatcagaa atgtttagaa acgctctatc 763741 aatacataca cagcgtcatg aaaaacagct tttctcggtc gagtggttta ccgcttggga 763801 agatgaggag gattttgagc tgtctgccaa aagagagctg acacttgatg aattcacatc 763861 tccattgcag ctcattttaa aagacagaga gcttttgaga atcgttcaga aaaaatggca 763921 gtaaaaaacc cgccctttag caggcgggtt tttttataaa ttaaagcact ttcgtcgtcc 763981 aagactcgca gttccacgtt tctgtcgcaa tatccatata aaagtctggc tcgtgggaaa 764041 tgagcagaat ggagccttta tattctttca gggcgcgctt gagctcttcc ttggcatcgg 764101 catccaagtg gtttgtcggc tcatcgagca ccagcaggtt tgtttctgag ttgattagct 764161 tgcacaatct gactttcgct ttttcgcctc cgcttaatac ggagacgcgg ctttcgatat 764221 gctttgtcgt cagcccgcat tttgccagag cggcacggat ttcatactgc gtataagaag 764281 ggaattcgct ccatacttct tcgatgcacg tattgttgtt tgtttccttg acctcttgct 764341 cgaaatagcc ggtatagatg tgctcaccgc gttcaacaga gccttcgagc ggctggattt 764401 caccaagcaa acttttcagc aatgtcgttt ttccgatccc attcgcgccg taaagggcga 764461 ttttttggcc gcgctccatg cggaggttga gcggacggga cagcggggaa tcgtaaccga 764521 tcacgagatc cttcgtttca aaaatcagct tgcctgacgt tctcgccggc ttaaagtgga 764581 attccggctt tggcttttct gccgcaagct cgatcatatc catcttatcg agtttctttt 764641 ggcgggacat cgccatgttt ctcgtgctga cacgcgcttt gttgcgggcg acgaaatcct 764701 tcagctccgc gacttcctgc tgctgctttt tgtaggccgc ttcaagctgc tgttttttca 764761 cctcgtagac ttccataaac tgatggtagt cgccgacata acgtgtcagc tcttgatttt 764821 caacgtgata aatcaggttg atgacactat tcaagaacgg aatatcgtgg gaaatcagga 764881 tgaacgcgtt ctcgtattcc tgcaggtagc gtttcagcca ttcaatatgc tgttcatcaa 764941 gatagttggt cggctcatcg agaagcagaa tttccggctt ttcaaggaga agcttagcga 765001 gaaggacctt tgtgcgctgt ccgccgctca aatcggtgac atctcgctct aaaccgatat 765061 cgctcaaacc gagaccgcgg gcgatttctt ccaccttgga atcaatgaca taaaaatcat 765121 tgtttgtcag cgcgtcttga atgacgccga cttcttcaag cagcttctcg agctcgtcgg 765181 gatcagcctc gcccattttg ttgtaaatct cgttcatttc ctcttccatc gcaaataaat 765241 aatggaatgc gtctttcagg acgtcgcgaa tggattttcc tttttccagc acggtatgct 765301 gatcaaggta tccgacacgg acattttttg accattcgac ttttccctca tcaggttcaa 765361 gctttccggt aataatattc atgaaggttg attttccttc accgtttgcg ccgatcaagc 765421 cgacgtgctc gccttttaac aggcggaagg aaacgttatt aaaaatggcc cggtccccga 765481 aaccgtggct taaatccttt acagataaaa tactcatgtt tacacctcta tcgttatcaa 765541 acacgcacaa tcggcgtgta atattcaccc ttttgattat aaaggaggat tcggaatgtt 765601 gaaaggtata ggaaagaaaa agaaaaattg cgttccgggc gaggttttga gatactatgg 765661 aatagatttc aggaattgag gagaacaaaa tgacgcaaac ttggccattt ttacataatg 765721 cacaatcatt tatacaagag aattggaatg cttccggctt tcaaaagcca acccctgttc 765781 aggagcaggc agcccagctg atcatggacg gaaaggatgt cattgcagaa tcgccgacag 765841 gcacagggaa gacgctggcg tatgcgctgc cggtcttgga gcggatcaaa ccagagcaaa 765901 agcatccgca ggcggtgatt ttagcgcctt cccgtgagct ggtcatgcag atttttcagg 765961 tgattcagga ttggaaagcg ggctcagagc tgcgcgcggc ttccttaatc ggcggggcga 766021 atgtgaagaa acaggtcgaa aagctgaaga aacatccgca tatcatcgtc ggcacgccag 766081 gcagggtgtt tgaactgatt aaagcgaaga aactcaaaat gcatgaagtg aaaacgatcg 766141 tgcttgatga aacggatcag ctcgtcctgc cggagcatcg cgaaacgatg aagcaaatca 766201 ttaaaacaac attaagagac cgccagcttc tatgtttttc tgccacgctc aaaaaggaaa 766261 cagaggacgt gctccgcgaa ttggcgcaag agcctgaggt gttgaaggtg cagcgaagca 766321 aggcggaggc agggaaagtg aagcatcaat acctgatttg cgaccagcgc gacaaagtga 766381 agctgctgca aaagctgtca aggcttgaag gcatgcaggc actcgtattt gtgagagaca 766441 ttggcaacct gagtgtatat gcggaaaaac tggcatatca ccacgttgaa ctcggcgttt 766501 tgcacagtga agcgaaaaaa atggagcgag cgaaaatcat tgccacattc gaagacggag 766561 agtttcctct tttattggcg actgacattg ccgcacgcgg tttagatatt gaaaacctgc 766621 catacgtgat tcatgctgat attccagatg aagatggcta tgtccacaga tcaggacgaa 766681 caggccgggc cggaaaagaa ggcaacgtgc tgagccttgt gacaaaattg gaggaatcta 766741 agctgaaaaa aatggcgaag aagcttggtg ttgagctgag tgaagctgtg tatgcaggcg 766801 gaaaactgaa gacgaaataa aaagaagggc gaagagccct ttttttgttg taaaataata 766861 gaaaagattt tgcgcggagg tgggaaaatg gcttcaatag acaggtttca agtaatgcag 766921 gagccagagc tgaaaatcct tgaacactgg tttgagaatg aggataccag acggagaatg 766981 gatgggatgc tgctattaga tgagtggtat gcacgagtaa ataaagataa acacgatact 767041 gtcatcatgg cgtatgatgg acagctgccg gcagggatgg tcgttattga gttcggagag 767101 gagcggacat atattggatt gatcgtcaat cctttgtacc ggcttaaagg gtatggaaaa 767161 cagatactgc aaaagctgat gaccgaacct gattttacta gcgtgcgaga atgggtggca 767221 tgcattgaag aagacaatcg aatcagttta gcttgctttc aagcagcagg attcacttta 767281 gaagacacgg aacctgatga agatggtttt cttacgctga ttcttcgcaa ctgatctcat 767341 cgaaacacaa aaggagggca aaaagccctc ccgttttcat cttcattcag ctcggatcac 767401 tgaccttgat cagctgtttc cctttatttt ctcccttaaa taaaccgaga aacgcgtcag 767461 gaatgttttc gaagccttct gtgatggttt cctcgtaatg gagtttacca gccttcagcc 767521 attctgccag ctgttttgct ccctcagaaa aacgatcgga gtagtcgctt acgataaagc 767581 cttgcatcag cgacttcgtt ttaatgagtt ttgattggac acgagggccc atgtcatctg 767641 cttcgctttc tgcgttatag gaagaaatgg cgccgcacac cggaatgcgg gcaaattcat 767701 tgagcagatt catcaccgcg tctgaaatcg gtccgccgac attgtcaaaa tacacatcga 767761 caccgtcagg acaagcgttt tgaagcgctt tttggatatc atccgctgtt ttgtaattga 767821 tggcttcgtc aaactgaagc tcctgtttta aatagtcgat tttttcatca gagcccgcga 767881 tgccgacgac tcgcgcgcct ttgattttgg caatttgccc gactgttgaa ccgacggctc 767941 cggcagctcc tgagacaacc acggtttcgc cttccttcgg gcgtccgatg tccagcaatc 768001 cgaagtatgc tgttaagccg gtcattccca aaatgccgag ataggccgaa gcgggagcaa 768061 ggcttgtatc aatttttcgc aaggcagact cgctcacagc ggaaaattcc tgccagctga 768121 gatttccgat gacgatatcg ccttttttca gatgattccc gtctgacaca acttcagcga 768181 taacccctcc agaaagcgct ttatccaagg cgaacggctc aacatatgac ttcgtatcct 768241 gcatacggcc gcgcatataa gggtcaaccg atacataaag cgttttgaca agcacttccc 768301 cttgcttggg ttcaggaacc ggaatggttt caaagcgaaa gtcttcatga acaggaatac 768361 cttgtggacg tcttgctaat tgaatttgct gctgagatgc tgtcattttc atcctcctat 768421 cacttggttg acaccactgt aacatggaca ggagaggaaa tacaaaaggt aagctggcat 768481 acaaaaaagg ttatagatga gcttatgctt tctacaagct cttttgtttt aaaagttctc 768541 tttagtcatt tatcattatt agaaaacaga acagaaaaag agctcctgta cacctagcta 768601 agattggcta gtgtgtatgt cgattctttt tcatattctt gcaagcatct gcgaggggga 768661 gcttagtcgt tcacattttg ctttcgcatc aatctgcaat agcaaagtct atgcgatttt 768721 tttacatcag caaagatttg ttcaattttt tccttttatg ccgagttttt ctgaaacaga 768781 taattgatgg tactcaacca ttttcttttg gtcaataaag taatgtttac ttattaatta 768841 aacacgcgaa aaagcaaacg aaaacataat taaattttat atatttatta aaagcttata 768901 tgtttattta cctttttttt gaattgtaat tgagaaaatc catatattgc ggacactaat 768961 aaaagaatac ctgctgaaac ataaactaaa cgaactccaa ggaaatctga aatagcccct 769021 atagccagaa ttgaaaacat aaaaatgaac tgtactaaag aagaccttgc agacattata 769081 ttaattcgag tttgctcggt tgttatgttc tgaataagtg tttcttgtgt aagatctctt 769141 aatatataag ccggccccat aaagagaacc aaaattagag ctaagtatga attacttata 769201 aaaccatata ttaaagttaa acttccatat gagacagcgc caattaacat aaaattaatt 769261 aacttatttt gaaatctctc cgacagctta tatattataa atccccctat catcgaacct 769321 aaataatatg ctccattaat aaatccccac catgattctc ctttatgcaa gacttcgtta 769381 acgaaagcta aagagacaga tcctatccaa atcattcctg cccatgactc aattaaatcc 769441 ataataataa ttgttctaag tttcttttgg ctaaataaat accgccaacc acttactata 769501 ctcttattgg gagaattttt ttcacgtatg acagaattag cgtggccatg tggtagacaa 769561 aataaaagag aaagaagaga tgtaaacaac aaaaagatag taagtataat ggtatatccc 769621 tcacctaaaa atgcaattat gagaccacct aaagaccagc ctacaaattg aaaagtttgg 769681 tccactgtag ataataatcc atttgctttt actcttctat caggagagat tatttcccct 769741 ataattgcac tttttaaagg tgagaaccat ccattaaaaa aggaaataca gctaataata 769801 ataaagacta aaatgagagt ttgattagag taagttctta ataaagcata gaacaaacat 769861 attaataaca gcatttgtat caattgagaa ataattattg taagaggcag ttttaatcga 769921 attgttatta acggtaatat agcacttcca aaaatacgaa aaataatact tattaatgtc 769981 accatagagg cgatggttgt cgaattggtc attttaaaca aaaacgaaat cactaccata 770041 gtatatagag aaaaacctaa atttgtagtg gtctggctaa ataaaataga ataataacct 770101 ttactcatat gtatcctccc ttggaataat ttttctcggt aaagagctta aacatattta 770161 aacaccttaa aacaacaaaa gtaaagaaaa aatttccttg taaactattt acttttattc 770221 tatttattgt tattgtttat ttaagttctc tgactattct atcaatattc agggaaccac 770281 atatcttatt aaagggggga aaaccatgag aaaattaaga aaaaactgga gaaaatcgat 770341 tgttagcccg gttctttata ctaatgaaaa atggtaaaca cttagggaat agcatttaat 770401 gctattcctt atttcaacaa acaaatcggg aggttatcgt aatttgactc tattaatgca 770461 agatcataaa tcaatttaca ataaagatat agaaatatta attgaagttg aagaacttat 770521 tacttctgtt ccagaaaata aaaaaaatga ttttaagagt ttaatcgata atagaattat 770581 gactctacta aataaaattc aacaccctgt agcagcggaa aatgtgtttg ggatgtgtat 770641 tgcttatccg aatacttaca taaggtatag attaattgat ttcgttgaaa aatgggtacc 770701 ttatttctct gctgtagaaa ctataatcaa tctaacccag gatccggatg atttagtttc 770761 ttttaaagct atggatgtct gtgcaaatca taaaattgaa gaatctgtag catatttgtc 770821 ttcgattatt gatgatgtcc gggagagtat aagctaccct aaaaaacctg tgggattagg 770881 ggcccaaaaa gtattaagta cattattaga tatattcggt gttgaaaaac atgaagagct 770941 agtaatgcta aaaaattatt ttgatcaaaa tggtatactt cctaataact ttgactttga 771001 agaaaaaatt cctcaaagtc taatagagga attcgaaaaa acagaagaag atgggatgat 771061 tttaattccg ggtggctttt ttgaattcgg tttaaatgaa aatgaaattc ctgacaaaac 771121 atttaattgg aaagatgctg ttcctagaca aaaagtatgg ttacctccat tttttatcga 771181 taagtatcct gttacaaata aagattatga tatctttacc gagttcatag aggaaaatgg 771241 gcatatattc tgtcatccta atgaaccgca gaataaacaa catagaagaa atacatattg 771301 ggatgatagg tatttagata atcatcccgt tacaggtata gatttttatg atgcatttgc 771361 ttacgcaaga tataagggga aagaattgcc aaccgagttt caatgggaaa aagctgctcg 771421 aggcgaaaag ggtaatgtct ggccttgggg agataaattt gatcctgcaa aggttcaata 771481 tgctggaagt ctttataatg aacccattac ttctttaaag tcctggagag aaaatttatt 771541 aaaagctcat gctgataaag aattaaatca tttaacaagt gatatttttg aacaaaatgg 771601 tgaaagtccc tatggagtat gcggtatgat cggcggaaca tgggagtgga ctagaagtga 771661 gcttaaaaca aagagagctt tccaccctat ttttgagaat gtaccattta atagtgttaa 771721 ctcatttgcc gttcttaaag gaggatcatt cttctctcat ccaggcttaa tgttcccttc 771781 ttttagagca aaagatattc ctttctgtcg acacaatgaa atggggatta gatgcgtaaa 771841 gaatattcca gtatataaaa ttagagaatc aattaatggg ccaattacta ataaagcaat 771901 ttattaatca ttctaggtta gagacttgat aaaagtatac taacattgtg tagtaatgtt 771961 cagcttgtag aaaaaacaat gttttttcta caagatttta ttttaaatgc ttttcaaaat 772021 tatcagggat tgagaatcag aaaaagagcc attaagctcg atcttagcta ggtattacga 772081 tcttctgtat attattgtga gaaatataga agattcagtt agttagcatt tcgattttaa 772141 gctgagcctg caatagcaaa gcatctgttt tgattattct ttttctgata cataagctaa 772201 ttttgtcgct tttctttttt gtcttttcac gcatttcgag gatgacttac tataattctt 772261 tcagcttttc tatgtgttaa gattcgaata gatgaaataa ctttaacaag ttggtcaata 772321 agaacagatt taactttatg ttaaaagagt atctcgtata gaacataaga agaatgacga 772381 gttttttaag attatcatca attatgtgag aataaaatat tataagggaa aatgaaggct 772441 gtcacgtttc tcgacagccc tagggaattc ctctcctttt catttcgccc gtaatttcgg 772501 gcacagtccc gtcggcaggc acattggctt ctggtcgatc gggcttctca tgatgcagca 772561 ttccaagccg aagacttcac ggaaaaatgg ctgggtgaac acatcttccg gtgttccggc 772621 gttgtatatt tttccgtcca gcacactgat cagatagtca gcatattgag cggcttggtt 772681 taaatcatgg agcaccatga caacggtgcg gccatggtcg cggttcagct ttttcagcag 772741 ttcaagcact tcaatctgat gtgagatgtc taaatacgtg gtcggctcat caagcaaaag 772801 caaatcagtg ccttgcgcaa gtgccatgga aatccaggct ctttgtcttt ggccgcctga 772861 gagggcatca agtgtccgat ccttcagttc aatcatgccc gttgcttcca gcgcccactc 772921 taccatgtca tgatcctctt gggtatgctt ggataacagc tttttgtgag gatgtctgcc 772981 aaaatagcat aattcctcta ccgtcaatcc ttcaggagcc tgaggagatt gtggaagaat 773041 ggccagtttt tttgcgactt cttttgatgg ctggcggtgg atgtcttttc cttctagtag 773101 cactgtaccg ctttttgggg ccatcagcct ggcgagcgat ttgaggattg ttgatttacc 773161 gcagccatta gcgccgatga gcgcagtgat ttttccttct tctatcttta agtcgactcc 773221 gtcaataatc actgtactgt catatgaaag agtgagctgg tctgcagcca gttttcccat 773281 ggtatcctct ccctactgtt tcctcgcttc gaatttcaat aaatataaga aataaggcgc 773341 gccgatcacg gctgtcagta ttccggcagg tatttcaacc ggaggcatga tgccgcgccc 773401 taacgtatct gcaattaata atataatagc accaatcaat gccgatgcag gcagtaaata 773461 tttagctttt tctccggtaa gccgtctggc gatatgcgga gcaagcaagc cgataaaacc 773521 gattgagccg acgacggcta cacagcttcc cgccagcgcc accgcggtga aaatcaggat 773581 gaatctcagc cggtttgcgt tttctccgag accctgtgca agctcatccc cgagtgacat 773641 aagatccagc ttcggtatga gtatgcagac gatcggaaaa agaatcaaaa gccatggcgc 773701 aagcagcttg acttcttccc agtttcttcc ccagaggctt cctgtcagcc aaatgagtgc 773761 agcattcacg tcgcctggaa acttgaccat catatattgc attccggcgt ggcagaccgc 773821 gcctaaagca atgcctgata aagccagtga agagggctga atgctctttt ttcgggctat 773881 cattaataat agtacagcaa taatggcggc tccggcaaat gcggagaacg gaagcacgta 773941 taccggcgac tcaggaaaga tgagaatcac agccatcgcc gcaagtccgg agccttttga 774001 aatgccgaca acgtccgggg aagcgagcgg atttcggatc acaccctgta aaatcgctcc 774061 ggcagcggca agtccagcac ctgccaaaat cgctaatata atgcggggaa ggcgatattg 774121 ctggatgata aattcaaagg aatgatccag tcccagcaga ttcgtcacta ccgcatcagg 774181 tgaaatgtat aatgcaccga ttccaatgct gatgacggac agaacgatta aaatcacggc 774241 caatatgagt atcgccagta aggggcgttt ttgttttctg gttgttttct tcatttcagg 774301 tttcgccctt tccttgccaa atataagaaa aacggcgttc cgataatcgc ggtgacaatg 774361 ccgaccggtg attcataagg aaatgcaatc catctggcca gaacatctgc gtacaccagc 774421 aaaatggcac cgaacagtgc cgaaaacgga agcacgtatt gataatgttc tccgatcagc 774481 ttgcggacaa tatgcgggac gagcagcccg acaaagccaa tcggcccggc gacggctacg 774541 gaagcgccgg aaagaattaa aataatcaaa ctgatcagaa tcctgatgcc gttcatattt 774601 tgtccaagcc cttttgctgt ttcgtctccg agaccgagaa cagaaacaga accggaaaat 774661 acgagggcaa gcccgatgcc aatgacagaa aaaggagcga tggttatgac gtcctgccag 774721 ttgctgccgt cgattgcgcc tgtcatccag tacagaacat cctcacctga ctcatttaaa 774781 ataatgatgg cctgtgtcat agaggagagg aacaagtgca cggccattcc tgacagcgcc 774841 agcttgacag gcgtcattcc gccggatgag gcaatcatat acacaatcgc gccgcctgct 774901 gccgcacccg caaaagcgaa tataacagat gaatagggcg atgccggcag aatgacgaga 774961 gaagcaacaa caaaaagcga tgcacccgca ttcacaccga aaatttgggg tgaagccaga 775021 ggatttctgg tcatagcctg catcagcgcc cctgctacag ctaggctggc gccgacaaaa 775081 acgccgatta atgtgcgggg aaggcgaaga gtagagatga tgagctgttc ctttgaaccg 775141 tcccatacaa aaagatattt caatgaatct atgatgctga tgtctgaggc tcctactgaa 775201 agattcagcc caagcccaaa tataaaaata atcagtgcaa tgataaacat catcagtctt 775261 gatgatgagc gccgtttggc tgaatgatac aacagtctca cttccttact gcgtctggtt 775321 gcaaaaacga agaagcaagg attcccctcg cttctcattt gtcctattta ttatacactt 775381 ttttaagcac atctttggcg cttgtttcac tagacttgat gcctctgaat cttgtccaag 775441 tgtcacggtc cgcatcatag acttgtccat ttttcaccgc tttgagattt ttccagagcg 775501 ggttcgtttt ccactcatct acaatggttt tgccttcgtt ggctgagatg aacaaaatat 775561 caggatcgat tttgctcaat tgctcaaggc tgacctcttg ataggcgtta tctgacttca 775621 cagcgtgtgt aaagcctagc attttaaaga tttctccgtc ataggatgat gatgtatgaa 775681 gctggaagga atccgctctt gcaacgccga gaacgatgtt gcggttttca tctttcggaa 775741 gttcggcttt tagatcgttg atgacttttt tgtgctcggc aagcttttct tttccttcat 775801 cttctttatt taatgcttta gcaatggtcg taaagctgtc gatcgtttcg tcatatgtcg 775861 cttcacggct ttttaattca atcgtcgggg cgattttttt cagctgttta taaatgtttt 775921 tatggcgctc agcgtcagcg atgattaaat caggcttcaa ggaactgatg acctcaagat 775981 tgggttcgct gcgtgtgcct acagatgtgt aatcaatgga gctgccgaca agctttttaa 776041 tcatatcttt tttgttgtca tctgcgatgc ccaccggcgt aatgccgaga ttgtgaacgg 776101 catccaagaa tgaaagctca agcacaacca cccgcttagg tgtgccgctt actgtcgttt 776161 ttccttcttc gtcatggatc actctggaat ccttagactc gcttttgccg cttccgttgt 776221 tattctggct tgatgaacag ccggatacaa tgaggcaggc gagcaataaa acactcatga 776281 tggcaatcaa cttgttagaa taggtgcgca tgtcattctt ccttttttca gatttagtaa 776341 tgagaatcat tatcacatgt aacactataa tagcatggct tatcatgtca atattttttt 776401 agtaaagaaa gctgcgtttt tactgctttc tcatgaaagc atcatcagac acaaataagt 776461 ggtatgcagc gttaccgtgt cttcgagaca aaaacgcatg ggcgttggct ttagaggttt 776521 cgaacatatc agcagtgaca taaggaagga gagtgctgag ataaccggac aatttctttt 776581 ctatttcatc tgttagtgca aattcaatgt cgccgatatt catgataatc gagaaaacaa 776641 agtcgatatc gatatgaaaa tgttcctcgg caaaaaccgc aagctcgtga attcctggtg 776701 aacatccggc acgcttatgg aaaatctgtt tgactaaatc actcacaatc caagcattgt 776761 attgctgttc tggtgaaaag tattgcatta gacatacctc ctgctcgtac ggataaaggc 776821 agcgtttcat ggtcgtgtgc tccgtgcagc ggcttctcct taattttgat ttttctgaaa 776881 ataggtcccg ttcctatcac tttaccatgg acggaaaaca aatagctact accattcctc 776941 ctgtttttct cttcaatgtt ctggaatctg tttcaggtac agacgatcgg gtatgaaaga 777001 aatatagaaa acatgaagga ggaatatcga catgaaacca gttgtaaaag agtatacaaa 777061 tgacgaacag ctcatgaaag atgtagagga attgcagaaa atgggtgttg cgaaagagga 777121 tgtatacgtc ttagctcacg acgatgacag aacggaacgc ctggctgaca acacgaacgc 777181 caacacgatc ggagccaaag aaacaggttt caagcacgcg gtgggaaata tcttcaataa 777241 aaaaggagac gagctccgca ataaaattca cgaaatcggt ttttctgaag atgaagccgc 777301 tcaatttgaa aaacgcttag atgaaggaaa agtgcttctc tttgtgacag ataacgaaaa 777361 agtgaaagct tgggcataaa gcaaggaaaa aaccaaaagg ccaatgtcgg ccttttggtt 777421 tttttgcggt ctttgcggtg ggattttgca gaatgccgca ataggatagc ggaacatttt 777481 cggttctgaa tgtccctcaa tttgctatta tatttttgtg ataaattgga ataaaatctc 777541 acaaaataga aaatgggggt acatagtgga tgaaaaaagt gatgttagct acggctttgt 777601 ttttaggatt gactccagct ggcgcgaacg cagctgattt aggccaccag acgttgggat 777661 ccaatgatgg ctggggcgcg tactcgaccg gcacgacagg cggatcaaaa gcatcctcct 777721 caaatgtgta taccgtcagc aacagaaacc agcttgtctc ggcattaggg aaggaaacga 777781 acacaacgcc aaaaatcatt tatatcaagg gaacgattga catgaacgtg gatgacaatc 777841 tgaagccgct tggcctaaat gactataaag atccggagta tgatttggac aaatatttga 777901 aagcctatga tcctagcaca tggggcaaaa aagagccgtc gggaacacaa gaagaagcga 777961 gagcacgctc tcagaaaaac caaaaagcac gggtcatggt ggatatccct gcaaacacga 778021 cgatcgtcgg ttcagggact aacgctaaag tcgtgggagg aaacttccaa atcaagagtg 778081 ataacgtcat tattcgcaac attgaattcc aggatgccta tgactatttt ccgcaatggg 778141 atccgactga cggaagctca gggaactgga actcacaata cgacaacatc acgataaacg 778201 gcggcacaca catctggatt gatcactgta catttaatga cggttcgcgt ccggacagca 778261 catcaccgaa atattatgga agaaaatatc agcaccatga cggccaaacg gatgcttcca 778321 acggtgctaa ctatatcacg atgtcctaca actattatca cgatcatgat aaaagctcca 778381 ttttcggatc aagtgacagc aaaacctccg atgacggcaa attaaaaatt acgctgcatc 778441 ataaccgcta taaaaatatt gtccagcgcg cgccgagagt ccgcttcggg caagtgcacg 778501 tatacaacaa ctattatgaa ggaagcacaa gctcttcaag ttatcctttt agctatgcat 778561 ggggaatcgg aaagtcatct aaaatctatg cccaaaacaa tgtcattgac gtaccgggac 778621 tgtcagctgc taaaacgatc agcgtattca gcgggggaac ggctttatat gactccggca 778681 cgttgctgaa cggcacacag atcaacgcat cggctgcaaa cgggctgagc tcttctgtcg 778741 gctggacgcc gtctctgcat ggatcgattg atgcttctgc taatgtgaaa tcaaatgtta 778801 taaatcaagc gggtgcgggt aaattaaatt aagaaagtga aaaacacaaa gggtgctaac 778861 ctttgtgttt tttaattaat taaaatgttt attaacttag ttaaggagta gaatggaaaa 778921 ggggatcgga aaacaagtat ataggaggag acctatttat ggcttcagaa aaagacgcag 778981 gaaaacagtc agcagtaaag cttgttccat tgcttattac tgtcgctgtg ggactaatca 779041 tctggtttat tcccgctccg tccggacttg aacctaaagc ttggcatttg tttgcgattt 779101 ttgtcgcaac aattatcggc tttatctcca agcccttgcc aatgggtgca attgcaattt 779161 ttgcattggc ggttactgca ctaactggaa cactatcaat tgaggataca ttaagcggat 779221 tcgggaataa gaccatttgg cttatcgtta tcgcattctt tatttcccgg ggatttatca 779281 aaaccggtct cggtgcgaga atttcgtatg tattcgttca gaaattcgga aaaaaaaccc 779341 ttggactttc ttattcactg ctattcagtg atttaatact ttcacctgct attccaagta 779401 atacggcgcg tgcaggaggc attatatttc ctattatcag atcattatcc gaaacattcg 779461 gatcaagccc ggcaaatgga acagagagaa aaatcggtgc attcttatta aaaaccggtt 779521 ttcaggggaa tctgatcaca tctgctatgt tcctgacagc gatggcggcg aacccgctga 779581 ttgccaagct ggcccatgat gtcgcagggg tggacttaac atggacaagc tgggcaattg 779641 ccgcgattgt accgggactt gtaagcttaa tcatcacgcc gcttgtgatt tacaaactgt 779701 atccgccgga aatcaaagaa acaccggatg cggcgaaaat cgcaacagaa aaactgaaag 779761 aaatgggacc gttcaaaaaa tcggagcttt ccatggttat cgtgtttctt ttggtgcttg 779821 tgctgtggat ttttggcggc agcttcaaca tcgacgctac cacaaccgca ttgatcggtt 779881 tggccgttct cttattatca caagttctga cttgggatga tatcaagaaa gaacagggcg 779941 cttgggatac gctcacttgg tttgcggcgc ttgtcatgct cgccaacttc ttgaatgaat 780001 taggcatggt gtcttggttc agtaatgcca tgaaatcatc cgtatcaggg ttctcttgga 780061 ttgtggcatt catcatttta attgttgtgt attattactc tcactatttc tttgcaagtg 780121 cgacagccca catcagtgcg atgtattcag catttttggc tgtcgtcgtg gcagcgggcg 780181 caccgccgct tttagcagcg ctgagcctcg cgttcatcag caacctgttc gggtcaacga 780241 ctcactacgg ttctggagcg gctccggtct tcttcggagc aggctacatc ccgcaaggca 780301 aatggtggtc catcggattt atcctgtcga ttgttcatat catcgtatgg cttgtgatcg 780361 gcggattatg gtggaaagta ctaggaatat ggtagaaaga aaaaggcaga cgcggtctgc 780421 ctttttttat tttcactcct tcgtaagaaa atggattttg aaaaatgaga aaattccctg 780481 tgaaaaatgg tatgatctag gtagaaagga cggctggtgc tgtggtgaaa aagcggttcc 780541 atttttccct gcaaacaaaa ataatggggc tgattgcggc tctgctggtc tttgtcattg 780601 gtgtgctgac cattacgtta gccgttcagc atacacaggg agaacggaga caggcagagc 780661 agctggcggt tcaaacggcg agaaccattt cctatatgcc gccggttaaa gagctcattg 780721 agagaaaaga cggacatgcg gctcagacgc aagaggtcat tgaacaaatg aaagaacaga 780781 ctggtgcgtt tgccatttat gttttgaacg aaaaaggaga cattcgcagc gcctctggaa 780841 aaagcggatt aaagaaactg gagcgcagca gagaaatttt gtttggcggt tcgcatgttt 780901 ctgaaacaaa agcggatgga cgaagagtga tcagagggag cgcgccgatt ataaaagaac 780961 agaagggata cagccaagtg atcggcagcg tgtctgttga ttttctgcaa acggagacag 781021 agcaaagcat caaaaagcat ttgagaaatt tgagtgtgat tgctgtgctt gtactgctgc 781081 tcggatttat tggcgccgcc gtgctggcga aaagcatcag aaaggatacg ctcgggcttg 781141 aaccgcatga gatcgcggct ctatatcgtg agaggaacgc aatgcttttc gcgattcgag 781201 aagggattat tgccaccaat cgtgaaggcg tcgtcaccat gatgaacgta tcggcggccg 781261 agatgctgaa gctgcccgag cctgtgatcc atcttcctat agatgacgtc atgccgggag 781321 cagggctgat gtctgtgctt gaaaaaggag aaatgctgcc gaaccaggaa gtaagcgtca 781381 acgatcaagt gtttattatc aatacgaaag tgatgaatca aggcgggcag gcgtatggga 781441 ttgtcgtcag cttcagggag aaaacagagc tgaagaagct gatcgacaca ttgacagagg 781501 ttcgcaaata ttcagaggat ctcagggcgc agactcatga attttcaaat aagctttatg 781561 cgattttagg gctgcttgag cttggggagt atgatgaagc cattgatctg attaaagagg 781621 aatatgcgat acaaaatgaa cagcatgatc ttttattcca taacatccat tcgcagcagg 781681 tgcaggccat tttgttaggg aaaataagca aggcatcgga aaagaaggtc aagctggtga 781741 ttgatgagaa cagctcactc gcgcctcttc ctgcgcatat cggcttgtcc catcttatta 781801 cgattattgg caatttaatt gataacgctt tcgaagctgt agcggagcaa agcgtgaagg 781861 aagttttgtt ttttatcacg gatatgggcc atgacattgt cattgaagta tcagacacag 781921 ggcccggtgt gccgccagag aaaatagaag ctgtgtttga gagaggctat tcttcaaagg 781981 ggatgaggag aggctacggt ctggccaatg tgaaagactc agtgcgtgaa ctgggcggct 782041 ggatcgaact ggcgaatcaa aaaactggcg gggcggtatt cactgtattt ataccgaagg 782101 agaaacaaag ggggaatcca tttgattcac atcgcgattg cggaggatga ttttcgagtt 782161 gcgcaaatcc atgagagatt gattaaacag cttgatggat tcaagattat cggcaaggcg 782221 gctaacgcaa aagagacatt ggcgcttttg aaggaacaca aggctgattt gcttctgctg 782281 gatatttata tgccggacga gcttgggacc gcgttgattc ctgatatacg aagccgattt 782341 cctgaagtgg acattatgat tatcacagcg gcaacagaaa cccgtcattt gcaggaagcg 782401 ctaagggcgg gaattgccca ctatttgatc aaacccgtaa cagctgacaa gttcaggcag 782461 gtgctgcttc agtataaaga aaaaaggaag ctgctcatgt ctcagccgga ggtcagccaa 782521 tccatgatcg accatatttt tgggaacggt gtgaagacag ctttgccggc agaggatttg 782581 ccgactggca ttaattcgat tacactgcga aaaattaagg aagcgcttca gactgcgtca 782641 gaaggattga cagcggagga acttggggaa aaaatggggg cgtcacgaac aactgcccgc 782701 cgttatgccg agtaccttgt gtcaaaggaa gaagcaagag ccgagcttga atacgggatt 782761 atcggcaggc cggagagaaa atattatttg gcggcggatt agatatgaaa aaatctataa 782821 tcctattgaa tattctattg atctttatgc agggtgatat caggcaggcg gctgcgccgc 782881 gcctgccgga cgggccgata gaaattgtcg tccctgccga accttctggc ggctgggatg 782941 tcacagcgca ggcgatccaa tcagttttga ggcagaagca gatcgtgaag gatgatgttc 783001 atatcgtcta taaatccggc ggcgggggag agaaaggctg gaaatatgtc aacaaaagca 783061 gcaaacaaac catcagcatg acgtccagcc taatattgag caatgatctt ctcgggcaaa 783121 gcaaattaaa aatgtccgat tttacgccgc tcgccattct ctccaaggaa tggcagacgg 783181 ttgcattgcc aaaaggatca gcgttaacaa atggcaagga tgtgctgaat gagatcaaca 783241 tgcatcccgg caaggtgaga atcggctttg ccccggggtt tggcaatgat gatcagctct 783301 cgttcgtcag agcggcagat atgtacggca ttgacccgtt tgacattcaa ttctcacagt 783361 atgacagcag cgaacagctc attcaggcgc tgatcagaca tgagatagaa gcggcttcca 783421 tgacactttc tgaagcgaaa ccatatgaac gaaacggcga tatcacgtta gccgctgtaa 783481 cgtctgataa aagacttccc ggttttccaa atgtaccgac gtggaaggag cagggaatcc 783541 cgtttgtttt ttctcattgg agagggattt tgggcccgaa aaatatgtct gaggaagaga 783601 tttcttactg ggatcaagcg ctaaagaagg tcacctcctc acctgaatgg aagcggaaaa 783661 taaacgaaca ggactgggaa agcttttatt taaacagcag ggaaacgaaa cggtttttag 783721 aagagcaatc tgctttttat caaagcatca tgacaggaaa ttaaaatccc gacatcccgg 783781 gatttttttc atgccgaaaa ttgatcaaaa agaacaaaac ggttttaaaa aattaaaaat 783841 acaaaaaaac caaattattt acttgcggtt ggttttccca tacgatggca aaaaggcaag 783901 acaaaaaggg gagtaaggga gaaaaaaatg taagcggatt catttaaggg ggaatggatg 783961 tgttagcaat cttaggcttt ctcatgatgc ttgtgtttat ggcattgatc atgacaaaac 784021 ggctttctgt tttaacagca ttagttttga cgccgattgt gtttgcgctt atcgccggat 784081 ttggatttac tgaagttggg gacatgatga tttcggggat tcagcaagtc gcgccgactg 784141 cggtcatgat tatgtttgcg atcttatatt ttggaattat gattgataca ggcctgtttg 784201 atccaatggt tggcaaaatt ttaagcatgg tcaaaggaga ccctttaaaa attgttgtcg 784261 ggacagcggt tcttacaatg ctcgtcgcct tggacggaga tggctcgaca acgtacatga 784321 ttacgacaag cgccatgctt ccgctctatt tgctgctagg catccggcca attatcttgg 784381 caggaatcgc gggagtcggc atgggaatca tgaacacgat tccatgggga ggtgcgacgc 784441 cgagggcggc gagtgcgctg ggggttgatc cagctgagct tacagggccg atgattcctg 784501 tcattgcaag cgggatgctt tgtatggtgg cagttgcgta tgtgcttgga aaagcggaac 784561 gaaagcgcct tggtgtgatt gaactgaaac agccagccaa tgccaatgaa ccggctgctg 784621 cggttgaaga tgagtggaag cggccgaagc tttggtggtt caatttattg ttaacgcttt 784681 ctttaatagg atgtttagta tcgggtaaag tcagtttaac cgtactgttt gtcattgcgt 784741 tttgtattgc gctgattgtg aattatccca atctcgagca tcagagacag cgcatcgcgg 784801 cgcattccag caacgtgctg gctatcggtt caatgatttt tgctgcgggg gtgttcacgg 784861 ggattttgac aggcacgaaa atggttgatg aaatggcgat ctcgctcgtg tccatgatac 784921 cggaacaaat gggcggattg atcccggcga ttgttgcctt aacaagcggc attttcacat 784981 ttttgatgcc gaatgacgcg tatttctacg gggtgctgcc gattttatca gaaacagctg 785041 tcgcatacgg tgtggataaa gtggaaattg ccagagcctc tattatcggc cagccgattc 785101 atatgctgag tccgcttgtg ccatccactc atttgcttgt cggactcgtc ggagtttcta 785161 ttgatgacca tcaaaaattc gcattgaaat gggcggttct cgcagtgatc gtcatgacgg 785221 ctatcgctct attgatcggt gcgatctcta tttccgtatg ataattcagg cgtaatgaca 785281 cacactaacg gcatacaaca ttccggaggt gtcattatga gtgatcctta tatgccgctg 785341 acttcagtca gaagcggagc ggggttcgaa gcggcaaaag gggtgcacgg cctgactgtg 785401 caaattgcga atgtctattt tattcagctg ccttctgaac ctcactcatt tgttttaatt 785461 gatgccggca tgccccaatc agccggcgtg attgtcaatg aagccaaaca aagattcggt 785521 gaagggtttc agctgaaggc gattatcctc acacacgggc actttgacca tattggggca 785581 atcgaagaga tccttgagca ttgggatgtg cctgtttata tccattctcg ggaaatgcct 785641 tatgtaacag gtaaagagga ttatcctccg gctcgtcctg acagcaagag cgggctggtc 785701 gctaagctgt cgccgctgtt tccgcggcac tctatcgata tttcctcaca tgtccaggca 785761 ctgccggaag acggttcagt tccttttctt gacgagtgga tgtggatcgc gacaccagga 785821 cacacgccgg gccatatttc gttattccgc gatgacggcc gcgtgcttgt ggcaggtgat 785881 gctgttatta cagtggaaca ggagaaaatg gctgacgtct tgatacaaaa acaggagctt 785941 cacgggccgc cggcttattt cacgcctgac acagagacgg ccgctgagtc cattctaaag 786001 ctggccggtc ttgaaccgga agcgttattg accgggcacg gcataccgat gaccggcaaa 786061 aactttcgaa gtgacttaac tgaattggca aatcggttat cgtctatttg acacccgcac 786121 cacgcgggtg ttttttattg ttttccagga agttgcagaa aaatcatttg tcttgccgct 786181 taaaaacgat acaatgaaaa gcatgaagtg atgtgaaggg gagagtttgt tggaagaaaa 786241 agaaatactc tggaacgaag cgaaagcgtt tattgccgca tgctatcagg aattgggaaa 786301 ggaggaggaa gtgaaagacc gtctcgcgga cattaaaagt gaaattgacc tgaccggaag 786361 ctatgtacat acgaaggaag agctggagca cggagcgaaa atggcttgga gaaacagcaa 786421 ccgctgcatc ggcagattgt tctggaattc gctgaatgtt atcgacagac gagacgtccg 786481 gacgaaggag gaagtgcgtg atgccctctt tcaccatatt gaaaccgcca ccaataacgg 786541 gaaaatcaga ccgaccatta cgattttccc tccggaagag aagggtgaaa agcaagtcga 786601 gatctggaat catcagctga tccggtacgc tggatatgag tcagacggag aaagaatcgg 786661 cgacccggct tcctgttccc tgacagcagc ctgcgaagag ctcggctggc gcggagagcg 786721 aacggatttt gacctgctgc cgctcatttt tcgcatgaaa ggggacgagc agcctgtctg 786781 gtatgagctg ccgcgttcac ttgtgattga ggttccaatc acacatccgg acatcgaggc 786841 gttttctgat ttggagctga agtggtacgg cgtgcctatt atttctgata tgaagcttga 786901 ggtcgggggc attcattata atgccgcgcc atttaacggc tggtatatgg gcacggagat 786961 cggagcgaga aacctcgcag atgaaaagcg gtacgacaag ctcaaaaaag tagcgtccgt 787021 gatcggcatc gccgctgatt acaatacgga tttatggaag gatcaagcgc tagttgaatt 787081 gaataaagct gtgctgcact cgtataaaaa gcagggtgtc agcatcgttg accatcatac 787141 agcggcaagc cagtttaaac ggtttgaaga acaggaggaa gaagcgggca gaaagctgac 787201 gggggactgg acgtggctga ttccgccaat ttcacccgct gccactcata tcttccaccg 787261 ctcctatgat aactcaatcg ttaagccgaa ctatttttat caagataagc cttatgagta 787321 aacaatagaa aatcgatgat ggccttcaag gctgcgggat tcagtcacag agatgtcggt 787381 aacctttgag aaagggcttc cgttctttac agcctcaaca aacgattgca gggcgttttc 787441 cggaccctct gccaaaatct cgacacgccc gtcatcacgg tttttgaccc agccggccag 787501 ttttcgctta tcagcttcca tttgaacaaa atagcgaaag cccacacctt gaacccggcc 787561 gtctacaatg attcggtatt gaagcatgta aaaaccacct tttcttttta tgataatcaa 787621 tcattttaca acctgtaaag gggatgtgtt tgtatgaaac aagagcgcta ttcagttctt 787681 tctcttaatc tgggaaaacc gcagacgctt gaatatgacg gaaagaaaat cgaaaccggc 787741 atcatgaagc ggccggctaa atcagccgtc atgctgtatc gggagaattt tgaaggagac 787801 ggacaggcgg acctcgtcaa ccacggcgga cctgataagg ctgtctgtgt ctacccggcg 787861 gagcattatc cgttttggga agagttcctc tcaagaccgc tgtcaaatgc cgcatttgga 787921 gaaaatctga cggtcgcggg cctgactgag gagaatgttt gcatcgggga tgtgttcaga 787981 cttgatgaag ctgttgttca ggtcagccag ccgcgccagc cgtgtgtaaa gctggcgaaa 788041 aagtttggtg taaaagaaat ggtgctgaag gtccagcaaa ccggctatac agggttttat 788101 tttcgcgtgc tggaggaggg cagggtgtct cccggcgcga accttgaatt gctgtccaga 788161 ggagagaaag gcatatccgt ccagttcgcg aaccgcatca actaccatga tgcaaaaaat 788221 ctcaccgcca ttgaacggat tttaagtgag gctgcactat cggaaagctg gagagcgtcc 788281 tttatgaaaa aaaaggacag gctgctgccg gttgaataga aaaaagccgc gcatatcaac 788341 gtgcgcggct ttgccatatt taagattgtt ttttctttga ttcaagcagg ttggcaagaa 788401 aataggtttt atagctttga agctttcttc cttcatggtg cgtgatcccc tgctttttta 788461 gttctgccac ataccagcct ttactgccgt aatgcatgtc agaaaactcc tttccctatc 788521 tgatttcgaa acgattggca ttgtaacatc tataaaaaga tgctgaaaag agatgcgggg 788581 aaaactgagc ctttcgcact agatgtacga atgttcttct gaatgtatat gcggagcaaa 788641 agccgaatat gatttaatgg ccggttagtt tgatcatgac aacgccaaat gtcataatgg 788701 cgaaaacaat gccgatatat gtgagcatcc cgtttttttt cttaacgccg taaacggtca 788761 taatgatgcc ttcaatgaaa aaaatgatgc cgaaaataat aaaccacatg cagataaagg 788821 ctcctttcac agacataata gtagtgtagc atatctgaaa gagccgggct gtgacaatat 788881 caagaaagcc gggcgcatat cgcccggctc atgttttatt gtttatcaac caatttgacc 788941 agaagctgtg ccaaatgttc tttctcatct tcgtctgcaa cgctccaaag ctcttgcagc 789001 agcatttctt caccgttttg cggctcttca tgctttgcga ggtagtctcc caggatcgca 789061 gcgcttttta caagcttgcc gtcatccaat cccagctttt tgcctcggtt gacttgtttt 789121 ttcaggtagc ctttaaattc ctcaaagtct tttaaaatgt cttcttttat tgtgccatgc 789181 atcgcgttca tttcgttttc aatttggatt ttttcttgat ctctgttcat tgcaagacct 789241 cctcgtacag aataatgatg ctttacctgc aattggagga ggttaaacct gccggaagcc 789301 cggaatgtgt tttacagttt cgtcaggata atcggttcat cttttgtgat gacgatcgtg 789361 tgttcaactt gggcaaccat gcttttatcc ggcgtcttga acgtccagcc gtctccagct 789421 tcaacaatcg tttctgcttt cgttgaaata aacggttcaa gcgcgatgac tgtgccattt 789481 ttgaacagcg cattatcaaa cggatcataa tagttcatga tgtggttcgg cgcttcatgc 789541 aggcttcggc cgattccgtg gccggtcagg gttttgatga cggtaaagcc ttgagagcgt 789601 gcttcatgat aaacggctct tccgatctgg ttttggcgct tgcccgcttt tgcctgctga 789661 agcccctttt gaaaagcgtt ttccgcgcat tggcaaagct tatgaaggcg ttcttctcct 789721 tcaccgagca caaatgagat gcctgtgtcg gaatagaagc cgccaaattc agcggagatg 789781 tcgatgttga caaggtcccc tgcttttaaa attttggatg tgcttggtat gccgtgagcc 789841 acttcatcat ttacgctgat acatgtcaca cctggaaaat cgtattcctt ctcaggagct 789901 gaaacggcgc cgtgctcatc aagcacagct tttccgataa ggtcaaggtc ttttgtgctc 789961 atgccgggct ctgccttccg cttcatttct tcacgcgcaa gcgcgacgat tcttccgatt 790021 tttttcaggc cttctaattc ttgatcgttt gttacaatca tctgtcattc ccgctttctt 790081 tttaaataat ctagattaag cttaccacaa ctgtcttaaa aataggaaac acacggacct 790141 gggaaaaaag aaataccccc gggaaaattg gtatagatca ctagatatct tatatggtat 790201 atttgaaaaa aaagggtatg agggggatgg gtatgctttc atttttacaa aaactcggga 790261 agtcatttat gctcccgatt gcggttctgc ctgcggttgg aattatcctt gcgcttggca 790321 gagaggatgt atttaatatc ccgtttgtct atcaggcggg gacggcggtt tttgatcatc 790381 tgccgcttat ttttgcgatc ggtattgcca tcggcatttc aaaagacagc aatggggcag 790441 cgggtttatc aggggcgata tcgtatctga tgcttgacgc ggcaacaaag acaattgata 790501 aaacaaataa catggcggtg tttgggggaa ttattgccgg tttaattgcc ggttacacct 790561 ataaccgctt caaggatacc aagctgcctg aatatctcgg gttcttcagt ggcagacggc 790621 ttgtgccgat tttaacagcc attattacga tcattttagc gggcatattc ggagtggtct 790681 ggccgccgat tcaatcgtgt atcaactcgt ttggagagtg gatgctcggg ctcggcggca 790741 tcggggcagg catattcggc ctattcaaca ggctgttaat tccgcttggc cttcaccatg 790801 tgctgaacaa tattttctgg ttccaattcg gagaatataa cggagtgaca ggggatttgg 790861 cgcgcttttt cgcgaaagat ccgactgcgg gcacatatat gaccggattt ttcccaatca 790921 tgatgttcgg tcttccggcg gcgtgtctgg ctatggttgt gactgcgaag ccgtctaaac 790981 ggaaagcgac ggctggaatg atgattggat ttgctttaac ggcgtttatc acagggatta 791041 cggagccgat tgagtttgca tttatgtttt tatctccgct tttatacgct gttcacgcgg 791101 tcttaaccgg gttatcttta tttatcgtca actggctcgg catccgctca ggcttctctt 791161 tttcagccgg agctatcgat tatgtgctca gctatggaat cgcggaaaaa ccgctgcttc 791221 tgcttttggt aggtatatgc tatgcggcag tatactttat cgtgttttat gtactgatta 791281 aggctttgaa tttaaaaacg cctggacggg aagacgatga tgtggatgaa gtgctggatg 791341 aaaatactgt tcaggatgta aatgaaaaca tcatgctgaa agggctcggc ggaaaagaaa 791401 accttcaaac cattgatcat tgcgccacaa ggctgcgact gactgtgaag gataccgctt 791461 tggtggatga agcactgcta aagaaagcag gcgcaaaagg ggttgtcaaa tcgggcgggc 791521 aatcggttca agtcattatt ggcccgaatg tggaatttgc agctgaggaa ttgagggctg 791581 ctgtcaaata aaaaagcgga gagggcaacc tctccgcttt ttcttattta tcttcgttat 791641 cctttgacgt ttcggaagaa tcttcgtcat gttttgtgta atcataatca gaaggattca 791701 ccttcttaaa acctttcggc tcgtagaacc gcagcaggtc tccgtttatg attttatcgg 791761 acatttcaag ttccttcttg acgagtgagt cttctgactt gtcgacttcg gattcatcga 791821 gttcttttcc ggttttcgtg tcgtaatact taccggatat tttcgtgtac ttcggtgaaa 791881 taaagtctcc gtttcggaac ggaatcactt cacggtgttc tttcgataaa atatcagaac 791941 cggacatcag atagtccttc gtatccactc cgagcagatg cagaatggta ggagccacat 792001 caacgtctcc ggcatattta tgaactttct cgcccttcac gccggcagcg tggataaaga 792061 gcggcacccg ttgaagctgg gcgttgtcgt aatcagtgat ttcatccttg ccaagcactt 792121 tcgccatcgc tttattgtgg ttttcagaga tgccgtagtg gtctccgtac atcacaataa 792181 tcgatttatc atataacccg tcttttttca gatcattgaa gaattgttca atggactgat 792241 caaggtaatg ggctgactgg aaatagttat cgacgacaga gtcaccaaag tctccagccg 792301 ggaagtctgt atccccctca tccattccga atgggaagtg gttggaaagg gtaatgaact 792361 tcgtatagaa cggctgcggc aggctttcca gcagcggcat tgattctttg aagaacggtt 792421 tgtctttcat gccgtagttt ttcgtgtttt cttcgttcat gtcatagtaa gcagaatcaa 792481 agaatttatc aatgccttcc gccttgtaca tttcgttacg gttccagaac gtctgcgtgt 792541 tcccgtggaa agtagcagat gtgtaattct tagacttcag aatcgccgga acggattgca 792601 gcgtgttttg cgctttgttt acgaaaactg aaccttgagc cagcgggtac agagagtttt 792661 ccatcataaa ttcagcatca gatgttttac cttgtcccgt ttggtggaaa aagttatcaa 792721 agtagaacgt ttcgttatca tgtgccagtt tatttaagaa tggtgtcact tctttgccgt 792781 caattttata gtcgatgata aatgactgca aagattcaag tgaaacgtaa atgacgtttt 792841 ttccttccgc tttgccgaaa tacacgttat tcggcacatc gtaattggct ttcatgtagt 792901 tttctacttc cgttacgtcg ctggaatcgg caagcgcgcg ctggctgttg gacttgatat 792961 tctgtacagc gtcataaatc gtgaaattgt atgttcccaa gtatttcaca agatagttcc 793021 ggtcgaatga tcttgtcagc aattcaggac ggtctgattc cgcaactgcc aggttgatca 793081 agaacacaag aattgaagac gcaaaaataa ttcggaacga ttttttgctt gacgtttcgg 793141 caggcttgtt tactttgatc gccaagatga tcaggatgat cgtatcgata aagtaaaagg 793201 cgtcagtcgg tctcatcagc gaaaatgcgc tgtcaccgag ttggccgccg tttgttttag 793261 cctgcataat gaccggaatt gtaataaaat cattgaaaaa tctgtagtac acaatgttgg 793321 cgtacagtaa aaaagacatt aaaaaatgaa tcactataat ggctgtctgc tgtaattttt 793381 tcttgaacaa gagtccaaag ccaagaaaga acaagcttga gctaagagga ttcacaaaaa 793441 gcaatatttt ttgtatcgtg ttgtctattc ctaagttgaa attcaggaca taaccgacat 793501 acgttttgat ccataacagg acgaccgcaa ttaagaagaa ggccagtcct ctttctttta 793561 taaatgtttt cattgttaca ctcctttttt ccgatccagt tcgagcgaaa cgatagaaaa 793621 aacgaacgta tccaatataa cacgaatcag cagattagaa aagtgaaaat cgtatgaggg 793681 agaaagtggc gaaaaacgcc gtcgaatcaa cgtttcgctt tgatattacc aaatgtaaaa 793741 caaggtatct ttctagaaat aaaggaataa aatggtacat tgagaattgt atgataaaat 793801 ataaggtata gataaaaaga ggtgaaatga tggatttttc ccatattgtg tctgaagata 793861 aaattaagcg cgccatcaaa gacggggact ttcaaaacct cccgggaatg gggaagccgc 793921 tgccgaagga tgacgcggca cacttgccgg aatcgctgcg catgggctat cgtattttga 793981 aaaacgcggg aatggcagag gacgagggcg cgctcaaaaa agagcttatg accatcgacc 794041 atttaatcga aaagtgctat gacgaaaaag aacgcgagca attaatcaga aaaaaatctg 794101 aaaagcaatt gctgcttgat aagcttgtcg acaaaaaagg catgttttca aagccagcat 794161 ccgcttttta taagaataaa gtatatgacc ggcttggacg aaacagacct tcttccagct 794221 gatttgtctt gtctgcagga tggcgattga taaaagccat cctttttatg ttccaagttc 794281 tatgtcaaaa ggtttatgtt tttccatcta tgggaaatga ttcataaacg aaaaaagggt 794341 gatgggatgg aacgactatt agtatggata gagcatatat ctgattggct gtggggtccg 794401 ccgctaatca tcctgctgac ggggacgggc ttgtatttca ctattttgct gaaaggtttt 794461 caatttcgct atcctttata cattttcaaa cagacaatcg gcagtgtagg aaaaaagccg 794521 aagggagaag gcacagtcac accgcttcag gcattgacct cagccctcag ttcaacgatc 794581 ggtgcagcga acattgtcgg tgtgcccgcc gctattatgt ttgggggacc aggagcggtt 794641 ttttggatgt ggcttattgc cttatttgcc atggcgatta agttttctga aagtgttctt 794701 gctgttcatt acagagaaaa aaatgagcag ggtgaatacg tcgggggacc gatgtattac 794761 ataacaaaag ggctgcgcat gaaatggctc ggcgtattct tctctgttgc gctgattgtg 794821 gagctgattc ccagcattat ggttcaggga aattcggttt cagtctcgct tgccgagacg 794881 ttttctttca ataaaatata cgcaggaatc ggaattgcat ttttgattgg gttagtggtg 794941 ataggagggg taaagcggat cggaaaagta acagagtttg tcgtgcctct tatggcaggg 795001 gcatacgcag gtgccggtct cctgattgtt ctcatgaatc tatcatcagt gccggcgttt 795061 ttctctctcg ttttttcaaa tgcgtttacc tcttcttcag cagttggagg gttcgcaggt 795121 gctgcgttgg cggaaaccgt tcgctgggga tttgcccgcg ggctgtattc taatgaagcc 795181 gggatgggaa cagccccgat tgcacatgcg gcagcaatga ctgatcatcc tgtgcggcaa 795241 gggttttggt ctgtgatcgg cattgtcatt gacaccttaa tcatctgtac gactaccgct 795301 tttatcgtcc ttgcatccgg tgtatggaca gggaagaacg cctcaaatga cccggcagca 795361 ctgacaacgg ccgcatttca gcactatttc ggttctggag gaggatactt cgtttcggtt 795421 tccctggtct tctttgtcgt atcaaccatt atggttgtca ttttttacgg cgtaaagcaa 795481 gctgaatttc tgttcgggcg gctggcagga catgtgatta aattcgttta tttagcggct 795541 attatcatag gtgccgcagg cggagcaaaa gccatttggg gcgtattgga cttagcattg 795601 gtttttattg ttgtcccgaa tgtgattgcg ctcttgttat tgagcagaaa ggtaaaagcg 795661 ctgtacaccg aattctttac atctgaacag tactacctga aagatataag aaaaacgaaa 795721 caaaagcctg tttatccaac aaaagaagct aaaaattcct agtgttttgc ttttgcgccg 795781 aacaatgctt tgctttttat gatcaaataa atgagtaaag gcagcaaaag agaaatcact 795841 acattaatga ttggtttgat tctgttaaag tcgattagct gatttgtatt taaaaaaaac 795901 caaaagccgc atacgactga gaacatgccg gttggtgtat acatggcttt cgggtcgatt 795961 tttgagtgta aaaacgaaag gccgtatacc acgatatata gggaacctgc tatcttcacc 796021 ataatgaccg gaatccaaaa agccgcgatg atcaggtctg agcgatccag aaaatccgta 796081 atgcggatct gcctgatgac catataagca ggatcaaaga aagtagatgt caggttggga 796141 ccaaagacag aaattgaaga aaataacatc acggccagca ataaagcgcc cagcagtatc 796201 gcgaaaatgg tgtattttag cgggacgctc cggtttgaga agagaagcgg aaggataatc 796261 aattccccca ttgtcccaaa cgcgtaatag cctgattgaa ggtatgggat tagaccttca 796321 aaaacaggtg tcaagttttg aagctcaatt tgtgtggcca gcgtaaatgg aaggaacaag 796381 accaggatgc cgaatggaaa taggaatatc tgcgccattc tggtcaatgt ttcttttccc 796441 tctctggcaa tacagatcgc cacaaagata ataacaccgc caagaacagc cattggtgtt 796501 ctcgggagaa ataaaatgtt aatcaaattg atgaaaaaac gtatatcatg agcattgatt 796561 aacaggaaat acaaagaaaa cagtaaaatg ataatccggc ctgcgattgg tgaggaatcg 796621 ctcagcagct catagatatt tttatcctga tgctttttca tcagcctatg catgagccag 796681 agtgccggaa tcacgatgac aacgccgagg atgtagctgt gccaggcatt ttgttttgct 796741 gattcgatca tgagaatcgg agcatgcttt aatccgactg ctaacgtata cagagctccg 796801 aaaaataatc cttggtatgc agaggtcttg tccataaagc acatcctttc tgtcatgttc 796861 aaaacggaat atatttaaac aggtgcccca gccgcggaag caggggattc actctcatat 796921 aaatccatag aaaagcactt cctgcaatta gcaggctgaa ggcccatttt gttagattgt 796981 tagcggaacg aaaattcttc cattcatatg cgtatatggc aatgcacaca atcaatgtct 797041 gtacgatata gctgatcatg ctgacgcacc tccattaatg gctgatcgtt ttgtatagga 797101 caccgccctg ctcaatcgtc acaattggga cgacgtgaac ctccatatcc ttatatacct 797161 cttcccattc ctttttcagc agattcttcg tggttgccgt gcttctgatg gtcctgtctt 797221 gaaagccggc cgggtccgcc tttagctttt gcaaacgatg aacggtgctg atcacgtcct 797281 tctttatggt tctgtttaat gctttttgaa tgatgtaata ctggtcattt tctctcgtct 797341 cataggttga ttggttttcc ataataattc ctttggctct gatctcgatt gtcattgaca 797401 gctttccgtt tttttcagcg gcatgaaagg atgcattgga cttttgaagc tgaatggatg 797461 cttgccccat ttgattcggc aggtctacta tgaattctgg ctggcgggct tgattcagca 797521 acatcagggc tgctgtcatg tgttcatctt tgaaaatatc catcaatctg tcctttttaa 797581 agatcgcaag cccgtcaatt ttcaaattag atttgccttt ccctccaggt tttgttttag 797641 atgcagagat gaccggtgca tacggatcac tgcctatttc tactagatca gacatgaatc 797701 tgcttaagaa aacggggcgg ctcgttgcga taatggccag ctcccgaatc atttccgccg 797761 gaaactgttc aagctgaaca tcggtattta aaatgtcccg cgcttctccc cggctgacta 797821 aaatgagcgc cgttaatctg ttctgcggat ttcgcgttaa aatatcaaag actggggcaa 797881 cgccgtctct cgccatatcc tctccaataa tgactgtacg tctgtgggac gtattgattg 797941 tccgtgacaa ggaggtttgc agcttgttgt tcgcttctct gatcgtagtg ccggaagctg 798001 aatcaacata ccatgttttt gaaccggcag ttccgccgcc gccccctgtt tgtccgccta 798061 attggccgac caagggaatc tgcatggcca ctcgatactg atcttttttc ttatcaatgg 798121 ctgagctgac aacaaatgca atgtcattga tttctgtccg gtcccagcac cccgttagaa 798181 ggatacaaat gagaagcggc aaaacacact tatatattgt tttcttcatc ttttgggtcc 798241 tctcttttcg ctcccttctg tccgttgccg cgcgaatacg tgcccggcct tctggtcatc 798301 gtccaccaag gcgccctgac aaaaatatct tttacttcat ctcgtttaaa cggagaaatc 798361 ccggataaat aaggaatgcc gaaagattgc agcttgcata aatgaagcac taagataatc 798421 gtgccgagca taatgccgaa tatcccaaaa atactcgcca aaaacataag cgggaaacga 798481 agcatcctga tggagatagc taagttaaac cgcggaattg taaatgacgc gatccctgtt 798541 aacgatacga tgatcaccat gggggcagac acaattcccg cttcaacagc ggctgtccca 798601 atgactaggg ccccgagaat actgacggtc tggccgatgg ttttcggcag gcgcactccc 798661 gcctcacgga gagcctcaaa agaaatttcc ataatcaatg cttctatgat ggcggggaaa 798721 ggaatcggtt cacgcgcaga ggccacactg aacattaagt ttgtcggcat taagtcctgg 798781 tggtatgtaa taacggcaac ataaatagcc ggcaaatata aagcaacgaa taaaaacata 798841 tagcgaagcc agcggattaa gttagacatc aaataacgct catagtaatc ttcactggcc 798901 tgcataagct gccaaaacgt aatcgggcct gttaagacaa agggcgtatt atctgtgaaa 798961 atggcaaatc ggccttcgag aagctgggcg gcgacggtgt ccggcctttc tgtgtattgc 799021 agctggggga atggcgagta cgtgtcgtct tcgataaatt cttcaatata tccgctttct 799081 aagacagcat caatctttat ctttttgatt cttttttttg ctttgtcaat aacctttgga 799141 tcggcaagcc cgtcaatata ggccaagaca acatcggttt tggttttcgt gccgatttta 799201 aaagagatca ttttaagctg aaacgttttg acgcgaaagc gcacaagagc ggtattgacc 799261 ctgaggcttt cagtgaagcc ctctcttgac cctctgatgg tcgattctgt tatcggctct 799321 tcaatgcttc ttctttgtcc gccttttata tttaagatca ggccttttga gtgcccgtcg 799381 gcaaataaaa ccgcgttccc ctcaatgatg gatgcagcca ctttgctcat actcgtttct 799441 aatgcaacac ttgaaattga tagagtattt tgcagcgcct cttcatgttc atctatttga 799501 tccgtcaaat gcattaagaa agggcggagg gcgtgatcct gaatatgttc agattttaca 799561 attccttcga tataaacaat aaatccgcac agcccgtttc caaagtcaaa ttgtctaaat 799621 acgatgtctg agcagccttc tgttaataag gtcagatttt cgaggttttc cttcaaattg 799681 ggagagatcg gtctgtcctg attgtcttca agctctttga tgagctgaag cgctttgtcg 799741 cgtttattca tagaggctca ccctgctttt taatgtcata ttcaataagt gcttgtgact 799801 tttagggtaa ccttgtctgt ttcatatatt ccagactagg atgaaagcgc tataaaaaag 799861 tgttgactac ctgtatatac aggaatacaa tatgattata agttgtatat acaagttata 799921 aaaacggata cggaggggtt ggcatggggg aactgaacaa atcggcacgt cagattgtcg 799981 aagcagtcgg cggtgctgaa aatattgcag cggcaactca ttgtgttaca cgtttgcgtt 800041 ttgctttaat agatgaaagc aaggttgacc aagagatgct tgatcaaatt gatgtggtaa 800101 agggatcatt ctcgacaaac ggacagtttc aggtcgtaat cggccaggga actgtcaata 800161 aagtatatgc tgaactggtt aaggaaacgg ggattggcga gtcaacaaag gatgaagtga 800221 agaaggcctc agaaaaaaat atgaatcctt tgcagcgtgc tgtgaaaacg cttgcagata 800281 tttttattcc aatattgcct gcgattgtca cggcgggtct tttaatgggg atcaataaca 800341 ttttaacggc ggaaggcatt ttcttcagca caaaatcgat tgtgcaggtt tatccgcagt 800401 gggcggatct tgctaatatg attaacctga ttgcaggcac ggcctttacg tttttgcctg 800461 cgttaatcgg atggtctgcc gtcaagcggt tcggcggcaa tccgcttctc ggcattgtgc 800521 tcggggttat gctcgtgcat cctgatttgc tgaatgcgtg gggatatggc gcggcagaac 800581 aaagcggaga gatcccggta tggaatctat tcggcctaga ggtgcagaaa gtcggctatc 800641 agggccaggt gctcccaatt ttgcttgctt cttatatgct ggcgaagatt gaggtatttt 800701 taacaaaacg cacacctgag ggcatacagc tgctcgttgt cgcaccaatt acgcttctct 800761 taacaggatt tgcctctttt atcattatcg gcccgattac atttgcgatc ggtaatgtac 800821 tgacttcagg gcttatctcg gtgtttggtt cttttgccgc actgggcggt ctgttatatg 800881 gcggtttcta ctcagcgctc gtgattaccg gtatgcatca cacgtttctt gcagtcgacc 800941 tgcagctcat cggttcaaag ctcggcggca cctttttatg gccgatgctg gcgctttcta 801001 atatcgcaca aggttcggcg gctctggcca tgatgtttat cgtgaaggat gagaaacaaa 801061 aaggcctctc cctcacatca gggatttctg cttatcttgg cattacagag cctgccatct 801121 ttggggtgaa tctgcgatac agattcccgt ttatcattgc aatggtcagc tctggcctgg 801181 ccggaatgta tatttcttct caaggtgtgc tggcaagctc cgtcggtgtc ggcggcgtgc 801241 cggggatttt ctcaatcatg agccagtact ggggcgcgtt tgcaatcggg atggctattg 801301 tattgatcgt gccgtttgcc ggaacatacg cgtatgcgag attcaaacat aaataacaag 801361 tggggagcgg gacgtgttga acgttccctt ttcccgtttt caatttaaat atggtggtgg 801421 aaacagatga aaacagaaca aacgccatgg tggaaaaaag ctgtggttta tcaaatttat 801481 ccgaaaagct ttaacgatac gacaggaaat ggtgttggcg atctgaacgg cattattgaa 801541 aagctggatt acttaaaaac gctacaggtg gatgtgcttt ggctgacgcc gatttatgat 801601 tctccccagc atgataatgg gtacgatatt cgtgattatt actcgattta tcctgaatac 801661 ggaacgatgg aggattttga gcggctagtg tccgaagcac ataaaagaga cctgaaagtc 801721 gtcatggatc ttgttgtcaa tcatacgtca acagagcaca aatggtttcg cgaggcgatc 801781 tcttcaatag acagcccgta ccgtgatttt tatatatgga aaaaaccgca ggaaaacggt 801841 tctgttccga cgaactggga atcgaaattc ggcggctcgg catgggagct tgacgaagca 801901 tcgggccaat actatttgca tctgtttgat gtgacgcagg ctgatttgaa ttgggaaaat 801961 gaagaggtca gaaagcatgt ctatgacatg atgcattttt ggtttgaaaa gggaatagac 802021 ggctttaggc ttgatgtcat caacctgatt tctaaagatc agcgctttcc gaatgcggag 802081 gaaggcgacg gccgctcttt ttacactgac gggccgcggg tgcacgaatt tctgcatgaa 802141 atgaacgaaa aggtgttttc acattacgac agcatgacgg tcggtgagat gtcttcaaca 802201 accgtagacc actgcatccg gtatacgaat cctgacaata aagaacttga tatgacattc 802261 agcttccatc atctcaaggt tgactatcct aacggcgaaa aatgggcctt ggcgccgttt 802321 gattttttga agctgaagga gatcctatct gactggcaaa cggggatgca cgcaggaggg 802381 ggatggaacg ctctgttctg gtgcaatcat gatcagccgc gcgtcgtatc aagatatgga 802441 gatgatggcg catatagggt gaaatcggcg aaaatgcttg ctacggccat tcatatgatg 802501 cagggcacgc cttatattta tcagggcgag gagctgggga tgacgaatcc gaagttcact 802561 gacataagct cctatcggga tgtcgaatcg ctgaacatgt atcacgcctt taaggaaaaa 802621 ggaatggctg atcaagatat tacagccatt ttacaggcga aatcccgtga caattccaga 802681 acccccgttc agtgggatgc tacggaaaat ggtggtttta caacgggcac accatggata 802741 ccggttgcag gaaattaccg ggaaatcaat gctgaagcgg cgctgaggga tcagaattcg 802801 gtgttttacc attatcaaaa attgattcag attcgcaaaa tgtatgacat tgtgacagag 802861 ggtacgtatg agataattgc aaaggatgac ccgaacattt ttgcgtatct cagacacggc 802921 agcaatgaaa agctgctcgt gatcaataat ttttacggga cagaggcggc ctttacactg 802981 ccggactctt tagcgcctga cgaatggaag gcagaggtgc tgttgacgaa cgatgaagca 803041 agggaagggc ttcagaacat gacgcttcgc ccatatgagt ccattgttta tcgtttaacg 803101 aaaccgtgtt aaactaagct gggtggtcca taatgaaggt gaataaattc atcacaattt 803161 ataaagacat cgcacagcaa attgaaggcg gccgatggaa agcggaggag attcttccgt 803221 ctgaacatga gttgaccgca cagtacggta catcaagaga aacggtccga aaggcgcttc 803281 atatgctcgc gcaaaacggt tatatccaga aaatcagggg aaaaggctcc gtcgtgctca 803341 atcgtgaaaa aatgcagttt cccgtttcgg gccttgtcag cttcaaggag ctcgcgcaaa 803401 cgcttggcaa agaaacgaaa acaactgtac acaaattcgg gctggagcct ccgtcagagc 803461 tgatccaaaa acagctccgg gccaatctgg atgacgacat ctgggaagtc atcaggtcta 803521 gaaagattga cggggaacat gtgattttgg acaaggatta ctttttcaga aagcatgtcc 803581 ctcacctgac gaaagaaatt tgtgaaaact ccatatatga atatatagaa ggagagctcg 803641 gtctttcgat cagttacgcc caaaaagaaa ttgtagccga gccgtgtacg gacgaggaca 803701 gagagctgct cgatttacgc ggctatgacc atatggtcgt ggtgagaaac tacgtctttt 803761 tggaggatac cagtttgttt caatatacgg aaagcagaca ccgtctcgac aaattccgat 803821 ttgttgattt tgcgcggcgg gggaaatgag agaggcgcct gcctgcggca gcgcgctttt 803881 ttgtttggta tcaaaattga tactatccaa caaaaatgtg cgtactttta ctttttatca 803941 taatggctac aatagagatg agagtaatct aaaggagagg tgttttacat ggcagatcta 804001 aagacacaaa ttctggatgc atacaatttc aggcatgcga ctaaggaatt tgacccgaat 804061 aaaaaagtgt cagacagcga ttttgaattt attttagaaa caggaagact gtctccgagc 804121 tcactcggcc ttgagccttg gaaatttgtc gtcgtccaaa atccggaatt ccgcgagaag 804181 cttcgtgaat acacatgggg cgcgcaaaag cagctgccga ccgcaagcca tttcgtcctg 804241 attcttgcgc gtacagcgaa ggatatcaaa tataatgcgg actacatcaa acgtcattta 804301 aaagaagtaa aacaaatgcc tcaagacgtg tacgaaggct atttaagcaa aacagaagaa 804361 ttccagaaaa acgatttgca tttgcttgaa agtgacagaa cattgtttga ctgggcatca 804421 aaacaaacct atatcgcgct tggcaacatg atgactgccg ctgcgcaaat cggtgttgat 804481 tcctgcccga tcgaaggctt ccagtacgat cacattcacc gtattcttga agaagaaggc 804541 cttctggaaa acggaagctt cgatatttct gtgatggtgg cattcggcta ccgagtgaga 804601 gaccctcgtc cgaaaacaag atctgctgtt gaagatgttg tgaagtgggt ttaaaagaag 804661 aaagctgctc gcatagcgag cagctctttt ttatgcctga ttcgctctat tctgttttct 804721 cctctgatgt aagtacattg ccgttccgag tgcgctgatc agaaatccgg ccaacaggat 804781 cgagtacatg gatgtggctg tgtccggaag caggccgcca gccggaccgt ctgttcctga 804841 tccgcccgaa ccgtttccac cagagccgtt agtcggttga gtgccgggag gcgtatcatt 804901 tcctccgttt ccgtcagttg gctgttttcc gcctggtttg tcggagcctc cgccatgatt 804961 gccgtcatca ccgcctgtcg gttgatctga cgggaatgcc ggcggtttgt tgtttgaacc 805021 ggaatttaag atcgtgtatt cgctgaagtg gtttgtatat cctgtcacca tatcatcatc 805081 gactgatccg tgacctgtct ttgtgaaagc tttctttttt ctatcgacgt gataaatggc 805141 agggttatgg gcttcttcaa tatcaaacat gcgaagcgaa agctgtacgg gctccttgaa 805201 tgattttatt tcttttcctt tttgcttcac tgtaaagtca tatacatctg acagtgacac 805261 atccaattct cccgtagact tgattccgat tgcagtgtct gcggttttaa ggttcgccat 805321 tggcatcttc atgctgtacc agtagttgaa catcgtcaat gaaggatctg actctctttc 805381 tttcaaaagt ttgacctgat cttttttcac tttaagattg ataggcttct cttgagatcc 805441 ttcatgtatt ccataataga caaatggcgt gttggcattt ttagcataaa tcgcaaattt 805501 gtcttcatca agtgtccagc tgccgtcctt ctgctttgtc ggcaggaata cttctttgat 805561 tcgtccttca actttaggag agaccttgtt tcctagtttt ttcagctgtt cggtgaaaat 805621 ctcataatca acgtagccaa ggtcttcacc atgggaggct tctgtaaaga cagaatatcc 805681 gtctcctccg gcaccgacaa aattatttgt tgccacgcgg taggtatcat ccgtatttat 805741 agcaactttg tctccgttag gcgattcaat tttcacttct aacacacggt gtccaggttt 805801 gttgtttaat gtaaaggtat attcgattcc ggccacctga gggaaagcgc cgccgccatt 805861 ttccacattg cttaggcctt gttcaagggc ttctttaatt tgttttccgg ttaaatcggc 805921 cacgtaaagc gtattgccga acggcatcac gttgagcacc tcgccgagtg tgatatcacc 805981 tttgtcaatg cctgctctga tgccgccgcc atttgttatc gctattctgg cgccggctgc 806041 ttctttcgct tttgccagca taccgtccgc gatgaagttt ccgagattcg tttctttcgt 806101 gcgcacatgc tcacgctggc cgtcaagcgc cacatccgtg tagccgactt tttcattttt 806161 cacgtcctct aattcatttt tgaactgatc gagctcttgt tttgcttctg ggttttcttc 806221 tgtatgttca tcaattggca gcacgctcag atttgattta tctgtttgca caacgccttt 806281 ttcatcaaac gcgacatcaa cgcgccccaa gaattggccg tattcttttg cctgcgccac 806341 gatcgtcggt tcttcgttgt tcacgacctc cattttgtct acgagggtgt gagtgtgtcc 806401 gccgatgatc aaatcaatgc cttttacttt tttggctagc tcaagatccc ggttatgtcc 806461 gatgtgggtt aaagcaataa ttttatttac cttttcttct tcttgaatcg ctttgacggt 806521 gttttgtgct gtttcaaagg catcattgaa tacgatgctt ttgcccgggc ttgatgtggt 806581 ggctgtatct tctgttgtca ggccgaatac ggcgactttc tccccgtcaa cgtctaacag 806641 aatgtaaggg tgaatgccgg cctctttctt ttcacctgcc gtaaaggttt gcggcttttt 806701 gacaaatgat ttcagcttgg gctcatttga cacatctacg tttgcactga caatcggaaa 806761 ttccggcgct tcaaagtgat agcggttcgc cggatcaacg gttgcgctgt ttccgcttag 806821 aaaatcagaa agcaccgtcg ggcctttgtc aaattcatgg tttccgaagg tcatggcgtc 806881 atagcccatc atgttcatca ttttcagatc ggccaaaccg ttccatttag taaaatacag 806941 atcgccggaa aacacatctc ccgcatcaag gagaatattg tgatttgttt cgctgcgtac 807001 ttcgttgatt ttcgtcattc gtctcgctgc atcatcgaga tgggcgtgcg tatcattggt 807061 gtgcatgacg gtcagatccc acagtccgtc tttaggagga tctggatttg aatcatcatc 807121 gaattgcagc ttatacacac catagccttc attcgcagac ttgcctacat aagcgacatc 807181 gtctgcttta tcggcaaatg gcttggccaa aagcgaggat tcaaacgtca gattcgtgcc 807241 ggaaacaggc gcgattgacc agttgttgtc tgcttttgga ttgactgttt tttgttcaat 807301 aatgtaatcc atcagcacct gcctattttc aactgcagag ccgtggacaa ttttatcgct 807361 cgtcagatga gggaacccgc cgcctccgga cgcacgatag ttattggtga ctacgagaaa 807421 ttcctggctt gggctgatcg gcttgccttc ataggaaaga ttgatgatac gggatgaatc 807481 cgcattgatc acttttccgt tctcattgta tttagccggt tttgtcacat cgacctgata 807541 tgtgacaccg tcaatcacgt caaaattata ggagcggaaa ttctcgttca gcaaggcctg 807601 gtcgccgcct ttagctggat caatttgatt gaattggcct gctgacatct ccagccagtc 807661 cttgacctcg ctgcctgtca gcttgacgat ttgaacagta ttatcgtaaa gatacaagtc 807721 accgacattt ttaatcgcaa gatctccggc tggaatgttt gtatagtaat tggctccgtt 807781 tctgccgcct gctttaaacg gcgctccagc ggataaaatc ggcaggttct tgtactcggt 807841 atccttcatt tctttttcag cgtaccactt ttgcgcgtca gtcacgatct gaatggaagg 807901 atcatctttg acctgtgcaa agaagctgtt aatatctgct tcggttttgc cgactggctt 807961 tcggacatac tccagtgtgt tttggtgtgt ttgctgaatg gtgtttgtaa cggtttcgtt 808021 tcttgatgtg acgttgccag caatagattc aatacttcct ttggaatctg ctaccttcca 808081 tgagccgtcc gccttttcaa gcttgaggtc aatcacgcct aaatatttgc cccagctgct 808141 tggcatgacg acaggaatgc cgttaattgt tcccttttcc acattgaact gagcaacacc 808201 cgcatactcg gcggaaggaa agagtccgtg ctgatggccc gagataatcg cgtcaatgcc 808261 tttcgttttg gtggcaaggt caaacacggc gttttctgcg cctgatgatt gcgcctgctt 808321 ttcaatgccg gtgtgggcga gggcaataat gacatctgcg ccttccgcct tcattttcgg 808381 gatcgtttca ttggcggatt ctacgatatc ctgcacctga acttgcccct cgagattctt 808441 tttgtcccat gtcatgattt gcggcgggac aaagcctatg tagccgactt ttactttctg 808501 ctcattaccg ttttcatcaa tgagggtttt ttcattaatc acatacggcg tataacggtt 808561 ttcgccgcta gttgttttga cgttggcatt tacaatcggg aaatcggctc ctttgattgt 808621 gccgtcgaga aagtcgagcc cgtagttgaa ttcatgattg ccaagcgttc cggcgtcgta 808681 tttcagcgca ttcatgacgc tgataatcgg atgggttttc gtgccggaga taatgtcgtc 808741 tttttgatat ttcaccgcgt attcacccag cggattccct tgaatcaagt cgccgttatc 808801 cacaagcagg gtgttagggt tttgctcgcg gtgcttttgg atcaattgcg ctgttctcgc 808861 cagaccgaaa tccgccgttt ctttgtcgct gtagtaatcg taatccatca tgttggcatg 808921 aatatcagtc gtagccaaaa tactcagatg cacctgagga gccgcgcttt cttctgcatg 808981 aatgggtggt gttgggagga ttaggctaag tatcataatt gggggcaaaa gaatacggag 809041 aatgttttcg acgtgtgttc gtcttttctg tattctcacc agttctccac ctttcaacga 809101 aatttgtgtt acagctccta ttgtaagaat attttgtaac tatttgtagg tgtttcttta 809161 tgattattgt aaaagggaga aaaatgagta ttatgtagca gtatcaaacg acaaatactg 809221 ggcatttatg cttatcgttt gtcacaatcg cggaatgttt attttagtgt ggctggggta 809281 gagtgtttta tgtagacata taaagcggga ggttatgaat catggggaaa aaaattgcag 809341 ttgttttaac atattatttt gaggacagcg agtacactga gcctgcgaaa gcctttaaag 809401 aagcgggaca tgaactgact gtcatcgaaa aagaaaaagg aaaaacagta aaaggcaagc 809461 agggaacagc ggaagtgacg gttgacgcgt ccattgacga cgtaaattct tcagactttg 809521 atgcgctttt gattcctgga ggattttcac cagaccagct tcgcgctgac gatcgtttcg 809581 tccaatttac aaaagcgttt atgactgaca aaaagccggt atttgccatt tgccacggcc 809641 cgcagctttt aatcaatgcg aaagcgctcg acggccgaaa agcgacgggc tatacgtcca 809701 ttcgtgttga catggaaaac gccggtgccg acgttgtgga caaggaagtg gttgtttgcc 809761 aggatcaatt ggtcactagc cgcacaccgg acgatatacc ggcatttaac cgcgagtcat 809821 tggcattgct tgagaaataa gaaaaaacgg acgctcttgg gcgtccgttt ttttgttgct 809881 taggcttgag cacctgtcag tttcttgtac ctgtaataca agaaagcagc tgcagccgtt 809941 ccgatgaccg caatgccgaa gtcgaatatg aaaatatggg cgatgccccc cgcttttgcg 810001 ataagccctg ttgcaatcgg cagcagaatc gatgcaagac ttgaagcagt cgctacaatt 810061 ccggtaacgg ttccttttcg cttccagaaa agctctgtca ttaacgtaat ggtaatttga 810121 aacacacccg cagttgaaaa gcctaagaaa aaggcagtga tgtccagcac aactgggata 810181 tgaacggtca gcatgactgc gagcgtacat aaagtaataa taggatataa gagcgttatg 810241 aagacaggtt tgacccatct attcagcaaa acggctaata ataaaacaga tgccagagat 810301 cctatactat aatagctcag caattgtaca gatgctgatt cagctaaacc ggctgccttt 810361 tgcgcgtagc tcgggagcca gatttgagaa accgtaaata aagccgtgga tgtaaaaccg 810421 atgataatca gtgcggtgcc ttccttctga aaaacgggtt cagacaagaa aacgggagat 810481 tcctgttggc cgctattagt tggtttctta tgttttttag gaaacgaaag cgttgataaa 810541 taaataatat tcaggagata gaccgctgcc ggcagataaa aagcaaatcc gtaaaacatg 810601 ctgtggtctg ctaaaaatgt gatcaaaagc ggcaaaagtg cggcccccac agacataaag 810661 gctttaacca agacatttgc cgaaccggaa gcagacggaa agagctcggt tagggccgga 810721 tatgttccgg catccatggc tgaattagcg actccggcta ataaagcgaa cacaaacgcc 810781 agctcatagc tcggtgataa aggaataccg actaaaaaga cggccataat tcccgcagaa 810841 gcgacaacaa gcggctttct gccgatttta tctgatagaa cgccggaaat gccgtatgtc 810901 agcagtttgc caaacccgat agcggcaatg acataactga tgccggtcgg atcggtattc 810961 cactgttttg ttaatgaaga catattggat gcgagaatga tgttgaccat ccccagaaag 811021 aagtagttga tatacattcc ggatgctgtt ttgatagatg tcgtttgcat gcttgtactc 811081 cttcaaatct tattcgaaca ctttgctgtt ttggtttggg gaaatgataa aaaagactcg 811141 ccgagtttcc ggccagtctc cattatttac gaagcgaggc taattcttga gcaatcgcct 811201 gcatttcact tgggctgaat gattcttttt tcatcaccat tctgtgaagg tacgtgaggt 811261 cttcaatctt ctcatcactg aaatcctccg ctttgattac gccgacgttc agcatgttca 811321 gcttttggga aatctcttca atcatttgag ttaatgtttc tgtatttggg ctggacaaag 811381 ggttccatcc tttctatgcg caatataggt atgttttatt ctaacagaat tccatcagaa 811441 aaaaacccta ttctaaaagc aggctgttca ttccaaaaaa gtgaagacat cagttgaaaa 811501 gaaaatgaac atcctactaa gatattcatg aaggtttctt tttagagaaa taggggcaaa 811561 gaatagggag gttgcacatc atgataagcg tgttatttgt ttgtttaggt aacatttgcc 811621 ggtctccgat ggcggaagcg atttttaggg acctggcagc caaaaaagga ttagagggga 811681 aaatcaaggc ggactcagcc ggtattggcg gctggcacat cggcaacccc ccgcatgagg 811741 gaacgcagga gatattgcgc agagaaggaa tcagctttga tggcatgctg gcgcgtcaag 811801 tcagcgaaca ggatctggac gattttgatt acatcattgc aatggatgca gaaaatatcg 811861 gaagtctcag aagcatggcg ggttttaaaa acacctcgca tatcaaaagg ctcttggact 811921 atgttgaaga ttcagatctg gctgacgtac ccgatcctta ctacacaggg aactttgaag 811981 aggtctgcca attaatcaaa acgggctgtg agcagttgct tgcatccatt caaaaagaaa 812041 aacaattgtg agtgaaagga gaatttgcat gaacaacgaa cgtttaatgc tgaaagggat 812101 atttctcgga gctgcggcag gcgcggcgtt atcactgctc cataagccga caagacaggc 812161 gtgcgggatg agatggctga catgcaagca taaactttca ctgtacaaaa gcaacccaga 812221 gctgttaaaa aacactgtca tcacaaaagt ggatgaggcc aaaaagctcg cccgaacgct 812281 ttcaaaggaa gtcgactttg tgaaccagca ggtgaaagag ctgaagaaaa caacgccgca 812341 agtgatggaa ctcgtgcaag aaacgaaaga gcatttttca aaaaaatgat caaacatgcg 812401 aggtgagacg acatgagttt tttgaaagag cttttcagca gatacaccct tcatgaagga 812461 caaagtaaat cagcggagct ggcgtatttt tttctattgt cactgtttcc gtttttgatt 812521 tttatgctga cgctcaccgc gtatcttccg ctttctaccg atgatgtttt aggagtcata 812581 gaacaatatg ctcccgccag tgcgatgtca ctcgttgaat ccattaccca tcaaacctta 812641 aataatcgaa atggcggttt gctgtcattc gggattatcg ccgcattatg gtctgcgtct 812701 aatggaatga atgcgatcgt ccggtcgctg aaccacgcgt atgatgtgga agaaaaccgc 812761 tcttttatca ttgttcgtct aacctcgatt tttttgacga ttgccatggt atttacgatt 812821 ttagtggctt tgcttctgcc ggtatttggc cgggagattg gaaggctcgc ttctgacttt 812881 gtcggcgcgt cggatctgtt tttatccgtc tgggccgcca ttcgctgggg tgtcagcccg 812941 cttgtgcttt tgattgtttt ttccgcgctg tatgtgattg cgccgaacaa aaagctgtct 813001 ctccggtttg tcatgccggg tgcggtcttt gcgactatcg gctggatcat tgtcagcaca 813061 ttgttttcat tttacgtcag cacgtttgcg aactatagcg ccacttacgg gagcatcggg 813121 ggaatcatcg ttctgatgat ttggttttac ttgagcggca ttttaattat cctaggcgga 813181 gaaatcaacg ctcttttaca taaacgtaaa aagcttcctg atgaaaatcc ctaccattag 813241 cgcaccctat aaacgaactt cggttcaaaa agaagtcggg gggatatcgt gatgaccaag 813301 catacgaaaa aaggcggaag ccataacaaa caaaactcga aaagcaaatc gagccataaa 813361 acaagcggaa gcgccaacgg acaaaacggc taccattagc ataaaagcct cctgacatga 813421 tgtcgggagg ctttttgatt aagaagatga agaataggtt tcagccggtg accagctttt 813481 cggtttgccc agcacaaggg ccagccacac agagctaagc gtgagagtaa tgaagtagaa 813541 caagtttgcg ctttcaaatg tctgcatata ccagccgccg gcaactgggc cgaggatgct 813601 accgagactg aatgtaatgc cgcaaagcag gtttcccgcc ggcaggaggt gaggcggaag 813661 aaggtctgtc atatagctga tgccaagtgt aaaggttgat ccgactgcca ttcctgcaat 813721 aaaaaagcag ccgccgatca cgtagggcga aggaaataca ccggcgatga aaaagcaaag 813781 agccccagtc agtaaaatca ccagcagcac attccgcctg ccgtatttat cgctgaggat 813841 gccgagcgga aactgaaaga taatgcttcc aatcgcaaat gcgggaagga tgatcgctac 813901 tgcgtctact gatatcccca aacggagcgc gtacaccgga aagcttccgt tcagcgccgt 813961 ttccagaaag ccatagccaa atgtaggcat aaaggcaacc cacccaaaca gcatggcctg 814021 ataaaatcgc ctgaaactat tgtctgattt ggtttcatga ggactggttt ccgggtatgc 814081 attttgtaga aagaaaacaa aaagccacgc aaacagactg atgcagccgg acacgataaa 814141 aggaagcgac ggactcagct tgacaagcgg caccatgaac gggcctgcgg caaagccaag 814201 gccaaaggaa agcccataaa tagacaggtt tcttccgcga ttttgttttg atgacatgga 814261 ggtcacccac gtttgcgtag aaaagtgaag catgtggtcg ccgattccaa tgaacaggcg 814321 aagcaggaac cagacccaaa ctgactgaag ccaaataaat ccgaataagc ttaaaatgac 814381 aatgcttccg cccatgacga tcagcggctt gaacccgagc tttctgagcg gtgcttccat 814441 aaacggcgaa gccaaaagca caccgatata cagcccggtc gcgtgcaggc cgttgatagc 814501 agcggattct ccatttgttt caaaaatgat tgaaatgaca ggcagcagca tgccttgtga 814561 aaacccggaa atggaaacga gcaagacaag gataaagaaa tgaaatcgtg acatcgtgtc 814621 agttctcctt atatggaatc tatgttgatc gtacaacgtt ttccaaaagc aggcaacctg 814681 aaaaaagcct atatcacgct atacatttgc cctcgtgtaa tcatgaaggt ttttgtgaag 814741 aataaaaata aaacaagtca taaaaaagga gctatttcac catgaatcgt atctttttta 814801 ttttagtggc ggccggtgtt ccgctttctg tgattggcag tttgatgcat tggccttccg 814861 cggttctatt tgcagtttat tgcgtgacga ttatcgcgct tgcaagctat atggggaggg 814921 cgacagaatc actgtccatc attgcaggac cgcgtatcgg cggtttgttg aatgcaacct 814981 tcgggaatgc ggtggagctg attatttccc tttttgcatt aaaagaaggc ctgacaggaa 815041 tcgtgcttgc ctctttaacc ggttcagtgc tggggaacct gttgctggta gcgggcctat 815101 cgttttttgt cggcggttta aaatataagc ggcaggaatt taatatccat gatgcccgcc 815161 ataactccgg gcttctgatt tttgccatca ttgtcgcctt tgtgattccg gaggtattct 815221 ctgttggtat gggaaacgcc agcaagctca atttaagcat cggcatcagc atcattatga 815281 ttctgttata tgtggcggcg ctgtacttta aacttgtcac gcatcggggc gtttatcagc 815341 cgaataatgc cgctcagact gaagaagagg aagagccaga atggtcaggg aaggttgcga 815401 cgattgtctt gtttgcggca acgattgtgg ttgcatacat atccgaaaac ctggtccata 815461 cctttcactc ggtggctgaa cagttcgggt ggagcgagct gtttattggg gtcatcatcg 815521 tggcgattgt aggaaatgcg gcggagcatg cgtcagcgat tattatggcc ttcaaaaata 815581 aaatggacat tgctgttgaa attgcagtag gctctacgct gcagatcgct atgtttgtcg 815641 caccggttct cgtcatctgt tctatctttt ttccgacaag catgccgctt gtatttacat 815701 tgcctgagct cgtcgcgatg gtatcagcgg ttctcttgat gatcgcgatt tcgaatgacg 815761 gggattccaa ctggtttgaa ggggcgacac tgcttgctgc atatgtcatt atggcgatcg 815821 gctttttcct tctttaacct gaaaaaatga tggataacaa caaagcggga tgaaaagact 815881 aagggaaaat gccatagaaa gagtgatatg atgaaaaagc tatttcattc cacacttatt 815941 gtgttgttat tctttagttt tttcggcgtt cagcccatcc acgcgaaaaa gcagtttaag 816001 gttcctaatt ctgtcgcaag catttcaaag gaaaacacgt atccgaatgc ttcacaggat 816061 cagccaatgc ttcagccgag caagctggca aaggaattgc tcgatcattc tgaggtaaag 816121 attgaaaatc cgcatctcat caaaatgctg aatgaatcca acatatccgg cacaccgctt 816181 gcagtagggt accgggcgac aatatttctc gggaaatggg cgctcggcta tgaatcaaat 816241 gaaacagtcg caaactggga atataaaaaa atcaatacaa accgtgcgga taaccgcggc 816301 gggaaagaaa cggctgaaat gcattatgcc caggaacagc agtacagagt gaagggcggc 816361 ttgacagcta aagttccaaa tgctgaagat gtcaaaagca tgatgatgca aaaagcaatg 816421 aagaaaacga acctcccgct tgcatttgag acggtcatcg gggctggcac aaaacgggat 816481 cagatttata aagtcgctcc taaaaaaatc ggttatctac atgcatatgc accggctgtg 816541 aatgaaaaag gaaaagtgac ttacggagaa gtgtacttag tgctgaaagg aaataaacga 816601 aaactcgtcg tgaaaaatgt cacgtcacag ggaatcggcg cgtggattcc ggttcaagat 816661 catgtcacgt ttggctttca gctttcctca ctgccaagat aaataaaaaa ctgattccaa 816721 ctcggaatca gtttttttgt ttattgggtt ctctcgattc ggaccgcttc ctcaagcatt 816781 tgcacattgt tttggtagag ctggcgaacg agaacccgtc ttactgcaag gctggcactg 816841 aaataatcat catctttcac catgccttta accgtaaatt cgacgccgcg attgatttta 816901 ttcaatgcgg tgatgccgtg gatttgaaac ggttctgtcg gattgccgaa ttcatcccgc 816961 ttcaatgaat cacgaagctc ttcattcagc atgtcacatg cctcttccaa cacgctgtac 817021 acgcggtccg gatcttcttt aaagctgata agaaaggatt cggtaatccg cataaaatca 817081 atattatagt tctctatttg tctgacctcg ccgttgctga tggtgagcag cttcccgctc 817141 cattcccgga tttgcagcga gcggaggccg atttcctcca ctgtcccgtt gaacaagttg 817201 ttgacggtga cataatcgcc tttgtgcagc tggcgttcat atattaagaa tacaccagcc 817261 agcacatctt tgatcagcga ttgggcgcca aaaccgatca cgatacctgc tacgcccgcc 817321 ccggccaata tcttgccgaa atcatgcaca aataaagaaa taacgtaaaa gataaaacca 817381 attgttgccg tatactgggt gacagaacgg acaaggcttt caatcgtttt ttcctttttt 817441 tcttcaataa agtccgtccg tttaaaaaat agctgtacca gccggttgat gataaagaca 817501 ccgatccaaa ggataacggc aacgaggaga atatcgacga ttttattttg aaaaatctcc 817561 gtaagtgttt ctttcatccg catctaactc ctggcttgac gttttgtgaa gtctgtatcc 817621 tgataataac tgtttttgac aagaacattc ggtccgaggc accggacatt cgggcagtgg 817681 caactcagtt ctttcgcaag cttggtctct ctccactttt cataggcgga agggaggctg 817741 tccgtctgaa tgttgccaag cggcggggta tcaccgaaat cggtcacgat aatgtttccg 817801 tcgaaaatgt tcacattcag gcgggatcgg ccgtcagggt catttcgcac tgtgacgttt 817861 ttcgccgcgc gaagccggcg aagcagcttt tggtcgtctt cgtccggact gcaggcataa 817921 aacggcagcg ttccgaacag catccacgta ttttcatcac gaatatccag caagcggtga 817981 atggcctgtc tcatctcttt caggctgagg gattcaagag cgcttgcgaa atcgcttgga 818041 tacattgggt ggacctcgtg acgctgacat ttcatatctt ctgtgatttg gcggtgaata 818101 tgctcaatat gcggaagtgt tcgtttgttc agcatcgttt ccgcagatac cattactccg 818161 gcatccacga gcgtgcggct gttttcgatc attttttcaa aatagcgcgc gcgctgttcg 818221 aaggtcggtt ttctgtccat catggcaaag ccgatttcag caaaatcttc aactgttccc 818281 cagttatgtg aaatatgtag cacatcgaga tacggaatga tccattcgta ccgctcgatg 818341 tcgagggtca gatttgaatt aatttgtgtc cgcacacccc gttcatgggc atatttcaat 818401 aaaggaacaa catattcttt tactgatttc aacgaaagca tcggctctcc gcctgtgatg 818461 ctgatggatc tgaggcgcgg gatttcctcc agccgtttta acagaagatc tattggcaga 818521 gcattcgggt ctttaggctg caatgtatag cctacagcac aatgctcgca tctcatattg 818581 cacagtgtcg ttgttgtgaa ttcaacgttt gtcagctgca tgtctccgta ttggtcaaca 818641 tccatatagg cttcccaagg gtcaaactcg ggcgtaatcg gacgcagctt cgtgttttgt 818701 gtcatgacta tctaactcct ttataaatgg gcatactaac gctgccaaca gttaatttta 818761 gacctgattt gccaagatcg caagtagcgc ggcgattgaa aaacggcaaa aaatgagcta 818821 ccataataaa aaatgaatgg aggaacagaa tggggaacgc cgtaaacaat aaagatcagc 818881 agattgatta tttaaagaac agacttgaca tgtttatgaa cgtcatcgat tcattagacc 818941 ctgaagcaac cgacgttgaa gatatagaca ggcttatcag catgcttgat gacctggaag 819001 ccaaatacga acgttttaaa aaagattggg aataaaaccg cgtgcccgcc gcggtttttt 819061 tattggcata aagcaacagt ataaaacaaa gtctctatct gtaaaataag aaaaaatgca 819121 gaaggagcgc tggccatgaa gtggatgtgt tcaatatgct gcgccgccgt attgcttgcc 819181 ggaggtgcag cacaggcgga agcggtgccg aatgagccga ttaattgggg ctttaaacga 819241 agtgtcaatc atcagccgcc agatgccggg aagcagctga acagtttaat tgaaaaatat 819301 gacgcgtttt atttagggaa tacaaaggaa aaaacgattt acttaacgtt tgataacgga 819361 tatgaaaatg gctatacgcc aaaagtgctt gatgtcttaa aaaaacatcg cgtaacagga 819421 acgttttttg tcaccgggca tttcgtaaag gaccagcctc agctgatcaa acgaatgtca 819481 gatgagggcc atattatcgg caatcattcc tttcaccatc cggatttaac gacaaaaaca 819541 gctgatcaga ttcaggatga acttgattca gtcaacgaag aggtttataa aattacggga 819601 aagcaggaca acctgtattt gcgtccgccg cgcggcgtgt tcagtgagta cgtactgaaa 819661 gaaacgaaac gcctcggcta tcaaaccgtt ttctggtcgg tcgcttttgt tgattggaaa 819721 atcaacaacc aaaagggaaa gaaatatgcc tacgatcata tgatcaagca ggcgcacccg 819781 ggagccattt acctgcttca caccgtatcg agggacaatg cagaagcgct ggatgacgcg 819841 attacagatc tgaaaaaaca gggctacact tttaaaagca ttgatgatct gatgtttgag 819901 aaagaaatga ggctgccgtc tttgtaaaag agaaagacct ctccttaaac ggagaggctt 819961 ttctttattt tatacattta atcagtgcgg cccagtccag atccccgaag cctttctcaa 820021 tcccgctttc aaaatggctc ttggccagct cggcaagagg aagatttgca gaaacccgtt 820081 ttgcggcggc gagtgccagg ttggtatcct tcagccctaa agacattttg aagccggccg 820141 gctcaaattt ctgctcggcc ataatggttc cgtaattttg atagactgga gaaccaaaga 820201 gcgcgctggc gatttctaaa aattgttttt gttctaagcc gtatttctcc atcattaaaa 820261 aggattcaga taacgcctcc agcatggaca caagcaagaa attaatgctg attttggctg 820321 catttgccgt cttgctttct tcgccgacgt caaatatctg ctggctcagg ctgtcgagca 820381 gaggcttggc agcttgcttt gcttccgccg gtccggctgt tatgatacgg agcgcggctt 820441 tggctgcggc atccggtctg ccaaggacag gagcggcgag aaaaaattgt cctttctctg 820501 catgagccgc tgcgagcttt tctgagaact caacactgat tgtgctcatc gagatgtgta 820561 tgccgttctc tgctaatcct tcaagcagcc cgtcttctcc gaatgtcacg gtgctgacag 820621 aatcatcatc tgcaagcatt gtgatgacaa tatcagcgga ctttgccgcc agccgcggcg 820681 tatcagctgc ctgtgcgcct tctgtgacaa ggtcttctgt cttttgtttc gtccggttat 820741 agacagtcaa ttcgtagcct gcttgaagaa catttcgggc aatgggctgt cccatattgc 820801 cgagtccgat gacagcaatt ttcaatctaa tcactccctg aatatttttt ccattataaa 820861 caatatgaac agaatatgca tagcgatcgg cttacaacaa aaaagaacag ctgctcgctg 820921 tcctcattta aaaatattga accatccttt atgtacaaac caaatcagca ttccaatcac 820981 aagcgcggcc atcaggccaa gtacagcgaa atatccgtat ttccaatgca gctccggcat 821041 aaagtcgaag ttcataccgt atacaccggc aataaaggtg agcgggatga aaatggttga 821101 tacgatcgtc agtgtcatca taatcgcatt catccggttt gagtttagcg tcacgtagct 821161 gtcacgcaag tcggacgtca tgtcacggtt ggattccaca atttcagaca actttaacaa 821221 atgatcatat atgtcgctga aataggcttt cgtttcccgc tgctctttca catggtcaag 821281 gcttaaaatc cggtagagca aatcacgcat cgggataatc gtccgtctca aatgcaatag 821341 gtctgttctg agatcaaaca cctcgttcat cagcgttcca tacgttttgt ggggacggct 821401 ttcttcaatt tcattcagcc ggtcttcaat tttatacacg agaggaaaat attcatcaac 821461 aagctgatcc atgatcatat aagaaatatg cccgggccct tttttcaata tgtccggtga 821521 agcatacaaa cgctcccgga ctttagcgat accgggcgtt tcgtgtaaat gaaaggtgac 821581 gacaaatttt tcgccttgaa agatatcgac ttcctccgtc tcaagtgttt ccttattcag 821641 cgcatgaatc acgtaaaaac gatagccgtc ataatggtca agctttggcc gctgcatatg 821701 ctggaagcaa tcctcaatgg caagcgggtg aaaatgaaaa aaatctctca ataacgccgt 821761 ttccgtatcc tccgggccgt aaaaatcaac ccagtaccat gcaatatcag gctgttccac 821821 tcgttcgatc ggtatatttt tcagcagctg atgctctgtt gtgattgcgg taatgttgat 821881 cataaacaac cctccacctg ccattatatc atgcggtctt tatgagaaaa gtatacggta 821941 ctctctgcct aattccagcg gcatgttata ctgaacaaaa acggaaaaaa gggtggatct 822001 catgtggaag gaaaaagtat ctgtcacgcc tccgtatcat tttgaccgcg tgctggacag 822061 gctgtcttta gaccccctca atgctgttga tcgagaggcg agggaagtcc gtgtgccaat 822121 cagaaatcaa gcgggggacg tatgtattgt aaaggtacag gcgttaggcc atgcgggcga 822181 gcctgagttc ctcgtcagcg gggaaacgga tcagggagaa atgatgaagg aaatcaagcg 822241 gatttttcaa tgggaaaatc atttgcagca cgttctggat catttttcaa aaacgagcct 822301 gtccgccatt tttgaagagc atgccgggac gccgcttgtt ctggactaca gcgtgtacaa 822361 ctgcatgatg aaatgcatta tccaccagca gcttaatctt tccttcgctt acacgctaac 822421 agaacggttt gttcatgcgt ttggcgagca gaaggatggc gtgtggtgct atccaaagcc 822481 ggaaacgatt gcggaactcg attatcagga tctgcgtgat ctgcaattca gcatgagaaa 822541 agcggaatac accattgata catcaaggat gatcgcagaa ggcacactca gcttgtcaga 822601 gctgccgcat atggcggatg aagacattat gaagaaactg atcaaaatca ggggtatcgg 822661 cccgtggacc gtgcaaaacg tcctcatgtt cggacttggc cgtcccaatt tattcccgct 822721 tgccgatatc ggcctccaga atgccatcaa acgccacttt cagctggacg ataagccggc 822781 aaaggatgtc atgctggcga tgagcaagga gtgggagcct tatttaagct atgcgtcttt 822841 gtatttgtgg aggagtatag aataattcgt ctgacaatga aggaaatcct gcaaacgtgt 822901 tatactagaa agatgtgaaa aaaccatttc actttctgcc atccgcagaa agcttcatat 822961 agaaacggag agaacaacgt gaaccaacaa aagaaacagg cgcccgtcga actgaaggtc 823021 ggacaaactt ttccgctgac gattaagcgt ctcggcatta acggagaagg tgttggctat 823081 tttaagaaaa aagtcgtctt cgtgcccggc gcgcttcctg gcgaagaagt tgttgtgcag 823141 gccacaaagg tccagccgaa gttttcggag ggccgcatta agaaaatccg caaggcatct 823201 gagcaccggg tggcaccgcc ttgccctgtt tatgaacaat gcggcggctg tcagcttcag 823261 caccttgcat acagccagca gcttcgggaa aaacgtgata tcgtcattca gtctcttgaa 823321 cgccatacga agtttaaagt tgaaaacatg gaaatcaaag aaacgattgg catggacaac 823381 ccgtggaatt accgcaataa aagccaattc cagatcgggc gctcgcaaag cggcagcatc 823441 atcgccggct tatacggcct tgattctcat gatatcgtgc cgattaaaga ctgtatcgtt 823501 cagcatccgg caacgaacaa aacaacaggc atcgtccgcc gcattttaga ggacttcaat 823561 gtgtctgttt ataatgaaag aaaacgaaaa ggcgacgttc gcacgatcgt gacgagagtc 823621 ggctttgaaa caggcgaagt gcaggtcgtg cttgtaaccg caaaagaaac gcttccgcac 823681 aaggaagaaa tcgtcaaagc gattcaaaag cgattgccag aggtcaaatc cattattcag 823741 aatgtaaacg gggcgaaaac ctcagtgatt tttggtgaga aaacaaaaca gctcgccgga 823801 aaaacagtga ttcaagaagt gctcggcgac gtatcttttg aattgagcgc ccgcgctttc 823861 ttccagctca atccggaaca gaccgtcaag ctgtatgatg aagtgaaaaa agcggcgcag 823921 ctgaccggaa aagaaaaagt cgttgatgcg tattgcggcg tcggcactat cggcatgtgg 823981 gttgcggacg gagcgaagga agtccgcggc atggacgtca tcaaggaatc aattgacgat 824041 gctaagaaaa acgccaaaaa acacggcatg gcaaatgcca catacgtaac aggaacagcc 824101 gagcactggc tcccgaaatg gacgaaagaa ggcttccgcc cggacgtcgt cattgtagac 824161 ccgccaagaa cgggctgtga cagcacgttc ttggacacga tcaaaaaagt caaaccgaaa 824221 cgctttgtct acgtttcctg caatccatcc acgcttgcga aagatttgca gacgctgtcg 824281 aaggactatc gcgtggacta tattcagcct gtcgatatgt ttccgcagac ggcgcatgtt 824341 gaagcagtgg cgaggcttgt attaaaatcg tctaactaaa aagaacattt cccagtcata 824401 aaatagtttt cctaataaga cctggatttc ggtaaaataa acaattccga tttccgggtc 824461 tttttcgtgc gcagctcttg tcctaacggt ctgttctcaa ttttatcttc cttcttttcg 824521 cggagatctt tattttaact ggcgaaaaga attgaaaaaa cgtgttgaaa agcaggtgaa 824581 aaaaagcgtt atttaaccgg aaaaatatcc tcccagtatg tttaaaatac atgagtagaa 824641 tgatgtaaaa tcatagatgt attttcataa tttgtaaaat tatatattga cttgcagtta 824701 ttacgtgtga aatattgatg ataggaatat aaggaaagta tggcgtatat catttcaaga 824761 gtcattcgat gtaaaaagtt gaaacattgt aataaatgaa agaggtgaaa atgatggcca 824821 accccatttt aaaatgcata acgtatgagc actacaacaa ttaaataata gtgccgagac 824881 gataacaact attacagtaa tacctacaat ggttatatcc ttgcgacaat catgcttcat 824941 aatataatga ttttagattg acacttggct aaaaagtatt gcagagaagg aaatggataa 825001 ttaaatggat aaagtatata aaagaagttg gtttcaaaca tttttggcat ttttagtatc 825061 tcagctttat tttaattttg tagaattaac gggatggggt cctaagtata gagaaatgaa 825121 tggattccca gcaaacatag ttgaactaga tttctttcaa acatatcttt cattctatga 825181 taatccatgg tttaatatta ttactgtttt cttgggagtt ttcactatta tacaaataat 825241 tacagggata acaaaggata ttcgaaatta aagcaataac ttctgatgcc ttatttaatg 825301 atgaaagaaa atgtacactt tcttaattat cttatgagtg aagactgcga cacttagtca 825361 gcagtctatt ttatggttct ggatcaggat taccgaatta taaccctata caaatatata 825421 gtaggttgcc acttgctgcg ttggttattt tctaaatcat gagcaaatcc caaatgattc 825481 agattgaagt tcttgaattc ttttaaataa gggtttattt tctcttctca tcctctttac 825541 tccatgtgat tcacaagtgg tagcagctta agtaggtttt ttcattctct tgagtactca 825601 gttataccac ccccaactca atttgcttta tctctattag tttttccgca aatatgatat 825661 agagatacgg atatggtgta gtgttaaata tcttatcttc aataacaggg caattatttt 825721 gcgttggtaa tatggagaac tcatatgata ttctatttag gttggaatcc tttttatcca 825781 aaaagttcaa aagcaaggcc actaagaaag acgaaggtca gcgccagtta accagaatat 825841 aaaaaatagg gtagataatc atcccacgtg aaatcttcaa aatttactat agattgataa 825901 gaaatgcttt cgcatgcgat aagtgtaaaa gaagcatggt cagtttttaa tttgggataa 825961 aggttcagcc gtatcccata atgaaaggat ttgatttttg ttatgacaga aaatttctgg 826021 cgtgaattac cacggccgtt ttttgtactg gcaccaatgg aagatgtgac agatgttgtt 826081 ttccggcatg tagtaagtga agcaggcaga ccggatgtgt tttttacaga gttcacaaac 826141 tcagagagct attgccaccc ggatgggaag gatagcgtgc gcggccgttt gacttttaca 826201 gaggatgaac agccaattgt ggcccatata tggggagata agcctgaaaa cttccgtaaa 826261 atgagtattg gcatggcaga gttaggattt aaaggactag atatcaatat gggctgccct 826321 gtgcctaatg tggcggggaa tggaaaggga agcggcctta tttgccgtcc tgcagttgcg 826381 gcagaattaa tacaagctgc aaaagcaggg ggattgcctg taagcgtgaa gacaagactt 826441 ggatacacgg atgtggatga atggcgcgag tggctgacac acattttgaa acaggatatt 826501 gcgaatcttt ctattcatct gcgtacaagg gcagaaatga gcaaagtaga tgcgcattgg 826561 gagctcatcc cagagattaa gaaacttcgt gacgaggtgg caccagatac attgctaaca 826621 ataaacgggg atattcctga ccgtcaaact ggcttgaaac ttgctgaaca atacggcgtc 826681 gatggaatta tgatagggcg cggtattttt acaaatcctt tcgcttttga aaaggagccg 826741 aaagagcata gcagcaagga attgcttgat ctcttaaggc tgcatctgga tctccatgat 826801 gaatattcaa aagaagaagc ccgtccatac aagcctcttc ctcgcttttt caagatttat 826861 ctccgcggat tccgaggggc aagtgaatta agaaatcaat gcatgaacac aaagtcaaca 826921 gatgaagtgc gtgcattgct cgacgacttt gagagaaagt atcttgatgg gatagagtaa 826981 cagcagtgct tgattcaaaa aaggctaaca aaataaaggg atttttacac aattcttgac 827041 taaaataaac ctggattttc ggtaaatccg ggtctttttt gtacgcagct tttactcagc 827101 ctgtcttttc tctaatttat tgtaagaaaa taatggtata tttagtggag atatcatata 827161 aagggggaga ggaaaatgaa acggctatgc atcatcccct gcggcaagaa aaaaatctgg 827221 gatgtccagc ctgatgccgg gccggtaaga gcagaggacg cttatctcag cccgtttcat 827281 caggcgtgcg agcggtatgc aaaaacattt ttcgatgagt gggtgatttt gtcggcgaag 827341 cacgggttcc tccgccctga tgatctcgtt tcgggaaatt acgatgtcac ttttggcacc 827401 ggtcatccgg aaatcatgac agcggacgag ctgcgccgtc aatttcacga aaaaggcttt 827461 tctgatatcg aagagctagt catgcttggc ggaaaaaaat atcgaagcgt tctaaacgcc 827521 gtcatcggag aacaccagca tatcagctgg ccgctatcat catacaaagg cataggctat 827581 atgctccaag cgctgaaccg ggctgttgaa gaaaagcatg aactgtagca cgtacatatg 827641 aggaaaagag tgggaacatg aaaaaacttg tgtttggctt gcttgccatt gtgttattcg 827701 gatgcggact atatatctat catgtatggt tcggtgatcc attttcgaaa aatgctgcag 827761 aacagaagct agtgtcttat gtgaaacaaa cctatcctaa gaaagaaatc aagatcacga 827821 atggggtata taacgctaaa acgtctgaat atgtatttga agcaacctcc caatctcatc 827881 gctacccaat gtgtacgaag ggatttctgc atcctaaagt aacgtgcgat ggaattgaag 827941 aagcgtatac cgaatcagta gcaaaacatg taaatgaaga agcaacgaag gcaatcgaag 828001 cagatctgaa aaaagcggtt cctcgattta taaaagctga tgctgctttg agtatcgaaa 828061 acggacagtt cacgttagat acaaaatgga acaaaaagct ggctgaaaaa gcgcctatga 828121 gcatgacgat tcagttagac gccagcgggt tatcaaaaac agatgccgca aagatggcgg 828181 aaacggtcag aaaaacgctt aatgaaaagg gatatacata ctcaaacggc acgatagact 828241 gtatgcagaa ggacggggac ggcggtattg gatatgtcaa atattcaatt gattttcttt 828301 caaaagcagc tattcagtca aacgatgcag aggaactagg aagttaaaaa gatttccaag 828361 gaaataaata cgtcgatcat tgtcaaaggc cgggtgatat ccggtctttt ttttgcatgc 828421 tgtaaaacga gacaaatgaa tcagtttgag acaaaacgag acacacgtct caaactgtct 828481 ccaaagtgaa gatgagaaga ctgattttac gggctcaaaa gactggcaca cttcttgcat 828541 ttataatggt gaaccctaaa tagaaggagg cgcacaaaat gaaattgtta aaacgagaag 828601 gcttgtcatt aactgaggaa aaagcgctgt ggatgtacca aaagatgctg gagatcaggg 828661 gctttgaaga caaagtgcat gaactgttcg cccagggagt gcttcccgga ttcgttcatt 828721 tatatgccgg tgaggaagcc gtggctgtag gggtgtgcgc tcatttacat gatggcgaca 828781 gcattacaag cacccacagg ggacatggac attgtatcgc caaaggctgt gacctggacg 828841 gcatgatggc ggaaattttc gggaaagcga ccggattgtg caaaggcaag ggcggttcta 828901 tgcacattgc ggatcttgat aaaggcatgt taggcgcaaa tggaatcgtc gggggcggct 828961 ttacgctcgc atgcggatca gcgctcacgg ctaaatataa acagactaaa aatgtaagcg 829021 tttgcttttt cggggacggg gcaaataacc aaggtacctt ccacgaaggg ctgaatttag 829081 cggctgtatg gaaccttcct gtcgtatttg ttgctgaaaa caacggctat ggcgaagcta 829141 ccccatttga gtacgcatca gcctgtgatt caatcgccga tcgggcggct gcttataaca 829201 tgccgggggt tacagttgac ggcaaagata ttttagcagt ttaccaggca gccgaggaag 829261 cgatagaaag agcaagaaac ggcggcggcc cgtctttgat tgaatgtatg acctacagaa 829321 actacggcca tttcgaagga gatgcccaaa cctataaaac gaaggatgaa agagttgagc 829381 accttgaaga aaaagatgcc attcaaggtt ttaaaaacta ccttttaaaa gaaacagatg 829441 ctaataagct gtcagacatt gaacagcgtg tcagcgaatc gattgaaaaa gccgtctcgt 829501 tcagcgaaga cagcccatat ccaaaagatt cggagctgct gacagatgtg tatgtgtcat 829561 atgaaaaagg aggaatgtaa gagatggcga gagtcataag catgtcagac gcgatcaatg 829621 aagcaatgaa gcttgcgatg agaaaagacg aaaatgtgct tttgatcggt gaggatgtcg 829681 ccgggggagc ggcggtcgat catttgcagg atgatgaagc atggggcggt gtattagggg 829741 tcacaaaggg actcgtacag gaattcgggc gtacaagagt gctggacact ccgatttctg 829801 aggcaggcta tatgggagcg gctatggctg cggcatcaac cggtttgaga ccgattgccg 829861 agctgatgtt taacgatttt atcggcacgt gctttgatca ggtgatcaac caaggggcga 829921 aattccgtta tatgttcggc ggaaaagcgc aagtgccgat taccgtccgc accacatacg 829981 gagcagggtt ccgggccgct gcccagcatt cacaatcgct gtatggcctt ttcacgagca 830041 tccctggact gaagacagtt gttccatcca atccgtatga tgccaaaggt cttttgcttg 830101 cagcaataga agataatgat ccggtgtttt tctttgaaga caaaacgtcc tacaacatga 830161 agggcgaggt gccggaagat tattatacaa ttcccctcgg aaaagcggat atcaaacgcg 830221 aaggcaatga tgttacgctc tttgcagtcg gcaagcaggt caatactgcg cttgaagcgg 830281 ctgcacagct ttcagagagg ggcatcgaag ccgaggtcct tgatccccgc agtctgtctc 830341 ctctggatga ggatgcgatt ttcacatcgt tagaaaaaac aaaccggctg atcatcattg 830401 atgaagccaa tccgcgatgc agcattgcca cggatattgc tgcgcttgtc gctgacaagg 830461 gctttgattt gcttgatgcg ccgattaaac ggattacagc gccgcataca ccggttccgt 830521 tttcaccagt gcttgaagat caatatttgc cgacaccaga taaaattgtc agcgtcacgc 830581 ttgaattgct tggcgagccg gcattgaatt aaagggggga cacaaatggc ggtaaaagta 830641 gtgatgccaa aattgggaat ggccatgaaa caaggggaag tatcgatatg gaataaaaaa 830701 gtaggcgacc cggttgaaaa gggagaaagc attgccagca ttcaatcgga gaaaattgaa 830761 atggagatcg aagcgcctga aaaaggaacg ctgatcgata tcaaagtgaa agagggagaa 830821 gaggttccgc ccggcacagc tatctgctat atcggggacg ccaatgagtc ggtgcaggaa 830881 gaggcggggg cgcctgttgc tgaagacaat atgccgcaag ccgtccagcc cgtcaaacaa 830941 gaaaacaaac ccgcagcctc caaaaaagat cgaatgaaaa tatctccagt cgccaggaaa 831001 atagcagaaa aagcaggatt agacctaaaa caactgaaag gaactggacc aggcggacga 831061 atcgtgaagg atgacgtaac aaaggctctt gctgaacaga aaaaagatca agcaaagcct 831121 gtttcggagc agaaagcgca ggaaatcccg gtgacaggca tgagaaaggt catcgctgcc 831181 cgaatgcagg aaagcctggc aaacagcgcg cagctgacga tcacgatgaa agctgatatc 831241 accaagcttg ccactcttca aaaacagctt tcaccaactg cggaagagag atacggcaca 831301 aaactgacga tcactcattt tgtctcaaga gccgccgttc tcgctctgca agctcaccct 831361 gtgctgaaca gcttttatca aaatgagcgc atcatcacac atccccatgt gcaccttggt 831421 atggctgtag ccttggaaaa tggcttagtg gtgcctgtca tccgccatgc tgaaaagcta 831481 tcgctgattg aactggctca atccatctca gaaaatgcca aaaaagcacg cgagggacgt 831541 gcgggaagcg aagaactgca aggatctact ttctccatta caaaccttgg cgcgtttgga 831601 gttgagcatt tcacaccgat actaaatccg ccggaaacag gcattctcgg catcggagca 831661 agctatgaca caccggtgta tcaaggggag gagatcgtca gaagcacgat cctgccactc 831721 agcctgacat ttgatcacag agcgtgtgac ggcgcccctg ccgctgcatt cctgaaggcg 831781 atgaaaacat atttggaaga acccgcagca ttaattttat aggaaaagca ggtgaaaacg 831841 acatgacatt agccattatc ggcggcggac ctgcaggcta tgcggctgcg gtttccgcgg 831901 cacagcaggg cagaaacgtg ctgctcattg acaaaggcaa gcttgggggg acctgcctga 831961 atgaaggctg catcccgaca aagtctttgt tagaaagcgc aaacgttctt gataaaatca 832021 agcatgccga cagctttgga atcgaacttc cggcaggtgc gatatcagtc gattggagta 832081 aaatgcaaag ccgaaaacaa caggttgtca gtcagcttgt ccaaggcgtt cagtacctaa 832141 tgaagaaaaa tcaaatacag gttgtaaagg gaacagcctc ctttctttct gaaagaaagc 832201 tcttgatcga aggagaaaac ggaaaagaaa tcagagaggc ggaccaagta ttgattgcct 832261 ccgggtcaga gccaatcgag ctgccttttg ccccatttga cggcgaatgg atcctcgaca 832321 gcaaagacgc gctttctctt tccgagattc cgtcttcact agtcattgtc ggcggcggtg 832381 tcatcgggtg tgagtatgca gggctgttcg ccagattggg atcgcaggtg accatcattg 832441 aaacagcgga ccggctgatc ccggctgaag atgaagatat tgcccgtctc tttcaggaga 832501 aacttgagga agacggtgtc gaagtgcata cttcatccag attagggcgg gtggatcaaa 832561 cggccaaaac ggcaatatgg aaaagcggtc agcgagagtt taaaacgaag gccgattatg 832621 tgctggtggc gatcggcaga aaaccccgtc ttgacggatt gcagctggaa caggccggag 832681 ttgatttttc tccaaagggc attccggtga atgggcacat gcagacgaac gtgcctcata 832741 tttacgcgtg cggagatgct atagggggca ttcagctcgc gcatgccgct ttccatgagg 832801 gcatcatcgc tgcttctcat gcttccggaa gggatgtcaa aatcaatgag aaacatgtgc 832861 cgcgctgcat ctatacgtcc ccggaaatcg cgtgtatcgg aatgacagaa cgacaggcaa 832921 gaagcatata cggggatgtg aagatcggcg aattttcatt ttccgcaaac ggcaaggcgc 832981 tcattaaaca gcaagcggaa ggaaaggtca aaatcatggc tgaaccggaa ttcggcgaaa 833041 tcgtgggtgt ctcgatgatt ggcccggatg taaccgagct catcggccaa gcggcagcga 833101 tcatgaatgg tgagatgacg gcagatatgg cggagcattt tatcgccgcc catccgactt 833161 tatcggaaac attgcatgag gcgctgttaa gcacgatcgg ccttgcggta catgcataat 833221 aaaggaaaaa gcaggcgcat ggatataagg cgcctgcttt tttattgttg aaagcgcttt 833281 atttttcccc tacaatagat gaaaacggcg tgtaagggag gagcgatcaa ggaaatgaat 833341 tcggtcccaa acgatttgca aacctggaaa cgttttgtga aagacggtgt gcttgacgaa 833401 gcccgattaa gaaaacggat tgcagagtca tggcatcgct gcaaaaaagc tgaggtcaat 833461 ccttatttag aaaaaggccc gaaggtttta cagcaaacgg agctggatca gcagtcaaaa 833521 aaacattcat tcttcttgac gaccgcaaag ccttacctcg aaaaactgct gcctgccata 833581 aaagaaatgg aaatgatggc gctgttaatt gattcagacg gtgttgttct ggcattggac 833641 ggccatccgc gcgcgctcta tgaagccaaa cgcatcaatt tcgtcgaagg ggcatgctgg 833701 acagaaacgg ctgtcggaac aaatgcgatt ggcacggcgc tccacatcag cgagccggtt 833761 gcaatacaag gatcagagca ttactctatc gcttcccatc tttggaactg ttcagctgct 833821 ccgattcacc atgaggatgg cagccttgcg ggtgtaattg acatatcatg cccggcggca 833881 ggcgcgcatc ctcatatgct tggtattgcc acggcgattg cctatgccgc tgaacgggaa 833941 ctcgcagcta aaagccgtga gaaagagctg gagctgatca gccgttttgg ggagagagct 834001 gcatccagtg tgccgatggt gctctgtaat accaagcagc acatcatcag tgcgagcatg 834061 ccgattcgaa cctcaatgcc ggattggcag ggccggcacc tgtacgagtt gaaggaacgg 834121 ggctattcaa tcgaaaatgc tgtcaccata ggagatggcg gcacttgttt ttatctttcg 834181 gaacaaaaga aaaagaaggc gtttcgattc aatggagtga tcgggcaaag cggccgatcg 834241 caagcgatgc tgatgcacct tgaacgagca gctgcgacgg atgcatcggt ctgtttgtcg 834301 ggtgaaacgg gtacggggaa ggaggtcgcg gctcgcgcgc ttcatgagaa cagtgagaga 834361 cggcacggtc cgtttgttgc tgtcaattgc ggagcgattc cgtctgattt gattgaaagc 834421 gaactgttcg gatatgcaga gggcgctttt acgggagcga aacgaaatgg ctataaaggc 834481 gcctttcaaa aagcgaatca aggcacatta tttttagatg aaatcggaga aatttcccac 834541 tcgatgcagg ttgcactttt acgggtgctt caggaacgca agataacgcc aatcggcggg 834601 acgaaagaaa ttccggttga tatcagagtt attgccgcca cacattgtga tttacgcgag 834661 cttgccgaaa acggaaaaat cagagaggac ttgttttacc gtcttcatgt ctatccaatt 834721 gaactccctc cattacgcga tcgcaccgag gatatcccgg atctctttga gtactacaaa 834781 cagaagaatc attggccagg cgatcttcct tctgattttt gtaatgtgct gaagcaatgg 834841 aagtggccgg ggaatatccg cgagctgttt aatgtgtttg aacgtctttc tatcagattt 834901 ccggacggcc ggctgagaga tgaatcgctt cccgctttac tggaagccgc tggattgccg 834961 gccagctctg cagaaaaaaa gccggctgct gccggcgtgc ttacttttcg tgagcaaatc 835021 caaaaggata tgatgatcaa agcgcttgaa tctgcaaaag gaaacgtctc tcaagccgca 835081 aaaatcagcg ggatcccccg aagcactttc tacaaacgcc tgaaaaaatt caacttgtcc 835141 gctgaatcat aaagcatact tccttcagga aatggaaacg ttatgtattg aaggagggtg 835201 ttacgatgaa tattcaaagg gcgaaagaaa ttgtagaatc tcccgacatg aagaaagtaa 835261 catataacgg cgttcctatt tacattcagc acgtaaatga agaaactgga acagcaagaa 835321 tttatccgct tgacgaaccg caagaggagc atgaagtgca gctgaacagc ttaaaagagg 835381 attaaacaaa aatggcccgc ttcataagca ggccattttg ttatccgcgc ggcgcaaata 835441 aaataacaca gacaccgatg agacaaatga atgcgccgat ccagtcatac agatcaggtg 835501 ttttccggtc aacaagccat ccccacagga ccgcaagcac gatgaatact ccgccataag 835561 cggcgtatac acggccgaaa gatgggaagg actgaaacgt cggaagaatg ccgtatacaa 835621 tgaggatcag cgccccggcg attccgtagc cagctggctt tgcctctctc agccatagcc 835681 aaaccagata tccgccgcca atttcagcaa gccctgccgc gagaaataaa agaatggtaa 835741 tcagcatcat gagcactcct caatttgcat ttatctttca ttatagagga ggagagcttt 835801 taaagcttcg gatgattctc aaattccttc aaatacgctt ttcgctgaac ctctgtaaat 835861 tggctgatcc aattgttttg agcctcttca ttcaaatggg gaaggatata gcgttcaacc 835921 gcttcgaaaa acagcggatt cgtgatgatg ttccaggtcg ggattcgaac gattttgccg 835981 tctgttttct cgatgataat atcctcaaaa aagatccctt tcaaactgta ttgatggcgt 836041 cccatataaa gccgcttcac ctcggaaaac agcacgctgc gctttctcaa gaagatttcg 836101 ccactaggtc cggtctttat ggtgaaaatg acatttccac ggcttgtgaa cgcaggaaaa 836161 gccataaaga atgtgatcaa tccataaatc atcgccagta atccgccgcc caaataaagc 836221 agggcatatt tagattcaaa cgtgagggct tcagacacca gccagactcc cacaataaag 836281 gcgccccctg tagcgaggaa cagccaagcc cttagaaaca tcatgctttt tacttcaatc 836341 atgtgctgcc cctaaagctt cggatgattc tcaaattcct tcaaatacgc actgcgttgg 836401 atgtctgtaa actgtccgat ccaattgctt ttcgcctctt cattcagatg tggaaggata 836461 tagcgttcaa ccgcttcgaa aaacaacgga ttcggaatga tgttccaagt gggaatgcga 836521 atggtcttct gatccacggt ttggatcaat atatcttctt ggaagattcc ttttagacta 836581 aatttatggc ggctcatctc aattttcttg atatcagtaa acgtaacaga cactttgtca 836641 gtgaacactt ctccattttt tcctgtcttg atgcggaaaa tggtatttcc ccgcggggtg 836701 aaagccggaa agaagatgat aaataaatat aaacaaaaca aggtgaacag aaagccagca 836761 ggaatggcta ataggtaata tttcgtttga aacgtaatac ccatataaaa gagccacaaa 836821 catgctaatc ccataccggc agatccgaca aaagcccata ttctcaggaa cattttgctt 836881 ttgacttcaa tgatttcttg gtttttcaat gcttttctcc ttttgttaat tcaattctta 836941 tcattttgaa atgatttgat ttacaacatc cttatgagca gggaggatag aaaattcatt 837001 ctgggtgatg cctgtgacaa gccaagtatg gtgggccccc ggcaggacga atgccatgtc 837061 agccacttca ggagtgttat cttttccata tgccagacgc ataagtgtat ccattttccc 837121 tttccgcaaa gccagatcat ttgcaaatcg ggtaacgtcc tcttggtggt catgtttttc 837181 aaggaactct tttagatatg aagggttgtc tgaagcgccc tccaagagtt tttcaaattc 837241 atttgatgtc aatgttacaa tcgattctct tttatcctct gtatctatta tatgtaaaaa 837301 ctcatctgtc ttagcaagta acccttcact tgattccatt tttgtaatgc gatggacttg 837361 ttcatcaaaa aggagttcgt gagagtaggt gccgaatttt gatacatggc atgacacatt 837421 ctgttcggca ccttgcccgt taaatttaga aagcttcact gtatagtcag cgtcgtttaa 837481 tacatggata aacggacagt actcgtcctt taaccgatat tgatggttcc gatattccgc 837541 tgcatccttg gctaagagtg agcggcacgc ggcttcaaat aaggcgccga gctgttcatc 837601 ttctatttcc ggaaaatagg cctgcttcaa ggccattccc tgttcaaaaa acccttcgct 837661 gtaaaagcaa aacaagagtt cttctatgct aattgtaaac tgcttcattg tttattctcc 837721 tatccaaatg aaaatttccc tttaaggaaa tgggttgcgc cgtgtataag cgaatccgct 837781 gttttctttg ctttttccat tccttttttc gcgctgtcta tccctttatg tatcgattta 837841 ttcgccgcat ctatgccgtc attcactgat ttgacgactt tgccggctga ttccagccct 837901 tttttggctg tatcaacaac agcatggatc ggttctttca gctttaaggc tgctttttca 837961 gcaaaaccgg ctgtatattt ggcgatttgt tctccgacga ctccgccaat gtatgaacct 838021 gctgccccaa gaaggacagt acccacaggt cctgcaaagc ttccgattgc accgccgatg 838081 acagcaccag ctgtggcacc gccggcaaca aaaatcgtat tattcacagc attcccgacg 838141 gccttggcgt tttcacgctt gagaacttcc ggtttatcct ggtattttgc ataattttca 838201 gcaattttca cgcctgctcc gaatgtttcg gtcgctccgg taatcagtgt ggcggtaatg 838261 gcatttcctt tcgcgaatct caagcccgtt tttcccacat ccttcaaagt ggagcgtacg 838321 ccggcttcat taagaaatcc ttttgtgtag cttctgacgc tgtttgaaaa atccaccgtg 838381 tcctgaggaa agtattttgt aaacttttta tgtaccaaat ctgaaaatgg acggtttgtc 838441 tttttcaaca aatatttagg attcaaaagc actcttgccg ctttttgata acgtgagctg 838501 tcaacggccc tggaaatatc caagagcagt tttgagtgct gggctgtatg caagccgctt 838561 ggttgtttca caaatttcgt aagccctaat ccgtaatatt ttccctgcgt cagcataaga 838621 gcggttaagc ttgtcatcgt accgtatttg tcgtaggcat tgtagagctt tcgcaaaata 838681 tcatcttgtt ccacaaattt atcgcctgtt tttctgatga aaatctcatt gtcactcagc 838741 ttagtgacga gcgcctttcc tgagctccac gcatcgccca ctccagaaaa acagctgctg 838801 tagcggggat cgcattgcaa aatcatctgc cccagctcca catgcaggtc cttatatttg 838861 ttttccatat cagttaattc agtgactaca tcatttgcaa gctgttcgag cttatccgga 838921 tcaactgcaa tgtttcctga cacaccgttc acctcccgag tttatgtctt tcctctcttg 838981 ctttacgctc cagttcttcc attctggcaa tttcagcttt tcgttcttct attttgacag 839041 cggcagcctt cagctcttgg cttgtttcaa gcagctcctg ttcgaattga tcgtaggcgg 839101 ctttcgtttc ctcgaaatcc tggtcaaacg aatctcttgc tttgccctgc caagcatctc 839161 ccaatgcaga taaccgggat tcaagcagca ttttggagct tctgacctct tctgcggccg 839221 cactatactt gtttgccagc tcaatgactt tatatgagtc caacttttgt cccctgcctt 839281 ttctaaattc acgcacaatt ggatgtttta tataaatgat tataaataat tcggcatgta 839341 tccgaatcgt acaaaagaac cttttcataa gaattggaag ggcgtatatt cacttaaaat 839401 tcacagttgg tgagacttta agattacaaa aaaggtaaaa aaaccaaatc tctcagacat 839461 aaggcaaatg agaaatttcc cgctctatgg gaaaaaacac taaagttgat caaatgacct 839521 aagtgcgcca aacgtgttac gggacgagct atctcatggt ataaatggaa ttgtaaacgt 839581 tatcaaggag gtcgtcatat gaagaaaaaa tcattctcaa tcgtaatagc gggcggaggg 839641 agcactttca ctccagggat cgtactcatg ctcttggacc atttggagga gtttccgatc 839701 agaaagctga agctgtatga taatgataag gagagacagg atcgaattgc aggcgcctgt 839761 gacgttttta tcagagaaaa agcgccggat attgaatttg cagcgacgac tgacccggaa 839821 gaagctttta cagatgtcga ttttgttatg gcgcacatca gagtagggaa atacgcgatg 839881 cgcgcgcttg atgagcaaat tccgttaaag tacggagttg tcggccagga gacgtgcggg 839941 ccgggcggga tcgcatacgg tatgcgttcg atcggcggtg tgcttgaaat attagattac 840001 atggaaaaat actcgcctga tgcgtggatg ctcaattatt ccaatccggc ggcaattgtg 840061 gctgaagcta cgagacgcct tagaccgaat tctaaaattc tcaatatctg tgatatgccg 840121 gttgggatcg aagaccggat ggcgcaaatt cttggcttat cctcaagaaa agaaatgaag 840181 gtccgctatt acggattgaa tcatttcggc tggtggacat cgattcagga tcaagagggc 840241 aacgatttaa tgccgaagct gaaggaacat gtatcccaat acggttatat tccgaaaaca 840301 gaggctgaag ctgtggaggc aagctggaat gacacgttcg ccaaagcgcg tgacgtgcag 840361 gctgcagatc ctgacacact gccgaatacg tatttgcaat attatttgtt cccagatgat 840421 atggtgaaaa aatcaaatcc gaatcatacg cgggcgaatg aagtcatgga agggcgcgaa 840481 gcttttattt tcagccaatg tgacatgatc acacgtgaac agtcctcgga aaacagcgaa 840541 attaaaatcg atgaccacgc atcgtatatc gttgatcttg cccgggcgat tgcctacaac 840601 acaggtgaaa gaatgctgtt gattgttgaa aataacggtg caattgcgaa ctttgacccg 840661 actgcgatgg ttgaggtgcc atgcatcgtc ggctcaaatg gacctgaacc gattaccgtt 840721 ggcaccattc cgcaattcca gaaagggctc atggagcagc aggtatccgt tgagaagctg 840781 actgttgaag cgtgggcaga gaaatcgttc caaaagctgt ggcaggcgct gatcctgtca 840841 aaaacagtgc cgaacgcgcg tgtggcaaga ctcattcttg aggatttagt ggaggccaac 840901 aaagacttct ggcctgagct tgatcaaagc ccaacccgca tatcataaat gaaattcccc 840961 cattttcgaa tctgtaattg tatataatag aaagaaaatg gggggatctg atatgcagct 841021 cgaagaactg atcaatcagc actacagcaa attgaatgac aacgattttc atattttaaa 841081 atatatattg aatcataagc acacatgcta tcaccttgga atcgacgcgc tggccaaagc 841141 ttgcagtgta tcgcgttcct caattttacg gcttgcccaa aagctcggtt tcagcggtta 841201 cagtgaattt cgcgtctttt taaagtggga agatcagccg gaagaaggcg agagtatgag 841261 ttttgaaaag ctgcttgatg atattgaagc aaatttgaag tttttacgga caaaggacat 841321 gacggacatg tgccagctga ttgatgcagc tgaccgcatt ttcgtctacg gttctggaaa 841381 tgcgcaaaag atatgcgccc gcgacctgca aagaatgttt attccgcgcc atcgctatct 841441 tattttgatt gaagacacaa atgaatttaa tttgatgcgc gatgatttta aagtgaacga 841501 tctgtttatc atcatttctc tttccggaga aacaccggag ctgattcctc aggcaagaat 841561 gctttctgca aagggtattc cctttatttc cattacgaat ttaaaaaaca atgtcctcgc 841621 ccagctgact ccgcataatc tttatgcgac aagcaaacct gtgacattaa gcgatagaac 841681 ggaaattgtc gcttttgcac cgttttttct cgttggcgaa gcattgttcc gcgcatatgt 841741 tgattacaaa gaggcagaaa aaaatgacaa tgagtagcag ggggttctgg tatgatgcaa 841801 aaaattcagc gctttggaag cgcgatgttt gtgcctgttt tattattcgc gttcgccggc 841861 attatcgtcg gtatcagcac gctctttaaa aataaaaccc tcatgggacc gctcgccgat 841921 cctgacggtt tttggtatca gtgctggtat atcattgagc agggcggctg gactgttttt 841981 aaccaaatgc cgctcttatt cgccattggc atcccggttg ctttggcgaa gaaagctcag 842041 gcacgcgcct gtttggaagc gcttactgtc tacctgacat tcaactattt tgtcagcgcg 842101 atattgacgg tatggggagg agcatttggc gtcgacatga atcaagaggt cggcggaacg 842161 agcgggttaa cgatgattgc gggcataaaa acgctcgata ccaacatcat cggagccatc 842221 tttatttctt cgattgtcgt ctttttgcat aatcgctatt ttgataaaaa actgcccgat 842281 tttctcggca tctttcaagg ctcaacatat atcgtgatga tttccttctt tattatgatc 842341 ccaattgcgt tggctgtgtc ttatatttgg ccgatggttc aatcgggaat cggctcgctt 842401 caaagcttcc tggttgcttc tggggcggtg ggcgtttgga tatacacgtt tttggaacgg 842461 attttaattc cgaccggcct tcatcacttt atttacacgc cgtttattta tggcccggct 842521 gtagcggaag gcgggatcgt cacgtattgg gcacagcatc tcggcgaata ttcgcaaagc 842581 gccaaaccgc tgaaggagct ctttccgcaa ggcggattcg cgcttcacgg caactcgaaa 842641 atcttcggta ttccgggtat cgccctggct ttttatgtga cagccaaaaa ggaaaagaaa 842701 aaactcgtcg cagggctgct gattcctgtc acactgacag cgattgtcgc cggtattaca 842761 gagccgattg agtttacgtt cttattcatt tcacctttct tatttgcggt tcacgccgtg 842821 cttgccgcca caatgtcgac agttatgtat atggccggcg tcgtcggaaa tatgggaggc 842881 ggactgattg aggcggtaac cttgaactgg attccgctct ttggcagcca cggtatgaca 842941 tatgtgtatc aaattttgat cgggctctcg tttacagcaa tttatttttt cgtcttcaga 843001 tttttaatcc tcaaattcaa tatcgctaca ccaggacggg aaaaggatga acagcaggaa 843061 acaaagctat attcgaaaaa ggaatacaga gaacgaaaaa acaaggatga aacggcctcc 843121 gctgctgaaa cggctgatga caccgctttt ctgtatattg aagcgctggg cggaaaagac 843181 aacatcactg aagtcacaaa ctgcgccacc cgcctcagag tcagtgtcaa ggatgaaaca 843241 aaggttgaac ccgacagcgt attccgcgcg cttggcgcac acggcgttgt caggaacggg 843301 aaggcgtttc aggtaattat cggattaagc gtgccgcaga tgcgggagcg tgtggaaaaa 843361 atattgaatc aataaagact gccctccttt tcgggagggt tttcgtttgc cgtcaaaaag 843421 accgccatag taaagtaaag aaagagacaa tcgagtaaaa aggggtttgg aggcttttac 843481 atgcaaaagg ctttgtcgtt tttaaaacca tattcattgc tggcgggaat tgctctgatt 843541 cttatgctga cggagcttgc agttgaactg atgcagcctt tattgattgc aaaaatcatc 843601 gacgatggga tattgaagca agatctgcgg catgtatgga tatggggcac ggtcatgatc 843661 gggctgaccg tgttatcctt tgcggcgggg atgctgaatt ccttttatgc cgcccatgtc 843721 agccaaagct tttcctatga tacgagaaaa gggctttttc aaaaaatcca gtccttctcc 843781 tattccacat ttggacagtt ttcgtcctct tcttatatta caaggctgac aaacgacgtc 843841 acacaggttc aaaatatgat ttttatgagt ttgcggttta tgctgcgggc tcccttaatg 843901 attgcaggcg gcattgtgct gtcgcttgcc gttaatgtga aactcgggtt ttttctgctt 843961 gtgaccattc cgatcctgat cttgtttttg ctatgggtat taaggaaagg cggggcactg 844021 ttccgctcag tgcagaaaag gctggatcaa gtgaacacca tcatgcagga aaatttaatt 844081 gcaatcaagc tgatcaaagc gctgcttcgc ggcagccacg aagtcaaacg atttatcaaa 844141 gccaacacaa ggctgatgga aaaaacggtt tcggcctttc agcttgtgga attcacgatg 844201 cctgtactga tgctgctgat gaatctctgc atccttttga ttttgtgggc ggggtcctac 844261 agtattacga gcggaagcac tcaggttggc gatgttgttg cgataattaa ctacgcaaca 844321 cgaattacag gcgcgctttc gatgtttccg tttttgatta tgattttcac ccgggcgaag 844381 gcttcagggg atagaatcgg tgaggtgctt gaaacagaag gcgacgagcg ggaggaaggc 844441 accatatctg atcgtttgtc aggacggatt gagtttcagc atgtatcctt tcgctatcct 844501 gaaatggaca gagaagcgct caggaatgtc tcattttccg caaagccaag agaaacgatc 844561 gcgattctcg gtgcgacggg ctcgggcaag tccacgcttt ttcagctcat tccgcggctt 844621 tatcagccgg attcaggccg catttacata gatgaaaagc cggttcaaga tattccggct 844681 gaagggctgc gcaggcaaat tggatatgta ccgcaggaag tcctcttgtt ttccggcaca 844741 atcaaagaaa acatcgcttg gggcaaagaa aatgcttcac tagatgaaat aatggatgcg 844801 gcaaaacttg cgcaaattca tgaaacgatt ttaaagctcc caaatggata tgacactgtt 844861 ttggggcaaa gaggcgtcaa cctgtccggc ggccaaaagc agcggatttc cattgcgcgg 844921 gcgctgattc gaaaaccggc tatccttcta ttagatgaca gcacaagcgc gcttgatctg 844981 caaacggagg cgaagctgct tgaagcaatc agcacatacc attgcacaac tttgatcatt 845041 acacaaaaaa taaccacggc gatgaaagct gatcagattt tgctgcttga ggacggcgaa 845101 ctgattgaaa aaggcactca cagtgagctg ctttctgaat ctcagttata caagcgcatt 845161 tacgagtcac aattcggaag ggaggggagc gagtcatgct aaaagacatc cgcaagcctt 845221 tccaatatcc caaactgcca attgacaaaa aagaaggcgc gaaaaagcgg gcgaaagcaa 845281 aggatacaaa gggcacactg agacgaatct ggtcttactt ggctgaaaga aaaggactgc 845341 tcatacttgt catgctaatg gttgtcatca gcgccatatt cggactcctt ggtccctttg 845401 tgatcggaaa ggccatcgac cattttatcg tcgggaaaac ggtcagcggc ttgattcctg 845461 ttttgcttct tctgctcgct atctatatca ttcagtccct gtcgctttgg tttcaaaact 845521 attggatgat tacgatctcg cagggcacgg ttttcagaat gagaagcgaa ttgttcaccc 845581 atctgcatga gctgccgatt ccattttttg ataaacagcg gcacggcgag ctgatgagcc 845641 gggtgacgaa tgacatcgaa aatgtcagtt ctaccttaaa cacgtcagtc attcaaattt 845701 tgtcaagtgt gatcaccttt gtcgggacga ttgcggtgat gctgtacatg agcccgctcc 845761 ttactttgat tacgctgacc attattccgg tgatggcagc gagcctgaaa tggatcacca 845821 accgaacggg aaagctgttt aaagaacagc agaaaaacct tggtgatctg aatgggtata 845881 ttgaggaatc tgtttcaggc gcaaaggtca tcaaagcata ttcacgtgag aagcagatta 845941 ctgctgaatt cctcgaaaaa aacgctgcac tcaagacgtc gggcttttgg gcgcagacga 846001 tttccgggtt tattccgaag gtcatgaact ctttgaataa cttaagcttt acaatgattg 846061 cggcaatcgg cggtttgttt gcgctgaaag gctggatctc gatcggctcc atcgttgtct 846121 ttgccgagta ttcaagacaa tttacacgcc ctttaaacga tctggccaac cagtttaata 846181 cgatgctgtc cgcaatcgcc ggcgctgaac gggtgtttga cgtgcttgat gaaaaagaag 846241 agcgcgagga tgaaaagaac gccgtgcatc agcccatcca aacaggcagc attgaattcc 846301 gggatgtgtc cttcggttac gataaagggc agcagacact gaagcattta cagtttaccg 846361 tgcctgcggg gcagtccatc gcgtttgtag gaccgacggg ggcggggaag acaaccgtca 846421 ctaaccttct cgcccgtttt tacgagccta acgatggaaa aattttaatc gatggtacag 846481 atattaaaac ccttactaga gcaagcctaa gaaaaaacat ggggtttgtt cttcaggatt 846541 ctttcttatt tcagggaacg atcagagaaa acattcgcta cggcaggctt gatgcttctg 846601 atcaggaagt cgaagccgct gcaaaaacag cgaatgccca tagttttatt gaaaggctgc 846661 caaaagggta tgacaccgta ctgacgcaaa acggttcggg catcagtcaa gggcagaagc 846721 agttgatttc tatagcgagg gcggtgcttg ccgatccggt tcttctcatt ttggatgaag 846781 cgacaagcaa cattgatacc gttacagaag tcaacattca agaagcgctc gcccgtttaa 846841 tggaaggaag aacaagcgtc atcattgccc acaggctgaa caccattcaa agagcggacc 846901 agattgtggt gctaaaaaac ggtgaaatga ttgaaaaagg cagccatgac gagctgattc 846961 ggcaaaaagg attttacagt gacttatatg aaagccaatt tgagaaatag acctttgtcc 847021 tgcacagagg tctttttttg ttacagtttt atagtacttt tatttcattt tcgtaaaatg 847081 taacaaaatt acttgacgta aacaagttat gtatatatac tagcttacat taagtaagtg 847141 ataacattta tcaaggagga taaaatgaat aaatcatttg aaattggcac attactttta 847201 agagttatta caggtattat cttttttgtt cacggtttat caaagtttca gggaatggag 847261 ggcaccatcc aatttttcgg cagcataggc cttccaagct ttatggcgta tgtcatcgca 847321 gcgattgaac tgattggcgg agtgcttgtc ttcttcggat tggctacacg tattgtcggt 847381 gtactgttcg ctcttacact gatcggcgcc atcatcactg ttaagctgaa agcgccattc 847441 atgggcaatg cagaatttga ttaccttctg cttttgacat ccattcacct ggcgcttact 847501 ggaagtcgat tcctggcgct ggacccattt gtgtttaaag gaaaaaagaa cggaaacgtt 847561 tcagcataag aaaagaggca tgcagcatga ccagcattca tgaggataca cacattggct 847621 atgccaaact cacaattcgc agtctggagc gttcgcttca gttctactgt aacgtcatcg 847681 gttttcaagt cttaaaaaag acggaccgcc aagcggaatt aacggctgac gggaaacgcg 847741 tactgcttat tcttgaagaa aatccgagcg ctgtcgtctt gcctgaacgg tctgtgacag 847801 gcctttatca ctttgcgatt cttcttccgg acaggaaaga acttgggatc gcgctcgccc 847861 gcctgattga acacggcatt gctatcggac atggagacca tgctgtcagc gaagcgctct 847921 acctgtctga tcctgacgga aacggcattg aaatgtacgc tgaccgcccc cgcagcacgt 847981 ggcagcgtga tcgggaagga aactacgtca tgacgacaac cgctgttgac attgagggcc 848041 ttctggaaga ggcaggagat gagcggaaaa catcgcttcc gaacgataca atcatcggac 848101 acattcatct gcatgtcagt gatttgaaag aagcaaaggc gttttataca gatgtactgg 848161 gctttgacat tgtcggaaac tatgcgggca tgtccgccct cttcgtttca gccggggggt 848221 accaccatca tatcggctta aacatttggg cgggaagaaa tgcgccgcct aaaccgacaa 848281 atgccagcgg actagattat tatactgttg tcctgcccca ccaagaggag ctggatttgg 848341 tggcaaaccg agtcaaacat gccgggtatt cgattgaaga gacggaaaac agctttcgtg 848401 tgaaagaccc tgtttccggc gcctatatta catttgtgat ttaactgcaa tccccttgcc 848461 gaaataacgg cagggggatt ttttattttt gtccgccttg ttatgatgag agaaccaact 848521 tgttaggagg cgtttacatg gaactcaacc accttgtgac gggcaaaata gcattaaatc 848581 aatatgtgca tcgcttagag caaaaggatg tttcatttta cgtccactac tggggagcga 848641 tgacgaacca ctataacaca ctgcttcata agcattcctt ttatgaaatt tgttacgtgg 848701 taagaggtga aggatattac cttgaaggcg atcgtacata tccgcttcgt gaacagacga 848761 tttttttgtc aaagccggag catttgcacc aaatcaaaag tgaaacaggg ctgttccttt 848821 tttacgtcgc tttcgagctg agcgaggatc agtcaagcgc cgaatggatc aaagtgatgg 848881 aagaagtgaa acaaagcccc tttatcacaa tgcaattgaa agatggcgaa ccgccgggcc 848941 tgctttggaa aacgttaatg ctgcaagcag cgcaacctgt caatgctttt gacaaagaga 849001 tcctatctca tttgtcgcat gcattgatcc tgtcattaat ccaaaccttt ctcccgtacg 849061 cccaacgccc gaaacaaaag cagcccattc acacatcttc tgctttgctg acagaggtga 849121 aactgcacat aaaagacaat ctgtcacagc cgttaaagct gacggatgtc gctagccact 849181 ttcatatctc agggaggcat ttatcacgtt tatttgcagc agaactgggc gtcagctact 849241 cagaatttgt ccaaaatgaa aaaataaaca aagctgccga actgctgaaa tcaacgaatt 849301 tgtcgattaa agaaatagcg gaagaaatcg gtttctcagt acattatttc actcgcgtct 849361 tttccgctaa aatcggcagc tctccagggc ttttccgctc cctttataaa gactcaaaaa 849421 tgaccgcatt tcaaatcaat aaaccttttc aaaaaatcga acaggccaag ccgcacgaat 849481 aagatgtcct gaaatgacaa aacaatgtct tcatatgata aagacgcgag aaatctcgtt 849541 gtcttataat ctttttagaa agcggttaca acaaggggta ttgctgaagg agggatgcat 849601 tggcttatgc ttggtgtcgg gtgctctgcc attcttgaaa gaaggggaag aaagccgtga 849661 gtacaaaaaa gaaagaggct gtaataggaa aagaaagctt agctcataaa gggcttttac 849721 gaacgattac attggtatct acattcggcg gcctgttgtt cggttatgat acgggtgtca 849781 ttaatggggc acttcctttt atggcaactg caggtcagct gaatcttaca cctgttacag 849841 aaggactggt tgcgagttcc ctgcttctcg gggcagcctt cggggcgatg tttggaggac 849901 gtctgtccga tcggcacggc cgccgaaaaa cgatccttta tttagcctta ctcttcatcg 849961 cagccacact tggctgtacc ttttcaccaa acgcgtccgt gatgattgcc tttcgttttc 850021 tgcttggact ggcggttggc tgcgcttctg taacggttcc aaccttttta gcggaaattt 850081 cgccggcaga acgcagggga cgaatcgtga cacaaaatga actgatgatc gtaattggcc 850141 agcttctggc atacaccttt aacgccatta ttggcagcac aatgggggag agcgcaaatg 850201 tatggcggta tatgctggtc atcgcgacac ttccggctgt tgtgttatgg ttcggaatgc 850261 tcatcgtgcc tgaaagcccg cgctggctgg cagctaaagg cagaatgggt gacgccctgc 850321 gggtgcttcg gcaaatccgt gaagacagtc aggcacagca ggaaataaaa gaaatcaaac 850381 atgcgattga gggcacagca aaaaaggccg gctttcatga ttttcaagag ccgtggataa 850441 ggcgcattct attcattggg attggaatcg ccatcgtaca gcaaattacc ggtgtcaatt 850501 cgattatgta ctatgggaca gaaattctga gagaagccgg ttttcaaaca gaagctgcat 850561 taatcggcaa tattgcaaac ggtgttattt cagttattgc ggtcattttt gggatatggc 850621 ttctcggcaa agtccgtcgc cggcccatgc tgatcatcgg acagattggc acgatgacag 850681 cccttctgct gatcgggatt ttatccattg tccttgaagg aacacccgcc ctgccgtatg 850741 ttgtgctgag tttgaccatt ttgtttcttg cgtttcagca gactgccatt tctacggtga 850801 cgtggctgat gctctcggaa atctttccta tgcatgtgcg ggggcttggc atggggatca 850861 gcaccttctg cttgtggaca gctaactttc tcattggatt cacctttccc attttgctca 850921 atcatattgg gatgtcggcg acatttttta tctttgtcgc tatgaatatc ctagcgattc 850981 tatttgtgaa aaaatatgtg cctgagacaa aagggcggtc acttgaacag cttgagcatt 851041 cctttcgcca gtatggccgc cgcgctgatc aggaaatcca aaatcaaaca actcacttat 851101 cgtaacctga gataccagga ggaatctatc aatgaaacta tcttatgtaa cagacagcct 851161 agggcatttg ccttttgaag acatgctcaa ttttgccgca aagcttggga tcgatacact 851221 tgaaatgaca accgggggct ggtcgccggc acctcacttg aatcttgatg aattgctgca 851281 aagcagcgaa aaaagaaaag aattttcaca agcgctggaa aagcggaaca tgacactttg 851341 cgcattaaac tgctcgggga accctttaga tccgggtgaa ttgggcaaat cgcacagaga 851401 cataactgac aaaacgatgg agctggctgg attattaggc gtcaaaaaag tgatcatgat 851461 gagcggtttg ccagccggcg gcccggacga caaagtgccg aactggatca catacacagt 851521 aagctggcct cccgttttaa aagatatcct caactatcaa tgggaagacg ttgcgatccc 851581 atattggaag aagcttgtca aaaaagcgga ggcctgcggc gtggggaaaa tagcgcttga 851641 gaacttcagc tctcaattag tctataatcc tgagactctc tttcggctca gaaatgcagt 851701 cggcccgatg gtcggtttga atcttgaccc gagccatttg ttatggatgg gcgcagaccc 851761 gatcatcgca gcaagggagc tcggctcagc cattcaccat gtccatggga aagatgtcag 851821 aattgaaaga tatttatcgg cggtcaacgg acttttagaa acaaaagaag tgacagatcc 851881 tgcaaaccgg gcgtggaatt acgtagctgt cggctgtgga caggatttac agtggtggaa 851941 ggaatttttt tcagttgtaa aaatgatggg atatgaaggt gaggtttctt tagaaatgga 852001 ggatctgacg atgtcacctg aagcgggcat ccgtacttct gtagaagctt taaaacaaac 852061 catcagccaa taggaggttt tcatgatgct aaatggagaa agaatcatct ctaagccgct 852121 tcgctgggca atggtaggcg gcgggcggct cagccaggtt ggatataaac atcgtattgg 852181 agcgctgaga gacaatactg cttttcaatt aactgctggc gcttttgata tcgatgccga 852241 aagaggaaaa gatttcgggg tgaaccttgg agtggatgcg gaacgctgtt atcccaacta 852301 tcaaaccatg tttgccgagg aagcgaaaag acaggatggc atagaggtag tatcgattgc 852361 cactccgaac ggcactcatt atgagatttg taaggcggcg cttgaagcag gagtgcatgt 852421 catctgtgaa aaaccgctgt tcttcacttc agcagagggg caggaaatca aagcgctcgc 852481 agagaaaaaa gggaaaattg tcggcgtgac gtacggtttt tcaggcaatc aaatgcttct 852541 tcaaatgcgt gcgatgattg aacaaggaat gatcggcgat attcgcgtgg ttgacttgca 852601 gtacacacac ggtttttgtg caacagatga aggtgaaaag ataagcgctg cacagaaatg 852661 gcgtgtcgac cctgcgatcg ccgggccaag ctttgtgctg ggcgatttat ctacccacac 852721 gtattatatg tcacagctta ttatgccaaa gatgaaaatt aaggagctgc tgtgtgaccg 852781 acagagcttc gtcggcagcc gcgcaccgct agaggataat gcccatgtgc tgatgcatta 852841 tgaaaatgga gcggtcggaa cgatgtggac atcgtcaatc aatgccggat gtatggatgg 852901 ccatagaatc cggattgtcg gctcaaaggc aagcattgag tggtgggaca gcaagccaaa 852961 tgaactgacg tatgaagtgc agggagagcc gggccagaca ctcgttcgcg gcatgccgta 853021 tttagatgat gtttgcaacg ccgatgaacg actgggcgcc ttacacagcg aagggctgtc 853081 cgaagcatgg gccaatattt atcttaaatt tgccattgcg atagacgcca aaaaccgtga 853141 agatgaagaa atcttgaaca acttggttta tcctgacatt gatgcaggga tcgagggcat 853201 tcgctggatt gagaactgcg tgcgctcggc aaaccaaggg tcagtttggg ttgaatttaa 853261 ataaatgagg gaatgcgccg catatgacat aaagttcata tgcggttttt attttccaga 853321 aactcctgtc aaaaatgccc tgaggcaggt atgataagaa gggaattggg tatcgggagt 853381 gatgagcgtg aaagctcttt tttttacgag aatgttcacc ttgatggtga gctgtttaat 853441 gtatctgtcc attgtgaaag aggataactg gtttggatat gtatttatag cagcaggtgc 853501 tgccatgtat gcagccaatc atgttttgct gacaaaagag acaaatgcca tctggttctg 853561 cctgattgat attgcaatcg gcttttcgtt cggatttatc tttcccggca caggtttgtt 853621 cattattatg ctttgtccgg ttgcggtcgc cttttttctg cgggggtttc ctaaaagaac 853681 agcatggtct gtcttatgtc tttcctctat tttatttttg accgtcctca tccgtacata 853741 tgcgatgttc ggcaatgaat ttgtcattga tcatttgact agcatgacat tcgttgtctt 853801 ctgcggtgtc gtgggcaaat taatccgcaa gctgttggat gcgcaggata cggcaaaaca 853861 gcagtttcag gaactgacgg agtcccatct ggcgctgtct gctgcacatc aggagctcca 853921 tttatatgcg aagcaggttg aagagctgac tgccatttac gagcggaaca gaatggcgcg 853981 tgaaatccat gatacagtgg ggcataaaat gacggccctt ctcgtccagc tgcagctttt 854041 gcgtgaatgg caaaaaagag acagccaaaa agcggatgag acagtaggtg tctgtgaaac 854101 acttgcccgt gaagcgcttg atgatgtccg cttatcagta cgcactctgc aaactgaaaa 854161 cgatccttcg ctaatcgaat cgctgaaaca gctgacagag gacttttgca aaaatgcagg 854221 agtcacaaca gaatttgcgg tcagcggtga tcctgcaatc atcccgctgt ctctccatcc 854281 gaccctgatc agaacggtgc aggaagcact gaccaatgcc aaacggcacg gcggcgccgc 854341 agcctgttcg atacagcttg cctgcacaac ggacagcatc agccttgtca ttaaggatga 854401 cggcaaaggc aatcctgagg cagcacttgg ttttggtctc ttgaatatga aaaagcgggc 854461 agcggagcat ggcggaatga tccgctttga aagcgaacgg gatcaaggat ttactgtaaa 854521 tgcagaattt tcacttgcca ataaaaaatg gagcttcggg cccgtgcagc aaaaggagag 854581 tttatcatga ttaagatcat cattaccgac gatcaggata tcgtcagaga agggctggca 854641 tccctgctcc agctccgaga agagctcgat gtgatcgcaa cggcgcgaaa cggacaggaa 854701 gccttcgaaa aggcgaaaga gctggagccg gatatcgtgt taatggacat ccgcatgccg 854761 gtttccaacg gggtggaggg aacaaaatta atcacaagct cgctgccaag cgtaaaggtt 854821 ttgatgctga caacctttaa ggattcagcg ctgattgctg aagcgcttga agagggagca 854881 agcgggtatc tgctgaagga tatgtctgca gatacgattg taaaagcagt gatgactgtt 854941 cattctggcg gaatggtgct tccgccggaa ttgactgccc aaatgctgaa tgaatggaag 855001 cgtgaaaaac agctgaaagg aataaatgag atagaaaaac ctaacgagct gctcgacctg 855061 accgagcgcg aaatcgaagt tctggctgag ctgggatacg ggctgaataa caaagaaatt 855121 gccgaaaagc tttacattac agaaggcaca gtcaaaaacc acgtttcaaa tattatcagc 855181 aagctggctg tcagggacag aacccaagcc gccatttact cggtcagata tggtgtatct 855241 gtcttttgac atatgacgtt ttgcatatac gcttctctga aaaggccttt tacaggcctt 855301 tttttcatgc cctatgttct atctgccgct acatgccgca cgcctttctt tcttctacaa 855361 tggcaatgga tcaaaaaaag gagtgagacg acgtgctgca agcagaaaac atcaaaaagg 855421 catacggaaa aaaaacaatc gtgaaaggca tttctttttc cctcaaaaag ggggagtcgt 855481 tcggtctgct cgggcctaac ggtgcgggga aatccacaac catctcgatg atttccggcc 855541 ttgtgccgca tgacagcggg aacatcacgg tgggcggcta tgttatcgga aaagaaacgg 855601 ccaaagcgaa acaaaaaatc ggcattgttc cgcaggaaat tgcattatat ccgacgctga 855661 cggctcatga gaatcttatg ttttggggga aaatgtacgg acttacgcac ggtgaggcca 855721 aaaaaagagc ggctgaggtc cttgaatatg tcggtctgac tgagcgggct aaagataaga 855781 ttgaaacatt ttccgggggg atgaaacgaa gaatcaacat cggtgcggct ttaatgcata 855841 agcccgagct gctgattatg gatgaaccga ctgtcggtat tgaccctcaa tcgagaaatc 855901 acattttaga aacggtcaaa cagctcaacg aaacgggcat gacggtgatc tatacgagtc 855961 attacatgga agaagttgag tttttatgcg accggatcgg gataattgat cagggggaaa 856021 tgattgcgat tggcacaaaa actgatttgt gcagccgcct tgggggcgat accatcattc 856081 agctcacggt cagcgggatc aatgaagcgt ttcttgtggc gatccgatct ctggcccatg 856141 tgaatgatgt aacagtacat gaattagagc tcaaaattga catttctgcg gctcatcatg 856201 agaaagtcgt cacaagcctg cttgctgaag ccactgctca tcatataaac ctgctgtctc 856261 ttcaggtgca ggaaccgaat ctggagcgcc tgtttctgaa tctgaccggc cgcacgttgc 856321 gggattgagg agggacggca atgaaaaaaa gcatatggat cgcatggaaa gatgtgaaaa 856381 tcagaatcac ggacagaaaa gggtttatga tgcttatcct aatgccgctc atcctaacct 856441 gtattttagg cgcagcgctc ggatcagttg ttgacggagg cagccggatt gatgatatca 856501 aagtcggcta cattcaatca gaccagtcag atacagcaaa catgtttaca aaagatgttc 856561 tcaaaaaaat gaagtcgata aaggtcacaa aagtcggcag caaagacaag atgaaaaaac 856621 tgattgatga aaagaaaatc gatgtaggca tcgttatccc gaaccattgg gaagccggca 856681 aaacctcagc tgttgttaat gccgctcctg atcaaacatt gaaaagttcc atcattgaaa 856741 cagctgcaag ctcatttata gagcaatata aagcggtaaa ggaagccgcg tcaggctcaa 856801 tggactacat cagtaaaacg gaagctgtaa agcaaggaaa acttgaccct gcacagtttg 856861 cagaaaagct ggcaaagacg ctagaaaaag aaacaggtga caagcttact attgcggaaa 856921 aatctgtcgg cagcaaagcc gttaccagtt ttcaatacta ttcggcggca atgctttgca 856981 tgtttatgct gtttcatatc acagtcgggg cgaaatcatt tttacaggaa aaggatacgg 857041 agacgcttgc cagaatgctg atgacgcctg cgcaaaaatc cgtcattctc ttcggaaaat 857101 ggcttgggac gtatctgttt gccatcatac aatttttcat atttctgatc gtcacaatca 857161 acgtatttgg tgtggactgg ggcggtaatc tgctgttagt gagtgtactc gggctttctt 857221 acgccgcagc tgtatctggt atttcaatgc tgcttgcgtc gtgcatcagc gatatgaaaa 857281 ctgcagatgc gataggcggc ttcggcattc aattgcttgc ggttctcggc gggtccatgc 857341 tgccgctgta ccaatttccg gacgtcttgc agtctgtatc caaagcggtg ccaaatcgct 857401 gggcgcttga cggctttctt tctttaatgg aagggggagg ctgggctgac cttcaaaagc 857461 ctgtgcttct ttttgcggcg atcggctttt gttcacttgt aattggtatc agacggcttc 857521 atacaagata aggaggtaca aaaggtgaaa aaaattctag ccatttgcgg cattgagctt 857581 tctctcattt ttaagaagcc acagaactat ttgatcatgt ttgctgcccc gcttttgctt 857641 acctttgtat ttgggagtat gctcagcggc aatgatgata aggtgcggct tgcaatcgtt 857701 gatcaggacg atacgattct ctcacagcat tatattcggc agctgaaggc acacgatgat 857761 atgtatgtat tcgaaaacat gtctgaaagc aaagcgtcag aaaagctgaa acaaaagaaa 857821 attgccggga tcatcgtcat ttcccgctcg ttccagacac agctggaaaa aggcaaacat 857881 cctgagctga ttttccgtca cggccctgag ctgtcggaag cgccgatggt caaacaatat 857941 gcagaaagcg cattggcaac gctcaatatt caggtgaccg cggcaaaaac ggcatctcag 858001 acagcgggag agaactggaa ggcggcgtat aaaacggttt tcgccaaaaa acatgaagat 858061 atagttccgg ctgtaacacg acagacgctc agtgataaaa aagagggtgc ggaagcaagt 858121 gacacagcct ccagagcagc agggttttcc atcctgtttg tcatgctgac catgatggga 858181 gcggctggaa ccattttaga agcaagaaaa aacggcgtat ggtccagatt gcttacagcc 858241 tctgtcagcc gagccgaaat cggtgctggg tatgtgctgt ccttctttgt cattggctgg 858301 attcaatttg gaatattgct tctttccacc cattggctgt ttggcatcaa ctgggggaat 858361 ccggctgcag ttattgtatt agtgtcactt tttctattga ccgttgtcgg cattggattg 858421 atgattgcgg ccaacgtcag aacgccagaa cagcagcttg cgttcggcaa cttgtttgtc 858481 atcgcaacat gtatggtgag cgggatgtat tggccgatcg acattgaacc gaaatttatg 858541 caatccatcg ctgaatttct tccgcaaaag tgggcgatga gcgggttgac agagattatc 858601 gctaacggtg cccgcgtcac agatattctc ggaatctgcg gcattttgct tgcatttgct 858661 gcgatcactt tcgcagcggg gctgaaagcg ctccgagcct aaaaaacatc tgccgtttag 858721 gcagatgttt ttttgcatgt gggtacattc gtatgggtgc agcctgaact gcggttaatc 858781 cttatctatc atagctaaaa ttgattccag ccaagaaacg taatttttct cccgctccag 858841 cgctttcgtt agcacaagat agtggccgaa gtccggtgaa gaaaatgaca tcggctctgc 858901 tgaagccata agcttttcat agcttccctg taagtcagaa agcttggcct ggcgtttttg 858961 cagctggtct ttgaacaaat cagaagcctc ctggcgcgat agacaagaaa tgaaataagc 859021 cttcagcata aattcatcct tcaccgtctc gggtatcggc tggtggcgga tcagccagtc 859081 atgcagctcc tgctttccgc tgtctgtcag ggtgtacatc tttttctcca gctttgtgcc 859141 ctgaatcgtt gtccggaacg tgataaatcc ttcatccgtc agctttttga gctcagggta 859201 aatctggctg tgcttggcgc tccaaaactg gccgagctcc tctttaaaat aactcgtaat 859261 atcgtatcca ctcaattcgc cttttcgcaa aagccctaat atggcgtatt ttaatactct 859321 catgctatcc tccgtgtctg gctgtttcgc aaaacagatg agccggtgct caactgtgat 859381 tctaactgcc tattcccctt attatagaaa agggaggaag ggaacacaac cgggctcttt 859441 ggaaatgaag ataaaaggtt tgtcagaagg tatccgattt atctccgtca atataaaaga 859501 gatttaaatt taattttcag aaaaaatagt aacgatattg attttttata tataatagga 859561 aattggtggt atgaaaattt tttgggggaa taaacgtgaa aaaagtactt atggcattca 859621 ttatttgttt atcgctgatt ctatctgttt tagccgctcc gccgtctggc gcaaaagctg 859681 agtcagtaca taatcctgtc gttcttgttc atggaataag tggtgcatca tacaactttt 859741 tcgctattaa aaactactta atttctcaag gctggcaaag caacaaactg tacgcaattg 859801 atttttatga taaaacagga aacaacctaa ataacggccc gcagcttgct tcatatgttg 859861 accgtgtttt aaaagagact ggggcaaaaa aagtagatat tgtggctcat agtatgggag 859921 gcgccaatac gctgtactat attaaatatt taggcggggg caataagatt caaaatgtcg 859981 taacgcttgg aggggctaat ggtttagtgt catcaaccgc gctgccgggc acagacccta 860041 atcaaaagat cctctataca tctatttaca gtctcaatga tcaaattgtc atcaatagct 860101 tgtctcggtt acaaggagcg cgaaacatcc agctttatgg catcggtcat attggcttgc 860161 tttctaatag ccaagtgaac ggctatatca aagaagggct gaatggcgga ggcctcaata 860221 caaattaata tcttcaaaaa acaacctgct gtctccgtta cagtgggttt tttcgtctga 860281 gaaagccata gggtcttatg accttagtct atcatgcata cgtcaattta tgacatcagg 860341 cactttttca aatagagcgg acatgttaag gtacaaccat cgatttctat caatttgaaa 860401 taaaaggagc gctgttatgc aaattaaaga aatttttatg atccgctgca tttcgtgctt 860461 aagtgtcgtc ttgctccata tcatttcaat ggtcctgatg cttcaggcag aagctcttgc 860521 agatatttct cacactgttg attctttccg cacactcctg atgttcagca cgcccgcttt 860581 tattttcatc tctgaatttt tactggcccg ttcttatcct gatggggtgc ctgacggttt 860641 tttaaagaag cggggaaaag tgatttttgt tcctttttta tttatcgcag ccatcgatgc 860701 gctgctgatg accagtgcga tggggggaga ggtaaccttt ctcgcgtttg tgcaaaaata 860761 tctggcgaac gtattcttag gaaactttat cggatacttc attctcgtca tctttcaatt 860821 ttacatgctg catatgatgt ttcatgagta tttgaaaaaa gcatcgccga aatgggtgct 860881 gtctatctca tttgtggtga cagccgctta tttaggctat ttctccgcag ccagcccggc 860941 tcctgcttct gaagagggag gggcatttcc gttcttctgg gttccgttcg caggctggct 861001 tttctacttt tgtctagcct actattgcgg aaaagaatac aagcgttttt tagcgctgct 861061 gaaccaatac cgctgggtgg tgtacggcgc cgcaattgct tctggggcgc tggttgtcac 861121 tgtttcttat gtcggtgaaa tcggcatgat cagctcgaag cggcctgata tcatgctgta 861181 ttcaacaagc atgattttcc tgtgttttca tttgttttcc aaaatgaagc atgtgccgaa 861241 aatcatgatg tttatcagca actattcctt ttcgatttat ctgcttcatg cctattttat 861301 gattataggc tacgtgttgc ttttgaatat gcccgaaatt cctgccgtac cggctgttct 861361 cctgttgttt gccgtgtgca cagccggccc gattatgacc tcatgggcgc tgaataagtt 861421 caaatacggg tatttatttg tggggaaaat ttatcagcca aaacagaaga aggtaacagt 861481 cgaagtgcgt gatcacgcag ggtgaaaaac aagcggcagg agggctcctg ccgcgtttct 861541 ttacttctca tccgcttgca gaactgtttt taaatatagt tttgcagact cagcaagtcc 861601 agatacatca gccttttctt catcgaaata cagggcgttt tgaatgatgc cgtcattcat 861661 attgaggaaa aacttggcga tagtcgcaag aggctgaacc ggctgaaact ctccctgatc 861721 gatccctttt tgcaatagcc ttgaaaacct ttccacaaaa agatcatacc ttttctccaa 861781 atactgccgc cgttcttcat tgcgccaagc tgtcactaaa tattcaaatt gcaccggcgc 861841 cagcgtatct gctacatctc gcaggccctc agtcagttca tccaaatagc tggaaatgga 861901 ggcccaaaca ctttggtgtt cagctgattt atcaagcttt cggagtcctt catccagccc 861961 tgtttcaata atgcggcgaa acatctcctc agtgcttgaa aaataaagat agacaccgcc 862021 ccggctgaaa cctgactctt ctacaacatc cttcatcgtc gttaattcga atccttttcg 862081 tttaaaaacc gttttggcag cctctaaaat ctctgcctgc cgtttatcct tgtgctcctt 862141 tgttactttt ggtgacaaga tatcgcctgc tttctgcaat tttcttacct ataagtgtaa 862201 tcaacccaat catgatcagc aagcagccac agacaagaaa agcaagtgat acaccgatcc 862261 attccgccag cacgcccccg cccgccatgc cgaggataga ggcgagggtt gtcgcactct 862321 gaatagcgcc gaacacccta ccgctgtaat cgacaggcac tgttgtttgc acgagaatct 862381 gaaatggaat atggacgagg ccgaaagccg cccccatgat gaaaaaagca aatataaaga 862441 gagtgatgcc ggcaattccc ataccgctta ggaatggcgc acctccagtt gctagtccaa 862501 gaagaagggt tccagctgag aaataaagca aataagaagt gattcgccgt ctgccggtaa 862561 tggccgctgt aaggagcatc ccggctccgc ttacggccat gcaccagcct gccagctcgg 862621 gcggagctcc tgaaaaggag cggataagaa taatcgcttg ggaatcacca atctgcaaaa 862681 caaagagaac gacacaagct gttagtaagc ctgttaatag aagcggcatc cgtttcaaaa 862741 actgaaggcc ttccttgata gaagtaagtg ctgctgtttt ttcttgaggt gtattggctt 862801 tttgtaaaaa agcatctctg ggaaggaaaa acaaaatgac agcggaaaga aagaaggcgc 862861 cggcgtttat ataaaaaaca gagtgtatcg agaaagcagc gatcagcgtg ccgccaaggg 862921 cagggccgaa gatttttgag ctgttatcaa tgatgctgct gacggaaacg gcctgctgaa 862981 tgtgtgcttc cggagccaat tccttaagct ttccgttttt agcaggtaaa aaaagtgaag 863041 aaaaacagct ctgaacggat agcaatacgt aaagctgcca aagctcactg acataaacgc 863101 agctgataac agtgagggca cggccgattt cagatagaaa catgatcgtt tttctgtcaa 863161 aacggtcggc aagcagaccc gatacaggtc cgagtacaat gacaggcaaa gcaaacgaca 863221 tcattaaaag cgacatatct aatggagaag catgaagctg aaaagcggct aatgttagca 863281 cggccaaaat gtgaagccag tctccaagtg aagaaatggt ttgcgaggct aacagtgtca 863341 tcagtccttt ttgattgcga aacaacggtt tttccatgat tcatcctcct gattattaaa 863401 atgacactag tgtcgttttt aattgtatgg gaaaaagaca caatatacaa tctttttctt 863461 gtaaaataaa ggagaagatt gaatagaagg gagaacattc atgacatcag tcaatctaag 863521 ctacccaata ggagaataca agccgaggga atccatatcg aaggagcaaa aagataaatg 863581 gattcaagta cttgaagaag tgccggcaaa attgaagcaa gctgtagagg tcatgacgga 863641 cagccagctt gacacaccgt accgggacgg tggatggacc gttcggcaag ttgttcatca 863701 tctggctgac agtcatatga acagctatat tcgttttaaa ttgagcttga cggaagagac 863761 accggctatc cgtccgtatg atgaaaaagc atggtcggag ctaaaagact cgaaaacggc 863821 agatccgagc ggctcactcg cgcttttgca ggagcttcac ggaagatgga cggctctgct 863881 ccgcaccctg acggatcagc aatttaagcg cggattttat caccctgata caaaggagat 863941 cattaccctg gagaacgcgc tcggcctgta tgtctggcac tcacatcacc atatcgctca 864001 tattacggag ctttccagac ggatggggtg gtcttaacgc ttttgccggc ggaaagccgg 864061 aatactgata gcagcaatca ccagaagtga gaccacagca gccgctgcat ataaatgatc 864121 atagccgctg gcgacactcg catgaatggc gtcgcttatc gcggttttga cttcaggaac 864181 gggaatgcgt tcgatttgtt cttgtaaaga agaaacttca gaactgtcga tctccggaat 864241 catctgcatc gccttttctg aatatccgct gtccgataag cggctgttga tctcatcacc 864301 tatttggtca aacccggctg tgataaaacc tgcataaaga gtaggcgcca aggtcagtcc 864361 aatttgcctt actaatgaaa gcgtgccaag agctgtaccc ttatttgttt ttgccgcttc 864421 tgatacaagg acgttcagcg gagcgcctaa cagaaagcca aaaccgatcc cagctgccac 864481 acttgcgatc acaaactccc atttttccgt gacccagagc ggaaataaag caaaccccgc 864541 acatgagatg attcccgaaa gaataacggt ttttacagga ccttttttgt cggtaagtgc 864601 tccgccaagc caagcgccga ttccggaagc caacgcaagc ggtgtcatcc aatagcctgc 864661 ttttgcggca gggacaccca aatactgttc gacatatgac gggataaaaa tgactgccgc 864721 caagagcccc ccggataaca aaccgatgat aagcgtgcgc tgaaacatat ggtttcgcag 864781 cagagaatac gccaaaatgg gatcgcctcc tcgcatttca actctctttt catacgagat 864841 aagcgctgca aaacagagta tgccaaaaat aatacatcca taaacctccg gattccccaa 864901 gctgtgtaag agatttgccc cgtcaagatt ggtcatgccg tacatcacag ctaaaatcga 864961 cagggacaaa aggaagattc cggccgcatc gaggcgctta gcctcaggtg cttttgtttc 865021 cgcgataaaa catgcgccga aaacaaccaa tagcacggca atcggcaaat taatcaaaaa 865081 tagccaatgc caagacccgg tccaatcaag cagaaagctt ccgatatttg gcccgagcac 865141 agcggccatc ccgttcattg cgccaagcag cccaagcgcc ttcccctgtt tttcctttgg 865201 aagggtcgcg agaatgtgag agctgccgat gatgaaaatc ccgccgcctc caagcgcctg 865261 aatcagccgc gatatcagaa agagcgggaa gctttggctc aaagcaacaa gcaaagaacc 865321 aagtccgaac aggcaaacct caatgagaaa gagttttttt ctgccgtagc ggtcggaaag 865381 ttttccgacg attggcacac tgacgctaag accgagcgta taaagggtaa tgccccatga 865441 tccccaggaa ggggaaacgg aaaacgactc gtttatcgtt gttaaagcag ccgaaataat 865501 tccgttatct aaagcagcca taaacacgcc aatcgtaaac aggctgattg cccacttttg 865561 gcttttctgc tctgttaatg cttcagacat tttcgtcaac tccttttagt tcacttgaaa 865621 tatattattc attttaaatg aactaaatgt caaataaaaa aagcctgctc ccgcagtttg 865681 cggatgacag acttactgat ttattctttt ttcgcattct ctaatgctct tgaaaggata 865741 gacagccctt cgtaaacagc ctgcttttct tcaggggaca gcagctctaa tgaacgcttc 865801 aatttcaggt ggcccttttc atacaaaccc cggaaaatct ttttcgcatt ctctgtcaac 865861 tgaacaacta cagagcggcg gtcctcttca gaatgtgagc gtttgacaaa tcctgatttt 865921 tcaagccggt caagcagccc agttgtattg gacagggaag cccccatttt ttcagcaatg 865981 tcgctcactt tcaatgttcc atggttgttt aatagcatca gcaccttcat ttgcggcatg 866041 ctcatatcca gtttcatcca ctcggacaca tcaccgagcc cggcggacgt taagactttc 866101 atatagagca cccatatttc ccgttcctcc gatgaaagaa tgttttcgtt taagactgtt 866161 gtatcgtgta aattatattc catttcatca cttcctcatc attcactcct cttaccatat 866221 tactcgattt tcactcctga aagaaagtga gcagaaaccg catgcgggac tttgtccgaa 866281 aaataacggt agtgtataat gagttggaga ttattggggg agaggatcga actagaatat 866341 gattggagag accattgctg attaaaaaga atgctttatc aatattaaaa atcgtttttc 866401 ctattgctgt tttgctattt gttatttatc aatcgaaaaa agaactgaca aatctgtcat 866461 tcaaacgtac gctcatggtc atcaacggac tggaacgaac ggatttattc atgcttgtgt 866521 tgatcggctt gctggctgtt gcggctatgt cgctgtatga ttacgtcctg aagtactcac 866581 tgcgcctatc gatcacaaac ggaaaagttt tcagggtttc ctggatcgcc aattcattta 866641 ataatgtgtt gggattcggc ggtttagccg gagtcgggtt aagaatgatg ttctataagg 866701 agcatacgaa agaccataag gcactcgtga aaggaatcgc ctggctcaca tcatctatgc 866761 tgctcggatt atctgttttc agcattttcg ttgctgcgag agtgctgcca gttgatgaag 866821 tgattcatga gaagccttgg ctgtgggcgg tcgttatcgg ttttgcactg atattgccgt 866881 tatctttagc ggtgtccaaa ataaaagacc gcaaagctgg ggacgaagag aatgcggata 866941 aagtgaaaaa tccgattttc gcatatattg gagcttcagt tgttgaatgg ctcatggccg 867001 ggaccgtcat ctattttgct ttgttcgcta tgggcattca tgcagatatc aggtatgtgt 867061 tcggggtgtt cgtcattgcg gcgatcggag gaatgatcag cctcgtgccg ggcggcttcg 867121 gctcgtttga ccttttattt ttgctgggga tggagcagct tggctatcat caagaggcca 867181 tcgttacttc tattgtgttg tacaggctcg cctactcatt tatcccattt atcttgggac 867241 tgttctttgc cgccggcgac ctgacggaaa atacaatgaa gcggctcgaa acgaacccgc 867301 gcatcgcacc ggcaattgag acgacaaacg ttctgcttgt tgttcagcgt gcggtattag 867361 tgagaatttt gcaaggctcg ctttccctta ttgtgttcgt agcaggtctg attgtcttgg 867421 cctcagtttc cttgccgatt gacaggctga cggttatacc gcacattccg cgcccggcgc 867481 ttttgctgtt caacggcctg tccttaagct cagcgctcat tctgctcatt ttgccgatcg 867541 agctttataa acggacaaaa cgttcctaca cgatggccat tacagcgctt gtcggcggct 867601 ttgtgttcag ctttttaaaa gggcttaaca tcagcgcgat attcgtactg ccgatgatta 867661 tcgtattgct tgtgctattg aaaaaacaat ttgtccgcga acaggcatcc tatacactgg 867721 gacaattgat attcgctgtg gcgctgttta ctgtggcgct ctttaactac aatctgatcg 867781 cgggctttat ttgggaccgg atgaagaagg tgctgcgtca cgaatatttc gtccacagca 867841 cctcgcatat tacacatgca accatcatgg cgatcatcat tgtgccgctg ttcttcttga 867901 tatttacagt ggtctatcat aagagaacga aaccgatcgg agagaaagct gaccctgagc 867961 gtcttgctgc gtttctcaat gaaaaaggcg gcaacgcgct gagccatctt ggttttcttg 868021 gagataagcg gttttatttt tctagcgatg gaaatgcact gcttctgttt gggaaaatcg 868081 ccagaaggct ggtcgtgctc ggcgatccat ctggccaaag agaatcattc ccgctcgtgc 868141 tggaagaatt tctgaacgaa gcgcatcaga agggattcag tgttttgttc tatcaaattg 868201 aacgagagga catggcgctg tatcacgatt ttggctacaa cttctttaaa ttgggtgagg 868261 aagcatatgt agatttaaat acatttacct tgactgggaa gaaaaaagcc ggccttcggg 868321 caatcaataa ccgctttgag cgggaggagt atactttcca tgtggatcat cccccatttt 868381 ctgatgcgtt tttggaggag ctgaagcaaa tctcagacga atggctcggc tcgaaaaaag 868441 agaagggatt ctcgctcgga ttttttgatc cttcctattt acagaaagcg ccgatcgcct 868501 atatgaaaaa tgcagaagga gagatcgttg cattcgcaaa tgtcatgccg atgtaccagg 868561 aaggagagat atcggtcgat ctgatgcgct atcgcggcga cgctccaaat ggcattatgg 868621 acgcattgtt tatccgtatg tttttatggg caaaggaaga gggctgtacg tcatttaata 868681 tggggatggc acccttggcc aatgtcggca ctgcctttac atccttctgg tccgaaaggt 868741 ttgccgctgt catttttaat aatgtcagat acatgtacag tttcagcggc ctaagagcct 868801 ttaaagaaaa atataaaccg gagtggcgag ggaaatactt agcgtatcgg aaaaacagat 868861 ctctttctgt caccatgttc ctcgttacac gtctgattgg caaaagcaaa aaagactccg 868921 tctaataaga cggagtcttt ttttatttcg tttttaagaa gtaggtttca atatcatcaa 868981 gcaggtagtt tgcggcttta attccgcctg cggttgtcca tacgacgtca tcgacttcat 869041 gtgcattacc tgacttcacg gccttcaggt ttttccatag tgaactgctt gtccactgat 869101 tggcccattt ttcattttct tttgcattat cggctttata agtgaaataa aacagcacat 869161 cagcatccat atcaggaata gattctttac tgtcggttga gaacgtaaat tggtcctttt 869221 gtttcttaaa cagttccact tgtttttcag ggcgtttgaa gccaagctgg tctaaaataa 869281 tcccaggaaa tgaatcggta taatagattc ttgattcacc ggataaaaag cgtacgactg 869341 aaacggtttt gtttgtctgg tcgcccagct tgttttttaa atcagaaaca cgtttatcaa 869401 aatcggcaat gacttccttg cctttgtccg ccttattcac cgcgttggcg tatagagtca 869461 ggttatcctt ccagttcccg gccaaagatt cagcaaaaac agtcggcgca atcgcattta 869521 actgatcata aattttttcc tggcgcactt tgtttccaat aatcaaatca ggctttaatt 869581 ctgcgatggc ttccacattc ggttccgttt caagaccgac gtttttaaca cctttcatgt 869641 catctttcag atagtcatac cacgggtcgc ccttccatga ctttacggct ccgaccggct 869701 taatgccaag cgctaagagc gcctctgttc cttcattagt taaaacaaca atccgttttg 869761 gattggcggg gatgttgtct gatgtcccca ttgcatgttt gaccgttctt gttttgctgc 869821 ttgacacctc gctgttgctt gaactttctg aactattaca ggcagaaagt accataacgg 869881 ccattaaaaa tacgaatagc atgctgatat gctttttcat ctttttcctc ccaatattga 869941 aattcattat catttagatc ataataagca gtgttaagag tgtcaatccc taattgagga 870001 ttattctcaa aaacaaacat tacatagtaa ataactagga gaattagatc atgatctgca 870061 aaaaggcatc ttcaaaatgg attgtgttag tatgtctgat tttcatttta ctgacggctg 870121 tctgcgcaag cgtcgtgtat ggctatacag gtacgtcatg gagacaggtc tatcaggcgt 870181 ttacttcctt caatggaaca aatgagcatg tcatcatcaa ggatgtcagg cttccgcgcg 870241 ctttggttgc gacagtcgtc ggcgcctcgc ttgcagccgc gggcgctctc atgcaggcgc 870301 tcacaaaaaa tccgcttgcg tcaccgggga ttttcgggat taacgccggt gcaggttttt 870361 ttattgttgc cggatcgttt tttctgcata ttcagtcacc tcaggcatta gtatggagct 870421 cgtttctggg ggcagcattt accgctgcga tcgtctatgc agcaggctcg cttgggaggg 870481 aagggctgac gccaatcaaa ctgacgctgg cgggagctgc catggcagcc atgttttctt 870541 ctctgacaca gggcttgctg tctgtcaacg aactcgagct tgcccaggtg cttttttggc 870601 tgactggctc tgtgcagggc cggagtctgg atctgttgat gacgatgttt ccatatgcag 870661 cggcagcgct ggtaatctgc ttctttctcg gccaaaaaat taatctcctc gttatgggag 870721 aagatgtggc aaaaggactc ggccaaaaaa caggcctgct gaaatttgtg atggcgcttt 870781 gtgttgtcat gcttgcaggg tccgctgtcg ccattgccgg gccgatttct tttatcggca 870841 tcattattcc gcattttgcc cgctttgtcg ttggtaatga ttatcgctgg gttctgccat 870901 tttccgctgt tttgggtgcc attttgcttg tttgcgcgga tatcggtgcg cgatatatca 870961 ttatgcctca ggaagttcct gtcggggtca tgaccgccat catcggaatg cctgtgtttg 871021 tgtacatcgc aagaaggggg gcgaagctat gaaacttcgt tttggcgtta ctgcggctga 871081 aaagaaagca tggatcgtct ttttggtttt actggggtta acagctgctg tactcatcat 871141 aagcgctggt ctcggacaaa ggtttattcc tccctgggat gtagcaaaaa cattctttgg 871201 tgcaggttcc aagctggatg aactgatgat catgtcgttc cgcatgccaa gaattttgac 871261 ggctttatgc gccggtgtct gcttggcagc ggcaggcgcg atattgcagg ggctcgtcag 871321 aaaccctctc gcatctccgg atattatcgg aataacagga ggagcggcgg tagcggtcgt 871381 gcttttaatg atgttcttct cagaccgcag cagttcactt acgatcagtc tgtcatggct 871441 tccagcagcc gcatttatcg gcgcatcggc tgtcgggctc atcgtctatt tactggcata 871501 caaaaatggc gcctccacat ttcggctggt gcttatcgga atcggatttt caatgtcggc 871561 gcaggcgatg actaccctgt tgatgatcaa aggcccgatt taccgagcat cacaagccaa 871621 tgtgtatatc actgggtcag tttatgggtc aaactggcag catgtaaaaa tagctattat 871681 cttatctgtc attctcttat tcatttgttt tgtcgcgcta aaaaatatga atatacaggt 871741 gctgggtgaa gatattgcgg cgggtgcagg aagcgctgtg cagcgaaatc gttttttctt 871801 gctccttttg agtacggctc ttactggttg tgcagtttca gttgccggca caatcggttt 871861 tgtcgggctg atggcgcccc atattgcaag acggcttgtc ggctcatctt atggcgcgct 871921 gctcccagcg tcggcactta ttggagctct gctcgtttta acagctgata tcgtcggcag 871981 aaccttattt gctccggtgg aagtgccggc cggcgtcttt acagcggcta tcggcgcacc 872041 ttattttatt tatttgctct ataaaacaag aaattcttaa tcgttacacc cattttctta 872101 aaaaagaaaa tgggtttttt tgataatgac tgaagattcg taattatttt tgctatactg 872161 acagagacat tgataaagaa agggcggcag atgaatgaaa gaagcagagg tattaaaata 872221 tgaagcattt acaagcagtc ccggcaaagg aaaccccgca ggcgtcgttt tgcagggaga 872281 cgattatacg gaagacgaga tgcagatcat agctgaacgt gccgggtatt cagaaacctc 872341 ctttatccga aaaagcgagt cggccgatct tgaactccgt tactttaccc ctggacacga 872401 aatgaatttg tgcggtcatg cgacagttgc ttctctttac gcattatgtg agaaaggaat 872461 gctggagagc ggtaaaacgt acagcatcca aacgaaagcg ggtatcctgc ctgtgaagat 872521 ttctgaaaaa gatggccgca ttcatatcac gcttgaacag gcctctccgc aattcaaacc 872581 atttacaggc gatcggaaaa aacttgcgga cgcactgggt atcaccgatg aagattttca 872641 tgaagacctt ccgattgtgt ttggcagcac tgggatatgg acagccatcg ttccgcttaa 872701 atcattggag gcttccaaaa aaatggtgcc agataacaaa caatttccgg aagtgttagt 872761 tgatctgcca aaagcttcag tccatccgtt tacctttgaa accgtccatc ccgacagcga 872821 cctgcacggg cgccactttt catccccgta ttcgggaacg attgaagacc ccgtgaccgg 872881 cacagcatcc ggcgtgatgg gggcttatat gaaacattat ggcaatgccg agcagcataa 872941 atttatcatt gaacaagggc aggaaattgg aaaagacgga aaagtggaga tcgaaatgaa 873001 cgaagccggc ggccatgtga aagtgaacat gacaggaaca gccgtttact cagaaacccg 873061 tattcttaaa atctaatacg gatgatggtt tacaaaaaga tgcactttcc gttatcatta 873121 tgaaatgata atcattttca attgcatagg aaggtgagac ggtatgcctc aaaccgaaca 873181 aatacatcag cattcagtac tgagggacat catacgcagc agaagatcga ttcgaaagtt 873241 taaacaagag ccagtacctt cagcagtcat tcttgacatg cttgaaacgg caaaatatgc 873301 gccaaatcac agagtgacag agccatggag atttatttac gtttccagtg agacaggtaa 873361 agcgaacctc attaatacat ttgcagcgtt ctctaagaaa tccaagccgg atatgacaga 873421 ggaaaagctt caaaatttca aaaacacact tgggcgcgtt ccgggatttc tcctcgtcgt 873481 gtttcaggaa gatgaaaacg aaagagcgcg ggacgacgat tttgcggcaa caagctcgtt 873541 gattcaaaat cttcagcttc tcgcttggga aaaaggaatc ggcatggttt ggaaaagcgg 873601 aaaaatcctt tatgacaaag aagtccatca ggcctttggt ttacaggata atgagcgttt 873661 cgccgccatc atacaaacag gttatcctga cgaggcgccg gaagtgaaaa aacgcacacc 873721 gatccgcgac cgattcactg aaatgtaaaa aaccccttgt ctcaaacgga gacaaggggt 873781 ttttcattaa cgagatttct ttttcgctct gttgtcggct gctttcgcac gctcttgcgc 873841 ttcgcggtca tctgcatcag caagctcggt tgaatattct tcgtaaacgc cgtcagtttc 873901 cctttttaag gcatcgggaa cttgtggaag cttttgtttg tttttatcac ggtttttgtg 873961 gatatgattt ctgcccatat caaattcccc ctaaaaagtg atatcaaaca aatatagtat 874021 ttggttttaa ggggctatgt attcctactt ccgcttagca gctttttccg cttttttaaa 874081 ttcgcctgaa taaagaactt cctgcatttt tttcaggttg gcgccttgct ggtgcttctc 874141 cctctttttt tccataaaaa ggacctcctt caaccatgtt attcttaagg ttgacgcttc 874201 ctgctgtttt tatacagtct ttcggtccgc tatcagctgt gagagtgcaa attcaagatc 874261 cgaatatgta aaacgaaatc cagaggttat cgcttttttc ggaagagcgc gctgtccttt 874321 cacaatcaaa agactcattt cacccaatgc ttttgataaa aagaattccg ggacggggag 874381 ccagtgcggg cggtgcttca cccgtgcaat cgtttttccg aattgcttca tgtccacagg 874441 attgggcgcg gtgacattca ttgggcctga gatgccggcg ttttccaccg catatcggat 874501 catctgggcc gcatcctcga catgaatcca tgacagccac tgccttcccg ttccgatcgt 874561 tccgccggcc agaaacttat aggggagaat catgagcggg agagcgcctt tttctccaag 874621 catcacgcca aatctcgcat aaactgtccg gatgcccatc gcttcaatat gctgtccttc 874681 cttttcccac aggtgtgcag tatggctgag aaaatcctca tctgacgttg cagaatcctc 874741 tgtgaaagtt ttctcaaggc ttgtgccgta aatgcccacg gcactggctt ggatcaatgt 874801 cttcggcttc tccttctgtt tctgaataag ccgctgcact tcacgcgtcg cattgatacg 874861 gctggagaga atgtgctgct tcgttttttc tgtccagcgg ccaaaaatcg attttcccgc 874921 aagatttatc cagacatcaa tatgaggaag ttcctgctcc ggtgcggctc cttccgacag 874981 ccattggaca tatgtcatat ttttttgttc agtttccctt gcgtttcttg ataaaatata 875041 aacatggtgt ccctggcggg taagaacgcc tgtcagatgc tggccgagaa aaccggttcc 875101 gcccgtcatt gcgatattca tgaacatctc tcctcatcgt tctaataaat atactttacc 875161 tcattgtaat aaaagaaaac gcgtttcagg cctgagaagg gagattaaga tgccgtttat 875221 tacaaaaata tcaacgcaaa aaaagaatac ggaacgcttc aatatttttc tggatgataa 875281 atacgccttc agcgtggacg cggatgtgct cgtgaaattt gagctcaaga agggaaaaga 875341 actcgatgat cttgacatca ttgagattca atacggcgat gaagtgaaga aaggcttcaa 875401 ccgtgcgctt gactttttat cctatcgaat gcggtcgacg aaagaggtcg aggatcactt 875461 aaagaaaaaa gaaacctcgc cccccgtcat tgcggaagtc atccataggc ttaacgatta 875521 caagtactta aacgaccagg aatttgccgc agcctatgtc agcactcaca aaaaaacaaa 875581 cggaaaaggc cctgatgttt tgttcagaga gctaagagcg aagggaattg atgacgatac 875641 aattaaggag gcgctaagtt ccttttcctt tgaagatcag acaagagaag cggtcaagca 875701 tgttgaaaag cttctcaaaa aagataaaaa gctttcgacg aaagaactca aacagcgcgc 875761 ccagctgcag cttcagcgca agggcttctc atttgatgtt atcagcgcgg cgatggatca 875821 gattgaatat gaaaatgatg aagacacaga gaaagaagcg ctgcgccttc acgcggaaaa 875881 agcgtttaga aaataccgct atgacggctc atatgaaagc gccatgaagg tcaaacaatt 875941 tttattccgc aaaggattct cactcgattt aatcgagcaa ttactgcagg aagaggagta 876001 ctgaaatgga gaaacgatac agtcaaatga caccgcatga actcaatacc gaaatcgcat 876061 tactttctga aaaagcaaga aaagccgaac agcatggaat cataaacgaa ctggcagtgc 876121 tcgaacggaa aattacgatg gcaaaagcat atttgctgaa cccggaagat tactcaccgg 876181 gagaaacata tcgtgtggaa aacactgagg acgagtttac catcagttat ttaaatggcg 876241 ttttcgcatg gggatacagg acctcttccc ctcagcaaga ggaagcgctg ccaatctcag 876301 tattgcaaga aaaagaataa agcgtaacag gaggctgatg atcagcctct ttttgtttgc 876361 agcacattta cacgaattct taaagaaaaa atcattgaat tcacttgaaa aatcttttaa 876421 gatgaaactc gttgtttttt aaaatcaaag gaggcgatga cgttgagtat caaaaaccca 876481 tctgtaaaat ttattatatt tgttcttatg atttgtacat tttcaatcgg ctatacagaa 876541 tacgcggtga tgggtatttt gacgtcgatt gccaatgact ttcatataca ggtttcatcc 876601 gcagggcttc ttgtcacggc ttatgcggca agcgtttgtt tgacagggcc gctcgtcacc 876661 atcatttccg tcaagcttcc gagaaagcct gtgcttcttg ggctgatggc gatatttatc 876721 ctttccaacc tgatgagcgc actggcgccg aattttgcgg tattggccat ttcaagaatt 876781 ttatctgcgt ccattcacgg cgctttcttc gcgattgcca tggtattcgc aagtgaaatg 876841 gttccgccgg aaaagcgtgc tgcagctgct gcttcaatga acggcggact gacagtggct 876901 ctaatgcttg gtgttccatt cggctcttat ctcggagatg tcctgaattg gagagcggtg 876961 ttttccatca ttacggcact tggtgtcatc ggatttttag gccttatggc tgccgtgccg 877021 aacagaaaac caaaagtgat cccaatgctt atgaatgagt ggggtgtttt taaacacaaa 877081 caagtgctgt tttccttcgc gattaccatt ttaggctatt ccggtgtctt tatcgcctac 877141 acctttatcg aacccatttt gaggcattca gccggattca gcacggttgg cattacaggt 877201 gctctctttg cgtatggatt gggaggcgtt gccgggaatt tctttgctgg aaaggtaccg 877261 ctgcctttgc tgactcggac gatgatcggc gtaatgatcg gtttaatcgg tgttctggct 877321 gtatttcctt acatcgccat ttacccggct gcagccattg tggcaacgtt cctattcggg 877381 gcatgcgcat tcggcacgcc gcctcttctg caaacaaagg tcatttcctc atctgagggc 877441 ggcacaacca ttgccgcagc tgtcagcgta tcagcattta accttgccaa tgcccttggt 877501 gcatggatcg gcggaatgat tttaaacgga acaggctctt attcctggct gtttgcagga 877561 ggtgcgctta tgaccgcatg cggacttgtg ctttctacct tcgcacactt atcagaaaag 877621 aagagcgtct acgaatatca agtcaataaa gggtaaaaaa cagctgcagt gtatgcagct 877681 gttcttcttt accgtttgcc tgaggctctc attctttctt gaggatgctg attgatagat 877741 ccgtcagcac gctttgaagc atagtcgtcc tttgctctcg gttcaccctg aaatttgttt 877801 tcgttttcgt aaggaaatcc tttttcttta tttcggacca tgtcatatcc ccctaggttc 877861 gagatcaaaa agttgcgtct tttcagatga agacgtaagg ttagtatatg gagaacacca 877921 cgtaataaag cgttattttt ttcctgaaga aaggagactg cacacatgaa tatgtacatt 877981 gagaaactga ctaatctgct tctggaaaag aacgagatga tcagctatat acaggcaaaa 878041 acgtgggtgg aattgttatg gagcgatttc gaagcaacct acgcaaaagc cggacacgcc 878101 tatcaaggtg aaaaaatgac tgaaaaaatc gtcacacaat ggattgaaaa ctatggcggc 878161 cagctccacc tttttcaaag ctcccgtaac gacgtgaatg attacttaaa tcaaagcaga 878221 ggccttttgc attaaaaacc tgccgttaac gaccggcagg ttttttcatt ttcttaaaat 878281 taccttaaca ggaagaaatc ataaacaaaa catgtttcac cagcctgtca atcagggaat 878341 accacttata tcttgtcaaa atgcgaggag gagctttata tgaaaaagaa acaagtaatg 878401 ctcgctttaa cagctgccgc aggactgggt ttgacagcac ttcattccgc tcccgcagca 878461 aaagctgcgc cccttcacga catatctgtc agcatgccat catccgatac ttacatcata 878521 aaagcaggaa agctgaatgt ccggactgag ccaaatcatg aaggtgatat tctcggcact 878581 gtatcatcag aacaaaaggt aaaagtcgat aggttcgtaa atgccgattg ggctcaaatt 878641 catttcaaag gaaagaaagc atatatttca actcactttt taatgaaaac cgcaagccaa 878701 gcgaaaacaa cgaaacagac agccttctat acaccgacgc ccgaaaacgg aaaagctaag 878761 cagctctcat ctggaacaga ggtgacaata cttgggtggg gattcagtga aaacggcgga 878821 tttgacttca cttgggcgtt cgtggattat ggcggagtta aaggctatat tcacacaaag 878881 gatttacaaa tgcgataaaa aggcaggccg aggcttgtct ttttgcctat gcatgaaaca 878941 tttcttcttt ctgcacgtaa caatgagaaa ggagatgatg atatgacggg tttagtcggc 879001 ggagggctta tgatcattgc gggcatactg atcaaactgt ttcctcccaa atcgatcaac 879061 agtgtgtacg gatacagaac gagacgctca atgtcagatc aaagattatg gaatgaagcg 879121 aaccgttaca gtgcatcatt aatgatcctg tcaggcttgg tgattgcggg aatgggtttg 879181 ctgctgggat caaacttgtt tattcttcag cttatcctgc tgattgccgc ctgtgtcata 879241 acatttatgc taacggagaa aaggctgaaa atcatgacgc acagtcaagg aggagataga 879301 agtggacgga gttaaatgcc agtttgtcaa tacgaacgga atcacgcttc acgttgcagc 879361 cgcaggacgg gaagatggcc cgttaattgt cctgctccat ggatttcctg agttttggta 879421 cggctggaaa aatcaaatca aaccgcttgt tgatgcgggt taccgggtca ttgctcctga 879481 tcagcggggc tacaatctca gtgacaaacc ggaaggaatt gattcgtatc ggattgatac 879541 attaagagat gatatcatcg ggcttattac gcaattcact gatgaaaaag caattgtcat 879601 cggtcatgac tggggaggag ctgtcgcatg gcatttggct tccacacgcc cggaatatct 879661 tgaaaaactg atcgcgatca atatcccgca cccgcacgtc atgaaaaccg taacgccgct 879721 ttatccgccg caatggctga aaagctcgta tatcgcatac ttccagctgc ccgatatacc 879781 ggaggcatca ctaagggaaa atgattatga tacattagac aaagcgattg gattatccga 879841 ccgtcccgcg ctttttacat ccgaggatgt cagcaggtac aaagaagcgt ggaagcagcc 879901 gggcgcgctg acagctatgc tgaactggta cagagccctc agaaaaggaa gcttggcaga 879961 gaaaccctct tacgaaacag taccttaccg aatgatctgg ggaatggaag accgcttttt 880021 gagcagaaag cttgcgaaag agacggaaag gcattgcccg aatggacatc tcatctttgt 880081 tgatgaagct tcccattgga ttaaccacga aaagccagcc atcgtcaatc agctgatttt 880141 ggaatatctt aagaaccaat aagctaaaat ttctctccat ccgtctgtca taatggcaga 880201 ctttttctgt gcgttttttt tcatagtctg ttttaaacat gacaaaataa cattaaaaat 880261 catgaatgtc accataaaat tgtaacaaaa aacaggttta aacgacttta aaaaaaggaa 880321 tagccttact gaagatttgt gtaaaactcc cctaaggcaa tacttaaaaa gaataataaa 880381 aagaaggtgc cttaatgaag caaggattaa tctcgattat tatcccgtct tacaatgaag 880441 ggtataatgt taaactcatt catgaatctt taaaaaagga atttaaaaac attcattatg 880501 actatgaaat attcttcata aacgacggaa gtgttgatga cacgcttcag cagatcaaag 880561 acttggcagc gacgtgcagc cgggtaaaat atatatcttt ttctcgaaac tttggaaaag 880621 aagccgcaat tttggcgggc tttgagcatg ttcagggcga ggcggttatt gtcatggatg 880681 ccgatctgca gcatccgaca tatttgctga aggaatttat caaaggctac gaagaagggt 880741 atgaccaagt cattgcccaa aggaacagaa aaggggacag ctttgtccgc tcactcttat 880801 catctatgta ttacaagttc attaataaag cggtggaagt cgatttgcgt gacggtgtcg 880861 gtgacttcag attgttaagc cgccaagctg tgaatgcact tttgaagctg agcgaaggaa 880921 accgcttctc aaaaggcctt ttttgctgga ttggctttga tcagaaaatt gtattttatg 880981 aaaatgtcga acgaaaaaac ggcacctcca aatggtcgtt cagcagtctg tttaactacg 881041 gaatggacgg cgtcgtttca tttaatcata agccgctgag attatgtttt tatacaggca 881101 ttttcatcct gctgctttcc atcatttata tcattgccac attcgttaaa attctgacta 881161 acggtatttc tgtgcctggg tatttcacca ttatctcagc agtgttattt ctcggcggag 881221 tacagctgtt aagtcttgga ataataggtg aatatatcgg ccgaatctat tatgaaacaa 881281 aaaaacgccc gcattatttg atcaaagagg cgaatatccc gaacaaagac ctgcctgaaa 881341 cgaacgaatt aaaaagcatg cggcgtctga caaaaatgca ctgaaaatac caagcgccat 881401 tggcagtgct ttttttgcgt gtctattatc ttaaaagcaa gactggagaa ttcatatgaa 881461 aagaaaacat atcatgatct atgcggccag tttgctggtg tccgttctgg cacacgcttt 881521 ttttgtgaaa gaatgggcgg aaggcaggta tatgacaggt ccgggtgacg ggcttgcgca 881581 aatgatcgta tttaaaaaat tattatttga ccaatataca cacgggaatt ttttctacaa 881641 ttattcattc ggacttggcg gcggcacatt cagtcagctc ggctattatt tttctgcgtc 881701 ttttcttttt cttgctgtgt ctgccgctgt ttggctgctt caagccgtcc agctgatcgg 881761 agaaacggat acgctttttt gggcagagtc agctgttttt atcagtattt tcaaattgag 881821 cttgatcatc tttacgtccg cttctgtttt tcattatctt cttaagcaca gggcggcatc 881881 gttcacggga gccgtgttat acggcgtctc aattatttat ttccgtcacg aagcgtattg 881941 ggaatttttc accgatacaa tggtttggct tccgctgctt gtgcttggcg cagaaaaaat 882001 tattagagag cggcgtccgg cgtggtttat cgttgcgtgt tcgctgacgt taatcaacaa 882061 tttttacttt gcatacataa accttatatt catcggaatc tatgtgctgt tcagatggct 882121 gatccgtttg gaaccacatg aagagaaaag atggattcaa atcagattat ttctcgtttc 882181 aggcttcatt tcttttggca tcagtgcggc ggcgtttgtg ccggtagtat acggtttttt 882241 aaacaacctg cgccctccat acagccagaa aatagagtgg ctcaatttcg atgataatat 882301 cttattttcg agccggatca tcattgtgcc ggccgctttt ctgctgtttt tgtttattat 882361 ttctttttac aaaaaccgtg tgtttcgtct ctttgccggg ttgagcctgc tgtttattct 882421 gtttcatttc agtccgtatg cggcaagcgt ctttaacggt ttttccgccc cgcaaaaccg 882481 gtttgaatat gttctggcct ttaccattgc gggagcagct gcggctggtt tgtcacagct 882541 gtctgaattg aaacggaaag aactgctccc ggccgcagct gtcgtcctgc ttctttactt 882601 gtatcatatc caaaggtata agctcgatat atggaagcct gcgaatgaaa gtattctatt 882661 gctcttactc atgacaatcg cagccttgtt tgctgcagct tttgcgaaaa aacgggcaaa 882721 aatggctgtg tacggtataa tcattctttc ttcgctgttt gtcgccaact cctatcaaaa 882781 atacgcgctc tcagaaggcg gcgatttgga cagtgtgaca aaagaatatc ttacaagtga 882841 ggaatacaga gggcgggaat catctgagct catcagacgt ttacagaagg aagacgatga 882901 cccgctcatg agaatcgact ggatgaacgg ggtccgcaat aatacgccaa tcatttacgg 882961 atttaatggc ttcagcgcgt attccagcat tttaaacaaa gatctgctgg ccttctattg 883021 gaatgattta agcatcgata tgggcaggga aagcgtcagc cgttacgcgt cattgggaga 883081 cagggcgaat ttatacagcc tgctttacgg caaatattat atgaccgaaa aaacaaacga 883141 agccagcgtc ccgtacggct tcaaaaagca tttagaaaca gagcattatg cagtttatga 883201 gaatcagtac atgcttccat tcgttaaaac agcggatgcc atatacagcg aaagtgagct 883261 ggaccgattg cccgctcttg cgaaagaaca ggcgatgctg aaaggaatta tattaaaaga 883321 tccatcagga aaaacggagc agacaccaaa accgtccaat ttgatcacca agtcggacat 883381 caccgcaaaa caagcccagt atcaaaacgg gctgctaacc gtaactggag aaaacggagg 883441 agagctgatc atcaccccga aacagccatc atccgctccg ggagactact atgtcagctt 883501 ttatttgaaa agcaaagcaa aagacaaagg atttacatta aaggtaaatg attatgtcac 883561 aacaaggaaa tcgaacaaat cgatctataa aaccggagta aataatataa cggtaagagt 883621 gcctaaatca ggccatatct caatcaatct tccgaaagga acctatgagc tgagaaacat 883681 agcgctctat gaagaaaatt accaaacgct gaaaaacgct gtaatgcaaa ataaaacaga 883741 gaaagcagac aaactgaatt ggaacaaaaa tcgactgacc ttttcctatc atctgtcaaa 883801 agaccagtac atcatgcttc cgatcccata tgaaaaaggc tgggagctga agatcaacgg 883861 aaaaacacag aagatcgaaa aagcggatta tgcttttata ggcttcaagg cgcaaaaggg 883921 agacaatcac attgagctga cttactatcc gccatacttc aaaatatcgg cgatcatatc 883981 tctcgtcagt ctgctgcttg ctgtttttta tataagacgt aaaaagcccg gctctatata 884041 gagccgagct ttaatttttt ctgaagtttt tcttcgctga atatccatcc cgtataggat 884101 gaacgaatcg tgagatcatg gccgatatga acaattgcga caaacggata atggcctttg 884161 ctccgataac gcaggtcgat aaatctcacc tcataatgat ctttaaacgt atccacttcc 884221 caccggtata ccggagaaaa ggacagaaac gccgcgatgt tatcatcctg ctttgccgca 884281 tgcattacat cggtttcagg aacaggcacc cgattaaatg tatccagaat cacgacatgt 884341 ccttccatgc ttcttcctac atagaaagca tgtgctgtcg tcactgcgat tcgccattgc 884401 ctgaatttca tcgttggaga aataataatg ctttcgatct catcatgaat catctcatga 884461 agcttccgtt taattctcag ctgcatgatc aggcgcacca agtagtagcc taccaatatg 884521 atatataagc tgagaaacgt gatgccggga ctcccgcctg cataccaaat cgcgatagct 884581 gccagatggc tgataaaaat aaacggatca aacgtattaa tcagcccgag cgcaacccat 884641 tttttcgaaa acggacgaat ggcttgtgtt ccataggcgt tgaatatatc aacaaagaca 884701 tgcagaacga ctgccagcag tgtccacagc cacaggtgca gaaaatcggc ctgaggataa 884761 aataaataca gaatcgccgg gatgatgaca gaccaaaaca aaacggcggg aattgaatgg 884821 gtaaatcctc tgtgattcct tatataaaca gcattgtttt taagctttaa cacagtatca 884881 atatccggag cctgagagcc cgcaagcgtt gcgatcataa cagcgtgagc cattgccgga 884941 tctgatccga caacaggatc aagcgtcgca ataccgccca gtgcgatgcc cataacgaca 885001 tgtgtgcccg tatccatagg tgacctcctt gcagggtgat cctgcacatt cactttgtaa 885061 gaaattcccc attttcatat acccaatttt taaactgatt caatcgttct catatgtttc 885121 cgctttttct ttattactat ttaatgtaac atattatcgt actgtgccct tagtgtacaa 885181 caaaaaacag tctaaagaaa agcggggcgc gaaagactgg ggagaaacac atatgaacgt 885241 acttgaagac aaattaaaac aaaaagacat acagcaattt cgcgatgatt taatctcatg 885301 gtttgaacga gagcagcgcg ttttgccgtg gagagaggac caagatccat ataaggtgtg 885361 ggtatctgaa gtgatgctgc agcaaacgag agtagagaca gtgattcctt actttctccg 885421 gtttgtagaa caattcccga cagtggaagc gctcgctgat gctgatgaag aaaaggtgct 885481 gaaagcatgg gaagggctcg gctattattc gcgagtcaga aacctgcaaa gcgcggtaaa 885541 agaagtgaaa caggaatacg gcggcattgt tcctccagac gagaaagatt ttggcgggtt 885601 aaaaggcgtc ggcccttata caaagggagc ggtgctcagc attgcctaca ataaacccat 885661 tcccgcggtt gacggaaatg tgatgcgtgt catgtccagg attctatcta tttgggatga 885721 tattgccaaa ccaaaaacaa gaacgatctt tgaagacgcc atacgagctt ttatttccaa 885781 agaaaaacca tctgaattta atcagggctt gatggagctt ggagccttga tctgtacgcc 885841 aaaatcaccc tcatgcctgc tttgcccggt tcagcagcat tgctcagcat ttgaagaagg 885901 cactgaacgg gagcttccgg taaaaagcaa aaagaaaaag cccgggatca aaaccatggc 885961 cgcgatcgta ctgactgatg aagacggaca agtgtatatc cacaaacggc cgtctaaagg 886021 tttgctcgcc aacctgtggg aattcccgaa tcttgaaaca caaaaaggga tcaaaactga 886081 gcgtgaacag ctcattgctt tcttagaaaa cgaatatggc atacaagctg atatcagtga 886141 tctgcaaggt gtagtcgagc atgttttcac ccacctggta tggaatattt cagtgttttt 886201 cggtaaagta aaacaagtgt cggataccag caagctgaaa aaagtaacga aagaagagct 886261 cgaacaattt gcgttcccgg tgtcacatca aaaaatctgg aagatggcag gagaagcagc 886321 cgccatctcg gctgctccgt aaaccattct taatcgtaag agacgcgcgt gccgtggctg 886381 tagtccgctt cattgcgctt cattccgccg cgcgcttcaa tttcttgcgt taattcccgg 886441 tattttgatt ggccttcttc gttcaaataa ggcataattt gctgaaaggc atgatgaaaa 886501 taagcgagtt cactgttctt ccaatctttt ttggaaacca tgttcaattc gctcatatca 886561 cgtccgacat acataacaga agaccccctt taaagttctt gccattattg tttgtggaaa 886621 taaaagaact atacgctaca aggagatgag gaaaaatgga acaaaataaa tgtgcactcg 886681 taacaggaag cagccgcggt gtcggaaaag cggccgcgat cagacttgct gagaacggct 886741 ataacatcgt cattaactat gcacgcagca aaaaagcagc attagaaaca gcggaagaaa 886801 tcgaaaagct tggcgttaaa gtgcttgtcg taaaagcaaa cgtaggacag cctgcaaaaa 886861 tcaaagaaat gtttcagcaa attgatgaaa cgttcggcag acttgatgtt tttgtcaata 886921 atgccgcttc aggagtacta agacctgtca tggaattaga agaaacacac tgggactgga 886981 cgatgaacat taatgcgaaa gcattgcttt tctgcgctca ggaagctgcc aagctaatgg 887041 agaagaacgg tggcgggcat attgtcagca ttagttcatt aggctctatc cgctatcttg 887101 aaaactacac cacggtcggt gtatcaaaag cagcgttaga ggctttaacc cgttatcttg 887161 ccgttgagct ttcaccaaaa caaattatcg tcaatgctgt ttcaggcgga gcgatcgaca 887221 cagatgcgct gaagcacttc ccgaatagag aagatctgct tgaggatgcg cgccaaaata 887281 cgccggcggg acgcatggtc gaaattaaag acatggttga tactgtggag tttctagtgt 887341 cttccaaggc tgacatgatc cgcggacaga caattatcgt tgacggcgga cgctcactgc 887401 tcgtttaaaa atttttaaaa aagaggaata gctatacgat cacctgcaca ttctaatgac 887461 cgtggaggtg ataacaatgg ctaactcaaa taacttcagc aaaacaaacg ctcaacaagt 887521 tagaaaacaa aaccaacaat cagctgctgg tcaaggtcaa tttggcactg aatttgctag 887581 cgaaacaaac gctcagcaag tcagaaaaca aaaccagcaa tcagctggac aacaaggtca 887641 attcggcact gaattcgcta gtgaaactga cgcacagcag gtaagacagc aaaaccaatc 887701 tgctgaacaa aacaaacaac aaaacagcta atcactgaaa cagaaaaaag cacttcatct 887761 tcgggtggaa gtgctttttt ctgtttgaaa aacgacaaaa cttgtggaag gtctacagaa 887821 tgagtcaaag ggtttgcttt atggagatcg aaatgattaa aggaggaaat gtttatactt 887881 tcatcaggct gaaggaggaa ccgatgaccg aatttgaaaa gctggtaagt gaacagatga 887941 aaacgatgga taagcttctc gatctccaat cagagctcga ccgctgcaaa caaattgagg 888001 cggaactccg gcatttggaa agggatgcaa ggctgcgtgg gattcaggct gaaattgcgg 888061 taaaacggaa acaccttgcc gatatacagg atatgtttca aaagcagaca gagcaggtca 888121 ttcgttcata tcgcagctca gaaaagccgt cttcctttgt gtagtgcagg aatgtgccat 888181 tccccggccg gaatggctct tttattttca tttttcaatt tgtaacgtta taataggtaa 888241 aagacgttgt cggtaagcaa atttggacat actaactgta gggctttata gaaagtaggg 888301 gagaaatatg ggctatccca aggaaggaga aaccattcaa attcacagct ataagcacaa 888361 cgggctgatt catagaattt ggaatgagac aacaatctta aaaagtacag aaatgtgtgt 888421 catcggagcc aatgaccgga cgatggtaac cgaatcagac ggccggacat ggataaccag 888481 agagcccgca atctgttatt ttcacgcaag acaatggttt aatgtcatcg ggatgctgag 888541 ggaagacggg gttcattatt attgcaacat cagttctccg tttgcctatg atggcgaagc 888601 aattaaatat attgattatg acttagatgt taaggttttt cctgacatga cctacaatat 888661 tctcgatgaa gacgaatatg atgatcatcg gaaagccatg aattatccaa aagaaatcga 888721 cagtatttta agagactact taaatacgct gctccattgg attcaccagc gtcagggacc 888781 gtttgcgccc gagtttgtcg atatgtggta tgaacggtat ttgcgctata caaaataatg 888841 gttacgtaaa aacctgttgc ggggtacaac aggtttttca catgggctca cacacatcat 888901 gataaagaga gagggggaat caaccgtggg ggttatgaaa cgctacatgc aattcgtcaa 888961 accttataag aagcaaattt tcgttacagt gttaatcggg atcgtaaaat tctccattcc 889021 gcttgctctc ccattgcttc tgaagtacgt agttgacgac attattcaag gaggcggcac 889081 ggccagtgac aaaaccacgt cattgttcac gattatggcg atcatgttcg ccttattttt 889141 aattttgcgc ccgcctgttg aatattaccg gcaatatttt gcccagtgga ctgccagcaa 889201 ggtgctttat gatataagag ctaagctgtt tgaccatata caaaaactga gccttcgttt 889261 ttacgcgaat acaagaacag gggaagtcat ttcccgagtg attaatgatg tagaacaaac 889321 aaaggatttc gtcatcacag ggctgatgaa tatatggctc gatatgctga cgattttgat 889381 tgtaatctct atcatgctca cactggacgt taaattaacg ctgatctcta tcgttttatt 889441 cccattatac ggaatatcag tgaagtattt ttacggccgt ttacgaaagc tgacaaggga 889501 gcgctcacag gctcttgctc aagtgcaggg gcatttgcat gaacgcattc aaggcatgcc 889561 tgtcatcaga agctttgcga tagaagatca tgaacaggct caatttaatg agaaaaacgg 889621 tcatttctta gataaagcca tccgccacac gaattggaac gcgaaaacct ttgcggtcgt 889681 taataccatt acagatttgg cgccgctcat cgtcatagcg tgcgccgggt attttgtcat 889741 taatggaccg ctgacagtcg gaacaatggt cgcgtttgtc ggatatattg acagaatgta 889801 caaccctgtt agaaggctga tcaattcctc tacaactttg acacagtcaa tcgcatcaat 889861 ggacagggtg tttgaattta ttgacgagcc ctatgaactc actgacaaac caaatgcgat 889921 aaaggccgat cagattcgcg gaggagtgga gtttcaaaac gtttcgtttc aatatgagaa 889981 ggacaaagaa aatattcttc atgatgtatc cttaaaagta aatagaggag aaactgtagc 890041 tctcgtcggc atgagcggag gaggaaaatc aacgctcgtc agcctgatcc caagatttta 890101 tgatgtaaca agcggcagac tgctgattga tgggacggat attcgcgatt atgaagcaag 890161 aagccttcgc aaccaggttg gtatggtgct tcaagatacc tttttattta gtgaaacgat 890221 tcgggaaaat atcgcgatcg gcaagcctga tgccacactt gaagagataa tcgaagccgc 890281 caaagctgca aatgcccatg aatttatcat gagttttcca gaaggatatg agacccgggt 890341 gggggaacga ggcgttaagc tttcaggcgg acaaaagcag cggatctcaa ttgcgcgggt 890401 attcctgaaa aatccgccgc tcctcatttt agatgaagct acatcagctc tggatttgga 890461 aagtgagcat tacattcaag aagcgatgga caaactggcg aaggatagaa caacttttgt 890521 tgtcgcccac cgtttatcga caatcaccca tgcggataag attgttgtca tggaaaacgg 890581 gacaatcatt gaaatcggaa cccatgatga actcatggac tatgagagcc aatacaagca 890641 cttatttacc attcaaaatt tgaactaaaa catcaatctt atatcctttt aacgaaggat 890701 ataagatttt tttgtatata aaaaaacccg gctgtttaac cgggttactc ttctgtttct 890761 atttcgcagt ctttcggatg atacgtttga aaacttgtga taagtgtttc taaatgttca 890821 agctgctcgc gatattccac ggcgcttgcc ataatattga gcatgttgta atcaataagc 890881 tcctcatccg tattctgctg attttttaaa aatgactttg ttaaaagctg cttataccgg 890941 atgccttctt caaccgcgtc atcatgcggc ttgatttttc cgacaaacct catcaaaatc 891001 cgctcgtgcc agtaaagcag gtaatcaagt tcttcagtca atgtttcctg aaactcttcc 891061 ggcatatgat agatctcgtt ttccagacga tgcagcttct tcaatgtatc aagcgcccga 891121 tttgcagtaa taatggcctg tctgaacagg acaagctttc ttgatttcac ataagtcgtt 891181 ttcttaaagt aacttctttc ttctttatat agaagatatg tctgatcaag cttgatcatt 891241 ttttctttca gtttttcaat atcctctttc aaaatcgaat gctctgtcga ctgccgcatg 891301 gacaatctga tccacttcat aatttcttcg gtgttttcga cggtattatg aatcagcttt 891361 gtttcgtact taggaggcaa aaacacaagg ttgacgataa aggaagaaag cacccctaag 891421 atgactgtgc ttgttctgat cagcgcgaac attaaaaagt cgtcaccggc agattctaat 891481 atcgcaatga ctgttacaag agcaattgaa attgtatgtt caattttaag tttcagcatg 891541 attgtaatga caataactgc tgttaacccg atcataatcg ggctgggtcc gaaaataagg 891601 ccgaacactg tggcaatcac agctccgatg atatttgctt gaacctggtc aataataatg 891661 agaaaagagc ggtaaatcga cggctggatc gcaaatatcg ctgcaattcc agcgaaaatc 891721 ggcgcgggaa gcccgatcca cgaagccaaa taaagggcaa gtgtaatcgc aatcccggtt 891781 ttgaaaatgc gggcaccaag tttcattggt ttgtgcgtgc attcctttct atagtaaatt 891841 gtgtgacata gcaaatgggc taatccttaa aattcccggt tagtttattt gctaaacaat 891901 taagtaatat acagggatcg atacaaatat tcaagctatt tttctagaaa aagaccaaaa 891961 tcttacacgc tgtttgattc cataaaaaaa caggagctca aagctcctgt tcaaggtatt 892021 tgattctagt tttttagatg tttaaatgca tcctcgaccg ctgtaagcgt gtctttaata 892081 tcctgctctg tatgtgctgt ggtaataaac caagcttcat acttagaagg tgctaaatta 892141 attccgcgtt ccagcatcag cttgaaaaac gtagagaatg tttctccgtc actccgttca 892201 gcctgctcgt aattttccac tttctcatca gagaagtata ccgtgagcgc accttttaac 892261 cggttgaccg taatggtgat gccgtgtgtt tctgcgtgct tcaaaatgcc ttcctcaagc 892321 atagcgccaa ggtgatcaag cttttcatac acgccttttt ctttgagcac ttccagacaa 892381 gcgatgcctg ataggatgga agcggggttc cctgccattg ttcctgcctg ataagcaggc 892441 cctagcggag ctacctgctc catgatttct tgtttgccgc cataggcccc aatcggaagt 892501 ccgccgccga taattttccc gagtgctgtt aaatctggtt tcacctgtaa gagatcctgc 892561 gcgccgccat acataaagcg gaaagccgta atgacttcat cgtaaataac gagagcccct 892621 gcattatgtg ttaattcatt tacttgttct aagaagccct ctttcggctc cacgataccg 892681 aagttgccga caatcggttc aacgagaacc gccgcgattt cactgcccca tttttcaaga 892741 gctgctttat agctatcgat atcattaaat ggtactgtga tcacttcgtt tgcaatgctt 892801 ttcggtacac cggctgagtc tggtgtgccg agagtagacg ggccggagcc tgcggcgaca 892861 agcacaaggt ccgaatgccc gtgatagcag cccgcaaatt taatgatttt tgtccggcct 892921 gtatatgcgc gagccacgcg gatggtcgtc ataacggctt ctgtacccga attgacgaat 892981 cttactttgt ccatagcggg aatggcttct ttgagcattt ttgcaaatgt aacctcgtgt 893041 ttcgttggtg ttccatacaa tacaccgttc tctgctgctt ttttaatcgc ttctgtaata 893101 tgcggatggg catgtcctgt aataatcgga ccgtacgccg ctaaataatc gatgtatttg 893161 ttgccgtcca catcccaaaa ataagcgccg cttgctttct ccattgcaac aggagaaccg 893221 ccgccgactg ctttatatga tctagacggg ctgtttacac cgccgacaat gtgctgtaat 893281 gcctcattgt gaagttcaat tgattttgta tgcaagaata aaaacctcct atatctccat 893341 gcgtcctttc tattgtagca tgcttccgaa caagaacaat ggcttcgggc ttcagattca 893401 gctgagatgg ttgtaatctg gacaagaatt ggatacgctt aataaaaaaa catccggagg 893461 taacgtaatg actatagaaa tcggacaaaa agcgcctgat cttgagttaa aaggtgatca 893521 tggggaaaca gtaaaattat cggattataa aggaaagtac atcgtgcttt atttttatcc 893581 aaaggacatg acaccgggat gtacaactga agcatgcgat tttcgggaca gtcacgaaag 893641 cttcgccgaa ctggatgccg tcattatcgg cgtcagcccg gacagccagg aaaaacacgg 893701 aaaatttaaa gagaagcata accttccatt tctgcttctt gttgatgacg agcataagct 893761 ggcggaagca tttgatgtgt ggaagctgaa gaaaaacttc ggaaaagagt atatgggaat 893821 cgagcgttcc acttttttaa ttgataaaga aggccggctc attaaagaat ggagaaaagt 893881 aaaagtaaag gaccatgtag ccgaagcgct tcaaaccctc aaagatatgt ctgaaaagta 893941 aatctctatg agcctatgct tacttttacc ctgatatcaa ttgacaaatt atcgtagaaa 894001 gagttacact aattataaac attacaatgt aagaattttt tttagaagag aggtgcatga 894061 cggatggctg cacatgaact aaaagaagcc ttagaaacgt tgaaggaaac cggagttcgc 894121 attactcctc aacgtcatgc gattctggaa tatctcgtta actctatggc tcatccaaca 894181 gcggacgata tatataaagc tctggaaggg aaatttccta acatgagcgt agcgacggta 894241 tataacaatt tgcgtgtgtt ccgggaatca ggtttggtaa aagagctcac atacggtgat 894301 gcttccagca gattcgattt tgtcacatcc gatcactatc acgcgatttg cgaaaactgc 894361 ggtaaaattg tggacttcca ctacccgggc cttgatgaag tggagcagct cgctgcccac 894421 gtcacgggct tcaaggtaag ccaccaccgt ttagaaattt acggcgtctg ccaagagtgt 894481 tcgaaaaaag aaaatcatta aaaataagct gaccgcacga aacggtcagc ttattttatt 894541 tcgacatttt ctttttatta taagactcat caaattcttt tccttctaat cccttatcta 894601 aagtcagcgg ctctcggcaa tgcatgcaca tatcgactac tcctaaaacc tttgtctctt 894661 tatcacagcc tggacaaatg acgcgaaccg ctttagtcga aagcattccg atccaaaagt 894721 aaactaccgt gctgagaccg atggataaaa gcccaagtat cataaacaaa ctagaaagca 894781 aaactgactc tttgaaaaag atcccgatgt acataatgat aaacccaacg aaaaccaaac 894841 ttaacgcaaa tgttctgatt ttattaattt tgctggagta tttcgccatg tccatccccc 894901 tctgttttaa ctatagcaca aacccgatgg gattttcttc atgttttcgg ttgaactgga 894961 atttacatat ggagagttac tgtgaaattg tttataatag ttcaatgtgt ttagaaaaaa 895021 ggaatttcgt tttaaccata gaattgaatc aaatagagaa taaaaaaatt tgaacaattg 895081 cattggagga atagtgatgg aaaatcttct ccgtccaatt taccaagaaa gagcaagtca 895141 ccccaataca ttggctgtca ttatgattga gagaagaaac aaaacatctt ccttaacaga 895201 taactttgat gcagctttgc tggtgattgt aaaggatgct gatgagccag tttttataaa 895261 gcattatgaa tttgatcatc aaacagcttc tttgcatgtg gtaacagatt ctcagattca 895321 agaatggatt ttgcttggaa caaatagaag aatcatagat tggattgtaa atggcagagt 895381 cttgtttgac cgtaatgaat acgtagttga actgattgac aggctgaata catttccgtt 895441 tgccgaacgt aaactgaaga tcggactcga atacggcaaa ttaatcagaa ggtatgttga 895501 agggaaagct ttttttgaag ccaatcaatt tttagatgcc tacaatgccg ttgttcatgc 895561 gctgcatcat ttagcacgta ttgaagtaat cgacagagga ttccatcccg aaaccacggt 895621 gtggagccaa gtgcgccaga tggagcccca agtgtacaaa ttatattccg agctgattga 895681 aagtcatgag agcctggaaa aaagacttga attattattc ttagcaaatg attttctcat 895741 ccattccaaa gccgagatcg gttcggcgca tcttttcgaa gtaatgaaag aaaaagacat 895801 ttggcaattc ggtgagcttc ttcaacatca tgacctaaag cactttaccc aagatcttgg 895861 cgttatgctt gattacttga cggaaaaggg acttatcaac gtctgccaga tagaaacgaa 895921 aggacaggct gtctatcacc gaggatattc ttttaaaaaa ggtgttgact ctgattcttg 895981 accgtgttat attattaaac gtcgctgatg cgcttctgag aaaacaagct cacagcggcg 896041 ggaaaataaa tcaaaaaaac atttgacaaa agaaagtcaa aatgttatat taataaagtc 896101 gcttcaacaa gaagtgaaaa tgatctttga aaactaaaca agacaaaacg tacctgttaa 896161 ttcagttttt aaaaaatcgc acagcgatgt gcgtagtcag tcaaactagg gcctgcacga 896221 cgcaggtcac acaggtgtcg ccgcaggatg cggtgaactt aacctgtgat ccatttatcg 896281 gagagtttga tcctggctca ggacgaacgc tggcggcgtg cctaatacat gcaagtcgag 896341 cggacagatg ggagcttgct ccctgatgtt agcggcggac gggtgagtaa cacgtgggta 896401 acctgcctgt aagactggga taactccggg aaaccggggc taataccgga tggttgtttg 896461 aaccgcatgg ttcaaacata aaaggtggct tcggctacca cttacagatg gacccgcggc 896521 gcattagcta gttggtgagg taacggctca ccaaggcaac gatgcgtagc cgacctgaga 896581 gggtgatcgg ccacactggg actgagacac ggcccagact cctacgggag gcagcagtag 896641 ggaatcttcc gcaatggacg aaagtctgac ggagcaacgc cgcgtgagtg atgaaggttt 896701 tcggatcgta aagctctgtt gttagggaag aacaagtacc gttcgaatag ggcggtacct 896761 tgacggtacc taaccagaaa gccacggcta actacgtgcc agcagccgcg gtaatacgta 896821 ggtggcaagc gttgtccgga attattgggc gtaaagggct cgcaggcggt ttcttaagtc 896881 tgatgtgaaa gcccccggct caaccgggga gggtcattgg aaactgggga acttgagtgc 896941 agaagaggag agtggaattc cacgtgtagc ggtgaaatgc gtagagatgt ggaggaacac 897001 cagtggcgaa ggcgactctc tggtctgtaa ctgacgctga ggagcgaaag cgtggggagc 897061 gaacaggatt agataccctg gtagtccacg ccgtaaacga tgagtgctaa gtgttagggg 897121 gtttccgccc cttagtgctg cagctaacgc attaagcact ccgcctgggg agtacggtcg 897181 caagactgaa actcaaagga attgacgggg gcccgcacaa gcggtggagc atgtggttta 897241 attcgaagca acgcgaagaa ccttaccagg tcttgacatc ctctgacaat cctagagata 897301 ggacgtcccc ttcgggggca gagtgacagg tggtgcatgg ttgtcgtcag ctcgtgtcgt 897361 gagatgttgg gttaagtccc gcaacgagcg caacccttga tcttagttgc cagcattcag 897421 ttgggcactc taaggtgact gccggtgaca aaccggagga aggtggggat gacgtcaaat 897481 catcatgccc cttatgacct gggctacaca cgtgctacaa tggacagaac aaagggcagc 897541 gaaaccgcga ggttaagcca atcccacaaa tctgttctca gttcggatcg cagtctgcaa 897601 ctcgactgcg tgaagctgga atcgctagta atcgcggatc agcatgccgc ggtgaatacg 897661 ttcccgggcc ttgtacacac cgcccgtcac accacgagag tttgtaacac ccgaagtcgg 897721 tgaggtaacc ttttaggagc cagccgccga aggtgggaca gatgattggg gtgaagtcgt 897781 aacaaggtag ccgtatcgga aggtgcggct ggatcacctc ctttctaagg atattatacg 897841 gaatataaga ccttgggtct tataaacaga acgttccctg tcttgtttag ttttgaagga 897901 tcattccttc gaaacgtgtt ctttgaaaac tagataacag tagacatcac attcaattag 897961 taatacaaga tatcacatag tgattctttt taacggttaa gttagaaagg gcgcacggtg 898021 gatgccttgg cactaggagc cgatgaagga cgggacgaac accgatatgc ttcggggagc 898081 tgtaagcaag ctttgatccg gagatttccg aatggggaaa cccaccactc gtaatggagt 898141 ggtatccata tctgaattca taggatatga gaaggcagac ccggggaact gaaacatcta 898201 agtacccgga ggaagagaaa gcaaatgcga ttccctgagt agcggcgagc gaaacgggat 898261 tagcccaaac caagaggctt gcctcttggg gttgtaggac actctgtacg gagttacaaa 898321 agaacgaggt agatgaagag gtctggaaag gcccgccata ggaggtaaca gccctgtagt 898381 caaaacttcg ttctctcctg agtggatcct gagtacggcg gaacacgtga aattccgtcg 898441 gaatccggga ggaccatctc ccaaggctaa atactcccta gtgaccgata gtgaaccagt 898501 accgtgaggg aaaggtgaaa agcaccccgg aaggggagtg aaagagatcc tgaaaccgtg 898561 tgcctacaag tagtcagagc ccgttaacgg gtgatggcgt gccttttgta gaatgaaccg 898621 gcgagttacg atcccgtgca aggttaagca gaagatgcgg agccgcagcg aaagcgagtc 898681 tgaatagggc gcatgagtac gtggtcgtag acccgaaacc aggtgatcta cccatgtcca 898741 gggtgaagtt caggtaacac tgaatggagg cccgaaccca cgcacgttga aaagtgcggg 898801 gatgaggtgt gggtaggggt gaaatgccaa tcgaacctgg agatagctgg ttctctccga 898861 aatagcttta gggctagcct caaggtaaga gtcttggagg tagagcactg attggactag 898921 gggcccctac cgggttaccg aattcagtca aactccgaat gccaatgact tatccttggg 898981 agtcagactg cgagtgataa gatccgtagt cgaaagggaa acagcccaga ccgccagcta 899041 aggtcccaaa gtatacgtta agtggaaaag gatgtggagt tgcttagaca accaggatgt 899101 tggcttagaa gcagccacca tttaaagagt gcgtaatagc tcactggtcg agtgactctg 899161 cgccgaaaat gtaccggggc taaacgtatc accgaagctg cggactgttc ttcgaacagt 899221 ggtaggagag cgttctaagg gctgtgaagc cagaccggaa ggactggtgg agcgcttaga 899281 agtgagaatg ccggtatgag tagcgaaaga ggggtgagaa tcccctccac cgaatgccta 899341 aggtttcctg aggaaggctc gtccgctcag ggttagtcgg gacctaagcc gaggccgaaa 899401 ggcgtaggcg atggacaaca ggttgatatt cctgtaccac ctcctcacca tttgagcaat 899461 ggggggacgc aggaggatag ggtaagcgcg gtattggata tccgcgtcca agcagttagg 899521 ctgggaaata ggcaaatccg tttcccataa ggctgagctg tgatggcgag cgaaatatag 899581 tagcgaagtt cctgattcca cactgccaag aaaagcctct agcgaggtga gaggtgcccg 899641 taccgcaaac cgacacaggt aggcgaggag agaatcctaa ggtgatcgag agaactctcg 899701 ttaaggaact cggcaaaatg accccgtaac ttcgggagaa ggggtgctct gttagggtgc 899761 aagcccgaga gagccgcagt gaataggccc aggcgactgt ttagcaaaaa cacaggtctc 899821 tgcgaagccg taaggcgaag tataggggct gacgcctgcc cggtgctgga aggttaagag 899881 gagcgcttag cgtaagcgaa ggtgcgaatt gaagccccag taaacggcgg ccgtaactat 899941 aacggtccta aggtagcgaa attccttgtc gggtaagttc cgacccgcac gaaaggcgca 900001 acgatctggg cactgtctca acgagagact cggtgaaatt atagtacctg tgaagatgca 900061 ggttacccgc gacaggacgg aaagaccccg tggagcttta ctgcagcctg atattgaatg 900121 ttggtacagc ttgtacagga taggtaggag ccttggaaac cggagcgcca gcttcggtgg 900181 aggcatcggt gggatactac cctggctgta ttgaccttct aacccgccgc ccttatcggg 900241 cggggagaca gtgtcaggtg ggcagtttga ctggggcggt cgcctcctaa aaggtaacgg 900301 aggcgcccaa aggttccctc agaatggttg gaaatcattc gcagagtgta aaggcacaag 900361 ggagcttgac tgcgagacct acaagtcgag cagggacgaa agtcgggctt agtgatccgg 900421 tggttccgca tggaagggcc atcgctcaac ggataaaagc taccccgggg ataacaggct 900481 tatctccccc aagagtccac atcgacgggg aggtttggca cctcgatgtc ggctcatcgc 900541 atcctggggc tgtagtcggt cccaagggtt gggctgttcg cccattaaag cggtacgcga 900601 gctgggttca gaacgtcgtg agacagttcg gtccctatcc gtcgcgggcg caggaaattt 900661 gagaggagct gtccttagta cgagaggacc gggatggacg caccgctggt gtaccagttg 900721 ttctgccaag ggcatcgctg ggtagctatg tgcggacggg ataagtgctg aaagcatcta 900781 agcatgaagc ccccctcaag atgagatttc ccattccgca aggaagtaag atccctgaaa 900841 gatgatcagg ttgataggtc tgaggtggaa gtgtggcgac acatggagct gacagatact 900901 aatcgatcga gggcttaacc atatttttga atgatgtcac acctgttatc tagttttgag 900961 agaataagtt tttcaaaaaa acacttgatt ttctcaagaa tacatagtat aatgttaaat 901021 gtcactgaaa ttgtctggtg atgatggcga agaggtcaca cccgttccca tgccgaacac 901081 ggaagttaag ctcttcagcg ccgatggtag tcgggggttt ccccctgtga gagtaggaca 901141 tcgccaggca gacttcattc cgcagtagct cagtggtaga gctatcggct gttaaccgat 901201 cggtcgtagg ttcgaatcct acctgcggag ccattattgg agagctgtcc gagtggtcga 901261 aggagcacga ttggaaatcg tgtaggcggt caactccgtc tcaagggttc gaatcccttg 901321 ctctccgcca ctgatactta tacataatta caattgaaag tctgggcccg ttggtcaagc 901381 ggttaagaca ccgccctttc acggcggtaa cacgggttcg aatcccgtac gggtcattat 901441 atgatggagg attagctcag ctgggagagc atctgcctta caagcagagg gtcggcggtt 901501 cgagcccgtc atcctccacc attatatcat cgcggggtgg agcagttcgg tagctcgtcg 901561 ggctcataac ccgaaggtcg caggttcaaa tcctgccccc gcaaccaaat tttaaaatgg 901621 tccggtagtt cagttggtta gaatgcctgc ctgtcacgca ggaggtcgcg ggttcgagtc 901681 ccgtccggac cgccatttga atacttaggc tcggtagctc agttggtaga gcaacggact 901741 gaaaatccgt gtgtcggcgg ttcgattccg tcccgagcca ccacctatgc cggtgtagct 901801 caattggtag agcaactgac ttgtaatcag taggttgggg gttcaagtcc tcttgccggc 901861 actgtttttt caaaatttaa tgtggagggg tagcgaagtg gctaaacgcg gcggactgta 901921 aatccgctcc ctcagggttc ggcagttcga atctgccccc ctccaccatt tataggggca 901981 tagtttaacg gtagaacaga ggtctccaaa acctccggtg tgggttcgat tcctactgcc 902041 cctgccaaat ttatgacatc ttgagattat ggcggttgtg gcgaagtggt taacgcacca 902101 gattgtggct ctggcactcg tgggttcgat tcccatcaat cgccccatat tatcattggg 902161 ctatagccaa gcggtaaggc aacggacttt gactccgtca tgcgttggtt cgaatccagc 902221 tagcccagtc tcacttttta tatcaactgc atataatgta ttaagtccat taaaaatgcg 902281 gaagtagttc agtggtagaa caccaccttg ccaaggtggg ggtcgcgggt tcgaatcccg 902341 tcttccgctc caattacggc ggcatagcca agtggtaagg cagaggtctg caaaaccttt 902401 atccccggtt cgaatccggg tgtcgccttc ttattgccgg ggtggtggaa ttggcagaca 902461 cacaggactt aaaatcctgc ggtaggtgac taccgtgccg gttcaagtcc ggccctcggc 902521 accaatttta cttacatggt aagttgaatt ggtgtttgtg ttttatcatt ataactaatc 902581 atattaatga tctacataag tagatcattt ttttaatgct ttgatttatc ataacaagtt 902641 aagttccgag gcctattata aagcggctgt atagctagtc tttcaacact tttattttat 902701 atttccataa aaactttttt gaaatacgtt gacactttat gagatccatg atatatttat 902761 attcgtcggt tagatacgac gtaaaacttg ccggtgtggc ggaattggca gacgcgcacg 902821 actcaaaatc gtgttccttc tggagtgtcg gttcgacccc gaccaccggt atactgaaaa 902881 acccgtttct taacagaaac gggtttttat tttttattaa agaaaaggag cctcggctcc 902941 tttttatact tactcagcgt attggtctag gatctcttct agcacctctt ctagctcttc 903001 tgtatcttca agctctgatt ggctgaaacg gacgcgtaca agctgttctc cgtcattata 903061 catctcttcc aaccaccctc ggagtcctct tgctctgcgg tcgacttcga aaatgatttc 903121 caaaccgtct tcgtctaaaa ggaaaatgag ctctaattca tcaagcatct gacgataata 903181 tccggaagtc ggaacgaatt cgaattcttg aacgaacgga agacgacgct ggaagtaggg 903241 cgcttgttcg cagtctgctt cgttaagacg gaagcccagg ttttcgattg cttcaagcac 903301 attttcaatc caagggtgcg cttcaacgaa aatgcggtca tgatcggatt tatcgatacc 903361 gccttgaatg tcaaggtctg tcaccacggc aacctctact ttccctacag tgatcggcgt 903421 atctagaggc agagtgaatg tgaacggaaa ttgatgctct tcaccaggct gtatggtaaa 903481 tgaaccagtg acccggaaag aatgaattgt agcgtatttc cggtgctctt catcgtcttt 903541 tacaatgaca taccgtgtgc taagctgtaa atcgatataa cggatgtcct gagcgatttt 903601 tccgcctttg acatgtaccg ttccctgtac ttcttctcct ggaaaatatg cgtctttttc 903661 taaaattgta tctacttttg cagctccaat tccggcactt gccgcaagct tcttaaaaaa 903721 tgacatgtta gatcttcccc tttttctttt ttctcaacag atatacgtaa gaaggaggaa 903781 aaaagattcg tttgattcat acttttttcc tattattcgt ctcggcctag ggacagacta 903841 agaataatat tgaaaataaa ggagtcgatg gaagtgaata aagaaagttt ggttgcagat 903901 gaattacaca gaatgttttt ggctggtgag ctgcaaatca cagtagagga ggatataaac 903961 aatatttccg aaaggctgag aaacggcgat ctcagtttag accgattaag cggtgaagac 904021 gtgtttataa aagaaacggt aaatgaggct ttaagaagag tggagcaata aaaaagagac 904081 ggcatctcat ctttgagatc ccgtctcttt ttgtggtctt tgctgtaaga taaaagcgaa 904141 tcgatttgga attgctcacc cgagccaccc cttttctaac agaagatctg acagttcatc 904201 atggagataa acagctgtat ctaattgatc atgcaatgct cttctgatgt ggggattttc 904261 ggttgctgtt gttgcgacag tgtatttgtt aatgctggtt tttattgttg ttaacaaatc 904321 aagaatatct ttgggacaaa gactttgttc aatgggaaac cacctccttt gtttttttag 904381 cagctcctga taagaaagta tttgactttg tttcttgctt ctatacaaaa tgctataata 904441 agcaacaaat tttgttgggg ggtgtgatga tgaagcagat tattgcgatg gggggcgggg 904501 gtttttcgat ggagccggat aatttgtccc tcgatcaata tatcctcaat caatcaaaac 904561 gagagcagcc tcgtatttgt tttttgccga cggcgagcgg agattcccaa aactatattc 904621 agcggtttta tcatgcattt caaacattgg attgcgtgcc gtctcattta tctttgttta 904681 agccaccatc atcagattta gtttcttttg ttatggaaat ggacgtgatt tatgttggcg 904741 ggggaaatac gcggaattta cttgtgttat ggaaagagtg ggggctggac catattctca 904801 gggaagcatg gaagaacggt gtggttgtag ctggaataag tgccggtgcg atctgctggt 904861 ttgaagaagg ggtgacagat tcagccggac cgctgacaag tttgaaaagt ttaggttttt 904921 tgcaagggag cttttgtccc cattatgacg gggaaaagga tcggagaccg gcataccacc 904981 agctgatatc taacaagttc ttatgcagtg gctatgcagc ggatgatggg gctgctctcc 905041 atttcataaa tgatcagctg tttcagactg tgagttcaag gtcgggtgca aaggcatatc 905101 gggtgatgat ggctgaacat gaaatagctg aaatcccgtt gccggtcaaa tatttagggt 905161 gaaattggct gaatattatc tatattcctc tttttttcag attgatttta tgataagatg 905221 agtgcgaaat caatagttac tgggggtgcc cgctttcggg ctgagagaga aggcaagctt 905281 cttaaccctt tggacctgat ctggttcgta ccagcgtggg gaagtagagg aattgttttt 905341 gttattgtct tgctgggcaa taatatgttt ctttctgact gtaaccgggt tcatttatat 905401 gaatccggtt ttttgtgctg gttatgggct tgattttgtc ctttcaaacg tagaaagggg 905461 aaggaaaagt aatgcaaaac aattcagtgc agcaagccaa catttccatt atgtcaagtt 905521 tttcaggcag caagaaggta tacgtggagg gttcttcttc ggacatccaa gtgccgatga 905581 gggagattgc attgagtccg acgacgggat cgttcggcga agaggaaaac gcgcctgtgc 905641 gtgtctatga tacaagcgga ccgtatacgg accctgaagt aaccattaat attcaagaag 905701 gattaaagcc gctccgccaa aaatggatca cagagcgcgg tgacgtggaa gagtatgaag 905761 gtcgggctat aaaaccagaa gataacggtt ataaaaaagc aaaaccaaac gtaagctatc 905821 caggattaaa gcggaaaccg ctgagggcga aggcaggtca aaatgtcaca caaatgcact 905881 atgcaaaaaa ggggatcatt acacctgaga tggaatttat cgccattcgt gagcatgtgt 905941 ctcctgaatt cgtcagagac gaggtagcca gcggccgggc gattattcct tcaaacatta 906001 atcaccctga aagtgagcca atgattatcg gccggaattt tcatgtgaag attaatgcaa 906061 atatcgggaa ttcagcggtt acgtcatcca ttgaagaaga agtggaaaaa atgacgtggg 906121 ccatccgctg gggagcggat acgatgatgg atctctctac cggaaaagat attcatacga 906181 cgcgtgaatg gattatccgc aattgccccg tgcctgtggg aactgttccg atttatcagg 906241 cgcttgaaaa agtaaacggc gtagctgagg atttaacgtg ggagatttat cgtgatacgc 906301 taatcgagca ggcagagcag ggagtggatt attttacgat tcacgcgggt gttttgctta 906361 ggtatgtacc gctgactgcc aaacggacaa ctggtatcgt gtcacgcggg ggagcgatta 906421 tggcgcagtg gtgtctggct catcatcaag aaagcttttt atacacacat tttgaagaaa 906481 tatgtgagat tatgaaaatg tatgatattg ctttctctct tggggatggt ttgcgtcccg 906541 gatcaattgc tgatgccaat gacgaagcgc agtttgctga attagagacg cttggagagc 906601 tgacgcaaat tgcctggaag catgatgttc aggtgatgat tgagggtcct ggacatgttc 906661 cgatgcataa aatcaaagag aacgtcgata aacaaatgga catttgtaaa gaagcgcctt 906721 tttacacatt ggggccgttg acaacggata ttgctccggg atatgaccat attacttcag 906781 cgatcggagc ggcgatgatc ggttggtacg ggacagcaat gctttgttat gtaacgccga 906841 aggagcattt ggggctgcca aaccgtgatg atgttcgtga aggagtcatt acatataaga 906901 tcgctgcgca cgctgcggac cttgcaaaag ggcatcccgg agcgcaaatc cgggatgatg 906961 cgttatcgaa agcccgtttt gaattccgct ggcgggatca gtttaattta tctcttgatc 907021 cggagagagc ccttgaatac catgatgaaa ccctgcctgc tgaaggagca aaaaccgctc 907081 acttttgttc catgtgcggt ccgaaatttt gcagcatgag aatttcacag gatattcggg 907141 attatgcgaa gaaaaacgat ctcagtgaag cagaagccat aaataaagga ttaaaagaaa 907201 aagcaaaaga gtttgtcgat acgggaagca atttatatca ataaaaaaaa tgaagatgga 907261 gaatgctcca tcttcatttt tttagaaaaa cagagagcgt cgaagcggag gaatactctg 907321 ttcaaagcgg aaaacatttt ctggatcata tgtcgttttg acacggcgga gtcgttcaac 907381 gttttcgccg taatatgttc ttggccagtt tctgatttcg atatctggcc aatttacgta 907441 gtctcccatc gtttctttcg aaagggacgt tctcagcccc tcaatccagc ggacattttg 907501 tcttttttct ccaggggatg tccagtttgt taagtattcc tgggcgatga ttgcgtcacg 907561 ataataaaat gccgtttggt cgggagcgac ccgtccggct gccccgccga gtgcttgctg 907621 ccagacactg gcgttttgat tcggagcgtg ctctaaaaag tgttttattg ttgagatcgc 907681 acgttctgat aatggctttt caatgaaaga gccggagcgt ttcatttttt gaggctgatt 907741 gcctcccggg ctgttaaaaa aggttaccgc ttcaatgaat ggcgttgttt ttaccattcc 907801 gcttgtcgga cttcctgctt tcaataaagg ctttaacagt ttttttaact ctgtttttgg 907861 cccgacaaat tggccgaggg cttctatgcg gtttacttct ttaggccaaa actctattga 907921 tgatgtaagc cggtcatctg tatacggggc ccagttctgc cacgtgttat atacttcctc 907981 aaaatcatcc catccccatg taatagaaaa aatcgacact tgagagatgg gcactgcttt 908041 aaatgtcatg gaggtgacta tgccgaaatt gcctcctccg cctccctgag acgcccaaaa 908101 taagtctgga tgatttgaac agctgactgt aatcagatca gcgccctctt tttcgtctgc 908161 tacgatcatc tcaagctgca cgaggctgtc gcaagtaaga ccggcagccc ttgttaaaag 908221 tccaattccc cctccgagag ttaaacctgt gagccctaca ttagcaatgg tgcctgcggg 908281 aagcgtcagg ccgtattgcc agagtgtccg atagacttct cccaattcag cccccgcttc 908341 aatataggcc agctttttat cctgattcac agttattttt ttcatctcgc ttaaatcaat 908401 aacaagaccg ttatttaaaa gggaaaagtt ctcatagctg tgtctgccgc ctctaatacg 908461 gaaaggcaca cggttttcac gcgcccattt cagcgcattg agtgcatcct gtttgttttg 908521 gcaaaacaca atgatgtcag gatacctttc taagcttagg ttaatattgg ttcttgcttc 908581 gttatagtcc ggatcatccc gtgtcacgat acgtccggtc aattttgtct tttccacact 908641 cccacatctc tttctctcgt attctagttt ctctagctta tgcgtcaggg gaaaagagtg 908701 tataaggaaa aagcggggat gcaatctgat acagtgtcaa caccctcaaa aaatagttga 908761 caggtcggta ttgtatgaat taacatggtc agtacaaatt tttcaaattt atcgcgctga 908821 tcggaacacc gaaggctctt atcgtttaga taagggcctt ttttgtatga aaaagggggg 908881 attattgatg ggagtcaaaa aagaaaaggg gagaaaacga ttcaggaagc gaaaaaccta 908941 cgggaatcag attttgccgc ttgagctgct gattgaaaaa aacaaacgag agattataaa 909001 cagcgcggaa ctcatggaag aaatttatat gaagattgat gagaagcata cgcaatgtgt 909061 aactaaatat aaaaaaaccc gctgactaca acgggttttt gcatttctcc attaagaatc 909121 ttttttaatc ggcaatccaa ggccttctgc cacgcgtttt ccgtattcag gatccgcttt 909181 gtagaagtgc tcgatttggc gcagcttgat ttcttctttt tctaccggct tcatggcatt 909241 aacgatattt tcaacaaggc gggtacgttc atcttcactc attaaacgat acagatcgcc 909301 ggcttgagtg tagtgatcgt agtgatcgta gcttacgctg tcagcgatac cttgtaccgg 909361 atatgctgct tgcttatcct caggtgactc ttttggaccg ccgaagctgt taggctcgta 909421 atacacagat ccgccgccgt tatcatcaaa acgcatttgc ccatcacgct gataattgtt 909481 tactttgttg cgtgcgcggt tgattggcag cgcttgatgg tttgcaccga cacggtagcg 909541 gtgtgcatca tgataagcaa aaagtcgacc ttgaagcatt ttatccggtg aaacatcaat 909601 accaggcacg agggttccag gtgaaaatgt cgcttgttct acctctgcaa agtagttttc 909661 cggatttctg tctagaacca tgcgtccgac ctcgattaac gggtagtctt tttgagacca 909721 aacttttgtg acatcaaacg gatcgaaacg gtacgtattt gcatcttcta aaggcatgat 909781 ttgcacatat agtttccatg caggataatc accgttttcg attgcgttga aaaggtcttc 909841 tgtatggtaa tcagggtttt caccggcaat ttttgctgcc gtattgacat caaggttttt 909901 cacgccttgt tctgttttaa agtgatattt aatccatacg ccttcgcctt cggcatttgt 909961 ccatttgaat gtatggcttc cgaagccgtg catgtggcga agtgtcgcag gaattccgcg 910021 gtcagacatc aggattgtca cttggtgcag tgactctggt gaaagtgacc agaaatccca 910081 tacagccgta gggtttttca ggtgtgtttt tggatctctt ttttgtgtat ggatgaaatc 910141 agggaactta atcgcatcgc ggataaagaa tacaggcgta ttgttgccga cgatgtcgta 910201 gtttccttct tcagtataaa atttaacagc aaatccgcgc gggtcgcgaa ctgtgtcagc 910261 agagccaagt tcaccggcaa ctgttgagaa acggatgaac aacggtgtgc gtttgccgac 910321 ttcagaaagg aaagcggctt tcgtgtattt tgttacgtcg tttgtcactt caaaatatcc 910381 gtgtgcgcct gctcctttgg cgtgaacaac acgttcagga acacgttctc ggttgaaatg 910441 ggccaatttt tcgagtaaat gtacatcttg aattaaagtt ggtccgcgag aaccggcagt 910501 cattgagttt tgattatctc caaccggagc gccccagcta gttgtcagtt tatttgaact 910561 catgttatca cctcttggaa tttataagaa cataatatca tctctaagta aaaagtcaat 910621 attattttat aattattata aaatagttat ctctattaat cgatatatag tatcgaaatt 910681 gttgaaaaac cttgttgtaa cagcttttta tgacacttaa taatttttgg agaaataatt 910741 tttccttctc tatttgcgaa acaagcagag taagtgataa acaaggatat caaaaatcgt 910801 atttaaaaaa gagttgacat atcggaataa tttgaattaa catgttattc aaacaaaaaa 910861 acaattgggc agctgatcgg accgccgaag gctctcatct ctacaagaac agagatgggg 910921 gcctttttgt tttttttgaa ggcggggttg gcagaaagag agggataaaa gtggctgtga 910981 ccatcagcat caaagaaaag gcatttgttc aagaaggccg caaaaacacg gtcttagaaa 911041 acatagaatt atcaatcgca ccaggcgaat ttctaacgct tatcggaccg agcgggtgcg 911101 gaaaaagcac cctgttaaag attattgcag ggcttgattc tgaatatgac gggagtgtgg 911161 aaattaacgg ccgcagcgta acagctccgg gtattcagca aggatttatt tttcaggaac 911221 accgcctctt tccttggctg actgttgagc agaatattgc agccgacttg aatttgaagg 911281 acccaaaagt caaacaaaag gtggatgaac tgatcgagat tgtcagattg aaaggatcgg 911341 aaaaagcata tccgcgcgag ctgtcaggcg gcatgtcaca aagagtagcc atcgcccggg 911401 ccctgctgcg ggagcctgag gtgctgcttt tagatgaacc gtttggtgca ctcgacgctt 911461 ttacaagaaa acacctgcag gacgtgctgc tggatatatg gaggaagaaa aaaacaacga 911521 tgattctcgt gactcatgat atagatgaat ctgtttattt aggaaatgag cttgcgatcc 911581 ttaaggccaa accggggaaa atccataagc tgatgcccat tcacctggcg tatccgcgaa 911641 accggacgac tccggatttc caagcgatca gacagagagt gctgtcggaa ttcgagaaaa 911701 cagaagattt ggagtacgca gaaggatcag ggatatagaa agggcggaag cggaaatgaa 911761 aaaaggactc attgtattgg ttgccgttat ttttctgctc gcaggctgtg gagcaaatgg 911821 agccagcggt gaccacaaac aattgaagga aattcgtatt ggtattcagc aaagcttaag 911881 cccccttttg attgcaaaag aaaaaggctg gttcgaagat gcatttgaaa aagaaggcat 911941 caaagtgaaa tgggtggagt ttcaaagcgg tccgccccaa tttgaaggcc ttgcggcaga 912001 caaacttgat ttttctcaag tcggtaattc gcctgtgatc gctggacagg cggcaggcat 912061 tgactttaaa gaaatcggtt tgtctcagga cggcttgaaa gcaaacggca tccttgtcaa 912121 tcaaaacagc ggcattcaag acgttaaggg cttaaagggg aagaaaattg cagtcgccaa 912181 aggcagcagc gggtttgatt ttttgtataa agcgcttgat caagtggggt tgtcagctaa 912241 cgatgtgaca attattcagc ttcagcctga tgaagcagct tccgcatttg aaaacggatc 912301 tgttgatgcc tggtccattt gggagccgta cttgtcctta gaaacaatga aacacggagc 912361 aaaaatcctt gtgaacggag aaagcacaga tttatattca ccgggtttta ctttagtaag 912421 aacaaagttt tcagaagagc atccagacga agtggtccgt tttctgaagg tgtttaataa 912481 agccgttgta tggcaaaagg aacatctgga tgaagcagcg gacttatatt ctgacattaa 912541 agatctcgat aaaaaggtcg tcgaaaatgt gctgaaaaat actgagccac ttaatgagat 912601 catcagtgac gacattgtga aagcacagca ggaaacagca gattttcaat ttcgaacaaa 912661 ggcgatagat aagaagattg atgtgaagga tgttgtcgat aacactttta tcaaaaaagc 912721 attagaggag cattcctcag gaggtgatca atgatgaaag cagaggctgc gggctcgctg 912781 cccaaaacga atgcggaagc ggtgcgaaaa aagcccggaa ggaagagata cggctggatg 912841 aaggggcttt tactgcccgc tgtcatcatt gccatctggc aggtcatcgg cgggctgggg 912901 gttgtgtccg ctacagtgct gcctacacct gttacgattg ttctgacctt taaggagctt 912961 attttgtccg gcgaactgtt cggccatctg caaatcagca tttatcgggc ggcacttggt 913021 tttttgcttg gcgcggggct tggattgatg atcgggattt tggccggatt ttccaaacgg 913081 acggagctgt atcttgatcc gtcgttgcaa atgcttagaa ccgtacctca tctggccgtc 913141 acgccgctgt ttattttatg gttcggattt gacgaagtat ctaaaatttt gctgattgcg 913201 ctcggtgcct tctttcctgt ctatatcaat acgtttaacg gcatccgcgg ggttgacgcg 913261 aagctgtttg aagtcgcccg ggtgcttgaa tttaaatggc atcagcagat atccaaagtg 913321 atattgccgg cagccctgcc caatatattg ctaggcattc gcttatcgct cggcattgca 913381 tggctcgggc tcgttgtggc agagctgatg ggctcaagct cgggagtcgg ctatatgatc 913441 atggatgcga gacagttttc acaaacgaat aaagtctttg cagggattat catttttgca 913501 gtggttggaa agctgacgga ttccttcgtc aggctgcttg aacgaaagct gttaaagtgg 913561 agaaacagct acgaaggata aaagatataa aggggagatg aatatggaaa ttctttggtt 913621 tataccgact catggagacg cgagatattt aggatctgaa agtgatggac ggactgcgga 913681 tcatctttac tttaaacaag tcgcgcaggc ggcagacagg ctgggatata caggagttct 913741 tctgccaacg ggaagatcgt gcgaggaccc gtggcttaca gcgtcggcac tggcaggaga 913801 aacaaaggac ttaaagtttt tagtcgcggt aagacctggt ttaatgcagc cttctctggc 913861 agccagaatg acatccaccc tagaccgcat ttcagacggc cggctgctga tcaacgttgt 913921 ggcagggggc gatccgtatg agctggcagg cgatggcctg tttatcagcc atgatgagcg 913981 ctacgaggca acagacgaat ttttaaccgt ttggcggaga cttttgcagg gagaaacggt 914041 ttcctatgaa ggaaagcata taaaagtgga aaacagcaat ctgcttttcc cgccgcagca 914101 agagccgcat ccgcccatct atttcggtgg ttcgtcacag gctggaattg aagctgccgc 914161 aaagcataca gacgtgtact tgacatgggg tgagccgcct gaacaagtaa aagaaaagat 914221 agaaagagtc aaaaagcaag cggcaaaaga agggagatcc gttcgatttg gcattaggct 914281 gcatgtcatt gcccgtgaaa ctgaacaaga ggcatgggaa gcggcagagc gcttgatcag 914341 ccacttggat gatgacacca ttgccaaagc gcaggcagct ttgagccgtt acgactcttc 914401 aggccagcag cggatggccg tccttcatca aggcgatcgg acgaagcttg aaatcagccc 914461 gaatctgtgg gcggggatcg gcctggtcag aggaggggca ggaacagctc ttgtcggtga 914521 tccgcagacg attgccgacc ggatagcgga gtaccaggca ctcggcatag aatcgtttat 914581 attctccggc tatccgcatt tagaagaagc gtattatttt gcagagcttg tatttccgct 914641 tttgccgttt gaaaatgatc ggacgagaaa gcttcagaac aaaaggggag aagcggtagg 914701 aaacacttat tttgtcaaag agaaaaatgc atgagtttaa ctaaaataca gccccccgaa 914761 catggtatga tattcaaaaa aagggggctt tttttctgaa aacattgaga agcgcggcag 914821 tcatttgcct catagctatg ctgtcagcat gcggacattc aaaacagatg gaaatcaaag 914881 cggcggacat atcagatctt gaaaaaaaca gaatggatgt cgcagcttca caggcattca 914941 ctgccgaagc cgtcaatatc ggtgaaggta tttcttcagc tgacatgtac atcgaacatt 915001 atcaaaaggg aaagcttgtt gagaggtttg gaccggttcg tgcagattat tcagaggaaa 915061 aaactgatac catacaattt gtttattttg agaatgaaga gggggaagga aagaataaac 915121 ataccaccat tcattttggc attgtggata aacagggaac tatagcggct gattcatcgg 915181 tgaaacgcga cgatagcaca acacaggaaa tgactcagaa tatttcatcg ccggaaccga 915241 ttactttcga gaagcctgct ttgatcggca gcagtattag agggactgac gagacaatgc 915301 acacctctga acataaaaaa gagctcatta agcatcaaga tgcgttactg tattatgtgg 915361 aattgcatca ttagaatggg cggcttcagg ccgtctgttt tacaaagcgg tatgcttgct 915421 tttttgaatg gtgaatgata cattttaaat cgtaacaatt tcgatttaaa gggaggctat 915481 gtgacttggc taaaaaatca aaagtggcaa aagagttaaa acgccaacag cttgttgagc 915541 aatacgctgg tattagacgc gagttgaagg aaaaaggaga ttacgaggca ctcagcaagc 915601 tgccaagaga ttcagcaccg ggaaggcttc acaaccgctg catggtaacg gggcgcccga 915661 gagcatatat gaggaagttt aaaatgtcca gaatcgcttt cagggagctg gcccataaag 915721 gccagattcc cggtgtgaaa aaagcaagct ggtaagaaaa aactccggcc gattacagcg 915781 cgccggagtt tttttcgttt ttcttgaaag agatgacgta ggaaaggtgc tggatgatca 915841 tgatgataaa cacaataata atagggaaaa acggaatgcg cgattgaaat agcggataaa 915901 aaatgagaag aaccgctgcg gcaggcagcg agaagtagac agcgatatat gacgcgcgac 915961 atgcttttgc cgtcatcatc tgctctcttt catcctgctc ttcaaactca tcaggcagaa 916021 gtagctgctt tctggcaggg cggctttttt tctgtaagta caaataaacc gcagacgccg 916081 caacaaacag aataaaggga gtgaggttta aatcaaatac catcccgccg ctctttgtgc 916141 cgaaaaaaga tgctatgcct tctgaggctt caaagtatga aatcagcgcc cagcatgcaa 916201 ggccaaataa aacaaggtga aaagctgctt ttgttttcat gctcatctta gttttcctcc 916261 tctaaccaaa agacatcctc cattttcatg gagaaggctt tgcagatttt cagtgctaac 916321 agcagtgagg gaacataatc gcctttttca atcgctgcca cagtctgtct tgtgacgccg 916381 accgtttctc cgagtttttc ctgagaatag ccgaagcgtg ccctcagctc ttttacttta 916441 tttttcatca tgacgtctgt ccccttcaca atctcgattg attatattgt atagtatact 916501 taacattatg taaatggaac ttaacaactt tacaaaaaga taactttttt tcgacaaaat 916561 ttttatattc ccttgacgaa aaataaataa acatgtaata taaaaaaagt cagagcggta 916621 ctgttgctga caatcacaaa tgcgggtgta gtttagtggt aaaacctcag ccttccaagc 916681 tgatgtcgtg agttcgattc tcatcacccg ctccatacat acgttattaa cgcagtgttt 916741 cgtttctcag ataaacgaag tattgcgttt ttttatgtga aaaagaacac ggtattcgtg 916801 ttcttttacg taagccaatg tactgtatgg gtgccgccgt gaatttgttc aaacattttc 916861 gttaatgatg ataagaggtt aacagcgctg cttttctcaa tcgatggcgg gaaaaaaatg 916921 atttgcagca tattcttagt ctcgtttgaa acgggatagt ggttgacgct gtttttgaaa 916981 tcgccaaaaa tgccgttttc atcagagaaa agcagtatgt tttctttttc tcccaatgag 917041 atccggaccg gctcatgaag ctttccggca tcataaatca taataggcag agaatatttt 917101 aatgcgaaaa aatcgattgt gtcatgggcc gagtctttac tttccatgaa ttgttccttg 917161 gatatcggga ccagcatgtc ctccattggg gttgtttctc cctcaaatga agggttaagc 917221 tgtttaaaga gtttctgcca ttccttgacg aaggattcat cggatatacc gccgtccgca 917281 tagtcgaaaa acaaggattc ttgaaacagg cggagtctgc ctttcagcat ttgcggtgag 917341 gagccgactt cgatattctc ataaatgaca gcagctgcat gtaagccggc cgcacgttca 917401 gtaataacag aatcaagttt gatattcact agcattcact ccagttacgt gatatcaacc 917461 tattataaac gctgtgtcgt tttatcacaa agaaaggagg ctgtgcaaaa catgaacgtt 917521 tatcagctca aagaagaatt aattgaatac gcgaaaagca ttggcgtaga caagattggt 917581 tttacgaccg ctgatacttt tgacagttta aaagaccgtt tgattcttca agaatcactc 917641 ggctatctct ccggctttga agagccagat atcgaaaaaa gggtgacgcc gaagcttctt 917701 ttgccgaaag cgaaatcaat agtggcaatt gctctcgcat atccttccag aatgaaggat 917761 gcgccgagaa gcacgagaac tgagcgcagg ggcatttttt gcagagcttc ctggggaaaa 917821 gactatcatg atgtgctgag ggaaaagctt gatctgctgg aggattttct aaaaagcaag 917881 catgaggata tcagaacgaa gtcaatggtt gatacaggtg aattgtctga tcgcgccgtt 917941 gcggaacgtg ccggaatcgg attcagtgcg aaaaactgta tgatcacaac acccgagtat 918001 ggctcttatg tgtatttggc ggaaatgatc acaaatatcc cttttgagcc tgatgtgccg 918061 attgaagata tgtgcgggtc ctgcacgaaa tgcttggacg cctgcccaac gggagcactg 918121 gttaatcccg ggcagcttaa tgcgcagcgc tgcatctctt ttctgaccca gacaaaagga 918181 tttttgcctg atgaattccg gacaaaaatc ggaaaccgcc tgtacgggtg cgatacgtgc 918241 caaacggtat gccctctcaa taaagggaag gattttcatc ttcatccgga aatggagcct 918301 gatcctgaga ttgccaaacc gttattgaag ccgcttttgg ccatcagcaa tcgggaattt 918361 aaggagaaat tcgggcatgt ctcaggttct tggcgcggaa aaaaaccgat tcagcgaaac 918421 gccattctcg cgcttgccca ttttaaggat gcttccgcac tgcctgaatt gacggaactg 918481 atgcacaagg atccgcgtcc tgtcatcagg gggacagccg catgggcaat cggaaaaatc 918541 ggagaccccg cctacgcgga agagcttgaa aaagcgctgg aaaaagagaa ggatgaagag 918601 gcaaagctgg aaattgaaaa aggaattgag ttgctaaaag cttcaggcat gactaaacaa 918661 ggcctgtcct gacatacgta tagagcagaa ggaaaaaaca cttgagatca tccaagtgtt 918721 ttttctctat aaaaaagtat ggcgggtggg gtgagcttga agtacatttt agaacaatta 918781 gcggaggagc ggctgggctt tctggttaac gggcatgcta tgagacagga gtctcaagtc 918841 ggagacctta aagtcatgga gcgtaagaaa aagcttctgg aaaaacgtaa agttgacatc 918901 ataaaagcga aagcaaaggc cgtgattaat catgtgcggg ttgaggatga cggaacgacc 918961 tgcctttcgt ataccatcca ttacgaatac gtgtgtaagg aacaagatga cagcttgtat 919021 atagaagagc acatagagga gcgaatggct ttcctgtatg atcacatttt gattagtgat 919081 caggaaattg cgaaaaagcc ggctggattt catgaaggga ccagtattat tgactattct 919141 gaagctgaag aggaaagaga agcgtttggc agggcttttc aatacgatcg tctcggcgct 919201 gtccaatatg ccgagaaatt ttggaacaag cgcaatcctg cttataaaaa tttcagcgat 919261 aactgtacaa attttatttc tcagtgtctt catgcaggag gcgcgccgat gcgcggtcat 919321 ccgaacaggg gatcaggctg gtggatgaaa caaagctcat ggagctacag ctggacggtg 919381 gctcactcta tgaaaatgta tttgtcgaat tcaaaggccg gactgcgtgc ggtgcgggtg 919441 aaatcagcgg aagaactgat gccgggcgat gtgatttgct atgacttcga aggagacggc 919501 cggtttaatc atacaacgat tgtcgtggca aaggacaaag gcaatatgcc gcttgtcaac 919561 gcccagactt atgacagcag gatgaggtat tggtcatatg aggattctac ggcatacacg 919621 ccgtcaatac gatatgcctt ttttcatatc gttgatgata cgacaaaaga gtaattaatg 919681 ttataatgat gggcggataa gaaaaacaga ggtgaacatt gtggcattac atgtcgtttt 919741 atatcaacca gaaattcccg ctaacacagg gaatattgca cgtacttgtg cagcaaccaa 919801 tacaacgcta cacctgattc gtccgctcgg cttttcaacg gatgataaaa tgctgaagcg 919861 tgccggactc gattattggg agtttgttaa cgttgtgtat catgattcgt tagaagaatt 919921 gtttgaggca tataaaaaag gcaagttttt ctttattaca aaatttggcc agcagcctca 919981 tacatcattt gattacactg atcttgacga ggattatttc ttcgtgttcg gaagagaaac 920041 aagcggtttg ccaaaggatt taattcaaaa taatatggac cgctgcctgc gtcttccgat 920101 gacagagcat gtcagatcgt taaatctgtc caatactgcc gcgattcttg tttatgaagc 920161 gctgcgccag caaaattacc gtgatttaaa atagtgaaaa acccgctcat cgatgatggg 920221 cgggtttttt tgcggatgtt gaaatgcttt gtttcgtttt tgggcttaac aacgtaacag 920281 tgttatgtta caatgtaccc atcaaaggag ctggacttat ggaagaacaa ttaatctcta 920341 aaaaagaatt acttgaaaga acatcgattt catacggtca gctgtatcga tggaagcgga 920401 aaaacttaat acctgaggaa tggtttattc gtaaatccac atttacaggg caagagacgt 920461 tttttccgag agaggagatt ttaaaacgta tatcaatgat tcaaaagatg aaagaaaatt 920521 tgtctttgga tgaaatgagg gaaatgctgt cgccgaaaat gaaggatgtc agcatgaccg 920581 ctgatgaatt gcttcataaa ggtttggttt caaggcctgc tcttgaagcc tattcagaag 920641 acggaggaag tccggttttt tcatccagcg atttgctttc gctgtttgtg cttgagggcc 920701 tgctgcagtc tggaaatgtc agccttgcag aagcaaaaat ggctgcagag gtattaaaga 920761 agcatgatac tgaagagatt gaaaaacaga cggagctgat tgtgctccgc aagctcggtg 920821 tcacaacttg ttttatagcg gctgcggcgg acagcatttt gtttgaatca tccgtaaagg 920881 ttgtggaacg ggtagattta ttaaaagctt cagaggaatt aaaaacaaca tttatgcagg 920941 agggccatca atggatgtag tggaaaagct ggtgataaat ggatcaggaa gttctaaggg 921001 aggaacattt caatcagttg agattaatgg cagcgggaca gtggccgggg acgtggagtg 921061 tgacactttt tcttttaatg gaaacggaaa agcggacggc agcgtcaaag cgaaagcggt 921121 aactatcagc ggttcaggaa agatacatgg agacgttgaa gcagaatcta tccggatgaa 921181 tggcactggt tttattcaag gagaggtatc tgcaaaacaa ttgaaaatcg ctggatcatc 921241 aacatttggc ggcactgtca aggctgatgg aattgacatt agcggaaaag ctgtcatgga 921301 agcagattgt gaaacagaaa cctttcaatc agaagggaaa tgcaaaatca gcgggctttt 921361 aaatgcagac caggtgatca ttaagctttc tgcaggggaa agctatgcgc gggagatcgg 921421 ctgccgccat cttcaagtga cctgcagaaa aggaatgctg acattgctca gattgatgcc 921481 gcagcctgtt ctaacagcag agctgatcga aggtgacgtg attgaattga caaatacaaa 921541 ggcgaaaacc gtgcgcggta ataaagtgat catcggcccg gattgccaga ttgaaaccgt 921601 cgaatacagc ggggactata cctgtgatcc aagcgcgtcg gttgaaacat ccacaaagtt 921661 gtaaggagga tcgtaatgga gacaacaaaa ctgggaaatt taaaattata tggcgctggg 921721 catgccgcag gaggcgcgta tcacaatgtc agcatcaaag gagaaggtat agttggagaa 921781 gggctgtctg ctgtaggctg ccgcatatac ggaacgggcc tttttctcgg aaaagcagag 921841 actgagcggc tgcgtgtgct cggagaaagt gaatgtaaag gcgatctgac agccggcaaa 921901 atcaatatat atgggacaat gaaagtcagc ggctcacttc aatttgatcg attcaatctg 921961 aaaggccaga ctgaaattgg cgggaatatg actggagaat cctgcgatgt gaaagggaag 922021 cttagcgtaa taggtgattg tgaaacagaa atgttccatg tcacaggctg tgttgatgta 922081 tcggggttat taaattcggg tgagatcaag ctgggattga gccatgatat aagccatgtg 922141 caggaaatcg gcggaacaac aattacagtg aaaagacgcg cgagtttttt tagccggaag 922201 aaagggaagc tgatcgccga tgtcatagaa ggagatcggg tttatttgga gaataccgaa 922261 gcggcagttg tcaggggaaa agaagtgatc atcgggccgg gatgcagcat cggaacgatt 922321 gagtacgaat acaaatgtga atgcgatccg cattcacaga ttaaagaaaa aacaaaactg 922381 taaaacattg ttctgttata caaaaagggt gctctttcag gagcaccctt ttttattctt 922441 ttccaggctt gctttcgtat cctgcggtaa aaattgatac taaaaaagtg acaatgacac 922501 ccatcatgat gattgttttc accgtctctc cccctcttca atttttccgt gctgtccgag 922561 tctggatgat tctgtatttt tctttattat gaacggtcgc agtctgcctt gtcaacgatg 922621 tatgagtatc tttattttta agaaaccaaa gcatgtatca cgagatggcg gcatagattg 922681 tatcaaagta ccttatttgc atagtgtatc aaacatgata gaggaggtcc ttatggatat 922741 attaaagaaa attgaaaagt acagagagga agagcagcgg ctgaaatggg aaggaacttt 922801 cgccgattat ttggagatta ttaaagaaaa tccgatggtc gcgcaatctg ctcattctcg 922861 agtttttaat atgataaaag acagcgggat agaggagatt gacggacgca agaagtacag 922921 tttttttgac cgcgagctgt tcgggcttga agaatctctg gagcgtcttg tggaagagta 922981 ttttcatccg gctgccaaac gtctagatgt cagaaagcgg attctattgc tgatggggcc 923041 tgtgagcggc ggtaaatcca cgctggtcac aatgcttaaa aaaggtctcg aagcgtacac 923101 gctgacagat aatggcgctg tatatgcgat taaaggctgc ccgatgcacg aggaccctct 923161 acatttaatc ccccatcatt tacgcgatga cttttacaga gaatacggca ttagaataga 923221 aggaagtctt tctcctttaa atgtcatgag gctggaggaa gagtacggag gaagaattga 923281 ggatgtgaag gtggagcgca tcttcttttc agaagataag cgtacgggaa ttggaacatt 923341 cagtccctct gatccgaaat ctcaggatat tgccgatttg acggggagta ttgatttctc 923401 aacaatcgcc gagtacggtt cagaatcaga tccgcgcgct tatcgatttg acggagagct 923461 gaataaagcg aaccgcggga tgatggagtt tcaggagatg ctgaaatgtg atgagaaatt 923521 tctctggcat ttgctttcct tgacacagga agggaatttt aaagctgggc ggtttgcgtt 923581 aatttctgct gatgagctga tcgtggctca cacgaatgaa acggagtatc gctcatttat 923641 ttctaataag aagaatgaag ccctgcactc aagaatcatc gtgatgccgg ttccttataa 923701 tttaaaagtg tctgaggaag agagaattta tgaaaaaatg attgcagaaa gcgatgtggc 923761 ggatgttcat attgccccgc atacgttgaa ggtcgccgcg atgttctcaa tccttacccg 923821 gttaaaagag ccgaagcggt cggatattga tctggtcaag aaaatgagac tgtatgatgg 923881 ggaaagtgtg gaaggatata actctgtcga cgttgaggat atgaaaaaag aatataatga 923941 tgaaggcatg agcggaattg atccgcggta cgtgatcaac cggatttctt caacgattat 924001 cagaaaaaat atggaatcga ttaattctct cgatgtcctt cgctccttaa aagaaggtct 924061 tgatcagcac ccatcaattt caagcgagga cagggagcgg tatttgaatt ttatctctgc 924121 cgcccgcaag gaatatgacg atattgcgaa aaaggaagtt caaaaagcgt ttgtttattc 924181 atatgaagaa tcagcaaaaa cacttatgga caattacctc gataacgtag aggcctattg 924241 caataaaaac aagcttcgtg atcctttgac aggagaggaa atgaaccctg acgaaaagct 924301 gatgagatcc atcgaagagc agatcggcat ttcggaaaac gccaaaaaag cgttccgcga 924361 agaaatttta atccgcatct cggcctatgc gagaaaaggc aagcggtttg attacaattc 924421 ccatgaaaga ctgcgtgaag ctattcagaa aaagctgttt gctgatctga aggatgtcgt 924481 taaaattacg acctcaacaa aaacgccgga tgagcagcag ctgaaaaagg taaatgaagt 924541 cgtggcccgt ttaattgatg agcacggcta caactcgacg agcgccaatg agctgctgaa 924601 atatgtcggc agcctgctga accgataagc aacgtgaccc gtccgaatag ggcgggttat 924661 tttgtcccat tttctaaata gtttgtcaat taaacgtgca tatgtgcata tgatgaatat 924721 aaatcttttc aaaagacttg tttcataatc tggcacaagc cggaatacgt atgtatcacg 924781 accacaaatg gttaaggagg ggaattcatg tcccaaaatg acagcggcca ttttttgatt 924841 tctgaggaaa actggtccct ccatcgcaaa ggcttcgatg accagcagcg ccaccagaaa 924901 aaagtgcagg aagcgatcaa aaacaatctt ccggacctcg taactgagga aagcattatt 924961 atgtctaatg gaaaagatgt agtgaagatc ccaatccgtt cacttgatga gtataaaatc 925021 cgttataact atgataaaaa taaacatgta gggcaaggag acggcgagag ccaggttgga 925081 gatgttgtgg cccgggatgg atcagacaaa aaacaagggc ctggaaaagg gcagggtgcc 925141 ggtgatcagg caggcgagga ttattatgaa gcggaagttt cattaatgga tttagaagaa 925201 gcgcttttta aagaattaga gcttccgaat ctccagcaaa aagagcggga caatatcatt 925261 catacagata tcgagtttaa tgatatccgt aaaacagggt taaccggtaa tattgataag 925321 aaaagaacga tgatgtcagc ctttaaacga aacgcaatgt caggaaaacc gtcgttctac 925381 ccaatttatc cggaggacct gaaatataag acgtggaatg acatcacaaa gcccgaatca 925441 aaagccgtcg ttttagccat gatggataca agcggcagta tgggggtttg ggaaaaatac 925501 atggccagaa gcttcttttt ctggatgacc cgttttttgc ggacaaaata cgagactgtg 925561 gaaattgaat ttattgccca tcatacagaa gcaagagtgg tctcggagga ggattttttc 925621 tcaaagggag aaagcggcgg aacaatttgt tcttccgtat atcggaagtc gcttgagctt 925681 attgatgaaa agtacaatcc cgcccgctat aacatttacc cgtttcattt ttctgacggt 925741 gacaacctga catctgataa cgcgcgctgt gtgaagctgg tcaatgatat tatgaagaag 925801 gccaatctgt tttgctacgg cgaggtcaat cagtacaaca ggcattcaac gttaatgtct 925861 gcatataaaa atgtaaaaga tgagaaattt aagtactata ttttaaaaca gaaatctgat 925921 gtttttcagg ctctaaagaa ctttttcaga aatgaagagt ctggtgtaag ccatcaattt 925981 tcgtaatgaa aagcccattt cagggctttt ttttatttaa taaaagcaag aaaacgcttg 926041 cgaaaaaaat acgggagaaa aagaaatttt tcctttgaca aatcttcttt catttattaa 926101 tattttatct tgtgaactat tattgaggaa tgaggtgaaa aggagttgac tgaatcagaa 926161 cgtgctttgc tcacttttga acagctcttc gatacgtctc gggcgatata taaaaaacag 926221 aagaagatat tggagattgt gcttgagcct tttgatatta cagtccttca atatttgctg 926281 atgtttaaaa ttcatcaaag cggaagcacc ccgctaagca agctggcaat gtcgcttgat 926341 cttaagcctg cttctgtgac gcggatgaca gatattctgt ataagcgcca attgatgaat 926401 cgatatgaca gtccggatga ccgccgtatc gtcatgattc agttaaccga agagggggaa 926461 gaactgatag aaaaagccgc tgtgcaatat gcaaaaatgg gtgctggctt gtaccaaaag 926521 cttgatacct cccagctgca gtatttgcgc aaactagccg gaagtttaac gaagcttgct 926581 gaaggctgtt cagaaaaaag cggtaattaa aaacttctca catattttca ccagctttcc 926641 gcaaaatgat agaggatgaa acgaaaggag aaaacaaaat gaacagagga cgtttaattc 926701 tgaccaacat tatcggtttg attgttgttc ttgcaattat agctggaggt gcttactact 926761 attatcaaag cacaaactac gtaaaaacag atgaagcaaa agtagcgggc gatatggctg 926821 ctattactgc tccagcagca ggtaaagtat ctgactggga tctggacgaa ggaaaaacag 926881 tgaaaaaagg cgacacagtt gcaaaaatca aaggtgaaca aactgttgac gtaaaatcca 926941 ttatggatgg cacaattgtg aaaaacgaag tgaaaaacgg acaaaccgta caagctggta 927001 caacaattgc acaaacgatt gacatggaca acctatacat cacagcaaat attaaagaaa 927061 cagatattgc ggatattgaa gtaggaaata gtgtagacgt agtagttgac ggagaccctg 927121 atactacatt tgacggtact gtagaagaaa ttggttatgc gactaactca acttttgata 927181 tgcttccttc tacaaattca agcggaaact acacaaaagt aacacaaaaa gttcctgtga 927241 aaatttcaat caaaaaccca tctgataagg tgcttcctgg aatgaatgca tctgttaaaa 927301 tttctgagta aaacagatca gtcatcaaac catgaaagga ggttgtctta gatggctaca 927361 ggcaaagaaa aaaatgcaaa aaaccctatg tcattgctga ttgtgctaat ggcgggttta 927421 tttttggcaa ttctaaacca aacactgctt aatgttgcaa tgccgcactt aatgactgaa 927481 tttggcgtaa gtgcaacgac gattcagtgg ctgacaacag gttacatgct tgttaacggt 927541 gtattgattc cgttatctgc tttcctgatt acacgatttg gccagcggag tctctttctc 927601 gtcgcgatgt tttgttttac gctcggtacg ttagtctgcg gtatcgcacc taacttctct 927661 acaatgctga tcggccgttt gattcaggcc gtgggcggag gtatcttgca gccgctcgtt 927721 atgacaacca ttctgttaat tttcccgcct gaaagcaggg ggaaaggaat ggggattttc 927781 gggctagcga tgatgtttgc tccagcggtc ggcccgactc tttccgggtg gattattgag 927841 cattatacat ggcgcattat gttttacgga cttgtgccga tcggcgcaat tgttatcatt 927901 gtggctttct tcatctttaa aaatatggtg gagccgcaaa aaatcaaact cgatactctt 927961 ggcgcaatcc tctcgattgt cggattcgcc tccttattat acggagtcag tgaagccgga 928021 tctgacggct ggaccgaccc gattgtattg tctacagtta ttatcggagc cattgcaatt 928081 gttgcttttg ttgttcagca attgcgtcat gatgatccga tgcttgattt cagagtgttt 928141 aaatatgaca ttttctcact ctcgagtgtc attaatatca ttattacagt ggcactttac 928201 actggtatgt tccttttacc gatttatctg caaaacctgg tcggctttac ggcgcttcaa 928261 tccggtctgc ttctgcttcc gggtgcgatc gttatgctga ttatgtcacc gatctcaggt 928321 attttgttcg ataaattcgg accgagaccg cttgcgatta tcgggcttct cgtgacagtg 928381 gtaacaacgt atcaatacac gcaattgaca attgatacac catatacaca catcatgctg 928441 atctattcaa ttcgtgcatt tggtatgtct ctcttaatga tgccagtcat gacagccggg 928501 atgaaccagc ttcctgcccg tctgaacagc cacggaacgg cgatgagtaa cacgcttcgc 928561 caaatcagcg gatcaatcgg aacaagttta attacgacga tttatacaaa ccggacgaca 928621 ttccattatt cacaaattgc agataaaaca agcacggcgg acccgaactt cctccatgcg 928681 ttccaaaatg cagtttcgaa tttaatggtg aatatgaatg tgtcttatga tacggcgaaa 928741 acatatgtgt actcacatat ttataaacac gcatcactcg attccaatgt catggggata 928801 aatgatgcct ttatgtgggc aaccttattc tgtgtagcag gtttgatttt aagtatcttc 928861 ctgcgtgacg tcagaaaaga taaattgcgt aagaagaaaa aagaggagct ttcattactt 928921 cctgctccaa aagaagctaa ggaatcttaa tctgtacagg gaggtttcct gaatgaaaat 928981 ttatgtagtg tatgatagtg aaggcgaaca tactaaagtg cttgcagaag cgattgctga 929041 aggcgcgaga gaaaacgacg cggctgaagt gttcatcgac catgtagatc aggctgatat 929101 ccgcaagctt aaagatatgg atgcgattat ttggggatgc ccagggcatt tcggaacaat 929161 cagctccggt cttaaaactt ggatcgacag acttggctac ttgtgggctg aaggcgagct 929221 gatcaacaaa gtcggtgctg tcttctgcac aacggcaaca acacacggcg gcttggaaat 929281 gacaatgcac aatttaatca cgccgatgtt ccaccaaggc atgattgttg tcggactgcc 929341 tggcaacgtg cctgaaaacg cactttatgg ctcttattac ggagcaggtg tcacttgtcc 929401 ggtagacagt gatgagttaa tgtctgagga aggtattcag cttggacgcg cgttgggaag 929461 acgtgtcagc caagtcacag gaaacctaac agcaggacag taaggagagg ttgaaatggc 929521 cattattata gcaataattg ctgctgtcat tgtcattgcg gcccttatta catttaacgt 929581 ccgcaacgcc tcacctggac ctgagaagca agaagcaacc gatagaatcg cacctccaga 929641 agaggaaaaa aacgaagcgc attaccctgc tgaagcaagg gctgccgagc atacgccatc 929701 cgttgtcaaa aacgattctc caaaagagaa gcgtgacaca atgggtgatg atatttacag 929761 gcaggcgctg caaaagttta agcattctga tgaagttcat gcagaagaag aggtcactga 929821 ggaaagtgac aaaatgcagg accgcagcta tcgtgatgcg ctgctctcta tgaaaaataa 929881 gaaaaagtaa tgaaaaaggc aaatccgttt actcatgcgg gtttgccttt tttgctgttt 929941 ccatcaatta tgtttttatc aaataaatcc atggaatatg ttgtattcca ccttgatcta 930001 gtgtactatg ttactcatac accgaggatt ttttccggga ggtaaagaca tgaattcttt 930061 tttaggttta ttaaagaaag atatcaagct ttcaagaatg tggctgctag tatggatatg 930121 cggaatcatt ttcttattgg gaacaggcca tattatagct tctcgcacga aagaacctct 930181 agtcattttt ggtttttttg ttgcagttgc tttttttctg cttttcttat ctcctgtttt 930241 tgttttttat caccttcgca aggaagggaa atcacagctt tggctgtaca atccaaatgg 930301 cggcttatgg ctgttttctt ctaaattggc agcatctttg ctctatcaat ttgtgattca 930361 gttggcatta acagcctatg gcatatggat gtatcatatg ctctctgtaa aaaatctgct 930421 ggagcatcaa gttgatataa cgagtacagt ggctttgctg aatatgtatg ggcttatttc 930481 ttcgttagat atgtcagtaa cagtcattgt gttttggact gtttttcact ctctcagaaa 930541 ttggcgcgga atgcggtggg ctgcgatggt tctgttggtc gcaatgtggt tattcttcga 930601 tgaatacatc ataagccctt tggttgaatc tcaaaagcat ttctggcctg taacagtcta 930661 ttgcaatttt gatttccact tccacaatgt ttggagattg gaactaaaac ctatccatct 930721 gtctgtgcta gggtttccta ttgctatagt catcacattc ttgctgctca tcatggcttc 930781 aaaactgctt gatcgtaaag tagaggtgta aatatggaca atcaattcca atcctcgaaa 930841 ccgatttatc tgcagatcgc tgatcagatc ttttataggc tggtcaggaa ggagctgctc 930901 ccaggagaca agcttccttc agtaagagaa atggcgattc aaactaaagt aaatcccaat 930961 acaattcaaa gaacttacag tgagatggaa aggctgggta ttgtggagac aagaagaggt 931021 caagggacgt ttattgcgga aaaagcagaa atcgtagacg agctgaaaga caagctgaca 931081 cgagaggtgc tggaaggctt tgtcaagcaa atgaaagagc tggggctaac gaaagaagaa 931141 atgttagaag ggattaaaac attcacagag ggaggctaaa atggaaatca agctagaaca 931201 tgtatcaaaa aaatacggcc gccatacggc cgtcaatgat gtgtcaatca ccctatcatc 931261 cggacggatt tatggcctga ttggaccgaa cggcagcggc aagtcaacga ccctgaaaat 931321 gatggctggc cttctgtttc cgacttcagg atttgtaaaa gttgatgaag agcaggttac 931381 gagagaaatg gtgcgtcaaa cggcttatct tactgagctt gatatgtttt atccgcattt 931441 cactgttaaa gatatggtga atttttatca gtcgcagttt cctgattttc atacagaaca 931501 ggtttataag ctattgaatg agatgcagct gaatccggaa aaaaagatca aaaagctatc 931561 aaaaggaaat cggggcaggc tgaaaatcgt tcttgcttta gcgagacggg cagacgtcat 931621 cttgcttgat gaaccttttt ccgggcttga tccgatggtc agggattcca tcgtaaacag 931681 ccttgtgtcg tacattgatt ttgagcagca gattgtcgtg atcgcgacac atgaaattga 931741 tgaaattgag actttgttag atgaagtaat catcctcgcc aatggagaaa aagttgcgca 931801 gcgtgaagta gaagatattc gtgaacagga aggcatgtct gttttgcaat ggtttaaatc 931861 aaaaatggaa gtttgctaga aagaggagga atatgatgaa aacagtgttg gaattgaaaa 931921 acgtgactaa aaacatcaga ggccgaacga tcattgatga tctcagtttt acgattcgtg 931981 aaggcgaggt attcggtttt ttaggaccaa acggagcggg gaaaacgaca accatccgga 932041 tgatggtggg gttaatgaag ctgtcgaaag gtgatgtcct catttgcggc caatcaatta 932101 cgaaagaata tgccaaggcg attaagcata tcggagcgat cgttgagaat cccgagctgt 932161 ataaattttt gagcggatat aaaaatctcc agcaattcgc aaggatggtc aagggtgtca 932221 cgaaggaaaa aattgatgaa gttgttgaac tggtcggttt aacagacaga atccacgaca 932281 aggtgaaaac atattctctg gggatgagac agcgtcttgg cttggcacaa tgccttctgc 932341 acgatccgaa agtgctgatt ttggatgaac cgacaaacgg ccttgatccg gcggggatca 932401 gagaaatcag agatcattta aagaagctga cccgagaaag aggaatggct gtcatcgttt 932461 caagccacct gctgtcagaa atggaactga tgtgtgatcg aattgcgatt ctgcaaaaag 932521 gaaagctgat cgatattcaa aatgtaaaag atgaaaacat tgatgagaat gatacatatt 932581 tcttccaggt tgagcagccg agtgaagccg ctactgtttt aaatcagtac gatttgctga 932641 gtaagacaaa tggtgtagaa atcaaactgg ctaaagagga agtccctgcg gttattgaat 932701 tgctggtgat gcagcaaatc cgtatttatg aggtcaaggt cataacaaaa tcattagagg 932761 accgtttctt agaaatgaca ggtgaaacaa aagaggaggt tcagcatgct taatttgatt 932821 tataatgagt ggctcaaaat tttcagccgt gccggaacat gggtgatgat cggaattctg 932881 gggctgacaa tggttggatt tgcatttttg gcgaatcatt tttctgccgg tgaatcaaat 932941 tcccattgga aacaagagct tcaagcacaa aacgccgaat taaagaaaga aatcaaagaa 933001 gatccttcac tgaaagatgg gtataaagaa acaatcacac tcaatgacta tcgcatcgag 933061 cataatatcc ctagtgacac gggctatacg gtatggtctt atgtaacgga ttcagcaaac 933121 tttaccatcc ttaccggtct gtttactatt atcatcgcgg ccggaattgt cgcgaacgaa 933181 tttaattggg gaacgattaa gctattaatg attcggccgc tcagtcgttt tcaaattttg 933241 atgtccaaat atattacagt tctcctgttt gggctcctgt tgctgttgat tttatttatc 933301 ggttctactt tattagggtt gatcttcttc ggaacgggtg gtgaaaccgc cgcgaatatt 933361 catttaatct ataaggatgg ccatgtcatt gagcaaaaca tgatggggca tttggctaca 933421 acgtatcttt ctgaatccgt ctcggcttta atggtggcga cgatggcgtt tatgctgtct 933481 gcggtattca gaaacagctc tcttgcggtt ggtttttcca tcttcttgtt ggttgccggt 933541 acgactgcaa ctgcatttat tgcagcgaaa tttgactggg caaagtatat attgtttgct 933601 aatgtcgact tgactcagta tgtggatggc acaccgttaa taaaagggat gactatgacg 933661 ttttctctcg tcatgctggc gatctacttt atcatcttcc tgttgcttgc tttcggaatc 933721 ttcatgaagc gggatattgc aaactaataa aaaaagctgt tttgcttatg caaaacagct 933781 tttttgtcaa aataaaaact gcaggtttgc acctgcagtt tttcatatca atttatgctt 933841 acgcttcttt agtaacgtta gcagcttgtg gtccgcggtt tccttcaacg atttcaaaag 933901 aaacagcttg gccttcttct aaagttttga agccttcgcc ttgaatagca gagaaatgaa 933961 cgaatacatc gtcttgacct tctacttcga tgaatccgaa acctttttca gagttgaacc 934021 attttacttt accttctaac atgaaatttc ctcctaaagc gatcataacg cttaaattca 934081 ctattcttgc tcttaacaaa ctttcaagac gaaaactctt acaaaacttt cttcttaaag 934141 atagttcgaa caaaaataat tacctttact ctaccagtaa tcttcagaaa aaacaactgc 934201 ttattgaaat ttttttcgga aaataccata tttatttttc aatttgatat ttatttacgg 934261 aaattcatct gttttctcga tatgtgatca tacgtttgcc ttagtattcc ttcattttgg 934321 gaagataagt aataggaatt gacaacctta ttggatatga gtaaggtaaa agttaatcaa 934381 tattacaaat gacaacgttt atcaactaag agagcgtatg atttttatgt ctgatattgc 934441 ttgcatgctc taatacatag ataggagtat ggtcacaatg aaaaagtggc ttatatgcag 934501 tttcgtcctt gttcttctcg tttcatttac tgcatgttca ccgtctgcag aacatgaatc 934561 gataaaaatc gggattgctg agtctgacgg ggcaatatgg aactatattg ctcaaaaggc 934621 tgaagaggca gggctggata ttcagctgat ccctttttct gattatgcgg agtctgatat 934681 cgcacttgct aacaaagaaa ttgatgccaa cgcctttcaa accatttcat attttcagtc 934741 gttcactgaa aaatacaaac ttaatttggc accgctcggg acgacataca taacgcccat 934801 gggcatttat tcaaaacgat atgaacgaat ccgagatata tcgcggggag ctgtcgtttc 934861 tgttccggat aaagcgttcg attttggcag ggcgcttacg gtgctccagg aagcgggttt 934921 gctaacgctg aaaaacggat ttaacggaac aggttcagtt gatatgatta aagataatcc 934981 gagacacctg aaattaaaag ctgtccggca acaggatgca gtgagcggtg ccgacgtgtt 935041 tgtcatgaaa ccatcagaag caaaaaaagc gggcttgaac ccgaaaaagc atacgctaaa 935101 gagcggcgga ctcatgtctg aggaagagat gaatttgatt gttgtcagag cggaggatca 935161 agatcgggaa gcgctgcaaa ccattcttga gctttatcaa gctgatgata cagcggcatt 935221 tatagaaaaa gaatatcagg gagatcttgt cccggctttt ctgcctttga aacgtctttc 935281 agattggaag aatgaattcg aacattgaat tcattctttt ttttctgaaa aacacactct 935341 gttccgtccc gtttctttcg ctttgtaaag catttgatcg gcaagaatgg gcaaggatcc 935401 tggctgttcc gtattattgg ggtaatgagc ggcccctagt gatatcgtaa ctgaaagctc 935461 gtcgccgttt gttaatacaa tcggtgcatc acttacagtg ctcctgatcc gttcagcgat 935521 ccgggctgct ttatcaagag aacagttcgg caggagcacg gcaaattctt caccgccgat 935581 ccgagcggca ggatcagtat ttcggatggt ctgcttcaga cgtaacccta gctctttgag 935641 cacctgatct ccttcatgat ggccatattg gtcattgatg gtcttaaaat gatcgatatc 935701 catataaatc agtgcaaatt gaaaatgcgg ggtatcggcc gcctgctgat acagagcttt 935761 tgtggtttct tcaaattttc ttcggttata cacgcctgtt aaaaagtcaa agtgcgcctg 935821 aaacttatat tgtttaaaaa gaagatgtgc atttgtttca tgatcaataa tatataaact 935881 gagcatgccg cccgctattg atatgatcca aaaatacaaa tgaagttcgt atgaatgtaa 935941 atctataaga aaataaaagg aaaaggagat caagctattt gtgattatta aaagatagaa 936001 agcatgtttt agttgaactt tttttcttct agaaacaatg agtgacggaa tggcagcgat 936061 acaaatgata ataaccgagt atagtgcaga tgtgttcatc gtaatcagca agcggcctgc 936121 agtgatcatg gccagggccg ttgccgttga aacccagcct ccataaagag cggcaatcat 936181 aatagggata tttcgaagat caataattga atgctgatag gtaaatccaa aaaccatcag 936241 aataaccccg agcaaaccgc aggccagtcc tttaacagct tgaaaggata tgctgtcttt 936301 tttatgtact agcctttctt taaacaggtg ggtgaagaga taattaaatg tgattaaaat 936361 ggtcaaattt acaaacagtt ctttcagcaa atattatcac ccttatataa ggtactaaag 936421 atggaaggga aagaaaagaa caaaaaaggc attatataag gtttttttac ttgaattgat 936481 aagttaaaat aattcgcact tgacccatcg gaattagtgt aatatagtaa atgagaaaat 936541 ttgaagggag agtttacctg ctttggagac tttactggtt gtattacatg tatttatttt 936601 atttttactt atcttagggc tctttgttat gcagaaaaaa catgtttcct tctctaaacg 936661 tgtatttact gcgctggggc tggggattgt attcggattt gcgcttcagc tgatttacgg 936721 cccgacttca aatatagtca ttcaaacagc cgactggttt aatattgccg ggggcggata 936781 tgtcaaattg cttcagatgg ttgtcatgcc gctcgtcttt atttcgattc tcggcgcctt 936841 tacaaagctg aagctgacaa aaaatcttgg gaaaatcagc ggtttgatta tcgggatttt 936901 agtagcaaca acagcagttg ctgcagctgt cggtatcgcg tccgcgcttt catttgatct 936961 gcaggcgatt caggttgacc aaggaagtac agagctttca cggggacagg agcttcagca 937021 gaaatcagag gatatgacag cgaaaacgct gccgcagcag attgttgaac tgctgcctgg 937081 aaacccgttt ttagatttta cgggagctag accgacttca acgatcgctg tcgttatttt 937141 tgccgctttc cttggagtgg cattcctcgg cgtaaaacac aaacagccgg aacaggcaga 937201 aacatttaaa aaactggttg atgccgttta tgccattgtc atgcgtgttg tcacactcat 937261 tttgagactg acgccttatg gggtgctggc catcatgaca aaaacaattg caacgagtga 937321 tcttgacagc attctaaaac tgggcatgtt cgtgattgca tcatatgccg cgttaatcac 937381 tatgtttatc attcatttgc tgctgctgac gttcagcggc ttgaatccgg tgatttattt 937441 gaaaaaagcg gtgcctgtac ttgtatttgc atttacgtca aggtctagcg caggtgcttt 937501 accgctgaat attaaaacac agagaagcat gggtgtaccg gagggaatcg caaactttgc 937561 cggttcgttc ggtctttcga tcggccaaaa tggatgtgcc ggcatttatc ctgcgatgct 937621 ggcgatgatg attgctccga ctgtcggcca aaatccattt gacccggtgt ttattatcac 937681 tgttatcgca gtcgttgcca tcagctcctt cggggttgcc ggagtcggcg gcggagcgac 937741 attcgcggcg cttcttgttt tatcatcatt aaacatgcct gtcgcgctcg ccggtttgtt 937801 aatctcaatt gaaccgttaa tcgacatggg gcgtactgct ttgaatgtca gcggaagcat 937861 gacatccggt cttattacaa gtaaggtcac aaaagaaatt gatcaagggg catttcatga 937921 tcaatccaga gtgattgaag ctgaagaagc gtaacatatg aaaacgtgta atccaagagg 937981 attacacgtt tttttaacgg ccaggctcta agtcctccag catttccatc atcgtgttgt 938041 cgtccatgac attcattgcg ttttgttcaa aatgaatggg ttcagcataa tgcggctgtc 938101 tttttttcgc ggctgtctca gtttgcctag tttgagactg tgtatgctga tgctgtggtt 938161 gctgctgtcc agcgtgctgg tgctgacggc cattttgccg ctggctttga tgctgcgaac 938221 ggtcctggtt atcaccgctg cttccgctgc ttccgctaaa tgcttgtttg accatgtttc 938281 ctacattaga agcatcaaac gtgttatttt ctgaatttcg tctgttcatt tgtcctgtga 938341 taaacccgct gattctttgg cggatctgag gtgataatgc agtaataagc atagttgatc 938401 ctatgatcaa tgctgcgggg ctgattcctc ttcgctggtt gaacaacatg atccctcctt 938461 tgcagtgtat tcatattttc cccctcgtta gacaaattaa ccgttatatt tcccgggaaa 938521 gcatttcctc cagatttgca tgcataatta aagccagtta gaaaaaccta taagtaaagt 938581 gataaaggag gaattcacat gtttggaaaa aaacaagtcc ttgcgtctgt gcttcttatc 938641 cctttgctta tgactggctg cggtgtagcc gaccaaggtg agggcagacg tgataataat 938701 gatgtaagaa acgtaaatta tcgaaatccg gccaatgacg atatgcggaa tgtaaacaat 938761 cgggataacg ttgacaacaa tgttaatgat aatgtcaata acaatcgtgt aaatgacgat 938821 aataacaacg accgaaaact tgaggttgct gatgaagcag ctgataaagt aacagaccta 938881 aaagaagtaa agcatgccga tatcattgtg gctggaaatc aagcctacgt tgcagtcgtt 938941 ttaaccaatg gaaataaagg tgcagtagaa aacaatctga agaaaaaaat agccaaaaag 939001 gtaagatcta ctgacaaaaa cattgataat gtttacgttt cagctaaccc tgattttgta 939061 gagcgtatgc aaggatatgg aaagcgtatt caaaatggtg acccaatcgc cggattattt 939121 gatgaattta cacaaactgt acagcgtgta ttccctaacg ctgaataaat gaaagaagcc 939181 gcacaatttg tgcggctttt tctttgcgtt aatgacacac tgcgaactca ggctgcatag 939241 agtaaaaata aaaaggtaca agacggaccg gctcagggag ggagacgttt gcgggatggc 939301 ataggaaagc gtgcggcatc cgctctattc ctgtgcggag tccttgtgat gctggctgta 939361 agctcagcca tcgtatcaag cgcgatgtat atcctgtctt ttccaggtca ggcatctgga 939421 ataacaaaag aacaagtgac gaagcacatg aagaaagagt cattcaaaca ggccgatatt 939481 tattacactt ctaaggaaaa gtccttactg ccattgacga aagaaacgct tgaatatgcg 939541 gtcagtatta atcagattat gattggatat tcgaatcaaa agcctattga cattattttt 939601 tttcctaatg aaaaacagat ggaggcttac tccggtttat tggatgtagt tggtttttat 939661 tctgaacggg agcagctgat cggattgttg cctgaagaga aaaagaaact gttagaaggg 939721 gacgaggtag cggtttattt gtaccagaga ttgttgattc atgaatactc gcaccatgcg 939781 tttcaccaga aattgaagga gcttgagacg gatcccgatg agtttccgtt atggtttcat 939841 gaagggttaa gcgagtggat tgcgaactat gaattgctca tagatccgat cacgttttct 939901 gtcgtgccct ttgaccgttt gcagactgat cgagactggc aggaagctag agccgaatat 939961 gacactgatg tctatttgca aagcttttat atgatcgatg agctgacgga caaatacggg 940021 aaagacatta tttcagaaat gattaaggaa acggcaaaaa aaggggactt tgaaaaaggg 940081 tttaaatcag caacaaagga aagtcttgat caatttgaaa aagattttaa gaaaaaattt 940141 gaaaaaaaca gtgcggcatt ggatagtatc tatccaatgc ctttgttatt agtgaagtcc 940201 ttgctgaccc attccgcctt gtgtcggagg catttgtcct tgggcagggg cgaatgaatt 940261 tcgcagctgt tccatatcct gcgcatcaag ctgaggaacc tggtaatagc cgtgtttgtt 940321 ttggtatagg aaaatttcaa atgccatttc aacatactcc tgaatttgcg cagacagtac 940381 gcgtcttacg gccggatttg tcatttccag agaagccatc gtcagcatag aagcttgtgc 940441 tttaatcgcg caaagcattt gtcggctgat gatgctgtca tcaatatcat tcatggattg 940501 aacaggtttt ttaggctgtg acggctgcat gccgtaaaca gtctggttgt cttccttcat 940561 catataagtt gctgtttttt gtgaaggttc gcttcctgtt ttgaagcatt ctgcagttat 940621 attgtattga gatgtgatga attgatgttg acgatcaagg atgtttagta attcttgatc 940681 cttacagaat tgtctcagca tcataaactg atcaagcaca gtaagtgttc cggaaagcac 940741 ctcatgcata tcaaacattt catgtccgcc gtggttttta tgcggtttgc caggaatacc 940801 tttgttcatt tgggattgct gctgctgatt gaactgatcc aaaccgaatt cctccttttt 940861 tttcagatca gctgtatttt gtgtcagtct gccgtgtatt atgcagaagc ctgaaaggaa 940921 ttatatgctg tctgtcgaaa tgataagcag acaaaatcgt tgtcattatg tgtataaggg 940981 aggaaatatg atgaggcgta ttctgcatat tgtgttgatc acggcattaa tgttcttaaa 941041 tgtaatgtac acgttcgaag ctgtaaaggc agctgaaccg caacagccta tatcgattga 941101 gaaggcaata cagcaaaaag aaggacaggc acttgtcgaa ggatatgcag tcggccaggc 941161 tgtttccccg cagcattata aactgacaag ccctttttca aatgattata atgttgcgct 941221 ggcagaccgt aaaaacaaaa catcgcccga acacatcctt cctgtgcaaa tcccctccgc 941281 cttcagaagc caatttgggc tgcaaaccaa tccgcttctt cttgggaaaa agataacggt 941341 tcaaggaaag cttgaaaatt actttaacac gacaggactt aaaaacgttc agtcgatgaa 941401 cgtaaccgat gacacaaaaa ctccgccggc tgaacagcaa gtgaccataa atgaagcacg 941461 gggaaggctg aatgaagaag taacgataaa agggatcatt acagctgatc aaaacgcaat 941521 cggaggcggg aagctgtcga cctttttgca agatgaaacc ggaggcatta acatttattc 941581 gccatcccct gaacaatttc ccgaattaaa agagggtatg gatgtcacgg tgacagggaa 941641 aatcacgtct taccaggggc tgaaagaaat cgttccaaac tcatcaggca tcaaaatcaa 941701 ccagtcaaat caatccctcc ccgcccccaa acacttaaca atcaatgaac ttattaacgg 941761 cagcctaggt gatcagtatg aaggacgcct tgtgaaacta accgcttttg tttcctcaat 941821 tccaagttct cctgccggcg gcggttacaa tgtaacaatg attgatgacg accatcatgc 941881 aatgacgctc cgggttatga atgaaacagg ggtgataaac gagcttgatg agggcaaatg 941941 gtatgaattt accggtgtgt taagcagata ccaaaccttt cagctgcttc cgcgaaaatc 942001 ggctgacctg aagctgcttg aagagcagcc cgcacctccg tctgcagagg gagaatatga 942061 agggattgtt gaccgggtag ttgacggcga taccattcat cttaaatctc cggtgcttgg 942121 aacgacaaaa atccggtttg taaatgtaga tgcacccgaa acatatcaca caccaaaaaa 942181 tgacgcagat gaaaatcaat taagatttgg caaaaaagca tctgactatc taaaaacggt 942241 tctgtccccg ggtgataaaa ttactgtcaa ggtcgggagt gaagccaagg acagctatgg 942301 cagattgctc ggacaagtca taaccgaatc aggttcaaac gtgaacttag agcttgtaaa 942361 aaacggctat gctccgacgt attttatttg gccggttgac aatgaagagg attatcagca 942421 atttcaggcc gcagtagccg ctgcaaaaaa agatcaaaaa ggaatttgga atgaaaacga 942481 tcccctcatg gaaatgccgt ttgaattcag agccagagag caagggaaag gcctgacaag 942541 atatgtgggg gactcgtcga ataaaacata tgtgcagcca gctgactgga agaagatagc 942601 tgtggaaaac agaattttct tcgcctcagc aagtgaagcg gagagcgcgg gatataaaaa 942661 aaggcaaacg gcacctcaag aacatgtgcc gcttagaatt ctcagcatga atgatttgca 942721 tggcaaaatc gatcagcaat atgagcttga tcttgatgga aatggaactg tagacggcac 942781 gtttggacgc atggattatg ccgccgcata tttaaaagaa aaaaaggctg aaaagaaaaa 942841 ctcgctgatt gtgcacgcgg gagatatgat cggcggaagc tctccagttt cctctcttct 942901 tcaggatgaa ccgactgtag aactgatgga ggacatcgga tttgatgtcg gaaccgtggg 942961 aaaccacgaa tttgatgaag gcacggatga acttctgagg atcttaaatg gcggtgatca 943021 tccgaaaggc acaagcggat atgatggaca gaactttccc cttgtatgtg ccaattgtaa 943081 aatgaaatca actggagagc cctttttgcc ggcttacgac atcattaatg tggagggcgt 943141 acccgttgct tttatcggag ttgtcacaca gtcggcagct ggcatggtta tgcctgaagg 943201 aataaaaaat atcgagttta cagatgaagc aacagcggtg aataaggcgg ccgaagagct 943261 caagaaaaaa ggcgtgaagg ccatcgcggt tctcgcacat atgtcagctg aacaaaacgg 943321 caacgccatt accggtgagt ctgctgatct tgcaaacaaa acagattctg aaattgacgt 943381 gatttttgcc gcgcataatc atcaggttgt taacggtgaa gtgaatggaa aactgattgt 943441 tcaagcgttt gaatatggaa aagcgatagg tgtcgttgat gtagagatcg ataaaacgac 943501 aaaagacatt gtcaaaaagt ccgcggaaat cgtatatgtt gatcaaagta aaatcgaacc 943561 ggatgtcagc gcgtcagcca ttttaaagaa atacgaaaca attgcggaac cgattatcag 943621 cgaggtagtc ggcgaagccg ctgttgatat ggaagggggg tattcaaatg acggcgatac 943681 acctcttgga aacctgattg cggatggtat gagagctgcc atgaaaacgg attttgccct 943741 tatgaatggc ggcggcatac gtgaagcgct gaagaagggt ccaattacgt ggggagatct 943801 ttacaatatt cagccgtttg gaaatgtgtt aacgaagctt gagattaaag gaaaagattt 943861 aagagagatt atcaatgcgc aaatctcgcc ggtttttggg cctgactaca gcatcagcgg 943921 gtttacgtat acgtgggata aagaaaccgg aaaagcagtt gatatgaaaa tggcagatgg 943981 caccgagatc cagcccgatg ccacatatac attgaccgtc aacaacttta tggcgacggc 944041 gacaggagcc aaatatcagc caatcggact gctgggaaaa aatccggtga cagggcctga 944101 ggatttggaa gcgacagttg agtacgtgaa gagttttgat gagccaattg cgtatacaaa 944161 agagggaaga attaagcttg ctgaagccag tgatattgaa gaccctgtaa cagaagaccc 944221 gataacggaa gagcctggag atgatccggg gacggaggat ccgattaaag aggatccaag 944281 gccaggtgaa gatttgcctg atataaaaga aactccggga acagcaccgg ttcatcagct 944341 tccgccttca gccatttcga gattcaatga aataccaatc aacaacacaa aaaccgctga 944401 tactgctaat agcatcagca cattgccgtt acaaaccgag actgcggaaa gcgggtctga 944461 tcatcagctt ccggatacgt cagcgggcta ctataacttt atggtaatcg gtgcggcggt 944521 gacattgtca ggaacttatc tatatgtcag aagaaaaagg agcgcctcca gaacgtgaaa 944581 aaagttattc cactattcat cattgctgcc ggcctagtga tcgcaggcta tggaggcttt 944641 aaattgatcg atacgaatac gaaaacggaa cagacattaa aagaagcaaa gctggcggct 944701 aaaaagccgc aggaagcttc ggggacgaaa aatagcacag atcaagcaaa gaacaaagca 944761 tcatttaagc ctgagaccgg ccaagcgagc ggcattttag aaataccgaa aatcaatgca 944821 gagcttccga tcgtggaggg caccgatgct gatgatttag aaaaaggtgt cgggcattac 944881 aaggacagct attatcctga tgaaaacgga caaattgtgc tgtcagggca tcgggatacc 944941 gtgtttcgcc ggacgggaga gctggaaaag ggggatcagc tccgtcttct cctgtcatat 945001 ggagaattca catatgaaat tgtaaaaaca aaaattgtcg ataaggatga cacatctatt 945061 atcacgctcc agcatgaaaa ggaagagctg attctgacga cctgctatcc gttttcatac 945121 gtcggaaatg ccccgaagcg ctatattata tatggaaaac gagtgactta aaaagccgag 945181 gcagtgcctg cggcttttct tcatgaaaaa tatgtgcggc aaaggttttt catatcagca 945241 gggaaagggg cttcagcaac tatgagctcg tctgttatcg ggtgaaccgc ttgtacttta 945301 ttggcgtgca gtgcctgcct gtttagcagc ttgctcccgc ctccgtaaag cgagtctcct 945361 gtcaacggat ggccgaggct cgccagatga acacggattt ggtgtgttct gcctgtttcc 945421 agctctaatt caacgagcga cagccgttct ttcgcattgc tggccattac cttgaaatga 945481 gtgacggctg tttgcccgcc tggtgaaacc cggcgtcttg tcgggtgtga gcggtctctg 945541 ccgatcggtg aattaattgt cccttttttc gtccgtagct taccttcagc gatagcggta 945601 tacgtacgct tcagcgtctt tttctctaac tgctggtcta agatggcgtg tgccaaacga 945661 tgcttggcaa aaacgatagc gccagatgta tcctgatcaa gacgatggac gtggcgcacc 945721 ttacatgttt cgccatttat ctgataatga tacgcgatca aattagccag tgtgccggtt 945781 tgcccatcct cattcggatg cgtcgcgatg ccagcgggtt tattgatgat gagcatatga 945841 ttgtcctcaa ataaaatatc aagctcgcca tactccggaa tgaccgaaga tgcttcactt 945901 tcctgaagat caatgaacac gcggtctccc ttttttacaa tcatattgtt taagacggat 945961 tcgtgattga cctttatctg ttgatgggac atccagtctt gtatcactgg tttagaagct 946021 ttgagcgctg ttttgagtac ggaaaacagc cattggccgt cctgtttttc attgatgagg 946081 atctcaagcc ctctgccttt ttggttcatg ttaaatggct ccttttcgaa gcggaaggct 946141 gctgtttctc ataggaaaca cttaccttag ctttcgcgtt tttttctgtg ctattcttga 946201 gtaagactta ggatattcga tggcaagaaa ggtgattgac gtgagaattg tgaacgcagc 946261 aactgcagaa caggagagct ttatcaagga gctgtctatg gagctgatcc atgatgtatt 946321 tcctctttat ttctccgaac tggacattca gcgctttaaa aagaaaggcg ttctgtcttt 946381 aaataaccat tattaccaag gaacattaaa agaagcattt caaattatgg cttgtctgca 946441 aatgatacat attatcctga ccaagccttc gccgcactct gatttgagtg atcaggcgat 946501 ttttgaaaaa aacagcaaga tgctgaatga ttttgggatt tattttccgt ttgctttttc 946561 tgactttcaa aagaagacta acaaagcctt tttcggtcaa agaaggctga tataatcatg 946621 cggcaagggc ttttctattt ttagaaaagc tctttttgta tcagagaaat catatcataa 946681 aacctttcct ctaactccct ttttaaacgg ctcgtgtctg aacatactaa tgattgaaag 946741 gggtgctgac aatgagttca gttaaagata caatgacaac gcaggtggca accgtttctc 946801 cgaatcaaac gattcaggaa gcggcttctc taatgaaaca gcataacgtc ggggcgatcc 946861 ccgttgtaga gcaaggtgtt ttaaaaggaa tgctgactga ccgtgacatt gcattaagaa 946921 ctacagctca gggccgtgat ggccagacac ccgtttcaga agtgatgtca acagaactcg 946981 tatcaggaaa ccctaatatg agtctggaag acgcgtcgca gctgatggcc cagcaccaaa 947041 tccgccgcct tcctattgta gatcaaaaca atctagtcgg gatcgttgcg cttggagacc 947101 tggcagtcaa tcagatgtcg aacgagtctg cgggatcagc gctgacaaac atttctcacc 947161 aaaacattca ttaataagaa agagcttgca gtgtgcaggc tctttcttca cataaaacct 947221 tactttttga aagcagactt gtttcggggt atagtgagtg tatacatatg tctcaattcg 947281 tactaaagga gttgtaccca gtgattaaag cgttaatttt tgattttgac gggcttattc 947341 tagatacaga aacacacgaa tatgaggttc ttcaggaaat atttgaagag cacggctcag 947401 tgctgccgct atctgtctgg ggaaaggtca tcggaactgc tgcgggtttc cggccttttg 947461 aatatttaga agagcagatc gggaaaaagc tgaaccatga agagctcaca caattgagaa 947521 gagagcggtt tgccaaacgc atggaatcag aaaaagcgag acctggtgtc gaagcgtatt 947581 tgaatgcggc aaaggattta ggcttaaaaa taggccttgc ctccagctct gattataaat 947641 gggtgtccgg ccatttgaag caaatcggcc tgtttgatga ttttgaagtt attcaaacgg 947701 cggatgatgt ggaagaggtg aagccgaatc ctgaactcta tttattggcg gcaaagaacc 947761 tgggggtatc gccagcggaa tgtctcgcgt ttgaggattc tgtcaatggt tcgattgctg 947821 cgaaacgtgc aggcatgaag tgtgtcattg tcccgaataa agtaacgggt accttgatgt 947881 ttgaagacta tgatcacagg cttgaatcaa tggcggagat ggagctcgcc ctattgcttg 947941 atcatctgaa ctcacaaaac tagaaaggag cgagtaggtt gtctgagaaa ttagatttga 948001 cccggtttga aaagaaaatg gttatccgca atatcgaaga gaaagacatc gacaagatta 948061 tcgatcttca aaaggactgc tttccaggaa tggagccttg gaagcgggag catttaatca 948121 gccatttgga gcattttccg gaaggacagt tttgtgcaga attcgaaggt gaaattatcg 948181 gttcgtgctc aagtctcctg attaactttg atgaatatga tgaccgccat acgtggcagg 948241 acattacaga tgacggttat atcaccaacc ataatcctga cggcttgaat atgtacggaa 948301 ttgaagtcat ggtgcacccg aaatacagac gaatgaagat cggccaccgt ttgtacgagg 948361 cgagaaagga cttagccaga cgcttaaacc tgaaaagcat catcataggc ggacggattc 948421 caaactatca caaatatgca gaggaaatga cagcgagaga gtatgttgaa caggtgacac 948481 gccaccaaat ttacgatccg gttctttctt ttcagctgat gaacggcttt acccttatgc 948541 gaattaaccc gaactatctc ccggatgata cagcttcgat caagtatgcg acgctgatgg 948601 aatggaataa tgtcgattat ctaccgcagc agacaaaacg ctattataaa tcggcgttcc 948661 ctgttagaat ttgtgtgatc caatacgaaa tgaagaaaat ttattccttt gaggaatttg 948721 cgaatcaagt agaatactat gtcgatgttg cttccgacgc aagatctgat tttgcggtgt 948781 tcccggaaat tttcacaacc cagctgatgt ccttccttga ggaacggtca ccgagcttgg 948841 cggtgcagag aattaccgag tatacagaag attacatcag cctgtttact gacttggctg 948901 tgaagtataa cgtcaacatt atcggcggat ctcatttcgt cgaagaggaa ggcaagatct 948961 ataatatcgc ttacctgttc agacgggacg gaacgatcga gaagcaatac aaactccata 949021 ttacgccgaa tgaacgcaaa tggtggggga tcagcgcagg agaccaagtt cgcgtgtttg 949081 atacggactg cgggaaaatc gcgatccaga tctgttatga cattgaattt cctgagcttg 949141 cccggattgc ggctgataaa ggagccaaaa tcatctttac gccattttgt acagaagacc 949201 gtcaaggcta tctgcgtgtc agatactgtt cgcaggctag agcggttgaa aatcaaattt 949261 atacggttat ctctggaacg gtcggaaacc ttccgcaaac ggaaaacatg gatatccaat 949321 acgcccagtc aggcatcttt gccccgtctg attttgaatt cgcccgagac ggcattgtcg 949381 gcgaaacaaa cccgaatatt gaaatggtcg tcatcggcga tgttgacctg gaaattctca 949441 gaagacagcg ccaaaacggt acagtgcgcc agctaaaaga cagacgacgt gatatttatc 949501 atattcaata taaaaaataa ttcccaaaaa acccgcctga attggcgggt ttttttaaac 949561 aaaagcggaa ttgtttaggt gctttcttta aaataaaagt aaattgtata gtggatgtgc 949621 cttatggagt ttctgtattt tcgccatttc ctatatcata cagaaaacgg ctaggcttca 949681 cattgctatt gcaatggctg tccaagttgt ttcgagtgcg acctttatca gtacgatgct 949741 gagcattgtc actttgcctg ttttgctttg gaagctgcat cctctttctt cttgagaaag 949801 gggatgtttt attatttacg cggtttattg actctgaccc ggtctggctt tatattgaag 949861 gcagggaaat catcaccaag acatcacata aagagaaggt ctgtttcaat tgaattggca 949921 ttatagggaa cgctaatgaa atggagatga tggggatgga aaacattcag caaaatcagg 949981 gattaaagca aaaagatgag caatttgtgt ggcatgccat gaagggagcg catcaagcgg 950041 acagcctgat agcccagaag gccgaagggg cctgggtaac cgacacagac ggacgccgct 950101 atttggatgc gatgtccggt ttgtggtgcg tcaacattgg ttacggcaga aaggagcttg 950161 cggaggctgc ctatgagcaa ctaaaggagc tgccttacta cccgttaacg caaagtcacg 950221 cacccgcaat tcaactggcg gaaaagctga atgaatggct tggcggcgat tatgttattt 950281 ttttttccaa cagcggatcg gaagcaaacg aaactgcttt taaaattgcc cgccagtacc 950341 atctgcaaaa cggcgaccac agccgttata aattcatctc aagatatcgg gcataccacg 950401 gcaatacatt gggagcgctc tcagctaccg gacaggcgca gcggaaatat aaatacgagc 950461 ctttgagcca agggttcctg catgcagctc cgccagatat ataccggaat cctgatgatg 950521 cagacacgct tgaaagcgca aatgaaatcg accgcatcat gacatgggaa ttaagcgaaa 950581 cgattgccgg ggtcattatg gagcccatca ttacaggcgg aggcatccta atgccgccgg 950641 acggatatat gaagaaggtg gaggacattt gccggcgcca cggagccctt ttgatttgcg 950701 atgaagtgat ctgcgggttt ggacggacag gtgagccgtt cgggtttatg cactacggtg 950761 tgaagcctga tatcattacg atggcaaagg gaatcacaag cgcgtatctg ccattgtcag 950821 cgactgctgt gaaacgggac attttcgaag cgtatcaggg ggaagctcct tatgaccgtt 950881 tccgccacgt gaacacgttc ggcggaagcc cggctgcctg tgctttggcg ttgaaaaacc 950941 tgcaaattat ggaggacgaa cagctgattc agcgatcccg tgatcttgga gcaaagcttt 951001 taggtgagct tcaagctctg agagaacacc cggcagtcgg ggatgttaga ggaaaagggc 951061 tgctgatcgg aatcgaactc gtcaaagaca aattgactaa agagccggct gatgccgcca 951121 aagtaaacca agtggttgcg gcgtgcaaag aaaaagggct gatcatcggc aaaaacggcg 951181 atacagtcgc cggctacaac aatgtcatcc agcttgcgcc gccattttgc ctgacagaag 951241 aggacctttc ctttatcgtg aaaacggtga aagaaagctt tcaaacgata taatataaaa 951301 gtgaattatt aaaggagcac atgatgagtt ttcacaacca gccgatctta ccggctattc 951361 gcaatatgaa gcaatttgat gagtttttga acagttcatt ctcttacggt gttattcttg 951421 atattcatct cggccagctg aagggcgtga tcaaagaagc gcaaaagcac ggaaagaaca 951481 tgatggtgca cgtcgatctc attcaaggga ttaagcatga cgaatacggt gcggaattta 951541 tatgtcagga tatcaagccc gctgggatta tttccacaag atcgaatgtg attgccaaag 951601 cgaagcagaa gaaaatttat gccattcagc gcctgttttt gcttgataca agcgcgatgg 951661 agaaaagcat ggagtttatc ggcaagcata agcctgactt catcgaagtg cttcccggca 951721 tcgttccgtc actcattcag gaaataaaag agaaaacagg gattcccatc tttgccgggg 951781 gtttcatccg tacggaagag gatgtagagc aggcattgaa agcgggggct gtagctgtca 951841 caacatctaa taccaaattg tggaaaaaat atgaaaactt tttgacggaa agtgattgac 951901 accgctttca tgcactgata caattgcact aggttaatac attgtgatgg agaactcgga 951961 gaccacagca gctctttacg gcaaatgttt atgcacccgt aaagcggttt gttgtggttt 952021 ttttattctc ttcttctcta tcatgctttt taatcgtgac tttaggagga atgtgctatg 952081 acagcatttt ggggagaagt catcggtacg atgctgctta tcatttttgg tgcaggtgtt 952141 tgtgcaggtg tcaatttaaa gaaatcgctt tcattccagt ctggctggat tgttgttgta 952201 tttggatggg gattgggtgt tgccatggcg gcatacgcgg ttggcggcat cagcggtgcc 952261 catttgaatc cggcgctaac gatagcgctt gcatttgtag gagattttcc ttggaaagag 952321 gttccggttt atattgcggc gcaaatgatc ggagcgatca tcggtgcggt gattatttat 952381 ctgcattacc tcccgcactg gaagtcaacg gatgatcccg ctgccaagct gggtgttttc 952441 tcaacagggc ccagcattcc gcatacattt gcaaacgttt taagcgaagt gattgggaca 952501 tttgtccttg tacttggaat cttggccata ggtgcaaatc aatttacaga aggacttaat 952561 cctttaatcg tcggtttcct cattgtagca atcggtattt ctctgggagg caccaccggc 952621 tatgctatca atcctgcacg tgacttaggt ccgcggatcg cccacgcttt tcttccgatt 952681 ccggggaagg gctcatcaaa ctggaaatac gcatgggttc cggtagtcgg cccgatttta 952741 ggcggatcat tcggcggtgt attttacaac gctgcattta aagggcacat cacaagcagc 952801 ttctggattg taagcgttat attggttgtg gtattgttag gactctatgt ttatacgaaa 952861 tcacattctg ctaaaacatt atcaaattct aaatatattt aatcaaaggg gagacatctt 952921 atggaaacgt acattttatc cttagatcag gggacgacaa gttcaagagc gattctgttt 952981 aataaagaag gcaaaattgt ccactctgct caaaaggaat ttacacaata cttcccgcat 953041 cctggctggg ttgagcataa tgccaatgaa atttggggct ctgtcctcgc ggttatcgcc 953101 tcagtcatct ctgaatcagg aatcagcgct tctcaaattg ccggcatcgg catcacgaac 953161 cagcgcgaga cgacggttgt gtgggataaa gatacaggaa gtcctgtcta taatgcaatc 953221 gtttggcagt ccagacagac gtccggcatt tgtgaggaac ttcgtgaaaa aggatataat 953281 gataaattca gagaaaaaac agggctttta atcgatcctt acttctccgg cacgaaggtg 953341 aagtggattt tagacaatgt ggaaggcgca agagaaaaag cggaaaaagg cgagctgctg 953401 tttggaacga ttgatacgtg gctcatttgg aaaatgtcag gcggaaaagc gcatgtgacc 953461 gattactcca atgcctcaag aacactgatg tttaatattt acgatttaaa atgggacgat 953521 gaactgctcg acattctagg cgtaccgaaa tccatgctcc ctgaagtgaa gccgtcctct 953581 catgtgtatg cggagactgt tgattatcac ttcttcggaa aaaatatccc gattgctgga 953641 gcggcaggcg accagcagtc cgcattgttc ggccaggcat gctttgaaga aggcatgggg 953701 aaaaacactt acggcacagg atgtttcatg ctgatgaata ccggggaaaa agcaattaag 953761 tccgaacatg ggcttttgac aacaatcgct tggggcattg acggaaaagt gaactatgcg 953821 ttagaaggga gcatttttgt cgcaggctct gccatccagt ggcttagaga cggtttgaga 953881 atgttccagg attcatcgct aagcgaatct tatgcagaaa aagtggattc aactgacggc 953941 gtgtatgttg ttccagcatt tgtcggactg ggaacgcctt actgggacag cgatgtgcgc 954001 ggttcggttt tcggcctgac aagagggaca acaaaagagc actttatccg tgcgacactg 954061 gagtcattgg cttatcagac caaagatgtg cttgacgcaa tggaagcaga ttcaaacatt 954121 tcattaaaga cgctccgtgt agacggagga gctgtaaaaa acaatttcct aatgcagttc 954181 caaggagacc tgttgaatgt tcctgtggag cgcccggaaa ttaatgaaac gactgcactt 954241 ggcgcggctt atttggcggg tatcgctgtg ggattctgga aggaccgttc tgaaatcgcg 954301 aaccagtgga atctggataa acggtttgag cctgaattgg aagaagaaaa acgaaatgag 954361 ctgtataaag gctggcaaaa agccgtgaaa gcagctatgg cttttaaata aagtaatact 954421 atggtataat ggttacaagt taataagaac ggtcctgaga tgaggagaga ccacagcacc 954481 aaagtgtaag catgcacttt ggctgttgtg gtctcttttt ctatttaccg tgacaacaag 954541 gaggaaacgt aatgatgaat catcaatttt caagtcttga aagagatcgc atgctgacag 954601 acatgacgaa aaaaacatat gacctattta ttatcggagg aggaattaca ggagccggaa 954661 cagctcttga cgcggcatca aggggaatga aggtcgcact aagcgaaatg caggactttg 954721 cggcgggaac atcaagccga tcaacgaagc tggtacatgg cggcttgcgc tatttaaaac 954781 aatttgaagt gaaaatggtc gctgaggtag gaaaagagcg ggcgattgtg tatgaaaacg 954841 gcccgcatgt cactacaccg gaatggatgc tgcttccgtt tcataaaggc ggcacattcg 954901 gttcatttac aacatctatt gggttaaggg tttatgactt ccttgcaggt gtgaaaaagt 954961 cagaacgaag aagcatgctt tcagcaaaag aaacgctgca aaaagagcct ttggtgaaaa 955021 aagacggctt aaaaggcggc gggtactatg tggaataccg cactgacgat gcgagactga 955081 ccatcgaagt catgaaggaa gcggttaaat tcggggcaga gcctgtgaat tactccaaag 955141 tgaaggagct tctttacgaa aaaggcaaag ccgtcggcgt attaattgaa gatgtgctga 955201 caaagaaaga atataaagtg tatgcgaaaa aaattgtcaa tgctacaggc ccttgggtcg 955261 atcagctcag agaaaaagac cattcgaaaa acggaaagca tttgcagcat acaaaaggca 955321 ttcaccttgt atttgaccag tctgtctttc cgctgaaaca ggctgtatat ttcgatacac 955381 ctgatggccg gatggtattt gcgattcctc gtgaaggcaa aacatacgtg ggaacaacag 955441 acactgttta caaagaggcg ctggagcatc cgcggatgac aacggaggat cgtgattatg 955501 tcatcaaatc aatcaattac atgttcccgg aactgaatat cactgcgaat gacatcgaat 955561 ccagctgggc ggggctgcgt ccgctgattc atgaagaagg caaagatcct tctgaaattt 955621 cacggaaaga cgagatttgg acatctgact caggcctgat caccattgcc ggcggaaaac 955681 tgactggata cagaaaaatg gcggagcaca tcgttgatct tgtccgtgat cgcttaaaag 955741 aagagggcga aaaggatttt ggaccatgta aaacgaaaaa catgccaatc tctggcgggc 955801 acgtcggcgg ttcgaaaaat cttatgtcct tcgttaccgc gaaaacaaaa gaaggaattg 955861 cagccggttt atcagaaaaa gacgcaaaac agcttgcgat cagatacggc tctaacgtag 955921 atcgcgtctt tgaccgggta gaagcgctga aagatgaggc cgcgaaacgc aacattccgg 955981 ttcatattct tgctgaggca gaatacagta tagaagaaga gatgactgca acccctgctg 956041 acttctttgt ccgcagaacg ggacgtttat tttttgatat caattgggta agaacatata 956101 aagatgccgt tattgatttt atgagcgagc gattccaatg ggatgagcag gcgaaaaaca 956161 aacatacaga aaacctcaac aagcttttac acgatgcggt cgtaccgctt gagcaataaa 956221 tcataacggg ctgtctgcag cccgttattt ctttttacgt gccgaaaggg ggagatctca 956281 ggttatcaag tgacagaggc acccgcttca tataaaataa tggcataagc tgatacatag 956341 gaggacgaat atgacttgga gaaagagcta tgaacgctgg aaacagacag aacatttaga 956401 tctggaatta aaagagcgcc ttattgaatt agagggagat gaacaggccc ttgaggactg 956461 tttctataaa gaccttgaat tcggtaccgg cggaatgcgc ggggaaatcg gcgccgggac 956521 aaatcggatg aatatttaca ctgtgcgcaa agcatcggcc gggtttgcgg catacatctc 956581 gaagcaaggt gaggaagcga aaaaacgggg cgttgtcatt gcttatgatt cccgccataa 956641 gtctccggag ttcgcgatgg aagcggcaaa aacacttgcg acacaaggca tccaaacata 956701 cgtgtttgat gagcttcgcc cgacgccaga gctgtcattc gctgttagac agctgaacgc 956761 ttatggtgga attgtggtaa cggcaagcca taacccgcct gaatataacg gctacaaagt 956821 atacggggat gatggcggcc agctgcctcc aaaggaagcg gacatcgtca ttgagcaggt 956881 aaacgcgatt gaaaatgagc tgacgatcac agtggacgaa gaaaataagt taaaagaaaa 956941 aggcttaatc aaaatcatcg gtgaagatat tgataaagtt tatacagaaa aactgacgtc 957001 catttctgta catcctgaat tatcggaaga agtagatgta aaggttgttt tcacaccgct 957061 gcatggaact gcaaataaac cggtcagacg cggtcttgaa gcactcggct acaaaaatgt 957121 aacggttgtc aaagaacagg aactgccgga ttcaaacttc tccactgtta catcgccgaa 957181 cccggaagag catgcggcat tcgaatatgc cattaagctt ggggaggagc agaatgcaga 957241 tattctcatc gcgacagatc ctgatgctga ccgcctcggc atcgcggtga aaaacgatca 957301 aggcaaatat acagtgctga caggaaacca aaccggagcg ttgctgcttc attacctgct 957361 ttctgaaaag aaaaaacaag gcatcctgcc tgataacggt gttgttctca aaacgatcgt 957421 cacaagcgaa atcggccgtg ctgtagcttc ttcattcggc cttgatacga ttgatacgct 957481 gacaggcttt aagtttatcg gtgaaaagat taaggaatac gaagcatcag gccagtatac 957541 cttccaattc ggttatgaag agagctacgg ttatttaatc ggggattttg cccgcgataa 957601 ggacgccatt caggctgcgc ttttggcagt tgaagtttgc gcgttctata aaaaacaggg 957661 aatgtcattg tatgaggcgc tcatcaatct ctttaacgaa tatggttttt atcgtgaagg 957721 gctgaaatcc ctgacgctga aaggcaaaca aggagcagag caaattgaag cgattcttgc 957781 ttccttcaga caaaatccgc cgcagaaaat ggcgggcaaa caggttgtca cagcagaaga 957841 ttacgctgta agcaaacgga cgcttctgac tgaaagcaaa gaagaagcca tcgacttgcc 957901 aaaatcaaat gtattgaaat acttcctgga agacgggtct tggttctgtc tccgtccttc 957961 tggaactgag ccgaaggtta aattttattt cgccgtaaaa gggtcatctt tggaagacag 958021 tgaaaagcga cttgccgtcc tttctgaaga tgtaatgaag acggtggatg aaattgttga 958081 gtcaacagca aaataattca agtatgagct gggtcattgt aaatgatccg gctttttctt 958141 tttctcatcc aaaagtctga aagaaaatca tcctacaagt gaagcaatga aatacaaaaa 958201 actggtataa tcttaaatac aagatcaatg ccggagtgag aaacgtgagc aaaacgagga 958261 tggaaaaatt aaaaacgctg aaaacgattg cggaaacctt aaatcaaggg cacgatatca 958321 aagcaacact ggatgaggtt ttaaaagagt tgctgagtct gacaaacctt caatccggat 958381 ggatttttct gatcgaagaa gatgggtctt atacgttagc ggccgacgct tatctgcccc 958441 cggctttaag ccgcaaggaa aaagtgctga tgtgcgaagg ggagtgttac tgcctgacga 958501 aattcaataa cggagggctt agaaaagctg caaatatcat gaactgcaaa cgcatcgaat 958561 cagcagaaaa cctgcattgt tttgacacag aagggattac gcatcatgca actgtgcctt 958621 tagaagacgg ggacagaaga ttcggattgt taaatgtagc ggcggccgga aaaaccatgt 958681 ttgatgagga agagctgcat ttactcgagt ctgtcgcctt tcagatcgga acggcaatcc 958741 agcgtatgag gctttctgaa tatcaacaaa aaaatgctct tttaatggag cgtaaccgcc 958801 tcgctcagga gcttcacgat tcagtcaatc aaatgctgtt ttccgtcagt ttaactgcca 958861 aagctgcgaa gacactaaca aaagatgaaa atttacagca gatgattgat ttcatccaaa 958921 acctatcaca ggacgcgctc gcagaaatga aagcgttaat ttggcagctt cgccccggag 958981 gattggaaaa agggctggct gaagccatta aaagctatgg tgcgctcatt ggattgaaga 959041 tcatttttac acaaaaaggc tgtcctgttc tgactgatga gcaggagcat atgctatggc 959101 gtgtcgtaca ggaagcttta aataactgca aaaagcatgc cggaacggat acggcgtatg 959161 ttagtctgac tgcttctttg tgccatgcgg agctggatat catcgatcat ggggcaggat 959221 ttcgctatga agcgcatgcc ggtctgcctt cacttggcat aaaaggtatg aaagagcgag 959281 cggaaaaagc cggagctaag ttttggattg agtcagcgct tggaactgga acaaagctgt 959341 ccatcaggct tccgctaaaa agccgaaaag gaggggcggt atgaaaattg tcattgctga 959401 tgatcatcat gttgtcagaa agggtctgcg ttttttcttt gccacccagg atgatattga 959461 agtcgtcgga gaagctgcaa ctggattaga agccctccgt gtcatcgaag agacaaagcc 959521 ggatcttgtg ctaatggatt tgtctatgcc cgagatggac ggcattcaag ccattaaaaa 959581 agcaatacag caatttccgg atacgaatat cattgtgctg acgagctact ctgatcagga 959641 gcacgtcatc cccgcgcttc aggcaggcgc gaaggcgtat caattaaagg atacggagcc 959701 cgaggaattg gtgaaaacac gacaagtgca tggtggcgaa tacaagcttt ctacagctat 959761 tatgccccat gtgctgacac atatgaaaaa tcagcacgac ccggaaaaag aaaaatacta 959821 tcaattaact agaagggaaa aagacgttct gactgaaata gcgaacggga aaagcaataa 959881 agaaatcgca gcagccttgt ttatttcaga aaaaacagta aaaacccatg tatcgaatct 959941 tttagcaaaa cttgaagtgg ccgatcgcac gcaagcagcg cttttcgcag tgaaatataa 960001 cctgaatgga gagatctcaa aatgaacatg ttagtcataa atggcacgcc aagaaaacat 960061 ggcagaacaa gaattgcagc atcctatatt gcagctctgt atcacacgga tttgattgat 960121 ctaagcgagt ttgtattgcc cgtttttaac ggtgaagcgg aacaatctga actgttgaaa 960181 gtacaggagc ttaagcaacg cgttacgaaa gcggatgcga ttgtattatt atcgcctgaa 960241 tatcacagcg gcatgagcgg cgctttaaaa aatgccttgg attttctaag cagcgaacaa 960301 ttcaaatata agcccgttgc attattggca gtagcgggag gcggaaaagg cggcatcaat 960361 gcgctgaaca atatgagaac tgtgatgcgg ggtgtctacg ccaatgtcat tccgaagcag 960421 ctggtgcttg atccggtgca tattgatgtt gaaaatgcta cagtggctga aaacattaag 960481 gaaagcataa aagagcttgt cgaagaactc agcatgttcg caaaagcagg aaatcccggc 960541 gtctaaacgc cgggatttgt ttatgtgaga agggctattt gatcttcata agtcagctct 960601 gtggcatgat caatatatcg gagaagggaa tacagcatct tttctaaaac ggcgtaatcc 960661 tgttcaaaat gatacgcatg cagaaaatgc tcaattcgtt ttgataacaa atcgtcctct 960721 gtacgcacca ttaaaattaa taaattatcc cattgagaac gatgggtgta ataaagcgct 960781 ttatcgtaat cggcataatc catgaatcgc ttctcctttc ttgggtgaga agttcatgat 960841 tagtttatgc cgcatcctct gttattgacg gggcaaaact tgccgtctgc gtcagtaaag 960901 gggtagcaat atgagggaga cataaaatca aaatgcctga atgaagatat cgcttttggt 960961 aaacctatga gggaatatat tctgggtaca ggagactgaa aaaatgaaat ccctgccgta 961021 taccatcgca cttctttttt gcggattgat tatcgtgtca atggctgcaa aaggtcattc 961081 aacggacaca gacgagtccg ttcaaaagtg ggaacagctt gcctggagca aaattcagga 961141 tgaatataag ggcgcttcat tttctgatta tgcttatatg gggcgtacag aggtgaatga 961201 tcagcagact aaagatgtct ttcgggtgac agtcagacag aaagatgaca ctttttctgt 961261 tcgggccgaa gtctattttc atccggtgac aaatcatatg atcagcatca acgtctttag 961321 gctctaataa aaaactgtac agccgttaag gccgcacagt ttctgttttt agaaatatcg 961381 ttttgcaccg agatagcgct gtttccagta agagttgttc atattggaaa tgacaactcc 961441 ggaatcgttg gcatttatga attccccgtt gcctaggtaa attccgacgt gggaagggcc 961501 ggctttatat gttgaaaaga aaacgaaatc tccgacagca ggctggctaa ctgatttcat 961561 tgtgttccaa tatcccgctg ccgttaatct agatacggat gtgactttgt tcagtacata 961621 gtaaatgaat ccgctgcagt caaacccgga cggtgtcgtg cctccccagc gatacggaac 961681 cccaagctgc gctttagcgg ccgaaatcat tgtgttaatc ttcgcactcg ttgagctggt 961741 ggtgtttgaa gaaccggatg aagacgatga tgaagctttt ccggaaatga ccagcttttg 961801 gccaacctgc aagacatccg tttttaaatt gtttttctca cgaatctgct gagctgttac 961861 attaaatttt tgagcaatca cccataagga atcaccgctt ttcaccgtgt atgtagtcgt 961921 cgtgccggag cttgcatttg acgaagaaga cgacgatgat gaagagcctg aagatgcttt 961981 acctgtcagc ttcaatactt gtccaacgta aagcacatct gatttcagat tgttgatatt 962041 tcggatttgc tgtacagtca ggttatagtt gtttgcgatt ttccaaagtg aatcaccgct 962101 tttaacggta tatttagttg ttgctgaagt ttggttcgat ttggatgaat tgtctttaga 962161 agacgtatca gagccgcttg attttgtttt caacacctga ttcacgtaaa tggtgtctga 962221 ttttaagttg ttcaagacct tcaattcagc gatggacata ttgactttgt ttgcaatttt 962281 ccaaagtgaa tctccaagct gcaccttata tgttcccgta gaagatgaag aacttgaact 962341 cttattagaa ctgctttttg aactggagct tgaactctta ttagagttgc tttttttact 962401 ggaactagag cttgaagaaa cagtaccgga cacctttaat ttctgcccag cacgaattaa 962461 atcgctgctt agtccgttta attttttcag ttcctgcacc gtcattttaa actcatttgc 962521 gatcagccaa agtgaatctc cgcttttcac tgtgtaaaca gaacttccgc tcttcttggt 962581 tgttgagctt gaagtagatg aagaagtgct ggatttgctg cctggaatag taagcgtctg 962641 gccgatcgac agaacagtag tcgaaagatg attggcggat gtgagggccg ccacacttgt 962701 gttataggtt tgggccagtt tccataaaga atctccgctt ttgaccttaa tcgttgctgc 962761 ttcagctggt gtcactacta aagttgtgcc gacaatcgca gatgctgtca gccctgctgc 962821 taatttcttt ttcatcttag ctctcctttt tcccccaatg attttgcatt tgctgtttct 962881 tttttatatc ggcacatttg tctcatcgtt ttgccttttt ataaaaatag ccaaattatc 962941 ttaacaataa gggggaaaaa gggcataaaa aaagaaggaa tcttaatcta ttccttcatt 963001 tttaaaagct tcatgatatc ttctttgttt ttgacgaggt cgcgcagtgt gtatttgtct 963061 aaaactgcga ggtaggctaa aagcgcttca ttcagcacat gttttaagcc gcaaaccggg 963121 gaaataacac agagattctt gttcgcatca aaacattcaa caatattaaa atcgtcctcc 963181 gtttttctga caacctcacc gatgttgatg tcttcagggt ccatgcctaa tcgtatgccg 963241 ccgccccgtc cgcgtatcgt ttctacgtag ccgagctggc cgagcctgta tatgactttc 963301 atgagatgat tttttgaaat agaatacgtt tcggcaatct gttttatatt tgaaagttct 963361 ccgggacgct ctgcagccag aaaaatcaac actcttaatg aataatctgt ataattggtt 963421 aacttcataa taagacctca gaataagaca ttttctatat cttatcataa tcgattgaaa 963481 aatgaaaaaa aaggaattaa aaaacatgca cccagctggg tgcatgtttt ttgcttacat 963541 gtcattcggc ggattttggt ttttacggtt tttttcgatt tctgtgtttt gcattttgcg 963601 ttcaaatgta gacagataac gtgatgcaaa atccttaccg ccaaggccga aggataaacc 963661 aaaagcaagt gcgaagccgc taagaacgat gatgaacgcg gaattgacga ttgtcgcagc 963721 gacacccagc tgatccaggg ccataaagaa agcaagtgcg ataatcgtat atttagcaat 963781 aggcgctaaa gacttgaatt cctgaccttt tatcatgctt gcgagcactt ttctcaccaa 963841 ttctcctgcg taaaggccga gtccgagaat gaatactgcg acaaggacat tcggcagata 963901 cgcgatgatg ccggtggcaa tttctacgag gaagtgcagc cgaacaattt gaagcgcctc 963961 agctgtaaag agcagaatga caatgatttg cgcaatcata ccgacaactt gagacaagga 964021 cagctttgca ggcgttccgg cttccatgcc cattttccct aagacagaat caaagcctgc 964081 gcgatggagc agtccggaca ccatggattt cacccatttt cctgcccaga tacccgctaa 964141 tacaagcacg atggcaatca tgatgttcgg aagcatgttt aaaatcgtat tcagcataga 964201 gacagctggt tttgaaatgc cggcgacatc cagctgatca agcgctgaaa tgaccaccgg 964261 aatcataatg agcacataag cgattgttcc gatgactgct gaaaggcttg tgtcttttaa 964321 gtaaattgat aaacccatac gtgccgcgaa tctttcggtg ccgatgcttg caaggaaatt 964381 cgtaatgata tcacggacaa ggcgggcaac aagccatccg attaatacga taagcgccgc 964441 tgcaaataat ttcggcagaa aagcgagcac gctttccatc atatttgtaa aaggacctga 964501 aatgccgctg attttcaaag aagataagac ccctggcaga aaaacaagca gcacgagata 964561 aaagacaatt tgtgaagcgg tattgacagc ctggtgaata tcttttcctt cagacaccaa 964621 attccacttg cgcagtttgt cactcgtgtt cagcttcatc ccgatttttt tgacaaggaa 964681 gctcaaaaca gaagctgcag cccatcctaa cagcagaatg agtccggctt tcagcacgct 964741 tgggatcgca gctgcaatcg ccgaaagcat actgacaaac ggcgatgcca ctgttgtcag 964801 gtgcaaaatg ttaaagaata aaataaagac gatgatcagt gcgataaaat aaacgacctt 964861 gcttatgact ttttccgagg aatagcgtga aggctttttc ccagcaaaga gcttgtcgtc 964921 gatttttgtt ttgctgagtc ctttgtatac cgctttttca atgattttag caatagccca 964981 gccgattaat aagacgagta aagcaatgat tacgtttggc agcttactga gataagaaga 965041 aaacacgtct gctacattca attggtatcg ctcctttttc gtagtatggt gtgtgtttac 965101 ccacttatcc aataagcaaa cagatgaatg tgccggggga attttttctt gcccgagtga 965161 gactatcatc ttttgtctgg cgggctcata cattatagat aagtccaagt aggggggatt 965221 cggttgaacg cggaggagaa gaagggatta cagcgggcaa ttgaggaaat taccgaaatt 965281 gcaaaaggat tcggccttga tttctacccg atgagatatg aaatctgccc ggctgaaatt 965341 atttatacat ttggcgcgta cgggatgccg acaagattca gccactggag cttcggcaag 965401 cagtttcaca agatgaagct gcactatgat ctagggttaa gtaagatcta tgagctggtc 965461 attaactcag atccatgcta cgcttttttg ctggacagca actcactgat ccaaaataaa 965521 ttgattgtcg cacacgttct tgctcattgc gatttcttca aaaacaactg ccgtttccaa 965581 aacacgaagc gcgatatggt ggaaagcatg gcggcaacag ctgaacggat aaaacactat 965641 gaacaggttc acgggataaa agaagtcgaa tcttttttag atgcaatcct ttcgattcag 965701 gagcatatcg atccgtcgtt ggtccgacca aagctccaat ggagtgtgga tgatgaggaa 965761 gaggagattg aagaggcagc cacgccttac gatgatctat ggtctttaga tgaaaagaaa 965821 ccgaaaaaac aagtgaaaaa atcgaaaaaa ccgttcccgc cgcggcctga aaaagatatc 965881 ctgcttttta tcgaggagca ttcccgggag ctggagccat ggcagcgtga tatattaacg 965941 atgatgagag aggaaatgct ttatttctgg cctcagctgg aaaccaagat tatgaatgag 966001 ggctgggctt cctattggca ccagagaatt atacgtgagc ttgatttaac ctctgatgaa 966061 gcgatcgagt tcgccaagct gaatgcaggt gtcgttcagc cgtccaaaac aggcattaat 966121 ccttattatt tagggctgaa aatatttgaa gacattgaaa agaggtacaa caacccgacg 966181 gaggaaatga agaaaatggg cgtgcagcct gactccggcc gggagaaaat gtttgaggtc 966241 agggagattg aatccgatat ctctttcatc cgcaattatt taaccaaaga attagtcatg 966301 cgcgaggatc tttatttgtt tcaaaaacag ggccgagatt ataaaatcat cgataaacag 966361 tggaagtcgg tgcgcgacca gctcgtaagc atgcgggtaa atggcggttt tccatatttg 966421 acagtaaacg acggcgatta tatgaaaaat aacgaactct atattaagca ttggtatgag 966481 ggcatagagt tggatttgaa atatttggag aaagtgcttc cttatttatt ccagctttgg 966541 ggaagaagcg tgcacattga gtctgtgctt gaggataagg aagtcatgtt ttcgtacgac 966601 ggaaaaggtg ttcaccgcag atatttataa aaaagaggat gcagcgttct gcatcctttt 966661 tattttccag tttttaaaat cttaaatatg atgtttgcct ggtccgtatt gttaatcaat 966721 ccgcggaatt tttcttttcc ggggccgtac gcgtataccg gtacttcttc gccggtatga 966781 tcggtactcg tccatccgct gttggagcgg gtattaaaaa tcttgatgat ggctttggag 966841 gcccctttgc ttttgtcagc ctgtgcagct gcttcaacgc ttttgatttc ttcagatgtg 966901 actttcagat tggcatagcg ggcgagcaca tctttaaccg gcttgccttc actgattttt 966961 ttggccatga attcaggtgt tttcttagcg gagagaatcg gttctgcgtg ccaattcttt 967021 tccccgtttg cgccaatggt aaagccgccg gttgtatggt cagcagttgc aatcacaagt 967081 gtatgtttgt cttttttcgc aaattcaatc gcggctttat aggcctgttc aaaatcttta 967141 acctcgctca tggctcctac tgtatcattg tcatgggccg cccagtcaat ctggctccct 967201 tcgaccatca agaaaaatcc ttttttattt tggttcaggc gatcaattgc tgaaaccgtc 967261 atgtctttga gagacggtgt tttactgtca cggtcgagcg ctttagcaag ccctccatct 967321 gcgaaaagcc cgagcacctg ctgatcttta ttttttttca atgcttgttt agttgtcaca 967381 tagctgtagc cggcttgttt gaattccttt gtcaagtttc tgtccttgcg gttaaaataa 967441 gattttccgc cgccgagcag cacgtctatt ttatgtttgc cttttatctt gtcatccata 967501 tagctgttgg cgatttggtc catgtttttc cgtgattcat tgtgggcgcc atatgcggct 967561 ggagtggcgt ggttaatttc agacgtggcg acaagccctg ttgacttgcc ttgctgtttg 967621 gcctcttcaa gtacagattt cacttttttt ccgtttttat cgacgccaat tgcattgtta 967681 tatgtcttaa cgcctgtcgc taatgctgtt ccggctgctg ctgaatctgt aatattatag 967741 tcagggtcat ccggatgcgt catcatcatg cctgtcaggt tccggtcaaa ttctgttaac 967801 ttcgggttat tcggtgtgtc accgttattt ttcatggaac ggtaggctct tatgtaaggc 967861 gtccccatgc cgtcgcctat catcacaatg acatttctga tctcagcttt gtcttgtttt 967921 ttggcgctgg ccttttctgt ttgctgaagc tcagctccgg caaagattcc agctgtaagg 967981 acagaaacag cggcgattgg cagaagtttt gatttcatat tttgaaacaa actcattttt 968041 ttcatgcctc ctttaatgta ttccgtttat catgttaggg aaactttgtt aaatgcggct 968101 gttgatcatg taaacaataa gtaaagcctt gtaaggaaat gaaaaaacgc ttttcgttat 968161 cttgccttat ttgatgtaaa gcattcattt ttcagaaaaa tctttacctc tctgtctttg 968221 catgatatgt ttgtttaaat aaaaaaactg cggataacca cagctctcct cgaatatact 968281 ttatcactca tttttccgat atatgagccg accccgaaag tttttcattt atttccttta 968341 tgttgaaaaa catcccataa aacatgacaa aagcactcgt tttttgtcac ctttgcaatg 968401 aaaatgaaat atttaatacc cttaaaaact tttttttaga acgaataatt aagaaatttg 968461 tcacatgaag tcaagactat ttctgatggg aatctatcct tataatagaa atcaataaga 968521 ttaatttaaa aaaagagata catatatata gagttaacat ttggggagga aaatatgaaa 968581 aagcaaatca ttacagctac gacagcagtt gttttaggat cgacgttatt tgcaggagcg 968641 gcatctgcac aaagcattaa ggtgaaaaaa ggcgacacgt tatgggatct ttcaagaaaa 968701 tacgacacaa cgatcagtaa aattaaatca gagaaccacc ttcgttcaga cattatttat 968761 gtgggacaaa ctttatcgat taacggcaaa tctacaagtt caaaaagcag cagttcttct 968821 tcctcttctt ctacatacaa agtaaagagc ggggacagcc tttggaaaat ttcaaaaaaa 968881 tacggcatga caatcaatga actgaagaag ctgaatggct taaaatcaga tttgcttcgt 968941 gttggacaag tcctgaaact gaaaggttca actagttcaa gcagctccag ctcatcaaaa 969001 gtgtcatcgt cttcaacttc tacttataaa gtgaagagcg gagacagcct ttctaaaatt 969061 gcgagcaaat acggcactac ggttagcaaa ttaaaaagct taaacggctt aaaatcagat 969121 gtaatctatg tcaaccaagt attgaaggtg aaaggaacaa gcacaagcag ctcaaaacct 969181 gcttcatctt catcgtcttc aagcagcaaa acgtcatcta catcacttaa tgtgagcaag 969241 ctggtttctg atgcaaaagc gttagtcgga acgccatata aatggggcgg aacgacaact 969301 tcaggctttg actgcagcgg attcatttgg tacgtactga ataaacaaac aagtgtgggc 969361 agaacaagca ctgcaggata ctggagttct atgaagagca ttgccagccc gtctgttggt 969421 gatttcgtct tcttcacaac atataaatcc ggcccttctc acatggggat ttacattgga 969481 aacaacagtt tcattcatgc aggatctgac ggcgtacaaa tcagcagcct gaacaacagc 969541 tactggaagc ctcgttacct cggtgcgaaa agattctaat ttttagagaa aacccgttca 969601 ttggaacggg tttttttcat tagacggagc acaggcgttt tggttgctcc taaaaatgaa 969661 aatgtgataa aaaatccaag aacttttttt ctttcttatt ttcataaagg gcaatcgcgt 969721 aagcgccggc atagggcagc tgtacagact gataaggaat tctgatcatc tgtttctctg 969781 ctaactcacg ctttactgta gataaaggca gaaatgaaac tccgagtcct tccttgataa 969841 accgtttcgt tatatgtgtt tgagtgacct tcattgttct cacaaatgga aatgtcattc 969901 tgacttgacg gagcaagtcg tcccagtaat caggatgatt gtgggtcaaa agcaggtatt 969961 gttcgagcac ctctttggca tcaatttcgt tgtcttctat gaaacgctta tcgggcgggg 970021 caacaaggac gacagggtct ttgtataagc agtggcagct taaagaagaa gactgtacct 970081 ttaaacagct tagtccgata tctgcttccc cggctttaat cagtgacgcg atttccgctg 970141 attcgaaaat cgtaaccgcc atttctgttt ccgtattcat tgctgtgtac cgcttcatga 970201 cagaaggaag cactgtatct gcaataagcg gagaaaccgc gagctgtaag gtttgagagt 970261 agccttgtct cactctgtga agctctgcca tgctgttttc ataatcatca agaagcctga 970321 gcgcatacgg caaatacgcc ctgccttcat cagtcagctg gatttgcctg cctttacgct 970381 cgaacagctt gcagctgatt tctttttcta attgcttgat atgtacggtc acagtaggct 970441 gagataagaa aagcgtttcc gccgtttttc ggaagttctc atattttgca gcggtcacaa 970501 aggtgtgaag ccatttgaaa tccatttcta ttctccctct gattaatatt tttaattaat 970561 tccctttaaa atattgatta ttttttaaat attatattta ctataataac agaaaaggat 970621 agggggaata caaatggtac attacggatt aaagggaatt acatgtgtag aaacatccat 970681 cagccatatt gatggtgaaa aagggcgtct gatttacaga ggacatcatg caaaagacat 970741 cgcactgaat cacagctttg aagaagcggc ttatttgatt ttatttggaa aactgccttc 970801 aactgaagaa ttgcaggtat ttaaagataa gctggctgcg gaacggaatc ttccggaaca 970861 tattgagcgc ttgattcaat cactgccaaa caacatggac gatatgtcgg tgctgagaac 970921 ggttgtttca gcattggggg aaaatacgta cacattccat ccgaaaacag aggaagcaat 970981 ccggctgatt gcaatcacgc cttctatcat tgcatacaga aaaagatgga cgcgcggtga 971041 acaagcaatt gcaccttctt cccagtacgg acatgtcgaa aactactatt atatgctcac 971101 aggtgaacag ccttcagagg caaaaaagaa agcgcttgaa acctatatga ttctggccac 971161 ggagcacggc atgaacgcat cgactttttc ggcacgagtc acgttatcta cagagagtga 971221 tttagtgtca gccgtcacgg ctgctctcgg tacgatgaaa ggtccgctgc acggaggtgc 971281 tccttctgcg gtgacaaaaa tgcttgaaga cattggagaa aaggaacatg ctgaagcata 971341 tctgaaagaa aaactcgaaa aaggagagcg cttgatggga ttcggccaca gggtgtacaa 971401 aacaaaagac ccgcgggcag aagctttgag acagaaagca gaagaggtgg ccggcaatga 971461 ccgtgatctt gatcttgcgc tgcatgtaga agcagaagcg attcgtttgc tagaaatcta 971521 caaaccggga cgaaagctgt acacaaatgt tgaattttac gcagctgcag tgatgagggc 971581 catcgatttt gacgatgaat tgtttactcc gaccttttca gcaagccgaa tggtagggtg 971641 gtgcgcccat gtactggaac aggcagaaaa caacatgatt ttccgcccgt cagcgcaata 971701 taccggtgcc attcccgagg aagttctttc ataacatatt ttggcgttta ttcatttctg 971761 tcgtgtggta acgttcagta tcaaccacat gtctaggagt gatgaatgtg aacccaatgg 971821 acagacaaac agaaggacaa gaaccgcagc atcaggacag acagccgggc attgagtcaa 971881 aaatgaatcc gctgccgctg tcagaggacg aggattatcg aggaagcgga aaactgaaag 971941 gaaaagttgc gatcattact ggaggcgaca gcggaatagg gagagcagca gctattgcct 972001 ttgctaaaga gggggctgat atctccattc tatacttaga cgagcattcg gacgcagagg 972061 aaacacgcaa acggatcgaa aaggagaatg tccgctgcct gcttatcccg ggagatgttg 972121 gggacgagaa ccattgtgaa caagctgtgc agcaaacagt ggaccatttt ggtaaactcg 972181 atatcttagt gaacaacgcc gctgaacagc atccccagga cagcattctc aatatttcaa 972241 cagaacagct ggaaaaaacc tttcgcacaa atattttttc catgtttcat atgacgaaga 972301 aagctttgcc tcacctgcaa gaggggtgtg ccattattaa tacgacatcg attaccgctt 972361 atgaagggga tacggcgtta attgattatt ccagcacaaa gggtgcgatt gtttccttta 972421 cgcgttccat ggcgaagtcg cttgcagata aaggcatcag agtgaatgcg gtggcgcccg 972481 gtccgatttg gacaccgctt attccggcga cattccctga ggaaaaagtg aaacagcacg 972541 gcttggatac cccaatggga agaccgggac agccggttga gcatgcaggc gcctatgttc 972601 tgctggcgtc tgacgaatct tcctatatga cagggcagac cattcatgtg aatggcggcc 972661 gttttatttc aacgtaatca acgaaaaacc agctcaagag ctggtttttt gtgtggtgaa 972721 aaatttcaaa ataaaaaatt tgtcgatttt tctaacaatt ttgttttcat ttttgcaatt 972781 ttatatataa tattgagtag gagaaaggaa tgattcgcga ccagtacaaa tatagtagaa 972841 aaaaaagaat aatgaccatt gttactcatg aattcagaaa attcaaataa aatatataaa 972901 aatagatgat cgggagttga aggggaatga aagggagcgt ttttaggaag aaaagcattc 972961 aggatttaat cgctgcgacg agcggggaaa agtctttaaa aagagaatta ggggcatttg 973021 atttaacgtt gcttggaatc ggcgccatta ttggcacagg gatttttgtt ctgacgggaa 973081 caggcgcagt cacggccggt cccgggctga cgatttcatt tgttgtggcg gcgttggctt 973141 gtttattcgc cgccctgtct tacgcggaat ttgcgtcaag tgtgcctgtt tcaggttcgg 973201 tgtatacatt cacttatgcg acattgggag agcttatggc ctttattatc gggtgggatt 973261 taattttaga atacatgctg gcggtaagtg cagtgtcggt cggctggtct ggttatttcc 973321 aatcgttttt atcagggctt ggcattcatc ttccggttgc tttaacagcg gcaccgggcg 973381 cagtgaaagg cacctttacc ctgtttaatc ttcctgcatt cgtcattgta atggcgatca 973441 catatttgct ttatttaggc atcaaagaat caaaaagagt caacaatatc atggttatct 973501 tgaagatact ggttgttctg ctgtttatcg cggtggcagc cgtttacgtg aagccgcaca 973561 actggcagcc gtttatgcca atgggctttg gcggcgtgtt cagtgcagcg gcgctcgtat 973621 tctttgcttt tatcggattt gacgctgtat cctctgctgc ggaagaaacg aaaaatcccg 973681 cgaaggatct gcctaaaggc attattttct ctttactggt ctgcacgatt ttatatgtca 973741 ccgtatcagc catcatgact ggggttatcc cgtttgctca atttgcgggt gtggatcatc 973801 cggtttctct tgttcttcaa agcgcagggc aaaattgggt ggcaggcatc attgatattg 973861 gcgccgtgtt gggaatgaca acagttatgc tcgtgatgct ttacgggcag acccgcgtca 973921 tgtttgccat gtcgcgtgac ggacttgtgc cgggttcact ttctaaagtg catccaaagc 973981 acaaaacacc ttatgtagcc acttggtttt tcggaacgat gtcggcgctt ctcggctcac 974041 ttgttccgct ggatgaactt gcaaagctgg tgaacatcgg gacgttgtcg gcatttgtcc 974101 tgatttctgt ggcagttatc gttttgagaa agaaacagcc tgatcttccg agagctttta 974161 aatgcccggg agttcccgtg atcccaggcc tggcgattct gttctgcctg ttcttgattt 974221 taaatctggg atgggtgacg attgtccgct tcctagtgtg gctgttaatc ggcttggtaa 974281 tctatttcct gtattcaaga aagcattcaa aattaaatca ataacctttt gataaagaga 974341 gcggccatac aggccgcctc ttttctgttc ttggcaaatg aatctataga aatgaagaca 974401 aaaataagag ataatatagg ctggaaagga agtgacgttt attgtctgag caaaaaccag 974461 tccaatgggc ttcgaaaatt ggtttcgtca tggcagcggc cggctcggct atcggcttgg 974521 gcgcgatttg gaagttccct tacgtagcgg ggaccaatgg gggaggagcc ttttttctta 974581 tcttcgtgtt atttaccatc ctcttaggct atccgctttt ggtgggggaa tttatttttg 974641 gaagacggaa ccagacgaat gccattgatg catataaaaa agaagcgccg cgatcagctt 974701 ggtttcttac ggggtggatc ggcgtagcgg cgtgtttctt agtgctgtcg ttttacagtg 974761 taatcggggg atggattttg ctgtatatcg tgaaaacagc gtcaggatca ctgtccgggc 974821 tttctcaagc acagtatggc gctctttttg cttctattat ccaaaatccg gtgcagacgc 974881 tcgcggctca gcttgtcttt atggcactga ctgtactcgt tgtcgcaaga ggggttcaaa 974941 aagggattga acgggtaagc gcggtgatga tgccgatttt gtttttattg tttattctgc 975001 tcgttcttcg gtctcttacg cttaatggtg caatggaagg cgtaaagttt ctgcttgtgc 975061 ctcatttcgg cgatctgact ccggaatcca tattattcgc gctgggacag gccttcttta 975121 cgttaacact gggggtttcg gtgatggtga cctacagctc ctatttgccg aaaacacaaa 975181 atatccctcg ttcggcagcc tccattgtct tgatgaatat cattgtgaca ctcttggcag 975241 gtttggctat ttttccggcg gttttctcat tcggttttca gccaaatgaa ggaccgacat 975301 tgctgtttac agtgcttccg gccgtttttg aacagcttcc gttcggcaca ttgtttttta 975361 tcggctttct cgttgcattt ttatttgcag ccttaacctc agcattttcg atggttgaaa 975421 ttatcgttgc cacaatcgga aaaggggacg aaaagaagag aaaaaaactg tcatggacga 975481 gcgggctttt gatctttttg gtcggaatcc catgctgctt gtcttatggc gttttgagtg 975541 atgtgcacct atttggcaaa acgttttttg atattgccga ttttaccgtc agcaatgttt 975601 tgatgccttc aggcgctctg ttaatttctc tatttatccc gctgaaaatt tcgaaaagcg 975661 aactcttggc tgaaatgcga aatggatcaa atgcaggtaa agcattcttt tacacatggt 975721 tttatttgct tcgttttatc gtgccgcttg ccattattat cgtgttctta aatttaatcg 975781 gaattttatc attttaaaaa acaggctccg tttccggggc ctgtttttta tttaataaga 975841 tgatatcaac ggtgcccatg ccgttttcag tttttggatg ccgagcctga tgtcctcttc 975901 tgacaaaccg ccataaccga ttaagacaga agtaaaaggc gtctgttcta tatatgaggg 975961 agacacggga tagagggtta caccgtggtc agcggctgct tgtattgctt cttcctcact 976021 tgctggaaac aaaaggcgca gcagaatgtg aagccccgag ttcttaccga gaatctcaac 976081 ggtgtttccc agttcagagc gaatggcttc taacaggaca gcgtgttttt ttcggtataa 976141 gcttctcatt ctatttatgt gtttttgcca ctctccggtt tcgatgaagt ctgccagtgc 976201 caattgcgag tgggcagaaa cggtctgctt cattaactga acattgtttt ggatcggttc 976261 catgagttca gggggcacaa tcatgaagct gagccgcaag gaaggcagaa gtgactttga 976321 aaaagtgccc agatatatga ctctgccatt cggatcaaga ccctgtaaag acggaatggg 976381 atggccgctg tagcgaaatt ctccatcgta atcatcttct ataatgaatg aatttgtttc 976441 tgccgcccat gccagcagct cctgtctgcg ggtaatcgtc ataatggtcc caatcggaaa 976501 ctgatgcgaa ggagtcgtat acatgagata aggattctga cggtagagct catccggcag 976561 gacgccttct gcatcagaac aaatcggagt gacatccatg tgatttgctt caaacatcct 976621 tcttgaacgg tgaaagcccg gttcttcaaa gccgattttt gtacctggct ttagcgaaag 976681 gcaaagattt tgcagaagca cggtggttcc tgcgccgatg ataatctggc cgggttcaca 976741 atttactccc cgagacagcc tgacgaatcg ggcaatcatg tgcctgagtt cgtattctcc 976801 ttgagggtcg ccagaggtgt gaaacgatcc ggaatagcga tcaagacttt ttactatgct 976861 ttttctccat gcgttaaagg gaaagagggt cggatcaacg ctgccctgat ggaagtcaat 976921 agcaggtgcg tttttttgat gtaatcccgg ctgtacagac tgctgaaaat ggtcaggagc 976981 tgtcgggaat cctggttcta cttccgccgc gaaccagccg attttcggct tgcttttgac 977041 atagccctca gcagttaatt gctcataagc tcgttctata gttgccgtgc tgacatcgag 977101 caagctggag agcctgcgtt ttgacggaag tcttgttccc tttgtgattc gcgcatgtga 977161 aatttcttgt ttaaaaaagg tataaagctg ttcatacagc ggtgttttgc tctttttatc 977221 aagaaacggc gtaatatcca tctcatgtct cctttgtagc tggcatggtc attttttctg 977281 atattggcta tttggcaaat gccatttatt agctatgatc attgtaacga aaggaaaggg 977341 gattgagaag atgatccata tgaaacaatt aacctcgaaa gaagaatggg ctgagtcgta 977401 tccgattatg agtgaattga gaacagaact ggatatagag acgtatttac aaaggcttga 977461 agcctgtgtg cagaaagaat cgtatatgct gtttgcctta tatgaaaata cagcaatcag 977521 agcgctgtgc ggggctctgc cgagagtttc cattcataaa ggagagcact tgtggattgc 977581 ggatcttgtt acaacggcac cttgccgatc aaagggatac ggcaaaatgc ttttggatta 977641 tgcctcagac tgggcgagaa aagccggact cggttttgtc agtctttcat ctggccttca 977701 gcgtaaagac gcacatcgat tttatacaga taaaatgggt tttactatag aaagttattt 977761 gttccgaaaa ccggtataac gaaaaaagac gcctgaaaag gcgtcttttt taaaagccaa 977821 actgtaaatt cgtatctaca gatacaatgg tatacacaca aataatcaca aagagattaa 977881 ggatgacgcc gagcaggcct ggacctgtgc gccctctctt gatgaagagt tcaacaacgc 977941 cgaacggaac ggcagccatg gcgaacggaa gcatttgata ggaataaaac gtgacgttgc 978001 tgataatggc caaattcagc aacagcaggg acagaaccgc tgtcccgaca gagatccagc 978061 cgaatacatt gtgttcttta aaaattctta ccagttccat aattccacct cgccgacatt 978121 cgctgatttt acagatttat ttttcagcat gcgctggatt tccttggttg gccctgtaac 978181 gaccgaaccg tatacattga caccgttttt ctctacataa tctaatcggt tatctacatt 978241 caggtctttc cgttttgaaa tgacctgagc ccatttttcg tgtttggaca tgaatttcag 978301 ggcgttgata aactgatcgc cattcgactt gccttttgta ttaagggcgg ccaagaactt 978361 tgaatccttt ccaggatagc caagaggttc tgtggaagct gtcttatttg tgtttttctc 978421 tgtttcgatt gcgttccaca aaaagctcac atcatagcct ttgaatttgt tatacacgtc 978481 ttttgtcgga tatgcacggt catatgaaag gtagacctct gataccgttc cttcaggcaa 978541 tgtgcttaac gttttttctg cttttgcggt cgtttgttca gacttgtttg aaggatgtgt 978601 aaagtaatgg ccggttttat tcacttctaa gtcatagtag tttactgccg gcgcttttac 978661 tttgttataa aacatttcaa cccgttcatt ccctacggca gccgtcttcg tgccaatctg 978721 cttttgcagc gggaattccg tattcattcc aaatagcttc acttggcttt tcagtccgga 978781 agtatcaaca agaacattcg gcatggtcag ggctacagtg actgcggcag tttccataaa 978841 ctcattgccg gtgctgtgtt ttccacccat tccgtaatag aggtagcttc ccagcgtaca 978901 aagcggcaaa atcatcaatg tcgaaatgac ggcaagcaca gaaattcgca aataagactt 978961 gcgtttgccg taggctaaaa tcgctttttg tttttcagga ctgatgctga gatcccaatc 979021 gttatcgtcc tctagttcgc tgtcaatcag ttcctgatat acttcaagct tctcgagttc 979081 ttcctcaaat gcagtcattt cctggtcgct catttcccca tttttatatt gatcaaaacg 979141 ctttttaaat tcttcattca tcattaacac ctctattata aagtgctttc agccgctgtc 979201 tggcacgaaa taaaacactt ttaaaattcg cctctgaaat attcataata tgggatgctt 979261 ctttgtagtt taactctttt aaataatata gcgttaaggc ctcccgataa ttatcgggga 979321 gctcggacat ataaccagtc agcacttcct ttatctctac ctgatgggca ggactttgaa 979381 cagcattttg aaagaggctt ccgattaagt catcagaaat ggttacttct ttcttatgct 979441 ttctgacgta atcaatgaag gcgtttcgcg ccacttgaaa aagccagggc tttactttgc 979501 tgtgatcata ggagtgaatg tgtatgtatg cccgcataaa ggtttcctgc agtaagtctt 979561 cagcaagatg cttgtctttt gtcatggaga gcaggaacct gtaaacatca ttcatgtaca 979621 tttggtaaat ttcatcgatc gtcactgcct tttctcccct ctatgttata cacgcataag 979681 aaaggtttaa agttgcacat tacatgcaaa cggctttttt atacctaatc aaacaccatt 979741 actatatagt acccaaaaat ggccgcaaaa gatagtgcgg agaaaggttt aacatttttt 979801 ccagagggga aaagatagtg aaaaagtgaa ggagtggcac aatggaatat accagtatag 979861 cagatacagg aatagaagcc tccagaatcg gcctcggcac atgggccatt ggcggaacga 979921 tgtggggagg cactgacgaa aaaacatcga ttgaaacaat ccgcgccgct cttgatcagg 979981 ggattacact gattgacacc gcaccggctt acggcttcgg gcagtccgag gaaattgtcg 980041 gaaaggcaat caaagagtac ggcaaaagag accaggtgat tctcgcaacg aaaacggctc 980101 tggactggaa gaacaaccag ctgttccgcc atgcgaacag agcgagaatt gtagaggaag 980161 ttgagaattc tttgaagcgg cttcaaacag actatattga tctttatcag gtgcattggc 980221 ccgatccgct tgtgccaatt gaagaaacgg ctgaagtcat gaaggaatta tatgatgcgg 980281 gaaaaatccg ggcgattggc gtcagcaatt tttcaattga gcaaatggat acatttcgcg 980341 ccgtcgcacc tctccatacg attcagcctc catataatct gtttgaaaga gagatggaag 980401 agagtgtcct tccttatgcg aaagataaca agataacaac attattatac ggcagtttat 980461 gcagagggct gttaacaggc aaaatgactg aagaatatac atttgagggc gatgatctgc 980521 gtaatcacga tccaaaattc cagaagcccc gctttaaaga gtatctttct gctgtgaatc 980581 aattggataa gctggcgaag acacgttatg gaaaatcagt gattcacttg gctgtcagat 980641 ggatcttaga tcagccggga gcggatatcg ctctttgggg agcaagaaag cctgggcagc 980701 ttgaggccct atctgagatt acaggctgga cgctgaacag tgaagatcag aaagatatca 980761 atactatatt ggaaaatacg atatcagacc ctgtcggacc ggagtttatg gccccgccga 980821 ccagagagga aatataacaa aagctgaggg cgaatcctca gctttttggc gtttaaacga 980881 gagaaatctt aaaaattagt accaggtaat aaaaaatatt gttataatag atgacagaaa 980941 gaatcattga ttacgacaaa ggaagtgcga tatgtataag ttttgtgcaa atgctttaaa 981001 agttattctt tctcttcgcg gaggagtgaa ggtgtataac aaagaaaacc ttccggccga 981061 ttcaggtttt gtcatcgcgt gtacacattc cggctgggtt gatgtgatta cactcggagt 981121 cgggattctt ccttatcaaa tacactacat ggcgaaaaaa gagctttttc aaaataaatg 981181 gatcggttcg tttctgaaga aaattcatgc ctttccggta gatcgggaaa atcccgggcc 981241 aagcagtatt aaaacgccga ttaagctgct gaaagaagga gagatcgtcg gtatcttccc 981301 aagcggaaca agaacctctg aggatgtgcc tttgaaaaga ggtgcggtga cgattgcgca 981361 aatggggaaa gcgccgcttg tccccgctgc atatcagggc ccttcaagcg gaaaagaatt 981421 attcaaaaaa ggaaaaatga agctgattat cggtgagcct cttcaccagg ctgattttgc 981481 ccacctgcct tcaaaggaaa gacttgcagc aatgacagag gctttgaatc agcggattaa 981541 agaactagag aataaacttg atcagctata aggcgttctg agagattgtc ctgaaactgt 981601 gaaaataaga aaagcaccct atacaaggtg cttttcttat tatgcttcct gctggttagc 981661 tgtctccaga agttcttctt cttgaagctt tttcacttca atatatgcga cgtggtggcc 981721 gtcaatttca ttaatgatga attcgcagcc ctcttcgatg atggaatcat ctttttcaac 981781 atcgtatttt tgagtaagga accagccgcc gattgtatcg acttcttcgt tctctaaatg 981841 gatgcctagc aggtcgttta cttggtcaat taacactttt ccgtcaagaa tataatggcc 981901 ttcgccgatt ttgcggattt cgctaatttc atcaatatca aattcgtcgc ggatttcacc 981961 gacaatttcc tcaatgatgt cctcaaccgt cacaagcccg gcagtaccgc cgtattcatc 982021 agacaaaatg gccatgtgga ccctctcttt ttgcattttg acaagcaggt cttggatcgg 982081 cgcagattca atgacatgaa tgatagggtt gacgaattga gaaatggtgg aatcaacaga 982141 tacctcaccg ctgatgcagg cggtcagcac ttctttaatg ttaataaccc cgataatgtt 982201 atctttatcg ccctcttcca cagggtagcg ggtatatttt tcaatctgaa tgatgtccat 982261 catttcagaa atcttgatat catgcggaag gctgacaatt tcggtccgcg gaatcataat 982321 ttctttcgcg agcctgtcgt caaattcaaa gattttattc acatatttaa actctgattg 982381 gttgatttca ccgcttttat agctttcaga caaaatgatt cgcagctctt cttctgagtg 982441 agccagttcg ttttctgaaa cggtctccag gccaaatgct ttggtcaata accgtgcgga 982501 attgttcaaa agccaaatga atgggaacgc gatgcggtaa aaccaaatca gcggtttcgc 982561 aaacagcata gacactgctt ccgccttttg gatagcgact gttttaggtg caagttctcc 982621 gacaacaacg tgtaagaacg tgataatggc atacgcaaaa ataaacgata tgacatgtga 982681 aagggaacct ggaacgttca tttggacgaa aagcgggtga agcagccttt cgatcgttga 982741 ttcacctaaa acccctaatc cgatggaagt caatgtaatt ccgagctgac acgcagataa 982801 atattcatca agatgcgtgg tcactttttt tacggctatt gctgctttat ttccttccgc 982861 gatcagctga tcgatccgtg agcctctgat tctgataatg gcaaactcag atgccacgaa 982921 aaatgccgtc agggcgatta aaacagcaac taaaatcaaa ttcactatgt ccaattagaa 982981 ccttcactct agcaatgaga atgaaggtaa cacctcctgt tagataaaat ggttttaact 983041 taacagcagc ataaatgatt ggaacacggc gagcttttca ggcgggagtt tgcttttcag 983101 cttgtcacga tcctcgggct tcagccgttc aaaccgatgc aagattccgg agatgttttg 983161 attcatatga tcaatttcta atgccagatt tccaatttca tcatcaagtt tagctgaaga 983221 gggaaactgg ttctccagtc gatctttaat atcggacagg gccaatcgct gcttcttgca 983281 atctacaata aatataagtc gtttgagtgc attttcgtcg tagtaacggt aatttgaaca 983341 ggatctggcc ggcgtaagca gaccgagatt cgtataataa tcaactgtcc gtttcgttac 983401 tccggcgagt gccgctagtt cactgatgcg ataagtctca gccccatcta tatccctccc 983461 aaccatcacg ttatagttat gagaatagtt taatatatga acggtgtctt gcacaagttt 983521 attgtttttt ttagaccgga attggaagtt gtggaattca tcatctgatt gaagtaacat 983581 aggaagatag aattttcaaa tttttatatg cggaagggac agatgaaatt ggctgggtta 983641 tcccgggaag ttgaagaaaa cttaaataaa ggatcatgga ttcgcaagct gtttgatgaa 983701 ggtgcaaggc tgaagaagga gttcggggaa gaccaggtat ttgatttttc actcggcaac 983761 ccgattgttg aaccgcctga agcttttaag agagcgttaa tagaggaagc tgaaaaaggc 983821 agccacggat acatacaaaa ccaagggctt cttgcagcga gagaaaaagt cgcgcaattt 983881 ctgggctcgc gttttgaagc tgatttctca gcggagcgca tcgtcatgac ggtgggcgcg 983941 ggaggcgctt tgaatgttgc gttaaaaagc atcgtaaacc ctggggaaga ggtcattatt 984001 cttgcacctt attttgccga atataagttg tatattgaga actacggggg aaaagccgtc 984061 agctgcccgt tgacaagccg gtttgagatc gacattgaag cggtaaggca atcgatcact 984121 ccacagacga aagggctgat tctcaataca ccgcataacc ccacaggcac tgttctcagc 984181 cagaaaaata tagacgattt aggcgcttta ttaaaagaaa tagaagagaa gagcggccag 984241 acgatttatg tgctgtttga tgaaccgtac agtcaattaa tctatgatga agagctggca 984301 aatccgtttc aatcgtacca tcgtgtgata ttggccagct cattcagtaa agatctcggc 984361 atagccggag agcggctcgg gtatatcgga ttggacagcc gaatgccgga tgcggacctt 984421 ttgatcaacg cttttgtgta ttgtaatcga acgcttggat ttgtgaatgc ccctgtcatg 984481 atgcagcggg ctgtggcacg aatggatgat ttaagagtag acgcgagcgc ttataaagag 984541 cgccgggatt taatggtaga cattttaaaa gaagccggtt ttgaatttga aatgccaaag 984601 ggaggtttct ttgtttttcc gaaatcgccg attgaagatg aagttgcatt ttgcgtgcat 984661 gccgcccaaa aatacaaatt attaattgtg ccgagcagcg gttttggaat gagcgggcat 984721 ttccgattat ccttcagtgt gccgatcgag cagattaaaa actcacggga cattttcatt 984781 tctttatata aagattttgc ttaagaaggc aaagaaaaga aaacagtttt caaggctgtt 984841 ttctttttat atccgcaaaa tccttcctct tccaatccag acaggcgcag aattgacaag 984901 caggcatgca gttaaggctt tcttcatgat aaaagtctaa aaattaaaaa tcatttttgg 984961 aatgagttgt gttacaataa aatatacaat ttataatcaa actttgactt ttggaggtgg 985021 tatgatgggg ccctctgctt aggcaacaat acaccgcgta cctcaatgtt aaggaaaaat 985081 gattatatca ggaggtgact ccttatcctt tgttgagagg atagggttaa atggacgata 985141 ttgacagtct gattttaatt ggcgtgctca ttgctttaac cgcgtttttc gttgcaagcg 985201 agtttgcgat tgttagagtg aggagatcca gaatagatca gcttatcaca gaaggaaaca 985261 aacgggcgat actcgcaagg cgtgtcatta cagatttgga tgaatattta tccgcatccc 985321 agctaggcat tacattgaca tcaatcgggc ttggcgtact gggtgagccg gcctttgaac 985381 ggctgctgca tccactgttt gaaccgctcg gcttgccgga ctcggtttca catgcagtct 985441 cttttgcagt cgcgtacggc ttgatcacgt tcctgcacgt tgttgtaggt gaactggccc 985501 cgaaaacggt cgcgattcaa aaggcagaac agctgacttt actgatagcg ggccctttgc 985561 gtttattcta tttgctcctg tttccgttta tttggatcct caatggatcg gcgcggcttt 985621 tatgcgggat gttcggtttg aagcctgcgt cagaacatga tggttcccat tctgaggaag 985681 aactcaggat gctgttatct gagagtttaa aaaacggaga gattaatccg tctgaatata 985741 aatatgtgaa taagattttt gaatttgata atcggatcgc caaagaaatt atgataccgc 985801 ggaaggaaat ggctgctgtg tcaactgaga tgacgatggc cgagatgctt gaagtcatgc 985861 tgaaggaaaa atacacgcgc tggccagtca cagatggaga caaagacagt gtgctcggtt 985921 tggtcaatac gaagcatttg ttttctgatt tgctgtttat gacagaagaa gaacgaatga 985981 agatgacgat ccatccgtat gtgaggccgg tcatcgaagt gattgaaacg atcccggttc 986041 atgacttgct gattaaaatg cagcgcgagc gcattcatat ggctatattg tcggatgaat 986101 acggaggaac ctcgggactt gtgacgacag aggatattct tgaggaaatt gtcggagaga 986161 tccgagatga atttgatgaa gatgaacagc cgctgatcca aaagcttggc gacggccatt 986221 atgtgatgga tggaaaggtt cggatcgatc aggtgaacag ccttcttggc gcatcgattc 986281 aagaagacgt cgatacgatc ggcgggctga tattaaaaga aaacatcgat attgaggctg 986341 gtgaatccat tcgcatcggt tcatatacga taaaggtgct gaagatggac ggccgattaa 986401 tcaagcaaat cgatataaaa gaagaagccg gcaacacaac cgggattacg gcgcaccaca 986461 agctgccgct gcccgagcct gtgatgctga acagtgcaac cttgagcgag aaataagctc 986521 aaggtttttt tatattgtga ttgtccagcc gcaccaaaat gcaaaaagcg acccgcaaag 986581 tgtcaggacg atgtacaaga tgctttcttt tacacgtttg gccataagga gttgaatagt 986641 ttcaacgctg aatgtggaaa aggtcgtaaa ggcgccaaaa aaccccgtgc caatgataag 986701 cgagaccgaa gcatttgcaa cgtgaagtcc tgtaaatatt ccgagcccga gagctccgag 986761 aatattgact gtcagtatgc caatgggcag gctgagacct ttggttttgg cggttatgac 986821 attgccaagc cagaagcgaa gcattgcgcc aagtccgccc cctatgaaaa tacccgctag 986881 tgtcattttt cctgcagccc ctttctttgc tgaatgcctg ctatgcgccg tcccacaaaa 986941 acaccaatca gtgcaaatat gatccctgat atcaatgagg ctgccacata taaaagagcc 987001 aatgagggtt gtccttgcaa aagcatcact gtttccttag aaaacgtgga cattgttgtg 987061 aagcctccgc aaaagccggt gcctaaaaaa gccgacagca gaggccgttt tgccccgatc 987121 ataaaaaatc cggtcaaaat gcctaataga aggctgcctg ccgcattttc cagccaggtt 987181 gccgccggga actgaccggt gtgtatccat aagtttaatc cgtatcggag gcaggcgcca 987241 agcgcgcctc cgataaaaac cgcgctatat attttcatgt ttgccatcct ttatgatgaa 987301 atccgggtaa tctgtaacga tgccgtccac gcccatggct tgtaattttg ccgctgtctt 987361 ttgattgttg acagtccatg caaatatgtt taagccattt ttattgatgg agccgatcat 987421 cagacggtta agccgtgtgt gttttatatt gacatagttt gcaaaagagc ggaaggcctt 987481 catctgattt ctggacagca tgccaaagtt gggccttgta atgaccgctg tcggaatcga 987541 aggataaagc tcgcggaacc tttggacgga gcggaactga aaggattgaa caatattatt 987601 gatagaaaaa gaaaattgcc ctaatagctg tcccacctct tcttcaattc cgacttgaga 987661 cggatggcct tttagttcaa ttaaaaggcc gatttttttg tggtagcgct tgagcaccgc 987721 ttccagggtt ggaatacgct ctccttgaaa agcgggaccg taccagcttc ctgcatcgag 987781 tttttgcaat tcctccaagg taaaatcctt aacaaagccc gatccgtttg ttgttcggtc 987841 aaccctgtca tcgtgtatca caacaatctg cctgtctttt gtaagctgga catccagttc 987901 gatcatatct gcattcattt tcaccgcaag gtcaaatgcg gcaatcgtat tttccggagc 987961 gtagccggat gctccgcgat gggcaatgat gtacaagcta agtcagctcc tcgtatgggc 988021 atttctgtta ttgtatcaaa tccatatatg caccgcgata caaactggtg aattttttct 988081 gccatatcgg aatggtccgg gctgaggaat gcgtataact aaaaaaagac actcagcgta 988141 tcagaacaca tttcgtcaga aaattaggtc tttcgacatg ttcacaacaa aatatgatcc 988201 tttataatag caaaaaagga ggcgagatca tgggaaaagg gagaatcaga gtggaggaaa 988261 gaattaaagc cgaaacggat gctgaaatgc aaaaagcaac tctccttgat cagacacaaa 988321 cgaaaaaagg taagtgactg tccctattga atctggctga tagatgaatt gagaaatgac 988381 cccggcgttt cgccggggtt ttgtgctgca taagacattt aaatgaacat ccttacgaat 988441 attttagtat aataaacaat tgattgggat agaggggaga cagtcatgcc ggattatctg 988501 cagcagtatt ttacgcttga taacatcata caaatcggca tcagcttggc gattttgctg 988561 gtgtttctta tacttagaaa attattcaca agatattttt ttaacctgct ttttaatttg 988621 acaaaccggc cgaaaacaga aatttttaaa caggtggttc tggcgtttga taagccggcc 988681 agatggtttt ttgttgccct tgggctgttt ttagcgatcc ggtattcacc gtttttagat 988741 gagcaaatgc cggtcatcag caaaatatac cgctcactga ttgtggcgct cttgtgttgg 988801 ggtctttgta atttgaccgc aacatcgtcg tttatcttcc ataaggtgaa ccagcgcttc 988861 gagcttgaca tggatgacat tctggccccg tttttatcca aattgctccg ttttgtgatc 988921 attgcgctca gtgtcagtgt gatcgctcag gaattcaatt atgatgtcaa cggatttgta 988981 gcgggccttg gtcttggcgg actggctttt gcgcttgccg cgaaggatac catcagcaac 989041 ttcttcggcg gtattatcat tattactgaa aagccgttta caattggtga ctgggtggag 989101 acgtcgacag taacaggatc agtcgaggat attaccttta ggagcacgag attcagaaca 989161 gcacaggggg cgcttgtaac ggtgccgaac tctacgctgt cgatggaagc gatcacgaac 989221 tggacaagaa tgaccaaacg ccagattacg ttttccatcc atgtgtccta cgctacgccg 989281 attgagaacc ttgaacgctc cattcattct ctcagaacaa tgctcttaga gcatgagggc 989341 gttgataatg aaataatcat ggtcaacttt gatacgtttg ccgacagcta ctacaattta 989401 ttttttaact tctatacaaa aacgacggtt tgggctgaaa accttaatat tagagaggat 989461 atcaactata aaattattga gattttaggt gcagaaggcg ttcagtttgc atatcccggc 989521 caaatggttg ttgtcaagca aaagcacgaa agcgaccaat tccaggtgaa tctaaataaa 989581 gaggaaaagg aacgggctta aaagagagac ttcgtctgac agaggcggag tctttttcat 989641 ggtaaaataa gagaaaaagg cggtgttgag ttggaaacat tcaaaagtat tctacatgaa 989701 gcacagagaa ttgttgtgct gaccggagcg ggaatgagca cagaatcagg gatccccgac 989761 tttcgttcag cagggggcat ttggacggag gatgcctcaa gaatggaagc gatgagcctt 989821 gattattttt taagttatcc gcgtctgttt tggcccaaat tcaaagaatt gttccagatg 989881 aaaatgagcg gcagctttga accgaatgaa ggccatttgc ttttagctga gctggagaag 989941 caagggaagc aggtcgatat tttcacgcaa aacattgacg gtcttcataa aaaagcgggg 990001 agcaggcatg tgtacgaact gcatggttct atccagacag cagcttgtcc ggcatgcggc 990061 gcccgatatg atcttcccca tttgctggag cgggaggtgc cggagtgcac ggcggccgga 990121 aacaatgggg acatttgcgg aacggtatta aaaaccgatg ttgttctctt tggcgatgcc 990181 gtcatgcact ttgacaccct ttatgaaaag ctggatcaag cagatctttt attggttatc 990241 ggcacgtctc tcgaagtggc tccggctaga tttgtgcctg aggatgcaag cctgattccc 990301 ggcatgaaga aagtcatcat aaaccttgaa ccaacgtatt gcgacagctt gtttgacatg 990361 gtcatccatc aaaaaatcgg cgagtttgcc cgaagtttgg gcatgaaaaa gtgagccgct 990421 ttatgcgcct cactttttta ttcatgaaca ggaaccattg tgtcctctaa cactccgaag 990481 gaatagcctt tttcttttaa tttattgatt agtaccggca gcgcatttac agtagcagga 990541 agatcatgca tgagaattac atttgggcgg cttgaagagc tgtgttccat attctcaagc 990601 tgctgtaata cggcggtcac atactgtgaa ttccggtatt tccagtccat gctgtcgatc 990661 gtccaatccc agtacacaaa cccatctttc tccagattgc gaatttgtga ggcggttagt 990721 gacggcttgc ttccgtatgg cgttctgaca agatcggttt tatatcctgt aatgtcctgc 990781 agcgtgtcac gcgcctcctg catttctttt agcggagatg tcggtgtttg atagaacaat 990841 ctgttattgt gggtaacgcc atgtaaaccg agtgcgtggc cttccttttc tgctcttttc 990901 acagcctgct tgaattcgtt catccgcggt gacagcataa aaaacgtcgc ttttacatca 990961 gcgcttttca gtacgtcgag caagcgggtt gtaacggctg aagggccgtc gtcgaaggtt 991021 aagtaaaccg ttttatctcc catgttctgc tttgtctgca gatgttttat caggagatcg 991081 ggggagtcgt ttttcagctt aaggctttcc ttctcatctc gaagctggcc gtttgttgtg 991141 acagtgactt cctttgcttt cgttgaactg ttggaataac ccaaaatcac cataagcaaa 991201 agcagcacac ataaaactgc taaacttgca aatttaaaag caagcgaaac tgcagaagga 991261 gaagcctctc ctctcgtttg tcgcataaca atctctccat tggcataaaa tctctacata 991321 atgctgtaca gcaggcagct tatgaagatg ccttatgttt acaacctatg tattaccagt 991381 caagtataca ggaataaaac tggaaagcac atagaaaatt tgtcgaaatg tcagatttta 991441 aggaaaaaat aaactccttt ccgctataga tctcttgatc tttctgtttt tcagcttgtc 991501 caatatggta gaattagtga taatgacagc ttgaatgaca tcagggacat ctcgaaaagg 991561 gagggctttt atgaaggttt tagtcaatgg ccggctgatt gggcgcagtg aagcatcaat 991621 cgatttggaa gatcgcggtt atcagtttgg tgacggcatc tatgaagtga tcagggtgta 991681 caaaggagta ttgttcggct tacgtgagca tgcagagcgt tttttcagaa gtgctgctga 991741 aatcggaatt tcactgccat tcagtataga agatctcgag tgggacctgc aaaagcttgt 991801 acaggaaaat gcggtcagtg agggagcggt atacattcag acaacaagag gtgtggcccc 991861 gcgaaaacac cagtatgaag ccggcctcga gccgcagact actgcctata cgtttacggt 991921 gaaaaaaccg gagcaagagc aggcatacgg agtggcggcc attacagatg aggatcttcg 991981 ctggttaaga tgtgatatca aaagtctgaa tttactgtat aatgtcatga cgaagcaaag 992041 ggcctatgaa gccggagcat ttgaagccat tttacttagg gacggcgttg ttacggaggg 992101 tacatcctct aacgtttatg ccgttatcaa cggcacagtg cgaacacatc cggctaatcg 992161 gctcattctc aatggaatta cacggatgaa tattttagga ctgattgaga agaatgggat 992221 caaactggat gagactcctg tcagtgaaga agagttgaaa caggcggaag agatctttat 992281 ttcgtcaacg acggcagaaa ttattccggt cgtgacgctc gatggacaat cgatcggaag 992341 cgggaaaccc ggaccggtga ccaaacagct tcaggctgct tttcaagaaa gcattcaaca 992401 ggctgctagc atttcataaa tgaacgaaga aaagagcccg ctttttacag cggggctctt 992461 tttatttttt aacaaatcca atcaaaatgg agatcattgg cgatatatag aggaagaacg 992521 taaatgggat gtagtctatg actggaacac caagtgcgct cgccataaat gcgccgctga 992581 cgccccaagg aatcaatggg ttaattaatg ttccgccgtc ctctaatgat cttgtcagaa 992641 attttcgctg gatgtttcgt ttgtcatata aagatttaaa tgattgtccc ggtattaata 992701 tcgataaata ctgttcgccc gttgccaagt tgacgccgat gcttgagcag acagttgctg 992761 caacaagacg gccttttgag cggatgcctt tcatgacgcc ttccaatagt gcagaaatca 992821 atccgatttt ctccatcaat ccgccgagtg caaaagcaat cataatgaga gagacagagc 992881 ccatcatgga ttgcagtccg cctctgttaa taattttagc ggctgcctca ttgtcagttt 992941 cgaaagttgt gccattttgt aaagctgtca taaacgcctg caggctgctg tagggtacaa 993001 aaatagcagt caaaattccc gaggaaataa ttccggcagt cagaacgggg attactgata 993061 cccgtttcat tgccagcaaa acgactaaga gcggagaaag aagggcccac ggtgtcacgt 993121 ttgcagcatc ttttattccg gttatgacct gctgaatatt atcggttgaa gcagcgtccg 993181 ctgacactga tgaaccgaga aagtaaaaca gaacgacagt gatgagcaaa gctggaatgg 993241 ttgtgcccat catatggcga atgtgttcaa agattggtat ttcgcctatt ccggctgcaa 993301 agttggttgt gtccgacatc ggcgacattt tatccccaaa acaagcgccg catatgactg 993361 cgcctgctgt ccattcaagc ggaacgccag ccgcgctcgc cacgccgatc agcgctactc 993421 cgattgtgct tacagttgtc agacttgagc caacaagtgt gctgatgatc atacatgaaa 993481 acaaagcagt caacagaagg tggcttggtt caataaagga tagggcataa actgtcatag 993541 tcggtattgc gccgctgtac atccaggcgc cgattaagat gccgatcagc gctagaacaa 993601 taatcggctg tacgccgttt ttgatcccgt ctacaatccc tttttcaatg ctcttccagg 993661 gaaatccaaa ccataaagct gctgctgaaa gcatgacaac acttaaaaac agcgggatat 993721 gaggttctac atgaagcaag aataagcaag aaataataat gcacaacatg aatataaata 993781 aaccgacggc taacggaaac gtcagctttt tttgagaatc caaaataaca ccccatattt 993841 atctttaatg cttttgtgct tttgggcacg aaagcattat aacagaaaaa aacgaaaatc 993901 tatgtttttt cacaattatg aatataaaag aagtgagcac agggcgtgct cactttacaa 993961 tcaggacggg tatatccgat ttcgctgaaa gcttttcact tacacttccg aatattagct 994021 ttttcagcct gttttggtct ctgcttccgg ttacgatcat atcggcagaa atgcggtttg 994081 catgctcgat aattgattca gccggatcgc cttctaatat atcgatatct ccatctgcct 994141 gctgttcatt cagcatcatt ctggcttcgg cgatgacttc ttccgtacgg tcttcataga 994201 tcattggctc aggtgatgtt acatccgata tcagcggatc aggaacactt gtcatgcctc 994261 cgctgatata gcttgcctca gctgcgggtc tgggcgggtc gatgacggtc tgattgtctt 994321 tcatatcatg tgaatgggcg acggtaatag cggcatttac ggttttagca agatcaatgg 994381 ctgtcagaag cgctttctta ctattttcac ttccgtcaaa cgcaacaatg atacggtcag 994441 catggaacat ccttctcacc ctttcaaagc gtcttacaac actactaccc gaatttgagc 994501 acaattaacc ttttcctatt caagtaatga ttgacaataa aaggttttgt ttatatgatg 994561 ataaaaagat gaaatcagaa tggaaggagg gtttgctatg ccaaggaatt tgcgtgttta 994621 tcaaacagtt tcatattggc gcggcaaacc ttttgttctg ttttcgtgaa cggtttttta 994681 ggtcggaccg cgcgctgaaa agcgctgtgc gtaacatatc ggttaaaaaa ggcatggagc 994741 tgacgcttca tgcctttttt atatacaaaa tctaaggaaa gacaggtgta tgggatgtga 994801 agacaaatac agaggcgagg gcagttcgtg ccaaactgga tgaaaaaagc tgcaaggaaa 994861 aaatagaagg cggctgatga ggagatgggg atagatgttt tcagttttga aaaagcttgg 994921 ctggtttttt aaggcgtact ggctgcgcta tacgattgcg attgtccttt tattagcagt 994981 caatgtcatt gaaatgtttc cgcctaagct cttggggaac gccatagatg atatgaaagc 995041 aggggcattt actgcggaag ggctgctgtt ttatatcggt atcttttttg tgctgacggc 995101 ggccgtgtat atcatgtctt atttttggat gcatcagctg tttggcggag cgaatctgat 995161 ggagaaaatt cttcgtacga agctgatggg gcatttgctg actatgtcgc cgccgtttta 995221 tgaaaaaaac cgaacaggcg atttaatggc acgagggaca aatgatcttc aggccgtcag 995281 tttaaccaca gggtttggca tcttgacgtt agttgattct acgatgttta tgatgacgat 995341 ctttttgaca atggggtttt tgatcagctg gaagctgacc tttgccgcca ttatcccgct 995401 tccagtcatg gcgattgcaa tcagtctata tggaagtaaa attcatgagc ggtttactga 995461 ggcccaaaac gcgttcgggg cgctgaatga cagagtgctg gaatctgttt caggcgtgcg 995521 ggtgattcgc gcgtatgttc aggaaacaaa cgatgttcgc cggtttaatg aaatgaccgc 995581 tgatgtttat cagaaaaata tgaaagtggc ttttattgat tcactgtttg agccgacggt 995641 aaaactgctt gtcggcgcaa gctatctgat tgggctcggc tacggagcgt ttcttgtatt 995701 ccggaacgag ctgacgcttg gagagttagt gtcctttaac gtttatctcg gcatgatgat 995761 ttggccgatg tttgcaatcg gtgaactcat taatgtgatg cagcgcggca atgcgtcatt 995821 agatcgggta aatgaaactc tttcttatga aacggatgtg acagatccaa aacagcccgc 995881 tgatcttaaa gagcctggag atatcgtttt cagtcatgtc agctttacat atccaagctc 995941 aacaagtgac aatcttcagg atatttcatt tacggtgcga aaagggcaga ctgtcgggat 996001 tgcaggtaaa accgggagcg gaaaaacgac aattattaag cagcttttgc gccagtatcc 996061 tccaggtgaa gggagcatta cattttcagg tgtaccgatt cagcaaatcc ctcttgaccg 996121 tctccgcgga tggatcggat atgtgcctca ggatcattta ctgttttcac ggactgtaaa 996181 agaaaatatt ttatacggaa aacaggatgc aactgataaa gaggttcagc aagccattgc 996241 cgaagcacat tttgaaaaag atttgcacat gcttccgtcc ggtctggaga caatggtcgg 996301 tgaaaaaggc gtggcactgt caggcgggca gaaacaaaga atttcgatcg cgagagcact 996361 catggcgaat ccggaaatct tgattctgga tgattcactt tccgctgtag atgccaaaac 996421 agaggctgca attatcaaga acatcagaga aaaccgcaaa ggaaaaacga catttatttt 996481 gacacaccga ttatccgcgg tagagcacgc tgacctgatc cttgtgatgg acggcggcgt 996541 cattgctgag agaggcacgc atcaagaact gctggccaat aatgggtggt accgggaaca 996601 atatgaaaga cagcagctgt tcactgcgga agaaggggga gcaggggcat gaaaatagga 996661 aaaacgttat ggagatacgc acttctttat cgaaaattgc tgatcacagc cgtccttttg 996721 ctaactgttg ccgtcggtgc agaactgact gggcccttta ttggcaaaaa aatgatagac 996781 gaccatatcc tcggcattga gaaaacatgg tatgaagctg cggaaaaaga taaaaatgcc 996841 gttcagtttc acggcgtctc atatgtcaga gaggaccgat tgcaggagcc tgtttcaaaa 996901 gcaaaagaag cgcatattta tcaagtggga atggcgttct attttgttga tcaggctgtc 996961 agcttcgacg ggaatagaac ggtttctgac gggaagctga cgatcacaaa cggagacaag 997021 agccgggcat atgctgccga aaagctgact aagcaggaac ttttccagtt ctatcagccg 997081 gaaataaagg gaatggtgtt actgatctgc ctgtatgggg gcttgcttgt gttttcggta 997141 ttctttcaat acggacagca ttatctgctg cagatgagcg ccaatcggat tattcaaaag 997201 atgaggcagg acgtgttttc gcacatacag aaaatgccga ttcgctattt tgacaacctt 997261 ccggccggaa aagtcgttgc gcggattacc aatgatacgg aggctattag ggatttatat 997321 gtcacagtgc tttcaacatt tgtgacaagc ggaatctata tgttcgggat attcacggct 997381 ttgtttctgc ttgatgtgaa gcttgcgttt gtatgtctgg caattgtgcc gattatctgg 997441 ctgtggtcgg tcatataccg gagatatgcg tcatattaca accaaaaaat ccgctcgatc 997501 aacagtgaca ttaacgcaaa aatgaatgag tcaattcaag gcatgaccat tattcaggct 997561 ttccgccatc aaaaggaaac aatgagagaa tttgaggaat taaatgaatc acatttttat 997621 ttccaaaaca ggatgctgaa tttaaactcc ttaatgtccc ataatctggt caatgtcatc 997681 cgcaatcttg cgttcgtctg tctgatctgg cattttggcg gtgcgagcct gaatgcggcg 997741 gggattgttt ctatcggtgt gctgtacgcg tttgtcgatt atttgaaccg gttatttcag 997801 ccgatcacag gcatcgtcaa tcagttttca aagctggagc ttgcaagggt ctccgccggg 997861 cgtgtttttg aactgcttga agaaaagaat acggaagaag cgggtgaacc ggcgaaggag 997921 cgcgcgctgg ggcgggttga atttcgtgat gtgtcatttg cgtatcaaga aggtgaagag 997981 gtattaaagc atatttcctt tactgcgcaa aaaggcgaaa ccgtagcgct cgtcggccat 998041 accggatcag gaaaaagctc gattttgaat cttctgtttc gtttttatga tgcgcaaaaa 998101 ggtgatgtct taattgatgg aaaaagcatt tacaacatgt caagacagga actcagatcc 998161 catatgggta ttgtgcttca ggacccgtac ttattctcgg gcacaatcgg atctaacgta 998221 agtctggatg acgaaagaat gactgaagaa gaaataaaaa atgcactgcg gcaagtcggt 998281 gctgagcctc ttcttaagaa gcttccgaag ggcattaatg agcccgtgat tgaaaaaggc 998341 agcacgctat cctctggaga gcggcagtta atttctttcg ctagagcttt ggcgtttgat 998401 cccgcgatct tgattttaga tgaggcaacg gcgcatattg atacagagac agaggccgtg 998461 atccagaagg cgcttgatgt cgtcaaacaa ggacgcacca ccttcgtcat cgctcaccgg 998521 ctttcaacaa tcagaaatgc tgatcagatt ttggttcttg ataaaggaga aattgttgag 998581 agagggaacc acgaggaact gatggcatta gaaggccaat attatcaaat gtatgaactg 998641 caaaagggac agaaacattc cattgcataa cgctcaaaaa cccaaaacaa tcgtgttttg 998701 ggtttttggt ttatgtagtc aataagccag tccgacacgg tttccgacat actcacctgt 998761 aacgagctca cgatataaaa agtccgcagt atcgccgacc gaaatgcttg tgccgccctc 998821 aggcaaaacg ttacgctccg tacgataaac gccggttgct gttccgtccg ggaggtaagt 998881 ggggcagatg attgtccagt ctaatgatga ttctttaagc atttcgtata cttttgcatg 998941 ctccttggct gcgcgggtct gctttcgttt cgattcattt gtttcaaacc ggtattttcc 999001 cggttcatat cgggaatcta ggatccctgc ggtgccgatc gtaataagcc gtttgatatg 999061 ctgttcctcc ataacggaga gaatgtgtgc catagcagtt gacaaggtat catcaccatc 999121 tgtgcctaga cagctgatca cgatttcagc attctccatt atttttttca catcttctaa 999181 gcggcgggcg ttccccatga cagttctgtc ttttgaaagg ggaagatcag catgttgaga 999241 tctgatcaga gcgaaaatat caaatctttc atctgctgca gcttgtgtta aaaaggcttg 999301 tccgacgcgg ccgctggctc ctaataaagc gattttcatt aaaaaacctc ctcgcctttc 999361 attataaaag gatgttctca gtttgaacag cgcgggaaag aatacctgta caaataaaca 999421 gaacgatggg aaacatattc atgaatcatg gatacactta cgaattgaac cagctcccaa 999481 ttcacaatgg tgatgaatga caccccgatt ccctcccttt ttttctagga tatgtggagc 999541 aggaaaaaag ggtgacaaaa taaagagagc gcggaaaccg cgccctctat agccatatat 999601 tgaattgtta ttgaactctg ccgcccattt gctgctgagc gaaagatact aaacgttttg 999661 tgatttctcc tccgacagaa ccgttagcgc gagaagttgt gtccgctcca aggttaacgc 999721 cgaattcaga agcgatttca agtttcattt gatcgatagc ctgagctgcg ccaggaacta 999781 gtaagtcatt tgaagagttt tggttagcca tgtgtaaaat ctccttttta tttagtatgg 999841 ttgggttaac tggagttgca ccaatctgtg aacccttctc gggtgtcact gccgcctcgg 999901 cgtaacccaa tgctttgccg gcttgttact acgtattatg ttaaaatggc cggaaaatca 999961 tgcggagaat tgtgtggtaa atcttgagaa ataaaaaaag cttagccgtt taggctaagc 1000021 tagtcataaa tatgaaaaag catcagttca tgtatctcgt ttgtaagagc aggctcgtca 1000081 gcgcgggcgg gaaacaagtc tccccattca atctcaccgc tcttatgata gatgccttca 1000141 taatgggtcc ctttataata aaatgaaatt ttccatccgg gcagcttttc ttttgggaac 1000201 aaaggtttcc agctgaaatg agaaatcatt acggccacgc tccttacatt tggtatcaat 1000261 tgacctaaat aaaaacggct tatgttcatt gtatcattgt ttcagaacat cattgaagag 1000321 gcctaaatat gcagtttgtc ccagctttgg ataaagataa gcccgcttta ttaaaaaagc 1000381 ggacaggtta cgaaggccac aatgcttccg gagatgtgat tgccttctca gataaatatg 1000441 acgcgtattc aaaacttctt cgttttgtaa gagaatcaac atgatgcaaa tttggatgag 1000501 aaaaaatgct tcggcccggg cgcgaattcg cttcaaacat ccatacttta ccgttctgat 1000561 caatgccaaa atcgaaacca atctccccga taaatccctc gatatgatca tgaaggacat 1000621 ggcttgcagt cagtgccgct gcagaaagct ttttaatgac ctcaactctt tcagcgggat 1000681 catcgtatac ttccgcaagt gtctttacag tgccgccgtt agaaagatgt gttgtaatgc 1000741 tgttctttcc ggaaattttt acggcgattg ctgtcactgt ccattttcct tttctgtttt 1000801 tattggtatg gacacggaaa tccgctggtt tgccttgaaa ttcgatgaga tcaacacctt 1000861 gctgaatgag aaagtcggac gggttgtgat gtttttgaaa ttctgcaagg aatgaggcgg 1000921 catcggaata atcaattgat gtaaaagttt tggcgtcatt cgtatgcttt accgtcaggc 1000981 cgccatctgt tcttgtcagc tgataaatgc cggtgccgag tgctccattt gccggtttga 1001041 tatagacttt tttgtatgcg ccacagagct catctatcag ctccacagac ggtgtcagct 1001101 cggatctagg caaaaagggt gccgttcttg gatctttttc gagcaattga tgaacgttcc 1001161 atttattgaa aaacgtttta ttaaaccatg ggatctgata ttcatcgatc agcctctttt 1001221 ttgtatgttg caagagaagt gaatcttcaa tttttcggtt cggcaaacgg tcataaacga 1001281 cgttcggcaa tggaacgatt tttttctccc agccgttttc cctgtaaagg aggccttcaa 1001341 tcgtgccttc ctcccaattg atttggtgcg cgccaaaaac gaagcagtag cccccggctt 1001401 gctcgtgtaa cgtgacaagt ttagaaaaaa agagggaacg atccttaaat gggcgttcaa 1001461 gagatacagt aaaccctgcc gtaaagatgc cgactaacgg cccgatatgc actgtatgat 1001521 catgaatcag tatatctgcc ctgcttcggt ggggaagcaa aagctcatga aacagatttt 1001581 cagagagaag cacggtttgt tccagatgcc gtctgtaagc aacgtggcat ctgacaacct 1001641 tcgttccgaa tgcggcatgc aaaagtccgt cttgcttcag cgaagagggc agaaacaggg 1001701 tgttttcact ggttttgtct atgccgatca aaaaccgttt aggattcacg cggaagaact 1001761 cctttctggc tttgctcaga aaacagatat tggcagcgtt ttaggggaca agtgtacagc 1001821 tgttcttttt gctcgggaga gacacgcagg attgacttcc tgcctggttt ggaattgata 1001881 tctaaaatcc aaattctccc gtcctttgca agacatatat caagaccgag ttcaaacaac 1001941 ggcccatagc gctcgtcaag ataatacgga accgattggg taattgaaaa cacatcatct 1002001 agtaaaacca cttgctgttt tttcggtata tcttcaaacc aggagtcaaa tgtcagcgca 1002061 tcagatccgc ctgacaaatt ggccagcagc ccgtgtttgt atccgcgtct tactgccttt 1002121 ccgactgtat tccattcacc tgcttcgttt ttttccataa acagacgaat atcacaaggg 1002181 tattgttcct tatcttgaat gtttaagtaa ggctgaagca aatattgatg ctgaagcact 1002241 tttttgcacc atgttttaaa agaagtctgg ttggaaaacg tttttgtctg cttatccttt 1002301 ccgatgtgat aagtagcagt gatgtttttc ttgcccagct tcaaaagaat cacgcctctg 1002361 cctcccgcgc cgaatgccgg tttaaggatg caggcttttt ctttggataa aaaggagtga 1002421 atttgttcgt agcggctcac ctttatcgtt tcgggaatat agggattgat tacagagtgc 1002481 tgctgcaaat cgtgaaggac ggtccactta tcgggaagac cccgcccgat aaattccgtt 1002541 ttcggatatt ttttgagcca ctcaacgatt ggttttgctt tttgggaatg tgaatccttg 1002601 ccgtaaaaac agcgatcata aatataatct ggaatcgcca tttcagtttc gttccatgtg 1002661 ctgctggccg aatgatagac cgatgctttg acacgcaaag tgtcaggtga aatatcaaat 1002721 ggtgtaaacc ggatgaaacg tatgccgaat tcgggtgctc ttttggccag ttctgcggaa 1002781 taatccgctt catgctggcg ggataaggac ataaaaccga gtgttatcat ggtgagactc 1002841 ccccttttat tcaaaagctg ccggcgggtg tccgcagctt tacactaaat acatgtaaga 1002901 cgaacgcagc tgacggtatt ctactttaca gaatacgatt ctccaccttg ccctattcca 1002961 aaagaacaag ctgattttct aagaacagga atttgtctcc tcgtttgcta agtgattgca 1003021 tgagcctcta taatacgtat aggtacataa tctatatgaa aaaagctgaa gcacagatgg 1003081 aggaagatga ataggaatgg gtattgcagg aacctttatt tttatgatcg tgatcggcgc 1003141 tgccattgga gcggtgacca atcatttagc aattcaaatg ctgtttaggc cgtataaagc 1003201 gtactatttg tttgggaaac gagttccttt tacgcccggg ctgattccaa gacggcgaga 1003261 tgaacttgca aaacaaatgg gactgatggt agtcaatcat ctcttaaccc ctgaaggcat 1003321 taaaaagcgg ctcgtctctg atgcagccaa aacgcaggct cttcgagtgg gggaacagct 1003381 gattcaaaag ctgtcacttt ctgaagtgac agtaaaagaa gcgcttgaaa aagccgggat 1003441 gaagcgcccc gaaaaagctg ctgatgcatg gatcagcagc tggaccgatg ataagctgca 1003501 tgagcttttc cgccaatacg gggaccaatc gttaaaagag ctggtgccta tagaggtgca 1003561 ggaaaagctt gaggaaaaaa ttccgatgat ttcaggatat atattgtcac ggagtgtccg 1003621 ttattttgaa agtgatgaag gaaaaatccg tcttggcaat atgattgatg actttttaaa 1003681 agagcgcggc atgcttggaa gcatggtgca attgtttctt ggcaattcaa gccttgcgga 1003741 tcgcgtgctg ccggagctgc tgaaattctt gcgcaatgag gaaacaaata aattgctttc 1003801 tgatctctta aaaaacgaat ggggcaagct gagggagtat acgtttaatg aagcagatga 1003861 aaaatggaat gcaaaggcgc tcattttcag tttgaaacga agagtgctgc aagcattttc 1003921 gactgcccct ttcttcaaca atacgattgg cacgcttacc gtccgctatg aatctgagct 1003981 gacccagcaa atgctgccgg cactattaga caaattgctt gaaggtattt cgtccaacct 1004041 tgaaagtgtc ttaaaacggt tgcgtcttga ggaaatcgtc aaggagcagg tggatcagtt 1004101 cccggtggag cgtcttgaag aaatggtgct gtccatttca aaaaaagaat ttaaaatgat 1004161 tacctatttg gggggccttc tcggcggaat tataggcgcg attcaagcat tgtttgtcat 1004221 ccttttttaa gaagaaatgg tttttgatta atgaaaggag ctccatagtc tgttatagtg 1004281 gagtggtatg tcaaacggca atgatgaaag gagctattta caatggctgt taatttttat 1004341 gatgtagcgt atgatctgga aaatgcatta cgcgggagcg aagaattcac ccgtttaaaa 1004401 aacctttacg acgaagttaa cgcagatgaa tcagcgaagc gcatgttcga aaacttccgt 1004461 gatgtacagc ttagactcca gcaaaaacaa atggcaggag aagagattac acaagaagaa 1004521 gtgacgcagg ctcaaaaaac agttgcgctt gtacagcagc acgaaaaaat ttctcagctg 1004581 atggaagcgg agcagcgcat gagcatgctg attggtgaat tgaacaaaat cattatgaag 1004641 cctttagaag agctttacgg cagtgttgaa ggctaataag caaaatccct tcttggataa 1004701 gaagggattt tttattcact cagcaaactt ggaaatccaa tgaatctttt acctctccat 1004761 tgatgatgac tgataatgta tgaattcctt tgtaatgctt tctggtggtt aaatccttaa 1004821 aggattggat tcttgtgtat gacttcgttt cgttttttcg tatatttgtt tctgttattt 1004881 taaatacttt ctgatgacgc tggcctcttg cttttacaaa atcaattgcg tactcaattc 1004941 ttactttttg atccctgtct gaatgaatat agaaagaaaa ttcaaggctt tcgccaataa 1005001 ctatacgttt gggctggcat gttaaatcat gtagttgtat cgaatcagca ttttcataac 1005061 caaaaagcgc taaggcctgt ttatcaccct tttttaataa ggtccgatag gcgtgtttga 1005121 taatccagtc tgtatgggga tgtgttccgt accattgatc tgcgactttt ctcagtaaat 1005181 gaggatgcgt ttttgatata tcattaaggt tgttggccac gctttttctt acatataaag 1005241 actcgtcctg catcagcttc tcaaggatcg gcaatacggg ggaagggtcc gatttcaaag 1005301 ccggtatcga ttttccccat ggcaggcggg gcctgctgcc ttcgctcgca agtcttctca 1005361 cgtgttcatt tttatgctca gaccatgcaa gcaattgtgc aatcatcttt tcttgatcta 1005421 acagcaaaaa aggccttaca gcaaattctg aggtcgaata ttgcgtaaag gattccaatg 1005481 cctttattga ttcttcccaa tgcgctaacc cgtactgttc cacataatct ggaaataaaa 1005541 ttccgctgag tcctttaaaa tgaggggctg tatcccgtaa aattgtgagc gcttcaacgt 1005601 attgttttgg caaagtttcg tataaagaaa ctgtcacgcg gcgcatccgc tcttttaaag 1005661 tgagttcagg ccagtcctcc agccgtaatg tatccaagaa tctgtttttg ttaaaatcag 1005721 gataggatga ccttacatga tggatcaact gagatatcag ttcttcatta tatatttctt 1005781 ttaaatcagc catataaaca ccgctttttc gtttattatt tatattgtat gggaatgtac 1005841 gttctggatc aagtgtatag tcctaaaaat taacaactga tcctaccacg gatatacaaa 1005901 agttggttac tttttttagt taaaaaaacc cttgtcatcg gaaaggaaaa ctgagataat 1005961 aacattgaaa gcgcctacac ttacctattt caaatggata cggtcgcata tcatgccgtt 1006021 atatagaggg gataagcaac agagagtaag tgttcggagc gcatcattgg tcaaacaagg 1006081 ggttcctgat acatgatttt tcgtaaatcg aaataacgat attagggaga atggctgctt 1006141 cgatcgtatc ctatcaacaa gccatacata aagtctgctg agccaggctt tttttgcttt 1006201 aagaaaaggt tgttctaaac acagagacag ggtcatatcc tatacacaag tacagtcatc 1006261 aaggaggggg acatctctgt gtcaaaacaa ttgcttgcct taaatataga tggagcgctg 1006321 cttcggtcga acgggaagat tcatcaggca acgaaagacg cgattgaata tgtaaagaaa 1006381 aaagggattt acgtcacact tgtgaccaac cgtcattttc gctcagcaca gaaaatagcg 1006441 aaatcgctaa agcttgatgc caagctgatc acccatagcg gggcatatat cgctgagaaa 1006501 attgacgccc cgttttttga aaaaagaatt tctgatgatc atacctttaa cattgttcaa 1006561 gtgctggaga gctatcaatg caatattcgg cttcttcacg aaaagtattc catcggaaac 1006621 aagaaaaagg tgaattcgaa tttattaggg aaagcactca ttcatccgtc tgacccgatc 1006681 ttttatccag tccagttcgt tgaatcatta agcgatctcc tcatggatga gccggtgagt 1006741 gcacccgtca tcgaggtgta cacggagcac gacattcagc atgacattac agaaacgatt 1006801 acaaaagcct tccctgcggt ggacgtgatt cgcgtaaacg atgagaaact gaatatcgtc 1006861 ccgaagggtg tctcgaagga agcgggtttg gccctcgtcg cttcagagct gggcctgagt 1006921 atggatgatg tcgtggccat tgggcatcag tatgacgatc tgccgatgat cgaacttgcc 1006981 ggtcttgggg tagcgatggg gaatgccgtt ccggaaatta agagaaaggc agattgggtt 1007041 acaaggtcca atgacgagca aggtgtcgct tatatgatga aggaatattt ccgaatgcag 1007101 cagcgaaaag gatttcttga taagttccac atgaaacgtg tgtaaaaaag ccgctcgcgc 1007161 cctgacaggt gcggcggctt ttttgccgga ttgattttag cagtttattt ctgtacacta 1007221 aagaaagttt tgaatctgat aaattaggtg atgaagttgc aaattaaaat agaaggcata 1007281 catgatgacc gcctgcatcg gcctctgcaa aatattgcaa atttgtttta tgaagagtgc 1007341 gagcttgcgt atggcggaga ggagcccgca gattttgtca tttctttagc gttgtcacaa 1007401 acggatgagc atgtgacggt ttctggagaa gtgaagggta ctggcataaa ggaacagcat 1007461 acaaaattct tttctccaga catgactgaa aaagaagctt ttaagcaagt gaaaaacaca 1007521 atttcttatg tgtatctcaa tcttcttcag gcgcatacgg gcattacgca gaagtgggga 1007581 atcctcacag gaatccggcc cacaaagctg cttcataaaa aactgcaaag cggaatgtcc 1007641 aaggagcaag cgcatgctga gttgaaaaaa gactatttaa ttcatgatga aaaaatcatg 1007701 ctaatgcagg aaattgttga ccgtcagctg gcggcagtgc cggatttgta ccgagtaaag 1007761 gatgaagtca gcatttatat cggcattccg ttctgcccga caaaatgcgc gtattgcaca 1007821 ttccctgcgt acgctatcca aggacaggcg ggcagagtcg gctcattcct atggggactg 1007881 cattacgaaa tgcagaaaat cggtgaatgg ctgaaggagc atgatgttaa ggttacaacc 1007941 atttactttg gcggcgggac gccgacaagc attacagcgg aggagatgga tctgctgtat 1008001 gaagaaatgg tccgctcctt cccggatgtg aaaaacattc gtgagattac ggtggaggcc 1008061 ggtcgtcctg acacgattac agaagaaaaa ctcgccgttt taaacaaata tgacattgat 1008121 cggatcagca tcaatccgca atcctacgaa aacgaaacgc taaaggcgat cgggcggcac 1008181 catacggttg aagagaccat tgagaaatat catctgtcac gccagcacgg catgaataat 1008241 attaacatgg acttgattat tggtttgcct ggggaaggcg tgaaggagtt caggcacagt 1008301 ctttcagaaa cagaaaaact gatgccggaa tcccttaccg ttcatactct ttcatttaaa 1008361 cgggcgtcag aaatgacgag aaacaagcat aagtacaaag ttgccggcag ggaagaggtt 1008421 tctcaaatga tggaagacgc ggtagcctgg acgaaagagc atgggtacgt gccttattat 1008481 ttataccgcc agaaaaacat tcttggaaac cttgaaaacg tcggatactc tttgccggga 1008541 caagaaagca tctacaacat tatgattatg gaagaggtgc agacgattat tggcatcggc 1008601 tgcggcgctg ctagtaaatt tattgatcgg gatacaggga aaattacgca ttttgcgaat 1008661 ccgaaagatc cgaaatcgta caatgagcgc ttcgagcact acacggacga aaaaatcaaa 1008721 tatttagagc agatttttga aaaaacgaca aagcagcact gattacagtg ctgctttttt 1008781 tatccctgtt tttttgcggg ctgaacctca ggcttccatt taaatacctt gttcagcaag 1008841 cggtaaattc gttttgattc ctttgtgaca agcggtccca aaatcgccag aatgaggaca 1008901 tataatgcgg caaacggctt taatgtggcc gacagtccgc cggctatccc gagattcgca 1008961 acgataatcg aaaattctcc ccgcgatacg atcgtcagcc cgatattcga tgaagcctta 1009021 tgagaaagcc ctgcgcgtcg tcctgccacc attccggcga taaaatttcc cagaatggtc 1009081 aaaatcactg cacccaacgc aagccaaacc gcttcaccaa gcgaaaacgg atcgatgctg 1009141 aggccgaagc tgaaaaagaa catcgcaccg aagaagtcgc gaaacggaac aacgaggtgt 1009201 tcaatcctat cggaatgctc tgtttctgaa aagaccaaac cgagcagcag cgcgccgatt 1009261 gcttctgcta catgaatcgt ctctgaaaaa ccggcgataa aaaagagtgc tgcgaaaatg 1009321 acgataataa acacttcgtt tgagcgaatg tccaacagtt tgttcaacag cggcgggagt 1009381 tttcttgctg cgataaaaaa cagcagcata taaccgaagg cgatcaaaat ggacaagagt 1009441 gcactcccta cggatgtcgc atcacctagt ataaggccgg aaacaacgga cagatatacg 1009501 gcaaggaaaa tatcttcaaa catgatgatg ccgagaatca attcggtttc cgggttggcg 1009561 gttcttttta aatcaacgag cacttttgcg acaatcgcac ttgacgagat tgtgatgacg 1009621 cctgcgagga tgaggacttc cagaaaggaa aatccggtga taaacccgta aagcagtccg 1009681 aggctgaagt taatcaaaat ataaatcgtc ccgccgaccg cgattgattt tcctgatttg 1009741 attaacttcc cgacagagaa ttcgagtccg agatagaaga ggaggaacag tacgcccatt 1009801 cgcccgaaaa actcgatgat ttcactgctt tgaataaatg ttagatcaat aatccccatt 1009861 ttcggcgcgt gcggtccaac aagcattccc agcacaatca gaaacggaat aatcgaaaat 1009921 ttaattttat tggcgatcac actggcgatt gccacaagca caagtgcagt tccgacttca 1009981 aatacaagat ggtccatcgg ggctcacacg ccctctccag aaagaaaatc gtgaatcagt 1010041 ttcttcagat gctttctctc acctgagagg acaagggtgt cattttcttc aataatcgaa 1010101 tccgctccgg gatttaggag cttttcctgg ttgtgtttga taatcgcaat aacagtgaca 1010161 tcgtaattct ggcgaacatc aagctcaccg agtgtgcgtc cgatcgattt ggcgcctttt 1010221 tcgaccttaa accattcaat aataagatcg ctgaaggcca tttcgatgga ctccagagct 1010281 tgcggtttat agaccatgcc cccgagaata gctgcaattt gccttgcttc agaatcatcc 1010341 aatgaaatat ttgaaagaag ctcatccggg tcccggtcat taaaccggta aatttccctt 1010401 cttccgtcat catgaatgat aatcgtcatt ttttcgtggc ttcttgtttc gatttcaaac 1010461 tttttgccga tgcccggcag atcgttttct ttaatattca atgaaaatcc ctccgaatgt 1010521 agtgttggca gtatggggtg agttacaaat aaaacttgag caaattatat tcggaggtaa 1010581 ttagactggt atttgacagg gacggccaaa gccttttcca gcctgtttat cagcggttcg 1010641 tcaagtggtt tgacagagag ctgcctgaca gactgcgcca gcgggctgta ctctttgatc 1010701 agctcagccg ggtgcatgct gcccggcgat ggcgtttttg ccgattgtgt ttcctgcgga 1010761 tatgaagaca taggcacata gctgtcagtg cttgcttcaa actgggaagg cagaaccacg 1010821 tccgaagggg gaaagtacac cataaataaa cttaacagaa aactgatcag caatttatcc 1010881 atgttccttt cctcccttct catcaagata tcccttcttt ttcactatat aaaactttat 1010941 gtttccattc aaacaatatg catttttcag tatctattga ccttgaaaaa taaaaaggtt 1011001 tatttgggga tggcggggaa tgtataggag aaagaaaaaa gtaagcgcat acatggaggt 1011061 gcttttaatg gagtttgttc aatatgcatg taatggggcc gttgcagaga ttatcctgaa 1011121 tcggcctgat gcccatcacg ccctgaatga acagatgctg tctgaattga aggaggcagt 1011181 cgaaatggcg gctgcaagcg aggcgctcat cgttctcctg agaggaagcg ggaaaggctt 1011241 ttcggccggc ggtgatatca ggatgatgac gtcagagcat gaccctgacc aatttaaacg 1011301 gctgatggat acgattgagg ctgtcaccct gaatttatat cagatgaaga aagtgacaat 1011361 tgcagccatt catggtgctg ctgcgggact gggcctgagt ttggcgcttt gtgcggacat 1011421 tgtgctcgct gaaaaaaacg ccgttctcgc gatgaatttt atcggcattg ggcttgttcc 1011481 ggacggcgga ggacattatt tgctgaagaa aagaatcggt gaagcaaaag cgaaaaaact 1011541 gatttggagc ggaaaaaaac tatctgcctc ggaagctgcc gatatggggc ttcttgatgg 1011601 gacatttgcc ggagaccctg ccgaaggcgc aagacccatt atcgaaaccc tgttggcctc 1011661 ccctcttttg gcgatgatcg aaacgaaagg tatttttcaa agcctccaaa ttgaagaact 1011721 gaaaaaagtg ctatcccttg agcgcagcgc ccaagagaga atgagaagga ccaaggatca 1011781 ccaagaagga atccgtgcct ttttagaaaa acgggagccg aagtttcaag cgtaacagat 1011841 cagccggaaa gctgatcatc tgtgaaacaa aatcagcttt ccggctgcat tgactaaacg 1011901 atgagtatga ctatgaagct ctttttcttt taagagggct tcaccatgcg tttttgccgc 1011961 ttcttcatgt tctgcctcga attgctcgtt taccagcgtg ttccccgaag gatcaaatac 1012021 ggtaaggaaa taatcagcca tcaggtttct cctccatttt aaggtttatc agtctttctt 1012081 catttatatt ctaaaaagga aatcaaaatc ctttattatg ctttatccaa aattagtata 1012141 taatgggtca gggaaggagg agattcagtg cttacaattg atcacgtaac gaagacattt 1012201 ggagattata aagccgttga cggattggac ttagatattc cggaacagca aatgttcggt 1012261 ctattaggcg caaacggagc gggaaaaaca acaacgtttc gcatgatcct aggattatta 1012321 agcattacgg agggctcaat cagctggaag ggccgtcctg tgaattatca tatcagcaac 1012381 aaaatcggtt atttgccgga agagcggggc ctttatccga aaatgaaggt aagggatcag 1012441 ctcgtctatc ttgccagatt aaaagggatg gagaagcgag aggctgtaaa agagctcggg 1012501 acatggcttg aacgcttcaa tattacagat tacgagaata agaaggtgga agagctttcg 1012561 aaggggaatc agcagaaaat ccaattcatt tcggcagttt tgcataagcc ggagctcctg 1012621 attcttgatg aaccattcag cggcttggac cctgtcaatg ttgagctgct aaaagaggcc 1012681 gtgatctcgc tgaaaaacag cggtgtttct attttatttt caagccatcg gatggaacat 1012741 gtggaggagc tttgtgagaa cctttgcata ttgcagaaag gaaaaccggt tgtacaaggc 1012801 aagctgaagg agatcaagcg ttctttcggt aaaaagaatg ttaccattca ctccgatgac 1012861 gatctgcgct ttttgcagtc ccatgaaggc attcttcaat ggaaggaaac ggcagacggc 1012921 gtcaagctgc agattgccaa tgaagacatt tctcaagaga tttttgcgat gctccaagga 1012981 aaagggttta tcagaaagtt tgagcttgaa gagccgtcac tgcatgatat ttttatagaa 1013041 aaggtggggg ccgtctatga ataaattttg gatcatgctt tctcatacat acaaaaataa 1013101 gattatggca aaatccttta ttatttcgac tgtcatcacg gtgctgcttg ttttagttgt 1013161 aacgaatctg gagtcgatca tttctttgtt tcaaggtgac gatgcgaaag aaaaaatcgc 1013221 cgttgttgat gaaacaaacg aattatatcc ggttttttct aagcagctga aagcggtgga 1013281 tacagacggc gatcttgatg tgaagctgtc gaagcaatcg gaggatgagg tcacaaagca 1013341 agtcaaagat gaatcactcg atggcatgct catcatcaaa cgagatgaaa aagggaccat 1013401 ttcaggaaca tataaagcgt taacgatttc tgatgaaagc acgtatcaaa cactgcagca 1013461 ggcgctgacg caaaccaaaa cagctgtcgg aacagcggag ctcggcgtgt cgcaggaaac 1013521 gattagcagc ctttatgcgc ctgttactgt ggggcagaag gcgctgaaag aaggggcaaa 1013581 gtctgaggaa gagcttggcc agacggtagg gcttgtttac attatgctgt tcgtcattta 1013641 tttctcggtg attatgtatg ccagcatgat agcgatggag gtcgcaaccg aaaaatcttc 1013701 gcgagttatg gaaatcctga tctcaagtat gccgccgatc cagcaaatgt ttgcaaagct 1013761 gcttggtatc gggcttgtcg ggatcacaca gcttgctatt attataggag ccggctctct 1013821 gtcgcttaag ctgaaccaaa agagcgaaac ggcttcatct gtcggcggat tccttaattt 1013881 gaccgacgta tctgcaacca ctgtcatcta tgctgtcatt ttctttttgc tcggatactt 1013941 tttgtacgcg acacttgccg cgtttctcgg cagtgtcgtc agcagaatag aggacgtgca 1014001 gcaaacgatc acgccgatga cgcttttggt tgtcgccggt tttatgatcg cgatgttcgg 1014061 tttgaatgcg cctgacgcag gatttattac ggtaacttcg tttattccgt tctttacgcc 1014121 aatgattatg ttcctgcgcg tcggcatgct tgatattccg ttctggcagg cggctgtcgg 1014181 aatcggaatc acactgctca ccattgtcat actggccgtt atcggcgcca gaatttataa 1014241 aggcggtgta ttaatttacg gcaattcaag cgcgttcaaa gcgatcaaac aagcgctacg 1014301 tttagcgaaa aactgattgg aaaacagcct ggggattctc aggctgtttc tttattgaca 1014361 gaacgtgcat tcgcaagaat tcggtgctaa aataagggta cttcatcctg gaaaggagca 1014421 gaatgttgac tgatctaacc tttattcatg cggcagatct tcatcttgac agcccgtttt 1014481 acgggatatc gcatctgccg gagccgattt ttgcccggat taaagaaagc acgtttgcaa 1014541 gcgtgagaca tatgatagac gccgcagtga gagagcacgt tgatttcatt ttgcttgcgg 1014601 gagatctgtt tgatgaagcc aatcgaagct taaaggctca gctctttttg aaaaaacagt 1014661 ttgaaagact cagagagtgc ggaatttcgg tatacgtcat ctttgggaat cacgatcatc 1014721 ttggcgggga gtggacgccg attgaatggc ctgagaatgt ccatattttt tcgtccgctg 1014781 ttccagaaga aaaatcgttt tttaaagaag gcaggcgcat agcaagcatt tacggcttca 1014841 gctatcaagc cagagcattg atggaaaacc aagccgcccg ctatcggaga tcaactgacg 1014901 caccgtttca tatcggcatg ctccacggca cgctgtcagg atctgaagga cacgatccgt 1014961 attgcccgtt tacacatgac gacctcgtga aaagcgggat ggattattgg gcgcttggcc 1015021 atatacataa acgccaggtt ctatctgccg agcatccggc agtcatttac ccgggaaaca 1015081 cgcaagcacg ccatataaag gagacgggag ataaaggcta ttatctcgtt catgtgacaa 1015141 acggagatat atcttatgaa tttcagagag cgcatgatgt cctgtgggaa aaagcggcgg 1015201 ttgatgtgac ggaggcaaag aatatgacag ccctcttcca aatggtggag gacacgtttt 1015261 cgaagctgcg gaaaaagggg agccctgttt gtgtaaggct tgttttacaa gggacggcgc 1015321 cggaatggct gctggaggcg ccaaaaggca ccttggatga gtttcttgaa gctcttcagg 1015381 aacaagaagc ggaagaggaa cgtttcgttt ggcctcttag attggacgat gagacagaaa 1015441 acgaagcaaa cctaacaaac cttgatcctt tttttggcgg tttatttgaa gacattgatc 1015501 gcagcgatct gtcagacgtg ctggaagggc ttgagcggca tccagtgtat agaaggcacg 1015561 cggaccggtt tagccaagag gaggtaaagg aaataaaaga gcaggcacag ataatattga 1015621 aaagacagct taaggtgctt gatacatgag gcggtgacag ctttgcgaat tatatcttta 1015681 catatctacc aatacggaaa attttccaat cggacctttg acttttccgc ctctcctgtc 1015741 caagtcatct acggattaaa tgaggcagga aaaacgacga tgatgtcatt cattgaaagc 1015801 atgctgttcg gttttccgaa aacgaaaaag tatgaaccga aaacaggcgg tgtctacggc 1015861 ggtgttcttg aagctgaaca tcctgagtat ggggtgctga agatcgaacg gacgaaaggg 1015921 actgccgaaa aactaagcgt gtacacagaa aagggcgaag taaagcaggg agatgtttta 1015981 aagcagctgt tccagggcac agacaggtcg ttgtacaaag ccatatattc gttcgacgta 1016041 ttcgggctgc aggaaattca cgcctttaat cgggacaaga taggggaatt tttgctcttt 1016101 tccagcttgt ttggtgctga agccgtatca aagcttgatt caaggctgac gaaggaaagc 1016161 gaaaggctct ataaaccaaa tgggcgaaac cctcaattga atcaggagct ggaaacgctt 1016221 aagcagctgg cagttaagct aaaacaggct gaagcagagg aagcgggcta tcatcagctt 1016281 ctcgaggaaa aacgaacgct tgaagcccgc cttgcagccg cggaaaccga attgaaagag 1016341 acggcgggac atatccgaat gattgaggga gcgattgagc gaaagccgct gctaaatgaa 1016401 aaagcgacac tcgaacaggt gattgcagaa tttccggaac acgcaggaca atttcctgct 1016461 gacggactgc atcagctgga aaaatatgaa tcccatcttc acccgaaatc agcacagctt 1016521 gaggcgcttc gggtgaagat ggcggagttg gacaaacaga ggcaaaagct tatccccgat 1016581 aaagaactat tggcgaaaga aacgctgata caagagcttt cggcagcgtt tcatatgtac 1016641 caatcctggg gagaacagct ggcagccatt caggcacagc tgcgccagac gtctgcgcag 1016701 acagcggcag ggctggaaca gctcaataaa acggatgaaa atgagctcct gaatatgaac 1016761 acctcatatg attatgaatg gcagcttcag caagcggtgc agcaatatgt acaggcaaga 1016821 gacagaaaac ggcagcttga cgagacgttt gaacttgccc ggcaagagct ggaagacgcg 1016881 gaaaaggccg ttcgtgccgc ttcgtccgcg attcttgaaa acagccaaag aaaagataaa 1016941 gaagcagctc ttagagcata tgatgaaaca caggggcagc accaagagca agcgaagctc 1017001 agagaacagc taacgttttt tgaaagacag caggctaaac agaaaaagac tgtcattgca 1017061 gctggtatgt tgttcatcgt tctcttttct ctgctgcagc aatggattcc cgccataagt 1017121 ttcggcgctg cacttattgt gtattggctt gtttcaggaa agtcgtcttc tcgaaacagc 1017181 cgagagacaa gacagcccat gacggatatt tcaccagcag aagctgaaat gcttagagaa 1017241 gcgttatggg aggatgaccg caataagcag caccttctca cacagcgtgc agcgctccag 1017301 caaaaagagg cggcgtatga aagggtcatc cagcagtttg aacagtggga agccgaaatg 1017361 gcgccgtcct ttacacaggt tgagcgtttt atgaatgagc tcggatttaa ggaagatcca 1017421 tcatttttgc ttgatgcata cagcttaatg aaggatgtta aaaaagaagt gaagaaaaag 1017481 catgagctga ccatagaagc aggcaggctg aaaaagcacc ggagaacatt cgaagaacgc 1017541 gtcagtatgc ttcttcccgt gaatcagagt caggatatct ccatttcgga cgcccttcac 1017601 acattgcgga aaaacattga acgtgaaaaa gaaattgaga agcaaaaaaa ggaaattgaa 1017661 acagatattc attatacaaa ggaacagatg cttgaacttg agcaagaaat acagtatttc 1017721 cacgcacaga ttgaacagtt atttgccgcg gctgctgcaa aagacagaga tgcgtttttt 1017781 gccatagccg ccatcagcag gcaattgaag gatacggaga acaagcttca tcacgtaaac 1017841 gcacagcttc aaggcgggta cccggaggaa cttgaactgg cggattccaa tacgctttct 1017901 gaattgaaag ataagcaatt tgttgagaat gaaagaaaag agcggctgac tgaggagatc 1017961 gagcagctcc gcagccaaat cgcactgctc tcagtcaaac aggaacaatt agaggcttcg 1018021 ggaatggtct cagacctcaa gcttcaaacc gaaatgcaaa aagaacgtgt gaaagaaacg 1018081 gctaaaaaat gggcctccat acaaatggtc aaacaggtga tcagaaacaa attggagcgg 1018141 cataaaaaaa tcgagcttcc gcgccttctg gagacggcag gagaattttt ccgtcctctg 1018201 actgacggaa actaccaaac catttatttt tccgaaacgg atgattcgat catggttatg 1018261 catcgcgatg gcactgtcta tcatgcggaa gagctgtcac aagggacgtg tgaacagctg 1018321 tatacagcga tccgctttgc tttggccgtt acgcgccagg gtgagtcaaa gcttccgttc 1018381 cagcttgacg acagttttgt tcattttgat caggaaaggc tgaaacgtgt attacatgtt 1018441 ctgtatgatt tatctgaagg cggtaggcag attttgtatt ttacatgcca tgagcacgta 1018501 aaagatgcat ttcatagcag ccaaatcatc catttggtgt cataaaagag gttctatagc 1018561 tgaaaatcgg tatgtgatat actggtatta tgtaagatac ggagggagct ttaatagaat 1018621 ggctaaaggg attatgctac atgaggttgg cgaacaggtg gaccagtatc tattgattaa 1018681 atcctcgacg aaagggattg caagcaatgg aaaaccgttt ctgacgctga tgctgcaaga 1018741 ccagtcaggc gatattgaag cgaagctgtg ggatgccaag caaagtgatg aagtgaccta 1018801 tgcgccgcag acgattgtca aggtcgtcgg cgatgttcac cattatcgcg gacgcaccca 1018861 gctgaagcta agaaatatca gaccggtaag cgagcaagaa aacgtcaata ttgatgattt 1018921 tttagaaacc gcgccgattc cgaaaaatga aatgatggat accatcactc aatatatatt 1018981 tgaaatgaaa aatccgaata tccagcgaat cacaaggttt ttggttaaaa aacacgaagc 1019041 tgagtttatg gattatccgg cggctacgaa aaaccaccat gagtttgtct caggtttggc 1019101 gtatcatgtt gtctctatgc tgaacctggc gaaagcaata gcagatttat atccttctct 1019161 tgatcgtgat ctgctttacg ccggtgttat cctgcatgat cttggaaaag tgaaggagct 1019221 gtccggccct gtttccactt catatacggt tgaaggcaat ttgctcggcc atatttccat 1019281 catggtgaca gagctttcaa aagcggctga ggagcttcaa atcgattctg aagaggtgtt 1019341 aattcttcag catttgattt tgagtcacca cggcaaagca gaatggggca gcccgaaacc 1019401 gcctatggtg aaagaagcgg aaattcttca ctatatagac aatctggatg caaaaatgaa 1019461 tatgatggac agagcgcttg agcgcgtgaa gccgggcgag tatactgaac gtgtatttgc 1019521 actggaaaac cgttcctttt ataaaccgac atttcataaa taacttaaaa aggactgatg 1019581 ctgacatatt cagctcagtc ctttttgatg cgtctttccc gcacataact cgtctcattc 1019641 ccgcatatgg ttaagaataa agaatctatg caaaggggga ggagcccgtg ttattttttc 1019701 cgtggtgggt gtatctttgt attgtaggca tcattttcag cgcatataaa cttgtggcgg 1019761 cagccaaaga ggaagaaaaa gtagaccagg cttttattga aaaagaagga cagatttata 1019821 tggagaggat ggaaaaggag cgagaacgcc gcagttctca gcagcatgaa gaagaaaatc 1019881 aaaaccattc catcgcataa aaaaagctgt gcggctcaat gagccgcaca gcttttttta 1019941 ttatttagaa ttgcttgaag atgaagaagt gctgttgctt gttgaagatg tattaaatgt 1020001 gtctttcaga tctttatctt ttacttcgat gtcagccttc ttcatgactt tttgaacagc 1020061 ttcctgaaca gctgcgttgt catttaattt ttgttcaagc acttcagatt tcagttcttt 1020121 tttcatatca tcatatttgc cgcgttcttc tgtcttttta atgatatggt agccgtattg 1020181 cgttttgaca ggatcactga cttcacctgt ttttaatttg aatgcagctt tgctgaatgt 1020241 ttcgtccatt tggccttctt ttgcgaacca gccaagatcc ccgccttttg aagcagagct 1020301 gtctgttgag tattctttcg caaggtcttc aaacttctcg ccttttttca gctttttctc 1020361 tacttcttca gctgtctttt tatcagcaac aaggatgtgg cttgcacgga ttttgccttt 1020421 taagccttcc cagtactctt tgatatcggc gtctgttact ttgatgttat ctttagccgc 1020481 tttttgtgtc agcaattcat attttacttg ttctttcagg taatctttgc catattgctt 1020541 ttcgagggca gtatattgat cgccaagctg cgttttgtat tctttcagct tgttgtcaat 1020601 ttctttatcc gaaactttat acttcttgtc caatactttt tcttgcacta gctgtgtcag 1020661 tacgcttgcg ccagctgttt tcttcatgtt tgtgtaaagc tcgccttttg tgacatcgcc 1020721 tgcgtctgtt tttgcgataa cttctttgtc gccgctgctg caagcactga gagcgaggat 1020781 gcttgtagca gtgatagctg ctattgcgat tttcttcatt gttttcaaac actcctaatc 1020841 attccaaatt aaattaccta tgcgtatcat aacatattgt ggctttctgt aaaaagattt 1020901 taaataaagg gcattcgtct agtcaaactt ttgctgatga catacttata tattgatcaa 1020961 gaaaaggagg tatgtaacat gagcggagga tactctaacg gattcgcgtt gctcgtagta 1021021 ctgttcattt tgcttatcat cgtaggtgca gcttacatct actaagcagc ccgaggatcg 1021081 cttgcaacat aagcgatcct ttattttcac tagcgcctaa tcgtttcaaa catgaattgc 1021141 ataacatgta attggtaaat aaagcttatt acaggaggtg ctatttaaga tgggtgaagt 1021201 atttgcaggc ggattcgctt tattggttgt gttatttatt ttattgatta tcatcggcgc 1021261 ttcttggctg tactaatcaa cataaaaaag catagctgct taatcagcag ctatgctttc 1021321 tttcgtattt acactgtaaa ggagatctcc acaaacgaag agatcagtaa aattaatata 1021381 gatacattaa taaatcggaa taccttatct tgccgctctt caggaatctc tctgacaagg 1021441 cataatgtat tggtgagcct gtttatgaaa tataaaataa acacggcagc cacgataaaa 1021501 tagaataaaa tgatgggaga ttccccctct ctctgaactg tcccatatta cattaccaaa 1021561 tatttattaa aaaagataga atgcaaattg aaaaatcgcc accagcacca gggtttgact 1021621 acttttcaac aagaatatcc aagccgtcag cttcctgatc aataaaagcg gttttcggtg 1021681 cttttatcag cttgagagcc agcaggaaat caggcagaca gtagccggcg tgaatgcccg 1021741 agatcatgca aaaataatga gcgtgattcg gaaatgccag tgctgcgtaa aacaataccg 1021801 gtgtaatcag caagaacggg ctgacgagtg aaatcagcat tgttgttttt ggtatacgtt 1021861 tccatgtgcg catgcgcaat atgtaaaact ttttttctat ttttcttttt ttgcagatga 1021921 ttggcaggac atggatgact ttatgtacaa ataaaataac gacgagcaaa ccgccgaata 1021981 aagatacata ttcatcgctt aagcttgtgc caggccgcag cagctcaaaa gctaaaaagg 1022041 tagatataaa aaccaaaatc ataaaacata cagcagttaa tattatgcga acggcgccat 1022101 aatccttcat gagatttatg gtcttccagc aattcatcaa agtcatcctt ccatacatct 1022161 tgaatagaat ctcaaaataa tttactcctc ccaagagaaa aaatcaatgc ttttttaaga 1022221 aaaaatatca tccggcaggt atttttttga aacaagcaaa caaactgcga aatatggggt 1022281 tagaactttc ttctcagtga attatcagct aaaataagat taaagataga aagaagtggt 1022341 gtggatggat tcgatggatc atcgcattga gcgattagaa tattacatac aattattagt 1022401 gaaaacagta gatatggaca ggtacccctt ctatgcgctt ctcattgata aagggctgag 1022461 caaggaagaa ggggaagcgg ttatgaggat atgcgacgaa ttgtcggaag agctggcaac 1022521 acaaaaagcg caaggatttg taacctttga taagctcctt gcgctttttg ccggacagct 1022581 gaatgaaaaa ttagatgttc atgaaacaat ttttgccctg tatgagcagg ggctttatca 1022641 agagctgatg gaagtcttta tcgacatcat gaagcatttt gattaactgt ttacaggttc 1022701 gagctcttca gccggttcat ccgccgcact gtcctttgct tttttcttca attttccgtt 1022761 tacgctttca aagtcattgt caatattggt gagtgacgtt tcgaaaattt ccataaaatc 1022821 atcgccgtag atatggcgta tcatacacat catttctgcc acttcaggaa attttccgaa 1022881 taaatgatat aaaggctgtg accctttaaa aacagcgttg cgtgtcggat caaattcctc 1022941 aagcaagctc cagaatacct cggtaccttc ctcagtcaat tggacatatg tgttccgttt 1023001 atcattcagc cgtttggaga accttaaata tccccgttct tccagctttt ttgaaaagtt 1023061 gaatgcggtt gatacgtgca tgaccccgaa tttcgcgatt tcagaaatgg aagctccatt 1023121 caattgatac gcaatccata aaatatgatg ctcattaata ttcaggtcat acggtttgag 1023181 ccattgctgc caatccttct cgatcgattt ccaaagagcc ttgctaagct gagccatttt 1023241 ctgggtgaaa accagagctt ctttcacatc atagggcggt tccactcgat tcattacgtc 1023301 acctgcttct ctttttcttt ttctctatta tgccaataaa ataaagatta ataaagatga 1023361 aaatgtaaga attttttaat aaattcacaa accattgcga cgaaagggtt tttcggccaa 1023421 aaaaaatacg ggtccaattt tggcccgcat ttttttcttt tgaataggat attagttttg 1023481 taaggttttc tccagctgtc tgattttctc ttcgatatcg gcaatttctt tttgcagatc 1023541 ctgctggtga ggcttgatct cttcctgcca ttttttaatt gatgtttgga gctcgccgcc 1023601 cacgtcttta ataacatccg tgctttcttt tgccgctttg atcagctggt cttttaatgc 1023661 aagcccgtct gactttaagc gtttgattgt ttcttcaaaa gaatcataat tggttttcat 1023721 tttttcacgc agctgctttc ctgaggaagg tgcagtaaga agaaccgctg ctcctccgat 1023781 gatgccgcct acgaatagtc ctgttaatag agaacgtccg ctcgccatta caatcacccc 1023841 gtctttttct tcaaaatagg attcattcag catttttcat ttttgttgaa agcctgaact 1023901 tctatacata gcttgcttta ttttagcata ttttttaagt gaaaaggagg gagaaggttg 1023961 tctgtctttt tgattgtatt atcctgcatc acccttgcct tcgcttcagg cgctgtttac 1024021 tatatcaaac ttctcagcca ggctgcttct tatccgccca agagggttat ccggcagaaa 1024081 gcgcttgttt gttcaaccgg aaccgccttt acactatgtc ttatcttttt cacaaaactc 1024141 ctcgcttaaa acatgctgac atgctgcggg cgctctgttc aaaaaaacct ctcccggaag 1024201 cggaagaggt tttgtgtgac aattatttag cagcttccat aaagcttgaa cgccttaaaa 1024261 tggtttgcac aatcggataa ataatgatca ttgagattgt attcagcaca gcggccggca 1024321 gaacaacagc cgcgaacaat gcggcgaaac cgcccggtaa accgacgatc aataaagctg 1024381 acgatagaaa cacaattcct gataagatgg tcccgatcac tgtcagcaca gcggctgcac 1024441 ctgttttccg gctctttctg aacaagagaa acagggagaa gaacagaaac gctgatacgg 1024501 gtttatcaat gatgttaggg atctgtccgg ctggaaacgc ggttgtaagc gcggaaatga 1024561 ttccggtcac gatcccgatg acgagtacat tttgcacccg cgggaacagc agaatgccca 1024621 tgaacatcat gatcagcatc atatctggtt tcatgccgcc taaaaagggc ggaataatgg 1024681 aatgaagcgc tgcgccgatt gcggcaaaca gagccataat gactaactct tttgttttca 1024741 taactatgct ctcctctgct aagctttttg ccctccaata atatgctcat catttattgc 1024801 gaaggcttta cagaatgtgt tatgcaaaca gtataccaaa cggacggttt gcatagccag 1024861 actttttact cattttcctg ctggaatttc ttcatgaacg cagctaattt ttcacagtct 1024921 tcgagagaga ccgcgttata aatagaagcg cggcagcctc ccaccgaacg gtgtccgcca 1024981 aggccgatca tcttcgcatc ttttgctttc tgaacgaatg ttttcgttaa ttcgtcatcc 1025041 cgaagcgtga atgtgacatt catgcgtgag cggctgtctt ttctggcatg tcctttatag 1025101 aagccgttgc tttcatcaat acagctgtag agaacctgcg ctttttgttc attgcgctgt 1025161 tcaacagctt ccacaccgcc gttttccttg agccattcca gaacgaggct cagcatataa 1025221 atcgcaaatg tcggcggagt gttgtagagt gaatccgctt tgacatgcgt ggaatatttc 1025281 aagatttttg ggacgttcgc attttcattt tgcagccagc tttttttcat gatgactaca 1025341 gtcacgccgg aagggccgag gttcttttgg gcgcctccgt agatcacatc aaatttggac 1025401 acatcgattt ttctgcttaa aatatcgctg gacatgtcgg ctacgagcgg aattggagaa 1025461 ttcggaaact cctgccactg agtgccgaaa attgtattgt tggatgtgat atgtaaatat 1025521 gcgccgtctt ttacatccgt aaggtcaacc tctggaatat aactgtaatt gtctgtttca 1025581 cttgtagcgg tgatagacgt gttcccgaac agtttcgttt ctgccagtgc tttttcagac 1025641 caagcgccgg tcatcacaaa atgtgcggtt ttttcaggtg ttaaaaagtt catcggaagc 1025701 attgagaatt gaaggcttgc cccgccttga agaaacaaga tatcgtaatc ttccggaatg 1025761 cccatcagtt cgattaagag gcttttcgct ttttggtgca ccgcttcata ctctttgctg 1025821 cggtgggaaa gctccataac agacatgccg gattcgttaa aatcaataaa ttctttctgt 1025881 gctttttgca gaacttccag tggcagcgct gcaggacctg cgttaaaatt cgttgtacgt 1025941 tccattatga tctctccctg ttttccacgt taatgtataa aataatacaa ttatcctatc 1026001 acaaaaattc agttttttga taaaaaatta gaattatcaa aagaaattga cggatgtttg 1026061 cgaaatgttc acaaaataaa ataacctcat cttatgatga ggccaggcgt tttgcgatag 1026121 aggaagagat gttctgcaga tcctccggtt tataatcatc agcatgcgtt ttccaaaccg 1026181 ctccgaatcc atctcctttt ccgtagcgag ggataatatg catatggtag tggaacacag 1026241 attgtccagc tttttcgccg ttattgttca gcgtatttaa gccgatcggt tcaaattcat 1026301 cccggatagc gcgggcgatt tttggaacag catggaaata ttgttttgct aattcatctg 1026361 taaattcata tacattctca atatgtgttt tcggaatgac aagcgtatgg ccttttgtca 1026421 cttggctgat atcaagaaag gcaagtacat gttcatcttc atacaccttc gctgatggaa 1026481 tgtcgccggc aataatttta caaaagatac aattctctgc acaatgcatg agggttcctc 1026541 cttatgaaat tgtttagtat gtatacattc atcgtaccac agaaatgcag aaaatagaaa 1026601 acaggatgaa cggcgagcgt tcaccctgaa tgcagaggaa gagcttatat gaagaaaatg 1026661 tgttatgcct ttggtaagca cctcatttgt caataaaatg aagacttgtt taatgcctaa 1026721 cgattcctgc gataaacacc tcatttgaca atttgcttca tacatgaaga attcatcaat 1026781 tcagtgaaga gaaatggttt gagcattgga catgtttatt ttctatccaa ctgtttctaa 1026841 gacgtctttg acaaacacct catttttcag ttgatatgct tttcctctac aacttttatg 1026901 atgtccagaa ccctgtctct ttatgacagc aaattcatca tttgttaaaa gggaattgtt 1026961 tcaaatcagg ccttgttttt ggtactatga agaaaaacac tataagggga gaaactatgt 1027021 ctctgctatc ggtaaaagac ttgaccggcg gatatacaag gaatccggtt ttaaaaaacg 1027081 tatcattcac ccttgaaccg aatcaaattg tcggcttaat cgggctgaat ggtgctggta 1027141 aaagtacaac aatcagacac atcatcgggc tgatggaccc gcataaaggt tcaatcgaat 1027201 taaacggtaa aacgtttgct gaggatccgg aaggctaccg ttcacaattt acctatatac 1027261 ctgaaacacc tgttttatac gaagaattga cgctgatgga gcatcttgaa ctaacagcca 1027321 tggcatatgg actgtcaaaa gaaacgatgg agaaaaggct gcctccgcta ctaaaggaat 1027381 tccgaatgga aaagaggctg aagtggttcc cggcccattt ttctaaagga atgaagcaga 1027441 aggttatgat tatgtgcgca tttttggcag agcctgcgct ctacattatt gatgagcctt 1027501 ttctagggct tgatccgctt gccattaacg cgctgcttga acggatgaat gaagcgaaaa 1027561 aaggcggggc gagcgtgctg atgtcaacac acattttggc aacggcagaa cgctattgcg 1027621 attcgtttat tattttacat aacggcgagg tgcgggcgcg cggcacgctg tcagagctca 1027681 gagagcagtt tggaatgaag gacgcggcgc tggacgattt gtatcttgag cttacaaagg 1027741 aagacgctgg ccatgaataa tatgcttgat atttggcagt cgcggctgca ggagcatatc 1027801 aaagaaacaa gaacatacat gaaatatatg ctcaacgatc acctcgtcat tgttttgatt 1027861 ttttttctag cgggcgctgc aagctggtac agcaaatgga tacgggacat tcccgctcac 1027921 tttccgtcct tttgggtgat ggccgtgctg ttttcgctcg tattgacaag ctcttatgtg 1027981 cgaacgcttt tgaaggaggc tgaccttgtt ttcttattgc ctcttgaagc aaaaatggag 1028041 ccttacttga agcaggcgtt tgtctacagc tatgtgtctc agctgtttcc gctgattgcg 1028101 ctgagcatcg ttgcgatgcc gctttatttc gcagtcactc cgggagcttc gctcgtatcg 1028161 tatgccgcgg tctttgtcca actgttgctg ctgaaagcgt ggaatcaggt aatggaatgg 1028221 cgaacgactt tccaaaacga ccgcagcatg aaacggatgg acgtcatcat tcgctttgcg 1028281 gcgaatacac tcgttcttta ttttgttttc caatctgttt atatgtatgc gcttctcgtc 1028341 tatgtcatta tggctgttct ttatctgtat atgtcttccg cagcaaaacg gaaaacattt 1028401 aaatgggaga gccatattga gtccgaattg agacgaaagc agcgtttcta tcggattgcc 1028461 aacctgttta ctgatgtgcc gcatttgcga aagcaagcca aacgcagagc ttatctcgac 1028521 tttttgctgc ggcttgtgcc gtttgaacag cgcaaaacat ttgcctatat gttcacccgc 1028581 gcctttttgc gttcgagcga ttatttgggc attcttgtca gattaacgat cgttttcgcg 1028641 ctgatcatta tgtatgtctc agccagcccg ctgattgccg cggttttgac tgtgtttgcc 1028701 attttcatta cgggcattca gcttctgccg ctcttcggtc actttgacca tctggcgctt 1028761 caagagctgt accctgtgca aaaagaaaca aagctgaaaa gctatttctc tctattaaaa 1028821 actgcactta gtattcaagc gctgctgatg tctgttgcat ctgcctatgc agccggcttg 1028881 accggttttc tgtacgcgct gatcggttct gccgttctga tttttgttgt tttgcctgct 1028941 tatatgacga ccaggctgaa aaagcacgga aagctgtgaa ctgaaaagag gtaatcaaat 1029001 gacagataat cagctgctga tgcaggaagc tttggaatgg aaaatgcatt ttttgcgaaa 1029061 ggattccatg tttgaacgct tttcgaagcg tgtccagacg aaggtgaatg aacggattcc 1029121 tgaaaaaatc catacggtcg tcaccgagag tgtgaaaaaa atggtagaag cgacaatggc 1029181 cggctctaat atcatcacct ataaaaagga tacaagtgca ctgtcgctca gtgaaaaaaa 1029241 cgaattggcg aaaaaaacga ttgtttctta tcaaaaagtg gcagctgctg agggagtcgg 1029301 caccggagcg ggcggcattt ttttaagcat tgctgatttt ccgctgctgc tttcaattaa 1029361 gatgaagtgt ttatttacct tgtcttccat ttacggcttt gatgtcaagg atgcacaaga 1029421 aaggatattt ttgctgctcg tgtttcagct tgcgttttcg agtgatgatg gccgtaagtc 1029481 gcttttttct gtcatcgaaa attgggagac ggagaaaaag agcatcgact ggagagtgtt 1029541 ccagcaggaa tatcgcgatt atatcgacgt cgtgaagctt tttcagcttt tgccgggcgt 1029601 aggagcggca gtcggcggaa ttgccaatta taagctgctt gctcagcttg gagaaacggc 1029661 aagacatgtt tttcatctga ggatattaaa ggaaacagcc ggagaataaa cactccggct 1029721 gtttttttat agctgatgat aggtgatcgc agcgccggca aggaccttgg ccgctgtcag 1029781 catggctttt tcgttgatat caaatttcgg atggtggtgg gaatagactc gctctggctg 1029841 ttcgggagcg gcgcctgtaa agaaaaaagt gcccttcacg ttttgtaagt aataagcaaa 1029901 atcctcgccg cccatttgtg gttcaccgtc aatgacctgc tgaacgccct cggtattctt 1029961 tgcggtgctc accaagtggt tcgtttctgc aggatggttc acaaccgctg gataaccctg 1030021 ttcataggtg tactcatagg acgcgccgtg catgctgcat attcctttta caaccgcttc 1030081 aatttctttc tccagaatgt cccggacatt ttcatcaaaa gaacgcgctg tgccgatgag 1030141 tactgcttgg tctgcgatga cattaaacgg attgtcggcg atgaaggagc ctgtcgaaat 1030201 gacggcggat tgaatcggat tgactttgcg gctgacaatg tgctgcaaag aggaaacgat 1030261 ttgcgaaccg attaggacgg cgtctttagt atcatgcgga tgagcgccgt ggccgccctt 1030321 tccgaagact ttaatcgtaa atcggtctgc cgccgccatt acggcgccgg ggcggcagag 1030381 aatagttccg agcggctcag ttgcccaaag atgagtgccg aatatcacat ccgtgttttc 1030441 gagacatccg tcatcaatca ttggctttgc gcctccagga taatattctt ctgcatgctg 1030501 gtggatcatc acaaatgttc ccttcagttc atgtctgttt tggtgaagga ccttggccac 1030561 tgcgagaaga gctgcggtgt ggccgtcgtg gccgcatgca tgcatgacac caggcacttt 1030621 ggaggcgtaa gggacatctt tttcatcttg aatggggaga gcgtcaaagt cggccctcaa 1030681 agcgactgta gggccgggtt cgcttccttc tatatttgct aaaacccctc taccgccaac 1030741 gtttgtgcgg attgggactc ctaacgattc ataataggaa gcaataaatg cggcggtttt 1030801 ttcttcttga aatgagagct caggatacat atgaaaatgg cgcctgatct caaccatttc 1030861 ttcaaaacag ccgtcgagct gtttgtttat ctctttctgc agtgtggata tggacaaagc 1030921 cgcttccccc ttttctatgc ttttccatga ttgtatagaa aaagtctgaa tatttcaact 1030981 catgctgttt taaagcatca tcacagctgc gagggttgtc accaaaaggc caatcgcgac 1031041 gggaatgaag ttttttctgg caagctcaaa aggatcaact ttgcaaatgg ccgcggcggg 1031101 aatcaaagcc catgggacca gtgttcctcc gcccacccag atggcagaga tttgtccgag 1031161 cgcggtcaga atagcgggat cggcatggag agcggacgaa aagagctttg cgatggagcc 1031221 ggcgagagaa atgccagaaa atcctgagcc gtcaaggcct gttatggctc cagcggcagt 1031281 taatgcagtg gcggcaagct cctttgacat aggcatcata tgggataaag caatgccaag 1031341 atcgttgaca atgccgtggg aacctttagg gagtgaagtg cccagtatgc tttcatagcc 1031401 tgagtcgcca agataaaaga aagcggcaat cgggatgacg gggccgaaaa ccttaaaacc 1031461 gaacttaaat ccgtcaataa aatagccggt gattttttca agccctttat gcttatacac 1031521 gaaaaaatga acggtaaaga ggatacaaat tgcagacccg ccaattaacg cggttgcatc 1031581 atttccttgt aggttaaaca agagcatgca ggcgatatct gcaagaaagg caagcggaat 1031641 caaaaaagcc agtatggacc gcaggcgttt tggcaagtac agcgagttgt cttgttcgcc 1031701 ggaaagaacg ggggaaaaag aagtgggatg ctcctgtttt ttgcgttcgc gctgaatcat 1031761 gataaaggca gcagttgttg ttgtcacacc cataatcagc acaagcggaa tactggccga 1031821 gacgacatca ccgactggaa tgcctgctgc atccgcagtc agctttggcg ccgcctgaat 1031881 gacaaagtct cctgacaggg caaaaccgtg tccgaataag ttcatggcca tggccgcggc 1031941 aagaggcgtc aaaccggcac gtgcggctgc ggggagcagg acggcgccga tcaaagcgac 1032001 acccggagaa ggccagaaga atagagaaat ggcgaacatc aggcctccaa tcagccaata 1032061 ggcagtcaca ggccctctca caaggcttgc aaagggagaa atcatcgctt catttatccc 1032121 tgtttttgtt aacaaatcac tcattgaaac gataaagcaa atgatgaaaa tcgtgggcag 1032181 cagttcgccg gccgcataga taaagctgtg gaataaactg ctgacagaag ctgaaagtga 1032241 atggctggcc catagcgata tgataaaaat gccgaataga gaaataaatg tcgtgtcttt 1032301 tctcagcagc ataaatagga taattgcacc gataaaaaac acatacagaa catggacagg 1032361 caaaatcccg acttccatca tcgatcactc cttccgctta cagattattc ataggcgggc 1032421 ggaaggtgcc gggacagagg ggagggttat gatggaagat gaacattgat ctgtttcagc 1032481 tgctcaatca gatgatgcct taatcctcta ttcgcttttt gcagatgttt tgggaagcat 1032541 tcaggagaaa aaatgacgca cccttcagca agccagtttt ttctataggc gatgatgctt 1032601 tccgatggct ctatatgagt tatcctcgtg ctgcatctcg tactcatcaa atccgaactg 1032661 aaaaccgcag cacgggcaga tttcatgaga atgattgcct tcatgatcat atggcggttc 1032721 agccaatcct taaacccgca gactgggcaa gtatgcttca ttttgctttc ctcccaataa 1032781 aataagctgc cggacatgcc ggcagctatt cgacagcgaa atatgtggtg acataggaag 1032841 gccgggagaa gatcgacgtt gtgtcaattc cggcagatgt atcgcgtttt ttgtgggctt 1032901 ctttgtaaga accggactgc tgccagtctt gaaaggcgct ttccgtttcc cacaaggtca 1032961 gaatgacata ggtgtcactg tcaagcggac ggagcactcg aattgcttca aagccaggct 1033021 cgttttcgac ttttcccgct ctgtttttaa atctgttttc aaacagcgga cgcccttcct 1033081 gagtaacggc aatattgttc aatactgcaa aaccgggatg tttgatctct ccgacttggt 1033141 caatgacttc ataagcgtgt ggtgcctgga aaacggtatc tccgtttgtt tcatgaatta 1033201 aaatggcgtt ttcctgcccc tgcatcaaaa ggatattttc tgagggatgc ttctgtacga 1033261 tcgtttttaa aaaatcggct gtcccatatg taatataaac cttcatatca gccacctcct 1033321 gcttgctagt atatcaaaac aatggtataa gtttctattg gcgagtgctt cgaacataat 1033381 tccaaacaat ttttcccata ctacctttag aaaggcgagg tgagttcatg tttaagataa 1033441 agaaaaagaa actttttata cctatcatta ttttagtgtt aactgctttt ctcgctttaa 1033501 taggatatat ttcaattatt tttctcggcc attatgtcat agatgaaaaa aagcttattc 1033561 ttcatgcttc ttcaaaaatt gttgatcaaa acggagatga ggttgcaagc ctgtatacag 1033621 aaaatcgcga gccggtctcg atcaatgaga ttcctaagca ggtcagagaa gcgtttatcg 1033681 ctgttgagga taaaaggttc tatgagcatc acggcattga tgcaaaatcc gtcggaaggg 1033741 cagtgtaccg cgatatatta gcaggcggaa aggtggaagg cggaagcacg atcacccagc 1033801 agcttgccaa aaatattttt ctgacacatg acaaaacatt tctaagaaaa acaaaagaag 1033861 tgatcattgc gattaatctt gaacgggatt acagcaagga caagctgctt gaaatgtatt 1033921 taaaccagct ttacttcgga cacggggttt acggcataca agcggcgtcc cactattatt 1033981 ttaataaaga agtaaaagat ttgactgtat ctgaaggcgc tgttttggcc gctattccga 1034041 aggcgccttc tacgtactct ccaattttgc accctgataa aaataaggag cggcgtgata 1034101 caattctagg tatgatgaat gaccaaggct atatcagtgc gaaagaggct gtcaccgcac 1034161 agggccggac gcttggactg catgtgaaga aacagtcgga aacaccttgg tttgacagct 1034221 acattgacct tgtgatcaaa gaggcggaag acaagtattc catttccgga gagcagcttc 1034281 ttcaaggcgg atacacgatc aaggtgccgc tcgattcgaa gctgcagaag acggcttacc 1034341 aggtgatgaa agagggaagc tattatcccg gaacagatca gaatgccgag ggaagcgcgg 1034401 tctttattaa taacaagaca ggcggtgtag aagcggccat cggcggaagg gattacacat 1034461 ccaaaggata taaccgtgtc acagctgtcc gccagccggg ttccacattt aagccgcttg 1034521 ctgtatacgg accggcgatg caggaaaaga aatttaagcc atattctcta ttgaaggatg 1034581 agttgcagtc ctacggagat tatacgccga aaaactacga cagccggtat gagggcgaag 1034641 tcactatgtc tgacgccatt acgtacagca aaaacgcgcc ggctgtctgg acgctgaatg 1034701 agatcggcgt cgaaacaggg aaatcttatt tgaaagcaaa cggcattgat atccctgatg 1034761 aaggccttgc tcttgctcta ggcggcttgg aaaaaggcgt ttcaccgctc cagcttgccg 1034821 gcgcgtttca tacatttgcc gcgaatggaa cgtatactga acccttcttt atctcgagca 1034881 taatagatga agacggagaa acaatagccg atcataaaga agaaggaaag cgggtattca 1034941 gcaagcagac gtcttggaat atgacgagaa tgctgcagca ggtagtcaaa aagggaacgg 1035001 ccacgtccgg cacctatcac ggcgacctgg cgggaaaaac aggttcaaca tcttatacag 1035061 gcgtctccgg cgcgacaaag gacgcctggt ttgcaggcta tacgccgaaa ataaccgggg 1035121 cagtctggat gggctatgac aaaacggatc aaaaccatta tttgaaagcc gggagctcat 1035181 acccgacgcg gctgtttaag gatattttga cacaggcagg agaaaccggt catgtgttca 1035241 caaagcctaa aaacgttaaa gaactggaaa gcccgattga gctgaagccg gtcaaaacac 1035301 tcacagccga ttacacattt aaagcagcgg ggctctttac tattgaatta aagtgggacg 1035361 ctcaagagga tgatcgggcc gtatacagaa tttatgtaaa caaggacggc gaggagacgc 1035421 ttcttgattc ggttgaaggg aagggaagct atgaaattcc ttatgccaac ttattttcgg 1035481 gcgcgtctta taaaattgtg ccttataata cacagacaaa aagagaaggg gaaggaaccg 1035541 attacgttca gccaaaattg ttttcctctt aatggaattc ggcgattttt tgaactttga 1035601 gctacatttc tataccattt gcctaaaaca aggtatagtg taataagtca agaaatacga 1035661 acgtatggtt gccgtatgaa aggtggaaat cagatgagta aacgagaaac gtttaacgag 1035721 acgtttttaa aagctgcgcg gggagaaaaa gcggatcaca cgcctgtgtg gtatatgagg 1035781 caagcagggc gctcacagcc ggaataccgc aagctgaagg aaaagtacgg attgtttgag 1035841 atcacacatc agcccgaact ttgtgcgtat gtcacaagac tgccggttga gcaatacgga 1035901 gtcgatgctg caatccttta taaagatatc atgacgccgc tgccgtcaat cggtgtggat 1035961 gttgaaatca aaaacgggat cggtcctgtg attgatcagc caatccggtc tctggcggac 1036021 attgaaaaac tcggccagat tgatccggaa caggacgtgc cgtacgtgct tgagacgatt 1036081 aaactgcttg tcaatgagca gctgaacgtc ccgctcatcg gtttctcagg tgcgcctttt 1036141 acgcttgcaa gctatatgat cgaaggcggc ccgtcgaaaa actacaataa aacaaaagcc 1036201 ttcatgtaca gcatgccaga tgcatggaat ctgctgatgt ccaagcttgc cgacatgatc 1036261 atcgtgtacg tgaaagcgca gattgaggca ggcgcaaaag cgattcaaat ctttgattcg 1036321 tgggtcggcg cattgaatca ggcagattac agaacataca tcaaacccgt gatgaaccgg 1036381 atcttttcag agctcgcaaa ggagaatgtg ccgctgatca tgtttggcgt tggcgcaagc 1036441 catcttgcag gtgattggca tgaccttcct ctcgatgttg tcgggcttga ctggagactc 1036501 ggcattgatg aagccagatc aaaaggaatt actaaaacag tgcagggcaa cctggacccg 1036561 tccattttgc ttgcgccatg ggaagtcatt gagcagaaaa cgaaggaaat acttgatcag 1036621 ggtatggagt cagacggctt cattttcaat cttggccatg gggtatttcc tgatgtcagt 1036681 cccgaggttt tgaaaaaact gacagcattt gtccatgaat attcacaaaa caaaaaaatg 1036741 ggtcaatatt cctaagcata tcttttggta tcttaatgat atcctgtcaa aatgtttgta 1036801 tcagatcatt aaagagggtg taaacagtga gtagaaagaa aatggggctt ctcgtgatgg 1036861 cgtacggcac gccttataag gaagaagata ttgaacgtta ttatacacat atcagaagag 1036921 gcagaaagcc tgaacctgaa atgcttcaag atttgaaaga cagatacgaa gcgattggcg 1036981 gcatttcacc gcttgcccaa atcacagaac agcaggcgca taatctggaa cagcacttga 1037041 atgaaattca ggatgagatt acgtttaaag cgtatatcgg actgaagcat atcgagccgt 1037101 ttattgaaga cgccgtagca gagatgcata aggatggcat tacagaagca gtcagcatcg 1037161 tgctggcgcc gcatttctcc acgttcagcg ttcagtccta caacaaacgc gccaaagaag 1037221 aggctgaaaa actcggcggc ttaacgatta cgtcagttga aagctggtac gatgaaccga 1037281 agttcgtgac atattgggtt gaccgagtga aggaaacata tgcgtcaatg cctgaggatg 1037341 aaagagaaaa cgcaatgctc atcgtatccg cacacagcct gccggaaaaa atcaaagaat 1037401 ttggagaccc gtacccggac cagcttcatg aatcggcgaa attaattgct gaaggcgcag 1037461 gcgtttccga atatgctgtc ggctggcaaa gtgaagggaa cacgcctgat ccttggctcg 1037521 gacccgatgt tcaggattta acacgtgatt tattcgaaca aaaaggctat caagcatttg 1037581 tatatgttcc tgttgggttt gtcgcggatc acttagaagt gctttatgat aatgattatg 1037641 aatgcaaagt ggttactgac gatatcggcg caagctatta ccggccggaa atgccaaatg 1037701 ccaagcctga atttattgat gctttggcaa cagtcgtatt aaaaaaatta ggacgttaaa 1037761 gaaggcgatg aacatgagtg acggcaaaaa acatgtagtc atcatcggcg gcggcattac 1037821 cggtttagcc gccgccttct atatggaaaa agaaatcaaa gaaaagaatc tgccgcttga 1037881 gctgacactt gttgaggcaa gtccgagagt cggcgggaaa atccagactg tcaagaaaga 1037941 cggctatatc atcgaaagag ggccagactc atttctggaa cgaaagaaaa gcgccccgca 1038001 gcttgttaaa gacttaggtc ttgagcattt gcttgtcaac aatgcgaccg ggcaatccta 1038061 tgtgcttgta aaccgcaccc tgcatccaat gccgaagggc gctgtaatgg ggataccgac 1038121 aaaaattgcg ccgtttgttt ctacgggtct gttttccttg tccgggaagg cgagagctgc 1038181 tatggatttc atcctgcctg caagcaaaac aaaggatgat cagtcattgg gagaattctt 1038241 ccgcagacgt gtcggagatg aagtggtcga gaacttaatc gagccgctac tatcagggat 1038301 ctacgcaggc gacattgaca agctcagcct gatgtcgaca tttccgcaat tttatcagac 1038361 ggaacaaaag catagaagcc tgattctcgg catgaaaaaa acaaggcctc aaggctcagg 1038421 ccagcagctg acggcaaaaa aacaagggca gttccaaact ctgtcaaccg gtttgcagac 1038481 ccttgtagaa gagatcgaaa agcagttaaa gctgacgaag gtgtataaag gcacaaaagt 1038541 gaccaaactt agccatagcg gctcttgcta ttcgctcgaa ctggataacg gcgtcacact 1038601 tgatgctgat tcagtaattg tgactgctcc gcataaagcg gctgcgggaa tgctttctga 1038661 gcttcctgcc atttctcatt tgaaaaatat gcactccaca tccgtggcaa acgtcgcttt 1038721 aggtttccct gaaggctccg tccaaatgga gcatgagggc acgggttttg tcatttcaag 1038781 aaacagtgac tttgcgatca cagcctgtac gtggacgaat aaaaaatggc cgcacgcagc 1038841 gccggaaggc aaaacgctgc ttcgggcata tgtcggaaaa gccggagacg aatccattgt 1038901 cgatctatca gataatgaca ttatcaacat tgtgttagaa gacttaaaga aagtcatgaa 1038961 cataaacggc gagccggaaa tgacatgtgt aacccgatgg catgaaagca tgccgcagta 1039021 ccatgtcggc cataagcagc gtatcaagga gctgcgtgaa gcacttgcat ctgcgtatcc 1039081 gggtgtttat atgacaggcg cttctttcga aggtgtcggc attcccgact gcattgatca 1039141 aggaaaagct gccgtgtctg acgcgcttac ctatttattc agctaaaacc tccgctttat 1039201 cgcggaggtt tttttgatgt gcaatggcaa tattgtgtaa aaaatgattg aattgaacag 1039261 caggttatga tacatttgca tatgtactta atgactaaaa tgttcaaacg gtcagtttcg 1039321 aggtgaatac aatgtcaata gatcgaaaaa agctcatttt ggaggcggct acaaagtctt 1039381 tcacgcagtt cgggtataaa gcgacgacaa tggatcttgt cgcaaaactt gcgaacgtgg 1039441 ggaagggaac catttatact tttttcaaaa acaaagaaga gctgtttgac gagattttca 1039501 ctactttatt aaaggaaatg aagcaaaaag cggatgaagc gatggagccg agccttccgt 1039561 tccatgaaaa tgtgcacaga gcgctgtttg ccattctgga gttcaggaaa acacatcagc 1039621 tgacgattaa aattttccaa gagaatgccg agattggtac aatggcagtt caggaagtga 1039681 tccagaaaat ggagcgatcc atcctgtctt atatcaaaag caagattgaa gacgggatca 1039741 aaagcggcgc aatcaagccg tgcgaccctg agctgacagc ctttgtgatg ctgaagcttt 1039801 atatcgcgct catttttgac tgggaaaaac aacacccccc gcttgataaa gagacaattg 1039861 cgggactgct tgaattgtat gttgtcaaag gattgtcagc gaactagata atcctttctc 1039921 tttgcaagaa aatgaccatt ttttatgatg agtcagtttt agaatggagg catcaggatg 1039981 aacacaatac gaagtcagtg gaaagacatc gtaacaagta aaaaattatt gattcccatc 1040041 atcgccattt tgtttgtccc gcttatttac agcggcgtat tcttaaaggc ttattgggac 1040101 ccgtacggca cagttgacca gctgcctgtc gttgtcgtca accaagacaa gggagcaacg 1040161 tatgaaggag aaaaacttca aatcggtgat gatctggtca aagaattaaa ggataataac 1040221 aactttgatt ggcatttttc caatgatctc gaccaatcgt taaaggactt attgaatcaa 1040281 aaatattatt tagttgtcga gattcctgag gatttttcta agaatgccag cactgtatta 1040341 gacaaaaatc cgaaaaaatt ggatctgaaa taccatacaa atgcaggttc taactatgta 1040401 ggggcaacga tcggcgaaaa agcgattgat aaactgaaag cctctgtttc aaaagaagtg 1040461 accgagcaat atacgaaagt tatttttgat aactttaaag atatcgcaaa aggtttgagc 1040521 gacgcgagca gcggcgcgaa aaaaattgat gacggcacaa aggatgcgaa aaacggaagc 1040581 gcccagctga aagaaaatct ggcgaagctg aaggaaagca ccgctaccat cagtgacaaa 1040641 acagcgcagc ttgcagatgg agcggctcag gtgacgagcg gcatccaatc acttgacagc 1040701 tcgctcggta aattccagga cagcagcaac cagatttatg ataaatctag tcagcttgca 1040761 gcaggatcag gcgagctgac aagcaagatg aatgaacttc ttgccggact tcaaaatgtg 1040821 cagaagggta cgcctaatct tactaacggg ttggatcagc tcaacagtaa agtccaagaa 1040881 ggttctgaga aagcggcaaa agcggaaaag atcattaatg cgctcgattt aacgaagctt 1040941 gaaactgctg taaacaatct ggaaaagtca gaaactgcga tgaaggaatt caaaaaacag 1041001 ctgactgact ttgaaaacag tttgaaaaac cgtgatcagg catttaaaaa tgtcatcaat 1041061 tcgagtgact tcttaacagc ggagcaaaaa agccagctga ttaattctgt tgagaaaaag 1041121 cttccgcaag ttgatgcgcc tgattttgat caaatattaa gccagctacc tacagctgat 1041181 cagctgcctg acatcgcaac gataaaaagc tctcttgaag acgtgaaagc gcaggtggcg 1041241 caggtgaaag ccatgccgga agctacatct aagctttata acggcgcaaa aacaatccaa 1041301 gatgcgattg acagattaac tgagggagct gataagatat acaacggttc tcagaagctg 1041361 acagatggcc aaactaaact gacagcgggc atcggtgaat ataataagca gttcgcaaaa 1041421 gcaaaagcgg gctcagagca attggtgaca ggaagcagcc aagtatccgg cggattgttt 1041481 aagctgttag acgggtctaa acaggtccaa agcggatcat caaaacttgc agacggatct 1041541 gcatcacttg atacaggttt aggcaagcta ttggacggca caggagagct gtctagtaag 1041601 ctgaaggatg cggctgacca aacaggagat atcgatgctg atgatcaaac atacggcatg 1041661 tttgcggatc cggttaaaac caaagatgat gccattcatt ccgttcctaa ctatggaaca 1041721 gggctgacac cttatatcct gtcaatgggc ttgtatgtcg gcggcatcat gctgacggtt 1041781 gtcttcccgc tgaaggaagc gtcaggacgt ccgagaaacg gttttgagtg gttcttcagc 1041841 aaattcaatg tcatgatgct tgtaggaatc attcaatcat tgattgtggc gacggttctt 1041901 ctattgggaa ttggtcttga ggtagagagc acgtggagat tttacgtgtt tacgatcatt 1041961 acgagtctcg ctttcctggc gataattcaa tttttggcta caacgatggg caacccgggg 1042021 cgatttatcg cagtcattat tttagtgctg cagctgggag cgagcggagg aaccttcccg 1042081 ctggaattgc ttccgaattt ctatcaggtc atccacggcg cattgccgat gacctacagc 1042141 attaacggat tcagagcagt catttcaaac ggtgactttg gctacatgtg gcagatggcc 1042201 ggcgtcttaa tcggcattgc cctcgtcatg attgcactaa gcattactta ctttacaatg 1042261 ttaagccgga aggaagaaac atcagaagaa cagccggctt cataaagaaa aagaacttgt 1042321 ttccttggaa acaagttctt tttttgttac atcccccatt taataagcaa tcctgtatag 1042381 gttaatccgc cgccaaaccc gaaaagcaaa acgatttgat cttttttcag cttcccggct 1042441 ttcactgcga gatcgagcgc caaaacaatt gaaaccgaag acgtgtttcc gtagtgctca 1042501 acactagtga gcgttttttc aatcgggaac ggtgtttttt cacaaattga ctcgatcatg 1042561 cgcaagttgg cgctgtgagg aacaaaccaa tcgagatcat cggagctgag tcctgcttta 1042621 tgtaaaagcc gttcaaattc gccagggacg gttcttgcgg cccatttata tacctcgcgt 1042681 ccgttttgca ccatttttcc ggaaccgaca agctgcacac cgtttatttc atttcgcagt 1042741 ccggcacgat acaaaatatc gccgccgttc ccgcttgttc cttgtacaga cgcaagaaat 1042801 cccggcgtct cttcatctcg ttctactaac agcgcacccg cggcatcgcc gaacagtacg 1042861 catgtcgttc gatcggtata atcggttacc tttgataacg tctctccggc gatgacgaga 1042921 attttttgat gaaggccaga tgtgatcaat ccatttgcca aatggaggcc gtatgtcagc 1042981 ccggcgcatg tcgcattaat atccagcgcg ccggtgcttt cccagccgaa atattcctgt 1043041 acgcggcatg ccgtactcgg aaaggcgtaa tcggatgtgg ttgtggcaac gaggatcata 1043101 tcgacatcat caagcgttcc tttataacgg ctcttgagat tcttcaccgc ttctatgcat 1043161 aaatcagagg taaattgatg ttcatccgca atccggcgtt ctctcattcc tgtgcgctga 1043221 acgatccatt catcagaggt atcaacgatc ttttctaaat ctgcattggt taaacgtctg 1043281 ctcggcgcat aggtgccgat agctgtaatt tttgcttttg acatatgaat cactccttat 1043341 ggtcagatta taacactaga tattagtatc tggtactaaa aagaaggttt ttttacaaaa 1043401 aaagagaagt gtagatagga atctatgaaa aagaaaaagg aggctgaaaa atggtcagtc 1043461 aagaagcagt agtctttttg gcattatccg gggctattgc gtttctgttg ccaatcgggc 1043521 tgattgtatg gtttaagcga aagtatggtg cctcgcttaa agtgtttttt attggcgctc 1043581 tcacgttttt tgtcttcgct cagctgctgg aaggcggcgt tcatgtttat gtactgcaag 1043641 tgaatgaaat gacgaaagaa gcgatgcagc atccattatg gtatggcatt tacggctgct 1043701 tgatggccgg catttttgag gagtgcggaa ggtatttgat gatgcgattt tttatgaagc 1043761 gccatcatac ttgggcagat ggtctggctt tcggggcagg ccatggcggg cttgaagcca 1043821 tcctgattac aggcttgtcc tctatctcac ttattgtata cgcatttgca atcaatagcg 1043881 ggacgtttga acagcttttg gtcaatggcg acgtcaaaca ggcgcttttg ccgatacagg 1043941 agcagctgct gcatactcct tcgtatgaat ggatgctggg cggaatagaa agaatcagtg 1044001 ccattgccgt ccagattggt ctgtctctgc ttgttttgta cgcggttaaa aaccgccggc 1044061 cgctgttttt gctgtattct attcttttac atgcactgtt taatgtcccg gcggttttat 1044121 atcaaagagg aatcatagag catgctgcag ctgttgaaat cattgttgct cttatagcgg 1044181 ctttatcagt ttattggatt gtaaaagcaa aaagggtgtt tcaataaaag gtccaagcag 1044241 cagcaatgcc cgcttggaaa aatgtgaatg gaaatattca ttaagcatgg gtcatcagaa 1044301 tatttctgat tcagtcttta gcaatgacag caagaatgtc tgtgtttttt acaagagaaa 1044361 caatggtgtt tctttttctt cttctcgcaa gggtcatggc attctttctt tttcttgcaa 1044421 tggtcgtgga aatctttatc gaaccactcg tcaaagaacc aaaaatcatc gaaccaatcg 1044481 tgacaacgac atttctgttc atgtgaatga cgacagcaca tagaaatccc tcctcttccc 1044541 atgctctcta cagcatatga gagattgata ggaaaagatt ggacgggtcc ctcgggaaaa 1044601 gagtatattt taagtagaaa ataaaaggag gaatgcccta tgacgtccgt acgtaaaacg 1044661 atggagctca ttaaagaact tgtatcgatc ccaagcccga caggaaatac atatgaggtg 1044721 atcaattata ttgaaagcct tttaaaagaa tggaaggtag aaacggttcg gaaccacaag 1044781 ggcggcttaa ttgcaacgct tccaggacgc gacacatccc ggcatcgcat gctgacagcg 1044841 cacgttgaca ccctcggcgc tatggtgaag gaaattaaag cggacggccg gctgaaaatc 1044901 gacttaatcg gcgggttccg ctacaactcg attgaggggg agtattgcca aattgaaacc 1044961 gcctcgggaa aaatgtacac aggcacaatc ttaatgcatc aaacgtctgt gcacgtatac 1045021 aaagacgcgg gaaaggctga gcggaatcaa gagaatatgg agatccgcct agatgaacct 1045081 gttcactgcc ggaaagatac ggaggagctt ggcattggcg tcggagactt tgtgtcgttt 1045141 gatccacgtg tcgagatcac atcaagcgga tttattaaat cgcgccattt ggatgacaaa 1045201 gcaagcgtcg ccttattgct ccgcttaatt catgaaattc aaacagaaga cattgagctg 1045261 ccgtatacaa cccattttct tatttccaat aatgaagaaa tcggttacgg cgggaattcg 1045321 aatattcctc ctgaaacagt tgaatatttg gcggttgata tgggcgctat cggtgacggg 1045381 caggcgacgg atgaatattc agtatcaatc tgtgtgaagg atgcgagcgg gccgtatcat 1045441 tatcagctca gaaagcattt agttcaatta gccgagaagc atcatattga ctataagctt 1045501 gatatatatc cgtactacgg gtctgatgcg tcagcagcga tcaaatccgg gcatgatatt 1045561 gtgcatggcc tcatagggcc gggaattgac gcttcccatg catttgaacg cacccataaa 1045621 tcatctcttc gccataccgc taagcttctg tattactatg tacagtcacc aatggtataa 1045681 gggggaggac caatgaagat ttataagctg aaaagcacat tcggttggga aggtgatgac 1045741 gggttgggag aacagctgat tcagcagatc cttgccggag aaaaaagcgc cacgtgcgcg 1045801 ccgaaatcat tgtattcaaa agatgaattg agggacgttt atcaaacagc gggtcagctt 1045861 gttaccgttt atgataaaca tgacaatcca agatgcaata taaaagtaac agatgtcttt 1045921 gaaaccacct ttggtgcgcc tgatatgagg ttagtcaaag gagagggcaa tggagaccga 1045981 attgaggagt ttcaagagga tcatcggatg gcatgggcgg aactgatcaa aagcggtgaa 1046041 ctggagctga atgaggatac tgttttgatt acagagttgt ttgtgcttgt taaagattaa 1046101 aaaagcctgc ggggcaagaa ccccgcaggc ttttcattaa ccagaaatgg ttgcgttttg 1046161 ttctgttttc gattgggaca taacagtttc tgctttcgca ggattaaaca tgccttccca 1046221 tttagacatc acaacggcag caagcgcgtt accagtcagg ttgacaactg tacgtgccat 1046281 atccatgatg cggtctacgc cggcaataaa ggcaagtcct tcagccggaa cgccgatggt 1046341 gccaagcgtt gcaagcaaga caacaaaaga agtaccaggt acggcagcca tccctttgga 1046401 tgtcaccatt aagacgagca caagcgtaat ttggtgccaa atcgtcaaat caatgccata 1046461 tacctgtgct aaaaagagtg cggcaataga ttgatagaga acggaaccgt ctaagttaaa 1046521 cgtgtaaccg atcggaatga caaatgaaac aatgcctttt ggacatccga ttttctccat 1046581 tttttccatg atacgcggaa gaaccgtttc agagctggac gtactgaacg ccagtaagat 1046641 ttcgtccttc atgtaagcaa ggaacttgaa gatgctgatg ccggcaattt ttgcgacaat 1046701 cccgaaaata acaattaaga agaaagcaag cgcgacataa accaatccga cgagctttcc 1046761 gagagagata agagaaccga gtccgaattt agacacagtc actccgataa gagcgaaaac 1046821 gccgaatggc gccactttca tcacaaggtt tacaacgtgg aacatggcat gggatacacc 1046881 ttcaaaaaag gctaatacag gcttgcctct ttcaccgatc gcggaaatac ccaatgcaaa 1046941 tagtactgta aagcagatga tggctagaag atccccttcg accaatgact ggaagaagtt 1047001 tgtcggcaca atatggagga acgtttccgc cactgattta ttactttgtt ctttttcagt 1047061 ttcaacatat tgactgatgt ccgatttttg agcttcgtgt atattaactc ctgtacccgg 1047121 atggaagatg tttgcaaggg ctagtccgag aataatggca aaagtcgtga tgatctcgaa 1047181 gtacagaatc gttctgaagc ctaatttacc gacttgcttt ccatttcctg caccggctac 1047241 accgatgatt aagctggaga caacaatagg aatcactatc attttgatta agcgtaaaaa 1047301 gagatccccg attggctgca ggtaagtagg caatgctggg ttgccatacc aaatgacgcc 1047361 aacaatgaca cctagaataa gtccaacgaa tatttgtgtg gctaatccaa acttaattct 1047421 tttcatagat tacctcccaa aaaacaaagt atcaacatat atcatgaata gacatatatt 1047481 taatctcact attagatcaa attataatag ataagaaatc aattcgtcta tagtaaatta 1047541 tatttcgaaa ataaagaata ttcaatgaca ttatgataat caccagaatt atctaaaaac 1047601 aggtgagctt tgacctaacc tgactattat ttcaaaatta agagatatgt gaaaaaataa 1047661 gaaaatccca cgcgtaaggc gcgggatttt cgctcattac aaatcgttta cttttataca 1047721 gtcattgcag atattaccat aacactcatg ctgctcttct atcttttttc cgcattccgc 1047781 acactttttc gaaggcaggt ttctaaaaaa ttctgtgatt ttccccagca taaccaatcc 1047841 ctctttcccc tttgtagtga tttcattgta atataacaga ttacaaaaat caataactgt 1047901 tttgatacaa tgtttaaaac atgctttttt caagaaaaat gggtatattg aaggaggacc 1047961 aatttttttg aaaagatagg aggacattat gaaagttaca gttatcggat gctatggcgg 1048021 ttttccggcc gcaaatgaag cgacgtcagg ctatttgttt cagtcaggtg attactctct 1048081 gcttgttgat tgcggcagtg ccgtattgtc taagctgttc ggatatgtgc cggcggaaaa 1048141 gctggatgcg gtcgttctgt ctcattatca ccatgaccat atcgctgata tcggaccgct 1048201 gcaatttgcc aagcaagtcg gttcgtttct cggcaaagga gagcatacgc ttccgattta 1048261 cggacatgat gctgatatag aacagtttca aaagcttaca tataaaacac atacaaaagg 1048321 gatcgcctat cagccggatc agccgctgac tgccggtccg tttacgatca cctttttaaa 1048381 aacgattcac ccggtgacgt gctatgccat gcggattact gacggcagcc acactgtcgt 1048441 ttatactgct gattccagct atcaggattc atttataccg ttttcgaaag atgctgattt 1048501 attgatctca gaatgcaatt tttatgccga tcaagacgga acaagtgcag gccatatgaa 1048561 cagcctggaa gctgggcgca ttgcaaaaga agccggagcg ggagaactgc tgctgacaca 1048621 tttgccgcat tttggcgtgc atgacaacct tcgcaaagaa gcgaaaaccg tttttaacgg 1048681 agaagtgaat attgcgaaat caggttttgt gtgggaagga taaaggagga gcaccatgtt 1048741 atttatagac aatcaaaata tcaatgatcc gcggatcaat cttgctatcg aggagtactg 1048801 tgtaaagcat ttagaccctg aacagcaata tttgctcttt tatgtgaatc aaccgtctat 1048861 tatcattggg aaaaaccaaa atacaataga agaaatcaat acaaaatatg ttgaggaaaa 1048921 cgggattatc gtcgtccgcc gtttatcagg cgggggcgct gtgtaccatg atctggggaa 1048981 cttgaacttc agctttatta ccaaggatga cggggacagc tttcataact ttaaaaaatt 1049041 cactgagcca gtgattcagg cgttacatca gcttggggtt gaagccgaat taagcggccg 1049101 gaacgacatt gtagtagatg gccggaaaat atccggaaac gctcagtttg caacgaaagg 1049161 ccgtattttc agccacggca ccctcatgtt tgattcagcc attgatcatg ttgtatcagc 1049221 attaaaggtg aaaaaggata aaattgaatc aaaaggcatc aaatcgatca gaagccgagt 1049281 ggcaaacatc agtgagtttc tcgatgataa aatgaccacc gaagaattcc gcagccattt 1049341 gcttcgccat atttttaaca caaacgacgt tggaaacgtg ccggagtata agctgacgga 1049401 aaaagattgg gagaccattc atcaaatttc gaaagagcgc tatcagaatt gggattggaa 1049461 ctacggccgc tcaccaaaat ttaaccttaa tcattcgaag cgttatccgg ttggatcgat 1049521 cgatttgcac ctggaagtca agaaaggcaa aatcgaggac tgcaaaatct tcggagattt 1049581 cttcggtgtc ggtgatgtat ctgaaattga aaacctgctg gtcggaaaac aatacgaacg 1049641 cagcgtcatc gctgatgtgc tcgaaggtgt gaatctcaag cattactttg ggaacattac 1049701 gaaagaggat ttccttgatc tgatttacta aggcaaaaca catcgtttga aagagcggtt 1049761 gtgtttttga aataatggag gcaggaggga ttcacatgaa agtgttttta atcggagcga 1049821 acggacaaat cgggcaaaga ctcgtctctt tattccaaga taatcctgat cattccatca 1049881 gagcgatggt cagaaaagaa gaacagaaag cgtctcttga agctgccggt gcagaagctg 1049941 tgcttgcgaa tctggagggc agcccggaag aaatcgccgc tgcggcaaaa ggttgtgacg 1050001 cgatcatttt cacagccggt tccggcggca gcacaggcta tgataaaacg ctgctggtgg 1050061 atcttgatgg agcggcaaaa gccattgaag ctgcggccat tgccggaatc aaacggttta 1050121 ttatggtcag cgccctgcaa gcccataacc gtgaaaattg gaatgaggca ctcaagcctt 1050181 attatgtggc caagcattat gctgataaaa ttctggaagc gagcggttta acctatacga 1050241 ttatccgtcc gggaggcctt cgcaatgagc ctggaacggg aactgtttca gcagcgaagg 1050301 atctggagcg gggatttatt tcccgtgatg acgttgcaaa aacggtcatt gcctctttag 1050361 atgagaagaa tacggaaaat cgggcctttg atctgacaga aggagatacg ccgattgccg 1050421 aagcattgaa gaaactatga cagtactgac actcagggct ttttgctctt gagtgttttt 1050481 ttctgtttct ctataatgga gaagaaagct tggcttcaat aatgaatgac tattcattca 1050541 cttaaggggt gggagaatga atcttgtttc aaaattggaa gaaacagcat ctgagaagcc 1050601 cgacagcatc gcatgcaggt ttaaagatca catgatgacg tatcaagagc tgaatgaata 1050661 tattcagcga tttgcggacg gccttcagga agccggtatg gagaaagggg accatttagc 1050721 tttgctgctt ggcaattcgc ctgattttat catcgcgttt tttggcgctt taaaagctgg 1050781 gatcgtagtt gttcccatca atccgttgta cacgccgaca gaaattggtt atatgctgac 1050841 aaatggcgat gtaaaggcaa tcgtgggcgt tagccagctt ttgccgcttt atgagagcat 1050901 gcatgaatcg ctgccaaagg ttgagctcgt cattttatgc cagacggggg aggccgagcc 1050961 ggaagctgcg gacccagagg tcaggatgaa aatgacaacg tttgcaaaaa tattgcggcc 1051021 gacatctgcc gctaaacaaa accaagaacc tgtacctgat gataccgcgg ttattttata 1051081 tacgtcagga acgactggaa aaccgaaagg cgcgatgctg acacatcaga atttgtacag 1051141 caatgccaac gatgtcgcag gctatttggg aatggatgag agggacaatg tggtctgcgc 1051201 tcttcccatg tttcacgtgt tttgtttaac cgtctgtatg aatgcaccgc tgatgagcgg 1051261 cgcaactgta ttgattgagc ctcaattcag tccggcatct gtttttaagc ttgttaagca 1051321 gcagcaggcg accatttttg ccggtgtgcc tacaatgtat aactacttgt ttcagcatga 1051381 aaacggaaag aaagatgatt tttcttcgat ccggctgtgc atttcgggag gcgcgtccat 1051441 gccagtcgcg ttgctgacgg cgtttgaaga aaaattcggt gttaccattt tggaaggcta 1051501 cgggctctcg gaagcatcac ccgtcacgtg ctttaacccg tttgacaggg gcagaaagcc 1051561 gggctccatc gggacaagta tcttacatgt cgaaaacaag gtcgtagatc cgctcggacg 1051621 cgagctgccc gctcaccagg tcggcgaatt gatcgtgaaa ggccccaatg tgatgaaggg 1051681 ctattataaa atgccgatgg aaacagagca tgcattaaaa gacgggtggc tttatacggg 1051741 ggacttggca agacgggatg aggacggcta tttttacatt gttgaccgga aaaaagacat 1051801 gatcattgta ggaggataca atgtgtatcc gcgggaggtg gaggaggtgc tgtacagcca 1051861 tccggacgtc aaggaggcgg ttgtcatcgg cgtgccggac ccccaaagcg gggaagcggt 1051921 aaagggatat gtggtgccga aacgctctgg ggtaacagag gaggacatca tgcagcactg 1051981 cgaaaagcat ctggcaaaat acaagcggcc tgccgccatt acgtttcttg acgatattcc 1052041 gaaaaatgcg acggggaaaa tgctcagacg ggcactgaga gatattttgc cccaataaaa 1052101 tgaaaaagcg aagcggttag cttcgctttt tcattttcaa tcctttgctt cttttttaat 1052161 aatatttagc agcgcctttg tatcattttt gcttaatttg tagtatgtgc catccttcaa 1052221 aaaaacggct tgctggctgc cgtcaatcca tagtctgaat gagtcatacc ggtctttatg 1052281 aaacttgatt gtcccttcgt aatcaggggc tgatgttttt tctgtcttca cctgttttcc 1052341 ctgattcata atatccagca tatctttgac gtgctgtctt ttttcaatct cgatatcttc 1052401 ctggccgctt gaagacagtg tgatcaaatc cgcgtctacc gattgataca catcgcctga 1052461 tcggctgtaa agataaaaaa atgcgataaa cacaagaccg attaccacga tggctgccac 1052521 tatttttttc atttgcatca ctccaaacat tgttagtttt cccagcgatc ggggtttcca 1052581 tgcttaaaag ggtggaaaag tgcggaacac agcttggttc taagaatttg aatttatgat 1052641 tacaatagaa gtaacgggtt gatgtgagga gtgaggcgtt atgcgcaagt ggattgcggc 1052701 agcaggactt gcttacgtgc tgtacgggct gtttttttat tggtattttt tcctgtcggg 1052761 tgattccgca ataccggaag ccgtgaaagg gacgcaggct gatccggctt ctttcatgaa 1052821 gccgtctgag ttggcagtgg ccgagcagta ttcgaatgtc aagaattttt tattttttat 1052881 cggggtacca cttgattggt ttctgttttt tgttctgctt gtcagcggtg tttcaaagaa 1052941 aatcaagaaa tggatcgaag cggccgtgcc ttttcggttt ttgcagaccg ttggttttgt 1053001 gtttgtgctt tcgctgatta caacattggt gacgctgcct ttagattgga taggctatca 1053061 agtatcgctt gactataaca tttccacaca gacaacggcc agctgggcta aggatcaggt 1053121 tatcagcttt tggatcagct ttccaatctt tacgctttgc gttctcgttt tttattggct 1053181 gatcaaaagg catgaaaaaa aatggtggtt atacgcctgg ctgttaacag tgccgttttc 1053241 gctgtttctg ttttttattc agccggtcat tatcgatcct ttatacaatg atttttatcc 1053301 gctgaaaaac aaagagcttg aaagcaaaat tttagagctg gcagatgaag ccaatattcc 1053361 ggctgaccat gtatatgaag tgaacatgtc agaaaaaaca aatgcgctga atgcctatgt 1053421 tacaggaatt ggggccaata aacggattgt attgtgggat acgacgctga acaaacttga 1053481 cgattcagaa attctgttta ttatgggcca cgaaatgggc cattatgtca tgaagcacgt 1053541 ttacatcggt ctggctggct atttgctcgt gtcgctcgcc ggattttatg tcattgataa 1053601 gctttacaag cggacggttc gcctaacccg cagcatgttt catttagaag ggcggcatga 1053661 tcttgcggca cttccgctgt tattgctttt gttttctgtt ttgagctttg cggttacgcc 1053721 tttttctaat gctgtctcgc gttatcagga gaataaggct gaccagtatg ggatcgagtt 1053781 gacagagaac agagaagccg ctgttaaaac gtttcaggat ttggccgtga cggggctgag 1053841 ccaggttgat cctccggtgc ttgtgaagat tttcagaggc agccatccgt cgatcatgga 1053901 acggattcaa catgcggaga aagaagagaa tgcgccggaa catcaggatg ctgacaaata 1053961 aaaagaagca ggtatggagg aacctgcttc tttttactat tattgtgcag ctgcttgtac 1054021 gttgattaac ccttttccat agtagaaaga gtttccaaga tatgttgcag tgctttctaa 1054081 acgatcacgg acttgcgcgt ttgtccaagt cgggtgctta gaaagaatta acgctgctgc 1054141 tccggcaacg tgaggagtcg ccatggacgt tccgttataa gcgccgtaag tgcctccagg 1054201 aagtgtgctt tggatggaca cgccaggagc catcacatca agctcagaac ctgcgctgga 1054261 gaatgaagct ctttggttgc tgctgtttac cgcacctact gcaatagtag aaggatattt 1054321 tgcagggtag ccgactgtgc ttgtgcttcc ggatgaacct tcgtttccgg ctgcggcagc 1054381 aacgacgata ccgctggaaa cggctttgtc aacgactgtt ttcagcgctg tagaaccagt 1054441 aggtccgcca aggctcatgt tgataacatc catattgttg gaaatggccc actcaatgcc 1054501 gttaataatc cagctatatt ggccgcttcc tgttgaatca agcactttta ctgcatataa 1054561 tgatgcgctt ggcgctacgc ccagaacacc gattgagtta ttaagagcgg caatcgtacc 1054621 ggctacatgc gtaccgtgag aactgccgtc ctggtatggg tttgtttcag aaggtacgaa 1054681 gcttgctccg cctctgacgt ttaagtcagg atgagaagag tcaattccgc tgtcgataac 1054741 agctactttt acgttagagc ctgtgtagcc ttgagagtga agagccggcg ctttaatttg 1054801 agaaatgcca taaggaacag attgcgcata ttcatgtgca atatgatctt cttccacata 1054861 tgcaacgctc ggatcttttt tcaattcttt tacagctttt tcatccaatg ttgctgcggc 1054921 cgcgttaaca tacttaaatt gcttttgaac ctttccgcct ttttcagaaa taacatcctt 1054981 tttcttggcg gaactcatgg cactcattgt ctgtttaaat ccgacaatgt atttcttttc 1055041 tgtactgctt tttccggcag cctgcgcaga catgttgctg aacgccatcg taaagattaa 1055101 cgttaacgca aacaacaagc tgatccacaa ttttttgctt ctcactcttt accctctcct 1055161 tttaaaaaaa ttcagagtag acttacttaa aagactattc tgtgaattta ttgtaataga 1055221 tggaataata ttttagtaga cccatttttt tgagatgatt ttatctctat ttaggtatat 1055281 catctctcgc tatttccgta gagactcgaa ataactattt tcatacagaa aagaacgaaa 1055341 atagacatga gtaaatgttc attatgctga aatgtcatgc ttttttaggt taaatgctcc 1055401 tgagtcccgg caaattcctg tcgaaaaaat tcgttcaaat gacctgcgtg tgcttccgtg 1055461 agaacaatgg atattatcgt gatatttttt caaagcatga tgataaaagt attctgaaaa 1055521 ataaacttta cagaaaaggg atagaatgaa aaaattattg agagggagga agaaataaga 1055581 tgaacattcg ccaagcaaag acatcagatg cggccgccat tgcgccgctg tttaaccaat 1055641 atcgggaatt ttatagacag gcatccgatt tgcaaggggc agaggctttt ttgaaagctc 1055701 gtttggaaaa tcacgagtct gttattttga tagcagaaga aaatggagaa ttcataggct 1055761 ttacccagct ctatccaacg ttttcttctg tgtcaatgaa aaggatatac atattaaatg 1055821 acttatttgt cgttcctcat gcgcgtacaa agggagccgg cggccggctg ctttctgccg 1055881 caaaggatta tgcagggcaa aacggggcaa aatgtttaac acttcagact gagcaccaca 1055941 accggaaggc aagaagcttg tatgagcaaa acggctatga agaggatacc ggatttgtcc 1056001 attattgtct caatgtgccg gcgaagtgaa aatggcggct tgatgatttg gttttttgaa 1056061 cgttcttcgg ttacgatata aatgaaaagg agtgtgccga atgtcaacgt tatttcaagc 1056121 cttgcaggca gaaaaaaatg ccgatgatgt ttcagtccat gtgaaaacca tatcaacaga 1056181 ggatttgccg aaggatggtg tcctgattaa agttgcttat tccggcatta attacaaaga 1056241 tggtctggcc ggaaaagcag gaggcaatat cgtcagagag tatccgctta ttttaggcat 1056301 tgatgctgcg ggtacggtcg tctcttccaa tgatccgcgt tttgcggagg gggatgaggt 1056361 gatcgcgaca agctatgagc tcggtgtctc acgtgatggc ggattaagtg aatacgcttc 1056421 ggtgcctggt gactggctgg tgcctttgcc acagaatctt tcgttaaaag aagcgatggt 1056481 gtacggaacg gcgggattta ctgcggcgtt atcagtgcat cggcttgaac agaacggtct 1056541 gtctccggaa aaaggcagcg tgctagtcac aggagcaacc ggcggtgtcg gcggaattgc 1056601 ggtatcgatg ctgaacaagc ggggttatga tgtggtggca agtaccggaa accgggaggc 1056661 ggctgattat ttgaaacagc ttggtgcaag cgaagtaatc agcagggaag atgtctatga 1056721 cggaacgctt aaggcgctgt ccaagcagca atggcaggga gcggttgatc cagtcggcgg 1056781 aaaacagctt gcctcgcttt taagcaaaat tcaatacggc ggatctgtcg cagtgagcgg 1056841 cttaaccggc ggaggagaag ttccggcaac cgtgtatcct tttattcttc gcggagtaag 1056901 cctgctcgga atcgattcag tatattgtcc gatggacgtc agagccgctg tttgggagcg 1056961 catgtcttct gatctcaagc ctgatcagct gctgaccatc gtggacaggg aagtatcatt 1057021 ggaagaaacg ccgggtgcgt taaaagatat tttgcaaaat cgcattcaag gaagagtgat 1057081 tgtgaagctt taacaggatc agcttgcaga gaatgttatt tttctgcaag cttttttgtg 1057141 gacaggatga tcagctgctg aactgctgtg tcgcgaaaca agattttcct gtaagccgaa 1057201 ctttctcttc tcattttaaa aataattggt gataatgatt ctcattccgt gttatactac 1057261 tcttggacat cttaaccata gaaactacca acaggagaga ctggaacata tgaaaaaaac 1057321 actgattatt cttacagttt tacttctttc tgtcttaacg gctgcttgct cgtcttcaag 1057381 cggcaatcaa aacagtaaag aacataaagt ggcggtaaca catgatttag ggaagacaaa 1057441 tgtgcctgag catccgaagc gggttgttgt tcttgagcta ggttttattg atacactgct 1057501 tgatctcggc attacgcctg tcggggttgc cgatgacaac aaagcgaagc agctgatcaa 1057561 caaggatgtg ctgaagaaaa ttgacggcta cacatctgtc ggcactcgct cacagccaag 1057621 catggaaaaa atcgcttcat taaaacccga tttaattatt gctgacacga cccggcataa 1057681 gaaggtgtac gatcagctga aaaaaatagc gccgacgatt gcacttaata atttaaatgc 1057741 tgattatcag gatacaattg acgcttcgct tacgattgca aaagcagtcg gcaaggagaa 1057801 ggaaatggag aaaaagctga cggcgcatga agaaaagctt agcgagacaa agcagaaaat 1057861 cagcgcgaac agccagtccg tgcttttgat cggaaataca aatgatacca ttatggccag 1057921 ggatgaaaac ttctttacat cgagactttt aacacaggtc ggctaccgat atgcaatcag 1057981 tacgtcaggc aatagcgatt caagcaatgg cggcgactct gtgaatatga aaatgacact 1058041 ggagcagctg ctgaaaacag atccggatgt gatcatcctg atgacaggaa aaacagatga 1058101 cctcgacgcc gacggtaaac gcccgatcga aaagaatgtc ctttggaaaa aactgaaggc 1058161 agtgaaaaac gggcatgtat accacgtgga tcgtgcggtg tggtctctgc gccgcagtgt 1058221 agacggggcg aatgccattt tggacgagct tcaaaaagag atgccggctg ctaagaaata 1058281 aaagaaaaga caggcaaacg cctgtctttt tcttatttga taaagccgga taagtggctg 1058341 ttgatattat agtcttttat ccgccatttt tcttctgcaa attcaatgtt gctgaggcag 1058401 gcgttgacga gacgggtgct ttgaagctcc gggtcaccgc cggatatttc tgtcagcagg 1058461 gcgtgaattg ccgcaccgtg cgccacgatc agcaccttct tgtttggata cgcctgattc 1058521 acttttgcca aaccgcccat cagcctgtca gtgagttctt ctaaggtttc catattcgga 1058581 tagatgttat ctggatagcg ctttgtccgt tcctccagcg gcatgccctc cgcgtcgccg 1058641 taatcgcgtt ccttaaaatc atccatctcg actatcggaa gatgcagata ttcattaata 1058701 atttccgcgg ttcttttcgc tcttttcagc gggctcgtca caataatatc ccaagaaaag 1058761 tcctttacat attctccggt ttctcttgct tggcgttcac ctgttgcgtt tagcgggata 1058821 tcggttttgc cttggcattt ttgctgcagg ttccaatcgg tttctccatg tcttactaaa 1058881 caaacggctg tcataaaatc cccttcctga ctttattcat atcgctatta tactaaatcg 1058941 aaagcgtgtg tcctatgaaa aagcctatgc aagaacttca aataataaag ccagtccgat 1059001 tccgccgccg cttccgatgg ctgcaacagc atattgacag tctggccgtc ttttcgcttc 1059061 ataaaacaat ctggttacca gagctgcacc tgatgcaccg tacggatggc caagagctaa 1059121 ggcgccgccg cgcacattga tttttgaaaa gggaatgccg agttcttgcg agcagacaca 1059181 aattttgacg gcaaaggctt cattgatttc aaataaatcg atatcatcag gtgttacatc 1059241 gtgtgtatgt aagagctgac gaatcgcgac aaccggtgcc gcgggcggaa agttggggtg 1059301 aatgccgctg acagcgctgc cgataaaccg aagcacaggc ttaagtccca gggctgctgc 1059361 tttttcttct tccattacca aaagagcggc tgctccgtct gctatgccac tgctgttggc 1059421 tgctgtgact gttccggagc tggtgtcgaa aaccggcttt gcacggggaa taatcgcttc 1059481 tattggccgc gttttcaaaa atgcttcgtc cgtctccaat tccccgagag caacaacttc 1059541 ttcacggtaa aatccttcat catgcgcgtt cctgctgcgt tgatggctga gaagcgcgta 1059601 ctcatcctgc atgcttctgc tgatggaata gcgtgcagcc gtatattctg ccgcaatgcc 1059661 catgtctgga tcgccgatcg catctggaga aaagcgagcc cgttctgaaa aaggggattg 1059721 gctgctgctt tctgagccgc ccgcgatata catcgtgccg gctcccgctt gaataaggct 1059781 gcaggcatag cgcacagctt caaggccgga gccgcactgt ctgtcaattg tcattccggg 1059841 aaccgataaa ggcagtccgg cttgaagggc tgacagtctg gccaggttgc cgcctctgcc 1059901 agtagcgttt ccgagaatga cctcgtcaac ttgatcctct agctttcggc tgagacagcg 1059961 gatgatggga gccgccaaat cctccggcag gaagggcttc agcagtccgt tttgatttcc 1060021 aaagatcgtt cgttttgcat caacaataac cgcattcatt tatactgtac actctcttcc 1060081 agccattttt tcactctgga acgggcaatt tttccgctgc tcgtttccgg caagctgtct 1060141 gcaaacaccc attttttcgg aattttatag gaggctaatt tctgtttaca ccaggctttc 1060201 agtgttctgg cattagcgtt tccaagaatg acagctacag cgatttctcc ccaatactcg 1060261 tcgggaatgc caacgacagc cgcgctttca acctctgggc aggcgagaag cacacgttca 1060321 atttcttctg ggaaaatatt taatcctccg tacacgatca tcccgttttc tcttcctgat 1060381 atgtatagaa agccctcttc atcaacgtag cccatatcat ctactgtcat ccattcatct 1060441 ggtgtgctgc cgttcacata gccggaaaac ctcatcgggc ttttgacaaa tatttttccg 1060501 atttctcctg gctggcagcg ttctcctcca gcgttgcgga tttcgatccg gacattatga 1060561 aaagggcggc ccgctgaatg cggcttccgt ttgctgtctt ccggtgaaga aaacgtcaca 1060621 aaactaagct ctgatgtgcc gtaaaaatcg tacagcttga gatgaggcca tgcagcggca 1060681 agcttcttct tggattctgc cggccagtct gcgccggatg aaatgatttt gacgggactg 1060741 tcgggaaaac cctcaatcct tgcgagggcg tctgtcatcg tcggtacggt atagagaaca 1060801 ctgatggatt cacggcacag ccattccttc gctttggcag gagaaaactt tttcagcaaa 1060861 caaacggttc ctccgagaaa caaagtgctg acagccccat ataggaagtg agaggacatt 1060921 aacgctccgg gaatcagaac cttatcatct gatgaaatcg aaaaatctgt ttctgtacag 1060981 gtaaagctct ccatccatga gcggtgagat cgcgtaaagg ccttcggttt tcctgtcgag 1061041 cccgacgtaa atcccatata aaaagggtgc tccggatcaa tggtaggcaa gggatcagcg 1061101 gctgcctcag aaatatctgc catacagtta tccagcaata caacaggtgt ctggctatct 1061161 gtcagtttgt ttttgaaaaa ggctaaagta accacaagat ccgcattgct tatggacagc 1061221 cgctccttac attcagccgg gctccagcgt gtgtcgatgg gaatggccgt acatccagcc 1061281 gctgcggctc cggcaaacag ctgtaaaaac gcgagactat ttgggagcag gatcgccaca 1061341 cgattcggca tgctcggctg tgaccgcagc caatttgcgg tttgagagac aagccgatcc 1061401 caatcatggt acgtgatttg ctccgattca gtctggatcg ctacacggcc gggcgatgtt 1061461 tcggcagtag atgaataggt atgagtaatt gtcatgtatt gtcatcctcc ttttgtaaac 1061521 atcgtatcag aaagagacaa ggcttgagtg atttttatcg ccagaaatgc agatacagcc 1061581 gcttttatca aatcaccagg cacatatgca aggctcatga aggcggcctg tgacaaatca 1061641 atatgcatga taaaagcttg taccggtata ccaagcagat aaataaagat gatgccgaat 1061701 acgatatgag tgaaaaagag acgcaatact gtcaccttcc gcagcctgtt agcggctaaa 1061761 ctgatcagcc atgaagcgag gggataagca atcaaaaagc ctgcgctcgg tccgaaaaac 1061821 acaccaaaac cgcctcgtcc gccgggcaac agcggcgctc cgaaggcgac gagcagcaaa 1061881 aagacaagct ggcttaagaa agcagacttt ggcctgagaa tgctgcctgc caacatgaca 1061941 ccaagcgttt gcaatgtaat cggaacgggt gtaaaggata agaagagagg gggcataaag 1062001 ccgagcactg ccatcagcgc ggtgaaaatc gcaatatgca tcatgtcgat taatttcagc 1062061 atgtgaaatc ctccaaaaag taatcaaata tggttataca ataaatgcag gtaattatta 1062121 tgtcaactga tttttaattt aagtttacat aatgaacgca aaaaaaccgg ccgtatggca 1062181 gaccggtttt tgatggttat tcttctgtca ggatgacaag cgaatcaacg gaagcggcca 1062241 catgggaaac ggcgcggctg acttcctgaa gccctccaag aaaggcttgc agatcgacgt 1062301 cgattttgcc tgattgctct ttgctgattt tcatgctgtg gacgatttca tcgaataagc 1062361 ggttaatttg cgtcattttt tctttacttt cgctgactag ctcattcacg tctttgatat 1062421 gcttggatac aatgttgatt tgtgtattcg tattgttcac aagctcagaa acagtagaga 1062481 cggttttttt cgtatcctca gaaagcttcc gcacttcatt tgccacgaca gcaaagcctt 1062541 tgccgtgttc tccggcgcgg gcggattcaa tagatgcatt gagcgagaga aggtttgttt 1062601 gttcagctat gcctgtgacg atgccgaaga ttttttcaat ttgctgcgcg atttcatcca 1062661 gcttgaccat ttctttttcg atttggacaa ggcttgtgtc aattttgttc atctgttttt 1062721 gctggacttc tagctctttt tttccgccga tcgacttttc ttcaacagtg ctggatgtta 1062781 cagtgccggc tttggatgct tgagaaatgc cttcagattt gtccacaagc tcttgaactg 1062841 atctgcttgt ttctgaaaac agattggcaa tcgatccaga ggtttcttga attttctgat 1062901 gaagaaggtt tttcttttct tcttgttcat cacgggtctg gttgtactcg ctttgaaacg 1062961 cttcaaggac aagctgctgt tctaagttca agatttttgt tgttgcttta atggctttta 1063021 gcagttcttg ctgatttgta atggacgctt cataaatgtc aatcattgac aaaaggagct 1063081 cttgaaacgc acccatatac cattttggca aaaggccgat tcttaaatgg atggaggcga 1063141 ttcggttacg cttttcaata aattcatcat cgataacgcc tgcaaacatt tcctgaatat 1063201 gccgttttaa cgtttgtttt aagcggtcaa ctgagctgtg atcattaatg atatccatca 1063261 atgagctttc atggtcaagg tttttataaa acgcatcgac gatatttacg atattttctt 1063321 gaatgagtgg ctgaagctgc tctaacacat aaagctcagc atctcccaac ctgaccattt 1063381 tgagctgttt tttgacatct gcatgtttgt ttgtgagctg aatgcggttt ttttgttgtc 1063441 cgtttgaatc tgaaaagtaa gctgtttctt gttttctgtc ttttttaaat aacaatacaa 1063501 tgatccccct tgggaaaaat ataattttta ctttttggct ttttaagcct ttttcttttt 1063561 tatcggccaa gggaaacatg aatgaagctg cagatgaaaa atatttgaaa aaacgttcat 1063621 taaaatgaac ggtttaatcg agatctattt gttttaatgg tttaatggcc ggaccctcta 1063681 caacttcgcc agatggctta aagcgtgatc cgtggcacgg acaatcccac gtatgctcac 1063741 tgtcgttcca ctcgacctcg cagcctaaat gggtacaagt cgtatcaacg agatggaggc 1063801 agcctgtctc atcacgaaat gctcccgctc gcctgccgtt tatggtgacg gctttccctt 1063861 ctcctggcga aatgtcttca aattggacat caggcttttc aagctttcct tttatcaaat 1063921 gcttggcgac atctgcattg taggaaatca ctttctgcaa cccgggattc agatggaaac 1063981 gggacggcgt gaaaatgctt tcgtatgggt tttctttttt ctccacaagg tctgacaata 1064041 aagtggctgc gactgctgag gacgtcatgc cccatttttt gaacccggtc gctactagaa 1064101 tattgtcctc attttccgac atcggcccga taaacgggat tttgtcgatc gtcactagat 1064161 cttgggtgga ccaataatat ggaatgcttt cgatgccgat ggtgctttcg gccagttgtc 1064221 tcagtgtttc ataatgtgta gacatggctt ttccctggcc tgttttatgg cttactccgc 1064281 tgaagagaat cagcttttca ccgtttacaa ccgtatagcg gagcgccact gacggctgat 1064341 cgatactcaa atacatgccc tcgggatact cgatcttcgg cttgatggca aggacataag 1064401 atctgtcgga gtacattctc gcagcatata atccgcctcc gtcataaaaa gggaagtggg 1064461 aacagcatat gataaagcgg ctcttaatgg cgtgccggct ttttgttacc acttcgggcc 1064521 tttcgccttt tttgatatca agcgcaacgg tctcttcata aattcggccg cctttttgaa 1064581 caatttgctc cagaagcgct tttaagtatt gaagcggatg aaattgagct tgattcttca 1064641 tgacaagcgc cagcttagaa cctaagggaa ttggaagatc cttgataagg tctctttcaa 1064701 ttccgagctt tgtgtatgcc tcatgctcgg tgtggatttt ttgaacagcg ttttcatttg 1064761 ccgtataaag atatgcgtct tgctcgatcc attcacaatc aatttgatgt tcatccacaa 1064821 tgccttttat gtaatcaatt gcgttttggt ttgcttcata ataaagcctc gcatggttta 1064881 atccgaaatg gcggataaat tcgtcgtata tcatgtcatg ctgtgcggta actttagcag 1064941 ttgtatgcgc agtggttccg ttaagaacct gatttgcttc aatcaaaacg acacggaagc 1065001 ctctcttcgt aagttcatat gccgttgtga ttcccgtaat cccgcctccg ataatggtga 1065061 cgtcacattc agtgtcctct tgaagcgcag gaaaagaagg caggtcagtt gatgttttcc 1065121 agtatgtttc aggtgcttcc tttgcaaaat gttgattagc caagccgtta tacctccaat 1065181 cagatttatt cttaattttt ccatattcta tcttttcata cataggaagc aggcattgtt 1065241 cataacataa taaggttgaa aaggagtgat ttcattggcg aatcaaaaaa agaaaacatt 1065301 accgcctcag caccagaacc agcagcctgg ttttgaatat ctgatggacc cgcgtccggt 1065361 ttttgataag ccgaagaaag cgaaaaaatt agagggcaaa accgctatta ttactggagg 1065421 agacagcggg attggacgcg ctgtctcggt gttattcgca aaagaagggg ctaatgtggt 1065481 cattgtgtat ttgaatgaac atcaggacgc cgaggaaaca aagcagtatg tagaaaagga 1065541 aggggtaaaa tgcctgctga ttgcaggaga tgtcggggat gaagcgtttt gcaatgatgt 1065601 ggtcgggcag gcaagccaag tgtttccatc cattgatata ttggttaaca atgcagctga 1065661 gcagcatgtc cagcccagca ttgaaaaaat caccagccac cagctgatca gaaccttcca 1065721 aacaaacatt ttttccatgt tttacttaac aaaggcagtg ctgcctcatt taaaaaaagg 1065781 gagctctatt attaataccg cttcaattac cgcctataaa ggcaataaaa cgctgatcga 1065841 ttattcagcg acaaaaggcg cgatcgttac gtttacaagg tccctttccc agtcgcttgt 1065901 tcagcagggc atacgggtca atgcagtggc accgggtccc atttggacac cgcttatccc 1065961 ggccagcttt gccgcaaaag acgtggaagt gtttggttca gacgtgccga tggaacgccc 1066021 ggggcagccg gtcgaagtgg cgccaagcta tctatacctt gccagcgacg attccacata 1066081 cgtcacaggg cagacgattc acgtcaatgg cggaacaatt gtgaacggat aataaaaagc 1066141 caatccttga aggattggct tattcgctct gcttgagcgc tgcatattct ttagagagcg 1066201 taagaaacgc atctttatct ttttcgtcca aggctttgtt aatttggtcc gtcagcatgg 1066261 caagccgacg gttatacaag gattcatcga gcaccatttg aatgtaaata tccgtcattg 1066321 tgacatcgaa ttcttttgtt ttttgcgtgt tgcgggactt catgagctca gtgtacgatt 1066381 ttttctcttt cataaagaat ccccccaatg ccttttttat agtatatgga taacggtcga 1066441 aaaaatcaat aaatttttat aatttttaga caactaatac ttggcaatct atcgacatat 1066501 cctgcaaaat gccgtaaacc ggcaagtctt atgaaagtaa aatcggttta ttactagtca 1066561 tttagtacca ttaaatatca ttaaaagatg attttatctt aaatgttaaa aaaacctgtc 1066621 gttttacaaa aacagatgat agattattag tataaatttt gcagaaaaag gatggaggcc 1066681 ataatatgag tcagaaaaca gacgcacctt tagaatcgta tgaagtgaac ggcgcaacaa 1066741 ttgccgtgct gccagaagaa atagacggca aaatctgttc caaaattatt gaaaaagatt 1066801 gcgtgtttta tgtaaacatg aagccgctgc aaattgtcga cagaagctgc cgattttttg 1066861 gatcaagcta tgcgggaaga aaagcaggaa cttatgaagt gacaaaaatt tcacacaagc 1066921 cgccgatcat ggtggaccct tcgaaccaaa tctttttatt ccctacactt tcttcgacaa 1066981 gaccccaatg cggctggatt tcccatgtgc atgtaaaaga attcaaagcg actgaattcg 1067041 acgatacgga agtgacgttt tccaatggga aaacgatgga gctgccgatc tcttataatt 1067101 cgttcgagaa ccaggtatac cgaacagcgt ggctcagaac caaattccaa gacagaatcg 1067161 accaccgcgt gccgaaaaga caggaattta tgctgtaccc gaaagaagag cggacgaaga 1067221 tgatttatga ttttattttg cgtgagctcg gggaacggta ttagaaaaat aggaaggagc 1067281 tgaccgaaca gggcagctcc tttcataaag ctatgccgtc ggaattcctc cggtgatgcc 1067341 atatacctga gatgtcacat agcttgaatt ctctgaagct agaaatacat aaacatcggc 1067401 caattccact ggctgcccag cgcgatttaa tggagctggc ggcgtgcctt gtccgaattt 1067461 cgggatgttt tccgtcggct gtccgccgga aatttgcagc ggtgtccaaa ttggtccggg 1067521 cgcaactgaa tttactctga tgcctttgga agcaagctgt tttcccagtc cgacggtaaa 1067581 gccgataatg gcgtttttcg ttgctgcgta atctaacagc atcgggcttg gattatagcc 1067641 ttcaactgag gtagttgtga taattgaagc tccctccggc aaatacggaa gcgccgcttt 1067701 tacaacccag taaagggaaa agacgttcac ttcaaatgtt ttatagattt gttcagtagg 1067761 cagatcttcg atgttttcga ccgcttgctg tttgcctgca acgagcgcta gcacatcaag 1067821 tccgccgagt tcgtgatgcg actgtttgac tagatcttgg caaaaggatt cgtcgctcaa 1067881 gtctccgggg atcagcactg cttttcggcc ttctgcttca atcagctctt ttacctcttc 1067941 agcatctggc tgttcctcgg gcaagtagtt aatagccaca tcggcacctt ctctggcgta 1068001 agcaattgcg gcagcgcggc cgataccgga atcgccgccc gtgacaagcg cttttcgacc 1068061 cgttagttta cctgatcctt tgtagctttt ttctccgcaa tcagggacag gcttcatgtt 1068121 cttttgcagg cctggcggtt cttgatattg ttcgggaaat tcatcatgaa aaaatgcttt 1068181 tataggattc gtaagatttg aatcagacat cagcaacgct ccttttctgt ttggtgtaca 1068241 ttcgtatgtg tacccctgag cataagcaga aaaacatgtt ttggcagttt gaatagtgaa 1068301 ggaaaaagaa aacaagaaaa aacaaagcct tcttccatat ttatcttgtc aaataagact 1068361 atatgaatta tgataaattc gagctataaa tcaactaaat attgggtgtt gggagagtga 1068421 atcgtcatga aaaaagcggc ggcggttttg ctgtcactcg gtctcgtttt cggtttttca 1068481 tacggagctg gccatgtggc ggaagccaaa acaaaggtga aggtctataa gaactgcaag 1068541 gagctaaaca aagtatacaa aggcggagtg gcccgcacat cgaaggtgaa aaacaaaggc 1068601 ggaaaaacga agtacaagcc ttacgtttct aaggcacttt acgatgccaa taaaaacaaa 1068661 gaccgcgata aagatcttat cgcctgtgaa cggtaaataa gaaaaagcaa tctggtgtcc 1068721 agattgcttt ttttatgctt aggccgcctg atcggccgca gcgcttttcg ccttccttgt 1068781 cataaggctg actgccatca tgaccgtgat attcaaaagc agggcgacga tgccgacatt 1068841 caagtctttt gcggcttgcg gcagagccgg aaataaagtg ccgatcgtcg tttccgtcat 1068901 tgtaatataa gtaactgctc cgacacctgc aataatgccg gcgaaagctc cttgctttgt 1068961 caccatatta tgcttgagca ggctgaacaa aagggcgggg aatagctgtg tgacaaggct 1069021 gtagcccatc aaaagcagcg taacgatggt attcccgcct ttgaaggtaa aatacaccga 1069081 aatcagcgca atcaccggca ctaaaaactt agcaagcgcc gatacttgct gttctgtcgt 1069141 gcggggcgcg attaccttgt acacattttt tgcaaacagt gtggaggcgg acattaagat 1069201 catagaccct ggcacaagtg ctgtcagcag tccggcagca ccgataattc cgacaaacca 1069261 agggtcaaat gcttgcagag acagtctcaa aagcgacaaa tccccgtctg cgccattcag 1069321 atctggaact tgcaggatag ccgcaaagcc gacgaaaagg acgaagagca ggaccagctg 1069381 gtacaaaggc atgatgatgg cgtttttacg aaacactttt gggttttcgg ctgaatacga 1069441 agcggaaaac gtgtgaggcc acatgtaaaa accaagcgct gtcaagagta cggttgaact 1069501 gaaccaggcc acactttgtc ccgattcggg gagcgtaaga aagccaggct ttgccgtttc 1069561 aatctgctga aacatgtctt gaaatccgcc gtagtaatga attggcaaat acacacctaa 1069621 aaacagaacg acaaccagaa tcatgatgtc cttcacaacc gatatccagg cagacccgtg 1069681 aatgcctgaa accataacat aaaccgtgat ggaaacagcg ccgatccaga tggcagcggt 1069741 cggggtgatt ttgccgtacg aggtttccga tacaatcagc ccgaggcctt tcagctgcag 1069801 tacaagatag ggaatgagtg cggcgatgcc gaccagtgaa acgagaatgc caagcagcgg 1069861 actgttgtat ttttttgtga aaaaatcaga ctgcgacatc agtttatgct gtttcgcgta 1069921 cgtccaaact gctggaagaa gccagtaaga aaggatgtag gccagacatc cgtaggcgat 1069981 gatataaaag gctggaccgc cttttccgta ggcccagccg ctgccgccga gaaacgtaaa 1070041 agtagtataa atttcgcctg ccatcaaaag gaagacgaaa acagttccga agccgcgccc 1070101 tccgaccgtc cactgctcca ggttcatgtc ttttcctttt tgggcgcgta taccgagaaa 1070161 aatactcaag agcaggacac cgaagatgat gatgagagct gcattcattc tgcttcctcc 1070221 tttttatttt ccttgtcgag gacatacaca atcgccatca gcgcagaggt caaaagagcc 1070281 cacatcacaa tataggcaag aataaacggc atgccgaaca catagggggt caccttattt 1070341 gcaaaaggga tgccgagtaa gattccgata aagggtaaag cggcaagaac gtgaatcagt 1070401 ttcatagaat cctccttcta tttaggattg aggtgtacaa gcctaagcgt actgaaaatg 1070461 atgtcgcaga tatcgcagca catgtcattt tttggagtga aaggctgtgg ttcgaattat 1070521 aaataaattt attttgtttg tatagtgtga attgtctgaa attaatgctc tgaatcgccc 1070581 gaagagggaa cgggcagtat gattcaaaag gctcagagtc tgtctggggc aaatagatag 1070641 tatgttaata attcgctgac ctgctcacgg attcgcggat taaaatagcg atggttttct 1070701 tcataaccgt cgatgacaaa tgtatagagt gtaaaggcct catcgcgttc cgtctcgcgg 1070761 attgcaattt ttcttttcct cagttctttt ctgacctcca tcaaatcctt ttgtgctatt 1070821 tttaatgatt cgctgataag ctgtttataa ggatgcttca attttaatgt gctttcttca 1070881 attccggcga gatcacggtt aaaaatcgta atggccatgg gcaaaaagag agcccgttca 1070941 attaaatcgt atatttcctc ctgcagattt ggcatattga ctccttcttt ctaagggaac 1071001 gtttgttcta tttgtattct atatcggctg gtgaaatgtt tcaagacaga aaaaatcacc 1071061 aaaacttttt agttttctgc tgataatgtg tagaataagg atagacaaac ccggtaagga 1071121 gtataaatgt tggagcattt tttatcctat ttgacacaag aacatttaac tgaattattt 1071181 caaagctata gggctttcgg tccgctcatt gctgtgctgc tgcctttaat tgaagcattt 1071241 ctcccgtttt tgccgctgat cgtgtttgtg gtggcgaata cgaactcgtt tggcttgtgg 1071301 gaaggattca tcctatcctg ggcgggatca actgctggtt ccattctcgt ctttttgatt 1071361 gtccgtcaat acggacagag aaaattgctt ggatttatcc gcagtcatcc gtctgtcaga 1071421 aagctgatgt tatgggtgga aagacacggc ttcggtccca tgtttcttct gctttgtttt 1071481 ccatttacac cgtcagccgc ggtgaatgtt gttgccggtt tgtcaaggat cggaacgcgg 1071541 ccgtttattt tggcggcagc ctcggggaag cttgtcatga tttttatgat cagcttcatc 1071601 ggatatgatc tgcacgcgct gattacacag ccgattcgaa cggtcatcgc cgtattggtg 1071661 atcactgtct tatggtatgt cggcaaaaag gtggagcggt atctgcatgt aagagccagt 1071721 cagcgtgagc atgatggagg gagacagtaa catgaaaaaa cggttttggt ttcttgccgg 1071781 tgtagtgtcc gttgttctcg ccattcaggt taaaaatgct gtctttattg attacaaggt 1071841 agaaggcgtc agtatgaacc cgaccttcca ggaaggaaac gaattgttgg tcaataaatt 1071901 ttcgcatcga tttaaaacca tccatcgttt tgacatcgtc ctttttaaag gccctgatca 1071961 taaagtgctg attaaacggg taatcggctt gcccggtgaa acgatcaaat ataaagatga 1072021 tcagctgtat gtgaacggaa agcaggttgc tgagccattt ttgaagcatt tgaaatctgt 1072081 ttctgccggc agccatgtaa cgggtgattt ttctttgaaa gatgtgacgg gaacaagcaa 1072141 ggtgccgaaa ggaaaatatt ttgtcgttgg agataatcgc atatacagct tcgacagccg 1072201 gcattttggt ccgataagag aaaaaaatat tgtcggtgtg atttctgatg ccgaataaaa 1072261 agacgctaat tgaagaggcg tctttttgta tgccgtttgg aaaaatgtgt tgaagaaaaa 1072321 tttgtaagga gctataatca aaattgttac ctgtgtaaca aaatttatat atttttttga 1072381 ctggagggcc gtttttattg gtttttgttc gtttttcatg aaacaaaagg agtggtgaat 1072441 gatgatgaaa tatgaagcag tgattatagg aggagggccg gttggattta tgctggcttc 1072501 tgagcttgca atagccggag tgggaacatg tgtgattgaa cggcttgaaa aacctgttcc 1072561 gcattccaag gcgttgacgc tgcacccccg aacgctggag cttcttgaga tgagagggat 1072621 tttagagcgg ttcgtatcca agggaagcaa gatacctacc ggacattttt caatgctgga 1072681 tacccgtctg gatttttcag gcttggatac gagctgtcct tacacgcttt tgctcccgca 1072741 gtccaaaaca gaaaagcttc ttgaagatca tgcacgaagc ctgggaacag aggtgtttcg 1072801 gggtgccgag gcgctggcgg ttacgcaaaa cggggaagcg gtccaaacaa tttttaagga 1072861 tcgggacggc agtgtacgga cgatcacaag caagtttgcc gttggggcag atggcgccgg 1072921 gagtaccgtc cggaaacagg cgaaaattga gtttccggga acagacagca ctgtcaccgc 1072981 tgcgcttggg gatgtggtgc tcctttctcc gccgccgtca ggtgtgctgt ccctttgcac 1073041 aaaagagggc ggtgttatga ttgttccgtt atctccagac cgataccgtg tcgttgtgat 1073101 cagcccttat cgcacacaaa cgccgaaaga tgtgcctgtg actgaggaag agctgaaagc 1073161 tgacctcctg cgaatttgcg gaactgactt cggtttaacc gacccttcgt ggatgtcgcg 1073221 gtttgggaac gccgcgcgcc aagcgaaacg gtatcgggac ggcagaatct ttcttgcggg 1073281 tgatgccgcg catattcatt ttccggcggg cgggcaagga ctgaatgtcg gccttcagga 1073341 tgcaatgaac ctcgggtgga aactggcggc ggccatcaaa ggctctgcgc cttcttggct 1073401 tttggacagc taccatgatg agcggcatcc ggcagcggaa gggctcctca gaaacacgga 1073461 ggcacagaca aagctgatcg atttcactca agcaggcctc catttgcgaa gcatgatgtc 1073521 ggagctgctg gccttccctg atgtgaatcg atatgtagcg gggcaaattt ctgcgctcga 1073581 tgtcagatat gaagctgatc gtaccatgcc gccgaatcgt ttgaacgggg caaggctccc 1073641 tgacatgaag ctgattcttt ccgacggcaa ttcggaacgg ctgtacagct ttctccaaaa 1073701 cgggacattc gttttgctgt cattgaggca ggaagctgat gatcatatcg aagtaaaagg 1073761 cttacgtacg gtaaccgcct cgcttgcaga accgaatgaa aagttgcgga atgtgcatac 1073821 catattgatt cgtcccgatg gacatgtagc ctgggcggtg gatgcatcag cgcccgattg 1073881 ttccgaggtg attcaaaaag ggatcagccg ctggttttcc gtcaccagcc gagtataatt 1073941 caattcgatt gtttcatctg taacaaaacg gtatgataga agaaacaatc gaatgaaaaa 1074001 ggatggaaaa cccgatgaac acagatcata cgaaacgcaa tctttttgaa ttgtatgcgg 1074061 agctcattca tcagcaggag aaatgggagg ggcttattaa agccttttta tctgacgaat 1074121 tgaggaagct ggatgtagag cacgggagta aatctcaatt gacgatgaca gaaattcatg 1074181 ttctatcctg tgtcggggac aatgaaccaa ttaatgtcac gtcgatagca gaaaaaatga 1074241 atacgacaaa agcgactgta tcacgcatca gcacaaaatt gctcggcgca ggcttccttc 1074301 acagaacaca gctcagcgat aataaaaagg aggtctactt ccgattgacg cctgctggaa 1074361 aaaagctgca cagtttgcac aaatattatc atcagaaggc tgaacagcgt tttctgtcat 1074421 tttttgaccg ctataccgag gaagagattc tttttgcgga acggctgttt cgggatctgg 1074481 tgacaaaatg gtatccgtcg tcagaagaaa ttgaaggggg gcttcctagc atttttaaat 1074541 aaaaaacacg cactgcggtg cgtgtttttc gctttgtttc tatctttttc aaggctgtaa 1074601 cgtaaatcag atttcctctt gaagaatgaa attcaagatg ttcaggaatt tgcactgctt 1074661 atacgatatg tctattagta tctttatttt atacgttttc tactgtgttt ttgatgcttt 1074721 gttttcaagt gaaatagggt cttctgtttt agttctccta atctttacag aaatacctac 1074781 tagaatgacc gccatagttg taaatattcc catggttaat aagatcgtat cctggtttaa 1074841 actccatcca attaagaaag agatgatcgc tcctccgaaa cttgccgagg caataaataa 1074901 acttgtaact tcgtcaacgt acttctgaat aatgattgat gctagtgtta aagcaatggg 1074961 aaatatcccc gctatactta ggccaatcaa aaatgtacca ctcaattgaa gtattgggtt 1075021 acttatataa gagaaggcaa tcaacaaaac aattaaacaa ctacagctaa aaagaaggta 1075081 tttggaaaaa tcaagccttc tacttacgaa accaatcaat attcttccta tgatgatccc 1075141 tacccagaaa aaggagacac ttataagact aatttgttca ttgtcttggt ttatcatgat 1075201 tgaaggtaaa aagttggcaa aatttgtttc aattccagca tataggaaag cgaaaaatac 1075261 aaaaaagcct aattgctttg atttttttct atctcctata aagtattgaa atgctcctcc 1075321 atctggaaag gtcacttgtt ggttagcatt cttagcgtac tctcggttct tagacaagaa 1075381 aattaaccac cctacgaata ggacgaataa aaaggtgaat atacagtaat atggtaaaaa 1075441 ccagttattg atatctatga aggaattaat taataatggg aaagataaag cgcctaatcc 1075501 aaagagaact tccagcttac tcattttttc tgcattactt tcgaaattag caataacaaa 1075561 tgaaccaact gtcgtttcta atgtgcctgc tccatatcct aagagaaaag ccattacaat 1075621 aatataatac caatccttgg ttagaaaaaa gatacttaac gctacaagca ttattgtcaa 1075681 agctaaagta agtgtcctaa aatgactgta tttcttaatc attaaaggtg cgattaatac 1075741 tccgcttaga aatccggtaa actggaagaa gattatgacc gaaatatcat ctgttgtctt 1075801 gttaaaagcc tctaataaaa atggtgtcaa actccctgtt gatatatgga taatacctac 1075861 tgtaaaaaag aaagcatatc caaataaata tgtccctctt aacattcatt acacccctat 1075921 atgaaaaagc aggaaagtaa attcctgctt ttttagtaac ttctctcttt gaaatactag 1075981 ttgactgctg aaacagacat gggttgagag ttgctgtctt tctcaaagaa catttctaat 1076041 acttcctgag atctaaaacc atcactaaaa gaagggatct caacccaatc attctgagtt 1076101 gatgcaatcc aattgattaa ctcgcttcta aaagaatcag cccatccata aaactcgttt 1076161 ggcggatcgt ttaataggct ttgcggtact gggcagtcta ccacgttcaa gccatctatg 1076221 agcttgtaaa cgtgaggatt acctgtgtgg tatttaaact cttttttgtg tccaactacc 1076281 tcaatgctaa aaccacagtc ttcaggtaca gaacactttg atgtgatgat atttacaaat 1076341 accttgttct tcagctggcc ataaatttct gcatagtcat ctacaagtac ctgtttatcc 1076401 tcttttgttt ttacatttgt gttcatcttt gcccttactg attctgtgat gaaatcactc 1076461 tcgaacaaat accataccat gtcaataagg tgaataccca gatcccccaa tgatccactc 1076521 gtcttcttac tattagcgtc atctctccaa gtaaacttct tacgtctaag tgcactattt 1076581 ttcttgaagt gtacttttat ggacagtatg ttacctagtt cattattgat aattaagctt 1076641 tttaagatat ttacgtaaga taaatatcta taattaaatc ccatactggc tcttacgctc 1076701 aacctttcag cagtatcttt cattatgctt gcttcttcaa gagaaatagc cataggcttt 1076761 tcacataata catgcttatg ttttcctaat gcttgcaaag catgttcttt atggcaaaag 1076821 tttggtgatg ctacaattaa accttctgag gcatcaatta gttcatctac gttttcaaat 1076881 gacttcccgc cgaaagtttt cacaaagctt tccgcatttt gttgatttat gtcatatacc 1076941 cctactaact ctgcattttt tattgtagat aaagcagttg catgcgctct tgcaatacca 1077001 cctgcaccta tgatgcctat cttcttcatt tttatttcct cctcatgatc caattaattt 1077061 ttttaaggta ttagtaattc cttttgagta ctcactatca gttataaggt tgtgcaagtt 1077121 tttggcttcc tgtgttgcat tttttagcag atatccattc cctactgtct gtaacatacg 1077181 aacatcattt ccactatccc caaatgcgat agctctttcg gtatttaggt tgtatttctc 1077241 taacataaac gttacaattt cattctttcc tgtccctatg gggataaaat ctacatcata 1077301 gctgtcttct ggatcgcctg ctaagggatt acaccgattt atatttactg aaacgccgta 1077361 ttcttcgcag attttttcaa tagctaatag gtttttcttg tcgtttattt catcttgttc 1077421 ctgatagtag aagttatgct tataccgtga ctttcctaat tgggtttgag gattcaaaag 1077481 aatgttatga ttttcatgca gctgtttcac aagtttttca accttttctt tactaaaccc 1077541 ttcatttatg cgactgttcc acttgttatc ttgctgaccg aagttatgct ctgaaaagta 1077601 cgtaatttca gttccaagat cactagctat aaaatgcgga aaatatctaa attttcctcg 1077661 tcccatttta tcgagaatag attctatact gctcccagta acccatccga ttattagctc 1077721 cccatcttta cttttttgtt ctagatagtc ttcgagttca tagatgtctt gttgcttttg 1077781 ttcgtcgatt gtatgcggaa aatacgtttc atcaaaatca caaaaaacaa tatattgagg 1077841 atgttcaacc gtggataacg ttttatactc cgatttcttg cttaataaca tgaaacagtc 1077901 cctccattac tctgtcttgt tcttctaaag taaatgacgg atataaaggc aaatgcagta 1077961 cctgactatg agccttttcc gtatgaacca attggagtcc tgcatacttg tcctgtacta 1078021 aaggagtttt ttgcatatga gaaagtattg gataatatac atctgtttga acaccaaaat 1078081 cttcatttaa tttagtcatg atatctgccc tatcttctgt tcttacctta ataggaaaca 1078141 gatgccatac atgatcttca cttaattctg gtaattcaat atagccttta ttctgcaact 1078201 ctgctaattg ggtaatgtat ctatccgcca agaacaatct tttgaagttg tttaatgaaa 1078261 ggtacttcat tctctctaaa ccaattgctg cctgtaaatt gtccattttt gaattaaatc 1078321 caaaattgat gactttctta ttttttacat ttacttcaaa accgtgataa ctaaattgaa 1078381 tgcatttttt agcgagttct tcattatcag ttgctattgc cccagccttg ccacatacac 1078441 caaaattctt atagggatta aaacttaatg tagtgatgtc tgcatacttt cctaagtctg 1078501 tcagtccaat tccttggcag gcatcttcaa ttacttttaa tttataacga tttgcgattt 1078561 gacggatatg ctgcatgtct gaatgttttc cgtataaatg cacaggtaga ataaactttg 1078621 tataaggagt tattgcttct tcaattttgt caggatcgat gcagaatgtt tgtgggttaa 1078681 tatctacata gataggaacg cctcccgaag ctaacacagc attttcagta gctgaaaagc 1078741 tattagccgg catgataact tcatcccctg ggtttaaccc taaagccaat aaacctatca 1078801 taatagcatc ggttccactg ctggttgcaa ttacatacct tttatgtaaa tatgtagata 1078861 aaactttttc gaattgctct aaatagggac cactcgtaaa ttttccagtt ggcaaaactt 1078921 cagttaatgt atttaagata tcttccactt catcattggt tattaatctg tctacaggca 1078981 aaaaagggac tttactgatt tcacgatttt tttgatagtt gaaaaggtca tgttcaatat 1079041 ctatcttttc ttttaatact tgtttccacc gctcgtttac aatactgtct tcaataacaa 1079101 gttcttttcc ttgtacgtca ccttttaagt gttttaatag tgacatgttt tctttgcttt 1079161 tacctgaaat cttaacctgt ttttgcatga acagtacctc caatgatttt ataatctaaa 1079221 aatttattac aaatttatcc tagtttctga aatcggtaac atgtcaacaa cttttttaag 1079281 gaagggaaaa tatgcctaca attgatgaaa tagcaaaatt atgcaatgtg tctaaaacca 1079341 cagtgtcaag agtattgaat aatcatcctt atgtgtcgaa agaaaaaaga gatatgatct 1079401 taaaggctat taacgaactt gactacactc ccaattattt agctcggaat tttaggagaa 1079461 ataagacaca aacgatagct ttatcggttc cgagtatcga ccatccattt tttgctcaat 1079521 taataaaagg ggtctctcat gaagtactgt ttaagaatta caaggtaatt gtatttcaga 1079581 ccttttatga caaacagacg gagctagaat tactagagtt attgaagcat aaagaagtgg 1079641 atggcattat tcttgggact ttagaaaatg aatgggatca gatatcccct ttcttaaagt 1079701 atggtcctat cttattatgt aatgaatatc atcactcagc ggacatcacg ataattgggt 1079761 atgatgaatt tgaagccgca tacatggggg tagtacattt aattgaaaga gggcataaaa 1079821 aaattgggtt ttgttttgat actccatata gcgaagctca atgtcagagg aaagagggtt 1079881 atttgaaagc tttacaagat tacaatttac atcatagaag cgaatggata ttcggcgaaa 1079941 tgtttaatat cgaggatggc tttcgtgttt ttcataagat aaaggatcta aaggacagac 1080001 cctcagcaat atttacagga aatgatcaag tcgccgcagg gattattaaa caggcgatga 1080061 aaaatggctt taaagttcca gaagacttag ctgtaattgg ttttgacaac caattgattt 1080121 gccaagtcgt tactccgacc ataacaacaa ttgatatccc cgtaatagaa ttaggccaac 1080181 aggctgtgtt gaaaatcatc gagtccattt cgggtaatgc ctctttaaac agaagaatta 1080241 ttaaactgcc aacaaagctt attataagag aatcaacgta acgatagatt tccctttaac 1080301 attttatatc tttatataag aaaaagaggt tattcatttt aacctctttt tcaatcgtaa 1080361 gtcgtcaatt atttctttca tttcaccctc tggcagcact cacttcaaat ctgatccatt 1080421 aacaacgaaa tatccgctta tatttcctca tctcgatggt ttgcgaatta aaagttcttg 1080481 aacccttttt tcaactaggc actactgccg ctgattgagc tctttttgtc ttttttttca 1080541 ccatgaagat ggtgaagcag gcgataaaac ggcggcagca gggcaataac cagaatgacg 1080601 cgaatgacct gaaccgcaac gacaaaggtg gaatcagcat gtaaggtaac tgacgtcgtc 1080661 gccatctctg caatcccgcc gggcgcaaat gccagaacag aagtgatgag cgaaattcct 1080721 gtcagctcgg aaacgatcac ggcgctcaaa aacattgctg cgattaaacc gacggacgag 1080781 acaaacccga cgatgataat acgggtgacg ccggcaaaca tgcttttgta catcttagag 1080841 ccgatcgttg ccccgagaaa tacttgtgat acatggttag cttgtgacaa ccaccatgcc 1080901 gtcatgtcgt gccctgtcac cgcagctccg ccaacatgta caattgctac accgagcatg 1080961 ctgccgagca gccatggagc tggaaatttt aaaaatttcg cagctttgca agctccccag 1081021 gcagcgagaa taagaatgac ggtccacaaa acgggagcga gcctaaaatc tgtcgttgca 1081081 gaagaaatcg tctctgctgc ggcacttgcg gtacgatctt gttttgtata gatcagaatg 1081141 actaaaaacg gaatggaaag caccacgagc agcacacgca tcatttgaac gaggctgact 1081201 atagcggtat tggcgcctac ttcctgtgcg atgctcggca tggcggaaag tccgccggga 1081261 gcggtgccga caaagctagt catcatatcc gttttgctga aacgccaaag cacatatcct 1081321 gacagcatgg ccagcaggat agacaatatc agcataacgc cgactgaaaa ccaatggtct 1081381 ttgagaacag agagaacgga taaattcagc ttttggccca attcgatgcc gaggatcatc 1081441 tgcccgaggg cgagccatcg tcggttaatt cctttttggt ctggtgccat catcagccat 1081501 gccggccgta tcatggcgag gcagcaggcg acaatcagtg ttccgatcat ccatccaatt 1081561 gatattccgg ttaatgaaag aataaacccc ccggctgcac tgattgcgat aaaccataga 1081621 tctttgagga gattttcgtc tttcttcaat gtaaaaccct tcttcctttt tcacgtaaca 1081681 ctccaattgt tcacgtagtg aatgtattta ttactatagt atatttttgt tgataaagaa 1081741 attatgaatt attttctata agcgattcac ttttcttatg accttgtgtt cgagcttttc 1081801 tattgtgtaa gtcagagata aacccgctgt cagcagacac acggcaagag cgtaaaaaat 1081861 cacttctccg ccaaatgatg tcaggatcag cccgcctgcc agcggtccga ttgagcggga 1081921 tatatcccaa tgcagaccat agacagcata aaaccggccc agcaaatgag gcggcgccaa 1081981 tttcgatatg aaggtctgga tgtgggttag cccgatgctt tcaccaaccg tcatcaccgc 1082041 tgccgtcact aaaagcattg tcagagaggt tgagcatgca aagccggctg ccgcaaggga 1082101 gtagcaaata taagtaatga agaggatcgt tttcattgaa agcttttcgg tccctttgac 1082161 aagaggtact tggagaacac agctgaataa agcttttgct gctgaataga tggtcagcat 1082221 ggacagataa tcagaaaaca tgtttttgct gaacagcctg tatgttgttt ctgtttgtgc 1082281 atataacatg ctgatgggga gagaaagcag caaaagaagc aggacaggcc tgtatattgt 1082341 aaagctcgcg gacattttcg gggtaacagc tgggtgtagc ggctttgtct caggcagttt 1082401 cagtgcagcg atcagaaagt agataaacaa tgctgcagca tctaatgcga atatccacac 1082461 ggggttatga ttgtacagca gcatccccac tagcggtcct gccgtcagac ccgtcgaata 1082521 gatcgcattg atgaccgcaa acacttccga acgtctgctt tccggcgtgc tttcagcgat 1082581 ttgggcgcgg gaagcgggaa tgtacaacga tcttccgatg ccattcatga catagagaat 1082641 agcgaaaaca tacgcatgct cagcaaatac aaaccctgtc attgccgctg attgaagaag 1082701 caatgcggtc aaaatcgctg tgcgccgccc aagccgatcc gtcacccgtc ctgcagcgag 1082761 cgtcaggaaa atatcagcaa atggctgaag gctgatgatc agcattggca tcatgatact 1082821 gccgtttaat tgttcatgca gatacagcac cataaaaggt cccatcattg cacctgtcag 1082881 gcttgtcagc aattcgccga aaaagcggag ccgaacggga gcggtatatc tcgattttat 1082941 agagtgaaaa ctggtcaaca tgtgatcgcc gcctttcgct gtttgatata gtagtagtgt 1083001 atagaagggg cggcggccca aaaagtgaag aaaagaagag ataaaagttc cccttttgtc 1083061 gggaggtgcg gggattgaag ctgatagagc actacgtggc gcttgtaaaa acaggctgcg 1083121 ccgagtatgg gcaaatgaac gaaatgacgc tcactgagat tgccgactgt ttattttgta 1083181 cagaaagaaa tgcaaagctc attttacata agctggagaa cagcaattgg attatccggg 1083241 aaagcggggc ggggcgcggc cgcaaatcta aaatcgcgtt tcttcggagg cctgaggaac 1083301 tgcttcttca aactgcaaag gaatatacca tgtcaggaaa gcttaaaaag gcaaaggagc 1083361 tgcttcagca gtatcagtcc gcgtttccag ggcttcaaaa cgaatataac atgtggctat 1083421 cagaggtatt cggatttgtg acggagacag gcgagaatgg ggcgaaggat gtcctgcggc 1083481 tgttcatcac gcctgaatct gtcagcagtt tggatccatg ccaaatattt ttgcggtctg 1083541 agggccattt cgtcaaacag atatttgata cactcttcac gtttgattcg gatatgcagg 1083601 agccgaagcc tcatttggtt catggatggg aagaggtcgg aaaaaaacaa tggagatttt 1083661 ttcttcgaaa aggtgtgtta tttcataatg gacagccgct gacatcgcgg gacgttgcgt 1083721 ttacatttca gcgctttttg gaactggctg acaacccgta taaatggctt ctgcacggag 1083781 tgaaacaagt cttagaaaag ggcccttatt gtgtggagct catactcgat aagccgaatg 1083841 cgcttttgcc gtatgctctt tgtgatgaac ggctgtccat actgccggca gaacagggcg 1083901 gcgggaaaaa tggaacaggg ccttttcaga tgaatcagca acatagcggg atgcttgtgc 1083961 ttgaagccaa tgagcgctac ttcaagggac gcccctattt ggatcgcgtt gagtttgtgt 1084021 tttctgagca agccggagag atgaacggtt ttaccattca agaaaaacaa acatgtcctg 1084081 agcagcaaac tgtctttgat gagcggcatg ttcagtattt gtcgcttaat ctgaaaaaga 1084141 aggggcctct tcagcaccga agctttagaa aagcgctccg gctgctgatt tcctctgaac 1084201 ggctcgttcg tgaagcggga gggcaccgaa gaattccggt tacgtccttt ttgcatccga 1084261 gtccttttga gtgggagggc gtttcgccat ctgaattgtt gaaaaaaagc ggatacgagg 1084321 gcgaaacaat cgtgctttat accttttcgg aaacggatca tcgtgaggac gccgaatgga 1084381 ttcaaaatat ttgcgcccag cacggtatca ggcttacact tcaattctgt gatgctgctg 1084441 atctgcgacg gccggaaatc gtgcagatgg cggatatcat tcatgacagt gcgacgtttt 1084501 atcaagacag cgagtttggt tttctgcatt tgctgctgtc ggagaacagt ttcttgtatc 1084561 agcatctatc tgaaaagctg acacagattt gctcaggaat gacagagcgg atgttttcca 1084621 tgcctgaccg ctgttcgaga atcaacatcc tgcgtgacat tgaccggcag atgatacagg 1084681 agctgaacgc gatcccgctg tatcaaaatg tgctccaggt gacatcaagt aaaaatgtaa 1084741 aaggcctggt gcttgatgaa gagggatgga ttgatttgta ctccgtatgg ctgtccaaat 1084801 aaaaagaggg ttcttttttg aaccctcttt tttacgctgc catgctgcgg cattgttcag 1084861 cacaggtgaa gcaggctttc gcacatgctt ggcaatgatc atgatcgtgc tttccgcatt 1084921 cagtgccgca tgcttcacaa atatcggcgc aaagtgcaca aatttctttc ataaacgggc 1084981 tgtccgtttg catggctttg accgccagcg cgcaaatatc cgcgcattcc ctgtcaagcc 1085041 ggatgcatcc gctgagatga tgctgcacgc tttcttccaa gcatttagtg aaacaatgat 1085101 tgcaagcctt catgcaatcg atgcaagcct caatacaagc ctcagaatat tgctccatgg 1085161 ttgattcccc ctgtatgaca gtatatggtt ttatgtttca cggctgcatt tgaaaaaaac 1085221 aggggagtgt gtttttagct aaggggatat gtacatatac cctgaatggg tatatctaac 1085281 gttccatcag atagtatagg aaccagacag cgtgattttg ttcatcacgt gctgcgcgcg 1085341 taaagacgcc tttcgctttt aagtttgacg tttcctcggc cgcacgcaag taaaagtcga 1085401 cggtttcttg ttcatcttta aaagcggcgt ccagtcctct tgtgaaattg tccgggcatt 1085461 cttccgtttg tttcggcatg atgtgtttgc cggtaattga accatacagt gtggaaaatt 1085521 cacggaggtg gcgaatctcg tcacgcctga tttcttcaat ctgttttctg acctcatcgc 1085581 tgtgggcgag ttcggcaagc ttgcggtagc attgaatagc actgaattct ccgttgatgg 1085641 ccttctgcaa attccgaatc aaaacaggat cttcccggta tggcaccgga tagggatagt 1085701 agctgtaatg caaggggatt caactccatt cttaggaatt gggcttctgt aaaagtatat 1085761 gttgggcagg gagagatgtg cggagataat cagcttttta tatgtgaaaa ggccgttttt 1085821 accaatagat cagattggtc attttcgtca acattcgata aaatatagag agataaaaag 1085881 agaggggtct tctaatttgg gagcagagtt tttagtaggc aggtccggga gtggaaaaac 1085941 gaagctgatc atcaacagca ttcaggatga attgcgccgg gctccattcg ggaagccgat 1086001 catttttcta gtcccggatc aaatgacgtt tttaatggaa tacgagcttg ctaaaacgcc 1086061 agatatgggc gggatgatac gcgctcaagt gttcagtttt tcacgattgg cctggcgcgt 1086121 cctccagcat acgggaggaa tgagcaggcc gtttctgacg agcaccggcg tacaaatgct 1086181 cctgcggaag ctcattgagg agcataaaca ggagttcaaa gtctatcaaa aagcgagtga 1086241 caaaagcggg tttaccgcac aggttgagcg gatgctgaca gagtttaagc gctattgtct 1086301 ggaaccggag gatatccgcc ggatggcgga aagcggaacg gcttccgagt atcgcggaga 1086361 acgtgtttta tctgaaaagc tccatgactt atcaattctg tatcagcaaa tggaaaaaag 1086421 cctcgcagat caatatcttc actctgagga ttatttgaca ttgctggcag agcatatccc 1086481 gcttgcggaa gatataaaag gcgcccatat ctatgtggat ggcttttatc agtttacccc 1086541 gcaggaattc agggtgttgg agcagcttat ggttcatgcg gagcatatca cgttttcgct 1086601 cacagcggac aagccgtcat atgagcggga gccgcatgaa ctggaattgt tcagaatgac 1086661 ggggaaaacc tattaccgcc tgcatcagaa ggcgaaggaa ctgaatttgg acattacgta 1086721 taaagagctg agcgggactg agcggcatac aaagacgccg gaattggcgc atctagaggc 1086781 acagtatgaa gcgcgtccgg ccattccata cgcagaaaaa caagaagccc ttactgtgat 1086841 gcaggccgca aacagacgag ctgagctgga aggcattgct cgggaaattc acgccctagt 1086901 cagagagaag ggatatcgct ataaggatgt agcaattctt gcgcgccagc cggaagacta 1086961 caaggatatg gtgaaggaag ttttcgcaga ttacgagatt ccttatttca ttgacggaaa 1087021 agcatctatg ctgaaccatc cgttaattga atttatccgg tcgagccttg atgttctgaa 1087081 agggaattgg cgttatgaag cggtgtttcg ctgcgtgaaa accgaactgc tattcccgct 1087141 caatgaaccg aaggccaaag tgagagaaca ggtcgatcag ctcgaaaatt actgtatcgc 1087201 ctatggtatt aaaggcgacc gctggacaaa gggcgatcgg ttccaataca ggcgttttgt 1087261 gtcattggat gatgattttg cgcagactga tcaggaaatc gaaatggaaa acatgttgaa 1087321 tgacacccgc gattggattg ttccgccgct ttttcagctt caaaaacgca tgaaaaaagc 1087381 gaagacggtt caagagaagg cggaggcgct ctatcgttat ttagaagaga cggatgtgcc 1087441 gctgaagctg gatcaggaaa ggcagcgtgc tgaggatgac ggcagaatca ttgaagcgca 1087501 gcagcatcag caggcgtggg acgcagtcat tcagctgctt gaggagtttg ttgaaatgat 1087561 gggagatgat gagatttctc ttgatttgtt tcagcaaatg atagaagccg gcgcggagtc 1087621 gcttacattt tctctaattc cgcctgcgct tgaccaggtg tttgtcggca atatggattt 1087681 gtccagaatg tatggcacct cctgcacctt tgtgctcggg gcaaacgacg gcgttctgcc 1087741 ggcacgccct gatgaaaacg gggtcctgtc ggatgatgac cgggaatggc tgaaaacgat 1087801 tggggttgag ctatcctcag gcggacgaga gcgtttgctt gatgagcact tcctcatcta 1087861 catggcgttt tcaagtccgt ctgaccggct ttacgtatcg tatccgattg ctgatgcgga 1087921 aggaaaaacg cttttgccgt cgatgatcgt taagcggctg gaagaactgt ttccgcatca 1087981 taaggagcgc ctgttaacaa atgaacctga acaggtcagc gatgaggaac agctgatgta 1088041 tgttgtgaat aaaagcgtgg cacagtcctt taccgcgagc cagctcaggt tatggactcg 1088101 ggaatacgac atcagcgacg tctggtggag cacgtacaat gtgctgatga gtgagcagga 1088161 caggctgcaa tcgaaaaagc tgttctcaag cctgtttttc cggaatgaag tgaagcagct 1088221 tgaacgcagc gtgtcgagac agctctatgg tgaacgtatt cagggcagtg tatcgagaat 1088281 ggaaaccttt aacgcatgcc cgttttccca ttttgcgtca cacgggctgc atttgaagga 1088341 acggcaattc ttcaagcttg aagcaccgga tatcggccag ctgtttcatt ccagcttaaa 1088401 gctgatttcg gacaggctgc gtgagcaaaa gctggattgg cgcgatttaa cgaaggagca 1088461 gtgcgagctg ttttcctatg atgcggtaga gcggctggca ccgaaactgc aaaaggaaat 1088521 tctgctcagc tcaaaccggc attattatgt gaaggaaaaa ctgcaaaaaa ttgtgacacg 1088581 tgtgtccggc attttaagcg agcatgcgaa agcgagcgga ttcgtaccga tcgggcttga 1088641 actgggcttt ggaggaaaag ggccgcttcc gccgctgacc tttcaactga aaaacggctg 1088701 tacgatggaa ctcgtcgggc gaattgaccg tgttgataag gctgaaagct caaaaggcct 1088761 gctcctcagg attgtcgatt ataaatcaag cgacaaaggc cttgacttag cggaagtata 1088821 ttacggattg gcactgcaaa tgctgacgta ccttgattta tcgattacac attcagctga 1088881 ctggctcggg atgagggcga cgcctgccgg agtgctgtat ttccatattc atgacccgat 1088941 gattcaatct aatctcccgc ttgggcttga cgagattgaa caggagatct ttaagaaatt 1089001 taaaatgaag ggcttgctcc tcggtgatca ggaagtggtt cgcctcatgg atacaaccct 1089061 tcaagaggga cgttcaaata tcataaacgc cggcttgaaa aaagacggct ctctcagatc 1089121 agactcagca gcagtcggtg aaaaggaatt tgatcttttg acaaagcatg tgcgccgcac 1089181 cttccaagaa gcgggcgaac aaatcaccga cgggcgcgta tccattgagc cgtacaaaat 1089241 gaagaacaag acgccgtgca catactgtgc gttcaaatca gtatgccaat ttgatgaatc 1089301 actggaagaa aacgagtatc gcccattaaa ggctgaaaag gacaagacaa tacttgagtg 1089361 gataaaaaag gaggcggatg gcaatgaaca ttcctaaacc ggcagacagc acatggacag 1089421 atgaccaatg gaatgccatt gtttcaaccg gccaggatat tcttgtggca gcggctgcgg 1089481 gctctggtaa aaccgctgtg ctcgttgaac gaatgattcg gaaaatcacc gcggaggaaa 1089541 acccaataga tgtagaccgt cttctcgttg tgacatttac aaacgcctca gcggcagaga 1089601 tgaagcaccg aatcgcagaa gccttggaaa aagagcttgt acagcgcccc ggctcgctgc 1089661 atattagacg ccagctgtct cttttaaacc gggccagcat ttcgacgctc cattcctttt 1089721 gcctgcaagt gctgaagaaa tattactact tgatcgatct tgatccgggc tttcggatag 1089781 ctgatcagac ggaaggcgag ctgatcgggg atgaagtgct tgacgagctg tttgaagacg 1089841 aatacgcaaa gggcgaaaag gcgttttttg agcttgttga ccgctatacg acagaccggc 1089901 atgatctgga tctgcaattt ctcgttaaac aggtgtacga gtattcccga tcccatccca 1089961 acccggaggc gtggctggaa agctttgttc atttgtatga tgtatcagaa aagagcgcca 1090021 tcgaggagct gccgttttat caatatgtca aagaagatat tgcaatggtg cttaacgggg 1090081 cgaaggaaaa gctcttgcgc gcgcttgagc tgacgaaagc gccgggcggc ccggcgccgc 1090141 gtgctgacaa ttttcttgat gatcttgctc agattgatga actgattcag catcaggacg 1090201 atttcagtga actatataag cgggtgcccg ccgtctcttt taagcgtgcc aaagcagtaa 1090261 aaggggatga gttcgatcca gcgctccttg atgaggcgac agatttgagg aacggcgcaa 1090321 aaaaactgct tgaaaagctc aaaaccgact acttcacgcg aagtcctgaa cagcacttga 1090381 aaagcctagc cgagatgaag cctgtcattg aaacgctcgt acagcttgtc atcagctatg 1090441 gaaaacgatt cgaagctgcg aaacaggaaa aatcaatcat cgatttttcg gatttggagc 1090501 attactgttt agcgattttg acagctgaga atgacaaagg tgaacgtgag ccgagcgagg 1090561 ctgcaaggtt ttatcaggaa cagtttcatg aggtgctcgt tgacgaatat caggatacca 1090621 acctcgtgca ggaatcgatt ctgcagctcg tcacaagcgg tccggaggag actggtaacc 1090681 tgtttatggt aggagatgtc aaacagtcga tttatcgatt caggcttgcg gagccgcttc 1090741 ttttcctctc taaatacaaa cggtttacag agagcggaga aggcacgggg cggaaaatcg 1090801 atttaaataa aaatttccga agccgggctg atattttaga cagcacaaac tttttattta 1090861 aacagctgat gggcggcaaa atcggtgagg tcgattatga cgagcaggct gagctgaagc 1090921 ttggtgcagc gtatccggac aatgacgaga cggaaacaga gctgctgctg atcgacaacg 1090981 cagaagatac ggatgcaagc gaggaagcag aagagcttga aacggtgcag tttgaggcaa 1091041 aagccatcgc taaggaaatt cgtaagctga tttcatcgcc gtttaaggtg tatgacggaa 1091101 aaaagaaaac acatcgcaat attcaatacc gagatatcgt gattttgctc cgttcgatgc 1091161 cgtgggctcc gcaaatcatg gaggagctga gagcacaggg cataccggtt tacgccaatt 1091221 taacgtcagg ctattttgaa gcggtcgaag tcgccgtcgc gctttctgtg ctgaaggtga 1091281 ttgataatcc gtatcaggat ataccgcttg cctctgtgct gcgctcaccg attgtcggag 1091341 cagatgaaaa cgagctgtct ttgatccggc ttgaaaataa aaaagcgccg tactatgagg 1091401 cgatgaaaga ctacctggct gctggtgacc ggagcgatga gctttatcaa aagttaaata 1091461 cgttttacgg acatctgcaa aaatggcgcg cgttttcgaa aaaccactca gtatctgagc 1091521 tgatttggga agtgtaccgc gacaccaaat atatggatta tgtcggcggc atgccgggcg 1091581 gaaaacagcg ccaggccaat ttgcgtgttc tttatgacag ggcgcgtcaa tatgaatcaa 1091641 cggcatttcg cggcttgttc cgtttcctgc ggtttatcga acgcatgcag gagcggggcg 1091701 atgatcttgg tacggcgaga gcgctcagcg agcaggagga tgttgtccgc ttaatgacga 1091761 tccacagcag caaagggctc gaatttccag tcgtgtttgt agcaggtctc ggccggaatt 1091821 tcaacatgat ggatttgaac aaatcgtacc tgctggataa ggagctcgga tttggcacga 1091881 agtatattca tccgcaatta cgcatcagct atccgacact tccgctcatt gcgatgaaga 1091941 aaaaaatgcg cagggagctg ctgtcagagg aattgcgtgt gctctatgtt gcattaacga 1092001 gagcgaagga aaagctgttt ctgattggct catgtaagga tcatcagaaa cagcttgcaa 1092061 aatggcaggc atccgcgtcc caaactgatt ggcttctgcc ggaatttgac cgctatcagg 1092121 cgagaacgta tctagatttc attgggccgg ctcttgccag gcacagagac ttgggggatt 1092181 tggctggtgt gccagcacac gctgacatct caggtcaccc ggctcgtttt gccgttcaaa 1092241 tgatccattc ctatgatttg cttgatgatg atctggaaga aagaatggaa gaaaaaagcg 1092301 agcgcctaga agcgatccgc cgaggtgaac cagttcccgg ctcgtttgcg tttgatgaaa 1092361 aagcccgcga gcagctgagc tggacctacc cgcatcaaga agtgacgcaa attcggacaa 1092421 agcaatcagt ttctgagatc aagagaaaaa gagagtacga ggatgaatac agcggcaggg 1092481 cccctgtaaa accggctgat ggaagcattc tgtacagacg tcccgctttt atgatgaaaa 1092541 aaggcctgac agcggcagag aaagggactg ccatgcatac ggttatgcag catatcccgc 1092601 tgtcacatgt gccgtcgata gaagaagctg agcagacggt tcacaggctt tatgaaaaag 1092661 agcttctcac tgaagaacaa aaagacgcta ttgatataga agaaatcgtg caatttttcc 1092721 atacagaaat cggcggacag ctgatcggtg ctaagtggaa ggaccgggaa ataccattca 1092781 gcttagcgct tccggccaag gagatctatc ctgatgcaca cgaggcagat gagccgcttt 1092841 tagtgcaggg tattattgac tgtctctatg aaactgagga cggattatat ctattggatt 1092901 ataagtcgga ccggattgag ggcaaattcc agcatggatt tgaaggagcg gccccgatct 1092961 tgaagaaacg atatgaaacg caaattcagc tgtacacgaa ggcagtggag caaattgcaa 1093021 aaacaaaggt aaagggatgt gcgctttatt tctttgacgg agggcacatt ctgacattat 1093081 agcgagatcc ataagctccg gaatttcagg cggagcgggt ctcgttttct atataaaaga 1093141 gaggtgaaag catttgcgga ttttacatac ggctgactgg catcttggaa aaacgcttga 1093201 aggaagaagc aggctgagtg aacaggccga tgtgctggat gaactgaata cgattgtaaa 1093261 ggatgagcag atcgatgcca ttgtaatggc gggggatgca tttgacaccg taaacccgcc 1093321 agctttagcc gagcagctgt tttatgaaag cctgtctgcg cttagcgaca gaggaaagcg 1093381 cccgatcgtc gtcattgccg gaaatcacga taatcctgac cgtttgtccg ccgcttcacc 1093441 gctgacacat gaaaacggca ttcatttaat cggttatccg acaacagagc cgattcatat 1093501 tgaagtgcct tcagcaggag agcttttggc ggttggagcg ctggcgtacc catctgaagc 1093561 gcggttaaat gaagtgctat ccgatacgtt tgatgaaaag ctgctccgtg atcactatga 1093621 tgtgaaaatc aggcaggcgt ttgagcatat gacaagccgg ttccggaccg atgcagtgaa 1093681 gattgccgcc agccatattt atgtggcagg cggaaaccaa accgattcag agcggccgat 1093741 tgaagtcggc ggtgcataca cggtggctgc tgaaagcctg ccggcagatg ccgcttacgt 1093801 tgcgctcggc catttgcatc gcccgcaaac gatcaagcgg gcgcggacgc ttgcgcgtta 1093861 ttcaggatct ccgctcgcct acagcttttc tgaagcgggc tacgctaaat cagtgacgat 1093921 tgtggacgca aagcctgggg aagaggccac ttggcaagag gtgttattat caagcggcaa 1093981 gccacttgtg aagtggaaag cggcaaatgg attaagtgag gtgtacagct ggctggatga 1094041 aggcagagat cagaatgctt ggattgactt ggaaatccgt gtcgcggacc agctgtcact 1094101 tgaagagatt cacaggctgc ggaaggcgca cccgggcttt atccatatca ggccggtttt 1094161 tgaagaacag aacaaagacc gggaacggat cgaggttaaa catgtctcaa tcgaggaccg 1094221 ctttaagaaa ttttatgaaa aacaaactgg cggtgcggtg ccggatgaag aaatggtgaa 1094281 gctgttttta gagcttgcat caggcgttga agaggaggat gcgaaatgaa gccgatcgcc 1094341 ttaagcatta aggggctcca cagctttaga gaggagcaga cgatagattt tgaaggcctt 1094401 tccggtgccg gtgttttcgg cattttcggc ccgacaggaa gcggtaaatc ctctatactc 1094461 gacgcaatga cgcttgcttt atacggaaag gtggaacggg cggcgaataa tacgcacgga 1094521 atcttaaatc acgccgaaga tacgctgtct gtgtccttta cctttgcgct tcagacgaat 1094581 caccaaatct catacaaagt cgagcgtgtg tttaagagaa cggatgaaat gaaggtaaaa 1094641 acggcacttt gccgcttcat cgaaatcaag gacgagcata cggtgctggc tgataaagcc 1094701 agcgaagtga ataaaagagt ggaggagctc ttagggctga cgatcgacga ttttacgaga 1094761 gcggtggtgc tgccccaagg gaaatttgct gaatttctgt ctttaaaagg ggcagagcgc 1094821 aggcatatgc ttcagcgttt atttaatttg gagcaatatg gagacaggct tgtgaaaaag 1094881 ctgagacggc aggcgcagga agccaatgcg agaaaaaatg aaatgcttgc tgaacagtcc 1094941 ggtctcggtg aggcgagctc agaggcagtg gagcaggctg aaaaggttct cgaacaagct 1095001 gaagcccggc tggaagcgat gaggaagaac cgtgatcagg cgaaggagcg gtttacagag 1095061 catcaggaga tatggaatgt ccaaaaggaa aaatccactt atgaagaaga ggaaaaacgt 1095121 ctcgcagaag aacagccgca tatagacagc atgcaaaaac gcctgctgga agcagaaaca 1095181 gcagcagccc ttaagcccta tgcggaccgg tacgcagaag cgatccagca tgaggagcaa 1095241 gctgaaaagg aacaaacgct agcccaaaag gatttagcag accggacagc tttctttcag 1095301 caaaaacatg aagagtatga agcgtggcgc cagcataaaa gcgagaaaga gcctgagctt 1095361 ttagccaaac aggaacagct ttcacgcttg caggaaatcg aaatcaaact gagtgaggcc 1095421 aagcaagagg aagagcgcaa aaaggctgac ctccggcaga aagaagaggc tcttcaatct 1095481 gtcatgaatg aattagagac cgtaacagac cgcctgacac gagggcaaaa cagacagaca 1095541 gaattgaagc agcagctcaa atccctgcag gtgacatccg atgagcgaaa aagctgccag 1095601 caggccgcag agatggcatt gcgcatcaga caaaccgagg aacaaatcaa aaaagagaaa 1095661 aaacgaagtg aagaattgaa cctcgtgctg cagaagatga atgaagagaa gaatacactc 1095721 gttcaaaaga cggaagcgga agaaaacaac atcattcagg catatgaggc agttcaaact 1095781 gtgtaccatt tggtgtgcga aacggaacgc tcattaacac gtatgacgga agaggctaga 1095841 aagagtcaac acacgcttca cttacagcgt gaaaaagcaa gggtggcact gctgacaaaa 1095901 gagttagccc aaaagctgac tgccggaaag ccttgcccgg tatgcggttc aaccgatcat 1095961 gatccatctg cctcggtaca tgaaacgtat gaagccgaca gccatcttga agaggacatc 1096021 aaacggacag atgtgttatt gacggaagct gcagctctca gccaggagat tctttcagcc 1096081 aaaattatgc ttgaagaaca gtccgcgcgc tttattgaac agtgtccgtt tttgcagaca 1096141 attcaagcac agaaccttga agcggcagct tccttcgaac atcagccggt gtatgaagca 1096201 tttgaaactg ccaaatttga atggaaacga atcaagcagg acattctttc tgttaagaca 1096261 cgaatggcac aaatgattgg cgcctatcag gagtctttaa aaaaggccga gcagcttaat 1096321 gaaaaaatcg gttttgaaaa aagagaagcc gaccgtattg aaagcatcat cagtgagctt 1096381 caatcctcaa tggacagcag tctgaacatg tttaaagaag catttcagaa tcaatctgtg 1096441 gacgaagcag aaaaatggca gcaagccatt gaagaaaagg accgggctgc agaagaatgt 1096501 gaaaaacgaa ttgagaagag tatcgcgttt cttgctgagc atgaagcaca aaaggaaaaa 1096561 ctgcgggaat cgggacaccg gcttgagcgg gaaaagctgg agcttcatta tgcggctgaa 1096621 cgcatcaaga gcgtgatagc tgattatgag cacgaactcg gagattatgc aaaaggagat 1096681 tcgattcaaa tcaaactccg ctctgtccag caggatctaa agctgttaaa ggaaaaagaa 1096741 caatctttat atgaagaact gcaaagcgcc caaatgaagc tcaaccaagc gaaaagccgc 1096801 gcttctgcaa gcgagctcac tcttcaagag gcgaagggca gattggaaaa agcaaaagct 1096861 gcttggcttg agcatacaaa aaacacctcc attacccgga ctgaggaggt tgaacaaagt 1096921 ctcatcccag ctgatgaact tgaaaagatg aaaaccggca tagaccagtt tatggataaa 1096981 ctgaagcaaa atgctgcaaa cttaaaacga gtagcagaga tacttgccgg cagagcatta 1097041 tcagagagcg aatggaacga aaccgttgca gcattacaag aagctgagga cgcatttggc 1097101 gctgctatag aggaaaaagg cgcggccgca aaagcactgg ctgtcattcg cgaccatcat 1097161 aaacggttta atgaaattga agctgaactg aaaaaatggc agatgcatat cgacaggctg 1097221 gacaagctgc aagctgtgtt taaaggcaat accttcgtcg aatttttagc tgaggagcag 1097281 cttgaaagcg ttgcgaggga cgcctcagca agactcagta tgctgacaag acagcgctat 1097341 gccatcgaag tagattctga gggcggcttc gtgatgcggg atgacgcgaa tggaggcgta 1097401 cgacgcccgg tttccagttt gtctggagga gagaccttcc tcacctcgct ttcacttgct 1097461 cttgcgctgt ctgcgcagat tcagcttcgg ggggaatacc cgctgcagtt ctttttctta 1097521 gatgaaggct tcggcacact ggatcaagat ctgcttgata cggttgtaac ggccttggaa 1097581 aaacttcagt cagacaacct ggctgtcggt gtcatcagcc atgtgcagga actgcgtgca 1097641 cggcttccga aaaagctgat cgtccatccg gctgaaccga gcggccgcgg tacgcgggta 1097701 tcacttgagt tgatgtaagg gaggagcgga tatggcaaag cagattgccg gaatatgtga 1097761 gctgtgcggc cggagcgatg tccagctgac agagcatcat cttacaccga aagaggaagg 1097821 cggaacgttt ttgccgacag cgatgctctg tattccttgt cataaacaga ttcatgcctt 1097881 atataccaat caagagctcg ctgtacgttt aaatggaatg gctgaactca gaagcgatcc 1097941 agagcttgcc cggtttgtca aatggatcag aaaacagccg cctgagaagc tgatcaaaac 1098001 taagaaatca aatgaacgaa aaaagaaaaa atgactaaaa agcagccctc tctttgcaga 1098061 gcggctgctt ttatccgttt ccaaccatat cctgatcgtt gacatcgggg tctatataat 1098121 ttgtcgcgtt gactgcatta tttaatagaa ggaaatctcc cgtgtttcct gctcccgaac 1098181 cgagcgcaga ttttgaagag cttttcggag aaaggtaaaa ggaatcacca aagtttacga 1098241 ctccgcccga tatggaattg atagctatag gcccgacaat tgctggcata aacgacaccc 1098301 tttatcgaag tctctgttta ttatatgttc ttggcgggcg attgtgagcg cggagactga 1098361 atctgtctga tatgtttgag tctcgcatca ccgcgaataa gcgaagctga tccggcatgt 1098421 aaaacagaag aggctgagac cccttgaatt ttgatgctgc gaacataaat agccggcacc 1098481 tcgtggcaaa acgcgctttg tacacctgtt tcggggagcg gcttcacggc ctgctgctga 1098541 aagatctgat actccttttt gttaaatgag ccttcattat ggtaaaacgt ggacagagaa 1098601 cgctgcacag caaatacttt tacactcata tcgatttcat ttgtgtcgcc aacttgaaac 1098661 acacttgcga tcccgagaga attaaactta actagtctga tgcgcgatat gcgtttaagc 1098721 attattctgg cgcaagcgga gcaaacggcc caataataag agattcaggc ggtgtatcaa 1098781 aaatagaaga caggtagatg gattcagtgt ctccgatgtg gaaaacggag gaactggaca 1098841 caccgttcat ccgaatatcc ccgacttcca agctgcggtt gatgactgta aagatcatgc 1098901 ttgctcatct cctttcattt ctgatggaat atgctccaga aagtgttcta cagcgcggat 1098961 gacatcacgc ttcacatgct cagcgatatg ttctgcatat tgtgcaggcg gtgtattttc 1099021 ttcttttttg atatgggaca tataatagtg aatcctgctg tccatttgtt ttctgatgtc 1099081 ttcaataaca tgatgtctgt ttgtatcgtc aagtctgctg tcatattgat tttcaagctg 1099141 ttccaaaata tctgggattt cctcggttaa gtacatgtcg acattctggc ggatctgctg 1099201 catgagctga gcgctctctt cctgctgcat catcccgatt tgcggtgtcg actggctgac 1099261 gtcaaagttt tggacgctgt tcgggtcagt cggatttaaa ccgatattca aagtcccgtc 1099321 gagcctttcg attttcagct gatcaaattt atactccaca cgctcaatgg tagtggccgg 1099381 ccgctgtttc atcgtattca tttcagtttg aatctctttc agctgacgtt cgagctgctg 1099441 aatgtgaatc gcctgctgct gaacgaagga attcaagttt tgcaggtaag aggaaacaga 1099501 ttgatcatac atgttcttca cctctttcat atgattaacg gccaggaggc tggagcggga 1099561 ccaatgaacc tgtgtcgggc tcctgcagct ggagcggttg ccctgagcca gaaacttctg 1099621 gtgccggctc tacatagctt cctgtattat acaaatttga cagtgacttg attgatccgg 1099681 cgctcccgat ttgcagaatg gaggagttgc tgattgattc cagccggaga tagttgattt 1099741 gaatggtttg attaatatag aagttcatga gcctcactcc ttttacgcat tggccacgat 1099801 cggctgatca accgcatcat tgtcatacac attcgtcgcg ttttgataat tcatcacctt 1099861 gaggctgtcg ccggtattaa agctgccagc accggcaaac gttctgacct gagcctgagg 1099921 agaaatcgta atgcagtccc cgatgtgaac gactccgctc gtaccaatcg cattaatttt 1099981 aaacgctccg acaatggccg gcatacgagc acatcctttg ttgaaaaatt aaaaaaagac 1100041 aggtaaagtg aaatgacaat tccgatttca attgggctat tcacgatagc ttatgacaaa 1100101 cgcacatatg tgtgagagaa attttaaggg gacatatcgg ctctttgtga aagcgtttta 1100161 ttttttcggg ccgttatgtt taaacatggc aaaagaggat gttgggtata aattgagcgg 1100221 aaatgcggcg aaggatgccg ctatccgcct atggtgattt ttgtttattt ctttggtgtt 1100281 tttgcgtgta gaatgctttt tggagtatgt cgtgctgcgg tattcgattt ttgggcgggc 1100341 acattctcgc cctgaggtat atctcagaag tgctgagcaa aaatcggagt taaatgtggt 1100401 gtattctaat tgttatagaa aatgatttac atacgggagt tttcaagata tctcccaaaa 1100461 atcatttctt ctttaatccg ggtattcagc aggatatcca gctcttggct gcattgaatc 1100521 gtttcttttg aattcatgcc gtatttttgt gcggtttcaa ttagtgtgat cctcatttct 1100581 tcaattttac tgttcattac gctatctcca attctagatt ttattttgat ataaatacag 1100641 gatatcgtta gtataaccta ttttggctca aaaggttgcc tttcgtcaat ttgactaaaa 1100701 aagcgacaat ttttgctgcg gcctttttta atggagaaag gactaaagtc ttgctaagtg 1100761 tgcttgcaaa aagtcctgcc gttcctcaat ttctctaagt atgttggtct gctccttttc 1100821 gatttgaaag gggctttttt tgataaaagg atcatcagca gcactttgac aaatgtcaag 1100881 gtgccattcg ttgatgagag gagataatcg ttcaatagta aacgaccgct tcagcacgtt 1100941 tttcattaag gtgtgatatt gcgacctgaa ggcgggaatg gatagaagcc ttgacgaaag 1101001 cgtctttcct tttgtcagaa gcgggtcttc ttcataccat tcttgtacgg caagcgatct 1101061 tgtctccatc ggggaaacgt aaagccgacc ggattcgttt aaacaaaatg tgtagtaaaa 1101121 gccttgattg gtgcaggtgt tgccgatcag ccacaaaaaa aacagcttga catccagata 1101181 caatttaatc ctttcagcca attcgtcatc tccggctgtg cggatcagta tgaaaaattc 1101241 atgtaagaat gccgaggaat cattgttaaa aagggacaat ggaacccttg gatcggccgt 1101301 cttcactccg taactccttt taccggctgg ctgatggttc ttgatgttca aataaatgcc 1101361 ttcaggctgg ccattgatgg tcagaaagct gtacgaggca acgggagcag gtacgccgat 1101421 ctggtcaaaa aaacaatagg cgagtctgcg ccgcatcagg gacggatcat cctgttctgc 1101481 attcaaaaaa agtgtccttt caccaagcag agacttttcc cagctgattt cataggatgc 1101541 cttttccgct ctgtcacgct gtgtgagaag aatgggagaa acagatcgat ctgttacgaa 1101601 aagccccttg gctgtacctt tccttttcag ctgctcccga tgaaaaaata aatgcacgcg 1101661 ctccatattc tttcctcctt ctcaaaacga catttgtatg atatgtagag caagcccgtc 1101721 ctgaaacgaa atgaaaacgg aattgagaaa aagggatttc agcattcgac agagaataca 1101781 tgaaggagca ttctgattta aaagatgatg gaggaataac atgaaatttg cgacagggga 1101841 actttacaac cgaatgtttg tcggcctgat cattgacgat gagaaaatta tggatttgca 1101901 gaaggctgaa aaaaaactgt ttgaacttga gacgattccg ggatcgctga ttgaatgtat 1101961 cgcagaaggg gataaattcg ttgcgcatgc aaggcagctg gccgagtggg caaagaaacc 1102021 gaatgatgag ctgggatcat ttatgtattc attatctgag gtgaagctcc atgcacccat 1102081 tccgaagcca tcaaaaaata tcatctgcat cggcaaaaac taccgggatc acgcgattga 1102141 aatggggagc gaggctgata ttccggagca tccgatggta tttacaaaat cgccggtaac 1102201 ggttacgggg catggtgata tcgtaaagag ccatgaagag gttacctctc agcttgatta 1102261 tgagggagaa cttgctgtcg tgatcggaaa aagcgggact cgcatttcaa aagaagatgc 1102321 atatgaccat gttttcggat atacgattgt gaatgatatc acggcgcgtg atctgcaaaa 1102381 aaggcataag cagtttttta tcggaaaaag cttggatacg acatgtccga tggggcccgt 1102441 gcttgtacat aaatcatcta ttcaggagcc agagcgcctc aaggttgaaa caagagtcaa 1102501 cggcgagctg cgccaatccg gttcggcaag cgatatgatc ttttccattc cggaattaat 1102561 tgaaaccctc tcaaagggga tgacgcttga agcgggcgac attattgcca ccggtacgcc 1102621 gtctggtgtc ggcaaggggt ttacgcctcc aaaattcttg cggtcaggtg acaaaattga 1102681 tattacaatt gatccgatcg gaacgctgtc aaaccaaatt ggctgaataa aactggaggg 1102741 cggacccgga cccgcccgtt ttttctgata atcatctttg tgacagagga caagttcatg 1102801 gtactataag tggggtaatt tatctgatag ggggaacata tatgacacac ctacatatta 1102861 cgacatgggt ggtagcgctg attctgcttt tcgtcagcta ctcgctgtat tcgtcaggaa 1102921 gtgcaaaggg cgcaaaaatc actcatatga ttctgcggtt attctatatc cttattattt 1102981 tgacaggagc tgagctgttt gtccgtttcg ccaactggaa cggagaatac gccggcaaaa 1103041 tgattctggg cattatcacc atcggcctga tggaaatgct cctcatccgc aagaaaaaag 1103101 aaaaatcaac aggaggcctg tgggtcggct tcgtcattgt ccttttgctg acagtgctgc 1103161 tcggtctgca tttgccaatt ggttttcaat tgttttaata gaaaaaccta tgaacccggc 1103221 tctttgatag agctggtttt ttttatattt atcccctcat attccaaatc atttaaaata 1103281 accttaaaat tccctgtaag cggtatctcg tcctatgaaa ttatgatacc ttcaaggaga 1103341 ttcattattt tgcaggaggg ataacatgaa acgcagaaaa ttcagctcgg ttgtggcggc 1103401 agtgcttatt tttgcactga ttttcagcct tttttctccg ggaaccaaag ctgcagcggc 1103461 cggcgcgatc gatcaggcgg ctgctctgga aaacggcaaa gagcagacag gcgccatgaa 1103521 ggagccggaa caggtgaaat ggtacaaagt gaccccggga gcaacggata ttcagaaaaa 1103581 ctcacatatg gcactgaccg taaagagtga ttcagtactg aatgtatctg tatatccaag 1103641 taaggaaaaa gcgcttaaag atgagacgtt tgagatgtac cgttctttca cagcggagga 1103701 tggaaaaagc gaagtcattt ttccatacgc gtggagcggc ccttactatg taaaagttga 1103761 atacctcgga gaagaagaac cagaggacgg cggaacggca gaagcagctg cagaagccaa 1103821 gtatacgatt gggtataaag gcaccaaaaa acagccgtca gatttagaag aggaagaagc 1103881 ttgtccggtt gaaatgagtg tcgatcagaa gaaatcagga aaaggcatcc tggataagtt 1103941 gagatcgatt cgtgatgagc agctgagcca aacagcagaa ggcaaagaac tgacaagcct 1104001 ttattacaaa gcagcaccgt ttatcgttgc aaagctcgca ctcaataaaa cagcaagaaa 1104061 tgaaatctat caggatcttg tgacattaaa gccgttattt gacgatgtgt cagaaaacgg 1104121 agcatcatct tcgtataagg tcactgaaaa ggatcaaaaa gcgatcaacc ggctatatga 1104181 taaagcttta caatcagtcc cgtcattcct taaagaggag ataaagaaac aagcggaccg 1104241 actaaatatg aagcagctgc aaggcaaaac agcaggagcc attttaacag aaaacaatat 1104301 tgcagcaaaa agtgaagttc agacaacaaa ggttattttc aaggtgaagg acaataaaag 1104361 cctctcatcc gtacataatg aaatgaaggg cttttctgca agcgcgcaat cgaaaaaaga 1104421 catatctaat gtgaaaaagg caaagaaact gtttgacaat ctgtattcat ttgaacttcc 1104481 gaaagacgag aaacagaacg gcgcatatac ggcaagcgcc aaaagggtca aaagcgctgc 1104541 tgcgacacta tccaagatgt ccaatgtaga gtttgcggaa cccgtacagg aatacaaaag 1104601 cttggcaaac gatattcagt acccttatca atggccgctt aaaaacaacg gtgaaaacgg 1104661 cggtgtcaaa aatgcggatg tgaaatatga gcctgccaac acattgctgt ccaaacgcaa 1104721 gcttaacgat acactcattg cagtagtaga cacaggcgta gacagcacgc ttgccgattt 1104781 aaaaggaaaa gtaagaacag atctcggaca caattttgtc ggacgaaata acaatgcaat 1104841 ggatgatcag gggcatggga cgcatgtcgc aggcattatt gcagcccaaa gcgataacgg 1104901 ctattcaatg actggattga atgccaaagc aaaaatcatc cctgtaaaag tgcttgattc 1104961 cgcaggttcc ggagatactg aacaaattgc tctcggcatc aaatatgctg ctgacaaagg 1105021 agcaaaggtg attaatttaa gtttaggcgg aggctacagc cgcgtgcttg aatttgcttt 1105081 gaagtacgca gctgacaaaa atgtcttgat tgccgcagcc agcgggaatg atggagaaaa 1105141 tgccttatct tatcctgcat cttctaaata tgtgatgtca gtcggcgcaa cgaatcgcat 1105201 ggatatgacc gctgatttct ctaactatgg aaaaggtctg gacatctctg ctccagggtc 1105261 tgatatcccg agcttagtgc cgaacggaaa tgtcacgtac atgagcggaa cgtctatggc 1105321 gacgccatat gctgccgccg ctgcgggact gctgtttgct caaaatccta agctaaaaag 1105381 aacagaagtt gaggatatgt tgaaaaagac ggcagatgat atttcctttg aaagtgtcga 1105441 tggcggagaa gaagagttgt atgacgatta tggcgatccg attgaaattc cgaagacacc 1105501 tggtgtagac tggcattcag gctacgggcg gctgaatgtc atgaaggctg tcagcgcagc 1105561 tgatttacag cttaaggtca acaagctgga aagcactcaa acagctgtca gaggaagcgc 1105621 gaaggaaggc acccttatcg aggtgatgaa cggcaaaaag aaactcggca gcgccaaagc 1105681 cggaaaagac aatgcgttca aggtgaatat cgcgactcaa aaacaggatc aagtactgta 1105741 tctgaaagca acaaaaggcg atgcgaaaac atcgtataaa gttgttgtcg tcaaaggaaa 1105801 accttccggc acaccgaaag taaacgcggt gaaaacgaag gatacggcag taaaagggaa 1105861 ggcaaacagc aaagcgatga tcagagtgaa aaacaaatca aagaaagtca ttgcttctgc 1105921 caaagctgac gcaaaaggaa cgttttcggt gaaaatcaaa aaacaaaaag ccggaacggt 1105981 gctgtacgtc acggctgtgg atacagataa aaaagaaagc aaggaagcaa aagttgttgt 1106041 tgaaaagtaa ccaaaaagcg gtgctcgatg caccgctttt ttatttgcgc ccccgttgga 1106101 ctgctgtgta cataatggat cgctttccgt ttgaagccgt ccattcaaaa cggtctcctg 1106161 tcccttcgct gctgtagttg tagtgatgct gcatcgcgca ttgtgcggtg tcatttgaaa 1106221 agtgataaaa ggacacaccc tgccccgccg aagtattcga aaagactcct ttattataag 1106281 aaaagacgca atcgaatacc gataagccga agctgtgcaa gtgctgcaga aatgcgagaa 1106341 aggtttcgtc gtcaagcgaa tccaaaagcg ccatgagcgg ccgcttgact gatttctcat 1106401 agcggatgcg ttctccgccg gaaagggaga tgttttctgc accgcatgcc aaaaccaact 1106461 tgtcctgaaa gccggcttgc tcccactttc ctttatgatg gatccagatt gggctgtgtt 1106521 ggagactgtc cgccagcagt atatcgcctt caccgttttc gattaagcag atgccgtctt 1106581 caatgaggat ggtgccgtat tcccactttc gttcctctgt atataacaat tgtttccgtt 1106641 tcatccatgc tgtctccttt ttcttcattc ctctcttttc tttccaattc aagcctgtcc 1106701 catacaactc ttttatggac aaatcaacta tctgcctata gatgcataaa cttactaagg 1106761 tgctgaaaga aacgaaattg ttacgaaaga aacgggattg gagctgatgt cacatgtgtg 1106821 gaattacggg ttgggtcgat tttaaaaagc agctcgtcca ggaaaaacaa acgatggaca 1106881 gaatgacaga cactctttcc aaacgagggc ctgatgattc aaacgtttgg ggggagcacc 1106941 atgttttatt cggacataaa agacttgcgg ttgttgatat tgaaggcgga cgccagccga 1107001 tggcgtgtac ctataaaggc gatacgtaca ccattattta caatggcgag ctttataaca 1107061 cggaagattt gcgcaaagaa ttgcgggcgc ggggccatca attcgagcgt acgtcagata 1107121 ccgaggtgct tctgcacagc tacatcgagt ggcaggaaga ctgtgtcgac catctcaatg 1107181 gcatattcgc tttcgctgtg tgggatgaaa agcgtaatct gttgtttgcc gcgagagacc 1107241 gtctcggtgt aaagccgttt ttttacacga aggaaggctc ttcatttctc ttcgggtcgg 1107301 aaatcaaagc aatcctcgcg caccctgata taaaagcgcg agtggacaga acgggacttt 1107361 ctgaaatttt cggtcttgga ccgtccagaa ccccgggcac tggcatattt aaaggcataa 1107421 aagaaatccg cccggctcac gcgctgacat tttccaaaga cggacttaat atttggcgtt 1107481 attggaatgt tgaaagcgaa aaacatacgg acagttttga tgacacggtt gccaatgtca 1107541 gatcgttatt tcaggacgcg gtgacgcggc agcttgtgtc ggatgtgcct gtttgcacat 1107601 tcctatcagg cggtctggac tcaagcgcga ttacagcgat tgcggcgggc cattttgaaa 1107661 aggaaggaaa agcaccgctt catacttatt cgattgatta cgaagagaac gataaatatt 1107721 ttcaagcaag cgcttttcag ccgaatgatg acggaccatg gattgaaaaa atgacagagg 1107781 ctttcggcac aacgcaccac aaatgcgtca tcagccaaaa agacctcgtt gatcatttgg 1107841 aggaagctgt actggtcaaa gacttgccgg gaatggcaga tgtcgactca tccctgctgt 1107901 ggttttgccg ggaaatcaaa aaggactttg tcgtcagcct atcgggagaa tgcgcggatg 1107961 agattttcgg cgggtacccg tggttccata cggcagatgt tgagtctggc tttccatgga 1108021 tgagatcaac ggaggagcgg atcaagctgc tttctgactc atggcagaaa aaattgaatc 1108081 tgaaagaata cgtaaatgcc aaatatgaag aaaccttggc agaaacgcca ttattagacg 1108141 gagaaacggg tgtggataaa gcaagaagac agctgttcta tttaaatatg ctttggttta 1108201 tgacgaacct tttggatcgg aaggatcgca tgagcatggg ggcgagcctg gaagtgcggg 1108261 tgccgttcgc cgatcaccgg cttgtggaat atgtttggaa tattccgtgg gaaatgaaaa 1108321 tgcatgataa tcgggaaaaa ggcattttgc gcaaagcgct tgagggcatt ttgcctgatg 1108381 acattttgta tcgcaaaaaa agcccatatc cgaaaacaca tcatccggaa tatacaaaag 1108441 gcgtcagcga gtggctgaaa acgatcagaa gccaaaagga ctccgtgctc cataccttac 1108501 tggacagaaa acaattagat cagcttttag aaacggaagg ctcctccttc aaggtcccgt 1108561 ggttcgggca gctcatgaag gggcctcagc tgatcgccca tcttgctcaa attcatacat 1108621 ggtttgaagc gtatcgcatt gatattgacg agaggtaggt tcaatacaaa tgtgattaaa 1108681 agccagagat gtatagattt aaataagaag gatagatgag cagggaaata tatgctctat 1108741 ctatcctttt ttgtacaaca gcactatcga attgcccccg cattccttca ataagaatga 1108801 ataggtttta atgttctgcc gataaaacta gctgataccg ggcttaactt taattcccta 1108861 gcccatacag aaagttgacc aatatggtga atttcgtgag cgatgatatg gtgtaatatt 1108921 tcatctcgcg tatataaaac acctgtctcc caaggaacgc ttacaagttc atcttttatt 1108981 tgatctgaat gtgtttgtaa aacatcaatt atttcagttc ggaatgtatt tgagagagat 1109041 ttcactttat tgagtgtttg ataatcagcg aactgaacag cgatatcttc ttttccttgg 1109101 atagcacgaa tccaactata ttccacatca ataatatgaa aaagggtata taaaatattc 1109161 tctactccgc caagacgatt tttaagtaat tcttcagtgg ttagttgatg acaccaagta 1109221 aaccattgat ctctaacctg ccagttatat tcaaaaaatt tcatcactaa actcactcca 1109281 atactatcat gtatcataac aattagccct tttttccgtg attcctctat taatgaagtg 1109341 atgattgaga aatgtttaca ttctacctgt tgtatggcat taaaaataat aatgcatatc 1109401 tcgtcgatga tgctgtgcgt cttgttactt ttacaaagta agaatcggca ttttcttcat 1109461 atacaattag gaaaaaacat actagacttg aagaagcagt gatacatagg agtgagaaaa 1109521 tgaaagagat aaaagaagct taccagcaat gcggacagat tgttggcgaa tacgcgccag 1109581 cctgtttcaa agcattatca tatctcccgc taaagcaaag acaagcctct tgggcagtat 1109641 tgtcgttttg ccacacggcg gccagtgcag acgaaaaggt attgcccgca tttgaagcta 1109701 aagctgatca tgtttaccaa aggacaaata acggtaaaca acatctatgg aaggcttttg 1109761 atcatgcgta tcggaccttt acattggaaa gcgaaccttt tcgggagttt attgccgcac 1109821 aaaaagaaga cgccaagccg tatgatgacc ttgatgaact gctcatgtac gcatatcgga 1109881 cgggcggtgc tgccggattg atgctgctgc cgatactgac acgccgaaaa caagatcagc 1109941 tcaaacaagc agccgtctct ctcggcttgg ccatacagct ggttcgcttc ttaagtgatc 1110001 ttggcacaga tcagcaaaaa aaccgcattc cccgtcaggt aatgcagcaa ttcggctata 1110061 cagaggctga tctccaaaaa ggcaccgtaa ataaagcgtt cacaatgacg tgggagtata 1110121 tcgcttttga agcagaagcc taccttgaag agtgtcagga tgccttgccg ctatttccgc 1110181 agtattctca aaaaacggtg aaagccgctc ttcatttgca ccgggctgtt ttagaaaaaa 1110241 tccgggcgaa gcagcacgat gtatttcaat atcacttcgc tctcacagag accgaagtga 1110301 agcagattct gtctgatatc taaaaaacac ccggccttga ttgagccggg tgttacgcca 1110361 tacctttttg aatccagata cgtgagcgcc atcttctgta cattaagatt ccccggaccc 1110421 attcatccgc gataaaagaa atccaaatgc cggcaagacc gaaaccgagg tggatgccga 1110481 aaagataagc aagcgggagg ccaatgcccc acattgaaat cattgccatg taaaccggga 1110541 atttcgcatc ccccgcggcc cgcagagagt taatgataat gacattaaac gagcggcctg 1110601 gttcaaggat aatggtcatg gcaatcaata ggcttgcagt tgctataatg tcagggcttt 1110661 gtgtgaagag tccgatcagg tcttttgaaa agatcgtcat caaaacagag gtagccgcag 1110721 caattccgag tgcccaatat aagctcttca tgcagcgctc ataagcggca tcaaattgtt 1110781 tgccgccgat ataacggccg attaagattt gtgtaccctg gctgatcgca gtgccgaaca 1110841 gcaaaataaa catcgtaata ttttgcgtat acacttttgt tgtcaacgcc tgcgcgccca 1110901 tgatggcgat aaaatacgtg actatcattt gcgacaggtt gtatgaaagc tgctctcccg 1110961 cagaaggaat gccgattttc agcagcttgc gcaaatgctc tttatgcata tgaaagactt 1111021 ttttcagcga catcttcagc tggatgcgtt tgttgacaat cacaatcatc gcgattaatc 1111081 cgatgacgcg ggcgatagat gtggacatgg ccacaccggc aacaccgaga acaggaaagc 1111141 cgaacaaacc gaaaatcaca acaaagtttc cggcaatgtt taaaatgttc atgccgatag 1111201 tgacaaacat tgtatctttt gtgtagccgt agctttttaa gatcgcgctg aatgtcatga 1111261 ttaaagcctg aataaaggac agacctccga caacttgtaa aaagactttc gcatcaggca 1111321 tcagtgcgtc tgataatccc atcatatgaa gcagagggac agccgcgaaa aagacgacgg 1111381 cgctgatggc caggctgatg aagaagttgg cgccgattga cacataagcg acttccatgg 1111441 cttctttctt ttgccgtgag cctagaaatt gtgaaatgat aacggtcgtt cctgttgcga 1111501 taaagctgaa catcacgata attaaattta aaatctggtt gctgacgccg actgctgcca 1111561 cgctgttatc cgagtattgg ctgagcatca gtgtatcggc attacccata aacatatata 1111621 atgagacctc aataaagatc ggccaagtaa gcgaaaataa tgagaacgtt ttgtcagcgg 1111681 gttttttcaa agcagttgat ttgaagacag cttgtttcat cgtgtctaac ccctttcgta 1111741 aataaaatca acgttttaaa gtgtacctcc atttccttat aataaaaagg gatagaaacg 1111801 atacttcttg taaaaatccg acttaaaaag gaggatgatt caaatgcctc gcatcctgtt 1111861 tacagtcccg ccttttccgg tatttatcgc agctggggaa ggggttttta aaaaaggaga 1111921 aacccatgtg aaacgtgtat tctccgtgtt tgatctgata tatgtcaaac agggaacgtt 1111981 atatataacg gaaaatgaaa catcgttttc tgttgaaggc ggcgagtaca tcttgctttc 1112041 tcccggtctt gaacactacg ggacgaaggg cagtgatgaa gcaacctcct actattggct 1112101 tcacttcgat gaacatcgat atgaatttac ggcaaaggga ggcagcaact ggtctgagct 1112161 tcagcaggaa aaagggagct tcgaagagct ggcccgctac ggattggcct tgccgagaaa 1112221 aggcaaggtg cagcgcccgc agtttatggc gcagcagttt gaaaagctga tcgattactc 1112281 cgcggaaaac tctgatttgc cgctcagaaa gcaaatttta tttgaggagc tgatgctgca 1112341 tcttcaaaaa gaagcgttcc aaataccgtc tgcgaaagag cgggtagcct gggaggcggc 1112401 ccggtattta caggagcact ataaggaaaa gacgacaatc aaggatctgt cgctcgccct 1112461 tcactatcat caggattatg tgagccgctg catgcagcag gtgctcggcg taactccggc 1112521 acaatacacg aaccgggtga gaatgacgga agcgaagcgt cttttatcct ctacaaatga 1112581 taaaatgggc gttattgcgg aaacggtcgg aatggaagat ccgacatact tttcaaaact 1112641 ctttaagcag atagaaggca tttcaccaat tgaataccgg aaaattgtca gccggaaagt 1112701 tcaataacca gacgagggat gaacatgaaa acaacaattt acgatgtggc aaaggcggcg 1112761 ggtgtttcga tcacaactgt gtcccgtgtg ataaacaata cggggagaat cagcgataaa 1112821 acacggcaga aggtcatgaa tgtcatgaat gaaatggcat acacgcccaa tgtccacgcc 1112881 gcggcgttaa cgggaaaacg aacgaatatg atcgctctcg tggcgcctga tatttcaaat 1112941 ccgttttacg gcgaactggc caaaagcatt gaggaaagag cggatgagct cggttttcaa 1113001 atgttgattt gcagcaccga ttacgatccg aaaaaagaaa caaagtattt ttctgtgctg 1113061 aaacagaaaa aggtggatgg cattattttt gcaacaggga ttgaaagcca tgacagtatg 1113121 tctgctttgg aggaaatcgc cagtgaacaa attccgattg ccatgatttc tcaggataag 1113181 ccgcttcttc cgatggatat tgttgtgata gacgacgttc gtggcggata tgaggctgcc 1113241 aagcatcttc tgtcactcgg ccacacgaac atcgcctgca ttatcggaga cgggtcaacg 1113301 acaggcgaaa aaaatagaat caaaggcttc cgtcaggcga tggaggaagc gggcgtgccc 1113361 attgatgaat cacttatcat ccagacgcgg ttttccttgg aaagcggcaa ggaagaagcg 1113421 ggaaaattgc tcgacagaaa tgctccgact gctatttttg ccttcaacga cgtattggct 1113481 tgtgccgcca tacaagctgc gagaataaga ggcataaaag tgccggatga tctttctatc 1113541 attggttttg ataatacgat actcgcagaa atggcggctc cgcccctgac aaccgtagcc 1113601 cagccgataa aagagatggg gcggagcgtc atcgaactgc tggcagaagc aatagaggga 1113661 aaacgaaagg cgaaacaaaa aatagtgctc ccgcctgagc ttgtagtcag acattctaca 1113721 tcaccgctca acacatgagc ccgctaatga gcgggttttt tcattatgac agttgaagcc 1113781 aaaaaaacat attgcgtgta aaccaaaggc ggtgtaaaat ataaccatct tttgagaaag 1113841 cgcttgcgca aaatggcaga gcggatagaa ccgctgtttt tttagctgtt aagagaaaac 1113901 gctttctcaa agcgagcccg aaatgagata aaggagagga tgggacgtgg aacatcaagt 1113961 aagatgtgca gtattgggat taggaaggct cggttattat catgcgaaaa atctcgtcac 1114021 cagtgtgccg ggggcaaagc tggtttgtgt cggtgatccg ttaaaaggga gagcggagca 1114081 ggttgccaga gaactcggta tcgaaaaatg gtcagaggac ccgtatgaag tgttagaaga 1114141 tcccggcatt gatgctgtca ttatcgtaac gccgacaagc acacatggtg atatgatcat 1114201 caaagcagcc gagaacggca aacagatctt tgttgaaaaa ccgctgacat taagccttga 1114261 ggaatcaaaa gcagcttctg aaaaagttaa ggagacaggt gtcatctgcc aagtcggctt 1114321 tatgagacgg ttcgatcccg catacgcaga tgccaaacgg cggatcgacg ctggagaaat 1114381 cggcaaacct atctattata aaggctttac gcgcgaccaa ggcgcgcctc ccgcagaatt 1114441 tatcaaacac agcggtggaa tttttatcga ctgttccatc catgactatg atattgcccg 1114501 ttatttgcta ggggcggaaa tcacttctgt ttcaggacac ggcaggattc tgaacaatcc 1114561 gtttatggag cagtatggcg atgtggatca ggcgctgacg tatattgaat ttgactcggg 1114621 cgcagcgggg gacgtcgagg caagcagaac ctctccatac ggacatgaca tccgggcgga 1114681 ggtgatcggg acagagggca gtattttcat agggacattg agacatcaac atgtgaccat 1114741 cctatcggct aaagggagca gttttgatat cattccagac tttcaaactc gttttcatga 1114801 agcctactgc ttggagcttc agcatttcgc cgagtgtgtc cggaatggaa aaacaccgat 1114861 tgtgactgat attgatgcga cgatcaattt agaagtgggt atcgccgcaa ccaattcctt 1114921 tcgaaacggc atgccggtac agctagatgt gaagcgcgct tatacaggta tgtaaaagct 1114981 aagtatgttg catttgaggc tttccgcaaa aaaagcaagg gcattttagc ccttgctttc 1115041 tcttttctca tataaatagt acatataatc agtaggtacg cctgaatggt ccagctgtct 1115101 cagcatggcg gttacgttcc ctctgtggta agtgccgtga ttgacgacat gcaggatggt 1115161 gtctgcatag gttgattcca gtgtacctag tttcggatgc tgcattgtga aggtctgttc 1115221 taagtccgtc tggcggctga agaaatcatg atactgtgac tccagctcgg cagcgtgctg 1115281 tttaatcgct gccatattac cttgcgcgga ctgtaatttg cctgcgctgt ctataatctc 1115341 ttggtaggcc actcccgaaa gaacattcag ccaaatgtag tcagccctgc acatatgaag 1115401 cagcacgtcg ctgacagaag gaaatacgct ctttacttct tgataggcag tttcctccgg 1115461 caggttttcg atatgggtaa atattttctt gtttgcccaa gaatgatagt cataaaactg 1115521 ttttgcatca gtcatcagca tgcccccttt tctaagaaat tcgttttttt catctgtttc 1115581 tccttcaatt gcaaaagagt gacaccccaa aatatcctgc cgctgcccac attaccgctg 1115641 cagagcattt gtttacgatc agcataagcc tgccgctcgt atctatcgtc tgaaacaacc 1115701 ggcccgctat tgcaaggctg atgaaccaaa tccaagacac agcgatgcag gcggccataa 1115761 agagccattt ctcaagcccc gaatattgaa gagagctcgt gccgatgacg ccgatcgtgt 1115821 ccagaatggc atgcgggttt aaaagagaaa cagcggccgc aaacgcagct tgcttttttg 1115881 gtgtgaacgt atgtttctca ttttggcttg tgttcggacg gatgttccaa gtcacccagc 1115941 ccatataaag caaaaataaa aatccgccgg ccatcatgac tgtctcaaac acaggcagct 1116001 cctgcacaat gacagacacg cccgcaacgg ctaatacaat taacaaggta tcgcagactg 1116061 aagcactgat gacagctggg agagcccgcc aaatatgctt ttgcaacgcg ccttgctgaa 1116121 aaataaacac attctgcact cccagcggca aaattaagcc aaacgcgagc acaattccgt 1116181 gaatgattgc attcatgctg aaaaagctcc tttcacattt tttttcaatc ataagagaga 1116241 ttgtcactaa agtctccagc catttggttg ggttaggaac cagccaaatg tataatgtgt 1116301 aaaaaagggg ggcatgacct tgtcgcaatg gcagccaagc cgaaagtcgg atgttccgct 1116361 gcatcggcag atcgaacaat atatgaaaga caagattctt cacggagagt gggctgtagg 1116421 gacgaaaatc ccctcacaga gaacgctggc cgacatgttt caagtcaacc gcagcacagt 1116481 cacagcagcc atagatgaac tcacgtctca aggcttgtta gagggaagaa aaggcggcgg 1116541 tacgaaggtt gtaaacagta cttggagcgt gctgacggct gagcctccgc ttgattggag 1116601 cgattacgtc cgttcgggca ttcatcgcgc caattcttcc atcattcaag ctattaatca 1116661 gaacgaacca agagcggata tcatcagatt aggaactgga gaactttcac cggatcttgt 1116721 gcctgctgac acaattggac ggatgtttca gcaaatcaat ccgggcgtcc tgtctttagg 1116781 atatgagcag ccgaaaggaa accgtcagct gcgggaggca gtggccgacc atttaaaagg 1116841 aaagaagatc catgtgtcac cgtctgcaat tttaattgtg tccggtgcac ttcaggcact 1116901 tcagctcatc tcaattggac ttttaaaacg agattctgtc attttgacgg agaagccgtc 1116961 ctaccttcaa tccttgcatg tatttcaatc agctgggatg cggcttcgcg gcttgccgat 1117021 ggatgatgaa ggggtcaaag cggggcttgt ttcttctaat cgaaaacaat atggaggaca 1117081 gctgctttac acgattccgt cgtttcataa tccgacaggc acagtcatgt cagagcagcg 1117141 aaggaaagag atcatcagcc tgtcaaaaaa agagcagatg cccatcattg aggatgatgc 1117201 gtacggtgat ttatggtttg aagaaaaacc gccgcagccg ttgaaagcaa tggatcatga 1117261 gggcaatatt ctgtatctgg gcgcgttttc aaaaacggtt agccccggtc tgcgaatcgg 1117321 ctggcttgcc ggtccggagc cggttattga aaggctggcg gacattaaaa tgcagacaga 1117381 ctacggatca agcggcctgt cccagtgggc ggctgccgag tggctgtcac agggatatta 1117441 tgaagagcat ctgacttggg tacgcaggaa gcttaaagaa aggagagacg ccgccgttca 1117501 ttttctcgag cggtatgccg gggacattgc cacgtggcgg attcccgcag gcggctttta 1117561 tatttgggtg acatttcaca aaaacctgcc tgtcagccgt ttcttttatg aattgctgaa 1117621 acggcaggtg cttgtgaatc ccggctatat ttatgacggt gaagaccgaa acagcatcag 1117681 gctgtcatat tcctatgcat ctcttggaga tttggaaact ggcattaaag cggcagctga 1117741 aacagcacgc cgcctgatga tgtcctaggc tttggttata cgatgacagc tcccagtgcc 1117801 ctggcgaagg caatcgcgtg ctcaggtgcg attttgcagc ctttcaattt gtcgagggag 1117861 acatgaagct gttcaaaacg gcacgtgctg atgtccatgt tttgaaggga cgtgccggta 1117921 aagctggcgc cttccaattc gcatccgtca aagtgtgtct gctggagcac cgtatcgctg 1117981 cattcacttt gcataagagc acagtgatca aatcgaactt gtttcatatt tgagtacgaa 1118041 aatgagctga aatgtccgtg gcattcctcg aatgaaacat tccgcagcgt tgcttccgcc 1118101 acattcattc caaccatttt tgactgctta actgaagttc tgtgaatgac agccccgctg 1118161 aaatcggcgt ttgataaatc gcatttttca aagatcacat cggtcagttc aatatgccga 1118221 aaagacacat cgataaagac gacatttctg aataccgttt tttcaacaca tagtctttcg 1118281 atatcttcgc cgcagatggt gcaatcttca aacaaatgca tgctgattac atcatcctgt 1118341 gtcacggcat catgaaaatc tgcggtttgc aggttttccg gtatgttcgg tttttgaatt 1118401 gcgattttat tcatgtgatg acatcctttg ctgcccgaaa aacagaggct tccgggttca 1118461 atttaataga tcgttaagga aattgataca tatagtaaat cgtgaagagc cttttcttgg 1118521 tacagcagcc cgcttgtttt gtaagcataa atggaaagct tcctatacgt caaggcgttt 1118581 acaggccgaa aaagccaaag ggaacaggag gaatgcggaa tggggcatta catcaaaacc 1118641 gaggagcatg tgacactgtt tgtagaggat atcggacatg gaaggccgat catctttttg 1118701 cacgggtggc cgttgaatca taagatgttt gaatatcaaa tgaatgagct tccgaaaagg 1118761 ggatttcgtt ttatcggcgt tgatttgcgg ggatatgggc aatctgaccg cccttgggaa 1118821 ggctacgatt atgacacgat ggccgatgat gtgaaagcag tcatttatac gctgcagctt 1118881 gagaatgcga ttcttgccgg tttttcaatg ggcggcgcaa ttgcaatccg ttatatggca 1118941 aggcatgaag gagccgatgt tgataagctg attttactgt ctgcggcggc ccccgcgttt 1119001 acaaaacgcc cgggttatcc gtacgggatg aggaagcagg atattgacga tatgattgaa 1119061 ttgttcaaag ctgatcggcc caaaacactg gctgatttag ggaaacagtt ttttgagaaa 1119121 aaagtgtctc cagagcttag gcagtggttt ctcaatctga tgctggaggc ttcctcctac 1119181 gggacgatcc actcgggcat cgcattaaga gacgaagatc tcagaaagga acttgctgca 1119241 atcaaggtgc cgacgctgat cctgcacggg agaaaggata gaattgcgcc gtttgatttt 1119301 gcgaaagaat tgaagcgcgg catcaaacag tcggaattgg ttccgtttgc aaacagcggg 1119361 cacggagcat tttatgagga aaaagagaag atcaacagtt tgattgcgca gttctccaac 1119421 tcataagaaa aaacccgaca ttgatcgggt tttttatata attcctctgt tttgcagtgc 1119481 gttaatgatg agatcagctc catcggaaat agaggtctgg tcagactcaa tgatgaaatc 1119541 gggtgaaagc ggcgcttcat acggagaatc gatcccggtg aaatgtttga tctctccgtt 1119601 tcgcgctttt ttataaagcc cttttggatc gcgctgttca caaacatgca gcgggcactt 1119661 cacataaatt tcgaagaact cacctttagg aaagagcgct ctaaccatgt cccgatcctc 1119721 tctgaatgga gaaataaaag ccgttaaaat catttgcccg ctgtcgacaa acagcttcgc 1119781 cacttctccg atccggcgga tgttttcaat cctgtcacca gtctgaaatc caagatcttt 1119841 gtttaagccg tggcggatat tatcaccgtc aagcacgtag ctctgaatgc ccttgcggta 1119901 aagcttttca tcgacagcat tggccagcac cgattttccg gagccggaca aacctgtaaa 1119961 ccaaaggacg cagcttttgt gtccgtttaa ggactgtctg tcagactttg agatggcagc 1120021 gggatgccaa atgatgttcg gattgtgtgt cattgcaatt ccccgctgtt ttgcttgatg 1120081 gcaacaggct gttggtgaag tcccttgatc agcacggctg cgacctcagg ccggctgaat 1120141 tctttaggcg gctttttgcc ttggcggaga agctctctca cttttgtgcc tgataagtgg 1120201 atgtggtctc tcgggctgtg cggacatgtt ttggaggtgc ccatgtttcc gcattttcgg 1120261 caataaaagc tgtgctcaaa aaacagcggc ttgatgccca gctcttcctc tgtgaatgat 1120321 tgaaaaatat tttgggcgtc gtatgttcca tagtagctgc cgacacccgc gtgatcacgg 1120381 cctacaataa aatgggtaca gccgtaattt tttcggacga gcgcatggaa aatcgcttcc 1120441 cgcggacctg cataacgcat ggcggcaggg aaaaccgata acatgacacg atcctttgga 1120501 taatagtgat taagcaaagc ctggtagctc tccattctga tatcgctggg gatatcgtct 1120561 gactttgttt ctccgacaag tgggtgaagc agcagaccgt cgaccgtttc taacgctgtt 1120621 ttttgaatgt attcatgcgc tctgtgaaca gggttcctgg tttgaaagcc gacaatcgtc 1120681 ttccagccga gtttttgaaa ggccgctctt gtttcagcgg gcgttgcata aaactgttcg 1120741 aaagatttgt caggcaggct gctgaccgtg ataggccctc cgatatagta atccgggcgc 1120801 gccagcaatt tttttacgcc tgggtgggca ggatcgtttg ttttaaaaac agacagtgct 1120861 tcttgtgttt tatcaggctg gtatatatcg gtgactgtga tcatgccgta ggtaacaccg 1120921 tctttcacaa gcttgacgtg atctccggca gacagctgtc ttgctgtttt ttctccgaca 1120981 ggcagcgtaa tcggcaggct ccacggcaag ccgtttgcca gcctcatctc tttcacaacg 1121041 gaatgataat ctttttctcc caaaaaacct gttaacgggc tgtagccgcc gatcgcaata 1121101 agctccagat cactcagtgc aagctgatcc agctctgctt ggcacgcgca cccttcaaaa 1121161 tggcatgcgg gatcacagcg gttgattaat acccctccgt ggggttcgtt tccattcaac 1121221 gtgttcaacc tccatttata cgtttccttg ttttcttttc tgcacttaat gaaagtttga 1121281 catcagcgcc ttaacatcat ttcgattctc acatcaagaa cctgccatcc gctattcttg 1121341 atgcaggccg cattctgttt tctcccgtcc ggcccatctt ccagccctct catcgttcgg 1121401 gtccggggaa ggcagtgtac acatttcaca gcctatgctc ggataatgtt gatcgtgcag 1121461 tttgttataa ggcaaattgt gcaggcggat gtacgtccaa acgtcatccc atgtccagtg 1121521 gataagcggg caaattttga tgagctcaaa cttctggtcc aggtttacgt attgaatatg 1121581 ctttctcgtt ggtgactgat cccggcgcag tcctgaaatc caagctgtca tgccggacag 1121641 gtgctttttg agcggttcga ttttccgcaa ttggcagcag aggttcgggt tatgcttcca 1121701 cagctctccg ccgtacttcg tcccctgttc tgttaagctc agctcgggtt cgagcatctg 1121761 gattgcaaat cccggatatc gttctttgac ggtctcgatc agctcatatg tttcctgaaa 1121821 atgaagcccg gtatccaaaa agatgatgtg tgcgtttttg ttgatttttg atattaagtc 1121881 gagaagcacc attccttctg cgccaaagct gcaggcgtac acaatctttt ctccgtacgt 1121941 tcggtaagcc catttcaaca catcgagctc atcgatcaat tgatccgtta tctgtttgga 1122001 cagcatgtcg ttccaagtgt catatgtgat ggtttcgttc aatgttttcc ccccgtttgc 1122061 atctgctttt tttatctatt gatcgagtta taggcagact attcattttt tgcataaagg 1122121 ttcaggtttt aggtgccgcg cccgcctaaa atgaggtgcg gaaccattaa gagcccggct 1122181 gaatatgctt tttagcaaaa tggttttatg cccaaggaga ggtagtatgc cgattgccat 1122241 ttatcagggg catcatcatt cgcttgcccc ggcggacatt aacatcgtca ttgatgtcat 1122301 cagagccttt acggtcgccc attatgcgtt tatcggcggg gcgaaagaga ttttgttggt 1122361 ccggacagct gatgaagcct ttgcgctgaa agacacctat ccggattatg ttttgacggg 1122421 agaggaaaag ggggtcggta tcagcggatt tgatttagat aattctccaa aacgtatggc 1122481 tgggcagaat atgacggata aaagcctgat ccagaaaaca acaaacggcg tcacagcagc 1122541 attgggggcg ctgaacgcaa agcatctgtt cgtaactgga ttttccaatg ccaaaacaac 1122601 ggcacagcat gtgaaaaagc tcgtcgcaaa cgattgtgtc ataaacatag tggcttccca 1122661 tccatccggt gatgacgata tggcatgtgc ggagtatatc aaaggcatca ttgaagggac 1122721 aaatgtggta acggctgcgg aggcgattga aagaataaaa ggctcttctg ttgcggagaa 1122781 gttttttgac tgccgccagc cattgtttga ttcggaagac atcgtttact gtacaaaaga 1122841 actgacgggc gatttcgtga tgaaagtgaa acaagatgga gaagttccaa cgatagagag 1122901 ggtcataata tgaatgattt ttcactagaa ttgccagtga gaacaaacaa gccgagagaa 1122961 accgggcagt ccattttaat tgataacggc tatcccttgc aatttttcaa agatgcgata 1123021 gccggagcgt ccgactatat tgattttgtg aaattcggct ggggcacatc attacttacg 1123081 aaagatcttg aagaaaaaat cagcacactg aaagaacatg acattacatt tttctttggc 1123141 ggcacactgt ttgaaaagta cgtaagccag aaaaaagtga atgaatttca tcggtactgc 1123201 acctatttcg gctgtgaata tattgagatt tcaaacggta cgctcccgat gacaaataaa 1123261 gagaaagcgg cttacattgc cgatttttct gatgaatttc ttgtgctcag tgaggtgggc 1123321 agcaaggatg cggaattagc aagccggcaa agctctgagg aatggcttga atatatcgtt 1123381 gaggatatgg aagcgggcgc ggaaaaagtg attacagaag ccagagaaag cggaacggga 1123441 gggatctgtt ccagcagcgg cgatgtcagg tttcaaattg ttgacgacat catttcctcg 1123501 gatattgata tcaacaggct gatttttgaa gcgcctaaca aaacgcttca gcaagggttt 1123561 attcaaaaaa tcgggccgaa tgtgaatctt gccaatattc catttcatga tgccatcgcg 1123621 ttggaaacgc tgcgtttagg gctaagatcc gatacctttt ttctgtaaaa tagcggctgc 1123681 ggggctctcg tcgtgaagag agcctctgcc tattattttt tatggcggta cataggcgtg 1123741 agatagggaa gtgaggtcag gcggatgttg tagatgaagt cgatgactct tgtcgatatc 1123801 acctggcata tgagggcttg aatgacgatg ccccagtcaa taatagacgc ggtgaccata 1123861 aaaatgatgc aattcatgat gagcaggatc gttccaggat tcccgccgcg gtagatagaa 1123921 atcatcagag caagggctcc gaatcctccg ttcgaaattt tatatttgta taaaagtccg 1123981 attccgagtc ccaataacac tgcgccgctt gccagatcaa gccacaggtt agatgtgata 1124041 tcaggaaaaa ctgcatcaaa gatcaatacc gagacagagg tgacggtgat agaagcgagg 1124101 gtgccggtga atgttctcat ctccagccat tttaaagcgg taaaaagcat tgatacattc 1124161 acagcccaca ctgaaaatcc gtgggggatt tgaaacagat aatgcaatag caccgcaata 1124221 cctgctgcac cgcctgtcgg aatatcatgc ggaaataaaa acaaggacat gccgagtcct 1124281 tgtagtacgc cgcctacgac aatcataaac gtaagttttg ctttcatcag cagttcagcc 1124341 attaagtcat ttgctccttt atgaaaagac ttgtccgctg ttttcatttt atgaggctgt 1124401 ccattattta tgtctcaaaa taaagaaatg gcccagctta ataggctgag ccatcccact 1124461 tgtagcgatt gacgatctcc atattgatct ctgtgccaat gccttttcct ttcgggatgt 1124521 ggaccattcc ttttgaaggc tgcaggctga cgagatctgt aaaaggattc tccatgacgt 1124581 cccactcgat cggttcaatg tgatcgttct tcattttaga ccatgggggc agacaggctt 1124641 gtgcaaataa agcatagagc cgtgagagcg atccgtcata tgcatgggcg gatgctctga 1124701 cgccgaaata acgcgcgagc tggaggcagt cccgaaactc atcaattccg ttgacatgca 1124761 tgacatcggg ctgaatgata tccaaacagc gctgtgaaag gagaggcaca tattgcgccg 1124821 ggcctttcat gttttctccg ccggcaacag gaacagacaa acggcttcga agcatagcgt 1124881 aatcctgcgg ctgatcaaag ggcaaaggct cctcaagcca gccaatgttc gtccattcgg 1124941 agaaatagcg ctcccattta aaagccgcag cggcatcgta gctttggttt gcgtccagaa 1125001 tcatcgtaat ggagctgcct gctgtatgct gcagcgcatt gatgtgccgg acatcctcct 1125061 tgaatgaagt cccgccaatt ttgactttga tttgctcaaa accttttttc aactgggctt 1125121 caacattgga gactgagcgg ctgatccatt gcggggagtc tgagtacgat tgaaaagacg 1125181 cgtacacagg aatctcctct ctgtatcgcc cgccccataa ttcgcaaacc gaacaatccg 1125241 cagctttggc tgcaatctct gtcagcgcca tgcttacagc ggaggccgcc cgctggtgcc 1125301 atttttgaat cgtgcgcact aatgacaggc ggctgccagc ctgttttcct aatagaaatg 1125361 ggatgatccg cttcgtaaaa ccgacatgga gagcagggag ccaatcaacg cattctcccc 1125421 agccgtctat cccgctttcg gtgataatcc tgatgagata acaagtccga tatcgtttaa 1125481 acccattggc atctccgtat ggcttttcta atcgatgaaa tagcggaaag gtttcaatcc 1125541 gtacaatttt cacactgggt gctacctttc ctcagcgggc tggagccgat tgccagccat 1125601 tttagggtct tctttttctt ttgtttcttc attgttttgc ttcacatgga tgagcatcat 1125661 cacaagaatc ccgacaacga gagtcaatcc cgcgatgctt aaaaacatgc cgggtctgga 1125721 ccattgcatc aggcggccga aaatcggagg accgatcgct acccctaaga aacgtacaga 1125781 gccgtacagc gaggtgacaa atccccgtct ttctttgccg acagccccgg taatgaaact 1125841 gttcacacaa ggaaggacaa gacctgagcc tatactgctc agtacaagaa cactgataaa 1125901 aaggacaaga ttttcaatga atgacagtgc cgcgtaggat acggtcatga acgccaatcc 1125961 aagtacgatc agctttttca ttaacgattg cttttgcccg attttgcttc ctgttgtata 1126021 ggacgtcaca cacataacca aaagcgggat cgctaaaatt aagccttttt tcacgccgtc 1126081 ggtgtcgtat gttttttcaa gaacatctga gagataaaac aggatgccga ataaagtaaa 1126141 caaacaggtc gcaccggcta aataagcggt aaacagccat ctgccttcat gtttaaagac 1126201 acttaacagc ccttttgcat attgtccgat tggtggcggt tctttttcct ttttcttttc 1126261 tttaataaaa atccaagtca gtacgatcga aatgatacaa aacacaggaa aggcaaaaaa 1126321 cgcgccatac cagacaagca gggcgatcag cgagccaatg atcggcgata gcactttccc 1126381 catgccgttt gaagcttcaa caaggccgag caccttgctc tcctgggcgc ctttaaacag 1126441 atctcccgtc agtgccatgg caattgggcc ggttccggct gccccgattc cctgtaacgc 1126501 tcgtcctgcc atgacccaag gataggcatt gtcaaaaaaa cctgccgcaa acccggctaa 1126561 caaaccgccg gcaccataca aaattaagca gggaataatg atgactttcc ttgagaatcg 1126621 gtctgcgaga taaccgacaa tcggaatcgc aaatgctgca atcaaggaaa atactgtgat 1126681 cacgagactg acttgaaatt gtgataaatg aagttcagat ttcatttttg gcaaaatcgg 1126741 aataagcatc gagtttccta gggttaatat taaagggatt gaaccgattg ccacaatcgt 1126801 cattccgtta ttttgttttg atgattccat ctcagagcac actccttttc ttctgcttag 1126861 aatgtccctg atggcttcgt ttattcagcg atcagacagc aaaaaaccga acagaagata 1126921 cctgttcggg aaaaaagagg gttaaccgag agcctgtgaa atcaaagcat ataagtgtcc 1126981 attttgaata ggcgcttttt tctgatagaa caaaatcgga ggttcatcat ctttatgaaa 1127041 tcccatttct atcaggctgt catgcagaga cgtgtgttca ctcggtatat cgattcgcat 1127101 cggcccttgt ttgccggccg ccagccttgt aattatctgt gctgcaacat ctgatgatgg 1127161 agcgatgata gggccgaatt tcaaattggc cggtgtctgt acagaaagtc cgtagccaat 1127221 gagctgtccg tcctgatttc tggcgatgat acattcgcat gaagcagaaa taagctgctg 1127281 caaaaggttt gatcgatctc cgccaaaggc agccagatcc gccgcggtta agtcgtgaaa 1127341 gtcttgttct ctaaaggatg tcagttcagc atcaagcttt tttgtataag gttgaaaact 1127401 gtgacagctg tactttcgca ctgaacctgc cgtatgaaaa cctgcttttt cataaagcgg 1127461 caaaccttct tttgtggcgc aaagcctgat ggcggtgttt tcatccgttt gggtaataca 1127521 ggcgtttacc atacgccggc caagaccgag ccgttgatat tccttgtcaa cgataacaag 1127581 gccgatagaa gtaagacggc caaacaaaaa caagccgatg caggaaataa tatcaccgct 1127641 gacattttga taaccgaaaa agcgtccctg ctgaacaagc agtttcagct cttgttcgcc 1127701 ataatccggc cacccggctt gcccgcaaag ccgcaataag ccggaaacgt gttcttcatg 1127761 aagcttaatc agttcatcta ctacgtccat aagatcacct gcttgttcta agtgttttgt 1127821 acatgacaat atgattgcca atgccgggaa tgtcaaatgg ttcgccaagt tccttccagc 1127881 caagcttggc atagtagccc ttgacatggt gtcttgcgtt gcaccatacc gcctgaacgc 1127941 cgctctccgc cagtttgtgc tccgcgtgtt tgatcagcgt gcttccagct ttttgatcgc 1128001 gatatccctc gagcgttgcc atgcctctca gccgatacgc agaggcttcc gttaataaag 1128061 gctgactttg cggggaaaaa gaagcgatgc tgatcagcgt tccatcataa aacacgccga 1128121 gatgaaagga gccttctgcg tgatcctctt tatatttgca ttgttcgatg gattgatggg 1128181 gacgcagaat gcgatgccgg atttcatatg tatcttccac ggaaatggtt ttgacttcga 1128241 gcataatgtt cctcctcatg attgtttttc tatatcgtaa cacgaatctc gttgaaaaag 1128301 actgcccgat tcgatcaggc agtcttttgg aaattaatgc aaaaagatat tttggcgctg 1128361 ctcatctttt tgctgaatat atgatgtgag ctcagcggtt aagtcagatc tgaggaaagg 1128421 cgttatcaag tagatgccgt taaacagctc gcatgccgta tccagcaggg agcgtgcaat 1128481 tgcaaggcct tccgcctttt gcttttcttt atcttcaccg gcatgggcca ttttttcgcg 1128541 aatcgtatca gacagcttaa tgccgggaat ttcattatgg atgaattcgg cattccggct 1128601 gcttgtcagc ggcatgatgc cgatatagat cggcgtcttc agatgttttg tttcgttatg 1128661 gatatcgaca agctgctgct cggaatagac aggctgagaa acaaaataat ctgcgccgca 1128721 atctattttt ttctcaagcc gttttaccgc tttatccaga tggcggacgt taggattaaa 1128781 tgcggcggca actgagaaat tcgttttctt gccgagcggt tttccagaca gagacagacc 1128841 ttcattgaat tgtttgatca gcctgattaa atcaaaagat gttaaatcat atacagacgt 1128901 cgccccagga aaatccccga ttttagaagg gtcacctgta atagcaagca cgtcattcag 1128961 ccctaacgta tcaaggccca ttaaatgtga ctgtaagccg ataatgttac ggtcacggca 1129021 cgtaatatgg acaagggaac gcatatcgag ctgctgcttg acaagggcgc cgcaggcaac 1129081 attgctgatc cgcggggtcg ccaaagaatt gtcggcgagt gtcagggcat cgattcccgc 1129141 ttcttttaat tcagcagcag cggacagaaa tttgtcaaag cttagttttt tcggcgggtc 1129201 cagctctacg ataatagagc gttttttcgc tgcgatctca tccaggccgg gctcggttcg 1129261 ctcgtgatga acagaaatga attctttcgc ccgggttttg acttcttttt ccgtaatcgg 1129321 agccagcccg ccaaccgctt ccgccatcgc cctgatgtga ttcggcgttg tgccgcagca 1129381 gccgccgata atccgcgcac cttgcttacg gaattctgac gcgctgtttt gaaaatacgt 1129441 gtcgtctgtt tcatagacga gccgtccctc ttcaagcgaa ggaagactgc tgttcggata 1129501 aacggataag aatacgtcat caaaaatcgg cacttcgctt agcgcttcaa tcatgtgata 1129561 agggccgagg cggcagttaa tgccgacaat atcagctccg agatccgcaa tcgagcgcaa 1129621 tgcgtcagaa agcggcgttc cgtcctgcaa tacgccttgc tcgtgcatgg agacattgag 1129681 cataatcgga agatcagtct ctttgcgcgc gattttcagc acttcacggg cttcttccaa 1129741 atcataatat gtttctaaca gcaagccatc cggctcttca tgcagcagca gatacagctg 1129801 ctcgcggaag ctgcgcttaa tttcgtcaag actgtatgcg tttttattaa atgtgcgtat 1129861 gccgcccatc gttccaagca cgtatgcatc gcctgctgaa gcccgcgcga tctttacggc 1129921 ctcctgattc atttttttga tgtcatcctc aagcccgtgt ctggataatt taatatagtt 1129981 ggctccgtac gtattcgttt gaataatgtt ggctcccgct tcaacgtacg ctttatgtat 1130041 gcgctgaatt tcctccggct ttgaaatatt gagctcctca aaacacctgt caatgccata 1130101 ggagtagagg agcgtcccca tggcgccgtc accgattaac acctgtcttt gcaaatcttc 1130161 taaaagtccc attgtctgcc tcctttattc acatcagcaa ggaaaaaaga gaaataaaaa 1130221 aagtcctctt aagaagaaga ctttgtcagt gattttgtct cttcttatct tccaagctgt 1130281 tcgagcttgc tggatttagc accttggtca tggctgatcg ccattacacc ggttgctgaa 1130341 gcttcgtcgg gccagtccct ctgcttctct tgataagaac ggatatgaaa ttttcgtgtc 1130401 aggaagtgcc aaaagatatc tggcgttttt ccctttctcc aaatttaccg aaaataaaga 1130461 caataatcaa taggaatcag aaaatttatc tgaaatttat aaattgaacg tcaattggca 1130521 gatctgctcc ccgtacagct gagataatct gctgcaggtc atctttgttt tttccggtga 1130581 cacgcacttg atcatcctgc acctgagact ttactttcag tccggagttt ttgatgatcg 1130641 tattgatttt ttttgcgttg tccttgtcaa tgccttgaac aagctttgca cgctggcgca 1130701 ccgttccgcc tgacgcgttt tcaaccttgc cgtaatcaat gttttttgtc ggtacgtttc 1130761 gtttaatcaa tttgctgacc agcacatctt tcagctggct taatttgaat tcgtcatcgg 1130821 aaacgaggac cagctcctct ttatctaaag aaatgtcgct tttgctgcct ttaaagtcat 1130881 atcgggtact gatttccttc agtgcgattt ggattgcgtt ttgcacttca ggcaattcca 1130941 ccttggatac aatatcaaat gaactttctt ttgccatatg aaaacctcca taacatttaa 1131001 cttatgtgtt gattatagta gaataaagag aaacttccaa cagaacaaag aatcaatttg 1131061 tgatgattgg aaaaaatgtt aacaaaatcc gcagagaata agcggaacag gaaggacgat 1131121 agcatgagac cagggcagca attaaccttg agtatagatc accaaaccga cttcggttac 1131181 tttttaaccg atggggaaga tacgattctc ttacataaca gtgaaatgac tgaggatatc 1131241 gaggacagag acgaagtaga agtctttata tacgtagacc agcaggaaag gcttgcggcc 1131301 acgatgaaaa ttccgatcat cagcgcggat gaatatggct gggttgaagt ggtggataaa 1131361 gtggaagata tgggcgtttt cgttgatgtc ggtttatcga aggacgcact agtcgcaact 1131421 gagcatttgc cgccgtacga agatgtctgg ccgcaaaaag gggacaaact ttactgtatg 1131481 ctgaaggtga cgaaccgggg gcgcatgttt gcgaaaccag cgccggaaga tatcatcagc 1131541 gaactgttta ccgacgcttc agaagatctg atgaataaag agctgacagg tacggtgtac 1131601 aggctgatcg catcgggttc attcgtgatc acggatgacg gtatccgctg ttttattcac 1131661 ccgtcagaaa gaaaagagga gccaagactg ggttcaagag tcacaggccg ggtgattcaa 1131721 gtgaaagaag acggttcagt caacttgtcg ctgcttccga gaaaacagga tgcaatgtca 1131781 gttgatgctg agtgcattct aacgtatatg agaatgagaa acggtgccat gccgtacagt 1131841 gacaaaagcc agcctgacga tatcagagaa cgttttaata tgagcaaagc cgcctttaaa 1131901 cgcgcgctgg gccatttgat gaaaaacgga aaagtgtatc aggaaaatgg atggacatac 1131961 gagaaaaaat agcatgaaaa cggctcgcct gcagcagact gcggagcgag ccgttttttt 1132021 atgtctagtt taattcatca accagcgttc tgattgccat ttcgcgatcc acattgtctg 1132081 aaatcgcaat cggcgtaata tcaatggcga gaatgatcag aatcagggca cctgctgcag 1132141 caacataaga aacataatag aaatagttag cggtatcaac agtgttgaca agctcggcct 1132201 gaactctgga tgtatcatcc ttagaagcgg cgatttcctt tgcagcttct actttttctt 1132261 caacgatttg acctgctttt ttcagcagtt catccacttt caatgcatct ttgctgtaaa 1132321 cagctttctt caggttatca aaaaagtcag catcctcttt tttaatatca gcgacaacct 1132381 gattggcaaa agcctttgcc tgttttgtgt tgagtttgtc tgtcatcgct ttattaaaga 1132441 cctctggaag ctgtttgcca acttcccctt gggcaaacac aaagccttta aaaatttcct 1132501 cacctgaata ctcaagctgc tttgcctgtg ccacactttc ttgctgcttc accaaaaaca 1132561 cagtcgtcac caatacaacc gacaaaaata ctagaaacgc cttcttcaaa ctgaaacctc 1132621 tcccttcttg tgttttttat tccacaacag tctgcgaata tatgtaaatt gaatcgtgga 1132681 atcgatagga gtgagataca atatcaaaat gccggccatg ataatcgaaa aactgatgag 1132741 gcccagcatg actgcaaaaa tctcatgcat aaaaacagcg atgatcaaaa tcaatctcca 1132801 atgcttcttc ggcgcaaaca gtgccgcgaa gatgacaatt tgaaccagca gcgtccccca 1132861 tgtcggaatc accacgaacg gacttgttac aattggcttc gttaacgcct gaaaaaagcc 1132921 gttgaagcca atggtttttt cctgggcgaa ataatagacg gccgttccgt ccacccattc 1132981 ctgctgagat agcttagcga cggtagagtg aaaataaagc accgccactt ggattctgat 1133041 cacaaaataa gaaataaaag ctgttatttt tccaagtgtt cttttgccct ctataggtct 1133101 cgtactccaa tgccattttc tcggatcggt cagcgtgatg ggaagcaata aaaaggtcat 1133161 gactgctgct gcctgctcgc ctccgtcgat gacgatcagc gatgactgca ggctgtaact 1133221 gacataccaa tgcagaaccc cggtgattct ggggcgccag ccaatgacaa caagcaccag 1133281 aatggcaatg cagacccatc tgaaaagatt taacatcata tagttatttt cgccgagaca 1133341 aaagagactg agattcattt tacaagctgg atagctgctg atcccgctgg ctggcttcat 1133401 aatgaggctc gggtgattga tgagcagcgt cagcaggctg gatagcgcaa tgatgcttcg 1133461 cgcgaggcca tatacatttg tccacgggtt tctttcgtcc catctggtga tggtctgttt 1133521 tatgttttcg agcatgagat cacaaccttg actatgcttt ttacctgata agacgaaggg 1133581 gtatatttag aatagctcca aggaacaata tcctctttcg tcaaatagta gctgccacaa 1133641 agcagcgggc ggggagcggg tgtttttaat tgcacggttt tggctttgct tttgcatgcg 1133701 ccgaggtcct tttctttaca tgctgtccac tgttccttgc cgacttggct gtagatcacg 1133761 cccatttcaa cgccttgtga ccgcccatac cgatacaggc cgaataggtt gtcagccctc 1133821 atattgggcc atctgacctt ggcgctggca ttttcagcct catataagcc gattgcagta 1133881 tcacgcggat ttttgctaaa aaagccccag ccctgaggga ggatgctgga catgagaaat 1133941 ttggagtcct ttgtcagcgg aatcggggtt gtccctaagc tgccaataat agaaaacaga 1134001 aatagcgaac cccaaaggat tgaaaaaatg acaaaaaatg atatcgattt ctgcattcga 1134061 ctgctccttt taacctgaag aatcgttttt acacttttca taatataaaa acatttatgt 1134121 aataaaaagg ttaaaaagta tgagaaattc catttttgtt aaaaggaaaa acaggacatt 1134181 ttacactgct atatgtgatt gatatatagt gtttttttcg atatatttaa accatgaaaa 1134241 cgaatcaagt taatgaccgc tggattgttc aatttcgaaa agggattttc gagctggcca 1134301 tcctatccct tctgcgttct aaaccgatgt acggttatga gctgacgtca tccttaaaaa 1134361 ccacctcggc gctggctatt tcagagggag cgatttatcc gattttgaaa cgtatgaccg 1134421 agaagggatg gatcgaattt ttttgggaag attcactgga cggcccgaaa agaaagtatt 1134481 acaaaatgac gcaaaaagga gaagaaatgt taaaagaacg gctggagaaa tacctggaaa 1134541 cccatcaagc cttactgtct ttatcggggg atttgctatg aatggacagc ttatcattga 1134601 ccgatacatg gaggaactaa atgcagagct ggcgaatatg cctgatgtag agagagaaaa 1134661 cgctatcgac gaattaaagg ggcatatcac cgctttcgtt caagacagaa tcaaagccgg 1134721 ccttagtgaa gaggaactgc aggaagctgt tgaatctgaa ttttctcatc cgaaggagct 1134781 tgccgaattg atgatgggtg atgggggaga gacgaaaagg aggaggtctt tattgggcaa 1134841 aagctggatt tcggtccttc tcattgtcac gattatcgcc ctgccgctgc tgccgtccga 1134901 cttcagacat ctgccgctgg ctgtttattt aatggtgctc gccggatatg tatggaagcg 1134961 gaaaaaattg gtgatgtttg caggtgtcag aaaaaacaaa atgcgctctc aaaaggagat 1135021 tgtcaagatt tcgcgagtcg gtgcggttta tctgctgttt ttagcagtgg tgctcctttt 1135081 gagcccgttc ctcaatgcgc ttgtcgtcct gctgctgatt gcagtaagct gcgccgcttt 1135141 ttttcttttt cttaacatca agtaatcttg taggaggctg taagatggaa atcagcatca 1135201 attatctatt aattgtcatc gcgcttttat tctttgtggt tgcctatttt gtcggaatca 1135261 aaaaacaaac ctggatgttg gctgggttta acgaggcgcg tatacgggat aaagatcggc 1135321 tggccagaat agcaggctac tttttcttga attccggttt gttcattttg ctgaatagtt 1135381 ttatctcatt tcaaggtcag gagcagctca tacctccgct tatactggca tatggagcag 1135441 gggttattat ttatgtcaat aaaaaattag tagagtagaa aaagaagggc agagcgaaat 1135501 atctctgccc ttcttttttg ggaaaataag aacgaagcac cacatacaag tttttgtatt 1135561 tttgatagga tgaagaaaaa tggtagattc caaaatagga aggatgtggt gttttgcgca 1135621 acttgaccaa gacatctcta ttactggccg gcttatgcac agcggcccaa atggtttttg 1135681 taacacatgc ctcagctgaa gaaagcatcg aatacgacca tacgtatcaa accccttcat 1135741 acatcatcga aaagtcaccg cagaagccgg tacaaaacac aacccagaaa gaatcgctat 1135801 tttcctatct tgacaagcat caaacgcagt ttaagctcaa agggaatgcg aacagccatt 1135861 ttcgcgtttc gaaaaccata aaggatccaa agacaaaaca aacgtttttt aaattaacgg 1135921 aggtttacaa aggaattccg atttacggct ttgaacaagc ggtcgcgatg aaggaaaaca 1135981 aacaagtgaa aagtttcttt ggaaaggtgc atccgcaaat caaggacgtc tccgtcacac 1136041 cgtctatttc tgagaaaaaa gcaatacata cagcaaggcg tgagctcgag gcttccattg 1136101 gaaaaatcga atatcttgat ggggaaccaa aaggcgaatt atatatctat ccacacgacg 1136161 gtgaatatga tctcgcctac cttgtgagac tctcgacatc tgaacctgag cctggctatt 1136221 ggcattattt catcgatgcc aaaaacggaa aggtcatcga gtcctttaat gccattcatg 1136281 aagcggcagg tacaggaatc ggcgtgtcag gtgatgaaaa aagctttgac gtcacagaac 1136341 aaaatgggcg cttttatttg gctgacgaaa caaggggaaa agggatcaat acatttgacg 1136401 cgaagaacct gaacgaaacc ttgtttacgc ttttgtctca actgatcggg tatacgggca 1136461 aagaaatagt cagcggcacg tccgtattta atgaacctgc ggctgtagac gcacacgcaa 1136521 atgcgcaagc cgtttacgat tattacagca agacatttgg ccgtgattct tttgatcaaa 1136581 acggagcaag gattacgtct accgtgcatg tcggcaaaca atggaacaat gctgcgtgga 1136641 acggtgtcca gatggtatac ggggatggag acggttcgaa atttaagccg ctgtctggat 1136701 cgctcgacat tgtcgcgcat gaaatcacac acgcagtcac acagtattcc gccggtcttt 1136761 tatatcaagg agaacccggt gcattaaatg agtccatttc tgacattatg ggcgcgatgg 1136821 ctgaccgtga tgattgggag atcggcgaag atgtctatac tcctggtatt gcaggagatt 1136881 cattgcggtc attggaggac ccatctaagc agggaaatcc agatcattac tcgaaccgct 1136941 acacaggaac agaggattat ggcggagtcc atatcaattc gtccattcac aataaagcag 1137001 cttatcttct tgcagaagga ggcgtgcacc acggtgtaca ggttgaaggg attgggcgtg 1137061 aagcaagtga acaaatttac tatcgggctt taacatatta tgtaacggca tctacagatt 1137121 tcagcatgat gaagcaagcg gcgattgaag ctgccaatga tttatacggt gaaggctcga 1137181 agcaatcagc ttcagtcgaa aaggcgtatg aggctgtcgg cattctatga gcaaacaaaa 1137241 acagtcagga cacagagtct gactgttttt gtttgctcat tttcttaaaa agaatatcgc 1137301 caatgtacct ggaccggcat gcgagccgat ggctgaactg attggatgca taatgatttc 1137361 tttcggcttg aacgcttcct caatcaggtg tttcatatcc gtggcttttt ctttgttcgc 1137421 ggcgtagcta atcccgacgg tttgattgct ccaatcatcc ccgcgctctt tcataagctc 1137481 gatgatccgt ttgaaaagtt tcttctgtcc gcgaattttt tccagaggca caagcttgcc 1137541 gtcctccatc tgaagcagcg gtttaatatt caacaggccg ccgacaaaag cggacgtttt 1137601 ggatatccgg ccgcccctcg cgagatatgt taaatcatca acggtaaaaa tgtgttcaag 1137661 ctggctgcaa aagttcttta cagacgtttc aatttcttgt attgtattcc cgttgataca 1137721 gagatcggca gcatgccgga cagccagacc gtatcctaat gaagcgcatt tggaatcaat 1137781 gacccgcaaa tcgaaatcgg ggaattcctc cttcacttca ttggcgatca ttacagctgt 1137841 ctgatacgtg ccggagagac ctgaggaaaa ggcaatgtaa agagcgggat cacctgtttc 1137901 ggcatattgc aaaaacacat ttttaatcgt ttgcggtgag gcttgggacg tcttaggcgt 1137961 ttctccattt tgcatcgctt caaatatttg atccgcatga attgtgactg catcttcgaa 1138021 ttctttatcg ccgagagaaa ccctgagcgg aataaagcca atgccttttt cttcaaaata 1138081 agaacgaggc aaatcagtgg cgctgtcagc gatgagatga actgtcatat tgcttccctt 1138141 ctttccgtta tcgctcgtta tcatgagagt taagccaact atatcatatt aatttgccaa 1138201 aatcgtgttc aaatatttgt tttaagggaa aacataataa agaagaaaga gcggaggaac 1138261 atgccatggt actagatcaa acaaaaaaat tactcatcgt catcatcggc gctttactca 1138321 atgctgccgg gctgaactta tttttgatac ctgcagatgt atatgccagc ggatttacag 1138381 gtgttgccca gcttttatca agcgtcgttg atcaatatgc ccccttttac atatcgacgg 1138441 gaacgctctt gttcctctta aacattccgg tcggtatttt aggatggctg aaggtcggca 1138501 aatcgtttac agtgtacagc attttaagtg tcgcactcac tactctgttt atggggatcc 1138561 tgccggaaac aagcctgtca catgacattt tgctgaacgc ggtgttcggc ggcgtcattt 1138621 ccgcagtcgg tatcggctta acattaaaat acggagcttc gacaggcggg cttgatatcg 1138681 tcgccatggt acttgcaaag tggaaggata aacccgtcgg cacgtatttc ttcattctga 1138741 acgggattat catcttgacg gcaggattat tgcaaggttg ggagaaagca ttatataccc 1138801 tggttacact atatgtgaca acgagggtga tcgacgccat tcacactcgc cacatgaagc 1138861 ttacggcaat gattgtgacg aaaaaagcgg acgaaatcaa ggaagccatt tacggaaaaa 1138921 tggtgcgcgg catcacaact gttccggcaa aaggagcatt tacgaacgaa cagaaagaaa 1138981 tgatgattat cgtcatcacg aggtatgaac tgtacgattt agaaaagatc gtcaaagaag 1139041 ttgatccaaa agcatttacg aacatcgttc aaacgacagg gatttttggt ttctttagaa 1139101 aagactgacg aaagcaggtg gaagtcgtga aacggctgct tgtgatgctc ctccccgtgc 1139161 tgcttttgat aggctgcggg aaagatgagc agacagaacc cgataaggag gtatcaggcg 1139221 gaatggagaa tcaagaggtt gttttatcta ttgacgcaat tcaggagcct gaacaaatca 1139281 agtttaacat gtcgctgaag aaccaaagcg aacgtgctat tgagtttcaa ttcagcacag 1139341 ggcaaaaatt tgaacttgtc gtgtatgatt ctgagcacaa agaaagatac cgttattcga 1139401 aagaaaaaat gtttacgcag gcttttcaaa acctgacgct tgaatctgga gaaacatatg 1139461 atttctctga tgtgtggaag gaagtccctg agcccggaac ctatgaggta aaggtgacat 1139521 ttaagggcag ggcggaaaat ctcaagcagg ttcaggctgt tcagcagttt gaagtcaaat 1139581 aagaggctat ggcgagtcgc catagccttt ttttattgca gtttgtccag ctgattttga 1139641 aattgatgca actgttgacg ttccgcatct gtcgaattgg catacgcaga agatacagca 1139701 tttttggctc tcagaatcgc ttgctcctga tcgccttcct caaagccgtt tgtcaccatg 1139761 accgcctgtt gaacaaatga ttttgcctgc tgaaacagtt catttctcat ttaatattca 1139821 tactgccttt cagccgagtc tcgtgccgcg gcatgctggt gagcttcttc taaagtagac 1139881 cgatatggaa atcttgcggc gtgtagcccg atggagtctt taccctgctg aataaacctt 1139941 ctggatttgc ttcgtttacc cattttgaga ctgccccctt ccatactttg acgagatgag 1140001 tcgtcttcaa tagtatggtg gggtaaagta aggtttatga gtgggaaaaa ttaatacgga 1140061 ccttctttaa agtgagaaat attctttcaa aaaccttgcc acgccgtcct cttcatttgt 1140121 ggccgtagtt cggttggcaa tctgcttgac cgcgtcaatt ccatttccca ttgcaacgcc 1140181 gcagcctgca aattcaagca tttccaaatc gttatcctca tctccaaaag caatgatccg 1140241 ctccctcggc acgccgtaat aatcgctgat tttctgcagg ccgaccgctt tattcatgcc 1140301 gcttttgata atttcaatga catgccaagg agcggcccat cttctatggt cgatcacctc 1140361 ggcatgcaca tccgataaat atgagcgtat tgccggcaca tcctcttcct ttgcatgtat 1140421 gagtacggac gtcacatctt caccgagatt ttcccgcaag tctccgaccg ttacatttgt 1140481 tgtgttcatg ttaaaggcat ctatcaggtg ctcatcatgg taatgaaagt atacgtcgtc 1140541 aatcacttca gcaagcacgt tatgtacgtt gtagctctcg ctgatatcca cgagctgttt 1140601 gacaacatca agcggcagtg acgtatgata ccgtccccag ctgtcgtctt gcggatgatg 1140661 gacaaatgct ccgttaaaat tgacaattgg cgttgtcagc tccatctgct ggtagtacat 1140721 ggaacttgaa cgatacggac ggcctgttga gatgcagaca taatgcccgt catcttttag 1140781 gcgctgtatc gtatgaaggg tgttttcaga tatggtttta tcatccttta ataatgttcc 1140841 atctaaatct aatgcgatta aatagggttt tgtctccatg aaaagctcct ttaaccttag 1140901 attttgcttg ttttgcctta cttacagtgt agctttttac catctttatt gtctacatgt 1140961 tacacttatg attatggtta tcctaaggag gggcacattg tgatacaaat tgagaatcaa 1141021 accgtttccg gtattccgtt tttacatatt gtaaaggaag agaacaggca ccgcgctgtt 1141081 cctctcgtga tctttataca tggttttaca agcgcgaagg aacacaacct tcatattgct 1141141 tatctgcttg cggagaaggg ttttagagcc gttctgccgg aggctttgca ccatggggaa 1141201 cggggagaag aaatggctgt tgaagagctg gcggggcatt tttgggatat cgtcctcaac 1141261 gagattgaag agatcggcgt acttaaaaac cattttgaaa aagagggcct gatagacggc 1141321 ggccgcatcg gtctcgcagg cacgtcaatg ggcggcatca caacgcttgg cgctttgact 1141381 gcatatgatt ggataaaagc cggcgtcagc ctgatgggaa gcccgaatta cgtggagctg 1141441 tttcagcagc agattgacca tattcaatct cagggcattg aaatcgatgt gccggaagag 1141501 aaggtacagc agctgatgaa acgtctcgag ttgcgggatc tcagccttca gccggagaaa 1141561 ctgcaacagc gcccgctttt attttggcac ggcgcaaaag ataaagttgt gccttacgcg 1141621 ccgacccgga aattttatga cacgattaaa tcccattaca gcgagcagcc ggaacgcctg 1141681 caatttatcg gagatgaaaa cgctgaccat aaagtcccgc gggcagctgt gttaaaaacg 1141741 attgaatggt ttgaaacgta cttataaagc actaagttat taacaagagc tgaatttacg 1141801 ttatactgta gaaaaaagga gtgagggaac gtggaagaag cattaaaaga aaacatcatg 1141861 ggcgccctgg aacaggttgt cgatcctgag cttggcgttg atatcgtgaa cctcggcttg 1141921 gtatatgacg ttgatatgga tgaagatggc ttgacgcaca tcaccatgac gctaacatca 1141981 atgggatgcc ctttagcgcc gattatcgtg gatgaggtga aaaaagcatt agcggacctt 1142041 cctgaagtga aagacacaga ggttcacatt gtatggaatc cgccttggac tagggataaa 1142101 atgtccagat acgcaaaaat tgcgcttggc attcaataaa acaaaaaagg acagcctgac 1142161 atgtgaggct gtcctttttt acagctgaaa ggagtgaaag gaaatgatgt acctgctggc 1142221 agttttatgc ccgccgcttg ctgttttgtt ttcgggaaaa ccgtttcagg ccttgctgaa 1142281 tctcatattg acctgtatct tttggctgcc gggcgcgatt cacgcctgct ttatcgtcgc 1142341 cgaccgccgt gccgaaaaac gggcaagaag ataatttgga aaaatgagga cgcagtcatg 1142401 gtataatggt cataaaaaca gcagggagag cactatgaaa aagaaattgc ttgcattcgc 1142461 gctttgtact ggcgcgtatg cggccctgtt tgcgtactct gtgaactcag agcaaaaaac 1142521 agccacaagc gagatgacgg atgtcagccg cctgatgcct gtaaaaataa agcagacagt 1142581 gaaagggcag gaagaggaaa tgctcattga cacagtcaaa gaggcaaatc gaaaaaacat 1142641 aaaaatttca atcgccgggg cccagcactc catgggcggc catacatatt atgaggacgg 1142701 catcgttctc gacatgacgg gctacaacaa aatcctgtca ctcgatcaag agaagaaaac 1142761 catcagggtg caaagcggtg caacgtggaa tgatatccag aaatacgtga atccatacgg 1142821 actcgcggta aaagtcatgc agtcacaaaa catttttaca atcggcggat ctctcagcgc 1142881 aaatgcacac ggacgtgata ttcgctacgg ctcgctaatt gatacagtca aatcattccg 1142941 gcttttaaaa gctgacggga tgattatcac tgtcactcca aaagatgatt tgtttacggc 1143001 ggtcatcgga gggtacggcc tttttggcgt gattcttgat gtaacgcttg agctgacaga 1143061 tgatgagctg tatgtcatga agacagaaaa aatgaattac agcacatact cagactattt 1143121 ttcaaagcat gtaaaaggaa atccagatgt ccgaatgcat ctggcgcgaa tttcaacagc 1143181 gaaaaaagga tttctgaaag acatgtatgt cacgaattac gtattggcta atcatcagga 1143241 tcagctgtcc tcatacagcg aacttaaaga agacgagtat acgggagcca caaagtttgc 1143301 actcggcttg tcaagacggt atgaatgggg gaggaattgg ctgtgggaca cacagcaatc 1143361 ctatttcctg agccagaacg gcacagagat ttcacgcaat aacgtcatgc ggtccgaatc 1143421 aaagtttctt gagtatgaaa acaatgacaa cacagatgtt ttgcaagaat actttgtgcc 1143481 cgtgaaggag tatgggtcct atattgatga cctgagacaa acgctgtcgg acgaagatct 1143541 gaacctgctg aacattacga tccgctacgt gcagaaaaat gaaaaggccg acctttccta 1143601 tgcgaaggac gatatgtttt cgctcgtact attaataaac gagggctttt caaaagaaga 1143661 ccaggcagat accgcccgaa tcatcaggcg catgacagac gttgccatca agcacggcgg 1143721 cagctattat ctgccttata tgacctacca gacaaaagcg caaatgagac aggcatatcc 1143781 gaaaagtgaa gcgttttttc agaaaaaacg aacctatgac ccggatgagc gctttatgaa 1143841 ttacttttat cagaggtata aataatgggg aaaaacaaat taaaatggct gacattatca 1143901 caaagcagcg tgtttttcgc aagcagctta atctttccgt tttatattct gtttgtgaaa 1143961 aatatcggct caagctacac acagttcggt ttttcctacg gattgttcgg gttgagcgga 1144021 gcgcttattt acccgctcct cggacggctg tctgaaaggt ttgacagccg ttattttctg 1144081 cttctgaact cgtgggggat ggctgttctg cttttatatg tcccgcatat cggaagcgtc 1144141 gttcaagtgt atatcgtcca agtgctgtta gggctctttg gagcgatgca aaagcatgga 1144201 gaaaaagtgc tgatcgctaa ttttacagac agtggagagc gtggaaagaa gatcgggaat 1144261 taccattttt ggacagctgt cttttcagca gcagccatta tgctcggggg ctttctcgct 1144321 gactttttca cagtgcaaat gattttttat gcaagctcta ttctatattt tttgagtgga 1144381 ttgatgatga tgaaaacagg ctgacgcggt cagcctgttt ttttatgcgg ctgaaatgcg 1144441 gcaccgcatc aacgtttttg tgctggagtc gtgctgattt tttttgagcg gaattcccat 1144501 tgaacagaaa atttataaat gaataaaaat attaaatata cgattgaatt aatttttatt 1144561 catgttataa tgttaaataa tttcacaaag accaagaggg tgaacttgtt ttgaaaatag 1144621 gaattgtagg tgctacagga tatggaggca ccgaacttgt caggattctt tcgcatcatc 1144681 ctcatgcaga ggaatgcata ctttattcat ccagcggaga agggaatgtc tatagcgagg 1144741 gttatcctca tcttaccggc ttagcggatc agcagctgaa gccgattgat atgaatacga 1144801 tcaaacacga aatagatatc atgtttctcg ctgcgccgcc cggagtatca agtgaattga 1144861 ctccaaagct ggcagacgcg ggaattacgg ttattgatct gtcaggtgat ctgaggataa 1144921 aagaaccggc tgaatatgaa aaatggtata aacggacagc ggcaccgaag gcggtgattc 1144981 aagaggcggt atacggtctg gcagaactga atcaactgca aattcaacag gcgaaactca 1145041 ttgccaatcc aggctgtttt ccaacagctg ttttgcttgg cctcgcgcca ttggctcaaa 1145101 agaaactgct cgatgaatct ttcgttatcg ttgacgcgaa gaccggtgtt tccggagcgg 1145161 gaagaaaagc atccatggga actcattttt ctgagctgaa cgacaatttt aaaatttata 1145221 aagtcaatga acatcagcac acgccggaaa ttgagcaggc gctgaatgaa tggcagccag 1145281 gtctcgggcc cattacattt tcggctcact tggttccgat gacaaggggc atcatggcga 1145341 cgatgtatac cagattaacc tgtgacctaa ccgcagatga cctgcatgat ttatattcgg 1145401 aattttacca agattcatat tttgtgagag tgaggccaaa aggtcagtac ccgcaaacga 1145461 aagaagtgta cggcagcaat ttctgtgata tcgccgtgac cctcgatgag agaacgaaca 1145521 gagtcacgat cgtctcggta atcgataatt taatgaaggg tgccgccggt caggcagtgc 1145581 aaaactttaa tttgatgaat ggctggaatg aagaaactgg actcaccatc acgccaattt 1145641 atccatagaa cgggagagaa tcgaaccatg attcagttaa gtgaagatca aattgtaaaa 1145701 gtaacaggtg atgtatcctc gccaaaaggg tttcaggcaa agggtgtgca ttgcggactg 1145761 cgctactcga aaaaagacct cggcgtcatt atcagcgaga caccggccgt gagtgcagca 1145821 gtttataccc aaagccactt tcaggctgct ccgatcaaag tgacacaaga cagcttaaag 1145881 cacggaccga cactgaaagc cgtcatcgtc aacagcgcca ttgccaacgc ctgcacggga 1145941 gaacagggct taaaggacgc atacacaatg cgggagagct ttgcttcaca gcttggcatt 1146001 gagccggagc ttgtcgctgt ttcatcaacg ggtgtcatcg gcgagcattt agacatggaa 1146061 aaaatccacg cggggatcga actgctgaaa gaaacacctg cgggatcagg cgattttgag 1146121 gaagcgattt taacaactga tacggtgatc aagcagacgt gctatgaact ggcaatcggc 1146181 ggcaaaacag tcacgatcgg cggagcggcc aaaggctctg ggatgataca cccgaacatg 1146241 gccacgatgc tgggatttgt gacaactgac gcggcaatcg aagaaaaagc gctgcaaaag 1146301 gcgcttcggg aaatcactga cgtttcattt aaccaaatca cagttgacgg agaaacatcc 1146361 acgaacgaca tggtattagt tatggcgaat ggctgcgccg aaaacgagtg cctgacagaa 1146421 gaccatccag actggccggt ctttaaaaaa gcgctcttgc tcacttgtga ggatctagct 1146481 aaagagattg ccagagacgg agaaggcgcg acaaaactaa ttgaagccca agtacaggga 1146541 gcgaaaaaca atcttgatgc aaacgtcatt gccaaaaaga ttgtcggctc aaatcttgta 1146601 aaaacggcag tatacggaac agatgccaac tgggggcgga tcatcggagc catcggacac 1146661 tccgcagcac aggtgacggc agaagaagta gaggtttatc ttggcggcca atgcctgttt 1146721 aagaataacg aacctcagcc attctctgaa tctatcgcca aggaatacct tgaaggagat 1146781 gaaatcacca ttgtcatcaa gatggctgaa ggggacggaa acgggagagc gtggggctgt 1146841 gacctgacct atgactatat caaaattaac gcgagctatc gcacgtaata aaggggagcg 1146901 aaatgaagaa aacaatcgtt tttaaatgcg ggggaagcgt catccgtgag ctgtcggagg 1146961 aattttatca aaatctgaaa gagctgaggg cgtcaggctg gaagctggca atcgtacatg 1147021 gcgggggacc ggaaatcaca aatatgctga aacggttaaa tatcaagaca gagttttcgg 1147081 gcggacagag gaaaacaacg aagccggtgc tggaagtggc ggaaatggtt ttatccggtt 1147141 ctgtcaataa atttttcgtt gctgagcttg ccaaacacgg actgcgagcc gcgggcattt 1147201 ctggtaagga tggcggtctt ttggaggctg attatctaga tccggaaaca tacggagaag 1147261 tgggagaaat caaaaaagtc gatgcgtcca tggtgaacgc gctgatggaa aatggcatca 1147321 tccccgttat tgcgccgctg tctatgacaa gcgactgcaa aacgctgaat gtaaatgctg 1147381 atctggctgc ttcagcagtc gccggagcgc ttgaagccga taagctgatg ttcgtcacgg 1147441 atgtcgatgg aatcatgaag gaaaagcagc gtctggacgt cctgacccct aaggagattc 1147501 agatgctgat caagcaggaa gtgatcacag gagggatgat cccgaaggtc aattcagcct 1147561 tgtcagcttt atcagatcag gtgtctgaag tcatgatcgt aaacggtaaa ggatcattct 1147621 tcgcagaaca aacctttcaa gggacaaaaa ttgtcaaagc aaaggaggct gtttcatgag 1147681 cagcttgttt caaacctacg gccgttggga tattgacatc aaaaaagcaa agggaacgta 1147741 cgttgaggat caaaacggca aaacgtacct tgatttcatt caggggattg cggtatcaaa 1147801 tctaggacac tgccatgaag cggtgacaga ggcagtcaaa aaacagcttg acagcgtatg 1147861 gcacgtatcc aacctgtttc aaaacagtct ccaagagcaa gcggcgcaga agctggcagc 1147921 gcatagtgcg ggagatcttg tctttttctg caacagcggc gcggaggcga atgaaggtgc 1147981 gataaagctt gccagaaaag caactggaaa aacaaaaatc atcacttttc ttcagtcgtt 1148041 ccatggccgc acgtatgcag ggatggctgc gaccggacag gataaaatca aaacaggctt 1148101 cggcccgatg cttggaggct ttcactacct gccatacaat gatccttctg cttttaaagc 1148161 tcttggggag gaaggcgata ttgccgcggt gatgcttgaa acagtgcagg gagaaggagg 1148221 agtcaatccg gcgagtgctg aatttttatc agccgtacag tcgttttgca aggaaaagca 1148281 agcccttctc attattgatg aaatccagac cggcatcgga cggacgggaa aaggcttcgc 1148341 atatgagcac ttcggactct caccggatat catcacagtc gccaaaggat tgggaaacgg 1148401 ctttccggtc ggcgctgtca tcggaaagaa acagcttgga gaagcgttta cccctggttc 1148461 tcacggaacg actttcggag gaaacatgct ggcgatggct gctgtgaatg ccacattgca 1148521 aattgtattc cagcctgact ttttgcaaga ggctgctgac aaaggggcgt ttttaaaaga 1148581 acagcttgag gcagagctaa agagcccttt tgttaaacaa atccgaggta aaggattaat 1148641 gcttggaatt gagtgtgatg gcccggttgc tgacattatt gctgaattgc agacattagg 1148701 cttgcttgta ttgccggccg gcccgaacgt gattcggctg ctgccgccgc tcaccgtgac 1148761 taaggatgaa atagcagaag ccgtcagcaa gctgaaacag gcaatcgctc atcattccgc 1148821 tgtaaaccag tgattttttt tcgatataaa ggcataaaaa ttcattttta taattaatta 1148881 ttcatcaaga ggtgggctgt tagatggaag gttatttagt gttagaagat gggacatcgt 1148941 tcagcggcga gctggacggt catgaaaact gcacgggaga agctgttttt ttcacaggaa 1149001 tgacaggcta ccaggaagtg ctgacagatc catcatataa gggacagatt attgtattta 1149061 cctacccgct gattggcaac tacggcataa atgaaaagga ttttgaaagc aagaaaccgc 1149121 aagtaaaagc cgcggttgtc tatgaggcgt gtgatcactt ttctcattat gaagcggtat 1149181 acagcctcaa ggagtatcta cagaaatgga atattccgct gttaacccat gttgatacga 1149241 gggctgtcgt gaagaaaatc cgggcaaacg ggacgatggg tgcgacagtc acagcctcta 1149301 aagaaggagc tgagattgcc cttcaaccag agaatgtggc agagcaggct tccgcccagg 1149361 aaatcagcac attcggcgac gggaataaac atatcgctct cattgatttt ggctataaaa 1149421 agtcaatcgc atcatcactt gtcaaacgag gctgcaaggt taccgtggtg ccataccagc 1149481 aaatggaggc cgtatacaac atcaaacccg atgggctatc gaacggacct ggagatccga 1149541 aagccattca gccatattta ggaaagatca aaagcatcat cagccgcttt ccgactctag 1149601 gcatttgtct cggacatcag ctgatcgcgc tcgcgtttgg agggaatact tttaagctgc 1149661 cattcgggca caggggagct aatcatccgg tcatcgaccg taagacgaaa cgggtcttta 1149721 tgacaagcca aaaccacagc tatgtggttg atgaacagtc gattaatgaa gaagagctca 1149781 ccatcaggtt tcatcatgtc aatgatacgt cagttgaagg gcttgcccat aaaaaactgc 1149841 ctgtcatgag tgttcaattc cacccggaag cccatcccgg acctgcggaa agcgaatgga 1149901 tttttgatga ttatctaaag aatgtgatac cagcaaggag agaaatcgcg catgcctaaa 1149961 gacaccagta tttcaagcat attagtaatt ggctcaggcc cgatcatcat cgggcaggcg 1150021 gcagaatttg attattcagg cactcaaggg tgcatcgcgc tgaaggagga gggctaccgg 1150081 gtaattctcg tcaacagcaa tccggcgaca attatgactg atgaagcctt cgctgatgaa 1150141 atttattttg agcctctgac agcagaaagc ctgacagcca tcattaagaa agaacggcct 1150201 gatgggcttc ttgccaattt aggcggtcag accgcgttga atttagcggt ggagcttgaa 1150261 gaaacgggtg ttttaaaaga gcacggcgtc aaactcctcg gcacatccgt tgaaacgata 1150321 caaaaaggag aggaccggga aaaattccgt tcgttaatga atgaattaaa acagcctgtg 1150381 ccggagagtg aaattgttga taacgaggcc gatgccctcc attttgcgga atccatcggt 1150441 tttcctgtta ttatcagacc agcttacaca ttaggcggaa agggcggagg aatcgcccct 1150501 gataaagaag cctttacagc tatgattaag caggcgctat tagcaagccc gatcaatcaa 1150561 tgccttgtcg aaaaaagcat tgccggcttt aaagaaattg aatatgaagt catgcgtgac 1150621 agcaataaca catgcattac cgtctgcaat atggaaaata tcgatccggt cggcgtgcat 1150681 acaggtgact ctatcgttgt ggcgccgtca caaacattga cagacgaaga ctatcaaatg 1150741 ctgcggacag caagtctgac gatcatctca gcacttgatg ttgtaggcgg ctgcaacatt 1150801 caattcgcgc ttgatccatt cagcaagcaa tattacgtca ttgaagtgaa tccgcgtgta 1150861 agccggtcat cggctctcgc atctaaagcg accggttatc cgattgcgaa gatggccgcg 1150921 aaactggcag tcggatacac tcttgacgag ctgaaaaatc cgctcacagg ctcgacttac 1150981 gcaagctttg aaccggcact ggattatgtg atcgtcaaat ttccgcgctg gccgtttgat 1151041 aaattcaaaa acgcagaccg caagcttggc acaaaaatga aagccaccgg tgaagtgatg 1151101 gcgattgaac ggaatttaga agcggcgata caaaaggcag ccgcgtcgct tgaattaaaa 1151161 aatatcggga cacaccttcc agagctcagc gggttgtcaa ttgatacgct atgggatttg 1151221 gcaatcactc cggatgaccg cagatttttc gttgtcatgg agctgttgag ccgcagcgtc 1151281 tcgattgatg acatccatga aaaaacaaaa attgatccgt ttttccttca tacctttgac 1151341 aacatcatca aattggaaaa ccgcctgatg gaagcaggga gcgatctctc ttttgaatta 1151401 ttgaagaaag caaaggaaaa gggattctca gacgcaacga ttgcctcgct gatcagcaaa 1151461 acagaagaag aggtgcgcgc gcttcgcaag gagatgggca ttacgccttc ctttaaaatc 1151521 gtagatacat gcgcggcaga gtttgatgcg aaaacaaact atttttactc cacatatttc 1151581 ggagagaccg atggagacat cagccgcaaa gagaaaaaac gcgcgctcat tatcggatca 1151641 ggcccgattc ggatcggcca aggcgttgaa tttgattaca gtgctgttca cggtgtgctg 1151701 acactgcaag agcttgggtt cgaaaccatc atgattaaca ataacccgga aactgtcagc 1151761 accgattatg aaattgcgga ccgcctgtat tttgaaccga tgacaacgga gcatattgta 1151821 aacgtggcgg agcaggaaaa tattgatttt gcaattgtgc aatttggcgg tcaaactgca 1151881 atcaatgctg ctgaagcgct cgaaaaagcc ggcattactc ttcttggcac atcatttcaa 1151941 acgctcgacg tgttagagga tcgggatcaa ttttatcagc ttcttgacga gctgggattg 1152001 aagcacgcaa aaggagaaat tgcttataca aaagaagaag ccgcttcaaa agcgagtgag 1152061 atcggctatc cggtgttaat ccgcccatct tacgttatcg gcggaatggg catgatcatt 1152121 gttgactcgc aagcccagct ttctcagctg ctgaatgatg aggacagcat gccatacccg 1152181 attttaattg atcagtatgt gtctggaaag gaagtcgaaa ttgatttgat ttccgacggc 1152241 gaggaagtct ttatcccgac atataccgag catattgaac gggcaggtgt ccattcaggg 1152301 gacagttttg ccattcttcc cggaccgtcc atcacgagcg ggctgcagca gggcatgaaa 1152361 gatgcggcac aaaaaattgc ccgaaaactt tcatttaaag gcatcatgaa cattcaattt 1152421 gtgatcgaca atggaaacat actcgttctt gaagtgaatc cgagagcgag ccgcacggtt 1152481 cctgtcgtca gcaaagtaat gggcgttccg atgattccgc tcgccacacg tctgctggcg 1152541 ggagcgtcct taaaagatct aaatccggca gttcaaaatc atcatggagt tgccgtgaag 1152601 ttccctgttt tttcttctca tgcgatccag gatgtggatg tcaagcttgg accggaaatg 1152661 aaatcaacgg gagaaggcat gtgtgtcgca tatgattcta acagcgcctt gaaaaaaatc 1152721 tatacaagag tctggagtca aaaaggaagc atttatttgc aaaacgttcc ggaagatgtg 1152781 aaggagttag cagaaaacgc aggttttaca atacatgaag gaacatttgc ctcatggatg 1152841 gaacaggaag gaaactcgct ccacattaat ctgagcggtt ctgaagaagc acgcaaagaa 1152901 cgtttggaag ccatgacgca cggcatcccc gtctttacag aagaagaaac tgtgcgggcg 1152961 tttttacaaa gcggttcagg ccatccgcag cctgtatctc tcaaagacct ctataaaaag 1153021 gaagtggcat catgcacaca gtgacgcaaa ccagtttata cggaaaagat ttattaacgt 1153081 taaaggacct tagtgaagaa gatataaacg ccttgctcgc agaagccggt gagctgaaac 1153141 aaaacaaaat tcagcctata ttccatggca aaaccttggc gatgattttt gaaaaatcat 1153201 caacgcggac ccgtgtttca tttgaagcgg gcatggcgca gctgggcggg agcgccctct 1153261 ttctaagcca gaaagatctg cagctggggc gcggtgagac tgtcgctgat acggcaaaag 1153321 tgctgtcagg ctatgtggat gccatcatga tccggacctt tgaacatgaa aaggtggagg 1153381 aacttgccaa agaagctgac attccggtga tcaatggact taccgataaa taccacccat 1153441 gccaggcgct ggcggatctc ttgacgatta aggagataaa agggaagctt aaaggcgtaa 1153501 aagtcgcgta catcggtgac ggaaataacg tggcgcactc cttgatgatc ggctgcgcga 1153561 aaatgggctg tgatatctcg atcgcttcac caaagggata tgaagtgtta gatgaagcag 1153621 ctgaagcggc aaagacatat gcacttcaat ccggctcttc tgtcacgctg acagatgatc 1153681 cgattgaagc tgtaaaagac gcggacgtga tttattctga tgtgtttaca agcatggggc 1153741 aggaagcgga agagcaagaa cgtcttgctg tctttgcgcc ttatcaggtg aatgcggcgc 1153801 tggtcagcca tgccaagcct gactatacat ttttacattg tctccctgcg catcgcgagg 1153861 aagaagtgac tgcggagatt attgacgggc cgaactctgc agtgttccag caggcggaaa 1153921 accgtcttca tgtgcaaaaa gcactgctga aggccatttt atataaaggg gaatcatcaa 1153981 aaaactgctg agccaaactc agcagttttt ttgatggcaa catattcaca gccgcttagg 1154041 cgcatactac agcaaaaagg aaaaggagga aaaacagtgg gacagcagca ccaattccgg 1154101 cccggacaga aagcgcctaa taacggtgtc tacgtagaaa tcggcgagac agggagcatg 1154161 gttaaaaacc ctcaaaaggt ccatctgtca gcaggggaaa tgttccccga aacatcaaac 1154221 cacaaccggc tgtggaccta caaaagaaag ccgtgaccac taaaaaaccc aaaacaataa 1154281 atgttttggg tttttggctt tttaatgctg gcttgcattt ttgttcatag gcatgatttc 1154341 tgctaaaacc atgattaaga catacagtac aacagcaatg acagatgatg ttttgaaatt 1154401 atacgtaacg ctgttcatgc ttgcaaccaa gtagcatgcc atatgtgata aaaggaacgt 1154461 ccaaataaag gcaataatat atcgcacgtt tccacctcgt ccttctcatt ctattctaaa 1154521 agttatcata ccatacaaaa agcgaagggg gaatccaatt ttagcagaaa gtgaggtgac 1154581 aaaagagtct gattcgtcac actttaatgg taaaatataa aacgtcaatc agtataatag 1154641 ccaaaaatgt aaaaggctag gactttacct tattcgtttc ttttctattt acataagata 1154701 gcgtgagatg aagtgtgaaa ggaggcgggc aagcgatggg aataacggaa agatactttc 1154761 aactgggaac ggagcataat gtcattcatc tgccctatcg cccgaacggc ttcggcatct 1154821 ttatcttggg ggacagaacc cactttgtcg gacatgattc aagcttttgg cagcagcatt 1154881 atggcagaaa tcagcttctg agcatgttga tgaatgaagg atacactctt tttaacagca 1154941 atctgttcgg aaggcattgg ggggcggaaa aagcagtcac ctatgccaaa cagctgatac 1155001 attctgtgct gaagcaggaa atcctcaatc cgaagattca tattttagca gaaggcatgg 1155061 gtgctctcgt ggccgatgaa ctgcttcgtt tttccccgga tcatatccgc tcagccgcaa 1155121 tgttgaatcc ttgtctcgat cttcaggcac attatgaatc ggaaaaagaa aataaatttt 1155181 tctataagca atttttgaaa gaagtatcga aaagctacgg aatttctgaa aaagaagcgg 1155241 aagcgattcg ttataaaaca attcaaagct acccgagcgg cgtaccggtt catatatggc 1155301 agcgtatgac cggagctcca tatccctaca gcgtacatgc ggaagttttc aaggaaaaac 1155361 agcaaaagca aggctcaccg gtcgacatga catttcattt atttgagcat ccaagcagaa 1155421 tttatgcatc aatttgcaaa ttctttcata gtcatgaaaa agaattatag agaatataat 1155481 gacaacagcc ttctcttttg cggaggctgt tttgttttgg gaaatgaaaa accggaaggg 1155541 cggcagatgc aatggaatca acgctgattg taggtgcgga cgaatttttc ggcctttcat 1155601 tatgtgagcg aatgatggat gaaggcatac atgttgacgt tgttctggcg gaaacagaag 1155661 ataaaatgag acaaatgtac ttagaagaaa gactcatgtg gcttgggaga aatgaactct 1155721 ttcgccagct tgaacacatt ggagaccaaa attatgatac aatttgtatc cagttcggaa 1155781 gttttttgcc tttagaccaa tatgattctc cttatatttt agtatatgaa gaagaccgaa 1155841 aagaatggga taaacgtgaa aaaacaggct cggaaaaaac cgtgatcctg ccgaaaatgt 1155901 acgggccatg gaaagaagaa acagaggaag acggctatta cacaaacgac gtggctgacg 1155961 agttgctgag attcctgtta gaaccaagcc gtcatagcaa agatcagctt tttgaattgc 1156021 aagtcacaga gaaaacctca aaagaagaag caaaaacaaa aattatcgag tggaaaagac 1156081 aattttcatc aattttcgac aaatattaag aaaaaccttc catgtttcga gttttctaga 1156141 tacaataaac gtataaaaat aatacatgtt atagcttgtc aaaaggagtt gaacatgact 1156201 tgatcacaag gcttgtcatg atcttttctg tcctcctttt attgagtgga tgtggacaaa 1156261 ctccgttcaa aggaaaaatt gagaaggtcg gcatgctctt tcctgatacg attaatgacc 1156321 tcgtatgggg cacaaaaggg tataaaggat tactgaatat acaatccaaa tacaatgtgg 1156381 acgtctatta taaagaaggc gttaaaacag aagaagatat cataaatgcg attgaggatt 1156441 ttcataagag gggcgtcaat ctgctctacg gccatgggag tgaatatgct gaggtgttta 1156501 acttggtcgg cgaagattat ccagatatgg aattcgtcat ttccaatgcg aaagcgaaag 1156561 ctgataatgt aacaagtgtc cattttagcg gggaagcaat gggctttttt ggaggaatga 1156621 ctgctgccca tatgtcgaaa acgaatcagg tcggtgtaat tgcttccttt acgtggcagc 1156681 ctgaggttga cggttttatc aaaggggcca agtatgaaaa tccggatata gaggtaaata 1156741 cgaaatatac ggatcattgg gatgatgata caacagcagt aaagctttat cagaaaatga 1156801 agaacgaagg cgcggatgtt gtgtatcccg ccggagacgg gtataatgtt cctgttattc 1156861 agcaaatcaa aaaagacggt ctttatgcca taggctacgt cacagatcaa tcggatctgg 1156921 gcgagaatac cgtattaacc agcacggtgc aaaatgtgga caaggcctat gaaatcattg 1156981 ctgaacaatt taataaaggc acccttgagg gcggcgatca ttactacgac ctgaacacgg 1157041 gagtcgttga gatgggaaca ttcagcccgc tcgtcgatca agactttcag caaagaatcg 1157101 ccaagctgat caaaacatac aacaaaacag gcgagctgcc aaaaaacgag taatggagtg 1157161 acgtcacatg cagcacgaaa aatcacttga attcttgcaa attgccatga aatatctccc 1157221 tgaagcgaaa gaacagcttg agaaatcagg cattgagctc tcaatggagg ccatccagcc 1157281 gtttatgaat ctatttacaa cggtaatggc ggaagcttat gagcttggca agtctgacgc 1157341 taaatctgaa acagaataag aagaagccac ttttttgaaa gtggcttttc acatgatttt 1157401 ctttttaata gcggagagca tgggcgcaag ctcctttaaa gcgggcttga tttgatcaag 1157461 agagttcata attgaaccga tttggtccat aatatgcatg taattaatcg tctcttcgtc 1157521 gtttgtctga gaaacctgag aaacttcctc ttgctgttcc tcctccttct cttctgttgg 1157581 ttttgctgca tcgccgaaca tcattcttga aaacacatcc aactgcatac gcctcctttc 1157641 catataccat actctatgag taagatgaac tgatagttta gacgaatata ttgccatgtg 1157701 aaaaaaaata ggatagaatt agtacctgat actaataatt gatcacaacc tgattgatct 1157761 tctaaattta agatataaag gagtcttccc taatgaaagc tggaatactt ggtgttggac 1157821 gttacattcc tgagaaggtt ttaacaaatc atgatcttga aaaaatggtt gaaacttctg 1157881 acgagtggat tcgtacaaga acaggaatag aagaaagaag aatcgcagca gatgatgtgt 1157941 tttcatcaca tatggctgtt gcagcagcga aaaatgcgct ggaacaagct gaagtggctg 1158001 ctgaggatct ggatatgatc ttggttgcaa ctgttacacc tgatcagtca ttccctacgg 1158061 tctcttgtat gattcaagaa caactcggcg cgaagaaagc gtgtgctatg gatatcagcg 1158121 cggcttgtgc gggcttcatg tacggggttg taaccggtaa acaatttatt gaatccggaa 1158181 cctacaagca tgttctagtt gttggtgtag agaagctctc aagcattacc gactgggaag 1158241 accgcaatac agccgttctg tttggagacg gagcaggcgc tgcggtagtc gggccagtca 1158301 gtgatgacag aggaatcctt tcatttgaac taggagccga cggcacaggc ggtcagcact 1158361 tgtatctgaa tgaaaaacga catacaatca tgaatggacg agaagttttc aaatttgcag 1158421 tccgccaaat gggagaatca tgcgtaaatg tcattgaaaa agccggactt tcaaaagagg 1158481 atgtcgactt tttgattccg catcaggcga acatccgtat catggaagct gctcgcgagc 1158541 gtttagagct tcctgtcgaa aagatgtcta aaactgttca taaatatgga aatacttctg 1158601 ccgcatccat tccgatctct cttgtagaag aattggaagc cggtaaaatc aaagacggcg 1158661 atgtggtcgt tatggtaggg ttcggcggag gactaacatg gggcgccatt gcaatccgct 1158721 ggggccgata aaaaaaggtg aggtgcacac aagatgacta aaaaaagagt agttgttaca 1158781 ggacttggag cattatctcc acttggcaac gacgtcgata caagttggaa taacgcaatc 1158841 aacggtgtgt ccggaatcgg tccgatcact cgtgttgacg ctgaagaata tccggcaaaa 1158901 gttgccgctg aattaaaaga ttttaatgtt gaagattata tggataaaaa agaagccaga 1158961 aaaatggacc gctttacaca atatgcggtt gtggctgcga aaatggcggt tgaagatgca 1159021 gatcttaaca ttaccgatga gatcgcgccg agagtcggtg tttgggtagg ctccggtatc 1159081 ggaggacttg aaacactaga gtctcaattt gaaatcttct taacaaaagg cccaagacgg 1159141 gtaagcccgt ttttcgtgcc aatgatgatt cctgacatgg cgacaggcca gatttctatt 1159201 gcattaggag caaaaggggt gaactcttgt acggttacag catgtgctac aggaacgaac 1159261 tccatcggtg acgcgtttaa ggttattcag cgcggtgatg cagacgtgat ggtcacaggc 1159321 ggaacagaag cgccgctgac aagaatgtca ttcgccggct ttagtgccaa caaagcgctg 1159381 tctactaatc cagatccgaa aacagcgagc cgcccgtttg ataaaaaccg tgatggcttt 1159441 gtcatggggg aaggtgcagg gattatcgtt cttgaagaac ttgagcatgc cctggcccgc 1159501 ggcgctaaaa tttacggaga aattgtcggc tacggctcaa ccggagacgc ttatcatatc 1159561 acagcgccgg cccaagacgg tgaaggcgga gcgagagcga tgcaagaagc cattaaagat 1159621 gcaggcattg cacctgaaga aattgattac atcaatgctc acgggacaag cacgtattac 1159681 aacgacaaat acgaaacaat ggcgattaag accgtttttg gcgagcatgc gcataaactt 1159741 gcggtaagct ctacaaaatc gatgacaggc cacctcttag gagcagccgg cggtattgaa 1159801 gccattttct ctatcctggc cattaaagaa ggcgtgattc cgccgacaat caatattcaa 1159861 acacctgacg aagaatgtga tttggattat gtgcctgatg aagcccgcag acaggaactt 1159921 aattatgttc tcagcaactc attaggattc ggcggacaca acgcaacatt aatctttaaa 1159981 aaatatcaat cataatcaag ccaaaccggc tgcccttaaa gggtagccgg ttttttttgt 1160041 gtgcatagga ttaaaagagg aggcgatcac atgagtgtag aacaaacata tagctggctc 1160101 aggaaggccg gttcaataga tgatttggcg cattacatta tcccgctttt ttcaggtgcg 1160161 gagaaaaaga actggaaggg cattctgggg catcttcagc atcatgggat gtttaaaaac 1160221 ataaaagagg gtattcagac ggtttccaag ctgaaggaaa aaggttttta cggacatatc 1160281 caaaaggaag aacagtacct caaaaacaaa tggcaaggtc ctgatgtacc aattgttacg 1160341 ctgccggttg atgaacgaaa caggagaatc cgtttagaat tcggatcaaa atcaggactc 1160401 gcctttcaag acaaaatgtt cctttttctt tcgtcagatt tagattttgg gtcggtatct 1160461 gcccttatga cgcatgagta tcatcacgtt tgccggttag gtcatctgac aaaagaggaa 1160521 aaggatgtca cattacttga tacaatcatc atggaagggc tggcggaata tgctgtttat 1160581 gagaggttcg gccgaagtca aacggctgaa tggacgactt ggtatacacc ggaacagctt 1160641 caggctttat atgaaaaaaa gattgcgccc catcgggata tcaaacggga taatcgatta 1160701 tttccccagc tgttattcgg caaaggatat cagccaaaaa tgcttggata cgcagttgga 1160761 ttcaatattg taaaaaaata tttaaccgcc agcaaggcaa gcaccgcaga cgggctgtcc 1160821 attcctgctg agaccttttt ggatgcaatg ctttaaaagg ataaaataat ggaatttcat 1160881 taataatatt acatttatcc taaaaaattc ttgattttgc aaaatgattg taataatata 1160941 caactataaa atttttcgat aattcaatat tatttattat ttctgaataa agggattgct 1161001 ttctcttgaa aacgtttgac aacaagaggg gggaaagggg agctagcatg agcacacttt 1161061 tagaagtgaa taatttaaag acttattttt tcaggaaaaa ggagccgatc cctgcggttg 1161121 acggagtcga ttttcacatc agcaaaggcg aaaccgtcgc gcttgtaggt gaatcgggct 1161181 ccggaaaaag cattacttct ttatcaatta tgggcctcgt ccaaagctca ggcggaaaaa 1161241 tcatggacgg ctctattaaa ctcgaagaca aagacctcac ctcattcact gaaaacgatt 1161301 attgcaaaat ccgcggtaac gaagtatcca tgatctttca ggaaccaatg acctccctta 1161361 atccggtgtt aacaatcgga gaacaaatta ccgaagtgct gatttaccat aaaaacatga 1161421 agaaaaaaga agcccgtcaa cgagctgttg aactcttgca gatggtcggt ttctcccggg 1161481 cggagcaaat tatgaaggag tacccgcatc ggctgtccgg cggtatgaga cagagggtga 1161541 tgattgccat cgcactgagc tgtaatccta aactgctcat tgctgatgaa ccaacgacag 1161601 cgctggacgt gacaatacaa gcccaggtgc tggagctcat gaaagatctc tgtcagaagt 1161661 tcaatacatc gattcttctc atcacacacg acttaggtgt cgtgtctgaa gctgccgata 1161721 gagtgattgt catgtactgc ggacaagtcg tagaaaacgc cactgttgat gacttatttt 1161781 tagaaccgct tcatccgtat acagaaggcc tgcttacgtc aattcctgtt atagatggag 1161841 agattgataa attaaatgcg attaaaggca gtgtgcctac accggataat ctgccgccgg 1161901 ggtgccgttt tgccccaagg tgcccgaaag ctatggataa gtgctggaca aatcagcctt 1161961 cgcttttgac acacaaaagc ggaagaacgg tgagatgctt tttatatgag gaagagggtg 1162021 ccgaacaatc atgacagcag ctaatcaaga aacaatctta gagcttcgtg acgtaaaaaa 1162081 atactttccg atccggtcag gcctttttca aagaaaagtc ggtgatgtaa aagcggtgga 1162141 tggtgtttca ttttcgttaa aaaaaggaga aacactcgga atcgttggag agtcgggctg 1162201 cggaaaatcg actgccggca gaacgatgat cagactgtac aaaccgacag agggccaaat 1162261 tctttttaaa gggcaggata tttccaatct gtcagaggag aagctgcgga agagtgtccg 1162321 caaaaatatt caaatggttt tccaagatcc atttgcttcg ttaaacccga gaaagaccct 1162381 gcgttccatc ataaaggagc cgtttaatac gcacaacatg tataccatgc gtgaacgaaa 1162441 cgaaaaagtt gaagagctgc ttgcaagagt agggcttcac ccgtcgtttg ccggccgtta 1162501 tccccatgag ttttcaggcg gccagcgtca gcggatcggc attgccagag cactcacttt 1162561 gaatccagag ctgatcattg cagatgagcc ggtttccgca cttgatgtat ccattcaggc 1162621 ccaagtgatt aacttgatgg aggaattaca ggaagaattt aatcttacgt atctatttat 1162681 ctctcatgat ctgagtgtcg tccgccatat cagcgacaga gtcggagtaa tgtatcttgg 1162741 caaaatgatg gaactgaccg gcaagcatga gctttatgac aacccgcttc acccatatac 1162801 ccaagcgctt ttatcctccg ttccggttac aagaaaaaga ggttctgtca aacgtgaacg 1162861 cattgtcctg aagggagaac tgcctagtcc ggccaacccg ccaaaaggct gcgtattcca 1162921 cacaagatgt cctgttgcaa aaccgatatg caaggaacaa ataccagaat ttaaagaagc 1162981 tgctcccagc cactttgtgg cttgtcacct ttatagctaa tgttgcccgc acagctttga 1163041 gagggggtat gcacactaca taaacaacag cctagaagaa cgaacatttc aagaggggga 1163101 atatctaatg aaaagacgga aaaccgcact gatgatgcta agtgtattga tggttctggc 1163161 catcttttta tcagcctgct cgggatcaaa atcaagcaac agcagcgcga aaaaatcagc 1163221 aggcaaaccg cagcaaggcg gggatttggt tgttggttca atcggagaac ccacactttt 1163281 taactctctg tattctaccg atgacgcaag tacggatatt gaaaatatgc tgtacagctt 1163341 tttaacgaaa acggatgaaa aactaaatgt gaaattgtca ctcgctgaaa gcattaaaga 1163401 attagacggc ggccttgcat atgatgtgaa aattaaaaaa ggcgttaagt ttcatgacgg 1163461 aaaagaactg actgcagacg acgtcgtatt tacgtacagt gtccctttaa gcaaagatta 1163521 caagggagaa cgcggttcaa catatgaaat gctgaaatcc gtagaaaaaa aggcgattac 1163581 gaagtcttgt ttaagctgaa atataaagac ggtaatttct acaacaatgc gttagacagc 1163641 acagctattc tgccgaaaca tattctcggt aatgttccga ttgctgattt agaagaaaat 1163701 gagtttaaca gaaagaaacc aatcggttca ggaccattta agtttaagga atggaagcag 1163761 ggccaatata ttaagctcga agcgaatgat gattactttg aaggaagacc gtatttagat 1163821 actgtgacgt ataaagtcat tcctgacgca aatgctgccg ttgctcagct gcaggcaggc 1163881 gatattaatt tctttaatgt gcccgccact gactacaaaa cggctgaaaa attcaacaac 1163941 ctaaaaatcg ttactgattt ggcattaagt tatgtgtaca tcgggtggaa tgaaaaaaat 1164001 gaattattca aggataaaaa ggttcgtcaa gcgctaacaa ccgctcttga ccgcgagtca 1164061 atcgtcagcc aagtattaga tggagacggc gaggtagctt acattccgga aagcccttta 1164121 tcttggaact atcctaaaga tatagatgtt ccgaaatttg agtacaacga gaaaaaagcg 1164181 aaacagatgc ttgcagaagc cggctggaaa gatacgaacg gtgacggcat tctggataaa 1164241 gacggaaaga aattctcgtt tacccttaaa acgaaccaag gaaacaaagt ccgtgaagac 1164301 atcgctgtcg tcgttcagga acagctgaaa aaaatcggca ttgaagtgaa aacccagatc 1164361 gttgaatgga gcgctctcgt tgaacaaatg aatcctccga attgggattt tgatgcaatg 1164421 gtcatgggat ggagtttatc cacattcccg gatcaatatg atattttcca ttcaagccag 1164481 attaaaaagg gtttgaacta cgtttggtat aaaaatgccg aagcggataa actcatgaaa 1164541 gatgcaaaat caatcagtga cagaaagcag tattcaaaag aatatgagca aatctatcaa 1164601 aaaattgcgg aagatcagcc gtatacgttc ttgtattatc ctaacaacca tatggcaatg 1164661 ccggaaaatc ttgaaggata caaatatcat ccgaaacgtg atttgtataa tattgaaaaa 1164721 tggtggcttg caaaataaat ttcccttaaa ggggagggag agcgttttct ccctcttctg 1164781 tttttaataa ggaaagtaaa gggggacaag tatatggctg catatattat cagaagaacc 1164841 ttaatgtcta tcccgatttt attgggaatt acgattttat catttgttat catgaaagcc 1164901 gcgcccggag atccgatgac attaatgatg gacccgaaaa tcagccaggc tgacagagag 1164961 cagtttattg aaaaatacgg tctgaatgat cctcagtacg ttcaatattt aaagtggcta 1165021 ggcaacatgg tgcagggtga tttcggaacg tctattgtca gaaaaggaac gcctgtttca 1165081 gaattgatta tggcaagact acccaatacg ctcctgctga tgctggtttc aacgattttg 1165141 gctcttatga tttctattcc gttcggtgtc ctgtcggcaa agcggccgta ttcaaaaatc 1165201 gactatggca ttacatttac ctcgtttata ggcctggcta ttccaaactt ttggtttgga 1165261 ttaattttga ttatggtgtt atcggtaaat ctcggctggt ttccaactgg gggtgtcgag 1165321 acactgaata ccgaattcaa tatatttgac cggattcatc atttaattct gcctgcattc 1165381 gttctagcta cagctgacat ggccggactg acgagataca cgagatccaa tatgcttgat 1165441 gtattaaatc aagattatat tcgcacagcg agagcaaaag gatttaaaga gaacagagtg 1165501 ctatttaaac atggattgag gaatgcatta ttacccgtca ttacaatttt cggtttgatg 1165561 attccttcat ttatcggcgg atctgtcgtt gtcgaacaaa ttttcacttg gccgggatta 1165621 ggaaagctgt ttgtcgattc agcattccag cgcgattatc cggttatcat ggcaatgact 1165681 gtgatctcgg cggttcttgt cgttgtcgga aacctcattg cagacatcct ttacgcgatt 1165741 gttgatccgc ggatcgaata ttaaaaggag ggaaacagag atgtcagagc tgcaaacaac 1165801 tccctcgccg gagatcaggc tgaaagaaaa tatttcgaaa aagccagaaa caatgacaaa 1165861 gattttctgg gaaaaattct cgaaaaacaa actggccatt ttaggtgccg ttattctttt 1165921 tatcattatt atgtctgctg ttttcgcccc tttaattgca ccttatcccc aagagcagca 1165981 aagcctgctt gataaatata aggcgccggg ccttgaacat ctgatgggaa cggataaatt 1166041 tggacgtgat attttcagcc ggatcctata tggagcgcgt gtctctttat tggttggatt 1166101 tgcgtccgta gtcggttcga ttttgatcgg aacggtttta ggagcattag ccggatattt 1166161 cagaggaata gtggatgctg tcattatgcg tgtagttgac attgtgttat ccattcctga 1166221 tattttcttg ttgatcacgc tggtcaccat cttcaagccg ggtgtggaca aattgatttt 1166281 aattttctgt ctcacaggat ggaccacaac agcacgatta gtaaggggag aattcttgtc 1166341 gctccgttca agggaatatg ttcttgctgc taaaacaatt ggaacaaaaa cgcacaaaat 1166401 tattttttct catatcctgc ccaatgcgtt agggccgatt atcgtgtcag ctacgctgaa 1166461 agttgggtct gttattctag ctgaatcggc gctaagctac ttgggctttg gaatccagcc 1166521 gccaatcgct agctggggga acatgcttca agacgcacag aatttcacag taatgattca 1166581 agcatggtgg tacccgttat ttcccgggct atttatttta atgaccgttt tatgcttcaa 1166641 ctttgtcggt gatggcctgc gggatgcgct tgacccgaaa aatattaaat aaaaatgaat 1166701 atcatatctg ttataaaata tcaccaaatc agaaaaaagc aggtctcctt tagtcagaaa 1166761 atatacaaag agatctgctt tttatgattc ttacataaac ccagtgattc cagatttcct 1166821 caatctcttt ggaataattt ctctatccct tgcctatact gtggacaaca gtttttataa 1166881 aagtgagggg ttagagatgt tatttcttca tgatgtgtgg gtcaattggt ttgaagggga 1166941 agaaaatggc tacaatgtat gccactttca cgaatggcgc aaggaagata cggttgagct 1167001 tttggatcag gtgccgctgt taagggtgcc gtcagtactg tttcattaca tagaaaacga 1167061 tttgtcagag cttccgaaag gtttgcttga agacgtacat cagaaatcgt acattcgaaa 1167121 aaatcatgag cggacaaagc ttgagtattg ttttgtcgta acagacggaa tcggcatttt 1167181 agctgttgac acgatcggct acacgatccc tgtcagaaaa agccgtctaa tcccaagaca 1167241 ggagcagctc gtttatgaaa tggtaaaaga tgtagagcct gaaacatatg aatttgagcc 1167301 aaagaagctg gaatcctcca aggaatatca catcttatca ttagcaccag aacatgtcag 1167361 aggactgaca agaaaagaac ggcaaattaa gcagctgatg tttatggcgc ttgaccaatt 1167421 aaaagggctg aaaaaccgag cggaaattgg ctactggtac acagagtgga atccgcatat 1167481 gtatgaacaa atcaaaagga tgagctttga agagatttgg gacatgctgt ataacgaaac 1167541 aattgaaggc tggtcggaca aacacctagc tttttgcgaa aacctaataa aaggacagcc 1167601 ttttttcgaa aagctttggg aaatggaaaa cgaatcaaag gtcaactgaa aaaaaccgct 1167661 ctttgcaaag agcggttttt tgattagcgt ctttttcttc caagacccat ggcattctcc 1167721 atttttttca gcattttgtt tgctgtccga ttcgctcgtt ccgcgccttc atcaagaatc 1167781 cggtctaatt cttcagattc tatcagctcg taatagcggt cctggatcgg ttttaatgcg 1167841 ttcactacga cttctgccaa atcaccttta aactcgccgt agccttttcc ttcgtacttt 1167901 gcttcaagct cttcaattgt cgtattgccg aggattgaat aaattgtaag aaggttggaa 1167961 acgcccggtt tgttttcctt atcaaatttg acaatgcctt cagaatccgt tactgcgctt 1168021 ttgattttct tttcaagctg cttcggctca tccagcaatg taatataagc tttctgattc 1168081 ggatcagatt tgctcatttt cttcagcgga tcattcagag acatgatacg tgcaccgact 1168141 tttggaattt tcacttccgg aatcgtaaag atgtcgttgt attttttgtt gaagcgttct 1168201 gcaagattcc gcgtcagctc aaggtgctgc ttttgatcct cgccgacagg tacaagatcc 1168261 gttccgtaca gcagaatatc agcggccatc agcggcggat atgttaacag gccggagacg 1168321 acagcttcat tgcctttgga tttgtcctta aattgagtca tccgctcaag ctcgccgata 1168381 taggcgacac actgcatcat ccatccggcc tgcgcatgtg cggggacctc tgactgaata 1168441 aacaatgttg ctttttctgg atcaagtccg acagctaagt aaagcgccgc gagattgcgg 1168501 atattctttc taagctcaag ccggtcttga ggaacagtta tcgcatgctg atcgacgatg 1168561 caaaaatagc tgttataatc atgctgcagt tcgacaaact gcttcattgc accgatatag 1168621 ttgccgagcg tcactgagcc gcttggctga atgcctgaaa aaatcgtttg tttcatgaaa 1168681 acatcaacct catttcttaa aacataataa aaaaggctca ttcttcccct gtaaaaaagg 1168741 gacgaatgaa ccgtggtacc accctgatta ttccattaaa atggaatcac tctgacgttt 1168801 gtaacggaga ctgctccggc tgagcctact tttttccagt tcggtcagct gctccaaagt 1168861 ccattccaca ttgcccgtta tctgctccca gcaccgcaga ctctcttcaa acaggtgaaa 1168921 cgtgtactac tctttttcat agcaagcttt tcttttgatt gcttcattat aaatcaatta 1168981 taaccaattg tcatcatgaa aaaacattct tttttccagt aaaattgtaa taatataaat 1169041 aacacgagtg ctgtaaaatc cttaaatgat aactgctatc agcgtaaaaa caggcagata 1169101 ttatatgtaa aaagcaatat gggcagaaaa cacatgaaaa agtttttaat caatttatgc 1169161 tttaaatggt agaaggatat tatgttcatg gaagaaaaac taacgaagtt taaatatttt 1169221 aaattgataa aataatattg caataaatta tttgtttcat tataatgaac ttgttcactc 1169281 tattgttaca gcttttttac aaaaataatc agaaaagacg gaacagaata aaagttgtgg 1169341 aaactcaggt tcatttgtct gatatttctg aggatttagc cgtaaggagc tgaaaattat 1169401 tattaggggg tttgcgaata tgaaaaaacg ttggtcgatt gtcacgttga tgctcatttt 1169461 cactctcgtg ctgagcgcgt gcggctttgg cggcagcgga tcaaacggtg aagggaaaaa 1169521 ggacagtaaa ggaaagacga cacttaacat taatattaaa actgagccgt tctccttaca 1169581 tccgggattg gcaaatgatt cagtatcagg cggtgttatc cgtcagactt ttgaaggatt 1169641 gacacgtatc aatgcagatg gtgagcctga agaaggcatg gcttctaaaa ttgaaacgag 1169701 caaggacgga aagacatata catttaccat tcgtgatggt gtgaaatggt ctaatggaga 1169761 ccctgtaact gcacaagatt ttgaatatgc ttggaaatgg gcgcttgacc ctaataatga 1169821 atcacaatac gcttaccagc tctactacat aaaaggtgct gaagcggcga ataccggaaa 1169881 aggcagccta gacgatgtgg cagtaaaagc tgtgaatgac aaaacgctga aggttgaatt 1169941 aaataacccg actccatatt tcactgaatt aactgcgttc tatacgtata tgccgatcaa 1170001 taagaaaatt gcagagaaaa ataaaaagtg gaatacaaat gccggagatg attatgtatc 1170061 aaacgggccg ttcaaaatga cggcatggaa acacagcggc tctattactc tcgaaaaaaa 1170121 tgaccagtat tgggataaag acaaagtcaa actgaagaaa atcgatatgg ttatgatcaa 1170181 caataacaat acggaactaa aaaaattcca agctggcgaa cttgattggg ccggtatgcc 1170241 gctcggacag cttccgacag aatccctgcc gaccctgaaa aaagacggtt ctttacatgt 1170301 tgagccgatt gcaggagtgt attggtacaa attcaacact gaagctaagc cattagacaa 1170361 cgtcaatatc cgtaaagctt taacatattc gcttgaccgt cagtcgattg ttaaaaacgt 1170421 tacgcaagga gagcaaatcc cggcaatggc tgcagtgccg cctacaatga agggatttga 1170481 ggataacaaa gaaggatact tcaaagacaa tgatgtcaaa acagcaaaag aataccttga 1170541 aaaaggccta aaagaaatgg gcttaagcaa ggcatctgat ttgccaaaaa tcaaattgtc 1170601 ttacaacact gatgacgcac acgcgaaaat cgctcaagca gtacaagaaa tgtggaagaa 1170661 aaatttaggc gttgatgttg agcttgataa ctcagagtgg aatgtctata ttgataagct 1170721 ccacagccaa gattatcaaa tcggccgtat gggctggctc ggcgacttca atgatcctat 1170781 caacttcctt gaattgttcc gcgacaaaaa cggaggaaat aacgatacag gctgggaaaa 1170841 tccagaattc aaaaagcttc tgaatcagtc acaaactgaa acagataaaa caaaacgtgc 1170901 agagctgctg aaaaaagcag aaggtatttt cattgatgaa atgccggttg ccccaatcta 1170961 tttctatact gatacttggg tacaggatga aaacctaaaa ggtgttatca tgccaggtac 1171021 tggtgaggtt tatttcagaa acgcatattt taaataaggc tacgtctgaa aataaaagac 1171081 ctcaaggtat atggggagaa aagccccata tacctttctt actgatggag tataaaaatg 1171141 taaaaaccat ggaggtgttc ccccttgcta aaatatatcg gaagacgctt agtctatatg 1171201 attatcacac tatttgtgat tgtaactgtg acattcttct taatgcaagc agcaccgggc 1171261 gggccatttt caggtgagaa aaagcttccg cctgaaattg aagcaaattt aaatgcgcat 1171321 tatggcttgg acaagccgct gtttgtacaa tatgtcagtt atttgaaatc agttgcaatg 1171381 tgggatttcg gaccgtcatt taaatataaa ggtcagagtg ttaacgacct gatcagttca 1171441 ggtttccccg tttcatttac tcttggagca gaagctattc tcctcgcttt agcgttaggt 1171501 gtattgtttg gggtcattgc agccctttac cataataagt ggcaggatta taccgtcgcg 1171561 attttaacga tatttggtat ttcggttccg agctttatca tggcggctgt tctgcaatat 1171621 gtgttctcca tgaagcttgg gctgtttccg gtcgcggggt gggattcctg ggcatacacc 1171681 tttttgcctt ccatcgcact tgcttccatg ccgatggcgt ttattgccag actttcccgt 1171741 tcaagcatga tcgaagtgtt aaacagtgat tatatccgca cagcgaaagc gaaagggctt 1171801 tcccgcccag cggttacagt gcggcacgcc attcgaaacg cacttttgcc ggttgttaca 1171861 tatatgggcc cgatggccgc acaggtctta acggggagct tcattattga aaccattttt 1171921 gggattccgg ggcttggtgc acacttcgtc aacagtatta caaaccgtga ttatacggtc 1171981 attatgggtg taacggtgtt cttcagtgtc atcttgctat tgtgtgtatt aatcgtagat 1172041 gtgttatacg gcattattga tccaagaatc aagctttcca aagcaaagaa aggagcctag 1172101 gccatgcaga acattccaaa aaacatgttt gaaccagccg cagcgaatgc cggcgatgca 1172161 gaaaaaataa gtaaaaagag cctttccctc tggaaagatg cgatgcttcg cttccgcagc 1172221 aataagcttg caatggtcgg gcttatcatt atcgtactta ttatccttat ggcaattttt 1172281 gcgccgatgt tctcaaggta tgattattca actactaatc tcttaaatgc ggataagccg 1172341 ccttcaaaag atcactggtt cggaacagat gatcttggac gggacatttt cgtccgtaca 1172401 tgggtagggg cgcgaatctc aatctttatc ggtgttgcag ctgctgttct cgatttgctg 1172461 atcggcgtca tttgggggag catttcaggc ttccgcggag gaagaacaga tgaaatcatg 1172521 atgcgtatcg ctgatatcct ttgggcagtt ccttcattat taatggttat cttactgatg 1172581 gttgttcttc cgaaaggtct atttacgatt attattgcca tgacgattac aggctggatt 1172641 aatatggcca gaatcgtgcg cggacaagtg ctgcagctga agaatcagga gtatgtgctt 1172701 gcttcacaga cactgggtgc aaaaacatcc cgtcttctat ttaaacatat cgtgccaaac 1172761 gcaatgggtt ctattttggt cacgatgaca ctgacagttc ctactgcgat ttttacagaa 1172821 gcctttttaa gctatttggg acttggtgtt ccggctccgc tggcaagctg gggaacgatg 1172881 gcttctgacg gattgcctgc attgacctat tatccgtggc gtttattctt ccctgccgga 1172941 tttatctgca ttacaatgtt tggttttaac gttgtcggcg acggattaag agacgcattg 1173001 gatcctaagt tacgtaaata agggagtgat acgggtgaca cgcctattag aagtaaaaga 1173061 tttagcaatt tcatttaaaa catatggcgg agaggtccag gcgatccgcg gagtgaattt 1173121 ccatctggat aaaggggaga cgctggccat tgttggagaa tcaggttccg gaaaaagtgt 1173181 aacctctcaa gcgattatga agctgattcc aatgcctccg ggttatttca aacgcggtga 1173241 gatcctgttt gaaggaaagg atctggtgcc gctgtccgaa aaagaaatgc aaaatgtccg 1173301 gggaaaagag atcggcatga tattccaaga tccgatgacc tctttaaatc caacgatgaa 1173361 ggtcggtaaa caaattacgg aagtgctttt taaacacgaa aagatctcga aggaagcggc 1173421 taaaaaacgc gcggttgaac tgctggaatt agtcggtatc ccaatgccgg aaaagcgggt 1173481 gaaccaattt ccgcatgaat tttcaggcgg gatgagacag agggttgtca ttgccatggc 1173541 gcttgcagcg aatccgaaac ttctgatcgc cgatgagccg acaactgctc ttgatgtaac 1173601 gattcaagcg caaattttgg aattaatgaa ggatttgcaa aagaaaattg acacgtccat 1173661 catctttatc acacacgatc ttggtgttgt ggctaacgtt gctgaccggg tcgctgtcat 1173721 gtacgcggga cagattgtag aaactggtac ggtagacgaa atcttctacg acccgagaca 1173781 tccgtacact tgggggcttc ttgcatccat gccgacactg gaaagttcag gagaggaaga 1173841 gctgactgca attccgggca cgccgcctga tttgacaaac ccgccaaaag gagatgcttt 1173901 tgccctgcgg agctcttacg cgatgaaaat cgattttgaa caggagccgc caatgtttaa 1173961 ggtatccgat actcattatg taaaatcgtg gctgcttcat cctgacgcgc caaaggtaga 1174021 gccgcctgaa gcggtaaaag cgaaaatgcg taaactggca aacacgtttg aaaaacctgt 1174081 cttagtgaga gaagttgaat gaattgactg aaaaactatt agaaatcaaa catttaaaac 1174141 agcactttgt cacgccgagg ggaacggtta aggctgtaga tgatttatca tttgatatct 1174201 ataaaggtga aacattaggg ctggttggtg aatctggctg cggtaaatcg acaacaggcc 1174261 gaagcattat caggctgtac gaagcaaccg atggtgaggt gctgttcaac ggcgaaaatg 1174321 tgcacgggag aaaatcgcgg aaaaagctgc tggaattcaa ccgcaaaatg cagatgattt 1174381 tccaagaccc ctatgcatcc ctgaatccga gaatgacagt tgctgatatt attgctgaag 1174441 gccttgatat tcataagctg gcaaaaacga aaaaagagcg gatgcagcga gttcatgaac 1174501 tattggaaac agtgggattg aacaaggaac acgcgaaccg ctatcctcat gaattttccg 1174561 gcggccagcg ccaaagaatc gggattgcca gagcgcttgc tgttgatccg gaattcatta 1174621 tcgcggatga gccgatttcc gctttggatg tatccattca agcgcaggtc gtgaatttaa 1174681 tgaaagaact gcaaaaagaa aaagggctca catacctgtt tattgcccac gatttatcga 1174741 tggtcaaata catcagtgac cgcattggcg tcatgtattt cgggaaactg gttgagcttg 1174801 cgccggcaga tgagctttat gaaaatccgc ttcacccata tacaaaatca ttgctttctg 1174861 cgattccgct tcctgatccg gactatgaga gaaatcgcgt tcgccagaaa tatgatccgt 1174921 ctgtccatca attaaaggat ggggaaacga tggaattccg tgaagtcaaa ccgggacatt 1174981 ttgtgatgtg cacggaagcc gaatttaaag ctttttcatg attcatcaat ccttcaagag 1175041 atttctcttg aaggattttt ttgcgtcttc atagaaagtg agaatgataa catttacaat 1175101 tagaggaaaa agcggaggcg aaatacgatt caatttctgc ataacaaaaa tgtttttgcg 1175161 ctattgctgt ctcaatcttt tcaatcttta gcaggagtcc tcgtcacaat cgttttaatg 1175221 gtccggatct atcaaatgac tgactccgtt tttttggcgg gccttatttt atcgttcatg 1175281 tcgtttgcga gtatagcagc aagcttttgc gtctctccgg tgcttcgcat tctcggtttt 1175341 aaaaaggtgc ttgcgggagc gaatctgctg agagcggtct ttattatact gatggcatac 1175401 agcgtcactc atcacggaca ggcattcttt tggattacgc tgctgtttgt gttttgtttt 1175461 tccttcgcgg gcgctttttt tcagccggca agatttgcgc tgctgccgat tattgttcca 1175521 aagaagcaat atgtaaaagc gaatggtgtg atctccctct cgaatcaatt gttcttaaca 1175581 gcaggctggg gccttggagg ccttctgacg tacgccgtcc cttttgaact cgttgtcggc 1175641 gctgccattt gcctgtttgt tctatcggga gcttccatca gtgtgctgca tgtaaatgaa 1175701 gaagaggctg caggaactgc tgaaacagca tctgtcagaa gtatatggaa ggatttaatg 1175761 atcatcccta ttgtaagaga cattactgta atggacatgt tagaagcttt ggcgggttcc 1175821 gtatggtcat ctgctattct cctcgcattt actgcggctg ttttgcatga aacagaggtg 1175881 tggtggggga tgtttaacgc ttcctatttt ataggcgcaa ttgtcggcag tgtgattgct 1175941 attcgttttt cttctttttt tgagcggaat atgggctatg ccattatgtt cagctcgctt 1176001 gtaatgtcgg cgctgaccct tttgttttca ttttctccag tcccattttt atgcgctctg 1176061 gcttgtgctg caatggggcc tttttatcag gtgcgtgata tttgccagga aaccatgctg 1176121 caggaagtta ttcccgagca gaaacgaatc ggaatcatgg ctgcaaaaaa tgcgattttg 1176181 actccttggt caggcgtcac ctactccatt atggggctag tggctgatgc tgctggtgcg 1176241 aaaatagctt ttatcgcggc tgctgcatta tatatcatga catttctgat tgcactggcg 1176301 cagccccgtc tggttcatta caggcgagaa aatcgagttc aatgagaaac acttcaaaat 1176361 gaacggagca gctggctccg ttttgctgaa aaaaaaatga aaccatggcg gaagttcgca 1176421 cgtctttata gatgtaaggc tgtttaaaca agaagaaatg gggtatatct aaaagtatga 1176481 agacaacgaa ctcataagga gcaaatcaat gaactggtat gaaaagctta gcgagtactt 1176541 tccaattgaa gaaatgaaat caaaagcgca tatggaagct cttctgaaag agcgaagcga 1176601 tatttatcat aaagatgaag gcaaacatca tattttaatg tttgcggaat tcgattcttt 1176661 tatcttcgtt gattatctgt atgtgtctaa ggatgcaaga gggcaggggc ttggcggcaa 1176721 attgatcgcg aagctgaaaa agaaaaataa gcccatattg ctcgaggtgg aacctgtgga 1176781 tgaagatgat actgatacag aaaaacgcct gaggttttat caaagagagc atttcaagca 1176841 tgctcagtca attgggtacc ggcgccggtc attggctacg aatgaagtaa acaagatgga 1176901 gattctgtac tggtcaccaa aaacagaatc agaagaagaa attcttgaag ccatgaaaca 1176961 gacatatgaa aacattcata cttataaaga tgagaaatgg tacggagaat cgtacgaaaa 1177021 aacggatgag gtcttggaaa tcatcgatga agaaaaacaa aaaaatattt tcgatcagtt 1177081 aagctaattg agaataagaa catatcatga acattaaaaa tttgctggat tgacacattt 1177141 ttttcttagg atactgttca cacttacttt tttatagtat aatacctgta aagattcctt 1177201 ttttagagta atttcaattt aagaataaaa tagatgttca tcctactaat tagaggagtg 1177261 aagatgaatg gttacactat acacatcacc aagctgtact tcatgcagaa aggcgagagc 1177321 gtggctcgag gagcacgaga ttccatttgt agaaagaaac attttctctg aacctttatc 1177381 aattgatgaa ataaaacaaa ttcttcgaat gactgaggac ggaacagatg aaatcatctc 1177441 aacccgttca aaagtattcc aaaaactgaa tgtgaacgtt gaatctatgc cgctgcaaga 1177501 tttgtaccgc ttgatcaacg agcatccagg tttgcttcgc cgtccgatca tcattgacga 1177561 aaaacgtttg caggtcggat ataacgaaga cgaaatcaga cgtttcctgc caagaaaagt 1177621 tcgctctttc caattaagag aagcacagcg tttggcaaac taatagatcg tatcatcaaa 1177681 agaaggctga gtcatcagcc ttcttttatt tttcaacctg ctggtaataa atgctcgcaa 1177741 ggatgacaaa cgcaaccgtc aaaatgggga ggagcgtttc gactgtgccg tgctgcgcca 1177801 taaaaagcga cagctttttg tctctgacaa tcatttctcc gccagtataa gcaagcagcc 1177861 cgcttcccgc gtaaatcaga agcggtattt tctctagtgc aatatggatg agtttgctgc 1177921 cccaaataat aaccggaacc gatacacaca atcctataac aacgagagaa aactcaccgt 1177981 gtgaagctcc cgcaactgcg atgacgttgt ccagcgacat aaagagatct gcaagcacaa 1178041 tcgttcgtat cgctctccac agggaggtgc tgcttttaat gtgtttcgtg tctttttttt 1178101 caatcagcag ctgatatcct aaatacagca ggaaaattcc gccggcgcac tgcaagaacg 1178161 gaatgttcaa aagatatact gctgcacttg ttaatccgat tctcatggca acggcaataa 1178221 atgttccgag aataatggct tgctgtcttt gcttgtccgg caaatgtctg ctggccatgg 1178281 caataacaac cgcgttatct ccgccgagga tcaggtcaat cccaacaatg acgagcagag 1178341 aaatcagata gtcatgctcc atgaagcggc acctcgcttt cagtccttcg cttgtactac 1178401 tactatatga gacaggtcat attttatgat atcagccgcc tgatctgccg ttttttaggc 1178461 aaaggtgcat ttttatttct tttgtgactg ttttatcata aaatagaaat acaaaggaat 1178521 tcacactggc cttggttaag gttaagatgt ggacggaatg ggtaaagtgt agtaaagtac 1178581 aattaatcgg gagcttagat gtcccttcaa catcttatat agaagggaag gttggcaaat 1178641 ggaaattgaa agaattaacg agcatacagt aaaattttat atgtcttacg gagatattga 1178701 agatcgcggt tttgacagag aagaaatttg gtataaccgt gagcgcagtg aagaactttt 1178761 ctgggaagtc atggatgaag ttcatgaaga agaggaattc gctgtggaag gcccactttg 1178821 gattcaagtt caggcactgg acaaaggatt agaaatcatc gtcacaaaag cccagctttc 1178881 caaagacgga caaaagctcg aactgccgat tcctgaggat aaaaagcaag aaccagcatc 1178941 tgaggatctt gacgccttgc tggatgattt ccagaaagaa gagcaagccg tcaatcagga 1179001 agagaaggag caaaagcttc aatttgtctt gcgatttggc gattttgagg atgttatttc 1179061 tctatctaaa ttgaacgtta acggaagcaa aacgacttta tattcgtttg agaaccgata 1179121 ttatttatat gtagattttt gcaatatgac tgatgaagag gttgaaaatc agctaagcat 1179181 cctgctggag tacgcaactg aatcctcaat cagcatacac cgtcttgaag agtacggcaa 1179241 gctgattatt tcagagcatg ctctagaaac gataaaaaaa cactttgcat catagcaaac 1179301 cgatttcctt ccggaaatcg gtttttttta tgcacgaaaa tgccatttta gagatgtgaa 1179361 aaatcaaaaa catatagaca agcagaaaat acagcgaaca ggagttgatc atcttttcca 1179421 gaaagtatac ttcatctgga aaggagagat gacaattgtt tagtgctgtg actgaagacg 1179481 gccaaatgtt tcaccttcta ggcgctcagc aaaaccagaa attaaagcgg agacggttct 1179541 tctgtccggt atgcggggga gagctagctg tgaagctcgg acttcaaaaa gcgccgcatt 1179601 ttgcccataa acagaacaag tcctgcgcca tagacatcga gccggaaagc gcctaccact 1179661 tagaaggaaa aagacagctg tatgtatggc tgaaaacgca acgggcttca ccaatattgg 1179721 agccgtatat aaggacaatc aaccaaagac cggacgtcat ggcaagaatc aaggagcata 1179781 tgcttgctgt tgaatatcaa tgcgccacta tcgctccaga tgtctttcaa aagcggacag 1179841 agggcttcaa acaagaagga atcatcccgc agtggattat gggatacagc cgcttaaaac 1179901 ggactgcttc gtccttttat cagctttcaa cttttcattg gcagtttatc aatgcaagtc 1179961 catacagaga actgatatgt tattgtcctg aaaggcgttc ttttctccgg ctcagccaca 1180021 tcattccatt ctacacaaac cattcttatt cctcagtcca aacgatccct atccatcggg 1180081 caggtgcagg cgatcttttt ttcactgaac cgaaaccctc aattcaatat tcaggctgga 1180141 cgaaagcgat tcaccgtttt cgccataaac cccatcggtt taactcaaag gaaacaaatc 1180201 gccttaggct gctgttttat gagaaacgac agacgccttt ttcttttctg ccgactgaag 1180261 tgtttgttcc tgttagaaaa ggggcagttt ttaagagtcc ggtttttgtg tggcaggggt 1180321 ttctttattt gtttatgacg gatcttggag gtaaacgtgc gccaattcgt ttttcagccg 1180381 ttttgcagca gtgcaaactg cacattcata ataagaacat tgcactcagg tccgaatgca 1180441 gcgaagagtg tctttcagaa gcggttaaac agtatattga ttttttgtgc aagaagggat 1180501 ttttaaggga gactcagaaa gaagtatatg tgctgaatca gcctgcagga ggcatacact 1180561 ccatgcagga tctcatagaa agagaccgca gctgttttat agaatgagtt tgtcttattt 1180621 ggctcaccct aagacaaagg tggtgggcag gctgtgaaag gcacaaaagg aaaggttttt 1180681 cgtgttttta ctgctttttt ggcattcgtt ctcttcatta ctgcatatga tttgacaaaa 1180741 ggcagtgaaa aaccggaaga tattcacaac acaagtttat tgagaaacag ctgttttttc 1180801 aattggcttg aatcaaagaa gacgaggggg atcaccatgg ctgaggaaaa aaaagcaaac 1180861 caactgcctg acagaagtga ggtaaaggca gaagacacat ggagacttga ggatattttt 1180921 cctagtgatg aggcctggaa taaagaattt caagctgtaa aagaattaat tccgaattta 1180981 tctaagtata aaggaaagct ggcagattca gctgatcatt tatacgaggc tcttacgtat 1181041 caagataaag tgatggagcg gctaggtagg ctgtacacat atgcgcatat gcgctctgac 1181101 caggatactg ggaactcctt ttaccagggg ctgaatgaca aggcgggaaa cctgtataca 1181161 caggccgcaa gcgcgacagc ttatttggtt ccggagattt tatccataga agaagacaaa 1181221 ctgcagcagt tcattcttga aaaagaagaa ttgaagctgt actctcatgc gattgaggag 1181281 attacaaagg aacgtccgca tgtgctgagc gagaaggaag aggcgctgct tgctgaagcc 1181341 tccgaggtac tggggtcatc ttcaaataca ttcagcgtgt taaataacgc agatataacg 1181401 tttccatcca ttaaagacga agatgggaat gaaaaacaga tcactcacgg caactttatt 1181461 aatttcttgg aaagtgaaaa ccgtgaagtc cgcaaaaatg cgtttgacgc agtgtataaa 1181521 acgtacggac aatataaaaa cacaatggcc acgacgctaa gcggcactgt gaaaaaggac 1181581 aacttctacg cgagagtgaa aaagtacaag tccgcgcgtg aggctgcgct ttctaacaac 1181641 agtattcctg aggaagtata cgataacctt gttaagacga ttaataagca tttgccgctc 1181701 ctgcaccgct atattgcgct aagaaagaaa gtgcttgagc ttgatgaagt gcatatctat 1181761 gacctgtata caccgcttgt gaaagatgct gggatgaagg tgacatacga ggaagccaaa 1181821 gattacatgc tgaaaggcct cgcaccttta ggggaagaat atgcctctat cctaaaagaa 1181881 ggactggaaa accgctgggt ggacgtttac gaaaataaag gcaaacgcaa tggggcttat 1181941 tcatcaggag cttacggcac gaatccgtat attttgatga actggcataa taacgtcaat 1182001 aatctcttta cgctcgtgca cgagtttgga cattccgtac acagctacta tacgagaaag 1182061 caccagcctt atccatacgg caattacagc atctttgtcg cggaagttgc ctctacgaca 1182121 aatgaagcgc tccttggcga atatttgctg aacaatttag aggatgaaaa acagcgctta 1182181 tatattctca accatatgct tgagggcttc aggggaacgg tcttcagaca aacgatgttc 1182241 gctgaatttg aacatctgat tcatacaaag gcgcaagaag gcgagccgct tacacctgag 1182301 cttctgacaa atgtctatta cgacctgaat aaaaagtatt ttggagacgg catggtgatt 1182361 gataaggaaa tcggccttga atggtcgcgt attccgcact tctattacaa ttactatgtg 1182421 tatcagtatg cgacaggtta cagcgctgcc caagcattaa gcagccagat tttgaaggaa 1182481 ggaaagccgg cggttgaccg ttatattgac ttcctgaaag cgggaagctc acaatacccg 1182541 attgatgtcc tgaaaaaagc gggtgttgat atgacgtctc cagagccaat cgaagccgcg 1182601 tgcaaaatgt ttgaagaaaa acttgatgaa atggaagagc tgctgatgaa agtcaagcag 1182661 tcttaaaaaa gtaagcctgt gcggaaatga cgcacaggct tttttaaaac cctttaaagg 1182721 ttttccggtg attcaagcgg tagagggtaa acaaaataga cagaaacagc agaggagagg 1182781 taatataaag cggcagcata tgcatcatgc ctaagatatt caagcagaaa aaaacagcaa 1182841 tgcacacaat tgagatcaaa gtagacatca tggcggtcct cctcgtcctt tttccttata 1182901 aggatatgag tgaatgcact tcgttatgtt ttgtgacaaa aatatgaaca ttaagcatag 1182961 aggttgtcaa aagtcgacat cttttgttat cataaggatg tgaaattgat cacaaacaaa 1183021 cattacccct ttgtttgacc gtgaaaaatt tctcccatcc cctttgttgt cgttaagaca 1183081 tatgaaaccg cgcttatccc ggcgcggttt ctttagtgct aaaaatggaa cgtacgtttg 1183141 gttatggcat aaaaaaacag cctcaagcat atgcacgcct gcggctattt ttcacatgat 1183201 tgatattcat cagaataagt gctgagagac ttccaaaaca ttccgtgttt ggcttccact 1183261 ttggcaacct ttttagcaaa cgccagtttt ttcatttctt tttctacctc ttcaaggctc 1183321 aggtcatata caagagcaat ttccttcgag gcaacgaagc ggaaatattc aataaaacat 1183381 tctaaaggcg gtgtttccga cggcttcggc tcgtcgccaa gcatctcaaa taaaatttct 1183441 tcatatacat catatgagta gctgccagga actttaagcc cttcatcctc atgctgcgta 1183501 ttaaaaaacg tcagtgtcgg attaacagaa acatccatct cggcagcaat tttcatgtca 1183561 cattgaagcg ccttgaccgc gctttgagaa tgcagatctt ttttgaattc ttcaagatcg 1183621 agacttgtat tttcagcaat ctccaaaagc acgttttcat ccgtaatatt tttctttgaa 1183681 acaaataggc tctcctgcat atttctgaga aattgcatgc cggcttttcg tccttgcagt 1183741 tcggctgctt taaaagcgag agcagccata taaggcgatg aaagcggctg atcctgttcg 1183801 aaccagacat tgccgtcaca tgacatgcca gagcggctcg cgatcttttc ccatgcttct 1183861 gcgagaagat gcttttttcg ctttttattt aaagcggtaa ggcttgcgga agcgataatg 1183921 cgtaaggtga aaaaacgtcc gtatctgatt ttcagctttt tgatgacggg ctctaaggac 1183981 cagcattcag gacataaagg gtctacaaac atataaattt caagcggttt ttttggatga 1184041 ccgtggcaat gggcgaagta tagctcatgc tgatagtttg tcaagatgat cgatcctccg 1184101 cttccgtttg attcaccata tgccttgctg tcaactccag ccggccaaac aaaaactcac 1184161 gaatttcgcc ctccagccct acatggtcca ttgcgtcctt catacagctg agccacgcat 1184221 cagctctctc gtttgtaatt ggaaagggaa gatgccttgc tctgagcata ggatggccgt 1184281 gttcctcagt ataaagagga ggcccgccta aatactgagt taagaattgc ttctgtttcc 1184341 tggcggtttc tgtcaaatcg cttggaaaaa tcggcttcag caaaggatga gacgcgacac 1184401 gctcataaaa agtatcaaca agttgcgata gaagttcctc tccaatcgct tcataaggtg 1184461 cgttaaacga ttgtcccatg ttgactactc ctttaaatat ggctaatagg aatcataaat 1184521 cctattgcaa aaagtaattt tctgtatttc attgtttcat ctagatttat tttagcaaca 1184581 aggcatcatt tctacaaaca aactgccttt tatgcgtttg atgactcatt tcggctgaca 1184641 gccggggttt gtatttcata tcatatcaca taaaaatcag gaatgcgtaa gatttcactt 1184701 cgcaaaaaaa ccagagggaa agagcacctc tggttacgcg taataaactg aagttatttt 1184761 ttttacatag ttttgcgttt cttggaaagg aggaatgcct ccgtatcggt caacattccc 1184821 cggtccggcg ttgtaagccg ctaatgccat agacacattg ccgtcgtatt tatccagcat 1184881 ttgttttaaa tatttcgttc cgccctccac attttgctgc ggatcaagcg gattggaaac 1184941 gccaagtgag cttgctgttg acggcatcag ctgcatgagg cccatcgcac ctgctccgct 1185001 gaccgctttt gcattaaagc ctgattcctg tttgatgacg gcgcggatca gtttttcatc 1185061 aacgccatat ttatcagcgg cttttttaat cgcactgtca atagagaagt ctcccgaacg 1185121 gatctgattt gcttcatgtt tgtttgaagc tgaatctgca acagctgttt cagtgctttc 1185181 tgccgctttt gtgactgaac ctgaattgct gctcgtatat gagttaagcc catacgctga 1185241 aagcagtgac ggcgctgttg tattcgcgct gttcagcatg ctgagcgggc ttggcgatga 1185301 agaaggtgct gattgctgag atgtcagacc gtttgtatat tggctgagca aagaactgaa 1185361 acttgaaagc gggctttccg tattctgagt gtccgagctg ctgcgtgcat tagatatgga 1185421 ctgtaatgcc tgaagctgaa gtaatgctgc ccaattcgtt acattcacga tgtcattcca 1185481 ccttatatag actttcgttt ttcttcataa aaacgcagaa ttttattttt ggtttcgcgc 1185541 tgaggaatgc tgaattgctg aagcagcttt tcgaaggctt gtctgccctc atgccaatcc 1185601 gccgcctcaa attcaatttc atagtcctct ttatttaaat atcggctgtg gtctaaaact 1185661 attaagcctt tttctgtttc tttttccgca cggtttgttg ctaaagatcc aaagtattgt 1185721 atggcatccg tatcgatctg aagcttgtgc agctggtcct tcacagggcc ctcgggaact 1185781 gaaaatccag cgagatctga tacctctgaa agctgctggt gcgtttccag aagccccaca 1185841 tcagccggct cctttaatgt aaggacatac tttccgtttt ttctgcggat acgaagcgca 1185901 gcatgttttt gtttcagcgc gaagctgtct gtatcaaaat aatgattctt ttgatctgta 1185961 aaatcttttt ctgtcagctg gagtgccgat gctatgtttt tgaattcttg tttggtcagc 1186021 atgtttttaa attcgatttc aatctcttgg ctcatgatgc tcttcctttc cgccctgtaa 1186081 atcttatttt tactattatc tctttagatg ttaggtttat caatatcgag ctcgatatga 1186141 taaaatgaat ctgtactttg tttaaaaaag gagagcatta tgcaaaacag aatcgaaatt 1186201 ttgaatgcaa cattatcgga tgatcagctt cgccttgcct gtcagacaga aggaaacgaa 1186261 gcggaacgca agccgtcagg tcaaatgctt gttgattctg accactttgc ttttgtatac 1186321 atacttgaat tagctgattc ttttgaatat gtcattataa aggaacatgt atggccggaa 1186381 ctgaagcagg cccatgcaca aaaaataccg gttgttttag aggcaggaga ccaaacaatt 1186441 gaactggcag gcctgcatga ggagctggaa tatcttttag aaaatataaa agataatgca 1186501 aactatggag aagaaatgga agaaaaagtg aaacgcgtgt ttttatagaa actggttcgg 1186561 aattggggga tgtatgatgg atgacaaaca atgggagcgt tttttagtgc cgtaccgcca 1186621 ggctgtcgaa gagttgaaag tgaagctcaa ggggatccgc acactatatg aatacgagga 1186681 cgaccattca ccgatcgaat ttgtgaccgg acgcgtcaag cctgtggcga gcatacttga 1186741 aaaagcgaga cggaaaagca taccgctgca tgaaattgaa accatgcagg acattgctgg 1186801 ccttagaatc atgtgccaat ttgtcgatga catccaaatc gtaaaagaga tgctttttgc 1186861 cagaaaagat ttcaccgttg tggatcagag ggattatatt gcggaacata aagagagcgg 1186921 ataccgatca taccatcttg ttgtgctgta ccctttgcag acggtatccg gagaaaagca 1186981 tgttctcgta gaaatacaga tccgtacact ggcgatgaat ttttgggcga ccattgaaca 1187041 ttcattgaat tataaataca gcggaaacat tcctgaaaaa gtaaaactaa ggcttcagcg 1187101 cgcttctgaa gcggcttccc ggcttgatga agagatgtcg gagatcaggg gtgaagtaca 1187161 ggaagctcaa gctgcctttt caagaaagaa aaaaggaagc gagcaacaat aggtaaaggg 1187221 gaagaagagc atgaaatttg ccgtatcatc aaaaggagat caagtttctg atacgctgaa 1187281 aagcaaaata caggcgtatt tattggattt tgatatggaa ctggatgaaa atgaaccgga 1187341 aatcgttatt tcagtcggag gcgacggaac gcttttgtat gcttttcaca gatacagcga 1187401 ccgtttggac aaaacagcat ttgtcggcgt tcacacaggt catctgggtt tttatgccga 1187461 ctgggttcct catgaaattg aaaaacttgt tcttgccatc gcgaaaacgc cgtatcatac 1187521 agtcgaatat ccgcttctcg aagtcattgt gacctatcac gaaaacgagc gggaagaaag 1187581 atacttagct ttgaatgaat gtacgattaa aagcatcgaa ggaagccttg ttgctgatgt 1187641 ggaaatcaaa gggcagctct ttgaaacctt ccggggcgac ggcctctgcc tgtcaactcc 1187701 atcaggcagc acagcctaca ataaggcgct gggcggagcg attatccatc cgtctatcag 1187761 ggcgatccag cttgcggaaa tggcttcaat taataaccgc gtgttccgta cggtcgggtc 1187821 acctctgctt ctcccatccc atcatgattg catgattaag ccgagaaacg aagttgactt 1187881 tcaagtgacg attgaccatt taacccttct ccataaggat gtaaagtcga tccgctgcca 1187941 agttgcatcc gaaaaagtgc ggtttgcgag attccgtccg tttccatttt ggaaaagagt 1188001 ccaggattcg tttattggaa aaggtgaata gaaagaggac atatcgtgga gcattttttt 1188061 atcagaaaga acattacttc cgctgaggac gggatgactg taaaagaata tgccggtgaa 1188121 ctgggaattt cgaaacgtct gctgaccgat attaagtttg gcgggggaga cctgcagatt 1188181 aacggtgagc atgtgacggt caaatacgtt ttgaaagagg gagatcttct tatcgtgaag 1188241 tttcctgagg agcaggtgag cgagacgctg ttggcagagc ctgttccgct cgatatcctt 1188301 tatgaggatg aacatgtgct tgtgataaac aagcagccgt atgtgtcatc aatcccttcg 1188361 agagagcacc cctccggcag cattgccaat ggaattattg atcattatca aacaaccgga 1188421 gtgagggcga cagttcatct tgtcacccgg ttagaccggg atacatcagg tatcatgctt 1188481 gttgccaagc atcgatttgc ccactccatt ttatcgtctg cgcaaaaaaa cggccttgtg 1188541 aaacgccggt atgcggcagt ggttcacggg cggatggcac agatggaggg aacagtcgat 1188601 gctccgattg gcagacatcc tgacagtatt attgaacgga cggtaacgcc agacggccag 1188661 aaggctgtta ctcattttta cgtcacatgt gcaaatgatg acatgacctc ggtggcattg 1188721 cagcttgaga ctggacgaac ccatcaaatt cgtgttcata tgagctatct cgggcacccg 1188781 ttgtgcggcg atacactgta cggcggaacg agacaggaaa ttggccggca ggctctgcac 1188841 agcgagcatc tttcgtttat ccatccgctg acacaggaga acatgaggtt tcatgctcca 1188901 ctgcctcagg acatgagcaa actgataaaa ggagagaatc attgattctc tcctttttta 1188961 tatggggcga aatcttgatt cgtcgtaagg cagggagctt ggaacagaga cggtttctat 1189021 ttctggaaag cgaaagcctg tcagttgatt tccgaacacg cagcctgtat caatgttgat 1189081 ggtgcgattg accttccgag gctctttcac aggtgtatga ccgtatacca cccaagcctt 1189141 tccgttatag gctgccgccc aatcacgcct gatgggtctg ccgtccggat atgtttcacc 1189201 cgtcacgtca ccgtaaagca caaagtcctt cactctgcgg gtatatttgc cgatatcgtc 1189261 agctcttatg ccagcatggg cgacaactaa ttctccatta tgtaagatgt cgtaaagcgg 1189321 cgctgtttcg tacagcttca taaactgttc gctgactgat tttttctcat ctttggaaag 1189381 ttcctcaagc tctgccgctg ttgtttcgag accatgcatc acttttaccg gatttccttt 1189441 taagtaacga tataatttat tgcaatggtt tcccgggaca taacgcacag cgcctttttc 1189501 gtaagcgccg gctacaaatc ggatgacctc tatcgatttg ggccctctgt cagttaaatc 1189561 tccggcaaaa acaagcaccc tgccttcttc atggacaggt actccatttt tgattgtata 1189621 gccaagcttt tggattaatg cagtcatttc gtcatagcag ccatgaatat cgctgatgat 1189681 atcgtaagcc atgcggtctc ctccttaccg attgttttat ttattatgaa gcaaagtgtt 1189741 gtgagtcatc acaagctttt atgtgcaaat tatagaagaa gaatcatttt ctaaacagga 1189801 ttaagacctt atcactttat ttttcatcat cacccttgtt aaaatcgcgt tatgtttttt 1189861 aaaaatgagg ttttgttctc tgagtgagaa ctagcataac cctgacttaa aaaggaggtt 1189921 ctgattatgg cgcatacatc tgtcgcatct ttagttgttg tacttatcgt tgcatttttg 1189981 acacccatcc ttttgcatcg gtttaaactc agcatcccgg ttgttgttgc tgaaatcatt 1190041 atggggctga taattgggaa aagcggcctt aatttagttg tggagggtga cacctggctc 1190101 cagacactct ctatgctcgg atttatcttt ttaatgtttt taagcgggct tgaaattgat 1190161 ttttcgtcgt ttgagaaagg aaagaaaaag cagttcctgc cgaatggcaa ggaagcgccg 1190221 aatacgtttg ctgcggcatc tgttattttc gtcggtattt ttattttatc attgctcttg 1190281 tcctatgggt tcgtcttggc cggatttatc caaaatgcat ttttgatgac cctgattatt 1190341 tcaacgattt cattaggcgt tgtcgttcca acattaaaag aagaacggat catgaattcg 1190401 aatatcgggc agattatttt gcttgttgct gttattgctg atttggccac gatgattctt 1190461 cttgctgttt tttcttcttt atacggagag gacagcggaa acatgtggct cctgatgatt 1190521 ctgtttgcgg ccggagtggt gctttacttt ttcggccggg tcttcaaaca tcgctctttt 1190581 gttcaatcca tgtcaaaagg gacgatccag atcgggacgc gtgccatttt tacgttaatc 1190641 attgtactcg ttgccctgtc tgaatcactt ggggcggaaa atattctcgg cgctttctta 1190701 gcgggggttc ttgtttccct gctttcgcca aacaaagaac ttgttcagca gctggactca 1190761 ttcggttatg ggttcttaat accgattttc ttcgtgatgg tcggtgtgaa gcttgatatt 1190821 tggactcttt tccaggataa aacaatttta atcatgattc cgctcctgct gcttgcgctg 1190881 ttagtcagca aaatcattcc tgtcatgtac ttaaagaagt ggtatgataa ccgaaccatt 1190941 ttcgcgtctg gtttcctgct gacatcaacg ctttcgctcg tgattgctgc tgcaacaatc 1191001 ggccagcagc ttcacgtgat cagtacaaat atgtcaggag cgctaatttt agtagccgtc 1191061 attgcaagta tttttacgcc gatctgtttt aaaaaattat acaaacggga agagcagccg 1191121 gaggagaaaa agacgattac gttcattggc gccaatcaaa tgactttgcc tgtcacactc 1191181 gaattgccag aggaagagta tgacgtgcgt gttgtacacg tctaccaaga gaatgcggag 1191241 gaaaagctgt cagaatcagt gtttgctgtt gaaacaattt ctgactatga acacgagacg 1191301 cttgaatcac tcggcatttt tgaaacggat atcctcgttg tggcgacagg aaatgaagat 1191361 atgaatgcag acattgcatt acttgcaaaa gataaaggca cagaaagagt cattgcaagc 1191421 gtaggatcac cggagcatga agcagctctg aaggagcagg gaatcagcat cttttctatt 1191481 ctgctgtcga caaaaacgct gcttcgcgca ctgattgaag cgcctggcgt catgaagctg 1191541 ctcacgaacc aagagtcttc gctgtatcaa attaatatgg agaacagtaa atatgatggt 1191601 gtcattttac gggaattccc tttaacaggt gacgtcatct ttgtcaggat cttcagaggt 1191661 gtggacagca tcgttcctca tggggatacg aggctgaaac ttggagaccg tttaattgtc 1191721 accggatctc gggggtacgt aacggatctt aagaaaacat tggaaggata aatcttgacc 1191781 aaataaggat tcgtgttaat atagaggtgc agaacaattc aatatgtatt cgtttaacca 1191841 ctaggggtgt ccttcataag ggctgagata aaagtgtgac ttttagaccc tcataacttg 1191901 aacaggttca gacctgcgta gggaagtgga gcggtatttg tgttatttta ctatgccaat 1191961 tccaaaccac ttttccttgc gggaaagtgg tttttttatt ttcagagggg gaatgatttg 1192021 tgaagttttc agaagaatgc cgcagtgcag ccgcagaatg gtgggagggg agctttgtcc 1192081 atccgttcgt tcaaggaatc ggtgacggaa cgcttccgat tgaccgtttt aaatactacg 1192141 tacttcagga ttcctattat ttaacgcatt ttgcaaaggt gcagtcattt ggtgccgctt 1192201 atgcgaagga tctttataca acggggcgga tggcaagcca tgcccaaggt acatatgagg 1192261 cggaaatggc gcttcatcgc gagtttgccg agctgttgga aatcagcgag gaagagcgta 1192321 aggcgtttaa gccgtctcct acggcgtact cttatacatc ccatatgtac cgttcggttt 1192381 tgagcgggaa tttcgcagaa atcttagcgg ccctgctgcc atgctattgg ctctattacg 1192441 aggttggtga gaaattgctg cattgtgatc cggggcatcc aatttatcag aagtggattg 1192501 gcacatatgg cggtgattgg tttagacaac aggtcgagga gcaaatcaac cgctttgatg 1192561 agctggcgga aaacagcacg gaggaagtgc gtgccaagat gaaagagaat tttgtcatct 1192621 ccagctacta tgaatatcaa ttttggggaa tggcctatcg aaaagaaggc tggtctgaca 1192681 gcgccataaa agaggtggag gaatgtggag cttcacgcca taacggatga cagcaagccg 1192741 gtagaagagc tagcgagaat catcattacg attcagaatg aagttgattt tattcacatt 1192801 cgggaacgct caaaatcggc ggcggatatt ttgaaactgc tcgatcttat ttttgaaggc 1192861 ggtatagata aacgaaaatt ggtgatgaac gggcgcgtgg atattgcact tttctctact 1192921 attcaccgcg tgcagctgcc aagcggcagc ttttcaccga agcagatcag agccagattt 1192981 ccacaccttc atatcgggag gtcggtgcat tcactggagg aagcggttca agcagaaaag 1193041 gaagacgcgg actacgtgct gttcggccat gtgtttgaaa cggattgcaa aaagggtctt 1193101 gaaggcagag gagtatcttt gctgtcagat atcaaacagc ggatttccat cccggttata 1193161 gccatcgggg ggatgacgcc ggacaggtta agagacgtaa aacaagcagg ggcagacggc 1193221 attgctgtta tgtcaggaat tttctcttcc gctgaacctt tggaagcagc cagacgatat 1193281 tcccgcaagc taaaggagat gcgctatgaa aaggcattat gaagcagtgg tgattggagg 1193341 cggaattatc ggttccgcaa ttgcttatta tttggcaaag gaaaacaaaa acaccgcatt 1193401 gtttgaaagc ggaacaatgg gcggcagaac gacaagtgcc gctgccggaa tgctgggcgc 1193461 ccatgccgaa tgcgaggaac gtgacgcgtt ttttgatttc gctatgcaca gtcagcgtct 1193521 gtacaaaggt cttggagaag agctttatgc attatccggt gtggatatca ggcagcataa 1193581 cggcggtatg tttaagcttg cattttctga agaagatgtg ctgcagctga gacagatgga 1193641 cgatttggac tctgtcagct ggtattcaaa agaagaggtg ttagaaaaag agccgtatgc 1193701 gtctggtgac atctttggtg catcttttat tcaggatgat gtgcatgtgg agccttattt 1193761 tgtttgcaag gcatatgtga aagcagcaaa aatgcttggg gcggagattt ttgagcatac 1193821 gcccgtcctg catgtcgaac gtgacggtga agccctgttc atcaagaccc ctagcggaga 1193881 cgtatgggct aatcatgttg tcgttgccag cggggtgtgg agcggaatgt tttttaaaca 1193941 gcttggactg aacaatgctt ttctccctgt aaaaggggag tgcctgtccg tttggaatga 1194001 tgatatcccg ctgacaaaaa cgctttacca tgatcactgc tatatcgtac cgagaaaaag 1194061 cggaagactg gttgtcggcg cgacaatgaa gccgggggac tggagtgaaa caccggatct 1194121 tggcggattg gaatctgtta tgaaaaaagc aaaaacgatg ctgccggcta tacagaatat 1194181 gaaggtggat cgtttttggg cgggactccg tccgggaaca aaggatggaa aaccgtacat 1194241 cggcagacat cctgaggaca gccgtatttt atttgcggct ggccatttca gaaacgggat 1194301 cctgcttgct cccgcaacgg gcgctttgat cagtgatctc atcatgaata aagaggtcaa 1194361 ccaagactgg ctgcacgcat tccgaattga tcgcaaggag gcggttcaga tatgatgcta 1194421 cagctgaacg gtaaagacgt gaagtggaaa aaagacacag gtacaattca agacctgctg 1194481 gcgtcgtatc agcttgaaaa taaaatcgtt atcgtggaaa gaaataaaga aataatcggg 1194541 aaagaacgct atcacgaggt tgagctttgt gatcgtgatg tcattgaaat tgtccatttt 1194601 gtaggaggcg gatgagcatg ttaacaattg gcggaaaatc atttcaatca agattgctgc 1194661 tgggcacggg gaaataccca tcgtttgaca ttcaaaagga agcagtagct gtttctgagt 1194721 ctgatatttt aacatttgct gtaaggagaa tgaacatttt tgaagcatct cagccgaatt 1194781 ttctggaaca gcttgattta tccaaatata cgcttttgcc gaatacagcg ggcgccagta 1194841 ctgctgaaga agcggttcgg attgcaaggc tggcgaaagc ttcaggcctt tgtgacatga 1194901 ttaaagttga agtcatcgga tgcagccgtt ccttgctgcc tgaccctgtt gagacattaa 1194961 aagcgtctga acagcttctt gaagaaggct ttattgtgct cccgtacacg tcggatgacg 1195021 ttgtgctggc gagaaagctg gaagagctcg gcgttcatgc catcatgccg ggtgcatctc 1195081 cgattggatc aggacaagga atcttaaatc ctttgaatct gtcgtttatt attgaacagg 1195141 cgaaagtacc ggtcatcgtg gatgcgggaa tcggctcgcc taaagatgcg gcatacgcaa 1195201 tggagcttgg agcggatggc gtactgctca atacggctgt atctggcgct gacgatcccg 1195261 tgaaaatggc tcgtgccatg aagctcgcag tggaagcagg gcgcctttct tatgaggcgg 1195321 gccgaatccc gcttaagcaa tacggaacgg caagcagtcc gggagaaggt cttcctgtat 1195381 gacaggcagg tattcaaggc aggagctgtt tgctccgatc ggcccatccg gccagaaaaa 1195441 attgaaagaa gcgcgcgccg tgattatcgg cgccggcgcg ctcggaacag ccagtgcaga 1195501 aatgctggtg agagcgggag tcggctctgt gaaaattgcc gacagagatt atgttgaatg 1195561 gagcaacctc cagcgccagc agctttatac agaagatgat gtcaaaaaag aaatgccgaa 1195621 agcagccgct gcggagcgcc gtctccgttc gattaacagc gatgttgatg tgaccggcct 1195681 tgtcatggat gtgacagcag aaaatatctt cgagctgatt agggatgcat cgattattgt 1195741 ggatgcggct gataattttg aaacccgcct gatcgtaaat gatgctgcgg taaaggaagg 1195801 gattcctttt ctttacggtg cctgtgtagg gagctacggt cttaccttta ccgtggtgcc 1195861 gggttctact ccttgcctgc attgcttgct cgatgcactt ccgattggcg gagcaacatg 1195921 tgacacagct ggcatcatca gtccggctgt tttgcaggta gcagtctttc aggtaacaga 1195981 tgcactgaaa ctgctgacgg gagaggagtg cgagccggtg ctgcgctcct ttgatttgtg 1196041 gaaaaacgag cggtcagaag tgagagcggc cagtctcaaa catgacgcat gcccaagctg 1196101 cggcacaaag gattttccgt ttttgtctta tgaaaatcaa acaaaagcgg ctgtattgtg 1196161 cggcaggaac acggtgcaga tcagatcatc tattacgaaa gaagcggatc ttgaagcgct 1196221 tgccggtcag ctgaggcagg ccgggcttga agtagctgcg aacccgtatt taatttcctg 1196281 ccgctcggat gatatgaaaa tggtgctgtt ccgggacggc agagctttga tccatggaac 1196341 aaatgatatt gcccgggcaa aatccattta tcataaatgg attgggtaat aaaaggagtg 1196401 tagtgtaatg agtatatata aagcattgac aatcgccgga tcagattcag gcggcggcgc 1196461 agggatacag gctgatatta aaacctttca agagcttgat gtattcggaa tgtctgcgat 1196521 tacggcggta accgctcaaa atacgcttgg cgttcacggg gtgcatccgc tgactgtaga 1196581 gacgttgaga cagcaaattg acgctgttgc tgaggatttg agaccggatg cagttaagac 1196641 gggaatgctc tggaatgccg acatgattga agaagtggca agaaaaattg acgagtacgg 1196701 attcaatcgt gtaattgttg atccggttat gatcgcaaag ggcggggcat ccttgctgcg 1196761 tgatgagtca gttgccacct taaaggagtt gctcattcca agaagctacg cgattacgcc 1196821 gaatgtcccg gaagcagaaa cgctgacagg aatgacaatc agctcgctgg atgaccggaa 1196881 aaaagcagcg gagcagctcg tcaagatggg tgcgcagcat gtcattatca aaggcgggca 1196941 ccagcctgag gacaatcaca ttactgacct tctttttgat ggcagcatgt ttatgcaaat 1197001 cacccatcct tatatcaata cgaagcatac gcatggcaca ggctgcacct ttgctgcggc 1197061 tttaacggcc caaacggcta aaggagacag catccatcag gcatttgagg ttgcggccaa 1197121 ctttgtccgt gaagcggtgg aaaatacgct cggcatcgga tcgggacacg ggccgacaaa 1197181 ccatttcgct tttaaacgaa acagcttaaa tacaagccga tgagatcacc agctgatggt 1197241 gatctctttt gcgtttgcta cggtatgcgc ttttcatctg gacaaggtta tgatatgata 1197301 ggaattaaga tcaggtacta atactatgtc tttattaaat ataggaggct ttatacatat 1197361 gaatttttca cttgaaggcc gtaacattgt tgtgatgggg gtagccaaca aacgcagcat 1197421 cgcctggggc attgcgcgtt ctttacatga agcgggtgca cgtttgattt tcacatacgc 1197481 tggtgaacgc ctggagaaat ccgttcacga gcttgccgga acattagacc gcaacgattc 1197541 catcatcctc ccttgcgatg ttacaaacga cgcagaaatc gaaacttgct tcgcaagcat 1197601 taaggagcag gtcggtgtaa tccacggtat cgcgcattgt atcgcgtttg ccaacaaaga 1197661 agagcttgtc ggcgagtact taaacacaaa tcgtgacggc ttccttttgg ctcataacat 1197721 cagctcatat tctctgactg ctgttgtcaa agcggcacgt ccgatgatga ctgaaggcgg 1197781 aagcattgtc actttgacgt accttggcgg agagcttgtg atgccaaact acaacgtcat 1197841 gggtgtagca aaagcttctc ttgatgcaag tgtgaaatat ttagctgctg acttaggaaa 1197901 agaaaatatc cgcgtcaaca gcatttctgc cggcccgatc agaacattat ctgctaaagg 1197961 catcagcgat ttcaactcta tcttaaaaga catcgaagag cgtgcaccgc ttcgccgcac 1198021 gacaacacct gaagaagtgg gcgatacagc tgcgttcttg ttcagcgata tgtcccgcgg 1198081 gattacaggt gaaaatcttc acgttgattc tggtttccat atcactgccc gctaagcagg 1198141 atctatatca agcaatcccg aatagggatt gcttttttat ttcttctgat tttcagcttt 1198201 ctgtcatata gatagaatat gacacaatcg gagggatgaa gatgtctaat aagaaaagaa 1198261 acgcggataa aaaaccgctc atgtatattg ttcagccgga ttatgcagaa actacaaggt 1198321 catccatgca ggagattgtc atcaaaagaa aggccgacaa acccgctccg ccaaaagctg 1198381 aggaaaagcc ggcttaccat gagaagcagc aggaggaagc cgtggcacag gatgtcctgc 1198441 aagaagacca aaagcctgca gccgaaccag tgagtcagca aacacaagag gcgagagagc 1198501 cagagaacat aaaaagccaa gaggaacaga aggcagagcc gcaggccgta gaagaaaccg 1198561 ttgaacacga gcccccgaaa gcagaaaaaa aggaagagcc tgcacttgag gcccggaagc 1198621 ctgagaaaga accggaagct gtccatagtg ctgataaagc ggaggaaaaa gcaccgccgg 1198681 cacgaaaagt gaaaaaaccg atgagcaaga tgacgatcca cgaaaaaatt gattttttaa 1198741 caaagctgcc tcataacatg ccgagagcgc tttgtttgat tgaagccaat ggaagaacgt 1198801 acaggggcgt gattgtcgga agaagaaatg attccgtcct gcttcgaaca accggaaacg 1198861 gagccccaac cgaactggca atcgatgata ttacctcttt gcacccgctc ggtttttaac 1198921 gaaaaagaaa aaagctgccc ggctgatgtt gccggacagc tttttttaca tagagaaaag 1198981 cctgcaggcc tgcaagcttt tccagcttat gattaatgat gatgtgtacg attgattaat 1199041 cgaggattta agcagttgat tgcgcagaag cagtctaagt caacttcaat acagtagttc 1199101 gttttttcga gtcggaacac ttcacacacc gtatctttat cggtgaagtc caaaatgtgt 1199161 ttgtgttcgt caaatgcgat taataatgac agtgttgcac agcttccatg cactctttcg 1199221 accctgaaaa atactgtatt aaagcaaggg ccgttatcga gttcgccgac atttccgaag 1199281 gcgactaatg gcgttgattt tgatgtaaat attgcaaaag gcactgtgtc gcctaacgaa 1199341 tggcttacag ataaaagctt agagtggcag ccggtcgggc agtcttcttc aacagcgttt 1199401 tgcagatctt caatattttc tacagcttca cgcacgcagc ttgatgtttt ctggctcata 1199461 ttatccctcc tgccttataa atttgagact ggcgaaatga tggagagtca gctgcctcac 1199521 gctggaagca gctgaatgat ttgcacctgt aatagagttt ggaaggggat tcctctttac 1199581 aagtgtttat ccattgtgat gatgcttttt atctttgtga ggcgatgttc tgtcaactag 1199641 ctctggtgac aggcactgaa tcgcgcagaa gcatccgaga tccacttcaa tgcagaaatc 1199701 tgttttttct agcccgaaga aatccgggtc gcaagggtgg caaacactta aggtatcgcc 1199761 tttgacatcg accgggcgta aaatagacag tgttgcacag caatcgcata atttttcgac 1199821 gcggaagaaa atggattcaa agcattgcat atcatccaca aatcccccta cgtttccgaa 1199881 tgtggagaac aatccgcctt ttttatcaaa aacgagaaac ggaattgtgt cttttccagc 1199941 aatcgtaggg tttaaaaggt tggtatagca gccagtcgga cactgttctt caactgcctc 1200001 ctgctctgct aaaatctttt ccactgcatc gcatacacag ttctcatgcc ggccatgggt 1200061 ttttccgcag ctcattgatt tcagctcctt ctttataggg tatttgactt tagtccttaa 1200121 caacatatgt acccgtgccc cacttggtgt gggtgaacgt ctatatattc atcatatgct 1200181 tggaaaataa gaaaaagcag agcgttttta gctctgcttt taggtcctag aggacaagag 1200241 tgataactag gatggctacg agtgtatttg ttgctgtaga aataagggtt gcgatatcgg 1200301 catctactgt tgtgacgttt acgccgcggg aacattcgat gagaagtttt tggcggttta 1200361 cttgtttgtt agctgtaagc tgtaacaaat cttgtgcgac taattcggca attacgccgt 1200421 ctgcaattga tgtcagagtt gccgttacga cagcggcatt aagtgctgtt acaactgatg 1200481 ttacggcttg aacgtctgta gatgtaacat tgatgtcaca agaatctcta ataataatcg 1200541 tttcatctga aacttgtttg ttgagatttg cttgagctag atcttggtcg atgaaggcgt 1200601 tgtcgttgcc aaaaaaacca ttgccattac agcaaacgtc gcaatgacat tttctttcgt 1200661 gtttttcttt atctttctct ttgtcatcta acggatggtc acagtcagga tcaagtgcaa 1200721 cccaagaata tggtctgctt tccatatcta ttcctccttt tcttttactg ttattaaatg 1200781 agcgagcctc ttattttgac tgagtcatat atcctgatga agaaccctat tttttatgat 1200841 tggctaattg ttatcgtttt tccgtctttg tctgatctgt tcaatgagct gctctctgcg 1200901 gcttaacggt tttgtgttct tttgctcttg tgcggctgct tcttcttttt tcttcttttg 1200961 gttttctatt agcgcttgtg atttagcttg taagtctttt acaagattta agagcatttc 1201021 tttttcttcg tctgatactt ttttcatttt gtcttttgtg accccatgtt tagaaaatat 1201081 attttggacc agcattttcg tcattggatc aacttctgga agctttgcaa gctcttcttt 1201141 gaatttatcg ttatctgaca tttgttttca cctcgtcttt taagtttgtg aaaagaaagg 1201201 gttaaaggac gtcaagttca ctaagaatgc tgtttaacac ctgaagcaag atttgtacaa 1201261 aggttattat ctcgtcggca gacaaagtaa ttttgatgtt gcggctgttg ataattttaa 1201321 tgatggttct ttttttgatt tgggagctat cgagaataag aatttcactt gccactgcgt 1201381 cagccaaatc ctcgtcggcg atgacgagct gagtcgccac gataatcatg gttgtcacaa 1201441 aggcttgtat agaaagggca gctgttatat gtgacgtgtc aattgtgata ttttcgcaat 1201501 caatcacttc gatctgctgt tcgaattcgc ttgataattg ctcaaatatt gcagggtgca 1201561 gggattcgac tttttcttca aatgacataa ccttcactcc tttcttatcc atactctata 1201621 taatgcaaat ggggtgcaga gcggaataat aaaaataacc aattttctgc cggacaagat 1201681 acaattcatg aagaataggg ttttggcata tatgtgaagg gatcatgatt ggcaaaggag 1201741 tgaacgagtg gttataaatg ggctgacaat tgttcttcta tcgcttgcgg tctttcggct 1201801 cgcccgcctg ctggtgtttg acacgattat ggcgccgctt cgcagtctgt ttcatgaaga 1201861 gaaggaagaa aaggatgcgg acgggaacat tgaaacctat atcgtgatta agggaaccgg 1201921 tgtcagggcg tttattggtg aattgctgag ctgctattgg tgcacaggcg tgtggtgtgc 1201981 cggctttttg attttatgcc aggcggtgat cccgcaagcg gcgcagtggc tgattttact 1202041 tttggcgatc gccggccttg ccggcattat agaaacgctc gtatcaaaat ggctgcaaga 1202101 ataaggcgtt accaccagca actttctgtc agaatacgca taaagtagca tatatgacat 1202161 aaggaaagga aggggacaaa aatgaatcag catcataaac cttcccaaaa atctccatat 1202221 acagattcat cgtatcaatc aaaaaagata aaaaagaaag gctgcgggtg cggaaataaa 1202281 aagaaaaagc ctcaatagcc tggcaaagaa accggagaac tccggttttt tgttttttta 1202341 acgaggcggt ctcgctcagc atatatcata agcgggggga taaaagtgaa tgagtttgaa 1202401 aaatggatag aaggaagata tgaaccacat gaacaaaagc aaaaagagca tgaagacacg 1202461 atgggcagta tcagaaaaga cttggatgca tttgataaag ccggtctgga atttgaagat 1202521 gagattgaag agctggctga aaaaacggag gccttactta aaaaacatca agctcaatat 1202581 gatcaatcgt aaatccgcaa acgccctatg cgaatatcca agccgatccc agcagctcac 1202641 atagtgtata gagagtaaag gaggtgctta tctatgggct ttggatacgg attcggcggc 1202701 ggctacggcg gcggctgtta tggcggttat gctggcggtt acggcggcgg ctatggttca 1202761 acatttgttt tgttggtcgt attattcatt ctcctcatca tcgtaggtgc atctttcttt 1202821 taagatgtat tgaggaagta cgggttataa cccgtacttc cttgccttgt gtttattttt 1202881 aaaaatgttg gaaaagcaca ttgtattatg tgcattcata caataccgta ttactccgcc 1202941 aaaaggaggc gcattatgga taatcaattt tttaagaaca tcgaaaagaa aacaggtgtg 1203001 aagatgcagg atgtaatgaa tcttgccgga tcactccaaa acgctaattt taaagatgaa 1203061 aatacagtgc gcagtgtgat taaccgcgta gcgcagatgg caaacagacg cgtgccaaaa 1203121 gaattagaag ataaaattgt ggaatctatt acaagcggaa aagaaaagct tgattttggc 1203181 acgatttcta aaatgatgga taataaataa gtggatggcc tggctgactc actgcagcgg 1203241 gccttttttt acagtaaaaa cccggcagta atctgccggg ctgttaatga tgcaagggct 1203301 gtcttgcttt ctgtagcagg ggatacaaaa atcttgagcg gttggctgtt ttgccgcgcc 1203361 tgttagcagg gcaagacaaa tataaatgct gtttcgcccg ggtcatggct acatataaaa 1203421 ggcgtctttc ctcctcaaga gcggcctcgt ctccttttct tgccgtttct aatgagaaat 1203481 cgtgcggaat cgagccatct acagtgccta acacgtagac tgttttgaat tcaaggcctt 1203541 ttgaccggtg aatggtcatc agctgaacgc catgttcatc cgttctgttt ttctcagcgg 1203601 ccctcatatg gtctacgtgg gcaagaaagt caggaatcgt tttgaacttc ttggcgacaa 1203661 ccttgatgtc gcgcaggtca tcagagcctt tttccagctt gttgccctca ttgccccgct 1203721 tttttaaata ctcggagaag cccatttttc cttctgcaaa ggtgatggct tctacgggtt 1203781 tcattgtgcg gaggcttgca aaaaacggta cgattttctt gattttgtcc agctggaatg 1203841 gcttcagatc aggcaatttg gccagcgctt tgatcatggt acagtcctct gtaatcgaga 1203901 gcgccttcag cgtattcaaa gcggactgtt ttaaaaacaa ggcgggaagc aagtgtttaa 1203961 tcgcctcggt gtcatcctca ttttggctgg cgtacaagta ggcgagaatc tggcggacga 1204021 tccgtctgct gtaaaacgat tggacgccgc ggtcagctgt atacggaatt gacgattgat 1204081 gaagcctttc atatatagca cggcctccgc tgtttgtgcg gtaaagaacc gcaaagtctt 1204141 ctggactggc tccattttga attttttctt tgatatcgga aacgaccatt gtggcttctt 1204201 cctcttcatc ataaggataa aacagcacag ggacctgaat gtcatcgcgg gccgcttcaa 1204261 gcgttttggc atatctgttt ttgttctttt tcacaacgat atcagcacta gagacgatcg 1204321 ggtgcgtaga cctgtagttc gcagttaaat agatcgtctt cgctcccgga taatcctttt 1204381 gaaaatcaag aatgaaagac ggattgcttc cgcgaaacgc gtagatggac tggtcatcgt 1204441 ctccgacaca gcacaggttt tgctccgggc tggcgagcat ttgcatgatt ttgtattgaa 1204501 ccggattaat gtcctgaaac tcatcaatta agatatacgt aaaccgagat tgatattgtt 1204561 ccagaaggtc aggccgctcg ataaacaatt catagcaggc tgaagccatg tcatcaaaat 1204621 caaattggct gtgttctttt ttctggcgtt cataatgttc atataaacga taaacttgtt 1204681 tttcccactc atcttttaga gggatgcgtt catttgggac ataagtgttt ttccaaaaac 1204741 cgatctgctg cagggcttgg tcaactgggg attctttctc atcgatgcct tcttcataga 1204801 gtgctttttt gatatattgt tcccgctgcc actccatttt cagcagatgc tcaccgttcc 1204861 atttagcaga attagagtga tacaagatct tataaaacag actgtggaat gttcctgtca 1204921 caattcttct gacttttgcc ggctgtaatc cgtactggtt cgccatacgc tctttcattt 1204981 cagcgacagc ttttgttgta aaggtgacaa gcagcatatt ttcaggcggt atgcctaagt 1205041 gttcgatcat gtgggcggca cgggctgtca gtacccgtgt ttttccgctc cccgcacctg 1205101 caagcacgag gagcgggccc tctgtttccg tgacagcttt cagctgatcc gtgtttaaac 1205161 cgacagacgg aaaaaggctc gtatcgggtt ctattgtttt tggcacaaat ggtgttcctg 1205221 gtttaatgct tctaggacgg tgccattctg taacagctgg ggacgggtca gcggcgatcg 1205281 cttttccctt gggtaaacga atgacaccag attcctgatc atcttctttt ttcccctctt 1205341 tagagggctt cggttcgcac gcctcctcac atgccggaaa atcgcctggc tggcgatgga 1205401 taaactctgg cggatcggcg atgttaagcc gtaacaaaac gggctttccg caatgagaac 1205461 aaaataaatg tccttttatt ccctcttcaa agaggaattg ataatgttct ctcgaatatg 1205521 tatgtaaatg tatgattcta tcattcagtc gggcgcattt caaaaagggg tcctcccaat 1205581 caaaaggtgt tcattacaga caatgactat catatcaaaa gaaatgtgtt tcaaaaagta 1205641 agtttaaggg aaaagagaca gcagaggggt gggtattgta tgatatatgc aggtcaaatt 1205701 cagaaccagc aatacgctca atatgctaat agaacgattg gacataagca ggattatgcc 1205761 ggaaccgaaa aaatcagcta tgtcccgttt cagcgggtat acaaagaact ggaaaagcag 1205821 caggagaatc aaacggcagc tgaaagaaaa gtaaacgaga tgaaacgtaa gcgctctctt 1205881 tataagagat tgcgagaaaa aggaatgggg acatatatta atcgatatgt ataaaaaacc 1205941 gttcatacca gagaacggtt tttttatatg cagtaaaaat ccggatctca aaagatccgg 1206001 atgcgttcag tccttcatca tttgtaagtg cggaatgccg gcatcgagga attctttttc 1206061 agaaagcacg cgatacccgt gtttcttgta aaacggcaca gcctgtgttt gcgcgtttaa 1206121 aatgaaaccg gaagcgcctc cgtctgccgc ggctttttcg agcgctttca taatgatgcc 1206181 gccgacaccg gctgagcggt ggcttttcag tacgcaaatc cgctctaact tgccgtagcc 1206241 gtccttcatg cgccatcttc cggcaccgac aggcttttca ccgtcataca cgacgatatg 1206301 ctctgactca ttttcaagtt cgtcaatttc ttcttcagca ggcacgtttt gttctttgac 1206361 aaagacttct tctcttacat agaatgcatc tttcagttgt tcttcatttt ttgcgataac 1206421 tgctttcaaa cattattctc ctctgcctag caagaaggtt tcatatactg tccacgatcc 1206481 gttttccaac tggtagagca agtggaaacg gtcaacgatt tcttcatgcg acacttcctg 1206541 catttttaat tgtcccagca catctgaatg ctcatcgtcg gaaagatttt ggccgaccgt 1206601 cacatgcgga acgaaattat attcctgttc tcctgccaac acaccggtgt atagcttttc 1206661 attgagtgtt tttaactctt ccgtcggttc tgctttgatg taaatgacat tattgacagg 1206721 cgcaaatgag ctgtattttg tcattttgag aacgagtggg tgggactctt ttgcgatgtt 1206781 tcttaaatgt gatacgagct gatccgcttt ctcctccgcg cattcaaagg atgctctcag 1206841 cgtcaaatga ggcgggatta gagagtagct tgggtcatag cgctttctgt aagagtttgc 1206901 aaggtcttgg agcttttttg atggaaataa aacgattccg tatttcatat tatgtccctc 1206961 ctggaaataa agtatgatag agtgttaaag catttttttc agcgccgggg tgatgagcgg 1207021 ctgccagtat gtccatttgt ggtctccgtc aaatggctcg aaatcataat cggaaagctt 1207081 tttctccagc agctgtttca gctcccggtt cggttctgta aagtccagaa tgttcccgtc 1207141 tgtcgtgtgg acgtcagttt cttttgttcc gatttggtga taaatagaga ggtgtttgat 1207201 atcgtctgac tgttttacgg cttctagtac gtgtttgtca acatagggag actgcatgat 1207261 gatgttgcca aacatattcg gataatcaag cgctgtcata agtgacacgg ttgctccgag 1207321 cgaatcaccg atcagcgttc ggccgtaacc gatctgatag gttggatact catcatctgc 1207381 aaaaggaacg agctcatggg cgatgaaccg tttataagcc gaaaattttg aaccctccgg 1207441 atgataagtg tttctgcgct cttttacatc cttataggga acaccgataa taatgctccg 1207501 gtctatttcg cgtttcgaca gcaattcctc aacctgtctg ccgattctcc ccagcctgaa 1207561 ataatcgtgg ccgtcctgcg cgataatgac atggtattta taaagcgggg agtagttgga 1207621 cggcagataa acaagcaagg tcatttcctc gttaagctct tttgaaaaga atttcttttc 1207681 ttgcactgtg ccgtttttcg gtgccataaa aacattcctc caggacatca ctatactttc 1207741 ttgcattttc aattattgta ccatgaatta ttagaaattt ctctctttaa acggttcggc 1207801 acacgaagaa aaaagtgttg aaataaactg tgaattgcgc taatataaaa caatcagaaa 1207861 attgaaatcg atatttctta tcgtgagagg tggagggact ggcccttaga aacctcagca 1207921 accggcttgt tttgcatttg caaagcgcca aggtgctaaa tccagcaagc gttttttatg 1207981 cttggaagat aagaagaagc gttaaacccc ttcttcttat gaagaagggg tttttatttt 1208041 gaaaagggaa ggtgtcagct atatgtcaca gcacgttgaa acgaaattag ctcaaattgg 1208101 gaaccgtagc gatgaagtca cgggaacagt gagtgctcct atctatttat caacagcata 1208161 ccgccacaga gggatcggag aatctaccgg atttgattat gtccgcacaa aaaatccgac 1208221 acgccagctt gttgaggacg cgatcgctaa cttagaaaac ggcgcgagag ggcttgcctt 1208281 tagttcggga atggctgcta tccaaacgat tatggcgctg tttaaaagcg gagatgaact 1208341 gatcgtttca tcggacctat atggcggcac gtaccgttta tttgaaaatg aatggaaaaa 1208401 atacggattg acttttcatt atgatgattt cagcgatgag gactgtttac gctctaagat 1208461 tacgccgaat acaaaagcgg tgtttgtgga aacgccgaca aaccccctca tgcaggaggc 1208521 ggacattgaa catattgccc ggattacaaa ggagcacggt cttctgctga tcgtagataa 1208581 tacattttat acaccggtct tgcagcggcc gcttgagctg ggagctgaca ttgtcattca 1208641 cagcgcaacc aagtatttag gcgggcataa cgatctgctt gctggacttg tcgtggtgaa 1208701 ggatgagcgg ctcggagagg aaatgtttca gcatcaaaat gcaatcggcg ccgtcctgcc 1208761 gccatttgat tcgtggcttc tgatgagagg aatgaagacg ctgagcctca gaatgcgcca 1208821 gcatcaggca aacgcgcagg agcttgcggc gtttttagaa gagcaggaag aaatttcgga 1208881 tgtgctgtat cccggaaaag gcggcatgct gtccttccgt ctgcaaaaag aagaatgggt 1208941 caatccgttt ttaaaagcac tgaagaccat ttgttttgca gaaagcctcg gcggggtgga 1209001 aagctttatt acataccctg cgacccagac gcacatggat attcctgaag agatccgcat 1209061 cgcaaacggg gtgtgcaatc ggttgctgcg cttttctgtc ggtattgaac atgcggaaga 1209121 tttaaaagag gatctaaaac aggcattatg tcaggtcaaa gagggagctg tttcatttga 1209181 gtaaacacaa ttggacgctg gaaacccagc tcgtgcacaa tccatttaaa acagacggcg 1209241 gaaccggggc agtcagtgta ccgattcagc acgcctcgac ttttcaccaa tcttcatttg 1209301 aagagttcgg ggcatatgat tacagccgct ctggcacgcc gacaagaaca gctctcgaag 1209361 aaacaattgc cgcactggaa ggcggaacaa gaggatttgc tttcagttca ggcatggctg 1209421 ccatctcaac agcattttta ctgctgtcac agggtgatca cgttcttgtg acagaagatg 1209481 tatacggcgg aaccttccgt atggtgacag aggtgctgac ccggtttggc attgagcata 1209541 cgtttgtcga catgacggat cgtaatgaag tggcgcggag catcaagccg aacacaaagg 1209601 tcatttatat ggagacgcca tcaaatccga cacttgggat tacggatatt aaagcagttg 1209661 ttcagcttgc aaaagaaaac ggctgcctga cctttctgga caatacattc atgacgccgg 1209721 cactgcagcg tccgcttgat ctcggcgtgg atattgtact tcacagcgcg acaaaattct 1209781 taagcggaca cagcgatgtg ctctcaggtt tggctgctgt caaagatgaa gagcttggga 1209841 agcagctgta taagctacaa aacgcgttcg gcgccgtcct tggcgtgcaa gattgctggc 1209901 ttgtcctgcg cggattaaaa acattgcagg tccgtttaga gaaagcgagt caaacagctc 1209961 agcggcttgc ggaatttttc cagaagcacc cggcggtcaa gcgcgtgtat tatccgggac 1210021 tggctgatca tcccggcgct gaaacccata aaagccagtc aacgggagcg ggcgccgtgc 1210081 tatcttttga gcttgaaagc aaagaggccg ttaagaagtt agtcgagaat gtgtcactcc 1210141 cagtcttcgc tgtcagcctt ggcgccgtgg aatcgatttt gtcctatccg gcaacgatgt 1210201 ctcatgcggc aatgcctaag gaagagcgtg aaaaacgcgg tatcactgat ggcctgctcc 1210261 gtctgagtgt cggcgtcgaa catgcagacg atttagaaca cgatttcgaa caagcgctga 1210321 aagaaattgc tccagtttcg gttcgttaaa aaagaagccg gggatagtcc ggcttctttt 1210381 attattgttc gtcatcagga ttcagaatcg cgaggacttg atgatcctcc caaacgccat 1210441 taatttttac attttttcgg gcgatgcctt ctttatgaaa tcccgctttt tctaaaacac 1210501 gcatggaccc gagattacgg ggcatcacac cggcttcaat ccgatgcagt ttcaattcgt 1210561 ggaacgcata atcaacaacc aatctgactg cctctgtcat aatgcccttt ccattatggg 1210621 ctttgtctaa aaaatacccg atgaacgcag tttgcagcgc gccacggatg atttgaaaga 1210681 gcgaaaccgt cccgattaat ctatcgtctg acgctgtaaa gatgccaaaa tgatattctt 1210741 catctttctc aagtctttcc tgatactcgg ttattcgttt tctttgcccc tcaaccgtat 1210801 agtaatcgtc tgcgcgtatc atagaaaact gttcgaaaaa atctcgattt tcgctttgca 1210861 gccccagatt ttcttcggca tccgttactt ctaaaggtct aacataaatg gtttttcctt 1210921 ttaacatata gtgatctctc cgttctcatg tcagcattcc tcttacatta ttctcaggga 1210981 aatgcaaata tcctttttat aagaaggaag aaaaccaatt tcccataaaa gtgccaacat 1211041 agttgccgat taagtagccg agcgtaccga caagcatgat cggggcgaca agctcccgcc 1211101 atcccttggc aattgccatc gcagccgcag tcgtcggtcc cccgacagta gcgttgacgg 1211161 cgagcagaat ttcttcaagc cgcacacgga acaattttcc ggcagctaag gaaaccgcta 1211221 aattgctaat cgcaatgata aacacgaata atagaataag aggcgcattc gtgacgatta 1211281 agcggagatc tgcaggaatg ccgatcacca caaaaaacaa ataaatcaaa aaggttccaa 1211341 gctcctgaga tccattgagc ctttcaaaaa aacgcgggaa aagaaaaatg ataagaacag 1211401 ttaaagacgt aagaaccagg tactgatcgc caagcgtacc ggtcagcagg ggatgagaaa 1211461 aaatgctttt aaaataaccg gaaaccttca tactaaccgc aacaagcgcg aaagcggcac 1211521 cggcattaaa agcgatatcc tttaaggaaa tatccttccg tttccaatag ctttcagcac 1211581 tgtttccgct gtttccatcg gcttttacct tctcttcaaa cggcatggca taatgccgct 1211641 gaaaccattt gagtgcagga atgctgatta aaataaaaaa caaaagcgcc atcataaaat 1211701 tatcagccac aacggtagcc gacacatatt caccaggcgt ctcaaatttt gccgccatcg 1211761 ccgcaaagtt gaccccgccg ccgatataag aggcgctgat catcccaccg attttatcta 1211821 agtaaggaat atgctgtttg agtagaaaaa aagccaggat actgccaagc actgttccaa 1211881 cggagctaat cagaaaaata aacagcaaac gcctgctttc cttaaaaatt tgcctaacat 1211941 tgatctgaaa caataaaagt ggtatcgcca gcggtaccac ataagaccac acagtgtcat 1212001 acacgggcga ctcaacagga agcactccta catttgtaaa caccatagca cctgcaaggg 1212061 cgataatagc gcccgacaca gcagacgccc acttaaagcg ctgctccagc ccgatgctca 1212121 ctgccgccca caccgcaata aacccccata atacccatac atcatcagaa gaaatcaaag 1212181 aatgcaaaac cccatcacct ctattgttag aaaattaaga catattataa tagccgggga 1212241 acggaacagc aagtccaaaa aaagtttttc taaaaaagca gttgacgaat agaaggtaag 1212301 gttatataat agaacttgtc agaaagataa caacataccc agcaacacat acatatcatg 1212361 attccgtagc tcagctggga gagcgctacc ttgacagggt agaggtcgct ggttcgagcc 1212421 cagtcggaat catagcttaa acccttgcgc agcaagggtt ttttactttg cgttaataaa 1212481 gccggttcgt caaattcgtg agttgttggc gaactgttgg cgaaattcat tgaccgcagt 1212541 ccaaaaacta cctccaaact tacttgatta gttcaatagt aacaaacgga agatcggatt 1212601 tctgttaaat cttcattgag aatagccagt ccaagaccgt cacttcagcc atgcatcttt 1212661 taaatgaaat tttgtactga aaacatcaat tgtattttta aattctgctc tagaatcagc 1212721 ccctttataa taatcttgat aaattgcttg gggtgatact gattcgtgat ttgtgctatg 1212781 gtttgcaagg cttgtagcaa aagcaggagc aacagtaacg agtaaagcaa gggataatgc 1212841 aaaaccagtt aaagcttttt caatttcatt ttaagcactt ctttttttaa aatacaactt 1212901 tattattaaa tggaatacaa aaacatccaa ggtgtttttt tgttagtaag ttgagttagg 1212961 gggattggat ggcacttaga atattgtttc tgctgatggg atgttgattc tggatatatt 1213021 tccaacacga ttacaggccg gacatgaaag cgaaccttgc tttgatcggg gcaatcattt 1213081 catttacggc tgcggtttac tttaaagata ttgatgtatt gagagaagag ggaaaacaaa 1213141 tgaacggaat ttctgagcgt tggaacacgt ttaaattaca aaaatcccct gaaccactct 1213201 agatcagggg attgctttcc caacagctta ttaagtagcg gaaggcatga tcaacgattt 1213261 agtatcaatt tattaattgc gaatactaga aacataccgt tttccgcctt ccttagaagt 1213321 aacatattct cgaggaacat taagtctatt ggtagaatga taacttacat aaagtttcat 1213381 atttgctcgg ctcgttacga tagccgtatg atccatccaa ccatcagcat agcgaagacc 1213441 tattttatta tggtaatcat agtgatatac atctccaagc tttacatttg aatatgtatc 1213501 agaaacagtc ttcattttta ttccgccagc ttttaaaatg tatgatctaa aggctcctgc 1213561 attaacccaa gcatctgtat agggtttcca ttctttaaag tacggcattc ttccagctct 1213621 taatgcttgg gaaacaaagt tagtacaatc tttgtcttta taatatttat agtttttatt 1213681 tggttttaag gcatattttt ctgcatattt cattgcagcg taaccactat atcctttaac 1213741 agatgttgca gtcacagtta gttgattaga gttagcagca ttgaagttca tacttactgg 1213801 tttatcttca cttttcactt cttctttatc atcatttttc acttcttgct tatatttttt 1213861 taaaaattca tctaatttaa catccgaaga atattcttca tcattttcat attgtagagt 1213921 tgaagaagaa ttatttaatt gtgttacatt tagttgctta gaagaattac tcaatggtat 1213981 tacatttagt tgattagaag aatttttaac ttgagagaaa cttagattag aagtatttgt 1214041 tgattgagaa ctttgtttat tagaagttgt tttgggaatt tcaagtttaa tattatcgcc 1214101 cagagatgtt gttacttttt caacaccaaa aacaaagttt cgagtaatat aagcttcaac 1214161 aattagctta ttgttttttt cagaagtctt aacatcgtct atatcgtatg taaactcgtg 1214221 gaatttttgt ttgtccactt tacttaacgc agaatacagt aagactcctt cgtcggaatc 1214281 agtcaattta gactctttag gatgcgctaa aggagtgttg tgttcaaaat catatttttg 1214341 ttgttctaac atatccttaa ctttttcgta accaatctcg ttggtaattg aaacattttc 1214401 tttagtctct ttattagtag tggctgcaaa aacttcattt gttgacacta atggtgacaa 1214461 tgatagacat aaaactagtg aagcaagtaa ttcttttttc atacgaaacc tccaataaaa 1214521 tctaaatata agtaatattt atcatttaca ccaattgaaa tatggcataa aatacatgta 1214581 ataatataac ataaaaataa atacataaaa aggtatcgga ggaaaaaatg aaaaagaaaa 1214641 ctaaaattat actttctctc ttggcagcac ttattgttat attgatagta cttccagttc 1214701 tatctcctgt tgtctttaca gcttcttcgg aaaaaggagc aatcagacac gaaatttata 1214761 aaagaggata tccctaccaa agctactttg cagttctcca gaaaagagaa ggagacaatg 1214821 aatctgggaa tctttattat gtaaattggc tagattggaa agatgaaaca gggcaaactc 1214881 ctcacttatg ctattcgaaa aaatcatcag atggtgaata cgaagtaagt tgtggcacag 1214941 ggccgtaaaa ataaatttta aaattgaata agtccaagac ggaaagcctg cggacactga 1215001 tcgttttaca gagaaatttg tgcttcgatc ggtgtccgtt ttttttcgca actaaccaga 1215061 tgtctatcgc gattactagc tatgaaagga gtaattagac atgaaacagt ccaaaaagaa 1215121 accatcacag aagcaacatg agcgcttaga tcgtttctgg caacaaatga tgaacactaa 1215181 catgcaaaca ctcagacgtg gcaaaggcgg cgcttataaa cgcagaaagt aaaaagggag 1215241 tttgaggatg atgaaaaacg gattcgctta taaaaacgga aagcttgtga atatcttttg 1215301 cggcaaagaa gagctctata acgagttgaa agccttcttg gtcaaaacct tcagtatcaa 1215361 cgtgaaagag gtatcgaggc cctcaatata tcgcagaaca aaaagcaaac aactggaatg 1215421 acacttactc tatttaacta tcaggaggga aagcactatg acagatcaaa tgattgcatg 1215481 ggagattgag gaatggattc gtgattataa attcatgctg cgggagatca aaaggctcaa 1215541 ccgtgtatta aacaaagtgg attttattag cacaaagctc actgcaacat acggggagga 1215601 agcgggcatg ccaaggggat cagcaggcgt cagtcaggca gaattgcggc agatggaccg 1215661 aagagaaagg cggcttcaca aatatgaatc tattgtgcat tacctggaca atgcaatgga 1215721 acacattgaa gaagaaaagc accgaatcgt ttacgattgc atgatggaag gcatgagcta 1215781 cactgctatt gcaaaccacc ttgattgctc ccgggatacc atcagaaaga tcaaaacagc 1215841 cataatcggc aacatcgtca ataaagtcaa agaagccaac tttctgcaat atttgaattc 1215901 gtttaaatcg gcggtgtaaa atggggggca ggatcggcgc ggcggattat tcctgcgtca 1215961 ccaccaattt catacaatga gtaaaacctc ccagtggtaa gcgaggatca actcaactgg 1216021 gaggtcttac atagtgaatc ggtgataaaa cagcagcagt attgcgtaca tgttaatatc 1216081 cccgacaaaa tatgtttttt tcaacagatt cgttcgacaa attttgcaaa ttgttaatcg 1216141 ataacttttc attcccgata ttaaaaatgg gagtgaattg taaaatgaaa aaacagaaaa 1216201 ataataaaaa gaagaatatt gaaaagcgaa atattgaaaa gcgaaatatt gaagagaaga 1216261 ataatgagga cttagaagaa ctggaaaatg cgatttatac ttatcacaaa aaggagctac 1216321 ttgctttctt tcttgaaaaa actcgaattg gtcatgataa ggaagaatac aaaaggttcc 1216381 aatctcttct ttataagttg gatattgaat gtttagaatt tgctatatcg agattttctc 1216441 atatagatat tatccatgat cattcaaaat atgttccagc ctttatccct ttatttgcag 1216501 catatctcac catgttcttt aatttttatg aaaaacattg gggagcttta tcttttgctg 1216561 ctggtacaat tgctgctatt gtttggataa ttgcagtaga aagaaaacat agaaatcaag 1216621 caatttctat tatgaaaata tttgaacaag tcaaagagag aaaagtgaaa gacagatcta 1216681 aagactgaaa ggagaaaata tgaataagga taaattaagg tatgcaatct taaaagaaat 1216741 ttttgaaggt aatacccctt tgtcagaaaa cgatattgga gttactgaag atcaatttga 1216801 tgatgctgtg aactttttaa aacgcgaagg gtatatcatt ggggtccatt attcagatga 1216861 tagacctcat ttatacaaat taggacctga actgacagag aaaggtgaaa actacttgaa 1216921 agagaatgga acatggtcta aggcctataa gaccattaaa gagattaaag attggattaa 1216981 ataataagag catcctgcgg ggtgcttttt ttgttccctg taaactgctt ccggtaagtc 1217041 tcaggataga caattggcgg ttaacggctt gagcacggtg gtggtttaga gggaatatct 1217101 tttccaaaac aacacgaatc agaagggggc ggcggtgaat gtagatggcc gaaaagcaca 1217161 ttcaggcgta taaggattac gtcaaaggca tgaaatacaa ggaccttgcc gagaaatacg 1217221 gggtgtcagt gaacaccatt aaatcgtgga agcagcggca tggttgggaa aggaaaaagg 1217281 gtgcacccat tgaaaaaagt gtgcacacaa aaaaaggcgg gcaaccgggc aacaaaaatg 1217341 cattagggaa caatggcggc gcaccacaga agaatcaaaa tgctgtgact cacggctttt 1217401 tctctaaatt cttgccagaa gagacgcttg aaatcatgga agagattcag gagcgttcgc 1217461 cagctgatat gatatgggat cagatacaga ttcaatatgc ggccattctt cgggcgcaaa 1217521 agatcatgtt cgtttctgat aaggaagaaa tgatcaaaga gctgaaaaag aaaaggtccc 1217581 tcatatctga ggtcagcgaa attgaagatg ggcttgtcat tagttttagt acgtggtttc 1217641 gctacagact ttacagtgaa acaaacacct aacacatttc acattgcttc agattgcctt 1217701 caaacttgat aatataactt ctaaaccttc ctataaaatg aaggtttttt atttgatttc 1217761 aatttttaaa tcctttacat acagcgattg attaactcga gcaatcaatg tcgcagttat 1217821 atttattttt caagaaaatg ttataatgaa aagccataaa atgatgggag ggggaatttc 1217881 gatgcattac ataacggcat gtttaaaaat catcagtgat aaagacctta atgagataat 1217941 gaaggaattc aaaaaacttg aggaagaaac gaacaaagaa gagggttgta ttacattcca 1218001 tgcttatccg cttgagccat cagaacgtaa aataatgctt tgggagattt gggaaaacga 1218061 agaagctgtg aaaatccatt tcacaaaaaa acacacaata gacgttcaaa aacaagaatt 1218121 aacggaagta gaatggttaa tgaaaagcaa tgtgaatgat tgaaaggctc tttaaaaaga 1218181 gacattcaat gacttagtat cagccacttg tgactaagta gtaaattgtt gtccaactct 1218241 tattttttct atttaatatt ttttgagacg aaaatgtttt tttaagctga ttttaaaatg 1218301 tattcaaagt cagctctgtt tgatttaatg gattatatta tttggatagc ttgttaccat 1218361 cataatggag atactcctta taaattggag gttaaaataa tgagtcattc tcaagaaaaa 1218421 attgcactaa ttacaggagc aagcagtcaa ggggatattg gtacggctat ttgtcgtaag 1218481 ttagcctcac agggtataca tatcttcttt actcactgga attctgatac ggcctggata 1218541 gaagaatttc aacaagaaat tttacgtatg ggtgtccgct gtgaggcaat gaaaattgat 1218601 ttatcagatg cacatgctgc attcacaata catgaaaaaa tttcagataa attaggatat 1218661 ccttccatcc ttattaataa tgcagctcat tccgcaagtg ataattatgt atcgttagat 1218721 gctaaatcac ttgatgagca ttatgcggtt aatatgagat cgaattttct tctttgtgtt 1218781 gaattcgccc gtcggtttaa aaaatctaat ttaatatcag gaagaatcat caatatgaca 1218841 tcagggcagg atttaggtcc tttgcctggg gagttagcgt atgcagcaac taaaggagct 1218901 atttctgcat ttactaggtc gttatcacaa gaacttgcac cattgggcat cactgttaac 1218961 gccgtaaacc caggtccaac agattctaca tggatgacag atgaaataag aaattttctt 1219021 tcacctaaat ttccaatggg gcgtattggc acaccagatg atgcagcacg aatgattgcc 1219081 tttcttgcaa gtgatgaggc tgaatggata actggacaaa ttattcattc agaaggtgga 1219141 tttattcggg gctaagctaa tgaaacacgg tatacaccaa tgtatgatgt attcccaaaa 1219201 ctaaatctaa acttgaagcg aaaataaggt cccttctctt tttagagggg gaccttattt 1219261 tattcatgca tgttttgcat ccagaaaatc tggcggataa agattaataa accgttacat 1219321 atacttttcc gaatactgca gtacctttaa acaaagtaat cgtggctttc ccttttgatt 1219381 tagccgtcac taaaccattt tgatcgactt cagcaacttt ttggttatca gtccaataac 1219441 gagtagctga attattttta acagaatagg tttctccaac ttttagaggt aaattatagt 1219501 cttgaatctt gataacatgt gtaggtgaaa tagaaatgtt ctttacttca gtaggtgtgg 1219561 agtttatttc atgagctgaa gctaccccgc tgaccgacag agctaacgca gaaatcgata 1219621 aagcagaaac aaccgttttt ttgaaattca ttttgaaaca ctcctttaaa gttttttgtc 1219681 ttgcactata acaattcaat aaaagtaatt attttccttg taaataaatg ttaataatat 1219741 gtgaacgatc aattgatttg agctaagaat attgtgtgcc ctgcacagag tttgtattta 1219801 tgatggaaaa ttgctgagag agaatggcca tccttaaaat gttaatagca cacatttgat 1219861 gggtattagt ttgttgagcg tgtggaaatt ttgttacctg cactttatcc ccgaagatac 1219921 caaatcactt ttcttcatca tgttcttact ttcgtactca tacattagaa aatcttcgtt 1219981 ctaaataggt gaagaattgg agtattttta tgaatttctg ctgaatatac attacatagc 1220041 aaactcaaag agtataaaaa tcgctttttt ccggaagctt cggtaaaaaa cgaaactttt 1220101 gtctctatga ttttgtttta taatgtaaac ggtttcttat atagtatact tatactatca 1220161 atttgctcaa gtagatactg acaggaagga tagaaaaaca gatggaatac ataaatacaa 1220221 gacaaaaaga gattttgtat ctgttgttat ctgaacctga tgactattta gttgtgcaag 1220281 atttcgcaga tagggtacag tgttctgaaa aaacaatccg gaatgatttg aaagtgatcg 1220341 aggattatct caatgagcat tctcatgcac agcttattcg aaaaccaggg ttgggcgttt 1220401 atttacatat agaagaacag gaaaggacct ggctaagcca acaattacat actgaacatt 1220461 tttcttctag gcagcggagc gataaggaaa gaatgctgca cattgcttat gacttattaa 1220521 tgaatccgaa gcctgtttcc gcaaaagaca ttgccgctcg gcattttgtc aatcgatctt 1220581 ccattaaaaa ggatttatac gcagtagaag agtggctgaa gcgttttgat ctcacactgg 1220641 tttctaggca gcggcttgga ttaaaggttg aagggaacga aagaaataaa agaaaggcat 1220701 tggcaagaat atctgatttg attcacaata cagcgtttac cagccaattt attaaaagta 1220761 agtttttaca ttatgaagta gactttgtga cgaaagaaat caaatcacta caaaaaaagc 1220821 attccctcta tttcacagac gaaacgtttg aaagtttgtt gctgcataca ttgttaatgg 1220881 tccgccgcat caaaatgaag cagccgattt cattgtcccc aaaagaaatg gcggcagtaa 1220941 aaaagaagaa agaatatcaa tggacatttg cttgtttaca gcggcttgaa ccggtttttg 1221001 caattcgctt ccctgaagaa gaagccgtgt acttaacatt acatatattg ggcggtaagg 1221061 ttcgttatcc attgcagaca gaagagaacc ttgaaaatgc tgtgcttcct aaggttgtag 1221121 ggcatttaat caatcgtgtt tcagagctga aaatgatgga ttttcacaag gatcaggatt 1221181 tgatcaatgg tttgaacatt catctcaata ctgtgctaca acggctgagc tacgatcttt 1221241 ctgtagcaaa tcctatgctc aatgacatca aaaagatgta cccttatttg ttccacctca 1221301 tcattgatgt tttggaagac atcaatcaaa cttttgatct tcatattcct gaggaagagg 1221361 cagcatattt gacattgcat tttcaggcag cgatcgaacg gatgcagggc agcagcgaga 1221421 cacataaaaa ggcggttatc gtctgccaca tggggattgg gatgtcacaa ttgctgcgga 1221481 caaaaattga acggaaatat caccaaatcg ctgtaatggc ttgtattgca aaggccgatt 1221541 taaaggatta tatcaaaaag catgaggata ttgatcttgt catatccacc attgcgctgg 1221601 agaatataac ggttccccat attgttgtgt ctccgctttt agagcctggc gaagagaaga 1221661 aattaagtgc gtttatacgt cagctgggcg aatcacaccg ccaaaaacaa aaaacgtttc 1221721 agatgctgaa caatacgact ccttttttgg tttttttgca gcaggaggcg gagcatcgct 1221781 acaagttaat cgaacagctg gcgacagctt tgtttgagaa aggctatgtt gataaggact 1221841 atgcggttca tgcggtgatg agggaaaaaa tgtcggctac aaatattggg tcaggcattg 1221901 ccattcctca tgcaaacgct aaatttatta aacaatcagc aatcgcgatt gccacattaa 1221961 aggagccgct tgaatgggga aatgaaaaag tttcgctcgt ttttatgctg gctgtcaaac 1222021 acgaggatca aactatgaca aagcagctgt ttagcgagct ttcatatctt agcgagcagc 1222081 cggccttcgt ccagaagctg acgaaagaaa ccaatgtcat gacattttta tctcatttgg 1222141 attattaaaa gcagggatta ttccttgctt tttttgttca tggcagggct tgagaaataa 1222201 atttgcgagt gaagacgcct attctccagc aatgatctaa ataaaataag agtttaatag 1222261 ttggagaaga aatgttacac tcttttctgt atatggtaaa gaatgaaaaa acacgattcg 1222321 gttggtagtc cggatgcatg attgagaatg tcagtaacct tcccctcctc gggatgtcca 1222381 tcattcttta atatctttta tgaggaggga atcgttatga aattaacgat ttactacgat 1222441 ggtcagtttt gggtaggcgt tgttgaagtt gtggacaatg gaaagctaag agcctttcgt 1222501 catctttttg gcaaagagcc gagggattct gaagtattag agtttgttca taaccaactt 1222561 ttgaatatga tggcccaagc tgagcaggaa ggagtgcgtt tacaaggcag gcgtcaaaaa 1222621 aagatcaatc caaaaagatt gcagcgccag gtttcaaaag agttgaaaaa cgccggagta 1222681 acttctaaag ctcaagaggc gataaagcta gagcttgaag caagaaagca aaagaaaaaa 1222741 caaataatga aagaacaacg agaacatgta aaagagcaaa ggtatatgct caaaaagcaa 1222801 aaagcgaaaa agaagcacag aggtaaataa tccaaacaaa agcaggcgca gtgcctgctt 1222861 ttgtaattaa ggactctact ttgtaacata tatccaatgt ttatactccg ctgatttatg 1222921 attcaatata aaccctaact tctccaaggt tttttgtgag cctagattat catgttcgca 1222981 tcttgcggtg atccgggata ctgtttctcg gcttaatgcc cagtttatta gtttttgggc 1223041 ggcttccaca caataacctt tgcggcgatg acttttattt gttgcaaaac cgatttcaat 1223101 catgccattt tcgtctgggt cacctaaaaa tccagttccc ccaacaattt cataattgtc 1223161 cttctttaca ataatccatg aatcaaatcc ttttgttcca ttgtttttga ctaaaatctc 1223221 gcggaaataa ggtatcgctt caaaaaaatc agaatttggc cattcaccat ttgtttcata 1223281 gcctaattct ttgatagcct gatgatcttg tttagacgcg gcgtcaagaa ggggaatatc 1223341 aatcgtttgt aatcgtaatc gattcgtttc aaggagaacc atatatttaa tcctcttttc 1223401 tttttactgg gaataatgat aacatataac aattttctct ggtaccttgg cagtagagaa 1223461 agatgaaaaa attgaggggg attgaaagag tgacaggtga gagtttgccc agaccaaaaa 1223521 cgggtaggaa aatgctgatg ttaatgtgtc cctacccgtt tttctgttcc tgaatgcagg 1223581 gtttctgata acatgttgtg ctaccttttc gcaatcaaat aaagcgatat ggctctttgg 1223641 gtttgcacag gattatgaat gataatgacc cattggtttc ttcgtcttgg aaagcttgct 1223701 accgcataca atggagcagt atcgcgcgga gtgaacccac catttatcac gttgatatct 1223761 cttccttcaa gatgacaaac taagtattca cctggattga tgacctgttg gttcgtccat 1223821 gcgtaagaat aaaagccgtc tccaagatct tcggtggaag atggggggac aaagccatct 1223881 acagtcaatg tgatttctct tcttcgctgt ctttctgaaa agtctggact tctttgaggg 1223941 ttatgagtat gtgaaaagta aggaattaac gcagggccat aaaagtaatg atacaaagca 1224001 accactcctt tattttccat tcatacaaat tgtatgtggg agttatttgt tcattcctgt 1224061 tttgttccat gtagactaat aatgggctat aggcgtccaa ggaaatcaat ttgtccttcc 1224121 gttgattcaa tgctagtaac cttgaaaatg caggttagga tgatagaatt tacatattac 1224181 tgcaagaagt tagacataca tcattttgat agtgggtgaa aacaatggcg aaaaaaatgg 1224241 caaaaacaaa tgcggttcgt ctgatagaac agcagaacat ctcttatgag gtattagggt 1224301 ataaaacaga cggccagccg gtagatggca tctctgttgc ggaaaaaatc ggttattctt 1224361 tgaaatatgt atataaaacg ttggttgcag cagcaggaac aaatcattat tatgtctttg 1224421 ttgtacccgt tgcagaagag ttagatgtaa aaaaggcagc aaaggtgaca ggggaaaaga 1224481 aaatagaaat gattgcaatg aaggagctgt tagcggtaac tggctatctt cgcggcggct 1224541 gctcgccaat tggcatgaaa aaattgttcc cgacctatat tgatgcatct gcagaaacgc 1224601 ttgattttat tattgtcagt gcagggaaaa tcggtatgca gctaaagttg gcgccacaag 1224661 atttagccag atcatgtgat gccgcatttg cagaaattgt atagatgcag atatagggga 1224721 acgaaaaagc ttagtcatat cgattaagct ttttccgcat ccctttcaaa tatgatttca 1224781 aaataagcag ctgccccata cccatctata ctgggagcga aaatctgaac gaatctccag 1224841 cctcttttcg cataatcatg gatgatttgc tggtagtctt ctttaggcct tcttctcatc 1224901 gtactcagct caactcttac gaattcatat tctttcatcg tttgatccct cctattaagg 1224961 tatacgtaaa atggagcgag aagttccgaa aacctaggtt aaggtcggaa agtatatttc 1225021 actcactaaa caaatccatt tatgcctgat gcctgcatgc atctgggaag agttaagggg 1225081 ctataaaaac gaattttacc gggtcagcag tccaaatgaa tctcttgctt attgcatttg 1225141 actgagtata taagtaaaaa aagagcggcc agaacatata agaaggagat gatcattaac 1225201 gcactcataa cagggtagtg tttagcggag tagatgaaaa aatcaagctg tgaaatttgt 1225261 ttggggctgc tgacggcatc aattccatta agcagttttg agagtttagc agtatagttc 1225321 caatcaaatc gatctgaaac aagctcgctt ccttgatacc aattaacagc agctaaaaac 1225381 agaaatacca taatagaaaa tccaagctga acaactaaaa atattccctt cacttttgta 1225441 tgacctccaa atctatgaat atgggaaaat caaacaatat attaccaccg tatgggttat 1225501 tcttgcaatt tcacttccat acaactcaaa cgcaagtcta tttttttgtt tgtttttggc 1225561 ttataatacc tgatgatgga aaaagagtgc gggtttatag attagagaaa caaatgtatt 1225621 tcttagcatt ttttatttgt ggagagagta tagaagcatt cgattagatc tgctttttca 1225681 cagaaacggt tttcatctgt ttgcctgagc tttacaattg gctggcaaaa aaacaatgat 1225741 ttctttcaat caaaacatgc aacgatgcga cacattttat atcttgatga cttatttcat 1225801 tgcctttaag tcatcctatc gagaaagcga tggtatttta tgaacaaaga aaccctaaaa 1225861 aacatactca tgattttttc aatatgcgca acactccgag aaaccgatgg tatgcgcata 1225921 gctgatagct ggattttgag tgagattata cgatttttga tttgcatggt tgtgtttttt 1225981 gccatgacat ttctattaga tgctgttttt ccaaacaaaa aagagtcaca ttaatgtgtg 1226041 gctctttttg catcatctga tcagaaacat cataaatgaa tcgatcatca tgatgaagaa 1226101 cagcaagcaa aaataaataa gcgagtagac aaacatatcc tttgcccact tcacgtcatc 1226161 gtctgttttg aatcctttga tgcttttttt gatccatatg cctccgagaa ccaaggcggc 1226221 taagaaataa aatgggctta tatggccggt gccgagagag aaaggaaata atagcgtgac 1226281 cggcaccagg acggcaatat attgcatcat ttttattttt gttacatgat tgcctttgac 1226341 tactggcaag agcggaacgc cagcagcgcg atattcctct ttgcgtctta tcccaatcgc 1226401 ccaaaaatgc ggcggctgcc acagaaacat aatcgtgtac aacagcactg ctgtcatact 1226461 gaagtcaccg gttacggcac aataccccat caatggcggc gcagctcctg ggaagctccc 1226521 gacaaatgtg ctccacacag acgttcgttt cacccatacc gtatagatga tcgcataaaa 1226581 aataaaggcg gccagtccga gaaaggccgt taatggattg agggaataaa gcatggcaag 1226641 acctgcgatt cctaaaacag agccatatgt taagatcatg gctggcggca ttttccctgt 1226701 gaccgaggcc ctgctgcgag ttcgtgccat ttttgcgtcc atatgccgat caaaatagtt 1226761 gttatagaca gtgccggaag ccatcacaaa cgcggttccc aacattgctg ttaccattgt 1226821 catcaaaaaa gccaagccgg ttaacgtttt ttctgcgctt gcaaacgcga tccaaaaccc 1226881 gccgaaggct gctatcgagt ttgatatgat aatgcccggc tttgcaagtt tgataaaatc 1226941 gtaaatggtt acccggttcg aagcttttat gtattttgtt tcagatatgg ctgcagaatc 1227001 tcttgtattc tccaaaaata gacgcctccc ccaaaactgc atgcttttgt tatcgtaaca 1227061 agagggggac agaatcacaa ttatttccca tatttgtcat gatattgtca tttttaaaac 1227121 aaaaaaatgg ggagctggac tgcccccatt ttgatatgtg gcgactagta accgtaacct 1227181 cccccatatc ctccgccata acctccgccg taaccgtacc aagggtagta aggcggtcgc 1227241 gggcgcgggt agtaataagg cgggcgcgga taaaacgggt agaacggata atacggtctt 1227301 ggataataat aaggcggata aaatggcggt ctcggacgcg gataataata aggctgtctt 1227361 tcatcataag gggtaatttg ttcaaatgac tgttcattca aagggtaatc caagaggaaa 1227421 acctccctag ctttttttat tccttttacc atattcctga tgcttaagtt gggtgtatgt 1227481 acattcatga aattcggttt tttttatgat gaaattcctt aaaaaggatt gacatgaact 1227541 tctaaatctc atagtattac aaatgtgaaa taaatgttac tacaatgtta caaaaacatt 1227601 tctaaataga tacagttcca actgatgaag agtaaatcga aatggctacg aaagaaggag 1227661 tttttgttgt tggcaaaaag aatcaaatgg tttcatgtat taatagcagt tgtatgtgtg 1227721 gtgggcctta tcggcttttt ccataatcat tcattgaaaa aagaaacggt catgaataaa 1227781 gtaagaactg attctcaata tgggaatgtt gagatcgcaa cgcttgtgaa tgacgggaaa 1227841 acttttaatt acgcggtaaa ctatcctgtt ttcaaaaatg aaaaaatgga ttcggcatta 1227901 aaaagattcg cagaaaaaga ggttcgtcaa tttcaaaagg aaacaaagga cgttgaccaa 1227961 gagcatacga caaaacgcaa cgaattaaat gttgattata aaattgtcca ttatgccaaa 1228021 cagacagtgg cgattgtatt taatgaatat aaatacatcg gcggggcaca cgggcaaacc 1228081 gtgaaaaaaa cgtttaacta tgattttagt aaacaagcgt ttctttccat tgatgatatt 1228141 ttcaaagagg acgctgacta cttacataag ctttcgttaa tcgcttatca cgagctgaaa 1228201 aagaataagg acattgccgc ggacgatgca ctgttaaagg aagggacggc tccgaaaaaa 1228261 gaaaatttca gccgctttgc catcaaggag gattatatcg aactttactt tgacacatat 1228321 caggttgcag caggctatct tggagagcaa tcgattgcca ttaagaaaag tcttttgaaa 1228381 gacattctga aagaacaata tattgataaa gcaaaaaata aaaataaaat caaagaacaa 1228441 aagccgaagc atgaagtgat ttctttaccc aaagaggaaa cagttgatcc aaatcaaaaa 1228501 gtcattgcgc ttactttcga cgacggcccg aatcctgcga caacaaatca gattctagac 1228561 tccttgaaga aatataaggg tcatgccacg ttttttgttt tggggagcag agttcaatat 1228621 tatccggaaa cgctaataag aatgctgaaa gaaggaaatg aggttgggaa ccattcatgg 1228681 agccatccgc ttctcacaag gctttcagtg aaagaagcgt taaagcagat caatgatacg 1228741 caagacatca ttgaaaaaat aagcggatat cgtccgacgc ttgtaagacc cccatacggc 1228801 ggcattaatg atgaactgcg gagtcaaatg aaaatggatg ttgcgttatg ggatgttgac 1228861 ccggaagatt ggaaagaccg taacaaaaaa acaattgttg accgtgtcat gaatcaggcg 1228921 ggagatggaa gaaccatttt gattcacgat atttaccgca cctctgctga tgcggccgat 1228981 gaaattataa aaaagctcac cgatcaaggc tatcaattgg tgacagtttc tcagcttgaa 1229041 gaggttaaaa aacaaagaga agcgaaataa attagaaaag gctgtccgta cggacagcct 1229101 tttttctatt taataagagc ctgtggtggc ccaaacattt aagtttggtc ctgaatactt 1229161 gccgaaagcg taagaagtcc ttggatctaa atcatatacc atcggtgtat agcaagactt 1229221 ttggccggcc accgcttttc cattgccgcc tgcagaatca caattatatc tttttccgtc 1229281 tgtgttccgg gtaatctccg catttgcttc atagccagac gtcaatgtat tattcatcgt 1229341 gatttttgcc caagccgttt tacatgtact gctgaattta agctcgacta ctccgatgac 1229401 ttgattgctg gcattcacta agtttgagga tttttttgta gagccgctgg acgcacaatc 1229461 attgtaataa gggctttttc catcgtaggc atgggtttcc gccttggcgg gtgcaccttt 1229521 gacggcaaaa acaaatacta ctgcgaataa caccaatgaa gccttcataa acagtctttt 1229581 caatttatga cctccttaat atggcaaaca ataaatcata tggaggaaca atcaaaacat 1229641 gcatgctttt ttgtgaacaa taaaggcggc cgggaggatg gagttcttgg ccgcctctgg 1229701 tatgaggtta tgcttttaca tcaatggttt gtccgagagt tggatgttga atcatcttta 1229761 aggtttgatc ggcattttgc tgggcggtgt ccagcctttt tttcgttaaa gcaatattta 1229821 cattctgggc aagggatgct tgatgcatcg caaccgataa agcaggaata tccatggttc 1229881 cacctcctat gccttaccta tcggcgggtt tgtatgattt tacagtgaaa aatggcttaa 1229941 tttctcttgt tgacccttac gctgcggcat atcgtatgtt tttgacaagg agggaatcag 1230001 gatgaatcta gtaatggaaa agacctttga gcaatacgaa aagctgtttt caatggaaga 1230061 acagaaaaga gaagatgtat ttcggtatac gatgatgagg ccgtttgaaa agatgtggac 1230121 cgccatccaa gttccgctga aagcgaagga gccaaacggc tatgatgtga tcatggctgc 1230181 gaaaatgctg ggctatttgg atgtccgtga tgctgaaagc ggccagaaag cactacaaat 1230241 actgaaagaa tcacatgttt cagagacagc tgaatctgca cttcggcaat gcatattttt 1230301 tgctgagcgc gaacagctgc gggtgaatgc aaaggagatc aaattcggcc tttatatcgc 1230361 tgatccaaat aagcttcagc tgcaaaaagg ctactgcggg tttggcggga taccgggctt 1230421 tattcatgta tggattaatc cgaacagtta taacctgcca aggattcctt ccattattgc 1230481 tcatgagttt catcataatg tgcggttttc gtatatagat tttcatcatg gctctgtaag 1230541 tgtcggggat tatcttgtga ttgaaggatt ggcggaatca ttcgccagag agctgtttgg 1230601 tacggaacga ttgggccctt gggtaactcg ttttgatcat gaagacttgc aatattccat 1230661 tgatgtgatt aatgaggtgc tggatgtgaa aggattttcg gaagtcagcc gttatatgtt 1230721 tggtgatcca attgctaacg accaaggctt taagcctgca ggtttatcgg cttttgcggg 1230781 ttatgcagtt ggctatcatg ccgttcagtc atttatgaat caacatcata tcacgataag 1230841 cgaggccaca cgtttggatg cgaagaccat tatttctcaa tgcggtctgt tttctacatg 1230901 aaaaaagcgt cacatacagc ggcgcttttt gattcccaaa accagcagtt ctatggcggc 1230961 acaggcggca attccgattg tatatgcttc gatatcgctc cataaaaaac cgtaccctag 1231021 tacaagcccg ccaagagaag tatctctaat ctggtcgatc cattcggcat gatagagctg 1231081 gctgaattca atgacaaaac agaaagaaag actgataatg cccgttatca ttgtcttcag 1231141 cttccgaaat agaaatccgc atcccgtgaa gatcatggcg gcccacaacg agtctcccag 1231201 ataagtattg agggtatcag gaagaacact ggagaatgct ctggatccaa gccccagccc 1231261 aatgatcagt atggtgaaaa ctgcatatat ccaacgattt cgcttcattg cgaattgata 1231321 ccccgtctct gcttcatctc cctgtattgt aaggaatata gcttttattt gtccactaaa 1231381 aaagcggctg aatagccgcg tagggtgttt attttgcttt taggtttaca tggtcggctg 1231441 tctgatccgt gcctattaca aaatggagtt catagcggcc tgtatcatat acataatcga 1231501 tttcatcggt aaacgggacg gttaacaccc gatttactgg tcctaattgc ttctgcagca 1231561 cttccggcgt aactccgcct aaattcagct gccgttccac accggttcca aagtagcgga 1231621 tttctgaaat tgtcatgtct ttatgatagg aaaatccgta gcccggctgt cccatattcc 1231681 agtgatataa atcaaatcga ttgtctcccc cgactggtct ttccggttcc ccaaacgcag 1231741 cgtggacatc cccttttgtg cttttgttaa tggtaaggcc ttgcgcctgc tgaggcattt 1231801 cccctttata ggcggtgtta tagaggtttt tgacaagctc agcggctgat tgattcgtgt 1231861 tttctgagag tgtgtttgtt tgagctgcgg cctttgccgg tgctgaaaag gacgcagccc 1231921 caaagccggt aaaacagctt gttactgctg ctgccgcggt tatagcagac attgtctttt 1231981 tcatgttaat ccctcctaat tgatctacca ttccgtttcc ccgtgttttt gcaacgaaac 1232041 atgtgagtgc gctttgtatg ttttattgag ttgttgtaag ggaactgaaa taggtaattc 1232101 ggtatataaa gcaagaaagg ggaatggaga tggctggcaa gaaaacaatc acaataaacg 1232161 gcgttgaaat ggaagcgtcc gaggaacaga cggtgctgca gcttttgaat aacagctcga 1232221 ttgaagtgcc gcaagtttgc tatcatccaa gcttagggcc gattgagaca tgtgatacgt 1232281 gcatcgtcag catcaatggt gagctgaaga ggtcgtgctc cgctgaatta aaggatgggg 1232341 atgtcattga tacgctctca cctgacgtga aaaaagcgca ggtcatcggg atggacaaga 1232401 ttttatataa tcatgagctt tattgtacag tttgcgatta caacaatggg ggatgcgaaa 1232461 tacataatac ggtgaaggaa atgaaaatca atcaccaaag cattccgttt gatcacaagc 1232521 cataccataa ggatgaatcc catccgtttt atcggtatga tccagatcaa tgtatattgt 1232581 gcggacgctg tgttgaggca tgccaagacg ttcaggtaac tgaaacgctg accattgact 1232641 gggagcggaa acgcccgcgc gtcatttggg ataacgacgt gccgatcaat gagtcgtcat 1232701 gtgtgtcatg cggccattgt tcaacggtct gtccgtgcaa cgcgatgatg gaaaaaggaa 1232761 tggaagggga agccggatat ttaacaggca tcaataacga aacgctgcga ccgatgatcg 1232821 agatcacgaa aggcgtagag acaggctacg gctcgattct cgcgatttct gatatggaat 1232881 cggccatgcg tgatgaacga atcaaaaaaa cgaaaaccgt ctgcacgtat tgcggcgtcg 1232941 gctgcagctt tgatgtctgg acaaagggca gagacattct gaaagtagag ccgcaggagg 1233001 aagcgcctgc caacggcatt tctacttgtg tgaaaggcaa gttcggctgg gatttcgtta 1233061 acagcgaaga acgcctgaca aagccgctga tccgtgaagg cgatcatttc cgtgaagcag 1233121 agtgggagga ggcgttattg ctgatcgcca gcaagttcac tgaattaaaa gaggcgtttg 1233181 gcccggattc tctcgctttt attacatctt ctaaatgtac aaatgaagaa tcctatctta 1233241 tgcaaaagct ggccagaggg gtcattggca caaataatgt ggacaactgc tctcgctatt 1233301 gccaatctcc tgcgactgcc ggcctgttcc ggacagtcgg ctatggcggt gattcaggat 1233361 caattacaga tatcgcgcaa gcggaccttg ttttgattat cggttcgaac acgtctgagt 1233421 cgcatccagt cttatccact cggattaaac gggctcataa gctgagaggg cagaaagtga 1233481 tcgtcgcgga tatcagaaag cacgaaatgg cagagcgctc agatttattt gtccagccgc 1233541 gtgccggatc ggatatcgtc tggctgaatg cgatcgccaa atatttaata gaaaacggca 1233601 aggccgatga acgatttttg agagaaagag tgaacggacg ggatgaatat gtaaaaagcc 1233661 tcgcgccgta cacacttgaa tatgctgagg agaaaaccgg gattgatcaa gaaaccctta 1233721 tccaaatggc agagatgatc gggcaagctg acagtgtgtg cgcattgtgg gcgatgggcg 1233781 tgacacagca tattggagga agcgacacga gcacggcgat ctctaatctg ctgcttgtga 1233841 caggaaacta cggaaaaccg ggagcaggtt cttacccatt gcgcggccat aacaacgtgc 1233901 agggagcaag tgactttggg agtatgcctg acagactacc gggctatgaa aaagtgacgg 1233961 acgaacaagt ccgccaaaaa tacgagcgtg tgtggggtgt gccgctgccg aaggagccgg 1234021 gtatgaccaa ccacgaaatg attgaaaaaa tccattccgg acagttgaaa gcgatgtatg 1234081 taaaaggtga agaaatgggc cttgtcgact ccaatatcaa tcatgtacac gctgcatatg 1234141 aaaagcttga tttctttgtg gtgcaggaca ttttcctttc acgtacagcg gagtttgctg 1234201 atgtggttct tcctgcgagc ccgagccttg aaaaagaagg aacgtttaca aacacagaac 1234261 gccggattca gcgtttgtat caggtatttg aaccgctggg tgaatcaaag ccggattggc 1234321 agattattat ggaggttgcc aataagcttg gcgccggctg gctctatgag catcctgcag 1234381 acattatgga ggaagcagcc aagctgtcgc cgatttatgc cggtgtcacc tatgaacgtc 1234441 ttgagggcta taattccctg caatggcctg taaacgctga tggaaaggat tcgcctttac 1234501 tctttacaga gcgcttccct ttcccagacg gcaaggccat tctctaccct gtccagtgga 1234561 cagagcctaa ggaattcggt gaggaatatg atatccatgt caacaatggg cggctcttgg 1234621 agcacttcca cgaagggaac ctgacttaca aatcaaaagg gatttcggag aaaacaccgg 1234681 aagtgttctt agaaatttct cctgagcttg cggcagaacg agggattcag gacggaaccc 1234741 tcgtcagact cacatcgcct ttcggaaatg tcaaagtgaa gtgcctgatt actgatcgag 1234801 tcaaagggaa ggaagtatat ctgccaatga acgattcagg ggaagcggcg atcaacctgt 1234861 taacaggcag ccatgccgat aaggataccg atacgcctgc ttacaaagaa acatcggcca 1234921 agatggaaat tttgaagcac gacggaatca gcccgctgcc taagatcaac caccgcaacg 1234981 gcaatccgca gccgcaaatc ggtgtgcagg ttcataagaa atgggcgcgg aaggattata 1235041 ttttccctgg tgacgctgtg aaaaggggga tgggccataa tggctaaagc gattaaacga 1235101 atccaaaaaa tcgaggtaac agaagaggat cagcgaaagc gtgatttgcg ggaaattgaa 1235161 gatgctctaa ttgaccacaa agaagcgatt ctcgaaacat tgcatatgct gggccatatg 1235221 aacgagcgcg gggtcctgcc gttgctccgc ggcctttttg gtcaagggga taaagttctt 1235281 gatatcctgg tgaaaaaggc agatacagag gaaacagcca atacgctgaa aaatctgctt 1235341 cttctgtttg gaacactcgg catgctggac gtgaagcagc tggagcctct cattttgaaa 1235401 gtgaatgcgg gtgtggcaag cgctgtagag cagaaaaaca gtgaagaaaa gacaggttat 1235461 tttgatatta tccgctcgct aaaagacccg gaaatcaaca aatcaattac actgctcttt 1235521 tcctttttaa aaggaatggg acaagataca aaggagctgg aacgcacgac gcagcctccg 1235581 gaacaccaaa aacatcatca ggaaccccga gagaaaagag gaatgaataa gcgagattga 1235641 cctcccaccc gagcggcttc agccagctcg ggttttttga tgaaaaggtc taatggacta 1235701 gtaaaaaata ttcaaatact aggaagaagt aagattgtga tgaatgagat agaaataatc 1235761 gttactttct tacctgttaa gaaaagggaa aatctgatta taatagaaat cgattacttt 1235821 agatggggga acaatcatga aaaaagtctt attactatta tttgtcttga cgatcgggtt 1235881 agcgctttct gcgtgcagcc aatcgagcga tgcgtcagag aaggaaaaac cgaaagagaa 1235941 aaaatcgcaa gaagagcttg aaaaggaact tgataaggaa ttgaaaaaag gcggtgagcc 1236001 gaagaccaaa aaagatgatc aaatacataa aataggagaa acatttaaag caggacatac 1236061 gaattttaca gtgaataaag ttgatagagt gcaaaaaggt gaatatatga atgttggcgg 1236121 agctgtaaat gaggagacaa aaacaataaa agatgatgag gaacggctta ttatagaagt 1236181 tacgatggaa aatatagggg aagattcaat aagctacaat tttatcgggt ttgatttaag 1236241 agataagaat gatcaatcag tgcggcctgt tttttctata gaagagaagg gcagaatcct 1236301 tatgggagga acactagtat cggggaaaaa ggttacaggt gtactcagtt atgtcatccc 1236361 taaaggagaa cagaaacatt acacactggt atataatccg tttttagctg atacaaatag 1236421 cagtaataca gaagagagag taaaggacga tattgattac ttggtgaagt tagattagat 1236481 gctaatttac agttgcacgt ttttcatctg tggaaaacgt gcatttttta tagcgaaact 1236541 tgacttgaaa ggatgagtga taaaagtgca aaccaaatgg ctggaacggg cacagcggat 1236601 tcgggcgatc gcccaagcgg ggcttgcttt ttccaaggat gtgtacgaca gggagaggta 1236661 cgaagagcta atgaagctta gcgcggaaat gatggcggat tactcggaga aggacattga 1236721 agttatcact gatttatggc aaggcgagaa gggctatcca acaccgaaag cggatgttcg 1236781 cggcgctgta ttcagagaga atcagatttt gcttgtccgg gagaagcatg atgagctgtg 1236841 gtcgctgccg ggcggatttt gcgagattgg tttatcgccg gctgaaaacg ttgtcaagga 1236901 aatcaaagaa gagtcggggt acgatacaga gccgtctcga ttgctggccg tgctagacag 1236961 ccataaacac tctcatcccc ctcagcctta tcactattat aaaatcttca tcgcatgcag 1237021 catgacggac gggcaggggg aaacagggat cgagacgaat catgccgctt tttttccgga 1237081 agacagactc ccgccgcttt ctcctaaacg aaacacaccc tcacagctta gcatgctgtt 1237141 tgactttttg cgccatccgg acaagaaaac gatatttgac taaaaaagaa agagcctgtg 1237201 ggctctttct tttttataat gtaatgtgtt tttcgttggc gagtttcaga agggtcaaaa 1237261 tagaatcggc ttgtttatgg ccgagttttt gctttaattt gttttcttca actaatcggc 1237321 tgccataaat tttgacggag gctttgtcga cgacagtatg ccagttttcc tgtttttttc 1237381 cctcaacaag cggtttttca tgtctctcag aaaaagagaa cacaaagagt acgaatgcaa 1237441 gtgaaagtag gattccgaca acttgttttt tgtaatcagt ctgtgctgcc acgttgttct 1237501 ctccttcacc ttttaccttc tatttaatca tagaaccaaa ttattttaca taatgggaaa 1237561 gtcatttttg gagttagtgc atttggttga aaacagagac gttttttgag cggagcggtg 1237621 caattgaatc catattggat ttgcgtgctt atgcctaagg tcacgttgtg agccaaaaca 1237681 gcagtgcaga atagaaaaaa attgaaagat tatggtaaga tgaacgaaat tcgaggggga 1237741 atatatgatg cctgcatcga acatcgtgat cgcctgcctg ctgttatcaa tttaattatt 1237801 tgtggtagtc cctctctttt tcgaaagcgg gaggtgaagt ggaacattaa ttgctgaatt 1237861 ctttcaaggg gagtgaccgt acatgaatgt gttaaaccgc cggcaagcct tgcagcgagc 1237921 gctgctcaat gggaaaaaca aacaggatgc gtatcatccg tttccatggt atgaatcgat 1237981 gagaaaggat gcgcctgttt cctttgatga agaaaaccaa gtgtggagcg tttttcttta 1238041 tgatgatgtc aaaaaagttg ttggggataa agagttgttt tccagttgca tgccgcagca 1238101 gacaagctct attggaaatt ccatcattaa catggacccg ccgaagcata caaaaatccg 1238161 ttcagtcgtg aacaaagcct ttactccgcg cgtgatgaag caatgggaac cgagaattca 1238221 agaaatcaca gatgaactga ttcaaaaatt tcaggggcgc agtgagtttg accttgttca 1238281 cgatttttca tacccgcttc cggttattgt gatatctgag ctgctgggag tgccttcagc 1238341 gcatatggaa cagtttaaag catggtctga tcttctggtc agtacaccga aggataaaag 1238401 tgaagaagct gaaaaagcct ttttggaaga acgagataag tgtgaggaag aactggccgc 1238461 gttttttgcc ggcatcatag aagaaaagcg aaacaaaccg gaacaggata ttatttctat 1238521 tttagtggaa gcggaagaaa caggcgagaa gctgtccggt gaagagctga ttccgttttg 1238581 cacgctgctg ctggtggccg gaaatgaaac cactacaaac ctgatttcaa atgcgatgta 1238641 cagcatatta gaaacgccag gcgtttacga ggaactgcgc agccatcctg aactgatgcc 1238701 tcaggcagtg gaggaagcct tgcgtttcag agcgccggcc ccggttttga ggcgcattgc 1238761 caagcgggat acggagatcg gggggcacct gattaaagaa ggtgatatgg ttttggcgtt 1238821 tgtggcatcg gcaaatcgtg atgaagcaaa gtttgacaga ccgcacatgt ttgatatccg 1238881 ccgccatccc aatccgcata ttgcgtttgg ccacggcatc catttttgcc ttggggcccc 1238941 gcttgcccgt cttgaagcaa atatcgcgtt aacgtctttg atttctgctt ttcctcatat 1239001 ggagtgcgtc agtatcactc cgattgaaaa cagtgtgata tacggattaa agagcttccg 1239061 tgtgaaaatg taatagataa ggagactgga gattcatgaa aaagtaccat atttcgatga 1239121 tcaatatccc ggcgtacgga catgtcaatc ctacgcttgc tttagtagag aagctttgtg 1239181 agaaagggca ccgtgtcacg tacgcgacga ctgaggagtt tgcgcccgct gttcagcaag 1239241 ccggtggaga agcattgatc tatcatacat ccttgaatat tgatcctaag caaatcaggg 1239301 agatgatgga aaagaatgac gcgcccctca gccttttgaa agaatcactc agcattctgc 1239361 cgcagcttga ggagttatat aaggatgatc agcctgatct gatcatctat gactttgttg 1239421 cgctggctgg taaattgttt gctgaaaagc ttaatgttcc ggtcattaag ctctgttcgt 1239481 catatgccca aaatgaatcc tttcagttag gaaatgaaga catgctgaaa aaaataagag 1239541 aagcagaggc tgaatttaaa gcctacttgg agcaagagaa gttgccggct gtttcatttg 1239601 aacagttagc tgtgccggaa gcattaaata ttgtctttat gccgaagtct tttcagattc 1239661 agcatgagac gttcgatgac cgtttctgtt ttgtcggccc ctctctcgga gaacggaagg 1239721 aaaaagaaag cctgttgatt gacaaggatg atcgcccgct tatgctgatt tctttgggta 1239781 cggcgtttaa cgcatggccg gaattttaca agatgtgcat caaggcattt cgggattctt 1239841 catggcaagt gatcatgtcg gttgggaaaa cgattgatcc agaaagcttg gaggatattc 1239901 ctgctaactt taccattcgc caaagtgtgc cgcagcttga ggtgttagag aaagctgatt 1239961 tgttcatctc tcatggcggg atgaacagta cgatggaagc gatgaacgca ggtgtgccgc 1240021 ttgtcgtcat tccgcaaatg tatgagcagg agctcactgc aaatcgggtt gatgaattag 1240081 gccttggcgt ttatttgccg aaagaggaag tgactgtttc cagcctgcag gaagcggttc 1240141 aggctgtatc cagtgatcaa gagctgctca gccgcgtcaa gaatatgcaa aaggatgtaa 1240201 aagaagctgg cggagcggag cgtgcggcag ctgagattga agcgtttatg aaaaaatccg 1240261 ctgtcccgca gtaaaaacat aaaaaccgaa atcaatttga tttcggtttt ctgtttaaat 1240321 attttttttc atcccgcatc tccggcattc tctaagaaat tttccgcctt ttacagagct 1240381 tttgaacagt gtgtaatcac agttgtcgca gcgcccgctg cgggcatccg gatattcatt 1240441 gaattcgtaa acaatcgatg tatcgtagcc ttttgtttca tattcttctt ttttggtttc 1240501 catgtcgatc ctccgttaca agacgtgtct gctgtttatc ttacagcaag cttccggcgt 1240561 attcaatgga ttttaggagg ttgggtttat cttgatttct cccttggttt gcgccaaaat 1240621 agctttatta agcttatata cataaaaagc ctatgcaaag aggagaggaa acgggtatgg 1240681 gaaaagggtt acttggaaaa cgcgtggcaa tcggtggctc acgaaaaacg gaagaaatta 1240741 gtacaatcat tgaaaaacag ggcggaatac ctgtcatccg gcctctccaa ggtacagttt 1240801 acttagcaga gaagcaggtg gagccggatt tgcggacgtt tgcggaagaa aaagctgact 1240861 gggtcatttt cacgacaggc atcgggttgg agactcttgt cgatatggca gagaaaattg 1240921 gactgaaaga tgagtttctg caggccattc gccaagcgaa agcggcatgc cggggataca 1240981 aaacgctgtc tgcgctgaaa aagcttggaa tcacaccgga agcttcggat gaagacggga 1241041 caacaagagg cttaatccgt tccttggagc ctcacgactt ttcaggaaaa acagtcatgg 1241101 tgcagcttca tggcgaaaaa gcgccggctc tcatggcatt tcttgaagaa aaaggcgcgt 1241161 ctgtcctgcc gattctgcct tatcagcaca tcccgccgga ggaggaaacg gtggagcggt 1241221 tatgccgaga gctgatgaac gatgaggtcg atgccgtttg ttttacaacg gccattcagg 1241281 ttcgttccct gtttgatttt gccaaggggc gaggttatat caatgaagtg aagaaggtat 1241341 tcgaagaacg cgccatcgca gctgctgtcg gaaaagtgac tgctgaagca ctgcgggaag 1241401 agggcattac gagactgctt gcgccagaga ttgagcggat gggtgcgatg attgttgagc 1241461 tggccaagta ttatgaagaa aaggaataac aagtacaaaa agccgctttt ccctcggaaa 1241521 gcggcttttg tctgtcattc attttgcttc agctgctgat gaacggtgaa taatgatggg 1241581 tatgtcagca cgcttaagat tacacaagtc agcgcggctg aggccatcgt tgtaaacacg 1241641 attaagagtt gaaagcgtac tgcctgaatc gggtccgcgc cggctagaat ctggccagtc 1241701 atcatgccgg gaagctggac aagacccagt gttttctggc tttcgagcgt cgggatcata 1241761 ctcattttca tcgctgaggt aagaatgcgc tgtatggatt gcttcggtgt gccgccaagt 1241821 gacaatatta attgaatttc ttctttgcga acgccgactt ctgagttaag ccggtttaga 1241881 aacaaacttg agagcaccat cgaatttccg atgaccatcc cgctgatcgg aatgacatat 1241941 cgtgccgtaa gcggaatgat atgaagagac agcagaattc cctgcgtcac aatttctacg 1242001 attgctaacg cggcaaacac cctccaaaac gaaccgatag tatttttctt tcgcttgatg 1242061 acattttgcg ccgccaccgc gagcattaac agcaccatca gcaggataaa aacagggtgg 1242121 tctccgcgaa aaatcagcga caaaacataa ccgatgataa gcagctgcac cgcggcccgg 1242181 atggtggcga tgatcatgtc tttttctaca ccggctttaa aggattttga taaaaacaag 1242241 gcgatcaaaa caaagatcat cgttaaagag agagaaaggt aatccattac cgagtgcctc 1242301 ccttcaaaaa ttctttcgct gcttcatgct gcggagcgga gaaaaatgtg tcggtttcag 1242361 cgatttcaag cagccggcca tctgccataa accaaatggt atcggctatt cgttttgcct 1242421 gctccatatt atgagtgacc cacatgactg tccatttttt ctcttgatgc tgacgtttga 1242481 tcagttcttc aatctcaaga gcagagaccg ggtccaaggc cgatgtgatt tcgtccaaca 1242541 atagaatgga ggaaggattt gagagcgttc tggccagtga cagtctttgc cgctgcccgc 1242601 ccgataagtc tctggcgctt ctgtctaaca actctggcgg cagccctgca agcgaagcca 1242661 gcttttcagg agagtacagc tgggattgat gcagcctttg tacaagactt aaattgtcac 1242721 gcactgtccc gtcgagcacg ggagccgatt gaaacgcgag ggctgccgtt cgcctcagct 1242781 cattgacatt ccattctctg acttcctttc cgtatatgtt gacttcgccg ctgtcaggcg 1242841 ttctcattaa attacacata gaaaggaggg tgcttttgcc tgagccggaa gggcctaaaa 1242901 cggctacgat tgcaccctgt tgaatgtctc cggtgacatc ctgcagcaca tcataggttt 1242961 gtccatcttg tttatagctt tttctgactg atctgaagga gatggctggt atgttttgtg 1243021 tttgatcgtt tgcttccatt acaataatca cctttcaata taagtaggct gacattatat 1243081 ttaactataa cgtgaaacag attccttttg gtagcacaaa taaaggagaa caggctttca 1243141 cccattctcc tgcagatgct acgcagtcag atttgactgt gctttctttt tcggttttct 1243201 cggctgtgaa gcgaaggtat gtaacatcat ccccgctatt ataatgaaca aaccggcaaa 1243261 tgataataga gatgggaaaa cgcctgacag cagaacaatt tcaccaagca gcgcgaaaat 1243321 cacttcaccg gattgagtgg cttcaacagc tgcgagtttt tgcggattgt ctcttaccat 1243381 atcagtggcc cagaaaaata aaaccgtcgc aatgatgcct gagctgacgg caacgataaa 1243441 ggattgaacg gtttgacttg ctgttggaag gccatctgac caccagccgt aagctgctaa 1243501 tataagccag aatggaaggc ttgccaatgt cattccaagc acgcgctgaa atgtatcaag 1243561 ccggcctccg tattcttcga gcattcttcg gtttcctaac ggataggcaa aagccgcaat 1243621 gacaaccggc agcacactga aaagcagcat cctcccagaa agcgattctg catgctgaag 1243681 ctgaatcaga gccgctccaa tcaggatgat cacagaagtg ccaagtgaaa ccaggggaat 1243741 cttttggcga atgagctgcg gaccgcccgg catatcttgt ttgacataaa acaaaggaga 1243801 taagagcacc ccggctacaa ttgtaatttg ccaggttcca gctatgagcc accccggacc 1243861 gtatgcagcc gcaaatgtaa tcggtgcgta aaaaagcacg aaaccgacga agctccattt 1243921 gatccaataa aacggctttt tcctcatttc tagtaagaga ggcgtgaatg tccctctcat 1243981 gatgacaatc aaacataaaa atggcaccat aaaaataaag cgcagcgaag agctccaaag 1244041 ccagctgcct cctgataact ccatcgctct gtttaatata aaggtaacgg cgaaaaagag 1244101 tgaagccaat attccgataa cgatagcttt catgatatcc ctcattctgg cattattttt 1244161 ttatactata ctattcggta tcatgcagat caatggaatc atgagaaaaa catcatgttt 1244221 ggcgaaccgc tatatgtgga agacaaaaaa gggaggtgaa attgatggaa agagagacac 1244281 agacatactt ctttccggat gacggcagga ttccgaatca ccctgatttt ccgctcgtgg 1244341 tgtatcaaaa cgcgcttaag gacaccggac tggcagagcg gatcgtcacc cggcatggct 1244401 ggtcaaacag ctggtcaggg agtgtttttc cataccatca ttatcacagc aatacgcatg 1244461 aagtcctgat tgcccttagg agagaggctg tgattcagtt tgggggagaa aaaggggctg 1244521 ccatcccttt caaatcaggc gacgcagtcg tgattccagc cggagtcgga cataaaaagc 1244581 tcagctcaag ccccgatttt actgtccttg gcgcctatcc cggtggcgtt cagtacgata 1244641 tgaagacggg gaagccgaat gagcgggagg aagcggtcaa acagattaag caggcggcgt 1244701 tgccggcgaa tgatccgatc acaggaaaaa gagagcctct attggaaata tgggtaaagt 1244761 gaaggggaga aattgctgga ttgtcaataa ctagtgccgc agaaacgata tgacatgagc 1244821 tccatataaa ttaatttcat aatcgaagca attcacgttc aaattttgtt caaaaagtgt 1244881 tatcatatag aaggtaatcg aattggagtt ttttgtgttt gctattttca gagagagtaa 1244941 aggattttga cttattcaat tgtttatttt tagataaaaa taatactgaa tatggcaaga 1245001 tgaaaaactg ggtagtaaac atttattttt gtaaatgatt gtgcatgaat tcacaatcct 1245061 tattcttatg ccttaaaagc gtgagacagg gagaggcact accctttcca aaaaaatcag 1245121 caaactgctt atagtaaagg agaattggat atgccagaaa caatcgatca aacaaatgcg 1245181 tctgtcagcc aaagccagca agatcttatt gatcagctat taaagccaga agttcaagaa 1245241 tcattgactg ttttagttga ccagcttccg aagctgactg agttagtgaa tattttaacg 1245301 aagtcttatg atttcgctca gtctgtagcg actgacgaag tgttaaagag cgacacagtc 1245361 ggtgcgatca ctgaaattct cgagcctgta aaagaaacag cgaaagaagt agctgcgact 1245421 gcgatcgaag caaaagaccg cgcggaagca agcaacgaaa caattggact tttcggcctt 1245481 cttcgcatgc tgaaagatcc tcaagctcaa aagctgttcc gttttgctaa cagctacctt 1245541 gaagtcatga acgaacgcga aaaccaaaaa taatctcaga ttcaaattga tataaaggac 1245601 ggaggatata cgatgtcaaa acatattgtc attctaggcg ctggttatgg cggagttctt 1245661 tctgctctaa cagttcgcaa acattacaca aaagaacaag cacgcgtgac agtggtaaac 1245721 aaatacccaa ctcaccaaat cattacggaa ttacaccgcc ttgctgcagg caacgtgtct 1245781 gaaaaagcgg ttgcaatgcc attagaaaaa cttttcaaag gcaaagacat tgatcttaaa 1245841 attgcggaag taagctcttt ctctgttgat aaaaaagaag ttgcgcttgc tgacggttct 1245901 acattaactt acgatgcgct tgttgtaggt cttggttctg taacggctta cttcggcatc 1245961 ccaggtcttg aagaaaacag catggtattg aaatctgctg ccgatgcgaa caaagtcttc 1246021 caacatgttg aagatcgtgt gcgcgagtac tctaaaacga aaaacgaagc agatgcaaca 1246081 atccttatcg gcggaggcgg cttaacaggt gttgagcttg ttggtgagct tgctgacatc 1246141 atgccgaacc ttgcgaaaaa atacggcgta gaccataaag aaatcaaatt gaaacttgtt 1246201 gaagcaggtc cgaagatcct tcctgttctt ccggatgatc ttatcgagcg tgcgactgca 1246261 agccttgaaa aacgcggcgt tgagttctta acaggtcttc ctgttacaaa tgtagaagga 1246321 aacgtaatcg atctgaaaga cggatctaaa gttgttgcca acacatttgt ttggactggc 1246381 ggcgtacaag gtaacccatt agtcggtgaa tcaggcctag aagtgaaccg cggacgcgcg 1246441 actgtaaatg acttcctgca atctacatct catgaagatg tattcgttgc tggagacagc 1246501 gcagtttact tcggtccaga cggccgtcca tacccgccaa ctgcacaaat cgcatggcaa 1246561 atgggtgagc tgatcggtta caacctattc gcttacctag aaggcaaaac gcttgaaaca 1246621 ttcaagccag taaactctgg tacacttgca agccttggac gcaaagacgc ggttgccatc 1246681 attggtgcta attctacacc gcttaaaggt cttcctgctt ccttgatgaa agaagcaagt 1246741 aatgtacgat atttgacaca tattaaagga cttttcagcc tggcttacta atccttttaa 1246801 tgaatctggc attgccaaaa gcattccttt ccgagtgctt tctggcaatg tcttttttta 1246861 tgtttatgac agcgttaaca tttcattttc aaaaaagaga ttgatcccaa aggaatataa 1246921 aggtaaaata aaaacaaatc aaaatgttaa cgttaacatt ttgaaataga atgaaagacg 1246981 gtgaggacat ggaacccttc atgggcaaaa actttttatt gaaaaatgaa accgctgtca 1247041 gcctctatca caattatgcg aaagacatgc caattattga ttaccactgc cacttaagtc 1247101 cgaaagaaat ctatgaaaat aagacatttc aaaacatcac ggaagcctgg ctgtatggtg 1247161 accattataa atggcgcatc atgagagcca atggaattga ggagacatac attaccggag 1247221 atgcgcctga tgaggagaaa tttatggctt gggcgaaaac cgtgccgatg gcgattggca 1247281 acccgctcta caactggact cacttagaat tgcagcgttt ttttggcatt tacgagattt 1247341 taaacgagaa gtccgggtcg gctatatgga aacagacaaa taaactgctc aaaggggaag 1247401 gcttcggggc aagggattta atcgtgaaat caaatgtaaa ggtcgtgtgc accacagatg 1247461 accctgttga ttctcttgaa taccatttat tgttaaaaga agacaaagac tttcctgtca 1247521 gtgtgctgcc tggatttcgg ccggataaag gacttgagat caatcgtgaa ggctttcctg 1247581 agtgggtgca ggcgcttgaa gatgccgctg ccatatcgat tacaacctat gatgagtttt 1247641 taaaggcgtt ggaaaaacga gtgcgattct tccactcagc cggcggcaga gtttctgatc 1247701 acgcgataga tacaatggta tttgccgaaa caacaaaaga agaagctgga cggatttttt 1247761 ctgacagatt acaaggaaca gaggtttctt gtgaagatga gaagaaattt aagacatata 1247821 cgcttcagtt tctttgcggt ttgtatgcgg agctcgattg ggcgatgcag tttcatatca 1247881 acgctttaag aaacacgaat acaaaaatga tgaaaaggct cggacctgat acagggtatg 1247941 attcaatgaa cgatgaagaa attgctaagc ctttatacaa gctgctgaac tcagttgaga 1248001 tgaagaacca gctgccgaaa acgattttat attcactgaa tccaaatgat aactatgtca 1248061 tcgccagcat gatcaacagt tttcaggacg gtattacccc gggaaaaata caattcggca 1248121 cagcctggtg gtttaacgat actaaagacg gaatgctcga ccaaatgaaa gcgttatcaa 1248181 atgttggcct tttcagccgt tttatcggca tgctcaccga ttccagaagc tttctttcgt 1248241 atacgcgcca cgaatatttc aggcggatcg tctgcaattt gattggagaa tgggtggaaa 1248301 acggcgaagt gccgcgcgat atggagcttc tgggaagcat cgttcagggg atttgctatg 1248361 acaatgcgaa acactacttt caatttcaag aagagaaagc aaacgtgtaa caaagtgtcc 1248421 gctcagtatc gctgagcgga tcactatccg aaaattctta agacacagag gtggaacatg 1248481 cgaactgaac tggcaaataa ggttgtgtcg gtcgaaacgg aaaaaaggct ttcattgaaa 1248541 gagaaaatgt cctatggctt tggtgatttt ggcaacggtt ttatgtttga tctcggccag 1248601 atttatttat tgaagtattt cactgatgta gcgggaatcc ccgctgcgat ggccggcggc 1248661 atttttttag tcagtaagct gtttgcagcg ataacagatc caattgtcgg ctcatcaatc 1248721 gattatcgca aaaacatcgg caaacggggg aaattcaggc cttatctatt aatcggcagc 1248781 atcgtgcttg cggtgcttac tgttcttatt tttctgtctc ccaatgtatc aacgaccgga 1248841 aaactgatat atgcatatgc atcctatatg atttggggca tcggctattc gtttgtgaat 1248901 attccgtacg gctcattagg ggcagcgatg actcaaaatt ctgaggaccg gacctccatt 1248961 tcgacgttcc gccaaatcgg atcacttggc gccttgttta tcacaagtgt ggccgtgatg 1249021 ccgctgctcg tcaagtttga taatccgaag gtcggctacc cggtggtcat gggcttgttc 1249081 gccgcgctcg gtgtgttttg gttttatatt tgctaccgca actgcaaaga gcgcattatc 1249141 atatcggaag cacccaaaga aaaattaaca ctctcatctg tcgtcaaaac atttattaca 1249201 aataaaccgc tgttaaccct tgtcctgatg acgatttttt caatttccgc atacaacatt 1249261 aaatccgcca tgctcgtcta tttcgcacaa tataacttgg gcaatgttga attaatggct 1249321 tatatgaact tcatcattat tggttcttcc tttttgggcg tcgtattcct tccaaagctc 1249381 gtcaagatgt ttggaaagaa acgaacggca atgatcggct ttggcatcag tgtggccgcg 1249441 gatctgatca actttatgct tccatctaac gtttatgtgt ttacaattct cgccagtatc 1249501 gcctttatcg gaatcagtat cccaaatggc atcacgtggg ctcttgtctc cgatattatc 1249561 gactatggcg aatggaaatc cggtgaacgg aaggaagcaa cgacatattc acttttcaat 1249621 ttctcaagaa agcttgctca atctttgtct ggctttctct cggggatcgg tttggggatt 1249681 atcggctatg tgccgaatgc agtccagaca gcacaggcgc tgattggcat caaagcgctg 1249741 cttcttctgt atccggccat tgctttggca ttagcgatgt tcattatcgg ctttctttat 1249801 aaactcacag accagcagca tgctcagatc gttcaggatc ttcatcaaaa gagctgacaa 1249861 tataatataa agaatattta aaataatttg taaataaaat gtgtttgtag gggtttcgct 1249921 tggagagtgc ccaaaaaact gaaaaggaag gaggcacttg cttgaaaacg ataacaattg 1249981 cagctgaaga agcaaaggaa ctcgtttggc aaaagctgga cggtgccggt ttgaatgaac 1250041 gagatgctga aaaagtggca gatgttctcg tgcacgctga tttgcgcaat gtacattcgc 1250101 atggcgtgct gcacacagaa cactatgtga acaggctttt agcgggaggg atcaatcctg 1250161 gggcacagcc tgtttttaaa gagacggggc ctgtgaccgg ggtgcttgac ggagacgatg 1250221 gtttcggtca tgtgaattgc gacatggcga tggaccatgc aattgacatg gcgaagaaaa 1250281 aaggagtcgg catggtcacg gccgtaaaca gcagccattg cggagcgcta agctattttg 1250341 tgcaaaaagc ggctgacgaa aagctgatcg gaatggcaat gacgcataca gacagtatcg 1250401 ttgtcccatt tggggggagg actcctattt tagggacaaa tccgattgct tacggagttc 1250461 cggctaagca taaaaaaccg tttatcctag atatggcgac atccaaagtg gcttttggga 1250521 agattctgca ggcccgtgaa gagggcaaag aaattcctga aggatgggga gtcgatgaaa 1250581 acggagaagc agtaactgat cctgacaagg tcgtctcact ttcaacattc gggggcccga 1250641 aaggctatgg actatcgatt gtagtggatg tgttttccgg attgctggcg ggcgcggctt 1250701 ttggccctca tattgccaaa atgtacaacg gccttgatca aaaaagaaag ctggggcatt 1250761 acgtttgcgc gatcaatcca tcctttttta ctgactggga tacgttttta gagcagatgg 1250821 atgccatgat tgatgaactg cagcaatcac cgccggctgt tggattcgaa agagtgtatg 1250881 tgcccggcga gatcgagcag ctgcatgaag aaagaaataa gaaaaacgga atttctatcg 1250941 cccggagcgt gtatgaattc ttaaaaagca ggtgagtaaa atgaaagcgg ttcaagtgcg 1251001 aaaagcgtat gatctggtga cagcggaggt gaagaagcca gttctttcaa aggatgatga 1251061 agtgctcgtg aaagtcaagc gagtcggcat ttgcggttca gacatgcaca tttatcatgg 1251121 aacgaatccg ctcgctaccc tcccgagagt catcggacac gaggtaacgg gacaagtgga 1251181 ggcagttggt gcgaatgtac agagcctaaa acccggtgat catgtggtga ttgagccgat 1251241 ttcttattgc ggatcgtgct atgcctgccg caaagggcgg ccgaatgttt gcgccaagct 1251301 ttctgtattt ggcgtacatg aggacggagg catgcgggaa tatattgtgc ttccggaaag 1251361 acagcttcac gcggtctcaa aggacttgcc ttgggaggaa gcagtcatgg ccgagcctta 1251421 tacgataggc gcccaggcag tgtggagagg ccaggtggaa aaaggtgata ccgtcctgat 1251481 ccagggagcg gggcccatcg ggatctgtgt gttaaaaatg gcaaaactgg cgggcgctgc 1251541 tgtcatgatg actgacttga acaacgagcg gctggcattt gcgaaagaaa acggcgccga 1251601 tgctgttgta aatgtccaag cagaacatgt tgccgagcgg gtccttgaat ggactgggaa 1251661 tgaaggagca aacgtggtca ttgatgctgt ttgcctgccg gagacttttg cactttcaat 1251721 tgaggctgtg tcaccggcgg gacatgtggt tgtgcttgga tttgatgaaa gagcggctca 1251781 gatttctcag ctgccaatta caaaaaaaga agtcacgata accggatccc gattgcagac 1251841 caatcagttt ccaaaagtgg tagagctttt gaatggaggc cggttaatgc ataacgggct 1251901 ggtgacccat acattttcag ttgatgacgt tcatcatgca tttcagttta ttaaggagca 1251961 tccagatcag gtgcggaaag ccgtcatcac gtttgattaa atgactgaat ccggaggtgc 1252021 gagcatgaat atgacattcc gatggtatgg acgaggcaac gatacagtca cacttgaata 1252081 cgtgaagcaa attcccggtg tcaaaggcat cgtttgggct ctccatcaaa agcccgtcgg 1252141 cgacgtgtgg gaaaaagaag aaatcagagc cgaaactgaa tatattcaat cctatggttt 1252201 tcatgctgaa gttgtagaaa gcgtgaatgt tcacgaagcg attaaacttg ggaacgaaga 1252261 acgcggccgg tatattgaaa actacaagca aacgatccgc aaccttgccg gatttggcgt 1252321 gaaagtgatc tgctataatt ttatgccggt ttttgattgg acacgcacgg acatgttccg 1252381 gccgctagaa gatggatcga ccgctctgtt ttttgaaaag gccaaggtgg aaagccttga 1252441 tcctcaagag ctgattcgga cggtggagga agcatccgac atgacactgc cggggtggga 1252501 gcccgaaaaa ttggctcgga tcaaagagct ttttgctgcc tacagaacgg tcgatgaaga 1252561 aaagctatgg gacaatttat cattcttttt gcaggaaatt cttcctgttg ctgaggccta 1252621 tggtgttcaa atggccattc atccggatga cccgccgtgg ccgattttcg gactgccgcg 1252681 cattatcaca ggagaggcaa gctataagaa actgcgggcg atatcagatt caccgtctaa 1252741 ttgtatcacc ctttgtacag gttcaatggg agccaatccc gctaacgaca tggtggagat 1252801 cgctaaaacg tatgccggca tcgctccatt ttcacatatt cgcaatgtga aaatttatga 1252861 gaatggcgat tttattgaaa catctcattt aacaaaggat ggttcgatca acattcaagg 1252921 cgtgatggaa gaactgcata agcaggatta cgaaggatat gtcagaccgg atcatgggcg 1252981 ccatctttgg ggcgagcaat gccgcccggg atatggctta tacgatcggg cacttggcat 1253041 catgtatttg aacgggctgt gggacgctta tgaagcaatg gcaaaaaaag aggtgggcat 1253101 atgatcccgc tgcatgagaa cctggctggt aaaacggctg tcatcactgg cggcagcggc 1253161 gtgctttgct ctgcgatggc ccgggagcta gcccgtcatg gcatgaaggt ggcgattttg 1253221 aatcggacgg ctgaaaaagg ccaagcggtc gtgaaggaga taacggcggc tggcggcaca 1253281 gcgtgcgctg ttgctgcgga tgtgctggac aggatgtcac tggagcgggc aaaggaagac 1253341 atccttggcc aatttggcgc tgttgatctg ttaattaacg gggctggcgg caatcatcct 1253401 gacgcgataa ccgatgtgga gacatatgaa gaagcgggag aaggccaatc cttttttgat 1253461 atggatgaga ggggctttct aactgtattc tccaccaact tcaccggtgc gtttctggcc 1253521 tcgcaagtgt ttggtaaaga actgctgaag gcggattcac ccgcgatcat caacctttct 1253581 tccatgagtg cttattcacc tatgacgaag gttccggcat acagtgctgc gaaagcatcc 1253641 atcaataatt ttacgatgtg gatggctgtt cattttgccg aaaccgggct gcgggtcaat 1253701 gcgattgccc caggcttctt tctgacaaaa caaaatcatg atctgctgat caaccaagac 1253761 ggaacgttca ccagccgatc tcacaaaatt attgcgggaa caccgatgaa gcgcttcgga 1253821 aaaccggagg atttgctcgg tacgctcctt tggctggcgg atgaatccta ttccggtttt 1253881 gtcactggga tcaccgttcc tgtcgatgga ggatttatgg cttattcagg tgtgtaacga 1253941 aagcggtgca acagaaactg aaccaacata ggggtgaggt tgagatgttt tcaaaagata 1254001 agcttcccgt tatccttttt ttgttcctgg caggggtgat taattacctg gatcgctcgg 1254061 cgctttccat tgcagctcct tttattcagg atgatctcac attgtctgcc acacaaatgg 1254121 gcttgatttt cagcagtttt tcgataggtt atgccatttt taattttctt gggggcgtgg 1254181 catccgaccg ctatggggca aagctgacct tgtttgtcgc gatggttgtt tggtcgctgt 1254241 ttagcggagc agtcgccctc gcttttggct ttgtcagcct gctgattata cgcattctct 1254301 tcggaatggg agaaggcccg ctttcggcga ccatcaacaa gatggtgaac aactggttcc 1254361 cgccgaccca gcgggcgtcc gttatcggtg taaccaacag cggcacgccc ctcgggggag 1254421 ccatttccgg cccgatagtc ggcatgatcg cagtggcgtt cagctggaag gtatccttcg 1254481 ttctcattat gattattgga ttgatatggg cagtgctctg gttcaagttt gtcaaagaaa 1254541 agccgcaaga gacgatcaag gaagcaccgg caataaaagc agaaacgtct cccggagaaa 1254601 aaattccgct caccttttac ctgaagcaaa aaacagtcct gttcacggcg ttcgcttttt 1254661 tcgcttacaa ctacatcctc ttcttctttt tgacatggtt tccgagctat cttgtcgacg 1254721 agcggggatt aagtgttgaa tcgatgagtg tcatcacggt cataccgtgg attttaggat 1254781 ttatcgggct ggctgcgggg ggatttgttt ctgactatgt gtacaaaaaa acggcccgaa 1254841 aaggtgtgct gttctcgcgc aaggttgtgc ttgtcacgtg tttgttttca tcagctgtcc 1254901 tgattggttt tgccgggctt gtggcaacga ctgcgggggc tgtcactctt gtcgctctgt 1254961 cagtgttctt tctttatttg accggtgcta tctattgggc tgtcattcaa gatgtggttg 1255021 atcaaaacaa tgtcggttct gttggcggct tcatgcattt cctcgccaac acggcaggaa 1255081 ttatcggccc ggctttaacc ggatttattg ttgaccaaac aggcacgttt tctggagcat 1255141 ttttgcttgc cggtgggctg gctgtcttcg cttcacttgc tgtgattcgt tttgtccgtc 1255201 caatcattgg taagccagcg ggaacagaag ctgagaatcc tgtgtcttat taatctggaa 1255261 atatagtggg agaggcggta tgtttgatga tacaatatac agtaaataat cgcagccggt 1255321 atgataagga agggaattag atggtaacca taaaagatat cgcaaaactc gcaaacgtat 1255381 cccacactac tgtttccaga gcactcaaca acagccctta catcaaagaa catacgaaga 1255441 aaaaaatatt agagctagca gagcagctca actatacacc aaatgtaaat gcgaaaagtc 1255501 tggcgatgca aaagtcgcat acgatcgggc tattctttac aagcattaca aacggaacct 1255561 cacacagctt ctttgcagac actatcaaag gcgtcaatca agccataagt gaggattaca 1255621 atctgtatgt gcgcggcatt gatgatctga aaaactatga ctccgttaca ccgatgagat 1255681 atgacggcat cattttaatg agccaaagtg acattgataa ttcttttatt taccatattc 1255741 gcgaaaaaaa cattccgctt gtcgtgctga atcgtgatat tgatgatcgt accatcacga 1255801 atattttgtc caatgacaag gaaggctctc aagaagctgt agaatacttc attcagtccg 1255861 gacatcaaga catcgccatc atcgagggga tcgaaggctt taaatcctcc cagcagcgaa 1255921 aggaagggta cttatccgca ctgattcaac atcatattcc gatcaagcat gaatacagtg 1255981 tcaaaggaca gtacgatatg gaaagcggct ttcaagcgat ggagcggctg ctggcactgc 1256041 cgaatcctcc aaccgctgtt ttttgttcga atgatgacat ggcaatcgga gcgatgaatg 1256101 cgatattcgc aaagggcctg cgcgttcctg atgatatttc ggtgatcggg tttgatgata 1256161 ttgggttttc acagtacatc acgccaaggc tttcaacagt aaagcgccca gtggagaaaa 1256221 taagcgtgct cggtgcgcaa aaactcttgt cgctgatcag cgagcccgaa acaaaagcag 1256281 aaaaaatctt ggaaaacaca gaatttatgg tgcgtgattc agtcagacga ttgacgacgt 1256341 gatgtcccgt ttttcagcgg gcattcttta tacagaaaaa tgttaacgtg tgcataaagt 1256401 gagagggagg caataagggt gcagaagctg aataaaaatg tgtacgatca ctatactcag 1256461 tatccagaaa aaattctcca attcggagaa ggaaactttc ttcggggatt tatcgattgg 1256521 cagattgatc aattgaatca acacactgat tttaatggga gcgtggcagt tgtccagcca 1256581 agaggctcag aaaaaatcaa acgattaaat gagcaagatg gattatatac acttttttta 1256641 caaggaatga aagacggaga agcggtaaac gagcatatga ttatcaactc aatcagccgg 1256701 ggaattgacc tgttttctga ttatgaagca tacaaagaat tggcatcaag cgaaaggctt 1256761 cggtttatta tctccaacac cactgaggct gggattgtat gtgatgaaaa agatcgttta 1256821 gaggataggc cgcaaaaaac attccctggg aaattaactg catttcttta ctttcgctat 1256881 caggctttta aaggagatca gacaaaaggg tgtgtcctga tcccatgtga actgatcgag 1256941 aataacggtg aaaagctgag ggaaacggtt cttcattatg cacatctgtg gaagctggag 1257001 gaaggattta cacagtggat tcatgaggcc aatacatttt gtaatagttt agtagaccgg 1257061 attgttccgg gttttcccgt cgacagcatt gatgagatca cggcagatct tggctatcag 1257121 gatgatttga tagttgtggg agagcaatat tatttgtggg ttatcgaggg gcctgattgg 1257181 attggaaaag aacttccctt tgcggctgca gggctgcata caaagatcgt cagcgacctc 1257241 accccatacc ggactaaaaa agtaagaatt ttaaatggcg ctcatacagc aatgacgcca 1257301 gtggctttat tatacggctt gaagactgtt agggatgcag tcgagcatcc ggaagtgggg 1257361 cgatttataa gagagctgat tgatgacgaa attcttcctg ttttaaaaat ggaaggtctt 1257421 tctcagtatg ctgacgatgt gctgaaccgt tttaaaaacc cgtatattaa gcattacctg 1257481 gaaagcattg cattgaacgc catttccaaa ttcaaaacga gaaacctgcc gactcttaag 1257541 gaatatgctg aacaaaaggg acagcttcct gaacgcttgg tgttttcttt cagcgctctt 1257601 ctgtattttt atcatgataa cgagacattg caggatgatc cggcagttct tcaatttttc 1257661 aaagaggttt ggtgtcagga ggatggcgac atgcttcgga ttgcatcaag agtgttaggc 1257721 gaacagcggc tgtggggggc agatctcaat gagataccga agctgactga tagagtcgct 1257781 gtttacttga atcatattca tgagctgggc atgcagaggg ctcttgaaca atactgcata 1257841 caagggggag aggtacgttg aagtcgttta taaagattca taagcaagat aatgtccttc 1257901 ttgctctgcg ggatattcaa aagggagaga ggctgcatgc ttacggcgtg tcgattgaag 1257961 taaaggatga tataaaaaga ggccataaga ttgcattgca gtctatcaaa gaaaacgaca 1258021 gcatcgtcaa gtacgggttt ccaatcggtc atgcatcaca agatatctcg atcggagagc 1258081 atattcatgt ccataatacg aaaacaaacc tgtctgatat ccaattatac agctatacac 1258141 cgagatttga tgaaaatccg tattctaatg agaaccggac gtttaaaggt tttagaagag 1258201 aaaacggaga tgcgggtgta cggaatgaat tgtggattgt cccaactgtc ggctgtgtca 1258261 atggaatagc agaaaaaatg ctgcagcgtt ttgtcagaga aacaggggat atcgctccat 1258321 ttgataacgt actggtgtta aagcatcaat acggatgctc gcagcttggc gacgatcatg 1258381 aaaatacgaa gcagatcctg ctgaatgcca ttcgccatcc aaatgccggc ggcgtcttgg 1258441 tgttagggct tggctgtgaa aacaatgagc tggcaagaat gaaggaagca ctgcaagatg 1258501 tgaacttgaa gcgggtgaag tttctggaat cccagtcggt gaccgacgaa atggaggcag 1258561 gcgttgcttt gctgaaggaa attcatgaag cggccaaagg agataagaga gaagacattc 1258621 cgctgtctga actgaagatc gggctgaaat gcggaggttc ggacggtttt tccggcataa 1258681 ccgcaaaccc gctgcttgga cgtttttcag attatctcat tgcacaggga gggagtactg 1258741 tgctgacgga agtaccggaa atgttcggcg cagaaaccat cctgatgcag cgggctgcca 1258801 atgaagaagt gtttcataag atagtcgatt taatcaatga tttcaaacaa tactttatta 1258861 aacatgatca gccggtgtac gaaaatcctt caccgggcaa caaagcgggc ggcatttcta 1258921 cacttgagga taaatcgctg ggctgtacgc aaaaagcggg gatttctcct gtcacggatg 1258981 tcttgaaata cggtgaagta ctcaagacaa aagggctgac tcttttgagc gcaccgggca 1259041 atgatttgat cgcctcctcc gcattggcgg ctgccggctg ccaaattgtc ctctttacaa 1259101 cgggaagagg cacgccgttt ggcacctttg tcccgacggt gaaagtagcg acaaacaccg 1259161 agctgtatga ggcgaagccg cattggattg attttaacgc aggcctttta gcagaggatg 1259221 atgttcatga ggaatatgtg ctgcgtgagt ttatccacta tatgattgag gtggcaagcg 1259281 gccagcttgt gaaccatgaa aaaaatgatt tcaaagaact cgccattttt aaatcgggtg 1259341 tgacgttata ataagaaaag gctatccttc aagcggatag ccttcttcat taaatcaatt 1259401 ttaaaccgct gactaaaata atggaagcca taataaattg cagtggacgc ggggagaatc 1259461 gaggcgaaag atggctcccg atcagtacgc cgggaattga accgaggagc agattagctg 1259521 ccagcatgta atccacgctt ccgaagcttg cgttcaaaat gcctgctgcc gtaacaagaa 1259581 gaaaagcatg cgcgatatcg gttccgacaa tctgtgacgc tttcatgtta aataagtaaa 1259641 tcatggcgat tgcaaataat gagccggacc cgattgatgt taatccgacg ataaacccaa 1259701 acacaacacc aataagaatt gtcagcgccc tcttattttc aagcggcatc agctgccagc 1259761 ggttggggcg aagttttcta tccaaaaaca aacgaacgat gattgaaatg gcaaccagcg 1259821 ttaacacata tcctagagcg tgcttaataa tttcttcctg atgctggtga aaggcgggga 1259881 acaaatgcaa tatgccaatg gctagcgaag cactcggaat accgccgatg gctaagtatt 1259941 ttaccaattt aaagttaatc gttttctgcc gccaatggga ggcaacgcca aacagctttg 1260001 tgatcgagtt atatacaaga tccgtaccga ccgcgatgga aggattaatt ccaagcacaa 1260061 ttaaaagggg agttaataag gccgctccac ccactcccgt caatccgact aaggctccga 1260121 caaacaaacc catcaatatg atgcttacac tcatgataaa ggcctcctga aaacccgact 1260181 agaattcacc cgaatcttat tcgcgttggt caagtattaa ttgtaagtgc tccatcggct 1260241 gctgaaaaac ccgagctcta tccgctccct gatggtatca ttcaattgac aacaccttat 1260301 acatcaggag aacacgtctt tcaggtgcaa cgagcacttg cggctctgta tttttaccct 1260361 gataaaggcg ctgttaacaa cggaattgac ggcgtttacg gaccgaaaac agctgacgca 1260421 gttgcccgtt ttcagtctgt taacggtcta actgctgacg gtatctacgg gcctgcgacg 1260481 aaagagaaga tcgcagcgca attaagctga tcaaagacca taaaaatccc ggagccgctc 1260541 cgggatttat tttttcttct tcaacttttt tataattcca gcactgcgct ccctcacccg 1260601 aagcgagtac ccggaaagcc caaaccttcc gtaatcaaca aacttcacac gcctcaccaa 1260661 ttttttcact gtatcacctg acattatcct ctgtttgtat ttattatatg tcacccttta 1260721 agaaaaggaa taaggacaag agctgttttc ccttgtcctt ttagtgtgat catgcttttt 1260781 ttcgtttata ctcgtcaatc agccgttcgt tttctttgaa gattcttgct gtatgcggac 1260841 tgacttgata gcttgcgaca ctggtggttg aacgtttttt caggatttta aacggcttcg 1260901 ccgctctggg ctcgcatctg ttttgaaacg cacgttccat tatccttcac cttcctcctc 1260961 aattggcagc accaaatcat atatgctcgt taatgacgta aatagcaaat aatcaaattc 1261021 cgtgacaatg ctgtcagacg tcagcttgat gacatagttc tgtgtctcga tggtaaaagg 1261081 gatgagaacc acttttccgt attggtcgta ataaacatcc tttcgatcga gccgtgtttg 1261141 tacatctgcc ggatcatcca tatgctcggt taaccggtct ttatcagcct gtgtcgaata 1261201 gtggcaaaga gaagccgtta agttcatttt atcagcatag gttttcagca gcttatcaat 1261261 accttcagca taagcatcta tacttccata ataaacatgg atcggttcgt ttttcaatag 1261321 gtattggtat gttttcagcc gattgagata catgtggagc atttcgttgt tttcttcaag 1261381 aatttctctt gtgtctgttt caagctcgct gccggccagt tttttgacat atgcacttaa 1261441 gaagataaaa gcatcaatca aagcaaaact gactgcgaca atgagatacc gttcccagtg 1261501 ggtaaatagg gaagtgggct catatgtcca gtataccata gcgcccagaa caaacagcaa 1261561 ataccaagtt ttccgaatgg cggacatttt ttctttgacc ttcgcttcga aacgccacgt 1261621 ggcatacacg tataacccca gtccggccac gatgcaccag accatgatct gaaagaataa 1261681 aaccatattc gaatccctca catctgaaat aggttctgct tattgtattc gagagatccg 1261741 gatggttttc ctgttccatc aaaaaaaccg ctcctttgac agaagcggtg tgacattaaa 1261801 atatcatatt taaaataaag taggcgatgg caccaagtgt cgctgaaatc ggaagcgtga 1261861 tgacccatgt aatgagcatt cgcttggccg taccccagtt tacgcctttt acgcggtggg 1261921 acgcaccgac gccaagaatt gatgaagaaa tgacgtgggt tgtactgacc ggcaaatgaa 1261981 taaacgtggc gccgaaaata atggctgctc cggttaagtc agcggaaaca ccgtttaccg 1262041 gacggatttt catgatcttt ccgccaacgg ttttgatgat tttccagccg ccgattgatg 1262101 ttccgagacc catggctgtc gcgcaggcga attgcaccca ggtaggaata tcattagcag 1262161 aagtatgtaa attcgctgtg atgagagcca ttgtgataat tcccattgct ttttgcgcat 1262221 cgtttgttcc gtgtgtatac gattgcaggg cagctgttac aatctgcact ctgcggaatt 1262281 gcttattcgt tttcgccaag ttgctgtctt tgaaaatcag cttaacgatg ctataaagaa 1262341 taaaaccaag gacaaaggca ataattggtg atagaatcag tgcttcaatg attttaatga 1262401 agcccttata gtttaacgct gcaaatccgg ctgccgcaat ggctgcaccg gcaatagcgc 1262461 cgatgatggc atgggatgag ctgcttggga taccgtagta ccatgtgata aggttccagg 1262521 caattgcagc gagtagcgca gccaaaatga caacagagcc attttccagc gtataaggat 1262581 ctacgatgtc tttcgtaatg gttttggcaa cacctgtaaa cgtcattgct ccgacaaagt 1262641 tcatcacagc agccaatata atggcatggc gcggttttaa cgcttttgtt gataccgaag 1262701 tcgcaattgc gtttgccgta tcatgaaacc cgttgatgaa atcaaacgcc agagcacaaa 1262761 tgactattag tatcgttaat attaatagaa tatccatttt tacccctcgt tacgcgtttt 1262821 tcataatgat ggtttcaaga ttattggcaa cactttgaca agagtcggcg atttcttcaa 1262881 gcgtttcgta tatttcacga tattgaatga ctttgattgg atctgtttca tttccgaaaa 1262941 gattctttaa tgattttctg tgcaagttgt cacaactgtg ctcatactct ttaattttga 1263001 ttgcgtgagg ctgaatatcc tttaagcgat tttctgccag cagctcgatc gtaatcaaaa 1263061 tctctttcgc acattctctg atatatccgc tgaatttatc aatatgctcg tctgatgaag 1263121 taattgagaa aatctccatc atggcagaga aatgttcgat tccgtcaagc acatcatcca 1263181 agctgtttgt cagctgaagg atatcttcgc gctcaatagg agtgatgaac gctttgttaa 1263241 gctctttaat catgacatga acatgattgt caccttttgt ttcatattcc tttaacgtat 1263301 ctgcaaattc tttaagagtc gtttggttag tgaccttaaa attcacaaaa tattctgcag 1263361 tttcgtctat gttctttgca atttctgtta aaaggagtga gaacttatct ttttttcttc 1263421 ttatcattaa aaaccctcca tagtttgaat gaacaatgca cacatcaaat tattatatag 1263481 ccttttgtcg aaaaaaaaca ggtaaagtcg aaaaaaacgt atcttgactt ttttgataaa 1263541 tcgtgtctcc ttattttgac ctacttcgct ttaaaaaaac gacccaagtt tgcaaaaact 1263601 ttctgcttaa cgtaaaaagt atatcaaaag ttgtgttttt cctgtcaact tttatcttct 1263661 gtttcaccaa aaaacggttc cctaaacaag ggaaccgttt tatcagcttg cttttcgttt 1263721 tttcatcccg taataaacag gcagtccggc aaggccgatg aggatggata atccgcagct 1263781 cattgtatct gtaatgagtg tgctgcctaa cacaaagaag gagcccgcga ttgccagaat 1263841 tggcataaat ggataaagcg gaacactgta ggcgcgcttt tctccctttg ctcgcttgcg 1263901 gagaataaac actgcaaaaa aggccatcac ataaaaaatg tagatcatga aaatggagat 1263961 ttctgagagc ttatcagggt tgctgatcag catcataatc aaagccaaag caatttgaaa 1264021 agaaatcgca atccatggtg tgcggaacga cgggtgtaca tgtgacagtt tttcagcaaa 1264081 tggaagctgt ttgcgttccg ccattgcaaa tgaaacacgc gggaaagaaa gcacctttcc 1264141 atttaagcac ccaaagatgc tgacgataat ccctacactg atcagctttc cgccaattga 1264201 accgaacagc atggttgcag cggtgcttgt cgcattttca ccaagcgtga caatttcgtt 1264261 cgctgacagg atgtgaagca atgcaaaatt aatgaaaata tagatcgccg ttacaattaa 1264321 taatccgccc gtcatagcgc gtggcagcag cttttcggga tttttcattt ctccgccgag 1264381 agcggcaagg agaatccatc cgtcataagc aaacaacgta gctaaaatag ccgccccgaa 1264441 gttcatatca gaaatgcttt cgtttactgc tgtgaagatg tgctgatcgc ctttccaaag 1264501 gccaaagacg atgatgcagg caatcggaat cagttttccg atcgttgtca gcgtttggac 1264561 aaaaccgccg tattttgtac cgataatatt aatgacgcat aaaaagagaa ctgctataat 1264621 tccaatgact tttgatagtc cagatcccca gccgaaaaga ttcgccatta aagatccaaa 1264681 atataaaccc agcgcgccaa taatcgccgg gccgtaaatg ataatctgca cccagccgca 1264741 caaaaatccc caaaactcgc cgtacacttc ttcaaggtac gtataaagcc cgccggtttt 1264801 tggaatctgc gttccgattt ccgcgattgt caaaccgccc gccagtgtta aaataccgcc 1264861 taacagccag gcgaaaagcg ccatttttga atcacctgaa taagcaagca cagcgccggg 1264921 cttcataaaa acaccagaac cgataatggt tccgatgaca agagtaaggg caaacaagag 1264981 gcctatctct tttttcaaac cgttgtcttc agtatgcatg tccttaacct cctatgatgt 1265041 tgaagcttca tgttgaagaa tctatttttt catattgtaa accctatttt agaaaagtga 1265101 aataaaataa attttctgat tttcgaaatt tgctttgtgt acagcagata aaactgtaga 1265161 aatacctgtt ttaatggtct ataaacgaat aaaattcata atttttattt acaaagttcg 1265221 tgttttatgt attaggattt tagccggtac agaggggaga tgagaattca gaaaatgaac 1265281 gaaccttcgg tgaagctgat atgttgactt tctcatgcga ataaaatact ttgttattag 1265341 aacaataaat atacaattat gatatgatat ctcgaaatcg agataaaata acctggaggg 1265401 acagcatatg aaagttaacg gcattcacca cgtatcggca ttaacggccg acgcacaaaa 1265461 aaacttggat ttctataaga aagtattagg attaaagctc gtcaaaaaat ccgtcaatca 1265521 ggatgaaccg acaatgtacc atctgttcta cggagatgaa gtggcaaacc cgggaactga 1265581 gctgacgttt ttcgagattc cccgcattgc accgtttcat gcgggaacaa acagtatttc 1265641 ttctattgga ttgcgcgttc caggcacaga agccctgcat tactggaaag aacgttttga 1265701 agagcagcaa gtaacgcaca gcggcatctc caaaagagcc ggacgtgaca tattggcatt 1265761 tcaagatcat gaggggcagc gacttgtgct gactgctgat gaggaaggaa aaggatatgg 1265821 cctgcctgtt aaacagagcg gcattccgga agaattttcg tttcgcgggt tagggccggt 1265881 tgaactgact gtgccatatg ctgaaccaac tttacacgta ttgacgaata ttcttggatt 1265941 tacagaaatc agccgtgaac cagtcgaagg gcaaggaacc gccgttattc tggaatcagg 1266001 agaaggcggt gctgcaacgg aaatccattt aatagaaaga aacgatcttc cgcgagagcg 1266061 tcaaggcaaa gggagtgttc accacgtcgc atttcgggta agagatgaag aagaacttgc 1266121 cgggtggcac cggatcatca gccgcgaagg ctttagcaat tcaggcatag ttgagcgcta 1266181 ctatttcaag gcgctgtatt tcagagaacc gaacggcatt ttgttcgagt tatcaacaga 1266241 cggaccgggc tttatggtag atgaaaatct tgatgagctt ggccaaacga ttgctcttcc 1266301 gccatatcta gagcatcgaa gagcagaaat tgaagcaaaa ttgaaaccga tccaataaat 1266361 tgtgattctt ttgccttccg gcgccgccgg agggcttttt ttattaccat aattaatttt 1266421 gacctaaaca gcatgcctta ttagggagga aatatcagat gctgattggg agaaatggct 1266481 taaaaccctt tgcaaatatg ggtgattggt atggaatggc ctcggcaaaa atattgtctt 1266541 tgtttattaa tagtttattc atatttgctt gttacactat ttcaaagtta gacaaaaagg 1266601 agtgaaaaat aagtggaaaa gaaaaaacgc gagctggata tcgtcctcct cctcattttg 1266661 ctcgcatctg cattcttaaa tatctataac atttggaagg acgacacggt gaatccttat 1266721 tacaccgcgg cagttacaag tatgatgcaa agctttcata atttctttta tgcttcgttc 1266781 gatgctgccg gctttataac agtagataaa ccgcctgtta cataccaaat ccaaacgatc 1266841 agcgcactga tattcggtat gcacggctgg agcgtcatcc tgcctcaggc acttgctggt 1266901 gtaggttctg tccttcttat gtacttgctg ataaagccga catttggaaa aacggcggcg 1266961 cgtattgcct catttgttat ggcatgtacg ccgatagctg tagctgtagc acgtacaaac 1267021 aatgttgatg cattactggt atttttctta ttgcttgcta catggcttct ctttaaagcg 1267081 atcagaaaag gaaagctgat ctggctgtta gcagcatttt tcgttgttgg agtaggtttt 1267141 aatacaaaaa tgctgcaggc ttacatgatt ttaccggctt tcttattgtt ctatctgatt 1267201 gcggcaaacg ccacaatcaa gaaaaaaatc gtttcattgg taagtgcgtt agccgtatta 1267261 gcagccgttt cgttatcgtg gccgctcatt gttgacaata tccctgcaag caagcggcct 1267321 tatatcggaa gcagccaaac caactctgtt ttggaattgg ctttcggcta taacggaatc 1267381 cagcggctga caggccaaaa ttcaggcggc ggccagggtg cgccaaacaa agacgcttca 1267441 aaagaaatgt cttcttctga taacactcaa gcaccgccta atcagtcatc aagcaacagc 1267501 tcatcaagcg atggtaaatc ctcaaatggc aatatggcgg cgcctccatc caatggccaa 1267561 atgccaagcg gcggtcaagg aggccctcca agcggcggag atggcggcca aggcggaccc 1267621 ggcggagacg gagggaaagg cggtacagga accggttcga aaatgcaatc aggttcaggg 1267681 atgtttggaa cgggaacacc tggtccactg cggcttttcc aacaagagtt atctgatcaa 1267741 atcagctggc ttctgccatt tgcgatattt ggaatcgcag gcttactgat cgctggcgca 1267801 agagaaagaa gaagattatc tgtagagcag aaggaaacgg tgttctgggt tgcgtggctt 1267861 gtaccgattg ccggattctt cagtgtcgca gaatttttcc atcattatta tctcatcatg 1267921 ctggcaccgc cgattgcggc tcttgtcggt gcggggtggg tcgctcttgt tcatctgtac 1267981 cgcaatcaga caggctggaa agcatggctt ttgccgggag caattattgc gacaactgga 1268041 tttgaattgt ttattctcag aaactacaac gatcaaatcg gtgttggatg gagtatcggg 1268101 gtaggtgtta tcggcgtgtt gtcagcgatt gctttgctgc tgtttaaaca gcgccaaaaa 1268161 ccgttcagtt attatgtttc acttgcagct ctcctcgcat tgctggtgat gccgatgtat 1268221 tgggcaagta caccgcttct gtacggaggc aacagctcac tgcctgaaac aggccctcaa 1268281 ctcgcatcaa tgagcggaaa aggcatggga atgtctgatg cgactgtaaa tgaaaaactg 1268341 atcaaatatc tagaggagaa taactccgga gctgaatacc tattcgccac aaccgattcg 1268401 aacacagcgg caccatatat cattaaaacg aaaaaagctg tcatggctat tggtggatac 1268461 agcggttctg acccggcaat cacactgact caattcaaaa aacttgtaaa agaaggaaaa 1268521 gtgaaatact tcttggcttc tggaatggga agaggcggaa acaatgacat tgttgaatgg 1268581 gttgagaaaa atggaaaaga agtagcatca gaaaaatggc aatcaagttc tgatcaaaaa 1268641 acagaaaata ctgattcagc tgatacatca agcagcaagg cttcaggtga aaacggcaaa 1268701 atgggcggac ctggcggaat gaatcagtca gcaacattat acgaactaca tgctgatgaa 1268761 taggaggcaa aaacatgagc agacatattc aatattcaat tgttgtacct gtgtataatg 1268821 aagagcttgt cattcatgaa acctatcagc gcttaaaaga ggtcatggat caaacgaagg 1268881 aaaactacga gctgcttttt gtcaacgatg gcagcaaaga ccgcagtatt gagattttaa 1268941 gagagcacag cctgatcgat ccgagagtga aaattattga tttttcaagg aattttggac 1269001 atcagatcgc cattacggca ggtatggatt atgcacaggg gaatgcaatc gtcgtcattg 1269061 acgccgattt gcaggaccct cctgaactga ttttagaaat gattgaaaag tggaaggaag 1269121 gctatgaagt cgtgtacgcc gtacggacta aacgaaaagg ggaaaccttt ttcaaaaaac 1269181 aaaccgcggc tatgttttac cggcttctca gcggtatgac agatattgat atcccgattg 1269241 atacggggga ttttcgcctc atggacagaa aagtctgtga tgaaatgaag agattaaaag 1269301 aaaaaaatcc atttgtaaga gggctagtca gctgggtggg tttcaaacag acagcggtcg 1269361 agtatgtacg tgatgaaagg ctcgccggag aaacaaagta cccgctcaag aaaatgctga 1269421 agctgtcaat ggacggcatc acgacatttt cacataaacc gctgaagctg gcaagctatg 1269481 cggggatttt aatgtcaggt actggatttc tgtatatgtt tatcgtgctg tatctgaagc 1269541 tattcacaga cagcacgatt accggctggt catcacttat tgtgatccag ctcctgttca 1269601 gcggcattgt ccttctgatt ttgggcgtga ttggcgaata tatcggcaga atctacgatg 1269661 aagccaaaga caggccgctt tacatcgtcc aaaaatcgta tggaattgaa aataaaagac 1269721 tctatagaga ccagcatatg tcataacctc aaaccccctg tccgtaatgg acagggggtt 1269781 tttatgctct gagcacgatc taaagcaaaa gatgctgata gatatatgga aattgggtaa 1269841 agaagagatt gtgagcttgt actgcggttc agtcatgctg aaataaaaac agcaaaactt 1269901 aaagatttcg tcctcggctt tgctgcatgt cagctgttat attggggggc ttttaagaaa 1269961 cgcatgatta gagccgtacc agttatgttt aatagaatac tcgtacccaa tacaattccc 1270021 cacgtcaacg tcgattcaga gagaagaaag ctcagcaaaa gaaaagccaa tcctgcgcag 1270081 atcataccca gtcccacggt tttcatgttc atgcctccta gcaaacgatg tttctagcat 1270141 ctgatgtgaa tgatgtcaat ctgtatgata tacggatatc tcgtcagaaa gtttcataga 1270201 acaattaggt cttttatcta ataaaaagcc tcagaccgct tttacggcct gaggcattat 1270261 gtcttacgaa gttttctctt ctttttgatc cagtttaatt tttttcgtca tttctttgcc 1270321 gtttcggaga attttcactt caacggtatc accgatcttt gcgtctttat ataagatatt 1270381 gcgcaattca ctgcctgtat caatttcttt accttttagg ccgatgataa tatcctccgc 1270441 ttttaatccg gccttttcag caggagagcc tgaagcgacc tcacggatgt aaacgccttt 1270501 attcagctgg ctgccgaaca ggccgagtgt gccttcttgg taattttgcg gcacttgctc 1270561 tagatcaagc atgctgacac cgatatatgg acgttcaatt tgtcctttag acagcaattc 1270621 ttcagcaatc ggttttacgt cattgcttgg aatggcgaat ccgataccct caacatcatc 1270681 ctcactgatt ttcatactgt taatgccgac aattttgccg tctgtattta acaaaggacc 1270741 gccgctgtta cctggattaa ttgctgcgtc tgtctgaatg acgttaatgc tcgtttcgcc 1270801 ggctgatgta gacattgaaa ccgttctgtc cacgccgctt acaattcctt gtgttactgt 1270861 gcgggacagg tcttttccaa gcggatcccc aatcgcaata acggtctcgc ctgttctaag 1270921 atcagatgaa tcaccgaagt ttgccacttt tgtgacgtgg tcatcactga tttggaggac 1270981 ggctaaatca gttaacgagt cactgcctac cagctttgca gtaacctcag tgccgtcata 1271041 taaagatacc ttcagtgatg atgccccttc tacgacgtgg ttatttgtaa tgatataagc 1271101 cttgccattc tcttttttga aaatgacacc tgaccctgaa ccgctttctg tatcttcgct 1271161 ggaatcagaa gaactagagc cgaacaaaga gctgtttgat tgtgcctgaa gatttgtaat 1271221 accgacaatc gctggtgaaa ggtcttctac catatctgag attttagaag agtcctcgct 1271281 cttgaatgca gatgagctgc ttgagctttt tttagattca gaggaggtgc ttgttgctgt 1271341 aacagattgc gtttgctgct ggctggatga ttgttttgca gtgtcctgag aatcatggtc 1271401 accaagcggt gtaaacgtgt aaatgccaag agcaagactg ccgccgatca ctccgccaag 1271461 caacggtctg aaccatccga atcctcgttt tttcttctcc tgatcatgaa tgacattgcg 1271521 ggccgagtag gaggcgctct gatcgttctc tttcgttaaa aagacctcat tctcattacc 1271581 tttcgttctg ttttcatcac gatagttatc catcatgttc actccgtttc tctattttca 1271641 catgtctatt tatattgata ggtttatgac ttgagtttat cataaacaaa aactgtggga 1271701 taaaaatgaa aagattatgg gaaattgtga aaaagtgcgg aaaacggtac acttcatatt 1271761 gtatatgaaa ggactgagtc gatggaacag attggattga ttggatatgg cagcatggcg 1271821 gatatgatcg ctagacagct gttgaaacat gaacaaataa aagagaatga gctatttatt 1271881 gagacgagaa cgaaggggga gcggctgcgg gcactcatgt cagattatcc aaacgtatcg 1271941 gctgatccgt tggagaattg ggcaaatacg tgccaattga ttttgatatg cgtcccgcca 1272001 ctccatgtca tcgaaacaat gcgccgtctg tacccgtatg tgaacagaaa tactcacatc 1272061 gtatccatag ctgccggtgt gccgctgcgt cttttggagg cagaaacaga agccggtatc 1272121 tcacgtgtta ttcctgccat tacgtccgaa gcagaagccg gcatctcact tgtcgttcac 1272181 agtgaagcac tggctgcaga gaaaaaagaa cgtctgaatg aattgttatc ggttttcagc 1272241 cgtgtacggg aaatcaaaga atcgaattta gatgtggcca gcaatttaac gagctcggca 1272301 ccgggattca tagctgcaat ctttgaagaa ctggcactgt ctgccgtcag aaacagcagc 1272361 ctgtccaaag aagaagcctt tgattttctg attcattcgc tatacggaac tggcaagatg 1272421 ctgatcgaaa aaaatatgtc tttcgaggag acgctggaac gtgttgcaac caaaggcgga 1272481 ataacgggag agggagctga ggtgatacac gcctctgtgc cggacgtttt tgatgaggta 1272541 tttgaaagaa ccctgagaaa atatgaactg cttacagaac aggttggtaa acaaacatga 1272601 atccttgaaa gaggattctt tttttatcac tgaatgattg agatttttcc cagttatatt 1272661 gcatttttcc tcttttttta atataatttg ttagaatatt cataatttag taaaaaagga 1272721 ggagcgttat gaaattgtac atgtcagtag atatggaagg tatttcgggt cttccggacg 1272781 atacctttgt ggattccggc aagcggaatt atgaacgcgg acggcttatc atgactgaag 1272841 aagcaaacta ctgtattgct gaagcgttta acagcgggtg taccgaggtg ctggtcaatg 1272901 acagtcattc gaagatgaat aatctgatgg ttgaaaagct tcaccctgaa gcagacttga 1272961 tttctggtga cgtcaaacca ttttcaatgg tggagggact ggatgatacg tttagaggcg 1273021 ctttgtttct cggttatcat gcgagagcct cgactcctgg tgtcatgtca cacagcatga 1273081 ttttcggcgt ccgtcatttt tacataaacg atcggcctgt cggtgagctt ggattaaatg 1273141 catacgttgc cggttattat gatgtcccgg tattaatggt agccggggat gaccgggcgg 1273201 cgaaggaagc agaagagctt atcccgaacg tgacgacagc cgcagtcaaa caaaccattt 1273261 caagatccgc agtgaagtgc ttgtcgcctg cgaaagccgg acggctgttg acagaaaaaa 1273321 ccgcatttgc cctgcaaaac aaggacaaag tcaagccgct cacaccgcct gacaggccag 1273381 ttctgagcat tgaattcgcc aattatggcc aagcagaatg ggcgaatctg atgccgggaa 1273441 cggaaatcaa gacgggaact acaaccgttc aatttcaggc gaaggacatg cttgaagcct 1273501 atcaggcgat gcttgtcatg actgagcttg cgatgcggac atcattctgc taaaggggtg 1273561 ttttaggctt tggcgcgata catgataaag cgtttttggg caatggcagc tacgattttg 1273621 gtgattacca ccctgacttt tgttctcatg aaggtcattc ccggatctcc ttttaacgag 1273681 gagagaggca caaatgaagc cgttcaaaaa aatctcgaag cctactatca cttagacgat 1273741 cctctcattt tccaatacat tttctactta aaatccatca ttacattcga tttcggacct 1273801 tcaattaaaa aaccgtcgga cagcgtaaat gatatgctgg aacgcggatt tcccgtttcc 1273861 tttgagcttg ggatgacagc gattgtcatt gctgtgattt ctgggctggt gctgggcgta 1273921 atcgctgcac tccgccgcaa tggctttttg gactacgccg cgatgagtct tgcagtactc 1273981 ggcatctcca tcccgaattt tattctggca acattgctca ttcagcaatt tgctgtcaat 1274041 ctcaaactat ttcccgctgc gacatggacg agcccgattc atatggtgct tccgaccgca 1274101 gcgcttgctg tagggccaat ggcgatcatt gccaggctga cacggtcgag catggtcgaa 1274161 gttctgacac aggattatat ccgcacagca aaagcaaaag ggctttctcc gttcaaaatt 1274221 atcgtaaaac acgcactcag aaatgcactc atgcccgtca ttaccgtcct gggcacactc 1274281 gtcgccagca tcttaacagg aagctttgtc attgaaaaaa tctttgccat tccgggaatg 1274341 ggaaaatatt ttgttgaaag cattaatcag cgggactacc ccgtgattat gggaacgacc 1274401 gttttttaca gcgtcattct gattatcatg ctgtttttgg tcgatttggc ctacggtctc 1274461 ttagacccgc gcattaaact gcataagaaa gggtgaagcg tgtgaatctc cctgtacaaa 1274521 cggatgaacg ccagccagaa cagcacaatc aggtgcctga tgagtggttt gtcttgaatc 1274581 aggaaaaaaa tcgggaagcc gattcggtca agcggccgag tttgtcatac acgcaggatg 1274641 cctggaggag gctgaaaaaa aataaattag cgatggccgg actctttatt cttttatttc 1274701 tttttgtcat ggcagttatc gggccctttt tatcgcccca tagtgtcgta cgccaatcgc 1274761 tgacagaaca aaatcttccg ccctcagccg atcattggtt cggcaccgat gaactcggcc 1274821 gggatgtgtt tacccgaaca tggtatggcg cgagaatctc gttgtttgtc ggcgtgatgg 1274881 cagcactgat tgattttttg atcggtgtca tttacggagg cgttgccggc tataaaggcg 1274941 gcaggattga cagcattatg atgcggatta tcgaagtgct gtacggactg ccgtatctgc 1275001 ttgttgtcat tttgctgatg gtgctcatgg gaccgggact gggcacgatt attgtggcgc 1275061 tgactgtgac cgggtgggtc ggcatggcga gaattgtaag aggccaggtg cttcagatta 1275121 aaaattatga atatgtactc gcctcgaaaa cctttggcgc gaaaaccttt cgcatcatcc 1275181 ggaagaattt gctgccgaat actatgggag cgatcatcgt acaaatgaca ttaaccgtac 1275241 ctgccgccat attcgcagaa tcatttttaa gctttctcgg cctgggcata caggctccgt 1275301 ttgcaagttg gggcgtgatg gcgaatgacg gcctgcctac gattttatct gggcattggt 1275361 ggcgcctgtt ttttccggcc tttttcatat ctctgacgat gtacgcgttt aatgtgctgg 1275421 gggacggatt gcaggatgcg cttgacccta agctgaggag gtagctgtat ggaaaaagtt 1275481 ctgtcagtcc aaaatctgca cgtgtctttt acgacttacg gcgggacggt tcaggcggtc 1275541 agaggggtga gctttgattt gtataaagga gaaacctttg cgatcgtcgg cgaatccggc 1275601 tgcggcaaaa gcgttacctc ccaaagcatc atgggcctgc ttccgcctta ttcggcgaag 1275661 gtgacagacg gcaggattct atttaaaaac aaagaccttt gccgtctctc tgacaaagaa 1275721 atgagaggta taaggggagc cgacatttct atgatttttc aagacccgat gacggcgtta 1275781 aaccctacgc tgactgtcgg cgaccagctg ggggaagcgc tattgcgcca caaaaaaatg 1275841 agcaaaaaag cggcacggaa agaggtgctt tccatgctgt cattggttgg tattccagat 1275901 cccggagagc gcctaaagca atatccccac caattcagcg gcggtatgag acagcggatt 1275961 gtcattgcga tggcgctgat ttgcgagcct gatatcttaa ttgcggatga accgaccacc 1276021 gccctggatg taaccattca ggcacagatt ttagagctgt ttaaagagat tcagagaaaa 1276081 acggatgtgt ctgtcattct gattacgcac gatttagggg ttgttgccca ggtagctgac 1276141 agagtcgcag tcatgtatgc cgggaaaatg gcggaaatcg gcacaagaaa agatattttt 1276201 tatcagccgc agcacccata tacaaaaggc ctgctgggct ctgtcccgcg gctggattta 1276261 aatggcgctg agctgacccc gattgacgga acgccgccgg atttattttc gcctccgccg 1276321 ggctgcccgt ttgccgcccg ctgtccgaac aggatggttg tgtgtgacag ggtgtacccg 1276381 ggccagacga tcagatctga ctcgcacacc gtcaactgct ggctgcagga tcaacgagca 1276441 gagcatgcgg tgctgtcagg agatgcgaag gattgaacat gaaaaggggg aagaggatga 1276501 aacgagtgaa aaagctatgg ggcatgggtc ttgcattagg actttcgttt gcgctgatgg 1276561 ggtgcacagc aaatgaacag gccggaaaag aaggcagtca tgataaggca aaaaccagcg 1276621 gagaaaaggt gctgtatgta aataatgaaa atgaaccgac ttcattcgat ccgccgatcg 1276681 gctttaataa tgtgtcatgg cagccgttaa ataacatcat ggaggggctg acgcgtcttg 1276741 gcaaagatca tgagcccgag ccggcaatgg cggagaaatg gtctgtttcg aaagataata 1276801 aaacttacac atttacgatt cgggaaaatg cgaaatggac aaacggagat cctgtaacag 1276861 ccggagactt cgaatacgcg tggaagcgga tgcttgatcc gaaaaaaggc gcttcatcgg 1276921 cattcctagg ttattttatt gaaggcggcg aagcatataa cagcgggaaa gggaaaaaag 1276981 acgatgtgaa ggtgacggca aaggatgatc gaacccttga agttacactg gaagcaccgc 1277041 aaaaatattt cctgagcgtt gtgtccaatc ccgcgtattt cccggtaaat gaaaaggtcg 1277101 ataaagacaa tccaaagtgg tttgctgagt cggatacatt tgtcggaaac ggcccgttta 1277161 agctgacgga atggaagcat gatgacagca tcacaatgga gaaaagcgac acgtattggg 1277221 ataaggatac agtgaagctt gataaggtga aatgggcgat ggtcagtgac agaaatacag 1277281 attaccagat gtttcaatca ggggaacttg ataccgctta tgtccctgct gagctgagtg 1277341 atcagctgct tgatcaggat aacgtcaata ttgttgacca ggcgggtctc tatttctatc 1277401 gatttaatgt caacatggag ccgttccaaa atgaaaacat cagaaaagcc tttgcgatgg 1277461 ctgtggatca agaggaaatt gtaaagtacg tcacgaaaaa taatgaaaaa ccggcgcacg 1277521 cctttgtatc gcctgggttt acgcagcctg acggcaaaga tttccgtgaa gcaggcggag 1277581 acctgatcaa gcctaacgaa agcaaagcga agcagctgct cgaaaagggc atgaaggaag 1277641 aaaactataa taagcttcct gcgatcacgc ttacttacag cacaaagccg gagcataaaa 1277701 agattgccga agctattcag caaaaattga aaaatagcct tggagtcgat gtgaagctgg 1277761 ccaatatgga atggaacgta tttttagagg atcaaaaagc gctgaaattc caattctctc 1277821 aaagctcatt tttgcctgat tatgcagacc ctatcagttt tctggaagcc tttcaaacgg 1277881 gaaattcgat gaaccgcaca ggctgggcca ataaagaata cgatcagctg atcaaacagg 1277941 cgaaaaacga agccgatgaa aaaacacggt tctctcttat gcatcaagct gaagagctgc 1278001 tcatcaatga agcgccgatc attccggttt atttttataa tcaggttcac ctgcaaaatg 1278061 aacaagtaaa aggaattgtc cgtcaccctg tcggctatat cgatttaaaa tgggcagata 1278121 aaaactgatg gaggcgattg aggaaatact gcttctttat gcgaaggagc ggtatttttt 1278181 ctctttcttg cacgtatacg tagggtgcag agcaaatgaa aggagtgttt tcgttgaatt 1278241 acaagccgaa agcgttgaac aagggtgata cagtcggagt gatcgcgccc gcaagtccgc 1278301 cggatccaaa aaagcttgac accgcgcttt tatttttaga agagctcggt cttcaggtga 1278361 agttgggcaa ggcgctgaaa aaccagcacg gctatttagc gggacaggat gatgagcggc 1278421 tggcggatct ccatgagatg ttcagagacg atgaggtaaa agcagtgttg tgcgcatgcg 1278481 ggggttttgg gacaggacgt atcgccgcgg gcattgattt cagcttgatc cgcaaacacc 1278541 ctaaaatctt ttggggatac agcgatatta cgtttttaca tactgccatt catcaaaaca 1278601 caggtcttgt cactttccat ggcccgatgc tcagcacgga tattggcctt gacgacgttc 1278661 acccgctgac aaaagcgtca tataagcagc tcttccagga gacggaattc acctatacag 1278721 aagagctttc tccgctgacc gagcttgttc ctggaaaagc ggaaggcgag cttgtcgggg 1278781 gaaatctgtc tttgctgacg tctacactgg gcacgccatt tgaaattgat acgagaggaa 1278841 agcttctgtt tattgaagat attgacgagg agccttatca aatcgaccgg atgctgaatc 1278901 agctgaaaat gggggggaag ctgacggacg cggcgggaat tctagtttgt gattttcaca 1278961 attgtgtccc ggtgaagcga gagaagtctc tctcgcttga gcaggtgctg gaagactata 1279021 ttatttctgc gggcaggcct gctctgagag gatttaaaat cggccactgc tcgccaagta 1279081 ttgccgttcc gatcggtgcg aaagctgcta tgaatacagc agaaaaaaca gccgtaatag 1279141 aggcgggcgt ttcagaaggg gcgctgaaga catgaaaatc attcgaatcg aaacaagccg 1279201 aatcgctgtc ccgctgacaa agccgtttaa aaccgcactt cgcactgtgt atacggctga 1279261 atcagtcata gtaaggatta cttatgacag cggtgcagtc ggatggggag aagcaccccc 1279321 gacgttagtg attacaggag acagcatgga tagcattgaa agtgccatcc accatgtgtt 1279381 gaagccggca ttgcttggaa aaagcctggc gggctatgag gccattctgc acgacatcca 1279441 gcatcttctt acaggaaata tgagcgcgaa ggctgctgta gaaatggctc tatacgacgg 1279501 ctgggcgcag atgtgcgggc tgccgcttta tcaaatgctt ggcggatatc gagatacgct 1279561 ggaaacagat tatactgtca gtgtcaactc acctgaagag atggcagctg atgccgagaa 1279621 ttatctcaaa caaggctttc aaacgctgaa aataaaggtc ggaaaagatg atattgcaac 1279681 agatatcgcc cgtatccagg aaatcagaaa acgtgtcgga tcagctgtga aactgcgttt 1279741 agacgctaat caggggtgga ggccgaagga agcggtaact gccattcgga aaatggagga 1279801 tgcgggccta ggcattgagc ttgtcgagca gcctgtccat aaagatgatc tcgctgggct 1279861 taaaaaggtg acagatgcaa cagatacgcc gattatggct gatgaaagtg tttttacacc 1279921 gcgccaggcg ttcgaagttc tgcaaacccg gagcgcagac ttgatcaata ttaaattgat 1279981 gaaagcgggc ggcatcagcg gagcagagaa aattaatgcc atggcggagg cctgcggggt 1280041 ggagtgtatg gtcggcagca tgatcgaaac gaagctgggc attacggccg cggcgcattt 1280101 tgcggcaagc aagagaaaca tcacacgctt tgattttgac gcgccgctga tgctgaaaac 1280161 agatgtattc aatggcggca taacatatag cggcagcacg atttcgatgc ctggcaaacc 1280221 gggcctcgga atcatcgggg ctgcgctttt gaaaggggaa aaagagcaat gatgcacact 1280281 gtcatatcag cagtggccaa catctggaca gcgcctgatt cacctcgtcc gtctgatcaa 1280341 ttcatgcttc aaccgactgt aatgatcaga gactggctgg agcgcatgac gtatgatgaa 1280401 cggcttggat tatgtacaga caatgtaatc caaactcagg ttctctttgg cgaaaaggta 1280461 cttgtgacgg cggaacaggg ggaatgggtt tctgtgatcg tgcctagcca gccatcccga 1280521 aaggatccgc gcggataccc gggctggatg aaaaagtacc agctggaaaa aacaaagccc 1280581 atccatacac aacacgatgt gatgatcagc aaacctgctg cctttttgta cagaagcaat 1280641 ggggaaaagg agatcgaatt aagctttttg acagttctgc cccttattgc aaaagaaaac 1280701 ggatatttta aggtttcgac cgtttttggg gaaaggtttg tgaggcaaag tgatgcagtg 1280761 cctgtcagcc aacagaaagg gactgctgaa gacatcattc aaacgggtgc gttttttctt 1280821 ggccttccct acctgtgggg agggatcagc gggtttgggt ttgattgctc cggatttatg 1280881 tacagtatat ttaaggcgaa tggatacagc atcccccgtg atgcgggaga tcaggctaag 1280941 gcagggaagg gtgtcccgct tgatgatatg aaagccggtg atctgctgtt ttttgcttat 1281001 gaggaaggaa aaggagcgat tcatcacgtc ggtctgtatg taggcggcgg gaaaatgctt 1281061 cattctccaa agacagggaa gtcaatcgaa atcctcacat taacagagac aatctatgaa 1281121 aaagaattat gtgcggtgcg ccgctgtttt tcagaataag gagggagaca aatgaggcga 1281181 ctgcctttgt tagaggtcag ccagctgaaa atgcattttg acgcagggaa aaagcggaca 1281241 gtcaaagctg tcgacggggt cacctttcag attcgtgaag gagaaacgtt cgggctagtc 1281301 ggggaatcag ggtgcgggaa atcaaccttg gggagagtgc tgatgcgcct ttatcagccg 1281361 acagaaggaa gcgtgacata ccgcggcaca aatcttcatg cactaagtga aaaagagcag 1281421 tttgccttca accgcaaact gcagatgatt tttcaggacc cttatgcttc acttaacccg 1281481 cgcatgaccg ttcgagaaat tattttggag ccgatggaga ttcataatct ctacaatacc 1281541 cataaagcac ggcttctcgt cgtggacgag ctgcttgagg cagttgggct tcaccccgat 1281601 tttggcagcc gttatccgca tgaattcagc ggcgggcaaa ggcagagaat cgggattgcg 1281661 agagcactgt cgctgaatcc tgaatttatc gtggcggacg aaccgatttc tgcacttgat 1281721 gtctctgttc aagcgcaggt ggtcaacctg ctgaagcggc ttcaaaaaga gaaagggctt 1281781 acgtttttat tcattgccca tgatctttcg atggtgaagc atatcagtga caggatcggt 1281841 gttatgtact taggacacat gatggaaatt acagagagcg gcaccttgta tcgtgaaccg 1281901 ctccatccct atacaaaggc gcttttgtcc tcgattccga ttccagatcc tgaattggag 1281961 gacaagcgtg agcgtattct cttgaaaggg gagctgccga gcccggtcaa tccgccaagc 1282021 ggctgcgtgt ttcgtacccg ctgtccggag gcgatgcctg aatgtggaga atctcgtccc 1282081 cagcttcaag aaatcgaacc cggccgtttt gtcgcttgcc atttgtatcg aaatgctgaa 1282141 acgaaggaaa aagtaagata aataaaaaga gtggctcctt tttactagag ccactccatt 1282201 tgtttatact tgatgtaaaa actttacaca aaccgggtaa gggacagaaa ccgttgatgg 1282261 gaggagtgtc aatcggccgg tttctttgtc tctttcaaac aagacaaggt tgcctgtttc 1282321 ttcatttgaa gcaacgagga acccttccgt tgggtcaaat acaaagtcac gaggccagtt 1282381 tccttctgtc gacactcttt ctacgaaagc cagctctcct gaatattgat tcacttcaaa 1282441 tacggcgata ctgtcatggc cgcggtttgc gacataaaca aaacgtccgt cctgcgtgac 1282501 atgtattgcg cttccctggc tgttatctgt aaaatcatca gggatggcag aaacgacttg 1282561 gatttctcta aattcgccgg ctgtcgggtt gtattcaagc gcaatcactt cattgcttaa 1282621 ttctgtcatg acataagcgt atttttcttt cggatgaaaa gcgatatggc gaggtcctgc 1282681 accgggagcg aaggaatggc ttccggattc agtcaacaca ccgtctttaa gcttataggt 1282741 gtagagctta tctataccta aatcaaccgc taccacataa ttgtgttcag gtgtgaaccc 1282801 cgcgtagtgt gtatgcggtt tttcttgtct ttcgtgcggc ccttttcctg tgtgagcggc 1282861 ctctgaaaca ggtgattgca agctgccgtc ttcctgaacc ggaaaaacgt gtaccttccc 1282921 gctgtgataa ttggcagtca gtacgaattg attttgatca tcaacgctta cgtggcatgg 1282981 cgaagggcca tcaattaact gatgattcag aaatgtcaat tcgccgctgt ttttatcgat 1283041 ttgataggca gcaactccgc cttggccgtc tgctttttcg atggaataaa ggatggtgtt 1283101 gtttttattc gtcgccacat atgtcgggtt gcccagctta gcggccagct ttggctcgct 1283161 gagtgctttt ttctcagtat caagctcaaa tgaataaatt ccttcgcttc cgccttttgt 1283221 atatgttccc acatatccta tgtattttgt catgcgattt cccccttaaa aatgatgtca 1283281 cctctatatt aacgtatctt gataaaataa gctgttcaaa acatgaaaaa ggggaagatt 1283341 cttcattcgc ctcgaatcag cggcattgtg cagcacctga aggagccgcc tgatttaata 1283401 atttctgaca ggtcaatttc gataatgtga tagcctcttt tcgatagctg ttgattgaca 1283461 tggcggttgc cagggagact gatgatcgtt ttttttccga ttgaaaggac gttggtgcca 1283521 agcgtaaatt gttcgtcctc gggcacctca ataagatcat aacgttttgc cagcatatcg 1283581 gctgcatctg gctcaatggc ctgtgaataa attaacgctt cgctttcaga tataatgtta 1283641 aatacgcagt ccaaatgcaa aaatttttca tgaagcttca ctggaacgat cgtatattca 1283701 ggaagtgcct cttctagctg gccgatagct gaaatgtcgg tgcgctggct gattccgaca 1283761 tagacaatgt catcatcgat aatgacgtct ccgccttcaa tactcgtatc aagcatgcgg 1283821 gtgtaagaga taccttggct gtgaaaaaaa tcttttataa cggcttcttc tccttggcga 1283881 atcggttcag tcatgcttga cagaaaggct ttttctccga tgacaaatcc tatgtcccta 1283941 gtaaaaacct gttctgggag tccgtcgcga acgggcaaaa ggacgacctc aacgttgtgt 1284001 gacctaagtg cctccactaa gcggctgtgc tggtcgttag cggtttttac atgaatattg 1284061 tcatcttcaa aatgtttttg tgtttcgttt ataacatctt ttatggtcat gtgctcaggt 1284121 ttgcataaga tcactttttg aagtgtgccg tattccgttc ggcataccgt tttgtgctga 1284181 gatttcggga tggatacgtc catttgtttt tcctcctaaa gtgtgaagaa tacatttatt 1284241 attccctcat catgaaaatc attaaaccat tttaaatttt agacaaatgg aagagaatat 1284301 tgtttaatag gagaatataa gtgcatttag ctaaaagatc agacatcaaa ggggagaaag 1284361 gtatggaaac accggaaaca agattttgta aagagtcaaa ggttgtgaaa accagcaggg 1284421 tgttcccgct tgacacgaac aaccataata cgctgtttgg cggaaaatta atgagctaca 1284481 tagacgacat tgcctctatt tcagcggcgc gccattgcag acgtgaaacg gtaacagctt 1284541 caatggattc tgtagatttt ttaaagccga tcgggcaaaa ggattctgtc tgcctagagt 1284601 catatgtgac atgggtcggc acatcttcca tggaagtatt tgtgaaagtt attaaggagc 1284661 atttgatgac tggcgaacgg gaactcgctg ccacatcctt tttgacattt gtcgcattag 1284721 attcaaatgg caagccggtg cctgtaccga gggttgtacc ggaaacagaa gaagaaatca 1284781 tgctgcataa tacagctgta cagcgtgcta atgaacgtaa gaaccgcaag agacacagcc 1284841 aggcgcttgc aaatgcgctc ggaactgata agccttggtg aacgttaaac ccaaaacata 1284901 agttgttttg ggtttttttg tacttttcaa tggtgattat tacaatggtt agtccgtttt 1284961 tgctagggga ttctataaaa aagcaacaaa tgtcatgtta aattgataat tttgtgacaa 1285021 ctttattaaa gattcatttt agatatatct tttattcgta agatcatgta ttttaaagat 1285081 atattttaaa tacatctttt cgaaaggatt gtttataaaa tgttagataa caaaacaatc 1285141 gaaattatta aaagcactgt acccgtattg caacagcatg gagaaacaat cactggccgt 1285201 ttttacgatc ggatgtttca agaccatcca gagcttttga acatttttaa tcaaacaaac 1285261 caaaagaaaa aaacacagcg aactgcactg gcaaatgccg ttattgcagc tgcggcaaac 1285321 attgaccaat taggaaacat cattccggtt gtcaaacaaa tcggccacaa gcaccgcagt 1285381 atcggaatta agcctgagca ctacccaatc gtcggtaaat atttgctgat tgcgattaaa 1285441 gatgtattgg gagacgctgc aactcctgac attatgcagg catgggaaaa agcgtacgga 1285501 gtcattgctg acgcgttcat cggaattgaa aaagacatgt atgaacaggc tgaagagcaa 1285561 gccggcggct ggaaggagta taagccattc gttatcgcaa aaaaagagcg ggaaagcaaa 1285621 gaaattacat ccttctattt gaaaccggaa gacagcaagc cgttacctga attccaagca 1285681 gggcaatata tcagcatcaa agtgcggatt cctgattctg aatatacgca tatccgccag 1285741 tacagcctgt ctgatatgcc gggaaaagac tattatcgaa tttcagtgaa gaaagatggt 1285801 gtcgtgtctt cctacttaca cgatgggctg caggagggag attcaataga gatcagcgca 1285861 ccggcagggg actttgtttt agatcatgca tcacaaaaag atctcgtttt gatcagtgcc 1285921 ggagttggca ttacaccaat gatcagcatg ctgaaaacat ctgtttccaa acagcctgaa 1285981 cggcaaattc tgttcattca tgcggcgaaa aacagtgaat atcatgcatt gcgccatgaa 1286041 gtagaagaag cagcaaaaca ttctgctgtt aaaacagcat ttgtgtatcg cgagccgaca 1286101 gaggaagacc gtgcaggtga tctgcatttt catgaaggac agattgatca gcaattcctc 1286161 aaagaactga ttgccaacac agatgcggat tactatattt gcggttcacc gtcgtttatt 1286221 acggcaatgc ataagcttgt atcagagctc ggatcagcgc cggagtctat ccattacgag 1286281 ctattcggcc cgcaattaag tttggcgcag tccgtttgaa cacatacatg aaactcttct 1286341 cctttcagag aagagttttt tattgagata taagaaggca gacaagcgcc ggtttctaca 1286401 tccggacaat cacagacccg ctgccatttg tgcatacacg gttttgctgt tcttgcattg 1286461 ttctcagcaa ttcattgttt acctcaatcg ctctaattag ttgcttcatt cttagctcca 1286521 aaccggccag cctgtcgatt gtttgctgct ggtagccctc gggttgggga gccaatggca 1286581 gatcaaaggg ccaaagggta ttcgacttct gatttttcat attgcgtatt gcgcctccaa 1286641 tcggtgtcac tttctattat gttatgttca ggcgatatgc acgttcgcct agacactgat 1286701 gcatagaggg cctgccacgg ggcacaatag gctcaatatg accagcggat ggaggtaaag 1286761 atcggtgtta tggatggtat gggtattttt actgaagcca gttatcgtat tttcgattgc 1286821 atatattttg tttcggcttg ccggtaaaaa agctgtgtca caaatgaaca attttgacct 1286881 gcttttgacc ttcgcaatcg gaaccattat cagtgagccg atccttacat ccaagctgcc 1286941 gatgtcaatt tattatgcgg gtgctttttt ggtgctttat cttatcatga gcaagctctc 1287001 tttatctaat aaatggcgat ggctcctagt cgtgagcccg actgtcctaa tccgaaacgg 1287061 ggatattgat gaacgcggcc ttcgtaaaga aaggctgact gttaatgagc tgctcggaaa 1287121 gctgagggaa aagggctatg ccgacccggc tgacattgat cttgctatca ttgaagaaac 1287181 gggagaagta agcgtcatcc cgaaagagga agcgagagcg gtgcaggtgc gggatttgaa 1287241 tatggaagct gaacggaatt ttatcccgat tccgctcata ctggatggcg aaatccttga 1287301 tcataatttg aaatatctcc aaaaaaaccg atcctggctg tttgagaagc ttgaggaaaa 1287361 agggtacagc cccaaactgc tgtcttcgat tatccttggc acgatgaatg cacgcggtga 1287421 tatatccctt gatttaaata ccgctaatga accgcagcat gatccttact tatataaacc 1287481 gggaaataac aattaagatg gctctctctt gtaatgagag cttttttctt ttttaaaggg 1287541 aatttttgtt tggtgtcaaa tgtacctagt taggagggga actgaacatg aaggacttat 1287601 ccataagaaa cgacatggcg ccaacggtca gtttgctgta ttccgcagtg gaagaaaaca 1287661 gtctccgtct ggcttccatc gtaagccata tgacacacag tgaactttac tataaggggc 1287721 gctgccaaac aaaaaacagc acggctcagc ttttgcacca tatcacaaat gttgatatca 1287781 gatgggtctg gcgtatcaag gaaaatcgga tcccggacca tattgaacag gcatacggcc 1287841 cgatgacaga tgaaagcgga cggctgcctg aaccggtgaa tcagccagac ttagatgaac 1287901 tcctgaaaag acatcagcat gtagtagaga agctgaaatc ggtatgcttc actttaactg 1287961 aaaatgcttt gaaccagccg ctttccttcg aaggtgacac cgcgacgata cgatggggaa 1288021 tttggcatat ggcagatcat aaccgctatc atcaggcaca tattgaagct ctcaaaaaag 1288081 aatggaagca ggatgtggcg aagtatgaac gctaaaacga agcttgtgac tgatcgaatt 1288141 cgtttgcgct gtatggaaga tcgggatcaa gccactttgt ttgggctgct ttttaatgat 1288201 cctgacgtca tgacatatta ttccggttta aaagataaga ggcaaacccg cgagtgggtc 1288261 aattggaacc aacgaaatga aaaagggtac ggcgttagtc tgtggatcgc cgaagataag 1288321 cggacagggg agtttttggg gcaatgcggc atcgttcccc agcagatcga aaatcaaacc 1288381 gtaatggaaa ttggctatat gtttgcccgc cgccactggg ggaacggcta tgcgcaagaa 1288441 gcggctcggg cctgtctgga ctatggcttt aacgagcggc agttcggcaa aatggcggct 1288501 ttgattgatc cgggtaacaa agcgtccata cgggtagcgg agaaaatcgg catgcattac 1288561 agcaaaacga tcagaaaatg gaataaaccg atcgcggtat atgaaagaaa atcttacaat 1288621 tgaaagatag agctgagttt agtatcatga tatcatgtaa agttttctag ggttccgcat 1288681 gtcaattgac atggactggt ccgagagaaa acacatacgc gtaaatagaa gcgcgtatgc 1288741 acacggaggg aaaaaagccc gggagagtca atctcatgtg agacgactgt ccggggtttt 1288801 tttgttttcg gagaatctta atagatagaa aggaatgact caaaatgaaa tggggattgg 1288861 tcgtgcttgc cgctgttttc gaggttgttt gggtgatagg cttaaagcac gctgactcag 1288921 ccttaacatg gagcggcact gccatcggca tcatattcag cttttacctt ctaatgaagg 1288981 cgactcacag tctgcctgtt ggtaccgtgt atgccgtctt taccgggctc ggcacagcgg 1289041 gaacagtact tagtgaaatc gttctttttc atgaaccggt tggatggccg aagctattgt 1289101 taattggcgt gctcttaatc ggtgtaatcg ggttgaagct tgtgacacag gatgagacag 1289161 aggaaaaagg aggcgaggca taatgctgca ctggatcagt ttattgtgcg cgggctgttt 1289221 agaaatggcc ggcgtggccc ttatgaatca atatgcgaaa gaaaaaagcg tgaaatgggt 1289281 gctgttgatc attgttggtt ttgccgcttc attttccttg ctgtcgtacg caatggaaac 1289341 cactccgatg ggaacggctt acgcggtctg gacaggaatt ggcaccgccg gcggggcgct 1289401 tatcggcatc ctcttttaca aggagcagaa agacgccaaa cggatcttct ttatcgcgtt 1289461 gattttatgc tcagcagttg gtttaaaaat tctgtcataa attgattttt atcaaatctt 1289521 cagtataatg gataaatagt ttagacttac aaagataaga gggattattc atgaaatcat 1289581 atatgactca gcggttggac gaataccgtg acggaaatga ggataaaggt cggctcttgg 1289641 tcagctgccc cgatcagccg ggtatcgtct ctgcagtttc cgcgttttta tttgaacacg 1289701 gtgccaatat tatagaatca aatcaatata cgacagaccc tgaaggcggc cggttcttcc 1289761 tgagaatcga attcgactgc gcaggcattc gtgaaaaaaa atcatcactt caggcagcgt 1289821 ttgcctctgt tgcggaaaaa ttcgacatga catggagctt aactttggcg agcgaactga 1289881 agcgtgtcgc cattttcgtt tcaaaggagc tccactgcct gcatgagctg atttgggaat 1289941 ggcaaaccgg caacctgatg gcggagatcg ctgttgtcat cagtaaccat gaggaagcga 1290001 gagagctggt tgagcgcctg aacattccat tccactatat gaaagcgaac aaagacatca 1290061 gagcggaagt cgaaaagaag cagcttgaac tgctggagca gtacgatgtt gatgtgatcg 1290121 tgctcgcacg ctatatgcag attctaactc ctgattttgt ttcggctcat ccgaatcgca 1290181 tcatcaatat ccaccattca ttcctgccag cttttatcgg tgcgaatccg tacaaacggg 1290241 cctacgagcg cggcgtgaaa ctgatcggtg cgacatctca ttatgtgaca aacgatcttg 1290301 atgaagggcc gatcattgaa caggatattg agcgtgtgga ccaccgcgat aatgcggaag 1290361 cgctgaaaaa catcggaaga acaattgagc gcagcgtgct tgcccgtgct gtgaaatggc 1290421 atttggaaga ccgtgtcatc gttcatgaaa ataaaacaat cgtctttaac tagactgcaa 1290481 gaggcccgcg caatgcgggc tatttttgat gacaaaaaac cttgacaagt gtcttttttc 1290541 tttgcataat ataaaaaaat cattgagcgt tgaagaggat tagtaagcag acctttctgt 1290601 gacagagagc aaaatgaatc gctgaaacat tttgccgcat gaaacctgcc gaacctgcct 1290661 tggagtccta gggggaaaac ctaggcgcat aacctggcgt tacaggagag cggagcgtgc 1290721 acaagcgcgt tcaatcaagg tggtaccacg gaaacccatt tcgtccttat gaatcaggat 1290781 gaaatgggtt tttttattgt agaagagccg cggaggagaa taaatgaaaa aacaaagaat 1290841 agtagtgaaa ataggaagca gttcgctcac gaatagcaaa ggaagcattg atgaggcaaa 1290901 aatcagagag catgttcagg cgatttccgt gttaaaaaaa gcggggcatg aaatgattct 1290961 gattacctcg ggtgccgtag cggcggggtt ttccagcctc ggttatccat cccgtcccgt 1291021 taccatcaaa ggaaaacagg cggcggccgc ggtcggacaa acactgttaa tgcagcaata 1291081 tatgaatcaa tttaaacaat actcactgac tccgggacaa atccttttaa cgagaaatga 1291141 tttttcgaaa agagaacggt atcgaaacgc gtatgctacg ataatggaat tattagagcg 1291201 gggcgtcatt ccgattatca acgagaacga ttctacatct gttgaagaat tgacattcgg 1291261 agataatgat atgctttctg cgttagtcag cggattgatt cacgcggacc agctcatgat 1291321 tctcactgac attaacggac tgtatgatgc caatccaaat gaaaatcctg aggcgaaacg 1291381 atttgattat ttgccagaga tcacgcctga attgcttgga tatgcaggtt cagctggatc 1291441 aaaggtcggc accggcggaa tgaaatcaaa gctgttagcc acacaaaccg cgctgtctct 1291501 gggagtgaaa gtattcattg gaactggcag cggagagcaa aaacttgcgg acattttgga 1291561 cggcagggga gacggcactt atatcggaga caaagaacta tcttcggtta acaacacaag 1291621 gcagtggatt cagttccact cgccgatatc gggagaaatt atcattgatg cgggtgccga 1291681 agaggcgatg atccataatg gaagcagcct tttgcccgct ggagttgtgg gcgtgaacgg 1291741 aagctttccg aaaggggcgg ttgtggaagt caggggaccg ggcggcgtga tcggcaaagg 1291801 ccaaactcat tactcctccg aggagattat ggaggctaaa ggcaaacgca gtgacgaact 1291861 tgattttgag aaaacgtttg aggttattca taggaatgac tgggtcaatg taaaagacta 1291921 ggaggcggaa aaatgagtga agtttctgta aaagcgaagc tggcgaaaga agcagcagcc 1291981 gaaatgatca tgaaaacaac agccgagaag gatgaggcgc tcagcctcat tgcaaacgga 1292041 ctccgcaaag aactggattt tctcttggcg gagaatgcaa aagacattgt gaacggaaaa 1292101 gagaatggtt taacaccgga catcattgac cgtctctcat tggatgagaa acggatacgc 1292161 gatatcgcgg acgcggtgga gctcttaatc gacttagcgg acccaatcgg cgactctctt 1292221 gaaacgattg aaaaagaaaa cggcctgttt attgaaaaaa tccgtgtgcc gctcggtgtc 1292281 gtaggaatga tttatgaggc gaggccaaac gtcacagttg atgcggctac cctttgcctg 1292341 aagacaggga acgcggttgt gctgcgggga agctcctcag ccatccacag caacaaagcg 1292401 ctcgtcagtg tcatttacag agcacttgag caatcagcgc ttccgattca cgctgtgcag 1292461 ctgattgagg atacgagcag agagacagca aaagagctct ttacgttaaa tgatggctta 1292521 gacgtattga ttccgcgcgg aggcaagaaa ctgattgatc tcgttgtgag agaatcaaca 1292581 gttcctgtat tagaaacggg agcaggaaac tgccacatat tcattgacga aacagccaaa 1292641 ccgcaaatgg cagaaaaggt tgttgtaaat gccaaaacgc agcgcccttc tgtatgcaac 1292701 gcgattgaat cattgctgat tcacaaggct tgggcaagac agcacggaaa agaattgctg 1292761 gaccagctgg aaaacgcggg agttgaaatt cgcggtgatg aattggtatg tgaacttcat 1292821 ccttcaagca aacaagcatc aaaagaagat tgggaaaccg aatttttagc gcctgtcctc 1292881 agcgtaaaga cggttgaaaa cgtccaagaa gctgtaaagc atatccaaca atacggcacc 1292941 aatcattctg aagcgatttt aactgaaaat gacaaaaatg cggtatattt tcaaacggct 1293001 gtcgatgctg ccgctgtcta tcataacgcg tcaacccgct ttaccgacgg ctttgaattc 1293061 ggctacggag ccgaaatcgg catcagcacg caaaagcttc atgcaagagg accgatgggg 1293121 cttcctgcac tgacttctac aaaatacatc attaaaggaa ctgggcaaat ccgtgaatag 1293181 cggggtaatg ttcaatgaaa aagcttatct cattacgaga taagcttttt tatacgcgaa 1293241 aaattgacat ttcaaattta attgtgtaca atttaattgt ataaaatata ttgggggaat 1293301 gaaaaatgag tcagccatta tttaccgcaa ctgtttcagc ggtaggagga agagaaggaa 1293361 aggtcatttc atcagaccgc gttcttgagc ttgatgtcgc aatgccgggg acaccgagag 1293421 ccaagaaatt agaaaaagcg acaaatccag agcagctgtt tgcagcaggt tatgcagctt 1293481 gctttgacag cgccctgcag cttgtcgcaa gaacagaacg ggtaaaagta gagacagagg 1293541 ttacagcaaa tgttagcctg ttaaaggatg aagcggacca gggctataag ctgggtgtga 1293601 cgctgcaagt aaaaggagaa ggagtcagtg catcagaatt ggaggcgctt gtgaaaaaag 1293661 cgcacggcgt ctgcccgtac tcaaaagcaa cctccggaaa tattgatgtg acacttgaag 1293721 ttgctgaata aataaaaaga ggatgcctgt acaaggcatc ctcaattttt ttgatgaagt 1293781 gtttccagta atgtatatag agcggacttt aactgtttga gatcctcccc agactgcttt 1293841 gagagcccca gaattgtccc tggaatgtca accgcttttt cttttaataa cgctccgtcc 1293901 tctgtcaggc tgatcaacac ggaccgctca tcctcttcag atctttttct cgtaatcaaa 1293961 ccctgttgtt ccattcgttt aagcatcgga gtgagcgttc ctgaatctaa atacagctgt 1294021 tcgcccattt ttttgacagt aagcgtttca tgttcccata acaaaagcaa agccaaatat 1294081 tgagggtatg ttatattcag cttatcaagc agcggcttgt attgctttgt catctcccgc 1294141 gaactcgcat atagcaaaaa acaaagctga ttctccaatt tcatatgatc aaatttattt 1294201 tccattttgt tcaccaactc ttttttgtca ttcgattcta ttgtatctga aaaacctcac 1294261 ttttcctatt ctcggcaaac atagcatgtt taaaaagatc agaaagggaa atataacaac 1294321 tagatacaaa taaggaggtt gggaaatatg gcactattta cagcaaaagt aaccgcgcga 1294381 ggcggacgag caggacatat tacatcagat gacggtgttc ttgattttga tattgtcatg 1294441 ccaaatgcca aaaaagaagg acaaaccggc acaaatccgg aacagctctt tgcggcaggg 1294501 tatgctgcat gcttcggcgg cgcgctcgaa cacgtagcca aagagcagaa tatcgaaatt 1294561 gattcggaga ttgaagggca ggtcagcctc atgaaggatg agagcgacgg cgggtttaaa 1294621 atcggtgtca cacttgttgt gaacacgaaa gatttagatc gggaaaaggc acaagagctt 1294681 gtcaacgccg ctcatgaatt ctgtccttac tcaaaggcaa ccagaggaaa tgttgatgta 1294741 aaactagaat taaaataatg accggcatcc tgaggattct caggatgttt tttggtgtcg 1294801 gacatgcggg gcgggcacag atttatgata aaacttcaga gaagcgtttg aagcatgcct 1294861 ttaaaccaaa agttacagat gaagcgggtg gctggcacgg tgtctgccgt gctgaattgc 1294921 gcgtatatgc tgttttgtat ttgcacaggg catagcggct acttggagaa ataacaagga 1294981 ccaggccgcg catgcctgat ccttttaata ttctttctta ttggcgaagt tccgccatgc 1295041 ttgaaacggg gataaatgct ctgttagtgt cacttgataa aaggggatcg ttctttcttc 1295101 agcaggttta tcaatttctt tataaatgaa tgaatcatca aacccggctt cggcagcgtc 1295161 tgtgtgctca gctgcataga aaacggcttt aggccgggcc cagtagatgg cgcccaagca 1295221 cattgggcat ggttcacagc tcgtatacaa aatgcagtca tcaagctggt aggctcctag 1295281 caccttacag gctttccgaa tagctgtgac ttccgcgtgg gcagtcggat cattgcttgt 1295341 tgtgacgttg ttctgtccct ctgcaataat ggctccgtct ttcacgataa cggctccaaa 1295401 aggcccgccg attcctgcat tcactccttc acatgcgaga gtgacagccc gttttaagaa 1295461 cgtttcatga ttcatcccaa tccctcctgt caatagagtg ttattagtat agccgaaaag 1295521 aatgcaaaga acattcttaa aaaagtgcaa aataaacaaa gtatttgggg gatttgctaa 1295581 ataagaaacc gattgtggct gtattataga aaaaaaccat ctgccaaatg cagatggttt 1295641 tttcaaatta tactagctgt gtctgctgtg ctcttgcctg ttttgcggct tcaaccatat 1295701 ttttcaatgc tgcaaccgtt tcttcctgct gtcttgtttt caatccgcag tctggattta 1295761 cccagaagcg gtcagtcgga cagacggcaa gcgcatcaac gataatattg tacatttctt 1295821 cagttgacgg cacacgaggg ctgtgaatgt catatacacc aaggccaagc cctttcaaat 1295881 acgggtggtt ttttaagtaa tctaaaaatc ctccgtggct tctgctatgt tcgattgtaa 1295941 tcacatcggc atcaagatca ttgattgtat caacgatatc ttcgaagttg ctgtagcaca 1296001 tatgtgtatg aatttgtgtc tcgtttttca cggaagaagt ggttaatctg aaagcttctg 1296061 ccgcccaagt caaatactca tcccaatcgc gggttttcaa tggaaggcct tcacgcagcg 1296121 ctggttcatc gacttgaatg atttgaatgc ctgcgtcttc aagcgcttta acttctttgc 1296181 gaagggcaag cccgatttgg aaggcgattt ctttcctcga gatgtcgttt cgagggaaag 1296241 accagtttaa gattgtaacc gggcccgtca gcattccttt cacatgcttg gaagtcaatg 1296301 actgtgcgta gactgtgtct ttcactgtca tcggttcaat aaattcaaca tctccgtaaa 1296361 tgactggcgg gcggacacag cgtgagccgt atgattgaac ccaggcatat ttagtgaagg 1296421 cgaaaccggc cagcttttca ccgaagtatt cgaccatgtc tgtccgttca aattcgccgt 1296481 gaacaaggac atcaagctcc aattcttcct gaatatcaat ccatcttttt gtttccgcat 1296541 tgataaagtt ttgatactgt tcatcggacc actcagcttt ccgccatttt tggcgtgcgc 1296601 tccgcacttc agcagactgc gggaagctgc cgatcgttgt cgtcggcaaa agcggaaggc 1296661 cgagagattc attttgtagg gctaaacgtt cttcaaacgg aatcgggcgc ttgaagtctt 1296721 tatcagttaa ttgctcaagc tctttctttt gttcagaatt ggcgcctgtt gcaaactgtt 1296781 taagcgcctg gatatcagcc ttagcctgct gaatctcttc gctgatcgcc gcttttcctg 1296841 atactaagcc ttctttcaaa gctgtcagct cggccagctt ttcttttgcg taggataatc 1296901 cgttcaatag gtctttttcc aaatgctcat cagggtgttt cgctactgga acatgcagca 1296961 ggctgctgga aggctgaatc cacagttcat caacttttgc aatgctgaga atatcaagaa 1297021 cggcatcgag acgctcttca aggtccgctt tccaaatgtt gcgtccgtcg ataacgccgg 1297081 ctgccagcac tttatctgtc gggaagccat gtgttttaag ctgttccagg tttctgcctt 1297141 tgtcgtgaac gaaatcaagg ccaattccct gaaccgggta agagatcagc tcttcataag 1297201 catcaacaga atcaaaatac gtctgcaaaa gcacattcaa ggatgaaagc tcacttgtaa 1297261 tgctttcaaa taattctttt gcgccgcgta catcttcact agaggcggta acgagcgccg 1297321 gctcatcgat ttgaacccat tttacgcctt cttcttcaag ctctttcaaa agctgtacat 1297381 ataatggcac aaggcgtttt tggatcgctt ttgcttcaga cggttcatag cctttagcaa 1297441 gcgtaacgaa cgtataaggg ccgacaatca caggctttgt ttccacaccg tattcctgtt 1297501 tgatccggcg ataatcttcg agttgtttgt ttcttgtcag acggaactca atgctctcgt 1297561 catattccgg aacgatgtaa tggtaatttg tattaaacca ttttgtcatt tcactagata 1297621 cagcgtcttt gattccgcgg gcgatagcga agtatgtatc ggtagcgtca gtcaaatgtc 1297681 tgaaccgttt cgggatccag ttgaagctga ctgctgtgtc gagtacatgg tcatactgtg 1297741 tgaaatcaga aacaggcaca acatcaatct gctggtcaat ttgtgttttt actgcggata 1297801 aaaatagttc gtcgatttgc ttcaaaaacg tatctttatc agtactgcct ttccaatacg 1297861 cttcaagtgc ttttttccat tcccggttca gtccgattct cggaaatcct aaattcgatg 1297921 ttttgatggt tgtcattgtt tctcctcctt tatatgtaaa acactctctt tcacccgcgg 1297981 atacaggctg ctaagaggtt ttctcacaac aaaaagcctc tttcccatga gagaaagagg 1298041 cttttctacg taaaacactg cctctctcat ctctcagaca caatctgatg gaattagcac 1298101 cgtgccttat gagacatcag tctcggcgcg aaaagcagtg cgccccattt cacaatggta 1298161 ttacggtcgg ttgctgttgg ggtcaaaagg ccaatccctc gcccaactct cgataagaga 1298221 aaatgttatt aattttttga aaagttgaat catttgttgg taatcttaac agtaattcaa 1298281 attcattgtc aacatagaat ttgaaatttt tatttacatg atgtggtgta tattatataa 1298341 gaaaaataat cttatagggt caacaaatgt gattgctctg ctttttctgc gagctcatca 1298401 ggagctgtta aatacaggaa tccattgcct gccagcgttt ttgcaatatc aagaggaagt 1298461 gtcctgcgga ttagctgtgc gaaaacctca gattcagaaa gctttctttg aaatgattct 1298521 tcttcatagc ttttgattaa agcaagcgca ccgctgacat gaggggcagc cattgaagtg 1298581 ccggtcagct taccgtactt cttgttggga agggtggata agatgttttc tcctggtgcc 1298641 acaaggtcaa tctctttatt cgcgttagaa aattctgata attctcgcgc tacagaaaca 1298701 gatccaactg caatcacttc attataagct gcggggtagg aaagctcttc tgtgcgttcg 1298761 tcgccgtcac cttcatttcc cgctgcacaa acgacaagca ctccgttttt cactgcgttt 1298821 ttcactgctt cttttagctc tggcacatcg cttggccctc caagggacat tgagatgatg 1298881 tcgactttct gttccaccgc gtagttgatg ccgttaatta tccattcgta ttgtccgctg 1298941 ccgttctcgc cgccaagaac cttcacaatc aataggcttg cctcaggcgc gactccggca 1299001 atgcctccgt ttgaatcatt agctgcaatt gttccggcga cgtgtgtgcc gtgtccgttg 1299061 tagtcggaaa tcgcatcttc cttgccgccg tcgtcatccg tgaagttctt tccgccgatg 1299121 atttgatttt ttaaatcagg gtggcttgtg tcgcagcctg tgtctaatac agcaacttta 1299181 atatttttgc cttttacccc ttttgcccac atttctggcg ccttaatcac tttaatgccc 1299241 tcaggaagct cgtttacatc catgatctgc tcattcgtca catacgggat caagcggatt 1299301 tcaccattca taaaaaagcc ctcctttttt atgcttgcaa gtggattcaa gggtgttgcc 1299361 tcatattata tgaaaaaagc aagcgctcgg acagagccat ttgaagcatt ttgaaaaaat 1299421 aggatacaca ccaaagaatt agtaatcttc aaaatattgg atggcttcaa catgtatgac 1299481 tgggattcaa ctgtaagtca agttataata gtgttgggga aaggagcagt gtcatgaaac 1299541 tgaatgaaaa attatatgca tttttttcag agcatgtgga acaaatggcc gaggaatgga 1299601 ttgaaacgat ggaggaaagt gatccgaatt cgctttacgc cctacataat gcaacagtaa 1299661 cggaagaatt gaaagagcag gacagagaat tttaccggca tctgaattac atgtatgttt 1299721 taccggaaaa acaatttctc gaagagtttc aagagtgggt cattgagctg accaacgatc 1299781 aaaaacatct cgacacaccg gttcagtatg tcattcggga gtttatgaga aacaggagat 1299841 tatatacgaa gtattttgag aagttcgcag aagaaaatga atcagcgttt gaaccgggag 1299901 agaagcaaaa atgggcagat ttgattgtaa aagtatttga tttcaccatt tatacattcg 1299961 ttgatcacgc tgaaatgaat gccaagcagc aattaaacgc ccaaagagaa atgatattgg 1300021 aattaagctc acctgtcatt accctgagca aatcaacagc tctgctgccg cttgtcggtg 1300081 acattgatac cgaacgggcg aagtttattc tggaaaacac gcttcaagct tgtgcgaaaa 1300141 gacgtgtgga gcatctgtta atcgatctgt caggtgttgt tgtggtggat acgatggtgg 1300201 cgcaccagat ctttaaattg attgaggcgc ttaatctgat cggtgtccgg tcaaccctgt 1300261 caggaatcag gcctgaaatt gcgcaaactg ctgtacagct ggggattgac ttttcgaata 1300321 ttactattaa aaccaacctt gcccaagcat taaactatca tcaataaaaa aatccgctat 1300381 ctgtgatagc ggatttttta tgatgcgaaa cataaagata cgagaaagga tcccgcgaat 1300441 aataagagga cgaggcaaaa gaacacccag tcgcgccggt tcacgctcaa tgtcctgtag 1300501 tatgtccggt ttctgcttcc tgtaaatcct ttcgattcca tcgcaagcgc tgtccgttcc 1300561 gcttttctga tggcgcttgc caatagcggt atggtatatc gttttaacgc actgatttta 1300621 ttaatgatgc cgctctccgc cgctcctcct ctgattttat gagcctgctg aatcagctgg 1300681 acctcatcct ttaacagcgg aagaaagcga aagcctgcaa tgacaccgta cgcgagcttt 1300741 ggtgagagcc tgcactgctg gacaaggctc agcataaata gaatcggatc ggttgtaaaa 1300801 acaaacatca tcgataaggc ggaaaagcat aaaatacgaa acccgagaga gatgccgaca 1300861 gacacattat cgctgttaat ggagataggg cctgcttgaa acaaaaaatt atccggtgtt 1300921 gtcggcactt ttccaaaaac tgcggctgtc cacacgcatc cgaatgctaa aatcaaaaac 1300981 ggaatcgtaa acaacaacca ttttttcaat gggattccgg ccgccagtaa aacgcccgca 1301041 acgatgatga tataaaaaca tgccggagtg taagggttgt aaataaacga cagcatgacg 1301101 acacaacaaa aaaccgccgc cgctttcaca gtcggattaa tgagatgtaa cggttgcttc 1301161 atcacgcacc tcctcttgaa atgccatcca ttcatataga aggggaaggg tgagctttgc 1301221 tttttgaaca agccctgttt cttgagaaaa caactgcgct ggagatccgt caaaggccag 1301281 gcctgtatcg tgaagcacaa gcacgctgtc agcatacgaa gagactagct ccatatcgtg 1301341 tgtaatcata aggacagcag ttccctctgc cttgatacgt tgaatcattt ccatgcattc 1301401 agccgccgtg cgggcatcct ggccaaaggt tggttcgtct aataataaaa cctttacgtc 1301461 atgcatgagc atagtagcta cgctcagtcg ccgtttttgc ccttggctga tcgcaaacgg 1301521 atgatgatca gccaaatgcg caagaccaaa acgctgcagc aggtgttgcg cttttttctc 1301581 agtttcagca tttgctttct ggccgaacag aagctcgtca tacaccgtat cggtgacgaa 1301641 ttgatgctca gggttttgaa aaacaaatcc catccgttta cgcaattctt tttctttata 1301701 tttctgcagc ggctgatcat agagaaggat tttgccgctt tgcggtttca tgagactggc 1301761 cagaactgat aggagcgtcg attttccagt tccgttcgga ccgacaagcg ccgttaaaga 1301821 gccttcgcgc aacgaaaagc tgatgtcttt gaaaatcgcc tgctgtcctc tcgcgaacga 1301881 aaggctgctg acttcaagca cactctcccc agaaggggct ttcttctttt tgacatgccc 1301941 ggcaggaata ggctctttga acagcatctc ttttgataaa gtaaacggca tactcagctt 1302001 ttcctgcaga tgacagacct ttggaatggc gatgcccaat ttctttagtg tctccgcttc 1302061 atgctgaaat agatttttcg tcaggccatc cagtgccttt ttgcctgatt tgtcgagtac 1302121 gatcgttctc tcaatccaag gcgcccattc atcaagctgg tgctcaatga cgaggaggct 1302181 gaaacctttt tcccgctgaa gatccttcat cagatgaacg aactcccgag ctgagaaagg 1302241 gtctaaaaga gaggtcggct catctaaaat aataagctca ggctccatcg ccaaaataca 1302301 ggcgagagcc actttctgct tttgtcctcc tgaaagggtt gagatcattt tttcttttaa 1302361 atgggtaatg cgtaattttt ctaatacggc gttgattttc tctgtcattt cttcttttgg 1302421 aatttgcaga ttttccagcc cgaacgctat ttcgtcctcc accgtcagca tgcagaactg 1302481 ctgatcagga tcctgaaaaa cgaccccggc atgctgagta atcgtttcgg aggtttcagc 1302541 atctgtgacc ggcttttgaa atagaaatac atgtccggac tgaatgccgt cgcaagcctc 1302601 cggatataga ccgtttaaac aaagggcgag cgagctttta ccgcatccgc tcggtcctaa 1302661 taataaaaca cattctcctt tttgaagctc aaacgaaatg tcttgaaaaa ccggtttctc 1302721 gtcttcttca taagagaagc tgagctgctc aaccgtcaga agctcatcaa aggcttgcat 1302781 gttctgacgc ccgcttccgt ttctttttca gttcctttcc gagtgccatt ccgtttaaca 1302841 cacctgtata agcgagagag tcgctgacag cttttccgag aagccccgcc aaaagcgcgc 1302901 cggaaatgag gcggatcaca agcataatga gcagataacc tggtgaatag gctgcatagc 1302961 cagaaacaaa gagatcatag ataaagctgg ctactgaaga ccccataccg gccagcataa 1303021 ggacagggag agagtatgct ttccagcgtg ttgcaagaaa tacagcctca gccccgagcc 1303081 cttgaacaat gccaatgacg atgaccatcg ggccagacgg atttcccagc aggcactcaa 1303141 cgagagcggc aatgatttca gaaacgagcg ccgcacccgg ttttcgaatc atgtacgcgg 1303201 cgatcacaga aacgataaac caaatgccgt aaattggttc ataggcgatt ggcccaaaca 1303261 tacctgcaag tacgtttccg aaatgtgtaa ataataaata aacaacggca aatacgatac 1303321 tgataacgga catgatgaca atttctttta ctttccagct tttcatgtta tccctgcttt 1303381 ctgttttttc ttgatggact gttagccgaa agattcacag tcatggtgat gtggtttgtt 1303441 tgctgctcag ccatgcggaa aacggcctcc aatgtgctga atacgtcatg cgcatccccg 1303501 tcaagctcgc tcgcgtaatg gacaccctgt acgaaagtgc cttgggcttt tgcaatgtcg 1303561 acagcctcca taatcaatcc catataatcc ggctcattca ttggataaag ggcaaattgg 1303621 cacggcgctt ccgccttcaa gcctcggaca gcatcttcat tgacacgctt atcacctttg 1303681 gaaagatatg tatccccctg tgtgtcaccc gggcatccaa tggaaaacgt gccgttcatg 1303741 acgatgtgtt gttcgctgtt tgctgcatga aggtaaatgg cttttgcagc atcgaataca 1303801 tgatcaatcg atccgcgtaa caccgtgctg atatggtcgg ttttcgtcca aaccttggat 1303861 gtatctgttt ttttcagcgc agacttgatc acactgataa aatcatccgt catcggatat 1303921 aaagagaagc gaaaaccggc gattctgctt gtaccgcaaa tatgctccat ttctccgacc 1303981 tcctgttttt ttggtaaaat aaaaaactgc atatcctaag ggaatatgca gtcatagatc 1304041 gattaagcgc acaaaaaaat acaccattcg gtcaacctgc acttccccac gctggtatta 1304101 tccagatcgg gtcataaggg atcaaagcgc gtttcttccg cgctttatct cagccaaaac 1304161 agcaccccta gtgctttccg tatacaattt tttattttga catcataata gatgataaga 1304221 atcattttgt aaacaacgaa atcatttttt tcatataggg acgggagagg atggtcaaat 1304281 ttggaaaaag gacacatatt aattgtggaa gatgaagaaa aaatcgccag ggttcttcag 1304341 cttgaattgg aatatgaagg atacagcgtc acgatcaaac acaatggcac agaaggtctt 1304401 gatgcggcag cggaaggcgg gtattccttg gtgcttcttg atgtcatgct tccggggctt 1304461 agcggactgg aagtgctgcg ccgcttgaga aaaacggatt cgcagacacc ggtcatatta 1304521 ttaacggcgc gagacagtat tcctgataag gtaacaggtc tggacatcgg tgcaaatgac 1304581 tatgtcacca agccgtttga aatcgaggaa ttgcttgcga gaatcagggc ggcgctgcgg 1304641 caaaatggaa caaaaactga agatatcggc acctttctta catatgacga tttgcgggtg 1304701 aacgaaaaaa cccgtgaagt gagacgcgga gacaaagagg tggaattaac gccgcgggaa 1304761 tttgatctgc tcgtctatat gctaaagcat ccgcagcaag tgctgacacg ggagcaaatt 1304821 ctaagctcag tatggggatt tgattatatc ggtgatacaa atgtcgtgga cgtctacata 1304881 agatacatca gaaaaaaact ggactatcct tacgaaaaac agctgatcca tacgattcgc 1304941 ggggtcggct atgccattaa ggggtaaacg atgaagctga agaccaagat tcatctatac 1305001 acttcgatat cactgttgat tttattaatt ttggttcata ccgcagtata tctcattttt 1305061 tcgtctgcgc tgacatcaaa ggatgcggcc cggcttgctg atgagacgga taacattgcc 1305121 gaagcgctgc gtgccgctga aacagaagga gtggctttgc aggatatgct gcaggcctat 1305181 cttccggcaa atggcatggt gcgtgtagtg aatggtgatc aaaaagccgt tatgacgatc 1305241 acaaaagaaa aagcctataa agattttcct ctctcttttc atagcggcga aacggcagat 1305301 gtgaggaaac ctgacggcaa gctgtttgcc gaggctgctg ttccggtgat ttggaccgat 1305361 ggacaagtcg tgtctcttca gctggttgaa agactggaga acacagaaga gagtctgttt 1305421 ctgctgaaaa tcatcttaat cgctgcaagt gctgctgtct gcattgcttc tttttttgca 1305481 ggcagcttgc tagcccgccg aatcatcaat ccgatcagac gattaatgat cacaatgaaa 1305541 gacatacagc gagacaaaga atttaaaacg atttctttag aaggacagtc caacgatgaa 1305601 ttgtatcaaa tggggctgac atttaatgaa atggcaatga tgctgaagga gcactatgat 1305661 aaacagcagc aatttgttca agatgcttca cacgaattga aaaccccgct cactattata 1305721 gaaagctaca gcagcctgat gaagcggtgg ggtgcaaaaa agccggaggt gcttgaggag 1305781 tcgatagaag ccattcactc agaagcggtg catatgaaaa aactgaccaa tcagcttttg 1305841 gcgctggcca aaagccatca aggactcgag gttgatctga aaacaatcga tctgattaaa 1305901 gcggcgcgcg cggttatgca aacgctccag tccgtttatc agcgtgacat attgcttgaa 1305961 acagataaag agagcctgct tgtaaaggca gatgaagaac gcatcaagca gctgttgacc 1306021 attttgcttg ataatgcaat aaagtatagt gaaaagccta ttgagatgtc agccggaacg 1306081 aggaatggac ggccatttct atcagtgagg gatgaaggca tcggaatacc tgaggagcat 1306141 atcccgcatt tgttcgaacg gttctaccgg gcagatgagg cacgaaacag aaaaacaggc 1306201 ggaacaggtt taggcctttc cattgccaag caaatcgctg atgagcatgg cattgagctg 1306261 tctgtcaaaa gcaagccggg acaaggaaca gctgtcacca tgcaattcag cgaacagaat 1306321 gggggaggcc gatgactaaa acaataaaaa cagtatcttt tgctgcagca gccattttag 1306381 ttgtcatcat ctgtacgttt ctcatcattc ggcaaaccca tgagaacgta ttgtcaaagg 1306441 agactgtcgt aaaaaaagtc gaagcctctt atgaaggcaa ggtcacgaaa gcaacacaat 1306501 caaaggataa aaaaacatat gatataaccc ttgaaaatcc aaagggaact tactttgtaa 1306561 aagcagacgc aatatcggct gacattcttt caatgaatag agtaaaagca gtgaatccat 1306621 ctgccatgac agaaaaagaa gccgagcatc tcgcgcttga gcgggtgccg ggaacggtca 1306681 aaaaacaaac acggcaaagt caagttgcca cttataccat acaaaaagaa gacgggaaaa 1306741 catacgaagt gaaggtagac atgcaggcaa aaacagtctt gtctgccgat caaatcagca 1306801 gcaaagatca acaaaaaacg ccgattacga aaaaagaagc caaaacaatt gcagagcgaa 1306861 aaacgggcgg aacagcggat gacgcagatc tcgaagaaag tgagggcact ctcatctttg 1306921 aagtagacgt tgatcttcct gataataagg aagcgacagt gaaaatcaat gcctacacag 1306981 gaaaggtagc taacattgtg tatgaagact gacggtttct catcaaattc tcatcttgct 1307041 ctcgttttcc tttcatgttg agtatgtaaa ctgtactcat acaaaacaaa ggagggctca 1307101 caaatgctca agaaaaaatg gatggtcggt cttttagcag ggtgcctagc ggccggagga 1307161 ttcagctaca acgcgtttgc cacagaaaac aatgaaaaca gacaggcttc ttctaagacg 1307221 gatgcactca ctgaacaaga agcagaagca attgctaaaa cagttgttga cggcacagta 1307281 gaagacattg acagagacct ttacaacggc aaagaagtct atgaagtgga gattgaaaaa 1307341 gaaggtgaag actacgacgt ttatgtagat attcatacaa aacaagcgct taatgacccg 1307401 ttaaaggaga aagcagaaca agtcgccata accaaagaag aagctgaaga aattgcttta 1307461 aagcaaacag gtggaaccgt aacagaaagt aagcttgacg aagatgacgg tgcttacatc 1307521 tatgaaatgg aaatccaaac gaagcaagga actgagacag aatttgaaat ttccgcaaaa 1307581 gatggacgca ttatcaaaca ggagatagat gactaatcaa aacccccgct gcagcggggg 1307641 tttttcatga taagaaacct tcttttggac aatctaagta gaaaaggagg cgaaacgcat 1307701 ggaaaagaaa gaggagcaat acatcaatca ggctgaatat gtccctcatc cgacgaagga 1307761 aggagagtat gccttatttc ttcatgaaac gtatcatttg ctttctgaag atgacgagac 1307821 acaaacaaca gaataagggc ttaggccctt gttttgttcc gtaattgtga tgtaagcgca 1307881 tttattactt ttttgagttg acatagcttg tttttttctg taatctcagt gtgtcaattc 1307941 aattaggaac ttcgttaggt gaggctcctg tatggagata cgctgctgcc caaaaatgtc 1308001 caaagacgcc aatgggtcaa cagaaatcat cgacataagg tgatttttaa tgcagctgga 1308061 tgcttgtcct atgccataca gtgctaaagc tctacgattg aaggcgcccg cacgcttttt 1308121 ttgccgtgct tctttcacct tcaatcccga aggctttttt tatgccttta aaacgaaacc 1308181 aatcaaagga ggtgcggagt atggattctc cccattcgag tcaatctgaa gaagtaccca 1308241 tatactatga cagcaagaca attgattaca cgatgaggag acgaactgcc gcaccttctg 1308301 gcgaggccgg cacgtctccg tagaggaggt acgagtcccg atggttcaaa acatgaccta 1308361 tgacgaactc attttacgca tcattatttt actgcgagac gggaaaatca gggattttag 1308421 aagtgttatt gatgagcttc agccctatga catggcattt atttttaaag aaatgccgga 1308481 aaaacatcgc gcccgctatt tatcttattt aactgtagac gatatcactg atatgatcgg 1308541 ggagctggaa cgcgaatttc agcttgtcgt cttaaataaa gtcggaaaaa caaaagcaac 1308601 actggcgatg aacaaaatgg acaacgatga cctcgctcaa ttgcttgaag aaatggacga 1308661 agaactgaag gaacagcttt tatccagcat ggaagcgtca gaatcaaaag ctgtacagct 1308721 cttgatgaat tacccggctg attcagcggg acgcatgatg acaaaccggt atgtgtggat 1308781 ccctcagcat tacacggtaa aagacgcggt cgtcaaactg aaaagcttcg ctgaaatagc 1308841 tgaatcgatc aactacttat atgttattaa tgaaagcaaa cagctggttg gggttctttc 1308901 ctaccgcgat ttgattctgg gtgaacctga agaaaaggtg caggatttaa tgtttacccg 1308961 cgtcatatca gcagatgctc ttcaggacca ggaagaagtt gcccgcctga tagaacgtta 1309021 cgattttttg gcaataccgg ttgtagaaga aaacaacgtg cttgtcggca ttgtgacggt 1309081 tgatgatatt atcgacgttg ttattcggga agctgatgag gattacgaaa aatttgccgc 1309141 ttccggtaaa gacatcacct ttgacacaaa agcttacgtg gcggcatacc ggcgtctgcc 1309201 atggctgatt ttactcttat ttatcggact gatttcagga agcattatca gctattttga 1309261 agacgcgctg aagcaggttg tcgcgcttgc gtttttcatg ccgatggtgt cagggatgac 1309321 aggaaatacg ggaacacaat ctcttgcggt tgtcatcaga ggtttgtcta aagaagaaat 1309381 gaacaaaaaa acgattgtgc gcctgatctt ccgggagttc agaacaagca tttttatcgg 1309441 agcggtttgt tctgtgctga ttgcgattgt ttctatcata tggcagggga atgcgctttt 1309501 gggatttgtt gtcgcctctt cactgttctt aaccttaatc atcggcacga tgtcaggaac 1309561 gattatccct attattttgc acaaactgaa agtagacccg gcgattgctt ctggaccgct 1309621 gattacaacg ttaaacgata ttttatcttt attaatctac tttggcattg ccactgcatt 1309681 cattcactca ttataaacgt aaaaagtccg tctcaactgc gagccggact tttattattt 1309741 aacggttttt gtaccgaaag tgagcattaa gctgcccctc cagcattttt ttccgcactt 1309801 gcggatcgtt ttttaacatc tgttcttttt tgcgcatatc ctttaaaatc tctgccgtct 1309861 gtacgccgtc ttcacgctta ttggcgatat ccatcagccg ctccacatcg gcaaaggagt 1309921 attttcttgt cccccttgaa gaacgctgcg ggtaaatgag ctttcgttcc tcataatacc 1309981 tgatctgtct tacggacaat cctgtcaatt cactcacaat tccgattgaa atcacttttt 1310041 tgtctttata agaatgatct tctgtggtca tttttccacc cctggatgtc ttttgataat 1310101 agtatataaa aaacaaagag aaaaaacctg acgcttgtca tattttctaa catcaaatag 1310161 aagatttttg aaaaaatacg gaagaaaaat taacaagaat aatgcgtaac acccaagcgc 1310221 gttttatcct ttatgtaacg aatcaaacga ggaggaagga taatcatgga ggaagaaaaa 1310281 gcagtctcac tggcaaaaga aattatagag ttggatatca agcgtgatga aatgctggag 1310341 acgtttatgc agcttgccgg agaacaggct tttcaattat taagatcggt tcaaaacgga 1310401 caataccgaa aatcttcgta aacataaatt ctttacatta gattcatacc acgttcattt 1310461 aaaaagagta tcttttgtat aggatacctc aaaatgaagg aggacgctat gagtaattta 1310521 ttgaaatccg ctttagaaaa agaacgacgc cattattctg aaaaactcta tcagataggg 1310581 gtttataata aagaggtcat gaacaaaatg acgatttctg agcttcggaa agaatacgct 1310641 tatttctttc gaagcattac aaatcataaa aattatcctt atacaagata atgtataagg 1310701 atttttttgc ttttagaagg aatttctcga attatagcga atacgtatag taagggactg 1310761 aactcttatt atatgtaagg gttttcatta tttttttata aaaatcctat atacgaggta 1310821 gatatgatga gattatcgtt taacgaagaa gaagttgagc gtgcgatgaa tttgtacaga 1310881 gtttttgcaa gggctttcaa aagtgtgtcc gaacatagta tccgtgatag caaagagcac 1310941 ggttttaatc ccactgaatt tgctgtactg gaactcctgt acacaagagg cccgcaaaaa 1311001 ttacagcaaa ttgggtcgag acttctgctt gtaagcggaa acgtcacata tgttattgac 1311061 aaactagaaa gaaacgggtt tttagtaagg gagcaggacc cgaaagataa acgctctgtt 1311121 tacgcacatt taactgacaa gggaaatgag tatttggata aaatttatcc gattcatgca 1311181 ctgcgtattg cgagagcgtt ttcaggtctt tcgcctgatg aacaggacca gctgatcgtc 1311241 ctgctcaaga aagcaggcat acacagccag catttgctgt ttcgttaact attctacact 1311301 ctctatttca ggagagtgtt tttttgtttc catatgattc tttttaaaac atctttaatc 1311361 ttcctatcag acatttcgcc aaggtatcca ttgacgtgtt ttttatactc cttcatctgt 1311421 tcgttcgatt gaaaaaatgc cgcgatatac tcttctgctt tctgcatgtc ccagtttctc 1311481 atatctgtga cgagtttcct ttcatgtaga aggtttaaat tcatttcctc ctgtcccggc 1311541 agtgcatgat aaataaatac cggaagccgt ttctgtaagc attcactgat ggtcacgcct 1311601 ccgggtttag tcatgatgcc tgtcgcctgt tcgtacaaac ggttcatctc tgctttgctg 1311661 tgaaggtaag gaatcgcctc aatcaagggg tggtgtaaac ttttgacata ggagtagagc 1311721 ttttcgtttc tgccgcataa tattttgtat aagatctttc cgcctggcga cagttcctgc 1311781 acccatttta aaatcccacc gacccccata ctgccccctg tgatgatgat ggtatatggc 1311841 gggtggtgct gcaaggtatc tgctgattcc atttcaaaat tttggtgaac tggaatgccg 1311901 gtcaagtata tgttgttctg atcgataccc tctgatatta gctgcttctt tacttccgtg 1311961 ctcggaacaa aatggtaatc aatgttcttc cgtccccata attgattcac gaaaaaatca 1312021 gtgtatacat tcacaaccgt cagattcgga tattcaggct ttagtcggtt cagcagataa 1312081 gaaggcagcg catgtgtgca gaaggcgata tcaggctgtt tttcttggag gatgtgcctc 1312141 atttgctgtg tgaacagcca ttcgtacatg aaatagcgtt tgtcatgctg aaattctccg 1312201 caggcgagga gcctgtaaat gccgctgtac gttttcggga aatattgaat ccattttaaa 1312261 taagccacgg aggacaattt ttctaaccgc ctatacgaat gtgaaaagat atcaatcttt 1312321 tcagctgcca gcccttgaga ctctaattca gcctgcaatg catcagccac atgatgatgg 1312381 ccggtggaaa tgcttaaaaa aggaaaaatg agaatgtttt tcatgacagt cctcctaaaa 1312441 aaatatggca actatatttt gaggagaacg ttcacaaaat ataagggtgt ttttgatcat 1312501 aaggaaggtg aaaagatgaa aacttgtttc ctttccatat ggagagtggt tgatccgatt 1312561 tatttctttt tttcaaggct aagcttgatt gacaacgatc aaaaaagcgt ttttcgagtc 1312621 aggctgacga agtacaaagg acatcatgtc gtgcttagcg acggaacgca tataagaaaa 1312681 aatgatgtgc tcgttaaaat ccacctgcat aacataaagc tgatcaggga gctgcaaagc 1312741 attgagagcg cagtcagaaa gggaatcatt atttatcaga aagtatatca atcgatgccg 1312801 cttcttcttg actatatcaa caatcataaa aaaagcgaga aaatcaaagg aatcattggg 1312861 attacaatgc ttgacaaagg tgtggaaagg ctcggctttg atgtgatcac cccggtgaac 1312921 cctttttaca gatgctttaa aaaagtgtct catgtgccga ttttatattt gacttcaaag 1312981 cctgtgagct tgcggcattt accgaattca tcctatttgt ttatctcaaa agaaaagctg 1313041 cagaaaacct atcaaaaaaa agactgatgc ctcggtcagc acagtctttt ttgattaaat 1313101 ctgatgaaat gtcacttcag ggcggcttcc gacacggata tttacgccgg tttgtcccaa 1313161 gccctcgctg atataaaatg gtttatcgtg atgataatga aggcctttaa tcatgttcat 1313221 tcgcacgagc tttcccattt tcaccaaatg atacggtttt ggccagtgaa tttgcccgcc 1313281 gtgaaaatgc cctgacagca ggtaatcata atgaacatct ttcatatcca gaataatatt 1313341 tgggtcatgt gttaagacaa gatgatagcc attttccaga ctttgataag agccggtgat 1313401 attactccga ttcgtactgt aatcatcaat gccgataata ttgactggtc ctgcagccgt 1313461 ctcgattcga acatgttcat tttgcagcgt gatacagccg ttttcctcta aaactcgctt 1313521 caatctctga aagtcctctt ctttcaatac ataatcgtgg ttaccgaaca ccgcgtacat 1313581 tccatatgca ggctttagct tttgcaaggc gttcaagtaa cctgccagtt tcggaatatt 1313641 acgtttccga tcaagaaaat ccccggtaag agcaatgatg tccacaggct gatcttttgt 1313701 taaatgatac agctcctcag gtgagactga aatgttttcc aagtgaagat cagataaatg 1313761 aaggatattt aatttttttc tggctggaag gccgtctttt tggtcgattg aaatggtgtt 1313821 gactttcaca tcttttgtat tgcggttcgc tttatataga aatggcacaa atacgagtat 1313881 ggccaatgaa agtaagattg taaacaaaat atatcccctc ccttctatca gtatagtaag 1313941 tgatcaagcc ctatggatag cgggaattaa tgggtagaga caggttgaaa aacggattgt 1314001 catatgatga atgatttgga agggaaaagg gataataaat tttgacacat gaggcagaac 1314061 atgccgacgg agtcagaata acaaatggat gtgtaagcaa tgttacgatt gatgagacaa 1314121 caaaaaaaag aaacatatta tctctggatc gcattatttc ttcttttatt gtatgtatcc 1314181 ccgcttttta ttttaaagga agatgcccat atccgggtcc acgataattt agattccaac 1314241 atcgcttggt acaaggttct ggccgatagc ggagaaatcg tcggcaaggt tgacgctgcc 1314301 attccgcaaa tcattaacgg gctgccccgg gatgcctttg gcaccgagtg gagcggaatt 1314361 gtttggctcc atgctttctt ttcttccatg accgcctatg caataagcca gacggttaca 1314421 agagttgtcg ctttttttgg aatgtatgtg ctgctgaaga aacatataat cccggaacca 1314481 aaagcggctt tcatccgaat tggcgtatcg cttgcatttg ccttaacacc gttctggcct 1314541 tcgggaatgc tgagtacgct tgggtaccct ttggcactgt gggctttttt aaatatccga 1314601 aaaggggata tctcatggag agagtggctg acgctgggct tgctccctct atactcaagc 1314661 tttgttctag gcttcttctt tttcctggca gggatggcgt gtttttggct gtatgatgcc 1314721 attacaaaaa gaagatggaa tttgatgttc ttaggcagta ttgcatttat gacgagtatc 1314781 tatcttttcg ttgaatatcg gcttgtctat tcgatgctgt ttgagcacgc accgatgcat 1314841 cgtatcgaat ttatctcatc taggcatgac gtttggcatt ctcttcgact atccataaaa 1314901 aactttgtct atggccataa tcatgtgatg accgttcata ccgttgtcat ccttccgatc 1314961 ctgatggtcg tatttgctgc tctgctgttc aaacgaaatc ggacaaagcc agaaaatgtt 1315021 tatctgtttt tatgtgtgct taattacggg ttgtcattat ggtatgcgtt ttggttcaac 1315081 aaaatttggg ctgttccaaa gcagaaattt gcttttttag cagaatttaa ttttgcccgt 1315141 tttcattttc ttcggccgct tgttatatac gtgagctttg cgcttgcttt atatctcatt 1315201 tggcggatgg ggaaaggatg gaaatggctt gtgtacgccg cagtcgctgc acagctgatg 1315261 gtgttggcgc cttttaatga agaatatacg tatggtgttc attacaacgc gccgacattc 1315321 agggagtttt atgcatcaga gcaattcaaa gagattaagg aatatatcgg acgtccgcaa 1315381 gattcgtata gggtggcgag catcggactg catccgtcta tcgcccaata taacgggttt 1315441 tatacgttag atacgtataa caatctgtat ccgctctcat ataaatatga atttagaaaa 1315501 atcatcgaaa aagagctgga aaaaaattct cggctgaaac aatactttga tgaatggggc 1315561 agccgctgct acctttttgt cgatgaactc ggtaaacgat atgatttcaa aaagaactcg 1315621 aagaaaacga tcaacaacct tcaattaaat acagatgtat ttaaaaaaat gggtggacgg 1315681 tacatttttt cttcagttcc gatcatgaat gctgaacaaa accatctcgc gctcgtaaag 1315741 acgtttgacc ataaagattc cgcctggcgc atttatttat atgaaacaag ataaggagga 1315801 tatcgattga aacagtcaca gccagtatta accatcgtcg tcccgtgttt caatgaagag 1315861 gaagtgtttc aagaaacaag ccatcagctg acagaggttg tagatgattt aattgaagaa 1315921 aaattaattg ctgaagacag taaaattctg tttgtcgatg atggcagcaa agaccgcact 1315981 tgggctttga ttgctatgga gagcataaga aacaagaagg ttaccggctt aaaattagcc 1316041 tgcaatgtcg gccaccaaaa agcgctttta gccggattgc ataaagcgaa gaataggtca 1316101 gactgcgtca tttcgatcga tgctgatctt caggacgaca tctctgtgat ccgggatttt 1316161 atgctgaaat atcatgaggg ctgcgagatc gtttacggtg tacgccggag cagaaaaacc 1316221 gatacctttt tcaagcgcac gaccgcgtta gggttttatc gtctcatgaa taaacttggg 1316281 attaaattaa tttataatca tgctgatttt cgtttaatga ataaaaggtc ccttgaagag 1316341 cttgagcgtt atccggaagc gaatctgttt ttaagaggta ttgtccccat gatcggcttt 1316401 aaatcggccg aagttttgta tgaccgcaag gaacgctttg ccggcaaaac gaaatatccg 1316461 ctgaaaaaga tgctatcctt cgcttttaac gggattactt cattcagtgt cgcaccaatt 1316521 cgattcttta cgcttttagg gtttgttttg tttttcctca gcgctgtggc agggattggc 1316581 gcgtttattc aaaagctgct cggccatacg aatgcaggct gggcgtctct tatcatatcc 1316641 atttggtttt tgggcgggct gcaattgatg ggaattggaa tcatcggaga gtatattgga 1316701 acgatttttt ctgaagtgaa aagacggccg aaatacgcga ttgatattga tttgtataat 1316761 gaacagctga gcccgcttca gcgccaggaa aaagagcggt tagaaaaaaa gtacagttaa 1316821 acacggaaag agctgacttc attagtcagc tctttttctt caactgatgc aatatagcgc 1316881 taagcggttc gtcttgcggg ttgcggtaaa aatcaaaaaa tgggcagccc tgcttcttaa 1316941 ttcgatcgat gaccgtatca attgtaaaca gagcgggtgt taaagatgat tgcacctcat 1317001 gccagtagag cggggctgca acagtcccaa gctcatttcc tctcgttgaa tagggacaga 1317061 taatcgtttt tccttctgca tgctgcaaat aatcaagata caatttgcag tgtctgtttt 1317121 taatcaagcg ttcagtggta aagagctcgg gaaatgcatt ggtgcagtac tctgcgatca 1317181 gctgcgtaaa ttggcgtgtt tcttcatacg taaatgcctc gggagacaag ggaatataaa 1317241 gctggatgcc tttgttgccg gacagcttcg ggtacgatgt gatgccaaag gaatccaaca 1317301 gccgcttcag ttcatttgcg gcctgcacgg ccataagaaa gtcatctcgc gaaggcgggt 1317361 ctaaatcaat gacaatctca gccggacgcc tgcttttaat ggtttgaaaa ggaacgtgaa 1317421 actccaaagc aagctggttg caaagccata gcaatgtaga catatcctca cagacaatat 1317481 gttcatggct tccatcatag aaagactgaa caaaatccgg cgcatagtcc ggcttgtttt 1317541 tttggaaaaa tgattcgctc ctagatccat gcggatagcg gatgacggtg acagcccggt 1317601 ttttcagaaa tgggagcagg tagtcactga cttcaatcat atactgaata aaatcttctt 1317661 ttgttttttt attcttttca aatatgattt tatccaggct tgtgaactgg agctttgggt 1317721 gaaccggttt ggagtgtcgt atgacttgcg catacgtgca ttcggtccag tccatttgga 1317781 attcgaaacc gataaacgat acctctctta atgtgccttg gagaattgtt aagtattgaa 1317841 cagctgcaca aatcgaaggt tcaagcgtaa attcgcctga gggtgtttga tgtccgtgct 1317901 gttccataat ctcgcgtata gcgctttttt cctcatcacg cattccgtgc gagacagagg 1317961 caatcggtgt cattattccg ttttttaaca ccgataccgt cagaaacccg ttgttagggt 1318021 tgaaccctgt tatgcaaaca taagcttgtt taaagttttt atatttgagc caatcggacg 1318081 accgcttctt ttcaagccat ttgctgtttg ttttcttcgc tacaattcct tctccgtcat 1318141 attttattac catctcccag agttgatcaa aatgatcata acagggaatg gattgaatgg 1318201 tttcttttgc gtaaggatct ggagatgcag gaagctttgc tgcggatatg agttcacgca 1318261 gcgatttttt gcggtccaaa tacgaaagaa gcgttacatc ttctccgctt cgctctaaca 1318321 aatcaaaggc gagaaagcag cacggccgcg cgtttgccga ttcctgaatc ttgtctggcc 1318381 ttttcaaacg cccccgcact tgaaggtgtt caaaatctgc acgacaggga ttcaccaaac 1318441 atacgatttc accgtcaagt gtcagcggaa gctctttttc taggtgctga aaggcagttt 1318501 tggcgaattg tgtgatttca gggaaggtgc tgctgagctc cacaccattt ctgctggtta 1318561 aggtcacacc tgaagaatgg atgcggagaa tacagcggta cccatcatat tttacttcgt 1318621 aacgccattc tgctccgatt ggcggtgacg aagttaagac cggctgcatg gtaaacgcca 1318681 tgcgctatga tgtgccggag gctttttttc tagttgtttt ttgtttttta tctccggctc 1318741 ctttcggttc agcggcttgt gcaggtgcgg cagccggtgt ctcccggttc ggccttctgg 1318801 ttctgtcgat gctggcttgc agagcgctta ccaggtcaat gacatcttca cgaggtggcg 1318861 ctttatcagg agtgacagcc gtttctttat tttctagctt gtcgttgact ctttgcagca 1318921 gcgcctgtcg gtacgtgtct tcatatttct caggctcaaa cttagcagtc agttcatcta 1318981 ttaatgtgat agcagtttgc agttccttat cgtttacatt cgattgatca ggtacacctg 1319041 ggacttgagc ggcgcttctg acctcatcgg gataatggat agactccatg acgatacaat 1319101 tttcataaac gcggagaatc gccagctgct gctttgacct gattgtcata ttggcgatac 1319161 cgatctttcc ggttgagcgc agcgcctcac gcagcagggt ataggccttc gtcccattat 1319221 ccccggggcc gacaaagtag gagcggttaa aataaatcgg atcaatttcc tgaagctgaa 1319281 caaagtcaac aatctcaact gctttctcct catgctcctg ttttaagctt tttaaatctt 1319341 cgtctgtcag cactacatat tttcctttta catattcata tcccttcaca atttcatcag 1319401 gactaagagt tttttcgcaa tttgtgcaaa ctttctcgta tttgattggt gcgtgatcct 1319461 ctttatggag gctgcgcagt ttaatatctt tatcttctgt ggccgcatat agcttgatgg 1319521 ggatgtttac taatccgaag ctgatcgatc ccttccacat tgtatgcata tcgataaacc 1319581 cctttttttc tttagtgtga agagaaggag tacgattcat gtgtagtaac ttatgggtga 1319641 aaaaaagccg gcgctgttat tgcgacggct gttcaataat gaattgttcg aattgttccg 1319701 gaggtattgg cctgctgaaa aagaagccct gcaaatggtc gcagcctttt tcaaaaagaa 1319761 gctgcttttg agctgcattt tccacacctt cggcaatcac ctgcaaagac agctgatgcc 1319821 ccatggcaat aatagctccg gtaatttgct ctgatttagg atgggtctga atatcgtcaa 1319881 taaatgattt gtcaatcttc agcctgtgaa tcgggaagtc cttcaaatag ctaagagagc 1319941 tgtgaccagt accgaaatcg tcaatactga ttctgattcc taattctgtt agggatgaca 1320001 aaaccttttt ggagtgattg agattgtcca ttgtcatgct ttccgtcacc tccacttcaa 1320061 gaagctgcgg aggaagctgg tacttattaa gcgtatcctt gatgagggga atcagatctt 1320121 tagattgaaa ctgtctggcg gaaatattaa tggcgacaga aagatcatag cctttgtcat 1320181 gccaaatcct tgcctgcttg catgcttcat ctataatcca ctttccgata tcaataataa 1320241 gtcccgtttc ttctgcaaca ccgatgaatt ctccgggcgg acgcagttgc ccgtctggtg 1320301 tcacaaggcg tatcagtgct tctgctcctg tcattttttg ttttttcaca ctgaattgcg 1320361 gctgataatg caagacaaat ctatcgtttt cgattgcttc tctgagtacc atctcttggt 1320421 taagcttaac ggtttctttg ttgccgattg aaaaagaata gtatctgtat ttgcttttgt 1320481 ttcgttcttt agccgcatac atcgccatat cagccttttt catcaattca aggccatccg 1320541 tcccgtcttt tggagatatc gcaatcccga tactgacaga tgtgacaagg gtgtgatctt 1320601 gaattttgaa aggttttttg aatttttgga taatttttct tgctaaaaca tctgcttcgc 1320661 ctgttcctgt attggcgtct gttaatataa taataaattc atcaccgcca agacgggcga 1320721 taaatccgtt atcagggact acagatgaca ggcgtttagc tgcaaactga agcaattgat 1320781 caccgacatt atgccctaat gcatcgttaa tcactttaaa ccggtttaag tcaagaaaga 1320841 atacaacagt gttataatgc aaggaatgct cgcgattcag cacctttgtt agatgagaga 1320901 tggcatgcct tctgttaggt aagtctgtaa gcgaatcata atgagccatt ctatggattt 1320961 ctttttctgc tttgtactgc ttcgtcatgt ctttacaaat gacataaatg ctgtctagtt 1321021 cctgattgac ctcaacaggt ataagcgtaa tatttaagtg aaactggcct ttttcagtga 1321081 taagatcgct atcgctgttc atcgcttgtt tatctttttt aacttgctca aaaaggcgct 1321141 taaccttcag tgatgtgtaa ttcctccagt catgcatgct gaagccaaat ttgctgatca 1321201 tttcctcacc agcgtgattg gaagatatta tgtctccttc taatgataaa ataaaaattg 1321261 catcaatatt gtggacgatt aaagactgaa atcgctgttc gttatccttt atgcgttcgc 1321321 tctgtttaat aaactttcga tctgcatggg aactgaataa caataacgtt tggatacaaa 1321381 aaataattaa agtaacaaaa attgaccaat gaaacgtttg cacctccata tggcttccgg 1321441 gcggagccat gtccttatgg aaagttgccg caagcatccc tgtgtagtgc atgcccgaaa 1321501 tcccaatgcc cattacaatt gaactgacgc ctttatagaa tataagatgc tcagaatgtt 1321561 tttttacggc caagtcaaag aatattttta acgagacgaa agaggctgca atcgcaatga 1321621 taattgaaac tgtaaataaa ataggttcgt aaataatcat tacccgggaa atggcagaca 1321681 ttccgatata gtgcatagaa gcaatagatg cgccaagcac aactgatccg gtaagcagtc 1321741 tgtaatatgt aagaatgtgc cggctgacaa aatataatga cacaaatgat cccgaaacag 1321801 atgcgccaat ggctgccatt aaaggcatga attcatattc catcggcatt tccatatgga 1321861 cggccatcat ccctacaaaa tgcattgacc aaataccgaa tcccataata agtgagccgc 1321921 cgatcagcca aattttactt tttaagcctg tattgatggt gactttcctt gaaagttcaa 1321981 gggaaatata cgaggcggta caggcaatta gaatagataa acatatgaga gtcgtattat 1322041 atgtaacgtg tatttccaaa tggagattcc ccccgtatcg tgtgttccag tcttgttgac 1322101 tctctttatt atcggctgct taaccgcaga gtttcagcct tcaaaacgat agaaatacga 1322161 gggagatcta tttttagttc aactgaccgt gaaaaatgtg ttaaaatcat cttgatgttt 1322221 tccgaaaaga gaaaaatgta tgatacataa acatgaaaca agggagttgg tggctatcga 1322281 agagctggtt atgtcatgga ttgaagcatt taaaagctta tcttattttg gaatatttct 1322341 agcgctcagc attgagttta ttccggccga agtcgtcttg ccgcttgcgg gctattgggt 1322401 atctaaaggc gatatgacac ttgctggcgt tgttttggca ggatcgcttg gaggagtggc 1322461 cggtccgctt acgctgtatt ggataggccg gtacggagga aggccgtttc ttgaacgttt 1322521 tgggaagtat ctctttatta aacctgaagc gcttgataag tcagataatt ttttcaaaaa 1322581 acatgggggc tttgtcgcct tcagcggccg tttcttgcct ggtatcagga cattgatttc 1322641 cataccgtgc ggaattgcaa aaatgaatgt ttgggtgttt tcgctttata cattcattgc 1322701 tatgcttccg attacatttg tatatgttta tctcggtgtg aagctcggtg aaaattggaa 1322761 ggcagtcggc tctattcttg atcaatatat gcttccgatc gggatagcga ttttggcgct 1322821 gttcctgctc tacttactga tgaaaaagag gaagaaacgc acgcactccg aacaattatc 1322881 tgtatttttg aaaaataaac gttgacaaat cactgcgctg cgcatattat tgacgtataa 1322941 aatcatattt cttgaaatcc caaaggggag tagcgtccgg aatgtattcc ggaaacaaag 1323001 tcgtcatttc atggattgta tccatcggct ttgttggcat gcctgaattc atgtctagca 1323061 agacctttgc cttatgtcgg caaaggtctt ttttgcatgg tccggccggc ataagatcgg 1323121 atgaagagaa agaaaacaac ttttttggga gggtatcatt tatggatgca gcattattat 1323181 tagagtatgg ttgggttctt ctcgtcttga tcgggctgga agggatttta gccgccgata 1323241 acgcgctggt tatggcggta atggtaaaac atttgccgga ggaaaaaaga aaaaaagcgt 1323301 tattttatgg attggcaggg gcttttgttc tgcgatttgg ctctttattt gcaatttctt 1323361 tcttggtcaa cgtatggcag gttcaagcga ttggcgcgat ctatttgctg tatatctcag 1323421 caagccactt attgaaaaga tatgtattta agaaagaaga cacacataaa gagacgaagc 1323481 aaagcggttt ttggccgact gttttaaaag ttgaactggc agatatcgcg tttgctgttg 1323541 attccatctt agcagcagta gcgctggcgg ttacacttcc tgggacatca ctcccgaaga 1323601 tcggcggact tgacggagga caatttctcg tcattttggc cggcggtatc atcggactgg 1323661 tgatcatgcg gtttgcggct tccatgtttg tgaagttatt aaaggaacgt ccaagcctag 1323721 aaacagcagc ctttgtgatt gtcggctggg tcggagtgaa gcttgcttta tatacgcttg 1323781 cccatcgcga catagcggtt gtttctgagc actttatcca ttctggaaca tggaagctga 1323841 tattctgggg tgtcttagca gcaatcgcgg tttgcggctg gtttatgtca ggtgggaaaa 1323901 aacagccgga gggtgcacaa aacgaacaaa aaaacagcac ccgtgaacgg gcgtaatctg 1323961 aaagactctg cttaaaagca gagtcttttt gtgtttgaag cgttttcata agcgaaataa 1324021 aataacattt ttataacatc tttgttacaa aaaacacgca taaaaccccc ttaattcttt 1324081 agaaaggcac gaaatcatgt atagaacgtc agaatggttt gtcataattg agacattgga 1324141 aatcaatatt tctttttctc ctttgcgaat ccctatcaaa ttagctatca ttaatgagta 1324201 gttataggga ggaactgagg tgaaaccagt gcttagcctt ttgtttaaat tgggaaaaaa 1324261 gaagcaaaca cttgaaaaag ctgttgagag tatacaaaaa ggcaataaag atctgcaaaa 1324321 tgaattaata cagcaatata agccatttat cgcaaagacg gtttcatccg tttgtaaacg 1324381 atatatagat gaaaaagacg atgagttcag tattggactg atcgcgttta atgaagctat 1324441 agaaaaatat tcacctgaaa aaggaaattc tctgctcgca tttgctgagc ttattataaa 1324501 aagaaaagtc attgattaca ttagaaaaga agccagaagc gcacaaaata taaatatcga 1324561 tttacaggaa ggagacgatc aggagtcatc acaaagcctg attgaagccg agctttccat 1324621 tgatgaatac cgccgtcaga ttgaacagga gcagaggcgg gaggaaatcc tctattttca 1324681 aaagcagctc aaggattatg gtttatcgtt taaagaactg cttgaaaatt ctccaaaaca 1324741 cacggatgca aggcaaaacg ccataaaggt ggcaatgacg cttgttgaac atgaagaatt 1324801 ggccgctatc ctgtatacaa agaagcagct tccggtcaaa cagcttgaac agcttgtctc 1324861 tgtaagccga aaaacgattg agagaaacag aaaatatatt attgcgatgt gtattatcat 1324921 tacgggtgat tatatttatt taaaagatta tcttaaaggg gtgctgcact catgagaaga 1324981 gggattatag tagagaaaaa taaaaaattc gtcacgttgc tgacccctga cggacaattt 1325041 ttaaaagcca aaaatgatcg acacagctat gaaatcggag aagaaatcat gcttccgagt 1325101 gaaacacgca tgggcagaag ggccagcttt tttgattttt ttaaactgcg ccctttcaaa 1325161 atggggattt ttacgatgac tgctattatg ctctttattt ttatagttct ccccgttttt 1325221 tctaataata aggcctatgc gtatatgaca atcgatatca atccaagcgt cgaaatggcg 1325281 ttaaacagcg attatgaagt gattgaactg acgcctctaa acgatgaggg acagaaagtc 1325341 gtgaatgata tagatgattg ggagaagact gattttaaaa aggtgattga cgatattata 1325401 accgactgca gtgaacacgg gtatgtaaaa aaatcgaaag aaatattgat ttccactgtt 1325461 tatgaaaaca cagaagacaa tacatataaa aaggctgtga aaaaacagct gaatgatgtg 1325521 actgaaaaat ataaaacgac ataccgcatg gaatctctcg agtcagatat gcaaacgagg 1325581 gaaaaagcga agaaagaagg cgtctcaaca ggcagctaca tcaaatcaaa tgaaaagaat 1325641 gacaataaag atataaaaga tgactccagc aaaccatccg gggaagagga tcaaaagagt 1325701 gatgaaaatg aggatgaaaa caccgatcaa actgacaccc aggacagcaa gcaaggagat 1325761 aatgaacagc tgaatgatgc ggattccgga gaccagaaag aagagaaagc ggatgaccag 1325821 attgatgata gtgacaaaga taaaaaaata aaggaatcag atgaaaacac aaataccgaa 1325881 aaagatgggg accatgagca aaccccaata caagatcctc aagataaagg aaatgaaaat 1325941 aacggcgctg acaagggcca aagccaatat cacagggact ggaacaatgg tgaacaaggc 1326001 aagaaccgtt cttcgtccag aagggataac gcttcagacc gacgtaatcc aaacggctac 1326061 agcagtgata atcattcagc taaaaatgaa gattcgccga gtgcccccgg cgaataaaga 1326121 cctgaattta tttagttgtg ccatttaatt gtgattgtgc ttgctgtacc agccgctttg 1326181 tcatttctcc gcctacagag ccgttagcgc gtgcgactgt atcagaacca aggttcacac 1326241 cgaattcttg agccacttcg agtttaaatt ggtctagtgc ctgctccacc cctggaacaa 1326301 cgagtttatt tctgctcgcc atctttttca tctccttttt cgataaagaa attcttaacg 1326361 cgtatttagt ttgaaatata cggggtttat ttatgctggc aattgttgtg gagaaaaata 1326421 aaaccccggc ctctgagccg gggtggcgca gactatagaa tgtctgctgt cattttatgt 1326481 gcggttgcct gaatatggaa tgtcaaaatg gagaggactg taatggcgat aatctgtctg 1326541 attttaagcc attggctgtc attcagttct tcaaaacggt gacggagacg ctctgtctcc 1326601 tgttcggcga tctcctgcag atttgattct ttcatagaag gagtatcttg gtgatggatg 1326661 gcatcaagca catatgcgca gctttcataa taagcaatcg ggctgatgac atcatcagat 1326721 ctgtctgaga ttgtgttaaa ggccactttt aaaatagccc gtatgtgttc aaagtcataa 1326781 atggatttta aatcacgtac aattaaaaga ataactgcct gttcaattga gtattttttg 1326841 cccagctcag ggtgtccgat cagatctttg atatcacgct ttacccagtt ttgaatcgcg 1326901 gttgacttta acgaagtcag ctcgcataag ttgccaagct ctacgatttc atttgtagac 1326961 agaccgtatt cttttttctg tttttttcgt tcgtatcttg taagaaattc aggaatttct 1327021 agatgattgg ctgctttttc tgctgacatg ttcgctgatt ggacgagaat gtcgagcggg 1327081 ctatgttctc cttgtccttt tagggaatag agcagccgca ccatatcggt tcgagagagt 1327141 ttaaaaatgt tcattgttca cctctttaaa caatttgacg cggatatagg tctatgtata 1327201 agttcaaaat tcaagcgtca gcaaattaca ttaacatcat acgtcgaatt ccttgcattt 1327261 tcaaatggat gttttataat ttaaatatac gggttctttt gaacttaaaa taacggaggt 1327321 tgttatggcg aaaagaattt ttctgtttat tctaacgaat attttggtgc ttacaacaat 1327381 cgggatcgtt ttgtctgttt taagctctgt tacaggagtc gggacgtact ttacagctga 1327441 tggcggtatc gatccaatgg cgcttcttgt gttcagttta gtcgttggat ttgtcggttc 1327501 ctttacgtct cttgcgatat ccagatggat ggcaaagacg atgatgggcg tcagagtgct 1327561 gaatccgaaa aaacactcgc tcagctatga ggaacagcaa ttggttgatc gtgttcacag 1327621 attaagccgc tctgccggtt taacgaaaat gccggaagtc gggatttacc gttcacctga 1327681 agtaaacgcg tttgcgactg gaccgtcaaa acgccgttca cttgtcgcag tatcgtcagg 1327741 gctgctggag cagatggatg acgcagcagt tgaaggtgtg cttgcccacg aggtcgcgca 1327801 tatcacaaat ggtgatatgg taacaatgac gcttttacaa ggtatcgtta atacctttgt 1327861 cgtcttttta tcgcgtatcg ccgcttggat agcaagccgt tttgtcaaag aagatctagc 1327921 gccgatcgtt cattttattg caatgattat ttttcagatt gtcttttcga tacttggcag 1327981 cctggttgtg tttgcgtatt cacgccatcg tgaattccat gctgacaggg gaggagcgga 1328041 tcttgccggc aaggacaaga tgattcatgc gctgcggacg cttaaaagct attcttcccg 1328101 gattttggaa gacgatcaga cagctgtcca aacgttaaag attaatggca agaagcgctc 1328161 ttcacttttc tctactcatc ctgatttaga tgagcgaatc agacggctgg aagctaaata 1328221 atacaaacac attgttcctc tgagagaatt ctcagaggtt ttttatttta tccattgact 1328281 aaaatcataa aaaaataagc aagttaagaa aatgtttcgt aaaagccttt aaaaatggac 1328341 ctaatatctt tagaataatt accgtactta aaaagagagg cagaaggatt ttacatgaga 1328401 ttaaagtttg gaaaattgat acaggccttg tcaccggccc agctgatcgc attatattat 1328461 tttcttgcag ttactgtggc cgttatattg ctgagtttgc cggcggccca taaaccgggg 1328521 gcggattgga cgtttattga tgcgcttttt acagctgtca gttcagtcag tgtaacgggg 1328581 ctgacagttg ttgatacagc tgatacattc agcacaatag ggatttttat attagcattt 1328641 gttctgcaat ttggcggaat cggaattatg acgctcggaa cgttcatttg gctgatcatg 1328701 ggaaaacgaa tcgggctgaa agaacggaag ctgattatgg ttgatcaaaa ccaatcccag 1328761 ttttcaggaa ttgtcaatct gatgaagcag gtactgtttc tgatcttgtg gattgaattt 1328821 tttggcgggc tgatactcgg cacatatttc ttaacctact atgactccta tcaggaagcc 1328881 tatttacacg gattttttgc cagtatcagt gcaacgacaa acggcggatt tgatattacc 1328941 ggtaattcga tgattccatt tcgccacgat tactttgtgc agtttattac aatgctttta 1329001 attatatttg gagcgattgg atttcccgtg cttgttgaag taaaggattt cctgttttca 1329061 aagcatcggc gttatccatt tacgcttttt acaaagatca cgacgattac gttcggctca 1329121 cttgtcttgt ttggagccat tggcatcttt gccctggaag caaaccatgc gttcgcagga 1329181 aaatcatggc atgatatttt gtttttgtcc ctgtttcaat caacggcaac ccgaagcggg 1329241 gggctggcaa caatcgatat cagccaatta tcagattcca cactcttttt tatttgtgcg 1329301 ctgatgttta ttggagcgtc gccaagctca gtcgggggag gcataaggac aacgactttt 1329361 gctttgaacc ttcttgcgct gtttcatttt gcccgcggca ataaggccgt aaaggtattc 1329421 aaacgggagc ttcaccctgc tgacttgatg aagtcgcttg ttgtcacgat gatggcgatc 1329481 ctgctcgttt ttggcgcgac actcattctg accattacag aaaaacattc cctgctggag 1329541 cttttgtttg aagtgtgctc ggcattcggt acaaccggcc tatcgcttgg aattacggca 1329601 gatttgagca gtgttggaaa atgcgtcatt atgattgtca tgtttatcgg gcgaatcggc 1329661 atcttgacct tcctgtatct gatcggaaga aaggaaattg aagcgaatta tcactatccg 1329721 aaggaaagag tgattatcgg ataggcaaaa caccgcatat tttgcggtgt tttttgatta 1329781 ccaaaaaaaa gatgtgtgcc tcctgttcag ttggagaacc taactccgac aggtgcaatt 1329841 tacgctcctg catcttaaaa tgtctgaaaa ttggcgagga ggattcgtat gaagcgtaaa 1329901 gctgaagtga atgaagccat taaaaataac aatacaccta ccgagagcat ggaccccaat 1329961 tcatataaga cacaatatca tgacgacccc aattttagag gggcaaaccg caattccaaa 1330021 cagggccagc agggaggcat gtaattgtga agaaaaaccg tcatagcaga gacatgcaaa 1330081 atcataaaaa gcctatgaat aaaaaggtgc tggaggaaga attctcaagt gaactcgggg 1330141 attacaatgc cggaaagatc atcgaaacgc tggaagtcac caagcctgaa aagaaaaaag 1330201 aaaaaaacaa aaaacaacaa taaaaaagac ctcttaggcg gcgtcccgct taagaggtgc 1330261 tttttctatt ttaaataagc atttttgccc gttcctctga caaattgcaa taagcttgtc 1330321 atcctcagct caatgaatgg ctgagcgact gtcttaacaa agttgctgga gaggactgat 1330381 gtcagggctg ctgttaaaag caagaggatc actaagcttt gatagtcagt aagccaatcc 1330441 tcaagcccga cctgccgtaa tgtcttaata ataaacccgt gaagcagata cacgtaaaat 1330501 gtccgggttc cccatttggt aaagaaatac cgtttttgcg gaacgagcgc taaaaagctg 1330561 aaggttgccc caaaggcgag tacataccag ccgattcggg atagtccgct taccagggta 1330621 acgtctccaa atgaagaata cggttttgaa ccaaacagaa aagaatagtc aaaatcgatg 1330681 ccccagcaga tgacgaatac tgcggcaagc actccgagcg caatttgttt gccgcgtttt 1330741 gatctcaata aatcaaaatg atgtttattt aaataaaaac cgacaaggaa catcggtaag 1330801 aatacgaatg tccgtgacaa gctcagcgtg ctgctgacaa agtccagata accgatcagc 1330861 acggcgattc cgcagctgac aaacagcgcc cactgctttg aaagctttga aaaaggatat 1330921 aggagcaggt tccaaaagaa taagcttaca agaaaccata acgaccattg cggatcaatc 1330981 gggttcacat ttgccatgct ttcatcttgc ataatgtaat aaaagacgga ataaataatt 1331041 tggaaaatca aatacggaat aatcagcttg accgccagct tttttacata tcccgcccgt 1331101 ttaaagcctt tcgcgaaata accggataca agaataaatg caggcatatg gaatgtgtaa 1331161 atgaacttgt agaggtagag cataaaatga ttatcattaa taaaggaacg aaggatatga 1331221 ccgaatacaa caaggaatat caataaaaat tttgcgttat cgaaataact gtcccgcgat 1331281 ttactcatag catcaccttc tctttcatca gtcactaaga gattattccc tgctggtaca 1331341 tattttaaaa taaaagatga aaaaggaatc taaaaaaatg ctgattgtta ggtcgatgta 1331401 aagtgacggt aaggatcgta gaaaatgtct tcgtaatgta atgacgctga aattttctga 1331461 aatttatagg gcaaatgaag gaagttcccg cattttgtag aaatattgag ggataggttt 1331521 tgaagaagga gtgtacatgc atggaaactc ttggtgtcca gacaaactcg gagctgcgag 1331581 aggaactgaa tcgcctcaaa gaagaaaacg cgcgactgaa aaaggaattg aatcagcatc 1331641 aagtgattgt caacaatacg ctcgatgcta tttttatttg tgataacgaa atgcggattg 1331701 ttcaggcaaa tgaagcaaca gaaaggatgc ttcaagttga ctcggaagat ttgaaaaagc 1331761 gttctgtttt ggattttttg ttttcaatcc caaaggatga actgaatctt tccgtaaaga 1331821 agttttttaa aaaaggcttt ctgtggaagg aggttccgat caggcttgat tgcggggcaa 1331881 caaaatacat agagtttctg gccaaaagag gtattggtga ggatttcttt tttgttgtca 1331941 tgagggacat atcttctaag aagattctgg agcgggaatt ctctatgaat gaacagcttt 1332001 ttaaggactt gtttgacaga gcagttgacg gaatcgtcct gtttgataaa gatggcggtt 1332061 ttattgatgc aaatttgtcc ttttgtaaaa gctttgaaat caatcataat gagctgtctc 1332121 atttatcttt gtatgagttc atagacagcg gctcacgaaa agatttcgac aatatctgga 1332181 aggcgctcaa ccgcaaggga aaagcgaagg gggagctgcc tgtcaagctt cgttcaggag 1332241 ttcaaaaact atttgaattc acgattacat caaacatcat cagcggtttt tatatgtcca 1332301 ttatgaggga tatcacagag aagcggtcta tggagctgca gctctttaaa agtgaggagc 1332361 gcttcagaga aatctttgaa aatgcaatgg acgccatcat catctggtcg aatgacggaa 1332421 gaatcgtaaa agcgaatcaa tcagcctgta aaatttttga gctgccgatg aatttgctgt 1332481 tgaaaagaaa gctgtgtgat tttctcgttg actcgcagca gaaatacagc ataacgaaga 1332541 ggaaatacgc aaaatacgga gagatcagag aagagctgct gtttcaaatg gggaacggcc 1332601 aattcaaaga gcttgaattt acttcaaaac ggacaatcct tgaaaatcag catttgacga 1332661 tcttaagaaa tgtaagcgac agaaagcgga tggaaaagga gcttcgggaa agcgagctga 1332721 aattcagaaa agtgttcaac ggatcaatgg acggcaatgt attgttcgac aatcaataca 1332781 ggatcatcga cgccaacccg ttagcaagcc atattttggg cctgtcacat gaagagatca 1332841 aacagcacag cctgttagat attatttctg cttatgaaat agaaaatttg gcatcaccgg 1332901 caaggcagat taattttgat gaaatggaca acgaaattcc atttttgctg agcagcggtg 1332961 ataacagaaa actcgaattc tcatttaaac ggaatattat tcaaaatatg aacttggcta 1333021 tctttaaaga cgtaacagag cgaaaagaat tggaggagcg cctgcgcaaa tcagataccc 1333081 ttcatgttgt cggcgaactc gcagccggta ttgctcatga aatcagaaat ccgatgactg 1333141 ctcttaaagg cttcattcag cttctgaaag ggagtgtcga gggagactac gccctttact 1333201 tcaacgtgat cacctcagaa ctaaagcgca tcgaatccat catcaccgaa ttcttgattt 1333261 tagccaagcc ccaggccatt atgtatgagg aaaaacatgt tacccaaatt atgagggaca 1333321 cgatagacct tctaaatgcg caagccaatc tcagcaatgt acaaatgcaa cttgatttaa 1333381 ttgacgacat tcccccgatt tactgtgaac cgaatcagct gaaacaggtt tttatcaata 1333441 tattaaaaaa cgccatcgaa gtgatgcctg acggcggaaa tatttttgta acgataaagg 1333501 cattggatca agatcatgtt ctaatctcct taaaagacga gggaatcgga atgacagaag 1333561 ataaattaaa gcgacttggt gaaccgtttt atacgacaaa ggaacgggga actggacttg 1333621 ggcttatggt aagctataaa attattgaag aacatcaagg cgagattatg gtagaaagtg 1333681 aagaagggaa gggcaccgtt ttccatatta cgcttcctgt cagacagaat gctgaagaaa 1333741 gaaggaatga tgaatgaact actatacgac agccgaaacg ccgctcggtg aacttatcat 1333801 tgccgaagag gaggaccgga tcactcgtct atttctcagt caggaagatt gggtggattg 1333861 gaaagaaacg gttcagaata ctgagcataa ggaaacacct aatcttgcag aagcgaaaca 1333921 acagcttcaa gaatatttcg caggcgaaag gaagacattc tccctgccgc tcagccaaaa 1333981 gggcactcct tttcagcaaa aagtgtggca agcgctggag aggattccat atggcgaatc 1334041 ccgaagctat gcggatattg ccgctgctgt cggcagtccg aaagcggtgc gcgctgtcgg 1334101 gcaggctaat aaacgtaacg acctgccgat ttttgtcccg tgccacagag tgatcggcaa 1334161 aaacagtgcg ttaacaggat acgccggaag caaaacggag atcaaagcat ttttgctaaa 1334221 catcgagcga atctcctata aagaaaaata aaacatatgg cacgttccct tttttcacgg 1334281 ccgacatatc attttattaa gttaaaaaag ttggtctgat gaaaaaggag gacaaagcaa 1334341 ttgaagccga gccgctctga gaaacttgcc gtttttgccg aactgtttgt gaaactgcat 1334401 atcttatcaa gcgctcaaaa agatgaaatc atcaatgtta acaaaaagaa acaaaaaaac 1334461 cgctgactcg gctccaaatg agcaaagtcc agcggttttt taatgcacct tttctccttt 1334521 aaacagctgt tcaatctctt cttcatagtt tccggtcata atcccttttt ctgtgatgat 1334581 tcctgaaatg agatcatgag gtgtaatgtc gaaagcggga ttaaagacag gcacattgga 1334641 tggagcggtc cgaactccgg aaatctgcct gacttcctcg ggatctcgtt cctctatcgg 1334701 gatatcagcg ccgcatttga cctttgtatc aaatgtagat aaaggtgcgg cgacaaaaaa 1334761 cggaatatca aaggcgtttg ctaaaatagc aagaccgtat gtgccgattt tatttgccgt 1334821 atcaccgttc tttgcaattc ggtcggctcc gacgataaca gcggaaattt gtttttcctt 1334881 catcgtatgg gcggccatgc tgtctgtgat cagagtgaca tcaatgcccc cctgcatcag 1334941 ctcccaagca gtaaggcgtg aaccttgcag gacaggcctt gtttcacagg cataaatgtg 1335001 taatcccaaa tctttttgtt tggccaagta aaacggagct agcgccgttc catagcggct 1335061 tgtcgcgatt gagccggcat tgcagatcgt catgatcctg tcgccttttt tgaaaagctg 1335121 cagggcgttt tggccgatca accggcacgt ttcctcatcc tcgacctgaa tctgaatggc 1335181 ttcatggaca aggtttgttt ttgcttcatt tacggaaatc gcgttttcga ccgaatgact 1335241 cagtctctca agcgcccatg acaaattaat ggcggtaggc cgtgagctgt ttaaatattg 1335301 tttgatgtct tccagtctgc ggcggaattc cgtgacattg tctgtttcaa tgtctttggc 1335361 agcaagcgcc agtccgaagg cagctgtaat gccgatcgcc ggagcgcccc ttactttgag 1335421 cgtgacaatc gcatcaaata catcctcttt cgtcgtcagc tccaaatatt ccgtctcatc 1335481 aggaagcttt tgctgattta aaatggtaat agctgtttct ttccattcaa cagaacgtgg 1335541 aacagcaaat gaatgggtca tgaatagatc attcctttac aagtaactta aataattcaa 1335601 taacatctgt tatcgttttg aattccgaac gtttttcgat aaaggctgtg ccggtttcga 1335661 gcgccaagcg ttttctgccg attcgtttat caaacggcac gatcgtatcc aggtcagcta 1335721 catgggcaag gccgatcgtg cgtcgtatca gctcacagcc cgcaaatccg attgcttctt 1335781 caaaaatatg gctgagcgta tcagtgaggt aaccgtcgat gttggcgtaa acatccagac 1335841 tgtccttctg ccaggcttca ctaaacgtct cttcaaacgt ttcccagacc tggttgacat 1335901 gttcatataa cggctctctg tcagccccgt cacggctgag tgcgttcaaa aataagttgg 1335961 cgataaattg ccctacatca aagccgatcg gtccgtaaaa agcaaactca ggatcaatca 1336021 cctttgtttc gtgctcactt gcgaaaatgc ttcctgtatg caaatcacca tgaatcaacg 1336081 tttctgcaga cgttaaaaat gactttttca gcttagcggc ttcgatttta acgctgtcat 1336141 tattccaaag cttttcgaca aaaggacgaa gctcttcttc aaaatcattt gtgtcatggt 1336201 cgaagaaagg atctgtaaaa acaagtcttt ccgtaatgtc gcatagctct ggatttgtaa 1336261 actgtttaac aagctgtttt ttcaccttag gttcaagcgc gtaatctgat gagtagaaaa 1336321 gtgtttttcc taaaaattca ccgatgtgct gcgacagatg aggatagttt tcaccctcaa 1336381 tgagtccttt tcttgcgatc ttgaggtgag agagatcctc catgacggta accgccattt 1336441 ccgtatcaga ataaaacact cttggaacca ggtgaggcac atgctcgccc tgacggatga 1336501 gagcgctgct ttcgattctt gcacggtcga ttgtcagcgg ccagctttct cccaccactt 1336561 ttgcatacgg aaccgcctgt ttaatgatca atgctctgtc atgttcttga tcataaatat 1336621 gaaaaacgta atttaagttg ccgtctccga tctcctggca tgtcagcgtg cttttgcttg 1336681 gaaataggcc aagcttcacc gccaacgcca cagcggagct ttcatttaac gtttcgtata 1336741 aaggtgtttt tgtgactccc atcatcataa cctccaatta tgtaattaat taatatgtgg 1336801 ccgtaaaaaa gcctccttct cagagagaag gaggcttaac atctatgtcc gcctctctta 1336861 tctctcagat cagatctgaa tggaattagc accgtgcctt aagagaccag cgtctcggcg 1336921 cgaaaaaaat gcgccccatt tcacaatgga attacggtcg gttgcttttg gggtcaaaag 1336981 gccaaatccc tcgcccaact ctcgataaga gaatatattc acttgtttga caattctaat 1337041 ttatcagttg atgaacatgg taacaggtaa tttagttagt tgtcaatata ttttttaata 1337101 taaatctttt ctgatatcat cgaaaacagg aatgctctcc cgaacttctg cgctttcttg 1337161 aaggtcgatt tccgctcgga ctatgccttc ttcccggccg ccttcagcaa gtacacgtcc 1337221 ccatggatca ataatcaggc tatgtcctgc aaattcatta tccggatttg aaccggtaca 1337281 attgcaggct gcgacaaagc attggttttc aatggcccgc gcaataagca ggcttttcca 1337341 atgatcaagg cggggaagag gccattccgc agaaataaac agcacgttgg cgccttttgt 1337401 cgtatgtttt ctgatccatt ccggaaaacg gatatcgtaa cagatcaatc cagagctttt 1337461 gacgccgtca agctcaaagt atccgtcttc ggaaccggct gataaataca gatgctcatc 1337521 catcagctga aaaagatggg cttttctgta ctctttaatg atttgccctt ccttatccgc 1337581 gatgtacatt gtattataaa catcagaatt cttcctgaca gcgaccgatc cggcgacaat 1337641 atgaacacca tgtttttttg ccgttttctt cagccagctc tgagcggagc ggccgtcttc 1337701 gtcagcgagt tcatcaagat tggccagatc atatccggtc gtccataatt caggcagaac 1337761 aagaacatca gcatgtttgc tttctttttc gatgaaaaat tcagcctttt ttatattttc 1337821 cgaaggtttt ccgtatgaaa tatcaaattg aagacaagat atcgtccatt tcatcttttt 1337881 aacaccccaa atttttcttt acttttttca tttaaccata tatgatgatg gactatcatt 1337941 tcaagatttt tttagaaggt gagaatagat gaaatttgaa cagtctcatg tattgaagga 1338001 attgcctaaa caattcttcg cttctctggt gcagaaagtg aaccgaaagc ttgcagaagg 1338061 acatgacgtt atcaatctgg gacagggaaa tccagatcag ccgactcctg agcatattgt 1338121 tgaggagatg aaacgagctg tcgctgatcc tgagaatcat aaatattcgt cttttcgcgg 1338181 ctcataccgt ctgaagtcag cggctgctgc attttacaaa agagaatacg gcattgatct 1338241 ggatccggaa accgaagtcg ctgtattatt cggcggaaaa gccggtctag tcgagctccc 1338301 gcaatgcttg ttgaatcccg gtgatacgat tttagttccc gatccgggtt atcctgatta 1338361 ctggtcgggt gtcacacttg caaaagcaaa gatggaaatg atgccgctcg taaaggacag 1338421 agcgtttctc cctgattaca gcagcataac cgctgaaata agggaacagg cgaaattgat 1338481 gtatttgaat tatccgaata atccgactgg agctgttgct acttccgagt tctttgaaga 1338541 taccgtgcgt tttgcggctg aaaacggaat ctgcgtcgtt cacgattttg cttacggcgc 1338601 tgtaggattt gacggctgca agcctttaag ctttttgcag actgaaggtg cgaaggatat 1338661 cggaattgaa atttacacgc tgtcaaaaac gtataatatg gcaggatggc gggttggctt 1338721 tgccgtcgga aacgcttcgg tcattgaagc gatcaatctt tatcaagacc atatgtttgt 1338781 cagtcttttc agagcgactc aggaggctgc agcagaggca ctgttagccg atcagacgtg 1338841 tgtggcagag caaaatgcca ggtatgagag caggagaaac gcttggatca cggcatgccg 1338901 ggaaatcggc tgggatgtaa cagctcccgc aggttctttt tttgcatggc tgcctgtgcc 1338961 tgaaggctat acttctgagc agttctcaga tcttttgctg gaaaaagcga atgtggcagt 1339021 tgcggctgga aacggcttcg gtgaatatgg cgagggctac gtcagagtcg gacttttaac 1339081 aagtgaagaa agacttaagg aagccgctta tcgaattggc aaactgaacc tgtttaccca 1339141 aaaaagcatt gacaagacct tataacgatg ggataattca aaataattta taaaatctat 1339201 attttcttat caagagcagg cagagggacg agcccgatga agcccggcaa ccgacttata 1339261 aagcacggtg ctaattcttg cagctagcgg ctgagagata agattcggac gagaaacgaa 1339321 acctctttag acgcgattgc agtttgaaga ggttttttga tatggatgaa aatgaaagga 1339381 gctctggcat gagtgagtta ttagcgacat atctcctgac cgaaccggga gccgatacag 1339441 agaagaaagc agaacaaatc gcaacaggat tgacagtagg ctcctggact gatctgcccc 1339501 ttgtaaaaca ggagcaaatg caaaagcaca aggggcgggt gataaaagtt gaggagagag 1339561 agggaactgc tgcatcagaa aaacaagcgg tcatcacaat tgcctatcct gaaatcaatt 1339621 tctctcagga tattccggct ttgctgacaa cagtgtttgg caagctgtcc ctggacggaa 1339681 aaatcaaatt aatcgatctt cacttctctg aagcatttaa gcgtgcactg ccgggaccga 1339741 agtttggcgt atacggcatc cggaagctgc tgggagagtt tgagagaccg ctgttaatga 1339801 gcatatttaa aggcgtaatc ggaagggacc tgagtgatat taaagaacag ctccggcagc 1339861 aggcgcttgg cggagttgac ttgattaaag acgatgaaat tttctttgag actggtctag 1339921 cgccttttga aacaagaatt gcagaaggaa agcaaatatt gaaagaaacg tatgaacaaa 1339981 ccggacataa aacgctgtat gcggtgaatt tgaccggacg tacggctgat ctgaaagaca 1340041 aagcgagacg cgccgccgaa ttgggagcgg atgcgctttt gtttaatgtc ttcgcttacg 1340101 gcttggacgt tatgcaaggc cttgcagaag atcctgaaat cccagttccg attatggcgc 1340161 atccagcagt gagcggagcg tttacgtctt ctccgtttta cggtttttct cacgctcttt 1340221 tactcggaaa attaaaccga tattgcggtg ctgacttcag cctctttccg tctccatatg 1340281 gttcggttgc gcttccaaga gcagatgcac tggcgattca tgaagaatgt gtgagagagg 1340341 atgcttttaa ccaaacattt gctgttccgt cagcaggcat tcatcccggc atggttccgc 1340401 tattaatgcg tgatttcggc atagaccaca ttattaacgc cggaggaggc gtacatggac 1340461 atccgaacgg tgcccaaggc ggggggcgag cgttcagagc tattattgat gcggtcctag 1340521 aggcccagcc gattgatgaa aaagccgaac aatgcaagga tcttaagctt gcgctagata 1340581 aatggggaaa ggctgaagcc gtatgacgac tcgaaaacct tttattattt gtgattttga 1340641 cggaacaatc acgatgaacg acaacattat aaatatcatg aaaacatttg ctcccccaga 1340701 gtggatggca ttaaaagacg gcgtactttc caaaacgctg tcaatcaagg aaggtgtcgg 1340761 gcggatgttc ggccttctgc ccagcagttt aaaagaagag attacaagtt ttgtattgga 1340821 agatgcaaaa atcagggaag gctttcggga atttgtagca tttatcaatg agcacgagat 1340881 tccgttttat gtcataagcg gtggaatgga cttttttgta tatcctttgc ttgaaggcat 1340941 tgtggagaaa gaccgcattt attgcaacca tgcttcattt gacaatgact atatccatat 1341001 tgactggcct cattcctgca agggcacatg cagcaatcaa tgcgggtgct gtaagccgtc 1341061 ggtcatccat gaactttctg aaccgaacca atatatcatc atgatcggtg attcggttac 1341121 agatgtggag gcagcaaagc tgtctgacct atgctttgca agggattatt tattaaacga 1341181 atgccgggag caaaacctca atcatcttcc gtatcaagat ttttatgaga tcagaaagga 1341241 aattgagaat gtaaaggagg tacaggaatg gctgcaaaac aagaacgctg gcgagagctc 1341301 gctgaagtaa aacgggaatt ggcagagaga gattggtttc cggcgactag cggcaatctg 1341361 tcaattaagg ttacagatga gcctttaaca tttctcgtca ctgcaagcgg aaaagataaa 1341421 cgcaaagaga cggttgaaga ttttctgctg gtcgatcaaa acggagagcc tgctgaaagc 1341481 gggcattctc tgaaaccgtc agcagaaacg cttttgcata cacatttgta caataaaacc 1341541 aatgccggat gctgcctgca tgtccatacg gtaaacaata atgtgatttc agagttatac 1341601 ggagaccaaa agaaaatcac attcaaaggc caggaaatta taaaagcact cggcttgtgg 1341661 gaagagaacg cagaagtgac cgttccgatt atagaaaatc cggcacatat cccgacgcta 1341721 gcggcactgt ttgcggaaga gatttcagaa gattcaggag ctgttctgat ccgaaatcat 1341781 ggtattacgg cttgggggaa aacagcattt gaggcaaaaa gagtgcttga agcgtatgaa 1341841 tttttgttca gctaccattt gaaattgaaa acactcgagc atcagctggt taaataaaag 1341901 gaggaattga aatggctaca attcgaattc atgatgaggc aaatacaacg attgaaaatc 1341961 aagaggaagt ggcaagcttt ctggacagtc aagaggttat ttatgagcaa tgggatatca 1342021 cgaggcttcc ggaacatctc tcagagaaat atgacctgac agaagaagaa aaacagcaaa 1342081 ttcttgatac cttcgaaact gaaattaaag atatctcaac ccgccgcggc tataaagcac 1342141 aggatgttat ttcattgtca gacagcaatc cgaaacttga tgaactgctt gaaaacttta 1342201 aaagagagca tcaccataca gacgatgagg ttcgttttat tgtaagcgga cacggtattt 1342261 ttgtcattca aggccaggac ggcacgtttt ttgatgtccg tttaaaccct ggagatttaa 1342321 tctccgtgcc tgagaatatc cgccattact tcacgcttca ggaggaccgc aaagttgtcg 1342381 cggtgagaat ttttgtcaca actgaaggct gggttcctat ttatgaaaaa gacagcgtga 1342441 atcaataagc gtgagatagc cccgttcatc gaacggggct ttttatattt attgcaaacg 1342501 ccacttttca tattgtgaca gttctttttt aatcagtgtc caaatcaaac ctaaaacagc 1342561 tgcatcgtca atgaatccaa gaccgaggat tacgtctgga atgatatcga gcggcatgac 1342621 gatatacagg attgcggcag ttaacagcaa aagtgtttta acctgtgaac gagggtagtc 1342681 gccatttcgc caatcgcgaa gcatctgaaa aaaagtagtg atgtgctgga tacatttttt 1342741 tcggtttttc ctctttaaaa tcgcttttcc gcctgccgct ccgagcatta ttgctttctt 1342801 tttcttcatt gggcatacct cctgcctggc ggcgtgttta agatattctt cacctgggta 1342861 ttgttcttct aatcctatca atatatctat tatacctgaa aaattaactt atttaatgaa 1342921 aatatgttta caaataaagt ataatctgta ataatgcaca ataacccaat caaacttgtt 1342981 tcctatttct tagcggcgag gggtgaagtg aatgggcggt tcttctgaac aagaaagatt 1343041 gttggtgtct attgatgaaa aaagaaagtt aatgatagat gccgctagaa agcagggatt 1343101 tacagggcat gacacgatca ggcacagtca ggagctggat tgtttaataa atgaatatca 1343161 tcagcttatg caagaaaacg aacattccca agggattcaa ggccttgtaa agaaattagg 1343221 cttgtggccc cgcagagatg ttatgccagc atatgatgca aataaatagc ggcctatcag 1343281 atgcatatat aaagagagag cttttcggaa gcgctctttt tttctggaaa aaattcatat 1343341 gaaagaggga actaatgaag gaactggcga ttctcattac cgaaatggtc aatcaatttc 1343401 atgatgcttt tatttcctta tgcggaatat ttggcattca tttaactgac aaagaaatgc 1343461 atttttgggt gatcggcatt tttggcatat tctttttcgg cgtcactcac gctgtgttta 1343521 catggctttc taaatggagt atgacagcct tgtcctttat ctataccgtt acagtcatca 1343581 ttgtcatcgt atttgcgatt gagattcagc aaaaggtgac ggggagaggg aatatggagt 1343641 ttttagatgc cacggaaggt ataaagggtt ttttagtatt ttttatgttt tttttgcttt 1343701 tgaaaatgct gttgcgtttc atcaaaatcc ttttttctgg aagaccagca agcaaatcga 1343761 atggcaatgc ccgatcacga agataaaaaa ccctcctgac atggtcaggg gggctatgat 1343821 gcggatacgg ggagggtgat cgtcacctct gtgcctcttc gcacttcact ttcaatatga 1343881 atagagcctc cgtacatcag cacgatccgt ttacaaacaa caaggccgag accggttcct 1343941 ttttctttag aagtaacaaa gggaaggaag atgtgatcca gcatttcctg agaaatccct 1344001 tcaccgttat ccacaacttt gattatggct tttttatcta aagctcctag ggagatcgtc 1344061 agtttgcctc cttcaggcat tgactcgagg ccattttttg ctacatttaa aatcacttgt 1344121 ttaatatgat cttttgtaca ttttacgagt aagggctgct cggttagata ctgtaattcg 1344181 acttcaacat tgtatagatt gccctcagaa taaatgatcg gcataatttc tccgataatg 1344241 tcctgaagtg agttcagctc ccatttttca gctgtcggct tgccgagaac gagaaactca 1344301 ctcactattt gattgatgcg ctttatctcc tgttcgataa tggagaagta aagctgatct 1344361 tcctcacctt tatatttctt ttgcaacagc tgaataaagc cgcttatccc ggtgaggggg 1344421 ttacggattt catgggctgt gctggcagca agcgtcccga tcagctctaa tttttgcgcc 1344481 tcgttttctg agcgctccag ctgggtctgc cgcttcagca aataatacag cacgagaata 1344541 aaaaggatat tcagcagaac aataatacat gaaagcggaa gcacaaggct tttcgacagt 1344601 tcttctattg tgaccgggtt cggatagact ttcatattcc agctgatatc atccagatat 1344661 ccgctgacag gtttctgatc ctctgcatga gaggcttgtc cgctcgcaaa aatcattttc 1344721 ccgtcttggt tcacaacttc aatataaaca tcagggctta gtaagttaat gagatttttc 1344781 aaataatcaa tttgaatagc tgcgacaaga taatctgtca cattacgttt tgagtccaaa 1344841 acaggcacac aaattgtgaa aattggctga ccagtaattc tgctcgaata actatctgaa 1344901 atgactgtct ttttagtttc ctttgctttt ataaaaaaag atctgtcggc caggtttact 1344961 ttcgttttta attcggttgt gcttgcggtg acgtctcctt tggcattgag aaaatagaga 1345021 ccggaaaatc tcggctctga atcaaaggtc ttttccaaaa ttgattgcat tttctttata 1345081 tcaaccggtc tgtcgatggc gatggacaag gaggtcattc tcgccattgt ttctccgatt 1345141 aaataattga ttttgttgcg gtgaaggttt agcaggacac ttgcttcttg tttatgttct 1345201 gcagctattg tatctttttc tttttcatat acgaaaaagc tgatgacgat tgccggaatc 1345261 acgaccagta tgatataaag tttgactctc ccgcaggcgc cttttagtat tttcaatttg 1345321 catcgctcca acatacacct gattagaggt attatatcat tgtttcttct tctttaataa 1345381 gaaaaaataa ccaaaaaaat tagaaaaaga tgttggcaag cttacatttt aaaaaagaag 1345441 agaaatattg gaaagatttt tattgacatt ttggtctttg tttattaatg tttctctgta 1345501 acggtttcta aaaggatgat tgagacatga cagaaaaatc actgaagtta tttatcgtgc 1345561 tgtcgcgcgc gtatcggtct attaacgatc atatgaataa gcatattcat aagcatgggc 1345621 tgaatccgac tgaatttgct gtgctagagc ttttgtacca taaaggcgat cagccgctgc 1345681 agcagatagg agataaaatt ctcttggcta gcgggagcat cacatacgtt gtagataagc 1345741 tggagcaaaa agaacttctc attcggaaag cgtctcctac agacagacga gtgacatttg 1345801 cgcaaattac tgaaaaaggc atcggtcttt tgaacgatat tttccctgat cacgctgctg 1345861 aaattgatga aatgatcagc gtattaagcg aagaagaggt agagatgtgc accgaaatgt 1345921 taaaaagagt aggattaaac gcaaaacagt ttcataataa gtaaaaaaag gaagcctgat 1345981 atgtcacaag gcttcctttt ttgctatttt tcatttgttt ccgctgcgcc tctcggcaaa 1346041 atgagaactt caacccgccg gtttttgctt cggccttccg cagttttatt ggaagccacc 1346101 ggtttatact cgccataacc cttggcgctg aacacttttg catcgagctt ggggttttca 1346161 atcaggagcc ccataaagtt taccgctctc atgacgctta aatgccagtt tgattggaat 1346221 tcagaatttt taattggcat attatcagta tgtccgctga taatgatatt tcttggcggg 1346281 ttaatcacaa gaagatttga aatctctttt gcaagcggca catcttcctt acggatggtc 1346341 gcttttccag aatcgaagaa gatgctgtct ttaatcgtaa tcagaaggcc ttcactagtc 1346401 atcttcgtct ccagctgatg ttccagcttt ttatctttga tgaacttttc cacctggctc 1346461 ttcacatttt caagttcttc ttgatcagct gctttttctt tttctttctt gtttttctct 1346521 ttctcttctt tttccttttt cacttcatcg atgccgtctg actcgttttc aggaggagtg 1346581 acactggagt agtccagtac accggttccg cctgtaaaaa cttcattaaa tgattttgag 1346641 agcatttgaa acttagctgc gtcaatcgag ctgctcgcgt acagcacaat aaacaatgcc 1346701 aggagaagag taaggatgtc ggcgtaagga acgagccatg attcatcaac gtgctcgtcc 1346761 tcatgcttct tcttcttttt tctcgccatt ttgcgcctct ccttgttctg caaatttcaa 1346821 gcggtccttc gcaggaagat acattaaaag cttttgttcg atgactttcg gtgcttgtcc 1346881 ttctaaaacg gataaaacac cttcaatcat gacctcacgc agttttactt cctgttttga 1346941 ttttcgtttt aatttatttg cgaaaggatg ccataacaca taccctgtaa agataccgag 1347001 aagtgtggca acaaaggcag cactgatggc gtgtccaagc tcatctgtgt tatccatatg 1347061 agagagagcg gcaatcagcc cgattacagc gccgagtact ccaagtgtcg gagcgtacgt 1347121 tcctgcttgt gtaaaaatag cggctcctgc ttggtgcctg tcctccattg cttcgacttc 1347181 ctctgtcata atatctctta taaattccgc gctttgcccg tcaacagcca tgctgagccc 1347241 gtttttcaag aaagcatcat ctacatcctc aatgcttgct tctaaagcaa gcagaccttc 1347301 gcggcgtgca agctgagccc attcagagaa cataggaatg agttcctcta ttgtgagctg 1347361 tttattttcc ttaaataaca ctcgaaacag cgtaggcact tttttaattt cttttgttgg 1347421 gaacgcaata acgactgctg agattgtccc ggcgataata attaaaatgg cagcggggtt 1347481 tgcaagggcg ctgaaactga cgcctttcag aaccatcccg acgctcaatg ccacaaaagc 1347541 aagaataata ccgattaacg aagttttatc catagttttc accaaatcct tttttactag 1347601 cttgtctatg gttaatatcg gttttggtgc ccggaacttt agggacattg tgaatttgtt 1347661 catgaaatat tcaaggaaga ggcatagaag ggagaaataa acaaaaacgg gctctccaaa 1347721 attgaaaagc ccgggggtct actgaaatta gcagcttgct tgcaagctgt ccttcagatg 1347781 gtattcatat aatagtagaa atacatattc actgtatata aacatgttcc atccctcctt 1347841 aaaaaagtgt aaaggatgaa gggaagtagc gcttcaggag aagggacggt aatttctaag 1347901 tcaagagtat gaaagtataa aaaaaagcgg cttcctaaaa ggaaaccgct gattgttatt 1347961 ttgctcgcac tttgatttta tcatcttcta aaatcacgtg aaaacttgtg atctcgccat 1348021 tatcaagcag cagatcggtc atttcatcct caacccattc ttggatggtt cttctaagcg 1348081 gacgtgcacc gaatgaaggg tggtagccca gctcagcgat tttttctttc gcttcatctg 1348141 tcacattcaa gctaatgccc cgttccgcca atgtttcttc aagttctcca agaagaaggc 1348201 tgacgatttt gacaagatgt tctttttcca atgagcggaa ctcaataatg ctgtcaaaac 1348261 ggttgaggaa ctcaggttta aagaacatgc tcagtgaatc aattaatgtt tgttcttcga 1348321 tgacactgtc atctgattgg aaaccgactt tcgtttgttt ctcaccagca cccgcattac 1348381 ttgtcatgat gatcacagtg tctttgaagc ttacagttct gccttggctg tctgtcagac 1348441 ggccatcttc cataatttgc aggaacatat gctgaacgtc tgggtgtgct ttttcaatct 1348501 catccagcaa cacaatgctg taaggattgc ggcgcacctt ctcagttaat tgtccagctt 1348561 cctcatggcc gacatatcca ggcggtgaac cgataatttt agatacggcg tgtttctcca 1348621 tgtattcgct catatcgagt cggataatag cgtcttttgt gccgaataat tcatctgcca 1348681 gtgttttaga aagctctgtt ttccctacgc cggtaggacc gacgaagagg aaggagccga 1348741 ctggtctgtt tttggatttt aatccggcgc ggcttcgtct taccgctttt gccacttttt 1348801 gaacagcggc ttcttgtccg atcacgcgtt catgaagttt tgcttcgagt tctttcattt 1348861 tcgtttgttc gtctgcctgc agtttgccga cagggatgcc tgttttttgt tcaacaattt 1348921 cctgaatgtg ctcagcttcc acagtgacag cggtatgagc ggaggagctg ttcagttttt 1348981 tctccaatgc gagttcttca tcacggagtt ttgccgccag ttcgtaattt tcttcttcca 1349041 gggcttttgt tttttcggct tcaattgcag ttaagcgttc agcggcatcc tcatcattca 1349101 gttcatcaat taacaggttg gcttttgaac ctgcttcatc taataaatca attgctttat 1349161 ccggcaggtg tctgtcctga atgtagcggg atgataaagt gacacatgct ttgattgctt 1349221 catcactgaa tgttacgcca tggtacgcct cgtatttgtc tttaatccct tgcagaatga 1349281 ggatagcctg ttcaattgaa ggctcctgca ccatgacagg ctgaaaacgt ctttccagcg 1349341 cggcatcttt ttcgatttga cgatattctt tcagtgttgt cgcgccaatg acttgcagtt 1349401 cgcctctggc tagggccggt ttgagaatgt tgccggcgtc cattgatcct tctgcagagc 1349461 ctgcgccgac gagaaggtga atttcatcaa tgaacagaat gacatttttt cgttccttca 1349521 gctcagtgat cagctgtttc attctctcct caaattggcc tctgatccct gtgtttgcaa 1349581 caagagatgc aacatcaagc aagtatagct ctttgttttt tagtttgttt ggaacatcac 1349641 cttcagcaat ttttaaagcg agcccttcag cgatggcagt tttccctaca cccggctcac 1349701 caataagaac cggattgttt ttgtttcggc ggtttagaat ttcgatcact cgcgccactt 1349761 catcatcacg gccgatgacg ggatcaatga gaccggcttt tgcaccgttt gtaatatttt 1349821 gagccagctc atcaagcaac cctttttttt cgctttgttt tgctgcgctc tgttctttcg 1349881 gctggaatgc ctgttcaaac ggaaatccga aagattgagg acccatactc attgaaggtt 1349941 tacgggtcag ttcgttatag caagtttcac aaagaaccat ctgtttatga acggaattta 1350001 tttgcatgtt aaggcgaatc gtcgcctcgt tttgatgaca atgttgacaa cgcatttgcc 1350061 aaaacctcct taataatttg atcatctttg accaatgaaa gtgaataaaa aggtctattg 1350121 ggtttgacct tctttgacta ttagtatacg gcaaacttaa cggcattcaa accaatatgc 1350181 tcaaagcaga ctgaatattt gactatcttt gaccaattga tttttaaaaa aggccggttt 1350241 gtttgaccaa ctttgattaa tagtatactc tgactatctt tgactttcaa gtcttatgca 1350301 caaaaatttt tgatttgtta caaagtaaaa catgttttct tcgtcttttc aaggaacttg 1350361 tctcataggt tataaaaagg catatatgga caaaactgcg gttcgttcgg agggaagaaa 1350421 tggaacaatc aaaagggtct gcaagtcagc ttgcttttgt gtatgtcggc acagtagtcg 1350481 gagctggatt tgcgactggg agggaaattg ttgagttttt tctgaagttc ggctggttcg 1350541 gttttttcgg cattctcgtc agcggcggaa tgtttacgtt actgggggcc aagctgatga 1350601 tcatttcaaa gcgaatcaat gccaagtcat atcaagaaat gaacatattt ttgttcgggg 1350661 cgacggctgg gcggattatc aatgtattta tgctgtttgt tctccttgga gttacatctg 1350721 ttatgctttc aggggcaggg gcgctttttg aggaacagct ggggatgtcc gctcagattg 1350781 ggatgctcat tacaatcggt ctgagtttaa ttgtgatgac tagaggagta aaaggcattt 1350841 tcggtgtcaa tgtgtttgtt gttcctcttt taatcatctt ttcaatgatt gtggtggccg 1350901 actcttttat attcagcgaa tcacgaaacg cagctcagtg ggtctggccg catcgctggg 1350961 attggctgtt atcagcagtt tcttacgggg ctttaaattt atcgcttgcc caagctgttt 1351021 tggttccgct ggcgaatgaa atgtcatcgg agaaagtgat aaaaaaaggc gctttaatcg 1351081 gaggcacgat gctgacgatt gtgctgtccg cgagttttct gtctttgtcg actcttccgg 1351141 atgtattttt gtatgatata ccgatggcgc aagtggttta tctctttgca cgatctgtcc 1351201 atttgattta tttactcatt attttcggag aagtgttcac atcagttatc ggtaatctat 1351261 atggattaga aaaacaagtg caaagctttc ttccagtgaa aagcaaatat atctttgcag 1351321 ccattatgat cacggcttat attacgagcc aaatagggta cggcaggctt atttcaacga 1351381 tttatccctt gtttggctat gtgagcctgg ccttcatagg cgctttgctt tgcaaaaaag 1351441 ctcctcggcg gcgcagttta taaatatata taatgaaacg aaccgtcact atagagcgat 1351501 aattgatcta ggaaccgggg actgactttt ttattgtcaa gaaaaacatc attatggtaa 1351561 gatagcagaa gtgaaaaaat tgaagaaaat ccgtgcgata tgcgggagag gttctagcta 1351621 caccctctat aaaaaactaa ggacgagctg tatccttgga tacggccttt tttatgtttt 1351681 tctagagcac cttccgaaaa aaggtgtttt tttgcgtgaa ttagctgtag cgatgtctct 1351741 cgccggcgtt tttattgcgg agaaggagag gaatcatgaa aaaagaaaaa gcaattgtcg 1351801 tatttagcgg cggtcaagac agcacaacat gcttactgtg ggccttaaaa gaattcgaag 1351861 aagtcgaaac ggtgactttt cattataatc agcgacattc gcaggaagtt gaagtggcaa 1351921 aatccattgc ggaaaagctt ggtgtgaaaa atcatttgct tgatatgtca cttttaaatc 1351981 agcttgcacc gaatgccctg actagaaatg atattgagat agaagtaaaa gacggcgaac 1352041 tgccatccac attcgttcca ggccgcaatt tggtattctt atcctttgcg tctatcctgg 1352101 cttaccaaat tggcgcgcgc cacattatta caggagtttg cgagacagac ttcagtggtt 1352161 atcctgactg ccgtgacgaa ttcgtgaaat cttgcaatgt cacggtaaat ctggcaatgg 1352221 agaagccgtt tgtgatccac acgcctctca tgtggctcaa taaggcggaa acgtggaagc 1352281 ttgcagatga gcttggcgcg ctggattttg tgaaaaacaa cacgctgaca tgctataacg 1352341 gcatcatcgc agacggctgc ggcgaatgtc cggcatgtca ccttcgttca aaaggttatg 1352401 aagaatatat ggtgatgaaa ggagagcgtg cataaattgt tatctcaaat ttatccgcag 1352461 gcccagcatc cttattcgtt tgaactgaat aaggacatgc atatctcagc cgctcatttt 1352521 atccctcggg aaagtgcggg agcgtgcagc agggttcacg ggcatacgta taccgtaaat 1352581 ataaccgttg ccggcgacga acttgacgat tcaggctttc ttgtcaattt cagcgtactc 1352641 aaaaaactgg tgcacggaaa ctatgatcac acgctattaa atgatcatga agatttttct 1352701 caggacgacc ggtattcgct gccgacaact gaagtcgtgg cgaaaacgat ttatgacaac 1352761 gtacaggctt atttagacac tttggagaat aagccgacct gtgtacaggt gtttgtccgt 1352821 gaaacaccga caagctactg tgtctaccgt ccgaaaaagg gtggtttgaa tggctaaagg 1352881 aattcctgta ttagaaattt tcggcccgac gattcaagga gaaggcatgg tgatcggaca 1352941 gaaaacgatg ttcgtccgga cagccggctg cgattattcc tgcagctggt gtgactccgc 1353001 tttcacttgg gacgggtctg ctaaaaaaga tattcgctgg atgacggcgg aggagatttt 1353061 tgcggagctt aaggacattg ggggagatgc gttttctcat gtgacgatct caggcggcaa 1353121 cccggctctg ttaaaacagc tggatgcttt tattgaactg ctgaaggaaa ataacatccg 1353181 tgcagcgctt gaaactcaag ggaccgttta tcaggattgg tttacgctga ttgatgacct 1353241 gacaatttct ccaaaaccgc caagctcaaa aatggtaacg aactttcaaa agcttgacca 1353301 cattttaact tcacttcaag agaatgatag acagcatgct gtcagcttga aggttgtcat 1353361 ctttaatgat gaagatctgg aatttgccaa aactgtgcac aagcggtatc cgggaatccc 1353421 gttttattta caagtcggaa atgatgacgt gcatacgaca gatgatcagt cactgattgc 1353481 acatttgctt ggaaaatatg aagcgcttgt tgataaggta gctgtcgatg cggagctgaa 1353541 tctcgtcaga gtgctcccgc agctgcacac cctgttatgg ggcaacaaac gcggagtata 1353601 atagaaagga agatgaacat gacgacaaga aaagaatcag aattagaagg tgtaacattg 1353661 ctaggcaatc aaggtacaaa ttatttgttc gaatatgcac cggacgtgct ggaatccttc 1353721 cctaataaac atgtaaaccg tgattacttt gtaaaattca attgcccgga attcacatct 1353781 ttatgtccta aaacaggcca gcctgacttt gcgacaatct acatcagcta cattcctgat 1353841 gaaaaaatgg ttgaaagcaa atcattaaag ctgtatctat tcagcttcag aaaccatggt 1353901 gacttccacg aggactgcat gaatatcatc atgaacgact tgattgaatt aatggacccg 1353961 cgctacattg aagtatgggg caaattcacg ccaagaggcg gaatttccat tgatccgtac 1354021 acaaactacg gaaagcctgg cacgaagtat gagaaaatgg ccgaataccg tatgatgaac 1354081 catgatttgt atccggagac aattgataat cgttaattat tccgttgtgt gatacggagt 1354141 gtaaaaggaa gtggagtcac agtaaaatcc gaacattcag cgttaatttt cagcggaaat 1354201 gtgacctggt cacagcgaag tgtgacccgc actaagctca ataaaagtgg gaaaagtcac 1354261 acctgaaaat ggctctactc atgggaattg tattaaaaag tgtgacctga ggtgcaacct 1354321 gaactgtgac ttttatgcag tgaaaaattg atagtacaga agcagattaa ggcgtacaat 1354381 ttgtacgtct tttctttttt atccgaaaga aaaaatgcct atctagagat cataggcatt 1354441 aaatattatt atcaatatct tcatttattt tttggctaag tttctgaacc ttctctttaa 1354501 catttgaaac agctcttttt tgaatttcat caattctcct gaatatagtc gatgacactt 1354561 cttattagaa cttcactttc aaaattgaat atctcattta tttctgactg ttcttcatct 1354621 gttaggtgat ggtattgaag ttgtttagca tttacttcag cagctacatc aatcctaact 1354681 tagttgttct ggttgtacaa tttcatattc accttctgca tactcttgct ccgcataata 1354741 gcctccccat tgacagagct cctgcaagat aggtttaaga gattctccaa gttcagtgga 1354801 tgaatattca accttcggcg gtacttgatt atacatcttt ctgctcacaa gtccactggc 1354861 ttcaagctct ctaagtgttt gaatcagcat tttctgagtt atatttggga taatgcgctt 1354921 taattcactc gttctctttg gtccattcat taaaaagtat aatacaaggc ctttccattt 1354981 tccgccaata acttcctttg tcacttcaaa cccacagcta aattttttca tgtctaaagc 1355041 tctccattcc acatttatta ctttttagtt actatatcac aaaaaagtgg gtacttccga 1355101 taatgtgctt actgaaggat actatatctt gtaagttgtt cttcaagtac ttaaaggtac 1355161 tagacataaa ataaaattaa ttctaaagga gtgttaagta tgggtaaatt tgaaggtaaa 1355221 atagcgcttg taacgggtgg aacaagtggg attggtcttg ctacagcaca aaaatttgta 1355281 aacgaaggtg catatgttta tattacggga cgtagacaaa acgaacttga taaagctgtt 1355341 aaccaaattg gcaagaacgt aaccggtgtt caaggtgata tttctaagct tgaagactta 1355401 gacaaactat atgacattat aaagcaggaa aaaggtaagt tggacattct ttttgctaat 1355461 gcaggcatcg gcaacttcct tccattaggt gaaattactg aagagcaggt tgatagaacg 1355521 ttcgacatta acgttaaagg aaccatcttt actgttcaaa aagcgttatc actattcccg 1355581 gacaaagtag gttctattat tgtaacgggc tctactgctg gatcaattgg caacccagcg 1355641 tttagtgtat atggagcatc taaagcagca ttaagagcac tagttcgcaa ctggattctt 1355701 gacctaaaag gtactgaaat ccgtgtaaat gtggttagtc caggaggtat tcttacacct 1355761 gcctacgatg agctttttgg tgatgcactt gaagaggtac tggaaaatag cagaaatact 1355821 gttccagctg gaaaagttgg gacacctgaa gaagtagcaa acgctgtatc tttccttgct 1355881 tcagacgaaa gcagttactt gacgggtgtt gaattgttcg tagatggcgg gctagcacag 1355941 gtataatttc actgcgcaga gattacaaat agtccccaaa aaaggttaat ggggatttac 1356001 ttgaagaagt cgtataaaaa agtcgttttc cttaaaggac agggaattcg acttttttat 1356061 atttgaattt gattaacgtt gtaaattcgc attttcctgg ggctactact aaatgacctg 1356121 taaaaaagat tacactgtga ataaatgtac ttaaagtaac gggggctctt gacttttaat 1356181 aaaaaataat atccctgtcc ttgtattcta atacttttaa aaatatttaa aggaatcctt 1356241 atgtcctgaa taaccacata ggaaaatatg ttgtaggttg ctttcttttt ttgtggggca 1356301 tcccacacaa gctatctcgt gatctcacac ctgaacgttt tttatagact agtaccgcga 1356361 caagttatat tacatataca taccaataaa gtagacatta aaaagtgaaa gagaggatgg 1356421 aaatgtgtga aaattctttt ccttgagagt catcccatgt ggctctatgg tttaccgaat 1356481 gggtttaggg aagcaggaca taccgtaatg atttccggtc ctgtaagtcg ggaaaatata 1356541 actgaaatga tagacgaatt taaaccagat ttaatagtat ctatgggatg gacaccagag 1356601 cattcaaggg aaaagcaggc ctggattcgc aacgctacta aaaaggtgaa tatccctctc 1356661 gtttattggg caactgaaga cccgctgcac actcaaaact ttactatccc gttaattaaa 1356721 aagatgaaac cggattttgt tttcacggtc acgccttctc tgtgtaaaac ttatgaaagc 1356781 atggggatta aagcagctca cttagacttt gcatttcacg aaagtataca tcaccagatt 1356841 aaaccattag cgaaatacag ttgtgatata gcagtggtgg ctaatgctta ccctaatttt 1356901 cttgaagaac atccggaagt gttccgttcg tcctctttaa aaacgcttat tcgtcctctt 1356961 atacggaagg gtattcgcat tgatttttgg gggagaaact gggaaaaaat gagtaaatat 1357021 ataggaagag aaattccccg caattggatc catggatacc ttgattatac tgaagcatat 1357081 aaagtttaca gttcagcaaa aatcattatc ggtttgcaaa actgtgaaag ccaacttaca 1357141 caacgcacct atgagattct tggttccggg gggtttttat tgacatcgga tacaccagca 1357201 gttcgaggta aattcaaacc tggccgcgat ctcatcgttt cttcctcccc aaaagaaaca 1357261 ttggaaaagg ttaaatacta tttaaatcat gatagcgaga gaaaaaagat tcagataaac 1357321 ggtaaaaagg ctgtaaagaa tgattcctat cggcatagag ccgagagaat gcttgaggtg 1357381 ctaaaaagca gaggaatcat aagaaactta ggggaaacca ttcattatgt agatgttctc 1357441 aaagaaaaat acgtgatcca tcatgttact cccggtgaaa cattatcaat aattgccagt 1357501 aagtataatg tttccctgca gcaactcatg gagcttaatc atttcaaatc agatcaaata 1357561 tatgctggac aaatcattaa gattagagag aaactgttta gaaatattaa taacaaatta 1357621 ttctaaagga gagtaatatg aatgaagggg aaaataccta aaataagaaa tcaagcgaat 1357681 aaagtaaaaa gaacgcctcg ttatatggaa tttcccgtga catacgaagt atatcatgtg 1357741 gaatccggcg atacattatg gacgattgcc aaatcctttg aaattccggt acaacaactt 1357801 atgaatctta ataagctttc ttcagataga atttatcctg gacaaattat aaagataaga 1357861 gaaagataat ctttgaggtt tcggaagcga atcaaattga aatgacaatc ctcatttttt 1357921 tatttgtggg gaacttgata tttttgggga tgaaggggtt atgagatgtt tcaaatgagc 1357981 tattactatt ctggattagg atgggacttt attcaacacg ttgatcaaac gaacggagta 1358041 ttaaatgttg tgtctcctga ttttttctat atcagaaaag atggatcatt acttctccgt 1358101 tcagctaatc ccgatgtgat taaagctctt catagaagaa aattaaaagt agttcctttt 1358161 ctaagcaatc attgggatca ggatttggga cgatttgcat taatgaaccg agttctttta 1358221 gctaaacaaa tttctcatgc aatagaagaa ctggatttgg atggagttaa tatcgatata 1358281 gaaaacctta cagaaaaaga tcggaatcta tttacagatt ttattagatt agtaaggaaa 1358341 agtattccta gacataaaga agtatcagtt gcagtggcgg caaatccttt tggctggacg 1358401 aagggctggc acggatcata tgattacgag tatttagcta aatatgcaga ttatcttatg 1358461 gttatggcct atgatgaaag ccgccttgct gggcctactg caagtgtagg atgggtggaa 1358521 aagtccattc aatatgttct gacccaaaaa atctctcctc aaaaactagt tttaggattg 1358581 ccattctatg gccgctgctg gatggaaggc caatctgcct ctcaagccat tcccctttac 1358641 cttgttgtta gtaaaaaggc atagcgggac aattattttt gacaccaaga gtcaatctcc 1358701 aaaagctatt tttactgtca atcacgataa aaaggggccg ttgccttcgg gaacatatac 1358761 attatggttt gaaaatgaac agtcactcag agcaaaaata aaactcgctc aaaaatataa 1358821 tctgaaaggt cttggcagct ggagtcttgg acaagaagat gcgtcagtct ggaatacagt 1358881 gtttaaaaat atataatgat ttatagttca gaacaaaatt cgaagataat tgcaatgaat 1358941 ctctaaatgg acatactgaa aggagtttat tacgagtgcg ggtaaaacag tgagggcatt 1359001 ccataggccc ttctcccaaa atgttctaca cgaggcatta cattgggctt gaaatacaca 1359061 ttcaaactta tgttatagta cgcattttac ggatgtgttg aatttattct gcttccatga 1359121 tttaatcata cacatgctac ttgatagcag ggttatcgca tttcattcag aattgttcag 1359181 gatcgatatg gaagcgcacg actaactaga actttaaaag catacactca tatacttcct 1359241 gaatggatgc tggtttatct aaaaaacatg atgagaattg attgtacgca tggtgaagca 1359301 tgacttgttg ataatcgacc atatggtttc tccttagaaa tgagggggtt tttacataaa 1359361 aaagacgagc gaatccgggg ggaattccac tcgccgcttt ctaatgaaaa gacgggatgc 1359421 tggatggcag ctcgtctgtt ttattataat ttaacgaacg tatgtttgta aaggtgtctt 1359481 ttcgaatgaa ttggttcata taaccgttaa gaacagattc attgtaaaca ttcgctaagg 1359541 tatgctaaga tgcatggact ataaaggagt gatatgaagt gaagacattg cggttaaaca 1359601 atgtaacgtt agaaatggct gcatatcaag aggagagcga gccgaagcga aaaattgcat 1359661 ttaccttaaa cgttacgagt gagacttacc atgatatcgc tgtcctgttg tatgaaaaaa 1359721 cgtttaatgt cgaggttccg gaacgcgatc ttgccttccg gggggaaatg acaaattatt 1359781 caacatcatt gaccaacctg tacgaaccag gggccgtcag cgagttctat atagaaataa 1359841 cggaaataga caaaaacgcc gattcatgat cggtgttttt tatgtaaaaa agctgccggc 1359901 cggcagcttt tgagaaagcg aatttcatat gtaaggtgtt aaattgtccg tcttgcagtt 1359961 ttttgaataa atgtggaaat aaggaggttt taataggagt ctctgatgat cttataattt 1360021 ttatgattaa caactgtcaa tgaatctaac tcaagatccc gatagttatc catgatcgtc 1360081 acatcaacga taacagaatt ctcatttact ttttcaacaa caccggttaa tccgttttta 1360141 aattcaatga cattcccaac cttagcgatt ttcacaagct tcctctcctt taaacataat 1360201 aatgcctttt gaaagtattt tgcagtattt tcattgagaa gtaaagcgat aaggagtttt 1360261 atctccctta tgaattgttc tgtcgctata aagatgatat attgattttc gtcaatagaa 1360321 agaaaagggg ggaatttttg ttgcgtcccg aagaaataac agaaatgatt gaacagctgc 1360381 gcaccggcgc cataaacgaa ctgagagtcc agaaagagca ttttcttgat ttcagggccg 1360441 tgttatctaa acaagatgat tttaaacatt tccgaggaat tgcccagcaa ggcggagatg 1360501 ttatctttca atacttagaa cagccaagaa gctgaaggtt tctcatacgt gagaagcctt 1360561 tttatcatat atgacagaac acaagccttt tattacagct gtctgtaaca ggtgtaaata 1360621 aaatgtaaag taccaaagat ggataaacat gttttaattt aacaatattt atagaatttc 1360681 agactgtttt tttgccatta agcagtgagt catcctcttt attccatcct gatacctcct 1360741 tgggagagtt ggaaaatctt tttccgtgaa aatgaatgga tctcttgtta aggttatgaa 1360801 gtgttttttg gagcacttta aggaggaaac tgtatgacaa cgaaattcac tgctctggct 1360861 gtttttcttc tttgtttcat gcctgcagcc aaaattgagc atacacaagc ttcactactg 1360921 agcgcaaaga agacaaaaca tgaagaagcg aaatggctta cacatataga tcgaaatacg 1360981 aatgaatctt tcccttcact gtctgctgat aaagacaaga aaataaaacc gattaagcta 1361041 tcagcacaca ctgaaaagaa agagaaagat aaaccggaca aaacaaatga tgagaaagaa 1361101 acatatacac agtctgaaaa agagttgctg tcccgtctcg ttcacgcaga ggccaaagga 1361161 gaatcatata aaggcaaggt cgctgtagca agcgttgtac tgaacaggac ggagaaaaaa 1361221 ggttttcctg atacgataag aggagttatt tatcagaaaa acgcctttga accggtcgca 1361281 aacgggagca ttaaccaaaa gcctgataaa gaatcgattg aagctgccga agaagcgctg 1361341 tcctcaaaaa atagagaaac agatgccata ttcttttata atccgaaaac agcgtcagat 1361401 aattggattc gttcaagaaa aatcgtagaa aaaatcggca gacacgtttt tgccgtctaa 1361461 gcatagaaga gacaatttgt ctcagctgtg ctttttttca tataaagagt aaaaataaaa 1361521 taatttttga acttgtctca tatgatgttg gtagtacaag agacaaggag agacatcatg 1361581 aatcgatttg tgaaagggat cattctttta tccattgccg cctttttcgc tgaatgcctt 1361641 gaatttgtcg tcaatatgat tttggcgcgg gagcttggcg agcatgggat ggggctttac 1361701 atgagtattt tgcccacgat ctttttaatt attgtcatcg cgagcctgga actgccgata 1361761 tccatttcta aattcattgc cgagtcaaat cctaagcttc atgaaagcat gctgaggcac 1361821 gctttcagaa tgacagccat ttttactgct ttttctactg ccgccgctag tattgcgctt 1361881 ccgtttattc cggtatttga tacataccac ccgtttatta aagggattgt catcggctta 1361941 attcctgttg tcgcctttac ttcaatcgcc aggggctact ttatgggtgt gcagaaaatg 1362001 gggaagatcg caattgccaa tgtgctgaaa aaaatcatcc agctcttgtg cttattcctc 1362061 ttttttcaat ggtactcatt tgaattggac atggctgtgc tgatttcctt gtttgttcta 1362121 gtcgtgagtg atgtggtcgt gcttgtttat ttatattcac aatttatcat ggcaaggcgg 1362181 gcgttatccg gccagcagca cattcatttg cgcggaaagg atgtaaggaa aagactgctt 1362241 gctgtttcaa ttcctacaac aggactgcgt atttttcatg cggttgtcaa tgcaattgaa 1362301 ccctttttag taaaaggagc tcttttggct gcgggcgttg ccgggacagc ggcgatcgat 1362361 caatacggaa tgctggcagg agtggctgtg acgatagggt cgttccctgc ttttattgcc 1362421 cattcgttaa tggtcgtcat gataccgagt atttcggaag cttatgcact ttctcagtat 1362481 gacatcgtgt taaaaaggct gaagcagtcg attttcatta cattaggtta cggtatacct 1362541 gccgtctggg tcatgttcca gtttgcggga cctctcacgc atttgttttt tcactctcct 1362601 gaagcgcagt attacttgca gctgttgtgg ccttactttc tctttcatct gtttgtcatg 1362661 ccgctgcagg cgtgcttaat cgggatgggt tttgtgaaag aggcttttta tcacaatgta 1362721 tggagccata tcgttgcgct aagtatgatg tatgtactgg gatcaatgga gaatctgcaa 1362781 atgctcggga ttatccttgg aatgaacact ggcatgattc ttttgacgag cctgcactat 1362841 gccacgatct gcaaagcatt gaaggtatct gtatttctta cgggagggac cagaacgccg 1362901 cgaattgaag gatgataaag gaacagcagg ggcaagctaa ttgaaaagca tgaaaggaag 1362961 attccatgtt gacgaagcgc ttgcttacta tatacattat gttattaggg ttgattgcat 1363021 ggtttccagg tgcggcacaa gctgaggaaa aacagcctgc tgttcccgct gtttttctta 1363081 tgaaaacgat agaaggggag gacatctcga ttccgaataa agggcaaaaa acaattctcc 1363141 atttttggac gtcatggtgc ccgccctgca aaaaggagct tccacagttt caatcgtttt 1363201 atgatgccca tccatccgac agtgtaaagc tggtaacggt gaatttagtg aattcggaac 1363261 aaaatcagca agtcgttgaa gactttatta aagcaaacaa gctgacgttt ccgattgtcc 1363321 ttgactcaaa aggggaattg atgaaggagt atcatatcat cacgatccca acatcatttt 1363381 tgctgaatga aaagggagaa attgaaaaaa caaaaattgg cccgatgaca gcggaacaac 1363441 tgaaggaatg gacggaagaa tagctgagag catagactct cagctttttt catatagaga 1363501 agaagtgaat aaacattaat gataattatt atcaaaaaga aattaaaata attataattg 1363561 aaattctctt cgtgcgtgct ataataaagg aagacatcaa gaaataactg acgataaagc 1363621 tgccttttgg gcagcgattt tgtttttata agagaaatga agatgattta cgttctcaat 1363681 tagagaggag aattcgatat gaatgaacaa gttatcgttc aacgcgaccc gcatgagcca 1363741 ttgaaaacag acaagaggga aaaaaactgg gcacagcacg cggagcttat tgcagcactt 1363801 gtatcaggcg ctcttatttt ggcaggctgg ctcttatccg gatatcaggt attatccata 1363861 atacttttct tgctggcttt tgtgatcggc ggatttgcta aagcgaagga aggaatcgaa 1363921 gaaacactcg aatccaaaac gctgaatgta gaacttttaa tgattttcgc tgccattggt 1363981 tccgccttga tcggatactg ggcagagggt gctattttaa tatttatttt ttccttaagc 1364041 ggagctttag aaacatacac gatgaataaa agcagcagag atttaacgtc tttaatgcag 1364101 cttgagcctg aagaagcgac attgatggtc aatggtgaaa ccaaaagagt tccggtttca 1364161 gacttgcagg ccggtgatat gattgtgatc aaacctggag aacgcgtagc ggcagacggt 1364221 atcattgaat cgggctcgac aagtcttgac gagtcggctt taacaggtga atcaatgcct 1364281 gtagaaaaaa acacaggcga cactgtattc acaggaacgg tgaatcgcaa tggctccttg 1364341 acagtccgtg tcacgaaagc aaatgaagat tcgttattca gaaaaattat caaactggtt 1364401 gaatcagcgc aaaatagtgt ttcacccgcg caggctttca tcgaacgatt tgaaaatgct 1364461 tatgtgaaag gtgtgctaat tgcggtggcg ctccttttat tcgtcccgca ctttgcgctg 1364521 ggctggagct ggagtgaaac cttctaccgc gcaatggtgt ttatggttgt cgcgtcacct 1364581 tgtgcgcttg tcgcctctat tatgccggcg gcgctgtccc tgatttcaaa tggcgcccgc 1364641 aacggtatgc ttgtgaaagg aagcgtcttt cttgaacagc tgggctcagt gcaaatgatc 1364701 gcctttgata aaaccggaac tgtaacaaaa ggccagcctg ccgtagagac gatcagaata 1364761 gcagaaggat tcagtgaagc ggaagttctt gaggctgtct atgccatcga aacgcaatca 1364821 agccatccgc tcgcccaagc cataacggcg tacgctgaaa gccgcggcgt gaatcagtcc 1364881 ggctacatat ctatagaaga aacctcaggg tttggcgtta tggcagaagt gtcgggtgcg 1364941 aaatggaagg tcggtaaagc aggttttatc ggcgaggaaa tggcagcaca atttatgaaa 1365001 caaacagcat cagatgtcat tcaaagcggt catacaattg tatttgtgaa aaaggatgat 1365061 caaatagcag gctgtatcgc actgaaggac caaatcaggc ctgaagcaaa agaggtcatg 1365121 gaagaactga accgacttgg gattaaaacg gccatgctga caggagatca cgaagacacg 1365181 gctcaagcga ttgccaagga agccggcatg acaactgtcg tggcagaatg cctgcctgac 1365241 caaaaagtga atgaaatcaa acggttaaaa gaagaattcg gaacgattgc aatggtgggt 1365301 gacggaatca atgatgcgcc ggcactcaaa gcagcggatg tcggcattgc gatgggcggc 1365361 ggaacagatg tagcacttga gaccgctgat atggtcctca tgaaaaacga tttgaaaaag 1365421 ctcgtaaaca tgtgccgctt gtctcggaaa atgaacagga tcatcaaaca aaatatcgtg 1365481 ttttctctag ctgtaatctg cctgctgatt tgtgcaaact ttttgcaggc gatggaattg 1365541 ccatttggcg tgattggtca tgagggcagc acgattttag tcatactaaa cggtttaaga 1365601 ctcctaaaat aaaaccagca gcctaatcag gctgctggct ttttatgtat caagctttcc 1365661 cttcattttt gtctttatca gatcttttca taactaggat gagagcgagg gtgcagcaaa 1365721 ggaaacccgc tgcacagcct atgatagagc tgtaataata aaagcccacc atcttcatcc 1365781 cgataaaagg agcggaaatt cccaaaaccg ttaagagcat aactgctttt cgtctgaaaa 1365841 aattcatcag caaacggaac aacccccctg cgattgaacg ttactgtcag tatacaggaa 1365901 gaggagcagg aaataaaatg cattagaaaa tgaaggcgtc gtgaaaggca aacaccggta 1365961 aaacctgtta caatggaaga cagaacaatg cattgcaaat ggcagggagg aacaagaagt 1366021 gaatagaata caacgcgtct cttcatggct gaaggaagcg gggcatactg ccgcatttat 1366081 tcatacgaaa gaaaatgttt tttacttaac cggtttttac acagagccgc atgaaagatt 1366141 aatggggtta tttatttttc aagaagagga gcctttcttt gtttgtccag gaatggaagc 1366201 aggacaggcc cgcaacgcag gctggaatca tgaaatcatt ggctatgcgg atcacgaaaa 1366261 tccgtgggag ctgatagaga aggctttgaa aaagcgaaat atcagcatac atatgcttgc 1366321 ggtagaaaag gattcaatct cgctgtcacg tgcagaacag ctgaagcatg cgacgggcgg 1366381 ggctcaattt gtttcagcag aagaaacact caatcaattt cgcctgatta aagatgacaa 1366441 tgagattcgt ttgctgaaag aggcggcaaa gcttgcagat tacggtgttg aagtcggcac 1366501 agccgctttg cgtgaaggca tcagtgaagt ggaagtgctc gctcaaattg agtatgagct 1366561 gaagaaaaaa ggaattcagg gcatgtcttt ctctacaatg gttttattcg gagaaaaatc 1366621 tggccagcct catggaaatc ctggtacagc cacgttgaag aaaggtgatt ttgttttatt 1366681 tgatctcggt gttattcttg atggctattg ctctgatatt acaagaacgt ttgcatacaa 1366741 aaccatcaat ccgaagcagg aggccattta cgagactgtg cttcaagcgg aaaaagccgc 1366801 gattgaggca agcaaacccg gtgtgagaat cggagatctg gatttaactg cccgcggaat 1366861 cattgaaaaa gcgggatatg gtgattattt tcctcaccgg cttgggcatg gactcggaat 1366921 ttcagtccat gagtatccat caatgagcca ggccaacgat acactgctgc aggaaggcat 1366981 ggtctacacg atcgaaccgg ggatttatgt gccagagatc ggcggcgtac gcattgagga 1367041 tgacgttcac gtaacaaagg acggagcagt tgctctgacc caatatccaa aggatttgat 1367101 catactgtaa tagaaataaa aaaggacttt gttctcgaca tcgtcctttt ttatctgcat 1367161 taaataaaaa aatcatcaaa tgttcgaaag ggtttaattt catgtttttg gttgagaggt 1367221 tttacagcaa gacagctgcc accgagaaca gtgagacata acccaattaa aatgaagaaa 1367281 cccatgtgat cttctccttt cagctaaaaa cacaaaaaga tatctggtac gtccatatca 1367341 tattgtatga aacgcattcc agatcaaggg gatttagaaa gaagggaatc tatggctaat 1367401 attaaagaca ttgcagagaa agccggtgtc tctgttacaa cggtttcccg agtcataaac 1367461 aatcatccat acgtcagtga agacaaacga aaaagagtgt ttgaggcaat ggaatcattg 1367521 gagtacacga gaaatattca cgctgtacat ttgtcgaaag gattttcaaa catgattggt 1367581 gttgtcttgc cgacggttaa tctgccatat tttgcagagc tgattgcagg aatagccgac 1367641 gcagccgcgg aatccggggt tcacctctct ttattccaaa caaactatga agtacaaaaa 1367701 gaaatctttg cgctgtccca attaaagcag cgccaggttg acggcctgat tttttgctca 1367761 aaggcgcttg ctgatgagaa actcatggaa tgggagggcc cgattttgct ttgccagaat 1367821 tcagataatg cccgcttccc aaccatcagc attcctcacc aagaagcatt tcggaacggc 1367881 ttggactatt taattgccaa agggcacaaa aaaatagcca tctgtttggc aagaaaaaaa 1367941 ggcatgaaca gccattttcg aatcaaagcc tacaaagagg cattggaaga gatcggcgag 1368001 gcatttcgtg aagactgggt aattgagaaa gcgattacaa tcaatgatgg gaaggcgctt 1368061 tttcataaat ggaatacgtg gaaggaaaag ccgacggcta tttttgttgc caatgaccaa 1368121 gtctcagcag ggctttttct tgaagcaaag aaccagcggg tgtcagtacc ggatgagctt 1368181 gcaatcttaa gcgttgataa ccacgaaatc agccaagcgc ttggaatcac aacgatcgat 1368241 attcagacaa gggaaatggg aaagcaggca tttgccatat tggaaaaaag aattcaagga 1368301 cagccgattg aaaggaaagt tctggattac cgtctcatcg aaagatcgac tgtttagtga 1368361 atgcattgaa aaaaggtttg acgtgcattc tgttcgttat gtacgatatg aggtattgaa 1368421 tgacaaagga gctgaggatc gtgaatgggt ccttcacagt gaaaaaggta ctgaataata 1368481 acgtattaat tgcttctcat cataaataca gcgaagtcgt tttaatcgga aaaggtattg 1368541 gtttcggaaa aaaacaagat gatgtcattg aagataaagg ctacgataaa atgttcattt 1368601 taaaagacga gaaggaacaa aagcagttta aaaagctcct tgactatgtt gatgaaaagc 1368661 tcgttgatat ttcaaacgat gtcatctatc acataagcaa taggacgaat cactcattaa 1368721 atgaacatat tcacattgcg ttgacagacc atatcgcatt tgcgatcaaa aggcagcagc 1368781 agggatttga tatgaaaaat ccatttctaa tggagactca gtcactatat cctgaggagt 1368841 accaaattgc caaagaagtc atagatatga tcaatgaaaa agcgggactc tgccttccgg 1368901 aaggggagat tggttttatc gctctgcata tccattcagc gttgacaaac cgtccgctgt 1368961 ccgaggtcaa tcagcactct cagctcatgg cgcagcttgt cgaggtgatt gaagactcat 1369021 ttcaaatgaa agtaaataag gaaagtgtca actatttgcg gctgatcagg catatcagat 1369081 ttacaataga aagaattaaa aaagaagaac cgactaaaga accagaaaaa ttaatgttgt 1369141 tattgaaaaa tgaatatccg ctatgctaca atacagcttg gaaattgatt aaaatcttgc 1369201 agcaaacatt gaagaaacca gttcatgagg cggaagcggt ttatctgacg cttcatctgt 1369261 accgattaac caataaaatt tcataaattc agtttatcct tataacgtgt tactgattcg 1369321 atcaggcatg agtgattgag ggaaaaaaac gggaagttca ttctcgttct tttgcgcacc 1369381 caattttgct catgcctttt tgttgtgtaa aagggcaaat gtaaacggtt aaactggaag 1369441 acttacgcct gtgaattcgt tgtcatgatt tttagctgta aggtcagact agtaaaaaga 1369501 ggaggtcaat tcttatgttt aaagcattat tcggcgttct tcaaaaaatt gggcgtgcgc 1369561 ttatgcttcc agttgcgatc cttccggctg cgggtatttt gcttgcgatc gggaatgcga 1369621 tgcaaaataa ggacatgatt caggtcctgc atttcttgag caatgacaat gttcagcttg 1369681 tagcaggtgt gatggaaagt gctgggcaga ttgttttcga taaccttccg cttcttttcg 1369741 cagtaggtgt agccatcggg cttgccaatg gtgatggagt tgcagggatt gcagcaatta 1369801 tcggttatct tgtaatgaat gtatccatga gtgcggttct tcttgcaaac ggaaccattc 1369861 cttcggattc agttgaaaga gccaagttct ttacggaaaa ccatcctgca tatgtaaaca 1369921 tgcttggtat acctaccttg gcgacagggg tgttcggcgg tattatcgtc ggtgtgttag 1369981 ctgcattatt gtttaacaga ttttacacaa ttgaactgcc gcaatacctt ggtttctttg 1370041 cgggtaaacg tttcgttcca attgttacgt caatttctgc actgattctg ggtcttatta 1370101 tgttagtgat ctggcctcca atccagcatg gattgaatgc cttttcaaca ggattagtgg 1370161 aagcgaatcc aacccttgct gcatttatct tcggggtgat tgaacgttcg cttatcccat 1370221 tcggattgca ccatattttc tattcaccgt tctggtatga attcttcagc tataagagtg 1370281 cagcaggaga aatcatccgc ggggatcagc gtatctttat ggcgcagatt aaagacggcg 1370341 tacagttaac ggcaggtacg ttcatgacag gtaaatatcc atttatgatg ttcggtctgc 1370401 ctgctgcggc gcttgccatt tatcatgaag caaaaccgca aaacaaaaaa ctcgttgcag 1370461 gtattatggg ttcagcggcc ttgacatctt tcttaacggg gatcacagag ccattggaat 1370521 tttctttctt attcgttgct ccagtcctgt ttgcgattca ctgtttgttt gcgggacttt 1370581 cattcatggt catgcagctg ttgaatgtta agattggtat gacattctcc ggcggtttaa 1370641 ttgactactt cctattcggt attttaccaa accggacggc atggtggctt gtcatccctg 1370701 tcggcttagg gttagcggtc atttactact ttggattccg atttgccatc cgcaaattta 1370761 atctgaaaac acctggacgc gaggatgctg cggaagaaac agcagcacct gggaaaacag 1370821 gtgaagcagg agatcttcct tatgagattc tgcaggcaat gggtgaccag gaaaacatca 1370881 aacaccttga tgcttgtatc actcgtctgc gtgtgactgt aaacgatcag aaaaaggttg 1370941 ataaagaccg tctgaaacag cttggcgctt ccggagtgct ggaagtcggc aacaacattc 1371001 aggctatttt cggaccgcgt tctgacgggt taaaaacaca aatgcaagac attattgcgg 1371061 gacgcaagcc tagacctgag ccgaaaacat ctgctcaaga ggaagtaggc cagcaggttg 1371121 aggaagtgat tgcagaaccg ctgcaaaatg aaatcggcga ggaagttttc gtttctccga 1371181 ttaccgggga aattcaccca attacggatg ttcctgacca agtcttctca gggaaaatga 1371241 tgggtgacgg ttttgcgatt ctcccttctg aaggaattgt cgtatcaccg gttcgcggaa 1371301 aaattctcaa tgtgttcccg acaaaacatg cgatcggcct gcaatccgac ggcggaagag 1371361 aaattttaat ccactttggt attgataccg tcagcctgaa gggcgaagga tttacgtctt 1371421 tcgtatcaga aggagaccgc gttgagcctg gacaaaaact tcttgaagtt gatctggatg 1371481 cagtcaaacc gaatgtacca tctctcatga caccgattgt atttacaaac cttgctgaag 1371541 gagaaacagt cagcattaaa gcaagcggtt cagtcaacag agaacaagaa gatattgtga 1371601 agattgaaaa ataagggtgt tagtacgccg tgcttgtcag atgacaagta cggttgtatg 1371661 atataatatt gtgaagtaat aaagctttaa gttaaaagga gaatgataaa aatggcacaa 1371721 aaaacattta aagtaactgc agattctgga atccatgctc gtcctgcgac agttcttgta 1371781 caaactgcta gcaaatacga cgctgacgtt aatttagaat ataacggcaa aacagttaac 1371841 cttaaatcta ttatgggtgt tatgtcttta ggtatcgcta aaggcgctga gatcacaatc 1371901 tctgcttccg gagctgacga aaacgatgct cttaacgctt tagaagaaac aatgaaaagc 1371961 gaaggactcg gcgagtaatg caagaattaa aagggattgg tgcttcagcc ggcatcgcga 1372021 ttgcaaaagc gtaccggctt gaagagccag atttaacggt tgaaaagaaa aacatctctg 1372081 attctgaagc ggaagtaagc cgttttgatg aagcgattgc acgttcaaaa gaagagctcg 1372141 aaaaaatcaa agagcacgct ttgaaagaac tgggtcagga taaagctgat attttttctg 1372201 ctcacctttt agttctcagt gaccctgagc ttctgaaccc tgtgaaagaa aaaatcagca 1372261 ctgattcagt gaacgctgaa ttcgctttaa aagaaacgtc ttctatgttc gttactatgt 1372321 ttgaatctat ggacaacgaa tatatgaaag agcgtgcggc agatatccgc gatgtaacaa 1372381 aacgcgtaac cggccacctg cttggcgtcg aaattccaaa cccaagcatg atctcagaag 1372441 aggttattat tgtagctgaa gacttaacac cgtctgacac agctcaatta aaccgtgagt 1372501 tcgtaaaagg attcactact gatatcggcg gacgcacatc tcactctgcc atcatggcac 1372561 gttctcttga gattccagca gttgttggaa cgaaagctgc tacaggcacg atccaaaacg 1372621 gcgtgactgt tatcgttgac ggtatcaatg gcgatgtcat tattgaccca tctgcggaaa 1372681 ctgtaaaaga gtatgaagaa aaacataatg cttatttggc tcaaaaagct gagtgggcga 1372741 agcttgtcaa tgaaccgact gtctcaaaag acggacatca tgtagagctt gcagcgaaca 1372801 tcggtactcc tgatgatgta aaaggtgttc ttgaaaacgg cggagaagca gttggccttt 1372861 accgtacaga attcctttac atgggaagag atcagctgcc tacagaagat gagcagtttg 1372921 atgcttacaa aacggttctt gagcgtatgg aaggaaaatc agtcgtcgtg cggacacttg 1372981 atatcggcgg agacaaagag cttccttacc tgcagcttcc taaagaaatg aacccgttcc 1373041 tgggatatag agcgattcgt ctttgccttg aagagcaaga aatcttcaga acacagcttc 1373101 gcgcgctgct tcgtgcaagt acatacggaa acttgaaaat catgttccct atgattgcga 1373161 cagttaacga attcaaagaa gcaaaagcga tccttcttga agagaaagaa aagctcgtaa 1373221 aagcgggaca ggctgtatct gacgatattg aagtcggaat gatggttgag attccgtcaa 1373281 ctgcagtcat cgctgatcag tttgctaaag aggttgattt cttcagtatc ggaacaaacg 1373341 atttgattca atacacaatg gcagctgacc gtatgaatga acgtgtatct tacctgtatc 1373401 agccatacaa cccggcaatc cttcgcttaa ttacactggt aattgaagca gcacacaaag 1373461 aaggaaaatg ggttggcatg tgcggagaaa tggcaggaga cgagattgcg attccgatcc 1373521 ttctcggctt aggcttagat gagttctcaa tgagcgcaac gtctatcctt ccggcaagaa 1373581 cacaaatcag caaattgtct aaacaagaag ctgagtcatt caaagagaaa atcttatcta 1373641 tgagcacgac agaagaagtt gtcgcgttcg taaaagaaac attcaagtaa tgtacaaaaa 1373701 ccagacggcc tccggcctgt ctggtttttt tcataagtaa gggtatagaa ggacacaata 1373761 acatggctag gagggatagt atgtcaaacc aatttaacgc aggagatact gtttatgtga 1373821 tctacagaaa tccgcacgcc gccaatgtag cccacataaa ggaagccgaa attgtgcacc 1373881 atccatacca tgaaggcgag ctttccctgt ttatttatga aacctatcat ccattcgcag 1373941 aggacgatgc tgtgtttgca agctatgaag aagctaaatc gctttacaaa gaactgtttg 1374001 atattgatcc gtatgagtaa caaggaaatc attacaactc atatcctttc cgcctagtga 1374061 gaaaagtaac gttagtaaag gaaaaggatg tggcatcatg cagaacccat ttgttccgca 1374121 gcttgtgtat atagaaccga gggcgctgga atatccgctg ggccaagaat tacaagataa 1374181 atttgagaat atgggtattg aaatcagaga aacgacatcc cacaatcagg tgcgtaatat 1374241 ccctgggaaa aatcatcttc agcaatatcg caatgcgaaa tcaactttag ttatcggtgt 1374301 ccggaaaaca ttaaagtttg attcatccaa accctcggcc gaatatgcca ttccgtttgc 1374361 aacaggctgc atggggcatt gtcattactg ctacctgcaa acaaccatgg gatcaaagcc 1374421 gtatatcaga acttatgtaa acgtcgaaga gattttagat caggcagata agtatatgaa 1374481 ggagcgcgca ccagagttca caaggttcga agcatcatgt acgtcagaca ttgtaggaat 1374541 tgatcatctg acacacacgc tgaagcgcgc cattgaacat tttggccaaa gtgatctcgg 1374601 aaagctccga tttgtaacga aatttcatca tgtcgatcac ctattagacg caaagcataa 1374661 cgggaaaacg agattcagat tcagtattaa tgccgactat gtgattaaaa actttgagcc 1374721 gggaacttca cctcttgata agcggataga agcggcagta aaagttgcaa aagcaggcta 1374781 cccgctaggc tttattgttg ctccgattta tattcatgaa ggctgggaag aaggatacag 1374841 acatctgttt gaaaagctag atgctgcttt gccgcaggac gttagacatg acattacgtt 1374901 tgaattaatt caacaccgtt ttacaaaacc ggccaaacga gtgatagaga aaaattatcc 1374961 gaagacgaag ctcgaattag atgaagaaaa gcgccgttat aaatggggcc gttacgggat 1375021 cggaaaatat atttatcaga aagatgaaga gcatgcactt cgagaggcac ttgaatccta 1375081 tattgatacc tttttcccta acgcaaaaat tgaatatttc acttaaacgg gctgttgtga 1375141 tcaacagctc gcttttttat aaaaaacatt tttccattcc atcaaaacgc cgtaattcaa 1375201 tgattcttta tcctccaaat aattgctgac tacacgaata ggtgaacgcc cgcaacggag 1375261 gagaaaggac agcacagggt cgtttttcct gccttccatc acatcttcaa cgtactgaac 1375321 agcgctgatc tcgtgtgcgt atttataata caaaggaatg cggccgccgc cgagaaggcg 1375381 ttccagtctt ttatcaacag tcagctcata catcgtattc atcagccatt ttccgattcc 1375441 aagctttcga taatgaggag aaacagaaat atccactaca tataaagtat ttccatgagg 1375501 ttcatgattt ttaatcgatc cgttgtcagt tgcttgtgcc catgtatgat caggagaatc 1375561 aggctcaaat tgtacaataa gagcagtcat ggaaccgata attctgccat tgatgagcgc 1375621 gcataaagcg ccttccggaa aggttttgat atggctggca agctggtcct ctgaccacag 1375681 caattcctgg ggaaacggag gagggaaaca ttcttcttga agagaaatca gcctctcgat 1375741 gtcagtctca gtgtagtttc taatggtcag agcctcaaat tttctgccgt catgcacata 1375801 catttgtttt agtatgatca tcactctcct tatgttgttt cattataacg aagattgaat 1375861 tttcagtaaa tatattccga ttttcttata atttattttt tgattattca tttttcaaac 1375921 gaaagggccg atatagaaat taggagggga ttggtttgtt taaaaaactt cacatgaaga 1375981 ttgctgtttt tgtttcgatt atgttaatca tcacagttgt tctcttaatg ctgtcttctt 1376041 atttgacgct aaaaccgatg attacagagg atgggaaaaa tacaactcaa aacgtgacgc 1376101 agtcacttga acaaaatatt gaattgcaat taaagagtta tgccatttcg ttatcaagat 1376161 tggctaatgg ggaattaacg catacatttg taacgaaacc aagtaaagaa gcttctcggc 1376221 tgtttcacga tgacattaag caaatcaaag acaacgatga ttatgttgcg atggcttaca 1376281 taggcaccgc aaaaaaagaa atgtttacat atccaaaagc ggatttcgct gaggattacg 1376341 atccaacatc aagaccatgg tataagcttg cagctgaaac cccggatcaa gttgtttgga 1376401 cggaacctta taaagatgtc gtgacaggag acatgattgt tactgcatcg aaagcgatct 1376461 tagacaggca aaaagtgata ggggttgcca gctatgactt gaaactctct gctatccaga 1376521 gtatggtcaa taaacaaaag gtgccttaca aaggatttgc ctttttagct gatgcgagcg 1376581 gcaatctttt agcccatccg tcaaatcaag gaaaaaatat atcaaaggat caaacactgc 1376641 aaaccatcgc atccgagaaa aaagggatac aagatgtgaa tgggaaaatg gttgtgtacc 1376701 aaacgattgg cgagacaggc tggaaggtcg gaacgcaatt tgataccgat caattaatgt 1376761 ggatttcaga taaaatgaat cgggccaatc tttggatatc attgattgcg cttatcataa 1376821 caattattct cagctacttc ctggccaaaa cgataaccgg tccgatacag cagctgatcg 1376881 taaaaacgaa agctgtttcc gcaggcgatt taacagtgcg cgcggaatca aaatctaagg 1376941 atgaagtcgg tattttaaca agagatttca atctgatggt tgaaaatatg aaggaaatgg 1377001 ttgagcaagt gagactctct tcagggaaag tatctgacac ctctgaacaa ctaacggctg 1377061 tggctgccga aactaatgaa acaagcggac aaattgcaaa agcgattgaa gaagtagccg 1377121 caggggcatc ggaacaggct tctgaagttg aaaccattaa tgaaaaatcg gaaagcctgt 1377181 caacgaaaat caggcaaatc gctgaggagg caggcggaat taaagaacgc tcaaaatcgt 1377241 ccgaggatgc aagctataaa ggacttgacg cgctcggcca gctgctgatg aaatcaaacg 1377301 aagccaatat ggaaacgaaa aaggttgaaa cgatgctgct ggatttggaa aatcaaacta 1377361 agaatattga agaagtcgtt acagcgattt caaacatatc tgatcaaacc aacttgcttg 1377421 ccttaaatgc cagtattgag gcagccagag ccggagaaag cgggcgcggt tttgccgtcg 1377481 tagccgatga agtgcggaag ttagctgagc aatcagccct ttctacaaag catatcagcg 1377541 agactgtgaa gcttatccag cttgagacaa aagaggcctc tcacgcgatg gttgaggcaa 1377601 gcagaatgaa tgatgaacaa aacagtgcaa ttcacgaaac tggagaggta ttaaatacga 1377661 taactgcaga aatgcagtca ctggtacaag gtattgatca catttacgcg gaaattcaaa 1377721 gaatgagtga agaacagctt gcgatttctg aagccattca aagcatttca gccatatcac 1377781 aggaatcagc tgccgcagca gaggaagtga acgcatcaac cgatgaacag cttgtcaccc 1377841 ttgataaagt caaacactca acggaaacac taaaacatgc aagccaagag cttatgaaca 1377901 caattgcaaa attcacattg taatccaatt acatccccaa acatcatttg ttttggggat 1377961 tttttatttt ataagatgaa tagatatggt agtctagaaa atgaaggaaa aatgataaat 1378021 tttaactaaa atctaaacga aacatctggg aggaatgacc ttgaaaaaaa caattggttt 1378081 tatcggtctt ggagtaatgg gaaaaagcat ggcatcacat attctcaatg acggccatcc 1378141 tgtattggtg tacacccgga caaaagaaaa agcagaaagc atacttcaaa aaggcgcgat 1378201 ctggaaagat acggtcaaag atctttcgaa agaagcggat gttatcatca caatggtcgg 1378261 ctatcccagt gatgttgaag aagtgtattt cggaagcaat ggaattattg aaaacgcaaa 1378321 agaaggtgca tatcttattg atatgacgac atctaagcct tcgcttgcga agaagattgc 1378381 tgaagcggcc aaagaaaaag cattgttcgc tttagacgct cctgtttccg gtggagacat 1378441 cggtgcacaa aacggaacac tcgcgattat ggtcggtgga gaaaaagaag cttttgaagc 1378501 ctgcatgccg attttctctt taatgggaga gaatattcag tatcaaggac cggctggaag 1378561 cggacagcat accaagatgt gcaatcagat tgcaattgca gccggtatga tcggtgttgc 1378621 tgaagcgatg gcttatgccc aaaaatcagg cctagagccg gaaaatgttc tgaaaagcat 1378681 cacaacgggc gcagccggaa gctggtcatt gtcaaatctt gctccccgta tgctgcaagg 1378741 caactttgaa ccgggatttt atgtgaagca ttttattaag gatatgggaa ttgcactaga 1378801 ggaagcagaa ttaatggggg aagaaatgcc aggcttgtcg ctcgcaaaat ctttatatga 1378861 caagctagct gctcaaggtg aagaaaacag cggaacacag agtatatata agctttgggt 1378921 gaaataaaaa aagattgcct gtacgaaaca ggcaatcttt ttttattatt ttccgatgaa 1378981 ttgttgtgtc cagatgcttc cagactcaac gtaaccaaca ccgatgtgag taaagttagg 1379041 gtttagaatg ttttttctgt gtccttcact gttcatccaa gcttttacta cttcttctgg 1379101 tgtcttttgg cccttcgcaa tgttttcacc tgctgttttg tagctgattc cgaaagattt 1379161 catcatatca aacggtgagc cgtatgttgg gctttggtga tcaaagtagt ttttgtcttt 1379221 catatcctga gattttgcgc gtgcagattt gcttaacgtt tcatcaattt gaagcggttt 1379281 taagccttgt ttttgtcttt ctgcatttgt aagttcaaca acttttttct catatgcact 1379341 tacagatgaa ggtgcagacg ttgttgtgtt tgttttttca gcagttgcgg gtgctttaga 1379401 agcagtgttt tgatcagcag ctgctttttc agtagtcttt tgtgcaggtt ttgccgtttc 1379461 tgtcttttga acatcctgaa ctttcacgtt agattgcttc gcatgttttt gaagaagctg 1379521 cttcatctct ttttcgtttg cagcgtttaa cgttttgata tttgtgttaa tatgcagttt 1379581 tttcactgca tcgttaagtg acatgttttg tactgtgttc cccgttttta ctgtaaccac 1379641 aggctggcag gagagttctt tcgctgatgc ttgctgtacg cccccgaatg tgaataatcc 1379701 aaccgcagcg gcagcagata aaataaatgc tttcttcatt agttcgtaac ctcctagagt 1379761 tgtttgtttc tacagaaaaa tcataacata gcttttttgt cataaagatt ccagcacttt 1379821 cctttgacaa atagagattg tcattttcgt aaagtaaatc cgttgaatca ctaagaataa 1379881 gggaatcagc ggtatatatg attttatcgt accgttacat agcttccttt tttttgaacc 1379941 gttagttata ttttaatgtg tttttatatt gacagctttt tttactcctt ttcgctgtaa 1380001 caactattac aaaggtgtta caattaatct cagtatatgt aaatatattg aatgatttga 1380061 gaggggtaac cagaagtgac tgaaatagga cgtgaaccaa agaaaaagag caaaggaaac 1380121 agagcaatca gaatgaacct ttttttccta gctgtctttg ttctattcac tgcattaatt 1380181 tttaagctcg gggttgttca aattgttgaa ggcgaacagc atgaagaaga cgctgagaaa 1380241 tcaaatgcaa aaacagctta ctatcctgcg cctcgcggga agatgtacga cagaaaccag 1380301 aaagttgctg tcgacaacca gagcgttcca gaaattgtgt atgtatcaac atctagcaca 1380361 aaaacagaag ataaaatcaa aacagcgaag cggcttgctt ctttcattca tattgatacc 1380421 gaatttttga aggaaaggga tcttcgtgat tactggatcg cagctcatcc gaaaaaagcc 1380481 gccgctctgc ttaaggaatc agaaagcaat ctgaaaggag accaggctta caagcttcaa 1380541 atagagcgtg ttccggatca agaattaaag gctattcagc aagatgacga agaaatggaa 1380601 actgctgcga tatatacaag gttttcaagc ggaaatgctt acgaacctca aatcgtaaag 1380661 gcaatgaatc caaataagag caatagcaat ggaaaaaacg gagcgctgct tgatgagaag 1380721 aaaaactcct cgcaaagacc aaaaaatgac ttaacatatg atgaaatttc cattgtttct 1380781 gagcatttag aagaacttcc gggaatcgat atcgtaaacg attggacacg aaaatatcct 1380841 tatgacaaaa ccctttattc tgttttcggg ggcgtcacga cacctgatca gggcctgctg 1380901 agcgaccgga aagatttcta cttaacaaga ggctatgcga ataatgacag ggtgggaaaa 1380961 agttatttag agtatcaata tgaagaatat ttaaattcgc ataaagaaaa agtggaatac 1381021 gtagaagata ataaaggaaa tgtcgtcagc caaaaaacca ttgataaggg cagcagggga 1381081 tacgatcttc agctttcttt tgacatggag cttcaggcaa aggtagaaaa gatcattgaa 1381141 gaagaagtaa gaaacagccg tgcacgcgga aattacatgc ttgacagagc ctttgccgta 1381201 atgatggacc cgaataacgg cgatatttta tcaatggcag ggaaaaagat agatttaaaa 1381261 accaacaaaa ttgaagatta tgcgataggg gcatttacca cccaatatga aatgggatca 1381321 gcagtaaagg gggccaccgt gctagccggc tatcaggacg ggatcccgca ttataaatat 1381381 tatatcgatg ctccaatgct tttaggaacg aatcttataa aaaaatctta tactaatatg 1381441 ggaaccatca atgaattaac cgcattgcaa aaaagttcaa acgtatatat gttcaatgtt 1381501 gccatgcata ttgcaggcgt aacatacaag ccgcatggat ctctcccggc tgatcagaac 1381561 gatctactga aaatgagaaa ctattacagc cagtttggtc tgggagtaaa gacaggtatt 1381621 gatctcccgc aggaatcagc cggaatgcaa accacaccta aaactgtagg aggattaatt 1381681 ttagacttag caattggcca atacgataca tacacaccgc ttcaaatggc tcaatacatc 1381741 tcagtaatcg ccaatggtgg ctatcgtgtt cagcctagaa tcgtcacaag tattcataag 1381801 ccaggaaaaa aagaccagct gggtaaggcg attgaacata ggaaacctaa agtactcaat 1381861 aagattaata attcagagag cgatttgaaa caagtacaaa caggcatgaa attagtcact 1381921 tcttcaggga cagcaaaaaa tacgtttaca gaagatgtat cagggaaaac gggaacagcg 1381981 gaaacatttt actacggcac gaatcgcaac tggtggggga aaaaaacata caatctgact 1382041 tttgtcggct attacccgtc gaaaaaacca aaagtggcct ttagtgttgt tgttccatca 1382101 gtagatgatg atgataagat caataaaatt attgccaaaa gagctatcca cgcctacgca 1382161 gagctcgaaa aaaaacacag taaaaaataa aaaacagggt gcacaactaa aagattgtgt 1382221 gccctttctt ttattcaaaa attgacgttc accataagaa tagaaggaga atactcattt 1382281 tctagcgaat catactaggt aaaagtcaat ctgtatatgt cgaaacacga tgatcatgca 1382341 aaggagggat tctgtggaac aggatacgca gcatgttaaa ccacttcaaa caaaaaccga 1382401 tattcatgca gtcttggcct ctaatggacg catcatttat atatctgcca actccaaact 1382461 gcatttgggc tatctccaag gagagatgat cggatcattc ctcaaaacgt ttctgcatga 1382521 ggaagaccaa tttttggttg aaagctattt ttataatgaa catcatctga tgccgtgcac 1382581 ctttcgtttt attaaaaaag atcatacgat tgtgtgggtg gaggctgcgg tagaaattgt 1382641 tacgacaaga gctgagcgga cagaacggga aatcattttg aaaatgaagg ttcttgaaga 1382701 agaaacaggc catcaatccc taaactgcga aaaacatgaa atcgaacctg caagcccgga 1382761 atcgactaca tatataacgg atgattatga acggttggtt gaaaatctcc cgagtccgct 1382821 atgcatcagt gtcaaaggca agatcgtcta tgtaaacagc gcgatgcttt caatgctggg 1382881 agccaaaagc aaggatgcta ttattggtaa atcgtcctat gaatttattg aagaagaata 1382941 tcatgatatc gtgaaaaaca ggattatacg aatgcaaaaa ggaatggaag tcggaatgat 1383001 tgaacagacg tggaaaaggc ttgatggcac acctgttcat ttagaagtga aagcatcccc 1383061 gaccgtctac aaaaaccagc aggctgagct gctgctgctg atcgatatct cttcaaggaa 1383121 aaaattccaa accatcctgc aaaaaagccg tgaacgatat cagctgctga ttcaaaattc 1383181 cattgatacc attgcggtga ttcacaatgg aaaatgggta tttatgaatg aatcgggaat 1383241 ttccctgttt gaagcggcta catatgagga tttaattggc aaaaacatat acgatcagct 1383301 gcatccttgc gatcacgagg atgtaaaaga gagaatccaa aacattgccg agcaaaaaac 1383361 agaatctgaa attgtcaagc aatcctggtt cacctttcag aacagggtca tctatacgga 1383421 gatggtctgc attccgacga ccttttttgg tgaagcggcc gtccaggtca ttcttcggga 1383481 catctcagag agaaaacaaa cagaagaatt gatgctgaaa tcggaaaaat tatcaatcgc 1383541 agggcagctc gcggcgggaa tcgcccatga gatccgcaac cctcttacag cgatcaaagg 1383601 atttttacag ctgatgaaac cgacaatgga aggcaacgaa cattactttg atattgtgtt 1383661 ttctgaactc agccgtatcg aattaatact cagtgaactg ctcatgctgg cgaaacctca 1383721 gcaaaatgct gtcaaagaat atttgaactt gaaaaaatta attggtgagg tttcagccct 1383781 gttagaaacg caggcgaatt taaatggcat ttttatcaga acaagttatg aaaaagacag 1383841 catttatata aacggggatc aaaaccaatt aaagcaggta ttcattaatt taatcaaaaa 1383901 tgcagttgaa tcaatgcctg atgggggaac agtagacatt atcataaccg aagatgagca 1383961 ttctgttcat gttactgtca aagacgaagg ggaaggtata cctgaaaagg tactaaaccg 1384021 gattggagag ccatttttaa caacaaaaga aaaaggtacg gggcttggat taatggtgac 1384081 atttaatatc attgaaaacc atcagggagt tatacatgtg gacagccatc ctgaaaaagg 1384141 cacagcgttt aaaatttcat ttccaaaaaa ataaaaacaa cggcttaaac gccgttgttt 1384201 atcgtctgca ttgcttcacg tttttttaat acaaataatt ctaaacggtc taggccttct 1384261 ctcagcgtgt ccattgagca tgcaaaagac agccttacat atccttcacc atatgttgag 1384321 aacgagctgc ccggcacgag tgccacgcca gcgtcttcca aaagagccat actaaaatca 1384381 aatgaagtca ttccaaatga tttaatagaa gggaagatat aaaacgcacc ggacggttta 1384441 actacgtcaa gtcccatgga aacaagacgg tcataaacat agtccagacg ttttttgtat 1384501 tgttctctca taatcaatgc atcgtcaaag ccgtttgtga cagcttcaag cgcggctttt 1384561 tgagaaatgg atgaggcgca cgacacattg tattgatgaa cctttaaaat gtgctttgca 1384621 atgtctttcg gtgcaaataa aaatccaatt ctccaaccgg tcatgctgtg tgattttgac 1384681 aacccgttaa tgacaatcgt ttgatcccgc aaataggttg cgatggagta atgcggtctg 1384741 tcatatgtta attcactgta tatttcatca gacaatacga agacatttct gccttttaag 1384801 agagctgcga tgcttttcag ttcttcttca gataaagtca cgccggtagg gtttgacgga 1384861 taaggaagca cgacacactt ggtgttgggt gtcagagcat cttcaatcag ccgggcggta 1384921 agcttaaagc cgtgtgacgt agtatcaaca atgacaggct tggccccgca caaattgata 1384981 ataggttcat agcccggata aataggccct ggcataatga cttcatcacc gggagataaa 1385041 atcgtccgga atgcagcatc aatggcttgg cttgcgcctg ttgtgatgat aatttcagat 1385101 tcagcatcat agttgaaatc cgcttttttc ttcatataaa gctgcacagc ttgtctcagc 1385161 tccaggtagc cggcattcgg agtatatgac gtcacgtttt catcaatggc tttttttgcg 1385221 gcagctttca catgatgcgg tgtgaaaaaa tcaggctggc cgattgtaag tgaaatgacg 1385281 tcttcgtgtt gggctacaag attcgagaat ttgcgtattc ctgaaatttc gatctctctt 1385341 gctttcggat tcagcaaatg ttccataatt catcacctta acaaatataa tgagtttatc 1385401 ctattttacc actagctgat catttgtcac ctttttaact gatatatttc gattgtatgc 1385461 gccttttttc taaacatacc tttcttttca gaaaaaaaga agacaaccag cgatttgatt 1385521 gtctttattg tatcatgttc tattattgtt tatatgtgcc aatttcatta atagccataa 1385581 tcaaaatgaa ggtcttcgtg ccaaatcaga tacggaggat gctcttcttg aaggtcagct 1385641 gattctttct tcatattcag gtaagtttct tcactgatat cctctaaaac agtcatttcg 1385701 ttttctttaa atattactaa ggtacccatt atttacaccc ttctttggaa aaatccttga 1385761 ctattttatc actgttagtt ggaaagtcaa tggttattag gaaaaaagtt tcttttttga 1385821 ggaacgcggc ttgttgcctt cggaattcga ttttgaagag ctgccattca ctttttacaa 1385881 attacgccga tatatacagt acaatactga atgcgaatag cgagggattg aattgtcgtt 1385941 acaacaatac gaaattttat tggattctgg tacaaatgaa ttagaaattg tgaagtttgg 1386001 cgtgggtgaa aatgctttcg gaattaacgt catgaaggta agagaaatta ttcagcctgt 1386061 cgaggtgaca tcagtgcctc actcccatca gcatgtagaa ggaatgatta aactcagagg 1386121 agaaatcctc cctgtgatca gtctcttctc attttttgga gtagagcctg aaggatcaaa 1386181 agatgagaaa tatatcgtga ctgaatttaa taaacggaaa attgtttttc atgtcggctc 1386241 tgtttctcaa attcacagag tatcctggga agcgattgaa aagccgacat cgttaaatca 1386301 aggaatggag cggcacctta ccggtattat taagctcgaa gacctgatga tctttttgcc 1386361 tgactatgaa aaaattattt atgacattga atcagattca ggtgttgaca cgtataatat 1386421 gcataccgag ggcttcgatg aaagaagaac tgataaaaag cttatcattg tagaggactc 1386481 accgcttttg atgcgcctct tgcaggatga attaaaagaa gcagggtaca acaatatcgc 1386541 ttcgtttgaa aatggaaaag aggcatatga atacattatg aaccttgctg aaaacgaaac 1386601 tgatttatca aaacagattg atatgatcat cactgatatt gaaatgccaa aaatggacgg 1386661 acacaggctc acaaagctgc tgaaggaaaa tccgaaaagc tcagatgtgc cggttatgat 1386721 tttctcatcg ttaattacgg atgatctgcg tcaccgcggc gaagttgtag gcgcagatga 1386781 gcaaatcagc aagcctgaga tcagtgattt gattaaaaaa gtggatacgt atgttattga 1386841 ataaataaaa acagccgttg ccagaaagag gcacggctgt ttttatttta aaagtaactc 1386901 tcgccaagtt ttttaaagac cggtttatgg taagctggct gctggcgatt tggcactagc 1386961 ggcttttctt tcatgccgac atattcttgc aataggtgtt tcgcttttgt taaagacatt 1387021 tgagctttag gatttcgata cgattgatta agtgtaccta aatgcggaag atgttcgaag 1387081 tcttctttag ttggaggcat gtgaaaatag tagtctccga ttgagataag cacgtccgat 1387141 tgctgttggc tgaaccttgg attttttgaa aaatgaagcc ctattttctt tcctttacct 1387201 tctttgacaa gcttttgcaa agcccgtttt ttcagcagat ataggtattt agggttgggg 1387261 gcggtttttg catggcggtt cacagtgtaa actgcttttg aaagattttc tacggttggc 1387321 tgcagatctt tcgtatatgc atggtcgtcc attatttctc tcctttgctc ttatcaattt 1387381 ctatatgttt agattatact tttttaaagt tgaaatgcaa atattgaatg taaaaatgcg 1387441 cttttttcta agaaaaaaag cgcattttta acctgcatta tacagatctt gccttctttt 1387501 tcggctgttc ttgaaatgct tcctgaacat tcacttccac agcctgagca ctgtattttg 1387561 gcagtgcaat aaaataaaaa ataaaaacga gcaggataat aacacccatg ccgtaataaa 1387621 gataatcaat gtttgaaaca aacttaggga ataacagcgc gactaagccg agtgtcaaag 1387681 attgtgcaaa catcataaaa gggtcctgca tgccgcttac acgtcccatc agttttggat 1387741 gaacaatttt tggcatccac cctccgattg caatgttgat cggtccgata cacattccca 1387801 gtgcaaaagc tgccgcgtaa tacacccata aaatattggt gtagccgagg acgaagatca 1387861 gcaaacctgc aatgaaaatc ggtatcgaca ttaaaaagtg cggcttcact tttttagaga 1387921 tgagcgtgcc gattacgctt cctgccagaa gcccaaaccc gagtgcgatc gtaaatacag 1387981 acgtatgcca ctcataacgg tcaggcgcca atccatattt cattgtaaac atcggcaata 1388041 cggcgaatcc tccattgaca aatccaaaaa tgaagaagcc aaaaataaga gatgccagca 1388101 atttgttttt taaaatatag aggatgcctt ctctaaagtc atttattgaa tccttaacag 1388161 aagtctttct ccagctgaat gcaccgtttg gctgtcgggc ttcttttgga atccggcagc 1388221 tgcggatcag cagcccggaa atgataaagc tgacaaaatc aagaataatg gcgccttcaa 1388281 taccgattgt gttgtacata aacgcgccta tgccgactcc aaacaccata aaaatgctaa 1388341 aaagcatctg attaagccct gccgctttcg cataatgctc cttcggcaga atggcttgta 1388401 ccaaactgtt ttctgccgga aagaaaaact ttgttacagc gcttctgata aataagatac 1388461 aaaaaacaag aggaatattg ccggtaaata aagtgaaaaa aagcacgaca gtcaggcctg 1388521 ctctgatcca atcacaattt tctgccacct tttttctatc aaaccggtcc gcgacgactc 1388581 ccacgatcag aaatacaaat atggtcggaa gagaatacat cagctccgcc aaggtcgtat 1388641 atgaaggctg gctgctgaat cggtccagca aaaaaaaagc aaaggccatg ttgcctactg 1388701 tcgtgcccat ttgagaagcg agtgctgcga aaaatagacg aacaaaatta cgatttttaa 1388761 atatatccat aaaaacgctc cttaccctaa aggtcccact ttatcatatt ataaaccgcc 1388821 tgtttttgaa acaaataaga aaacattacc ggttaatcgt gactctcgtt ccgtttggca 1388881 caattgaagc aagttcgatc acgtctttgt tatgcatgcg aatgcagcct ttagaaacag 1388941 ccttaccaat cgaagcggga ttattcgtcc catgtattcc gtagtgctgc tttgaaaggc 1389001 tcagccaata agcgccaaat gggccgccgg gattgcgctg gcggttaata atgtaaaact 1389061 cgccagtagg cgtttgcgtt agtattttac caacggcgat gggataggtt ttcattaccc 1389121 gattatttag ggacagcgta agggtcttcg ctccgattga gactgcgata tgatacggaa 1389181 ttgtataagg gtccggcagt ccggggatga ctatggactg tcccgcggtg agccctgcct 1389241 gcagtgacgg attagcctgg agtaatgcag ccgtgctgat tctgaaatca gccgcgatgc 1389301 tgttcagtgt atcaccttgc ttcacctggt acgtaagcag tttcctcatc ctcctttttt 1389361 acttataagt attgatgagg agcccatcct gctacattaa tttgtgcttt ttaaggtgaa 1389421 gacagtgatt tcaggcttgg caagaaaccg caaaggcagc ctggtcatcc cgaggcctcg 1389481 gtttacgtaa atatgagtgc tgcccgtttg atacattccc tctgtgtaga cttttccata 1389541 tggaggcgta ataatcggtc cgtaaaaagg cagctgaatc tggccgccgt gtgtatggcc 1389601 ggaaagctga aggttcacgg gataatctgt tgttttcaag gctgcatcag gttcatggac 1389661 gagaagaatg gaaaaaagtc tgtcgctcag ccttgaaagg gtgccttcat aatctgggtt 1389721 tcccagcatt aagtcatcaa gcgaagcaat ctcgattttg ctgccatctg cgagtgacaa 1389781 tgtttgatag ccattgcgat ataccgtgaa acctccggcc gtcatcaggc ttttgtaaac 1389841 ggcagttcca tagcctccgt gatcatgatt gccgtaaata caaagcttgc cgaagggagc 1389901 attaagcttt ctcaataatg gaatgactgc ctggtggtgc tggtacgtat caggattatc 1389961 aataatatca cctgtaaaaa caatgagatc aggtttagat tcattaattg taagaatgac 1390021 agtttttaaa tcttcgagag taaagtaatc actcaagtgt gcatcgctga actgcacgat 1390081 tttaaaaccg tcaaatccgt gcgggatgag agagcttttt attgtgtgtt cggttgtctc 1390141 gatcatatgc ggctcgagat acctggcata gccatatccc ccgccggccg ttaaagcccc 1390201 ggcagcaaga gcgccgaaca ttccttttag aaattgtctt ctggacatct ttttcatttc 1390261 aaaccaacct ttaatagagt ttttctatta tatcatctgt atctgataaa aatctcatat 1390321 gagcatgtgc tgacagaggc agggatataa tgatagaata ttattgaatg aataatcatt 1390381 cacaattgga gggataaaca tggaaaaaaa ggcggtaatt attaccggcg ggtcaagcgg 1390441 catgggaaaa gcgatggcaa aaaaacaggc tgaattaggg tggcacgtta tggtgacagg 1390501 gaggaaccat gaggcacttg aggaaacaaa aaaagaaatt cagacctttg agggacaggt 1390561 cgcttgtttt caaatggatg tccgttccga ttccgccgct tcagacatga ttaaagaagc 1390621 ggtaaaagcc tttggccggc ttgacgcgct gattaacaac gcggccggaa actttatttg 1390681 tccggcagaa aagctgacgc ccaatggatg gaaagccgtt attgagattg ttttaaacgg 1390741 cacatttttt tgcagccaag cagcggcaag gcattggatt gaccagaagc agcagggtgt 1390801 cattttaaat atggcagcca cgtacgcttg gggagcggga gcgggggtcg ttcattccgc 1390861 tgcagccaaa gcgggggtat tgtcattgac aagaacgctg gccgttgaat gggggagcaa 1390921 atacggcatt cgtacaaacg cgatagcccc cggaccgatt gaacgaacag gcggtgcgga 1390981 gaagctattt gaatcggaaa aagcgatggc ccgcacgatg aacagtgtgc cgctcggccg 1391041 attgggcaca ccggaggaaa tcgccgcttt ggcagcgttt ttgctttctg atgaagcatc 1391101 ctatataaac ggggattgta tcacaatgga cggggggcaa tggctgaatc cttatccgtt 1391161 ttaatctgaa tatttataag tgaatattta agttattaag aacttttatg ttcgaatgta 1391221 atacctccac aattaacctt cttcctatcc aatttgataa cacatagagc tttatttgtt 1391281 tatgaggtgt tgtgtcatac gtaagccacc taatatatga aaggtatatt ttaaaagggg 1391341 agacgaaata tgaagaactt agatttcaaa taaaacattc atataattac ttcgttaact 1391401 aaaaagagaa attataagaa tgaaaggttt caaggttaca tcagattggg aggaaggtaa 1391461 tataatggac gagatggtat tattaactca ggaatggctc aatgaaacgt acaaaggaaa 1391521 aagtggctac aattccattg aggaaaatgg gaaaactggc tggaaaacaa tgtatgcatt 1391581 aactagagca ttacaactag aattgggaat tacacagact tccgacagtt ttggtcctac 1391641 aactttaaga aagcttaaag aattaggccc gatttctacg tcaactaatt caaaaaaaaa 1391701 tattgtgaaa attattcaag gtgctcttta ttgtaaaggt tatggtccag gtggattaac 1391761 gggtacattt ggtcagggaa cgaaagaggc gatagcagaa atgcaattgc atatggggct 1391821 ttctaaaaca gacggtgtag taacgcctaa ggtgtttaaa gctttattaa acatggactc 1391881 ttatatcctt ttaaatgggg cgtcagagaa agttcgttca atacagcaat ggctaaataa 1391941 taaatattac aatagagaga atttctactt tatgccctgt gatggcctgt attcaaggga 1392001 tactcaaaag tctcttgttt atgcaataca gtacgaggaa gggttaagtg atagtatagc 1392061 taatgggaat tttggaccaa ctactcaaag attgattcct gtattaagaa ttggagaaac 1392121 agatgaaaaa aacagtttta ttcatttatt tcaagctgct ctaatcttta atggctacaa 1392181 tgttcctttt gatggagtat actctgaatc tgtaagatca aaagtaaagg cttttcagtc 1392241 ttttgcaaaa ttacaacaga gtggtactgc cgactttcaa acatgggctt cacttctagt 1392301 aagtactgga gaccccaatc gaaaaggagt tgcttgtgac tcaattactc aaattacatc 1392361 ggacagggcg gagtccctta agagggcagg ttataagatt gtagggcggt atctaacaaa 1392421 tgcgccgggg agtacactaa ataaaaaaat acaaccaggt gaattagaaa ctatcttaaa 1392481 atcaggttta aatgtttttc cgatttatca aacctatggg ggagcaacaa attattttaa 1392541 taaagaacaa ggaaagaaag atgcgtttgc tgcttataaa gcagcaaaag aatacgggtt 1392601 taaaaataac actgtaatat actttgcagt agattatgat gcatatggta acgatttaaa 1392661 caacaatatt attccacact tcgaaggtat aaatgaaata atgaacggtt ttttaggttc 1392721 aacttacaaa attggtattt atgcccctag gaatgtatgt actatagttt ctaaaaaagg 1392781 tttagcattt gcaagttttg taagtggtat gtctactggc tttagcggaa acttaggata 1392841 tcctttgcct tacaattggg cgtttgacca aatttcaaca attactgttg gaaatggttc 1392901 tggaatgatt gaaattgata atgatatttg ttcaggtttg gataatggag ttaataccat 1392961 aaatatagtg ccttcagaga ataagaagtt ttttgatcaa attgatgttt tatatgaaac 1393021 tgctgaaaaa tatgctcaaa tgcaaagcga cttaaataat ggggtaaaaa aaacacaatt 1393081 agctaatgag ttggttgccc agtatttaag aaaggatgac tacaaagggt ggaagtgggt 1393141 ccctaccgca ggccagattg atcctattta tcgtgaatgg gcagtaaagc gctaggggaa 1393201 gacctagtaa atggaattgt tgatcctata tcaaaaactg tcataggaac gcagcatctt 1393261 atggcaactt ataatgccat tatttatagt ggtggttact ctcaaacact acgagatttt 1393321 gctggttgga ctggagatct attaacaaca atacaggaca tgaaattaca cgctcaagaa 1393381 tttaattcgc cttatgatgc ggctatgaaa ataataggta atatgtatca atttagccta 1393441 gatgatttat ttagtgatgt agatgcaatt aatctagcga ataaaacatc agttggtgct 1393501 aatgcacaac ctctaaatat cgcaattaga gattattata gtaataatga ctgtatgaat 1393561 aggttcactc aatttgtaaa taatagattt gatggttcgt tagacaaaat tttctctgaa 1393621 gcagagtatt atttaaatac aaaccttgac ccagttgttg ttccaattag gttagccttt 1393681 aaacgtgctt ttgatgttga ggattatagt gaagagattg gaaaaataac agcacaagca 1393741 tttagagatg ttatcgagaa aaaaatgata tctgaataaa ctgcaaaaca agcgaacgtt 1393801 aaaactggtc gttcgcttgt tttattttct atttaaattt atgatataat ttttaaagat 1393861 taaggagtga ttcattgaag aaattgttaa aaaagttagt tgtattattt ttaagcagtt 1393921 tagttatcat ctttaatgtt tggtacttta ttatttgtgc tttttcccca gagtattatc 1393981 aaaatacaaa tcttacttct aatgaaataa taagatttga aaaactatac cacatagatt 1394041 ttcctgatga aacaaaattt attaaagcta gagagtattt ggctgggccc ggaggagata 1394101 cgtcagctgt attatatgtg tctctgccaa ccaagcgggt agaaaaagtt ttatctgatt 1394161 acacgtatat gaaaataaac tatactgaca atgtcggttc aatgtatgga gttgacgttt 1394221 caaagagtgt cgccggttta acaactctta catttggcac ttacgataaa aaaggaactt 1394281 tctataatat gaaacatgat gatgattgga tgtataaagg cactgactgg aatctttact 1394341 tttggacagc tgctagttat aatgctgtta tttttgtatt tgttttggtt attgtgaaac 1394401 aaatgaataa aattcttaat taaccagtat gtagattgat aatctcaaaa aaattttcct 1394461 cttcttttaa catactccat acgacctact tttccatact atgatttttt tgaaatttgt 1394521 ggtgtagtta taattgtgcg tataatcaga caaagataga gaagcaggtg ataacatgtt 1394581 ggatccactt gatattttaa cgaacattga tgatgtcctt ccatattacc aggcgatttt 1394641 tagtgccgag gagcagaagg ttgtcggata tgaggtgctt ggacgaattt tggcagattc 1394701 agaaatccaa agtctcgggc ccttcttttt agatgcgggg atacccgaag aatataaatt 1394761 agaggttgat aacagaatta tccgccaggc tcttgaccgc tttttagagg cggattctga 1394821 tctgctgatt tttatgaatc aggatgccaa tctgctgatg ctggatcatg gtgaaagctt 1394881 tctggagctt ctgaaagaat atgaagcgaa gggaatcgaa ctccaccgtt ttgtgcttga 1394941 aattacagag cacaattttg aaggggatat tgagcagctc taccatatgc ttgcatacta 1395001 tcgtacatac ggaattaaaa tcgcagttga caacatcgga aaagaaagca gcaacttgga 1395061 cagaatcgcg ctgctctcac cagatctgtt aaaaatcgat ttgcaggcgc tgaaagtgtc 1395121 acagccgtca ccgtcatatg agcatgtgct gtacagcata tctttattag caagaaaaat 1395181 cggtgcggcg ctgctgtatg aagacattga ggcgaacttc cagcttcagt acgcctggag 1395241 aaacggaggc cgctattttc agggctatta cttagtgtct ccatctgaaa cgtttctaga 1395301 gagagatgta ttgaaacaaa gacttaaaac tgaatttcac caatttatca cacatgagaa 1395361 aaagaaactg gagaccgtct atgagcactc tgaacagttt tacaaacgag tgcatcaggc 1395421 tgtgacctct ttgagaaaaa acaatctgtc ttctgatgat gactttatta aaaagctggc 1395481 ggaagagctg acagattgca gcttcaggat ttacatgtgt gatgaagaag gcgatcagct 1395541 gacgggaaat gtgtttaagc aagatggaga atggatttat cagccggaat atgcggaaaa 1395601 gaactggagc tggcgccctt attttctgga gaacattatg agaatgagaa atctcagaaa 1395661 aggttttttc agtgatctgt acagtgattt ggaaacaggt gaaatgatca gaacgttttc 1395721 atatccgatg gatgatcaga tgtatttatt tatagacttg ccttattctt atttatatga 1395781 gcaggacgga ctgatttaac ggctgaaagg ccgttttttt tatgaaatga aaaaaatatc 1395841 aaaaaacgat tgacattgat actgagaatc attatcattt aattatagag agaagctact 1395901 ctctgttccc caacccctct atcagatcaa gatccgaaaa aacttggcgc tacccccgcc 1395961 aagtttttta tttgtcaaag cataggacaa tccaatgaaa caataaacct aactagtggt 1396021 aaacgtttaa cacggggaga aacattgagt gccgaacacc cctgacactg ctgcacgggt 1396081 gaggaggaaa attcgttctg aaatgattat ttcagttccg ttgtttacct ctatccagca 1396141 tgactcccat tgattatggc cacgcgggac ttcaccataa aattcaaaag aaggttttga 1396201 caaagttgca aaaaggcatt cttaatgctg ccaaagattc gaaaaaaatt ataattatgt 1396261 gcatgacatt caaaaaaagc ctcaaactaa agaaaaatag tttttttcac tttttttctt 1396321 tgcttaaatt cagcagtgaa aatgccatcc tgtccgactt tatggtatga tgctcaatag 1396381 aacttgtatt ataataaata cttgttgatt tgaagttgct ttttgaaagg agtctttttt 1396441 tagaatgtca caattaatgg gtatcatcac acggctgcaa agtctgcaag aaacagcgga 1396501 agcggctaac gagccaatgc agcgttattt cgaagtgaat ggtgagaaaa tatgcagtgt 1396561 taaatatttc gaaaaaaatc aaacgtttga actgacggtt ttccaaaagg gtgaaaaacc 1396621 taacacatat ccgtttgata atatcgacat ggtttccatc gaaatctttg aacttcttca 1396681 gtaagattcc tgaaataggg ggaacaagct tccgcctttg caaaagtaat cgaaataaac 1396741 ggtaaggaac atacttgttt catggttgta aatccttgaa aaggagtgtc gtgatggctg 1396801 attcttttct gttttataat ctttcagaag cacagatgac ctttcaagat gtgatggaac 1396861 ggcttaaagc ctttgttcaa aaggaccccc gttcttctta tgtgttatcg atcggaaccg 1396921 attcacaggt ttaccgcgat tacacaaagt ttattaccgc attgcatttg catcgtacag 1396981 gcaagggagc ttggggctgc ttgaaaaatc atacagtcga cagacccata catagccttc 1397041 gggagaagat ttcgttagaa acggcgtaca gccaagaaac ggccgctcat attcttgatg 1397101 gacacttaat ggatattacc gatctgctcc tgccctttac cggtgagggg gcggatctta 1397161 cctttgaagt tcacttggat attgggaaaa aagggcttac aaaagatctg atccaagaaa 1397221 tgactggacg tattacctcc atggggattg aggccaaaat aaagccggat tcatacactg 1397281 ccttcagcta tgcaaatcgt ttcacaaaat aatttggctg aaaaagccaa ggtaaatgtc 1397341 gaattatgcg gttgacgttt gttatctgat tacttattct agcggtagag ctgaaagtaa 1397401 gttgtcttgc tttcagaggt attcagtata aaacaggggg cctgattgcg aatgagtctt 1397461 atcggtgaac gatttacaga agaagaacaa aaacttctgc tgaatatcct gatcaaccat 1397521 gagtatgcca tcgagctatt aagcagtgag atcaacgata tagagacagg gaccaaaaac 1397581 gttgacggaa ccacctacaa aaaacttgta acgctatacg accgatttcg atttgaaaat 1397641 taatgggaca ccctataatt gatactccac aaagagtatc ttttttattg aaaggaaact 1397701 tttcgacaaa tactgataaa gtttatatta ttgcaatata gggaatgtat tgatgatgaa 1397761 aatgaaaagg ggtcgaaaac atgataagct tacaatcaga tcaacttctt gaggcaacag 1397821 tcggacaatt tatgattgag gcggacaaag tagcgcacgt gcaagtcgga aataaccttg 1397881 agcatgcatt attagtattg acaaaaaccg gatacacagc catcccggtt ctggatcctt 1397941 cctaccgttt acatggctta atcgggacaa atatgatcat gaacagtatt tttggacttg 1398001 agcgaattga gtttgaaaag cttgaccaaa tcactgttga ggaagtcatg ctgaccgaca 1398061 ttccgcgcct tcatatcaat gatccgatta tgaagggatt cggcatggtc attaataacg 1398121 gatttgtctg tgttgaaaat gacgagcagg tatttgaagg gatttttacg agaagagtcg 1398181 ttttaaagga attgaataag catatacgct cattgaataa gtaggctgta cggtcctatt 1398241 tttattatat aggcagagtg aaaaaagaaa gcgcatacat aatttaaacg agaatagggc 1398301 ttgaataaga aactaagatt ttattagaat gggagataag aaaaacttat tgataacaaa 1398361 aaggaggacg acatgcagct tcaagagctt catatgctcg tagttttagc tgaggaatta 1398421 aatatgagaa aggcggcaga acggcttttt gtatctcagc cggctttatc tcagcgctta 1398481 caaaccattg aaaaggcgtg gggaacaaaa atctttttaa gatctcaaaa aggattaacg 1398541 gtaacgcccg ccggtgagaa aatcattcag tttgcgaatg atgtgacatt agagcaggaa 1398601 agaataagag aaaatattga cgagcttgaa ggtgaaattc acggcacatt gaagcttgcc 1398661 gtcgcctcca taatcggtca gcattggctc cctaaagtcc tgaagacgta tgtggaaaag 1398721 tatccgaatg caaagatctc gctcataacc gggtggagca gcgaaatgct gaaaagcttg 1398781 tatgaggatc aggttcatat cggcattata agaggcaacc ctgagtggaa ggggcgcaaa 1398841 gattacttaa tgacagatca tctgtattta gtggatactg aaatttcctg catcgaagat 1398901 attgcccata cagaacgtcc gtttatccag tttaaaagtg acagcactta ttttcaggaa 1398961 attcagcact ggtggcatca aaaatttaaa acgtcgccga aacagacgat attggttgat 1399021 cagattgaaa cgtgcaaaca gatggcgctg cacggaatcg gttatgccat tttgccgtct 1399081 gttacccttc aaaatgaaga taaagtgaat aaaatgcctc ttttagacat gaaagggcat 1399141 ccgatcggtc gggatacatg gttattaggt tatgagcctg cctttgaact gaaacaagtt 1399201 caagcttttg tacaagtgat aaaggatatg ctggatcagg aaaatccatt ttaaagacag 1399261 cgaggtgctg tctttttttt atttatctgt tgacaatgaa aatcattatc atttaaagtg 1399321 atacatatga tattgaaaat cattatcaac taatggggtg ataacatggc taaagccttg 1399381 attacatatg ccagcatgtc aggaaataca gaagacattg ccttcataat aaaagatacg 1399441 cttcaggaat atgagttgga tatcgattgt gtcgagataa atgatatgga tgcgtcttgt 1399501 ttaacctcct atgattatgt actgattggc acctatacat ggggggacgg cgatttgccc 1399561 tacgaagcgg aggatttttt cgaagaggtc aaacagattc agcttaatgg tttaaaaaca 1399621 gcctgcttcg ggtctggcga ttattcttat ccaaagtttt gcgaagcggt gaatttgttc 1399681 aatgtcatgc tgcaagaggc gggagctgct gtttaccagg aaacactaaa aattgaatta 1399741 gcgcctgaaa cagatgaaga tgtggaaagc tgccgagcgt ttgcgagagg ttttcttgca 1399801 tgggcagatt atatgaacaa ggaaaaaatc catgtttcat aaaggggcaa ccgctgttac 1399861 ggcatcggcg ttttctggat attttgtggc ggtacaaaga gaaggcattt ttcattactc 1399921 tttggagcag ggctggagaa agctttttcg tttgaaaagt aagatacact gtatcagcta 1399981 catagggcct tacttatttg gcgttggtga aaagggaaca gtcattcgtt cggctgatga 1400041 agggaaaacc tggacgatgt cgagctttcc gacaaatgca acagtgtggg cgattaccgg 1400101 cagaaacaac gggtttgtct gcgcccacgg taagcattgt atttatgtat cggatgattt 1400161 tggtgtctca tggcgcgtag ccaaaccttt tgccgaattt cataatcccc ctgttatccg 1400221 gtcgttatgc cttcacgggg gcaatctctt tatcggcacg caaatacacg aatattttgg 1400281 cggcatttgg gcttacgaca ttaagcgtga cactgtccaa gttgtcaaaa aagaaaaaaa 1400341 ccggatgacg gcatccatgc tcgtgttcaa tgaaaattgg ctggtggcgg cgatgggttc 1400401 tgtgaaagga aagcacggtg ctgtcactgt aaggaatctt ttgaatggtg aagaattcac 1400461 catacaatcc agtatgatca gaaatgaaga atcatttctt gatctttcag aggatgatgg 1400521 cattatatat gtcactacaa cacaagatga aaatggtttt tcgagaattt accaggttga 1400581 tctcgaagcc cggtcgttaa aatggttcga taccattaag ggacatggat ggagagtggc 1400641 caatcagaaa gagaatttct tttgcgcagg cttgtatgaa tgtaaatttg tccagccgta 1400701 cgaagtttca gcaatgattc attagaggag gaacaaggaa ttggcgaaga ttttgctcgt 1400761 ttatgcaaca atgtcaggca acactgaagc tatggcagat ttgattgaaa aggggcttca 1400821 ggaggcgtta gcagaagtag accgtttcga agcaatggat attgatgatg cccagctgtt 1400881 taccgattat gaccatgtca taatgggaac ctacacgtgg ggagacggag atctgcctga 1400941 tgaattttta gatcttgttg aagacatgga ggagattgat ttttccggca aaacatgcgc 1401001 tgtattcggt tccggtgata cagcatatga atttttctgc ggagcggttg atacgctaga 1401061 ggcaaaaata aaagaacgcg gtggagacat tgtgctgcct tcggtaaaaa tcgaaaataa 1401121 tccagaaggt gaagaagagg aagaattaat aaacttcggg agacaattcg caaagaaaag 1401181 cgggtgcgct gtctgatcac tcactgggaa ctgctaaaac ggctgttcct ttttttcttg 1401241 tctttgtatc tttcctttga tacagtaatg aggtagaaaa tcaggaggag gactatacat 1401301 atgaaaatga tggacgcaaa tgaaattatt tcatttattc aaaatagtac aaaatctaca 1401361 cctgtaaagg tttacgtgaa aggtgagctg gaaggaatca atttcggtga atctgcgaaa 1401421 gcttttatca atggaaacac tggtgtcgtt ttcggtgaat ggagcgaaat ccaaacagca 1401481 atcgaagaaa accaaagcaa aatcgaagac tatgtggttg aaaatgaccg ccgcaattct 1401541 gcgatcccaa tgcttgatct taaaaacatc aaagcgcgta tcgagccggg tgcgatcatc 1401601 cgcgaccaag ttgaaatcgg tgataacgca gtcatcatga tgggtgcttc tattaatatc 1401661 ggttcagtca tcggcgaagg cacaatgatt gatatgaacg ttgtgcttgg cggacgagct 1401721 actgttggaa aaaactgcca tatcggcgcg ggttctgtac ttgcgggcgt tattgagccg 1401781 ccatccgcta aaccggttgt gattgaagac gacgtcgtaa tcggcgcaaa tgctgttgtg 1401841 cttgaaggtg taacagtagg taaaggagct gttgttgctg cgggagcgat cgtggtaaac 1401901 gacgttgagc catacactgt cgttgcaggc acaccagcta aaaaaatcaa agacattgat 1401961 gaaaaaacaa aaggcaaaac tgaaatcaag caggaattac gccagctgta aggaaaagtt 1402021 tgataaaaaa ggcgtggata atatatccac gccttattcg tataggcagg aggaatagaa 1402081 atgaagatag aggagctcat cgcaattcgc agagatctgc atcgtatacc ggagcttgga 1402141 tttcaggagt tcaaaaccca gcagtattta ttaaatgtct tggaacaata tccgcaagac 1402201 agaattgaaa ttgagaaatg gcgaacaggg ctttttgtaa aagtgaacgg gacggcgccg 1402261 gaaaaaatgc tggcatacag agcggatatc gatgcgcttt ctatagaaga gcaaactggt 1402321 cttccattcg catcagagca tcacggcaac atgcacgcct gcggtcacga tttgcatatg 1402381 acaattgcac tcggcattat tgatcatttt gttcaccacc cagtcaaaca tgatttgctt 1402441 tttctgtttc agccggcaga ggaagggcct ggcggtgcgg aaccaatgct tgagagcgat 1402501 gtattaaaaa aatggcagcc tgatttcatc actgcccttc atattgctcc agagcttccg 1402561 gtaggcacca ttgcgacaaa aagcggcctt ctatttgcga atacatcaga gctagtcatc 1402621 gatctggaag gcaaaggggg acatgcggca tatccgcatt tggctgagga tatggttgta 1402681 gcagcaagta cacttgtcac ccagctgcaa acgattatct ctagaaacac agatccgcta 1402741 gacagtgctg ttattacagt tggtaccatt accggaggct cggcacaaaa tatcattgca 1402801 gaaacggccc acctggaagg cacgatccgc acgctttctg aagaatcgat gaaacaagta 1402861 aaggaacgga ttgaagatgt agtgaaagga atcgaaatcg gattccgctg caaaggaaaa 1402921 gtgacatatc cgtctgtata tcaccaagtt tacaatacga gcggattaac agaagaattt 1402981 atgtcttttg ttgctgaaca tcaactggcg acagtaattg aagcaaaaga agcaatgact 1403041 ggagaggatt ttggctatat gctgaaaaaa tatcccggat tcatgttctg gctcggcgct 1403101 gattctgaac atgggcttca tcatgctaag ctgaatcccg atgaaaatgc gatagaaaca 1403161 gcggttcatg tcatgacagg ttatttttct gtttatgcca attaagtaca aatgaaagaa 1403221 taaaattcca taaaatgagc actctagtaa acggaggtgt tcaaaaatgg ctaaaaaaat 1403281 tggaattgaa caatcgttat cagatgtaga agctgcttta aaagaaaaag gatatgacgt 1403341 tgtaatgatg aaaagccctg ctgatgctca aggctgtgac tgctgtgtcg taacaggtct 1403401 tgataataat gtgcaaggga tagccgatac ggtaacacaa gcacctgtca ttacagcttc 1403461 cgggatgacg gctgaagaaa tttgtagcga agttgagagc agaattcagt aataaaaaaa 1403521 ccgaagcaaa aagcttcggt tcttttattt attctgtttc tttagggaaa gcgcggtcga 1403581 acgcgttctt tatttctttt ctcaacactc gttcgactcg ccactgttcc atattttctg 1403641 ttttggcaat gaccctgatt acaatttcag aagtccccag ttcttgaatc ccgatgacat 1403701 ttgggccttc ttttatttgt ggaagagccg ctgccgtttc atcacaaacc tgctgtaaaa 1403761 tatgaatcat ttcatcaata tttctttcag ccggcacttt aatgtcaaca agagcctgca 1403821 tggtaccacg agaatgattg ctcacgtttg tgatgtttct gttggggatg taatgcagtg 1403881 ttccgtcaaa gctgcggatt tgagttgtcc ttaagccaac ctgctcgaca attccgtcaa 1403941 aggtggaaac ggtaatataa tctccgacat ccaattgttt ctcaagcaaa ataaaaaaac 1404001 ctgtcacgat atcactgaca agcccttggg cgccaaatcc gacagccagg ccgacgattc 1404061 ctgcccccgc taaaagagcg cttggatcat aatgaaacaa atctagaacc atgacgaaaa 1404121 atatgaaaat caatgtataa gcaaatatgt taagagtcag gcttcggagc gtatgtgcac 1404181 gtccgataga caagctattc tgctcctcga attttgcaaa cagatgttta atgattttca 1404241 tgcctaatga tcgaacgata aaatagagca atatcataat ggcgagttta atgagcagaa 1404301 caccggcatt tgtaatcagt cccgcccaat catattgttt aataaagtcc atgttgagct 1404361 ccttttctaa ttgattgctg cacattgaga ctagttaccc tgtacatgac catgttaaac 1404421 gttttattca aaaatgtcga agccaaagac atacatgatt tgttaaaaat tgactcagga 1404481 aatctgcttt tatataatgg cattgcaata taactaaaaa tggttaatca ccctttattt 1404541 tcatgcgatt ttgaccttta agccaaacaa taaattggag ggatacatat ggcagaacgt 1404601 atggtaggta aacaagctcc tcgttttgaa atggaagcag tccttgcaag caaagaattc 1404661 ggcaaagtaa gtcttgagga aaacatgaaa aacgacaaat ggacagtgct gttcttctat 1404721 ccaatggact tcacttttgt ttgtccgaca gaaattacag caatgtctga ccgctatgac 1404781 gagttcgaag atcttgatgc agaagtcatc ggggtttcaa ctgataccat ccatactcat 1404841 ttagcttgga tcaatacaga ccgcaaagaa aacggtcttg gccagctgaa atacccgctt 1404901 gctgctgata caaaccatga ggtatcccgg gaatatggcg ttttaatcga agaagaaggt 1404961 gtggctttgc gcggattgtt tattattaat cctgaagggg agcttcaata tcaaactgtt 1405021 ttccataaca acattgggcg tgatgttgat gaaacgcttc gtgttctcca ggcgctgcaa 1405081 actggcggac tctgtccggc taactggaaa ccaggccaaa aaacacttta attctttcca 1405141 agaacgaaaa gcggtctagc atattcgtta ggcctctctt ttaaaatagg agggaaaaag 1405201 caatgaaatt acgtcagccc atgccggaat tgacgggaga aaaagcttgg ttaaatggtg 1405261 aagtgacgag agagcaattg attggggaaa agccgacgct tattcatttc tggtccatca 1405321 gctgccactt gtgcaaagaa gcgatgccgc aagtgaatga atttcgtgat aaatatcaag 1405381 atcagctgaa tgttgtagct gtacacatgc cccgttccga agatgatctt gaccctggta 1405441 aaattaaaga aacagctgct gaacacgata tcactcagcc gatttttgtt gacagtgacc 1405501 atgctttaac cgatgcattt gaaaatgaat atgtacctgc atattatgtg tttgataaaa 1405561 caggacagct ccgtcacttc caagccggcg ggagcggtat gaaaatgctt gaaaaacgtg 1405621 tgaaccgcgt tctggctgaa acggaatagg tatctgacta aatagtattt cctaaaaacc 1405681 tgacctcatc aggtttttta tttgtgcaaa aagcaatgga agaagagtaa gaagcttatt 1405741 tttccaaatt tgggtatagg aattgatgat ttgtttgatt gatacgctaa aaaacacagc 1405801 taatttttga tgtttttcct caattttaga taaatctcat atctcataac tcgaaaattg 1405861 tagatattac actaaatttc tttaaagaag taagtaaaat atatattttc aacattatac 1405921 caaataaact agaaagcccc ttaatccctt gagaataaag gactcttttg aaaaataaaa 1405981 cattttcaga aaataaggaa tttttcatag agtaaatata atagtaaaat gctaaaataa 1406041 tagttgataa aattactttt gtaatctaat atcttaatta aagatgttaa ttttgatagg 1406101 gggtacattg aggaatgttt aatgaaagag aagctttgcg cttgcggtta gaacaattaa 1406161 atgaagctga agtgaaagtc attcgtgaat atcaaattga acgtgataaa atatacgcaa 1406221 aattaagaga gctggacaga aatggaagcc cttccgaaat caaaaaggat ttccgttctg 1406281 aaaaaaaacc tgactctctg ccggttctcg ctgagcttgc ggctcaggaa atcagaagct 1406341 atcagccgca atcacagcag cagtctgttc agcctcagct tcaatctatt tcctctcttc 1406401 ctgccggtat accagacgga acaacacgaa gaagaagagg aacggcaaga ccgggatcaa 1406461 aagcagctaa gctgcgtgaa gctgctatta aaacattaaa acgccacaac gcggcgatta 1406521 agagctcgga gcttcaaaaa gagattgaaa aagaaagcgg tcttgaaatc cctaatatga 1406581 caacgtttat gcaaagctta attaaaatgt acccggaagt gaaaaagcca tatcgcgggc 1406641 agtacatttt agagggtgaa atcgaatctg cagaatcagc aaacgaataa atataaagaa 1406701 aaactgcttg gcatcgctca agcagttttt ttattgaggt tttttctgtg aaggtttgtt 1406761 ttctttttca agattaagct tatacaccca cttttgataa ggcttttctt cagcggctct 1406821 gtttttcagc tcttcgattg tatggctctt ggcctggtct gatgattggg cgtgggcaag 1406881 ctgtttttga agcacatgta tctgtttggt gacatcttca aggatagtct ctacatgatt 1406941 tggctgcgcg taggccgctg gagcttcttc ttccgttttt tctttttgtt tcgtgccgcc 1407001 atcaatatcg gcaaaatgag aagcaatcca ggcatcgctt tcatcaagtt gccgtttata 1407061 cgatataata gtttcgtgaa ataatttttc tttcgttttt tctatgtcta gcagtctttc 1407121 tttcgtttct atgattcgat ctttcatatg atcaacttct attttaatat gttttagctg 1407181 atattctttt tctaccattt gctcttttag acgcccgttt tcggctttta tcaattcggc 1407241 ttgctgtttt gcctgaagca gtgcattttg ttcctgctca attgaggctt gaagttcgct 1407301 gatccgttta tgaagatttt tattttcttc ttcgattttg actttcgcaa tatgaagttt 1407361 atgtttttct tcgatttcgg ctctgcgttt ataggtttca gcagatagaa gctcctgcaa 1407421 aacaacgatt ttatcaagca gttcagctct tatttggtgc agggtttggc tggtgtggga 1407481 ggcatgtttt tcttttgttg acatatgtgt taattcggca gacagctgct ggagtttttc 1407541 tttcatatcg gtattttctt tgagcagttt gttatttttc tgatgaaagt agcttgcttc 1407601 aagttcagaa atcagcttat ggcaccttga aagctcggat tttaaataaa ggttctcctg 1407661 agacacgtcg tggaaaaaag gacctgatct tttcattcga accatctccc tcatgatgtt 1407721 aacactacaa tatgcaaata ctgaacagct attcctcttt aataaacaga caagcagtag 1407781 cgttgagcct ttgcttttgc tatgctttta acgaaactag aggtgagatg atatgaagca 1407841 tgtaaacgta ctgctggcag ggggagcctc acgtcgcttt ggagaaccga aggcgtttgt 1407901 caaatggaag ggcaggatgc tttacgaatg cgctaaagag gcacttggag aacaaacggt 1407961 tatcatcagc cgtcccgaat ttattgatag atttcaagaa aacggtgaaa atgaagtgta 1408021 tcaagatgct gagccatttc aaggcatggg gccattggct ggtatatata ccgcttttaa 1408081 aaagacagac ggtgatcttt atactgttct ttcctgtgac acaccgctga tacaaagaag 1408141 gacgatgctg gagctcaaac gtctgatgat tgccggtgcg gacgcggtag tcccaatttc 1408201 agacggacaa gtgcagccat tgattgcgat ttaccacaaa cgtatcatgc cagttctata 1408261 cgatcagctt tctgagaaga ggttgagaat atcagattta ttaggcagaa tttcggtttg 1408321 ttacgtacag gctgaaaata tcggagcaaa cccggcagag tttatcaaca ttaatacacg 1408381 tgatgatttt agctgtttgg aagaaaaatc gaactccctc aagcgggact gacggggcaa 1408441 taacatgata agatgacata aaagataagg agaacaggtt tgatggagga acgttattca 1408501 cggcaaatca gatttaagca aattggggaa gagggccaga aaagactggc agacagccat 1408561 gtgctgattg tcggagcggg agcgctcggc actgcaggag ctgaagggct ttcgagagcg 1408621 ggagtcggta cgattaccat tattgaccgt gactatgtgg agtggagcaa tcttcaaagg 1408681 cagcagcttt atacagaaag cgatgccaaa ctccgcatgc cgaaagccat ggctgccaaa 1408741 gagcatctat cagcgattaa cagcgagata catattgagg cgtatgttac cgaaggaaca 1408801 gccgaaacgc ttgagccgct gattgaaaaa gcagatgtcg tgatcgacgc gacagataat 1408861 tttgaaaccc gcatgctgat aaacgatctt gcccagaaaa caaagacacc ttgggtctat 1408921 ggcgcctgtg taagcagcca gggaatgttc atgactgtca ttcccggaga aaccccttgt 1408981 ctgtcttgtt tgtttgagca aattcctgtc ggcggggcga cgtgtgatac tgccggcatt 1409041 attccgcctg ctgtgcatat cgtttcagca tatcagcagg ctgaggcatt aaagctgtta 1409101 accggccaaa aagaagcaat acagcggggg tttgtgacat ttgatgtctg gaacaattcg 1409161 catatgaaga ttaacgttaa tcatgtacgc cgtgaggaat gcccatcttg cggagctaat 1409221 gcggtatatc cttatcttca ggattggaac acaccaaaag ctgctgtact atgcggccgt 1409281 gatacagtgc aggtaaggtc agaatcatta aaaagaatcc cgaaacagga gctcattaag 1409341 cggctgaaaa caatcggcaa ggtcgaggct aatgcgtttt tgctgcatat tttttacgag 1409401 gatttcagaa ttgtcatttt caatgacgga cgggcactgg tgcatggaac aaatgatgtg 1409461 aaagaagcca actccgtgtt ggcaagagtg attggactgt aacaacagga ggggtcagaa 1409521 tgctggagaa aagaacaccg ataccggtag acgaggcagt tcggcgtgtc tgccattttc 1409581 aaaaacaagg tgaaacagaa tgggtggcgc ttgaagacag ccttcatcgg tttttagccg 1409641 aagatataac tgcggatcac cacgtacctg cgtttgaccg ttcgccatac gatggttttg 1409701 ctgtcagagc gtgcgatacg gcagaagctt cacgtgaaaa cccagttcgg tttgaagtta 1409761 ttgaccatat tggagcggga gcagtatctg aaaaagaact tggcccgttt caggccgtgc 1409821 ggattatgac tggcgcgcaa atccctgaag gggcagatgc agtcgtcatg attgaactga 1409881 ctcaagcctt tgaggagaat gggaagtcat ttatgtcttt aaaacgccgc tttcagacgg 1409941 gggataatat ttcaaaaaca ggtgaggacg ctcaaaaagg gagtgtttta ctgacaaagg 1410001 gcacccgggt gacaccagga gtgacggctc ttttggcaac attcggatac gcatctgtgc 1410061 ctgtcgtgag aaagcctgta gtcgggatta tcgcaaccgg taccgaattg ctgaatgtca 1410121 gtgatccgct ggaaccggga aaaatccgca acagcaatgc gagtatggta tatgcgcaag 1410181 cgatagaagc aggcgcaaca ccgctttatt tagggaaaat ctctgatgaa ctggataaaa 1410241 gctttgctgc agttaaagaa gcgatgaaaa aggtggactt cctgatcaca actggcggtg 1410301 tgtcagtcgg tgactttgac tttttgcctg cgatctatga aaaactcgga gcggacgtgc 1410361 tgtttaataa agttgccatg cgcccgggca gcgtgacaac ggtggcgcat gcaaacgata 1410421 tgctgctgtt tggcctttca ggtaatccgt cggcatgcta tgtcggtttt gaactgtttg 1410481 tcaaaccgat aatccagaca tggctgctca atgaaacacc gcattcaatt tgtgcggaag 1410541 ctgttttgac caaggatttt ccgaagccga acccatttac ccgatttgtt cgtgcgctcg 1410601 tgcaccatca ggaagggaag ctgttggcga cacccgttgg cttagataag tcgagctctg 1410661 tcacatcact tgcagatgcc aatgcattta ttatcctgcc gggcggtacg cgaggctacg 1410721 aatctggcag aacggttcaa gtgctgctca tcagagaaga gaatggaagt gaatggcctt 1410781 ggtccgtcct ttcccgatcg tccaagttgt aggatttcaa aacagcggga aaacaacgtt 1410841 tattgagcgc attcttgaaa aagcctctga acagggagtc catttgggct gcctgaagca 1410901 ccatggtcac ggcggtgaac cgcaaacgct cacggaagga aaagacacgg accgttacaa 1410961 ggcggcaggt gctgatgtaa cagcggtaga aggtgctggt gtgttacagc tgactgcccg 1411021 ccgcaattgg gatttggcac ggctgattga gttataccaa tttctcgaaa cagactgtct 1411081 tctgattgaa ggctttaaaa aagcccctta tcctaaagtg gttatcctaa gtgaaaagga 1411141 agatctggaa gcgctgcaag cagtaaatat aatcgccatc atctatagaa aaaaagagca 1411201 tatgacagag catcagggat tacccgtttt tcatgcggat gatccggttg ccgtggattt 1411261 tgtgctttca cagctgaagg gggaatctgc ataatggaac ggtttgagat tacgaaaaca 1411321 cccattaata ctgaaaacat catcaaaaaa gtggagaaac gggaagcggg agccattaca 1411381 acatttattg gtacggttcg ggaatggaca aacggaaaaa gaacggttcg gcttgaatat 1411441 gaggcatatg aaccgatggc cgtgcaaatg cttgctcaaa tcggcgctga aatcgaagaa 1411501 aaatgggaag gtgcctcagc tgcgatcacg caccgtatag gtgtgctcga tatcggtgaa 1411561 gcagcggtag tgattgctgt atcttctccc catcgaaaag ccgcatatga agccaatgag 1411621 tatgcgattg aacgcattaa acagattgtg ccgatttgga aaaaagaaat ttgggaagac 1411681 ggtgagcaat ggatcggcga ccagctagaa acgacagctt atccgaacgg aaaaccagac 1411741 ctaagcgagg gagagcagca tgattaaaat tcttttattt gcagggcttg ctgaacaggc 1411801 cggtacacaa gcaatagaaa tagatatgga acaagcaacc acagatgaaa taaaagcgag 1411861 tctaaaagaa caatacggtc ttgaatctat tgatacggct atgattgccg ttaacgaaag 1411921 ctatgtaaaa gaaaatacct ctgtatcttc gggtgacacg gtagccatca taccgccggt 1411981 cagcggggga tgaaaaccgg acggcatttc agccgtccgg tttttctgta tttcattggc 1412041 atatccccaa gtatcctcag catacaatga ttttctgtaa gcgtttattc tacatatgtt 1412101 actccctata aagtaagaga ctcactccat aattagactg aaattttgaa aaataataga 1412161 aatttatttc gggtatcgat atagtgaaga tgataaatgt tggaaaggtg ctggatatgg 1412221 agacatttaa aagattaaaa atgtattatt ggccgtacag aaaagtgttt atgtggtcgc 1412281 ttctagccat gcttttgatg actgcaatta ctgtcgttta tccgattatc ctgcaaatta 1412341 cgattgatga gatcgtactg ggacggcagt atcagcttgc ggcgtgggtc agcttaggat 1412401 ttattgcggt gatggttttg aaaggaatgg ctaccttttt tcatcagtat ttaggtgata 1412461 tgttcgggat caaatccgtt tatcggctga gaaatggtct gtatgaaaaa ctgcagcggc 1412521 tttctttttc ttactatgat aacgcgaaaa caggagattt gatgtccagg ctgactgctg 1412581 atgttgaagg gcttcgtttt ttcttatcat acggtctcgc tgagctcatt cgcttcggcc 1412641 tgctggtagc catcagcctg tcggttatgt tttactattc tgttcctctc acgcttgtga 1412701 caatagctgt tctgccattt ctcgcggttg cggtataccg gtttgacaaa agagtccatc 1412761 ccgccttcag aggcatccgc aaatcgtttg cgaaactcaa tacaaaagtt caggaaaata 1412821 tcagcggcat taatacggtt aaatctcttt ccagggaaga ttttcagatc agcactttca 1412881 ataaagccaa tgcagaatac agggcgcagt atttacaaac atcatccatt tggtctgcgt 1412941 atttcccttt aatggagttc attggtaaca cttgtattgt agctcttctc tcatacggcg 1413001 gttacttggt tatgcaaaat cagctcaatc ccggcgagct tgttgctttc ttcagccttg 1413061 tcaattatat gatgtggccc attatgaact taggttttgt catcaatatg ttctctcaag 1413121 caaaagcgtc aggggaacgc ctgctcgaca ttctggaaaa agaagaagac attacagatc 1413181 atcctcatgc tttgcataaa caaaaattaa ccggagatgt ccatttcaaa aatgtttctc 1413241 ttgcatacgg aaaagaacaa acaaacgcgc tgtgcaatgt aagctttgag gcaaacagcg 1413301 ggaaggtaat cggactgttg ggcccgacag gttcaggcaa aagctcagtg acacagcttc 1413361 tcaccagatt ttacagtcct gttggcggaa tgattaccat tgatcacaaa cccatcacag 1413421 attattcgtt aaaaaccctt cgctccaata tcggggtcgt acttcaagaa tccttcctgt 1413481 tttcatctac gattagatca aatatttcgt atgggcggcc ggatgcctca atggaagacg 1413541 tcatcgaagc ggcaaaaagg gcgcaggctc ataactttat tatggagctt cctgatgggt 1413601 atgacaccat gctgggagag aggggaatgg ggctttccgg cgggcagaaa cagcgtattg 1413661 ccattgcgag agccatctgc ttgaacccga gcattttaat attggatgat gccacaagcg 1413721 cagtagatat gcaaacggag cacagcatac agcttgcctt aaaagaagtc atgaaaaacc 1413781 gcacaacctt tatcgtcgct caccgcattt cttcactgaa acacgctgat gaaattctcg 1413841 tttttaataa aggacgcatt cgtgaaaggg gaacacatca tgagcttctt gaaaaaggcg 1413901 gctactataa aaagatttac gatttgcaat accgtgatgt caaaatgatt aatgagccgc 1413961 atgaggtcgg atagggaggg gccaaatgaa acaagcgaaa aaacaggggg ttttagagcg 1414021 tttctattac tcttcagatg aaatcattga aaagccgttt aactgggctc aaatgtggcg 1414081 gctgctgagc tatgtcaaac catatcgaaa aacaattttg ccgctttctt ttctcactgt 1414141 attgattggc actgctgtga agcttgtgat ccccattttg atcggcgttt atgttcttga 1414201 tcaagcgatt acagggagaa actcggagct gctgattcag ctcattttta ttattagcgg 1414261 tttatatgtc ctcaattacg ccgccaatgt gttaagaatc aggtggatga atcagcttgg 1414321 ccagcatgtc atttacgatt tgcgacagca tttatttacc catgtgcagc gcttatccca 1414381 tcgatttttt gatcagcggt cggcgggatc gatcttagtc aggatcatga atgatattaa 1414441 ctctcttcag gagctcttta caagcggagt catcaatttg ttgaccgact tgctgcttct 1414501 ggccggcgtg attattattt tgtttacgct gagccctgag ctgactatag ccatcatggt 1414561 gacattgccg attatgtttt ttatttcaac aagtctcaga aaaaaaatac gccgatcctg 1414621 gcaaacggta cggctgaagc aatcgaagct caactctcat ctaaacgaaa gcattcaggg 1414681 catccgggtc acgcaggcat ttacgcagga agaagaaaac atggcgtatt ttgacggtgt 1414741 caatcaggag aactacgaat catggcggga agcaactaga aaaaatgcca tgttccgtcc 1414801 gcttgtagaa atgacgaatg cgattgggac ggctgtcttg atttggtatg gagccacact 1414861 catcatgaat gaaaccatta cgattggcgt cttcgtttct tttgctttct atctgggaat 1414921 gttttgggaa cctatttcga gactgggtca ggtctataat cagctgttaa tggggatggc 1414981 atcatcagaa cggatttttg agtttctgga cgaacagcca aatgtcaagg agaagccgaa 1415041 tgccattcat aatgaaaaga taaatgggga gatcagtttt gaagaggttg aattttcgta 1415101 tgatgaaaaa cgaaaagccc ttcacgccgt ttctttctct attcctgcgg gatcgacgct 1415161 tgcgcttgtc gggcatacag ggagcgggaa gacgacgatt gccaatttaa tcagccgttt 1415221 ttatgatgcg gccggaggca ccattaaaat agacggtata ccgattaagg atctttccct 1415281 tgccagtctg cgctctcaaa tcagcattgt cctgcaagat acatttattt tctccgggac 1415341 catcatggaa aatattcgtt ttggaaggcc aaatgcttcg gatgaagagg tgatgaaagc 1415401 gtcccaagcg gtcggagcgg atgagtttat ttccgattta gcggaaggat acgcaacaga 1415461 ggtagaggaa aggggcagcg tactgtctgc cggtcagcgc cagctcattt catttgcaag 1415521 agcattgctc gccgatccgg ctattatcat ccttgacgaa gcaacggcaa gcattgatac 1415581 agagacagaa gtaaaaattc agcaagcgtt aaaaacgctt ctgaaagggc gtacagcagt 1415641 gatgatcgct cacagattgt ctacgatccg cgacgccgac cgcatcattg ttcttgatca 1415701 cggcaggaaa atagaagaag ggaaccatga tcagctgctc gctaaaggag gcatttatgc 1415761 cgggcttgtg aaagcgcaat acagcacagc gatagaataa tatgaaaagc cttcaatatt 1415821 gaaggttttt ggaaatttat tagaaaaaca tgaaactttt tgatatcctt cccgtactat 1415881 ttgttagata ttctcaagga ggttttgaaa tggaaacgaa tgtagaaaaa aacagcggaa 1415941 cggcgactga aaagccttca cttttcggag taatcacaag tccgtccgtt caatttgaaa 1416001 gaataagaga aaggccggct gtatggggac cgcttttgat tgttgcagca attatcatcg 1416061 tcggtgccgt gctgcaatca ctcggtacgg attatagtga gcttttgaaa agccaggata 1416121 cgcaagggct atctgctgaa caaatggaaa ctgtcgcaac aataaccaaa tttggcggaa 1416181 tggcaggcgc tattatcggc ggtatcgcag cattatttat tgcccctctt atttattggc 1416241 tctgtgtaaa agtatcaggc ggtgttacga catataaaaa aatgctttct ctcagtctgt 1416301 ttgtctcttt gattagcagt ctcggattat tggttaatgg aatcgttgct tttacgactg 1416361 acgtgaatcc tctttacagc acgacgtcac tcgcagggat tatcccatct gacggggctc 1416421 tcgccagtgt gttaaatacc tttgaaattt tcagcatctg gagctttgta ttattagcaa 1416481 tcggacttca caaaacggga ggcatctcaa aaaaagccgg gtggatttca gcaatcattc 1416541 tattcggaat tttagttgta ttttcgcttt tttcaggttt aatcaattct gtggcgggtg 1416601 cataagctca tgaaaaaagt ctggatcgga attggaatcg cagttatagt cgctcttttt 1416661 gttggaatca atatataccg gtctgccgct ccgacaagcg gcagcgccgg caaggaggta 1416721 cagacgggga gcgttgaaga aaatgaaatc tcatcaacgg ttatggttcc tggcacgcta 1416781 aaattttcaa atgaacagta tgtcttttat gaagcggata aagggacatt agaagacatt 1416841 aaagtaaagg aaggcgataa agttaaaaag ggcacggctt tagtcaccta tacaaatgag 1416901 cagctgagcc tggaaaaaga acagaaccag ttaacgtctg aatccaaccg gcttcaaatt 1416961 gaccaaattc aagaaaagtt aaaagccttg gacagcaaag aaagagaact ggaaaaacag 1417021 gtaggaaaga aagaagcaga aaaacaaatc gaatctgaac ggacagagct tcaaatgcag 1417081 aaaaaaacag cggagatcga attaaaacaa accgagcttc agcggcagtc acttgccaac 1417141 cgggtgtcag atttagaagt gaaaagcgaa attgaaggca ccgttatttc tgtcaaccaa 1417201 gaagcggcat ccaaaaagtc agatattcaa gagcctgtca tacatatcgg caacccaaaa 1417261 gaccttgtcg tctcagggaa attgtctgaa tacgatacat tgaaagtcaa aaaaggccag 1417321 aaggtcacac tcacttcaga tgtaatacag ggtaaaacat ggaaaggcac ggtttccgca 1417381 gtcgggcttg ttccggatca gcaggagagc gctgcggcac aaggaacaga acaggcggtc 1417441 caatacccgc ttcaagtgaa aataaaagga aatcttccag aaggaaagcc aggctttaaa 1417501 tttatcatga atattgaaac agataaacgg aaagcaaata cgcttccttc aaaggcagtc 1417561 aaaaaagaag atgaccaata ttatgtgtat acagtaaaag acggaaaagc aaagcgagtt 1417621 gatgtcaaaa tcggcgaagt gacagatgac ctgacagaaa ttaaagaggg gcttacccaa 1417681 gatgatcaag tcattttgaa tccatctgat caggtgactg acggaatgga agtgaaatcc 1417741 taaatgattc agctttctaa tgtgcgaaaa agctaccaga tcggaaagga aacgtttgat 1417801 gttctccatt ctattgattt ggacattcat caaggtgaat atgtctcgat tatggggccg 1417861 tcaggatcag gaaaatcgac gatcatgaat attatcggct gtcttgatcg gccgacttcc 1417921 ggtacatatc aattggacgg cgaagacatt tcttcatata aagataaaga actggcggca 1417981 gtccgtaacc ggtccatcgg ttttgtattt cagcaatttc agcttcttcc gcggctgaac 1418041 gcaaaaaaaa atgtcgagct gccgatgatt tattccggga taggcaaaaa ggaacgtcaa 1418101 gagcgggctg agagagcatt ggaaaaggtc gggttagccg atcgaatgct ccacatgccc 1418161 aacgagctgt cgggcgggca gaagcagcgg gtggcgattg cgagggcgat cgtgaatgag 1418221 ccgaaattga ttttagctga tgaaccgacc ggcgcgctgg atacgaaaac aagcgaggcg 1418281 attatggatc agtttacagc attaaatgcc gagggaacga caatcgttct ggttactcac 1418341 gagcctgaag tagcagattg cacgaatcgg atcgtcatgg tgcgtgacgg aaacattgtt 1418401 cctgccagct ccggacaaag gagtgtggga gaatgagcct gttggaaaac atcagaatgg 1418461 ctctaagctc tgtccttgcc cataaaatgc gttcgatctt aacgatgctc ggcattatca 1418521 ttggtgtagg ctctgtcatt gttgtcgttg cggtaggaca gggcggcgag caaatgctga 1418581 agcagtcgat cagcggcccg ggaaatactg tggagctgta ctatatgcct agcgacgagg 1418641 agcttgcaag caacccgaat gccgcagctg aatctacgtt tacagaaaac gatattaaag 1418701 gtttaaaagg aatagaaggc attaaacaag tcgttgcttc gacttctgaa agtatgaaag 1418761 cgcgttatca cgaagaagaa accgatgcta cggttaacgg aataaatgat ggatacatga 1418821 atgtcaattc tttgaaaatc gaaagcggca gaacctttac cgacaatgac tttctcgcgg 1418881 ggaatagagt cggaatcatc tctcaaaaaa tggctaaaga gctgtttgat aaaacctccc 1418941 ctctaggtga agttgtctgg attaacggac agcccgttga aattatcggc gtgctgaaaa 1419001 aagtaacagg cttgctttct ttcgatttaa gtgaaatgta tgtgccattt aatatgatga 1419061 aatcctcttt tggcacaagt gatttcagta acgtatcatt gcaggtcgaa tcagcagacg 1419121 acataaaatc ggctggaaaa gaagcggcac agctggtaaa tgacaatcat ggcacagagg 1419181 attcgtatca agtgatgaac atggaagaga ttgcggccgg aattggcaaa gtaactgcaa 1419241 ttatgacgac gattatcggc tcaattgcag gtatttccct tttggtcggc ggaatcggtg 1419301 tcatgaatat tatgctcgta tcagtcacag aacggacgcg ggaaatcgga atcagaaaat 1419361 cacttggtgc gacgagggga cagattctga ctcagttttt aattgaatca gtcgtattga 1419421 cgctgattgg cggtctggtc gggattggta ttggatacgg aggggccgcg cttgtttcag 1419481 ccattgcggg ctggccgtca ctcatatcct ggcaggttgt atgcgggggc gtgctgttca 1419541 gtatgctcat tggtgttatt ttcggcatgc ttcctgcaaa taaagccgca aagcttgatc 1419601 ccattgaagc gctgcgttat gagtagcctc atgcaacatg catgaggttt ttttatgttt 1419661 agtgatttct actatgaata taaaagactt ttttcattaa aataagaaga aaatgtcgta 1419721 caattgtcct tatttttgtc gaatttacag tttacaaacc ctatagacat acgttaatat 1419781 ggagaaacgt gaaagatttt gatagttatt gaatgaattt gaatgatttt agttgcctaa 1419841 accgaaaata gcgtttacaa tgaaattgta ttcaaaatga atacgttttc attaggaggt 1419901 gaagcatgct aactcctgaa cggcatcaat tgattattga tcaaatagaa aagcatgatg 1419961 tggtaaagat tcaagagctt ataaatctga ctaatgcttc tgaatcaaca atcagaagag 1420021 atttatcgac ccttgaagaa cgcggttttt taaagcgcgt tcatggtgga gcggccaagc 1420081 tttccgatat cagacttgaa cccgatatgc ttgaaaaatc atccaaaaac cttcacgata 1420141 aactgaagat tgctgaaaaa gctgcttctc ttttagaaga aggggattgc atttaccttg 1420201 atgcaggcac gacgacattg cacatgattg attttatgga taaaaccaaa gatattgtcg 1420261 ttgtcacaaa cggggtaatg catatcgatg cattaataag gaaagaaatt tctttttatc 1420321 tgcttggagg atacgtaaag cacagaacgg gcgcgattat tggaggcgct tcattggttg 1420381 ccatggacca gtacagattt gacaagagtt ttctggggac aaacggtgtc catacagagg 1420441 ctggatttac aacgccggac cctgatgagg cccttttaaa acagaaagcg atcaaacagg 1420501 caaaacacgc ttacgtctta gcagaccctt cgaagttcgg agaaatttca ttttcggcat 1420561 tcgccggaat aggcgacgca acaatcatta cgactgacgc tgaagagctt acattcgata 1420621 attaccaaga aaaaactgtc gtaaaggtag tgaaaccatg atttacactg taacacttaa 1420681 tccatctgtc gattatatag ttcacgttga agattttact gtaggaggcc tgaaccgttc 1420741 ttcgtatgat accaagtatc cagggggcaa aggcatcaac gtatcgagac tgctgaaaag 1420801 acaccatgtg gcgtctaaag cgctcggatt cgtcggcgga tttaccggag aatatatcaa 1420861 aacattttta cgggaagaaa acctggaaac agctttttct gaagtaaaag gggatacccg 1420921 tatcaatgta aagctgaaaa cgggtgatga aactgaaatt aacgggcagg gaccgacaat 1420981 ttcggatgaa gatttcaaag cctttttaga acagttccaa tctttgcaag agggagatat 1421041 cgttgttctt gcaggaagca ttccatcttc actccctcac gatacttatg aaaaaatcgc 1421101 agaggcctgc aaacagcaga acgcacgagt tgttctggat atctcaggcg aggctctttt 1421161 gaaagcaaca gaaatgaaac catttttgat gaagccaaat catcatgagc ttggagaaat 1421221 gttcggcacg gccattacat ctgttgagga agccgttcct tatgggaaaa agcttgtaga 1421281 acaaggcgct gaacatgtaa tcgtatcaat ggccggagac ggagcgcttc tgtttacgaa 1421341 cgaagctgtt tattttgcta acgtgccaaa ggggaaattg gtaaactcag tcggagcagg 1421401 ggattccgtt gttgcaggtt tccttgccgg aatttccaaa cagctgccgc ttgaagaagc 1421461 attccgctta ggagttactt caggcagtgc taccgcgttc tctgaagaac ttggaacaga 1421521 agaatttgtc cagcagcttc ttcctgaagt taaggtcaca cgtctataga ggaggaaaca 1421581 caagtgaaaa taactgagct tttaacgaag catacgataa agcttaatat tgagagcaaa 1421641 gaaaaagaaa atgttattga cgaaatggtc actgttcttg ataaggctgg aaagttaaat 1421701 gaccgacaag cctataaaga agccatttta aatcgcgaaa gccaaagctc cacgggtatc 1421761 ggtgaaggaa tcgctatccc ccatgcgaaa acggcaagcg ttatcaaccc ggcgatcgcg 1421821 ttcggacgtt caaaagacgg cgtcgattat gaatcattag acggccagcc ggctcactta 1421881 gtgttcatga tcgcggcgac tgaaggcgca aacaacactc accttgaagc attgtcaaga 1421941 ctttcaacgc tgttaatgcg tgaagaaatc cgtaagcagc tccttgaagc tgagtctgaa 1422001 gatgccatca tcgacattat taatcagcac gataaagatg atgacgaaga ggaagaggaa 1422061 gaagaagcgg caccagcacc tgccggaaaa gggaaaattt tagcggttac tgcatgcccg 1422121 acaggtattg cccatacatt catggctgcg gatgccctta aagaaaaagc gaaagagctt 1422181 ggtgtggaaa ttaaggtcga aacaaatggg tcaagcggca ttaagcacaa gctcactgcc 1422241 caagaaatcg aagatgcacc tgcaatcatt gtcgcagcgg acaagcaggt tgaaatggaa 1422301 cgttttaaag gcaagcgcgt acttcaagtt cctgtaacgg cgggtatcag acgtccgcaa 1422361 gagcttatcg aaaaagcgat gaatcaagat gcgccgattt atcaaggcag cggcggcggt 1422421 tcagcagctt caaatgatga tgaagaagcg aaaggcaagt ctggaagcgg tatcggaaac 1422481 acgttttata agcacctgat gagcggtgtc agcaacatgc ttccgttcgt agtcggcggc 1422541 ggtattctcg ttgcgatttc attcttctgg ggaattcact ctgctgatcc gaatgatcct 1422601 agctacaaca cgtttgcagc agcattaaac tttatcggcg gcgacaatgc attaaaactc 1422661 attgttgcag ttctggccgg tttcattgcg atgagtattg cagatcgtcc tggttttgcg 1422721 cctggtatgg tcggcggatt tatggcaact caagcgaatg ctggattctt aggcggctta 1422781 attgccggat tccttgccgg ttatgtcgtg attttactga aaaaagtatt tacgtttatc 1422841 cctcagtcac ttgatggatt aaaacctgtt ttgatttacc cgctgttcgg tatttttatc 1422901 actggcgtat taatgcaatt tgtcgtcaat acacctgtag cggcatttat gaatttctta 1422961 acaaactggc ttgaaagcct tggtactgga aaccttgtgt taatgggtat tatcttgggc 1423021 ggcatgatgg cgatcgatat gggcggtccg cttaataaag cagcctttac gttcggtatc 1423081 gccatgatcg atgcaggcaa ctatgcgcct catgcagcaa tcatggccgg cggtatggtt 1423141 cctccgcttg gtatcgcact tgcaacaacc attttcagaa acaaattcac tcagcgtgac 1423201 cgtgaagctg gtattacatg ctatttcatg ggagctgctt tcgtaacaga gggagcgatc 1423261 ccatttgctg cggctgatcc gcttcgcgtc ataccagctg ctgtagtcgg tgcagctgtt 1423321 gccggcggat taactgaatt cttccgagta acgcttccgg cgcctcatgg aggagtattc 1423381 gtagctttca ttacaaacca tccgatgctt taccttttaa gtatcgtgat cggtgctgtc 1423441 gtgatggcaa ttatcctcgg tatcgtcaaa aaacctgtta cagaaaaata agaaaaaaag 1423501 cgtccttggt tcgaaaggac gctttttctt atccggccgg cagggagcgc ggttaagtta 1423561 tgtattttat tcttttttat gataaagtaa aagaagagaa acaactgaca tagcaattgt 1423621 ctaggaggaa acactttgac cgaggaaaaa aatacgaata ctgagaaaac ggcgaagaaa 1423681 aaaaccaata cgtacctgga atggggtaaa gcgattgtca tcgctgttct gctggctctc 1423741 ctgatccgtc actttttgtt tgaaccgtat ttagttgaag gttcatctat gtatcccaca 1423801 ttacatgacg gagaaaggct gtttgtgaat aaaacagtca actatatcgg cgagctgaag 1423861 cgcggagata tcgttattat caacggtgaa acttctaaaa tccattatgt aaaaagattg 1423921 atcggaaagc ctggagaaac cgttcaaatg aaggatgaca cgctttatat aaacggtaaa 1423981 aaagtagccg agccttactt gtctaaaaac aagaaggaag cagaaaaact tggtgtcagt 1424041 ctgacaggag actttggacc ggttaaggtt ccgaaaggca aatactttgt catgggagat 1424101 aaccggctga attctatgga cagccgaaac gggctgggac tgatcgcgga agatcgaatt 1424161 gtcggcacat cgaagtttgt ctttttcccg tttaacgaaa tgcgtcaaac aaaataaaaa 1424221 cgccttgctg gcctaggaca gcaggcgttt ttattttgaa aaagaagcga ccaatgcaat 1424281 gcataaaacc gtgatgaaca ctgaaccgat aatagccagc acactgaaga aaaggtgaac 1424341 ctgtttgttc tcttttccgc gcttttctaa tagccgttta gaaaaaatgt gcgaaaatat 1424401 gtaaataagg gctatgccta tatataagcc gatatctttg gcggtaaagc ctgttacggc 1424461 aaggtaaaag cccgtaaaaa agatcagtaa gcaatattca gtaagtgtta aaagcctcaa 1424521 cgtgttcctc catgagagtg tgtaattttc caggcggatg cattctctct ctttaattgt 1424581 aacacagctg gctggtttgg gtgtataagt gttttctctc tgttttatca gggaatcatt 1424641 tctcttgccc tgcattcatg gtatactttt attgatgata gacatgatgg aggataataa 1424701 atgattgctg taaataatgt aagcttgcgg tttgcggatc gcaagttatt tgaagatgtt 1424761 aatattaaat ttaccccagg caactgctat gggttaattg gtgcaaacgg tgccggtaaa 1424821 tcaacgtttc taaaggtgct gtcaggcgaa atcgagcctc agacaggcga cgtgcatatg 1424881 agtcctggcg agcgtcttgc cgtcttgaag cagaaccatt ttgagtacga agagtatgaa 1424941 gtgctgaaag tggtcattat gggccacaaa cgcctgtatg aagtcatgca ggagaaagac 1425001 gctatttaca tgaagcctga tttctcagat gaggatggga ttcgtgctgc tgagctagaa 1425061 ggtgaattcg cggaactgaa cggttgggaa gcggaaagtg aagctgcgat cctgttaaaa 1425121 ggccttggta tctcagaaga tctgcacaca aaaaagatgg cagacctcgg cggttcggag 1425181 aaggtaaaag ttctcttggc acaggcatta ttcggcaagc cggatgttct gctgctcgat 1425241 gagccgacga accacctgga ccttcaggca attcagtggc ttgaagagtt tctgattaac 1425301 tttgaaaaca cagttattgt cgtatcccat gaccgtcact ttttaaataa agtatgtacg 1425361 cacattgccg accttgattt taacaaaatt caaatctatg tcggaaacta tgatttctgg 1425421 tacgagtcaa gccagctggc gttaaagctt tctcaagaag cgaacaagaa aaaagaagag 1425481 cagattaaac agcttcaaga gtttgtcgct agattcagcg ccaatgcgtc taaatctaag 1425541 caggctacat caagaaagaa acttctcgaa aaaatcacgc tggatgatat taaaccgtct 1425601 tcccgccgct atccttatgt taacttcacg ccggaacggg aaatcggaaa tgatgttctt 1425661 cgcgtggaag gcttaacaaa aacaatcgat ggcgtaaagg tgcttgacaa tgtcagcttt 1425721 attatgaatc gagaagataa aattgctttc actggccgaa atgaacttgc tgttactacg 1425781 ctgtttaaaa tcatttccgg ggaaatggaa gctgacagcg gaacgtttaa atggggtgtt 1425841 accacatctc aagcgtattt tccaaaagac aacagcgaat atttcgaagg cagtgatctg 1425901 aaccttgtag actggcttcg ccaatattct ccgcacgacc aaagtgagag ctttttacgc 1425961 ggtttcttag gacgcatgct gttctctgga gaagaagtcc acaaaaaagc aaatgtactt 1426021 tccgggggag aaaaggtccg ctgtatgctg tcgaaagcga tgctttctgg cgccaatatt 1426081 ttaattttgg atgagccgac caaccattta gacctagagt ccattacagc gctcaataac 1426141 ggcttaatca gctttaaagg cgctatgctg tttacttccc atgaccatca gtttgtgcag 1426201 accattgcca acagaattat agaaattaca cctaacggca tcgtcgataa gcaaatgagc 1426261 tatgacgagt tccttgaaaa tgctgatgtg cagaaaaaat tgactgaact atacgccgaa 1426321 taaaaaagca gagatttctc tgcttttttt gatacctaaa tgtgaaagga gatcacaaca 1426381 tgaaattttt ggttgtcgga gcaggtggag taggcgggta tattggcgga cggctttcgg 1426441 agaaaggaaa tgatgtgaca tttctcgtgc gccaaaaacg agctgagcag cttaaaaaaa 1426501 ccgggcttgt catccatagt gaaaaaggga atgtatcatt tcagcccgaa ctaatcagtg 1426561 ccggagaaac agggcaattt gatgtcgtta tcattgcttc taaagcatac tcgcttggtc 1426621 aagtgataga ggatgtcaaa ccatttatcc atcaagaatc tgtcattatc ccttttttaa 1426681 atgggtaccg ccactatgag cagctatttg cggcattttc aaaagaacag gtgctgggcg 1426741 gcctgtgttt tatagaaagt gctttagaca acaaaggaga aattcatcat acgagcgcat 1426801 cgcatcgttt tgtatttgga gaatggaacg gcgagcgtac ggagcggata agagcgcttg 1426861 aagaggcatt ttcaggtgtg aaggctgaag tcatcattag cgggcatatc gagaaggaca 1426921 tttggaaaaa gtatctcttt attgcagcgc aagcggggat cacaacgtta tttcaacgac 1426981 cgcttggccc aatcctcgcc acagaagccg gacgtcacac ggcccaaact cttattgggg 1427041 aaatttgcac tgttttacga aaagaaggtg ttccggctga tccggctctt gaggaagaga 1427101 gctttcgtac gatgaccagc atgtcttacc atatgaagtc ctccatgctt cgggatatgg 1427161 aaaacggcca aacgacagaa ggcgaccacc tgcatggatt tttgattgaa aaagcaaaac 1427221 gtttatctct cgctgcacca gtattagaaa ccgtttatgc gaatctgcaa atgtatgaag 1427281 cagaaaaata aaaaaaggag gcggaaaagc ctccttttat ttacttaaaa agcccaattt 1427341 ccgtttctga agataggctc tcttttcccg tctgccgtaa ttccgtcaat attcatatcc 1427401 ttagaaccga tcataaagtc cacgtgtgta atgctttcat ttaggccttc tttgacaagc 1427461 tcttcacgag acatctgctt tccgccttca atattaaagg cataggcgct tccgatcgcc 1427521 aaatgatttg acgcgttttc atcaaacagc gtgttataga aaagaatgtt tgattgtgat 1427581 ataggcgaat cgtaaggaac aagtgccact tcacctaaat agtgagaacc ttcatctgtt 1427641 tccaccagtt cttttaaaat atcctcacct ttttcagctt taatgtcgac tatacggcca 1427701 ttttcaaacg tcagggtgaa attttcaata atatttccgc cgtagcttaa tggttttgtg 1427761 cttgatacca ctccgtcaac cccgtctttt tgcggcagcg tgaacacttc ttctgtcggc 1427821 atattggcca taaactcatg gccactttca ttcacgcttc ccgcacctgc ccaaacatgc 1427881 ttcctaggca gcttaattgt tagatcagtt ccttctgctt gataatgtaa ggcagcgtaa 1427941 tgtctctcgt tcaaatggtc aactttttca tgaagatttt ggtcatgatt gatccacgcc 1428001 tgaaccgggt tgtcttcatt tacgcgcgtc gctttaaaaa tttcttccca cagaaggtgg 1428061 atcgcttcct cctctgattt gccaggaaac accttgtgag cccagcctgc tgatgccgca 1428121 cctacgacag tccagctgac tttgtctgat tgaatatatt gtctgtatgt atgtaatgct 1428181 ttgcctgctg ctttttggaa tgccgcaatc cgtttggaat ctataccttt tagcaagtct 1428241 gggttcgacg acacaacaga aatgaaagca gctccatttt tggcaagctc ttctctgcct 1428301 tttgcttccc attcaggata ttcttcaaat gcttcaaacg gcgcaagttc gtattttaat 1428361 ttggcgactt cgtcatcctg ccaattcacg gtgacgtttt ttgcgccctt ttcatatgcg 1428421 tgttttacaa ttaaacggac aaaatcccga acgtctgttg aagcatttac gactacatac 1428481 tggccttttt ggacattaac gccgacttct accgccagct gtgcatatgt atttaatttc 1428541 tgtgaaaatg aatccatgaa tcattcctcc aagctttttt ctcatcatat caaatatgat 1428601 cctataaagg aaagaaggag cccaaagtga aaaacccaaa acgacacgtc ttgggttttt 1428661 tcaatattat ggatgattca gttttacagt gccgcctgca ggcgaatggg gcatatttgc 1428721 caaagaaatg ctcatgcctc caagaataat tccgcttaaa atggctgcga tcgctactct 1428781 tcttcctaaa tctcttagca tctgtttcct ccttaacgtt tctccatttc ccacaatatg 1428841 aaggaagtga ggaaaaaaga agcaagaaat ttgccgcgtg tgagaatttt gcgggtaaag 1428901 actatttaat tgccttttgc agcttatcaa tcacttctaa agaacggcct gtgccgattg 1428961 ctacagattc aagcgggttt tgcgccacgt gtacaggcac gacaatctct tctgtgagcc 1429021 attctttaat tccattaagg agcgcgccgc cgcctgttaa aataacgccg cgatcaacaa 1429081 tatctccgct caattcaggc ggacagtcct caagtgtcgc tctgatggct tcaagaatat 1429141 gcaggaggga ttcacgcatt gcatcttgaa tttcgttgga ttgaagcata atggtttttg 1429201 gaagacctgt cacgaggtca cgtccccgaa tttccattgc ctctggtata tgttcaatca 1429261 gagcatggcc aatttccatt tttacctgct cagctgtgcg ttcgccgatc agcaaattgt 1429321 attttttacg gacgaaagaa acgatatcct catcaagctg gtctccgccg atcctgatag 1429381 aatggcagga aacaacgcca ccgaaggaaa taatagcgac ctctgtcgtc cctccgccga 1429441 tatctactac cacattggca accggctcat caaccggtaa atccgctccg atggcggctg 1429501 caactggctc ttcgattaaa tgaacgtttt tcgcgccgca atttttcacc gcatcactga 1429561 tggcgcggcg ttctactgct gttgagcctg atggtgtgca aacgactacg ttcggttttc 1429621 tgaacgacat gccgatgctt tttgcggctt ttttcataat gtgctttagc aggtcagttg 1429681 tcatatcata gtctgcgatc acgccatctt tcatcggtct gacagcgaca atttttcccg 1429741 gtgttttacc gatcatgttt ttcgcgtcag ctccgattgc aagcactgct tttgtcgtcg 1429801 tatccactgc gacaacagat ggttcattta ggataatccc tttatttttg ctgtaaacaa 1429861 gtatattagc tgttcctaag tcaatcccga tttcagttga ttgaaacatg ttttcaccca 1429921 atctctatcc taatttaata tgattctaca tttaaagttt ctcagaaata ctgcgatttt 1429981 tgggggtgtg cgtcggtaaa gaaatgtttt tgtaaaaaat caaggaactg tgtaacagaa 1430041 gtaatacatt tttcggtttt atggaaaaaa tatcttgtaa ttcttataga aagcgggaaa 1430101 ctttttcaaa gtttcattcg tctacgatat attgaggtac atccttaaaa cattacatga 1430161 gaaaagaaac atttaaagga agaagggttt ttatgaaatc aataggtgtt gtgagaaaag 1430221 tagatgaatt aggccgcatt gtcatgccga ttgagttgag acgggcattg gatattgcca 1430281 taaaagacag cattgagttt tttgttgacg gagataaaat tatcttgaaa aagtacaaac 1430341 ctcatggcgt ttgtttaatg actggagaaa tcacttcaga aaataaagaa tacggcaacg 1430401 gtaaaattac gctaagccct gagggtgcac agctgcttct cgaagaaatt caagccgctt 1430461 taaaagaata aaattatgct aaaaaaggcg gagtgatatc atctccgcct tttttgcgtg 1430521 ccaatttttg attaccgccg cctaagataa gacatcaaga tatttggtaa tgaatgattt 1430581 gggatacttt acatatttta ctcaattatt tgtcgaagaa tggtacaata agtagagaaa 1430641 cacaagcggc aggtggtcat atgagaaaat atcaagctcg tatcatttcc atcattttgg 1430701 caatgatttt tataatgttt tgggattatt tattttattt tataggcaaa aacccgatta 1430761 attggcctgt tgatattgtg tatactgcag tcacgctggt aagtgtctgg atgttggctt 1430821 attatattga tgagaaacag cagctggtta agaaaatgaa ggataacgaa tggaagtata 1430881 aacagctttc tgaagaaaaa aaccgcatca tggataattt gcaggaaatc gtatttcaaa 1430941 cgaatgcaaa aggtgaaatt acatatttaa accaagcgtg ggcatctata accgggtttt 1431001 caatcagtga atgtatggga acaatgtata acgattactt cataaaagaa aagcacgtag 1431061 ccgaccacat taacacccaa atccaaaaca aagcgtcttc tggcatgttt acggcaaaat 1431121 acgtgacaaa aaacggcacg attttttggg gagaagttca ttataaactt tactatgacc 1431181 gggatgacca atttacaggc agcctgggta caatgtcaga tatcactgag cggaaagagg 1431241 ctgaagatga gctcattgag attaatgaac ggctggcgag ggaatcccag aaactatcaa 1431301 tcacaagtga acttgccgca ggtattgctc atgaggtcag aaacccttta acatctgtca 1431361 gcggtttcct ccagattatg aaaacacaat atccggacag aaaagactat tttgacatca 1431421 tcttttcaga gattaaaaga atcgatttag tgctcagcga gctgctgctg cttgcaaaac 1431481 cgcaggcaat cacatttaaa acacaccagc ttaatgagat cttgaaacaa gtcacgacat 1431541 tgcttgatac caatgcaatt ctgtccaata tcgtcataga gaaaaatttc aaagagacag 1431601 atggctgtat gattaatgga gacgaaaatc agctgaagca ggtctttatc aacatcatta 1431661 aaaacggaat tgaggcaatg ccaaagggcg gtgtcgtaac catttcaact gctaaaaccg 1431721 cctctcatgc agtgataagc gtaaaggatg aaggaaacgg catgccgcag gaaaagctga 1431781 agcagattgg caaacctttt tattcaacaa aagaaaaggg cactggactg ggacttccca 1431841 tttgtttgag aatcctgaag gaacatgacg gggaattgaa aatcgaaagt gaagctggaa 1431901 aaggcagcgt ctttcaagtg gttttgcctt taaaatcaga cagctgagag gagaaaaata 1431961 aagtgaactc gcttctgttt gtatacggga cattaagaaa gcatgaaaaa aaccatcatt 1432021 tgctggcaca atcggcatgt atcaatgagc aggcgagaac aaagggaagt ttgtttgctg 1432081 caaaagaggg gcccacagtt gttttcaatg atgaagatga aggctatata tatggcgaag 1432141 tatatgaagc agatgaattg tgtatacata agctcgatca attttttcaa ggatatcata 1432201 aacaaacggt gtttgtagaa acggatgtcg ggattaaaat tgcgcttatt tattttatga 1432261 acaaagacgg gtgtgccggt tttacgaaaa taagcagcgg cgactggaaa gaacatcaga 1432321 tgatcagcaa atcgaaaaat cccatttatt attttgccta tggatcatgc atggataatg 1432381 cccgctttca aaaagcggga gtcgatcact attttcaaga tccagtagga agagctgttt 1432441 taaaaggata cacaacccgc ttcacgctaa aaagggaaga cggttcaaga gcggacatgt 1432501 tggaagacgg aggaacaaca gaaggcgttt tataccgtat cccttattct gctctctcct 1432561 atctatataa aagggagggc gtcgaatctc ttacgtatcg gccggcattt gtagacgttg 1432621 aagctggcgg aaggcactac aaagactgtt taacctttct cgtcctccaa aaagaagcgg 1432681 aaattgcccc gcctcagcac tatcagattg aaatcgaacg cggagcggag ctgtatttgt 1432741 cgcctgagtt tactgaaaag ctcaagcggc atatgaattc gctgccaaaa ggataacact 1432801 gtaacaaaag aatatgataa aatttgatca atatcatgtc atataaagga gcaccacgat 1432861 gaaaaaagaa tttgcggtaa ttgggctggg ccgttttggt ggcagtattt gcaaagcatt 1432921 aagcgaagaa ggcgtcgagg ttatggcaat ggatatcgat gaagataaag tcaacgagta 1432981 tgccaagatt gcatctcacg cagttatcgg tgattcgaca gacgaatctg tcctgaaaaa 1433041 tttaggcctg cgaaattttg accacgttat tgtagcaatc ggggaaaata ttcaagcgag 1433101 tattttaacg acactcattc tgaaagaact tggcgtccat acgattacag ttaaagcgca 1433161 gaacgattat cacgaaaaag tgctgtctaa aattggtgcg gatcacatcg tccacccgga 1433221 acgcgatatg gcaaaacgaa ttgcgcataa tatcgtgtcc aacaatgtac ttgactattt 1433281 ggagctgtct gaagagcata gtcttgttga aatcgtagct aacagccgcc tggctggaaa 1433341 tacgcttctc gatttagata ttcgcgcaaa atacggtatt aacatcgtag ccataaaaag 1433401 gggcaaggaa gtcatcgtat caccgcttgc aaccgaagtc atccaccaag aagatatact 1433461 cattgttatt ggatcagtta cagacatctc ccgtttcgaa aaaagagttc ttcatacaaa 1433521 atagcagcca aataagccgt cctcaaaggg cggtttttca tattatcaga atataacaac 1433581 tttaatgaac tgagcgtcaa tttcttaaaa tttcattgac taagcacagg cgttccgata 1433641 gcatattgta ccatataata aaaaaaggag gggcctattt gaataaagaa gcgctagtca 1433701 ataggctgaa tgcttcagcc aaaagacaaa aagctgatat cgtcattaaa aacggaaaaa 1433761 tcatggacgt atataatcaa gaatggatat atgaagatat tgcgattaca gatggagtta 1433821 ttgtaggcct cggtgagtat gaaggcgaaa atatcattga tgcagaggga caaatgattg 1433881 ttccgggttt tattgatgga catgtacata ttgagtcgtc aatggttaca ccgattgagt 1433941 tcgctaaagc agtgttgcct catggcgtga cgacggttgt tacagatccg catgagatcg 1434001 cgaatgtgtc tggtgaaaaa gggattgagt ttatgcttga acaagctcgg catacaccgc 1434061 tgaatatcca ttttatgctt ccttccagtg tgcctgccgc aagttttgag cgatcaggcg 1434121 caattctcaa agctgccgat ctcaagcctt tttatgaaga agaagaagta ttagggctgg 1434181 ctgaagttat ggattatgtg tcggttcagc aggctgaaaa agacatggtt cagaaactgc 1434241 ttgatgcccg tgtggcagga aaaaggatag acggtcattt agctggttta tcaacagacc 1434301 tcattaacat ttacagaacc gcatttgtct taaacgacca tgaagtaaca tcgaaggaag 1434361 aagcccttga tcgtatcaga aggggcatgt atgtcatgat gcgtgaagga tcagtcgcca 1434421 aaaacacgct caatgtgctg ccggcggtga atgaaaagaa cgcacgccgg ttctttttct 1434481 gtacggatga taagcatgtg gatgatttat tgtcagaggg aagtgtaaac catcaggtga 1434541 aaatggcgat tcaagccgga cttaatccgt ttttagccta tcagctagga agcctcaatg 1434601 cagccgaatg ctacggatta gatacaaagg gagcgattgc cccgggtttt gacgctgatt 1434661 tgctttttgt atctgatctg gaaaatgtca ctgtcacaat gacgatggta aaagggcaga 1434721 ctgttgctga agacagcaaa gcggtctatc aggatcatgc ttcaactgca gcaccagatc 1434781 aggcactgct tgattctgtt aagcttgctg ctcctcttaa caaacaggat tttcatatgc 1434841 caatcgattc agagcagcag atcaatgtca ttcaaatcat accaaatcag cttgaaacac 1434901 gattagtaca agttccggct cctgttgccc gcgaatttga gcctgacact gagcttgatt 1434961 tgttaaagat tgcagttgtc gagcggcata aaggattaaa agaaaccgga cttggtgttg 1435021 tgaaaggttt tggattcaag agcggagcga ttgccacaac catttcacac gactcccata 1435081 atattattgc cgtcggaacg aatgatgagg atatcgcggc ggcagttaat aagctgcagg 1435141 aaattggcgg aggattaaca attataaaaa atggggaaga gctccattca gtaccgctgc 1435201 cgattgcagg gttattatcc gaccaatctg cagagcaagt gaatcaaagc ttgctgacgc 1435261 ttcatgataa attgtcgtta atcggtttca caggcggatt taatccattt ttgacattgt 1435321 cgtttttagc gttgcctgtc attcctgata ttaaaatgac gactacggga ttattcgatg 1435381 taaaatcatt tcaacacata tcactgcaat aaaaagaggc actcccttag ggagtgcctc 1435441 tttttttaaa cctccataat gatcggcagg atcattggac ggcgctttgt tttttcgtac 1435501 aagaaaggtg caagcgtgtc tgtaatttcg tttttgattt cagaccattg agtcgttttt 1435561 cgttccatta ctttttgtaa gtgatttgaa atgagctctt gagcgtcgtt gatcaagtca 1435621 ccagattctc tcatgtacac aaatcctctg gaaatcaaat caggacccgc tgaaatcttg 1435681 aagtcgtcca tgtcaatgct gacaacaacg atgacaagtc cttcttcaga gagaattctg 1435741 cgatcacgaa gtacgatatt gccaatatca ccgataccgc ttccgtcaat gtacactgaa 1435801 ccggacggga tttttcctgc aactgaagcc tcatcgcctt taagtgctaa tacttcacca 1435861 ttatccatga taaagcagtt ttcctctggg atgccacaat ctgttgcaag tttgacatgc 1435921 atcttttgca ttctgtactc accgtgaatc ggcatgaaga atttaggctt gattaaacga 1435981 agcatcagct tctgttcttc ctgtccgccg tgaccggatg tatggatatc gttaagaggg 1436041 ccgtgaataa cctcagcacc cgcacgatac agctggttga ttgttcgact cacgctgatt 1436101 gtgttgcctg ggatagggga tgaagaaaat acgactgtat ccccaggatt gattgaaatt 1436161 tggcggtgtg tgccgtttgc aattcttgat aacgccgcca ttggttcccc ttggcttcct 1436221 gtacataaaa ttgttacttt attagcaggc atacgattga tttcgttatg ctcaataaac 1436281 gtatttttag gacagttaat ataaccgagt gtctgtccaa tttcgatagc cgattccata 1436341 ctgcgtccaa atacggcaac ttttcttcca ttttgtacag cagcttcaat tacctgctgc 1436401 aagcggtgaa tattcgacgc aaatgtggcg aagataattc ggccgtccac cttgcggaaa 1436461 atgtcatgaa tgctttctcc tacacggcgc tcagacatgg taaactccgg attttcactg 1436521 tttgtgctgt ctgaaagaag gcacaaaacg ccttctttac cgatttcggc cattttcgtt 1436581 aagtttgccg gctcgccgac tggagtaaag tcgaatttga aatccccagt atgtacgatg 1436641 tttccgggcg gcgtttttac aacaatgccg taggaatccg gaatactgtg tgttgttctg 1436701 aagaatgaca cagccgtttt gcggaacttt acaatatcat cctcgccgat aatgttcagt 1436761 ttcgtctgtc tcaataatcc atgctcttca agtttattcc gaagtaagcc gatcgcgagt 1436821 tttccgccgt atacaggaat attcacttgt ctgagcaggt atggaatacc gccgatgtgg 1436881 tcttcgtgcc cgtgggtgat aaaaagccct ttaattttat cttcgttttt gactaaatac 1436941 gtataatcag ggatgacgta gtcaattccg agcagttcgt cctcgggaaa cttgatcccc 1437001 gcatcaatca gtacaatttc atcctggaat tgcaccgcgt acgtattttt accgatttcg 1437061 cccaaacctc cgagggcgaa aacagcagtc tgatcatttt ttacaaattt cataccgctc 1437121 ataactccaa tactttaaaa ttttcgctct gttgttcata ttctaagaat gcaccatcaa 1437181 caggtgtaat aaactcaata ttaaatttct tttctttcag ctttgttctg acgtcacgct 1437241 cagatacgcc ttcaatataa agtgaatctg tcttttcccg aacaggtact tcgtcagcct 1437301 tctcttgata aaatacctta taaatcattc caaatctctc cttaaatgcc gtatgttaga 1437361 ctcgctcatt ctattatatt cgaaaacgga atataaggaa agccttgagc aaaataagga 1437421 tctctcaaaa agtgaaagat cccttgtcag gcaattgctt tcttacggag cattccgttc 1437481 cattgtcttc tgagtttctt tcttaattta cgcagcatta gccagtccct cctttaatga 1437541 aaaatttgtc ccagagttct tttatacaaa tagtatacgg agattgagga agacttttcg 1437601 tggttattaa tggaatttaa tatgattttt gaacgaaatt gtttgctgaa tgacaatctt 1437661 tttgtatgat gagggtggga attgcagacc aagacgataa aggggaagtt gcgatggatt 1437721 ctaaattaat cttttttgat attgacggca caatatatga tcatgataag aatataccgg 1437781 aaagtacgag aaaaaccgtg gcggagcttc agcgccaagg gcatcatgtg tttattgcca 1437841 gcggccggtc tccatttttg gttaagccga ttttggagga gctgggcatc cactcattta 1437901 tttcctacaa tggacagttt gttgtctttg aaaatcaagt gatttataaa aatccgctgc 1437961 ctgaaaatgc aatcaggcga ttattaaagc aggcggatga aggcaagcat cctgttgtgt 1438021 ttatggctga ggacacgatg aaagcgactg ttgcggatca cccccatgtt ctcgagggaa 1438081 tcggcagcct taaaacagat tatccagaga ccgatgacct tttttatgaa ggaaaagaaa 1438141 tttttcagct tcttttattt tgtcaggatg aagaagaaaa agcttatgcc gcttttcctg 1438201 agtttgatct agttcgctgg catgagctat cgactgatgt tctgccgcac ggaggttcga 1438261 aggcagaagg aatcaaaaaa gtgattgagc gtcttccgtt tgatatcggc gatacatatg 1438321 ctttcggcga cggattaaat gatttgcaaa tgattgaata cgttgggaca ggcgttgcta 1438381 tgggaaatgc tgttcccgaa ctgaaagaaa tcgcggactt tgtaacaaaa ccggtggacg 1438441 aggatggaat tgcatacgct gtcaaagaat tgggcctttt aaaataaaga aacggctggc 1438501 attgtgccag ccgttttctc ttttagcgct caattgcgat tgcattttca ggttctttga 1438561 aaggattttc cttatcaata tgatcataga acataacgcc gttcaaatga tcgatctcat 1438621 gctgaaacac aatagccgga aatcctttta aacgaatatc aatattttcg ccttctagtg 1438681 ttgttccttt tactctgatg cgagcatagc ggggaacata accgggaatc gcttcatcca 1438741 cagagaggca gccctcgccg cttgttaagt agcttttttc aactgaatgg ctgacgatct 1438801 taggattaaa cagagcatag ctgtataatt taccggaagc atcttccgca tgaacggcga 1438861 tcattcgttt tttgatatta atttgaggag ctgcgagtcc tacgccaggg cgcagcttgt 1438921 atttttcggc taattctgga ttttggctgt ttttaacaaa ttcgatcatg tcggccagct 1438981 gctgtttttc tgcatcagtt ggaggcagct caacaggttc ggcagtctct ctgagggctg 1439041 gatggccgtc acgtacgatg ttttccatag taatcaagaa acttcactcc taaagcttaa 1439101 tatgtaaatt atatcggatt tcttcacaaa ggtgcaacga aacgaatgac cagccgtata 1439161 tggctggtca atttcatgct gtgtggttag caacagcctc cacctaaata agcagctccg 1439221 acaatgatta acagaatgaa taaaacaacg attagcgcaa aggtgcggcc gtagccatat 1439281 ccgcagccac catatccgta accaccataa ctgcagcagc ctccgccgta accatatcca 1439341 tacatattac ataacctcct cttttaatta cgccagagcc tttataagta ggcatagcgt 1439401 ctaatataac ctatgtaaaa acaaaaaagt tgtatggtca tctgtcctga tttttcactt 1439461 ttttgattta atttcagtat tgcatttata cagcacggct attgccaaat gtccccatgg 1439521 attctatagt agaaattgtc aagattgggg gatttaacgt gaaagacgct ataaaacggc 1439581 ggcctggaat caagatcgga gctttttgtg ccatggcact gatattaaca ggatgcatgg 1439641 gacaggaccc ggttgattca cttcatcatt cattagaaaa agccgcggaa tcggaaaagc 1439701 cgtttcaaga agaacaaaac acactcaaag aattagaggc caaagaaaat cagctttacg 1439761 atagtgttat gaagctcaat atggatgatt ataaaaaaat tgttgcttta tctaataagg 1439821 cgcttgaaaa tgtcagcaag cgcgaagaac acctaaagct tgaaaatgac agcatgaaaa 1439881 aatcggaaac agaatttgag gaagcaaaaa cgtcagcgga acatattaag gaaaaagaca 1439941 taaaagaaaa ggccgatgcc gcagcaaacc atatggagaa aagatataca tcatatggca 1440001 ctatgtataa agagtataaa aaagcgcttg agcttaataa aaaactgtat atgcagctga 1440061 aagacaaaga tttgacaaga gatgatctgg atcagcagat cgataaagtc aatgcttctt 1440121 atgaaaagat ccttaaatat agcggagaat ttaatgaaca aaccgaaaaa tataataaag 1440181 cccgggaaga tttatatgat gctgcaggct atcgtgtgaa aaagagctga ctcgatcagc 1440241 tctttttttg aatgaaatgc gattcggatt tcgttcaaaa ttttcatttc tattgtagta 1440301 cagcatagta aggtatacta gtacagtttt gggtgcggtt ggcatctgtt tttttgatga 1440361 aaatgtaaag cgaatacatt tattgaaaat cagcgatgaa aacgattgac ggttcttctt 1440421 tatttggtgt aaactaatcc atgttaagcg gtgttgtatt agttttttac aacttcgaaa 1440481 taatacagtt caaagcagag tgtaactatc ctacataaaa ggttttggca aactggggat 1440541 cggctaaaat ataatacgac ttactgctga tactttaggg taccctaagt ttgtatgtat 1440601 aaaaggaatg cacgtctaat gactgtttaa aagaaaggaa gaggtgactt agtatggctg 1440661 caaaaacgaa aaaagctatc gttgacagta agaagcaatt tgatgccatt aaaaagcagt 1440721 tcgaaacgtt ccaaatttta aatgaaaagg gagaagtcgt gaatgaagcg gcgatgcctg 1440781 atttaactga tgatcaatta aaagagctaa tgcgccgcat ggtatttacg cgtgtgcttg 1440841 accaacgctc tatctcatta aaccgtcaag gacgtctcgg attttacgct cctactgcgg 1440901 gtcaagaagc ttctcagatt gcaacgcatt tcgcgcttga aaaagaagac tttgttcttc 1440961 ctggataccg tgatgtgcct cagttaattt ggcacggcct tccattatat caagcgtttc 1441021 ttttctctcg cggacatttc agaggaaacc aaatgcctga tgatgtgaat gccctttctc 1441081 cacaaatcat tatcggtgct caatacattc aaactgccgg tgttgcgcta ggtcttaaaa 1441141 aacgcggtaa gaaagctgtc gcaatcactt acactggtga cggcggagct tctcaagggg 1441201 acttctacga aggaattaac tttgccggag cttataaagc acctgcaatc ttcgtggtgc 1441261 aaaacaaccg ttacgcgatt tcaactcctg ttgaaaaaca atctgcagct gaaacaattg 1441321 cacaaaaagc tgtagctgcc ggtattgtcg gcgtacaagt agacggaatg gatccgcttg 1441381 ctgtatacgc agcaactgct gaagcacgcg agcgcgcaat caacggcgaa ggtccaacac 1441441 taattgaaac acttacattc cgttatggcc cgcacacaat ggctggtgac gatcctacta 1441501 aatatcgtac aaaagaaatc gaaaatgagt gggaacaaaa agatccgctt gtacgtttcc 1441561 gtgcgttcct tgaaaacaaa ggcttatggt ctgaagaaga agaagcaaaa gtgattgagg 1441621 atgcgaaaga agaaattaag caagcgatca aaaaagctga tgctgaaccg aagcaaaaag 1441681 taactgattt aatgaaaatc atgtacgaaa aaatgcctca caaccttgag gagcaatttg 1441741 aaatttatac acagaaggag tcgaagtaag ccatggcgca aatgacaatg attcaagcaa 1441801 tcacggatgc gttacgcaca gaactgaaaa atgacgaaaa tgtcttagtt ttcggagaag 1441861 acgttggtgt aaacggcggc gtattccgtg cgacagaagg attgcaaaaa gaattcggtg 1441921 aagaccgtgt gtttgacacg ccacttgctg aatctggtat cggcggtctt gcccttggtt 1441981 taggcttaaa cggcttccgt ccggtaatgg aaatccaatt cttcggattt gtttatgaag 1442041 taatggattc agtttctggc caaatggctc gtatgcgcta ccgttctggc ggacgctgga 1442101 cttcacctgt aacaattcgt tctccattcg gcggcggtgt tcatactcct gaacttcacg 1442161 ctgacagctt ggaaggtctt gttgcacaac agcctggtat caaagttgtt attccatcaa 1442221 ctccttacga tgccaaagga cttttaattt ctgcgatcag agacaatgat cctgttgtct 1442281 tcttagagca tatgaagctt taccgttctt tccgtcagga agttcctgaa gaagaataca 1442341 caattgagct tggaaaagct gacgtgaaac gtgaaggtac tgatctttca atcatcactt 1442401 acggcgcaat ggttcatgaa tcattaaaag ctgctgatga gcttgaaaaa gacggcattt 1442461 ctgctgaagt tgtcgacctt cgtacagtaa gcccacttga tatcgataca attatcgcct 1442521 ctgtagaaaa aacaggacgc gcgattgtcg ttcaagaggc acaaaaacaa gccggtattg 1442581 ctgcaaacgt agtagcagaa attaatgacc gtgcgatcct gagcttggaa gcacctgtac 1442641 ttcgcgttgc agcgccagat acagtatttc ctttctctca agcggagagc gtatggcttc 1442701 caaaccataa agacgttctt gaaacagcaa gaaaagtgct tgaattttaa tcaaactgca 1442761 taatcgagag ggaagatgaa cgttttccct ctattatata tctgttttca atgcttacga 1442821 tgtaaacttt aaaattgctt aatcaaacta ggaggtcgag aactgtggca tttgaattta 1442881 aacttccaga tatcggggaa ggtatccacg aaggcgaaat cgtaaaatgg tttgtcaagc 1442941 ctaacgacga ggtagacgaa gatgatgtac tggctgaagt ccaaaatgat aaagcagtag 1443001 tagaaattcc ttcacctgtt aaaggaaaag tattagaatt aaaagttgaa gagggaacgg 1443061 ttgcaactgt tggacaaacg attattacgt ttgatgcacc tggttacgaa gatcttcaat 1443121 ttaaaggcag cgacgagtct gacgatgcga aaactgaagc acaagttcag tcaactgcag 1443181 aagctggaca agacgttgcg aaagaagagc aagctcaaga gcctgcaaaa gctactggcg 1443241 caggacagca ggatcaagct gaagttgacc cgaacaaacg cgtgatcgct atgccttccg 1443301 tacgtaaata tgcacgtgaa aaaggtgtag acatccgtaa ggttactggt tcaggcaaca 1443361 acggacgtgt tgtaaaagaa gatatcgaca gctttgtaaa cggaggagcg caagaagctg 1443421 caccgcaaga aacagctgca ccacaagaaa cagctgctaa accggctgct gcaccagctc 1443481 cagagggcga attcccagaa acacgcgaaa aaatgagcgg tatccgtaaa gcaattgcaa 1443541 aagcgatggt taactctaaa cacactgctc ctcacgtaac gttaatggac gaagtggacg 1443601 taacaaacct tgttgcacat cgtaaacagt tcaaacaggt tgctgctgat caaggaatca 1443661 agctgactta cttgccttac gttgtaaaag ctcttacatc tgcactgaaa aaattccctg 1443721 ttttaaacac gtcaattgac gataaaacag atgaagtcat ccaaaaacat tacttcaaca 1443781 tcggtatcgc tgctgacact gaaaaaggct tgcttgtacc ggttgtgaaa aatgcagatc 1443841 gtaaatctgt ctttgaaatt tctgatgaaa tcaatggcct tgcaacaaaa gctcgtgaag 1443901 gcaagcttgc tccagctgaa atgaaaggcg catcttgcac aattacaaac atcggttctg 1443961 ccggcggaca atggttcact ccggttatca accatccaga agttgcgatt cttggtatcg 1444021 gacgcattgc agaaaaagcg attgttcgtg atggcgaaat cgtagcagct ccagtcttag 1444081 ctctttctct cagcttcgac caccgtatga tcgacggagc aactgcgcaa aatgcattaa 1444141 atcacatcaa gcgtttactg aacgatccac aattaatttt aatggaggcg taatgttatg 1444201 gtagtaggag atttccctat tgaaacagat actcttgtaa ttggtgcggg acctggcggc 1444261 tatgtagctg ccatccgcgc tgcacagctt ggacaaaaag taacagtcgt tgaaaaagca 1444321 actcttggag gcgtttgtct gaacgttgga tgtatccctt caaaagcgct gatcaatgca 1444381 ggtcaccgtt atgagaatgc aaaacattct gatgacatgg gaatcactgc tgagaatgta 1444441 acagttgatt tcacaaaagt tcaagaatgg aaagcttctg ttgtcaacaa gcttactggc 1444501 ggtgtagcag gtcttcttaa aggcaacaaa gtagatgttg taaaaggtga agcttacttt 1444561 gtagacagca attcagttcg tgttatggat gagaactctg ctcaaacata cacgtttaaa 1444621 aacgcaatca ttgctactgg ttctcgtcct atcgaattgc caaacttcaa atatagtgag 1444681 cgtgtcctga attcaactgg cgctttggct cttaaagaaa ttcctaaaaa gctcgttgtt 1444741 atcggcggcg gatacatcgg aactgaactt ggaactgcgt atgctaactt cggtactgaa 1444801 cttgttattc ttgaaggcgg agatgaaatt cttcctggct tcgaaaaaca aatgagttct 1444861 ctcgttacac gcagactgaa gaaaaaaggc aacgttgaaa tccatacaaa cgcgatggct 1444921 aaaggcgttg aagaaagacc agacggcgta acagttactt tcgaagtaaa aggcgaagaa 1444981 aaaactgttg atgctgatta cgtattgatt acagtaggac gccgtccaaa cactgatgag 1445041 cttggtcttg agcaagtcgg tatcgaaatg acggaccgcg gtatcgtgaa aactgacaaa 1445101 cagtgccgca caaacgtacc taacatttat gcaatcggtg atatcatcga aggaccgccg 1445161 cttgctcata aagcatctta cgaaggtaaa atcgctgcag aagctatcgc tggagagcct 1445221 gcagaaatcg attaccttgg tattcctgcg gttgttttct ctgagcctga acttgcatca 1445281 gttggttaca ctgaagcaca ggcgaaagaa gaaggtcttg acattgttgc tgctaaattc 1445341 ccatttgcag caaacggccg cgcgctttct cttaacgaaa cagacggctt catgaagctg 1445401 atcactcgta aagaggacgg tcttgtgatc ggtgcgcaaa tcgccggagc aagtgcttct 1445461 gatatgattt ctgaattaag cttagcgatt gaaggcggca tgactgctga agatatcgca 1445521 atgacaattc acgctcaccc aacattgggc gaaatcacaa tggaagctgc tgaagtggca 1445581 atcggaagtc cgattcacat cgtaaaataa ttttcatatc aaaaacagcc ccgctttgag 1445641 cgagggctgt ttttttattt tgacagcaca tgctgtaatg gtttaatgat gtcttctttc 1445701 tttttcacac atccctcgat tttcaccacg acatggcgct gatcaacaac cataagggta 1445761 gggacagttt caatctcatc ttcccagcct tcttttttat catagacctt cattttatct 1445821 atttgctcgg gataatcttt ttctaaatca agcagtgcat cgtaataagg cgcttcctgg 1445881 tctatttggt tctcatcaga aaaaaacagg atttgtgtat gatgaatgtt gtcaatccgg 1445941 ctttttttca tcggattgat ggtggaaagc gtacagcccg ataaagcaaa tactattatc 1446001 agcatgggga ataccgcgcg atatcgcatc tatcttctcc tctgtataaa cagtagttaa 1446061 ctagctttag tttatcacga gagacggctt aatctgcttc ttgttaccta attgttatat 1446121 aattgaaacc gtttttaaag tgagattaca tattatatca atcgtttaaa atagcaacct 1446181 ggggtatatt gaattttttg ctgcattctt ggatgaaagt tcaagaaaac gtgcaattac 1446241 attatgtgct gtggcatata tatcgagtaa agcttctgta tgaagaagat attgtatgat 1446301 ggaaaatgga aaaacaaggt gaatatgatg atatgaaata aaatgtgtta tacagtttgt 1446361 tgttgacatt ttaaatgtga catattaata taataacaac aaaagaaatt aagcgttttc 1446421 aaatttcaaa gaaatgggga ataagagatg ggtacgattg tttgccaaga ttgcaacgaa 1446481 gccattcatt actttgaaga tgagaaagtg acaacattat atggaacttg ctgcggacaa 1446541 tgtcaatgtc ctgttgatga agagtaaaaa aaagcatgcg gcttaaagcc gcatgctttt 1446601 tattttttat tgaattgctt tttgttcttt gatgacccgg atcatatgta aagtcgagtc 1446661 ctcaggtcct tgaacaggga ggcctgcgtc aaggttttta aaaatgtagc tgatgttttc 1446721 ttctgtaata atttctcctg ggatgaagat tggaatacca ggcggatata ccatgacaaa 1446781 ttcagcaata atccgtccgg atgcttcttt taatgggatg acttccgtat ttgcatagaa 1446841 agcatcacgc ggagtcattg ccaataaagg tatttctgga agcagaacct cagtttgctg 1446901 atgtgttaca tcttgttctg acatttgctg tgcgatctca gttaaagcct ctacaagccg 1446961 gtctgcatca ttttggctgt caccaggagt gaaaatacac aaaatattgt acagatcaga 1447021 aagctccacc tcaatattaa aggattcacg aagccatttt tccacgtcat gtcctgtcag 1447081 gccaagactt ttcacagaga taatcaattt tgtcggatca tagctgtaag ctgctttcga 1447141 cccaagaatc tcagaaccga cacaataaat gccttcaatc tgattgaggc gatctctcgt 1447201 ctgattggca agcttgagtg tttcctcagc aagctggcgg ccttctgttg caaggcgttt 1447261 tctggcaaca tccaaagaag cgagaagcaa gtaagaagtt gacgtagttg tcagcatgct 1447321 caggatggat tgcactctgt ctttagatac aaggccttct ctcatgttta aaatagagct 1447381 ttgtgtcagt gatccgccca gcttgtgtac acttgtcgct gctatgtccg ctcctgcctg 1447441 catagccgat agcggcaatt cgtcgtgaaa atgaatgtga acgccgtgtg cttcatccac 1447501 aagcactggc acatcaaacg aatgagcgag ttctacgatg ctttttaagt cggctgcaac 1447561 accgaaatat gtcgggttga tgacgagaag cccttttgca tccggatgct cggtaagcgc 1447621 ccgtttagca gattcaagtg taattccgtg ggagatgccc aattcattgt caatttcagg 1447681 atgaataaaa attggaaccg ctccggaaaa tacaatagct gtcataattg atttatgaac 1447741 atttcttgga ataataattt tatcaccagg tccgcaaaca gccattacca ttgtcataat 1447801 ggcgccgctt gttccttgaa cagaaaaaaa tgtatgatcc gctccaaatg cttcagcagc 1447861 cagatcttgt gcttgtttaa taatgccttt tggcgcgtgc agatcgtcta atggttcaat 1447921 attaatcaaa tctatgctta acgcgttttc accgataaat tgtctgaatt ctgggtccat 1447981 tcctgcccct tttttatggc cgggaatgtg gaattgaaca ggctgtctgc ttgcatgctt 1448041 tttcagtcct gtgtataagg gtgtttcatg ttgcgacaat tgttttccca cctttgtaat 1448101 catacctatg cataatagtg tgtattaaaa tcagtttctc aaccgttttt tagacgtaaa 1448161 acaaatgaat tatattatga acttgaaaga atgtaaagaa caatttatga tcaaatgaag 1448221 atgctttctc ttaagggaag taaatctaca aggagtgaag aaaatggagt atcaatatcc 1448281 gatgaatgaa gattggacaa ccgaagaagc agtggatgtg attgcatttt tccagcaggt 1448341 tgagcttgca tatgaaaaag gggcggatcg tgaagaactg cttaaagctt accgccgttt 1448401 caaggaaatt gtaccgggga aggccgaaga aaaaaagcta tgcggcgagt ttgaggaaca 1448461 aagtacatat tctccttatc gcacggtcaa acaggcgaga gaatctgatc acgcgaagat 1448521 taagatgtaa gaaaaagagc cgggggatat cccggctctt ttttatgctt gtgttacttt 1448581 ttgggtgaga cggtacagaa aagcaagctg tttaaaggca tcgtcgatac gctgaaggaa 1448641 ttcctggtta ttcatattca gcacttcttc tttttggagc tggatgccgc ataacagctc 1448701 ggctttcttt acagtctgca aacgctcaaa cagtgtcttc agctgttcct tgtccatttc 1448761 agactgttta tgtactcccg gttttgtgtg atctgcagac caaacgaagc tgtcagggat 1448821 atttttcgta atggtttctt ggttcacttc aagcaatttg ccgtattctt ctttgatagg 1448881 ggattcataa ataatcgcga accatacaaa gacgtggctt tcccataaac caatttggaa 1448941 atgcggcagt tttttatagc ctcttttgct gtttgcgaac gccacccagc tgtcagccgg 1449001 gggattgacg gatcttcttg cgtgctttgc cacatgcgga aacatttcat ctccggttaa 1449061 agctgataaa gttggggcaa aatgttcgcc tagagctgta agcttcggac ggaccgtctc 1449121 ttttaatact tccatgcgcg cgtctaagcc ttctattgta aatgtgttaa agtcttcttc 1449181 agtgaaacgc atttgtgtca tgattttcct ccttcatgct aagtatacat attttatcac 1449241 agttcatacg agcttcaaaa agattgagcg cgtttgaagt aaggagaaat gtggtaataa 1449301 acgagtaggt aaacacacaa ttttcagaat catgttgcgc gtaaatagaa caatcatacg 1449361 atataagaag taatcattgt tgaatggcaa aatgggatgc ttttttacaa acaaatgatc 1449421 tctggaaggg gcgaaagaca atgaggcaag ttgtaaaaga gggatttaag gaagagaaaa 1449481 acaatcgtgt tgctgtctgg agactagagg ttgattatga attggcaacc ctatatgaag 1449541 caatgcagaa agaaaatgaa gagcagattg aacaaagcaa aaacaaactt gagcgactta 1449601 gaaaagaatg gattcgtctt aacgggtaaa aaagcgatag tgaaaacgaa ccgcatgaat 1449661 ggttcgtttt tacgtgagaa gggatatttt tcattttcct tgctttttca ttgccgttat 1449721 cagtatccta taaaataaaa ggtctacata gaagagaggt acgaacgaat gacaaattgg 1449781 acggaaatcg atgagattgc aaagaaatgg ataagagaag caggcgcgag aattacacaa 1449841 tccatgcatg aaagcctgac aattgaaacg aaatcaaatc cgaatgattt agtcaccaat 1449901 attgacaaag aaaccgaaaa gtttttcatt gatcgaattc aagaaacatt tccgggacat 1449961 cggatactcg gtgaagaggg gcaaggagac aaaatccact cacttgaggg agtcgtatgg 1450021 attattgatc cgattgatgg gacgatgaat tttgtgcacc agcaaagaaa ttttgcgatt 1450081 tccattggga tttttgaaaa cggtgaaggt aaaatcggtt taatttatga tgtggtgcac 1450141 gatgagttgt atcacgcatt tagcggcaga ggagcttata tgaatgaaac gaagctggct 1450201 ccattaaaag aaaccgtcat tgaagaagcg attcttgcca ttaatgcaac atgggtaacg 1450261 gaaaacagaa gaattgatca aagtgtgtta gcgccacttg tgaaaagagt cagaggcaca 1450321 cgctcctacg gttctgccgc tttagagctg gcaaatgtcg cggcaggaag aatagatgct 1450381 tacatcacga tgcggcttgc gccatgggac tacgcagccg gctgtgtgct gttaaatgaa 1450441 gtaggaggca cctatacgac cattgaagga gagccgttta cctttttaga aaaccacagt 1450501 gtgctagccg gaaacccatc tatacataaa acgatatttg aagagtatct tcatgctcgg 1450561 aagtaggcca tttgagcagg atgatctcag cttgttagaa aagctcgcgg aggctcatcc 1450621 tgtatggaaa gaggaggagt ttggagataa agatgcagaa gactatatca tttcctactc 1450681 catgtacaac ggttcatggc ttgtatggga aaaagacggt atgcctgttg ccgtcagcta 1450741 ccatctcgag tggtctcctt caaacggtaa gccgtggctc ggaacggtcc tgattgaccc 1450801 ggctgaagaa aaaaagggac atgcgaagat gatcattgaa cagatcagca aattgcttag 1450861 agcgaaacat aaagcgatgt ttgcgggagt tcccattgag cgcagggaat ggatactgtt 1450921 tttaagccaa tgcggctttg aacagctgaa aacggaaaaa gatgagaaag gcaaatcatt 1450981 tatgatcttg gtgaagcctt tagcagaagc tgccgtatga taatggcagc ttatttgctg 1451041 catgcgggtt caataaaaag cctctcaaac attgagaggc ttctgatgat ttgaaaatta 1451101 tttttttacc gcatgaatat aatgaatcgt ttcaaacgct gacaaattgt cttttcgatt 1451161 actaaagaaa aggtcattga tgtcgtctgg tgatagatgt tcatagatca gtaaaccaga 1451221 tgactctaac agatgttcaa tctcttgata agtgaaacat gatttcatcg gttccccgct 1451281 tgcggcagcc atcttcacca tatgttcaac tcgattcgac gtcccttttg ctgtaaaaag 1451341 tgtttcgtcc gcataatcaa aaacaataga gcttccaggc gggacatgag aaaataaatt 1451401 gctgatcaag cttgcatttt cttcccgtgt tacataataa gacactccga gaaggctgaa 1451461 gaatgttttt gtgtttttaa atccttcatc taagagagga tcatacgaaa acgttttggt 1451521 gaaatccata ggaacaaaat gaagatgacc cggaattgtc agatttgcat ccttcagctt 1451581 attttttttc aattgctgtg tggccggatg atcaacctcg aaaacctgta agctgttttc 1451641 taattctgga tgccgaaagc agaaagtatc cagtcccgct ccaagaatga catactgttt 1451701 tgcccccagg attaattcgt tgtgcaagac tttttcacaa taagaagcac gtgctagggg 1451761 cgttggagac agctggattt gtgcaaccca ttttaatatt ttttcaggat cattttgaag 1451821 acgttcggcg atctctttgt tgaaaaacga tatttcttga atcatatttt tactgatgtc 1451881 gataaactct ttttcgttaa tgagatcttt tgcgataaaa tcatcaaaaa taagaggtgt 1451941 gtcatatcgg ctgtgatatg cacgggcaaa agctgaaatt agagacgtta agctggactc 1452001 atttttcctc atgaaatgat cctccacaaa aaataagatt cccctggcca ggagaatctt 1452061 attatacata caaatatatt aatagtaaat tttagcataa ataaattttt ttgtcaatgt 1452121 ttttgctctt aactggacgc gcgatccttc acatagccac gtgacctgta gcagaattcg 1452181 tctatcaatt atgtggactg aatcattagc ttttataaaa tgcgcacttg cggctgcatc 1452241 cctctttatg caaatcagga gcggttttct gtctcatggc agcatctttt cgtcgtttca 1452301 gctgagagag aaatcaagat atgtaacaat aaaagcctga gggatctcag gcttttccta 1452361 atattacaat ccaacagcat tccaggctgc ttcaacttta gcggcatcag ttgagccgta 1452421 gaggtcacgg gcagactgaa tgagagctgc cttggcatct ttgaacgtgg aagaaggcgt 1452481 gaggtacgtt gttaacgcac ggtaatagat ttgctgtgat ttagatacac caagttttgt 1452541 gatggtgttg taagcggctt tgtttggaat tccgctgttt gtgtgtacac cgccataatc 1452601 gccttcatct gtgtttggaa ggtttcggta attggcgtaa ttgtcaggct ggttgtattt 1452661 tgtagggttg gacaggctgc gaagagcagg ctggctgacc gtaatgtctt caccgatgtc 1452721 ccagtcttct gtatcgttaa aatacccgaa tacgtcagag aaagactcgt ttaatgcacc 1452781 tggctgattt tcataaatca agttggctgt ttcttgggtg acgccatgtg tcatttcatg 1452841 cgctgtcaca tctaatgagc cggaaagcgg agagaagaat gaaccgtcgc catcaccgta 1452901 aatcatctgg tctcctgtcc atgcagcgtt attgtattga gtgccgtagt gaacggaaga 1452961 aacgatttta ctgcctttgt tatcatagct gtttcgttta aagtttgaat aaaaataatc 1453021 gtacacttta ccgaggttat agtgtgcgtc aacggctgcc cgctgtgatg aagatgtaaa 1453081 tgttttcgtt gtgcttgaga caagcgtgcc cggaaggcgg ctttgtctgt tttgcaaatc 1453141 atatgtgatg atttgggtgc ctgttggttt tgaaagatct cttagaacat attttccgcc 1453201 ttcataagag atgttcaaag gaacagttgc gccctttagc gttgttccgc ttccagtggc 1453261 ggcggcatgt tctactttat tttgctgttt taaaatgctg cctgtttcgg cgtcaactaa 1453321 gacttcccag tttgcaggtt caggctcgac atagcgaatc gtcacgtcgt aagcaagacg 1453381 atagctgccg tcttttgttt ctatcgcttt taattcggct ttattgctgt ttttggccgc 1453441 tccgttagaa acagcgtctg gtgatttgcc gatagctttg aaagcgagtg ccagcgcttt 1453501 ttcagaagag actttttggc tgttatctgt ttttgcagca gattgattgt gtaattcacc 1453561 attgaccgca tagacattat cggatttatc gacgtgaacg atcacttgcg aatctttaat 1453621 tggcactccg ttaacgacag gcgcatatcg aaagtgcttg tatccaaggg catcagtcgt 1453681 gctttcaaca agcttcagcc ttttggaagg gtcaccttta aaaatgttgc tgttcttttt 1453741 caaaaactgc ttgacagcct tgtcatttgg tgcagagagt tctgattgcg caatcgcgtt 1453801 tttggagagg aaatttgttt gattctcttt aagctgatga ccttcagcag cctgaacacc 1453861 tggcaggctg attgataaac tcataaacga agcagcgaca gcaacagaca atttcttacc 1453921 taaacccaca ataaatcccc ctttttgaaa atactgaaaa ctttatattg ttatattaaa 1453981 ctagcattct ggaatactca acaaaaacta acataactag acaaaattga tagtattgtc 1454041 ctgtgtttgt ttttgttgaa taatatcaag atgagtcaag tgtcatgtgg tggttcattc 1454101 aagagttatg ttttttacat atcaagggga agatgagata tttttgtttc atcttgaaac 1454161 tttttgaaaa gtccgctgtc taaccgaatg aggccttaat aagaagtaaa ggattgttgt 1454221 tcgtgttgga gttattcagt cattatgtat tgcatttcga acgttatttt atattaagca 1454281 gacaaagcac cctgctgatt caatggtcaa ttgttgttct ggcgggctta tatcttttgg 1454341 tgcatcatcc caaaataaac cggcagcgca caatgttctt ggcgggtgtt atattgcgga 1454401 ttgtgctgct ggcgggagtg tctgttgaac ttattcacca ggtgcaatca acaaacttca 1454461 ccagcgctta cttaagagag gacggaaaag aactgctgcc gctgctgcat tttttgttat 1454521 acggatatgt gctgctgacg gcttttcact atatgctgat gccgcgtgat catggcggaa 1454581 agggtaagtt ttatacgttc gaccttgctg ttgtcagttt gccgatcgta caaatgattt 1454641 ttagtttctt ttcgtattgg aaggaatacc cggatgggat ggagccgatt gcattcgtgt 1454701 ttctgttttt catcatcact cttcccattg cgttgaatgt agtgtttttc aagctgtatt 1454761 ggagaacgga taagatctta ctaggcttat tttatacgct gattatcgga ctgcttgtct 1454821 tgctgcttgc gccatatccc aatcaaatct caaaagatta tggtgcagta atgccatata 1454881 cgatttattt ggcaatggcg ggatttttga tgagctatca tctgttccaa aagtcaggaa 1454941 aggtttatgt gcgtgtgaat aagtgggtga cgatggctgt catggtgttt tttgtcctgc 1455001 tgttaaatcc gatatataac ataggaacgg ctgctttcgc tgtatcaaag ccagcaaatg 1455061 tccatgattc attcaatttt gtcggggagc acatttcatc agaaaaagcg gaacagatac 1455121 taaagtcatt ttttcctacg gatgaaacac tttatttgca cgatacaaac atggatgtgc 1455181 attatttcta ctcatttgaa agcaaaggtt acaaagctga ggtagatgaa gtatcgcagc 1455241 taattcgtaa ttatgaatac ttacaaaaag cacatgggaa aaagctaacg aatcaggagt 1455301 acaagcgaaa gtccatcgct ttccttgagc gacacggacg tgtgttacat aaggatcata 1455361 tcgaaacaaa ggtatctcaa gaagacggcc agacagtcgt acgtatttac ctgaaaaatc 1455421 aacttcataa aaaagatcat gctgatgatg gcgcggtatt ttattgggaa aaggaaacct 1455481 taatggggtt tagtgaagat ccttcgattt atcagcttga ctctcttctg catgttcata 1455541 taacggaaca agacattcac gacaaagtgg aacaaatgtt tacagcgctg aacatatcaa 1455601 aacagcctta tcagatcact gatattgaaa gcgacagcct gcttggaagc atggtgagag 1455661 ttgaaacaaa agttggaatt gttttggaat ttgagggcga atcaggttgt ttacatagtc 1455721 tttcgcttcc gatgaaaaag aatatctcaa tggctaacag ccggctgcag catcagatat 1455781 tatcgatctt cgatgctcgt ggatcagaaa agaagaaaaa aagcagtcag ggtgacatgg 1455841 tgatgtatac tgattcttct aaaacatatg agtttgttga agctcaaggt cagctaaacg 1455901 tttatgtata cagcgataca cctgatcagt cattccccta tacgtatcgt aatggaacat 1455961 tggcttacga aaaagtagct tctctatatc aggatgtcat ttacaaaaag cgtatgcgtc 1456021 cgattatcgt tcaaagaggg gatgaacggc attatgcatg gctgatcatt attcagccgt 1456081 ttggttcaaa tcgccatgat gcctatgtag tggatggaga aacacaagag gtgaaaagtc 1456141 tttatgaatc ataaagaaaa agagtctgtt tttgtagact tatacgacct gtataaagaa 1456201 ggagagctag aggatgaatc aatggaatgg atgaaacagc atgaatccct atttcaaaag 1456261 aatgcggaag acttaaagag taaaacttgt ttaaagagaa gtcccggtgc tgaagaagaa 1456321 agccaaatca gatatatgaa agtatacctg tcttccatgt atatctgttt cattttattg 1456381 gccatttgga tgacggtgtg gttttatttt taatgaagca tagggattcc attgaggact 1456441 tgtatcggca gtattatcaa gaaattttaa attatttatt cagaaggact catcatcttg 1456501 aaacagccaa ggacttagcg caggacacgt ttgtaaaagc tcttaacggt ctggcttcgt 1456561 ttagggggca ttcttccatc agaacatggc tctacaccat tgcgcatcat acctttatca 1456621 attggtaccg aagggatgtc aaataccaat ttactgaaat cagcaaaaat gaagggttaa 1456681 cgcaaacaac ttatgaccag cctgaacagt atctgtcacg gacggtgaaa agcgaaacac 1456741 tgcggcagga gctcctgaag ttaaaagatc agcatcaatc cgttttgatt ttaagagaat 1456801 tccaagagct ttcttatgaa gaaatcgctg agatattagg atggagtctt tctaaggtga 1456861 ataccacatt gcaccgggct agattagagc taaagaaaaa catgacgaaa agtagagagg 1456921 aggagcggat atgacctgct ttctagtaag agacctgctt cctctgtatc ttgaaggtga 1456981 ttgtaaaaga gaaacggaac acgttataga agagcattta aaaatgtgca gcagctgcag 1457041 agacatgtat gacacgatgg ctgagccatt tgaattggaa agcgaacagg ccgttgagga 1457101 ggcttatctg ccggaagaag aactgcgttt taaacagagg tactatggat tactgatcat 1457161 gaaagctgcc tgctggtttg gagcggcggt tgccatgatg ctgatcatca aactgctgat 1457221 ataaaaaaag cgcttgtccg attccggcaa gcgctttttt acattaagcc tggggatgaa 1457281 tcatatcgta aatagcggca agctgttctt gtgacagggc actgaagagt ttttcataaa 1457341 cgtcagcttg cagtggcgtt gcacctgctt gtagcgctgc gtctttatca tagctgtaca 1457401 catcatcttg tagcacaatg gctgcttgaa gaatgtgaat cttgagagaa acagcggaga 1457461 aaaattgttc aagtgcaagt gcttcttttt ctgtgaagcc aagttcaact gctttttctg 1457521 tatcaaattt gtaatttcca tcctcgagat acacacattg tgaaacaatg ctgaaaaatt 1457581 ctgatgtcga ttcccagagt gtagcaatta cctgagcctc ttcttttgtc attcctaact 1457641 cgacagcttt ttcgctgtca aaataatata caccgtcttg ttcgtatata cattgattta 1457701 atatatcaat gaatgtattg agatcttcgt tagtgctcgc ctgatgctgg agttgaacag 1457761 cagtgttatc aaccggtgtt tttgcgctgg ctgcatcagg accgaacgtt aatagagcag 1457821 ctgaggtcat tgcggcagtc gttaacatag ctttttttac aaatgttttc ttcatgtttc 1457881 ttctctccct tttatgaatt gtgctacaaa ttccattata gggagtagtt tccggtggag 1457941 gaataggcgc tatggtattt tatgtgtatc gttgccgaac tactttttga aggctgcacg 1458001 tgtgatcgtt agaacgattg tctatgtatg aaggctgttt tgcatcttcc tgactaagaa 1458061 acaggggaga taaggcttaa agaaatgaaa aacaccgctt tctttgcggt gttttttgat 1458121 tacaatgtcg ccggcggggc aatgctttta atcaagcaag ccttgttcgc gcattttctt 1458181 ttttaatgta aatccgccgc ccatgacagc gcaaacaagt acaatgctgg cgataatgcc 1458241 tgcagggctt ttttcagcga taaagacgcc gatcagcata atgctgaaaa ccgctgcaaa 1458301 tgcaaataat agtaaaagcc aattcatttt tttcataaat tccatcccct tttacgtctt 1458361 atattaagtt tacagaaaaa cgtgacgctt ttaaagagga tgtgtgatat aatatgaaag 1458421 ttatctaatt tttttaggag atgaaaaagt gaaacttcga aatgatcttc gcaacatcgc 1458481 gattattgcc cacgttgacc atgggaaaac gactctagtc gatcagcttt tacatcaggc 1458541 tggtacgttc cgtgccaacg aacaggttgc tgaacgcgca atggactcta atgatcttga 1458601 acgcgaacgc ggcattacaa tattggcgaa aaatactgcg attaactata aagatacacg 1458661 tatcaatatt ttggacaccc ctggacatgc agactttggg ggagaagtag aacggattat 1458721 gaaaatggtt gacggcgtag tgcttgtcgt tgacgcatat gaaggctgta tgcctcaaac 1458781 tcgttttgtt ctgaaaaaag ctcttgagca aaacctgaac cctgttgttg ttgtaaacaa 1458841 aattgaccgt gactttgctc gtccagagga agttatcgat gaagttctgg atctgttcat 1458901 tgagcttgat gccaatgaag agcagctcga gttcccagtg gtatatgctt ccgcgattaa 1458961 tggaacagcg agtcttgatc cgaaacaaca ggatgaaaac atggaagctt tatatgaaac 1459021 cattattaag catgttccgg cacctgttga taatgcagag gagccgcttc aattccaagt 1459081 tgcccttctt gactacaacg actatgtagg ccgtatcgga atcggacgcg tattccgcgg 1459141 cacaatgaaa gtcggacagc aggtttctct tatgaagctt gacggaacgg caaagtcatt 1459201 ccgtgttaca aagatttttg gtttccaagg cttaaagcgt gtggaaattg aagaagcaaa 1459261 agcgggagac ctcgttgcgg tttccgggat ggaagatatc aacgttggtg aaacggtatg 1459321 tcctgtagac catcaagatc cgcttccggt ccttcgcatt gatgagccga cacttcaaat 1459381 gacatttgtc gtgaataaca gtccgtttgc aggccgtgaa ggcaaatatg taacggcccg 1459441 caaaatcgaa gagcgtcttc aatcacagct tcagacggat gtgagcttgc gtgttgagcc 1459501 aacagcttct cctgatgctt gggttgtttc aggacgcggt gagctgcact tgtcaatttt 1459561 aattgaaaat atgcgtcgtg agggctatga gcttcaagtg tcaaaacctg aagttattat 1459621 caaagaaatc gacggcgtac gctgtgagcc tgttgaacgt gtgcaaattg atgttcctga 1459681 agagcatact ggctctgtaa tggaatcaat gggtgcccgc aaaggcgaaa tggttgatat 1459741 gatcaacaac ggaaacggcc aagtccgtct catctttaca gttccttccc gcggattgat 1459801 cggttactct acagaattcc tatcattaac acgcggattc ggtattttga accatacgtt 1459861 tgacagctac cagccgatgc aggcaggcca agtcggcgga cgccgtcaag gtgtacttgt 1459921 gtcaatggaa aacggaaaag caacatcata cggtattcaa ggaattgaag accgcggtgt 1459981 catcttcgtt gagccgggta ctgaagtata cgaaggaatg atcgttggag agcataaccg 1460041 tgacaacgac cttgttgtta acgtcagcaa aatgaaacag caaacaaacg tccgttctgc 1460101 gacaaaggat cagacaacta caattaaaaa agcgcgcatc atgtctcttg aggagtctct 1460161 agagtactta aacgaagatg aatattgtga agtaacacct gaatccatcc gtttaagaaa 1460221 gaagatcctc aataagaacg aacgtgaaaa agcagctaaa aagaaaaaaa cagcaggatt 1460281 gtcttaatct cgtgcagaat ttgaaaagat agaacccgta cgtttacagg ggagggaatc 1460341 tttttgaatg acgtaagcga acgcctgtcg ttcttcgccg ctctatatca agtagaccgg 1460401 cagcctgcgg caggcatgtg gctgctgtac ggcacgattt ttgtgttggc cgttattgta 1460461 tttaagcttg gatttgctaa acggcttcct gtattaaaat ctgcagtggt gtatgtattt 1460521 ttggctttgg gctgcactgt tttgactttt ttaggggtgt ttttgcccgt ggcagaagga 1460581 ttggtcgtcg ctgcgctgat tttaatcatt tacaaaatcc ggctgtatca gtcgaaaaaa 1460641 ggacagtctg caaaatcata aaagactcag ctgaaagctg agtctttttt gtgttctgta 1460701 tggttaagcg gccgctttat tttttgactt tttctttttt ctgctgtccc gggtgaaaag 1460761 taaattttcc cgttttcagc cgttcctctg tttttttggc aatccgatcg tggcattcct 1460821 ggcacatata tgtatggatc gggcggtttc gaagccgttt cgcgatcagg gtatcatcat 1460881 caattgtttc aattttatcg caaatagaac atttgaccct catcatatca cctctttcac 1460941 taacatgtat tataccacgg atcagaagct gtccaaaata agaaaaagct aaagcgcaag 1461001 gctatagctt agtcattgtt gttctttttc atatgatgat cagattgatc gttttgttcc 1461061 ttctccattt cctgttgctg ttttctattt aattggtcat tttgctgctt tgtttgcggt 1461121 tcatcttcat tgtcaatcac atcgttaggc acttcgggaa gcactcggcc gacaattgca 1461181 gctaattcat ccagtatacc tgttaccgga tggccctcgc tgatttctct gctcatttcg 1461241 cgaaggcggc tgaccgtatc gggatcagca atgactactg cgttggcgcc atatcgatca 1461301 ttctttagcg cctgagctac agaatattta atggtttcca ctttgcttct gtccaaagta 1461361 tcatcgacat caatcccaac aacagcatag cctcccagca caacggctgt tgcatccttg 1461421 acgtcggggt ttttttcagc aacgctgaca agatgcttgg caatatccgt tcttgttcca 1461481 ttgtcttttg tttcttgagt tgtgtccttt acgtgaatcg gtttagtctc ctgctgtctt 1461541 gttgattctt tttcaacatt ctggccctgt tttccttgtt gataggcaca agcggacagg 1461601 ataagtgtca gctgtatgat aatgaaaaga attcgcactt gcgggttccc tccttaaaat 1461661 gctttcatta attttattgt tgaattaacc ttctatcttt atgcacaaaa acatatattt 1461721 tagcaggcat tcaccttttt catcaaaaga gaagcaggaa gaactttgac ccttatatca 1461781 ggaggctgag acttgagtaa aatttatgtg ttagatacga atgtgttatt acaggatcct 1461841 aacgcgatat tttcttttga agaaaatgag gttgtcatcc ctgctgtcgt tttagaagag 1461901 gttgattcaa aaaaacggta tatggacgaa gttgggagga atgcaaggca cgtatctaag 1461961 ctaatcgatg cgctaagaca aaagggcagg ctgcatgagc atgtaccgct tgacaccggc 1462021 ggcacactga gaattgaact gaatcatcgt tcgtttcacc agctgcaaga gatctttatt 1462081 gaaaagacga acgataatcg catattagcc gttgcgaaaa acttaagcct cgaggaagaa 1462141 accaaggaaa atggcaggcc ggttatcctt gtcagtaagg atgtactggt cagggttaaa 1462201 gccgacgcaa tcggactgct tgctgaagat ttcttgaatg accgggttgt ggacaatgat 1462261 gaaatgtaca gcggctataa agatttatat atcagccagc agctgttcag ctctttttac 1462321 gggaaaaatc aaatttcagt aaacgatgtg aaacagcatg cgttttatcc gaatcagttt 1462381 gctttaatga aggatgagct aggagggtcc tcctcggcag tcggaattgc agacaaaacc 1462441 ggaacggtat taaaaagact cgtatttgat gatgaacata tatggggaat caggccgaaa 1462501 aatgtacagc agacaatggc attagagctt ttgctgcggg aagatattcc gcttgtcacc 1462561 ctgatcggca aagcgggaac cggcaaaacg ctcttagctt tggcggcagg gctattacag 1462621 acagaagact tgggaatata taaaaagctg gtcgtcgcaa ggccgattgt tcctgttggc 1462681 aaggacatcg ggtatttgcc aggcgaaaaa gaggaaaagc taaagccttg gatgcagccg 1462741 atttttgaca acttagagtt tctgtttaat gcgaaaaaac caggggagct tgatgctatt 1462801 ttggcgggaa ttggctcaat tcaggtagag gcgctgactt atatcagagg gagaagcatt 1462861 ccagatcaat ttattatcat tgatgaagcg caaaatttga ccaggcatga ggtgaaaacg 1462921 ttgctgacga gagtcggtga gggcagtaaa attgtcttaa tgggcgaccc tgaacaaatt 1462981 gatcacccat atttagacag tctgaacaat ggtttggcct atgtggttga gcggtttaaa 1463041 ggacaaccca tctcaggcag cgtgaagctg ttaaaaggtg agagatcagg tctcgcccag 1463101 cttgcagctg atttgctgta acacttaaat gatttcgatc tcttttacat cggtaatcgg 1463161 ctgtttgtga tgaaccgggt cttcaaagta aatatgcacg gggccgcctt cttgaatcgg 1463221 cttgcctgcc tcactgaaat ggacaatact gttcagagcg gtttccagag aaacggcggc 1463281 ctttcccgaa cttgtgacaa atacacattg tgtcgcagag ctgttcggct cagcattttt 1463341 caggacagtc ccaagtctca ttgcgaaact gccgttcatc agtttttgct tctcatattg 1463401 cttttccgtc tttaatgtag gcggcgcgat tcgcccctct ctgatgacgc gttccggatc 1463461 aaggtcggat tcatccccgg ctgattgtaa atatgtgtct tgactgtccc ctttgcggtc 1463521 aaacgaaaat ttgcgatcat caaaaatcca tacgcttgga tcaatggtaa ttggatatgt 1463581 aacattgcct tttacttgga taacgctcat gatatgaccc ccttctctca aaattataaa 1463641 agttttcgca tgaattgtca ctttgtgtac aaattatgtg tattgaaatg ctgagggaac 1463701 gagggtgttt gcatggtatg ccagcataat gatgagcttg aagccttagt gaaaaaggcg 1463761 aaaaaagtaa cggacaaggg ggaggtagcc agctatattc ccgccttggc aaaagctgat 1463821 aaacacgacc tgtcagtggc gatttattat tccaataatg tttgtctgtc agcaggtgac 1463881 gtagaaaaaa catttacgct tcaaagtata tcgaaagtcc tttcccttgc tttggtgtta 1463941 atggaatacg gcaaagataa ggtcttcagt tatgttggac aggagccgac cggtgatccg 1464001 tttaattcaa ttatcaagct cgaaacagtg aatccgagca agccgttaaa ccctatgatt 1464061 aatgccgggg cattggtagt gacaagtctg ataaggggaa gaacggtaaa agagagactt 1464121 gattatttgc tttcttttat cagaaggctg acaaacaacc aagagattac atactgccgg 1464181 gaagtggctg aatctgaata cagcacttca atgattaatc gggcgatgtg ttattatatg 1464241 aagcagtacg gcatttttga agatgatgta gaggcagtaa tggatttata tacgaagcaa 1464301 tgcgcgattg agatgaacag cttggattta gcgaaaatcg gatctgtatt cgcattgaac 1464361 ggcagacatc cagagactgg ggagcaggtc atctcaaaag atgtcgctag aatttgcaaa 1464421 acgtttatgg tgacgtgcgg aatgtacaat gcaagcgggg aattcgcaat taaggtcgga 1464481 attcctgcga aaagcggcgt atccggcggg ataatgggca tttcgcctta cgatttcggg 1464541 atcggcatat tcggccccgc attagacgaa aaagggaaca gcattgcagg tgtaaagctt 1464601 ttggaaataa tgtctgagat gtacaggctg agtatttttt aatttatgtc atatgcttaa 1464661 atcctcttgc attttctgtt gatacccttt atgataaata gaagaattag gtactcgcct 1464721 ggggaacgga gggatacttt tggcttcaga gatgatagtt gaccatcggc aaaaagcttt 1464781 tgaactctta aaagtggacg ctgagaagat tttgaagctg atccgagtac aaatggataa 1464841 cttaacgatg cctcaatgtc ctctatatga agaggtttta gatactcaaa tgttcgggct 1464901 ttcgagggaa atcgattttg ctgtccgcct gggattggtt gatgaaaaag acggtaaaga 1464961 ccttttatac acattggagc gcgaattgtc tgctttgcat gacgcgttta cagctaaata 1465021 aatgataaaa ctcaaactta ttaacagttt gggttttttt ataaccgcta tttttctctc 1465081 atctcataaa agacggtctt tttttacaca ttccttccga atcgtataga gattcttcgt 1465141 ctcgtttgat aaattgtagt aaaataaaaa agataaatac ataaaaacca tagataatgg 1465201 aagttagaag cagggaagag gatgttatgt taaaaaaaat gctaaaatct tatgattact 1465261 cactgatatt cgcaatcgtt ttattatgcg gattcggttt agtgatggta tacagctcaa 1465321 gcatgattac ggctgtctcc cggtatggag taagcagtaa ttttttcttc atgcggcagc 1465381 tgtttgcttt aattgcgggt ggcgctctat ttattctcat ggcgttgttt ccttataaag 1465441 cactggccca tcaaaagttt cagaagggga tactgcttgt atctgttctt gcgcttatct 1465501 cactgtttgt tttcgggcat gttgccggaa acgcgcagag ctggtttaaa atcggcggaa 1465561 tgagtattca gccgggggag tttgtgaaac tggtcgtgat tttatacctt gcagccgtat 1465621 atgcaaaaaa acaaagttat atcgaccatc tgttaacggg agtagcccct ccggtagtca 1465681 tgacgcttat aatttgtggg ttaattgcca tgcagccaga tttcggtaca gccatgatta 1465741 tagggttaat tgcgacgtgc atgatcttgt gctccggctt cagcggaaag acgctggtga 1465801 ggcttgtgat actgggcgga attgttttca ttttagtcag ccctattatc tatttgaatc 1465861 aggacaaaat tttaactgaa ggccgtttag cgcgttttga gagtcttgaa gacccattta 1465921 agtatgcaaa ttcatcaggt ttgcaagtga tcaattctta ttatgcgatc agctcaggcg 1465981 gcattttcgg cctggggctc ggtgaaagta tccaaaaata cggatatctg cctgaatcac 1466041 acactgactt tattatggct gtcattgctg aagagctcgg catttttggg gtattgtttg 1466101 tgattttctt attgggtttt gtcgtcataa aaggttttta tattgccaga aaatgcgagg 1466161 acccgtttgg aagtcttctg gcgatcggca tttcaagcat gattgccatc cagtcgttta 1466221 ttaaccttgg cggtgtcagc ggattaattc cgattacagg ggttacgctg ccatttatca 1466281 gttacggggg ctcttctttg gtgctgctgc tggggagtat ggggatatta gcgaatatca 1466341 gcatgtttgt gaaatattca gagaataaga aaaagaaaga gcccttggcg ccgaagggaa 1466401 tgaaaaagaa acagctcaaa aaaactgttt atctgtaaaa aacaagtgtg tacaggggaa 1466461 ggatattccg ctatgataga ttatattcca ttcgggtaag ggggagaaaa gtttgtctca 1466521 gcaatcgata caaaaagtat tagtagcaaa caggggagaa attgcaatcc gaatattccg 1466581 ggcgtgtacc gagttgaata ttcgtacagt tgcggtctat tcaaaagaag attccggttc 1466641 ctaccatcgg tacaaagcgg atgaagcata cttggtcggt gaagggaaaa aaccgattga 1466701 tgcttacctg gatattgaag gtatcattga tattgcgaaa agaaacaaag tcgatgcaat 1466761 tcatccggga tacggtttct tatctgaaaa tattcatttt gcgagacgat gtgaagaaga 1466821 aggcatcgta ttcatagggc caaaatccga gcatctcgat atgtttggtg acaaggtaaa 1466881 agcgcgtgag caggcagaaa aagcgggaat ccccgtgatt ccgggaagcg acggtcctgc 1466941 cgaaacgctt gaagccgtcg aacaatttgg acaagctaac ggttatccga tcatcattaa 1467001 agcctcgctt ggcggcggcg gccgcggtat gcggattgtc agatctgaaa gtgaagttaa 1467061 agaagcatat gagcgtgcta aatcagaggc gaaagcagcc tttggcaatg atgaagttta 1467121 tgtagaaaaa ttaattgaga atccgaaaca tattgaggtt caggtcattg gagacaagca 1467181 gggcaatgtc gtccatcttt ttgagaggga ttgctccgtt caaagacgcc atcaaaaagt 1467241 cattgaagtg gcgccgagtg tctcgctgtc acctgaatta agggaccaaa tttgtgaggc 1467301 tgcagttgcg cttgccaaaa atgtaaacta tataaatgcg gggacggtcg aattccttgt 1467361 tgcaaacaac gagttctact ttattgaagt aaatcctcgc gtacaagttg aacacacgat 1467421 aacagaaatg attactggtg tcgatattgt tcaaactcag atccttgttg cccaagggca 1467481 cagccttcac agcaaaaaag taaatattcc tgagcaaaag gacattttta caatcggcta 1467541 tgccattcag tcacgggtta cgactgagga tccgcaaaat gatttcatgc ctgatacagg 1467601 aaaaatcatg gcttaccgct caggcggcgg ttttggtgtc cgtcttgata ccggaaacag 1467661 cttccagggc gccgtgatca caccatacta tgattcactt ctcgttaagc tttcaacttg 1467721 ggctttaacg tttgaacagg cagctgccaa aatggtgcga aaccttcagg agtttagaat 1467781 cagaggcata aaaacgaaca ttccgttcct tgagaacgtt gcaaagcatg agaagttcct 1467841 gacagggcaa tatgatacat ctttcattga tacaacgcct gaattattta atttccctaa 1467901 acaaaaagac cgcggaacga aaatgctcac ttacatcggc aatgtgacag tgaacggctt 1467961 ccctggaatc gggaaaaaag aaaaaccggc gtttgacaaa ccgttaggcg taaaggtaga 1468021 cgttgatcag cagcctgcca gaggaacaaa gcaaattctc gatgaaaaag gtgcagaagg 1468081 gcttgcaaat tgggttaagg agcagaaatc tgtcctttta actgatacga cattcaggga 1468141 tgcccaccaa tcgttattgg caactagaat cagatcgcat gatttgaaaa aaatcgcaaa 1468201 tccgacggct gcgttatggc ctgaactatt cagtatggaa atgtggggag gcgcgacctt 1468261 cgatgtagcc taccgattcc tgaaagaaga tccgtggaaa cgtttggaag atcttcgcaa 1468321 agaagtgccg aataccttat tccagatgtt gcttcgctca tcaaatgcgg tcggctatac 1468381 gaattatccg gacaatgtga ttaaagaatt tgtgaagcaa tcagctcaat ccggtattga 1468441 tgtgtttcgt attttcgaca gcttaaactg ggtaaaaggg atgacgttag ccattgatgc 1468501 tgttagggat accggcaaag tggcagaagc tgcgatttgt tatacgggag atatccttga 1468561 caagaaccgg acgaagtacg accttgcata ttatacatcg atggcgaagg agcttgaggc 1468621 ggccggagcc catattctcg ggattaaaga tatggcaggg ctgttaaaac cgcaggctgc 1468681 atatgagctc gtttctgcgt tgaaagaaac gatcgacatt ccggttcacc ttcatacgca 1468741 tgatacgagc ggaaacggta tttatatgta tgcgaaagct gttgaagccg gcgttgatat 1468801 catagacgtg gcggtcagct caatggcggg attaacgtca cagcctagcg cgagcggatt 1468861 ttatcatgcg atggaaggca acgaccgccg tccggaaatg aatgtccaag gcgttgaatt 1468921 gctgtcccaa tattgggagt cggtgcgtaa atattatagt gaatttgaaa gcggaatgaa 1468981 gtctccgcat actgaaattt atgaacacga aatgccaggg ggccaataca gcaacctgca 1469041 gcagcaagcc aagggagtag gccttggcga ccgctggaac gaagtcaagg aaatgtacag 1469101 acgcgtgaac gatatgttcg gtgacatcgt caaggtaacg ccttcctcaa aagtagtcgg 1469161 agatatggca ctctacatgg tgcaaaacaa tctgactgaa aaagacgttt acgaaaaagg 1469221 tgaatcttta gatttccctg attctgtcgt ggagcttttt aaaggaaata tcggccagcc 1469281 tcatggcgga ttcccagaaa aactgcaaaa gctgatctta aaagggcagg agccgattac 1469341 agtcagaccg ggcgaactgc ttgagccggt gtcatttgaa gcgatcaaac aggaatttaa 1469401 agagcagcat aacttggaaa tttcagatca ggatgctgtg gcatatgccc tttatcctaa 1469461 agtcttcact gattatgtga aaacgacaga aagctatgga gacatctcgg tattagatac 1469521 accgacattc ttctacggta tgacattagg tgaagagata gaagttgaaa ttgagcgcgg 1469581 caaaacgctg atcgttaagc tgatttcaat cggtgagcct cagcctgatg ccacccgcgt 1469641 cgtttatttc gaactcaacg ggcagccgcg tgaagtagtc attaaagatg aaagcattaa 1469701 gtcttccgtt caggaaaggc tgaaagcaga ccggacaaat ccaagccaca tcgcagcttc 1469761 catgcctgga acagttatta aggtattggc tgaagcaggc acaaaagtca ataaaggtga 1469821 tcatttgatg attaatgaag cgatgaaaat ggaaacaacg gttcaggcgc ctttctcagg 1469881 aacaatcaag caggttcatg tgaaaaatgg tgagccgatc caaacgggag atctgctcct 1469941 tgaaattgaa aaagcataaa aaacaaagag tgtatatcaa tgatatacac tcttgttttt 1470001 tatatagaaa atgtggagtg aaacagatgg ttagaagaga tataagggga cttcagagat 1470061 tatagagtac tgtcacaagc ccaaaataaa aagaggctta tacagccaat attttagatg 1470121 ctttgtagta tgccgtgcat atttctttaa gcactatctg atttaaaagg ctttaatact 1470181 tatgttcgcg agctatagat ccatatgaaa tttctataat cacgatgaga aaggggacag 1470241 accgaagtga gccgctcact gatcatcaag ttcggcgaag gctggcgatt gaaacgcata 1470301 aagcgccaaa aaacaagaca taaaaaagac caaagccgcc taaggctttg gtcttgagtc 1470361 cttatgattg cctggattca taacggaaac gagcaatcaa taataagaag tagcatagaa 1470421 cgccaaacag acaggcaata aagaacgagt gggcaagtgc aaagcccaga gccagttcag 1470481 agtatacgat cataataccg gacagtgcct gtaatgtaat gaaaataaga catgagatcc 1470541 atccccaaaa gatctgtttt tgatctttat aggaagtaat agcatgaaca gcggcaacaa 1470601 taatccatac aaataaaagt aaggctgctg ctctgtggcc catttgcacc cattcatgga 1470661 attgggtcgg aagtccattg ttcagcgggc tgcacagcgg cacattagga catgccagac 1470721 ttgattcagt gtgtcttaca tatgcgcctg tatacacaac gatataggaa tatattaaaa 1470781 ttcctatcat gtgaaattgc atctttttgc cgatttgaag cggcttaacc agtgttctga 1470841 ctgatttatc agcttcaaat atgagcaatg ttaaaataag cactgaagca aaagaaatta 1470901 atgagatgcc gaagtgaagc gccataatca gcgcgttcga accgaatacg acagccaatg 1470961 cgccaagcaa tgcctgaaga aataaaaaga taattgacat gatcgcgaga aacgttgttt 1471021 cacgaaaaat cggcgtgatt tttctccatg accaaaacgc aaggcttagc acaaggataa 1471081 tagagattcc gcttgcgaat cggtggctcc attcaataat tgaagccgga ttcagttcag 1471141 ggaaaaaacg gccgtgacac agcggccact gtctgccgca tccttggccg gaacctgttt 1471201 ttgtaacgag ggcacccccg attaaaacaa ttagcatgac aaatgtcgtc agaacaccga 1471261 gagcttttaa tgctttattc atacaatatt caccttctta acatactgct gcaattttat 1471321 atacgttcca agtgtaagcg aatatgtgtt ttgtggcaat tcccagagcc ttttgttcac 1471381 aaaaatataa tagaatgacg gcttctggaa aatgtacact tgattattca tgccgggtct 1471441 gatagaaata aggtaaacgc aatgccgatt tggagattgc cttcatcttt ggtaaaattc 1471501 ataaaaagtt cacaaataaa ttcctgtttg tcgtttaata tttaatagga tgttttttta 1471561 caagatgtta tcttgtatga tagagttgca ggttatttta ttctcctgcg ttaggtttgt 1471621 aagggaggtt tacgttatgg ctaactccag aatcttaaat gatacagcta tagacggaca 1471681 aattgaagaa acaacggcat ggaaagattt tctgtccctt attaaaatag ggatcgtcaa 1471741 ttctaacctc atcacgactt tcactggaat gtggcttgca ctgcatatat ccggtttaag 1471801 ttttttaggc aatataaaca ccgttcttct tacgttaatc gggtcttcac tgattattgc 1471861 gggctcctgc gcgatcaata actggtatga ccgggacatt gaccatctta tggagcgtac 1471921 gaaagtaaga ccgacggtta cgggtaaaat tcagccgagt caggcgttat ggtctggaat 1471981 tttgctggtt gctttaggat tgatcatgct gctgatgaca actgtcatgg ctgctgttat 1472041 cggttttatc ggagtcttta cgtatgttgt attgtacaca atgtggacga aacgccgcta 1472101 tacgattaac acagtagtag gaagcgtttc cggtgcagtg ccgccgctta ttggatggac 1472161 ggcagtggaa gggaatatcg gtgtcgtagc atgggtgtta ttcatgattt tatttatttg 1472221 gcagattcct cacttcttag cattggctat taagaaaact gaggattaca gagctgcaaa 1472281 tattccgatg cttcctgtcg tatacggatt tgaagtgaca aaaagacaaa ttattgtgtg 1472341 ggttgcgtgc ctgatgccgc ttccgttttt ccttggtagc ctgggtcttc cgattgtcat 1472401 tctcggcttg ctgttaaata tcggctggct gattcttggc ttaatgggat tccgctccaa 1472461 gaatatcatg aagtgggcaa cgcagatgtt cgtttactcg cttaactaca tgacaatcta 1472521 tttcgttgcc atggttgtct tgacgctttt ctaaaaaata gatatgatgc ttgttttatc 1472581 gcttcaaaat aaacgatgac aactagtaaa tgccgccttg acctcttgtt taatcaggcg 1472641 gctttacttt tatacataga tggcattttg agtaaaaaaa ctcataattt aagagaagag 1472701 gaaatgtaag tgctttattg gtgataggtt ggatggcgat agatttcgat ccgctttccg 1472761 cctttgtatt gaccagaaaa ggggttgggt gaaatggtaa agcattggcg tcttatttta 1472821 ttattagcct tagtgccgct tctattaagc ggatgtggaa aacctttttt atccacgctc 1472881 aagcctgctg gcgaggtggc tgataaacag tatgacctga cagtgctcag cacattgatt 1472941 atggtggttg ttgttgcagt agtatctgtt atcttctttt atgtgattgt gagattcaga 1473001 agatcacggg tcggtgagaa cacgataccg aaacaggtag aggggaataa atttttagaa 1473061 atcacatgga ccgtgatccc gattttgctg ctcattattc ttgtgattcc tgttgtatta 1473121 tatacgctgg agctagcgga cacatcacca atggataaaa aaggccgcaa agctgaggat 1473181 gctcttgtag tcaatgttag ggcaaattta tactggtggg agtttgagta ccctgattac 1473241 ggcattatca caagccagga gctgattgta ccgacagatc agcgtgtata ttttaattta 1473301 aaagcctctg atgtaaaaca ttccttctgg attccttcag ttggaggaaa acttgatacg 1473361 aatacggata atgaaaataa gttcttcctg acatttgatt caaaacgaag caaagaggca 1473421 ggagatatgt tttttgggaa gtgtgcagag ctttgcggcc cttcacatgc gctgatggat 1473481 tttaaggtga agacgatgtc tgcaaaagaa tttcagggct ggacaaaaga aatgaagaac 1473541 tataagtcta cagcagagag cgatttggct aagcagggtg aagaactgtt taaagagaaa 1473601 aactgcctga gctgccatgc ggtagagccg aatgataagc gtgcagaagc cgctagaacg 1473661 gcacctaact tggcgacctt cggtgaaagg acaaaagtgg caggggtgaa agaggccaac 1473721 aaagaaaatg tgaaggcttg gctgaaggac cctgacagca taaagccggg gaacaaaatg 1473781 acaggcacat atccaaagct ctcagacagc gaaacaaatg cgctttatga atacttaaaa 1473841 ggcttaaaag cggaaagcaa gtagggaaga aagggagata ttgggggagg tcacatatgt 1473901 tgaatgcgct tacagaaaag cggacgcgcg gatctatgct ttgggattat ttgacgacgg 1473961 tggaccataa aaaaatcgca attctttatt tagtggcagg gggattcttc tttcttgtcg 1474021 ggggaattga agcgatgttt atcagaattc agcttgcaaa gccggaaaat gcgtttctca 1474081 gtgctcaagc gtacaatgaa gtaatgacta tgcacggaac gacgatgatc tttctggctg 1474141 cgatgccgct cttatttgcc ttgatgaatg cggttgtgcc tttgcagatc ggggctcggg 1474201 acgtttcgtt tccattttta aacgcgcttg gtttttggct cttctttttc gggggcattt 1474261 tcttaaatct aagctggttt ttgggcggag cgccagatgc gggctggaca tcatatgcct 1474321 cactttcgct tcattctaaa gggcacggca tagacttttt cgtcctcgga ctccaaatat 1474381 cggggctcgg gacgctgata gccgggatta actttttggc cacgattatc aacatgaggg 1474441 ctccgggcat gacgtatatg aggctgcctt tgtttacatg gacgacattt gtggcctcgg 1474501 cattgatttt gttcgcgttt ccgccgctta cggttggatt ggctctcatg atgctggatc 1474561 ggctgttcgg aaccaatttc tttaatccgg agcttggcgg aaatacggtc atttgggaac 1474621 atttattttg gatcttcggc cacccggagg tttatatcct aattttgcct gcattcggta 1474681 ttttttctga ggtcatccct gtgttcgcca gaaagcgttt gtttggctat tcttcaatgg 1474741 tttttgcaat cgtgctcatt ggctttctgg gctttatggt ttgggtgcac cacatgttca 1474801 cgactggtct cggcccgatt gcaaatgcga tttttgcggt tgcaacaatg gctatcgcga 1474861 ttccgaccgg gattaagatt tttaactggc tgttgacgat ttggggagga aatgtgaagt 1474921 atacaaccgc tatgctgtat gctgtctcat ttattccatc ctttgtgctc ggcggtgtga 1474981 cgggagtcat gctggcagct gctgcggctg attatcagtt tcatgatacg tattttgtgg 1475041 ttgcgcactt ccactacgtc attattggcg gcgttgtatt cggcctttta gccggtgttc 1475101 atttctggtg gccgaaaatg ttcggtaaaa ttctgcatga aacgatgggg aaaatttcat 1475161 ttgtattgtt ttttatcggc tttcacctca cgtttttcat tcagcatttt gtcggcttaa 1475221 tggggatgcc gcgccgggtt tatacgtttt tgccaggaca gggtctggaa accggcaact 1475281 tgatcagtac aatcggggcg ttttttatgg cggcagctgt tattcttctg ctggtcaatg 1475341 tcatatggac atcggtaaaa ggtgaatatg taggtgctga tccatggcat gacggacgta 1475401 cgctggaatg gaccgtttct tcaccgccgc cggagtataa ctttaaacag cttccttttg 1475461 tcagaggact tgatccgctt tggatcgaga agcaggcagg gcacaaatca atgacgccgg 1475521 cggaaccggt tgatgatatt catatgccaa acggctcaat cctgccgctc atcatttcct 1475581 tcggcctttt tgtcgcagcg ttcgggctgc tgtacagaag tgattacgct tggggcctgc 1475641 cggtgatctt tatcgggctc ggcatcacat ttattacgat gctgcttcgt tcagtaattg 1475701 atgatcacgg ctatcatatt cataaagagg aactgccgaa cgatgataaa ggggtgaagg 1475761 cataatgcaa gttcaagaaa aattcaccgc agaaaccttt ccagcttctc ctgaaaaagt 1475821 aaccctggaa gggaaaaata aatttttagg cttttggctt tttcttggcg gagagactgt 1475881 tctgtttgcg tctctcttcg ccacgtttct tgcgcttcgg aattcaaatg ccggtgatcc 1475941 gcctacgacg gaaatgttcg atgtgacact tgtattcatt gccacaatgc ttctattaac 1476001 gagcagttta acgagtgtgt acgcgatgta ccacatgaag aacttttcct tcggcaagat 1476061 gcagctttgg ctgggaatta cgattttatt gggggcgggc tttttaggac tggaaatcta 1476121 tgagttcaag cattacaccc atgaatttgg ctttaccatc acaagctctg cccttggttc 1476181 tgcgttttac acgcttgtcg gtacacacgg cgcccacgtg gcatttgggc ttatgtggat 1476241 cagcacgctt atgatccgca atgccaagag agggctgaat ctgtatacgg cgcctaagtt 1476301 ttacgttgcc agcctttatt ggcactttat tgatgtcgtg tgggtcttca tctttaccgt 1476361 tgtatattta atggggatgg tgggataaac atggtcgata aaaaaagcag agggcatatc 1476421 aatagcgacc ttgaatttaa gaaaaaaaag catgcccggg agatgaaata tcaagtcctg 1476481 tcttttggtt taatgatcgg tcttacgatt gttgcatttc tgactgtggc cacggacggt 1476541 gtcggcagct ggtttacgat tcctttcatt attttgctag ctgcaattca agtcattttt 1476601 cagctgtatt atttcatgca tatgaatcag aaagggcatg aggcgccggc actgtttttg 1476661 tattcagggg tgtttgtcgc gtttatcact gtgcttgcgt ttgtgacaat tatatggtgg 1476721 taatttgaac agccgccgga ggtgaagaaa tgaatcagtt ggagatattt gggtttcgcg 1476781 cgatgtggag cccttatctt ttttgtatcc tgttaggcat tacggcgctt tatctctatt 1476841 tttacaggcg aatgtcttca aagccgaatc gaataactgg taaagagatg gtgtgctttc 1476901 tgtcggcgat gctgttttta tatgcagccg agggaagccc ggttgatctg ctcggacata 1476961 ttatgttcag tgcgcatatg gtgcagatgg ccgtcctgta tttggttgtc ccgccgctgt 1477021 taatcgcggg gattcctgca tggctctggg aaaaaatcat tttcaggcct tcaatcaaac 1477081 cggttttttc cttttttacg acgcctttaa ttgctttgct tttgtttaac ggcatttttt 1477141 ctttatatca tgtaccgctt atatttgata ctgtcaaaac agatccgttt taccatacat 1477201 taatcacttg gcttatcttt gtgcttgcgt tcttcatgtg gtggccgctt gttcataagg 1477261 ttgagcgtct acggcagctc agcggcttga tgaagctggg ttatattatg gcggacggta 1477321 tgctgctcac acctgcttgc gccttgatca tgttcagcgg tgcaccgtta tacgccacct 1477381 atacagatcc ggctttatgg gctgaggcaa tgaggctttg cgtgccagcg gatatgatgg 1477441 ggcaggtccc attaacaggg ccagagatgt tgaatacact gcctttgtta gaggatcagc 1477501 agctcggagc agtcatgatg aaaatcattc aggaaattgt gtacggtact tttttggccg 1477561 ttattttttt ccaatgggtg aagaaagaaa gggaaaagga cgggcaggag gagccgccgt 1477621 atattcagca gacgatatca taaaaggtac agcgaaatat gctgtacctt ttcgttacat 1477681 ttgaactgtt tttaacatgt tggctatgtc ctgaatcagt gccttgcttt ttgtcacaac 1477741 ctgtacggga aactcttccg tttctccata ttctactcca tgagggtagt aatgctttcc 1477801 taggagaggg gacattaatt gaatcacggc gcgcccgctt ccgacatcgc cttctgccgc 1477861 aataccttgt atccgcaggt aaaacgtacc ctcaatcgtc gaaaacttct tgtcataggt 1477921 gactctctcg taatcccatt gacccgctct gataagacct ttgctttcca ttaagtcgtc 1477981 tagccagctg agctcagcct taaccccttc aagtccgctt tcagtaaact tcaacactga 1478041 cccctcctta taaaaattac ctttcctgac aatcatagta tgaaagcgtt aaactttcaa 1478101 tgaatcttct tcttttgaaa gtatgcaaaa attaaatttt gacgacaata gcactagact 1478161 aaaggaggtt aaacggatga caaaaataaa agatctgatg acagccgact tgcaatattg 1478221 cacggtatta gataatgtat atgaagctgc agtaaagatg aaggacgcaa atgtaggagc 1478281 gataccggta gttgatgagg acggggaaac attggtcggc atcgtaaccg accgcgatct 1478341 cgtattaaga ggaatcgcca tcaaaaaacc gaactcgcaa aaaatcactg acgcgatgac 1478401 tgaaaaacct gtcagtgtgg aggaagatgc ttcagtcgat gaggttcttc atttgatggc 1478461 atcgcatcag ctcagaagga taccagttac aaaaaataaa aaactgactg gaattgtcac 1478521 gcttggtgat ctttctttat ctgagcaaac gaatgaacgt gccggcagcg ccttatcgga 1478581 tatttccgaa ggggataata gagaagaagg cttttttcat taacacataa atctttgaca 1478641 tgttaaatag gctgtattgt aatgggatgt aaacaagaga ttgtgaatcg ccacgggggt 1478701 gatagattga aaaatatatt gagagcaatg gttatccttt tgattatctg cggaacctat 1478761 gttctgttta ttcaatatgg atctgttcct gaaaagaaat caaatgacag cgagcctcag 1478821 gtgtcgaatg aggaagcgca aagcggcaaa cgaatacata tgccgacttc agggttattg 1478881 tccttcatgg gcaagcacgc cgatgaagta acgaaaaagc ttggggaacc tgaacgtatt 1478941 gacccttcgg cttatgatta cgattggtgg gtatacaatc aaggtaagga tcaatatatc 1479001 caaatcgggg tattaaacaa taaagtggtc acattattcg cgtcgggtaa tgatattaac 1479061 gccaagcctt tcaaaattgg agaatcaact ggcgaagtat tcaagaccac ccaggtggca 1479121 ccatttgtga atgtagagta taaaggaaat tcctatcggt ttgaattttc tgaagaagat 1479181 atcaatacaa gaccgactgt aaaggtagga aagatgtatg tccagctgta tatggacaaa 1479241 tttgagggga agctatccag catcagggcg tttgatgcgc agacctttgt aaagcaaaga 1479301 ccttatgagg tagtgtaccg cggggaatta attaaaccga aagccgtttc agatgagaaa 1479361 tggaaaaaga tccaaacaac gagcgaaaag caaatccttg atttgacgaa tgtcatacgc 1479421 gttaaacatg gacttgcgaa gcttgagtgg gatcagccaa cggcggaagt ggcatttggg 1479481 catagtgagg atatgaagga aaataattat ttctcccatg tctctaaaaa atacggctcg 1479541 ctgaaagacc gcttagaaga agggcatgtt gattttcagc aagcgggaga aaatatcgca 1479601 tacaattatg tggacggtcc ggctgctgta gaaggctggc tgaatagcga aggccatcga 1479661 aaagcgcttc tgaattcaga ttatacgcat cttggtgtcg gagtagaccg gaaatattac 1479721 acccaaaact ttattaagcg atggtaatga aagccgcgga cgaatggttc ccggcttttt 1479781 ctatttccat acaagctggt ctgaatgaat gtgctgatag cttacagata aggccgtttc 1479841 ccatcccttc agtcaggctt tttcaccagt gtatagggat atcgctaaaa attcatttgg 1479901 gaatgaatat aggcgaacac aatgcccgac aaaacgatac attgtagtag gtaacgattt 1479961 tcggaggggg tgaggattgt ggcgaatcaa catgccaatc attcaatcaa tgactttaaa 1480021 caattcgtca aaaagcatcc caagctgata aaagaagtgc gcaaagaaca aagaagctgg 1480081 caggacgtat atgaaaattg ggtcctcttc ggggagagcg acccgatttg ggatccatat 1480141 cgggaaccgg aagaagcttc tgaagctgtg cctgaaacac cgcaaaaaaa tgattttgtc 1480201 tcgaaaatgg tgacagcggt gaaaaagatg gatgtcaatc aaatgaacga acaaatcaat 1480261 aaaatgagcc agtcgatctc atcgttgcaa agccttctta atacattttc cggaagcgga 1480321 cagaagcatt ctcagccagg ctctggacag catccttttt cttttcgaaa ggattaaaaa 1480381 aggggagctc atatgcgcaa agaggttcag gaatatattt tagcaaacga agaacggaaa 1480441 cgattcatca gagaacagcc gatatggtac cgcaggcttt caagaaaacc ggatgatctg 1480501 tcctcctttc agcttgaaat gatgaatttt tatgaaaaaa ccattccgca tcgggtgaat 1480561 cagtttacga acgggattca aatggcgcaa atgatgatgc aaatgtttca agcgatgcgg 1480621 acaaaagatt aaaaggcccc gaagaagggt cttttttcat gcggtcataa ggttttgttg 1480681 gcggctgcgg ttaagcattt tccaattggc tggtttcatg gtaaactaac aactggaggt 1480741 gcatgttatg tatgcgacga tggaatccgt gcggcttcaa agtgaagctc agcagcttgc 1480801 cgagatgatt ctgcagtcgg agacggctga gaactaccgc aattgttaca agcgtctcca 1480861 ggaagatgaa gaggcaggtc ggattattcg ttcttttatc aaaataaaag agcagtatga 1480921 ggatgtacag cgttttggca aatatcatcc tgactataga gaaatatccc ggaaaatgag 1480981 ggagatcaaa cgtgagctgg acctgaacga taaggtggct gacttcaaga gagctgaaaa 1481041 tgagctccag tccattcttg atgaggtcag cgttgagatt gggacagctg tttcggagca 1481101 tgtgaaagtt ccgactggga acccttattt tgacggtttg tcttcatgcg gaggcggctg 1481161 cggttcaggc ggaagctgcg gatgtaaagt gtcctgacga gactggccgt ctcgtctttt 1481221 acatataaga gaaaacaggc aggtgattgt attggagaat aggcgccagg gcatggttgt 1481281 gtatctgcac tccctaaagc agagcaaaat gctgaggaag ttcgggaatg tgcactatgt 1481341 atcaaaacga ttaaaatatg tcgtactgta ctgtgatatg gaccaaattg aaaaaacaat 1481401 ggacaagatt gcgtcttact catttgtgaa aaaagtggag ccttcttata aaccgttttt 1481461 aaaattggaa ttcgagtcaa agcttgataa ggcaaaagaa tacgattata aaatcggcat 1481521 atagctataa aaaaatcccc gcaggcatct gcggggtcct tctattcctt aatatgttaa 1481581 ggagaaggca aagggagagg agaaaccgga ggaagaactt atggggaaac gtaagtcttc 1481641 tccgcggttg gcaacaacat cctctagatg ctgttgctta tagtatggac aaggatcatg 1481701 ctgcctatac acctgtttat caagattagc gttcattgtt tggaagaatg ctttatgtta 1481761 agataggatt gatttttttc tatgtacata gcggcgtccg gccgaataaa gaaacaaaat 1481821 agcttttaga aaaagtggtg tggaacatga gagtaatttc tggatcaaaa aaaggccgtt 1481881 cactaaaggc tgtagccgga acatcaacaa gaccgacaac cgacaaagtg aaggaatcca 1481941 ttttcaatat gatcggccct tattttgacg ggggcagggg acttgactta ttcgcaggga 1482001 gcggaggtct tggaatcgaa gcgctttcac gcgggtttga gcattgtata ttcgttgacc 1482061 gtgattttaa agcgattcaa acggtaaaat ctaatttgaa aacgctggag cttacaaaac 1482121 atgcacaggt ataccgcaat gatgcggaac gtgctttgca cgctgctgct aaaagagaaa 1482181 ccggctttcg cggaattttt ctcgatccgc cgtataagga acaaaagctg aaagcacttt 1482241 taactttgat tgacgaatat caaatgctgg aagaagacgg ctttatcgtc gctgagcatg 1482301 acagagaggt cgagcttccc gaaaccgtag gagatcttgt gatgacaaga aaagaaacct 1482361 atgggttaac aggtgtagcg atttataaaa agagggggta gtgaggtggc gagtatagct 1482421 gtctgtcccg gcagttttga tcctgtgacc tacgggcatc tggacatcat caaacgcggg 1482481 gcgcatattt ttgaacaagt gtatgtatgt gtgctgaata attcttcaaa aaagcctttg 1482541 ttcagtgtgg aagaacggtg tgagcttctg agagaagtca caaaagacat tccgaacata 1482601 acagttgaaa catcgcaagg cctgttaatt gattatgcaa aaagaaaaaa tgcgaaagcg 1482661 attttaagag gcttgagagc tgtatctgat tttgaatacg agatgcaggg gacatcagta 1482721 aaccgggtgc ttgatgaatc tattgagacg ttttttatga tgacaaacaa tcaatattcg 1482781 tttctaagtt caagcatcgt aaaagaagtg gcaagataca acggctcggt atcagagttt 1482841 gtaccgccgg aagtagagtt ggcgcttcag caaaaattca gacaaggatg agggttttga 1482901 ctcatccttt ttttgttccg tttgtcagtc tgtaagaaaa aatgataatg tacgtaaaca 1482961 gcgcgcatag tgtgacagca ggtccgatct gcacaagcag attccagccg tttataaagg 1483021 cagttgacat gtcactgctg ttaagagatt taaatacata ctgatacgga tcatgccatg 1483081 ctgtgtaaag aggtttccat aaaagcatga cgaagacagc ggcataaacg ccctgcagca 1483141 aacgtgcgat aaagaatggt ttaaatctaa tgtcggtttc cgataaaata cctgccacct 1483201 gagcttgtac ggaaaagccg ctaaacccaa gaataaagct gacgataatg gctttttgca 1483261 gaagagaaac atctgtctcg ctgacaagct tgctgcctaa tgtaatttca aacatccctg 1483321 ataaaagcgg aatgtccaat tgagtcggaa gctgaaacaa agtcagtgct ccttttgtga 1483381 aaacagacaa aacatcagtc agctggacca ctgacaacag ccgattgaag acagaaaata 1483441 aaataataaa gccgcctacc ataagaagcg tttgaacaga agacgtcacg gcgtcgccta 1483501 aaattttacc taagggccgt ttttctgcaa gtctggcggt atgaagagcg tgtaaagcat 1483561 ctttgactga agggaaaggt atcgttttct ttcttctgag atgctgctct tccttgcggc 1483621 cataggagcg cattgttaaa ccgacggcaa gattccccaa atagtgtgca gaagctaata 1483681 aaatgcctag tgatgcgttt tgaaagaaac cgacggcaac agcgccgaaa ataaagagcg 1483741 ggtttgaaga attggtaaac gacgcgagcc gttctgcctc tactcttgaa atctgatttt 1483801 cctgccgcag acgggcagtg agttttgcgc ccgctgggtt tcctgatgcc attcccatag 1483861 caagaacgaa gccgccgaca cccggcacgc gaaagatcgg ccgcataaaa ggctcaagca 1483921 aaacaccgac aaaccgcaca atgccaaagc cgattaagag ttcggacaga ataaaaaatg 1483981 gcagcaatga cggaaacaca acctcccacc acatagacag cccggtttta gaggcttcga 1484041 atgaggcctg tggatgtgag atgacagtcg ctgttaaaaa aagaaaaaac gaggcaatca 1484101 aaagtgtatt aatcttcgac aagttcattc ttacctcccc gatgctaaaa atgcccaatg 1484161 acatgtatat catgataaaa taatgtatga tgtaaaacgg ccaagcagta cctgtcctct 1484221 tgattctttg tactaatata cgagcatagg ggttcagttt agaccataga attcggtata 1484281 cagggaattc aggcaggagg ttaacgcttt ggccaaacct aaaatcgggt tagcgttagg 1484341 atcgggaggg gccagagggc ttgctcatct cggtgtgctt tccagtttac ataagcacca 1484401 aattgaagtg gatatgattg caggaagcag catgggcgct ttggtgggca gtttttacgc 1484461 cgccggacat gacgtggcaa cgatgaaaaa agtagccaaa gcctttaaac gaaggcttta 1484521 tgctgattat acggtgccga aactcggttt tttaaaaggt gaccgcgtca gacagcttgt 1484581 gcatgcttat acattcggaa aaccgattga agagctccaa atcccgctgg gcattgttgc 1484641 gtgtgatcta cagacgggag aaaagattgt gttccgaaaa ggatcagtgt cagatgcagt 1484701 gagggccagc atcagcatcc cgggtatctt tattccgcag cggctggacg gacgccttct 1484761 tgtagacggc gcggtcgtcg atcgaattcc ggtttctgtt gtgaaagaca tgggagctga 1484821 tattatcatc gcttcggatg tttccagggt tcgaaaaact gaaacagcag tgcatatttt 1484881 tgatgtgatt atgcaaagta tggatatact gcaaaatgaa ttagtgcggc atcaaacaat 1484941 tgccgcagat atcatgattc gcccttccct tgaaacatac agctcaagct cgtttgccaa 1485001 tattgaagaa atgatatcgg caggcgaaga ggcgacaaac cgaatgatca gcaagataag 1485061 aaaagaaata gagaattggg agggctcata atttgctacg taaaaaacat tttagctgga 1485121 tgctcgtcat cctcatactg atcgccgttt tatcatttat aaaacttcca tactatatta 1485181 caaaaccggg agaagcgaca gagcttgctt cattgataaa agtggaggga ggctacccgg 1485241 aaaaaggaag tctgtcctta atgactgtta aagtgggacc ggctaatcca tttacatatg 1485301 tgtgggcaaa gatgcaccct tattatgaaa ttgttcctga tgagagcatt aaggaggaag 1485361 gcgaatcaga taaggagtat atgaaaagac agctccaaat gatgaaaagc tcgcaagaaa 1485421 atgcggttat agccgcctat caaaaggcag gaaaaaaagt cagctattcc tttaacggca 1485481 tatacgcaag ctcagttgta gaaaacatgc cggcaaaagg gaaaatagaa gtcggtgata 1485541 aaatcatcag cgcagacggc aaaaactatc agtctgctga aaagctgatt gattatatca 1485601 gcagcaaaaa agcgggagat aaagtcacgt taaagatcga aagagaagaa aaagaaaagc 1485661 gtgtcaccct tacgttaaaa caatttcctg atgagccgga tcgggcagga atcggagttt 1485721 cgctttatac agacagaaac gtgaaggtag agcctgatat tgattttgaa atcgaaaata 1485781 ttggcggccc gtcagcaggg ttaatgatgt cccttgaaat ctataatcag ctgacaaaac 1485841 cagacgaaac aaaaggctac gatattgcgg gaacaggtac gattgatgtt gacggaaaag 1485901 taggcccgat cggcggcatt gatcaaaaag tcgtcgccgc agacaaagcc ggaaaagaca 1485961 ttttcttcgc gccaaatcaa aacggcgcca gcaattccga ttataagaac gcagtaaaaa 1486021 cagcaaaaga tattgattca aatatgaaga ttgtgcctgt tgataccatg caggatgcga 1486081 ttgattattt gaataagctg aaagcgaaaa gcacctgatt ctcaggtgct ttttctatac 1486141 atttaaaaag tgttgttcat cttcgtcata tcgaatcggt gcatgtccgt attcctgtag 1486201 gtcaaactca gttctcagcg gctcttctat cggcaggctg taaatcctgc ttgcttttac 1486261 gtccagatcg agagctggat gggagaaaga ggacagtttg ctgacaagcg gaacagacag 1486321 tgcttttttc ttttcggata aataagcctg tccttttttc gtcatgccga gaagcctgat 1486381 atacggcgcc ttatcgttgt caagcagctt ttgcatatcc tgtttttttg ttctggttaa 1486441 aatgtgtgta ttcatccgct ggagccttgt ccacgtatag cgttttgttt tcagcagttc 1486501 cataaattcc tgataggagc tggattttct gatcgaacga ataattctgt gctctaaacc 1486561 ttcctccacc tcgtatactt gctgtaattc ccgtgccgtt acagttgaaa ggctgtattt 1486621 taagtaagaa aagtagcttt caggtgtatg ccacaatccg aaagatttgc ggtaagctgc 1486681 taattcacgt gcagatgcag cagggagaaa acgaaggcag gcttcgagat tctggccaat 1486741 catcgctttt ctaatgcttg tggcacttgc tatatggttt tcgccttcag ggagatcggc 1486801 atcatgatag tccgaagaga ttcgtgccgt agtataaggt ttcataggat atcccccggt 1486861 tagaatcgag gtcacatact ggtatcccaa aatgttattt ggttttgaca agtcaagtgc 1486921 actttcagta tgcaaaatgg agctgaaggc gatagccgcc gctgctgggt aactggcccc 1486981 ctttttaagt tcttctttaa ttcggtcatt caatatatgt ttatgctcat caataagctg 1487041 tgctgtttct aaaaaaggct tgatatcccc attttcactc ccgaaaaaca gcgcctcaca 1487101 ttcaagttcg ttcaggatgg aaacactgcc gcgtgcaaaa atgtctgctt tttgcacggc 1487161 ataaagataa ggcagctcaa tgacaagatc aactccgctt tgcagcgcca tttttgttcg 1487221 ggcccatttt gatacaacag cgggttcccc gcgctgtaaa aaatgtccgc tcatgaccgc 1487281 gacagccgtg tcacatccgg tttgcagctt tgctgtttgg gcatgataaa ggtgaccgtt 1487341 atgaaaggga ttatattcaa ccaccaatcc gacagctttc atattttttc cgcctttctt 1487401 gctatgttta aaaacgtatg gtacatttgc aaatgaaaac tcttacgcct tatttttgtt 1487461 ttaagtgtat gcatagcata ttccgctgtc aacgatactt caatggcagc attatgctgt 1487521 aaagaaaaaa tattgacaaa aacaatctta aaagctataa tcatgtttgt tgctttcctg 1487581 aggtgataca aatgaaatgg acgatttatc agctgcatca aatgccaaaa caaagttttg 1487641 agtttgatga aacagttgag ttaaatgagc tgacaaagct gaattctgac attcgccgca 1487701 tttctcccgt tcgggtgaag ggcagagcgg atatcaaatc caaacaggtt tcgtttgatt 1487761 ttacaatttc aggcgaaatg cttttgccat gctcaagaac actcgttgat gttccgtatc 1487821 catttgaaat ttcaacaaaa gaactgttta tatttcatca cacggatgat atagaagatg 1487881 atgacgttca cattgttgag gacgatacta tcgacataac tccgatcgtg aaagaagaaa 1487941 ttcttttaga aatccctatg caaatctttt gtgaatctga acaagaaaaa ggagctgctc 1488001 ctcaagaagg aaaggattgg caagtcattt cggaagaaga caagaagaat caagttgatc 1488061 cgagacttgc agcccttgaa aagctcttaa aacaagatga tgaatcttaa ctctttaagg 1488121 aggtgggaat aatggctgta ccttttagaa gaacttctaa aatgaagaaa agattgcgcc 1488181 gtacacattt caaacttaat gtacctggta tgacagaatg tccgtcatgc ggagagatga 1488241 agttgtctca ccgtgtatgc aaagcatgcg gatcatacaa cggcaaagac ataaatgtaa 1488301 aaagtaacta atgagaaaag cgcagggtga aagccctgcg ctttttcttt ttctcttcct 1488361 gtcagcttgc ggaaaatttg tgagtgcaaa tagtctatct aatctattac cggcatatgt 1488421 atgagataaa taagctgaca tggagggaga ttgaatttga ccattacaag acaagatgct 1488481 tggactcagg atgaggattt gctgctggca gaagtggtgc ttcgtcatat tcgagaggga 1488541 ggaacacagc tttcagcctt tgaggaggtt ggaagggcgc tgaccagaac cgcggcagcc 1488601 tgtggtttca ggtggaactc gtatgtgaga aaacaatacc agtcaggtat agagcttgca 1488661 aaaaagcaaa ggaaagaact gagaaagcaa atcggcgttc attcggtcaa tatgccgaat 1488721 tccatgaagc agactgcctc ggcatcgtca gaaggaaaac gagatttgtc cattcaggat 1488781 gtcattcaat ttctcgaaca attcaaagaa acaccgtctg cacaagaatt tcagcttgaa 1488841 agggaaaaat tgaaggagca aatccaatcg ctgcaaaaag agcttgagga tttgcggagt 1488901 gaaaatcaga cattgcggaa tcagctagag atgacagaag aggattacaa ggcactgatc 1488961 gatatcatgg atcgggccag aaaaatggtt gtttcgaagg aagacggaag aatgaaaaaa 1489021 gcggctcaag aaacgtaaag aaacgcctga aatgaaccgg ccctatagta agaataggcc 1489081 ggttgttttg atttctatgc agactctccc ggtgtcattt cgcgatccat atcaggatgc 1489141 cagatgagcg ggttttcccc tttgtcccgc gccatatcat acttaacagt tttaaagttc 1489201 attttgttcc aaaattccgc tgatttcatt ctcggatttg tccggatcgg cattttgaat 1489261 gattttgcaa attcaaccaa ggctctcccg tatcccctgt tctggtagcc cggaagaacc 1489321 tcaagcttcc acagctccaa ataatcctgg cggttgtcaa aatagggatt cgatttgccg 1489381 ttaacttgat acagactcat tcgtgctaca agtttatcgc caaaataaat cccgtaaaaa 1489441 ggcgaggtgc tgtcattttc aataatatta tcctgaagtt cttcaagcat tgaaagctcc 1489501 tgaatgccgt attctttgaa tttcttgaat tcttccagcg ttttatagtt gataagcaga 1489561 cgttctacct ttgtcaaaca aatctccccc tttgttgttt ctacatatat tgtaaacgct 1489621 ttatttaaaa aatccaaata tttaaacttt aattttaagc acatgggatc tttgagaagt 1489681 aatttcttct tacttctgct atgataatac gtaaatgcta aattgggtgt gacatcatga 1489741 aaattggaat tatcggcgga ggctccgttg gtcttttatg cgcctattat ttgtcacttt 1489801 atcacgacgt gactgttgtg acgaggcggc aagaacaggc tgcggccatt cagtctgaag 1489861 gaatccggct ttataaaggc ggggaggaat tcagggctga ttgcagtgcg gacacgagta 1489921 tcaattcgga ctttgacctg cttgtcgtga cagtgaagca gcatcagctt caatctgttt 1489981 tttcgtcgct tgaacgaatc gggaagacga atatattatt tttgcaaaac ggcatggggc 1490041 atatccacga cctaaaagac tggcacgttg gccattccat ttatgttgga atcgttgagc 1490101 acggagctgt aagaaaatcg gatacagctg ttgatcatac aggcctaggt gcgataaaat 1490161 ggagcgcgtt cgacgatgct gaaccagacc ggctgaacat cttgtttcag cataaccatt 1490221 cggattttcc gatttattat gagacggatt ggtaccgtct gctgacgggc aagctgattg 1490281 taaatgcgtg tattaatcct ttaactgcgt tattgcaagt gaaaaatgga gaactgctga 1490341 caacgccagc ttatctggct tttatgaagc tggtatttca ggaggcatgc cgcattttaa 1490401 aacttgaaaa tgaagaaaag gcttgggagc gggttcaggc cgtttgtggg caaacgaaag 1490461 agaatcgttc atcaatgctg gttgacgtca ttggaggccg gcagacggaa gctgacgcca 1490521 ttatcggata cttattgaag gaagcaagtc ttcaaggtct tgatgccgtc cacctagagt 1490581 ttttatatgg cagcatcaaa gcattggagc gaaatacaaa caaagtcttt tgagcttttt 1490641 cggtaacatg ctatactcat ttcggatcac taactattta ttggagaaag gaagttctag 1490701 aagatgcagc taactgaact ttccatcaaa aatcagaatg tgtttgtaca gcactatata 1490761 gatggcaaag aagaaatgtc ttcttttttt gattacagta ttcatcataa ggacatgtgg 1490821 cgcgaaagac tggaagactt atcttcccgg tttttcgcaa gagaggaatt ggcggcgtac 1490881 ttaacctctt accataataa attcggttca agtgcgatgc agtctgctat tgagaagctg 1490941 aaggacccgt caagtgccgc tgtagtcggc ggacagcagg caggactttt aacaggaccg 1491001 ctttacacca tacataaaat catttcaatc attgttttag caaagcaaca agaaaaggaa 1491061 ctgcaagtgc ctgtcatacc aatcttctgg gtggctggag aagaccacga tttggatgag 1491121 attaattttg ttcacacatc tgaagagaat gggcctgtga aaaaaaagct gcctcagtct 1491181 tattggaaga aatcatcagc agcgagtaca tcgcttgatc aggaaaagtg tgccgcgtgg 1491241 atagatgatg tttttgccgc ttttgaagaa acagaccata cgaatacact tctcgacaat 1491301 gtgaaacgat gtttaaggga atctgttacg tttactgact tctttgaact gctgatcgcg 1491361 gatttgttcc aagaagaggg cttagtttta ttaaattctg gggatccggg gattaaaaag 1491421 ctggaaacgg ccatgttcca aaagattctt cgagaaaatg atgaactcgc ccgggctgta 1491481 tcagatcagc aggccttcat gcgtcaagca ggctacaaac cgattatcga gtccggaaaa 1491541 gagcaggcga atctgtttta tgaatacgaa gatgagcgtt ttttaattga aaaagataac 1491601 ggccgatttg tcatcaaaga gcttgatcta ggatggacga gggatgaact tcatacacat 1491661 atggaagaac atccagagcg tttcagcaac aatgttgtaa cgagaccgtt aatgcaggaa 1491721 tttctcattc cgactttagc atttattgca gggcctgggg aaatcaatta ttggggcgag 1491781 ctcaaacagg catttgcggt gatgggcttc aaaatgcctc ctgtcatgcc aaggctgaac 1491841 attacgatac ttgagcggca tattgagaaa aaactggctg aacggaatat ctcattacaa 1491901 gacgcgattg agcgcggaac ggagaatcaa agagagacat acttcgagcg ccagattccg 1491961 gaagagttta cggcggtgat ggatcaggcg aaaagccaaa ttgaagcgat tcacaaaacg 1492021 gtccggcagg aggcgttaaa ggttgatcaa agcttggaac ctttacttct gaaaaatgcc 1492081 gcttttattc aggatcagct tcaattctta gagcgcacgg tgatgaagcg aattgaagaa 1492141 aaagaaggct acgtcttgaa ggattatgaa agaattcaaa atagcattaa gccgcttctt 1492201 gcgccgcaag aacggatttg gaatatcatg tattatttga acaggtacgg tccaaaattc 1492261 ttcacgacat tcaagaatct gccattttct tttcaaaatc aacatcaagt tgtcaaactt 1492321 tgaaataaag ttttaaagaa ccctgactag ttcagggttt ttttttatgg gtaaacagtg 1492381 taaaatgaag ttgtggagcg aagtggtgaa tagtggtgag ttaaggagag aaagtggggc 1492441 aagagatcat gtttatgggt gaatatcagc ataccatcga tgcgaaaggc cgcatgatcg 1492501 tacccgctaa attcagagaa ggcctaggtg agcaatttgt gctgactaga ggacttgacc 1492561 aatgtctctt cggctaccct atgcacgaat ggaaacaaat tgaagaaaaa ctaaaagctc 1492621 ttcctctcac aaagaaagat gcccgcgcgt ttacccgttt cttcttttca ggggcgactg 1492681 aatgcgaact ggataagcaa ggcagggtaa atatcgcatc atctctattg aattacgcca 1492741 aactggaaaa agaatgtgtt gttatcgggg tttctaatcg aattgaattg tggagtaaag 1492801 taatttggga acaatacaca gaagagcaag aagattcatt tgctgaaatt gctgaaaaca 1492861 tgattgggtt tgatatataa tgattcttcg tgtataacac tctaaaaaca atttcaattc 1492921 atcctgataa aaggtgggac caacacaata tgtttcaaca caagacagta cttcttcgtg 1492981 aaaccgtaga cggacttaat attaaaccag acggtacata tgtagactgc acactcggcg 1493041 gagctgggca tagtacatac ttattgcagc agttatccga gaaggggcgt ttaatcgctt 1493101 ttgaccaaga tgatacggca ttacagcatg ctaaagaagt gttgtccgat tataaaggac 1493161 agctcattct gattaaaagc aatttcaggt atttaaaaga atatttgaat gaacaaggcg 1493221 ttacagaagt agacggcatt ttatttgatt taggggtgtc ctctccgcag ctggatacac 1493281 cggagcgcgg attcagttac catcatgacg caccgttgga catgaggatg gaccagtcgg 1493341 ctacgctttc ggcgaaagaa gtcgttaatg agtggcgcta tgaggatctc gtccgtattt 1493401 tctttaaata cggagaagag aagttcagta aacagatcgc cagaaaaatt gaggaggcaa 1493461 gaatgaagtc tcctattcaa actacgggcc aactggtcga tctaataaaa gacgcgattc 1493521 ccgctccagc gagaaggagc gggggacatc ccgctaaacg cgtgtttcag gcaatcagaa 1493581 ttgccgtaaa cgatgaactt agggtgtttg aagaagcttt ggagcaggca attgaggttc 1493641 tgaagccagg gggcagggta tcggtcatta ccttccactc gctagaagac agaatttgca 1493701 aaaccacttt taaagaaaag tcgtcgcttc cggaacttcc tccgggactt cctgttatac 1493761 cggaagagtt tgaaccggag ctgaagctca tcacacgaaa accgattacg gcatctcaag 1493821 aagagcttga agagaacaac cgggctcgtt ctgccaagct tcggattgct gaaaaaagaa 1493881 aataacgaaa cgcgaacgca aaattaaaag gaggtcatca gcctatgagc aatttagctt 1493941 accaaccaga gaaacagcag cggcatgcga tcagtcctga gaaaaaagtg attgtcaaga 1494001 aaagggcttc cattactctc ggagaaaaag tgcttcttgt cctctttgct gcggcggtgc 1494061 tcagcgtatc gcttttgatc gtatcgaagg cgtatgcggc atatcaaacc aatattgagg 1494121 tgcaaaagct tgaggagcaa atttcatccg aaaataagca aattggtgac ctcgaaaaaa 1494181 gcgttgctga tttaagcaaa ccgcagcgca ttatggacat tgcgaaaaag aacggcttga 1494241 atttaaaaga taaaaaagtg aaaaacatac aggaatgatt caaatgccaa aaaagaataa 1494301 atttatgaat agaggagcag cgattctaag tatttgtttc gctctctttt tctttgtcat 1494361 cctggggaga atggcatata ttcaaataac cggaaaagcg aacggcgaag tgcttgcgac 1494421 aaaagcgaca gagcagcatg aaaagaaacg gaccatcgaa gcgagccgcg gctcgatttt 1494481 agaccgaaaa ggaaaagtca ttgcagagga cacagcgacg tataaactga ttgcgattct 1494541 cgataaaaaa atgaccactg atgtcaagca tcctcagcat gttgtaaaca aagaaaaaac 1494601 ggcggaagca ttgtctaaag tgataaactt ggacaaggcc gacatccttg atatcttaaa 1494661 taaagatgca aaacaagtcg agtttggctc agctggccgg gatattacgt attcacaaaa 1494721 gcaaaaaatc gaaaaaatga aactcccggg catttcattt ttacgggata caaaacgcta 1494781 ctatccaaac ggagtatttg catctaatct aatcggctat gccgaggttg atgaagaaac 1494841 aaatgaaatt tccggcgcga tgggattaga aaaagtgctg gataagtatt tgaaggagcg 1494901 ggacggatat gtgacatatg aaagcgacaa atccggctgg gagctcccga acagcaaaaa 1494961 taaaattaca gcgccaaaaa atggtgacaa tgtatattta accattgacc agaaaattca 1495021 aacctttttg gaagacagca tgacaaaagt ggcgcaaaag tataatccga aaaaaatcat 1495081 ggccgcagtc gttgatccga aaacgggcaa agtccttgcc atgggacagc gcccaagctt 1495141 tgatccgaac aagcgcgatg tgacaaacta ctataatgat ttgatttcat atgcgtatga 1495201 acccgggtcc acgatgaaga tctttacact cgctgctgcg atgcaggaaa acgtgtttaa 1495261 tgcgaacgaa aaatataaat cagggacatt tgaagttggc ggagcacctg ttaaggatca 1495321 caataacggt gtaggctggg gtccgacaac atatcatgac ggcgtcctaa ggtcgtcgaa 1495381 tgtcgctttt gcgaaactgg cgaaagaaaa gctgggatat gaccgcctca atcaatattt 1495441 gcacaaattc aatttttacc agaaaacagg tattgatttg ccaggagaag tctccagcaa 1495501 aatcaacttt aaatatgaat ttgataaggc gtcaactgca tatggccaag cgtctgcggt 1495561 cacaccaatt cagcagattc aggccgcaac ggcaattgca aatgacggta aaatgatgaa 1495621 accttatgtc attgaccata tcgttgaccc tgataaagat aaaactattt atcaaaataa 1495681 gccggaatca gccggaactc caatttctgc aagtactgcg aaaaaggtgc gggatatatt 1495741 aggagaagtc gttacatcga agatcggaac agggcaagct tataaaatcg aaggttttga 1495801 tgttgccggg aaaacaggta ctgcgcaaat agccggtaaa ggcggatatt tagacggcac 1495861 agataactat atcttttcgt ttatgggtat ggcgccaaaa gatgatcctg agcttttaat 1495921 ttatgttgct gtacagcagc cgcaactaaa agcaggacaa agcagttcag atccagtatc 1495981 agaaatcttc aatccaacaa tgaaaaatag cctgcactac ctaaacatcg aaccaactga 1496041 aaaatctgac tcagataagg aagaaacaaa agcgcagaca atgcctgatt taacagatca 1496101 aacggtagct gctgctcaaa agaaagcaaa agaggagaat ctcacaccaa ttgtcatcgg 1496161 cagtgatgtc gctgtaaaag aacagtatcc gaaagcggat gaggaagttc tcaccaatca 1496221 aaaggtcttc ctgaaaacgg gcggcaaaat caaaatgcct gatatgacag gctggtcgag 1496281 aagagaggtt ctgcagtacg gcgagctcgc gggaattcat attgaagtaa gcggacaagg 1496341 ctacgctgtc agccaaagtg ttaagaaaga caaagaaatc aaagacaaaa ccgtaatcaa 1496401 ggttaagttt aaaaatcctg attaaaaaga aagccgtcgt tatgcaggct ttcttttttt 1496461 atgccttcag aggagcatcg ttctacctgt ccaaattcag gcataaaatg aaacaagcct 1496521 aaataaggag tgaacggtct cttgcgcgtc tcgaatgtaa cggttagaaa acgtttatta 1496581 tttgttttgc tttttggcgt gatcgtgttt ctgatcattg atacaaggct ggggtatgtt 1496641 cagtttgtga tgggcgaaaa actgacttcg ctagcgaaag attcctggag ccggaacttg 1496701 ccgtttgagc cggagagagg cgagattctg gatcggaatg gtgtgaagct cgcaacaaat 1496761 aaaagtgcgc cgaccgtatt cgtcgtgccg cgccaagttc agaatccgat gaaaacgagc 1496821 aagcagcttg cggcggtgct caatatgtca gaagaaaaag tatataaaca tgtgacaaaa 1496881 aaagcgtcaa tcgaaaagat cactcctgaa gggagaaaaa tttcaaatga gaaggcgaaa 1496941 gaaatcaaag cgcttgattt aaaaggtgtg tatgttgcgg aggacagtat ccgtcattac 1497001 ccgttcggca gctttttatc tcatgtgctt ggatttgcag gaattgacaa ccaagggctc 1497061 cttggacttg aagcctatta cgacgatgat ttaaaagggg aaaaaggttc tgttaagttt 1497121 tatacagatg ccaaggggaa gaagatgcct gatgaagcgg atgactatac gccgcctaag 1497181 gatgggcttg atatgaagct gacagttgat tcaaaggttc agacgataat ggaaagagag 1497241 cttgataacg ctgaggccaa atatcatccg gacggcatga ttgccgtagc catgaatccg 1497301 aaaaacggag aaattttggg gatgtctagc aggcctgact tcgaccctgc tgattaccaa 1497361 tctgttgatc cgtccgtcta caatcgaaat ctgccagtat ggagcacgta tgaaccggga 1497421 tctaccttta aaattattac acttgcagca gcccttgaag agcaaaaagt aaatttgaaa 1497481 cgggatcaat tttatgataa agggcatgct gaagtggacg gagcgagact gcggtgctgg 1497541 aaaagaggcg ggcacgggct gcagacgtat ctggaagttg tgcagaactc ctgcaacccg 1497601 gggtttgttg aattaggcga gcgcttagga aaggaaaagc ttttcaaata tatcaaagac 1497661 tttggttttg gacaaaaaac ggggattgat ctccaaggcg agggaacagg catcttattc 1497721 ccgcttgaga gagtgggccc ggtggagcaa gcaactacgg ctttcggaca gggagtatcc 1497781 gtcacgccga ttcagcaggt tgcagcagta tccgccgctg taaacggagg aacgctctat 1497841 acaccttata ttgcaaagga atggatcgat cctgttacga agaaaacggt caaaaaacaa 1497901 tcaccaatcg caaagaaaca agtcatttct gaggaaacat ccaaacaaat ccgctatgct 1497961 ctagaaagcg tcgtcgcaga aggaaccggc cgcaatgcat ttgtagaagg atatcgtgtc 1498021 ggaggaaaaa cgggaactgc acaaaaggtt aaagatggaa aatatcttga aaacaaccat 1498081 attgtatcat ttatcggttt cgcgccagca gatgatccga gtctagtcgt ctacgttgcg 1498141 gtggataacc cgaaaggcac gattcagttt ggcggaacgg tggcagcgcc tattgtcgga 1498201 aatattatga gagacagtct gccggaactt ggtgtgaagc cccggaaaaa tcaaatcgag 1498261 aaaaaatacc aatggaacga cacaaaaaca atagaagttc cgaatgttgt agggatgtct 1498321 gtctcagatc ttgagtcact attggtgaat ctcaatgtgg atgcttccgg gaaagggagc 1498381 aaaatcgtta aacaatcgcc agctgccgga acgaaagtaa aagaaggctc aaagatacgc 1498441 gtgtatttga ctgaagaaga tgaaaaggag gcagccgatt gattcgggct gcctattctt 1498501 ttattgcaga aaaaatgctg atatctttca agattagctg gatgtatcct tttatttacg 1498561 ctaaaatatg aactgtatgc ttaaaatcat taccacatca tttgatgtga cttcaatgat 1498621 aaaaagaacg aattagaatg ttgagaggtt tgatacgatg aaacttacaa agctgcttac 1498681 atacttaaca accgaacctt ctgtaaacga ctcacaagac cctgaaataa cttcaattga 1498741 gatggactcc agggaagtaa agaaagggag tctttttgta tgtgtaaaag ggtatacggt 1498801 ggatggccac gattttgcgc aaaaagcagt agaaaacggt gcagcggcta ttgtggcaga 1498861 aagagaggtc gatgtgaatg ttcctgttat tattgtccgg cagtcacttc gcgcgctcag 1498921 cgttttgtct gatgcgtttt acggacagcc gacgaagaag cttcagctga ttgggataac 1498981 agggacaaac ggcaaaacat caacgaccca catggtcgat gagattctga aaaaagcggg 1499041 aaaacgcaca ggcttgatcg gtacaatgta catgaaaatc ggagacgaaa cacttcctgt 1499101 taaaaacacg actccggaaa gcgtcacgct gcagaaaacg tttaagaaaa tgaatgacaa 1499161 gcacgttgac actgcaatca tggaggtttc ttcccacgct ttgtctttag gacgcgtcca 1499221 tggctgtgat tatgatattg ccgtgtttac gaatttaaca caggaccatc tggactatca 1499281 taaaacgatg gatgagtacc ggcatgcaaa aagcttgctc ttttcccaac ttggcggggc 1499341 tttcaaccat gaacatccaa agcgtgccgt cctgaatgct gacgatgagg cgagcgctta 1499401 ttttgaaaag gtaacagctg cgcatatctc tacatacgga attaaaaacg atgctgatgt 1499461 gatggcgaag aacatcagta tcactgcaca gggcacaagc tttgatctcg tgacaaacaa 1499521 aggcacgaag cacatcacga tgtctctcgt cggacaattt aatgtgtata acgtgctggc 1499581 cgctgttgcg acatgtattg cagcaggcat accgtttgaa atcatcactg aggctgttga 1499641 agaattgcat ggtgtaagag gccgttttga attggtcaat cagcagcagg agtttcctgt 1499701 cattgtagac tacgcgcaca caccggacag ccttgaaaat gtgctggaga catgcagaga 1499761 catgacggaa ggaaagctat ttgtcgttgt cggctgcgga ggagacagag ataagacgaa 1499821 gcgcccgaaa atggctaaaa ttgctgtgga gctggctgac gagccgattt tcacgtcaga 1499881 taacccgaga agcgaagatc ctcgcgcgat tttaagagat atggaagccg gagtagagaa 1499941 cgcatactat cacagtattg caaaccgcga gcaggcgatc tttttcgcaa ttgccaatgc 1500001 caaaaaaggc gacgttgtcc tcattgccgg aaaaggacat gaaacctatc agcagatcgg 1500061 aaatgaaact ttcgattttg atgatgctga agtagcggcg agagccattg ttgaactcaa 1500121 taagaataag acgaattcat aggaaagaga tgttactgaa taatggagct tgaaaagatt 1500181 tttcatatgg aaaaaaatca tgaatatgat aactacgtat gtcgtttgaa agaaacagga 1500241 ggagaaaagg acaatgcttg agcaagtcat tctgtttaca attttaatgg ggtttttaat 1500301 tagtgttctg ctctctccga ttcttattcc gtttttaaga agattaaaat tcggccagag 1500361 tattagagaa gaaggaccga aatcacatca gaaaaaatca gggacaccga caatgggcgg 1500421 ggtcatgatc atactttcta tcatagtgac aacaattgtt atgacacaga agttttcaga 1500481 aataagcccc gaaatggtgc tgcttctgtt tgttacgcta ggctacggtt tgcttggctt 1500541 tttagatgat tacatcaagg ttgtcatgaa gcgcaatctt ggattgacat caaagcaaaa 1500601 gctgatcgga caaattatta ttgcggttgt attttacgcc gtgtatcatt actacaattt 1500661 tgcgacggat attcgcattc ctggaactga cttatcattt gatcttggct gggcttactt 1500721 tatccttgtg ctctttatgc tagtcggcgg atcaaacgca gttaacctga ctgacggcct 1500781 tgacgggtta ttatccggta ctgcggcgat tgcctttggc gcctttgcca ttctggcatg 1500841 gaatcagtct caatatgacg tagcgatttt ctcagttgcc gttgtcggtg cagttctggg 1500901 cttccttgta tttaatgctc atccggccaa agtttttatg ggagatacgg gatcgcttgc 1500961 attgggagga gccatcgtta ccattgccat tttaacgaaa ttagagatcc tgctggttat 1501021 catcggcggt gtattcgtta tcgagacatt atccgttatt ttgcaggtca tcagctttaa 1501081 aacgacaggt aaacgaatct ttaaaatgag tccgcttcat caccattatg agcttgtcgg 1501141 ctggtctgaa tggagagtag tcgtgacgtt ttgggctgcg ggacttttgc ttgccgtttt 1501201 aggaatttac atcgaggtgt ggttataagt ggaaaatgat caatttttac agaaacagca 1501261 ttttttaatc cttgggcttg cgaaaagcgg atatgcggcg gcctccattc ttcatgaaaa 1501321 aggcatttat gttgcagtca atgatcaaaa gccttttgaa gaaaatgaac cggcacaaaa 1501381 gctttctgaa aaaggaatcg aagttgtttg cggagagcat ccagtttctc tgttcgatca 1501441 gcatcaaatc acgattctga tcaaaaaccc gggaattcct tatgaaaata tcatggttca 1501501 ggaagcagag aaacgaggta ttccggtttg gacggaaatt gagctcgctt actacctgac 1501561 cagcgccaag tttatcggga ttaccggatc gaacggtaaa acgaccacga caacgctaat 1501621 ttacgaaatg ctcaaggctg actcgcaaaa agcactgatt gccggaaaca tcggcacagt 1501681 cgcaagtgag gttgcctatc atgctgatgg agatgaatgg atcgttaccg aactgtcttc 1501741 gtttcagctg atgggaacac acgctttcag accggaaatc agcctgattt taaatgtatt 1501801 tgacgcccat ctggattatc accatacgcg cgaaaactat gaaaaagcga aacagaaagt 1501861 gtaccttcat cagactgctt cagataaagc tattgtcaac caggatgatg aaaccgtcgt 1501921 gcgtcttgct gaagccggaa aagccgaaat cgtcccattt tcagtcagca aaacgcttga 1501981 acagggcgca tatgtaaaag acagtatgat tatgtttaac ggcgaagcca ttcttcctct 1502041 ggaagaggtt gtactgcccg gtgctcataa cctggagaac attttagcag ctattgcagt 1502101 tgtgaaaacg gcaggagcat ccaatgaggc ggttaaaaag gtgctgacaa gctttactgg 1502161 tgtgaagcac cgcctccaat atgtcacaac tgtgaatggc cgcaaatttt ataacgacag 1502221 taaagcaaca aacattctgg cgacaagcaa ggcgctttca gcttttgata agccggtcat 1502281 tctgcttgcg ggcggactgg atcgcggaaa tggttttgat gacttgaaac cttatatgaa 1502341 gcatgtcaaa gcagtgctta catttggcca gacggcgcca aaactcgaga aactcggcaa 1502401 tgaactggga atacaacatg tcaaacgtgt cgataatgtt gaacaagcag tatctgcggc 1502461 gtttgcgctc tcaaatgaag gagatgtcat cctgctgtca cccgcgtgtg cgagctggga 1502521 tcaattcaaa acatttgaag aacgcggtga catgtttata gatgccgtgc atatgcttaa 1502581 gtaagggctt gtcttgaagt aaatcggcag ccctaatgac tttaagcttg gggtgtcgat 1502641 tgctttgact actaaaaaaa catcgcctga tttgttattg gtcatcatta cgttattatt 1502701 attaacaatc ggattaatta tggtgtacag tgcgagtgcg gtatgggcgg attataaatt 1502761 tgacgactca ttctttttcg cgaaacggca gcttttgttt gcgggaatcg gcgtcattgc 1502821 tatgtttttt atcatgaatg ttgattattg gacttggagg acatggtcca aattgctgat 1502881 ggttatctgc tttttccttc tggtgcttgt tttgataccg ggcgtcggaa tggtgcggaa 1502941 cggttcaaga agctggatcg gagtcggagc attcagcata cagccttcag agtttatgaa 1503001 gcttgcgatg attgcattcc ttgctaaatt tctctctgaa aaacaaaaaa acatcacatc 1503061 gttcagacgg gggttcgtcc ctgcacttgg catcgtgttt tcagcatttt tgattatcat 1503121 gtgccagcct gacctcggaa cggggacagt tatggtcgga acttgtattg tcatgatttt 1503181 tgtagccggc gcacggatcg cccatttcgt ctttctcggg ctgatcggcc tcagcggatt 1503241 tgtcgggctc gtactatcgg ctccatatcg gataaagcgg attacctcat acttaaatcc 1503301 atgggaagac ccgctcggaa gcggatttca gatcattcaa tcgctttatg cagtggggcc 1503361 cggcgggttg ttcggaatgg ggctcggaca aagcagacag aagttctttt atctgcctga 1503421 gccgcaaaca gactttattt tcgccatctt gtcagaggag ctgggcttta tcgggggaac 1503481 acttattttg ctcctcttca gcgtcctgct gtggagagga atcagaattg cgcttggtgc 1503541 gcctgatctg tacggaagct ttgtcgcagt cggcattatt tcaatgattg ccattcaagt 1503601 catgataaat atcggcgtag tcacgggcct gattcctgta acaggcatca cgctcccgtt 1503661 tctgagctac ggaggctctt cattgactct aatgctgatg gcagttggtg tgctgctgaa 1503721 tgtaagccgc tactcgaggt attaacgaat gtatttccaa gcctcctgtc taacatgaag 1503781 cttggaaaca attgatgcga taaccctgtc caacaaaaca gggttatcgt tatgttatag 1503841 agaaacttag actgggggaa aaaagaaatg cgaattgcaa taagcggagg cggtacaggg 1503901 ggacatattt atcctgctct tgcttttatt aaagaagtgc aaagacgtca tcctaatgtg 1503961 gaatttttat atatcggaac agaaaacggg ctggagaaaa aaattgttga gcgggagaat 1504021 ataccgtttc gttcaattga aattacagga tttaaaagaa aattgtcatt tgaaaatgtc 1504081 aagactgtga tgcgttttct gaagggcgtc aaaaagagta aatcgtattt agcggaattt 1504141 aagcccgatg ccgtaattgg aacgggcggt tatgtatgtg ggccggttgt ctatgccgct 1504201 gcgaaaatgg gaattccgac tattgtccac gaacaaaaca gcctgccggg catcacgaat 1504261 aagtttcttt caaaatatgt taataaagta gcgatttgtt ttgaagaagc gaaatcacat 1504321 tttcctagcg agaaagttgt atttacggga aacccgagag cctctgaagt cgtctcaata 1504381 aagacgggac gatcattggc tgaatttggg ctttctgaag acaaaaaaac ggtcttaatt 1504441 ttcggcggaa gccgaggcgc tgcaccgatt aaccgcgctg tcattgacat gcaggatgtg 1504501 ctgaaaacaa gagactatca agtgctgtat atcaccggtg aagttcacta tgaaaaagta 1504561 atgaatgagc tgaaaagcaa gggtgccgct gataatatgg tcacaaagcc gtttcttcat 1504621 caaatgcctg agtatttaaa ggccattgat gtcattgtgg ccagagccgg tgcgacaacg 1504681 attgccgaaa ttactgctct cggaatccca agtgttctga tcccaagtcc atatgtgaca 1504741 gcgaatcacc aggaggtcaa tgcgaggtct cttggccagc atgatgcggc gattgtactg 1504801 aaagaaacag agctcagcgg ggagaagctg attgaagcgc tagaccggat tgtactgaat 1504861 gagcaaacgt taaaggaaat gagcgaacga acaaagtcac tcggtgttcc tgacgcggct 1504921 gcccgtttat acagcgtact cgaggaatta aaaaaatagt agaaaagcaa atggaatgcg 1504981 gaggtttacg atggagaaag tgatacagga attaaaagaa cgagaagtcg gcaaggttct 1505041 tgcaaatgaa ccgctcgcga atcatacaac gatgaaaatc ggcggacctg cggatgtatt 1505101 ggtcattcca agcagtgtgg atgctgttaa agacatcatg gacgtgatta aaaaatatga 1505161 tgtgaagtgg acagtcatcg gccgcggatc aaatcttctt gttttagatg aaggaattag 1505221 aggcgtagtg atcaagctgg gggcgggtct tgaccatttg gagcttgaag gggaacaagt 1505281 aacagtcgga ggcggttatt cggtggtccg ccttgctaca tcattgagca aaaaaggcct 1505341 gtccggtttg gaatttgctg ccggcattcc aggatcagtc ggcggagcgg tttatatgaa 1505401 tgccggcgct cacggttctg atatgagcga gatcctcgtc aaagcgcata ttttatttga 1505461 agacggaacg attgagtggc tgacaaatga gcagatggat ttcagctaca ggacatctgt 1505521 actgcaaaag aaacgcccgg gcgtttgcct tgaagctgtt ttgcagcttg agcagaagga 1505581 taaggaatca atcgttcagc aaatgcaaag caataaagac tatagaaaaa atacacagcc 1505641 gtattcaagc ccttgtgcgg gaagcatatt cagaaatccg cttccgaatc atgccgggaa 1505701 ccttgtagaa aaagcaggct tgaaaggata tcaaatcggc ggtgcaaaga tatcggagat 1505761 gcacggaaac ttcatcgtca atgcgggggg agcatcagca aaagatgtgc ttgatctcat 1505821 tgaccatgtg aaaaagacaa tccgtgaaaa atacgagatt gatatgcaca cagaggttga 1505881 aatcatcggc ggaaatcgct gattcaagtt ctgactgaag ctgttcatat gatatactgt 1505941 aagcaaacga caaacggcat catagtatgc cgtttgtttt ggaatagaca gacttttaac 1506001 agctgtttca tttgaatgag gtgaacaggc aatgaacccg ggtcaagacc gagaaaaaat 1506061 cgttaacatt gaagagcgga tccctaaaat taaagagcag aggaaacaaa aggcaaaccg 1506121 ccgtctcatt tcatttatta tgctcttttt tattatggtg ctgatcattg tgtacctgca 1506181 aacaccaatc agtaaagtat caacaatctc tgttacaggg aatgaaaatg tatcaaaaaa 1506241 ggaaattatc gacctttccg atattaacag cggagatact gagttttgga gtttggacaa 1506301 gcaaaaaaca gaaaagaaga ttcagcaaaa taaattagtg aaaaaagcgg agatcagcaa 1506361 atcgcttcct aataaaatca acattgcaat cgaagaatat aaagcgattg cttatttaga 1506421 aaaagacgat gtgtactatg aagtgcttga aaacggctca gttctgccaa acgaagtaac 1506481 gccggatgat gccggaccga ttttagtgaa ttggacaaac gcgaagaagc ggtctcaaat 1506541 ggccaagcag ctcgatgcgt tgtcaaattc gttaaaacag tcgatttcag aaatttatta 1506601 tacgcctgta aaaatggatg aaaaccgtat taagttgtac atgaacgacg gttatgttgt 1506661 tacggcatct attaaaacgt ttgcagaccg aatgaagacg tatccttcta tcatctcaca 1506721 gctaagcagc aataaaaaag gaatcattca tttagaagtt gccacctatt ttgaagagtt 1506781 tgggaaaaac gataaagctg ctaaaaagga agatgaaaat tgaggggcaa atcagcagtc 1506841 cttctttcct tgattatgct tatcgcaggt tttttgattt cattttcttt tcaaatgaca 1506901 aaagaaaaca acaaaagcgc ggctgagacg gaagagtgga aaaaagaata tgcgctgaga 1506961 gatgaactgc tgaaacaaga gaaagaaaat aagaagtttg aaaaagaatt atatcaaaag 1507021 caaaacaaag tccgccaggc ggaaaataag ctgaagaaag agaagtcgga atactataat 1507081 gtcctcgaag atacagaaaa atacaggatg tatattgggg aagtcggtgt gcagggagaa 1507141 ggcgttgagg tgacattgga agatgcgtca tacataccgg aaggggagaa tgtgaatagt 1507201 tacatcgttc acgaaagcca tatcttccaa gtagtaaacg aactgtatat ctcaggagcg 1507261 gcagctgtcg ccgttaatgg acagcgtttg acgcatgatt cgtatatcaa atgcaatggt 1507321 cctgtggtaa cggtagacgg ggtgcagcat cccgctccgt ttacggtatc cgctattgga 1507381 gatccagatg tcctgctgcc ctcgttaaat atcgctggag gcctaattga tcagctgtca 1507441 atggatcata tttctgtgtc ggcagaaaaa gagaaaaacg tacaaatgaa accgattctg 1507501 aaaacgaagg aatgactgaa aaagcgggtg aaatagattg aaaataaagc gttccttcat 1507561 aagcatcagt gttcttatgg tcatcttcgg cctgatgata tctgttcagt ttaattcgtt 1507621 aaagcacccc aaagtccggg atacaagaga tatgtgggat attagggaag agctgacatc 1507681 agagcagaag aagcaggaaa agctgctggc tgaaataaac aaatatgaca aattgctgaa 1507741 tagctattcg caaacgaaag aaatgacaaa agaaaccgcg ctaaataata ccttgcaatc 1507801 cttaaaaaaa acagccggca tgaccgatat aacaggtagc ggaattgtca ttacgatttc 1507861 cccgcttttt tctgaaagct taacaggaga gccgatcgaa aatccgcctc cggatttgct 1507921 gaaaaagctg ataaatgaac tcaactccta cggtgcagag catatctcga ttaatgagcg 1507981 aagagttgtg aatcatacag tcatcagaga tataaacggc actacaaaaa tagacggata 1508041 cgcccttgac gattatcctt taacagtaaa agtgcttgcc aaagatccgg acatgttaca 1508101 cagcagagtg aaggggtcag gccttgagga tctttttgca tctgaaaatt tagcattaaa 1508161 agccggtaaa tctgaaagca aactaacatt aaaagcatat gacagaccac tggacgtaca 1508221 acagctgaaa ctgcttaaag actgaaaagg aggagaattg tcatgtggct gcccgtgttg 1508281 ggactggtgc tcggaatagc gattggacta atgacaaact taacgatacc gagtgaatac 1508341 tcaaactatt tatcgcttgc ggtgcttgcc gcacttgata cattaatcgg cggaatcagg 1508401 gcgcatttac aaggtacata tgatgaaatg gtatttgttt ccggtttctt ttttaatatt 1508461 atattggcaa taagtttagc ttttctggga gtccatcttg gtgtagactt gtatttagca 1508521 ggtatattcg catttggagt cagattattt cagaatatag ccgttatcag aagaaatcta 1508581 ctaacaaagt ggactctttc taaaaaaaat aaaaaaaatg tgatataaaa gaggatatac 1508641 ataggatata acgaatattt tcaataaaca taaaatgtga aaagcacata aaaatattct 1508701 gttgttattt tttgttacac acttgtaaag ccacattcat tgtattgttg ttccgcaaat 1508761 aatagaatag aaatgatcga aatgtgagga ggtgccatag aatgaacaac aatgaacttt 1508821 acgtcagtct tgacatcggt acgtccaata caaaagtgat cgtcggagaa atgacagatg 1508881 attcccttaa tattatcggt gtgggaaatg taccgtctga agggttgaaa aaaggctcaa 1508941 tcgttgatat agatgagacc gttcattcta taagaaaagc gtttgaccaa gctgaaagaa 1509001 tggtaggttt tccgcttaga aaagctattg tcggcgttaa tggaaattat atcaatattc 1509061 aagatacaaa cggtgttgta gcagtttcca gtgaaaataa agaaattcag gttgaagatg 1509121 tacgccgtgt catggaggcg gcacaggttg tttccgtacc gcatgaacag ctgattgttg 1509181 acgtcattcc taaacagttt atcgtagatg gaagagatga aatcaccgac ccgaaaaaaa 1509241 tgctgggtgt gcgtttagaa gtagagggca ccttgatcac cggttcaaaa acaatcttac 1509301 ataacttact ccgctgcgtt gaaagagctg gtattgaaat aactgatatt tgccttcagc 1509361 cgctggcagc cggttctgct gcattatcaa aggacgagaa aaaccttggt gtggctctca 1509421 ttgatatagg gggagggtca acaaccattg ccgtattcca gaacggacat ctcacttcta 1509481 cccgtgtcat tcctctcgga ggcgaaaata tcaccaaaga tatctccatc ggattgagaa 1509541 cgtcaacaga agaagcagaa cgcgtgaaaa agcaacttgg acatgcctac tatgacgaag 1509601 cctcggaaga tgaaatattt gaggtaaccg ttataggcac caatcaaaaa caaacattta 1509661 cacagcaaga agcagcgaat atcattgaag cgagagtaga ggaaattctt gaaattgttt 1509721 cagaagagct tcgcagtatg ggaattaccg atctgccggg aggcttcgtg ctgacaggag 1509781 gacaagcagc tatgccgggt gtcatgtctt tggcacagga tgtgctgcaa aacaatgtca 1509841 gagtggcaag cccgaattat atcggtgtaa gagatcctca atatatgacg ggagtgggcc 1509901 tgatccaatt cgcctgccgg aatgcaagaa tccaaggcag aaaaataggc tttaagatgc 1509961 ctgaagaagc gatacaggaa atcgcagtct catcatctga ggaacaagag cagcatcatc 1510021 accaaaatga ggtgcagcag cggccaaaag gaaaacaaaa aacacaagcc gaacataata 1510081 aacagagcaa aatgaaaaaa ctattaagca tgttttggga atagatagat agtcattcgg 1510141 cagattagga ggatttagca tgttggagtt cgaaacaaac atagacggct tagcatcaat 1510201 taaagtaatc ggagtaggag gcggcggtaa caacgccgtt aaccgaatga ttgaaaatga 1510261 agtgcaagga gtagagtata tcgcggtaaa cacggacgct caagctctta acctgtcaaa 1510321 agcagaagtg aaaatgcaaa tcggcgcaaa gctgactaga ggattgggag caggtgcgaa 1510381 tccggaagtc gggaaaaaag ccgctgaaga aagcaaagag cagattgaag aagcacttaa 1510441 aggtgctgac atggtattcg tgacagctgg tatgggcggc ggaacaggaa caggtgccgc 1510501 accggttatc gcacaaatcg cgaaagactt aggcgcatta acagtcggcg ttgtgacaag 1510561 accgtttacc ttcgaaggac gcaaaagaca gcttcaggct gcaggcggaa tctcggcaat 1510621 gaaagaagcg gtggatacac tgatcgtgat cccgaacgac cgtatccttg aaattgttga 1510681 taaaaacaca ccgatgcttg aagcattccg cgaagcggat aacgtacttc gccaaggggt 1510741 tcaaggtatt tctgacttga ttgctacacc tggtcttatc aaccttgact ttgctgatgt 1510801 gaaaacaatc atgtcaaaca aaggatctgc tttgatgggt atcggtattg ctactgggga 1510861 aaatcgcgcg gcagaggcag caaaaaaagc aatttccagc ccgcttcttg aagcggccat 1510921 tgacggtgcg caaggcgtcc tcatgaacat cactggagga acaaacctca gcctatatga 1510981 ggttcaggaa gcagcagaca ttgtcgcttc ggcgtctgat caagacgtaa acatgatttt 1511041 cggttctgtt attaatgaaa atctaaaaga tgagattgtg gtgacagtga ttgcaaccgg 1511101 ctttatcgaa caagagaagg acgtgacgaa gcctcagcgt ccaagcttaa atcaaagcat 1511161 caaaacacac aatcaaagtg ttccgaagcg tgagccaaaa cgtgaggaac ctcagcagca 1511221 gaacacagta agccgtcata cttcacagcc ggctgatgat acgcttgaca tcccgacatt 1511281 cttaagaaac cgtaataaac gcggctaatg taaaggacaa aatcgttttc gattttgtcc 1511341 ttttttgttt ttctcttcac actttccttc ttataaagtc tttttcccta ttgcttcctt 1511401 cgcttagtaa caaaacagat aattagaccc atttattttt gtgacatttt tatcattttc 1511461 atatatatgg aaattgaatg acatgaaacg acaatatctg taattcagat tgtctacagt 1511521 taatatacag cgatgttctg acaaaccatt cattattaaa aggagggacg acactttttt 1511581 taaaaagcat gttgaaaaag ggggatgaaa atgaggaaaa aaacgaaaaa cagactcatc 1511641 agctctgttt taagtacagt tgtcatcagt tcactgctgt ttccgggagc agccggggca 1511701 agcagtaaag tcacctcacc ttctgttaaa aaggagcttc aatctgcgga atccattcaa 1511761 aacaagattt cgagttcatt aaagaaaagc tttaaaaaga aagaaaaaac gacttttctg 1511821 attaaattta aagatctggc taacccagaa aaagcggcaa aagcggctgt taaaaaagcg 1511881 aaatcgaaga agctgtctgc cgctaagacg gaatatcaaa agcgttctgc tgttgtgtca 1511941 tctttaaaag tcacagccga tgaatcccag caagatgtcc taaaatactt gaacacccag 1512001 aaagataaag gaaatgcaga ccaaattcat tcttattatg tggtgaacgg gattgctgtt 1512061 catgcctcaa aagaggttat ggaaaaagtg gtgcagtttc ccgaagtgga aaaggtgctt 1512121 cctaatgaga aacggcagct ttttaagtca tcctccccat ttaatatgaa aaaagcacag 1512181 aaagctatta aagcaactga cggtgtggaa tggaatgtag accaaatcga tgccccaaaa 1512241 gcttgggcac ttggatatga tggaactggc acggttgttg cgtccattga taccggggtg 1512301 gaatggaatc atccggcatt aaaagagaaa tatcgcggat ataatccgga aaatcctaat 1512361 gagcctgaaa atgaaatgaa ctggtatgat gccgtagcag gcgaggcaag cccttatgat 1512421 gatttggctc atggaaccca cgtgacaggc acgatggtgg gctctgaacc tgatggaaca 1512481 aatcaaatcg gtgtagcacc tggcgcaaaa tggattgctg ttaaagcgtt ctctgaagat 1512541 ggcggcactg atgctgacat tttggaagct ggtgaatggg ttttagcacc aaaggacgcg 1512601 gaaggaaatc cccacccgga aatggctcct gatgttgtca ataactcatg gggagggggc 1512661 tctggacttg atgaatggta cagagacatg gtcaatgcct ggcgtgcggc cgatattttc 1512721 cctgagtttt cagcggggaa tacggatctc tttattcccg gcgggcctgg ttctatcgca 1512781 aatccggcaa actatccaga atcgtttgca actggagcga ctgatatcaa taaaaagctc 1512841 gctgactttt ctcttcaagg gccatctcca tatgatgaaa taaagccgga aatatctgca 1512901 ccgggcgtta atattcgttc atccgttccc ggtcagacat atgaggatgg ttgggacggc 1512961 acatcaatgg cagggccgca tgtatccgct gttgctgcac tgctgaaaca ggcgaatgcc 1513021 tcactttctg ttgatgagat ggaggatata ttaaccagca cggctgaacc gctcacggat 1513081 tcaacatttc ctgattcacc gaataacgga tatggccatg gtctggtgaa tgcttttgat 1513141 gctgtatccg ctgttacaga tggattaggg aaagcggaag gacaagtttc tgtagagggg 1513201 gatgaccaag agcctcctgt ctatcagcat gagaaagtaa ctgaagctta tgaaggtggc 1513261 agcctaccac tgactttgac agctgaagac aatgtgagtg tgacatctgt aaagctgtcc 1513321 tacaagcttg atcaaggtga atggacagaa ataacggcta aacgaatcag cggtgatcat 1513381 ctaaaaggaa cgtatcaggc agagatccca gatataaaag gaactaaact aagctataag 1513441 tggatgattc acgattttgg cggtcatgtc gtttcgtctg acgtatacga tgtaacagtg 1513501 aaaccaagca tcacggcggg atataagcag gactttgaaa ctgcacccgg cggctgggtt 1513561 gcgagcggaa caaataataa ctgggaatgg ggagttccgt caactggccc aaatacagca 1513621 gcatccggag aaaaagtata tggaacgaat ttgacaggaa attatgccaa ctcagcaaac 1513681 atgaaccttg ttatgcctcc tattaaagca cctgattcag gaagtctgtt ccttcaattt 1513741 aaaagctggc acaatttaga ggatgatttt gattacggct acgtttttgt tcttccggaa 1513801 ggtgaaaaga attgggagca ggctggtgtc tataacggaa agacatcaag ctggacggac 1513861 gaagaaattg atttatcggc ttataaaggc caaaacattc aagtgatgtt taaccttcaa 1513921 tctgatgaaa gcattgcaaa agagggctgg tatattgatg atgtagtgct ttctgacaaa 1513981 tcagccggaa aaacagtcaa aaagaataag ctgggcgtcg aaaagccgtc tggaaagcaa 1514041 aagaaaaagc cagtaaatcc gaaaaaggct aagccatctg caaacacagc ggtaaaacat 1514101 cagaacaagg ctatacagcc tcaagttttg ccgctcaagg cacaagtcag tgtagtggaa 1514161 acaggaaaat caacatattc agatcaatcc acagggcagt acacgctgaa gcacaaagcg 1514221 ggagactata cgcttatggc agaagcatat ggttatcagt cgaaaacaca aaaagtatct 1514281 ttaaagacgg atcagacgac acaagctaat tttacgttag aagagatgaa gaagggcaca 1514341 ttaaaaggca cggtcatcaa taaaacgaca ggagagccgg taacaggcgc ttccgtttat 1514401 gttgtagagg atgctgcggt ggaaccggct atgacaaacg acaaaggtga atatatgctg 1514461 gaggcctatg aaggcgctta tacgattaaa gtcgctgcac cgggttatta cagtgatgaa 1514521 ttttccgttg agttaaaagg tgatgttaca aaagaaactg cattgaagcc tttcgtcggt 1514581 tatccgggtg aaattgcata tgatgacgga acagcggaga atgccaattc ctattttgct 1514641 gccggtaacg gatgggcggt aaaaatgacg ctcgctgacg gcaaggacaa aggcatgctt 1514701 acaggagggc tgttcagatt ctgggataca gagttccctg atccgggcgg cacagagttt 1514761 aaggttgagg tatacgatgc cacaggaaaa gacggagcac cgggcaagaa aattgcaggg 1514821 ccatttaacg cggaagctct tcgcaatggc gagtggacta aggtagatct cagttcaaaa 1514881 gggattatgg tcgataaaga tttttatctc gtatatatcc agtcgaaacc tgatccgtat 1514941 tcacctggat tggcaatgga tgaaaccggc cagaattccg gccgcaactg gcagtatata 1515001 gatggaaagt ggcagccagg tgacaaagcg gatggcaact atatgattcg cgcattagtt 1515061 gattatgaag ctgctgtacc tgagattact tcaccgacag acaaatcata cacaaataag 1515121 gatagcgtca ctgtaaaagg aaacgcttct cctggcacaa cggtacacat ttataatgga 1515181 gagaaagaag caggagaaac gaaagctgct gcggatggca cgttccatgc aggcatcata 1515241 ctcaacaagg gtgaaaatga gctgacggca actgcatcaa ctgacaacgg aacaacagat 1515301 gcctccagcc caatcacggt cacgcttgat caagaaaagc ctgaattaac actggacaat 1515361 ccaaaggatg gcgggaaaac aaataaagaa acgctgactg tcaaaggggc tgtatccgat 1515421 gacaatctga aagacgtcaa ggtgaatggc aaaaaagcaa cagtagctga tggttcatac 1515481 tcagcccgta ttcttttgga aaatggaaga aatgaaatca aggtaattgc tacagacttg 1515541 gcaggcaaca aaacgacgaa aaagacagtc attgatgtga actttgacaa gcctgtcatt 1515601 tccggcttaa ttccgggaga ggataaaaac ttaaaagccg gtgaatctgt gaaaatcgct 1515661 ttctcaagcg ctgaggattt agatgcaacg tttaccattc gtatgccgct gaccaatgca 1515721 agagcgagtg tgcaaaatgc caccgaactc ccgttaagag aaatctctcc ggggagatat 1515781 gaaggctatt ggactgccac ttcttctatt aaagcaaaag gagcaaaagt agaagtgatc 1515841 gtccgagatg attatggaaa tgaaacaaga aaaactgcga atggaaaact taatatgaac 1515901 acagaaaatt aagtggaaaa aaagctgccg tcattggcag ctttttttat atcctctcat 1515961 tatacttcct cgacaaatta agcagatttc cctgaaaaat tgtattttcc tctcaacatt 1516021 aattgacaga ctttcccaca gagcttgctt tatacttatg aagcaagaag gggaacagcg 1516081 tgaggcaaga aagaaaggag tcagatgtga aaatctattt agatgtcatt tggctgttaa 1516141 acttttgttt tgatgcactt ttgcttttgc tcacggcatt tattttaaaa cggcatgtaa 1516201 aaaaaagaag actggtaggc ggagcgttca tcggttccag tattgtcctt ttgatgttta 1516261 ctcctttttc gccgattgtt gaacatccgg ctgggaagct agctttttca gttgtgattg 1516321 tggtggtgac atttggcttt aaaagatttc ggtttttctt tcaaaatttg ttttcctttt 1516381 attttgccac ttttttaatg gggggaggaa ttatcggagc ccattctttg ctgcagtcaa 1516441 attctattgt tcaaaacggt gtcatgatta ccaatcaaac agggtttgga gacccgatca 1516501 gctggttgtt tattgttggt ggctttccag cattatggtt tttttctaaa agaagaattg 1516561 aagatattga aacaaaaaac attcaatatg aggaacgagt cagcgtgcag gcagatttgg 1516621 gcagccaaac acttcatgtc agaggcctga ttgattccgg taaccagctg tacgatcctc 1516681 ttacaaaaac accggtaatg atcatttaca ttgataaact ggagccgatt ttcggaacag 1516741 ccgaaacgat gatcattcga aacacagacc cattggaagc catcgaacag ctcgatgatt 1516801 cctttcgctt tttagataaa atgaggttga ttccatacag gggagttggt cagcaaaatc 1516861 aatttttatt atgcgttaaa ccggatcacg taacgattat gacaaaagaa gaaatgattt 1516921 ctgcagataa atgtttaatc ggtatcagca caacaaagct gtcggcagat ggagagtttg 1516981 acgcgattat tcatccgaaa atgctttcgg gcaaggctgt caaacacgtt tcataatgtt 1517041 cgcaaatgtc cgttacttat catactcaaa cggcgtgaca tttagaaggg agaggaagat 1517101 gaaaaaactg aaattacggt tgacgcacct ctggtataag ctgctgatga aacttgggct 1517161 gaaaagtgat gaagtctatt acataggcgg gagtgaagcc ctgccgcctc cattatctaa 1517221 agatgaggag caggttttgt taatgaagct cccaaacggc gatcaggcgg cgcgcgccat 1517281 tctaattgaa cgcaatttgc gtctggtcgt atatatcgcc cgtaaatttg aaaatacggg 1517341 aattaatata gaggatttaa tcagcatcgg taccatcggt ctaatcaaag ctgttaatac 1517401 atttaatcca gaaaagaaaa tcaagcttgc tacctatgcc tcccggtgta tagaaaatga 1517461 aatcctgatg tatttaagaa gaaataacaa aatccgttca gaggtttcct ttgatgaacc 1517521 gcttaatatt gattgggacg gcaatgagct tttgctttct gatgtgctcg gcactgacga 1517581 tgacatcatc actaaagaca tagaagctaa cgtcgataaa aagcttttga aaaaagcgct 1517641 tgaacagctt aatgagagag aaaagcaaat catggagctg cggtttgggc ttgtcggtga 1517701 agaagaaaaa acccaaaagg atgtagcgga tatgatgggg atttctcagt cttatatttc 1517761 gcggcttgag aaaagaatta taaaaaggtt gagaaaagag ttcaacaaaa tggtgtaaaa 1517821 aattttatgg ttagaacccc ttgattttac agggatttcc tgatttcgac agtttttcgg 1517881 tctgagtgca gtgcatattt ttcccaccca aggagatact taacgttgta cagcagctcc 1517941 tgtagggagg gaaaaaagtg tcgagaaata aagtcgaaat ctgcggggtg gatacctcca 1518001 aattaccagt actcaagaat gaagagatga gaaagctgtt taggcagctg caggatgaag 1518061 gcgatgattc agcaagagaa aagcttgtaa acgggaactt gcgtcttgtc ttaagtgtca 1518121 ttcaacgatt taataacaga ggggagtatg ttgatgactt atttcaagtc ggctgcatcg 1518181 gactaatgaa atccattgat aattttgacc taagccacaa tgttaagttt tcaacatacg 1518241 ctgtacctat gattatcgga gagatccgca ggtatttacg tgataataac ccgatccgtg 1518301 tctcaagatc actccgggac atcgcttaca aggcgcttca ggtaagagag cggttaatca 1518361 gtgagacaag caaggagccg actgcagaag acatcgcaaa agttcttgaa gtaccgcatg 1518421 aggaaattgt atttgcgctt gatgccattc aggatccggt ttctctattt gaaccgatct 1518481 ataacgacgg cggagacccg atctatgtga tggaccaaat cagtgatgag cgtaatacag 1518541 attcacaatg gattgaagag ctggctttaa aagagggcat gagaaggctg aacgataggg 1518601 aaaaaatgat tttgagaaag cgattcttcc aagggaaaac ccaaatggaa gtcgccgagg 1518661 aaatcggaat ttctcaagcg caggtgtcca gacttgaaaa agcggctatc aaacaaatga 1518721 ataaaaatat tcatcaataa tgaaaagcct ttaaaacgat gttgttttaa aggcttttct 1518781 attgattatg gatggtttac gttttggaaa aagtaaggta tcctagttcg tacaaagttt 1518841 tatgaaaatt aaaacaatta taaaaggcaa taaagaggag gaccacgatg attttgcagc 1518901 ttgacaatgt ctcactaaaa cggaatggga aatggatact gaaagatatt cattggaagg 1518961 tggaagaaaa ggaaaattgg gtgctttacg gcctaaatgg cgccgggaag acagcgctgt 1519021 taaatatgct ttgctcatat tattttccaa catcaggcga gatgcaggtg ctcggccatg 1519081 aatttggcaa aacagagctt ggggaaaagc tcagacgtaa aattggcctc gtctcagcag 1519141 ctcttcagca aaaattgtat ccggcagatt cagcttttga aattgctttg agcggagctt 1519201 acgcttcgat tgggttatat gaaacgccaa gtaaggaaac cagggaaaaa gcgataggtt 1519261 tgttagagga cttgggagca attgaatatg ccgatcgccg ctatgaaacc ctttctcaag 1519321 gggaaaaaca aagagcattg attgctagag cactaatggc cgatccggag ctgctgatac 1519381 tggatgaacc agtcacagga ctggatttta ttgcccggga aaagctgtta gatacgatta 1519441 catacattgc aaacaaagaa aatgcaccat ctatccttta tgtgactcat catgctgaag 1519501 aaattttgcc tgtctttgat aaagcccttt tattaaaaca gggagaggtt tttggatccg 1519561 gagaaataaa ggaaatgctt actgatcaaa tactttccgc tttttttgat acgccaatcc 1519621 atgtattatg gaatcaggat cggccgtttt taacaagagc tgagccgata acgaatgcct 1519681 gacaaatata tatagattca tcctaggggt gctttgcgaa gctgagagag actttgtctc 1519741 aacccttttg acctgatctg gatcatgcca gcggagggaa gcggtgaaaa gcggagtaca 1519801 tcggactccg tttgttttta ttaagccgtt tcatcacatt tgaaacggct tttttgattt 1519861 taaagaatag gagcggattt acattggatc aacaaatata ctctttgcaa aaaaaagtgg 1519921 aagaacataa ggaggagctt attcagcttg cgaaaacgct gatttcttat caaacacctg 1519981 ctccgcctgc aagaaataca gagggcattc agtcttggat tgcgggatat ttaaatgaat 1520041 tgggattctc gatcgacaaa tgggatgtgt accctggaga tcccaatgtt gtagggaagc 1520101 taaaaggaac agattcagca gattattata gcctgattat caatggccat gtagatgtgg 1520161 cagaggtaaa agaggatgaa gaatggaagc acgatccgtt tcatcccatt gaaaaaaacg 1520221 gtctcttaat cgggcgaggc gcttccgata tgaagggcgg aatggcttgt gtgctgtttg 1520281 ctgtcaaatt aattcgtgaa gcaagcattg aacttccagg tgatctgatt ctgcaatcgg 1520341 ttattgggga ggaagttgga gaggccggca cacttgaatg ctgcaagagg ggctaccacg 1520401 ctgattttgc aattgtcgcg gatacgagcg atatgcatat tcaaggccaa ggcggtgtca 1520461 ttacaggctg gatcgaaatc aaaagcagtc aaacatttca tgatggaacg agacggaata 1520521 tgattcatgc aggcggagga acattcggag caagcgcaat tgaaaaaatg gcaaaaatca 1520581 ttgcggggct cggtgaactt gagcgccact ggtctattat gaaaagttat cccggtttta 1520641 aaccaggcac aaatacgatt aacccggcag ttatagaagg cggcagacat gcggctttta 1520701 tagcggacga atgccggctg tggatcacag tccattttta tccgaatgaa acccatgacc 1520761 aagtggcagc ggaaatagaa gattacgtca atcggctgag tgacagtgat atttggctta 1520821 gggaaaaccg ccctgtattc aagtggggag gctcatctat gatagaagac aggggagaaa 1520881 tttttccggc attggaagtt gaccctggcc acccaggcgt cttagcgcta actgcctctc 1520941 atcagaaagt gaaacgggag tgtccaatta ttgacgtttc tcaatcagtt acagatggcg 1521001 gatggctgta tgatgccggt attccatgcg taatatacgg tcctggagat ctgcacaatg 1521061 cacactctgt gaacgagaag gtatcgattg agcagctagt agagtataca aaaattatac 1521121 tcgattttat catcagctgg tgcagccgga aaaaagaaca atgacatgaa aatttcttct 1521181 tgctgacaag gttcagcctg cccgttcata tacttgaaca aaaggacgga aaaaggacgt 1521241 gatggaatga tcagcatttc agaatttcag gtaaaggatg tcgtcaatgt ctcaaacgga 1521301 aaaaagctgg ggagtattgg tgatattgat atcaatgtga ccactggaaa aattcaggcg 1521361 atcatactcg gaggaaatgg gaaagttctc ggattttttg gaaaagaaga ggaattggtc 1521421 attccatggc gaaatatagt aaaaatcggg gaagatgtaa tcttagtccg attaagtgaa 1521481 ccacatgcat aaacctgctt gtctgccgca gattggcaaa tgccggaagt ctcgattctt 1521541 ccggcacatt tcatttagaa atatgcaaat cggcgctcaa cgaatgcagt aagatgtggt 1521601 aaaataagtg ggaaattccg cttttttaaa tgtttgtcga aaggttggat catcatgaat 1521661 acatatcacc cattcagtct taccacaccc tcgacactca tgatacaaga ctgggctcaa 1521721 acgaatcaaa acaacaaaga ggtcattgcc ggatttacga caaaaaacgg cggtgtcagc 1521781 caaaagcctt ttgaatcgtt aaatacagga ttgcacgttc atgacaaaga tgcagatgta 1521841 gttaaaaatc gtgaatatat tgccgatatg tttaatactg atttgcagtc ttgggtattc 1521901 gctgatcaga cacatgataa tcgcgttcag aaagtgacgc agagggatag gggaaaaggc 1521961 gcccgtgagt atcacacggc tctaaaagca acggacggga tctatacaaa tgaaaaaaat 1522021 gtatttttag cattatgctt tgctgattgt gtgcctcttt tcttttatga tccggttaag 1522081 tcgcttgtcg gagtcgccca tgccgggtgg aaaggcaccg tcaaacagat tggcagagaa 1522141 atggtgaagc aatggactga gaaggaaggt tcaaatccct cagatattta cgctgttatt 1522201 ggcccgtcta tcagcggagc atgctatacg gtagacgacc gcgtcatgga tgctgtccgc 1522261 gcattgccgg tttcagcaga ccttgccgcc aatcagacgg caaaggcaca atatcagctt 1522321 gatctgaaag agctgaaccg tcttatactg atggacagcg gtttggcaag tgaacaaatt 1522381 tctgtcagcg gtttatgcac ggaaagcgag ccgtctcttt tctattctca tcgccgcgat 1522441 caggggaaaa ctggacggat gatgtccttt atcggaatga aggaggcata aaagatcttg 1522501 cgtgttgttg ataatttacg acatataaac gaacgaataa acgaagcatg taacagatcg 1522561 ggccgcagct ccgatgaagt tacggttatt gcagtcacaa aatatgtatc acctgaaaga 1522621 gcacaggagg cagtagatgc tggcatcacc tgcctcggag agaatcggga tgcggaactg 1522681 ctccgcaaac aggaattgat gaaagggaat ccggaatggc attttatcgg cagtctgcaa 1522741 tcaagaaaag caaaatctgt cgtcaattcg gtttcctata tccattccct agaccggctc 1522801 tcattagcga aagaaattga aaaacgggct gaaggtactg tacgatgctt tgtgcaggtc 1522861 aatacctctc ttgagccttc taaacatggc atgaaaaaag aagaagtcat tccattcata 1522921 caggagcttt ccggtttcga acatatcctt gttgccgggc tgatgacaat ggctccgctg 1522981 actgatgatc aagatcagat cagaagctgt ttcaggtcgc tgagagaact ccgtgaccag 1523041 gttcagaagc tgaaccagcc gaacgctccg tgtactgaac tgtcgatggg catgtcaaat 1523101 gattttgaaa ttgcaattga agaaggagct acttatatta gaatcggctc atcgttagtc 1523161 ggaaatgaaa cagggggtgt acagcaatga gtatgaaaaa taaactgaaa aactttttct 1523221 caatggaaga tgaagaatac gaatatgaat atattgagac agagcgggaa tctcatgagg 1523281 agcatgagca aaaagaaaag ccggcttaca acgggaataa acctgcgggc aaacagaatg 1523341 tagtgagctt gcaaagtgtt cagaaatcct ctaaagtggt gttgagtgag ccgcgcgttt 1523401 atgcggaggc gcaggaaata gccgaccatt tgaagaaccg gcgggcagtt gtcgtcaatc 1523461 ttcagcggat acagcatgac caggcgaagc ggattgttga ctttttaagc ggaaccgttt 1523521 atgccattgg cggcgatatt caaagaatcg gctcagatat tttcctctgc acgcctgaca 1523581 acgtagatgt atcaggcaca atttctgagc tcatatctga agacgaacat cagaggtggt 1523641 aaagcgagat gatcctttat caagtttttt cggttttaag cttattaatc acaatatact 1523701 catttgccct gatcatatat atttttatgt catgggtgcc gagtacgagg gaaacagcag 1523761 tcgggcgttt tttggcttcg atttgtgaac catatctcga accattcaga aaaatcatcc 1523821 ctccgattgc aatgctggat atttcaccaa tcgtagcaat acttgtgctt cggtttgcga 1523881 caaccggctt gtggggactt tatcgcatga ttgcgtttta atgtgacagt ttgatagggg 1523941 cttggcagca gccaagcctc tttacataga agggaaagac gatgagcgat atatatcagc 1524001 acttcagaaa agacgagcgg gcctttattg atcaagcgct cgaatggaaa agaattgtcc 1524061 aggagcagta ccggatgaag ctgaccgact ttttagatcc ccgagagcag gtcatcctct 1524121 ctgctgttac gggacaggca gatgtcgggc ttgccttttc cggcggctat gacagagcgg 1524181 agcggaaacg ggcgattctg tttccagagt acattactcc ggaagaatca gattttgaac 1524241 tgcaggcgtt taacgtccgt tatgctgaca agtttgtctc agtagatcat cgttctctgc 1524301 ttggtgcatt aatgggcata ggattaaagc ggcaaaaatt cggtgacatc gtgttttctg 1524361 agacagcagt gcaattgatt gtctcagccg ataccgctga ttttgtggct gcacagctga 1524421 cccaagcagg caaagcggcg gtcagcctag agaaaatcga cttgtcagac cttaacattc 1524481 cagcagttga tgtcgaaata agagatgaca cggtttcttc tttaaggctt gacgccgtct 1524541 gcgcctctat gagcaggcaa tcccgccaga aatcacagac gcttgtgaaa aacggccttg 1524601 tgaaagtgaa ctggaaggtg gttgaagatc cttcatacat agtcgcggaa ggggacatgc 1524661 tgtctatcag aggttttggc cggtgcagct taacaaaaat cgaaggaaaa accaaaaaag 1524721 acaaatggag agttacgttt gaacgacaaa aatagtcggt ttttcagttt ttttctccat 1524781 ctgtgcgaaa tttgttttat aatgtgaact agataaccgt actgaaatgt aaaaatggag 1524841 gtggcatcat gccattaacg ccaaatgata ttcacaacaa gacgtttaca aaaagttttc 1524901 gcggatatga tgaagatgaa gtaaatgaat tcctagccca agtcagaaaa gattacgaaa 1524961 ttgttctccg caagaaaact gagcttgaag cgaaagtcaa tgagcttgat gaaagaatcg 1525021 gacactttgc caatattgag gagacattga ataaatcaat tttagttgct caagaagcgg 1525081 ctgaagacgt aaaacgcaat tctcaaaaag aagcaaagct gatcgttcgg gaagcggaga 1525141 aaaacgctga tcgcattatc aacgaatcgt tatcaaaatc aagaaaaatt gcaatggaaa 1525201 ttgaagagct gaaaaaacag tctaaagtgt tcagaacacg tttccaaatg ctgattgaag 1525261 ctcagcttga tcttctgaaa aatgacgatt gggatcatct ccttgagtat gaagtcgacg 1525321 ctgtatttga ggaaaaggaa taaattctct gattatcttg acattttctt agcttgtcga 1525381 atataatacg ttcataaatt cagatgaaaa aacggttgaa agggacagtc atgtttcctt 1525441 caggccttca tagcgacccg gagatggtga gagtccggga tggccggaat catgtagatc 1525501 agccctttag tttccttgct gaactcacag taggttagga cgttcatcac gttacgatgc 1525561 tcaagaggaa aaagtgtatg cttgcttttt ctaaaagggt ggtaccgcga gataagcttt 1525621 ctcgtccctt atgggatgag agggcttttt ttattttctg aaaaaatgca gtggaggaat 1525681 gaaaatggat tttaaagaca cgctcttaat gccgaaaaca gatttcccga tgcgtggaaa 1525741 tttgccaaac cgtgagcctg acattcaaaa aaaatgggag gaagaagata tctaccgtct 1525801 tgttcaggaa cggacgaaag accgcccgaa atttgtttta catgacggac ctccgtatgc 1525861 aaacggcgac atccatatgg gccatgcact taacaagatt ttgaaagact tcattgtccg 1525921 ctataaatca atgagcggct acaacgcacc gtatgtgccg ggctgggata cacacggatt 1525981 gccaattgaa acagctctga caaaaaacaa aaaggtcaac cgcaaagaaa tgtcagtagc 1526041 ggaattccgc aaactatgcg aagagtacgc ttggaagcaa atcgagggac agcgtgagca 1526101 attcaaacgt cttggtgtcc gcggtgactg ggaaaaccca tatgtgacat taaaaccgga 1526161 atacgaagcg cagcaaatcc gcgtatttgg tgaaatggca aaacgaggct acatttacaa 1526221 aggccttaaa ccggttaact ggtcaccttc aagtgagtct gctctggctg aagccgagat 1526281 cgaatatcaa gataaacgtt cagcatctat ttacgtcgct tttggtgtaa aagacggaaa 1526341 aggcgttctt gaaaacggcg agcgcatcat catttggaca acaacgccgt ggacaattcc 1526401 ggcgaacctc ggaatctcag tgcaccctga tcttgagtac agcgtgattg cagtaggtga 1526461 agaccgcttt gttgtagcaa gtgccttagt cgaaaatgtt gcatcggcat gcggatttga 1526521 tcagtatgaa gtgacaagaa cggtcaaagg gaaagacctt gagaacatta tcgctgaaca 1526581 cccgctatat ggcagagact ctctcgttat gcttggtgaa cacgtaacaa ctgatgccgg 1526641 aacaggctgt gttcatacag cgcctggaca tggggaagat gactttatca tcggccaaaa 1526701 atacggttta gatgtgcttt gcccggtcga tgaaaaaggt gtaatgacaa gcgaagctcc 1526761 tggctttgaa ggcatgttct atgatgatgc aaacaaagcg atcacacagc agcttgatga 1526821 aaaaggcgca cttgtgaagc ttgaattcat tactcattct tatccgcatg attggagaac 1526881 aaaaaaacca accattttca gagcaacagc gcaatggttt gcgtctatta aagatttcag 1526941 atcagacctg ctggatgcca ttaaagaaac caaatgggtt cctgaatggg gcgagcagcg 1527001 tttgcacaac atggttcggg accgcggaga ctggtgtatt tccagacagc gtgcgtgggg 1527061 tgtgccgatt ccggtatttt acgctgaaaa cggagaaccg gttattacag atgaaaccat 1527121 tgaacatgtt tctgaattgt tcagacagca tggatcaaac atttggtttg aaaaagaagc 1527181 aaaggatctt cttccggaag gctttacgca tcctggcagc ccgaacggca catttacaaa 1527241 agaacaggat atcatggatg tttggtttga ttcaggctct tcacatcaag cagtgcttga 1527301 agaacgtgat gacctcgttc gcccggctga tctataccta gagggatctg accaatatcg 1527361 cggctggttt aactcttctc tttctacagc agtagccgta acagggaaag cgccgtataa 1527421 aggtgtgctc agccatgggt tcgcactgga tggagaagga cgtaagatga gtaaatcaat 1527481 cggtaacgtt gttgttccgg ctaaagtcat gaaacagctt ggtgccgaca tcttaagatt 1527541 atgggtatct tcagtggatt atcaggcgga cgttcgcgtg tctgacgcca ttctgaagca 1527601 ggttgcggaa gtatatcgta aaatccgcaa cacgttccgt ttccttcacg gcaacctttt 1527661 cgattttgat ccaaaaacaa atgcggtggc tgtcgaagat cttcgcgaag tggatcagta 1527721 tatgctgatt aagctgaaca agctgattga taaagtgaaa aaagcgtatg atgagtacga 1527781 atttgcggtt gtgtatcaca gcattcataa tttctgcaca atcgaattga gctcattcta 1527841 ccttgatttt gcaaaagata ttgtctacat cgagcatgcg gatcatccgg atagacgcag 1527901 catgcagaca gtattctacg aaacgcttct tgcattagtg aagctttcag cgcctatcct 1527961 tccacatacg gcagacgaat tgtggtctca tttaacattt gttgaagagc agagcgttca 1528021 gttgaccgat atgccggaaa caatcacggt tccaaacagt gaagcgactg aagaaaaatt 1528081 tgaccgcttt atggctcttc gtgatgacgt gttaaaagca ttagaaactg cgcgaaatga 1528141 aaaaattatc ggtaaatctt tggaagcaaa cctgaaattg tatccaaaca aagaaaacaa 1528201 ggagctcttg gcttccataa aagaaaacct ttctcagctg tttattgtgt ctgaactgac 1528261 aatcagcgaa gaaaatgaag cgccgaacga tgcgcaaagc tttgcgacgg gtaaaatcgc 1528321 tgtcgagaaa gcggaaggcg aaatgtgtga gagatctcgt gtgatttcaa aagatgtagg 1528381 ggcaaatccg aaatatccta cactttcatt acgcaacgct gaaatcgttg aaaaatacta 1528441 tcaaaaataa tgcaaaagag cccggcgtaa aagccgggct ttttttgtgc caagagtgac 1528501 atcctttaga acgaaaggaa aaatcttatg ggctttagat catcattcac aggcaacaat 1528561 aaagatacta cgttaagagc aggagttgtg aagaatgaat gatcaactga ccgcaattta 1528621 tacggaactt cttctgatga aagaagaatt acagtcgaga ttatttgagt attcttgctt 1528681 tcaggtttct acaagcccgc aagcagcaat caatcaaaaa caaaaagcaa ctctgatcta 1528741 tcatattaaa gaagaacttc aagacgttct ccttgcattg tccaaaatcg aaaacggcac 1528801 attcggatac tgtgaagaaa ctggggcccc cattcctctt gcaaagctgg cagtgctgcc 1528861 gacggcccga acagcaaacg attttcttta ttctgtccaa tttgagaaaa aaacgcttcc 1528921 gatatggaaa tcaacggata tcgaatatgg tcaggcactg tatgaataac agtgtctgtc 1528981 cggttaatat gcctgatatt tctttactcc agtgcttttt attgataaaa tgcataatgg 1529041 attaaagtaa ccgtaaactg gaggaacgtt tgtgctgtat tatatgattg cactacttat 1529101 tattgcagcc gatcaattga caaaatggct agttgttaag aacatggaac ttggccaaag 1529161 cattccgatc attgatcagg tattctatat cacctcccat cgcaatacgg gtgctgcatg 1529221 ggggatatta gcgggtcaaa tgtggttttt ctacctcata acaaccgctg ttattattgg 1529281 tattgtttat tacatacagc gttatacaaa gggacaaagg cttcttggcg ttgccctcgg 1529341 acttatgctt ggcggtgcca tcggcaactt tatcgatcgg gctgtcagac aggaagttgt 1529401 ggattttatc catgttatta ttgtcaatta caattacccg atatttaaca tcgcggactc 1529461 ttcactatgt gtcggcgtaa tgcttttatt tatacaaatg ctgttggaca gcgggaaaaa 1529521 gaaaaaggag caatagcatg aatcaaattg atataaccgc ttcagaagaa caaaaaagtg 1529581 agcggattga taaatttttg gcatcgactg agaatgattg gtcaagaacc caggttcagc 1529641 aatgggtaaa agacggacag gttgtcgtga acggaagcgc ggtgaaagcg aattataaaa 1529701 ttcagccggg tgatcaggtg accgtcactg tacctgaacc ggaagcgctc gacgtcctgg 1529761 cagagcctat ggatctggat atttattatg aggaccagga tgtgctggtc gtcaacaaac 1529821 ctcgcggaat ggttgttcac ccagcacccg ggcatcttac gggcacactt gtaaacggtc 1529881 ttatggctca ttgcacagac ctttccggaa taaatggtgt gatgcgcccg ggtattgttc 1529941 acagaatcga taaggacacg tccggtttat taatggtggc gaaaaatgat atggcgcacg 1530001 agtcactcgt aaaccaattg gtcaacaaaa cggtcacgcg gaaatatacg gcggttgtcc 1530061 acgggcttat ttctcatgat gacggcacaa ttgacgcgcc gatcggacgg gataaaaaag 1530121 accgtcaaag catgactgtg acacgtgatg gcaaaaacgc tgtcactcat tttcatgtgc 1530181 ttgagcgttt tcaggatttt acgttagtgg agtgccagct tgaaacaggg agaacccatc 1530241 aaattcgtgt tcatatgaaa tatatcggat tcccattagc aggcgatccg aaatacggcc 1530301 caagaaaaac aatcgacttt aatggccaag cgcttcacgc gggagtttta ggttttgacc 1530361 atccacgaac aggagaatat gtcgaatttg aagcgccgct tcccgaggat atggcagaat 1530421 taatcgaaaa cctcagaaaa aacggttgac agagggtttc ttttctgaaa taataaacga 1530481 agctgaatag attctttaaa acagtccaga gaggctgaga aggataacgg atagacggga 1530541 tgcgtgtata ggcgcgcacc ttgtcctaaa acccctctat gctctggcag gaggggtttt 1530601 ttcttctata tgaactgtga ggtgtcacac attgaatcaa aaagctgtca ttctcgacga 1530661 acaggcaatt agacgggcgc tgaccaggat tgctcacgaa atgatcgaac gcaataaagg 1530721 aatgaataac tgcattcttg tcggcattaa gacaagaggg atttacctgg caaaacgcct 1530781 tgcggaacgc attgaacaga ttgagggaaa tcctgttaca gtcggtgaaa ttgatattac 1530841 tctttacaga gatgatcttt ctaaaaaaac aagcaacgat gaaccgcttg taaaaggtgc 1530901 agatattccg gtagatatta cagatcaaaa agtcattctc gttgatgatg ttctgtatac 1530961 cggaagaaca gtcagagcag gaatggatgc gcttgttgat gtaggcagac cttcctccat 1531021 tcagcttgca gtgcttgtgg acagaggaca ccgggagctg ccgatccgag cggattatat 1531081 cgggaaaaac atcccgacat caaagtctga aaaggttatg gtacagcttg atgaggtaga 1531141 ccaaaacgat ctcgtcgcca tttatgaaaa cgaataatag atcacctttt taagggcaat 1531201 ccagagaggt tgcaaagagg tgcacaacaa aggcccaaaa agtattcggc aggtctttgt 1531261 atgcctcttt gcgtaaaaaa gcaaagaggt ttttttatac agtcattgag tcatcctaaa 1531321 atgaaagtca acaatcaggg ggaaatcatc atgagtaaga aaaaagtaaa tttaggggtc 1531381 agggatgtcc cgacaccttt ctcttgggtt tcattcagcc ttcagcattt gtttgccatg 1531441 tttggctcaa ccattttggt tccgaagctc gtcggaatga gtcctgctgt ggcgttggtg 1531501 acaagcggca tcggaacact ggcgtacctt cttattacca aaggacaaat tccggcgtat 1531561 ctcggttcat ccttcgcctt tatttctccg atcattctgg taaaagcgac cggcgggccg 1531621 ggagcggcaa tggttggagc gtttcttgca gggctggtgt acgggctgat tgccttattg 1531681 attaggcagc ttggaacagg atggctgatg aagattctcc cgcctgtagt cgtagggcct 1531741 gttattatcg tcatcgggct gggactggca agcactgcag taaacatggc gatgtatgct 1531801 gatccgaacg cgagtgagtt ggtctacagc ttaaagcact ttagtgtcgc aggagttacg 1531861 ctggcaatta cgattatttg tgcgattttc ttacgagggt ttttaagcct gattccggtt 1531921 ctgatcggaa tcatcggcgg atacctgttt gcccttactc aagggattgt caacttccag 1531981 ccggtgcttg acgcgaaatg gtttgcagtg cctgaattta tcattccgtt caaagattat 1532041 tcaccgtcag ttacgctcgg catcgcagcc gcaatggttc ctgtcgcatt tgtcacaatg 1532101 tcagagcata tcggccacca aatggtgctg agcaaggttg tcggacaaga cttcattaaa 1532161 aagccaggtc ttcatcgctc tattatgggt gacagtgtgg cgacaatcct cgcttccctg 1532221 atcggcggcc ctccgacaac gacttacgga gaaaacattg gcgtgctggc catcacaaga 1532281 gtattcagcg tctttgtcat cgggggcgcg gcagtgattg ccctttgctt cggctttatc 1532341 ggcaaaattt cagcgctgat cagttcagtg ccgtcagcgg tcatgggagg cgtctccttc 1532401 ctgctgttcg gaatcattgc ttcaagcggc ctgagaatgc tgattgacaa caaaattgat 1532461 tatgaaaaca acagaaacct cattattaca tcagttatcc ttgtcatcgg tgtaggaggc 1532521 gcttttatcc aagtgtctca gggcggattc caagtgtcag gaatggcgct tgccgcaatt 1532581 gtcggtgtca tcttaaacct gattcttccg caggcgaagg aagagcaggc agacacatct 1532641 gaacaacatc atatttaaaa ccttttaatg aaagtccaga gaggcttgga agggttatga 1532701 agagaaggaa gcttcaatgc tgccctctat ttaaccatac cccgagtcta tcttagaccg 1532761 gggttttttt tcagccttaa gttgaaaaga gaggggaaag aacatgaagc atttaacgac 1532821 gatgagtgaa cttagcactg aggaaatcaa agatttgctt caaacagcac aagagctcaa 1532881 aagcggaaaa acagacaatc agcttacagg aaagtttgca gcaaacctgt ttttcgaacc 1532941 gagcacgaga acgcggttca gctttgaggt cgcagaaaaa aagctgggca tgaatgtgct 1533001 taaccttgat ggaacaagca caagcgtgca aaaaggcgaa accttatatg acacgatccg 1533061 gacgcttgaa tcaatcggtg tggacgtctg cgtcatcagg cacagtgagg atgagtatta 1533121 tgaagagctt gtcagccagg tgaacattcc gattctgaat gcgggagacg ggtgcggcca 1533181 gcatccaaca caatcactgc ttgatttaat gacgatttat gaagagttca atacgtttaa 1533241 agggcttacc gtctccattc acggcgacat caagcatagc agagtggcaa ggtcaaatgc 1533301 ggaagtgttg acaagattgg gtgcccgggt cctattttcc ggcccttcgg aatggcagga 1533361 tgaagaaaat acattcggca cgtatgtctc aatggatgaa gcagttgagt cttccgatgt 1533421 tgtcatgctg ctgcgcattc aaaatgaacg acatcagtcc gctgtcagtc aggaaggcta 1533481 tttaaacaaa tacggcttga ccgtagaacg ggctgagcgt atgaagcggc atgcgatcat 1533541 catgcatcct gctccggtaa acagaggagt ggagattgat gacagcttag tagaaagcga 1533601 aaaatcaaga atcttcaagc aaatgaaaaa tggcgtattt atcagaatgg cagtgataca 1533661 gcgtgcctta caaaccaatg tgaaaagagg agaagcagcg tatgtcatat ctcattaaaa 1533721 acggctggat actaaacgaa aatggtgaaa aaacacaagc ggatatccga gtgactggag 1533781 aaaccatcac cgcaatcggc aagcttgatg caacggataa tgaaacggta attgatgcaa 1533841 aaggtttgct cgtttcacct gggtttgttg atctccacgt gcatttcaga gagccgggcg 1533901 gagagaaaaa agaaactatt gaaaccgggg caaaagcagc ggcgcgcggc ggctatacta 1533961 cagtagcagc aatgccgaat acgcggccgg ttcctgatac aaaggagcag atggaatggg 1534021 tgcaaaacag aattaaagaa acatcatgcg taagagttct tccatatgca tccattacga 1534081 tcagacaaat cggcgatgaa atgacaaact ttgaagcgtt aaaagaagcc ggggcatttg 1534141 cttttacaga tgacggcgtt ggtatacaga cagcaggaat gatgtatgaa gcgatgaaac 1534201 gggcagccgc aattgacaaa gcgattgttg cacattgcga ggacaactcc ttaatttacg 1534261 gagggagcgt acatgagggg acattctcca aagcgaacgg gctaaacggc attccttctg 1534321 tgtgtgaatc ggttcatatt gctcgcgatg tgctgctggc tgaggcggca aactgccatt 1534381 atcatgtatg ccatatcagc acaaaagaat ctgtcagagt tgtacgcgat gcgaaaaaag 1534441 cgggaatcag agtgacagca gaagtatcgc cgcatcattt gctgctttgt gatgaggaca 1534501 tcccggggct ggacacaaac tataaaatga atcctccgct ccgcagccca gaagacagag 1534561 ctgctttaat tgaaggtctt ttagacggaa caattgattt tatcgcaaca gaccatgcac 1534621 cgcatacgga agaagagaag aacacagaaa tgaagctggc gccattcgga attgtcggct 1534681 tagaaacagc attcccgctt ctttacacac actttgtcaa aaatggcagc tggtcactga 1534741 agcagctgat tgactacatg acaatcaagc catgcgaagc gttcggtctc ccatatggaa 1534801 cattacaaac ggggcaagct gcggacatta cgttaatcga tttagaaaaa gaagcagtta 1534861 tagacaaaga gacattttta tcaaaaggaa aaaatacacc attcaacggc atcagttgca 1534921 ccggctggcc ggtcgctaca attgcggcag ggaagcttgc ttatgaagag gggagacttg 1534981 tcaaatgaag agacgattag tactggaaaa cggagcggta ttcgagggag aagctttcgg 1535041 aagcttagaa cacaacatgg gagaagtcgt ttttaatact gggatgacag gctatcagga 1535101 aattttatct gatccttctt actgcggaca gatcgtaaca ttaacatacc cgcttatcgg 1535161 aaattacggc attaaccgtg atgattttga atccattacc ccttttgtca aagggctgat 1535221 catcaaagaa ttatgtgagc tgccttccaa ctggcgttca gcatacacct tagacgagta 1535281 tttaaaaatg aaaaacattc ccggactcca gggaattgat acaaggaagc tgacaagaat 1535341 gatccgcacg gcaggcgcgc taaaaggaac attcgcttca tctgatgaag atatcgaagc 1535401 agtgctgaaa agactgaacg aaacggaatt gccaagaaat caagtatccc aagtatcagc 1535461 aaaaacagca tatccgagcc cgggaagagg caaacgcatt gtcttggttg acttcggcat 1535521 gaaacacggg attctaagag agctgaacaa acggaaatgt gacgtcatcg ttgtgcctta 1535581 caacattaca gcggaagagg tgcttcagct gaaaccggac ggtatcatgc tttctaacgg 1535641 acctggagac ccgaaggatg tgcctgaagc gattgaaatg attaaaggtg ttcttggaaa 1535701 agtgccatta ttcggaatat gtctcggcca ccaattattc gcgctggcgt gcggggcgaa 1535761 tactgaaaaa atgaaattcg gccacagggg ctcaaaccac ccggtaaaag agctggctac 1535821 aggaaaagtt gccttaacat ctcaaaacca tggatataca gtttcgtcta tcagtaaaac 1535881 agaactggaa gtgacgcata tcgcaattaa cgacgatacg attgaagggc tgaagcataa 1535941 aacattgccg gcatttacgg ttcaatatca tcccgaagcc tcacctggtc ctgaggatgc 1536001 caaccatcta tttgacagat tcatcgaaat gatcgaaaca acagagaaag aaggggaagc 1536061 ggtatgccaa aacgcgtaga cattaacaaa attttagtaa tcggatctgg accgatcatc 1536121 atcggccaag cagcagaatt tgactatgcg ggaacacaag cctgtcttgc tttgaaagaa 1536181 gaaggctatg aagtcatcct tgtcaactca aaccctgcaa cgatcatgac agatacagaa 1536241 atggctgacc gggtttacat cgaaccgctc acacctgaat tcctgacacg aatcatcaga 1536301 aaagagcgcc cggatgccat tcttcctaca ctcggaggcc aaaccggttt gaatcttgcg 1536361 gttgagcttt ctgaaagagg cgttttggca gaatgcggcg tcgaagtgct tggcacgaaa 1536421 ctgtctgcga ttcagcaagc tgaagaccgt gacttgttca gaacattaat gaatgaactg 1536481 aatgaaccgg tgcctgaaag tgagattatc cactcccttg aagaagcaga aaaattcgtc 1536541 agtcaaattg gattccctgt cattgtccgc ccggcatata cattaggcgg aacaggcgga 1536601 ggcatctgct cgaatgaaac agagctaaaa gaaatcgttg agaacggctt gaaattaagc 1536661 ccggtacacc aatgtctgct tgaaaaaagc atcgccggct ataaagaaat cgagtatgaa 1536721 gtcatgagag acagccagga tcacgccatt gtcgtttgta acatggaaaa cattgatcca 1536781 gttggaatcc atactggaga cagtattgtt gtcgcgccga gccaaacgct cagcgatcgc 1536841 gaatatcagc tcttgcggaa tgtatcgtta aaactgattc gcgcgcttgg gatcgaaggc 1536901 ggatgtaatg tccagctcgc cttagatcca gacagcttcc aatattacat tattgaagta 1536961 aatccgcgtg tcagccgttc atctgccctt gcatcaaaag caacggggta cccgattgca 1537021 aagctcgctg ctaaaattgc agtcggactt tcattagatg aaatgatgaa cccggtgaca 1537081 ggaaaaacat atgcagcatt tgaacctgct cttgactatg tcgtatccaa aattccgcgc 1537141 tggccgtttg ataagtttga atcagcaaac agaaagcttg gcacgcaaat gaaagcgaca 1537201 ggtgaggtca tggcaatcgg ccgcacgctt gaagagtcat tgctgaaggc agtgcgatca 1537261 ctggaagcgg atgtgtatca tcttgaattg aaggacgccg ctgacatttc agatgagctt 1537321 cttgaaaagc gaattaaaaa ggccggtgat gaacgcttat tctacttagc tgaagcgtac 1537381 agaagaggct acacggtaga agacctccat gaattttccg ctatcgatgt cttcttcttg 1537441 cataagctgt tcggaatcgt acagtttgaa aaagaattga aggccaatgc gggcgataca 1537501 gatgtgctga gacgggcaaa agaactcggc ttctctgatc agtacatcag ccgtgaatgg 1537561 aaaatgaaag aatctgagct ttacagcttg agaaaacaag cggggattgc gccggtattc 1537621 aaaatggtag atacatgcgc ggcggaattt gagtcagaaa cgccatactt ctatagcaca 1537681 tatgaagaag aaaatgaatc tgtcgttaca gataagaaaa gtgtgatggt gcttggttcg 1537741 ggtccgattc gaatcggtca gggtgtcgag ttcgactatg cgacggttca ctctgtatgg 1537801 gcaattaaac aagcaggcta tgaagccatt attgtcaaca acaacccgga aaccgtttca 1537861 acagacttca gcatctcaga caagctgtat tttgaaccgc ttacgattga agatgtcatg 1537921 cacatcattg acctcgaaca gccaatgggc gttgtcgtac aatttggcgg acaaactgcg 1537981 attaaccttg ctgacgagct ttctgcacgc ggagtgaaaa tccttggaac ttcattagaa 1538041 gatttagacc gtgccgaaga ccgggataaa tttgaacaag cgcttggaga acttggtgtt 1538101 cctcagccgc ttggcaaaac agcgacatca gttaatcagg cggtaagcat cgcaagtgat 1538161 atcggttatc cggtactggt acgcccttcc tatgtacttg gcggccgggc gatggagatt 1538221 gtttaccatg aagaggaact gcttcattac atgaaaaatg cagtcaaaat caatccacag 1538281 caccctgtat taattgatag atacttgacc ggaaaagaaa ttgaagtcga tgcagtatcc 1538341 gacggtgaaa cagtcgtcat tccgggaatt atggagcaca ttgaacgtgc gggcgttcac 1538401 tccggagact caatcgctgt ttatccgcct cagtctctca cagaggacat taagaaaaaa 1538461 attgaacaat acacgatcgc attggctaaa gggctgaata ttgtcggttt gctcaatatt 1538521 caattcgtct tgtcgcaagg cgaggtgtac gtgctagaag tgaatccgag atcaagcaga 1538581 accgtaccgt ttttaagcaa aattacgggt atcccaatgg cgaatctcgc aacaaaaatc 1538641 attcttggtc aaaagctggc tgcgtttggc tatacagagg gccttcagcc tgaacagcaa 1538701 ggtgtatttg taaaagcgcc ggtcttctcc tttgccaagc tgagaagagt ggatattacg 1538761 ttagggcctg aaatgaaatc aacaggtgaa gtcatgggga aagattcgac acttgaaaag 1538821 gcgctctaca aagccttgat cgcttcaggt attcaaatcc cgaactacgg ttccgtgctt 1538881 ttaacagtag ctgataagga caaagaagaa gggcttgcca ttgctaagcg gttccacgcg 1538941 atcggctaca acattttagc gacggaagga acggcaggct acctgaaaga agcttccatt 1539001 ccagcgaagg tcgtcggaaa aatcggtcag gatggcccga acttgcttga tgtcatcaga 1539061 aacggagaag cgcagtttgt catcaatacg ctgacaaaag gaaagcagcc ggcaagagac 1539121 ggttttagaa tcagacgtga atcagtagaa aatggtgttg cctgcctaac atctttagat 1539181 acggcagagg cgatattgcg agtgctggaa agcatgacat tccgtgctga tcaaatgccg 1539241 gcagtcaaca caaatcagga ggcggcagtc actatatgaa aaaagcgtat ttgacagtat 1539301 gttctaacca gcaaattgca gaccgggtgt ttcaaatggt tctgaaaggg gagcttgtcc 1539361 aagggtttac aacccctgga cagttccttc atcttaaagt gagcgaagcg gttacgcctc 1539421 ttttgagaag gccgatcagc atcgcagacg tcaactttga aaaaaatgaa gtcaccatca 1539481 tttatcgggt agatggggaa gggacaagac tcttgtcact gaagcagcag ggagaacttg 1539541 tggatgtcct cgggcctttg ggaaatggct ttcctgttaa tgaagttcaa cccggaaaga 1539601 cggctttgct ggtaggaggc ggagtaggtg tgccgcctct ccaagagctg tcgaaacgct 1539661 tgattgaaaa aggggtaaat gtcatccacg ttttaggatt ccaatcggca aaggatgttt 1539721 tttacgagga agaatgccgg cagtacggag acacgtatgt ggcaacagct gacggaagct 1539781 acggggaaac cggatttgtc acagatgtga ttaaacggaa aaagctagag tttgatatcc 1539841 tcctcagctg cgggccgaca ccgatgctca aggcgttaaa acaggaatat gcccataaag 1539901 aagtatatct gtccatggag gaacgaatgg gctgcggaat cggcgcatgc ttcgcgtgtg 1539961 tgtgccatac aaacgaaagt gagacatcct atgtaaaagt atgtctcgac gggcctgtat 1540021 ttaaagctca ggaggtggcg ctgtaatgct agaggtgaaa ttgccgggac ttgatttgaa 1540081 aaacccaatc attcctgcat caggctgctt cggttttgga aaagaatttt cacgttttta 1540141 tgatttgtct tgtcttggag ctatcatgat taaggctacg acaaaggagc cgcgctttgg 1540201 gaatccgacg ccgcgggtag ctgagactgg tgctggaatg ctcaatgcga tcggtctcca 1540261 aaatccgggg ctggatagtg tgttgcatca tgagctgccg tggcttgagc agtttgatac 1540321 accgatcatt gccaatgtcg caggttctca agtcgatgat tatgttgaag tcgcagaaca 1540381 tatcagcaaa gcgcctaatg ttcatgctct tgaattgaat atttcctgcc cgaatgtgaa 1540441 aacaggcgga atcgcttttg gcacgaatcc tgaaatggct gccgatttga caaaagcggt 1540501 gaaagaggtt tcggatgtac ccgtttatgt gaagctatcc ccgaacgtgg ctaatatcac 1540561 agaaattgca ttagcgatcg aggaagcggg agcggacggt cttacgatga tcaacacact 1540621 aatcggcatg agactcgatt taaaaaccgg caaaccgata ttagcgaata aaacaggggg 1540681 actttcgggc cctgctgtga agccggttgc cattcgcatg gtgtatgaag tcagccagat 1540741 ggtcaacatc ccgattatcg gaatgggagg cgtgcaaacg gctgaagatg ccctggaatt 1540801 tcttctcgcg ggagcaagcg cagtcgctgt cggaacagca aactttgtga atccttttgc 1540861 atgtccagag attattgaac agctcccatc tgttttgctc caatacggct atcaatcaat 1540921 tgaagaatgc atcggaagga gctggaatca tgaaaaacaa cctgcccatc atcgcgcttg 1540981 attttgcgtc agctgaagaa acacttgcgt tcttagcgcc ttttcagcaa gaaccgttat 1541041 ttgtaaaggt tgggatggag cttttttatc aagaagggcc atctatcgtg aaacaactaa 1541101 aagaaagaaa ctgcgagcta tttttagatc taaagcttca tgacatcccg actactgtaa 1541161 acaaagcgat gaagcgcctt gccagtcttg gagtagacct cgtcaatgtt catgctgccg 1541221 ggggcaaaaa aatgatgcag gcagctctcg aaggcttaga agaaggtacg ccggctggaa 1541281 aaaaacgtcc gtcacttatc gcggtaaccc agctgacaag cacatctgaa caaatcatga 1541341 aagatgaact gctgatcgaa aagtctctga ttgatacggt tgtgcactac agcaaacagg 1541401 cggaagaaag cggactggat ggagtggtct gctctgttca tgaagcaaaa gccatttacc 1541461 aagcggtgtc gccttcattt ctgactgtca ctccggggat cagaatgtca gaggacgctg 1541521 cgaatgacca agttcgcgta gcgacgcctg ccattgcaag agagaaaggt tcatcagcga 1541581 ttgtagtagg acgctcgatt acaaaagcgg aagacccggt aaaagcctat aaggctgtca 1541641 gacttgaatg ggagggaatc aaatcttgaa acaaatcatc gcaaaacatc tattagacat 1541701 ccaagctgta tttttacgcc cgaacgagcc gttcacatgg gcaagcggca ttttatcacc 1541761 gatctactgt gacaaccgcc ttacgctatc tttcccagag gtcagaaacg atgttgcttc 1541821 aggtatcagc aagcttgtta aagagcattt tcctgaagct gaaatgattg cgggaacagc 1541881 aactgccggt attcctcatg ctgctcttgc ggcggaccat ttgaatcttc cgatgtgtta 1541941 tgtgaggagc aagccgaagg cgcacggaaa aggcaatcag attgagggag ctgtgcaaga 1542001 agggcaaaaa acagtcgtca ttgaagactt aatttccaca ggaggcagcg tgcttgaagc 1542061 ttgtgcagct ttacaagcgg ccggctgtga agtgcttggt gtcgtctcaa tctttacgta 1542121 cggacttcct aaagcggagg aagccttcgc aaaggcagaa ctgccatact actcattaac 1542181 cgattatgat acgctcacag aggtcgcgct tgaaaacgga aatattcatt cagatgatct 1542241 aaaaaagctg caaacatgga aacgaaatcc cgagtcaaaa gattggttta aaaaataaaa 1542301 aataaattca aatgatgtaa agaggcttca aagccttgct gtacttgaaa acaggctgtg 1542361 aggcctgttt ttttattaat cctataaaaa aagtcgggtt gacttatgtt agaattgtgc 1542421 taaaatttac tacaaatcta aaaacttatc aagagcggct gagggactgg acctatgaag 1542481 cccggcaacc tgcatagttt gtaaggtgct acttccagca aaatgaattc cattttgaaa 1542541 gataagggct gcatgctgtt cctgtctttc tttccgccgg attgaaagtt ttttatttta 1542601 agaggtaaaa aggctatctg tatatcagca gccgcgaatc acattacatg ggaaaagaca 1542661 accggcagaa agctactgtt tgtttgtctc cgaaaggagg aaagaagaaa tgttaacgta 1542721 tgataattgg gaagaaccaa cgattacatt tccggaagac gatccttata aaggagcgct 1542781 gtcagtttta aaatgggcat acggccatta cggcgatcag cttgtttatg cctgcagttt 1542841 cggaattgag ggaatcgttc tgattgactt aatttataaa gtgaaaaaag acgcagagat 1542901 tgtgtttctt gatacaggac ttcattttaa agaaacctat gaaacaattg aacgagtgaa 1542961 agagcgttat ccgggtctta atatcatcct gaaaaaacca gatctcaccc ttgaggaaca 1543021 agccgaagaa catggtgaca aactatggga aagagagccg aatcagtgct gctatcttag 1543081 aaaggtcgtt cctttaagag aggcgctttc aggacatcca gcctggcttt ccggcctgcg 1543141 ccgtgatcaa gggccaagcc gtgccaatac gaatttctta aacaaagatg aaaaattcaa 1543201 gtcagtaaaa gtttgcccgc ttatccattg gacttggaaa gacatttgga gatatacatc 1543261 ccggaatgaa ctggactaca atccgcttca tgaccaaggc tatccaagta ttggctgtgc 1543321 gccttgcact tctcccgctt ttacagcaga agatttgcgc tcaggcagat ggaatggtat 1543381 ggcgaaaaca gaatgcggac tgcatgaata aggagctgca aaatggaatt agccgctatt 1543441 ttatttagct tgtttttcgc gatgaatatt ggtgcaagcg gcgctgcagc ttcgatgggg 1543501 gttgcttacg gctccggagc catcaaaaag aaaacttacg ctttgatcct atgcgcagtc 1543561 ggtgtctttg ccggggcggt cattggcgga ggcgaggttg taaaaacaat cagctccggc 1543621 attattcctg agcagacgat tacactgacg attgtttgca tcattattgg agctgctgcc 1543681 ctgtcgctct ttactgctaa tctgctcggc attcctttgt cgacaagtga agtaacagtc 1543741 ggcgcggttg tcggcgtggg agtggcttat aaagtattgt ttgtgaacaa tcttctgatc 1543801 attgtgtcat tttgggtttt tgtcccgctg ttcgctttcg gcttcaccta tttcgtatct 1543861 aagctgtttc gttattttaa gattgaagta aaatcttcta aaaagcaaaa aatcctcggc 1543921 attgttttgt tagttgccgg atttttcgaa gcattctctg ccggcatgaa taacgtggcg 1543981 aatgctgttg gcccgttagt agctgccggt gtgcttgatg tcggaaaagg aaccttgtat 1544041 ggaggagctt ttgttgctct tggcgcactg ttattaggcc ggcgagtgct agaaacaaac 1544101 gggaagaaaa ttacgaggtt ctccaaaggg gaaggcattc tcttatccgg tacaggagcg 1544161 ggactggtga tcatcagttc tgtatttggg atgccggtgc ccttggcgca agtcacgtca 1544221 tcgtctatta tcggaatagg catggcgaaa aacggtccga acgtgttcca taaacaagtt 1544281 gttcaaacga tgctgaaggt atggatcgta tcgccgtttt tatctttatc gatttcttat 1544341 ctgcttgtat ccttgttttt aaaagcagat tattattcga tctttatcat ggtaagtgtg 1544401 cttttagcgg cgggcggtgc catcagcctg acaaaggcca ttcgtaaaga gagacgctca 1544461 gtccacgaac aaggcggggg aatctgatca ttaatctgag taattttata agttaactag 1544521 gaggagatgg atattatgag cttagcacca cacggaggaa cattagtaaa cagagtagat 1544581 gaatcatatg atgtgagcgg cattcaaaaa gaaattgaac ttgatttaat ttctttcgcg 1544641 gatttggaat tgatcggtat cggtgcatac agcccgattg aaggtttctt taatgaaaaa 1544701 gattacgtat cagtggtcga aaacatgcgt ctttcttccg gcgttgtctg gtctcttcca 1544761 atcacgcttc cggtcgatgc gcaaaaagca gcggaactgt cacttggtga aacggtaaag 1544821 ttaacgtatg aaggagaaac ttacggcgtt atccaaatcg aagacctgta cgtgcctgac 1544881 aaacaaaaag aagctgtcaa tgtgtacaaa acagatgaac aggagcatcc tggtgttaaa 1544941 aagctgttca gccgcggcaa tacatatgtc ggcggaccga ttacgttgat taaaaaagct 1545001 tcaaaacagt tccctgaatt tacatttgaa ccgtcagaaa cgagacgcca gtttgcggaa 1545061 aaaggctggg aaaccattgt cggtttccaa acaagaaacc ctgttcacag agcgcatgaa 1545121 tacattcaaa aaacggctct tgaaacagta gacggcttgt tcttgaatcc gttagtaggt 1545181 gaaacaaaat ctgatgacat tccagctgat gtacggatgg aaagctacca agtgcttctt 1545241 gatcattatt acccgaaaga tcgtgttttc cttggtgtct ttttagcggc gatgcgttat 1545301 gcaggcccga gagaagcaat tttccacgcg cttgtcagaa agaactacgg ctgcacacat 1545361 ttcatcgtcg gccgtgatca tgcaggtgta ggcgactatt acggaacata cgaagcacag 1545421 gaactgtttg acacatttaa acctgaagaa ctcggaatta caccgctgaa atttgagcac 1545481 agcttcttct gtaaaaaatg cggaaatatg ggaacagcaa aaacttgccc tcatggcaga 1545541 gagcatcacg tcattttatc aggcactaag gtaagaggta tgctgagaga cggtgtgctg 1545601 ccgcctgctg aattcagtcg aaaagaagta gtagaagtgt taatcaaagg gatgaagaaa 1545661 aaagaagaag taggcgtatc ttaaggagga ctggcagtga caaatcgcga tattgtatgg 1545721 catgaagcct ctatcacaaa agaagagtat cagcaaaaaa acaagcataa aagctccatt 1545781 ctctggctga cagggttaag cggctcaggc aaatcaacca ttgccaacgc cgctgcgaga 1545841 gaattgtttg agcaaggcta ccaagtcatt gtgctggacg gggataatat ccgtcacggc 1545901 ctaaataggg atcttggttt ttctgatgaa gaccgaaaag aaaacatccg ccggatcgga 1545961 gaggtggcga agctttttgt tcagcaggga accattgtga ttactgcttt tatctctcct 1546021 ttccgcgagg acagacaaca ggttcgcgag cttgtggaag cgggcgaatt taatgaagtc 1546081 tacattaaat gcgaccttga tatttgtgaa caaagagatc cgaaagggct ttacaaaaaa 1546141 gcaagaaacg gcgagattcc gttctttaca ggaattgatt ctccttatga agaaccggaa 1546201 gctccagagc tcgttcttga ttcaggacag catgaccgtg aagcgtgtaa aaatcagctg 1546261 atcgagtttg ttaaacaaaa attgagctga atatgatctg ctgcgttctt ctcagatgcc 1546321 ggaatgcaag cgagaacatc atcacagcga atcttctgga agaactcgaa tagatcgggg 1546381 gaaatacgat ggggaaagta tatattgtag gagcgggtcc cggtgaccct gatctgctga 1546441 caattaaagc gctgaaagcc attgaaaaag ctgatgtcat cttatatgac agattagtaa 1546501 ataaagagat tttacaatat gccaaagagc aagcagacct gatctactgc gggaagcttc 1546561 cggattttca tacgatgaag caggaaacca tcaatcgatt tcttgtgaag tatgcgcaaa 1546621 aagggaaaat ggttgtcaga ctgaaaggcg gagacccttt tgtgttcggg agaggagggg 1546681 aagaagcgga atgcctctct gaaaatggaa ttccgtttga aatcattccc ggcattacgt 1546741 ctggaatcgc ggcagccgct tatgccggga ttcctgttac ccatcgggat gcgggctcta 1546801 acgtcgcttt tgtaacgggt cactataaaa aagaagaaga ttttgaggaa aagtggaaag 1546861 cgctggctac aggaattgat acacttgtca tctatatggg tatcaaaaac gtgcagcaga 1546921 ttgaaagaaa actccttgaa aatggccggg acggttctac gccagcagcc tttattcatt 1546981 gggggacaac ggacaagcaa aaatctgttt tttgtacagt tgacaccctt tcagaaacgg 1547041 tgataaaaga aaacattaca aatccgagtt taattgtcat tggaaatgtt gtaaattatc 1547101 actataagct ggaatggttt gaatctgaac taaaaaaaca agatttaagc gaggcgttgt 1547161 aaaaatgaaa caagcaattt tatatgtcgg ccacggcagc cgggtcaaaa aagcgcagca 1547221 agaagccgca gcctttttgg aaggatgcaa ggcccacatc tctgtgccag tacaagaaat 1547281 cagcttttta gagcttcagg agccgacaat tgagacagga tttgaagcat gtgtgaagca 1547341 aggtgccact catatcgcag tggtgcctct gcttctttta acagctgcgc atgcaaaaca 1547401 tgatattccg gaagaaattg tccgtgttgc atctcgatat ccatcagtcc gtatttcata 1547461 cggaaagccg atcgggattg acgaagaagt agtcaaggct gtatatcacc gaatgaaaga 1547521 cataggtgtt ccgtatgaaa atgccagagt ggtgctcatc ggaaggggaa gttcagatcc 1547581 agacgtcaaa agagacgtaa ccggaattgc taatcttctt caggaaatgg ttccagtgaa 1547641 ggaagtcatt ccgtgctttt tgacagcatg cggccctaat tacaaagagg ttttttcaga 1547701 acttgaaaaa gatgacggca taacaacctt tatcgttcca tatttgcttt ttacgggtat 1547761 gctgatgaat gaaatcgaac gagaggttca gaaattaaaa gcccataatc cgaacgtcta 1547821 cctctcttcc tatatcggtt ttcatcctca tgtgaaaaac gcatttttga accgtgtgag 1547881 agaaactgcg gcaaattctg agggacaatt tgattttgat ggaggttcat atgcttccgc 1547941 tgcacattag cctggaaaag aagaaggttg tgattgcggg gggcggaagc atcgctctca 1548001 gaaggctgaa aacggtgatt tctgagggag ctgatataac gcttgtcagt ccggatgtgg 1548061 aaccggaaat caagcaaatg gcagaagagc ggcgtatcaa atgggaaaaa cggacaattg 1548121 aaaaagaaga ttatctcaat gctttcttca ttattgctgc gacggataat gcggcagtga 1548181 acaaagaaat tgcccaatcc gcttcgcctt ttcagcttgt caattgtgtc agtgacgctg 1548241 agcttggcaa tgtatatatg ccgaaaatcg taaaaagagg gcatgtcact gtgtctgttt 1548301 ctacaagcgg agccagtcca aagcacacga aagagcttgc tgaaaacgtg gataagctga 1548361 ttgacggcga ttttgttgct gaagtgaaca ggctttatca gatgagaaga aagaaataag 1548421 ccagagcata caaatgctct ggcttttctt tatgcggctc agcttttttt gagcttgatg 1548481 acagtatcag catcaggcgt gacaaagacg gtatgctggc tgtcataagt gacgaaaccg 1548541 ggtttcgcgc cgtttggttt tttgacatgc ctgatttttg tataatctac aggcactgaa 1548601 cttgaatctt tagcttttga aaaataagct gcaattgtcg cggcttccat gattgtttgc 1548661 tcatcaggtt cgctgcttct gatcacaacg tgggagccgg gaatgtcctt cgtgtgaagc 1548721 cagatatcgt ctctggccgc cactcttgtc gttaaatatt cattttgacg attgttctta 1548781 cccactaaaa ttgtcagccc tgaggtggat tcatatgttt ctaacaccgg attgtgcggt 1548841 ttttgctttt tctggccttt ttgctgctta gggcgtaaat atttgccctc aacaagctct 1548901 tccctgattt cgctgatatc ccggggagaa gcggacgaaa gctgctgaat cagctgatca 1548961 aaatattcga tctcttcctg tgccagcctg atttgctcct cgacaactgc gaccgaattt 1549021 ttcgctttct gatacttcgt gaaataggcc tgtgcgtttt cagaaggcgt tttgttcggg 1549081 tttaaaggaa tcgtgattgt cgggctttct tcatcataat aattgatgac ctcagcctgt 1549141 ttatcacctt ttttcagcat atataaatta gcggttaaaa gctctccgta aagctgaaat 1549201 tccttcgcgt tttccgaata ctccagggtt ttctctaatt ttttgatttt gttggcattc 1549261 ttcttccgtt cgttcacaac aaaacgctca agatcctgag cctgttgctt aacccggtct 1549321 cgttcagctt ttccgaaata aaaacggtcg agcagttcgc ttaatgaatc aaaacggcgc 1549381 gcttcgccct ttagatgagt cagctccagc agataaaaat attcctttcc gtttacagtc 1549441 gtaatgttgg gaatgaaacg gtgctctttc acttcggcaa acagtgccag caacgctttt 1549501 ggcagtgtga ctttgttggc aaggcctgct ctgtgaaccg cttctttggc gaaaagcgga 1549561 gacacgcctg aaaagtggtc gacaatttgt ttatcaagcc ttccttcttg aaagctgagg 1549621 tgacgcaaaa tatcatcttc tgacgcctca agaggcgata ttttgtcctg agcaggcgga 1549681 agcttataat cttggccggg cagtactgta cggtagctgt tcattgacgg tgataaatgc 1549741 ttaagtccgt cgataatcac attttctgct gcgtcagtca aaatgatatt gctgtggcgg 1549801 cccataattt ctacataaag ctttcgtacg gtttcatcgc caatttcgtt tcggcttttg 1549861 atatgaaaaa tcataatgcg gtctaagccc gcttgttcaa ttttctcaat gaatccgcct 1549921 tcgatatgct ttctcagcaa catgcaaaac attggcggtt cgcttggatt ttcataagct 1549981 tgtgccgtga tatgcacccg tgaatagctc ggatgtgccg ataataatag tttttggttt 1550041 tttcccttgg cacggatgtg gaaaatcaca tcgtgcttat atggctgatg gatttttgta 1550101 attcgtccgc ccattatttt ctcgttaagt tcgtgtgtca ttccgtatgt aaacatgcca 1550161 tcaaacgaca tatgcaatac accctctcat tcttcctgca ttcgataatt atagcatgaa 1550221 atgggacgag tcagaataag catgcttata gagtgatatc tctataagag agcaggggag 1550281 tggacgagcg gaatgaagtt tcatgaaatg ggacaaacag atttactaga ggcaaccaat 1550341 acgtccatga aacaaggatt aacagaaaaa gaggtaaaaa aacgccttga caagcatgga 1550401 ccaaacgagc tgcaagaagg gaaaaaaact tcagcgcttc tcttgttttt cgcgcagttc 1550461 aaagatttta tggtgcttgt gcttctggcg gcaacgttaa tctcaggatt tcttggtgaa 1550521 tatgtagatg cggttgcgat tattgcgatt gtgtttgtga atggcatact cggtttcttt 1550581 caagaaaggc gtgctgagca atctcttcag gctttaaaag agctttcaac accgcacgtc 1550641 atggcactca gggaaggaag ctggacaaag attccttcta aggaactggt gccgggtgat 1550701 attgtgaaat ttacgagcgg ggacagaatt ggcgcagacg ttcgaattgt tgaagcgaga 1550761 agccttgaaa tagaagaatc agcgctaacc ggggaatcaa tcccggttgt gaagcatgct 1550821 gataaattga aaaaaccgga tgtttcactc ggcgatatta ccaatatggc atttatgggt 1550881 acgattgtga cccgcggcag cggtgtcggg gttgtcgtcg ggacaggaat gaatacggct 1550941 atggggaaaa ttgccgacat gcttgaatcg gcagggacat tgtcaacccc gctgcaaaga 1551001 agactggagc agctcgggaa gattttgatt gttgttgcat tgcttctgac cgtacttgtc 1551061 gttgctgtcg gtgttattca gggtcatgat ctgtacagta tgtttttagc aggtgtctcg 1551121 ttagcggtag ccgctattcc ggaggggctg ccggcgattg tgacagtggc gctttcgctt 1551181 ggtgtacaga ggatgattaa acaaaaatcc attgttagaa agcttcctgc tgttgaaacg 1551241 cttgggtgtg cgtctatcat ttgctcagat aaaacaggga caatgaccca aaacaaaatg 1551301 acagtgacgc atgtctggtc cggagggaaa acatggagag tggcaggggc cggctatgaa 1551361 ccgaaaggaa gcttcacact aaacgaaaaa gagatcagtg tcaatgaaca taagccgctt 1551421 cagcagatgc ttctgttcgg agcgctttgt aacaactcca atattgagaa aagagacggc 1551481 gaatatgtgc ttgacggaga tccgacagag ggagcgctgc tcaccgcggc aagaaaaggc 1551541 ggtttttcaa aggagtttgt tgaatctaat tacagagtga ttgaagaatt tccgtttgat 1551601 tccgcacgga aaatgatgac tgtcatcgta gagaatcaag acagaaagcg ctatatcatt 1551661 acaaaaggtg cgccggatgt actcatgcag cgatcttccc gtatttatta tgatggctca 1551721 gcggctcttt tttcaaatga aagaaaagca gaaacagagg cggtattaag acatttggca 1551781 tcacaggcgc tcagaacgat agcggtcgcc tacaggccga taaaagcagg cgaaacaccg 1551841 tcaatggagc aggcggaaaa agatctgacc atgcttggcc tttcaggtat cattgatccc 1551901 ccgcggccgg aagtcagaca ggcgattaaa gaatgccgtg aagcgggaat taagaccgtc 1551961 atgattacag gtgatcatgt agaaaccgct aaagcgatag cgaaagactt gcgcctcctt 1552021 ccgaaaagcg gcaaaatcat ggacggcaag atgctgaatg aactttctca agaagagctt 1552081 tctcatgtgg tggaggatgt gtatgtattt gcccgcgttt cccctgaaca taaactaaaa 1552141 atcgtaaaag cctatcagga gaacgggcat attgtggcga tgacgggaga cggcgtcaat 1552201 gatgctcctg ccattaaaca ggctgatatc ggcgtctcta tgggcattac cgggacagat 1552261 gtggccaaag aagcatcatc tcttgttctc gtggatgata attttgcgac gattaaatca 1552321 gcgataaaag aaggcaggaa catctacgaa aatatcagga agtttatcag atacctgttg 1552381 gcgtctaacg tcggagaaat ccttgtcatg ctgtttgcga tgctgcttgc ccttccttta 1552441 ccgctggttc cgattcagat tttgtgggtc aacttggtga cggacggatt gccggcaatg 1552501 gcgctcggca tggatcagcc ggaaggagac gtcatgaagc gcaagccccg tcatccgaaa 1552561 gaaggggtat ttgcccgcaa gctaggatgg aaggtcgttt ccagaggatt tttaatcgga 1552621 gttgccacta ttttagcgtt tatcattgtg taccaccgca atccggaaaa cttggcttat 1552681 gcccagacga tcgcgtttgc cacattggtg ctcgctcagc ttattcacgt gtttgactgc 1552741 cgcagcgaaa cttctgtttt ctctagaaat ccgtttcaaa acctgtattt aatcggcgcg 1552801 gtattgtcat ccattttgct gatgcttgta gtaatctact atccgccgct tcagccgatt 1552861 ttccatactg tagccatcac gccgggggac tggatgctcg tcatcggtat gtccgccatc 1552921 cctacttttt tgctggcggg gtcactttta acaagaaaaa aataaattca tatgatataa 1552981 tcttaggggt aatagcgtgt ctattgccct tttattatga gaacagggaa gaattgggtg 1553041 ttttaaaatg atacgaagta tgacaggctt cggcagtgca agcaaaacac aagacgatct 1553101 ctctgtaagc gttgaactta aatctgtgaa ctacagattt aaagaagtga acgctcgttt 1553161 gccaaggcct ttgctatatt ttgaagataa gctgaaacag accattctgc agcatattca 1553221 gcgcggaaga attgagcttt tcgtatccgt tgacagcgat atgcttgttg agaaaaggct 1553281 tgaaattgat tggccgctgc tcgatgagtt tgtcgcagcc gcgagagata tgaagaagcg 1553341 gtatcaattg tctgcagagc ccgatgtaat ggatttcttt aagcttgatc atgtcgtcca 1553401 ggttcatgaa gaacagacgc aaaatgacaa gctggaggcg ttgatcatcg atgctgcaga 1553461 agaagcggta aaaggtctct gtgaaatgcg tgaaaaagag gggctgctct tagcgaaaga 1553521 ctgcctgatg catattgatc agcttgaaga gctggtgaga gaaactgaat tgctggctgc 1553581 agatgtcgta tctcgttacc gggaacggct gtatgccaga atcaaagaat ggactgaaga 1553641 cgtattagac gagagccggc ttgtaacaga atgcgctatt tttgcagacc gctctgatat 1553701 cactgaagag attacaaggc tgaagagcca cttcgcccag tttcgtgata tattagctag 1553761 tggcggagct gtcgggcgca aactcgactt tcttgttcag gagctcaatc gggaagcaaa 1553821 tacgatcggc tcaaaagcaa atgatcatca gatcacaaag cttgtcgttg aaatgaaaag 1553881 ttctattgaa aaaataaaag aacaagtgca aaatatagaa tagtgactgt gcgtattgtt 1553941 tacagacggt cttactaggc taaactagag acgtctattt tacaggggga acgtagaaga 1554001 tgacgattaa actgattaat atcggatttg gcaatatcat ctccgccaat cggatgattt 1554061 cgattgtcag cccggagtct gcgccaatca aacggatgat tcaggatgca agagaccgcg 1554121 gaatgctaat tgacgctaca tacggacgaa gaacccgtgc agttgtcgtc atggatagtg 1554181 atcacattat cttatctgcc gtccagcctg agacagttgc acacagactt tctgttaaag 1554241 aagaaattat ggatgaaggg caggggtaat tgccgcatga aagaaagagg gttattaatc 1554301 gttctctcag gtccctcagg agttggtaaa ggaacggttc gacaagcgat cttttcgcag 1554361 gaagacacaa aatttgaata ttcgatttca gtaaccacaa gaagtccaag agagggcgaa 1554421 gtgaacggag tcgattattt tttcaaaaca agagacgaat tcgagcaaat gattgcggac 1554481 aacaagctgc ttgaatgggc agagtatgtc ggcaattatt acggcacgcc agtcgattat 1554541 gttgaacaga cgcttcaaga tggaaaagac gtctttttag aaattgaagt tcaaggggct 1554601 cttcaagtga gaaatgcttt cccggaaggc ctgtttattt tccttgcgcc tccaagcctt 1554661 tctgaactga aaaacagaat cgtgacacga ggaacagaaa cagacgctct gattgaaaat 1554721 cgaatgaaag ccgcaaaagc tgagatcgaa atgatggatg cttatgacta tgtcgttgaa 1554781 aacgataatg tcgaaacggc ttgcgataaa atcaaagcaa tcgttcttgc tgaacatttg 1554841 aagcgtgaac gcgttgcacc aagatataag aaaatgctgg aggttgaata atcaatgtta 1554901 gatccgtcaa ttgattcttt aatgaataaa ttagattcaa aatatacgct ggtgactgtt 1554961 tctgcgagac gtgcccgtga aatgcaaatc aaaaaagacc aaatgattga acatacgatt 1555021 tcacacaaat atgtaggcaa agctttagaa gaaattgatg caggcctgct ttcgtttgaa 1555081 aaggaagacc gcgaatagta gcacaagtag caacctatat catgtaggtt gttatttttt 1555141 tccgtgcggt tttgtaaagt gcagaggggg agaattcatt gcttaacaat cgaaatgtgt 1555201 tactttgcgt gagtggaggc atcgctgttt ataaagcctg tgcgttaacg agcaagctgg 1555261 ttcaggcagg agcaaatgtc aaagtgatta tgactgaatc cgcttgccga ttcgtttcac 1555321 cgctgacatt tcaggcattg agccgccacg aagtctatac agatacattt aaagaacaaa 1555381 atccaagcgt catttctcat attgatgccg cagactgggc cgacttgatt atcgtagcgc 1555441 cggctacggc taatgtgatt ggaaaactgg caaacggcat cgctgatgat atgctgacga 1555501 caacattgtt ggcagcaacg gctcccgttt ggatcgcgcc ggcaatgaac gttcatatgt 1555561 atgaccaccc ggcagtcaaa cgaaacattt ctgttcttta tcaggacggt tattgtttta 1555621 ttgagccaag tgagggctat ttagcatgcg gttacgtagg aaaaggcaga ttggaagagc 1555681 cggaaaacat cgtaaagctg gccgaaaaac attttgctga agaaacatcc gctcctttag 1555741 aaggcaagca tgtggtcatt acagccggcc caacgcggga agcgattgat cctgtccggt 1555801 tttttaccaa taaatcgacg ggcaaaatgg gctacgcact ggcggaggct gctgttcagc 1555861 tcggcgcacg ggtaatctta atttctgggc ctgtttcact tgatcagcct aaaggccttg 1555921 ctgagtttat ccctgttcaa tcggctgcgg atatgcgcga agctgtgctc tctgtgtatg 1555981 acgcaagcga tatagtcatt aaaacagctg cggtagccga ttttacgccg aaaacagtat 1556041 ttgaccataa aatgaaaaaa caagacggcg gcatgacctt agaactgaaa agaacagtcg 1556101 atattttgaa agaattgggc gagaaaaaga aagagcagat tttggtcgga tttgccgccg 1556161 aaacacaaga cattgaacac tatgcacgta aaaagctcgc cgctaaaaac cttgatttga 1556221 ttgtggcaaa tgatgtgaaa gcaaatgggg ccggttttgg tgctgatacg aatatcgtga 1556281 caatcttttt caaagacggg cataaacgcg aactcccgat tatgtctaag ctcgatgttt 1556341 cttttgaaat ccttcaggag atcgcagccc tctcaaaaca aaccggagag cgctcatgaa 1556401 ttttgcagaa gtcatcgttg atgtcagcac caaaaatata gacaggcctt ttgattataa 1556461 aatcccagac catctgaagg gcatgatcaa aacggggatg cgggtcattg ttccgtttgg 1556521 cccccgtaag attcaagggt ttgtgacagc agtcaaagaa gcatctgacc tatcgggaaa 1556581 atctgtcaag gaagtagagg atttattaga tcttacacct gttctgacag aggagcttat 1556641 gattctgtca tcatggctgt cagacaaaac gctgtctttt aaaataacgg cgcttcaagc 1556701 aatgctgcct gccgccttaa aggcgaaata tgaaaaagaa ttaaaaattg cacacggagc 1556761 cgatcttccg ccgcaagtgg aacggctgtt ttctgaaaca aagacgctgc tgtattcaga 1556821 tatacccgat catgagacgc tgaaactgat tcaaaggcat gttcaaaaag gggacattga 1556881 cgtgacgtat aaagtcgcgc aaaaaaccaa taaaaaaatg gtcaggcata ttcaggcaaa 1556941 tgcgagtaaa gaagagcttg ctaagcaggc tgagggattg tcccgccaag cagcaaaaca 1557001 gcaggcgatt cttcactttc tcatctctga gccggaaggt gtgaaaattc ctgcggcgga 1557061 attgtgcaaa aaaacggaca cgagctctgc aaccatcaaa acccttatcc aaaaagggct 1557121 tttgaaggaa agctatgaag aggtttacag agatccctat caggacaaaa tgttcaaaaa 1557181 aacagagccc ctgccgctga cagacgaaca gagggctgcc ttcgagccca tacgcgagac 1557241 attggacagc gatgagcata aagtgttcct ccttcacggc gtgacaggaa gcggaaaaac 1557301 cgaaatttat ctgcaatcaa ttgaaaaagt actggcgaaa ggaaaagaag ccatcgtcct 1557361 cgtaccggaa atatcgctga cgccgcaaat ggtcaaccgc ttcaagggcc gcttcggctc 1557421 ccaggtggca gtcatgcaca gcggtttatc cacaggagaa aaatatgacg agtggcgtaa 1557481 aatccaccgg aaggaagtac ggcttgtcgt cggtgccaga tccgccattt ttgctccgtt 1557541 tgaaaatctc ggaatgataa tcatcgatga agagcacgag tcttcctata aacaggaaga 1557601 aatgccgcgc tatcatgcga aagaggtggc aatcaagcgg gctgagcatc acagctgccc 1557661 ggttgtatta gggagtgcta cgccgacatt agaatcatat gctagagcgc aaaagggcgt 1557721 atacgagctt ctttcactga agcaccgtgt taaccatcgg gtgatgcccg aggtttcgct 1557781 tgtcgatatg agagaggagc ttagaaacgg caatcgctcg atgttttcag ttgaattgat 1557841 ggaaaagctt gaagaaacga ttgccaaggg tgagcaggcg gtgctgtttt taaataagag 1557901 gggctactct tcctttgtga tgtgcaggga ttgcggctat gtcccgcaat gcccgcactg 1557961 cgacatttcc atgacgtatc atcgttacgg ccaaaggctg aaatgccatt attgcggaca 1558021 tgaagagcct gttccgcaca cttgtcctga atgcgcaagc gagcatatcc gctttttcgg 1558081 aacgggaaca cagcgagtgg aggaagagct gacaaaagtg ctgccaagtg cgagagtgat 1558141 tcggatggat gttgacacga catcacggaa aggcgcccat gaaaaattac tgtcagcttt 1558201 cggagaagga aaagcggata ttcttctcgg aacgcaaatg atcgcgaaag ggcttgattt 1558261 tccgaatgtc acgcttgtcg gagtgttaag tgctgataca acacttcata ttcctgattt 1558321 cagatcggct gaaaaaacat ttcagctgtt aacgcaagtc agcggccggg caggcaggca 1558381 tgaaaagccc ggccatgtca tcattcaaac gtatacaccg tctcattaca gtatccagct 1558441 gacgaaaaca cacgattatg aaacgttcta tcagcatgaa atggcgcaca ggagagagca 1558501 atcctatccg ccatactact atttggctct tgtgactgtt tctcatgagg aagtggcgaa 1558561 agcagcggtt acagctgaaa aaatcgctca ttttttgaaa gcaaactgcg gagctgacac 1558621 gaaaattctc ggaccaagcg cgtcgccgat agccaggatc aaagatagat atcgctatca 1558681 atgcgtgata aaatacaaac aggaaaccca gttatccgct ttattgaaga agatactgga 1558741 acattataaa cgcgaaattg aacaaaaaca tgtaatgatt tcaattgata tgaatcctta 1558801 tatgatgatg taagatctca cgtcttggag ggtaacaaat tggcagtaaa aaaggtcgtc 1558861 acacatcctg cggaggtttt ggaaacacct gcggaaaccg tgactgtttt tgataaaaag 1558921 ctaaaaaaac tgcttgatga tatgtacgac accatgcttg aaatggatgg tgtcggactg 1558981 gcagcgccgc aaatcggcat tttaaaaaga gcggccgtcg tagaaatcgg ggatgacaga 1559041 gggagaattg atctcgttaa tcctgaaatt ttagaaaaaa gcggcgagca aaccggaatt 1559101 gaaggatgct tgagctttcc taacgtctat ggtgatgtca cacgtgccga ttatgtcaaa 1559161 gtgcgtgcgt ttaaccgtca gggaaaaccg ttcattctgg aagcgcgagg ctttttagca 1559221 agagccgtgc agcatgaaat ggaccactta gacggtgtgc tgtttacatc taaaataagt 1559281 aaatactata cagaagatga actagcggat atggaaggat gatttgatga cgagaatcgt 1559341 atttatggga acgccggatt tttcagttcc tgttttaaga accctgatag aggacggata 1559401 tgaagtagtg ggggtcgtca cacagccgga ccgtccgaag ggcagaaaaa aagtactgac 1559461 acctcctccg gtaaaggaag aggcattgcg ccacggcatc ccggttcttc agccggaaaa 1559521 agtcagattg acagaagaaa ttgaaaaagt gctggcatta aagcctgacc tgattgtaac 1559581 ggcggcattc ggacaaattt tgcctaaaga gcttctcgac agtccaaaat acggctgcat 1559641 taacgttcac gcatcccttt tgccggaact gcgcggcggt gctccgatcc attattccat 1559701 tctgcaggga aagaagaaaa ccgggattac cattatgtat atggtagaaa aattggatgc 1559761 gggcgatatg atctcaaaag tggaagtgga cattgaagaa accgacaatg tcggaacact 1559821 gcacgataaa ttaagcgttg ctggcgcgaa gctattgtct gaaacggttc caaacgttat 1559881 tgccggcagc atatcacctg aaaagcagga tgaagagaaa gcgacgtacg cgcctaacat 1559941 taaaagagag caagagctgc tcgactggtc cagaacgggc gaagagcttt acaaccagat 1560001 ccgcggctta aatccatggc ctgttgctta tacgactcta aacggacaaa acttgaaaat 1560061 atgggcgtcg aaaaaaatag cggcaccaac aacagctgag cccggcacag tcgttgcagt 1560121 tgaaaaggaa ggaattatcg ttgccacagg taacgagacg gctctgttat taaccgaact 1560181 ccagccggca ggcaaaaaac gaatgaaagg cgaagacttt gtgcgaggcg ctcatgttga 1560241 agccggtgat gtgttaggag taaacaatga aaaaaactag tgttcgtgac atcgcccttg 1560301 aggcgctgat caaattagaa caaaaccagg catacagcaa cctgctgctg aaatcggtca 1560361 ttaaatcaaa tgaactgagt gatcagaaca gagggctttt gactgaactt gtctatggta 1560421 cattacaaaa taagatcgcg cttgattata tgcttaaacc gtttatcaat aagcctcaaa 1560481 aggtaaagcc gtgggtgatt cagcttcttc gcctatcctt atatcaaatg gagtatttgg 1560541 agaagattcc agacagggca gccattcatg aagcggttga gattgctaaa atccgcggac 1560601 acaaaggcat tgcttcattt gtcaacggcg tgctccgttc tattcagcgc gaaggtgttc 1560661 catcctttga cgcgatcgaa gatcctgtcc gccggctggc gacagaaaca agccatccgg 1560721 aatggcttgt gaaagagtgg gcggatgcgt atggatttga agctgcggaa aagatttgcc 1560781 gcatccatct cattccgccg aaacagacgc tgcgtgtcaa tcaaatgaaa gcagacagag 1560841 ctgagctgct tgaccaaatg gctgctgagg gaatcgaagt tgaaaaaggc gacctcgctg 1560901 aagatgctgt gaagctctta aagggaacaa ttgccggaac tcatttcttc caaaacggcg 1560961 aagtttctat ccaggatgag agctccatgc tcgtcgcccg cgcccttgat cctaagtcag 1561021 atgaaacagt gcttgacgcg tgtgcggcgc ctggcggaaa gtcggctcat atcgcagaat 1561081 taatgaagaa caaggggagc gttacgtcgc ttgatcttca caaacataaa gtgaagctga 1561141 tcaaagaagc ggcagatcgg cttggcctga caatcattca tgcggaaaca atggatgcta 1561201 gaaaagcggg ggaaacgttt gaaaacgaac agtttgaccg aatattggtc gatgccccgt 1561261 gctcaggttt cggtgttatc agaagaaagc cggacatgaa atacacgaaa aaacctgacg 1561321 acagcgcccg tctagctgaa atccagctgt cgatcttgag ggaaatcgca ccattagtaa 1561381 aaaaaggtgg cactcttgtc tacagtacgt gtacaatgga ccggacagaa aatgatgaag 1561441 taatacatgc gtttatacaa gaacatcctg attttgaacc cgatttgtct cttgaaaagc 1561501 ggctgcctga aaaggtgaga ccctttgttc gggatggaag gcttcaaatc cttcctcatt 1561561 atttcggaac agatggtttc tttatttgca gcatgagaaa gaagggataa gcaatggcag 1561621 aacttaataa aacaaaagta agaaaagaat tgcggacaga gcgtccgtct atttattctt 1561681 ttgaattaga tgaaatcaaa caatggctga cagacaatgg agagaaaccg ttccgtgcag 1561741 cccagatctt tgaatggcta tatgaaaaac gcgtatcttc ttttgaagat atgacaaacc 1561801 tctcaaagga tctgcgtgag aaattaaaca ctcgctttgt gttaacaacg ctgaaaacgg 1561861 ctgttaaaca aacctctcaa gacggtacga tgaagttttt gtttgagctt catgacggtt 1561921 ataccatcga aaccgtttta atgagacacg agtatggcaa ttctgtatgt gtaacgacac 1561981 aagtcggctg ccgtattggc tgcacattct gcgcgtcaac gcttggaggc ttaaaacgaa 1562041 accttgaagc aggggaaatt gtcgctcaag tagtcaaagt gcaaaaagct cttgatgaaa 1562101 cggatgaacg cgtcagctct gtcgtgatca tgggaatcgg cgaacctttt gataacttta 1562161 acgaaatgct cgctttcttg aaaatcatta accatgacaa gggcctgaat atcggtgctc 1562221 gccatattac ggtctctacg agtggaatca tcccgaaaat ttacgaattt gctgatcagc 1562281 aaatgcagat taactttgca atttctctgc acgcgccgaa cacagaaatc agaagccgtt 1562341 tgatgccgat taacagagca tataaactgc ctgatctaat ggaagccgtt aaatattata 1562401 ttaataaaac aggacgccgt atcagctttg aatacgggct gttcggaggc gtaaacgacc 1562461 aggtggaaca cgccgaagag cttgccgact tgctggaagg agtcaaatgc cacgtgaact 1562521 tgattccggt aaactacgtg cctgaacggg actatgtgcg cacaccgcgt gatcagattt 1562581 ttgcttttga aaaaacgctg aaatcccgcg gagtaaatgt cacaatccga agagagcaag 1562641 gacatgacat tgacgcagcc tgcggtcagc ttcgcgcgaa ggagcgtcaa gacgagacga 1562701 ggtgatgagg gttgttaaca gccttaaaaa cagatacagg aaaaatccgc cagcataatg 1562761 aagatgatgc ggggatattc aaggggaaag atgaatttat attagcggtt gtcgctgatg 1562821 gcatgggcgg ccatcttgct ggagatgttg cgagcaagat ggctgtgaaa gccatggggg 1562881 agaaatggaa tgaagcagag acgattccaa ctgcgccctc ggaatgtgaa aaatggctca 1562941 ttgaacagat tctatcggta aacagcaaaa tatacgatca cgctcaagcc cacgaagaat 1563001 gccaaggcat ggggacgacg attgtatgtg cactttttac ggggaaaacg gtttctgttg 1563061 cccatatcgg agacagcaga tgctatttgc ttcaggacga tgatttcgtt caagtgacag 1563121 aagaccattc gcttgtaaat gaactggttc gcactggaga gatttccaga gaagacgctg 1563181 aacatcatcc gcgaaaaaat gtgttgacga aggcgcttgg aacagaccag ttagtcagta 1563241 ttgacacccg ttcctttgat atagaacccg gagacaaact gcttctatgt tctgacggac 1563301 tgacaaataa agtggaaggc actgagttaa aagacatcct gcaaagcgat tcagctcctc 1563361 aggaaaaagt aaacctgctt gtggacaaag ccaatcagaa tggcggagaa gacaacatta 1563421 cagcagtttt gcttgagctt gctttacaag ttgaagaggg tgaagatcag tgctaatcgg 1563481 caagcggatc agcgggcgtt accaaattct ccgcgtcata ggcggcgggg gaatggccaa 1563541 cgtgtattta gctgaggata tcattctaga ccgtgaagtc gcaattaaaa tcctgcggtt 1563601 tgactatgca aatgacaatg aatttatcag acgtttccgc agagaagccc aatccgcatc 1563661 aagcctcgat cacccgaata ttgtcagcat ttatgatttg ggcgaggaag atgatattta 1563721 ttatattgtc atggaatacg ttgaaggcat gacgcttaaa gaatacataa cagcaaatgg 1563781 gccgcttcac cctaaagaag cgctgaacat catggagcaa attgtctcag ccatcgctca 1563841 tgcccatcaa aaccagattg ttcacagaga catcaagccg cataacattt tgattgatca 1563901 tatgggaaat atcaaagtaa cggattttgg aattgcgacg gcactaagtt cgaccacaat 1563961 cacccatacc aattcagttc tgggctcggt ccattactta tcacctgaac aggcccgggg 1564021 cggcttagcc acaaaaaaat cggatattta tgcgcttgga atcgttctat ttgagctttt 1564081 aaccggccgt attccgtttg atggagagtc agcagtcagc atcgccttga agcatcttca 1564141 agcggaaact ccttcggcaa aaaggtggaa tccatcggtc ccccaaagcg ttgaaaacat 1564201 catactcaag gcaactgcca aagatccttt tcatcgctac gaaacggctg aagacatgga 1564261 agcagacata aaaacagctt ttgatgccga cagactcaat gaaaagagat ttacgattca 1564321 agaagatgaa gaaatgacaa aagcgatacc tatcattaaa gatgaagaac ttgctaaagc 1564381 tgctggcgaa aaagaagctg aagtgacaac cgcacaagaa aacaaaacaa agaagaacgg 1564441 caaaagaaaa aagtggccgt gggttttgct cacgatatgc ctcgttttta tcacagctgg 1564501 aattcttgct gtcactgttt ttccgtcgct tttcatgcct aaggatgtca aaatacctga 1564561 tgtctccgga atggaatacg aaaaagccgc agggctcttg gaaaaagaag gtttacaggt 1564621 tgattccgag gtgttggaaa tctcagatga aaaaattgaa gagggcctga tggtaaaaac 1564681 ggatcctaaa gcggatacca cagtcaaaga aggcgccacg gtcacccttt ataagagcac 1564741 cggaaaagca aaaacggaga tcggtgatgt gacaggccaa acggtcgacc aagcaaaaaa 1564801 agcgttgaag gaccaagggt ttaatcatgt aacagtaaat gaagtgaatg acgagaaaaa 1564861 tgcgggcact gtcattgacc aaaatccttc agcagggact gagctggtcc cgagtgaaga 1564921 tcaagtcaaa cttacagtca gtatcggacc cgaagacatt acgcttagag acttgaaaac 1564981 ctacagtaaa gaagcagcgt ctggatatct ggaagacaac ggattgaagc ttgtagaaaa 1565041 agaagcatac tcagatgatg ttccagaagg acaggttgtc aaacaaaaac cagcagcagg 1565101 tacggcagta aagccgggaa acgaagttga agtgacattc tctctcggac cagagaaaaa 1565161 acctgcgaaa acagtgaaag aaaaggtcaa gatcccctac gaaccagaaa atgaagggga 1565221 cgagcttcaa gtgcaaatcg cggttgacga tgcggatcac agcatctctg acacttacga 1565281 agaatttaag ataaaagagc cgactgaacg aacgatcgaa ctaaagattg aaccaggcca 1565341 aaaagggtac tatcaagtaa tggtaaacaa taaagttgtc agctacaaaa ccattgagta 1565401 tccgaaagat gaataacaag gagggaaaat atgcctgagg gcaaaattat taaggcgcta 1565461 agcggctttt actatgtact ggatgaatca gaggattcag ataaagtaat acaatgcaga 1565521 ggaagaggca ttttcagaaa aaacaaaatt acccctcttg tcggtgatta cgttgtgtat 1565581 caagctgaaa atgacaaaga aggatatcta atggaaatta aagaaagaac caacgagctt 1565641 atcaggccgc caatttgcaa cgttgatcaa gcggtccttg ttttctcagc ggttcagcct 1565701 tctttcagca cggcattgct cgaccgcttc ctggttctcg ttgaggccaa tgatattcag 1565761 ccgattatat gcattactaa aatggatctg attgaagatc aagatacaga agatacgata 1565821 caagcctatg cagaagacta tcggaatatt ggttatgacg tataccttac ctcctctaag 1565881 gaccaagata gtttagcgga catcatcccg cattttcagg ataaaacaac ggtatttgcc 1565941 ggtcagtccg gtgttgggaa atcctcgctt ctcaacgcga tcagtccgga gctcggatta 1566001 agaacaaacg agatttccga gcatttgggc cgcgggaaac acacaacccg ccacgtggag 1566061 ctgattcaca cgtccggagg tttggttgca gatacaccgg gattcagctc gcttgaattt 1566121 acagacattg aggaagaaga gctgggctat accttccctg atatcagaga aaaaagctct 1566181 tcatgcaaat ttagaggctg tttacatctg aaagagccga aatgtgcggt gaaacaagct 1566241 gttgaagacg gggaattaaa gcagtatcgc tatgaccatt atgttgaatt tatgacggag 1566301 attaaagaca gaaagccgag gtattagcat aatgataaag gttgcaccat ctattctttc 1566361 cgctgatttt gccgctttag gcaatgagat taaagatgta gaaaaaggcg gagccgattg 1566421 tattcatatt gatgttatgg acggccattt tgtcccgaat atcacaatcg gtccgctgat 1566481 tgtagaagcg gtccggccgg taacggatct gccgcttgat gtccatttaa tgatagaaga 1566541 gccggatcgt tatatcccgg cttttgcgaa agcaggcgca gatatcctgt ctgtgcatgc 1566601 tgaggcatgt ccgcacctgc accgtaccat ccagctcatt aaagagcaag gagtgaaggc 1566661 cggagtagtt ctaaacccgc atacccctgt acaagtcatc gaacatgttt tcgacgatct 1566721 tgatcttgtt cttttaatga cggtgaaccc gggcttcggc gggcagaaat ttattcattc 1566781 agtccttcct aaaataaaag aggttaagcg aatggcggat gaaaaaggaa aaaaagatct 1566841 gttaattgaa gtagacggcg gcgtcaacaa agaaaccgct ccgctcgtca ttgaagcggg 1566901 cgcaaattta ctcgttgccg gttcagctgt ttatggccag tctgaccgca aaaaagcaat 1566961 ttctgaaatc agaggaagta aataagcagc tttagaaaag agctgggcat acaatagcct 1567021 aagctctttt tcctgtatgc agagaaagga atcagagatg aaaacaatta atatcgttgc 1567081 gggaggcccg aaaaatctca ttcccgatct aaccggctat acggatgaac acacgctttg 1567141 gatcggtgtt gacaaaggca ccgtcactct cttagatgcc gggatcattc ctgttgaagc 1567201 cttcggagat tttgacagca taacggagca agaacgccgg cgaatagaaa aagccgctcc 1567261 cgcccttcat gtgtatcaag cagaaaaaga tcaaacagat ttagacctcg cccttgattg 1567321 ggcgctggaa aagcagccgg atattattca gattttcggc attacaggcg gcagagctga 1567381 tcatttttta ggaaacattc agcttctgta taaaggtgta aaaacgaaca taaaaattag 1567441 gctgatagac aaacaaaatc atattcaaat gttccctcct ggtgaatatg atattgagaa 1567501 ggatgaaaat aagcgatata tctccttcat accgttttcc gaagacatac atgagctgac 1567561 cctgaccggt tttaaatatc ctctaaataa ttgtcatatt acgctcggtt caacactatg 1567621 tattagtaac gaactcattc attcacgagg tactttttcg tttgcaaaag gcatattaat 1567681 aatgataaga agcacggatt aagcatgtgc tttcattcaa ttgctgaaaa caatgaacaa 1567741 ggcggttacg ggacgttata ggaggggaca aaaatgaaat tttacaccat taaattgccg 1567801 aagtttttag gaggaattgt ccgggcgatg ctgggctcat ttagaaaaga ttaatgccca 1567861 ggggttcaaa gccctctttc accacataaa aacgcctgcc acatatcggg gcaggcgttc 1567921 attttgttat acacgctcaa ctttaccgga tttcaaagct cgagcagata catatacttt 1567981 tttaggtttt ccgttcacaa ggatacgaac cttttgaaga ttcgcgcccc aagtgcgctt 1568041 agaagcgttc attgcgtgag aacggttatt cccagctgtt gtttttttac ctgtgataac 1568101 gcatttacgt gccatttgtt tccctcctca cttgcacaaa acatctactt tttaacattc 1568161 atataatctt agatgctttc gatatggata ctttaaataa tttaccacag ctaaaaaacg 1568221 tttgcaacta ttgtttcatc atctttcaag aaaattcact tgacatcttg cggaaacagc 1568281 agcgctatag tatatgtaga ggtacggcca gcgattattg cctggtcttt tcataatgga 1568341 aaccatatag tagaatagct gtaactctat gcattcgaag gaggaactag tgtgtccatt 1568401 gaattaagaa cgaagtacgg acagattgat atatctaatg aagtcatcgc gatggttgca 1568461 ggaggcgcgg cggttgactg ttacggcatt gtcggcatgg cctctaaaaa ccagattaaa 1568521 gacggactga ctgaaatcct tcggaaagag aatttcagca ggggtgtcca agttcgccaa 1568581 gaaggagaac agatacatat cgacatgtat atcattgtca gctacggcac gaaaatttct 1568641 gaagtggcac ataatgtcca aacaaaagta aagtacacag taaatcaaac catcggactg 1568701 gcagtggatt ctgtcaatat ttatgtccaa ggcgtacgag tgacgaaccc gtagttagga 1568761 ggagtaggat tgtctatcag aacattagac ggcagaacct ttgccgagat gattcttgcg 1568821 ggagcgcaga atctgtctca aaacgccagt gcagttgatg cactgaacgt gttcccggtg 1568881 ccggacggtg atacgggaac aaatatgaac ctgtcgatga cttccggagc aagagaagtt 1568941 gaacaaatgg atacggatga tatcgggaag gtgggctccg cgttatctaa agggctgctc 1569001 atgggagcac gcggaaattc aggagttatc ctatcccaat tgttccgcgg atttagcaaa 1569061 aacattgaaa cgaaaaaaga aattaatgca cttgagtttg ccgctgcgct gcaagcaggt 1569121 gtagacatgg cgtataaagc tgtcatgaaa cctgtagagg gcaccatttt aacagttgca 1569181 aaagacgctg caaaaaaagc aatgatctta gcagaaaaag aaaccgatat cactgcgctg 1569241 atgactgcag tgacagaaga agcagaggcg tctttaaacc gcacccctga attgctacct 1569301 gtcctaaagg aagtaggagt tgtcgatagc gggggcaaag gcctgctctg tgtgtatgaa 1569361 ggtttccttg cttcattaaa aggtgaaact gtacctcaga aagcagttct tccgtcactt 1569421 gacgacatgg tcagcgcaga gcatcacaag agcgcgcaaa gcatgatgaa taccgaagat 1569481 attgaatttg gattctgtac cgaagtgatg gttaggcttg atcagacaaa aagagagttc 1569541 gacgaaggca cgttcaggca agacctcagc cagttcggag attctctgct tgtgattgcg 1569601 gatgaatcgc tggcgaaggt tcatattcat gctgaagagc cgggaaacgt gttaaactac 1569661 gcccagcatt acggtgaatt gatcaaaata aaaatagaaa atatgagaga acagcatacc 1569721 tctatcatca gtcaagaaag caaacctgca gacaacgaaa caccgccggc aaaacagccg 1569781 tatggcattg tgactgtagc gatgggagaa ggaattgcag acctatttaa aagcattggc 1569841 gcttctgttg tgattgaagg cggccagacc atgaacccaa gcactgagga tattgttgat 1569901 gccgtgaagt ctgtaaatgc agatacggta tttatcctgc ctaacaactc caacattatc 1569961 atggctgcta accaagcggc cagcgtagtg gatgaacagg tttttgtcat tcctgctaaa 1570021 acggttccgc aagggatgtc agctctgctg gcttttaacc cggatcaaga agctgaagcg 1570081 aacgaggcca atatgctaag cgccattcag caagtaaaaa gcggacaggt gacgttctca 1570141 gtcagagata ctcatattga cggtaaagac attaaaaaag gcgactttat gggcattctg 1570201 aatggaacga ttatcggcac ttctgaaaat cagctgtcag ccgcgaaaat gctgctgtca 1570261 gaaatgatcg gagaagatga tgaaatcgtg accattctat atggtgagga tgcgtctcag 1570321 gaagaagctg agcagcttga agcgtttctc agtgaaaagt acgaggagat tgaggttgag 1570381 atccacaatg ggaaacagcc tctgtattcg tatatagttt cagcagaata gaagggcaat 1570441 ttgcccttct attcttatgt ctgcttttaa gtgcggcagc gctgtaacgc gcccgcttgc 1570501 cattttatat ctgatcaatt agtctagaag caaagcgcta ataagctctg gttcataagg 1570561 aggaatagca tgaaatacag aagcgttttt gatattatcg gcccggttat gatcggtccg 1570621 tccagctctc atacagcggg agctgctaga atcgggagag tggccagaag tttatttggc 1570681 agagagcctg agcgcatcat tgtatctttt tacggctcgt ttgcggaaac gtataagggc 1570741 cacggcacag atgtcgcgat tatcggcgga ttgcttgatt ttgatacatt cgatgaacgg 1570801 attaaaaccg ctatacaaat tgcagaagct aaaggaattg atatagagtt tcgggtagaa 1570861 gacgcagtcc cggtccaccc gaacacagca aaaatcacca tttctgatga aaagggtgag 1570921 ctggaactga cgggtatttc gattggcgga ggaaagattg aaatcacaga attgaatggt 1570981 tttgagctcc ggctgtcagg aaatcatccg gccatattag ttgttcataa tgacaagttt 1571041 ggcacaattg ccggtgttgc caatgttctg gcgaaatttt caatcaacgt aggacatatg 1571101 gaagtagccc ggaaagatat cggccagctt gcgctgatga caatagaggt cgatcaaaat 1571161 attgacgacc acattctcga cgagctgtcg aagctgccga atattattca agtgacaaag 1571221 attgctgact agcgaaaagg gtcaggagga gccagttatg tttcgtaatg taaaagaatt 1571281 aattgagatt actaaagaaa aacaaatatt gatctctgat gtgatgatag ctcaagagat 1571341 ggaagtaaca gaaaaaacaa aagaggacat ttttcagcag atggatcata acctgtctgt 1571401 tatggaagcg gcggttcaga aaggactcga gggagttacg agccaaacgg gcttaacagg 1571461 cggagatgcc gttaaattgc aggcctatat tcgatcagga aaaagcctgt ctggcccgct 1571521 gattttagat gctgtatcga aagccgttgc aacaaatgaa gtaaatgcag ccatgggaac 1571581 catctgtgcg acaccgactg caggttctgc cggtgtggtg cccggtacgt tatttgctgt 1571641 aaaagaaaag ctgaatccaa caagagaaca aatgatccgc tttttgttta cagccggggc 1571701 tttcggattt gtcgtggcca ataacgcaag catttccggc gccgccggag gatgtcaggc 1571761 agaggttgga tcagcttcag gcatggcggc tgcggctatt gttgaaatgg caggaggaac 1571821 acccgaacaa agcgcggaag ccatggccat tacattaaaa aatatgctag gcctcgtgtg 1571881 cgaccctgtt gcagggcttg ttgaggtgcc ttgcgtgaaa cggaatgcga tgggcgcgtc 1571941 aaatgcgatg attgctgctg atatggcatt ggcgggcatt acaagccgta ttccatgtga 1572001 tgaggttatc gatgccatgt ataaaatagg ccaaacgatg ccaactgcac ttagagaaac 1572061 aggccagggc ggtttagcgg caacaccgac aggaagagaa ttagagaaaa aaattttcgg 1572121 aggagcgcta ggttcacgtg aaacaacatc agcaaactag tatagctaac attaagggta 1572181 ttgggccgga aacagaaaaa acattgaatg aactcggtat ttatgacatt tctgatcttc 1572241 tgaattattt cccttatcgc tatgatgact acgagctgag ggatttagaa gaagtaaagc 1572301 atgatgaaag agtcacagtc gaagggaagg ttcattcaga gccttctctt acctattacg 1572361 gaaaaaaacg aaacaggctg acattcaggc ttctggtcgg ccactattta atcacagccg 1572421 tatgttttaa ccggccttat ttgaagaaga agctttcgct cggctctgtg gtgacggttt 1572481 caggtaaatg ggacaagcac cgccaaacca tctctgttca ggagttgaaa aacgggccgc 1572541 atcaagaaga caaaagcatt gaaccagtgt attctgtgaa agaaaatgtt accgtcaaaa 1572601 tgatgaggcg ctttattcag caggcgctga cccaatatgc agactcactt cctgatcctc 1572661 ttccggaaaa gctaagaaaa agctataaac tgcctgacta ttatcaagcg ttaaaagcaa 1572721 tgcaccagcc tgaaacaagg gaagcattaa agcttgccag acggcggttt gtttatgaag 1572781 aatttttgtt gtttcagttg aaaatgcagg cgttccgaaa ggcggaaaga gagcagacac 1572841 aagggatacg gcagcgtttt tcaaacgaag aactcatgag atttatcaaa agcctcccgt 1572901 ttcccctcac aaacgcccag tcacgcgttc ttcgcgaaat aacagcagac atgtcttctc 1572961 catacagaat gaaccgtctt cttcaagggg acgttggatc aggaaaaacg gcagtcgccg 1573021 ccattgcact gtatgccgcg atcctatccg gataccaagg agcgctcatg gtgccgacag 1573081 aaattctggc cgagcagcat gctgattcgc tcgtttcgct atttgaaaaa tgggacgtca 1573141 gcgttgctct tttgacaagc tctgttaaag gaaagcggcg aaaagaactg cttgagcgtc 1573201 ttgcggcggg tgagattgat attcttgtag gaacccatgc tttaatccaa gacgaggtgg 1573261 agtttaaggc gttgagtctc gttattactg atgaacagca cagatttgga gttgagcagc 1573321 gcaaaaagct tcggaacaaa gggcaggatc ccgatgttct ctttatgaca gccactccaa 1573381 tcccaagaac attagcgatc acagtattcg gtgaaatgga tgtatctgtc attgatgaga 1573441 tgccggctgg acgaaagcga attgaaacct attgggtaaa acatgacatg cttgatcgta 1573501 ttttggcatt tgtcgaaaaa gaattaaagc aaggcaggca ggcttatatc atctgtccgc 1573561 tgattgaaga atcagataag cttgatgtgc aaaacgccat tgacgtgtac aatatgcttt 1573621 ctgatatttt tcggggaaaa tggaatgtcg gccttatgca tggaaagctg cattccgatg 1573681 aaaaagatca ggtcatgaga gaattcagcg caaatcactg tcaaattctc gtatcaacca 1573741 ctgttgtgga ggttggcgta aatgttccga atgcaacaat tatggtgatt tatgacgccg 1573801 accgtttcgg actatcacag cttcaccagc tgcgcggccg tgttggacgg ggtgagcatc 1573861 aatctttctg tattctgatg gctgatccaa aatcagaaac agggaaagaa cggatgagga 1573921 tcatgtcgga gaccaatgac ggtttcgagc tgtctgaaaa ggatctggaa ctgagaggtc 1573981 ccggtgattt cttcgggaaa aaacaaagcg gaatgccgga atttaaagtg gcggacatgg 1574041 ttcatgatta cagagcgctt gaaacggcaa ggcaggatgc tgcgaatctt gtggcttctg 1574101 acgcgttctg gaaggagccg gaatacgctg tgttaagaga tgaattgctg aagagcggag 1574161 taatggacgg ggaaaaatta agctgagtat cagaagtttt tggtgttcag ccagaaacaa 1574221 tcgttgcatt ccaatctatg aaattatata ctactattag tacctagtct taattgtccg 1574281 gatggtgttt agatatgaga agaaataaga gagaacgcca ggaattactt cagcagacga 1574341 ttcaagcaac cccctttatt acagatgaag aactagcggg taaattcggg gtgagcatcc 1574401 agacgatacg tttggaccgc ttagagcttt ccatacctga actgagagaa agaattaaga 1574461 acgtggcaga gaaaacactt gaggacgaag tgaagtccct gtcacttgat gaagttatcg 1574521 gagaaattat tgaccttgag ctggatgatc aggcgatatc cattttagaa ataaaacagg 1574581 agcacgtgtt cagccggaat cagattgcga gaggacacca tttatttgca caggcgaatt 1574641 ctttggccgt tgcagtcatt gatgacgagc tggcgctgac tgcaagtgca gacatccgct 1574701 ttacaagaca ggtaaagcag ggtgaacgtg tcgtagcaaa agcgaaagtg acggctgtcg 1574761 aaaaagaaaa aggaagaacg gttgtcgaag tgaacagcta cgttggcgaa gaaattgttt 1574821 tttctggacg ctttgacatg tatcgttcaa aacattcata aaggtggagc atgcatgaga 1574881 atagctgtag atgcaatggg aggagaccac gctcccaaag ctgttattga cggagttata 1574941 aaaggtatag aggcatttga tgatctccat atcacacttg tcggtgacaa aacaacgata 1575001 gaatcacatt taacaactac atcagatcgc atcacggtgc tgcacgcaga tgaagtgatt 1575061 gagcctacgg atgaaccggt ccgtgccgtg cgaagaaaaa agaactcatc tatggttctt 1575121 atggcgcagg aggttgcgga aaacagagct gacgcctgca tttcagcggg aaataccggt 1575181 gcattaatga cagccggtct ctttattgtc gggagaatta aaggaattga ccgtccggcg 1575241 cttgctccga cacttccgac tgtttcggga gacggatttc ttctccttga tgtcggcgcc 1575301 aatgtcgatg ccaaaccgga gcacctcgtt caatatgcca tcatgggttc tgtttattct 1575361 cagcaagtgc gcggtgtcac ttcaccgaga gtcggacttt taaatgtcgg aacagaagat 1575421 aaaaaaggaa acgaactgac gaagcagacg tttcaaattt taaaagaaac agcaaacatc 1575481 aattttatcg gaaacgtgga agcgcgagac cttttagatg atgtggcgga tgttgtagta 1575541 acagacggct ttaccgggaa tgttacactc aaaacgctgg aaggctctgc gttgtcaatt 1575601 tttaaaatga tgagagacgt aatgacgtct actttgacat ccaagcttgc agcagctgtg 1575661 ctgaaaccaa aattgaaaga aatgaaaatg aaaatggagt attcgaatta tggcggagca 1575721 agtctttttg gcttaaaagc gcctgtgatc aaggcgcacg gctcttcaga ttcaaatgct 1575781 gtattccatg cgattcggca agcaagagag atggtcagcc aaaatgtggc tgcgctcatt 1575841 caggaagaag tgaaagaaga aaaaacagat gagtagtctg gaggttttta catcatgagt 1575901 aagattgcat ttttattccc gggtcaggga tcacaattta tcggcatggg aaaagagctt 1575961 tatgagcagg tgcctgctgc aaagcgtctg tttgatgaag ccgatgaaac gttggaaaca 1576021 aaactcagct cgcttatttt tgagggggat gctgaagaat taacacttac atacaatgcg 1576081 cagcctgctt tgcttacgac aagcatcgct gttcttgaga aatttaaaga atctggcatt 1576141 acacctgatt tcacagcagg acacagcctt ggtgaatatt ctgcactggt tgcggctggc 1576201 gctctgtctt tcaaagatgc tgtttatact gtcagaaagc gcggagagtt tatgaatgaa 1576261 gcggtgccgg ctggcgaagg agcaatggct gcgattctcg gcatggatgc tgaagcatta 1576321 aagcaagtaa ccgataaagt cacagaggaa ggcaaccttg tacagcttgc gaatctcaac 1576381 tgtcctggcc aaatcgtcat ttccggaaca gctaaagggg ttgagcttgc atctgaactg 1576441 gcaaaagaga acggcgcaaa acgcgcaatt ccgcttgaag taagcggtcc gttccattct 1576501 gaactgatga aaccggctgc tgaaaagctg aaagaggtat tggacgcctg tgacataaaa 1576561 gacgctgacg ttccggtcat ctcaaatgtt tctgctgacg tgatgactga aaaagcagat 1576621 atcaaagaaa aacttattga gcagctttac tctccggttc gttttgagga aagcattaac 1576681 aagctgatcg cagagggtgt tacgactttt attgaaatcg gtcccggaaa agtgctttca 1576741 ggccttgtga aaaaagtgaa tagacggtta aaaacaattg ctgtatcaga tccggaaacg 1576801 atcgagctgg caattcaaac gcttaaggag gagaatgata atgcttaatg ataaaacggc 1576861 tattgtcact ggcgcatccc gcggaatcgg ccgctcaatc gcccttgatc tggcaaaaag 1576921 cggagcaaat gttgtcgtga actactccgg caatgaagcg aaagcaaatg aagtggtaga 1576981 tgaaatcaaa tcaatgggca gaaaagcaat tgctgtaaaa gcggatgtat caaatcccga 1577041 agatgtacaa aacatgataa aagaaacatt gtctgttttt tctacgattg acattctggt 1577101 taataatgcg ggaattacaa gagacaatct catcatgaga atgaaagaag acgaatggga 1577161 tgacgtcatt aacattaacc tgaagggtgt tttcaactgc acaaaagctg ttacaagaca 1577221 aatgatgaaa cagcgttcag gccgcattat taacgtatcg tctatcgtcg gcgtcagcgg 1577281 aaaccctgga caagccaact acgtggctgc aaaagccggc gtcatcggtt taaccaaatc 1577341 ttctgctaaa gagctcgcca gccgaaatat tacggtaaac gcaatagcgc caggatttat 1577401 ctcaactgat atgacagata aacttgcaaa agacgttcaa gacgaaatgc tgaaacaaat 1577461 tccgctcgcg cgctttggtg aacctagcga tgtcagcagt gttgtcacgt tcctagcttc 1577521 agagggagct cgttatatga caggccaaac gcttcatatt gacggcggaa tggtgatgta 1577581 agttttttct cgaaaatttc atcgtagttt ctctagtttt ttaaaaacga atccactata 1577641 atacttgagg ggaggtgaat tgctatggca gacacattag agcgtgtaac gaaaatcatc 1577701 gtagatcgcc ttggcgttga tgaagcagac gtcaaacttg aagcttcttt caaggaagac 1577761 ttaggtgctg attccctaga tgtagttgag cttgttatgg aacttgaaga cgagtttgat 1577821 atggagattt ctgacgaaga tgctgaaaag attgcaacag tcggcgacgc tgtgaactac 1577881 atacaaaacc agcaataagc tgatgctaaa agtcccgccg aaacgcgggg ctttagccct 1577941 ttattcgtgc agttattaca gcatgccgct tttacgcgcg ctgtatccgg tttagtcaga 1578001 gaagcgcggt gaacctgatg tgcctatgga ggttactatg tcaaaacact cacattataa 1578061 agataaaaaa aagttctata aaaaagtaga acaatttaaa gagtttcaag aacggatttc 1578121 ggttcacttt caaaatgaaa agcttttgta tcaagcattt acacattcat cttatgtgaa 1578181 tgagcatcgg aaaaagccgt atgaagataa tgaaaggctt gaatttttag gtgacgctgt 1578241 tttggaactg acgatctcca gattcttatt tgccaaatac ccggctatga gtgaaggaga 1578301 tttgacgaaa ttgagagccg caattgtttg cgaaccgtct ctcgtttcat tggctcacga 1578361 gctgtcattc ggcgatcttg tcctgttggg taaaggcgag gaaatgacag gcggaagaaa 1578421 gcgtcctgct ctattggcgg atgtttttga ggcatttatc ggagccttgt accttgacca 1578481 aggattagag ccggtcgaaa gtttcttaaa agtttatgtg ttccctaaaa ttaacgatgg 1578541 tgctttttct catgtgatgg atttcaaaag ccagctgcag gaatacgtgc agcgggacgg 1578601 caaaggctct ctggagtata aaatctccaa cgaaaaagga cctgcgcaca accgtgaatt 1578661 tgaagccatc gtatctctaa aaggtgaacc actcggagtc ggaaacggcc gttcaaagaa 1578721 agaagccgaa cagcacgctg ctcaggaagc tttagctaaa ttgcaaaaac accatacgaa 1578781 acaataaaat cccccttatg actcaggggg atttcagtat gtatgccgtc ttatttgacc 1578841 aatgtttatg atagaattga aatacttatt acataaggag gatcgctatg ttcctcaaac 1578901 gtttagacgt tataggattt aaatcatttg cagaacggat ttccgtagac ttcgttaaag 1578961 gcgtgacagc agttgtcggg ccgaacggaa gcggaaaaag caacatcacg gatgccattc 1579021 gctgggttct cggcgaacaa tcggcacgct ctcttcgcgg cggaaaaatg gaagacatca 1579081 tttttgctgg gagtgattca agaaagcgat taaatctagc tgaagttacg cttactcttg 1579141 ataatgatga tcatttcttg ccaattgact tccacgaggt gagtgtcaca agacgtgtgt 1579201 acagatcagg tgagagtgag tttctgatta acaatcagcc atgccgcttg aaagatatta 1579261 ttgatttatt tatggactct gggcttggta aagaagcatt ttctattatc agccaaggga 1579321 aagtggaaga gatcctgagc agcaaagcgg aggatcgccg cagtatcttt gaagaagcgg 1579381 ccggggtgct taaatataaa acgagaaaga aaaaagcaga aaataaactg tttgagacac 1579441 aggacaatct aaatcgggta gaagatatat tacatgagct tgaaggacag gttgaacctc 1579501 ttaaaattca agcttcaata gcgaaagact accttgagaa aaagaaagag ctggagcatg 1579561 ttgaaattgc gctgactgcc tatgatatcg aagagctgca tggtaaatgg tcgactctta 1579621 aagagaaagt gcagatggca aaagaagaag agcttgctga atcgtctgct atttctgcga 1579681 aagaagcaaa gattgaggat acaagggaca aaatacaagc gcttgatgag tcagtagatg 1579741 agctccagca agttttactg gtaactagtg aagagctgga aaagcttgaa ggccgtaaag 1579801 aagtcctgaa agaacgaaag aaaaacgctg tgcaaaacca agaacagctt gaagaagcca 1579861 tcgttcagtt ccagcaaaaa gaaacggttc tgaaagaaga gctttcgaag caggaagctg 1579921 tcttcgaaac gcttcaggct gaggtgaagc agttaagggc gcaagtaaaa gaaaaacagc 1579981 aggctctcag tcttcacaat gaaaatgtcg aagagaaaat cgagcagctg aaaagtgatt 1580041 attttgagct gttaaacagc caggcttcga tacgcaacga actccagctt cttgatgacc 1580101 agatgtccca atccgctgtc acattgcaga gacttgcgga caacaatgaa aagcacctgc 1580161 aggaacggca tgatatttct gcgcgtaaag ccgcatgtga aacggaattt gcccgaattg 1580221 agcaggagat tcacagtcaa gtcggtgcat atcgtgatat gcagacaaaa tatgagcaga 1580281 aaaagcgcca atacgaaaaa aatgaatccg ctctgtatca ggcataccaa tacgttcagc 1580341 aagcgagatc aaaaaaggac atgcttgaga cgatgcaggg agatttctcc ggcttttatc 1580401 aaggtgttaa agaagtgctg aaagcgaaag agcgccttgg cggaattcgc ggagcggttc 1580461 ttgagctgat ttctacagaa cagaagtatg aaacggccat tgaaatagcg ctcggcgctt 1580521 ctgctcaaca cgtcgtgacc gacgatgaac aatctgcccg caaagcgatt caatatttaa 1580581 agcagaattc cttcggccgg gcgacgtttc tgcctctttc tgttattaga gaccgccagc 1580641 ttcaaagccg tgacgcggaa acagccgccc ggcattcatc atttctcggg gttgccagtg 1580701 aacttgtcac atttgatcct gcgtatcgaa gcgtcatcca gaatcttctt ggaaccgttc 1580761 tgatcacaga ggacttaaag ggtgcaaacg agcttgcgaa gcttctcggg caccggtacc 1580821 gcatcgtaac ccttgaggga gatgttgtga accccggtgg ttcaatgacg ggcggcgcgg 1580881 ttaaaaagaa aaataactcc ctccttggaa gaagccggga gctagaagat gtgacgaaac 1580941 ggctcgctga aatggaagag aaaacggcac tgcttgaaca agaggtcaaa acccttaagc 1581001 actccattca ggatatggag aaaaaactgg ctgacttaag agaaaccggg gaaggcttaa 1581061 ggttaaagca gcaggatgtg aaaggccagc tgtacgaact tcaagttgcc gagaaaaata 1581121 tcaataccca tttagagctc tatgatcaag aaaaatctgc tctgtcagaa agcgatgaag 1581181 agagaaaagt gcgcaaacgc aagcttgaag aagagctctc tgccgtatct gaaaagatga 1581241 aacagcttga agaggacata gacagactga caaaacaaaa acaaacgcaa tcctcaacga 1581301 aagagtctct ctccaacgag ctgactgagc tgaagatcgc agcggccaaa aaagagcagg 1581361 cttgcaaggg ggaagaggac aaccttgcca gattaaagaa agagctcact gaaacagagc 1581421 ttgcgttaaa agaagcaaaa gaagacttaa gcttcttaac gtcagagatg tcatctagca 1581481 ccagcggcga agaaaagctg gaagaagcag caaaacataa attgaatgac aaaacgaaaa 1581541 cgatcgaact gattgcatta aggcgcgatc agcgcatcaa gcttcagcat gggcttgata 1581601 cgtatgagcg tgagctgaaa gaaatgaaac gcctgtataa acaaaaaaca acgctcttaa 1581661 aagacgaaga agtcaaactt ggacgaatgg aagtcgagct tgataattta ctccaatact 1581721 tacgggagga atacagcttg tcctttgagg gggcaaaaga gaaatatcag cttgaaactg 1581781 atccagagga agccagaaag cgcgtgaagc tgattaaact cgcaattgaa gagctgggta 1581841 ccgtgaacct cggaagcata gatgagtttg agagggtcaa cgaacggtac aagtttctgt 1581901 cggaacaaaa agaagattta acagaagcga aaaatacctt gttccaagtg attgaagaaa 1581961 tggatgaaga aatgacgaag cgctttaacg acacattcgt ccaaatccgc tcacactttg 1582021 atcaagtttt ccgctcctta ttcggaggag ggcgagctga actgaggctc accgatccta 1582081 acgatctgct tcattcagga gtcgagatta tcgctcagcc gccggggaaa aagctgcaaa 1582141 acttaaacct cctgtcaggc ggagagcgtg cgcttactgc tatagcgctc ttattctcaa 1582201 tcctaaaggt tcgtccagtg ccgttttgcg tccttgacga agtagaggct gcgctcgacg 1582261 aagcgaatgt gttccgattt gcgcagtatt taaaaaaata cagcagcgat actcagttta 1582321 ttgtgattac ccacagaaaa ggaacgatgg aggaagcgga tgtgctttat ggcgtaacca 1582381 tgcaggaatc cggtgtttcc aaggtaattt cagttaagct ggaagaaaca aaagaattcg 1582441 ttcagtaacg aggaaagagg ttaaaagatg agctttttta aaaaattaaa agagaaaatc 1582501 acaaaacaga cagattccgt atctgaaaag tttaaggatg gccttgaaaa aacaagaaac 1582561 tcctttcaaa acaaagtgaa tgatcttgta tcccgttacc gtaaagtgga tgaggatttc 1582621 ttcgaagagc ttgaagaggt tcttatcagc gcggatgtcg gttttacaac cgttatggaa 1582681 ttaatagatg agctgaaaaa agaagtcaaa cgcagaaata ttcaagatcc aaaggaagtc 1582741 cagtcagtga tttctgagaa actggtcgag atttataaca gcggagatga gcaaatttca 1582801 gaactgaaca tccaggatgg gcgtttaaac gtaatccttc tggtaggtgt aaacggcgtc 1582861 gggaaaacaa caacgatcgg aaagcttgct cataaaatga aacaagaagg aaaatctgtt 1582921 gtacttgccg ccggagacac ttttagagcg ggagccattg aacagctgga agtatgggga 1582981 gagcgtacag gagtgcctgt cattaagcag acggcaggaa gcgatccggc ggctgtcatc 1583041 tacgatgctg ttcatgctgc gaaagcaaga aatgccgatg tattaatttg tgatacggca 1583101 gggcgtctcc aaaacaaagt aaatctcatg aaagagcttg aaaaagtaaa acgtgttatc 1583161 gaaagagaag ttcctgaagc tccgcatgag gtgctgcttg cccttgatgc cacgaccggc 1583221 caaaatgcaa tggctcaggc aaaagaattc tctaaagcaa caaatgttac cggcattgct 1583281 ttaacgaagc ttgacggtac ggcaaaaggc ggtatcgtcc ttgcgattcg caacgagctt 1583341 cacatcccgg ttaaactagt cggtttagga gaaaaagttg atgaccttca ggaatttgat 1583401 ccagaatcct atgtgtacgg actcttttca gatttagtgg aaaaagccga cgattaagaa 1583461 aaaggcccca acatcttggg gcctttttct tttttatctt cttacttgat aggcgaaatg 1583521 ataaaggctg ttatcagtgg ataccagtct tgactcacca gaaaaaactc tgaatgggat 1583581 gatgtcatag taatgaacgg aaacagatgt gtaatacgta tagtaaccag cagctggccc 1583641 caaatacatt ggaacctcaa atgttccgtt tgcatcagtc gttcctgaag cagtttgtgt 1583701 tgtgtttccg accttcgtgt ccgcttcaaa tcttacgggc gcgtttggca ctggctgtcc 1583761 gttttggtcg agtaatttgc cgcttactgt aatattgtac ttgactcgcc aatattgacc 1583821 ttgtccgtaa ttgattttac cgtatacccc tccatctgtg ctgatatttg tgattgaggc 1583881 cttataaggt gcctcagcag cgtctgcttg ctgtgccggg aaacctattg taaacagggc 1583941 tgccagacat aacataaaca ataaaccgat ttttttcata aaaatcctcc ttaaaatagg 1584001 gttcatatac aatatcggaa taaattggat gatatttagc gtattttgga aaagttaatc 1584061 gccgctttga caagataaaa acttgacagt gtcattaaaa ccgtgtaaac taagttatcg 1584121 taaagggatt tgacttaaca aaggggagag ctcaaatgtc actcgaaaag acaacgagaa 1584181 tgaattatct gtttgatttt tatcagtcgt tgttgacgtc aaaacagaag agctatatgt 1584241 cgctttatta tttggacgat ttctccctag gcgaaatagc cgaagaatat gaggtttcaa 1584301 gacaagctgt ttatgataac atcaaacgaa cagaagcaat gcttgaacaa tatgaagaaa 1584361 agctgctcct tttgaaaaag tttcaggagc gtaaagagat gtttaataag ctgaaggagc 1584421 ttgcttccgg ttcaaaagaa gaggaagaaa ttacagctct gattgaagcg cttgagaaat 1584481 tagattagga ggcggcaaac tatggcattt gaaggattag ccgaccgact gcagcagacg 1584541 atttctaaaa tccgcggaaa agggaaagtc agcgaacaag atgtaaaaga gatgatgcgt 1584601 gaggtccgtc ttgcgctgct tgaggctgac gttaacttta aagtagtcaa ggattttgtc 1584661 aaaaaagtaa gtgaacgcgc tgtaggccaa gacgtcatga aaagtctgac gcccggccag 1584721 caggtcatta aagttgttca agaggaactg actgagctga tgggcggcga agagagcaaa 1584781 atcgccgtcg caaaaaggcc gccgactgtt attatgatgg tcggtctcca aggtgccggt 1584841 aaaacgacaa caagcggtaa gcttgcgaat ctgctgcgca aaaagcataa tcgcaaaccg 1584901 atgctggttg ctgccgatat ttaccgccca gccgcaatta agcagctgga aacactcggc 1584961 aaacagcttg atatgcctgt tttctctctt ggcgatcagg tcagtcctgt agaaatagct 1585021 aaacaggcta ttgagaaagc caaggaagaa cattatgact acgtcatttt ggatacggca 1585081 gggcgcttgc atatcgacca tgaactgatg gatgaactga ccaacgtcaa agaaatcgcg 1585141 aatccggaag aaattttcct ggttgtcgat tcaatgaccg gtcaggacgc tgtgaatgtt 1585201 gccaaaagct ttaatgaaca gctcggttta accggtgttg tgttgactaa gctggatgga 1585261 gacacacgcg gcggggctgc gctttctatt cgcgctgtca caaacacgcc aattaagttt 1585321 gcaggtttgg gcgaaaagct tgatgcgtta gagccgttcc atcctgaacg catggcatca 1585381 aggattctcg gcatgggcga cgtgctgaca ttgattgaaa aagcacaggc cagcgttgat 1585441 gaagacaaag ccaaagagct ggaacaaaaa atgagaacga tgagcttcac attggacgat 1585501 tttctggagc agctcgggca agtcagaaac atggggccgc ttgatgagct tctgcaaatg 1585561 atgccgggtg caggtaaaat gaagggcctg aaaaacatcc aagttgatga aaaacagctg 1585621 aatcatgtgg aagcaatcat caaatcaatg actgttcttg aaaaagaaca gccggatatt 1585681 atcaatgcca gccggcggaa gcggattgca aaaggaagcg ggacatccgt acaggaagtc 1585741 aaccgtctgc ttaagcagtt tgatgaaatg aaaaaaatga tgaagcagat gacaaacatg 1585801 tcaaaaggca agaaaaaagg gtttaagcta ccttttatgt aatcggttat acatgataaa 1585861 accgttgtta agaaaaaaca ctttacaaac acttttatca ttgttaatat actatcttgt 1585921 tgaaatattt tcggaggtgc tagtaaaatg gcagtaaaaa ttcgtttaaa acgtatggga 1585981 gcaaaaaaat ctcctttcta tcgtattgtt gtagcagatt ctcgttcacc acgtgacggc 1586041 cgtttcatcg aaacagtcgg aacttacaac ccggttgcaa aaccagcgga agtaaaaatt 1586101 gacgaagagc ttgctcttaa atggcttcaa actggagcga aaccatctga tacagttcgc 1586161 aacttgttct ctagccaagg aatcatggaa aaattccaca acgctaaaca aggcaagtaa 1586221 tgactgatca acacttggaa gatttgattg tccacattgt gacgccgctt gttgatcatc 1586281 cagatgacat tcgcgtcata agagaagaaa ccgatcaaaa gattgcgctg cgcttatctg 1586341 tccataagtc agataccggt aaagttatcg gaaagcaagg ccggactgca aaagcgattc 1586401 gaacagctgt atttgcagct ggcgtacagt cttctaagaa agttcaattt gaaatatttg 1586461 actaaaaggg agagggccgg cacctcccct ttttttacac gcaaaaaaag ggtaaactga 1586521 tagaagctta ggcaaaatag aaaagcctgg acgagtaaaa gttttaaaag cggggagctt 1586581 ggtgcgatgc aaattattca ccgtgtagcc gttatgcaag tcttaaccga gcgcagtaaa 1586641 gaaaagcttt tagcttcttt tgctgagaag aaacaaatgc ttgaacgaga atgcagccag 1586701 ctctattttc agcttagaaa acatgagaaa gaacagcaaa accctaatat gattgaacaa 1586761 tttaaaaagg caatagaaaa gcgaaaagat gatataaaaa tcattgattt tcaaattgct 1586821 caagtacata cattgccgct tggcagtgag ttgaaagaaa aggaagtcga tgcgctgctg 1586881 acgattgaag ccggggatga ctggcatgag aaaacagcag cgaacaccat cgtcataaaa 1586941 gacggaaaag taattgaaat tcgccagagg tgatcatatg acaaagcgat ggtttaatgt 1587001 aggcaaaatc gtaaataccc acggaatcaa aggcgaagtg cgggtgattt caaaaacaga 1587061 ttttgccgaa gaacgataca agccgggaaa cacgctgtat ttgtttatgg acggccgtaa 1587121 cgaaccagtg gaggtaacgg taaacacaca tagactgcat aagcaatttc atctcctgca 1587181 gtttaaagaa agacaaaacc taaatgaagt agaagagctg aaaaacgcaa tcattaaagt 1587241 tcctgaagaa gaattaggag agctgaatga gggtgaattt tatttccacg aaattattgg 1587301 gtgtgaagta tttactgaag aaggcgaact catcggaaag gtcaaagaaa ttttgacgcc 1587361 tggagccaat gacgtttggg tcatcggacg aaaaggaaaa aaagacgcac tcattcctta 1587421 cattgaatca gtggttaaac atatcgatgt cagggaaaag aaaattgaga ttgaactcat 1587481 ggaagggtta atagacgaat gaaaatcgat tttttgacgc tgtttcccga aatgtttgaa 1587541 ggcgtgctcg gctcatcgat tcttcaaaaa gcccaggaaa aagatgcggt gcagtttcaa 1587601 gtcgtaaatt tccgagagta ctctgataac aagcacaata ctgttgatga ttatccttat 1587661 ggcggcgggg caggcatggt tctcaagccc cagcctgttt ttgacgcggt cgaggacctg 1587721 acatcaaagg cagccgctgc tccgcgtatt atcctcgtat gcccgcaagg tgagcgtttt 1587781 acccaaaaaa aagccgaaca attagctaag gaagagcatt tgctgttcat ttgcggccac 1587841 tatgaaggct atgatgaacg cattcgcgag cacttggtaa cggatgaaat atcaattggc 1587901 gactttgttc tgacgggcgg tgagctccct gcaatgatga tcgcagacag tgtggtcaga 1587961 ctgcttccgg gtgtactggg taaagaggct tcccatattg aggattcctt cagcaccgga 1588021 cttttagagc acccgcatta tacaagaccg gcagattaca aaggtttaaa agtgcctgaa 1588081 acactcttgt caggaaacca tgcaaaaatt gaagaatggc ggaataaaga atcgatcaga 1588141 aggacctacc taagacgtcc ggatctgttg aaagaccacc cgcttacaga gcagcaaaga 1588201 aagtggattt ctgaatggga aaaagaatag attttattgc ataggctatg aaattgtgat 1588261 aagatactac ttgtggctta agcgggctta tccgctgcaa gcttgaaaac gatgttccgc 1588321 tgtgccggtt tttgtggcca agagcatctg ttggaaggag ttgaaaacga tgcaaaaact 1588381 aattgaagat atcacaaaag aacagcttcg tactgatctt cctgcgttcc gtcctggtga 1588441 cactttacgt gtacacgtta aagttgttga gggtaaccgt gagcgtatcc agatctttga 1588501 aggtgttgtg attaagcgtc gtggtggtgg aatcagcgaa acgttcacag ttcgtaagat 1588561 ttcttacggt gttggcgttg aacgtacttt cccagtacac acaccaaaaa tcgcgaaaat 1588621 cgaagttgta cgttacggta aagtacgccg tgctaaactt tactacctgc gtgaacttcg 1588681 cggaaaagcg gctcgtatta aagagatcag acgataatga taacgaacga aaagagcttg 1588741 ttacctgtaa caagctcttt ttttatacag aatttgaaaa tgccggacag gcatcgtaaa 1588801 atacataaag gacaacaatg aatcatgcat actgaagata aaggcggtgt tcgtgtcaca 1588861 tgacaattca atggttcccg ggccatatgg caaaagcaag aagggaagta accgaaaaat 1588921 taaaattaat cgatatcgta tatgaattgg tagatgccag aattccaatg tcatcaagaa 1588981 acccaatgat tgaagatatt ctaaaaaaca agccgcgaat tatgctgtta aacaaggctg 1589041 acaaagcaga tgcggcagtt acacagcagt ggaaagagca ctttgagaac caggggatcc 1589101 gctctctgtc tattaattct gtaaatggac aagggttaaa tcaaattgtg cctgcatcaa 1589161 aagagatcct ccaagaaaaa tttgaccgga tgcgtgcgaa aggtgtgaag ccgagagcga 1589221 ttcgcgcttt gattatcggc attccaaacg tcggaaaatc aacgctcatc aaccggcttg 1589281 caaagaaaaa catagcaaaa acgggagaca gacctggtat tacgacttct caacagtggg 1589341 tcaaagttgg gaaagaatta gagctattag atacaccggg aattttgtgg cctaaatttg 1589401 aggatgagct tgtcggtttg agactggcag tcaccggggc tattaaagac tcgattatca 1589461 atttgcagga cgtggccgtg tttggtcttc gttttctcga agaacattac ccagaacggc 1589521 ttaaagagcg ttatggcctt gatgagatcc cagaggacat tgccgagctg tttgatgcaa 1589581 taggtgaaaa gcggggctgt ctcatgagcg gtgggctcat caactacgat aagacgactg 1589641 aagtcatcat tcgcgatatt cgcactgaaa agttcggcag gctgtcattt gaacagccga 1589701 cgatgtaaag gcgcgcagaa atgcgggtct ttattttttc ttggctgaac cgatacatac 1589761 agtaagggag aagagaaagt gaatacatta accgtaaagg acattaaaga ccgtttgcag 1589821 gaagtgaagg atgcacaaga cccatttatt gcccaatgcg aaaacgaccc gagaaaaagc 1589881 gttcaaacgc ttgtagagca atggcttaaa aagcaagcga aagaaaaagc gctgaaagaa 1589941 caatgggtga atatgacttc ctatgaaagg ctggcaagaa acaaaggatt tcgcttgatt 1590001 gcaggtgttg acgaggtcgg ccgggggcca ttggcaggac cagttgtcgc cagcgcagtc 1590061 atccttccag aggaatgtga aatacttggg ctgacagact ccaaaaagct ttcagagaaa 1590121 aaacgcgagg aatattacga gcttattatg aaggaagcac tggcggtcgg gataggaatt 1590181 gtagaagcta ctgtgattga tgagatcaat atatatgaag cttcaaaaat ggcaatggtg 1590241 aaagcgatac aggatttgtc ggatacacct gattatttgc ttgttgacgc aatgacactt 1590301 ccgctcgaca cggctcaggc gtcaattata aaaggcgatg ccaaaagcgt gtctattgcg 1590361 gcaggtgcgt gtatcgcaaa agtgacgagg gaccgaatga tgagcgctta tgccgaaacg 1590421 tatcccatgt acggctttga aaaaaataaa ggctatggga caaaagaaca tttggaagct 1590481 ctcgctgcat acggcccaac tgaattgcac cgcaaaactt tcgctcctgt tcaatctttc 1590541 agataaatca ccatggacaa ggaggcacct ttttaaaatg aacatacgaa atgatgtgca 1590601 aaaggcgctg cagcaccttt tcgggcgtac agccgtcccg caggaaacat caaaagtaaa 1590661 cgaagcgcta aacggggaga agcgtctcct cttaggaaaa gtgcttcgtt tactaggaga 1590721 tcagcatgcc ctgatccaag tcggcaatca aactgttcag ggaaaacttg aaactcagct 1590781 tcgtcctcag gcatactatt ggttttccta cgaaaaaaaa acggcagagc aaacaggccg 1590841 tcttcaggtc gttcaaagct ttgatcaaaa tcctaaaacc attcaggatg cagctggcaa 1590901 acttttaaat gctatttcag tgaagacgtc aaacgcagct ctcatgatga caggagcgat 1590961 gctgaaaagc aaaacacccg taacagaaaa tgatatcaaa acagctgtcc gctggatgga 1591021 cacgctgcct tcgcaagaca caaaaaaagc agttgaaacg gttctcttcg ctttaaagcg 1591081 tgatcttccc attcactccg agattttgaa tggtgttcac gctgtgaaat cgcctgttcc 1591141 gttgcatcag cacgtatccc agctgctaca ggcaatcgac caaaaccctc agcagagcca 1591201 aatgatgtca aagctaaagg aagcagtcac ggtgctttta aatagtgaaa tcgatgtcca 1591261 tgcagaacgg ctgattgata agcttatttc tttaaccgac aatacgaaag caccttctcc 1591321 gacgaataca gctggaagca gggagcttag cacaccagct ggctcccccg gaaaagccag 1591381 cctgccgatt gcaaatcaca cagcagaaca gggaagcata caagaagagc ctgttaaaac 1591441 agcagcagac attccaatta aagaagcccg ccagctgctg gtgaagctga cggaatctgc 1591501 tgaaaaaaac agtctccaaa ttgtgaaaga agcagcaaat tggattaaag cggctgcttc 1591561 atcgggtgat agtaagtcac ttgcagcttc agctgtttta caggcggcac aagtcacaga 1591621 tcaggaagcc gaagtctttt taaaggctgt tcagcagaca gcaccccatt tggcggataa 1591681 ggcagatgtt ctttctttct tatccaaagt gaaaacggca atcggcgcaa gggacgaggt 1591741 tgcgttcatt aaagcgtttg aacaaggaag cgcagtcaca tctggcgaaa tgcaatccat 1591801 caagctggct ctttctgcct taagagcatc gcatgaggta gccgaaccag tcaaacaaga 1591861 agccgatcag ctttttcata aattaaatgg ccagcttttc atgcagcagg accatccatc 1591921 atacagccaa attgtaatgt catttccgat gttttcgaag tcaggggttc aggacatgac 1591981 tgttctgttt aaaggaaaga aagaagcgga tggaaagctt gatccttccc attgccgcct 1592041 tttgtttttg ctgcagcttg atacactaaa agaaaccgtc gttgattgct tggtacagca 1592101 aaaagtcatg accattacaa tagagactga tttcgagctg caggctgcga tcgatccgat 1592161 ggtgcccgcg cttaaacagg ggctaaagga aatggggtac agcctttcag gggtaaacgc 1592221 taaaaaaagg gttcacaccg aagaaaaggc ttcaatcgat caatatataa caagtatcag 1592281 tgatcaggaa gtggatgtga aaatatgaaa gagcagacac cgatcagaaa agctgttgct 1592341 ctccattatg acgaacaaaa agacaaggcg ccgagagtga ttgccacagg gaagggccat 1592401 gtagctgaca acattataaa agaagcgaaa aaagcagggg tcccgattca agaagatcgg 1592461 acccttgtcg aattaatgcg ccatttgacg gtagatgatc aaattcctga agctctttat 1592521 gaaacggtag ccgagatttt ttcattcatt tacaaattgg acgaaagcgt aaaaaacaaa 1592581 aaatagctaa aatattcccc atccttcttt gaaatttatg tttttaataa agtaaaagtt 1592641 tgaatgttta gaaggattaa aagattttgc atcgaactgt agacaattct tccagtatta 1592701 ttatagaatg aaagcgcagt ctattttagt tttgttacat aagttaggag gatgggaaat 1592761 gaatatccat gagtaccagg gaaaagaagt cctcagaaaa tatggggtat ctgttcctga 1592821 aggtaaagtg gcttttacag cagaagaagc agttgagagt gcaaagagct tatccagctc 1592881 ggtttatgtc gtaaaggctc aaattcatgc tggcggtcga ggcaaagctg gtggggtaaa 1592941 aatagcaaaa tcattagacg aagtaaaagc gtatgccgaa gaactattag ggaagaccct 1593001 agttacacat cagacgggtc cggacggcca agtaataaaa cgcttactta ttgaagaagg 1593061 ctgcgatatt aaaaaagaat attacatcgg tctagtgctt gaccgcgcca cttcaagaat 1593121 cgttttaatg gcttctgaag aaggcggaac ggaaattgaa gaggttgcgg agaaaacacc 1593181 agaaaaaatc aaaaaagctg tcattgatcc agctgttggc cttcaaggct atcaagccag 1593241 agaaattgca ttcgctatta atattccaaa agagctcgtg ggaaaagctg ctaaatttat 1593301 gcttggacta tataaagcgt ttgttgagaa agactgctca atcgccgaaa tcaatccgct 1593361 tgttgtgact ggcgacggaa atgtgatggc gcttgatgca aaattgaatt ttgacagcaa 1593421 tgcgttgtac cgacaaaagg acattatgga atacagagat ttggatgaag aagatccgaa 1593481 agaaattgaa gcgtccaaat atgatctaag ctacatttcc cttgatggaa atatcggctg 1593541 tatggtaaac ggcgcgggac ttgcaatgtc tacgatggat attatcaagc attatggagg 1593601 agaaccggcc aacttccttg atgtgggcgg cggtgcaacc gcggaaaaag tcacggaagc 1593661 atttaaaatc attctttctg atcaaaacgt taaagggatt tttgtcaaca ttttcggcgg 1593721 cattatgaaa tgtgatgtca tcgcagaagg ggttgttgaa gcgactagac aagttggttt 1593781 gacattgccg cttgtcgtcc gtcttgaagg cacaaacgtg gatctaggga agaaaatcct 1593841 tagtgaatca ggattaaaca ttacatctgc ggaatcaatg gctgacggcg cgcagaaaat 1593901 cgtatcctta gtttaagaaa gaatgaaagg caggggacca aataatgagt gttttcatta 1593961 ataaagatac aagagttatt gtgcaaggga ttacaggttc taccgcttta tttcatacga 1594021 agcagatgct tgaatacggc acaaatatcg ttggcggtgt aacacctgga aaaggcggaa 1594081 cagaagcgga aggtgttcct gtatttaata cagtggctga agcagttcaa acaaccggcg 1594141 ctaacgcgtc tgttatatat gtgcccgcac cgtttgcagc tgatgcgatt atggaagcgg 1594201 tagatgcgga gcttgatctc gtgatttgta tcacagaaca tatcccggtt ttggatatgg 1594261 tgaaggtcaa acgcttcatg gaaggcaaga aaacgagact gatagggccg aactgtcctg 1594321 gtgtcattac gcctgaagaa tgtaaaatcg gcattatgcc cggatacatc cataaaaagg 1594381 gtcatgtagg cgttgtatca cgttcaggaa cattaacata cgaagcggtg caccagctct 1594441 cagaagcggg tgtagggcaa tctacagctg ttggaatcgg cggcgaccct gtaaatggaa 1594501 caaactttat tgacgtttta aaagcgttta acgaagatcc tgacacacac gcagtcatca 1594561 tgattggcga aatcggcggt acggccgaag aggaagcggc agagtgggta aaagccaaca 1594621 tgacaaaacc ggtagtcggt tttattggcg gtaaaacagc acctcctggg aagcgcatgg 1594681 ggcatgcagg cgccattatt tccggcggga aagggacagc tgatgaaaaa atcaaaaccc 1594741 ttaatgcatg cggaatcgaa gttgcagaga caccttctgt catgggtgaa accttaatca 1594801 aggtgctgaa agagaagaac ttgttcgaaa cttgtaaaac gcattaataa aaaagggaca 1594861 gccgtcaagg ctgttcctgc tttttctaac aaaaggaggt caatctattg gatcaggccg 1594921 ctgtctgcct aacgatttgc agaatcaatc aattattatc cccatccctt ctattaaaat 1594981 ggtggaaagc cgatccgtct atgtcgctga catcacccgt gttacaaacg gttactcgtg 1595041 atcaaataaa agcagctgca ttaaaaaacg aaatagaaca attttatcca aagctcccgc 1595101 gtgtacttgc tgcttatcgt gagcaaggca ttaacaccat ccctatttct tcaaagcaat 1595161 atcctttctg gcttaaaagc atttatgatc cccctgccgt actgtttgca aaaggtgata 1595221 tgactcttct ttcgaaaggg agaaaaattg gaattgtagg cacaagaaat ccaacagctt 1595281 atgggaaaca agttgtcaat catcttacaa aagagatctg tcgtaaaggt tgggtgattg 1595341 tcagcggact ggcgtctggg atagacggaa tgtcccatgc tgcaagtatt aaggcgaagg 1595401 ggcggacaat tggcgtcatt gcaggcggat ttcaacacat ttatccccga gaaaaccttc 1595461 agttagcaga tcacatggct aaacaccata tcctgctgtc agagcaccca cctgaaacta 1595521 aaccccaaaa atggcatttc cctatgagaa accgtattat cagcggacta agtgaaggcg 1595581 ttattgtcgt tcagggcaaa gaaaaaagcg gttcgctgat tactgcctat caagcattgg 1595641 aacaagggag agaggtattt gccgtacccg gttcattgtt tgacccttac gccggaggtc 1595701 ctataaaact gatccagcag ggggctaaag ccatatggtc agcagaggat attttcgagg 1595761 aacttcctga gagaaacgtt caatatacgg aacccttttg aattatcgtt tgacaaacgg 1595821 tattgtaata tttaataata gtgaggattt aaagttgcat attgttttct atttaattaa 1595881 tgacgttcat gataaagaat gaaatgttga aagccaaata aagacagctg caaaaataaa 1595941 attgaaatat cttgaaaaga gagagaacac ctcttgaggg ggatgaaaat gtctgattat 1596001 ctagtcatcg tggaatcgcc cgctaaggcg aaaacgattg aacgttactt aggtaaaaaa 1596061 tataaagtaa aagcatcaat gggacatgtc cgggatcttc caaaaagtca aatgggagtt 1596121 gacatagaac agaattttga accgaaatat attaccattc gaggtaaagg cccggtatta 1596181 aaagagctga aaacggctgc gaaaaaagcc aaaaaagtgt atctcgcagc tgaccccgac 1596241 agagaagggg aagcgattgc atggcatttg gcacacagtc ttgatttaga tctcaactca 1596301 gactgccgtg tggtgtttaa cgaaattaca aaagacgcta ttaaggaatc gtttaagcat 1596361 ccccgcatga tcaatatgga tttagtggat gcacagcaag cgagacgtat tttagacagg 1596421 cttgtcggat ataaaatcag tccaatctta tggaaaaaag tcaaaaaagg gcttagcgca 1596481 ggacgcgtgc aatccgttgc cctccgtttg attattgacc gtgaaaaaga gattaacgac 1596541 tttaagcctg aggaatattg gacaattgac ggtacgttct taaaaggtca agaaaccttt 1596601 gaagcgagct ttttcgggaa aaacggcaaa aaacttcctt taaatagtga agctgatgta 1596661 aaagagattc tttctcagct caaagggaat caatatacag ttgaaaaagt aaccaaaaag 1596721 gaacgcaaac gtaatcctgc tttgcctttt accacttcta ccctgcagca ggaagcggct 1596781 cgcaagctca atttcagagc gaagaaaacg atgatgattg cacagcaatt atatgaagga 1596841 attgatttag gaagagaagg aacggttggt ctgatcacgt atatgagaac ggattcaacc 1596901 cgtatttcaa atacggctgt tgatgaagca gctgcattta ttgatcagac atatggaaaa 1596961 gagttcctag gcggaaaacg gaagcctgcg aaaaagaatg aaaatgccca ggatgcccac 1597021 gaagcaattc ggccgacatc agttcttaga aaaccaagtg aattaaaagc agtcctcggc 1597081 agagaccaaa tgagactgta taaattaatt tgggagcgtt ttgttgccag ccaaatggca 1597141 ccggctgttc tcgatacaat gagtgtcgac ctgacaaaca acggtttgac atttcgtgca 1597201 aatggaagta aagtcaagtt ttccgggttt atgaaggtgt atgttgaagg aaaagacgat 1597261 caaatggaag aaaaagaccg gatgctgcct gacttacaag aaggcgacac ggtattatca 1597321 aaagatatag aacctgagca gcattttacc cagccgcctc cgcgatatac tgaggcccgg 1597381 cttgttaaaa cccttgaaga acgcggtatc ggccgtccat ccacatatgc tccgacactt 1597441 gatactattc agcggcgcgg ctacgtggca ttggataata aacgtttcgt tccgactgaa 1597501 ttaggtcaga tcgttcttga cttgatcatg gagtttttcc ctgagatcat taacgttgag 1597561 tttacagcta aaatggagag agatcttgat catgttgaag aaggaaatac cgaatgggtc 1597621 aagattatcg ataatttcta caccgatttt gaaaaacgcg tcaaaaaagc cgaatcggaa 1597681 atgaaggaag ttgagattga accagagtat gctggagagg attgtgaatt gtgcagttct 1597741 ccaatggtat ataaaatggg acggtacggt aaattcttag cttgctccaa cttccctgac 1597801 tgccggaaca cgaaaccgat tgtgaaacaa atcggtgtga agtgcccgag ctgcggagaa 1597861 ggaaacattg ttgagcgaaa atcgaaaaag aaacgggtgt tttacggctg tgaccgttat 1597921 ccggactgtg aattcgtatc atgggacaaa ccaattgaac gaaaatgccc gaaatgcgga 1597981 aaaatgctcg tcgagaaaaa actcaaaaaa ggtatacaag tccaatgcgt ggaatgcgat 1598041 tataaggaag aaccacagaa gtagcggtga gcagggtctt gctcaccttc tttgtgtgtt 1598101 aaaagaaggc cttgaataat aaactaggag atgtgaaaga tgaaccaaca aacagtgaat 1598161 gtaatcggag ccggactcgc aggaagtgaa gcagcatggc agcttgccaa acgtgggatt 1598221 caagtcaaat tgtatgaaat gcggccagtt aaacaaacgc ctgcgcatca tacagataaa 1598281 tttgctgagc ttgtctgcag caactctctt cgctctaata cacttgctaa cgctgtcggt 1598341 gtattaaagg aagaaatgcg tgcgcttgat tcagccatta tcgctgcggc tgacgaatgt 1598401 tcggtgcctg ccgggggcgc tcttgcagta gaccgtcatg aatttgccgc aagtgtgaca 1598461 aatcgggtga aaaatcatcc aaacgtaacc gttattaatg aagaagtgac tgaaattcct 1598521 gaaggcccta ctatcatcgc aacgggtccg ttaacatctg aatcgctgtc tgcccagctg 1598581 aaggagctga ctggagagga ctatttatat ttttatgacg cagcggcgcc aattgtagaa 1598641 aaagacagcc ttgatatgga taaagtgtac ctgaaatccc gttatgataa aggtgaagca 1598701 gcatatttga actgcccgat gacagaagaa gagtttgacc gttttcatga agcattaaca 1598761 tcagcagaaa cagtgccgtt aaaagaattt gaaaaagaga ttttctttga aggctgcatg 1598821 ccgattgaag tcatggcaaa acggggtaag aaaacaatgc ttttcggtcc gatgaaacca 1598881 gttggtctag agcatcctgt tacaggaaaa cgcccttatg ccgtcgttca gctcagacag 1598941 gatgatgctg cgggaacact ttataatatt gtaggattcc agacacattt aaaatgggga 1599001 gaccaaaagg aagttctcaa gttgattcca ggacttgaaa atgtagaaat cgtcagatat 1599061 ggcgtgatgc atagaaacac atttattaac tctccaagcc tgttaaagcc gacttatcaa 1599121 tttaaaaacc gcagtgatct gttctttgca ggccaaatga cgggagtaga aggatatgtg 1599181 gaatcagctg cctcaggact tgtagcaggc attaatgcgg cgaagcttgt attgggagaa 1599241 gagcttgtga tcttccctca ggaaacagca attggcagta tggcacatta tattacaaca 1599301 acaaaccaga agaacttcca gccgatgaat gcaaactttg ggcttttgaa agaattgcca 1599361 gttaaaatta aaaataaaaa agaacgaaat gaacaatacg cgaaccgtgc gattgaaaca 1599421 attcaaacaa tttcgaaaac aatataggta ttgattgcaa cctgagcgcg atttgtgata 1599481 ccatttaaaa gcccttcctg gggaggtatt aggcatggag aatgttaaga atttcgtaaa 1599541 gttattcgtt gaatatttac aaattgaaaa aaattattca caatatacta ttgtgaatta 1599601 tgtggattca attgaagaat tcgagacttt cctgcgcgtt caaggtataa atggatttga 1599661 agaagctgca tatcaagata ctaggatttt tttgacagaa gcctatgaaa aaggtttatc 1599721 gagaagaaca ataagcaaaa agatatctgc attaagaagc ttttataagt ttctgatgcg 1599781 ggaaaagctt attgaagaaa atccgtttca gcttgttcat ctgccaaaac aggagaaacg 1599841 gataccgaag tttctatatc aaaaagagct tgaggagctg tttgaagttt cagatataag 1599901 ccagccggcc ggaatgaggg atcaagcgct gttagagctg ctctatgcca ctggaatgag 1599961 ggtcagtgaa tgctgttcca taactattaa cgacgttgat ttatttatgg acactgtgct 1600021 tgttcacggt aaaggcaaga agcagcgcta tatccccttt gggtcttatg cccgcgaagc 1600081 gttgaaggta tacatgaata gcggaagaca gtgcttgctg atgaaggcaa aagaacctca 1600141 tgatctatta ttcgtaaatc aaagaggcgg accgcttaca gcccgtggca tcagacatat 1600201 tttaagcggg cttgttcaaa aagcgtcaag cactttacat atccatccgc atatgcttcg 1600261 acatacgttc gccacgcatc tgttaaatga aggagcggat ttgagaagcg ttcaagaact 1600321 gctcgggcat tccaatctgt cttctacaca gatatacacg cacgtttcga aggaaatgtt 1600381 gagaaacaca tatatgtctc accatccaag agcatttaag aaaaattaaa ggaggccctt 1600441 tatgtcatct tttcatgcga ccacaatatt tgccgtacag cataaaggac gaagcgctat 1600501 gtccggagac ggccaagtaa catttggtca ggctgttgtc atgaaacaca cggcacggaa 1600561 agtgagaaaa ctgtttaacg gcaaagttct tgctggtttt gcgggatctg ttgcagacgc 1600621 tttcacttta ttcgaaaagt ttgaagctaa gcttgaagaa tataacggca acttaaaacg 1600681 ggcggctgtt gagcttgcaa aggaatggcg cagtgataaa gtgctaagaa agctcgaagc 1600741 catgctgatt gttatgaatc aggatacttt gcttctcgta tcgggaacag gcgaggtgat 1600801 cgaaccagat gacggcattc tcgcgattgg atcaggaggc aattacgctt tggcagcggg 1600861 aagagcactg aaaaagcatg ccggggaaag catgtctgca agtgagattg ccagagccgc 1600921 gttagaaaca gcaggcgaaa tttgtgttta cacgaacgat caaatcatac tggaagagct 1600981 tgaatagaaa ggacttgagg cgcatggaaa aaaaaccgtt aactcctaga cagattgtag 1601041 atcggttaga ccaatatatt gtcggtcagc aaaatgcgaa aaaagctgtc gccgtggcat 1601101 taagaaaccg ctatagaaga agtcttctgg atgaaaagct gaaggacgag gtcgttccga 1601161 aaaacatttt aatgatgggt cctaccggcg tcgggaaaac tgaaattgcc agacgaatcg 1601221 ctaagctttc aggtgcgcca tttatcaaaa ttgaagctac taaatttacc gaagtcggct 1601281 atgtaggcag agatgttgaa tcaatggtca gagatcttgt ggagacttct gttcggctta 1601341 taaaagaaga gaaaatgaat gaagtaaagg aacaggcaga agaaaatgca aacaaacgca 1601401 ttgttcgtct gttagttcct gggaagaaaa aacaatctgg tgttaaaaat ccgtttgaaa 1601461 tgttttttgg aggcagccag ccgaatggtg aagatgaggc ggagagccag gaagaagcaa 1601521 acatcgaaga aaaaagaaaa cgaatggcgc atcagctggc tttaggagag ctcgaagact 1601581 actatgtaac agtagaagtc gaagaacagc agccttctat gtttgacatg ctgcagggct 1601641 cgggtatgga gcagatgggt atgaacatgc aggatgcgct gagcggatta atgccaaaga 1601701 aaaagaagcg gcgcaaaatg acagtcagag aagccagaaa agtcctgacg aatgaagaag 1601761 caagcaaact catcgatatg gatgaagtcg gccaggaagc tgttcagaga gcagaagaga 1601821 gcgggattat ctttatcgat gagattgata aaatcgcaaa gaacggcggt gcatcttctt 1601881 ctgccgatgt ttcaagagaa ggtgttcagc gggatatcct tccgattgtt gaaggttcta 1601941 ccgttgtcac aaaatatggt tctgtaaaaa cagaccatgt attatttatt gcagcaggag 1602001 cgtttcatat ggccaaaccg tctgatttga ttcctgagct gcaggggcgt ttcccgattc 1602061 gtgtagaact gaacaaactc acggtagacg acttcgtgag aattttggtt gagccggata 1602121 atgcgctgct gaaacaatat caggcattat tgcagacaga aggtatatct cttgaatttt 1602181 ctgacgaagc tattcataag attgctgaag ttgcttatca tgtgaaccag gacacagata 1602241 atatcggtgc gagacgcctt catacaatac ttgaacgcct attagaagat ttgtcgtttg 1602301 aagctccaga tgtaacgatg gagaaaataa cgattacacc acagtatgtc gaagaaaagc 1602361 tcggaacgat agccaaaaac aaagatttaa gtcaatttat attgtgaaaa atttaatatg 1602421 aggaatgttt aggaggatta tttatcatgg ctttattaca aaaaacaaga attattaact 1602481 ccatgctgca agctgcggca gggaaaccgg taaacttcaa ggaaatggcg gagacgctgc 1602541 gggatgtaat tgattccaat attttcgttg taagccgcag agggaaactc cttgggtatt 1602601 caattaacca gcaaattgaa aatgatcgta tgaaaaaaat gcttgaggat cgtcaattcc 1602661 ctgaagaata tacgaaaaat ctgtttaatg tccctgaaac atcttctaac ttggatatta 1602721 atagtgaata tactgctttc cctgttgaga acagagacct gtttcaagct ggtttaacaa 1602781 caattgtgcc gatcatcgga ggcggggaaa gattaggaac acttattctt tcgcgtttac 1602841 aagatcaatt caatgacgat gacttaattc tagctgaata cggcgcaaca gttgtcggaa 1602901 tggaaatcct aagagaaaaa gcagaagaaa ttgaagagga agcaagaagc aaagctgtcg 1602961 tacaaatggc tatcagctcg ctttcttaca gtgagcttga agcaattgag cacatttttg 1603021 aggagcttga cggaaatgaa ggtcttcttg ttgcaagtaa aattgctgac cgtgtcggca 1603081 ttacccgttc tgttattgtg aacgcactca gaaagctgga gagcgccggt gttatcgagt 1603141 ctagatcatt aggaatgaaa ggtacttata tcaaggtact aaacaacaaa ttcctaattg 1603201 aattagaaaa tctaaaatct cattaatcac aaaaagaacc ctttttgagg gttctttttt 1603261 tatttcaaat aaaggaaatc aataagcttt atttcctggg ttgaaagtct ttctatgtaa 1603321 taattttaat aaattttgca tttttcttca aaaagtttca aaaatgccga aaagaaagga 1603381 gaaaaaacag aaattctgct attttcaggc ttatatcaag gcgagaaatg tagttctaac 1603441 aatctaggac tttataccta gttgcaaaat agataattgt gaggacattt ttttacacga 1603501 acttcataga ctttatgcct gttatttctt acaataagca tatagtttta caattctcga 1603561 caaggatatt gagggtgaaa aaaactgaaa tggaggtaag tggatttgag cttattttct 1603621 ggaacgatac aaaatcttga aaatgccttg agcagagcgg atattaagca aaaagtcata 1603681 actaataata tcgccaatat agatacaccg aactataagg caaaaaaagt ctctttccaa 1603741 aatttattag atcaagaatc ctcgcgtctt gaagcgataa aaacagacta tcgtcatgtt 1603801 gatttttctg atactgattc gaattattca attgttgcga gcggagatac atcgtatcag 1603861 caaaacggaa acaatgttga tgttgacaaa gagatgacag aattggcgca aaatcaaatc 1603921 aactatcaag ctttggttga aagaatgaac ggtaaattta attcgctgaa gaccgtatta 1603981 acaggaggaa aatgatgaca gcttttcata gcttaaatgt ttcagcatcg gctttaacag 1604041 ctcagcgagt cagaatggac gttgtatcat ctaacttagc aaatatggat acgacaagag 1604101 ctaagcaggt gaatggagag tgggtgcctt acagaagaaa aatggtttcc cttcagtcaa 1604161 aaggtgaatc gttctcttcc attctcaatt ctcaaatgag cggaagcggg aatgctggaa 1604221 acggtgtgaa ggtttcaaaa attacggagg atgattcgga ttttaatctt gtctatgatc 1604281 cgacagaccc tgatgcaaac gctgaaggat atgtacaaaa gcctaatgtt gatccattaa 1604341 aggaaatggt tgatcttgtc agcagcacta gatcatacga ggcgaatgtc acggcgatga 1604401 atgccacaaa gggaatgctg atgaaggcgt tagaaatcgg aaagtaggtg aatgaatgtg 1604461 attaatgcaa tttctccttt tcaggttcaa aatactcaaa acactcaaaa tgcaacaaat 1604521 caagtaaaca atagccaaaa aacagattct tcaaatcaaa caagcttttc ggagctttta 1604581 aaaaactcta ttagttcgtt aaatgagtcc caagtagctt ctgacaacat gactaatgcc 1604641 ttggctgcag gaaaagatgt aaatcttgat gaggtcatga tcgctgctca aaaagctagc 1604701 atctctctaa ctgcagcaac agagttccgc aataaagctg tggaagctta tcaggagatt 1604761 atgagaatgc aaatgtaggg ggtctgacga tttagagaaa gagtggaatg accgggggtt 1604821 aacatgaatc gtactctaat gcaaatgaaa aacaaaacga gtgagttttg gaaaaataga 1604881 tctaaattac aaaagatttt aatggttagt gctttagcgg caattattat tattggaatt 1604941 attattagtg tttttgcttc aaattctaaa atggcgccgc tgtacaaaga tttgtctgcc 1605001 gaagaagcag gacaaatcaa agaagaattg gatgcaaaaa aagtgccaaa cgaactttcg 1605061 aatggcggta cagtgattag tgttccggag gatcaggttg attctttgaa agtgcagatg 1605121 gctgcagaag gacttcctaa aacgggatca attgattatt cgttttttgg acagaatgcc 1605181 ggctttggtt tgacagacaa tgagtttgat atggtgaaag tgaaagctac acagacagaa 1605241 ctgtcaaact tgatcaatga aatggacggt attaaaaatt caaaagtaat gattaatctc 1605301 ccgaaagacg ctgtgtttgt cggtgaagag caatctgcag catctgcatc aatcgttttg 1605361 cagattcaac cgggttatac acttgatcaa agccaaatca acggattata tcatctggta 1605421 tctaaaagcg tgccaaacct aaaagaagat aacatcgtca tcatggacca aaattctaca 1605481 tactacgaca aatcagacag cgatgcaggg tcctacgcgg atagttattc ttctcagcaa 1605541 ggaattaagt ctcaagttga aaaagacatt caaaaacatg tacagtcact gctgggtacg 1605601 atgatgggcc aagataaagt cgttgtctcc gttacagcag acattgattt cacaaaagaa 1605661 aatcggacag aagacattgt cgaacctgtg gataaagaaa acatggaagg cattgcagtc 1605721 agcgctgaaa aggtatctga aacatatcag ggcgacggtg cagccaacgg cggaactgcc 1605781 ggaaccggcg aggaagatgt tacaaattat aaggctgacg gtgaaaatac cgaaagcggg 1605841 aactacgaaa aaaacagcaa caaaatcaat tacgaggtta accgaattca taaagaaatc 1605901 gctgaaagtc cttataaggt cagagattta gggattcaag taatggtaga gccgcctgat 1605961 gccaaaaaca ctgcgtcgct atcaactgaa agacaggatg atatacaaaa aatcctttca 1606021 actgtagtca gaacatcttt ggataaagat gaaacgcaaa atcagaattt atctgatgct 1606081 gatatcaata ataagattgt tgtttccgtt cagccattcg acggaaaagt caatttggat 1606141 acaaatacgg aagaatcctc aggtatcccg ctgtgggcat atattgtagg cggtgtttta 1606201 atcgcagcga tcattgttct gatcattatg cttatcagaa agaaacgggc gcaagaggat 1606261 gaatttgagg aatatgagta tgaggttcct caagaaccaa tcaatttgcc tgatatcaac 1606321 gaagaggaaa atgaaacagc ggaatcagtc agacgaaaac agcttgaaaa gatggcgaaa 1606381 gacaagccgg aagattttgc aaaactgctg agaagctggc tggccgagga ttaggaggaa 1606441 ttagaaatgg cgagacgtga tcaagataag cttacaggaa aacaaaaagc agccattctc 1606501 atgatttcct tggggttaga tgtgtcagct tctgtctata agcacttaac cgatgaagaa 1606561 attgaaaggc ttactctgga aatatcaggt gttcgaagcg tcgatcatca aaaaaaggat 1606621 gaaatcatag aagaatttca taatatagcc attgcgcaag attatatttc tcaaggcggt 1606681 ttaagctatg caagacaagt tctggaaaag gcgcttggag aggataaggc ggagaacatt 1606741 ctaaacaggc tgacttcttc tttgcaggtt aaaccatttg attttgccag aaaagcggag 1606801 ccagaacaaa ttttgaattt tatccagcaa gagcatccgc agacgatggc gttaatcttg 1606861 tcttatttag atccagtgca ggccgggcaa attttatccg agctgaaccc tgaagtgcag 1606921 gctgaggttg cgagaagaat cgcggtcatg gatagaacgt ctccagaaat aattaacgag 1606981 gtagaacgga ttctggaaca aaaattatct tctgcattta ctcaggatta tacacaaaca 1607041 ggcggaattg aagctgttgt ggaagtgtta aacggggtag acagagggac agagaagacg 1607101 atcttggatt cattggaaat tcaggatccc gatcttgctg aagagattaa aaagcggatg 1607161 tttgtcttcg aagatattgt cacacttgat aaccgtgcaa ttcagagagt cattcgcgat 1607221 gttgagaacg acgatttgct cctttcatta aaggttgcaa gcgaggaagt caaagaaatt 1607281 gtgttcaaca atatgtcaca gcgtatggtt gaaaccttca aagaagaaat ggagtttatg 1607341 ggccctgtac gtttgaaaga tgtagaagaa gctcaatcaa gaattgtaag catcgtcaga 1607401 aagcttgaag aagccggtga aattgtaata gcaagaggcg gaggggatga tattattgtc 1607461 taatatcatt aaacaagaat catctatttc tccacaaaag gaaaaaagaa aactttctat 1607521 acaagaggtg cgtattgatc attctcacct tttgcaggct gaagagaacc cggaggcgct 1607581 tatggcccga gtgaaagagg aagctgaccg gatttctgag caggcaaaca gtcatataga 1607641 aaatattcgc cgtcaaattg aacaggagaa aaacgattgg gcggctgaaa aacagaagct 1607701 tattgaagaa gcaaaagccg agggctttga acaaggagta gcgctgggca aagctgaggc 1607761 aatgaaacag tatgcagaac tgatcggcca agcaaacagt ataactgaaa tgtccagaaa 1607821 agctgttgag gacaagcttg aagacgctaa tgaagaaatc gttgagcttg ccgttgccct 1607881 agcaaaaaaa gtttggcagc aaaagtctga tgataaagag gctttcctcc tgcttgtaca 1607941 acaggttata aacgaagtga aggaatatga cgatatatca atttatgttg atccatatta 1608001 ctatgagaca atctttcagc aaaaagatga aatccagcag cttctttata aagaatgtcg 1608061 gcttggcata tatgctgatg aaaaagctca aaaaggaacc tgttatattg aaactccttt 1608121 tggcagggta gatgcgagtg ttgacacaca attgatgcaa ttgaaagata aacttctgac 1608181 agcgctggaa gcaggtgcag ctgaatgaag acacagagtc tgatagattg tatagaaatg 1608241 acagactcgt ataaacggta cggaaaagtc aagcgggtaa tcggcttgat gattgaatca 1608301 aaagggccag caagctcaat tggtgacctg tgcctgattt atgcaaaagg acagtctggg 1608361 aaagtcatta aagctgaggt agtcggcttc caggaagaaa atattttgct tatgccttat 1608421 ttagaggctg cgagcattgc acctggcagc attgtagaag ctactgggga atcacttcgg 1608481 gttaaagttg ggaccggact gatcggacaa gtcatcgatg cttttggaga accgcttgac 1608541 ggaaagcttc tgccgaaagg gctttcgcct gtatcaacgg agcaatcacc gcctaacccg 1608601 atgaaacggc cgcctatccg tgaaaagatg ggtgttggag tcagatcaat tgacagcttg 1608661 ctgacagtcg gtaaaggcca gcggattgga atttttgcag gaagcggtgt cggaaaaagc 1608721 accttaatgg ggatgatcgc caagcagaca gaggctgact taaacgtcat tgcacttgtc 1608781 ggagaacgcg gacgagaggt tcgggagttt attgaaaaag atctggggaa agaggggctg 1608841 aaacgatcga ttgtagtcgt tgccacctca gaccagccag cattaatgag attgaaagcg 1608901 gcatatacag cgactgcaat tgccgagtat ttccgagata aaggccaaaa tgtcatgttt 1608961 atgatggatt ctgttacaag ggtggcaatg gcgcagcgag agattggact ggctgcagga 1609021 gagcctccga cgacaaaagg ctatacacct tcagtgttcg ctattttacc tcgtttacta 1609081 gaacgaacag gtgcaaacga gcatggaacc attacggcat tttatacagt gttggtagat 1609141 ggggatgaca tgaatgagcc gattgccgat accgtacgcg gaattttaga cgggcatatt 1609201 gtgttggaca gggcgcttgc caataaaggc cagtttcctg cagttaacgt actaaaaagc 1609261 atcagcaggg tgatgtcaaa catttcaaca aaacagcatc tggatgcggc aaataaattc 1609321 cgtgaacttt tatcgacata tcaaaattcg gaagatctca ttaatatcgg agcttacaaa 1609381 agaggatcat ccagagaaat tgatgaagcg atacaatttt atccgcagct tattcaattt 1609441 ttaaagcagg gaacagacga accggcttta ttggaagaaa gcattgctgc attaactagt 1609501 ttgacaggaa atgaggaata aacgtggctt atcaatttag attccaaaag ctgctggaac 1609561 taaaagaaaa tgaaaaagac caatccttat ccgaatatca gcaatcagtt tctgaatttg 1609621 aaaacgttgc tgaaaaatta tatgagaata tgagcaaaaa ggaattgctg gaacaaaata 1609681 aggaaaagaa attaaaaagc ggcatgagtg tacaagaaat gaggcactac caacaatttg 1609741 tctcaaatct tgataatacg atctatcact atcaaaagct tgtcattatg aaaagaaatc 1609801 aaatgaatca aaaacaagaa attttgacag agaaaaacat tgaagtgaaa aagtttgaaa 1609861 aaatgcgtga aaaacagttt aaaatgtttg ctcttgaaga taaagctgca gaaatgaaag 1609921 aaatggacga tatttcgatt aagcagttta tgattcaagg ccattaggag cgaatgtaat 1609981 gtccggcaaa aagaaagaat caggtaagtt ccgttcggtt ttgcttatca ttatcctccc 1610041 gctgatgttt ctattaatcg caggggggat tgttctttgg gctgctggta tcaatgtctt 1610101 aaagccgata caggatgctg cggcaaaaac gccggttctt aaagaattgg tccctgaaac 1610161 cgaaaataaa aaaggcgcag catcaagtaa ggatagcagt aatacggcag ctctggaaaa 1610221 gaccattaag gatcaaaaaa gtgaaatcag tatattgaat aaagatttag aaacaagtaa 1610281 atcagaaatc gacaggctca atcaaaagat ccgttcactt gaaaagacgg ctgaggatca 1610341 aaaaaagtca tcagaagatc atactgaagg atcagcagac tcgaaagctt cttctgaaaa 1610401 tgacaaagtg atcagtgtgt acaaaagcat ggacagcgga aaggctgcta aaattattgc 1610461 ccaattaaag gagcaagaag cactgaaaat attgaatggc ctaagcaaaa agcagcttgc 1610521 tgacatattg gcgaaaatga ctcctgagca agcagcaacc tatacagaaa aaattgctgc 1610581 cagccaagaa tagggggaat gaaaggtgaa gctgcttgaa ttagccggac ctttgctgca 1610641 aaccacaacg ggttctgccg ctaaaaacat gaaaagtagc cagggagttt ttcaaaactg 1610701 gcttatgtct gaggctggat tgaaggaact ttcagaacaa ggaaagggaa ctcctaattc 1610761 tgaagatcag cttttagcag atgcgcttaa aaagatcggt gaatggctaa atgcaagtcc 1610821 tgaagatcaa gacaaacaaa atgcggatct tttgcaaaca ttaagcaaac tgacagggaa 1610881 gcaattggat gcgaatgctc tgcaaatgtt gcaaaatctt ttgcaagcag ttgaatcaaa 1610941 aatgtcaggc gggacggatc aattgctcac agaaacggag aaaatctttt cagaagctaa 1611001 aacggctctg agtgccaatg attctgcttc tgacattaat ggagcactga agtctgataa 1611061 agagcaatca aatcaggaaa atgaagtatc cgagcctgca aaagagctta tctatatcca 1611121 gatgttcatt agccagctcg tagaagggaa taagctgact gatctcggga atggcaatga 1611181 agctcatgcc atttaccaaa atggagatca attcctttct gcattagaaa agaagggtgt 1611241 atctcaacaa ctaattcagg atcttaaaca gcaaatattc actaaagctg agtcaagttc 1611301 aaaactttac tcgatgacag cgtcagagct gaaaagtttt caaagcttaa tggatcaaat 1611361 gtctatgctt cctcaaaaag ggaccaaaga atggagttta gctgaaagcc agctgaaagc 1611421 cttcttgtta tcgaaatcat ccgaatcatc acaagacttt gggaagagtg ttctcacacc 1611481 gctctcgcag agttcatcca gcaaaaatgc atcggatgtt tctggaagta ttcagcctgt 1611541 agatagtaaa tcaggactcc aaatgctgtt ttcggggtat cggggcatag gaggagttca 1611601 aacacttgat ctgcagcaga tgtcatctga tataccaaat gccgaaacaa aaacggtggc 1611661 tgatcaagtg attaatgcgt ggaagcagat gaaatatacg cctttcggca gatcgacggg 1611721 aagtttcact attcggctga accctgaaca tttaggattt gtcacaatca agctgacaaa 1611781 tgaaaatgga atgtttcaga gtaaaatcat agcatctagc caatcagcaa aagaattgct 1611841 tgaacagcat cttcctcagc tgaagcaatc attgccgaat atggccgtcc aaattgaccg 1611901 ttttactctt ccggtccaaa gcggggatca gccgatatac ggccagcttg ctgatgaaca 1611961 gaaacagcag caagaggggc agagacagca aagacagaaa aagcaatcaa atgattttgg 1612021 cgatctgctc gatgaagtgt cgatggttga aatggaggaa gaagaatgac ttctataagt 1612081 tcagaatata aactgcctga aaaaacgaac actgtgtcga cgaacaacag cagcttgggg 1612141 aaagacgagt ttttaaaaat attaatgact caagttcaaa accaagatcc gcttaacccg 1612201 attgacgata aagaatttat cagccagatg gcgacttttt caagcttgga gcaaatgatg 1612261 aatctgaata cgacaatgac tcaattcgtt gaaaaccaag atccgtttac aacgtatgtt 1612321 gattggatgg gaaaagaagt atcttggact gatggtaaaa gtgcaacaga taaaacaggc 1612381 acagtaagct ctgttaaaca ttttaaagga aattattatc tcgttcttga tgatgggacc 1612441 gagatcagtc ctgcgaatgt catgtctgtg ggacaatcat ctaaataaaa acatctgggg 1612501 gaatatatta tgttacgttc actttattct ggaatcagcg gtatgaaaaa ctttcaaaca 1612561 aagcttgacg taatcggtaa caacattgcc aacgtaaata cagtaggatt caaaaagagc 1612621 cgtgtgacct ttaaagatat ggtaagccaa acgattgccg gcggttctgc tgctggtgca 1612681 acaatcggcg gaacaaactc taagcaaatc ggtttaggtt catcatctgg cacaattgat 1612741 acaattcatt caacaagcgc gacacaaagc acaggaagaa cacttgattt agcaattgac 1612801 ggcgacggtt acttccgaat tgatacaggt gacgggacag cttatacaag agcagggaac 1612861 ttctatttag ataatactgg aacactggtt acaggtgatg gctaccatgt actaaatatg 1612921 aatggcggaa caattaaaat tcctactgat gctcaaagct ttagcattgg ttctgatgga 1612981 aaggtgtcaa ttgttgatgc tgaggggaaa acacaagacg ggggacaaat cgggattgtt 1613041 acttttgcca acagtgatgg attggataaa atcggaagca acctataccg tgaatcttta 1613101 aactctggaa cggccagtgc agcgaaccag cctggtgacg gcggaactgg tgctcttaaa 1613161 tcaggatttc tcgaaatgtc taacgtcgat ttaactgacg aatttactga aatgatcgta 1613221 gcccagcgcg gattccaatc aaactcaaaa attattacaa catctgatga aatccttcaa 1613281 gaactggtta accttaaacg ttaaggaggg aggggaggcg agtaatcgct tctccgctgt 1613341 tttatgatta aagtaacccg tttgaacggg cagcccttta cactgaatgc gctatttatt 1613401 gaacagattg aatgttttcc ggatactaca attactctgt caaatggtaa gaagtttgta 1613461 gtaaaagaag atgaagaagc tgttctggaa aagatcgcag ctttctaccg aaaaatacaa 1613521 atatttgcaa tggatcaagg aatagaggaa ccggaatgaa gaaaaagtta atgatcatat 1613581 tactaattat tcttatcgta attggtgctc tcggggcggc ggcttatttt gttttaggcg 1613641 gaaagtccga aaaaagtgaa gcgaaaaaaa gtattgatga aatcgttgcg tcttctgttg 1613701 atgtagaaga gatcacaaca aatttaaagt ctgataacat tatccgtctt gctattaaac 1613761 ttgaaactga ttctgataaa tcaaaagaag aacttgagaa acgtgatttc caagtgaaag 1613821 acgctgttat atcactgctg gctgatacga atgctgatca gattgaggga gacaagggaa 1613881 aagaaacctt taagaaggaa ctaaaagata aaataaatag ctacctccaa gaaggaaaag 1613941 tagaaaaagt gtatattacc tcctttaatc tgcaataaag cataatttga cagaatacgg 1614001 aggtgaggaa aatgtcagga gaagttctct cccaaaatga aatagatgca ctgctctctg 1614061 caatatcaac tggtgaaatg gacgctgaag agctgaaaaa agaagaaaaa gagaagaaag 1614121 tcaaggttta tgatttcaaa cgtgcgctgc ggttttctaa ggatcagatc cgcagtttaa 1614181 cgagaattca tgacaatttt gcaagacttc ttaccactca tttttctgct cagctcagaa 1614241 cctatattca catatctgtc agttctgttg atcaggttcc gtatgaggaa tttatcagat 1614301 cgattccaaa catgacgatt ctgaatctat ttgatgttca tccgatggaa ggaagaatta 1614361 tgatggaggt caaccccacg atagcttata cgatgatgga tcgagtcatg ggcgggattg 1614421 gaatcagtca taacaaggtt gacagtttga cagaaattga aacaaaaatc atttctaatt 1614481 tatttgaaaa tgcactgggt aattataaag aagcttggca gtcaattgct gatattgaac 1614541 cggaaatgac tgagtttgaa gtgaatccgc aatttgttca gatggtatct cctaatgaaa 1614601 cagtcgtggt gatctcgctc aatactcaaa ttggtgaaat cagcggtgtc attaatctct 1614661 gtatcccgca tattgtactc gagccgctca taccgaagct ttcagtccac tattggatgc 1614721 aatcagaccg aaatgagcca aagcctgagg aaacaaagtc gcttgaaaaa cgtatcatga 1614781 cagcacaaat acctgtcgtg gccgagctcg gcacatctga actgacgata gaagagtttt 1614841 taagtttaga agtcggagac tgcataactt tggacaaatc agtcacggat cctcttactg 1614901 tattggtcgg agataagccg aaatttttag gacaagccgg ccgggtgaat cgaaaacagg 1614961 cagtgcaaat tttagatcac gacataagag gtgaacaaga tggagaataa tagattatct 1615021 caagatgaga ttgacgcgct tcttaacggt actggcagca cgcttgatga gccagagatt 1615081 ccggaagtag atgacttatc ggaaatggag cgtgatgcga tcggtgaaat cggtaatatt 1615141 tcattcggca gttctgcgac agcactgtca acgcttttaa atcaaaaggt cgatattacg 1615201 actccaagcg taacggtcat tccaagaagt aaaatcagcg atgcgtttcc tgaaccgtat 1615261 gtagcgattg aagtgaatta tacggagggc ttcagcggaa gcaacctgtt agtcgtggaa 1615321 caaagtgacg cggcgatcat tgcggactta atgatcgggg gagacggaaa aggtgcggac 1615381 ccttcactgg gtgaaatcca tttaagtgcg gttcaagaag caatgaacca aatgatggga 1615441 tcggctgcca catcaatgtc tactgtattc agtaaaaaaa ttgatatttc acctcctcgg 1615501 gttgaattgc tggatgttac tgaagaaaag ggtacagacc gtattcctga tgatgaaatg 1615561 ctggtgaaag tttctttcaa cttaaaggtg ggagaattaa tagactccag cattatgcaa 1615621 ctttacccat tgacatttgc gaaagattta atttcaagcc ttatgaactc agaaagtgca 1615681 gaggaagaag aaacggtgca gcctgaagtt acatacgaac agccgaaaga gcctgtgacg 1615741 ccagagccgc gtattgaacc gaagcaacag cagcagccgc caaaaaggca gggaacagca 1615801 aaaaaagcag cgccagttca ggtttcaccg gtggaatttt ccgcgtttga tccaaacgaa 1615861 gctgtacaag cccctattca taatctggat atgcttttgg atatcccgct ttcgattact 1615921 gttgagcttg gcagaacgaa gagaagcgta aaagagattt tagagctttc tgccggaagt 1615981 attatcgagc ttgataaatt agccggtgag cctgtagata ttttagttaa tcagcgtatc 1616041 gttgccaaag gcgaggtcgt tgtcattgaa gaaaacttcg gagtgagagt cactgacatt 1616101 ttaagccagg cagagcgcat taataattta aaataacgaa acacaaggag agagatagat 1616161 tatggcacat agaattttaa ttgtagatga cgcagcattt atgcgaatga tgattaaaga 1616221 tattttggtt aaaaatggtt ttgaagttgt ggcggaagct gaaaatggag cacaagcggt 1616281 agagaaatat aaagagcatt cacctgacct tgttactatg gatatcacga tgccagaaat 1616341 ggatggtatt acagcattaa aagaaattaa acaaattgat gcgcaggcaa gaatcatcat 1616401 gtgttctgct atgggacagc aatcaatggt tattgatgcc attcaggccg gcgctaagga 1616461 tttcattgtg aaacctttcc aggctgaccg tgtgcttgaa gcaatcaaca aaacattaaa 1616521 ttaaagggtg tacgactgtt gaaaaagagt caatatttta ttgtttttat ttgttttttc 1616581 gttttattca gtgtacatcc gattgctgct gccgcggcag actctgataa ttcaactgta 1616641 aacgaatggt ttcaaaagaa agatgaaaaa actgcagatc aatcagagca aaagaaagaa 1616701 aaaacaacaa aaactgctga tgagacggag ggagcggctg ctccttctgt ctcagctttt 1616761 gattttgtaa agatgatttt cgctttactg tttgttatcg tgctgattta cgggctggtt 1616821 aagctcatga acaaaagaaa tcggctccta aagccttttc aatatgttga aaatattggc 1616881 ggcacatcgg tcggtcagaa cagatccata caattgatca aggtcgggaa aagtgtgctc 1616941 gtcgtcggtg taggagagac gatccagctg ctgaaagaaa ttgaggatga aaaagagatt 1617001 gaagtcattc tcagtcagca tgaagaggca atgtcaagca aaatagagtg gcaaaagttt 1617061 gtgaagccgc ttaagagttc tgaacatcag ccgcagcaaa aactgccttc attttcaaaa 1617121 gcattaaaag agcaacttga agagttaaaa caaaaccgtt ctgaaggaaa gaagaaaggc 1617181 ccacgtcatc atgaatgagt ttataaatat tttcagttca agcgatccgg aaaacgtaag 1617241 ttcgactgtt aaattactat tattgttaac tgtattttca gtggcgcctg gaatattgat 1617301 tcttatgact tgttttactc gcatcgtcat tgttctgtca tttgtcagaa cttcacttgc 1617361 gacgcaatct atgcccccaa accaggttct aatcgggctt gcgctgtttt taacattttt 1617421 tattatggct cctacttttt cagaaattaa taaagaagcg ctgaccccat taatggacaa 1617481 caaaatcagc ttggatgaag cgtatacgaa agctgaggaa ccgattaaag aatttatgag 1617541 taaacacaca aggcagaagg atctggcgct gtttatgaat tacgcgaaaa tggataaacc 1617601 tgaatcatta aaggatattc cgttaacaac aatggttccg gcttttgcca tatcggagct 1617661 taaaacagca tttcaaatag gttttatgat ttttatccct tttttaatta tagatatggt 1617721 agtggcgagc gtcttgatgt caatgggaat gatgatgctg cctccagtta tgatttctct 1617781 gccctttaaa atattacttt ttgttttggt agacggctgg tatttaattg tgaaatcttt 1617841 gcttcagagc ttttagggta ggtgctaaac gtgagttcag aatttgtaat ttctatggcg 1617901 gaaaaagccg tatacgtaac gctgatgatc agcgggccat tattggctat tgctttactg 1617961 gtcggtttaa ttgtcagcat atttcaggcg acaactcaaa tccaggaaca gactttggcg 1618021 tttattccga aaatcgtggc ggttctcctg gctctcattt tttttggtcc gtggatgctg 1618081 tcgacgattc tttcatttac aacagagctg ttttctaatt taaatcgttt tgcagggtaa 1618141 tgtagagatg aattcaatta ttgacttatt tcctgctttt ttattggttt ttattagaat 1618201 ctctgctttt tttgtaacga ttccgctatt tggacatcga aatgtgccag ctgttcatcg 1618261 cataggtttt gctttttttc ttgcggtcat ttgtttcagc accattgata aaccgccctc 1618321 tttggagata gatgagcact atatgctttt ggcgtttaaa gaagctttgg tcggcctatg 1618381 tctgggttta attgcttata tgatgattgc cgcagtgcag attgccggct cgtttattga 1618441 ttttcaaatg ggattttcaa tagcaaacgt tattgatccg caaaccggtg cacaaagtcc 1618501 gttgattggc cagtttatct atacgatggc acttttgttt atgctgagtg tcaatgccca 1618561 ccatttgttg ctggatggta tttactacag ctttcagtat atttcagttg atcaggcatt 1618621 tccgaatttc ggcgatgaaa agtttgccta ttttattgcg aaaagcttta atgcaatgtt 1618681 tattatcgct tttcaaatgt cagcgccggt tgtggccagt ttgtttctag ttgatttagc 1618741 attaggtatc gtggctcgaa ctgttccgca gttaaatgta tttgtggtcg gtctgccttt 1618801 aaagatcgct gtcagtttca ttatgctcat tgtatgtatg tccgttatct tcgtcgttgt 1618861 ccggaatgtt ttcagtttaa cgattgaaac gatgcggaat cttttagcat tggtcggtgt 1618921 ttcttaatga agcttagagt tgacctgcag ttttttgcgg gagagaagac agaaaaagcc 1618981 actccgaaaa aacggaagga tacgcgaaaa aaagggcagg tagccaaaag ctcggatgtc 1619041 aataccgccg tttctttact ggtaatattc ctttcgctta ttgcaattgg tccgtatatg 1619101 agagacaggc tgctgtcatt catagaaaca ttttataccg aatcgctcac aatgaagctc 1619161 tcagaatcaa atgtgcatac attgtttgtc agcttattaa aggatatggg catgatactc 1619221 gcaccgatct tgcttgttgc tcttgttgca ggagtcgtaa gcaactatat gcaggttggg 1619281 ttcttgtttt ctgctgaagt gatacagcct aagcttgaaa aactggatcc gatcaaaggc 1619341 tttaaacgaa tatacagtat gagggcgatt gtagagctga ttaaatcaat tttgaaaatc 1619401 gtagtcgtcg gttttgcggc ttttgctgtg ctttggctgc attatggaga aattctccgg 1619461 cttcctctcc tgacacccga agaggcactt tctttcgttt caaaactcac tttgtggatg 1619521 ggactaagcg gtgcaggtgc attgttgatt cttgctggtc tcgactattt atatcagaga 1619581 tttgactatg agaaaaatat caaaatgtca aaacaagata taaaagatga gtacaaaaaa 1619641 tctgaaggag acccgattat caagtctaaa attaaacaaa gacagcggga aatggcgatg 1619701 aggcggatga tgcaggaagt tccaaaagca gatgtcatta tcacaaaccc gactcactat 1619761 gcgattgctt tgaaatatga tgaagaaaaa atggacgcac cttatattgt tgcaaaaggc 1619821 gtcgaccacc ttgcgttaaa aatcaggaaa attgctaaag agcatgatgt catgatggta 1619881 gaaaacagac cgcttgcccg tgcgttatat gatcaagtgg aaattgacca ggcagtgccg 1619941 gaagaatttt ttaaagtttt agcagaaatt ctggcttacg tatataaaac aaaacaaaaa 1620001 gtatattgaa tttttcgatt taaaaggaga gaaaaaacag catgtcaaca agagatttat 1620061 ccgttttaat aagtgttgtc ctcattgtgg cgatgctggt gattccattt cctccatggc 1620121 tgttaagtat tttgatcatt attaatattt ctcttgcgtt gatcgtgctt ctcaccacaa 1620181 tgaatatgca ggaagcgctt cagttttcga tttttccgtc actgttgctg cttttgaccc 1620241 tatttcgttt gggcttgaac gtctcaacta cccgttcaat tctttcacac ggtgagggag 1620301 gtaaagtcgt cgagactttc ggaaatttcg ttgtcggcgg aaatgtatta gttggactcg 1620361 ttgtatttat catccttatt attattcagt ttatcgtcat tacaaaaggt gctgaacgtg 1620421 tttccgaggt tgcagcaagg tttacgctgg acgcaatgcc ggggaagcag atgagtattg 1620481 atgctgattt aaacgcaggg atgattaccg aacaggaagc gaagcatcgc cgcgaaaaag 1620541 tggcaagaga agcagacttt tatggagcaa tggacggtgc cagtaaattt gtaaaaggtg 1620601 acgccattgc cggaatcatc attgtgatga tcaatattat tttcggaatc gtgatcggaa 1620661 tgcttcagca gggcatgtcc attcaagaag ctgcttcaca ctttacgatg ctgactgtag 1620721 gggatggaat tgtttcgcaa atcccggcac tgttaatttc tacggctacg ggtattgtgg 1620781 tcacaagagc tgcatctgaa ggaaacttag ggcatgacat tacaggccag ctgtttgcgt 1620841 atccaaagct tttatacgtc gcagcagcta cgatcatgct tttaggtatt ttcactccga 1620901 tcggcatcct tctgacgggg ccgcttgcgg gattgcttgc ttttggcgca tatacactat 1620961 ctaaatcagg taaggaaaaa gaagaagtgg atgagattct tgaggaagag gctgaggtgg 1621021 acgagcttaa aagccctgaa agtgttgttc agcttctgca tatagatccg atagaatttg 1621081 agtttggata tggcctgata ccgcttgctg atgccaatca aggcggtgat ttattagacc 1621141 gaattgttat gatacgccgt cagttggctt tggaactcgg gcttgtcatt cctgtcgtgc 1621201 gaatcagaga taatatagcg ttgcagccta atgaataccg attgaaaatt aaaggaaacg 1621261 aagtagcaaa aggcgagctg ttgcttgatc attatttagc gatgtcgcct actcctgagg 1621321 acgatctcat tgaagggatt gaaacagtgg agccttcatt cggactgccg gctaaatgga 1621381 ttagcgaagc ggtaaaggat gaagccgaca tgcttggtta tacagtagtt gatcctgcat 1621441 cagtcgtttc aacgcatatt acggagaaaa ttaagcagca tgcccacgaa ttgatcggaa 1621501 ggcaggagac aaaacagctg atcgatcact tgaaagaatc gtatccagtc ctggttgaag 1621561 aggttacgcc gaatccattg tctgtcggtg atattcagaa agtgcttgct aagcttttaa 1621621 aagaaaaagt ttcaattcga aacttagtaa cgatttttga aacacttgct gactatggga 1621681 aattaacaac agattctgat ctcttgacag agtatacaag acaagcgctt gctaaacaaa 1621741 ttacagccca gtttgccaaa gaaaatgaag tgttgaaggt tgttacttgt tccggccgtg 1621801 tagaaaaagc aatagcagac ggtgtgcagc agacggaaca cgggaactat ttatcacttg 1621861 aaccagatat ttcagaaagt atagtgcgct ctgtcgccaa agaagctgaa cagctctcat 1621921 tacgtcagga aaccgcgatt cttctttgct cgccgcctgt cagaatgtat gtgaagcagc 1621981 tactggaacg gtacttccct gatcttccgg tactctctta taacgaactt gaggcgaatg 1622041 ttgaggtaca aagcattgga gtggtggata tttaatgaaa ataaaaaaat ttactgctgc 1622101 ttcaatgcaa gaagcggcac ttctcatcag aaaagagtta ggtaatgaag cggtcatatt 1622161 aaattcgaaa aaaattaaaa agcgaaaatg gtttggcctc gtcaacaagc ctgctgttga 1622221 agtaatcgcc gtattggatc aggactttct tgagaaaaaa acgcctcaga aggcagctga 1622281 accgaaacaa acattaaaaa ctccggtcag cagtccaaaa atagaggaga gaacatatcc 1622341 ccctcaaatt ccggcgcaac aggagctagg tgatttttca gcatatcaat ctgtacttcc 1622401 tgagccgctg cgaaaagcag aaaagctttt gcaagaaaca gggatcaaag agtctacgaa 1622461 aacgaacact ctgaaaaaat tgcttcgctt ctctgttgaa gcaggcggct tgactgaaga 1622521 aaatgttgtc ggcaaacttc aggaaatact atgcgatatg ctgccctcag cagacaagtg 1622581 gcaggagcca attcattcaa aatatatcgt tctctttggt tcaacagggg ctggtaaaac 1622641 aactacactg gctaaactcg cagccatatc tatgcttgaa aaacataaaa aaatcgcttt 1622701 tattacaaca gatacgtatc gtattgcagc tgttgaacag ttgaaaacat acgctgaact 1622761 gctgcaggct cctctggaag tttgctatac aaaagaagaa tttcagcagg cgaaggagct 1622821 attttctgag tatgatcatg tgtttgttga tacagctgga agaaacttca aagacccgca 1622881 atacattgat gaactgaaag aaacgattcc ttttgagagc agcattcagt catttcttgt 1622941 tttatccgcg actgcaaaat atgaagatat gaagcatatt gtcaaacggt tttcatccgt 1623001 ccctgtcaat cagtatattt ttacgaaaat agatgaaacg acttccttag gttctgtatt 1623061 taatatactg gcagaatcaa aaataggtgt cgggtttatg actaacggcc agaatgtgcc 1623121 tgaggatata cagactgtat ctccacttgg ttttgtgagg atgctgtgca gatgaacaga 1623181 tatgaccaag cagcaacttt acgggcgaaa atggaaaaac gtgagcgcgt tctgccaatg 1623241 gtttattcac aaaaagcgaa gacacttgct gtcatcagcg gcaagggcgg tgtcggaaaa 1623301 tccaatatta ccttaaatat ggcacttgcg ctgcaggata aaggtaagaa ggtgctgctc 1623361 atcgaccttg atatcgggat ggggaacatt gatatattaa taggaaattc atcgtctgcc 1623421 acgataatcg atgttttaac cgatcgtaag cctttgctgc agtcattatc cgttggccca 1623481 aagggtttgc ggtatatatc agggggaacc ggtcttgatg tgatgtttca gctcgatcag 1623541 agaaaatgga cgttttttgc caatgaactt tctcatgcat taagccagtt cgattatgtg 1623601 ctgtttgaca tgggagcagg cttatcaaaa gatcaactgc cttttatttt atcagcagaa 1623661 gatattttga ttattacaac tcccgagccg acggccatta tggacgcata cagcgctgtc 1623721 aagcacttgg ttttgacaga aaataagctt tcaatgaagg tggctgtcaa tcggtgccgt 1623781 gaccaaaagg aagggcttga cgcttttgcc cgcctctccc gtacaattca tatgtttttg 1623841 gatgttcagg ttcagtttgc cggttccgtt tctgacgatg tgatcgtgag caaagcggtt 1623901 gtcgaacagg ttcctttttt cataaaaagc cctcaggcaa aagccagccg gtcagtccgt 1623961 attttagcgg acgccttgtt tgaaagagaa gaaacgagac acaaagaaga caaacagaca 1624021 tttattgaga aattatcttc ttttttaatg aggagggctt aatttgattc gtgtgcttgt 1624081 agttgatgat tcagctttta tgagaaaaat gataagtgat tttctgaccg aagaaaagca 1624141 gatagaagta atcggaactg cgagaaacgg agaagaagcg cttaagaaga ttgaattatt 1624201 aaaaccggat gttattactc ttgatgttga aatgccggtc atgaatggga cagatacgct 1624261 ccgcaaaatt attgagattt ataacttgcc ggtcattatg gtgtctagcc agaccgagaa 1624321 aggtaaagaa tgcacaatta attgtttgga gatcggtgcc tttgacttta tcacaaagcc 1624381 atcaggctca atatctctgg atctatacaa aattaaagaa caactagttg agcgtgtcgt 1624441 cgcggcagga ctttccggca agcggaaacg tcctgtttcc cagacagttc ggcccgaacc 1624501 tattgtgcgt gctgtcgtta agcctgaatt aagcaaaccg aaacctggca cgggcagaca 1624561 aattgtgtgt atcggcacat caacaggcgg tccacgggcg ttacaaaagg tgataccgaa 1624621 gctccctaag gatttgaacg caccagtggt tgtcgttcag cacatgcctg aagggtttac 1624681 tgcttctttg gctgatcggc tgaatcattt atctgacatt caggtaaaag aagcaaaaga 1624741 tggtgaagca gctcttaacg gctgtgttta catagcaccg ggcggaaaaa acatatccgt 1624801 tattaaaaac agcgaaggac tccaggttgt gcttgataac catgacacac caagccgtca 1624861 taaaccatct gctgattatt tattccgttc tgtcgggaaa ctgacagatt atgaaaaagt 1624921 agcggttatc atgaccggaa tgggcagtga cggcactgct ggactaaagg acatgctaac 1624981 agccggcaat gtgaaagcca ttgcggagtc tgaagaatct tgtgtcgtat acgggatgcc 1625041 aaaagctgct gttaaagcgg gtctcattca tgagattaaa catgtggaag atatcgcagc 1625101 atccatcaca agctgtgtga aaaaagagag ggtgtgattc aaatggatat gaatcagtat 1625161 ttagatgtct ttattgatga gagtaaagaa catttacaaa catgtaatga aaagcttctt 1625221 cttttagaga aagacccgac tgatcttcag ctcgtacatg atatattcag ggctgcccat 1625281 acattaaaag gaatgagcgc aacgatgggc tacacggatt tagcacatct tacccatctg 1625341 cttgaaaacg tgctggatgc aatccgaaac ggagacatgg aagtcacctc agactggctg 1625401 gatattttgt ttgaagctct ggatcacctg gaaacaatgg ttcagtctat tattgatggc 1625461 ggggatggta aaagagatat ctcagaagtg agtgccaagc ttgatgtgaa tggtgcgcac 1625521 gctgaatccg ctgcctccgc tgaacctgca gaagcacaga gttcagcatc tgattgggaa 1625581 tatgatgaat ttgaacgcac agttatacaa gaagcggagg agcaaggctt caaacgatat 1625641 gaaatcaaga tttctctgaa cgaaaactgt atgttaaaag cagttcgtgt ctatatggtg 1625701 tttgaaaaac taaatgaagt cggagaagta gccaaaacaa ttccaagtgc tgaagtgctt 1625761 gaaacagaag attttggaac tgactttcaa gtttgtttct taacacatca atcagcggaa 1625821 gacattgaac aattaatcaa tggcgtgtcg gaaattgagc atgttgaagt cattcaaggg 1625881 gctcctttaa catcagctga aaagcctgaa gaatctaagc aagaagattc accagcagca 1625941 gctgtacctg cgaagcagga gaaacaaaaa cagcctgcta aaaacgatga acaggcgaag 1626001 cattcagccg gcggatctaa aacaattcgt gtcaacattg acaggcttga ttctttaatg 1626061 aacttatttg aagagcttgt cattgaccgc gggcgtctcg agcagattgc gaaagagctt 1626121 gagcataatg aactgactga aacggttgaa cgaatgacga gaatttccgg agatttgcaa 1626181 tcgattattc tgaatatgag aatggtcccg gttgaaactg tttttaacag attcccgaga 1626241 atgattcgcc agcttcagaa agagctgaat aaaaaaattg aactctcgat catcggtgcg 1626301 gaaactgaac tggatcgtac agtaattgat gaaatcggag atccactcgt tcacttgatc 1626361 agaaacagta ttgaccatgg tatcgaggcg ccggaaacac gtttgcaaaa gggaaaaccg 1626421 gaatcaggaa aagttgtgct taaagcttat cacagcggca accatgtctt tatcgaagta 1626481 gaggatgacg gcgcaggcct taatcgaaaa aaaattctgg aaaaagcgct tgagcgcggg 1626541 gtcataacgg aaaaagaagc tgaaacctta gaagacaacc aaatttacga attgattttt 1626601 gctccggggt tctcaactgc tgaccaaatt tctgatattt ccggccgcgg tgtaggactt 1626661 gacgttgtaa aaaacaaact ggagtctctt ggcggttcag tcagtgtgaa atcagccgag 1626721 ggtcaaggct ctctattcag catccagctg ccgcttacct tgtctattat ttcagttctg 1626781 ctgattaagt tggaagaaga gacatttgcc attccgattt cttcaatcat tgagacagca 1626841 gttattgaca gaaaagacat tttgcaaacg catgaccgtg aagtgattga ctttagaggg 1626901 catattgtcc ctgtcgttta tttaaaagaa gagtttaaaa tagaagatac aagaaaagat 1626961 gcggaacagc tccatatcat tgtcgtgaaa aaaggcgaca aacctactgc atttgtggtg 1627021 gactccttta ttggccagca ggaagttgtg ctgaaatcac tcggagatta tttaacaaac 1627081 gtctttgcaa tttccggagc tactatttta ggagacggag aagtagcgct cattattgat 1627141 tgtaatgcac tgattattta accattcgag gaggtgtctc acatgactgc agaaattaaa 1627201 acaggcgaaa aaatgatagt ctttatggta aatggcaaag aatatgccat ttccgtcact 1627261 caggtgaaat caattgaaaa atggcaaaag ccaacgaggg tacctggcgt cgaaccatat 1627321 atttgcgggg taatcaattt acgcggggtg gtgactccgg ttattgattt aagaaaacgc 1627381 ctgaatttgc cagagtatga aattacagat gaaacacgaa ttatcattat tgcttatcgt 1627441 gatattgaag tcggctggat tgtggatgaa gcgaatgatg tgattaccgt acacgaaagt 1627501 gaaatagaat ctgctccaga aggcgttcag aaagatacgg atgtgtcgat cgaacagatt 1627561 gtgaaacaag agaacagact cttaaatatt attgatgcga acgcggtttt ggataaagaa 1627621 tcatctcagt ccgctgtgcc cgatcaagct taatcttaaa ggggttatga catgagtatt 1627681 tttaatggaa tcaaagaaga gcagatggac attttgcggg aagtcggcaa tataggcgcc 1627741 ggccactccg cctctgcaat ggcccagctg ttaaatagaa agatagatat ggaagtccca 1627801 tttgcaaagc tgctgtcttt tgatgagctt gttgattttt tcggcggcgc cgatgtcccg 1627861 gttgccagca tctttttaag aatggaaggc gatttaacgg gttcaatgtt ctttataatg 1627921 cctttttttc aggcggagca gtttatcaga gagctgattg gaaaccccga ttttgacata 1627981 gaggacttag gtgaagacca catgagctca tccgctttgc atgaactggg caatatttta 1628041 gcggggtcat atttaacagc tttggcggat ttgacgaaac tccagctcta tccaagtgtt 1628101 cctgaagtct cattggacat gttcggagct gtgatcagcg aagggctgat ggagctcagt 1628161 caggttggag aacacgccat tgttgtcgac acgtcaattt ttgaccaaag ccatcagcag 1628221 gagctgaaag cgcatatgtt tatgctgccg gactatgatt catttgaaaa gctctttgtc 1628281 gccttaggtg catcattatg agtacaactg aggctgttgt tataaaggtt gggattgctg 1628341 acgtgaagat cgcccgcttc ccggatacca tccggacctc tggtttgggc tcatgtgtgg 1628401 ggctggtgct ttatgataaa gaaaagcaaa cggcgggtct tgttcatgtc atgcttccgg 1628461 attcgacgtt atcgaaaact gccgagctca accgggctaa gtacgctgac accgccgtac 1628521 agaccacgat tgatatgctg atagaagcgg gatgccggaa atttgcatta aaagcaaagc 1628581 tggccggcgg atcagagatg tttaaattta aatcgacaaa tgatttgatg aagatcggac 1628641 cgagaaatgt attagcgata aaagaacagc tgtctttatt taatattcct attattagtg 1628701 aagatacggg cggctcaagc ggccggacga tagaatttga accgaagtcc tgcatgctgc 1628761 atattcgaac tgttaaacaa ggtgaaaaaa cgatttaatt aaggtattag ggggataaca 1628821 atgcaatcct tgaattatga agatcaggtg ctttggacgc gctggaaaga gtggaaagat 1628881 cctaaagccg gtgacgactt aatgcgccgt tacatgccgc ttgtcacata tcatgtaggc 1628941 agaatttctg tcggactgcc gaaatcagtg cataaagacg atcttatgag ccttggtatg 1629001 cttggtttat atgatgccct tgaaaaattt gaccccagcc gggacttaaa atttgatacc 1629061 tacgcctcgt ttagaattcg cggcgcaatc atagacgggc ttcgtaaaga agattggctg 1629121 cccagaacct cgcgcgaaaa aacaaaaaag gttgaagcag caattgaaaa gcttgaacag 1629181 cggtatcttc ggaatgtatc gcccgcggaa attgcagagg aactcggaat gacggtacag 1629241 gatgtcgtgt caacaatgaa tgaaggtttt tttgcaaatc tgctgtcaat tgatgaaaag 1629301 ctccatgatc aagatgacgg ggaaaacatt caagtcatga tcagagatga caaaaatgtt 1629361 ccgcctgaag aaaagattat gaaggatgaa ctgattgcac agcttgcgga aaaaattcac 1629421 gaactctctg aaaaagaaca gctggttgtc agtttgttct acaaagagga gttgacactg 1629481 acagaaatcg gacaagtatt aaatctttct acgtcccgca tatctcagat ccattcaaag 1629541 gcattattta aattaaagaa tctgctggaa aaagtgatac aataatgaat ttcatggtta 1629601 gcgagtgaaa aacatgtcaa cactattatg gcttttaagc tttatgctcc acggcgttct 1629661 tctgtacgct gtcattatcc tgtatacgag gctcgctgca gtgaaagaaa cagaaaaaca 1629721 gcaaaaacag atacttgaag agacggaaaa caccttggcg gcatttctgc ttgaattaaa 1629781 agaagaaaat gagaaactga tagaaaataa agcttcatct gcaagtcaat cagatgaaga 1629841 atcccaaaag tcaggccttc agacctctga aacatatcaa gagcgggatc cagtccaaga 1629901 ggcagagaat cttcctgaac atattgaagg tctgattaca gaggttgacc gtcgggaaga 1629961 gctcgtaaac agtgaggtcc aatcatttga agaccaggtc atagaattat atgaacaggg 1630021 atattcggca agtcaaattg cccagaaaat gaagagcgga aagacagaaa tcgagctatt 1630081 tttaaaattt cgctccaaag gtgtaaagga ttcttgattg tcggataaag ctgtgttata 1630141 ttatgtcttg gtgttaaata cacacgctta acgatttatg cagagggtgc tgcaggcggc 1630201 agttctgtac aaaaatgacc taagcggagg aaaaaaacca ttatattagg aggaaataac 1630261 atgtcagtca tttctatgaa gcaattgctt gaagctggtg ttcacttcgg tcaccaaaca 1630321 cgccgttgga acccaaaaat gaagcgttac attttcacgg agcgtaacgg aatctacatc 1630381 attgaccttc aaaaaacagt caaaaaagta gaggaagctt acaacttcac taaaaatctt 1630441 gctgctgaag gcggaaaaat ccttttcgtc ggaacaaaaa aacaagctca agattctgtt 1630501 aaagaagaag ctcaacgctc tggcatgtac tatgtcaacc aacgctggtt gggcggtaca 1630561 ttaacaaact tcgaaacaat ccaaaaacgt attaaacgtc ttaaagacat tgaaaaaatg 1630621 caagaaaacg gtacgtttga tgtacttcct aaaaaagaag tcgttcaatt gaaaaaagaa 1630681 ttagagcgtc ttgaaaaatt cctaggcgga attaaagata tgaaggatct tcctgatgca 1630741 ttattcatca tcgatcctcg caaagagcgc atcgctgttg cggaagctcg caaattaaac 1630801 atccctatca tcggtatcgt agatactaac tgtgatccag atgaaatcga tgttgttatc 1630861 ccagcgaacg atgacgctat ccgcgctgtt aaacttctaa cttctaaaat ggcagatgca 1630921 atcttagaag cgaagcaagg cgaagaagaa gcggaagttg ctgaagaaac tgcaccagaa 1630981 acagaaacaa caactgcgta acctattcaa aaggtgataa gagggactgc cttttatcac 1631041 cttttttcaa gaaaaatgtg taatatacat actcttgttt aaacatataa ggaggaatac 1631101 aaatggcaat tactgcacag caagtaaaag aactgcgtga aaaaactggc gcgggcatga 1631161 tggattgtaa aaaagcgtta actgaaactg acggagatat ggacaaagca attgaccttt 1631221 taagagaaaa aggaattgca aaagcagcga aaaaagctga ccgtatcgca gcagaaggtt 1631281 ctactcttat taaaactgac ggcaacaaag gcgttatcct agaagtaaac tctgaaactg 1631341 atttcgttgc gaaaaacgaa ggttttaaag agcttcttaa cactttagct gaccaccttc 1631401 ttgcaaacac gccagctgat gttgaagaag caatgggcca aaaaatggaa aatggctcaa 1631461 ctgttgaaga gtacatcaca agcgcagttg ctaaaatcgg tgagaaaatc actcttcgcc 1631521 gctttacagt tcttacaaaa gacgacagct ctgcattcgg tgcgtacctt cacatgggcg 1631581 gccgcatcgg tgtattaact gttctcaacg gtacaactga tgaagaaact gcgaaagata 1631641 tcgcaatgca cgttgctgca gttaaccctc gttacatttc tcgtgatcaa gtatctgaag 1631701 aagaaacaaa tcatgagcgt caaatcttaa ctcagcaagc cctccaagaa ggcaaacctg 1631761 aaaacatcgt agcgaaaatg gttgaaggcc gtctgaacaa attcttcgaa gaaatttgtc 1631821 tattagacca agcgttcgtt aaaaacccag atgaaaaagt gaaacaagtt attgcagcga 1631881 aaaacgctac tgttcaaact tttgtccgct atgaagttgg agaaggcatc gaaaaacgtc 1631941 aagaaaactt tgctgaagaa gtaatgaacc aagtgaaaaa ataatggtga aaagatttcg 1632001 cggctaagtc gcgtcttttc aggcagtata ggggacacat tttgtgttcc ctatttttaa 1632061 aactatattt acaaaccttt ttttctcttg cataatagaa aacggcaatg tttacacttg 1632121 gaggttatca tggaaaaacc aaaatacaaa cgtatcgtat taaagcttag cggggaagca 1632181 ttggcaggag aacagggaaa tggaattaac ccgactgtca ttcaatccat tgcaaagcaa 1632241 gtgaaggaaa tcgctgagct tgaagtcgaa gtggctgttg ttgtaggcgg cggcaactta 1632301 tggcgcggaa aaacaggaag tgacctgggc atggaccgcg cgactgctga ctatatggga 1632361 atgctggcga cagtaatgaa ttcgcttgct cttcaagaca gcttggaaac actcggaatc 1632421 cagtccagag tgcaaacatc cattgaaatg agacaagttg ctgaaccgta cataagaaga 1632481 aaagcgatac gccacttaga gaaaaaacgt gtcgttattt tcgctgcggg cacaggaaac 1632541 ccatatttct caactgatac gacagctgca ctgcgggctg ctgaaattga ggcagacgtt 1632601 attttaatgg ctaaaaataa cgttgacggt gtgtataatg ctgatcctag aaaagatgaa 1632661 tcagctgtta agtatgaatc actttcttat cttgacgttc ttaaagacgg cctggaagtc 1632721 atggattcaa cagcttcctc tttatgcatg gacaatgaca ttccgcttat cgtcttttct 1632781 attatggaag aaggaaatat caaacgtgcc gttatcggtg aatcaatcgg aacgatcgtg 1632841 agggggaaat aacgtgtcaa aagaagtatt aactcaaaca aaagaaaaaa tggaaaaagc 1632901 aattgctgct tatcagcgcg aattggctac tgtacgcgca ggccgtgcaa atccatcatt 1632961 attagataaa gtaacggttg aatattacgg agcgcagaca cctttaaatc agttgtcttc 1633021 tattaacgtg cctgaagctc gtatgctcgt tatcacgcca tacgataaaa cagcaatcgg 1633081 tgatatcgaa aaagcgattt taaaagctga tttaggtctt acaccaacaa gtgacggcaa 1633141 tatgattcga attgcaattc cggcactaac agaagagaga cggaaagaat tagtgaaagt 1633201 tgtaaaaaaa tatgctgaag aagcaaaagt agctgttcgt aacgttcgcc gtgatgctaa 1633261 cgatgatctc aaaaaacttg agaaaaacgg agacattact gaggatgaac tgcgtgcttc 1633321 cactgaagac gttcaaaaac tgacagatga atatgtgtca aaaattgaca gtgtcacaaa 1633381 agacaaagaa aaagaaatca tggaagttta atgaaaaact atgtacaata gataatagtg 1633441 aaaagaccct ctcatgttta cagggggttt ttttgttaat actgttgatt acattgatta 1633501 tcagcaggga atgtaacctt tttgggtgac ggaggaatct catgctcaac atactcaaaa 1633561 attggaagaa tcagcaaact gcggcttcca acttagaacg ttatacaaaa gaagacatac 1633621 ttaagggaga aattcccgaa cacatcgcca ttatcatgga tggaaatggc cgttgggcta 1633681 aaaaacgctc tcttcccaga attgcaggcc accatgaagg gatgaaggtg gtaaaaagga 1633741 ccacgaagct cgcaaacgaa ttaggtgtca aagtactgac attgtatgca ttttcaacag 1633801 aaaactggaa aagaccgaaa atggaggtcg attttttaat gaagcttccg gaagaatttt 1633861 tgaatacgta tcttccagag cttgttgagg aaaatgtaca ggttcggatc attggggatg 1633921 aaacggcttt gccggcgcac acattacgtg cgattgaaaa agctgtacag gacacggcgc 1633981 aaaacgacgg aatgatcctt aattttgctc ttaactatgg aggccgtact gaaattgtca 1634041 gtgctgcaaa atcactcgcg gaaaaagtga aggaaggctc tttgaatatt gaagacattg 1634101 atgaatcgct tttttctact tatttgatga ctgaatcttt gcaggatcct gaacttttaa 1634161 ttcgaacgag cggcgagata aggctgagta attttatgct atggcaggtt gcctacagtg 1634221 aatttgtctt tactgacgtc ttgtggcctg actttaaaga agatcacttc ttgcaggcgt 1634281 taggagagtt tcagcagaga ggccggaggt ttggcggaat ttagaggatg gtggacatga 1634341 aacaaagaat tttgacaggt gttctggcag caattgtatt tttatttttg gttattgtcg 1634401 ggaaattgcc gttcaccata ttaatttatg ctatgggcag tgtggcgctt tttgaacttt 1634461 tacggatgaa aaagctgaag ctggtttcac tgccgggttt gatcggtctt ttattattgt 1634521 ggatgttctt attaccaagc cagtattcgt tttttgaagc ggacgggatt tccaaaatgg 1634581 aaatcgcttt atttgcggta ctgctattgc tgacttacac agtgttggtc aagaacacct 1634641 ttacttttga tgaagtcggg tttattacgc ttgcagcaat ttacatcgga atgtgttttc 1634701 attattttat cgaaatcaga aatcttgacc aatacggatt aacatacatt ttttatgcgt 1634761 gtgttgtcat ttggtccacc gattccggtg cctattttgt cggtaaatcg cttgggaagc 1634821 ggaaactgtg gcctgaaatc agtccgaata aaacagtgga agggtttgca ggcggaattg 1634881 tcatcgcact tgtattggcg acgatttttc agcttgttgc acaacttccg atcccgtata 1634941 tctatctgct gttgatcacg ctgtttttgt ctgtttttgg acaactggga gatttagtgg 1635001 aatccgcctt gaaaagacat tacgatgtaa aggattctgg gaatattctt cccgggcatg 1635061 gcggtatatt agaccgtttt gacagtttct tgtttgtcat gcctttcttg tactttctgc 1635121 ttgccctttt ttcataaaaa agtctaatat gaatatgaga ctgatcatgc agcaataaga 1635181 ataggagtag tggcaacttt gaaaaatatt tgtcttttag gagcaacagg atcaatcggc 1635241 gaacagactc ttgatgtact gcgtgcacat caagaccaat ttcagctggt atctatgtcg 1635301 tttggcagaa atattgataa ggccgttcca atgattgagg tctttcagcc gaagtttgtc 1635361 tctgtcggtg atctggatac atatcataaa ttaaaacaaa tgtctttttc ttttgaatgc 1635421 caaatcgggc tgggagaaga aggactgata gaagcagcag tgatggagga ggttgacatt 1635481 gttgtcaacg ctttgcttgg aagcgtcggt cttatcccga cattaaaggc aattgaacag 1635541 aaaaaaacaa ttgcgcttgc aaataaggaa actcttgtca ctgcagggca tatagtaaaa 1635601 gaacatgcta agaaatatga tgttccgctg ctgcctgttg acagtgagca ttcagccatt 1635661 tttcaagctc ttcaaggcga acaggctaaa aacattgaac gcctcatcat tacggcatcc 1635721 ggcggaagtt ttcgggacaa gacgcgggag gagctcgaat cagtaacggt tgaagatgca 1635781 ttaaaacatc caaactggtc aatgggtgca aaaattacaa ttgattcggc tacaatgatg 1635841 aataagggat tagaggtgat cgaggcacac tggcttttcg atatacctta tgaacaaatt 1635901 gatgtggttt tacataagga gagcatcatc cattcaatgg ttgagttcca tgataaaagt 1635961 gtgatcgcac agctcggaac tccggatatg agagtcccca ttcaatatgc gctcacttat 1636021 cctgaccgat tgccattacc agatgcgaaa aggcttgaat tatgggaaat cggcagcctt 1636081 cattttgaga aagctgattt tgacaggttc cgatgcttac aatttgcttt tgaatcaggt 1636141 aaaataggag gaacaatgcc gacagtgcta aatgcggcaa acgaagtagc tgtcgctgcc 1636201 tttttagctg gcaagatacc gtttttggct attgaagact gtatcgaaaa ggcactaacc 1636261 cgccatcaat tactgaaaaa accgagcctg gcggacattc aagaagtgga caaagatacc 1636321 cggggatacg tcaattcaat actcacataa ggtggtatgt tcgtgaatac agttatagcg 1636381 tttatcatta ttttcggaac gctcgttttc ttccatgaac tgggccattt attgctagcc 1636441 caaagagcgg gaattctctg ccgtgaattt gcgatcggct tcggtccaaa gattttttct 1636501 ttcaaaaaaa atgaaacagt ttatacgatc aggctgcttc cggtcggcgg atttgttcgt 1636561 atggccggcg aagatccgga aatgattgag gtgaaacccg gatacacggt cgggcttctg 1636621 tttaataagg aagatcaagt tgagaaagtc atcatcaatc aaaaggaaaa atatccggat 1636681 gctttagtca ttgaagtgga aacagcggat ctagagcatg acatgaagat caccggttat 1636741 gaacagggga aagaggacga actttccagc tttactgtca gcgaaacatc cttttttatt 1636801 gtagacggag aagaagtgca gattgcgccg tataatcgcc aatttggttc caaacctgta 1636861 tggcagcgga ttaaagcaat tgctgcaggg ccgattatga actttatttt agcttacgtc 1636921 attttagtga tgcttgggct gattcaaggc gtaccgtcaa atgaacctat gctcgggcag 1636981 ctgacagaca atggacgggc ggctgaagca gggctaaaag aaggggatta tatccaaagc 1637041 attaacggag agaaaatgag gtcttggact gacattgtct ccgctgtaaa agaaaacccg 1637101 gagaaagaaa tggacgttgc agtaaaaaga gataacaaaa cgcttcatat ttcggtgact 1637161 ccggaagctg ttaaagatga gaacaaaaaa acaatcggac gtttcggttc ctatgcgccg 1637221 actgaaaaag gcgtactctc agcggttgct tacggcgcga catcaacagt tgatgtcacc 1637281 aaagccattt taaccaatct gagcaaatta gtaacaggcc aatttaaact cgatatgctg 1637341 tcaggtcctg tcggcatata tgacatgaca gaccaagtgg cgaaaacagg gatcgtgaac 1637401 ttatttcagt ttgcggcgtt tttaagcatt aaccttggga ttgtcaacct gcttccgatt 1637461 ccggcacttg acggaggaag actgttgttt ctatttattg aagcgattcg gggcaaaccg 1637521 attaacaggg aaaaagaagc atttgttgtg tttatcggag tagctttctt aatgcttctt 1637581 atgctggttg tcacatggaa cgatatccag cggctgtttt tgtaaacgaa aagtaaatca 1637641 atcagaggtg cgaagaaatg agacaaagct tgacgcttat tcctacgctc cgtgaagttc 1637701 cagctgatgc cgaagcaaaa agtcatcagc ttcttctgag agcaggattt atcagacaga 1637761 atacgagcgg ggtatacagc tatatgcctc ttgcgtataa ggtgattcaa aacattcagc 1637821 agattgttcg agaggaaatg gagaaaattg atgccgtaga aatgctcatg cccgcattgc 1637881 agcaggcaga gacatggcag gaatcaggca gatggtatac gtatggtccc gaactgatga 1637941 gactaaaaga ccgtcatggc cgtgaatttg ctttaggggc aacgcatgaa gaggttatca 1638001 cttcgcttgt tcgcgatgag gttaaatctt ataagcgtct ccctctgact ctttatcaaa 1638061 ttcagtctaa gttcagagat gaaaaacgtc ctcgcttcgg tttgttaaga ggccgcgaat 1638121 ttattatgaa ggatgcgtac tctttccatg catctgcaga gagcctggat gaaacgtatc 1638181 aaaaaatgta cgaggcctat tctaatattt ttgcccgctg cggcattaat gtaagacctg 1638241 ttatcgctga ttcaggcgca atgggaggaa aggatacgca cgaatttatg gcactttctg 1638301 cgatcggaga ggatacgatt gcgtattctg atgaatcaca gtacgcggct aatatcgaga 1638361 tggctgaagt tcttcaccag gaagttcctt cagatgaaga gcctaaagct ctagagaagg 1638421 ttcatacgcc taacgtgaaa acaatcgaag aactgactgc gttcttacag gtttcggctg 1638481 aagcgtgcat taagtcagta ttgtttaaag ctgatgaccg ttttgtctta gtgcttgtaa 1638541 gaggggatca tgaagttaac gatattaaag tgaaaaactt gcttcatgca gaagttgtag 1638601 agcttgctac acatgaagag gtcattcagc agctcggaac agagccaggc tttgtaggcc 1638661 ctgtcggtat tcatcaggat gtggaagtat atgccgatca agctgtgaaa gcaatggtta 1638721 atgctgttgc cggggcaaat gaaggagatc atcattataa aaatgtcaat gtgaatcgtg 1638781 acgcgcaaat taaagaattt gctgatcttc gttttattaa agaaggtgat ccttcaccag 1638841 acggcaaggg aacgatccgt tttgctgagg gaatcgaagt cggacaagtc tttaagctcg 1638901 gaacacgcta ttcagaagcg atgaatgcga catatttaga tgaaaacgga cgcgcgcagc 1638961 caatgctgat gggctgttac ggaatcggtg tgtcaagaac gctttctgct attgctgaac 1639021 agcatcacga cgaaaaaggc ttaatatggc caaaaagcgt tgcgccgtac gatcttcata 1639081 ttcttgcttt gaacatgaaa aacgatgggc aaagagagct tgctgaaaag ctgtatgccg 1639141 atttaaaagc ggaaggctat gaagtgctct atgatgaccg tgctgagcgt gccggcgtaa 1639201 aattcgctga ttcagattta atcggccttc caatccgcat cactgtcgga aaacgagctg 1639261 acgaaggaat cgtcgaagtg aaaattcgtc aaactggtga gtcaactgag atttcagtag 1639321 acgaattatc tgcgtttatc agcaagcagt aatcaccata acgatttatc aaaaaacatg 1639381 ttaaaataga aataatagaa ggtacctcat tgcctgaggt accttcactt atgatgtttt 1639441 tagggaggga tactgtctta atggaacagt tatcagtaaa cagaaggcag tttcaaattc 1639501 ttctgcagca gattaatatg acagatgata ccttcatgac atactttgaa catggcgaga 1639561 ttaaaaagct gacaattcac aaagcttcta agtcttggca ttttcatttt caatttaaat 1639621 ctttgctgcc ttttcaaata tatgacacat taacaacgag gctgacgcaa tcgtttgccc 1639681 acatagcaaa agtgacatct tcaattgaag ttcaggatgc cgaggtcagt gaaagtatcg 1639741 ttcaagacta ctggtcacgc tgcattgaag aactgcaggg catttcgccg ccgattatca 1639801 gtcttttaaa ccagcaaaaa ccgaagctga agggcaataa actgattgtc aaaaccaaaa 1639861 cagatacaga agcggctgcg ctaaagaaca aatacagttc catgattcaa gcagaatacc 1639921 gtcaatttgg ctttccggat cttcagcttg atgctgaaat atttgtatcc gagcaagaag 1639981 ttcaaaagtt tcgggagcaa aagcttgcgg aagaccaaga gcgggctatg caggccttga 1640041 ttgaaatgga gaagaaagat aaagaaagtg atgaagacca agcaccatct ggtcctcttg 1640101 ttatcggtta tcaaattaaa gataacgagg aaatccgaac acttgacagc atcatggacg 1640161 aagaacggag aattacggtc caaggttatg tgtttgatgt ggagacgcgc gagctgaaga 1640221 gcgggcgcac gctgtgtatc ttcaaaatta cagactatac aaatagtatt ttgatcaaaa 1640281 tgtttgcacg tgaaaaagaa gatgcggcgc tgatgaagtc tctgaaaaaa ggaatgtggg 1640341 taaaagcacg cggaagcatt caaaatgata catttgtcag agaccttgtc atgatcgcaa 1640401 atgacgtaaa cgaaataaaa gcaaaaaccc gtgaagattc agcacctgaa ggagaaaaaa 1640461 gagtggaatt gcatcttcat tccccaatga gccaaatgga tgctgttacg ggtatcggaa 1640521 agcttgtcga acaggcgaaa aaatgggggc atgaggccat cgctttgacc gaccatgctg 1640581 tcgttcaatc cttccctgat gcgtattctg cggccaaaaa gcatggaatt aaaatgattt 1640641 acgggatgga agcgaatctc gtggatgatg gcgtgccaat tgcttataat gccgcacatc 1640701 gtctgctcga agaagaaaca tatgttgttt ttgacgttga gacgacagga ttgtctgctg 1640761 tatacgatac cattattgag ctggctgcag taaaagtaaa aggcggagaa attattgata 1640821 aatttgaggc gtttgcgaac ccgcatcgtc cgctttccgc cacaatcata gagctgacag 1640881 ggatcacaga tgatatgcta caagacgctc cggatgtcgt agatgtaata agagatttca 1640941 gagaatggat tggcgatgat attcttgtcg ctcataatgc aagctttgat atgggattct 1641001 taaatgtagc ctataaaaaa cttcttgaag tcgaaaaagc taaaaaccca gtcattgata 1641061 cgcttgaact tggacgtttt ctctatccgg aatttaagaa ccaccggttg aacacacttt 1641121 gtaaaaagtt tgatatcgag ctcacacagc atcaccgtgc gatctatgat actgaggcaa 1641181 ccgcttattt gcttctgaaa atgctgaaag acgcagctga aaaaggtatt cagtaccatg 1641241 atgagttgaa tgaaaatatg ggtcagtcca atgcttatca aagatcaaga ccgtatcatg 1641301 caacattact tgccgtgaac agcacgggac ttaaaaattt atttaagctt gtgtcacttt 1641361 ctcatattca ttatttttac agagtgccgc gtattccgag atctcagctt gagaaataca 1641421 gggaagggct tctgatcggt tctgcttgtg acaggggaga ggtttttgag ggaatgatgc 1641481 aaaaatcgcc tgaagaggtg gaagatatcg cgtcattcta tgattacctt gaggttcagc 1641541 cgcctgaagt gtatcgtcac ttgctggagc ttgaactggt ccgtgatgaa aaagcgctga 1641601 aagaaattat tgcgaatatc acgaagctgg gggaaaagct taataaaccg gttgttgcta 1641661 cgggaaatgt tcattacttg aatgatgagg ataaaatcta cagaaagatt ttaatatcct 1641721 cacaaggcgg ggcaaatccg ctgaataggc atgaactgcc gaaagtgcat ttcagaacga 1641781 cagacgaaat gcttgaagct ttttctttct taggtgaaga aaaagcgaag gagatcgtag 1641841 tcaccaatac ccaaaaggtt gcttctttag ttgatgacat caagccgatt aaagatgatt 1641901 tatatacgcc gaaaatcgaa ggcgctgatg aagagatcag agaaatgagc tatcagcgtg 1641961 caagaagcat ttacggggaa gagctgcctg aaattgtcga agcgcggatt gaaaaagagt 1642021 taaagagtat tattggccac ggatttgctg ttatttactt gatctctcac aaacttgtaa 1642081 aacgttcact agatgacggg tatctcgttg gttcccgtgg ttccgtagga tcttcattag 1642141 ttgcgacact tactgagatt actgaggtaa acccgctgcc gccgcactat gtttgtcctg 1642201 agtgccagca ttctgagttc tttaatgacg gttctgtcgg ttctggtttt gacctgcctg 1642261 acaagacatg ccctcattgc ggaacgcctt tgaaaaaaga cggccatgat attccatttg 1642321 aaacgttctt aggatttaaa ggggacaaag tacctgatat cgatttgaac ttctcagggg 1642381 aatatcagcc gcaagcacac aattacacaa aagtattgtt cggagaagac aatgtatatc 1642441 gtgcgggaac aataggcacg gtggcagaaa aaacagccta cggttatgta aaaggctatg 1642501 ccggagacaa caatcttcat atgcgcggtg ccgaaataga tcggctcgta cagggatgca 1642561 caggtgtaaa acgtacaact ggacagcacc ctggcggtat tatcgtagtt ccggattata 1642621 tggatattta tgatttttca ccgatccagt tcccggcaga tgccacaggt tcagagtgga 1642681 aaacgactca ttttgatttc cactccatcc atgacaacct gttaaaactt gatattctcg 1642741 gacacgatga cccgactgtt attcggatgc ttcaagactt aagcggaata gatccgaaaa 1642801 caattccgac ggatgatcct gaagtgatga agatcttcca gggaaccgaa tcactcggtg 1642861 tgactgaaga acagattggc tgtaaaacgg gcactcttgg aattcctgaa ttcggaaccc 1642921 gatttgtccg gcagatgctt gaagatacaa agccgaccac tttttctgag ctcgttcaga 1642981 tttcaggctt gtctcacgga actgatgtat ggcttggcaa tgcacaggag ctcatccaca 1643041 ataatatttg tgagctgagt gaggttatcg gctgccgtga tgacattatg gtttatttaa 1643101 tctatcaagg ccttgagccg tcccttgcct ttaaaatcat ggaattcgtg cgtaaaggaa 1643161 aaggattaac gcctgaatgg gaagaagaaa tgaaaaataa caatgtccca gactggtata 1643221 ttgattcctg taaaaagatt aaatacatgt tcccgaaagc ccacgccgcg gcatatgtct 1643281 taatggcagt ccgcattgct tactttaaag tgcatcatgc tcttttgtat tatgcggctt 1643341 attttaccgt tcgtgcagat gactttgata ttgatacaat gatcaagggc tctacagcaa 1643401 tcagagcggt aatggaggat ataaacgcta aaggacttga tgcttcaccg aaggaaaaga 1643461 accttctgac tgttttagaa ttagcgcttg agatgtgtga gagaggctat tcattccaaa 1643521 aagtcgattt atatcgctcc agcgccacag agtttattat tgacggcaac agtcttattc 1643581 cgccgtttaa ctctattcca gggttaggga cgaacgctgc tttgaacatt gtaaaagctc 1643641 gcgaagaagg cgaattcctc tcaaaagaag atttgcaaaa gagagggaaa gtatcaaaaa 1643701 cgattttaga gtacttagat cgccatggct gtctggagtc actgcctgat caaaaccaat 1643761 tgtcactgtt ctaatatgga aagcagaatt tctcagaaat tctgcttcta tgcatacata 1643821 agcgcaaaaa gtgccatcgt aatattagag tttctgtcac ttgcttaggt atgaaggtaa 1643881 gcgtatatcc atttgcaata aaaatatggt tatggtatag ttttattgga aatgctaacg 1643941 attaccgagg caaagagtgg ggaaacccgc tcttttgtat tgaacaggag aattttgtct 1644001 cgacatgttc atcgtttact ttttagcccc tgctcttttg aagcagggtt tttatgcaga 1644061 gtgacgagac gaatatgaga tcgacagcac aaggaggaag aacatgagca aaaaagtgac 1644121 tgacaccgtt caagaaatgg ctcagccaat cgtagacagc cttcagctgg aactcgttga 1644181 cattgaattt gtcaaagagg gccaaagctg gttccttcgc gtgtttattg attccgatga 1644241 cggtgtggat attgaggaat gtgccaaagt aagcgaagct ttaagcgaaa agcttgatga 1644301 ggcagaccca atcagccaaa attactttct tgaagtctca tctccaggag ctgagcgtcc 1644361 gctaaagaaa aaagccgatt tcgaaaaatc actaggaaaa aacgtataca ttaagacgta 1644421 tgagcctatt gacggcgtaa aagtgtttga aggtgaactg gctgaatttg atggacaaac 1644481 agtgacagtt gagatcacga tcaaaacaag aaagaaacgg atcaatattc cgtatgaaaa 1644541 gatagctaat gcaagattag ctgttacatt ctaatgaata caaatgtttt aaggggggag 1644601 accgttaaat gagcagtgaa ttattagatg ctctcacgat tcttgaaaaa gaaaaaggca 1644661 tcagtaaaga aattatcatc gaagcaatcg aagctgcgtt aatttctgct tataagcgga 1644721 attttaatca agcgcaaaat gtacgggtgg atctaaaccg tgaaactggc tccatccgtg 1644781 tatttgcaag aaaagatgtc gttgacgaag tatacgacca gagattagaa atctcaattg 1644841 aagaggcaca gggcatccat ccggaatata tggtcggcga tgtcgtcgaa atcgaagtta 1644901 cacctaagga tttcgggcgc atagctgctc aaacagcgaa gcaggtcgtc acacagcgtg 1644961 tgcgcgaagc tgagcgcggt gtgatttatt ctgaatttat cgaccgtgaa gaagacatca 1645021 tgacagggat cgtccagcgt ctggacaata aatttatcta cgtgtcttta ggcaaaatag 1645081 aagccttgct gccggttaat gagcaaatgc cgaatgaaag ctacaagccc catgaccgca 1645141 ttaaggtata tatcacaaaa gtagaaaaaa caacgaaggg tccgcagatt tatgtgtcaa 1645201 gaacacatcc aggcctgtta aagcgtttgt ttgaaattga agtgcctgaa atttatgatg 1645261 gaactgtcga gctaaaatct gttgccagag aagccggcga ccgttcgaaa atttctgttc 1645321 gcacagatga tcctgacgtt gatcctgtcg gttcatgcgt agggcctaaa ggccagcgtg 1645381 tgcaagcaat cgtcaatgaa ttaaaaggtg aaaaaattga cattgtcaac tggtccagtg 1645441 atcctgtaga atttgtcgcg aatgcgctca gcccttccaa agtgcttgat gtcattgtta 1645501 atgaagaaga aaaagcgaca actgttattg ttcctgatta ccagctgtct ctggcaattg 1645561 gaaaaagagg acaaaacgca cgcttagctg ctaaactgac aggctggaag attgatatta 1645621 agagcgaaac ggacgcaaga gaacttggaa tctatccgag agaacttgaa gaagatgatg 1645681 agccgctctt tacggagcct gaaactgctg aatcggatga ataagaggtg actttaggtg 1645741 aataaacaca aaaagatccc attacgcaaa tgtgtagtga ctggtgaaat gaagcctaaa 1645801 aaggaactga tccgagttgt acggtcgaaa gaaggcgaaa tctcagtaga cccgaccgga 1645861 aaaaagaatg ggcggggtgc ttatttaacg ctggataaag agtgcatctt agcagcaaaa 1645921 aagaaaaaca ctttgcaaaa tcaatttcaa tcacaaatcg atgaccagat tttcgatgaa 1645981 ttgctggaac tggcggaaaa ggtgaaaaaa taaaatgtct ggaatggaat ggtttccctt 1646041 gctgggtctg gccaatcgag ctcgtaaggt cgtgtcaggc gaagacttgg taataaaaga 1646101 aatcaggaat gcgcgtgcaa agcttgtcct gcttacagag gatgcatcat ctaacacagc 1646161 aaaaaaagta actgacaagt gcaattatta taaagtccct tataaaaaag tcgagagtcg 1646221 cgcggttctt ggacgctcta tcggtaaaga agcccgtgtc gttgtcgccg tcactgacca 1646281 aggttttgcg aataagctga tcagcttgct cgattaatat ttttgggggt gaacgaatgg 1646341 ctaaaatgag agtatacgaa tatgcaaaag cgttaaatgt ttcaagtaag gaaattttga 1646401 ccgcactgaa gaacatggat ttagaagtga ataatcacat ggccatgctt gaagaaaagg 1646461 ccattaaaaa gctagatgcc aaatataaaa aaggcggcgc agctgctaaa tctcaaaagc 1646521 cagcagaaac gaacaaaaac aaacagccac aaggggttaa tcagcaatca gctggaaatc 1646581 aaccaaataa aattcgagac ggaaagaaga atgacgtgca gaataatcaa tttaacaaaa 1646641 acaagaagaa taacaacaac aaaaaaaata aacgcaacaa caacaataat aaaaaccaac 1646701 atcagcaaaa gcctgtaaag ccgaaaaaag agcttcctga gaaaattaca ttctctggca 1646761 ctttaacagt tggcgcactt gctgaagagc ttggcaaaga gccttcagaa ctcattaaaa 1646821 agctgatgct tcttggcgta atggcaacca ttaaccaaga gcttgataaa gacacaatcg 1646881 aactcattgc atcagaatat ggtgttgaaa cagaagaggt cattgtgctt gaagaaacag 1646941 agctggaaaa atacgaagag cctgataatg aagaggatct tgaaattcgt cctcctgtcg 1647001 tgacaatcat gggccacgtt gaccatggga aaacaacgct tcttgacagc atccgtaaaa 1647061 caaaggttgt tgaaggggaa gcaggcggaa tcactcagca tatcggcgct tatcaaattg 1647121 aagagaacgg caagaaaatc acgttcttgg atacaccggg ccacgccgca tttacaacaa 1647181 tgcgcgcacg cggtgcagaa gtaactgata ttacgattct tgtcgtagct gccgatgacg 1647241 gtgtcatgcc gcaaacagtt gaagcgatta accatgcaaa agcagcagag gttccaatca 1647301 tcgttgctgt gaataaaata gataaagaat ccgcaaaccc tgaccgtgta atgcaagaac 1647361 tgacggaata cggacttgtc cctgaagctt ggggcggaga aaccattttt gtgccgcttt 1647421 ccgctttaac tggaaaaggc attgatgagc tcgttgaaat gattttgctt gtcagtgagg 1647481 tagaggaact gaaagcgaat ccgaatcgtc aggcaaaagg aacggttatt gaagctgaac 1647541 tcgataaagg cagagggtca gtcgcgacgt tgctcgtaca gactggaaca ctgcatgtcg 1647601 gtgatccgat cgtagtcggc aatacatttg gccgtgtccg tgcaatggtc aacgacattg 1647661 gccgccgtgt gaaaactgcc ggcccgtcaa ctccggttga aattaccggt ttgaatgatg 1647721 tccctcaagc gggagaccaa ttccttgtct ttaaggatga aaaaacagct cgttctgtcg 1647781 gtgaagcccg tgcttcgaaa cagcttgaag agcagcgcag cgataaagcg aagctcagtc 1647841 ttgatgattt atttgagcaa attaagcaag gtgatgtaaa agacatcaac ctcatcgtaa 1647901 aagctgacgt tcaaggatct gctgaagctt taacggctgc acttcaaaaa attgaagtag 1647961 aaggcgttaa agtgaaaatc atccatacag gcgttggtgc gattactgaa tcagacatta 1648021 tcttggcatc tgcttccaat gcaattgtta tcgggtttaa tgtgagaccg gacggaaatg 1648081 ctaagagtac ggctgaagct gaaaatgtag atattcgact tcaccgtatc atttacaaag 1648141 taatcgacga gattgaagct gccatgaaag gtatgcttga tcctgaatat gaagaaaaag 1648201 taattggtca agtagaagta cgccaaacat tcaaagtatc taaaatcggt acaattgccg 1648261 gcggatatgt tactgaagga accattacgc gcgacagcgg cctccgttta attcgtgacg 1648321 gcgtcgtcat ctttgaaggc gaagtagatg ttctgaaacg ctttaaagac gatgtgaaag 1648381 aagtttcaca aggctatgaa tgtggtatta caattaagaa atacaatgac attcgtgaag 1648441 gtgacatcct tgaagcgttt gtcatgcaag aaattgaaag aacgtgatcg gatttgcgga 1648501 gtgtgaatgc atcatttatg atgcaggatc gctaaaagaa aagcgtgccg ttctgaagcg 1648561 gattttaacc agggttcaaa acaagttcaa tgtttcgatt tcggagattg gctatcagga 1648621 cacctggcaa agaaccagct tcggaatcgc cgctgtttct tcctctcgcg ttcaaacaga 1648681 aaaagaactg cagcgcgtcc tagcgtttat cgattctttt cctgaaattg aacggacgat 1648741 cactaggaca gagtggtttt aacttagagg tgattgaatt gagtatgaga gcaaaccgtg 1648801 tcggcgagca aatgaaaaaa gaactcggtg atattatcag ccgcaagctg aaagacccga 1648861 gaattggttt tctgacagta acggatgtac gtgtatcagg tgatttgcaa attgcaaagg 1648921 tgtatatctc ggttctcggt gacgagaaaa aacgggaaga agcgctgaaa gggctggcaa 1648981 aagcgaaagg atttatccga tccgaaatcg gcagccgcat cagacttcga aaaacgcctg 1649041 aaattgaatt tgagttcgat gaatcaatcg attacgggaa tcggatcgaa acactgattc 1649101 acgaattaca ttcagagaaa ccatctgaat aaaaaaagag aggataggcg tatatcgtct 1649161 gtcctctttc ttcgtttata agaaaaaaac tcaaaagaag gagtgaaagg caaatggtta 1649221 acggagttct ccttttacat aaacctgttg gcatgacatc gcacgactgt gtcatgaaga 1649281 tccgaaagct gttaaaaaca aaaaaagtag gacatacagg aacgctcgat ccggaagtat 1649341 caggcgtgct tccgatttgt gtaggaagag cgacaaaaat agtcgaatac ttaactgaaa 1649401 aatctaaaac gtatgatgca gaaataacat tgggcttttc aaccacaaca gaggatcaaa 1649461 ccggagaaac ggtggaaaca aagcctgtca atcacgacat tgataaagcg gatgtagaaa 1649521 aggttttaaa cagtttaaag gggaaacaag aacaaattcc gcccatgtat tccgctgtaa 1649581 aagtaaacgg caaaaaatta tacgaatacg caagagcagg gattgaagta gaacgtccga 1649641 aacgtatgat aaccattgaa gacattgccc tgacaacaga gattaaacat catggagaaa 1649701 ccgcaagctt ccggtttaca gtgacttgct ccaaagggac ctatgtaagg acgctggcgg 1649761 tcatgatcgg agaaaagctc ggatatccgg cccatatgtc tcatttaatc cgtacggcat 1649821 ccggagattt ttctctcgac gaatgcttta cttttgatga actcgaagca caggcccaat 1649881 ccggaaccgt ggaagagcat acagttccta ttgaacgtgc gctcaatcat ttgccgaaat 1649941 ggatcataag tgatacatta gctaagaaag tagaaaatgg ggctttgctt gagacgcccg 1650001 agcagttttc tgaaatgaca agtggagacc gtattgccgt ctttactgaa tccggaacct 1650061 gcttggcgat ctatttccct catcctgcaa aaaaagggct gttaaagccg gcaaaagtat 1650121 tgatgcaaaa aagcgaacaa tagaaaaaag gtgaccgttc tgtgaagacg atacatatta 1650181 cacatcctca tcatttaata aaagaggagc aggcaaaatc agtgatggcg ttaggttatt 1650241 ttgacggcgt tcatctcggg catcaaaagg taatcggcac agcgaagcaa atagccgaag 1650301 aaaaaggtct gacattagct gtgatgacct ttcatcccca tccttctcac gtgttgggca 1650361 gagataagga accaaaggat ctgattacgc ctcttgaaga caaaataaac caaattgaac 1650421 aattaggcac agaagttctg tatgtcgtta aatttaatga agtgtttgct tctctttctc 1650481 ctaagcagtt tatagaccag tatattatcg gccttaatgt gcagcacgca gtggcaggct 1650541 ttgactttac gtacggcaaa tacggcaagg gaacaatgaa gaccatgccg gatgatttag 1650601 acggaaaagc tgggtgcaca atggtagaaa aattaacgga gcaggataaa aaaatcagtt 1650661 cttcgtatat ccgtaccgcg cttcaaaacg gagatgttga attggcgaat gtcttgcttg 1650721 gacaacctta ttttattaaa ggaattgtca ttcatggtga taaaagaggg cggaccatcg 1650781 ggtttccgac agcgaatgtc ggtttaaata acagctatat cgttccgccc acaggtgtat 1650841 atgccgtaaa agcggaagtg aacggcgaag tttacaatgg cgtttgcaat attggctata 1650901 agccaacgtt ttatgaaaag cgccctgaac agccttccat cgaggtcaat ctgtttgatt 1650961 tcaatcaaga ggtatatgga gccgctataa aaatcgaatg gtacaaacgg attcggagcg 1651021 agcggaaatt caatggcatc aaagaattaa ctgagcaaat tgagaaagat aagcaggaag 1651081 ccatccgtta tttcagcaat ttgcggaaat aacttgcaac gcacgcaaat tttattctaa 1651141 aatatttgca tataggcacg atttttagta tgatagtttt cgtagtctta aaaccattgc 1651201 ttggcaatcc gaagtcaccg acggttgcta ggtaactggg gctaaatatg atttggaggt 1651261 gaaacaggat ggcaattact caagagcgta aaaaccaact catcaatgag ttcaaaacac 1651321 acgaatctga tactggatct ccagaagttc agatcgctat cctaactgac tcaattaaca 1651381 acttgaacga gcatttacgt actcacaaga aagaccacca ctcacgtcgc ggtcttctta 1651441 aaatggtagg taagcgtcgt aatcttctta cgtatctgcg taataaagac gtaactcgtt 1651501 accgtgagtt aattaacaaa ctaggcttac gtcgataatc gtaaaaagcg ggaggattcc 1651561 cgctttttta tcgtattaaa gcgaaatttc ttataacaaa tcattgaaat ccttttacat 1651621 actactttga cattgatatg ttcaattcat ttcgttcata ataggagtaa ttgattattt 1651681 cacacaacga agagaggagt tcgtaattgt atgggacaag aaaaacatgt ctttaccata 1651741 gattgggccg gaagaacgct taccgttgaa accggccagc ttgccaaaca ggcaaatggt 1651801 gctgtgatga tccgctacgg tgatacagca gtacttagta cagcaaccgc ttcaaaagaa 1651861 cctaaaccgc ttgatttctt ccctcttact gtaaactatg aagaaagatt atatgcggta 1651921 gggaaaattc cgggcggatt tattaaaaga gaaggacgtc caagtgaaaa agcggttctt 1651981 gccagccgtt taattgaccg tccgatccgt cctttgtttg ccgatggatt ccgtaatgaa 1652041 gttcaagtca tcagcattgt catgagtgtt gaccaaaact gctcttcaga aatggctgcc 1652101 atgttcggtt catctcttgc actttctgta tcggatattc cgtttgaagg accgattgca 1652161 ggggttactg tcggacgcat tgatgatcaa tttatcatta acccgacagt cgatcagctt 1652221 gaaaaaagcg atatcaatct tgtcgttgcc ggcacgaaag atgcgattaa catggtagaa 1652281 gcgggagcgg acgaagttcc tgaggaaatc atgcttgagg ccattatgtt cggccatgaa 1652341 gagattaaac gcctgattgc attccaagaa gaaattgttg cagcagtcgg caaagagaaa 1652401 tctgaaatta agctctttga aattgatgaa gagcttaatg aaaaagtaaa agctttggca 1652461 gaagaggatc tgctgaaagc catccaagtt catgaaaagc atgcccgtga agatgccatt 1652521 aacgaagtga agaacgcagt tgtggcaaaa ttcgaggatg aagaacatga tgaagacaca 1652581 atcaagcaag tgaagcagat tttatccaag cttgtgaaaa atgaagttcg ccgcctgatt 1652641 actgaagaga aagtaagacc ggacggccgc ggtgtcgatc aaatccgtcc gctctcttca 1652701 gaggttggcc tcttgccaag aacgcacggt tcaggtctat ttacaagggg acaaactcag 1652761 gccctcagcg tatgtacgct aggtgctctg ggagatgtgc aaatccttga cggcttaggt 1652821 gtcgaagagt cgaaacggtt tatgcatcat tacaacttcc cgcaattcag cgttggggaa 1652881 acaggaccga tgcgcggacc gggacgtcgt gaaatcggac acggagcact gggtgagcgt 1652941 gcgcttgagc cagttattcc gtctgaaaaa gacttccctt atactgtccg tcttgtttca 1653001 gaagtgcttg aatcaaacgg ttctacatct caagcaagca tttgcgcaag cacacttgca 1653061 atgatggatg ccggtgtacc gattaaagcg ccagttgctg gtattgcgat gggtcttgtc 1653121 aaatcaggcg aacattacac tgtcttgact gacatccaag gcatggaaga cgcgctcgga 1653181 gatatggact ttaaagtagc gggaactgaa aaaggcgtaa cggccctgca aatggacatt 1653241 aaaattgaag gcctttccag agagattctt gaagaagcgc ttcagcaggc gaaaaagggc 1653301 agaatggaaa tcctcaacag catgcttgca acattaagcg aatcaagaaa agagctttct 1653361 cgatatgcgc ctaagatctt aacaatgacc attaatcctg ataaaatccg cgatgtcatc 1653421 ggaccaagcg ggaaacaaat caataagatc atcgaagaaa ccggtgttaa aattgatatt 1653481 gagcaggacg gcacaatctt tatttcctct acagatgaaa gcggcaacca aaaagcgaaa 1653541 aaaatcatcg aagaccttgt gagagaggtt gaagtcggcc aactttacct aggtaaagtg 1653601 aaacggattg aaaaattcgg ggctttcgtt gaaattttca gcggaaaaga cggtttggtg 1653661 cacatttcag agcttgcgct tgaacgcgta gggaaagttg aagatgttgt gaaaatcgga 1653721 gacgagattc ttgtcaaagt cactgaaatt gataaacaag gacgagtgaa tttatcccgc 1653781 aaagcggtgc tccgtgaaga gaaagaaaaa gaagaacaac aatcttaaat gaaaacataa 1653841 aaggagcctg ggagacccgg cttctttatt ttgaagcttt tcaaaagcag gcgggttcta 1653901 ccttgtcctt ctccttcata atgtgaggtg agggggggac agaacatgta caaaaaattt 1653961 gtaccgtttg ccgttttttt atttcttttt tttgtctcat ttgagatgat ggaaaatccg 1654021 catgcacttg attatatagg ggcaatgaaa aaagatacgg tgactgtcac ggcgtcaaaa 1654081 gacccgttat atgaagaatt gcttcaaaaa gcgccggagt acgaagttaa gccccagaat 1654141 gcaagaattg ataaagtgtg gaaaagcatt ccaggctaca atggattaaa ggtcaatatt 1654201 gaacaatcat ataaaaaaat gaaacagcat ggtaagtttc gggaaaaaga tttggtgtac 1654261 agtcaagtaa aaccaagtgt tcatcttgag tcacttcagc ctgagcctat ttataaagga 1654321 aatcctgaca aaccgatggt ggctttttta atcaatgtgg catggggaaa tgagtatttg 1654381 gaaaaaatgc ttcctattct gcaaaagcac caggttaaag ctacgttctt tttagaaggc 1654441 aattgggtga gaaacaatgt acagctcgct aagaagattg caaaagacgg acatgaaatc 1654501 ggaaatcatt catacaatca tccggatatg agcaaactga ctacaggaag aatttccgag 1654561 cagctcgaca agactaatga acaaatagaa caaacgatcg gcgttaagcc aaagtggttc 1654621 gctccgccaa gcggaagttt cagaaaagcg gttatcgaca ttgcagcaga gaaacagatg 1654681 ggaacagtca tgtggacagt tgatacaatc gattggcaaa agccggctcc gtctgtactt 1654741 cagacgagag tgttaagcaa gatacataat ggtgccatga ttttaatgca tccgactgac 1654801 cctacggcgg aaagtcttga agcgctgatt acacagataa aagacaaagg atatgcgctt 1654861 ggaacagtca ctgaactaat ggatgaaaca agactattga agtaacagat gaaggcagct 1654921 tgtctttgaa taggaggaac aaatttgatt aaacgatata cgtgtcaaaa tggtgtaaga 1654981 attgtgctgg aaaataaccc gacagtccgt tctgttgcga tcggcgtatg gatcggcaca 1655041 ggttcgagac atgaaacgcc ggagataaac ggaatttctc actttttaga gcacatgttc 1655101 tttaaaggga cgagcacaaa atctgcacgc gagatagcag aatcttttga tcgtattggc 1655161 ggccaggtca atgcgtttac ttcaaaggaa tatacctgct actatgcaaa ggtgcttgac 1655221 gagcatgcga attacgcgct ggacgtatta gcagatatgt tctttcattc aacgtttgat 1655281 gaaaacgagc tgaaaaaaga gaaaaatgta gtatatgaag aaattaaaat gtatgaagat 1655341 gcgccggacg acattgtaca tgatttattg agcaaagcca cttacggcaa tcattcttta 1655401 ggctacccaa ttttaggaac ggaagaaacg cttgcttcct ttaacggtga ctctctcaga 1655461 caatacatgc atgattatta tacgccggac cgagtggtga tttcggtagc gggcaatata 1655521 tctgacagtt ttatcaaaga tgtagaaaaa tggttcgggt catacgaggc gaaaggcaaa 1655581 gcgacaggcc ttgagaagcc tgagttccac acggaaaaac tgacgagaaa aaaagaaaca 1655641 gagcaggctc atttgtgcct tggatttaaa ggcttagagg ttggccatga acgtatttat 1655701 gatttaatcg tcctcaacaa tgtgctcgga ggcagcatga gcagccggct gttccaagat 1655761 gtgcgtgaag ataaaggact tgcttattct gtttacagct atcacagctc atatgaggac 1655821 agcggaatgc taacgattta cggcggaacg ggtgcaaatc agcttcagca gctgtcggaa 1655881 acaattcaag aaaccctggc cacattaaaa cgtgacggca ttacctcgaa agaactggaa 1655941 aacagcaaag agcaaatgaa gggaagctta atgctgagct tagaaagcac aaacagcaaa 1656001 atgagccgaa acggaaaaaa tgaactgctg ctcggcaaac ataaaacatt agatgaaatt 1656061 atcaatgaat taaacgccgt gaacttagag cgtgttaatg gccttgccag acaattgttt 1656121 accgaagact atgcattagc acttatcagc ccttccggca atatgccgtc ttaaaaagga 1656181 aagcctgccc cataatggag caggcatttt ttaatccctt tcatcataca tagtacaagg 1656241 gggtgacaga catgcggctc agtgaattat cgggaaagga aattgtagac atcaaaagag 1656301 ctgaacggct cggagtgctc ggccagaccg atttggaaat caatgaacag gatggacaga 1656361 ttacagcact cctcattccc acagttaagt ggtttggttt gagaaagcaa ggtcatgaca 1656421 ttcgtgtccc atggcaccat attcaaaaga tcggttcaga tatgattata ttagatgtac 1656481 ctgaggaaat gcctcctcga caagagtaaa tagcccaatt gactgtgaag cgggctctaa 1656541 agaaaacatc tgaaacatcg gctgccggag ccgatgtttt tttatatgga aaaagcgcat 1656601 cttttatatt caccggtatt tccttttgat cataagatga aggggagctt aacaactaga 1656661 gatccagtat atacaaagaa ggtgaacgtt tagaatgtta accggattga aaattgcagt 1656721 tatcggcggt gacgcaagac agctcgaaat tataagaaag ctcactgaac agcaggctga 1656781 catctatctt gtcggttttg accaattgga tcacggtttt accggggcag taaaatgcaa 1656841 tattgatgaa attccttttc agcaaataga cagcatcatt cttccagtat ccgcgacaac 1656901 aggagaaggt gtcgtatcga ctgtattttc gaatgaagaa gttgtgttaa aacaggacca 1656961 tcttgacaga acgcctgcac attgtgtcat tttctcagga atttctaacg cctatttaga 1657021 aaacattgca gctcaggcaa aaagaaaact tgttaagctg tttgagcggg atgacattgc 1657081 gatatacaac tctattccga cagtagaagg aacgatcatg ctggctattc agcacacgga 1657141 ttatacgata cacggatcac aggtggccgt tctcggtctg gggcgcaccg ggatgacgat 1657201 tgcccgtaca tttgccgcgc tcggggcgaa tgtaaaagtg ggggcaagaa gttcagcgca 1657261 tctggcacgt atcactgaaa tggggctcgt tccttttcat accgatgagc tgaaagagca 1657321 tgtaaaagat atagatattt gcattaatac cataccgagt atgattttaa atcaaacggt 1657381 actttctagc atgacaccaa aaaccttaat attggatctg gcctcacgtc ccgggggaac 1657441 ggattttaaa tatgccgaga aacaagggat taaagcactt cttgctcccg ggcttccagg 1657501 gattgtcgct cctaaaacag ctgggcaaat ccttgcaaac gtcttgagca agcttttggc 1657561 tgaaatacaa gctgaggagg ggaaataagg atgtcgtcat taaaaggaaa aagaatcggg 1657621 tttgggctga ccgggtcgca ttgcacatat gaagcggttt tcccgcaaat tgaggagttg 1657681 gtcaacgaag gagctgaagt ccgtccggtt gtcacattta atgtaaaatc tacaaatacc 1657741 cgatttggag agggcgcaga atgggttaaa aaaattgaag acctgactgg atatgaggcc 1657801 attgattcga ttgtaaaggc agaacctctt gggccgaagc tgccccttga ctgcatggtc 1657861 attgcgcctt taacaggcaa ttcaatgagc aagctggcaa atgccatgac ggacagcccg 1657921 gtgctgatgg cggcaaaagc gacaatccgg aacaatcggc ctgtcgttct gggtatctcg 1657981 acaaatgatg ctcttggttt aaacggaaca aatttaatga ggctcatgtc aacaaaaaat 1658041 atctttttta ttccattcgg gcaagatgat ccatttaaaa aaccgaattc aatggtagcc 1658101 aaaatggatc tgcttccgca aacgattgaa aaggcactca tgcaccagca gcttcagccg 1658161 attctagttg agaattatca gggaaatgac taaatttaca gaaaatcttt cccaaactaa 1658221 aaaattcggt catcacccgc atattctatg gtaaaataaa acgtaaaatc atagtcaaat 1658281 caattcaatg aagctgattg gcggaaggag ttttacagat gggaagaggt ttacacgtag 1658341 ctgttgtcgg agcgacaggg gctgtgggac aacaaatgct taaaacactt gaagacagaa 1658401 actttgaaat ggacacactt acattgctat cttcaaaacg ctctgcgggg acaaaagtca 1658461 cgtttaaagg ccaagagctg actgttcagg aagcttctcc tgagagcttt gaaggggtaa 1658521 atattgcttt gttcagcgcc ggcggaagcg tatcacaagc attggcacca gaagctgtaa 1658581 aacgcggcgc tattgttata gataatacga gtgcgttccg catggatgaa aatacaccgc 1658641 ttgttgtgcc agaagtgaat gaggcagact tgcatgaaca caacggcatt attgccaatc 1658701 caaactgctc tacaatccaa atggttgcgg cacttgaacc gatccgcaaa gcatatggct 1658761 taaacaaggt catcgtatca acttaccagg cagtatcagg agcgggtaat gaagctgtaa 1658821 aagagcttta cagccaaaca caggcgattt taaataaaga agaaatagag cctgagatca 1658881 tgcctgtaaa aggtgacaaa aaacactatc aaatcgcctt caacgcgatt ccgcaaatcg 1658941 ataaattcca agataacggc tatacgtttg aggaaatgaa aatgataaat gaaacgaaaa 1659001 aaatcatgca catgcctgac cttcaagtag cggctacatg tgtgagactg ccaatccaaa 1659061 ctgggcactc agagtccgtc tacatcgaaa tagaccgtga tgacgctaca gttgaagata 1659121 ttaaaaatct attgaaagaa gctccgggcg tgacacttca ggatgatcca agccagcagc 1659181 tttatccgat gcctgctgat gctgtcggca aaaacgatgt gtttgtaggc cgcatccgca 1659241 aagacttgga cagagcaaac ggttttcatt tatgggttgt ttctgataac ctattaaaag 1659301 gcgcggcatg gaactctgtt caaattgcag aaagcctgaa aaaactaaac ctcgtataaa 1659361 agagagaatt ttctaaagac gaatagaaga gagtaaggcg ctatcagcct gctctcttct 1659421 gttacgtccg aataatttgg agtgaaaaca gtgaagataa ttgttcaaaa gttcggcgga 1659481 acatcagtaa aagatgataa aggccgcaaa ctggctttag ggcatattaa agaagcaatc 1659541 agtgaaggat ataaggttgt cgttgtcgtt tcagcgatgg gccgaaaagg ggacccgtat 1659601 gcaacagatt ctttgctcgg gctgctttac ggcgatcagt cagcgatttc tcctagggag 1659661 caggatttgc ttttatcttg cggagagact atttcctctg tcgtctttac aagcatgctg 1659721 cttgataacg gtgtgaaagc agctgcgctg acaggggctc aggctggctt tttaacgaat 1659781 gatcagcata ctaatgcgaa aatcattgaa atgaaaccgg agcgtttatt cagtgtgctc 1659841 gccaatcatg atgcggtagt cgtcgcaggc ttccagggcg caactgaaaa gggtgataca 1659901 acaacaatcg gcagaggggg cagcgatacg tctgcagccg cactcggagc agctgttgat 1659961 gcggaataca tcgatatttt caccgatgta gaaggcgtga tgactgctga cccaagagtg 1660021 gtagaaaatg caaaaccgct tcctgttgtg acgtatacgg aaatctgcaa cctggcgtat 1660081 cagggggcca aggtcatttc tccgcgtgct gtggaaatcg caatgcaggc caaggttccg 1660141 atccgcgtcc gttcgactta ttcgaatgat aaaggcacat tggtgacatc acatcactct 1660201 tccaaggtcg gcagtgatgt ttttgaaagg ctgattacgg gaatcgccca tgtcaaagat 1660261 gtcacgcagt tcaaagtgcc tgcgaaaatc ggccagtata acgttcagac tgaagtgttc 1660321 aaggctatgg caaacgctgg aatcagtgtc gatttcttta acattacacc tagtgaaatc 1660381 gtctatacgg tagccggaaa taaaacagaa acagctcagc gtattttaat ggatatgggc 1660441 tatgatccaa tggtgacgag aaactgcgcg aaggtatcgg cggtcggcgc gggcattatg 1660501 ggtgttcccg gtgttacgtc caaaattgta tcggctcttt cagaaaaaga aattccgatc 1660561 cttcagtcgg ctgacagcca tacgacgata tgggtgctcg tccatgaagc ggatatggtt 1660621 cctgctgtaa acgctttgca tgaagtgttt gaactttcga agtaaatgtg attgaatcat 1660681 gatgaggtga ataaaatgaa tttcggaaat gtgtctacag cgatgattac accctttgac 1660741 aataaaggga acgtagactt tcaaaaactg tctacactga ttgattactt gttgaaaaac 1660801 ggaacggatt ctttagtagt agcgggaaca actggagaat ctccgaccct ttcaactgaa 1660861 gaaaaaattg cgctttttga atatacggta aaagaagtaa acggacgggt gcccgttatc 1660921 gctggtactg ggagcaacaa cacgaaagat tccattaagc tgacaaaaaa agctgaggaa 1660981 gcgggcgtgg acgctgttat gcttgttacc ccgtattaca ataaaccttc tcaagaagga 1661041 atgtaccagc attttaaagc aattgcggca gagacatctc ttccggttat gctctataat 1661101 gttcctggcc gtacggttgc ttctcttgct cctgaaacga cgatccgttt ggcggcagac 1661161 attccgaatg tggttgcgat taaagaagcg agcggagacc tcgaagcgat tacaaaaatt 1661221 attgctgaaa cacctgaaga cttctatgtc tattcagggg atgatgctct aacgcttcca 1661281 attctttcag ttggaggtag aggagttgtg tcagtggcga gccatattgc aggcactgat 1661341 atgcagcaaa tgatcaaaaa ttatacgaat gggcaaacag ctaatgcggc actgattcat 1661401 cagaaactgc tgccgattat gaaggaactg tttaaagcgc ctaatcctgc tccagtcaaa 1661461 acagcgcttc agctgagagg tcttgatgtc ggttctgtgc gtctgcctct agtcccatta 1661521 actgaggatg aacgtctgag cttaagcagc acgatcagcg aactgtaaga aaatttcata 1661581 cagtgaaaca aacgcggtca ttctcacatt cagctgagtt tgaccgtttc ttttacatat 1661641 tggttttccc taaaccttct gctttatctt gttttctaaa tttactttca gttataatag 1661701 gaacaagtga tgatggacgg gtatgagact aggaggatat agattttgaa aaagaaaaat 1661761 acagaaaacg ttagaattat cgcccttggc ggtgtcggag agattgggaa gaacctttat 1661821 gtcattgaaa ttgactcaga catatttgtc gttgatgccg gccttatgca tccagaaaac 1661881 gaaatgctcg gtattgatgt agtgattcct gacatatcat atttgattga acgggctgac 1661941 cgcgtcaagg caatcttttt aacgcacggg cacgatgaaa atatcggcgg cgttttttac 1662001 ttattaaaca agctgtccgt tccagtgtac ggaacaaaac tgacgcttgc actgttaaga 1662061 gagaaattaa aacaatacgg acataaccga aaaactgatt taagagaaat tcactccaaa 1662121 tctgtcatta catttgaatc aacaaaggta tcgttcttta gaacgattca cagcattcct 1662181 gattctgtag gtgtgagctt taaaacatca cttggatcta ttgtatgcac gggagacttc 1662241 aaatttgacc aaacacctgc acttaatcag acgtgcgaca ttggcgagat cgccaagatc 1662301 ggcaatagcg gcgtgctcgc tctgctttct gacagtgcaa atgcggaacg gccgggttac 1662361 accccttcgg aagcggctgt cagcggagaa atttcggatg cgctgtataa ttcacagaac 1662421 cgggtgatta ttgctgtttt cgcatccaat attaaccgga ttcagcaagt cattcatgca 1662481 gcggctcaaa atggcagaaa gattgccgta gccggaaaaa atcttcaatc tgtcctgcag 1662541 ctggcgagaa agttaggata tattgaagca gatgatgaat tgtttatttc tgtacaggat 1662601 gtcaaaaaat atccgaagcg cgaagtggcc attattacag ccggaagcca aggtgaacca 1662661 ttagctgctt tgacaagaat ggcaaacaaa gctcacaaac agctgaacat tgaagaaggg 1662721 gatacggtgg tcattgcgtc aactccgatt cccgggcagg aactcattta ctctaaaaca 1662781 gtagatcttc ttgcgagagc cggtgcacaa gtcatctttg cccaaaagcg tgttcatgta 1662841 tcaggccacg gctcacaaga agagttaaag ctgatgatca acctgcttaa accaaaatat 1662901 ttgattcctg taaacggcga atacagaatg caaaaagctc attcaaaaat cgctgaagaa 1662961 accggcatga agcgcagtga catcttctta attgaaaaag gcgacgtcgt tgaattccgc 1663021 ggccaaaacg taaaaattgg ggataaagtt ccttacggca atattttaat tgatggttta 1663081 ggtgtcggtg atatcggcaa tatcgtattg agagaccgcc gcttgctttc acaggacgga 1663141 attttaatcg ttgtcattac acttgataaa caaaagaaac atcttgtatc aggaccagaa 1663201 attatcactc gcggctttgt ttatgtaaga gagtctgaag gtcttatcgt acaggctact 1663261 gagcttgtac ggtccatcgt gacagaagcg actgaaacat caaatgtcga atggtcaacg 1663321 ctgaagcagg caatgcggga tgctttgaac caattccttt atgaaaaaac gaaacgtaaa 1663381 ccgatgatca tcccaattat tatggaagta taatgactga ctaaagaccg gagctgctcc 1663441 ggtctttatt ttttgtcctt caagccggga ttgaatgaag tatctttgtt cataatacaa 1663501 agagaaactc ggaaaggatg aaagcgagat ggatcatcgt atggaaaaca cagaagaaga 1663561 gcgtcctgaa aaaaatgatg cgaaggacag cattatgaat aaaatacagc agcttggtga 1663621 aacgacgctt ccgcagctgc cccaagatac aaatattcat tgtctgacca ttatcggaca 1663681 aattgaaggc catgttcagc ttcctccgca aaacaaaaca acaaaatatg aacatgtcat 1663741 cccgcagatt gtggcaattg aacaaaatcc caaaattgaa ggcttgctga tcatattaaa 1663801 tactgtcgga ggagatgttg aagctggtct tgccatagcg gaaatgcttg catctttatc 1663861 gaaaccgacc gtttctatcg tgcttggcgg ggggcattca atcggcgttc cgattgctgt 1663921 atcctgtgat tacagctata tcgccgaaac agcaacgatg acgattcatc cagttaggct 1663981 caccgggctg gtcatcgggg tgccgcaaac gtttgaatac ctggataaga tgcaagaaag 1664041 agttgttaaa tttgtgacaa gccattccaa tataaccgaa gagaagttta aagagctaat 1664101 gttttcaaaa ggaaacttaa cacgcgatat cggaacaaat gtagtcggta aggatgcagt 1664161 taaatacgga ttgatcgatc acgcaggcgg tgtcggacag gcaatcaata aactgaatga 1664221 gctcatcgat gaagcaagga aagaagaagg acggatgatt caatgattct ttataccgtg 1664281 atgcctcagg aaattgtgtt tgcagaacag aaccaagaga caagcgcaca tgagcaaatt 1664341 gaatataaag gtgtaccgct tctagtcgaa atgaaaggga atgaagcgga agtcattcaa 1664401 atcatgagca ccaatccaat gcattttctg catccggaca tttcaccggg acaaaagctg 1664461 aaattaaacg tataagaatc caaccctttt ttaagggcaa aatatgctat aataggggaa 1664521 tcctacagaa aaaacgcagc ctgtaaacgg ctgctttctt cattatgtat gaacttacat 1664581 tttttaacgc agtaaggtga tgagtgtggc aaagaaaaaa cgaaaatcaa gaaaaaaaca 1664641 ggcgaaacag ctcaatataa aatacgagct caacggattg ctgtgtatag ccatttcaat 1664701 tatcgcaatc ttgcagctgg gggtagtcgg gcaaacgttt atctatttgt tccgcttttt 1664761 tgctggagag tggtttattt tatgcttgtt aggtttattg gtgttaggag tctcactgtt 1664821 ttggaagaaa aaaaccccaa gccttttaac gagacgaaag gccgggttgt actgtattat 1664881 cgcaagcata ttgctgcttt ctcacgtgca gctatttaaa aatttgacgc acaaagggtc 1664941 tattgagtct gcaagcgtgg tgcgcaatac gtgggaattg tttttaatgg acatgaatgg 1665001 cagctctgct tcacctgatt taggcggagg gatgatcggt gcgctgctgt ttgcggcttc 1665061 acactttttg tttgcgtcga ctggttctca gatcatggca attgtcatga ttttgatcgg 1665121 aatgatttta gtaacaggac gctcgctgca agaaacgcta aaaaagtgga tgagcccgat 1665181 tggacgtttt ataaaagaac aatggttagc atttattgat gacatgaaat ccttcaaatc 1665241 aaatatgcag tcatcgaaaa aaacgaaagc gccgagcaaa aaacaaaaac cggcccgcaa 1665301 aaaacagcaa atggaaccgg agcctcctga tgaagagggg gattatgaaa cagtatcgcc 1665361 tcttattcat tcagagccga ttatctcaag cttttctgat cgtaatgaag aggaagagtc 1665421 tccagttata gaaaagcgcg ccgaacctgt gtcgaagccg cttcaggaca tccaaccgga 1665481 gacaggtgat caggaaactg tttctgctcc tcctatgacc tttacagagc tcgaaaataa 1665541 ggattacgag atgccgtcac tggatttgct ggcagatccg aagcataccg gccagcaggc 1665601 tgataaaaag aatatttatg aaaatgcgag aaagcttgaa cgcacattcc aaagctttgg 1665661 cgtaaaggcg aaagtcacac aggttcatct cggaccggcc gtaacaaaat atgaagtata 1665721 tcctgatgtc ggagtgaagg ttagcaaaat tgtcaattta agcgatgatt tagcgcttgc 1665781 gcttgctgcg aaggatatca ggatcgaagc gcctatacca ggcaaatcag caatcggaat 1665841 tgaagttcca aacgcagaag tggcaatggt ttcgctgaaa gaagtgctgg agtctaaatt 1665901 gaatgacaga ccggatgcga agctgttaat tggactcggc cgcaatattt caggtgaagc 1665961 tgtattggct gagttaaaca agatgcccca ccttttggtc gcaggcgcaa ccggtagcgg 1666021 gaaaagtgtc tgtgtcaacg gcattattac aagtatttta atgcgggcga aaccgcatga 1666081 agtgaaaatg atgatgatcg atcctaaaat ggtagagcta aatgtctaca acgggattcc 1666141 gcatttgctt gctcctgttg taaccgatcc gaaaaaagcg tcgcaggctt tgaaaaaggt 1666201 tgtcaatgaa atggagcggc ggtacgaatt attttctcat acgggtacaa gaaatattga 1666261 aggatacaat gattatataa aacgcgccaa caatgaagaa ggagcgaaac agccagagct 1666321 gccttatatt gttgtcattg tggacgagct agccgatctc atgatggtcg cttcatctga 1666381 tgtggaagat tcgattacga gattgtccca aatggcgcgg gctgccggca tccatcttat 1666441 tattgcgaca cagcggccat cggtggatgt tatcacaggg gtgatcaaag cgaacattcc 1666501 gtcacgaatc gcgttcagcg tatcttcaca gacggattca aggaccattc ttgacatggg 1666561 tggcgctgag aagcttcttg gccgcggcga tatgctgttt ttacctgtag gggctaacaa 1666621 acctgtccgt gtgcagggag catttttgtc ggatgacgaa gtggagaagg tcgtcgacca 1666681 tgtgattact cagcagaaag cgcaatatca agaagaaatg attcctgagg agacgacgga 1666741 aactcattcc gaggttactg atgaacttta tgatgaagct gttgaattaa tcgtcggcat 1666801 gcagacggca tctgtttcaa tgctgcaaag aagattcaga attggctata cgagagcggc 1666861 gcgcctgatt gacgcaatgg aggaacgcgg tgttgtcgga ccgtatgaag gcagcaaacc 1666921 tagggaagta ttattatcaa aagagaaata tgatgagctc tcttcttaat gaagggagtt 1666981 ccgctttcta tagttgtcaa taatgatatt atgtaaactg atcacctttc tatttatttt 1667041 ttcgacaaaa catgatatag ttgtcccaat tgttcaataa tttttatcga aagtggttta 1667101 cggaggggaa acatgtctac aaaagctgat aatcggcact tgtatttgaa agtaattgaa 1667161 cgaattaaag aggatataaa aaatgggatc tacactgaga aggaaaagct gccttctgaa 1667221 tttgagcttt ccaaaaagct tggtgtcagc agagcgacgc taagagaagc cttgcggata 1667281 ctggaagaag agcatgtgat tatcagaagg catggtgtag gcacttttgt ccattctaag 1667341 ccgttatttc tttcgggtat tgaacagctg aacagtgtaa ccaagatgat agaacaggcg 1667401 aatatgaccc ctggcacgat ttttctatca tcacaagtgc ttatgccgtc tgaagatgat 1667461 acgaagagat ttcacttggc agaagggcaa gaactttttt accttgaacg agtcaggaca 1667521 gctgacggac agccgattgt gtattgtata gacaaaattc cgatgaatat tttgccgaat 1667581 tctttttctc atcagcaaga atctatgttt gacctgctag agaaaaattc aggctccgta 1667641 atcagctatg cagtaactga tatagaaccg atcggctatc acgataccat ttctccagtg 1667701 cttgaatgcg atccggaaac agctcttttg ctgttaaaac aaacccatta cgatcagcac 1667761 gataaaccgg tgctttattc tttaaattat tttagagcgg ataaattcag atttcatgtt 1667821 ttgcgtaaac gattctaaaa acggacgcct gtatgtgtct gtttttttat ttgcactgat 1667881 tcatgtttct ttgtacatac tttcattccg gttaacgcaa tatataaggg atgacaagaa 1667941 agtgaatggg tgaaaatgtt gagagagaaa aatggaatga aaaatattat tgcattgtct 1668001 tctgtcccgc ttgtgatgac actcgggaac tccatgctga ttcctgttct tccgatgatg 1668061 gagaaaaagc tgtctgtgac ttcatttcaa gtatctttaa tcattactgt atattcagta 1668121 gtagcaatta tttgcattcc gattgccgga tatttgtcgg atcgtttcgg gagaaaaaaa 1668181 atattgcttc catgcctcct cattgcagga ttggggggag ccgtagctgc ttttgcctcg 1668241 acctatatga aaaatcctta tgctatgatc ttggcggggc gggttcttca aggcattggt 1668301 tctgcaggtg ccgctccgat tgtcatgccg tttatcggcg acctgtttaa aggagacgat 1668361 gaaaaggtca gcgcgggtct tggcgatatt gaaaccgcca acacgtcagg gaaggtactg 1668421 agtcccatac ttggagcctt actggcttct tggtattggt ttgtaccgtt ttggtttatt 1668481 ccgtttttct gtttgatcag ctttttgctc gtattgtttt tggtggccaa gcctgaagaa 1668541 gatgaagatg cgcctgctgt ttctgagttt attaagagtg tgaagaaaat ttttaaacag 1668601 gatggtcgct ggctttatac ggtcttcatt atcgggtgtg tcattatgtt tttgttattt 1668661 ggcgtattat tttatttatc agatacgctg gagaacaagt atgctattga cggagtagct 1668721 aaaggcggat tactggcaat cccacttttg tttttgtcaa ccagttcttt tatagctggc 1668781 aaaaagatcg gtaaagataa aggccgaatg aaattttgcg ttgttacagg aatgattctg 1668841 ttaacccttt cgtttattgc cttgtggtgg aaccacagtt tttatttttt atttgtcttt 1668901 ttaagctttg gcgggattgg gattggaatg gctcttcctg ctttagatgc attgataacc 1668961 gaagggattg aaagtgaaca atgcggaacc atttcctcct tttacaatag catgcgcttt 1669021 ataggagtag ctctcggtcc acctgttttt gctgcattaa tgtctaatgc aaactggatt 1669081 attttcatac tctcggcgtt ttgcagcatc gtttctttat ttttagtgct ctttactgta 1669141 gatgctaaaa aaagtgaaga agaaaaaaac ttagggacgg tctagccagc cgtctttttt 1669201 tgcgctttct tgcacagttt acaactgtac ctatacagca tgcggaggtt attgtttcct 1669261 tataaatcct acagttgcta taattacatg aaagagtgtt tctgcggatg ctgaaaattg 1669321 gtcataatac atactaatta agaaatgaac gaaggaggtt ccatatgtca tatgttaatg 1669381 aactcaaatc aaagcacggc ggtttaaccg cacacattgt aaaaacagaa aaattcaaaa 1669441 ccgtctcgct tatttttaag atgcttgcgc cgctgacaaa ggatcaagtc accaaaagag 1669501 cgcttctccc gcatgtgctt cttcgcggaa cgaaaagcca tccgaaaacc gcaggattgc 1669561 gttcatactt ggatgagctg tacggcacgt cagtatcggc tgatcttacg aaaaaaggag 1669621 agcggcatgt cattacgttc aggcttgaaa tcccgaatga aaaatattta aaagaccaaa 1669681 cgccgcttct cgagaaaggg ctccagcttc tcgcagaact cgtcttttca cctgctttgg 1669741 agggagacgc ttttcagtca caatatgtgg ctcaagaaaa acggacgctt aagcaaagaa 1669801 tccaagccgt ctatgatgat aaaatgcgtt attcgaattt aaggctgata caggaaatgt 1669861 gcaaaaatga tccttacgcg cttcatgtca atggtgaaat cgacgatgtc gatgacatta 1669921 cggcagagca attatacgaa acataccaaa gcgctatcca aaaagaccag cttgatctat 1669981 atgttgttgg cgacgtggac agtaaccagg tacaatcggc aattgataag tatttcaaaa 1670041 cagaagagcg cactcttggc atgattgaaa acaatcacgc tgatgaaaaa gttcagccaa 1670101 aagaagtaat tgatgaagag gatgtcaagc aaggaaaact gaatatcggc taccgcacca 1670161 gcatcactta tacagatcag gattatcctg ctttacaagt gtttaacgga ttgttcggcg 1670221 gattctctca ttctaaactt ttcattaatg ttcgggaaaa agccagtctt gcttactacg 1670281 cggcttcgcg tatagaaagt tttaaaggct tgttaatggt gatgtcaggc attgaagtga 1670341 aaaattttga acaggcggtt tcgattattg ctgagcaatt ccaggcaatg aaaaatggcg 1670401 atttcagtga gcaggatata gcacagacaa aggccgttat tcgaaatcaa gtgctggaaa 1670461 cgattgatac agcatacggt ttatctgagt ttttatatca gcaggccgct gctcaagtcg 1670521 agattcctat cgaagacttt cttgccaata ttgagaatgt cacaaaagag gatatcatta 1670581 aagccggcga aaagattcag cttgatacga cttatttctt aaaagggacg gagggtgcat 1670641 cttgatcaaa ccaatcgaat atgaacagct tcaggagacg ctgtatcatg aaaaaatgtc 1670701 caacggcctt gatgtttacg ttttgccgaa aaaaggcttc aacaagacat atgcggtctt 1670761 tacaacaaag tacggctcga tagataaccg gtttgtccct ttaggtaaaa acgagatggt 1670821 tcacgtgccg gacgggattg ctcactttct tgagcacaag ctgtttgaga aagcggacgg 1670881 agacgttttt caagatttca gcaaacaggg ggcttctgcc aatgcgttta cgtcatttac 1670941 aagaacggct taccttttct caagcacatc aaatgttgaa cgcaatttag agacgcttat 1671001 cgatttcgta caggacccat attttactga aaaaacggtt gaaaaggaaa aagggattat 1671061 cgggcaggag attaatatgt acgacgataa ccctgattgg aggctttact tcggggtcat 1671121 tgaaaacatg tacaaagagc atcctgtcag aattgacata gcgggaacag tggaaagcat 1671181 ttcacatatt acaaaagacc ttctttatga atgctatgaa acgttttatc acccgagtaa 1671241 catgctcctt ttcattgtcg gccctgtaga tcctgaagcg attatttctc aggtaagaga 1671301 aaaccagggg aaaaagccgt atactgatca gccggagatc aaacgagaag aagtgaaaga 1671361 gcaagaagcg gttttccgaa aagaaaaaga gatcaaaatg aacgtgcagg gaccgaaatg 1671421 ccttgttggg ctgaaatcca aaaatccgtt taaattaggc aaagagctct taaagcatga 1671481 actttcaatg aacttattgc ttgaagctct ttttggcaaa agctctgccc agtatgaatc 1671541 actttatgaa aaaggatata ttgacgaaac gttcagcttt gattttactg ctgaatatgg 1671601 gttcggtttt gcggcgatcg gcggagatac gcctgagcct gatcaattgg ctgaagacat 1671661 ttcaagcatg cttttgcgcg ccggtgaact gattactgct gaaaagattg aacttgccag 1671721 aaagaaaaag atcggcacat tcttaaaagc gctgaattcc cctgaataca tcgccaatca 1671781 atttacccgt tatgcgttct tggatatgag cctgtttgat gttgtaacgg tactcgagca 1671841 gattaccctc gaggatgtcc agaacgtaat acaagaggaa atcgctgcag acagactgac 1671901 tgtctgcaag gttgttccta aatcataaac aaaacatccc tccagtgtga ggggtgtttt 1671961 tctgcggaaa gaaggaaaga ggatgaacaa aacagcacta atcaccggag caagcggcgg 1672021 cattggcaaa agcatcagcg aaacccttgc agctagagga tacaatctgc tgctgcatta 1672081 caatacaaat caaaacgcgg cagcggagct tgctgaaaaa ctaagtcaga tgtttggcgt 1672141 aaatgcggag atattacaag ctgacctgtc cgcgcaagat ggagcagata agctgacaag 1672201 ttcaattgtt cagccgattg atgcgattgt tttaaacagc ggacgaagcc attttgggct 1672261 gattacggat gtagataacg caacggtcca ggaaatggtt cagcttcatg tggcgagtcc 1672321 gtatatgctg acgagaaacc ttctgccagg catgattcgg aataaatcgg gagcgattgt 1672381 ggctgtcagc tcgatttggg gagagactgg agcatcctgt gaagtgttgt acagcatggc 1672441 aaaaggagct cagcattcat ttgtaaaagg attggctaag gagctggcgc caagcggaat 1672501 cagagtaaac gccgtagcgc cgggtgcagt tgatacaaat atgatgaatc aatttacccc 1672561 ggctgaaaaa gaagagatcg ctgatgagat tccgatcggc cggctggccc ggccgcaaga 1672621 aattgcggat gcaacagctt ttctcctgtc tgaaaaagcg tcatatatca ccggccaaat 1672681 tctgtcggtg aatggcggct ggcactgctg atccgaaaat attcggtgta tagtttcttt 1672741 tgcgaaggac acaataatct tgtaacttca catgaaatgg aggaaacaag catgtcagta 1672801 ttagaaaact gggatagctg gaaaaacttc cttggcgacc gtctgaacta tgcgcaagat 1672861 aaaggtatga gccaggatac gattacagat cttgcgacag aaatcggcag ctacttggct 1672921 aatgaagtgg aatctaagaa cgagcaggaa aaagtgctgg cagatctttg gagtgtagca 1672981 tcaaaagatg aacagcacgc cattgccaat atgatggtta agcttgttga aaataacagc 1673041 actcactagg aagagagggg atttttcctc tcttttttat gttttcctca tcacagcaac 1673101 attcttcttt ctaattagag aaaaatgctt tatgataaag gaaggtaaaa ttttgccaca 1673161 atgaaggggg tatatcattt ggcaaagctc gaatggtatt ttgaatatga aattcaagtg 1673221 aaccgccccg gactgctcgg ggatatttca tctcttcttg ggatgctttc tatcaacatc 1673281 gtaacgataa acggcgtcga tctttccaga aggggaatgc tcctcaggtg ccgccatata 1673341 gatcaaatta aacgattaga atcaatctta aaaacgatgg aaacaattaa agtaacgaag 1673401 cttagagaac cgaggcttcg cgaccgtctt gccgtacgcc acggccgtta tattcaacgg 1673461 gatgccgatg acaagaaaac gttccgcttt gaacgggacg agcttggctt attagtcgat 1673521 tttatggccg aattgttcaa aaaagaaggc cataaattaa tcggaatcag aggtatgccg 1673581 cgtgtcggga aaacggaatc gattgtagcc tctagtgtgt gcgagcaaaa ggtggctgtt 1673641 tgtgtcatca accttgctga agcagacgat aagaagccag ctgattgccg atgaatacag 1673701 cactgaaaat gtctttatcg ttgacggaat tgtgtcaaca cgaagagggt cagaacgcca 1673761 tctccagctg gtccgagaaa tcatgcggct gcctgcaaca aaagtggtgg agcatccgga 1673821 catattcgtt caaaatacag agtatacact agatgacttt gattatatta ttgaactgag 1673881 aaatgaccct gatgaggtta ttacatatga acatgccgag gaaccccaaa tgtttgatca 1673941 atccgggttt tcaagctttg atttttaaaa ttggaaggtg tttgttgtga ctgaactagg 1674001 aatccggctc aaagaagcca gagaggaaaa agcaatgtca ttggatgatc tccaagcggc 1674061 aacaaagatt caaaaaaggt atttaaccgc cttggaggaa ggaaactatg acattattcc 1674121 ggggaagttt tatgttcggg cattcatcaa gcaatatgca gaagccgttg ggcttgatgc 1674181 ggatcagctg tttgaggagc ataaaaaaga tatccctaat acgtatcatg atgatgtgtc 1674241 tgaaaagatc tccggcatga atcttcaaaa ggaaatgcca aagccagcat ctaaggcgct 1674301 ggagctgctg ccaacaatac ttgttattct cggcgtgatt gtcgtgattg ccattgtgta 1674361 cgcgatcatt caatttgcca atcacaaaaa cagtgatgat cacaatgcgg catcagaaaa 1674421 agcaattacg caaagtgaga gcaagtacga aatccctaaa gattcaacgc tgaaagagaa 1674481 tcaaaataac agctctgaaa aagagacaga cactaaaaaa gaaacgaaag aaaacgaaga 1674541 taagaaaaaa gaaaatgaca gtgagaagct ggagattaaa gctgctggca ctgaaggatc 1674601 gttaacgact tatgaagtgt ccggcgctga taaaatcgag ctggaactga aggcatcaga 1674661 cagctcctgg attagagtgc gcgatgaaaa cagcagctct ttaaaagaag gaacgctgaa 1674721 aaaagacgaa acctataaaa aagacataac tgatcagaaa caagttgata tccgcaccgg 1674781 atatgcacct aatctgaaaa taaaaatcaa cggtaaggtt ctttcatatg aacttgatcc 1674841 gaaaaaagtg atggcacaaa ccataaagat tgtaaataaa aaggaagaaa agtcatctta 1674901 attaccagat gacttttctt cacgtccgag tatgaaattg gaggggcttt atgtttaact 1674961 taccaaataa aatcacacta gctagaatcg cattaatccc aatcttcatg attatcatgc 1675021 tggcgccgtt tgactggggc aggctcgaag ttggagacga atccatcccg gtcgcacatt 1675081 tggcgggggc cattctattt attattgcat ctacaacaga ctgggtggac gggtattatg 1675141 cccgaaaatt aaatctcgta acaaacttcg ggaaatttct tgatccgctt gcggacaaac 1675201 tgctcgtatc cgcagcgtta attatccttg ttcaatttga tctcgctcca gcttggatgg 1675261 tcattgtgat tatcagcagg gagtttgccg tgacaggttt aaggcttgtc ttagccggaa 1675321 caggagaagt cgtagctgct aacatgcttg gtaaaatcaa aacctgggca cagattattg 1675381 cggtatctgc attgcttctt cataatcttc catttgaact tgtgtcattc ccgtttgcag 1675441 acttggcgct gtgggtagcc gtcttcttta ctgtcgtctc aggctgggaa tatttctcta 1675501 aaaattggga agcgttaaaa acatctaact aagaaagaag gacttcgtca tggaatttcc 1675561 aaaaaaagca gaaataattg cagtcggttc agagttgctg cttggtcaaa tcgccaatac 1675621 aaatgctcaa tttatcagca aacagctcgc tgaaatcggg gtcaacgtat tttatcatac 1675681 agcggtcgga gataacccgg agcggctgaa gcaggtcatc cgcattgctg aagaacgctc 1675741 tgacttcatt attttttcag gagggcttgg acccacaaaa gatgatctga cgaaagaaac 1675801 gattgcaaat acgctgggac gtccgcttgt gttaaatgat gaggcattcc aatccattga 1675861 ggactatttc aaacgaacaa aacgcacgat gtcacctaat aaccgaaaac aggcgcttgt 1675921 gatcgaaggc tctgacgtgc tggcgaatca ctttggaatg gccccgggaa tgctcacaga 1675981 gcatgaatcg cgctattata tgcttcttcc tggaccgccg agcgaattgc gtccaatgtt 1676041 tgaaaacgag gcaaagcctc ttctgctgaa aaagatgggt tcaaatgaaa aaattgtgtc 1676101 aactgttctt cgctttttcg gtatcggtga atctcagctt gaagccgatt tggaagatat 1676161 tattgatgca caaaccaatc cgacaattgc gcctttggcg gctgatggag aggtgacgct 1676221 gcgtctgaca gccaaacacg ccgatgaaaa ggaaacagag cgtctgttaa aagaaacaga 1676281 ggccgttatc ttagagcgtg tcggtgaatt tttctatggt tacgatgata cttctcttgt 1676341 aaaagagcta tctatagcat gtaaggaaaa aggcataaca atttctgcgg cagaaagctt 1676401 taccggaggg ctgttttctg aatggctgac ggatcatagc ggtgcctcaa aattatttgc 1676461 cgggggcgtt gtttgctata caaacgacgt gaagcagaat gtgcttggtg tcaagaagga 1676521 aacattagat cgttttgggg cggtcagcaa ggagtgcgca tccgaactgg ctaagggtgt 1676581 tcaaaaactc actggcagcg atatcggcat tagctttact ggtgtagcag gacctgatgc 1676641 tcaagaaggg catgagcctg ggcatgtgtt tatcggcatt tccgcaaatg gtaaagaaga 1676701 ggttcacgag tttcactttg cgggctccag aacggggatc agaaaacgcg gcgctaaata 1676761 cggctgccat ttaatcttaa agcttttaga gcaaaaataa tattttcagc acattatcct 1676821 cctaagaaaa catgatttct ctgatacatt atgatatttt gataggaatc acgccaagaa 1676881 aaaatccgaa tatgcgttcg cttttttctt ggcaaatccc ttcaaacagg gtatagtata 1676941 tgtagtggta acataaagga ggaaaaaata gaatgagtga tcgtcaggca gccttagata 1677001 tggctcttaa acaaatagaa aaacagttcg gcaaaggttc cattatgaaa ctgggagaaa 1677061 agacagatac aagaatttct actgtaccaa gcggctccct cgctcttgat acagcactgg 1677121 gaattggcgg atatcctcgc ggacggatta ttgaagtata cggtcctgaa agctcaggta 1677181 aaacaactgt ggcgcttcat gcgattgctg aagttcagca gcagggcgga caagccgcgt 1677241 ttatcgatgc ggagcatgcg ttagatccgg tatacgcgca aaagctcggt gttaacatcg 1677301 aagagctttt actgtctcag cctgacacag gcgagcaggc gcttgaaatt gcggaagcat 1677361 tggttcgaag cggggcagtt gacattgtcg ttgtcgactc tgtagccgct ctcgttccga 1677421 aagcggaaat tgaaggcgac atgggagatt cgcatgtcgg tttacaagca cgcttaatgt 1677481 ctcaagcgct tcgtaagctt tcaggggcca ttaacaaatc gaagacaatc gcgattttca 1677541 ttaaccaaat tcgtgaaaaa gtcggtgtta tgttcgggaa cccggaaaca acacctggcg 1677601 gccgtgcgtt gaaattctat tcttccgtgc gtcttgaagt gcgccgtgct gaacagctga 1677661 aacaaggcaa cgacgtaatg gggaacaaaa cgaaaatcaa agtcgtgaaa aacaaggtgg 1677721 ctccgccgtt ccgtacagcc gaggttgaca ttatgtacgg agaaggcatt tcaaaagaag 1677781 gcgaaatcat tgatctagga actgaacttg atatcgtgca aaaaagcggt tcatggtact 1677841 cttatgaaga agagcgtctt ggccaaggcc gtgaaaatgc aaaacaattc ctgaaagaaa 1677901 ataaagatat catgctgatg atccaggagc aaattcgcga acattacggc ttggataata 1677961 acggagtagt gcagcagcaa gctgaagaga cacaagaaga actcgaattt gaagaataaa 1678021 aataaaataa gtttcaaatg atacaaaagg ctgagtgaaa aactcagctt ttttgtattt 1678081 tgcaaaaaaa tgataaaaat attgcttttt ttgacaactt ttttagggct ttattcgtct 1678141 aacaaaacgt gtgcaaaatg gaatttattt tgggaggaaa aaatgaatga caagcccaac 1678201 ccgcagaaga actgcgaaac gcagacggag aaaactaaat aaaagaggaa aactgttgtt 1678261 tggtctttta gcagtgatgg tttgcattac gatttggaat gctcttcatc gaaatagtga 1678321 agaaaacgaa ccatctcaag aaactgcagc ggtttcaaat accgatcaga aaaaagaggt 1678381 caaaaagaaa actgccaaaa aatcagagga acaaatcaaa acagtggatc gaaaccaaaa 1678441 aatcagcaat tatttaaaag agatcggttt cagcggaaca gccatgattg tcagaaatgg 1678501 agaaatcgta acaaataaag gttttggcta tgctgaccgt aaacactaca ttcaaaataa 1678561 tccattgaca tctttttatg tcggttcatc acaaaaagcg ctgattgcaa ctgctatttt 1678621 gcagcttgag gaaaagggga aacttcagac aagtgatccg gtaagcacgt atttacctca 1678681 ttttcccaac ggacaaacga ttactttgaa gaatctgctt acacatacat cggggataaa 1678741 cggacatatt gaaggaaacg gcgccattac tccggacgat ttaataaaag atatagaact 1678801 tcagggaatc aaacgtcagc cgggcgtatg ggactacaag gattccaact attctgttct 1678861 tgcttatatt attgctgaag taagcggtga gccctatgaa cagtacataa agaatcatat 1678921 ttttaaacct gcgggaatga cgcatgcagg cttttacaaa acatatgaaa aagaacctta 1678981 tcctgccgtc gggtataaga tggagggcag caaaacagtt acaccgtata tacctgattt 1679041 atcccagctg tatggagcgg gtgatattta tatgagcgct atagatatgt acaaatttga 1679101 ccaagcgctg atagacggaa aactgtattc gcaaaaaagc tatgaaaaga tgtttacgcc 1679161 agggagcagc tccacatacg gcatgggatt ttatgttgct cccggaagct attcaaacca 1679221 tggtgttatg ccgggcttca atatcttgaa cagctttagc aaatctgggc aaaccattgt 1679281 tattttgttc tcaaacattc aaaataatgc taaattgggc caagtgaaca ataaaatata 1679341 ccagcttcta aatcaagaat gattggcgat cttcttttgg atgaattgca ttcggcacgt 1679401 gaaaagaaga ctggcctgca aacgttaaga tggcaagctt gacaagtatt tccgacacat 1679461 ttacaatgaa gttgtaacat ttgttttttt aacatgattg ttaaaccatt taaacttgac 1679521 aagggcgatg aacacactca ttccctgtga aggttctgta tgttgagaaa actagacaat 1679581 gtacatgccg acacttttta agcaacaacc aagttcatag caagaggagg tgaaagtatg 1679641 accccaatta tgatggttct catctccatt ttgctgattc tactcggttt agttgttggc 1679701 tactttgttc gtaaaaccat tgccgaagcg aaaattgcgg gcgcacgcgg tgcagccgag 1679761 caaattcttg aagatgcgaa gcgtgatgct gaagcactga aaaaagaagc tctgcttgaa 1679821 gcaaaggatg aaatccacaa acttcgaata gatgctgaac aggaagttcg tgaaagacga 1679881 aatgagcttc aaaaacaaga aaaccgttta ctccaaaagg aggaaaacct tgatcgcaaa 1679941 catgagggaa ttgataaacg ggaagcgatg ttggagaaga aagatcattc tctgaatgaa 1680001 cgacaacaac atattgaaga gatggaaagc aaagtggatg agatgattcg tatgcagcag 1680061 tctgagttgg aacgaatttc gagtctgact cgtgacgaag cgaaacaaat cattcttgag 1680121 cgggttgaaa acgagctttc acatgacatc gccatcatga caaaagaaac tgaaaaccgt 1680181 gcgaaagaag aggcggataa gaaagcgaaa aacattcttt cactcgcctt acagcgctgc 1680241 gcagcggacc acgttgccga aacaacggta tcagttgtca atcttccaaa tgatgagatg 1680301 aaaggacgta tcatcggacg ggaagggcgt aacattcgta cgcttgaaac gctgacagga 1680361 attgacctga ttattgatga tacgcctgaa gctgtcattc tttccggatt tgatccgatc 1680421 agacgtgaga cagccagaat tgctcttgat aaactcgttc aggatggccg tattcatccg 1680481 gcacggattg aagaaatggt tgaaaaatct cgccgcgagg tcgatgacta tattcgtgag 1680541 atgggtgagc aaacgacatt tgaggttggc gttcatggcc tccacccaga tctcatcaag 1680601 atcctcggcc gcttaaagtt ccgtacaagc tacggtcaaa atgtgcttaa gcattccatg 1680661 gaagtcgcat tcttggccgg tctaatggca tcggagcttg gtgaagacgc aaagcttgct 1680721 aaacgtgcgg gtcttcttca cgacatcggg aaagcaattg accatgaagt agaaggaagc 1680781 cacgttgaga tcggggtaga gcttgcgacc aaatataaag agcacccagt cgtgattaac 1680841 agtattgcat cacaccacgg ggacgaggag ccgacttcca ttattgctgt actggtagct 1680901 gcagcagatg cgctttccgc tgcaagacct ggcgcaagaa gtgagacgct cgagaattat 1680961 attcgaagac ttgaaaaact tgaagaaatt tctgagtcct acgaaggtgt tgaaaaatca 1681021 tttgccattc aggctggacg cgaagtgcga attatggtga agccggattc aattaatgat 1681081 cttgaggctc atcgactggc gcgagatatc cgcaagcgaa ttgaggacga gctcgattat 1681141 ccaggtcata ttaaggtgac agtaatcaga gagactcgag ccgtagagta tgcaaaataa 1681201 agtgatgcgc taagcatcac tttatttttt tgacggcaag gaattttcaa gaagaaagga 1681261 tttacaaaat gagaatttta tttatcggag atgttgtcgg ttcaccgggc cgtgacatgg 1681321 tcaaagaata tgtaccaaag ctaaaaacaa aatataagcc tcactttacc attattaatg 1681381 gtgaaaacgc cgcacatgga aaaggcctga cggaaaaaat ttatcacagc ttaatccagt 1681441 ccggcgcaga tgcaatcaca atggggaacc acacatggga caaaaaagaa atatttgatt 1681501 ttatagatga cgttccgaac ttggttcgcc cggcaaactt tcctgaagga acaccgggga 1681561 aagggatcac atatgtgaaa gcaaacggca aagaactagc agtcattaat ttgcagggac 1681621 gtacgttttt gccgccgctt gatgacccgt ttttaaaagc ggatgaattg atcgcagaag 1681681 ctgcgaaaag aacaccgtac atttttattg actttcatgc cgaagcgaca agtgaaaagc 1681741 tcgcacttgg ctggtacacg gatggacggg catcggctgt agtaggaact catacacacg 1681801 tgcaaacagc ggataaccgc attttgccga agggaacggc atatattact gatgtgggaa 1681861 tgactggccc gtatgacggt atactgggga tggacagaga gacgattatt aagcgattca 1681921 aaacgaacct tccagtccgg tttactgtcg ctgaaggaaa aacaacgctc agcggagttg 1681981 tcattgacat tgacgatcaa acgaaaaaag ccgtgaaaat tgagcgtatt ttaatcaacg 1682041 atgatcacat gttctttgaa tagttgaaca tatggttatt ttataaaaat attaaaaaga 1682101 aaagcaggaa tatagcaact ccttagtgaa tatagtaaaa atggaaggta gcccgctatt 1682161 tttgaaaagc attgtgggga tggctttttg gatagcaaca tctaataatg attgttctaa 1682221 tgaacactca cttatccatt gtaaaactaa gggggagcag aaatggaaat cttaaaagtt 1682281 tcagcaaaat cgagtccaaa ttcagtggca ggtgcgcttg caggcgtgtt gagagagcga 1682341 ggagccgccg agattcaagc gatcggagcg ggtgcattaa accaggctgt aaaagctgtg 1682401 gcgattgcca ggggatttgt ggcgccaagc ggcgttgatt tgatttgtat tccggctttt 1682461 acagatattc aaatcgatgg ggaagaaaga acagcgatta aattaatcgt ggagcctcgc 1682521 taaaaacaaa taaagcattc tcaacctgtt tgcgtaatgc aaacaggttg tttttcattt 1682581 attgtgatat tttctcccga tagtattttt agcacataaa tgagcgaata tacaaaatca 1682641 gaaatgagct aaaacgtttc aaaaaaaatt tccgcccatt tttcaagaca gatacttttg 1682701 tccttctgga aaagacagtt ctgtttacgc ttattccata tcatggtaca atccgaatat 1682761 aacaagaatt tttcaaggag gattgtacat gcagagtgga aagatgaaag ctctaatgaa 1682821 aaaggacggg gcgttcggtg ctgtgctgac tgaagttccc attcctgaga ttgataaaca 1682881 tgaagtcctc ataaaagtga aagccgcttc catatgcggc acggatgtcc acatttataa 1682941 ttgggatcaa tgggcacgtc agagaatcaa aacaccctat gttttcggcc atgagttcag 1683001 cggcatcgta gagggcgtgg gagagaatgt cagcagtgta aaagtgggag agtatgtgtc 1683061 tgcggaaaca cacattgtct gtggtgaatg tgtcccttgc ctaacaggaa aatctcatgt 1683121 gtgtaccaat actgctataa tcggagtgga cacggcaggc tgttttgcgg agtatgtaaa 1683181 agttccagct gataacattt ggagaaatcc cgctgatatg gacccgtcga ttgcttccat 1683241 tcaagagcct ttaggaaatg cagttcatac cgtactcgag agccagcctg caggaggaac 1683301 gactgcagtc attggatgcg gaccgattgg tcttatggct gttgcggttg caaaagcagc 1683361 aggagcttct caggtgatag cgattgataa gaatgaatac aggctgaggc ttgcaaaaca 1683421 aatgggagcg acttgtactg tttctattga aaaagaagac ccgctcaaaa ttgtaagcgc 1683481 tttaacgagt ggagaaggag cagatcttgt ttgtgagatg tcgggccatc cctcagcgat 1683541 tgcccaaggt cttgcgatgg ctgcgaatgg cggaagattt catattctca gcttgccgga 1683601 acatccggtg acaattgatt tgacgaataa agtggtattt aaagggctta ccatccaagg 1683661 aatcacagga agaaaaatgt tttcaacatg gcgccaggtg tctcagttga tcagttcaaa 1683721 catgatcgat cttgcacctg ttattaccca tcagtttcca ttagaggagt ttgaaaaagg 1683781 tttcgaactg atgagaagcg ggcagtgcgg aaaagtaatt ttaattccat aaagggggat 1683841 aaacatgacg aaggaatttg agtttttaaa agcagagctt aatagtatga aagaaaacca 1683901 tacatggcaa gacataaaac agcttgaatc tatgcagggc ccatctgtca cagtgaatca 1683961 ccaaaaagtc attcagctat cttctaataa ttacctcgga ttcacttcac atcctagact 1684021 catcaacgcc gcacaggagg ccgttcagca gtatggagcc ggcaccggat cagtgagaac 1684081 gattgcgggt acatttacaa tgcatcaaga gcttgagaaa aagctggcag cctttaaaaa 1684141 aacggaggcg gcacttgtat tccaatcagg cttcacaaca aaccaaggcg tactttcaag 1684201 tattctatca aaagaggaca ttgtcatctc agatgaattg aaccatgcct ctattattga 1684261 cggaattcga ctgacaaagg cggataaaaa ggtgtatcag cacgtcaata tgagtgattt 1684321 agagcgggtg ctgagaaagt caatgaatta tcggatgcgt ctgattgtga cagacggcgt 1684381 attttccatg gatggcaaca tagctcctct gcctgatatt gtagagctcg ctgagaaata 1684441 tgacgcattt gtgatggtgg atgacgccca tgcatccgga gtacttggcg aaaacggcag 1684501 gggaacggtg aatcacttcg gtcttgacgg cagagtgcat attcaggtcg gaacattaag 1684561 caaggcaatc ggagtgctcg gcggctacgc tgcaggttca aaggtgctga tcgattattt 1684621 gcgccataaa ggccgtccat ttttattcag cacatctcat ccgccggcag tcactgcagc 1684681 ttgtatggaa gcgattgatg tcttgcttga agagccggag catatggagc gcttgtggga 1684741 gaatactgcc tattttaaag caatgcttgt gaaaatgggt ctgactctca cgaagagtga 1684801 aacgccgatt cttcctattt taataggtga tgaaggtgtg gcaaagcaat tttcagatca 1684861 gctcctttct cgcggtgttt ttgcccaaag tatcgttttc ccgactgtag caaagggaaa 1684921 agccagaatt cgcacgatta taacagcaga gcacaccaaa gatgaactgg atcaggcgct 1684981 tgatgtcatc gaaaagacgg caaaggagct ccagctattg taacaagagg aagagtttac 1685041 tcttcctctt ttgattcctt attgattatt attctcaatg agtgtacaat gataggttgc 1685101 cagttgtgca gagcttcaat aacctttata ctgaagggtg gaagtttggt ttgaaaggag 1685161 aaaatatgac atgaatgaaa aacaaaaatt agagagcgga caagttcatc catcggacaa 1685221 aaaatccgag aaggattaca gcaagtactt tgaagctgtt tacattccgc cttctttaaa 1685281 agacgcgaaa aaacgaggca aggaagccgt tacttatcat aatgacttta aaatttctga 1685341 acaatttaaa ggattgggag acggaagaaa gttctatatc cgtacgtacg gctgccaaat 1685401 gaatgaacac gatacagagg ttatggcagg gatctttatg gcgctcggtt acgaagcgac 1685461 aaactctgtt gacgatgcca atgtcatttt gttaaataca tgtgcaatcc gtgaaaatgc 1685521 tgaaaacaag gtgtttggtg agctcgggca cttaaaagca ctgaaaaaaa acaatcccga 1685581 tctgatttta ggcgtgtgcg gctgtatgtc ccaagaggaa tcagtcgtga accgtatttt 1685641 gaaaaaacat ccgtttgtcg atatgatttt cggaacgcat aacattcatc gcctgccgga 1685701 gcttttgtca gaagcatacc tttcaaaaga aatggttgta gaagtttggt ctaaggaagg 1685761 ggacgttatt gaaaaccttc caaaagtccg aaatggaaaa attaagggct gggtcaatat 1685821 catgtacggc tgtgacaaat tctgtacgta ttgcattgtg ccttacacac gcggaaaaga 1685881 aagaagccgc cgccctgagg atatcattca ggaagtgaga aggctcgcaa gtgaaggcta 1685941 taaggaaatt actctgttag gccaaaacgt aaacgcgtat ggaaaagact ttgaagatat 1686001 gacgtacgga cttggtgatt tgatggatga actgagaaaa atcgatatcc cgagaatccg 1686061 ttttacaacg agtcatccgc gcgactttga cgaccgcctc attgaagtgc tggcaaaagg 1686121 cggaaatctg cttgatcaca ttcatcttcc ggttcaatca ggaagctcag aagttctcaa 1686181 gctgatggcc cgcaaatatg acagagagcg ttacatggag ctggtgcgaa aaattaaaga 1686241 agcaatgcca aacgcttctt tgacaacgga cattatcgtc ggatttccaa atgaaacgga 1686301 cgaacagttt gaagaaacgc tttctctata ccgtgaagtg gagtttgaca gcgcctatac 1686361 gttcatttac tctccgcgtg aaggcactcc ggctgctaag atgaaagata atgtaccgat 1686421 gcgtgtgaaa aaagaacgcc tgcagcgtct aaacgcactg gtgaatgaaa tttctgctaa 1686481 aaaaatgaag gaatacgaag gcaaggttgt cgaagtatta gttgagggtg aaagcaaaaa 1686541 taaccctgat attcttgctg gctatactga aaaaagcaag cttgtcaatt tcaaagggcc 1686601 gaaggaagcc atcggcaaaa tcgtccgcgt gaaaatccag caagcgaaaa catggtcgct 1686661 tgacggagaa atggtaggag aagcaatcga ggtgaaatga gatgacgctc tactcaaaaa 1686721 aagacattgt gcagcaggct cgaaaccttg caaaaatgat ttctgaaaca gaagaggttg 1686781 attttttcaa acgggctgaa gcgcaaatca atgagaatga caaagtgtcc acaatcgtta 1686841 atcagattaa agccctgcaa aagcaggctg tcaatctgaa gcattatgaa aagcatgaag 1686901 cgctcaaaca agtagaagca aaaattgacg cgctgcaaga agagcttgaa gagattcctg 1686961 ttatccagga attcagagac tcgcaaatgg aagtaaatga cctactgcag ctcgttgcac 1687021 acaccatttc caaccaagtc acaaatgaaa tcatcacatc aaccggaggc gacctgctga 1687081 aaggggaaac cggttcaaag gtgaagcatt caaataacag ctgttctctc taaacacggt 1687141 gcctttacag gcccgtgttt ttttatcatt tgtgcggtta aaaatgaact aaataatcta 1687201 tgtaccaaat gttcaattgg tttttctgtg ctcagccgcg tataaacttt atcgcactta 1687261 taagtaaagt ttctaggcac ccctgcatac aatggaacag aaactttgta tttttatatt 1687321 ttatttataa aaatgcacac tagacaaatg cccagcataa gataacacga agaagaacaa 1687381 ggaggcatgc cggaatgtct gaatacaggg aaattattac gaaggcagta gtagcgaaag 1687441 gccgaaaatt cacccaatgc accaacacca tctcgcctga gaaaaaaccg agcagcattt 1687501 tgggtggttg gattattaac cacaagtatg acgctgaaaa aattggaaaa acggtagaaa 1687561 ttgaagggta ttatgatata aacgtatggt actcttacgc ggacaacaca aagacagagg 1687621 ttgtcacaga acgggtaaaa tatgtagatg tcattaaact cagatacaga gacaataatt 1687681 acttagatga tgagcatgaa gtgattgcca aagtgcttca gcagccaaac tgccttgaag 1687741 tgaccatttc gccgaatgga aataaaatcg ttgtgcaggc agaaagagaa tttttggcgg 1687801 aagtggtagg ggaaacaaag gtagttgttg aggtcaatcc tgactgggaa gaggatgacg 1687861 aggaagattg ggaagatgag cttgatgaag agcttgaaga catcaacccg gagtttttag 1687921 tgggagatcc tgaagaataa aaaagggact aggggagaca gtacccccaa gtctcttttt 1687981 tatattgata tatcattctt ttatcacttt ttgtttatgt tataatgaag gttggaaaat 1688041 agaaacgttg atacatagtg agggattaaa caatggccgg ttatacgcct atgatacagc 1688101 aatatttaaa aataaaggca gagcaccagg atgccttttt attttttcgc ctgggtgatt 1688161 tttatgaaat gttttttgag gacgccaaaa aagcgtcaca agagctggaa attacgttaa 1688221 cgagcagaga cggcggtgcg gctgaaaaaa taccgatgtg cggtgtgccg tatcattctg 1688281 cttccgcgta tatcgaacag cttattaaaa aaggatacaa agtggcgatc tgtgaacaga 1688341 cggaagatcc gaaagccgca aagggcgttg tgaaaagaga agtagttcag ctgattacgc 1688401 ccggaactgt aatggacggc aaaggcatcc atgagtcgga aaataatttt atcgcatctg 1688461 tttcagcctg ctcgaacgga tacggacttg ctctgtctga tttaacaacg ggagaaaatt 1688521 tggctgtttt gattgaacgg cttgaagacg tcatatcaga aatttattca gtcggcgcac 1688581 gggaaatcgt ggtttcagga agcttggatg ccgatacagt ggcacagctg agagagcggt 1688641 gcggtgcaac gatttcaatt gaagacggag aaacagacga acacgtaacg atcattgagc 1688701 acttaaataa tgaagatata acaaaaacat ttctgcgctt atatacgtat ttgaaaagaa 1688761 cccaaaagcg cagccttgat catcttcagc ccgtgcaggt gtatgagctt gaggaagcga 1688821 tgaaaattga cttgtactca aagcgtaatc tggagctgac cgaaacgatt cgttcgaaaa 1688881 ataaaaaagg ctcccttttg tggctgctgg atgaaacaaa aacggcaatg ggaggccggc 1688941 tacttaaaca gtggattgac cggccgctta tcagagtcaa tcaaatcgaa gagcgccaag 1689001 aaatggtgga aacattaatg tcccatttct ttgaacggga agatctgcgt gaacgtttaa 1689061 aagaagtata tgacttagaa cgccttgccg gccgcgttgc attcggaaat gtcaatgccc 1689121 gggatttgat tcagctgaag gaatcgttaa agcaagtgcc tggcatcaaa cagctggttg 1689181 cttcactggc tcatgacaag gccaaggaac gtgcaaagcg cattgaccct tgcggggatg 1689241 tacttgaact gctggaagaa gcgctgtacg aaaaccctcc tttatcggta aaagaaggga 1689301 acctgattaa agatggttat aatcaaaagc ttgatgaata tcgtgatgca agcagaaacg 1689361 gaaaagactg gattgcccgc ctggaacagc aggagcggga atacacaggc attcgctctt 1689421 taaaggtcgg ctttaataaa gttttcggtt attacattga agtgacaaaa gcaaacttgc 1689481 atttgcttga ggaagggcgt tatgagcgga agcagacgtt aaccaatgca gagcgctaca 1689541 ttacacctga attaaaagaa aaagaagcgc tcattttaga ggcggaaaat aacatctgtg 1689601 agctggagta cgagctgttt accgagctgc gcgagaaagt gaagcagtat attccgcggc 1689661 tgcagcagct tgcaaaacag atgagcgagc tggacgcact gcaatgcttt gcgacaatca 1689721 gtgaaaatcg ccactacacg aaaccagagt tctctaaaga tgaagtcgaa gtgattgaag 1689781 gcagacaccc ggttgttgaa aaagtcatgg acagccagga atatgtcccg aacaactgta 1689841 tgatgggcga taacagacaa atgcttctca ttacaggtcc aaacatgtca gggaaaagca 1689901 cgtatatgag acaaatcgcg ctcatttcca ttatggcgca aatcggctgc tttgtacccg 1689961 cgaaaaaagc ggtgctcccg attttcgatc aaatttttac gcgaatcggc gctgcagatg 1690021 atttgatttc cggacaaagt acatttatgg tagaaatgct tgaagcgaaa aatgcgattg 1690081 tcaatgcgac gaaaaacagc ctcattctgt ttgatgaaat cgggcgggga acgtccactt 1690141 atgacggcat ggcgctggca caggcgatta ttgaatatgt tcacgatcat atcggcgcca 1690201 agacgctgtt cagcacacac tatcacgagc tgaccgttct tgaggacaag ctgccccagc 1690261 tgaaaaacgt tcatgttcgc gctgaagaat ataacggaac ggttgtcttt cttcatcaaa 1690321 ttaaagaagg tgcggctgat aaaagctatg gtatccatgt agctcagctt gccgaactgc 1690381 cgggagatct gattgcgcgc gctcaagata ttttaaaaga gcttgagcat tcaggaaaca 1690441 aaccggaagt gccggtgcag aaacctcagg tgaaagaaga gccggcacag ctgtcctttt 1690501 ttgacgaagc ggaaaagccg gctgaaacac caaagctttc aaaaaaagaa aagcaagtga 1690561 tcgatgcttt caaatcactt aatatactgg atatgacacc gcttgaagcg atgaatgaaa 1690621 tgtacaagct gcaaaagaaa ttacattaaa acggggtgat gaatgtggca aaagtcatcc 1690681 aactgtcaga tgagctttca aataaaatag cggcgggcga ggttgtggaa cggcccgcct 1690741 cagtcgtcaa agaattggtg gaaaatgcga tcgacgctga cagcacagtc attgaaatcg 1690801 atattgagga agcaggcctt gcatccattc gggtcttgga taacggcgaa ggaatggaga 1690861 atgaagattg caagcgagct ttccggcgcc acgcaacgag taaaataaaa gatgaaaatg 1690921 atttattcag ggtgagaacg ctcggtttca ggggagaagc cctgccgagt atcgcgtcag 1690981 tctctcatct ggagattaca acaagcactg gtgaaggagc tgggacgaag ctcgtcctcc 1691041 aaggaggaaa catcatttcc gaatcgcgtt cctcaagcag gaagggaact gaaattgtcg 1691101 tttccaacct gttttttaac acaccggccc gtttgaaata tatgaaaacc gttcatacag 1691161 agcttggaaa cattacagat gtggttaacc gtattgctct ggcgcatcca gaggtatcga 1691221 tccgcctgcg ccatcatggg aaaaacctgc ttcaaacgaa cggaaacgga gatgtgcgcc 1691281 atgtactggc agcgatttac ggcacggctg tcgccaaaaa aatgcttccg ctgcatgtga 1691341 gctccttgga ttttgaagta aagggatata tcgccctccc agagattaca cgggcgtcga 1691401 gaaactatat gtcgtctgtg gtcaatggcc gttacattaa aaatttcccg ctcgtcaaag 1691461 cggttcatga aggctatcat acgcttctgc cgatcggacg ccatccgatt acttttatag 1691521 aaattacgat ggacccgatt ttagtcgatg tcaacgtgca tccatcgaag cttgaggtcc 1691581 ggctcagcaa ggaaacagag cttcatgact taatacgtga cggaattaaa gatgtgttta 1691641 aacagcagca gctgattcct agtgcccagg tcccgaaaaa atcagcacct gccatcaaaa 1691701 atgagcagca gtttataacc tttgatgaaa agcctccgga aaaaaaagtt ccggaaaaat 1691761 cgactgcgcc atcttattca ccgatgaagc tcagctcagt cgtaaaagag ccggttgatg 1691821 cggaggaaaa attgccccct ctccaatttg atgctcctcc tatcgttgat caggaacaaa 1691881 cccttgaggt gtccgatgtt tcagcagaac agcctgaaac atttgagcag gaatgccatg 1691941 aggaacagcc gcagccagcg tctgatcggg ttccaattat gtacccgatt ggccagatgc 1692001 acgggactta tatattggca caaaacgaaa acggcctata tattatcgac cagcacgccg 1692061 cccaagaacg tattaaatat gagtacttcc gtgaaaaggt gggggaggtt gagcctgagg 1692121 tgcaggagat gattgtaccg ctgacgttcc actactccac aaatgaggct ttgattattg 1692181 aacagcacaa acaagagctc gaaagcgtcg gtgtcttttt agagtcattc ggctctaaca 1692241 gttacatcgt ccgctgccac ccagcctggt ttccaaaggg agaagaagca gagcttatag 1692301 aagaaatcat tcagcaggtg ctcgactcca aaaatataga tattaaaaaa cttcgcgagg 1692361 aagcggcgat tatgatgagc tgcaaaggct ccatcaaagc aaatcgccac ctcagaaacg 1692421 acgaaatcaa agcgcttctg gacgacctcc gaagcacatc agacccattt acatgcccgc 1692481 acggccgccc gatcatcatt caccactcga catatgagat ggaaaagatg ttcaaacgcg 1692541 tgatgtagcg ggggtggtag gcattgatcc attctctgaa tggatcaatg ctttttttgt 1692601 actccttcga gtgtcagatt ataagaaacg gttgtaaacg tgtgagcagt gttaacgcat 1692661 tatacttcat ggttcctccg tataacaaaa tttccattta caggcaattg ggattaatgt 1692721 atattttggg tgagggggtg gaaacatatg gcatgtggtc cgaagatcat tatctttttg 1692781 gatgaacttg atgatccaaa tgtgagaatc attttagaat gcagaattta aattacaaca 1692841 ttgtgttttg ctccctgttc gtgtgaacag ggagattttt tcgtttatat aactggtgat 1692901 gtccaaatat agggtgttat gaattttcca tatctgccat cggctttaag ctgcttctct 1692961 attaggctgg ttatcaaaag caagttcaat gatagccatg aaagctgata tcacaacaag 1693021 caagacatct ggaatataaa tagactgcat aaagtaatct gcaaaacaga tcgttataag 1693081 attgctgata aaatacagta taaaagcaaa aagtgcagtc tttttcaatg aaagtgattt 1693141 tgccaaaatg atagagataa tctttgtgag tgggtctatg attaaaccta cagcaaagca 1693201 ggctaaaata aataaagcta atgtttgatt ggaagcgtat gtgatgccaa gtatggagaa 1693261 taagcctttc atcccgaaga aaaagccgcc gaagatgact gcaagcgcga tggccgcgat 1693321 aaaagtaata gatacaattc cgattaattt tgatctcagg ttaaaatctt tagagtgctc 1693381 gttctgttct ttttggttca tgtatgacac tcccttcacc tgcttactca tacaaacagc 1693441 acccttgaat cagcccaaaa tatctataag tctgttttct gacgaaaata gtatagcata 1693501 ttttaacaaa accaaaaaag gccctttcca ctggggaagg gcctttttca tcatgttaac 1693561 tcctgagatt cgccgaagct ttctcttttt ttggccaaat aaaatagctg gctgtaatga 1693621 gaaagtcaat gcctataatg acagtccaca gtttaagaat gccgctcaac gcctcggttc 1693681 gggaagagtc attgataaaa tagatcatcc ctgccaatag tcccgcacca attaagtagg 1693741 ccagcacatg tcttagccag cctttcgcac cgtgcttggc atggtccatt ccaaaacgtt 1693801 tcagcggttt tgttcctttt tttgtcacat aatattgaaa cttttcatct gcccattgaa 1693861 tcatttgttt cccataagcg atcgatatac cgatgtaaac agctgcaatc ccatgggctg 1693921 cggtcgctga ggctccgcgg taaaggtcca caccagttgc cgctaacaag atcaaatcga 1693981 taactggagt taaggcaagg aatagcagtc ctaatgtatg tcgtttgaat acgtagcgta 1694041 cagcaagccc caaaacaatg acaacccaaa acgcaatttc acagaaaaca atcatccatg 1694101 cgataccgtt caatccattc ccctcttttc aatacagttg tattatttaa ataatatgtt 1694161 accatctttg tttttgtaac acaactgtat tataaaaatt gccccgcctt tgaacgaaag 1694221 ctcaaaggcg ctacgctgta ttattttgat gaaagtggct gtcagctgtg ctggatatca 1694281 attgtatata ctgcacgatc tgttacgacc ttcaatcctt cgttttcttg gtgaatatga 1694341 agctcaccta ataaaggaat ctcataggca ttttgcggaa gcggtacgtt tccgtcctca 1694401 gtgaatgttg ttccttcgcc ttctaaaaca agctcttctt tcgcaacata atcatcagga 1694461 tgattcgtac tgcgtatagc cactttttga aggtggagaa caatctgatc caagtctgat 1694521 atctcttcat catgggtcaa ttcacctttt ctaatatcaa gcgtctggcc gacttttgat 1694581 tccagccatt gagaaagctg tgtattcgtg tgtgccatca atattcctcc ttttgatcta 1694641 cacgatacta ttcccaattg ctgcatcttt tacacgggaa agagccgccc cactctttat 1694701 gtatgaaaca gttcgctgtt gagtgccttg atatagcgta cggcagaacg ctggaccgat 1694761 tcgtcggcat tttctttgac aactttagag aaagcattgt aaagccggtt gaattgaagc 1694821 ggttttactt tggctgctat ttcttcaact ttggaggcgg gaaggggaat gagatttggg 1694881 tagctgtaca taaagctgac ccagtttcga tccgccgcaa ccgtaatgat atctccggtc 1694941 aatagacagc ctttcccttc attgcccttg ctccaatgca aaacagcacc gcctttaaaa 1695001 tgtccgccca gtcggtaaag gtccagtccc ggcttcatat tgagcgtttc ccctgaccag 1695061 aagtgaatgt gattgcttgg ccttgtcacc cattctttat catcctcatg gatatagatc 1695121 ggcgcctgaa acgcttcagc ccactcaacc tgagtagagt aataatgtgg atgagacaag 1695181 gcgatggctt gaataccgcc taattcgttg atttggtcaa ttgtcttttg gtcaagatat 1695241 gtcatgcaat cccacagcac attgaagccc ttatgctgaa taagatgggc tgtttgtcca 1695301 atcgcaaact ctggttcagt tttgatgctg taaagatgct cttcttcctt tttaaggatg 1695361 ttttgaaggt ttcctttctc acgcatgtct tcaagggttg tccaagtttg tccatcggga 1695421 tgaatatact gtctttcatc ctcgcaaatc agacacgagt tgggcggatc tacagtctgt 1695481 gcatgttgca caccgcatgt attgcagata taatatggca ctttcttcac ttccttcatc 1695541 tattttccat tattttacct tatgattatg aatattcaaa cgaaaaaacc ggcagttctg 1695601 ctgagagaga attgccggct tttgatgatg tttattggcc gggaacggaa ttttctgcgt 1695661 tgacagcgcc cgctccgtag atattcggat cttcatcttt ccatttgtcc gtgccgtttt 1695721 tcaaaagctc ttttacttca tcaggggtaa gatccgggtt ttgctgaaga attaaagctg 1695781 cgattcctgc gcaaatcggt gttgccatcg aggttcctga cattgtaaag tactgagacc 1695841 ctacacggct tgacttttgg agcttatcaa tataagaatt cggagagcga agggaaataa 1695901 tattaacacc cggcgctaaa atatcgggct tttctttccc gtatactgtc gggccgcggc 1695961 ttgagaagga agcgacagta tcatcatcgc tgcttgcagt attgttatcg tcaagcgcac 1696021 ctactgtaat caccttttcg ctcacgcccg ggcttgcaat ggtctgcgaa tcagggcctg 1696081 agtttccggc agcgacacag acgacaatcc ctgcgctcca cgcttcctca accgctctga 1696141 ctaacggatc ttcctgttca tgatcatatc taagggcatc gcccccgagc gacatgctca 1696201 taatatcaat cggttcatcg gggttgtcct cattgtattg aatacaccac tcaacaccct 1696261 ctataatatc tgctaacgtt cctgaaccct gcttgtttaa tacctttacg ccgatgagat 1696321 tggcttccgg tgcaggtccg cggtattgac cggaagagga tgcaccgctg cttgcgacat 1696381 cacctgcaca gtgtgtgcca tgaccattat catcgtacgg ctctgttttt tgattgacca 1696441 tgtccgcgaa tccgataatt cttccttcta gatcaggatg cgggtagatt cctgtatcga 1696501 caacagcgac agtaacacct tttcctgtca gggtttgccc gtttctgacg acttccttcg 1696561 catggcttgc ttcggttgcc gtgtctaaaa gcgctttgac ttcgcggttt aaatacactt 1696621 tacggatatt gctgcattca gagagaaggg aatgtaatgc tgaaggagta acctcggcgc 1696681 tgcagcagtt gattttgttg aagcggcttt ttagcttgct gcgtttttct ttttgcagca 1696741 cctctccagc catttgaaag ccggtctcgt gacagccttc ctcaaattcg ataatgactg 1696801 acattttttt tctgttttgc aatttggttt cgaaaaattt atgcaagaag caaggagtcc 1696861 atttgaaggg cttgtaaagt tgcaatacgg tttcccgtaa cggccaatct agcttgtgag 1696921 catttgctct caccatttgt accatagagt acccaaacat gtattttcct cctattataa 1696981 ggttctctgt atactctatg aacagatgat aggtttggta agtttgtttg tcctctgtaa 1697041 gagacagaca agagtttgtt tttctgaatc tttcgcatta gatacgatag attcagaagc 1697101 tgaggaaatc attggggatt gaaaaagaac gtttgttcgt attataatgt gatcatatca 1697161 aactgggaag gggagagcaa ccgtatgaat ttctacttgc accgatcttt ggaaagccaa 1697221 atgccaatca gcattatata tgaagaaaga cggaacgatt agtaaaagaa cgattattgt 1697281 gagacagaaa agcaaaacga aaatcaaagc attttgtttt tcgaaacaac agatcagaac 1697341 atttttattg gactctatcc tctcctgtga ttttgtgaga acaaataagc aaaatctcta 1697401 ttctgcaggc cggtaacagc tgtccgtctc agcaaccggg cagcctgtta ctaaaaccct 1697461 ccttaaacct atatacattt atttgccaag tgaggttgtt cctacctttt ttgtctttcc 1697521 tctcaacctt ttttcactct tatttgaaat gaaccgctaa taaccgtgac aatcaattga 1697581 ttttttgaaa ccgggaactt tttcactgat gatattgtgt atacaatggt aagataaaac 1697641 ctattggcta aacctcatat aatgaaccgc gccattctta tgaaaggagt taaacatgag 1697701 aagattttta ctaaatgtca tattagtctt agccattgtc ttgttcttga gatatgttca 1697761 ttactcattg gaaccagaac catcaaatca gccagataca tattcaaatt tcagcagctt 1697821 ggcagagaat gagagcccag ccgattacga tatttcatat aatgagaaaa aaggaagcaa 1697881 agtcttaatt atgtctccgc atggcggaag aattgaaggc ggagtaagtg agcttgtgcg 1697941 ttatttcaat aatgaatact ctacatacct atttgaaggg ttgaagtccc atgataacca 1698001 aacactgcac attacaagca ccaactttga tgagccattg gcaaaaaaga aaatcaagga 1698061 gcatcaatat gtggtggctt ttcacggata taaaggagag aacaagaata cccttgtagg 1698121 gggaacagac cgaaagcggg cgaaaatgat tgtgagagcc cttgagcgga gagggttttc 1698181 cgctgagtta gcgtcgtcta aaagcggtct tgctggattg aatgccgaaa acattaataa 1698241 ccaaggggaa acggggctaa gtatccagct ggaaatcagc cgtgagcaga gagaagcatt 1698301 ttttgatgat ttttattata aaaatagaaa atacacaaag aacagtgaat tttatgctta 1698361 tgtcagtgcg atcaaaggtg tcctggaaaa agagtattcg taacaagcag atcagaagac 1698421 aaaataagag aagatcagta gactgaaata ggataaaaaa ggaggcaaaa caatggcaga 1698481 tcatcatttt tatttaaaag cgaactggcc gggtaaccgt aatgatgtcg gtacgatcga 1698541 aagcggaaac ctgatcacat cgatttccat tcctaaagaa atggatggcc cgggagaagg 1698601 gaccaaccca gatgaaatgc ttctcggggc ggcagcgacc tgttacatta ttacacttgc 1698661 agcgatgatg gagagaagcg ggctggaaaa agaagactta cagatggagt cagaaggcat 1698721 tgtcaacgtt acaaaaggag tctttacata caaaaagatc attcaccgtc cctctgtcgt 1698781 gcttaaacat gatgcttcac aagacgacgt cgcattggcg cacaaacttt gtaaaaaagc 1698841 ggagtcgtca tgcatgattt cgcgtgcaat tcaaggaaat gtcgagctgc agcttgaagc 1698901 ctctgtgaaa ctgggtggag aataaagaaa acagacggtc actcacaggc cgtctgtttt 1698961 ttatcttcag cgtgggcttt cgattgattt agcacgacca cgcctgcaat gacaagcgtg 1699021 agaccgaata caccttttaa actgatggtt tcgccaaaaa gcaaaaaccc gacaattgct 1699081 gtaagcgcgg taccaacgcc cgaccatgtt gcatacgcgc ttgataagtc aattgttttt 1699141 aaagaaaagc ttagaaacgt aaaagcagaa agaaatccga ctatgactcc ggcaatgggc 1699201 caggcttgtg taaatccttc tgaaagcttc aacatcgtgc tcccaaacac ttcagataca 1699261 atggcgagag ccaaataaag caatcctctc atcttcatca ctcctttacg gccaattaag 1699321 taacacgacc cctgatagta ataaaagaat cccgataagc cctttggcat tcagatcttc 1699381 cttgaaccat tttactccga tcactgtcgt cagcaccgtg cctgccccgc tccaagtcgc 1699441 ataggagagg ctcaggggaa tatggtttaa agtcagggac agcatataaa aggcgaggga 1699501 atagccaata acgaccaaag cacttggctt ccactttttg aagccatcag atactttcag 1699561 catggctgct cctatcgatt ccgaacatat ggcaatcgtg aggaatatat atcctatcaa 1699621 catcatgaat tctcctcact atatttttag attagaaaaa aaacttcagc tagaaaaata 1699681 ttagtgtatg cctatgtatg agtcaagaga ttcattttca cacacttaaa aagacccctt 1699741 tttaaggggt cttttgcgtt taataataaa aagggaacgg ggcatacgga taataggggt 1699801 atccgccata caaataagga ttaaataaag cgcttcctat aagcccgcct gcaaggccgc 1699861 cgataaacgg tcctccaaaa aatccgaatg gccggccaaa cccataacca aatccgggtc 1699921 ttccaaaccc gtaaccgaac ccgaacggtc ttccaaaccc aaatggtctc ccgaatccga 1699981 acggccttcc aaatattctt gtatcttcag ggctgaaatg ctctaactcg ttcatgtttt 1700041 ctttcctcct gtaataaagt gtagatgatg cagtgtattc accctgcccg gatttgattg 1700101 ggcgaatcga ggaaaaggag gatgtgaaca cattgggcct gtatcagtct gactggtcaa 1700161 aagcaccgcc ccacgcacat gcttatcatg tcaaaacaac gagagaacag ggccattatc 1700221 atctcatcga agggtttact cagccggcaa acggatcaaa taccgatcag catacacatt 1700281 actatacagg gatcacttca tttgaaaacg gccattttca tcggtattac ggaatctcag 1700341 gaccggcgat tcccttagca gatggcacac attatcatga aatcgaagaa acgacgtatc 1700401 tggcctataa cgagccgatt gagatccagt acggaggggt tgtgtacgat cccggagatg 1700461 acagaagaaa aacgcatcgt cataccctga aaggaaagac aagggaaatt gtcggcaatg 1700521 agccgctcgg ctggtagaag gatgtttacc gatgcaaaaa aagggcaaaa tggataggtg 1700581 gttgtccatg ttgaatgcta taatgggggg agatttataa aagagagtga tacatattga 1700641 ataatacgaa gcagcccgtt gtcattttag tcggaccgac ggcagtgggg aaaaccaatt 1700701 taagtattca gctagccaaa tccttaaacg cggaaattat cagcggagat tcgatgcaga 1700761 tttataaagg gatggatatt ggaacagcta aaattaccga acaggagatg gagggagtgc 1700821 cccatcatct gattgacatt ttagatcccc aagactcttt ctctactgcc gattatcaaa 1700881 gcttagtaag aaataaaatc agcgagattg caaatagagg aaagcttccg atgattgtcg 1700941 gcggtacagg gctttatata caatctgtgc tttacgatta tacatttacg gaagaggcaa 1701001 atgatcccgt gtttcgagag agcatgcaaa tggctgctga gcgggaaggc gctgactttc 1701061 ttcatgccaa acttgctgca gcagatcccg aggcagcagc tgcgattcat ccgaataata 1701121 caagaagagt cattcgcgca ctggaaattt tacatacgtc cggaaaaacg atgtcccagc 1701181 atttgaagga acaaaaacga gaacttctgt acaatgcagt gttaattggc ctgacaatgg 1701241 atagagacac gctttacgaa agaattaatc agcgggtcga tttgatgatg cagtcaggcc 1701301 ttcttccgga agtgaaacgc ttatacgaca agaacgtgag agactgtcaa tcaatacagg 1701361 cgataggcta taaagagctg tatgcatatt ttgacggttt tgtgacactt tccgatgctg 1701421 tcgaacagct aaagcagaac tcgaggcggt atgcgaaacg ccagctgacg tggtttcgca 1701481 acaaaatgca ggtcacatgg ttcgatatga caccgcctgt tgatatggag ctgaaaaaaa 1701541 aggaaatttt cacacatata gcaggaaaac tcgaacttta atcgaaactg tatgatatag 1701601 agaatcaagg aggacgaaac atgaaaccga ttaatattca ggatcagttt ttgaatcaaa 1701661 tccggaaaga aaatacgtat gtcactgttt ttttgctgaa cggctttcag ttgcggggcc 1701721 aggtgaaagg ctttgataac tttaccgtat tgttggaatc ggaaggtaag cagcagctta 1701781 tatataaaca tgcgatctca acgtttgcgc cgcaaaaaaa cgtccagctt gaactcgaat 1701841 agatcaaaaa atgccatgtc aagacatgag gaaaggctgt cgggggttcc cggcggccat 1701901 ttttaacatg aatccacttt tgctccaagc tttttgtgta agctgaccat gccaaggcac 1701961 ggtctttttt tatgagaaca acatacggaa gtaaaaatgg tatattatgt ataaaatgaa 1702021 tttgggagtg atcgatcttg tttgaaagtg aagcagaact gagacgaatc aggattgcac 1702081 ttgtatggat agctgtcttt ttactgttcg gggcgtgcgg gaatcaagat accattattg 1702141 aaacagacaa cggcaattca gactatgaaa cgcctcagcc cacctcgttt ccacttgaac 1702201 ataaccattt tggcgttatg gaggacggct atatcaaaat ttatgagtat aatgagtccc 1702261 gcaatgaggt aaagctgaag aaagaatacg cggatgatga gcttgaataa aattcacaag 1702321 cattcgaatt tacaaagcgg atgccagccg ctaaactaaa tacagacaca gatcaaacag 1702381 agggtgaaaa catgaagcat aaagtgatcg tgaatcattg ggaagaaatt tgcgaagatg 1702441 attcttgcta tgaatacgga acaagtatca ttgtgaacgg aaaagaatta atcagagaag 1702501 cgtcaattat cactgctttg aaggcggttt tagaagagat cggcgcggat gttgaaatag 1702561 aagaaacagt agagagcgaa aaatgctgtg atagcttaag aaaaaaaaat ctagactact 1702621 aagcagtttt ttttcatgtt atgatataca tcggctaaaa acgacacccc gagtaggacg 1702681 agagatgatt ctcgttctgc tctctttttt gggccctaat gagtctgccc gtttgcctga 1702741 tttgatcaaa atatgaattt ttcataaaaa cgaatctata tattgtgttt ttgctagagg 1702801 gtagtatact atatatagtg ttagtgatga gagattcata ttttttgata ggtcgtgata 1702861 aaacgtggta caaatcatat ttgattcgaa aacagggaat gttcagcggt ttgtgaataa 1702921 aacaggcttt cagcagatac gcaaggtgga cgaaatggac cacgtggaca ctccgtttgt 1702981 tttggtcacc tacacgacaa acttcggcca ggtaccggca tcaacacaat catttctcga 1703041 aaaatacgcc catctcttat tgggagtcgc tgcgagcggc aacaaagtat ggggcgataa 1703101 ctttgcaaaa agcgccgata ccatttcaag acaatatcag gtgccgatct tgcacaaatt 1703161 tgaactcagc ggcacatcta aagacgttga attgtttact caggaggtag aaagagttgt 1703221 cacaaaatca agtgccaaaa tggatccagt taaataacga aatcatgatc caaaaagatg 1703281 ggaaattcca gtttgataag gataaagaag ctgtacatag ctattttgta gattatatca 1703341 atcaaaacac agtcttcttt cacaatttaa aagagaagct ggattatttg gttgaaaacc 1703401 aatactacga agaggaattc ttaagccttt attcttttga agacattaaa gaagtgttta 1703461 agacagctta cgctaagaag tttcgttttc cttccttcat gagtgcgttt aaattctata 1703521 atgactatgc tttgaaaacg aatgacaaga aaaaaatcct cgagcgttat gaggaccgga 1703581 tctcaattgt tgcgctgttc ttcgctaacg gcgacactga gaaagcaaaa gaatatgtaa 1703641 acctgatgat caatcaagaa tatcagccga gcacaccgac atttttgaat gccggcagaa 1703701 aacgccgcgg tgaacttgtg agctgcttct tgctcgaagt taatgattct ttaaatgaca 1703761 tttcaagagc aatcgatatc tccatgcagc tttctaagct tggtggcggg gtttctctta 1703821 acctgtccaa gcttcgcgcg aaaggtgaag ccattaaaga tgttgagaat gcgacaaaag 1703881 gcgttgtagg cgtcatgaag cttcttgata acgcgttccg ttacgctgac caaatgggac 1703941 aaagacaagg ctccggcgcg gcgtatttaa acattttcca ccgcgatatc aatgattttc 1704001 ttgatacgaa aaagatttct gcggatgaag atgtgcgtgt caaaacgctt tcgatcggtg 1704061 ttgtcattcc ggataagttc gttgagcttg cacgcgagga caaagcggct tatgtattct 1704121 acccgcacac gatttataaa gagtacggcc agcacatgga tgagatggac atgaacgaaa 1704181 tgtacgacaa gtttgtcgac aaccctcggg tgaaaaagga aaaaatcaac ccgcggaaac 1704241 tgcttgaaaa attggcgatg cttcgttctg aatcaggcta tccatacatc atgttccaag 1704301 ataacgtcaa taaagtgcat gcgaataacc atatttccaa ggtcaaattt tctaaccttt 1704361 gctctgaagt gctgcaggca tctcaagttt cttcatacac agactatgat gaagaagatg 1704421 aaatcggtct ggatatttcc tgcaacctgg gttcgcttaa cattctcaat gtcatggagc 1704481 ataaatcaat cgaaaagaca gtcaagcttg cgacagactc tttaacacac gtgtctgaaa 1704541 caacagacat ccgtaatgcg cctgctgtaa gacgggcaaa caaagcgatg aaatcaatcg 1704601 gcctcggtgc tatgaacctt cacggctacc ttgcgcaaaa cggcattgcg tatgaaagtc 1704661 cggaagcgcg tgactttgca aacacgttct ttatgatggt gaatttctac tccatccagc 1704721 gttctgcgga aatcgcaaaa gagaagggcg aaacgtttga tcaatatgaa ggatcaacct 1704781 atgcgacagg tgaatacttc gacaaatacg tttcaactga tttctcaccg aaatacgaaa 1704841 aaatcgctaa tctgtttgaa ggtatgcata tcccgacgac agaggactgg aaaaagctaa 1704901 aagcatttgt cgctgaacac ggtatgtatc acagctacag attatgcatt gcgccgacag 1704961 gctctatctc atacgttcaa tcaagcacgg cgtctgttat gccgattatg gaacggattg 1705021 aagaacgaac atacggcaac tcaaaaacgt actacccaat gcctgggctt gcatctaata 1705081 actggttctt ctataaagaa gcctacgata tggacatgtt caaggttgtg gatatgatcg 1705141 ccactatcca gcagcacatt gatcagggaa tcagctttac attgttctta aaagacacaa 1705201 tgacgacccg agatttaaac cgaatcgatc tgtatgcaca tcatagagga attaaaacca 1705261 tttactatgc aagaacgaaa gatactgggc aagacagctg cctttcttgt gttgtttgat 1705321 taaaggagag tttatagtga caaaaattta tgacgcagca aactggtcaa agcatgaaga 1705381 cgattttacc caaatgttct ataaccaaaa cgtgaaacag ttctggcttc cggaagagat 1705441 tgctttaaac ggcgatctcc tcacatggaa gtacctcgga aaaaatgagc aggacactta 1705501 tatgaaggta ctggccggac ttacgcttct tgacacagag caggggaata cggggatgcc 1705561 gatcgtggct gaacacgtag atggccacca gcggaaagcg gtgctgaact ttatggcgat 1705621 gatggagaac gctgtccatg cgaagtcgta ctctaatatt ttcatgaccc ttgcaccgac 1705681 tgaaacgatc aatgaagtat ttgaatgggt taaacaaaat aaatatttgc agaaaaaagc 1705741 gcaaatgatt gtcgggcttt acaaagccat tcaaaaagat gatgaaattt cactgttcaa 1705801 agccatggtt gcttccgtct atctggaaag cttccttttc tacagcggtt tctattatcc 1705861 gttatatttc tacggacaag gaaaactgat gcaaagcggt gagatcatta acctgatcct 1705921 tcgtgacgaa gcgattcacg gcgtgtatgt cggtctcctt gctcaggaaa tttataataa 1705981 acagacagaa gagaaaaaag cagagcttcg tgaatttgcg atcgacctcc tgaatcagtt 1706041 atatgaaaat gagcttgagt atacagagga cttgtacgat caagtcgggc tctcacatga 1706101 tgtaaagaaa ttcatccgct ataatgcgaa taaagcgctg atgaaccttg gatttgatcc 1706161 atacttcgaa gaggaagaca ttaatccgat cgttttaaac ggattaaaca caaaaacaaa 1706221 atcgcatgac ttcttctcta tgaaggggaa tggctataaa aaagcgacag ttgagccgct 1706281 caaagatgat gacttttatt ttgaagatga aaaagagcag atataatatc tgctcttttc 1706341 ggcttgaagg ttcaaatgag gaggacgcag tacccatggg aaaaatggac gaaatgattt 1706401 tagttgcccc gcgcgatgat gtgtttaaaa aagaaagctt aaccttccag ggcgtgtaca 1706461 gtgaagatag cagagtagca gaaatcatgg ctcagattga agcggcctat cgtgaaatga 1706521 gaagagggga cgcagaagaa gatccgcgtt tcaagcagcc gataccttat gtcgtcatta 1706581 agcgtgaaga tgaagttttt ctttacgagc ggctggctgg cggcggtgaa tcacgtctgc 1706641 acaacaagct ttctctcggt tttggcggcc atatgaacgc catcgaaggg gcagcttcat 1706701 ttgctgaagt cttaaagctg aacacagacc gtgagcttga ggaagaactg caaataaatg 1706761 aagaagataa acaggcgatt gtcacactgg gattgatcaa tgatgatgaa aacagtgttg 1706821 gcaaagtgca tatcggtatt ctttctgcgc ttcaattaaa gcctggcgca caagtggaag 1706881 tgaaggagaa agaacaaatt gcgggtaaat ggatgaaagt ttctgaatta aaacaggatg 1706941 atatctacaa ccgtctggaa acatggtcac agtttgttgt tgatattctt gaataaaaaa 1707001 acccggtttc tcgcgatgag gagccgggtt tttttatgag acgctcgtcc ccgtctcggc 1707061 tatgattcta ggatcacaat agcgtcaaag ccggcatttt tcgctctggc agcgagggtg 1707121 tctgcattgt ctttggatga aaatgcgcca atctgcactt tgtataatcc gtcctttaaa 1707181 aggacaatcg agtcaaaacc tttggcttcg gcattacttg cgagcgagtc ggcattcgct 1707241 ttgactttaa atgcgccgat ttgaacctta tataaccctg agctggaagt ctttttaagg 1707301 ttaaaggctt gctccagccc gtttgcatgt cctctcgcta agctttgaat aaaactgctc 1707361 gttttcagct tatttgcatc ggaaacggta tcaatgaagc cgttctcggt caagagggca 1707421 ggcattgccg actcccttag gacgtggaag ttcgctgttt ttttgccgcg atcggcaaag 1707481 tcgacagctt gtatcacttc agagtgaatt gtcgattgat aagtcgtcgt cggggctcct 1707541 acatctggat aaatatagct ttcaaaacct gtgcctcccc cggaattaac gtgaatggac 1707601 aaaaagaaat ctgctcccca gttatttgcg gcatttgtcc ggtcgtttaa gctgacatat 1707661 tggtcgcttg tccggctcag cagcagagaa acgccttcat attcattagt taatatcgta 1707721 cgtaaggcta aagcgatttg cagggttaac gttttctcct gaaggccatt acctgttgcg 1707781 cctggatcag acccgccatg gccaggatca ataaaaattt taaccatttt tcatcacctc 1707841 attacaggat atgaaaaaac acggcttctg cttgtacgat tatcattcaa ctgaaaaatg 1707901 aggaaataac cctttcacat ccagaaatta tttctcggga aagcgcacaa ttcaacatga 1707961 agcgacaaca gatacggtcc gacatgaaat ctgtgcatac gccatatgtt tgtatgtact 1708021 atgggttcgg ttaacctgca ctgattcctg ctggttttaa gctttgcgtt catattaaat 1708081 caagcattta aaacgtaaat tgatgaggaa agctcctttc attaaagaca ccgctttata 1708141 aatcgaaaaa aagaaaaaca cttcaggtat cttagggcgg gtaatacgtt tcgtacaaaa 1708201 atcagcccgt tgtatgaaaa agaaataatg agaaagaagc tcactataat actctgacaa 1708261 aatgattaaa aacaaaatct catggtttgt ccaccccatg tccgtgaata caataagaaa 1708321 taaagtattt ctcgggaaag cgcaggattc cttattgttc ccgaaaaaag caattgtttc 1708381 gacacatgat aggcgtttgt cacaatcggc atccgcttga atatcatata gagagaacag 1708441 agaggtgaag atgttggagc gcgctgtgac ttataaaaac aacggacaga tcaacattat 1708501 tctgaacggg caaaagcagg tgctgacgaa tgctgaggca gaggcggaat atcaggctgc 1708561 attgcaaaaa aacgaagcaa agcacggcat tttgaaggaa atcgaaaaag agatgagcgc 1708621 attagttggg atggaggaaa tgaaacgcaa catcaaggaa atatacgcct ggatttttgt 1708681 gaaccaaaaa cgcgcggagc aaggcttgaa ggttggaaag caagcgctgc acatgatgtt 1708741 taaaggaaat ccgggaacgg gaaaaacgac ggttgcacgg ctcatcggca agctgttctt 1708801 tgaaatgaat gtcctgtcaa aaggccactt aatagaagcg gagcgggctg acctggtcgg 1708861 ggagtatatc ggacacaccg cccaaaagac gagagattta atcaaaaagt cattaggtgg 1708921 cattttgttt atagacgaag cctactcgct ggcaagaggc ggcgaaaagg actttgggaa 1708981 agaagcgatc gacacacttg taaagcatat ggaagacaaa cagcatgagt ttattttgat 1709041 actcgccgga tattcacggg aaatggatca ttttctctcg ttaaatcccg gactccaatc 1709101 aagatttccc atctccattg attttccgga ttactctgtg acccagctca tggagattgc 1709161 gaaacgaatg atcgatgaaa gggaatacca gctcagtcaa gaagcggaat ggaaattgaa 1709221 agattactta atgacagtga aaagcacgac aagtcccatt aaattcagca atggacgttt 1709281 tgtcagaaat gtgatcgaaa aatcgatcag agcacaagcc atgaggcttt taatgggaga 1709341 ccaatactta aaaagcgact tgatgaccat caaaagccaa gatctttcca ttaaagaaga 1709401 agcatctgga tctgcataga cctctcagtt tttgagaggt ctgttttttg ctcgtatttc 1709461 cgcttttcaa agcaatcgat ttgtggtata cacatgcagg gtttggtatg ataatactac 1709521 tgcccaatat gcaaaagaaa ggaacatcca tttgaacgaa caagaaacga ttcaggagaa 1709581 agccatttta gtcggatgtc agctgccgca tatcacggat gagcattttg aaaattctat 1709641 ggaagagcta gcatctctga cgaaaacagc agacggaaaa gtactgacca gcgtcacaca 1709701 aaaacggaac agggctgacg ccgctacata tataggaaaa gggaaggtag aagagctgaa 1709761 ggcactcgtg gaagagcttg aagctgatct cctcatcttt aatgatgaac tgtcgccaag 1709821 tcagctgaag tcattggcaa cagcaattga agtgaagatg attgaccgca cgcaattgat 1709881 attagatatt tttgcaaagc gggcgagaac gagagaaggc aaacttcaaa ttgagctggc 1709941 tcagctgcaa tatgcactgc cgcgtctgac gggacaaggg atcaaccttt cccggcaagg 1710001 cggaggaatt ggggcaagag gtcccgggga aacgaaactg gaaaccgacc gccgccatat 1710061 cagaaatcgc attcatgaaa tcaacacaca gctttccact gtcattcgcc atagaagccg 1710121 ataccgtgaa agaagaaaga aaaacggtgt gcttcaaatt gcgcttgtcg gctatacaaa 1710181 cgcagggaaa tcaacatggt tcaaccgcct gacgagtgct gacagctatg aagaagacct 1710241 cctgtttgcc acgctggacc cgatgaccag aaaaatggtc ctgccaagcg gctacagtgt 1710301 tcttctttca gatacagtag gatttattca ggatcttccg acgacattga ttgctgcatt 1710361 ccgctcaacg cttgaggaag taaaagaagc ggatttaatt ctgcatttaa ttgattcttc 1710421 aaatgaggat tatgcgggac atgaaaaaac agtgcttcgg ctgcttgagg agcttgaagc 1710481 agatgatatc ccgatgctga cggcttacaa taaacgtgat caaaaactgc ctgattttat 1710541 accgaccgcc ggaagggatc acattatggt cagtgcgaaa tttgaggacg acgctgcagc 1710601 ctttaaagaa gcgattcagc gctatttgcg ccaagaactg ttaacgtctt ttgaagcaca 1710661 tgtgccggca agtgaaggga agctcctttc cagaatcaaa tcggaaacga tggtagaccg 1710721 cttctatttt aatgaagaaa atgaacagta tgacatatcc ggctatgtcc aagaagagca 1710781 aagtatcatc ggtgaattaa agaagtatat gtaggaagga aatataaaga catgtttgac 1710841 acattaacac acggagaatt attgaagaaa acggcaatgg aagtggaagc ggacattgcc 1710901 ggcattcata aacaaataga agaaatcagc gagcgaaatg agtggagagt gcttcaaagc 1710961 tatagaaaac acaaagtaag cgacactcat ttcacgccgt ctactggata cggctatgat 1711021 gatatcggaa gagacacgct tgaaagcata tatgcggatg tgtttggcgg agaagcgggg 1711081 cttgtaaggc cgcaaatcat ttcaggcaca catgccatct caattgcttt gttcggtgtc 1711141 ctcagaccgg gggacgagct cctttatatc acgggcaagc cgtatgatac gctagaggaa 1711201 attgtgggcg tcaggggtgg agaaaacgct ggttcgttaa aggattttca aatcggctat 1711261 aatgcggttg atctgacgaa agacggaaag atagactatg atgcagtcgc cgctgcgatc 1711321 aatccgaaga caaaagtaat cggcattcag cgctcaaaag gatatgcgaa tcgcccttct 1711381 ttcttaatta gtgaaataaa agaaatgatc cgttttgtaa aagaaatcaa tgaaaatctg 1711441 atcgtctttg tggacaactg ttacggagaa tttgtggaag agcttgagcc ttgccatgtc 1711501 ggagccgacc tgatggcggg atctctcatt aaaaatcccg gcggcggcct tgcgaaaaca 1711561 ggcggctacc tcgtcggaaa agcgaaatgg attgaagctt gctcataccg tatgacgtca 1711621 cccggcatcg gcagagaagc gggggcatct ctttactcgc tccaagaaat gtaccaaggc 1711681 ttctttttgg cgcctcacgt tgtgtctcaa agtttaaagg gagcggtgtt tacagcgaga 1711741 ttccttgaaa aactcggctt cacttcaaac ccgaaatggg atgcgaaaag aacggattta 1711801 atacaatccg ttgagttttc tgacagagaa aagatgattg ctttttgcca ggctattcaa 1711861 tttgcatcgc caatcaatgc tcatgtgacg ccttatccag cctacatgcc tggatacgag 1711921 gatgatgtca ttatggcagc agggacgttt attcaaggag caagcatcga attatcagct 1711981 gatggcccta tccgcccgcc gtatgtagcg tatgttcagg gaggattaac ctattcgcat 1712041 gtgaagaatg ccatatgcag tgcagtggat tcattgatgc aaaagcaatt aatttaaatt 1712101 ttttaaaaat ttctctggat ttgatgttaa gaatccttac atcgtattga cacataatat 1712161 aacatcacct ataatgaaac taagttaaga aaaggaggaa attgagatga gtgataatat 1712221 tcgccgctca atgcctttat ttccaatagg aattgtcatg cagttaactg agttatcagc 1712281 aagacaaatt cgatattatg aggaaaatgg actgatattt ccagccagaa gtgaaggaaa 1712341 tagacgatta ttttcatttc atgatgtaga taaactgtta gaaatcaagc acctgataga 1712401 acaaggtgta aacatggcag gaattaaaca gattctggcg aaagccgaag ccgagccaga 1712461 acaaaaacaa aacgagaaga cgaaaaaacc aatgaaacat gatctgtccg atgacgaact 1712521 gagacagctc ctgaaaaacg agctcatgca agccggccgt tttcaaagag ggaatacatt 1712581 ccgtcaaggc gacatgtccc gcttctttca ttaatccgtt agcaactgtt ttgctatata 1712641 catttacctt ttaagaggag gaattttacc aaatggcaaa gtacactaga gaagatatcg 1712701 aaaaattagt aaaagaagaa aacgtgaagt atatccgcct tcaatttact gacattcttg 1712761 gaacaatcaa gaatgttgag attcctgtaa gccagcttgg aaaagcgctt gataataaag 1712821 tcatgtttga cggttcttct attgagggat tcgttcgtat cgaagagtca gacatgtacc 1712881 tgtatccaga tctaaataca tttgttatct tcccatggac agctgaaaaa ggtaaagtag 1712941 cacgtttcat ctgtgatatt tacaatccgg atggcacacc ttttgaaggt gacccgcgaa 1713001 acaacttaaa acggattctg aaagaaatgg aagacctcgg cttcagtgat tttaaccttg 1713061 ggcctgagcc tgaattcttc ttattcaaat tggacgaaaa aggcgagccg acgcttgaac 1713121 taaacgacaa aggcggatat ttcgacttag ctccaactga tttaggagaa aactgccgcc 1713181 gcgatatcgt acttgagctt gaagagatgg gctttgaaat cgaagcgtct caccacgaag 1713241 tagcacctgg tcagcacgaa atcgacttta aatatgctgg agcagtccgc tcttgtgatg 1713301 acatccaaac atttaaacta gttgtcaaaa caattgcccg taaacacggc ctgcatgcga 1713361 catttatgcc aaaaccattg ttcggtgtaa acggttcagg tatgcactgc aatctatcac 1713421 tcttcaaaaa tggtgttaac gcattctttg acgaaaacgc agatcttcag ttaagtgaaa 1713481 cagcgaagca cttcattgca ggtatcgtga agcacgcaac aagctttaca gcagtaacaa 1713541 acccgacagt aaactcttac aaacgtcttg ttcctggcta tgaagcacct tgttatgtag 1713601 catggagcgc gcaaaacaga agcccgctta tccgtatccc ggcttctcgc ggcatcagca 1713661 cacgtgttga agtacgcagt gtagacccag ctgcaaaccc ataccttgca cttagcgtat 1713721 tgcttgctgc aggattagac ggaatcaaaa acaaactgga agcgccggct ccaatcgacc 1713781 gcaacatcta tgtgatgagc aaagaagagc gcatggaaaa cggaatcgtt gaccttccag 1713841 caacacttgc ggaagcacta gaagaattca aatcaaacga agtcatggtc aaagcgctgg 1713901 gcgagcacct attcgaacac ttcatcgaag caaaagaaat cgaatgggat atgttccgca 1713961 cgcaagtaca tccttgggaa cgcgaacagt atatgtctca gtattaatat ctcaatccct 1714021 tggcactaaa agtgtcaggg gattttttat gttaataggt aataaattat ggagcggcat 1714081 agtgtttaac acagccatta atcctcagac agtcaaatag ccatttctac tccggttgaa 1714141 agcttctcta tttttgcttc ttatttatct ttcctgtatt gatatatgta tgtagggttg 1714201 gacttataac ataaactatt ctggccattc cgttctttca attcatgacc gggcttgcca 1714261 tcagcataaa tctaggctaa cagtctccat acatcctgtg atcaccttta tcaaactctt 1714321 aaatgcaact taccactaac caattcttta tttcgcatag atcatctttg tcatgtgttt 1714381 acacaagaat ctgttttgga ctgagacact gaatataaca aaacagtcaa aaatcaatat 1714441 ttaattcatt ctgtttaaac tttctgaaaa agatgttgaa aaagtcgaaa ggattttata 1714501 atattaagtc aagttagttt gtttgatcaa caaactaatg aaatgaactt tcattatcca 1714561 caagataaga tcttactaat atggatggaa gggggataag agggtcgatt taatggagct 1714621 aaacaatata agaaacgaaa gaatgaggct tttatccttt tccaggtata taaggtatga 1714681 cgaaaaaaga tgaatttttt gcttgctgat caccatattt ttttgcactg ttttgaaagc 1714741 gcttttataa aagtttactg accgtaaatt cgagaaattg ttataccgtt tcacactgtt 1714801 ccatattaaa ggatcgaaaa ggggagaaat catgctcagt gaaaatgtaa agaagattag 1714861 catggttgaa aaagttggat atgcgtctgg agattttgct tgtaatttaa tttatgcaac 1714921 agtgtctacg tatcttttgt tcttctatac agatgttttt ggtttatcgg cagcagcagc 1714981 cggtactatg tttttagtgg ttagaataat cgacgctctc gctgatcctt ttatcggaac 1715041 aatagttgac agaacgaaca gcagatttgg acgctttaga ccgtatcttt tattcggagc 1715101 ttttccattt gtcatactgg caatactctg ttttacaaca ccagactttt cggatatggg 1715161 gaaattaata tatgcctata taacctatgt tggcttgtcg cttacataca caacgataaa 1715221 cgttccatat ggcgcgttaa cttctgcaat gactagaaat aatcaagaag ttgttagtat 1715281 aacttctgtt cgcatgttat ttgcgaatct tgggggactt gtcgttgcat tttttgttcc 1715341 cttactggct gcttatttaa gcgatacttc cggcaacgag tctcttggct ggcaactaac 1715401 catgggtatt ttgggaatga taggcgggtg ccttttaatc ttttgtttta aaagcacaaa 1715461 agagcgggtc actcttcaaa aatccgaaga gaaaattaaa tttacggata tatttgagca 1715521 gtttcgtgtt aatcgtccac ttgttgtatt aagtattttc tttattatta tttttggagt 1715581 gaattccatc agtaattcgg ttggcattta ctacgtaacg tataacttag aaagagagga 1715641 tttggtgaag tggtacggtt tgataggaag tttacccgct ttggtcattt taccgtttat 1715701 tccaaggctt catcaatttt tggggaaaaa gaaattacta aactatgcat tattactgaa 1715761 tattataggc ctcttagctt tactgtttgt tccgccaagt aatgtttacc tcatacttgt 1715821 ctgtcgatta atcgctgctg ctggaagtct cactgccggg ggatatatgt gggcgcttat 1715881 tcctgaaaca attgaatatg gagagtacag gactgggaaa agaatgggtg ggctcattta 1715941 cgctataatc ggatttttct ttaagtttgg tatggcctta ggaggagttg ttccgggtct 1716001 ggttcttgat aagtttggat atgtagcaaa tcaggcacaa accccggcgg ccttaatggg 1716061 gattttaatt acaacaacca ttattcccgt gttcttgctt gttctagctt taattgatat 1716121 taatttctat aacttagatg agaaaaaata taaaaacatg gttcgagaat tagagaatag 1716181 agacaaagtt tatttggatc atattgatga tttcaaggct taaaaaagaa aataaactga 1716241 ggaggagtcc caaatgaaga ttaccaatcc cgtacttaaa ggattcaatc ccgatccaag 1716301 tatttgtaga gcaggagagg attattatat cgctgtatct acatttgagt ggtttccggg 1716361 agtccagata caccactcaa aagatttagt aaattggcac ttagttgcac atccattaca 1716421 gagagtttca caattagaca tgaaaggaaa cccaaattca ggtggagttt gggcaccatg 1716481 tttaagctat agtgatggga agttttggct gatctatacg gatgttaagg tagtagatgg 1716541 cgcatggaaa gattgtcaca attatttagt tacttgtgaa acgattaatg gtgattggag 1716601 tgagccgatt aaattaaata gctcggggtt tgatgcttct ttgttccatg atacggatgg 1716661 aaaaaagtat ttattaaata tgttatggga tcaccgtatt gatcggcact catttggagg 1716721 aattgttata caggaatatt ctgataaaga gcaaaaatta atcggtaaac caaaagttat 1716781 atttgaagga actgatagaa aactgacaga agctccgcat ctttatcata tcgggaacta 1716841 ttattattta ttaactgcag aaggaggaac acggtacgaa catgctgcta caattgctcg 1716901 ttctgcaaat attgaggggc catatgaagt tcatcccgat aatccaattt taacgtcatg 1716961 gcatgaccca ggaaatccat tgcaaaaatg tggtcatgca tccattgttc aaacacatac 1717021 agatgagtgg tatttagctc atttaacggg acgtcctatt catcctgacg atgattcaat 1717081 ttttcagcag agaggatact gtcctttggg cagagaaaca gctattcaaa aactttactg 1717141 gaaagatgaa tggccctatg tagtaggtgg aaaagaagga agcttggagg tagatgcacc 1717201 ttctataccc gaaacaatat ttgaagcaac gtacccggaa gttgatgaat ttgaggattc 1717261 aacattaaat ataaattttc aaactttaag gattccattc acgaatgaat taggttcatt 1717321 gactcaagcg ccaaatcatt tacgattatt cggtcatgaa tcattgacct cgacatttac 1717381 tcaggcattt gtagccagac gctggcaaag tctccatttt gaagccgaaa ctgctgttga 1717441 gttttatccg gaaaattttc aacaagccgc tgggttggtg aattactaca atacagagaa 1717501 ctggacggct cttcaagtca cgcatgatga agaacttggg cgcattcttg aattaacaat 1717561 atgtgacaac ttttcttttt cacagccatt aaataataaa attgttattc ctcgtgaagt 1717621 aaagtatgta tatttaagag taaatattga aaaggacaaa tattattatt tctattcttt 1717681 taacaaagaa gattggcaca aaattgacat tgcactggaa tcgaaaaaat tatcagatga 1717741 ttatatccgt gggggaggat tcttcacagg ggcctttgta gggatgcaat gccaagatac 1717801 cagtggtaat catattccgg ccgactttag atattttcgt tataaagaaa aataatttgc 1717861 acatgaaaaa ggagatttct attttagaac tcctttttca tatgagaagg tgccatgtca 1717921 ctattgcttc agaaatactc ctagaataaa aaaactcatc tttaaagatg agctgtccat 1717981 tccataaaaa attacattgt aatcatgtcc agaaaatgat caatcacaat ggaggacatt 1718041 cctaatgccg gtgcattctg tcctaaggaa gatggcaata attcatagct attgcctaat 1718101 tgggaataaa cccttgatga tacttcactt ctcattgaat ttaaaaccat aggatgcgat 1718161 tcaattatgc tatttcttaa aattacggct tgtgggttga aagtatttag aatattggta 1718221 aggcctattc ctaaatagaa tccaaaattt tgtaatgcat ttaaggttcc gatatcattc 1718281 agatgggcga ggtttatgat atcttgatag gacagttttt tctctttggt ctgaagagat 1718341 tttaataaag ccttctctga agcatacaat tcccagcatc ctcggtttcc gcaactgcat 1718401 ttaggaccat taaagtctat tgtcatatgt cccatttctc cagagaagcc gcttactcct 1718461 ctatataaat gattgttgat aataacaccg atccctattc ctgtgctgat acttacgtaa 1718521 ataatgttat cgtgattttt tgcagctcca aatacttttt ctccatatgc gccagcattt 1718581 gcctcatttt caataaaaac aggcacattg tacttctctt gtatcgaaga ttttaagtca 1718641 atatctctcc agttggagtt cggagtgaaa acaatttttt gatctttatc aatgagtcca 1718701 ggcacgcaaa tacctatacc aataagcccg tacggagatt ggggcatttg cgtaataaag 1718761 tgatgaatca tatcaatcaa aatgtctttc gttatttctg gagaattgga ttccaaatgg 1718821 cggtattgat caagaacgat tgttccttca aggtctgtta aaatgccatt aatataatcc 1718881 acaccaacat ctattccaac ggagtatcct gcctttttat taaaaacaag catgacaggt 1718941 cttcttccgc cacttgattg tccttgacct atttcaaata ccatactttc tttcattaac 1719001 gtgtttacct gtgatgagac agttgattta tttaatccag tcatttcaga taattttgct 1719061 cttgaaatag gtgaattttt aaggatttct tttaataata acttttgatt tacttttttg 1719121 acaaaggttt gatcagcgat atccacttca tccactccat ttgtttaatc tttaaattaa 1719181 gtatcaacat agtacatagc gaatcttccc tttattatat ctaatgtgtt cataaaaaac 1719241 taaaaaaaat attgaaaata ctgacgaggt tatataagat gaaaataagt tagtttgttt 1719301 aaacaacaaa ctaataggtg atgtacttac tatatgaaat aaaatgcatc tgtatttgaa 1719361 tgaatttatt tttaaggggg aaatcacatg gctcaatctc attccagttc aatcaactat 1719421 tttggaagcg caaacaaagt ggtttacgaa gggaaagatt cgactaatcc tttagcattt 1719481 aaatattata atcctcaaga agtaatcggc ggaaaaacgc tgaaagagca tttgcgattt 1719541 tctattgcct attggcatac atttactgct gatggtacag acgtttttgg agcagctacg 1719601 atgcaaagac catgggatca ctataaaggc atggatctag cgaagatgag agtagaagca 1719661 gcatttgaga tgtttgaaaa actagatgca ccattctttg cttttcatga ccgggatatt 1719721 gcaccagaag gcagtacgct aaaagagaca aaccaaaatt tagatatgat catgggcatg 1719781 attaaagatt acatgagaaa tagcggcgtt aagctattat ggaatacagc aaacatgttt 1719841 acgaatcccc gtttcgtcca tggtgccgcg acttcttgca atgcagatgt gtttgcgtat 1719901 gctgcagcac aagtgaaaaa agggttagaa acagcaaaag agcttggcgc tgagaactat 1719961 gtattttggg gcggccgtga aggatatgaa acattgttaa ataccgattt aaaatttgag 1720021 cttgataatt tggctagatt tatgcatatg gcagtggatt atgcgaagga aatcgggtac 1720081 acagggcagt ttttgattga gccaaaacca aaagagccga ccacccatca atacgataca 1720141 gatgcagcaa caaccattgc ctttttgaag caatatggct tagacaatca ttttaaatta 1720201 aatcttgaag ccaatcatgc cacattagcc gggcatacat tcgaacatga attacgcatg 1720261 gcaagagtac atggtctgct tggctctgtt gacgcaaacc agggtcatcc tcttttaggc 1720321 tgggacacgg atgaatttcc gacggattta tattctacga cattagcaat gtacgaaatc 1720381 ctgcaaaatg gcggccttgg aagcggcgga ttaaactttg acgcgaaggt cagaagatct 1720441 tctttcgagc ctgatgatct aatatatgcc catattgcag ggatggatgc atttgcaaga 1720501 ggattgaaag ttgcccacaa attaatcgaa gatcgtgtgt ttgaagatgt gattcaacat 1720561 cgttaccgca gctttactga agggattggt cttgaaatta tagaaggaag agctaatttc 1720621 cacacacttg agcaatatgc gctaaatcat aaatcaatta aaaacgaatc tggaagacag 1720681 gagaaattaa aagcgatatt gaaccaatac attttagaag tataacagga taagctccag 1720741 atcctgctat caataccaag tcactgaatt acccgtcatg attcctttcc tattgcttgt 1720801 tgttatgacg ggtaacttct ataattagga tttatttaga gtgaatggtt ttttaaaagg 1720861 gcaaggagtg aaaaaatgaa gtatgtcatt ggaatagatc ttggaacgag tgctgttaaa 1720921 accattttag ttaaccaaaa cggcaaggtt tgtgcagaaa cgtccaaaag gtatccgctc 1720981 atccaagaga aggcgggata tagtgagcaa aatcctgaag actgggttca gcaaacaatt 1721041 gaagcattgg ctgaattggt ttctatatcc aatgttcaag ccaaggatat tgacgggata 1721101 agctattcgg gacaaatgca tggattagta ctgcttgacc aagatcgtca ggtgttacgt 1721161 aatgcaattc tttggaatga taccagaaca acgcctcaat gtataaggat gaccgagaaa 1721221 tttggcgatc atcttcttga catcacaaaa aaccgtgttt tagaagggtt tacattacct 1721281 aaaatgttat gggtaaagga acatgaacct gaacttttta aaaaaactgc tgtgtttttg 1721341 cttccgaaag actacgtgcg attccgtatg accggtgtca ttcacaccga atactccgat 1721401 gcagcaggaa ctttactttt acatattact cgcaaggagt ggagcaatga tatttgcaat 1721461 caaattggta tttctgcaga tatttgtcct ccgcttgttg aatctcatga ttgtgtagga 1721521 tcgctgcttc cgcacgttgc cgcgaagacc gggctattag aaaaaacaaa agtgtacgct 1721581 gggggagcag ataatgcttg cggcgctatt ggagcaggta tcctttcttc cggaaaaaca 1721641 ttatgcagta ttgggacgtc aggggtcata ctttcctacg aagaagaaaa agaaagagac 1721701 tttaaaggga aagtccactt ttttaatcat ggaaaaaagg attcttttta tacgatgggc 1721761 gtcacgctcg ctgcaggata cagcttggac tggtttaaaa gaacgtttgc accaaacgaa 1721821 tcgtttgagc aattattgca gggggtggaa gctattccga taggagccaa tggactgcta 1721881 tacactcctt atttggttgg tgaaagaacg ccgcatgctg attcttctat tcggggaagc 1721941 ttgatcggaa tggatggagc ccataataga aagcattttt tgagggcaat aatggaaggt 1722001 atcacattct ctttacatga atcaattgag ctattccgcg aagcgggaaa atcagttcat 1722061 actgttgttt ctattggtgg gggagctaaa aatgatacgt ggctgcaaat gcaagctgat 1722121 attttcaata cgagggtaat taagttagaa aatgaacaag ggccagctat gggggctgca 1722181 atgctggctg cctttggaag cggttggttt gaatcacttg aagaatgtgc agagcagttc 1722241 attcgtgagg ctgctgcatt ttatccaaag gcgcaaaatg ttcaaaaata taaaacacta 1722301 tttgatttgt ataagaacat ttacactcac acaaaggatc tcaatacagc tttgaagagc 1722361 tttcgaaaaa actaatgatg ttattgtctg gagatcaacc gaagaacaat taatgatcaa 1722421 tcatcatcaa aggcctttga taacatggct gccttctttt gaaaagatgg tgagaataag 1722481 gtatcgcaac ctttaaacag tattggagta tccagcagac aaaacgaacg agtggaaccg 1722541 tattttgtca gcgaacactt caagaagtgg ggaagcttag gaatgccaat gggtaagatg 1722601 tatgaaaccg cgctaacgac ggtagaggga tctcttgatt tatgaagaaa taggaaggat 1722661 gttaacacac aaataacccc tcacattgac gtgaaggggt gttttttatt gttactatac 1722721 agcggaaatt ttacaggcta gttgcatgat tttagcttgt taagcagaat ggaactagac 1722781 tctccatcat ctctttctca ttctttggaa actgcattct gctaggtttg ctgctttttt 1722841 taacaaacag tgtttttcta tttcacacag ccattaaatc ctctgttcgt cacataaccg 1722901 ctcttactcc aaattgacag tttatctgat tttgcttctt gctcatctag tctgaattgg 1722961 tctatgtatt ttgtgttagg ctcatataca tatgctactc tggccaatcc ctctttcaat 1723021 aatgtctctt gaacagattt gccgtcaaca taaacgtatg ctaacagtct tccatactta 1723081 tctctgcgat cgcctttatc aaattccagc tgtagcttac cgctgttgac caattcttta 1723141 tttcgtttcg acgcatcctc accgtatggt tgaacacaag aatttggttt cttcgtctca 1723201 ggtgtatcaa cgagcaagta gcgaactgtg tctttctttc cgttgtaaat aaccttaatc 1723261 gtatctccat ctattgctct atctaatgta acattgacca atttcttctg attttttgaa 1723321 tgaggcgtgc cagccttttg ttctgtctga ttatattcat tagagtgagt atcttgagag 1723381 acttgctccg tcccattaga atctgaatgg tttttggctg cgtgatttga tccgcaagct 1723441 gccaaagtaa tacttaaaac gattgcgatc atactgatca aaatcttctt catattgatt 1723501 ccctctttat cattttctct tttcgcgatt aaacatcatc attataacga tatggacatt 1723561 ttttgtgaat ggaaaacttc aagggaactt ataacactcc aaattgccaa tagttaactt 1723621 cacaacgaga tgatcaaaac atcaccatca catagcggaa ataaataatc ctgaaaataa 1723681 tattgactga aaatgctttt agaattatga taatatgaga aatgacaata atgtgacaaa 1723741 gacattacta caacataaca actaatagct taggtttatt ctattggtta aaaatgtaaa 1723801 cggttacaaa tccagaggcg aaaatctaag atagagatga ctttagtttt gactcaatat 1723861 ccacactgaa agagcttatt aagtattctt aaaggcaggg gaaatggata tgaatgaaca 1723921 tcgaaatcga aggttgaaat taataatgat ttcagcaact tttggagggc ttctctttgg 1723981 atatgacacc ggagttataa atggagcttt accttttatg gcaaggccag atcagcttga 1724041 tttaacacct gttacagaag ggcttgttac gagtattctt ttattaggtg ccgcgtttgg 1724101 agcgttgtta tgcggaagat tggctgatcg atatggccgc cgtaaaatga tccttaatct 1724161 ttccttttta tttttcctgg catcactggg aacagcgtta gcacctaatg ttttcatcat 1724221 ggcggtcttt cgttttttac tggggctggc tgttggagga gcctcggcga tggtgccggc 1724281 ctttttagca gaaatggcac cgcatgaaaa gagagggcgt atggtaaccc aaaatgaact 1724341 aatgattgtt ggcgggcaat ttttagcata tgtttttaat gcgatcctcg gtgtaacaat 1724401 ggcaaatacg ggacatgttt ggagatacat gctagtcatt tgtgctgtac cggctatcat 1724461 gttatttgcc agtatgctta aggtaccaga aagcccccga tggctaatct ccaaaggcaa 1724521 aaacagtgag gcgctgcgag ttcttaaaca aattcgagaa gataaacgtg cagaagctga 1724581 atgtagagaa attcaagaag cggtagaaaa agatacagca ctagaaaagg catcactcaa 1724641 ggacttttct acaccatggc tgcgccgtct tttatggatt ggaatcggtg ttgccatcgt 1724701 gaatcaaatt acaggtgtga actcgattat gtattatggc acacaaatcc ttaaagaatc 1724761 tggttttggt acaaaagcgg ctttaatcgc taatattgga aatgggctga tatcagttat 1724821 tgcagttata tttgggattt ggctggtcgg aaaagtgaga cggcgtccaa tattattgat 1724881 tggtttggca gggacgacta cagcgctcct attgattgcg attttctcaa ttgtgcttga 1724941 tggatctatg gcacttcctt atgtagtgct ttctttgacc gttttatttc ttgcctttat 1725001 gcaagggtgt gtaggacctg tgacttggct tgtcatagcg gaaatattcc ctcaaaggtt 1725061 aagaggactt ggttctggga taagtgtttt tttcctttgg atattaaact ttgtgatcgg 1725121 ttttgctttc ccgatcttgc ttagctctgt aggtttgtct tttacattct ttatatttgt 1725181 ggctttaggt gtattggcaa tcggttttgt gtacaaattc atgccggaaa caaaagggcg 1725241 tacacttgaa gaattagaag agcattttcg ttctcgacac gatcataata ctcctgaaca 1725301 atcagttatt gaggtataaa tatgttgaaa atctctcttc ttataggagg gattttttta 1725361 gtttcagaaa aaacaaaatc cctctggtag agggattttg attcagcatt ttaagatgtt 1725421 ctacacgtat aatactggag ttgatacttt aaaaatctcg ccatctctta tataaaaacg 1725481 agggatgcgg cggcttaatg tagacacgac ttcatagtta atcgtattga gcatttcagc 1725541 cacttcatca acggaaatct cggctccttt ttgcttaccg taaatcacga cttcatctcc 1725601 ttgtttacct tcaccgtttt ctcctaaact gaccatgatc atatccattg ttactcttcc 1725661 cgccactggc actcgttttc cgcgatgaag aacaaacccg cgattggaaa gggcacgaga 1725721 atagccgtca gcatagccaa tcgggagtgt agcaattact tcattaggtt ctgcgatgta 1725781 tgtagcacca tagctaacgg ttcggggttc tgtccgcatg gttttcacat aagcgatgcg 1725841 tgcctttaaa cttaacgcag gttcaagctt aacgagattt agttgtttaa tataggctga 1725901 aggatataaa ccatataagc cgatacctaa acggatcata tcagcgctaa attccggaaa 1725961 tgcgatagct gcagccgtgt tgcacatatg cacggtgggc agctcaatcc cctgtttttt 1726021 taaaaagctg agaaaactga tgaatttttc atgctgcagc tttgtgagtg ttgtgtccgg 1726081 ttcatcagct gtcgaaaaat gtgtgaaaat ccctgtccat ctgaggaatt tacttgcctt 1726141 taaggctttc actacctcta aaagttcttc ctttgtgcgt acacctaatc gtcccatgcc 1726201 ggtatccacg ttaatatgaa tggccagccg gttagcactc gcttcttttt ccaatatctc 1726261 gtttgcttct ttcatccaat caacctgaaa tgctgataat gttatattcc aagctgctga 1726321 cttctttaca caactaaggg atgtaaaacc aagcacaagg ataggtgctg taatcccagc 1726381 tttacgtaaa acgattcctt cctccacact ggcaacagcg agctcactcg ccccgtgttc 1726441 cagtgcatgg cgtgccactt ctatagaccc gtggccataa ccgttcgctt ttacaacagc 1726501 cataattttg ctcttatgtg gaatatgacg gcggatcgct cgcaaattct ttttaacggc 1726561 atcaagattg acttcgatcc aaacttctcg gcaaagcttt atcatcaacg cttccttcct 1726621 tcttatggat tataaatacc acctattgcc gcaagaataa atgttaattg ttggatgatt 1726681 cgatcttatt ttattcaact ttatttgaaa tcattcaaca gcaaatccat gtgatacgag 1726741 aaggtgccta tcaatgttcg aataatagca agtacgggat acatgaggct tgtaagtggg 1726801 gtgttaatgg atgcggcgac cgaggattac aaaaatgatt atttgttttg ggacattttt 1726861 ttctaagggt agatgataac gagaaatcta atcaggaaat acttaccgtt gttatgaaca 1726921 ttgaagaacc ttttaaatga gaagggctga ggaaattctg taaaagataa tcggttgaaa 1726981 aggcagtcga ttccttgttc cataaaccta acatcagagt atataattat actcgtattc 1727041 acaaaaatcg tttaagtaag gggtatacat gaatagggga gttagttttc aaataccgaa 1727101 tgaatatgga aattttctat ggagaatact gcagccggta gaaatagcta attataggtg 1727161 gcaaacgagt ggggaatctt attttgttgt agaaggagag ctcgatgatg aggagctttt 1727221 tcatgactac gaaattgttg agggggcagt ttttgagcaa caattaaaaa cgaatcagta 1727281 ctataccatt ttcgttgaac tgaaagcatt tccatatgga aaaatggtta atcaagtcaa 1727341 tacatatgaa gagtttgctg acagtgattg cgaacttgtc cttttgatag cagataatag 1727401 ctacgtttcg atttactgta aaaacaaaaa tatcattgaa aaactttact tcaatgcttt 1727461 acagcatgat tttgaagacg ttcaatttat aactgatgaa aatgacacaa gaacaagcct 1727521 tactgtatga tactcaataa aaattaaagg agctagtaca tgacaatgca aattaaaatc 1727581 aagtatctag atgaaacaca aacaagaatc agcaaaattg agcagggaga ctggattgat 1727641 cttcgggcag ctgaagatgt aacaatcaaa aaagatgaat ttaagcttgt cccattaggt 1727701 gttgcaatgg agctgcctga aggttacgaa gcacatgtcg tccctcgttc aagtacatat 1727761 aagaactttg gcgttattca aacaaattca atgggtgtta tcgatgagtc atataaggga 1727821 gacaacgatt tctggttctt tcctgcttat gcattgcgtg atactgaaat taagaagggt 1727881 gatcgtatct gccagtttag aatcatgaag aaaatgccgg cggttgaatt ggttgaagtc 1727941 gagcatttgg gaaacgagga tagaggagga ctcggttcaa caggtacgaa gtaaacaaaa 1728001 taaatccttg gctgtcttca tgctgtgtga ttgatcaatg gaggtttcag ccaaggtaca 1728061 tataaatatt atgtataaaa tgaatatttt aatacgaagg atttaattaa aaacaaagtt 1728121 taaaaaggga agttttgaaa aagtgaaata gtaataacta aagtcgataa agaacctaaa 1728181 gatgtcaaag aaacaatttt tctggtgctt tgcttttttg aaggtttact tagctcgtgg 1728241 ataactgccc cccataaaag catggatgct aaaattataa tacttatata cataaagatg 1728301 ctccttttat tatatttaca gtttttacat ttttatcgat tttaccacat ttaggattga 1728361 gttgtcgatg aaacaagcat ctctataaag aaatactttt atctaaattt ttataaatag 1728421 gggaaggcaa ctaaaaacta gtaatgccac taataataag ccaagttaaa tgacttgtgt 1728481 tcattaataa ttgaatttta cagcagccat gagcacaaaa aaatctgagt tcgtcgataa 1728541 atatcataaa aaagcccccg gtatgtcgcc agggaataaa tagacgttta agagatttag 1728601 tgatgttttt tatatgattc gacaaaatca taataatgat catcgtcatc ataatacttt 1728661 ttttcgtaat gataatcgtg atcatcgtaa tactttttat catggtcatc atactttttg 1728721 tcgtaatcat aatgtttttt atcatgatca taatacttgt cgcaatcata atgcttctta 1728781 tcattgtcgt aatacttttt gtaatatgtt tttttccaag tataatactc ttctttatat 1728841 tttttataat aacccaatta aattcctcct ttatgttatt cgaatttaat ttatgaagtt 1728901 taaatgatat ggtatggtca aatgaaataa gaatagtaaa aagaggctgt ttaaaacact 1728961 ttctgaaaaa caaaacggat agctgtttat gaaaataaga gcgagagaga gcactcaatc 1729021 actgtaaaat aatagtaaag tgtatagaga gattagtata cgtaaaaagg gactttctca 1729081 ttgaagaata tttgaacgtt atggttaaga ttcaagagct ctatgatgtg atttttcaca 1729141 ctgcttttga aggatttaga gttagacatc aaaaacaaac agcaaaaccg gctagaaaca 1729201 gatcatataa ggaatgaacc gctgccaaat atcataaaaa agttgttaat gatcaaatga 1729261 atgaaattag agagaattta ttttaaagaa agcccaattg cacatggaca aatgacaatt 1729321 gatattgagg taaaatacaa tgcattaaat cagaaaaagc tattggagga tttaatgtgt 1729381 ttagacaatt tccaatttgg tatacacaaa cacctgacta tttgaatttt tatgtaccgc 1729441 aatatcaaac catttcgtat aatcctcaac aatgttatca acggtgtatg taccaaactg 1729501 gcggtaacta tgagctatgt gacagactat gttatggaga aatacaggtg taaaagaggg 1729561 ggattaactc ctctttaaac acacagtgag tggaataaga tcctcacttt atctgcaagt 1729621 gcttagtatt tgcgataata ttgcattcgt aataaattat gcttagcaac tgaaaatgaa 1729681 agaaggatat gaatagtcat gacgcaattc gataaacaat acaattcaat tataaaggat 1729741 attatcaata atggaatctc agacgaagag tttgatgtaa gaaccaagtg ggactcagat 1729801 ggaacaccgg cacatactct aagtgtaatc agtaagcaaa tgagattcga caactcagag 1729861 gttccgattt taacgacaaa aaaggttgcc tggaaaacag ccattaaaga gttgctctgg 1729921 atttggcagc tgaaatctaa tgatgttaat gatttaaaca tgatgggcgt ccatatttgg 1729981 gatcagtgga aacaagaaga cggaaccatc ggacatgcat atggatttca gctggggaag 1730041 aaaaacagaa gtctaaatgg agaaaaagtg gatcaggtag actatcttct tcatcaattg 1730101 aagaacaatc catcttcacg cagacacatt acaatgctgt ggaatcctga tgaattagac 1730161 gcaatggcct taacgccatg tgtatacgag acacaatggt acgttaaaca tgggaaactc 1730221 caccttgagg taagagcacg gagcaatgat atggcattgg gaaatccatt caatgtattc 1730281 cagtataatg tgttgcagcg catgattgct caagtgactg gttatgagct tggtgaatat 1730341 atctttaaca ttggggattg ccatgtgtac acacgtcata tagacaattt gaaaattcaa 1730401 atggaaagag aacagtttga agcacctgaa ctatggatca atcctgaagt gaaagatttt 1730461 tatgacttta ccattgatga tttcaagtta atcaactata aacatgggga caagctttta 1730521 tttgaggtag cggtttaatg ctgccttttt attgtgcagt gaatagatag caggtatcct 1730581 aatttcatta agcaatctgg aagatgaata aaaattgaag gacaaacacg tataatacat 1730641 aaaaaagatt aactctacag ttaatctttt ttattcagaa gaaaatatcc taactttgaa 1730701 actaaataca aagtaaaagc aatcattaca gttctagata ttacaattcc atgaatagct 1730761 agatcatatc cagcaggtat caacgcattt gtattacaca taaaatatat agatattaga 1730821 agtgctacaa taactaaaat cattccaaaa agacttgttt tttcatattt cataccaatt 1730881 tccaccctta ttaaagttag gtttaaacaa aagagctgaa gaaacgaact atgaccagta 1730941 tgctccaagg aaaaccgcca gacaatgctg gcggcttttt gctgcttcgt ttatttatta 1731001 acagagatcg taacgttatt tcctgcaact gaaacctttg cgaaatcctg tgtatctacc 1731061 acaggagtga cggctttatt gtcgatagtg atgttgttaa aagaggtcga aaaggttgct 1731121 ttgatcgcat cacgctggct ttcatacgaa acagccgcgg tagcaagtgt tttccatttt 1731181 gaaatcgtgc cgatgttggt tccttgaatt tctgtgataa tccgtccggt gtagccgtca 1731241 ttgttcgttc cccaaagggt catgcgcgta ttgccgctta aatttttata gattgtcatt 1731301 tggactgtgc ttccagggcg gaagccttta ttgtatgtga atttgtcttt tccttcgatg 1731361 tacgtttctt catttttgga cccaaccttc atgaggggct tccagacgtt gtattgtttg 1731421 ctgtactgaa gcccgatatc ggcttcagtt ccgcttgttg ccctaaagcc agaataaata 1731481 tagggagtag agaccgagtc gttgtttttg acagtttcag gaagcacgat tttagctgta 1731541 aaaacggcgc ccgtactgtt caggtagaca cggccgccga ttccgttagg cagctcggat 1731601 gctgcttttg cgacttgagc gtctgccgcg ggtaaacctg gtatacctga tgaaagggtt 1731661 ccgaaaagaa ctgctgttcc tactgcacct gcaatcaata cttttttcac caaaattccc 1731721 ccttttgata gtggtttcgc catttattat accttatttt ggaactggat ttacgtatat 1731781 aaatcgacaa aatatttcat tttgaatgat gtaaggtcga aacgcttcgc caatctgaaa 1731841 gctatatacc tttatcagag gaaagaatga gatcacattc gttttaaccg atttgaaatt 1731901 ttcctcaaaa taaaagtaca aatgcttaaa gaaacgatta ttaaaagaat gcccgctatc 1731961 gtttccaagc ctgtaaaaaa gaggtgacgt ttcatcaatg tctgtccttg taaaatgata 1732021 aaagcacaga taccgactaa gaaaagaaaa caaatactta ggattgctaa cgctttacgt 1732081 gagtatgttt tcatttcatc tttaaaatac agcaatacga aaataaagca gataacattg 1732141 gctattgttc taatcacctc aaagcttttc atgacaactg atataaatag acaaagtaaa 1732201 atgagataaa atacgatgtt tctatacaaa aaacctctcc ttttatgtag gatcctcaaa 1732261 gagtttataa aagtttcttt gtaactgcaa taaattgaat gcgctcactt atgaactaac 1732321 taaactatgt actaaatatt cactattctt tttcagattc agtcaccaag gttttcatag 1732381 aaagggaagc ttcagaaata tacatatagt gcacaaacaa aaaagacccg gcaatagccg 1732441 ggggaaagta aaaacgagga gatgttaatg gcgtttagta gtgtttttta tgctttttat 1732501 actctacaac ataatcatag tcttttttat cgtgatcata atatttttta tcatagtcat 1732561 catatttttt gtcgtaatca cagtcataat cttttttatc atattcgtaa tacttcttat 1732621 aatacgtttt tttgaccgta taatactctt ctttgtattt tttgtaataa cccatatata 1732681 ctcctccttt atttttacta cgctttatta tacggcgagt agattttgcg gcttggacag 1732741 ttaaaatcat agaaggaaaa aagggctgtc caaatgatag aaaaagacag atgacacaaa 1732801 aacaaatcaa aataaagagc cgatttttca tcggcccaaa cgatttatcc tacatttgtt 1732861 tgtcttcttt gttttctgag tcattttttc tgatatcctg agtcagtccg cttgttgctt 1732921 gtttaaattc tgataaggct tttcctgctg cacggccaag cgccggcagt ttatcaggcc 1732981 caaatactaa aaaacccaca aacaaaataa cgagtatttt tgtgaagctt aattccatat 1733041 ccttttcccc ctgattgaag tacaaccttt taaacaaatt ataagagata gcagtacaaa 1733101 tgggaatgca tttattttga acattttaaa accagcacaa agacggattc ataaaacggc 1733161 tgctgctgaa tataatgtcc aatgccacct gcctaagaag caggaggcag gctggatcaa 1733221 ttatgtagct ctgccggaaa tgatacaaac gtagcggcta tcattgacat agaggagtgg 1733281 tgtagctgat gagattcact aaggtagttg gatttttgtc tgttttaggg ttggctgcgg 1733341 tttttccatt aacggcacaa gcagaaaaag ccggaactgc gggggctgga gagtgggata 1733401 agttggggac ttacacatat acttactcaa gtccgacggt atactcgacc ggaggagatt 1733461 ttagagtgtg cctttcagga agcactcctt tttctgtttc actgcactta tatgaggatg 1733521 atcccggtga caatcctgat gattatgtag gggcaaacta tttttcaccc ggagaatgcc 1733581 acacctttgg cagtattgga aaatttgtag atgggagcaa taacaaggcc gagttctttg 1733641 ttaccgatta ctctggtaaa tctaaaactg ttacgtttta tgattgatgg actcaaattg 1733701 tgaagtataa cccttggaaa aaaacaaaaa agagagatac ctctctcttt tttattcttc 1733761 gacagcctta cgaagccgtt catttacaat gccagtccag ccgccatcca tcttaccgcg 1733821 aacgacggag cttttctcgt ttgctttgcc gatcacttca ttcggctctt tccagccgct 1733881 gtgaataagg gtaaaccctg tcttttcccc caagtcttct aattgaaagg taacgaccca 1733941 tccttctgta tcccattcaa aagaaagttc agttggagct tgaacagcca aaactttaca 1734001 aggggacggc ccaaacggcg attgtaagtg aaattcttgt ccttctttga gctgaaagtc 1734061 attgggcata aaccacttgg caatgccttc tgaagtagag actgtctccc agactttctg 1734121 aatgggagcc tccagagtaa tgctttttgt aatatccggt aatgcatttt cgttgttttg 1734181 agccatttcg tttacctctt gacatatgat gttttttcaa ttcaatcata taataactaa 1734241 taagatcatg tccatagcgt gcattattta tgctagagct gctgttgaac agcgtgtcag 1734301 tcgccagtct gatctgtgaa tgggagaatt ctgcatgcgc gaaaaagaga gagaggtgta 1734361 tgttgtcatt tcgttcattc ttgtttgcag ccgcaactgt tatgtttgaa ctgggattcc 1734421 tgttcagcca atttattttg cgatttttgt tttaatagta aatgagccat tttctaaaac 1734481 aggaggtttt ttatgcttgg aaaaatcaaa gcagccattg ataatagtcc agggaagccg 1734541 gccagaattt tagttagtga aaaagcgttt cagcaattag aggaagaaat gcgctttgtt 1734601 tacgtttcca aaccgaaaac gataatgggg attcctgtgg aagtttcaga tcaggcagaa 1734661 agcttcaagc tggaatttta gttttcccag actgctaaaa ggctcatttt gtgttaatta 1734721 tgcaaaatgg tcaggttgat ttctttaaaa gcatgatgaa atgttcatca tgctttttta 1734781 ttgagaaaaa agacgaacat aaaaaatagg tatacgggaa aaataatcct attagagaga 1734841 ggggaactga cagatggata acatgatatc aacacttact gactggaatg tgtggtttca 1734901 agcgttagta gtatttctcg ttccatatgt aatctataaa gtgtttactt ggattcatgt 1734961 ataagaaggt gcaatgatga ggtggcggaa caatcagtac aaaacacaga agcagcataa 1735021 atcagattat tcgacagctg aaaagcagga tcaggatgtg ttaaccggta acatcggata 1735081 cgacttagaa catgtaaaaa gaaaaatagg acataacggg gacgttcatt tccgtgagct 1735141 tgaaatcact caattacatg tgaaagcggc attgatcttt gttgaaggac tgtctgatca 1735201 ggacttgatt aataaaggac tatcagtgtt agtcatgaat caacctaatc aggtaagcga 1735261 tgaaatttct caatccggca aaggtatttt aacttcgaaa cagataaaaa atcaaatcgt 1735321 atcaatcggt gatgtcatag attcagagaa aatcagtgat atcgtgttga atgttttcat 1735381 gggttcgaca gcgcttctca tcgatggaat accgcaggcc tttcttctgg gaactgtaaa 1735441 aaaacaaaat cgaagtatcg aggagccgct ttcagaagcg cttgtcagag ggccgcgcac 1735501 aggctttaca gaagagttga gtacgaatac agctcttttg agacagcaag gaaaaaatga 1735561 tcaattaaca ttgcagagat ttgaagtagg aacacgatta aaaaaggatt taattatcgc 1735621 ttatatgaat gacattgcag atccaaaagt agtcgaggaa gtaagaaaaa gagtgagagg 1735681 gattgagatc gatcatttgc cggagtcagg ctacgttgaa cagttaattg aggataatta 1735741 tttgagcccg ttcccgcaag tacagagtac agaacgtcct gatcgcgtca taagcggatt 1735801 aatggaagga agagtagcta ttctgcttga cggcactccg tttgctttga ttgttccagt 1735861 cactttcagc atgatgcttc aatcgcctga agattattat gaacggtggt tcccgagctc 1735921 gctcatcaga ttgctgaggt tcatcgcagc aatgataacg ttattcgcac ccgctttata 1735981 tatatcattt atttcttttc atcctgggtt aattccgacc aagctggcga tttcaatttc 1736041 cgggacgcgc caaggtgttc cgttcccatc tctgattgaa gccttattta tggaagtcgc 1736101 gattgaaatt ttaagagagg cggggcttcg tttgccaaaa ccaattggac ccgcaatagg 1736161 catagttggc ggattaatca tcggggaagc agctgtgcag gcggggattg tcagtccaat 1736221 catggtcatt gttgttgcgc tcacagcaat ttcttcattt gccatcccgc attatagcac 1736281 aggtatagca cttcggatgc ttcggtttgg cgcgatgttt tgtgcggcgg tgtttggatt 1736341 gtttggagtc attatgtatt atctgctgct aagcagccat gtcgtaaagc taaagagctt 1736401 tggtgtgcca tacgcaagtc cggcagtgcc ctatcactta aaagattgga aagactttgt 1736461 tatcagaatg cctcttttag tcatgaagcg ccggcctaaa atgatgaata cagataatac 1736521 aaaacgggtg aagtgatgaa ctcgacagga tggtgataaa gtctcatgtt cagcccaacc 1736581 agtaaaatca caaccgctca ggcaacgatt atcatcatta attatatgct tgctgccgga 1736641 gttcttacgc tccctcggac agtaacagaa caaacacaat ctcctgatgg atggatttca 1736701 gttttattag gcggggtcct agcggtaata gccgggatga ttatagctaa attaagccag 1736761 cagtatccta aggagacctt ttatgaatac tcccgacata ttgtaggaaa atggctcggg 1736821 catctgatca gtattgtttt tattacttat tttctggcac tcggtgcatt tgaagtcaga 1736881 gtcatgtccg aaatcgtgga tttttttctc ctcgaaggga caccttcttg ggccatcatt 1736941 atgacagttc tttggattgg gctttattca attacacaag gcctagatcc gattgcacgg 1737001 ctttttgaaa tgatttttcc gattacggtc atcatctttt taacgatagc cctcatgagt 1737061 ttaggcatat ttgagatcaa caatttgcgc cctgtattag gtgatggaat catgccggtt 1737121 cttagaggtg taaagacaac gaacctttca tttacatgtt cagaaattat gttcatttta 1737181 gtagcattta tgaaaaagcc gaaaaatgcg gtgaaagcag ttgtgatcgg gacaggcgtt 1737241 gtgaccagtt tttatatgat tacgatgatt atggtcatcg gtgcactatc agttgaggga 1737301 gttgtgacga gaacatggcc ggggcttgac ctgatgagaa gttttgaaat acctggttta 1737361 atatttgaac ggtttgaatc atttctgctt gtgatttgga ttatgcagct ttttgccacg 1737421 tttattatca ctttttatgc agcttccctg ggagtctcac aagtttttaa aaagaaaccc 1737481 ctttcatgta tgtttgggct gcttcctgtt atatatatcc tctcttgcat gccgaaaaat 1737541 gaaaatgacg tctttatatt gggcgatacg gtcagtcata tcgctttgta tatatttggc 1737601 gctttgccga ttttgctgtt agtcatttcg aaatggagga aaagaggtga aaagtaaact 1737661 aaaacgtcaa ttgcctgcta tggtcatagt atgtctgctg atgatttgcg taacaggatg 1737721 ctggagcagt cgggaaatag aagatctggg tctcacattc gctatcgcaa ttgataaagg 1737781 aaaagaaacg aacactgaaa aagagttaaa agaagagggc gggagctatc cgaaaaaaga 1737841 caacattacg ctgacctatc aatttgttaa tgaaaaagcg gcaggcgcgg gcacaagcgg 1737901 gggaggcggt agcggacaag gagcgcaaaa agcgtacatt aatataagtg aaacagggga 1737961 ttcattacag cagatcggaa gtgaggttgc attaagacgg gaccgagaag tgtttagccc 1738021 gcatttaaaa gttgttgtca tgagtgaaga tgtgctgcac acatttccta tcgacgaaat 1738081 gctggatcaa ttttttcgtg ataatgaaat caggctgagc tgtcttgttt tatctgctaa 1738141 aggggaagca agagacgctc tccagctgaa agagaacgga gaaattccgg catttcggct 1738201 gattggatta ggtgaaaatg aacataaagt ttccagaatt cttcccccta tgacactcgc 1738261 gaaactaatt ggaaaactgc attctggcag cagcttttta ctgcaaaatg tggttgcggc 1738321 gaatggagcg gtcaagtatt ccggagcagc tgtaatcaac ggaaaatcga aaaaaatgat 1738381 aggcacctta aatgaatatg aaactgaggg gattacatgg attagaggag aagggaaagg 1738441 cggagttgtc aaaagtcatg ataaaaagag ccaacagacg ttagcgtacg atatcaataa 1738501 aatcaaaagc agaattcagc caatcgtaaa agggaaagat atttcattcc atgtcgatat 1738561 tgaatcagaa ggcgatttgg ttgaaaactg gaacacaaaa gaggcgttgg acacccagtt 1738621 tatagatcgt ctcgaaacga ctattgaaaa cgaggtaaag aaaatagttg gtcaggtatt 1738681 aaaaaaaatt cagcatgatt ataaagcaga tgttgcgggt tttgatgaat cttttagact 1738741 tacatatcct cacttatgga aaagggtgaa aaataactgg gatgacacct tcagtaaagc 1738801 cgacatcaca tacagtgtga acgtcacaat tactcatttc ggcacggtta aaactcagta 1738861 atgaatccca aggaagagaa ggaaacctct cttctctttt ttatgcattt attaggataa 1738921 agatactttt tttggagaga tatacacttt tcaaatcgac caatatgcta atataggaat 1738981 tgcttgaaat agaagggaga aggggctgtg aggcagaaac cgatttatgt agaaatcgaa 1739041 atgaaatctg atctggatac actctgggaa tatacacaaa acccatcact gcataaggaa 1739101 tgggatctcc ggttttcaaa tattacgtat ttgaatagtc agccatgcga aaaacagaag 1739161 tttctttacg aaacaagggt aggctttgga ttaaaggtgt caggtacagg agaaaccgtc 1739221 ggtgttttca acaaatgttc atctgaaagg tcttcttcac tggcttttgg ctctgatcat 1739281 ccattatctc tgattcggca tggaagcggc tactggaagt atatacagag agaaaatggg 1739341 aaaatgacgt ttttaacaca gtaccaatac aaaacagcct acggactgct gggaagatgg 1739401 attgatcgtt tattatttcg gccgctgctt ggctgggcga ctgcctggag ctttgatgca 1739461 ttaaggcttt gggtagagca aaataaacat ccgaagcgct tcattcgatc tgctatcatc 1739521 tatgtgttca tgtgtctgtt tttcagcctg ttttggttct atcaaggctt tgcaggtgtt 1739581 aagacaagca tattgacagg aacagcggag ataggcttag ctattttgtg gctgcttcct 1739641 ttaaaaagaa aatggatcat tcatggtgtc caggcttgta tttttgctgg gtttgcttgt 1739701 ctaggttccg aaatattcat gtgggttcta ttgagtgtgt tttccgctgc aagcggcgct 1739761 cttagcctgc agctccccag tgccaggcgc acaaaacgaa agagaaagaa gtgacattgt 1739821 gagttcgatt tatgaaaaat caattattaa ctatcatttg ctgcatccca agctgcagaa 1739881 acggtaccaa ttagacgggt ctcatacatt cagcgggacg ggaacgatgt cagaaataag 1739941 cggaggctct tttctggtta gaatgctgtt aaagctgggt gtttttttca gatgcttctt 1740001 ttcagaaaga ggcaaagaca ttccatttac aatacaaaat agaacttgtc ttttgaaatc 1740061 gcaacataca ggaatagaat ggaatcgtac atttttcttt aaaggcaaaa aacgtttctt 1740121 tgatgcgtta atgatatatg acgagaaaga aaatagaata cttgatttct tcggcaaacc 1740181 tcatctgctg ctgtctgttt tgacgttcga ggcatctctt gacggctctc ttacgatcac 1740241 atcgggaaag caatggctat tgatatgcgg aaaaagaatc ccgctgccga aatggctgac 1740301 cggtacatcc gaagtttgcg aaacgtttga tgaaaaaaag aattgtttca ccattgaagt 1740361 gcatgtgcaa aatacaattc ttggcactct tttcttttat aagggaacgt ttcaggagga 1740421 agagagagaa tcatgaaacg aaatggcata gtcagtgcgc tttgttttat tggatttctt 1740481 gcagcagaag caccggatat ttcagtggca gaggcactcg ttttgttatc cattctattt 1740541 ttcgtgccgg gaatttttcc ttttgttttt cgtcaatctc cggttcgtgc tgctcagttt 1740601 atggaaaacg ggctaatcca gtgctatcct gtagccgcat tctttgcggt gctggctcta 1740661 gtgacggagg ttgggggttt cgcacttatc tggtggatgt acacagtttt taatgcattg 1740721 tatgcgatcc tccgcctttg ggaaacaaag atacatagaa tcgaagagac atcagttttg 1740781 ttcggtctta tttatttggc gggaggagga ttttggtttt ttgcttatgc tgcccatttg 1740841 cagatcatgc aatttggccc tctcatcatt ttgctgactg ctgtccactt tcactattct 1740901 gcttttctga tcccgatctt caacggttta ctcggcagaa ccattagaaa acatcggatg 1740961 ttgtacagtt ggataacatg ggtgattttg ctttcgcccc ttcttatcgc actgggcatc 1741021 acatattcaa aaacacttga tgtcattgcg gttagcattt atatggcggc gatttatctt 1741081 catgcatttt tggtgttcac ggcagctttt cgcaccaaga cggggacatt tcttattcgg 1741141 ctttcttccg ctgttttaat gataacgatt gctttctcga tgatttattc atttggtgtc 1741201 tttcggcaag aagttacatt gaccatcaat cagatgattt ggattcacgg ttttgtcaac 1741261 gcgtttggtg ttatcttgcc cgctctcata gggtggagaa tagaggatgc gaaacctttt 1741321 gatgcagaca gtgtaaagac attcagccgt atctacggaa aaagaaagat tggagaagaa 1741381 tttttagcta acattcaagc tgaaaataac gctcggtaca gcggacttgt ggatgatatg 1741441 ggcagcctgc gttcaaaaga tttttcacca gaaaaactgg cgccgctcat tctttcgttt 1741501 tatgaacaaa ccatcgaata caatattaaa gcaaaagtaa catggagcac gtggtttcgg 1741561 ccgcttgcaa ttatttacga atggttcagc agaagaatcg gccaaataca tctttcgacg 1741621 aaccctgact ggtataggat gtacagcaag ataaaaggtg ttcattcgaa aaaagacgga 1741681 agggaaagag tacgtgcctg gattagaaca aatgaaaaaa acgaaaccat ttttaccgct 1741741 ctttattcag tgtatcgttc aaatggagag gggtatatga atatttcttt accgcttcca 1741801 ttcagcagca tgacaggtat tttaaaacca tatcatcatc aggagaagct ggttttaaca 1741861 agcaggcgga gaaaaagcag agcgggggat gaggggattt atctgcaaac aagagcggga 1741921 acttgtccgc ttcctttatc tgaaaccttt ctgatagaag ctgtacatga caacaaatta 1741981 accgctgttc atcatatgtg gctgtttgga ataaaatttc taactgttca ttacagcatt 1742041 acacatatta accagcctat tgaaagaacc taacacaaag aagaagcttc gtctgccagt 1742101 tgtaatgaga tgaactgttt taaaattctg caccgcatca agacaggaaa ggaagggttt 1742161 atggtgtttt atatcagttt atttctgatt ctttggctgg ctgctgggtt tgcagtggga 1742221 atgaaacaag tgtatgtcga tcagctgttt gataaagctg tgatcgaaag actggaaaaa 1742281 gaagcgaatg atcatggaca tgctgaccgg atgatcaaac agcgcgtcct ttatattgca 1742341 gcagtgacag taagcgggtt tatttctgtt tattatgaaa tgaaaacaat cccgcaaagg 1742401 cgaaacataa gaaaaattga aaaaaacatc atgaaattaa atcaagcaaa aaaacgaaga 1742461 atgaagagaa aataaaaagt gcacaggcca aagggcaggt gcatttttgt tttgtatgga 1742521 aaatggggga ggtggtgcca gcttactttt cataaattca aaaatgagaa gaacagcgcc 1742581 cgggctaatg gtatataata ttgtgaattt aacaaaaatt taacaaggag gacgagagaa 1742641 ttcgtgctaa agcctcaaag agacctacat tctgttgatt tggacttaga ggcggagtag 1742701 atgaaaccgg ccaaagtatc cctgctccgc cgtttgctcc attccttgaa gcatgttgat 1742761 tgtaacatag ccaaacgttt tccatcaact attaaaattg taaaattatt gatgattttt 1742821 atggtgttta ctccgatttc ttcaatttat gctgaagatg tatatcagaa ttttgaggaa 1742881 ttaaaaaaca atgaagatcc ttctgattat ggcgttgtta cgaaagaaac cggaagccct 1742941 gttcttgttt tagctattca cggaggaggt attgaaggcg ggacaagtga agtagcgaga 1743001 gagctcagca aagagtactc gatgtattta tttgaaggct taaaatcggc aggaaactca 1743061 gtcctgcaca ttacgagcac acactttgat gaacctcggg cccttaaaat gacgggaaat 1743121 catgaatatg tcatttcatt acacgggtac gcagaagaag atcagcagat cgaagtcggc 1743181 ggtacagatc gcgtaagagc ggcagattta gttgagaaat tgcagcatgc cggttttcct 1743241 gctgtattgc tcaatatgga ccatccgcat gcgggcgtta gtccgaataa cattgcaaat 1743301 aaatcaaaaa caggtttaag tattcagata gaaatgagca cagggtttcg aaagtctttg 1743361 ttcggcatct tttctttaaa aagcagagct gttactcaaa atgagaggtt ttatgagttt 1743421 acagaagtga tgttccgttt tctcaaaaat agctactgaa aaataggagg cgataagaca 1743481 gcctcctatt ccttatgctt ctctttcgtt tcgggaaaca gctcgtccgc ggcttccgtt 1743541 tgatactgca acgtgttatc tctcgctgac agttcatttc ggaaattttc atcaagcaca 1743601 tttttcagta aataccgatg aaaaaagtat tcaaaaacag taagacaggc agcggaaagg 1743661 agagccgctc caaatggtga gaaatcgttt cttgtttggg ttaaaacaaa tacccaaaga 1743721 ataacgaatg aaaggccaaa gtcagccaat gaagctgtaa tattgtttgt tctgggtaag 1743781 acgagcatgt caccagaaag ataggaaaca aaacctaaga aaagtgcaat aaacatcaca 1743841 cttaaaaagg atgcgtgata gactctgtcc aaaatcacat ataaaagggc gagagtgaaa 1743901 gcaatctttg aagcaagcgc aatgatatgt ttcatttgac cacctaaatt gttatttttt 1743961 gaagaaaatt cttgggcgta aacaaatgat aaataatgca attcaaaacc attcataatg 1744021 gtcatgttac tattttaaac agtccgtttt tgtttacact ggtatttttt tcagctgtat 1744081 gaaactttct tatgaaaaaa gtcgtatatg tggatgatca gctttcaagg ggggaatgat 1744141 ttgtggagat aaaaggaatc aatcacttgc tattttcagt ttcgcatttg gatacatcga 1744201 ttgattttta tcaaaaagtg tttggtgcaa agcttttggt aaagggaaga acaactgcat 1744261 attttgatat gaacggcatc tggctagcgc ttaatgaaga accagacatc ccgagaaatg 1744321 acattaagct ttcttatacc catattgctt ttacaattga agatcatgaa tttgaggaga 1744381 tgtcagctaa attaaaaaga cttcatgtca atattctgcc tggcagagaa cgagatgaac 1744441 gcgatcgaaa atcaatttat tttaccgacc ctgacggcca caaatttgaa tttcataccg 1744501 gaacccttca agacaggctt cgatattaca aacaagaaaa aacgcatatg cacttttatg 1744561 atgaaacggc cttttgatag cacaaccata tttcatataa ggttaaattt aaagaagggt 1744621 gttggtggag actttatgtt tggggaaggt ttctacccga cttgttcaac gatgccatat 1744681 cttttgaact gcacaagtga ttgggtgaag gtgaaattga aatacacatt acattacatt 1744741 ttatatgaag aaagcgagct gttttatcaa atgttgaact aattaaacta tgtactaaat 1744801 tttcagtata tttcaattgc tttgcccctt aataaatata aaaccgcatc cttccacgac 1744861 ctaaaaaatg aaacgttttt aagaagatgg cgtctaatat tctaaatgtt catattttga 1744921 taaaagtttc ctaaaggaaa gaaaatttct tgacttcaac aatcttttgg tggataatta 1744981 tggtgtaaac atgatgttct ttttcctcct attcgggctc gcacccaaaa gtcagggcga 1745041 gcctgctttt tttgaacaac aaaccccctc tccgtaaagg aagagggggt tattttatgc 1745101 atctgataga tcaatagatt aatggacggt tctgaacacg ccaatcactt tccctagaat 1745161 gctgacattc tgcaaaatga taggttccat cgttgggttc tcaggctgca agcgaatgtg 1745221 ggtatcctct ttatagaatc gttttacagt tgcttcatca tcttctgtca tcgcaactac 1745281 aatttcccca ttgttcgctg tgttttgctg tttaacgatg acatagtcct tatcgagaat 1745341 accagcatct atcatactgt ctcccataat ctccagcata aatacatgct cgtctggagg 1745401 aaccatgcgg tcagggagcg gaaaatattc ttcaatattt tctactgctg taataggaga 1745461 tcccgccgtg actttcccga tgaccggtac attaacgacc tggctttgcg gaatgtctac 1745521 ttcttcatca agaatttcta ttgctcttgg ttttgtcgga tctcgtctga tcagcccttt 1745581 tgtttccaaa cgggccaaat ggccgtggac agtagaactg gacgcaagcc cgacagcctc 1745641 tccgatctct ctcacggaag gcggatatcc ttttgattta acctctgctt taataaaacg 1745701 gaggatatca agttgccttt ttgatagctt cgtcattttt cgcacctcaa aacgtcgatt 1745761 ttaagaagat tatagcatga ttttccttac agtacaaaca taggttcgaa aaaacaattg 1745821 acagaaacgt ttgttcgtat atactgaaat tataaaaatg cgaacaaaca ttcctgttgg 1745881 aggttatgat catgagtaaa gaatctatta tttttgtcgg tctgtttaca gtgattttga 1745941 gcgcggttat ccttatgctg tcatatacaa gcagcggcca agagcttaat cagtatgtta 1746001 aaatagaagt ccagcaaggc gacacactct ggtcaattgc tgatcaggta gccgatacaa 1746061 aaaagataaa caaaaatgat tttattgaat gggtagctga taaaaatcaa cttcaaacct 1746121 ctgatatcca gccgggtgat gagttagtga tcccattgaa aaagaagcat caggatgcat 1746181 atgaattagc aactgtaaga tagagaggaa agagagataa aatgaaagca ctcatttatg 1746241 cccgtgtaag cacaaataaa gaacagcagg aaacgtcatt aaagcggcag gaggaggagc 1746301 ttacggccat tgcagcggag aacggcatgg aagtggtcaa agtgatttca gaaaaagcca 1746361 gcggatatga aatggatcgg gatggtgtat ttgagctgct cgatgagatt aagaacgctg 1746421 atattgatgt cattttggtt caggatgaga caaggctcgg acggggaaac gcaaaaatcg 1746481 cactgcttca ttgtatttat agagaaggtg tgaaagtcta tacaacggct catagaggtg 1746541 aactggagtt atcggaggct gactcaatgg tcttggaaat cgtcagcatt gtggaagagt 1746601 atcagcgaaa gattcacaac atgaaaatca gacggggaat gaaacgtgca gtaaaaaacg 1746661 gttttaaacc gcaaaaaaac ttaaaaaacc aacatgggaa cagtggaaaa gaaaaaatag 1746721 aggtgccaat ctcagagatc gtccgcctga gagcgaataa actgacgttt gctgaaatcg 1746781 cggctaccct aagagggttt ggctatgatg tctctaaagc aaccgttcac cggcgttttc 1746841 aggaatacat agagaatgaa gagactgcag agtgaatcag ttgtaaaact ttttttgatc 1746901 tagtactata tagacaaaat gcaataaagg agtttaacat gatttcaaac gcgaaaattg 1746961 ccagaattaa tgaacttgct gccaaagcta aagctggcgt tattacagaa gaagaaaaag 1747021 ccgaacagca aaagctccgt caagagtact tgaaaggttt tcgttcttct atgaagaaca 1747081 cgttaaaaag tgtgaaaatc attgacccag aaggcaatga tgttacacca gaaaagctaa 1747141 aaagagaaca aagaaataac aaacttcact aatataagag gaatacggca atatcgtatt 1747201 cctcttttgc atatactata atcaaaactc ttatgtgaca aaattcaaca agtttctctc 1747261 aaatttaagc tgaaacagtt gagaaaaagt cgtcagacat ttatgatgta agggtacaac 1747321 acataaggaa ggggattttt atggatacaa ttgaaaagaa atcagttgct accattcgca 1747381 cactgtcaat agacgctatt gaaaaagcaa attctggtca cccagggatg ccgatgggag 1747441 ccgctccaat ggcatacacg ctgtggacaa aatttatgaa cgtaagtccg gcaaaccctg 1747501 gctggtttaa ccgtgaccgt tttgttttat ctgctggaca cgggtcagca ctattataca 1747561 gcatgcttca tttaagcggg tttgatctta gtattgaaga tcttaaggga ttccgccagt 1747621 ggggcagcaa aacaccagga catccggaat tcggacatac tgccggtgtt gatgctacaa 1747681 caggtccgct tggccaagga attgccatgg cagtcggtat ggcaattgct gaacgccatt 1747741 tagcggaaac atacaaccgc gattcattta acgtagtcga tcattataca tacagtattt 1747801 gcggtgatgg tgatttaatg gaaggtattt cttctgaagc cgcttcactc gcaggccatc 1747861 ttcagcttgg ccgtctgatc gtactatacg attctaatga catctctctt gatggagacc 1747921 tcgaccgttc attctctgaa aacgtgaaac agcgttttga agcaatgaat tgggaagttc 1747981 tttatgttga ggatggaaac aatattgaag aattaacagc ggctatcgaa aaagcacgcc 1748041 aaaatgaaaa gaaacctaca ttaattgaag tgaaaacgac aatcggattc ggttcaccta 1748101 accgtgccgg tacatccggt gttcacggtg cgccgcttgg taaagaagaa agcaaattaa 1748161 caaaagaagc ttacgcgtgg acatatgaag aagacttcta cgttccgtca gaagtttatg 1748221 agcatttcgc tgtagctgtt aaagaatcag gtgagaaaaa agaacaagaa tggaatgctc 1748281 aattcgctaa atataaagaa gtttatcctg aacttgctga acagcttgaa ctggcaatca 1748341 aaggagagct tccgaaggac tgggatcaag aggttcctgt gtatgaaaaa ggaagcagtt 1748401 tggcatcccg tgcatcttcc ggtgaagttc tcaacggact tgcgaaaaaa attcctttct 1748461 ttgtcggagg ttctgctgac ctagcgggat cgaacaaaac gactattaaa aatgccggtg 1748521 attttacagc ggttgattac tcaggcaaaa acttctggtt tggtgtacgt gaatttgcga 1748581 tgggtgcggc cttaaacggt atggcgcttc atggcggtct tcgtgtattc ggcggaactt 1748641 tctttgtctt ctctgattac ctgcgtcctg cgattcgcct tgcagcgtta atgggccttc 1748701 ctgtgacata tgtcttcaca catgacagta ttgcggttgg tgaagacggt ccgacgcacg 1748761 agcctgttga acagcttgct tcactccgtg cgatgcctaa cctttctttg atccgtccag 1748821 cagacggcaa tgagacagca gcagcatgga agcttgcagt gcaaagcact gaccacccaa 1748881 cagcgctagt gcttacacgt caaaaccttc ctaccatcga tcaaacatct gaagaagcat 1748941 tggcaggagt agaaaaaggt gcatatgtcg tttctaaatc taaaaacgaa acacctgacg 1749001 ctcttctcat cgcttccgga tcagaggtag gtcttgcaat tgaagcgcag gctgaattgg 1749061 caaaagaaaa tatcgatgtt tctgttgtca gcatgccttc aatggaccgt tttgagaaac 1749121 aatctgatga atacaaaaac gaagtccttc ctgcagatgt gaaaaaacgt cttgcaattg 1749181 aaatgggctc atcatttgga tggggcaaat acacggggct tgaaggtgac gttctcggca 1749241 tagaccgatt cggtgcatct gctcctggtg aaaccatcat taacgaatac ggcttctcag 1749301 ttccgaacgt agtgaatcga gttaaggcat taatcaataa gtaagctttt gaaagaggat 1749361 gagtcaaatc atcctctttt tcttgtttat ccgacaaaaa tagtattggc tgtttaacag 1749421 taatagacaa ttctttcttt tcttcttttg tataatagag agcaaatgaa atgctgctgg 1749481 aaaaggggat gaaaagatgg aacgtcacta ctatacgtac ctgatcaaag aggaatttgc 1749541 caatcactat ttcggccggg aatcggttat gtttgagctg tttcaagact atcattggac 1749601 aagccttgaa aagcagcagt atgaaatgac agagaaacag attcaatata ttacacaacc 1749661 aatcccgatt ttacatatgc atcagcggtt aaaaatgaat ttaaacaaga cggattacag 1749721 gcagctggat tatatttata gaatagcttt gccgaaagca aaaggccacg cgacgtttat 1749781 gatgaaggag cacatgatag aaattgtggc ttcgggagat tacgaggcag aaacgatatt 1749841 ctttgaagtg ttaagaaaag taagcccttg ctttttagca atggatttca attcgaagcg 1749901 ttacggatgg ctaaatccgg tgaaagaaag aaattttgtc taaaaccgaa gaaaaagaga 1749961 tgtaaatgtt gtataatagc ttttggttta gtacacttta aactagacaa catgaaggag 1750021 gaaataaaat gactttatgg gttggcatcc tagtgggcgt tgttgcattg ctcataggtg 1750081 ttgcactcgg gttttttatt gctcgtaaat atatgatgag ctacctgaaa aagaatccgc 1750141 ctattaatga acaaatgtta cgcatgatga tgatgcaaat gggaatgaaa ccttctcaaa 1750201 agaaaatcaa tcaaatgatg aaagccatga ataatcaaac gaaataatac gtaaagatta 1750261 tgatatagag aaacatggtt ataaaataaa aaacccttat acgggttttt tattttgcaa 1750321 tcattcatca cccgctactg ctcgaaggcg ctgcttttga tattgtatga gaagatggtc 1750381 aagctcctga ctgagctcta tcgtaatatg agatgtcatt ccgttcgcca tgacaatttg 1750441 cagcagctct gctctttttt tttcaatttc ttttaataga tgctctctaa tcacagggat 1750501 gtatcctttc atacattaga tcttcaaagt gaatgtttat attatatcca tatttatact 1750561 aattttcaaa tgagaaggag tataatgtct caatgtcaaa ttaaattata taagtttttt 1750621 ctgaaaatag aaatccttca agtgaaagtg ttaaaaaaat gaaatgattt tgtcataact 1750681 tgaaggaatg tcaaatcatg aagggatgat gacatgggag acgtgaatta ttttttgaca 1750741 ttcggagcgg ggtttttatc ctttatttcg ccttgctgcc tgccgcttta cccagctttt 1750801 ttgtcatata ttacaggggt cagcatggac gatgtaaaaa ctgaaaagct gctgctgcag 1750861 aaaagaagct tgtttcatac tttgtgtttt ttgcttggct tttcagtcat ttttattgct 1750921 ttaggctatg gaacatcttt tattggcagc ctgtttaggg attatcacga tgcgattcgg 1750981 caaattggcg cgttgcttat tattttgttc ggtttcatta cactcggtgt gttccggcct 1751041 gaggctatga tgaaagagcg gagaatccat tttaagcata aaccaagcgg gtttttaggg 1751101 tcggtcttaa tcggaatggc atttgcagct ggatggacac catgtaccgg tccgatatta 1751161 gctgctgtta tcacacttgc aggcaccaat ccgggctcag cggtgccata catgatgtta 1751221 tatgtactcg gttttgcggt accgtttctt ttattgtctt tttttatcac aaagctgaag 1751281 tggataagga agaaccagct tttcattatg aaagctggtg gcgttttgat gattgtgatt 1751341 ggtgtgctgt tattctttaa ttggatgagc ctgatcatta ttttgctgtc agatcttttt 1751401 ggaggcttta ctggtttttg acggtaaatt actttcgtac tactactaat ccttttgttt 1751461 ttggtacaat aagactatta tctgtggaaa tcgattgttg gaggggaata tgacaagagt 1751521 tttagttgta gacgacgcca agttcatgag agtgaaaatc agagagatct tggaagaggc 1751581 aaattacata atcgcaggcg aagcggcgga cggtgaacaa gcagctgacc tgtataaaaa 1751641 actgcgcccg gaccttgtga caatggatat tacaatgccg gtgaaaaacg gcataaaagc 1751701 gcttcgtgat atcttaacct ttgatcctaa agcgaaggtc atcatgtgca ccgccatgcg 1751761 ccagcaaaga attgtaacgg aagcaattga gctgggggca aaggatttta ttgttaagcc 1751821 gtttgaggaa acaaaagtgc tggaagctgt aagccgcgtt atgggacatt aaagtcattt 1751881 cttttcaaaa tggttttttt tattgttttg gagtatagta tatagtatca acactccgag 1751941 aaacaaagga atgataagta tgatgattat agtttcatca attattgctg tgttaatggc 1752001 tgtagctgtg atggtggtca gaataaagtc ctctgacaag cctgtttcac caaaaaaaat 1752061 cattcttccg ccgattttta tgagtacggg agcgttaatg tttttatttc cggtattttg 1752121 ggtaactgga gcagagtttt tggaagcatt cactttaggt gtgattttct ctatttttct 1752181 aatcaaaact tctaagttcg aaattaaaaa taatgaaatt tacatgaaac gctctaaagc 1752241 atttgttttt atattagtcg gtcttttggt gatcagaatc gtgatgaaat cgatcttgag 1752301 cacatcaatt gattatggtg cactgagcgg aatgttttgg attctggctt tcggtatgat 1752361 tgtgccttgg agaatcgcca tgtatttatc atatcgaaaa cttcataacg agctgcagtc 1752421 atctaatatt caaatgaatt aaaaaacctt tcctcttgtc aggaaaggtt ttttatttga 1752481 gaagggtctg ataaggttcc aaatcgattt ttttgtcccg cagatgcctt tttaagaagg 1752541 tatggtctct tttaggagtt gcgagaatat agcctttgat cataagttgc tgatcaatct 1752601 ttgctacctt ttcttttaat gcaagctcac cgattttgcc tgcgatttta gcttttgctg 1752661 catctctgaa cagctctggc acgggcgcag tcaattcatc tagaaactgt ttgttttcat 1752721 cgttccataa atgtctgctg ttttcaatat agtaatcctg ccaatcaagc tctgatctgc 1752781 cgtcctcttt tggtaaacgc tttaaaaact ttcgaaacat gaaaaaaccg ccgattgata 1752841 ataagactac catcatgatt acccaaaaca gaataaacca taaaaaccat ccttccagca 1752901 tcaatcattc ccccttattc taaccatatt gtatacgaag agagattaga agaacacagt 1752961 aaaaaaagaa tagaaaaaag tgatagacgt ctagtcaaaa gagatagtag atcatattct 1753021 attgtatagt gaatctgcta tttggccatg ggagagtcac tagagggtat ttgacgataa 1753081 atggacggaa aaaaagtcac tttcataata ggggatgaaa gtgacttttt atgtttagct 1753141 gagaggaaat tgaagagaaa aagaagagcc atcttctgtt tctttattga cggcgactgt 1753201 gagtatttga ttttcgcatt cgacttgaat gtttttgtca ttaaaataaa aaggaagcat 1753261 catttgtttt tcaaaagtct gtcctgacga tttgacagtt aagatgaact cgcatccaga 1753321 aagggtaact gttacttgtg taggctgtaa aaaagtcaga tccgcttcta taatatactg 1753381 ctgacttgtt tcatataaat caataggcaa tgtttcgtcg taccaggcga aggggtcttc 1753441 aaaaaattgc cgaagccatt catccatact atcgaaatca ttcgcatcgt tgcgttttga 1753501 atggttcatg gaagcattcc tccacatatc aaccttgctt tacatcatat gcggtggatt 1753561 ataaatgggt gaacgcataa aaaaacagac actaaggtct gcttttctta catatcatgg 1753621 cttgagttgt gcttttgtct tgtatggttt cggtttttta cttttttgct tccgcttaga 1753681 ggctcgggtt ggccgggatt gtgtccttta ggggcgtttt tatgcatatc tttacttgta 1753741 ttcttattgg tcataaaatg agaacctcct taaaagagtt cggtgttatt gattggtttt 1753801 tctttttttg ttattttggc gttctgcttc agtcagtaca agctggtcgt tttcaatata 1753861 gccggcgcct ttgccttggc tttttgcgtc attcattccg ttaatgacgt gattcgcttt 1753921 tcttttgacc atcattatca cctcaatcat aatatggctt cttttattgt gttatatgag 1753981 agagcgtaaa cagtaaaaat taccggtaca tttttctcat aagtcgaact tattgtattt 1754041 aataaaaaca ttgatattta cttatgtatg attttgtttt aatatgaaat tgtgagaaaa 1754101 ttgtgatgga atgtaatgtt catctgagaa tgatctgatc tgaaggggga ttttggagaa 1754161 tggcaaacga gcaaaaaact gcagcaaaag acgttttcca agcgagaaaa acgtttacta 1754221 caaatgggaa aacatatcat tactactctt taaaagcgtt agaagattca ggtataggaa 1754281 aggtttcgaa gcttccttat tccatcaaag ttcttttaga atcagtattg cgtcaagttg 1754341 acggcttcgt tatcaaaaaa gaacacgtgg aaaatttggc aaaatgggga actgccgaat 1754401 taaaggatat cgacgttccg ttcaaaccgt ctcgtgttat tttacaagac ttcacagggg 1754461 ttccggcagt agtagatctg gcttcactgc gtaaagcaat ggcagctgtc ggcggagatc 1754521 ctgataaaat caaccctgaa attcctgttg atctcgttat cgatcactct gtacaggtag 1754581 ataaagcggg tacagaagat gcattagcag taaatatgga cttggaattc gaaagaaatg 1754641 cagagcgcta caaattttta agctgggcaa agaaagcgtt taacaattat caggcagtac 1754701 cgcctgcaac aggtattgtg caccaggtca accttgagtt cttggcaagt gttgtccatg 1754761 ccattgaaga agacggcgag cttgtaacgt atcctgatac gcttgtcgga acagactcac 1754821 acacaacaat gattaacggt atcggtgttc tcggctgggg tgtcggtgga attgaagctg 1754881 aagcgggaat gcttggacag ccttcttact tcccagttcc agaggtaatc ggcgcgaaac 1754941 ttgtcggcaa gcttccaaac ggaacaacag ctactgactt ggcgttaaaa gtaacacaag 1755001 tgctgcgtga aaaaggcgtt gtcggtaaat ttgttgaatt cttcggaccg ggaattgctg 1755061 aactgccgct tgcagatcgc gcaacaattg cgaatatggc tccggaatac ggtgctacat 1755121 gcggattctt cccagtagat gaagaagcgc ttaactacct gcgcctgact ggccgtgatc 1755181 ctgaacatat tgatgttgtt gaagcatact gcagaagcaa tggcttgttc tacactccag 1755241 atgcggaaga ccctcaattt actgatgtgg ttgaaattga cctgtctcaa attgaagcaa 1755301 acttatcggg tccaaagcgt cctcaggatt tgatcccgct atctgctatg caggaaacgt 1755361 ttaaaaagca attagtcagc cctgcaggta accaaggatt cggtttaaat gctgaggaag 1755421 aaaataaaga aattaagttt aaactcctta acggcgaaga aacagttatg aaaacgggtg 1755481 cgatcgccat tgctgcgatt acaagctgta caaatacatc aaacccatac gtgctgatcg 1755541 gcgccggact ggtagcgaaa aaagcggttg agttagggct taaggtgcct aattacgtga 1755601 aaacgtcact tgcaccgggt tctaaagttg ttacaggata tcttgtgaat tcaggccttc 1755661 ttccatacat gaaagagctt ggctttaacc tcgttgggta cggctgtaca acatgtatcg 1755721 ggaactcagg tccgctttca ccggaaatcg aagaagcggt tgcgaaaaat gatcttctga 1755781 ttacgtctgt cctttccgga aaccgtaact ttgaaggacg tattcacccg cttgttaaag 1755841 gcaactatct tgcttcaccg ccgcttgttg tggcatatgc gctggctgga acggtaaaca 1755901 ttaacttaaa aaccgatcca atcggtgtgg gcaaggatgg tcaaaacgta tactttaatg 1755961 atatttggcc gtcaatggac gaaatcaatg cacttgttaa gcaaactgtt acgccagagc 1756021 tattccgcaa agagtatgaa acagtatttg atgacaacaa gcgctggaac gaaattgaaa 1756081 caacagatga agctttatat aaatgggata acgattcaac ttacatccaa aacccaccat 1756141 tctttgaaga gatgtctgtt gagccaggca aggttgagcc attaaaagga ctgcgtgttg 1756201 tcggtaaatt cggcgattca gtcacaactg accatatttc tcctgcgggg gcaatcggaa 1756261 aagatacgcc tgccggaaag tatttgcaag aaaaaggtgt ttcacctcgt gactttaact 1756321 cctacggctc ccgccgtgga aaccatgaag tcatgatgag aggaacattt gccaacattc 1756381 gcatcaaaaa ccaaatcgca ccgggtacag aaggcggatt tacgacgtac tggccgactg 1756441 gtgaagtaac atccatctat gatgcatgca tgaaatacaa agaagataaa accggtcttg 1756501 tcgtattagc aggaaaagac tatggtatgg gatcttcacg tgactgggct gcaaaaggaa 1756561 caaaccttct cggcatcaga acggtcattg cagagagctt cgaaagaatt cacagaagca 1756621 atcttgtatt catgggtgtg ctgccgcttc agtttaaaca aggtgaaaat gcggatacac 1756681 tcggcttaac gggtaaagaa gtcatcgagg tagatgttga tgaaacagtt cgtcctcgtg 1756741 accttgtgac tgtaagagca atcaatgaag acggcaatgt aacaactttt gaagcagtcg 1756801 tccgctttga tagtgaagtt gaaattgatt actaccgcca tggcggcatc cttcaaatgg 1756861 tgcttcgtga aaaaatgaag cagtcctgat gaatcaatag gaagagaagg catttcgctt 1756921 tctcttcttt ttatgacaca atgtgctgcg gaggtggcat atgctgaaaa aatggctcgc 1756981 agggatcctg cttatcatgc tagtcggtta tacgggatgg aatttatatc aaacatacag 1757041 caaaaaagaa gtcggaattc aagaggggca acaagcacct gatttttctt tgaaaacgct 1757101 atcaggagag aaaagctctt tacaggatgc aaaaggcaaa aaagtgctgc tcaatttttg 1757161 ggcaacttgg tgtaagccgt gccgtcagga aatgcctgcg atggaaaagc tgcaaaaaga 1757221 gtacgccgac aaacttgcgg ttgttgcggt aaatttcact tcagctgaga aaagtgagaa 1757281 acaggtccga gcgtttgctg atacttatga cttaacgttc cccattctga ttgataaaaa 1757341 agggatcaat gctgactata acgtgatgtc atatccaacg acatatatct tagatgaaaa 1757401 aggtgttatc caagacatac atgttggcac catgacaaaa aaagaaatgg aacaaaaact 1757461 ggatcttgat tagattcagt tttttttata ctcaaatatg cttacaagtt ttcagaattg 1757521 gaaaaaataa aagaatatgc ggaggtgaga agcgtgaaga agatgagaaa acgttctttt 1757581 catgagctcg tcatggaaaa caaaaaagag ctgatgacca atacagagta tttaaatcag 1757641 cttgaggaaa agcttgaaca gcgatttaag caaaaataac ctttaatttg tattcatgtt 1757701 tacccctcct tttgagaaac ctatctgttg aggagggata aacatgggaa acaacaagaa 1757761 aaacggtcag cctcaatatg ctccaagcca cttgggtaca aagcctgtaa aatataaagc 1757821 caataaaggg gaaaaaatgc atgatacttc aggacagcgg ccgattatca tgcagacaaa 1757881 aggcgagtag cgaaaattcg agtttatttc taggaggtac atccgaatga caaagaacca 1757941 aaatcaatat cagcagccta atcctgatga tcgttctgac aatgtggaaa aattgcagga 1758001 tatggttcaa aatacaattg aaaatataga agaagcagaa gcatcaatgg agtttgcttc 1758061 aggagaagat aaacagcgta tcaaagaaaa aaatgcaagg cgcgaacaga gcattgaagc 1758121 gtttcgtaat gaaatacagg acgaatctgc agcgagacaa aacggatacc gttcttaaaa 1758181 aaccagggaa acctggtttt tttctttctg atttgattat ggtaaaatgg ggctaaattg 1758241 acgttaaggg agcagagtaa tcttgcatgt atcaaaaaaa gaaatagaag tgcgttatgc 1758301 agaaacagat caaatgggga ttgtctatca cgcaaattat cttgtgtgga tggaggtcgg 1758361 cagaacggcc ttgattaagg acttaggctt tttatatagt gatatggaaa aaaaaggcgt 1758421 tctgtcccca gtcgttgata tcaatatttc ctataaaaag ccgcttcatt acggagaaac 1758481 cgcggttgta catacatgga tagaggacta taacggattt aaaaccgtct atggttacca 1758541 catttataat ccggccggtg agctttccat caaagccacc tcatctcata tttgtgtgga 1758601 taaagaaagc tttaagccaa ttcaattccg caaagctttt cctgattggc acacagcata 1758661 tgaaaaggcc aaaaaatagg gaagtgaacg ggatatggcg tttggtgtga aacgggagga 1758721 acttaaccgg tggaaacaag cagtgaaaag aggagaaatc gcatttttaa cacattactg 1758781 gctggatgac cgatttccag aagcaaagac cgtgacaaaa gccggctgtg cagacattga 1758841 taagctggtt cagtggggag cggcgtacgg gttaaaaaaa gaatggatcc ataagaaaag 1758901 tgaatttccc cactttgatc tgctggggga aacacaaaaa tatattttgg aacaagaaaa 1758961 cctaaccgat catcttatac gatttcattt gtaaaaaaag aacgcacatg aagtgcgttc 1759021 ttttttattg gtattcaaaa accggttcat cagcgtcttc tgaatagctg acgagaaggt 1759081 cgtggttatc aaagtaccat aaatcacttt cttcaataaa gaaggtaatg ccatcagctt 1759141 ctgcagtgac tccagcctct tgtggggcat ctttcgctac accgagagaa aaaccctttt 1759201 gaacgttgct gcagcctcca tagcggacga aaaagcgaac ctggtctccg ctttccaaat 1759261 cgagttcttc tttataccag ttcaatgcgt cttcgttaat tgtcatattc ataacagaac 1759321 acccctttgt tcttcatttg aattttctct attataaacg tattaggcta ttctgtgtca 1759381 aaagagaagt tttttaagct tataaccatt ttactttagg ttctgtttta ttgataattc 1759441 gtttaatgtt cgctcggtgt ctgtatatca caaaaatagt gagcagggta acgacaatca 1759501 ataaatacgt atcatggaca aagaaactat atataacagt atagatccct gttaacatcg 1759561 atgagagaga aacaaattta gtcaagtata aaaagatgaa gaataccgca accatcgtga 1759621 taaataacag gggtgcgtaa aatagcaaaa cgcctcctga tgtcgccacg gctttaccgc 1759681 ctttaaattt ggcgaagatg ggaaacacgt ggcctaaaac cgcaaagact cctgcaagaa 1759741 gcgggtgaat atcaacatgc atgagaaaag gcaatgcagt tgccagtgtc cctttcaaaa 1759801 tatctccggc tatgacgacc gaaccagctt ttacacccaa tgtacggaat gcattggtag 1759861 cgcctaagtt gccgcttccg tgctcccgaa tatcaattcc tttggcaagc ttgcccacaa 1759921 ttaagccaga tggaatgctg cctatcaagt aggccaaaat aatcaataaa gcaattaaca 1759981 tctacatttc tcctttttca aattcccttc tttttatttt aacatgagat gtcatgatct 1760041 gatgataagt ttttttgtaa agtttgctta caaatcaaat caaacatgca tcatattttg 1760101 atttctcctg ttttgatcgt gtaaaataag tgaaaaagga gtgacacacg atgcaaaacc 1760161 cttctaaagc ggaaattaaa gagattcttc aaagaagcaa acgtatagcg gtagtagggc 1760221 tttcagaccg tccggataga acgtcacata tggtttcaaa agcaatgcag gacgcgggtt 1760281 atgaaattat ccctgtgaac cctacaattg atgaggcgct aggtgtcaaa gccgtttcat 1760341 ctttaaaaga gatagacggt ccgattgaca tcgtaaatgt attccggcgc tcagaacagc 1760401 ttcctggagt ggcggaagag tttttagaga cagatgcgcc agtattttgg gcacagcaag 1760461 ggctagttaa tgaggaagca taccagatgc taaaagaaaa aggcagaacg gttatcatgg 1760521 atctgtgcat aaaagtggca cacgctgtaa caaaataggt gcagaactgc aaaaatcctt 1760581 gtaaattcaa ggatttttgc tttttaattt taagatattg tttgcgtatt acggtgaaac 1760641 agatacaata aagcttgaac agcttttttt gaataccttg tccagctggg tttcggccgt 1760701 tcgatttgcg aaggtctgct gctttatata taataaacaa acatacgttc tcatagtgta 1760761 aaaacagcac tagccgatgt tttgagaaga actgattcgt tagctctatg ttgcgattgc 1760821 aaacatattg gttataatga ggagtccaag gcagtactgg ctcgaggcga ggtttataaa 1760881 aaatatctta tatacaaatg atgtgtaaca ctgaaaagag aaagacaatg ttagtttttg 1760941 aaaggggttt gtacgtttgg ctagaaaaca gcaatttgat tacaacgaag atgccataca 1761001 ggtgctcgaa ggccttgagg ctgtcaggaa aaggccgggt atgtatattg gctctactga 1761061 cgcgcggggt ttgcaccact tggtttatga aattgtagat aactctgtcg acgaggtgct 1761121 tgccggccat ggagatcaca taatcgtcaa aatacataaa gacaatagta tttctgtaca 1761181 ggatagaggc cgcggcatgc cgaccggaat gcataagctc ggcaaaccaa cccctgaagt 1761241 gattttaacg gtgcttcatg ccggagggaa attcggccaa ggcggctata agacaagcgg 1761301 cgggctccac ggagttggtg catcagtcgt gaatgcttta tctgaatggc tgacggttac 1761361 cattgagcgg gacggttttg tctatcagca gcgatttgaa aatggaggaa aaccggttac 1761421 atctctcgaa aagatcggca aaacaaaaaa gacgggaact cttacacact ttaagccaga 1761481 tccaacgatg ttcagcacaa ccacttataa ttttgaaacg ctctctgagc gcttaagaga 1761541 gtctgcgttt ttgttaaaag gactgaaaat tgagctgatt gatgaacgca atgaccagcg 1761601 tgaggtcttt tattatgaaa acggcataga agcgtttgtt gcttacttaa atgaagaaaa 1761661 agacgtcttg tctgaagtgg tctcgtttga gggtgagcat cattctatag aagtggactt 1761721 tgcgttccag tttaacgatg gttattctga aaatattttg tcgtttgtca acaatgtcag 1761781 aacaaaagac ggcgggacgc atgagtcagg tgcaaaaact gcgatgacgc gtgcttttaa 1761841 tgaatatgcg cgaaaagtgg ctttgctgaa agaaaaggat aagaaccttg aaggcaccga 1761901 tataagggaa gggctttcag ccattatttc tgtccgcatt cctgaggagc ttcttcaatt 1761961 tgagggacaa acaaaaggaa agctcggtac cagtgaagca agatcagcgg tggatgcgat 1762021 tgtttcagag cagcttgctt actttttaga ggaaaatcgg gacaccgcaa cgcttcttgt 1762081 caaaaaagca atcaaggcga gccaggcgcg cgaagcggca cgcaaagccc gtgaagaagc 1762141 aagaagcggc aaaaaacgaa aaaaatcaga agcgacttta agcggaaagc tgacgcctgc 1762201 gggttcaaga aacccggcaa aaaatgaatt gtatctcgtt gagggagatt cagcaggcgg 1762261 gtcagccaag cagggacgag accgcagatt ccaggcggtt ctgcctttac gcggtaaagt 1762321 cattaataca gaaaaagcta agcttgctga tatctttaaa aatgaagaga tcaatacgat 1762381 cattcatgcg atcggcgggg gagtcggggc agatttctca atcgatgaca tcaactacga 1762441 caaaatcatc attatgaccg atgccgatac tgacggcgcc catattcaag tgctgcttct 1762501 tacctttttc tatcgctata tgaaaccgct cattgagcat ggcaaggtgt tcattgcgct 1762561 gccaccttta tataaggtca gtaaaggaag cgggaaaaag gaaatcattg aatatgcatg 1762621 gtctgatgaa gagatggggg atgtcctgaa aaaagtcggc aaaggctata ccattcaacg 1762681 atataagggt cttggagaga tgaacgcaga ccagctgtgg gaaacgacga tgaatccgga 1762741 gtcccgcaca cttgttaggg tcaaaattga cgatgcggca cgtgtagaga gacgtgtgac 1762801 gacgttaatg ggagacaaag tagagccgcg cagaaagtgg attgagaaaa acgtcgcttt 1762861 cggcttagat gaagaaagca atattttaga aaatgaaaac ttatcggtcg ctgaggaggt 1762921 ttaatgattg tcacagccag aattatttca tgatttacca ttagaagagg tgatcggcga 1762981 ccgttttgga cgctacagta aatatattat tcaagacagg gcgctgcccg atgcgagaga 1763041 cggattaaag ccggtacagc gcagaattct gtatgcaatg catacagatg gaaacacgtt 1763101 tgataaaaac ttcagaaaag cggccaaaac ggtcggtaac gtcatcggta actatcatcc 1763161 gcacggtgac agctcggttt atgaagcaat ggtgcggatg agccaggatt ggaaagttcg 1763221 taatgtgtta atcgaaatgc atggaaacaa tggaagcatc gacggagatc ccccggcagc 1763281 catgcgttat acagaggcac gattatctcc gatagcatct gagcttcttc gggatattga 1763341 caaaaacacg gttgaatttg tgccgaactt cgatgataca agcaaggagc ctgtcgtact 1763401 cccggcgatg tttcctaacc tattggtcaa cggatctacc gggatttcag caggatacgc 1763461 gaccgacatt ccccctcatc atctgggaga agtcattgat gctgtcatta agcgtattca 1763521 aatgccttct tgctctgttg acgaactcat ggaagttatt aaagggcctg attttccgac 1763581 aggcggtatt attcagggcg ttgacgggat aagaaaagct tacgaaaccg gaaaaggaaa 1763641 aatcattatc cgcggaaagg ctgaaattga aacaatcaga ggcggacgag aacaaattgt 1763701 cattactgaa attccatttg aagtaaataa agcaaacctt gtaaaaaaaa tggacgagtt 1763761 ccgtattgat aaaaaggttg aaggcatctc agaggttcgt gatgaaacgg atcgaacagg 1763821 gctgagagtg gtcattgaac tgaaaaaaga agctgatgcc aaaggcattt tgaatttctt 1763881 atataaaaat actgatttgc agatcacata taacttcaat atggtggcta tccataaccg 1763941 ccgtccgatg ctgatgagcc tgccgtctat tttggatgca tatatcggac accaaaagga 1764001 agttgtcaca aaccggtccg tttacgagct tcaaaaagca aaagacagac atcatatcgt 1764061 agaagggctc atgaaagctt tgtctatttt ggatgaagtg attgcaacaa tccgttcttc 1764121 tagcgataaa cgtgacgcta aaaacaattt gatcgcgaaa tatgaattta cagagcctca 1764181 ggctgaagcc atcgtgtcat tgcagctata tcgtttaacc aataccgata tcacagcgct 1764241 taaggaagag gcagaagagc tcggtaaaaa aattgaagag ctcgaatcta ttctgagcaa 1764301 tgataaaaaa ctgctaaaag tgattacaaa cagcttaaaa gcactgaaaa agaaatatgc 1764361 agatacgaga cgctccgtga ttgaagaaaa aattgaagaa attaaaatca atctcgaagt 1764421 catggttgca tctgaggatg tatatgtaac cgttacgaag gatggttacc taaaacggac 1764481 gagccagcgc tcatttgccg cttccaacgg tcaggacttc ggaatgaaag atacggacag 1764541 gatgctgcat cagtttgaaa tgaatacgac agacgtgctg ctgctcttta cgaacaaagg 1764601 aagctacatc tattgtcctg ttcaccagct gcctgatatc agatggaagg acatgggcca 1764661 gcatttttca aatctaatca ctattgaccg tgatgaaacg attgtaaagg ctataccgat 1764721 aaaagaattt gatccgtcgg catatcttct attctttacg aaaaacggta tggtgaaaaa 1764781 gacagagctc actcattata aagcacagcg ttattctaag gcacttgtag ccttaaatct 1764841 gaagggtgaa gatgaactga ttgatgtaca tgtaacaaat ggggaaagcc agatctttat 1764901 ggccactcac ttagggtatg gtctatggtt tggagaagac gaagtgaatg tagttggcgc 1764961 gcgtgcggca ggtgtcaaag ggattaactt aaaagaggat gactttgttg tctccggtga 1765021 gattcttcag caatctgatt caattgtctt gttcacacag cggggagcgg ttaaacgcat 1765081 gagtctttct gagttcgaga agacatcccg tgcaaaacgc ggtgtcgtaa tgctaaggga 1765141 actgaaaaag aatcctcacc gtgttgtagc actgttcgct tgcggtcttg aacagcgact 1765201 aatggcagaa acagaaaaag gcgacagaaa agaactgcag acaaaagagt tgcggacaaa 1765261 cgacagatac agcaatggct ctttcttttt tgatgaagag gaatcaggca aggttacagc 1765321 tgtttggcgc cttcatacag aacaataata aaaaacccgc tcatactata tgagcgggtt 1765381 tcgtttgttt tttatcagct ttcatggttg gtgaatagat ctgttacagc atgaatgact 1765441 tcaatcccct gccatacaaa taaattcagc gctgtgaaag aaaataagcc taaaatcacc 1765501 attcttaaga taaacaacat gtttaacagc ctcctcatat tttcgttaca taatcgggtg 1765561 atgttgaaca tgaagtttgc cgaaataaga cgattgataa aatttggcca gtataaagct 1765621 ttttttccgc tgacgtctgc gggagtatcc cgtacttttg ctttcagcgg tcagcagcag 1765681 aacagccatt gcccataaag cggtcagcgt aaatgcccct gtgatggatt tcttctcatc 1765741 atcagcattt tggccggctt tcatctcatg catttcctgc tggtcggcta cggctttata 1765801 atgatggccg atatcaaagg cgtggggaat tgagaacaaa tgaaaactgg caatcgccaa 1765861 gaataagatg gatgctttca atatcgttac ttttttcaaa tgatctcccc ctcctttaat 1765921 attactgaat atttttataa taatacccca atccatccta aaagtaaacc tgatttatta 1765981 aatttaaaaa taaatttaac tttgttaagt atatatcttt ttgcttattt ttgaaagaga 1766041 aaacttcttt tattagcgta tgtatacccg gtttatggtg tgaataaaaa catattttaa 1766101 atgatatgtt gtttaggatt tattacttta tttatgtgta aatcaaagag aaaggcaaga 1766161 gaatgggaag aaatgattac attgttaata gggtactctt tttttaaagc cagtttgcaa 1766221 ggaatgtttt tattcgtagg aaaataatag agaaggggtc gacagagtaa catctggcta 1766281 tgacaatatt cttctcgaaa aaacttccta attcgtcata ttgtgatata ataaaactcg 1766341 ttatgttaaa aaatctaaca tcaaaatcga attcgtattg aattgatgaa aacgggaggt 1766401 aaatatggag tcttttttca atagtttgat taatattcca agtgatttca tctggaaata 1766461 cctattttat attttaatag ggcttggatt attttttacc atacgttttg gttttatcca 1766521 attccgttat tttattgaaa tgttcagaat agtaggggag aagccggaag gaaataaagg 1766581 tgtttcatct atgcaggcat tctttatttc ggccgcatcc cgagtcggca cagggaattt 1766641 gactggtgta gccttagcaa ttgcgacagg cggaccaggc gctgtatttt ggatgtgggt 1766701 agtggctgca gtaggcatgg cttcaagctt tgtcgaaagt acattagcac agctttataa 1766761 ggtaagagac ggggaggatt tccgcggagg gccggcctac tatattcaaa agggtcttgg 1766821 tgccagatgg cttggcatcg tttttgcaat cttaattacc gtctcattcg gcttgatttt 1766881 taacgctgtt caaacaaata caattgctgg agcattggat ggcgcattcc atgtaaataa 1766941 aatagttgta gccatagttc tggcggtttt aactgcgttt atcattttcg gcggtttaaa 1767001 acgtgttgtc gctgtttcac agctaattgt gccggttatg gcaggcattt atattcttat 1767061 cgctttattt gttgtcatca cgaatattac ggctttccct ggcgttatcg ctacaattgt 1767121 taaaaatgct ttaggttttg aacaagtcgt cggcggcgga ataggcggca tcatcgttat 1767181 cggtgcgcaa cgcggacttt tttcaaacga agcaggaatg gggagcgcac caaacgcggc 1767241 tgcgacggct catgtatccc atccggcaaa gcaaggcttt attcaaacat taggcgtatt 1767301 tttcgataca tttatcatat gtacgtccac agcatttatt attttgctgt acagtgtaac 1767361 gccaaaaggc gacggcatcc aagtcacaca ggctgctctt aaccatcaca ttggaggctg 1767421 ggcgccgact ttcatcgcag tcgcaatgtt cttgtttgca ttcagttcag ttgtcggcaa 1767481 ctattattat ggcgagacaa acattgaatt tattaaaaca agcaaaacat ggctgaacat 1767541 ttaccgtatc gctgttattg ctatggttgt gtatggatct ttatcaggct tccaaatcgt 1767601 ttgggatatg gcggacctct ttatgggtat catggcgctg atcaacttaa ttgtgattgc 1767661 gctgctgtca aacgttgctt acaaagtgta taaagattac gcgaaacagc gtaagcaagg 1767721 acttgatcct gtgtttaaag cgaaaaacat cccagggctg aaaaacgctg aaacatggga 1767781 agatgagaaa caagaagcat aatataaata taaaacaaag ctgcattcaa tagttgaatg 1767841 cagctttttc attattggaa ataaatttaa tttttcgact cgaatgaaaa atgacgtgta 1767901 aagtcccaat tcagtccagt tttctttgtt ctatatgtgt catgtgtgtc ttattcattg 1767961 gaggtagagc aaattgacag gcttttaaac ctccccaaaa caagaaatta ggttgataga 1768021 caatcatgag aaagattttt acaatgagtt cgtgctcata agaagtgtag agccaaaatg 1768081 atgcgaagga ggaaaagatc agatatgaaa cggtcaatct ctatttttat tacgtgttta 1768141 ttgattacgt tattgacaat gggcggcatg atagcttcgc cggcatcagc agcagggaca 1768201 aaaacgccag tagccaagaa tggccagctt agcataaaag gtacacagct cgttaaccga 1768261 gacggtaaag cggtacagct gaaggggatc agttcacacg gattgcaatg gtatggagaa 1768321 tatgtcaata aagacagctt aaaatggctg agagatgatt ggggtatcac cgttttccgt 1768381 gcagcgatgt atacggcaga tggcggttat attgacaacc cgtccgtgaa aaataaagta 1768441 aaagaagcgg ttgaagcggc aaaagagctt gggatatatg tcatcattga ctggcatatc 1768501 ttaaatgacg gtaatccaaa ccaaaataaa gagaaggcaa aagaattctt caaggaaatg 1768561 tcaagccttt acggaaacac gccaaacgtc atttatgaaa ttgcaaacga accaaacggt 1768621 gatgtgaact ggaagcgtga tattaaacca tatgcggaag aagtgatttc agttatccgc 1768681 aaaaatgatc cagacaacat catcattgtc ggaaccggta catggagcca ggatgtgaat 1768741 gatgctgccg atgaccagct aaaagatgca aacgttatgt acgcacttca tttttatgcc 1768801 ggcacacacg gccaattttt acgggataaa gcaaactatg cactcagcaa aggagcacct 1768861 atttttgtga cagagtgggg aacaagcgac gcgtctggca atggcggtgt attccttgat 1768921 caatcgaggg aatggctgaa atatctcgac agcaagacca ttagctgggt gaactggaat 1768981 ctttctgata agcaggaatc atcctcagct ttaaagccgg gggcatctaa aacaggcggc 1769041 tggcggttgt cagatttatc tgcttcagga acattcgtta gagaaaacat tctcggcacc 1769101 aaagattcga cgaaggacat tcctgaaacg ccatcaaaag ataaacccac acaggaaaat 1769161 ggtatttctg tacagtacag agcaggggat gggagtatga acagcaacca aatccgtccg 1769221 cagcttcaaa taaaaaataa cggcaatacc acggttgatt taaaagatgt cactgcccgt 1769281 tactggtata aagcgaaaaa caaaggccaa aactttgact gtgactacgc gcagattgga 1769341 tgcggcaatg tgacacacaa gtttgtgacg ttgcataaac caaagcaagg tgcagatacc 1769401 tatctggaac ttggatttaa aaacggaacg ttggcaccgg gagcaagcac agggaatatt 1769461 cagctccgtc ttcacaatga tgactggagc aattatgcac aaagcggcga ttattccttt 1769521 ttcaaatcaa atacgtttaa aacaacgaaa aaaatcacat tatatgatca aggaaaactg 1769581 atttggggaa cagaaccaaa ttagttaagc ttttttttgg cggacatcag taacgatgtc 1769641 cgtttttatc atctaatagg aggtttgcgt tgtggatgaa atactgaaac agtatatggt 1769701 gctgtataaa aaaatgagta atatgataaa tggtcccgac tatccaggta aggaaaaaga 1769761 catccagcat caaaaagatc agatcgaagt ttacgaaaaa cagctgcagc aaggattttc 1769821 tacagattat gactatgatg tgtttgctga ttctgttatc aaatgcgcat atggcgatat 1769881 gacgctggaa gatttagaag ccgtttatta tggattgaca acaccatttt tttgatttgt 1769941 cattcagcag taaaatttca atttctgtct cactaactta agtatacttt gatattgaga 1770001 cagaaattta tttattttgt ttacttccta gaatatatat tatgtaaact agaaaagatg 1770061 aagaataaag ctttgctgtt tttatgtaca tcctttcttc ttcctgtaat tcagcaacaa 1770121 aataaaaaag cgatttccca atcggaaaat cgccaattca gacactctat tatttatgtg 1770181 tgtctttgtg ctcttaacga tttacaacaa atgttgtcac gctttgagct ggaagatgag 1770241 cccaaaaatg attgcctgat acagtgagat tcgttccagg ttgtagattg ctgctgctgc 1770301 tcgtgatcca tctagatacg tttgaagcag atccattctg caaaacaaag ttttggttga 1770361 ctcctgtgtt gcttttattg atggcaacaa taacgacctt gttgtcacct ttataggctg 1770421 acacgtaaac gttcgcatta gggtttttcg ttgcatcaat ccttacatag ccgggacgca 1770481 caaactttga gaaatgagcc atattgtagc cgcgtttgct gatcgtacca tcttctttca 1770541 taggtccata tgatcttcgg atgtaccacc atacataagc ttgaaagtcc ccctctacca 1770601 tcgcattgtg aatatgctgt gaaacatcca atgcctcagg ccatcgatcc gccgagttgg 1770661 tatcactgtt tggatagtat acttccgtca tccaaaggtc cttccccgct cctttttgtt 1770721 tgaaaagagg ataagggaat tggctgacct gggtgccgta caggtgagtt ccgagaatat 1770781 ccatattggc aagagcctgc ggatcgttca agatcgggtc cgacaaattc ttcaagtatt 1770841 gaaatgactc aggcgcaatg acgcgggcat tgatcgagcc ggcgttttct ctcataaagc 1770901 gaagtatttc ttgcggcgtc caccacgtcc actcgtgagc gtaatcaggc tcgttttgga 1770961 ccgaaatcgc gtaaagattc acaccattat tcttcatgaa ggtaacaaaa tcgttaagat 1771021 gctgcgcgta tgctgcgtac ttgttgtatt tcagccgttt agccgatgtg tcaccattcc 1771081 gattaaaggt ctcaaccata tcacttggag gattccaagg agaagcaaaa acgattgctc 1771141 cgtgtttgac cgcactcttt gcagtctcca cctctttata ccaattattt cgattttcat 1771201 ctacatgaat tcttaagatt gaaaatccta actggttctg tccattgcca aaagcagttt 1771261 ctctttgagc tgctgtaaga tccccagccc aagccggatg attcatccct ccaaaaccgc 1771321 gaatcacttg tttctctgca gatacattaa ctgttacatc acttgctgcc aaaacttcag 1771381 tagcgcctgg ccctaacatg actgacagca tagtgaaaca tactaatagt acacaaattg 1771441 ttttttttat gcgtggaatc atttattcct ctccttcgtc atgtgtcttt tacggtatta 1771501 aaaaatctgc atggcatatc cataatggcg ggctgttccg gtgctggccc gtacttcacc 1771561 cgcctcgttt ttaagcggtc ccattacgag tactatcttt gcgtaaactg ccagtaatca 1771621 aaattaaaca agtttcctgt acctgttccg gtaaatacaa agaatacttt gtgcacaccg 1771681 gttgccccgc ttaccgcagt ttctatttcc ctccacgttt gcgctccgcc tgttgaaggc 1771741 acattcagag ttccaacaag cttaccgtct gcactgtcga ggcgcacttc tattttcccg 1771801 cctaaagtgg atgctacatt tgctttaaat gacctggcac cgcccgctcc gaagtctgca 1771861 tttcctacag caatccagtc tccattttga atgcttgtta catgctgatt atttactggc 1771921 ccgccgggtg ctgtggactt ctctgtcaaa atgcgtccat tccaagcaaa cgtttcagct 1771981 tctacccggt tatatgggtt taaattggaa atttgtgtta cacctgcata atttgccgct 1772041 acctcttgaa tagatccatc tgcattatgc accagcttat taatatgggg agagcggtat 1772101 cctttgccgg ccccgaacag agcggaactg acagtttgcg catggtacac cacataccac 1772161 tcgtttttaa aattgaaaac agcatgatgg ttgtttccgc cacctccgaa aaatgcaccc 1772221 ggatttttca ggaagtgccc tctatatgta aagggaccca tgggacttga actggtcatg 1772281 tagccgatct cacccggggg tttatcggcc gggtgcgtgc cgccgaaatt gatgcaatag 1772341 gagtaataat atgttccgtt atacttgtgc aatcccgaat cttcaaacat gaaaggcgca 1772401 tcaattgtag atgcacttcc aacaacactc gtcatatcag gccccaattt tatgactcta 1772461 gccgttttag gattggccca ttgtccctgc gttggatttg aaacgccagg aacgcctccg 1772521 ccggcataca ggtaaccggt tccgtcgtca tctacaaata ctgccggatc aaaaagccat 1772581 acaacaccag acattcctgg cgtacttggc gttacgagcg gttttccgat tgggtcggtc 1772641 catggaccaa tcgggctgtc tgcggtgaga accccgatac ctccgccgct gtttgcgaaa 1772701 taaaggaaga atttatcctt gccattaatt tttttaactg cgattgacgg tgcccatgac 1772761 gcacctgccc attttgcaat tccacggcct ccattagctc cattggcacc tgctaccgga 1772821 atggctccgt ggtctgtcca gttcaccata tccgctgaag atatgacgaa tactctattc 1772881 aaattggcaa atgaattatc tttaattgtt ccgttgctat tatattcata gtcatcactt 1772941 gacatataga tgtagactct tccgttatag gtcagcgcaa ccggatccgc tcccaaatga 1773001 tggtcgataa gcggatttga attccctata tgttttgcaa ttgtagtact agtggcagca 1773061 tacgcagact tcccagataa gcagctcaat aataaaacta gaatccataa acatacgcta 1773121 cactttttcc tcatcacttc acatcctcct ttttccttaa aatgggggat tttcttttgg 1773181 aatttgataa caacaggtca cgaagattgc acgcataaag tagccggaag ctgtttagca 1773241 atgttcccag ttgttctgaa agctcatctt catgtgtctc cattctctct tttcttcgag 1773301 gagatcgcac cactccttca aaattgttca aaaaaacttc cccattccta gcgaccattg 1773361 tccagaaaat aaaaagacag gattgttcat ggcctcccac taatcacatt gaacggagat 1773421 tacatcatta tccaagatat ccctttatct aacatcctac atcattaaaa aaattgtgta 1773481 tagaaacttt tggaggagtt agtgttcgat tctacaaagg aactggatac atttattcat 1773541 tgataagatg gggctaacac tccgtttata tttgtatgtt ttcagacaca aaaaacagcc 1773601 gttcaatgcg gctgtttttt tcaagagtat aagactattg agcggtatac ccgctttttc 1773661 atgttttgtt catattttat taattgttta ttcaacactg tccgctatag taatccatat 1773721 caacaaatat gactgccact cgcatctttt atgaagggag gttcgttacg ctgaaagaaa 1773781 aaataaagac attaggccgt ttttgcaccg taggcgtcgg caatacgctg atagattttg 1773841 gtgtcttctt tcttcttacc gcttgtcatg tctcttatct gccggcgcag atctgctcct 1773901 atactgcagg tatcgtcaac agctatgtgt ggaaccggaa ttggacgttt tgtgtgaaac 1773961 gtaaggctga cgggaaagag atcgtgcgtt ttctcatgat taatattgcc gcgtcaggga 1774021 tcaccttttt gctgctttat ttgtttcaaa attgcggctg ctcgcttttg gtgagtaagc 1774081 tcgccgccac tatcggcgga atgatgatga attttatcgg aaaccgaatc tgggtatttg 1774141 gagattcgct gaaaaacata caggatcagg agtgaagatg aatgagaaaa aaagtgagaa 1774201 aagcggttat acccgcagcg ggtttaggaa cgagatttct gccggcgaca aaggcgcagc 1774261 ctaaagaaat gcttccaatc gtcgacaaac cagcaatcca atatattgta gaagaggccg 1774321 cagagtcagg aattgaagat atactgatta ttacagggag aaacaaacgc tcgattgaag 1774381 atcattttga tcggtcggcg gaattggaat tcaatctccg ggaaaaaggc aagacggaga 1774441 cacttaagga aatgcagcag attgccgatt tggccaacat tcattacatc cgccagaaag 1774501 aaccgctcgg attaggccat gcggtgctgt gtgcggagca ttttatcgga gatgagcctt 1774561 ttgctgttct cttaggtgat gatattatgg tgtctgaaac accggctctt cggcaattaa 1774621 tggatgtata tgacgtttat ggcacagagg ttgtcggtgt acagtcagtt ctccctgagg 1774681 atgtcagcaa atatggtatt ataaatacat cagggtctca agggcatgta tatgaagtga 1774741 acgatttagt ggaaaagcct tctcctgaag aagcaccttc ggaaatcgca gtaatgggac 1774801 gttatgtgct gaattcttcg atcttctccg ttttgaagac aattggcaga ggcgcgggca 1774861 acgaaattca gctgacagat gcgcttcgtg aggtttgccg taaggagccg atccatgccc 1774921 ggctgctgga aggaaatcga tatgacattg gcgataagct gggctgtttt aaagcgagca 1774981 ccgaaatcgg cttaatgcgt cccgaaatga gatctcagct tttggcctat ttagaagatg 1775041 tgatcaaacg ggaaacgaaa gaaatgctgc ggtaaaaaaa ttgtaaccat cttgctcgtc 1775101 aatcagtcat ataatagtga aaaagattag gacaggttgt gaagaatgtg ggcagtttga 1775161 taagcgaaat tttaacatgg ctgacgaaca tgggatatgc gggtattgcg attgggttaa 1775221 tgattgaaat cattccgagt gagattgtat tagcttatgg cggctatatg gtatcggagg 1775281 gcacgattgg atttattggc gcaattattg cgggtgttat cgggggcacc attgcccaga 1775341 tctttattta ctggatcggt cgctatggcg gcaggccatt tctggacaaa tacgggaagt 1775401 atttattgat taaaaagcat catatcgata tgtcggaaaa ctggtttcag aaatacggcg 1775461 ccggagttgt cttctcggct cgttttatac cggttgtcag acatgccata tccattccgg 1775521 caggtattgc cagaatgcct tttctcaaat ttgtggtact gactgtgctt gctatcattc 1775581 catggtctat cctgtttgtt tatttaggca tacagctagg aagccagtgg gatgatgttg 1775641 agaatatagc aggcacttat acaacaccga ttatgatatt ggctgttgtc gtgatagccc 1775701 tttattttgt gattaagaaa cgtacagcca tatttaaacg atagctagcg gatatgcata 1775761 ggggtgactg acgctcccct atgcatattt ttttacttgc gatgttgatt tgccagcttc 1775821 agattctccg ctaaaaatgc gacaaacact tcatcccgca cgagcgatgc ggcataattt 1775881 ctcttaataa accattctgc ctcttcaaac gctgcgaatg tttcgtcttg ggtttctccg 1775941 ttaatttgaa tattccattc gttgtctaaa gggaaaagaa aaaatctcat ttgtgcgcga 1776001 ttttcatata atgatccatt cgcagatccc tttagattat agatgttacg gaaggcatcc 1776061 ggccgtacag gatcaatacg gaaagcttca gctacaaaca actcgtatac ttcatcggtt 1776121 attgaacagc cggacgcttt tgcatgccct ccgccgccat atcggccggc gatttctgac 1776181 acatcgatgt aatcatgaat ggtgcggaga ctgactcgtt ttgaccccat gctcaaaatc 1776241 gcaatgtaat cgaggtgcgg gttatctttc cctagcctgt tccccagctc tgaatggtac 1776301 gattcagcgt gaacgatgcc tacacagtgt tcgtgaacaa aggtttgtac catttccctt 1776361 ttctttctgc ggaggtagcg ctcgattttt tcgtcttcta aatcaagcag tttttcttca 1776421 aaatcatcga agaaaaattc gtcatgcgtg gaaaggcgct ggatcatttt tgcttcaaat 1776481 tcatcgattg acagcaaaaa gaaaagatca ttaagccgct tcgcctgttt ttgatcgtac 1776541 cgctcccact cccatgtatc gtattggcgg acgagctctg tgaattgatc taaggcgttt 1776601 gtcggtttca tgaagccatt ttcaatgaga tagccatata aaagcgatgt cgcggatgtg 1776661 agccttccat catcgtattc cacctggaca aatccccatt catgctcatt caaatgaagg 1776721 gctgttttat gatggtcaat gagcttcact ttgccccctg catgaacata ctcattcaat 1776781 ctctcttcgt tttcttcatt gacggcgaga tcggtgatga ataacgcgtc ctgtctgttg 1776841 ctctccttcg ctttttctaa aaagtactgc acctgtgcgt ttaagccgtt gacagagtta 1776901 taccggatct ctacgtcttt tccgaacgcc aattttgcta cgattccgca tcctactccg 1776961 tccaagtcgt tatgtgaata taaatgatac ataatgtagg ccccttttta tgataaactg 1777021 acaattgccg ctagaggtgc ggcagccttt atttactatt ctaaaaaacc aagcgtttta 1777081 tgcaatggta attagttgac ataatgttgt tattgtaaat atataaagga gcgctttttt 1777141 tgcgctccta agttcttgct tttacaccgg ataaaccgga tgctttcgat tggtaaatgt 1777201 catttccttt gtcatgtatg ccttgagccg tttggccagc tcatcacgca gcgaattggc 1777261 tgggataaca gcatcaatga tcatttctga agccagacgg tagatattga tgtcctcttt 1777321 gtattcctcc cgtttgctgc tgataaatgc ggctctctct tcttctggca gctcggcgat 1777381 ttttttagcg tagacagcgt ttacagcggc ctcagggccc atgacggcga tttgggcggt 1777441 tgggagcgct agacagcaat ccggttcaaa tgccggccct gccattgcat acaaccccgc 1777501 cccgtaagct tttcggacaa tgacagagag ttttggaaca gttgcctccg acatcgcaga 1777561 aatcattttc gctccgtgtc tgataatccc agcctgttct acttttgtgc caatcataaa 1777621 accggggata tcggctaaga acagcaatgg gatatgaaaa gcgtcacata aggtaataaa 1777681 cttagccgct ttgtctgctg aatcgtggaa taagacgcct ccttttacct tcggctggtt 1777741 tgcaacaatg ccgacaggct gtccgtggat tcgtgcgagg cccgtcaata attccggtgc 1777801 aaataaggct ttgatctcaa aaaatgagtc ttcatctatg acccgctcaa tgagctcatg 1777861 catatcaaaa ggtgcgtttt gattttgcgg aatgacgtcg gcaagcggag tttcgaagtg 1777921 ttttggcggg cgtttctcat gaatgggcgc tttttcttga aaatttgccg gaaagtaaga 1777981 caaataagcc cgcaccagct gtatggcttc ttcttcagtt tctgcaagaa tatctccgca 1778041 gccggagatt gagcaatgca tacgggcgcc acccatttct tcgagagaca ctttttctcc 1778101 aataaccatt tccgccatcc ttggcgaacc taaatacatg gaggcgttac cgtctaccat 1778161 aacgacgata tcacagaagg ccggaatata agcgcctcct gccgcagatg gtccgaaaag 1778221 cagacagatt tgcggaatgc gtcccgataa tttgacttga ttgtaaaaaa ttcttcctgc 1778281 accgcgtctc cctggaaaga cattgatttg gtcggtaatt cgggcgcctg ccgaatcgac 1778341 taaataaatg agcggacagt ttaatttttc ggcgatttct tgaattctga tgattttttc 1778401 aactgttttt gctccccatg accccgcttt cactgttgaa tcattcgcca tgacgcaaac 1778461 ggtttggccg ccgattttgc cgatagcggt tacaactccg tcagcgggaa gcccgtctga 1778521 catacattcc gcaaaaaaag cgtcttctag ctcaatgtca tcgtcaaaga gaagggaaag 1778581 ccgctctctg acaaagagct tgcctttttc ccgattgctt tgatgatact tttccgctcc 1778641 gccttttcga atccgttcag cccgttctgt tcgttccttt tcataatcca tcagcattgc 1778701 ctccctttta tattcccttg tatacggccc gtcttttttc ttgaaaggcc tgaagccctt 1778761 ctctcctgtc ttttgtcggg atggtttgtt catacgcttt ttgttcaatc gcaaggcctg 1778821 tagcaagatc tgtctccaat cctttattga ttgcaaattt agcctgacgg acagcgatcg 1778881 gtccgttggc agaaatggct gcggccagtt cctctgcttt tggcataagg tcacaaggag 1778941 ccgtgacatg ctctacaagg ccgatttctt ttgcttcgtg tgcggtcacg cgtctgcctg 1779001 tataaatgaa ttcttttgct tttcctctgc caatcagccg gggcagcctt tgggtccctc 1779061 cagcgcccgg gataatagct aaccctgttt ccggaagtcc cagcacagct gcttcagttg 1779121 cgattcgaag gtcgcatgcc aatgccaatt ctagtccgcc gcctaatgcg cttccattta 1779181 tcgcagctat gaccggctgc ggcaaggcat caagtaaagc cgccgttctt tgaatgagag 1779241 atacactttc cagaacctga tcttctttca gttttatccg ttccttcagg tctgcccctg 1779301 cacaaaacgc tttttcaccg gtgcctgtga ggatgacgca acggatgttt gagttaaatt 1779361 caatttcctg gataatcatt tgcaggtttc taagcatttc cgctgaaaga gcatttgctg 1779421 cctgaggcct gtttaaggtg atcaacgcca tatgttcatt tttaacagta aaaagaatag 1779481 aatctcccat tgtatgcgtc ctccctttta tcaagatgat ttaaacacct gtaaatttct 1779541 gctcggcagc ggtttgccca ttttttcttc aatccatttg gccgcagata gcagtttttc 1779601 tagctttaca tttgttttga tatccatctg ttcaagcatg tacacgatat cctcagttgc 1779661 ggcgtttcct gatgaacctg gcgcatatgg gcatccccca agcccgcctg ccgagccgtc 1779721 gaacaccgtg atgcccattt ggagtgctgt gaccatgttg gccagagcgg ttcctctcgt 1779781 atcatgaaaa tgcagggcaa tttgattagc cgggaatcgt gccaaaagag cttcaagtac 1779841 agtttccact tgggcgggat tagctgctcc aatcgtatct ccaagcgaca gttcagaaat 1779901 cccaaattca aatagagctt ctgaaaggcg aatgacttgt tcaatgggga catctttttc 1779961 gtacggacag ccgaaaacag tcgagaggta ggctcttgtt gtgaggtttg ctttttgtgc 1780021 gtcgttgttt acttgtttga gtatatggag ggattcagaa gtggatttat tgatgttttt 1780081 tctgttgtgc gtctcgctgg cggacataaa aacgcaagcc tcgttaatgc ctccttcaag 1780141 tgcattctcc agtcctcttt gattcgggac aagtgccgcg tacgttaccc ctttttctcg 1780201 gtcgatgcct tttgctacat cgatagcatc tcgaagcgcc ggaatccatt tcgggtgaac 1780261 gaaggatgtg atttcaatat acgacagccc tgtccgggaa agctggttga tccaggttat 1780321 tttatcctct gttgcgatcc aaacgggctc gttttgtaag ccatcacgcg ggccgacttc 1780381 tttgattgtc acttttttag gatatggcat ggtcttcctc caaattattg agtggaattg 1780441 ctcagttcga gcagtacgtc tccttcattt acaaagtcgc cttccttttt tttgacttct 1780501 tttacgattc cgcttctatc tgcaacgatc gggatttcca ttttcatcga ttccaaaatg 1780561 gctacctcct ggcccttttc gatttggtcg ccggctttga cgtggacttt ccacaggttt 1780621 cctgccattt gtatgctaac cgtcatgaca actgcctcct ttataggtgc tgtttcaaaa 1780681 agtcagtcgt gacatcccct tctttaaatg cctttgttgc cgcagcctgt atgaggagcg 1780741 gaaggtttgt tttgattccc tctacacgat agtcgcgaag cgctgtctct agtttttcaa 1780801 ttgcttctgt tctggtttgg cctttgacaa tcatcttagc gatcatcggg tcataaaaag 1780861 gggtaacggt gctgtctttt gctaccgcac attcgtgtct gactcctttt tggtcaggaa 1780921 gtgaaaacgc agtgatcgta cctggtgacg ggaagaaggt cttgggatct tccgcgtata 1780981 ttcgaacctc tatcgcatgc ccgttccgtt ggatgtcttt ttgggagaat gtgagtgtat 1781041 ggcccgcagc aatccgcagc tgctgctcaa ctaagtccag gcctgttatt tcttcagtca 1781101 cggggtgttc aacttgcagt ctcgtattca tttcgaggaa ataaaaattt tgtttctggt 1781161 caactataaa ttcgatggtg cctgcgttcg tatagccgat tgccttcgct gcttttaccg 1781221 ctgtttgacc gatcttcatt cttagttcat cgtctacaaa tggagacggt gcttcttcaa 1781281 tgactttttg gtggcgcctc tgaacagagc aatcacgttc aaacagatgt actgtatggc 1781341 cgtgttgatc ggccaaaagc tgaacctcga tgtggcgcgc atgttcaata actttttcta 1781401 tatacataga cccgtcaccg aaaaaatctg ctgcgcgctt tttgtttccc tcgtacgctt 1781461 tttttaatgc ttcttcattt tcaacacgct gcattccgat gccgcctccg cccgctgaag 1781521 ctttcagcat gacaggatag ccgatttgac ttgcggtgcg gcaggctgcc tctatatctc 1781581 cgagggattc agaaacgccc ggcaccacag ggacacctgc agcctccatt gcttttcgcg 1781641 cttcaatttt gctgcccatc tttgcgatga tatcagggga aggtccgata aacacgatgt 1781701 tttcttgctt gcagcgttca gcgaaccggc tgttttctga taacaatcca tatcccgggt 1781761 ggatcgcgtc ggcttttgct tttttcgccg tctttatgat tctctctata tttaaataac 1781821 tttcactgac tctcgattcc ccgatcaaat atgcctctgt agcggctttt gtatggggcg 1781881 cgtccttgtc tgcttctgaa taaacagcga ccgttttaat gccgagacgg ctgcatgttc 1781941 ggataattct cattgcaatt tcaccgcggt tggcgatcag tacttttgta aacatgattt 1782001 cacctcattg acttgatgat aagttgaaca tttcaatcgt tttttctcgc agtttatatt 1782061 tttgaatttt gcctgaggcc gtcatcggat agtcatccgt aaaaataaca taacgcggaa 1782121 ttttgtggcg ggcgattttc cctttgcaat aggctttaag ctcatcaggt gaaacgcttt 1782181 taccgtcttt cagtttaatc caggctgcag cttcctcccc gaatttggcg tcaggcacac 1782241 caaccacctg tacatctaaa acagcgggat gctggtataa aaattcttca atttcccgcg 1782301 gataaatgtt ctcgccgcct ctgatgagca tatcttttaa tcttccggtg atgcggcagt 1782361 acccgtcttc atccatgaca gcaagatctc cggtaaacag ccatccgtca tgattgattg 1782421 cttttctggt cgcatctttg tctttataat agcctttcat gacgtgatag ccacgggtgc 1782481 acagttctcc ctgcatgcct ctttgaactt cttgacatgt cccgggttct acaattttca 1782541 cctcagtatg tggcagggca cggccggttg tttcgactct tcttatgaag gaatcatttg 1782601 ctctcgtttg tgtaatgact ggcgaggctt cggtttgtcc ataggcgatc gtaatgtctt 1782661 tcatgcccat cctttcaatc acagctttca tcacttcact tggacaggga gagccggcca 1782721 tgattcctgt tcggagcgtc gatagatcat atgcatcaaa atccggatga tgcagctcgg 1782781 cgataaacat ggtaggcaca ccatggagca ctgtgcattt ctctttttct accgttttaa 1782841 ggacggtaac gggatcaaat tcttgcacgg gtatcatggc tgccccgacg gatacacatg 1782901 ccaaaacccc aaggacgcat ccaaagcagt gaaaaaacgg aacagggatg cacatgcggt 1782961 cttgagaggt taaagccata cattcagcga tattagcagc gttattgatg acattgaaat 1783021 gggtcagcat cacgcctttt ggaaaccctg tcgttcctga tgtgtattgc atattaatca 1783081 cattgtcttt atccaggctg ttcattctct cttcaagctc agcatctgtc actgttttcg 1783141 ccaatatctc tgtatcgtcc caatgataca tgccagacaa tcgtttattg ccaatataga 1783201 tcagcgtttt taaaaaggga tagcgttcag atttcagttg gccgggcttt gcttcttgca 1783261 gttctggaat taaactgttc acgatgtctg gataagaagt gcccctgtat gaatccatga 1783321 taataagcgc cgcggcatcc gattgcttta acaagtaatc aagctcatgt gcttgataat 1783381 tggtattgac ggtcacgagc acggctccga tcttcgcagt tgcgaactgg acggcaagcc 1783441 attcagagat attagaagcc catatggcga cgtggtctcc ttttccaatc cccatccgca 1783501 tgagaccttt agcggtttga cggcacagac tgtcaaattg agcgtacgta tagcggatat 1783561 ttcggtctgg atacacaaca gcatctcgat cgggatacgc atcagctgtt tgttccagca 1783621 gcctgccgat tgtggaatgg atgagttcag ccattcattg ttcctccttt cttaatgata 1783681 ggaaagcgtt tacattttta ttttaaaagc tgtctggcga tcacgagacg ctgaatttca 1783741 gatgtgcctt caccgatttc cattaatttt gcgtcccgca gcatccgttc caccccatac 1783801 tctttcatat agcctgaacc tccatggatt tgaatggctt gattgcaagc tcttgtcgcc 1783861 atttcagatg cgaatagctt ggcgtacgcc gcttctttgg tgaacgggcg gttatgatct 1783921 ttcagccagg cggcttttaa caccatttgc cgtgccagat caatttccat cgccatgtca 1783981 gcaagcttaa attgaatcgc ttgaaaggaa gaaatcggct gtccaaactg ctttcgctct 1784041 ttcgcatatg ccaatgatgc gtcaagggcc gcttgggcaa tgccgactgc aagagcagcg 1784101 atggagattc gaccaccatc cagcgtatat agaaactgtt taaacccttt tgttggatcg 1784161 ccaagtaagt tggccgcagg cactcttaca tcttcaagca agatttccgc tgtattcgaa 1784221 ccgcggacgc ccattttatc gtacgggctc gtaatcgtaa gtcctggtgt gtcagttggc 1784281 acgattaatg cggagatgat gttttttccg tctttgtttt tgcctgttac ggcggttaca 1784341 ataactgtgc gtgcgtagct tgcattagtg atccagcact tttcgccgtt gattacatac 1784401 tcgtcaccat ttgaaatcgc ttttgtttga gtgcctcctg catctgagcc ggcatttggc 1784461 tccgtcaggc cgaatgatcc gagtgctgtg cctgaagcca gcggcgtcaa atgcgtctgt 1784521 ttttgctctt ctgttccgaa gtagtaaaga gggcttgcgc ctagcgagac cgctgcagca 1784581 tagcttaatc cagtactgcc gcaggctttg ccgacttctt caaccgctaa ggcatatgaa 1784641 atcgtatcac cgccagatcc gccgtattct tctggaaatg gaatacccat cagaccgagt 1784701 tcacccattt ttttaaatgt ttgcatcggg aactcgcctg tttgatctac atgttcagcg 1784761 tgaggagcaa tttctttttt cgcaaaatct tttaccattt cacgcaccat ttgttgttct 1784821 tttgtcagct caaaattcac atcgtttcct ccttcacatc tttgtaacat cctattaggc 1784881 gagttctata atcattccct gacaagaaaa gtctgaaaat taaaactgaa tcatttttta 1784941 tgtgataata tcagcgggat gagcaaatac atgcagtagg cgcataccat ccatatcgta 1785001 aacgcaataa cttggccctt tgataaagcc gggaagatga ggggaagatt ccaaagggaa 1785061 atcgtatcca tcaataaacc gaccgctgat ccccatatac ctagcttgat caccgcgaac 1785121 tgtgattgat cgagtttttg atagagaaag aacacaaggc ataaaacaag agcagtgccc 1785181 gctcccaaga gaagaaagtt cggcaaaaag gcttcttcag ccggatcagt caacacagca 1785241 tctccgaaca gcacaaaaaa taatgtggca cctaaccaga ctagaaatga aaacgtaaaa 1785301 cacgtcctgt acgtgtttct cttcgatttt atttttattt agtactagtt tctcagattc 1785361 caataatggt aaatgtccaa acaccgcctc catattcatg tgaatctcac ctttgttttt 1785421 taaaaaattc agcggtttac catcgtttcc tgtcccaaaa tcacttttta aaaaaagacg 1785481 acttagaaag ccgtccttct catttcttat tttgttgttc gtttggaagc tttgctttcg 1785541 ttatgaagcc ggtctgctga agtgacataa tacgtatatt tcttgttggg atctgccgtg 1785601 ttatctaaga aggtttgctg ctcatgtgtt tttctttgcg ttgccagcaa tgttctctgc 1785661 tttttccctt cggctctgta tatcgcataa taggctgttt ctttcgtttt ttgatttgat 1785721 gggtgatctt taatctgcag aagattgccg tttttgtctt cggtgacttt cgtaagcttc 1785781 ggtttttttg gggcggtatt gtcaagccaa ggcatttgcg gaaccagtgc cggcttgctg 1785841 taaagatcgg tgctgagact gtctttgatg ccaagcggat ttttgttgag gtccttgagg 1785901 ctgaaatgca tgcttccttt caccagttca agctggcggt tcaaagtgat ttgccgcaca 1785961 tattcctcag gatcggacca aggcggatca aaattgttat tgattttata tgctgcctgg 1786021 ccaatatata agtgaacagg cctatttttg acttcattgc tccaccaatc agccagcacg 1786081 tcgtaagccg ctgcgttaaa gccgatactc caataaattt gcggagcaat ataatcgatg 1786141 tcgccttctt ggatccaatg ccttgtgtct gcatatagat cgtcataatt tctgacgcct 1786201 gcttttgtat tcgatccggt cgggtcatct gcggcgtttc tccatactcc aaagggactg 1786261 atgccgaatt tgacatacgg ttttgcagct ttaattgttt ggttgatttg tttgacaagc 1786321 tggttcacat tgtcccgccg ccagtcatcg atattagaaa aagcgtcttt tccgtattgt 1786381 tcgtactgtg cttgatcagg aaattcctgt cccgctattt tataagggta aaaataatca 1786441 tccatatgaa cagcatcgat atcataatgt tttacgactt cttcaatgcc tttgacgata 1786501 aaatctctcg cttctggaat gcctggatga taatacagct ggtttccata ggcggcaacc 1786561 caatctggat gttttcttgc cgggtgatcc tcagacaatt tattaagatc tgtatgattc 1786621 attgtaatac ggtaaggatt aaaccacgcg tgaaattcca aatttcgttt atgggtttct 1786681 tcaatcataa atgcaagagg atcatagccg gggtccttcc cttggacacc ggttaagtat 1786741 tccgaccaag gcccgtaagc tgacggataa aaggcatcag ccgtcggttt aatctgaacg 1786801 ataacggcat tcattcccat tttttgcaca tcgtccagca gtttgatata ctcctgtttt 1786861 tgctctttca cagataaccc ttttttggac ggccaatcaa tatttaatac ggaagcaatc 1786921 catacggctc tcagctccct gtcagactgc gcattggcca taaacggaac ggaaatgaca 1786981 aacgttccga tgatcaagct gacaaggaaa cggacaatcg acttttggca aaccttcatt 1787041 ctgtttcttc tcccccatta catcactttc actattcgct attacggtat tcccgggcta 1787101 taaaagggtg attaacagaa tgtctatctc actaaataaa cgaaaaaagt cctaaagcat 1787161 gttgtgaacc gcttttagga ctttttatca ttcatcatgg tttgcagact ttttaacaca 1787221 tcaataagtt ttacgccgac accgacagcc gtttcaagga tcgcttgtgc tccggcaatg 1787281 gctaaaataa agatcagcgg tattgcaata cgaggcaaaa aaagatagcc aagtccgatc 1787341 aagatggcac accaaacacc ggcacaccag tagcaattga gcatgtatcc aaagttagaa 1787401 gccggcacgc ttttttcatc tacatgcccg ttttgatcaa caatcctttt ctttttcata 1787461 aaaggttttc ggataaattc tgtgattttg tcaaatacaa tcaaatgtgt cagcctgtaa 1787521 ctggctagaa tcagcatgat aaaagttaga aaagaaagac ggtccattga gaagcctcca 1787581 agaaaaagga tgatgttatc attcccaagt gtcccttatc cattcttgat acaaaaagaa 1787641 agacggacag agaatggcct ctgtccgcta atccgcttta tcgtttgtgc agtattactt 1787701 gatttgaagt gatcttttct aaaatgtcga ggatgatgtc ggcattcttt tcagcatatg 1787761 ttccttccag catgtcttta tgagcgccaa aacccgtgta ctcactatag tttccgcagg 1787821 cgccttccca tttcgttaag cctgtatgcc cgctggtttc ggggtggatt ccagcttcga 1787881 tgaaatgaat gcttgctttg atgtggcctt cattcagcaa ttgtgcccaa tattcctgat 1787941 agtttctttt tttcttcatc accttttctc tgactgcttc aggcagatat gctgcagatt 1788001 cgtcattacc ggtatcgata ggcaaaggct gttcttttag ataagcgtcc acgataatga 1788061 agtcgctgac ttctaatcct ttgcgctcca tagcctgtgc cacttcaaaa gccaggtttc 1788121 cgcctgcaga gtagcctaat aaaacgtatg ggccctcagg ctgtatgtcc gtcatgcaat 1788181 taacatattg ttcaatgcgg gtgtcttgtt caataaagtg aaacccgtat acggctgcct 1788241 tctcattcag caataaagca aggtctttaa aataaatgcc aaatcccgat atcggcggga 1788301 agcagaaaag attttgcgcg ccgtgctggt tcagtttgat cacatgctgt tcatttgctg 1788361 ctgtcagctg tttagaataa agtttttcgg caagctgagc gattgtcgga tgttcgaaca 1788421 agaaatcaat cggtatgtca atgttctgct gatgttttag tgtatgtatg acttgcagtg 1788481 ctcttagtga atgtccgcca atagcaaaga agtcatcatc aatactgatt gtgttaacac 1788541 cgaggacttg cttccaaatg ttcgccaatt cttcttcaac caagtttctt ggcaatatga 1788601 tgttctgtcg tttggcaggc ttattttctg gaataggcag cgcgctgcgg tctatttttc 1788661 cgtttccggt aagcggcatc cgctccacac gcacccagtg ctgcgggatc atatagtctg 1788721 gaagcacacg cgccaaatcg gcgcgaaaat ccgtatctgt ttttttgtga tcaccgacgt 1788781 aatgagtgta cagctgcgcc tctccatctt tttctctcaa tgtcactgct gcttcttgaa 1788841 cgccttccat ttctaacagg cgcgcttcta tttcggcagg ctcaattcgt tttccgcgga 1788901 ttttcatttg cctgtcaatt ctgctgatgt attctaagtt tccatcaggc agccagcgcg 1788961 ccaaatcacc agtacggtat attctttctc caggcaagaa aggatgagga gaaaacacag 1789021 catttgtcag atctactctg ttcaaatagc ctttagcgac tccatcaccg ccaacacaaa 1789081 gctcgccggg aacgcctatt ggcaaaagac gtccttttgt atctaagatg taagcggtgc 1789141 tattactgat tggttttcca atcggaatcg gccccgcata gtctctcttc atttcaaaaa 1789201 aggttgaaaa agtcgtgttt tccgttggcc cgtaaatatt atgaagcgcg agatctggac 1789261 aggcgtgtct gacggcattc atcagggcag gagagagtgc ttctcctccg acatataacg 1789321 tatggagtcc gcgaaacatg tcagctcgta cctgtgccag ctgattaaaa agagctgtcg 1789381 ttaaaaatag cactgtaatg tcattttcaa gcaaatacgc tccaaaccga tcaggtgtca 1789441 gcattgtcga tttatcaatg atatgaaggc ttgcgccatt taaaagtgcc ccgaacattt 1789501 caaaggtgac ggcgtcaaag ctgatagatc cagtcataat aaaccggtca tcaccggacg 1789561 cagacgtgta attgctgttt ctgacaaggg acacgacatt gcgattcgtg atcatgaccc 1789621 ctttcggccg gcctgttgat cctgaggtat acatgatgta cgcaagatca tccgggctgg 1789681 agctgatatt aatagggata tcgttctctt ccatcaatcc ctgcgcatct gaaatgatac 1789741 atgttcctga gaacgcagcg ttttgctcca atcccttttg aacaatcagc atttttgcct 1789801 gcgtttcctc aagcataaag ctgactcgtt caggcggaag ctccgcatca agcgggaggt 1789861 atgctccccc tgcttttaat acggcaagca cactgatcat gaattcggga gaatgtgcag 1789921 ccaatattcc ggctgtctcg tttttccgaa atcccttttg aattaactct ctggcgagcg 1789981 cattagagcg tttatcaagc tctttatacg aaatagacat attgccatac acaagtgcgg 1790041 tatggtctgg cgtcttttct gcttgttcgc gaaataaatc gataattgta tgattctttg 1790101 gatactccgt ttttgtattg ttgaactgtg tgacaatctg ctctttttct gttgcatcaa 1790161 gaaaagaaaa atcagcaatt ggcatatgag ggtgctgtgc agctgtgcta agcgcttgcg 1790221 taaattgcct cttgatacag ctgatccagg cagcatcgta aacgaatgca ttatagctga 1790281 acttgatgac aagctcttcg ccaggagcaa cgacaagatt aaagttatat cctgattgct 1790341 cggatacttg aacttgatcg atttgcagcg gtgaatcggt ttgatcagcg gaatcggcga 1790401 ttttctgctg taacggatag ttttcaaaga cgataatgtg atcaatcagt tcctgtttta 1790461 atgcggtgtt tgcctgaata tcaaataaag gctggcaggt aaacggctca gcttccagca 1790521 tttctttctg gcagcgtatg agcagctcgt gaaacgtttc gtcttggtgt gttttaattc 1790581 gaatcggtat ggtattgata aacaacccta tcatttgctc cacgcctggg atttctgacg 1790641 gtcttcctga tacaactgcg ccaaacacaa cgtcgtctgt gcggttatat tgctgcagca 1790701 tcacacccca gactgcctga ataagggtag cgagcgtgac gccgtgttgt ttggcagtct 1790761 ctttcagctt gtctgtcagt ggtttattta atgaaaatat caaatcttca cggtgataac 1790821 tttcttttgt ttctttatca gacacacgag gcagaggtga tggagcgctg tagtttttta 1790881 aataggtatc ccagtaggcc gctgcttttt ctttgtctcg gtttgtcagc catgaaatat 1790941 aggtgctgta cggacggaca gggtctaatg aaagcggttt tcctgcatga atcgattgat 1791001 aaatttgcat aaattcctgc ataacgatac ctaggcacca tccgtccatt aaaatgtgat 1791061 ggtgactcca gatacagaca tgctcatctt tagctgtttt gaatagagaa atccgcatca 1791121 gcatgtcttt ttgcagatca aagccttttt gcttgtcctt ctctttaaag cgttcaatat 1791181 actcattctg gtcgtttgtc ggcagatgag aaatgtcttc gctgttcaaa tggaattcac 1791241 gttctgtcat cacgacttgc cgaggtcccg acaaatgcgg gacgtgcggc aaaaacacgg 1791301 ttctgaaaat atcatggcgg tcgataatgg cttgaatgct gcgctggaac cagtcatagc 1791361 tgaggcttcc tttaatggtg aagagcgact gctcaacata cgccccctcc tctttacgga 1791421 ggaaggaatg aaacagcatc ccttcctgca tatgactcag aggataaatg ttcttgattt 1791481 ttttaatggt attcatagtg tctgcacctt tcttcacgga ttcattagtg aaaactgagc 1791541 atatcagcga tctcttgcag ggcgtcctcg gtcagttctt gatcatcaaa atcactgatc 1791601 gtcttttctg tttcgctttt gttctggcag tgttcgatca gctgtaataa aaattgacgg 1791661 catgtttcgc taagctgttc gatggttttg cgctgaaagc gggcattgtc ataagtcata 1791721 ttgacagtca attttccttc tgcagcgatt gcgctgatat ccagcgactg ttcacggttc 1791781 catgttgtgc tgatatcacc tccggcaccc agcggagaga atgagaaggc gtcctcctca 1791841 ggtacttcag ctgtgcggcc gctttcaaat tgaccaagat aattaaagct gatttctggt 1791901 gcacctgtga aattgatgtc ttttttgcca ggcggagtca aatatttgat gacaccgtag 1791961 ccgaatcctt tgtcaggtac acgtctcagt gtatcttttg ttgtttttag cacatgaacc 1792021 atgctttctt ccgaatctgg caagtctgcg ttcagtttaa tcaataacgg ataaatggcg 1792081 gtaaaccatc caatcgtccg gctcacatct attcctttta atacatcctc tcgcccgtgg 1792141 ccctctaatg atagtttgaa ggcggattga ttggtccaat ggcgcagcgc aagaatgaca 1792201 gaagcgagca gcatgtcctg cgtatcagtg ttatatgcgc tgttggcgtc ttttaagagt 1792261 gctgctgtct ctttatcgtt taaggtaaac gaaattgtgg accgttgtcc ctcgtgtgct 1792321 ctagttccat cgatttgatc aaaaggcaat gcctctgttt gatactcttc ggcttcgcgc 1792381 caatacttga gctgtttcat tagctgctgg ctttcagcgt agtcagagag ctttttcgca 1792441 tacgctttaa acgagcttgt tttaggcggc agtttgatat cctccccgcc agcagcttgg 1792501 cgatacccta aagccaaatc ttcaagcaga acccgccatg agatgccgtc aacgacgagg 1792561 tgatgagcag ataaaaataa gaaatcaccg tcaattgtgt ggaaaagacc ggcttgcagc 1792621 agcggaccat tcttcaaatc cattttctgc tgaatatcaa gtacatggcg cttgataaga 1792681 ggttcatacg gtctatttcc atcagtgccg tccggagctg acaaatcaat catctgaagg 1792741 ccgtacaacg cgtcgtccga atgactgagc ggccgattat attgatccca ctttccttgt 1792801 tcattctgtg taaacaccat tcgcagcgca tcatgatgac acgttattgc ttttaacgtt 1792861 tttcgcagtg cgtcttcttg tacagaggtg cttcgatgca gcattacgga ctgattaaaa 1792921 tggtgttttt cttttatatc ttgagaaaga aaccattttt gaacaggcga ccattgtacg 1792981 tctccctcaa ccgcagcttg gctggaactt gtatctgaat cacggatata agctgccaat 1793041 tcttgaatgg tcggatggct aaacaaatct ttcactgcca tttgcttgcc tatccggtga 1793101 agccgcgcag atacctgtaa cgctttgatt gaatctccgc caagttcaaa gaacgaatca 1793161 gctgttccga tcttttctgc ccccagtact tctttccata tatctgccag tatttgttcc 1793221 attttgctgg atggcgggag gaatggacgt tcaccttcgt ggttgtatac aggttttgga 1793281 agtgctccgc gatccagctt gccgtttggt gacaatggaa gtgagtccag tttttcaata 1793341 aacgcagggt gcataaacac cggcagcttg ttttgtaatt ctgagcgtac agcatttgtg 1793401 ctcaaccctg gttttgtcac cacataagcg cttaattcgg tttgtcctga cgctgttaca 1793461 tgagcaacta ctgcggcgtc ttttacaccc tttatacacc ggatgaccga ttcaatttct 1793521 ttcgtttcta cacggtatcc tctgattttg acttgatcat cgattcttcc gagatattcg 1793581 agtgtaccgt cggccatcca tctggcggcg tctcctgttc ggtacattcg tgcttcgggt 1793641 ttaaatggat tctgcgtgaa tgctctctct gtcagttctg gaagattaac gtaccctctt 1793701 gcaagccctg ttcctgctat acaaagctct cccgcaacac cgattggctg aagctgatga 1793761 ttgctattta aaatcagcac ttgagttccg tcaatcggct ggccgatgct tacgtatgcc 1793821 tgcttttcca tatgtctcat gacggtagtc gccacgctgt tttctgtcgg tccatattcg 1793881 ttggcgagtt cggtatgcgg acatatagct aagctgcggg cgatcaattc gcggtcagcc 1793941 gcttctcccg ccagtgtgac gactctaagc gtctttacat cttccggctg cactacgtcc 1794001 aaaagcgctc gatataaaac aggcacaata atcatatgtg taatccgttg acgagacagc 1794061 tgatgcttaa tggccagaat atccttcgct tcctcttcat gaagcaaaac ggcttttgca 1794121 cctgacaaaa gcggtgtaaa catactagtt ataaagccgt caaatgagaa agaaaagagc 1794181 tgcagaatgg tatctgtctc gttgaatgca taagcgtttc gccgccactg aagagtgtta 1794241 gcaatccctt tatgctcgac cattacccct tttggacggc ccgtcgttcc tgaagtataa 1794301 atgatataag ccaaatgatg ggcagacgac atttgcggca gcggcgattt gtcgtcttcc 1794361 tctacgcttt ctatcgtcaa gatctctcct tcaaagtcag caagtactcc cagatccgct 1794421 tcatttattg tcatcagcag tttcgttccg ctgtcgctga ggatatagcg tttccgttct 1794481 ttcgggtatt caggatcaat gggaacgtaa cagcctccgg ctttccacac accaagtatg 1794541 gatgctatca tactgaacga acgatgcatc atgatgccta ctggtgtgtc cggcttaaca 1794601 cctcggctgc gcaatgcacg tgcgattcca ttggaccact cgtcaagctc ctgataagtg 1794661 agtgttttgt ctccgctgac aagtgcagaa gcttttggtg ttcgtgcagc ttgctgctca 1794721 aacaattgac tgattgtttg aactccgtat tgattcgctt gcccggtgtt aaactcatta 1794781 agcagctggt gccgctcttc ttgggtcagg atgtcgatat ggttgagtgt caccttcggg 1794841 tttttgccga tgatgctaag tacatttgtt aaatgcgatg cccagcgttc aatggtggtt 1794901 ttctcgaaca atgcggttga atattcaaaa aggaaatgaa tgtttccgtc gccctcagat 1794961 gcctgtagtg tcaaatcgaa tttagaaacg agatgagaaa cttgtgccgg cttcatttgc 1795021 aaatcatgaa gatgcaatgg ctcgtaatca ttattttgaa caactaacat cgcatcaaac 1795081 actgggttcc ggctcatatc tcgtgtcaat tcaagcttat cgacaagctc ttcgaacggg 1795141 taattctggt gctcaaaggc ttccaatgct gtctcacgca cttcctgcaa atactgtacg 1795201 aatggcttcc cgccctccgg gcgcgtccga agcgccagcg tgttcacaaa catgccgagt 1795261 atcggctcaa gatccttgtg cggccggccg gcgattggcg agccgacgat gatatcttcc 1795321 tgtccgctta agcgtgacaa gaacgcggtg taagccgcaa ggagcaccat gtacagtgtg 1795381 cttccgtttt ctcgtgccag cttgtgaagg cctgatgcaa cctctggttc cagcgtaaat 1795441 gagaccttgt cacccgcgaa gcttcgcacc ggcgggcggg catgatcagc ggggagatcc 1795501 agcacaggca gctcgccctc gagctgcttc agccagtacg cctcctgcat tttgtacgcg 1795561 tctcctgttt tgaatccttc ttgccatacg gcataatctt tatattgaat gcgcagcgcc 1795621 ggaagcttcc gattattgta cagctcgccg aattcttgaa tcagaatgtt gacggaaaca 1795681 ccgtctgaaa tgatgtgatg catatcaacc agcaataggt gccgctcatc tgataccttt 1795741 acgatttggg cacggaacag cggcgcttgg ctgagatcaa acggtttgat aaatgcggct 1795801 gcggcctcct gttcggttcg tgcgccgaga actgtagtct gtaacgtaaa cggcacctcg 1795861 tcatggatgc gctgcaccgg atcgcctcct tcgtcctgtt cgaaggaggt tcgaagcgac 1795921 tcgtggcgct tgatcagctc ttggaaagct ctgtccatcc tttcagggtt gagcttccct 1795981 tcgagctcta acacagccgg catattgtag cctgtccctc cgtcctccag ctgctgaagg 1796041 acataaatcc gcttttgggc agaggaaacc ggataggttt cctgtttttc agcgggctta 1796101 atcgcttcat atggactgtc cgttccttca cggataacgg tagccagtcc ttctaccgtc 1796161 ggatgggcaa acacatcttt tagcggcacc tgtacatcga attctttggt gatccgtgag 1796221 acaagcgccg ttgcttttaa ggaatgtccc ccgcggtcaa aaaagttgtc gtgaatcccg 1796281 acagggccat ttttcagcac gtcctcccac agctgagaaa gcttcatctc agtcacgttt 1796341 ctcggcgctg tgtaggtctc cgcatctgcc gctccgccag gagctggcag ggcgtttcgg 1796401 tcgagctttc cgcttggcgt aaccggccac tgttccatct ctatcatata ggctgggacc 1796461 atgtagcccg gcaacagtct ctcaagctgc gctcggactt cgtttctttg gagcccttct 1796521 acataagcgc ataattccgg ctccccgctg tctgtccgta cggtaacggc cgcctctctt 1796581 acaccttcta tacttcttag tgccgcttca atttctcccg gctcaatccg gtagccgcgg 1796641 attttcacct gatcatccgt gcgcccgagg aattcaacat tcccgtcagg gagccagcgc 1796701 gccacatccc cggttttgta catgcgttca cccgggtaaa acgggtcttc aagaaaacgc 1796761 tcctccgtta atgccggccg attcaaataa cctctggcaa cacccgctcc ggctatgtac 1796821 agttcgccga tacatccaac aggcagcatc cgctgattct gattcaggag atataatctg 1796881 acatgatgaa caggttttcc aattgggatc cgttcaagtt tttcatgcgg cggacaatca 1796941 aagaatgcag cttctacggt tgcttccgtt ggcccatagg aattggttat tgaaacattt 1797001 ggaagcaact cgtaaaatcg ggagacaaga tgggtcccca gctgttctcc cccagaaaac 1797061 actcgcttga gtctgtttgt cttaatcggt acagagcgat attttatatg ttctaaaaat 1797121 gcatggagca ttgaaggcac aaaatgcata gctgtgatct tttgttcttc tatggccttc 1797181 gcgatcactt caggttcttt ttcgcctccc tgaggaagca gataaacaga agctccggca 1797241 taaggccacc aaaacagctc ccatattgaa gcatcgaatg aatatgatgt tttgtgcata 1797301 atcatatctg aatgctttag ctgatagcgg gactgtaggg aattcaaaaa attcaccgct 1797361 gatcgatgtt caatttcaac acccttaggc atcccggtag agccggatgt atagatgaca 1797421 taggctaaag attgcgggag aacatccaca ttcggattgg acaaacgatg tgccagtccg 1797481 ctatttgtct gattgagata gacaatctct cctgtaaatt ccggaacatg aaggccggca 1797541 gactgaagca ggagaatgtt tgtaccgctg tcctccagca gaaagctgat tcgttcttcc 1797601 ggataatccg ggtcgatggg cagataagcg ccgccagctt taagaatgcc ataaatgcca 1797661 agcagcattt caggtgaacg ctttcctata atggcaacag tcgtttcggg ttttaccccc 1797721 cgtccgatca gctcccaggc gatacggtta gcctgttcgt tcaattcttt ataggtcatc 1797781 actccatctt cgaagataac ggccgcctga tcaggcgttt tttctgcctg ctgttcgagt 1797841 gcatagtgga gcgtttgatt cattgaatag cccgtctcct caaacagatg gcatgattca 1797901 atgaaatctc gctcttcttc ttttgttaag attggaatat tgtccaattc tgtttcagga 1797961 ctggcagctg tatgttccac aagcgtggtg aaaaggctgg cccacctttg gatggtttct 1798021 ttctcaaaca aagctgtact gtattcaaac tgacagaaaa gctcggaatc atgctctgta 1798081 acgtataggg aaatatcaaa ttttgatatt gggtgctcca agtcgttcca ctgaagctgt 1798141 acatcattca tttttagctt ttgctgttcc atattctgaa ggactagcgt tgtgtcaaac 1798201 aaaggattcc ggctcatttc ccgctgcaca ccgagtttgt ccacaagctc ttcaaacggg 1798261 taatcctgat gctcatacgc ttctagtgcc gtctgtctga cttctttcag aaattcctca 1798321 aatgtcttat tacccgccgg gcgtgtgcgg agagccaatg tattgacgaa catcccaaga 1798381 acagcttcaa ggtcggcatg gggccgtccg gcgataggtg aaccaatcac gatatcatcc 1798441 tgaccgctta accgagacaa aaaggctgaa tacaaagcga gaagcgtcat ataaagcgtg 1798501 cttctgtttt tatgggcgag ccgctttatg cgggccgtga tctctttgtc caattgaaag 1798561 gttacttttc cgcctatgaa ttgccgttct gccggacgtc gtttatctgt tggaagctcc 1798621 agtataggaa ggtccccgct aaactgctgc tgccagtaag tctcctgctt ttggtacgag 1798681 tctccctttt taaatttctg ctgccatacg gcgtaatctt tatattggat ccgcaatggc 1798741 ttaagctgcc ggtttgcata aagatcggta aattctcgga ttaggagctg aacggatacg 1798801 ccatctgaaa tgatatggtg catatccacc agcaatacat gcttctcgtt tgacacttct 1798861 ataaggcctg ctctaaataa tggcgcctgg ctgagatcaa agggacggac aaatccctcg 1798921 atagtggtct ctttacttaa cgtaaacggc acttcggtgt ggatacgctg aaccggctcg 1798981 tcatcagctc cggatacaaa ggaagttcga agcggctcat gccggctgat cagttcttta 1799041 catacagcag acagtttggc gacatccagt gcaccttcca gttctaagac cgcaggcatg 1799101 ttataggcga caccctcatc aagctgttga agcacataga ttcgtttttg ggccgaagat 1799161 acaggatatg tatccctttt ttctgctggt tcaattgctg catacagatt ttgttctgcc 1799221 tctcgaataa ttaaagctaa tccttcaaca gtcggatgag caaagatgtc cttaagtgaa 1799281 acttgcacat ggaattcctt tgcgatccgt gacataagca ctgttgcttt taacgagtga 1799341 ccgccattgt caaaaaagtt gtcttggatg cctatatgcc cattctttag cacatcttca 1799401 aatagttgcg aaagctttgc ctctaacaga tttcgagggg cagtatatgg gtttccgctg 1799461 attgaagcat ctggctccgg aagtgctgcg cgatctactt ttccgtttgg ggtaagaggt 1799521 atgctgtcaa cccatatcca tttcgccgga atcatgtatt ctgggagctc actagccata 1799581 taactgcgta aatctattgt gttcagcttt tgtacactgc aatagtaagc gcataattca 1799641 tgttcaccgt tttgatcttg ccagatgaga atggcagcct cactaatgtc cggatgattc 1799701 attagcgtga cttcgatttc ttgcggctca attcgataac ctctgatttt cacttgattg 1799761 tctgcccgtc cgatatattc gatgttgccg tcttcaagcc gtctggccaa atcacctgtc 1799821 cggtacatga tcacatcagg cttgaatgga tcggatgaaa atttgtcgct tgtcagttta 1799881 tcgtgattga catatcctct ggcaacactt gcgccggaaa tatagagttc gcctggtacg 1799941 ccgcatggct gaagctgttt ttgatgattc aaaatatata gatcagtaca gcctatcggt 1800001 ttaccgattg gcggaagctc aggaataggg tctccaggat gaatggtata cgtagatacc 1800061 acatgagttt ctgaaggtcc gtaatgattg tgcaggtgta tgccgcgttt acgcaacaca 1800121 tcttggaaaa ggtctgaaat cattaattgt tccccggctg cgatcaggtg tttgacgcca 1800181 tcaggaaacg agttcgcaag ttctcgctcg ctgaaaatca ttttgataaa agcagttggg 1800241 agaaacacaa tattcgtctg atgcttgttt ataaatgcaa acagctgagg cacatctctt 1800301 tttatggctt ctggcacgat gtggagtgtg ccgcctttca gaagcgcaga aaatatttct 1800361 tgatagcaga cgtcgaagga aggcgtcgca aattgcagaa catctgcttc aaagtcaatg 1800421 ccggagtgag tatattcgaa cttcagcaag ttagccatgt ttcgatgctc aaattgaaca 1800481 ccctttggtt tacctgttgt gcctgatgta taaatcatat acagcagatc gtcagcattg 1800541 ttgactgact ttatgttact gccgtctact ttgctttcga tatcttctgg atgagtgata 1800601 atgtaattgt cttctaacga tgagggaaga tgcgcttgtg aaacaacatg cgaacagccg 1800661 caatcatgca gaatataacg gattctgtca gcagggtaat gcggatcaac cggaacaatg 1800721 gcgccgcctg ctttcaagat accaagaaca cctgtgataa acgccgctga gcgttccatc 1800781 ataatcgcaa cgggttcctg tctcacaacg cctttcattc gtaaatgccg tgccaatctg 1800841 ttagccgctt tattcagttc tctgtatgtt aatgagcagg cttgatcaat tacagcatga 1800901 gcatctggtg tcttttccgc ttgcttttca aacatggcat ggatggtttc gtaaactggt 1800961 gtttgatctg tgatttctcc aatcagctgc cgcttttcag tatctgtcgt gatatcgatt 1801021 tcttcaggtg gaagattcgg attatttaag atttgtgata cagcattcag aagatgctct 1801081 ttgacagaga gcacaaaaga ccgatcgtgc tgctccgcat catagttcat tttgatatga 1801141 atttcttccc ctggcgccac cataagataa aagctgtagt tggtttcatc tgcgacagtg 1801201 aaattatgaa tctgaaaaag atcagaagca tgttcctgtt tgttcagcat ttgaatctct 1801261 tgctgcaccg gatagttttc aaatacgaga atatgatcaa tcagcccttg cttaacagct 1801321 gagcgggatt gaatctcata taaagggtgg tagctgtacg cttcagcggc aagacggtct 1801381 ttttgcatat cttttataag ttgaagaaaa ggcgtttttg ccccctgcac ccgaaccggc 1801441 atcgtattaa tgaaaagacc taccatatgt tcaatgcctt cgatttctgc gggtcttcct 1801501 gaaatgacag aaccgaatac ggcgtcatcg ttattattat atttttgcag cagaatgccc 1801561 caaatggtat gaaaaatcgt actgagtgtc acttcttctc tagcagcaag ctctgaaagc 1801621 ctgctgcttt cttccttaga gaatgaaaat gtaacgtgtt cctgcctgct ttttcccttt 1801681 gtttttttct gcttcgggag cacggtttgc tgttcgtggc cggaaagata atgatcccaa 1801741 taagaaaccg cctgctcttt gtcttgctcc atcagccatt tgatatactt tccgtatggc 1801801 tggaccggct ccaatgttat tggggatgca tttacataag atgcgtaaat atgcagaaac 1801861 tcctttagca caatgctgag gcaccaaccg tccatcatga tatgatgaaa ggtccaaatg 1801921 caagagtact ggctctctcc tgtttgaatc agagcgatgc gcatgagcac atccttttgc 1801981 aaatgaaacc cccggtcccg gtccttttct ttccattgct cgataaactg tgattgctcc 1802041 gcctcgttta aatgagtaat gtcttcttcc agtacgatga catttcgttc tctcagaaca 1802101 acctgctggg gggaggaaac attttggctg ataaaaatcg ttctgaaaat atcatgtctt 1802161 tctacaagag cgttgatgct gttttgaaaa aactgcgggt tgacttttcc ttctattgta 1802221 aaagaagctt gctcaacata cgcctgtgaa tctttttgca ggagggaatg gaaaagcatc 1802281 ccttcctgca tgtaagacag cggataaata tcctgaattg aattcgcttt tgtcatgttc 1802341 atgtctcctg tcacgatttt ctacaattct tccaccaagc tggatatgct gtccaagtcc 1802401 tctgccgtta atgattgact gctgaaatcg ctcagtgtct tttctgcttt ctgttgaccg 1802461 gcgcagtgtt tcataatgtc cagcaaaaag tgttcaatcc tgttaataag ctgttccatt 1802521 gtgtttctgt gaaagcgggc tggcggataa ctaagattga aatggagctt tttgtctgct 1802581 gccattgcac tcatctcgat gatttgctcg cgcttccatg tatgagtgat atcctttccg 1802641 ctaccaaggc ttgatgggcg gaaggtgtcc tgtctttcga tgtcgttgaa ctggcccaaa 1802701 tagttaaagc tgatttcagg tgtttttgaa aacgtaatgc ttttattttc agggtgtgta 1802761 aggtatttca gcataccgta acctacccct ttgtttggta tccggcccag tgtatcttta 1802821 acggttttta ctgaggttcc gagctcatcc ctatgatttt caaagcttat gagggccggg 1802881 tacatggatg taaaccagcc gaccgtcctg cttatatcta actctggcag aatgtgttct 1802941 ctcccgtgtc cttccatagc gatacggagc ttgcttcctc ctgtccattc acaaatcgcc 1803001 aaggatgctg cggttaacag aatatcttgt gtatctgtgc cataggcgtg attgacgttt 1803061 tgcagcaaga cggcggtgtc tgcttcagtc agtgaaaagc ttaatgagtc ccttttgctg 1803121 aagtcgatgt tcacatgatg cggtatttca tagggcagtt ctgcggcttg ctgttcttct 1803181 acacttcgcc aatacgcctc ttcgcgaatc agcttactgc tttgggcata ttcctgtatg 1803241 cgtcttgcgt attcctggta ggaatccgtt ttaggcggaa gctggatcgt ctggcctgca 1803301 gcagcttgtt gatatccggc tgacaaatcc tccagcaaaa tccgccatga gacaccatca 1803361 acgacaaggt gatggatcgc aaggaacaag taatctccgg tcagtgtttt aaacaaagcg 1803421 gcgtgcaaca atggtccttc ctgcaaattg atgctttgct gaagatcggc aacttcttgt 1803481 ttgattttcg tctcccagcc gctttctgac tgtgaaagat cagagattct taagctgtat 1803541 agctgtgact catgaatgcc ttggttgatt tgaatccatc gcctgtcatc gttgcgataa 1803601 accatccgaa gcgcatcatg atgctccgcc agttttttca aggctggtct aagggcgttt 1803661 tcagacaaac gtccagaatg gaatagcatg acagactgat tgaaatggtg tctttcttca 1803721 atatcttgtg aaaaaaacca ttgctgaaca ggcgtccaag gaacgtcacc ctgaatgggt 1803781 ccttgctcta tgattctctc tgacttacgg ataaatggtg ataagtcctt tatctttgga 1803841 tgacggaata aatcacttac ctgcaagctt agtccatagc gcccaaggcg tgcagaaact 1803901 tgaagggctt tgattgaatc tccgcccaat tcaaaaaacg aatcctctat tccgatcctc 1803961 tggatgccta gaacctcctg ccagatcaat gccagctgct cttcaagttc gttgcgtggc 1804021 gggatgtatg tttgtttaga tgcgacatct ggttcaggca gtgctttccg gttcaatttg 1804081 ccgtttgatg tgagcggaag agtctccatt tcaatgatat acgccgggat catatagttt 1804141 ggcagcgaac gcgcgagaag agaacgcact tgttcagcat tcgtgcctgc ttttacgctg 1804201 atatagccaa acagctcttt gctcccggtc tgggctgtac gtgctaacac tgcggcttct 1804261 ttgaccccgt ctatttgacg aagtgctgtt tcgatttcac ccagctccac ccgatagcct 1804321 ctgactttta cttgatcatc aatacggcca acgtactcaa ttgtgccatc ggaaagccag 1804381 cgcgccagat cacctgtgcg atacagtcga tcgccaggtg caaatggatg tgggacaaat 1804441 ttctctttcg ttaaatcagg acggcccaaa tatcctctgg cgacgccatc tccgccgaca 1804501 caaagttcac cgacagctcc gaccggctgc agcactcccc attgatttaa gataaaagcg 1804561 gtggaattac caaccggccg cccgatcgga atggaaagtt catatgtttt ttgaatgtga 1804621 aggcatgtcg aaaaagttgt attttcggta gggccatatc cattccatat agatacttca 1804681 gggcagacat ttctgattcg attgacgtgg ctcggcgaca aagcttctcc gccaataatc 1804741 aaatgtttca gctgtgaaaa tgtttgttca ttttgctctg tcaaatgatt gaatagagaa 1804801 gatgtcagcc aaatcgttgt gattccttga tgttctatgt acctcttaag ctgatgggaa 1804861 tcgagaaatg tttgttgatc ggacagatgc aaagcggcac catttagcag cggtccgaaa 1804921 atttcaaatg acccaacgtc gaaaccgatt gatgatgtca tcagaaggcg gtcttcaggt 1804981 gtaaatgtaa tataattgct gtttttaaca agacgaatta cacttcgctg ctcaatcatg 1805041 acaccctttg gtttaccggt tgatccagag gtataaatga tatatgcaag tgaatggggc 1805101 cctgctgaag attcaacgtt cttcgcctct ccttgctttt gaatatcttc gattatgatt 1805161 tgttcacatt caatgcctaa tagccgtttt tctgtttttt cagattgaag gagtaatgct 1805221 gccctgctgt cagacagcat ataagctatg cgttcaacag gcagattaga atcgataggc 1805281 agataggctc ccccggcttt tagaatgccc agcattcctg caatgagttc tggtgttctg 1805341 cctgtcaaca aggctacaac actatcaggc cctacgccct ttatctgtag aactgaggca 1805401 atttgatttg cccagctgtt caggtcctcg taagtgaata cttgggtgtc gctgacaatt 1805461 gctacagcat taggtgtttg ttctgcctgc atttcaaaga gtctgctgat ggtttcattt 1805521 cttggataat ctatttttgt acgattgagc tcgtggataa ggtaatgggc ctcatcctca 1805581 ttcaggatat ttattgttcc gagagcggct ttgttgtctt tgatgatgga gagtaacata 1805641 ttgttgaagt attgaagcca cttttctatc gtttttttct tatataagtc agtactaaac 1805701 tccatttgga acgtcagcaa accgcggggc tgttcctggg catatagggt taaatcaaat 1805761 ttggacgttt gatgcccatt gtttgctgca ggtttgagac aaagttcatc cagctccaac 1805821 gattcctgat ccatattttg aagaacaaac attacgtcaa acagcggatt tctgctcata 1805881 tctcgtgtca attcaagctt atcaacaagc tcttcgaacg ggtaatcttg gtgctcaaag 1805941 gcttccattg ctgtctcgcg cacttcctgc aagtactgta caaacggctt cccgccctcc 1806001 gggcgcgtcc gaagcgccag cgtgttcaca aacatgccga gtatcggctc aagatccttg 1806061 tgcggccggc cggcaattgg cgagccgacg atgatatctt cctgtccgct taagcgtgac 1806121 aagaacgcgg tgtaagctgc aaggagcacc atgtacagtg tgcttccgtt ttctcgtgcc 1806181 agcttgtaaa ggcctgatgt aacctcttga tccagcgtaa atgagacctt gtcacccgcg 1806241 aagcttcgca tcggcgggcg ggcatgatca gccggaagat ccagcacagg cagctcgccc 1806301 tcgagctgct tcagccagta cgccccctgc gttttgtacg cgtctcctgt tttgaatcct 1806361 tcttgccata cggcataatc tttatattga atgcgcagtg ccggaagctt ccgattattg 1806421 tacagttcgc cgaattcccg aatcagaatg ttgacggaaa caccgtctga aatgatgtga 1806481 tgcatatcaa ccagcaacag gtgccgctca tctgatacct ttacgatttg ggcacggaac 1806541 agcggcgctt ggctgagatc aaacggtttg ataaatgcgg ctgcggcctc ctcttcggtt 1806601 cgtgcgccga gaactgtagt ctgtaacgta aacggcacct cgtcatggat gcgctgcacc 1806661 gggtcgcctc ctgcgtcctg ttcgaaggcg gtccgaagcg actcgtggcg cttgatcagc 1806721 tctttgaaag ctctgtccat cctttcaagg ttgagcttcc cttcgagctc taacacagcc 1806781 ggcatattgt agcctgtccc tccgtcctcc agctgctgaa ggacataaat ccgcttttgg 1806841 gcagaggaaa ccggataggt ttcctgtttt tcagcgggct taatcgcttc atatggactg 1806901 tccgttcctt cacggataac ggtagccagt ccttctaccg tcggatgggc aaacacatct 1806961 tttagcggca cctgtacatc gaattctttg gcgatccgtg agacaagcgc cgttgctttt 1807021 aaggaatgtc ccccgcggtc aaaaaagttg tcgtgaatcc cgacagggcc atttttcagc 1807081 acgtcctccc acagctgaga aagcttcatc tcagtcacgt ttctcggcgc cgtgtaggtc 1807141 tccgcatctg ccgctccgcc aggagctggc agggcgtttc ggtcgagctt tccgcttggt 1807201 gtaaccggcc actgttccat ttctatcata taggctggga ccatgtagcc cggcaacagt 1807261 ctctgaagct gtgcacgcac ttcgtttctt tggagccctt ctacataagc gcataattcc 1807321 ggctcgccgc tgtctgtccg tacggtaacg gccgcctccc ttacgccttc tatgcttctt 1807381 agtgccgctt caatctctcc cggctcaatc cggtagccgc ggattttcac ctgatcatcc 1807441 gtgcgcccga ggaattcaac attcccgtca gggagccagc gcgccacatc cccggttttg 1807501 tacatgcgtt cccccaggta aaacgggtct tcaagaaaac gctcctccgt taatgccggc 1807561 cgattcaaat aacctctggc aacacccgct ccggcaatgt atagttcgcc ggcgacaccg 1807621 gaaggctgta cggctaaatg cggatctaaa acatacaaac gcgcaccagg tacgggcttc 1807681 ccaatcggaa tccgcaaacg gtctctgtcc cgttctggat ctaacacgta aaatgccgcg 1807741 tctaccgtgg cttctgtcgg cccgtagcca tggattaatg atacctgcgg caatacagaa 1807801 gcaaaacggg ctgccgtacg cggcgcaagc ggttcacctc cggcgaatac acgctttagg 1807861 cttgtcctgt cactcagcct ttcgatttcc gcttgatcga gaaagctgtt cagcatagcc 1807921 ggaataaaat gagccgttgt cacgttttcc tgatgaatgg cttgtacgat caatgcggag 1807981 tctttttccc agccgggcgg aagcagatac gccgaagcac cggaaagagc ccaccaaaac 1808041 agctgccaca cagacgcatc aaaggaaaaa gaggttttca ccatgacaat gtcatcttcc 1808101 gaaagccgaa actggtgctg catgccggtc agaaaggaaa cagcctggcg gtgctcaacg 1808161 gccactcctt tcggctgccc ggtagagccc gatgtataga tgacataggc gagagatccg 1808221 tcgctaacag aagcagacac atgacgtttt acttcttcac actcaagaga tgtcatgtcc 1808281 acttcaagcg tttcgccaga aaagtttggt gcggagcatc ccggctgtgt cagcaagagc 1808341 gatgccccgc tgtctttcag catgtagctc agccgctcct ttggatacgc aggatcaagc 1808401 ggcaaatacg cccctccggc cttcaataca gcaaggacag cgatcagcat gtcaggtgag 1808461 cgttcagaca ggacaccgac gatactttcg tttgtgacgc cgcgtgccgc aaggtgcgca 1808521 gccagccggc tggcgtacat atcaagctca gcgtatgtca gcgaaccgcc tgaaaagcga 1808581 atggccagcc gctccggtgt gactgccgcc tgtcgttcaa acagcccatg cagggttggg 1808641 gcttcaggtg aaacagatac tgtcctgtta ttttgagaaa cgattttccg tgttttgtcc 1808701 tcatctagca acgtcatctt tgacacagga agagatggat cagagatgac gtcagagacc 1808761 atgtgcagca aataatcttt tatttcggac atcatgcttg gttgataagc gctggtctga 1808821 aaatgaatcc gaacgtacaa ggtacggcct gggatcactt tgacactgca actataattg 1808881 gtcacctctt ccatctcaaa atctttgacg gagaaatcaa atgaccccgc ttgattcagc 1808941 tcttcgatct cttgctgggt aggtgtattt tcaaagacga taatatgatc gatcaactct 1809001 tgctttagag cactctgcgc ctgaatatca tacaagggaa agtaactata ggcttctgcc 1809061 tcattcatgt ccttttgcat tctcctgact aggtcagaaa aagacagaga atcactttgg 1809121 gctcgaatag gaatggtatt gataaaaagc ccgaccatgt tttccacatc ttttagctca 1809181 gaaggtctgc ctgatataac tgaaccgaac acagcatcgc tgctgcgatt gaccttttga 1809241 agcataatcc cccataaagc ttggaaaaca gtgtttagtg tcgcaccaga agctgctgcg 1809301 attttctgta attcggcggt ttctttttcg ggaatggcaa acgtgatctg ctgtagtgtc 1809361 ccattcggaa tttgatctgt tcttttcggc aggggtgtag atttttcgaa atgctgaagc 1809421 ctctttttcc agtactcagc tgcttcttca cgatcttgct gcatcagcca tttaatatac 1809481 gtcccgtacg gctgtacggg aggcaaatca ggaagctggc ctttacccag cgcttgataa 1809541 atatggagaa agtctttaat gacgatgcct aaacaccagc catccattaa aatatgatgg 1809601 tggctccaga tacagacata atgatcaggc gcccatttta aaatagatat tctcatcagt 1809661 acatccgttt ggagatcaaa gcctttggat ttgtcctgct ctttgaatgc ctcggtacaa 1809721 tgttctttat ccctttcatt gagatgggaa atatcttcaa tatgaatagg gcaatgacgt 1809781 tgcttgagca cgacttgacg aggtttggct acatttttat agatgaatgc tgttcgaaag 1809841 atatcgtacc tgtcaaaaac agcatccata cttttttgga aacgctccaa gtcaagctgt 1809901 ccatggatcg taaaagaagc ctgttcaaaa taagctctcg actgttcatc atacagtgag 1809961 tgaaaaagca tcccttcctg cataaatgac aaagggtata tatcctgtat ttcaggttgc 1810021 tgcggcatca gtgaatctcc tctcctatag tttgttgacg gctcccatga tctcactcaa 1810081 ttcatcaagc gttaagtctt catcagtgaa atcagatgcg ctccactctt ggttttcttt 1810141 gccggtacaa tgctcaatga tgttttccag agtctgttta aaatgcctgg aaaatgtttg 1810201 gattgttttt tcctcaaatt gaaacctgtt atagatgatg tgcatgttca ggcaccccga 1810261 agaaacggcg ccgctgatat ccagtgcata aggacgctcc cagttcgggc tgatctcatt 1810321 tcctggcttg atgtcagaca cctcaaaggc atttgattga atatcctgat caaactggcc 1810381 taaataatta aagctgattt ctgggctgtt tttctgagag ccccatcttt tgctgatata 1810441 tttcagcacg ccgtagcccg cgcctttatg cggtatacgg tgcagcatat cttttgtctg 1810501 tttaataagg tggcccagcc gctcttcttt gtccttatga tcggaatctc tcatatcaag 1810561 ccacacagga taaatggagg tgaaccagcc aacagttctg ctaatatcga tgtcctcaag 1810621 atatgattcc cttccatggc cctccatgct gattttaaat tggttatttc ccgtccattt 1810681 ctgcaaagca agacctaaag ctgtcagaag gatatcattc atctccgtgc tgtaagcttt 1810741 atgtgcagcc gttaatagta attctgtgtg atggcgagat agctcaaaat caatcacttc 1810801 tgtatctttg aatgtgttag atgctgcgtc attgtctttt ggaataggct ggatgtgacg 1810861 gttctcgcac tcatcccagt acgctgcttc gcgctgcacc tggcggctta tagagtagtc 1810921 agctattctt tgtgaatacg ttaaatatga atctgttttt tgcggcagtt taatagattc 1810981 tcctgagact gcctgtttgt aagctgttga aaaatcctca aacaaaatgc gccaagaaac 1811041 cgcatcaaca actaagtgat gaatcgttag aaataaatgg tcaccattct cggttctaaa 1811101 caatccagcg tgaagtaagg ggccggtttc caaacgaata tgttcttgca tccggctggc 1811161 tgcttcctca atcgtgttcc gggcttctgt taggctatcc tttacatcaa acagttcaag 1811221 tgcatatagc tcctcatctg aaagatctat ccctctgttt atctgcactt gcctgccatc 1811281 ttcatgccgg catacgattc tcagtgcatc atgatgagtc acaaggcttt ttagtacttt 1811341 tctaagcgca gcctcatcaa atcgttcagc ccggtagatc ataacggatt ggttaaaatg 1811401 atggctttcc agagattgcg agaaaaacca ctgctggata ggtgtccaag taatctcgcc 1811461 ttcgaccggg ccttggtcaa tggcgcgtac gtcttttcga acccgggcgg acagttcacc 1811521 aagagtctga tgttcaaaca tctcacgtac tgtcgtttca aatccgcgct gcttcagtct 1811581 ggcacaaacc tgcagcgctt taatagagtc tccgccaagc ttaaagaaat tggcgcttac 1811641 acccagctca tctacattaa gaagctcttc ccaaatttca gccatcaccg tttcaatctc 1811701 atttctagga ctgatatcat cagctgtata agcttgtttt tcaggctctg gcagggcttt 1811761 ctgatcgagc tttccattaa cagtcaccgg gatgctgtca atttgtatca tacgggcagg 1811821 cagcataaag tcaggcaagg cgttttttag gtaagttcgg atgtctgata tattcgcagc 1811881 ctgttgatct tttatcacca tatatgcata tatagctgtt tgcccttgct cgtctgctct 1811941 ggtaatgaca gccgcctctt taatcattgg atactgaaga agtgccgctt ggatttcgcc 1812001 taactcaata cggtgccctc tgactttcac ctgctcatca atgcggccta agtattccag 1812061 ctcgccattt gacaggcgct tagcaagatc tcctgttcgg tataatctgt ctcccggaag 1812121 ataaggattg gatacaaaac ggtcagcggt cagctcatct ctgttgagat atccccgtgc 1812181 cacaccttcg ccgcctatat acagctcccc tggaactccg gtcggctgca ggttcatatg 1812241 ggcatccatc acatgagcct gcagagtaga aagaggccgg ccgatattgc ttttattttt 1812301 tgcaatgtct gctgcggaca attttttgaa tgttacatgg accgttgttt ctgtaatacc 1812361 gtacatatta atcaaatcag tatgaggata tttttcattc cagctttgaa gcaatccggg 1812421 ctgtaaggct tcgccgccaa aaatcacata gcggatgttt aaatgatctg tatgattttg 1812481 gtcttcaagc atcaagccgt aaaaagcagt cggggtctga ttgagtacag tgacgcgctc 1812541 tttttttaac aataatcgga atgcttgggg gtcacgggct gtttctttag agaccacgac 1812601 taatgtactt ccgttcaata acgcaccgaa catctcccat acagagaaat caaagcaata 1812661 agaatgaaat aacgtccaga cgtcttcatg gttaaattca aaaggcaggt tttgatgctt 1812721 caagagactg atcacattgc ggtgctcgac aatgactccc tttggctgac cagtcgttcc 1812781 agatgtgtat atcacgtatg cgggctgatc cgttactatt tcttcaatgt ttacatcagc 1812841 cggaattgag ttgttttcac attcatcgat atacaaaata tgcccggtgt agtctgcagg 1812901 tttgtttaga ccgcgctctg tcagcagcag ttttgctccg ctgtcattga gcataaagct 1812961 aatacgctcc ttgggatatt caggatcaat cggcaaatag gccccgccag cttttaaaat 1813021 cgataaaacg ccaatgatca tatcaggtga ccgatcgagc atcagaccga cgatatcgcc 1813081 agttctgacc ccttgtttga tcagcatagc agctgcccgc tcggcttttt cattcaggtc 1813141 tcgatacgta agctgagaat ggccgcacac cactgcgata tgctccggat actgagctac 1813201 ttgcttttca aataagctta ctatgttttc atttctcgga taagctgcat actgccccat 1813261 tttttcaagg agtaacctac gctctgcagc aggaagcaat tgcatgttcg aaattctcat 1813321 ctcagtatcc gccgttaccc cttttaccaa ttcaataaaa taggatgccc actgcgtaat 1813381 ggtttcttct tcaaaaagag cagtgctgta ttcaaaacgg cagcgtattc cactcagatg 1813441 ctcctcagca tgtaatgtta aatcgaattt agatatatca tgtttaggag tgacagacga 1813501 aatcgacaga ccaggcactt cgaaccggaa atcttcactg ctttgaagca caagcatcgc 1813561 atcgaacagc gggttgcgat ttacctctcg atttgtatcg agcttatctg ccagctcctc 1813621 aaaaggataa tcctgatgct cgtaagcggt cagagccagg tggcgaatgt catgcaaata 1813681 ggagctgaac gttttgtggc cctcgggctt gctgcgcatc gccaatgtat tgacgaacat 1813741 tccgatgacg cgctccagat cagcgtgcgg tcttccggca gcaggcgaac cgacaacaat 1813801 atcctcttgc ccgcttagct tagataacaa aatagaatag acagccagaa gaatcatata 1813861 caatgttgtt cccgtttcag ccattaaacg gtgcagttca tcagccatgt ctttatcaat 1813921 gttgacttca attgttccac ccctgaaatc agggagacgc ggccttgttt tatcaagcgg 1813981 taattctagt gtaggaagac tcccgccaag ctgaccgagc cagtaggcct cctgtttttt 1814041 gtatagctct ttcgggtgct tctcttgctg ccaaacagca aaatccttat aatgcaggtt 1814101 taaagctggc aactcttttc cgcaatataa gtcagtaaat tcttggacaa gagtgctcat 1814161 cgagacaccg tcggcaataa tatggtgcat atcgagcagc aaaaagccgc gattattgcc 1814221 cattgtaatg acacatgctc taaaaagcgg accggatgat agataaaacg gtttgataaa 1814281 ggtctcgatt gcagactcaa gcatttgttc tgattccatt tcaagctctt ttagatcaaa 1814341 agccatctct ggataaatga tctgcacagg ctcgtctctg tcaagcacaa aaacagtccg 1814401 taatgcttca tgccgattca caagttctgt gagaacgctt ctcaaccgct ggcgattcag 1814461 atttccgcgt aattcaagta cagctggcat gttgtagcct gtgctgtcat ctgccagctg 1814521 atgaagagca tataatcgtt tttgcgagaa agacagcgga tagacatctc tttgatccgc 1814581 aggttcaatc tgtgtaaaag cgtgttcttt taagctcatc aatttgaccg ccatgctttc 1814641 aaccgtcgga taagaaaaca cctcactgag cggcagctcg acattaagct ttttatgtat 1814701 tcttgatacc agtgcggccg cttttaagga ctgtccgcct aactgaaaga aatcatcacg 1814761 aatgccgatg tgctgtttat tcagcacatc ttcccaaata tgtgcgagat cagcttcgat 1814821 taaggttcgg ggcgccatat atgtgacact cgtattgttt tctggttcag gaagcgcaaa 1814881 cctgtcaagc ttgccgctgg atgttaatgg catctggctg atgttgataa tacttgctgg 1814941 gatcatatag gacggcaatg tcccggcaag atgctgatac aaatctggga ggctgtttcc 1815001 cttttccgga acgatataag caacgagctc cttttcctca gcagaaacat cacgggccag 1815061 taccgctgct tcttttaccc ccggtgcttg tcgaagaact gtttcaatct ctctcagttc 1815121 aatacgataa cccctaattt tcacttgatc atcaaaacgt ccaatatatt caatcgttcc 1815181 atcaggcaaa aagcggcctg catcacctgt tcggtataaa cgctcccctt caaggaatgg 1815241 atgatcggag aatgctttct gtgtcagctc ttgctgtttg tagtatcctc tcgcaagacc 1815301 cgcgccggaa atacacagtt cacccgccgc gccgatcggc tgcatttgat ttccgtgcaa 1815361 aacaaatact tttgtgtttc tgatcgggtg tccgatcgtg atcctctctt ttttattcag 1815421 atgccgcaat attgttgttg ccacactgtt ttctgtgggc ccgtattcat ttgccagttc 1815481 agcagaagga caaattattt gattcaactc aagcagatca ggcgtgaccg cttcacccgc 1815541 aaatgtcaca atacgaagac tttttgcatc gtcagcagtc atcacttcca ataacaccct 1815601 gtacagggaa ggaacaatga tcatgtggct gaccttataa cgggctattt ttcgcttaag 1815661 ggccagcaca tccttcgctt cgtcatctgt tgtcagcagt acgcacgcac cagataaaag 1815721 cggggtaaat aagctcgtta cacagccgtc aaacacgtac gaaaacaaat ggagggatat 1815781 atcctgttcg gtcatgctat actcttcccg tctccattgc aatgtattgg caataccgtg 1815841 atgatcaact aaaacccctt tagggcgccc cgtcgttccc gacgtataga tcaagtaggc 1815901 tagatcacct ggcggcatat ttggcgcttc tgtttggtaa ctttctgtat gttctatcgt 1815961 tatcgtattt ccttcatagg acggagggat caaggaaata aggtcttctt ctatcagcaa 1816021 ttgagccgct tgactgtcct tcagaagaaa agaaagacgt tctgctggaa aatgtggatc 1816081 aagcggcata taagcgccgc ctgctttcca aatcccaagc agagctgcag gcatttccat 1816141 tgaccggccc atcattacag caacgatatc cccagatcca acgccttttt ctatcagggc 1816201 gtgcgcaatc tgattggctc ttacttgtaa ctggcgatag gtccagcact cgtttcccat 1816261 tttcaatgca gcagcttcag gtgttttgtg agcttgttcc tcaaacaatt ggggtatcgt 1816321 tttgttcaca taaggacgct cagtttcgtt aaacaattgg ataacctgtt gctcctccgg 1816381 cggcacgata ttgatgtcac tgacggcaac atcgggattt gtcaaaatgc aatccagtgc 1816441 ttgctttaga tgcccctgaa tcctcagcat ctcctcccgc tcgtaaacgt ctgcgttgta 1816501 gctgaatttg atataaaatg attctcccgg aacgataacg atattaaagt cgtaattggt 1816561 ttgttccgac attgaaatgt cactcagctt cagagcgcct tcgtcatttt cactctccac 1816621 gcttaatgcc tgatgaagct gtacagggta attttcaaaa acaaaaatat gatcgatcaa 1816681 cccttgcttc aatggactat ggttttgaat ctcataaagc ggataatacc catgctgttc 1816741 agatgataaa atatcctcct gcacggcttt gaccagcgaa gaaaatgtta tgccttccgc 1816801 agatcggatt cgcactggaa cagtattgat aaacaaaccg accattgatt caatcccgtc 1816861 aatcgctgac gggcgtcccg aaatgacgga gccaaaaacg gcatcatctg cagcattata 1816921 tcgatggagc agcacgcccc aaatactcat aaacagcgtg tttaatgtca ctccccagtt 1816981 ttgggcagcc tctgtcagtt tctcaaccat atccggcgct aatgaaaagc tgacctggtc 1817041 ggctttataa ttcccgtctg ccgtgcggcg ctttattcgg ggaatagaag cagtattgcc 1817101 gtactccttc aaatattcgc tccagtaggc agcagtctct tcttgatctt gttctccgag 1817161 ccattcaata taacggctgt acggcaccgt gctgccaagc tgtacaggtg agttattttt 1817221 gagcgaatca tacatgctga aaaactcttt aagaataatg ccgagacacc acccatccat 1817281 gatgatatgg tgatgtgtcc agacacatgt atattggctg tctcctctat caaaaagggc 1817341 aagacgcatt aaaggatctt tttgcaaatc aaatcctttt tcccgatcct tagtcataaa 1817401 agcatcaatc agcgtctgct gttcttgatc agccaggcga gaaatatctt ctctatatac 1817461 tgtcaattca cggtttgata gaactacctg ctgcggacct gtaagatctg gtacttcttt 1817521 aatgaaaatc gttctgaaaa tatcatatct agaaacaaga aggtttaagc tcttttgaaa 1817581 cgagtcgacg catagattcc ctgtgatcgt aaacgaggtc tgttcgatat atgctttcga 1817641 gctgaaatcc attagtgaat gaaacagcat tccttcctgc atgtgcgata acggataaat 1817701 atcttgaatt tgtgccgatt gtgccatcaa ttccacacac cttttcaaaa gttaaagatc 1817761 tttcacgaga tcttcgatgc tagataatgc agacaacgtt aattctttat tgctgaaatc 1817821 gctcaatgtt ttttcgcgtg cttttttctg cgaacaatgc tcaatcgtct cgataagatg 1817881 cctgtgaaaa cgatccataa agcactcaat tgagtgtttg ctgaacactt gggtgtatac 1817941 cgcttttacg tgaagccgtc cgtccgtaat gagagcattg atgtccagct catactctcg 1818001 ttctctctca cccgctattt cgtaacgggg ctggtaatat gataattgaa acgtttcaac 1818061 ttccttctct tcgctaaatt gaccgagata attaaagctg acctcaggct ctttatgccg 1818121 cagttctcct atgtgtgtta acaatccgta tccagttcct ttgttcggta ctcttctcag 1818181 catatctttt gtcgtcttaa ttcggtatgc gagctgatcc tcgaaaggct cgggaatacc 1818241 catgtctagc agaataggat aaatggaggt aaaccatcca actgtccttg aaatatcaat 1818301 gtttggcaca tgcccttctc taccgtgtcc ctcagtgctg atcacgattt ggtcatgccc 1818361 agtccattca gaaagcgcca ttcctaaagc cgtaagcaaa agttcgttgg catcagtacc 1818421 ataggcttgc tgggtttcaa acagcaattt ttcagtccag tccccggata gtacaaacgc 1818481 tgctgcgtcg ctgttcattt ggagtttgtc tggcacattt tctatgtcct taggaagaaa 1818541 agcagtgtga gcgtctaaaa tcgtttgcca atacgttttc tctgaaagca attgtttact 1818601 ttcagctatt tgggtaagac catcggcgta ggataaataa gaatccgttt ttggcggtaa 1818661 ttggatttct ttcttttcta aagcctgttg atatgctgca gctaaatcct caagcagaat 1818721 tctccaagaa acgccatcta tcacaagatg atgaagtgca atcagcaaat gatccccttc 1818781 tgccgtttta aacaaacctg cttgcagtaa gggccctttt tctacattca ttttgctttg 1818841 aatgacggtt tcctcagcgg caagtttttc atcaagatga gccctttcca gcgatgcttt 1818901 tgtccaatct gaaatataaa ggccaaacag ttcatgatcc ttgtgattga ttccgcgatt 1818961 aaactgaatg acatggccgt tttggtcacg ttggaaaatc atgcgaatgg catcatgatg 1819021 ctcggttatt ttacgcagcg ctagatgaag cgcgttagca ttgaatcctt tttcactgaa 1819081 aagcatgacg gactggttgt aatgatagtg aaaagcatgt acctgtccga aaaatcttcg 1819141 ctgaatcggg gtgagttcag cttcaccttc cgcaggtccc tggtccgctt gagatgccaa 1819201 tggtgtgata tgtccgcata gttcctgaat cgttgaataa cggaataagt cgcgtattgt 1819261 catgctccag ccttcagctg ccagacgtgc tgccacttgt aatgctttaa ttgagtctcc 1819321 gccaagctca aaaaaggaat cgtgaatgcc gactcgtgac atgctcagta catcttccca 1819381 tatatacgcc atcgtttttt gtaagtcgtt aactggtgcg gtatatggac gcgataacac 1819441 attatttgga gccggcaagg catttctgtc cagctttccg tttagggtca gcggcatgtt 1819501 tactaaagga atcagatatg caggaatcat atacgctggc agttcctttg ttaaagcagc 1819561 acggagagca ttcgtattga cgtctgaagg cacaatatat gctgccaaac cagcctgtcc 1819621 atttttatca tgctgaacgg caacagcagc ttctctgaca agccccgttt gaagcagaac 1819681 actttcaatt tcttctgttt caattctgta tccatttatc tttacttgat aatccattcg 1819741 gccaagaagc cggatcgttc cgtttggaag ccagcatgct cgatcaccgg ttctgtacag 1819801 cctttctcca gagacaaatg gattttctgt aaatttcatt tgcgttaagt caggtttatg 1819861 atgatagcct ttcgcaacac ctgccccgcc gatgcacagc tcgccggcaa caccgatcgg 1819921 ctgaatttga tcagtctggc tgagtacgta catgtgtaca ttcggcagcg ggctgccgat 1819981 tggtacgtta tctcccgtac actctccacc catactggtt tcatagaaac tcgaatcaat 1820041 ggttgcctct gtgacaccat agctattaat gatgcgcatg ctttggccaa agcgatctgt 1820101 caatgttttg aaatcttgag ctttcaccat gtcggaacca agaatcagta tgtctaagtc 1820161 aggaagcttg aactggttac ggtatacata ctccatcacc gggataatga gagccggtgt 1820221 cgactccatc accgtgattc tctgagattt aatgatttta tatatttcag caggttccag 1820281 ccgtgtttca tctgggcaaa cgattagagt cccgccgttg gtcaatgttc tcgccaaatc 1820341 tcctgagaag acatcgaatg aaaagctcgc gatttgaagc agtctgacag gcttccgatc 1820401 cagttcataa atttgacgcc aagcaagagc agcatgagta aagttctgat aggtgacaat 1820461 aacaccttta ggcgcacccg tcgttcctga cgtataaatg atatataccg gctcttcagg 1820521 agcaggagat aagttaaggt tgcagttact ttcttcaaaa gagccctcat cgtcaaggaa 1820581 gatgtgagac atctcagatt caggcgagtt cgaaatcaaa tgcttcaact ctctctgtaa 1820641 aagaagaata tctgccccgc tatcacgaag aatgtattca atacgagctt ttggataatg 1820701 tgcatcgatt gggatataca ctccgccagc tttcatcact gccagaactc caacaattgc 1820761 atcgatggac cgcttggcta aaacagccac agttggcttc ggtccttttc tgttttgcaa 1820821 tgttcgtgcc agacgattgg ctctttcatt tagaaggcga tagctaatct ctgtttcgtt 1820881 atcaataaca gctatatgtt ctggattttc ttcagctttc gcttcaaata tgcgatgaaa 1820941 aggaatatct ttttgagcaa attcaacttg agttttgtta aattcaaaga ctattttttg 1821001 tttttcttta tcactaagta tgtttatttg tgcaaggctt gtttcaggag ttgaaagtgc 1821061 ctcatgcaga aattcgataa aatgatcagc ccagcgttca atcgtagctt tcaggaatac 1821121 ttctgtacta aattccattt cgcagcaaat agatccactt atttccgtag ctattaatgt 1821181 gatatcaaat aaggaaatgt gatgtgcgaa attggcaggc cggactttta tttctctcag 1821241 atctatgtct tgtttttcca cattttgaag gataaacatc gcatcaaaca ctgggttccg 1821301 gctcatatct cgtgtcaatt caagcttatc gacaagctct tcgaacgggt aatcctggtg 1821361 ctcaaaggct tccaatgctg tctcacgcac ttcctgcaaa tactgtacga atggcttccc 1821421 gccctccggg cgcgtccgaa gcgccagcgt gttcacaaac atgccgagta tcggctcaag 1821481 atccttgtgc ggccggccgg caattggcga gccgacgatg atatcttcct gtccgcttaa 1821541 gcgtgacaag aacgcggtgt aagccgcaag aagcaccatg tacagtgtgc ttccgttttc 1821601 acgtgccagc ttgtgaaggc ctgatgcaac ctcttgatcc agcgtaaatg agaccttgtc 1821661 acccgcgaag cttcgcaccg gcgggcgggc atgatcagcc ggaagatcca gcacaggcag 1821721 ctcgccctcg agctgcttca gccagtacgc ctcttgcgtt ttgtacgcgt ctcctgtttt 1821781 gaatccttct cgccatacgg cataatcttt atattgaatg cgcagtgccg gaagattccg 1821841 attattgtac agctcgccga attcccgaat cagaatgttg acggaaacac cgtctgaaat 1821901 gatgtgatgc atatcaacca gcaacaggtg ccgctcatct gatatcttta cgatttgggc 1821961 acggaacagc ggcgcttggc tgagatcaaa cggtttgata aatgcggctg cggcctcctg 1822021 ttcggttcgt tcgccgagaa ctgtagtctg taacgtaaac ggcacctcgt catggatgcg 1822081 ctgcaccgga tcgcctcctg cgtcctgttc gaaggaggtc cgaagcgact cgtggcgctt 1822141 gatcagctct ttgaaagctc tctccatcct ttcagggttg agcttccctt cgagctctaa 1822201 cacagccggc atattgtagc ctgtccctcc gtcctccagc tgctgaagga cataaatccg 1822261 cttttgggca gaggaaaccg gataggtttc ctgtttttca gcgggcttaa tcgcttcata 1822321 tggactgtcc gttccttcac ggataacggt agccagtcct tctactgtcg gatgggcaaa 1822381 cacatctttt agcggcacct gtacatcgaa ttctttggcg atccgtgaga caagcgccgt 1822441 tgcttttaag gaatgtcccc cgcggtcaaa aaagttgtcg tgaatcccga cagggccatt 1822501 tttcagcacg tcctcccaca gctgagaaag cttcatctca gtcacgtttc tcggcgccgt 1822561 gtaggtctcc gcatctgccg ctccgccagg agctggcagg gcgtttcggt cgagctttcc 1822621 gcttggcgta accggccact gttccatctc tatcatatag gctgggacca tgtagcccgg 1822681 caacagtctc tcaagctgtg cacgcacttc gtttctttgg agcccttcta cataagcgca 1822741 taattccggc tccccgctgt ctgtccgtac ggtaacagcc gcctctctta cgccttctat 1822801 gcttcttagt gccgcttcaa tttctcccgg ctcaatccgg tagccgcgga tttttacctg 1822861 atcatccgtg cgcccgagga attcaacatt cccgtcaggg agccagcgcg ccacatcccc 1822921 ggttttgtac atgcgttccc ccgggtaaaa cgggtcttca agaaaacgct cctccgttaa 1822981 tgccggccga ttcaaataac ctctggcaac acccgctccg gcaatgtaca gttcgccggc 1823041 gacaccggaa ggctgtacgg ctaaatgcgg atctaaaaca tacaaacgcg caccaggtac 1823101 gggcttccca atcggaatcc gcaaacgatc cctgtcccgt tctggatcca atacgtaaaa 1823161 tgccgcgtct accgttgctt ctgtcggccc gtaaccatgg attaatgata cctgcggcaa 1823221 tacagaagca aaacgggctg ccgtacgcgg cgcaagcggt tcacctccgg cgaatacacg 1823281 ctttaggctt gtcctgtcac tcagcctttc gatttccgct tgatcgagaa agctgttcag 1823341 catagccgga ataaaatgag ccgttgtcac gttttcctga tgaatggctt gtacgatcaa 1823401 tgcggagtct ttctcccagc cgggcggaag cagatacgcc gaagcaccgg aaagcgacca 1823461 ccaaaacagc tgccacacag acgcatcaaa ggaaaaagag gttttcacca tgacaatgtc 1823521 atcttccgaa agcggaaact ggtgctgcat gccggtcaga aaggaaacag cctgacggtg 1823581 ctcaacggcc actcctttcg gctgcccggt agagcccgat gtatagatga cataggcgag 1823641 agatccgccg tcagcaggag taaactcatg gttttctgct ttttcgctcg caagagatgt 1823701 catgtccact tcaagcgttt cgccagaaaa gtttggtgcg gagcatcccg gctgtgtcag 1823761 caagagcgat gccccgctgt ctttcagcat gtagctcagc cgctcctttg gatacgcagg 1823821 atcaagcggc aaatacgccc cgccggcctt caatacagca aggacagcga tcagcatgtc 1823881 aggtgagcgt tcagacagga caccgacgat actttcgttt gtgacgccgc gtgccgcaag 1823941 gtgcgcagcc agccggctgg cgtacatatc aagctcagcg tatgtcagcg aaccgcctga 1824001 aaagcgaatg gccagccgct ccggtgtgaa agctgcctgt cgctcaaaca gcccatgcag 1824061 ggtgaaagct ttaggcgaaa cagcttccgt cttgttaaac tcatacaaca atttttgctt 1824121 ttctcttgta ttcgtcatat ctaattctct tataaagctg tgcggatgtt taagggcgtt 1824181 ttccagtatg gtaagcagat gagattgtat tcgtttaata tcctcaagag aaaacaaggt 1824241 attttgatag tcgaaattta attgaatggt tccattgtct atccgttctt gtatttgaac 1824301 tgaaagttcg ttcgcggtgt atccgctgaa ataaagcgct gtttcatagt caaaatcatc 1824361 tgcattgtgc cactgaagtg gctgatactg catagatata ccgataaggt tgtgtaaatc 1824421 cttctgttca tttcttaatt catttacaag caaattataa ggaaaccgtt gatgacgcat 1824481 aacagaaagc tgttccctgc ctattgtgcg gacaaaggaa agaaaatctg tgtcaggatc 1824541 aaccgttatt ctgattggaa gggaactaac gaacatgccg agcatttctt tttcagcctt 1824601 tgaacctctg ttgccatagt aggtgccaat ggcaagatct tttttagaag tgattcggct 1824661 gatgcatatg taaaatgaag ccataaataa ggaaatgata ttgatcttgt gttcttcgca 1824721 gaagattcga atcgtttgct ctagatcagg tgaaagaatg atggtgtctc tggatgcaga 1824781 tgtgctctgt ttttgtaagg acgtctggtc ggctaacgag tggtattcca acgggtgctc 1824841 aaaggtttgc gtccaaaata aacggtcctt tgcaaaccgt ggagattgta gatattgact 1824901 ctctttttcg atgtagctca agtaagaagg ttccggctga tcaggtaaag gatctttctt 1824961 tttcattttt tgataaagat ctataatttg atttcccatc acatttaaag agattccatc 1825021 cattatgata tgatggaatt tcgcaaatag ccaaacttca tgagagtcaa ttctaaggag 1825081 gtaaaattga aaaagaggcg agttgaacag tttaaatgga atgctcgctt gatcctgaat 1825141 ccattgctct atttctatca tttcaacatt tgaaaaatca attattctaa gtggataata 1825201 tttatattca gtaaggtgca atcgaggctc aagctcttct ccttctaaca gctgaaatct 1825261 aatggcgtcg ttgcgggaga tggaatgatt cagtgctccc tccagagtat caagctcaat 1825321 attgccttta aatttcacac aagctgtaag attgcaaatg ctggtatctg gctccagcag 1825381 ttcggtaaac cacactctcc tttgggcatg ggttaaagaa taagtatgtt cgctcaacgg 1825441 attccctcca gttctcataa taagaggata agaaaatgta gaaaaaagca gaaaaatgac 1825501 aataaaagaa attatatgac tatataatcc atatatgcac tatattaacg gatatttttt 1825561 aaagtacaat aaaaaacatt aaatttttat aacatttttt ttgaatatag tattatttct 1825621 ttatttttcg tttctttttt tatcaaattt ccggatataa agtgataaaa gtattgtttt 1825681 acataaggtc ttatacacta ctttttaatc ggactaattt tcttttgtgc atcattcttc 1825741 taattgttgg aaggttcgac aaagcgttat tacagacata aaaaaacctg ttttctcttg 1825801 gaaaacaggt ctcccgctat tattgatttg ccaaaatgac agcgatttga tcctcaatat 1825861 cttttccatc ctcttcatca atcaatccat ttagaagaat agagaaaaca agtttttttc 1825921 cgctctttgt ttctgcgtac cccgatagag agcttaccgt actgagcgat ccggtttttg 1825981 ctcttacttt tccttgtgca ggagtgcctt tcatgcggtt tctcagcgtt ccgcccacca 1826041 ttctgtcagg attccccgca acaggtaaag aatttagata agccgagaac caactctgat 1826101 cctgaatgtc atataacagc tgtgaaagtt gatctgagga tacagcatca atatgtgaga 1826161 ttcctgatcc gtcccttaag acgagtgatt tagaatcaac accaaattcc ggaagcgtac 1826221 tgtttaacac ttcgagcccc ttttcccagc tcccttctcc ttttttcact ttccccatct 1826281 cttttacgag cacttcggca tgtccgttat tacttaattt catgaacggc acaaaaagtt 1826341 tcgataaagg cattgagcga tgagagagca gcacatctga agaactaggt gcttcacccg 1826401 tcttgatgtc ccctttcaca gtaatacctt gtttttttag tgactgctta aataaatcta 1826461 aggcatatcc ggcaggctcc cagacagaaa tccattcctt tgtcttgttt gcgtcaaccg 1826521 gtacgctccc ttcaattgta atcgtgtttg ttccatgctc tctttcgatt gtgaggtctt 1826581 tctctgaacc ggcagcagtc gttttagcat cgttctttat cgttatataa tcggttttcg 1826641 gagagacaga cacggcaggc tcttcccctt ctttttgatt tggggtgacc tcaacaatca 1826701 cagtgcctgc atcatagtct tcgtttggag acgctgttag agcggagatt ggcgcgccat 1826761 aatatgtgta ttcatcgctc caaggcatat caggtgataa tcgcatgtca tcatgccacg 1826821 tatcatcacc gatcagattg cctttaatta cttttacgcc ggaatgtttc aatatctcag 1826881 ccattttgtc aaaatcagat ggtaaaagtg tcggatcgcc tttccctttc aaataaaggt 1826941 taccattcag ctttttccct ttcagtgttc catccgtccg gacctcggtt gtaaaagaat 1827001 agttctcgcc aaggacagaa agtgccgcgg ccgctgtcaa aagctttaga gaagaggcag 1827061 gcctcattcg ggtgtctcct gaatgttcat atagaacagc acctgtttcc gcagagcgaa 1827121 cggtgatgcc ggccattgcg ccttcgaggg caggatgatc agctaaaatc ttatcgatct 1827181 gcccggaaag tgcatcttgt ttttcagcgg caagcgcagc ctgatgcata taaggcaccg 1827241 aagcaacgac gaaaagcagt aaaacagcaa cataaagctt tatgcttttt ttcattaatt 1827301 tccccgcctc tctgcgcttc atcattggct attgatgatt cagttcaatg gtgatactgc 1827361 ttttagctgt cgtttcttct cccggctcca gcacttgtaa accagtgagt gacgaaggta 1827421 aatcaagatt cactgcgttt gtcacccatg tgtaaggctc agggcataaa tacccttgtt 1827481 ttccgtccgc attgtataca acccaatgtt taaactgttc atctgcctta taaataatgc 1827541 tgatatgtgc atgctgatga taaatgactg cctggttttc tccgcccctc ttctgataag 1827601 aagataaaaa gacatcatcc agctgcttgt ggcgcaaatc cattccttca tgcaaagctt 1827661 ctttatacgg gacatccatc agcttcccgg tcggcagcag gcgttcatcc aactcccatt 1827721 gctgatctgc tgtcagggag aataacgagc tttctgccgg aaatataaat gtagtatgat 1827781 aaccaattcc ccaaggaaac gcttcctttc ctttgttcat gaccgtcgca tgtttaaata 1827841 gggtattctc cttgatcgtg tatgtcatcc gaacgacggc atgatgagga aattgcttct 1827901 gcacatgggg aagctcagaa agatcaattt ctgtttcaac aatcactcct tcatcagttt 1827961 gcttcgtggt cacgacattc cacttttcat ggtaaagaaa cccgtgaaga tggttgtgtt 1828021 tatccttctc gttgatatca aaatgatacg ttctgccccg gaaactgaat gtaccgtcac 1828081 ttatgcggtt aggcgggaac aggattggaa tgccatacaa tgttggtgtg tcgtgaaaac 1828141 tttctgctgt ttccggttca cgcaaaagct ggacatttgt tgttttgtcc acgagagaaa 1828201 tgacgttgct cccccactca gggacaacaa tcatttctag atgttcgttg cccgctttga 1828261 tggccggcgt tcccaaatac gtgattttct caataaagtt tgccatgttt actcaacctc 1828321 tccttgattc attgctagta taagaattca atgtactgta ccatatttcc tccattttat 1828381 attttcccct atcaaataaa aaaacaccgt tcaaacttat gaacggtgtg attcggaggc 1828441 tattggatga gacgtgtgat ttgtttcttt ttccagacga attgataata cccataaatc 1828501 aacagcaagc tgacggcaaa cgcagctgga taaccaaccc agacgccgag tatttcaagc 1828561 tttgtatagt gagaaaggac gaaagcgaca ggcacctcta ctccccagat tgcaaaaata 1828621 ctgatgacgg tcggccataa aactgttccg cttgcccgca tcgttgcaga aataatttgg 1828681 gcatttccaa acagcaaata gctccacagt gtaatcatca aaagacggtg cgcaatgtaa 1828741 agcgtctctt gctcggttaa aaataacgat aaaatctgat gtgaaaaaac atagatcaga 1828801 atgatcagta cgccgccaat gatataattc agccaaatcc caacgcgaat gacctgcttt 1828861 aagcggtcaa actcgtttgc tccgatcgat tgcgcagcga aaatagaaac cgcaatacca 1828921 aggctgacgg ccggcatctg tacatagctg gccacctggt tgaccactcc gtatgcagct 1828981 gttgcattag agccgtaatg attgacgaat gaaataaccg ctatctctga taatgagaca 1829041 agaatcatat tgatgcttgc tgggacccca agacgcagca ggagaaccag cagttcctta 1829101 tccattttca aataacgacg cactgtttta tcaaattgca gcgggtgttt tcgctttcgt 1829161 aaatacacca ttaacacgag aaaagtcgca atcgtggaaa tgacagttgc atatgccgag 1829221 ccgtatatgc ccagtttcgg aaaaccaaac atgccaagga ttaaaacagg caaaagcgcg 1829281 atgttgatga ccgtgctcac aatcagcgta taaaacggtg tcttggaatc tcctgttccg 1829341 cgcaaaaagg tagtatatgc aaaatataaa aacataaacg gcatagcata aaataaaata 1829401 cgtgcatagt tagcgctgac atgaatgaca ttttcaggtg ttcccattaa acgaaggata 1829461 tccagggtga aaatactgcc gataacggct aacacaacgc ctaataaaaa tgtaaacgtg 1829521 agtgtcgtcc cgacaacagc ctttagccgt tcctcatttt tcgctccgta agcttgtcct 1829581 atcagaatcg aacttcctga accgatccca atcgtaaatg agattaaaag aaaaaataac 1829641 gggaaaaagg atgatacagc tgccactgca tcaacaccga gccatctgcc tacagccatc 1829701 atcccgacta gctggccgac tgattgcagc acattgctca gcagaagcgg cactaaaaag 1829761 agtgacatcg accgccaaac tgatggtttg cttttctttt gagttacaag aggttcttgt 1829821 gatgtttcca tattaaagga ctcctttatt tgaaatcgtt tttaaacatg ccctcatttt 1829881 ttgacaaaaa caggatatgt aacatgttat tattcatcac tgcacttatg aaacccttcc 1829941 cgattcttct aattttacac atctttttag cttatgaaga ataaactagc aagtaatggc 1830001 gtattttttg tgagtaaaag aataaaaaat aatttatgca aaagtattgt aatctatccg 1830061 taattattgt aacatttgta acataagaga aagagatttt gaaggagaga gcgataatga 1830121 aaaaatgtct tctatttcta acaaccattg cacttattct gtcattaagc acaaatgcat 1830181 ttgcgaaaaa tacatcaggc gatttatcac aaaaacaagc attacagttg gcattatccg 1830241 ctagagaaca tttttggaac accatgagcg gccacaatcc gaaggtgaaa aaagcagttt 1830301 gcccatcagg cacattcgag tatcaaaatc ttcaatatgt atacatgtgc agtgatctag 1830361 gcactaaagc aaaagcggtg aattatttaa ctcctatttt tacaaaaaca gcaatcgaaa 1830421 aaggctttaa agattatcat ttcactgttt caaaaggaaa acttgctgtt ccaatcggtg 1830481 acggagacaa tcttttgaat tggaaaaaat caactgctaa actgatctct aaaaaaggca 1830541 gcacaatcac atacgaattt actgtcccta cattagacgg atccccttct gcaaaacgga 1830601 aagtgacatt tgtgaaagaa aataaaaaat ggaaagtcaa tcaatttgac gcagttatat 1830661 aagaaaaacg cccggtataa gcgggcgttt tttatttggt ttgcataaag aaagacaaca 1830721 ggcgaaaagt gcctgttgtc tttttgtgaa tataacgctc taggagagat tcgaactccc 1830781 gacctgcagt ttaggaaact gctgcactat ccgctgtgct actagagctt ttggtattta 1830841 tatagtagct ctgatgatca atattttcaa gcgatttgta ttaaagccct ccaaaaacct 1830901 tatatgcggc tcttgtcgta tcttcatcaa taccgatata ccgcattgta attgatggtg 1830961 atgaatgatt cagtattctc tgcagctcgg cgatgtcttt cgttcgctga taaaaatgat 1831021 agccaaacgt tttccggagt gtatgcgtcc ctatctcctc aagtccgcac gctgcagcgg 1831081 cctctcttaa aattctgtag gcctgaatgc gggaaatcgg cttcctggtc cgcactgatt 1831141 taaaaagata ttcgttttcc ttcatgtctt tcgtatactc gtatatttcc tgtttcagcg 1831201 attctaaaat aagaatcttt cttttctttt tcgttttgct ttcagtcgcc cataaatgat 1831261 ctttattttg aacgtccttc acttgcagcg gcagaatatc agaaatacgg agcgcgctgt 1831321 tgatgccgaa aataaacaga aaataatccc gcttgttttt gttaagcaaa tactgtttga 1831381 cttcttggat tttctctaga ctgcgaatcg gctgtacaat atgcatcaaa aaactcctta 1831441 aaaaccgtta tgtaacattt tgaggtctat gttactatta tagctgaaaa acgttgaatg 1831501 tcaaagtgcg gcggcgttta tgtaacataa tatacatagt gttacataag cttttaaaaa 1831561 agcttcttcc aaccttcacc ctataaaata agctttaaag cctcttataa agcttttaac 1831621 ctcttggata cttatccccc tactaatcat caaaaaacct cttaaaatga aatctgacac 1831681 tcccaatttt ctggagcttc cgcaaaaata tacaaaaaaa gacacaattt caaattgtgt 1831741 cctaatcctc atcctttaca tcaatatctt ccgggatcgg ttcatttaat atttcctgca 1831801 caagtgcttt gtaattctcc agctgttcga gatgcgtttt gaactgttcc ttataaatca 1831861 aaaattgctc cccgtcatga acggctctga ttttcccttc gagcaccaag cttttaatat 1831921 aatcctctga aagatttgta tattctgctg tttcttcaat cgttaaatac atatagcagt 1831981 cccttcttaa tccgtatgct gattctaata tagcacatgg ctcatatcaa tataatcaat 1832041 tctgcacaga aaaacggcat tatgcactat ataatatacc atttgtcact tgtgaaaacg 1832101 ctgtaatttt tttacgctaa gattgtaaca atacagcttc atataggagg gagaacatga 1832161 aaagaacgtg gaacgtctgt ttaacagctc tgcttagtgt tctgttagtc gctggaagtg 1832221 tcccttttca cgcggaagct aaaaaaccgc ccaaaagcta cgatgagtac aaacaagtag 1832281 atgttggaaa agacggcatg gttgcgaccg cacatcctct tgcttctgaa atcggtgctg 1832341 atgtgctgaa aaaaggagga aatgctattg acgcagcggt tgccattcaa tttgcactca 1832401 atgtaacaga gccgatgatg tcaggtattg gcggcggcgg ttttatgatg gtgtatgacg 1832461 gaaaaacgaa ggatacaacg ataatcgaca gccgtgagcg tgctccagca ggcgcaactc 1832521 ctgatatgtt tctggacgaa aacggcaaag caattccttt ctctgaacgt gtaacaaaag 1832581 gtactgccgt tggtgttcca ggcactctga aagggctgga agaagccttg gataaatggg 1832641 gaacccgttc gatgaagcaa ttaattaccc cttctattaa actcgctgaa aaaggctttc 1832701 cgattgattc ggtgttggca gaggccattt ctgattatca ggaaaagctt tcacggactg 1832761 ccgcaaaaga tgtattttta ccaaatggcg aaccgcttaa agaaggagat acccttattc 1832821 aaaaggattt ggctaaaaca tttaagctta ttcgctccaa aggcactgac gctttttata 1832881 aaggaaaatt cgccaagacg ctttctgaca ctgtccagga tttcggcgga tcaatgacag 1832941 aaaaagattt agaaaattac gacattacaa ttgatgaacc gatttgggga gattatcaag 1833001 gctatcaaat cgctactact cctcctccaa gctccggcgg tattttctta ttgcaaatgc 1833061 tgaaaatcct tgatcatttt aacctttcac aatacgatgt ccgctcatgg gaaaaatatc 1833121 agctgcttgc tgaaacgatg catttgtcat atgccgaccg tgcgtcttac gcaggtgatc 1833181 ccgaatttgt aaatgttcct ctcaaaggcc tgcttcaccc cgattatatt aaagaacgcc 1833241 agcaattaat caacctagat caagtgaata aaaaaccgaa agccggtgac ccttggaaat 1833301 accaagaagg atcagcaaac tataaacaag ttgaacagcc gaaagacaaa gtagaaggcc 1833361 aaacaaccca ctttacagtt gctgaccgtt ggggaaatgt tgtttcttat acaacaacaa 1833421 tcgaacagct attcggaacg ggtattatgg tccctgatta cggtgttatt ttaaacaatg 1833481 aattaacgga ttttgatgcg ataccaggcg gagctaacga agtacagcca aacaaacggc 1833541 ctttaagcag catgaccccg acgattttat ttaaggatga caagcctgtc ctcacggttg 1833601 gatctcctgg cggggccaca attatttcat ccgttttgca aaccattctc taccacattg 1833661 aatatggtat ggaattaaaa gcagctgttg aagagccgag aatttacaca aacagcatga 1833721 gctcttaccg ttacgaagac ggagttccta aagatgtcct cagcaagcta aacggcatgg 1833781 gccacaaatt cggcacaagt ccggtggata tcggaaacgt gcaaagtata tcgatcgacc 1833841 atgaaaacgg cacctttaaa ggtgtagctg attcaagcag aaacggcgcg gcgatcggca 1833901 ttaatttaaa acgtaaataa ataaaaaact gtactcgctt caaatgagta cagttttttc 1833961 atgcagatct ttaaaataaa aactgacaaa cgtctttatt ctgctaatgc acgtctatct 1834021 tcatcttttc atttcgttta tctcatcaag aaatgtctga aacgcactcg taataaaaaa 1834081 gtctttcctg tatataaaga cgatctctaa gtcttgatat gatggtggca gctgatgaat 1834141 ccatacattt gtacgatgct cggagccgtc aacagcggac tttgggagca gcgccgtacc 1834201 catcccggcg gaaacacctt ttataatagc ctccaatgtg ccaaactcta tgattttttg 1834261 attgtgtatg cctgcttcct ctagtaatct tttgaccctg tcacgatgag aacagccagc 1834321 cccaaaaaag agcatcggct gctgaagcat gtcttctgcc gtcccttctc gtgatgaaat 1834381 caaaactaat tcatcatggg agacatggag ttgtctaact gcagcgtgtt caaccggccc 1834441 atatacaaaa gcgccatcaa ctttatgatc aagaacctgt tgaatcaaat gatgcgtatc 1834501 agctgtgttc actgataaat ccacttcagg aaaacgcctg aggaaggatg ctgcatgctc 1834561 aggcagatgc gttaccgcca ttgtttccag tgatccgatc cgcaaaggcc cttttggttg 1834621 cctgctcatt cgggtcgatt tttcagcttg gtctaacagc gataatactt gatctgcata 1834681 ttgtaaaaga ttttctcctg cagcagtcag cttcattccc cgattcgttc gatgaaaaag 1834741 cctgatattc aaatcttcct caaggttatg cactctggct gtcacattcg actgaacata 1834801 attcagcatt tgggctgctt tcgttatgct tccttcgcga gcaacagcct gaaaaatctt 1834861 taaatctccg ctttccacgc gctctcacct gcttgctatg atgaaaagtg atattggcta 1834921 tcatatttgt tcattttact cgaagaaaac cgctatgtaa aatatgtaaa gatatgaaaa 1834981 tacaattaat gaggaggcag acagcatgaa agctgtaatt cacaacggaa aagccggtct 1835041 tctggggtta tcagttcagg acgttccatc aacaaagcct ggatacggag aggtaaaggt 1835101 taaattaaaa tctgcaggcc tgaatcatcg tgacttgttt cttatgaaaa acaaatctga 1835161 acaagatcct cacatgatac tgggttctga cggcgcgggt atcatcgaag agattggtga 1835221 aggcgtgaaa aatgttactg ttcagacaga agtagtcatt ttcccgacat tgaactggga 1835281 tttgacagaa aatgttccac ctgtacctga gattctggga ggtccttcgg acggaacact 1835341 tgctgaatat gtgatcattc cttcacaaaa tgcaatcaaa aaacctgctt atttatcttg 1835401 ggaagaagcg ggcgttttac ctttatccgc tttaactgca tatcgggctc tgtttacaaa 1835461 ggggcaatta aaaaaaggcg agcatctatt gatacccggc atcggcagcg gtgtagcaac 1835521 ctacgcttta tttatggcta aggcgattgg ggcaacagta agcgtgacct cccgcagtga 1835581 ggagaaaaga aaaaaggcgc tgaaattagg tgctgattac gcatttgaca gctacagcaa 1835641 ttgggatgag cagttgcagg gaaaaaagat agatgttgtt cttgacagca taggacctgc 1835701 cctcttttcg gaatacttcc gccatgtaaa accaaatggc cgtattgtca gctttggggc 1835761 aagctcaggg gataatctca gttttccggt gcgttcttta ttctttcctc aggtcaatgt 1835821 tttgggaacc tcgatgggaa gcggtgagga atttcaagct atgctcgctt tcattgacaa 1835881 acataagctg cggcctgtaa ttgaccggat atatccttta gaaaaagcat gtgaagcata 1835941 taaaagaatg caggaaggca gacagtttgg aaacatcggg atcgtaatgg aataaaaaaa 1836001 gaaaccggct ggcagccaga ccggtttctc ttatatgata atccccttta tttacggaag 1836061 aactgaactc cccatcaaat atcgatccac ttcacgcgcc acttcacggc cttcattaat 1836121 cgcccatacg attaagcttt gccctcttct tgcatcccct gcggcgaata caccatcgat 1836181 atttgtttga taatccccat atgctgcact gattttgtta tttactgaat taacaccgaa 1836241 ctgtttcaac agcggctgtt ctgtgccttc aaagccgata gcgataaaga caagctgagc 1836301 aggccatact ttttccgttc caggcagctc gcggaactcg tattttccat gctcattttt 1836361 cactttttcc atttggatgg tatgaagctc tttcagcttt ccgtttttat ccgcgaccat 1836421 ttttgtcgtt tgaatggagt attctctcgg atctcttccg aattttgctt ctgcttcctc 1836481 gtatgcatat tcaagcgtaa agacgtgtgg ctgttcaggc cacatattgt cattcgtgcg 1836541 ggctggcgga agtttcgggt gtttgccgaa ttggtgcacg cttttggctt tttgacgcag 1836601 agcggtagcc acacagtcag ctcctgtatc tccgcctccg attacgatga catctttccc 1836661 tttggcatca atgaattgct tgtctttaaa attagaatct aaatagcttt ttgttgcaag 1836721 tgtgaggtag tccattgcgt aatggactcc ttttgagtcg cgtccttcga ttaagaggtc 1836781 ccgctgtttt tgagcgcctg tgcataagat cacagcatca aattgctcct ttagctcatc 1836841 agctgtaatg tcaacaccga tttctgtgtt cgtgacaaaa tcaattccct cttgcgtcag 1836901 caatttaatt cggcgttcta caatgccctt ctcaagcttc atgtttggaa tgccgtatgt 1836961 taaaaggccg cccgctctgt ctgctcgttc aaaaacagtg acggaatgtc ccgcttgatt 1837021 cagctggtca gcactcgcca gtccggctgg gcctgacccg acgatggcca cttttttgcc 1837081 tgttcgtttt tttggaattc taggttgaat ccagccgttc tcaaatcctt tatcgataat 1837141 ggtccgctcg atgtttttaa ttgatacggc cggatctgaa atcgctaaag tgcatgatcc 1837201 ttcacaagga gcggggcata cccgccctgt gaattcagga aagttgtttg ttttcaacag 1837261 acgttccaat gcttccttcc atctgccccg gtagacaaga tcattccatt caggaattaa 1837321 gttgtaaatc ggacagccgg atgtaaatcc gttaatgtcc gcaccgatct ggcaaaacgg 1837381 tgtaccgcaa tccatacacc gcgccccttg ccgtttcgat gcttcttctg aaaaaggagc 1837441 agaatattct ttccaatcct ttaagcgagt gagagggtcc cgctccgcag gtttttctcg 1837501 tttgatctcc ataaatccag ttggtttccc catgttcctc tccccttcct tactgtacta 1837561 ccgcttgttt ttgtcccgat gctgctgtat tctgctttgg cttcgtgttg gcctcaaaag 1837621 cgaacatgat ggcttcttca tctgataaac ctgcagcttt ttgctcttcg atgcttgcga 1837681 gcatttgttt atagtttttc ggaatgactt tgacgaattt tttcacactg tcttcccatt 1837741 gatctagcag atcttctgct ttttggctgt ttgtatacgc agtatgtctt tcaagcattg 1837801 ctttgatttg ctggatttct ttctcatcct ctaatgattc aaataaaatc atctcaaggt 1837861 tgcatttgcg tttaaacgct ttgacatctt cggtcagtac ataagcgatt ccgccggaca 1837921 tacctgccgc aaagtttttg cctacatcac cgagaacgac aacgctgccg ccagtcatgt 1837981 attcacagcc gtggtcgccg atgccttcta caactacgtt cacaccgctg tttcgaacgg 1838041 caaagcgttc accagcacgc ccgttaatat atgcttctcc gcttgtcgca ccgtaaaaag 1838101 ccacgttgcc gataatgaca ttgtcatccg aagcagagtt gaatccttct gatgacttga 1838161 cgatgatttt tccgccagaa agcccttttc cgacgtaatc atttgagtct ccgtccaaat 1838221 aaagcgtcat ccctttagga acgaaagctc caaagctttg gccggctgat ccggtaaagt 1838281 gcagcttgat tgtatcttca ggaagacctt cttctccgta acgctttgag atttcactgc 1838341 cggttatcgt tccggctaca cgatttgtat tattgatttc aatcgaaata tcagcttctt 1838401 ttccagattc gatggcttct tgtacggccg ggagaattgt tgtaatatca agtgattgat 1838461 caattttatg attttgcggc gattggaacg tccgcacccc ttcaggctga taaagaaggg 1838521 tagacaaatc aagctggctt gctttccagt gctcctttgc ccgttcactt gcatgaagta 1838581 catcagtgcg gccgatcatt tcatcaaatg tcttgaagcc taacgcagcc atgtactcac 1838641 gaacttcttc ggcaatgaac agcatatagt tcacaatatg gtcaggatct cccatgaact 1838701 ttttgcgaag ctctggattt tgtgtcgcta caccgacagg gcatgtatcc aaatggcagg 1838761 cacgcatcat gacacagccg agtacaacta acggagccgt tgcgaaacca aattcttcgg 1838821 cgccgagcaa ggcagccatc acaacgtcgc ggcccgtcat gagctttcca tctgtttcta 1838881 atacaacacg gtcacgaagt ccgttcagca ttagtgtttg atgtgcttct gcaaggccaa 1838941 gctcccacgg aagccctgta tgtttaatac tggttttcgg agaagcgcct gtacctccgt 1839001 catagccgct gatcacaatg acatctgcag tcgctttggc aacacctgca gcgattgttc 1839061 ctacacctgc ttttgacacc agctttacgc tgattcttgc gtcacggttg gcatttttca 1839121 aatcgtggat cagctgggct aaatcctcaa tcgaataaat gtcatggtgt ggcggaggtg 1839181 agattaatcc gacacctggc gttgacccac ggacatcggc aacccatgga tataccttgt 1839241 tgccaggaag ctgcccgcct tcacccggct tagcaccttg agccatttta atctgcagct 1839301 catcagcatt gacgaggtaa tggcttttga caccaaaccg tccggatgca atttgtttga 1839361 tcgcacttct tctatcatcg ccgttctcat ctggaacaaa gcgtttggga tcttctccgc 1839421 cttcaccgct gttgcttttt cctccaagac ggttcattgc gattgctaaa gcttcgtgcg 1839481 cttccttact caaggacccg aatgacatcg cacccgtttt aaaacgtttg acaatcgatt 1839541 cagcggattc aacctcctcc aacttcaaag gcttgcggtt tccgtcaaat gcgaacaagt 1839601 tccgcaaaaa tccgatgcgt tcttcatcag ccgcttttgt atactgttta aacagattgt 1839661 aatcatttct gcggcacgcc cattgcaaag tatgaatcgt tttcggatta aacgcatgat 1839721 gctctccgcc atttctccat tggaagtcac ttcccggttc aagcgttttg ctgtaatcat 1839781 cctgatacgc ttcccggtgg cggcgctgtg cctcttctgc aattgtttgt aaatcgatgc 1839841 cgcctagctg tgatgcagta cctgagaaat agcggtcgat cacatcgcgg ctgattccta 1839901 ccgcctcaaa gatttgtgcg cctctgtagc tttgcacagt tgaaattccc atcttggaca 1839961 tcacttttac gacgccctca gtaatgcttt ttccatattt gctaaccgct tcttcatagc 1840021 tgatatccaa acggccttca tcaatttcct gcttgtaggt cgcataagcg agataagggt 1840081 taatcgcatc tgcgccataa ccgattaacg ctgcaaagtg atgcacttca cgtgcttctc 1840141 ccgattccac aataatgctg accttcgtac gcagcccttt gcggattaag tgctggtgca 1840201 gtgcgcttac tgccagaagc ggcggaattg gtgtcagtcg ttcgttcatc tttttgtctg 1840261 ataaaattaa caaacttacg ccttggctga tggctttctc tgcctgtgtg aacatgtcct 1840321 ttaaaccgcg ttcaagatcc tctgaaaaca gcacatcaat tttttggctt tttaaatcag 1840381 gatgaacaat cgttttcaat gcgtaaaact gttcattgga taaaacaggt gtatacagtt 1840441 taatccggcg aacatttcgt tcacttggat gaagaagatc gccttccgca ccgagccaag 1840501 tcatcgttga agtgacaagc tgctcacgaa tcgcgtcgat tggcgggttc gttacttgtg 1840561 caaacagctg tttaaagtag ttaaacagcg attgcgctcg gtcagaaagt acagcaagcg 1840621 gagcgtcatt ccccattgaa ccaaggggat ctttgccttc tttaataaca ggaattagat 1840681 acttttggat atcctcatat gtgtatccga atgccttctg gcgagtaaga agatcactaa 1840741 attgttcttc ttctcttgac tccggatcag gatttacttg tacaagctct tcttcaagcc 1840801 atttttggta cggatactca gttgcaattt gtgttttgac ttcctcatcg gagataatac 1840861 ggccttcttc caggtcgatt aaaagcattt tcccaggctc aaggcggttt ttatataaaa 1840921 cgttctcctg ttcaacttca ataacgccta cttcagatga gaaaataata taatcatctt 1840981 ttgtgacata ataacgggcc ggacggagac cgttccggtc aaggatcgcc ccgatttgtt 1841041 taccgtcagt aaatgaaata gctgtcggtc cgtcccaagg ctccatcagg gagctatggt 1841101 actcgtagaa cgcccttttt tccttggaca tatgcgtatt ttccgtccaa ggctctggaa 1841161 tgagcatcat tgccgtatgt gccggtttgc gtccagccat cacaaaaaac tcaaatgcgt 1841221 tatccaaaat ggaagagtca ctgccatcag cattgagaat cggcaaaatc ttgtttaagt 1841281 cctcaccgaa gctttcagaa acaaattgct gctcacgtgc tctcatccag ttgatatttc 1841341 cgcgaagggt gttaatttca ccgttgtgaa ccaaatagcg gttaggatgc gctctttccc 1841401 atgtagggaa tgtattggta ctgaagcgtg aatgaacaag cgcaaaagca gaaacgaatg 1841461 cttcgtcttg cagatcagaa taaaatgcat caacctgttc aggtgttaaa aggcctttgt 1841521 aaacaatggt ctggcttgaa agactggcaa aataaaaatc aagaccttcc gttactcccc 1841581 aattttcagc ctgtttacga atgacataca attttcgttc aaaagataaa ttgtccttta 1841641 gatcagaact tgcgccgata aatacctgac ggacaaacgg acagcttttt tgcgccactg 1841701 ttccgatttt tccgacattt acaggtacag ttctccatcc aagaacgact tggccttctt 1841761 gttcaattag tgcattgatt tgcttttcaa ttttttttct ttcatcttcc ttctgtgaga 1841821 aaaagaccat tcctaccccg taacgttctt tttctggcag attgatgttt ttgcactctt 1841881 ttctaaagaa agcatcaggg atttgaacca gtaagccggc tccgtctcct gtatccggat 1841941 cactgccttg ccctcctcta tggtctagct ggcaaagcat cttaagtcct tgtttgacaa 1842001 tgtcgtgagt ctgcttgccc tttaagtgtg catataggcc gattccgcat gcatcatgtt 1842061 caaattcagg acggtagaga ccttgagctt ttggcatttg attgtacgtc ataattcctc 1842121 tcccccgatc aatttccgat aataccggtc ataaaatcta acaactctat aatcattgta 1842181 ggttttcaaa acgatataaa caatatataa tttagatcaa aagaatctca aaatgagata 1842241 gatggatgtg agacaaacat ggagctgcgc caactgcgtt attttatgga ggtggctgaa 1842301 agagaacacg tttcagaagc cgctgatcat ttgcatgtgg cccaatcagc aatcagcaga 1842361 caaattgcca atcttgaaga agaattaaat gtgaccttat ttgagcgtga agggagaaat 1842421 atcaaactca cgccaatcgg aaaagaattt ttaattcatg tgaaaacggc gatgaaagcc 1842481 attgattatg cgaaagagca aattgatgag tatcttgacc cgcatcgcgg aacggtaaag 1842541 atcggctttc ctacaagcct cgccagccag cttttgccga ctgtcatttc agcgtttaaa 1842601 gaagaatatc cgcacgtcga atttttgctg cgccaaggct cctataagtt tctgattgaa 1842661 gctgtcagaa accgcgatat tgatctggcc ttattagggc cggtgccgac gaatttctct 1842721 gacataacgg gaaaaatatt atttactgaa aaaatttacg cgcttgttcc attaaatcat 1842781 ccgcttgcta aacaaaaaac ggttcattta atcgatttgc gcaacgacca atttgtattg 1842841 ttcccggaag gatttgtact tagagagatg gcaatcgata cttgcaaaca agcaggcttt 1842901 gctcctctcg tttccacgga gggtgaggat ttggatgcga tcaaagggtt agtgtccgca 1842961 ggaatgggcg ttacccttct gcctgaaagt acttttgctg aaacaacacc tcgttttact 1843021 gtgaaaattc caattgagtt ccctcaagta aaacggactg tcggaatcat taaaccgaaa 1843081 aatagagagc ttgcgccttc cgcgaatgat ttttatgagt ttgtcattca atttttctct 1843141 aagctggagc agtatcaata aaaaaaatga acccgagctt ctatatagaa gcttcgggtt 1843201 tttttctgca aattaattta caggtaaaga aaaatccaca tggcaaacaa atgcttcttg 1843261 atcaattaga gctctatttg tcagttcctt tttcttttcc ggttcttgaa gctgtacaga 1843321 agagtaattg acgattccaa ggccgatttc cgtccctttt gaatccatca gccgaacaac 1843381 tgaaccgctt ttgaatttcc ctttaatctt ctgtacaccg tctaggtata aactcgattg 1843441 tccgtttgtt atttttcgtg aacaatcatc tgataaaatc atttcacctt ccggaccgga 1843501 attaaaagcg atccattgct ccttttgatt caacggaagc gttccttctg cttcaaaata 1843561 ggtgccttcc gcctgttcat gaacggcgtg gtataaaata tcgccagcat ctgcctgacc 1843621 taggaaacct ttaatgccag acgccattac gattttaaac gcatcaagct tagagcgcat 1843681 gccgccggtg ccaacgatgc ttccagtgtc acctgcgcat gcttcgatgt caggtgttat 1843741 ttcactcacc cgctgtatct ttttcgcttc tggatttgtg cgcggattgc cgtcatataa 1843801 tccgtctata tctgataaaa tcacaagcat atctgcatca atcaatcctg cgacttttgc 1843861 tgcgagcgta tcattgtcgc caaacttgag ccgattgacg gtaactgtgt cattttcgtt 1843921 tatgatcggg atgatgccgc gctcgagcag tacattcatt gtattcctga cattgttgta 1843981 tcgatattca tcagaaaaat cgcttctcgt aattaaaatt tgggatgcga catagccgtg 1844041 tgccaaaaac agctttgaat aagcctccat tagcaatccc tggccgattg aagctgatgc 1844101 ttgtttttct ggaagcttct cgggcctttg gataaatccg agcttccgat atcccgccgc 1844161 cactgcgcct gaggaaacca aaatcacttc ataaccggcg tctttgagtt tgacgacctg 1844221 gtcgaccaac gcttctaatt ttcgaatgct gatttctcca tgaaggcttg ttaatgaact 1844281 gcttccaatc ttcacaacga ctcttttcat gcttgtatca ggcgtcactt tatcactcct 1844341 gatagcggcg ctgcagtttt ttcgatatct tcgctgattt cctttgaacg cttagccgca 1844401 tgctttattg cttgagaaat cgcttctccg ccgccgctct ttttcaaggc ttgcagcccc 1844461 gctgctgtcg ttccgttcgg tgacgtgata ttatctctta agatctcagg atgttctcct 1844521 gtttccatga gcatttttgc ggcacctaaa agtgtctgtg cgccgatgct tcgagataac 1844581 tgtttatcga ggcccgcttc ctcgcctgtc ttttcaatga attccattaa ataataaaaa 1844641 tacgcgggtc cgctgcctgc aattccggtg aatatatcca tttgattttc ttggattgta 1844701 tagacttcgc ccatgcatcc gagcaatgct tcggccagct tcttcaggtc ttccgacaca 1844761 tatttgccaa gggcaatagc tgttgcagaa gcgccaatca tactggaagt gttgggcatc 1844821 actctgacaa ccggctgttc attaagcaat gattgttcaa taaaagaggt agttatgccg 1844881 gcaaggaccg acaatattaa ttgatggggt tgaatacgtg attttagtga tgacagagcg 1844941 ttttcggcgt cttttggctt cattgccaaa atgagcacat ccatgtcttc aatacatagt 1845001 tggttcggca aggcgccttt aatgccatat tgaagttcaa gttcagttaa tcgctctgta 1845061 ttgctgcggt ttgtaacgca gatgttttgt ttcgggattt tgttggctcg aacgatacct 1845121 gatatcattc cttccgccat agatcctgct cctataaagg ctactttctt ttgatcaaag 1845181 atcggtaaca tctcctttgt tcgctttttt gttcgcattt tcacacgttt aaaatgttac 1845241 cacgtgagga aatgatgtca agtttgaagg ccattattga tttgtattgt ttcttttcga 1845301 caaatatgta taatgaaaag cagaaaacac ccggttcaca ctgctgcgcc gggtgtttgt 1845361 ttctattaaa aattatctga gagagctttt tcaatcagtt ttttacagcg atccagctct 1845421 accttcagct gttttttata tagcttggca gcttcgtaat ctttaaattg atagaggacg 1845481 acttcctgga gcttagcccc ttcttttttt actttaattt gttttagtat cccgtcatca 1845541 agaagctcat gcaaagaccg gtatacttct gtatgatttg gtttaaaacc aatctcttta 1845601 aattcagacc gaagtacttc aagcagcttt aacccataga gtctctcttg ctctgtcatc 1845661 gttatcatat aaagcttcaa aaatgcgcgc tgtttcacta aaaagcctgt tgaactcctt 1845721 ttttcttctt tcatcatatg cactccttct tctgtcactg acaacactat gtactaaata 1845781 ttcaattttc ttttattgtt ttccttcttt atattaaaga ctgatagtcc agttatttca 1845841 tgtttactga ttataggtgt agcggaaaaa ataaatttcg actgaacatt tggtacatag 1845901 ttttcttagt tctattatag cctgcattta ctgctatctt caatttaaac gattgccagg 1845961 gtttacatat ctcattttac cggtacggat ttcattcaaa taaaaaaacc tgtcgaaaga 1846021 caggttttca tttttaagga tttgttgacc ataatcccgc tgttttgatg aaaatacgag 1846081 gatctaattt cagttgtgcc accatgtact cagcaagatc ctcaggctgc ataacttttt 1846141 caggattacc gtctgttaag ttcaattcga tagacatatc actagcgaca gtgctcggcg 1846201 ttaacgcgct gactctgata ttatgttttc tcacttcttg cataagagac tctgttaacc 1846261 cgagaacggc aaatttagaa gcgctgtaag cacttgttac agcagctcct ctttggcccg 1846321 ctgtagatga aatattaatg atgtctccgg ctttgcgttc gatcatttcc ggaagcaccg 1846381 cgcgagtgac atggtacaca cccattaggt tgacttgaat aatattttcc cactcatcag 1846441 ctgacagatc taagaaaccg ccaaatttgc tgatgccggc attattaatg aggatatcga 1846501 tatcaccgag ctgttccttc acttgagcta cagcttggtt aacctgatcg gcatctttta 1846561 catctgcagc agcaaatgca gcttttacac caagcgcttt gacttcttca gccacttttt 1846621 ctacattagc ggaagtccgg ccaattaacc cgatattcac gccttctttg gcaagcgcca 1846681 gagcagtagc gcggccaatt cctctgcctc cgcctgtgat tagtgcagtt ttatgttgta 1846741 aactttgcaa ttgaagcacc ctttctttgt ttacatatgt acgatatcac attataagta 1846801 caatacatcc aatacgcaaa tcaaacgaac tgtgtaaata tcatttcttc tgattaaaaa 1846861 aacggataca gggtaatgac ataagaaaag gagtgaacat atgattatag tttatatcag 1846921 tcttgcagta ttagcagttt ctattatctt cttaggagtt accgtgatcc aaaacaagaa 1846981 aaaaatagac cccgcactaa aggagctttc ctctgttacg caggctatgc aaaaacaaat 1847041 cgaaggatta aaaacagaaa cagagctgct gacgcaaaaa caaaagaaga ttcagcagga 1847101 tgtccaaata aaaaaataca cgcttcagca gaccgcagct gaagtgaaag aagttcccca 1847161 agcagtcaaa gaggtgtggc aggcaggaca ttttaatagc agataaggat gaatgagatc 1847221 ccgttgttac gatcagaatg gacaaatggg atctcatttt tcgaggaggc ttacacatga 1847281 ttataaaccg cagctgctta aaagagttcg cagaaaaagt acattttctt ccctcttcac 1847341 ttacaaagtc cgatttactt actgatccat ttcgtctcca tcaagaaaac gaacttggca 1847401 tctactattc acctcataat gaatttatca atcgggatgc ctcgcttgtg attgccggga 1847461 tcacgcctgg tttttcccag atgaagacag cgtacgaaac agccgccgaa agcctgctgc 1847521 aaggcgggac tcttgagcaa atggcagtag acacaaaaat agcagcgggt ttctccggat 1847581 cgatgagaca taaccttatt accatgctgg atttatgcgg gctgccgcaa gcttttggca 1847641 ttcaaagcgc cgcaaagctt tttggagaat tacggcatat gctccataca acttccgtta 1847701 ttaaatatcc tgtctttatc cagcaaaaaa actataccgg atacaaaccg gctatcactc 1847761 attctcctat cctaagcact tatgcttttg ggcacttccc tgcagagctt aaccatgtga 1847821 cgggaccagc tcttctcatt ccgttaggaa aagcggccga aacagtgtgt gaaacattga 1847881 tcagacagca cagcctccag aatttgattt gccttaacgg ctttccccat ccatcaggcg 1847941 cgaacggcca tcgtttgaaa caattcagca aaaacaaaga gcaactagaa agacaaattc 1848001 gttcctttgc tgcattggtt gatttcgcta tagaaaagag gaaataaaag ggatatgata 1848061 aacaaaaaca caaacgtggg gagtggttga atgtttccta tattagaaac ggatcggctt 1848121 atacttaggc aaatcacaga tcaggatgcg gaagccattt ttgcttgttt ctcaaacgat 1848181 gaggtgacac gctattatgg gcttgaaaac atggaatcta tagaacaggc catttcaatg 1848241 attcaaacgt ttgctgccct ctatcaagaa aaacgcggta tacggtgggg aattgaaaga 1848301 cgggacacta aagaactgat cggaacaatt ggctttcacg ctctggccca aaagcatagg 1848361 cgcgcggaaa tcggttatga aatcatcccg gagcattggc gaaacggatt tgcatcagaa 1848421 gtcatttcaa aggtcgtatc ttacggattt tctgcccttg gactgtcgcg tattggcgca 1848481 gttgtattta ccgataatga agcatcaaat cgtctgcttc taaaaatggg gtttcaaaaa 1848541 gaaggcgttt taagacagta catgtatcaa aatgggactc catatgatac aaatgtgtac 1848601 tctattgtga aaccaagaga atgacggtat tctcttggtc tgtgccacat cccttttcct 1848661 ttaaaaagat aaaaagcgcc cctcaaacag ggcgctttct aattaagatg catattgagg 1848721 agatgtttcc tccttaactg ctttttcctc aggtatatga atacattttg tcaagaccgc 1848781 acttgcaagg taaagggccg caaagatcca gacgacacct tgcgcgccga cgagaccgat 1848841 gaacagccaa gcgagtgcag ggccgacaaa cgctgataaa cctgcagcta aattcaatac 1848901 agacatggct gcccctttat cttttcctgc caccgtcggc acaattgcac caatcggcac 1848961 atagcctgcc agcaaaccgc cccaaataaa gccgatcacg ctgacaaccg ctaaacttcc 1849021 gccggagaaa acaggtgcgt agtataataa gacggtgaaa atgccgcagc cgactccgcc 1849081 gaaccaaata acagtatttt tccagccgaa tttatcgccg acaataccga agataaggtt 1849141 aaacacaatg ttccccagga aaatcgttcc ccaaatttgc agccacacat tggttgaaat 1849201 tccatgctgg gccatgtgca tcggcaaaaa gactggaaaa ccatatgtac caatgctgtt 1849261 gatgattctg atgattccgc ctgtaagcac gcgcggattt gtaaatagaa tcgtaacccc 1849321 ttttaaaagc tcctcggctg tttctgatct ttttcttttc ttcttttcaa aacggtcttt 1849381 attgataaac aatgcaaaga atgcaccgag acatacccag aaaatagagc tccaaagcgt 1849441 attcaaataa ccgaacgctt tgatcgcgta gcttgagtac caagcgccga acacaaacat 1849501 gccgaggcaa tatgcaatcc aaaaccagcc gacagcagtg ctcagtttgc tttgcggtgt 1849561 tctgtaaatg acccatgtca agaaagaata agcaaaaagc gggtaaccta acccttttac 1849621 gaagtaagtc acatacatca ctggcaggtt cagctgttca aatccaaata cgataaaagc 1849681 agctgtaccg atcacataaa acaacagccc cataaacatc gttcgttttg cgccaaatgc 1849741 ttcgagacat acacccgaaa accaggaagc tatggcaagc gcaattccgt atatactaaa 1849801 aatggaagcg gactgctgaa cggtgagccc gttttcgatc aaaaaaggac tgagccagcc 1849861 ttgttcaagg ccatctccca tcataaacaa aacaacccct aaaaatcccc aggcaagccg 1849921 cttcggtatt cctattttat ccaacatatc tgtctcctcc ttagatgcta ttattcatta 1849981 ccgtattacc ttattaaagt tgaaaattaa atgattcctc aaaacagcag aaattccgtc 1850041 ttaaattaat actttgcttt ctgatcctga aaaaaagcgc tgtgtttgct tccattcctc 1850101 atataaagcc aattctatct gacagtcctt cggttcgatc acccggacat ttgctgacat 1850161 ctcctccgtt aattgaaagg tttcattgca aatgactgca gcaccgacga cagatgcctg 1850221 atgatatccc tcttggacat agaccttttt ttgaagaaga tccgcgatat attgagtgag 1850281 cgctttgctt tggaatcccc ctccgcacac ccaaacataa tcacgttcaa acggagtaac 1850341 ctctgttaaa atgtcaaagt tccatttgat tgaaaatgcg atctcttcta gcgctgcacg 1850401 tacaaaatgt gccctcttta aatgtgctga cagcggggca tcaaaaagaa aaccgcctct 1850461 cgttaacgca ttcttttcag ccgataaata agagccgaga gccgctacac atgcatggtc 1850521 ttcttttgca agtgcagaaa tctcctcctc cattacttcg tacgtttcat tcggataaaa 1850581 aatctgtttt aatttttgat aattcaagcc ggtaattccc ggattcgttt ccacaagcca 1850641 atgcccttga tccgtatgac agttcaacca ggctttatgt tttgtgtcgc catgatcctc 1850701 agtaattttg gttattggcg ttgttgtccc tgatacaatg acaatgtcct caagtccagc 1850761 tccggtgctt ttgacagcca gctgtgtatc cccgccccct gctataacct tagcatttat 1850821 tgaaaggcct aattcggatg catattcatt tgctatcgtt ccaattgctg ttcccgctct 1850881 tacaagaggc ggaaggatag atggagaaaa gccgaaaatg tcgcacatct cttctgacca 1850941 agtgttttgc ttcacatcaa atagcagggt ttctgttgcc tgtgatggtt catatgttaa 1851001 tattccgctc agttggtacg tcacccaatc actgatgctt gtaaagcttg cagtcttttc 1851061 ccataaagag ggctggcgct gttttaatcc ataaagcttg agcgcagaaa aaagtgcagt 1851121 tggcaggcgg cctgtgctgc tgtatatctc ttcccaatcg ggaatgcccg cctcccactc 1851181 tcggccgcga ttatcgatgt tcggcagccc gagaaaagga ttgccgtttt gatcaatcaa 1851241 aacaatcccc tgtctttggc tcgtcgatgt caaaccaatg atgtcaatat cacacgaacg 1851301 ggatagcgca cgttttgcca aattcatcac ctgcttccac agcacctgag gagaaaaata 1851361 acggctgtcc gggtaaagcg tctctgtgga atactcgatg tcctcccgtt caactgttag 1851421 aacactgcca gttacactca cgaccgctac cctcgcattg cctgtgccaa tatcaaaaac 1851481 gagatagcct ttttgttttt tcattctgtt agcctccttt cttatccccc tgttttcagt 1851541 gcgtccttgt tatacattgt ctgaatatta agagtttttt cacccttcca ctttttgagg 1851601 gctttattca gtatcgtcac gtgatgatcc tccacttcaa atgttgctcc agcgagatgc 1851661 ggtgttgcca gaacattagg caatgaaatc aattcataat ctgattcctc tggaggttca 1851721 tgataaaaaa cgtctagtat cgcaccgctg attttatgtt cttttaatac aaataaaaga 1851781 tcttcacggt ttacaacaac tgctcttgaa gtattaacga aaatcgcact ctctttcatc 1851841 agatcaaaat attgccgatc tatcagtccg agtgtttcct cagtgcgagg cagatggaca 1851901 gaaacgatat cgctgtctga aaacaccgtt ttaagagatg ctttttcata caacggatga 1851961 tcgtcttgaa tgtatggatc gtaatatttt atcttacagt caaacgcagt cagcagtttt 1852021 gcaatccttt gcccgactgc gccgaaccca atcatgccaa ccgtttttcc tgttagctca 1852081 tttcctttaa atttgacata agcctgcagg taatcactgt cccactctcc atccttcagc 1852141 cactgattcg aggcgctggt atggcgcaga aaggaaatca catttccaat aaacatttcg 1852201 gcaacggctt gtgcattccg ccctggtgta taaaaaacag gtatgcccct ttttgaggca 1852261 gctgccacat ccacatttga gggcattccc ctgcaaacac cgacaaatga aagttcggga 1852321 acagaagcaa atacgctgtc tgttacctga tcaagttcag taatcaagcc tgtcgcattt 1852381 gttgctttta gcagctgaat gagttcatcc tcccgatatg ccctaccttg ttccttccaa 1852441 gattgataag caactgagcc aaacaagttt tcaagctctt ttcgtccttc ttcgttgtac 1852501 ggtgctgtaa ccaaaaccgt catgctgcaa aacatccttt tcatcgtatt tttcataaaa 1852561 aaaatctctt tccgaagatg gaaagagatt catatatagg cgcgctctgt tacaggcaga 1852621 cgccggtata aaccttgctt tcctatcttt caagctagcg cttgctggaa ttggcacaat 1852681 aatgttgccg aggtttcata gggccagtcc ctccacctct ctggatagaa aatattgagt 1852741 atgtaatttt cagaatgaag aatacgttta tcataaagaa gactcagatt gatgtcaatc 1852801 tctttttttc agaattgacg ttatcatcgg aaatgttata attcttacaa aatatctaac 1852861 tagagagagg aactgggcca tgagatcttt tgccacacaa caaaacggca ttttcaaatc 1852921 cgtttgctcg ctggactgcc cggatcagtg cggattgtta atacataaaa aagacgggaa 1852981 aatcgtaaaa gtgcaaggag accctgatca tcctgtcaca gctggaaaca tatgcaacaa 1853041 agtccggaat atgacggagc gcatctatga tgaaaagcgg ctgactacac cgctcaaacg 1853101 aacaggtgcg aaaggccaag cgatatttga accgatttcc tggaaagagg caatcgatac 1853161 gatcacctcc cgctggaaac agctgattga tgaagaggga gctgaaagca tacttcctta 1853221 cagcttttac ggaaatatgg ggaaattgac agctgaagga atggaccgcc gcttttttta 1853281 ccgcatgggg tcaagccagc ttgaacggac gatttgcagc aaagcgggat ctgaaggcta 1853341 taaatataca atgggcataa gcgcgggaat cgatcctgag gaaaccgttc atacaaaact 1853401 atttattttt tggggaatca acgcggtcag cacaaatatg caccaaatta cgatcgccca 1853461 aaaagcgcga aaaaaaggtg ccaaaattgt cgtgatcgat gtgcataaaa atcaaacagg 1853521 acgtcttgca gattggttta tcccaataaa accgggaacc gacagtgcac ttgctcttgg 1853581 catcatgcac attttattta aagaaaacct tcatgatgaa gcatttctgt ccgagtacac 1853641 ggttggctat gaagagctcc gtgaacacgt gaaacaatat gatcctgaaa aggtatcgac 1853701 gatcaccggt gtcagtaccg aagatattta ccgactggca aaaatgtacg gggaaacctc 1853761 cccttctttt atcagaatcg gaaacggacc ccagcatcac gataacgggg ggatgattgt 1853821 aaggacgatt gcctgtcttc cggcgatcac cggccaatgg ctgcacacag ggggcggcgc 1853881 aattaagcat aacagcggaa ttttagaata taacacaaat gccttgcagc ggcccgactt 1853941 attgaaaggg cgcaccccga ggtcgtttaa tatgaatcag cttggcaggg tgcttttgga 1854001 aacagacccg ccgattcgct ctctatttat ttacggaacg aaccctgccg tcgtcgcgcc 1854061 cgaagcaaac aaagtcagac agggcttgct gcgggaagac ttgtttactg tggttcatga 1854121 tttgttttta acggaaacgg ctgcatatgc ggacattgta ctgcctgcaa catccgcttt 1854181 tgaaaatact gatttttaca cctcctactg gcaccattac attcagcttc agcagccggt 1854241 gattgagaga tatggggaaa gcaagtctaa cactgaggtt ttccgattac tggctgaagc 1854301 catgggattc acagaccagg agcttaaaga ttcagatgaa gtattaatcc gccaggcgct 1854361 tgaccatcca gataatccgc atttggcaga gattgattac gattcactta ctaagcattc 1854421 atttatgaaa gcgaaacgtg aaaagccgct gtttccgggc gaacttccaa cgccaagcgg 1854481 aaaaatagaa ttatattcag aaaaaatgaa acaagacggc ttccctgctt taccgacata 1854541 tacacctctt gtaaccgata atgaacatcc gtttatgtat gttccggggc caaaccataa 1854601 tttcttaaac tcaacatttt ccaataatga aaaacacatc aagcttgaaa agacgccaaa 1854661 gctctttatc aacacaaaag atgctgaaaa acacggaatc gttgatgggg cacctgtacg 1854721 aatttggaac agccggggag aatgcgagct gaccgctgca gttggagaac aagtgctgcc 1854781 aggtgtcgtt gtcagccaag gattatgggc ggatgaacaa ggaaaaaaac agcttgtaaa 1854841 cgcgctaacc ccagatcgct tgtccgatat gggcggcggc gccacctttt tttcaggccg 1854901 tgtacagatt gaaaaggttt gaaaaataat gaaacccgga gtatgccaag cccgtataac 1854961 ataacatcga cataatggag gcatacacat ggacgttttt ttaggaattg gtattgcttt 1855021 ggctggatat tttatcggtg aaggcttaaa gcagaggaac caaaccaaag gtaatgaaca 1855081 aaatgatatc ttcctaataa aagaacggga tatttacttt tacattggac tttttttagg 1855141 aataacaacg actgaagcaa aacagttagc tggagacatg gcagacctgc cttacatcga 1855201 aataaacgga aaaaaatatg tccagaaaca tatgttaaaa gattggacat tcacattagt 1855261 tgaaaaacat cagggtgaat aaaacaaatc tgaggagagc gagattcatt gtcacgctct 1855321 cctctgttta gctgtatgga tcctgccacc aaaactttgt gctataagcg ctgataaaac 1855381 gataaaccac catctatgtt ctttcctcaa acaactcaag atgcccgttc cacaacaata 1855441 gtttttatat tcctttgatg acgtgatgtt cttgatgaac gtatgtatcg taaaacactt 1855501 agaaaaccta ttcggtttga atgtgtgctc tcattatgcc cccatactgc gcctttatcc 1855561 gcggaggatt tttttaaaaa aatatgaaac ctaaagcttt tagatcctga atttttattg 1855621 aacctccata tttctccgat tggtaaaaat tagcctatac accggaagct gtacgtttat 1855681 aaaggatcag agaatcccat aaccagtaaa tcactgcagc cgcaatactt aacatataat 1855741 aaaagtacga ttgcaatgtc catgctattg acgcaggttc attgataaca aaaaacagga 1855801 aagctgcgat aaaagcaacc acactgtaaa tcaataggta catgacattg aaagttctcg 1855861 cttttttctg caacttcatt tggagcggaa cagcaaaaag gccatacacc acaaaaccgt 1855921 ataataaagc aattgctgcc gtaaacaatg caattatcat atcgccatac ataacgaaag 1855981 aataaaaccc taataacaaa ccaaatgtaa ggctggatag ccctaatgtc attaaataat 1856041 atgatgcgat ttttttcatt ttttcacccc ccttgtttga tttattcaca gtgctgttag 1856101 tataaattca caacctttgt atttctttta tcgagatgtc ttccctaacg tgctatacgc 1856161 aatgcgctaa taaaaggttt caaaaatgac gttcttttat tagataatac gctggctgaa 1856221 aacgcctctc ctgattggcc aaagcgcgaa tgaaaaaagt gcatgaatac ctgcccaaca 1856281 gacagaataa gaagagttga tatttcaaca cttttcgtaa aggggtgaaa ccaatgagta 1856341 agaaaggtat tcaaaattca agtattgaac aaataagaaa tgaccatgag actgaaacag 1856401 cttttaaagc agatgatcct aaaaaacacg gttccgatcc taaaagaacg aaataagttc 1856461 ttacccccac taaaatatca ataatctgga ggaagtaaag tgactcaaaa aaacggtgca 1856521 gacagacctg atgattataa aagattttct tcattagaca aggaatatga ttttcagcaa 1856581 tctatacgca gcaatactga gacagaaagt gtaaacactg aaacacaaac tcataacaaa 1856641 gaaaacaaaa atgacacaac agatgttgcc gggaaatact ttgagccctc agattataaa 1856701 ggaagcacgc aattagaaaa aggattggct gaaactcatg aacaggtcag cgatgactat 1856761 tttgaaggga caatcgatca aaatttggac tagccataca aacggaacta acttaaaaga 1856821 agtcagttaa ctctgttttt agaaacaacc acagtaaaag tagccaaccc ccaccgaata 1856881 agatgggggt tgcacgtaag tagcctgttt aatatttaaa acgattaatg acggtttgaa 1856941 gttcttctgc caactgagat agagattctg cggcatagga gatttccccc attgaatgaa 1857001 gctgttcctg tgatgaattt gcaaccgctt ctgtatttgc tgacgtttct tttgtaccag 1857061 cagccaatgt atgaactgtg tgctgaatca cttcaacgcc tgaagtaagc tgttgagttg 1857121 ctgctgcaac ttcttgtatt tgagaagtga cctgttccac caggttcagt atttcattga 1857181 aatttcctgt tgtctcttga gaaagaacaa tacctgagct cacattttct tgaacaactt 1857241 taatattatt taccgtttct atcgattcgt tttggatggt cgctaccacc gattggatgt 1857301 ggtttgcaga tttatttgtt tcatccgcca acttccgaac ttcttctgcc accacagcaa 1857361 atccttttcc ttgctctccg gctctggccg cctcgatcgc tgcatttagt gccaacaaat 1857421 ttgtctgctc tgaaatcgtc gtgataagcg aagagatatc gctgatttct gctgtgctcg 1857481 ctaccaatgt ttgcaatcca ttgccggctg aatctacaga tttatcaatg aatttcatct 1857541 ggtctaacat cttgttgacg gacttagagc ctatttcagc cttgtctctc atcgaagaag 1857601 aaagatccgc tatgttccct gtatttgaag cgactgatga tatactgtct aataattcag 1857661 tgatggattc tgcgctcttt tctgtcattg agctttgctt cacattgctg tcggcagcca 1857721 tctgcatggc tcgtgaaata tgttcagatg ttgatttcga ttcttccgcg cttgccgata 1857781 attcttcaga ggaagcggcg acttgttcag atgagctgct gatctgcttc acaatttgag 1857841 ttaatgaatg agtaaaagaa ttaaaagatt gggcaagctg gccaaattca tctttatttt 1857901 tcacaatgac ttttttggtt aaatcagcct cgccgtgtgc aatttcctcc agctgcttat 1857961 ttatgcttct tagtggcacc ataatggact ttaacagcat tatgcttaga acaatgccta 1858021 atattactga tatccctgtg acaatgataa tgagcgattg actcattttc ccattgccct 1858081 gtatttcatc ctttagatcc tctacctctt gatccaggcg atcagacagc ttattgacag 1858141 ccggagctac gccttctttt cttattgttc tttcttctcc aaaatggatg gtttctgctt 1858201 ttttaggatt tgaagagtag gctgttacta cttgctgatt caaagctcta tactgagtaa 1858261 aacttgtctt aatgtcttca atattggatt gatacttctc ttcatcaatc aagtcattaa 1858321 cccggtcaag gctctttaag acatcgtctg cttttccctt cataccctcg tcgtattctt 1858381 tgtctctggt aatcaagaag cctctttcat catttgataa cccggtcaat tcatattgga 1858441 tgtgttttat ctctttttgg aattccattt tgtctttaag ttcttcattc tttttcacag 1858501 tagaagaaat cataaatact gaggagcctc caattccaat aattgaaaca actaatattg 1858561 atataatccc cagcaatttt gttttcactt tcatgtgtcg ttttcccttt ccgcacaatg 1858621 taatggctga aataaaatat gttcaagcgc gtttgaatcc aattcgctta cgctcatgtc 1858681 cataatatcg acacgtgtta tcaagtttta tagtgatatt cttatatgaa taagcaaatt 1858741 ctttacgtct ctgaacttac agaaaaacct taagtaaaat ttgcagtctt ttgcggtatg 1858801 taagtcactc ttattcgttt ttctaaaaaa ggcttttccc acctcaaatt ggctgaaccg 1858861 gctgttttct cgaaaatata atacaatacg cagcataata tgaaggagcg aaacttaaat 1858921 ggggatcatc aatggtaaag aattcattga ccgattgaat aaactagaaa acgaaatatg 1858981 gtatgatggc gaaaaaataa agggtaacat ttctgagcat cctgcattta aaggaataat 1859041 caaaacaaaa agctcacttt atgaattgca aacaaaggat gagttaatac atgaaatgac 1859101 ttattgcctt cctggagatc ataatcgaat cggcctttcc tatctccagc ctaaaacaaa 1859161 aaatgatttg aaaaaaagaa ggaccatgat tgaacattgg gctagacata ctcatggaat 1859221 gatggggaga agtccggatt acatgaatac ggttatgatg agctttgctt cgtcagcgga 1859281 gcttctaaaa gataaagaga attgctttcc tgaacatata ctagatatgt atgaacaagc 1859341 tgctaagcat gacctttcct ttacccatac attcattact ccgcaagtga accggtcaca 1859401 gtcctatttt gggctaagtg aaaaaccgat atctgctaaa gtcattgata gaaccgaaaa 1859461 aggtttaatg attcatggcg cacgactgct tgccacacaa ggcgggttga ccgatgaaat 1859521 cttggttttt tcagcgccta aatttttctt tgaaacagat gaagcttatg ctttttcaat 1859581 cccttctaat acaaaaggcg taaaattcat cacaagagaa tcatttgtat taagcgactc 1859641 ttcctttaat catcccttaa gctcaaggta tgaagaaatg gattcaattg tggtttttga 1859701 tcatgtgtta gtgccgtgga atcgtgtgtt tttttacgat aatgtggaag cagctaaaga 1859761 ttttatgaca aaaagctctt ttcatgcctt tacctttcac caggttgtca ttaggcaaat 1859821 gataaaaatt gaatttctat taggtgttgc acagcttctt gtcgacacca ttaatgtttc 1859881 cgaatatcag cacatccaag aaaagctctc agaaatcatt gtgggattgg aaacaatcaa 1859941 agccctcatt gacaaatcgg aaaatgatgc tcagttagat gaattcggct atatgcgccc 1860001 ctgtttaatt cctcttcaag tcatcagtac gatcattcct aagctatatc ctcgatttac 1860061 tgaaatcata caattaattg gagctagcgg aatggtgaca ctgcctaccg aaaatgcatt 1860121 tgactcagag atacgggaag atcttgacca atatcttcaa gcaaccaata caaatgctga 1860181 agaacgtgtg aaaattttcc gtttggcatg ggatttaaca atgagttcat tcggaactag 1860241 acaaactcac tacgaaagat attttttcgg agatcctatt cggatttcaa gcaggctgta 1860301 taccagttat ccaaagcagg agcagttgaa catgattaaa acatttttac atgcagatac 1860361 agaacattga aaaaacagcg ggaaaagatc cgctgtttcg tattttttat tcaggaaact 1860421 gaacatggcc cggtactgta taggctttgg acgttccgct ttcaggcagc tttggaatgg 1860481 tgtctttcac aacttttccg cggatgtcag tcattctgac tttgagagag ccagtaccta 1860541 aattcgtact cacaaaatgg ttatagtcca ttttctccat gttgatccac ttaccatcct 1860601 tttcatattc cattttcata acaggatact tgtgatttct gacttggatt gctgcccacc 1860661 acctgctgct gccttctttg atccggtacg tgaaattgcc ggtgattggg gctttgacaa 1860721 cacgccattt aatattgatt tttccgtctt tcatattgcc gattttacgg aaggcattag 1860781 gtgacagatc aagagctccc cgagcgcctt cgggataaag atcagtaaca tatacggttg 1860841 ttttcccttt tggcccttca acttccaaat aagagccggc aagtgccgct tttactcctc 1860901 cgtaattgag atccgccgga tttattgcag taatctccat atcggaagga atgggatcca 1860961 gcaggaaagc tcctcctgaa tagcctgacc ctgtatacgt tgcataacct tcatgcaggt 1861021 cgtcatatgc tgccgaagct tgcggggaaa aacagaagat cgtcaacaaa accataccaa 1861081 caaatgcact catgatcttt ttcatatttg gtcctcctca aaccagactt caaatgagaa 1861141 tcattatcat tataagactc aatccatctg gtttgaaaga ggaaatagat tcatagttga 1861201 ttttaaggca aattcactat cattcatata tcaaatgtag gtacttatga aaaagccaat 1861261 acaaatgaac gaatgtgcac ttcagccgaa tgtcttattt ttccctctca aaattcgcat 1861321 ttcaataacg aaatgaaaca ggctgttggc ctgataacag ctatacagga aaagctattt 1861381 ttccccgctc agtttcaact tagctgtcat catgatgcca aagatcagca caatcggaac 1861441 ccaaataatg aagtgataaa aatcaggctc agccagagca acaataatag cccctacaca 1861501 atacaaaata atagccagtg ctcttaacac agtatctctt aagaaagtct tcttttgctt 1861561 cttaaaaaac aaacggccgg atatatcctc taaaagagaa gccaaagtgc cggtcaacac 1861621 agttgaagaa atacctgcaa tccccagttt ttttgctgct gtagtttgaa tccccataga 1861681 aatgctcatg agtataatta gaatgtgcac aggaacaaat gcccggtaaa aagaaagaca 1861741 agcaaagaca aacaaaatga atgcttcaag tgcgagggct tttgtcacag cagaaggcca 1861801 aagggtattt tccgcctttc cgaccatcaa tgtagcaatg atcacgccgc atataaatcc 1861861 gattagcgca gtcaaggaat taaaaacagt gacctgaatg gatttgccga tagctaaccc 1861921 caataataca atgtttccag tcatattagc tgtgaacaca tgtcccaggc ttaaataccc 1861981 gattacatcc acgattccag ctgttaaaca taaaagtgat agcaaggtgt ttcgataagc 1862041 tgctgcagtc aacggtgtat caatcctttc ttctatttca attgttagta tgtcttttgg 1862101 cgcaatctct attttttaag taacccaaca ttaattagga agatagaacc tattattcct 1862161 ttccattaac tgtaataata atccccgcaa ggaaatgatt aaaattgaaa ggaagcatat 1862221 tgtgatgaaa cgactttgtt tatggttcac cgtctttagc ttgtttttgg ttctcttgcc 1862281 tggaaaagca ttaggtgcag tcgattttcc gaatacctca acaaatggcc ttttaggttt 1862341 tgccggaaat gccaaaaatg aaaaaggcat ctctaaaacg ggcacaacgg gtggaaaaaa 1862401 cgggcagatt gtttacattc aaagcgtaaa tgatttaaaa acccatctag gaggatccac 1862461 tccgaaaatt ttagtgcttc aaaatgatct ttccgcatct gcgaaaacaa cagttaccat 1862521 tggctcaaat aaaacactcg tgggctctta cgcgaaaaaa acgctgaaaa atatttattt 1862581 aacaacttca tcagcttttg gaaatgtcat ttttcaaaat ttaacgtttg aacacagtcc 1862641 gcagattaac ggaaataatg atatccagct ttatttagat tccggtatga actattggat 1862701 tgatcacgtc acattctcag gtcatagcta taatgcaagc ggaagcgatt tggacaaact 1862761 cgtgtatatc ggaaaatccg cagattatat cacgatcagc aactcaaaat ttgcgaatca 1862821 taaatacggt ttgattttag gatacccgga tgattctcag catcaatatg acggctaccc 1862881 ccacatgaca atcgccaata attattttga gaacttgtat gttagaggcc caggtctgat 1862941 gagatacggt tactttcatg ttaaaaacaa ttacagcaat aattttaacc aggcgattac 1863001 aattgctaca aaagcaaaaa tatattccga atataattac tttgggaaag gcagtgaaaa 1863061 aggcggcatc cttgacgaca agggcactgg ttatttcaaa gacataggca gctatccatc 1863121 actcaacaag caaacctctc cgctgacttc ttggaatcct gggtcaaact atagctatcg 1863181 tgtccaaacg ccggaatata caaaagaatt tgtcacgaaa tatgccggat cacaaagtac 1863241 aactctggta tttggctact gatataaaag aggccctgcg ttaaaaacgc tgtgcctctt 1863301 tttatactat aggctatttt taagcgatcc ttgtaattcc atcaagatcc agcgtcggtc 1863361 aaactaaaaa gcatatgttc ttttccacaa taacttctta actggctttc ttattatacc 1863421 agtttatcgc aagtgaaaag aaatcattgt tctgaacctg tattaaatga acgatcgtcc 1863481 cacaaactac ttaaaaaccc ctaaaaagga tgatggatat gtgcggcagg tttactttgt 1863541 actctgcatt tgatgatatt attgaccagt ttgacatcga tcaatttttt cctaaaggtg 1863601 aataccagcc aagctataat gtcgcaccat cacaaaacat ccttgcaatc atcaatgatg 1863661 gatcaaataa tcgcttaggc aagcttagat ggggacttat tccaccttgg gcaaaagatg 1863721 aaaagatcgg ttataaaatg atcaatgctc gagccgaaac aattaccgag aaaccggcct 1863781 ttcgaagacc gcttgtcagc aaacgctgca tcataccagc agacagtttt tatgaatgga 1863841 aacggcttga ttccaaaacc aaaatcccaa tgcggatcaa attgaaatca tctgctcttt 1863901 ttgcgtttgc tggcttatat gaaaagtgga gcacacatca aggataccct ctttatacct 1863961 gcaccatcat aacaactgag cctaatgagt tcatgaaaga tatacacgac cgaatgccgg 1864021 ttatattggc ccatgatcat gaaaaggagt ggcttaaccc caaaaataca agccctgatt 1864081 atctgcaaag tttgctgctg ccttatgatg ctgatgacat ggaagcatac caggtttcat 1864141 cattagtaaa ttcacccaaa aataattcag ctgagcttct tgatgcagaa aatcatatgt 1864201 agtgattgaa aaaattctct agcaagaact tgtcaaatag ctttgttcct taggtgccaa 1864261 tccctctagt aattatgaat atttagtaca tagatcaatt agttatcttt agcatcagtt 1864321 tgaaataatt ttattatgta aacttaaata agcaatgtta ttcctttcat ataaaatagt 1864381 ttacattttt ataaaatcgc ttcacttttc tattttgtca gcaaaaaaac tgaaccacat 1864441 taaacttatg aaacctgccg cacctgtgga ttgcaaatat gatataagcc catagaggta 1864501 aatccataca ctttccctcc taagaattaa atgaaatttc tttcatctta catgaaggtc 1864561 ttctttcttt tgtttatcca gtgtaatact taataatatg ttgatgaatg cagctggaaa 1864621 atatataaat cccactccaa gaatgcctag tatcgtactt aaacttacta tgtaattctt 1864681 tgtcatcgtt tgactgtcaa tcaatattag aagtgaaatc aatccagcta aaacacctat 1864741 aaaccaagca tcgccaacag cataagaatc atccagcatc cctaaccatc gccccaatat 1864801 agagctccca atggcagtca aactggataa aaatatgagt gctttcattt cttctcctcc 1864861 tttaaagcca atcaaactgg tagaaatcgg ccattgaatc cccattatcg aatggttacc 1864921 atttcatttc cacattaaca ttttaaagct cattacaata cgattcaagc agaaaaaccc 1864981 tacataacgt atatataggg atttaataaa acacaggcca aaattcagct ctatctactt 1865041 taaaaagata tgaagggcag ctgtgtgatc tgttacgtct ttacgtaccg ggatatttca 1865101 caacaggcac tttcttcttg cgcagagaat caagcatgac tgatccagca ttcaagttgc 1865161 tttgtactaa ttctttaggc gtcaatgcca tccactgatt gagtgacaca tctgcatagc 1865221 ggttactttt gaacatttct aaaaaccata atgtttctgt accagtgttt tgtatatagt 1865281 gtccggcatt agaaggcacg tatccaacgt cgcctgctct ataatcaaat gtgcgggcag 1865341 tcccatttcc gataaatacc gtcattcgtc cctgtcctgt tagataatat tgccactcat 1865401 cgctattggg atgccaatga agctctctca tcgcgccagg ctcaatctga acaagtgcag 1865461 cggctatcgt ttttgaaatt gggaagttag aagaatccac aattcgtaca ctcccccctg 1865521 gcatttgaat tgggggttga tttaacagct cgtgtttaaa ggtcatgggg acttttccat 1865581 atggtgactg aatgtcttca ctggcgactg atcccggcac attcccttgg tagatataga 1865641 cttgctcaga cggaagagag ttgaaagcat tctccgggac accgaaattt gcagacagaa 1865701 catcttttgg tgtgtgtgca agccaatctg aaatggttaa cgttgaaaac tcagaaaagt 1865761 tcccatcatc gaaaacgagc agaaactcgc agtgttccaa tccctgtatg gaatgcggaa 1865821 ttcctgccgg gaagtaccaa aggtcgccgg gaccaacatc agcaatgaaa tttcgtccgt 1865881 cttggtcaac agcggtgata cgtgcccgtc ccaaaagcat ataagcccac tccgcttgct 1865941 tatgccaatg aagctcgcgg acgcctcccg cagttaagct catgtttaca cctgcaatcg 1866001 cagtcgaaat cggaagctgt cttacggtga tttctcttga ccagccgccg tgatctaatt 1866061 tcatgggagc gtctgagaat gaaaatctca agttaggaat cataccctca tctgtaacag 1866121 gcggaacaaa tatattcgga ttttgaatat cccgtattat atttcgcggg cctgtatcaa 1866181 tagctccagc tccatcactt cgaataggct gcggcacgtt tctgtcttca tgattgattg 1866241 gttgttgttc caacagcatg cacctcgttt tagaaatgaa caagatttta tttcagccta 1866301 tgcagaatct tagattgctg tgcctaggaa tccgcaaata aaaaagtgac caccaatgtg 1866361 atcacaaata catcaaataa actatttttt ataccatggc ttcttatgta atttgattgc 1866421 ttctgtctgt tttttctggc ctgtcctcca ctccactttt actaatacat catgacctat 1866481 cacttcatct tcaggcatat aatcaaaggt ggaaatatgg tcctccatgc gtcccccacc 1866541 cggcatttca tcacctgtgt actccgataa gtcgtactca tctacgttat catcttgata 1866601 cttttcgcca tctacataca gagtaattct ttcaacaaca gtccactttt cttccttctt 1866661 actcccctgc caatatagat ttagaaaata attgggtcca attgaagttt tgtctgattt 1866721 ttcaaggtta gacatccaca gtccgctttt cccgctgccc tcatatttca ctttgttccc 1866781 tgacaccatt acaaataatg tgatgatgca gatgatcaag aatccagcaa tgatcaatag 1866841 ccatttctta atattgttct tttttctcat gtttttcctc actttcctaa ctttttagta 1866901 ggaaaatacg atcaaaatgt taccgaaaag aaaataagaa agggctaatg atctaacaga 1866961 tgactgtcta aacttttgac ttaaattaaa gtgctttcta aagacaagat taaaacgtat 1867021 aacagctctt aaatgcattt tttgtttcat tgagtcaaga accttaaaat ggctttttat 1867081 tattaaaaat caagctagtg tattaagtaa cttttcaaat ttatttatac tcatgatctc 1867141 gtgagtcaca aatctcccat caaaaaaaac gctaaaagtt gtccaaatag ctggtgactt 1867201 ttgtgcctct tctttcgatg ataactgaat tgactgaaat tgaacccctt tcttttcagt 1867261 caattcccgc aaatcattta tcatgcccac tgcaaacgga cactgagctg tatagtatat 1867321 cgtaatcccc ttttcattga tagaatcact tttcacctgg ctcttaaatg caggagaatc 1867381 tgcaaggcca ttccaagtca aagccattaa ttgaaaataa ggggcagctt catcttgtag 1867441 agtaaacccc atatgctcaa agaaatgctt atcacttaaa tagggcagtt ttttcttgcc 1867501 tgcgatatgg ataatgccat ccatgccgca cgctttcgca tctgctatac atttgtccaa 1867561 caatcgtttc gcatgaccgt tatttttata tctgccagac acccacagac aattaatgta 1867621 cataaaatta ggcgcattga taggcaccca tgcctcattc gcaggtaggt attcaataaa 1867681 gacttttgcc cgttcatgta agcgatagaa caccaatcct tcatccattc gagctttgag 1867741 ccatctcttc ttttcattaa ctgcatgctc atattgtttc gtgcttaatg cacagcaaat 1867801 atgattgtct tcaatattgt cctttgtgat ttcaatgtag cacatctcct ctttcccccc 1867861 tttaacataa ttacatggaa ttcaacttca cactttacat gcctaataga ataaataccc 1867921 gttccaactt aaatactttt tcttttccat tttgccaatt aactgtaaaa cccttctttt 1867981 attcagatat tatcttgatt cctatatcac ccatttcaaa tccaaagtgt gttcatcttt 1868041 gaggattaga tgcactgctt atgctataaa tacagtacac gaagtttttt atttgaagta 1868101 atatttgtta cgggacagca atagtaaata agtgataaaa ggggaattaa acttggtgga 1868161 aaaatgttat tcttgtttaa tttgcggata caaaggatta attcaaaatc ctttgtataa 1868221 aggcgagtat caaaaaacgt ttgacatttg tccatgttgc ggttttgaat ttggctacag 1868281 tgaggatcat gatgtgaggt taggttttat tgtaactcct gatcatttaa ttgaggctgc 1868341 atttcaattg tatcgcaaac aatggcttga gagcgggatg gtaattgctc atccggaaga 1868401 tattccagaa gaattgaaaa atggcaattg cttaaaattt gaagttttgt tgaaacaatt 1868461 gaaaaaacta aatcttgaca tagaaaattt tgaaattagc ggtttttaat gatgaaacag 1868521 gttgcacttg tttaggtttc actgtcatta tcagtaaaat gttaagttga aatgcgcaat 1868581 cagtcacaaa gtctctattc gtattcaata aagactttgt gatcatcgac aaacatttca 1868641 ctcccatcgg ataaagtatc caaaaggcct cctctggttc ttctctatag tcattaatca 1868701 cagtcacttt gacatttgac tcagctatga ttggttttcc aacaattttt cgttttttcc 1868761 tcaggcaaag taagagatcg aatcatcaaa gccattccat ctttactgtc taattaacgc 1868821 catcttcagt gaatttaaag gtctgtttta aattgcgtcc ttcttgcccc ttctgtgtcc 1868881 aaattataac aacctctaat tcagaggcct tatctgccag cataaaatga ttgaacttca 1868941 gcggtgagcc atcatttaaa ctttcagcta acattttaga atcttctttt ggtttgacac 1869001 aattttcatc gggacatcca aaaagcgaaa accttgtgat tgaattaggg tcatttctat 1869061 acaattgcac atccactgta gctgcttttt cccctatatt tttgacttcc aaggaatata 1869121 cttgatattc tcctttatga ggtctcgtaa attcctttac attttttgct tcacttactt 1869181 ttactgacca ctggtctgtt ttttgtgtaa taggcaacac cgtaaaagtc agggcatgcg 1869241 cttttgattg gcaaaacgta aatccaactg ctgtaaaaac aattacagaa aataataccc 1869301 ttttcacttc atttatccct ccttcctttc actggccgct ccttaaagaa ttgattttga 1869361 gcaatctaca agctctctta accaaaacct tacctgaggt tttgtcttta ctgctctgca 1869421 tttatttctt tcggtatccg agaaggagct ttggggattt ttctcaatct gctgttaatc 1869481 acatcagaag agtatagcgt aataatcata cttcccccat acctttttgc ccgaattaag 1869541 attggttggt tatattggtt ttgaaagcga aagtcaggac ctccccagct taccgtcgca 1869601 tcccgtccgg gcggtacata tggtacactt ctagtatgag aatagcgctg aacgatctgc 1869661 agtcctgcac gatctactgc attaaataga gttgaggaca cctgacaaat tcctcctcct 1869721 acaccttcag acaactcccc ttttacaata atgggtgcac ttttatatcc tttgttccga 1869781 gttctcattc ccacaacttg gttaaacgaa aacgtctcat tagggaaaac aacgtgattg 1869841 tcgattgctt ttgcagaaag agaaatattg tgtgaacggc ttttattgct tgagttaaaa 1869901 tacgtcacgt actgaccaag ctgctgcgta ctgatgtgag ctagcagctc gctgtcaact 1869961 ttcggataaa tgttcatttc cggcacttct atcttggagg gaccttgccc ataaaaatac 1870021 gcataaaact tttccataaa cgcctgttga tacagtttgt agccaaccct gcccgggacg 1870081 atgcttccat gatcgttaag gacagcattt atcggctcac ggtacacttt ctgatcaagc 1870141 tgtttgatga atttactgta tttttcatag tcaaccattg gagtgccggg aagaggcatt 1870201 gtaaagtctt cacggttaac agtggcaatc gtccgtcctt gctgtgtgac cgttaaactg 1870261 tcctgcggct cactcggctg agccaataaa aaaagaccag tgatcaaaat ttgtatcata 1870321 agtcggttta cctcccaatc attagtatga acagccgctt atcctttgat gtatttcttc 1870381 ccatcgtttg tttgaatctt tagacgttga taaaaacctt cataaaagag cttagcttta 1870441 tgttcacacc gatccctgag ctcactgagg cacacggttc attcagtcgg caagtttgaa 1870501 gtagttcagc atctcccagt gatgagggat gcttttttgt cttgtcaaaa atgaaaaggg 1870561 tctcctataa caacaaaaaa tcaatccatt tcaatatttt tttattgaga aacgataaat 1870621 tttttgttac attcaattag acaacaaata aatgaggtgc ttgttatgaa tcgaatgtcg 1870681 acaatttttt taaagatagc tttggttctt attggaattc caattcttgc tttatgcatt 1870741 tttttagtgc ctaaggtagc caactattca gcagaattat ttccaaatat cgcttatata 1870801 aaatatctcg ttttcatcta tttgtatgta acggcgatac ctttttactt tgctctttat 1870861 caagcgttca aacttttaag ctatattgac aaaaacaaag ctttctcggg tttgtctgta 1870921 agagctttga agaatataaa atattgcgca gtcactatca gtatctttta cgcagcaggc 1870981 atgcctgtct tttatctgat ggccgagata gacgacgccc cgggtatcat tgtgatcgga 1871041 ttggttatta tttttgcttc aatggtgatt gcggtctttg ctgctgttct tcaaaaactg 1871101 ttaaaagaag cgattgatat aaaatcagaa aatgacttaa cggtctgagg tgatgacatg 1871161 gcgattatta tcaacattga tgtgatgctt gctaagagga aaatgagcgt aacagagctt 1871221 tcagagagag ttggcatcac catggctaat ctttcgatat taaaaaacgg aaaagcaaag 1871281 gctattcgat tatcaacttt agaagcgatt tgcaaggctt tagaatgtca gcccggggat 1871341 atattggaat accgaagtga tgaagacaca ggattcgtaa agaaaaaata tgaaggatca 1871401 acagaaaaat aaagtgattg gcggtgagct tatggacata aacttatatc catctagctg 1871461 ctatactaag cgtccctttc atacacgaag aacacaacta tggaggaggc atacatcatg 1871521 agagccataa aacaaatcgt ccattttggc tgggaacaag ccctttcatg tttgtttcct 1871581 gccgttattt ttgcctcttt ggctattacg caaatcatcc cactgccctt cttgccgcgg 1871641 tatgactggc tgctcattat ctgcgttctc atgcaattgt ggatggtgcg ttccggtctt 1871701 gagacacggg atgaattaaa agtgatcaca ttattccacc ttattgggct tgctctggaa 1871761 ctttttaaag tccatatggg ctcctggtct tatccagaag aaggatactc caaaatattt 1871821 ggagtacctt tgtatagcgg ctttatgtac gcaagtgtag ccagttattt gtgccaggca 1871881 tggagaaggc ttaaggttga actggttaag tggccgtctt tttttgcagt tgttccgctt 1871941 gccgcagcga tttatttgaa ttttttcacc caccattttt ctatagacat tcgatggtgg 1872001 ttatcagggc ttgtcatcat tgtcttttgg caaacatggg ttacatacga ggtgaatgga 1872061 gctcgttacc gtatgccgct cgcactttct tttatactca tcggattttt tatatggata 1872121 gcggaaaata tcgctacgtt ttttggagct tggaaatatc caaaccaaat cgatacatgg 1872181 agtctcgtac accttggaaa ggtaagttca tggctcttgc tagtgattgt tagctttctt 1872241 atagtagcat cattaaaaca agttaaggag cagagtccca caaaggcaga gatggatgaa 1872301 tctttttctt agcatacgca tacaagctcc caaatagagt gaaaagcaac gttcaaatgg 1872361 ttgctttttt cttttatgta actctgccgg tgagtattca tcttcttcaa atttcatcgc 1872421 aacacgataa ctgattcaga ttacaactgc tttcaacact ttgacaaact catgcgccgc 1872481 cggcgttatc tcttcaaatg aatgtgcgat gacgccaata tcgcgtgtga ccctaggaaa 1872541 gatgtccttt ttaatcaatt gatgcgggac ggatgaaagt gtaaagtttg aaatgatgcc 1872601 gatacccaag ttatttttga ccatattaat caaggtttcg gcattttgca cagttaagtt 1872661 ttcctttaat tcgatgttgt attgcgaaaa tgcgtttgac atcgcgattt catgaccgcc 1872721 tttacaaaaa atgaggtcat cttgatatgt ttcaaggtcg acatgctttt caagttttaa 1872781 ttcgtcacgc tgcggcggga tgacggccac catatagtcg ttacacaata gctgattttc 1872841 aaacggttca aatggagatg ctgcgatccc gatatcaacc gtccgatctt caacccatcc 1872901 ttttatttgg tcagaggttc cttcgatcaa ttctatgcgg atcagcgggt agtttgatct 1872961 gaatgccgca atcgcctgtg gcatgatatt tgttgaaact gcaggaaatg aaccaatttt 1873021 caccttcccg tttaacagct tgttttcccg gttggctact tgatatattt tgctttcaat 1873081 tcccttcatt tgcctcgcca gcagcaatat ttcttttccg atgtcagtca gcattaaacc 1873141 atgatgttta tccctgatca ataatttgag ctgcagtgag ctctccaggt tttttatcgc 1873201 tttacttacc gccggctgag agatgaacaa ttcttttgcc gcttctgtaa tatttaattt 1873261 ctccccaact tttacaaata tgtgaagatg gttcatgttc ataaccattt ggttataccc 1873321 ccaataataa aaatgtattt cagttataca taaatgtaac atatgataga aaccagcacg 1873381 atattttaac aagaaaggcg gcttcattat ggtaaaagtt atgctgggaa tcatatctgt 1873441 cacacttatt tggggttata cttgggttgc gatgaaagta ggaattcatg acatcccccc 1873501 gcttttattt tcgggtttgc gcctgttcat cggagcagtt cctttatttc tcattctctt 1873561 catccaaaga aaaaagcttt caattcaaaa agaacatctc aaaagctata tcatcatgag 1873621 cctgttgatg gggctgggct atatggggat tttgacgtat ggaatgcagt ttgtcgattc 1873681 agggaaaacc tctgttttgg tatatacaat gcctatattt gttacggtga tcagccattt 1873741 ttcattaaac gagaaaatga atgtgtataa aacgatggga ctggtctgcg gcctcttcgg 1873801 actgttattt atatttggaa aggaaatgct caatatcgat caaagcgctt tatttgggga 1873861 gctgtgcgta cttgtggcag cgcttagctg gggaatcgcg aatgtgttca gcaagctaca 1873921 attcaagcat atcgatatta ttcacatgaa tgcctggcac cttatgatgg gagccgtcat 1873981 gttattggtg ttttccttta tatttgaggc ggtcccttca gccgagtgga catatcaggc 1874041 ggtgtggtca ttgctgttta atggcttgct ttccaccggc tttacctttg tcgtatggtt 1874101 ttgggtgctc aatcaaatcc aagcgtcaaa agcatccatg gcattaatgt ttgttcccgt 1874161 attggcccta ttctttggat ggctgcaatt gcacgaacag atcaccatca atattatcct 1874221 cggcgcactg ctgatatgct gcgggatttt tatgaataca tttacatttt cacgacggaa 1874281 agtgtgaatg atatacattt cccctgtcat ttgggcttca tgtgacagga gaagactatt 1874341 acgagaaagt cttctagaat cctgacgaca gcctattaaa caatgaaaaa agctaatgtc 1874401 tgcatgtaga cattagcttg gctggcgttt aggctggtga gaatccagat acttttttat 1874461 taccattctg gctgatcaaa ctgaaaaccg tatagacctt ttactttaac atctccgcaa 1874521 tctggatctt ttgtcaaaat caaataatga gtcttataag gcatcgtctc aactcgatca 1874581 gttgcactaa aatcaaaatg atcccccgag aagttttttt cactaacggt tatttcatat 1874641 cctgacaaag tcattcgcat gattcttgcg ttaattgtac atccttcagt atcgaaaatg 1874701 gtgaatctgt acccaaagtg agatgtccaa tggtttgaat ttaggtcatc agacttcata 1874761 aaccattttt cattctctgt cattgtaaaa ctcactttct cctcatcttt cacgataacg 1874821 gccgaagctt cccctacatg gatagtcaaa gccaaaagaa atgtaaaagc taacatcaac 1874881 atctttttca aaagagttcc tcccgatatc ttttacttca atatattgga agggtctttt 1874941 ctgatcaaga cagtcttctc caaatgaatc tttagcacca tgaaatgagc cttaataaga 1875001 acagttttaa cccaaatcaa cctctattcg aaataaggct taccaatcta tattcttttt 1875061 aaaagtttct gcatttcttt atttagctcc tagacacata taaaaaatgc tcctataagt 1875121 tcaggagcac tacaaaaaac tgctaaagtg ttttctatcg atttattgta ttcattagct 1875181 caaagaaata ttcaggcttt tgagtcttat ttagcttata ccatgaacgc aatgtatctg 1875241 gtgcaaatac atctaatttt ttcaatactt ctaccgcaaa ttccagagga gcaattcctg 1875301 atgcagtaac caaattttca tcagatactg caggcccctt ttcatagaat gtttctcctt 1875361 tgtaattagg gcagaccata ttcatatagt cgaggtcatt gcttgtgtgc tttctcgaat 1875421 ttaagtatcc ttcattcgcg aggcccaagg ttgccccaca aattgcagca atagtcgtgc 1875481 cgagctttaa agcgtcgcca acttttttca agatcggctg atgaatatct tctccccaag 1875541 tgtttcctcc gggtaaaatg ataagatctt gactcccaag agtacattcg tcaagagaaa 1875601 tatctggttt tatgcttaat cctcccaacg tagttatcat ttctttatta acccctactg 1875661 taactacttt taaagatgct gcatcttgtt taaagtatct ccctgagttt agttccgcaa 1875721 ttaaatatcc atattcccag tctgacattg tgtgaaatac gtagagataa acttttctcg 1875781 tttgcatcca ataacactcc aatcacaatt gataaagctt tctaatagat gactttgctg 1875841 acagtcattg tcagcttttt tgttgattct attcttatgc ccttgttctc ccaacttata 1875901 aaaatataag atcaattgat tctatgttta ctagcgcaaa ggggtttgtt acactaactg 1875961 tcatgggaaa catttcaaag gtaatacaaa atcatttgaa tgaggaggcc tgatgaagtt 1876021 gaaaactaaa gcgtcaataa aattcggaat atgtgttggg cttttatgtt taagcattac 1876081 tggtttcaca ccttttttca actcaacaca tgccgaagca aaatccatag aagacacaaa 1876141 catggcaagc tgtataacga ataaaaaatt tgttcaactt gagaaaaaat ttgatgccag 1876201 gcttggtgtt tatgcaattg atataggttc aaacaagaca atcgcctatc ggccgaatga 1876261 acgatttgct tacgcatcaa cctataaagt tctagccgca gctgctgtcc tgaagaaaaa 1876321 ctcaattgaa aaacttaatg aagtcatcca ctacagcaag gacgatcttg ttacatattc 1876381 tccaatcaca gagaaacacc tagatacagg catgagccta aaagaaatct cggaagcggc 1876441 tatccgttac agcgataata ccgctgggaa catcttgttg caacagcttg gcggccctaa 1876501 aggttttgaa aagtcactga aacagattgg ggatcatgta acgaaagcta aacgattcga 1876561 gacggatcta aactctgcga ttcctggtga tattcgtgac accagcaccg caaaagcact 1876621 ggcaaccgat cttaaagcct tcactttaga taacactctc acgactgaca aacgcatgat 1876681 cttaaccgat tggatgcgag gcaatgctac tggtgacgaa ctgattcggg caggcgctcc 1876741 aataggatgg gaagtcggcg ataaatccgg agccggaagt tacgggacac gaaacgacat 1876801 tgctatcgtt tggccgccaa acagagctcc tattgttgtg gcaattctgt caaaccgctt 1876861 tacgaaagat gctaattatg ataatgctct tatcgctgag gctgcaaaag tcgtccttaa 1876921 cgatctcaaa taatatgttt agccttttgc cacaaaggaa aagacattac ttttttaact 1876981 tctaccgttc attttttgat gaacggttct ttcataagac ctctagaatc atatatttaa 1877041 acaccacaaa attaaacatt attataatta acagcaagtt ttcattttat ggaacaagta 1877101 aagtttgaat ctgacaagaa ttaagactaa gcaccctaaa atccgttttc ttttcttcca 1877161 agaatatact ccttagtgca agccattata aagatacaag tgaacataca atgcagacaa 1877221 ctctcttaag tctcttattc tgtgaccaat ttgtaatact catgaatatc cggactcact 1877281 tccaatattt cgtctcgttc gaagacacta acatatcaaa ccacttgaat taacataact 1877341 gaacttgata ttggtcactg gcagtttcaa tgcaatagaa caacatttgt tgtctcagag 1877401 gttatctata tgagaattca acaatttttt tataataatt catatttttg tatcgttgca 1877461 cttggtggat ttgactcttt tcgtgtatgg aaccacactt ttattttttc acctcttttg 1877521 agatcatctg tgttatcaat ctcacttaat cctacaatta ctatgttatt tttaaacttg 1877581 ttcataagtt gtccttcaga aagattgtaa tcttcttttc ctggagcttt tgtatcggta 1877641 atgagaattg ccctttcatt gtctttaagc acgacatagc ctactaggct ctgcatcttt 1877701 gtttcgtctc cgttttgttc atttttattg cagcctgcaa ggaaaataat gagcataatg 1877761 agcactatca agcttactcc gattttaggc atctttcttc ctcctcttta aactcatctt 1877821 taaaataaac aacaggatat cacccaaccc atctacttct ttttgcaatt cataacagca 1877881 gcatactcat tctccaattc ctcaaccttc tttttattct ttctcaaata tttgcatgtg 1877941 gtagccctcg atattatccg cttactcatt tttgcgcttt caaatatatt attgaaggcc 1878001 gcttctttct ggattccagc ataaatatac ttatccttac tgtcgtttac tatcgcaact 1878061 tccattaaaa tcgagatttt tacttttttt atgatccatt attcacttcc aaaataactt 1878121 ccaattacaa cataatatat gtataaattg taaatggagt tgatgtaatt gaagattagg 1878181 aaaatcttat tgagttctgc tttatccttt ggcatgctaa tatccgcggt tcccgcattg 1878241 gctgctggca cttcgtctga ggttgcagta aaaaatgaag aatatgatta tgacactata 1878301 taccgcatta gtcctctgcc aatggacttc cagccaacaa tagaatacaa cggttatact 1878361 tatacgctta cacgtcatta ttttgattac tcaatcgggt tttacacggc tatttataca 1878421 aaagttgttt aaacttataa aggagctttt tagctccttt ttctcttgtt ttaagcaagg 1878481 tatttctttc tatgtggtcc cctatcaaat acaacatcaa cattctccag ttctctttga 1878541 cacgaacaaa atctaaagtt tggttttaaa tgctggtaat aaaaaattca ctttaaagaa 1878601 gtgccgcccg caaaatacgg cttttgtaca ctacgccaat tttatattga aaagccagac 1878661 ctcctcaaag aggttccagc ttttcttaat gtgctatcga tcttcgttag ttcaacggga 1878721 actttatcat tcggtacaaa tgcagcctcc caacttctag ttagggctga tggcggaata 1878781 tctgacggtt ctctacacac atcagacatt agaagatttc aatgtagcct tctgtaccat 1878841 gaacgcgaat tcgttgccca tcttttatca gcttggcagc attttcaacg ccaacaactg 1878901 caggtaagcc atattcacgg gctataacag ctccatgggt catcagcccc ccaacttcgg 1878961 tgactaggcc ttttatggat acaaacaatg gtgtccagct tggatcggta aaggaggtaa 1879021 ctaatatatc tccatcttct aaatccgcat cttccatgtt taaaatgaca cgcgctcgcc 1879081 cctctataac tccggaggaa acaggtagac ctacaatcgc tccggctggg agattttctc 1879141 gtttatactc acctgtaacg atttcaccat cagacgtgat aacacgtggt ggagatagtt 1879201 tttcatataa tgtgtactcg tcttttcgtg tactgatgat ttgataatcc agtttatgtg 1879261 tgcgcacgac ttcgtgaagt tcttcaaaag tgagatagta tatatcttct ttttcatgaa 1879321 taacgcccgc ttctatgagt tgttcggctt ctttcagtaa agcctgctta taaacgaagt 1879381 atcgattaac catgccgtat tttggatatt ccctaaaccc gctgaaattc cggatgatat 1879441 ctatcgctcg ttttgtttct ttggcttttt gttcaccatc cggtaattgc ttcaatcgat 1879501 ctaataactc ttgttctttc ttcaaagctt cctgtcgccc ttgctcaaat ttccgatggc 1879561 cgacattagg ctcaaaattt ttaatattat taagaatcat tgggacaagt gtagttggtt 1879621 tttcgctcca tcgagttctt gtgatatcaa tctctccggt acatcgcatt ccgtatttgc 1879681 tgagataatc atagatcgcg tctcgggttt tgcttccgcc atcaaactta gccagttcat 1879741 ccaaaaagtt atcatctttt acatgttgta agtaatcaat tacctctgga taaggacgaa 1879801 tcacatctgc gacgtctaat agcgcaagac ccatttctga agtaatatta tggggtacag 1879861 attgagaaag cgtatctgct gcgttttttt cacctaacca ctcgttcatt ttttcgttaa 1879921 tccataatga agcattcata gcagttcgaa ttagaaccga actttttggg ttaaataaaa 1879981 tcttctttaa ttcctgaata tcttccagaa taaaacgaaa taaatctgat cctgatttcg 1880041 tttggatgtt ttgttttaac tcttctatcg atgtttgact gctctcaatc aaatcagaca 1880101 cgattgtcgg atcgttttca acttgagccg gcatatctgc attgcctctg ctgggatttg 1880161 gtgctgtttt atcatttggt atcgacttta tgaaatctcg tcgctttatt atggtcataa 1880221 gtgcgtcttt taagagctga tcgtgctgcc ccatgccttt taagaaaact tctctgctgt 1880281 caggggatgc cagatgatgt gtgacatcaa caaatagcct tccaccggct ttacgcatgg 1880341 gtgcaacagt cgtcaacaga aaaaaagaca atcccagtgg ttttatggga tccgtcatca 1880401 tttgttgatg accaacagaa atatagacgt gattttcttg gtcactcgct tcagggatgg 1880461 ggaataaagt agtgattgga cgactctgta caatataaaa agtatcgcgg gccaaacacc 1880521 attcgatatc ttgcggctgg ccgaaatgag cttcgatctg tcttccaatg cgtgccagct 1880581 gtaaaatttg ttcatcagtc agtgtttgag ccttttgctg atcagaatcg atctgctgtg 1880641 tttctgttcc gccttctttt cgtccgtaga tagccatttt tttagttgct attctcttat 1880701 cgatgatttg cccatcctgt actttaaaac aatcggcaga taccaagcca gaaaccagtg 1880761 cttcaccaag tccaaaaccg gcatcgatgg ataacacctt tcggttggag gtaatcggat 1880821 cagcggtaaa taaaatcccc gaagcctgag ggaaaaccat cctttgaacg ataacggata 1880881 aatagacttg gctgtggtca aatccatttt gcatacggta aataaccgcg cgatccgtaa 1880941 atagggacgc ccagcattta ctgatatgct gcaagattgc atcgacgccg gtaatattta 1881001 aataggtgtc ttgttgaccg gcaaaagaag catgtggtaa atcctcagca gtcgcactag 1881061 aacgcacggc ataggcatgt tcctcgccaa actgggagag atattgagcc actgctttca 1881121 caacatcgga aggaatgtct acttccataa tgatttgccg aatcttccgg ctgatgttac 1881181 caatctgatc tcggtcctca acttttagca tggtcaattg atccaacaac acttgtaacg 1881241 tttcgttttg ttcgatggct ttttgatatc ctactgttgt gacacaaaat ccttctggta 1881301 cttgtatacc ttgaattttt gataattccc ctaaatgtaa cccttttcct ccaacgagcg 1881361 aaagctgtgt tttttcaatt tcatgtaaac cgagaaccaa agaactcatt ctacatctcc 1881421 ccttcaaaaa aaaatattga caagagcttc ctagcaggat ataataaaat tataagatgg 1881481 atatctataa ctttttaact agaaagcgca cgtagtgtga ttatatcacc gtgtctgttt 1881541 ttgtgcaata taaaaagaac ctgggaaatt tcaccaggtt cttttcttaa tttccatagc 1881601 tagtcgcatt aaaaaacttg gtttgagctg attcaatcct ctaaggaaat cctaaagttg 1881661 ggttcttttt gaacttactt gctttgttcg tagagtcccc attcataaat tggacttttt 1881721 gttcttaaca gtcccacctt taactagtat aaagttatga ggatctggtt aactactaga 1881781 tatttttatt ttgaataagg cttatgtttg ataaagaagg gttatgtaaa ggtgtctgtt 1881841 gtgagcaagc gctgactaca aaaaattgat agcattctca tttaaatacc attctattaa 1881901 cctataggga aagttttaaa accagatgga gaatacccta cctccagcaa ttccaaggcc 1881961 gttcacctag tagaaaacaa cctttaacca ttactaacga ttttaataat cattgattat 1882021 aaaacttctc aaggaacgat cagcagcccg ttagctaccc ctgattaagg atgatctgtt 1882081 accacactgt tacgttagaa cttccactac tttgatatcc ttctgtcgcc atgacttggt 1882141 aagcccaatt actgcccaga ttcattccat ggctcttcca tgcgttcaca tgattgctga 1882201 aagtgattgt agcgttgctt ccggttggtc tcttcgactg gcgaacactc cagtactgcg 1882261 taaaagtagt gcgatcgcca tcaatggaag gtgcgttata acgtgtagtt gtatatatgt 1882321 catatgtacc cccatcactt tttacagtac ctttatacgt tccagtaggt ctataagtac 1882381 cccatgaatc cactacataa tattctatga gaggtgatct cgtccaacca tataaagtta 1882441 aatatccatt gccattcggc gcccaaactc cggcattata gtttatcgtc ctaaatggcg 1882501 aacctgtagt ccaaccttta ccaacaacaa aatttccggt attagaccaa ttaacactgt 1882561 aattcccgcc agacccattg acagcgttta ctataccgcc cccatcagtc caattttgcc 1882621 agtagtctgt gctagctgca gaggcggttg ccgaaaacaa gctaatactc attaaagctg 1882681 ccgataatcc aactaagaaa ttctttttaa acttaaacat atgttacctc ctataatatt 1882741 ttttccgact ttgaggtagc actcgtatac atttaaaaca ttcttaatta ctaacgccaa 1882801 agcttttgat cgtccccttc agtataatac cacgaattca tgagcaaata ttaaaagtat 1882861 ttgtaattca attacaaata cctagaaaca cattataagt ggtcttcttc caccatatcc 1882921 tgatccgagc tcgatgtaca tgcctttacg gcacacacga atgtggcgtg tggtgcatcg 1882981 cctcaatacg caaagacgtt tgccttaggc aaacgtcttt ttttgcgtta tccgattttt 1883041 gtgccgtttg ggacaggctg atccggctgc aaaaggacga cgtcgccctg gccgggtatg 1883101 ccgccgagga ccaagacttc cgatttaaat ccggcgatcc ggcggggcgg aaagttcacg 1883161 actgctatga cttgcttgtt gatgagacct tccggcttgt aacgcttcgt gatttgtgcg 1883221 ctcgattgtt ttatgccgat ttcagtccca aaatctatca caagcttgat tgccggtact 1883281 cttgcttcag gaaattcttc cgcttttaca attgttcccg ttctgatatc caatttctca 1883341 aagtcatcaa taactgccat atcaataact cctttttctc ctattgtaaa ggagatatac 1883401 aatattcttt taactaaaga gccatcattt tttatccgaa tataaggtgt ttcgatacag 1883461 gcggggcggc attcctgtgc ttttcgtgaa ccatcttgta aaagaagaaa ggttttgaaa 1883521 gcccagcgcc tcgctcacga cggtaagagt ttcatttctc tccatcagca ttctttttgc 1883581 ttcctcaagg cgaaggtcgg caatatagtt ctgcggggac ttccctgtct gttttttgaa 1883641 ccagcttgaa tagtaagctg ggtgataatg ctcgatttct gccagcttct taatcgtcag 1883701 ccgctcaaat aaatggctgt gaatgtatgc aattgaggca tagctatggg attgaagctt 1883761 ttcttttatg tattgtacta gcatatgaag cgagttggct gttccggcct ttgcttcctc 1883821 tgtcagcaag tacctgatcg aagaccagaa aggatcgagg gcagcttcaa ttcctgatcc 1883881 tgcacgatac tcatcaattt tcattgcatg aagcggaaca tccagtacaa gacattcatt 1883941 tcttccgata gaacggaagc gatgctcgca ctgcggcgga atatataaaa aatgatccgg 1884001 atttaatttc acctggcgcc cctcagtctc aagatcaata ctcccttcaa gcggaaaaag 1884061 aaattggctg tacgcgtgct tatgtgaatg atatagccgt gtgtatgtcc gtttttcgca 1884121 aattatctct tgaagcgagt ccattagcaa accccttcct ttggtcatct tttaatccgg 1884181 taatggtgtt ccgatatagg cgaaaagccg atttttccat ataaagaaac tgccgccaga 1884241 ttttctttca tcacttgtaa aaacatgcgt tccgctccgt tgttttttgc ccattcagtc 1884301 aacaccctga tcacttgggt tcctgcccct tttcctctgt gctcctcagc tacaacgata 1884361 ttactaagtc cgccataacc atcaatgaca gaaaccgtgc caagcgctgt caggctttct 1884421 ttgtcataca tcttgaaaaa agttttacac ggcggcatgc gttcgaatat gtgtttgtaa 1884481 cctttgtgac gctcgggtga aaacccttct aattgaataa attcatctat ccaaacagat 1884541 gatggctctt gttcccactt gtatgtaaat cggctgttgt catttgttcg gctcataatt 1884601 gaccggcaca acgctgtcat ctggaagcac tcgtctacct tttcataacg gctgtctgcc 1884661 aatgcgtcat caagcccttt cggtgatgcg ttgctaatat gaaaacaaac aggtaagcct 1884721 aaactttgat aaaaaagttc ggcctctagc tgaaaatccc cttcaggcat atccgcagac 1884781 gtccatacgc tatttgccct tttggttacg ccaaaattcg ctctgagaag ccatttccct 1884841 atgctttttt gaaaataagc cggccatgaa gctgccgcta atcgttcaat cttgcgaatg 1884901 tcatccattg cataatgcct ctcccctatg tatactccct tgatattata caatattcag 1884961 aaatataaga catccattta tttgtttaca taatattttt attgtttatt aataatcctg 1885021 acaaaaatgt ccgaattgaa aatgacaggc tttctaaaat gtcctcctca cgttcaaatg 1885081 cttcttttgc gattaaaaca gtaaagccat gcagcagact tctgagcccc cttgtcgcat 1885141 gaatggcagt cttttcactt gcatagccgt tttcaatgag cagcttcgtc acaagacaga 1885201 caatttggtc agagacgatt tccgtccgtt tgtcgtgaac cttaagaaga gccgcttcat 1885261 aatatccggg attttcaatt gcaaaatcaa catatgcatg agctaaagaa agcatcgcgg 1885321 aatctccctt tcgttcggtt acggagtccg ccatttgatc aaaaagcttt gtcagtcctc 1885381 tgacagcaag ttctgctctg atcgcttgca gcccgttgat atggttatac aatgacgggg 1885441 ggcgaacatt cattttttta gaaagtgcag caagtgagac accatttacc ccttcctgat 1885501 cggcaatctc tgctgcagcg tctacaatca ttttttgggt caaacctatt ctcggtgaca 1885561 tgctcatcat cctttctttg ctttttggat cgcctgtctc atccgctctg aaggtgatcg 1885621 caggaatttt ccatgtccga cagcgagaca ggaaggcgcc ttatcggcga gcaattgtgc 1885681 acttttgatg gcctcctcct tattccatgt ggcgaaagcg ggaaaaggaa acgcccattt 1885741 tatctgacct gatacagcga ttcctccgcg caactgaaac gcatctcctg ctattaaagt 1885801 gccgtttctt gtatcaagaa atgacatgct gcccggtgta tggcccggtg ttggaatggc 1885861 aagcagagaa ccaattgttt caccgcccgt cagcagttgg tgaggctttg tttgtatgtg 1885921 tttcggaata cctcctttta taggcgtctg cggctcatct tgccgcaaag atgtgtcacc 1885981 ttggagcaag aatgaatccc gttccgagat catgaccttt gcatgcggaa atgtttgtgc 1886041 caatgtatcc agtgatccga catggtcccc atgtgcatga gtcagtaaaa tatgctgaag 1886101 cggttttcca agctgattca cagcttgaat aatcccttta tagctgcctg gcagtgcggc 1886161 atcaataagg gtgacttcgt tttcttcctc tactaaatag caattaaccg gaaacaatgc 1886221 tggaaaaaaa gtcagctgcc aaaccgtttg gtactgagta attctcatct ttttattcct 1886281 cctaacaaaa actaatggtg ttagttttat tattaactaa caccattagt ttttcaagag 1886341 tttattattt ttttatcgct acataaatgt taacttgtgc tcgctgtggc actgcggcat 1886401 tttgatcata catctcaaag tcacctgtaa acgtgcgcag atgccgctta tcccaagtcc 1886461 aaatttcctt ccacgtttca agcacaatct cttcaatagg accgattctg gaagtgaaaa 1886521 cggcgtaagc ggaagccggc aaatcaatat tttcatatgg tcccggaaga atgtcgtcgt 1886581 attcctgaaa cgttccgact gaaaacgtat aaaacccatt cgtctcttgt tcataattcg 1886641 aatataaggc aataatgctc ttgtcttttt cagcctgtga taaaagagcg ctcatatcct 1886701 gcttccataa ttgatcccac agtgccggaa tcctcctttc ttccgtcatt tccagtgcgt 1886761 tgcttgtccg ttgtgatagt ccggcaaatc gtttcaggtc taagtgtgtt atatgtgaaa 1886821 agcccatacg atctcctcct ttttttaaga ttatagacaa agaaacctga cagcagtgtg 1886881 tcaggtttca tatatttttt gcatgtgatg aatggtttct tttactttat cccttatatg 1886941 aagaggctgc agaacctcaa tatcctttcc gaactggagc aaaaaaccga tcagccattg 1887001 atcttctgga agtgaaatca ccgcctggca gatttcatct tcctcacaac agtgaaggac 1887061 atcatatccg aaccattcac ctatacgctg acgtgctgac ggctgaacaa gaataaccaa 1887121 ttcagttaaa cggtcctttt ggtaccaact cttatcccat ggcaaagtgt ccagctgaat 1887181 gtcttttctg ataaatgtct gatgtaagat ggccagatct ttcatccggt tcagtttaaa 1887241 aaagcgaaaa tcatttctta ccaggcagta ggcatataaa taccagtgcc ccgccttgca 1887301 aaccaatgta taaggttcag tttcccgaag tagtgtttcc ccgcttgcgc ttgtatatgt 1887361 aaaagatatc gttaacaacc gatcgatggc agcgctgatt ttctcgcgca gcgtcttttg 1887421 atcctcagta tggccccaag ccgtcatgtc aataaaccat ttttctgttt ggtgcttaaa 1887481 tgcttgagta gattgctcag gtataaggtg tttgattttt tgataggctg tgctgtgaga 1887541 aacgggttca tacatagatg aaacgctttg caaagcggaa gcaattgcaa acaattcctc 1887601 ctccttcagc cactctcttt caagccgata cgtttccatg atgccaattc cgcccccgga 1887661 accctgtgag gtcacaatcg gaataccagc cctattgatc gtctcaatat cacggtaaat 1887721 tgttctgaca gatacttcaa acagctcagc aagctctgca gcctgcactt gttttttgct 1887781 gatcaataac acaaccatcg ctaacaaacg ttccagtttc attctgcgca ccttttcttc 1887841 ttgtattttc caacaaaaca atcataacat tttgataaag cttgggcata tctattatgc 1887901 ggcggaatac acctcgcata tgctatgaaa acaggggttt ccccttcttt tttgtgttca 1887961 gtatttattt cagctactat ttccgaccgg ataagcatac acttctcaac ggaggggatt 1888021 tcacatcatg catcttacac ttcagagcgt ttatcctgcc ataatcatca tcttttttct 1888081 gtataaaaaa attaaaaggt ccatcggata ccagccgctg aagccccgct ggctgttcac 1888141 ccgtatcatt cttttctcgc tgtttgcttt tggactttca atcttcagcg ccattcaccc 1888201 ttttttatat ggatatctca ttttgggcat tcttggcgga tggctccttg tctttttcgc 1888261 taagaaaaac atctcttttg aaaaacgcag aggaaagatc tattttcgga ctcatatttg 1888321 ggtagaggtg attctcttaa ctttatttct atcaagattt ctgtatcgag tgacggagct 1888381 ttatcttacc tcacctgatc taaaccgcct tggatcatac agtcagtcaa tcggaacgga 1888441 ccctctgaca attggcgtct gttttctgat agccgtttat tatatcggtt tttcttcttt 1888501 tatcatcaag ctcagcagaa acgaacttga acagcacgaa tacaataaag aaaaagacat 1888561 ccttgcccgc taacagcgag ttaagcaagg atgtcttttt caatcatgct gtgtatgatg 1888621 gatcatttgc tgaagaacat ctaaaacatg ttcatcctcc ggagagtaat aaatcgatgt 1888681 tccttctctg cgcgatttga caagccggag attttttaaa aatctaagct ggtgggacac 1888741 agtggattgc agtaaattca gcttttctgc aattccgttt actgcatgct caccttggga 1888801 caataaatgg agaattctga ttcgggtagg atctgaaagc gctttgaatg tttgcgcgac 1888861 tagaaacagc gtctcctcgt ccagatcagc agccgattgt tccgtttctc taaattcagt 1888921 catatgtatc acctttcttt attcatagtt ttatcttata acaaatgcgc ttgagtgcaa 1888981 accagcctgc ttgtattcca tttcaatctc atagtttaaa tttatgtttc aaatcaggtt 1889041 tttacttggt ctgatatacc ctcttatgtc ataataaaaa aggtcatact gctccaaaca 1889101 ttgagggtga aacacagtga agaaaaagag aaaaggctgt ttcgctgctg cgggttttat 1889161 gatgattttt gtctttgtca tcgcctcttt tttattggtc ctgctttttt tcaaccggga 1889221 tttaatcaaa aaacttccga tcgatacgaa aacgattgtt ttggaacgtt taaccgatta 1889281 caaacccttg gtggaagaag agcttgaaag ccaaggactc tctaattata catcactcat 1889341 attaggcatg atgtatcagg agtcaaaagg aaaaggcaat gatcccatgc agtcctctga 1889401 atctctgggg ttaaaacgca atgagataac agaccctcaa ctcagtgtta aacaaggcat 1889461 caagcaattt accctcatgt acaagaccgg taaggaaaaa ggcgtggatt tggataccat 1889521 tattcaaagc tacaacatgg gggcaggtta cattgatttt gtagctgaac atggaggaac 1889581 gcatactgag gaattggcaa aacaatactc cgagcagcaa gtcaaaaaaa atcctgatct 1889641 gtatacttgc gggggaaatg cgaaaaattt ccgctatccg tattgctacg gtgattatac 1889701 gtatgcagaa aaagtaaaag aaaaaacaaa aactgttgaa gaatctttgc aggttgcaac 1889761 acttgaaacc atggaatcca aggctcatga ataagagtct atcaatttac tgacaaaagc 1889821 ccaaaaatga atttgggctt ttgccatgtt tacacgtaaa aaaagccata ctgagtatgg 1889881 cttttaataa tacggtgaaa tcatcaaata tacaataacg cctgtaaggc ttacatacag 1889941 ccatagaggc attgtccatc tcgcaatttt tttatggcgc tccacctgca tgctgaagcc 1890001 tctgatcagc gtaaacagcg caagcggcac aataattgca gaaaggcaga tatgtgtaat 1890061 taaaataaag aaataaatcg ggcgcataat accttctccg ccatagagcg tgttttccgc 1890121 aatcgagtgg tacgtcacat agcaaatcaa aaatagtaat gttgttgtga acgcagccaa 1890181 aataaagcgt ttgtgagctt tgatattttt ctgtttaatc ataatcagcg cggccaataa 1890241 gaagataaac gtaaagctat tgaatatcgc attcagcatt ggcaaaatgt gaatattcgc 1890301 atggctgaac tgatctaatt taggcataaa aaacagcact gcgattaaac cgttaatcag 1890361 aactgtcagc gtaaggacaa tccccgtgta atttttcggt ttattttctg tttggttcat 1890421 ttggtgacct ctcctaattt gtactggcta tccaaatcgt atgcaaattc aaagaagatg 1890481 tcaacggttt cgattgcttc gtcagaaatt agacacactt caaaggccgg aggctattag 1890541 ccccggcctg ttaggtttac gcctctttta tcaaatgttc aatgacctta tgttcatttt 1890601 cattcagcag gttcttttga attttcgaat gaatgggttt attcatatgc tgatccaaga 1890661 tatcggccgt ttctttatcc ccggcaataa ccattcgttc ccatcttttc gcggcagctt 1890721 tttgatcaag gctggcagcc agccgcttat acagtctcga ttggttctct gttacatgtt 1890781 ccctcatccg gttctcttca aatggtggcg ctttgtctac agcggaatgg ctattcttcc 1890841 aagactcatt gatcatatca tactcataac gctccaccgc ctcaattttt cctaaaacag 1890901 tttcaataat tttcacttca tgctgctgag ttaaaataaa cgccgtactt gggtatgtct 1890961 ggcgcaaacc ctttagctga tccaggacag ctgtttcttc ccagtaaaat cttgtatcta 1891021 cagggacttg aagcttaata ggttcccata tgccgctgtc ggaaacaaaa aacacgagac 1891081 tgcggggcat gtcttttccc attgcattca agtattgatt cattttagcc ctgattccat 1891141 ccagacactt ttcctcctct ggatcactag ctgccaaata ctcttttaat cggctgaatc 1891201 ctgactttag ggcaatcttc cattctcccc cctgctgctc tggatctctc atgtctgtat 1891261 tgagatacag agagagaatt ttatccggcg gttccaattg gacatactgt aatttgttaa 1891321 tcaatgaatc aatcgccatt ccgattcctc ctttttcaca ggttagtttt ctttttcctc 1891381 tcttaaaaac gatcaaacct gactttccgc taatttctag taataatgga attgttgttt 1891441 acaatacgcc tctcttctaa tacaattggt aactgtgttt ctaagctgtt ttttgaaagg 1891501 agtttgatct tgtttactgt taaagaaaaa aatcgtcaag agcttgagga agaactaaat 1891561 gatttagaat ttcaaattta tcgcatgcag gagaatatga aggatttatc taaagatgcc 1891621 aaagtgcttg gtattgatca atcgaaacat gatgagtgga tgattgtttc ctcgattgat 1891681 gatggccaaa catgcaaaat tatgctaact gattgtaaaa cggcataccg aggaaaaggc 1891741 tgtttttcac ttgtagcgtc ttacaaggac gatgccattc atatagggga tataaaaggc 1891801 cctccgaatc acgggtttgg ctccatttgc atgaaatatt taaaagatat tgcaagagac 1891861 cataatatac cgaaagtcac cggagacatc gccaaacggg attggaatca tgtagaccgg 1891921 ctgattcact tttatgaaaa acatcacttc aaagtatgta tcgatcatga tacccaatcc 1891981 ggcagcatta agtgggttga tttgtaaaaa agtctggaag aaagagccaa gatatgctgt 1892041 aatggtataa aaccattgat ggagggttct atgtacgcct caaaactgaa aaagggagac 1892101 gaaatccgga tcgtgtctcc cgcgaccagc atgtctatat tatcaaatga agcaaaaatc 1892161 caagcaaaaa cggcgttaga acgcttaggt tatcgggtaa ccatcgctga acacgcaaat 1892221 gaatgtaacg aatttgattc atcctctatc gagtcaagag tccatgatct gcacgctgcc 1892281 ttttttgatc caggcgtcaa agcgatttta acgacactcg gagggtttaa ttcaaatcag 1892341 ctgctgcgtt atcttgatta cgagaaaatc aaacgacatc caaaaattct gtgcggttat 1892401 tccgatataa ccgctctttg caacgctatt tatcaaaaaa cgggtcttgt tacgtattca 1892461 ggtccccact tctcaacatt tgcaatgaaa aaaggactcg attatacaga ggagtatttt 1892521 ctttcttgct gcgcttcaga cgatccgttt gaaattcacc cctcaagtga gtggagcgat 1892581 gatcgctggt ttttggatca agaaaacagg cgtttttatc ctaataacgg ccctgttgta 1892641 atccaagaag gttatgcgga aggtacttta attggcggaa acttatgcac gcttaatttg 1892701 ctgcagggaa cggagtattt tcccgaaaca gaacatacta ttttattgat tgaagatgat 1892761 tatatgtcag acatccatat gtttgaccgc gatctgcaat cactcatcca cctccccgct 1892821 ttttcacatg taaaggcgat tttgatcggc agatttcaga aagcatcaaa cgtatcaata 1892881 gatcttgtaa aagccatgat cgaaacaaaa aaagaattat ccggcatccc gatcatcgca 1892941 aatataaatg ccggacatac ctcgccaatt gccacgttcc ctataggagg aacatgcagg 1893001 attgaagcta tttcgggtac atcacgaata tggattgata aacattaatc agcttgtaaa 1893061 tttttttaca agctttttta gcgcaatcgg ctatgcatgc cgcacgagac atgacaaatg 1893121 tcatatagga ggcatgatgt gtgctactac aaaagacttc tctcattagc gtatactgaa 1893181 ccgagacaca caatgagagg atacttacta tgactgaaca aaccattgca cataaacaaa 1893241 aacagctgac aaagcaagtc gctgcatttg ctcagcctga aacaaaaaac agcctgattc 1893301 agcttttaaa cacgtttatc ccattcttcg gcctatggtt tcttgcttat ctcagcctcg 1893361 atgtctccta tcttcttacg ttagcattaa cggtgattgc cgcaggtttt ctgacaagaa 1893421 tttttatcat cttccatgac tgctgccatc aatctttttt caaacaaaaa cgctataacc 1893481 acattctcgg ttttctgaca ggtgtcctga ctttattccc gtatcttcaa tggcagcaca 1893541 gccattcgat tcatcatgca actagcagca atctggataa acgcggaaca ggagacatct 1893601 ggatgttaac agtaaacgaa tataaagctg catccagacg aacaaagctt gcatacagac 1893661 tttatagaaa cccgtttatc atgtttattc tcggaccgat ttatgttttt ctgatcacga 1893721 accgttttaa caaaaaaggc gcaagacgca aggaacgtgt aaacacatac cttacgaatc 1893781 tggcaattgt cgcgttggct gccgcttgct gtctgatctt tggctggcaa tcgtttttac 1893841 tggtgcaagg cccgatattt ctgatttcag gttcaatcgg tgtttggctg ttttatgtgc 1893901 agcatacctt tgaagattct tattttgaag cggatgaaaa ctggagctac gttcaggctg 1893961 ctgttgaagg cagctcattt tataaactcc cgaaactgct tcaatggcta acaggcaata 1894021 ttggttacca ccacgttcat catttgagtc caaaggtgcc taactataag cttgaagttg 1894081 ctcatgaaca tcacgaacca ttaaaaaacg taccgacaat caccttaaaa acaagcctgc 1894141 aatcacttgc gttccgtcta tgggatgaag ataacaaaca gtttgtgtca tttcgggcta 1894201 taaaacatat acctgtaagc cttccgcctg attcaccaga aaaacagaag ctgcggaaga 1894261 atgcctgatg ataaaggagg tcttctaata tactagaagg cttccttttt attgttggag 1894321 ggtgcattct ggctttcaca atgataaagt tacaagtaag atgaaaagct gaaaatgagg 1894381 taagatcatg attaaaaatc attttacatt tcaaaaacta aacgggatta cgccctatat 1894441 atggacgata tttttcatcc tccccttcta ctttatatgg aaatcatcat ctacatttgt 1894501 tattattgtc ggcatcattt tgacgctttt atttttttcg gtatatcgat ttgcttttgt 1894561 ctcaaaaggc tggaccattt atttgtgggg atttttatta attggcattt caaccgcctc 1894621 cattactctg ttcagttata tttattttgc tttctttatt gcttatttta ttggaaacat 1894681 taaggaacgc gtcccttttc atattttata ttatgtccat ttaataagcg cggccgtcgc 1894741 agccaatttc agtctcgtat taaaaaagga attctttctg acacaaattc cttttgtcgt 1894801 tattaccctc atcagcgcaa ttttattgcc cttcagtata aaaagccgca aggagcgcga 1894861 acgacttgaa gaaaagctcg aggatgcaaa tgaacggatt gcagaactgg taaaattaga 1894921 agaacgtcag cgaattgccc gcgatctcca tgatacgctt gggcaaaagc tttctcttat 1894981 tggtttaaaa agcgacttag caagaaaatt gatatacaaa gatcccgaac aagcagctcg 1895041 tgaactgaaa agtgttcagc aaacagcgcg aacttcttta aatgaagtaa gaaaaatcgt 1895101 ttcctctatg aagggcatcc ggctcaagga tgaattgatc aacatcaaac aaattctcga 1895161 agcagctgac attatgttta tctatgaaga agagaaatgg cccgagaata tctcattgct 1895221 gaatgaaaac attttgagca tgtgcttaaa ggaagctgtc acaaatgtcg tcaaacacag 1895281 ccaggctaaa acttgccgag ttgacattca gcagctctgg aaggaagttg tgattacagt 1895341 gtctgacgat ggaacattca aaggagaaga aaattccttt tcaaaaggac atggcttact 1895401 cgggatgaga gaacggcttg agtttgcaaa cggaagcctt cacatcgata ccgaaaacgg 1895461 gaccaagctt accatggcaa ttcctaataa ttcaaaataa acataaagga tggcttatat 1895521 gattagtata tttattgcag aagatcagca aatgctgctg ggcgctttag gatcacttct 1895581 aaacctcgaa gacgatatgg aagtcgtagg caaaggtaca accggccaag atgctgttga 1895641 ttttgtcaaa aaacgccagc ctgatgtatg tattatggac attgaaatgc ccggaaaaac 1895701 agggcttgaa gctgctgagg agctaaaaga tacaggctgc aaaattatca tcttaaccac 1895761 cttcgccaga cccggttact ttcagagagc tattaaagct ggcgttaaag gctatttgtt 1895821 aaaagacagt ccgagtgaag agctggccaa cgccatccgt agcgtcatga acggaaaacg 1895881 catctatgca cctgaactga tggaggactt atacagcgaa gctaaccctc ttacagatag 1895941 agaaaaagaa gtgctcgaac ttgtggctga cggtaaaaac acaaaagaaa tcgctcagga 1896001 actcagcatc aaaagcggga cggtgcggaa ttatatctca atgattctag aaaagcttga 1896061 agtgaaaaat cgaattgaag ccattacccg gtcaaaagaa aaaggctggt ttaaataaaa 1896121 aaggatcttg gcatctgcca ggatcctttt tgttaacctg aaattcccgt ttgagaacct 1896181 cgtcgcaacc agaattaaat tgatccatat cctcgctcct acgcccgctg aacgattgtt 1896241 tggttaacag cccaataaaa gactggattg aatgatatcc ctgttaaaat ggtcggccat 1896301 tgcacatcag cagaatttct gatattgatt atattgtatt ttcagtatga caaagttgtg 1896361 ccacttcgct cccgaagctg ccatgcccaa ctgcaagagc ctaatatcac aataaaaaac 1896421 cgtctgaaat caatccgatt ccgtaaatgg tatctgctac atccaactgc ttattatctg 1896481 ccaaaaacac cagctcgttt cgctgatcaa agatagtaac aaccagctat aaatgtcatg 1896541 atgccgaatg tctctgtaat gtggaatcaa tcttttaacc cgagagcccc tgaatcgcac 1896601 ataaagaaaa acgggaccac tttcttttat cagcatatga tataaacagc tctaagcaga 1896661 acaaaaaaag acacaagcca aaagcttatg tcttttatca caatctatat tattagttta 1896721 agactttaac acttacagtt ttgacgcccc aattagaagc atcactttta cttggtacaa 1896781 atacgtcgat tttatttcct ttaatagcgc cgccagtgtc tgctgctgtt gcttccccgt 1896841 agccttcaac atagacttta gaacctagcg gaattacatt aggatcaacc gcaataactt 1896901 tcgcgttcgg gttcttattt aagtcaatgc ctgtagctgt aacgccggaa atgccgccgt 1896961 cgttagcagt gtaagcagta gcagtaactg ttagttcttt tgaagcttct tgattatttg 1897021 tatttgattg aacagccttc tcctctgtgt taacagaagt ttctgcctca gcctttgttt 1897081 cttgtttagg ttgctgttgt acagcttctt gtttaggttg ctctttttgc acagcctctt 1897141 gttttggcgc agcttgaggt gcgtttgttt gcgcattctc agtagctgtg tttgctgctg 1897201 ttgcctgacc ttttactgaa agagttgatc cagcatagat catgtcagag cttaagttat 1897261 tccaaacttt caggttgttg actgtcgtgc cgaatttttg agcaatctta gaaagcgtat 1897321 ctcccgcttt aattgtatat tgcccagtcg tggttgtttc ttctgaagaa atggtcagtt 1897381 tttctcctgc aatgatttta tcagaagtta acttgttcca ttcttttaag tcctttaggt 1897441 tcactccatt tttctgagag attccccaga gcgtatcacc cttttgcacc gtaatttctt 1897501 ttgcagaagc gtgagctccg aatgcagttg ttgaaagtgc agcaactgcc acaaaggaca 1897561 taatcgtctt cttcataagt aaatcctccc ttgttagctt tttattggcg gctaacaggt 1897621 gatatcgtaa cacacgtaaa tgtcaaatca ataacaaaaa gatatgattt agattacagt 1897681 tcctttacat gaaggatttc tctctgatgg aaagacttgc tgaacccttg atataatagg 1897741 cttcgcaggt ctttttattt tgaggcgaaa cagagaaaat aaaatgtgtt ttttatagaa 1897801 aaaaagattg tttttctgtt tttttagtct gtcatccttg cataagcctg tatttcttgt 1897861 aaaaaaagcc ggccgtattt tgctcttttt tgttctccga ctccttttat agacaaaagt 1897921 tcatcatcat ttacgggctg ttttcctgac atttctttta acgtttggtc agagaaaaca 1897981 acaaatggcg gaacaccctg ctcagccgca atttctttcc gaaccatgcg caatcgttca 1898041 aatagctcgt cattttcagt aatcgctgcc gcttttaacg cttcttttct cgctactgat 1898101 aattctcctt tcagcacatt ccttccttta ctgctgacaa aaagagtcgg aaacgttccg 1898161 tctgacatcc tgatgaagtc gtcagaaata agaaattcga taaaatcact gatttcgcca 1898221 acggattggt gttttaatat cccgtatgtt gaaaggtcgg aaaagccgtt ttcaagaact 1898281 tttttatttt tggagccggc aagcacctgg gcaaccatcg tcttgccaaa ccgttctttc 1898341 atgcgaatga tacaagataa gaccatttgc gcctcccgcg tcacgtcatg ggccgctctt 1898401 gtatcggtac agtttccgca ctgtccgcac gcatcaggct ccttttctcc gaaatacata 1898461 aggataaaac gctgcagaca atcttccgta tgacagtagt cgaccatttg tctcagcttt 1898521 tttaaatcct gcttttgttt ctcttcatgt tctgattgct caattaagaa gcgctgcacc 1898581 ataatatcct gcggtgaaaa caggagaaca cattcactgg caagaccgtc ccgtccagct 1898641 cgtcctgcct cttgataata gctttccata tctttcggga tttgtgcatg cagaacaaat 1898701 ctgatatttg atttatcaat acccattcca aaagcagagg ttgccaccat cacttgaagc 1898761 tcatcattaa gaaatctttc ctgctgctct tttctcacat catcagccaa acctccatga 1898821 taccggcctg ccctgacctg atttcgtttc aatctctcat atatccgatc agcttctttt 1898881 ctggtcgctg tatagacaat tcctgcttca tgcctgttgt tttgcacata ttcgtctata 1898941 aaccgatctt tattttctcc ttttactact ttaaaggtta aattctctcg ggaaaatccg 1899001 gtatataccg tgttttcttt ttgaatatgc agctgtttgc aaatatcatc atgaacctcg 1899061 ggtgtggctg ttgctgttaa cgccatgatg acaggcttgt cgtgtaattc acggaacaag 1899121 atttcaatat tcctgtagct tggcctgaaa tcatggcccc attgagaaat acaatgcgcc 1899181 tcgtctattg cgaccaaagg aacatctatg ccctgcaaaa tccggataaa ctctatggac 1899241 gttagtcgct ctggtgtaat gtaaaaaagc ttataagccc cttctttgag tccgttcagc 1899301 ctctcatata tttcctgatt ggattgtgtg ctgttaatgt aggcggcgtt aatccccgct 1899361 tcttctaacg catcaacttg atccttcatc aaggaaatca acggtgaaat gacgatcgtc 1899421 gtcccttcaa acattaatgc cggaatctga tagcaaatcg atttgccgcc tcccgtcggc 1899481 ataatgcagg ccgtattttg cctcgcttcc gtcaccaagc ggatcgcttc atcttggccg 1899541 ctccgaaact tctcataacc aaaataatga gccagaaggg attgggctct atgtaacata 1899601 acgtgtaaac ctcgcttttc cttgaatttc tcccatcata tcataaaaaa gcggccttca 1899661 tttctttcac acaaaaatgg aatattcact ataccaaacc tttttagata aaataaaaag 1899721 ccatttccga aaaggaaatg gctttcgcta cgtcttgccg tatgcaagta agaaagtttt 1899781 aaaccaccac tcctcaaagt gggtgtttgc agaaacgttc ctgtcgtcct ctgcaatgga 1899841 ggcatgacat tccggcttcg atataaaact ccctattaca gcttaaaggt taaaacttaa 1899901 ttaacaatac gcacaaagta gcttctttaa tatagtacac catcaggcgc ttttaatcaa 1899961 gaggtcagaa caattgttta gaaaaacttt ttccagtgaa taaaactgtt ttttctccaa 1900021 aatacctgac aattcgacaa acaaaaaata tattacaata aaaaaaatag cctttattgc 1900081 taaaagcgaa tgattatttt cttctatatt aatgtgtata tacaaaaaga ctcctatttg 1900141 taacgatagg agtcttggct ttattagaat tttgcagcaa gatcttttgc ttcttgtaaa 1900201 cctttttcaa cgatttcttg cgcttgatca ggtgctgcgt tatgtccttc gatgacaact 1900261 gtgtgcaagt cttgaacacc ccagaaacca agaactgttt tcatgaagtt taatgacatt 1900321 tcaagtgcag ccattggtcc ttctgagtag acaccgccgc gagcgttaag aagcgcaact 1900381 tttttgccgc ccattaaacc gactggtcct tcttgtgtgt atttgaatgt aacgcctgcg 1900441 cgagacagat aatcaacata agtatgaagc actgctggca ctgtgaagtt ccaaagcggg 1900501 aatgcgaaaa caactttgtc agcttttaca aactggttca gatatttgtc agcaattgct 1900561 gcttgttttt tctcatcttc tgtcatttcc attccttgac ctgctttaaa tgttccgtta 1900621 atcatatctc tgccaaggta aggaaggttt tccttatgaa gatctaattc aaccacttca 1900681 tcattagggt tgttttcttt ataagcagct aagaaagctt cgtaaagttt agttgaaacg 1900741 ccttcttcag ctgtacggtc gcttgatttt acaaataaaa ctgtagacat ttgtattcct 1900801 cccggtaaac tttttatatt tacttacaaa tagtatgtta ctttcttttt tacgtaaagt 1900861 caatcacttt attttgaata tgagattttt tttcaaaaaa aagcaagtac atctaatatc 1900921 ggtgtacttg cttggcattt ttacttcgaa tcttgttcac gatccaagat ttcatacgtc 1900981 tgcgagcttt tttgatcaat tgtttctttg ttggataagt cttttacctg ttcatgaaac 1901041 tctctttcat aagaaggagc atctgtctcc agatcatcct ccacatcagc ttgggcctca 1901101 actgtcattc ttgcataagg aacagcttca agtctttcgt aaggaatctc ttggccggtt 1901161 ttttcacaca cgccataagt tccgtctttc atcttttgta atgcacggtt gacctcctct 1901221 aacagctccc ggtcaatctc tttcactgtt tggtctgtca tccggtctgt gacgagcgtc 1901281 ccgtggtctg ccatatggtt gtcaacccca ttggaaagct cccccacttc ttccgtcatt 1901341 gattctgttt cctttttctc gccagacaat tctttttgca tatcgagcaa tttatgatag 1901401 agatgctgtg tttgttcttt tgtcagtgcc atgtatatcc tctcctttct atcctgtttc 1901461 ccgttttgcc ttctgtcaaa catggaaaca tcgatggaaa gatgagctac tgcctttttg 1901521 aacggatcgt gaccgctggc gtcgatggtg cttcgggttt tcgttggcac tttttgtcct 1901581 tctcttctgg cggtatataa taggttgcgc ctatatttaa tctgccgctc agttcatcaa 1901641 tggtcagctc gccgaattca agatgatagt caactttttc gacattcagc gtttcaatat 1901701 gtatataggt ttcttcagac tcttgtttgc tgctttgttt ttgtttctca atcactgaga 1901761 gtctttcttc acattcacgc agtttgtcaa gttctggttt caagcaatgc ctgatcagcg 1901821 accggaacat ttttttcatg acatcacgac cctttgcata ctcctctttc gtctacatat 1901881 ataatgaggt atatcccata gaaaggagag gttttcatgc ttccgactaa catcaatatt 1901941 tctcatctca agactaactc gataggcacc ggctcatccc ttacctttgg ttctgcggag 1902001 ttaaggaaca ggtgctctgc tatcaaaaga aataacggtt ttggggaaca aaatgcagat 1902061 ggtattgtta tggtcattcc gattgaatca attgatgacc gtgatgtgtc agatgcactc 1902121 agtatgaaaa tcaatcatca ataacaatgg ttttcgcttg accttcgtct ttttgaatag 1902181 tgatgtatag gattccgtct ttaaaaatgg cattcatctt tccatgaaga tgatcggaaa 1902241 gcggaatttt cttttcaaaa cttccgtatt tcccttcttt ttggcgaaag tcctgttcat 1902301 taaaatagga aaagcgctgc cccttcacca ctaaataatc tccgtacgat aatatgtgaa 1902361 cgtcttgttt acggtagcct ggaagataaa ttaaaaactg cacttccgca acggtatcta 1902421 caatatccat gctcggaaat gaagcatctc ctttccctcg ctgatcttgc tgcgcaaacg 1902481 gaaacggaga ttggccattt gtcataaaag gggttttttg gtcttcatca aatacctgtt 1902541 tccaaaagtc accgccgtac atctgctgtg cgaattccat ccactgcttc atcttttcga 1902601 aatccatttg aagccccctg tcttaacata ctttataacc gccagcatac aactatagaa 1902661 aggaggtttg cctgtggttc aaccaactcc gtatatcaat attaatattt tcatgctgaa 1902721 aattaattcc tttgaaaatg cttcagcggt taacgtagga caaaatttat tggcagaatg 1902781 gcaaaattca gataaaaaaa atcaaggcta cggacagaat tttggagatg cgagcggatt 1902841 tatgggcacg agaagccatg tggatgacag agaccaaatt gattctccgg cctcttttga 1902901 aagtgaagcg gttaactcct caatcaaaag gaagtgatga gatgttcttt tcaccctccg 1902961 tcgtaaatgt cggcggattt aaaatcaata cgatggatcg aggttcctct ttaacactcg 1903021 gtccgtatca gcaggtcgat tactttttat cagctaaaat aaatcaaggg tttggagaag 1903081 aaaatggcga ctttactcct cttgtcgtgc cgatttcaaa tgtattagat gcagatcttg 1903141 ttgattcgaa ctcagcgaaa aacagtgtgg tgtaataaga acagggcgca catgccctgt 1903201 tcttgttttt atatataaaa aaagcctaac cattttttga acggctggct catcaaatat 1903261 tcagctgcac aaatgctttg tcagcaccgc ctgaacctcg cttaaatcgg tgtctttcgc 1903321 aaattctaat tcgaaagttt tgcttcttgt catcaataaa agcccagtgt ccggatcaaa 1903381 cattcccgct tcttggatgg caaagctttc aattgtttta tatggaagaa atacacgaac 1903441 cttcttttta gaaaacattt tattgtcaaa gaaaatgatc cgcttatttg taaagcaaat 1903501 ttggtccact cggagcttat aaatcgattc aattctttcc ccttcaacga gcaaagcctc 1903561 aagcttcttt gcgtccgttg atctgctaac agaaaaaata cccaatgaag aacccctctt 1903621 tctgcattta tctatttgtt ttatcattca ctacataaaa ataagtcctt tatccctata 1903681 taagaatacg acatagaaga catttaaacc attacgaaca gattacattt ttcaaatttt 1903741 tgatttgttt tttggctttt aagctgttgt catcaagtaa tacgcacata tagagaaaaa 1903801 agtttcaata ttcagcaatg tttttataaa aaagtggttt ttaatgattt ttttaatttt 1903861 gttttatatt tcctgtttta accacaaaaa aaccgcagct gagctgcggt tttatgtatc 1903921 gactgctttt aacaaaatct gtttgatgct tcaaggaagc attacatctc ttcgaagtat 1903981 tctttataat agccgccgac tttattcgta ttgtcgacca caaagagaaa ctcctctgtt 1904041 tcatttttta cttcatattc ttttcccggc gttaaaacgc ggtttacgat atattttttt 1904101 gcgtttgtct gcacacactt tactttttta atggtttctt tttcaagcca atttttatga 1904161 atcatgatga aatctccttt tcttatctat aagcttattg tagctttttt cttttgtaaa 1904221 ttgcaatatc ggttattcat tgattttgcc ttgatttcta ttatagaatg tttgtatacg 1904281 cttacgtttg aagcaactat cacagcttat ttctgctatt caatccagga atcaatgtgc 1904341 tatcaccaag aatctcagaa cagaccataa aaaatgactg gaggtttgtt acggatgagt 1904401 tctttaacga tgcaagtgac gaaaaggctg gagacatttt tacagggaac aaagaagctt 1904461 tatattgacg gaaagtttgt tccgagtgcc tcaggggcaa cctttgacac tccaaacccg 1904521 gcgaccggcg aaaccttgat gacgctgtat gaagcccagg ctgcggatgt ggacaaagct 1904581 gttaaagctg cccggaaagc ctttgaccaa ggtgaatgga gaacaatgtc tccagcttcg 1904641 agaagcagac tgatgtataa gctggcagac ttaatggaag agcataaaac tgagcttgct 1904701 cagcttgaaa cacttgataa tgggaaaccg atcaatgaaa cgactaatgg agatattccg 1904761 ctggctattg agcatatgcg ctattacgcc ggctggtgta caaaaataac aggacagacg 1904821 attccggttt ccggcgctta ttttaattat acgcgtcatg agcctgtcgg tgtcgtcggc 1904881 cagatcattc catggaattt cccgctcctg atggcgatgt ggaaaatggg cgcggcactt 1904941 gcaacaggct gtacaatcgt cctcaaaccg gctgaacaaa caccgctttc agctctttat 1905001 ttggcagaat taattgacca agccggtttc cctgccggtg taatcaacat catcccagga 1905061 ttcggtgaag atgcgggaga agcgctgacg aaccacgaag cggttgataa aattgccttt 1905121 accggttcca ctgaaatcgg aaagaaaatc atgtccaccg cagcgaaaag cattaagcgt 1905181 gtgacattgg agctgggcgg aaaatcgcct aatattcttc tgccggatgc gaatttaaaa 1905241 aaagccatcc cgggcgcttt aaacggtgtg atgtttaacc agggccaagt ctgctgtgcg 1905301 ggctcacgtg tcttcattca taaagaccaa tatgatgaag ttgttgatga aatggcatcc 1905361 tatgctgagt cactccgcca aggagcggga cttcataaag atactcaaat cgggcctctc 1905421 gtaagcaagg aacagcatga gcgcgttctt tcctatattc aaaaaggaaa agatgaagga 1905481 gcaaaagcag tgaccggcgg aagctgtcct tttgaagcag gatattttgt cgcaccgact 1905541 gtgtttgcga atgttgaaga cgaaatgacc atcgcaaaag aagaaatttt cggacccgtg 1905601 ctgactgcaa ttccgtacga aacagtcgat gaagttattg aacgggcaaa ccattcagaa 1905661 tatgggcttg cagccggact atggacagag aacgtcaagc aggctcacta tatcgcggac 1905721 cgacttcaag ccggaaccgt ttgggtcaac tgctataatg tgtttgacgc ggcgtctcca 1905781 tttggcggtt ataaacagtc aggactcgga cgagaaatgg gatcatatgc cttggataat 1905841 tacacagaag tcaaaagtgt atgggtaaac cttgaagact aacatgtatg tttaaaaaac 1905901 tgctgcctgc cagcagtttt tttctttctg taatggcagt aaaagacgct gaatatatat 1905961 gcttctgaag gagttgagcg tgatgggcac acttcaggag aaagtgaggc gttttcaaaa 1906021 gaaaaccatt accgagttaa gagacaggca aaatgctgat ggttcatgga cattttgctt 1906081 tgaaggacca atcatgacaa attccttttt tattttgctc cttacctcac tagatgaagg 1906141 cgaaaatgaa aaagaactga tatcatccct tgcagccggc attcatgcaa aacagcagcc 1906201 agacggcaca tttatcaact atcccgatga aacgcgcgga aatctaacgg ctaccgtcca 1906261 aggatatgtc gggatgctgg cttcaggatg ttttcacaga actgagccgc acatgaagaa 1906321 agctgaacaa tttatcatct cacatggcgg tttgagacat gttcatttta tgacaaaatg 1906381 gatgcttgcc gcgaacgggc tttatccttg gcctgctttg tatttaccat tatcactcat 1906441 ggcgctcccc ccaacattgc cgattcattt ctatcagttc agctcatatg cccgtattca 1906501 ttttgctcct atggctgtaa cactcaatca gcgatttgtc cttattaacc gcaatatttc 1906561 atctcttcac catctcgatc cgcacatgac aaaaaatcct ttcacttggc ttcggtctga 1906621 tgctttcgaa gaaagagatc tcacgtctat tttgttacat tggaaacgcg tttttcatgc 1906681 accatttgct tttcagcagc tgggcctaca gacagctaaa acgtatatgc tggaccggat 1906741 tgaaaaagat ggaacattat acagctatgc gagcgcaacc atatatatgg tttacagcct 1906801 tctgtcactt ggtgtgtcac gctattctcc tattatcagg agggcgatta ccggcattaa 1906861 atcactggtg actaaatgca acgggattcc ttatctggaa aactctactt caactgtttg 1906921 ggatacagct ttaataagct atgcccttca aaaaaatggt gtgaccgaaa cggatggctc 1906981 tgttacaaaa gcagccgact ttttgctaga acgccagcat accaaaatag cagattggtc 1907041 tgtcaaaaat ccaaattcag ttcctggcgg ctgggggttt tcaaacatta atacaaataa 1907101 ccctgactgt gacgacacta cagccgtttt aaaggcgatt ccccgcaatc attctcctgc 1907161 agcatgggag cggggggtat cttggctttt atcgatgcaa aacaatgacg gcggattttc 1907221 tgctttcgaa aaaaatgtga accatccact gatccgcctt ctgccgcttg aatccgccga 1907281 ggacgctgca gttgaccctt caaccgccga cctcaccgga cgtgtactgc actttttagg 1907341 cgagaaagtt ggcttcacag aaaaacatca acatattcaa cgcgcagtga agtggctttt 1907401 cgaacatcag gaacaaaatg ggtcttggta cggcagatgg ggtgtttgct acatttacgg 1907461 cacttgggct gctcttactg gtatgcatgc atgcggggtt gaccgaaagc atcccggtat 1907521 acaaaaggct ctgcgttggc tcaaatccat acaaaatgat gacggaagct ggggagaatc 1907581 ctgcaaaagc gccgaaatca aaacatatgt accgcttcat agaggaacca ttgtacaaac 1907641 ggcctgggct ttagacgctt tgctcacata tgaaaattcc gaacatccgt ctgttgtgaa 1907701 aggcatgcaa taccttaccg acagcagttc gcatagcgcc gatagcctcg cgtatccagc 1907761 agggatcgga ttgccgaagc aattttatat tcgctatcac agttatccat atgtattctc 1907821 tttgctggct gtcgggaagt atttagattc tattgaaaag gagacagcaa atgaaacgtg 1907881 aatcttatca agcggagatg ttcaattggt gtgaagccct gaaagatcag attcaaaagc 1907941 gaggtcagct tgaccagttt gaagatcaaa tcgacaagat gattgaggct ctggaagatg 1908001 accaaacaac agaagaagat tggtataaac aggccgctgc cctttatcgg gatattacag 1908061 aatcagatga tacaagtgaa agacgcgctt atgtccctat agggaaacac gtgctgccaa 1908121 agcttcctta caaatactcc gccttagaac cttatatatc acgcgatatt atgatccttc 1908181 atcatacaaa acatcatcaa agctatgtcg atggcctgaa caaagcagaa tcagagctta 1908241 aaaaagcgag agcgacaaag aattatgact taatcactca ttgggaaaga gagcttgcgt 1908301 tccatggagc aggccattat ttgcatagta ttttttggtt ttctatgcat ccaaacggaa 1908361 aacggcgtcc tacaggggca ttgttccaaa tgatagacct ttcatttgga agctattccg 1908421 cttttaaaga acattttacc caggcctcta aaaaagtgga aggcgtcggc tgggccattc 1908481 tggtctgggc acctcgatca ggacggctgg agattttaac ggcagaaaaa caccagctct 1908541 ttagccaatg ggatgtgatc ccccttttac cgcttgacgt atgggagcat gcctactatt 1908601 tgcaatacaa aaatgaccgg gccagctatg tcgatcactg gtggaatgtc gtggattggc 1908661 gcgaggctga aaaacgtttt gagcaggcaa aagaagtcgt ttggaagctc tattaaaaaa 1908721 agcccccttt cctcgggggc ttcgtgtgtt aaaaaatacc tatcacatgc aaaaacacga 1908781 tgatgatggc aacaggagat agatatcgaa tgagcagcag ccaaaccgca aaccactttc 1908841 gtttgagatt ggaaccgctt ttcagctcgt caaacaaatc ctgtttcggt atttttagcg 1908901 gaacaaaaat cgaaatcagt aacgcaccta acggcattaa aatattgctc acaagatagt 1908961 cagccgcatc aaaaatagac agatgaaata tagtgacgtc acttaagaca ccgtatgata 1909021 atgcagacgg cacaccgaca ataaaaatag caataccgcc taaccaagcg aatcgttttc 1909081 tcttattgat atcgcctttc gacagtactg cgaccaaaat ttccagcatt gaaaaagcag 1909141 atgtcaatgc agcaaataaa aatagaagta aaaatgctaa taaaaagata attccgaacg 1909201 gcatttgatt aaacacagtc ggcagaacgt taaataacag aaccgggcct tggtctggct 1909261 tgaggccgaa tgaaaataca gctggaaaaa tcgcaattcc ggccattaca gcaacaagca 1909321 tgttcataac agttacagat acagcggact gtaccagatt ttcctgtttc tctaaataag 1909381 cgctatacgt taccatgaca gatacaccga cacttaataa gaaaaaggat tgtcccattg 1909441 catataaaat ggtattggca tcaattgcag ttaaatcagg catgaggaaa aatttgattc 1909501 cttccatcgc gccatcaagt gtaaccgaac gcaccattaa aatgatgaat aatagaaaaa 1909561 gcgccggcat taatacttgg cttgcttttt caattccgct gcttacccct tttgcaacaa 1909621 ctaaaattgt taccaccata aagagcagct ggcctcctac agccaaataa ggatttgaaa 1909681 tggtacttgc aaatatcgta tcaaaaccag atgtttgcga taaaccgcca gtgaagcctt 1909741 ttataatata aattaaaatc catccgccta cgacactgta gaaagataga agaataaagc 1909801 acgtcaccat gcctaaataa ccgatccaat gccacttcgt tcctggagca agtgttttat 1909861 aggactgaac ggcatctttc tgtgttcttc tgcctatgat gaattcacct aacaataaag 1909921 gcagtccgat taaaaccgta aataaaataa aaataagtaa aaatgcgcct cctccgctgg 1909981 ttccggcaac atatgggaat ttccatatcg caccaagccc gatagctgat cctgccgcgg 1910041 ctaaaataaa gccgagcttc gaagaccatt gatttgcttc cttcaccgta tcactcctat 1910101 ttgatctaac cattataaag gttcattgta agaatatctt cctatatagt caagaacatt 1910161 ttaattagtt tacatcatat atctatagac atctgccaaa aactaatatt gaattattca 1910221 gaaaattatt tataataaga gaatgttatg aaatttgtaa gaatttctgc tgaagttctt 1910281 gataagtgtg ttaggagtgt ttttatggac atcattagaa aaataagcca ttttgcagga 1910341 caaacctttg gcatatgggt cattgttttt gcagtgctgg gattttcttt cccatcttta 1910401 tttacgtgga tcagttctta tattacgatt tttctcggca ttatcatgtt tgggatgggc 1910461 cttacactgc aagccgatga tttcaaagag ctggtcagaa agccttggca agttattatt 1910521 ggagtaatag ctcagtatac gatcatgccg ctcgttgctt tcggcctcgc atttgggctt 1910581 catcttccag ctgaaatcgc agttggtgtt attcttgtcg gctgctgtcc cgggggaact 1910641 gcatctaatg ttatgacatt cttagcaaaa ggaaatactg ccctttctgt tgcggttacg 1910701 acaatttcta ccttattggc acctgttgta acaccgttgt tgattatgct gtttgccaaa 1910761 gaatggcttc ctgtctcgcc ggggtctttg tttatctcaa tcttacaggc ggttttattt 1910821 ccgatcattg caggtctgat tgtcaaaatg tttttcagaa aacaagtggc aaaagccgta 1910881 catgcccttc cgcttgtttc tgtcattggc atcgttgcga ttgtctcagc tgtcgtcagc 1910941 ggcaatcggg aaaatctgct tcaatcgggg ttgctcattt tttcagttgt tatcctgcat 1911001 aacggtatcg gttatttact ggggtttctt tgtgcaaagc ttttaaaaat ggattacccg 1911061 tctcaaaaag cgattgcaat cgaagtcggc atgcaaaact ccgggcttgg ggctgcactt 1911121 gccacggctc atttctcacc gctatctgcc gtaccaagcg caatattcag tgtgtggcat 1911181 aacctttcag gttctatgct tgcaacatat tggtcaaaaa aagtgaaaaa gaagcaagct 1911241 ggatccaaaa gcagcaatct atcactttaa atatgcatca aaaagggtac atcactttat 1911301 cgtgatgtac ccttttttat tatccttcta ataaaagctg ttcaggatct tccagtaaat 1911361 ttttgattgt cacgaggaaa ccaaccgctt ctttaccgtc tacaattcgg tgatcataag 1911421 ataaagcgat atacatcatc ggacggtttt cgaaacgctc ttcatcaatg gctacagggc 1911481 gcagctgaat cttatgcatg cccagtatac cgacttgcgg gctgtttaaa attggagttg 1911541 acatcaatga accgaaagtc cctccgtttg taatcgtgaa ggagcctccc tgaagctcgc 1911601 taagggttaa tttattgttt cttgcttttt tcgcaagctc gccgatctct ttttcgattc 1911661 ctgcaaatgt caggcgatcc gcatcccgta caaccggaac gacaagacct tcatcagcag 1911721 caacagcgat tccgatatcg tagaattttt taacgatcaa ctcatcgcct tgaatttctg 1911781 cattcaacag cggatatttt ttcaatgcag ccacgaccgc tttcgtgaag aaagacataa 1911841 agccgagctt cacttcattt tgctcaaaaa attgatcttt gcggcgtttt ctgagattca 1911901 tgacagccgt catgtccact tcattaaatg tagtcagcat cgctgatgtt tgctgtacct 1911961 ctacaaggcg ttttgcaatc gtttgtctgc ggcgtgacat tttttgcact tcaacaggtt 1912021 tgtcaaagct ttgctgtgct ttttgagcct gaggctgctg cttttgctga ggagccggtt 1912081 ttgatgccgg tttttcgtac gcttcgacat cctgcttgcg cactcttcca agcggatctc 1912141 cagttggaac ttgagacagg tcaattcctt tttctctcgc aagcttacgg gccgacggag 1912201 aagcgatcgt tcttgatttt gcttcagatt gtgcttcctc gctcacctct tgtgcagctg 1912261 gttcagcctg tttctcttct tttacgcttt ccttgctttc tgttttctct gtaggagcag 1912321 gggcagaact ttcacccgcg ccttctgaaa tcgtaccgat aatttctccg acctggacgg 1912381 tatcacccga atctttcaat acctcttgaa gtacacccga ttcttctgct gtcaattcaa 1912441 cattcacttt atccgtttct agttcaagca gatattcacc ctgttctaca tagtcaccag 1912501 gctgctttaa ccattgggct attgttcctt ctgagattga ttctgctaat tcaggtacct 1912561 taatttccgc cattttttca tttccccctt agtttttgcg agtcaagcta tcagatacaa 1912621 tacgttcctg ttctttttta tgaactgtcg gatctccctc tgcagggctg gatcgtcttc 1912681 ttcgtccaat atattgaacg cttactccct ctggtgcaat ctctgtcaaa tacgggctga 1912741 tataacccca agcccccatg ttctgcggct cttcctgcac ccaaacgatt tctttcaggt 1912801 tcggaagttt tgcaaataat tctttgactc cttttgccgg gaatggatac agctgttcga 1912861 ttctcgcaat gtgaagccac tctttaccgt cttctaactt attaaaatga tcgctaatgt 1912921 ctatagacac tttaccgctg gataatacaa gtctggttac tttttcatag tcatgagaaa 1912981 gtcccgactg ttcataaaca ggctggaagc ggctttcgct gagctcctgc acttccgaca 1913041 ccgtatttgg gttgcgaaga aggctcttcg gcgtcataat gacgagcggt ctgatttctt 1913101 cacgaagcag cattttagcc tgtcttctta aaatatggaa atactgtgcc gcgcttgtca 1913161 ggttggcaac cgtccagttg ttttccgctg caagctgcag gaatcgctca attcttccgc 1913221 ttgagtgctc aggcccctgt ccctcgtaac cgtgcgggag cagcatgact aatccggatt 1913281 tttggcccca tttcgcgcgt ccggcagaaa taaattggtc aaaatacact tgagcagcgt 1913341 tggcaaaatc tccgtactgt gcttcccaca aaacaagcgt ttccggtgaa tgcacgttat 1913401 agccgtattc aaaaccgaga accgatcctt cagacagcgg gctgttatga acagcaaatg 1913461 atgtgctgca gtcagataag tgatgaagcg gcacaaattc tttgcccgtc tcactgtcat 1913521 gaagcacaag gtttctttgg gcgaacgttc cgcgctcgga atcctgtcct gttaaacgaa 1913581 tcggtgttcc gtctttcaaa attgaagcaa acgcgagtga ttctgccaaa gaccattcca 1913641 cttttctgtc atcatcgaac gccttggcgc gtctttctaa aatgcgcttt agcttgccga 1913701 aaacattaaa tgactccggc cagttgatca attcgccatt cagcttgcgg agcacatcaa 1913761 aatcaatcga agtgtccaca tctgggaaac cgtttgatac aggctctgga agttcaattt 1913821 cacaagcagt gtgttccttt ttagacggaa ctttctgata tgcatcctca atgcgcttcg 1913881 ttaccgattt ttcgatgttt tgaacgactt cctcggtaac cacgccttct tttaccagct 1913941 tttcagcgaa aatttgtttg acggtcggat gctttctgac agcatcatac agcattggct 1914001 gagtggttga cggttcatcc atttcgttgt gtccatagcg tctgtacccg atcaaatcaa 1914061 tcagaaaatc cttgttgaat gtttttcggt attcgaccgc aaacttaaca gctgaaagac 1914121 aagcttcagg atcgtccgca ttcacgtgaa caatcggaat ttcataaccc ttggccaggt 1914181 cgctggcata ttttgtcgat ctggattcag cgctttctgt tgtgaatccg atcatgttat 1914241 tggcgataat atgaatcgca ccgcctactt gatacccttt taaagagctt aaattcaatg 1914301 tttcagctac aattccttcc ccagggaatg cagcgtctcc atggattaaa atggccagcg 1914361 attttgtttc atcttgtacc gggtatccgc tttgtgttcg cgtttcctgt gccgctcttg 1914421 tgctgccttc aacaatcgga ttgataaatt ccaagtggct cgggttgttc gctaacgtaa 1914481 tgcgcgctga ttttgtttca gcgtcttgaa gctcccgatt cgcccccaaa tggtatttga 1914541 catcccccgt ccatccgtag ctgattccaa tggatccctc agacggtaca agatctttgt 1914601 tcggcgcatg ctggaattca gagaagatga tttcatacgg tttgccgagc acatgtgcca 1914661 agacattcag gcgtcccctg tgcgccatcc cgatgttgac acttgtcgtg cctgatttga 1914721 cagattgtgc aataatgtca tcaagcactg gaacaagagc gtccagaccc tcaatggaaa 1914781 agcgcttctg cccgacgaat gtgcggtgca aaaactgctc aaagccctct acttctgtca 1914841 atctttccag cacagctgac agcttttcag ctgagttctt ctggaacagc tcgccagatt 1914901 caatctttct tgtcagccac tcgcgctctt tgaagtcatg cacatggtca aattcaaaag 1914961 agatggttct tttatacgta tttcgtaaat actgaatggc ttctaaaccg ttcgaaatgt 1915021 ttttaggagc gtctttgcag atgacagacg caggtattgc ttttatttcc tcttctgtta 1915081 gcccgtaatc ggataatgga aaaagttcgc tctttttctc atcctttctg agcggattga 1915141 cggaagcgtt caaatggcca taggttcgga tatcttctgc aagtctgact gcggatgcga 1915201 tcttttgaat cagatcggct gtaacacgtc ccttttcttt tgttcccgag gcctctttta 1915261 tatcgcttgg cggagcaccg agctcgtcga acatttcctt caaatccggg tcaatgctgt 1915321 tcggatcctg ggtatactga tcgtaaagct ccagcgcata gccgaggttc ggaccgtaaa 1915381 aatcttccca attcattcgt tgtttcatac tattttgaaa catttgaata ttacccccaa 1915441 cttaaataat caagtgattg attcactatc ttgaaataac tttcgaacgc tgtgtccaaa 1915501 attatgtaat aaaaacgctt ccaacgatat tttaccactg tttgcaattt gattctacct 1915561 tgattgttca caaaatagta aaaaaccttt ataaaaaaca aaaaatttaa tcattcgaaa 1915621 aaacaaacgc caaaaagcat aggattaagg gctatcctat gcttttatga agcagttttt 1915681 tcagcagcgg atacaaaaca tccggtagct gatcaacatc cgggacaaat atactgaatt 1915741 ttccgtacat atcctggatc gtcttcattt gcgattcttc tatttctgag ttggagagaa 1915801 aaacatttat cacttctatt cctctttttc gggcttcgat aaccgcctca cttgtatcaa 1915861 cgatcccatt ttgttcgtag ccaaatgcgg ccggctctcc atctgagaaa acaattaaga 1915921 acttttgcgc ctcgctgcga tgcagcattt ttttcgtcat ctgcctaatt gcgtacccgt 1915981 cacggttatc ttcttctggc tcaagctgca taatggccgg tccagaatct tgtcttaatg 1916041 atgattggaa gggaataacc gtattgaaat agtttggctg gcttttttcg gttgcatcat 1916101 ttgtgtcctc ccaaaaaccg acaatctgat gcggaaccgc taccgatttc aacgcttcgt 1916161 gaaacagcac gattcctcgt tttgtttcgt ccattttgtc gaacatgctg gcggaacaat 1916221 cgaccagcaa tgtaaaaact gcgtcgattt ctgaagatgg ttcttgcttt ttgtagaaca 1916281 ggcgcggatt tcgctcagtg aagtaacgaa gaagcttatt gttcagtctc ccggcatgaa 1916341 ggtctgttct cggcaatgtt tttttatgct ccagcgtttt ttgaatcatt tgtttcaaac 1916401 gcttttgata cgattcaatc gtttttgcct gctgtttata agaaagctct tcttcactgg 1916461 ttgccggctg cggttcttta taaattggaa atgcatattt attttctttg ccgtcagcca 1916521 tacccgctcc gttcggctgg tctttttggg actccagcgc ttccagcttg gaatagtctt 1916581 tccgtttcgt ttgtctggct gatccttgaa cagagccaag ggcctgatct ccatcgtcgc 1916641 cttcccttga agcatctttt cctaaatctg attttgcgcc gtgttcaata tcaaattgaa 1916701 ggaagctttt agacggtgct tctgtttccc ggtgccatgt cggcatttct tcttcatgga 1916761 tatcctcatc accgtctgat tgttttggaa gcgtgatgtc atcactcagc ttcggcgctt 1916821 ttttctcttc ttcaaataac ggctgttctg cagcttttgc gtaatcaagc tcaggcaaaa 1916881 agaagtaggt gttcaacatg tctttatcga gtacctcttc aagtccgtcc atgaggtcct 1916941 caacaatttt cagaacctgc cgtgtcgaat ctgcttcata cacacgcaag agctgctgct 1917001 caataaacgg gcgcatcaga tcgatatctt cacgcatgga tggaagggtc tcgagcggcg 1917061 attccgctgt gagcttgaaa tagatcgcgc aaaagagcgc atcggtaaaa atgcttcgtt 1917121 ccaaatttaa ggtcagctgg gttgagaaat gttttctgta catgtctttt cgcttcgcaa 1917181 atacatgttt cgtacccggg cgctcacgtt tgatgcattc ttcgatccta atgtcttcaa 1917241 gcagcataaa gagctgcttg gcaaaacttt taaacgtaag atggcgatgg atatcattca 1917301 aaaagttcgc aaactcatgc agcgagctat atcttgttcc gactgaacgc aggtagacgt 1917361 cgcttttcag acccgcttcc atgtcctcag ctgccctgtc tttccaaaag tggctcatat 1917421 agattttctt ttcaaatgga ttgtaatagg actgaacgcc atactccact tctaccgctt 1917481 cactcttggt gagtgttttg gccaaatcag tcagcatcat aaataaaaat gaatcaatcg 1917541 tgctgtcgtt aaatttgata aatttcatcg cagccccctc attcaaacag agtttctgca 1917601 atatttcgga cagccgcttt ttcccgatca tcatcaagct tttctacaat tccccgctca 1917661 atggcacgac gcggcggaat ataagcagct aaatcacatg tatcgattaa agctctgatg 1917721 gatgccgctt cttcagacac ctgtccgtta ttggcctgaa cgatcaagtc agaggaaagc 1917781 gtgataaatc tgtcaatcaa tttctcgtct ttcaaggctg actgagacat gagcacttgt 1917841 ttcagcagct cgcctttaat ataaggcaca tcaatgatga caaaacggtt tttcaacgct 1917901 tcattcagag gaacagttcc gacatagcct tcattgatgg ctgcaatgac tccgaaaccg 1917961 cttttagccc gtatgacctc gcctgtaaac ggatttgtca tcatttttct gtaatctaat 1918021 acaccgttta gaataggcag tgtttccggc ttcgccatat tgatttcatc tatataaaga 1918081 aaatggcctt ccttcattgc ctttgtaaca ggtcctgaaa caaactcgat tgttgcctgg 1918141 ccagattgat tttcaatcgt tttataaccg accaatgcct cagcgtccaa gtcgactgaa 1918201 cagttgacgc tgtgcatcgg tttatgaaaa tagctggaca atgtttctgc cagctttgtt 1918261 tttcctgaac ctgtaggccc tttcagcagg acatttttcc ccatggctaa tgcaataatg 1918321 gcgtcaaata aaatggcttc atcctccgcc tcatagcctg atgttcctat aagcgattga 1918381 aactctgggg aaataggctg ctctttatat gataaaagct tttgttgtat atcttccggc 1918441 aatgttaagt gctgtagttg agttgtcata gacagattcc ctttcctatt catattccat 1918501 taacgagtat actaaaaaag cccctgtatg ctcaatacaa aagggcctgg atgatattac 1918561 tgcttctcgt tatttcccaa aagggctccg cagacaatac gcgcaccgga attgccgctt 1918621 gggtttgtca gataatcgtc cgcttgttca tgaataataa atgcacttcc gtcctcgtcg 1918681 agaatattta gtttacttcc ttttttcagt gaagtgtcag gcgcattcat tatgacatct 1918741 acctttccat cagcaccgac ttcaaggttc ggcagatctc cggcatgatg ccccatcgga 1918801 ttattaaagc cgtgttcttt gttcagtgga ttaaagggac cgcccgctga ttcaaaatcc 1918861 ggcctgacac aagaaccttt ctcataaata tgaaaaccga gagaagcacc tggacgcagg 1918921 ctgtttgcgg aaatatgaat atcgaggcct tcatcatctg attctttgat ctctataaaa 1918981 ccgactgctt tcccttcacg attgaccagc tggacatgat gaccaaacgc tgacgtttca 1919041 accacttttt tttccggcac ccggttagga gggtctggag gttttttttg tccgcatccg 1919101 gcaactccca gtgccgtcag catcatcaac agcaagagac ggtgcatact gtctccccct 1919161 tgttttttct aacagtgtgg tcaatcattg tctggtataa acaaaaaagc ctataaaagg 1919221 ctttttgtca tactcatttt taaaaataac ttcttgcgcc caagtaccgc tgtttccaat 1919281 acgaattgct gagattggaa atgtcgacgc ccgatgagct tgcatgaata aaatcaccgc 1919341 cgcctagata aatccccatg tgagacgggc cggatttata tgtggtaaag aagacaaagt 1919401 ctcctactga cggctggctg actttctgca tgacattcca ataccctgcc gtactcaatc 1919461 ttgatataga tgatacatta ttaatgaggt aataaatgaa gccgctgcaa tcaaaaccgg 1919521 caggcgtgtt tccgccccat cggtaaggca ctccgacata ttttttcgct tccgttatca 1919581 ttctgtcaat cttcgaacct atttgaatgt ttgaccctga gttatctttt ggctttgttg 1919641 gctttgtcgg atttgaagga ttagattttg atgctcccga aatagtcaga acctgcccga 1919701 tttgcaacac atccgatgat aaattgtttt tatcacggat gctttggaca gtgactccga 1919761 gccgatttgc aattttccac agcgaatcgc ctgcttttac cttgtacgtc gttgtttttg 1919821 agggattgga gtttgacggc tttttggaac cgctgtttcc gttcttaggt gaactgcttc 1919881 cttttatttt gagcacctgt ttaggataaa gtgtatctga tgttaagcca tttaaggttt 1919941 ttaattcggc tacagtcata tttaagctgt ttgcgatttt ccacagtgag tcaccaagct 1920001 tgaccgtata tgtacttttt gaagaacctg aagaattgga accgctgttt ttctttgatc 1920061 catttgatcc gcttgaactg cttgtccctt tgatcttaag cttttgcccc ggacgaatca 1920121 ggtcactgct caggctgttt aagcttttaa gctcagaaac actcatttta tgatttttag 1920181 caatcatcca tagggaatca ccatatgcaa ctgtgtatgt tgatgttttg cttgaattag 1920241 atggggatgt cgtgcttttt ttgctgcttt caggaacctt aagactttgt ccgacataaa 1920301 gcaccgttga tttcaatttg ttttcggatt tcagagctga tattgtcgta tcatactggc 1920361 gggaaagttt ccaaagagag tcaccgcttt ttacttttat cgtttttgct tccgcgggtg 1920421 ctgcggccat cgacgaccca acaactgcag aaacagccaa gccggctaca atcttctttt 1920481 tcattcattc aacctcctaa actgtttttt tgcaaaaaca gctagtattt tgtttccaaa 1920541 aatggcacac aactgtttta tcgtcaattt ttcagcaagt taaacccttt tcaaacattt 1920601 ggcgcagcat tttcagcatc gttcgacctt taaaccttca aataaacatc taacatttta 1920661 cataagcacg atatgttttt cgaaagtcta aggaactatt taagcgaggg taaaaatgat 1920721 ggttttctat tgatgaacga agcagtttct cctcctttct tgtctatttt tctaatcaat 1920781 tctctatcgg cgtgtcaaat cccttcctct gcattcttat gaaatggcaa aaagcctgtt 1920841 ctttcgataa gaacaggctt ttacactatg catttgctga ttgagttttt tgttttacag 1920901 cttcaagaat gctgtcggct gcttttttag agccgcctgc cgctttcagt gattgtccaa 1920961 tttcttttgc cttttcagca tacgaacgat tattcattac ttcttgtatc gtctctttca 1921021 gtaggctttc agacaattct tcctttttaa ttacttttcc tgcgccgact ttttctacct 1921081 gatctgcgac aacaaattgg tcgcctccca tcggaatgac aacgagcggg gtttcaaaat 1921141 acaaaccttc acttgtgctg ttcattccgc cgtgggtcac aaataagctg gctcttttca 1921201 agatctcaag ctgagggaca tacgggcgta caatgaaatt ctccggaatg tcgtttaact 1921261 cacttgtttt aatatgcttg ccgatggaaa gcacaacttt accgtcaaag tccttacaca 1921321 cttcaaggca ttgattaaaa aactgctttt gattattaaa aatggttccc attgaaataa 1921381 acagcacgtt ttcattgtca atctgatcaa atgggaaatc attgtttccg gctctttctg 1921441 taatggaagg accgacaaat acatatcgct cgccaaattg ctcagccagt ggctgaaatc 1921501 cccttgatgt aaagacgatt gtcaagtcac catcagctaa aaaaacatca aatggcttct 1921561 tgatctctgc ttgaaaatca gcatttaacg tttctgcaag ctgctggtat gattcataat 1921621 gaggcgaatc ttcaagtgat cctttcatgt acgctcccat catttccttc gcaaattcct 1921681 cattcatcgc aaaggttgta cacaatgaaa atcttggcag cttcagcatg ttggcaatga 1921741 ctttacccgc gagaagatgg tgatcatata tgacataatc atacgattca tgtttgactt 1921801 cctcataaat atgagtcgcg atatccttac aggctttcaa aaaagcgcag agcatttctg 1921861 tgaaatctct ttcttcatcg ccggttgcgt ttttcccgaa gtaatctcct ctgaaatcat 1921921 gatactcacg aaactctata tcaagagctg tgattttttc tttatattcc ttcactgcgt 1921981 agtacgtaat gttttctccc cgggatttca gctccttcat cacaccgata gagggattaa 1922041 tatgcccttc accggggaaa ccgatcatta atacattagc catgcggcag cacccttcct 1922101 ttgagaattt atgtaatatt ttatacggta ctataaatgc ataaacaggt aaagtatttc 1922161 acttaattaa tattcatcat atataacttt tctaccagtt tatattccct gtcttcaaga 1922221 caaaaagcat tcagcttgaa gcgaatgctt taataaagat gcgaattcag tcattttgtc 1922281 tcatgatagg attcttaatc aggccctttt tattattttt acgttcttgg tgaaattaac 1922341 ggatataata caccgtcttt ggcaaacgac atcttccctg tttcctctga aaccacgagc 1922401 accagtgcat ccgtatagcc cgacatacca agagccgccc ggtgccgggt tcccaaatgg 1922461 atatccactt ccttcgtcgt cagcgggagc acattggctg ctgacacgag tttgttttcc 1922521 ctcactaata aagcgccgtc atgaagaggg tttccgggaa aaaagatgct ttcaattaat 1922581 gaagagctga tctcggcgtg tagggaggtg cctttttgaa taaaacgttc aaccgggtct 1922641 gctctttcaa tcacaattaa agctccatgc ttatgttccg ataaggcttt aatcgccttg 1922701 gccagctcaa taaatgccgg cgtaaattcc tcaatgtatg attgcaaata aaaggaggat 1922761 gcaatcccct gcatgtcctg aaaaacgtgc cccaaatcat ctaattcaca aaggagacac 1922821 tggtcttttt cgtgaagcgt tttcaagatt agagatgcat cacctaatat ttgctctaag 1922881 tacacctgta ttttcccctt gaacgcattt tctgatatct gctcatagcg catagccttc 1922941 atctcctgtt taaatttcca acttttcacg aatgcttatc ttattgatgc acattctatt 1923001 ggtaaaggag ggatgtaaag aatggaaatc gaaagaatca ttcagtatat ttgcaccttt 1923061 ttaggcgtga tttcgctttc ttttatttat gcccaaatgt ttagaaaaac gaaaccgaca 1923121 aaaaaagaat aggcccggcg ttcattgctt tttatacata aaatgttata atttctctcg 1923181 ttatgaaaaa gaaacggaga tcaatgtatg aaagaaactc aaaacgcccg ggaaaaaatc 1923241 aaacagctct tgcacatttt aataccgata ttcattaccc aagcggggct ttctctgatc 1923301 acttttctag atactgtgat gtcagggaaa gtcagccccg ctgatttagc tggtgtcgcc 1923361 attggctcaa gcctttggac ccctgtttac acaggacttg caggtatatt aatggcggtc 1923421 accccgattg tcgctcagtt attaggtgca gagaaaaaac agaagattcc ctttactgtt 1923481 ttacaagctg tatacgtggc cgcgcttctt agcatcgccg ttttagtgat tggatatgct 1923541 gcagttgacc ttattcttgg ccgattgaac cttgatattc acgtgcatca gattgctaaa 1923601 cactttttag gctttttatc actgggaatt ttccctttat ttgtttacac cgtgttgaga 1923661 tcattcatcg actcattagg aaaaacgaga gtcaccatga tgattacact cagttctctt 1923721 ccaatcaatt ttgtattgaa ttatgtattt atcttcggga agttcggaat gccggcactt 1923781 ggaggtgtag gcgcgggact ggcatccgcg ttaacttact ggtgtatatg catcatcagt 1923841 tttttcatta ttcataaaaa cgcaccgttt tctgaatacg ggatttttct taccatgtat 1923901 aagttctctt ggaaagcatg caaaaatttg ctcaaaatcg ggctgcctat tgggttcgcc 1923961 gtgttttttg aaacgagcat tttcgcagct gtcacgcttc tcatgagcca ttttcataca 1924021 gtgaccatcg cgtcccacca ggcagccatg aattttgcgt ctcttttata tatgctgccg 1924081 cttagcgtgt ccatggctct aacaattgtt gtcggatttg aagcgggtgc agcccgtttt 1924141 aaggatgcac gctcatatag cttaatcggc atcatgatgg cgatcggctt ttctttgttc 1924201 actgccgcct gtatcctttt attcagagag caaattgcgg gcatgtacac ttctgacccc 1924261 gatgtgctcc ggctgacaca gcacttttta atttatgcgc tattttttca gctttccgat 1924321 gctgttgccg caccgatcca gggagcactc agagggtaca aagatgtgaa ctatacgctt 1924381 gcggccgctt ttgtctctta ctgggtcatt ggccttccgg tcggttatat ggtcggtacg 1924441 tttacaagcc tcggtgcatt cggctattgg attggattaa tagcgggact cgccgccgga 1924501 gcagttgggc tgtttttcag gctggcaaaa ctgcaaaaac gttattcgca aaaacaacac 1924561 atttaaaaga ggtgatcaat catggcaaaa aacaaaaaat tattcgagta tctttcccag 1924621 catgcggaaa ccatcagttc aacatggtat gaaacaatcg aggagactga tcccaattcc 1924681 atttatgcct caacagaccc tgttgtcatt cacaatttaa agagccagaa tcttgccttt 1924741 aactataaaa taaaccgtat ttttatagat gatgaggacg tatacttgcc tatactgaaa 1924801 gaatgggcct ttgaagtcac acaggatcaa gagcatttaa aaactcctat ccactatatt 1924861 attcgggagt ttgtcagagt gagagattta tatgtttctt atgtgaaaga atttgtccat 1924921 ctcaatcaga atactgtgaa aagcgaagaa gccgaagacc tgtatcacgc ccttataaaa 1924981 gcgtttgatc ttgtgattca tatttttata gaagaaatgt acaaaaacac aagccttcag 1925041 cttcaggccc aaaaagatat gattactgaa ttgagcgctc cggtcatcgt gctgtttcac 1925101 agcgtcggac tgctgccttt aatcggagat attgatacag tccgcgccaa gctgattatg 1925161 gaaaacacac tgcatcaatg tgcgaaaaaa aaggtgacac aactgtatat tgatttgtca 1925221 ggagtagctg tgattgatac gatggttgcc catcagctgt tcagtctgat tgaggcgctt 1925281 cgtttaatcg gtgtttcttc aactttgtct ggaatccgtc cggaaatcgc gcaaacagcg 1925341 gttcagctag gtttgtcttt cgaaggtatt tccttgagat ccactctcgc ttcagctatt 1925401 gcatcggact taaaattaaa aaaggtataa ggcttaaggc cttatacctt tttgattaat 1925461 cattccattg atacgtccaa tatatttctt cttcaaacca tgttgccata acaggttcat 1925521 tatttttcaa tttctcttca agctctctga gcatgccttc tgtttgtgtg cggtgagctc 1925581 ttaacgcatt cattttaata tcagctactt ctttgatatc aagtacgaca tcagcttcgc 1925641 cgagaacctc ttctctgttg cgggtaatgg ccatgcagat tgtacgcgga cggtcttctt 1925701 tctttttgcg gtataatgca cggataaccg cttccccgca tgcatcatgg tcagggtgca 1925761 caccgtgtcc gggataaaat gtgacaatta aacttggttt tacatcatct atgatctctt 1925821 ccatgatatc agctaaatac tcatcgtctt caaattcgag cgttttgtca cggagtccaa 1925881 gcatccgaag gtcattgata tccatttctt tgcaagcgtt gatgagctct tgttttctta 1925941 gcagcggcaa cgtttcccga ttcgcgaaaa atggatcgcc catatttctg cccatttcac 1926001 ctaaagtggc gcaggcatac gtaacgggaa tgtctttttt tctgtttaag gcaatgaggc 1926061 ctgccactcc atatgattca tcatcagggt gaggcaggat tactagtaca tgttctttca 1926121 ttattattca cccttttctt taaactgtga acggtttttc gctgatttgc agagaaatag 1926181 ccagtttacc gcccggcagg tgtcccgcca ttaataaacg gttttcttca tctaccgtgt 1926241 attcagtcaa gccttcagca taaatccagc cttcttctgt tttcaagcca acgcggtaag 1926301 gcccgttgcc tttgattttt gcctgatgat aagtgacttt tgcattgcga atatacgcaa 1926361 caaccgtcat gttcttttca tttaagtgcg ctgaataaga acctgtggtg gtttctaaat 1926421 ggatatatac agggcggtcc gcatatcgtt ctaaagatgc ttgcacatct tcttttatga 1926481 tcgctttcat gattgctccc ctctttcttc ttttaaatac tctgcacgtt ctgtatgtaa 1926541 tttgaccagc tgatatttca cagccggttc gagctgtgaa ttcacaatgc gctgaatcgc 1926601 ggcaaaatat ttttccagca tcggttttcg gagtcttgga tgtgttcgtt tatccaagag 1926661 ctcaagatca atcgcctctg ctaccgcttc tgcgtcatca tgtgcgagag atcggttatt 1926721 ccaaagtgaa gcataggctt tcactatctc tttatcattg tccatcgtct tgctccttta 1926781 tgtcttacat acatgaaatg attatacata atatatgcat cagctgaaaa gccaaaggcc 1926841 tcaatggctt tttgacgccc gtttccactt cacttgtgaa aacgtaaaca agagcagcgc 1926901 agcccatata cagctgaatg taaaagcctt cgagcttgaa aatggctcat ggtaaacaaa 1926961 cagcccgatc agcagggtaa tggtcggcgc aatatattgt aagataccga cttgatacag 1927021 tggcagccgt ttcgctcctt ccgcaaacaa taagagcggc aaagccgtaa acacaccggc 1927081 caaaaagaga agcagccacg tccctccgct ttctgcaccc gctggctgaa catgtccgct 1927141 gaacagcaaa taccccaatg caatgggcat aatcatgaat gtttccagcg ttaaaccgat 1927201 ggcgctcggc aggcttgttc tttttttgct taacccgtac agcccaaagc tgaatgcgag 1927261 cagaagcgca acataaggaa tggagccgta ttggaacgcc gagatgatga caccggctgc 1927321 cgcaatcgaa acggccacta attgcaggcg attcagtttt tcctttaaaa ataaaatccc 1927381 aaggagcact gatacaagcg gattaatgta atagccaaga ctagcctcaa gcaaaaagcc 1927441 atggttgaca gcccatatgt atacaaacca gttgatcgaa atcaggatag aagcaagaaa 1927501 taaagagagg atccctccgt tctttttcag agagcgcaac tcctgccatc ctattttcca 1927561 ttgccgcaag aaaaaaagta cgatacacat aaaaacaaaa gaccatataa tacgatgagc 1927621 caaaatatca agagccggca gctgttcgag aagcttccaa tagagcggaa acaggcccca 1927681 catgataaat gaaacggctg tgtaaataac gccttttttt gtttctgcat gttgcattga 1927741 tatccctgcc tttctttaga gcatcttata ttatatcacg tgaaagatct ggtgggcata 1927801 tactattttg tccgtgaaga aaggatgtga agacaatgtt tgagtggaac aagtactttc 1927861 ctttccacaa tcaattttct aaagaagcat taaaaaaagc tgatccgaaa gaagttgaaa 1927921 cgtatgtcaa tcgtgtgatg gaaagtgtgt tcggcagtga ttatgcggct caatttcctt 1927981 tccgcgatcc tctcccccaa aaagaacatc ccgccaaacc tgatgcaaaa cctgatgtca 1928041 aacctgatat tgatatattc gaaacagcag accatgtgtt tgtaaaggtg ccaatcagcg 1928101 aagaatggct ggaacaagtg agaatcaaac acacatctca cgaattatgg ttggaaaacc 1928161 tcccaagagc agatcatccg aaaaaagtaa accttccttg tttagtcaaa cgcaaaggaa 1928221 caaaagccgt ctataaggat ggccttctgg aagtcatgtt tcaaaagcag caagactaca 1928281 atatgtccga ggtagaaatc atccgataaa aaacggcctg caatcgatgc aggccgtttt 1928341 ttattaatag aagccgggat atcccccgta tggcacgccg gcaccaaaac cgtacggtcc 1928401 gcctccatat ccataagggc caggaggata ggcataggga cgagaatagt taaacagcgc 1928461 actcccgaga aaaccgccta ataaaccgcc gactagagga gcgccaaaca aaaaaggact 1928521 acgcgccgga tatccggctg gacctgggat tccgcgtaaa tacgaatgat gagggtacat 1928581 gattttttcc tcctttatgt ctgcctatac gtaaagtatt cagcaaggaa gaaaaacgat 1928641 tgggctacgg actgtctatg attgttacat cacaagccct gccaataaca cacagccgag 1928701 ccctgtaacc gaaagaactg ttgtaagcag cgtccaggtt tgaaatgttt ctttcatgct 1928761 caagccgaaa aattccttta ccatccaaaa tcctgcatca tttacatgac acgcaatgac 1928821 actgccggct cctgttgcaa gcaccattaa cgcagggttt acactgccag cctccataag 1928881 cggagctgcc attcccgctg tggtaagcgc agccacggta gcagagccta gacacagacg 1928941 cagaaccgcg gcgatggtcc atgcaacgaa tagcggcgac atgtttgttt gacggaaaaa 1929001 atcagcgaca taatcgccga ctccgccgtc aatcagcacc tgtttaaacg ctcctccccc 1929061 tcctatgatg agcagcatca tcgcaatttg cgaaattgat tctgaaatag atctgccgat 1929121 ttcctgcata gatattttac gggcatatcc catcgtatag agtgcaagca acagcgaaat 1929181 gagcattgcc gttcccggag tgccgataaa ttctataatg tcttttcctt ttgaatgttc 1929241 actcaataat aaagaaaaaa ttgttgccat tgccataaag ataaccggga ataaagacgt 1929301 gacagcactg atcgcaaagc ccggtgtttc atccagctga aattctttcc ttggtcctaa 1929361 ccccgatagg tttccatgct tttgatacgc accaggaaac cgtttcatcg caaatttatt 1929421 aaataaaggc ccggcaatca cagttgtcgg aacagcgatg atgattccaa aaagcagcac 1929481 ctggccaata tgggcaccat atgcaactga gatagcagtt ggagcaggat gcgggggcaa 1929541 aaatccgtga gtaacattta aggcggcggc catcgggatt cccagataca gaaaaggcat 1929601 ttttaattct ttagcaatcg cgtaaacaat cggtatcaac agaacaagac cgacttcaaa 1929661 aaatagggca atcccgatga taaaagaggc aaccacaacc gccgcctgta ttcgtttcct 1929721 cccgaatttg tcaatcagcg taatggcgat ccggtagccg cccccagcat ctgagacaag 1929781 cctcccaagc atcgcgccaa gtccaaacac taaagctaaa tgccccagct gcccgccaat 1929841 tccagtctca attgaaagaa caattttatt gatatccatt ccaagtccga tggctactaa 1929901 aaatgaaacg acaatcagtg agacaaaggt atttaatttt actttaataa tgagaaataa 1929961 cagaatcagc actccgacag ctacaattaa aatcggcatg gtacccctcc aaaagtgttt 1930021 tatatgattc tcgcgacaat gttttggcgc ttttcatgcc tagatgaaca gaaagcgctt 1930081 tcattaataa ctaaaaacgt cttggttata tgattgttat cttttgatca actaatatgt 1930141 tcatactaat ctcctaatca atgactgtca atcgttttta tgagcttgtc tcgattacct 1930201 accgcctaac ccaatgattt attagttata tgttgattaa cttttggtta tatgttatgt 1930261 tttttaaagt tgactgccaa tcattatatc tctccattgt ctggaagcaa atgagacaat 1930321 atgagaacag acggataaca acttcataag aggaggagta cacatgccat tattgcgttt 1930381 tgatgtaatt gagggccgtg atgaaaaatc gctgcaattg ttattagata ctgctcacca 1930441 agcgatggtt gaagcatttg gtgttccgga aagagaccgt tatcaaattg tccatcagca 1930501 tcccgcaaac gagcttataa tccaggatgc gggattaggg tttcagagaa ccaaggatat 1930561 ggtcatcatt agcatgacaa gcaaagcaag aaccgaaagc caaaaggaaa aattgtatgc 1930621 tctgcttgct gaaaggctag aaaaaaaatg cgaaatttcc cctgacgacc tcatggtatc 1930681 tattactgag aatggtgacg cagactggag tttcggtctc ggtgaggcgc aatttttgaa 1930741 tggaaaacta taagatttcg tctccccaca aaaaaaagaa gagagagctc caaagaagct 1930801 ctctcttttt tcataaatgc ggaagtcatc agtatagaag catccagcaa tacgaaaaac 1930861 ctggatctcc ttttatatcc ggtttaaatg ccaattggaa gctgactggg ttttggctga 1930921 aaatataaaa ttttgctgat ttgcataata agatacatca taatccccat ttacaatagg 1930981 ttggatgtta tagcttattg atcatttcct attttatata tccccttcat atgcacatga 1931041 catttttgcc aatccggaaa tatcagtctg acaaatataa aaagtcatgt aaacgggtgt 1931101 gaaccgtact tacatgactc accatggaaa caaaggctct ttttcaggtg ccgctttcct 1931161 tatttctctt cttcacacac tgtgtcacca ggctcgcaaa attgatcggc ccatgcctgc 1931221 atttcttgaa atacagcttg aagcgctgtt cctttttcag tcagcgtgta gatgactttg 1931281 accggcgttt cagggagaac ctgccgttcg acaatctcgt tttgttcaag ctccttcaag 1931341 cgctctgcca acattttttg gctgatcatc ggtattgttt ccgttatctc tttaaaccgt 1931401 ttcggcccat ccattagcac atggatgatc agaccgttcc atcgttttcc cagcaatgag 1931461 aatgcggatt ccattttagg gcacatcgta tttcccataa gtcttcatcc cttcatctat 1931521 tgattgacat gtattcaatg atccattaca ataatctttc aagttacatt tagtaagctt 1931581 ctaacttttc tattatcata ccacgtttat ccgaaggagg aaacactatg acgaatactc 1931641 tggatgtttt aaaagcacgt gcatctgtaa aggaatatga tacaaatgcc ccgatctcta 1931701 aggaggagct gactgagcta ttagaccttg ccactaaagc gccttctgct tggaaccttc 1931761 agcattggca ttttacagta ttccacagcg atgaatcaaa agcggagctt cttcctgtag 1931821 cgtataatca aaaacaaatc gttgagtctt ctgctgttgt tgccatttta ggcgatttaa 1931881 aggcaaatga aaacggtgaa gaagtttatg ctgaattagc aagccaaggc tatattacgg 1931941 atgaaatcaa acaaacattg ctcggccaaa tcaacggtgc ttaccaaagc gagcaattcg 1932001 cacgtgattc cgctttctta aatgcttctt tagctgctat gcagcttatg attgccgcaa 1932061 aagcaaaagg ttatgacact tgcgcaatcg gcggatttaa caaagagcag ttccaaaagc 1932121 aatttgatat cagtgagcgc tatgttccgg ttatgcttat ttcaatcggc aaagcagtga 1932181 agcctgcgca tcaaagcaac cgtctgccgc tttcaaaagt atcaacttgg ctgtaaggat 1932241 atgaaaaacc ttagtccgaa atccggacta aggttttttt atacaatcgc ctctttgtac 1932301 cattcacgag cctgttcagc ttcatgctga gtcagctgat ggcccccgtc ctgccagtaa 1932361 acggaggctg atgccccgct gtcacgcaaa tagcggtaaa gctcttctga ttcttccttc 1932421 gtgcaaagag gatcgtattt cccggcaccg ataaaaacag ggagccccgc catatcaggc 1932481 agctcgatac cccgaatcgg aaccattgga tgatgcagaa tagccccttt taacacatct 1932541 ttataatgaa aaagcaggct tgccgcaatg tttgcgccgt ttgaataacc gactgcaatc 1932601 actcggccgc gattaaactg atgcgtttct gcagcctcgt cgataaaatc tttcaattct 1932661 cttgtccgca ccacaagatc cttttcatca aaaactcctt cactcagacg tttgaaaaat 1932721 cgcggcattc cattttcaag caccgatcct ctgacaccaa gcaaatgggc atcagggtct 1932781 ataaaccgcc ccaatgaaag cagatcgtgt tcattaccac ccgtgccatg caacagcaaa 1932841 agtacgttgt cagatgttcc tttctcataa atatgcttca ttataaattc ccccttttaa 1932901 agttcaggta aaatgtctgt aatttgttgt ctatgtttct ccagccattc aggcagtttt 1932961 aaggaagtcc ctagctcagc aaacgtttca tctgtcataa agcccggttc atctgtggca 1933021 atttcaaata agataccgcc tttctcccta aaataaactg atgtaaagta ttccctgtcg 1933081 agaatttctg acgaaggcag atggttttca gcaataatcg gcagccattt cgcctgttcc 1933141 tttttcttag tccgaaacgc tacatggtgt accgtaccat atcctccgac tcctcttttt 1933201 tcaggatgta aatggacatc aatgacaccg ccgaccgccg ctgaagatgc cagtctgaca 1933261 atctggtctt cttcggccac tttggtgtat ccaaagcttt ccgttaacaa ttgtatggtc 1933321 gcctgcgggt cgtaggaata tagcagcaca cctttcattc ccgtaattgc ttcatttgtt 1933381 gtgatcccgt caggcgtcca ctcgcttttg ccgcttttcg catcctccat gatcgccagc 1933441 ggaaggtctt ctgtatcatc aaaaataaga cctttttcac caaacaacgt tttttcctct 1933501 aggctcagcc cgcttttctc aagacgttcc ttccaaaaag acagggagcc tgagggaact 1933561 gaaaagtaca cccggcccgc ttggcctttt cctaccgttc cctgtccgct tccttggaac 1933621 ggaaaaaagg tcattattgt accgggatct ccgttttgat tcccaaagta aaaatgatac 1933681 gttccgggat catcaaagtt tactgttttt ttaacgagcc tgagcccaag cacttctgta 1933741 taaaatcgca agttttcttg cggatctctg gcgaatgctg tgacatggtg caatccttct 1933801 gttttcattt tctcactcct atttatctcg atttcaagat atttattatt ttaaaccttt 1933861 attgaaaagg atgcaaacca tgtgttttga ttaaataatt gaaaaaatca tttttttcta 1933921 ataattatct tgtgatcttt tcttacaact gctattatag tgagcattat catgtttcag 1933981 gaggaaagta aatggttaaa aaagcactta ttgttattct cattcttttg ccattcgttc 1934041 agctcgcgct tttgccgctt gtgaatcgaa tagaaccgat tatgttcggc ctgccgtttt 1934101 tccacttttg gctgctgctg tggattattg ttacgccgtt atgctcgttt ggcatttatc 1934161 agatgcaaaa aaaagatgga ggacttgaat aatgcaaggg aatctgactg cacttctcat 1934221 tactgctatt attgttttaa ccgttgtctg tatcggcttt ctcgccggaa gagacaaatc 1934281 ctcacgtact tctgtggaag aatggtctgt cggcggcaga cgcttcggcg gtcttctcgt 1934341 ctggttttta gtaggcgctg acctttatac ggcctatact ttcttagggt tgaccagtac 1934401 tgcttttaca ggcggaagtg ttgcattttt cgccattcct tattctgtgt tggcctactt 1934461 tatcgcctac ttcttcttgc caaaactttg gaaagttgcg aaaattcata aattaacaac 1934521 actcgcggat tatgcccggg aacgttttaa cagtaagctt ttggcaagcc tcgttgccat 1934581 cgttggggta ctcatgctta ttccgtacat atgccttcag ctgagcggca ttcaagacac 1934641 gcttcaggtt gccggcactg gctatattaa cgtaaaattc gttgtgatca tttcatttat 1934701 tcttgttgct ctttacacat tcttcagcgg gattaaaggg cccacatata cagccatcat 1934761 taaggacatt ttagtatggg tcattatgct gtttatggtg gtgtccctcc ctctcattca 1934821 ttttaacggc tggacgccaa tgattgacac gttagtgaag gaagcgccgc aaatgctgac 1934881 gataccgtca gaagggccaa aaggcattcc ttggtttatc acagcatcta ttgtttccgc 1934941 tctggcactt tttatgtggg cacatgccgc tacaggtgtt ttcacggcga aaagcgctga 1935001 tgcagtaaga aaaaacagca tgtttttgcc gctttataat atcgtgttaa ttttggttat 1935061 ttttcttggc tttatcgcct ttcttgttct gccggaagat acaaatccaa ggctggcgct 1935121 gctgcatttg attcaaacat cttacggcgg cgtggcacaa ggctttgcat atgccactat 1935181 cgctcttgct tcattaatac cttgttccat tatggcaatc ggcgcatcga atttattcgc 1935241 caacaaccta taccgggatt tgattcatcc gaatgtgtcg caaagcaagc tgactcttgt 1935301 cacacgttca atggtgtttg ttgtcatcgg tcttgcgctg ctgtttggaa tgctgttccc 1935361 gactgcctta gtgacacttc agctattagg tgtatccggt atggtgcaaa tcttccctgc 1935421 gattgctgtc agcctgttct ggaaaaacca aacgaaagaa gcaacggtta tcggattatt 1935481 agccggccta gcggtaacgt ttattgtgta tatcactcaa tccgcacatg gcatttatga 1935541 aggattctgg ggattggccg ccaacatgat cgctgtggtc atcctgaatc cgctgttcgt 1935601 taaaaacgcg ggatccaatc ctgtcattga aggtttattt ggcaaaaaac aagacgctaa 1935661 tccaaatcaa aagggcgcat aaaaaaacca tacgcggcag ccgcgtatgg ttttttttac 1935721 atttcttttt tcagtgtttc aattgccttt tccatttgcg tatcattatc agacagcttc 1935781 ttttgaagtt ctatcattaa tttcgttgtt gtatcgccag tcagtatgcc tgtttcattc 1935841 agcttctctt ttttctggaa ctgtttgacg acagatacaa aatcctggtc atacatactg 1935901 ttaaccttta ccttgtaacc aagtgctttg agcattttct gagccacttt gacgtttgtg 1935961 cctgtatcac ctgatttgta cgttttatct gcgtccaaat acggcagctt cgcgtaatca 1936021 ggcagctctg ctttcacttg aggcttgatg ccttttttgt gaatccattc gccatcagca 1936081 gtcagccatt tggcaactgt cagtttgacg gtagagccat catcatattc ttttgccgtt 1936141 tgtactgtac ctttgccgaa tgtcgtctcg ccgattaacg gtacgtttga cgattcatga 1936201 agggcagcgg ccataatttc ggctgcgctt gctgtaccgt catttactaa aacgacggtc 1936261 ggcttggtca ctttccgttc tttttcggcc ttcatgactt cttttgaacc gtttttgtat 1936321 tcaacctgca tgatgttttt ccctttatca atgaacaggt tgctcatcgt aatcgcctgt 1936381 tccattaagc cgcccgggtt gcctctcaag tctaaaatat agcctttggc gccttttttc 1936441 tctaaactgt caatcgcatc tgtcagctct ttagctgttg tttcagagaa agaagtgatt 1936501 tgaatttctc cgatgttgtt gtctttcatc tctgaataga cagtctctac aggaatggta 1936561 tcgcgcttaa tggaaagatc gatattcccc actcccgctc tgttcagttc aagcttcacc 1936621 tttgtgccct ttttgcctcg gattaaagcg acggcttcat ttacattcat gccttttacg 1936681 ctttttccat ttaccttaat gatttggtcc ctcggtttga taccggcttt ttcagcaggt 1936741 gaacctttaa ttggggatac aataaggatt tctccgtctt tctcctctac ttgggctccg 1936801 attccttcaa aagatgctga aatcgtctcg tcgaatgatt tcgcttgctc ttgatccata 1936861 tatgtagaat acggatcatc cagtgattga atcattcctt taattgctcc gtctactaat 1936921 ttgtcatcat ctgttttttg gtaataatca cttttgattt gctcatacgc tttatttaat 1936981 ttgtcgaact tgctgtctcc tgtgcttgct gatttttggc ccaggatact ggaattgccc 1937041 gtaataaata aagtaagcgc cgaagcgaca actgcagtga tcagcacaat aaaaaacagt 1937101 tttaattgcc gtttcaatta aacaccacct ttttcttctt acattattat catggacgaa 1937161 ttcttattcg tcaactcgga gcagaaatga aagagaaacg cccttctttt gcttttcata 1937221 aacctatgtc tttatacgac atatgataag gaaaaaggag gattcgatat tgagccgata 1937281 tttagaaatg ctgtccttat tcggtgtcgc aggggcgcac ccaggcgggc tggctttttc 1937341 aaaagcggtc ttgcaaaagg ctgcaccctc tccggatcag ccgattcttg atgccggatg 1937401 cggaacaggg caaacggcgg cttatttagg acatttgctg tatcctgtaa cagtcgttga 1937461 taaagatcct attatgcttg agaaagcgaa aaaaagattt gcgaatgaag ggcttgccat 1937521 ccctgcatat caggcggagc tggaacatct cccgttttct tctgagtcct tttcctgcgt 1937581 cctgtcagaa tcggtcctca gtttttcacg cctgacatcc tctcttcaag aaatttcaag 1937641 agttttaaaa cccagcggga tgctgattgg tatcgaagct gctttaaaaa aaccaatgcc 1937701 ccctgcagaa aagaagcaaa tgatggattt ttacggattt acttgcttac atgaagaaag 1937761 cgaatggcat aaactcctaa gatcctatgg ctttcaaaaa acagaagcga tgtcacttct 1937821 tccggaagac atggaatttg aaccaaccac agaaatggat ttatcgcaaa cgattgatcc 1937881 catctattac gatacgcttc aaacacatta tcagctcatg cagttatata gtgagtacat 1937941 gggtcattgt atttttatcg cgtacaagta aaacggcgta tcgccccctg ttttcgtcca 1938001 accttttttt cctatctatc atatgctgat agaaagtcag gataggaggg gaacaatatt 1938061 ggagagatat tatcatcttt gcaaaaacca tcaaggtaaa gtcgtcagaa ttacagagag 1938121 aggcgggaga gttcacgtcg gcagaattac ccgtgtaaca agagacagag tttttatagc 1938181 tccggtcggc ggagggccaa gaggtttcgg ttacggatat tggggcggtt attggggata 1938241 tggagcggct tacgggattt ccctcggttt aattgcagga gtggctctgg ctggtttatt 1938301 cttctggtaa gcatagaaca aatgctagat tcaccagaca caatgaagcc cgcttatcta 1938361 gtgtaagcgg gcttttcatt ttaaattttc ttcacttttt caaagtactc ttcaagcgtt 1938421 aaatcattat cttggatgac ctttgcggct tttttgccta catagcgcag atgccatggc 1938481 tcatattcat atttcgtgat atcttcttta tttttcggat agcgaataat aaagccatat 1938541 ttataagcat tgtcctgcac ccatttcccg tctgccgtgc ttccgaacgc ttcatttagc 1938601 tcaaagccat tgctccggct cgaaatgtcc atcgcaaggc ctgtttgatg ctcgctttca 1938661 cccgggtaag cgaccgcttc ctttgccttc ctttcccctt ttaggcttac ttcattgtca 1938721 aaaatgactt tctgtctgtc atacgaacgg taccctgaga cagctgccag ttcatagcct 1938781 tcctttttgg cagcatcgaa cattgttttt aatgcgtcgg ccgcttcttt tctgatgtaa 1938841 cgtttttgaa tcttttcttc aaaagaaaac tctacatcag gtatgacaag atcgctaggt 1938901 tcatagtttc cgggcagtgc atattgttta ttgacaagcg cgagtatatt ttctggattt 1938961 tgaatggttt ccagaccatc gactttttta atatcattga aatactggct ttccaatgaa 1939021 aactcactgt tttgagtgtt tgattttttg ctgtcagctg ttttttgttc tgtttgcttt 1939081 gtttctgctg tggttttcgt atccttttga gcatctccgt tcgacatgct gcagccggct 1939141 ccgactattg ccgttacact cagagcggca gccagtgaga accatttacc ggactttttc 1939201 atattacatt accttccttt tatcaatcgt ttccgcatgc ataaagaaga ggctgccggc 1939261 acccagcacg cctcttgata tattttattg tgatacggaa tgtaaagcca cttctatcat 1939321 atcatgaaat gtcgtttgac gctcttccgc tgtcgtttct tctcctgtta atacgtgatc 1939381 actcacggtg agaattgaca gggcttttct tccgtgcttc gctgctaatg tatacaatgc 1939441 agttgtttcc atttcaacgc caagcacacc gtattttgca agtttttcaa tttgcgaatc 1939501 gtcattgtag aactggtcag ctgtaaatac gcttcctaca gtcaccggca cacctttatc 1939561 ctttgcggca tcataggcat tttttaaaag ctcgaaatct gcgcaaggcg caaaatcaac 1939621 gcttccgaaa gcaactctgt tcatttgtga atcagttgag gaggtcatcg ccaaaatgac 1939681 gtctcgcact ttgacatctt tacgaatagc gccgcaggaa ccgactctta ttagattttg 1939741 cacatcgtag ctttgaatta attcattcac ataaattgaa atagacggaa ctcccattcc 1939801 cgtgccttgt actgagattt ttttaccttt atatgtaccc gtaaatccat acatgcctct 1939861 gacttcattg tagcattcta cattttcaag atacgtttct gcaataaatt ttgctctgag 1939921 aggatctccc ggcaaaagca cagtatccgc aatttgtcct ttttcagcac ctatatgtac 1939981 actcatctca tatcctcctg taaatctaaa ttatcatcca gcccgtccat tttacaacga 1940041 atgtcatgat gaaacaaact tcagcattga ttataaagga atatatcgaa aaaagaaatg 1940101 ttcgaggatc tgttaggcac ttcctcagaa aaacggataa tcggggtgtt aatttgaaaa 1940161 cctaaccgca ggaaggaggg gtgggacatg ggtaaaaaac atcgtaaccg gatcaccggc 1940221 caaaaaaaga acaatcatat acctgaaaaa gatatcattg cagctgaaga agcacacggg 1940281 aaagaatatt ccgctgccaa acgcaagcct taaaactgca gaaaactgcg ggtttccgca 1940341 gttttctttt cattatgtcg tttgtacaat cagacgattg attttcctcc agccggcggg 1940401 aagcagttga taatatgttt tcccttttct gccttcatca atcaggatca cgtcccctgt 1940461 ggccatgaat cttgcatcat aatcactcgg aacagtgtcg aatacattaa acaaagagaa 1940521 tgctcttttc agcacgtctt gatgatcgct cccgttcagt tcagttcgat agacggctct 1940581 gtagcccttt ttttcgccaa accggggtgt ctgaaatatt gtcacgtcat aggaacaaga 1940641 cttcttttta aacacggata acatcatcaa gatcccctcc cttttatttc tttaacatat 1940701 tggcgttttt gctgtgtttt cctctctcta tttttgtcga aaccgcttaa tcttttcgtc 1940761 aaaacctttt actaggaaaa acagaagcaa gccgaggcta aagcctccta acacgtctgt 1940821 cacaaaatga acccccagat acactctgct tatgccgact aaaacagcaa ttacaccggc 1940881 tatgatatat accatttttt tatgcttaga caaaaacggg agatgtttca ctaaaaagta 1940941 agcaataaca ggatagacac aagcagcatt catggaatgg ccgctcggaa aactgaagga 1941001 tgattcatga accagcggtg caaaatcagg cctcactctt tcgatccatt cttttaagac 1941061 tttgtttaac agccgatctg tgccgaatac taagagcatc aacaggccgt cccatgtttt 1941121 tctgtagaaa aacatgcctg ctccaatgat gacaattaga gggagcagaa aagaagaagc 1941181 accaagatgc gtgatccccg tcatgacttc attaagccat ggctgacgga tcaaaacagc 1941241 tgccttgctt attgcttcat ctgcagattg aacagcattt gtatgaatgg ccgcagctag 1941301 aattaaaaag aaaagaaaca aactaacggg cttgtacaat tttaaccacc tcaattttca 1941361 cagaagtcat agaacatgaa taataaaacc ggagctgacc gctccggttt taagcctcac 1941421 tcatcttcat ccagctcttc atctatcata catttttcta tcaaataatc aaaggtaata 1941481 tcagcgattt caaacagctc atcctcactc ggtatgtagc cccgtcttgc aagctctctg 1941541 taaaaaaatt cagcgatttc ttccgtatca atcacaagat ctatttcttt catctccgta 1941601 ccgcctcctt ttttatgttt tatgaaaaaa caggctgaat tatacccggt gttctaaaca 1941661 attctttcag tcatatattg aataaaaaac gagccatggg aggctgacgc tatgattgct 1941721 aaaatgatgg aagcactgga cggagaaaga tttgatatca taatggaaaa aacgctcaaa 1941781 ggaatgacgc gtgtgatgat ttggggctgt ctgccatatt ttttatatgt cttgatccgt 1941841 atgttcacaa attaactgaa atgctctttt aaactttcca aaacaaacat catcatgtct 1941901 ttatattctt catcctgaaa catttcgtac agaattttgt agtcattata aatatccaga 1941961 agctcatcaa caattgacac agcaaggatg tgaagggtat cttgatcttc atcaccgcct 1942021 tcaaactgaa gaagagcaga cgatgcgata tcttcgccga tctcatggcc agtttctccg 1942081 acataatgga caaacaacag ctgatgcaca aactggtcca tttcatattt tctaagcacc 1942141 agcgtgagat cctcttcctc cgtttcaagc cactctccat cctttaaacg ggtcagctca 1942201 taaatgatat cttcccagcc atcttctaaa tatctccaaa tttctgttct atggccgata 1942261 atgcgaaaga gttcttttcc ataatcttta acataaacaa cgtccccaat aaggaattca 1942321 tactcaatat caagcttctc catgtcgaca atgacaccct cataatcttt ataaagctga 1942381 atagatgatt caaagtataa aacttcgtta tgattgactt cataaagata gtgtttatca 1942441 atttggtgta cttttgtgat ggtgccgact gttccataca taatgacgac tacgatatcc 1942501 cctacttgga atttcggttt attttgcttc atggtgtctc cccctcgccg caacatttct 1942561 catacgctat cgtatgccgg gtgaagccaa ttcgcatggg catgaaaacc aaaggaaata 1942621 tccaattatg gtatgggtat ggacataaaa aaatccgcag tgatctgcgg atgaaacagc 1942681 tattatctgc cgtgcacttc agactcgtat tgatcccaag cttcatcaaa cgtcgccatc 1942741 gtgtgaaggt aatcagcatt cagctccaaa tatgaactga tttcatgata atcggttgat 1942801 gtttttggaa agctgtgatc ctcatacgcc tgattggcaa attcactgat gctgtccttc 1942861 ggcttagggt gtctgtattt caataaatag tgataaaagg atttcatggg tttcccctcc 1942921 tgatgtctgt cttttgttgt tctattatac agttcaagtg taaaattaca acaaaagaat 1942981 actgaaacat gactcaggag aagtcaaaat agttgcgttt caaaattctt tctgtctcca 1943041 tgagctgctg atatgtcagg ctttcaggca gtttttttgt ttgaattaaa agcagctgat 1943101 cctcaatctc tttaaccgtg ttttcctctt gataggtcat accgcaggaa gaacatacca 1943161 tggcaggggt gtctgtcagt tctatagccc tcgttccatc agggagctcc cagtacaccg 1943221 tgttcctgcc gggcaccgct tcgagctcgc cgcaccattc gcatgttttc atgaagaatc 1943281 ccctccgcat tcagtctctt tctgtttttt ctgctgcgcc aaaaatttct tttctttgag 1943341 ctgatctctt ttctcacgcc gatcttttaa tgtttcatgc tccggatttg cgatgtatgc 1943401 ctctctcctt ttgattctgt ctacattttc aggtgtaaac gaaacttctt tgtcagcaaa 1943461 aatggcactc agcccgatcg gctccttttt gtcagcggtt tcagggaaaa cggactcaaa 1943521 ataggcgtct gcctgattgg ggatataatt ctctggttcc ggatatgacg taatcacacc 1943581 ttcaaaattt cttaagatca ctttgtcagg actttgtgac aggacatagt ttggctgcag 1943641 ggcgatttta cctcctccgc ctggtgcgtc aacgacaaag gtaggaaccg catagcctga 1943701 ggtatgacct ctcagccctt caatgatctc caaacctttg gaaacaggag ctctgaaatg 1943761 ccctattcct tctgacagat cacattggta aatataataa ggacggactc tgatttttac 1943821 caagtcatgc atgagctttt tcataattgg aaccgaatca ttaatacctg ctaatacgac 1943881 agcctgattt ccgaccggca ctcccgcgtt caccagcttt tcacatgcct caacggattc 1943941 ttctgtcatt tcgatgcttg tgttaaaatg ggtgttcagc cagaccggat gatatttttt 1944001 caatatctcg cacagatgat cggtaatgcg ctgcggaaag acgacgggag ctcttgttcc 1944061 gattctgatg acttccagat gcggaatgct gcgcagctct tttaaaatat attctaaaat 1944121 ttggtcgttg atgagcagcc catcaccgcc tgaaattaaa caatcgcgga tttcgggtgt 1944181 ttcccggata taagcaattg cagcatcaag ctgttttttg gggacgccca ttccgatttg 1944241 tccggaaaag cgccttcttg tgcagtagcg gcagtacatg gaacattgat tcgtgacaag 1944301 aaacagcaca cggtcgggat agcggtgtgt cagaccgggt accggtgaat cttcatcctc 1944361 atgaagcggg tcttccagat cgtattttgt tttgtgcatt tcttcagaaa gcggcacaga 1944421 ctgcatgcgt accgggcatc tcggattgtc ggggtccatt aaagaagcat agtaaggtgt 1944481 aatatttaag gggatcgttt tggtagaaat tctgacgcct tcctcttcat cctcggtcag 1944541 attaatgact ttctttaaat catctaacgt tcttacagtg tgtgtcagct gccaaagcca 1944601 atcgttccat ttctcttccg gaacgtcctt ccataactcg atctccttcc aatgccgttt 1944661 cggtttatac catttgtttt tcaaacgaac tcctcctcgc gcatattttg acttacagtt 1944721 gcttgcacca aatattcatg ttttcaaggc cttcggctat aaagcaatta ttgatcagcc 1944781 ttccgccata ctgataacct gaatggtaca acacagcatt catcccaaaa gacgaagcac 1944841 gggcgagaga aaacacatga acgatatcct ctccagccat ttctttttct aacgcctcga 1944901 ttaaaaagct tgttaacgaa tggccgcgat attccggcag cacagcgcaa tcggttattt 1944961 ctgcatgccc aagctctgga ttgatttctg cgcttgctgc gctgatcagg cggtcatgat 1945021 caagcatgat ataatacacc gtatttgcat tcatcgtctt ttcaatataa gcggggtcaa 1945081 ataccggggt tgggtacgtg cggaatactt ttttatacag catcgatagc tggtacatgt 1945141 cgtttgtttc tgcttttctc atcgtaaaaa cgggtgtact gtcgttgcga agacggggcg 1945201 ctgtgcgata tatggcttcg atgatctcct gttcctctgt ataagaatct gtttgtctcc 1945261 ggctttctga aaggtaacgt accatgacac aagccgaatg gccgagataa tagcccttta 1945321 gatagccctc cggcgcaaat aattgtttgg caaggatcgg ctcatcatgc tgcttcgcat 1945381 agacaatgat tttttctgca ttctcttctt ttgccgctgc cacgatatcc ggcagggcct 1945441 tctcaatggc tccgtcataa cgaaccactc tgattcgttt attaaagccg tcatggtcca 1945501 aaactgctgt gacaccgcta ctctttattg acttgagcat ccgcatcctc cccatctgta 1945561 tgaaggccgc accaatccat gacaaaaagt gcaataattt tagcagattc tatcatggct 1945621 tcaacctcaa tgtattcatt ggcctgatga gccgtttttg tttcccccgg cccgaaaacg 1945681 atcactggtg tatctcctgc atggtacaaa agccctccat ccgttcccca cggggaagcc 1945741 tcaataatcg gctctgtctg tttcattttt tgataggctg attgcagcac agaaattaaa 1945801 gggtgatcat caggtaaatc attcggcagc cattgagcgc caaaccattc gacttgtacg 1945861 ggatggcgtt taaaccattc gtcatggtat tctaaatcct tcagccagtt ttccaattca 1945921 agttttacag cttctggttt ctcatgggga gcaattccgc atctcccttc tatgacgaca 1945981 cggtctgcaa ctgaagatgg ccaggcaccg cctgagatgg tgccgatatt caccggtacc 1946041 ggtattggga tattgtcata cagcggatct gaaattctcg cattgcggac tttctccagc 1946101 tcttgtatcg ctgtgataac gtgcatgctt ttttcaatcg cgcttacccc ttcatagcgt 1946161 gtgcccccat gtgcggataa tcccttcaca gtgatccgaa accacatcga accctgctgc 1946221 ttaataaata gtttcatatt cgtcggttca ggaatcagcg ccccgtcagc acgatagcct 1946281 ctcatgatgg cggaaagtgt accggcgccg ccgcactctt catctacaac actctgaaac 1946341 aatacatctc ccttcagttt gacatcgcag gcgtgcaggg cttctaaagc aaaaagaagg 1946401 gctgtattgc ctcccttcat atccgttgag ccgcggccgt atattttacc gttttcttcg 1946461 acagcttgat acggttcata cttccaatcc tttacgcttc cttcaggcac aacatcgata 1946521 tggccgttca aaatcaggga cctgcctccg ccggctcccg tttttttagc cacgatattc 1946581 gggctctcat gaaaatcgga tcggttagat ttaaagtagg gatgctgttt taattgcttt 1946641 atgcttggct cccatacatc aatgtccata tgaaattgcc gcagcttttc aagcacaaca 1946701 gcttgggcgt taaactctga ccccaatgtg cttttttccc caatcagcct tttgagaaga 1946761 cgaatggctt tggccgaatg ctgatcaagc cactcgatta cttttctttc aatgtcttgc 1946821 atcctcattc cccctcttaa gaaaaaggca tatctatttt gatttcagct tctgtcagcc 1946881 tcgtcacctc atcgattgtc gagccattca tcagctcttt taaaatgaag tgatggctat 1946941 cgacctcaag aaccgctttt tcggtaataa tcaaatctac acagcctgca gcagttaatg 1947001 gcagcgtaca tctttctgtt aatttaggcc ttcccttttg atctgtatga ctcatgacga 1947061 caaccacttt tttcgctttt tgggcaagct ccatcgcccc gcccatacca ggcacctttt 1947121 ttcccggaac aagccaattt gccaaatctc ctgattggct cacctgcagg gcgcctaaaa 1947181 tcgtaatgtc aattttgcct tttctgatca tcgcaaaaga catggttgta tcaaaataag 1947241 aagccccttt tacagcgcgg acaggatatc ccgcggcgtt gcataaatgc gcatcctctt 1947301 ctcccttttc gggactttct ccaatgccaa ggacaccgtt ttccgcttga aacatgacct 1947361 gcatgtcagg cttcaaaaag ttcggtacca aggaagggat accgataccg agattcacaa 1947421 tcatgccctg cttaatttca gtagcagcgc gttttgcaat ctgttctctt tctgctactc 1947481 ccaagcccat ttccacttca ctccctcgct tcgtacaacc ccctcaacaa aaacccccgg 1947541 tgtgacaatc atttcttcag aaatctcccc catcggaacg atacgctcag cttcggcaaa 1947601 ggttctcctg gcggccattg ccataagcgg gttcatattg cgcgcggttt tgtcatacgt 1947661 tagattgccg aattcatctg caatgtaagc attgatgaaa gcaaaatcag cagtcagcgc 1947721 ctcttcaatc aagtatcgtt ttcccgccac tgttacgatg tccttttttt cgcaaaccat 1947781 ttgattatca atgcccacgt cggttaaaat accgccaagc cccgctccgc cggcgcgaat 1947841 ccgttccgca agcgttccct gaggtgaaaa ttgaacctct aacgtcccct ctgtcatctg 1947901 ttttccggct actggattgg aaccgatatg cgaggcgatc agggttttga cccgttgatt 1947961 aacaataagc gggccgattc cgatatccgg gaaaccggcg tcattgcaaa tcacagtcaa 1948021 atccgttaca ccgctgtcca atatcgcttc aatcaatgaa ggaggcgacc cgactccccc 1948081 aaaaccgcca aacatcagaa ccgatccatc ccgaacatct gcaattgctg tgtcaatgct 1948141 gattgctttt tgaaatggcg ccatttaatg tcaatccttt tttaagtttt tttcgaccgc 1948201 tgcaactgtt tctgaaaaaa tagagataag ctcttccatt tcaccgtctg aaatagtaaa 1948261 aggaggagca ataatgacag catctccttc tccactgtct attccagctt tggaaggata 1948321 aacaatcagc ccgcgttttt tcgcctcgct gacaataagc tgggttatcg cctgctctgg 1948381 cggaaacact ttcttcgttt tttggtctgc cacaaattca atgcctaata gcagtccttt 1948441 tccgcgcacc tcacctataa tgccgctttg agatgccgcc tcatcaagct tcttcttcag 1948501 cacagcgccc tttttttctg attgtttgat caagccgtgc tttaacacat atcgcaaaac 1948561 ttcaagagca gctttggctg aatagggatg tgcactatat gtgtgaccgc tcataatcac 1948621 acctgaccct tgttttatgg tttcaataat agaatcagat acgacggcag cagcaatagg 1948681 tgcatacccc gcaccgagtc ccttccccag tacagcaata tcaggtacgg tatcccaatg 1948741 ctctgtcgcg agcatccttc ctgttctccc aagccccgtc atcacttcat ctgcaataaa 1948801 aagcacatcg tgtgtgcggc atacctcact taatctctca taatatcccg gaggcggagt 1948861 aatcgctgct cctgcagcac caataatagg ctcagccaca aagccggcga tgaattggct 1948921 tccgattctt ttaatcatgg tgtccagttc atcagctgca gtctgaacaa agtcttcttc 1948981 cgtctcgtga ttcagccgat aaatatgtgg agctgagata gctggatacc gctcaatgag 1949041 atgggtgaac cggtatctcc tttcataaaa accagacaat gaaagcgctc ccaaagttat 1949101 tccgtggtaa ctgctccatc gagacaaaaa gatggatttt tgtgtttgct ttttttcctg 1949161 ccaatactga atggcgattt tcatagctgt ttctatcgct tctgatccgc tgttgacaaa 1949221 aaaagaccaa ttcacatctc cgggcagctc ctgtgccaag agagcggcta attgctcggc 1949281 gggctcactc gtaaactgtg agcggtaagc aaaagacacc tgatcaagct gttctttcag 1949341 cttctcagtc acatcacgaa ctccgtggcc gatattacat gtcaccgcac ctgacgagcc 1949401 gtcgagatat ttttttccgg tctgatcata aacatatgaa cccttcgcat aactgacaac 1949461 cggataggcc gagctaagct ctggcttaat caaataactg ctcatgctcc cacctcaaaa 1949521 ccccttttac catattgtat gagtgtccaa atggcggcat gacgttcccc gcaaaaactt 1949581 tttcacataa aaagagcctt cctaataagg aaggctcttt tgaaatttca gcatctagca 1949641 aataaaagcg gctccaacaa taattaataa aatgaacaag acaacaatta acacaaatgt 1949701 atttgtcccg cagccaaatc cgtaaccgta cccagagtat ccatacatgc tgttttcatc 1949761 ctttcttatc acgatatacg acattttatg cgggccaagt cccaaatggt ttgtgcaaac 1949821 gcctatttca tgtaaggaaa taatgaaata cagtatgcac ccgctcatat tttttaaacg 1949881 tcagcttttc gtaaaactga gttgcaccgt cagtgcttgc agccactaag taggctgctt 1949941 ccattcctag tgatttggcg atggacagca tttctttcac taagatactg ccgtagccct 1950001 tcctttgaaa ctgatctaaa attgccactt cttcgatttt agccgttttc tcttgatgat 1950061 cgataaacag ctcgccgcac ccaatgggaa ctttctgtgc ctggtcgctg taacaaacaa 1950121 caagaatgat tatatctgct tcatagaaag gatattttct ttttaatttt tgttcagcga 1950181 ttgcttctcc aatataaatg gaatcgtaaa ttttcataat agaagatccg tcgctaagac 1950241 tttttgccgt cccccatgcg gttaaaggat gtcccatctg ccccttccag tcactaagct 1950301 tcatgtcata tagtagctca tcctcgacga caaaaccgct ttttacaagt gactgcttca 1950361 aaccgagcgg aaaaacatgc tgcggcgacg cttttaaatg gagataattc gcatcaagca 1950421 gctttggtac ggagggtaaa aagttaagta accgctccaa tggaaacgta tcatggagct 1950481 gaacaaagtt atgagaaaaa atttgcggaa gctgcggatc tctgtatacg ctgtaatgat 1950541 caaacgatgc cgattcagac gttaacaata tatattgatg ttccgttttt gaataatgtc 1950601 ctgtcatgaa cgtctccttt ttatgaccta tacctttact ctgttgcaat attcaatttc 1950661 tttataatct catcgtacac cggataaaac ggctttccaa ttggaaattg ctgaatattt 1950721 cggaaagaag cggagattgg cttctgatgt aaaaaaaact tccttgttac ttgttcacta 1950781 atcgggtgaa agacgccgtt tagaaacaaa aacggctcgc gttcgatgaa aaacagacgt 1950841 cggccaggcg gatttttgat caattcagat cgtttccacg taatcggcgg cccttccgga 1950901 agcgtctcca tctcttcttt tccaattgtc actatgtctt ttctttgaaa ttgataaaat 1950961 tgaaacgcat actggtccac aattcgcctt ttttttccgg cttcgatata aaatattgca 1951021 ggatggtcag cttcctttac taaaatataa ttcggaatgt ttaaaatttt gccaatccta 1951081 tattggaata aatatgggtc tggaacagcg acagtccgat ttagatacaa aaaaccccac 1951141 ttttctccaa caggatgcct tacaccctga tcaaaaaaat acacattttg atctgaacct 1951201 tttacaaaag agccgtcaat caaatcggcg ggcagaaacc gatatgcatt ttgaaatgaa 1951261 tctggggttt tataggttgt gtctaatact tcatttatcg gcagaaatgg ggtaaagttg 1951321 ttgagtctcg cccaaaaaat tgcgtcgcca tgattccaat gcttcatatc atcatcccag 1951381 tagcctccaa atttatggtg aatgagatta agtaacgaac ggcgatgcat aactgagcaa 1951441 tgatcaactt gaaaagcggc ctgatcaagc actgcattgg catttctgta gaaatgtgag 1951501 atttcctctc ccctttcgtt tacatgtaca actttttgtt ttgaatagac cgcctgcgct 1951561 tcaggcttat gtgaaaactc ttgcaccata cggctcagcc gctcaggatg ataaacagtg 1951621 tcgtcagtaa gataggaaat gtaatcgccg tctgcaaatg ggagcgcact gttaattaat 1951681 gtggcataac gggctgtttt taatcgatct gcaggatgca cgaaactgtt atgatattga 1951741 atgcgccggt catggagata cttgtgaatc accgcagttg tttctgcatt cgaatgatca 1951801 tccatgataa aaagctccca aagatcatgc gtttgctgta tcacgctttc gatcgctttt 1951861 tgcaaataat cgggtttgtt gtaacttgtt aaaataatag acactttctc tcccatctat 1951921 accgcctccc gccgtcaaac ataaaaacgg ctccgcagca agcagagcct ctgtcatcat 1951981 ttaaaaagca ccccagctta caacacttga gagtgaaaca tgagatctcg tgttatttaa 1952041 cgggttttgg aaaataacca aatcagtcag aacttctttt acgatgacat tttgaagtgt 1952101 atctccgttg atcaaattga cttttgaaac cggtacgccc agctcttttg caaaaacaag 1952161 ctggcgtctg aggtcagatg gatttccttc agaagacgat tgacgtatca gcagaatcag 1952221 caaaagcaaa ataaaatgca gatcatcttg gttttcttct cgatccactt gtttctctaa 1952281 atccaaatca tccctctccc ttatccttat ctctgtttca caatatgtgc gacttcgatt 1952341 tatggtatag gctatgtcca ctccattaaa aaatcagcat tttccttaaa tagatgaaaa 1952401 atagatcagg tacggcgttc gactcatacc aaataacagc cggaagaata tgaataacgt 1952461 gagttcacta tcgaatagga ggtgtgtgta atgagctctg aaaatgcaca gttaaaaaag 1952521 gatttaatta aagccgtttt aagcccttta tttccaactg caacagaagg aggagaaaat 1952581 atggatagta atcttaaagc cttgcttgat gctgccatcg atcaaaaagt agatgaaagt 1952641 gaaacggtta cggcagaatc tattttagac ccttctcttc cggcaagatg gatttttgcc 1952701 agaattacgc caggcactac aatcagcatt gtgactgatt caggtgacat gatcggaccg 1952761 gttgttttcg ttgctttcga tcaggttcac gggatcgtat ttgtaacaca ggaaagctcc 1952821 gtcactccgg caggccaagc tacaacatta attgatgtag acaaagtaga aagcgttacg 1952881 ttcttttcat aacatccgat gaaagtcttg tatatccagt cgggatacgg aggaatatac 1952941 agttattttg atcgctgggc tgaagaatgt tttcagaaca ctcatacaga gtatatgatt 1953001 gcagataaac ctgaagcaga atctttgatg aagatcgaag cgtttcagcc ggatttcaca 1953061 cttatgatgg ttggagaccg cgttcctcac gactggctga cctggttaaa gggtaaggat 1953121 atccccgtgt atgtttggct gaccgaagac ccattttata tggatatcag ccttcaggta 1953181 attaagcttg ctgacgccat attaacgata gaacaaaatg cagctctcta ctatcaagag 1953241 ctcggctacc agaacgtcta ttatgttccg ataccagtta accatcggct gtttaaaaaa 1953301 atgggcaccg aacattccta tcattcaaat ctgttaatca tcggctatcc ttaccctaat 1953361 cgggttcagc ttatgaaaga agcggtccat ctgccattca cggttcgggt aatcggcaag 1953421 gaatggggaa aatatctgcc taaaaaagtg ctcaaacagc cgcatattga tgtcgtcagc 1953481 acatgggttc cacccgaaca ggccgttcat tattataatg gggcagacat cgtaattaat 1953541 gcgcatcgtc cctatcattt tgctttcaac caaaatacta tgcgcatcaa aaatgccagt 1953601 tttaataacc gaacgtttga tatcgctgca tgcgaagcat ttcaattaac agatttaccc 1953661 gcggcgcatc ctttttcatc cattatttct tatcacggca tgaacgactt taaggaaaaa 1953721 gccgctttct atatcaacca ccctgaagaa cggcaaaaag ctgcagcagc caattataaa 1953781 gagaccgtac ccgcatttac gtttgatgag cttcctgcaa aactaaaagc gattcatctg 1953841 gcgctttctt gaaaaatcgt tcattgctat gaacgatttt tttattcata gaaaaaagca 1953901 gctgcacaag ctgctttcta ttctagccgt cagaacggtc tttcagcttc ctcggattta 1953961 cctgtttatg aagatcaggc atttcgccga gatgctgtgc aatttgttcc cacgatacaa 1954021 ttttgaaatt ttgattgacg gcttgtccgt tatcaatatt ttcgccgtcc tgcgccacaa 1954081 aaatcccgta cggatatttt gggccaagtc cgaaaccgag aacatcaata ccatccgtgt 1954141 cactagtacc gtctatcttc tcgccatctg taatctcaaa gttggctaca tagcgatttt 1954201 tcccctgccg ttcatacatt gcatagctgt tatttccttg acttgaagcc atgagatatc 1954261 ctttgccatt tggtgcataa tagattgtca gtccttcaat atcagctgtc aaatgatctc 1954321 ctgtcgcacg gtcaacaacc tgcccctttg accctccgcc gggctcagcg ttaaatttcc 1954381 agatggcctc atcttcctct gctatgtata ggtttccgta ctcatcatcc gcaacaaggc 1954441 cttcggtctg agaattcaac ttaaattcac gcaccttttt ccctgttaca taaccctttc 1954501 caccatcaac aatttcatac tgctcaaatt ccccttgttt gcctgtcact aatgcgtaaa 1954561 atgctcctgt tttctggctg tgatacaagc tgaatccata aacctcagaa atattggtgg 1954621 aaataggatg gttcggatct gtaatgcttt tcaattttcc tttatccccg tctattgcat 1954681 atacttcaat tgtatttttt ccttcggacc ggttggatgc ggcagcaata tcaatttttt 1954741 cgccgttcaa tggaaaatca tagcgcagat cgacattatt gagcttgcca aactcataag 1954801 aatgaagctg ttttccgtct aaatcataca caacgagccc tgacttctta tttgttgtaa 1954861 tcaacttgct tttttccggg tgtttttcat gaacccaaat ggccgggtca tctgctgcat 1954921 catcgccaga tgcgaccgga tctgtctccg tgtgtgcagt cactttgaaa tgatgttcct 1954981 cattcacata atgagccgac accgaggttg ctgtcaggct aagcaataaa cccgcggcag 1955041 tgcttagcag cattgttttt ggaaccttca tttggtaccc tcctctttta tcactaacac 1955101 tactattgta aaatatatac aggtgattac cgtgaggaaa atgaaccttt ttttataggg 1955161 tttctgactc ataaacaact tattccccaa agaggtggtg agatgacttt gccagattta 1955221 cttttgcgga gcgaaataaa aatatgttga atatttagta cattatttat ttagttttgt 1955281 ttttccctag ttacgtccgt ttttccattt tctattaaaa aagaacactt tgtgacatga 1955341 tcattcccct aaattttgtt ttattggttg ctttcattaa ttcgattaca aagttgaaca 1955401 tatgatgcat ggtagagaaa cgagagttgg aggataagcc atgcctaaac agcaaacagc 1955461 agaactaaaa ccatttttcc ataacaaaac agttttagtc actggcggaa cgggttcaat 1955521 cgggagtcaa attgtcaaac gccttttgat gcttacacct aaacaggtga ttgtattcag 1955581 caaagacgac agtaaacagt atgtcatgag ccaaaagtat gcggaggata agcggctatt 1955641 atttgtactt ggagatgtac gcgatcacag aagggtgaat caggtgatga aaggcgtcga 1955701 tatcgtcttt cacgcggctg cgctgaaaca ggttccgaca tgtgaggacc atccatttga 1955761 agcgatccag accaatctca tcggcggaca aaatgtggtg gaagctgccc tttcacaccg 1955821 agtgcagcat gtcattaata tcagtacaga taaagctgta tctcctgtga acacaatggg 1955881 tgccaccaag ctgttatctg aaaagctgtt tcatcaagca aaccgccacg tccaaaacaa 1955941 aggaaccttg ttttgttcgg tccgctttgg aaatgttctc ggttccagag gttcggtcat 1956001 ccccatatta tttgaacaga tgatggaggg tgaacctctg accatcacag acaaaaacat 1956061 gaccagattt ttcatgtcaa tagacgatgc agctacattg acattacaat cggctgctat 1956121 tacaaaaggc ggagaaacct ttattttcaa aatggaatca ctgaaacttg aagaactgat 1956181 tcatgggttt gaagaatatg catcgcagca cgggctcccg cggccggctg cagtagaagt 1956241 gggcaagcgt ccaggtgaaa agcttcacga agaattaaca tctccacatg aaattgaatc 1956301 actgtatgaa tggggcaacc tttatgcgat ccttccagag ccggaaaaac atcctgactt 1956361 tcgcaaagtc aatctgcctg ggtatcaatc agatcaagcc ccgctcatta cgaaagaaag 1956421 aattgctcag attattgaag aattgcatca agagaaaaag gcataaaaac aagcctgtct 1956481 atccattagg caggcctgtt tttaacagtt tatttattaa agagatgcag atagctttcg 1956541 tatccttctt cttttagctt atgcttcgga acaaaccgca gcgctgctga atttatgcag 1956601 taacgaagtc cgtttggccc cggtccgtca ttaaatacgt ggccaagatg agaatcagca 1956661 gttcggcttc ttacttctgt gcgaatcatg ccgtggctcg tgtccagttt ttcttccact 1956721 tcttcttcaa tcggctttgt aaagcttggc cagccgcatt gggaatcaaa tttatctttg 1956781 gatgtaaaca atggcttgcc tgacacaatg tctacataca acccttcttc cttatgatcc 1956841 caatattcat tttgaaatgg cggctccgtg ccgttatttt gcgttacttc atattgcatg 1956901 cgatttaatg actttatttt ttcttcttta ttgtacgcca tttatttagc cccccaatgc 1956961 tcgctgataa atcccgctcg tccggaacct gtccggtagc gctgataatg tgctggattc 1957021 tttttataaa aatgctgatg gtagccttcc gcttcataga aaggttcagc ttttaaaatg 1957081 tccgttacaa tcggatcttt aaagatgccg ctttccgcca gacgttgctt ggaagcttcc 1957141 gcaagctcct tttgtttatc attatgataa aaaatggctg cgcgatagga actgccgcga 1957201 tcagcaaatt gccctccggc atctgtcgga tcgatttgct gccaaaataa ttcaagcagt 1957261 ttttcataag ggaatacatc aggatgaaac gtgatttgaa cggcttcacg atgtcccgtc 1957321 gtttcactgc acacctcttc gtacgtaggg ttttcagtat ggccgcctgt atacccggac 1957381 accacttttt caattcccgg ctgttcgtca aaaggtttaa ccatacacca aaaacagcct 1957441 cctgcaaatg tggcgatttc ttttttttca gacatactgg tgcctccttt gttaatacgt 1957501 ggtattatta tattatagca tgtaaaaata gaatgaaaat gattctgctt ttcaataaaa 1957561 tctataggtt ttaagcaata tgcttatgta atggaggttc acaaatttga aagtaagaac 1957621 acagatgatg tacgatatgg aaactttact ccgtaaagtc tttaaacaaa tacgcaatga 1957681 aatcaatgaa attttagata aagagctgtc gcggaatgaa ttcaccattc ttcgaatcct 1957741 tagtgaacaa gggcctaaaa aagtcactga atttgcgcct attttagagg tatcggcaag 1957801 ccacattacg gctgtgaccg atgcgctggt agaaaaggaa tggattacga gaatcagatc 1957861 gaaggaagac agacgcatca tccgcattca tatcactgaa gcgggcgaaa aagtccttca 1957921 gcactttaac gagaaaaaaa cggaatattt ctttaaacgc tttgactgct acactgatgc 1957981 tgaacttgcc acgttaatcg agctcttcag caaacttgat aaaaaacggt gaaaaaaagc 1958041 acataccgat atataggtat gtgcttttcg cagtgcttca cttatttttc agtaaacagc 1958101 ttcattgctt tccagcggcc atatctataa tacaaaaatg ccgcgcagct gctaaataaa 1958161 aaactcattc cgattccaag cccgattcct ttttgtccaa gccaagctga aaatagagct 1958221 gtgaaaggat acctcaacac ccaaaacgag atcaaattta ataccagaac ctgcagcatc 1958281 gctcccgcgg ccctgacgat tccgttcagc acaaaattaa ccccaataaa agggtagaaa 1958341 aacgcgatcc acttcaaata ttgttcacca aatgcgaccg catcaggctc actgataaat 1958401 aaccttatga ggtatttacc aaatacccaa atcataaccg caatcaccag catgcaggaa 1958461 ataacagcta tcacacctag ccttgcaatt gttcccactc ttttttcgtt tccgattcca 1958521 atattttgcc ctgccatact attgacggcc gtaccggcag ccattgctgg aagcgtgatg 1958581 atgctatcaa gccgctgcac cgcgccaaag cctgatacca cgtgatcccc gtatgagtta 1958641 acaacactca taatcgccat cataccgcct gtaatcacca tcatctgcag acctgccgga 1958701 atcccgagtt tcaaaatcag cgcggactct tcccacttgg gcattctcgg aatcgagaat 1958761 ggcacaagct tgtgtttgat gacataaaac aacccataca aaaacgcaat gccctgtgac 1958821 aaaatcgttg aataagccgc tcccgctatt cccatgcgga acacagaaat aaagagcggc 1958881 gcaagcactg tattcagtac aacagcaaac gcaataaacc ggagaggtgt cttgctgtcg 1958941 cccagcgcac gaagcacagt actgataaag ttataaccaa acaaaaataa aatgccgata 1959001 aattgaatct gtaaatacgt ctcagcaagc ggtatcattg actccggcgt ttttagaaga 1959061 cgcagcaaaa gctctgagag aaaaaaaccg gccgcgccga atccgatgct taggcctgtt 1959121 aataaaacaa caaaagcgtt aatatacgac gccattcctt ttatatcatc ttttcctttt 1959181 tgctgagata aaatggttaa cgtcgcattg ttaaggccca aaataaaaga cagcacggtc 1959241 aaaacaatcg tgcttgatac cgcggctgcc ccaagggcct ttgcccccag taaattgccg 1959301 atccacaagc tgtctataaa ttgaaaggaa acctgcaatg cgtttccgag cataataggc 1959361 attgaaaaca gtacaagctg tttcagcacg ttcccctgtg taaaatcgta tgctttcatc 1959421 ttttctcctt gtgttctcaa attttcttcg gaccacacga aaaaagagac gttgtttcat 1959481 gtctcttttt tcatgactta tcggtttttt ttcggtctcg cataccgaat gtaaacacca 1959541 tcacacttag gaacaaggca caataggaaa cattcaaata catttgatcc atatcttcag 1959601 cagccagatg atgataagca agccagccga agtacaggga aaatgtaaag gataataaac 1959661 tgaaatactg gtaaatccgt ttcattttca gtcacctcta ttgtttagga tggtaatagg 1959721 aaaactcaat ttcatctttt tctaaattta tcttatccgc tttgacatac attccattcg 1959781 ttaaaggcat ttctgacaaa cgcacttcaa tgcttttatc tccggggtga acatggacaa 1959841 atgacggcaa ttcataaaag ctgtccatat aatttaacac aaagctaatt ggtatactca 1959901 atttccctaa cgaaaatttc gtgacattca gctctacatc accgtttttt ttcacggtcg 1959961 gctcaaaagc gataaacgca tcaatagacg tggaaaatgc cttgattttc cctgcgacat 1960021 gaacatcatc atcaatctct actttataat caagcttgtt tgatgctttg tcgtttaaat 1960081 atgagttaac aaacgcagct aatgattctt ttgtgcttgt cacttgaaat ccatactcgc 1960141 tctcagatgc atctttcacc tgagcctgtt cccccggaag caaaacaagt gccacaaacc 1960201 cggcggcgag gataaaattg attgcaagca atataaaaaa cagtcgcttc cacttattca 1960261 tgctgtcacc ctactctttc ggtaatcctt cttttttaat ggcttgatag acgcgctttg 1960321 cgataagaga ataacccgta ccattaggat gaaaatcatc ttcctcagaa attcggctgc 1960381 tgtcactttt ttgattaaac aaatcttcga tatggacgat ttttgcatgt ttatcttttt 1960441 tcagctcttt ttcagcaata tggttccaat ccgtgacgac accatttatt tcatttagtt 1960501 ctgataatgt aaacgtaaac ggattgtaca tgctgacata aatcagctca gcgtgatcat 1960561 tcagctcgcg aatttcagaa atgatttttt caaagcgctt ttcgtacggt ttttccgctt 1960621 cctgaaacgg ttcaacggtt aattgcagaa agttttggcg aaggattttc atcaaatcat 1960681 taccgccaat tgtaaaaaag acataatctg cgtcctttat gcctttttga acctttttat 1960741 cttttagttt ttctaataaa tcatccgaac ggttcccttt tacagcataa tttttcacgt 1960801 cgaccgtttt gacttgttta tctgaccgga tagaatccgc caccttgccg acatatccct 1960861 ttccgtcggg atctccgact ccttctgtca gcgaatctcc gacagccgct atgacaatgt 1960921 gttcttttgt tttcgtttca tgggcttttt gttttccctc agatgatgta cgtatgctcg 1960981 tacacgcagt aagaagcaaa atcaaactgg ccatgattga aaaaatgcgc agcttcaatc 1961041 ttgttgctcc ttcccattct actagtggaa agtgtatcat gttttagaag atttgcaaat 1961101 gcctagtctc ttagcttact tgagtgtact ggctgacttc acatcggaaa tgatatcatc 1961161 gtacggtgta ttctccactc cattgtaatc tttcagcacc ttaccgtccg gacctaccaa 1961221 ataaaaagaa gattgatgaa tcacttggtc ctctccctcc ggcttcttta cgatcgcttt 1961281 aaagctctta agtgcgaact cctcaatctc actctggctg tatcccgtga gaaaatccca 1961341 gttatcaaaa gataatggat aatttgcggc aaatttcttc agctgtttcg gcttatcgtt 1961401 ttctggatca acactaaatg atatgatgcg gacatctata ttttcggctt tcagtttttt 1961461 ttgcagatcg gtcatatgag cggtcattgg cggacatata gtttcacaat tggtaaaaat 1961521 aaaatccgcc agccatactt ctccttttaa actctctaaa gaaacgttct tgccgtcttg 1961581 gttttgaaat gtaaaaggct ccacctcgta attgagcgga tctttaatct gctgtcctcc 1961641 gcatgcacac aaaaacagaa aaatcagccc agccgttaac cccttgataa ccttcatgac 1961701 atccatcctt tccagccagc ataaaaacgc tttctaaaac cgtccttact gtcccatgtt 1961761 tgtattcgat actgagcaaa aaaaatcctg catgcctccc cattaacgat tacaaaggag 1961821 ggcatgcagg taaaaaacgg catgttacgc gttgtgcttt aacacctctt gatgaaatac 1961881 agcctgataa tctgcccact tcatccgccg cttcatataa tgtcggaaag aatacacttt 1961941 tgccctgctg tttgatgaaa acacttcttt taagtagaat tgcaaatggt gatgtaacat 1962001 aaagaaatag tgctcatctt cctttaatac aggtatttct gtcactttca cctgaatccc 1962061 gtcaccgcgt ttgaactcta ggcttttgag taacaagcta tcaatcctct tttttgtttt 1962121 tcttctatta tatatgatgc cagccgggct gtctgtcatt ttgcgcggtt gtgtaaaaaa 1962181 attagattag caaatggaac aagtcctcat ccttgttcac ctctacataa tgaaacggtt 1962241 ttttgttcat ccgttcaatc agcggcccat aatcggcttt gttctgcagc tcgatgccga 1962301 caagagcagg tccattgctt ttattatttt tcttcgtata ttcaaacctt gtaatgtcat 1962361 cattcggccc gaggacttcg tcaagaaatt cgcggagcgc ccccgctctt tgtggaaaat 1962421 tgacgataaa ataatgctga aggccttcaa aaatcaagga acgctccttc atttcctgca 1962481 ttcttccgat atcgttattg cccccgctta ccacacacac cacgtttttc cctttaattt 1962541 gatccttgta caaatcaagc gctgcgacag aaagagctcc agccggttca gcaacaaccg 1962601 cacattcgtt atataattca agaatggatg tacatacttt tccttcaggc acaaggagaa 1962661 tgtcatcaac gacagtttcc agcgtccgga aggtttcctc gccaattttt ttaacagccg 1962721 ccccatctac aaacttatca attttatcaa gtgtgacgac atgcccagct ttgtttgatt 1962781 caaagtagga tgccgctccc gccggctcaa cagcaattac ctttgtatca ggagacacgt 1962841 ttttcaaata tgtacctacc ccagagagaa ggccgccgcc tccgacactt gcaaaaagaa 1962901 aatgcggttc tgtatcaatg tcgtttaaaa tctcgactgc gagcgttccc tgtccggcca 1962961 tcacatccgg atcatcgaac ggatggataa acgtccgaga ttccgcctca cagcattcag 1963021 cagcgctttt atacgcgtcg tcaaacgtat cgcctgtcaa aataatatcg ataaatcctt 1963081 ttccgaatag ttcaacttga gatacttttt gtctcggtgt agtagacggc ataaaaattt 1963141 tcccgtgaat gccaagatgt ttacacgaaa atgccacacc ttgagcgtgg tttccggcac 1963201 ttgcacacac aactccgttc tctgtctgct cgctggaaag ctgtttcatt ttatgataag 1963261 cccctctgag cttaaaagat ctgacaactt gcaagtcttc gcgttttaaa tagatattgc 1963321 attcatatct ctcagaaagt ctgtcattcc tctgcaaagg tgtgtgaatg acaacgtcct 1963381 ttacgttttg gtgagccttc aaaatgtctt tcacttggat gagagagttt tctttaagca 1963441 acggtttcat gtacagattc ctttcttgtt ttaaatccct atttaatatg ccattataac 1963501 atgaatattc aaaaaataag acaattattt ttatttaata attaaaaaaa tacagactat 1963561 gtccaccaca tcttgtggta acttctgttc aaccattatc ctgcagagcc aagaaaaaag 1963621 atgatcgtaa aataaagggt gttttcaacc aaaaggcatg atataatgaa accaattaga 1963681 accaaaagga gccaattgat gaatagtgca ccaaaactca atacatttca acatctaatc 1963741 ggagaacatc aaacttttct ggaagcgaag cgaatcgcca agcagttctc gttatcggag 1963801 cttcctgtct taataacagg aaaaatcgga acaggcaaaa atcacttcgc acatgccata 1963861 cacttggaat cttcgagaag caatgaaccg tttataagcg tcaattgcag cacccattcg 1963921 gaagaaaccc ttattcatga gctttttggc cctaacggaa acacaggtgt ttttcaaaaa 1963981 gcggtacgag gaaccctttt tcttgatgat gtatggcgca tgcctgcttc tgtacaagct 1964041 cagctgttaa aagcgcttga ttcagacacg gagaaaccgc gaatgatctg tgcttctgca 1964101 gaccgatccg tggaacatac attcaggcaa gacttattct acagactgaa cattttaacg 1964161 ctcacactgc ccgaattatc ggaacgaaaa agcgatattc cgcttttgac acagcatttt 1964221 ctctcaaatt ctggtcagca attgttaatc gatccctccg tttttcccgt gcttgagaag 1964281 catgcatttg aaggcaatgt cagggaatta aaaaacgctg cagattatat ggcggcagta 1964341 tcaagcgggg gaacgattca gccatatgac ctgccgccgt atattagagg cacgatagac 1964401 ggaaaaacgt cgaagaaaaa agcgaaactg cttactttaa tggaaaaagc tgagtttttg 1964461 tttattttgg aaacaataaa agtattgaac gaaaaaggag aacctgccag cagacggatc 1964521 atttctgaac acagcaaaaa tacccaaacc tcgttaactc ctcagcaggt cagaagccgt 1964581 ctcgactatt tggagaaaaa agattatgtc accaaaagcc gcggacgcgc aggcacaaaa 1964641 attacctttg agggcttgag ctttatagag acgttaaaaa atcaaatgat ctagcgatcg 1964701 aaaggagaat gtacttgttt acaatcaaag aagagatcgc caatgcgatt acacacggca 1964761 tcggtgtcct cttatccatc ccagcattag tgtttctaat catatttgcg gctaattacg 1964821 ggtctgcatg ggacattgtc agctttacaa tattcggtgt ctctatgctg ctgttatatt 1964881 tgagctccac cctgcttcac agcatcacac ataaaaaaac gaaggacatt ttggagatta 1964941 ttgatcatag cgcaatttac gtactcatcg ccggaaccta cacgcctttt ttgcttgggc 1965001 cgctgaaagg cacactcggc tttaccctgt tggttatcgt atggtcactt gccctaggcg 1965061 gaatcgtttt taaaattttc tttgtgaaac ggtttatcct attgtcaacc ttcgtgtatt 1965121 tagtcatggg gtggctgatg attattgcag ttaaaccttt atatgcttca ctgagcggag 1965181 cgggattcag cctccttttt ctcggcggca ttttatactc tgtcggaacc atcttttaca 1965241 tttggaaaaa gatccccttc catcacgcca tttggcacag ctttgtattg ggcgggagcg 1965301 ctgccatgtt tttctgcgtg ctcttctatt gtgtaaaggt gcctttcctt tcgtaacagt 1965361 aacagaaaag cgcagtcttc acgactgcgc ttttttatgc acgtaattgt ttttcattgg 1965421 caggtatata agcttttgaa aaggacaatt caatgtctgc cggttttaag cgtttaaaaa 1965481 acgagccatt ttgcatgtta tctgttcctt tcgtttccac catcaccaac ggaagatgat 1965541 agcgggccgc aagttctaca ggatcaatag aaccatctag tgaaagaatc aggctttgtc 1965601 ccttttccag ctgttttgtc acatcttcat ataccttttc tgaatccccg tctgaaatca 1965661 catccatccg atccagccat tgcccgataa aaggcaagcg gaacactttt gggttagcga 1965721 taaagccggc cggttcctca atatatccag caattaaggc cagttcagcc aaacgcaaac 1965781 ggggatgcac atacaaaaca ggaccgtgtg gtattggctc tggctgatgg atcgtcacaa 1965841 ctgaaccgga gatgccgata cagccttcta aaaacgcctt tggctgttcg tacacaagag 1965901 ccatctgttt tttgtatgac agacggggat cgagcattgt ttgattaaat aattgtttca 1965961 tattttttaa cagcatatac acaatataaa ccactagaag gctgtagcga accaattaaa 1966021 atcctcccgc tttagaagaa ttcttttttt catacattag aaattcgtaa tcatacgggt 1966081 ttttttcgtc tttggtcccc tgctcagaag aaaccagctt ccaattggat tcatcaaatt 1966141 caggaaagtg acggtcaccc tcaaactcgt gatgaatttt cgtcatatac agtctgtccg 1966201 cataagggaa caggtccgta tagagctgag cccctccgat cacaaagcat tcttcagggc 1966261 ctgaacaaat gtccagtaca tcctttaatg aactgacaac cgtgcatccc tgaaattctg 1966321 aatccggcgc tgaggtaacg acaatatttt tccgatttgg aagcggacgt ccgatcgatt 1966381 caaatgtttt ccggcccata atgattgaat ggcccgatgt tattttctta aagtatgcaa 1966441 gatcattggg caaatgccac ggcaaatcat tgtctttgcc gataagcctg ttggcatcca 1966501 tcgcaaaaat gaatgaaatc atacgctgac cgcccctttt atatgaggat gcggatcata 1966561 atcctcgatg ataaagtcct caaatgcaaa gttaaaaata gaatcaacct ttctggcgaa 1966621 acgaagctgc ggaagcggtc taacatctct ttccagctgc aaattgactt gttcaatatg 1966681 attttggtaa atatgaacat caccaaacgt atggatgaac tcgcccggtt caagcccagt 1966741 cacatgagca atgatcatgg ttaggagggc ataagatgca atattaaacg gcacacctaa 1966801 gaaaacatcg gcagagcgct gatacagctg acaggacagc ttgccgtcag acacatagaa 1966861 ttggaacagg caatggcacg gcggcaacgc cattttatca atttcaccaa cattccaggc 1966921 gctgacgatt aagcgtctgg agttcggatt tgttttaata tcttcaataa gacgggaaat 1966981 ttgatcaatg gtttctccat cagctccccg ccaagaacgc cattgggagc catatacagg 1967041 tccaagttca ccgttttcat cagcccactc attccagatt cgcactccgt tttcctgcag 1967101 atagcgtaca ttcgtatctc cttttaagaa ccacagcagt tcatgcgcaa ttgatttaaa 1967161 gtggagtttt ttagtggtga gcatcggaaa gccttcccgt aaattaaatc tcatttgata 1967221 tccgaaagtg ctgattgttc cggtcccagt ccggtctccc tttttctcac catgctctaa 1967281 aacatgtctg cagaaatcct tatactgttt catttttttc atcctttaaa agtagtcttc 1967341 tagtagtgta acacaataaa aaatcatttc tgaacccaga aatgattttt ttatagtcag 1967401 ctgacgacag gcttttcatc ctgttctttt tcttcatctt gcagatcctg atgcgtatgt 1967461 gcaattctgc tcgccgctgc tgcagcaaga gctgccacaa tatcatccaa aaaggtgtga 1967521 ataccgtctg gactttcatc aagttcctta ataattccaa tcttctcttt atccaaataa 1967581 ccgaaattgg tcaaaccgat cgacccgtac acattaacga ttgaaagcgg gataatttca 1967641 tctatgccgt aaagcggttc atccgtttca acaaggtgct gcagcggttc ggggagaagt 1967701 ttctgttctg caagctgatc gagtgcaagg cctgtcaaaa cagcatgaat aatttcacgt 1967761 ttgttcagga ctttttctac attctccatg caaacactga gcggcagatt tggattgtat 1967821 ttttcctgaa gtttttgaac aatccgtgca atatcttcta tcataacgcc ccgtttgttc 1967881 agcatatcct ttgttatatc gaccatttca ttcattgtgt actttttcat gtctaatggc 1967941 atctccttta ggcactcatc cagttgggag gcgtgttgcg gtcccagtaa atgctcccaa 1968001 gctcatgatg tgattgaaat ccatcttctg ctgtatgata atgaaaatta aaccagtagc 1968061 cgtcatgagg cgggtggtct cttcgcacat ggaatctgag aagatcttct ccagttgtcc 1968121 gattgtaaac gttgaaaatt ttttccgttt tgcccgctga aggcatgctt gagatcacaa 1968181 catcttggta cgcctcatca tcttgcaatg tcgctaaata atcactaatc acattttcga 1968241 tttttggcag gatctctttc cgatagtcat cctcaatgac aggagcgatt ctgctgccga 1968301 attttaaaaa ggactgatcc tcagcgctgt caaggagctg ttccttgtac gattgaaaaa 1968361 gcagttcagg atctcgcctg tcatccgact catcatcgta caggtcatgc tcatcataaa 1968421 aagcggtgta atcattctgc tcaagactgc tcggctgtcc ggaaggcttg tccgccataa 1968481 gggcagccgg aggagatacg agcccgaacg ttacaatggt aaataaaacc acaagggtct 1968541 ttctcatcca caatttcatg actgcttatt cctctctatt ttattgtcat gtttctctta 1968601 ttttagcaca tccaaaacat gcaagtcatg tactatatga aactgatatg caaattagga 1968661 gattcgttgc tatgcacttt gtgtaaaaac gcttacaata tttcatgaaa ggaggctttc 1968721 cgcatgattg acgctctgtt tgccacagtt tcactcttaa cattattata ctttgtcgtc 1968781 atggaggtca ccgattaaca gaaagcccgt gatatgaatc acgggcttgt ttgaatgacg 1968841 ccataatgga acagtgctgt ttttcttttc atgacgttaa aaccaaactg ttcaaaccgc 1968901 gggcttttcc agtggtcttt tagcacaacg ctttttctgg cgactcgtac cgcttcattg 1968961 atacatcctt cgtgcaaaac ggaatcctct gccaaatcac gtaaaggcgc gatgccgtca 1969021 gaggtttcta caggttcatg aaacattgga tcgaaataaa ccacatcaac agagttgtca 1969081 gggagctgct tgatgtgttc aaagcaatca ccattcttca cctggattct tctcatcgca 1969141 gcttgaagct cttctatacc cgtttcccat gaatgcagcc ccgtcctcac taaaacagac 1969201 acaagatggt ttttttcaat cccaacaaca gaacccgttt cgcctactgc catacttgcg 1969261 ataatggcat ctgaccccaa cccgagtgtg caatctaaaa acgtatcccc ttcagataag 1969321 ccggcagccc gaagcatagg ttctttctcc ccctgtaaga agcgtttggc tctgaacatc 1969381 gctgtattcg gatgaaaaaa gaatttggca ccttgtttcg tatacagctc aaaccgctct 1969441 ttgccgacca caagcaaatc acgttcagct gatttcagca ggtgctcaac cgtttgttta 1969501 ttccggccgc agtatggcat atttagctct ttagaaagct gctttgcagt ttttatggtg 1969561 tgttcagacg gtctatagct tgttgttatc atcttctgta ctcccaaaaa gaaaatgccc 1969621 ggagaacggg catttagcag tgcgcatcga aggcagcagt cagatttttc atgatttctt 1969681 ccatatcgtg tccttcaatt tcatgacgcg gaataaaatg tacgacttct ttgcctttca 1969741 aaagagccat tgatggtgaa gaaggctcct ggccagtaaa atactcacgc attttcgcag 1969801 tagcttcttt atcttggccc gcaaatacag tcaccgtatt gtcaggtgtt ttgtcattct 1969861 ggaggactgc ctgtgtagcc gcaggacgcg caaggcctgc cgcgcagccg catacagagt 1969921 taacgactac aagagttgtg ccctctgcct tttccataaa gttttctact tcttccgctg 1969981 ttgttaactc ttcaaaacct gctccagtca gctcgcggcg catcggtacg acaagctggc 1970041 gcatgtattc ttcataagcc attgacataa aaaaagcccc ctctagtatc cttcatctga 1970101 agtaaaggat actatagaga gggccggatt tcaaatgttc acgccttaaa ataaaagaaa 1970161 gtgtccccag ctatctagat tttcataata ccgccggtgt tggcacttgt cacaagttta 1970221 gaataacgtg ccaggtagcc ggttttcact ttcggttcaa aacctttcca gttcgctttt 1970281 cgtttttccc actcttcttc tggcacttgt acatccaaga tgcgtttttc aatatcaacg 1970341 ataatatggt ctccgttttc aacaaaggca agcggcccgc cctcagcggc ctcaggtgat 1970401 acgtggccga ttgagaggcc acgggaggct ccggaaaaac gtccgtccgt aatcaatgcc 1970461 acttttggcc cgagtcccat tccaacgatt tgggatgttg gcgccagcat ttccggcatg 1970521 ccaggtccgc cttttggccc ttcgtatctg atgatgacaa cgtcgccttc ttttactttt 1970581 cggttgataa tgccgtcaag cgcctcgtcc tgagaatcga atacgacagc cggcccttcg 1970641 tgtcttgtaa tcccattctg tacgccgcct gttttaatga tagcgccgtc cggagctaga 1970701 ttaccgaata aaacagcaag gcctcccttt tcagtgaatg gttgatccag cgggtgaatg 1970761 acgtcataat cctttacttc atgtccggca atggtttctc caagagtttt tcctgtaaca 1970821 gtcagcgcat ctaaatgaag cgctccttct ttcttcgaaa gctcattcag agccgctgaa 1970881 acgccgcccg cttcgtgaag atcttcaata aacacatccg atgcaggcgc cagcttagcc 1970941 aagtgcggca cgcgctcagc gacttcgtta atgcgttcta aagagtattc aacgccggct 1971001 tcgtttgcaa gggcaagggt atgaagaacg gtatttgtag aacctccgag cgccatatcg 1971061 agtgcaaacg cgttatcaat cgcttttact gtaacaatat cacgcggttt gatatctttg 1971121 cgaatcgttt ccattaattg cgcagccgat tttctcacaa actctttgcg ttccggagat 1971181 gttgccagaa tggttccatt acccggcaaa gcaagaccaa gtgcttctga cagacagttc 1971241 attgagttcg ccgtaaacat gcctgagcaa gacccgcacg ttgggcatcc gaactgctct 1971301 agttcttgaa gctcgttttc gttgattttc cctgcttggt aggcgcctac cccttcgaat 1971361 actgaggaaa gggagatttt tcgcccgtca cttgttcttc ctgccgccat cggtccgccg 1971421 ctgacaaaaa tcgtcggaat gttgatgcgc attgccgcca taagcattcc cggtgtgatt 1971481 ttgtcgcagt tcggaataca gaccattccg tcaaaccagt gtgcggatac aaccgtttcc 1971541 acagagtctg cgataatttc acggcttggc agcgaatatc tcataccgat atgccccatt 1971601 gcgatgccat catctacccc aatggtatta aattcaaacg gaacgccccc tgcttctctg 1971661 attgcttctt ttacgatttt cccaaactcc tgcaagtgaa catgaccggg aacgatatca 1971721 atgtatgaat tacacaccgc aataaacggc ttgccgaaat cctcttcttt tacccctgct 1971781 gcacgaagca aactgcggtg cggagctcta tcgattcctt gtgtgatcat attactgcgt 1971841 aattctgcca tggtgatcct cctaaattct ttcaattgtt tgattggatt ttattttgac 1971901 aattttcagt ttatttatgg gctgtttttg caaataagat aaatacaggc cgccctcacc 1971961 ttgttttgtt ctttcgtgtt tttatattta tatagctttc tttcgatttg aaccctccaa 1972021 ctattaatat tgttacttac tataaatagt tttcggatat ttttcaacaa tattcgaaat 1972081 aatttttata aaaagtgaat tcacataaaa aaggtgcatg atctgcacct tttttatctt 1972141 tattcgcctt tttttctgct ttccgtcatt tgtttccaaa cagaaccttt tgcttcttct 1972201 ccatgctcaa tacgttcaag cgccattttg acttgaaggc tgacctcaaa ttcggggtca 1972261 tcttcggcag cgcgcaaagc ttcaattgca ctttcatcgc cgacttcgta caggaacatg 1972321 gcggcacgcc agcgaacaag cttgctggag tcgcttaatg acttgatcat agcaggaatg 1972381 gcttgaggat cgccgatatc agacaggcag tctccggccg ttcttctgac tgatacagct 1972441 ttgtcctcaa gtgctttata caatagagga agaacatcag gtgtttcaat cattcctaag 1972501 tacacaacag cctgtcttct gatggacacc tttggatcat ccaatgcctt ctgtaaaacc 1972561 gggatatcct cttctttcgg atccatctgt tccaagtgtg cataacgctt tttccagtcc 1972621 tcatcatcca gcatatcaag cgttacttta tacgctttgc gctgtacagc ttgttttgct 1972681 tcgccctttc cttgagcggc tgcttcagtc agtcgtttca gccgttcatc actgtatgcc 1972741 gcttgaagct cttctgtcac atcatggccg atttcatcaa agtcaccgaa tctgacacct 1972801 tgttctttcc aagcccgctc aaacacaaca ttggaagctt cagatctaag ttttaagatc 1972861 gcctgctgaa agcgttcagg taagccgaag cgttcttccc gctctccatc ggttaattta 1972921 acttgcatag gaatgccgct gaacatctgc acaaaaactt ttacctctcc aaaagattct 1972981 tgatcagaac gattttcttc tgcgctttca gcactttcca tcccaaatgc agtgcggact 1973041 tgcggtaaaa tgtctttcca gtcgtatctt gcattccgtt caacagcaag aaaatctgcg 1973101 acgtgatata cccctttaac tccatctatt ttaaggattt ccgctataac aagcggtgcg 1973161 ccttctgctt gctcaggttt atagttattg cttttgcccg ccggaagctc ttccgttaag 1973221 atgactttca ttgtattcgg gcttggtgta ggttcaattg attttatctt catgatcgtc 1973281 ctcctatagc atatctgtga cttattctat catagtcgct ccaagccttc tattacgacg 1973341 tttcggcatc aatcccgggt atgtcttttt ctaattggcg gacaaattga agcataaaat 1973401 tgtgtctttc ttctgccagt tcccgtgcag tgtctgtatt catcatatct ttcagccgca 1973461 gcagcttatg aaaaaaatga gcgtaggcgc tttgctcatc tccataaagg ccatgccctt 1973521 ttgcgcccgc aaacatgaaa gctctcgcaa tgccgacagc accaatcgca tcaagtctgt 1973581 cagcatcctg tacagctttt ccttcaattg agagcggctc cttcgccaat ttccccctgt 1973641 cccgaaagga catccttgtt ataatatgaa tcaccctgtc agcattctct tttcctactc 1973701 cgaaaaaaac gagctgatca tatacttcgc tcacagaaag cctgaccgtg tcaggcagct 1973761 tcacatcaat taaatcatga accaaagccg ccgtttcaac aatgaacaaa tccgcttttt 1973821 ccttttctcc aatatacgct gcaagatctg ctactcttga tacatgatgc cagtcatgtc 1973881 cagagctttc gtcagtcagg atagattgaa cccatgtcct gatttgctct gcctgcttca 1973941 attccttcac aaaaacaccc tctttttatt gctctaatag cttcacgata tcgtcttcca 1974001 actctttcgg atttgtattt ggtgaataac ggccaacgat ttctccattt ctatccacta 1974061 taaatttcgt gaaattccac ttgatcgcct tagttcccag catccctttc gcatgttctg 1974121 tcaaatacac aaacagcggg tgggcgtttt tcccgtttac atccactttt gaaaacatag 1974181 gaaatgtaac accgtaattt gtttcacaaa attcctgtat gtcagcctct tcaccaggct 1974241 cttggttcat gaattgattg caggggaacc ctaagatctc cagcccctcc tgctgatatg 1974301 tatcatataa ttcctgcagc tgcttcaatt gggaagtaaa accgcactta cttgctgtat 1974361 tcacgatcat cagtaccttt cccgcgaaag gctgaagtgt catgtctttc cctgtgattg 1974421 tacgtacctt catatgataa atagacatgt aagtccctcc tatgtccttg gtgctgatta 1974481 ttttaccttt tttaaatcgc aattcaaaat gtaaacatca attaagaact cataagaaac 1974541 ctaacgatat gagcgtcagt tcattatcaa ttcatatggc tcgtttttta tcttatcatt 1974601 ctataaaaca ttacaattcc ctcttacatc tttgaaaatc attttactgt gaaaccaaaa 1974661 ggcgtgtcag tgcgttttat ttaaagagtt ttctgttgtt tccccctcaa cacgtataga 1974721 tagattgaaa attggcgtga aaattcctat aatgaagaaa attaaacggg gaaataatgg 1974781 aggtggcacg ttgcctatta atataccaac acacctgccg gcaaaacagg tgcttgaaag 1974841 tgaacatata tttgtaatgg atgaaagcag agcatttcat caggatatcc ggccgcaaaa 1974901 aattattata ttaaatttga tgccgaaaaa aatccaaaca gagactcagc ttctcagatt 1974961 gcttggaaat tcgcctttac aggttcattt cacattttta atcccaagca cacacacgcc 1975021 gaaaaatact gcgagagaac accttgacga attttacacg actttttcca atatccgtca 1975081 caagaggttt gacggcatga ttatcaccgg tgcgccgatc gagcatttgg cgtttgaaga 1975141 ggtttcatat tgggaagagc tcaaggaaat catggagtgg agcaaaacaa atgtcacttc 1975201 aaccttgcat atttgctggg gtgctcaagc aggtttgtat taccattacg gtgtggaaaa 1975261 aattcaaatg ccgaaaaaaa tcttcggtgt gttcgaacat accgttcttt caaaacacga 1975321 aagattggta agaggttttg acgagctata ctacgtgccg cattcccggc atacagatat 1975381 aaatatggaa cagcttcaag cagtgcccga gttaaacatt cttaccgcat caaaggaagc 1975441 cggggtttgc ttaattgtgt ctaaagacga aaaacaagtc tttttgacag ggcaccctga 1975501 atatgataca aatacgcttc ttcaagagta tgaaagagat ttggaacgaa acctttctac 1975561 tgtcgaggcc cctaaacatt attttgcaaa aggcagcaac gagccagtga atcgctggaa 1975621 agcgcatgcc acattattgt ttatgaattg gctgaattat tacgtttacc aagaaactcc 1975681 ttatgaatgg gactaatttt tcttttttta gtgatacgct gagcaaaaaa tatgataaaa 1975741 tacatctgat tcagtctgcg tataacaaaa atttaaaata ctggaatcca aatcatttaa 1975801 aattagctta actttttcac tgcattaata attcgattat gtatttgtgt tatgtttatg 1975861 tatagacaat aactccttac gatgcatgaa gcttgcttgt tgttgattac attgaggtga 1975921 atttacttga ataccaataa aagagtatta attttgactg caaattacgg aaatggacat 1975981 gtgcaggtag ccaaaacact ttatgaacaa tgtgtacggc tcggctttca gcatgtaaca 1976041 gtttctaatt tgtaccaaga gtcaaatccg attgtttcag aggtaactca atacctttat 1976101 ttaaaaagct tctcaatcgg gaaacagttt tatcgtttgt tttattacgg agttgacaaa 1976161 atctataata aacgtaaatt caatatttac tttaaaatgg gtaataaaag attgggcgaa 1976221 cttgtcgatg aacatcagcc cgatattatt attaatacat ttccgatgat cgtcgtgccg 1976281 gaatacagac gccgaactgg aagagtcatt cctaccttca acgttatgac tgatttttgt 1976341 cttcataaaa tttgggttca cgaaaacgtg gataaatatt atgtggcgac agattacgtg 1976401 aaggaaaaac tgctggagat cggcactcat ccaagcaatg taaaaatcac aggaattcca 1976461 atcaggccgc aatttgaaga atccatgcct gttggcccga tatataaaaa gtacaatctt 1976521 tcaccaaaca aaaaagtgct tctgatcatg gcaggtgctc acggtgtatt aaagaacgta 1976581 aaagagctgt gcgaaaacct tgtcaaggat gaccaagtgc aagtagttgt cgtgtgcggg 1976641 aaaaatacgg ctttaaaaga atctttgagt gcgcttgaag cggaaaatgg tgacaaatta 1976701 aaagttctgg gctatgtgga gcgcattgat gagctatttc ggatcacaga ttgcatgatt 1976761 accaagcccg gcggcattac tttgacagaa gccacagcca ttggagtgcc tgtcattctg 1976821 tacaaacccg tgcctggcca ggaaaaagaa aatgcaaact tctttgaaga ccgcggagct 1976881 gccatcgttg tgaaccgtca tgaagagatt ctcgagtcag tcacttccct tcttgcagat 1976941 gaagatacct tgcatcgcat gaagaaaaac attaaggacc ttcatttagc aaactcctct 1977001 gaagtgattt tagaggatat cctgaaggaa tcagaaatga tgaccgccaa acaaaaagcc 1977061 aaagtgctat cgtaatggcg tacttgagag catacgaaaa tcgtgtgctc tttttattta 1977121 tattcagcca tcaataaaag cggttacatt tttttatgga acttgccctt cttttgaaaa 1977181 ataagccgtt tcgcaacttg acgggtgctc ccagatggtg tatagttgaa ccatcattta 1977241 acaatgaatc aaagttagat gatgacaaaa ttttttttag cacatgggtg ctacagtact 1977301 aggaggaatt aagcaatatg caaaacggta aagtaaaatg gttcaacaac gaaaaaggat 1977361 tcggcttcat tgaagttgaa ggcggagacg atgtatttgt tcacttcaca gctatcgaag 1977421 gagatggata caaatcatta gaagaaggac aagaagtttc ttttgaaatt gtcgaaggta 1977481 atcgtggacc tcaagcttct aatgttgtaa aactctaaac tcaatacatg atgatgagat 1977541 gacaaataga ggagaggcat tcgcctctcc tatttgattt tcatctggat ttcaatcgcc 1977601 aaaatgtttt gtttacacct ctgttcaatc tcttcaacat acttttccat tgatggtttt 1977661 ccttttttcg cgatatcggc cagttcttct aaatcactgt atatttctat aaatgttttg 1977721 tgaaggatca acttcaagtc tttatcatcc atagctgcgt tccccttctc tatcaagata 1977781 cctcaaatag taaaacggtc ctatttattc tggttcaata gttatatcgg cttattttta 1977841 ttttcttttc tattttggta cataaatttc aaaaaaactc tgcaaaataa tggcggaggt 1977901 gttttttgtg acttcagaat ttcataatga ggatcagacc ggctttacgg ataagcggca 1977961 gctggaacta gcggtggaaa cagcgcagaa aacaacagga gccgcgacga gaggccaaag 1978021 caaaacatta gtcgactctg cataccaagc cattgaggat gctagagaac tgtcacaatc 1978081 tgaagagctg gcagctctcg atgatcctga atttgtaaag cagcaacagc agctgctaga 1978141 tgacagcgag catcagctgg atgaattcaa agaataaaaa ccgcagcttc tgcggttttt 1978201 atttttagtg attggttaag acatctccgt attgtttcaa cttttcacca accgtacatt 1978261 tattgataca aaatgaatgc gcataagttt tgccaaattc tttgcgaaac tgcttcttaa 1978321 taaaacagtc cttgcaatat tcatcgtgca gttctgtcag ttctttaaag atcattttct 1978381 tatccaatat cgtcatctcc gttacggtct aatttcgtgt ggctttctac gaattgatgg 1978441 gatagaattt ttttagcgag gccgtcagct tcctgattgt cttttcgttg tattgtttcg 1978501 taggttggag taagcttcag cgattcaagg agtgcttcta ttttgtccag ccattcatta 1978561 tgagatggat cataacaagg ccagctgccg tcaagctgat tcagcacaac aagcgagtcc 1978621 cctttgattg taattgaatt tctgcttgcc ccaagctctc ttacttctct tattgcttca 1978681 taaagcgctg cgtattcagc ttcattattg gttttcagcc ggaagctttt attttttctc 1978741 aagcgatgcc gggttcctcc caatgaataa tagatgacga tcccgagacc ggccagttcg 1978801 ctctctttat cgaaactgcc gtcaaaataa acagtaatgt catcaggctc ttgagcaagc 1978861 tcctctgtca gcttttccaa ttccttcagc gtccagctgc cgcctttctc gtcttcgaac 1978921 tctagctcct tcatgtatgg aaaacggcca agttctctgg cgaacgtacg tgcctgctgt 1978981 gctgtcagcc agtcttcgct aaaaaatgag acggatcccg ttccttttgc ttctattttc 1979041 aaatgcggtc tgagcttcat tacaatcacc ttaccattca ttagttgccg ggcttatgct 1979101 ataatcaaac caatcttacc ccggaaagga agctttttca tcttgtttaa taattcgttt 1979161 tggatctttt ttgcgatcat tcattttatc attgttcttt tattttataa aggatttggc 1979221 aaaatgggac tgtttgtttg gatcggtttt gcgacagtct gcgccaacct ccaagtcgtc 1979281 aaaacagtcg aactgtttgg cttaacagcg acactcggga atgtgatgta tggcacaatc 1979341 ttttttgcga cagatgtgct gaatgaaaaa tacggaccag ctgaagccag aaaagcggta 1979401 tggctcggat tctcaacgct cctgacgctg acatttgtca tgcagggcgt gctgcttttc 1979461 gaaccggctt ccagcgacat atcacaaaca gcgctggaaa cgatcttcgg attccttccg 1979521 cgagttgcgt taggaagtct gcttgccttt atcttcagcc aaacgctgga tgtttatgta 1979581 tattcggcaa ttagaaggat atttccttct gatcggcttt tatggctcag aaacggcggc 1979641 agtacagcag tcagccagtt gtttgataca ttcatattca ctgcagtcgc ctttctcggc 1979701 atttatccgg cagacgtgtg gcttcatatt tttatttcta catatttgat taagtttgcg 1979761 gtatctttaa tttcattgcc ttatgcctat gcagccaaaa aaatgatacc taatgatgaa 1979821 aggagttcat aatgcctaca gaaatatatg tagacggcgc aagcgccggt aatccagggc 1979881 cttccggtat cggcattttt atcaaacatg agggaaaagc agaatctttc tctattccaa 1979941 tcggagtgca tacaaaccag gaagcggaat ttcttgcatt aattgaaggg atgaagctat 1980001 gtgcaacgcg cgggtatcaa tcagtttcct ttcgaaccga ttcagatatt gtggaacgcg 1980061 ccactgagct tgaaatggtt aaaaatataa cgtttcaacc gtttgtagaa gagatcatcc 1980121 gattaaaagc ggcattccct ctttttttca tcaaatggat accgggcaag caaaaccaaa 1980181 aagccgatct tctggcaaaa gaagcgattc ggctgaatga aaagaattaa atcttgatca 1980241 ttggttcatc ctaatggcga ggtgaactaa catgaaaaag aaagataaag gccggctgac 1980301 cggcggtgtt actccgcaag gcgacctgga aggcaataca cataatgacc ctaaaacaga 1980361 gcttgaggag agagcaaaaa aaagcaatac aaaacgctag agaggatcta aacgatctct 1980421 ctagcgttca gcttttcaag catacgctca attcctttaa tttggtggcg gcgaagcatg 1980481 tcagccgcct gctccatttg caaagtaaat aaagcgtctt tcagtgtgca ggccagcggc 1980541 actgagcaat ggatttccgc aagcttcctc gacatctcca aatcgcttaa accttgctga 1980601 atttttccct gctgtccttt tggaagaaga gaaagatttt ccaataaacg gtcaatcgtt 1980661 tcgtattcac gaatcagttt gtaggctgtt ttttctccaa tgcctttgac tccgggatag 1980721 ttatcactgg aatcacccat aagcgcttta atatcaatca aagccttcgg cattacgcct 1980781 gtttcttcat aaaaagtctc ttttgtatag actttataat ttccgattcc tttttgaagc 1980841 aaagcaacgc ttactttatc cgttaacagc tgaagtaaat ctctgtcccc tgttaccacc 1980901 gtaatgtccg cttcattcgc aaataaatcg gcaagagtac cgatacagtc atccgcttca 1980961 tagccggcaa agccaatatt catgattcca agctctgcgg ctgcttcctt tgccaaatca 1981021 aactgcggaa tcagctccac aggcggcgcg ctgcggttgg ccttataatc ttggaacaag 1981081 tcatttcggt acgttttgct ccccatgtcc cagcagcaga cgacgtgtgt cggctggaat 1981141 gtttccacag ctgtaatcaa atgctttaaa aagccgttga cgccgttcgt cggcaccccg 1981201 ctgtcattta tcataaagtt gcgatgtacg gccgtggcaa aaaaggcccg gaataaaaga 1981261 gccatgccgt caaccagcaa tagtttatta ttattcatca aataactccc ttttctttca 1981321 ttccttctat tttatcataa agcagcccaa aaataaaaaa cagtatctct ttaattagag 1981381 atactgtttg aatatttatc aatcgttgtg tcttttgttg ctggcgatca gcttttcagc 1981441 ttcgcgtcct gcgtaagagt caaaatgggt ttgaaatccg tttttctttt tggcgttgtt 1981501 attcgcctgt gcatttctgt ttccgagctt tgttctgccc aacatgaatc cccccttacg 1981561 tcggatgcat atagtatatg cttccggcag gaggttcact cgcgacagga tcatccagct 1981621 tacatgcggc ttacgtattc tctgaccatt tcttttgata caagccgtct tgtcgggacg 1981681 atgccttttt tagcgagctg attcatttgc tcggtaattt cattaattgc atctgtagta 1981741 taaggctcat cgtttctgca tttagcaaca gcttcttcaa tcgccaattc acgcatattt 1981801 tcaagacgca taaatgcttt gatatgctcg tgctgttttg atgaatgtgc tgaaattgct 1981861 ttatgtacct ctgacattaa tcgttcatct cgcttttttc tatttagtct atcatgactt 1981921 gaaatacaag ccaactgaat tttacatttt tattgtattg tctgaatttt tccaggagat 1981981 gcacgcctga tacgccattt caatctcttt cgcatgttcc ccttccgcat atcctcttaa 1982041 atatgtctct ttttgatccg ttatttgcgc gattgctttt tcacccatat cttcctgtaa 1982101 gcgtctgagg tgagcagtgt aatgagatat caggctttct tcttcatttt ttatccatgc 1982161 ctctgtgatt ttcgtaagtt tcatccgtac agcttcgata aaggtcgctt ttcctttctg 1982221 ctcaaaaaac tgcttcggtg atttgatctc ttttagttcc tgctcaaaag cacgttcttc 1982281 tatttccggt tcaacttcct tcaactgtat gccgttcgaa tgctgatcac ccgcataaac 1982341 ggaaaaataa ccgtcctcgt ttaatgtttt ttgaaaatga tccagccatt cttcattgat 1982401 atgccgttcg atgaaaccgc tcatgcgaac atcaagcgtt ttgatttcct gaatatattc 1982461 aaatagatat tcatgtaagg ctgttgtcat cgctttactg acgttctttt tccaatcccc 1982521 gttttgcagc ccgggatgaa atgccgattt taataaatca tttgcaaaat atgataatcg 1982581 ctgtgcaatg tgatatagct gctctcttgt atcttttttt actttttcaa tgatggtttt 1982641 tgagttccgc cgtttctcga tatcggccgc tgtccgctca aatgacagca taaggcactg 1982701 tttctgcgct tccttctctt ctcgggactg atgctgggat tggtgaagct gaaaaacagt 1982761 ttcgcatagt ttgtctgcct ccgaactgag ctgcgctgct gacgcttttt ttacatccac 1982821 ttcgataaac cggtctaagt gttttcttac tttcgagaac tgattataaa atgactccgg 1982881 ttttcccacc agttcctcct tacttgatac ggtaaagagc tgcggctcat aaaccccttc 1982941 ttttacaagc tctgcgctga cataatcggt cactgtttcg agctctgttt tatcttttgc 1983001 aaggtctgca gcattaataa taaaaaacat tttatccatg ctgagcgatt ctttcacaag 1983061 tccaagcttt cgcaaaaatg aacggtctcc ttttgaaaaa gagtgctgat aataagtcat 1983121 ataaaaaaat gcatcagcat ctttgatata ttggaatgcc agttctgtat gccgtttatt 1983181 catgctgctc gcgccgggtg tatcaacgat cgtaatccct ttttcagtga gcgggcatgt 1983241 atagtagacc gttacctctt tcacagcaca ggccgttgtt tcctctgcta catacggctt 1983301 taattcagag agcggaatcg ttaatttctt ctgttcctgt atatactgct gatacttctc 1983361 gtatgcaagc aggaaattgc tgatcaattt cacgtgttct tcctgcagcc tgtttttttt 1983421 gactgccttt tcccacttct ctgtgaagga acggcctgcc ggctcctttg gtattccggt 1983481 gagctgcaaa atttcagccg ttaagtcatc ctctgtctta aacactacat tcgctgtttt 1983541 gtttaagttg ccattgattg gctttgtgat cttgttaatt gtcgctgtgg ttggcgttgg 1983601 tgaggatggc agcactcttt cgccgacaag cgcattggca aatgatgatt tccccgagct 1983661 aaagcctcca aaaagagcga gtgtaaattt ccgttcctca agccttttca ccctttcacg 1983721 aaacgctgaa gtttgcttta acaacatgct gcattcgcct aaaatgtcag acaaagtgta 1983781 aaagcgtttg atttggtctt gaagcggcat ttcttgttcc attttgattt ctgatttcgg 1983841 catcggctgc gccgtcagct ggcttcggcc ttgtttctgc tctggagccg ccactcttgt 1983901 tttcttcgat ttaaaccatt ctgtgtctat atgcattggg catgcggact cttcttccca 1983961 aatggcccac aggcgatcgg ttttctctcg ggcattattc tctaaacgtg cctgttcttg 1984021 aagaaagaca agtttttctg attcttggac gagccggtcg ttaattgttt gcacatcttt 1984081 ggaaacacgc tctttcacca tagcggagag cacctttatg atgtctgcgg cttctctttt 1984141 cgcctctttc cggatgagct ctgccaagtc ttttgtatat tgcaatacat attcagagga 1984201 aaaggctgca ccatgcttga ccgcgtgttc aatgatgctt atatcaagcg gtgtgcgata 1984261 ggcctgaatc agcttttcac tttcagcggt atagacatca aataccttgg cgagtttatg 1984321 aagcgtgtct atcatatgcc aatccgcttc ggcctctgtt cgttttgcca catcagagaa 1984381 aaaagcattc cgccttttat ctctttcctg tgcagttttc gctttagaaa agaaaaagcc 1984441 ggttttaaag gaaggctctt gtgattctaa aaatgcagcc gccaattcac gcatttcaaa 1984501 aggcgtcagg ttggcgtttt ttaaaatacg attgatttct tcctgcatcc tcttctctgc 1984561 ctcagtcatt tgtttttcgg cctcatccaa ttgatcacgc agcgattgga ccagtccagt 1984621 atggatatta agctgttcag cgaaactcgg agcgcctgtt tcgtctttct tcagcatttc 1984681 cgtatgttcc tttagcagat tacggacttt ttgttcggtt aaagcctgca tattgctttt 1984741 tgattgctgt tctattctgc ttaactcttc tctcagggcc cccatctgat tgaacgggtg 1984801 atccggttct gttactgatg taaaatagag cgcttccctt gaaatccctt cattgcaaag 1984861 catctcctct acctgcgctt gatagtctcc aaatttcgtc tccgtctcat catggcggtc 1984921 aatttgattg acgataaaat acacattcgg aatgctttct tttattgatc tgagaaactt 1984981 tacattttcc tcagcgtgca cgtgattata gtgaacgacg taaaacagcg catccgcttg 1985041 gtgaagaata gaagcagccg atagaaaatg cgcatcatct gttgaatcta tccctggagt 1985101 atcaatatac gcaaccccgg aatcgatctc agtatacctg tcaaaaattt cgacgctttc 1985161 aatctgttcc ccgtctttac aatattgctg caccttgtct ttctggtaag tcccttccag 1985221 ctcagcacac gctccgtctg ttgtatgaag ccgaactcgc ttttccccgt ttctgatcac 1985281 aacaaggtta gcgcttgtcg gaatcgggct tgtcggcaaa atattctcca ttaacaggca 1985341 gttcagcagt gacgatttcc ccgctgaata atgcccggta aacgcgatat aaacctcttc 1985401 atcagccgct tttttcatga ccgcagccag tttagcagcc ctttgttcat cttgattctc 1985461 aataaattgc ttataaagtt ccccggtttt atgcaaaagc tcttttctgt tttgatctgt 1985521 cataagtctg aacccctttg tgccgtttca attgtgaacc tttttcgaaa gatctgaatt 1985581 cattcccttt tcattttaca caagaataaa ccaaatttct ttaggagaat agaaaaaagc 1985641 cgccattacg gcagcttcta taaaagaaaa tctgcaactt ttacaagttc cagattcatc 1985701 aaacagattt attagagatt ccttttaata caaaaccaat taatacacta tatgtacaaa 1985761 ccgctccaag caaaaacagc attgtcattt gcttcaccat cctgattgag aatctttttc 1985821 aaacccattt taacatggtt gagaatgatt ttcaatcgct attttacgct gtattcctgt 1985881 aatgctttgt cttctgcgcg aattctgacg cttaacaaca cggcattgaa aatggaaaac 1985941 agacacatgg tgacgtatgc ttgataaagc agcggaatca gcaaaatttc gaggataaca 1986001 acggcatagt ttggatgttt catccattta tatggacctt tttttacaag ctctacacct 1986061 ggaacaacaa ggattttcgt attccaatat gctcctaagg aacaaagcgc ccaataccgt 1986121 acgatctgta cgcttaaaat cactgcagcg ataccgagcc accagctgga cggctgttta 1986181 ttcatcagca gcacctcggc aattaaggac aggaaaaaaa ggatatgcat cgtaatgata 1986241 tacggatagt ggctctcgcc aaattcaatt gctccttgct tctttacctt ttgttcgttt 1986301 tgcctggcca ctgccatttc tgctgctctt tgaacaatga gaatggcgat caacaaccaa 1986361 aacatgagtc aggccccctt ttcccagctg aataatagca actctgatga gaaacccggc 1986421 cctaatgcgc caatcagtcc tcgttcagct tcctttttat gtccgttctg cagatggtct 1986481 ttgatcacat acaagattgt ggctgaagac atatttccgt gcttttgcaa aatgctttgc 1986541 gcagatgaaa gcttttctga cgacagcccg agacttttga tgtatgcatc gatcactttt 1986601 tttccgcctg gatgcgccaa aaaaacactg atatcatgga atgacagctt atgtttgtcc 1986661 aaaaaaatct gtacatttgt tttgagccat ttttccacca aggtcggaat gtctcgtgag 1986721 aaaatgactt tgaatccttg atcggtaaag tcccagccca tgacatcttc tgattgtttc 1986781 atcaaaacag attgggcgtc cattatcttc ggcgcaagct tcagctttga caccctgcgg 1986841 tccgccttct ctccgcataa taaagctgcg gcaatgccgt caccaaaaag cgaggtgccg 1986901 atcagattgc tttttgtttt atcttccggc tggaatgtca ggctgcacag ctcggcagaa 1986961 atgacaagca caaaagcctc aggatacgct ttgcagtatt cggctgcacg cgcaagtccg 1987021 ctggctcctc ctgcacagcc aagcccccaa atcggaatcc gcttcgtata tggagaaaac 1987081 ggaagttcat tcataagccg cgcctcgata ctcggtgtgg aaagacctgt actggagacg 1987141 aaaaaaacag cttccacttt ctcataagga atggcttctt gaaaaaattc cggatgagag 1987201 aggcactcac gaacagccgc tctgctgtgt ttaagtgttt cttctatgta tatttgattt 1987261 ttttcttcaa agctgtgccc ctctttatac cattcaatcg gcttaacaaa ctgtctcgaa 1987321 tggatttgcc cgtttttaaa ggaggataac agcctgtcaa tatccttaaa agaatgctga 1987381 aacatatagc gggcgaactc ggccgctttc tcttggttta cattatacgc aggaagactt 1987441 gttccaatgg ataaaataaa cgccatgcga tcacctcttt gcatacattg tgccgcaaca 1987501 atctttttta tatgcaaaaa aaactccgcc gcggcggagt tagactgctg ttttttgttc 1987561 agcgaggtca gcttcttgtt ctattttttt agctttagaa aaaacgttat atacaatatt 1987621 taagacgact gcagtaaagc tgcccgccac aatgccattc gttgtaagca gcgttaaggc 1987681 actcggaagc tgtttgaaaa tatccggcac aacggtcaca ccgagcccca atcccactga 1987741 gcaagcaaca atcagcagat tttcctgttt cgcaaaatca atgcggctga gcattttaat 1987801 tccgtaagca atcaccattc caaacatcgc caccattgca ccgcccaaaa cagcggatgg 1987861 aataatagtc gtgaaagcag cgatctttgg aaacagccca aatgccatta ggatcacacc 1987921 tgtgaccaca atgacggcat tttttttgat ccctgtgagc tgaacaagcc cgacattttg 1987981 agagaatgcc gtgtaaggaa aagcgttaaa aataccgccc agaagcacag ccagtccttc 1988041 agctcgatag cctttagaca aatctatctc tgtcaaacgg cggtttgtca ggtcacctaa 1988101 agcaaagtaa acaccagttg actccacaag gctgacaatt gcaacgatgg acatcgtaat 1988161 gataggcgct gcgtgaaaag acggcgctcc gaagtaaaat ggctgaatca tttgaacaac 1988221 tgccgcgtcc gaaacattat caaattgaac ttttcccata aaatatgcga tgaaggtgcc 1988281 aatcaaaata ccgatcaaaa tcgagacgga cttgataaag ccttttgtaa aacggtatag 1988341 aagcacaatg atactcaaca cggtaaaagc aagtgcaaga ttggagagat ctccgaaatc 1988401 tgcacttcct tctccgccgg ccatgttatt catggcaacc ggcatcagtg taataccgat 1988461 aatcgtaaca acagagcctg tcacgaccgg cggaaaaaac gatacgagct ttccaaagaa 1988521 aaatgaaata agaatgacaa gaatgcctga agcgataatg ctgccgtaaa ctgttgaaac 1988581 cccatattca gatccaatcg ctatcatcgg cgatacagct gtaaaggtac agccaagcac 1988641 taccggaagc ccgatcccaa aaaatcggtt gctccacact tgcagaagtg tagccacacc 1988701 gcacataaaa atatcaatcg atactaagta agtcagctgc tcgacagtca gtcccattgc 1988761 ttttccgaca atcagaggaa cgacaatggc gccggcatac atggcaagaa catgctgaat 1988821 ccctaaagac agcgttttgc cgaatccatt tctcatgaat gaacctcctg tacgaaggac 1988881 acttttcctt cttctaaaga ctgaattctt gccaaagatt ccactcggta gcccagtttt 1988941 acaagttcat ctcttcccgg ctgaaatgac ttttcaataa caatgccgat tcccgcaata 1989001 gaagctcccg cttgcttcac aatcgacaca agcccgtgcg ctgcctgtcc atttgccaaa 1989061 aaatcatcga taatcagcac atgatcctga tccgacaggt gggtcccaga cactgcgatt 1989121 tggctttctg tttgcttcgt aaaggaataa acagacgctg tcagcaagtt gtcggtgagt 1989181 gttaacgatt tatgctttct cgcgaagaca actggcacac ccagcttcaa gcccgtcatt 1989241 acagcgggag cgatacctga tgattcgatt gtcacaattt tggtaatacc gtcttttgca 1989301 aacctagacg caaattcatc accaattctc tgcataagca gcggatcaat ttggtgattc 1989361 aaaaaagaat ccactttcaa tacctgatca gataatacga cgccttcttc ctctattttc 1989421 cgtttcagtg cttccatcct gtctacctcc gttatgagaa taaaaaaagc attgcccgct 1989481 caaataaaga gcaagcaatg ctgatatcac aaaaaaccgt acacgtgcgg ttccattgct 1989541 cacccatagt cggacattta cggtgcccgg tagaaacttg cgtgccatat ccacgcgatt 1989601 atatgagtgt tcctattata ttgtaataaa ttatatcaag attctaatct cttgcatagg 1989661 ctgaaaataa aaattcccga actttaattt tgttttttta gatatcattc gtatttcaag 1989721 gggattcgat ataaaagagt ctgacgaccg cgccgccagg cttttgatta taacagatag 1989781 agatttgaat atttgtttga taaataatca attaaatagc gaacattcag ctcttctcct 1989841 gttgcatctt taataatgtc taacggcttt ttccgttttc cgtgaatgtg caccttttcc 1989901 gtcagccatt gctttatcgg atggaactct cctctttcca agagagcgtc aaattcaggg 1989961 agatcctcaa gcattttttg tttcagctga gccgcataca tgtagccgag cgcataggat 1990021 gggaagtagc cgaaatctcc acctgcccaa tggacgtcct gtaaaatccc ctctgcgtcg 1990081 gtctgcggtg taatccctaa ataatcctgg tatttttgat tccaaagcga cggcagatct 1990141 tccacagaca cttcattgct gaaaatcgct ttttcaattt cataacggat gatgatatga 1990201 agaggatacg tcaattcatc cgcttcgacc ctgataaatg aaggttttga ttcattgatt 1990261 gcccggacaa aatcatccag ggagatgtcc ttgaactgta caggtgatgc ctcttgaatc 1990321 ttcttatagt acggagtcca aaaatgcttg ttgcggccga taaaattctc gtaaaataat 1990381 gattgcgatt catgaattcc catcgatgcg ccgtctgaca agttcgtgcc actgagtgct 1990441 tcatcaatat tttgctcgta aatcgcgtgc ccgcactcat gaatggtccc aaagatcgcc 1990501 gtccggaaat ctttttcatc atatctcgtc gtgacccgaa cgtctccccg attcagcgta 1990561 gttgcaaacg gatgaacggt ttcatcaagt cttccgccat caaaatcgta gccaagctcc 1990621 tgtaaaaaat acagactgag ctctttttgc ttttctttcg ggaacgcttt tgtaataaag 1990681 cttgtatctg gtttatttcc ggaagctgtc acctgtttaa caagagggat aatcgcttcc 1990741 ttcagctcag caaacaactg atcaagcacc tttaccgtga cgccgggctc aaacaaatca 1990801 agcaatgcat cataaggatg ctcttgatat ccccaatacg taataaaacg tttattgaat 1990861 tcaatcagct gttctaaata aggagaaaac aagctgaaat cagattttcc tttcgcttcc 1990921 tcccacgctg tttctgcctt tgaacacaga atcacgtatt ctttgtattc agcctcaggg 1990981 attttcttat tctcttcata ctcttttttc gccagttcca ctgctttttt cgtatcttcc 1991041 gacaagtcat caaatcgttc atacaggaca tcgataagct ccttcattcg atctgatgtt 1991101 tggatattga atatatctgt tgaaagctgg ccgatacttt cggcacgatc ctctgagcca 1991161 tttttcggcg cgcctgttct ggagtcccag tgcattaacg caactgcttc gctgtaatgt 1991221 gagattcttt ttaaaagatc aaaaaattct ttttcatatg tatgtatctc catatccatt 1991281 ccctccctat tctagccgtt ccattacagg ctaatggaag ggggtatgaa agtcaaattg 1991341 tttgtataaa aggctgccgg tatgttttgt ggcagccttt ttattcagtt gatcgtcatt 1991401 tgattttttg gcggaggtgt tctccgcttt ttctgcttga tttttttatc tacccacact 1991461 gttgccagcg gggttaagag cgaggtgaca ataacgcttg tcgcgataat tgcagttgcc 1991521 gactcagcaa ctggcgcaaa tgaggcattc gcttccgcta atgcatatgg cacggctaca 1991581 gccgcccctg ccgtagaaga agcggccact cccgcgacac catctccccg cgcaataaaa 1991641 cgatcaagca aaaacaaaga actgcccgat aaaatgacga cagaaactcc gataaaaatg 1991701 ccgagcagcc ctgattggat cagcattcca aaattcaagg tattgccgag cgaaaaggcg 1991761 aaaaatggaa tgatcgccgg cacaaccttg ctgaataagt ctctgagatc atgatccaga 1991821 tttccaagta tacatccaag taaaaacggg atgactgtcg ctgccagcgt ttcccatggg 1991881 aatgcggcaa gtcccgtcac accaaacgtc accatggtca taaaaggacc agattctgta 1991941 ctgataaagg cgaaagcgcc cgcatcctct tttcttccca tgtgattcat gagcgccaaa 1992001 tacagtccgc cgttcgtttc attcattacc gcgacaattg ctaaaacaga aaggcctgca 1992061 aaaaagccgg attgtatgcc atcgtcaggt ataaattgcg ctgcgatcac gccgagcagc 1992121 gccgcaaatc cgatcttccc caataataac gtgattcctt ttcttgcgat atagcctgaa 1992181 gaacgaaaat caatcgttgc tcctacgcaa aagataaaaa cacccagtat cggcagcgtt 1992241 ccggtaatca aagcacccgt aaaccctcca aagaactccg ctgttccagg cgcaaacgtg 1992301 ttgagcgccg ctccaagaaa tagcggaata atcatcattc cgccaggtac ccgttcaatt 1992361 gtcgccttga ttttcatatt gtggattctc ccatcctccg gttatgaaaa aacaattcca 1992421 cttacacttg gaaaacagcc tgcaaatcct cttttgaaca gctgcccaac tggctgccga 1992481 ctccgacggc gccagctccg gctctaagcc aatcaggcac ttcagacgga tgtatcccgc 1992541 ctgtcggaat aaaggtcacc tgcgggaaag gacccgctaa atttttcata aacggaatgc 1992601 caaacacacc gcttgggaac agctttaatg tcgtaaaacc gaatgtcagc gcttccataa 1992661 tttcgctcgg agtcaagacg ccggggatat aatgtgtctt tacaaaagat agatgttcag 1992721 caagatcagc tgaaaaaccc ggactgacaa taaactgcgc gccagcctta gcagcttccc 1992781 cagcttgctg cgcgctgatg accgtacccg cgccaattaa aatatcttcc ctattacgga 1992841 aggattcgat aatatctgat gccccggggg tcgtatacgt cacttcaact gcacgaatcc 1992901 ctttatctaa taaactctca atctgctgac aggcctcctg cttatccttt gaacgaatga 1992961 ctgcaatcag ctttgcttct ttcagacggt tttcaacgac tttggactcc atattaataa 1993021 tcccctttct tttggtgaac cgttctttga gcagataaaa aagaagctaa tttctccctg 1993081 gtcggcaaac cgtccatatc ccccggtgcc tgcacttgca aagcgccaat cgcatttccc 1993141 ctttgcaccg catccttgta cgacaaaccg tctaggatac cgctgattac accgactgca 1993201 aatccgtctc cggcgccgac cgtatcaacc acccggtcga cccggcagcc ttctagaaat 1993261 ccttcacttg tccccgtttt aaagtaagcg ccttcttttc caagtttaat agcaacaaag 1993321 ctggcacctt ttttcaaata atagtcggca atgccttcag gtgttttttc tccggtcaat 1993381 agctctccct ctgcgatacc cgggaaaaac cagtctgcaa gcccagccag atcattgatt 1993441 gtgtgtacca ttgttgcttg atcaggccaa agcgaaggtc ttacattagg gtcgaatgaa 1993501 atggtcttcc ctgcgtttct catgtcgttc atgacatgat acgtgaagtc tttcatctcg 1993561 gctgataaag caggcggaat acctgtcaca tgcaaatggc ctgcgcattg aaaataatct 1993621 ctcggatatt cagctgtagt taatgtgctt gcagctgagt ttttcctata gtaggtaact 1993681 tgcgggtcgc cttctttcac ttttgacttc agcagcagcc cggtgggatt ttcgtcctgc 1993741 gagcggatca cgcgggacac atccactccc tcttttttaa gctcttgtaa aataaacgtt 1993801 ccgagctgat cattgccgac cttgctcatc catcccattc gaaatccgag tctggcaagg 1993861 ccgcaggcga cattgctttc tgctccggca agccctttag aaaaagtgga tacttcatga 1993921 aggcctccat actcatttgc ataaaacatg gccattgatt ccccgaatgt caccgcatca 1993981 agcttcatct cttcccaacc tcctcttagt tgagggcacc taggattaaa gtgactttct 1994041 catgatgact tttgcctcta attcaatggt ttgaggcgct cctttgtcac cttcaatcct 1994101 ttttaataca cgttccatcg ccgtcctgcc catatcatgt gacggctggg cgatcgttgt 1994161 aatgcctgga ccgatcagtt tgtaccactc cgtatcatcg aatcctgcaa tccctatatc 1994221 ttgagggatg cgcaggccaa gctcttccat acagctgatg attttcagca taatcaagcc 1994281 attcaaagcc agaatcgctt ttttttgctc cggcatttcc ttgtgaaaag aacgaagctc 1994341 cgccttaagc tgctccttgt cctttacgtc aatttcatgc aatctgacaa gcccgttcac 1994401 attttgaacc gaagccattt cctgatacac agctgctctt tctgcacgag ggctgataga 1994461 ggaaatcggt tcggtaaaca gcgcgacatc agtataccct ttgctgtaca ccttctgaag 1994521 aatctctttt gtgatccatc tgttgtcagt cgttacggta tccagtttca gatccggcag 1994581 tttccggtca attaagattg ttggaatttg ctgttcagca aaagcgcgga gtacatcctt 1994641 gttttcccct gttgcgttta aaatcaagcc ctcaaccgaa tgggcttcta gctttaagag 1994701 catttcccgc tctttttcag gactgttatc tgtgttgcac accataatgc tgtatccata 1994761 ttgatcacaa acctcttcga ctcccctgaa agcagcgacc gaaaaaggat ttgtaatgtc 1994821 agccacaaca aatccgatta acttgctttt ttttattttc aaaccttgtg ccattttact 1994881 cggccgataa ttcaattctg cgattgcctt tttaatgttt ttcacttttt caggagaaat 1994941 cgcgtcaatt tttccgttaa tatagcggga aactgtcgat ttcgaaactc ctgcacattc 1995001 agctacgtct ttgatggttg tatggcctgt tgttttcttt ttcattcaag tgctcctgta 1995061 tctcatatat ttgaaaccga tttcaaaacc gttacaacaa aagaatacca taattttaaa 1995121 atttgggaag agttttttta ataatatgtc aattcattat tttttcgttg actcttttca 1995181 ctatttatcc taaaattttc tttgaaaccg ttaccaaaat attttcattc aagtgatgct 1995241 gaaatcctaa ccaaggggga aatataatgg aaaatcgtta ttctgtacat cctgaacaag 1995301 taaaacgctt tacaacagag gagcttcgca gtcatttctt aatggattct ttatttacag 1995361 aaaacaaact tacgatgtat tactcacatg aagaccgggt tgtcatcggc ggagcggctc 1995421 cagggcaaag tgaactgaag cttgatgcag gtgattttct aaaaacagac ttctttttgg 1995481 aacggcgtga aatcgggatt attaatgtcg gccagcctgg tgccgttaga gtcggcgatg 1995541 atgaatatgt gcttcaaaca aaggattttc tctatattgg aatgggcaat caggatgtat 1995601 cgttttcaag cctgaacggg gaaaaagcga agttttactt cgtctccgct tgcgcccaca 1995661 aaagctatcc gacacaaaaa gccgccctat ctgaactgac accggaccgc cttggtgatg 1995721 atgcagcgtc taatgtcaga agtctgtaca aagtcattca tcaggatggc attaaaagct 1995781 gtcagctgat gatgggaata acgatgttag atcaaaacaa caactggaat accatgccag 1995841 cacacgttca tgaccgtcgg atggaggctt atctttatct ggatcttgaa aaggactcaa 1995901 aggtatttca tttcatgggc cagccggacg aaacacgcca tcttgttgtt ggaaatgagc 1995961 aggctgtcct ttctcccgct tggtctattc attctggcgc aggaacatca aactatagct 1996021 ttgtgtgggc gatggctgga gaaaattaca catttacgga catggatctc attccaatgg 1996081 atgggctgaa ataagatggg ttatctacat gacgcctttt cattaaaagg aaaaacagcg 1996141 ctggtgacag gcccgggaac agggatcggt caaggaatag ccaaagccct agccggggct 1996201 ggcgctgata ttatcggcac atcacataca agcagtctgt ctgaaacaca gcagcttgtg 1996261 gaacaggaag gccggatatt tacatctttt acattggaca tgagcaagcc ggaagcgata 1996321 aaggattctg cagctgagct gtttgaaaac aggcagatcg acatccttgt caataatgcc 1996381 ggcattattc atcgggaaaa agcggaagat tttccagaag agaactggca gcacgtactg 1996441 aatgtcaatc taaacagcct gtttattctg acacagcttg ctggcaggca catgctgaaa 1996501 agaggtcatg gaaagattat taatattgcc tctctcctgt cttttcaagg cggcatcctc 1996561 gttccggctt acaccgcgag caaacacgct gttgccggtt tgacaaaatc atttgcaaat 1996621 gagtgggcag cgtcaggtat tcaggtcaac gcaatcgccc caggctatat ttctactgcg 1996681 aatacaaagc ctattcggga tgacgaaaag cgaaatgagg acattttaaa gagaattcct 1996741 gccggccgct ggggccaagc ggatgatatc ggggggactg cagtcttttt ggcatcacgt 1996801 gcttcagatt atgtaaatgg acatatttta gcagttgatg gcggctggct atcccgctga 1996861 caaataaaaa agctgacgaa cgatcgtcag cttttttcca ttacatcatg tgcggttcaa 1996921 caggcaagac ctttttgacc tcatcaatga tgcgttcatt ttctccgcca gcgtaaatgt 1996981 gaatcgagcc gctgtcttga ttcgagcgaa tcaggcgccc gatgccctgc cgtacacgta 1997041 acaacatata tggcagatca acttcttcga acggatcttt tttcgctccg ttgcgcttcg 1997101 ctgtaaatac aggatcgtgt ggcgggaacg gtaatgacca aatggtaaca ttcttcaatg 1997161 cgtcaccggg aatgtcgagt ccttcccata agtgaactga acaaagtact gtttcttctt 1997221 cctcttggaa tttctctact aagctgctga tttcctcatc accttcgaag aaaattggat 1997281 acggcagctc ccatgccgcc gacagctctt taaactcgtt taattcttca aaagaaggga 1997341 aaagcaccag cgttcttcct ttgtatcgtt tgattgtttc aatcgtttca gccgtttttt 1997401 gttcagcgtc catatctgtt tttgcgtata gattaatact catttgctcg tcataatcat 1997461 aaggggaatc aacagttaat gacaaataat catgaatccc aagactgtcg gcaatataat 1997521 caaacgaacc gccttctgac agcgtagcag aagaaaagat ataaggaatt ttcttagaaa 1997581 acactttttc gccaagtact tctgctaccg ttctcggcat cacgacaaag gttgattctg 1997641 cttccttttt ctccagccag ctgatcgcat ccttttgata tagagataat gaatacgcca 1997701 tttgttcaac atattcttcc actactgaca gttcgtattg atcaatcgta tacatttcag 1997761 actcaaatac aagtgcctca ccgattttat caagtaaacg gcaaagctcg tccgccgcct 1997821 ttttgacacg atggtcattt tttatttcta aacggtgtga accggctact tcctttgatt 1997881 cttcagaaag aacatagaaa aattcgtcgt ttgcgagaag cgcatcttca atcaattctg 1997941 caaactcttc tctgatgtca ttttgcagca atcgttctaa aaacaattca agagtagact 1998001 gcttcactct ataggttagc gctttttgcg cagcaaactc taacaagtgc ccctcatcaa 1998061 atacaactgc actatgatca ggcaagagcg gcagctggcc ctctcgtttg cgtgattctt 1998121 ccgtccacac atgctccata taaaaatcat gggaacaaat gattaagtcc gttgacttgc 1998181 ggtagtaatc tctggaaagt gtcagaccgc atctgtgtct catatcacaa gtcagacagt 1998241 cctgaaacga gtcgtagctt acgtcagacc actcttcatt cgatagattt gcgtactgct 1998301 tacggtcgcc atacggataa aagcgctgca tcgcctggga ctcgtggaca aatgacggta 1998361 acgactcata aagatccagc catttatcat catcagaacg ctgcattgtt ttttcaagct 1998421 tcttcaagca taaatattgc tcatgtgatt ttgacagcct tgtatcaatt ttcagatcaa 1998481 gatgctcagc cagcttagaa atatcgccct cttttttcac cagctgttca attaatgttt 1998541 catccgcaca agcgatgatg gcaggtttgc cgacatacct tgcatagctg attgcaaaaa 1998601 gaagatatac cagcgttttc cccgttccca ctccagcttc ggcgaacatg acttttttct 1998661 ctttaaacgc ccgctccagc tgaaaagcca taaatacttg ctcgtcccga agatcaaacc 1998721 ctttttcggg aaggatatcg taaaacacgt caccaatcca attgttcaat tcttcataaa 1998781 aattctttgt tttcgttaaa gaaaaaggca aacgtgatgt tgtcacctag ttccaacccc 1998841 caactattcg acattcagac caccaataat atcattttcc gctgatgaat acaataaaaa 1998901 acttggcaat gccaagtttt ttgcagttta cttacgattg atcacatgcg acgataaaaa 1998961 aggatggtct gttgaataaa tatgttctac cgctttttct aaatcagttt gcgcatgcga 1999021 aatcacagac ggagacgaat cagtcccgag ctccttcagc tcgtttgctg ttgcgtcaag 1999081 cgccctttga ataagattaa aatgttcgct gttcagcatg agatcacctc tgatggaaat 1999141 aatcatcatt gtatgcgaac ttttcatttt atatacatgc tttaccgcat gttatcaccg 1999201 aaacatgcac aaactacact tgatattccg tctccggatt atccgtctta tcaacaatat 1999261 tctatcaggg agtgatgttg acatgagtta tagaaaccga ttagatcagc attctgaact 1999321 gtttcatcac aattggacgc ggcctaaacg ttcaaagtct caagtaaacg gtcacactga 1999381 aatgtcccaa accaacatta tattgagaag caacgcgaaa gctcaccgtt ggtaacgata 1999441 gaatagggct gaaagatgaa agaagacgca tgcagagcgt cttcttttta tgcgttttct 1999501 gttttcttgc gctgcggtct tacttttgac cagtattgat aataatccgt tttaataaac 1999561 ccgttaaaga gttttcgttt cttcgttgct tttctgccat atgcttcctc aaagttttca 1999621 tttgatgtca gcatatacac agaccaagta tcaagcggct cgaacgcctg ccccatttct 1999681 ttgtacatct gctcaacggc ttttttctcg ccgagacgct ctccatatgg cgggttgccg 1999741 acaattacgc caaattccag atttgtggta aagtctttga cctgcatctg tttgaactgg 1999801 attagatctc ccaatcctgc ttcctctgca ttttcttttg cgatttgaac catgcggtgg 1999861 tctatgtcgc tagcgaaaat tgtaagcggc tgatcataat ttgccttttc ttcgacttca 1999921 agccgcgctt tgttccacag atctttaccg atccattccc aatcctctga tacaaaatcg 1999981 cggttgaatc ccggggcgat gttttggccg attagcgccg cttctatcgc gattgttccg 2000041 gagccgcaga aaggatcaac aaacgggcgg tcaggcgtcc aattggttaa ttgcaccaaa 2000101 gcggcagcaa gtgtttcttt aatcggcgca ccgccctgat cgacacggta tcctcgtttg 2000161 tgaaggcccg tccctgatga gtccagtgta atcaaagcct gatctttcaa taaagatatt 2000221 tccactttat actcagcacc tgtttcttca atccaatcat tggctttgcc ggactgcagc 2000281 ttgagctttt cgacaattgc ttttttgacg atccgctgac agtcaggaac gcttgcaagt 2000341 gttgatttta ccgattttcc gatgacaggg aatttcccgt tttcaggtat aaatgagcgc 2000401 cagttaatcg ctttcgtttt ttcaaacagt tcatcaaatg ttttcgcttt aaaagaagca 2000461 acctgaacct ttatgcggtc ggctgttcta agccaaaggt tcgcacggca gatggcaagt 2000521 gcatcacctt caaaaataac tttcccgtta tcaaccttgc attcgtatcc taaatctcgt 2000581 acttcctttg cgacaacagc ttcaatgccc atcggcgccg ttgcaattag tgtatacttc 2000641 ttcatcgtat caccctgtct tttaaaactt ttctcttttc aagataaaag ctctccttat 2000701 acgggagagc ttgttttcat cattttaaat gtaagtggtc taacgttctg taagccatgt 2000761 tttgttccat cgtactgcaa acggctcatc acctcgtact caggcggcaa tcatctatct 2000821 acagaaagca ttctgtcctt ctctccgttg aattccgtta agaaggttcc cctaccaaaa 2000881 tttgggtttc tcgctcgagg ggtttaccgc gttccactct caccatttct agtgagactt 2000941 cgtcactgtg gcactttcaa ggatactcag ccatatccga agacgtaggc ttttttcctg 2001001 ccgtcagcct ctaaagactg ccctagctta tgacttcgct aggcacgaac actacgggca 2001061 tctcagcacc gtgcgagcat ggactttcct ctacagattc aagatctgca gcgattaccc 2001121 gaacgttaag aacatgaatt attatataac aactgattac aatttacaag cgccattttt 2001181 ttcaagcgtg atcaatcata aagcttgctg ccaaaaacgt gtttttctaa gttagacagc 2001241 cgttttaaaa tatcaaagtt tgttgtgtta gattgcacag gctgtttttt gctggcttct 2001301 tcaagctgtt ttttcagctg cagattttcc tgctgcagtt cttcaatttc ttgatggaag 2001361 gtttcataat ccttaataat catatctaaa aatttgtcaa cgtcttcttg cttgtagcct 2001421 ctaacgcctg ttttaaattc tttttccaaa atttctttcg cagaaagctt tactttatca 2001481 gcaagcatct ttttcacctc gtatcgtgaa tcatcacata tattttttca gaaatctgta 2001541 cggttgtcaa atttctctct cattgttagt agctgtcttc ctccactgtc actctcaagt 2001601 catccattgt aataaagtag atgggatagc catcctgttc gcgccttttt tccgctgtcc 2001661 caagcatata cttaggggag ccttcctttt ccgggtcata taaaagcaga agcccgtcgg 2001721 acttatcaat gaagaactga tttttttgtt tgaattgaag cgggctttca taaggacggt 2001781 gagtcaggct tgcttcatag tctgcctgag ccagaactgc ttcatactgt tctttattcg 2001841 gttctttcca gttcttttcc tgctcgtaaa atggtgtgat gacagctacc tttaagtcag 2001901 ggtattcctc ctgcaaatca tatgcagctt ctgccgccca cagctcaact ccaagctggc 2001961 ccgaaattaa aatccattct aatccttcat ccaaaaaagc aatcagccgg tttttaatgg 2002021 ctttttttat gtaatacagc gccttgtcat cctgcttaaa tatccccagt tcaaacggtt 2002081 tatagcccgt tattgccaat actttcatca tttcacctgc tttaaaaaat ggggctcccg 2002141 tgggccccat ttgttgtgct gcattgttta caccatcaag ctgcacgttt tccatactag 2002201 tagtcgcagc aaggttttcc tgcttgaaaa tgctgatgcg tagccgggtc aacatttgag 2002261 aaagtgtgtg gaaagtagtg aacgtgctga aaatgctggt ggtttacgtt tgttgtatgc 2002321 tgtgggtgaa tgtgcggcac gatagtcttc gaaaacgtat ggtgttcaca gcaatgagta 2002381 ggatggacaa ttggcgccat catatgcggt ctgcagtgat gcatgataaa atcccctttc 2002441 cataaacttt attacaatac taagttatga aaaataaggg gtacatgttc tgatgcaaag 2002501 acctatttta aaagtgtgca attaagctgt ctttaaagtt tgaaaacaca aaagcaatca 2002561 aaaataccac aacaaagaac aagtaaaaaa cacccttata cataccaact ctccctttaa 2002621 aaataactaa cgtcatttta caggattcgc cgctattcta caacaaaatc aatgtgaatt 2002681 cagcaaaaaa aattcatggc gaaacaagtc gtcttttgcg ctttcccggg gaatatttaa 2002741 gaggaatatt tcctctttag ccgggcaatt ctcacatgca gtttttcagt ttctttctct 2002801 gataagcatg ccgcatcgct aagcgattgc tctgctactt gcaatgcttt tccgaattct 2002861 tttttcttat gctcaaaata tttcgcgagc tctattacag cagcgtatct gcacttctgg 2002921 ttttgcgagc gggacagctt ttcccaaagc ggcactgctt cttccaagcg gttttgtttt 2002981 ttgtacagga gcgataaatc cagccgtgca ctgtcctggt cctcaaacga tttttctata 2003041 agcctttcca actgcttgat cgcttggtcc gtttctttat gagccataaa ccatttcgcc 2003101 atagcatagg cttcactgtg ttcttttggc gcatgtgatt ctgaaaggat ttttttagac 2003161 atatggatgt acaatgaaat gagtgataac acatccattt cattatgatg caggacacct 2003221 tttaaaagat ccggctcttg cgccttgata aaatgaaagt aaagcattgg cgccaagtag 2003281 cccggtgtgt cttctagcct gcggatgccg agctcctctt tttcaaccgt gccaagagat 2003341 acacggtcca ttttgtgttt ccacaggcgt ctagctccat gcaaaagatc aaagtggcca 2003401 aactccggaa gcttcggaag tctgtcacgg atcaaggtgt gccttgtttt cacctgcggc 2003461 caatcaaagg ctttgccgtt gtaggtcaca agtgatgtaa tgtcaacctc gcttaaaaag 2003521 ctttggtaca aggcgacttc gttccccggt ttgggcaaaa gatgctgttt gactgtcact 2003581 cggtcttcat atactctcgc atgcccaagc aaaaaaatgg tattcccagc tccaccccca 2003641 agaccggttg tttctgtatc aaagaaaaag aggttgtttt tgttataccc ttttgctgac 2003701 aatgtatgcg acaggccgct ttgattccac agtgtgatca cttcctcaag ctcagaaaag 2003761 ctgtataacc catggcggtg agaaagcgga tattctactt ctctgatgag gcaatattca 2003821 tcttcgaaga tgaaaggctt catgccaaaa gcctcccact cttctaaaaa cgggatgtca 2003881 tcaaagtggt tttcttgttt gcctgcttct attttttgtt ctccttcgtc gagcgccatg 2003941 tgctttttca tccgttggag tttccctttt aatgacatat ccggcctccc tccttacgac 2004001 atttgatcca acagctgcaa aattctttcc tttgctttta tcccttctat ttccgtacct 2004061 atacaagacg gacagccgtc atgacaagga caatgtgtaa tcagttgttt cgccgcttca 2004121 ttaatgtctg aaaaacgttt aaagacttcc tccgccaaac cgataccgcc cggataatga 2004181 tcatataaaa atatggttgg caatccggta tgggctgctt taatttgaga aacaacatga 2004241 acatcatttc gatcacacat gatatacaca gggacaatat gctgcagcac attcgagatg 2004301 ccaagaagca gctgttccag tgtcttttcc ccgatgtctt catccgctgt tttgatttcg 2004361 agccaagctg cacttgtatg cagttcttct tccggcaaat gaataggtcc agacccaata 2004421 ttttcaaaag tggtcatttt tattttttta aaaatggtcg gcagggcatt gacagtgacg 2004481 tctccgtagt gcaatgacgt acggcttttt tctttcgttt tatcgatttc taataccttc 2004541 agctgaactg ccaggtttgc atccgtataa tattcgacat cgacttttct gacatacgcc 2004601 tttttatggt cccaatcgag cttctcaact tgatactgaa cgccttcatg caaataaatc 2004661 gcttcatcat gcaaaagcgt catcgcacta aaacggtcca tttcaccgat aatccttaca 2004721 tttgcaatat ccgactgatc aactataacg acattttcct gggaggcgga acgcaaactg 2004781 atgtttgacg cagggaacga ctcacttgcc caatggtacc gttcgccgtt gcggtgaaga 2004841 acagcctctt cctgaagata ctcaagaata tcactgactt ccatggctcc aaattcttca 2004901 tcagctctaa aaggaagctc ataagccgca cactttaagt ggtctactaa aataatcaaa 2004961 ttctccggat tgattcttgc agattccggc gaacgattaa agaaatattc aggatgccgc 2005021 acaatatatt ggtcaatcgg tgttgaattg gctaccatga taatcaaaga ttcaccgtgt 2005081 cttctgccgg ctcgtcccgc ctgctgccaa gcacttgcaa cacttccggg ataccccgtc 2005141 attacacaca cttgcagctg gccgatatca acaccaagct ctaaggcatt cgtactgacc 2005201 actcctaaaa tgtcgccttc tctcagtcct ctttcgattt ctcttcgctc tttcggcaga 2005261 tagcctcccc gatagcctct gattgatttt gttccaatct cttttttcac aagctcctga 2005321 atatggctta aaataatttc cacccgaact ctgcttctgg caaaaacaat ggtctgcact 2005381 ttgtttttaa ggaactcttt cgccagttca ttcacttctg cggttgcgct ccttctaata 2005441 ttcagcggtt tgttcacaat tggcggattg taaaacacaa aatgcttgcg tccgctcggt 2005501 gcgccgttgt catcgaccag ccgcatcggt ttgcctgtca gctgctctcc caattccttt 2005561 gggttggcaa tcgttgcgga agtacaaata aaaactggat cacttccata aaaccggcag 2005621 atccgcttca gccgccggat cacatttgcc acatggctgc cgaacacacc tcgatacgta 2005681 tgaagctcat cgatgacgat atacttaagg ttttcaaaca aactgaccca tttcgtatga 2005741 tgcggtagaa tggcagaatg cagcatatcg gggtttgtaa tgacaatatg acctgctttt 2005801 ctcacctttt gtctgattgc cggagacgta tccccgtcat atgtaaagct tttaatatca 2005861 atgcccattt catcaataat ttcatttagc tcgctctttt ggtcttgtgc cagcgcttta 2005921 gtcggaaata aatataacgc ccggtttgtt tcatcttggg cgatggactg caggactggg 2005981 aggttgtagc ataacgtttt tcctgatgct gttggcgtta cggtaacgat gctctctcct 2006041 ttttgcacat attgaaaagc ggaatattgg tgagtatata gttcatcaat gccccttttc 2006101 gaaagggccg ctttgattct ctcgtctata ctttcgggca taggccttgt ttttgcttcc 2006161 cgaggctcaa tttcatgcca attcacaacg ttttcatttc cttttaaatc agaaatgagt 2006221 tcagtcagtg atttcttttt cattctttac acctctttgt caagtacagt ttaccgaata 2006281 tttgtttgca tggctaggtg caaattttat acagttgaat aaaaaaagca aggcatacgc 2006341 cctgcttatt tcgcttttat tgtaaagagc tttgattcgc ctttacgagc agccttttcg 2006401 cctgccgata ccattgatcc tacagcctca ccattcatta taacgattgg gatgactgtg 2006461 ctgctcgctt tttcttttat taattccaaa tcacatgtaa tcagcgggtc accgaccttc 2006521 actttatccc cttctttaat gtgggcagta aatccttctc cgttcatatt gactgtctcc 2006581 agcccgacat gaattaacag ctcaattccc gagcgagtcc gaatgccaac ggcgtgtttg 2006641 gtgtggaaaa tctgaatgac ttcaccttca gcgggagaaa cgatttcacc gctagaaggt 2006701 tccaccgcta ttccttctcc catcattttc tgtgaaaaaa cagggtccgg tacatctgac 2006761 aggtccatta ctgtaccgtc tgccggagaa taaataacct cttctgtcac cttttcctga 2006821 attttgccca ttccgaataa ttttttcagc aatgtatttt ctcccttctc attcacttca 2006881 accgttatcc cttcattcac cactatttaa ccacactttc aattttgctt caatttataa 2006941 caacatctgg catagacgca taatctggtt aaaaaaggcg gtggcgatat tggaattcca 2007001 tgatgacaaa aagaacgaac tgcaaaagaa agaagaaatc ataacggagg caatcgacac 2007061 tctttttcaa tcctcagcgt tcggcaacct tataaacgga tttcagaacc taatcaactc 2007121 gagtttaaag gatgtgcaga cgaccataca tgtcagagaa agagatactg ggctgtatat 2007181 cgatattacc attccggcga cgtttcgaga tggcgagatc gtcgttgatg ttaaatcgag 2007241 gtatctccat gtaacactcc aagaaaaaca gaaacaccaa aatgaggcta cctttacaag 2007301 catgacaaga acggttcagc tgccttatga agttcgccaa gaagatatgg aaacgtcttg 2007361 gaacgagcag acaatgacac ttttctttcc aaaaaataag catgaatgaa cgattcattc 2007421 atgcttctat catttaaaaa agctggtaaa tccctttatt aaagatccga cctgattcat 2007481 tgcactcatt acttgacctg tcgtatccat cattttatta aaatcaaatt gcccattggc 2007541 ttttttgaac tgcgacataa tgctttgaaa ttgtgaaggc tgctgttgat taggccttgg 2007601 gataggataa gggttagaaa atacaggcgg ctgcataggc ataggctgga tcggagcata 2007661 aggctgataa taatcctgct gtccataatg ctgctgaggc agttgttgct ctaaataacc 2007721 gggtgcagcc tgctgataat atccttgcat atgctgagga taataatagc ccatttgccg 2007781 aggatagctt cgagagctcc cgttcattgc gattcccccc taaacacaac atatttctct 2007841 tctatatatg tatgaatgac ttctattgtt tgtgtcacaa gtgatgatta gcatttgtca 2007901 aattgtgtcg aaagtttaaa ttttttaaaa acagaaaaaa gtcgaatcat tatggtacca 2007961 tattttcaat acagatgaga ggggatgcac cataatgaac gtatcatact taagcaaacg 2008021 ttttgcagaa atgaagaaat atgaaacaga ctgtatgaat aaactgatgg actttgccaa 2008081 gttcctctat attcaaggac atctcagcat aactgagttt cgtaacagta tgaaggttct 2008141 cgaagcaaat ggagcagaaa gcccggcata tgagatgaat taacgtccgg ccccctataa 2008201 aaacgaaaag aagacagcct tttaccggct gtcttctctt gcaatttcat cctttactgc 2008261 gtgcaatgta taaaggactg actcagtgat gtccttgaat cgttttttat gaatatgatg 2008321 aacataagat tgaaggacca attccaggaa attatccttt acggcctcaa tttgctcttt 2008381 atgcacatat tttggccggc ggacttttat caattcaaga gcaccctctg cccagcgagc 2008441 agccagttca tcattctctt caactgcagg ctttatcgtc tcaaaaaaat cataagaatg 2008501 attactgttt tttccttcct gataccgatc agcgcctttt tcagcaactt caatcatttg 2008561 ctcggtcatt tccagcaaag tttgtgatag caatatcttt cacctcaatg cctatcgtac 2008621 caaatttcac tcacaaattc agccgatgcg gtataccttc tcaaacgcat acctgtgttc 2008681 aggcgattga tacagctcat ttatacaaat atgaagatct atgatttctt cttcgagcac 2008741 acttaggcga tcgttctccg tttcccgcat ctcagcctct aatgcattta cagaatgatt 2008801 caggctttgc tcagctcgcg ttaattcatc ttctatatca gaaagcatac ggagaatatc 2008861 tgtcttgcat acataaccgg acattcgtgt acctcccttt ccttgtctct cccggttaac 2008921 attctttgct ctcaaggctc tttccttcct catgacaaaa ctagaagcaa atcgccaaac 2008981 aaacaggtat tccacgaaaa gctgaagttt tcgacaaaaa cacccgcaaa aattgtatga 2009041 tcctcctcat taatgcaaac gatacttgtg aggaggtgcc gtatgaaaac aagaccgaaa 2009101 aaagccggcc agcaaaaaaa gactgaatca aaggcaatcg attctttaga taaaaaatta 2009161 ggcggcccga accgcccttc tacgtaagaa gcaaggaatt tccttgcttc tttatttttt 2009221 cagccactgc tccaccgcaa aaagcgcatg aagctggcgc tttttatgta aataccagtc 2009281 tgtcaattca atctgcttcg gcaattcctc gcgcctaaag aacgttttct ttatctttcc 2009341 atgaaaccaa tctgttttcg ttccgtctaa tgagtggatt aactcagggt agcatgtcct 2009401 tagcatagga gatgttcttt ttgtaatccc gatcatcttt tccatatcaa aacgggaacc 2009461 tgtgtgcggc actgtgtgca aaaagtgata aaaagaggag aacaattctg gcttgaacag 2009521 caattgagac agctgctttc ccagccttat cctttcctcc gcctttgaaa agcgtttcac 2009581 tgaaatgccg taaaaaaacc catttgagga aggaaaaata acggtgttaa aatgaaacca 2009641 gtcacttaaa taaaaaggaa tcgtgtcaaa aacattcttt ttaaacgaag gattttgtat 2009701 aataggtgtt tggatagtgt tttgttcatt tataatgagg gcatacatta gccgctccgt 2009761 atttcgctca tgccaaaaac gggtccattc ttccgacata aattgtgaga cgccaaacac 2009821 atgcagcaga tgaaacagcg gtttcccaac tctttttgac cagtggtata aaagaagctg 2009881 cggataggca tccgaaaaaa taagccagtt cgctctttca taggctaaaa agaaccattt 2009941 ttgctgtctc tcacggagtc caagctgaaa cagactgcct tttaagtcag tcattgacca 2010001 gccggcatta cgagaaacga aagaagccaa aagcgaccat ttgatttccg gatgacggtc 2010061 gtaaaatgct ttataagcat ttgttcttga aatgttatcc gcgtttttca tttttgtctg 2010121 ccgctcaatc cggctcagaa gctttctgat ggcctgttgt tcttgcacgt tcattcactt 2010181 ccgtcatgat tagtttaata aggaggatga gaaagtgatt cggtatccta atggaaaaac 2010241 atttcagccg aaacattcgg tttcatccca aaacagtcag aaaagggccc cgtcttacag 2010301 taatcgcgga atgaccctcg aagatgactt aaacgaaacg aataagtatt atctgacaaa 2010361 ccaaattgcc gttatacaca aaaagccgac acctgttcaa attgtaaatg tccattatcc 2010421 aaaaagaagt gccgcagtga ttaaagaagc ttactttaaa caatcatcga caacagacta 2010481 caatgggatt tacaaagggc ggtatattga ttttgaggcg aaagaaacga aaaacaagac 2010541 ctctttcccc ctgcagaatt ttcatgacca tcaaatcgag catatgaagc aggtaaaggc 2010601 tcaagacggt atttgttttg ttattatatc cgctttcgac caggtttatt ttttggaagc 2010661 cgataagctg ttttatttct gggacagaaa agaaaaaaac ggcagaaaat caattcgaaa 2010721 agatgagttg gaagaaacag cttatccgat ttctcttgga tacgcaccca gaattgatta 2010781 tattagtatt attgaacagc tttatttttc gccatcatct ggtgcgaaag gttgattaac 2010841 gaaaggttga gatgttatgt cagatcaatt taacagccgt gaagctcgac gaaaagcgaa 2010901 cagcaaatcg agtccttcac cgaaaaaagg caagaaacga aaaaagggcg gattgtttaa 2010961 aaagaccctt ttcactttac tcattctgtt tgttttaggc gtagtcggcg gtgctgttac 2011021 atttgccgtc atggtttctg atgcgccgtc ccttgatgaa agcaaattga agacgcctta 2011081 ttcatcaacg atttatgata aaaatggaaa agagatcgcc gaagtcggcg ccgaaaaacg 2011141 gacctacgtc tcgatagatg aaattcccga tgttgtaaaa gaagccttta tcgcgacaga 2011201 agacgctcgt ttttatgagc accacgggat tgaccctgtc cgtatcggcg gtgcattagt 2011261 tgccaacttt aaagacggct tcggggctga aggcggaagt acgatcaccc agcaggtcgt 2011321 caaaaactcc cttctttcac atcagaagac gttgaaacgg aaggtgcagg aagtatggct 2011381 ttcgattcag ctggagcgca attactctaa agatgaaatt ttagaaatgt atttaaaccg 2011441 gatttatttt tctcctagag catacggaat cggaaaagcg gcggaagaat ttttcggcgt 2011501 tactgattta agcaaattga ctgtcgaaca ggctgcgacg cttgcaggaa tgccgcagag 2011561 cccaacagcg tacaacccgg tcaaaaaccc ggataaagcg gaaaaacgac ggaacatcgt 2011621 actcagtctg atgaaaaagc aaggatttat ttctgattct caatataaca aagcgaaaaa 2011681 agtggcagtg aaagacgaag gcgtcgtgtc acagaaggaa tatgaaaaag caagtacaaa 2011741 caaatacagc gcatttgttg aagaggttat gaaggaaatt gatgaaaaat ctgatgtcga 2011801 tccatctgct gacggattaa agatctatac gacattagat acaaaagcac aagataaact 2011861 agatgaatta atggacggag acaccgtcgg atttactgaa ggcatgcagg gcggtgtgac 2011921 gcttctcgat accaaaaacg gagaagtccg agcgattggt gcgggacgca atcagcctgt 2011981 cggaggcttt aactatgcta ctcaaactaa ggcacagcct ggttcgacca taaaaccgat 2012041 tttggactac ggaccagtta ttgaaaataa gaaatggtcc acatacgaac aaattgatga 2012101 ctcagcttat acgtattcta acggaaaacc gattcgtgat tgggaccgca aatatctagg 2012161 gcctatctca atgcgttacg ctctggccca atcaagaaat atacctgctt taaaagcatt 2012221 ccaggcagtc ggtaaagata ctgctgtaga ctttgcaaat ggactcgggc ttggtttaac 2012281 aaaagataat gtaacagagg cctattctat tggcggtttc ggtgggaacg atggtgtttc 2012341 tcctctgaca atggcaggtg catacagcgc gtttggaaat aacggaacgt ataatgaacc 2012401 gcattttgta aaatctatcg aatttaacga tggcacgaag cttgacttaa caccaaaatc 2012461 aaaatcagcc atgagtgatt atactgcgtt tatgattaca gatatgctga aaacagctgt 2012521 gaagacaggt actggacagc ttgcacaagt acctggtgta gaagttgcag gaaaaacagg 2012581 aacgactaac tttgatgata atgaagtcaa aaggtacaat atcgctagcg gtggcgcccg 2012641 agattcttgg ttcgttggct acacaccgca atatacagct gccgtctgga cgggaatggg 2012701 agaaaacgag gctggaaaga aatcactttc agctgaagag caaaaagttg caaagcgcat 2012761 cttcgcccag ctcatcgccg atgtcgatga cggaagcgga tcatttgaga agcctgacag 2012821 cgtagtggaa gccaccgtag aaaaaggttc taatccggca aaactggcag ggccaaatac 2012881 gccaagcgat aagaagctca cagagtactt tgttaaaggc acagctcctt ctactgtttc 2012941 taaaacatat gagaaagaag aaaaagagga aacagctaaa ctgtctggtt taaacgtgaa 2013001 atacgataaa gacaatcaat ctttaacgtt aagctggaat tacgacggag atgcgacctt 2013061 tgctgttaag caatctgttg acggcggcag ctactcggaa attcaaaaca gctctgcaaa 2013121 agaggcagtt atttcgggtg tgcagccagg atctgtatac aaattcgaag taacagccgt 2013181 cagtgatgat ggcaaaagta cagcttccac atcttatgag gtgccaaaag ctgaagacga 2013241 tgaagataaa aaagaccagc aacaaacgga tgatgaaaaa caagatgatg agaagactca 2013301 ggatgataca caaactgatg attctcaaaa agatgacggt cagacggatc aagatcagac 2013361 agatgattca acaaacgatc aagacaaaaa acaagacaat acgaacacca atccgtccga 2013421 caacaataac caagaccaat caaacgataa tgataacgac aacagtaaca accaggatac 2013481 gtcggatggt gattcgaact ctggtaagaa tgattcaaca ggttctgaca cgaataaaaa 2013541 taaaacagac acatctaata aaacacaaac aaactcatca tccattgaaa aaacaaatta 2013601 aacaaaaaag ccgtcacctt tggggtgatg gcttttttgg tacacaataa aaaacctccc 2013661 gttttaacag gaggttttat cgattcatcg catgatattt ataaaaatgc tttttcattt 2013721 cggtaatcag ctcatcaagc tgaataaagc aatggtattg ggtcggctta agaagaataa 2013781 attccactcg ttcagcccaa ttaatcggct ttgcgggata tgatttctcc ctcagttctt 2013841 gccaatcgag cgatttcacc ggctcacctg ctgtccaatg taacgaagcc agcaaacaca 2013901 caatgccctt taacatttcg ttttggtcac atctcgattt tcgtgtttga aagactggga 2013961 gaagtgatgc tttgatgtca tcccacactt caaataaaag cggaacgtat ttcccgctgt 2014021 cctcccatgg caaatcgcct tgtaattccg tgcagaaatc aaaatacacg ggattggtct 2014081 gcaaggtttt cttcatatcc gaggaactct tctggccaag actgcgcaag tattgctcat 2014141 aggaagccaa cacttctttt gcttgcgtca tcgtttcacc agtccttttt tatccctctt 2014201 ctgcccttct ctgcacaaag aaagcagcgg acactccgca cagcgcggag attgggcttt 2014261 acagtgatat ctgccgaaga aaataagccg gtgatgcgta acggaccaat cttctttggg 2014321 aaccttgcgc atcagcgtct tttcaacttc cagaaccgag tccttccacc ggcaaatgcc 2014381 caatcgtttg ctgactctct ccacatgggt atctacggct atggccggca cgccaaacgc 2014441 aacggatacc actacgtttg cggtctttct cccgacccct ggcagtttga caagctcatc 2014501 gcggtctctc ggcacttctc cgccgtaatc ttcaataatc attttactca gcttttgaat 2014561 atttttcgct ttattacgat ataaaccgat tgatttaata tcctgctgaa gctcttccag 2014621 cggaacagcc aaatagtctt ccggccgttt atatttttgg aataatgttt tggtcactct 2014681 gtttacaagt gcatctgtac attgcgcaga taaagcaaca gccaccacta attcaaaagg 2014741 attggaatga accagttcac actccgcatg aggaaacatg tcacctatct tgtctaaaca 2014801 gaattcaatt tgttttagat ttaacacgat tgtcaccttt tcactttatt gttcaagcca 2014861 attgtaaaaa ggaacctgcc ttttatactc tttttgcggt tcattctgct ttgcttgtac 2014921 acgccggaat ttttggctgt gtatttttgc ctgctccaca gttttaagcc catttttctt 2014981 ccattcaaac aaaatccggt caatgtagcg gaaactgagt tttcctgata gtacagcctc 2015041 ttttaacgcg tgtttgatca gttgtgcgtc atgctgatcc tggtcctgcc agatcgccag 2015101 cgtttcacac tccaaaggcg ataacggtct tgcgaactct tcctcaaaaa tggtataaag 2015161 gcttttttgt tccccttctg cttttctttc ctgtgtttga ttctgtgcaa gctgaatata 2015221 ctcgtacagc ttgccccata aaggctgaag agaatatttc tcaaatttga tgccgttttg 2015281 atcctcgcat tcttcaataa acagaaagcc tttttgaata aacatccgca atctgtttgt 2015341 acattcttca acagaaattg acataccttc ctgcagctga ttcggtgtag gaaaatatga 2015401 tcctttttct aaatgcattt taatttttaa cagcagaata agttctgttt cattaagccc 2015461 aagctgttta taatgcgtga gcagaagatt ggggatggtt gatgttccct gctcctgcat 2015521 atcaataaat tgctgttttt tcatcgtcac acctcttact gtaaaggatt gtgattgccc 2015581 ctttactgta aaaagtctcc cttgcaggag actctttttt gtttcatttg aatgtattac 2015641 ggatacagac ggtttaacag tcttgggaac ggaatcgttt cacgaacgtg aggcgctccg 2015701 ctgatccaag ctactgtccg ctctaatcca aggccgaagc cggaatgagg aactgatcca 2015761 tattttctaa gttcagcata ccatttataa gcgtcagaat ccagtccatg ttctttaaga 2015821 cgcgattcca aaagttccat atcgtgaatc cgttcagacc cgccgatgat ttctccatag 2015881 ccttccggcg caatcaagtc agcgcaaagc acaacgtcct cacggtcaga agccggctgc 2015941 atatagaacg gttttaagga cgtcggatag cgagtgatga ataccggttt gtcataatgt 2016001 tcagcaatcg ctgtttcatg aggcgctccg aaatcatctc cccactcgat atcgtcaaag 2016061 cctttttctt tcagaaattc aatcgcttca tcatacgtaa ttcttgggaa cggggctttg 2016121 atttgctcaa gttttgacgt gtctcttccc aatgtgttta gttcaatttt gcaattttta 2016181 agaactgatt gcacgatgaa agaaacgtaa ttttcctgta cttgaaggtt ttcttcaaat 2016241 tctacaaacg ccatttccgg ttcgatcatc cagaattcga ttaagtgacg ctttgtttta 2016301 gacttttccg ctctgaatgt cggtccgaaa gagaatactt ttcctaaagc cattgccgca 2016361 gcttccatgt agagctgtcc gctttgagac agatatgcat cttcatcaaa gtactttgtc 2016421 gcaaagagtt ctgttgttcc ttcaggtgcg cttccagtca aaatcggcgg atccactttt 2016481 acgaagcctt cgttattaaa gaattcgtaa gtcgcgcgaa tgatttcatt acggattttc 2016541 atgatcgcat gctggcgctt tgaacgcagc cataaatgtc tgtgatccat caaaaattcc 2016601 gttccgtgtt cttttggtgt aattggataa tcggtcgctt cgtgaatgac ttcaatatct 2016661 gtcacagcaa gttcatatcc aagcggagaa cgctcgtcct ctttgacaat cccttttata 2016721 tagagcgacg tttcctgcgt cactgattta gctgtttgga aaatgctttc ttccacttcc 2016781 gcttttacta cgacaccctg aataaaaccg gtaccgtccc gaagctgtaa aaacgcaatt 2016841 ttcccgcttg aacgcttatt agcgacccaa gctccgatcg ttacttcctc acctacgtgc 2016901 ttgtacactt ggttgattgt tgttttcaac atatttccct ccaaaacaag aaagacattc 2016961 ggaagctcat tgccccgcga actcttttat catcacttta ttatacccgc tcttaactaa 2017021 ccgggtcaat gcagataaaa agcggctttt ctgtcagccg ctttttgatc tgttagctat 2017081 gtttttctac aaaacgcttg attctttcaa tggcttcttc aagaagatct aacgatgttg 2017141 cataagaaag acggacattc tcaggagagc caaatccgga tcctggaaca atcgcaactt 2017201 tttcctcctc gagaagcgct ttaacaaatt catctacatc tttgaaaccg caagattgag 2017261 ctgcctcttt tgcatttggg aacaagtaaa aagcaccttc cggcttcacg cagctgaacc 2017321 ctgggatttc tatgagcttt gcatagatcg tatttaatct atgttcaaat gcttctctca 2017381 tttcttccaa tggctcagaa ggcccgttat aagcagcaat cgctccgtat tgtgcgattg 2017441 atgtcgggtt tgacgtgctg tggcttgcaa ggttcgtcat cgctttaata atgtcttcag 2017501 agcctgccgc ataaccgatt ctccagcctg tcatgctgtg ggacttcgat acgccgttta 2017561 taatgaccgt ttgctctttc agtctgtctg acagctgtgc aatggaaaca tgtttctttc 2017621 cgccgtatgt aagtttttca taaatttcat ctgacacaat caagatatca tgttcaaggc 2017681 acacttcacc gagcgcagat agttcttctt ccgtatacat gacaccagtc gggttgcttg 2017741 gagagttaat aacgattgct tttgtttttt ccgtaattgc atttttcagc tgctcaggcg 2017801 aaattttgaa gtgattttcc tcaagccctt ctacataaac aggctttccg ccagcgagtt 2017861 tcacctgctc cgggtagctt acccagtaag gcgttggaat aataacttca tcttcttcat 2017921 ccaaaatcac ttggaaaagg gtatacagag catgtttggc accagtgcag acaataattt 2017981 gagacggttt gtattcaata ttctggtcgc gtttaaattt ctctgcaatg ctgtttttca 2018041 gttcagccaa accaccggaa ggcgtgtatt tcgtatggcc ctcgttcatc gaacgcacag 2018101 cggcatcaat aatatgctgc ggtgtattga agtcaggctc gcctgctcct aagccgatga 2018161 catcatggcc tgcggctttc agttctttcg ctttcgctgt gattgccagt gtggttgatg 2018221 gtgttaatgc ggatactctt tttgccagtt tcaacttgaa ctccccctaa ttcgtcttaa 2018281 ggcgtgatat ttttgagaat ctttccagtt gtaaagtcca cataacttaa actgtattgc 2018341 ccttctttgt ctaagtacgt cacttcccaa agcaggacgt ttccttctct tgccagatga 2018401 acctcttttt gctttgaaac cagcccttca tcctttatga ttttcgccgc tttgtcttca 2018461 gagattccct ctttcgcttc ttttgagaga atttttgctt ttttatcagc aggaacccag 2018521 acatataatg cagtgccttt tttatccgtt ccctttacaa cataatattt ttcttttccg 2018581 acaaatgttt cgacttgatc aacatgggcg agatcggttt cttttttagc ttcagcagct 2018641 gctgcttcgt gcccctcttc cttttgtgcc atggctgatt tataaatgct tgccgagaca 2018701 agaagtactg ctaaaaaaat aataccaaaa atgacggtaa atattaatgc tttttttctc 2018761 atcttctcac ctacgtacga taaatggtaa aaacggcttg gtttttgttt tcttcatcca 2018821 gcgcaaggcc gaacatcaga ttgtctcttt tcagtgtacg attcaatgtg tccacaattt 2018881 tatacagatc atcagaatgc tctacattaa ttgttgaaag aatttcgatt ttactttcca 2018941 ttttttcatc ctccagtttg aacaaatatt gttagtcata ctccatttca ggacacgcca 2019001 tactagtatc acagagcggg aaatccgctt ttaaataaaa caccatccta ctcccacacc 2019061 gcaaaagccg ctttatgcgg cttttattct ttttcccctg caacataagc ttcaagctcg 2019121 ctgtcagtca tttcggatac tgaggttgtc ggcaaggcat caagaaacag ccggccgtaa 2019181 ccagcggttt taatccgtct gtccaatata ataatcgttc ccttgtctcc cgcagaacgc 2019241 agcaagcgtc cgattccttg cctgaaggtc agcacagctt ccggtaatga cactgtttga 2019301 aacggattct ttcctttttt gcgggcaagc tcacattttg cagcatgaag cgggtgatca 2019361 ggggaccgga atgggagcct cacgatcatt actgtcgtca gctcatcacc agggaaatca 2019421 acgccttccc aaaaatgatt tgttccgagc aggatcgcct gattggatgt tttaaaagtc 2019481 ttcatcagtt tgccgggact tccgcctgta atcccttgtg ccaagagctg aatgccggaa 2019541 gcactcatgt tatgcttaag ctcctggtga acctttttca gcatatcatg ggatgtaaac 2019601 agcacaagga ttttaggctg tttttccttt gccatcagtt cgatataacg ggctgtatcc 2019661 tgtataaatt caggttgccc tgtatcctga attgatttca tttcttttgg aatcatcacc 2019721 tgcatacgct catcgtaaga aaagggtgac tcaattctca ttgtccgcgg gaaaaagtca 2019781 ctcagtccca gtcgttcaat cataaattga aaagaacctt cgactgtaag agttgcagat 2019841 gtcagcacca cactattttt gcgcgcgaaa aactgatcag ccagaagttc accaggttca 2019901 agaggctgtg cgtaaatggc cactgcattt ttcgcaccct ttgcatctat ttcaatccaa 2019961 accgcttcat cgtcatcaga gccaaagaag agcttctgca acgtctgaca gtaatgctgc 2020021 aagcctttca tgcttctttg gtattcatcg gctaaaaaga cggttttgct cttcatgccc 2020081 ttcaaatgtt tttccataag ggatgactgc gcctcaaaaa gctgctgcaa atgtgtcagc 2020141 atggaacaaa gcctctccgc accatctgtt aagatcgacc agcttttatc ctggctttct 2020201 ttgttcacct taaacactag acggtttaag tcttctttag gttttcttcg tttgacaaaa 2020261 gaatgtacag agctaaagaa agcatcactt tctgcttgaa cgtgctgaag ccactcttcc 2020321 aattcgaaaa atgaatcaac cggcaggctg tttcgctgga atagctgtct catctttttt 2020381 agaagtccct gctccttcag agtgccgatt ctgctcaatt tcgtatgcaa ttctatgtac 2020441 gtggctcttt tccctaaatg ttcgcttgcc gcacgttcaa aatggtgtgc ttcatcaata 2020501 ataaatgtgc cgctttcggg aagccttttt ttatggctgc cttcatcggt cagcaaaaga 2020561 gaatgattgg tgatcaccaa atcggaacgc atagcaatct gtttggcccg ctcgtaaaaa 2020621 ccgatcacat gctcactgcg acttctttta taggagtcat cgtcataagc caatctgtcc 2020681 cacagcaatt ttccgcctga aggcaaattc agttccgcta catctcctgt atttgtctct 2020741 gtcagccaaa caagaagctg tgcctttgtc agtacggcat cataattatc atcttcttca 2020801 tgaagcacct gctcaaattt atacaggcat aaataatgcg attgcccttt taaaatcgcc 2020861 gctgttaccg gaaatggaaa cagatcttgg acaatcggca aatcctttgt gagaatctgc 2020921 tgctgtaaaa gcgtcgaata cgtgctgatt atgaccggct tttttgattt cttggcaaaa 2020981 agcgcagccg gaataagata gccaatcgtt tttccgatgc ctggaggagc ttcaatcagc 2021041 gcatgctcac gattggcaaa cgcatcagcc acctctctca tcatcatcat ttggccgtct 2021101 cttttttcat acccaggcat taactctgac agcgcttttt catttcccgc ttcccagctt 2021161 tcgatctcaa atgagaagtt ctcgtcctca tttatacgaa catcgatagc ttcaggttct 2021221 ctgacagaaa acgaagaaaa gcgcgtatag cccggtatct cggtatgtct gttttcatta 2021281 atgaacatat ccaacaaatg cgtcagatca ctgatgaaat gctgcgaaag ccttcttaac 2021341 tgctttaatg tcggataagg aagctgccgc agcttttcaa ggatttccaa aaaaataagc 2021401 cctgtcactt cagcatcgct gtcagcccgg tgcggctgat catgccgcag ctgaagctcc 2021461 tcgcttaatt ccgtcagctt atacccttca aatcccggaa aaacaatgcg tgagagctcg 2021521 acagtatcaa gcacttcaca atctgggagc tgaaagcccg ccttatgtag ctcatacttg 2021581 acaaatccaa ggtcaaaatg gatattgtgg gcgacaaaat aagcgccgtc aagcaattgg 2021641 aatacttctt cagcaactgc ttcaaatggc tgttcattct cgaccatttg attagagatt 2021701 ccagtaagct gctcaataaa agcagggatt gatttatttg gattaatgta ttttgaaaac 2021761 cgctcagtaa tttgtccatt ttcgattaca accgctgcga tttgtatgat tttatcgcct 2021821 ttcttcggcg aattccctgt tgtctctaca tctataacaa cgaaccgttg cttattcatt 2021881 aaaatggaca cctcaattct tgcatacgac aaaagtgtaa cacgttttgt acggaaatgg 2021941 agcggcaaaa ccgttttact ctcaaaatct taaaagaaaa cccccgataa agggggcttt 2022001 tcttctacaa aattgtacgg gctggttcgt tccccagcat ttgttcaatt ttgttttgat 2022061 cattcagaac agccactttc ggctcatggc ttgccgcttc ttgatcagac atcattttgt 2022121 aggaaataat aatgacctta tctccttcct gcacaaggcg tgcggctgca ccgtttaagc 2022181 atatgacgcc gcttccccgt ttaccaggaa taatatacgt ttcaagacgt gctccattat 2022241 tattattcac aatttgtact ttttcattag gaagcattcc cacagcatca atgagatctt 2022301 catcaattgt aatgcttccc acatagttca ggtttgcttc cgtaacagtt gccctgtgaa 2022361 gtttgccgct catcattgtt cgatacatat tatattctct ccatttctcg aatatcaata 2022421 atgatattat ctattaaacg cgcttttgaa aaagcaactg caacagcgag aatcatcttt 2022481 ccagcaattt cattcacagg ctcgagttcc ggataggaat aaagctctac atagtctatg 2022541 gttccgctag tcgtttcaat gatatctttt gcagctttta tcaccgcttc aggatctctt 2022601 tcaccggctt ggacaagttc cgcacttgtt tgaagggccc gatacagctt aggcgcttct 2022661 tttctttcct cagctgttaa gtatacattg cgagagcttt tggctaagcc gtcttcctct 2022721 ctgaccgtat cgacaggaac caattcaata tccatgaaga agtcgctgat taacccatca 2022781 acaacagcta cctgctgcgc atcttttaaa ccgaaatagg cacgagtcgg cttgactaga 2022841 ttgaaaagct tcgtcagtac gatcgcgacc ccgtcaaaat gtccttctct tgagcgcccg 2022901 cataacacgt ctgtgcgtct ttctacatga atcgtgacat tcttttcacc gggatacata 2022961 tcatgagcat ctggcgtaaa aagaatatcg actccggcgt tttctgcaag agctgcatcc 2023021 cgctcaatat cgcgcggata tgcttcaaaa tcttcattag ggccgaattg tgcaggattc 2023081 acaaaaatac tcataataac ggcgtcgttt tcttgtcttg ctttgtctgc taaggttaaa 2023141 tgcccctcat gcagaaaccc catcgtcgga acaaatccga ttgacttgcc ctctgaatgg 2023201 tattgtttta tggcttcttt cagctgtgaa atatcagtaa tctgtctcat cttattttcc 2023261 cccgtacaag ccgtcaagca ctgtctggtt catttgaaag gaatgctttt gttcagggaa 2023321 agcacgatgt cttacatcct gaacatatcc gctgattgct gtttcgatgg tttcatcaat 2023381 gcgcgtatat tgctttacaa atttaggtgt tctctcaaca ccgtggccga taatatcatg 2023441 ataaacgaga acttgtccgt ccgctttcac accagccccg attccaatga ccggtatgct 2023501 tagcgtctcg gcaattttgg ctgtgagttc tgccggcaca cattccagca caagcatcat 2023561 agctcctgct tcttcgcatt ttatactgtc ttctattaat tttttggcgc tttgttcgtc 2023621 tttgccctgt actttatagc cgcccagtac gccgactgac tgcggtgtca aacctaagtg 2023681 actgactact ggaatgcctc caagcgtcaa tgcgcgaatg gattcaaaca cgccttctcc 2023741 gccctcaagc ttcagtgcgt cagctccgct ttcctgaacg atagccgctg catttttcag 2023801 cgtatcttcc ttagacaggt gataagacat aaacggcata tctgtcacaa taaaggtatt 2023861 cggcgcaccc cttttaacgg cttttgtatg atggatcatg tccgcaactg tcacaccgac 2023921 agttgaatca aggccgagga cgaccattcc aagtgaatca ccgactaaaa tcatgtcaac 2023981 tcccgcttgt tcagcaagtt tagctgccgg ataatcataa gcggtcagca tgacaatcgg 2024041 ttcttcagac tccttcattt ttagaaaatc cagttttgtt ttcatgtttt ctcctcctca 2024101 tgtttagagg agatgatctg ccgttttctt ctgcaagcca aaaaaccttc cgttacaacg 2024161 agaaggattc ttcactttct aaagttcggc gagtttcatc cctctgtccc agtccttttt 2024221 tggatcaagg cagactgctg caatgtctat ctattttaat aataggtgca gttcgcaggc 2024281 gatactgccc aatggaagta taccaaaatc aacgggcttg taccaacaca ttagcccaat 2024341 tcgatatcgg cagaatagat ttttttaatg ccttcgttcg tttctaaaag cagaacgcct 2024401 tcatcatcta tacctaacgc cttaccgtaa aaggttccgt ttaacgttct ggctctcata 2024461 ttagtgccaa taccgagcgc atagctttcc cataaaagct taatcggcgt aaatccgtgc 2024521 gtcatataat cccggtaccg tttctcaaag catagtaaaa tatgctggat gacgccggcc 2024581 cgatcaattt tttccccagc agcttggctg aggcttgtcg cgatgtcctt caattcatct 2024641 ggaaaatcat taggctgctg gttaacgtta atgccgatcc caatgatcac tgaacgtacg 2024701 cggtcttctt cagcctgcat ttccgttagg ataccgactg ttttttttcc gttaatcaaa 2024761 atatcatttg gccatttaat atccgtttgg atgcctgctg cctcttctat tccctgcaca 2024821 acagctactg cagcaagcag agtcagctgc ggtgtttttt ggagcggaat gtcaggccgc 2024881 aaaatcaggc tcatccaaac accgtttcct tcttgagaat gccataccct agacattcgg 2024941 ccccttccgg ctgtttgttt gtcagccacc acaagggtgc cttccggtgc gttattattc 2025001 gcgagctcat gagccgtttt ttgcgtgctt gaaagaacgt catggtaaat aagatgctgg 2025061 cccatcactt ccgtttttaa tccaaaacga atttcgcttt cactgagttt tccgggtttt 2025121 ttgatgagcc gatatccttt tcttctaacg gcttctactt cataaccctc tttccgaagc 2025181 tcttcaatat gcttccacac agcagttctt gaacagccga gagcatcact gattttttgg 2025241 ccggaaataa attcattgcc ggcctgagaa aataattcaa taaggtcttt tcttaatgtt 2025301 gaccgcatgt cttcagccac tcctctatgt gtttcttttg attggagagc ttccctgtca 2025361 caacagcctg ctcgatccac tgtaattctt ctgacaccca ttttccggcc ggccggtttc 2025421 gaagcgcaag caagtcctta cccgtgatat caagatcctt aaggcttttg atcggcaggt 2025481 tttgataagc gtactgaatg tccttcagtt tcttttcatc cagtttttcg ttttgccgaa 2025541 gctgcgatat tttggccgct gagagcagtg cttttttccc agctctgtac attgtcattg 2025601 cgtcaaggct ctggccaaac gtatcggcaa tgtgaatggc ttccttgatc acttttcccg 2025661 ggagcttcca ggctttcagg aaaaggggcg cgtctttcaa aactatgcca aggttaatta 2025721 aaagagcagc ccaaagctcc tcacgggatg ttaaagagaa gaatggaaac tcactcgttg 2025781 aaatcaggtt ttctcgttta tgataaaaac caggaagctc ttcatacaat ctcgtttgaa 2025841 tgagtgtttg aagcgcctgg cgagaagctc ttccctgcag caatttctca aactctatag 2025901 tttttcgttc gactgaaaca tgggagagga gtgatttttc tttcgcaatg gcttcttctg 2025961 tttccggtga aagcgtaaag ccaagctggc tcataaagcg tacggctctc agcatacgaa 2026021 gcgcatcctc ttgaaatcta tcctcaggct ttccaacggt tcgaatcact ttctgatcaa 2026081 tatctttctt gccgccaaaa taatcaagca ccttcccgtc cgctgtcatg gccatcgcat 2026141 tgatcgttaa atctctgcgt tttagatcct cttctaatga tgagataaat tgcacttctg 2026201 acggtcttct gaaatcaaca taatcagatt cagtccggaa tgtcgtgact tcataggttt 2026261 catcctccca gagcacaata atggtcccgt gctctttgcc tacatcaaca gtccgctgaa 2026321 acagccgttc tacttgatca ggtgccgcat ctgtcgcgat atcgacatct ccgatcgttc 2026381 gtttcatata gctgtcacga actgcgcccc cgacaaaata agcctgatgg cccgcttcga 2026441 ttaagatgcg gagcacggga agtgctttga taaaaacttt ttccatgtga tcactccggt 2026501 tctgctaaat cggcataaat ctgttcatac tggctgacaa tttttttaga agaaaattca 2026561 ttttcaagca tctctattgc cgcctttgta aaacgattgc ttagctgttc atcttctaaa 2026621 atgctcatcg cgcgggctgt tgcggccgta acatcaccga catccaccaa aaatccgctc 2026681 acattgtttt ttataacctc agggataccg ccaatgtttg ttccaataca aggcactccg 2026741 caagccatcg cttcaagcag gacaaggcca aagctttctt tttcagatag cagcagcttc 2026801 aaatcgctaa tagaataaag atcttcaaca cggtcttgat ttccaagcat taagacttgg 2026861 tcttccaagc catattttct gataagctcg caggctgtcg atttctccgg accgtctccg 2026921 actaaaagca gcttcgcttt cgttttgcca gcgatattgc ggaacacacg gatgacatcc 2026981 tgcacgcgtt taacttttct gaagttggac acatggatga cgactttttc atctggtaaa 2027041 attccatgtt tctctttaat tgccgctgtg tttttcttca gatacacgcg ctcgtctata 2027101 aagttataaa tcgtttcaat ttttttctcc ggtttaatta aatcgtatgt ttcagccgca 2027161 agcgctgagg agacggccgt caccctgtct gatgactcaa tagcaaaacg gatcagatct 2027221 tttagagacg gatcataacc taacaccgtg atatccgtgc catgcaaagt ggtaacaatg 2027281 ccgatattgc gtttcagcat ttgttttgca agataggcgc aaacggcatg cgggagagca 2027341 tagtgagcat ggataatgtc taaattctcc cgttccgcca cctcagcgat tttgcttgcc 2027401 aatgtcaaat catacggagg atacttaaaa acagcatatt gattaacctc aacttcatga 2027461 aaatgaatat tgggatgata tgtattcagt ctaaacggaa tgcttgatgt gatgaaatgg 2027521 atttcatgtc ccttttcagc aagctgcttc cccagttctg tcgcaatgat acctgagcct 2027581 ccaacgctcg gatagcatgt gattcctatt tttagttttc tcattgttcg cccccaagca 2027641 catcatgatc aagcatcagc atccgtttgg aaaagaaacc ttcggcatac tccacgcccg 2027701 cttctttacc gtaaagcttt tctctcgctt caacgatttc aatataccca ttcgtcagag 2027761 gagtagaaac ggaatccttt gacgggataa actggctttt gtaggcgttg aggctttgtt 2027821 tctttgcctc tattgtatcc gagatatcaa taacaaaatc cggctgatga aaaccattta 2027881 tcatataata gtaaaccttg ctgactttat gcgccggaag gcttttttcg tctttatatt 2027941 tatggattcc ggcggaaaag atcgcttctt ccaccagtgc agccgcattg ccgtgatccg 2028001 gatggcgatc ctttttatac ggcataaaaa ccgcttttgg ccgacagatt ctgatgacag 2028061 tgacaattga ccgaattgcc tgatcactca ttattaggcc gcggtctgga agcgttagct 2028121 gaattctttt atctgcgcct aatatgcggg ctgcttcagc tgcttcttct ttacgcaaac 2028181 tgaccgtacc gttagaagag agttccgctt ctgtcaaatc gcatatcatt actttttttt 2028241 cctgtttgac aaacttcgct attgtgccgc ccattccgat ctcgacatca tcactgtggg 2028301 cgccaaaagc aagaacgtca gcattataca ttcggctctt ctccccgaag aaggtcacgg 2028361 aattcgaaaa caccttcatc aagtgtgcgc acaagaattt ccgcagtacc catatttgtg 2028421 gcgagcggaa tggaatacac atcacataaa cggattaatg ccgagacatc cggttcatgc 2028481 ggctgcgcgg tcagcgggtc gcgcaaaaaa atgacaagat cgagtgcatt ggcagcgatc 2028541 agtgcaccga tttgctggtc tccccctaaa gggccggatt gaaaacgttc aatttgaaga 2028601 cctgtcgcct catgaatttt caaccctgtg gttccggttg cgtatagatc atgattcttt 2028661 aaaatatccc gataggcagt cgtaaattga accatatcct gttttttctt gtcatgcgcg 2028721 atcaaagcaa ttttcattgt ttatcccccc gtctaatcaa tgatattttc taaaccatac 2028781 acaagctgat caatcttcat gacttgttcg actgacagtt taacgcctga catgaaagaa 2028841 gcacggttat aagaatcatg gcgtatctga agcgtttggc catccatgcc gaacatgacc 2028901 tcctgatgcg cgatcagtcc cggaagacgg acgctgtgca agcgaatacc gttttgctcc 2028961 gctcctcttg ctcctgggag aatttctttt tcatccggat gtccttgctg cttttcttta 2029021 cggacttctg aaatcatttc cgctgtttta agcgcagttc cgcttggtgc gtcaagcttc 2029081 tggtcatgat gaagctcaat aatctcaaca tcctcaaaat agttggcagc catttttgaa 2029141 aatttcatca tcagtatcgc accgagcgca aaatttggcg cgatgatggc tccgatccct 2029201 ttttcttctg ttaaagatgt gagctctttt aaatcagctt ctgagaaacc ggttgttccg 2029261 acaactggac ggactccgtg ctctaatgca atttttgtat gtacttttcc gatttcgggc 2029321 gttgttaaat caatcaagac atccggttgt gtttctgtaa aacaggcatg gatatctgtg 2029381 taaatgaaag catctgactc aacaggcatc acatcagata atttttgctg atcgtatgta 2029441 tggtctatgg cccctacaag gtcaaaatgt ggtgttcgtt ctgccaattt aacagcttcc 2029501 tgccccattc ttccacgcgg tcccgcaatg actaatttaa ttgtttcgtt tgacatcttg 2029561 atctcctcta ctttccttct tcttttctgg tccagcgatc tttatctctt gtattaaatt 2029621 tatgcatgac tcggtcgtga gcttcctcta aagagatatc aagagagttg gctaaacaaa 2029681 ccaatacaaa tagcacatcg cctatttcct cttccatgct tttatcatct tcagtcgctt 2029741 tttttggttt ttctccataa cggtgattca cttctctggc aagctcgccc agttcttcag 2029801 tcagcctcgc catcatggcc agcgggctaa aatatccttc tttaaattgg cctatgtaac 2029861 ggtctacttc agcctgtatg tctttcattg ttttatcact cactgaacga aacctcctat 2029921 catcctctta catgttagct aattcagata cgtttgacaa atgtttaagc acgtttgctg 2029981 ttttcttttt catccactat aatataaacg ctatctaatg gaaggaaaag gggttttgtg 2030041 tgatgcttgg agaaattaga ttaaaaaaca tattttttat tttaatcgga gcggcaattt 2030101 tttcatttgg cttggttcat ttcaatatgc agaacaatct ggctgagggc ggttttacag 2030161 gtattacact tttgctttat gcccttttcc acatcagccc ctctatatcg aacctggtgt 2030221 tgaacattcc gatttttttt attggctggc gtttgctcgg caggacaatg tttgtttata 2030281 cccttgtcgg cactgtagcc ttgtctttgt tcctcagcat ctttcagcga tatgaaatcc 2030341 atatgcccct tcagcacgac ttagcgctcg ccgctttatt tgccggcgta ttcatcggag 2030401 ccggactggg tattattttt aagttcggcg gtacgacagg cggtgttgat atcatcgcac 2030461 gtttagtgaa taagtatttt gggattccga tgggcagaac gatgtttgct ttcgatgcct 2030521 gcgtcatcat tttgtctttg cttacttatc tctcctataa agaagcgatg tatacgctgg 2030581 tagctgtatt tgtagcggca agattaatcg attttattca ggaaggcgga tacgctgcta 2030641 aaggcgctac gatcatctct tcgaaaaacg acctgattca gaaaaagatt cttgaagaaa 2030701 tggaacgggg cgtcaccatt ttgaaaggac aaggttccta cacaaaagag gatatagatg 2030761 tactttattg tgtggtgccg aaaaatgaat tggtgatgct gaaaagcgtg attaactcca 2030821 ttgatcccca tgcctttgta gcggtaagcg atgttcacga tgtgctcgga gaaggattta 2030881 cgcttgatga aaataaaaat ccgcttccgc gctgacatgt aatagaaaaa aggcggctga 2030941 ccgccgcccc tcatccttat ttagggtagt cccttttttt cagcttgttt ttttccgcct 2031001 tgtactttct gtaaccgaca taggtaagag cagtaatgat gatactgccg gttgtaatga 2031061 tcacccagag taaagacgga tcggcatcat cctcctccac cctgtcaaac acatttttca 2031121 ggtcatgctg aagaagggaa agccgttcaa gcttcgtgct ctctgtcatt tgctgaaatt 2031181 cctcttgctc aataacatct atatgttttc cgactgtttc aagctgatcc tctgatacat 2031241 cgattgtaag actggggtaa atcaagtcat ataaactgat aaattcattc catttttcat 2031301 gaaagcttgt gcttccattc ttttggacat ctcgcttcag ttcagtaaaa gcttccataa 2031361 tcggtttttc cagtgagccc caaagcgggt cagaccgatt gtcaaccgca tccatcagca 2031421 ttctgaactg cgcggctgct ctgagttttt gtgtgtctga tgtatcagct tgctttaaac 2031481 tccgaaccat atcattatag cccaatgtga tttgacgaat ttgggctccc gttagcatgg 2031541 ggtcttgctg ttttttctca gcggatttta atgttttttc aaaatactcc aagacttgaa 2031601 gcgcctcttc atatttcgcc tgtcgggtca tttgaaagac tgtatcggat aaatcattca 2031661 attcctcgag gcttccccgc tctgcagcct tggcatttcc attataaaaa ataagtgcaa 2031721 tcaacaaaca gatcgtcagc tttcgtttca tgcaggtccc tcccactctc tctccttaca 2031781 gaatatgaag aaagggacaa ggatagacca acattgtctt tacatcagct caagcttcgt 2031841 ttgctttttt gagaccacaa gaaagtaagc aagcgcgatt gaaaagatac ttagccaaaa 2031901 tgttccgtat cctatttcag tcatataatc agaaagcata gagtattgcg gcatcatatc 2031961 aaacaagtag tcaatgacat cgttatgcag tgtccagact gcagcaattg caagatgcca 2032021 aaatgaaaaa cgaaaatacg gactgtataa tacgccttga actgccattg caaaatgcga 2032081 agcaattagc atgtagccct cccacggcaa gtcaccagtt actgcaagca caagaaaatt 2032141 catagccacc gcccataggc catactttac gagggtaact agcgcaagcg cctctaaaag 2032201 cggagcattc cgtttcatga gaaaggcaag cagcacaaac agaaagaaaa acgttgctgt 2032261 cggactgtcc ggaacaaaaa tcaggaaacg ggccggtgtc tccaaaagct gcggcaagta 2032321 ccaatagtag ccgtaaaccg ttcccagaaa attaatggct aagacaagaa taagcatcgg 2032381 ccgctgccct aatacatatt gaaaccattt cacatcgaat caactctcag tctgtaaaaa 2032441 taatatgtcc atataaaaaa gctgacgccg ggtcagcttt tgataataaa agtatatcct 2032501 tccatttgac aattcacaat acgttatttt gcggttgttt cagaaataaa ttttgcaagt 2032561 tcttcgagct gcttatcatt tcctttgaac acacccgccg gcattttgcc tttcccttct 2032621 acagcgattt ttttgatttc atccggtttc agcccgctgt caaccaatga aggcccggcc 2032681 gctcctccct gaaggttatc cccatggcaa gaaatacagc cctgttcctt aaaaacctta 2032741 tatccttctg cattggtgtc aatgtcggct tcttttgtaa ttttcccctg ttcttctgcc 2032801 ttggcccagt catgagtagc aactgactgc cacgtcaaaa atacagcagc ggaaatggcc 2032861 agaagcatca taccgacagc gaccggacgc ttccacggcc ttctttctgt ccctctgtct 2032921 aggaatggag ccaaaagcag ggccccaaaa gcgagacctg gcataatcat ggcgccgacc 2032981 actgtaaagc ttccggcggc gtattcatac ttcaacagct ggtataagaa aagaaaatac 2033041 caatccggca gcggaatata accagtatca gtcgggtccg ccatccgctc taaaggcggc 2033101 tgatgcacaa tcgtcaaaac gagaaaaccg atgagaaaga cagctccaac catccattcc 2033161 tttaacaaga aatttggcca gaaagcctct gttttacccg gatactccga ataatccttc 2033221 ggtatattcg gctttttttc agccggtatc cttgagtcgc ctacaaattt catccctttg 2033281 ccccggtgca tgtcatcccc tcccttttat tcgcagatca agagtttaaa gcggtcctga 2033341 aatcccctgc ttccggatca taataaaatg tgcagccatc agcccgaaca atgcggcagg 2033401 aagaaaaaat acatggatcg caaaaaacct agtcagcgtt tgggcgccta caatatccgg 2033461 atgccctgca aggagcgttt taacttgcgt tccgatcaaa ggcgtggctt cggcgatctg 2033521 cagtccgact tttgttgcaa acagagcctt catatcccaa ggaagcaagt agcctgtaaa 2033581 gccaagaccg agcataacaa aaaagatcag cacaccgaca atccagttca gctcgcgcgg 2033641 ttttttatac gcgccttgga aaaagaccct cagcgtatgt aaaaacatca tcacaatgac 2033701 caggctcgca ccccagtggt gcatccccct gacaatctgg ccgaatgcca cttcattttg 2033761 caaataatat accgattccc aggcattttt gatatcaggc acataataca tcgttaaaaa 2033821 cattccagat aatacttgga taacggttac aaaaaacgtc agtcccccaa agcaatacac 2033881 aaacgcagag aaatgatggg cgggattcac atgttccggt acttcgtgat cggcaatatc 2033941 cctccacatc ggtgtaatat caagccgctc gtctacccag tcataaattt tgttcagcat 2034001 gtcacccttc ccccttaggc tttgcttttc caagatacag gaagccgtct tttacttctt 2034061 gctcataatg atcaagaggc gcaagcggcg gcgtgccagg gacattggtg ccgtcctttt 2034121 catagagtcc gtaatggcat ggacaaaaga atttattcgg gtttttagga tcactattcc 2034181 agttcaccgt acaccctaaa tgcttacaaa ttggcgaaag tgctacaatt tcatccccgt 2034241 ttttgaagac ccaggctgat cttgactctt ctgactcata ccaggcatcg acttgattaa 2034301 ttttaaaatc aaagcgctgc ggctcttttg tcaactcatc aacgctgaca acctgaacca 2034361 tatcctgctt ccctgtcgat tttaataccg ggtcgagtgc gaagcgaacc ataggcatga 2034421 gcatactagc cgccataaaa cctcctacgc ctgtgagcgt ataattcaaa aattgacgtc 2034481 tggatatatc atgttttccg cccatctctt ctcccccctc taagtcaccc ctgcaaactg 2034541 actaaaatag aaaatattgc aataactcta gacaccctca taatatatga atctctcagc 2034601 aaggtcaata tagccaaaat attgtttata aggaaatgta agtgttttta taaagtgctc 2034661 cataactgta acaaaacgtt caaaatttca gcagtgcgtt catccaatat ttttcttttt 2034721 aaagagtcat ttaaatgctc taatggaaca gacgatgtaa caatcatttt gcctaacgca 2034781 tcctcagctc tccaactttc gtcagatgtg agcaggacaa catgcggaaa ttccgttatc 2034841 agctcttccc gcaaatcctt aagcccttga acggttattt catttctatc aacatatgta 2034901 taaggcggaa gtaaatatac ccgtcccttt aactgccttt caagttcttc tgagagaagc 2034961 tgcgtaaact cgcctttctc cgccgccatt ttaaaatggt tattaaccct tatgttaatt 2035021 aatggtatga cagcggtatc aatgtaatcc ttagcttgta aatagtcctt ggcatcagtg 2035081 attctccacc tcatcgttct ccccctttac ggcaacaagc cttgcaattc actgcaaggc 2035141 tggtcatatt atgtgagctg atttaattgg cgcgataatt gttcaaatgc ctctttatca 2035201 tgacgatcta acgcgtcgtc aatgtctttt aataattttt ctctttggaa tgtggaaata 2035261 gcgtgctcta aaatctgttc cgccaatccc tgatcttttt tattctcaaa aaggtttttc 2035321 ggaatatgcg ggttggactc cagcaccgcc gcatattcag gtgagctgta agccgaacgg 2035381 aaattaagct ggataaacaa atcctgctgt ttatttaatc taatatcatg aaaagatttt 2035441 tccgcgtcgg tagtcatgac attctcttta tagaaccgga acggaacttc ttcaacacaa 2035501 tgtgttgaca ttataatgcc tctcgggcaa aattcagcct gctccacaaa atgaaccttc 2035561 tccatgagag aatcatggct cattaagtag ttcaagatcc aaacgcactc tcggcgcttt 2035621 aactgataat ggtttaaaaa ccaacggata aaatcttttt tctcattgac agaaacaggg 2035681 gtctgcatgt aattccctcc tctatcgttc gtataatcta tatacttata tgttccacat 2035741 gaatggttaa tattcctgct tatctagaaa attcatcctc gattcgcaaa atcgtttctt 2035801 caagctcttc attggctccg tccatttcaa gaaccttttt caaaagcggc agcgcttctt 2035861 tttgaagacc ttcttctaat aggaagcttg cgtattcata taagaaatct ctatcctccc 2035921 ggtaatgaag ataggcagcc tcaaaggatt gttttgcttc ctcgtattgc tctaattcag 2035981 tatatgcgct tgcaagatac caattgtatt taggatcttc ttcaccgtag cttcgaacct 2036041 cttgaataag atcaatgatc tgatcataat cctcttcttt gtgatacacg gcaagaagtg 2036101 tatgaagcgc ctcgacaaag cccggatcaa gcgcaagcgc ctcctgaagc agcttcttcc 2036161 cctcttctga cttcccgatt ttcaaggcca ttttggcggc ataaaggaaa agttctttgt 2036221 tatattcatc atatctgatc ccctcttttg ccgtttttaa tgcctcttca tacattcctt 2036281 cagcttcata gcttttcgag agcggcatat aaagtgaagt ataagatgga tcaagctcct 2036341 ttaaatcaga cagctgctta atagctgttt tcacaagccc cgcctgtaag gctgtaaaac 2036401 catagccgaa aatcgtatta ggatcaggat tctcatcgac agctttctca taccatggaa 2036461 tggcatcctc aaattcacct gaggcactta acgattctgc cagtctttga tggacattaa 2036521 cgcccccgat ctcactctgc tcctcagccg ttgttttaaa atattgaacc gcttttgcat 2036581 aggctccctg agcaaagtaa agttctccca gtgcaaaatc aataacaggt tcattgtcca 2036641 gaatggactt tgcctggaaa agcttttgtt cactgacttc gaataacccc tgcatctgat 2036701 aaagatccgc cataagcagc aaactttccg gatatgatgg atctgtttcc ggaatagtct 2036761 ccagcacagc gagggctttt tcttcttcgt caatatctat taaaagttca gcgtagaaat 2036821 tcgtcagttc tgtttcattt ggatataaat catgtagatc actaatcagt gaaatggctt 2036881 tttctacatc gccccactcg taataaagct gggctgcaat ggctttatct tcatcatgca 2036941 gctgtttttc agccttcgag agcgtgttga ggcctttttc tgtttcacct gcttcaacta 2037001 attttatggc ttcttgaatc aatgtattca aatcggaccg gtcctttctt ttcctataca 2037061 acatcaacca tacaaaaaaa gctttatttg ttcgggttaa tcttatcata attcagacga 2037121 atgcccccgg caaataagat gcttctgtac ggaagggaat tattgagtct tattagttta 2037181 ccaaaagatc ttgagataga aaatgaaaaa aggaagatcg ccctctgtac agtaaagcag 2037241 ctctttgacc tgccggcttg taagtaaagc acatcccccc ttttcgtttt tctatccgtt 2037301 ctataagaca agctatgttt tttcgcctcg aattatgatc tgcataaaaa atcctgaagt 2037361 aaaacttcag gattttttcg aaagcttatt taaatgctcg aagaaggttg gataagaaac 2037421 gtgaatggca tccgtgtgct cgatttcaat cggctcctcc gttatacagg aagcaatacc 2037481 aagcatcatt ccgattcgat gatctccgtg gctggacact gcagcgccgc ctttcaacgt 2037541 ttgtttgcca taaaccttca ttccatctgc tgtcggttca atttcagcac ccagcttgcg 2037601 aagctcagaa acaacagtat caatacggtt tgtttctttc acttttagct ctgccgcgtc 2037661 cttaataacg gtggttcctt ccgcctgagt cgcaagaagc gcgatgatag ggatctcatc 2037721 aattaaacgc ggaatgatat ctcctccgat ttcaactgcc tttagagatg acgtttctat 2037781 aatcaaatct ccataaggct ctgcaccgct atcagcagat ggtttgattt caagttttgc 2037841 ccccatgttt tgaaggacat caataatacc tgtccgagtc ggatttaaac ctacgttttt 2037901 caatacaatt ctgctgtttg gaaccatcgc gccagcagca aggaaaaacg cggctgaaga 2037961 aatgtctcca ggaacaaaaa tatcagcagc tgtcagtttc tggccaccag caatggaaac 2038021 actcgtttga tcttcagaaa gcttaacgcc aaaagcagaa agcatccgct cagtgtggtc 2038081 ccgagattta tggggctctg ttacagttgt tgtgccctca gcctgtaatc cggccagcaa 2038141 aacagcagat ttaatttgcg cgcttgcaac aggtgataca taatcaattc cttttaatga 2038201 agcgccgctc actgacagcg gtgtaaactc tccgccggct ctgccgtcga ttttagcccc 2038261 catttttttc aaaggctcag tcacacgctt cattgggcgt ttcgcaatgc tctcatctcc 2038321 ggctaccgcg ctgtaaaaag gacggcccgc caatattccg agcatcaggc gaatcgttgt 2038381 acctgaattt ccgacatcta aaaggctttc tggctctttc agggcatcga ttccttttcc 2038441 gtgaatcacg acatcgctgc tgctttgctc aatgtgaaca cccatttttc taaagcaatc 2038501 gatcgtgctc agacaatctg ctcccggcag aaagttttta actgttgttg tgcctgccgc 2038561 tagcgcgcca aacataacag agcggtgaga aatggattta tcaccgggaa tatgtatttc 2038621 tccatgtaag gtctgcacct tatctcgttt cattttttcc acctcaatca gcataaaaag 2038681 tttcatattc cgcccgggct tcaatgcatt gttctgccct tttgcggtcg tcatcagact 2038741 gaaaactgat ccttaaaatc ccgttaatat cctctcgtgt ttcgataatg cggatattcg 2038801 tgatactgat gcgctccgca gctaagatcg ctgttatctc ggatattaca cccggatgat 2038861 cgggtacatc cacatataaa tcataaaatg caggtatcgc tcccttctgc cgaagcggca 2038921 gcccgtcgcg ataatccttg gctgttttaa aataacgaaa tagattttcc gcatcttctt 2038981 gttctacata tgtacggatc ttgtcaattt cacgaatcca ctcatcaaaa cggtctaaga 2039041 ttttatcttt attatgtaat aaaatatccc gccacattgc cgggctgctt gatgcaatcc 2039101 ttgtaatatc tctgaacccg ccggcagcaa aacgcttaac aagcggatac aggttttccg 2039161 aatgatgggt ttggtgaaca aggctagctg ctacaatatg cggaaaatga ctgattacgc 2039221 ttgtaacgcc atcatgctcc tctggcgaca tttccacaaa atgggcattc gtccccttca 2039281 gcaggttttt taactgttcc acagcttgtt tgtccgtttt ctggcctggc gttaaaatat 2039341 aaaatgcatt ttcaaacagg aactccttcg cagcggccac tcctgattta tgtgaacccg 2039401 ccatcggatg ccctccgaca aattgatagc ggctaggcag cacttgatca gcgtaatcaa 2039461 ccactttttg ctttgtgctt cctacatccg taatcaaaag ctcatgttca attcctgaat 2039521 gagccagctc ttcaagcata accagtgttt gttcaacagg tgtcgcaatg attactgtag 2039581 ctgcctcttt cacaccgcta ataaacgaat cagcacgatc gtctatcacg cctaatttta 2039641 atgccgctac cgcctgttca tcagagatgt cgattccgat aatccgtttg ccgggatgat 2039701 tttttttgat ggctagggca atcgaaccgc ctatcaatcc gagaccggcg agcaatattg 2039761 tatctttcat ttgattcata cgtcatcacc tggtttatag actaaagagg tgatatttga 2039821 tcacctctta taaaatttca gctaaaatgg caagtatttc ttcattttgc tcttttgttc 2039881 cgatcgtaat ccggagtgat gtcgggaaac ctaatgcgtt tcctgaccgg acgatatagc 2039941 ctttttccag cagagcctga aacagttcat cagcaggacg tttaaagtca attaacacaa 2040001 aatttgtctg tgaagggtag cactttaaac catgagtttt cgcaaaatca taatactgct 2040061 gaaggcctgc attattttgc tcgacacagg aagcaataaa cgcttgatca tcaagtgctg 2040121 caatcgccgc agcctggccc agacggctgg tattaaacgg ctctctcgcc ggctcaatct 2040181 ggcgaatcag gttctcgtca gcaattccgt atccgactct gagcgctgcc agaccgtatg 2040241 cctttgaaaa tgtgcgcaaa atcatcaaat tggaatactt gcttaagagc ggcacggttt 2040301 ccgggtaatc ctctgctgtt acatattcat aatatgcttc gtcaagaacg acaaggacac 2040361 gagaaggaac gcgctccaga aatgcgagta attctccttc agatgtataa gtgccagtcg 2040421 gattattcgg gctgcatatc caaacgactt gtgtctgttc gtcgatggct tctaacatgg 2040481 cgtctaaatc atgtgagccg tcgggacgaa gtgcaatttc acgtacttca gcaccttcaa 2040541 taaccgcatt atgtttatat tgcggaaaag tgggggcagc agtaaccgtg tttgttttat 2040601 cgtttaaaaa tgcccggcag atgatctgta tgatttcatc agaaccgttg ccgaaaataa 2040661 gtgatgtttc gctgacattg aggtgcttac tgagccttgt ccgcaaagcg gcgctatacc 2040721 cgtccgggta aagggctagc tgttgaatct catgatgaag cgcctctttt gcagcctctg 2040781 aacagccgta aggattctcg tttgaagcaa gcttcacaac tttatccaag ccatattctg 2040841 atttcactgc ttcaatcggc tttccaggct gataaggctt cagctgtttt aaatgttctt 2040901 tgatacgcaa atcagtcacc tcattttaaa ctgtacaagc cgctaaacgc cattgcataa 2040961 tcctcaaact cctgcagcgc ctgatttctc gtttcagcgc tgatgagccg gtcctttaat 2041021 tcttctattt ttctgacgag cgcacttccc actacgacac cgtcactaat ttcattcatc 2041081 tttatgacct gttcacggtt tgatataccg aaccctacag caaccggaac agtgctgaga 2041141 ttcttcacag tacgaatgaa cgggtacacg gatgaattga actcattgcg gacaccggtc 2041201 acacccagag aagatacaca gtagacgaac ccctcggctt gttcaataat ggttttcaaa 2041261 cggctttcgc ttgtcggcgc aactaaagaa atatacgtca cctcatggct tttacattcc 2041321 tcttgaaggc tgttgctttc ttctaatggc agatccggaa caagcagacc gtcaatatga 2041381 ttttcccgca gtaaagcgaa aaagtattct ttgttcaatt gtaacacagg attataatac 2041441 gtaaagagga taatcggaat attcactccg ttttttttca tttctccgcc taattcgatt 2041501 gcctttacga tattcattcc ttgatcaagc gcccgctttg aagcccgctg gatcaccgga 2041561 ccgtctgcaa gcgggtcaga gtatgcaaca ccaagctcca atgctgtggc gcctgctttt 2041621 tggagtgact tcgccagttc aatcgaaacc tcaggaactg gatcgcccgc cgtaataaac 2041681 gggataaaca atttttctga tggttgaaga tccaatttaa acatgggctt tcacctcttc 2041741 ttccaataca ttcattaatg tgttgacatc cttgtctccc cggcctgata aacagacgag 2041801 aatgagttga ccgcgatcca ttcctttggc gagtttgaat gctttcgcta acgcatgggc 2041861 agattcgatt gccggcaaaa tcccctcttt ttctgacaaa agctttaatg catccaccgc 2041921 ttcttcatcg gttatactgt cataagtgac acggccgctt ttatgcaaat atgcatgctc 2041981 cggaccgatt ccaggatagt cgagaccggc tgaaatagag tagggctcaa taatttgccc 2042041 gaactcatcc tgaatgagat aagtcaatga accgtgaata acccctacgg ttcctttcga 2042101 aatagtggcg gcatgaagag gtgtatcaat tccttttcct gctgcttcag cgccgatcag 2042161 ttcaacatct tcatttaaaa atgcctgaaa catacccatc gcattgcttc ctccgcctac 2042221 acatgccact actttatcag gcatagtgcc ttcaatacgt ttcaactgat ccttcgcttc 2042281 ctctccgatc attttttgaa attcacggac cacttgcgga taaggatgcg ggccgacaac 2042341 tgatccaatc atataaaagt gatcctcaca atgctgaacc cagtaccgga tcgcctcatt 2042401 tgtggcatcc ttcaatgttc cgtttccgct tgttacaggc actacctccg ctccaagaag 2042461 cttcatgcgg aaaacgttca gagactggcg ggcaacatcc tcttcaccca taaacacagt 2042521 acaggaaaag ccgaatttgg ctgcaactgt tgcagcggca acaccatgct ggccggcacc 2042581 ggtttcagca atgattttcg ttttgcccat ttttttagca agcagcgctt gacctagcgc 2042641 attattgatt ttatgagaac ctgtatggtt taaatcttct cgtttcaaat agattttcgc 2042701 gccgcctaag tattcagtga ctcgatcagc gtatgttaat gcagtcgggc gtccggaata 2042761 gtcctttaac agcttataat actcttcacg aaaagcggga tcatccttga tttgtttaaa 2042821 tgctgtttgt atttcatcta acggctgcat gagtgtttcc ggaacaaact ttccgccaaa 2042881 atcaccgtat ctgcctattt cattcggata tggatacata tcggttcatc ctttcttcta 2042941 aaagcctcat cagattctga tctttttgtc cgtttttttc aattccgctg gcaaggtcaa 2043001 ttccttctgg ctgccatttc aataggcgtg tgatgctatc cggattcacg ccgccagcga 2043061 taaagcagcg tttaccaata gccgcctgct gatattccgg cacacattcc caagaaaatg 2043121 caacaccagt tccgcctcta gaccctttta cagatgaatc aatcacaaag ccgtcaacat 2043181 tatctttaaa gcgggctatt tcttgagttg tgttatcttg atggtgaagc gccttccata 2043241 tttcacagcc tgtcagcttg cgaagagcag cagcatccgc cggtttttca tcaccgtgaa 2043301 gctgaatgac gtcgagcttc aagctcttgg caatacgtga catcgtctct attgattcat 2043361 taacaaaaac acctgcaacc tgtttttcga cacgaacttg gttcagccat tttttcacat 2043421 cttccggaga tacttttcgt ttgctttcag caaaaataaa tcctaggtaa tcagcctgtg 2043481 attccgccgc aagctgcaaa tcctttagtg accgaatacc gcaatatttt aatgccggtt 2043541 tcttcacaac ctcactccct aaacaaagca tggattgctt tacgctgaga agtttgtctc 2043601 atcaatgatt caccgataag tacagctcgt gctccatgtt ctttgacaaa tgttaaatgt 2043661 tctaaagaac cgattccgct ttcgctgaca agcagtgatt ctttcggagc aagagatgcg 2043721 atttgttctg tctgcatgat agaggtttca aaagttttta ggtttcggtt gtttatgccg 2043781 agaatatcag gcgtgaatac tttcaatatt tgttctagcg ttgttgcatc atgaacctcc 2043841 actaacacgt ccatctcctt ttcacctgct tcaagatata attcatgaag gtgtaaggga 2043901 tcaagcactt cgccgattaa caatatggca tccgctccga ttcttcttga ttcctccact 2043961 tgaagagaat caataataaa atcttttctg agtacaggta tcgaaacagc gcgctttacg 2044021 tctgataaat agctgttttc cccttgaaaa aacggggtgt ctgttaaaac ggaaagcgca 2044081 tctgctttcg cagtttcata gtcttttgca atccgcacag gtacaaaatt ctctttaata 2044141 agcccttttg acggcgacgc tttcttcact tcagcaatca acccgataaa ccgattcagg 2044201 cttgccagcg cctctttaaa tgaacgtttt tcgaaaggct gctctaccgg cagaaccagt 2044261 gttttcactt cttctttctt ttgtttgatg attttttcaa gcatagatct cttcctcttt 2044321 ctgctttagt cgttcaagct gcgcggcagc gcctccgctt gtaatcgtct ctaacgccag 2044381 ctccgttcct tccttcagtg aggcggtaat tcccgccgtg taaatcgcag cacccgcatt 2044441 aaaagccgta atagataaag cggaactgct gcttttattt tcaaaaatat tctgaatgag 2044501 ataagcgctc tctttcggag actgcacctg taaatcttca agtctgccat ttgtgaaacc 2044561 gaaatcttcg ggtgaaacgg tatactcccg gcgctctccg tcctttaatt caatcacgtc 2044621 ggtcggtgct gtaattgaaa gctcatctaa accgtcacgg cttgatacaa acataacgtg 2044681 cttcggctga aacgtctcca gtgcgcttgc catcagtcca gctttttcaa cagaatagac 2044741 cccaatcacc tgacgcttcg cctgtaaagg attgctgagc ggcccaagca gattaaatac 2044801 cgttctgaaa cctagctctt ttctagtacc tgctacatgt ttcatagacg aatggtaaag 2044861 cggcgcaaaa agaaatccca tgttgtttgt ttcaatgctg cttttgacct tttcgggagt 2044921 ggtttgaata gaaacctcta gctcctctaa aacatcagcg cttccgcttt tagaagagac 2044981 agagcgattg ccatgcttag cgattttcgc accagctgcc gaggcaacaa ttgccgaggc 2045041 cgttgagata ttaaaagtgg aaataccgtc tccccctgtt ccgcatgtat caacaatatc 2045101 aggaagtcca tcgactgtaa gagcgtgtgc ccgcattgcc ttcacaaaac ccgcaagctc 2045161 ttctggcgtc tccccccgat gagcaagaat tgacaatatc ccccccattt cagaaggagt 2045221 catttccgct gccatcatca tattcatcag cgtttcagcc tcaccggcag taagggtttt 2045281 tccgtcaacg cacaattgta gaaatctgtt catcagcttt atcctccttg ctatgaaaca 2045341 tgtcttctgc aatatgaatc gttttcagca gcgcaccggc tttattacag ctttcttcgt 2045401 attcggcttc cggaacagaa tcagcaacaa tgccagcacc tgcctgtatc gatgcaacac 2045461 cgttctttac actcatcgtg cgaatcgtaa tacaagagtc gatattcccg tcaaacccaa 2045521 tgtaggcaat acaccctccg tatgtctctc tcggtgttgg ctcgagttct tgcaaaagct 2045581 gcatggcacg gattttgggt gcgcctgtta aagtccccgc cgggaaagca gacatcagtg 2045641 catcgacagg atgaacccct tttttcaatc ggcctgtaac caccgagata atgtgcatga 2045701 catgtgaaaa ggaaacaatt tttgtgaact ccggcacaga aacagaacca tactctgcta 2045761 ctctgccgat atcgtttcgg gcaagatcaa cgagcatgta atgctccgct ttttcttttt 2045821 catccttcat gagctcaacc ttcagtctct catcttcagc tttgtctgca ccgcgttttc 2045881 tcgtaccggc aatcggatgg atttctaagt gcccgtcttg aacgtgtatt aaccgttccg 2045941 gagagctgcc gactatttct ctgtctagca gtttcatata atacatatac ggcgaaggat 2046001 tgacgatcct aagcactcgg tataactcaa aagcatctgc ttttatcggc acctcaaatt 2046061 tttgtgataa aacaccctgg aagatatcgc ctgcttttat atagcttttg attttttcta 2046121 catcagccat aaaagccgat ttttcataat tagaagatac tgtctcaaag ctgggtgtct 2046181 tgtatgaatc agcagaaaga aacagctctt ttatgttttt ttggtccatc attttttcaa 2046241 tgagattttg aagctccaga tgattttgat ggaatacatc cattttttcg ttttttgttt 2046301 cctctccagt gagccttgca tattggataa agtggacgtt tttggtttca tgatcatacg 2046361 caattaatgt ccggcaaaca aacagcatac acttttccat gtctgtttct ttggtatgcg 2046421 aaggaacaga aggctcaatc agcgggatca tatcatagct taagtacccg acagctccgc 2046481 cgacaaaagg aatgccaagc tcaggtgttt tgattttgta tgtggtattc atccagttca 2046541 gcacttcttt tagttcattt cctgtgtaaa gagatttgct gtcctgatca gcggccgaaa 2046601 aacggccctg ctcttcttta attgtgagaa atggattcag gccgataaac gaatatctgg 2046661 accaagtgga tgtatcgtcc ttgctttcaa gaagatacgt aatctccctg tcaagcttct 2046721 ctatcatttg aatgggtgtc agtgtatcga ctgtgaaggt ctccacaatc ggtatcgtgt 2046781 ggtgggacaa gctgtcctct aaaaatgcgg aaatgtttga ttggaaattc attgctctca 2046841 ctccttatgg caaggagaat gagaagatgg catgagagga taaaatacta tataacaaat 2046901 aaacccaaaa gaaagacttc ttttgggtag aataaacata atgtctcagc tcaactaaac 2046961 tcattctctg ctaccctatt ctctaactca actcattcta attgctttat acacactctt 2047021 gtgtatttct aagctgttct tatcgtatta caattcagta ttttttgtca atgataaatc 2047081 gggcctcaat acgacaactt tttctaaata tacatgtctg atctgatcct gagggacatc 2047141 tgtctggacc gtcatcatga ctcttatgca ctttttcaga ccgcctgtta cgtccatttc 2047201 ctgcatacat gttaccggta catactgcca tcctgaaagc tcgcgaacag cttttgccgg 2047261 gaaaacagcg tgcaaatcag gtgtagccga cagaagcatt tgaacaacat cttccggttt 2047321 tgtatgattt tcttctatga ttttctctaa cagctgttta gttttttgta aaatttcttc 2047381 ttcagtatcc cgttcaactg tagttgctcc gcgaattccg cgaatcatca tgatgtctcc 2047441 tccaatcgcc atttgttcag ccagctctca agttcatttc tggaaaatgt atgatcagca 2047501 actttcccta attcgttgag cacaataaac tgaatcttcc cgccacgggt tttcttatca 2047561 ttcatcatac ggttcaagag aaccgaagtt tccgtctctt ttctgatttg acttggataa 2047621 cccaggcttt ttagccagct gaccaaacgt tttctgtcca tttcacagcc tacagtcttt 2047681 tcgcttatat ataaagcaaa ctgcattccg agggctacgg catcaccgtg agtgatctgc 2047741 ccatatccat attccgcctc aacggcatgg ccgagcgtat gcccaaagtt taagtaagct 2047801 cttatcccct cttctttttc atcctgctga acgacagacg ctttaattga aatgccttta 2047861 aaaatcatgt cattcagctg atcattagtg atatcacgca gtgagtggat attcagcagc 2047921 tcctccagaa acgctctgtc atagataaaa gcgtgtttaa tcacttctgc cattccggac 2047981 ctaagctctt tttcaggcag agaacgcagg aaatctgtat catagagcac ggctttcggc 2048041 tgataaaacg caccgattag attttttcca agcggatggt tcacggctac ttttcctccg 2048101 actgcgctgt catgcgccaa gagcgtcgta ggcatttgga tgaaatcaat gccgcgcata 2048161 aaagtggcag ccacaaaacc ggcaagatcc cctacaacac cgccaccgaa tgcgatgatg 2048221 catgaggagc gatccatatg aaaacgaatc gcttcactct gcaattttgt gtacatgtcc 2048281 atggattttg cctgctctcc actcggtacc gtcacttttt tcacaggcca tttttcttgc 2048341 agcaaatgga gcatttcatc accatacagg cggtccactt cttcatccgt gacaaacata 2048401 atccttgtta aaggcctgtt taaagaggtt aatagttcgc aagccttttt tctgatacct 2048461 tgtccgataa aaacaggata tgacgaggaa gcagtttgaa catgcagtgt cttcattaaa 2048521 attccctcga cagttttctc atattctcca cattttctct aatgcggtca atttgatcta 2048581 atccgaattg ttcaacgact gcgttcgcaa tttcccaagc gacagccgct tcagcgacta 2048641 cacttgccgc aggaacagca cagctgtctg aacgttcaat gctggcagaa aacggttctt 2048701 tcgtttcaat atcgacactt ttcagcggtt tatacaaagt cggaatcggc ttcatgactc 2048761 cgcggacaac aatcggcatc cctgtcgtca tgccgccttc cagtccgcca agtctgttag 2048821 tagcacgggt gtatcctttt tcctcgtccc aaatgatctc gtcatggact tcgcttccat 2048881 ttcgccctgc tgcctcaaat ccgatgccga attccacacc tttaaatgcg ttaattgaca 2048941 gaacagcggc agcaagcttg ctatccagct tgcggtcata atggacatag ctgcccacgc 2049001 ctaccggcat tccctcgaca atgacttcta ctattccgcc gatggaatct ccgtttgcct 2049061 ttgcttcatc aatggcagcc atcatttttt tgcctgcctc ttcatcgtag catctgacag 2049121 gagactcttc cgttacacgc tgcaagtctt caattgacgt atactctgtt ttttcagctt 2049181 taacagcgcc aatttgcaac acgtggcccg ccaccttaat gccaagctca gaaagaatct 2049241 ttttagctac agcccctgcc gccactctga cagttgtttc ccttgctgaa gaacgctcaa 2049301 gcacatttct catatcacga tgattatatt taattgcacc gtttaagtca gcgtgcccag 2049361 gtctcggtct ggaaatctgg cgcttcattt ccttttcttc atcttctgta atcggagcgg 2049421 cgcccatgat ttttgtccaa tgcttccaat cgttattttc aactacgaga gcaattggcg 2049481 aaccgagtgt acgtgcatgg cgcaccccgc tcataatttt ggcctggtct ttttcgatct 2049541 gcatgcggcg gccgcggccg tgtccttttt ggcgtctggc aagctcaaaa ttgatatctt 2049601 cctccgttat gtaaagcccg gcaggtacac cctcaataat ggttgtcagt tgggggccgt 2049661 gtgattctcc ggctgttaaa tatctcatga cttcttctcc cttcatcgca ttaacgcttt 2049721 taagtaagac tactataaca tatttttcag caaaaagtca gtctatcttt tttgataaaa 2049781 gaatgtatcg gctgggacta ggccaaattt ctcgggattg aagatttgct cggtgctgcc 2049841 gacaaaaaga actccattct tcttcaagct atgtgccatt tttaaataca gctcttcctt 2049901 cgcgctttct gtaaaataaa taaatacatt gcggcacacg attaagtcaa agtcttgttc 2049961 ataacgatcc gccagcaaat tgtgcttttt gaatgtaata ttctttttga tttccgtttt 2050021 cacttcataa cttctatttg cgttttgcgt aaaataacga tctttcacag atagcggcac 2050081 ttcctgtaaa gaccgctcct gataaacgcc ttttttcgct ttttccaatg ctttttcatc 2050141 aatatccgtc gctaaaatct gatagcccgg aagacctttt tgctggtcca aaagcatggc 2050201 aagcgtgtat ggctcctccc ccgttgagca ggcggcactc caaattttta aaggcctaga 2050261 ggtcttgatt aacggcagaa ttgcagtctc aagaacttcc catcttttat aattacgata 2050321 aaattctgaa acattgatcg tcattctgtc caatgtttca tttaagagag cttgatcctt 2050381 ttccaatgcc gcagcaaagt ccttaaagct ttggaacccc tttttctcat aaagtgacgt 2050441 tagccttctc ttcatttgtg cttctttata tagtgttaaa tcgactccgg ttaattgttt 2050501 ccatttcgtt gtaaatacgc tgtatgtatc catctctact ctcccagtct cgctgtcttt 2050561 ttgtcctagt atagcttgtt ttatcaggaa attgtattgt ttcaataaaa aaatcagctt 2050621 ttcagctgat tttagatcgt tgggaaaggc agaggtctga tgcacactgc cattcaaccc 2050681 tttattcact ttaatgtaaa cctttacaaa acagaacaaa aaccggcggc gttatatgtt 2050741 gccggctctg ttgcttattt tcacaatgat taatagatcc agcctgccat aagctgctga 2050801 tatgatacta attcttcatt cttaaagaaa atgttaatct cgcgttctgc actttcgaga 2050861 gaatcagagc cgtggatgat gttttttccg acaaacatgc cataatcccc acgaatcgta 2050921 ccaggtaaag cttctttagg gtttgttttc ccgatcagct gtctcgtcac ttcaatgaca 2050981 ttttcgcctt cccacaccat tgcgaataca ggtcctgaag taataaactc aacgagctct 2051041 ccgaagaaag gcttaccttg atgttcggcg tagtgtttct cagccatttg ttcagtcact 2051101 ctcattaact tggcgccagc taattgtaag cccttacgtt cgaatctaga taaaatgtcc 2051161 ccaatgagct gacgttggac accgtctggt ttcaccatga taaaagtctt ttccatcata 2051221 ttctccaccc catcattatg tatgtatagg ctttcacact gcacaccgaa atcgtaacat 2051281 ctttctgata attaatcaat ccggggcgga gaaatttctt aatatctaca aaaattaaaa 2051341 ttttctttta ccgatatatt ttgcgatggc tgcaagagac gagcgtgcgc gccctcgagg 2051401 aagcgtgttt aatttctgaa aagctttctg cagatacatt tcgcttactg ccatagatgc 2051461 ttcaattgca tctgtttttt tgatttcttc aatgattggt tcaagctgtt cctgcgttgt 2051521 ctcactgtta atcaatttaa gctggttttt taatgcagga tttttcaggg catacagcac 2051581 tggcaatgtg acgtttcctt gaagcaaatc tcctcctacg ggtttaccca gctcttcctc 2051641 agttgaagta aaatcaagaa tatcatcaat aatctgataa gacatgccga cgtaataccc 2051701 aaaccagtac aatgccttat gaatcttctc atcagctcca gacgcaatgg caccaagctg 2051761 gcagctgacc gcgatcaaga gagctgtttt tcttttgata cggcggagat acgttctgag 2051821 attttgttcc atgttgtatt tgtctttgat ctgctcaatt tcccctagac aaacttcaac 2051881 gatcgtctgt gacaaaatcc tatgggcttt cggttcgtta attctcgtca tcatttcaag 2051941 agatcccgca agcatataat cgcctgtgta catcgcaata cgattgtccc actttgcttt 2052001 gattgtcggt tttcctcggc gaagctctgc atcatcaatg acatcatcat gaaccaaaga 2052061 tgccatgtga atcatttcca gagtgacggc gacatattta atcttattaa tatcataatc 2052121 gccaaacatg ccagaaagca gcacgaaaac aggccgaata cgtttccctc cggcctgcag 2052181 caggtgaaga cctgcctcgc ttaaaagcgg gtaatcggaa cgtacggttt gttcaagttc 2052241 tctttcgatt acatcaatat cgtcatttaa aaaagagtag gccattttaa atttcatatc 2052301 attcacccaa acatctgtgt tttcatttcc atccgatatg cgtggcagcg actccgccag 2052361 taaacgaatg atatttaaca tttttcaggc ccgcctcttc aaacaggcct gccagttcct 2052421 tcattccagg gaaatctctg gctgattctt gaagccaaga atattcttta tagctcttcg 2052481 caaacagttt cccgaaaaac ggcataatat acttaaagta cataaagtaa gcctgtctga 2052541 atccgaacat ttccggctgg gacgtttcca gacataccac ctgcccgccc ggcttcacta 2052601 cacgtctcat ctctttcagt acagtcaagt aatcagggac attgcggagt ccgaagccaa 2052661 tggtgacata atcaaatgta tcatcatcaa aaggaagctc catcgcattt ccgtgcagca 2052721 gttcaatttg gctgaatccg ccgtctttta ctttctgctc gccgacactc agcatatttt 2052781 cactgaaatc caagcccttg atctcgccgc ttttgcctgc cgcttttgca agagcgatcg 2052841 tccagtcagc cgttccgcag cagacatcaa gtgcttttgc gccttccttt acattcatga 2052901 tgcgcatcgt tttgtcgcgc cattttttat gctgctgaaa actgatgaca gagttcattt 2052961 ggtcataatt tttatatatt ttttcaaata ctccgtgtac gcgctgttct tttgagtcct 2053021 gcataatggt ttacccttct tccactttct gatgataggt ttgatcttgg ctgattgtct 2053081 tcagacggtt tattaaaatg ttctgaatag gtgaatttag aggcagaagt gactcaatgc 2053141 tgtttttcgc ttttttaaaa caatcttcta atatctcttc ttttgttttt cccagctgta 2053201 taaaactgcc gatcacatcc agaaatgcat catttccgtt cataagccgc ttaaatacaa 2053261 aaaaatcact cgacagcttt ttccagcgcg ggaggttgaa gtgttccgcc acacgatgga 2053321 ataaagctga ttcaacgatg ccgacacttt cgaaaaaatc gttttcgtcc ttgaaagaac 2053381 ggtcatacag acgaatttta tgttcgttga tttctttaat ggctgtagca agcgtccgaa 2053441 tcatgtagat atccttcatt tcagatagta aagagtagta cagcccgctg aaataatcgc 2053501 ccgcgagaac agtcaattgg cggtttttgt tttcgtctcg ttttatgact ctagctgtcg 2053561 tcacttcatc atgggtatca agggcgcttt gtacaagcat cgctgttaca atataatttt 2053621 ctctgtcgtt gttttttatg tcggcttctt caaataaagc atgaaaaaga agaagcttat 2053681 cctcatcaat tttcggcgca gaaatatgct tcgctaaata aggatgagac agcttttgtt 2053741 ttaatttcgt gttcagattg gctaaagttc cgtagatgtc ttgcaaaaat atcacccttg 2053801 tccccaaatt cacatttatt tcttaatcta tgtatgagtt ttatcttttc attcgcttac 2053861 gcaggtatca ttatagcata aaaaaaagaa attggctgta tcctcccgct gtttgcgagc 2053921 atttgctttt aacagcgggg acagccagct tatttttttt cgcttttcat ttctccgtac 2053981 gcggtttgaa tcagtgcctc tcctctgact ttaatggcag aagtatgctc tgtaaactga 2054041 gcgatgatca cttctccctt gtcgagtttt tcggaatggt gaaactttgt gtctgttcct 2054101 cttgtcaggc cgatcacatt cactccgtcc tcaacggctt taatgacgac aaaatcactt 2054161 gaatgctttt ggttcattta tagcaccctc tatctttatt agtcctggcg tttaatatgt 2054221 tccaatactt ctgcacgggc agcggcatca tctttaaaaa cgcctctgac tgctgaagtc 2054281 acagttttcg cacccggttt tcttacaccg cgcatcgtca tgcacatgtg ttccgcttca 2054341 accactacca ttacgccatg cggatcaagc gtttctacga tgctttctgc aattgtagaa 2054401 gtgatgcgtt cctgaagctg cgggcgcttt gcaacggctt caacggcacg tgccagtttg 2054461 ctgagtcctg tgacctttcc gcctcgcggg atatatgcaa catgtgcttt tccataaaag 2054521 ggaacaaggt gatgctcaca catagaatga aacgctatat cttttacaag aacaagctcc 2054581 tcatggtttt caccgaagat agtctggaaa tgttcttttg gatcttcatt caagccggag 2054641 aatacttcgg catacatctt tgcgactctt ttcggagtat caagaagccc ttctctattc 2054701 gggtcttctc cgatcgcttc taaaatttga cgaacagctt gttcgatttg ctctttatta 2054761 acttctttca tgttctatgt cctccaccaa tgaatacatt taatttcgat tctagcacat 2054821 atgccccgct aaaagcaaag tgaatgccct gtcaggaagc ccatgctctt gaaatatgaa 2054881 aagcccctta gaaaggggct tttctgtgaa gaaataaagt gtatgtaagc tagatgcata 2054941 cacgatctat attcacaatt attttccggc aactgcgtct ttaagcgctt tacctggttt 2055001 gaaagcaggt actttgcttg ctggaatttc gatttcttca cctgtttgag gattgcgtcc 2055061 tttacgtgca gaacgttcac gcacctcgaa gttaccaaaa ccgatcagtt ggattttatc 2055121 accgttttta agtgcatcta agatcgtatc aaaaacagag tcaactgctt ttgtagcgtc 2055181 ttttttagac aattcgcttg cttctgcaac cgcattgata agttctgttt tgttcatgcc 2055241 tttcacctcc tcccaaaagg atacattcag ttcgtttatt atcatttctt cacagttcag 2055301 tctgattcta aacctgtctc agaaaaaaat gagagcaagt aagagaaaga caattaaacg 2055361 gctttttaag aaaaactgca ctctgaggaa tgtttgtcca acaaagtgaa gaatttctgt 2055421 atgtagagta acacatataa aaagccatat caagcatttt aaagcgtcaa tcccttgctc 2055481 gtcaaggatt taaggtgatt taccgaacga atattccttt ttttcctttt ttcatcctat 2055541 tccttgatcc ttttccatta ttaagagcaa agaaaaaaga cctcccattc tataaagagg 2055601 tctaccggta ttacaggatg atggcgatta agccgccaga gccttcgttt atgattcttt 2055661 ctaatgtttc ttttaattta taccgtgcgt tttcaggcat caatgacagc tttgcctgaa 2055721 tcccttctct cacaattgag ctcagcgacc ttccgaagat atcggaattc cagatggaga 2055781 gcggatcatc ctcaaagtcc tgcattaaat agcgtacaag ctcttcactt tgtttttccg 2055841 ttccgataat cggggcgaat tcgctttcga catctacttt gatcatatgg atcgacggag 2055901 cgacagcttt cagcctcaca ccgaatcgcg agccctgcct tataatttcc ggctcatcga 2055961 gactcatatc agctaaagca ggcgctgcaa tgccgtatcc cgtctgtttg accattttta 2056021 aggcatcaga cacttgatca tattctgttt tcgcatgggc gaagtcttgc atgagctcaa 2056081 gcagatggtc tcttcctctg atttcgacgc ccacaacttc ttttaggatt tgatcatata 2056141 gatgatcagg cgcgtacaaa tcaatttctg ccaccccttg gcccagctca attccggcta 2056201 atccggcact ttcaatgaat tcaaactcgc tgaattggcc gacaaccctg tctacgtccc 2056261 ggagccgttt aatatcctta accgtttcct tcacggactc ctgatagctt tcacgcaacc 2056321 aatggttttc tttcagcacc attacccagc ttgggagatt gacattcact tctagcaccg 2056381 gaaactcgta gagggcctct ctgagcacac tcagcacatc tgattcccgc atgctctcta 2056441 cactcattgc caataccggg atatcatatt tttcgcttaa atcctggcgc atggcttccg 2056501 tttccgggtg atacggcctg actgagttga tgaccataat aaaaggtttg ccaacctctt 2056561 tcagctcttc aatgactctt tcttcagcct ctatatagtc acttctggcg atatctccaa 2056621 tggtgccgtc tgtcgtaatg acaactccga tggtcgagtg ttcttgaatg acttttcgtg 2056681 tgccgatttc agcagcctca tgaaatggga tcggttcttc gtaccaaggc gtattgatca 2056741 tccgcggccc gttttcatct tcatatcctt tagcgccggg cactgtgtaa cctacacaat 2056801 ctactaatct tatattcaca tcgagtccgt ctgacacatg aacagacatc gcctgattcg 2056861 gaacaaattt aggctctgta gtcataatgg ttttgccggc tgcgctctgc ggcagttcat 2056921 cctgcgctcg ggcccggtct gcttcgttac tgatattcgg gagcaccaca agctccataa 2056981 attttttaat gaacgtggat tttcctgtac ggacagcacc tacgactcct aagtatatat 2057041 cgcctcctgt tcgttcagcg atatccttga aaatatcgac cttttccaag tgatcccctc 2057101 ccggacttcc tatccttttc aattttatta agctctttca atcaaacaca ggacactata 2057161 tgtgtatgac gttgtcctat ttgaatatga catctttaga aaatttctca tcctcaatct 2057221 attaatataa aaaaaccttt ctccctattt gtatgcaagg gagaaaggtt cattcctttt 2057281 tcatatcatt ttctaaaaaa acaggttcct gtttgtcatt taccgtatat tttacagaaa 2057341 acgcggggac aaagggggtt tcatgccaaa tcatatcctg gatttcagtc ccgggtttaa 2057401 acgttttttt gctttttttg aggcaagaag ccagctcagt ccggtaatcg gcatatattt 2057461 ctccgtctcc gtcaatcata agcggcaagg aattccctga gattgggctt gtcactgtaa 2057521 gagagctgcc atccccaagc ttcttctcat cgagtgtaaa taaatcacga gatagcacat 2057581 ccttgtaagg cggatattga tgctcctgac gatacatttg gatgcgcaat ttcacatcgc 2057641 gaattttttc tgccatcttt agatcaatta atttaacagt cggatcgttc tctacgtcaa 2057701 caagcacgta ttgatagtct cccccgcttt caaatgccgt acttggaggt tcagctatgt 2057761 atcttggcgc taaccggtta aagtctatcg gatatttttg atatagcggt gtcgacatat 2057821 ctttggtttg aataggaagc agccctccat ttgccttttg aaattcatca acagcagatt 2057881 gaacctgctt tagctggtct tgataaggaa tggcatgcac actgcttttc cgttcatttg 2057941 gatataaaca tccggataaa aacacgactg ccgcaaaaat gattgcgcac ttcagtttac 2058001 ccatacagca cttcctttta cagctttatt cattgacagg gccgctaaaa accacgacaa 2058061 acacaataat tccagatatg agcatacaca tgtatgcgaa tgatgaaatc gcaatcttca 2058121 aaaaacggtt ttggcactta aagcggctta aatagatgga agctacagcc agaaacatca 2058181 gacccatgga ccctagagca aaccacattt tcatcaatgc cagattcaat gacgtgcgcc 2058241 tccccgatat gtaagatata agcgttatat tatattttaa tatacagcgc cggaaaagat 2058301 caaccagatt ttccatccat tgatagaaca aaaaaactga agcaaagagg gggaccttcg 2058361 cttcagtcaa cttgactata ttcacctgca cgtttaagaa acactctctt ggacttcgat 2058421 gctatagtat gcgacttggc atacagatgc atcctctatt gcctaaatcg gcaaaatgtt 2058481 tcaggagatc ccaagacttg ggtgttcttc tgtttttcgg gctttcgttc aattaagata 2058541 tgcgattcac catttgattg acacttttac ttcacttgat tttcaaacgt atttaccaaa 2058601 tcctccatct cgtgggtttt ccctctcgcc attaaagatt caacagcggt ttccactttt 2058661 tgtccgttga ataggacctg atggagagct tctgtaatcg gcattttaac atcatatttc 2058721 ttcgaaagct gataagccgc tttcgtcgtg cggacgcctt cgactaccat tcccatctct 2058781 tcaagaacat cttcaagctt gtaccctttt ccgagcaaat tgcccgcacg ccagtttctg 2058841 gaatgaacac ttgtgcacgt cacaatcaga tcgcctactc ctgtcaatcc agagaacgtc 2058901 aagggatttc cgcccatttt cgttccgagt ctcgcgattt cggcaagtcc gcgtgtaatc 2058961 aaagcagctt tggcattgtc accgtaccct aaaccatctg taattcctgc agcaagggca 2059021 ataatatttt ttaaagcccc tccgatttca actccgataa tgtcaggatt tgtgtacacc 2059081 cgaaaattgt gattaataaa tagatcctgc acctcttctg ctgccctcat gctctttgaa 2059141 gatgcagtaa cagttgtggg gtgccgcagc cctacttctt ccgcatgact cgggccggaa 2059201 aggacaacga tatcttttct gacatcactc gggagctcaa tttccataat ttcagaaatg 2059261 cgcagaagtg aatctggctc aatacccttg ctgacatgaa caaagactgc ctttttcgtt 2059321 ataaaaggga cagcctgtct cagcacttcc cgaattgctt ttgtcgggac cgcaacgata 2059381 atgacatctg cgtctgaaac agcctctttc atatctgttg ttcctttaat ggatgtagac 2059441 agcttaacat tcggcaaata atctttgttt tcatgcaact cattaatttg atgaattaaa 2059501 tctgcacggt gagcccacac acacacttca tttccattat cagttagaac taaagccagt 2059561 gctgttcccc aactccccgc tccaagcatt gtgacttttt tcatgtttga ttcacacctt 2059621 tttattttct agctcttgca aatattttga ttggtgtccc ctcaaaaccg aacgcgtctc 2059681 tgattcggtt ttctaaaaac cgttcgtatg aaaaatgcat cagttccgga tcgtttacaa 2059741 acacaacgaa gcttggcggc tttaccgaca cttgagtcgc atagtaaatt ttcaaacgag 2059801 aaccgttatg agtcggtgtc ggattcattg ccacagcgtc catgatgaca tcatttaaga 2059861 cgtttgtttg aactcgaagt gaatgatttt cactagcttt gataatcgca ggcatcagag 2059921 tatggatccg ttttttcgtt aaggcagaca taaataggat tggcgcataa tccagaaatt 2059981 gaaaatgatc gcgaatattt tcttcaaatt ctttcatcgt gctctcatct ttgtcaacag 2060041 catcccattt gtttacgacg atgacgacgg ccttgcccgc ttcgtgtgca taaccggcga 2060101 tacgcttgtc ctgttcaata atgccttctt cgccatccag cacaaccgcc acgacttctg 2060161 agcggtcaat cgcttttagc gcccgcagta cactatactt ctcagtcgtt tcatagactt 2060221 tccctttttt tcgcatacct gcagtatcga caatgacaaa ctcctgctgg ttgtaagtaa 2060281 atgacgtatc aacagcatct cttgtcgttc cagccacgtt gctgacaata acgcgttctt 2060341 cgccgagcat cgcattcaca agtgaagact ttccgacatt tggacgtccg atcagacaga 2060401 attgaataac ttcttcattg tatttcgttt caggaatgtt tttaaaatgc tctgcaacgg 2060461 catccagtaa atcacccagt ccgagtccgt gtgttcccga aattggatac ggctcgccaa 2060521 agcctagcga ataaaaatca taaatattcg ctctcatttc tgtgttatcc agtttattaa 2060581 ccgctaaaac aacaggcttt tttgtgcggt acaaaatttt cgccacttct tcatcagcag 2060641 ctgtcacgcc ttcacggccg ttcaccataa aaataatcac gtccgcttca tccatggcga 2060701 tttcagcttg ctggcgaatc tgcgctaaaa acggctcatc accgatatca ataccgcccg 2060761 tatcaatcaa attaaaatca taattcagcc attcagccga gctgtatatc cgatcccttg 2060821 tcacgccagg ggtatcttct actattgaaa ttctttctcc cgcaatccgg ttaaagattg 2060881 tggattttcc tacatttggt ctcccgacaa tggctacgac aggtttaccc atagtaccct 2060941 tcctttcaat ccagccgctt tcatttttac ataaattttc aaccggttat taaaatcatt 2061001 tcattcactt ttatgaaaag aaacccttca gaggaagggc ttaactcatt tattatatca 2061061 gtttttactg ggatcacaac tattcttaaa aatgtttcac gatcaaatac acgtcatctc 2061121 cgattctgtg agctattcca tcaaggatcg cctcaagatt tttagcgaaa agctccatct 2061181 ccttttggtc attgcaaaaa aagacaggtg ctccccctgc aacccgattt cgatttgtcg 2061241 tgattacaga caaaatcact ttcgtaagag attcactcat cctatcacct tatcctgatt 2061301 cttgataaat tcagtcggca ttctaatcgc attttccagg gttggaacat tgctaataat 2061361 ttgaacagcc gtttcgggat ggtgaatttg cgggagaaca aatactgcca ctctcccatc 2061421 atttaaatcc cgttttgcaa ttggtgtcaa agatggctct cctgaatccc gataaacccc 2061481 gagcacattg gaaacatcaa ataaaatggc ctgacgctgc cctaaatttg ctatcgtcgc 2061541 tgctgaatta aagtttttcg gcgtcaaaat aaagcccatg ccatgcttta aaatcagttc 2061601 ctgtttctct ggaagcccga tattcatcat ataaatatta tcaacaaaca gtcccggacc 2061661 gtcaaagcgc ggctttatgt actcgatatc tacaatatcc ttcaacacac tgcccgacat 2061721 aaacttcatg gccagtaaaa aacaaacgac agccgctatg actgcagccc agatggataa 2061781 aaacacatac gcagaggttg tcaaaagcgc tgtaaagatc acaatataat ttctgctttc 2061841 aaacgcaatg gcaatcccct caatatatgt gcttcccctt gagacaagtt catacgaatc 2061901 catttgcgtc aatgtgttcc gctccatgtt tcggacatct ctaaattgcg tcgctgccaa 2061961 tgttaaaaat gtgatggccg taaattcctc ctgcaaaagc gccggcataa taattgcacc 2062021 taaaccagcc gctatcaacc ccagtgcgat gtgaatcact ttcccatgaa cataggtcgg 2062081 atactggcgg taatccgttt tcagcatata aagccttgtc gcaattccgg caatgacccc 2062141 agcaataatc ggatagatgt aatcactcat gacattttgg tagctccttt gtttgatctt 2062201 ttgcttttct gaccaatctg gcttgcgagg tgttcgtatt tagatatgcc aaacagcaat 2062261 atcatccccg cagaacacgc attcagccat tgaaagccgc cgacagccat agccccggcc 2062321 aacttctgga tcacaaatga atacaccagt tcgccttggc acatccctag gacaaataag 2062381 acaagctgct tctcaaaatt cctttcaaca gaagctgtta aaagcactat taatataaca 2062441 gcagcccact caggttttat gatgaaccaa accgggtcat ataatgcaaa aagataaaca 2062501 aacgcatacg cggcaacaag cgtcagatag accatgatgt aacgaaaacg atacattccc 2062561 aaatacccgg catagacaca tccgcaaacg aaaaacatca aatatgcagc attcagggaa 2062621 aaatataaag cgatgtcatg tatgcttaga ataatattag ttaaaataaa gacagagacg 2062681 gcaattcgtc ttttcgtctt ttcaaaaata aatgttgtca gaacccacag aaaccacatt 2062741 gaccaatagt aataaaattg ttccatttta cttcctccat attcccagta tggagttcaa 2062801 gcacattttt taaacaatcg atctcacatt aaggagtatg atcatgggaa aagacagaca 2062861 agagaaaaaa ctcaaagctt caggcagagt cgaatcagat cgcgaccagt ccattcacta 2062921 tgacggagcg acaagccttg aacaaaacgg aagattcaaa aagcgaaaat cataatacaa 2062981 aaagcccaaa ccacatatgg ttttgggctt ttatcattta tcgcacacta tagcttgatg 2063041 tattgacccc tctctctgtg agccaatgat gggtttcacc tttgatcaca aggggcgcct 2063101 tttgtaaatc ggcaattgtt ctggcaccca gcacggtcat aatcaacttt aattcctcaa 2063161 ggatcagctg aatctcctca agcagtcctt cctcaccgct gtcagtcagc gcttttaaaa 2063221 aatgccctgc cattccggtg caagaggccc ccagcgcaat tgcctttgcc acgtcaagcg 2063281 catcttgcag accgccagag gcgatcatgg tgcttgcagg aaactcagag cggatttccg 2063341 ccaaacttgc agctgtcgaa atgccccacg aattaaaaaa ggagatttgc cgctgtcttc 2063401 ggagattttc gattttcgag aaatttgttc ccccgtaacc gccaatgtca acagctgcag 2063461 caccagcttc atacagcttt cctgctgatg ctttgctcat accgaagccg acttctttca 2063521 caatgaccgg tacactgacc cggctgcaaa tttgttcaat gcgtttcaat gcgccgctaa 2063581 agcttctgtc cccttcaggc atcacaattt cctgaatcac attgaggtgg atctgcagtg 2063641 cgtttgctcc aatcatctca acggcttcct ttgcctgagc agccgttgcc tcgcttccca 2063701 ggttggcaaa aatcagcccg tttgggtttt cctttcgaac aatttcatag gaaagacgct 2063761 ctgatggatc ttttaatgct gacatttgcg atcccacagc aaggggaatt ccagcctgag 2063821 aagccgctcg cgcaagcgat ttattaatct catatgtaag ttttccgccg ccgccagtca 2063881 ttgcattgat aaaaatcggc gaactgcttg aaagttcgcc gatttttgtg gaaatatcta 2063941 cttgttctaa tgcaagatcg ggcagactga cgtgaacaaa cgtaatatca tcaagacctg 2064001 tttcccgctt ctggccgatg gacaaggcat gattgatgtg ttgtcttttt cgttctgctc 2064061 gagtcacgtt tatcaccaat tattttagtt tattcagctt atctccgatc agatctccaa 2064121 gctggaagcc agtgcttgtt tcttccttcg cttgatattg acggtaatct tcctggtcag 2064181 ctttaggcgt ttcttcaagt tcacgcatgc ttaatgaaat gcgctcctca ttttcattca 2064241 catcaagaac cttcactttt acagtctgtc cttcttcaag gacttcatgc ggcgtgccga 2064301 tgtgtttatt ggaaatttga gaaatatgaa cgagaccttc aacacctgga aggatttcaa 2064361 caaaggcacc gaagcttaca agacgctgta cagttccttc aagcacatcg ccaggcttca 2064421 ctttttcgcc gatttggttc caaggtccag gcagtgtatc tttgatcgat aaagaaatac 2064481 gttcattatc acggtcaacc gataacactt tcacttttac ttcttgtccc tcttcaacaa 2064541 cgtcagacgg cttctctaca tgagagtggg aaagctgtga aatgtgtaca agtccgtcga 2064601 tgccgccaat atcaacaaac gcgccaaagt cagtcaggcg ctgtactttg ccatcaagta 2064661 cacttccaac ttcaagagac tgaagaagtt cttgtttttt attcgcttgt tcactttcaa 2064721 caacagcacg gtgtgaaagg atcacgcggt ttttatcacg gtcaagctct acaacgagca 2064781 gtgacagtgt ttttccttta tagtcagtga agtcttcaac gaaatgtgct tcaacaagtg 2064841 atgccggaat aaaaccgcga acgccgatat caacgacaag gccgcctttc acgacatctt 2064901 tcacttcagc ttcaaacact tcttttgttt caaatttttt ctcaaggtct tcccaagcgc 2064961 ggtctgcatc aacagcacgt ttagataaaa tcaaagcatc gtcttccact tttgttactt 2065021 tcaggtcaag ctcgtcgtct actttaacaa catccgatgc tttctctaca tgaagacttg 2065081 ataattcact gattggaata ataccggatt gtttgacatt gataatttct acatctacat 2065141 gtttgtcttc tacctttgtc acaatccctt taactacatc tccaacctct ggcacttgaa 2065201 catcaatttg attcatttcc tctgtcattt gaataacctc cttggtccaa acctacacag 2065261 cttaattaaa acggtttgaa agctgaacat ataacatgcc cgcttttagc cgaatatgta 2065321 ttaaagaatc atccaaaaaa gttttttgaa tgatcaataa aaagttttat tagtattaac 2065381 ttctaataaa aggacaggtt tgtcaagcaa taacattcta tcttcgttga aaaattcaaa 2065441 aaaagtggca tttgccatcc tcagcgggac ttttgctcca cagcctcgag gattttatca 2065501 gctacctctt gaatggaaag cgatgtcgtg tcgatttcaa gagcgtcttc tgctttacgc 2065561 agcggagata cttcgcgctc tgaatcaagc ttgtctcttc ttgcaatttc ctcaattaat 2065621 gtttcgtagt tgacatcaaa gccttttttc acattttctt cataacggcg tttcgctctc 2065681 tcttccacag atgccaaaag aaagattttt acttctgcat ttggcagcac atgcgtcccg 2065741 atgtcacgac catccatgac gacgccgcct ttttccccaa gctgctgctg gcgtttcacc 2065801 atttcttctc tgacacttct gtgcttggcc gcaattgaaa cttggttgct gatttcatct 2065861 gttctgatcg cctcagttac atcggtgccg tttacaaaca ctttttgtcc atcttttgtt 2065921 gtaatcagct caatgtctgt ccgctttagc agctcagcca gtttttcttc atctgtcaga 2065981 tcaacgtttt cctgtaaagc cgcgtacgta atcgcccgat acatcgctcc tgtatcaata 2066041 tatatgtacg attttttctc agccacaatt ttggcaacgg tgcttttccc cgcagctgcc 2066101 gggccgtcga ttgcaatcga taatttcttt tccataattc ctctccttgc tcttttctcc 2066161 tctaaggatt gtatcacgaa ctttatgaaa aagggtgaaa aattgatgaa taattaatgt 2066221 ttgaaggttt caatcctatt gttttcctcc attttatcca ccccttcata ttgaatcact 2066281 tttgatacgt atggttcaat atgctgatag tgaaaaagaa attggacacc aagtaaaatg 2066341 atggcctgaa tgaacaataa tttgatcagc agccgttcaa atgttttcat tggagcacct 2066401 ccattacaaa tagtatggaa gtgtttgccg atgtttattc cattcgggcc tttcttctct 2066461 tatttaactg gcgcctgatg cagtattgaa gcaaagcctg ctggtcacct gctgcaattt 2066521 ctgaatactc taaagtcatt tttcgttttt ctgacttggg gtcattaaag attcgtctga 2066581 caactgcttc tgtttctatt tgacgtgtgt gctcctcttc aggaagacgg atgatcaggc 2066641 gcaatgattc ccccgattga aaagaaaggc catcagctaa aaccacggcg atgccgcctg 2066701 cactgatgtt ataggatagt gtgcggatct cttcttcatt tcccggctga atttgcacat 2066761 ctaataccgc atcagttctt acatattggc ggcgctggat tcttttcatt ttttcacggg 2066821 gaggcatttc aagacagatc atttgaagtt tgtccttcac tttacctttt atacggctta 2066881 taaagcgata aggaacttcg tcttttccca caaactctac cgttacttcc atatcgttat 2066941 gtaaaatcac agttcgccct gtaactacat caacaggata cgcgatcaaa agttcattgt 2067001 tttcgatgct gaccgccttg ctttttgcct ttttcaattc attttcttct atatattcta 2067061 aaagtacatt ttctccaatc tctatcattg acttcactct ttcgcattca atatactcac 2067121 gtttttatta aagcacgtaa tgaaaaaaag gaaaagacat ttagtccttt cctcctgttt 2067181 ttataggtct ttatatatag gttctgcatt ttttagtttt tcaacctttt cttccgatcc 2067241 gtctttggca ttgatataca ttctgaatgt gtcattttca attgtcccaa gcatttcgta 2067301 gcataacact tcttgaccta gttcatttgt aatcaaagcg agccttgttt ctctcacttg 2067361 tacattttta tttaatttag actttgcctc tgcttcagta attgcaggct taggtatggt 2067421 tctttttctg tgagatgtga ggaagtctct tgctgaaaag ccgacaacct caccgtcatc 2067481 caaggccact ttcatacgaa ttgcctcggg gtacatccgg actttatttt caacaggaac 2067541 atatgaaaat acaccgattt tatcatattg ggcactttca tcaatttcca aatcatctgt 2067601 ttcaaatccg tttttcttta aaaatgcaag cgctcggttc gatccgtcat ttaaactgat 2067661 tttctgatct ttcacttctc tgttttggat caagtatacc ggatgcccgc ccttcttcgt 2067721 aatatccata taaatcactg ctttatggtc tgggtctttc atgctgatgc tatatacatc 2067781 gcgatttgtt ttttttccgc tctttaccac tttaattgaa taattgtcat ctggggcaaa 2067841 gcgctcagca atttgttttg cttcctgttc ggaaatttgt tttcccttca gatggctgaa 2067901 gcctttctct tcttttttcg tactggtgaa actcgggcca agatcagtgc cagtggagaa 2067961 tgcaccaaca tttttttcga ctgttttaaa gctgttgata atcgtattat cactttgttt 2068021 ttcgtcagaa gccagagcca tttctacgtc catccagcga aggtttttgc tcatgacaag 2068081 gtgctgaaca tgacgcaatt cattttgtat atcttcggac tgctgatata gcttatttag 2068141 tgatgtatac tcgtttttat caagcggctt ttggtccaaa tctctgactg acgttttata 2068201 gctgaaatcg ccgatctttg ataatagctc ttcagtttta ttaaacggca ttaatgtaag 2068261 cggcagctga ctgacgctgt tatgagcttc tgatgtaatc ctccacacat cgatcaatgc 2068321 aggcgacagt gatttttggc tgttcatggc aagtgttgtt ccgattttat catgaagctg 2068381 atccacctga taggtaagct catgaaacgc ccgctgatag ttattttcag catgaagaag 2068441 aactgcgtct ttttcctggt gttctttgta tccccagtag cctgtaccga ctattgcaat 2068501 accaagcacg gcgattaaaa ttcctctgat catttatcac acctcttttt atgctttctc 2068561 atatctgcta ctcacagaaa atgtgtttac cgattctttt aatctgcgga cgcccccaaa 2068621 tccacggact tgtagccgta tccggattaa agtagtaaag tgcttcctct gatgggtccc 2068681 agccattgat ggcatccagc actgcttctc gtgccgtttc attcggctgc atgtaaattt 2068741 gtccgtcggc tactgctgtg aaggcaagcg gctcaaaaat aacccccgct actgaatttg 2068801 gaaataacgg gctgttcaaa cggtttaaaa tgactgctgc aatagcaacc tgcccctcgt 2068861 acggctcgcc ccgggcttcg ccataaaccg cttgagcaag cagcctgata tcgttgttgg 2068921 aaaatccacc aggcatgttc gctgctaccg catcctgttt tcttgctttt gctggtgtat 2068981 tgttttgctg tttattcgca ttcgctttag gcttctgcgt tgttttttcc gcaggctgtt 2069041 tctgccgtgc ttctgcttgt tgtcttgcct tttgtgttgc tgcttttgat ggtttcgtct 2069101 gatactttag cggaattttt ccgtaatgcg tgaatgtatt ccctttattg agctgttcca 2069161 tgacatattc acgatagtat tttgatttac atattaaggt ttgctttgtt ttagctccta 2069221 caaggccgtc aacctctttt aacccgaatt gatcctgaaa atttcgaact gcccagtacg 2069281 tcccccatcc ataaaccccg tcaatttttc cgttataata tccgttgtat tgaagacgcg 2069341 cctgaagctc gaccacatca tcccctgttg cccctctttg aatgacctga ttcgaaaagg 2069401 cagagatcgt ttcagtatta ataaacgtcg ttattgtaaa ggaaaaaagg atgagacatg 2069461 ccataatcga tcctttggac ttcatctttt caagcctcct actgcaaatt tttaagtgta 2069521 atcgtatttt ctgtaacgag gttattttta tacactcttt ccttgttatc cctcagaaca 2069581 taaaaactgc acacaaaaaa gccgcacggt tgctgtgcgg cttctatact tgcatcatat 2069641 taacggaacg ggcttttttc gctttacgca aaccaaacca ccataaaaat accataaatg 2069701 gaagcatata ataaatccaa ttgctaagcg ctgttaggat aaaatcatat gatccatgca 2069761 aaagggatgg gacaactaaa gaaagagtaa gccactttac acgcgcctta tcagcggaaa 2069821 aacgggcttt tccaaggtaa aatcccatta taacgccaat caaggcatgg catgaaacag 2069881 gcagcagcgc cctgacaaac gcatgctcca cgccgtggcc aattaaataa agaatatttt 2069941 cgagggttgc aaaaccgagt gatacacttg caccgtacac aatcccgtca taatgctcat 2070001 caaagtgggc gtgcgggtaa acactgatca tcagtataaa ccattttaat gattcctcca 2070061 aaaaccccga agataaaaaa gaaacgaaaa agcttccgcc tcctacattc tctttttcaa 2070121 gtacatactg gataaacatg atgggaaata caagaacaac cccgagaaaa aacgaccgta 2070181 gcaccatatg tacaggttca ttatcatact gatcttttaa ataaaaataa cttaataacg 2070241 cgatgccggg ggcaattcct gcagagatga ttgcaaacat caggcaacct ctttccttta 2070301 tattcctaca tctatcctac catgttgttt aaaattttac atctgtctgc acttaaaaaa 2070361 acaaaaagag catacgaatg catcatatgc tcctcatctt taatggtttt ctcttttggc 2070421 gatttccgct gcgatatgcc ccccgtgaaa cctgccgttt tcaataaata tttcatttgc 2070481 attgtttccc gcagcaataa caccggcaat aaagacacct tcaacgttcg tttccatcgt 2070541 ttcttcgttg aaaaatggac gccctgtttc tttatcaatt tcaacaccaa ttttttcaag 2070601 aaattgatga tcgggatgat agcctgtcat ggcaaataca aaatcatttt taatggtaat 2070661 gagttctttc tctccggagc gaaacacaac ttcattctcg gtgatttttt cgacacaagc 2070721 tccaaattcc atacggattg taccgtttct gacgagagct tcaaattccg gcagaatcca 2070781 cggcttaatg ctcggagaat actcattgcc cctatataaa actgtgacac gcgccccaga 2070841 tttcacgagt tcaagggcgg cgtccacgct tgaatttttc ccgccgatga caacaacatc 2070901 tttatcaaaa tacgggtggc cttctttaaa ataatgaaat actttcggca aatcctcacc 2070961 gggtacgccc atatagtttg gatgatcata atagcctgtg gcgatgatac aatatggcgt 2071021 cgtgtaggtc tcttttgacg tctcaataac gaatgtgtta ttttgcgttt tcgtcacttt 2071081 acgcaccatt tcaaacgcat taacacggat gtttttccgt ttaacgactt cccggtaata 2071141 cgataaagcc tgaattctga caggcttcct gttctctgta ataaatgcca catctccgat 2071201 ttcgagcttt tcacttgaac tgaaaaaggt ttgatgcgtc gggtaattgt aaatactgtt 2071261 aacgacattg cctttttcga tgacgagggc atcaatgcca atttgtttta ggtgaatggc 2071321 agcagatagt ccacaaggtc ctccgcctat aataattgct ttttcttgaa tcatttctgt 2071381 caactcctgc gattggcatt tcacttcata ttttctattt ccgaataaaa aaatctccta 2071441 ttttatcata ggagattttt tatttttatg caaatcatca acttatatcc agcctctaaa 2071501 acgcgaagct tcagccattt tgcgaacgcc gaccatatat gcagcgagcc tcatgtcaat 2071561 tcttcggttg ttagccattt cgtaaatatt gttaaatgat ttgaccatca ttttttctaa 2071621 tttttcttct acctcttctt cactccagta gaagccttgg ttattctgaa cccattcaaa 2071681 ataagaaact gttacgccac cggcacttgc cagcacgtct ggtacaagca gaatgtcccg 2071741 gtctgaaaga atttttgttc cttcaagcgt tgttggtccg ttcgctgctt caacgacaat 2071801 tttagcccgg atattatggg cattttcttc tgtaatttga ttttcaatcg cagcaggaac 2071861 gagaatatca caatccagct ccagcagctc ttggttggta atggtatcgt tgaaaagctt 2071921 tgttacggta ccgaagctgt cgcgtcggtc gagtaaataa tcgatatcaa ggccttccgg 2071981 atcataaagt ccgccatacg catctgagat gccgacaact tttgcccccg catcatgcat 2072041 aaattttgcc aaatagcttc ccgcgtttcc gaagccttgg acaacgacac gcgcaccttt 2072101 aatatcgatg cctctcttct tagccgcttc tttaatacag atggtaacac cttttgctgt 2072161 cgcagattct ctcccgtgag atccgccaag cacaagcggt ttgcctgtaa taaatccagg 2072221 cgaattaaat tcatcaattc ttgaatactc atccatcatc caagccatga tttgtgagtt 2072281 tgtaaataca tccggtgccg gcacgtcttt tgtcgggccg acaatttggc tgatcgctct 2072341 gacataccct ctgctcagac gctccagctc tctaaacgac atatcccttg gatcacaaac 2072401 aattccgcct ttaccaccgc catatggaag atcaattatg ccgcatttta aactcatcca 2072461 aattgaaagc gccttcaccg ccttcacctc tttttctgtt acgttcgggt gaaaacgtat 2072521 cccgcctttc gttggaccga cagagtcatt gtgctgcgca cgatatcctg tgaaaatctt 2072581 tactgaaccg tcgtccatac gaacaggtat ttttaccgtt aataatctca tcggctcttt 2072641 taacaattcg tatacctctt cgggatatcc caatttttcc agagccttat gtattacggt 2072701 ttgggttgat tttaatacat caagtttgtc ctcttctgta tgaccggtgt ttcgatcggc 2072761 tgccatttga gttaacctcc tagaatcttc tgtttctcac atgctccctt tcagagaata 2072821 gtatacacct tcatatgatc tgtgcataga ataaacgtta tgtttttcca tgttttttaa 2072881 cgaaaaaaaa ctgctgaaat cagcagtttt ccgttgcatt cttatgaaaa atgagtttgt 2072941 atcgtttcta cggcattacc gtccataatg agcttaccat actcttgcag gcgataaatc 2073001 gttaaagttg tcggattgcc gtattcagcc agaaccgcca caaccccttc agccgtatgt 2073061 gaccctagat cttcaaggct taaaaagtac tgcccgtcat agtggtagac agttccccct 2073121 gtgataccga ttcgctgtaa gctttctgaa agctgaatga tatcttcaaa ggaatggaat 2073181 tgatatatga tgtccgcgct ttcatcaagc ttgacttgca tttcgatgta atcatcatca 2073241 tactcatcgt cttctgaatc ggcgtcttgg ttctttgtta caatcacgac catcccttgt 2073301 gcttggagag aatacacttc cactgcaatc ggtccattcg cttcaaagcc gagctctgta 2073361 tttgcttcat tcatcatatc tttaaataac tggtggactt taaatgagtc cttccagagg 2073421 tcttcttttg tcaatccccg gtctgtcaaa tcatcgaggg ttaaaaagat tttgatctta 2073481 ttataattca gacgctcaag ccgcataacg ttccctcctg cctctacttg cacacaaatc 2073541 atataacaca ttatatgaga tgatgagtca taggttctta attgttatca gtttacactg 2073601 agttcactag taagacaagc acaatgcagt ttttattgcc atacggattt ttgcttttta 2073661 gaagttattc tggcccgcaa agagtcacaa tgtgagtttc aggctcagca cctaaacgaa 2073721 gaggcacttt tgtcgtgccg tagccgttgc tgatcagata tgccgcgttt ttaacaatac 2073781 ctgttttccc cagttcataa ggaccgaatt ttccaaacct gatctggcct ccatgggtat 2073841 gtccgctgag tatcacatca ataccgtcat cttcattgat ttgttcatga atctccggat 2073901 tatggcaaac cagaatattc agctggcttt catcaagttc tttgatggct tcctcataat 2073961 gatccatctc catcctgata tcatcaaccc ccgcaatcgc aatcgtatgc ccattgtatg 2074021 aaaacgggac tgactcattt ctcagagtga tgacgccgtg cgctttaaat atggaataca 2074081 gcttatgctg cctgacttca taatcattat tcccccacac aaacacgata gggaccccga 2074141 aatgtacgag ccttttgatg ttttcctcga ttctcgcact gggcaccccg ccctcagcta 2074201 aatcaccgcc gattataacc aagtgggggg catggcttcg cgctttttct aaaaggtctt 2074261 gatcgatgag acgtttgtga atgtctgaaa taaaaaagat tgtcagaggc ggcttgccct 2074321 tcatctttga taaaggaaac gtatgtgtct tcaaatgatt gccttttgct gttgcataca 2074381 tttttgccgt cattgccgct gccgcaacag ttagtacacc ggcaattttc actgatagct 2074441 tcataaaaaa ctctccattc tttttagaac ttatcaataa gacggacaat aaaaaaagac 2074501 gtttctatcg tttgagaaaa cgccccattt tatttacttt caaaatatag attaatgtca 2074561 tatttgtgct tcatcatatg aaaaacagac tctctcgcct tccatttatc gggctgcggc 2074621 cagagatcag tgcttttctg aataatttca catctcagtt tatggaaatc agtctcggat 2074681 ttttcttcct ttttcttgaa ataatatgaa gtgcagtagg caaaagcggt tgccagcatc 2074741 caaaataaat aaaaggtatg gctaagtatt tcttgaagta taagctgagg ctccgggctt 2074801 ttgatcatga tcataacaca taataagcct aggcagataa gtgaagccca tcgccatctg 2074861 cggcattgtg ctgcataatt ttcgaatttt tgttttcgtt ttaccagcgc ttggagcatc 2074921 tgtttggtcg gcgcgtctgt aaactgatcc agctgattcc ataaggattc catacgcttc 2074981 acaccttgtc cattttcatt gctacaatat atgaacgtaa aataaaaata ataccctatt 2075041 catccattaa agggatgtcc aaaacttgtc cggtgtaaac atcatttcca ttcagatgat 2075101 tatatgctcg aattttttct tctcctgtcc ggcttttata atacttcatg gaaatgcggt 2075161 atagcgtttc tttcttttgg acggtgtgct tgacaacgcg attcggcaca ttttgaactg 2075221 gctcagctgg ctgttcttgc tgttgtactg ttgattggga agaggaagca gccgcggcgg 2075281 ttgcttcctc cttatttggc gagtcttctt tttccgctac agcagtctgt ttcttatcag 2075341 cagctgtttg ctcttttggc ttggaatctt ctggctcttt ttttgactcc ttctgcagtg 2075401 cggtttcttt agtgtctgcg gtatcgtttt tatcctctga tttcgggaca acctcatatt 2075461 tgctttggct gctgtcaata aaaacatctt cataatcgtc atgattatcc gggtggctct 2075521 ttagataaaa taaggtgact aaaacgataa ccggcacaaa tacaaatatt actgcgagta 2075581 ctgtgaataa tggcgttttt gttttgcctt gctttttttt ctgttctctt tgatttttta 2075641 cagattgtct tgtcggaagg ctttctccat catcgacata atcgtccgcc aatgcggcgt 2075701 tttgatcttc ataaagattc tgggcttttc ttctctctac tctcgacatg ttcgtcatgt 2075761 ttatccctcc tcacatgttc aaaacgaatc tgacaggcaa acacggcatc aatgataaaa 2075821 tgcgccgtca tcggaacaaa taagttgccg gtccattcat acatcagacc gagcaaaaag 2075881 ctgattgctg tcaccataat aaataacagc cattttgaca aataccgaaa gtgcagagcg 2075941 gcaaatataa ggctggccgt ccataaaccg atatgagtct gcagcactcc tctgaataac 2076001 atttcttccg cgaaagcaat cagaagcgtt aaaaatataa tatgagggat tgacctctta 2076061 ctgaatattt ttttattgat tccgccgtca tcatataaat gagacggaaa ccatttcatt 2076121 actgccatat cggctaaaat aacaataaca gctatagaaa caccatacca gatgattcgc 2076181 atatcgcgaa tgtcccagag ctttaatacg tcccgtacat cctcaaaaaa gaacagtcct 2076241 gctgcagcag cggcaaagat gatgagtagc tgcgtcaaat ataactgctt cagcatatca 2076301 tggtcagtca tatgctgaat ataatctttt tgctgtttca gttcagctca cctacagtct 2076361 gcaagctgaa tatccggtgc aattccgaac tccagctgtc taatggcgcc attttactcc 2076421 gttccccttt ttgttcatac aaggataaat caaaaccgca atgtgaacag cacgggaggt 2076481 ttccgtcatc aggctcgtat gattcatcaa agtaggttaa cagtgcctgc cttaaacagc 2076541 cgtcacgctg aagcaaaaat gatacacggt gcattttttc cagcttcagc tccatgcgat 2076601 atgaaatttc tttcttcatc agttcaactg atgtttttcc ctgcataaag agatgaatca 2076661 tcatacgggc ctgtgtctct ccgacgccat actgaagtaa tacgtcacgc agccttctct 2076721 catcccgctc ctccgtcttc tctagcacac ggattacgtc ggcgatttct tcagctgtga 2076781 cactctccat ctggataatt tgttcctgca attcaaaatc ccctggcgcc cgcagcaaaa 2076841 tgctgacact cggctttccg tcgcgtcccg ctctgccgat ttcctgcata aaagcttctg 2076901 ccgtctgcgg gagatgaaaa tgaatcacat atctgatatc aggtttatcg acacccattc 2076961 caaacgcatt cgtacaacat atcacatcaa gctggttatg aataaactgc tgctgaatta 2077021 aaatcctgtc ccctgactcc aaaccgccat ggtaaaagtc ggctctgctg ctcgttttgc 2077081 ttttaatttc acccgctaat tccttagccc atttccgtgt tggacaataa acaattcccg 2077141 gaccttgcag gttttcaacc agctgaatga ccctatctat tttttcggca gtatccgccg 2077201 cattttcaac cctcagtgcg atgtttgggc ggttgactga gttgagatgg cgtacagcat 2077261 gctgcagctc cagcaggttc atgacatctt gcagcgtttc ctttgtagcc gtggcggtca 2077321 atgccagaac gggtgggtgt ccaagttttt ttctcagctg tccgagcttt gaataatcag 2077381 gcctgaagtc gtgtccccat tcagaaatac aatgcgcttc gtcaataaca aataggctaa 2077441 tcggaacgct tttcaatttt tccaatacat atggagactg taaagcttca ggagacaagt 2077501 acaaaaattt atatcgatga atatgttcta aaacaaattg tctttcctgc ctgttaagca 2077561 tgctgttcaa agctgcagca cgcttttccc cccgggcttt gagctgctgc acctgatcct 2077621 ccattaaaga aagcagtgga gaaacgatta ataccatgcc atcaagcata taaccaggca 2077681 gctggtagca aagcgatttc cctcccccag tcgggagcat tgcaatggta tccttcccgc 2077741 tgagtatgct ttcaataatg tcctgctgcc cttttttaaa ggaagtaaaa ccaaaaaact 2077801 gatataacgt ttgctgtaat ttagtcatat tgctgcacct gctttgtcaa tgccagtctg 2077861 atttgaaagt agctgaaccg ctgttccagc ccgtcgcgaa tttgtttgat tttattcgtc 2077921 cgcatccgtt tggcaaactc tgcgatttga agctggtctt ctgctgatac atagtcatta 2077981 atcataaacg caggctcatg gagagaaatc tcgacaatgt ggtcttcaat cgtcgctgtt 2078041 ttcagctttc tgatttcagc aattcgctgt atcggaaacc cttgtttgac catctgccat 2078101 gttttcctcg tcgactctgt cagggcatta tctaagtgca catcagaaag gagatccttt 2078161 aacaaagcat cttcacactc cggaagagaa tgaataaaat aatgtaccga agcccaaaac 2078221 atgatataga cataccattc gtcttctttc agcgtatcag caagctgcct gctcgtataa 2078281 ccgatccgat ggtgcgaggt taaggagtag acaaaaattt gcgctgcttt gttttcaatc 2078341 tttttcaaat gcgcctcaag catggcaaaa aggctttttg ccatctctat atgatccgta 2078401 tgccgggaca ggtatttctt tacccagtga agtgtcttat gatcctttgt gacagggata 2078461 tactgcctgc tcccttgctg tttatgggat aggacctgca caagcagcga aagccttttc 2078521 caaagcacgc cggcagcctg ctgataatga gcgccgtgac aatgaacggg ccaaggccgc 2078581 tcgctaaggg catgtctcaa aactgctgcg ccgctggctg tcactttgta tgtatctgat 2078641 tcagacattg gcgcgagata tgaatgcttt tcaagcttgt caagcgacgc agaaatatcg 2078701 cttctcgaac attttgccgc cattccaaag tattttgcag tctgaaataa gccggcatct 2078761 tgaatggtct gtgacgatct cttgcctttg aataggtgaa aaacagcgct tcccgaccgt 2078821 tccccgttta ttttgcaaag acaatcgaga accataatat cgaagtaatt taatgacaac 2078881 ctatccacct acattcttcc tgacaaaaat cgttgatttg ctctttttat tttaacagat 2078941 ttcaaacaga aatcgacgtt taaagtcatc attaaggggg atgttatgta gataacccct 2079001 tatgtgataa gcattctcaa tcatttttct gttgaaatgt ggcagcaaca tcattacaat 2079061 aagtaagagg aataggtgtt aaattgatta aatataaaga ttgatccatt tgttccacca 2079121 agaacaatct gggaggtttt attcatggca aagtacacaa tcgtagacaa agatacatgt 2079181 attgcatgcg gcgcttgcgg agctgctgca ccagacattt acgattacga tgatgaaggc 2079241 atcgcgttcg taacgcttga tgaaaacaaa ggtgttgtcg aagttcctga ggtactggaa 2079301 gaagatatga ttgacgcatt tgaaggatgc cctactgatt ccatcaaagt ggcggatgag 2079361 ccatttgaag gcgacccgct taaatttgaa tagaagtaac taaaaaaagc tcccgaacgg 2079421 gagctttttt atttaatgga tatgtgcact tcgctgctgc tcaatccatg gcttaagctt 2079481 gataaaaatt agtgagaata caaccgtaat tacaatacct tttatcatgt taaacggcag 2079541 gatacctgcg acgactgctg tttttagcgc gctgtcggat aatgccggtg aatgtaaaaa 2079601 ccacgtgtat gccggaagaa tcagaacata atttaaaata ctcattaaaa tggtcatcgc 2079661 tgcagttccc aaaagcaggc tgacagccaa gccctttgct gagttgagtt ttttaaataa 2079721 gaaagcagtc ggtaatataa agagtgttcc tgcaataaaa ttcgcaactt gccctacagg 2079781 aactccggcc atgcttccct gaatgatata ctgaagaaca ttttttatcg cttctacggc 2079841 aatacccgcc aaaggtccgt aaatcagaat ggcaataatt gcgggaacgt cgctaaaatc 2079901 gatttttaaa taatccggaa gacccggaaa cgggaaattt aacagcatca aaacaaatgc 2079961 aatgctgctc agcatgctga ccacaactaa tttttttact ttcacttcat tctctccttt 2080021 tcgatcacat cttactcgaa aacggaaagg ttcttttcca gccaataaaa aaaccgcttc 2080081 atatataaaa gcggggtttc gaaaattagg ctaggcaaag aaacgtttga aaaattcaat 2080141 ttcaaaacgc ttatgaacct ccatcttctc ccatccagac tgtactgtcg gctccggaat 2080201 ctcaccgaat cctgctgtaa agacagctcg cgggcttaga gccattggct catcaccgcc 2080261 ggtagggaat ttcaccctgc cccgaagatt gatcatatga aatttaatta cattataaac 2080321 gataactggt tggctgtata gagaattgct tcaaattaaa tatattacct gcaagctgtc 2080381 agatcattga tttattaggc tttactttta tcctttactg cgtcaataca cgttgacact 2080441 cttttgagaa tatgttaaat tatcagatat ttagtttgtc aatttaggag gaaatctaac 2080501 gatgtttcga gtattggtct cagacaaaat gagcaacgac ggtttacagc cacttattga 2080561 atcagacttt attgaaatcg ttcaaaaaaa cgtagcagat gcagaagatg aattacatac 2080621 ttttgatgct cttttggtgc gaagcgcgac aaaagtaaca gaagaccttt tcaacaaaat 2080681 gacttcttta aaaattgtcg gaagagccgg tgtcggtgtc gataatatcg atattgatga 2080741 ggctacgaaa cacggggtaa tcgtgatcaa tgctccgaac ggcaacacca tttcgacagc 2080801 tgagcataca tttgcaatga tctcttcttt aatgagacac attccgcagg ctaatatctc 2080861 agtgaaatcc agagagtgga accgcacagc ttatgtcggt tcagagcttt atggaaaaac 2080921 gcttggtatt gtaggattag gccgaatcgg aagtgaaatt gcacagcgtg cgagagcgtt 2080981 cggtatgact gtgcacgttt ttgatccttt cttaacggaa gaaagagcga aaaaaatcgg 2081041 cgtaaacagc cgtacatttg aagaagtgct tgaaagtgcg gatatcatta ccgttcacac 2081101 gcctttaaca aaagaaacaa aaggcttatt gaataaagaa acgattgcaa aaacgaaaaa 2081161 aggcgttcgc ttaattaact gtgcgcgagg cggaattatc gatgaagcag cacttctcga 2081221 agctttggaa aacgggcatg ttgcgggagc agcgcttgac gttttcgaag tcgaaccgcc 2081281 agttgacaac aaacttgttg atcatccatt agtcattgcc actcctcact tgggagcatc 2081341 aacgaaagaa gcacagctca atgtcgccgc ccaagtgtca gaagaagttc tgcagttcgc 2081401 aaaaggcctg cctgtcatgt cagctatcaa cctgcctgcc atgacaaaag atgaatttgc 2081461 taaaattaag ccttaccatc aaattgcagg aaaaattggc agccttgtat cacagtgcat 2081521 gaaagaacca gtacaggatg ttgccattca atatgaaggc acaattgcta aacttgaaac 2081581 atcgttcatt acaaaagccc ttctgtcagg ctttttaaaa ccgcgcgtag actctactgt 2081641 taatgaggtc aatgccgggg gtgtcgcaaa agaacgcggc attagcttca gtgaaaaaat 2081701 ttcctcttct gaatctggat acgataactg catcagcgta aaagtgacag gagaccgcag 2081761 cacctttact gtaacggcta cgtatattcc tcatttcgga gaacgaattg tcgagatcaa 2081821 tggatttaat attgattttt atccgactgg tcacttggtg tatatccagc atcaagatac 2081881 aacaggtgtc atcggccgag taggacgtat tctcggagat aatgatatta acattgcaac 2081941 tatgcaggtt ggccgtaagg aaaaaggcgg agaagccatc atgatgcttt cctttgacag 2082001 acatctggaa gataaaattg tgaaagaact aacaaatgtc cctgatattg tgtctgtgaa 2082061 gctcattgat ctgccataat taaaaaaact caagctatat agcttgagtt tttttattgt 2082121 tctatccccg tgtgttttta tgcaaaatat ctaagacact ccttagctca gaaacaggaa 2082181 tttggcctgg tgcggacgcc tcttctccag ctccaaaagt acaagccgat ccaaaaacct 2082241 caccgctcag cctgctgatg agccctgttg cagccattga cattgtaata atggggcggt 2082301 ctgcatatat tgttttcatt gtatacgtcg catcaagcag tgttaggaga tctccagtat 2082361 cattcggcat gacagccatt tttggaatat gcgcgcctaa gtcctgcatt tttcgaagtc 2082421 tggaaataat ttcatctttt acaggtgttt tttcaaagtc gtgatttgac atcaccacat 2082481 agacgttgtt ttcttccgcc agcgatacta acgcttttac atttgcatct cctgaaaata 2082541 attcgatgtc tatcagatcg atgtcttttg tttggattgc cgattccagc aaagcaagat 2082601 aggagctttc gtccatctcc atgctcccgc cctctttgtg ggttctgaat gtaaatagaa 2082661 atagcttgtc ttctaaagat ttacgaagct tagaaatgag ctttgtgacc gcttctctgt 2082721 cattcgcttt ttcaaatacg tcgactctcc attcaacaat gtccggattc agtaatttta 2082781 ctgcctctgc ttcattcaga atttgttttt ccgtctttcc catcagcgga atgatgattt 2082841 tcggcatccc ttccccgatg gaaactcctt taatcgttaa cacgttcact cgtctcaaat 2082901 cctttcaatc tttaccttgt tttattatac acgtacaact tttttttgaa aatttctatt 2082961 atatgaatag caactaaaaa agagccttaa agggctcttt ttagtttaag gaaatcggat 2083021 ttggagcagc tggcaccgga attgcatctg atatgtcata tttgccgatt tttttcgttc 2083081 tggtttccgt aaaggtcact tctgtgaagc caaactcttt tgcagtcaaa agtagtccct 2083141 caatcattaa aataccggca atagaatcat caacttctga ctcctttgaa aagcggatat 2083201 ataagtgttt ctgtttcttc gttacagatt ggacagcacc cgcttgaata agaggtgtcg 2083261 tatcttcttg gctgctcgat tccatttcct taatcgcttc ttttactgta tcaaaagaat 2083321 gatttgacgg aacgagaaag tcttgtcctt gtttattttg gtacaagtag taggatcgtt 2083381 ttgactgttt gggaatcgaa atttccgtaa aagtgccata tgagccaatc cgaaccccag 2083441 tctcattttg atccgataaa aatttgactt tttcataagg actccatttt aaggattctt 2083501 taagcaattt ttttaacagt gtatcatctt ttatagaaaa tgccgtagct ggctgatgga 2083561 ctcgtatact taattccttc tgctttggtt tttcctttat ttctacttca tctatgaagg 2083621 ttggaattgt aatggcatga tcaaggatgc ccaattcact actttcaaac agcatatcct 2083681 ggatcgtttg gtctgcattt gttttttgaa tgctgacggg tatgattgca gatgtatcgg 2083741 catcagcaac cgctacagtg atgtaattgt cttgttcctt ttcaggaacg acaaacgatg 2083801 tctgatccaa ggacgatgca gcttttgggc tgtcttctgt ctcagttttc gttactgcgt 2083861 tctcttggga cgcttctttt tgttgaggct gtgcctgatc aaagaaatga ggagaaataa 2083921 tgaaggcgat ataaaccgca attgcagcgg cacacgcggg gccaatccac ctgacagcgg 2083981 gcttattttt acgctttgcc atcgtcagcc gcttgtaaat atcctgaggc gaacgatggt 2084041 ctttaactgc cggaagttga cttaacaact cctttatctg ttcttcgttc cattctgact 2084101 tcatcatcca ttagctcctc cctcaaaagc tccatatgtt tccgaagtac tttgagccct 2084161 ctgtgttggg tcgtttttac tttgctttcc gagaagcgca gagccttggc tgtttcctgt 2084221 attgaatatc cctgaataaa ccgcaagata atcacagctc tttgatcgat tgtacattga 2084281 tcaagcgcag cataaatttc ccggacattt tcatgttgaa ccgcaagttc gtccggcagc 2084341 aattgctgat ccctgacatc ctgtgtatcc cagtcaaatg taccgagtat acgctgtctg 2084401 attgtttgct gtttacggaa ccagtctatc gcaacatggc gtgcgataga caaaagccat 2084461 gttttttcac tgcttcttcc ttcaaacgta tgataagaat ttaatacccg gatataaacc 2084521 tcttgaagaa ggtcttctgt ctggttttta tcctttacca tataaaataa aaattggtac 2084581 aaatcttgat gatatgtatc atataataat tgaaaggttt cttccatttg aaacccctcc 2084641 gttcactttt ttgtcgtatg aatagcttga aaagttacat tacaactata ttacgagtaa 2084701 ctggaatttg gaagggaatt tatattaaca tatccttaaa ttttattaat gttggctatt 2084761 aaaaaaacac ccgctcagtc agcgggtgtt tcttatggaa caagattctt cggcaaattc 2084821 agactcgatt ttaccgtttt gtcggaatat aaaaagaaaa tgttgttcct ttatctattc 2084881 ggctgtgcac agtaattgat ccgttgtggg cttccacgat atttttaacg atagccagcc 2084941 ctaacccggt tcctgctctg ccccttgtcc gcgctttatc tgccttataa aaccgctcaa 2085001 agataaatgg cagatcttct tccggtatgc cagacccgga gtctttgata tcaattttca 2085061 atccatcctt cacagaatgg actgaaatgg agacactgcc gccggctgaa gtatgccgca 2085121 gcgcgttatc aatcaaattg gtaaatacct gctccatctt gtcttcatca aacataaatt 2085181 cctcttctgt gagagaaatg tcatgatcta aagcaatatt tttttctttc gcaacaccgg 2085241 aaaacttccg aatgatcttt tctaaaaact cattcacatt gattttttca taatgtaagc 2085301 ctgtatggcc tgattccatt cgggctaaat caagcaaatc attaactaaa cggcccattc 2085361 ggagcgattc gtcataaatg atttgggcaa tttctttccg gtcttcttca gagcttgcaa 2085421 tgtcatcgac aattgcttca ctgtatccct gaagcatgga gatcggtgtt ctcagctcat 2085481 gactgacatt tgcgataaag tcctcccgca gcttatcaag gcggcgttct tctgtcatgt 2085541 cacgcagtac ggcaaccgct cctctgacgt gcgattccgc ataaagcggc gacatcaaaa 2085601 gcacccatga tctgccttga agcgtcatct caatcatttg ttctttttca gtgctgacag 2085661 cgttttgaaa cagctctttt gcttcaggcg gaagattgtc gccttctttg atattcatgt 2085721 tctgttcata ataccaagcc tgaagaaaac gttcagccgg cgggttggtc acaagaatcg 2085781 taccgtcaat attaatggta ataaccccgt cagccatact gctcaaaatg ttagaaagct 2085841 gctctttttc ttgattgagc gcattgatat gaaagttaag ctgccggccc atttgattaa 2085901 aagcggtcgc cagttcaccg atttcatcct gagttaaaat cgggattttt gtatcgaact 2085961 tgcccttcgc caaatcctgc gcgccttctc tcatttttcg gagagggtac gtgaccctgc 2086021 ttgataaaaa gaatgcgaaa aatgtggtca gcacaatcgc aattccagcg gcaagaaaaa 2086081 tatagcgggt cgtatgtttt gttgtatctt taacggcaag caaagactgg gataaaaaga 2086141 ccatgccttt ctttccgtct ttttcatacg ggacacctac aatcaggcgt tcattatccg 2086201 tgtctgtatc gctcagtccc gtccgtttgc ttactttttt atggtctttg agagctttat 2086261 ttaagtcttt gtcatgctgt atttgctcaa ccgtaataga cgacaggcga tttttatcat 2086321 tcggagaata ccagtggttc ttctcatcct ggatgatggc aatgcttgtt aagttatcag 2086381 cgagttccca agtgattgac cttgccagtg cctggtcctc gtgattttct aggatgacag 2086441 caactttatt cgcaagctgt gttaaatcat tctcagcttc ttccacatgg tagttttcaa 2086501 taaactccag caaaagaacc gttaaaatga acaatacgat caagacgagt gaaaggatcg 2086561 taaaccacag cttgcctact acgcttttcc aaaatttcat tcagcgccga cctcaaattt 2086621 ataacctaca ccccatacgg tgacaatttt tttcgcagct tccggagata ccttgttcag 2086681 cttctctctc aagcgtttga cgtgagtgtc cactgtccgt aaatcaccaa aaaactcata 2086741 ttgccacact tctttcagaa gcttttcccg atcatacacc ttgtcaggcg ttttcgctaa 2086801 gaaatataga agctcatact cttttggcgt caggctcact tctgttccat cagctgttac 2086861 gcggtgagca tcatggtcta ttgacagatg tgaaaacacg agcacatttt tcgtcggtgt 2086921 attggcattg aaataagagg tttgggatgc tcttctcaaa agggccttta cacgcagcac 2086981 gacttctctc gggctgaacg gcttaacaat ataatcatct gttcccgctt caaacccctg 2087041 cacccggttt gcttcttctc cttttgcggt cagcataata atgggtgtcg cttttttttc 2087101 acgaatttgc cggcacactt caattccatc agtccccggc atcatcagat caagcaaaat 2087161 taagtcataa ttggcttcaa gccctttggc aatggcttca tcaccatttt cagcttcatc 2087221 tatagcataa ttttcacgtt caagatacat tcttaaaagg cggcgaattc tggcttcgtc 2087281 atcaactact aatatttttg tttcgttcgt ttggtccatg ttttccccct gctttccttc 2087341 tgttactttc attttatcaa atcgtgagaa agtttgagaa ctgtgtcgct ttcaaaggac 2087401 tatgcataag aatgaagtcc ggcaagcaca agatttacga atattaaatt aaacataata 2087461 atagcaaaac cgattacggc cagccatgct gacttctcac cgtgccagcc tcttgacagt 2087521 cttaaatgca agtaagcggc atagaacaaa aatgtgatca gcgcccatac ttccttaggg 2087581 tcccagcccc aaaatctggt ccacgcgagc tgagcccaaa tcattgcaaa gatcagcgcg 2087641 ccgagtgtaa agatcggaaa tccgattgat acggccctgt acccaacctc atccaccaga 2087701 tcaagattga cgtttttcac cagcggatgt aatagagcgc tgattctttt tctgatgatc 2087761 agacggagag ccccatacaa cacaagacct gctccaaatg accaaatgac agtgttcact 2087821 tttctgcctg agaaaagcgc gggaagatca acaagcggtt ccattcttcc ttcggtcaaa 2087881 agctctccct gatgcggacc gacaagcgcg ggcatttcgt acaccatcac gcttttttct 2087941 ttacttttgt ccacccagtt aaactccgct tcatagcctg caagacgaaa tgccgatgtg 2088001 attgcaataa aggcgacggt tgtgaccagg ataaacataa tcgcttcaag ccagaaggtc 2088061 tttttgcttg gctttgtctg gtctacatgc ttcaaaagaa agatgacacc agcgacaaag 2088121 ctgatggcaa gtatagcttg cccaagcgcg gccgttgtta cgtgaatata cagccagtta 2088181 ctttggagcg aaggaattaa aggcgagata tctgtcggaa acatgctggc gtaggcaatc 2088241 agcaataaag caattgacag cgtaaacagg cctaatgaag gcaatctata gagaaaataa 2088301 agaatgataa acgccaaaac aagcatcatg ccaaaagcgg tggtgaattc aaacatattg 2088361 ctgacaggcg catggccgct tgcagcccac cttgtgatga aatatcctag gtggcagaaa 2088421 aaaccgacaa tagaaagggt gattccaatg ttggcccatc ggtttggcct gcccttttta 2088481 tctttattcc cgcgtatggc cccgccgaag attgggacag cgattaaata cacaagaaag 2088541 gccgcataaa gaaaatttcc gctcagctct gccatgacat cactcccttt tcgcctattt 2088601 ctgtgttttg attaattctt tttggtccac cggttcagtc agtccggaat cagccaatat 2088661 aaatgctaaa tccttcttca ggccaaacca gtttttattg gtatgccctg ctaccataac 2088721 tgcaccgtcc tgtgagtgca gccaaattct tcgatgctgc cagtacatac cttgaatgac 2088781 accgatcata aaaatggctc cgccgacagc aagcacccag agtgtcagat cctttctgac 2088841 tgtaagtcca gtaatgtttt tcgtttcgac atggtcaaat ttcagcttgt atttattatt 2088901 gcctgatcct tcgatggttt cttggatggc gacaaagctc ttttcgcctt tcggtttgtc 2088961 cggcgttatg atattaaaga caaaagccgg attgttaggg atctttgttt ttgtgctcgg 2089021 ctctccgtcc tgattaaaat agaagtcagg caggtagctg gcgatttcca ccttgtaacc 2089081 gttaccaaga tcatagactg aatctggatc cagaaggttg atcttcaggc tcccaaagga 2089141 tttttttgtt tttttatcaa tcagctggaa caccatttgg tcaagctgat tctctttgta 2089201 atccacctgg taaacggaaa aagaatcaaa acgcagcggc tgattgacac ggatgtcttc 2089261 ttctgttact ttttccagct tcggcttctc gccataaaca atttttcctt ctctcttgta 2089321 gagtacggca tcagtttgaa agttctttgc cactctaccg tccccgactc tgtcaatggc 2089381 atctgcaaat accttttttt ccgttttgct gttataggtc tctacgctga attgattgtt 2089441 tttcaaataa tattttccgt ctgtacccgg aattgctgcg gtttcgcctt ctctgaccca 2089501 aagcgtctca tcgacgtaca tgccaggcac aaatctcagc atcgcaccaa tcagaaagat 2089561 gatcaatcca atgtggttga catacgggcc ccagcgggaa aagcgtcctt tttcagcaag 2089621 aatgctgccc tctttttctc tgattctata atgttttttc tttaatagag taactatctt 2089681 ttctttcgat tccccgttca gtacagtaac tgtttcactg aacaagcgct gccttcttaa 2089741 aaaggccggg ctccttctga caccttggtt ttttaacgct ctatacaacg gaatgacccg 2089801 atcaaggctg caaatcacga gtgaaatgcc gatcgaggca atgagcagca aataccacca 2089861 agaaccatat aaatgatgaa acccgagcaa ataataaagc tggccaaacg tgccgtactg 2089921 ctccttgtaa taagtatcag cctgtgcgcc cggaggcaga taggcttcct ggggaaaaat 2089981 ggtgccgaac gctgatgcgg caagggttat gacgataagc catattccca ccttaaccga 2090041 ggaaaagaaa ttccaaattt tgtcgatgat cgttttgtta taggtttgcg aacgtcttgc 2090101 gcttccgtca tatctcatat cagcgagcgg aggttgagtt tcctgaagag ctcttccgca 2090161 cgattcgcat aaaacggttc cgaccgggtt tatatgtccg cattcacatt tgacttgctt 2090221 catcccgaag tctctccggg ttttatgaga ttcatataat cgtgtatcat gctttctgtc 2090281 atagtgccgg tcaccacctt gacaactttt ccttccggat tgatcaaaaa ggttgtcgga 2090341 agcggagata cgtcataggc atcaagcact tggcgatctg tatccagaac aaccgggaaa 2090401 ttgactccgt aggatttcat aaaattatgt actgctatct ttgactcccc aacatttaca 2090461 gcgacaattt caacaccttg gcttttaaaa tgcttatatt ggtttgccat ataaggaaac 2090521 tcttttttgc acggttcaca ccatgtaccc cagaaattca aaaaaacacc tttccctttt 2090581 aagtcactga gctcgatacg tttcccattc gtatcctcta ggacaaaatt cggtgcgtcg 2090641 gacccttcgg atatactctc tttgccggca aatacagcgt tgtaaatggt atagccgagt 2090701 gcgcagatta aaacgagaag gatgccggtc cgaatgaata aacgcctttt tttcttcatt 2090761 gtccactgcc cccttccccc tattgcagat ccattcaatt atatcattgc acgttcattt 2090821 cacatttctt actttttgaa ggttatgtga aatttagaaa gcgtttttac cgtgatccgc 2090881 cagtgctctg agccttttta cttcgtgagg cgtaagctct ctggcatcgc ccgtgtgcag 2090941 gcctcgcagg tttaaaaacg cgtattcctc acgcttcagc ttgattacct catgtccgat 2091001 cgcttcaaac atgcggcgca cttgtctgtt gcgtccctca tggatcgtca gctgaataat 2091061 gcttgtctgc tttttcttat ccaaagacag cagcttcgct ttagcaggcg ctgttttgcc 2091121 ttcctccagc ctaattccgc gctccagctt tctgagcagc tctttaggcg ggattccttt 2091181 caccttcgcc acgtatgttt tgtctatttc atacttagga tgcattagct tattggcgaa 2091241 ttcgccgtca ttggttaaaa gcaaaagacc gctcgtatca tagtccagac gcccaatcgg 2091301 ataaatgcgc tgcggaatat ttttaaaaaa gtccgtcacc actttgcgtc ctttatcatc 2091361 ttgcgctgcg gaaataacgc ctcttggttt atataagaga aagtaaaccg gctcttcgcg 2091421 ttcaaccttt aacccgttta cctcaatctg atcagaaccg gtgaccttaa cacctagctc 2091481 tgttactact ttgccattca cctttacttt tccttcttta atcagctctt ctgcctttct 2091541 gcgcgacgca actccggcat gagcaatcac tttttgcagt ctttccatgt ctttcacctc 2091601 aagtattatc ttactttttt caaccttaac aaacaagctt tttcaaattc ctatgccaaa 2091661 tctaaaaaaa acgccgtttt caggcgctcc caaataataa cgtaacgatg atgatagatg 2091721 caactacgcc gattaaatct gcaagaagtc ccacctttaa tgcatcaccc atttttttaa 2091781 tgccgactgc tccgaaatac acagtcagta cgtaaagcgt tgtatctgta gatccctgca 2091841 tgacggaagc cagcctgccg ataaaggaat cgggcccgta tactgcaatt aaatcggtcg 2091901 tcattccaag tgcggccgta ccggagatcg ggcggatcag agcaagcggc actacttcag 2091961 cagggatgcc gatagcggag aaagccggtt ttaaaagatc cattataaaa tcaagcgcgc 2092021 ctgatgatct gaaaacagtt atagcgacaa gcattccgac taaatagggg ataatggaaa 2092081 aggcaatttc tatcccctct ttcccgcctt cgacaaacga ttcatatgtc ggaacctttt 2092141 tgatcgttcc ataaagaaga attccggcaa taatgattgg aatcatggct aaagacagcc 2092201 agttgatgat ttccatccgc tcaccttccc ttctttttgc ggcggtaata aaaataccga 2092261 tcaatgataa tggcaccgat tccggaaata agcgttgcca aaatgcttgg cccgacgata 2092321 tctgtcggcg ttttggagga ataagccatt cggacagcga tcaccgttgt cgggatgagt 2092381 gtgatgcagg acgtattaac agctaaaaaa gtaatcatcg accggcttgc ttccgatcgg 2092441 tttccgttca gctttttcat ttgttccatt gctttaatgc caagcggagt tgctgcattt 2092501 ccgaggccga agaaattcgc cataagatta gataaaatat agcccatcgc cgggtgatcc 2092561 ggcggtatat cagggaacag tttagatata aaaggtctgc acatccggct gaaaatatcc 2092621 aaaagccctg actgctcggc gattttcatt aagccaagcc agaaaacaag cacgctcatc 2092681 aatccaaatg agatcgtaat cgcttctttc gcacccttaa acacggcttc atttacatct 2092741 tgcagagttc cgttgcacat cgcaaaaacg agtccgatca cggttaaact gacccaaatt 2092801 atattgacca ttttgctccg cctgccgcat tcagaaagat tgatttaaac gtttcaaaaa 2092861 attgtttctt cggtttttga tgccgctcat tttcataata gatcggcact tttgcgatgg 2092921 ttgcatcgtt gaacatgatc tccatgtgcc ctacgatgtc agggattttc gaggcatctt 2092981 tttcccatgc ttttttcggc ttgagcagtg tggtattaat ttttacattt tctttttcct 2093041 cttcggtcag caaataggtg atatcacgtt tgataaaagc cttcgattca taaaatgtgc 2093101 ctttcagctt tggaatatcc cctttttttg caattaaata ggtttgataa tgctcaaaca 2093161 catagttaaa catcttcata tggtcatccc aatcattagg gtcattaatg gtgacggcta 2093221 tcaggtcaat gccgtccttt gaagccgtag agaccagtgt ccgttttgca agttttgtat 2093281 agcctgtttt tcctcctgtg ctgtacggat aaagcatggt cagcagtttg tttttgtttt 2093341 tccatacgct ttccatcgtt tccgctttgt atatttttgt gcctgaaatc ttttgatagt 2093401 ctttcagctt catagcatac ttagttaaaa tggccatgtc ataggctgtt gaataatgat 2093461 tttcatggtc gtccaatccg tgcgggtttt gaaaacgggt gtttttcata ccaagctgct 2093521 cggctttttg attcatcata taaacaaacc catcgaggct cccaccgaca tgctcagcaa 2093581 tcgcgacagc ggcatcgttt cctgatctta gcatcaggcc atacacaaga tctttcagct 2093641 tcactttttg accttctgtt aaataaatgg cggagccttc tgttctgaca gcatttgccg 2093701 aaaccgtcac tgtttgatcc attttgccgg attcgatggc gaggacggcg gtcataattt 2093761 ttgtgatgct cgcgatccgc cttttttgat gctcatcctt ggcatataac actctgcctg 2093821 acgcaccgtc aataatgatc gcgctttttg cactgacatc tatagcagca tgtgctgtat 2093881 tcacatttac ggttgcaata agaaaagaaa tcatgatcac gaatactgct tttttgaaaa 2093941 tgcgcatgtt tgctcacgtc cttgtggtgg tttgtacaag tttatgcgca tgtccatcag 2094001 ttatgaataa caattatatt tctggaagca aacataaaaa aactctccct gaaaaaggga 2094061 gagtaaacgt tatctgattg gcgccatgct tgatccggac gcttcgtaat gagccagctc 2094121 ttccctcatc ttcagaaagg ccgcgctcaa cggcaataat aattgctcaa gcgacgcagg 2094181 aacagcatga taaaactcaa ttgcgctgac cccggtataa gacgcccggc tattttcaca 2094241 ccacgtgtct tttttcggca taaagaactc ttcaatgcat tggtgataca cattataaag 2094301 tgttttttcc gctctggctt cctgaaaagg ctcctgcatc aggagacgac ggcacgcttc 2094361 tgcgcctcct tcacaaaata ctgccattct tctcagagtg ctaagcacat cacagcagta 2094421 tcctttttca ataggcaatt cagcctgtaa ggactcaagc gtcgtttgat ttaggtaatc 2094481 gttcacggta ttgacaacca ttgataagaa ttcgcctgtt ttttgagtct gcgctcgcac 2094541 aatcgaatgt cccatttcgt ttggtatctt cccctcatgt atttgtctct cacattttgc 2094601 ttctttcatg atagcttctt ccttatatct tatgatgatg aaaaagcgcg attcattaaa 2094661 cttctatttt atatcttcga aggtttggtt aaagttttca aaaaataaat ctgcttcttc 2094721 ttgaagaacg tcttcttccg cattttcagg cagcggcgga agctcgtcca gcgttttcag 2094781 accgaattgt tcaagaaaag tcggcgtagt accgtataaa atggcccgcc ccggaccatc 2094841 ggcacgccct acttcacaca atagcgcctt cgcgacaaga ctgtgtaaaa tccgctctga 2094901 ttttactcct ctgatttctt caatttctgc tctcgtaatt ggctgtttgt atgaaacaat 2094961 ggccagtact tctaaagatg cttgagaaag gccctttgac ggcacttcaa tcagtttttt 2095021 caagtaaggc gcaaagtctt ttttggtaga gagcatgtac gtatctgcat actcaataag 2095081 ttcaatccct cgtgtatctc cgcggtattc gtccgccaca tccgccatga tcgtgttcag 2095141 ttcaggctct tcgatttcaa gcactgttaa cagctgcttt tttgtaagcc cttcatcgcc 2095201 tgccgcataa agaagggctt ccacaatagc tttccaattc acgatatcaa gccccatgaa 2095261 tggattcact ccccgtaatg taaatatctg aaaaattgtg ctcctgttca atgaggacca 2095321 gctgattttt catcagctca agaacagcta gaaaggtcac tactaaatgt tctttttgct 2095381 catatggaaa cagatccata aagttaattc tcgttcctct agatttcaag ctgtgcacga 2095441 tttcgttcat tctggcttcg attggtatgt cctgtcttgt aattgttgtt tccatcggcc 2095501 tgtttatttt tttgcgtttc agcacttttt gaaaagctcc gatcatatca tagaccgtga 2095561 cagagagctt ttgctcagac tgttttactt cttttgcata ttcactcaaa tcactcggcg 2095621 gtttcgtgaa cgatttttgt ctttcttctt cccgttcttt taaatccttc gccgcatctt 2095681 tatattttcg gtactcaatc agcttttcaa tcagttcctc ccgcggatct tcttcttcaa 2095741 gtaattcatc ttcaaaaagc tcctcctctt gcttcgggag cagcattctg cttttaatgc 2095801 tgagcagcgt ggcagccata accaaatact cgctggcaat gtcgagctca agcacgcgca 2095861 tcgtatgtac atataataaa tattgttcag tgatcttcgc cacaggtata tcatatatgt 2095921 caatttcaag acgattgatt aaatgaagca gcaggtccaa tgggccctca aacgtatcaa 2095981 ttttcacttg atattcttcc atcatctcac cattttcaag tatcactctc attgccggaa 2096041 aaactggcta ccctatagta taagccacca aaaagctctc gtccaatact atttcatatc 2096101 ctgttttgaa ggagtttgta cagaatattc aaaacacaag aggtgtttgc tcggagcgca 2096161 gaagcgggag aaaaagcctt tgcttctggt tttcctttct aagaagcact agaggccggg 2096221 cgttcttttt tccttttatc ccttctatgg tacactaaaa gcacattaaa ggaggaagca 2096281 ccttgtatcc gaaagcttat atagattatc tcgttgagtt tcatgcgaca cgggattatt 2096341 ttgaatgcca tgaaatatta gaagaatatt ggaaggaaga tccgccaaag aaacgaaaac 2096401 gctattgggt gggctttatt cagcttgcag tggctttata tcatcacaga aggcagaata 2096461 cagccggggc aaaaagactg atggcgaaca gcatccggat tcttcaagca gaacaccggg 2096521 cagtcgaaga cttagggctt gatcatggcc gtttgctcga acttatgcaa tcggtttacg 2096581 aacaaatcga aaccgtctct gcctataaaa gcattatact gccaatcaaa gatgagaaac 2096641 tggaggaagc atgcaggatc gaatgcagga aaaaaaagta tacatggggg cagcccagtg 2096701 cactcagcaa catatttctt atcgacaaac accgtttgcg ggatcggact gacgtcatcc 2096761 gtgaacgtga aaaagaaata gaacgcagaa aaaaaagcag agactgatca cagcctctgc 2096821 ttaattattg tatgaaatgt cttgatcctg ctgaccttga caacgttcga aaaagctctg 2096881 cgttaattca tttggaacca gtacttgcgt tttgaataaa tgctttaaag catccatcat 2096941 ctgttttccg attccttgat ggcgatgaga aggattcaca ctgatatgcc ggatctcaac 2097001 ctcagaatcc tttttttcga ctccgattgc tccgacgata tcctcgtcct ctttccaaag 2097061 aaagagctgg cggtctgtat ccgtttcgta gtccttaatt gtctgctgaa gctgcttaag 2097121 gtctttttca ttcggcataa acgaaagaag ccccatcgca atcttttcaa acgatttttt 2097181 ataacgaatt aacataaaaa cccctctata tccaaaatgt ccagtctgct attaacggat 2097241 acgaataggt gatccgtttt ctcacattat atcattttcg ccatattttt aaactgtttt 2097301 cagcaaatta ttcaaatgag cggtttaaat ttgccatttc aatggcagaa acagcacaat 2097361 ctacaccttt gttgcccgct tttgtgccgg cacgctcgat agcctgttcg atgttttcag 2097421 ttgttacaat tccaaagatg acaggtacac cagtagtgtt tgctgcttgc gcgatgcctt 2097481 ttgcagcttc attgcagaca taatcgtaat gtgtcgttgc gcctctgatg acagtgccca 2097541 atgtgataat agcatcatat ttttttgttt ccgccatttt tttcgcagca aacggtattt 2097601 caaatgcgcc tggaacccaa gccacatcaa tgtcatttgt gtctacgcca tgtctgagca 2097661 gcgcatcttc tgctccgctc agcagcttgc tcgtaataaa atcattaaat cttcctacta 2097721 cgattccgat tttaagacct gtaccaacta aatttccttg tatgatattc atatgattcc 2097781 catccttttt tgtgatattt gtgattagaa atgaagtaaa tgacctagct tgttcatttt 2097841 ggtttgcaaa tattttttat tgtgttcttt cgcctccatt tgaagcggca ctctttctga 2097901 aatactgagt ccgtagcctt caaggcctgc gatttttcgc ggattattcg tcaaaagctt 2097961 catattccgg acaccgaggt cgcgtaaaat ttgtgctccg atgccatagt tgcgaagatc 2098021 cggcaagaat ccaagcgcct cattggcttc tacggtgtca tagccttgtt cctgaagctt 2098081 ataagctttt aatttattga ttaaaccgat gcctcgtcct tcttggcgca agtacaggag 2098141 cactccacgg ccttctgcgg caatttggtt cagcgcggcg tgcagctgcg gtccgcaatc 2098201 acagcgatga gagccaaaca cgtcacctgt gagacattct gaatgcaccc ggaccaatac 2098261 cggttcttct ccgaacggca catctcccat cacaaatgcg acatgctctt ttccatctac 2098321 ctcatttgtg tatccataaa ccttaaatgt cccaaaatca gtaggcagcg taatgtcaac 2098381 ttcacgctcg acaagtgttg tcagattgta acggtattga atcaaatcct taatggtgat 2098441 catttttaat tgatgctttt tcgcaatttc aatgagctca ggcactctcg ccatcgttcc 2098501 gtcttcattc ataatttcac aaatgacgcc ggctcctgga gatccgcaag cttcagcaag 2098561 atcaacagca gcttctgtat ggcccgctct tttcaggaca cctccttttt tcgcaatcag 2098621 tggaaaaatg tgccccggac gctgaaaatc agatggcacg gatttgctgt ccagcaatgc 2098681 ttgaacggta aaagatcttt cttgagcgct gatacctgtc ttcgtttcac gatggtctat 2098741 gcttacggta aatgcagtgt ggtgagagtc tgtattatgc tcaaccatag ggtgaagatc 2098801 aagcctgtct gcgatttcct cactgagcgg cgtgcagatc agtcctctcc catgtgtcgc 2098861 cataaagtta atgacttccg gcgttgcatg ctcggcaaga gccacaaagt ctccttcatt 2098921 ttctctgtct tcatcatcta caacgatgat gacttcgcct ttttttaaag cgtccagtgc 2098981 ttcttctatc ggatgaaaca tgcaaatctt cctctctaaa agccgttttc gcttaagaag 2099041 gcttttgtaa tggtttgttg ggtcttattt tcattggctt tatgcaaaaa tcgatacata 2099101 tattttccga tcatatcgca ttcgatattc actttagagc cgatcgtttt ttctgaaaag 2099161 atcgtttcgc tgatcgtatg cggtattaag gagatcgtca ctgtgtcttc tgtcaggccg 2099221 aatatggtta agctcacgcc atccacagta attgatccct ttaaaaccaa tgtttttgtt 2099281 aatgacgggt ccatttttaa atcatagtaa actgcgttgc ttttctcttc aattcgtgtg 2099341 atttccgcag ttccgtcgac atggcctgag acgaaatggc ctccgaaacg gccgtttgcc 2099401 gccatcgctc tttccagatt tactttgctt ccttttgtta aatcattcag tgacgtagct 2099461 ttgactgttt caggcataac atccactgtg aattgatttt ttgtaaaatc agtgacagtc 2099521 agacaaatgc cgttcactgc aatgctgtcg ccaagatgaa catcctctaa aatctttgag 2099581 catttaatag ttaaggccat tgcatgccct gcttttttca tggattcgat tgtgcctgtt 2099641 tcttcgataa ttcctgtaaa catggtcacc atcctattcc tttgtcggtt ttgccgtcag 2099701 tttgatatca cggccgattt gggttatatc agtgaattgt aataagggga catctttcat 2099761 tgattgaaaa ccttcaccgg agattaagct gggagcatgc gttcctccga ttagtttagg 2099821 ggcaaaatag aagatgattt cttgaaaaca gccttctttg acaaagcttc cgtgaacagc 2099881 tgaaccgcct tccacataca ccgacatgat gccttcttcc gctaggatct tcaaaacatc 2099941 aggaatttga atgcgctcgg tttcaagtgt aaatatgttc actccgaaag ctgaaagccg 2100001 ttttttcttt tcctcgtctg cgcgtgccgt cgtaaaaatc catgtcggcg ctatttgatc 2100061 gcaaatcact ttagcgtcct caggaatcga gagtacggta tcaagtatga cccgaaccgg 2100121 ctgttttgtt acattcggca gtctgcaggt taagctcgga ttgtcggctt tcactgtgcc 2100181 aactccgact aaaatgcttt ggtgtgtttt cctgtattgc tgagcatcct gtcttgcagc 2100241 ctctgacgtg atccatttgc tgtcacccgt gctggtagct atcttgccgt caaggctggc 2100301 agccgctttt agcgtgacgt acggaaggcc tgtcctcata aagtgcagaa atttttcatt 2100361 cagcctctcc gcctggtctg ccaggatgcc ttcccttacc tcaatgccag cttctttcat 2100421 catgctgatc cctcttccag ccacaagcgg attaggatct ctcatcgcca cgaacactct 2100481 tttgatacca gagttgataa tcaattctgc acatggcggt gtttttccgt aatggctgca 2100541 cggttcgagt gtaacgtaaa tgtcggcacc ctctgcatgt gctccagcca tatggatggc 2100601 atgaacttct gcatgagctt caccatattt taaatgggcg cccattccga caatttgtcc 2100661 gtcctttacg acaacagcgc cgacgagcgg attggattcg gtctgtcctt cgccctgctt 2100721 cgcaagatct aaggccagct tcatataata ctcttccatt tgtttccctc ccctcttttg 2100781 ttatttaccg tcaaaaaagc cccgaattta taaaaaattc ggggctttag gtattttacg 2100841 caataggaaa taacactatg catttttaaa cattttgcat agcggctcat catccttctc 2100901 ccatccagac tttcactgtc ggcttcagct taaactgaat ccaccgcgtg cttatgcaca 2100961 cgggtcacgg gctctaaagc aaatgtgctt tactaccgcc ggtcgggatt tccaccctgc 2101021 cccgaaggat acaatcttta ttcatttgtc cttattggtt attatagcga tcctttttaa 2101081 agtacgcaat gaaataaact tacaatttga gaaaaacaaa acatcaccct tcgatccgaa 2101141 aggtgatgtt ttttaatcat tcacttttgc aaccttgatt aatccgtcga tccgctttga 2101201 tttgctgaag taagccttaa tcttgtcacc ttcttttata tcagataaat cctgatttaa 2101261 tttttttccg ttgaagatga ttttcgttcc gttttctgct actccatgat actctgagcc 2101321 gtcaattttc gtcactttat attcctggat ggtgtattcc tcttcttccg aggacaaggt 2101381 ttgtccaatt gctgtcggaa catccttcag ctcaatatca tttatgtaca tataaccgcc 2101441 tgcaagtaaa agcaaaagca ctaacagaat ggtaatcttg gtttttattc ttcccatttc 2101501 taaacctcca gccaatatga atctattcat tcatatgagt tattcctttt tttcatgaat 2101561 aaaaaaccgt aaattctcgt aaattattaa tataacgatg cataacggga atatgtttca 2101621 catttctgca aaaatttctt ttctatagat atacgaattt atgttctgtt tttaggggat 2101681 gaccgtaaaa aagatataaa aaaagcagcc ccaatgggaa gctgcttgat cctaatttgt 2101741 tttgcgcatt tcgttaaacg ggtagaaaac aaactttgac gtacccgcaa tttgtttttt 2101801 cgtgaagagg ccaaggccgt tacggctgtc catggaattg cgacgattgt cacccatcac 2101861 aaaatacttg ttatcaggca ctttaaccgg gccgaaatca tcggtcaaat ggtcaaaacc 2101921 gtcctgtttc gctctctttt tattagccgc caaataaggt tcgtccacct ttttcccgtt 2101981 gatatagagc tggtcatttt tcatctcaac cgtatcgccg ggaaggccga taatacgttt 2102041 gacatagtga acatcatctc cgtttaacac gacgatgtct cctctatcaa actcgccgat 2102101 gtatttgact gtcatattaa caaaaaccct ttcacggttg tgaagtgtag gatacataga 2102161 gtcaccatca acgacatacg gcgcaaaaat aaagttgcgg atgagcaaag caagaacgac 2102221 agcaatcaca attgcttttg cccattctaa tattgacttt ttcttcgaaa cattttctga 2102281 tttcaactga tttcctccaa taaacaacgg tcttcaattt atgttatcac gaatcgaaaa 2102341 aaaatcccat taggaccatt gaagtgattt tacaaactgt taatcttcat cttctaccca 2102401 catcatgcct attttttctt gtcgatcata actaggcctg aaaatattga aagaaatgaa 2102461 tcgcataatt cagaagcgat ggactcagaa gaaagagagt tctcatatgc aaaatcttta 2102521 gatcgtatat aaagcatgag gttacgggca gtttgttcat ttactgcatt ccattgatct 2102581 cccagtccat gatacccatg gcacttgaca aaacaattaa cgtcatgaag gttactggaa 2102641 tgtttgcggc aacctatttc acaggtgata accgcacccc gttttttgct ttcataatat 2102701 gtttaaaatc attcaagctc gaaaacatgg atcagcctcc aaaaaataaa tccaatatat 2102761 tcccggcagt tgaagactct ttattataaa actctgaata tccgcagttc ttacagtaaa 2102821 ccactagaaa tcggttatgc tgcacgtcaa acagctttga taatcccgtg ccggttgtag 2102881 ctatttcttt ttgtccggct tcagtactac cgcattttat acagcctttg ttgttcatat 2102941 cgcgatctcc ttttcattac atcacgtttg tttgatttat tttactacaa aatatcaatc 2103001 ccaatgaccc gtactacttt aaagtttact taattttgat tacatactaa ttgggttcgt 2103061 ttctcagctt ggtaaatctt ctggagaaac ggaaaagctc catgaccaaa acattcaaac 2103121 tcagccaaac accgccgaag gcgtaacccg cagcaacatc actcggatac tgctcataaa 2103181 gtacacacgg ctcagcccga tgaggaataa aacgataata aacaaaaaaa tgcaacagtt 2103241 tgcagacgcg tcttgtgaga atgacgaaca aaaagataag cacaaaaacc aaaaatgaca 2103301 aatgccgtta aagtctgttc gctcgggaat ggatataata catgactttc caaaggagcg 2103361 tgaacaggat gaagggaatg aaagagccgt ctgattccct cttcataaag ctccccacca 2103421 atgactagga aaaataagaa agagagttcg attttccgat cttgccctct gaataccgtc 2103481 caaaaaaaag ttagaacaat aacggctaac agaacacctc tcgacgcaaa agctttctga 2103541 attgcagctg ggcccagtct atacccgatc caatacgaca tgctcactcc cacagctccc 2103601 caatccggcc gctaacatgc ttagcaccca gtttaacttt tcttgaaaca cgagaacacc 2103661 ggcaaactct cccggtccaa gtaaagctag aagctctaac atcaagacaa taaacaagac 2103721 ggcatatccg tactgttcga gcaaccccgt caaaacttgc atgtgattct ccttaaactt 2103781 ttttgttctt ttatcattcc caatccactt tttgtataat cagcacaatt ttatcttcag 2103841 tcgtccaaca acattgtcta tggcgggatc ttctctcata cattcttttt tgacatagga 2103901 ggagcaatag catgaaatgg gaggaaacaa aagatacgca gggagtttgc caaaattttg 2103961 ggcagttcgt tctgccaccg agtcaggtgt ttgtttgccc acctcatccc ttgtcaattc 2104021 cccatttttc ccgtttgagg ttcgaaatgg taaagtattt cacttagttt cttacatgaa 2104081 gaggtaaatt ctttgctcac cgaactagga tagcggcgta tggcgatttc tacattgcat 2104141 aaccactggt tatttagtga gccgtgagca atgtatatgc actttgagtc agcacaggat 2104201 gatcctatta cattcgccag aaaagcagct gccgcattca gagtagttaa aagaatagac 2104261 agatatctgg gcttccggaa gctttaaagg aggctctttt ttcgagcatt tttataaatc 2104321 aataaaaaca ggcatctcct aaatattttt gccgataagt ttacgctaat caactctagc 2104381 actaatacat ataaaaaata gaatgatatg aaaggagact tgatagtatg attgattatc 2104441 ctattaatat aaacaacgtt tccgggaaca gtgtaattaa cgtaggcggc gcttttatga 2104501 tcaggccttt aactttgtcc aaatctgtgt ttggctccgg aggtttaaac acaggaattg 2104561 tctttgaaaa taactttgta agcaaagcta aaatgattaa tcatcaattt actgatcaaa 2104621 acgtcaccaa aactttttaa tgtattcaat acacgggggt cactaactaa acacctggtt 2104681 ttgccaaccg ccatcagcat tcggcggttt tttattgaac atttttggcc aataaaaaaa 2104741 gcttcctctc taagaggaag ccttttgcct gccgattagc cttctacacg aacttctttc 2104801 atgacatcgc cattagacat gtttttcgcg aattctaatc cgcttgttac tttaccaaat 2104861 acagtgtgaa caccgttcaa atgaggctgt ggctcatgaa cgatgaaaaa ttggctgccg 2104921 ccagtgtctt ttccggcatg tgccatagaa agtgcgcccg cctcatgtgt atgcgggttg 2104981 ccttctgttt cacatttgat tgtgtatccc ggaccgcctg taccagttcc gtgcgggcat 2105041 ccgccttggc tgacgaagcc agggatcact cggtggaatg taagcccgtc ataaaagcct 2105101 tcgttcgcaa gcttttcaaa gtttgcaaca gttccaggtg cagcttcagg ataaagttca 2105161 aattcaattt tgttcccgtc ttctaataaa aagtaacctg ttttcaattg tatgcctact 2105221 ttctttattt taattttcaa aggagattat gtataggtta tagcctgtct ctccttgtcg 2105281 cggctattat accacacctt tcgggggaaa acgaatctcc cgagctttac taaaaaataa 2105341 aaatgaaacc tgaatctctt tatctccgtc taacctaacg gaactgtatt tttcatgatt 2105401 caggtcctca caaagcagca ctatccagct gcttgtgaaa ttgaaggagg tcaaactgct 2105461 ttgaagaaaa tttggattgg aatgctggca gcggccgttt tgctgctgat ggttccgaag 2105521 gtcagtctcg cggatgccgc agttggagat gtcattgtaa cactgggtgc tgatttgtca 2105581 gaatctgaca aacaaaaagt gcttgatgaa atgaatgtcc ctgataatgc cacaacggta 2105641 accgtgacca ataaggaaga acatgaatat ttaggaaaat atatatcgaa cgcgcaaatc 2105701 ggatcgagag cgatttcttc atcgtcaatc accattgcca aaaaaggctc cggattgaat 2105761 gttgagaccc ataatatcag cggcatcaca gatgaaatgt acctgaatgc actgatgaca 2105821 gccggtgtta aagatgcgaa ggtgtatgtt acagcaccgt ttgaagtatc cgggactgcc 2105881 gctttaactg gattgattaa ggcgtatgaa gtttcttctg acgaagcgat ctcggaggat 2105941 gttaagcagg tcgccaacca agagcttgtc acgacatcag agcttggaga caaaatcggt 2106001 aacgaaaatg cggcagccct gattgcaaaa atcaaagaag agtttgctaa aaacggggtg 2106061 cctgataata aagctgacat cgaaaaacaa gtggatgacg cagcttctga tttaaacgtc 2106121 acacttacag acagccaaaa gaatcagctt gtctccctat tcaataagat gaaaaacgct 2106181 gacattgact ggggacaggt cagtgaccag ctagataaag cgaaagataa gattacgaaa 2106241 ttcatagaat cagatgaagg caaaaacttc atccagaaag tcattgattt cttcgtatct 2106301 atctggaatg cgattgtatc tatattcaaa taagaaaagc gccgaaaaat cggcgctttc 2106361 ttttattgct ttacacccgt tttaaatggc agatcaagtt ttacaatatc ttcgtatgtt 2106421 tctcgcttca cgactaaatg agcctcaccg ttttcgacaa atacaacggc gggtctcgga 2106481 atacggttat aattgttggc catgctgtat ccataagcgc ctgtacaaaa aacggcaaga 2106541 agatcgcctt cttttacttc cggcaggtca atatcccaaa tcagcatatc tccgctttca 2106601 cagcactttc cggcaattga taccgttttg tcatgcgctt ctccgatcct gttggctgcc 2106661 gcagcttcat atttagcttg gtaaagcgca ggacgaatat tgtcgttcat gcctccgtct 2106721 acagccacat attggcggac acccggcact tctttttgag agccaaccgt ataaagagtt 2106781 gtgcctgcgt ctcccacgag agaacggccc ggttcgatcc aaatttccgg aatgtcaaaa 2106841 ccgtaacggg aagcattttc tttcacagct tcgataattt tttcaacgta ttcagtggca 2106901 tgaagcggtt catcatcttc cgtataacga atgccgaaac ctcctccaag attcagcacc 2106961 ttggatacaa atgaatatga atctctccat tcgtctagtt ttttgaagat tttttccgct 2107021 gctaacacaa aaccggccgt atcaaagatt tgcgagccga tatggcaatg gacacccagc 2107081 agctgaatgt gttccgattg taatacttgt tcaatggccc gttcagtttg tccgttatga 2107141 agatcgaaac caaactttga atcttcctgg cccgttgtaa tgtagtcatg cgtatgcgct 2107201 tctactccgg gcgtgatccg aagaagaaca tcgatggagt gacccgtttc tttacatagg 2107261 tcttcaagaa gcgcgatttc atagaaatta tccaccacaa tgcagccgat gcggtgctca 2107321 agcgccatcc gcagttcttc cctgctctta ttgtttccat gaaagtggat gcgttctgcc 2107381 ggaaagcctg ctgcaacagc cgtatatagc tctcctccgg atacgacatc taaagaaagt 2107441 ccctcttcct cagcgagctg aatcattgcg actgatgaga atgctttgct cgcatatgcc 2107501 acctgtgctt tcagccctgc agaaataaac gcctgcttaa agcttttagc acgctcacgt 2107561 attaaagcca catcatatac gtaaagaggt gtaccatatt tctccgctaa atagagagca 2107621 tccacacctc cgatttctaa atgaccatgt tgattttgtc tgcttgtgcc gtgtaagaac 2107681 aatgtcattc cctctttctc cgcttatgga tgaaaggaca gttttatgga ctgtcccttc 2107741 ataattaaga catacattat catactcttc agtcagtttc aatgcgatta tgaattggta 2107801 ggctgcctta agcgattttt ggggtgaacg atgctgggtc ttacttttgc gccaggtttc 2107861 gctgtgcgga caagaacctg ccacagcgcc tttccgttaa agggaatcag cggccataag 2107921 tacggtgtct gaagggattt gatgcttgcc atggcaataa ttagcactgt aaatccgatg 2107981 acgagccctt ttatatgaaa taaagcaacg agtatcatga ggacaagacg gctcattttg 2108041 tttgccaagc ttaattcata actaggcgtc gtaaaggttc caatcgccgc aagtgagacg 2108101 tacagaatca cctcaggaga aaaaaggccg acctcaatcg caatctgccc gatcagaaca 2108161 gcggcaatta aacccattgc tgtcgataaa gccgtcggtg tgtgaatggc agccattctg 2108221 agaaactcga ttcctaagtc agctaaaaat atctgcagga tgatcgggat atgcgtatct 2108281 ttatttaaac cgataaattt catgttgtcc gggagcagat caggctgaag cacaaagaga 2108341 aaccagatcg gaagaaataa agtagaagca agaataccga aaaatcttac ccatcttaaa 2108401 aaggtcccga ctgaaggcgc ctgcctatat tcttcagcat gctgcacatg gtgaaataaa 2108461 gtcgtcgggg taatgatcac actcggcgat gtgtccacta taatgataac atggccttct 2108521 agaacatgat ttgcggccac atccggtctt tctgtatagc gcacgagcgg aaaaggatta 2108581 tagctttgat taacaatgaa ttcctcgaca gttttgtctg ccattgttaa tccatcgaca 2108641 tcaatggatg caatttcttt ttctacgatc tcaaccagat ccggatcagc tatatcttct 2108701 atataacaaa tgcttaaatc cgtctttgac cgctcaccaa ctttagtcat cttgactcga 2108761 aggcgttcgt ctctgatccg ccttctgaga agggccgtat tgacgacgat attttcaaca 2108821 aatccgtctc tggctcccct gaccaccttt tccgtatcag gttcttccgg gtttctgccc 2108881 ggatagcttc tgacatcaat tataaatgcg aagcctgcac cttcaacaat gacagcgacg 2108941 agcccggaca gcacttggtc ggtggtttca tccaaggttt ttactttttc gacctgggcg 2109001 ttaagcagcc tgttttcgac gatgtcgacc agctcatcag ggtcttcttt ccgattgtta 2109061 atggcaacaa gctctctcat taaatgaata atataggctg tatcgcataa tccatttaga 2109121 tagtaaagct ggatctcttt atctaaaatc gtgagcttgc gaacacctac atcatagctc 2109181 gtccccatcc caacacggtt tttgaaatac tcttcatttt tagctggatt ccgataaacc 2109241 cgaattttct cttccttgtg gtccggcatg atacccgctc ctttctaaaa taaactcgac 2109301 cgctttcatg gtgattggcg acccttttga gatatcgtct tttctgccca ttttgccgat 2109361 atccccgata ccgacaataa gcgggagatc aagtttatca aggcaataga ctgtatctcc 2109421 actcattctg tggtcatcaa attccctttc cccgacttta tcgacgccgt attcagttat 2109481 ttctccattg cggtcaatgc ttacatcgac cctggtccat tcagcctgat gtgtttttga 2109541 cgcgaccgca atcacaccga gcacttcaat agacggatgg gttgcgacat aggttagagc 2109601 ggcttctccc gggccctctc cttgaaggcc ggagtcgtca aacatgacaa atacaggatc 2109661 atacggtgct gaggcgatca gcttgacaag ctcggcgccg ctgcgggtgg aaggattccc 2109721 ttttgattgt gaaatacatc ggcctcccac tttgcttgcg gcgtattcaa ttgttttagc 2109781 ggcataaaca tccccgtctg ttaccagtat gaccttgcgt tttgtcgtca tgtcggcatt 2109841 atcctttcgg tttgaaaata acagctacga taaaggcgaa aagaatagcg gctgagatac 2109901 cggccgaggt cagctcaaaa atccccatgc cgattccgat aaatccgtgt atatgcgcct 2109961 gatgcatggc gccgtgcaga agactgtgac cgaagctgac gatcggaacg gtggcgcctc 2110021 ctccggcaaa ttcaataaat ttatcgtaaa tgccgaaacc atctaatatt gcaccgatta 2110081 caacaaatga tgtcatgaca tgagctggcg tcaatttaaa aatatccaag agcagctggc 2110141 cgacgataca gatggccccg ccgcagacaa aagccaaaag gtagtccata ttaagatgca 2110201 cctcctgcac gctcaaatac aaccccgtgg gcgatagtcg ggatggtttc tttttgctgg 2110261 atcatcgtcg ggcttaatag cgccccggtc gccacgacaa atacacggtt tagttttcct 2110321 tctctcagct gcttaaaaat atgagagtag gtgacaaccg ctgaacaagc acagccgctc 2110381 cccccggcaa agacctgctg atccggagtg taaatcagaa gcccgcaatc atcatgcttt 2110441 gtgccgactg gatatccatc ttcttttaaa atgtctttta cgattggaga accgacgcct 2110501 gacaggtcac ctgtcaggat tagatcatag tcatccgctg tccggttgag atctttaaag 2110561 tgctgcttaa tcgtatcagc tgcagccgga gccatagccg atcccatatc aaaaggatct 2110621 gtaattccta aatcagaaac cttcccgaca gtcgcacttg tgatttggat atcacccggt 2110681 gtctgactga tgacaactgc accgcttccg gttacagtgg aggtagcagt gtccggtttt 2110741 tggcctccgt attctgtcgg atagcgaaac tgtctttccg cagttgcatt gtgactgctg 2110801 gtggcagcga gtgccctttt ggcaaaccct ccatcaacta aggctgatgc gacagccact 2110861 gtttccattg atgttgaaca ggcgccaaac atacaaagaa atgggatttt caagtgtctt 2110921 gccacatagt tagccgtcac gttttggttc agcaagtcgc ctgccagcaa taggtcaata 2110981 tcatcttttg tcagattgtt tttttgaagt gcaacattaa cagcgtcttc catcagctgc 2111041 cgttccgcca tttcccagct tttttgatta caatgcattt cgtcataggt tttatcaaat 2111101 aaagagccaa gcggtccgtc tttttccttt ggtcctgctg ccgttcccgc tgagttgaca 2111161 aatatgggat gttcaaatac ccaggtttgc tttcctgtta atttcatttt cttctcctcc 2111221 tatgacatca gtttctcaaa agcaaaccga atcattccaa cgatgtatgc agctacaact 2111281 ccgaaaacaa taacatttcc tgccagttta aacatatttg tcgctactcc aagcactaat 2111341 ccttcgcttt tatattcaag agccgcactt gccatactgt tggcaaaacc cgtgacaggt 2111401 acggctgaac ctgcgcctgc gaattgtccg attctgtcat agattccaaa ccctgtaagc 2111461 agggcagaaa ttaatatcag cgttgcagct gttggattcc ccgcagtttt ttcattgaaa 2111521 tcaaaaaaat ggatataaaa attttgcaga ccttgcccga ttgcacaaat cagtccgccc 2111581 actaaaaagg cttttacaca gttccagacg taaggcggct taggctgata tgttttcact 2111641 tttgatttgt aattttcttt tatgtttgtc atcttgaaac ctccttatga atggtcaata 2111701 aagtacagcc agtgaaataa agatcccgcg attttcccaa tcacgatggc cattaacaga 2111761 ataatgattt tacttctgag cccgattcgt ttcgccaaaa tcggcaggac atttaaaacc 2111821 tctgtaagag cagccgctag catcccgacg aacaaacctg ccagaagccc gaccggcaca 2111881 gctatccatt ttgttagata aagatgattc atatgaagcg tctcccatcc cccgcaaacc 2111941 gcgccaagaa taacagccgc ttcataagcc tgaacaaatc tcattgtttt ggtgagctgc 2112001 atcagccgcg gaatgattcc cattacggtt aaaaaagcaa cgaaacccgc ccccaccgtt 2112061 atgcctccgc cgagcccgac aaaaatgatg aacaatacac taacgatcat gcagatcctt 2112121 tatggtttct tgattctcat gcatggccac atattgatcg agatcaagct gatagttaaa 2112181 catctcaacc tccagcgggc tgggctcttc atttaggcgc tttttaaata tgtggttaaa 2112241 aaacacgatc atccccagtc ccaaaccgat gctgtatggg atttgaagca aatatggata 2112301 gtcattcctc tctccggtta tgatttcata tagtgcgata tgaacatctc tcatgcttac 2112361 atcctcatga aagttcatga tggcaagaca cgatccaata aacagaagca gccagacacc 2112421 gataaataga accgttgata aatttcgctt tcgatactga atttcaacaa tggtttctgc 2112481 tccgcctacg gtttgaacat caattgtcgg gtcttgtaaa tgaatggctc tgaggacttg 2112541 tatgatatcc agaattacga tatttttatc tttttcgctc acctgataaa gcggcatagc 2112601 cgaaagtttc tttttcagct gaagctgccc ttctatttgc gcggcatctc caacggtaat 2112661 aatatcccct ggatgtgcca gcactcggtg gcgaagccgg ataaatattc gtcgttccat 2112721 cattgatcac catctttcgg tggttatata tgtagtatgt ggttcgattt tgttctcatt 2112781 catccgctcg aaaagaccat aaattaccac gcttttgcac aaaaaagcta gcctgcactg 2112841 cagactagcc atccgtatga tccatttgaa ccttgatctg ttttaatatt ttcttttcaa 2112901 gcctggaaac ctgcacctga gagatcccga gccgctcagc cacctcggac tgtgtctggt 2112961 ctttataata tctgagatag acgattagtt tttccctttc ctccaaatcg ctgatcgctt 2113021 ctttcagcgc aattttgtca aaccattttt cttctgagtt gtcagcgatt tgatcaagca 2113081 gggtaatcgg atctccgtca ttttcataaa cggtttcgtg aatcgaagat ggagccctta 2113141 ccgcctcttg ggccagtaca acatcctcag cttcaatctc caaatggtca gcgatctcct 2113201 gcaccgtcgg cactctgccc agtgttttcg aaagctcatc cttcgcgcgc cggattttgt 2113261 ttccaagctc ttttaatgac cgtgatacct ttacggttcc gtcatcacgg ataaatcgtt 2113321 ggatttctcc gataatcatc ggcactgcat acgttgaaaa acgcacatca taggttaaat 2113381 caaatttgtc aacagatttt aacagcccga tgcagccgat ctggaagaga tcgtcaggct 2113441 catatcctct gtttaaaaac cgctgtacga cagaccaaac aagacgcatg tttttttcta 2113501 tgaggaggtc tcttgcctgc tggtcgccat tttggctttg tttgattaat tcctttactt 2113561 catgatcctt cagctgagcg tttttgccgt ttttcttaac ctccacatcc ataacaaatc 2113621 tccttaatta caaagcgctt tgctttttga taagtgcttt gttaagcgaa tcgttgttcc 2113681 catttcaggc gatgaatcga tactgacatc atccatgaaa ttttccataa tggtaaagcc 2113741 cattccagag cgctcaagct caggcttagt cgtaaataga ggctgacggg cttcttcaag 2113801 atctgtaatg cctaagcctt catcacgaat agtcatatat acgacatgat cttccagcgt 2113861 cactgaaatg taaactttcc cttcacagtt ctcttcatat ccatggataa tcgcattcgt 2113921 gacagcctct gacacgactg ttttgatttc agtcagttca tccattgtcg ggtccagctg 2113981 agctataaat gaagcaactg tcacacgggc gaacgattca ttctgactga gggcagaaaa 2114041 ctcaaggtgc atttcatttt tcatgatgcc acccccagtg tcaggagtgc ctgctgttca 2114101 gattgttcaa atcggataat tttaaacaga cccgacatat caaacaatcg cttcaccgca 2114161 ggagagatag cgcaaacaac catttctccg ccaatttgct taatttgctt gtatcttcct 2114221 aaaataacgc caagccccga gctgtccata aaggaaaggt cctccaagtt cagcacgata 2114281 tggcgaatat catccttctc caatgattga gtcacttttt gcttcagggt ttcagccgta 2114341 tggtgatcga gttcgcctgt taatcgaata caaagcacag attctttgac attcatgtca 2114401 attccaaggc tcatgctcat tcctccttga tatgatcgga taatgagtgt ttcgatttcg 2114461 acggaatgaa ttccttcacc gtgacaaaac tagtggtcat tcggcataat tacttaaatt 2114521 ttgtccagtc tcccatcgtc cgctttaaga atgtgataaa cccggctttc ttcatatctt 2114581 cttttgcagc aacaggactt tcagcgagta cttctccatc ctttttcaga acaagagtgc 2114641 caagctcttg gcctttttga atcggagcac taatattgtc cttcatcttg atttcttttt 2114701 tcacatcgtt catatcctcg ccttttttcg tcaatattga aatcggctca gatgtagtga 2114761 gttcgataaa tttttgtttc ccttttttga cctttacttt tgctactgtt tgatttcgtt 2114821 tatataaagg atgcgtttca tattggctaa aggcgaagtc aagcattttt gtcacttgcg 2114881 cgtttctttc tttaggcgtg ctcgctccga atacaaccgc tatggcccgc atgtttcctt 2114941 ttttagccga agcagtcaga caatatttcg cttcgcctgt atagcctgtt tttacgccgt 2115001 ctacaccagg ataaaatttg ataaggcgat ttgtatttac aagccaaaac tttttatctg 2115061 tattttcacg cagataatct tcatacgtgc cggtaaactt cgtaattgat tcgtatttca 2115121 ataattcctt agccatgatt gccatgtcat aagcagagct gtagtgtcct tcctcggtca 2115181 gtcctgttgg gtttttaaag gatgtatttt tcaatcccag ctcttttgct tttttattca 2115241 ttttcttcac aaattcttct tcagagccgg aaataaattc agccatggcg acggaagcgt 2115301 catttcccga agcgattgcg atgcctttca gcatttcttt gacagtcatt tcttcgccgg 2115361 gctcaaggaa tatctgtgag ccgcccattg acgccgcatg ctcgcttgta cggaccttat 2115421 cactcatttt gattttgcct ttatctaaag cttccataat caaaagcatc gtcataattt 2115481 tcgtcatgct tgcaggcgcc agtctctcat tgctgttctt gttgtaaagc acttttcccg 2115541 tgtcacgttc tatcagcacc gcagacttcg cttcatgagc aagctccgat gtacgttttc 2115601 cgtcttgttt tgcaaatgca gacggtgcaa atgtaagcag cattatacca atcaacaaag 2115661 tggataaaag acgtttcatc tcaaaagccc tccatttcat aatccttttt attttttcca 2115721 agcgtgatgg ttttatacgc cactgatgga aaatgtttcg aattttgggc ataaaaaaag 2115781 acagctgtgt gatatcagac acagctgtct tttggtcctg cattgattca tatttattcg 2115841 tactgagcga cgatcgcttt aacaagcttt aagaatccag cttttacttt ttcggtcact 2115901 tccataactt catcgtgact taaaggctga tccagaattc cggctgccgc gttagagatg 2115961 caggaaatgc caagaacccg cattcccgca tgattcgcta caatgacttc cggaacagta 2116021 gacatgccga ctgcatcaga gcccatcgtt cttaagaaac ggacttctgc cggtgtttcg 2116081 taagaaggtc ctgtcacagc agtgtacacg cctttttgaa ttgggatatt aaggtctttc 2116141 gcaatctttt cagccaggct ggacagatct ttgtcatagg ctgaagacat atctggaaat 2116201 ctggcgccga aatctgcttc gtttggcccg attaacgggt ttgttcccat aaagttgata 2116261 tgatcggtaa taatcattaa atctcccgca cggaattcag tgttgacacc gcctgcggca 2116321 tttgtcacga tcaacgcttc cacaccgagc gctttcatca cgcgtacagg gaatgtgact 2116381 ttctccattg agtagccttc ataaaaatga aagcggccct gcattgcaat gacggaaact 2116441 ccttcaagag tgccaagcac aagctgtccg gcatgccctt caacagtaga taccgggaat 2116501 tcaggtatat cttcatattt cagcttgacc ggattttcga tttcgtccgc caaaatgcca 2116561 agacctgagc ctaaaataag gccgatcttt ggagattccg gcaggttttg tttaataaaa 2116621 gcggctgcgc gttcaattct gtccttcaag aaacagtccc cctattgtaa taaagataaa 2116681 aagcttttcc cgtatttcgg tttatttgtt tggaaattat cagcgatcgt tgcgccaata 2116741 tcggcaaatg tatctgcaag cggcagcatt tgcgctttct tatgtttttt gctgtaagcg 2116801 agaatcggca catactcgcg tgtatggtca gtcccatgat gaatcggatc attgccgtgg 2116861 tcggctgtaa taattaacag atcgtcttct ctcatttttt caaacacttc cggaagccgc 2116921 gcatcaaatt cttcaagcgc gcgtccgtag ccttcagggt cacggcggtg tccgaataac 2116981 gcgtcaaaat caacaaggtt cgcaaagctc agacccgtaa aatcttctcc cagcgtatcg 2117041 atcaccttgt ccattccgtc catattagaa accgttctgc gtgaagaagt aatgccttct 2117101 ccgtcgtaaa tatcagagat tttaccgatt gaaatcacat ctaagccgca gtctttcaat 2117161 tcattcatga cagtgcggtc aaacggcttc agcgcataat catggcggtt tggcgtccgt 2117221 ttgaattgac ccggctctcc gacgaacggc cgtgcaataa tgcggccaac catatatttc 2117281 ggatcaagcg tcagctctct cgccgtttcg caaatgcgat acagctcctc aagcggcaca 2117341 acctcttcgt gagcggcaat ttgcagaaca gagtcagcag acgtgtaaac aattaaagcc 2117401 cctgtctcca tgtgctcctg gccaagctca tccaaaatcg ctgtgccgga agccggcttg 2117461 tttccaataa ttttgcggcc agatctcttt tccagctctt gaagcaattc atcaggaaag 2117521 ccttccggga acactttaaa cggtttatca atgtataaac ccataatctc ccaatggccg 2117581 gtcatcgtat ctttgccgtt tgacgcttct tgcatttttc cataataggc aagcggatgt 2117641 tctgtttttt ctacaccttt gatatcttcg ataagaccaa ggccgagctt tgccatattc 2117701 ggcatatgta atccgttcat atgctcggca atatgaccga gcgtatgagc gccttcgtca 2117761 ttaaagtcag cggcatccgg cgcttcgccg attccgactg agtccatcac aattaaaaac 2117821 acacgattat atttgtatgc aggcatcttg aaagcctcct ttttttctat acgtctattg 2117881 tatcgctaag aggtctgaca actcaagtat aaaccgtttt cattcccgtt gacaatgtat 2117941 ttggaaataa tgagaaactt caatattttc tgtcgctcta aacaaaaaag ccgcagccac 2118001 ctgcggctat gctcgcggat gaaactgctt gtacacatcc ttcagccttg ttttcgtcac 2118061 atgcgtataa atttgcgtcg tggatatatc cgcatgaccg agcatttcct gcaccgctct 2118121 taaatctgcc ccgttctcaa gcagatgcgt cgcaaaggaa tgcctgagtg tatgcggagt 2118181 cagctctttc ttaatgccgg cttccaatgc gatttttttc aggttcttcc aaaatccctg 2118241 gcggctgatc tgtttgccgt gatgatttaa aaagagggcg tcagatacat tattttttaa 2118301 cagttttccc ctggcttttg tcatatattc ctcaatggcg gaagcagcgg cttcaccgat 2118361 tggcacaatc cgttcttttc ttcctttgcc gaagcatcgg ataaacccca tagataaatg 2118421 aacatcagcc gttttcaatt caatcatttc actgactcgt atgcctgtcg cataaagcag 2118481 ctccagcatt gctttatccc gatatccgaa agggctcgtc agcttaggcg tgtccaataa 2118541 ccgctcgact tcattgagcg cgagcacctt cggaagcgcc cgttccgtct tttgtgtttc 2118601 gatatgaacg gaagggtcct tatccgttac tttttccctg agcagaaatt gatgaaaaga 2118661 gcgaatggat gccaaatgcc gcgccgatgt cttgccggat ttccccgagt ccttcaaatg 2118721 ctttaagtat tggataatat gtatgcgggt aacgtgattc caatctgtaa catgaagggt 2118781 ttctgttaag tagagagaat agcttttcaa gtcacgttca taggatacga tcgtattttg 2118841 agagagccct ctctctacca taacgtagtg gatgaaatcc tttatttgat ctttcactct 2118901 tgatctactc cccgttttgg taaaaaaaga tcaaccggtc gaaccatccg cctttttcat 2118961 cctgatccat ttcaacaact tttacagcgg agccttccgg tttatcatac cgatgatagt 2119021 tttcatactc ttgattcacc catatcatag cataatagaa caaagcggta aaaccggtaa 2119081 acaggatgaa aactttcaat gcatcgacag ctgttttcag gaatcttccc atgtcctaat 2119141 cgatcctttc cctatggttc cagttatata aaccatatgc caaatcagaa aggttttata 2119201 catagaaaca gcaaaaaacc ctttccccat gagaaaaggt tcgcgctcgg caccgtctat 2119261 tcagtttctt ttccgttaca gcggtggcaa atgccgtgaa acgtcaatct atgatcttta 2119321 atcttaaatt tccaatcacg ttcaatgatt tcttccacgt cttcaagcaa atcttcttca 2119381 atttcatcaa cggctccgca ctccatgcac accaagtggt gatgaaagtg agctgcgccc 2119441 tctttccgaa ggtcgtaacg ggacacaccg tctccaaagt taattttatc tacgactttt 2119501 aattcagtta ataattcaag cgtacggtat actgtagcga gaccgatctc aggagatttc 2119561 tcttttacga ggaggtatac atcttctgcg cttaaatggt cttcttcgtt ttcaagcagc 2119621 actcttactg tcgcttcacg ctgtggcgta agtttatagc tggatgagtg cagttgtttc 2119681 ttaatacgat caatacggtt ttccatgtct ttccctccta cgccgcattc catgactcat 2119741 tataacaaaa tacgcgcaga gttccaacta taattattat aaactgataa ataaaatggt 2119801 tttcttttaa taatgatttt aaaaaagtct agatgtaagc ttttccatta aaacaggaga 2119861 taagtatgct tcaaagagag atgaaatcag cgctaaaaac agaatgacca gcagcacaaa 2119921 ggcataccgc ccgaaccatt gaatcggcgc gtcatgcagg cttcgtttca cgaacagctg 2119981 tctgattaac tttaaagaaa acgcaattgc acatgtgccc ataatgagat aagccggaat 2120041 cagcagcaca ttttgcggca aaacggagac aaatgatagg aaaaacccgc ttactcccat 2120101 ctgattgact aggaacccga cagtaaagcc gacgacgatc cctttcagaa agatcataat 2120161 gaaaataatc ggcatcccaa tgacggaaat tcccagtatc cacatcaggc ctaaatactt 2120221 tgcattatga aagatacttt gcccaaacat atcagctgaa cttgcctgtt ttccatccga 2120281 aagctgtcca aaaaattgac ttaagtagta gtataaatct tctttctggc tgatggtcat 2120341 actgttgaca ataatcgcgc caaagatgac acccatgaaa aacagcactg acacaaatat 2120401 ataaagagag agatgatctt tgacatgcct gagaaacatg tccttataag agatttttcg 2120461 cataccgttt cctcccgccc gctctagtga tttgatttaa tagattgtat gaaagaaaca 2120521 gaaaaacatg ccctttttca aaaagaaaca atagagatga atgctaggcg gctttttggg 2120581 gcacaaaaaa atccttatca tcaactgctg tatgatcata aggattctta tgcttccgtt 2120641 tattcaaaat ctcttttttg ctttttgtca ttcttccatg tgtgctgaaa gatggtgtgc 2120701 tgcctcttga taataagacg tcacgtccgc cgtttctcaa tcgatgcccc cgcttctttt 2120761 tcgcttggct ttttgccatg tgatcactcc cttttttatt ttcatagtaa tgataacaaa 2120821 attgaacaat gataagaaaa aaacagcacc tgctacgaca ggtgctgttt agctacattt 2120881 atttcactgc tgtaagagct gcatgctcga cagctgctgc taccgcatga tggacttttg 2120941 aatcaagcgg ctgagggaca acatcacctt gtttagtgca agctgcgatg gcctctgctg 2121001 ctgcgacaag catatcatga ttaatctccg tgctttttgc gttaagcgct cctctaaaaa 2121061 tccctggaaa accgagtaca ttattaacag aacgcccgtc agctgcatat gcggcgccag 2121121 cctgcagtgc ggcctccggc tcaatttccg gcttcggatt cgataaagcc agaatcactt 2121181 gaccagaacg tacaaatgcc ggttttatta aacccggaac gcccgttgta gcaatgacaa 2121241 tatcacatgt ttccataagc tcctcaatac tggaaactgc ctgtccgccg tattgttcga 2121301 gacggttcat tgctgactct gatttgtctg ttccgtatac agcattcaca ccataagcca 2121361 tgaacatccg gcagatggcc acgcctgctg cgccaaggcc gatttgcccc actttcgctt 2121421 ccttcaggtc aacccccgca ctcctgcatg ccgaaatggc agctgccagc gtcactacag 2121481 ctgtaccatg ctggtcatcg tgcataacag ggatgttcag ctcctctttt aggcgatcct 2121541 cgatttcaaa acaatgcggc gaaccgatat cctcaagaag gatgccgcta aagcccggag 2121601 aaatatgttt tactgttttg atgatttctt caggatcact cgtatcaagc agtatcggaa 2121661 tgccgctaat acccgccagc tgatcaaata aagcagcctt tccttccatg acaggcatgc 2121721 cagccacaga gccgatattc ccaaggccta aaattgcggt tccatccgtt acaattgcaa 2121781 cagaattgct gatcgttgta taaatagaag ctttttcagg ttctttttcg atcagtcggc 2121841 acacgtccgc aacacctggt gtgtagacac gtcccagctc tgccagtgaa cggatcggca 2121901 ttttgctttt catttggatt tttccgcctt catgtgcgga caggacttca tcagatacgg 2121961 tgtgaagcct gatcccttct ccgagggcct gtacagccgc gatcacttcc tgaagctgtt 2122021 cttcattctc cacttgaacg gtaatattcc gcattgtgta attgggtccg acttttaccg 2122081 tctccacttc accaatatcc ccgcccagaa ggccgatggc cgtagccacc cttccaagat 2122141 ttccgggaac cgaaggcgtt tcgatcatca gtgtccgaat catgtgtttc gctatcattc 2122201 agtgatcctc ccctattagc ctagtttttc ggctttaact gtattgtttt tcgtatacca 2122261 tataaatttt cctgtataac catagataat tgcaagacct attgctacaa aactgagcca 2122321 cataaacggc agataagaga aggtagaaac acctaaaata ccagccatgt aaatcccatt 2122381 atcagaccaa ggaaccatcc ccgaagtcaa tgttcccccg acctctgagt tacgtgataa 2122441 cactcttctg tccagatgta agcgatcata gctgtcttcc ataattttcg gagtcaaaat 2122501 aagagataca tacatcgcac agccgaagat gtttgctaaa aacgctacga tcagtgtaga 2122561 caatgtgaca ttgccggctg aagttaattt cttttcaaac gttgaaacaa tgacttttaa 2122621 cacgccgagt ttctcaagca gaccgccaaa accaaggcca aagatgatga cgacgagaga 2122681 atcaagcata ccgacaattc caccgcggtt taacaagccg ttcaaaaatt caacatccgt 2122741 tttaatagag aagccgttgt acgcagttgc aatcgcatgg gcaatatcca ttccttggaa 2122801 aacaacagcc cagattgcac cgagtaaagc gccaattacg ataactggca tagatggctt 2122861 tttcatcgcc aataagacta tgacgagaac tgccgggatc agcatccaaa tatgaatgtc 2122921 aaacgtgttt tgcaaagatg attttaagaa ttcaacttta tcaagatcaa tatttttccc 2122981 gccgtacata aatccaacaa ctgtaaagag tatagctgta atgacataag caggtattga 2123041 taaataaagc attgctctca cgtgagccaa tacatcgact tttgatagtg aagaagctag 2123101 aactgtactg tcagacagcg gagacagctt gtccccaaaa taagcacctg aaagaatagc 2123161 tcccgctact agaggaagcg gaatgcctaa cccctctcca attgcgatca tggcaatgcc 2123221 ggcagttccg actgttcccc atgacgttcc tgttgccaca gacataatgg aacaaataat 2123281 taacgttgcc agtaaaaaga tacttgggtg aataaattcc agtccgtaat aaatcaaagt 2123341 cggcacaacg cctccggcaa tccatgttcc gatgagcgcc ccaactgaaa cgagaatcag 2123401 tacggcttca aggccatttg atatcccatg tacaatcgca ttttgtaaat ctttataaga 2123461 ataaccgagt ctaataccta aaagcattgc aataaaccat gaaacaaaaa gcgccagctg 2123521 tatcggcaag tcgagaaaga ctgtaaacga tagaacaagt gctaaaaata ctcctagtac 2123581 aataataatt tcaaatagtg ttggcaatct tacatccttc aaaagaagtc ccccttcatg 2123641 taaaagctaa aacgctttca atatatagtg caacacgtat actatacttc ctcatcccta 2123701 tgttgtaaac agcttattca tccgactatt cggagatgaa taagctgtat tttatacaaa 2123761 ttttattttt ctaatagttc tttccctgcg atacctggtt tggtcatctc atatgggttt 2123821 aaaataatat ccaattcttc ttcagtcagc acatcatgct gcagacaaag atcccggaca 2123881 gattgccctg tcataattgc ttccctggca attctagctg ccgcttcata cccaagatgc 2123941 ggattgacag ctgtgatcac gcctgcgctt ttttctacgt attgcttcat acgcttttcg 2124001 ttggcttcaa tgccttttaa gcagttgtca gtgaacgaac ggaagccgtt gttcatgatg 2124061 ctgatggatt gaagcaaatt aaagacaagc acgggctcca tgacgttcaa ctcaagctgg 2124121 ccggcttctg aagcaaggca gattgtattg tcatttccga taacctggaa cgcaatttgg 2124181 ttgatcagct ccgccataac cggattgact ttccccggca taatagatga acccggctga 2124241 cgtgcaggca gagaaatttc cgcaagtccg gcgcgcggtc ccgacgccat taagcgcagg 2124301 tcgtttgcga tcttcgacat gttcatcatg cagactttta atgaagctga tacctctgta 2124361 taggcatctg tattttgtgt cgcatcaaca agatgatcag cgccgacaag aggaagcccg 2124421 ctaatatcag caaggtgctt tactacctgt ttgatatatt caggatcagc gttcagccct 2124481 gtaccaacag cagttgcgcc catgttgact tcatacaggt gctggcgcga ttgcttgatt 2124541 cgtttgatat cacgctcgag aacacggctg taagcttcga attcctggcc aagacggatc 2124601 ggaaccgcat cttgaaggtg tgtccggccc attttaataa cagagtcaaa ctcctgtgct 2124661 ttttgcttaa acacactatg catatcttcc attgttttca gcagtttttc taagagcttc 2124721 aatgtggaaa tatggatagc agtcgggaac acatcgttcg tagactgtga catgttcaca 2124781 tgtgtgtttg gacttaaatg gatataatct ccctttttat gtcccatgat ttcaagcgcc 2124841 cggtttccga taacctcatt cgcgttcatg ttcatagaag ttccggcacc gccctgaatc 2124901 ggatcgacga taaactgatc gtgccacttg ccttccagaa tctcgtcagc ggcttgtacg 2124961 atagcttggc caattccttc atacagccgt ttcacgtcca tgttggcaag agccgcagct 2125021 tttttcacaa tcgccagtgc gttaatcatt tcctcatgga ttttgtatcc tgtgatcgga 2125081 aaattttcag aagcacggag cgtctgaatt ccgtaataaa catctgcttc aatttgtttt 2125141 tccccaagga agtctttttc cacgcgatat tctttttggc cgtttaacat aatctttaac 2125201 cttctttctc tttgctggtt atcgttttta cattttacag gacaacgtca tcagctatcg 2125261 gcgtttccat aattctcttg acgacaggaa gatccgaaga ctgacctagc gcccacatca 2125321 attttggcac aattgcttct gtgttcatat ttcttgatcg gataattaag tcttggttga 2125381 ctctgcggcc aacctcgtaa atgctcatgt cttcgccttc ttcaagacat tgagtcgtaa 2125441 tgacgacgac aatgccgctt tcgatcagtt cattcacttt tgacaaaatg tctctgcctt 2125501 caaacggcac tcctccgctg ccataactct caatgacaat tcctttgtac atgcttttca 2125561 gggcatcaaa catttcgggc tttaagcctg gatgcagctt cagcagacat acatctgtgc 2125621 atagtgaagt gtcaactgtg aaggtgtcgt tctcaggttc cgttacttgt ttgttgtatt 2125681 cgatcccgtc ttcattgata aaagcgatat atgggtaatt gatgctttca aatgcgtcgt 2125741 agcttttcgt tcttaatttg atcgcacgcg ttccctgaat gactctgccg tcaaacacaa 2125801 cataaacgcc gcccacgcct tcacaggcaa atcgaatggc atctgtaata ttttttttgg 2125861 catcggtttt ttggaacgtg atcggaatct gcgagccggt gatgacaatc ggctttttgg 2125921 catgctgcag catatacgat agtgcggcag atgtataggc cattgtatct gtaccgtgag 2125981 taataacaaa cccgtcatag gcatcataat tttccttaac ggcttctgct atttccaccc 2126041 agtattcagg ctgcatattg gtgctgtcta tattcataag cgactgagtt tccattgtgt 2126101 aatcgttatc aagttttgat acgtaactta ataattcatc agccttgact ccgggagcca 2126161 gcccattttc cccttcaact gaagcaatcg ttcccccagt tgtcaacatc aataattttt 2126221 tcataccatg cacctcttca ctgtatctaa agatgggttg cgagaaggta ttcgcttttc 2126281 gcatactttt aatgcaatta tagacacgga aaataaaata cgcaagacat tattattcaa 2126341 ttcgcgtaca cttcctaata cctatatgat ataatcagct caaggtgaaa aaggagcgga 2126401 agttcatgaa tctagatcgt ttaactgaat tgagaaaaaa gaaaaattgg tcgcttcaat 2126461 atacagctga ccttctcggt atcgcaaaaa gcacatatgc cggctacgag tcaggctacc 2126521 gacggccttc acttgaagcg cttgccatgc tggctgacct ctttgacaca acctgcgatg 2126581 aacttttagg ccgcgagaaa caaaagcaga ctgctcctca ggccatagaa ttggccacgt 2126641 ggagcagcct cgactttacc atttctgttg atggccagcc gctgagtgaa gatgaaatca 2126701 tccagctgat tacctttata cgcacaaaaa gaaaagtaca ggaggaactg agttaatctt 2126761 tagctcacgg tttaatttta ccgtaggttc ctcctcctcc ggctttcaat tccagttttc 2126821 cggatctcgc ttttacgata agcgccgcgg ttttcggcgg gacaacgcga gccaaatctt 2126881 cttctgcagc ctcatgaaga acagccattt ctgttccgaa ggcttttttt agtttgtcca 2126941 gcgttttcgg gcctacaccc ggaacaaatt gcagcgggat ctgatgtaca tatcgcggac 2127001 gcgggacgcg aacttcaagc tgatcactca attcacgcaa tctatcgctg actcccttgg 2127061 taaatctggc ttttccgcaa ttcgcgcacg ctgtttcccc gcttacagca ggctctccgc 2127121 acgcttcgca agccgtctga taatatttcc ccaataacgg gtccaagcca taatttgcga 2127181 taattttcct gtcatcttgt ccctttaatg caagagcaaa ttcagtaaaa tcagctgact 2127241 gcacatataa ttcattatat tctctgccga ttttccccaa cgaatgcgca tcagaatttg 2127301 ttaaaaaagg atacggattc aattgcgata cgtgtgatgc catgtctgta tcacagctta 2127361 atccaagctc caccgcgtct atcatagatg gatcaaaaac ctcagttaag cttgatttaa 2127421 ccccttttcc atataagctt ttatgcggcg taaagatatg ggcggggata aacaggccgc 2127481 ccatatcctg cacttttttt tgcaggttta agcccgtttc ataaatccgc tgcgagctta 2127541 aatgaatatt tttcagccgg gctgacagcc agtttgaaaa ctgtttcata tcagccagcg 2127601 tcggcataaa tacgagcaca tggatcggtc cgctgcaggc ttcatcataa atctccagct 2127661 cgctccccaa taaaagagtc gtgctgcgat aacggattcc tcccccgtca agctcgcgat 2127721 attttccaga tgaaatgcct tcctcaagct ctagaatgac ttccggagaa tgacagtcga 2127781 taatgccgag gagttcaatt cctttatgtt cactggcttc aaccaaaatt ctgtccagcg 2127841 ttaatgtttt ggcgcctgtt attttgacag cccttcctgt aaaggtccgg ccgatatgaa 2127901 tgtgcaaatc cgcgtaaatc tttttcattt ttgtgcttgg agcgcttctt tcagctgaag 2127961 atactgaatc gcgtaggctg ttttagcatc atatacttca cgcgattcaa ccagctttag 2128021 cgcatcttca agcgtcacct ccatcacttc aacaaactcg tcctcatcaa gctcccgttt 2128081 ttcttcaagc acagaaagct cctcagcaag aaaaacgtga acgatttcat ctgcaaatcc 2128141 gggtgatgta taaaacgcag ttatttttgt cagttttttt gctgtataac cggtttcctc 2128201 ttcaagttcc cgaagtgccg tatactccgg ctcctcacct ttttcaagct taccggccgg 2128261 aatttcaacg atcgtccgct caagcggctt acggaattgt ttgaccatga tgattttccc 2128321 ttcatctgtg acggctagta ccgctacagc tccagggtgt ttcacaattt cacgtttact 2128381 ggctttgccg tttggcagct ctacatcctc gacataaaga tcaatgactt tacccgaaaa 2128441 aatctgttct ttggcaattg ttttttcttc taatgatttc atttcttcat ctcccgttct 2128501 gtctctatat gatgccccat acattttatc atactagagc aaaagggggc ttcttcgtga 2128561 aagtgcaccg catgccaaaa ggtgttgtct tagtcggaaa agcatgggaa attcgagcga 2128621 agttaaaaga gtatggacgc acatttcaat atgtgaaaga ttggatctca aagccataaa 2128681 agttgaaact ttagctcctt tatattacgg tcaatacaaa gcctaaaaaa ggagtgtgca 2128741 catgagaaag cgcaaattgg gtacatctga tttagacatt agcgaagtcg gactcggctg 2128801 tatgtctctt ggaactgaaa aaaacaaagc attgtccatt ctggatgaag cgatcgagct 2128861 tggcatcaac tatttggaca cagcggattt gtatgaccgg ggacgcaatg aagaaattgt 2128921 cggtgatgcg atccaaaaca gacgccatga tattattctg gcaacaaaag cgggaaaccg 2128981 ttgggatgac ggaagcgagg gctggtattg ggacccttca aaagcttaca taaaagaggc 2129041 ggtaaaaaag agccttacac gtctgaaaac agattatatc gacctttatc agctccacgg 2129101 cggcacgata gaggacaaca ttgatgaaac gattgaagcg tttgaggaat taaaacaaga 2129161 aggtgtcatc cgctactacg gcatttcttc catccgcccg aatgtgatta aagaatatgt 2129221 aaaaaaatca aacatcgtca gcattatgat gcaattcagc ctgtttgaca gacgccctga 2129281 ggaatggctc ccgcttttag aggaacatca aatcagcgta gtcgccagag gtcctgttgc 2129341 caaagggctc ttaactgaaa aaccgcttga tcaagcttca gaaagtatga aacaaaacgg 2129401 gtacttgtcc tattcattcg aggaactgac aaatgcccgt aaggcaatgg aggaagtggc 2129461 tcccgatctt tccatgacag aaaagtcgct gcagtatctg ctagcacagc cggctgtcgc 2129521 ttcagtgatt acaggcgcca gtaagattga gcagttacgg gaaaatattc aggcagcaaa 2129581 tgcacggcgt ttaaccgaag aggaaatcaa agcgctccaa tctcatacga aacaagacat 2129641 ttacaaagct catcgctcat agcagaaaaa ccagcacctg tacgggtgct ggtttattta 2129701 tattgatgcc aatccatttg gctttcattt aggagttctt caaagctctt atttttttcg 2129761 atctcttttt tctttctaat ctgttctgct ttttctcttt tctgcctctt ttcatcctct 2129821 tccttcaatt ggctcttcat ctccataagc tttgctttga tatcggattg aaggccgtct 2129881 tttagctggt gtttgtcaat ggatttttgt tttttcatgc agacttcccc catgttttgt 2129941 tttgaagcca gtttatcacg gagcatataa actgaacaag cagactctct tctgatcact 2130001 ttctcagcgt agcagtgttt aggtataatg atcttaaaca cgaattgcct atatatttcg 2130061 ttgaaaggtg ctgtgacttt tgaagaaaat ccttttggcc attggcgcgc tcgtaacagc 2130121 tgtcatcgca atcggaattg ttttttcaca tatgattcta ttcatcaaga aaaaaacgga 2130181 tgaagacatt atcaaaagag agacagacaa cggacatgat gtgtttgaat catttgaaca 2130241 aatggagaaa accgcttttg tgataccctc cgcttacggg tacgacataa aaggatacca 2130301 tgtcgcaccg catgacacac caaataccat catcatctgc cacggggtga cgatgaatgt 2130361 actgaattct cttaagtata tgcatttatt tctagatctc ggctggaatg tgctcattta 2130421 tgaccatcgc cggcatggcc aaagcggcgg aaagacgacc agctacgggt tttacgaaaa 2130481 ggatgatctc aataaggttg tcagcttgct caaaaacaaa acaaatcatc gcggattgat 2130541 cggaattcat ggtgagtcga tgggggccgt gaccgccctg ctttatgctg gtgcacactg 2130601 cagcgatggc gctgattttt atattgccga ttgtccgttc gcatgttttg atgaacagct 2130661 tgcctatcgg ctgagagcgg aatacaggct cccgtcttgg cccctgcttc ctatcgccga 2130721 cttctttttg aagctgaggg gaggctatcg cgcacgtgaa gtatctccgc ttgctgtcat 2130781 tgataaaatt gaaaagccgg tcctctttat tcacagtaag gatgatgact acattcctgt 2130841 ttcttcaacc gagcggcttt atgaaaagaa acgcggtccg aaagcgctgt acattgccga 2130901 gaacggtgaa cacgccatgt catataccaa aaatcggcat acgtaccgaa aaacagtgca 2130961 ggagttttta gacaacatga atgattcaac agaataaaaa agcgaaaggc ctcttcggct 2131021 ctttcgcttt tttatgttac agaacgtcgg taatgccatc catattttct ctgatccatt 2131081 caatcgcaag atctatcgtt gtaaactcct gcgtctcgaa ggtcatttca tcctgcaata 2131141 gccagacatc tttcttgatg gactctgctc ctccgattga ccagtgaagc aaggtataag 2131201 gatggttttg attcaggaag gatacccacg ttttattttg tgctgtgttc ttcattgcct 2131261 tcagcttttg ttccacgttt cgcgtctcct actttactaa tatgctcatt ctggggctga 2131321 gcatttcagc cgggcttttc agcgccaatg ttttggcttt ttcattgtaa tcgatcgtca 2131381 tttgatcgtc aaaaaacact ttttgcgacg attggatata cagcggaatg ccgttcgttt 2131441 ccagctgctc gcactgtccc gttaattctt ctgccagcca gattgtcggg acaccgctta 2131501 ccgcgcagcc gcatccttct gcatcgtaac gaagctgggc tttttttccc gggttggcgt 2131561 caaacgcctg ctgcagtgcc tgttttgctg catctgtcac atgtatgttc ataaggtgaa 2131621 acccccgttt tcatcatttt cgctattgta gcatacaata ctgccattcg cattgtttct 2131681 gccttttttc caccgcttcg cattttcttc tgcagtcttg atccactcat ctttcccttg 2131741 tatatactga ttgatgctgt cagggtgctg ggccgccagc tgttttttga gaacggcgta 2131801 ttctttcgct atgtttggat gagctctgag ataatctctg aataacagat gcctttcaat 2131861 agcagggttt ccctgttcgt acatatggac atgatgagtg cgtttatttc cgcccttttg 2131921 gaaataacgc ctgcccgcta taccgttctc accttttggt gtatagccgt tggccttcat 2131981 ttgttcatca aattggctca cggcttcaat gcttctgact tcaattaaca tatcaatgat 2132041 tggcttcgct gccatgttag gtattgatgt gcttccgatg tgatgaatag cgataatctc 2132101 cggcccgaac acaagtttca gccgttcttt ttcttcatcg aaacattctg cccatttttc 2132161 gttgtagaga atgatctcaa cttttctttt cggatacaaa tgaaagaccg acagcaatag 2132221 accctgcgct gctttgacgg tttctgcctt ttggaatccg gcctgtgtat agagtgacac 2132281 agccggggta ttgttctcgg ctgtgactac ttcgattttc tcagcgtctt cattatgatc 2132341 aatgacaaat tgcagaagcg ctcgtccaat tccttttctg aaaccgtcag gatgcacaac 2132401 aagcctgcaa atggtgagat aatgcatgtt tttctcatat gaaatgacac cgatcagctt 2132461 gccgtttttc cgatatcccg caaaccgttc atgggatgct tgaatatcct ttaccttctc 2132521 ttgtaaagcg ggaataccgt caaaaccgat aatctctgtt tcctttatgt aggcggggat 2132581 ctgtacggct aaaatctcac gcgctatagt ggcttcctta tgctggagaa attcaatcat 2132641 tcgtgttctc ctgaaacagc cgctgtctgt cgacttttgc gacgcggact gcatacgact 2132701 cgtaccaaac gcttcttcct ttttcttttg ctgcttgatg ttcagtgtga tgcctccaat 2132761 ggttaattgc gtccatactg tcccaatagg aaactgtgat gccccttcca tccgcttcac 2132821 gtacgctttc cacgcctaaa aatccaggct gatccgccgc aagtgatacc atccgctccg 2132881 ctgtttctcc atatcctgtg tcattttcgc ttttgacaga agaaaaaatg actgcatagt 2132941 aaggaggctc aggtgttttt gataaaaaat ccatcatatt tccccctcat atgtttttga 2133001 caaatagtac cctgtcttgg cccgggccat catagtttgc aaacactgag atgccattta 2133061 ccgttttggt gcccttttca atatcaaacc ccaattttgt gtgatatgcg attgatacct 2133121 tattcacagg tgaagtgaca cacttcaccc gggtgcagcc cctttgtttt actgtttcga 2133181 taaatacatc atacaattgt ttcccaattt gcatttttct gaaatccgga tgcacaccgg 2133241 aaaaatgaat gtacgccgtt tcaggatcgg attgcgattg aaatccgatt aaaaatcccg 2133301 tcatgctgtt atgttcggat gtaataaagc ttgtgtcctg aaaatgctca aaaaatagtc 2133361 tcggcaattt ttctttcagc tgtctgccgc cccaccattc attcagtaca gacgttacca 2133421 tttcataatc tgaagacgtg attgttcgaa tatccattac gatttgatct ccctccgtct 2133481 ggcaaaacga atgtcagctc tttttctcac aatataaaaa ttatattttg cctggctgga 2133541 attgtaaatg ccttctttcc tgtatcatac gtttccagac tgccgaggga acaatgtttg 2133601 atcattttac gcctatttct cccccaaaca ggaggagaga ctttacagca caatatcaag 2133661 cacttgatca agtttcagct tataaagctg atcctcgtct ccttttatcc atactgcttt 2133721 ttcaaactct tcataccggc agattttccc ggtgcagcag acaatctcac cgtcctgaaa 2133781 gcagctgaca gtgatatcct gagcaaactc catcgcggcg caaagcgttt gattcatctc 2133841 ttccagctta tcggggtcaa ggatcggctt ttgcagcttc tgtttaagtc gctttctctc 2133901 cagcaggctt tgcttatgtt ccggcagaaa catcctgctc ccttcccaca gcaggttgcc 2133961 cctttttaaa tggtcgttca tttataatgc ccccctattt tagccgcacg ttcaaatgcc 2134021 tggcctgccg ctgtcagtga cgccgccctg atgattgctg tatcgccgaa tcgattttta 2134081 atgccatcca tcacatagcc taggctcatt ttctttgcat aatcctgaaa taaattgagc 2134141 tgccatatgt catcagatga gagctgagac agattgacac cgaggcggcg gacgggtttc 2134201 ccgtcccaaa atgtaagaaa cagccgtcgt acagcctcat atacatcctg cgtagaatta 2134261 gtcggctctg ccagcttcac ttgccggttg aagcccgtcg gccaatcaaa atcagcaccc 2134321 cggcagctca ctgacactgt ctgccccatg accccggcgt ttcggcttcg cctgcacacc 2134381 tcttcactca gctcaagcaa tacgaccttg atttctttgt caaagtgttc gtagtctctc 2134441 gggagagtca ttccatgacc tatcgccttt tgcccgtcca gagacgaagt tgacacaggg 2134501 gaatagtcga ttccgtttgc cgtcatccac agcacgtggc cgttaatgcc ccatttcttt 2134561 tttaaaagat cgagcggaaa agccgcgagc ccgccgatcg tgctgatgcc cattcgattt 2134621 aaatgatgct tcatgcggct cccgacgcca aacatgctgc ccaccgggag cggccacatt 2134681 tcggttttca tattttcttt cgttaaggta aaaataccgt tcttattctt tttggcaaaa 2134741 ttgtcacacg caattttggc cagcgctttg ttagggccga ttccgacccg tgcataaacg 2134801 ccgatctccc gcatgattct gccctgaatg cttttcgcga tctccatcgg cgtcccaaac 2134861 agcttctggc tgcctgtaat gtccatgaac tgttcatcga tggaatacgg ctccacaagg 2134921 tctgtatact cctcgagaat ggccgtaatt tgcagtgata catcaatata ccgctgcata 2134981 cgcggccgga gcacaacagc ctcaggacac ttttcctgcg cctcccacag ccgtgaagca 2135041 ttcaccacac ccttttgttt cgccagcggg caggcagcca atacgactcc gccccttttt 2135101 tcagggtcac ccgaaacaat gacgggccta tttttcaaat gtggattttc cgctttctct 2135161 acagatgcat aaaacgattg catgtcaacg agaaaaatca ctttttcttt catcatacac 2135221 acctctaaaa agaacttatg ttcgcttttc attatatgcg aaagtatgtt cgttttatac 2135281 tggtaaatga ttcttgtctg acagaaaata tgatccaagg gtttgagaga agaaaaacat 2135341 ttagtagaat aaaagcgaag cataaggata ggagagtcat gatggagaaa tttgtcgaaa 2135401 aaatgctggg acaggcattg cggcaatacg gcagaaacgt tgctatagat ccgttaagcc 2135461 cgtatgaaaa acaaagcctg aaagcggctc tacaagagag acggaatgaa gaaccagatg 2135521 aggatttgca tgcgcatata gaagatatca tttatgacta tgtcacaaac caaggcctgt 2135581 tctcttaaac gcatgactgt cagttctttc agccgctgat gcggcttccc tttgaaaaca 2135641 ccgcctgaaa caaataaaca gtctcaggct tacagaaaaa aagcaggatt ttctcacgct 2135701 ccatagattc atatggcctg gcgtaaaatt cccctcaatg ctcgcgcaaa acggaataag 2135761 ctgtccatga tcacgcgtat acactttttc gaagagatgt gctctcttgt tctgtcatgc 2135821 ggtccatgcc ggttttcagc gtacatcttg atctcatagc cggtttcact gccgatatga 2135881 tccacgttct ggcggcttaa actaacacac cctcactgac caatcgcttt gcttttcatc 2135941 ggacatcccg tcattttcct tctttcaaga tgtaaactcc gtcagccaca cgcatcctca 2136001 acgcatagta tattgccatc catacaatca ggcatactac atgtcaataa cgaaatattt 2136061 tgaacgatct attggagaag gaaatttttt catatatgat agagaaagat catacataca 2136121 ggagagaata taattcatga agaaatggaa agatatccac ccgatcagct ggacaattat 2136181 aatcggaacc attttcggca gaatggcaac atcgatgagc attccttttt tagcgattta 2136241 tttgacagcc gtccaaggcg catcagcttc ctatgcaggg ctggtcatcg ccgcgagctc 2136301 atcagtcggc atcctcgcaa gcttttacgg cggatatatc tcagataaat tcggcagaaa 2136361 aaacatgatg cttgtatcga ttttcggatg gatgctggta tttgcaggct ttgcggcagc 2136421 atctaatctc tgggtgtttt ttgtagtaaa cgcattaaac ggtctttgca aatcactgtt 2136481 tgagcccgct tcaaaggcct tgttgtctga tatgacagaa gaaaaaacga gactgctagt 2136541 ttttaattta cgctatgcgg ctattaatat cggcgttgtc ttcggacctg tgcttggcct 2136601 atatttcggc tcatcgcaat cgactacgcc ctttttggtg cctgcagtca tttacggact 2136661 atacggaatt gtgcttgccc tccaatttaa aaaacatcca tccttatcag caccagccca 2136721 gtcccgaaat atgagcgtgc gggaagcgtt tatggtcacg caaaaggatt atctttttac 2136781 cattgctttg gtcggcatta cgctatgcac cttcggctac tcacaattca gttccacatt 2136841 ccctcagtat atggcgcaga accccttgat cggcaatgga acgaagctgt atgggctgat 2136901 gctgacatta aacgcaatcg ttgtgttggc gacgcaattt cccattgtcc attttgcaaa 2136961 acggttttcg ccgctttgtt ctctgatgct cggtaatgtg atggttagca tcagcatggc 2137021 cattttcacc gtatcacacg gtgttccatc aattgtgatg attgtcatca catttacaat 2137081 cggcgaagtg cttttattct ctatgatgga tttgtatgta gaccagattg caaaaccagg 2137141 attaaaaggc acttatttcg gggcaatcgg tttttcacag ctcggaaacg tcatcggccc 2137201 ttgggtcggg gggatatgta tagacctgtt tggcgctggc cggccgattt atattttttc 2137261 tgtcctgagc ggcattaccc tgctcggcct gccattttta gcgttcgcct atcggcaaat 2137321 gaaaatggag accacaaaac accgttcccg tctggaaaag ccgctttaaa taaaaaacgg 2137381 aagagaatga atctctcccg caaacatgag gtgaagaaca tgaatatagg tgatgtgatg 2137441 tttcagctgt ttgtatttat tatatttgcc gctgtcgtct ttgcggctgt tacaggcttc 2137501 aagtatgcga aaaaccgaaa agcgcagctg gatcgcattg agaaaaagct gaacagcctg 2137561 tccgaagatc acgattaaca gcttggggca acgagctcta ccttaatccg gtctggatcc 2137621 tcacaaaaga ctgcataatg cccgtctcct ccggcaaaag gatgcctgtc tcggtacaac 2137681 acacgatagc cttttgccgt caatttttca gtcatctgat cgacttgaag cttggattca 2137741 gcatgaaatg cgagatggtt cagaccgact cggcatctat ggtattccgg ctctagaaat 2137801 ggctctttcg cctgcacaat cactaggtaa aaacgatctt tcttccagct gatgcctgag 2137861 ctccattttt gatactcttt ataaccaagt tcttttaaga accagcccca aaaccgccta 2137921 gacgcctcca aatcagagac atacagttca atatgatgca catttcatac cctccttacc 2137981 aacacttcct cgaccttatg cccgtctccc ttacgcaaaa tgagatctga cctgaattta 2138041 gttggcaaaa tattttcata taaattcggc cggttgacac tctcccaaat cgaggctgcc 2138101 atctcgtcag cctcctgatc ggacaagtct ttaaatttat gaaaatatga atcaggattt 2138161 tgaaaagctg tttcccgaag caggcgaaaa cgctctaaat accaagtgaa aatccggctt 2138221 tcctccgcat ccacataaat cgaaaaatca aagaaatcgg aaacaaaaat acgcgggttt 2138281 tcccggtcat cctccaaggt gggcgactga agaacattaa tgccttcaat aatcacaata 2138341 tccgcctgtt ctacaacctc gaacacacct tcctcgcggt cataggttag atgggaatac 2138401 accggggcct ttacgctgtc ctttcctgat tttaagtcat tcaaaaattc gagcagcgcc 2138461 tttacatcat agctttcagg aaatcctttt cttgacatca tatttttctt tttcagctcg 2138521 gcagtaggaa ataaaaaacc atctgtcgtg ataaggctca cttttggacg gtcaggcaaa 2138581 cgcgaaagca gcttctgcaa gatccgcgcc gtcgtgcttt ttccgactgc gacactgccg 2138641 gcaatgccga taataaacgg aattttggct gaatgtgggt gcttcaaaaa aacattgaca 2138701 tgcttattgc gttcagccgc agacttgaca tgtaaatgaa gcaagcgaac aagcggaata 2138761 tagatcgtct ccacttcttc aacagataga taatcattca atccttccac agcttttgcc 2138821 tcttcttcag atacagcaat cgacaaatgc cccccaaaac cagaccaaga ctcccgattg 2138881 tgctgtgtat ataaagtatg taggttaagt tctttatttt tcactgttta cacctgactc 2138941 tctgtaggtt aaaaccctta caaagattgt aacggaaaac cttttcactg tctgcttatt 2139001 tttcatttcg tttttttagc aaatcagcac cgattcggtt atacgcagcc atttcatctt 2139061 ttggaaccat gcttcctccc gttccccaga cgacatgtac ggcatgttcc atcttatatt 2139121 tctgagcata gcgccttccc tcttctgtcg aaaaaagctg aaccggcccg aacatgccag 2139181 caagagcaga gggctctaaa tatttatctt cagatacagc cagcatatga agcaaagtat 2139241 aaagcgtatt gtcctctacc gtataacagc cgctcagaag cggttcaatc agcttgccga 2139301 caaatcctga cggcctccct acggcaagtc cgtcagcagc cgtctgatta tccaggccga 2139361 tatcctggac ggagatcttc tcgtgaagtc ctgaataaag ccctaacagc atacaaggtg 2139421 aatgagttgg ttctgcgaaa aacacatgaa catcatctcc gtataaaagc ttcagcccaa 2139481 atgctacacc gcccggtcct ccgccgactc cgcacggcag atacacaaac aagggcgtct 2139541 caagacttgg ctttatattc atacagtcaa gctgtgtttt taatcggctt gcagcaacag 2139601 catatcctaa gaacagctga cgagaatgtt catcatcaat aaaataacag aatggatctt 2139661 gttccgcctg ccgtctccct tcgttcaccg cttcactgta atctgtttcg tactccataa 2139721 cagtgactcc cttttggcgg aggagatcct ttttccactg cttagcatcg gcggacatat 2139781 gcactgtcac gcgaaacccg agtgccgcgc cgatgatgcc gatgcttaaa cctagatttc 2139841 ctgtcgaacc gacagcaatc gaatagcggg agaaaaaccc ggtaaaccgc tcttcctgta 2139901 agatgcggta atcatcggtt tcctgaagca ttccttcttg aagcgcgaga ttttcagcat 2139961 actttaacac ttcataaatc ccgcccctcg ctttaatcga tcctgaaatc ggaagctcat 2140021 ggtcgcactt taaaagccat cttccgggaa atggctgctg atatgccgct tccagctttc 2140081 ccttcatatg ctgcacctca aaaagcggag actcgatgat tcctttagcg cctttcgtct 2140141 caggaaacac ctcggcaatg taaggtgcaa accgctgcat tcttttttcc gcttccgcta 2140201 tctcggttgc ccactcatct gcacggggta atggcccctc tttcttgcct gaatttgccc 2140261 agaatacagg ctctgcatca atcagtttct gaataaacgg atctttaagc agagcatgaa 2140321 ggacttctga atgaactgac attcaacaat ctctcccttc cactatcaaa aactgccccg 2140381 tgagaaacaa gccactccac cacaggcagt tctatcatta ttttttcatg agcgcgcgtc 2140441 ctgccagctt ttctacaaga gctggaaaca gctgatacag cttagtgccg gcattcatta 2140501 aacgcggaag attgatctcc cgctttttcg taaaaattgc agctgtaatt tgagctgcca 2140561 cgtcatcagg atcaagcatc cagcggccga catttttggc gtagtccccg cctttatcag 2140621 caatggaaaa aaagtccgtc tgaatcgggc ccgggttgac tgttgtcaca taaatgccgg 2140681 ttcccgaaag ctccatccgc aaagcgtttg agtaacctaa cacggcatgt ttggtcgcgg 2140741 aatacaggct agacttcggt gtggcgattt tccccgcttg agaggcgata ttgatgatat 2140801 gtcccttttt ttgctcaagc atttgcggaa gcaccgcttt tgtacaggcg atcaggccga 2140861 agacattcac atcaaacatc gctttcatgt catccaatgt agagtctaaa accgtttcaa 2140921 atataccgaa gcctgcattg ttaatcagta catcaatcga gccgatctga tcgcggaccc 2140981 gggcgatatc ctctaggcgg ccgacatcca gaggaaaaat ctcacactgt ccgctccatt 2141041 cctcggttat tttccttttg atttctatca aacgatcctc gcgtctagcc gacagcagga 2141101 catgggctcc ttcagccgcg cataagtatg cgattctttc tccaagccct cctgaagcgc 2141161 cggttatcca aatccttttt cccgctatat gtttcaccca tttcacctct tcattgtttt 2141221 aaagtatacg gtatttcctt cccaatatga cgtgatggct tcttcagcct ccaacacatc 2141281 aaggtgacct gccgtttctg acatcgttaa aaacaattcc ttttcatata cagcaggaaa 2141341 aagctgctga cagacctgaa aagcggtcat cggcttttca tccagcatgc gacgcacatc 2141401 ctccgtcctg ttcctctgct tgtcaaaacg cttctcaatc agcgcttgta cactggtgat 2141461 aggctcgccg tgaccaggaa atacgattgt tggatcaagt tgagacagcc ttcgcaatga 2141521 ccgctgataa tccactaaag gctttgacct gacgtctccc gctttcggcg cttccaaaat 2141581 cggattagac gagctgtttg ccagcagtag atcgccgcca agcatccttc cgcttttttc 2141641 atggaacaga acaatatgcg attcagcatg tccaggcatc tccaacacag accagccctc 2141701 aagcccatct atgcccatac cttctctgat tgattttgtc agagatctcg tacaggaaaa 2141761 tgcgtacgct gatcgaatca gcttttccgc cttccccgta tcaaatggaa cgcctaattc 2141821 aggcagcagc ttttgaaaaa aacgtttttg ccaatccata aaggcttgat tttggctgat 2141881 ataaggttcg ttgaatgtat gcccaatcac ttcgatttca tctgaaaaga catcaagcaa 2141941 gcctgcatga tcagcatgat ggtgagtcag tacaacctgc tcgatatctg acaatttcac 2142001 atttacagcg gcaagctgct cttgtaaggc tctggcagcc tcttttgtat tcggcccggc 2142061 atcgataagt gtcagcgcat caccttttac gaggtaaacg ataacatcgc cgacagcaaa 2142121 cggtgtcggg acgcggatcg caattacatc ttcagttgtc atcctttcgc tccttgtctt 2142181 cattcattat tcatatttta gctttttctc ggtcttgtgt cattattgca gaatgagaac 2142241 aaaccttttt gaaaaagcta ttgacattag cttgtccgcc attgcataat gaacaacaaa 2142301 ctaaaacgag aaccattgga acgctatgac gaggaatagt atacaaggca atggcctaag 2142361 agagcgatac ccccggctga aaggtgttgc ggcccgcttg tttgtagaac ctgccctcaa 2142421 gtcgcggtta ggaaaaccta aacgtttccc gcgttacggg gatttgagct gagcacaatt 2142481 tgtgctaatg agggtggtac cgcgaacctt ttcgtccttt acgtgatgaa aaggtttttt 2142541 gttgttctaa tagaaggagg atatcaatga aaaagatagg atttgtcggc gccgggtcaa 2142601 tggcagaagc aatgatcaac ggcattttgc aaagcggcat cacaaaacca gaacatatct 2142661 atattacaaa tcgctcaaat gacgagcgtc tgattgaatt aaaggaaacg tacagcgtgc 2142721 gtccatgcag agataaaaat gagtttttca ctcacaccga tatcattatc ctcgctttca 2142781 aaccgaaaga cgcggcggaa agcatcgaca gcatccggcc gtatatcaag gaccagcttg 2142841 tcatttcagt acttgcaggc cttaccatcg aaaccattca gcattatttt ggcagaaagc 2142901 tcgcggtcat tcgcgtcatg cctaatacat cagcggcaat cagaaaatca gcaaccggat 2142961 tttccgtaag cacggaagca agcaagaatg atattattgc cgcaaaagct ctattggaaa 2143021 caatcggtga tgcaacactg gttgaggagc ggcatcttga cgctgtcact gcaatcgcag 2143081 gcagcggccc ggcctatgtg tatcgttata ttgaggcgat ggaaaaagca gcacaaaaag 2143141 taggattaga taaagaaacg gcaaaagcac tcattttgca gacaatggca ggggcaacag 2143201 atatgctcct ccaaagcggc aaacagccgg aaaagctgcg taaagaaatc accagtcctg 2143261 ggggcactac agaggcaggt cttcgcgctt tacaggactc ccgctttgaa gaagcaatta 2143321 ttcactgtat tgaagaaaca gctaaacgga gcgcagaaat caaagaacag tttgccggtg 2143381 ccgccttaga gagacattct tagatgtaag gacaaaaaca gaaggcacag tgccttctgt 2143441 tttttatttt tcccgcagca gctggccggc agattctgat tgctttaata gcgcggagat 2143501 cgtaaatgaa agcaaatcgg gaagcacttc aaaggaataa ggcatataca atctttccgt 2143561 ccatttatgc gggtctttac cagccggacc gacatttaaa actgggacat ataaagcctg 2143621 atttttaccg cttggcaatg aataccctct gttaaagagc ggcatattgc ttgtgtatgc 2143681 atcaacctcc tgtttttcca gctgaagata actcaagtcc gaaagtccgg ggaagtactg 2143741 aacctcccgt aatgcaatgc cgtatcgctc agccgcataa tgctttatct gatctgctgt 2143801 atttctgatc aattgatcat cctttgaaga aacagctgga taaagcggcg gactataaaa 2143861 cagaacgatg agcggcgcat cctccttaca aagcgaagca agctcagaaa caattttcgt 2143921 cgaaaaatcc ctgtctccaa gctcccccct gttagcaaag gcataattta gagcccgctc 2143981 tgtttccgag atccccgcac gcttttttgc acgcgagacc agctcatcaa atgtcaaaac 2144041 agtgacgtcc cgctcaatcg gctgaaatgg ctcaaattgt tgaaaatcct gtgttttctt 2144101 ccgaacgttc gacatgattt cctccgccgc ctgttctgct gttttaagca gcatctgatg 2144161 cagctcacta gctgagcgtt tcattgacag cacattaaat aatgtgacgg ctgtatgcgg 2144221 tgtctggact gaatatgcct ctttcaagtc cttttgcatt aagtttaccg gcggcggagt 2144281 gacctcgcca tcaacctttt cgcaataatc agcattcagt tcaagcaaac ggttaatctc 2144341 agataccatt aaatttgcgt ttagacctga aaacggctct ccaacatgtg tctcaatccc 2144401 cttgcagaaa aaacccgcaa gcaccttgcc aatgcttcct gtataaaaat attgctgctg 2144461 atcgccggga aatttttcaa acatcggttc ggcattcagg caagcggtta atgtgatatc 2144521 atgctttttc tccatctcct tcaatgcagg aaccgcttca atcatgcctc ttgaattcac 2144581 ttcctcgtcc ggaaccgtta tcaacagcag attgccctca aaatgcccgt tcattgccct 2144641 ctccagcatc gacagttgaa tacaaagccc cgctttcata tccatcgtcc ctcttccgaa 2144701 cagccagtct ccgctttcgg catctcttct cacacgttcc gggagcagct cttttttctc 2144761 taaaaaggag ctcaaaagct cagcaggctt gcaagccata tgtttaaatt cgccgtaatc 2144821 ttctatgtca acgacatcaa aatgactcag cagaagcact gtctttttga cattcttctt 2144881 tttgactaga gccgtaagaa aagatctgcc atcgtccatc ggatgaagtg ttacatcatc 2144941 agggtgcttt tgaaaatagg gcttgtcctt caaaataaaa taaagatact ctgcaagcgc 2145001 tacctcgccc tttgaaccgg tgatgctttc gtattgcaca agagaagtta aaagtgccag 2145061 caattcgtcc ttcgtctgcc aattcattga ttccgcccct cctatgaata aaaatgcttc 2145121 tatactgaaa aataaactga tttctcgtct attatacaga aatgtttgac aaaagcggtt 2145181 catttgagca gtttatatga cgggaaagaa atgacttgat ataatcaatc tctaaaaacc 2145241 ttacgggagg cgaaagaaat ggccagaaaa ttatttacac ctattacaat taaagatatg 2145301 acgttaaaaa accgcattgt catgtcgcca atgtgcatgt attcttctca tgaaaaggac 2145361 ggaaaattaa caccgttcca catggcacat tacatatcgc gcgcaatcgg ccaggtcgga 2145421 ctgattattg tagaggcgtc agcggttaac cctcaaggac gaatcactga ccaagactta 2145481 ggcatttgga gcgacgagca tattgaaggc tttgcaaaac tgactgagca ggtcaaagaa 2145541 caaggttcaa aaatcggcat tcagcttgcc catgccggac gtaaagctga gcttgaagga 2145601 gatatcttcg ctccatcggc gattgcgttt gacgaacaat cagcaacacc tgtagaaatg 2145661 tcagcagaaa aagtaaaaga aacggtccag gagttcaagc aagcggctgc ccgcgcaaaa 2145721 gaagccggct ttgatgtgat tgaaattcat gcggcgcacg gatatttaat tcatgaattt 2145781 ttgtctccgc tttccaacca tcgaacagat gaatatggcg gctcacctga aaaccgctat 2145841 cgtttcttga gagagatcat tgatgaagtc aaacaagtat gggacggtcc tttatttgtc 2145901 cgtgtatctg cttctgacta cactgataaa ggcttagaca ttgccgatca catcggtttt 2145961 gcaaaatgga tgaaggagca gggtgttgac ttaattgact gcagctcagg cgcccttgtt 2146021 cacgcagaca ttaacgtatt ccctggctat caggtcagct tcgctgagaa aatccgtgaa 2146081 caggcggaca tggctactgg tgccgtcggc atgattacag acggttcaat ggctgaagaa 2146141 attctgcaaa acggacgtgc cgacctcatc tttatcggca gagagctttt gcgggatcca 2146201 ttttttgcaa gaactgctgc gaaacagctc aatacagaga ttccggcccc tgttcaatac 2146261 gaaagaggct ggtaatgccc ataagagata tcctgtagag gatatctctt tttttatttt 2146321 tagagaaacg atcggctaag gttctccgtc tccctagtag aaccaattag aggagatgac 2146381 tccaatgaaa tcagcttgga tggaaaagac atatacaatt gacggatgtg cgtttcatac 2146441 acagcaccgg aaaggatcaa gcggtgtaac gattgtcttt gaggccggct atggtacttc 2146501 ttctgagacg tggaaaccat taatggcgga cattgatgat gaatttggca ttttcacata 2146561 tgatcgggca ggcataggaa aaagcgggca aagcagagct aaacgaacag ctgatcaaca 2146621 agtgaaagaa ttggagagtt tgcttaaagc agctgatgta aaacctcctt atttggctgt 2146681 ttcacactca tacggagctg tcatcaccgg tttatgggcc tgcaaaaaca agcatgatat 2146741 tatcggcatg gtccttcttg acccagcttt aggcgattgc gccagcttta cctttatacc 2146801 cgaagaaatg cacaaatcac atacgagaaa gatgatgctt gagggcacac atgcagagtt 2146861 ttcaaaaagt ctgcaggagc tcaaaaagcg gcaagtccac ttaggaaaca tgcctcttct 2146921 tgtgttgtca tcaggagaac ggactgagaa attcgctgct gaacaggagt ggcaaaactt 2146981 gcacagcagc atattgtctc tatctaacca aagcggctgg attcaagcta aaaacagctc 2147041 ccacaacatc catcatgatg aacctcatat cgttcacttg gctatttatg acgtatggtg 2147101 cgcagcgtgc cagcaggccg ctcctcttta ccaggcagtc aattaacgta aaaaaagacc 2147161 gggccgtaag ggattcccgg tcttttatat tattttgttt cacggtgaag ggtatatttc 2147221 tttaaacgcg gtgaatattt tttcagctcc aaacggtctg gattggtgcg tttatttttt 2147281 gttgtgatgt aatttcggtc tcccgtttca gtgcaaagct aaagtaacat ttactctcat 2147341 aattaacatc tccttataaa acgtaatgat tacgttttat tatacaacgt catcacaaat 2147401 tgtcaaataa gagctccgcc ttcagcctcg cgggacgttt acctctaaga aatcatatgc 2147461 cgccacgcta ttggggaaaa cgtcaaccgc ttctttttga agctccaaag aagcatctcc 2147521 ctgatatctt gcgctgatat gggttaaaat gagctgcttc gctcttgctt ctttcgctgt 2147581 tacagccgct tgttccgttg tactgtgata ataatcataa gcaagtttac ggtcttcctt 2147641 agcaaaggtt gcttcatgaa caagcacatc acaatccctc gcaagctctt ttagtttgtc 2147701 acttactctc gtatcaccgg agaacacaac agatcttccc tttttaggag gctccagaaa 2147761 atcattccca ttgatgattc gtccgtcttc aagcgttacc gtttcgcctt ttttgatttt 2147821 ctgatataca ggtccgggcg ggatgttcat ttcttttaat acgtcagcct tcaaggaacc 2147881 cggtacgtct ttttcctgca cacggtaccc gaaggcttcc actccatgaa taacagatac 2147941 cgctgtgaca ataaactgat cgtcctcaaa cacgattcct tcttcaattt cctggatcgc 2148001 aagcggatat gtcaaatggg ttttcgtgac ggcaaggctt gtttcaataa acgccttgat 2148061 ccctttaggt ccgtacactg tcagctcgtc ctctccgcct tgaaaggaac ggctccccag 2148121 aagccccgga agtccgtata catgatcgcc gtgcatgtgt gtaataaaga ttttctctat 2148181 tttacgaggt ttaatcgttg tatgtaaaat ttgatgctgt gtggcttccc cgcagtcaaa 2148241 aagccatacc gaacgccttt cttcaagcaa ttttaatgcc accgacgtta catttctcgc 2148301 cttggcgggg atgccggctc ccgtccctaa aaaaagtaat tccacgtttc cttcctccta 2148361 ctagaaccag atacctacaa gaatacagga tcaagcggaa aatgtgaatc ttgcctctga 2148421 aaagaacaat cctttcgtgc tagaaacatt ttttcagcat tctgcttaaa aaagggctta 2148481 aatgtttgct ttcgttgaat tttagattta aaatgaagga aatatacggg gtgtactaaa 2148541 ataaagcttc gaataaagtg aggtactttt agtgaaaaca aaccaacaac caaaagcagt 2148601 aattgtcata ttcggtgcaa ctggagattt agcaaaacga aaattgtatc cgtctattca 2148661 ccgtttatat caaaacggac aaatcggaga agagtttgca gtggtaggag ttggaagaag 2148721 accttggtct aatgaggatc ttcgccaaac tgttaaaaca tccatttcct catctgcaga 2148781 taagcatata gatgatttca cgtctcattt ttactatcac ccgtttgacg tgacaaaccc 2148841 tggttcttat caagagctaa acgtattgct taaccagctg gaagatacat atcaaattcc 2148901 taacaacaga atgttctact tggcaatggc tcctgaattc ttcggaacga ttgcaaaaac 2148961 attaaaatca gagggtgtaa cagctacaac cggctggtcc cgccttgtca tcgaaaaacc 2149021 gttcggccat gatctgccaa gcgcacaggc attgaataaa gaaatccgcg aagcatttac 2149081 ggaagatcaa atttacagaa tcgaccatta tctaggcaaa caaatggttc agaacattga 2149141 agtgattcga tttgccaatg cgattttcga accgctttgg acaaaccgct acatttcaaa 2149201 cattcaaatc acatctagcg aatcactagg cgttgaagac cgcgcaagat attacgaaaa 2149261 atcaggcgcc cttcgcgaca tggtgcaaaa ccatattatg cagatggttg cccttcttgc 2149321 aatggagccg cctatcaaat tgaacacaga agaaatccgc agcgagaaag tgaaggtgct 2149381 gagagcactg cgtcctattg caaaagacga agtggatgaa tactttgtgc gcggacaata 2149441 tcatgctggt gaaattgacg gtgtaccggt tcctgcttat acagatgaag ataatgtcgc 2149501 tcctgactcc aatacagaaa cctttgttgc cggcaagctc ttgatcgaca acttcagatg 2149561 ggctggtgtt ccattctaca tcagaaccgg aaaacgaatg aaagaaaagt ccacaaaaat 2149621 tgtcgttcaa tttaaggaca ttccgatgaa cctgtactac ggtaatgaaa acaacatgaa 2149681 tccgaacttg cttgtcattc atattcagcc tgacgaaggc attacgcttt acttaaatgc 2149741 taaaaagctt ggcggagcag cacacgcaca gccaatcaaa ctcgattatt gcagcaattg 2149801 caatgacgag ttgaacaccc ctgaagcata tgaaaaacta attcacgact gtcttcttgg 2149861 cgatgcaaca aactttgcac actgggatga agttgccctt tcttggagct ttgtcgactc 2149921 tatttctgaa acatgggcag caaacaaaac cttatctcct aactacgaat caggctcaat 2149981 gggaccgaaa gaatctgatg atcttttggt gaaagacggc ttacactggt ggaacatata 2150041 ataagaagaa aaaagccgaa aatgtttaca agcattttcg gcttttttac gctgaacaaa 2150101 ggtataacaa tctccttaat aacaaaaccc ccaaagctta agagcttcgg gggtttctat 2150161 tgattacttc atccattcag tatggaagat gccttctttg tcagtacgct cataagtatg 2150221 agcgccaaag tagtcgcgct gtgcttggat taagtttgca ggcagtacgg ctgtgcggta 2150281 gctgtcatag taggctaatg cgcttgagaa tgatggcacc ggcacacctt gggcaactgc 2150341 aagtgaaatc acttggcgaa gcgctccttg atagctttct acaatattct tgaaatagct 2150401 gtcaagaagc aggttgtcaa gctcaggctc gcgatcgtaa gcttctttga tcttctgaag 2150461 gaatgccgcg cgaatgatgc aaccaccgcg gaagatcata gcgatttcac catatttcag 2150521 atcccagttg tattcttcag aagcagcttt catttgggca aatccttgcg cgtatgaaca 2150581 gattttactc atgaacaacg cttttctgac cgcttcaatc agctcttctt tattttctgt 2150641 aacaggcttc acttctggtc ctgaaagaag tccgctcgct tttacacgct cttccttcat 2150701 agctgagata aagcgtgcga atacagattc agtaataatc ggaagcggaa cgcctaagtc 2150761 aagtgcgctt tggcttgtcc attttcctgt tcctttttgg cctgctttat caagaatcac 2150821 atcaacaagc ggtttgcctg tttcttcgtc tttttttgtg aagatgtcag ccgtaatctc 2150881 aatcaggtag ctatcaagct cacctttatt ccattcagcg aaaacttcat gaagctcatc 2150941 agcagaaagg cccagcacct gtttcagaat gaaatatgat tcagagatca gctgcatatc 2151001 tccgtattca attccgttgt gcaccatttt tacgtaatgg ccggcgccgt ccggaccgat 2151061 atatgtcgta caaggttctc cgtcaacttt tgcagaaatg gcttcaagaa tcggttttac 2151121 aagctcatgt gcttcttttt gtccgccagg catgatagaa ggtcctttaa gcgctccttc 2151181 ttctccgccg gaaacgcctg ttccgataaa atgaatgccg ctttcagcga gttctttgtt 2151241 acggcgctgt gtatctttat agtatgtatt accgccgtca attaaaatat catccttctc 2151301 tagatgagga agaagagatt gaattgtcgc atctgttgca gttcccgctt taaccattaa 2151361 taagattttg cgcggtgttt ccaaggattg gacaaattct tcaatgctgt aagtgccaac 2151421 aacatttttt ccttttgcct cctgtaaaaa ctcctcagtt ttactgcttg atctgttgta 2151481 aacagaaaca gaaaatcccc ggctttcgat atttaaagcc agatttttac ccatgaccgc 2151541 aagtccgata acgccgattt gttgttttga catattctaa cgtcccttct gcaaacgttt 2151601 aatcatttta aaatttaaat taaaataaaa tgatatttat aataaagaaa ttaccataca 2151661 ttcacccttt ttttcaagcg attcagcttt tcttttcatc ttgaaaaaaa tctttattaa 2151721 agcttgttcc ctttgttttg ctctcctctt tttttaacgt tgcccctttt ctgatcagtt 2151781 tggtaccgta ctttttattc agcttttcca tcatctgctg aatgggctca tccttcgcat 2151841 cttcattaaa gctgaacaaa tcgagctgtt tataggcctg ctctttttct actaaatccg 2151901 ttccggtaat gccaagcagc ctgacaggat ttttattcca atgtttaaaa aagaggtgct 2151961 ccgcttcttt caaaatgtca tttttttgat caatcgggtt tctcagcgta gtgcttcttg 2152021 tgatggttct ccaatccgca tatctaatca taataaaaag cttcgaagcc atgacttcct 2152081 tgcgctgtaa acggtcactc acagaagcgg caagctttct aaaaacgcct aacagctctt 2152141 cttcatcact ggaatcatgg gaaagtgtcg atgagttgcc gacgctttta aattcgtaaa 2152201 tgcgctccgg gtcaaccggc gcatggtgaa tgccatttgc tttattttta aggcgcggac 2152261 cgttgatgcc aagcaggcgc ttcagcgagt gttcatcagc tgcagctagc tctccgattg 2152321 tatggatgcc gagtcccttc agtttttccg ctgtcttttt gccgactccg tgcatctctc 2152381 caacaggaag cggccacagg atatcgggca cttgcctctt tcttaagatc gtaattccaa 2152441 gcggtttttt catatcagac gccatcttag cgagaaattt attcggtgca atccctatgc 2152501 ttgacgggag cagcagctct ttttgcagcc tgctttggat ttcttttgcc gtctctagag 2152561 cgcggctgct gtatggtgta tcggtcatgt ccatatagcc ttcgtcgatg gagacaggct 2152621 ccactaggtc agtatattca cgaagaatgg taaacatcgc tcgtgaagag tttctatagc 2152681 ggtcaaagtt cggcggaaga acgatgagct caggacaatg gcgcttcgct tgccaaaccg 2152741 gcatcgttgt tttgacgccg cgcgctcttg cttcgtagct gcatgttacc acaatgccct 2152801 ttcgctcctt tacgtttccg gcaactgcga ccggctttcc ccggagagcc ggatcatatg 2152861 ccatttcaac cgacgcataa aagctattca tatcaatatg gaaaataatt cggctctttc 2152921 ccggcataaa caaatctcct tttcggtcat tagacaacag cttgtacata tagtaaaatg 2152981 aagctattga atggatgtga tgacaatgtt tgtggaatcg ataaatgacg ttttattctt 2153041 agtcgatttt ttcacaatta ttcttcctgc tctaacggca atcgggattg cattcctctt 2153101 acgggagtgc cgtgcgggcg agcaatggaa atcaaaacga acagatgaac atcagacggt 2153161 ctttcacatt aaccgaacag actttcttat tattatatat catcgcatta caacttggat 2153221 acgtaaagtc ttccgcatga attcgcctgt gaacgatgag gaagacgccg gttctcttct 2153281 tttataaacc gcatttataa aaaggaggag aacaaaattg ttaaaaacat atcaaaaact 2153341 tttggctatg ggtatctttt tgatcgtatt atgctcgggc aatgctgcat ttgcagcgac 2153401 taatcaggtg ggaggcctca gcaacgtagg ttttttccac gattatttaa tcgaaccgtt 2153461 ttccgctctg cttaagggtg ttgccgggct gtttcacgga gaatacggac tctctattat 2153521 cctcgtaacc attattgtgc gtatagttgt attgcctttg tttgtcaatc agttcaaaaa 2153581 acagcgcatc ttccaagaga aaatggccgt tattaaacct caggttgaca gtatccaggt 2153641 taagttgaaa aagacgaagg acccggaaaa gcaaaaagag ctgcaaatgg aaatgatgaa 2153701 gctgtatcag gagcataata tcaacccgct tgcgatgggc tgtcttccaa tgctgattca 2153761 gtctccgatt atgattgggc tttattacgc gattcgctca acacctgaaa ttgcgtcaca 2153821 ctcgtttcta tggttcagtt tagggcaatc tgatattctc atgtccctta gtgcagggat 2153881 tatgtatttt gtccaagcct atatcgctca aaaactgagc gcgaaatatt ccgctgtccc 2153941 gcaaaaccct gcagcgcagc aatccgcaaa attgatggtg ttcatcttcc ctgtgatgat 2154001 gacgattttc tcgcttaatg tgccggcagc ccttccgctg tactggttta caagcggact 2154061 gtttttgaca gtgcaaaaca tcgtccttca gatgacgcat cataaaagta aaaaaacagc 2154121 cgctcttact gagtcggtga aataaaaaag caaccccgtg caaaaagccg gggttgtttt 2154181 ttgttacttg caaagtaccg cgccaaacag tcttgtttat catggctgaa gcagaaatgg 2154241 ccatcctaaa aaatagccgt atcgtttaaa aagaaggaaa tcgggaatac ctttactcac 2154301 ctccaaccga aaggagccta tacgttgacg gaacgctttc agcaaaaaaa tatttctgta 2154361 cctgatggaa tctggatcat gagacaaacc tggaatgatg tcttatttgc tcactggcct 2154421 gttgatgttt ctatccttcg cgctttggta ccgtccgttt tagaattaga tacatataac 2154481 gggcaagctt ggatcagcat gcttcccttt atgctcacga acctgagggc gcgttatctc 2154541 cctgtcattc ccggtgcgcg tgcatttcct gagcttaacc tccgcaccta tgtcacgtat 2154601 aaaggcaagc ccggcattta tttttttagc ttagatgccg atcatcgtct ggcggtcctt 2154661 ggcgctcgca cattctttca tctgccttat ttttacgcgg atatgaagtc cgaaaaaaac 2154721 ggtgatgcca ttgactatgt cagcaagcgg aaaaatgaca aagaagcagc attccacgcc 2154781 gcataccggc caatttcagc gccttttaca gcagaaaagg attcgctcga ttactggctg 2154841 acagaacgat acaggctcta caccacttat cgcaataagc tctattacga agacatccat 2154901 catcatccgt ggctgctgca aaacgccgaa gcagaaattt cagtcaatac ggtgactgat 2154961 gctcacggta ttacattgcc ggagtcagac cccttgcttc attatgctaa aaaacaggat 2155021 gtgttatttt ggccgcttag gaaatggagc taaaaaaacc cgatgcggga aatcgcactc 2155081 gggttttctt tttttatttt gccgcctctt caataatggc aacaaccatt tctgccgttt 2155141 taacgagctc ttcgatcggc attttttcat tttttgtatg gatttgctca taaccgacag 2155201 caagattgac cgtcgggatg ccatgaccag cgattacgtt cgcgtcgctt ccgccgccgc 2155261 tcgtttgcag ctcgcttgga cgtccgattt tagcagccgc ttttttcgcg atttcaacaa 2155321 cttggtcgcc gtcttgatat ttaaagcccg gatacataac ctcaatttcg acttctgcgc 2155381 gtccgcccat atcagcagct gcctcttcaa aagcagcttt cattttttga acctgagctt 2155441 ccattttctc aggaactaaa gagcgcgctt cagcaagaat atgaacttcg tcgcacacaa 2155501 tgtttgtttg tgtgccgcct tcaaaccggc cgatattagc tgttgtttct tcatcgatac 2155561 ggcccaatgg catttttgag atggctttgc tagcgattgt aatcgctgaa atgccttttt 2155621 caggttcaac cccggcgtga gcggttttcc cgaaaattgc cgctcttacc ttcgcctgtg 2155681 tcggcgcggc cacaatgata tttccgactt ttccgtctga atcaagagca tagccgtagg 2155741 atgcagtgat catagaacgg tcaagcgcct tcgctccgat cagacccgat tcttccccta 2155801 ctgtgatgat gaattcaatc gtgccgtgtt caatattttc ttctttcagc accttaatcg 2155861 cctcaaacat tgcagccaat cccgctttat catcagcacc taaaatcgtc gtgccgtcag 2155921 ttttgacgta accgttctct acaactggtt ttacgccgtt tccgggtaca actgtgtcca 2155981 tatgagatgt aaaatagatc gtatctgttt gttttgtccc ttttagcgtg caaatcaggt 2156041 taccggctcc gtggcccgtg atatccattg tatcgtcttc tttaacgtcc acacctaaat 2156101 cagaaaattt tcgtttcagc actttgcaga tttcagcttc gtgctttgtt tctgagtcaa 2156161 tttggacaag ctctaaaaat tcttccagca ggcgtttttc attcaccatt tgtaagtccc 2156221 tccatattaa agcggtatgt taccgtgctt ttttttcggt ctctcttctg tcttatgtgt 2156281 aagcatatga aaagcttgaa tcagtcttcc ccttgattct tccggcaaaa tgatgtcatc 2156341 gaccattcca caagcggccg ctttgtatgg gccggcgttt tgctttttgt attcagcagt 2156401 tttttcgcgt ttcgtctttt gcgggtcagc tgaagctttg atttcctttt catacaaaat 2156461 cgatgccgca ccttctggac ccatcactgc gatttcagca ttcggccatg caaacacaag 2156521 gtccgctccg atcgctttgc tgttcatggc cacataggcg ccgccgtacg cttttctaat 2156581 gatgagtgtg acttttggga cagtcgcttc agcataagca aacaataatt ttgctccatg 2156641 cctgatgatt ccgttgtgct cttgctgaat acccggcaga aaccccggga catcttcgac 2156701 agtcaacagc gggatatcaa atgcgtcaca aaaacggatg aaccttgctg ctttatcagc 2156761 agcgtcaatc gtcaggcttc ccgccagatg cttcggctgg ctcgccacga tgccgattgc 2156821 tttttcaccc agccttgcaa acccaatgac aatgttcttc gcaaaaaatg gctgaatctc 2156881 aaaaaaagac tgcgggtcag ccagctccct aatcaccttc cgaacatcat aaggctttgt 2156941 cgtatcagca gggacaagac ggtttaataa cggtctggac gcctctttct ctggcttcgg 2157001 ctctgttgtc cggccattca gcggcaaata agacagtagt tttctcaccc ctgtcagaac 2157061 ctccttctcc gtatgcccgg aaaagtgggc gtttccgctg acggcattat gtatccccgc 2157121 tccgcctaag ctctccgcat caacctgttc ccctgtcact ttttcaatca ccttcgggcc 2157181 ggtaataaac atccggccag tctgttcagc cataaatata aaatctgtga gtgccggaga 2157241 atatacagcg cctccagcgc acggccctaa aataaccgat atttgcggaa tgactccgga 2157301 atataagacg tttcggtaaa atatgtgacc gtatccatct aatgataaca caccctcttg 2157361 aattctcgca ccacctgagt cattcagccc gataatcggc gccttatttt ttgctgccag 2157421 atccatcaaa gcgcagattt tcctggcatg ggtttcgcca agcgcccctc cgtacactgt 2157481 gaagtcttgc gcaaatacat aaactgagcg accgtcaatt gtgccgtacc ctgtcacgac 2157541 cccatcccct aacatgcgct gttctcttgt taacacttga ctttccatga aggggtgtaa 2157601 ttcgataaag ctgtcctgat ctagaagaaa tatgatcctt tcccgagcag tgagcttgcc 2157661 cttttgccgc tgctgagcca gcttttcccg tcctccgcct tcttctgcct gcttgcgttt 2157721 cgtgtaaaaa tgatccatgt gctcattcat gctcattgtg ttggtctcct ttcggttcac 2157781 aaagctctac aagaacaccg tttgtttccc gaggggaaat aaacgcgatc tttttcccgt 2157841 tcgctccctg tcttggaaac ctgtcaatca attgaacatg ctgatcagac aatgcttgaa 2157901 gctgttcaga taggcagttg cacaaaaacg caatatgatg cagtccctgc cctttcttct 2157961 ccaaaaataa atggacgggg ctgtcagctg tcaacggctc tatcagctca agtttgacgc 2158021 taccagcttg aaaaaaagca acattcacct tttgctcttc aaccgtttct tgatgaagaa 2158081 atgcaagccc caatacattt tcataaaagc ttcttgcatc ttttatcgaa aaaacggcta 2158141 tcccgatatg gtcaagcctg ttcattttca tccctgcttt cgctaataga tatcgcttgt 2158201 ccgcccattc aaaacacgct aaaatataga cagattgttt aaggagtgaa aatcatgtct 2158261 caaaaactga tgaaaagcgt tttgatcgtg attttgggag tttttattct ttcaactgta 2158321 ctctcaggaa tcgtcatgtt tctataacga taaaaaagca ggcgccttat tcaatgggaa 2158381 tatcctgctt ttttatcaga gctttatgct cgatggcaat ctcctcaaaa gagcggttgt 2158441 cgtccgtgat cagcactctc gttcctactg gtatcgtttg aaacaaatga acaacctcat 2158501 cgttatgcat acgtatacag ccgttagaca caaattttcc tactgattcc tctcggtttg 2158561 tcccatgaat tccataaatc cgcccgtccg ttcctttcgc gtcaaatccg atccatcttg 2158621 ccccaagcgg gttatcagga gatccccctt caatattttt ctttctgtag taaggatttt 2158681 ccgcttttac cgttaccgaa aactctcctt caggcgtcaa atcatctgtt tttccagtcg 2158741 ccacactata cacgccttct actttgttgt cgaggataac agcaagttca tttgttcgct 2158801 tgttgacaat aacatacgga tcacccggca gcggattttc gccgagcggc caaatcggtg 2158861 aaatcatcat gaaaatcgaa cataagaaaa aacgcataag ctcctccttt ttcattaggt 2158921 tgaccaatga aggaagagct catgcgaatc atccgagtga tttttgcgct tttattcctt 2158981 taaaataact tttaatcact aaatattgtt ccatttcgcc gagaagatgg aagagagcgg 2159041 ccctcgcttc aaattcctct ctagtcgcag gaagcggcat ctcctcaaat tcttttctca 2159101 tgtcagcaag tcttttcaga aatttgtatg ctgtattccc agggtgtatc gcctcccgca 2159161 aatcatgaat aaattcagcg atcatttttc cctgatctac cgtgatggag atcgatgtca 2159221 ctttagggag aaggcgttcg ataatttcaa attgcttttc tctcatttta aaataatgat 2159281 aatgcagatt ttcataacgc aaaatgtggt tttgcacatc tcgatatgcc aggtttttag 2159341 cctccgtaat gagctggtgc gtttccggaa tttcttttcc tgaccaatct tgctcaccag 2159401 ttaacaaata ccgttcgatt tctgcaaaaa tgacagcaaa gttatcctct atctttttgc 2159461 ggtaggcaat cagtttccgg tcaagactag gcatatacaa gttcatcaat agagcgacgc 2159521 cgatgccaac cgtaatcagc tgaacttcat tccagatgaa agtaggcgta atgccgccgg 2159581 acatgtataa atgaaggata ataacagaac tggtgacgat accctcgtta atttttaaca 2159641 gaaccgttat cggaatgaat atcaaaagaa gcgctccgat cacaaacggg tggtagccaa 2159701 taagctcgaa aaagagataa gaaaaagcaa ttgccagaca gcatgccgaa aagcgggccc 2159761 atgaggcctg aagcgaccgt ttttgtgtga tttgtatgca caaaatggtg atgattcctg 2159821 ctgatgcgaa gttttgcaaa tgcaataact ggcttatata aatagccaaa gctgttccaa 2159881 gcgcggtctt tattgtgcgg taaccaattt taaacatgtc ggactccatt tctatttgtt 2159941 tcttcaataa aaaagaagag gcggccagcc ttcttctttt ttatattcta taatattttc 2160001 tctaaaaagt cctgcgctct tttggatttt ggcgacataa aaaattcctt cggattgccg 2160061 tcttcgacaa tcattccttg gtccataaac agcacacggt ctgccacttc ttttgcgaag 2160121 cccatttcat gtgtgacaat caccatggtc atgccggttt cgaccagctc tttcatcacc 2160181 tgtagcactt ctttgaccat ctctggatca agggcggagg tcggctcgtc aaacagcatg 2160241 atgtccggat tcatcgcaag agccctggca atcgcgacac gctgtttttg tccgccagac 2160301 aaacggtttg gatagtcatt tcgcttttca aacaaaccga ctttgcggag caggtcctca 2160361 gctttctcct gtgcagcctg ttttgattct ttttttacat tgacaggcgc gtacatgatg 2160421 ttttcgagaa ccgttttgtg cggaaagaga tgaaaatgct gaaaaaccat cccgatgttt 2160481 tcccggacct ttaatgtgtt ggttttcggc ttcgtaatct ctgtgtcttt tattgtaatg 2160541 gttccgccgt taggcttttc caacaggttt aaacagcgta agaacgttga tttgcctgag 2160601 cctgaaggac cgatcacggc aacaacctca ccctcagcga ttgttgttga aatgtttttt 2160661 aatacttcgt gtttcccaaa tgattttgac agcttttcaa ccttaatcat tggatttcag 2160721 cttcctttct acagccttgc cgataaacgt taaaatcagg acaagcacat aataaatcaa 2160781 tcccgcgata atgagcggct caaggtaatt gtaagtggcg gcgccagctt gatatgcgcg 2160841 tctcatgaca tcaccaagcc cgatgacggt gacgatcgcc gattcttttg ttaacgtaat 2160901 taattcattc acaattgcag gtgatatatt tttgaaggcc tgcggcagca gcagatcctt 2160961 catcattttt ccatacggga caccgagtgc aacagcagct tctttttgcc ctttatcaat 2161021 ggcattgatt ccggctctga taatttccga tacataagcg gcggaattca aagacaatgc 2161081 gacaaccgca gcccaaaact ggtcaatttg aaatccgagc agctgaggaa ggccaaaata 2161141 gacaatcata agctgcagca ctaaaggcgt gcctcggaac actgatgtat aaaaatcagc 2161201 gatccagata aacgggcgga atgtgctgat cttgcataag cttagcacaa taccgagtat 2161261 aagtccgata atagcagata caacaacaat ttttaatgta attgccaagc cttctaatat 2161321 aaaaggaatt tgggggatcg ttgctgaaaa atccaaattc atagcctttg tctccttttc 2161381 ttacaggaaa aaagtttcct attcaataaa aaggctcaac gaaaaagttg agccgctttt 2161441 ttttacttct cgccagtgaa ccattttttc ttcaatttct caagctctcc gttatcttcc 2161501 atttccttga gcgctttatt gaatttgtct gtcagttcac tgtcctttct gaaagcaatt 2161561 gctgaaccgg cttcttccgc tttcgcatca ggaatcacaa agccttgcag gtcatcattt 2161621 gatttgaaat acccttctgc aacaatgtct tcaataatcg cggcatcgaa gcggtcagat 2161681 ttgatttcct gcaccaaatc agaaattctg ttgcggtctt ctgttttaaa accatattcc 2161741 ggagaaagct ctttcccctt ctcttcctga atagagccaa gctgaacgcc aactgttttt 2161801 cctttcaggt ctttcaaaga ttgaatgccg ctgtcttttt tgctgacaat catatggttc 2161861 gctgtgtaat acacatcgga aaaatcaact tgttttttac gctcaggcgt tggtgtcatt 2161921 cctgacagaa cgagatccac ctgttttgat ttaagcgctg taattaagct gttgaagtcc 2161981 atatcctgca cttcaatttc atagcctgcc ttctttgcca gagcttttgc cagctctaca 2162041 tcaaagccga caatattatc tccttcttta tattcaaacg gtttgtaatc cgccgaagta 2162101 cccataatta attttttctt tccgctttct gaacctgaat tgcttgagcc gcacgcagtt 2162161 aatgcaaagg tgatgcaagc agccacaagt aataagagcc attttttcat gatccatttc 2162221 ccccgtattc attacttttg gtgtatttga atatttattc gttaatttgt attttaaaca 2162281 gtttctcatt tttatgcaat actattttta aaaattatct ttaggcttat ctttccagtg 2162341 atctcttctg atattactag ataaaaatta aatcgctgta caatccgatt gaataatccc 2162401 ttaatattta ttcatatatc cttggaaatt tatgcacaaa aaaacccggg ctgctttgag 2162461 catccgggtt gttcgtctta tacttcttca caatattctt caaaggcttc ctgcagcttt 2162521 gccactacag ccatcggctc atggccttca atttcatgac gctctaccat tttcatgatc 2162581 tttccgtctt tcaaaatcgc aaaggacgga gaagatggtg gataaccttc aaaatagtca 2162641 cgcgcacgcg ctgtcgcttc tttatcctgt ccggcaaaaa cggtgacgag ctgatcaggt 2162701 cttttatcat agtgaacgga atggtaggct gccggtcttg caattcctcc ggcgcatccg 2162761 caaacagagt ttaccatgac gagcgtcgtt ccttttttcg taagtgcctc atccacctct 2162821 tcggctgttt taagctcggt gtatccggca gctgttattt cttgtctcgc ttggcggaca 2162881 atatcattca taaataaatt aaagtccatg ttcaatgaag acctctcctt tttcatcatc 2162941 tgttcttatg atagcaagga aacgtccata tcggcaaatg actttgcttc gccgtgcact 2163001 ttttttgctc ttcgtttact gcttacagaa aaaggggatt atataaccag aagtaaaata 2163061 aaggagcagt tgtatatgag ccaccggaaa gcgttactga ttcataacgg aaatgccggc 2163121 aacaaaaata tagaaaaagc acttggtgct gtggtgccgg ttttatctca ccatttagat 2163181 gaggtgatta ttaaacagac aaagaaaaag gatgatgcgt atcatttttg ccgatccatt 2163241 gatgattctg tcgacaccgt cttcattctc ggcggcgacg gcacgatcca tcaatgcata 2163301 aatgctatca gcgctctaga aagaaaaccc gctgtcggaa ttttgcccgg cggcacgtgc 2163361 aacgactttt caagagtgct tggcatccct caaaatcttg caaaggccgc ggaagcactt 2163421 atggcgggaa aaaaaaccag cgtagacgta tgtcagatga atgaccgtta ttttttgaat 2163481 ttctggggga tcggcttaat tgcagaaacg tcgaatcaaa tcaacgaaac ggaaaaagca 2163541 ttattgggaa aaatcagcta ttttacaagt gccttgcgaa ccgtctcatc tgctgcatcg 2163601 tttccgatga cattaaaaat tgatggagaa gaaattaaag aagaagccgt tatgctgctt 2163661 gtgatgaatg gccaatacat tggaacgaat cgaattcctc tgcccgatgc cagtattgaa 2163721 gacggcttac ttgatgttct catatgccgc aataccaacc tcaccgcgct gcgggagctg 2163781 atgagcatgg aacaaggctc aattgatcgt tttactggag agttgtccta tgtccaggct 2163841 tcccgtatcg agattgaaac agacactgcc aaaaaggcgg atatggatgg agaagtttat 2163901 acacatacac ccgcagtcat tcaggtcctg ccacagcata tcgacatgct tgttcccgca 2163961 aatgaataac tgtcataagg ctttagaaag attttgcaaa tccgttgact ctcccctagg 2164021 aggaggtctt acagtataag ggatacacac ttgaaaaagg ggaagtcata tggagaagaa 2164081 aaatattacc ttaactatat tattaaccaa tttatttatt gcttttttgg ggatcgggct 2164141 tgtgattcca gtaacgccga ccattatgaa tgaattgcat ttatcgggga ccgcggtcgg 2164201 ctatatggtt gcctgcttcg ctattacaca gctcattgtc tcaccaatag ccggacgatg 2164261 ggttgatcgc ttcgggcgca agatcatgat cgtaatcggc ctgttgttct ttagtgtgtc 2164321 ggagtttttg ttcggcattg gaaaaacagt tgagatgtta tttatctccc gtatgctggg 2164381 cggtatcagc gcagccttca ttatgcccgg ggtcacggct tttattgcag atatcacgac 2164441 cattaaaaca cggccaaaag cgctcggtta tatgtcagcc gctatttcaa caggatttat 2164501 tatcggcccc ggcatcgggg gatttttagc agaagtccat tcccggctgc cttttttctt 2164561 tgcggcagct tttgcactgt tagcagccat tttatcaatc ctcacgctgc gcgagccgga 2164621 acgaaaccct gaaaatcagg aaataaaagg acagaagaca ggctttaaac gaatttttgc 2164681 ccccatgtat ttcatagctt ttctcattat cttaatttcg tcttttggtt tagcatcatt 2164741 tgaatcttta tttgcattat tcgtggatca taaattcgga tttacggcca gcgacattgc 2164801 cattatgatt acaggaggag cgattgttgg cgccattacg caagtcgtct tattcgaccg 2164861 cttcacaaga tggtttggcg aaattcattt aattcggtac agcttaattc tctcgacgag 2164921 tctggtattc ttgctgacaa cggtacattc atatgttgcg attctgctgg tgacagtcac 2164981 cgtatttgtc ggatttgatc tcatgcggcc tgcggtaacg acttacctgt caaagattgc 2165041 gggaaatgaa caggggtttg ccggcggtat gaattcaatg tttacaagta tcggcaatgt 2165101 attcgggcct attatcggcg gaatgctgtt cgatatagat gtaaactatc ctttctactt 2165161 tgcaacggtc accttagcca tagggattgc actgaccatt gcttggaaag cgcctgcaca 2165221 tcttaaagcc agcacgtgat aagaagcgca ttctttgtgt actgcaaaga atgcgcttct 2165281 tctttatact gatgatagaa ggagtgatgg catgaaggaa tcgtattact caattgggga 2165341 agtatcaaaa ctggcaaacg tgtcgataaa agcgctccgt tattacgata aaattgattt 2165401 atttaaacca gcctacgtcg acccggatac cagctaccgc tattatacag attctcagct 2165461 cattcatctg gatttgatca aatcattgaa atatatcggc acacctttag aagagatgaa 2165521 aaaagcacag gacttagaga tggaagaact gtttgctttt tatacagagc aggagaggca 2165581 aatcagggag aaattagact ttttatcagc cctggagcaa accatttcat tggtgaaaaa 2165641 gcggatgaaa cggcagatgg aatatcccgc gctcggtgag gtgtttgttt tagatgaaga 2165701 agaaatacgg atcattcaga cagaggcaga aggaatcggg cctgaaaacg tgctcaacgc 2165761 ctcctacagc aaattaaaaa aatttatcga gtcagcagat ggatttacga acaatagcta 2165821 cggcgctact ttctcttttc agccctacac cagcattgat gaaatgactt accgtcatat 2165881 tttcacacct gtattgacga ataaacagat ttcatcaatt acgccggata tggaaatcac 2165941 aacgatccct aaagggaggt atgcgtgtat cgcgtataat ttttcgcctg aacattattt 2166001 tctcaactta cagaagctta tcaaatatat cgcggaccgc caattaacag ttgtcagtga 2166061 tgtatacgag ttaatcatac cgattcatta ctccccgaaa aaacaagaag aatatcgagt 2166121 cgaaatgaaa atacggatcg ctgaataata aagcatagaa aaagagcatt ttttgaaaca 2166181 aaacttcaaa aaatgctctt tttgcttatt tagtaaacag atgtcttctc gtcaatcgat 2166241 tctaaaattt gtttcactcg tccgaggaat cgtccgcaca cgagaccgtc aagcactctg 2166301 tgatctaatg acaggcacag attaaccatg tctctgacag caatcatgcc attgtccatg 2166361 acaaccgggc gtttgacgat ggattctact tgaagaatcg cagcctgagg gtagttgata 2166421 atgcccatcg actgaacaga cccgaacgaa cctgtgttgt tgacggtaaa cgtgcctccc 2166481 tgcatgtcat ctgcagtgag ttttccgtct cttacttttt tagctaggcc ggtaatgtct 2166541 ttcgcaatgc ctttaattgt tttttcatca gcgtttttaa tcaccggaac aaataaagaa 2166601 tcctctgtgg caactgcaat tgaaatattg atatcctttt tctgaataat tttgtccccc 2166661 gcccacatgc tattcatttg cgggaattct tttaacgcct gagcgaccgc ttttacaaaa 2166721 aaggcgaaga acgttaaatt aaagccttct gtcttcttaa aagaatcttt tatactgttg 2166781 cgatatgcaa ccatatttgt gacgtcgact tccatcatcg tccaagcatg cggaatttct 2166841 gttttgcttc gcttcatatt ggaagcaatt gcttttctta cacctgtgac agggatttct 2166901 ttatcaccgg ctgcagacgc aggatatgac gtctcttctt ttggctcagg ttttgatgca 2166961 gacttcggtg caggagctgc tgttttcagc tcctcaggat tctgttcttg cacgccgcct 2167021 gtttcaatta agcgctgaat atcttttcgt gtgatgcgcc cgccggcacc agttcctgtc 2167081 acttgatcga ggtcaatgcc gtgctctccg gccaaacgga gaacagctgg cgagtagcgc 2167141 tttttattgg gctgatcggc tgctccagca ctttttgcaa cagggttctc agcggcttct 2167201 gatgctgctg gctgttcttg tttttgttca gccggattcg cgccttctgt ttcaattttg 2167261 caaatcattt ctccgacttg cagggtttgg ccttcttctc ccacaagctc tgttatcgta 2167321 ccagtaaaag aagacggaac ctctgcattt accttatctg tcatgacttc cgcgatcgga 2167381 tcgtatttgt tcactttatc accgggggcg acaagccatt tgctgatcgt cccctctgtt 2167441 acgctttctc caagctgcgg catcgtcatt tgttcaattg ccatgattgt atcctccctt 2167501 acgtctttaa aactccgcta attctctcat cgccgcttcc actttatcag ggttgaccat 2167561 aaagtatttt tccattgtcg gcgcataagg catagccgga atatcaggac ctgcaagccg 2167621 tttgatcggc gcgtctaagt cgaacagaca atgctcggat ataattgcgg ctacttcgct 2167681 catgatgctg ccttcttttg tatcttctgt gaccaaaaga acctttccag ttttggacgc 2167741 agcttcgatg atggcttctt tatcaagcgg gtaaactgtt cttaaatcca ccacatgcgc 2167801 tgaaatgcca tctttttcga gacgttctgc agcttgtaag gcgaagtgga cacacaggcc 2167861 gtatgtgatc actgtgatgt cgtcgccttc cctttttacg tccgccttgc cgattggcag 2167921 gacataatca tcagccggaa cctcgccctt tatcagacgg tatgcccgct tgtgctcaaa 2167981 aaacagcacg gggtcttcgt cacgaactgc ggcttttaag agccctttcg cgtcatatgg 2168041 tgttgatggc atgacaattt tcagtccggg ctggttggcg aaaattgctt cgactgattg 2168101 agaatgatac agggctccgt gcacgcctcc gccgtatggc gctctgacga caatcggaca 2168161 gctccagtca ttgttgctgc ggtagcggat tttagccgct tcagaaataa tttggttgac 2168221 tgccggcata atgaaatcag caaactgcat ttcagcaatc ggtctcattc cgtacattgc 2168281 cgctccgata ccgactcctg cgattgcaga ttcagcaagc ggcgtatcca taacgcgctc 2168341 ttccccaaat tgttcataga gtcccgctgt cgctttaaac acaccgcctt ttcttcctac 2168401 atcttcccca aggacgaaaa cgcgagaatc tcgttccatt tcttctttca tcgccaaatt 2168461 gattgcatca atatatgaca ttactgacat ttgttcttcc tccctacttc gcataaacat 2168521 aatcaagcgc tgactcagga gctgcatatg gggcgttctc cgcttcatcc gtcgcttcat 2168581 ttacgattgc cataatttca tccagcatgg tttgttctat ctcatcggac agcaggcctg 2168641 tttcctttaa gtaagcttga taagtaagca ggggatcact ttttttcgct tcctctactt 2168701 cttcacggcc tctgtagctg ctgtcatcgt catcactgga atgtggtgta aggcggtaag 2168761 aaatcgtttc aattaatgtc gggccttctc ctctgcgtgc cctttcgcgt gcttctttaa 2168821 ccgcttgata aacttccagc ggatcatttc cattcacagt tacgccaggc atcccatagc 2168881 ctatggcacg gtcggaaatg ttctcacatg cgacttgctt atcgtaaggc actgagattg 2168941 cgtatttgtt gttttcacac atgaaaataa ccggcagctt atggacagcg gcaaagtttg 2169001 ccccttcatg gaaatcgcct tggtttgaag acccttcccc gaatgtaaca aaggctgcga 2169061 tatccttttt ctccatacgt cccgcaagcg caataccgac tgcgtgcggc acttgcgttg 2169121 taaccggaga tgatcccgtc acaatgcggt ttttcttttg tccgaaatgt cccggcatct 2169181 ggcggcctcc tgagttcgga tctgctgctt ttgcaaaccc ggacatcatt aagtcctttg 2169241 ctgtcatgcc aaacgcgagc acgacaccca tgtctctgta gtacggcaat acataatcca 2169301 tttcacggtc aagtgcgaaa gccgctccta cctgtgctgc ttcctgtcct tgacaagaga 2169361 ttacaaatgg aattttgcca gaacggttta acagccacat tctttcatcg atttttcttg 2169421 ctaacagcat ggttctatac atatcaacgg cttcctgatc agtcagccct agtgcttgat 2169481 gtcggtttgt actcattcaa gcccctcctt tatgctttta aaaatgaatg gctttgccat 2169541 ctgcggcaag cgcagcttct ccaattgctt cagaaagcgt tggatgcggg tgaatcgttt 2169601 gcccgacctc ccacggtgtt gcgtccagca ctttggcaag acccgcttca gaaatcatgt 2169661 cggtgacatg cgggccaatc atatgaacgc cgagaatatc atctgtatct cggtcagcca 2169721 cgattttgac aaaaccgtcg ctttcaccgt atacaagcgc ttttccaatc gccataaatg 2169781 ggaacttgcc gattttgaca ttatgcccgt tcgcctttgc ttcgtcttcg gttaagccga 2169841 cactggcagc ttcagggctt gagtaaatgc acttcggcac aagcgtcgga tcaagcggat 2169901 gcggattgag acctgcaaaa tgctcaacag caataattcc ctcatgtgaa gcaacgtgag 2169961 ctaactgcag gccaccgatt acgtctccga ttgcataaat atgagattcc ttcgtttggc 2170021 agctttcatt gactgaaatc atgccatttt cagtaacaat atcggtgttc tctaggccga 2170081 tgccttcgat atttgcctgt ctgccgatgg aaacaagcat tttctcagca gaataggtaa 2170141 cggtttctcc gtctttttcc gcttgtatgc tgatatcgtc tgatgttttt gtcattgtgt 2170201 caggcagcac ttttgcccct gttatgaact ggatgccttt tttcttaaga agactttcca 2170261 tttcttttga aatctctaga tcttcagtcg gcaatatgcg atccgcgtat tcaataaccg 2170321 ttaccttaac gccaaaatca tgaagcatag acgcccattc gataccgata acccctccgc 2170381 cgacaatgat gattgactgt ggcagctcct ccatttggag cgcctcatct gaagtcagta 2170441 cagacttacc gtccacttca agacccggaa gcattctcgg tcttgatcct gttgcaatga 2170501 tcacttgttt cgggatcagc atgtcatttt cttcgccatt tccccgctca acagaaattg 2170561 ttcccggcag cggagagaag attgacggtc caaggatacg tccatatccg gtgtacacgt 2170621 caatttttcc ttttttcatt aaatgattta cacccgctgc aagcttatca acaacggctt 2170681 gcttacgctg ctgcactttt tcaaagttga gggacacgcc agccgtttcc actccgaatt 2170741 gatcggcttc acgagctgtc cggtatacct ctgcgcttct aagcagcgct ttactcggga 2170801 tacagccttt atgcagacat gttcccccga gtttttcctt ttccacaacg gctgttttta 2170861 agccgagctg agcggctctg atggccgcaa cataaccgcc ggtaccgccg cccagaatga 2170921 ctacgtcata ctcagttgcc atggtgactc actcctgtct gtctattcaa tacgatattg 2170981 tttggattgc tcttcgccct gcaatactct tagcgcccct tgggcaagag actgcagttc 2171041 attttcaccc ggataaacta aaacgtctga aatccaatct atgtatgatc tgatagcaga 2171101 aacaaagctt tttccgtacg caaggcctcc cgtcagcaca atcgcttcaa cttcgccttt 2171161 taacgccgcg ctggctgccc cgatttcctt tgctacctga tatgccatgg catcataaat 2171221 gaagcgggct ttttcatcgc ccccttgaat catctgttcc acttttactg catcatttgt 2171281 accgagatag cctaaaagtc cgccggtgcc aacaagcttt ttcatgattt cttcttttgt 2171341 atattcccct gaaaaacata gatcaacaag atctcccgca ggcactgttc ctgctcgttc 2171401 aggactgaat ggtccctcgc cgtgcaggcc gttattgaca tccaccactc gcccgcggtc 2171461 atggacgcca attgtaatac ctccgcccat atgggtaata atcattttca tgttctcata 2171521 tcgtttgcca agggaggctg ccgctttacg agcgacagct ttttggttta acgcatggaa 2171581 aatgcttttc ctttcaattt caggcatgcc tgaaactttc gcaagcactg acatttcgtc 2171641 tacgacaaca gggtcgacga tatacgaagg gatattcagg ccgtcagcga tttcccgcgc 2171701 gataatgccg ccgagattag aagcatgctg accggcgtag ccgcttttca aatcctcaat 2171761 catctcatca ttcactacgt aggtcccgcc ttcaattggc cggagaaggc cgcctcttgc 2171821 gcagactgca tcaaactttg aaatattgat tccctgttca tgaagcgttt cgagaatatg 2171881 gtttttacga aattcatact gatcaataat tcggtcaaat cgctgcagct cttctatgtt 2171941 gtgtctcaat gttttttcaa aaatgcttct ttcgttatga aaaacaccga ttttcgttga 2172001 agttgagcct ggattaattg tgagaatgcg tttttcgtca tgtagcactt tcataacctc 2172061 cagatcaatt tcttaacgtc tgcttaatac actgtggccg ttttgcaaaa actggcttct 2172121 tgagcggcgc atgcgttcaa tccgttcctc tgctaagcgg tcagccgcta aatatgcagg 2172181 aatgccgtca cgctgagaaa tctcaagtac acgctcgata ttgccgtaaa tgccttcaac 2172241 ttttttcaat gcacgttctg cattatagcc gtaaagctca tctgccacgt tgatgacacc 2172301 gcccgcgtta atcacgtaat ccggtgcata aacgatgccc atttcgtgaa tttgatcacc 2172361 atggcgtgtc tcttttaatt ggttgttagc cgcacctgcg atcactttcg ccttcagctg 2172421 tttaatggtg tcgtcgttaa tagtcgcacc aagggcacac ggcgcataaa tatcgcagtc 2172481 ttgtgaataa atgtcatcag gatctaccgc acgggcgcca aaatcttcaa ctgcacgctg 2172541 tacagattgt ttgttgatat ccgtaacgat taagtttgct ccttcttcat gcaggtggcg 2172601 gcaaaggtta taggctacgt tcccaacacc ctgtacagca atggtttttc cttcaagaga 2172661 gtcggttccg aaagcagctt tagctgctgc cttcattcct ctgtacaccc cgtacgctgt 2172721 gactggggac ggatttccag aagagccgaa agcaggagaa atccctgtga catagtctgt 2172781 ctcatcatga atgatatcca tatcctcgac cgttgtgccc acatcttcag ccgtgatgta 2172841 tctgccattc agtccttgaa tatagcggcc aaacgcgcgg aacatttcct catttttgtc 2172901 tttgcgcgga tcgccgataa tgactgtttt tccgccgcca aggtttaagc ctgccgccgc 2172961 gttcttatag gtcatgcctc ttgccaatct gagcgcatct tcaattgccg cttcttcatt 2173021 ttcatatgtc cacattctcg ttccgccaag cgccggacca agcgttgtat catgaatggc 2173081 gataatcgct tttaatccag attgttcatc ctggcagaat accaattgtt cgtaatcgta 2173141 tttctccata tatttaaaaa gttccatgtt cgttcctcct aatgtgtgta ttcttcagat 2173201 gcgcatattg ccagcgcaat ggaatacagt ttattttcag cagagtccgc tctgcttgtt 2173261 aaagcaatcg gtgcttttgc tcctgtaatg acagccgcca cgctggcctt ggcaaaataa 2173321 atcagtgatt tatataaaat attgccggcc tcaattgttg ggacgagaag gatatctgcg 2173381 ttgcccgcta cgtctcccga aatttttttc tgggccgcgg caatttgtga aactgcgtta 2173441 tccaaagcaa gcggtccatc aacaatgcag cctttgatct ggcccctttt gtacatttga 2173501 gctagagcag ctgcattcac ggtcgcttcc attttagggt tcaccgtttc gaccgctgca 2173561 agggcagctg cttttggcat attgttcccc actgcatggg ccacatgaac ggcattttgc 2173621 aaaatctgcc ggagctcttc cagcgaagga gcaatattca ttgccgaatc tgtcacaaac 2173681 atcagccggt caaaatccgg tatatcgaag acagccacgt gagaaaggac acttgctgac 2173741 cgaagcccct cctgtctgtt caataccgct ttaagcaaaa cagaagtcgg cacattgcct 2173801 ttcattaaaa cgtccgctgt tttatgatgc acagcacgaa ccgctaattt cgccgattcc 2173861 tcaggagtat tggcatggac gatttccact tgatgccctt gcatggatga tgtcagctcg 2173921 ttcagttttt tgctgtcgcc cgttaacaag aaacgggcgg ataggtgctc ggctgccagc 2173981 tttacagccc ggatcacttc ctcatcctca gcatgagcaa ccgcaatggt cttatttttg 2174041 tgtatcgacg ctttgccgat taaatctttc agcttcatct gttaccacct ttcttgtttc 2174101 gactccgcct tttattatgc aagttccatg ccagctctta agggtgctgt cataccaggt 2174161 ataccgaaac attcgtgcag atgtttgcgt ttattctgca aattattgca tgccttcatt 2174221 tgcaaggcca tatttatcca ttttgtaata taaattccga atgctgacac cgagagcttt 2174281 tgctgttttt gtccggttaa aatgatgctt ttcaagcgtt tgctggatca aatgcgcttc 2174341 aaatttttct actgcgacag acagcttttc gccttcaata tccggaaaat caaaacctgt 2174401 tccctgatct gtgtcatttt ctttttgctc aagttcgaat acaggcaagt gatctttttc 2174461 aatccattcc atatgcggat tcagaaaaat catggctcgt ccaaggacat tttcaagctc 2174521 ccggacattc ccaggccaat ggtaggcaga taaggcgcgc aaggcttgct gtgagagccc 2174581 ttttacattc ctgccgtaat cccggttgat cttttggata agtctgacgc tcaatgcttc 2174641 aatgtcctcc aaccgctgcc gcaaaggcgg gatggagatc ggatagcgat tgatccggta 2174701 atacaggtct tcccggaatg ttccgtccgc catcgccttt tcaatattta catttgtcgc 2174761 cgcgatcact ctgacgttga cagggatcgc tttcgtgccg cccactctga cgatttcctt 2174821 ttcttgaagg acgcgtagca atttggcctg catattttgt gtcagctcac cgatttcatc 2174881 taagaaaata ctgccgttat ttgcttcctc aaataaaccc tttttaccgc cgcgcttcgc 2174941 tcctgaaaac gcaccatcct catagccgaa caattctgat tcgagcaggt tttcagaaag 2175001 ggctgcacaa ttcacgcgaa taaatttatt gtatttccgg tcactttcgt tatggatggc 2175061 atgggcgaac agttcttttc ctgttcctga ttccccgcgc agcaagatgg ttgccggtgt 2175121 tttcgcaccg agcttcgcct gctcaagcgc aaccagcatt tgctcgcttt tgccgataat 2175181 gtcgtcaaac gtgtatttcg cttcaagcgt gcgaataatt tgtctggcgc gattaagctc 2175241 cgctgtcagc attttaattt cggaaacatc gtgaatcacg ccgacgctgc ctttcaaaat 2175301 cccgtccaca atcaccggtg ctacattaac gatcacttct ttttcattcg ggccgacctt 2175361 cattctgaca ccgcggacag gacgtcttgt ttcaagcacc tttaaatgca tgctttcgcc 2175421 ttcggaaata tcagtgtttg caggcttgcc gatgacttct ttttcagaaa gccccgtcat 2175481 tttcgtatac gctttattga ttagcaggcc gatgccgttt tcatcaacga cagaaatcgc 2175541 ctcatcggag gattgaataa ttgcctccag catcgtacgg acctgcttta agttggtcac 2175601 ttcctctgcc agctcgaccg catcagtgat atctttaaac acacaaagag ccccgagcag 2175661 acgtccgcct tcatcaataa tcggcagtct tgtggtcaca atttgcaaat gatcgcctaa 2175721 cagctgcttc tggttgtatt caggcactct tgtttttaaa atccgcggca tcttagtgct 2175781 cggaatcact tcttttattg ggcgcccaat gacttcctca cgtttttttc cgaccatttt 2175841 ttcggccata tggttaaaga gaatgatttc ttcattgata tcaataaaaa tcattccatc 2175901 atgggtggaa ttaaaaattc tgtcatattt ataggtttgc tcttttagca tttgaatcag 2175961 gtgctgcttt tcttccatca gctgaaaaac gatgtatgcc atttttcccg gcatgacaat 2176021 ggtatcttca tgctttcttt gaaggagctc gtcaaacacg gcttgatcgc cggtagtatg 2176081 aatgacgata tccggttttt gttgtatgta aggtttccaa tcagatgata cggcaatccc 2176141 atactgttct gcttctttca atcccggcgc ctcggggtct ttgtcaacta cggcaatgat 2176201 atctatgatg gctgttttaa tcagaatatg taataacgcc gttccccttt tgccggcacc 2176261 tactatcagt accttttgca tcccgatacc cctttgtatg aaaaaatttg cacacctatt 2176321 tattccgttg caataatttg cacaacccta tgttaccacg ttttcttctc ttgacaaaat 2176381 attttttccg ctggacaata aaggaaatga aaagataaag gggttttctg aagatgagcc 2176441 gacttcttgc gcttttaata ttagtcatcc ccggggctat ttctgcttta ggcattaaac 2176501 tgatgagaga tacacttttc ggccatacaa tcaagccatt ttcagctctt tggctccaag 2176561 ggttgtcagg attcatcttt tttgcgatcg gcctctatgt gctggccggg ttcattttat 2176621 acagagacag aaaacgcaat caagtcagcc cgcgattcag aaaacgatag ctgaaaaaaa 2176681 gccggagaat gctccggctt tttttgttgc attattcgtc aggcaaaacg gtcttggcaa 2176741 tcgttttgtc taacgcttca tagtcataat aagaaatcgt atcgtacagt tcttttcgtg 2176801 tctgcatatc atgaagtcct tctttttgtg agccgtgctc cttcatcaaa ccaaacatcc 2176861 gctcacaagc ttttgccgcc gctcgaagcg aggtgacagg atatatcacc atgtgaaacc 2176921 ccatatcttc gaattcatcg gcacgataat atggcgtttt cccaaattca gtcatattcg 2176981 caaggagcgg aacggggata cgctcagcaa actggcggaa ttcattctcc gcctgtagcg 2177041 cttccgggaa aattgcgtcc gctcccgcct caatgtaagc ctctgaacgt tttattgcgg 2177101 catcaagccc ttcctgcgcc ctggcatcag tacgggcaac aacaataagg gagggtgccg 2177161 cttgtttaat ggcttttatt ttttgcgcca tttcctttat cggaactagc tgtttgccat 2177221 ttaaatgtcc gcattttttt gggagctgct ggtcttccat ttgaacggct gctaccctgg 2177281 cttcaagcat ctcccgggct gttcgggcgg catttaagac accgccaaat cccgtatcga 2177341 tatccacaag caaaggcaga tcagctgcac gcacaagatc tttggcccgt tcagctatct 2177401 ctgccgatgt gatgatccct aaatcaggca gccccctgct ggctgtatag gcagcaccgg 2177461 acaaataaat agcagaaaaa ccggcttctt tcgcaagcaa agcggccatc ccgtcatggg 2177521 cgccgggaat ttgaagaatg tccggtgctg acatcagctt gcggaaacgc ccggcaagct 2177581 cctcttgtga cgattgctta ttgacgatcc acgacatgaa acaaaatccc ccttttacat 2177641 gcagaacatg tctacgaatt catttacgcg catcgtttgt aatgtctcat agctggtaca 2177701 gcgctcataa atgtgtttgt gctgtttatc aggaaaatgg gttttgagat tgtcagaaaa 2177761 cttttccagc agtttcggca ctgcttcctc tcttcgaaaa cgatggccga ggggaaactc 2177821 acattccacc atttccgtgc tcgttccatc tttaaaatga acctgaacgg catttgagat 2177881 ggagcgttta tcaggcttca aataatcctc ggtatatgtt ttattttcag tcacttccat 2177941 tttatcacga agtttatcta ttctcggatc attcgctgtt tcagcttcat aatgctgtgc 2178001 ggtgatatca ccaaaaagca aaccgattgc tgtaatgtat tggaggcagt gatcacggtc 2178061 tgccggattg tggagcgggc cttttttatc aatgattcgg atagctgatt catgcgttct 2178121 gatgacaact cggtcaatct cgtcaatccg gttctttacc tgcgggtgaa gaatgacggc 2178181 ggactccgcc gctgtctggg cgtgaaattc cgcaggataa gacactttaa ataacacatt 2178241 ttccatgaca taagcgtcga gcggacgggc aagcttgatc tctttcttat tgaataaaac 2178301 gtcttggaac ccccaacccg gtgcactcaa ggctgtcgga taacccattt ccccttttaa 2178361 cgacatcagc gccaaatgaa cacctctgct cgttgcatct cctgccgccc atgatttacg 2178421 cgagcctgta ttcggtgaat ggcggtatgt cctcaatgct gcattgtcaa tccatgcatt 2178481 cgaaagcgca tttttgattt cttctcttcc gccgcccaaa agctttgctg caacagcagt 2178541 tgtcgcaact ttgacaaaca gcacatggtc aaggccaact cgatttaagc tgttttctaa 2178601 cgccagcaca ccttggatct cgtgtgcttt gatcatcatc tcaagtacgt cgcgtaccgt 2178661 taacggctct tttccttcag acagcctcac tcttgataca taatcagcag cggcaaggat 2178721 tcctcccaag ttatcggatg gatgccccca ctccgccgcc agccacgtat cgttgtaatc 2178781 gagccagcga atcatgcagc caatattaaa cgctgccctc acaggatcga gaacatatga 2178841 cgttcccggc actttgcttc cattcggcac agtcgttcct ggaacaatcg ggccaagcag 2178901 ctttgtgcat tccggatacc gtagcgccaa gattccgcag cccagggtat ccagcaatac 2178961 atgccccgct gttgtatacg cttcggcact agtaatctct ttctcaagca catagtctgt 2179021 gatttcttcg ataacacgat ccgttttcgg cattctacca gctcctttca tgattttgtt 2179081 tgatatcgcg ggcccatgta actgacacgg ggacggaaga gccgattatt ggcatgctgt 2179141 tcgatcacat gggcgcataa accggacgtt ctcgcgctga aaaagatcgg cgtatataaa 2179201 ggaatcggta tgccgagcat ccaatacact ggggcagcat agtaatccaa attcgggtaa 2179261 agcccttttt ccttctccat cagccgctca cccgcttcgc acatctcata taaacgatgg 2179321 tcaccggctt tatcgcataa ttgctgcagc gcctctttca tcatgagtgc tctcgggtcc 2179381 atttttttca tatacacccg gtggccgaag cccatgattt tttcttttct tttcagtttt 2179441 gtttgcaaaa gctgctcaaa atcagatgtc gtttttgcct ccaaaagcaa atacatcaca 2179501 gcttcgtttg ctcctccgtg aagattccct ttcagggaag cgacagcccc agtcaaagcc 2179561 ccataaagat ctgaatgtgt agatgcaatg accctggccg caaaggttga attcggcatc 2179621 tcatgctcac tgtacaggac gagcgaccgg tcaaaaatct gttcttccaa tgaagacggc 2179681 aatttccctg tcatcatgta gagaaaattc gcactgtagg atagggtttg aagcggaaga 2179741 atcggttctt tcttattaat gatcctgtag ctggcagcag tgagggcagg cattttccca 2179801 agaagctgat aggcgcgttc tttgtttgcg gaaggagacc gatcatcaat ttgccgatca 2179861 tagccagcaa gtgccgacag gccggtacgc agaccatcca ttggatgagt gtcctcaggg 2179921 agcagctcaa gcagacggag atgatcagca ggcaggcttg aggcactgtt tattttacgt 2179981 tccagcgttt ccatttcact ttcttctggc agcctgccct ccagcaataa atggacaagc 2180041 tccagatagc tttttgtttc agaaagttct attaaatcat agcctcttat caaaatctgg 2180101 ctggactgcg tgtcaagata agaaatatga gtttctgccg caatcacacc gtccaaccct 2180161 ggagaataat gctgtttctc ctccatatcc tcaacctccg tttttgcgtt ttttgtctat 2180221 caggttccgc caagcaaata cttggaaata atcagtcttt gaatctcgtt cgtcccttca 2180281 taaatttgcg tcacctttgc atcgcgaagc aggcgctcaa ctggataatc cttcatatag 2180341 ccatatcccc cataaatttg aacggcgtct aacgccgcct ttacggctgc atcggaagca 2180401 aattgtttag ccatagacgc ttcttttcca cagtttaggc cgcggttatg aaggtctgca 2180461 gcgtggtaga caagatgtct tgccgcctca gctctagtcg ccatatcagc cagcttaaat 2180521 gatatgcctt gattggctgc aatcggcctt ccaaattgca ctcgctgctt cgcataatca 2180581 acggcatgct caagagccgc ctctgcaatt ccgagggcct gtgccgcaat gccgatccgg 2180641 ccgacattta aattcgccat ggcaatgtga aagccatccc cctctttgcc aagcaaattg 2180701 gcttcaggca cttctgcatt atcaaaaatc agttccgtag tattggagcc ataaagcccc 2180761 agctttcttt ctttttttcc aacggtaaaa ccgggtgtgt ttttttcaac aataaaagcc 2180821 gaaatcccgt gcctgccttg atctggagct gttaaagcaa atgtgatata gatatcagct 2180881 gctccgccat tcgttatgaa tattttcgat ccgtttaata ggtatttgcc gttctttttg 2180941 attgctgttg tgcggaggct cccggcatcc gaccccgagt gaggctccgt tagtgcaaat 2181001 gcgcccaaat ggtctcctga cgcgagattt ggtatatatt tcatcttctg ttcttcgttg 2181061 ccgaaataca gaatcggatt cgtgccgact gaggtatgaa cggagagaat cacgccgaca 2181121 gccgcgctga ttctagaaat ctcatgaatt gccaaaatat aagaaacaac gtccgctcca 2181181 gcaccgccgt attgttccgg caccggtatt cccatcagtc cgtgtttacc catttttttg 2181241 atcagctgaa agggaaattc gtccgttttc tccatgattt ccgcagcggg agcaatttct 2181301 tttcgtgcaa aatcacgcac catttttcgc atcatgactt gctcttgggt tacatgcaac 2181361 tcggccaccc ccggatggaa tagacttcag gaagtcttct cctcatagtc ataaaaaccg 2181421 cgtccgctct ttttgccaag ccagcctgct ttgacatact tgcggagcag cgggcaagga 2181481 cggtatttgg aatcgccaag gcctgagtga aggacttcca taattgataa acacgtatcc 2181541 agtccgataa aatccgctaa tgcaagcgga cccatcggat gattcatgcc cagcttcatc 2181601 acttcatcta ttgcctccgg cttcgccact ccctcataca cgcaatagat ggcttcatta 2181661 atcattggaa gaagcacacg gttggaaaca aacccaggaa aatcattgac ttctaccgct 2181721 gttttcccca tcttttccgc taatgccata acatctaagg ccgtttcttc tgatgtagcc 2181781 aagcctcgaa tcacttctac cagcttcatt acagggacgg gattcataaa atgcatgcca 2181841 ataacccgtt gaggccggtt tgttacagca gcgatttctg taataggcaa ggaagatgta 2181901 ttgctggcca aaatcgtatg aggcgggcaa atgcgatcaa gtgttttaaa catctcagtt 2181961 tttgccgcca tgttttctgc gatagcctca atcacaatgt ccgcatgctc tgcctcctca 2182021 agtgtttgag aaatcgaaat gcggttgatt acgctcttca cttccgtctc ggtccttttt 2182081 cctttctcag catcacgggc cagctgtttc ttcagccgtt tcaatcctgc ctccgcggcc 2182141 tctggattca catcatacat ccgcacataa aagcccgcgt cggcggctgt ttgagcaatt 2182201 ccgctcccca tctgacctgc gccagctacc atgatttgtt tgatttccat tcaaatcccc 2182261 tttttcatca tgttttaatg aacctgcact aagacggcgt ctccctgtgc tgccccgctg 2182321 caaatagcgg caacgcccag accccctccc cgtcgcttta attcataaac aagcgtcatg 2182381 agaattctcg caccgctcgc gccgatcggg tggccgagcg cgatcgcacc gccattcaca 2182441 tttacttttt caagatcgaa acctacgatt ttttcacatg tcaaaacaac tgaagcaaaa 2182501 gcttcattta cttcaaacaa gtcaatatct tggacagtta aaccattctt tttcaggagc 2182561 ttgttaatag caaaccctgg cgctgccgcc agctcgtgcg ctggcattcc cgtagttgaa 2182621 aaaccaagaa ttgtagccag aggccgtttg ccaagctcag cagctttttc ctcagacatc 2182681 agcacgaacg cgccggctcc gtcattgact ccaggagcat tgccggctgt gatagaaccg 2182741 tcacttgcat aaatcggagc aagttttgcg agctgatcca gacttgtgtc acggcgaatc 2182801 gcttcatctt tatcaacaac gtttggtttt ccttttcgac cgatccagtt gacgggaaca 2182861 atttcatcct gaaacttccc ttcatcggcg gccttagctg cccttgcatg acttctcaac 2182921 gcccattcgt cctgctctct tcgtgagatt gcatattcct tggcagctgt atttccgtga 2182981 acagccatgt gcacctcgtc aaatgcgcac gttaatccgt catacaccat taagtcccta 2183041 agctcgccgt cccccatccg tgctccccag cgcccggcgg gaacggcata cggaatattg 2183101 ctcatgcttt ccatcccccc cgcaacaagt atgtccgcat cctgcgcccg aatcatttga 2183161 tcacataaag tgacagcgcg aaggccggaa gcacagactt tattcagtgt ttctgacggc 2183221 acactccaag gcattcccgc cagacgggca gcttgacggg aaggtatctg ccctgagccg 2183281 gcctggacaa ccatgcccat gacgtttcct tctacatcat ctccagagac tccagcctgt 2183341 tgcagcgcct ccttcatcac aatgccccca agctcagcag ctttcacctc tttcaaaact 2183401 ccgccgaatt tgccaaatgg agttcttgca gcacttacaa tgactgtttt cctcatggtt 2183461 tcacctcatt cagaagatag acagcgctta caatttctag ttgtcttcta tgaatgtatg 2183521 ctttgaaacg ggcatgaatg aatgaaaaaa gaaggctgcg tcaaacagcc tccttctaac 2183581 aactattcat ttttcagcaa tgccgaagcc ttttctggaa agtcggtaaa catgccgtct 2183641 gctcccgctt caatgagacg cttcatatct tccggacgat tgactgtata cggccttacc 2183701 ttaatcaaac cgttcctcat tttcttcagt acttcatctg tgacccctgg gctgtttatc 2183761 ttcgggtgat agccggaagc cggaatagac gcgatatatc gatctgcctg ataaagcaca 2183821 tctgaagtta atactgcccg ttcgatatgc ggtgcaagcc gggcgcacag cgccaagctg 2183881 tcatgattaa acgtggatag gatgactctg tcctctacat taaatcgctt cactgcctcc 2183941 agcacttttt cttccattcc ctcatagcgg atcacgctgt tttttaattc aatgttgatg 2184001 agaaaatcct tttttaccgc ccacgagagc acatcttcta gcagcggcac ttttatatcg 2184061 ctgtacgctt gatcgtgacc agcggccgca ttcgcagtct ttacctcatc ataggctgta 2184121 tccttcacga atcctttaag tgatgtcgtg cgattaagtc tttcatcatg aattacaaca 2184181 atgcgtccgt ctttcgtcag ctgtacatca agctctatcc catccgctcc ggcttcaatt 2184241 cctttttcaa atgcaagcat tgtattttcg ggaaattgac ctgatgcccc ccggtgggca 2184301 aaaatctttg tcatcgtttc acctcaaacc ctaaagtttt ctccattata cttattttgt 2184361 cggctccact ctaggattaa ggctgtatca atctactgat cataataaga atcaatgcca 2184421 ttgacaatcg catctgcggc cttttgctgg tattcttcac ttcccagctt gtccgcgtca 2184481 gagctgttcg tgataaaccc aagctccgcc aacacacttg gcatttgtga atatgtaatg 2184541 acgtaaaagt ctgattcttt cacgcccctg tctctcgttt gtaaggaaga aacgagctgt 2184601 gactgaatat cggatgccag acgccggctg ttctcccctt cataatcaga ttgaaaatac 2184661 gtttctgttc ctgaagctga agcaacccct gaattcacat gaatgctgac aaaaaggtca 2184721 gcctgattgg cacttgcctt agccactctt tcctccaagg tcagaaaatg atcgtcagac 2184781 cgggatgcaa caggattggc tccctcctct tttagtttgt ctgtcacatg ctctgagaca 2184841 gccaaattaa tatccttttc aaagagcccg tttccgaccg ctccactgtc ttcaccgccg 2184901 tgtccggcat caatatacac tgttttccct tctatcggct ctgctgcctg tgcacaaggc 2184961 gcgagcgtca aagccaatcc gcacagcgcc aagctcctcc ataacattct caacttactc 2185021 cctccggtca cgagttcttt cgcagctgaa tatcttccag ctgtaaagtt ccattatcct 2185081 tctttgtata tttcaccagg acatgtgtct gatctggcag tgattcacat tcatcacgtt 2185141 tatccttcgg aacttgtatc atggtttctt ctccattaag agaaaccgca atcgtatgag 2185201 gatcagccga gccaatgtat tttccctctt cggtaaacct cggcactgag tcatccgcac 2185261 ttgcaacact gcaccccgaa agaaagagcg cagtaaacag caaaagaacc gtttgtttca 2185321 catgaccacc tcttcctgat gtttggcttt tatctttgac cagaatggag aatttgtaaa 2185381 gacaacgcga atgcaggcga gcaagttcca tgattttcaa aagggctata cgacccgatc 2185441 atttcctgtt gttagaaaga taacgagcag atttgtctat gaggatggct ctaattgagg 2185501 cgccaattag aaaaaattag cggaaagaag caacttttta ttcattttaa aaaatttgag 2185561 aatagggtga gcaaatcgtt tgacgggtgg gtcagccaag cgtaaccttt taaaggatat 2185621 ttactttatt gaaagaagtt aaagccatga aaaaattcgt tctgctgctg gcggcagctg 2185681 tcatcacatg ctccatcggc caccaaatca gtggcggcta caaaggcccc gaaaaagagc 2185741 ggccaaaaca tcactctgca ctcaagatat tcagtcggta aagcagatca attgcattaa 2185801 tttttacata taggctagaa tatgtgcgaa tccaaacgaa agaagatgat caaatgaatc 2185861 ctaagtataa gccacttttt gaaccattta cgtttaaaag cggcgttaca atcaacaacc 2185921 ggatcgcagt agcaccgatg actcattacg cttctaatga agacggtaca atatctgaag 2185981 cggagctcga ctacatcatc ccccgttcaa aagagatggg aatggtgatt acagcctgcg 2186041 caaatgttac accggacgga aaagcattcc ccgggcagcc ggccatccat gacgattcca 2186101 acattccagg tttaaaaaag ttagcacaag ccattcaggc acaaggcgct aaagctgttg 2186161 tacaaattca tcacggcggt attgagtgcc cgtctgagct cgttcctcaa caggatgttg 2186221 tggggccaag tgacgtgttt gataacggca aacaaattgc tcgcgcatta acagaagaag 2186281 aagtggaaaa cattgtgaag gcgtttggag aagcgacaag acgcgccatt gaagccggct 2186341 ttgacggtgt cgaaattcac ggtgcaaacg gctacttaat tcagcagttt tattctccga 2186401 aaaccaacca gcgcacggat cgctggggag gaagcgatga aaaacgatta gccttcccgc 2186461 tcgctattgt cgatgaagtg aaaaaagccg cttcagaaca tgcgaagggt gcattcttag 2186521 tcggctaccg cctgtctccg gaagaacctg agacaccggg attgacaatg actgaaactt 2186581 atacgcttgt tgatgcttta ggggataaag aattggatta tcttcatatc tcactgatgg 2186641 acgtgaactc aaaagcgcgc cgcggtgcag atccgactcg cacacgcatg gacttattga 2186701 atgaacgtgt cggaaacaaa gtgccgctga tcgccgtcgg ttccatccat tccgctgatg 2186761 acgcgcttgc cgtcatcgaa aacggtattc cactggtcgc tatgggacgc gaaattctag 2186821 ttgaccctaa ctggacggta aaagtaaaag aaggccgtga aaagcaaatc gaaacagtga 2186881 tcaaaggcac agataaagaa aaatatcatt tgcctgaacc gctatggcaa gcaattgtga 2186941 acacacaagg ctgggtgcct tataaagatt aatgtgcaaa gactgccgaa acgattcggc 2187001 agtctttttt ccctttatat aaatagtttg tgtacacatc taaacagcaa aagaaagagc 2187061 tccccaccaa cttcgaaaag aaaatccagg aaaaacccct cacgctttct tgcttttttc 2187121 tttttcattc gtacgtctcc tttttacatg aatacgcctt acttacgatt ttgcaggaga 2187181 aaggtttcat tttataacgg acacatctag ggtcgatcat gcttcgtgat cctataagat 2187241 gtatgaatgg accaagagtg caggtaatac cgccatttgc tttccttact tttcaaacct 2187301 atcctttact atatgcggat acttaatatt cttctcccat actacaaatg tccccaaaac 2187361 aaaacgcctc ctatttatca gcgcaaacta ataaataaaa gacgtttgat ttaatgacca 2187421 cttaataagc tcatgtttaa gaagccttat gctctaacct cagcttatcc gcaaccattg 2187481 caatgaattc actgttggta ggtttagctt ttgtcatgct gacagtataa ccaaacaacg 2187541 aggaaatgga atcaatgttt cctctgctcc atgccacttc aattgcatgg cggatcgctc 2187601 tttctacacg gcttgcggtt gtgttaaatt ttttggcgat gtccggatag aggacttttg 2187661 taatgctgcc gagcaattcg atgtcattgt ataccattga gattgcttcg cgcagataga 2187721 gatagccttt aatatgggct gggacgccga tttcatggat aatgcttgtg atgctcgcgt 2187781 cgagattttt cttctttggt tcaggctggc tgctgcgtat aatactgctt tgcgatgatg 2187841 gcgcacgatg cgtcacactg ctggcatttc cgctgacctg gcggatatgg ccgacaaggt 2187901 tttccatatc aaacggtttg agaataaagt aggacgcgcc taaatcgacg gcctttttcg 2187961 tgacatcttc ctgcccaaag gctgtcagca taatgacatt cggctgtttt ttcagatctg 2188021 attccctcag cctctctaaa accgcaagtc cgtctagatg cggcataata atatctaata 2188081 cgagcacatc gggatctttt tctttaaaca gcgacaggca ttcctgtccg ttataagcaa 2188141 cgccgatcac ttccatgtct tcctgtcctt ctatatattc acttaacagg cttaccagct 2188201 ctcgattatc atcagcaaca caaactttaa ttttctccac gtttcttcct ccccaaatgt 2188261 agttaacagg attcaccctt gctacatgtt tacattcgac aaaaccgcta tataccctct 2188321 aaaaaaatca taatcaccaa tattagtggc atatctttgt tattctatgt ttttctctgt 2188381 ttttcgacta aaaatgaaat ttgacaaaca aggaaacgtg aatttgtcga aaaatcttct 2188441 tttgtatatt ttaccgtatg tattctgaga agtgaagagg gatcaaaata aaaaaactgc 2188501 cggaaactcc ggcagtcagc ttgctttttc ttttccataa atatcgattc ctgcttctga 2188561 cagcatccat tcaatatgaa caccgtagcc gcttgtcggg tcatttacaa atacatgggt 2188621 gacagcaccg atcacttttc cattttgaat gatcgggctt ccgctcatcc cctgtacgat 2188681 gcctcctgtt tctttcaaca gtcttggatc ggtaattttc aacaccattc cttttgtcgc 2188741 agggaatttt tgcggcgttg tgctgacgat ttcaatatcg aatttttcta ctttgtcatc 2188801 atcaataacc gttaaaattt cagccggccc ttttttgact tcggtagaaa acgcaaccgg 2188861 caatgcttga tctgatatgt tgttttgaat cggctgatgc agtgtgccga aaatcccaaa 2188921 cgggctgttt ctgttaatat ccccgatcgt tttgcgttct gaggaaaatc gcgccagttt 2188981 ttctcccgga ttaccgcctg tccctttttc aattgatgtt acagtggatt taacgatttc 2189041 tccattctcc actacaattg gtttctttgt gtccatatcg gaaatcacgt ggccaagtgc 2189101 tccgtatttt tttgttttcg gttcataaaa ggtcatagtg ccgatgccag cagcagaatc 2189161 tctgatatat aacccgattc tgtatttgcc ttctccttca tccttttctg ggatcagctt 2189221 cgttttgatt ttctgtttat cacgtttgat cagtaagtct aaagattcac cagttttccc 2189281 agccttttga ataaatgggg ctacatcatt cattttttca attttctgtc cattcatctc 2189341 aataatgatg tcgcccgctt caattcctgc cgtttctccc ggagattttt tgccttcact 2189401 tgtattgatt tgatgaaatc cgacgacaag aacaccgacg gaatgaagtt ttacaccgat 2189461 tgattgtccg ccaggtataa cttttaaatc aggaagaaca tgcacttttg tttttttaat 2189521 tggaaatccg gcaagatcat ataccaattc tgactcacct gattttttgc ccgtcacctt 2189581 gatttcatgc ggatctttct ttactgtaaa cgcttctgag gattctgatg tctgagcgtt 2189641 taccgataaa ctcgtttcaa tcgcttgtgt ttgggtttca aatactctca tttgcgttgg 2189701 aatcagtaaa tattctttta gcggtttgca taaacctaca cttaataacg aaacaaggag 2189761 aattaaacct actgcttttc tgatgttatc gggcattcac tacttcactc tcctcgctcc 2189821 tatcccacac cttctttatg acttgctgct acatcattta attttgcctt ctgacggctt 2189881 atttataact gtcatatgaa gaaaaacatt ggatatactg atgaacgaat ggatgtgcac 2189941 gaaaaaaata agctgcgctt ctcgcgcagc ttacccagtt gttttgactt gatccgcttg 2190001 ttttaaaagt tctttcgcat ggcgtttcgt taagtcggtt acttcgacac ctgcaatcat 2190061 gcgcccgatt tccgctacct tttcctgctt agagagcggc ttgacacgtg tcgtcgttct 2190121 gccgtctttt aactccttcg caatataaag atgcgtatcg gccatggcag ccacctgagg 2190181 caggtgtgta atgcacagca cttgtgatcc tattgacacc ttatggatct tctcagcaat 2190241 tgcctgtgcg accctgccgc ttacaccggt atcaacctcg tcaaaaatga tcgatgtcac 2190301 atcctgttgt gaggaaaaaa tgctttttat ggcaagcatc acccgtgaca gctctccacc 2190361 tgaagcgact ttcgaaaggg atttcagcgg ctcgcctgta ttggttgaaa ttaaaaactt 2190421 caccaggtca atcccttgtt cagtcagctg aacgggctgg ccgtttacaa gcggcgcctc 2190481 ttcattgcgt gacgctgttc tgaccttaaa ttccgtatca aaagttgatt tttccatgta 2190541 caggcttttt aattcccgat gaatctcatc agccagcttt ttcgcccatg tttttcggat 2190601 ttgtgacaca tttgccgctt ccactgcgac atctttgccg acggagtcaa gctccttttt 2190661 caagctttga aggtggctgt ccctgttttc aatttggtca atctcttctt caattttaga 2190721 agcatattcc aaaatgtctt caacagtggc accgtatttt cgtttcagct gtttgatttc 2190781 attaagtcgc gtctcaatat agttcaggcg ttccggatca aattcaagct catccagcat 2190841 atttctcatc tgaaatgtgg catcctcaag caaatagtag gagttcgaaa cactttcaga 2190901 catttttttc agcggttcgt ttatatcaga tatatcttca agctgcgctg atgccattcc 2190961 aacccagtcc aatccgccct gctcactgcg aagcgcgtta tatgcatttt gcagcgactc 2191021 atatatcttc tcaaagtttg aaatttgctg gcgctcttct tggagctgtt catcttcgtt 2191081 aagctcaagc tttgccgatt cgatttcttc gagctgaaat tgaataagat caagacgatg 2191141 ggccatttcc tgttcgcttt cagaaagctg cttaagcttt ttgagcagct tcacataccg 2191201 ctggtaccct tcctgatacg ttttgagcgc gctttccact tcggccccgg caaacttgtc 2191261 caaaagctgg agatgatttt cgtcttccat taacagctgg ttatcgtgct gcccgtgaat 2191321 atctaataaa agcctgccga tctctcttag tgaagcaatc gtgacaagct tgccattgac 2191381 acggcaaacg cttttcccgc tcgtgctgat atcccttctc atgacgatca tttcgtctga 2191441 aacgtcgatt ccctgctcag cgcatacgcc taaaacagga tggccgctct ccaacagaaa 2191501 cagcccttca agttcggctt ttgcttcccc atatctaaca aattcagatg atccgcggcc 2191561 tccgactaaa agagaaatgg catctatgat gatggatttg ccggctccgg tttctcctgt 2191621 taaaaccgta agcccgcgtt caaaagaaac cgtcagttcc tcaataatgg caaagttttt 2191681 aatcgatagt tcagctaaca aacagcatta cacctcttat ctttgttaga ttttctgtta 2191741 cagcagttca aggagcctgt tttttacgcc ttctgtatct tcaggagtcc ggcaaataat 2191801 taaaatcgta tcatctccgc aaatggtccc catcatttca tcccagtcca aattgtccat 2191861 cagcgccccg attgcctggg cattgcccgg catcgttttc agcacaatca tatggcttgc 2191921 tgagtctatt ttcacaaatg cgtccatcaa tgcccgcttt agctttgaca gcggattgaa 2191981 acgctggtcc gccggaagac tgtatttgta agaaccatta tttgtaggca cttttacaag 2192041 gtgaagttct ttaatatccc gtgataccgt ggcctgcgtt actttgtatc catcctgctt 2192101 tagcatgtcg accaattcat cctgcgtttc gatttcattg cttgtaatga tctctctgat 2192161 tttaatatgc ctctggcctt tgttcatgta agcacctcta tttccaagct tatctgttct 2192221 tttatgttat atgattctct gcacattgta catgaatgca gaaaaaagga ataatagcgc 2192281 cctattattc cggtacatct gctttttttt cttttaacgt cttatgtgct tcttctacaa 2192341 cgcgcatgat ctcttcttcc ggcagttcct ggccttcctg tccctctccc ggccaatgca 2192401 aatgaaggag aaactcaata tttccgtctc ctcccgtgat tggagaaaat gacaagcctt 2192461 tacagatata gccttcagcg gcagaaaaac tgatcattcg cttgagcaca tcagcatgca 2192521 ctttaggatc tctaacaatc ccttttttgc cgacggattc ccgtcccgct tcaaactgag 2192581 gcttaactaa agccatgcag tcgctgcccg gtacgagcaa agtccttagg acaggcagga 2192641 tgagccgcag tgaaataaag gacacatcaa ttgtggcaaa ctccggcatg ccctttgtaa 2192701 agtctgccgg tgttgcataa cgaaagttcg tccgttccat cacgacgacc cgttcatcct 2192761 gtctaagctt ccatgcaagc tgattatagc ctacatccac agcgtatgac tgtttagctc 2192821 cattttgcaa agcgcagtcc gtaaaaccgc cggtggagga gccaatatca atcataattt 2192881 tatctttgac agagacggga aattccttca acgctttttc gagctttaag ccgcccctgc 2192941 tcacatacct cagcgggttt cctttgacag ttaacggaag gtcgcggtca attttttctc 2193001 caggcttgtc caagcggttt tcgtttgaat agacgatccc cgccataatg gctcttttgg 2193061 ctttttcacg cgtttccgcc agccctcttt ccactaataa tacatctaat cgttctttct 2193121 ttgacgtcat gatccaattc ctttgtgtgt ctttggtggc atcagtaatc taatacgatt 2193181 tgccacctgc tgttttgtca gtccaatttc ctcaagaagc gctgttacac ttccgtgttc 2193241 aataaaccga tcaggtatac ccattctgtc aatcggagta tgatattcac cttgatcatg 2193301 agcgaattct aaaatcgagc ttccgaaacc gccttctaag accgcttctt caattgttaa 2193361 aattggcaag ccttctttta ggatactctt catcatcttt tcatcaatcg gcttaataaa 2193421 acgcgcattc acaacgcgca cggaaaggcc ttctttctgc agctcttcgg ctgcttcaat 2193481 cgccatttcg attgttgtgc cgaatgttaa gatgacagca tcgttccctg gacgcagcac 2193541 ctcccacgta ccgatcggaa tcgttttcaa ctgttcatcc atttttacgc cgagtccgtt 2193601 tccgcgcgga aaacgcattg ctatcgggcc ttcgtcatag ctaagtgctg tatgaaccat 2193661 gtgctggcct tcattttcgt ctttcggcat cattaagacc atgtttggaa tgtggcgcat 2193721 aaacgcaata tcaaacacgc cttgatgtgt ctctccatca gcgccaacga gtccagcacg 2193781 gtcaattcca ataaacacat tagcgttttg gcggcagatg tcatgaacaa cttggtcata 2193841 tgccctttgc aggaaggttg agtaaatcgc caaaaacggc ttcataccct gcattgccat 2193901 agctgcagcc attgttgcgg catgctgttc tgcgattcct acgtcgaaca tccggtcagg 2193961 gaattccttt gcgaagcctt caagctttga accgacaggc atagccggcg taatggctac 2194021 aatgcgtccg tcctcgcgcg ccattcgctg cacagttccg ctgacaagac cgctccacga 2194081 aggagctgcg gctttcggct ttacaaagtc accggtatta attttatatg gtccggtacc 2194141 atgccatgtc ccaatcgtat cggtctcagc cggtttgtac cccttccctt ttttcgtaat 2194201 gacgtgcaga agaacagggc ctttcgtttt tttggcgtat tgaagattct caatcagctc 2194261 atgataagaa tgtccgtcca ctgggcccaa atacgtaaaa ccgagctcct cgaaaaacat 2194321 tccggagacg agcatgtatt tcaggctgtc tttgacccgt tccgccgtgg cggcaagctt 2194381 gcccccaact gccggaatct ttttaaataa gtattcaagc tcatctttga cccactggta 2194441 tttccccgca gtgcggagcc gtccgagcat agagtgaatg gcaccgacgt ttggcgcaat 2194501 actcatttca ttatcattaa ggatgacaat catgtctttt ttctcgtcgc cgatgtggtt 2194561 aagggcttcg agcgccatac cgccggtcag cgcgccgtca ccaatgatcg gaataatata 2194621 ttcatccgtt cctttaatat cacgggcagc tgccattccc atcgcgcctg acagagaagt 2194681 cgagctgtgc ccggtttccc aaacatcgtg ctcgctttca ctccgctttg gaaatccgca 2194741 aagccctttg tactggcgaa gcgtcgcaaa ttcttttccg cgtcctgtca gcagcttatg 2194801 gacatacgac tgatggccta catcccataa aaatttgtct ttcgggctgt taaattcctt 2194861 atgcagggca acagtaagct ctacgacacc taagtttggg ccgatgtggc cgccggaagc 2194921 ggataaactt gtaattaaaa actgacggat ttcatcactt aatttctcta attcatcaat 2194981 ggacatgttt tttaaaaacg acgggtcctg tattgataaa agatccaaag cggatcaact 2195041 cactttcagc atgaatttct gcaatgatac atgtcttttg catgccgagc tgacaataat 2195101 ctcagacata aaaaaagaca aacgcgcttt tccttttcat ttttcatata aactgcttac 2195161 attttaccat acctcgtgca gccgcttcaa attaggatcg ttttagtgat ctcttgccgc 2195221 aattaaatca caaagctcat ataaaaggtc tttttgaaga gagagtccgc cgatcaatcg 2195281 cttcgcctct tttatatgaa catccaattt atgtttggcc ccttccaatg aaagaagcga 2195341 cgggtatgtc gatttgtcat ttgtggtatc cgagccgaca cgtttgccga ttttctcttc 2195401 actgccttct aaatctaaaa tatcgtctct gatttgaaat ccgattccaa tgtggctgct 2195461 gaaggtacgc agtgtttcaa tgtcttcctc aggcgcatca gccaaaatag caccggcgat 2195521 tacacaaaag ccaaggagct tggcagtttt ccgttcatga atggattcga gctcttcaag 2195581 cgtgacttgt cggttttccg cttccatatc agctacttgc ccaccgacca tgccttcggt 2195641 gcctgccgct gaaatcagtt cattcacaag ccgcaggcgc ttttctgctg acacctcgtc 2195701 tgacacgtgg gaggtaatca gcttaaagct ttctgtgagc agcccgtcac ccgctaatac 2195761 tgccgtcgct tcaccaaaca ctttatggtt tgtcggcttc ccgcggcgca aatcgtcatc 2195821 atccatgcat ggaagatcat catgaattaa cgaatacgtg tgaatcattt cgacagcaca 2195881 gcccaccgga atgccgtctt tttcgctttt tccatatgca tttaaaacag ccagtacaat 2195941 cagaggccgc aaccgctttc cgccggcctg tagagaatat agcatagatt tctttaatga 2196001 gtccggcata tcaagctttt ctgtatagac agaaagctga ttttcaattg tttttttccg 2196061 gtccgccaga aagctcgtta atttatttgt caccttcgtc ttcctcctga acactgaaag 2196121 gtgccagttc gccgtcttct tttaaaatga agtccatttg cttttcgact ttttgcagct 2196181 tttcatggca catttttgac agagccatgc cttcttggaa atagttaatg gcttgctcta 2196241 gaggcacatc tccctcttca agctttgata caatgctctc aagccctttc atcgcttctt 2196301 caaatgtcat gttttcattt tttttcacgt ctgtcatttt tcttcccctc tcttttctaa 2196361 tacttcacag gtcagcacgc catccttcag cttgatttca agccggtcct gctcttctat 2196421 ttgactgaca cttttaatga gtttatcttc tttataagcc aagctgtatc ctctttccat 2196481 cacttgaaga ggacttagtg cattcagctt gccaagaacg gtttgaaatt gggaatgcag 2196541 ctgcttcatt tggatattca tattttttct cagctgattt gtttgttcct ggtatcgtgt 2196601 tctcgcttgt ttcagctgtt catgaggatg caatgcctct aatctgtacg tttcacgctc 2196661 cagctgtctg cttttccgat ctaaaagagc ggtcagctgt gcttgaaact gctggtacgc 2196721 gaggtcaaac tgctgctctt tttgcgcata caaacgcttt ggaaaacgaa aggcatagga 2196781 cgattgcagc gtttgtatcc gttctttttt ctggccgaga tgctgctgca ttgctcttgt 2196841 cattctgact tccgctgttt ttgtccgttc gattaaatca gtggtatgag gcacagcaat 2196901 ctcagctgct cctgtcggcg tcgcagctct gatatcggcg acaaaatcac taatcgtaaa 2196961 atccgtctca tgtccgactg ccgatataat cggaatattg gaagcaaaga tggcgcgtgc 2197021 tacaatttct tcattgaatg cccacagttc ttctatcgaa ccgccgcctc tcccgacaat 2197081 taatacgtcg caaatctctt tttcatttgc ctcttcaatg cgcgtaacga tggatctgct 2197141 cgcattttca ccttgtacga gcgctggaag aacaatgact tttacaaggg gatatcttct 2197201 ttttagagtt gtaataacgt ctctgacagc ggcacccgtt ggagatgtca caaccccgat 2197261 tgtggctgga aatgcgggga tttgtttttt gtagcggtcg tcaaataaac cttctccggc 2197321 aagcttcttt tttaattctt cgtacgctaa ataaagcgct ccaaccccgt caggctgcat 2197381 ttctttggca tataattgat agtttccgct cggttcatat acggaaattc cgcctctgac 2197441 cagcactttc attccgtttt caggtttaaa aggcagacgc tcgctttgtc tcgcgaacat 2197501 caccgactgc attcttgcgt tttcgtcttt taaagtgaaa taaatatgcc ctcgtgtgtg 2197561 tatctttaca ttcgacaatt cgcctttaat ccaaatattt tcaaggtgag gatctacatc 2197621 gaattttcgt tttatatact ttgtcagcgc tgagacggtc acatacgctg cttcacccat 2197681 gtctaaaaac tcctctccta agcattcctg caccataact aaagaaaacc cgccctggct 2197741 ttaggagcct gaagaagcgg gtatcgtgct catattcaag gcgggtaaac atttcgcctg 2197801 tgaatatctc caattatcta tgataacgta cgtttcgcag atttaacagt attatgcgca 2197861 agcatcgtga tggtcatcgg acctactccg cccggaaccg gcgttatgaa ggacgctttt 2197921 tcctttgccc cttcaaattc aacgtctccg caaagctttc cgttttccag acggttaacg 2197981 ccgacgtcaa tgacaacagc gccctctttg atctggtctg cactgatgaa gttggctctg 2198041 ccgactgcca ccaccaggat gtccgctttt ttcgtatgtt cagtaatatt ttctgttctt 2198101 gaatgacagt aagtaaccgt cgcgttttca tttaataaaa gctggccgac aggtttgccg 2198161 acaatgttgc ttcggccgac tacaacaacc tctttaccgg aaaggtcaat attggttttc 2198221 ttcaaaagct caacaattcc atgaggcgtg caaggaagaa acgtatcttc gccaagcagc 2198281 attttcccta cgtttaacgg atgaaaaccg tctacatctt tatcagggga gatacgttcg 2198341 atcaccgctt tttcagaaat atggtctggg agcggaagct gaacgagaat gccatgaaac 2198401 tcagggtctt ggttatattg atcaataatg gaaagcagtt cagcttctgt gaggctgctg 2198461 tcaaattgat cgagcttgaa attcattccc attgtttctg ccgctttttt ctttcctcgc 2198521 acgtaagagt gagaagcagg atcatctcca atcaaaataa ccgccagtcc gggagtgacg 2198581 ccttgctttt taagctcttc tacctctttt gccaattgtt cgcgtttttc tctagccgtt 2198641 tcttttccgt cgatgattgt tgcagtcatt ttctttcctc ctatgattgt tcaatatcag 2198701 atttaatgtt agaaagaacc ccgtttacaa actttgtcgc tttgtcatca ccaaaccgtt 2198761 ttgccagctc aatcgcttcg ttcatggaga cattcaccgg aatgtcttcg gcatatgcca 2198821 tttcatatgc tgccaggcgc aaaatcgcac ggtcaacatt ggcaatccga tcgagcttcc 2198881 aattcaccag atgcttggag atcatttcat ccagctggtc ttggtgttcc aataccccgt 2198941 gtacaagctg ttcaaagaaa ggatctgttt tttcttcatc cagtgcgtgt tctatggctt 2199001 cattcactgc aatatcgctg acatcaattt gaaatagtgc ctgcaaagct ttttctcttg 2199061 ctgttcttct tttcattttc tttctccttt gatcctcttt atccgcttgt cgttaagcca 2199121 caaagagatc ataacatatt tttttcgtat ccgcatattg aaatcaaggt ttttttaccc 2199181 tattaccgaa tattttcaca caccttaata tgattattcg gatttcacgt tcatgaagaa 2199241 actcggctat gtaagccggc tttcttcatg ctttgaaata aagggtaacg tgtaaaaaaa 2199301 ccaaagggcc gccctcccct tggtttcgtg ttaagccatt tacatttctt cgtcgatttg 2199361 gacttcttgg gcttttgtgt caaattgaat gccgacgatg tgaatattga tctcgttaat 2199421 cgaaagagac gtcatattta ataaggtttg acgaatgttt tcctgaacgg atgctgcaac 2199481 tttcggaatc gaaacgccaa atgtaacgac acagtataca tcgatcgtaa ttccgtcatc 2199541 cgccaggtcg actttgacac ctttgccatg attcactttg ccaaagcgct caacgacgcc 2199601 tgtcgcaaag tttccgcgca tttcggcaac tccatcaact tctgatgctg caatgccggc 2199661 aatgacctca atgacctccg gtgcaatctc aaccttaccc aaatgcgtat cttcgtgatc 2199721 cattttaagc aagctgttgt ctttcattca attcacctcc gtaaaaatta tgagcccatt 2199781 acatcatatg tttctaaaaa tttcgtatta aactctccgc tcacaaatgt ttcgtgttca 2199841 agcagtttta aatggaaagg gattgttgtc tcaatgcctt cgatgacgaa ttcgctcaat 2199901 gcgcgcttca tgcgggcaat cgcttcatct ctcgtttttc cgtatgtgat tacctttgca 2199961 atcatgctgt catagtacgg tgggatggaa tagccagggt acgcagctga atcgacacgg 2200021 acaccaagac cgccaggagg caggtacatt ttaatttcac caggtgacgg catgaaattt 2200081 ttgcttgggt tttctgcgtt gattcggcat tcgatggccc agccttcaaa ttcaacatct 2200141 tcttgcttga ggctcagttc cattcctgaa gccactttga tttgttcctt gatcaggtca 2200201 gttcccgtca ccatttctgt gactgggtgc tccacctgga ttctcgtgtt catttccatg 2200261 aagtaatagc gctgttcatt gtagtcatag ataaattcaa ctgttccagc acctgtatag 2200321 ccaaccgctt tggcagcctt taccgctgca tctcccattt gctccctgat ttctgaatca 2200381 agggcaggag atggtgattc ttccaaaagc ttttgcaggc gtctttggat cgagcagtcg 2200441 cgttcgccca aatggatcgt atttccgtag ttatcagcaa gcacttggat ctcaacgtgg 2200501 cgaaaatctt ctatgtattt ttcgatgtat acacctggat tcccaaatgc agttgccgct 2200561 tcctgctgtg taatcttaat gccattaatc agttcctctt cagtgcgggc aaccctaatt 2200621 ccttttccgc ctccgcctgc ggtggctttt ataattacag gatacccaat ttcattagca 2200681 agcgaaaccg cttcttccac attttctata attccctgtg aacccggtac gattggcacg 2200741 ccggcctgtt tcatcgtttc ccgcgcaacg tcttttgttc ccatttttga aatggcgtca 2200801 gcgctcgggc cgacaaacgt gacattcact tcttcacata attcagcgaa atcagcattt 2200861 tcagctaaaa atccgtatcc cggatgaatg gcgtccgtgc cagtcagctt tgcaacactc 2200921 acaatatttg taacgtttaa atagctgtct tttgatgctt tcggtccgat acaaaaagct 2200981 tcatcggcca tttgaacatg aagggcatct ttatcagctt ctgaataaac agcgacagtc 2201041 tcaattccga gctctctgca ggctctgatg attctgacag caatttctcc tctgttggcg 2201101 atcaatagct ttttaatcat gttcagtctc cttactccgc ttttacaaga aatagaggtt 2201161 gtccgtattc gaccagctgg ccgttttcta ctaatacttc aacgatttcg cctttcactt 2201221 ctgcttcgat ttcgttgaaa agcttcatcg cttctacaat gcagacaact gtgttttcat 2201281 ttacttttga accggctgtt acatacgggc cagcttccgg tgatgaagaa gcataaaatg 2201341 ttcctaccat tggtgaagtg attttatgca gattctcatc ttgctttggt gcttcttggg 2201401 caggtgccgc tgcttgctgc gcttgcggct gaactgcctg cggagcctgt gcttgtacag 2201461 gtgctgccgg tgcctgctgc atgacttgaa ccgtgcctgc ttcgtgtttt ttcagtttta 2201521 aggatacacc ttcattttca tatacgaatt cgtcaattgt agactcgtca attgctttaa 2201581 tcagctcgtg gatttctttg atatttaaca ttcaatcgca ctcctatgta tgaaatttct 2201641 ttttttatag gttactacta aaagtacata ctatgttcat cttacaggag cggacttttg 2201701 aattcaactc taatatgaca gcaacgcaaa aagcccgctt gtttagcggg cttttttccc 2201761 tcattcttat ttagagggtt caaatgtgac agcgacatct ttcattgttt tgatttcttt 2201821 tgccacaagg tctataatgg ctgtcgcctt cgatttagag tgtttgtctg atttgactgt 2201881 aatattgatt ttatctcctt cagcattaac aagcgcatcc tcgtaacctt gtgttttaat 2201941 cagcgtttcc agctgttttt ctgttccttc cacttcactg agagccgtca ttttatcgta 2202001 tgcttcgctt ttctccttgg ctgttgcatc atcgcttgac acaatggcat tcagctcttc 2202061 tctttctttg cttctggcat cttctaaatc aagacggtac gttgtaaaca aatcatcatc 2202121 ggctgtttcc gtaacaacag ttcctttttc actggcttca gcggatgttt ccttgtctgc 2202181 tgatgaatct ttcgttccct ttgttccatc ttcttttcct ttttcagttt ctgtaccgct 2202241 tttttccttc gtgtcttgct tggcaggcgc tttttcagtt gcgacctctc cgctgtcaga 2202301 cgcgcttttt tcactttgca tctgcacggc gtttttgctt tccggcgaca tgatatagta 2202361 gacgcttaac accacgacaa gactgagcat tgttaatagc caaacggttt gttttttaag 2202421 catttatgaa tcctccttta tttttttagg ggcaaccgca acccggtggc ttggaacatc 2202481 caggacccgt gtcaccgctt cgataatggt ttgttttatt tgaacgttgt ccactccttg 2202541 agcaacaacg agtacaccgc gtatatcagg ttttttcgtt tggacgacga caggtgtttc 2202601 tttatcgccg tttttgatca tgacgatttc ttcctccgat gattggtctg taacgcttct 2202661 ttttccgcct tctttgtcag tttcttcagt ggttgtattt ttgtttgatt tgtttttttc 2202721 gtatactttc agcgacgttg catctacatt cacgacaacc gagacatcgt ccacaccaat 2202781 gattgtttca agaatttctt tcagttgatt ttcgtattct ttttcatagt catcgatcga 2202841 gtctttaggt ttatcagatt ttgaggcttt aaacacttcg gctgttttct ctttgctgtc 2202901 tgcggaatgt tgtgatgata cggccgttat cgttttggcg ttttcagttt tctcaggtga 2202961 agaaaacagc tggctgacaa gcataaagga aactccgaga acaaaaacga atagaaagta 2203021 atgatatttg gtcagcttcg gcttttcgcc gtccttcgtt tgtcccggaa gaaactgctt 2203081 tttcaataca ttccataatc cgtttttatt cattgccgac actctccccg ccttccatat 2203141 gaaccgtaat tttctcactt ccgatttccc aaatgtccgc gagctgcgtt tgtatctgtt 2203201 tggcttcttt ttgttcggct gcttcttttg ttacgtatgc atgatctgta tcaatgtgga 2203261 ccggcgcgac cgtttggacc gttttttcag aagacggggc catatacacg ctgattgttt 2203321 taatatcctc ttctgaatct accttttctc ctgccgtgag tttgatgcgg cctactttat 2203381 attcatcatg actgaatctc tcctccgctt tcttttttag ttggacagcc atttcttcta 2203441 gaatatatgc gcgctgggaa gcttgtattt ctattttttt tgaattgatt tgatttttta 2203501 tgtcggcaga ctctgactgc ccgttttttg tgaggtattc aaagatgact tcggggtctg 2203561 tcttgaaaag tttaaaaatc ggcgtaagca tgacgacaat caagagcagg ctgactacca 2203621 tttttgcgta cttttgcatg ctggagctcg gcagcagcat atcaatcaca attgcaaata 2203681 ggataaacaa cacgatggtg gtaagccatt ccgttaaaaa actcatttgc ctgcctcctt 2203741 catttcatca tcatcgtgag gtttccggct gtgattatga cagtaaggct taaaaaaaac 2203801 atgagagaca caatggcgag agctgcaaaa atataaatga cgcttttgct gatgacgtcg 2203861 aggcaggtga tgacgggccc gcctcctagc ggctgaagaa tcgcggctgc cagcttataa 2203921 ataaaagcga gggaaagcac tttgattgcc ggaaatgccg caatacagat caaaatagcg 2203981 acaccgagaa tccctaccgt atttttcagc agtaaagagg cgctgattac tgtatctgtt 2204041 gcgtctgtaa acattcggcc aagcacagga ataaaatttc cggttataaa tttagccgtc 2204101 ctgagcgtaa tgccgtctgt cactgcagct gacgctccct gaacagagat gacgccgaga 2204161 aagatggtaa gaaaaacagc cagtgctccg atggcgatat ttctgagcag gttagccagc 2204221 tgcgttactt tgtattgttc agtcatcgtg ctgacaatgc tcagaatcgc tgataaaaaa 2204281 atcagcggca tgacgatatt ctgaatcaag agaccgctcg tgttcatcag gaagaggata 2204341 acaggatgaa agaaggcagc agatacagct ccgcctgagg aagccaaaag cgccaagagg 2204401 agcggaatga gcgccaggat aaagctggtc atcgtctgaa tcgcctcagt tgcatagtta 2204461 attgccacat gaaagctatt aagcgcaagg ataatcagca ccatgtacac aattgagtaa 2204521 gcgaccttac tgacggtgct ttgctgaaaa gcattttgca aaagctgcag aatgacgcaa 2204581 aaaatcgtga gcaaaatcaa tgtgcccagc agctttccgt tggcaagcac ttcatgaaac 2204641 aaataagaaa agagagcttt cagccattct tgcggtgaga atgatttatc gccattgata 2204701 aactccatta agctgccttt ttggctttcc ggcagcagtc cgccgtattc tgtcataatg 2204761 tcattccaaa attccccgat cttatctgtt tcaagcgagg ctgctgtcct ttccgctaat 2204821 tgctcggctg tttcagcatg gtcttccgtt tgttctgcat taccagctgc ttgtacaatt 2204881 tctgcacggc ctgctatgat cagcacggcc aaaagcaaaa cccattgaaa gcgcttcaat 2204941 ctaccgcctc ctttcggtta tgacatagaa ggtataagtc cgagaatcgt ttcgataatg 2205001 acggttaaaa taggcacagc cattacgagt attaaaattt tccccgccaa ttctattttc 2205061 gaggcgatgg ctccttgacc ggcatctttt gtgagctgtg ccccgaattc agcaatatag 2205121 gcgattccga taatctttaa aatggtttca acatagacca tgttgacatt tgcattaatc 2205181 gcaatttttt ctatcattcg aataatgtcg tagatttggt ctaccaaata aagaaaaatg 2205241 gcacatccgg caaaaacgac gattaaaaac gcaaaagtcg gcttttgttc ttttacaatt 2205301 aaagaaagga aggtggcgat cagccctaaa cctacaattt gaacaatgtc aatctgcaag 2205361 cccccctatc cttggaataa aaacacagct tttatctttt taaataggtc atctacaatc 2205421 gtggcgacca taaataaaat atagataaaa cctaacagcg tcacccactg agcatattct 2205481 ttcttgccca tctgatccaa tatcgtgtgt aaaaaagcga ccacgattcc cactccggcg 2205541 atttgaaata tgacattcac gtctactccc attttatttt tgctcccctc acgtttacat 2205601 caatagaaga atgagtaaca agcccgctaa aaagcccaaa ctttttatca tcttttcgtt 2205661 tttcgcttgc gcctgctcag catccgcttc tgaggcttcc aaatgtgtca gcgccagctt 2205721 gatgtgcttt tgctgagaga ttcgatcatg aatcccaagc gtctcgccaa actgcttcag 2205781 cacttcgtat tcgctttttt tcaaagacag ggtgtcccat accttcttta agctttgctc 2205841 ccacgccgtt ttcgcggaat cacttccctt gtccagctga tcactgaatg cggaaaaaag 2205901 agttgaaaca ggctgtgcga gctgtttggc aatctgctgt gaagcagtat gaagcggtgt 2205961 atggccgtac atgatttcag cctcgaggga ttgaagcgcc gcacgcagct ggcggatttg 2206021 ccgcggccgt tctgtataaa tcttcgccat ctcaaaacct gtccatgttg tcgctaccac 2206081 aatgaataca gcgcccagca gcttcagcat gttttcacgc ccgtcgtcct agacagcaca 2206141 tttccgtctt tgtcataaat ttggctcact gtgcccggcc cttttgctct tgataattcc 2206201 aaatagcggt caaaggctct ttcttcccac aaacgcttca atgaaggccg cttcatcagg 2206261 tcggatatac tccagccatg cgccgatacg attactgaaa caccggcatg cagcgcctcc 2206321 agaagtgcat ctgtatcttc catacgcccg atttcatcga caatcatcac ctcagggctc 2206381 atggatcgaa tcatcatcat cagcccttca gcttttggac aggcgtctaa cacgtcaatt 2206441 ctctgaccaa attgatgctg cggaataccg cgaagacatc cggcaatctc tgaccgttca 2206501 tcgacgatcc ctgtctttac gggcagcatg ttttttttgc cggtgcttga gagcctcgca 2206561 aggtcccgga gaagtgttgt tttgccggtt tggggcggtc cgataatcag cgtattcagc 2206621 cagctgtttt gatataagta tggaagcagc ggctccgcaa tccccagctt ttgccgggca 2206681 attcgtatat taaaagatgc gatgtcacgg aggcctttca cacctccgtt ttccgtaatg 2206741 actctgcccg ccagtccgac tctgtggccg cctctgatcg tgacataccc tttcttcagc 2206801 tcttcttcaa gtgtatacat actatagttg ctgagccggc tcaggatcag atgggcatcc 2206861 tcggccgtgc ccgcatagga caaataaaca ggttgtcctc ttcgaatcaa ttcaacaggg 2206921 cggttgatcc gaattctgac ttcttcgatt tccagccatt gttgttccgg tatttcagaa 2206981 agggcgtttt tcatggattc agggagaacc tcagcgattt cattcaacag agcctcctcc 2207041 tttctaccga ttggcttctt taaaatgtat gatgtgaggc agactttatg acaagcctct 2207101 ctttatttat gaacacccgc caaaatcaag acaacacccg taaaaatcag aatcagcttt 2207161 gcatacgaaa gctgcccggc aatttggtag attccgacag tcattgtaat gataaaaatc 2207221 aacggaccga caatagcgag aatgctgtta accacaaccg ccttccggac atcgttggtc 2207281 acaagcatga caattgctgc cgtcagctca atcatagagg ataaaactcg taatcccgcc 2207341 attgttaaaa cagtagaatt gatatttcca agtaaaaatt tcatagcact ctcccaacct 2207401 cccatttttt tatatgatat gctctagctt gctgaagtag tcttgtcatt ttcgtataaa 2207461 agaaagattc tgtttttggg cacaaaaaaa gcctgctccc atttgggaac agacttcttt 2207521 ttttctttct atgctcttga aacgtaagaa ccgtctgatg tattgacaac aagtgtgtcg 2207581 ccttcattca caaagaacgg cacgtttaca acaagcccgg tttcagtttt cgcaggtttt 2207641 gtaccgcctg acgctgtatc acctttaata ccaggttcag tttcaacaac tttcagctca 2207701 actgtgtttg gaagttcgat accaagtgtt tcatcctggt acatcatgat atgcacagac 2207761 atgttttcta gcaggtattt taattcttct tcgatttgag ttgcgctcag ttcaagctgc 2207821 tcataagaag aagtatccat aaatacgtgc tgatctccgt ttgcatatag atattgcatt 2207881 gttttggttt cgatttgcgc tttcgctact ttttcaccag cgcggaatgt tttttcctga 2207941 atcgcgccag tgcgaaggtt gcggagttta gagcggacaa atgccgcacc ttttccaggt 2208001 tttacgtgct ggaagtcaac gacgcgccaa atgccgccat ctacttcaat tgttaatcct 2208061 gtacggaaat cgttaactga aatcatgttt aatgtcctcc tatattccaa tcacaaaata 2208121 ataagttctt ttggggaatg ggtgattgtc cggttgccgt tttctgtaat cacgatgtca 2208181 tcttcaatgc ggacaccgcc tgtttctggt atgtaaatgc ccggctccac tgtgaccacc 2208241 atacccggtt caaggatagc tgaagatctg acggataatc ccggcgattc atgaacttcc 2208301 atgccgagcc cgtgcccggt tgaatggccg aaatagtcac cgtagccttt tgcagcaata 2208361 tgatcccttg tgagggcgtc agcctctttt cctgtcattc ccggcttaat atgtgcgacg 2208421 ccaagcgcct gagcatcaaa tacaacctga tagatctcct tcaattgatc actgggctga 2208481 cctacagcga ccgtccgggt aatatcagaa caatatcctt tataataagc gccaaaatca 2208541 agcgtaacaa ggtctccgct ttcaatcagt ttgtcactgg ccacaccgtg cggaaggctt 2208601 gaacgaaggc ctgaggcgac aatcatatca aaagaagagc tgtctgctcc ctggcttctc 2208661 atataaaact ccagctcatt ggcaacagcg atttcagaaa tgccgggttt cataaacgtc 2208721 aagatatgtc tgaaggcatc atctgcaatc ttcgcagctt cctctaatat cttaatctct 2208781 tcactagact taatcaagcg caacttttcc acggattcag ccacaggcac taattcggca 2208841 tcactgataa cggcgctgta tgaagcgtaa gtgccatatg tcatgctgtt ctgttcaaag 2208901 ccgagacgct tgatgccaaa cgattcaaca gtgtcggcag tggtctgaat caagctgccg 2208961 ccatgttcaa tgatctcaaa accctttacc tgaaccttcg cctgctcagt ataacgaaaa 2209021 tccgtaataa acgctgcttt gtcacccgat ataacagcca aacccgccga acctgtaaac 2209081 cctgtcatat agcgtacatt agtgttgctt gtaatcagca tgccgtcaat tcccagctgt 2209141 ccaaacaggt ttcttaattt ctctagcttc atcttgattc tcccccttgc tggcttaata 2209201 agtagcgaac agcaagcttg tagccttcag ctccaagacc gacaatctgc cctttcgcaa 2209261 caggagcgat aaccgactga tgcctgaatt cttccctggc gtataagttt gataaatgca 2209321 cctctaccac aggaagactg atgcttgaaa cagcatccct gatcgcatag ctgtaatgac 2209381 tcagggcgcc ggggttcaga acaatcccgc tgtattgctc ctcagcctca tgtatcgcat 2209441 ctatcaaatc accttcgtga ttagactgga agaaagtgag ctggatatgt aaggcttcag 2209501 caaactgaaa aagatctgtt tcaatatcgg tcagtgtctg gcggccgaat acttcaggct 2209561 cacgactccc aagccggtta acattcggtc cgttcaaaat caaaaaatga ggcacacaat 2209621 ctctcctttt cgcgagggtt tctcatgtaa aaaatgttca cttctcgtga acattttatc 2209681 atactggaaa aggattatac actattctct atgcattccc agcgcacgtg caagcttttc 2209741 cgaattcagc tcattgtatt caaatgaaat agaatacccg acaaacagcc cgtaaagcaa 2209801 ataaatgcaa atggtcgtaa taattgtatc tgatgtcagt tcggtcaccg tgcgcacatc 2209861 tggaaaaatc ggattaaaaa caaaaaacac gagcagccaa agcaccaagc cgtataaaat 2209921 acccggccac attgttttta aacgtttcaa tagaagaaaa taaagaaatg ctgcgccaat 2209981 tgaaattact ccaatcaaaa tgatgctgat taccgttccc agcccatgtt ttttccactc 2210041 tccgagtaca aacggctgca atatcatatt cgggctgatt tcggaaaaat gaaacaaata 2210101 tgcgatataa gcaacgaaac tccaaagtac gcctccgcaa aaacctgttg ccgccaccct 2210161 gccggccatt gaaacaggcg gcttttgctt ctcattcaat tcttcatttt gttctgtatc 2210221 tttttcgctt gtcatcatgg cacctccagt taaagtgtgc ccaaaaaatg aaatgtcaat 2210281 aaaaaagctc acactttttg gcagctgcga gtaaaatttg aaaataacgg gtataatgca 2210341 tgtagaaaaa gcaaggctat ggcaattttt tcagcctgtc aatctagagg tttagcgctg 2210401 tttcctgtac aatagagtga aaggaaatgg ttagcaatcc taaagaaata ggcaggttga 2210461 taatatgtca aaacataaag ttccgcccgc ttacggcggg caggctgttg tggaaggcgt 2210521 tatgtttggc ggaaagcatc attacgttac agccatcaga agaacggatg gaagcattga 2210581 cttttttaag cttccacgca aacacaaccc gaaactgaac atcgtgaaaa agataccgtt 2210641 tttacggggg atcgcggcca ttatcgaagc gagtgcaaac ggcacaaagc atttgaattt 2210701 ttcaagcgaa cgttacgggc tcgatccatc tgaagacgag acacttgagc aggaagaaaa 2210761 aaaatcctct gggctgtcta tgtatctcag cctcgcagtt ataggcgtcc tatcattttt 2210821 gttcagtaaa ttcgtattta cattggttcc agttttctta gcggaactga caaggccgat 2210881 tttttccttg aacacagcgc aaatcgcgat tgaaagcctg tttaagttga ttttgctgct 2210941 cggttacatc tattttttgt ccatgacacc gcttattaaa agagtgtttc aatatcatgg 2211001 agccgaacat aaagtcataa actgttatga acagaatttg ccaattactg tggagaatgt 2211061 ccaaaaccaa tctcggcttc attaccgctg cggatcaagc tttattttat ttacgattat 2211121 tgtcggcatg tttgtttatt tactcgttcc gacagatccg ctttggctgc gtgttataga 2211181 tcgtgtcgca ctgataccgg tcgtgcttgg tatatccttt gaagttctgc agctgacaaa 2211241 caaagtgcgt gacattcccg gtctgaaatt acttgggtac ccgggacttt ggcttcagct 2211301 gttaaccaca aaggaaccta aggatgaaca ggttgaagtt gccatcgaaa gctttaacga 2211361 acttctcaga ctcgaagcat tgtctgagca aaatcagaag ccttctcaca acgtcatcta 2211421 aaatccgttg ccctgctatt actttcggag gtggacagtt atgaatcatc gtgtacaacc 2211481 tattattgct gtattaattg cgctgggagc gttcggtttc ctctatgtgc tggtaaccaa 2211541 tcccggagaa atggcaaaaa tggcggtaac cgtcatcgtg gcaggtatca ttatttattt 2211601 tattgtgaaa tatgtaatga atcgaaatgc gggcagcgaa ggagcagcct tcaaaaaagc 2211661 ggcgaaacaa tcacggcgcc ggatgaaaga acaaaaagca aaacaccgcg ccggacataa 2211721 gggacgtgtc agccacctgc gaagcgttcc gagcgccagc aagcctaagc cgatgattct 2211781 caagaaaaaa agccagactc agctgactgt tatagaaggg aaaaaaaata aaaagaaaaa 2211841 cagagcgctt ttttaatagg tccactgctt taaaaacagc tctgtccgtc ttttacctag 2211901 ctcaatcagg gctagttttt tttgttgtgt taaatgaaaa tcagtggcca ttacgtcatc 2211961 aacagggaga aaaatgatat tttgttcata gcgtgacgca atgtgccttg cgtcatgagc 2212021 atccttcatc gtttcaaaca gggcgccgaa cagttcaaaa gcgttgcgga tatttttttt 2212081 cggacgctct ctttcacgcg gcgcaagcgt gacaccgatc acagggcgct ttctttcctt 2212141 tgaaaacagc cagattggaa aattgcttaa cacgcctccg tcgacaaccg tggcggtgcc 2212201 tgtgtccgtt tttaatttta tcggttcaaa gaaatacgga atgctgcagc tcattctgac 2212261 cgctctggca accgggaaca tatctggatt taacccgtaa cgggccaaat cgtccggcaa 2212321 aacaatcatg gtgccgtttg tcagatcaga agcaataagg cgcagagacc ctttctgcaa 2212381 atcgccgaaa acccttatgc ctttcgctct taacagatca gcaatccatt tttctatcgt 2212441 atcgcctttg tataagccaa gacgccagta gatggacacc cactggagca tctttaaggg 2212501 gagaaatgag tacctctgat ccagcaattt ctctccgtcc acttcttcaa ttaaagcgtg 2212561 gatttcctta ctggtgtaac ctgacgcaat gaaagcggca ataatggcgc cggcgcttgt 2212621 acccgcaact cttttaaagc ggaagccttt ttcctcaagc acttcataag cgcctgcgag 2212681 cgcaatgcct tttactcctc cgccggaaaa cacaccgtca atatacatct cattccctcc 2212741 ccctccatcc gatcgtttat taccatttta agaaaacacg cgaagaaata gaccaacgaa 2212801 tgacgggtgg cgtcagcgta tcaaaaaaga cggcctcctt cgagaccgcc tttttactga 2212861 ttatgatgtt ctgttttctt ttggattgat ttcagatctt ttttacgggc atcatcttct 2212921 tcaaaatatt gaacaagatc cccgatgcga tcaatactgt tccagcttaa atgatgttcg 2212981 attccttcga catcgttata tattttctct tcatcaacac caatgattct taaaaactgc 2213041 tcaagcaatt catgtctgta taccagccgt ttgcctattt ttttcccttt agacgttaac 2213101 acgagaccgc gatatttttc ataaattaaa tattcgtctt tatctagttt ttgaaccatt 2213161 tttgttacag aggagggatg gactgccaat gcttccgcga tatcggaaac tcgtgcatat 2213221 cctttttctt caatcagcat ataaatctgt tcaatataat cttccatact tggtgttgtc 2213281 atcgaaaccc tcccaaaaag caccttaact ttataaacca ttacaagttt acactaatga 2213341 acttgaaaaa acaaggatgc tccgcgggtc aaaagccctg tttaccgctt ataattccat 2213401 tcatctgaag cgtactttgt ttcagccaag tgatgaacaa aatcaagctc ttcctgagaa 2213461 agttcatatg gctccaaatg aatgttaaga cctgtttcaa atccttcttt aaaggcttta 2213521 cgagcctcat ccatcgtcac ccgcttttcg atgagttcat taatggcaac cgctttattt 2213581 ttgaaattgc gctgcatccg ctctcttact ctttcacttg gatataagaa cagatcgaac 2213641 agcttgtcct catctaaatc aagaagaatg gagccatgct gaagaatcac acctttttgt 2213701 ctcgtttgcg cgcttcccgc caccttgcgc ccctcaacca ctagttcata ccacgaaggc 2213761 gcgtcaaaac aaacagatga ccgcggattt tttaagcttt ctttttcttt ttcagttctc 2213821 gggatggcaa agtaagcgtc cagaccgaga tttctaaagc cttgaagtat gccttctgaa 2213881 ataacccggt aagcctcagt aacagtcgcc ggcatctcgg ggtgctcttc cgaaacaatt 2213941 acgctgtatg tcagttcctg atcgtgcagc acacctctcc cgccggtcgg gcgtctgacg 2214001 aatccgagat tatatttatg tactgcttca aaattgattt cctttttaat attttgaaaa 2214061 taccctacag aaagtgtcgc cggattccag ccgtaaaaac ggataaccgg ggggattttc 2214121 ttttcgctgt gccaatataa aagcgcttca tcaagcgcca tattgaatgc aggacttgca 2214181 ttgcctgagt ctataaaccg ccaagtttct ttttgcattt taagaccttc cttaccgttt 2214241 taatagaatc agtttatcaa actgtcggga aaatgaaaaa tattttagtt ccattataga 2214301 tgacaatcac gctgtgcttt actataatag tatttgtcga aaacggctct atgaccttgt 2214361 tttatgaagc agggttttga ttttatatgc taaaggagta gaatcacatt gtctaatatg 2214421 atcgttttga ttatttttgc tgcatttatc atctatatga ttgcttcata tgtctatcag 2214481 cagcgaatta tgaaaacact taccgaagaa gaattccgcg cgggttaccg caaagcgcag 2214541 cttattgatg ttcgtgagcc aaatgagttt gagggcggac atattttagg cgcccgcaac 2214601 atcccgcttt cccagctgaa acagagaaaa aatgagatcc gtacggacaa gcctgtttac 2214661 ctgtactgcc aaaacagtgt ccgcagcgga cgcgcggcac aaaccctgcg caaaaacggc 2214721 tgcactgaga tttacaacct aaaaggcggc tttaaaaaat ggggcggaaa gattaaagcg 2214781 aagaaataaa gcaaacagct gtctggtaga cagctgtttt tatttatctt tcttccgcct 2214841 cgtatctgag cactgggtgt ctcgccgctt ttgtttcatc cattcttttt acaatcgttg 2214901 tatgcggggc ctcctgaaca agctccggat tctcctccgc ttcttttgcg atttgaatca 2214961 tagcatcaat aaacgcgtcc agtgtttcct ttgattcggt ctctgtcggc tcgatcatga 2215021 tgcattcttc aacattaagc gggaaataaa tcgtcggcgg atgatagccg aaatcaagga 2215081 gccgttttgc aatatcaagc gtacgcactc ccagcttttt ctgccgcttc cctgataata 2215141 caaattcatg cttgcaatgg cggtcaaacg gaagatcgta ataaggcgcg agttttctca 2215201 tcatataatt ggcgtttaac actgcgttct cagtaacagc ctttaatccg tcaggcccca 2215261 tggagcgaat atacgtatac gctctcacat taatgccaaa gttgccgtaa tacggcttca 2215321 cacggccgat cgcatgaggg cggtcataat caaacgtaaa gcgcccttct tttttgacta 2215381 aaactggctt tggcaaataa ggaatcagat cttgttttac gccgacaggg cctgagccgg 2215441 ggcctccgcc gccatgaggg cctgtgaatg ttttatgcag gttgaggtgc accacgtcaa 2215501 atcccatatc accaggtctc gccttgctta aaacggcatt taaattagcg ccgtcataat 2215561 acagtttccc ccccgcttgg tgtacaattt ccgccatctc tgtaatctgc tcctcaaaca 2215621 agccgagcgt gttcggattc gtcagcataa gagctgcagt ttcttcattc actgctcttt 2215681 ttaaatcctc taaatcaaca agcccttttt cattcgattt caccgtaacg gtttcaaagc 2215741 ctgctactgt tgctgatgca ggattcgtcc catgcgcgga atcagggaca atgaccttcg 2215801 tccgcttgaa atccccgcga gcttcatgat aggcacggat catcatcagc cccgtccatt 2215861 cgccgtgcgc tccggcagca ggctgaagcg taacctcatc cattcccgtt atttcttcaa 2215921 ggtgtttgct taaatcatat aaaagctcta atgcgccttg caccgtgtct tcatcctgaa 2215981 gaggatgaat cgcagcaaaa ccaggaatac gtgcgatttt ttcattgatt ttcggattat 2216041 atttcatcgt gcaagaaccg agaggataaa aaccggaatc caccccgtga ttgcgtttgg 2216101 acagcgctgt ataatggcgc atgatgtcca gctctgaaac ctccggcagc gctgcgtctt 2216161 cgtcacgaat ataggtgtct gacaagaggt cccccaattc gatttccggt acatcgagct 2216221 ccggcagact atagccgatt cggccttctc ttgaaagttc aaaaataagt gcctggtcct 2216281 gattactcat ggcgatcccc caattcctga atgagtgcgt caatttcttc ttttgttctc 2216341 agctctgtta cagcaatcag catatggcag tccagctctg gatacgtcaa cccaagatca 2216401 tatccgccaa tcatgccttt tgccagcaaa cgcttgttca cagctctcac cggctcatcc 2216461 agtttgatga caaattcatt aaacatcggc ccgtcaaaca taacagtaag gcctgctttt 2216521 tttgcttctt gctttgcata gttggctttt aagagatttt ggcgggctat atcttttacg 2216581 ccgttttttc cgagagcagt catggccact gatgctgcca gcgcatttaa agcttggttc 2216641 gagcatatat ttgatgttgc tttatcccgg cggatatgct gctccctggc ttgcagggta 2216701 agcacaaagc ctctttttcc gttttcgtct tccgtttgtc cgacgagacg gcccggcacc 2216761 tttctcatta attttttagt aacggcaaaa aagccgcaat gcgggccgcc gtatgctgaa 2216821 ggaatgccga aaggctgcgc atcaccgacg acgatatcag actgaaactt gcccggcgga 2216881 gtgagaagac ctagcgccag cgggttggct gaaacaataa acatggattt cccttgatga 2216941 gcgataggct caatatcctt tagcggctcg atcctgccga aaaaattcgg gtactgaacg 2217001 atcactgcgg ctgtgttctc gcaaacggtt tggcgcaatg catcaagatc cgtaacgcca 2217061 tccgcagcgg gtacttcaac aacatcaata tactgacctt ttgcgtaagt tttcagcacc 2217121 tctcgcgatt caggatgcac ggtttttgac acaacaattt ttttcttttt cgtgtggcct 2217181 gaagcaagca ttgctgcttc tgccaaggct gttccgccgt catacatcga ggagttggcg 2217241 atatccatgc ctgtcagttc acagatcatc gtttggaatt caaaaatagc ctggagctct 2217301 ccttgtgaaa tctctggctg ataaggcgta tatgcggtat aaaactcaga gcgcgaaatg 2217361 acatgatcca caatgacagg ctgatagtgg tcatatacac ccgctcctaa gaaagaagcg 2217421 tattgtacgg tatcacgatt tttagaggcc agctttgtca gttctcttgt taattctgtc 2217481 tctgatttcg cttttttgat ttgatgctct tttttatatt tgacgttttc cggtatatca 2217541 gcaaataaat catcgatgct gcttacgccg atagtagcaa gcatctcctg tttatccttt 2217601 tctgttgcgg gcaaataacg gtgcttcatg tgttgtctcc tctctccaag aaaaaatatt 2217661 agcgtttata aaatggtgtt ttgacaacct ttgctttcac taattttttg cgtatctcta 2217721 catctacaac agtcccgatc tcactcgttt ccgaatcaat taaggcaagg ccgacgtttt 2217781 ttcctaatgt cggtgactgc gtgccggttg tcacctttcc gacagacttg ccattttgga 2217841 aaacctcata tccgtgccgc ggtatccctt tttcaatcat ttcgagaccg acaagtttgc 2217901 gcttcgctcc gttttctttt tgttcactca atactgactt accgaaaaag tcagactcct 2217961 ttttgtgctt tacagcaaag cctatacctg cttcaatcgg tgtaatatcc cgggtcagct 2218021 cctgaccgta gagcgggagc ttcgcttcaa accggagtgt atcacgtgca ccgagaccgc 2218081 atggaatcaa tccgtatgca tcccctgcat cgatgatttt tttccaaata tgcatagcat 2218141 catcactgcg gcagtaaatt tcatacccgt cttctcccgt atagccagtg cgtgaaataa 2218201 gtgctttgcg gccgctgata tcggcttcat caataaacgc aaacggcttt aatgcagaca 2218261 catccgcatc tgtcagattt tttaagatcg cttctgcttt cggtccctgt acagccaaga 2218321 gcgcgatttg atctgactga ttgtcaatct gcacatcacc tgctgcatgt tctttcatcc 2218381 aagccaagtc tttatctata ttagaagcat taatgacaag cagatagcgg ttctctcctt 2218441 tttgatagat aagcaaatca tcgacggttc cgccatccgg gtaacacatc gctgtatatt 2218501 gagcacggcc tggcgttaac gcggaaacat catttgtcat caatctttgc aaaaaagaca 2218561 gactgtcgtt ccctgacact tcgacttctc ccatatgaga tacatcaaac aaaccggctg 2218621 cagttcggac agcctcgtgt tcttttttta tagaagaaaa ttgaacagga agctcccagc 2218681 ctccgaaatc aatcgttttt cctccatatt ccttatacag gtcaaataac ggcgttcttt 2218741 tcagcatcta attcctcccc tttatcaacg gcgcagctaa aaaacataca aaaaaggaca 2218801 gagaaacacc tcatgtaaaa tgaaggttct ctgtcctggc acctgaaagt ttactttgca 2218861 tacgcaaaga cgtccccttt ggtggtttgc gcatccgcac aaacactctc cagagttgcg 2218921 tcgagcaaga gttcttttgc ctgagagatt cactccgcag tttgctcctt cggcgcctgt 2218981 atcccgaggt tttcggtcag gtctctcccc ttgctgtcat tcgctcatat tttcatgctg 2219041 ttatggacat actatagcaa tatcttacat caaatacata ctcatatcct accatcatca 2219101 ctatatgctg ggcaacagca atttgggcag atttttctta tattattcat cttaagaatc 2219161 gaagaataag aaaggcggtt tcaaagcaat gaatacagaa atgatctacg atgcaaaatg 2219221 gcctgaagaa tttgctgaaa gactgaaaaa cgatggccct tgggcaaact gggaactgta 2219281 caagctctct gcagaaatcc agaaaacatt agcaattcca gagtttgaag gcttacgggc 2219341 tcctttatat ctgccttcct ttacgccgct cccccaccag cttgaagtgg cgcaaaaagt 2219401 ggttgaaaaa atgaacggga aagcgatttt agcagatgag gttggtctcg gaaaaacggt 2219461 tgaagctgga ctgattctaa aagaatatat gattcgcggg ttagcaaaaa aaattttgat 2219521 ccttgtgccc gcttcccttg tgtcacagtg ggtcaaagag cttcaggaaa aatttttgat 2219581 tccggctgtt gaacaaaaga aaagctatgt gtgggagcaa tgcgatattg tcgtctcatc 2219641 aatagacacc gcgaagcgct cgccccatcg agaaatcgtt ctgtctatcc catatgatct 2219701 tgtcattatt gatgaggcac acaaactgaa aaatagcaaa acgaagaact atgaatttgt 2219761 ccggaatctc gtaaaaaaat attgcctgct tcttaccgcg acgccaatcc agaaccgtat 2219821 cgaagagatt ttcaatttgg tgtccttatt aaaacccggc catttaggca gtcagaatca 2219881 ctttcaggag gagttcgcca agaagaaatc cagtttagaa gcgcatgaac atttaaaaga 2219941 tcttgtgaat aaagtcatga tccgtaacag gcggcatgat acagggctga attggaaaca 2220001 gcgccatgtt gaaacagtgc cgattcaatt ttctccatca gagcaggcgc tttatgatga 2220061 aatttctcgt ttgaaggaca gtatcaataa accagccagc atgttctcga ttatgacctt 2220121 gcaaagagaa tgctgttcga gcagagaagc ggtatatatg acgctgaaaa agatgcttga 2220181 tcaaaaagag aaacaagcac ctgccattga tgaggatacg atttcagttt tgatagatcg 2220241 catcaatcaa gtgacacaaa actctaaagc gcttcaagtt gttgacttga tcaaaaagat 2220301 cgacgataag gtcatcattt ttacagaata ccgcgcaacc cagatttatc tgcagtggtt 2220361 tcttcagcaa aacggcatca gttctgtgcc gtttagaggc ggatttaaac gtggaaaaaa 2220421 agactggatg aaggatcttt tccgcggaaa aatccaagtc cttattgcaa ctgaagcagg 2220481 cggtgaggga attaacctgc aattttgcaa tcacatgatc aactatgacc tgccatggaa 2220541 cccgatgcgg cttgagcaaa gaatcggaag aattcacaga ctcgggcagg agcgtgacgt 2220601 gcatatttat aacatggcga caaaacatac ggtggaagag catattctaa agcttttata 2220661 tgaaaaaatt catttgtttg aaaaagtggt cggtgaactt gatgatattt taacgaaaat 2220721 tcaagtgaac aattttgaag agcaccttca tgacattttg tatcactcag caacagaaga 2220781 agaaatgaaa ataaaaatgg ataacttaac ctcatttttg tcttataaaa aacagctgcc 2220841 tgctgaaaaa agaggatctt agcctgtaag gaggttttat tagtgagaca gcaagaggtt 2220901 cacgattttc tgctgcgttt ttttcaagca aacagctgcc aaatcgtcga tcaaggctta 2220961 ggctatatga cagtgcagct tacagttgaa atggacaaac aaatcatgaa ccgccctttc 2221021 tactggcatt ggcgcgagaa gacaggcggt gatccgaatc caatgaaaat cacttttatt 2221081 acagataaag aaaatgcgcc aaaagaccta gatggtgaat ttatatattt tggggccccg 2221141 cgtctttttc aaatattcaa agctgttaaa caaaatggga gatttaccag aatgtatgag 2221201 aaaattgaat cagccggagc taaagtccca cttcagcctt ggcttggtat aaatgtcacg 2221261 atttcatacc agtccgacat gaaaaaggat aagttattgt cactaggtct tcacctagtc 2221321 tctggaacga taattgaaga ttttcaaagc aagctgaccc agttttcact gacgtctcaa 2221381 atatgtgact attgcttcac catttcacct atgatcaaac cagaaagcgg acttaagcgt 2221441 atggaaaact atatttccaa atccgctatg caggagccgt ccgactgggc ggaacaggcg 2221501 gttaacaggt ggaagaatga tatgacattg cttgataagt tttacgagca tatagaagaa 2221561 aaaccagaag aataccatct agaaaaacag gcgctgaaaa ccttgtatca accaaagata 2221621 tcagttgaaa ttgaaaatgg cggattgttt tatctgcaaa ataatatttc aagctaactt 2221681 ttttaccatt cgacatcatt ctcgtttttt ttgagaaaat acgattataa taaaggtata 2221741 ttggaaaaaa attctggtga tttaatggca aatgacttcc agagactaat gaagcataca 2221801 ataagtcatg gccggactgg ctgaaataca taaacaagta ttttaggagg agaaactgca 2221861 tgaagaatgc aaaacaagag cactttgaat tggatcaaga atgggttgaa ttaatggtgg 2221921 aagccaaaga ggcaaatatc agcccggaag aaatacgaaa atatttactt ttaaacaaaa 2221981 agtctgctca tcctggtccg gcagccagaa gtcataccgt aaatcctttc tgaatgtgct 2222041 ataatatcac aaggaaggtg atgacattga ttggccagcg tattaaacaa taccgtaaag 2222101 aaaaaggcta ctcactatca gaactagctg aaaaagctgg ggtagcgaag tcttatttaa 2222161 gctcaataga acgaaatcta caaacgaacc cctccattca atttctcgaa aaagtctccg 2222221 ctgttctgga cgtctcggtt catactttgc tcgatgagaa acatgaaacc gaatacgatg 2222281 gtcaattaga tagtgaatgg gagaaattgg ttcgcgatgc gatgacatcc ggggtatcga 2222341 aaaaacaatt tcgtgaattt ttagattatc aaaaatggag aaaatcccaa aaagaggagt 2222401 agtgcctgag cagaggcact aactcctctt ttgtcaataa ccatcgagac ggcccagtat 2222461 atgaatactg ggccgtctct tttttttgct gttattaatt tttatcctcg ctatgcgctt 2222521 tttcattttc tttcacgtaa ccatctttat cagtatggtc ctttttgatt gtcaagccgt 2222581 tccactgtgt agcttcgaat gagaattgaa gcttaatgga gttgccttga tatttatttt 2222641 gaaccataag ccctttttca tcttttgttt tatcatcctt gaattggatt tccatttgaa 2222701 cctgatcgaa gtcagttggt gtttttggaa caccatcata ttcaggagcg gttttaccat 2222761 caattgttgc tacattgact ttaccgcttg catttaagaa tttagggtca atttgttttt 2222821 tgattttttc agcagccgct gcatcatttt tagcagacat caaatacaag tctttaaggt 2222881 tcgcatcatc taaaataatg tttttcgggt agccattgcc gccctctttt ccaactgtca 2222941 acaatgtcac ttcaaactgg ctgaggaaat cttctggaga tgtattgctg ccgccgtttg 2223001 ctttaaaatc tccataatta agcgccatta gaacttcttt gatcgcaagt gatccgttat 2223061 tttcaaattg gaaatccttt gtcaacttat ctcccggctt tagatttgat aagttcacac 2223121 tcgctgaatt ctctttagca gataaatcaa gcgtacctga tgcaaaagta gcatcctttg 2223181 atttaatgtc gttaaatgct gcccatgttc ctcctccaac taaagctaat cctagtgctg 2223241 cagaagcaac tcctaaactc aatttctttt tcatacccat ggtaagctcc ccttttattg 2223301 aatgatttta tatcgaaacc tgttgccagg tttacaactg aagttaagta gacatggtgc 2223361 tgtcctttgt atctgtttcc aaggcttttg tctttctttc aatttctcta atggcgctgc 2223421 tgatcgtcac aaaagcgtaa actaacagca tcacgccggg aacaatcaat aatacagccg 2223481 ttccaatcgg ctggctggca aaatgaagca tatagccggc atatggaagc tgaaaacctg 2223541 tgtattgcgc gcgaacattt tcgtccgata caggcgctga atcagctgct gcattattat 2223601 caccttttgt tttaaataac aaatggtctc cttgctttgt tatgtcaaca attctgtggg 2223661 tgaccgccgt atttgcatcc tgcataaatg taataacgtc acctttttgg agctctttca 2223721 catcagtgat ttctttgacc aatattaagg aacctgtatt gaactccggc tccatcgaac 2223781 ctgacagaac tgatttcagc gtatacccaa acactgccgg ctctcccccg gatgaacgtg 2223841 ttgaaatcac gacaagtgtc agcacaataa taagagtaaa gatgatcacg tataaaatat 2223901 tactgatcag cttcattgct tttttcatcc tcttccccgc tttccttctg gtctgattga 2223961 gtttcttttt ctttggttac agcttcttga gatgtttctt ctttcattgt tttttccggt 2224021 atatcttttt gtgttgtttc attctccttt ttgacgtccg actttgtttc ttttttaggg 2224081 actgtcggtt tttcatcgca ttttgcaagc ctcataggct ccgaccactc aaatgtactg 2224141 ccgtttgccg ggtagcctgc cggtttatat actttaaatg cataaatgcc gggtttcatt 2224201 tttttcttgg tctcaatttt ataaagtgaa tcgccgattt gattggagac aaatcctttt 2224261 tcgatcacgt tcccatcctt taacggtttg cgggcatttt caagcttatg aagctcccac 2224321 ttccactttg atttcttaag tttctcacct gtattttcga gcacagcaaa taaggcgaaa 2224381 ggtgagcata cagtgccttt cgtatccgtt tgatctgata tgtgcaaatc actttgatcc 2224441 cagcgtttat cataatggca gtttttatct gtatgctgaa agtctttaca cgtttgaagt 2224501 gagacatcaa atgtttcaat atcatgaaaa gcagcgcttg tatcatcgga aaattgtaag 2224561 catattgcgg cagtcagact gaaaatgact gaaagctgaa agataagcag aactttcagt 2224621 ttcgtcttcg ccttttgctg attgtgaaac aatcgaaaca tatcttacct cctgtaaaac 2224681 actgtaactt gatatgacaa tcgttctctt taaagaactt cacaaataga gtataatcaa 2224741 cgatttatag atttaaaaac accgaaatcg ctcattttgt tcgtttaaaa gaatgttttc 2224801 atcatattac aaagtcttgc tcagtattgc tcattttttc aattttttag aaatttttgg 2224861 gattgttatg tgagaattta aatgcatatc ccattattat ttggtaataa taaacaaaga 2224921 aagggtgaca gcatgatgat caaacaatgt gtgatttgtc tatctcttct cgtctttggc 2224981 accacagccg ctcacgcaga agaaacaccg cttgtaaccg cccgccacat gtccaaatgg 2225041 gaagagattg ctgtaaaaga agcaaaaaaa aggtacccgc tcgcacaggt actgttcaaa 2225101 caaaaagtat gggaccgtaa aagaaaagat gaagcagtga agcaatacca tttaactctg 2225161 agggaagggt caaaagaatt cggcgttttt gtgacgattt catttgatcc ttatagccaa 2225221 aaggtcaata aaattgccat attagaagaa tatcaataag gtcctccatt ttttgaagga 2225281 ccttattcgt ttatttgcgg ttattttttc cgtttcagcc aaagtcggaa gccatagggt 2225341 aaaataccga accactgctg ggaaacaggc gtttttgttt ctttccgcac ctcttttcgt 2225401 tcttttcgct catctctcgg agtatctata tatttgacaa attgctgcgt catatattta 2225461 acataatcat tcgttttcac gtgatcacct catcattcaa ttattatgag tgttgtctca 2225521 catgactttt tttataccct ttacactgtt ttattctgtc catctcagca gttttttctg 2225581 tttttggtca aacacgatct gtgcagttct ttctgttccc gaatccgttg acactcttaa 2225641 gttgatttct ttttgttctt ttatcgatgt atcatgaatg taataagaaa cccgtccata 2225701 tagaaattgc tgcgtaccct cctggccttt ccgttcctct agaacatgcc gaatcgaaag 2225761 aagcacccca ttttgaagca aattctctcc tatgtataac tcttttgttt ccttctcaaa 2225821 catgcagcgt gaaatatatt gagcagcaac aaagttcacg attaacagca caagcgctga 2225881 cacaaaaaga acagctggat aaataaaccc tcttgtacga tacattcacc cccctcctaa 2225941 atacgaatag actggaaaag cagtttgata cactttttgg tcttcactct caattttcag 2226001 caaaacaaca ccattttcaa tatcagcttt catggcagta atatgatcta aaatcggaac 2226061 atgccctttg ccatccactc tttttcttat cattgaatga taaatgtcaa aacggatgtc 2226121 ttgtccggaa agattggtgc agattaacac gctcccatgc tcggctgtct taactgcctg 2226181 tgattccttg cattcattca tcatctgttc tatcgaaatc atccattcct gctgtgtgaa 2226241 accgtcatgt tcctgctgtc gagacaaaaa cagatggata atcgcagcta acgatcctga 2226301 tatgagcaaa aagactgaga gcgaaaataa tacgttaaga agcgtgtagc cattctgtct 2226361 gcaaaatgct gaggcaaaat gatttttctt tataagctgc ggctttgata catacgtttt 2226421 gatattcgcc ctcctcctcc cacttcattg catagatatg attgttcttt gtaatcgttt 2226481 ttgacgcggc tccttcacca ctcatgacat atttgctaat gctctcattc atcatctgat 2226541 agccaatttc tcgtgattcc gccatttttt catcagccat cagcttgtcc cacaagggga 2226601 cgactgtcag cagcacaaac agccacaggc ttagcgcaga cattgtttct attgtagaaa 2226661 aacctttatt ttctctccac attgactctc ccgctcccta gataaactgt tatgtcataa 2226721 acggcatggc cttttactcg tatttttccg cctgcattcg ggtgcccttt ctcattaaat 2226781 tccaaacggt cttttaatgt cagcagttct atagaaagtc ccgttgcata cggacgttca 2226841 ataaccgtat caccaatgac taattgatat tcttttttat gaaagagaat ttttgttctt 2226901 tgttgacggg aaatagcagt ctgctgtgtg agcataatat catttttcag ctgacttgct 2226961 gcctgtcgga cagctgtatt gtcataagca ggaggaagtg tagtgaagac ggccaccagg 2227021 aggatagagg caaggcttaa cacaagcaaa ctttctaaaa gggtaaaccc cttctcctcg 2227081 tttaatttaa tgttcaacct taacttctcc gccggtgatg ataatgcgct taccatttgg 2227141 acagacagca tcctttttca catagccctc tgactgtaaa tcggcaaggc tcggagtttg 2227201 tccttcatga tcaagctcaa atgcagtcat ttgtgcctta accatgtttt gtaagccttc 2227261 acagcccttt ttttgaatgg tttgattatg tttcgtgacg ttcggtatcg taattaaaag 2227321 caaaatcgaa ataataaaga gcacgattaa catttcaaca agtgtaaatc ctttctcatt 2227381 catcagcctc ttcctttcac atttgattca tcatctgata cataggcaca agcatagata 2227441 aatacacaag taagatcatc gctgcaacaa atccataaat cattggctga aggatgcctg 2227501 tccatttttg cgctttgtgt tccagccgct gtaatatgaa ttggctgtat gtgaaaagct 2227561 cccgatccaa tcggccgctc agctggccgt gagatatgac ttttgataaa tcagtttcat 2227621 aaaaaaggct tccacaaata gcggattcaa ttgactcacc ggcttttagc cgttcaatca 2227681 attgttcagc ctcgcagcgg tagaaaggga gaaacgtttg atgtttaaat gcattaaggc 2227741 tgtcataaat tgagaggcct gattttaaaa ggctgcttag ctgcaaagaa aaaaagtagc 2227801 tgttaaacag ctttacaagc tttccaacca aaggaatcct gatacaaatc agcatttgcc 2227861 gggcaggtga ttttttctta aacacaagcc aataataaat cccgatacct gctgtaaaaa 2227921 gaacaagcaa aatgatcaca agatcaatat gctgaaaaaa agcaaaaagc atatcggttg 2227981 aacgtgaggt ttccatattc atcgattgat agataccgga aaactgagga atgatgatgg 2228041 actgtaacat ataaaacatg acagcgaccg taaagatgag gaaaagcgga tagcgcagca 2228101 ctcttttcag ctggtctgcc tgtgcaattt ttcgttccag cagctctccg ctctggatca 2228161 ttgaagcagg cagttcacca tgtgtttcag caaaataaca aatacctacg gcttccttat 2228221 gaaatgacaa actctttagt acttgataaa acggagcccc ttccctcaaa caagtgaccg 2228281 aatcagtcaa gtcagccgcc tgcctcttat tcatctgaag ttccatcagg cgtaatccat 2228341 ccagaagtgt atatccgccc gcagtcattt caccgagcct ctttaataac ctggcttgat 2228401 cctttaacaa ccagactttt ctaatctttt tcatgataaa cccaccggtc atagttgttt 2228461 gtcgttaaat agccgagcgc aattcctttt ctgataattt gacgaagcgt ttgatattgg 2228521 taatttgcat gatttccttt tgcctcctgg atacattgct gaagattttt cccgtataga 2228581 agctcataaa cgctagctct cctagtattt cgtgactgtc ggcaatacac tgatgaacat 2228641 ccgttttcac aaaacgggca agccaaatca accaagcgct gagccgctat tgcaatgaca 2228701 gtctgttcga tttcattcat attgataccg aattcaagca gtctgtaaat tgcgcccttt 2228761 gcgtctctcg tatgaaggct cgttagtacc agatgtcccg tcatcgctgc ccgcaccgca 2228821 atttcagctg tttccgcgtc tctgatctca cctaaaataa tcatatcggg gtcatggcgc 2228881 aaaattgctt tcagacctgc ggaataagtt acaccggctt tttcattcac ctgaacctga 2228941 agaacatctt cgtcccttgt ttcaacaggg tcctctaatg tgacaatatt tcgattaaag 2229001 tgtttttttg catattgaac gagagagtat aatgtggtag tcttccctga accagtcggc 2229061 ccggtaaaaa tgagcatgcc atgggaatgt tttaaaaacg agagtaatgt ggctcctgtc 2229121 ttcggaaata gcgacaattt atcaatcgaa gggatattgt attggggcat cactctgatc 2229181 acgaggcttt cttcattaat tgtgggcagc gttgacattc ttaaatgaac atttccctct 2229241 ttcaacttta acgtaagcga accgttttgc ggctttcgcc tttcacctat atccattgct 2229301 gaaagaaatt taaaatgtga aatcagtctt acgcactctt cttttttcat gtcccttttt 2229361 ttcagcaagg catgatcgac ccgaaaatga atgatagcgt cccgctccct cggcacaatg 2229421 tgaatatcag aagcctttgt tagatatgcc tcttcaatca agtttttgct taccttttct 2229481 attgaatcca atttgattcc ctctcctttc aacgcatatt gtagaaaaag aagaaaaggt 2229541 aatcaaacag ggaaaacgtg attttgtgag atgttatatg ctgaaaaacc aattctttct 2229601 ggcaagaaaa aagactttca actgaatgta cccctgtcat tataattttc cctataaata 2229661 aaaaagcaga catggtcacc atgcctgcta gattccattt tcattatgct gttttcgctt 2229721 attgaccagt atctttctca acggaaagat cgcctaatgc aacaataccg gtcatttggt 2229781 cattttcaag aatcgataaa ctgcggattt aatgctctgt cataagcccc ttgacatcgt 2229841 atccggtcac cctgatatgt ctggtgaaaa agcggggcac gctgcacaaa atatgaaaca 2229901 tcctatagag tccgcctttt tcgaggtttc tttttcttct tccgctcctg cagcatatct 2229961 cccgtccagc ctttttttct caaatagaga tagatcagaa ctgtagatgt gacaatcaat 2230021 aagagggaaa agagatatcc gtatttccaa ttcagttccg gcatcactga aaagttcatc 2230081 ccccataagg cacccagagc tgtaatcgga gtaaaaagcg tcgtgaaaat ggtcagcgct 2230141 tttacaattt cattccccct atgtgaggta atgacttcct ctgaatgcag cagattgtta 2230201 agctcccctt caaattcgct gatgtatgta aatcccctgt caatcttcag ttgtgtccgc 2230261 tgataatcct ttttcccttc attttgaggt aaaaaggttt ctttcaacgc catttcaatt 2230321 tttttagcgc ttaatatcaa atttttccaa atcatcagtt catggcgcag gagatggacg 2230381 cggtttaaaa tgcttttgct attgtcgtct ttaatttgcc atctgagctt tctcagcttg 2230441 acttcaaatt catcaacacc gattaaatac gcattcatta gttcgccgag aagaattaaa 2230501 aacccctcta tcgcattgtc cgctctttcc atttgccgaa caacttcttt gcctttaatc 2230561 tctctcaaaa ttgaaaagtc aaagttgatt gtaaaaaaat attgtctggt gatataaaag 2230621 tgaaaaacag tatggtcttt ttcttcacca agcccctgat cataaacaat cgacccaaat 2230681 actgcttcat tttccgtttc agttgtatct actcgcaaaa aattaacgtg atggttattt 2230741 tcaaaccact tttcacactg aggccagtga gaaaaatgga ttagatctct tgccttactt 2230801 ctttcttgag gccccatttg gtaccaaaac caatcctttc ccgtatgtgc cttcatgtca 2230861 agctcctcca aacttttgtt ctttattctt taattgccca ataaccgcgt cactaaacca 2230921 gtctgccgct tcaacacatg ttttatgagc attttcaggt ggtatggaat gtagaaagac 2230981 atcggaaaag ggaggtgcat gccttccttg gagaaggcag ttgttttgga atttatcaat 2231041 ttactagcag tcgctattct cattttgtta acaggatttt tcgttgccgt agaattttca 2231101 atcgtaaaag tgcggcgatc caaaattgat cagcttgtcg caaaaggaaa gaaaggtgct 2231161 aaagcggcaa agcatgtcat cactcacctt gatgaatatt tatcagcctg tcagctgggc 2231221 atcacagtcg cagctttagg actgggatgg cttggggaac cgactgtgca aactctgctt 2231281 cgaccgcttt ttcataaagc aggcttaaat gaatcgctta cccacctgct ttcactcgtc 2231341 atcgcatttt tagtggttac gtatttaaat gtcgttattg gggagctggc gccaaagagt 2231401 ttcgccattc aaaaagcaga aagcattacc ttgttgttcg ctaaaccgct tatttggttt 2231461 tataagatca tgtttccatt catttggctg ttgaaccact ctgcccgatt gattacagga 2231521 gtgtttgggc tgaagccggc atcagagcat gagctggctt atacagagga agaacttcgg 2231581 gtcctattgg ctgaaagcta taaaagcggc gagatcagaa aaagtgaatt aaagtacatg 2231641 aataatatct tcacctttga taaacgaatg gcaaaggaaa ttatggtgcc gcgaaatgaa 2231701 atggttagtt tgtcactaga tgaagactcc atttcaaatc ttcaggaaac agtcaagcaa 2231761 acaaaatata cacggtaccc ggttgtaaga gaggataaag ataacgtcat tggcgtgatt 2231821 aatatgaaag aagtgctgtt ttccatgctg acgaaagatt tttcaatcaa gaagcatcaa 2231881 attgaacctt tcgtacagcc cgttatccat gtaattgaga cgattcctat ttataaacta 2231941 ttgctgaaaa tgcaaaagga acgcactcat atggcgatcc tcatagatga atatggcggg 2232001 acgtccggtt tggtcactgt cgaggatatt atcgaagaaa ttgtaggaga aatccgtgat 2232061 gaatttgatg cggatgaagt gcctcatatc cgcgaacttg gaaaggatca ttacttgtta 2232121 aatgcaaaat tattaatcag cgatgttaac agcctgcttg gaaccgattt atcagaggct 2232181 gaagtagaca ccttgggcgg ctggtttttg acacaaaaca tagacgctga gcctgaaagt 2232241 gccatagaat atgatggcta ctcttttaag gtaaaagaca tcaacagcca tcacatttta 2232301 tttatagaag ttaaaaaagc tgaatagccc gtgaaaggct gttcagctgc tatctttcaa 2232361 gataaacatg gcaaaggcat caacactctt ttattttaaa ccctttattg gccagggctt 2232421 tagcaagact ttgctctgtt ttcacattcg aaaaatccag acccagcttc acgacagttt 2232481 gggcaatttc cggcctgatt cctgaaataa tagtctcaat gccgagcaat ttggtgctgt 2232541 caatcacttt aaaaatttga taggctacca tggtatcaac gataggaacg cccgaaatat 2232601 ctaaaaataa atacgagagc tttaacgctg agcactgctc cagcacagac tccaaaatcg 2232661 tcctcgctct gtgcgtatca atttcaccga caagcggaag aatcccaatt ccatcagtaa 2232721 tcggcataat cggcgcactc aattcattaa tcatttcttt ttgcgcgttt aattgtatca 2232781 tggtcacctg gtgatattct tccgtaaaca cttcgatgat ctcatcaatg ttttgattca 2232841 agatccggct ccactcataa aattcctgaa tgctgatgtc ttgagaagaa gcttcgctga 2232901 atttatgaat ccattcaaac atgatgtgcc tgaaagtgtt aaactggccg acactttgtg 2232961 taaccgtcac ttcatgaacg gcacggtctc tggcgcattg aagagaccac cggttgagct 2233021 catcctctac gtcttctttt ctaagggatt ttgctacgat ggtcaccaat aattcatgct 2233081 ggtcttttaa cttttgttct agtttttgct gatctttcgc tgaatacagc cagctgccgt 2233141 ttgacgtaca aacttccagc cattgttgcg taatatcttt tttgtgctct gttaagtgct 2233201 gatcaagagc tatcatctta atgagttacc tcctgttttt gaaaaatgta cgctatatat 2233261 gtataacgcg tctgccttta cacatactat gtttagattc aatgggctat agccaagcgg 2233321 taaggcaatg gactttgact ccgtgatcgt tggttcgaat ccagctagcc cagtttctga 2233381 acaggtgaaa aaccgaagat aagctgattc gtataaatca gcggatcttc ggtttttcat 2233441 catgcagatt gatgaaccgt tttcttcttc gataacttca acagttctcc cgggttataa 2233501 ccaatcacca gctttttgtt gtctactaga atcgggcgtc gcaaaagctt cggcttctcg 2233561 attaaaagtt ccagcacctc atttaccgtc atttcttcaa tgtttaaatt taaatttttg 2233621 aaagtctggc ttcttgtcgc caaaatttca tcaattcctt ctgtcgttaa cgataaaatg 2233681 tactttaatt cttctcttgt cggggtttct ctgaataagt gccgttcgtt aaattcaatt 2233741 tgatgtgctt taagccaatg ttttgttttt cggcatgacg tgcagcttgg atatgagtaa 2233801 aaagttaatt gttgttccat tcgttttttc ctcctcagtt aaccatctct ttgtagaata 2233861 actacccgga tcatttttca tttaaaccat ttacagaact tttttcggat tattttttaa 2233921 aaaacattca tacaatagaa aacacaatca aagggacaaa ttccatttgt atattaataa 2233981 tgaaaatgtt tacatttcta ggtgtgatct attataataa cagtcagagg gactctcggg 2234041 aggggataaa aatgaatcgc atgttccggg tgttaggatt ttggacggga atttttgcag 2234101 tcatgtttta tttaggtgat atgaaagatg cttccctttt attttttgga cagacgatct 2234161 tatttgtgtt tctatcgtat ttgaacttaa ccgaacgcat gtatatttat atttttggcg 2234221 cttatttaac aattttcttc gccggcttta catattactc aatttttatt atggtgcccg 2234281 gcggcggagg ccattaaatg cagaaagaga caaaccttat cggtttgtct ctttttttac 2234341 aatgaaaacc catttaaaaa cggattttga tcctgctcag tcagtacgtc tgtttcaggt 2234401 ccatggccgc ttaacaccag cgtgtgttcc ggaagcgtaa gcagtttttc atgaatggac 2234461 gtcagcagcg tctcttgatt gccgcctatt aaatccgtac gtcctatacc gccttggaac 2234521 aagacatctc cggaaatgac caagtctgca tctttcacgt agtaagacac actgcctggt 2234581 gaatgtcccg gcgtaaataa tgtttccaaa tgaaacggcc cgatattcaa ctcaccgtcg 2234641 ccttcaatta gatgatctgc aggcttagct gtgacttcta tccctcgcag catgccggag 2234701 ccgtttaaag aagcgtccgc aagccaattt ttttcatttt gatgcaggta aacagggata 2234761 tcccattttt ctctcacttc atcaagcgcc ccaatatggt caaaatgggc atgtgtaagc 2234821 aaaatggcta aaggcgtcag ccctttttct tttatgtatt gattgatttt atgtccctcg 2234881 ccgcccggat caaaaatcag acattgatca tcactgatga gaaaatatgc gttcgcttga 2234941 atcggcccta ctggcattcg tctccatttc actattatca cctctttctt ttttatgctc 2235001 ttattatgag ggtttttgaa aaaagattca aacaatcgca atgaaaacgc tatcgacaaa 2235061 cctataaaaa acaggtagaa taaaactgga aagaattgca ggtttttcaa tgtaaagggg 2235121 gctgtgttat gttacttgtc gtgattttcg gccttgtcgc tcttttcgct ttatggggag 2235181 tcttgcgttc tgttagaaat aaaaatatac tcgggttttt attagccggt gccaccttat 2235241 ttgtctttgg atggtttacc gtgatgaccg taataaacag cgggtatcca accgcacatt 2235301 aaaacctgta tccgatcgga tacaggttta tttttatggc tgtaaatgtt tattgacact 2235361 ttctattttg ctctcaagcg tcgttttttt gtcacgcctg tcatcgatac ggatattcgt 2235421 tgccactctg tgcaatcctt tttgaaatgg cgcttcgtga attgcctgaa taactgcaaa 2235481 aaggtcactg agttctccct cgatcagcgt attcatcggt gtcagctgat atttgatttt 2235541 cccttctgct tgatatcctt ctaatatctt ttgcacatcg gctacgtaag cactgacact 2235601 gggtgtttcc gtaccgattg ggataatggt tacatctgcg atagccatcg ttattccatc 2235661 tccttttgat caatgatgag ttgcttcgtt tcatgtgatt tcaataaaat aatttgctca 2235721 aaatgaaagc cgtataacgc atatttcccg ttcggagata tttgaatcgg ctccatttcc 2235781 cgcagagaca caagatcttt tgtctctccc gatgctacat tgattgctgc gagcttatat 2235841 gcatcgccgc tttgtttgaa tgtataaaac aggcctcctg cttcatcata gtcatactcc 2235901 attggagcca aacttgtata tttcgcttgg agcggccatt tcgctgtaac aggtgatgtt 2235961 gattgcggcg ttttaaactg atacgtccct tttcctccgg aagctgattt gacagtaaaa 2236021 ctcatttgat ggaaagaatc gaagaataga acgttatcct caagcttctg ttccgtctta 2236081 gaagctgtat cgaacgtata taaaggccct gttttatcgt ctctaccctc ttttacataa 2236141 tcaaatgtat ttttggatgt ccaatgaatg aacggaacct gtactgggct taagaaagat 2236201 tcgtcttttt tagcattcac ctgatatgta tggaaatccc agttttcatt gaattccgtc 2236261 accatcattt gataaggatc atactgattc caagcagctt caagctcata cgtttcgtaa 2236321 tctttttcgt aaagcgtctc tccttctgca ttaagcaaaa ccactgccgt cttttggcta 2236381 tgtgtgattt gcagcagaat catctgctcc ctcgcattga tttgaacatc aacgatttga 2236441 ccatccgttt gatagagctt tttcgctttg cctgtaaaga tgcggtacgc aaaaagctct 2236501 gttttcgtcg gattagacgc agtatataat attgtgctgt tattcagcca gccttccgcc 2236561 ccatccgctt tttccgcgga aagcggtatg atgtcttttt tctcatcttt tgccgccgat 2236621 gcctgttttt gctgctgatg agatggttcg catgccgata aactaaacag caataccgcc 2236681 agcagaataa aacaaactga tctcatcagc attcccctcc gatcatcttt attctctcat 2236741 atttgcttcg gcagaaaaaa gaaaaagttt cagttactca tgaaaaaata acgccctcca 2236801 caagataccg cttgtggcgt tatatatgtg tgaaaactgc tgaaacggca aaggattttg 2236861 gccttttcca agttccaccg tatacccttc cttaaaataa tggtgaataa accaatcacg 2236921 aaatccagca tagctgtcta tatcccttac tcccttataa atgttcccgc ttaactcctc 2236981 aaactccttt atgacggcag cagattcctc aggctcaagg cctttatagc cccaataaat 2237041 ttcttctcct tgagtatgaa gagccagcag tctgtcaggc ggattctccg tgatcagccg 2237101 gtacatcgca atagattccg gctccgtaag cggagagatt cccggaaaat cgcggtagct 2237161 gggtgctgtc ggttttcggt atttttcaat ttcccataat gatggaaatt gtttatttaa 2237221 atcaaccccg tttatattcg ccttccattc attaaaattt ggacgatgtt catttagcct 2237281 ttcgagttca tctcttctgg ctcccatgac ttctgatccg tttaaaacaa gatcaacgcc 2237341 atccggattg acaagaggaa cgagggataa ggatgtgctg ttaaacagct ttatgggaga 2237401 aaagccaaag aaaggcgaat tgcagcataa tgacatacag tattccttaa accattttag 2237461 caggacagac gttgtaatcc actcattcgc atgaaatgac gcgttcatat ggaccttttt 2237521 tacggcatgc tccccaccag ccttcagctc ccagataggc ctgccgagta cagaacggcc 2237581 aatttcccgg catgagacaa acggaaaaac atcaataatc ttctttattt ccttttcaac 2237641 agctgaatca tcatagattt tctcttgctc aatccagcta tctgaaagtt tcagctgccg 2237701 aggctgtaaa aagcgcttta tgtcctgaat ggtttgaagc tctttgccgc tatgctcctc 2237761 tatcacataa ccagggcaat acaattgatg tttttgtgcg gagcgatttg cacttttaag 2237821 caattcctcg tctatcttca gttctttcgc cacattggcc aaattgttct tgatctcagg 2237881 tttcaccgta ataaacgcca tcatcatccc ccttttttgt tactatatga cagcgtattt 2237941 aaaaaaagaa agcctcccgc tcacttcgat gcgggagaca ttgtgattat gatgcctgat 2238001 caagcatttg tttttctttc cgctttgacg aattgtccag ccttttctgg tcataaaatc 2238061 gcaacaaatc cccataaatg atttcatcag aaagtgatag ctcctgtttt gctttatcag 2238121 caaatgcttc acattgtttt gtctcttcta acggttttcc cgtctctttg tcataacacg 2238181 caccgtctgt ataaacaacc tgatctgtga taaagctccc gtcccggagc accgtgaagt 2238241 ccagtttttc gtctgaaagc agatcgttgc cgaattgaat ttgatctttc gtatcaatcc 2238301 ctaaaagatt catcagcgtc ggcctgatat caatctgccc gcctactgtt tcaatggttt 2238361 gcggcttttt atcagtaata cccggaatat gaatgaccag cggcactttt tggagctgta 2238421 cctcttcaaa tggggttatt tcttttccta aaaactgccc catcgcttca ttatggtttt 2238481 ctgatatacc ataatggtca ccatataata caataacaga gttgtcgtat aacccgtctt 2238541 ccttcagctt ttcgataaac cgtttcagcg cctcatcctg ataacgcact gtcggaaaat 2238601 atttatttag cgtctggctg tttgaatcat attcatcaat caattgatcc tcttcatcaa 2238661 gatcaaacgg gaagtggttc gtcagtgtaa tcagcctcga gtaaaacggc tgaggcagat 2238721 ttttcatcag ctctgaggac tgctcaaaaa attctttatc cttaagtccc cagccgactg 2238781 aattttcgtc agttacatca tacgagttaa tatcaaaaaa cgaatcatat ccaaatgagt 2238841 cgtacattaa atcacgattc caaaagctct tattattagc gtggagcacc gctgaatagt 2238901 atccgctgtt tttcaaaatt tcaggagcgg ccatatattg attgcccgca ttcgtaaaaa 2238961 atacggcacc tcgtccaagc ggatacagtg aattgtccac gataaattca gaatccgagg 2239021 ttttcccctg gcctgtttgg tggtaaacat tattaaagtt gtagctctgt tttataaagt 2239081 cattcagaaa aggcgtgatt tcttctccat tcaatttttc attaatcacg aagctttgcg 2239141 tcgactctaa ggatacgaga atgacgttcc ttccttttgc agcgccgaat aagcgtttgt 2239201 tggcatcctt cgcattagcg gttacgtagt tttcaatctc cgtcaggctg ttgctgtctg 2239261 ccaacgctct ctgtgcggat tgctttgact gaagaacgcc atcgtaaata tgaaaattaa 2239321 acaggctaat gtttttaaca agcatttctc tgtcaaatga gcgtgtcaat agctgaggtc 2239381 tttccgcctc agacaagccc aggttgaaga aataaacaga agcaacgaac aaaaaataag 2239441 ccgcccgttc atttttcgtt gagggaatgt ccgattgaaa agctttttgc cggatgtgaa 2239501 gccatattaa aaccgcaata tctacagcta ataggaggtc tgtcggctca agaagtgttc 2239561 cgatgctgct tccgagatca cccatattgc tcgtttgaaa aagaacaggg attgttaaga 2239621 aatcattgta aaaacggtaa aaaaccatat ttgccagcaa tacaaacgtg acaagacagc 2239681 tcatcgcgat aatgtagcga tttctgtttt tgccttttaa aaacaggctg aggccaaaaa 2239741 taagcaacaa aaaactcaat gggttgataa acagaataaa ttcctgtgtt agattgtcga 2239801 ttttaatatg aaaactggtt ttgtaaacag catacgtttt cagccacatc aataaaatgg 2239861 caatcagcat aaatgaaatc ttcgaaaaaa acgtttttcg catttcaacc tcctatgcag 2239921 cacgctcaaa aaaatcagtc tattcccaac attctcatta acacatcaaa ttaaatctta 2239981 acctgagcac aacaaaaaat caatttcatt tacacaattt taacaatttt gatgtttcag 2240041 ccattcattt ttagcgatcc aagcgcctcc gataacgccg gcatcatttc caagtgctgc 2240101 gattgaaata tcagcagctt gggctgcccg cggaaacgcg catttgcgga atgttttctc 2240161 gacttttgat ctcagcagtt ctccggctct cgatacgccg ccgccaagaa cgattttgga 2240221 tggattaagc gagcttgcca aatttccgag caccaaacca agatgcttgg ctacataatc 2240281 aaccacctca agggcaattt catcattttc acccgccgct tcaaacacat ctcgcgctga 2240341 caattgttcg gttgctttta aacgtgtcgt ctttttagca tttgctattt tttcttttgc 2240401 aattcttaca attccggttg ctgacgcaat tgtttcgata cagcccgttt tgccgcagtt 2240461 gcagggcgct ccgccttcag ggatgctgca aatatggccg atttctccgc cggcgccatt 2240521 tataccatgt acaatttcac catttgcaat gatgccgccg ccaactcctg tgccaagcgt 2240581 cacgagaatg acgtcttttg cgccatcacc cgctcccttc cacatttccc cgagcgcagc 2240641 aatattcgcg tcattttcta taacagctgg gatgccggtt tctgtctcca gatggttttt 2240701 caaagcataa tttttccacc ctagatttac tgtttcataa accactcctg ccgccatatc 2240761 tacagggcct ggtgcaccca ttccgatgta tttgatgatg tgcttcggtt tttgcagctc 2240821 atccagcttg ctgtcgattg tttttgcaat tgtgacagta atcgtgtcgc cggttttatc 2240881 tgtcggaact tcccacttat gctgaatttc gccatattga ttaataaaag cgagtttaat 2240941 cgtcgttcct cccaggtcaa tgcccgcaaa ccatatctcg tccattttta tcaccttagc 2241001 ctttataaaa atctcttccg ttttttgttt gttccaattc ttttcgaagg acagctgccg 2241061 ctctggccca ctgctccttt tcaatcatgt ggttcatgta taattccttt aattcatcca 2241121 gcataaactc aatttcaagc tctctgtctc caaaataaac aatgtggcca aacgttttta 2241181 acagctgctg cacatcataa aatgtattca ttttcctcac catttcttga acttaactat 2241241 cataagcgta ttcataagga agcggtcagt caagaagaaa acgctgacaa aaaagccagc 2241301 ttcctttcca tattccacct ctatgattct ttattgtttt caatttgccg ctgcagctcc 2241361 ttgtagcgct gctccttcgg cttcagtttc acagccgtct ggatggcctt ttctgcttgt 2241421 gcaagctcat ttttttccgc atacaataac gctaaattgt aataggaagc atggtcttta 2241481 ggttcttttt tcactgctcg ttccaaaagg gaaaccgcct gatcatattc gccgatttga 2241541 atatcagaaa cagcaagaat tttcaaaaga tcggcagagg catctttttg cgctgcttct 2241601 ccgttcagca attctgttac ttcttcatac tttccttcct gatacagctc gcttgcctgc 2241661 tgaatcagcg ctgactcctg gtgtgaaggc gaatgcaatc cgtaatataa aaatccaaca 2241721 gccaaagcaa tcagcaaaac cgctgacaac aatctttttc caaaggctcc ggctttaggc 2241781 aaccccagtg ctgctgcagc gaaaaagccg ccaatcaagc cgccgatatg tcctgaatta 2241841 tcaatattcg aaaccgcaaa accaaagccc agattgatga taataatgac aataatattg 2241901 gttcctatag ttcttaaaaa catttttcga ttagacaaag caacatacag taatgcacct 2241961 aagcatccga atatggctcc tgatgcccct gccgaaggat acgggctgaa cacaaaactc 2242021 gcaatcgaac ccgtaatgcc agcagccaga taaatcagca aaaatctccc cgatccatac 2242081 atccgctcaa ccgctgtacc aaccgaccat aaagccagcg tattaaaagc taaatgcgct 2242141 atgccgatgt gaagcacgat cggtgtcaga agccgccacc attctccttg tgcaatcagg 2242201 ctgttttctt ttgctccaaa agccaccagt gtctccgtat tagtgctgcc tccgtttatt 2242261 tcgagcaaga aaaacatcag gatctgaagc gcaataaata aatatgtaaa agtcggtttt 2242321 ccgttttgaa aaaccgccgc ttcagttttt ctctgttctt cttgtttcag cactagcgaa 2242381 aggaagcgtt ctcgcgccat ttgcgcgttt tcaaacgaag cgtgttcctc tgaacaatct 2242441 tctgtacgaa atgatggaaa aaccgcttga agatcatctc gaagcatcgt tcctctaacg 2242501 atcgccggct caactgacac agttcccttc tcaaaagttt tttttgcaat ctcttcccag 2242561 tcatcaactg gggcttccgt tgaaaaaaac acgttcagca gcttcatcct tcgtctgccc 2242621 aattgatgtc tgactcgttc tactcgttcg gcctgctctt cgatgtctct aaccatttct 2242681 tgacggaaat caagatcgtg cttataaaga cgaactagat catgagagga cttgtccggc 2242741 gcttccagcc atatttcatc tgactcaccg gcttgtatga cgccataccc gctattcacc 2242801 aggtgcgccg caattttcca atatgtatac tccagcaaaa acatgtttac cgctccaata 2242861 gttttttttc attataacag ctggcgctcc gaaacgccta ctgaaagcaa aaaatcccgt 2242921 ttttcacggg attttagaaa gcttgctgta taaacttatt gcggataaat ggaattctta 2242981 aaaacaaatg gataaaagac cgcctgattc ctggctggct gagtacagta ttcataagac 2243041 ggtagcgatt ttgataaaac atgacggcag aaaccgcgaa aatggcatat atcaaaagtt 2243101 ttttcatgat atccctcctg ccaatagggt ttgttattct accttattta ttctcgaata 2243161 agggacagga aagttatgaa aaacaagaaa taatccgatc ctctgttatc agcttatgta 2243221 ccgggatgtc atgcggcaga cggggtacgt gcgcaaacaa ctggcactcc aaaagcaaag 2243281 agactgtctt cccttcatat tcacttaaat agcgatcata atagccgcct ccaaagccga 2243341 ccctaaaccc gttaacatca aaacaaacac ccggaacgat catcaagtca atttgtgatg 2243401 ggtttacttc ttttgttttt tcaattaccg gctcgagcag tccggcgtac acggtttcga 2243461 gctgatcatc agtctgatat gtgcgaaatt gcattttctt cgtgtccgga tggcattttg 2243521 ggatgcaaac ttgtttccct tcttcccaag cctgctcaat gacaggacgc gtcggtatct 2243581 ctaatcctct ggaaatagtg acggcaatgg tgccggcatt ttgccactcc ggcagagaaa 2243641 acaagtactt atacatacgt tccgtttttt gaagaatatc ttcatttgat aaagcagaca 2243701 gtgcctccag cgtctttttt cttaattgtg atttcatctc tcatccccct cggaatagaa 2243761 aaaaagccag aacctttttc aaagctctgg cttttttctt acacctcaaa cagcaaagct 2243821 gttattttgt ttcacggtgt aacgtagatt ttttatcacg tgggcaatat tttttaaatt 2243881 caacgcggtc tggattgttg cgtttgttct ttttagaaat atagttacgc tcaccacatt 2243941 cagtgcaagc caaagtaata ttaacgcgca ttattttccc tccaaactaa aatcatttac 2244001 ttattcagac ttatatataa taccactata atggacggaa tgctaggctg tttttcaatg 2244061 aattgctgaa ttattgaaga tacgctcata aagctgcaaa tatgatgaca taatgagtcg 2244121 ggggtggtgg agcttgaaca cttgttgtct gccagcttct tttatccggc gggctttttc 2244181 ccggtctttt aaaaaactgt ccagcagatc agcagcttcc tgtacgagcg taaaatcagc 2244241 gatgattgcc gttttgtcat gaaccgcata atcacaaaaa ccacctgact gagaaacgac 2244301 agtcagcaca ccttgttcca tgctttcttg cgcggcaagc ccaaacggtt cataagaact 2244361 agggaaaaca gccatttcac agtgagacag taacgttctg atatctttcc tatttagaaa 2244421 cggcagaaac atgacgcgat ccttcaggtt atatgccgca gccaatttct catagcagga 2244481 cagagacggc ccctccccag ccagcactag atagaggtca ggctgacgct gcttcaagat 2244541 ggcaaacacc tttaacagct gcgataatcc tttttccgga acaaaccttc catatgaaaa 2244601 gaggaatctt ctattcatgc ttctcgggat tttccccttc tcttcctcca tagatgcagg 2244661 gcttgggata acggttattt tcttatgtgc cgccttatca agagaccgct tcataaatgt 2244721 gcttaatacg atcaatgcat cagcggattc tataaggagc cgttcggtca tgagcctgta 2244781 tgggtgtggg gcttctcggc acaccttctt cctttcgctt tcaagaccgt ggattgtcgc 2244841 agcaagcgga aggccaagcc gttgtttcaa atactgggcg gcaggggcag ttgtgtcatc 2244901 atgggcatga atcagatcaa agcgtttatt gtgtgataac acatggcgaa ccattgtaaa 2244961 gttagcatca gctatgtaat cttcaaactt cgcatacgaa aacagctgcc cgctcggagt 2245021 aaaaaccgta atgttgatat gagggtttaa ataggaaatg aggcggttta aatggacacc 2245081 gagcccgctt ttcggctcat cgggatgttc gggtgaaagc atgagaatgt tcaccgttct 2245141 ttttcccctc tcccataaca ggtgtatgca gaaaattgcg cctcccacct ggtgtgcgct 2245201 tcttcaatct gaaaactgtt tatatgacga atcccatttt catcaagata gatgtcgtct 2245261 gtaccggcaa gcttgagaga gacattcatt gaattcacaa ttctgtattc agcccgatat 2245321 acagcatcac cagccgcctg tctaatcgtc cattctcctt tatcatacgt tgtgcgtttt 2245381 gtcctgacag cttcaatgtc ttttcttttg atgacaatgc gcaattcttt tatcatatcc 2245441 tgcgtttttt cgaaaaggac cgcttcagcc agccgcattg tttcttctga gatttcccag 2245501 cttacggtca aggtgtgagc gttttgaatg attatgtcga atgtgtccct aaaaaaggaa 2245561 agcttatgtc gtatattata gggaaatggg tgtttatcca tggactccta acattctcct 2245621 ttccaatcgt tcacttcgtg ttcctattaa accattacat gaagaagaag cgaagaaaga 2245681 tttctcgaca aaatctcgtt tttttcgcga attcctttag aaactattgg ttttatggta 2245741 taaaaaagaa ggataaaaaa agaatagaag gtgatgaaac gtggaaattg ctattattgc 2245801 gttgtttatc gtcagtatag cgctaattgc attctcatat tctcaaagag acccgatgaa 2245861 agatgtagaa caggagctcg aaacactgca gctttctgcg atgcaggaaa tttacaagct 2245921 caaaaagaaa atgacagtgc ttgaggaaga attactggaa acaaaccttg tcattcgcaa 2245981 atcaaagcag aacgacatca atcaaaaaat cgctaaacaa atactttcta aatataataa 2246041 cggtatgtca gctgaagcga ttgctaaagc tgaacatgta tcagtggaag acgtgaatac 2246101 gattatcaaa gataatgaga aggtgctcgt atgacaaaac ggggcattca ggcatttgct 2246161 ggcggcatca ttttagcgac agccgttctt gcagctgttt tttatctgac tgacgaagac 2246221 caggccgctg ctgtaaaaga taataaaaca gtaaccgaac aagacgtgaa caattatctt 2246281 gattctaaaa aattggtttc tgtcaaccgt gatgaatatc aaaaacttct cgattcaaaa 2246341 gagaaatcct taaacaatga cagcggctca gacacgaaat cagacaaagt caaaacctac 2246401 aagctcacca ttaaagacgg catgagcacg gcggatgtat ctgctattct tgaaaaagag 2246461 ggcattatct cttcggctca agactttaat gactatgtca ttgatgccgg ctatcacaaa 2246521 gaaattcgtg ccggcgagtt taaagtaaaa tcagacatga gtttcaaaaa gatcgtaaaa 2246581 acgttaacac gataaaaaaa caggctgact cagcctgttt ttttcatcca aactttcctg 2246641 aaatgtaatc gagcgttctt tggtccttcg ggttagagaa cattttattc gtattgtcgc 2246701 attcaacaag ctcgcccatg tagaaaaagg cggtttgatc agaaaccctt gctgcctgct 2246761 gcatgttatg cgtgacaatg acaattgtat atttatcttt cagctctaga atgagttctt 2246821 caatttttct cgttgagatt ggatctagtg cagatgtcgg ttcatccatc agcaaaatat 2246881 caggattggt cgcaagtgct ctggcgatgc aaagacgctg ctgctggccc cctgacagcg 2246941 aaagagcgga cgtatgcaat cgatccttca cctcatccca taacgccacg tcttttaatg 2247001 acttttccac aatttcctga agcttcttct tatttttggt gccgtggact ctcggtccgt 2247061 aagccacatt atcaaaaata gattgcggaa acggattccc tttttggaat accatgccga 2247121 tattttttcg caaatccacg atgtccactt tatcctttaa aatgttgctg ccattatagt 2247181 tcagctcacc tgcaagcttt acattcggcg tcatttgaat cattaaattc aatgtcttga 2247241 taaaggtcga tttcccgcat ccggatggtc cgataatcgc cgtaacctca ttttcataaa 2247301 tgctcaaatt gatatttttt aaagcatgat gctgcccata ccataagttc attccattga 2247361 cttgatatac ttcctgtttc attacagctt cggtagcaat actcattgcc gccctcctat 2247421 ccgaatttcc cgttaatata atcctctgtc ttttgctttt tcggactcgt gaaaatctgt 2247481 tcggtctgtc cgtattctac aagctcgccg tttaaaaaga atgccgtccg gtcagaaacc 2247541 cgcagagcct gctgcatatt gtgcgtgaca ataataattg agtattctct tttcaatcct 2247601 gtaattaatt cctctatttt tgcatttgaa atcggatcaa gcgctgaagc tggttcatca 2247661 agcagaagaa cagccggctt catcgcaagc gttctcgcga tgcataaacg ctgctgctgg 2247721 ccgccggata acgagagtgc ggatgaatgt aaacgatcct tcacctcatc ccagagcgct 2247781 gcttttgtta aactttcttc cacaatttca tctaaaacag ctttattccg ctctccggca 2247841 tatttcaatg catgtgtgat attcgcatag atcgatttcg gaaatggatt tggtttttgg 2247901 aaaaccattc cgatttctct tctcaagctg acaacgttaa tattgccgcc caatatattt 2247961 aatccctcat aaaggatttc accttccgct cttgcagatg gaattaaatc gttcattcgg 2248021 ttaatatttc tcaaaaaagt agattttccg catcccgacg gcccaattaa agcagtcacc 2248081 gcattttttt caatatccat gtttacatga tgaacggctt gtttatttcc gtaataaatg 2248141 gacagatctt tgacctcaag cacgtggttc tgcttcggaa caataacagc tcgctcaggt 2248201 ttttctttta ccatttgttc agacatgttt ttcgcctctt tccgttctaa tttgccgtaa 2248261 gctttttgta gatcatcgtg ccaagccatc tcgccgcgag attaaacaca agaacagaaa 2248321 tcaccagcac ggcagaacca ccgttggcaa tcgcttcagc atccggaatc attccttgtg 2248381 tattgacgtt ccaaatgtgg accgcaagtg tttcagcggg cctgaaaata ttaagcggtg 2248441 atgtttccga aaacgggttc cactccgtaa aattaagacg cggtgttgtc aggcctgccg 2248501 taaataataa tgcggccgct tccccgaaca cccttcctga cgctaaaatt gctcctgtga 2248561 tgatagaagg aatcgcactt ggaattaaaa ctgtttttac ggtatgccag cgtgatacac 2248621 ctaaagcgag agaggcttcc ttcagatctt tagggactga acggatcgcg tcttctgtca 2248681 cacgcaccat gacaggaagg ttaaaaacag ttaacgcaag cgctccgcct atgatcgtat 2248741 aaccccagcc tgttaagttg acaaacatca ataatccaaa catcccaatg acaatagacg 2248801 gaagagatga aagcacctct atacatgttc taatgaagtc agttactttg ttattaggcg 2248861 cgtattcagc catgaagact ccgccgccca caccgagcgg gattgtaatc agcattgtaa 2248921 taaacaaaat ataaaaggag ttaaacagct gatctcgtat gcctcctcca gctgcaatgg 2248981 cgctcgactt tgttgtaata aattgaaaac tgagctgaga aacaccgttt ataataatat 2249041 aggaaaacaa acctactaaa atggcagcga taatggctgc acacaaacca aacattccgg 2249101 tcgccagttt atctgttatt ttgcggttca ttacactttc ctcctagatg acaagtagcg 2249161 aataagcagg atgaacaaga atgacatcac cagaagcaca agccccattg accacagcgt 2249221 attgttttca acacttccgt atgtggtgtg gcccatattc agcgtgatga tcgttgtcag 2249281 cgttcccgca gtgtcaaacg ggctttccgg caatactctt gtatttccaa tgaccatctg 2249341 aacagccaaa gcttcaccga acgcccgagc catgcctaac acaacagctg tcatcaatgt 2249401 tggaaaagct gcaggcacaa gtacttttct gatcgtctgc catcttgtgg caccaagcgc 2249461 gtaagaaccc tctcgtaaac tcttcggaag agaagccatt gcatcagcag aaatcgatgt 2249521 gatcgtcggc agaatcatga cggaaaggac aatcgttccc gccaataaac tgtgccctgt 2249581 tccgctcgat ttgaactggg cgataaacgg caccaatact gtaagaccta tgaatccata 2249641 aacaacagat ggaataccga ctaaaagctc aatcaccggc tgcagcactt tctttcccca 2249701 attcggggca atctctgtca taaaaatcgc acctgcaatg ccaagcggcg cagcgattag 2249761 agcagaaaga atcgttactg caaatgagcc aaaaataaat ggcagcactc cgtatttcgg 2249821 atcactatct gtaggattcc aatttaagct cgttaagaat tcaattgggc ttacaccatt 2249881 tacaagaaaa gattgcagcc ccttaacgcc gaggaaaatg gtaatcgcaa cagatgccgc 2249941 aatcataatc agtgcacaag ctgtgactat cattcttccc cgaacttcat ccaattgccg 2250001 attttgccta gagctgatta agcgctcgct cacagacata ttttctctat tgtttatcat 2250061 tgttttacac tcctatgaat gtgttaagag gagaaacggt tgtccccgca ctcctctttt 2250121 tattaagatc agctttgctt cccgttggca tcacgtgtca ctttcatatc agtaaccgga 2250181 atgtagcctt ggtcagtaac aatgcttttt tgaatgtctt cactctttag ataatcaaga 2250241 aattctttag ctaaacctgt cgcttcacct tttgtataag aatgttgata agcccagatc 2250301 ggatactcgc cagttgctac atttttcgct tcaggtttaa caccgtcaat agatagagca 2250361 gttactttgt catctgttaa atatgagaat gcaagatatc caatcgctcc cggagtatca 2250421 gcaatgatct ttttcaccgt gttggaggaa tcttcagtaa tgccttctgc aggctccgct 2250481 ccgtcaagcg catatttcac aaatgtagca cgtgtgccgg aagaatcagg gcggtttaca 2250541 agtgtaatct tttggtcttt gccgccgagc tctttccagt ttttgatttt gccagtgaag 2250601 atttttttca attcatcttt tgaaatatcc tttacaccag catcagggtt tacagctgct 2250661 gccataccaa ctacagcgac ttgatgatcg acaagcgctt ttgcatcgat gccttctttt 2250721 tcttcagcaa aaacgtctga attcccgatc tgaacagctc cttcagagac ttgagaaagc 2250781 cctgttccag aaccgccagc ttgtacctgt atatcagcat cagggttttc ttccataaat 2250841 ttttccgcgg ctgcaagtac tagtggctgc attgccgatg aaccagaaat ggttaaagaa 2250901 cctgatgcct tttcttctcc ttttgcagaa tcgctattcg attttttact ttctcctgca 2250961 tttccgcatg cagctgcaat catcataaaa gcagccatca gaagcataag caccaatttg 2251021 ttttttttca tttcctgaat tccccctgcg tataatgtgt aatttgtcct acacgtatag 2251081 agtaaaggtt ctatgtaaaa agggtttgaa ccgaatgtta aggttttgta aatcagtgcg 2251141 tttttttgta taaaaaaaac gcccacatca tgtgagcgtt tttttttagt tatcagaaga 2251201 cgttgtgttt tctgcatttt cttcaatttt gtctttattc ttttgctgag taccttcttt 2251261 gtcctgcttc gatttcagct caaaatattt atccattact tccctgccga tttcgtttgt 2251321 aattgagtat ctttgattgt aatcaatgta agtccaagga actacgacag aaatagcaat 2251381 ctcaggattg tcagctggtg cataagccac aagcgtcgta ttataagtgt ctgttcctgt 2251441 ttttgattta tccggtccgt cgtaaaatga ttgggctgtt cctgtttttg cagctggttt 2251501 atacgatgct gaagccagtt gacctgcagc tgtcccttta gtggcaaccc gtctaaaacc 2251561 ggcttggacc tcttcaatat agctactctt catatcgact ttattcaata cttcaggctg 2251621 aacagaatca acgactgcgc cgatcccttt tttcgcattt gaatctctga cttcctttac 2251681 aagctgaggc ttcatgcggt agccaccatt tgctatggtg gagacatatt gagccaattc 2251741 cagcggtgta taagtatcat actgtccaat ggcgaaatca agcaagaaac cagataatct 2251801 gcttgtacct ttatatcccg tcatttcatt tggtagatca attcctgttt ttactcctaa 2251861 tccaaattga ctgaaataat ttctgaaggt atcaaatgca gaagtatcca aaggcaatgc 2251921 ttggtgaggt ttatattcac ctttaccaac tgcaattgct gttttaaaca taaaaacgtt 2251981 tgatgacttc tctaatgcag tttgaatacc aaccggccct aagttttgcc aagatttttt 2252041 ccctctttta tcctggccga tatacaatgg ttcatcctta aatacagtat tcaaattaat 2252101 cgctccagtt tgaagaccgg tcaaaacggt tgcacctttt acagctgatc ccatagcgta 2252161 ggatgaagtc atggctccta atgcataatc atcaaactta taggctccat tttctcgttt 2252221 aatctgcttc cctgccattg tcagcacttc gccgtttcta gggtccatca tgacaacgaa 2252281 tgcacgatcc aacaattcgg tactaggtct tgctttagca gctttaagtt ttttctcaat 2252341 aattttttcc actgattttt gcaaatcaat atcaattgtt agtacaagat ctttcccggc 2252401 tttgccttca gataccgttt ttgttcccgt gacattgcct tttgaatctg tgatattttc 2252461 gacttttgct ttttggccct gcagaaggct ttcatattgg tattccagat agctttttcc 2252521 gaccctgtca tttcggctgt agccaagcga cagataatgg tcgagcaagt tggacggcaa 2252581 tccttcatta gagctggaaa cacttccgag cactgagcga agaaggtttt tataaggata 2252641 ttcacgttcc caatcggacg tgacatcaac acctggcagt tcgtctaaat gttcacttac 2252701 cactgccatt tccttcgctg atacatcttc gtttttgata tattgagggg tcaatgcata 2252761 gcccgaatcc atctgtcttt tgatagcaag gatctgcata tctttatccg tcaattcatt 2252821 cagctgctta tcagtaatcc gttttagctg aagctggtat aaatcgtcat cggatatttt 2252881 tttgtcttca acctgctgtc tttctttaga gctaatgagc tttttcgctt ctttcggtct 2252941 agtcaaaatc caataatctt ttttatcccg ttctgttact ttttttgtat cgactttgat 2253001 catgtcagac agcttttttg cgatctttaa gcgctgttct tgcgtggtcg atttagatct 2253061 cgtgtatgtg attgcattta aagccttatt tgtcacaatg gcattaaagt ttcgatcata 2253121 aattttcccg cgtggtaccg ctgagctgac ttcactttgt tcctgcttat tcgcttggtt 2253181 tttgtaatca tcaccttgca cgatctgctt gatgcccagt tccacaataa tccaggtaaa 2253241 tataacaaag gcagctaaaa ataaaatatt cagccggatc ggaagcgact tctttttctc 2253301 tttatgattt tgcttttttg gtttatttct cctcataaca tcaccttttc tatttacaga 2253361 aagaaaagac actcaagtaa gagtgccagt tttcatttta aaggtttttt cgactttttt 2253421 ctacagataa cccctttttg gcaaaaaaat tatctctcgc cttttaaaag ggtcggttct 2253481 gttacccgtt tttggccgtc ttcttccatg gtttcatttt ccccttcttt ctccttaaaa 2253541 cgaatatcct tgacaaagta ataaatcaaa ggatgtccta tacccaatat cgcaagtgac 2253601 aaaggaattc ccacatcctc tttcagaagg gccacaatca ggagaaagca caaaatggaa 2253661 acaattctgc cggcgttcaa gaacatttct ctaagcacga tatattcaat tcttgctttt 2253721 ctggcatgcc tcgcgcgccc tatcacatca tatgtaagtg atacatatgg cacaagcaac 2253781 agaggatagc cgatggcaat aaaaacgccg tacgttaata atgtcgaaaa gctcatatgg 2253841 aacagaatca aaaacagcgc gccatacaaa ataagtccgc ccagcaaaat cgattttttt 2253901 ctcgcctttt tcttaatcag cctggatgca aagtagtagg caaagaagga aacagctgaa 2253961 ttgacaagac cgaatgtacc gagagcaagc tcgctgtttg tctcaataaa tacaaacaca 2254021 ctgattaaaa agacaaaaat cccttctctc aaaccctgaa aaaaatgcgc attcgtgatt 2254081 ctccgccaat tcatattgct atggcgctct ccaaatactt tgctcagcat aaaacggccc 2254141 tttgattctc tccgttttaa gaaaaagctc atcacgacag ccagggcaaa taaactgagg 2254201 gagagactga aaatcactgt ataacccgta ttattttcaa gccttgagat cacgaatccg 2254261 gctacaatcg ggccgatcat tcctgcagag gaagacagaa tgcccataaa cccgttgaaa 2254321 aagtctcgtg tatccggctc tgttatttca aaggtcagca cgttaaacgc tagccaataa 2254381 aagccatagc caactccgag caccgcgccg attagcacga ggcggctggc cgccgtttct 2254441 ccggctaaaa gcacacttaa ataaaaggca gctaaaaaaa tgacgccgaa ccttaaaatg 2254501 aataccctgt ctattttttt ggctaaccgt ccagccaaat aaaaggttat cggctgcatt 2254561 gtcacaatgg ataaattata tatcgccaaa tcaataaatt tccctgactg cttccaaaga 2254621 tacacattaa caaatgtatt ggacagtgca attcccagcg agtaaagccc gccaatggtc 2254681 agcagaaaga gtaagccttt gtttacgtct acatcgccta tcactttttt tagtttgctc 2254741 attactgact cccctttact atcccttagt ctgtctcact caaaccgaga tatgtaaaaa 2254801 gaagacataa aaaaacaagg tcccataatg aggaccttgt ttgtgccatt attttgcttc 2254861 gctgtataga cgagccactt cgtcccagtt tacaacattc cagaaagctg aaatgtaatc 2254921 aggacggcgg ttttgatagt taaggtagta agcatgctcc caaacgtcaa gacctaagat 2254981 aggcgttttg ccttctgaaa gcggagaatc ttggtttggc gtgcttgtga tttcaagttt 2255041 accgttgttc acaacaagcc atgcccagcc agaaccgaag cgtccagctg ctgctgctgc 2255101 gaattgctct ttgaatttgt caaagcttcc aaatacactg ttaatctctt cagcaagcgc 2255161 gccagtcggt tcgcctccgc cgtttggaga taaaagtgtc cagaataatt tgtggttcgc 2255221 gtgtccgccg ccgttgttgc ggactgcagt gcggatgttt tcaggaacag aatcaagatc 2255281 tgcaacaagc tcttcaactg atttgttggc aagagcagtg tttccttcaa ccgctttgtt 2255341 taaatttgtc acgtatgtgt tgtggtgttt cgtatggtga atagtcatag tttccttgtc 2255401 gatatgcggt tctaaagcat cgtacgcata aggtaattct ggaagttcgt aagccatgat 2255461 aattcctcct tagtatatat gtactgaaat gccgcttcac agcgagcctt tcttcattca 2255521 atgtaacaaa agaatgcttt gtaatcaatg aaaaagctca cgatttggct catttcagcg 2255581 gacatatttc actttaaccg ataatctgcc ccattaaacc tgccgccagc atttcttata 2255641 ggaccgtcca taaaaagtaa ccgatcatca aaagctgtat gatgcccttt gcaataaccc 2255701 ctgttaaaaa accaatgagt gagccgaggc caattttaaa cgctgacttt aagtccttct 2255761 gatggacgat aagttctgcg caaacagccc cgataaacgg ccccaatatg atccctgcaa 2255821 ccggaatgac aaaaggcccg attaataaac cgatcgtgct tccccatatg gcagctttgc 2255881 ttcctccgaa cctttttact ccaagcagat tcgacacgta atctgctgcg aataatactg 2255941 cggcaaaaac tgcctcaaca agccagaaca tataagaata cggactgaat gaaaataaaa 2256001 atccgtacaa tacaaatccg gcaacaataa atactacgct aggaataaca ggatacacca 2256061 gcccgataaa ggcaatgata aaaaccgctg caatcaacag ccaatacaac atatccatag 2256121 cttccatcct cccattttac tctgtcttct tcatgtcttc cttgtattca cacgcatgca 2256181 acgatacaat aagcaacata tattagttta gctaggaagt gaagatagtg aatgtgtttc 2256241 agcttttcat taaaagtaca tactctcccc gtgatattgc aaaaacaaga tttcaaggaa 2256301 tcggaaaagc gattctttat gtatttttgc tctctgtcct gtttgcaatc cctaccgctt 2256361 attatgtaag tacagggacc gtaaaatcaa tgaacggctt taaaactgtt ttaaacaaag 2256421 atttccctga tttcacaatt tcaaacggca aacttcaaac ggatgagaaa aaagccacgg 2256481 aatctcaggc aaatggtttc gttatcgtgt tcgatccgac agactcctat ggcactgaac 2256541 aaattgaagc aaagcaaaac gcaatcggca tccttcagaa caaatttgtt ttggccattg 2256601 acggacaagc ccaagaaatg tcttactcaa tgatgccgtc agagttacag aaaaaagatg 2256661 tcattgcagg tttaaaccaa aataaagcga tgattgtaac tgttctctca gctcttattt 2256721 ttctcgtaac agcagcggga aaatttattg aagtatcgtt tttagcgctt atcgggttaa 2256781 tcattaagaa ttcgcagaaa aaacatttat cctatcatca gctctggaag ctttctgctt 2256841 attccatcac actttcaact gtattcttta caatcatgcg ggcactagaa gcaaccgtac 2256901 caagtgaatt tttgctgaac tggtttgtca attttgtcat cctgtttctc gttttaaaag 2256961 agattccgtc caaaaaagta attaataaaa gttaaattat atttattttt atcctttaag 2257021 tagagagtgt gaaagcattt gcattaactt tttacttaag ggatatttaa taaaatgtat 2257081 agagcttaaa cagatacatt tataaaaaaa gctctacaat tactcaagaa caagctctgg 2257141 acaataatat cagaagtagt aagatgtaac atgaaagaag ttcttaacag catttgacat 2257201 atgtttttaa caaaataaga ataatgttaa attttaacta atagactagt taaaatcata 2257261 tggcaaaata ttttgcatcc tttcacaaca tatttacata agatagttgc tatttaaaaa 2257321 gccaggtacc aatagggcac ctagctttca gaattaaatc atcaacaagt tagaattatc 2257381 ttctttcctt ctattctcat tattgaactg ttatcttttt tgtgggttta tgtatacaaa 2257441 tgcagctccc ttagctttcc ccttatatac tgataaacct actgcccaag gtgttcctgt 2257501 cggttttggt aatttactga agtaaaactt tttggttgga gttctacttg aaaagtaccc 2257561 tgaatattgc gggccaatgt ccccaccctc aactatagat acaccaaagc tcttataatt 2257621 tagtttaccg cattttccat ttgtttcggc gtaagcatca atagatgttg cactcttagt 2257681 atatgtataa gcatctgtaa taactcttat tttacaacca gaaataccac ttaccggttg 2257741 ccaaccactg cttgcagcct ctgctttttc tttaggtgca actaccaaag ttaacattag 2257801 tagcaaaatt aaaaacacag aaaattttcc ttgcttcatt ttgtagatcc tcctttaaac 2257861 tattacataa ttatcctaac agatccattg ttcattgtaa ataatggaat acgagtttta 2257921 tattataaaa gcctcttttt gatctaattt tgcactattt tctattttct atctgaagtt 2257981 aatgtttagt cgaagaaatc ctgtcaaaaa agcgcctgta taaaaaccga gcattcgcag 2258041 tctcttttct tttgtcatga atcgaaatgg acaagcatac tatggtataa aatttcgtat 2258101 gcgggaggaa aagcgatgaa gcgtctcacc ttagtatgca gcattgtttt tatacttttt 2258161 attctttttt atgaccttaa aattggaacc atacccattc aggacctccc tgtctatgaa 2258221 gcatcagcaa aaacggctgt acaagaaccg gcttataaaa cggtgaaggt aaagccgggt 2258281 gatacggtta tgtcgatagt cggatcagca ggttctccgg atgacattgt aaaggatttt 2258341 gaagcactga atccaaatgt gaaagctaac gccattcaag ccggaacagc gtataaattc 2258401 ccggtctacc cttaatttaa cgttaatttc ttgtcagttc ggcgaagaca ctgttacaat 2258461 gtaatttgta aaataaattc acataaacca tactagaatt gttatatcta gaagcggcaa 2258521 ctacaattaa ggagcgattg caagtgagtg aaatcacaca tcgtacaaaa acgcgtcccg 2258581 tcaaagtggg acctttaaca ataggcggca acaatgaagt tgtcatccaa agcatgacaa 2258641 caacaaaaac acatgatgta gaagcaacgg ttgcggaaat taaccgtttg gctgaagccg 2258701 gatgccaaat cgttcgggta gcatgtccgg atgaacgggc ggcaaacgcc attgcggata 2258761 ttaaaaagcg catttccatt cctctcgttg ttgacataca tttcgattat aaacttgcgt 2258821 tgaaagccat tgaaggcggc gcagataaaa tccgaatcaa ccccggcaat atcggccggc 2258881 gcgaaaaagt tgaagcggtt gttaaagcgg ccaaagacaa aggcattccg atcagaatcg 2258941 gagtaaacgc cggttcattg gaaaaacgga ttttagaaaa atacggttat ccgactgccg 2259001 atggaatggt agaaagcgca cttcatcaca ttaaaattct tgaggatctt gattttcacg 2259061 atattattgt cagcatgaag gcctctgacg tgaaccttgc aatcgaggct tatgaaaaag 2259121 cagcgaaagc gtttgactac ccgcttcacc tcgggatcac cgagtcagga acactgtttg 2259181 ccggcacagt aaagagcgca gcaggactcg gcgccatttt aagcaaaggc atcgggaaca 2259241 ccatgcgcat ttcactaagc gcagaccctg tagaagaggt aaaagtagca agggagcttc 2259301 tgaaatcttt cggcttagcc tccaatgctg ccacgctcat ctcatgcccg acttgcggcc 2259361 gtattgagat tgatctaatc agcattgcca atgaagtgga agagtatatt tctaagataa 2259421 aagcgccgat taaagttgct gttctcggct gcgctgtaaa cggacctggt gaagcgagag 2259481 aagctgatat cggaatcgcc ggcgcacgcg gtgaagggct gctgttccgg aaagggaaaa 2259541 ttgtccgtaa ggttccagag gaaacgatgg tagaagaact caaaaaagaa attgacattc 2259601 ttgctgagga acactacgca aaacttgaag ctgaaaaagc aaaattaaaa gaagaaacac 2259661 aaaaagcttg acgggaaccc gtcaagcttt tttgtgttag aaaaatggaa taataaatat 2259721 tccaagcact aatgaaacga caccgatacc cattgcccag gctccaaggc cttgagcacc 2259781 tcttcttctt gcgatatagc cgacaataat accagcagct cccaataaaa caggcagtac 2259841 aaacaatgaa atgatggaca aggctaaagc gatgtaccct attccccgtc cttcattgac 2259901 attgccgccg ctgcgatcat tgtcttggtc attgctgcgg tcagcagcac gataaggctc 2259961 tgcgatttca gcagctgttt cctcaaaaaa accgtcattg tcgcgggtaa tatttgtccc 2260021 ttcagatcca tgatcaacat agtaactgtt gttatcacgc ttttcgtaat cgtttgccac 2260081 cttcaattcc cccttctgtt ttattaaagg agcttttata gtttgatcca ttttgcctga 2260141 ttcatgtttg ctaaactttt ctgttaatgt caattgttta tgttacactt gaagggatga 2260201 aactgaagga gtgtgggcat gttacgctta ggaatagata ttgacggcac aatcacggct 2260261 caggatacat tcgtccctta tttgaaccgt tcgtttaatc tttccatttc attaaacgat 2260321 atgacggatt atgatttaac aaagctgtta aacattaccc aggaagaatt ttgggattgg 2260381 atgaatcaaa atgaagcgat catatataag gaagcattgc ttgcacagca tgcgaaacag 2260441 tctctcgatc ttctcaaaga ggagcacaag cttatttata ttacagcgag acggactcat 2260501 ttaactgata ttacttatga atggtttgac agacaaaaca ttcattatga ccacatcgaa 2260561 cttgttgggg gtcatcacaa agttgaagcg gtcaagaatc ataacatcga cctgtttttt 2260621 gaggatcatc acgggaacgc catgatgatt gcgaaagaag ccgggatacc ggtgattttg 2260681 ttcaattccc cttataatca gcttccgatt gattcaaaca tcatcagagt aaacaactgg 2260741 ctagaagccg ttcaatggat gaacaacaac aagcatcact taatacgcgt caataactga 2260801 aaaaggagcc caaaccgggc ccctttttca tatatacgca ttttacgcag tagtgttttc 2260861 ttggttttcc gctgtacaat cagggcatgt gccataaatc tcaaatttat gcccgctgac 2260921 ctgatagcca tccaaatcat cacaaagctt gtccatcgga catgattcaa tttcctttgt 2260981 tttgccgcag gcaagacaaa taaaatgatg gtggtgatgg gtgaatgaac acttaaatcg 2261041 gaagagcttt tcaccggaca gctcagttgt ttccaaaatc ccaagttctt catataaaga 2261101 aagatttctg tagattgtat caaagcttaa gcctggataa tcatcattca gtgcagacag 2261161 tacgttttta gcggtaagat atctgtctga atcagcaaaa agctgcagca tatcctcccg 2261221 tttgtttgta tatttatatc cgttttcttt taataggttc agcgcttctt ggacgttcat 2261281 gaagggtccc ccttttcgct ttgcttaaga acgtatcaca tgtatgaaaa agaaaatggc 2261341 agctgtctgt ccagcaagcc attttcttta ctgcagataa aattataccc ataaaatgaa 2261401 taaaagtaaa tgaaagccta gtggattgcg tttttgaatt ttccgcctct cgtttcatga 2261461 gtattcataa ttgttatgaa tgcattttga tcaacttcaa acacgatcga tttgagcttt 2261521 gtcacttcca gccttgtgac aaccgcgtaa attacgtctt tttcttcgtc cgtatacccg 2261581 cctttcccct tcagcttcgt tgtgccccga ccgagacggt gcaaaatcgc gtcggaaatc 2261641 tcatcatact gctcagacac aataatgaca gcttttgttt catcaagccc ttggatcacg 2261701 gcatcaatcg ttttcatcgc aatataataa gtcatgaatg agtacatcgc ttgctcagga 2261761 ccgaacacaa aaactgccca aatgaaaatg aacacattga tgaacataac gaactcacct 2261821 acagaaaacg ggagtttttt ggtcagcaaa ataccgagaa tttctgtacc atccattgaa 2261881 cctccatttc gaataacaag cccgacgcca aagccgagta aaagacctcc gaacacagta 2261941 gccaaaatag gctgggttgt aatggcttct acatggtgaa gtgaggattc aataacggca 2262001 agcccgacaa tccctataaa cgtagagact agaaaggtct taccgatata tttatatccg 2262061 aagatcataa aaggaatatt taatatgaca acgaaaaaag cgaaattcag aaaggggttt 2262121 gacataaaga ggtggtctaa aataagagat acaccgataa tcccgccatc aataaaatca 2262181 ttggggatta aaaataattc aatacttaca gccgcagatg cagctcctac cagaatcata 2262241 aagaccctga aaataaaatg ggtaaatgtt tctttcttat gttgttttgt tggggtcata 2262301 aaatctcctt tcctgcaata actattttaa atacattata aatctatttt accattaaac 2262361 actgacacat tttactgatt tgcccataca ttaagtctgg aggtggaatg accgatgatt 2262421 ttatttcaaa gaattatttt gcagcggctt aatcaggcta ctgctgatga tttgctgaag 2262481 tactcaaaac aatacggaat cagcttaaca agatcgcagg ccgttgaagt agcgaacctg 2262541 ttatacggga aaaatgtaaa catctttaat gagagtgaac gaatgcggct gctgaaacaa 2262601 gtagagacga ttacatcgaa agaaacagct caaacagtta atgaactatt caaacaattt 2262661 acaagctaaa aaatgggggt gttatccccc attttttatt gctgtaaaat cttttcaagc 2262721 aatgtatcat caaattgttt ttctttcagc atttcaatct caaaacggta tggcggtttt 2262781 ttgttctttt tatcttcacc gacgtatggt gtttcaagaa tttttggaat gtcttttaac 2262841 tgctcatggt gaacaacata ttgcagtgcg tcaaaaccta tttcaccaaa gccaatattt 2262901 tcatggcggt cttttctcgc acctttgaca tttttgctgt cattgatatg aagcacttta 2262961 atacggtcaa tgccaatgat tttatcgaac tcatttagca ctccgtcaaa gtcttcgaca 2263021 atgttatacc cggcatcatg tgtatggcac gtgtcaaagc acactgacag ctgctcattg 2263081 tgtgtaacgc cttcgataat ctgcgcaagc tcctcaaagc ttctgccgca ttctgatcct 2263141 tttccagcca ttgtttctaa tgcaatctgg acattttgat tcggatcaat cacttcattt 2263201 aagccttcaa taattttttt gatgccggct tcagctcctg cccctacgtg agcgccagga 2263261 tgaaggacaa tttgcttcgc tccgatggcc gctgtccgtt caatttctga acgaagaaaa 2263321 tcaacaccca gctcaaaagt ggacggattt gtcgtgttgc caatattaat aatataaggc 2263381 gcgtgtacga taatctcgtc aatgccgttt tcttgcatat gtgcccggcc tgcttctata 2263441 tttaagtctt caattttctt tcggcgcgta ttttgcggtg cgcctgtata gatcataaac 2263501 gtattcgccc cataagagac tgcttcctgg cttgcagcca gaagcatatg ttttccgctc 2263561 atagagacgt gtgagcctat tctcagcaac aggttcccct actttctttt cttagattgg 2263621 tttcttctct gttttttctt gattttctcc atctcatagc tcattttctt tttataccca 2263681 ggcttaacct tcttcggctt tttcacgaga cgatgagcaa tttcatccgc ttcattcggc 2263741 gtttttttac gttttttgcg gcgctgacgg tcatcgcctt ttttccattc gcccttttca 2263801 agctctaagt actcaaattc gatgcccatt ttttcaagtc ttactaatgc atcctcatca 2263861 gtaagctcat aaatggtcat cgcttgtcct gatgagccgg cacgagccgt tctgcccaca 2263921 cggtgaacat agaaatcgag atcatccggc agctcatagt tgataacatg gctgacacct 2263981 ttaatatcaa tacctcttgc ggcaaggtca gttgcaatga tatatgtgaa ttccaaatca 2264041 ttgatctgct tcatgacttt tttccgctca cgtggtgtta atccgccgtg cagcaagccg 2264101 attttcatgc ctttgccagt cagatactgg gcaatatggt cagccgtatt tttcgtgttg 2264161 gcaaacacaa tccccaggta tggattcaga tgcgacatga tgtcaaaaag gagcttgtcc 2264221 ttgtcacgat gtttcgaagg aatgaggata tgctcgattt tcgcagcagt cacctgtttt 2264281 ggctccacat gggcgtattt cggattttcc atgtatttct tcaagaatgg tttcagcttt 2264341 tccggtatgg tcgctgagaa cacaagcatt tgcagatcct caggcatgcg ggaaccgatg 2264401 taatctacat ctgcaaggaa tcccatgtcc agcattaaat ccgcttcatc aataacaaga 2264461 gattccgctt tatgaacact taacgcctgt tctttgatta agtcagcaat ccgtccaggt 2264521 gtaccgacaa caagatgcgg ctgtattttc aatttatcaa ttgatttttg tttatcagtg 2264581 cctccgataa aacatttcga gcgaatctga cttccttctt caccctgcgt gattttaagc 2264641 gcttcctgat aaatctggtt ggcaagctct cttgtcggag ccgtaatgac tacctgaacg 2264701 acatccttag caggatcgat tttgtttaat aaaggcagta aataagcgtg agtctttcca 2264761 gtacccgtct gagactggcc gatgacgctt tcttttttta acactgcagg aatcagcctt 2264821 ttctggatat cagtcggttc gtaaaaacca aggcgatgta ctgcatctat aataaatggt 2264881 ttcaattcat aaagttcaaa tttcgtttct ttcatttttc ccagctcctt aaagcggcac 2264941 attatgtgtc catcatcaca ttatacccga ttttgcttaa aaacaccacg tttgcaaggc 2265001 gtttgtttta ttcagttatg taaagcaaat accgcagccc atgcatattc taatagcaga 2265061 gagagctgaa aggaggtaca agtatgtttt caccgcagca gccaatgaga aattacccac 2265121 agcccggacc gccccgcccc atgccaaatc agcgaatgat gggcagaaga ccgcctaata 2265181 tgcgaggacc ttcatttgga gcacagcagc aaggttttca gcaagccgga caatttcttc 2265241 ctcaggcaaa tgccggagcg agaaatggtg caggtgcagg cggaggctta aaaggaatgc 2265301 tgtcaaggtt cctccccggc ggaggaggcg ctggcagcgc cggggttccc ggaattccag 2265361 gagcaggtgc agcagcgagc ggaggtgctg gcctgcaagg cattcaaaat attgccaatc 2265421 ctgcatcatt atccagtatg cttggaaatg tgcaaaaagt actcggcatg gcgcagcaag 2265481 tcacccctat gatccagcag tacggcccat tagtccgcaa tctgccagca atgatgaagc 2265541 tgtacagcca attaagtaaa agtgatgata ctgagacaga ggccaatgag gaaagtgaaa 2265601 aacaatccgt ttcagaagaa tcatcagaaa aagaaaaaga gactgaaaca aaaacctcag 2265661 atgggaacaa aaaatcaaaa ccaaaaagtt cttctctccc aaagaaatct aaaacaactg 2265721 acaataaaga acaagaatta aaaacatctg ccccgaagaa aaaggaagct gcctctcctg 2265781 ctccgaaaag aacatcaggc agttcaaaac cgagattata tatttaacat tctttgatat 2265841 cttaagtgag attggctata atgagatcag aagaatgcaa gaatagagcc gtttgattac 2265901 ggctttttat attgccttta ctcacttcag tattggagga caaccgaaaa tggacgtaat 2265961 taaaatttca ccgcgcggct attgctatgg tgttgttgat gctatggtca ttgccaaaaa 2266021 tgcgtcgcta gataaaagct tgccaagacc catctatata ctcgggatga ttgttcataa 2266081 taaacacgtc actgatgcgt ttgaagagga agggattttt acattggacg gctctaaccg 2266141 tctggacatc ttaaagcagg ttgacaaagg aactgtcatt ttcactgcgc acggtgtttc 2266201 tcccgaagtc agaagaatcg cagaagaaaa agggttagtc gcaattgatg ctacatgtcc 2266261 ggatgtgaca aaaactcata atctaatctt agagatgaaa gaaaaaggat atcacgtgat 2266321 ctatatcggc aaaaaagggc atccagagcc tgagggagcc gttggcgtag cgccggagat 2266381 cgttcactta gttgaaacag aagaagatgt aaagaacctt gatatccaat ctgagaagtt 2266441 aatcgtgacg aatcaaacaa caatgtctca atgggatgtt cacgacatta tggagcttgt 2266501 caaagaaaaa tatcctcatg tcgaatatca ccaagagatt tgcctcgcta ctcaagtgcg 2266561 gcaggaagct gtatcagagc aggcaaaaaa agcggactta acaatcgttg tcggagaccc 2266621 gaaaagcaac aattcaaata ggcttgctca agtgtcagag gaaatagccg ggacaaaagc 2266681 ataccggatc ggcgacttaa gcgaattgaa gctcgaatgg ctgaaaggcg ttaataccgt 2266741 tgcagttaca gcgggagctt caacaccgac gccgatcaca aaagaagtca ttcgcttttt 2266801 agagcagttt gatcacgaag atccatcaac ttggacaact gaacataata taccgctcaa 2266861 aaaaatactt ccaaaagtaa aagcaaaaaa ctgaggctgt aaaagcctca gtttttttat 2266921 agaaatgtaa atggatttgt atctgtttca gaaacaaaga tattcacgcc aaacttttta 2266981 tcattacaca ttgatgtaag ttttctcgtg acgccttctt tcatgatttt ttccgcgtaa 2267041 tggcccggat caaccacatt taggccaagc atcatcgcat catgggccac atggaagtat 2267101 aaatctcctg tgacgtaaac atcggctccc tttcgttttg catgatgaat atacttgttt 2267161 ccatctccgc caagaacagc tacttttttc accatgctgt cagcatcccc aaccattctg 2267221 acaccattga cgtcaagctt gtctttcaca aataaagcga attccttgag cgtcatctca 2267281 tttttaaggg ttccgacacg gccgagccct ttttcggcgg gagtctgttc gacaggatag 2267341 atatcgtaag cgacttcttc atatggatgg ctttttatca ttgcattgat aacagccttt 2267401 tcgacgcttt taggaaatac agtctcaagc cttacttcat gaacaagctc aagctctccc 2267461 acttcaccga taaaaggctt agctccgtcc aatggcttaa agctgccgat tccttcagat 2267521 gaaaacgcgc aatggctgta ttcaccgata tggccggccc ccgcatttcc gagcgcggct 2267581 ctgacctgct cttcatattc cttcggcacg taaactgcca gctttttcag aggatccgta 2267641 taagtaggtg ccagcacttc cgtctcactc agctctaatg cttcagcaag caaatcattc 2267701 acaccgccgt ccgcaacgtc taaatttgta tgagctgcat aaacagcaat atcatgcttc 2267761 aaacactttt caattaacct tccggcaggc tgatctgttg aaatatgctt tagcgaccgg 2267821 aaaattggtg gatggtgtgc aataatcaag tcaacctctt tttcaatcgc ttcatcgata 2267881 acgctctcta acacatcaag tgtaaccatc acatttttaa ttggtttgtt taaggtgccg 2267941 atttgcaggc cgattttatc tccttcaacc gcataggctt tcggggaaaa ttgttcaaac 2268001 agctggatga tctgctgccc atttacactt ttagccatga tcgattacct cctttaacag 2268061 ctccattcga tcggcgagct cctttaattt ttgtttgttt tgctctgtat ccgccgcttg 2268121 gctgatctgt tcataaatgc tttgagtgtg ctgaagctct tgtgtccact ttttcaaaaa 2268181 gacagcattt ttttcttttg ccaagaaagg gccaacgagc atcccggctg ataaagaaat 2268241 accgtcataa gccgcatccc tgtctcccgc ttctgccacc agcacctcat agcactttcc 2268301 gtcctcttca aggattacct catctatcag cgcatatctt tctttataaa gccactccct 2268361 gatatgaaca gcatgaatat tcggctgtaa aatgagccgt tccttccccg ttaatttgtc 2268421 tttgcccgct tctaaaatgt gagcgatcaa agccccgccc attccggcaa tcgtaatggc 2268481 atcagcttca ccttttttaa tcacttccag tccgtctccc tgccttacag aaatgtgcga 2268541 gtttaagcct gatttttcaa cctgccgctt tgcagacaaa aatgggccgt ctgttatttc 2268601 tccggcaatc gccccgctgg ctttatgatt cagcaccgca taacaaggaa ggtaggcgtg 2268661 gtcagagccg atatcggcca tcaccgctcc attcggtatg tactccgcta ctgtttgcaa 2268721 tcgtttagat aattttaatt cgttcacttg tcatcacaac ttttctcaat cattttttcc 2268781 tttactatca tataaaaaat cagcccggaa tccaagctga agcaaatgat tttgaaatta 2268841 tttcttttga tgcgggtctg cacgcagcag tcaaaaataa aaggctgtcg agaacatctc 2268901 ggcggcctgt gaatgtataa agagaaaaat agttctttta tttaattttt gacacccact 2268961 ctgccatatc atccagctta tcggccggaa caagaccgga aggcattcca ttaccgcctt 2269021 tttcgatctt tgttttaatt tcagcgacat ctttcttatc ccctacacct tttaagctag 2269081 gacccgaaac accttcataa ttttcaccgt ggcatgcgat gcagtttgcc ttgtaaattt 2269141 cttctggtga agcgtttgca tctttctttt cagcagattt gctttctcct ccgctcgcaa 2269201 tctcccgaga gtcatcaagt ccttttactg ataaaaagaa agttagacca attcctaaaa 2269261 cagcgatcag caaaaatgga ataagcgggt tccatttcat ttcccttccc cctttttgat 2269321 ccttccccct atgtaaacac ttctaattct aacttatttt tacaaaaagt aaatggattg 2269381 ctatacaaaa gttttttatt cacactttat acaaaattga atagaaacat gcctaaatct 2269441 ctaatatcct ttttattcta ttgtataatg tattgtatac gcttacaata gaaaatatgg 2269501 aattagattt tgaaattttt caccacaatg ttcatttgca aatgacatca tttttcagta 2269561 aaataaaggc atattatcca tatatctttt taaaaaaaga agaacggatc ttcaagaccc 2269621 gttccatctt attcaaggaa atctttcaaa cgtttacttc tgctaggatg tcttagtttc 2269681 cgcaacgctt tggcttcgat ttgtcgaata cgctctctcg ttactccaaa tactttgccg 2269741 acctcttcta atgttcttgt acggccgtca tcaagaccga atcgaagacg caatacattt 2269801 tcttcacgat cagttaacgt atcaagcaca tcttccagct gctctttcaa tagctcgtat 2269861 gcggcgtggt cagaaggtga agttgcttct tggtcttcaa tgaaatcacc aaggtgcgag 2269921 tcatcctctt caccgatcgg tgtttccaga gataccggct cttgagcaat ctttaagatt 2269981 tcgcgtactt tttcaggcgt taaatccata tcttccgcaa tttcttcagg tgttggttct 2270041 ctgcctaagt cttgcagtaa ttgacgctgc acacggatta atttattaat ggtttcaacc 2270101 atatgaacgg gaatccggat cgttctcgcc tgatcggcaa tggcgcgtgt aatcgcctgt 2270161 ctgatccacc acgtagcata cgtactgaat ttataacctt tgcgataatc aaatttttca 2270221 acggctttca tcaggcccat gtttccttcc tggatcagat caaggaacag cataccgcgt 2270281 ccgacatacc gttttgcgat actgacaaca agccgcaggt tcgcttcagc caatctgcgt 2270341 ttagattctt cgtcaccttc ttcaatcttt tgagcgtagg cgatttcttc ttttgcagaa 2270401 agaaggttaa cccgaccgat ttcctttaaa tacatacgaa ctgggtcatt gattttaacg 2270461 ccaggcggta cacttaggtc attaaggtca aattcttctt cggctttggc aagctgctga 2270521 atattaggat cttctgtttc ttcattctca ctaattaatt caacaccttg ttcacctaaa 2270581 aattcataat actcatccat ttggtctgat tcaatttcaa agctggacat acgctcagca 2270641 atttcttcat atgtcaaaac gccacgtttt ttaccagact ctgttaattg ctcttttact 2270701 tggtcgaatg ttaattctgt ctcgtgggtt tgtttatcag ccattatgga tccctccttc 2270761 caaagcttgc aacgaattct ataagcggta tgattcttat tcggtccatt caggcgtttt 2270821 ctatgtgaac tgcctttaac aatgtgcgaa taatgaaatg acaattcatg atgaggttaa 2270881 gcgatctatt tgctcctccg caaggaatca ttgccaataa atgctcctca tcagttctcc 2270941 agttatttta aagatcggtt caatgtaacg atttcttgag ccaaagaagc agctcttaaa 2271001 aaatcttttt gcctttctgc ttcggctctt tccgcctctt tttcttttat cattgaccaa 2271061 tttctttgat tcaacacttt ttttacataa tctgataact cggcttcgct aagctcttga 2271121 ttaacctgaa gcattaatat atcggacaag agctggctta tatgatcatc cgtcaccctg 2271181 gccatcagat gctgaggcgt cagctcggct ccctcttcat aaaaagcata aagataagcg 2271241 gctaatgccc ggtgctcatc aatattaaat tgaaacccta cccggtcaat cacttttttg 2271301 atgacgctcc gatctcgaag catgtgagcg agtaacagcc tttctgcatt ttcatacgcc 2271361 ggacgcaaac gtttttgcct tgcttttgtc gtcagatgcg ctcgccgcgt tttagtttca 2271421 ccgctattgt cagcaggttt gttttgcttg ctgaaaacag acagctgctc agttaaagac 2271481 tcctgtgaaa gcgaaaactc tgaagcaagc tgctttacat agacttcctg ctctagagac 2271541 cctgaaagcg tgctgatttc tttcagtacg tctttaatgt aagctaggcg gtcgccttca 2271601 tcggacaggt tctttccttt tcggaaatat tgcattttga acgccattac ggtgacactt 2271661 gcgtcaataa tgtcgttttt aaatttttcc ccgccgaatt ttttgatgta atcatcaggg 2271721 tccaatccgt caggaatcat tgcaactctg actttgcagc cttttttttg cagaagctcc 2271781 gaagctttta aggtggcttc ataaccggct ttatcagagt catagcaaag aatgatttct 2271841 tcgacgtttc ttctcaggat cttgacatga tcatctgtaa gagacgttcc catcgtggct 2271901 atgctttcct ttacatccga gcttacggcc gatatgacat cagcaaaccc ttcaaataag 2271961 actgctcttt cctgctttct gatatgaagg cgggccttat aaaaattgta aagcagtttg 2272021 cttttatgaa agagcggggt ttcaggactg ttcatatact taggctgctg gctgccaaga 2272081 gccctgcctg agaaagcaac aacagccccg tgatgatcat ggatcggaaa catgacacgg 2272141 tttctgaagc ggtcgaaata tccgcttccg tcttcgcgtc tgatcaggag acccgctttt 2272201 tccatttgcg cctcactaaa tcccctcttt acaaggaatt tcgtgataaa gtcccaagaa 2272261 tcaagagcat agccaatctg aaattcatta atcagctctt tcgtaaagcc cctagaaagc 2272321 agataatcca gtgcctcttg accttctttt gtatttatta acaaatgatg gtaaaatttc 2272381 ttcaggagct catgtgcctc agccattttt tgttctccag aagactctgg ccgggctccg 2272441 gaatggactg ttatatcatc tggaaaatca atttggtatt tgtcagcaag gtgagaaacc 2272501 gactcggcaa aagaatagcc ttccatctgc cttaaaaaag agaaaacatt gccgcccgct 2272561 ccgcagccaa agcaatgaaa aatctgtttg tcgggcgata cggaaaacga aggtgtgctt 2272621 tctccatgaa aaggacagag tccaaagtag tttcggcctt gcttctttaa ttgaacataa 2272681 tcacctatga cttcaacgat atctgccgac ttttgcacct gatccacaat ttcatctggt 2272741 atccgatttc ccatcttata acactccgtc gtacattatt cgatgcttta gtgcaaaatc 2272801 ccttcatcgt tcgacaggat tttttgcagc agtgtaataa atcgttctcg atcttcttta 2272861 ttcaattttt taggcccttt ggcatatacg ccttttcttc tttgtttgcc ggaaaaatga 2272921 cggccctcta gggcaaaatc aatcgtgtct tccttgtaaa gacgacctct ttccgacata 2272981 acagagacat ttctgttcaa cagcagagat gctaatccga tgtcctgcgt cacaacaata 2273041 tctcccggtt tcacgtgatt tgcgatatat aaatcagcag cttctttatg aggatcaaca 2273101 tacttccatt tttcttcatt gcttctggaa agctgataat gttcaaatga agcgacaaaa 2273161 agaacttgaa cttcatactc ggatgctgtt tgtaaaattt catcttttac cggacaagca 2273221 tcagcatcga caaaaatcgt cttttcttgt tcattaagaa gagtaattct ccatccctcc 2273281 attaaactcc tgcataaaag caagcaaaat cgcacatcct ttattattgt ggatgtatat 2273341 gaatttgtcg aaaaatttcc gggagaaatt cttgacatct tacccataat agtttattcg 2273401 tatcacacga tccttaaacc taaaattaat cattttatca caatttttta ttataataca 2273461 aacttcacaa agatgctatt gtttttcatt attccctttt ggcacagcca aaaacccagg 2273521 atagagcgtc ctgagttata tgttttttgt tttgagatga tggataatat ttgctgtttc 2273581 ctcaaccgct ttatttgaaa catcaacaac ctggcagccg atccgatcca caatcttttc 2273641 gaaatactcg agttcctctt tgattctgtt gatatttgca taaatcgctt tatcattaag 2273701 cccgagtgat tttaaacgtt cttttctgat atgattcagt ttatcagggc taatctttaa 2273761 accgatgcat tttttcggat caacgttaaa gagttcttcc ggcggatcaa cctccggtac 2273821 aatcggaaca ttggcaacct tcaggcgttt gtgtgcgaga tattgagaca gcggtgtttt 2273881 agacgttctt gacacgccga tcaaaacgat atcagctttt aaaatccctc ttggatcacg 2273941 tccatcatcg tatttaactg caaactcgat ggcctccact tttttgaaat aatcttcatc 2274001 aagctggcgc acccgccccg gttcgtattt cgctgttaaa ccgtaggctg tttccatttt 2274061 atcaatcaac gggccgataa tatcataata taaaacattt gctttttccg cttcggctat 2274121 caaatattct ctgatttccg gcaccacgag tgtaaaacag ataatgccgc cgtctgcctt 2274181 tgcaagtgaa atcacttcat tgatagtgcc tatatcttca acataaggaa ttcttcttac 2274241 atgagtatca tccgccgatc cgttaaattg gctgagtgct gcttttacta ccaattcagc 2274301 cgtttcaccg acggaatccg atacaacata gatgatgcgg ttattcatat tatccccccg 2274361 ttagtttgca atcttatagg atttcatttt cagataaact gacaagtatt ttggtcatat 2274421 ttgtttttgt cactctgccg atcacttcaa agcctttatc ggtgtctttg atgacaggca 2274481 gtgcatcaat ttgtttttct attaagtgct ttgcaatgtc catcacataa tcctcgcgtc 2274541 tgcacaccgt aatgttcggc atccttgtca tgatgatgtg aacagggacc gatgtaagct 2274601 cctgctggcc aatgctcgct ctgagcaagt cttttcgtga aagcaccccg actaaaacag 2274661 catcgcggtc caccacaaac agagtaccta catcttctaa aaacatggtg caaatcgcat 2274721 cgtacacaga aacgttttcg tgaatcacta cggggataga ttgaaagtct ttcacctgaa 2274781 gctttttgag tttatccgcc aaaagctgtg tgccggtttt tcccgtatag aaataaccga 2274841 ctctcgggcg cgcctcgagg aatcctgaca tggtgagtat ggctaaatcc gggcgcaatg 2274901 tcgccctggt taggttcagc ttttctgcaa tatgctcccc tgtaatcggc ccgttttctt 2274961 ttacaatctg caaaatatgt tcttgccgtt tatttagttc gatcgtactc accacctttt 2275021 cacttcatag ctatgtaaag aaataacaat ccatattata acgtaaatat cttgtaatca 2275081 aacaaaaaac ttataaatgg ggaaaagacg attaccgatc acacagcaac cgccttttct 2275141 ctctttattt tacaataagg gcattcatat tcgcaaagga cttgatctca tccgccaagc 2275201 ttaccatttg cgctaaacga tttgccttta atgactcatt atccgctata accattgtat 2275261 gatcgaagta agcatcgatc ggttctttta aggctgcaag tgaagcaagc gccgcctcat 2275321 aatctttttt gctgaagttt tcctgcagat tttgcttcgc tgtttggtag gcatcaaaca 2275381 gttttgcttc gtattcattt tcaaacagat caggctgaat gtctccgcgg actccttttt 2275441 tgctgataga gatcactcgg cctaacgctt cggctgtttc cttaaagcca ggtgcaccaa 2275501 gcttttgctc cagtacttgt gctttatgca gcgcagagta cggctcaagc tcagagcttt 2275561 ccagcacggc gtcaatgaca tcatgtctga tttgttcagc attcaagaca tatttcaagc 2275621 gctgagtgaa gaaatccagc agttcatttt ctttatcggt ttgaacgaaa gtaagcagct 2275681 cttcaaatga aattccccag ttgcggtcaa gaagaatcgc aacaataccg cttgcttggc 2275741 ggcgcagtcc gtaagggtcc tgggaaccgg tcggaattac gccgatagag aagaatgaag 2275801 cgattgtgtc aagcttatcc gccattgcta caacagctcc ggtgaaagta gaaggcgttt 2275861 ctccgcccgc tgatctaggc atataatgtt cattaactgc cgcagccaca gcttcatctt 2275921 cgccaagcat tctcgcatac ttttcgccca taattccttg aagttcaggg aattcatata 2275981 tcatatgcgt cacaaggtcg aatttagaaa tttcagcagc ccgcttcaca tgttttaatg 2276041 tatcttcatc agcctgaaga cgaacggcaa gtttctctgc gattgatgtg actctcctaa 2276101 ccttatcagc aagagaacca agctcttcat ggaaaacgat attttcaagc ttcttcacat 2276161 ttgcatcaat gtttagtttc tgatcttctt tgtagaagaa tgaagcatca gataaacgtg 2276221 cgcgcagcac tttttcattg cctcgggcca cattttcaat cgcgtggctg ttgccgtttc 2276281 ggactgtgat aaagtgaggc agcaggtcac cgtttttgtc tttgacaggg aagtagcgct 2276341 gatgctcttt cattgtcgtg acaagcactt cttcaggaat tgacagaaac tcggattcaa 2276401 atgaaccgta aagagctgtc gggtattcta ctaaatgatt cacttcatca agaaggtctt 2276461 cgtcaactgg aatgctccaa ttgttttcag cagccattgt ttccagctga gattgaatca 2276521 tttgctttcg gacgctagga tcagcaataa catgctgtcc tttgagctgc tcttcataag 2276581 ctgaaggtga ttcaattgac acttcatgtc cgaggaaacg gtgtccctgt gttgtccgtc 2276641 cagactcaac gtttgtgatc gaaaatggaa tgacatcctg tccaaataat gcgacaatcc 2276701 atttgatcgg tcggatataa cgcaaatctt catttcccca gcgcatgttt ttcgggaaat 2276761 gcaagcttgt aattaaaccg ctcaattctg gcagaagcga cttcgtttct tggccggctt 2276821 ggaatttttg cacgaataca tactctatgc cttttacttc tttgatgtac aggtcttcca 2276881 catttgcgcc ttggcctttt gaaaagccga ttgccgcttt tgtccagttc ccgtccgcat 2276941 caagggcaat ttttttcgca ggcccttttg cttcttcttt tatatcatcc tgcttttctg 2277001 cgacatcctt aacgaacaca gcaagacgtc tcggtgtatt gaagagtttc acttcaccgt 2277061 gagtaatatt tttttcttta agccagcctg tcagcttgtc gccaagctga accatgcttt 2277121 cattcaaaaa gcgcgccggc atttcctcta atccgatctc taaaagtaaa tcctgtttac 2277181 tcatgagaag aaccctcccc tttaagcatt gggaacccta gtttttctcg ttcctcatag 2277241 taggtttttg ctacttttct agctaaattc cgcactcttg cgatatagcc cgtccgctcg 2277301 gtaacagaga tcgcaccttt ggcatcaagc aggttgaaag tgtgcgagca tttcagcaca 2277361 tagtcatatg ctggatgaac aagtccgttg tccatttgct tgatcgcttc tttttcatat 2277421 gtgctgaaca attggaacag catatcgacg tctgatgttt caaacgtata aacagaatgc 2277481 tcatattcag ccatcatgaa taaatctttt actgtaaacc ctgacgtcca ttccaagtca 2277541 aacacgtttt ctttatcctg gatataagac gcgagacgct caattccata cgtaatctct 2277601 acagaaacgg gtttacactc taatcccccg acctgctgga aatacgtaaa ttgtgttatt 2277661 tccattccgt caagccaaac ttcccagcct agacccgcgc agcctaaaga cggattctcc 2277721 cagttgtctt caacaaagcg aatatcgtgc tcaagcggat caattccaag agcacgcaag 2277781 gaatccaaat acagctcttg aatgttatca ggtgacggtt taataatgac ctggaactga 2277841 tgatgctgat acagtctgtt cgggttctcc ccgtagcggc cgtctgccgg acgtctggaa 2277901 ggctctacat aagccacttt ccacggctca ggaccgatac tgcgcaaaaa tgtatacggg 2277961 ctcatcgtgc cggctccttt ttctacatcg taagcctgca taagcacaca gccctgactg 2278021 gaccaatgct tttgcaaggt tagaatcatg tcttgaatat tcatttcaag cacctccact 2278081 tttctttcat aagttgactg cggcagcaac caaaaaactc ccgtctctat gcttgccagc 2278141 cgcaaacata gggacgagag ttctcccgcg gttccaccct agttgctgag aacaaaatcc 2278201 cagcctcttt tttaaaattg ctcaagaatg cctttcgttg cgtgctcatc cttagcttac 2278261 accgccctaa ggtcgctttc atgaggtaaa cgcaagtact tctttctctc actgcaacat 2278321 attttataat aaatgatcat ataaaaagat ggaccaaatg tcaacttttg ttttcaccca 2278381 taagatgttt catgctttcc atttgatcta aaaagcgctt tgattttaaa tacaatcccg 2278441 aatattcttc gtaatataaa tcaatcactt gctttaattc agcttttgtt tcctctttta 2278501 aggacacatt gccgagtctc gacagatcaa aatagtaaaa gagccttaac agccttgccg 2278561 tttgcggttt aatcggtatc ctgtaaggat ctttttcaaa acagcggtgg catataaaac 2278621 cattatcacg aacagagaaa tgaaaggttc cgtcttggct tttacaatgt acacaatgat 2278681 tcagctcagg atacaggccc atgacaccga gcatcttcat ttgaacaatg aaggtgataa 2278741 catccggatc tgttccttca ttcaactgtt ttaatgattc taatatgaat tcaaataaat 2278801 aaggatttgg ctttttttct tctgtgcctc tgtcgactaa ctcagcaaca taggcagcat 2278861 atgctgttaa aaacaagtct tccctgatgc ctctcatgct gaggatcatt tccccctgct 2278921 gaagcgttcc gaggcccgat gttttttgca ttaagaaaga accatacaaa aagggctggc 2278981 tgactgctga taaacggctg ttcggttttt tggcgcctcg tgccataaca cctatttttc 2279041 cgtgttctct tgtcagtaat gttacgattt tattcgtctc tccgtaatca tttgtgcgaa 2279101 gaacgatccc ttcacatttt gtcagcattt ccgcaccttc ctcaagcagg agcggccaag 2279161 aggtttataa aattggataa tcaaatcggg ctagctcatc ttctagttct tcgggtcttt 2279221 ccatgttctc tttttccagt tctttaaaaa gaagatacgt atcaacattt cctgtttgag 2279281 aaaatacgtt ccaggtaaaa ttcaacacaa gaaacccacc tttctgtagt taaactagct 2279341 tacctaaact ccaaattctt acctttatct tgaccagatg tcctccattt catgttaaac 2279401 aaaatttgct aatgtatccc tgttcctgtg agataatgac acacacggga agagattaat 2279461 attcgtcctc tttaaagcca aaatcgcgaa gctgggacat tttattacgc cagtctttct 2279521 gcactttcac ccacaattca aggtagacac gggagcccaa cagtgcttca atatccgctc 2279581 tcgctctttt tccaacctct tttagaaggc ttcctttttt accgatcacg atgcctttct 2279641 gggaatcccg ctcgaccaca atcgttgccg ctacgtgcac agaaccgttg tcctgccctt 2279701 tgatggattc gatggccacc gcaatgctgt gcgggatttc ttctctcgtc aaatgcagca 2279761 ccttttccct gattaattca gaaatgataa atcgttcagg gtggtcagtt acctggtcac 2279821 tcggatagaa ttgcggccct tccggcaaat acgcttcgat ctgcgcgagc aaggtttcga 2279881 tgttatttcc ttctaaagca gaaatcggaa caatttcctt aaaaggataa cgtttgcggt 2279941 attcgtcaat tagcagaagc aattggtcgg gatgaatttt atcaattttg tttacgatta 2280001 agaatacagg cgtagacatc gtctgcaatt tctcaatgat gaattcgtcg cccttcccgt 2280061 agccttcctc agcattgatc ataaacaaga tcaaatcgac ttcttttaat gtattttgcg 2280121 ccactttcat cataaagtcc ccaagtttat gcttaggttt atgaatccct ggtgtgtcaa 2280181 taaaaatggt ttgtgatgtg cctgtcgtca gtactccttg caccttgttt ctcgtcgttt 2280241 ggggcttatc gctcatgatc gcgatttttt gtccaatgac tctgttcaaa aatgtagatt 2280301 ttcctacgtt tggtcttcca ataatggata caaatcctga tttaaagctt tcgttcgtca 2280361 tgtaaatcct ccgatgaaaa tgcgcctggc aataattctt ccacagtcat ttcttttatt 2280421 tgtccttgta aattagtcag tacgacaata acgtcttttg tgcaaagctc agaaatcacc 2280481 tgtcggcagg ctccgcacgg agatactggt ccaggggtgt cagccgcaac ggccagcatc 2280541 tgaaactctg tatccccttc agaaacagct ttaaataaag cggtacgctc ggcgcaattg 2280601 cacatgctgt atgccgcgtt ctcaatattg cagcctctgt acacttttcc atccttggta 2280661 agaagagcgg ctcctacttg gaatttggaa tacggcgcat atgccatatc acgcgctttt 2280721 aaagcttctg ttattaattc ttgtctgttc atgtgtacat tcctctctta cctataatgg 2280781 taccgctatc actttatatt ttacataatc gcgcgctttt tttcacgccc atttctaaaa 2280841 atgtaaaata aatgtaagaa ttttcagcca ttacagcttt ggcaaaaaaa taagtaaacc 2280901 aatgatacac gaaatcacgg caaaaacgca aacagccccg gcggcagcgt ccttggccgc 2280961 tttagcaaga gggtgatgtt tgtcagttat taaatcaacc gtatgttcaa tggctgtatt 2281021 taaaagttca agcgaaaaca taccacctat caaaaggaat ataatcatcc actcaataat 2281081 gctgagctct acaaggaagc cgcaaatgag aacagcgcag gcggctgcgg catgaaattg 2281141 gaaattccgc tccgtccgcg ctgtttccca tatgccccgg cctgcatgca cgaagctttt 2281201 gaagaatcga ttcagctcat ttctatgatc ttttgagtcc ataagcgtcc agcaattcct 2281261 tttgcttagt aaacatctcc tcttcttcct ctttcgtcat atggtcatat cctaaaaggt 2281321 gcagaaatcc gtgtacagct agaaatccga gctctctttt aaaagaatga ttatactcct 2281381 ctgcctgctc tcttgtgcga tcggcactga tgataatatc acctaaaacc ggaggcattt 2281441 cggcgcccac gatttcgatc tcgccttctc cctcttcttc aagagcaaat gagatgacat 2281501 ctgtcggagc atcctttccc cggtattctt tgttaatctg atgtatgtca tcattggaaa 2281561 caatcgtgac agaaacttca gcctgatcct gaacgccttc acgctcagcg gcaaattgaa 2281621 gcagattttc tacttctttg agcatctctt ctgagacgct tcccgtttca tcaacgatat 2281681 caatcagtaa actcatctat ttcaccttct tagtagcctc cggatattca atccgggagt 2281741 ggaaaattcc ttttaatgtt gcacagagcg tttttgcgat tgtatccagc tctttaaatg 2281801 tcaaatcgca ttcactgaac tgtccgtcct gaagcttatc ggatataata ccccggacaa 2281861 gcttttcaat tcgttcagga tttggattgt gcatggatct gacggccgct tcaacactgt 2281921 cggccactga tataattgcg gcttcctttg actgcggctt cggtcccgga taacggaact 2281981 cttcctctgt aatctggtcg cctttttcct tcgctttata gtaaaaaaac tttaaaagcg 2282041 aggttccatg atgctgctca gcaatatcga caagctcttt cggaaattta tagcttctca 2282101 gcatattcgc accgtctgtc gtatgcgaga taataatatt tttgctcaac tgaggtgaca 2282161 gcttgtcatg cggattgtca atattcattt ggttttcaat aaaatattgc gggcgctttg 2282221 tttttccgag atcgtgataa tatgcgccga ctcttgcaag caaaccatta gccccaaccg 2282281 cttcacaggc tgcctctgat aaattggcaa ccattacact gtgatgatat gtacctggtg 2282341 tttccgtcag tattttgcgc aatagcggat ggttaggatt agacagctcg agcagcctca 2282401 tggtggataa aatgccaaag cccgtctcaa aaaacggcat cagaccgatg atcaatacag 2282461 atgaagcaaa ccccgacaca acccccatga gcattaacgt gccgatttca agacccgaca 2282521 gcgcagtgtt ctggatcaat aataaggata gaacgacaac catattaata aacgccacga 2282581 aaagtccggt ctgcaaaatc tttgatcttg cattgtgttt tcctaaaaat aatacacctg 2282641 aaatgccgct gatcaaataa taaatcccta tgacataatt gaatgttcct gtcacaccct 2282701 gattaaacat catacttccg caaatcgcaa gaatgatact tcccaaaatg gcaatgcgtt 2282761 cattcatcag cagtttgatt aagatggcgc cggccgcaat ggggaccaga tagccgatat 2282821 tattatactc catcttctga aacaaactga caacctccat gatcacaagc aaaagtgttg 2282881 tgattatgga gaataacaga atggattggt ttttaaactt cagattttgt ttctgttttt 2282941 caaaataata tacaagtgtt gcaatgaaaa gtccgatcat aatcaatagc ccgctgatcg 2283001 gtttaaagag atttgagtta tttaataacc cggtcagctc aagtttcctg tacacttccc 2283061 gatcaatgag gtcattttct tccacgagca cttgcccctg tttgatttga acctgctgga 2283121 cattatctga ggcttcctgc cgttttgcct ctgttgcttt cggatcgaag acgtaattcg 2283181 gaataatagc aaaacgcccg atttctgtcg cggctcccaa gtatttagac ggaatagaat 2283241 tgctctttag ctctttttct accttatcct ttgcatcaga tagtttatcc gaagggattt 2283301 cactgctcat gaccgtattt accgcggtaa tgaccgtatc tctgacaaaa gaaaagtctt 2283361 cactgtctgc tttcagcaat gtcttgatgg aatcctccga tatagaatca ttcacatctg 2283421 atgtcaattt gtcctttaca gatttgacca ttgatttttc cgatggtgat ttactgcctt 2283481 cttccgatga ttttttcact tcactaatac tgtcgaatat tgatgacaca aggtcaatcc 2283541 gattgtctgt atattctttt tttaatgtat attgatcttc aaccgcgtcc tcagcggctt 2283601 gctttttttc ctctgtggct ttttgatctt ctacggttgc cggagcgtaa atggtcttgt 2283661 cgctgactga aaacaggtct aaatcaagtg tttccggctt aacatgtaca aagagcaaag 2283721 caaacataat ggcagccagc agaagataca gcagtacatg catggagcgg gcatttttaa 2283781 aactgctcca tttttttgag ctgcttttgg tcttagcctt ctttttcaac acaagaacct 2283841 cctcttgaaa catcaagccc ataagcaatc ataaaaatga cccgataacg cgcgatcggg 2283901 tcattcagca ttaattttgc ttatcgtatg cttcaataat tttcgcaaca agcggatgtc 2283961 tgaccacgtc tgtctggtct agctcaatca tagaaatgcc gtctattcct ttcagcatct 2284021 ccttcgctac tgcaagtccc gatttgacgc ctttcggcag atcaatttgg ctaacgtcac 2284081 ctgtaatgat cattttagag ccaaaaccca gtctcgtcaa aaacattttc atttgagcag 2284141 gcgtggtatt ctgtgcttca tcaagtataa cataagcatc atcgagcgtc cgtcccctca 2284201 tatatgcgag cggagcaatt tcaatgatgc ctctttccat cagacgttct gtatgatctg 2284261 ccccaagcac atcatggaga gcgtcataca gcgggcgcaa ataaggatct actttttctt 2284321 ttaggtcacc tgggagaaaa ccaaggcttt caccggcttc cacggcaggt cttgttaaaa 2284381 tgattttttt gatatgtccg ttttttaaag catggactgc ttttacgaca gccaggtacg 2284441 ttttcccggt tcccgccgga ccaatgccga atacaaggtc attccgcttc atagcggcca 2284501 cgtattcccg ctgtcccatt gtttttacac ggattgattt gccttttgcg ttttttgtaa 2284561 tttcttcttc atacatgctt tcaaagtatt caagttcatt cttctttgcc attttgatgg 2284621 cgtaaatcac atcacgttca gagatctcta tccccttgcg aattaaagcg aggagcgatc 2284681 ccagcagcct gtctgcaatc tgaaacgatt catcatcgcc tgaaacataa atcgtctcgc 2284741 cgcgcgtaat gatatttaaa ttcagatctt tctccatcaa tttcaaaaaa gaatcttggt 2284801 tcccgaagag tgaaagcgcc tcgtccgggt ttttcagttt ttgattcatc gcaagtaaat 2284861 gttctgtcat tcttcagtct ccctgacaat aggtgtggtt tgaacgatat cttctataac 2284921 ttggtagaga ataatcaact ttactttacc attctcaaca gtctggtgca aaactttttc 2284981 acttttcacc tcgccgtttt cgcctatttt atcctctaca tcctgtttac ccaatttaat 2285041 gccttcttga actgcttctt cttttgtata ttttcgcaaa gcctcttcac tttctctcgt 2285101 ttgctctttg acataggata cagggagctt aaatccgaga aaatgaagcg aatgcttttc 2285161 ttgttctgtt tttggatgct tcaattcctc ttttttaaac gtcatccccc agatcgggat 2285221 tgccaaagaa ccaaaagaaa gcttgtgctt tgtccttact ttgcccgtat agacgttaaa 2285281 taatgtttca agcgggactg tcacttctga tctataccag gtttctccat aaatttctgc 2285341 ttttgaggcg acttcctgct gatggtcttc gctgccgatc agtcccgaaa caagcagctg 2285401 tcccttttca acatgatcgt gtatggcggc catgggctgt cctttttgca caaacattct 2285461 cgtaatggtt gctttctttt tggcgacaat attgcgcggg ctaacatatt tttctttttc 2285521 gggctcattt ttctccacaa ctttcatatg aatggtcgtc cccttcagat caactccgac 2285581 ccaagtgata ttgtctattc cattggttaa tgatttctgt attttttcgg gcgacatcat 2285641 taaaaactgc agacggccct ttttgacgcc gatttcatta agatgctgcc tcatttgatg 2285701 ttctgtttca ggcttagcgc ctgtcacatc aattttccac accatattgg acagcaaaaa 2285761 caaaagaatg aaaaaaatcg caaaaccgat cgtaaaccct atattcagct ttgatttcag 2285821 caacaggaag ggaaatccct tccgattgat aaatcgggct ttacatttaa atttacttct 2285881 tacccgccga aaggcatgta catcctgaag ctgtatatat aacgatacgg cttctttctt 2285941 ttttttgaca tgaaagaccg gaatcccctg tcttgtgcat tcattaagga gccgctcaat 2286001 ccctcttccc gtcaattcaa gctggacctt acccgaaaaa aaagacagcc atttattttt 2286061 cacaacattt ccccctcggc tttatgactc aacatatcga acgacatcaa tcgtaccctc 2286121 caaaagtatc tcttccggaa gaatcgcctt gatgacaaaa tttttaccag atatgatgca 2286181 ctggccctgc ttcagcatca gccgcacttc attctcactg aaaagcaaaa ggcctctgtg 2286241 gttttctatg tagatatgaa gtctgccaac cattgtaatc ctcggcagat ccatcataac 2286301 gtccggggga atttccaatg ctcttgtcag ccaagctttc atacgattct ttctttgccc 2286361 catacaaaaa gaaccccctt tcatctcata tgtatgattt gaaaggaggt tctaacactt 2286421 taatttttac gggccgggcg catcgtacgg tgaggttttt tcgcccgtgg aggtccgaac 2286481 acctctccta gaacgatccc ctgtacgacg gtgtctttat tcacctgaag cattttttgt 2286541 tttgtgtata ctgttttttg tttggcagca gcaagatctc gttccagccc tttcaggttt 2286601 cttgctgttt ccctgcgtct ttcttccgct tcccgtcttg cctgttccat acggttaggg 2286661 ataggtgcag gggcatcttc ttttgactgc ttcttttgag gagaagcaga ttgcacgtgt 2286721 tgaggttttt ttcttttttg gctgttttgc ttttcttctt tgctcttttt gccgaaaatc 2286781 gcagaaatga ttccgatgat cgctgcaata ataagcggat tggtcagtaa atcttccatc 2286841 agcgttctcc cttcttagag agattatgat ttgcggtctt catccgaagg gtctttcgtc 2286901 agcttgccga atgaatcacg catttctgtg tcagcatcga tgttcttgat attcatgtaa 2286961 tccatgacgc caatattccc ttcacgcaaa gcttctgcca tcgcaagcgg cacttccgcc 2287021 tcggcttcta ctactttcgc gcgcatttct tctacgcggg cacgcatttc ctgttcttga 2287081 gcgacagcca tcgcacgtcg ttcttccgct tttgcctgcg cgatgttttt atcagcctcg 2287141 gcctgatcgg tttgtaaaat tgccccgatg tttttgccga tatctacatc tgcaatatca 2287201 attgagagaa tttcaaacgc agttcctgag tccaatcctt ttccaaggac tgtctgagaa 2287261 atcatgtcag ggttttcaag cactttttta tgattatcag atgaaccgat tgtagaaacg 2287321 attccctcac ctacacgagc tacaatggtt tcttcccctg ctcccccgac gaggcgctcg 2287381 atattcgctc ttactgtgat tctcgctttc gctttcactt caatcccgtc cattgcgacg 2287441 ccggcaatga acggtgtttc aatcacctta ggattaacgc tcatttgaac agcttccaac 2287501 acgtcccggc ctgcaagatc aatggcagca cagcgctcga atgtgagttc aatgttagct 2287561 cgctgagcgg cgataagcgc gttgacgact ctgtcaacat tacctccagc cagatagtgg 2287621 ctttcaagct ggtttgttcc aacattaagt cccgctttat gcgctttaat cagcgggtta 2287681 acaacccgat tcggaatgac gcggcgaagc ctcatcccaa ctagagtgaa aatgctgatt 2287741 ttcactccgg ctgccaaagc tgaaatccaa agcattacag gcacaaatgt aaaaaatact 2287801 gccaaaacaa tgatcgctac tgcgacaatt gccagaatca taagtgttga cggatccata 2287861 taacttctcc tcgtttctat ttaaatttct ctcacgacaa tgcgtgagcc ttctactttt 2287921 atcactttta cttttttatc tttttctgta aacgatccct ccgatacaac gtcaaggcgt 2287981 tcatcatcaa taatcacggt accggaagga cgcagcggtg taaaggttat acccactttt 2288041 cccattaagt ccgtgcgcgt ttgatttgaa acgtagccgc tctccgtgtt tgtagaatca 2288101 tttaatatca atttcttaaa gaatttcata cgctttccca acacccttgt cagtaaaata 2288161 aaagctgtaa tcgaaacagc tgaggcgatc aagagagaaa ccgccatgac agtgaagctc 2288221 cccgcggcta aaaacaggct cgcaataatc gctcccaagc ccagtaatcc aatgattcct 2288281 ccgggaagaa aaatctcaag cagaatgaga atcacccctg ctataaagag gagaaccgtc 2288341 tcatacccgg caaggccggc tgcaagatgc ccgtaaaaga acagcaataa cgcaatgagt 2288401 ccagccgttc cagggaggcc gacacccggg gaaaaaagct ctaccgtcag acctaaaaaa 2288461 gcgattgtca gcagaatagg gacaatgacc ggattcgtca gccatcttgc cgtcttttcc 2288521 gcaaagctct cctttgcata gctgatctgc gccttttcga acccaagctt ctttacgagc 2288581 gtggacaaat tgtcagcagt gccttctgaa tagcctacct caatcgcctt gtctgcgtta 2288641 agtgtcagca gatctccctt aggcgcgcca acttccttgg catctatatc tgggtcagcc 2288701 attgcgagcg catattttgg atcgcggtta tttttcactg cggcatcttc catctctgcc 2288761 agccaaagtg attgagcttt ttggtcagcg gcattgcctt ggccatcaac aatcgcggcg 2288821 gctcccattt ttccgccagg cgccatataa atgtgatctg cttgaagtgc aatatatgca 2288881 ccagcagaca acgcgcgttt gttgacatat gcagttacgg ggatctcgct ttcggttatc 2288941 aaatcggcca tatcaatagc agatttgacc aatccccccg gggtattgat atcaagaata 2289001 atatggtctg catgtgcatc ctttgcgtct tgtaacgaac gggacaaaaa cgaggcgaga 2289061 ccctgttcga catttttttc aaccgggatc acataaacag tttgtttttc tgcttttgcg 2289121 ttcagctgta cgcctaataa agaaagtaaa aatataccca aaagagcagc acggaatcct 2289181 ttgatttgaa gcaagggcgg tgtatccctc cttcctttta taataagtgc cttctcttca 2289241 tacgtaacaa atgtatcaaa ggtttcattt ttttatgtat aaaaaaagac atctctctta 2289301 gaaagatgtc cttttctttg ccatttaaga cagttgactg ctcacaagct tattaattaa 2289361 acttccgtca gctttacctt ttactttagg cataattgcc cccatcactt tgcccatgtc 2289421 cgcttttgag ctcgcaccga cctccgcgat ggtttcattt acgattgtac gcagctcttc 2289481 ttctgacagc tgctcaggta aataaacttc taaaatgtcc agctcttttt gaactttatc 2289541 tactaaatct aaacgattag cgtttgaaaa ttcctggagg gagtctttac gttgcttaag 2289601 ttcacgagaa aggacagtga gttcctcatc ctcggtcaaa ctgtctttct taagcttaat 2289661 tgcttcattt tgaagtgaag ccttaaccat tcgaacgaca gtcagtttgt ctttctcacg 2289721 gtttttcata tacagcttca tatcctggtt gagacgctca agaagactca taaatccacc 2289781 ctcttttaga atttgcgttt tctagcagct tcagactttt tcttgcgctt tacgctaggt 2289841 ttttcataaa attcacgctt tcttgcttct tgcaaagtac ctgtctttga tacactgcgt 2289901 ttgaagcgac gaagagcatc ttcaagcgat tcgttttttc taacgaccgt ttttgacatt 2289961 ctctttccct ccctccgaat acaccaatcg actaccttta agttacacat ataaacatgt 2290021 actttgacat tataatataa gccatcagtc aggtcaacta agtgagttca cttttccgtc 2290081 atgagtgcga ctgcctgtct atataatgaa agaaaggggt tggtgaatag gatgttaatt 2290141 ctgattagct ttactgctct tatattattc tttctcgcag gcatgaacat gcttcgaaag 2290201 ggcttaattt caatggcgta ctcaaaaatt gaagaacgtt tgcttttatt tacagaccat 2290261 ccgttaaaag cgtttcttat cagtattgta tttacgggga tacttcagag cagctcagcc 2290321 tttatggtca ttgtcatcgg ctttgtaagt gcgggcgttc tttcttttaa gcggacgatc 2290381 ccgatgattc tggggacaaa tgttggctct acttttacaa ctgaatttat tgctatcaaa 2290441 atggatattg tgatttgggt tcttttaata ggaggtttat tgttttttct gactggcagg 2290501 tatcctttga aacagctggg aacaagcttc cttggactgg gcatcatctt cttttgcatc 2290561 agcggattca gccatcttgc cgggccgctg acaaagctga aaacgggcgc cgacgttcta 2290621 taccatgtta acgattcaaa ctggtccgct ttgctcatcg gcatggtgtt aactgccatc 2290681 attcactcca gttctgtctg tatcggcatt ttgatgagtt ttatgaatga agggattatc 2290741 ggactgacac aggcgatgag cgtcgtactc ggatcaaata tcgggacatg cattacagct 2290801 gtcatggctg ctgtatccgg cggatatgcg gcgaaacaga cagcatatgc ccatgtggta 2290861 tttaacgtgc taggggtggc tctagtattg ccttttctga ccgcagcgac cggctttgta 2290921 gagcagttat cacctgatcc cgcacaaaag atcgcgcatt tcagcctttt atttaatgtg 2290981 gtgacagctc ttttatttct tccgcttaca aacttgtttt accgattgat tcaccttctt 2291041 atcccggcta aataaaaaaa tcggtacatt ttaatgcacc gattttttag gttaagaaga 2291101 caaacgcatg tgttcagtta tttcatcctc aaccacacgg acaaactgtc cttcgttgta 2291161 aggataacct gcttttagga ttttgacttt tacgattttg ccgatcatat cttccgtacc 2291221 tttgaaaaca accttcatat aattgtctgt gtaaccgaca aacatatttt cttcttctgt 2291281 ttccttaaac gcttcctcag ggataatctc aagcacttca ttttcatact gagaagcgta 2291341 ttcttttgca agctggtcag aaagagcaat caggcggtgc acacgttcgt ttttcacgtt 2291401 ttcatccact tggtcttcca ttcgtgcagc tggtgttcct gtacgcttac tgtaagggaa 2291461 aacatgcagc tcagagaatt tatgttcttt aataaagtta taggtttcca taaattcttc 2291521 ttctgtttct ccagggaacc cgacgatgac atcagaagta acagctaagc ctggcagtgc 2291581 ttttttcaat ttatttaaac ggtctgcaaa gaattccatt gtatatttgc gtctcatccg 2291641 tttaagcact gtgtttgatc cggattggat aggaatatgc aaatgattca ctatcttatc 2291701 tgagcggtct aagacctcga tcacttcgtc agtgatttgg ctggcttcga ttgaagaaat 2291761 tctgatccgt ttcacgcctt ccacacgggt gtctaattcg ctcaaaagct tcgcgaagtt 2291821 gtaatctttc atatcttcgc cgtagccgcc tgtatgaata cccgtaagaa caatttcctt 2291881 atatccggca tcgacaagct gctgcgcttg tttaatgact tcttcagggt cgcgggagcg 2291941 gagcaggcct ctcgcccacg gaatgataca gaatgtgcag aaattattgc agccctcctg 2292001 tattttcaat gacgctcttg tgcggtccgt gaaagcaggc acatcaagct cttcatatac 2292061 tcttgctttc atgatgttgc tgacgccatt aatcggctgg cgttcttctc ggtattggtc 2292121 aatgtagcca agcatttttt cacggtcctg tgttccgact acaatgtcga caccggggat 2292181 cgccataatc tcagcaggtg aggtttgcgc gtagcagcct gtgacacaga tgacaccgtc 2292241 aggattttga cgaatggcgc gtctgatcac ttggcggctt tttttatctc ccgtatttgt 2292301 aaccgtacat gtattaatga catatacatc agctgtttgt tcaaagtctc ttctttcata 2292361 gcccgcttct ttgaaaagct gccagattgc ttctgtttca taatggttga ctttacagcc 2292421 aagcgtatgg aaagcaacag ttgccattac tgatcacctc ttaataactc tgtttgataa 2292481 gaaatcgcac tcaacgcgta tagcggagcg gtttctgtcc ttaaaattct cggtccaagg 2292541 ccgcacgtca caccgtcttg ctctgtgagc cgttcaacct ccgcttctgt taaaccgcct 2292601 tcgggaccaa atacgatcaa tagagatgat cctttcggaa ggctgcttac aatcgcgctg 2292661 aatgcgctta tttccccttg cttcgatgac tcctcgtatg caacgacaca tttatcgaaa 2292721 tcctgcatcc tttgaagaag ctgctgaaaa gaatggacat ccatcactcg cggcacttcg 2292781 ttacggtacg attgctcagc cgcttccttc gcaattttcg tccatctttc ccgctttttc 2292841 tttgcctttt tgtcatccag cttgacaaca gaacgcgcgg cttggaaagg aataaaggca 2292901 tgagctccga gctcagtccc cttttggata atccattcaa gcttatctcc tttcggaagg 2292961 ccgctcgcaa tatagacctt tatcggaagc tctctgtttt cattcgtcca ttctatcaca 2293021 aggcaggaca ctttatcttt ggaaacagat tgaagttcac attttgcctc gaagccgtct 2293081 tgagagcagc agataatctg atctccctca ttcattctca tcacgttcac aatatgatga 2293141 acttcttcgc cggtaatcga aaaagtcggc gcttcctcta tttgctgctt cgtgagctcg 2293201 ataaaatatc gttgcatacg ctgtgacacc tactaactgt tattttttcg caataatgct 2293261 gacccaatct tccattgaaa ggatttctac aatggtaaag ccagcttgtt ccagtgcttc 2293321 ttttacttct tgttttttat gaccgatgat tcctgacgta ataaagtgac cgccttcttt 2293381 taacaggctg tacgcttgtg aagtaaagcg aagaatgact tcagccaaaa tgttggccac 2293441 aatcacatca tgttcccctt caatcccgtc taacaaattg ttttgcttca cttgagcaat 2293501 atcgctgact ttgttcagct tgagattgag gcgtgcactt tctacagcca cgggatcaag 2293561 atcgtaggca tgaaccgatt cagcctcaag cattgcagcc gcaatactta aaattcccga 2293621 accagtgccg acatcaatca ccttatcacc cttttgcaca aagcgttcaa gcgcctgaat 2293681 gcagagtacg gttgtcggat gtgtccctgt gccgaaagcc attcccgggt ccatttcaat 2293741 aatcagttca tcagtatgga ccggcgtata ttcctcccac gtcggcacaa ttgtaaactt 2293801 ttcagaaatt ttcacaggat gataatactt tttccaggca gtcgcccact cttcttcatt 2293861 tacttcagaa atagtgatgt ggtttctgcc caaatcaata ttgtaaagaa ggagattatt 2293921 aatcgtttct ttgatgccgt ctacagtttc gcccagaaaa ctgttaaccg gcagatatgc 2293981 tttgacaatg acaccctcat ctgggtaatc attggggtcg agctggtaga tttccccgta 2294041 cacattctca cgttctttaa ttaaatcaag cgggtcctct atcacaaccc cacttgcacc 2294101 agcttcatgc aatatatttg agataggttc gaccgcttca tgtgttgtgt gaatgcttaa 2294161 ttcggaccat ttcaaaacta ccaactcctc atccaataat taatcgcctt taaacgcgcg 2294221 ttttaccttg tcaaagaaac tcatttcctg ttcgtcaggc aggtttccgc tgacttcggc 2294281 aaattcgcgg ataatgtctt tttgtttatc agtcagattt gtcggcgtaa cgacgcggac 2294341 gacgatatgc tggtcaccct gtccatagcc tctgacattt tgaacgcctt tgcctcttaa 2294401 tctgaatttc gttcctgttt gtgtaccggc cggaattttc aatttcactt ttccatgcag 2294461 cgtcggcact tctacctcat ctccaagagc agcctgagca aacgttaacg gcatttcaca 2294521 gtaaatatca tcgccgtcac gctcgaagaa ctcgtgtgcg cgtacatgga acacgacaaa 2294581 taaatccccg gcagggccgc cgtttattcc tggttcaccc tgtcccgaga gacgaagctg 2294641 ctgcccgtca tctacaccgg ctggaattgt cacattgatt ttcttgcgtt ttttgatttt 2294701 tcctttgccg ccgcagtccg cacatttgtt tttaatgatt ttgcctgtac cttcacagtg 2294761 gtggcagacc cgtctgttaa cgacttttcc aaacggtgta ttttgctcca cgtttaactg 2294821 gccggagcct ccgcagtggg agcatgtttc tggatttgtt ccaggtttcg cacctgagcc 2294881 tttacatgtt tcgcacgttt cctcgcgggg aatttcgatg gttgtttctt taccgaaagc 2294941 cgcatcctca aacgacaggg tcatcgtata ctgtaaatca gcaccctggc gcggagcgtt 2295001 tggatctctt cgtcttgtgc ctccgccgaa tatacttgag aaaatatcat cgaaaccaaa 2295061 accgccgaaa tcgccgccgc caaaacctcc gccgccgaag ccttggttag ggtcagtgtg 2295121 accaaattga tcgtaatgcg cacgtttttg gtcatctgac agcgtttcgt atgcttcttt 2295181 tacctcttta aatttttcat ctgatccggc ttctttgtta atatcaggat gatatttttt 2295241 tgacagcttc cgataagctt ttttaatttc atcctttgaa gcgctcttac ttactcccag 2295301 cacttcatag taatcacgct tactcatctc gcttcactct cccgaatttc tcacataaat 2295361 tagattgtat cattttgaat tatgattttt caattccttt tatcccgggc aagaaaaaaa 2295421 gtcaaagcca agagatgcct gactttgact ttctaatcat tgaatcagat tatgaaatgt 2295481 gttcttttcg gtcagctccg gaagcggggc tgacactaaa aagaacttat tttttgtttt 2295541 ggtcgtcgtt tacttcttcg tattcagcgt cgacaacgtt gtcatccgct ttgccttcag 2295601 cgtttgctcc gccttgagct tgctgtgctt tagcagcttc ttcataaagc ttcatagaaa 2295661 gctcttgaac gattgtttga agctcatctt ttttcgcttt gatctcttca aattcgtttt 2295721 tctcaatcgc tgcttttaaa gcgtctttgg catcgttggc ttttttcact tgttcttcgt 2295781 ccactttgcc ttcaagatct tttaatgttt tctcagtttg gaaaacaagc tgatctgctt 2295841 cgttgcggac ttcgatttct tcttttttct tcgcatcagc gtcagcattt tcttccgctt 2295901 cttttaccat gcgttcgatc tcttcatctg agagacctga agaagatttg attgtaatgt 2295961 tttgttcttt tcctgtgcct aagtcttttg ctcttacgtt tacgataccg tttttgtcaa 2296021 tatcgaaaga aacttcgatt tgaggcacgc cgcgcggtgc tggcgggata tcagtaagct 2296081 ggaagcggcc gagtgttttg ttgtcggcag acattgggcg ctcaccttga agaacatgga 2296141 tatcaacagc tgtttggtta tcagcagcag ttgagaacac ttgagatttg cttgttggga 2296201 tcgtcgtgtt gcggtcgatc agttttgtaa acacaccgcc cattgtttcg ataccgagag 2296261 aaagcggtgt aacgtcaaga agaacaacat cttttacgtc acctgtgata acgccgccct 2296321 gaatcgcagc accaagcgct acaacttcat ccgggtttac gcctttatgc gcttcttttc 2296381 cagtttcttt tttgattgct tcttgtacgg cagggatacg agttgatccg ccgacaagga 2296441 tgactttgtc gatttcgctt gcagaaagtc ctgcatcttg aagcgcttga cggacaggac 2296501 ccattgtgcg ctctactaaa tgagaagaaa gctcttcgaa tttagcgcga gttaatgtaa 2296561 gttcaaggtg aagcggtcct gcttctccag ctgtgataaa cggtaaagaa atttgcgtag 2296621 aagatacgcc ggaaagatct tttttcgctt tttcagctgc gtctttcaaa cgctgaagcg 2296681 ccattttgtc ttttgacaaa tcaatgccgt tttctttttt gaattcagac accagatgat 2296741 cgatgataac ttggtcaaaa tcgtccccac ccagacggtt gtcgccggca gttgaacgaa 2296801 cttcgaatac accgtcgcca agctcaagga tggaaacgtc gaatgtaccg ccgccaaggt 2296861 cgtatactag gatcgtttga tcttcatctg ttttatcaag tccgtatgca agcgctgctg 2296921 cagtcggctc gttgatgata cgttctactt caagacctgc aattttacca gcgtcttttg 2296981 ttgcttgacg ctcagcatcg ttaaagtatg caggaactgt gataactgct tttgatactg 2297041 tttcgccaag atagctttca gcgtatgatt taaggtgttg aaggatgata gcagacactt 2297101 cttgtggagt gtaatccttt ccttcaattt caactttata atcagtaccc atatgacgtt 2297161 tgatagacat aattgtgtta gggtttgtaa tagattggcg tttagccact tcccctactt 2297221 gacgttcgcc gtttttaaat gcaacaactg atggcgttgt gcggtttcct tcagcgttag 2297281 caataacttt aggctcgccg ccttcaagca ctgccacaca tgagtttgtt gttcctaagt 2297341 cgattccgat aactttactc acttgaataa cctcctgcta tgtaattatt gattcacttt 2297401 gaccatggaa gggcgaatga cgcgatcctt cagcttatag cctttttgca tttcctcaac 2297461 aacaatgttg gagccgtagt tttcgtcttc agcctgcata acagcttggt gcagattagg 2297521 atcaaattcc tgccctacag cttcgatggc ttcgacgcct tcttttttca aggcttctac 2297581 gagctgacgg tggaccattt ccattccctg gagcaaactt ttcgtctgtt cattgtcggc 2297641 ttcaacctga agcgctcgtt caaaactgtc aagagccggc agcaaatcag tcacgatatt 2297701 ttgagaacgg tatttttggg acgcttccat ctctaaacgg ctgcgtcgtt tatagttttc 2297761 aaagtctgct tgaacacgca aaagtttgtt ttctttttcc tcaagcaaac cttgcaattc 2297821 gttaatttgg ttttgaagaa gttcgctttc atttgtttct tcctgctgtt catcagcggc 2297881 agcttgttct tcaatgattt cttgctcttc tgtttcgttt tgttcaacgg tttgtttttc 2297941 ttctgacatt gtgttcacct ccctcaaagt gtaaggagaa ggacaggtgc tgcccttcga 2298001 taaaatttgc caaaattccc ttattcatca tacagacttg ttaatgcttt tgacaagtcc 2298061 gaagtcacat gctgaagcag gctgacaacc ctggaataat tcatgcgggt cgggccgata 2298121 atcgcaattg agccgatctg cttctggtct acggaataag aagccgtaat cagactgcaa 2298181 ttttccatct cttcatagtc gttttctttt ccgattttaa tcgaaattcc cgtgtgcggg 2298241 gattgaacca gctttaaaac atcctgttct ttctcaatta atgaaagcag cgaccgaact 2298301 cgggtgatat catggaactc aggctggttc agcatattga ttttcccgcc aaaaaacaac 2298361 ttttcaacgt gatttgtgga atgaaaggtt gaacgaagcg cgtcgagtat attgtcatag 2298421 tttttaatgt gctgtcttag gtacatgaca acttctttaa atatgcgctc attcagttca 2298481 tccattggaa cgccgcttaa acggtcgttc agtatattta ccagtttttc aatatcagac 2298541 agatccattt tggtcggaaa gttaatcgtt ttgttttcca catgccccgt attggtaacg 2298601 agaatcgcta ccgccatatc aggctgaatc ggaatgattt gaatctgttt aaggtaattc 2298661 tcactcaact tcggcccgag tacgatggat gtgtaattcg tcagatcgga caaaatttgc 2298721 gctgattttt gaactgtctt ctccagctcg aaaattttct ctttgaagat cgagtggatt 2298781 tggtccaggt cgcttttcgt caatttgacg ggtgacagca aatggtcaac atagtaccga 2298841 tacccttttt ctgacggaac acgtcctgag gatgaatggg ttttttcaat aaagcccaat 2298901 tcctccaagt cagccatctc gtttcttatt gttgcagagc taaatgtgat ttcatctttt 2298961 ttcgaaagag ttcttgatcc caccggctgt gccgatttaa taaaatcgtt gattataacc 2299021 tgaaggatca gcagctgacg atttgttaac atcatcatca cctctgttag cactctcaat 2299081 aagcgagtgc taattctata acaaaagtat caaaccacaa gaaaaatgtc aattataact 2299141 cacccaaaaa agcgccaaaa acttcattgc ctaataattt cccttgatga gtcaaataaa 2299201 cggcagactc cgaattgtga atcagccctt tttcagcgag gtcttttaac acgcttggga 2299261 aaagtccatc cagggaacgg ccgtattttt ctgcgaatcg ttttttgctg acaccggctg 2299321 tttttctcaa acctaaaaac atttcttcct caatctgttc ttctgttgtc acttcatgtg 2299381 tatctctgta cggaaaaccc ttttcagcta tcaggtcaat gtaatgctta acaggtccga 2299441 cgttcactgt tcgtgtgccg ccaatatatc cgtgagcgcc agctccgaaa ccgaaatatt 2299501 gttcgttgct ccaatacgtt agattgtgct tagattccat gcctgcctta gcaaagttgc 2299561 tgatttcata ttgatgaatg ccgtgagctt ccatcttgct catcactatt tcatacattt 2299621 cagcttcctg ctcctgcggc ggaagatgaa gccgcccttt ttgcatcaaa ttataaaata 2299681 ccgttttcgg ttctacaata agggagtaaa cggaataatg ctcagcgtcc aatgataaag 2299741 cagtgtttat ggaatgttcc agatgcttga gggtttgccc cggaagcccg aacatgagat 2299801 caagactgat attctcaaaa ccgatttccc gcgctctttc aaaagaggtg aatacatctt 2299861 tttgcttgtg cactcggccg attttttcta acagatcgtc ttcgaacgtt tgcacaccaa 2299921 agctaaggcg atttacgcct gcttctttta atatttttaa tttctctgcg gacaaatcgt 2299981 ccggattcgc ttcaaccgca aattccgata agtcgcttga gggctttagc acgcggttga 2300041 tcatatccat cagcttttta agctgttcct cagacaggga ggtcggcgtg cctcctccga 2300101 taaagattgt tttgagatca ggctgcccgg tttttgctat tgtatttatc atttcctgtt 2300161 cgagtgcgtt taaatactcg tcgactggct gactttgaat aaaatattta ttgaaatcgc 2300221 agtagtggca aatatgctca caaaatggga tatggatata agctgatttc aacggattca 2300281 ccttctttac agaaagaagc cgcagtacaa gactgcggcg gcttctattg ttttttcgga 2300341 ctgtcgtcca ttttcagaac tgccataaat gcttcttgcg gcacttcaac tgagccgacc 2300401 tgcttcatac ggcgctttcc ttctttttgt ttttcaagaa gtttccgttt acgcgagatg 2300461 tcccctccgt aacatttagc caatacgttt ttacgcattg cttttatggt ggagcgggcc 2300521 acgattttct ggccgattgc ggcttgtacc ggaacttcaa actgctggcg cggaatgagt 2300581 tctttcagtt tttcaacgat cacttttccc cgttcatatg cgtaatcacg atgcacgata 2300641 aaggaaaggg catcgatttt ttcaccattc agcataatgt ccattttcac aagcttggac 2300701 ggtttgtagc cgatcagttc ataatcaaag gacgcatagc ctttagtgct tgatttcagc 2300761 tgatcaaaaa actcatatac gatttccgct aatggcatat cataaatgat gctgacacgg 2300821 tttgcgtcta aatactgcat atcaatgaaa ttgccgcgtt ttccttggca aagctccatt 2300881 acagcgccga catagtcatt cggcaccatc atcgtcgctt ttacgtatgg ctcctcaacc 2300941 ctttcgatct tttgaggatc cggcatgttg gacgggttgt cgacaacgac cttttcgccg 2301001 tctgtcatat acacgtcata gataacgctt ggcgctgtcg taatcaggtc gatgttgaac 2301061 tcacgctcaa ttcgctcctg aatgatctcc atgtgaagca tgcctaaaaa tccgcagcgg 2301121 aacccgaatc caagcgcttg cgaagtttcc gcttcatatt gaagggagga atcattcagc 2301181 tcaagctttt caagagcttc ccttaaatca ttatacttcg ctgtatcaat cggatacaaa 2301241 ccacagtaca ccatcgggtt tagcttgcgg tatcccggca gcgcttcttc tgcaggattg 2301301 gcagcgctcg ttattgtatc accgacacgt gtgtcaccaa catttttgat tgaggcagtc 2301361 aggaagccta catcaccgac cgtcagttca tttgtcggag ttgctttcgg cgtgaacacg 2301421 cccacctctg ttacttcgaa ttctttgccg gttgccatca ttttgatttt ttgtcccggc 2301481 tttaccgttc cttcaacgac tctgatataa gccacgacac cgcggtaggc gtcataaagc 2301541 gagtcgaaga tcagcgcttt gagcggcgcc tccggatctc cggtcggagc tggcaccttt 2301601 tctacgattt gttctaaaat ctcctcaatc ccgataccgg cttttgctga agcaagcacg 2301661 gcttctgatg cgtcaaggcc gataacgtct tctacctctt ggcgcacacg ttcgggctcg 2301721 gcgctcggaa ggtcgatttt attgatgacc ggaaggattt caagatcgtt gtcaagcgct 2301781 aagtagacat tggcgagcgt ctgcgcttca atcccctggg ctgcatccac gacaagaatc 2301841 gctccctcgc aggcagcaag gcttcgggat acttcatacg tgaagtcgac gtgtcccggc 2301901 gtatcgatta gatgaaagat atattcttct ccgtcttttg ctttatattt aagctgaaca 2301961 gagtttaatt taatggttat gccccgctca cgttcaagat ccatagaatc gagcaattgt 2302021 tctttcattt ctcgttgagt gattgccgac gttttttcta aaatacgatc cgctaaggtc 2302081 gattttccgt ggtcaatatg ggcaatgata gagaaattcc gtattctcga ttgcctctct 2302141 aaacgctttt ctttatctgt cacaatctat cactcctact attaaacgca aaatacacta 2302201 gcttagatta tatcaatagg attgtaaaga ttcaatgtaa aacaagaaag agaaaagttc 2302261 cctatcatat ctgggttgct tttctctttc acgtacttat tgattcatat cccgtatcca 2302321 ttcatacatt gactgggcag tattggttac ggtgtccgaa agcgcttttc cggcttttga 2302381 aaacatattg aatgtctcca ccttttccag ctctttttgt ttttctacta aatcttttgc 2302441 cgtgactgtt tctcctagga ttgaggcttc tttttcatta tcttttccgt cggtgagcgt 2302501 aaacgccccc ttcagtgaag ggtcatgata gcctttcata ctcagcatcc cgtggtttgc 2302561 ctgctgcatg ccgaacagaa cgcctaaaaa catgatcgtg acaagcagta agcactttcc 2302621 aaagtatgca atcaaatcaa ccacctattt cttattgttt tttcgtctcc ccgctcgctg 2302681 cgttgacctt ttcagcatcc cagtacattt cgctgaatac gtccgcggcc gcgttagccg 2302741 cacgctgcag ctcttcgaga ttattatcca ctccgccaaa ctcgagcaaa agcgctctat 2302801 cggttaaatc ctgattgtaa acaccattat cgcctggcga gcctttggaa aagacacctg 2302861 tgctaagtcc ggggtatttt ttctccatca gtttatgaag ctcactcgca attttatagt 2302921 tttcttcgaa gtttttgctt tttttcccga cgacaaaggc taccctggca tagcttttcc 2302981 ctttaatcgt tgcggttgtg tcttttttgc gccgagagtc tctgtggatg tcaatgatat 2303041 attgcagatt tttgtttgaa gcgagggcgt ctttcacgac cggccttgat tcatcatagg 2303101 acctggcata gtttaagcct tttttattca attttgactg tatatcggtt ttattcactg 2303161 tggctccgat tccctgggat tcaagcgctt gtccgaacat atctcctaca agcgtgacat 2303221 tggctttaga atggcgcgcc atgtcaggat cggtctcgcc ttttaataga gggagatatg 2303281 attccgtatt gtgcgtgtga tagataaaca cgaccttttt atcacctgtt gtttgtttcg 2303341 gcggatcttt ttgcgcatta tctgattgcg tttgctgttt ttcaatctct gccaaattcg 2303401 cttctctttc ttcctccatc accttagacg gcggcggcga ttccgcaggc atattcgtat 2303461 aatccgttcc ttgtccagct aacaaaatct cggtatcaaa ttgtgcaaat cctggcagct 2303521 cccgaccgag aaagctccgc ggatcttcga ggttaatgct cgtcgccagc tttaaagaaa 2303581 gacgagaaag atgaaatgag ctgtctgttt gagagaggtc agaagcgaaa taatggtttt 2303641 ccatctgcag caaatgtgca aatacgtcac ccggcaattc ttcagcaatc ccataaaaag 2303701 agtcagacga cggcctaagt tccggccgga gagacgtcag cacaccggat agaacaaaaa 2303761 tcacgataag gcttacgata aatagaaaga tggcttttac cgctttccct ccatttaccg 2303821 caacaacaat ctgtctgttt ctgcgtttat ttctcattga atccctccag cgcttgtcta 2303881 gtaattactc tatgaacaag ctagaggaag tagaactgtt tagtgattgt aggagccttt 2303941 gttttcttgt gacacttttt catgaagcgc tgtgtttaat ccgttcgcta aaacatttgc 2304001 catatcgtcg ataaatgaat cgacttcctt cggtgtaacc attaagttgt gccctaaagg 2304061 cgaaagcacc tcgtgaatga gctgccgttt ttcatcttct tgaagggttc cgacaatacc 2304121 taggaacgat tggcgctgct tttgatcggg aagatcgtct tcagtgagca ctttcttttt 2304181 cccaaacgtc atgcctgccg gaacaagcga tcttgatggc ctgttatcct tcatttctct 2304241 gccaaaatgt tttaatatgt agtccaccgt gtcgctggca attgtcacgg catcaactac 2304301 tgtcggaaca ccgatagcaa tcaccggaac accaagcgtg tctttgctta aatcttttcg 2304361 tttattcccc actccagacc ccgggtgaat gcctgtatcc gatatttgaa tggttgtgtt 2304421 gaccctttcc accgcccgcg ccgccaacgc atcaatggcg atgacaaaat caggcttcga 2304481 ttgctcaatc acacctttaa taatgtcact tgtttcgatt cctgttatcc ccattacacc 2304541 cggtgcaaaa gcactgacag gcctgtaacc ctcctgtacg ttttccggct gaagcttaaa 2304601 caagtgcctt gttaccaaca gattttctac tgccatcggt ccaagcgcat caggtgtcac 2304661 gttccagttg ccgagcccaa cgatcaaaca gctcgcatct tttgagatat taaggttttc 2304721 aagaaaagct gagaattcct ccgcaaagac agcagagacc ttctcctgca tttccgaatc 2304781 attctccctg attccctgtg cttcaagcgt taaatagcgc ccttcttttt ttcccgaaag 2304841 ctctgcgcct tcctttgtaa catcaactgt gcggatttta atgccgccgt gatcacgctc 2304901 tttttcaata aagcctttaa tttcttttgt cggcacagcc tgctgattgg ccattgcttc 2304961 cttcgtttcc actgccaaat cggtccgtat caaatactga ttcacatcca gctcactctt 2305021 tttcatacag gggcctcctt cacattaagt acctatattg ttgccatttg ctgaataaat 2305081 catgctaaaa agagaacctt caatgaaaaa tactttacat ttatattgca atctaaaggt 2305141 gtgtttgata gaatacaatt tgttctattg tgaagaagat ttaaccttaa gacactgtgc 2305201 tacaggttgt atcttaggag gtgaaacaca tgccaaacat taaatcagcg attaaacgta 2305261 caaaaacaaa caacgaacgc cgcgttcata acgcgacaat caaatctgct atgcgtactg 2305321 caatcaaaca agttgaagct tctgttgcca acaacgaagc tgacaaagcg aaaactgctc 2305381 ttactgaagc agctaaacgt attgataaag cagtgaaaac aggtcttgta cacaaaaata 2305441 ccgcagctcg atacaaatca agactagcga aaaaagtgaa cggactttct gcataatata 2305501 aaaacgatcc tcaataatgg ggatcgtttt tttcatttct ttttaacagc tgtaaaagga 2305561 acagttcgag caggagctgc ttgtcctttt tcccggtttt catctcatag tccatgacgg 2305621 caagctgttc aataattaaa cggagctcct cctctgaaaa aagccttgct tgatccatcg 2305681 ccagctttac ccgaaatggg tgaactttta gattagaagc gatttgtttt tgtccgtatc 2305741 cctgttccgc gaagtacttc gtctgcagaa tcagccggaa ctgattcgaa ataagcgcca 2305801 taattttgat cggttcttca ttttgtttta gcaaatcata aaaaatttgc agactctctg 2305861 ttcgttttcg gttgacgatt ttattgatca gctcaaaaat attttgttca aggcttctag 2305921 caacaagcat ttttacatca tccagcgtaa tttcttcacg atctccaata aacgtgcaga 2305981 gcttttgaat ctcctgaaaa atcgatgaca gatgaccgtt cacaagcaga accaaatgct 2306041 ccgccgcttc cgtgccgatt gttttctgct ctgtttttgc aaggttgaca gtaaagtctg 2306101 tcgtttcctt tgcatttaat tccttcgcct ccatcataaa cgcgtgcttc tttaacgctt 2306161 tcgtcagctt ttttcgctca tcaagctttt catacggagc aagcaggaca aagactgtgt 2306221 aaggcgcagg tgattgtata tatgattcaa gcgcactgac gttgtgctca attttttctt 2306281 ttttcttttc acctgttaaa aaatatggat ttttcacaat gacaagacgc cgctccccca 2306341 taaacggaaa cgtttcagca tctgcaatcg cttgatccag cgggtcctct tccagatcaa 2306401 aaacggacag attgaaatcc tttgtctcct gatcaacgac cgtctgtctg atcctgctga 2306461 cggtttcttg cagcagatat gtctcttttc cgtataaaca ataaaccgga tggacctctc 2306521 cttttttcag gcttttccac acatcaaata ccattgttgt acgacttcct ctctttcatc 2306581 atccccttct atcctaaatt gagtttgcaa aatagtaaag aggaagcctg actgctgctt 2306641 ccccatttat attaaacgcc tgttcgcaag cccccgggac agcttgtaaa aaggcgataa 2306701 tcaccagaac agaaaacgtt accttagctt ctagattttt caaaacaatt ccattatact 2306761 taagtcagtc aggagggata aagttgaatg attttgaaaa aaacgttcaa agcaaacgaa 2306821 atgatgctgt agattcagct gttggttttg ttgtgtcctt cggatttttc gccttcttgt 2306881 ttgtcatggc aacggttatt cacctagttg gttcataaca gcgactgccc gggctgctga 2306941 tttctcggca gtctttttta gttcgtctct gttatatctg atgtatcata tggaggatag 2307001 acagaaaagg ttccaactct gtttttgtat ctatattgga tcgttccgtt ttgatctgtt 2307061 cgcagcacgc ggatagaatg tctctgtaat agttgcagaa ctttttgatg aggatgatgg 2307121 taccgattgt ttttcccggc tgagataatg gccgttttcg gctgaagctg ttggatgaat 2307181 tcttcaccgg tagagccttt gctcccatgg tgccccacct ttaacacatc tgcttttata 2307241 ttcggaaaca cgttcatcac ctcttgttcc ccttctttct ccagatcacc cgtcaagatc 2307301 cagctcatac cgcccgtctc catccacaga acgagagatg aattattttt gcttgccgga 2307361 tcaggtgctt ccggtgacag tacatggaac tgcaaatcct ttatttgcaa cacatcgcct 2307421 cgcttcacct cttcaattgc cactccctct tccctggctg cctgcagcac tttctcatct 2307481 ttaggttcag aaacgaaccc tttcggaatc acgaggcgct ttactttatg atgcttcagc 2307541 agaatctccg cctctccgat atgatcttgg tcagcgtgcg tcagaattaa agcgtcaagc 2307601 tgcttgattc ccttagcagt taaaaacgga atcagcacct tttcccccag tgaaaacgga 2307661 tgctgttttt cgcgccaagg ctctgacgag taagacaaag tgccgccggt atcaattaag 2307721 acacgacccc gctgatgcgg agcacctaca aacatgctgt caccctgtcc aatatctatc 2307781 atatccactt ctccttcgga actaagacac ggatatataa agagcagaaa catcaccgtg 2307841 cagcaaatgc ctccggttac catcaactgc gacaaggagc gtttttcaat cgccataagc 2307901 aataggatga tcgtgactgt gaataaaaaa agcaaaacag gtgcaggatg tgcgatcata 2307961 atcgtgaaca catcaacatc tgcaatgttt gtgattaacc tattgatcca gcttatcaat 2308021 aaatcaaacc agctgaaaaa caatctccca aacgaagcgg aaagacttaa tagaagaaca 2308081 cctgctacag ctcccggcaa aatacagaag gtataaaatg gtaccatcaa catattcatc 2308141 ggtacgctga tgatagaaaa ctgatgaaaa tgatatagga gaatcggaag cgagcccagc 2308201 tgagcgatga gtgatacaat tgtcagctgc cccaaggagg ttttaacctg ctgaaaaata 2308261 gaagaggata gaattaaaga aaaactgacg gcgaacgata gctgaaaacc ggcttcaaag 2308321 agatgataag gattgaagag cagaaggacg atgtacgaaa ggcaaattgc agttgcagag 2308381 cggacacgcc atttgacaag acttccagct aagtaaacac ccgacatgag agcggcgcgt 2308441 agcactgaag gagcagcgcc ggtcaacatc acatagagcg gcagaaataa cagcaacaga 2308501 attgacgcct tttctctagt tataccaagg cggatcatga tataaaacaa acctgctgtc 2308561 aaaatcccca cgtggagtcc tgatattgcc aagagatgga caacaccaag cttttgatac 2308621 gcggtaagca cttcatcctc cacgtaaaat ctgtcaccaa ctgtaagtgc ctgtacaatc 2308681 cctgtcgaat caggaggcag aaggctgttt gtgaatgata tgatatgttt tctcaagctg 2308741 agcaccttgt acttgaaatt ttcaggttcg ctgcagtttt ggatagacgt gacagagtag 2308801 ttccaatgaa tatgctgccg ataaagatac tcgttataat caaatgcacc cggcacagtt 2308861 gcgtgattcg gttcttccaa tgtaccagtc aactcacatg acattcctgg ttctatgtat 2308921 aacagctgtt ctttttcacc agcagactga atgcgatacg cagcagccca tttttcctta 2308981 tcaggtgtct caaccatcat agacatacgg tcgccgtcaa ttttgggaat agtgtcaatc 2309041 actgccttga attgataggt tccctgccga taggaagaga cattctgaga atctgtgact 2309101 gcatacagta caaaaaacaa tataaaagag aagaaacaaa caataataag aaaagcgtgc 2309161 ctcgttttga ttaaaatgat gaggagaaag aggatgaaaa gaaaaatagc ggggaaataa 2309221 gcggcggcag taattccagc cgttgccgaa gctgccgcca taggcaataa taagcgcgaa 2309281 ttacgcattc atcacacgta gctcgtgaaa agtgtattcg cctgttcatg tatctttttc 2309341 aattcttcct ccgctaaacc ggcatcagcc aatttcccta ttagacccgc tacaaatgaa 2309401 agcttttctc tgtttttcag atcaacgatc atttcatcga gttcaacctg ttcaacagtt 2309461 acacccgcct gttcaaataa ttcctgcgca tacggatgtg ttttgtaatc ctcagcataa 2309521 taaaccgttt tgataccagc ttgaataata gatttgcagc attgaatgca cggataatgc 2309581 gtcacataaa tctcggctcc atcagtcggc accccaaact tagagcattg aagaatcgca 2309641 ttcatttcag cgtgaatggt tcttgcgcaa tgatcatcta tcattaagca tccttcatct 2309701 gcacaatgta cgccgcccgc gattgaccca ttgtagcctc ctgctatcat gcgtttgtct 2309761 ctgactatag tagcgccgac agataatctc ggacatgtgc tgcgcagcgc caataaatgg 2309821 ctttgagcca taaagtattg attccatgaa attcgttcca cgttgttccc tccaaatgtt 2309881 gtgttgcctg acctttagtt tacctatcat aatgcatgac cgtcaaatca ctttactgta 2309941 atggaagact ttattttctc aaatgacttt tcacctattc ctgaaacctt agtgatatct 2310001 tcaattgttt ggaaacgacc gttttcctcc cggtatgcaa taatagcttc agctttggat 2310061 ggccccaccc ctgagatgcc ttgtaactcc tctaaggttg ctgtattgat attcaccagc 2310121 gctcccttcc ctccatcgct ttggacagac cctccgccac cttgctgcac tgctgtttcc 2310181 tctccctttt tcgggatgta caccactgtc ccgtcctgca gaatctccgc caaatttact 2310241 tgcgcttcgt ctgcttgttc actggtcccg cccgctttct caattgcctg agatactctg 2310301 tcccctgttc gcatttcata aacgccagga tgctgaacag cacctttgat gtctatcaca 2310361 attgtttcgt ttgactcgtc gttgtttgct tcctgcttta ccactgtatt ttctgtctct 2310421 gttggtacag cttgcttcac cggctcttta tttttccctg tggccagaaa gatcataatc 2310481 gctgtgaaaa cagccgcaga agccgctaaa ataattgctt tcttatgctg attcaaccaa 2310541 ttcatcgtgc atgttccccg ctttcgtcat attttatttt cataacacat atggtttaga 2310601 ggataatagc tcaaaggagg ggaaaccatt gaagataggc tttatcggca caggaaatat 2310661 gggtacgatc cttatcgaat catttattga atcaaaagcg gccgatccct caaacatgac 2310721 aatcacaaac cgcacaattg aaaaagcgtt gcacataaaa aaccgctaca acagcataaa 2310781 cgttaccgaa agtctcgaaa agctcgtttc tgaaaacgag atgattttta tttgtgttaa 2310841 gccgcttgat atatatcctt tactggcaag agcgttacct tatttaagaa aagatcatat 2310901 tctcatttca attacaagcc ccgttcaaac cgaacagctc gaacaatatg tgccgtgtca 2310961 agtggcgcga gtgatcccaa gtattacgaa cagagcgctg gcaggtgttt ctctcgtcac 2311021 tttcggcaca agctgcggcg aatctgcaaa agcgaaaatc aatgagctga tgcagcatat 2311081 ctctcatccg ctgcaaattg aaagtgacat cacgagggtt gcatcagaca tcgtaagctg 2311141 cggccccgct tttatgagct atctgattca gcggtttata gatgcagctg tttcggaaac 2311201 atcagtgtct aaacaggacg cgattttgat gtgtaaggaa atgcttgtcg gaatgggaaa 2311261 actgttagaa accgaattgt ataccctgcc tgcattacag gaaaaggttt gcgttaaagg 2311321 cggtgtaaca ggagaaggca ttaaagcgct ggaaagcggt gtgcaggata tgtttcaccg 2311381 ggtatttcaa aatactcata tgaagtacga ggaggatatt tccgcagtga aaaagcagtt 2311441 tcatgtgtag acgagtatgt catacgttcg tctgtactgc aaaagcataa aaaagcattt 2311501 taaaaaacca tcgttttagg aaacgatggt ttttgatttc tgcgccttga aaaagaggcg 2311561 ttctgattgt gctgatggct cggtatccgt aaaatcagct gtcacgcgat ggagctgaaa 2311621 gccgcagttc ttaagcattt cttcgtattc ttccaccggg aacgttcttt gctcgtgtgt 2311681 ctcatcaaaa cgatcatacg cttctccgtt ccacacaaaa aacgacatat catgaatgac 2311741 agaaagctcg tcacttccgg caaagctctg ccaaatatag ctgatatctt cgtcctggtc 2311801 agcaaatgtg ctatccggaa agacttccgc aattttaaaa gatgaatgaa catcaaacag 2311861 caggatgcct tcaggcttta atacccgaaa aacactttta aaggtttcga tcacatcatt 2311921 ttttgttttt aaataattta atgagtcaca gcatatcaca acagcgtcaa attgaccgtc 2311981 aaagccggta atctctctca tatcctgctg aagaaataaa ataggctggc tactcgatac 2312041 cttttgctgg gcgaaagaaa gcatctcttc gctgagatcg atgcctgtaa cctcgaagcc 2312101 tttttcggca agccggatgg agatttcccc cgtgccgcat gccagatcga gaatacggcc 2312161 tttttccggg agagatgctt caatccattt tgtccattga tcgtaaggcg cgtgtgacat 2312221 tagctcgtca tacacgcttg caaagccttg ataaatcatt gattcattcc aaagtcaaga 2312281 tctgcgagcg gagcgtctcc ccacagcttt tcaaggttgt agtagcttct ttcatccttg 2312341 tggaagacat ggacaactac atcgcctaga tcaacgagaa cccatcttgc ttcatcaaag 2312401 ccttccatct ttttgacttg aatgccgttt tcatcagctt gatccttgat ttcacgggca 2312461 atcgcctgta cctgtttatc tgaatttccg tggcagatca gaaaataatc agcaaccaga 2312521 gaaatacctt ccatatccag tgctaaaata tcctctgccc gtttatcatc gcaagccgca 2312581 gctgcgatct ttaaaatgga cttttggttc attcacaaat tcctcctgtt cagctgccag 2312641 acacaagcca gttatacgtt aaaaatgtgt ctggaaaaac cggttgattt tttttcataa 2312701 gaaaaaccat tgtattttta atggactgaa tcagcgcttg attcaaatct gtctcagcaa 2312761 gcttacgcac ctcatcgaca ccgggaaatg cccggtttgg ctcaatgtaa tcggcaacgt 2312821 aaatgacttt ttctaaaagt gtcatgccgg ggcggcctga ggtatgatac ctaatggcgt 2312881 caagaatgtc ttcatcttga acccctgcct ctctttggac caaataagcg ccgaccggag 2312941 cgtgccagag ctccggatta tgatccaata aatgcgcagg cattttttca cgcgcaataa 2313001 tttgtttcat ttcttctttc gggcggaatt tggcgtaatc atgaaagatt gccgctattt 2313061 ccgctttttt agaatcggct ccaaaacgct ccgcaagttc gatcgccgtg ttcatcacgc 2313121 caaccgtatg gatatatcgg tgttcggtca attgctgctt cacgcatgca agtgcctcct 2313181 cacgattcat ataaaccatt ctcctctaca tacttcttca ctttatcagg gattaagtag 2313241 tcagtgggct tcttgctttt aaaccgttcc cttatcatag ttgatgatac ctcaaattcc 2313301 ggaacgtctg caaagagaag cggataaggg gtttcaacat gaaaaccggg gcgctttact 2313361 ccaataaatt gaatgaggtt cagcagctcg tccagcttat accatttcgg caaatattca 2313421 atcatatcag cgccgataat aaagaacagc tgatcatttg gataacgctg cttcagtaaa 2313481 gaaacggtat caaaggtata tgatggccct tctctttcca tttcaacaag ctccagctta 2313541 aaggacggat tagattgaat tgcaagcttt agcatttcca cgcgatgaaa gctgtcggta 2313601 tagtcttcgt tctgtttatg cggcggaatt tgattaggca taaaccaaat ttcatcaagc 2313661 cccgcctggt acagcacctc attcgccatt aagaggtgac cattatgcgg agggtcaaac 2313721 gtgcctccga aaattccgat tttcttcatt tcaaccacct ttaaggaagc tcgatttgtt 2313781 tattttcctt tgattcctta tataacacaa tcgtattgcc gattgtctgc accaattgag 2313841 agcggcttcc ttttacaaga gcttccgcta catcgttttt atcctcttcg caattctgaa 2313901 gcacgctgac tttaatcagc tctctcgctt caagcgcctc agcaatttgt ttaatcatgt 2313961 tgtcgtttac tccgccttta cctacttgaa aaatcggcgt taaatgatgc gcttttgaac 2314021 gcaaaaaacg tttttgttta cctgttaaca ttctgttcct cctaattttc ctattacaat 2314081 agatctcatt ttttcaatat taggctcttg tccagtccac aattggaaag acaatgctgc 2314141 ctgttcaaca aacatgccca caccatcgag tgttttcaag cctttttggc ttgcttcttt 2314201 taaaagtgcc gtctgtattg gattatacac gatatcacat acgacggcac tgctcgcggc 2314261 acgctgtaat gaaagcggca catcgtccac gttcggatac atgcccacag acgttgtatg 2314321 gatgataaca tcatactgct caagacgttc ttctgcttct tttatgctta atacttcttt 2314381 attgtgaaac gagggagtag cttctgtaag ccgctttgct ttttctaacg tccggttgca 2314441 aatgtcaaat tttttcgggg tatttcggac aattgttgta aaaatggctc tcgccgctcc 2314501 gccagcgccg atcattaaga atgacagttc agagatgggc ttgtctaata ccttcattaa 2314561 tgacttcacg aagccttccc catcggtatt gtatccgaca agcttatctc cctctcttct 2314621 gaccgtgttt acggcaccga gcacttttgc actctcatca atatgatcca aataatccat 2314681 aatggaaacc ttgtgcggaa cagtcacatt gattccttgt acgcctagag ctcttattcc 2314741 ttttaccgca tcctccagat cattctcttc taccttgaag gcatgataat gtccgtcaag 2314801 cccgaggtct ttcaatgatg cgttatgaat atcaggtgac atagaatggc caataggatt 2314861 tccgataacc ccgtacagct ttttcataca cctctcccct tttcttaaat taatgaacgc 2314921 cgaacaaata catgaacgcc ttttggcgcg tatgcagtta cctttttatc agcgtcatgg 2314981 acagtaaccc agcctaaccc agagaaaacg atatctgtct ttttgtcttt tatcgtaaac 2315041 gtatgggcga ccaattcagg aaactcatcc atttcatctt tacccggagg tgtgagcaat 2315101 tcccctgcat gcttttcata aagcgcgtct gcattttcaa gttttgttct atgaatcatc 2315161 agctcattcg gcatatagca aataaaagga gatctttccc cagacacata atcaaacctt 2315221 gcaagtccgc caaaatacag tgtttgctga tcattaagct ggaatgtgcg aggcttcagc 2315281 tcctttttag gagataatat tttcaggtcc tttttattga cataatgcgc catttgatgg 2315341 ttgttgataa ttcccggtgt atcataaagc gatgaaccgt catccagcgg gatttcaatc 2315401 gcatcaaggg ttgtgccagg aaattgggat gttgtaataa tatcttcttc acctgacact 2315461 tctttaataa tccggttaat aaaggttgac tttcctacat ttgtacatcc gacaacatag 2315521 acgtcttttc cgttgcggta atgctcaatc gcgtcaatta cttctctgat tccctggccg 2315581 cgacccgcac tgaccaaaaa tacgtcaacc ggttttaagc caagctcttt cgcttcacgc 2315641 ttcatccatt ggatcagacg ctctcttttc agtgacttag gcaaaatatc cgctttattg 2315701 ccaactaata agatagggtt tccccccacc aagcgctgca gcccattaat ccagctgccg 2315761 ttaaaatcaa aaatatcaac aatttttacg accagagagt ccgtttctcc aataccgtga 2315821 agaatgttca aaaaatcatc atcagttaag gagacatctt gtatttcatt atagtttttc 2315881 agtctgaagc aacgctggca aatcacattt tctttcgtaa gcgatgcagg cggcgcgtac 2315941 cccaaacctg ttttgtcctc ggtttggatc gtaactccgc acccgataca aacaaccttt 2316001 tccatttctt actcctccca ctgaatgtgc ccttttcgtt tgagagcact cagtattctg 2316061 cgttcgacct ggcggttaaa gcgcgtaatg aatccgtcag aggaagcgac tggcacgacc 2316121 aaaatcgtat ggtagccgtt tcggtttccc ccgagtacat cggtcagcag ctggtctccg 2316181 atgacaacgc agtcctcttt tttcagctcc atattgcgca ccgctctatt aaaggcttta 2316241 cccatcggtt ttcttgcttt atagatgaat gggattccaa gcggttctga gaaaagtttc 2316301 actcttcttt cgttattatt agagacaatt gtcactttaa tgccgtgttc cttcatttct 2316361 tcaaaccact cgatcaatcg cggcgtcgcg ttcggcctgt cccattcaac aagcgtatta 2316421 tccaggtcag taataattcc ttttacattt cgttccttta atttctcagg tgtaatatga 2316481 aaaatatttt ttacaaactc gtcaggtaaa aaaaactttt ttaacaaaac ccgcaccctt 2316541 ccctttttct ttctttcaaa atgattgtcg aaaaaaatcg aacttgcgcc taaagaaaaa 2316601 ctgagcaaaa aaatttcgac aaaaattggg tttcttcacc aggtgtggat aaatttacac 2316661 acactatcca ctcttattac atcactcttt agacaaatta taaacacgat actcacaagt 2316721 tatccacttt ttggtgtgga taacagaacg attgttctta tatgcatttc atggtagatt 2316781 aaagataact tcaacctcag atgaatgcaa cttatcattg tatgcgttaa aatcatgaat 2316841 gattccaact tttaaggagg tgcctctccc attaattggg ttcctagcat gagaaaactg 2316901 tctgatgaat tactaataga atcttatttc aaagccaccg aaatgaattt aaaccgtgac 2316961 tttattgagt taattgaaaa cgaaataaaa agaagatcgc tcggacatat tatttccgta 2317021 tcttcttaat aggaatttgt ctattttttc cgggcgtatt tccttttttt actcagatga 2317081 ctgatattat atcactttgg ctgcgcgctt tactactatt ttcagcaaaa aacaccccta 2317141 aaaagaggtg ttttaaaggg ccggttatta tgctaaccag tatatgccgc ccacaacaag 2317201 gagaacaaca actaaaacaa caataaaagc gtatccatat gctctgcctg cgccatacat 2317261 gtgaagcgcc tccttaataa ggttttataa cagcctatgt aggagaaata aatcggacta 2317321 ggcggttgtc cggctcaacg ctgcaggatc tgcccatctt gtattccttc atatacgatc 2317381 cttgcccctt taggtgtcat atgatttcca gaaggatcta taagaccaga ttggataagc 2317441 gcttcatcag ttgcttttcc gccgtctgct tctataaaat gcttccagtt atctacaaga 2317501 gggacatcca ggcgcttcga cacatctctt gtaatatcgt tatatgagtt gtgccatttc 2317561 cttgctccgc cttttggttc aaaagcagct gcttgatatc tggaatagta aaacaaatga 2317621 tgcttcccat taccttctat aattgggata cacgtcatta agattggctt gatcccgtgt 2317681 tttctgcttt cttcaataaa ataaaccaga ttttctctaa aacgctgctt cgacactctc 2317741 ggtttcccct cagtcagtat ggcagcgtca ttggttccga acataataaa caaatacttc 2317801 ggtttttgat ccagcacatc tgtctgaaat cggagacggg catcctctgt cgtctgtccg 2317861 ccgattcccg cattgagtat atcaaggtta ccgcgctcag ctgtttttaa tatattgacc 2317921 cactgctgtg cttttggata atcgcgataa tcccaattag agccacgcgt attactgtca 2317981 ccaaatgcta caacgtcttc gtatcccctt ccctcgcatc ctgctgtaac gaacagcaga 2318041 aggaaaagga tgataaaatg tttcatcttt acacccccaa aagcctcact ttaatgttat 2318101 acctctgttt ctcttcgttc aatgaagagt ttttcgctat cactgttttt tcctatagtt 2318161 aacgtgtccc cctcagtgaa tatcattctg ctttcattgc ggcgcagctg atgatttttt 2318221 aaaattccct tctttccaat ctgaaaaaca cacaaaccaa agaaaagaaa ataacctgaa 2318281 tccgcactgg aaacaggtta tccgttaaat cctgcattta ctttaacttc gatttaagct 2318341 tggcctttgt ttttggccca taaatcccgt ctgcagttaa tccgttcatg agttgaaaac 2318401 gcttgacggc attcgctgtt ttcggtccgt aaactccatc tatgccattg tttttggctc 2318461 ccttatcagg gtaaaagtga agtacagcta aagccttttg cagctggaga atgtttgtgc 2318521 cctttcgata aggcgaagtg agctttataa ccccagacgg cagaggatat gatggtgaag 2318581 tttcttttgg aggtgtatcc gaggaagaaa ttccgtttag aaaagagttc cagtggtcca 2318641 agagtttccg cggacattct ttcccggacc actttttgtg gggaacaaca cgatttaacg 2318701 gaatattgtt ttccttcatc agctttctga tcagccactg ggcatttgat gttgcttttt 2318761 caaaatcgcc gtcagcattt tcacagattt caatcccgat cgatttgcgg tttcctgtcc 2318821 cgtttgtacc gtctcccgca tgccagccgt tttcatctat cgggagatgc tgataaatga 2318881 ctgaatcgtc aactgtaaaa tgccagcttt cggatgtgtt cgggtttttc acaaacttgg 2318941 cgtgcatttt cgcatcagcg cctttggctg tattcgctgt attatgcacc gtaatataag 2319001 caggcgccat cgcatagcca ggacgattat catttgatac cggtataaaa tcctttttta 2319061 tggttaccat ttctatccct ccctattaat aagaatgcag aaaacagaga gatggacagc 2319121 cttttttatg aggtaaaaaa gaattgtgtt cttaacctgg ttttcagttg aacagctgaa 2319181 atggcaccag ttatactaat ttagatgacg gaggttttga ctcctgacat cacctaagtt 2319241 gggagtgacc atagacatgt taaaaaaagt aataggtata cttgtgatta tcgctatcat 2319301 ttcagttggt ttttttcaga aagaagcttg gcttgatgca atcaaagcag gagggatgtt 2319361 ttccgtttta tttagtatgc tgctgattgc tgccgatgtt tttttcccaa tagtgccgtt 2319421 tgctttgatt gctgctttaa atggcgcagt gttcgggact gcaaatggaa tttggattac 2319481 actgaccggc tcaatgcttg gtacaatatt gctgtttttt ctcgccaggt acagttttag 2319541 agattgggcc agaaaaaaag ttcaggccta tcctgccata caaagctacg aggcttcctt 2319601 caacaaaaac gcttttaccg ctgttttatt aggaaggctg atacctgtca taccttcact 2319661 tgtaatgaac gtgatctgcg ggctgagcca ggttcgctgg catgtttttt tctttgcgtc 2319721 tttaataggg aaaatcccca atattgttgt tgtcactatt gcaggtgcca atttcaccag 2319781 caataaatta ttgtctatca gcatttacgg tacatatatt ctgatcatca tgctggtcat 2319841 ttataaaaag ttccctcatc ttctgaaggt gccaaaaaaa taaggaggct tgttggcccc 2319901 cttacttttt ttctgtcgca tggcctccaa attcatttcg aagcgcagca accacctttc 2319961 ctgtaaacgt atcgtctgtt aaagaacggt atctcatcat tagtgacatg gcgatgaccg 2320021 gcgttgccgt ctgcagatca agcgcggttt ccaccgtcca ttttccttca cctgaggaat 2320081 gcataatgcc cttgatctga tccagtttcg catccttagc gaaagctcgc tcagtcagtc 2320141 ccataagcca agaacgaatg acagaaccat gattccacac tctggcaacc ttctcgtagt 2320201 caaaatcaaa ttggctgttt tcaagcactt cgaatccttc accaatcgcg gccatcattc 2320261 catactcaat tccattatgg atcattttta aaaaatgtcc gcttcccgct tcaccagcgt 2320321 atagataacc attttcgacg gcagtatcac gaaaaagcgg ttccacaatc tcccatgctt 2320381 catgatcgcc ccccaccata aaacaggctc catgccgtgc gccttccatt ccgcccgacg 2320441 ttccggcatc gagataatgg atacccgctt ctttcatttg attgtagcgg cgaattgatt 2320501 ctttataatg agagtttcca gcttcgataa tcatatcgcc tttacttaat aaaggtgata 2320561 catcacgcaa aacagcatcg acaatgccat gcggtaccat aacccatagg atgcgcggcg 2320621 ggtgtaataa agaaatgaac tctttaagat ttgttgtccc ctcagccccg tatgctttca 2320681 gttcatcaac agccgcttga tttacatcat atccaaccac ttgatgattg cggtcaatga 2320741 attgctttcc tatgtttatg cccattttcc ctaagccgat taatccgatt ttcatatctg 2320801 ttcctcctga ttgtctaaaa agcctttact ctttatgttc cctatggatt gtattgtgat 2320861 acgcagaaaa caaatggggc ttacatcgtc tgcgcatgta aattttattt ttcatgaccg 2320921 acggcgcctg ccagttctat tactgaatct ctttatatcc ataattatcg ctttatcctt 2320981 gatttaccat cagtttaagt taaaatatgg gaaggaattc gattttttca gtaaaaagaa 2321041 ggtgacatgt tgcagaatca atctcatact cttattggag ttacgaaaac cgctgtattc 2321101 tttttatacg ctgcacttgc aatcatcggt tttgcaatcg ggtattttat tccgcagatt 2321161 gcgaaatggg cattatccct cccctggatc cctcttgaag gaccacttcg gctcattacc 2321221 tcttttcagg gatctacagc ttcatttatc actgctcttc tcggtatgtg tgcggggatt 2321281 tggttcgctc attctgttat tgcaatgctg ctgtctgtca aaattacaga tcacacagtg 2321341 gaattcatca aaggaaaaaa agtgcaaaca attcattccg atgacatcgc tcttgtattt 2321401 atggatcaca aacggcttgt cctcctggga acagccggat atgaattggt acgggaagaa 2321461 attgatgaaa aaccagtaaa cgttgagaag gcctttagac agcatcatta cgaatgggca 2321521 acagatggtg atccgtttaa agatcaattt cgccgatgga ttcctgatgc accagaccta 2321581 tcgcaaggcg cccatgcctt attaaaagct cgtcacaaag cactgcagga cgaagaaaaa 2321641 gacgatattg aagaattccg tctcgaactg gcacagctgg gcatcgttgt acgggacgaa 2321701 ggcacacgcc aatattggcg aaaagcagaa acctatcccc cgaaaattca gctcggcgaa 2321761 ggattgtaac aacagaggct caagaaagag cctcttcttt actactgcac aataaacagc 2321821 actctggtac cgtcaggata gctgctcatt tgattcccta cccacgagcc ggcgccgcga 2321881 ttatcagaag gcgtcacata tcggacatca gcccctgcac cgccttcctc gcagaccgcc 2321941 atcggccact catcccggtc atagcccggc ttggtcggga ttccctttaa agattcctcc 2322001 cgccttttgt ctgctccatc tctgtcaatg gtacaaatat ctggatgtcc ctctgcaatc 2322061 gcatccctaa tatgactgcc ggtttccgga taacgagaca gcggaaaata taacactttg 2322121 tcatacgaag atgcgccttg gatctgttgc ggaaccatta aacaaagaag aactgctgca 2322181 gcaagaaaca ggcctgccat ccattttttc atccccatcc ccccatacct ttgttcattt 2322241 caatgtatgg gcgcttgatg aagaatattt ttaacatttg aagttagtat gctgcttacc 2322301 aaagccggac tcccccgcga gaaatttccc ggtacagaca cagacagcct cccggtcaca 2322361 tacatttaca tataggcttt tgcctacata cttttgtgga ggtgacgatg gtgacaggtg 2322421 ttttcgcagc gctcggcttt gttgttaaag agcttgtctt tttagtatct tacgtgaaaa 2322481 acaatgcctt tccacaaccg ctctcaagca gcgaagaaaa aaaatactta gagctcatgg 2322541 ctaaagggga tgaacatgcc agaaacatgc tgattgagca taatcttcgc ttggtcgccc 2322601 atattgtgaa aaagttcgaa aatacaggtg aggatgcaga ggacttaatc tccatcggaa 2322661 cgatcgggct tattaaagga attgaaagct attccgctgg aaaagggaca aagctggcga 2322721 cgtatgcagc gaggtgtatt gaaaatgaga ttgtaattac aaaagggggg tgcatacacc 2322781 cctctttaat acgtttcaat atatatggtg tcagaatcca caatggtaac ttctttcacg 2322841 ataaagttaa caattgtttt tttatcttca agagttaagt tatctgcacc gattgattga 2322901 aaatagtcga tggctctttt tagagcattt tcacttgagc tcgtatcatc taggactttc 2322961 atttttgact ggatttcgtt acacttttca gtaagctgat tttgcttttt ttgcagttca 2323021 ataatttgtg ctttgatttc atctatgtct aaatcatcgt catcgcttag gctgattagc 2323081 gttaaaagac gcttgcggcc tttttttgtt ttctctatct ctttttcaat aagttctaat 2323141 tcatcagaca ggtgatttga ttgttcagcc tctttaaaag aaacatactt ttgaggattt 2323201 gtgatgaatt taaaaatttc accccataca tgccggttca atttattctc agacatttct 2323261 tttccgcagc cgcggtcctt tgcgccagaa taatttttcc ggcaagtata tacatagtag 2323321 tctttaccat gtgattttct tttcttccct gtcatggtat ttccgcattt tccgcatcta 2323381 accaaacccg ataacaagta attgtgaggg ctgatactca agtgttttct tttactttga 2323441 cctaagagtt cttgagcata atcccattgt tcagctggaa caattgctgg aattgtcaca 2323501 gtgatttgtt cttcttcagg ccttatttta attatagatt tgttccctgc ctgctttgaa 2323561 acataggaac cctctgtatc atatttatac tgtctatgtt cacccttata ggaagagttc 2323621 attaatattt gccgaacaac ctgcctgtgc catactttgg cgcctttttt tgttttaacc 2323681 cccatctgag ttaaatgtag agcaatacca tttactctgc cgaaaaaagg gcttttatga 2323741 tcggtgaaat agttaaaaat catccgaatg atttttgctt cctcttctaa tatctcaaga 2323801 gttcttttct ctttaacaaa tttatagcca tatagtttag aatctttaat gatcatgcct 2323861 tttttcattt tttgaagtcg gccgcttgat gtccgttctt tgattttggc tttttcaaat 2323921 tctgagattg ccccgcgcat tgcgaaaaac aattgacctt ctggagaatt ggcgtattca 2323981 ccatttacaa aaatcaaagg tatgtttcgc tttcgcaatt cgtcatcaat gattagctga 2324041 ttcattaatt tccgagaaag acggtcagga tcgtaacaaa tgacttgact tataagtccc 2324101 ttgcttgcat cctccctcaa gcgattcaaa gccggacgtt ctaaaagctc tcctgaaaat 2324161 ccttcatctg catacttcag cacatcttta gtccctgctt tctttataca ggcctcgatt 2324221 tggctgtcga tgctcgatcc cttgatcgct tgttcctcgg tcgataccct tacatatatt 2324281 gctatcaccc tgaatctcct tcctataaag ttttattaaa taatgatagc aatcgttaat 2324341 gcatttgtca gcttgcggtc cctcgatgat tatcactttc ataaaatgca tcaccccttg 2324401 ggtaatgcta tgtaacagct gtttgtccaa atgaggagat tttaaattaa actatagtgt 2324461 tattaaacgt ttcaatgaat atgcaaaaaa tttaaaaaaa gttgttgtga cttttctaca 2324521 ctcctttagg tcctcaatag aaaagatttt attttctatg cctcaacatt cgcttattat 2324581 agttttcaat gatttattat tatttgagag tacaatggag tagtgttttt cattgttaga 2324641 tagttaatga catttcactg gtgtcaagtt cgtatagcta gacattaata aaaaaaggac 2324701 acatataaat atgcatcctt taacaaaaga gtttatttat ttccctgttt cagcaaattc 2324761 cttcaaccta ttccctattt catcacgaac tctttggaaa aacgcccatt tttcttcttc 2324821 tgtcccttgt gctcttgccg gatcatcaaa accccaatgc tcacgtttta catgtggagg 2324881 cgtcatcggg catttatcag cagcatctcc acaaagcgta acaactaaat cagcattgtt 2324941 cagaatatca gaatcgatta tatctgacgt ttgattagag atatctatac caacttcctt 2325001 catcgcttta acagcattcg gatttaatcc atgtgcttct atccccgcgc tatacacttt 2325061 ccactcatca cctaaatatt gtttagccca tccttcagcc atttggctcc ggcaagagtt 2325121 ccctgtacat aaaaagtaaa tgattttatt ctccatatat tccacctcta catcgagtga 2325181 cttccaaagt attttcgttg aaaccataaa gcaaccttaa caagtgctat catgactggc 2325241 acttctacaa gcggaccaat tacggcggca aatgctgcac ccgaatgaat tcgatatcaa 2325301 gcttcgcact taaacacagc ggaatttata atatatgctt ggacagccgt aaaagccgaa 2325361 ctgaacaatg gtatgatttt gctcatgaat tttgccatat atatagacat gaaggcgata 2325421 aaaaaacaat gcctgcaact tggactgatt atttggattg gcagtccaat tattttacat 2325481 atcacttttg cattccaact tgcatgttgc gtaatatcaa ccttccgtac atacaatcac 2325541 atgcaattga aaatgtagct tggttattta aggtatcccc ttcattcgct aagaaacgtt 2325601 taagcattta ttacaggaaa ctgactcaac atttatttag tcaaactgtt acgggaaatt 2325661 tatgcccccc ctttttgtaa tgaataatga aatcctcatg catttgcgcg cattgaaaaa 2325721 aacaaaaaaa gacgtctccc ttcacgatcc gatcgggcag gataaggaag ggaatgaaat 2325781 aagcctgatt gacgttttga aatcagaaaa cgaagacgtg atagatacga tccagctcaa 2325841 tatggagctt gaaaaagtga aacaatacat tgacatttta gatgaccgtg agaaggaagt 2325901 gattgtcggg cggtttggac ttgatttgaa gaaggaaaaa acgcagcgag agattgccaa 2325961 agaactcggt atctcacgca gctatgtatc gcggattgaa aagcgggcgc tgatgaagat 2326021 gtttcatgag ttttatcggg cagagaagga aaagcggaag aaggcgaagg ggaaataatg 2326081 cagaagaagc cggatctcat actccggctt tctctatttg aaagagttat gaaaatcatt 2326141 tttttcatcg ctgataagct ctccgagaaa gacaggcagg atcgtaacaa ataacttgac 2326201 ttataatcct cccgcaggca ttcaaagccg gacgttctaa aagctctcct gagaaaatcc 2326261 ttagatcggt atacttcagt acatctttag tccctgcttt ctttatacag gcctcgatct 2326321 ggctgtcgat gctcgatccc ttgatcgctt gttccacgat atattgctat caccctggat 2326381 ctcctgccta taaagtttta ttaaataatg atagcaatcg ttcatgcatt tgtcagtttg 2326441 cagtccctcg atgattatta ccttcataaa atacatcacc ccttgggtaa tgctgcgtaa 2326501 tacctgtttg tcctaatgag gtgattttca atgagtatga aaacaaataa aaaaaccgat 2326561 ggtttgtacc atcgatctgt tttctatatc actaggccct caatatagta aatctagctc 2326621 attggttatg aaagcttatt ttcattacac actatatatt catttgttat catttctata 2326681 cgtttatatc aattatggta aaaaatggtt acaaaaaccc aataaacgtc caacctaact 2326741 ttttcatctt atttattaag aattttaacc tcttccttgt gaaataaaga agcgattttc 2326801 atctccaaac agttaatgct atttcatcgg gacatgtctg ttaaagtagc caataaatac 2326861 attcggatat ccacttacaa ccacgattca atttgatcca ctacagattt ctgagctgac 2326921 attaaacaga tagagttata aaaatctgta ccagttccct ttcacaatta ggacatttcg 2326981 gcggcgtttc ggcataatgc gaactaattt attaatgttc aacaacagaa tttcgtctat 2327041 tggcaataaa gaatccacaa atcattgcaa gaatggccat cgcccaccag aacgttgaga 2327101 tcgcctgatc atgatcgatg ataatcaaac gaatgacagc tgtgatgcca atataaatga 2327161 agtagcgaag cggaaaatga aagtctgatt tgaagtattt gataatcaaa gcaatgaact 2327221 caaagtacat gaagaatata agcagttctc caagcatctc ataatagctg tccactttgt 2327281 tgaacagtga cttgtatacg aatagcacaa tgtaccaagt ctcgctgatc agaagtgcgc 2327341 ttaaggctaa cgccagaaag aacagacaga cgttgagaag cgcttgtaac aggtaaggca 2327401 cctttttgaa tttgttagaa aatctcatca tgttgtctcc tatttcaata tattcgtggt 2327461 ttttattctc agcctacatc ttggtgttcc aaaatcgtag cacaatgtag tacttagaat 2327521 tcttttgtat actgtgaaac tgtccctgca tgcgggacat cattcgcgca atgcttcttt 2327581 caccgagtcc gttgctttcc ggtgttatat ctgcaagttt aatcgtattg ctaacatgga 2327641 tctcaaatat ctcttgatcc gatacaaacg tgatactgat tttttcttcc ggatctgcgt 2327701 atttcaataa gtttgacatc acattatcaa atacacgacc aagctcctcc aaattcacgt 2327761 taatataggt ttccggcagc tcgcctgaaa tatggacccg aaaatgctcc tgatgaagga 2327821 tagcaatctg atctgatatt agatcgtaga tcacttcttt cactgcaacg gtctccagat 2327881 cggcctcata ttccttgttc agcaggaaat acgcaaacag attgtcagac aagcttttta 2327941 attgcagtgc tttaccataa gcattggcta cataccgatc tttgctggca cccgcttcgc 2328001 ctccctcttt tttggcaaac tccagattca tgatcagcga cgtcagcggt gtgcgcatat 2328061 cgtgcgacat ttcggtaacc aggctgcggc tctcagcttg caattcctcg atagctttaa 2328121 gtttatccag gaaagctttc cgcagatcct caatgctctt tgcaatcatc gctaattcat 2328181 catgcccttt tatcgtcatc tcgtagtcca gttcgccccc ttcaagaata tgaatctctt 2328241 gatgaatcgt tttaaggtag cgaagacttt ggcgaattcc gaagagaaca atgattaaaa 2328301 agatgagggt tgccccgagc aaatccaatg caaaggccag atcataatat cgggaagagt 2328361 agaaaccgtc gataatgact cgtccttcac catcgctaaa cttgacagga tgtgaatgat 2328421 tttgagcgta ctgagtcagc ttttcctttc cataatccga ttcggaataa atagaatcat 2328481 attgcagctc ctgatccttg aatatggtga ggttaatgta attttctttt ttgacccact 2328541 cgccaaacgc ttttctatct gatgtagaca actcattttc tgaaacgtac ttgctgaatt 2328601 tttgaatgta tcttgctgac tcctcgtgat aatactcttc cgaactcaga tatccctcga 2328661 tcagatcatc tgtgatcttt tgcaacgtca gaaagatcac accactcaca atcgcagcaa 2328721 ccattatcag caaagccagt tttttggtta gcgtaaattt aagatgcgcc aaatcgatat 2328781 cctcttcccc attcagtttt tatataaacc ggacgtgccg gatcatcctc aattttggag 2328841 cgcagcttcc gtatatgcac catcaccgta ttgttggaac agtaaaagta aggctgtccc 2328901 cacacactct catatatatt ttgggcagaa aatattttgt tgcgtttgtt catcagaagt 2328961 ttcaggatac gatactccag atctgacaac ttgatttgct tctcctcttt ccacacctca 2329021 ttaaattctt cgctcactct tagtttgccc ccgataagaa atgtttcttc ctgttccttc 2329081 ttttcctgat agatagtata tctgcgtaat tgagcaatca ctctagcgtg aagttcctct 2329141 tccgagaatg gtttagtcat ataatcatcg ccgccggcga gtaatccctc agttttatcg 2329201 agtgtactcg atctggccgt cagaaacaga atcgggacgt tagaggattt cctgatgtgc 2329261 tgacatgttt caattcccga aatgcctggc atcataatat ccaaaataac caaatcaagc 2329321 gagtcattca caagttgcaa tgctcgcttt ccatccttgg ctcttagcac ctcgtaacct 2329381 gcacgtgtaa gggattcctc caaaagatca ccaatatcct catcatcctc tacgactaat 2329441 attcgatagg ccatgtctct ctcacctcat gattcttgtt gttatttctc gtgtgtcctt 2329501 actatatatc gttcatagta ataagtacgt tataagatac tacgtaaatc ttaacaattt 2329561 atgaaagctg atgctcgcca caaatttgtc acattttcta aaaaaaatga tgactcttca 2329621 taaattgtta agattcggtc tttatattta tccattgtaa ggctcaagtt tttcagatcc 2329681 gcactacaca ttgccgtgat aaatgggaaa ggagtattga tatgattgta caaaaagaag 2329741 gacgcgggca accggtgagt ctgcgggaac gggttcattt tctggacatc gtacgaggat 2329801 ttgccttgct tggcattatt attgtcaatt attttctgat cgtagattca gtaaagggat 2329861 tcgaaatggc ctccgatgac gtactgcata agctggtttc ctggtttgcc gaagggaaat 2329921 tcgttacgtt attctccttc ctgttcggag tcgggtttat gatctttatg gatcgagccg 2329981 cgcagaaggt agagagtccc aacaagctgt ttgcccgcag gttatctatc ctgttgggat 2330041 ttggcatttt gcacatcaca tttgtttggg tcggtgacat attggccttt tacgccgtaa 2330101 gtggcttcct gttactcgcc ttctataaac gcacggccaa aacggtgctt agatggatta 2330161 tcgcacttat cgtgtttcaa ttcctgactc ctgttttcac aatgttgtac aatgtcatca 2330221 atactgcagg gtcaaaaaac ccgaattttt cagagtttac tttgtttagc cacagcagcc 2330281 ttacctacat ggaatccatc agcactcggt ggacagatat ggtcacgatg gctgccggct 2330341 ctttctctat gatctattcc atgtttctca tgtttctgct gggcgtgtac tttgttaaga 2330401 tggaattttt caaagacatg gaagcgaaaa agcctatatg gaagcgtatc tggatcatta 2330461 gcacaatcgc ttttctaata acacaaagca gtatattact agacatgttt aatctttctg 2330521 agaatatgct gtggaaggac atttcctctg tcttgggtca aaatggcggc ttaaccggaa 2330581 gtatgtttta tatgagcact tttgcaatgc tgtttctata ccttcctcag ctgcgaggcc 2330641 ctatgatgat attcaccaaa gtcggacgga tgtcattgac ctgttatctg cttcactcta 2330701 tcattggaac agttctgttc ctcaggtacg gattcgggct tgcggatcat attcaatccg 2330761 ccggcacgtt catgttcagt ctggccgtgt acttcgttct tatgagcttt agtacattgt 2330821 ggttgaaacg gtttaggtac ggtccgatgg aattagtatg gcgcaagctg acgtacggca 2330881 aagtaaacgg gagtcccaaa gcaactccgc tgcattcgga aaaatctatt cagaaataac 2330941 ccccttgcac agattgcatg acttcaaatt agtgttgttg aatgaagcgg gcattaaacg 2331001 gacagatttg atatatggac tagttatttt tatatcattt aggcttcttt gggctaataa 2331061 atccaccaga gtttactcaa tgtgcattgc tcatgatcga atctaaattg aatcttttac 2331121 gcatgttcat agtcaaaggc gcctcattcg actatttttg taacttttcg caggaaaaat 2331181 tcgagaatga tgacaaatcc cgcatacgac acttaatacg gtagtgaaca atagtaaatt 2331241 agggttacat gcagcttgtt ttccaatgaa acaaagaaaa agaatcatac aaaaagacag 2331301 gagaaagctt ttgaagtatt ttaacgccaa atttaccgcg gaagaaagag cgatggaatc 2331361 acttttttgt gaaaaggcct cgcagagcag ctcgaatgtt ttactgaacg actgaactct 2331421 atattttagc aactgaggga gtgaacaatc atgaaaacta aaaatgaacc aaaagttatt 2331481 ctggaactag caaaggaatc tgatctgcca gaattccaaa aaaaattaca agaagccttt 2331541 gcgatcgccg tgattgaaac gttcggtgat tgcgaagatg ggccgattcc atcggacaat 2331601 gatgttcagg agtctttcaa tgctcccgga gcagtggtat atcatattct tcaggatggt 2331661 aagaatgtcg gtggtgcagt agtacgtatc aacagccaaa caaatcataa ttcgctagat 2331721 ttattctatg tatctccaga atatcacagc caagggattg gtctttctgc ttggaaagcc 2331781 attgaagcac agtatccgga tactgtgctt tgggaaaccg tgacacctta tttcgaaaag 2331841 cgaaatatca acttctatgt gaataagtgt ggatttcata tcgtagagtt ctacaatgaa 2331901 catcactcta atccgcatat gcatcgcaat ggacgtgaag atgacaagcc cctactgaat 2331961 gatgatgact ttttcagatt tgtaaagatt atgaaaaaaa aggactaaac aattgaacac 2332021 ggcgagatgc cgcagagagt tgctggtaac ttttttatat ttcattatca gaggaaggta 2332081 ataatgatgt ttaaaaggtg ttttgatccc tgtctcataa acaggggtca aaacaccttt 2332141 gaatcatcgg tttcttttct gacatatacc acgcccacta gtccctcaac atagtaaaaa 2332201 catatcatga gttacaaaag cttttattca aagcatatgt ttattttatt tatacttatt 2332261 ttcatcattt ttcagaattc tggacacaaa tcgggtacct attagaggcc aaggaactct 2332321 acatttcatt aagaaatacg tactcattgc cctgctttaa ttaattttaa gccctcgcac 2332381 tatgcccccc cctgaattaa gtatttgatg taactttgaa attaagttta tgaaaatctg 2332441 tcacaaaccc ttatttcata acacatcatt tgtttcagct tccctcgcga ataccggatt 2332501 aatgctcggc tttaagatag tcaaccaatc tctccgcact gttcttaaca tcttcttttg 2332561 aaagatgaag tgtcccatat tgtgtaaacg caggaagaaa acgcattcct atatagttag 2332621 cagtgacttg aaacggtctg ataagctcgc tgatcgtgat attatattct ccgcctgctt 2332681 gataatcaga ttcctgtgcg cctaaggaga tagctaagag tagttctttt ccatgcaatt 2332741 tagttcctcc agttccataa gcccagccat gtgttaacac atcatcttcc cattgtttga 2332801 gtaacgcggg actgctgtac caatacattg ggaactgaaa aacgatacgc tcatgatcta 2332861 acaggagctg ctgctctttt tctacatcaa tgataaaatt agggtattca ccgtacaggt 2332921 catgaaccgt aatgtctttc tcttgcttta aacgattcat ccaggttttg ttgacaacag 2332981 acgtttccaa attaggatgt ataacgataa ctaatgtttt cattagactg attatccttt 2333041 ctttgccaat tagttattat tttttacgat aatgaattga ttctaatttt aaaatagcaa 2333101 ctttatttac acctatttta tcctttttca tgaattcagg gcaactaatt gggcaccaaa 2333161 atcaatgatg acttaagaca ttgttttgta gaaatccgat atacagaata atccattatt 2333221 tagaaaattt ctaccttttc cctcaatcct taccaattta aactcattaa ggagatactt 2333281 tatcaccaac tttaaataat aatggaataa gtgctaataa aataattcct acaaccaacg 2333341 tagatattat taactccttc catacaatca aattctttaa aaacatttga taaataacta 2333401 atgagtttac tggaatgtta agcaataagc ccgtaagaag tccaggtgca tactttttca 2333461 ttacaacagt tgcgataaga tgtggaaaaa tagcgttgat aaccatagaa cctagaaagc 2333521 caatgaaaat ccattttgca atatctgatt ctggcatata taaaaaacca aatgcagata 2333581 aataagccaa catagttata acaatgacag caaaatgaaa ttcatttgaa gttactggct 2333641 tttgaaactt tgaagattgt tgtgaccact caggtaacca aatagcttcc tcaatattat 2333701 gaagtgtaat agcaaaacaa aaaaatgcta cgaaataaac cacctatcat ttcctcctcg 2333761 gtgccacaac caatatggtt tggcaacatt atattacatt tgaggctgat tggatatggt 2333821 gttaaaagag agaagaatct gccttagtag ttgcttctta attatatgtg caataacgtg 2333881 ttgttacgtg gcatgtcata ttcaaatata ataactctaa agcaaacaaa gatacctata 2333941 tagtttggca tcctcttttt tagttcgagt ccctctattt attttgggca caaaatagac 2334001 ataatttata ttgactcatt atacccatca cataccatac cccttaaacc aatcaggatt 2334061 aaaatgtttt aaaaaaggtg atcaaagatt aagttatggt ctcttttatt ttatgtatgc 2334121 tgtcttaatg caaaacaaca ctggacacca ctaagtcaaa tgcatttcat ggtactatag 2334181 tcaagacttg tccaagtcac cattatcaaa atgaatttca tcaaacactt gaaacattta 2334241 ttgaacgcgg ccaagtgtca taacattaat aagaaaccaa cgagtgatga atcttttaat 2334301 ctttcatttt acccgctggc tcatatcaaa ggagctctaa ccaaatttta atagctgtcg 2334361 cacctattaa ttgcgctaaa acccattgca ggaattttgt atttactttt tgcccaactg 2334421 atgcgccaat aggagaagct attaaactag taatcataag aaccagagct ggtacaaaaa 2334481 gaacctggcc cgtgattact tttccaactg ttgcgccaat ggatgaaaga aatgtaatcg 2334541 caagagatga agcgactgtg actctaacag gaatatttaa aatcgataac ataatgggga 2334601 ctaggataaa ggcgccgcca gctcctaaaa tacctgatac gccaccaatg ataaacgcta 2334661 aggaagaagc caaccattta ttaaatatca cttccttatc ttcgctatgt tcttgtcctt 2334721 tctgtccttt tttaggtata aacattaaaa taactgctat aatagccaga attccgtata 2334781 taaagttaat tcctttttca gatatataat gagaaaagta actccccaat acactcccta 2334841 aaaggatgct gcttcccatg taaataatta atgttttatt tataagacca ctcttacgat 2334901 aagcccaaac accgccgagt gtcgcaaaaa aaacttgaat agcccctatc cctgaaactt 2334961 catgggcagt taatgacatc actcccacta aagaaggaat gtacaatagc attggataat 2335021 taataactgc tccgccaata ccaatcattc cggaaataaa ggcaccaata aaccctataa 2335081 tgaaaagagt tgtgataaag gcaatatcca ttttatttgc ctcctttcat aggaaaaggg 2335141 tatctttcta ttcgataccc tttcacattc attagccttt ttgaatccaa aatttcaata 2335201 tatcgccctc gtccgtttgc tctaaaaggt catgtccgcc tgatttagac caggctgtaa 2335261 gatcattttt ggctccctta tctgttgcat gcacttctaa tatttgacct gattccagtt 2335321 cattcatcgc tttttttgtt ctgacaattg gcattgggca tgccaagcct tttgcgtcta 2335381 atactttatc tgatttcatg ttcttctctc ctctttttag cagaaacttg tgttaccgta 2335441 ttgcacagcg gtttgggcca atctccattt cacgctgttt ttcttcatct gggctgattt 2335501 tccccatgtt tgtttctcga atctcttggt atgcatttgg ttgcggaggc aaatgatctg 2335561 ttactaggtg tctaaattct gtttcatccg caatgttcaa accatggttc tcgctaaata 2335621 atgtacttag ttgtttacca acacttccat tctcatttag ctcgtcaatg atcataaagt 2335681 gtgccggtaa tacaattaaa tcctttgata acgctttgta acggctataa agcgtttttc 2335741 ttaaatctcc tacccaatct tctgccatac cggctaagtc tggtctgccg attgaatcaa 2335801 taaacaagat atcacctgaa agaagatact ggtcatcgac aatgaaagaa gtggagccaa 2335861 tcgtgtgccc cggagaataa atcggttgaa ttttaatcgt tgtatttcca ataataatgt 2335921 catttccttc ttccaacggc tgataatcga attccacttc ttcagcatct ttaggcggta 2335981 accagtaggt tgcttttgtt ttttcagcaa tgactctgcc gcctgaaata tggtccgcgt 2336041 gaagatgtgt atcaaatacg tgagtaatcg ttgcaccctt ccccttcgca aaatctataa 2336101 agaaattcac catacgtgtc gcatcaataa ttgctgcttc accattggaa atgaccatgt 2336161 atgacaagca gcctttaccg attcgaacaa actgatacat ctcaccgcca tcttttaaat 2336221 ccccgacttt taccggctct aaatgttcgc tccatgcttt cattccaccc ttaaggtagg 2336281 atacagaatg acctgcttca gaaagcattt cggataccat gacggatgaa ccttcttttg 2336341 cgcaaacgac cagcacttct ttatcagaag gaattttctc caagatatct tctacgccat 2336401 ctaaaagatc aaaataagga acattcaaat ggtcaaagtc atgcccttct atcttccaat 2336461 cactaaaatc attttcatta cgcacatcca aaataaataa aggttctttg ttaaagattt 2336521 ttttgtcact tcttttgggg tcattgcctt tacggtcatg tttcaatacc tcctatatca 2336581 aatcttttag cgggactaaa acgttaagga tacatcagca tctttcgtaa aaccaaaaaa 2336641 ggtaacagcc ccgcctactt cgattccttc cataaaatca tcttttgtta aacccataac 2336701 gtccatcgtt atttgacaac caaatcatgc aactcccatt tcaatcagtt aagaatagaa 2336761 ggcacatttg cgttcctaca accttctgcg acatgctctt ttccttgtcg caatattaca 2336821 gactttataa gcatcaaaca gaccgctatt tgccgcaata atcgctactc ttgtactcat 2336881 ctgttcatca tgctttttat ttattcggtt ttacctgtcc aatcccgcat acccgggaca 2336941 acattaataa cctttttaaa accttgtttt ttcatggtgc gggccgccat ttcactcctt 2337001 cttcccgaat ggcagataat ataaatttca tcattttcgt ttaattcgtt agcgcgcttt 2337061 tccacttcac caagagggat atgcacaact cctgggatat gagctttttc atattcctct 2337121 atctctcgaa catctaaaat gttaagagac tcgtcactat ctactttctg tttgaaagct 2337181 tctaatgaaa tctcaggaat tgaagatgca ttttctgatg aatgctctcc tccttttcga 2337241 agaaaatgac gaagtatttc tccctctgct tcagtaccca gatattcatg gcctgtactt 2337301 tttgcccatg cttccagatc tgctgtagaa cctttatctg tcgcatgaat ttccaatact 2337361 tcaccagctt ttaaatcctt cattctcttc ttcgttttta cgataggcat tggacacgcc 2337421 aaacctttag cgtctagtac aatagttgct ttcatcattt tttcctcctt ttcttatata 2337481 ggggtggggg tatacaaata tacaaaaagt ttctcactgt aagttaacac catgtattca 2337541 tacccccttt tatatttgtg atgtttttaa atccttgttt cttcaatatt tttacttgcc 2337601 tttaaacttc tcattccgct tagcaatgag taaatgagta acattagata aataagttga 2337661 cactgccttc ctcagcatct gccaaataag ctgctacacc agcatagtca atatcatcta 2337721 atagttcttt ttcctgtaaa ccaagaagat ccattgtcat cgtacaagct acgagcttta 2337781 ccccctgttc ttgagccatc tcaatcaact gaggtaaagt aagtacatta tgctttttca 2337841 tcacattttt aatcatttta gggcccatac ctgcaaagtt cattttagat aaacccatct 2337901 tatcagcacc acgaggcatc atctttccaa acattttttc aagaaatcct tttttcactg 2337961 gaatcagctc ttctttacgt aaagcgttaa atccccaaaa agtatggaag atcgtcactt 2338021 catgatcgta ggcagctgca ccatttgcaa taatataggc tgccattgct ttatcataat 2338081 ccccgctaaa taaaacaatt gttgtgcgtt ttgtttgttc tgtcatgttt attctcctaa 2338141 ctaattaccc ctgcgggtat attaaagtca aaaaattttt tcgaaagatc tgcttttatt 2338201 caactcttta aataccatag ggggtataat ataacgcata taaaaattcg tcaaccttag 2338261 gttgatgaat ttttatcggc tctttaccaa taagtcgact gcttctttta ctaaattttg 2338321 tgtgtcttcg cctttttcta aactttcacg aacacaatgt tcaaggtttg tgctcacaat 2338381 taaacccatc gctcgatcga tcgcattacg ggaagctgct aattgggtca caacctctct 2338441 acaatctttt ccttgttcca tcatagtcaa tacaccttta atttgtcctt caatccgtcg 2338501 taagcggttt ttaatctttt gatcatactc catatatcaa tgaaatcctt tctttcattt 2338561 atttttacat ttacatgttg ccagttcata actgtttaca tggatacctt tgcgctttag 2338621 aaaacgcact cctaaattta attccacccg gtcacgagct attatgtgta ttttatcacg 2338681 tggaatctct aaataaaaac gttttagata cgcatatggg atgtttaaaa taatattatc 2338741 cgaaaaattg gctacatcgt tataatgacg aatatctaat attgtgatgt ccatagcctc 2338801 taatttatct ttatggatac aagagattcc ggttatagga taataacgtc tatacgttgc 2338861 aatgataatc acaaaaataa gcaggaatgc aataactaaa taattgatac tatttacacc 2338921 accttattaa ctctttgttt attcacaaaa caataatata cccccatagg tatatagtca 2338981 agtgtgaaag ttactttctt tgagctgata gattcatttc gatatccgcg gattgaaaaa 2339041 atacttacat tcgataatgc caattctgct aaaaggaact cgaataaagc aataagccga 2339101 tttaatttta aatcggcttt atttatcaat tacttaaaat tagcacaaga cacgctgctt 2339161 ggatattaaa tggggtttca ttagcatggt actggttccc catgtttcat gctggatgtg 2339221 actttaatta ttctagaatt ctccagaata tctgtgctaa tcttccgcag ccactgcatc 2339281 tgctttggtt tcatgaactg taccaaatgg atggttagga ggagcataaa tggagtaaag 2339341 ttttaatggc gtatttcctg tattaattac gttgtgccaa gtgccggcag ggacaacaat 2339401 ggcagaatca tcatagacat ttctttgaaa gttcaaatga tctttgctct ttcccatttt 2339461 gacgatccca cgcccctgct caatccgtaa gaactggtca acgttaggat ggatttccaa 2339521 accaatgtct tctccaatac caagactcat caaagtaact tgaaaatgct ttcctgtcca 2339581 taaagcagta cggaacgtat tgttttgttt tgtggctcta ttgatattta caacaaatgg 2339641 ttttggtcca taatccttca aaagaaggtt tctatcttca tatgaagagc gcaaatcggc 2339701 acctctgtgt actttctcca tctcatttgg aatagtccaa taaacagatc ttccatcatt 2339761 atacatcggc acagtcacat aataataaca ttgaggcgaa aaagggttat agtacatttt 2339821 ttgatccccg caattataaa tttttgtgat agtatcctat gcatttatta agggagtgtg 2339881 ctaaatcaag aaaactcata ttaaacacaa aaatgaatgt tcgatcaccg tttgattcat 2339941 ggatgaataa tttatcaccg accttgtaat cgttttctag atgttgaatt tcactagcct 2340001 ttgttaacaa gacatcgaat gacaccttta tatgatggat tatcaaaggt cgacgatcct 2340061 aaatggcttt tgaacattta catagcacaa caacagagta tacggaattc tgttgtttgt 2340121 cccccctatc ccagctcttt tagatttatc tctttggatg cgccttgatg gccagttttt 2340181 cagcagcata gaatttatcc cctcctgaat cgttatagca tatttcaacg ccgatagact 2340241 tgcggttccc agtgccgttt gtaccgtctc ctgtatgtgg gctcgctttt agtaaaccag 2340301 tttatattct ttttgggcac acaacagaaa caattttcca tatgaaaatc tcgtaatttt 2340361 acacctcttt aacttgaagg aggatttttg catatgtatt ttcatacccg tcaactacca 2340421 tctcatccag catatattcc tcatatgcat tttcccctat ttgcattcca tttctttcaa 2340481 tgaactcaat gattctccgg tacgcctctt cagtatttcc gcctatttca tatccaactg 2340541 catacaggcc ttttggccgt acatgataat ttatgttctc tgccccatct tttactttta 2340601 tataaaagta actgtaattg tagaagtctt tttctaagat ttgttcccgt gcaaagattc 2340661 cgcctatcgg atatccttca tctaattcat attgctgaac ttcatgaatg agttctgaaa 2340721 tggctgccac atattttcgt tctggtaagt ttaatgtttt tcggcttaac atgaatgttt 2340781 cttcatttaa atattcaaaa gaaattgagg aaaaatcagt ctcaagtgct tgttctgtaa 2340841 gcgtcacttt tgtttgtaag atcgtttgca actgcttaag ctcatttatt tttttatcaa 2340901 tctcaataga cttttctttt agaacatgca ggatcttgtc tggtgttttt ccttttatta 2340961 gacactttat ttcttttaat ggaaccccaa gctctttaaa tagactgatg acttgaaaag 2341021 tctcaaattg atgataggaa taatatctat acccattttc tttttttatt tccggcgaga 2341081 aaagaccaat ctcatcataa tgaaataaag tttgtttttt tacacggcag agcttcgaaa 2341141 actcccctgt tgtgaaatac ttcttaacat cttcgctcat aaaaacctcc ttgactatac 2341201 ggtaaccata taccttatga tttgattgta cttgaaaaaa gcttcaagcg aaaaggatag 2341261 gtaaaaaggg ttcaattgag taaaagggga attcagatga aaaaatcaat aaatgagcaa 2341321 aaaacgatat tcattatact attaagcaac atcttcgtag catttcttgg tatcggttta 2341381 atcattccag ttatgccttc ttttatgaaa atcatgcatt tatccggcag cacaatgggt 2341441 tatcttgttg cggcttttgc catttctcag ttaattactt caccttttgc aggtaggtgg 2341501 gttgaccgtt tcgggagaaa aaaaatgatt attctcgggt tgcttatatt cagtttatct 2341561 gagttgattt tcggattagg gacccatgtt tcaatatttt atttctcgag gatattgggt 2341621 ggtgtaagtg cggcttttat catgcccgcg gtaacagcat atgtagctga tattacaacc 2341681 ctaaaggaaa ggtcaaaggc tatggggtat gtttctgctg caattagcac cggctttatt 2341741 attggacctg gtgcgggagg atttattgcc ggctttggta tccgcatgcc gtttttcttc 2341801 gcctccgcca tcgcgttaat agcagctgtc acttccgttt ttatactaaa agagtcattg 2341861 tcgatagaag aacgccatca actctcatct catacaaagg aatcaaattt cattaaagac 2341921 ttgaagagat ccattcatcc tgtctatttc attgcattta ttatcgtctt tgtaatggct 2341981 tttggtttat cagcttatga aacggtattc agcttgtttt ctgatcataa atttggcttc 2342041 acaccaaaag atattgcagc cattattacg attagttcca ttgttgcggt agttattcaa 2342101 gttttactat tcgggaaatt ggtcaacaaa cttggagaga aaagaatgat tcagctgtgc 2342161 ttaataaccg gtgcgatctt ggctttcgtg tctactgtta tgtcaggatt tttaactgtt 2342221 ttgcttgtaa cttgttttat ttttctggcg ttcgatttgc tacgtccggc cttaaccgct 2342281 catttatcca atatggccgg taaccagcag ggtttcgtag caggcatgaa ctccacatac 2342341 accagcctgg gaaatatatt tggacctgct ctaggcggta tactatttga tcttaacatt 2342401 cattatcctt tcctttttgc aggtttcgtt atgattgtcg gccttggtct tacaatggtt 2342461 tggaaagaaa aaaagaatga tgctgcagct ttgaattaat tcattttcta taaagttaag 2342521 tcatttggat gcagggaatg cccctggtta ggcacaataa gaaaaggtac ttaatttgat 2342581 aggctacatg ttgcttgacg tgaatatagt ataagctgag ttttagcaat atcaggatac 2342641 cgggataaga aaaaaggaga atgtagtatg agtataaaca taaaagcagt aactgatgat 2342701 aatcgtgctg caattcttga tctacatgtc agccagaatc aattatcata tattgaatct 2342761 acaaaagtat gtttagaaga tgcaaaagaa tgtcactatt ataaacctgt cgggctttac 2342821 tatgaaggag atctagtcgg ttttgcaatg tatggattgt ttcccgagta tgatgaagat 2342881 aataaaaacg gacgagtctg gcttgaccga ttttttattg acgaacgcta tcagggaaaa 2342941 ggattaggga agaaaatgct taaagccctc attcagcacc ttgctgagtt atataaatgc 2343001 aagagaattt atttaagtat atttgaaaat aatattcatg ctatacgcct ttatcaaagg 2343061 tttggttttc aatttaatgg tgaactcgac tttaatggtg agaaggtaat ggtaaaagag 2343121 ctatagatat ccaagcctcc ttgtttgctg agaaacgttt gaacttcgat aatgattacc 2343181 tacttaaact gcaagatcat tgtttaaaaa agcctggatg aaaatttcat ctcaggcttt 2343241 aagcatctta ttagtcaaaa tctcatgtgt tttatccaga tgttattctt ttttccggac 2343301 aatttctaaa taattaatat gccggccaac tgtttcgtgc actttaaaaa tatacccatc 2343361 ggcttctata acggacccaa ctgcagcgtc tatttgttga gtcataaacc agccgcctat 2343421 tgtatccact tcgtcacttg ctaacgtcgt tcccaataaa tcatttacat cttcaatgag 2343481 cactttcgaa tctaagatat agtgattatc atttactttt ctaatattag gcacttcatc 2343541 tttatcaaat tcatctctga tttccccgac aatttcttca agaatatctt cagcagtgac 2343601 taaacctgaa gtgccgccat attcatccac aagaatagcg atatgtgttc gctctttttg 2343661 catttttacc aatacatcat gaattggaac ggattcaata acatggataa cagggttgat 2343721 atgattttct aacttgaaat cctcttttat cttctggtct gtgtcaatat aagctgacaa 2343781 aaattcttta gcattgataa aaccaatgat tgaatcttta tctccattta ggactgggta 2343841 ccttgtatag ctctctgtct taatgatctt aacaatagtt tcataagaat cctcactaga 2343901 aatcgctacg atctctcttc tcggaatcat aatttctttg gcgattcttt catcaaattc 2343961 aaaaatatta tttacatatt tcaactcatt ttgattgatt tcaccgctct tatagctttc 2344021 agacagtaag atgcgcagtt cttcttcaga atgagcaagt tcatgttctg atgcaggttt 2344081 caaaccgaag agtcctacta taaaccgggc tgaaccattt aaaaaccata taaaagggaa 2344141 caggatgcgg taaaaccaaa taattggctt tgcagtcaaa agagtgatgg tttccgcttt 2344201 ttggatagcg agtgttttag gagcaagctc tccaactaca acgtgcaaaa aagtcgccat 2344261 cacaaaagca atcactaaga tcaatacatg tgagactgtt tcacttacat gaaaatgagc 2344321 aaataagggg tgcaaaatca cttcaaaagt cgattctccg acccagccaa ttcccaacgc 2344381 tgtaaccgtg atccctaatt gacaagctga caaatattcg tccaaatgag taatgacctt 2344441 tttggctgat atggcacctt tttttccctc taatatgagt tggtcaattt ttgatgacct 2344501 gatctttact atcgcaaatt cagtcgcaac aaaaaatgct gttaagacaa ttaaaagagt 2344561 aaagattata aggttaatgg ttgtcaatga tttgccttac ctagtaaggc gtacacctcc 2344621 gatgtaaata tttattgaat aaacaaaaaa cagtatatat aacattataa gttcaaaaga 2344681 acctaaaatc aactctgaat gatgtaaata atcatctttt tccgtatgga gagtggttcc 2344741 catagtcttc aactaacgat tagtggcgtt ttaaggctta aaaaagaaag caaaataaaa 2344801 acacacctga attttctggt gtgtttcaat aatacccaac cgtcttgatt tatttaatgt 2344861 ctttataaag attttctttt aaaatttgaa tcaattcggc ctgttgcttt atatttttgc 2344921 ggccatttct attaattgca gcaagttcac agacaattcc agctgaaatg aaaaacaata 2344981 aaccttcaaa cattttaaat cccccactgt ctaagtgata gtcaaatttg ttttttcttt 2345041 ttgcaatacc tgcttataat cttccttacg ctgatatatg ttatttaaaa tgagtccaat 2345101 aatgacaaac agtgttccta ctatatcaaa agcagttatg ttatatcctt tgatcaccat 2345161 gattaacaat gtagtaatgg ggacaaagtt aataaataaa atcccattaa tggatgatag 2345221 gattttaatg ccatagttcc aactaaggag ggctatgata cctggtaaag taatcataaa 2345281 taaaaaatca tacttaattg ctgcaatcac tttaatactc ggtaccgaca cgtaaccttg 2345341 cgcggtaagt atagctgtca tgattcctgt tatagctgtg ccgaataaac atgtcaaagt 2345401 tgaataacga agtgtggacc actctcggaa tatctgtccc cccattgtgt agacaaccca 2345461 ccctaaaaca ccaatgaata taaagagtat cgagaataga tgatccccta atgaaaaaaa 2345521 gaaacttata ttacctttgg ttatgaccat cgaagccccc aaaaaggcaa tcaatatact 2345581 gatcattgtg tattttttag gtttcacatg tttatatccc catagaataa caattgaaag 2345641 catcggcatg agtgcctcgg caatggatgc tgtcataatt ccagacttcc ccatcaacct 2345701 ttgacctaaa aaaataagaa cattgtatat agtaaacgcc atcaccccaa ataaaatgat 2345761 ccattttgct ttaccctcta aatgaaatga tttctttcct tctctcacca ataataaaat 2345821 cactaacata atcgttacca caccgtagcg aataaatgaa aaataaaacg gatcaacaaa 2345881 ttctaatgca tgatctgcaa ctggaaacat cgcgccccaa gacatacttg ctactaaaca 2345941 tgtaagggca ccaatgaata attgaccttt tttcattgaa ttcccctcct tttctttaaa 2346001 attacaatga gaattataaa aagaagtaag catcaagtaa aatgaacaaa agtgatgaaa 2346061 aacatcattg ataatgatac tttaatgaag gggggatctt catggaactg cgagacttac 2346121 aaattttcaa atgcgtagcc catcacaaga gtattaccgg tgctgcaaaa gagttaaatt 2346181 atgtacaatc taatgtaact gcgcggatta agcaattaga gaatgagctc aaaacacctc 2346241 ttttcaatcg ccataaaaaa ggggtttcac taagcccaga gggccgaaaa atgattgaat 2346301 acgttaacaa aattttgaaa gatgttgaag aactggagca agtctttcta gatactgaaa 2346361 taccgtctgg aatattaaaa atcggtacag tggaaacagt gaggatactg ccgaccatca 2346421 tagcttccta ttataaaaag tatcctaatg tggatttatc attgcaggct ggtctaacag 2346481 aggaacttat taaaaaggtc atgaatcacg aattagacgg agcttttatt tcaggcccct 2346541 tgaaacattc tattctggaa cagtatgatg tttatactga aaaacttact cttgtaacca 2346601 gtaacaaaac gtttaatata gaggattttt caacgactcc gattcttgtt tttaaccagg 2346661 ggtgcgggta tcggtctagg cttgaacaat ggctcaaaga tgaaggtgtg ctcccaaaca 2346721 gaatgatgga atttaacatc ctagagacaa tcttaaatag tgttgcactt ggactcggta 2346781 taacagtggt accggaatct gctgttatgc atctagctgt acaaggtaag gtttattgcc 2346841 acccattgcc tgagaaagac agctgtatct caacaatttt tatacgccat aaagatgcgt 2346901 acctgacaaa ttcaatgcgc agcctcctaa agaccattgt tgaacataaa aatatgagta 2346961 tggcttaaag tgatttttct ctttctatat tctaacttct taaataaaag agaaggctca 2347021 tctccacttc gctaccctta ttcacgcaaa aaatagagca gtaaacatgt gagttactgc 2347081 tctgcttcgt ttattcaccg ttcatttgtt ttacaatgta ttcagcatca tttcctacgc 2347141 cttgaagcaa cgctgaacct cgcttatgct gccaaggcaa acctataaag tacaatcctt 2347201 ctacaggtga aacacctcta tgatgtatga ttcgaccttc ttgatccaaa acacctttta 2347261 tatttatcca acataaggga ttcctgaaac cagtagccca aataatattg tttacttcta 2347321 atgtagatga atctttaaaa atgatttcat tttgctttgc ggcaatgact ctttttttta 2347381 agatgatctc cttctgtttt attgcatgtt ttaattcatg cccaaatact ggatcacctt 2347441 tcttttgaat gaatttgcct actattgatg tatgacttgc atgtaaaact cctagtttat 2347501 caaaccacca aaagatgctt ctttttccga tcattaaagg gaaataaaca agtttattac 2347561 tacaagctaa atatgtaact ctttctttgg ataattcaac agctatttga gcaccactat 2347621 tcccaccacc aactactagt acatttccat atgccaattg ttttgaattc ttatattgtg 2347681 atgagtgtag ttgattaata ttatcggata aatcctttga tattgatgga atattagggg 2347741 tatgaaaagg ccctgtagca atgacaagat tcttcgtttg atattcttcc cgatttgttt 2347801 ttattaagaa ataattcttt atttttagga cacttattac ttctgtccgt aattggattg 2347861 gaatttcaaa ttttttaaca tacttcttta gataagcaac aatttcattt tttgaaggaa 2347921 atccatgttt ttctccttca agatgcattc caggcaaaga gctatacatt cgagaagtaa 2347981 ataaaactaa tgagtcatac cgatctttcc agctctcccc cacctcatga cttttatcca 2348041 aaatgataaa cttttgatcg gactgcttaa gataatatcc tattgagatc cctgcttgac 2348101 cagccccgat tactatagtg tcgtacacat tatcaccccg ccaatttcaa attgtcagta 2348161 gacagaatct gcaaaatcct agttgatctc ctcactataa agttagataa aaaatttaat 2348221 ggtgatggtg gtcacgctgc ttctccattt tgggctgaca aaggatcgca ttgtcgtggt 2348281 tatgcgcttc ggtttccatt tgaatggtta cgtgcgtaat gcctttatgc tcaagttcat 2348341 gttcaatttt gcgtaaaata ttttcacttt ctgaaatggt cagttgatcg tcaacaactg 2348401 cgtggcaaga aagagcattc aatccgcttg tgatagacca tatgtgtaaa tcatgaatgt 2348461 tttgaattcc ctctgtccct tcaattgtac gaatgatatc agagacatcg atattttctg 2348521 gagttccttc cattaagatg tgaatggaat ctttagtcac attgtaaccg cttcttagaa 2348581 caagaatagc cacaatgata ctagccaatg gatctgccca gccccatcca aagaagatga 2348641 taagtatggc agctaaaatg gcacctacag agccgagcat atcgcttatt acatgtaaat 2348701 aagctcctct tatattcaga ttattctttg tatctccgcc actcatcata atccaagcga 2348761 ccaatagatt cacaactaac ccgatgatac taattgtaag catgccggtt gttgctactt 2348821 ttggtggatt agagaagcgt tcgattgctt cataaatgat ataaagagaa ataagaatta 2348881 aggcagcacc gtttatcaca gctgcaagaa tctcaaatcg tttatagccg aatgtcttat 2348941 tgtgatttgc ctttttttca gctaatgtaa aagcaatcag ggcaaccatt aatgaaattg 2349001 aatcactcag catatggcct gcatcagata aaagcgccag gctatttgtt aaaaatccac 2349061 ctatagcttc tataatcata taacctgtaa tcatgataaa agagatcaat aaaacctttt 2349121 tatttgctcc ttcattatga ttgtgaccca taaaaaactc ctccttacct aaagttttta 2349181 atacatatgt atttattatt tcaaatctgt tatgaagcat tctaacatga tacaaataat 2349241 atttatatat gagcatgtgt tcatatataa atatatctgc tctttactga aatgtcaaaa 2349301 tatttttata gaaatccaca atacctcctt aattattctt ttataaacat aaaaaagcgg 2349361 agcaaacaca tggtttgctc cgctacccta gtttctctat ccttttcttc aatcaagcat 2349421 ttgagggtag tattcaacta caatttacct gttaaaaatt gggcctcacc aagtccaaaa 2349481 ctccagtcag cattatcatt ttcaacaata gatacaatta aatcagttga tgcgatacca 2349541 cactcagatt ccagtctttc agctaacagc ctgtaaaatt tttgtttctt ctcttccggt 2349601 cgggatttac ttgtaactga aagaacaaca agatttttag ttcggttaaa tcctaaccca 2349661 gtatcctcaa taatcatatg attttctgga tgttcatgaa caatttgata acggtcttgt 2349721 tgaggcacat caaaagcctc tactacaaca ttgtgagcga catctaaaag ttttttcaaa 2349781 cttgattgat ctcgcccttc tattaagtca aaacgaagta atggcataaa atcccctcct 2349841 tctactacaa cagtcttttt aatttcattc gttaatgtgt cagctatttc caagcagctg 2349901 ctacatttag aaaataaagt aatttcccaa taaccccttc attctggtgt tagtcaagcc 2349961 tatgttatga tgtgtatttc cataggcaat atacagaatc aacttcgagt aattaaccat 2350021 tttttgaaat agctttatca cttactttag aaatcattta ttcttctaag ctttagttta 2350081 catgaagctc tgctatcata tataattcaa aattaagatg gaagacatct caaaatcaga 2350141 tatcaactat ggaggactag atgaatattc agttgttaca ggtttttctc actactgctc 2350201 gtgaaggcag tatttccaag gctgctctga ctttaaatta tgcacaatcg aatgtaacga 2350261 ataagataca acaactagaa aacgatttac agacaaaatt attctatcgt catagtcgag 2350321 gaatcacact tactccccca gggcaaattc ttgtttctta ctcagagaaa attctacata 2350381 ctattgaaga agctagagca gccatgggcg aatcatccgc gccttctggg ccactgcgta 2350441 taggatcaat ggaaacaaca gctgcagttt ggcttcctca actccttgca cattataata 2350501 acctctatcc aaatgttgat ttgaacctag taaccggccc tacggaacaa caaatacaag 2350561 cagttttaca ttatgagtta aacggcgctt ttatttcagg gcctattgaa caccctgatt 2350621 tagttcaaga aaaggtattg gatgaagaga tggttcttgt tacaagtgct tcacaccctg 2350681 tgatttcttc cattcaggat gttcaaacac aaacaatgct tgtattccgt aaaggatgct 2350741 catacagagc aaagctcaat catatcctgc aagaagaagg tttattacct ataaaattaa 2350801 tggaatttgg catacttgaa gcgatcattg gctgtgtaag cgccggcttg gggatttcac 2350861 tgctgcctcg ttcaatcatt gcttcgcatg aaaaagaagg ccgcatccgc agccacacta 2350921 tctctgacaa atattctttt gtatcaacta tgtttataag gcggaaagac actttaatta 2350981 cccctgcttt atctgctttt ttaacgcata tgagggatca ttttcagata aagaggccag 2351041 atcaatcgta aataaatgga tggaaggcat gcttcgcctc aaaatacccc tgatcagttg 2351101 tctgatataa aaatataggc gcatctcaat gtttgtatag agcaaaaaag caaacttcgg 2351161 tatgtagttt gctttttctt cgtgattttg cactctgaat cgtgaaacct agtcgatatt 2351221 aggatgtaga ttttcctcat tcaaagaatt ttgaacgaag gtcattgccc tagacacttg 2351281 gttgcgtctt gaagttaaag gctgactatt tcctaaagcg tcaatcgctc tcacaactat 2351341 taaatattca cctacagatt tcgggtgaca acgggaagat tgatattttc ggttggacag 2351401 gggcagaaca tccaattgta acagttgaag tatccactga tggaggagat cctgcagatc 2351461 tgagtgatat tgctgttgat tgatcaactt gtttttgttc ggaatatact cagtatatag 2351521 ccgcatattc ctcctgcaat agctggaatg agccacccca gccctatgtt atacatagga 2351581 agaatctgag tgaaaatacg attcacaact tcaattttta ttccagccgc cttcaaaccg 2351641 tcaaataggc tgatgatgaa tgcgaataat aaactgcctt gatacacttc tgtcttccct 2351701 ttaaatacag aatgcaaaaa cgttaaaaat attaaggaaa tcgcgatagg atacatcgtc 2351761 agtaagacag gcattgacac cttaatgagc tgggttaatc ctatatttgc gacaagcgta 2351821 ctaaacactg ataaaacgac agcaattttt ttataagaaa tgttcggaaa taattcatga 2351881 aaaaatgaag aacacgctgt gatcagcccg acacttgtcg tcagacacgc cactgtaatc 2351941 attaagccca ataagattga accataagat ccaaaataat aggatgaaac cttagccaaa 2352001 acctctgctc cattttctaa aatccccagt tcttcaacgc tggaagcccc catataggaa 2352061 agggctgtat acataactgc taagagtaca gctgcaatcg cggctgcttt tgcacaaaca 2352121 actatcagct gttttttggt agaagctcct tgttctttca atgcattcac gatgataatt 2352181 ccaaaaacaa atgctacaag ggcatccaga gtgaggtatc cttcctgaaa tcctttaaaa 2352241 aacgcttgtg atgtgtaccc ttttgatggt gcttgaatgg ttccaattgg gcgaataaga 2352301 gctacggcta caagcaatcc gataaatgtc agcttaattg gcgtcaaaaa tttaccaact 2352361 atatcaatga tttttgaagg attgagtgat aacaagcatg ccaatgcgaa aaataatatt 2352421 gtaaatatga tcaatgagac agggcttgca tcatttgata aaaaaggttt taccccaatt 2352481 tcaaacgata cgtttcctga tctcgggata gcgaaaaaag gcccgattgc caaatagaga 2352541 atcgtcgtaa atacaatgcc aaacaccggg tgaacacggc tggctaacga ctgtaagttt 2352601 tgtttacccg aaaaaacaaa tgctgttata gccagtaatg gcaatccaac tccggtcact 2352661 aagaaacctg cattagcgac ccatacattt ttcccggcca attgaccaag cataggcgga 2352721 aaaatgagat ttcctgctcc aaaaaacaat gcaaatagca ttaatcctat aatgatgata 2352781 taggaagcag acactttttt tgacattata tatcctccga ttaaagtaga cacttcttga 2352841 atagccagga aacattacag atgctatttg cactggcaca gtgttgattc caaaataagc 2352901 ttgtgtcagt tttatatatt tttatcaagt taaataaaag catgatcatt ttgatcgttt 2352961 ccgatatcgg ttaaaaaacc aattgcacca aaaccatata aacaacggtt ccccccgcta 2353021 tggaaagaag catatttttc ttccacaagt gaagcagtac aacagcagct gctccaacca 2353081 attcaggaat gccatgactt ccagaaagta gactcacatc tttcaaacaa taaatgacta 2353141 aaagcccgat taccgctgat ggcagcactt taccaagata ctgtacatat ttcggtgtcg 2353201 gtttgccaga cgggaaaatc atgaatggaa ggaaccgtgt cagcattgtt ccaagcacga 2353261 ccattgcgat ggtgatcatt tgctgcgtca tagtcatcgt catacggaaa cctcagcttt 2353321 ctccaatggt tttctcagaa cagtcagtac ccctaaaatg gcgagcatag caggaataat 2353381 aaattggttt ccgccaaaaa ggataagact ggctactgaa agtccaagtc ccgtgagagc 2353441 actgtaatgc tttttctctt tcatccattg ttctatgaat atcacaataa acagagcagt 2353501 catcacaaaa tcaagccctt cggtattaaa cttcacgtac gacccaaaaa tacctcctat 2353561 cgctgccccc gcgacccaat ataaatgatt aagcagtgtc acaaaaaaca taaaccagcc 2353621 cttatcaaca ttcgccggaa cattagcggt ataattgata gaaaatgatt catcgcacat 2353681 tccgaaaatc agataaagct ttttctttcc agtccccctg tacttatcca acatggaaat 2353741 tccataaaac aaatgccggg cattgaccat taacgtcaaa aaaagagcat tcatagggtt 2353801 gaacgcacca agtaaaaaat tcgctgcaac aaactccatt gagcccgcaa atatcataaa 2353861 actcatgatg attggataga ttgcgctaaa tcccaaagaa tgcataaaga tcccataagc 2353921 tatccccaaa aataaaaacc ccgcaaaaat cggaatggta tatgggaatg cagaacgaaa 2353981 tgcagcccat atttgacttc tcttattcat atgagtgttt atagcaggag agcttaaatg 2354041 taacgattct ttatttttat tcaaatcaac aacctcctac atttcatcaa ttggcacact 2354101 gacagttctt ttttctgtac tcatgactat gcttgtgtca actccactaa tagcagggtt 2354161 ctgcattaat gaatcaatga taaaattccg ataactctcc atgtccttcg ccacaatctt 2354221 aagcatatag tcatggcttc ctgtaagtgt gtagcattct tgaacctgtg ggaatttgtt 2354281 tatatcctct aaaaatgaat gaattgtctc cctatttaag ggtgataagt tgatgagagc 2354341 tagtgctgtg acttcgattc caagtttttt ctcatcaaca atagtcgtaa actttttaat 2354401 tatacctgct tctactaggt tctttgttct tgcaaggcaa gctgatggtg aaagcccaat 2354461 tttcttagat aaatttaaat ttgatattga agcatcttcc tgcaaatctc ttaagatggc 2354521 cttatcagtt tcgtcaagca taatacccat ttcacaaccc ccaatacaac ttaacagaat 2354581 tatatttcat acaatttaaa taataacgaa tttttattcg ttaatcaaat attatttaaa 2354641 tttaaatcct tttaaagtat tattcacaga ataaaattat cctcgcgatt aactcataat 2354701 gaaattaact tacatcagaa agaagtcatg ggagagttat gtacttgtgt gacttgatac 2354761 caacatcata agaaacttat cagaagccaa aaagttattg cggtctcacc gaaaattgaa 2354821 tttgcggtgc cctattgcct ttttccgcga acgaaaattg ttaaaattcg caaaacagaa 2354881 agtctactct attattattt taaattcgtc ctttagttct tcttgagcct cttgtataac 2354941 ttctaataca tcgtcagcgt atgaacctaa aaatgtattg ctgaactcaa aatttttcaa 2355001 gactaaagtg agcggcaaat ccacccaccc tgtcaggcaa tcccataaag cgtctaaatt 2355061 tctcccatag tagtctggga agtctagttt atcttttaaa tcatcatgta aaacttctat 2355121 attttcaaag tctcttccat ctattattat ttttctcatt agaaactatg ccctccatta 2355181 ttttatctta acaaacgttt actatgtaac agctgtttgt ccaaatgagg ctgaaaacaa 2355241 ataaaaaaca ccgataggat gaaactattg gtgtttgcaa gacatcttca tacccggtag 2355301 gcataaataa tgctaaactt tgtttttaaa aagctatcat atcaaatttt tatgttacag 2355361 cttttactat cgtttaatct aattgaggag taaaacaaga tatgtttgaa aatcacatat 2355421 cccctaaaaa ttaaaaacta atcggcagtt cttcgagtgc tctcatcaga aaattccctt 2355481 tccatttcat ttgtttcttt tcgcctttta actgtatatt tggacagcgg cgtaataagg 2355541 tggaaatcgc aatctttgct tctaagcggg ctagctgtgc accaagacaa aaatgattgc 2355601 catggccaaa agcaatatgg cggttgttct ttctttcaat atcaaatatg tcggcatttg 2355661 gaaatatctt ttcatcacgg tttgctgatg ctaaagaaat gatgatcaca tctttccgtt 2355721 taatctcctg cccatgcagt ataaacggtt cagccgtcca gcgaattgtc gttagctcaa 2355781 cagggctgtg aaaccgcaat gcttcttcta tggctgaatt catcaagtcc ggctgctggc 2355841 ggagcttttc tagttgatca tggtgacaca tcagagcata tgtcatattg gtgattaagt 2355901 ttacggttgt ttcatgacct gcaacgataa gcagcataat catcgagtac aattcttctg 2355961 tacttaattg tgtgccttca ctttccgctt gaattaatgc actgattaaa tctcctgcag 2356021 gttctctcct ttttttgcga actaaggatt ccagatattc aacaaactcc cctaacaagt 2356081 ggtcattctc ctgaagtctt tcaggggcat ctgaaaaatc aataattgct tgcgaccata 2356141 ctctgaattt ttgacgatct tccaagggaa tgccgagcat ttcacttatc acgataatcg 2356201 gcaatggaaa cgcataatcg tctactaggt tcatgaattt gttgggctgc actttatcca 2356261 ataaagaatc tgcgatatgc tggattttgt cttccaactg caaaatcatc cgatgcgtaa 2356321 atgctttttg aacaagagtt cgcaagcggt tgtgatcagg gggatctgaa ttaagcatat 2356381 gttttgttaa agtctcttca ttcttcaata gagcaggacg tttttctttt gcggtaaata 2356441 cattttcata gtttttcttt aatttttcat tctttaataa atgtattgca tcatcatatc 2356501 tcgatatgag ccagcctttc cccagagctc ctaaagataa tgggtagaga gcctgtgatt 2356561 ttcgcaattc tttataaaat tcatacgctt catctttaaa tgctctcgaa gacaattgac 2356621 tttccgtcaa aatggttaca ctcttttttt cttttgaaga cattcattcg acctccatct 2356681 ttgaaaggtt atgataatct ttaaatataa aatcaggacg atttgtaaaa tgatccattg 2356741 agatcagtat tcatgataag ggccaaaatg ccgtccccgc attttgaaat aaaagatatg 2356801 agacagtcat taatcatttt gctgcctaaa ctctttccct gataaaatgg cgaaactcct 2356861 aatacttcta tgccggctct tttaaggatt tggaaaattt tttagcccca ttttgattaa 2356921 tgttatcccc cctgctgcta tataatcgat caagtttaat gtcgggttta tcacgatgtt 2356981 ttaatagagc ggcaacaacc atttcaccat tctgaatgcc aacaaaaaag aaatgctttt 2357041 taaaatatgc tcttgtcagt actttatgca tttcaaaaat aaatgaatga tctttttttc 2357101 gcgttttacg agtaaatcca taaaaggata ttgattgaaa gattgatgga atagctttgc 2357161 cactttgctt acttcatctg ctcttgcttg tcgataaaga aacattgatg cacctcctct 2357221 gagcagtaaa gcaggaaatc gaattaaagc gcccttccta ttggaaaggc gcctgccgtt 2357281 ttactgtgcc aaaatgtttt tcatcagtga gtttttataa aatcatttat taattgatca 2357341 gttgtcaata ttgtggcaaa ttcatcatgc aatgtagcta gagatatatt atgaatagtc 2357401 gccgcatcat aatatgtatc attttggtct ctcattccga aggctgctgt tgcatctgaa 2357461 atcaggtatg tatcaaaccc taaattacca ctcattcttg tggtggttga tacacagtga 2357521 ggcgtggtta aaccagttat gactacagtg gttatttcat ttaattttaa gaattcttct 2357581 aaattcgtac caataaagct gctatttact gtcttggtta taatgacttc ttcatccata 2357641 ggcttaacta tttcctttat tgcaaaccct tcattctttg gatggaataa agaatgaggt 2357701 ttatcagaag tgtgttgtat gtatatgact gtccatcctt tttctctcca taattctagt 2357761 attttactaa tgttttcttc cgcctttacg ttattccgtt ccccccattt tttatcatcg 2357821 aaggcttttt gtacatccac aatgattaaa gctttctttt cttccacaag ataccctcct 2357881 acgtagaatt tctatttatt actacattct aaatacaaat tttacttttg tacaattgtt 2357941 taatgatgaa tttcaaatga gcgccttctt tattggaaaa tgcgttctat actgcaactg 2358001 tgcccaagcc gttaaccttc aaatctaatc tgagaatcac tggctctaca gagaataata 2358061 aaaaacactc taataacgag tgctgaaatg aaaaactatt gatttagaag ccatttgata 2358121 cgctcagctg aaatgatgta gtggagtatt ataagacata aaaagacaat actaactggt 2358181 tttaaataac taaaataaag cgctgcaaca gccattgcaa agatcaataa ttcaataact 2358241 aaccttgtta ctccgtttac agctattaca gtttgtccgc ttcgactagg atcatgaggt 2358301 actgcaaata cagaccagac aatcataact gcaataggta aaaccaaagt taaaacatat 2358361 ttaaaataac cattaaagct tatccaagca tacaccccta aggagattag tgcagcaatt 2358421 tcaagggtga atcttaaaag taaattagtc tgattcagtt tttccaactc ctctataaaa 2358481 aacacccccg caggagatgc tctttctctg ctttatttca gcgtataaaa acttttctgt 2358541 tcttcctctt tagattctat tgtagttttc ggcgagatta cctctacttt tgaagagatg 2358601 ataccgactg ctgctgttac caatgctccg ataatagaac gatgataagt ataatgaaat 2358661 atgacaactt ttcccctcct attcagttaa ttatccaaat aatcaggaag ttgtctacaa 2358721 tttgcagaat ttgtcgaacg aagtaaagat tatacctggg aggctttact cattgtatga 2358781 attacagtaa ataaattgcc ttcccttttg agaagacgtt ccaactcagc tagactcttc 2358841 caataggctt ccttttggcg cagctgcttt tattcaaaaa ttgagcaaca cctgaatgtt 2358901 tcattggaat ttctgaacca tcgatcgctg ctgaatttgt tgcaaatgca tacgtaggag 2358961 tagtcgaatg gtggttgaaa aatgaaatgc cttccccacc tcgagtgatg gcagaaaaag 2359021 cgggggtttt gttagagagg aatctataga tatgtgtatc gaagatttga cagcattaaa 2359081 aattatactt acatcgttgg gaacaggcca acaataaagc ggaagaacgt tgtcatttga 2359141 agtggtttgg aataaaaatg attcgaatat gttcttatca ttgtaaacga acaaaaaaag 2359201 aacatgtttt gaaaaaagat tgatcaaaac atcttcttat atgttgtcat agcgtaactt 2359261 tttataaaaa ggttaattac attttcgggg cttccaaacc aaattttgcc cattcttctt 2359321 ttgctggacc ataaatacct ggaacagtta aacctgcttg tctcataaga acagtcattt 2359381 gtccccgatg gtggttttga tgttgaatta aaaacatcaa aagtgaaccg ttaggcattt 2359441 gttgtccaat aaagttgata cgttcttgaa gtgtatggtc agtccattgg gtttttaatg 2359501 cctgtacaaa tgcattactg gcttgatgat agctgtcagc tataaactga gcagaagttg 2359561 gaacaggata atcttcagct ggggcttgga acgttaagtc tgtgtttgag gtaatgatgc 2359621 caatggcagc aacagtatgc caagcaatac ggcctagagt ccaattttgt gaagttattt 2359681 cttgtttaag tgattcatca gtcagactat ttaatagttt ctgtgtagca tctgcttcga 2359741 actcccaaga tttcaaaaaa tggtctaagg tttgaaacac aaaaatcctc cttttcattc 2359801 ttttgttttt tcaatgtgct tataggttaa ttataatgcc tcctttcgtt aaaaagaaca 2359861 aaaatttcgg acaagaataa tcatagtaaa atgcgtagac attcttaaac gtaacgattt 2359921 acgcatcttt ttacaaacat ctgactactt ggtctccatt gtcagcgaga atcaaatatc 2359981 atatgaagac aatcctatat tcttatcact ttactgagca ataaatacct tccgtatact 2360041 tagtaatacc ttcatcgtaa tcaggatact tatatgcaag accttctgat acagcttttg 2360101 aatactttct aaataatgca tagcaagtaa ataaagactt ccacatttcc tgatacccat 2360161 tcacagaata tgtagacatg agttcctccc attctttatt tgaaaggtac cgcttcataa 2360221 atttatagtt cttccccata ctaaatgaat accctttctg agatgcgata tgccaggcca 2360281 tcattctcaa taaattagga cgtacaattt catttaaatg gtcaatggca aaaaggattt 2360341 catttcttgc tagtcctttt actacgtaag tcgaaaccat ccagaactca ttacagcaat 2360401 catcaaattc ccttgcagtc ggccttttta tccagtattg gcgatcattt ggggtcactt 2360461 tatagttgat gaacgaatcc ttatcaagca ataccttaac caaaccatcg ttattagcaa 2360521 aataatcttc tgcttcacga attggaataa gggttagatc taatttgttg ccatcctcaa 2360581 aaagaataat gtatgaaaac caattaccta attcgggagg aaaaagctcc atatcttctg 2360641 gtttttgcat cataatgcgc ttcccaaaga tttcgagcca ctgatcattt tctttaaaag 2360701 attctacatc agttacaaaa tacgagatgt cataatcttg gaagttgtca ggagggatat 2360761 ttctgtttgt acgtgaccct tccaaagtga ccaatcggat tctctcatcg ttcaaagcaa 2360821 agtccaaaaa aatgtccatc atttcctgct cacttcgcat tacatgttcc tccgtttcag 2360881 ccttaatatc taactgtaaa acgtcttata gattttttta ctcttgaatg tgatgtattc 2360941 ttctaagctt tattttacat gatgttctcc tatatatcat tcaatattaa gatgcaagac 2361001 atctcaaaat cagatatcaa ctatgacgga ctacatgaat attcagtttt ttgtagagcc 2361061 gccatgggac gacactatct ttgacacact ttaatccccc ctgctttatc gacatgttaa 2361121 ctggtatgag agattgacaa aaagaaggaa aacgatatat ttaagcgaat acgagttttt 2361181 gagtaaattt taaaatgaca cttttttcaa aaatcatgtc ttaacgggag gattcggtat 2361241 gaatgaattt atgaaaaagt tttctttaac aaaaccgatt attcaagctc caatggctgg 2361301 cggtattaca aagccccgac ttgcatctgc agtttcgaat caaggtgctc ttggcagctt 2361361 agcatcgggg tatcttacgc cagacctcct agaacaacaa ataaaagaaa tatttgagct 2361421 gacagacgct ccttttcaaa ttaatgtgtt tgttccgcta ggtctagaga tgccaccaaa 2361481 agatcagatt aaaaagtgga aagaaaacat accgttagct aatcaagtaa atcaattcac 2361541 atctgtacaa gaagagtggg atgacttcta tcaaaaaatt gatctaattt taaaatacaa 2361601 ggttaaggct tgctcattca cttttgatct gccgcctgaa gacgcagtaa aggagctaaa 2361661 aaccgctgga tgctgtttaa taggaaccgc ttcaacagta gaagaagcat tgttaatgga 2361721 agaacgggga atggatatag tagtccttca aggaagtgaa gccggtggac atcgcggagc 2361781 attcttacct tccaaaggtg aatctgccgt aggtttaatg gctctgattc cacaagcagc 2361841 agatgcactg agcgtacctg tcatagctgc tgggggaatg atagaccaca gaggagtaaa 2361901 agcagcttta accctcggag cccaaggcgt tcaaatcggt tctgcctttt taatttgtca 2361961 cgagagtaac gcacatccag tgcataaaca gaaaatacta gaagcaaacg aagcagatac 2362021 aaagcttacg acattatttt caggtaaaga ggccagagga atcgtaaata aatggatgga 2362081 agaaaatgaa cagtttgaga cacaaaccct tccgtaccct tatcaaaata cactaacgaa 2362141 ggcaatgaga cagaaggctt cacttcaaaa taaccatgat cagatgtctt tatgggcagg 2362201 tcaagggata cggtcattga ctgaggaaat ttcggttaag cagcttttaa atcagctttg 2362261 ccaagaggat ataaaaatat aggcgcacct cattgataga gcaaaaagca aactttgaca 2362321 ggcagtttgc tttttttttc gtaatttcat ccactgactc tggaaatcta aatactccta 2362381 cattttcaaa gctaatttga atcgggttat caatcatcac attgatacga tgcgatcttg 2362441 ataatttcac cacaaccaca atacattacc aacatttcga tcttatctcc ccttctcaag 2362501 ttttgctccc tattcgaata atcgatagct cccatattaa atttgaatag taaaatggtt 2362561 ctttttcgtt tgattcagat gatataaagt catatgataa aaaaagaatg agacagaaag 2362621 cgtgagaagt gatgaaaata ggattttttg attcaggaat tggtggcatg actgtattgt 2362681 atgaggccat aaaagttctt ccttatgaag attacatttt ttatgcagat acgttaaacg 2362741 ttccatacgg tgaaaaatca aagggtaaag ttaaagaata tattttcaat gcagctgaat 2362801 ttctggccag tcaaaatatc aaagctcttg ttattgcgtg taatacagct actagcattg 2362861 cgatagagga tcttcggaga aacttcgact ttccgataat cggaatcgaa cccgctgtaa 2362921 agcctgctat aaataaatgt acagaggaaa gaaaaagagt tctggtagtt gctactaatt 2362981 tgacgcttaa agaagagaaa tttcataatc tagttaaaga aattgatcac catgaccttg 2363041 ttgattgctt agctcttcca ggactagttg aatttgctga gaactttgat tttagtgaag 2363101 acaaaatcat taaatatcta aagaacgaac tatcttcttt tgatctgaaa caatatggaa 2363161 cgattgtgtt aggatgcact cattttccgt ttttcaaaaa cagttttgaa aaactgtttg 2363221 ggataaaagt tgatatgatt tcaggcagtg tcggtactgc aaaacagttg aaaaaagttc 2363281 ttgcagatcg taaccagctt ggtaaaggat cgggctcaat cacctttttc aattctggcc 2363341 ataaaattgt ggaccaagaa gtcatatcaa agtacaaaag attgtttgaa atattagatg 2363401 aaactcaaag gagtcatgtt ggacattgaa tgtaaatgaa aaagacaatc tcctgaagag 2363461 aaacatgaac taagaagcgg gcttaaaaag cccacttttt ttctaacaaa caattgagtt 2363521 atacacacat atctgattac agtgttttct ctctttcccc tcttatttct cccccctctc 2363581 tatagctttt ctatttcaat aaaacacaag tctcgattga aaagttatcg taacatttac 2363641 acttcacagg agatttttca cgattgcgaa tcgaccgttt gccagatgca caaagtcata 2363701 atgtgtaaat tctgtatcta tgtgcatgtt tattatggaa ttattttcat aatgttttat 2363761 aatacaagat gatagcgttt tctaattata atgatagggg gaaataatga tgatgaaaaa 2363821 aggtctgctt gcgggtgcgc ttacggcaac cgtgcttttt ggcacatgtg cagtagatgt 2363881 accgggtatt attagtccaa aaaccgcaga agctgcatca cagctaactg atggaatcgg 2363941 cgggagggct tacttgaaca gtaatggtgc cattcttgtt acgaaaatcc agcttcctag 2364001 ctccactcag gtttcaaatg ggacagccta catctactct ggttttagcg gaggcacaga 2364061 atccgatatc gggtttcagt acagtgataa atataatgta tggaaaccat atatgaaagt 2364121 cggttcaaaa ggacaggatc aggttcagta cctcgaagga ggaagccaat tcacgaatac 2364181 gaaaggcttc cgtcccggca gcaccgtaca acttaccatc tacaaaaacc ttaacggcaa 2364241 tacccgcgct acatactggg gcacgaacaa tgccggatac aacggccgtc tcatttcaga 2364301 aatcagcaaa acaaatgtcg gctccatctc aaaatggaaa gcgctcgcta cagttgcaac 2364361 aacagggtca cgccaatcta tcaaatcaaa cttttcaaca tcttttacaa acatcaccat 2364421 cgacaacaaa gcaataacac ctgtaattga tacacaagac ttcgctaaag taacagtctc 2364481 aggcaacagt gtcagtttat ccgttgtcaa aaattaaaac atgttaaaca tacaatgcgt 2364541 taggctattg agaagctctc gatagtctta aagggggctt aacatgcccc ttttttcatt 2364601 tcaatttaac tttcagttag cttcggtaca tgccgtctat ccccgtcttt tatctgggtg 2364661 aagtaagggc agctcgcccc ttctgaacct gttccatttg ctcaacgcaa aaggtgtgca 2364721 tcactgtctt aaaaatgtta aaacaaatag cagatggtgc actttatttt tagatgaggc 2364781 atgcttacgc tcgatatgca agtcaaatga ttaagggtct gcaagagaga gaagttttgg 2364841 gtgtactttc ataaaagagg gatggcttca tatagctcga ttgcatcagg aagattagcc 2364901 aacgattggc cgagaacaac acatcacttt gaaacggatt cattccaaaa tcataagtat 2364961 gatccaataa ctaataaaga tcagttagca gtccagcctt aaaaatattt ttacatcaat 2365021 taaactagca tcactatcga ataagctcga tctgcatatc atgtactatc ctcttttaag 2365081 gaaggtgatg ttatgaggtc atttccatta atcgtagttc tattcatcct attaatcatc 2365141 gttgggacat ctttctttgg tggctattaa gaacacacct tacctcatat ccatcagacg 2365201 ccataagaaa tctttatggc gtctgttttt tattagattt aaacaaaacc attaaagtgg 2365261 gccatgcaaa cacacctatg gagattactg ccacgacttc tttgtgaggg aattattctt 2365321 ccctttatgg actattgtcg atcaaaagag aaagttgaaa tgcattttta tggtgagatg 2365381 aatcgaggct tagacatata aaaaaccgca aagctttctt gaagaagctt tgcggttttt 2365441 gggtctcttc tttgcttcat ataagccaat agatttcaag cgtaatccac tgccatacat 2365501 ccaatgattt tttattttga aataggtttc ttctactctt catgtgagat gactcaaggt 2365561 atgccacgtc acaataatat ggcggatact gaatggtctc aatcagtttt ttccccattc 2365621 tatcaattct ccacagaaaa aatggctatg gcagaacaac tttcatagag taatcatcat 2365681 ttaatgagcc atcatctcat gggcaatatc gtgtccatcc atttttgacg ggtagtaagt 2365741 aggccagttt ttgacttcat caagtaaagc ttcacggtcg tccccccaat agagatggta 2365801 atgactagct ttagtcgggt aaatactatg atcactaaac tgaatatact gaggcagccc 2365861 ttctgctttt ttagctagtt tgaatatgta tcttacccct ctattgcccg catcataggt 2365921 tagaatttcg tatccgtcat acgtatactt accagaatat tcttttccat ttttgaagaa 2365981 cgttacagta tctttctgga ttacaatacg gtcaacatct gtttgatagc cttttttata 2366041 atactcttta tattcttcag ctgtcttgcc gccttcgtgt tctgatttat atgaaaacac 2366101 ttcgtcaaga gtaccatctt gcaggtatgg atatacagat tgccaatctc cttcccaatc 2366161 agaaagtaag cgatccttta cttggctgtt tttaaaatag ccttcatata ttttttctgt 2366221 ttcttcatca tgcgcatgac tatgatcgtg agaatgttcg tgtgtatgac tgtcagatgt 2366281 ttgctcttgc gttttggaag agtcttcttc aactgctgag gatgatgttg tttgattaga 2366341 ctcacctgca gaagaaccgg aagtctgaca tcctgccaaa actagtaatg aaccaatcgt 2366401 taatatgcct agccgttttg aaaataaaat gttcattcca acactccttt tttattaaat 2366461 cgaaaacatt acgatttatt atacatacat ctcttgcaaa catcaaagga aaaatgctct 2366521 tcatgcggat ggcctatttt aaaggaataa ctgactatgt tcatcagtta ttcctttaaa 2366581 atacgaaagt ctacgatatt tccatatcga tccgcttcaa tgtgacagca cccctcaagc 2366641 agctgtttta attttccacg tccgcgttgt acccttgatt ttgctccgga gtaagaaatg 2366701 ccgagctttt cactcaactc tttttgtgat aacccctgga aatcagttaa ctcgagcgcc 2366761 tctcgatact tttcaggcaa ccgtttgatg gtcgatcgaa tacacacagt tgcttccttg 2366821 gtgaaatttt cttcctctgc actgtcatta aaatgtagaa catcaggcaa tatttcgctt 2366881 gttttttttg tacggtaaaa atcaataatc gtatttctag tgatccgata aatccagctg 2366941 tcgatctttt gttcatcgat cagatttggg agatgcactt gtattttcat aaatacgatt 2367001 tgcaagaggt catcaacgat agattgatcg ttaaccctat gtgaaatata tgtttttaac 2367061 ggctgatgaa attgatccca tagatcctct atattcattt gaaaaaacct cctataattt 2367121 tgcgtctgct ttacatttgc ttcgtctttt taatcgtaac aaagagcaaa caattgttga 2367181 atcaattgta ttgcagctgt tgccaaaaat aatgataaag gagaggtttg ttgtggagta 2367241 tacctattta gggagaacag gattgcgggt gagccgttta tgtttaggca cgatgaattt 2367301 tggagttgat acagacgaaa agactgcgtt ccgtatcatg gatgaagcac ttgataacgg 2367361 cattcaattt tttgatactg ccaatattta cggctggggc aaaaacgcag gattgacaga 2367421 gagcatcatt ggaaaatggt ttgcacaagg aggacagcgc cgcgagaaag ttgttctggc 2367481 gacaaaagta tatgaaccga tttctgatcc gaatgacgga ccaaatgata tgaggggctt 2367541 gtctctatac aaaatcagac gtcatctgga aggatcactg aagcggcttc agacagatca 2367601 tatcgaattg taccaaatgc atcatatcga taggcggaca ccgtgggatg agatatggga 2367661 agcttttgag actcaggttc gctccggcaa agtagactat attggatcca gtaattttgc 2367721 aggctggcat ttagttaaag cgcaagctga agctgaaaaa cggcgattca tgggactcgt 2367781 cactgaacag cataagtata gtttattaga acgaacagct gaaatggaag tgctgccggc 2367841 tgcacgggat cttggtttag gagtagtggc gtggagtccc cttgcaggag ggcttcttgg 2367901 cgggaaggca ttgaaaagca atgccggaac tcgtacagca aaaagagcag atttaattga 2367961 aaaacatcgt ttgcaactcg agaaattttc agatttatgc aaagaactag gagaaaaaga 2368021 agcaaatgtg gctttggcat gggtgctggc aaatccagtt ttaactgcgc cgatcatcgg 2368081 accacgaacg gttgagcagc tgcgtgatac gataaaagcc gttgaaatca gtctggataa 2368141 ggagattctc cgcatgttaa atgatatctt tcccggacct ggaggagaga cacctgaggc 2368201 atacgcctgg tgatacattc attactcaat actgacattt ttcttaaata tttatactga 2368261 actatcatat taagaaagac aagagcatgt ttgtctcttg tcttttccac atcgtgctga 2368321 aaatgctggc taaacatcga caaaaatgct gccgcttaaa aaagaaccct aaacaataga 2368381 gtaactggaa agacaactgg cttgatcagc ttgggacccc tttcagctgt atttaaatca 2368441 atcaaactaa tgattcattg gcagtctaaa tattattatt gtttctttac aaaatagtaa 2368501 tagcccctgt aatgattgct aacaacgtaa taactaatga tgtaattaca gcccacttaa 2368561 cggcaaacct ttgaaatgac cccaagtcca ttttaagcat gcttactagc aatactgttg 2368621 acgcaaccaa tggactcatc agatgaaccg gctgccccat tatagaagcc cttgcaattt 2368681 ctactggttc tataccatat gctgaggcag cttctgcaaa gataggtacc ataccaaagt 2368741 aatatgcatc atttgataaa acaaaagtaa acggaatact agtgagtgct acaataacgg 2368801 ggaaaaaccc tcccattgat gaggggatga tggatattaa tgatcctgct atggcatcca 2368861 ccatctttgt cccggataat ataccagcaa atactcctgc tgaaaatacc aataatacca 2368921 cggttatggc attaccagaa tgctcggcga ttcgctcctt ctgcattttt acattcggat 2368981 aatttatagt aagggcaaga acaaaaccaa ttaaaaataa aactgacgga tgcttagttc 2369041 caagcacaat aaacaccatg atacttataa cgaggaataa attaagatat attaagcgtg 2369101 gccttttcaa ttgttcgctc tccaaagtag cagccatata agattgagag ctgtcctttg 2369161 ttatatgtct aggctctaat tgaacgatgc ctattcgatt cctctctttc cttcccatta 2369221 gaaaagccag aaatatcaca caagcaatac ctccaagcat ggtcggaagt aatggcacaa 2369281 agaaatctga aggatccaaa cccagcactg aaatcgctct tgtagctggt ccgccccatg 2369341 gagtcattcc gctaacgata ctcaacgaca gcattgctaa tgtcgccata accatgggat 2369401 tcataccaat tcttttatac aaaggtaaca ttgctgagac tgttatcata taggttgttg 2369461 taccgtcccc atctaaagcg ataagcattg ccaagacggc agaccctatc gctattttca 2369521 cagggtctcc ctttactata gataaaattt tttctattag cggatcaaat aaacctgcat 2369581 caattaaaat tccgaaaaaa agaatagcaa acaatagcaa tgccgctgaa cttgcaactg 2369641 tttgaattcc ttctaaaatc atgtcgccaa tacccttacc aaaacctcca ataagagcaa 2369701 aaacaatggg agtgatggtc aaggcaacaa taggcgagac tttctttgtc attattaata 2369761 ttgtaaaaac agttaccatc gaaaaaccta aaatagtaag catattacac ctccaagaat 2369821 gcgctttcaa atgacttttg attaacatat cttatacggt gtaataagtt aaataaatat 2369881 ttttttactg tgtttcaaaa aaaattctat cataacttta aatggttacc atttgttcac 2369941 cctttaaaaa atcaatgaat gctttaacga gtttgattcc taatgatttt tgatcgtaca 2370001 ttagccaagt atctctcatt agaggcttac ccttagcatt atacagttcc attgtgtaca 2370061 aatgatcaga ttcctgcagg caaatttctg gtgctatgga gtaaccaaga ccatgcttta 2370121 ccatctcttt gcaagtctct tgtcgatcca cttccattgc aataatgggg gcttgtttta 2370181 gattcgtatg catccaatct tctataatcg tttttaaaga agcatccgtt ttatatttga 2370241 taaaaggtaa aaaaggaagt tgctctatcg ttattggttt ttttgagatg atatgtaatt 2370301 tttcccgtgt cagccgttcc tccacccctt tccagcgatg gcttcctctc agtataccga 2370361 cttgtacaat accagcatct aataatttca tgacatctgt gctccagcct gtttgtacac 2370421 tatattggac attaggatac atagtggaaa attcccttaa taacttaggg agcttatatt 2370481 gagcgaaatt gcttgatacc cccagcctta gatgtccttg cacctctttg cttagattag 2370541 agatatgatc tttggtatct tgaagttcct gtagcattct tcttgcataa gcaaccaagt 2370601 gttctccttc cgcagtaaag gtaattcctt tatgcctttt ggtgaataat tcaattccga 2370661 aaatctcctc aatctttttc aaccgataag tgatggaagg ctgtgatgta aataatcgtt 2370721 ctgctgtttt tgttacactt tgttcttcgt gaagaatttt caataaaatc caatctttct 2370781 catccatttt catcttcctt tctagtcctt ctttcacaat tataaaagtt tttttatcga 2370841 atattaagaa aacttatatt ttatttttat ttttttacct tctacactaa aaaacataaa 2370901 aaatactacc tttaagatga ggatgatgac gatggtcaag acgaatgtaa caatcatgag 2370961 aggcggaaca agcaaaggcg tttttttcca cgaatcagcc atgcctaaca ataaaaacga 2371021 atgggagccc tttttgcttg atgtcatggg aagtcctgat aaaagacaaa tagatggttt 2371081 gggtggcggt aattccctta ctagtaaagt ggcaataata aagaaagcat atacttcgga 2371141 tattgatgtt cactatactt tcggtcaagt cagcatttcg gaagaaaagg tggactttaa 2371201 ggggaactgc ggaaatatct ccgctgctgt tggtccattt gctattgaag aaggacttgt 2371261 aaaagcgaaa gaaccaatga ctgcggtaag gatcctgaat accaatacga ataaaatgat 2371321 cattgcggaa gtagaagtgg aagacggtca ggtcaaatat gacggagatg ttacgatatc 2371381 tggagtacct ggatctggat ctccaatcta tttaaacttt catgatgccg ctggttcagt 2371441 taccggtcat ttattgccta ctggaaatag ttcggagttt ttagatacaa gtcaaggcca 2371501 aatagaggtg tctattatcg actatgcaaa tccattagtt tttgtggaag cgagcagtat 2371561 cggcctggat ggaacggaac ttgcagaaga atttactgat ctacagttgg ctcaatttga 2371621 agaattaaga tccattgcgg cagagaaatg cggctttgcc agtcgatttt cagctacaaa 2371681 gttatcgccg gctgtcccca aactggctat agtagcaaaa ccagagaaat ataaagatag 2371741 tacaggtgct tggcattcaa gcgttgagat ggacttacac atcaggatga tgtccatgca 2371801 aaagccacat caagcactgg ctgtcactgg agcgatatgt acaacaagag ccctttcagt 2371861 ggaaggtgca atccctgcaa gaatagcaaa aaaccactct acaaaggttc ggctagctca 2371921 ttcttctggt attattgaaa caatggtgga gcccactggt ataaagatcg tccgtaccgc 2371981 acgacgtatt atggacggaa cagtttatac gcatggagac tatcaaatga tgtagatgga 2372041 ctgtgcaaaa agcctccccc ctttccatcg ttaatagatg gattgaatgc gccttcttgc 2372101 acagatccat tgtaatcttg catggcttta aaaaagcctc tatattgttt tttatgaaat 2372161 cgccaaggtc ctttcatgta tctgcctcaa gcatgacata atcattatag agaaaattga 2372221 atacttttta ctgcaaataa aaagatacca acatcattgg tatcttttag attgagttca 2372281 tctgcagcgg tttcttttcc tcactgctta tttgattaca aaattaccgt actcgtttga 2372341 acgaacatga atcggtccgt ttagattata gttgttctcc ttggcgatag agcgaagcac 2372401 gtccacacgg gcaactgatt ctctccattc gtcacgggtg tcatgattgg ccggattcat 2372461 cagatcgtca tagcgtacgt ccaagaattt attcaaccac ttcttctcgt ctattccgtc 2372521 tttaggtgat ccgcccgctt ttttgttcgt acgtttaatc aaggcataaa aagagtcagg 2372581 gtcatcacca tcgccatgct gaataaccgt atcgtacatc acagctcttg ccaatgctgt 2372641 ttttagtccg gcattatccg atcgtttcat ggcaggctga taatacaaat ggtcatttac 2372701 tttgtcttga gcggcgcgaa attccttatc atttgcaagc gacttccagg cagaagcgaa 2372761 tcccttgaga ttgcttgtat catcgctttc ttccttggcc agacggcgca attcaggcag 2372821 atactttttc agtttgttat tcggaactgc ctttgtgtat acttccacta cttccaatgc 2372881 atccccggta gccgttgtaa agcctgcccg tccgcatgta tagcctcgcc cgtcatccaa 2372941 tcgctctaca tatccatatt ggatctccgt tgtgccgttt tcaaagatac ttgtcagctg 2373001 ttccgcccgg cgcttttgat ctttattcag tcccgccgca aaaaccgttt cgctcatcat 2373061 cagggtaaaa aacatggtga aaacaagtaa tgagatcgct gcttttttcc aaaaatctgc 2373121 tttttgcata ctgattttca tttcacttcc cctttctaaa tattgtaaat acagactcag 2373181 tatacatgaa gaaactgccc tattgttgaa aatacatcaa tttgtcaata ttttgaatct 2373241 aaagtaatat agcttgaatc ttactctatt cattgccaat cagccttagc ccctctcact 2373301 gggaaggtcc cttgattttc atactgcttc aactttcatt aacaagatgc cataaggctt 2373361 tactctattt tataatggaa gtgatcatcg aaaatcgtta gggaggtgat gtaatggcaa 2373421 gcaagatgag aatgccagat tccgcaacgt cccatgcaaa gcctactatt gggaaggcga 2373481 tactttgcat ggggtagact ttctaaaaga tcgcccaagt aagcttttct gatatagtgg 2373541 ctttgcacct tatttgacat aaaaaaataa ggagctggca gaaatggcat atgtaaaagc 2373601 aaccgctatt ttacctgaaa agctgatatc ggaaattcaa aagtatgttc aaggaaaaac 2373661 aatatatatc cctaaacctg aatcctctca tcaaaaatgg ggtgcgtgtt caggaacaag 2373721 aaagctgatc gatgacagaa acgcttctat taaaaaagca tttaaaaacg gcaaaaccat 2373781 tcatcaatta tctgatgaat atcacctctc tattgaaaca ataaaaaaaa ttgtctactc 2373841 taaataaaca aaacggaagc actgataaaa aataatcagt gctttttata tggcgagttt 2373901 gtttcttagt tatttcctgc atatgatacc attggccaat tgtgtaaagt taagggagat 2373961 gagaagaaag gaaggtccta caaatgacga taaacaatgg aacgttgcaa gtacccggcg 2374021 cgaacatcca ctatcaggtg cgtggctctg gtccaatcat tcttttggtc cacggaggag 2374081 gcggtgatgc cgacaagttc catcatgttg ccaatcatct ggctaactgg tacacggttg 2374141 ttacttatga tcgccgcggc cattcccgca gcaatctcgc caatcagatt gagggttacc 2374201 gtgtggaaac acacagtgac gatgctcacc gtcttctagc caaaatcacc aataagccgg 2374261 cctatgtatt tggaagcagc tccggggctg ttatcgggct tgatctgtgc atacgccatc 2374321 ccgaacaagt acatgtcatg atcccacacg aaccaatctt attgcagctt ctgcatggaa 2374381 atgagctgaa acaagccgag caattcatgg aagaccttaa gaaaaatcat cgaagtgaag 2374441 tcattaaatt aatgtcaaga ttagagacag acgaacaatc aaaggctgtc ctgacaaagc 2374501 ggcttctcgg caattcaacg tatttcactg agtatgaaat tcaaggaatt ctcagctata 2374561 cattagattt cgaagcatta aaaactgtgt ttacatcttc accgatgaag atactcccag 2374621 ctggcggaag tgcttctcgg gagctttttc cttatcgttg cgcgaacgcc ctagcggaac 2374681 aattggaaac agaatgggtt gaattccccg gaaatcatac ggggtacaca atgtaccata 2374741 aagaattttc tgagaggtta cacgacatgt tagaaaaaga aaagaaacat acgtgttaag 2374801 gattgattaa aattttcaaa ataggacagg tgaaactaac tatggaattg gagaagattt 2374861 cacgaagcgt aaaaagaact tttcactaac gagaacgcaa tgtgagatgt ttaaccaaag 2374921 tgatattagg gatttcatcg aaaaataggt ttgtacatta cgttctccta ttgattattt 2374981 cctatcttaa ttccgtattt tataccatta gatacaactc taaagcggct cgttattttg 2375041 tcctcaacaa caaccagtgt ctaacatcat gaatctcttt tgaaaatcac cacaaatgca 2375101 ggtatggaag acttcatcgc agcaaaaacc ataccaacta ttgttgttgg tatggttcgt 2375161 cctagatagg cccttaagaa gagattctat tgtacggagt atttagctaa ttgcatttgt 2375221 aaccgacagg gccgtctgaa cctgtgtaca catatgtgtc agacacatat ccaatattca 2375281 cgacaccccg ggaatctttc cactggattt ggtcccagat attactcgtt ccatacttcc 2375341 ctgtaacagt cgttccataa gcgtaacaat aataaggaac acgggagcca ctcggaatgg 2375401 aaagcataat aggataattt gtaccaggac cgctgcgcat attgacaggc gcaccgctgc 2375461 ttgttgagac agtaaagtac tgaacggcaa gtgcctgact ggaaaaaatg aataaagatg 2375521 caatcatcac ggttaacata ctcagcattt tcagtttagt caatgtcatc cctctttctt 2375581 caattccttc attttaagaa acgatagaac ataggctacc agctgcattt aggaacaacc 2375641 ggaccgtctg agcctgtata catatatgta tcagagacaa atccaggaac gatctccccg 2375701 ctggcaagcg tccgctctgt gtaattccaa atattgctcg ttccatactt tccagttaca 2375761 gttgtaccgg ttttgtagca atagatcggg atgcgggttc cgctcggaat ggtcgttaca 2375821 attccccaac ttgtacctgg gccgctgcgc atgttgacag gagcaccgct gcttgttgaa 2375881 accgtataat actgagccgc aagtgcatgg ctagaaaaaa tgaacacaga tgcaatcatc 2375941 accgttagca tacttagcct ctttaactta ttcaccttat accctcccct tataaatgcc 2376001 gtacgtttga ctttcttaca tccagttaag gatttacttt cagataccat gccccctccc 2376061 ctcccatata tttatcaatg taccataaac tagatctttc aaaagtggaa ttattcctat 2376121 gttttcgaca attaaggata caaaataaat ggtagtcagg cttgatattg atggtgtgtt 2376181 acatttggct cttaatcatt tgtccagtcg gtaatcacga ttgacaatca ggaaaaagga 2376241 catggatcaa gcggcttcgt ttccaccaat taactcaatc agtgtactgc ttccttgtat 2376301 ccacgcttct tctcgattca tagatactcc acctttttca ccaatcaaaa acggacacca 2376361 tacaaatcag cgtaaatgct gcaagttcag tgtccgcaac ctattatgac tttgctttct 2376421 tttaccaggg cgtgtaaaaa tgattaggta cgttatcaaa cgttattcta tgattttgcg 2376481 agtcaaaaaa tcataacatt ttatatattt caatcagatt atgatctgga tctctgaagt 2376541 gagcaactcg ggcactccat tccttgcgat catgcggttt attctcacat ttaactcctt 2376601 tttcgtgtaa atcgtcatac gttttatcaa catcttctac cttaaactga agcaaaaatt 2376661 ttgattgagc ttctccttcc aaggactttt tttcctctcc aacgatttca gccatcgttt 2376721 ctcgagataa aagctctatt ttcgtttccc cattatcaaa gagtgcatat tccatttcat 2376781 tctctaacca acttattgga agtcctaatg aatctttata aaactcgacg cttttcttaa 2376841 aatcattcac caacagtcta atttgtaaca gcttcatatc gagtgcctcc tataaaacca 2376901 tacttttact ggtcatccaa tttaatgata ccaaagaaac ctgacagcac tatgtcaagt 2376961 ttccatactt cacccttatt tcagatttaa gtgcagttta gtccatgtca taagaacgag 2377021 caaaaacagc gattcttaaa acaaaaaatg ataccgagtg tattttctgt atgcttcaac 2377081 ttcatttcgg gaaatgtaac gttgataaaa ggaggttaca tcaatatgga tcatcaaaca 2377141 ttggcagctc atgaggctgt tgacttacat gaaatcgtga actttaaaac actttgtata 2377201 gcgaaatcaa agttaatgca agggcttgtg tttgaccaag aactgaagga cttgatggaa 2377261 aaagatgtac agcaatccat tcaagacctt actgaattac aagcggttta tgagcgtgcc 2377321 tcatttcagg cccctgtccc tcaaagccgc ccaacgccaa tcatcaattg aaagggaggt 2377381 aagcctcttt gaataatgat catttagacc ccattaattc gctgaatgtg cctgaactag 2377441 cagacactac attcgcgatg gattttctta tacgagctaa ggaaggcgta aggaatactg 2377501 ctgtagcttt gacagaaacc gcttcaccag atgtaagagc actgcttcgg aaacagctga 2377561 tgcaaggaat tgcgatgcac caagagatta cggaactgat gatcagcaaa aagtggttcc 2377621 atccatatga gctgagcgaa cagtataagc tggatcagct ctctgcaaaa aacacgatca 2377681 tggtcggcaa tatgaacctc tttcctgatg aaacaaatcg caaagggatg tttgaccgga 2377741 cacctgatga acactaacac tggaggtttt acagcatgaa ggcagtaacg tatcaaggca 2377801 ttaaaaatgt tgttgtcaaa gatgtccccg atccaaagat tgaaaaatcc gatgacatga 2377861 ttatcaaagt caccagtaca gccatttgcg gatcagattt acatttaatc catggattca 2377921 ttccgaatat gcaagaagac tatgtcatcg gccatgaacc gatgggaatc gtcgaagaag 2377981 ttggttctgg ggtgactaaa ctaaaaaagg gagatcgggt aattattccc tttaatatag 2378041 catgcgggga atgctttttt tgtaaaaacc agctggaaag ccaatgtgat cagtctaatg 2378101 acaatgggga aatgggtgct tatttcggct attcagggca aactggcggt tatccaggcg 2378161 ggcaagctga atatttaaga gtgccgtttg cgaattttac ccattttaaa atccctgaat 2378221 cttgtgagga acccgatgag aaattaagcg tgattgccga tgccatgacc accggctttt 2378281 ggagtgtgga taatgccggc gtaaaaaaag gcgatacagt tatcgttctc ggctgcggac 2378341 cagtcggcct gtttgctcaa aagttttgtt ggctaaaagg cgcaaaacgc gtcatagcag 2378401 ttgactatgt aaactatcgc ttacagcatg cgaaacgtac aaacaaagta gaaatcgtta 2378461 attttgaaga ccatgagaat acagggaatt atttaaagga aatcacgaaa ggcggagcgg 2378521 atgtagtcat tgacgctgtt gggatggatg gtaaaatgag cgatctcgag ttccttgcca 2378581 gcggcttaaa gcttcatggc ggaacgatga gtgcattggt cattgcttcc caagctgttc 2378641 gcaaaggagg aaccatacaa attacaggtg tgtatggagg cagatataac ggttttccgt 2378701 taggagatat tatgcagcga aacgtcaata tacgctctgg acaggctcca gtgatccact 2378761 atatgccgta catgtttgaa ctagtatcga caggcaaaat tgatccggga gatgttgtca 2378821 gccatgtcct gccgcttagt gaagccaagc atggctatga catttttgat tcaaaaatgg 2378881 atgattgtat caaagttgtg ttaaagcctt aaaaaacgga ggttacagaa atggaatacg 2378941 ccttacacga agtgcttgag gttcaggaaa tgactgcatt taagacactt tgtttgacga 2379001 aatctaaaac aatgaaagca ctggtatctg atccgaagct gaaagaaatc atgcagcaag 2379061 atgttgatat caccacacgc cagttgcagg aatttgcctc tattttatct aatgcaaagc 2379121 aagaatgagg agatgaataa atcatgaatc ctatcataga atatctgact ggcatgaatg 2379181 ttctaacaga ccaaatcatt gctatggact tattaatttc agcaaagaac ggagtcagaa 2379241 attatgcgat ggcagccact gaagccggaa cgcctgaagt aaaagaggtc cttatccgcc 2379301 atttggaaga agcactcgat atgcacgaac aactctcaag ctatatgatg gaaaaaggct 2379361 ggtaccatcc ttggaaccct gacgaacaag tcaagctgaa tttaaaaaat attgatacag 2379421 ccattcaatt gccaaccctt taacatacaa tgactgattt gctgaggaac agtattgatt 2379481 ggccacaact gttcctcagc ttcaaaatga gcactgtttg ttcgggtcct atgaccgtaa 2379541 atagattaac cgcttttctc catctgatct ccgataatgt ttgcaaattc tccaatccaa 2379601 ataaggaatc gtaaccacct ctttttatgc gatctcttga tggagaaaac aggccagaaa 2379661 caaaatcctt cgtttttgac ctgccctctt cacacgcaaa gaatgctacc ttctttgctc 2379721 cactgatccg tgaagacttt ccgttttagg cctgcttttg agctttgcct cattttcacg 2379781 caatttccca tcataatctt taatttttgt gtctaatctc ttaattgttt catcaatttc 2379841 tttccgcttc tctatcagcc gctgtcgttc gtcagccagg atattttttc gagcttctac 2379901 cgtacggtca ccttcggtaa ataatgttgt atattcaatt agcgcttcta tcgatagtcc 2379961 cgcatttcgc atgcatttaa tgaattcaat ccatttgata tcttcttcat catagtcgcg 2380021 aatgccgctg tcttttcgtt ttacaggcgg gattaatcct acacgttcgt aatatcggag 2380081 tgttgcggct gtcaggccaa actgctttgc cacctgagca atattcatga tcttcacctc 2380141 tctatcctgt atgttgtgaa ggtaacactt aaagttaact ttaagtcaag ctcaaaacaa 2380201 gtggttagct gctgaatctg ggtttatata ttcgggactt gccttaaagc acactttaaa 2380261 ctctatactt ctccatgcac taaaaacagt gtagttggag ggattgctga atggcaaata 2380321 aacacactgc cggaagagaa caattaggag aatttgcgcc aaagtttgct gaacttcatg 2380381 atgatgttct attcggtgac atttgggcaa gagaagaaga actttcatcc cgggatcgca 2380441 gcatgattac agtttctgca ttaattactg actgtttctc agcttataaa tcaggttcat 2380501 tttaaatggt ttttttaaaa aacccttgcc ttaaagcaga ctttaaggtt tatcgttatg 2380561 ttgaagacac cataaaacat aaataagtgc atgtttttat ttacaacact tatgatgaag 2380621 aaaggatagg ttcgtatgtg taatcaacat caaacccgtg tattaagcgt gtcacatgca 2380681 aaagccaaat ttgaacaaac gacgattgag cgaagaggat tacggccgca cgatgtctta 2380741 atcgatatta aattcagcgg catttgccat tcagacattc atagcgcttt tgatgaatgg 2380801 ggcggtggca tcttcccaat ggtgcctgga catgaaatag ccggtgttgt aacagccgtt 2380861 ggaacaaaag tcaccaagtt ggctgtcggg gaccgcgttg gtgtcggctg ttttgttgac 2380921 tcttgcggag aatgcgaata ctgtctcaac gcagaggaac aattctgcac gaagggtgtt 2380981 gttcaaacgt ataactcagt agactacgac ggaaacccca cttatggcgg gtacagccaa 2381041 aaaatcgttg tcactgacag atttgttgtt cgcataccag atcgtttgga aatggatgtt 2381101 gccagtccgc tgttgtgtgc aggtatcaca acgtattccc cgctgaaaca ctggaatgtt 2381161 ggccctggta aaaaggttgc gattgtaggc gtaggtggcc ttggacattt ggcaattcaa 2381221 tttgcacatg cgatgggtgc agaagtaacc gtcctgagcc gttccatgaa taagaaagag 2381281 gaagctctgg aactcggtgc aaatcattac tttgcaacaa gtgacccagc cacattcact 2381341 gcattggccg ggcgttttga cgtgatctta aatacggtat cggcaaatct cgatgtagat 2381401 gcctatttat caatgcttcg tatagacggg acacttgtaa gcgttggagc tcctgccaag 2381461 ccggacacat acagtgtgtt ttccctaatc atggggcgcc gcagcattgc aggttctcta 2381521 gtcggcggaa ttcaagaaac tcaagagatg ctggatttcg cagctgagca tggcatcgaa 2381581 cctaaaatcg aagtcatcgg agctgaccaa gtggacgagg catacgaacg tatcctccga 2381641 agcgatgtcc gttatcgatt tgtgattgat atttccacat tgtaataggt tagtccttat 2381701 atgggctgcc gcttttattg aaactcacga aaaatgatct ctttaagcaa atattttgaa 2381761 ggccggtcaa tcttcctgtt attctatgaa tagagagtta ttaggagggt tttttatgag 2381821 caaaaaaatt gcagttcttg ttacagacca attcgaagac atcgaatata caagtccggt 2381881 aaaagcatac gaagaagctg gctacagtgt tgtggctatc gatttggaag ccggcaaaga 2381941 agttaccggt aagcatggcg agaaagtaaa gattgacaaa gccatctctg atgtggatgc 2382001 aagtgacttt gatgcacttt taattcctgg gggattctct ccggatttgc ttcgtgcaga 2382061 tgaccgtccg ggtgaattcg caaaagcatt tgtcgaaaac aaaaaacctg ttttcgcaat 2382121 ttgccacggc ccgcaagtac tgattgatac ggatcttcta aaaggcaaag atatcacagg 2382181 ctaccgcagc atccgcaaag atttaatcaa tgccggtgca aactacaaag atgcagaagt 2382241 agtcgtcagc cacaacattg tcacaagcag aacacctgat gatttggaag catttaaccg 2382301 cgaatcttta aacttgttaa aataacaaga aggcacagac tgttcgggtc tgtgcctttt 2382361 ttaaaattaa gactccttcg ttacattctg aaagacagca gtcgcgtccc acacattcaa 2382421 gccaaattgg ccttctgaaa atacggaatc atgtgcatca atcacaagac gatcatctaa 2382481 atagatttta aagcgatcgc cctcggcctc tgttttcaga tgatactttt tattaacgtc 2382541 tatcggtgtt ttgtattcag caatgacaga agcagcaccg ttctcaaatt taaagaattt 2382601 cactaggtca tgcttcgcat ccacattggc aaggtaaccg tttttggcat ctttgtcaga 2382661 gcgaaacatt agtgctcctg cccctcttcc gtttccatcc ttaatggtga tatcagattc 2382721 ataagtgaag tctgacccgg atgctgaaga caagataaag gaatcgccgt ccgacctccc 2382781 ttgtttcccc tcaattgtgt ctgcccacgt gccatttaca gtcgtccagc cagtcatatt 2382841 ggacataaaa ggtgtcgttc cccatacctt ttttaaaggg tgtatcgtta aagattttac 2382901 ctttacaccg ccatttgcag catataattc aagccctttg cttgatcggt ctgggagaat 2382961 aatatccgtt atgacctgct ttccgtcatt cccaaatact tcaaccgagg agcggtcaac 2383021 aaaaatgcgc aacttaacct tcccatttac cggcttcaac ggggctgttt cttttccggt 2383081 gttaaaggcc ggattaaagg tgtcgttgcc tgactcgctc cggtcaacga acaatttggc 2383141 gttccttcgg tcatagccga ccttcgtaaa ttgattttca cctgttcgga ccttaaaacc 2383201 aaattcagca gctgaaccag ggcttacttt aaattctgca tttatttcat aggcatctcc 2383261 agattgcccc gctaacacat tatgacttgc aggcgatatg gtcagattct tccacttctt 2383321 agaggttccg cgaatggttt ccagctcttt caccggtgtt tggaccactc taaccccttc 2383381 ggtaaacgct ttcaatttta actctcttgg aatggacgtt gcacttctcc atggggatgt 2383441 cggaacatca ttcgcatatt gccaattgct catccaccct aaccatagcc ggcggctgtc 2383501 tgtggatgga atatcagacc aggatacagc cgcataaaag tctctgccgt aatccgtcca 2383561 gagaactttg tttggcgggt tttcattttt aaaatgagtt ccatcaaagt cccctacaaa 2383621 atattgcatg cctgatcctc ccgagaccgc tccgtttccg acactgacct gcatgaccca 2383681 tttcttttga ttcggattgc cgtctaccgg aagctcaaat aaatccgggc attcccatac 2383741 tcccccgtgg cttccttgat cctgtccaaa ttcacttgca tacgtccact gcttcagatt 2383801 ttttgatgta taaatgagga ttcggtcacc ggccgcaagc accatcaccc actttttttc 2383861 tttctcatac caaaagactt ttggatcgcg aaaatctttt ttacccgggt ttggaatgac 2383921 agggttgcca gcgtacttcg tccatgttct tcctttgtcg ttgctatagg caatactttg 2383981 cacttgatgg ccttcccgat cctgtgtata aatggccaca agcggcttct ctttgcctgt 2384041 ttgaaaaccg cttgtgttat ttttatctac aactgcgctt ccagaaaaga tcgtgccttt 2384101 ttcatccgga tacagcgcaa caggaaggtg ttcccatgta accaaatctt tgctgacggc 2384161 atgcccccaa tgcatgggcc cccactgaag cccgtatgga tggtattgat agaacaagtg 2384221 atattcccca gcataatata ccattccgtt tgggtcattc atccagtttg cctccggtgt 2384281 gaagtgatat tgaggacggt aatcctcatc atagtagctt gaatcggctg catctgccga 2384341 aaatgccata gtcaacagca gggtgaacat gatcatgact tgaatcagtc tctttttcat 2384401 ttgttccttc gctcctctct tcatgtttga acactttcaa aagagactgc tgcgcaagct 2384461 ggtccgtttc tggcaattct cctctgtttc actgttatcc gaatgattta tatatgaaaa 2384521 gactgctgca gtttctctct ctttccttca cacaccttat gctaagaatc cagcccaata 2384581 cccgagaatc ccgatgacaa agatgccgca aataatgaga agtggattca cccctttgcg 2384641 aagcatccat gccaccaata acgttaatcc gagaggcagc gcccccggca taatgctatc 2384701 tagcacgttt tgtaccgttt gaacatctac ttttccgctt tcatccttaa tcctggatac 2384761 aacgattgga atgttgatgg tggtccattt ggacacgaga gcccccataa caaataaccc 2384821 gagaatcgaa gcgccctctg taagcttttg aatgcgattc cccgctaaat cctgaagaat 2384881 ctccattcct ttcacatagc catactttaa tccgtaatat tttgtgctta atcttatggc 2384941 attcagcaag aaaaagaata gcaaaggacc ggcaatgttt cctcctaaag caagggaggc 2385001 tcctagcgca gctaagacag gacgaatcgt tccccaaaaa attggatcgc ctacgcccgc 2385061 tattggtccc atcaaaccga ttttcattcc gcttatcgct tttccgtcaa ttcctttatt 2385121 gttcgccatt tcttcttcca tggctgccgt cacgccaaat ataggcgctg tcagccacgg 2385181 atgtgtatta aaccattcca aatgccgctg taaggcttcg tttcttttcg ctccgggacc 2385241 gtacaatttt ttgatcgccg gtatcatgac ataacaatat cccattgcct gcacacgttc 2385301 gaagttaaag gaaccgagta aaaaatttga acgaataaac atgctgaaaa tttctttctt 2385361 cgttaatcgt ttttctttct ccattttttc ttccccctca tcgtttaggc atcaagatca 2385421 tcatcatcgt catcataaac agcaacactg ccactgtctg atgcggccgc gactgctccg 2385481 tgagcgcttt gtttttgcat cacctgctgg tataaaagcg ccagacagag accaagggct 2385541 ccaaatccca ctaagttaaa atcggtaaac gccgctaata agaaaccaat atagaaaaat 2385601 ggctttaaat aaggaatatt catcatattg atcaccatgg catacccgac aaccacaata 2385661 atgcctccgc ctatttgcag tccttttgta atgacatcag gaatatttcc caggaacgcc 2385721 tgaacagcgc tgacactaat taaagcaaca atcaatgtag gaatcatgac gcgcaaagct 2385781 tgaaacacca tcgcggtaat atgcataatt tcaattcctt ttatatttcc cgcttttgca 2385841 tattgatcag cgcggtggat gaaaaagaca gtgatcgtcc gaacaaaaat cgtcagcgcc 2385901 tgacccgcag ctgctaaagc aacagcgaca gcaatccctt cgccaattcc ttgatcagcg 2385961 gtaataacta aaatggttga gatgacagag gcgatcgctg tatcaggtgc catggcaagc 2386021 ccgacgttca tccagccgag cgccatcagc tccagtgtgc ctccaagaat aattcccgtt 2386081 tttaagtccc cgagcaccaa gccaaccaac gtacaggcca ctagcggccg gtgtgtctgc 2386141 ccttcatcca atacacttgc gattccggtg attgctgcaa tgattaacaa caaaataatt 2386201 tgtaatgaag acatattctc atccccttga ttattttgtt acgttccgta aaatctgtac 2386261 aaaatcctca ctggcatctg aaggcagctg cctcaattcc agtttcacgc ccttgtcact 2386321 taatgtttca aatgccttta tatcttgttc tgtgacactg actgattttg tgatttgcct 2386381 gcgatgattt tcaaaacgca ttcccccgac gtttacggtt ttgatcggta cacctgcttc 2386441 tataagagat acaatatcgg acggattttc aaacaagagc attgccgtta ccccttcgta 2386501 gcgcggacta tgaaatgctt ttgccatttt agaaaccgag acggcactcg cctttacatt 2386561 tgaaggcgca acagaaagga tcagcgtttt tctcatttcg tcctgagcaa tatcgtcgga 2386621 gacaacgatg attcggtcgg ctgcatggac ttttatccac cttgtcagga tttggccgtg 2386681 aataaagcgg tcatcaattc ttgctaacac aatgttcatc ataattcatc ctctcttgta 2386741 tcttgattgg ctgtttttac tttttctaaa tgttcactgc acacttgaaa gctttgctga 2386801 ctcattgctt ttaagttgtt cagcaaatct ttgagagcca gatgttctct caggcttaat 2386861 acctccagca gaatcggcag gtttacgccg gcagccatat ccattctttg atcctcagca 2386921 ataaaggaag ctgccgcgtt atatggcgtc cctccaaaaa tatcgactaa aaaaagcact 2386981 tcatgttctt ccgggatatc cttgagcgcc tgatgatatt tttcttgcag cgtttgtatt 2387041 ccttcccctt tgaaaaacgg cactgcaatc aggttatttt cttcaccgaa tatcatccct 2387101 gaagactctt ttaatgctat gggaaaatct ccatgaccgc tgataataac tgaaatcata 2387161 tctattgctc ctttcctgtt ttgtacatcc atatataatg caaggatcgt gccaacacag 2387221 ttgtgttaag cgttttcatt gttatttcag ccaatagcaa tttgttgttg aaacacttaa 2387281 aacgaaaaaa ataaacctgt attaaaatgg tgttccattt aatacaggtt catatgaaaa 2387341 aactgttttt aaaacagctg gccatgcact tcttcagcaa atatggcggc tataaataat 2387401 ttttcatcat cacttatgcg aagtccgagc ttttcttcat aaggggctaa tgttcgctct 2387461 gtcacgtaca ccatttcctt cagctgatca ttgatctctt cttcctctga gaaagcgatc 2387521 ggattctgct taattaccct ttcaaaggcg aaagccgtgt gcataatgac tttgatcaaa 2387581 accgcattat tgaaaatgac ccccagctca tcctgaacgg tttgcagcca ctccaataac 2387641 atgtcgatca catggtgggg attcaagaag acaaggtatt ttttcaggct atcctcgcaa 2387701 agctccctga caataatatt tgcttcgttc aatccattgc tcaaggagat gcttcctttt 2387761 gtaatcgcct gttgaatcag cttctctccc tccccttcaa ttaacacttc taaagataca 2387821 tgcggagcat tgattttagg gtctttcgtt ccgactgtcg caaggatttc atactctttt 2387881 tcgatttctt ttatgctgtt ggccagctta atcgatgata cggtcaatat gtgaatgggg 2387941 gtatcggagg ccttgtttac gatcgtggtt agaatgtctt ccagcttttt ggccgttccg 2388001 ctacccgtcg tgcagatgga taccaatgcc ttctttttgc cggatgccgc tggctgacgc 2388061 tcccacaact cgataaaatc cttcgtgacc gattgataga tcgcatgcaa atttaaattc 2388121 aaatagttga cctttctgac agcatccagc accattgaag tcgtaacatt gctgatcgtt 2388181 ttaatagaaa tgcctgtctt ttcctccagc ctgctttcca gcattgcaag cgaccccata 2388241 tctaccagca ttaaaacacc ttcaccttca tcaacctgtt tcattttttc tgctacgcat 2388301 tcaagaatgt ccgaaggtga aacagtaagc ggcatgtcaa ctgctgcaat cggcgtactc 2388361 cctagcagtt ctgtcgcgac ttcaaccatt gaactcgccg tgctgtttcc atgagctgcc 2388421 acgataatac cgactctttt gttctccttt aacgatttga tggaatgaat taacatcgtt 2388481 aagtagatga cttctatttc aggaatagcc actttaaaat attcctgaat tttatcttta 2388541 aaaatcatcg ccacccgata ttctttcaca tgggtatcac gaatttcatc tgtctcctgt 2388601 gtattcaaaa catcaatttg ctttcctcgc tttaaaaatg cgtcaatatg catactcaag 2388661 aaataaataa acttacggtc aaatgtgcaa tccagctcat gttcagctat ttcttttaac 2388721 tgttttgtca tttgaatcac atcgtcttca acgaatgtca gcaggttgtc tttttgaaaa 2388781 gcttgatgat gaaaaaaact tctgacatgc aaatggacat cagtcaagat gtactggtta 2388841 atatcctttt tggataaacc ttctttcata agcgttttca ctttttcctc aatcaaatga 2388901 tataagttaa atgagaggtc ttcgtcaatt tttgttgttt catcttctac aatcggagag 2388961 ataatcgttg taatattgac atattcagaa atggctttgc ttctttgcat gtttttgctg 2389021 ctggacatcc attcttgctt gatttcatca ggcagatcgc gaacagtcag ttcaataact 2389081 tcatttctgt caaggttatg caaaaatccg tgtgcgcaaa ctaactgaac atttgatttc 2389141 agctgtccga cattcccaaa tttcgcagag tgaataagcg cattatagac atcgatatgc 2389201 acactcagat tcttcttaat tcgctctgct tctttcccta ataaaaacgt cgtcagatcc 2389261 actctttcat taagcgatcg ttcttcaagc gaaggaatat gaatggtcat tgggattctt 2389321 cgcaaaaacg ttttcaatag tgcagaactc ggattttctg tagtcgcaca aataaacaat 2389381 acgttcgatg ttcgtttatg ttcagattct ccaagcctgt tataagaacc gctgtcaata 2389441 aaataaaaca gcatttcttg tccctcggga gggagacggt ggatttcatc cataaaaaga 2389501 atgcccccat tggcctgttc gactaaaccc gccttatcct cggcagcacc tgtaaatgaa 2389561 ccttttttgt gtccgaataa ttgagaaagc aataattgag ggttgttgta gtagtctgca 2389621 cagttaaatg taataaatgg tgcgccggcc ttcaatatgt cagagtaaat ggcaaactgg 2389681 taaattcggt tcgcaaaaag ggatttaccg gaaccagtcg gccctaggag gagcatatgc 2389741 agaccgttcg gcggataaaa gacagctgct tttgcctggg agatcgcttt cttcaaactc 2389801 ccttttgccc ctatcataag ctctagggga ttcgtggaaa tgtgttgatg attttgcttt 2389861 gaatttccgg aaaacgcctg aaggtctttc acttccatca tctctgtatc ccatttcttg 2389921 ttgaataatt tttctgctat ctcgactggg atgtatctta caggaaatgt tttaattttg 2389981 atgacctttt tggaccggac gagattgttc aattcaaagc tgacattgga ccgctccatt 2390041 ttcagctgct cggcaatctc ctttgctgaa ttcccttgta tttttaaaag atgatctaag 2390101 gttgaatcat gaaaattatg cttgagctga tggtatattt tatctattct tctcacgtct 2390161 atcatccttt gtccttatta gataagccat taacaagaat atttcgaaac tttatagtcc 2390221 gcgttgagat ttacacgttt aaaaaggtct ctatagcaga ttgacaaagc tggcttttat 2390281 gcgtatatgt ttacatgttg aatcatttgc acctcatatt agtatgatag atgctcagtt 2390341 ctggagggcc agtccccttc aaaagtaata atcagtaaac agtttatcat tctcggggaa 2390401 tgtaatgatg tcaaaataat caatgacaaa aaatgaatct tatagatcat gacaaattac 2390461 ccaaatataa ccccttaagt tcgttcacaa ctaaaaagac ggacactcta tgtgaccgcc 2390521 acagtattac aatttgcaaa acttcgtcat ttttgcaatc cacattggag gttaaggaat 2390581 ctgtaagctt aaaaacttta tctccgatcc tatcgatttg atccccctgc cggcctcaat 2390641 catagtgggt atgcaattat acaaatcgtt accgattaaa actagcctgt cagattgtcc 2390701 aaatgacttt cctgttttac tctgctattc aggtagaatc acgagtgaaa aatagagcca 2390761 caagacatgt aacagcactt aaaatagttt taaaatttaa aaataaaagt atctattctt 2390821 ttaaatgtta taatatccga taaaacttta ctcatctttt tattactgga ggaaaataaa 2390881 attgataggc aattctagca aagacaattt tggccagcaa cagaaattgt ctagaggcct 2390941 taaaaacagg catatacaat taatggcgat tggaggtgca atcggtacag gtttattttt 2391001 aggttcaggt aaatccatcc attttgcagg accatccatt ttatttgctt acttgatcac 2391061 cggcgtattt tgctttttca ttatgcgttc gctcggagaa ctgctcttat caaatgcggg 2391121 ataccactct tttgttgatt ttgtaaggga ctatttagga aacatggcag catttatcac 2391181 tgggtggacc tactggttct gttggatttc cctcgcgatg gctgatttaa cggcggtcgg 2391241 catttatacg caatattggc ttcccgatgt gcctcaatgg ctgccgggtc ttcttgcgct 2391301 tattatcctg ctgatcatga accttgccac cgttaaactt ttcggagaat tagaattttg 2391361 gtttgcattg atcaaagtca ttgccatact ggctctgatc gtaactggta ttctcctgat 2391421 tgcgaaaggt ttttccgcag cttccggccc tgccagcctc aacaaccttt ggagccacgg 2391481 cggcatgttc ccaaatggat ggcatgggtt tatcctatct ttccaaatgg tcgtcttcgc 2391541 tttcgtgggt attgaacttg ttggactgac agcaggtgaa acagaaaatc cccaaaaagt 2391601 gatccctaaa gccatcaatc aaattcctgt ccggatttta cttttttatg ttggcgcact 2391661 tttcgtgatt atgtgtatct atccttggaa tgtgttgaat ccaaacgaaa gcccatttgt 2391721 tcaggtcttc tctgcagtag gcatcgttgt ggctgccagt ttgatcaatt ttgttgtatt 2391781 aacatcagcc gcatcagctg caaatagcgc tttattcagc acaagccgaa tggtctattc 2391841 acttgcaaag gatcatcacg cacctggact attaaagaaa ttaacttctt ctaacgtgcc 2391901 aagcaatgcg ctgttctttt catccatcgc cattctgatt ggcgttagtc tgaattattt 2391961 aatgcccgag caagtcttca cgctgattac aagtgtttca acaatatgct tcatttttat 2392021 ttggggcatc acggtgattt gccatttgaa atatcgaaaa acaaggcagc atgaagcgaa 2392081 agcaaacaaa tttaaaatgc ctttttaccc attatccaac tatttaacac ttgcatttct 2392141 cgcgttcatt cttgtcatat tggcactggc gaatgataca cgtattgctt tgtttgtcac 2392201 cccggtctgg tttgttttat tgattatttt gtataaggtg caaacccgca gaggacataa 2392261 ggtgaaataa aaaaaagaca agggatactc actcccttgt ctttttatat gtgtcaaaca 2392321 ctaaattaaa ctttggtttc aaatttcatt cacttcattt aagtgttaac tcaaaccagt 2392381 tttgatgccg aaacctacta atattattcc ggtaattttt tgaaacactt tctggaactt 2392441 cgagtttttc atccattttt ttgcgtaatc aataatataa acaagaaaca ggaaccacaa 2392501 caccgctaat aaggttagga ttgaagctaa aatgatgagc tgctggttta tatttccgtt 2392561 caaattgata aattggggca tgattgtaac atacaccaaa acagttttag gattgagaat 2392621 gttactgagt gatccctgca taaaggaagt tttataataa cgtttcggag aacttgccat 2392681 attttttgct tgggattgca tgtcatctaa cgaaaacata cttttagcaa aaaaactttt 2392741 tacacctaaa taaattaagt atgccgctcc caaatatttg atcgttgtga aaagaatcac 2392801 tgactttgcg attaccactg ataatcctaa aatggcaatc accgtccaaa aggaaagtcc 2392861 tgtcgccaat ccgagaatgt tataacggcc ggctttcgga ccatacctaa gcgtattttt 2392921 catcacaagc atcgtatctg cccccggtat gataaccatc atggcagcga tcggtatgta 2392981 tgcgagtaag ctgtgcattg ttctctcccc ctttaaaaat cccctcaatc atatagtgac 2393041 tacaaaagta actacttata aaagtgtatc aatgcgtttg gaataaatca atatgatttg 2393101 ttaaaatagc gattactaag gcagcgattg ctctttatat tggaggatat atgaaagaaa 2393161 atatgttaga cattttaaaa aacctcaatt ttacagaata tgaatcgaaa gcgtatttag 2393221 cattattgca agaatcacct ttaacaggct atgccgttgc caaaaaatcc ggagtgcccc 2393281 gttctaaaat ttatgaagta ttggaaagtc ttgtcataag gggagatgtt tttgtcagtc 2393341 atggaaatac gcctcagtat gttccagtcc ccgcaaaaga actgattaaa aaccgccggc 2393401 tcaaagcgga agagcatttt gatcaggctg agaaatattt tgaaaagttc gagcagaccg 2393461 caaatgaccg ggaaaacatc tggaatatca ccggccgcag tgaaattctt gaaaaggtga 2393521 aggcttgtat cttatctgcc aaaaaaagaa tcctcttaga aatatggaaa gaggatttta 2393581 aggagataga agcagagctc aaacaggcgg cagaacaagg cgttattgtc accattattg 2393641 cgtacggaga catcgtatct gattttgcca atgtttacct tcatgatatg agcagtgaaa 2393701 ttacagaaga gtatgacgga cggtggcttg tctatagcgg agatgattca gaagtagtag 2393761 cgggcattgt ctcacttggc aacgacagcc gtgctgcatg gacgatgcat gtagggttag 2393821 tcatgcctat tactgaagtg atcattcatg atctgtacct catggaaatt ctgaaaaagc 2393881 atagagagct tttagaagag agcttcggga aaaatctcat ccagttgcgc cgtaaatttt 2393941 ctattcactc agatttcaaa aaacattatt tggaataatg tttgtcatct cttaccccaa 2394001 aaacaaggct tgtacaaaac aagccttgtt tttttatgca taaacccccc atgctgattt 2394061 acttctctct tttaaaaaat gtgattctgc gcaaactatt tttcagcctg ccgcgtctat 2394121 cctaggtaac agcctacgat atacgtatat tcaaaaagga gccctttatt gcaatgaaga 2394181 aaaaacaaac aacaaaagcg ttgcttgtca catgcataac tgaccataag caagatttct 2394241 acaggttggc tttcagttat gtgaaaaatc aagatgacgc attagatatt gttcaggaat 2394301 ctataaaaaa agcgctgagc tcagttgaaa cggtcaggaa ccctgagacg ataaaaagct 2394361 ggttttataa aattttagta cggacagcca ttgacttttt gcgcaaacaa aaaaagataa 2394421 gagtgatgga cgacgaaacg atagaatttt taagcaaagg aaaggaagac cattacaagg 2394481 atactgatct ccatgaagcg cttgacgaat tgccgtaccg ctataaaacc attattattt 2394541 tacgtttttt tgaagacctc aaattagaag aaattgcgga aattacagga gaaaacacga 2394601 ataccgtcaa aacgcgccta tacagagcat tgaagctgat gcgcattcag ttgacgaagg 2394661 aggatctttc ttaatggata agagattaca gcaattaaga gaagaatata aaaatgttca 2394721 gattcctaaa gaattggata tcattgttga aaaagccctt cagcaagaac caaaaaagaa 2394781 aagaatcgtt atgtggccga catcagcagc aatcgctgca gctattttat tcactgcgct 2394841 tgttaatatc aacccggacg ccgctcaggc tatgtcaaag atccctgtca tcggcaaaat 2394901 cgtcaaagcg atcaccttta ttgaaatcaa agaggaaaaa gaccaatcaa gcattgatgt 2394961 caaaacacct gctttgtccg ggctttctaa taaagagctt gaaaacagca ttaacgagaa 2395021 atacttgaaa gaaagccagc agctgtataa agagtttata cagtccacat ccaaaaacaa 2395081 aaaagggcat ctcagcatct acagtgatta cgagacggtc acagacacgc cagatttact 2395141 ctctatccgg cgcaatattg aaacaacaca agcatcttcc tacacacaaa gccgttatat 2395201 tacaattgac aaaaagaatg atattttact tacattaaaa agcttattca aagatgagcg 2395261 ctatatcaaa gtcatcagtc aaaacatcaa agaacaaatg aaacagcaaa tgaaggaaga 2395321 tccaaataaa atatattggc tcactgacga agatgcagaa ccgttcaaaa cgattcttcc 2395381 tgatcagacg ttttacatta ctgaagacca taaacttgtg atctcatttg acgaatatga 2395441 agtcgccccc ggctatatgg gcgttacaga gtttacaatt ccaaccggcg tcatttcaaa 2395501 cttgctcgtg ggagaacgtt atattcgata aaataaaaac atccatctaa gattatggat 2395561 gttttctctc ttctctattc gaggtcgtaa ccccgctatc aaaaacaacg agaatatttg 2395621 catactattg gaggaatacc catgtatcac aagacacagc atcatcgata cattcctgga 2395681 cttgatggcc ttcgggcttt cgccgtcctg tcagttatca cttatcacct aaatttcaat 2395741 tgggctaacg gtggttttat cggggttgat atcttttttg ttttatccgg atatttgatt 2395801 acatctattc tattaccggc atatggaaat gatatcaatc ttgattttcg ggatttttgg 2395861 gtgcgccgca ttcggcggct tctcccggca gcgtacctta tgatcttttc cactgttgtg 2395921 tgggtcgtat tgtttgatcg agaactattg cacactgtac gtggagatgc gatctcttct 2395981 ctcttttata tgagcaattg gtggtttatt tttcacaagc tatcatattt tgatagtttc 2396041 ggttccccat cacctctaaa aaacctttgg tcgctggcga ttgaagaaca attttatatc 2396101 atatggccga tgtttttagt tgttggaatg tacataatga aaagccgcgc cagattggct 2396161 gcggtgatat cattgcttgt gctttgttca gccgtgatga tgagcgtact gtatgaacct 2396221 ggcggagatc cgagccgcgt ttactatggc acagacactc gttcgtttga acttctcatc 2396281 ggatgtgcct tggctttggt atggccgatg aaaaggctgt cttccaacag gctgccaagc 2396341 aaactgaagc acactttgca cgccactgaa tttttggcat tttgtatttt agtgttgtgt 2396401 gtctatttca cagatgaata cgagcctttt ctttacagag gcggaatgct attcattagc 2396461 gtgactgccg caatccttat tgcatgtgtt tgccatccga gcagcttttt aggcaatctg 2396521 ctttcatgga ggccgcttcg gtggcttgga acgaggtctt acggaattta tctttggcac 2396581 taccctgtta ttgtgttaag cacgccagtt caagaaatcg gaaaccctgt tttttggcat 2396641 atcgtgctaa aggtcattgt gacatgtata cttgccgagc tctcctacca ttttattgag 2396701 aagccgatac ggacacaggg atttaggtca ttttcccgcc gtgtttttat acatagaatc 2396761 aaggaatgga aaacgacatc tgtcatcagc aaaatgtcaa ttggtttcat tattttcgct 2396821 atacttattt ttgcaggcgg gctgtcaggg ctagccggcg agcaaaagca ccctaccaaa 2396881 tggacctata gctcacaaga aacaaatgct gacaccagcc aggcttctgg ggataaaaag 2396941 aacgctgcag cagataaaaa acacaatcct gaacaaaaga caacagattc caatcagggt 2397001 caaaaggaaa acaaagatag tgggcaagag actcataaaa agaaagacac gcaatcccaa 2397061 cagttgaaaa aaccagcaga cactgcgaaa gaagttttag ctataggaga ttccgtcatg 2397121 cttgatattt cttcacacct gcgtcagtca ttttcaaatg tgacgattga tggaaaggta 2397181 gggagacaaa tgtctcaagc tttggaactc gcaagggaat acaagtcttt taatcagccg 2397241 aacaaggctg tcatcattga gcttggaacc aatggctatt ttacaaacag ccaaatcgaa 2397301 caactgcttc aatctttctc aaaagctcat atttatcttg tcaatacacg ggttccccgc 2397361 caatgggaaa gcaaggtaaa tgaatctttg cagcaacagg cccacgcaca tcaaaatgtt 2397421 acgttagttg actggcatac agaagctctt cagcatccgg aatattttac ccctgatggt 2397481 gttcacttgg ttcctaaagg ggcaaaaact ttgactgctc ttattgttca ggcgatgaaa 2397541 tcgtaaaaaa gagatcctat acagatcact tttttacttt agtttctgat cgttgattat 2397601 gtcttctttc agcaaggcag cccttatgtt tacatgccgt ttacgtaagg gtaagccaaa 2397661 attgaatgga gggatgataa tgaaaggaaa tgaagaacat gacatccaaa aagagttgaa 2397721 acgatatgag ctttttttca aaaaacgata taaggttctt tatacagtaa acgattttat 2397781 catcggtgct atgtttctcg ttggaagttt tttctttttt tatgaccggt taatgtcggc 2397841 agggatatgg ctgtttgcga tcggaagttt gctgctgtta atcaggccga ccattcggct 2397901 gattcatgac tttcattacc gtaagcatgt ggaacagcaa ttcaagcatc aatcttcaac 2397961 agatgactga tcttaaggaa taagaaagaa caaaatgcca aaagcctgag tcgaaaatca 2398021 aaaacaagac tttcagacta tttattttta aaaacaaggt aaaaagaact aaacttttgc 2398081 ctctgcatgc cgatatgaat aataaggccg gcgcgatact ccctataaca tccttttcag 2398141 tagatttcat tatcgtgccg gttttctcat atgcaaagca atcccgccaa tcagattggc 2398201 gggattttat attttacatt cctgtccaaa cgtctttcac ataacgtctt tgatcttgca 2398261 gcttttgcag ccatacagct gattcttcct gacttgctgc tttttcagct tcatatgcca 2398321 atcgcaaagt tctctctaca tcaggagcca tttgcgatcc atcaccgcat acgtaaatat 2398381 gagccccttt ttcaatgagt gtcatcaatt tctgcgtatc ttgcttgagc aagtgctgga 2398441 catatccttt tggttcgttt tcgacgcgcg agtagcatcg gcggattgtg accaaaccgt 2398501 cctgttccgc ttgatccagc tcttctctgt aaaggtcgtc atggtccggg cggcggcagc 2398561 cgaagtataa aagtgcttca ccaagggtgc ttccttcctt cttcaaaacc gatcttgcct 2398621 gaataaagcc tctgaatggc gcaattcctg tgcccggccc gaccataatc ataggcgttt 2398681 caggatcatt cggcatctga aatccggact gcggcgtacg aatgaagcaa gctgctgcat 2398741 cacctgtatt caattctgct aaataattag aggcgacacc ccggtattca cctcggccgc 2398801 tccatgctga ggctttcaca actcctaccg tcatgctcac gatatttgca tgaactttcg 2398861 gtgagcttga aatggaatag tatctcggtt ttagtgatgg caaaagtgct aaaaaccgtt 2398921 caaacggcat ttcgcaagca ggataatcct ctaaaaaatc aagcatggta agacgttttg 2398981 caagtacctg ctctttgtaa atgccatcat ctgaaacgag ctgttccagc tctttttgat 2399041 gcggcggaca aactgtataa gaggccagct cccgaagctg aagccttgat gccggttcct 2399101 gcagctctac ataggacgac aataaatcca ctactttgat tggccgatcc atcggcagat 2399161 gagccatatg agcgcttccg cttactttta tcacatgatt ggactgcaaa ccgaatcggc 2399221 tgagaacccg ctgaacaagc tccctgctgt tctttggcag gattccgata tgatcgcctt 2399281 ctttatatgt tttaccagcc ggaatttcca attcaatatg gcgggttgaa cgcgtgctgg 2399341 cagctgtctg gagttctcga ttctctaaca caatcccttc aaacgcgcca tatgctttag 2399401 caaccggcgt ttccgtcgct tcactgagaa aagtaatcga taatgaaggc ctgtcttctt 2399461 tctgggctat ttcgttaata tcaaatgcgt ccatcgtttc cttccagaag cggttttccc 2399521 aagactcgcg gtggctttca aaatcatcgg cggcgtcacc ttccccaatc gctgttaaac 2399581 gcgatgcccc ctttgctttc atcatgtcat caatcaggcg gggaatccgc tgatacgtgc 2399641 tggcccagct ccggtttccg cagccgaata ccgcatagga aacacctttc aattggcctt 2399701 cctcaagctc tttcagccac tctacaaatc cggcagcatt atcaggcggc gccccattat 2399761 aagaagccgt tacaatgacg actgcccctt cttcagggag cttgccgata taatcatcaa 2399821 gcggagccgt ttcagctgta aagcccatct ggcggccttg agcagccagt tcaccggcta 2399881 ttccctcagc tgtcccaaga tttgaaccaa aaagaacaag taaaggtgtg ccgtgtttag 2399941 gtttggtttc ttttggcttt gtttctgctt tgatgtctgc ctgttctttt ctctgtacat 2400001 tgattgccgc tgtttttcgc ggtttcacag taattttaaa atcatccggc ttgatcgtta 2400061 atgcttcttt gatttttagt tcgtagccag tatggtttat caattcaaaa tgctttaata 2400121 caagaccgag aaccattgtc gcttcttgaa gagcaaactg catgccaata caagcgcgct 2400181 gtccgtttcc aaacggctta tacgcatggt gagggatact tgaaggatcc tcaaaccgtt 2400241 ccggacggaa atcttccgca tccggtcccc aagcgttttg atcccggtgc agttttggaa 2400301 ttaaaacagt gactggctgc cctttgctga tcggatattc cccgcctaga acagtatcct 2400361 ccttcgcata tagagaaaaa gccggagctg ttggatacag tctgagggtt tcatttaaaa 2400421 ccatccgaat gtatttgagc tgctggattt gtttatattc aggcgtgtca tccgttaaca 2400481 cgcgatccgc ttcctcctga gcttttttca gtttttccgg atgtgtaagc agacaataaa 2400541 tcgcaaagga tagcaacccg cttgttgtct catgtccagc aattaaaaat gtgatgattt 2400601 ggtatcgaat gttttcgtca tccagcgttt cacccgttac tggatctttg gcataaagca 2400661 tgagagacaa gagatcctta atgttttcat ccggattcgc ctttcgctcc gctatcattc 2400721 tatcaaccag ggagttcatg acttctatat ccttttggaa ctgcagcttc gttttcacca 2400781 tcattttatc ttgcaggccc agtcttttcg attgattcat cgcctctttt aaggcacgga 2400841 gcatactggt gataaacgga tgctgtgaat cacggtaaaa gctgttgaat cgatagttaa 2400901 acccgcataa cccaatcgta tcaagcgtca gacgtgtcat atcgtccgct acatcaattt 2400961 cttcattagg gtttaaccgg ctccactttt gaatcagctg ggttgcgata tccagcatca 2401021 tagaatgata gcctttcatc gctttttgac taaaactcgg cagcaaaatg cggtgggctt 2401081 tttgccagtt cggttcgtgc gtccagcttg taaataagcc atctcccccg aactcacgca 2401141 ccttttgcaa gcctttgcca aggttcttgt caaagcgttt ttcatcacac acttcagcca 2401201 caagattgtg gccggacaca aaaacactgg atactcccgg aaaatcaaaa cggaaaatcg 2401261 gtcccaattc atcagctatc cgccataagg attgagaaag ctgttctttt tccagatgcg 2401321 gaagattttt taaaggtccg tatgttttgg gctgaggtat tgcgcttgcc tgtttcatta 2401381 acatctccct ttcctatttt tgtgatgaat gaagcttaat ggcgtcccag cagcattgtt 2401441 ccaattcagt aattaaatca gtgtccatct ctatatcacc tgtttgaacg agctgatata 2401501 tcttgagaaa cgcccctaat acaatcgcaa ttaacacatt agagggcagg ctgcgaatca 2401561 cgccttccgc ttttccctta ttaaaatagt catcaagcat ttgagtcaga ttttctatca 2401621 tttttttgct tgtatgattt aagtaatgag cgtctttttt ggtttcaaga aaaaaaagcg 2401681 catagtcgct ctctttcgta aactgaacga gacagcaaaa tacgtggtga aagccttctc 2401741 tgacaggcaa ttctgaaacg tcttgcttca gtttttccgt aaatcgctgg atgctttctt 2401801 gaaacagtac gttaacgagt gtttctttgc tgtcaaaata acgatagatc gttcctgtcc 2401861 ctacatgagc acgttcagct atcataggaa tagtggtagc gtcaaaaccc ctttccgtaa 2401921 aaagtgagac tgacgctttc ataatcatgt cgtatttact gctggatgcg gatatcatgt 2401981 aatctgacaa cctccgattc gtttacggaa tgaatattca ttccttttgt tcacaaagaa 2402041 tgtctgccct gtctgatatc acctctttgt tctttcttct gttataagtt tatatgaaaa 2402101 aaactttttt taatataaag tatatgcaaa aaataaaaaa ttaagaaaat atacccaaat 2402161 cctaatacga ggatcttgga tatatttccc gagaaatttt ttatttaaca gccacaatac 2402221 atagacagga agcacgcctg ataacagaaa gatccctgaa atgctggtct ttcagcagtt 2402281 gaatatacgt tttctctttt tcaccggtat ttgtgtcaat actgatataa aaccggccgt 2402341 caatttgaag caccctgtaa atttctctta atgcaagcct aatatcggtg cagctttgaa 2402401 ccgtatgtaa agaaaagact ttattaaagg tacggtcatc aaagggaatg tcctctggat 2402461 agccatgaaa aacctccccg ttccccatgt tctttcgatt cgcacgtgat atctgtctta 2402521 cctttcgttt tgaaggatca atgcttttta ggctaccctt ttttagtttc ttggttatgc 2402581 ttttaaagac agtgccgttt ccaattccaa tttctaaaat tctgtcattt tcttgtatat 2402641 ctatagagtc aatcatcata tgctcaattg ttttggttag cttatatttc cgagaaaata 2402701 atttccaaaa atccgatcgt ttatagagtc tattttctag cattttaaac acctgctttt 2402761 ggtttcctat gtttatttat tatcttaaaa aaataaacat catcttcatt tctaaaagtg 2402821 aaggaaggta ccaactagac ggcaatgtat tgaaaaatgt ttcaatagaa ctaaactttt 2402881 tcattttttt ccgaaaaaaa agcagaaaac ataatgtttt ctgccctctt tctaatgcca 2402941 atgataaggg aatacataca gcctttgctg ctgcattgcc atcagcctct gctgtcggaa 2403001 tggatttcca taaccatgtt tgaaggaatg cggcatggac gcataaccat ggccaatcga 2403061 cggcagtctt ttttgataat cgttcatcat gccatcacct gcctcacaat aacgttgatt 2403121 tactatatgc aggcgcgcat tttcttgaca gctatttcgc taaacttggt ccttctccat 2403181 tgtataatgc atcaatagtt ccattctaag catatgccat tcccccttca gtttttttcg 2403241 ttgcttttag cgccagtttg ttaaataaag atgctttaac tgagactctt tcatttcatc 2403301 ataaatttgt tcaatctgct gttctcgttc gaattcttcc aggcttttaa accgtttttt 2403361 aatcgttaac gttaaaaaga ataggttaat cgtcatatcg ctcaccccct ttcaaagtcc 2403421 gcatcaagcg aaataacccg cggcacaacc cttctgccgc gggcaaataa aaaccgcaga 2403481 caaaagaaga caccaatgcc tctactgcct gcggggagtt gcgtatgtcc gactattccg 2403541 aatttaatgc gtgcgataag catcggttaa ggaaggacac gaactcttcc acaggctgaa 2403601 taaaccatga acttttacat gtgtatcacg tacaggttga cgtcgttgtc tcattgtcat 2403661 tttggttcag cctcctttgc ttttttctta ctttgtaagt atatccacca aattccattt 2403721 tgtaaacatc tttttctaaa aatggacgga aattgtgcaa atcatcgaat ggatttgccc 2403781 gttggtcatg acacctgctt catttctttt ctggagcggt ctttcttatg atatgcaata 2403841 aaataaatga gaccgacaaa tacagctccg ccgatgacat taccgataaa agccggaatg 2403901 atgtttccga tgaactgccc ccacgtgaat gagcctgcaa aaatggcagc aggaatcaca 2403961 aacatgttgg cgacaacgtg ctgaaatccg atagccacaa aagccatgat tgggaaccag 2404021 atgccaagga tttttcctgc tgcgtcttgg gcgccgaaag aaagccacac tgcaagacat 2404081 acaagccagt tacagccgat ggcggaaatg agaaccttgc caaagctcat atcaagcttt 2404141 ccttgggcaa cggcaatcgt tttttctaaa taaggacctg tttcagtcaa tccaaccaaa 2404201 tgcccgaaaa agtaagcaac aaacaatgcg ccgattaagt tcataattgt gacgattccc 2404261 cagttaatcg ctaactcttt tactgatatt tttctcgaaa ataacgccat cgcaactgac 2404321 atcatattgc ctgtgatcag ttcagcgcca gcgagaacga caaggatcag gccgactgga 2404381 aatactgctg caccaatcaa actggacagg ctcccccatt ctttcggaag atcgccaatt 2404441 accctgatat caagcaaata cccaagcgcg ataaatgcac cgcctaaaaa ccccagcaca 2404501 agcagtgacg gcagcgggag ctttattttt ttcatccctg cttcaattgc tgcttccgct 2404561 atttcatccg gttttcgaaa agccataata aaacgcctcc attacttctt cttttctcac 2404621 agttatgcaa gaaaggcaat aaaaaaggca gcactcaaat aacctgtgtc aaaccaggcg 2404681 tttgaatgct gcctaacttg tatgcatacc catacaacaa tatcaagcag tatataagat 2404741 attgaaagag aatatataca gttcgtgcat acattccatt gctttagcct tctataactg 2404801 tagcaacatc atatcaaatg tgacaaattt gtgtcaatga caaatatact agctttgcag 2404861 agcttctttt tgctcatcta tttttcggtc aaaaacaaat acagatacag cgatgttttc 2404921 ctcaatttta atatcagaaa acaaatggac tagcttagct cccataagtt cctccattcc 2404981 ttccggtgtt tgtttggaat aaaggtcttg aattaggctt gtccgggccg catgtaccat 2405041 ctctcttcct tcaggcgtgc gggcaataaa ctgctcgctt gcactcagat ttccgtatag 2405101 tgttgaaact gccatgtttt ctacaaatac agtatgaatt ctctcaggcc cttttccgaa 2405161 caattctttg cgaagttttc gaataatatc attgaattca tgaatttttt tagacatgct 2405221 gattacccct tccgatattg ccttataaag gcttttcccg gttcccctca ggacatttca 2405281 cttggttaaa attttcctgc catattgtat tataataaat atcacattat aataaaagca 2405341 gtgttgatgg atttgtaata ggatcttgtt atgagtctat cgttttataa aaatcaagga 2405401 ttggtctgtt agtaagactt gctagtgaac tattccgcca tgtgtgttta caccttctta 2405461 gaattaaggg caggtgtatc tatacatggc tttttttgac ttcttgaaag aaagatggag 2405521 gggaatatga atatgatgga cgttaagtcg atcagtgtcc gtgtagacgg aacagaaatt 2405581 caagcacgag caggggccac aattttagat attttaaatg aaaacggaat tgagtacccg 2405641 cagatttgcc acgtaccaga ggttgacccg attcaaactt gtgatacttg catagtagag 2405701 gcaaacggca agctggttcg ttcatgcgcg acggttgcag aaaacgggat gtctattgat 2405761 ctttcaggaa atcgagtgaa agaagcgcaa accgaagcga tggaccgcct tcttgaaaat 2405821 catttgctgt attgtacagt ttgcgataac aacaatggaa actgtacgct gcataataca 2405881 gcggaaatga tggggatcga gcatcaaaaa tacccataca cgccaaaaga agatccttct 2405941 tgcgcggttg atatgtctca tcctttttac cgctatgatc caaaccaatg tattgcctgc 2406001 ggccagtgtg ttgaggtctg tcaaaacctt caggtaaatg aaacactctc aatcgactgg 2406061 gaacgcgaac gccctcgcgt catttgggat gagggagttc cgatcaatga atcttcctgt 2406121 gtcagctgcg gtcagtgtgt aacagtatgt ccatgtaatg cactgatgga aaaatcaatg 2406181 ctcgggcagg ctggttttat gacaggcatt aaagaggacg tcatggaacc gatgattgat 2406241 ctcgtgaaaa atgttgaacc ggggtatggc agcatttttg ccatttctga agtcgaagcg 2406301 gcaatgcgtg aaacgagaac gaaaaaaacg aaaactgtat gtacgttctg cggtgtcgga 2406361 tgttcatttg aagtatggac aaaaggacgg gatattttaa agatccagcc tgtttctgat 2406421 gctccggtta acgcaatttc cacatgtgtc aaagggaaat tcggctggga ttttgtcaat 2406481 tcaaaagagc ggatcacaaa gcctttaatc cgtaaaaacg gagcctttgt ggaatcttct 2406541 tgggaagaag ccctcgatct tgtcgcaagc agattaggat caattaaaga gcagtacggt 2406601 aaaggctctg tagggtttat ttcttcttct aaaattacga atgaagaaaa ctacgtcatt 2406661 caaaaactag cgcgtcaggt atttgaaaca aacaacgtcg ataactgctc acgctactgc 2406721 cagtctcctg ctacagacgg attgttccgc actgtcggca tgggcggtga cgccggcacg 2406781 attaaagata ttgccaaagc aggcctggtc atcattgtcg gtgccaatcc ggcggaagga 2406841 cacccagtgc tcgcaacacg cgtcaaacgg gcacacaagc tccacggtca aaaactgatt 2406901 gttgctgacc tgcgtaaaaa tgagatggct gagcgatctg atctgttcat cagccctaaa 2406961 caaggcacag accaagtttg gctgatggct gttacgaaat atatgatcga ccaaggctgg 2407021 cacgatcagg cgtttattga tgagaacgtc aattactttg aagattataa agaaaccctt 2407081 aaaacgtata cgcttgatta tgcagaacgc atcacaggcc tttcaaaaga aaacatcatt 2407141 caaattgctg aaatgattcg tgatgctgac ggcacttgtg tcctttgggg aatgggtgtc 2407201 acacaaaata caggcggttc tgatacatca gcagccattt caaacctgct tctcgctacg 2407261 ggcaactatc gccgtccagg tgccggcgct tatcctctgc gcggacacaa taacgtgcaa 2407321 ggcgcatgtg atatgggaac attgcctggc tggctgccgg gatatcagca tattacagat 2407381 gacaaagcac gcgctaaatt tgaagaggca tatggtgtcg agattgatgg aaagcctggt 2407441 ttagataata ttcaaatgct tcatgccatt gaagaaggaa aaatgaaagc tatgtatctt 2407501 gtcggtgagg atatggcact ggtcgattca aacgcgaacc atgtgcatga tattttatca 2407561 agccttgatt tcttcgtggt acaggacatc ttcctgtcaa gaacagctca atatgctgat 2407621 gtcgtcttgc cggccactcc ttcacttgaa aaagacggaa catttaccaa cacagaacgc 2407681 cgtgtccagc gattgtatca ggcgcttccg acgcttggtg acgcaaaacc ggactggtgg 2407741 attattcaag aggtggcaaa ccgtttagga gcgaattgga attacagcca tccaagtgac 2407801 attttctctg aaatggcgag tctttctcct ctgtttgcca aagcaagcta tgaggtgctt 2407861 gaaggctgga acagcttcct atggggcagc ttcacaggtg aaagcacacc gcttctgtat 2407921 gaagacggat ttaatttccc tgacaaaaaa gcccgctttg ccctttctga ttggaccgag 2407981 ccagcggcat ttccggagga atatgacctt catatcaata acggccggat gctggagcat 2408041 ttccacgaag gaaacatgac aaataaatcg aaaggcatcc aagcgaaagt gccgaatgta 2408101 ttcgttgaga tctcacctga gcttgcacaa gagcgaggtg tttgtgacgg ttcgcttgta 2408161 cggctcgttt ctccgttcgg agcagtcaaa ttgaacgcgc tgatcacaga ccgggtacgg 2408221 aaaaatgaac tctatttgcc aatgaactcg acagacaagg agtcagcgat taacttcttg 2408281 acgggccctg cagctgataa acggacgaac acgcctgctt ataaacagac aaaggtccgc 2408341 atggaagtgc ttggcggctg tgaaacagcg ccgcttccaa aaacaaatcc gcgcaacaaa 2408401 aaacggcatc cgcaaaacgg agtcgaagca gaaagaaaat ggaaccgccc tggctatgta 2408461 catctgactg attaaacgat aggaggaaaa cgaatggcca ctccgattac gacgatcaaa 2408521 aaagaaacaa aaacagctga gcaaattaag cttgaaaaaa tagaagaact gaaagagctg 2408581 ctggcggaaa atgaggacgc cgtctctaaa acgatgacgt taatgaatga actcaatgat 2408641 cttggaattt ttgatgcggc aacaagcatg ctcagagcga aggaagacat tgccaagatt 2408701 gcgcttggcc aagtttcccg cgagcctgtc accaacctca tcaacacgat gatggccgcc 2408761 ggaggcgcat tgacaaaagc cgatcctgag tttacagcaa agcttttaga aagcgtaatg 2408821 gctgggactg aacaggcaca aagcttttta aaagaagaca agaaagtcgg gattctcgac 2408881 ctgttaaaag caatgaacga tcctgacatc aacagagccg tcgggttcgg ccttcagttt 2408941 ttaaaaggca tgggaaaaga acttcgagaa caataacaga aaaacagcca tctctgatga 2409001 tggctgtttt tttattcgtc ggcttcttcc agacgcttct tgtaaataag tgaacggtca 2409061 gcgcaaaaga aggcaccggc taaaaatacg caatccgcta aaaacatcgt cgatttctgg 2409121 cctaatgtta agccttgatc agggagaact gcgcctatat ataaaaaagt gctgactgca 2409181 agcaatgtaa aagcaaaatg cttgtagtct tcttttaaag atttcattct atttttgttc 2409241 aaaagaatca cctgccagat tcatagtata cgactattat aatataatcc ggcggcttac 2409301 agagaaagta attctatcca tttgttatat attttcaagc gcttggccga tatcttccaa 2409361 caagtcttcc gcatcttcaa ttcctacaga aattctgatc aagccgtccg taatgccgag 2409421 ctcaagccgg cgttctctcg gaatagaggc atgtgtcatt cttgcaggaa cagaaattaa 2409481 gctttcaacc gcccccaggc tttcagcaat ggtaaacagt ttcagatttc ctaaaaacgc 2409541 atcaacccgt tcttcactgc caatatcaaa ggagatcatg ccgccgaagc ccgctccttg 2409601 cgtttttgca agctcatgtc cgggatgatt tgaagaacca gggtaatata acgtttggac 2409661 agcagggtga ttctcaagaa agcttgcgat tttccgcgca ttttgatcga tcgcttccat 2409721 tctgagtccc aacgttttga ttcctctcat taacagccag gaatcttgag ggccgagcac 2409781 gccgcctgtg gagttttgca caaaatgcag ctcttctcca agctctttcg aagctgtcac 2409841 aactaaacct ccgacgacat cactgtgtcc gccaagatat tttgtcgcac tgtgcagtac 2409901 gatatcagcg cctaaagtaa gcggctgttg aaaataagga gtattaaagg tattgtctac 2409961 gataagcaga acacccgctt tttttgcgat atcagccatg agcgtcaggt cggtgatttt 2410021 gagcaacggg tttgtcggtg tttcaatata aattgctttt gtattagggc gaatcgcttt 2410081 ttcaacttct tccctgctgc tcgtatcaac aaatgttgat tcaatgccaa gacggttaag 2410141 cacctttgtc atcacgcgat atgttccgcc gtacacatca tcagtcaaca cgacatgatc 2410201 tccgctgtta aacagcatca taaccgctgt aatggcagcc attcctgagc tgaacgcata 2410261 gcctgcttcc ccgctttcca gttctgtcac aagtgcttcg agagcggttc gagtcggatt 2410321 ggccgttctt gaatactcgt agcctgtatg ctgccctgct ttcggctgct tgtacgtgct 2410381 tacttgataa atcggcacgg aaactgcgcc tgttttctca tcacctgtga ttccgccatg 2410441 tatcatcaat gtttttttct tcatatcaga tgcctccttc gtatatttgt ttgctgatat 2410501 atcgatcgct gctgtcagga aatactgtga caatgttagt tccagcggat gcttttttcg 2410561 cttcctccaa tgccgcataa agcgctgcac ctgaagagct tccgatcagc aggccttctt 2410621 tttctgccgc ttctttcaca agtctaaacg cattctcatc tgttacggtg tagatctcgt 2410681 caaaatggct cttatccata taatcgggga taaactccat gccgatgccc tctgttttat 2410741 gagcgtgggg ctctcctccg tttaaaatcg agcccaccgg ttcaacaatc accgttttga 2410801 ctgctggatt tttttctttt aagaaggaag ctgtccctgc gaatgtgcct cctgatcctg 2410861 cccctgcgac aaatgtatga atattcccgt caagcgcttc ccacatttca ggtccaagcg 2410921 tcttatagta agtcgatgga tttactcggt ttttaaattg caaaacgcaa taagaatttt 2410981 caatttcagt ctccagctga atggcttttt gaatggctcc ctgcattccg tcttgacgcg 2411041 gtgtatgaat gattgatgcg ccaagcgctt gcataatttg ctgtttctct ctgctgaaat 2411101 gttcagggac acagaaaatc gctttcagcc catattttct ggcacttaac gcaaggccga 2411161 tccctgtatt gcctgccgta gcttctataa tcactccgcc gggtttcact ttgcctgaat 2411221 cgagcgcgtc acgaatcagc atatctccca gtctgtcttt gatgcttccc cctggattca 2411281 tcatttcaag cttggcatac accgcgactc cttctggaac atcaaagttc ttcaagcgga 2411341 gaagcggtgt attcccaatc agctcggtaa tgtccgtaat cactgtcata tatgtcctcc 2411401 tccttaatag aggttgtttt tagagaaaaa cggaggagaa cgttctcccc gttttaatga 2411461 attcgtttga tcacctttaa cacaagctct gttgaatgaa cagccgcctg ctctaaaaat 2411521 tggtcaaatg aaacatgtga ttctttgcct gcgatatctg ataacgctct gatgacgaca 2411581 aacggcgttt taaattgatg gcatacttga gccactgccg cagcctccat ttcaaccgcg 2411641 tacagatcag aaaatctcgc acgcacctct tcaacccgct tcggatcgtt catgaaagaa 2411701 tcgcctgttg caatcgttcc ttttgcaacc tgaatgccgt cgagttcaga taccgcttct 2411761 tcagtgatgc tgatcagctt ttcatccgcc gcataagcag ccggaagacc cggcacttgg 2411821 ccgtattcat agtcaaaagc cgttacgtct acatcatggt ggcgaacgtc agtggaaatg 2411881 acgacatccc ctacattcaa tgtatgatga aatccgccgg ctgagcctgt gttaatgaca 2411941 taatcaggct tgtaacggtc aagcagaagc gtcgtgctga tagcagcatt tacttttcca 2412001 attcctgatt ttaaaagaat cacttcagtt ccttcatatt cgcctgttgt aaattcacag 2412061 tgtgcgatcg tttctgtttt tgcattttca agtttgtttc ttaagatggt aacttcctct 2412121 tccattgctc cgatgactgc tagtctcatc tattcacatt cccttcactt taccgtttga 2412181 tcgcctccat tatccacacg aagtcgtttt gctgagtgaa tcggactgca aaaccttcag 2412241 ctgtaaacat ttctttcaac gcatccaatg taggataatg ctctgtctct aaatcatttg 2412301 caagctgata aaagccttga gaacgggctt tatcgatagc ctgttgatac gcttgcgcat 2412361 tttcaaagac ggtatcggca aacactattt tatcatgcaa gtgaaggtat ttgccatatt 2412421 gctttatggc agcccgcttt tcttcgtcag tcaaatgatg aaaagcatat gaactgacaa 2412481 tcgtatcagc ctgaaatggc ggctcaggga atgtcaggaa gtctccatca acgatttccg 2412541 tcctgcctga gagcttgtca gaagccagtt tacgcattgc tggagaaggt tcgattccaa 2412601 atacagtttt gcctgcatcg agcagcttag ctgtcaaatt cccggtcccc gggccaaatt 2412661 ctaacacatg cgttccagat tttctgacga tggcatcaag gatatgatcg tagcctctga 2412721 acgcttcttt atactgaata tctaaacctt gtactgtttg atcataagtt gctgcccaat 2412781 cttcaaagag agggataaat tcacggccca tatttgtcac actccatatt taataattcc 2412841 tataagtata ctatggatta atgatggaac agttcctata ataccacata ttctgaaaag 2412901 caggtactaa aacactttgt gtattttatg ccatctcata ttgcgcattg accgcaaaaa 2412961 agcttatact tcatatgact tgtgaaagct ggagggtcaa gacatgaatt ttcaattaga 2413021 tctgattaaa gacaaagtgg aattttttga agcggcttca ttgcaggagc ttgaaaagaa 2413081 aatcaataca caaattgaaa acaataaagc catcatgctc cgggtgaaat ctgtttcaca 2413141 ccaaactctt gtggcagaag gaagaatatt gtacagcgcg gtggttcatt tctcagctga 2413201 agcctaaaac aaaagcagcc ggttttaacc cggctgcttt tgtttatttt agcttttcta 2413261 cttttgtcgg cttccagcct ttttcatcga cccatgtaat cgtgacttga tatttattcc 2413321 cagtcgcctt gtccaaaatc ttgcctttgg catcctgagg gctgccgtta tttccaagcc 2413381 agagcaccgt catgttatct gttgagacac cagttgcgta cgaaatggct ttcagcatct 2413441 cagcccagtc ttgtgagctt gaatcataag tagcggcatg ctcgccagtc tgctcagttc 2413501 cgactgcttt ccagtcagga ttttcatacg ttttttccac atcgctcgat gagccgcctt 2413561 ctgttacttt tgcatcttta agcccgtcac cggctgaatc tgagcttgaa tctgaatcag 2413621 agtcatcttt tttagaagaa gaatcatctt ttttggaatc agagtcagaa gacttctcag 2413681 aatccttttc gctgtcagat gtatctttct tgctgtcttt tatatcctca tccgatttct 2413741 tttccgtctt tcctgaagcc ggagattcct gtttttgcgc cgtttcagaa tccttgctga 2413801 catctttgct agaaggactg ttaatgaaga gattcgctgc tactacgaca attagtatgg 2413861 atacgattgc gattaaaatg ttaagcacta aattggcttt tctgcgttta tcacgatttt 2413921 cataacgaga ttgattattg ctcaataatt ctgcactcct ttatccctct tggctcagca 2413981 tatattttaa catgtgctga gaagttgttc tatttctgat tgatttcaat ttcgtgtact 2414041 tttttaacaa tatcataaaa caccgaattt gtcagagcct tatctcccgg tgtatccatg 2414101 tgtaaaacaa ctagagcgta tttcggctta tccgcgggaa aatatccggc aaaccatttt 2414161 tcgtagagcg tttccttctc ttttgaaagc ttgcctgtct gggctgtgcc cgacttccct 2414221 gctacagtat acggaagatc ttgaaacctt ctgcccgttc cggaaggaga ttctactacc 2414281 cgccgcagta ttttttgaag ctgctgtgac gtatatttgt ctatcgtttc ccctttgagc 2414341 ttctgatctt taaacgtaac gagcgttgtg ccgttcttat actcaatttg ttcggcaatt 2414401 ttcacctgcc gtttttctcc gccgcgggcg attgtcgcca tcatattggc tacctccagc 2414461 ggcgttacct ttacattttt ctgcccgatt gctgtttgcg caatggcttt tttgactgat 2414521 ttgtcttttt catcccccca aatcacgccg cttttttcgt tatacagctg gcggaaatcg 2414581 gtttcgtggt acagttttcc ctcccagcct gcccgatcag tgagagccag cttctcggac 2414641 atatcttcaa taaccgagct gtcttttttc attaattgtt ctgcaagact cgtaaatgtg 2414701 taattacagc tttgggcaaa actttcatca aaagacaagg tgcctttgtc gtcccccggt 2414761 tccccgtaca ggtttaaatt gcaattaaag gtttgactag gcttcaccat attattttcg 2414821 attgcagctg cggcaatgac tgttttaaaa actgatccgg gatagattgg cgtcagcata 2414881 taattttgaa gtgtgttttg ccgggacacg tctgcatctg gtttgcttac aattcccaga 2414941 acactgctat tttcgatgtc cagcagcaca gctcctccct ttttcagccc ctgttcatcc 2415001 aatacctcct ccatcgcttt ttgaatgctt tgatcgatcg ttgttttgat ctggagcgga 2415061 taaaatgtat tggcttcagc tgtatatttg acgtccatgc caaacaaagg gtttcctttt 2415121 ccgtccacat gatataaaag ctttgtgtct tgttccggaa gcaaaaactc gtcaaatgtc 2415181 cgttctaaac cggttgttcc gatttctgtt gtaatcggaa ggctctcctt gtcaggatat 2415241 ttcttgcgaa gcagcgccgg atcttggttc gtgctcccta tcgtatgtga agcaaggctg 2415301 ggcttgtctt cattctccat atatacgccg taaatgccgg gatatttcaa agaattgatt 2415361 tttgtgatag attgttttga aagtgttttg attttctttt gctgcaaaat gaccggtttt 2415421 tttgcctgac ctagtgtctg gcgcaaatca tcttcagaca tgccgaggat gtccgcaact 2415481 tttttgatcg gccaatcctg cgtcagcaga aaagggaaca aaacaaccgc aggctcgctt 2415541 tgtcctgtca gcgcccgccc gtttcgatct aaaaaagagc ctcttccatc tgaaatgagc 2415601 acttcctccg tccgctgttt cacactttct tgaatcaaat taattttctt tttagaaaat 2415661 gattctgtga aaaacagctg gatttctgca agtctcagca gaagcagaaa aaatacaatc 2415721 aaaaaagcga tgactgccag cttcattcgt ttcgatatct tcataaaaaa acacctcacc 2415781 cacattgtgg acgaggtgtt tcgctgctaa acagatatta tgaaattttc acaattttca 2415841 cgagcatttc tccgcccggt gtttgtactg tgacttcttc atctactttt ttgcccaaga 2415901 ggctttttgc gatcggtgaa tcgtttgaga ttttcccttc aaacgggtca gcttccgcgc 2415961 ttccgacgat cgtatatgat tcttcatcac cgtcaggcag ttcgacgaaa gtgacggttt 2416021 tacccaaacc gacaacgtta gagccgccgt catcttcaat gattttcgca ttgcgaatca 2416081 tattttcaag agtcgtcacg cggccctcta caaatgcctg ctcttctttc gctgaatcgt 2416141 attcagagtt ctcggaaagg tctccgaagc ttctcgcaat tttgattcgc tctactactt 2416201 cttttcgttt aaccgttttc aaatattcta attcttgttc aagtttttgt tttccttctg 2416261 cagtcatagg aaaaactttc tcttgtgcca tgtcccttca ctccttctgg ttgtccctca 2416321 acatcttcga ttatgtatga gagcataaac taaaaaatac aagaatgaga acacagggca 2416381 gtcctcgttc ttctctccca tataggtact gtttatctta aactgaatcg tgtcgttctg 2416441 caaatatttc gcgtttataa acagggaaag aagggaattc gcacattccc ttcctgccta 2416501 tacataatat ggtcagagtt atttatgtct atgctatggt attacaaaat cgcgttttgt 2416561 tcaagaatgg tttgaatttt tgtgaccatc agatcaattg cgacgtgatt ctgaccgcct 2416621 tccgggataa taatatcagc gtatcgtttc gtcggctcga cgaattggtt atgcatcgga 2416681 cggaccactg acacatattg ttcaatgaca gaatcaatag agcgtccgcg ctcattaata 2416741 tctctcataa tccgtctgat gatacgcaag tcagcgtccg tatcaacata aagcttgata 2416801 tccatcagat cacgaagcct tttgtcttca agaacaagaa tgccttcaag gataataaca 2416861 tcctttggct ctacgtgaac cgtttcttct gaacgtgtgt gaagcttata gtcataaatc 2416921 ggcttttcaa tcgggcggta attcaataga tcttgaatat gctcgattaa atagtcatta 2416981 tcaaacgcaa gcggatgatc atagtttgtg ttcagccttt cttcaaacgg aagatggctt 2417041 tggtctttat aataaaggtc ctgctggatc attaaaattg agtgtccttt aaactgttca 2417101 taaatggacc gtgtgacact cgtttttcct gaaccggaac ctcctgcgat tccaatgact 2417161 actggattct tacccatggg ctgttacttc ccctttctca tcatgttgct cggataaatc 2417221 tttttgtcta gtttgaattt gacaatttgc aggggatggc gggcagcatc tagctcattt 2417281 ccgtcttcgt cccaaatggt ttcaatcgta tgtgtaaagt tttcgatttc tggaccgaaa 2417341 aattccactt cgtcgccttt tttgaagaaa ttgcgctgct gaagcgtgac catttgtgta 2417401 tcttcatcat aattcagcac taagccgaca aaatcatatg tcgttttctt ggcgtgttcg 2417461 ccgaacattt gctcttcata gcctggcgtt ccttcaaaga aagctgtcgc agtgtccctg 2417521 ttggcgcact tatcaagctc ttcaagccat tctttttgaa tcacaaagtt ttctggatca 2417581 gcgcaataag catcgattac tttgcggtat acgctgacaa cagttgctac atagtgaatg 2417641 gatttcatgc ggccttcaat ctttaagctg tcgatcccca tttcaatcat ttttggaatg 2417701 gattcaatca gcttcaaatc tttcgggctc atcgcaaatg gtgcatcttc ttcaccatac 2417761 aaagcaacgg cgttggcacc gtctgtttgg tagagatcat aatcccagcg gcatgactgg 2417821 cagcagcctc cgcggttgga atcccgcgct gtcatgtgat tgctcagcac gcagcggccg 2417881 gaatatgcaa tacacattgc gccatgaatg aaggattcga tttcgatatc taccttttct 2417941 ttcatttctc tgatttcaag agcgctagtt tcacgtgcca gcacgacgcg gtcgagacct 2418001 tcttccttcc agaactggac agccttccag tttgaaagag actgctgtgt gctcaagtga 2418061 acctcaacat tcggcgccac tctgcggcat gtttcaataa taagcggatc tgccacaata 2418121 ataccggcaa cgttggcgtc tccaagcgct tttaaatagt cttcaagccc gtccatgttt 2418181 tcattatgag cgaaaatatt cgttgttacg tagatcttcg cgccatattt ctttgcgaat 2418241 tcaacgcctt ctgcaatttc ttcgatcgta aagttatcgg cattcgagcg aagcccgtat 2418301 tcctgtcccc cgataaagac cgcgtccgct ccgtaatgaa cagcgatttt cagcttttca 2418361 agattacccg caggtgcgag aagctccggc tttttcgtaa tcacacgctt tccattaacg 2418421 attgtggata ttttatcatt tacggcagtc atagcttaac ctccttttga ttaataaacc 2418481 gtttccttga agaagaatcc ggtatcaatt tttctgttta ctggctggat gctttcaatg 2418541 cgttcgatcc agtcttcttt tttcgcttcg tattcgtcac ggttttccac gcacaaatca 2418601 attgcttctc tgtacatttt ggtgacttct attaggtatt caggcatttt caaaacacca 2418661 tcgattttga aagaatcaat tccggcatct atcaattcct cgagctcatc aatgatgcac 2418721 acatcgttcg ggctcatgat gtgagtgccg ttttcatctt cgaaaatcgg atatttatta 2418781 tcgcgttctt tatcgtgtaa aaacatgcct gattcttttt tctttctttc aatgtccatg 2418841 actttgccct gatattcaaa atagtttcca atcaaagaac gcttcgattg gaacatgcac 2418901 gtcattccat gcacctggat ttcaatttcg acttcagcat tttctttaat ctcaacaatg 2418961 ctgtccatgt ttaattctct ggcaagcaca gaacgcgccg cacccttgcg tccccagtag 2419021 ttgcatgtat aatagttggt gcctgtcgtt tctgtgctcc aatgaagctt cagatcaggc 2419081 gcagattcac gggcagccat cagcacggca ggatcgccga ataccgctgc atcgacaccg 2419141 gcttctgcta agaaagccag atattcgcca agctcaccca ctttatcatt atggaaaatt 2419201 gcatttacag caacgtatac ttttgcccct tctttgtgag caatctctac ggcttttgtt 2419261 acatcttcac gagaaaattc tccggctaat ctcaagccgt atctctgttc cccaactaaa 2419321 aacgcagttg ccccagcctg tatgagcggc aaaatgtccg ctgtactcgt cggcgtcact 2419381 aagagctctg gttttttcat gacgttcacc tcttcttttt actaatcgca agtccgtccc 2419441 cgacaggaat aatcgcagtt tgataatccg gatgattcat cagccaatga ttatattcat 2419501 caattttggc tacaagcctg cgccttctct tcggttctat tttgctgtaa tcctctgcca 2419561 ccagaccttt aaacagcacg ttgtctgtta taatcacccc gtccggtgaa agcatcggtt 2419621 catataaatg aaaaaagttt tgatactgac cttttgcagc gtcaataaaa atgacatcgt 2419681 aaggcgcggt tacatgaacg gcgtcggcta attcaagcgc atctccgtaa aaaacatgaa 2419741 tccggtcatc aagctgaaat tccttgatat tgtttaccgc ttcttcatgc cgtttctcat 2419801 tgcgttcaat tgtatatatt tcagcagacg gcagttccag agccattcga atggctgaat 2419861 aaccaatggc cgttccgatt tctagtattt ttttcggctg tttcacagac aaaatttgaa 2419921 gcagcacctc catgcccgct ttttccataa tcgggacatg atgttcttct gcatatgctt 2419981 caagtctctt cacgttatcc ggccgaggct ttaataatgc ttctatatag tcatttattt 2420041 gttcataccg gtcagtcact acaaacagcc tcccgttcta aaaaggagtg ccccagtctt 2420101 atgcgcagga cactctctga atacatcatg atacatcggt aaacaacccg atatatttta 2420161 tcataaaacc ttgcggaaag cgaacaaaag gagagctttt tgctctcctt ttatttctca 2420221 ttttttgagg aaatgtattt ttcttttgct ttattatgct cttttagcgt ttttgtaaat 2420281 acgacctcac catttgattt ggccaagaaa tacagatagt ccgttttatc cggatgcagc 2420341 gctgcttccc atgatgacat gccggcattg gcaatcggcc ctggcgtcag ccctgtgttt 2420401 ttatacgtat tgtatggtga atcgatttcc agatccttat aaagaacccg atctttatgc 2420461 ttgcctgccg cgtacaggac ggtcggatct gtttggagcg gcattttctt tttcaggcgg 2420521 ttataaaaga cgctcgcaat tttatggcgg tcggcttttt cagtcgcttc ttcttctatc 2420581 aaagaagcca ttgtcagcag cttatgcaca gaaactttgt ttttcttcat ttctgattta 2420641 tatgtttcca cataagaatt tgtctgctta atcattgcct tgataatgtc ttcaagtgat 2420701 gtgtccggat cgttaaaagg gtatgtagcc gggaataggt acccttcaag cgggtgctta 2420761 atgtttttat tgaaaacatc atttgtcaca gtgtccggga attctttctt cagctgattg 2420821 ataaatgttt catcgtccag cttcgctatg acttgttttt tagagtattt tgtttcatca 2420881 gcaatagcag ccgcgatttg ggtcagctgt gctccctcag tcactgtgat ttgaaaagcg 2420941 taacctgtag ccccgcttgt cagcttctga ataatggcat ctaaatccat acctttattc 2421001 agatggtaga atccggcctg aaacccggaa gcacctttat atttcacata gtactgaaac 2421061 gccttctcgc tttttatgac atcatttttc tttaatatcg atgcgatggc tgaaacagac 2421121 gaaccgctcg gaatgttaat attaactgtc gttttactgt ctttttcaac aggttcaagc 2421181 aatgatttcc catataaaaa tgccccgcca atgatgagaa acagcacaac aatggaagac 2421241 agtatgattc tttttttatt aaaaaacgat tttttttgct gattgatata cattaggtct 2421301 cctcccatca gctcttatac tacatgattc attgtatttc ggcaatttat tacaaaaaga 2421361 ggcctgcata aagcagaaaa aagccggagc agtatagctc cggctttggt ttggcgcgat 2421421 gttttactct tcgtcttcgt ccgctaagaa tgtgtttagt gtttcttcga tcatatccca 2421481 ttcttcgtca gtttcaatcg ggaatagctc accgttttca ccgtcttcgt ttggcgtgaa 2421541 gctggaagca agaatttcta cttcttcgtc atcttttgat tcgattggat agtacaagac 2421601 ataagatttg ccaaactctt cattttcaaa tgtaaacagc acttcacaaa gctgttcatt 2421661 tccttgatcg tcaacaattg taatattttt ttcgccgtgt tccattttct tcacctctgg 2421721 ctttaattta agctgtcaag atatccttgt aaaatcataa cagccgccat tttatcaatg 2421781 actttttttc gtttttgcct gctgacgtca gctgcaatca gcattttttc agccgccatt 2421841 gtggtaagac gctcgtccca cagcacaaca ggaacattgt acgttgtttc aagcactttc 2421901 gcaaatgttt ggctggcttc gcctctcggg ccgactgttc cgttcatgtt cttaggaaag 2421961 ccgagcacga ttttatctat agtatagtcc tttatcagtt cagataaacg ggataaacca 2422021 taatcgcctt ctgcttcatt tatctttatg gtctcaatgc cttgagcagt ccagcccatt 2422081 tcatcgctca gagctacacc gagtgttttg gttcctaaat cgagtcctaa tattctcatt 2422141 ctttatttac gcctctttat gctgttctaa ataagacttt accaattcct cgattaattc 2422201 gtctctttca agtttgcgaa ttaaattgcg agcgtcacga tgcctaggaa tataagcggg 2422261 atcacctgac agcaagtatc cgacaatctg gttgattgga ttgtagccct tttcctgaag 2422321 cgcgtcatac actgtaatca gcacctcatt tacgttagtc tcagcagaat catcggagaa 2422381 attaaatttc atcgttttat caaacgagct caccgttttg cacctctttc ccaaattcgc 2422441 aggcaaagtt cagcctgggg tcctaatctt accatcattc tacactacat gggcgaatta 2422501 taaaacggat ttcacccaat cttctacaga agccaaagct tcttctaatt tttccggctg 2422561 tttaccgcct gcctgcgcca tgtccggacg gcctccgccg cctccgccgc aaacttccgc 2422621 agcttgttta accagcttgc cggcgtgaag tcctttctca atgaggtcct ttgtgactcc 2422681 ggcagagata ttaactttat cgttttgtac cgcaccaagc acgatcaccg cagagccaag 2422741 ctttgctttg agttcatcga ccatagtgcg gagatgattc atgtcttttg catttacttt 2422801 tgccgcaagc acgtttacgc cgtcaacttc ttttactttc gacaggattg ctcctgcttc 2422861 cacgttgcct agttttgcaa gaagagattc attttctctt tgtgcatcct tcagttcagc 2422921 ctgcagagcc gcgacccgtt tcggcacttc tttgatattt gttttcagct cgtcagcggt 2422981 ctgcttcaat acagaaatct ggctgttcat ttcgacgtaa gcgccttgtc ccgttacagc 2423041 ttcaatccgt cttgtgcctg ctccgattcc ggattcagaa acgattttaa acaagccgat 2423101 ttctgctgta tttctgacgt ggcagccgcc gcacagctct aagctgtaat ctccaacttg 2423161 aacgacacgg acaatatcgc catatttttc gccgaacagt gccatcgcac ccatttcttt 2423221 tgcttcagcg atcggtttca aatcaatgct gaccgggatg ctcgcccaga tcttttcgtt 2423281 tacgattctt tcaatttgtt cgagctcttc ttttgtcact tggccaaagt gcgagaagtc 2423341 aaaacgaagg cggttttccg ttacaagaga gcccgcctga ttgacatgag ttccaagaac 2423401 atcttttaga gcctgatgca ataaatgcgt tgccgtgtgg tttttaatga cgccgcttct 2423461 catatggtct tcaacttcag ccgtaacatg caggcctttt tgaacagtac cgctctccac 2423521 aacaccttca tgcacatgct ggccgttcgg cgctttttga acatctttaa ttcttacaac 2423581 tgcctgctcg cttcggagat agcctttgtc gccgatttgg ccgccgcttt ctgcatagaa 2423641 cggtgtttca tcaagaatga tttgaacgct ttctccttca tgagcctctt cgattaattg 2423701 gccgtcctga agaagcacaa tgatattggc atcagctttg gtttgagagt agccgacaaa 2423761 tgtgctttca actgtcacgt cgcgcagtgc gccgccctgc acctgcatgc tgccgacatc 2423821 ctggcgggcg tttcttgccc gttcacgctg ctggttcatt tcctcctcaa agccctcatg 2423881 gtcaaccgtc atgttctcgt cttctgcgta ttcttcagtc aattcaaccg ggaatccata 2423941 cgtatcatac agtttaaaca catcagcacc tgagataacg ctgctgccct tgtctttttc 2424001 ttttttgatc atttctgaca ggatcgcaag cccttcatta agggtctcat ggaagcgttc 2424061 ttcctcggtt ttaatgactt ttgcgatgaa atccgctttc tctttcactt caggatagaa 2424121 atcagccatg atttctgcga caaccggcac taaatcaaac atgaacggac gatggatgtt 2424181 gatcgttttg gcataacgca cggcacggcg taataagcgt cttaatacat agccgcggcc 2424241 ttcatttgac ggcagcgcac cgtcactgac agcaaaggca accgttctga tatggtcagc 2424301 aatcacttta aacgcagtgt ctttcacatt gtctttgcca tatgtttcac cagaaatcga 2424361 ttctgttgct ttaatgatcg gaacaaacaa atcggtgtca aagtttgtcg gaacattctg 2424421 gatgacagac accattcttt caagacccat gcctgtatca atatttttct ttggaagcgg 2424481 tgtgtacgtg ccgtcagggt tatggttgaa ctctgagaac acaaggttcc atacttccag 2424541 gtaacggtcg ttttccccgc ctgggtaaag ctccggatct tctggatcat taccgtatgc 2424601 ttcaccgcgg tcgtaaaaga tttccgtatt cggtccgctc ggcccttcac cgatatccca 2424661 gaagttccct tccagacgga taattctttc ttcaggaata ccgatttttt tcgcccaaaa 2424721 ctcatatgcc tcttcatctt caggatgaac cgtaacagag agaagctctt tgtcgaagcc 2424781 aatccacttg tcgctcgtta aaaactccca agcccatgta atggcttctt ctttgaaata 2424841 atcgccgatg gaaaagtttc cgagcatttc aaagaaagtg tgatggcgcg cagttttacc 2424901 tacattttct atatcgtttg ttctgatcgc tttttgagcg tttacgattc ttggattttc 2424961 cggcacgaca cggccgtcaa aatatttttt cagcgtcgca acaccgctgt tgatccaaag 2425021 cagtgaagga tcctcatgag gcactaatga cgcgcttggc tctaccgcat gtcctttttc 2425081 tttaaagaaa tccaaaaaca tttgacgcac ttccgcagaa gttaagtgtt tcattgtatt 2425141 tcctcctcta taaaaatcga aattctcttc agtgacagca aaaaagccct ccccctatgc 2425201 aaaccaacgt ttacacaggg acgagagctg tctcgcggta ccaccctgat tacgggcatt 2425261 catgcgcccg tcacctttaa ccctgtaacg caggataagc ggcagtgatt aactgcactc 2425321 aggattagct tcctccgatc ttctgataaa gctcctttca gcttatggag cttctctctt 2425381 taacagggct tcggcgtact cagatccgtc actcgagatt cgtatgtatt ctacgagaaa 2425441 ttatagacaa gcggcacgcc gatgtcaatg ctccgtcctc atccgcaaaa aatggatcat 2425501 cattactttt aaaacagccg tcgcaggaac agccagaatc atcccgacga tacccgcaag 2425561 ctcccctccg gcaaggagtg caagcatgat aacgaccgga tgcattttaa ggcttctgcc 2425621 gacaatgaac ggactgagga tatttccttc cataaactgc agaataaaca ccgtaatcac 2425681 cacaacaaga accgccttga ctgagatcgt catcgcaatt aacaacgcag gaacagctcc 2425741 gatgaaaggg ccaaaatacg ggatgacatt cgttacccca gagataaggc caagtatcag 2425801 cggatacgga agcccaaata cccagaacga aatgcctgca atcacgccaa gaatcaagca 2425861 gaccaaaagc tggccgcgga tataatcgcc aagcgaatca tccacatccc gcaaaaaggc 2425921 gctgccccgc tttctccacg acttcggagt caagtaccat actgtctttt tcattaactc 2425981 aatgtccttc accatataaa acacgagaaa agggattgtt gcagcaatta agaagtaatc 2426041 aagcacattg cggatcccgc tgatcgcacc ctcgatcgtt cccgcaaaaa acgcctccgt 2426101 ctggcggatc attttatcta tacggtgatg cataccatca ggccagtcat ccgtatggtt 2426161 atgcacatga agaagaagcc cgttatacgt ttcggcaaac atgggtatat tttctgacaa 2426221 atccgtcagc tgcacgatta aaacaggcac ccctttatac aacgcccagc caatcccgcc 2426281 aaaaaaaaga acataaatga ccaagatgct caaagtccta ggcaatcctt tgccatgcag 2426341 ccattctgtg accggaagca ataaataaga tataaaaata gaaatgatca agggaataaa 2426401 gatcgttttt atgacgagcc aaaagggtga ccataacata tcaagcataa aaaagacata 2426461 gactgttaac agaaccagca aacaaatagc cacccacaac aaaagctgca ccggtttttg 2426521 gagcatctgc tttcacctca cctatatctt ttgaggttta caaggaatta ttctttatgt 2426581 ttctttagtc agtcagaagt catggacatt ttttcacttt taattttcag aaaagtttga 2426641 tcatttactt tttggtcaaa ttttctgata ggaggattgc gatgatcaca tttcaaaatg 2426701 taaacaagca ttacggagat tttcacgtgt taaaacaaat taatcttcaa atcgaaaaag 2426761 gtgaagtcgt tgttatcatc ggcccatccg gttccggtaa aagcacattg ctcagatgca 2426821 tcaacagact tgagtcgatc aatgagggag tgcttacagt aaacggcacc gccattaacg 2426881 acagaaaaac tgatatcaat caagtgcggc aaaatatcgg gatggtgttt cagcactttc 2426941 atttatatcc gcataaaaca gtgctgcaga acatcatgct ggctccggta aaagtgctta 2427001 gacaatcacc tgaacaagca aaggaaacgg cgcggtacta tcttgaaaaa gtcggcatcc 2427061 cagacaaggc tgacgcctat ccttcccagc tttccggcgg gcagcagcag cgtgttgcca 2427121 tcgcaagagg actggcgatg aagccggagg tcatgctgtt tgacgagccg acatcagcac 2427181 ttgatcctga aatgatcggt gaggtgctag atgtcatgaa aacactcgcc aaagaaggca 2427241 tgacaatggt tgtcgtgaca cacgaaatgg ggtttgccaa agaagttgcc gaccggattg 2427301 tcttcattga cgaaggaaaa attttagaag aagcagtgcc ggctgaattt tacgcgaacc 2427361 cgaaggaaga acgggcccgc ttattcttaa gccgtatttt aaatcattaa aacagaaatg 2427421 ggggagcttg tatgaaaaag attttttctt tagcattgat ttctttattc gctgtcatct 2427481 tgcttgccgc ttgcggcagc aagggatcaa acggagaagc ctcaaaggag agcaaaaaag 2427541 atacgctagc cgccattaaa gacaatgaca aaattgtctt cggcgtaaaa acggacactc 2427601 gactgttcgg tcttaaaaat ccaagctcag gtgagattga gggttttgat attgatattg 2427661 ctaaacaaat cgctaaagac attttaggtg atgagaaaaa agctcaattt aaagaggtca 2427721 cctcaaaaac aaggattcct atgctgcaaa acggggatat cgacgccatt gtcgccacaa 2427781 tgacgatcac tgaagaacga aaaaaggaag ttgacttttc tgatgtctat ttcgaggccg 2427841 ggcaatcgct tctcgtgaaa aaaggcagca aaatcaagag tgtcgagaat cttggcaaag 2427901 gctcaaaagt tcttgcagta aaaggctcca cctcctctca aaacattcgt gaaaaggcgc 2427961 ctgaagcatc tgttttagaa tttgaaaact acgcagaagc ctttacagcc cttaaatcgg 2428021 ggcaaggcga tgccctcacc acagataatg caattttata tggaatggct gatgaaaata 2428081 aaaattatca attaacagga aagcctttta cagatgagcc ttacgggatc gccgtgaaaa 2428141 aagggcaatc tgctctcgcg aaagaaatca acgcttcact taaaaagatg aagtcggatg 2428201 gcagatacga tgaaatttat aaaaaatgga tcaaagaaga cccagctgaa taacaaccat 2428261 cccgggatga gcaggcgatg ctcatcccaa tttgataagg agtgaatagg cagatgaatg 2428321 tgtcaattct tttcgataac ttcagcatgt atatggacgg tttttaccat accttgctcg 2428381 caagtgttat cgcgctggcc ggcagttttg tcctcggcgt tgctgtagcg gttatgagaa 2428441 taacagtctt taagccgctg caatggctcg ggaccgcata tgtagaattc atccgcaaca 2428501 tccctcttct tttaattacc tttgttttct atttcggact tccaaacgca ggcctgaggc 2428561 ttgacggttt tcaagcggga acggttgctc tcaccattta tacctctgcg tttatcgctg 2428621 aagccatcag agcaggcatc cagtctgttt caaaagggca gatggaagcg gcacgctcgt 2428681 caggctttac ctacagccaa gccatgctcc atatcatttt gccgcaggca atcaaaatcg 2428741 tcattccgcc tttaggcaat caatttttaa acttagtcaa aaactcttcg attcttgggg 2428801 ttgtggccgg attggatctt atgtaccaag ccgatttagt ttcgtcgagc acactcgttg 2428861 tatttgatgt ttatattttt gtggcgcttt tttacttagt gctgacgatt ccgcttagca 2428921 tcggtgttaa ctatctggaa aaacggctgg aaaaaagcta ttgataagga gtgagttaca 2428981 ttggatttca tcggtgctta ttcacaggag catttagcgt ttttatggga tggctttctc 2429041 gtcaccttgt acgttgcttt catctccatc attctgagct ttttcttcgg tttaatcgca 2429101 ggcaccctgc gttatgcgaa agttcccgtt ctttctcaat tgattgcagt tctcgttgaa 2429161 acgatcagaa acctcccctt gctgttaatt attttcttta cgttttttgc ccttccggaa 2429221 attgggatta agcttgaaat tacagctgct gcaattacag cactaacgat ttttgaatcc 2429281 gctatgctat ctgaaattat ccgaagcgga ctgaaatcaa ttgacaaagg acaaattgaa 2429341 gcggcgcgct cctccgggct gagctataca cagaccctgt tctttatcgt tatgccgcaa 2429401 gcgcttcgcc gcatggttcc gcccatcgta agccagttta tttctttatt aaaagataca 2429461 tcgctcgctg ttgtgatcgc cctgcctgaa ctgattcaca acgcgcaaat tattaacggc 2429521 caaagcgctg acggcagtta ttttttcccg atctttttac ttgcggccct tatgtatttc 2429581 gcagtcaact acagcctttc actcgcagca agacgcctcg aggtccggca aacatagaaa 2429641 aggatactct ttggagagta tcctttttgc attaaaacat tttcgtaatt cttcttctca 2429701 tccgcttcat gcttcgatta ttcagcatgt cagattgagt cgccattcgg tacacgagag 2429761 ctccggctcc cattgccaaa agagaagtca tcgtccgatt catcctgcgc atctcctttc 2429821 atgattaaaa attgatgctg cgttcatcct cagaaaacaa atcatccaag ctgcttaacg 2429881 ttccgtcttc ttccacctga tgagttgcaa tcttcccttt cgccactgtc agttcaataa 2429941 aacagcccca gcaataatat tggttcacgc cgattttgcc gatatcctta cttttgcaat 2430001 tcgggcatat aagcatacct cacacctcta tccgttcaga acgatctcgt ctttccgcac 2430061 ctcgacaagc gaatccgctc tttggatctg gcgcttgctt cccgccaggt cagaaaagaa 2430121 accgtccgag agttcatatg ctacgattat gcccctgtcc aaacaaaagt atacatcttc 2430181 cagcatcccc aatatatccc cctcttgcga tttcacaagc ttcatcttca tctgctcgta 2430241 tgtgaagcat gatttcggaa gaggcaaaag ctgttctgaa ctgaccgaag ccaatatgcg 2430301 gtcatcaaaa atggaagaga tatcacacgc ccgtaatagc gcatgatgat gatgcaaaaa 2430361 gcgtttttgt gcaagaataa acccaagaca atctcctttc agagaaaaac aaatatcgga 2430421 aattgtcccg agataactag aagttcgttc tgagtatact gggaatcctt ctacttcatg 2430481 gcatgttctc aaagtgtgat caaccacctt ttgttgaaca ggcttaggtt ttgctttgcg 2430541 ccttagactc atacgatgaa atcaattcca ctgcaaatga aaaaaaactc ccgcttgcac 2430601 gggagcattt tattgctgtt cttctttcat aaaatcgaat ggtgtaatgc cttccatgcc 2430661 aatgttggcg tcgtgtacgc tgaacgggag ctctttttgc aaagcttcaa gctcggcatc 2430721 catttcctca acctgtacgg acagcctgtt tttcaaggag gtctgtctga cagttgcatc 2430781 attatttttc acgccccact ccagcgcctc ctcttccccg cataaaatga gaaatttctt 2430841 cgctcttgta atcgcggtat aaagaaggtt tcttctgagc attctataat agcctttcac 2430901 aacaggcaaa accacaatcg gaaattcact tccctgcgat ttatgaatag aacagcaata 2430961 cgcatgggta aattgattaa aatctttttt cgtaaatgtc atttcattgc cgtcaaaaga 2431021 aacgacggcc atgtcttctt tttctgtatt ttcctttgca taaaatatcg acgtgatttc 2431081 gccaatatct ccgttgaaca cattgttttc cggctgattg acaagctgca aaattttatc 2431141 tccggttctg tagacaacat ccccgaactt caattctctc cgtttttctt taggaggatt 2431201 taaaatgtcc tgcagcatca cattcaattc attaatgccg gcttttcctc tgtacatcgg 2431261 agcgaggacc tgaatgtcct ttgctgtata gccttttttc aatgcattgg cgacaacctt 2431321 ctcaactact tctttgattt gcgacccgcc gcagcgaata aaggaacggt cctttgtcgg 2431381 ggcagtcaaa ttgttcggca gcaatccatt tttcatctgg tgggcaagct cgacgattga 2431441 tgacccttct gcctggcgat agatgtctgt cagtctcaca gtcggaatca cctgggatgc 2431501 cagcaggtct ctgagcactt gtcccggacc gacggaaggc agctggtctt cgtctccgac 2431561 aatgatgatt tgtatatgat cagggatcgc cttgaacaaa tgattcgcca gccatatatc 2431621 aagcatactg gcttcatcga taattaacag cttcccttcg atcggctgat cctctgtatg 2431681 agtaaagcct tcagcgccgt tccagccaag cagcctgtgt atcgtaactg cagggagtcc 2431741 cgttgattca ctcatccgtt ttgctgctct ccctgtcgga gcggccaaaa caatcggaaa 2431801 agcttcatcc tttttataag ctgacgggtc tagtgacaca ccgtgaagct ctccgtagag 2431861 ctcgacaatc cctctgatta ccgtcgtttt tcctgttccc gggccgcctg ttaaaagaag 2431921 catcggcgag gaaagggctt tttgaatcgc ttccttctgg ctgggggcat actgaacgtc 2431981 catccgttct tccagttctc ccaacgcgag caaaaactct gattcgggaa actggttctc 2432041 atattcggtt tggctagcga tatgtttcac acgctttgca acgttttgtt ctgcgtaaaa 2432101 cagcgaagga aaataacagc ggccatcttc tatgacaatg tctttatttt ctccaagggc 2432161 aataattgcg ttagcggcat ccatttctgt aatgcgctgc ccttcccttg ctgactggtt 2432221 taacagtgat tgagtgtcga tgatcagctg ttccgtttct atgtacgtgt gcccctctga 2432281 cagacaagtc gtttcaagcg tgtacaaaat agcagctttt acccgctcag gatgattacc 2432341 cgaaagaccc attctgctgc ccagctcatc cgcttttcca aacccgatgc cttctacatc 2432401 cttcacaagc tgataaggat tttcctgaat cttttcaagc gtctcggatt cataggcttg 2432461 atagattttc atagacagct gcgggccaaa gccaaactga ttcaaggaaa tcatgatttg 2432521 ctccagtccc tgatgccgct gcaatgcgcc agccagcgtg tctgctttct tttttgagag 2432581 tctgggaaca tcataaagca ctgaagcatc agccaatatt ttattaatgg cgctgtcgcc 2432641 cagctttttc acaatttctt cagctgtttt tttgccgatc ccctcgaata aatcactcga 2432701 taaatattga atgatgcctt ccttagtcgt tggaatctcc tttttgaaat gctccgcctg 2432761 aaattggagc ccgaattttg gatgggttac gatctttccg taaaacgtgt aggtctcttc 2432821 ttcttgaagc gcagggaagt agcccgtcac ggatacggct ttatcttcaa tggcttcgga 2432881 ggtctctgtg actttcactt tcagaaccgt atataaattg gtgtcattat gatagatgac 2432941 tgtgttgact gtccctttta aatagggctc ttcctccagt ttaagctgat ccggatgctg 2433001 ctgcacgagc tgtccctcct cctgtgcctg ttatgatgga tcaatcagtt ttttagcatg 2433061 aagcgcaagc atatgatctg gctggatatc gattgccttg tccagcattt ccagcgcttt 2433121 ttctcggttt tctttataag cataagtgac accggcatta taaaatgcat ctgcatgccc 2433181 cgggtcttgc tctgtcacag ctgcgaattg gctgagcgct tcgtccagca tgccctcgtt 2433241 ggctaagcac atcccgaatt gaaaacgcgc ttccgtatcg ttttcattca gttcgactgc 2433301 tctttgtaaa tatggcagtg caagcttagg ctgttcgagc ttgacaagta ccgttccgag 2433361 catgtaaaac aggtcgccgt tttccatccc cgcacgtagc gctttttcaa acatgtcttt 2433421 cgcttctttg tacatttctt ttacaacata gacatttcct gctccataat aagcagtggc 2433481 tgcgctactg tctaattcaa gcgctttatc ataaaacgca agcgcacgtt ccagctcgtt 2433541 tacggatgaa agaaggttgg caaaattgat atacggaatc gcgtcttctt tattttcttc 2433601 aatcgctttt gtaaatgcct ctgccgcttt ctcgtaatcg ccttcctgca tcgcctctat 2433661 accgagttga ttataatcca ccgatcatct tcctttcatt aaaaaacccc aactcagtgt 2433721 tgaggttttt catcttttat acgtaccaca attttgttcc gtctttgtac acatcatcaa 2433781 ttgtcccgcc gccaaggcat tcttcgccgt catagaagac aacggcttgt cccggcgtta 2433841 cagcgcggac ttgttcatca aagatgactt ccgcttcacc ttcgccagtc atgcgcactg 2433901 ttactttatg atcctcttgg cggtaacgga atttagccgt gcaggaaatc tcttcgccct 2433961 tcatgatatc cgaacgtacc cagctgatat ttgttgctgt gattttgtcg gaatataaaa 2434021 gcgggttatg gaacccttga tctacgtaga ggatgttctt ttcaagatct ttgcctaccg 2434081 caaaccacgg ctcgccgctt ccgccgatgc caaggccgtg acgctgtccg atcgtatagt 2434141 acatcaaccc gtcgtggcgg ccttttactt cgccgtccat cgtcatcata tcgcccggct 2434201 gtgcagggag atattggctg agaaacgttt tgaagttgcg ttcgccgata aagcagatgc 2434261 ctgtactgtc ttttttcgtc gctgttgcaa gttctgcttc tttggcaatt tcacgcacac 2434321 ggcttttttg aagttcgccg atcgggaaca tgactttgct cagcgtatct tctgtcagct 2434381 gattcaggaa gtacgtttga tccttgtttt catcaatgcc gcgcagcatt ctgacttttc 2434441 cgccgcttct gtctactctt gcatagtggc cagtcgctaa atagtcggcg ccaagtgaca 2434501 atgcatgctc caaaaaggcc ttgaatttaa tttctttgtt gcacaataca tccgggtttg 2434561 gtgttctgcc tgctttatat tcatcaagga agtattgaaa taccttctca taatattgct 2434621 tttcaaagtt tacggcataa tacggaattc cgatttggtt gcagacgcgg atcacatctt 2434681 cataatcctc tgtcgccgtg caaaaaccgt tttcgtccgt atcatcccag tttttcataa 2434741 agattccgat tacatcatag ccctgttctt ttaacagcag ggccgccaca gatgagtcta 2434801 ctccgccgga catgccgacg acgactcttg tatcctccgg ccgtttttcc atttcattca 2434861 ctccaattac tacgccgcct tattatgtca gccgtttgac aacgtcggcc acatgtttgg 2434921 cagcagtttt cacttgctca gccgtattgc cgaggccgaa gctgattcga atagaggacg 2434981 tcagccggtc actctcttcg ccgaacatag cagtcagaac atgtgacggc aggactgaac 2435041 cggccgtgca cgctgaaccg ctggagacag cgacaccagc catatcaaga ttaaccagca 2435101 gcgcttccac tgacacaccg gggaaataaa gattcagaac atgcggcaga ctatgctctt 2435161 tgtccccgtt gacctcgaat gccacacctg catctctaag cgtgtcggca aagattgctt 2435221 taaacgattg atacttctcg tttttttcgt cacgttcttc acttgacagc ttgatcgctt 2435281 ctttcagccc gacaatgcct ggaacatttt ccgttccggc acggcgtttt ctttcttgct 2435341 ctcctccgaa taaaaggggt gaaagcttca catctttact agcatataaa aagcctgtcc 2435401 cttttggccc gttgagcttg tgcccggaaa cagacagaag gtcaatatgg ctgtttttca 2435461 catcaattgg cagcaacccg aatgcctgaa cagcatcggt atgaaaataa gctttgtgtt 2435521 cctttaacag ctcaccgatt tcttcgatcg gctgcactgt tccgacttca ttatttccat 2435581 acatcactgt cacaaggatt gtatcatcac gcagtgcttc tttcacctgt tttgcactga 2435641 ctcttccatt ttggtcaacg tccagatacg ttatgtcaaa tccgtctccc tcaagttttt 2435701 cacatgtgtg aagcacggcg tgatgctcaa tttttgttgt gatgatatgt ctgccaagat 2435761 cttttcttgc aagtgcggtt cccatgatcg ccaagttatc agcttccgtt cccccgcttg 2435821 taaaaatgat ctcctgctct gccgctccga tttctgctgc gatctgcgct cttgcttcat 2435881 ccacccattt tcgagattct ctgccaaatg aatgaatact ggagggatta ccgaaactgc 2435941 cggagaagtg cggtatcatt tgttccagca cgcgctcatc catcggagac gttgcggcat 2436001 gatctaaata aatccgttcc attatgttta cacctctgat ctaaatatag aacatataag 2436061 cttcttgctc tccgtctgta tagctggcaa gatcctctaa tgttgtactg tctaaaacct 2436121 cttttacagc atcccggatg cgaatccaga gctcacgctt ggcaggctcc tcatcttcca 2436181 gcacttcaac agggctgatc ggcccctcaa gcacacggat aatatctccc gcagtaatgg 2436241 catccggctc actgcctaat acatatccgc catatgcgcc tctgatgctt ttcactaaac 2436301 cggcatttct gagcggcgat accagctgct ccaaataatg ctcggacaaa ttattcgtct 2436361 gtgcgatgct ttttaatgaa gtcgggcctt caccgtgctt ttttgcaagc tcgatcataa 2436421 tggtgagccc gtatcttccc ttagttgata ttttcaacat gaacacctct gttatttcat 2436481 gattttccac atttataatg gtaatttcta tatgtttcgt ccgtttatta tcttatagac 2436541 caactgttat tataacatac cttcagcgaa ttttcattga ggcagaagga aaggggcctt 2436601 tacccttttc taatgtacgg ttttccgtta ccctgtaatt aagtaaggag agatgataga 2436661 tgaagccatt ggcatatcgg atgcgtccga caaaaataga ggatattatc ggccagcagc 2436721 atctggtggc tgaagataaa attattggca gaatggtcca ggcaaaacat ttgtcatcca 2436781 tgattttgta cgggccgccc ggaattggaa aaacatcaat cgcaacagca atcgccggtt 2436841 caacaagtat tgcttttcga aagctgaatg ctgtcattaa caataaaaaa gatatggaaa 2436901 tcgtagctca ggaagccaag atgtccggcc aagtgatttt gattctggat gaagtccaca 2436961 ggctggataa aggaaaacag gattttctat taccctattt agaaaacgga atgatcattt 2437021 tgatcggagc aacgacggct aacccgtatc atgccattaa tccggcgatc agaagccgga 2437081 cccagatttt tgagcttgaa ccgttaacac ctgaactgat taaacaggca ctggaacgtg 2437141 cgctccatga tgagcatcgg ggccttggca cctattctgt atccattgat gatcaggcga 2437201 tggagcattt tgcccacgga tgcggaggag atgtccgctc cgctttaaat gcgcttgagc 2437261 ttgccgtgtt gtcaacgaag gagtcagcag acggtgaaat tcacattaca ttagaaaccg 2437321 cggaagaatg cttgcagaaa aaaagctttt ctcacgataa agatggtgac gcgcattatg 2437381 atgtactgtc cgcttttcaa aaatcaatcc gcggctctga tgccaacgct gctcttcact 2437441 atttggctag attaattgaa gccggtgatc tggagagcat cgcaagacga ttgcttgtta 2437501 tcgcctatga ggatatcggt ttagcaagcc cgcaagccgg ccctagagtg ctgaacgcta 2437561 ttcagaccgc tgagcgagtc gggtttcctg aagcgcgaat cccgctggcc aacgcagtta 2437621 ttgagctttg cctctcaccg aaatcaaact ctgccattct ggcaatcgat gaggccctgg 2437681 cagatatcag agccggaaaa attggggatg tcccgaagca tttaaaagac gcgcattata 2437741 aaggagctca ggaattagga agaggaatcg actataaata cccgcacaat tacgacaacg 2437801 gttgggtcga acaacaatac ctccctgatc ctctgaaaaa taagcaatac tataagccga 2437861 aacagactgg aaagttcgaa tctgccttaa agcaggtgta cgataaatta atgaaaagaa 2437921 aataaaacaa aaaaacagcc ttgatcatca aggctgtttt tatgcattat ttatccttca 2437981 cacgtttgat ttcaatgtct ttcaaaagat ccatgacaac atgtccgccc ataatcaaac 2438041 ctgcaactga cggcacaaaa gcattagagg aaggcggcat ttttgcttta cgtattttcg 2438101 cttcgtcatt ccccacttct tttctgacat cttcccgaat aacaatcggg ctttcatcag 2438161 agaaaatcac ttgaacgcct tttttgatac cctccttgcg taatttcgta cgaacgacct 2438221 tcgcaattgg atcagtgtgc gtttttgaga tatcagcgat ttggaagcgt gtcggatccg 2438281 ttttatttgc agcacccatg ctggagatga gcggaatatc ccgttttaga cattctttca 2438341 ttaaatgaat tttataacaa atggtgtctg acgcatcaat gacatagtca agaccatagt 2438401 caaaaaactg ctcatacgtt tcctccgtat agaacatttt taacgcgatc acttcacact 2438461 ccgggttaat gtctgcgatc cgcgccttca ttaaatcaac tttcggctgt ccgacagttg 2438521 aaagcagcgc gtgaagctga cgatttacat ttgtaatgtc gacatcatct ttgtcgacaa 2438581 gcagaatgcg gccgacgcct gaccgcgcga gagcttccgc cgcgaacgac ccgactcccc 2438641 cgactccaag cacagcaact gtgctgtttt tcagcgtttc aaggccttct tttccgatag 2438701 ctaattcatt gcgtgaaaac tggtgtaaca agaacctcac tccacattcg tattctggtt 2438761 tcatctataa aatggctgat ccatgagcag ccgttttttc tgcgcacaaa aaataaagtc 2438821 ccaatagtgc cgttgcagct ttcctttgtt ttgaacccgc tctcagcagg tgggtgccct 2438881 cttttaaatc ttgtaagtcc tctttaccga atgaaaagag gcatgtacgc catttaaaaa 2438941 tgcgggctcc caaatcaaaa aaatgttcgg tcaaaactag gtgtacaact aacacatcag 2439001 gactttattt aacttgtcaa aatcatatca cagacgattt tgattttcaa gaatcgaact 2439061 gcaaattcag ttcttaactt ttttcttgat agaaagatga agctcgtcaa gctgggcgtc 2439121 gcttacttcg cctggcgctt ctgtcatcag gcagcttgca cttgccgttt tcgggaatgc 2439181 aatcgtatct ctcaggttcg tacgtccagc gagaagcata acgagacggt ctaagccgag 2439241 tgcgattccg ccgtgcggag gagcgccgta ttcaaatgct tccagcagga atccgaactg 2439301 ttcagccgct tcttctggtg agaagccgag aagcgcaaac attttttcct gaatatcctt 2439361 ttcgaaaata cggattgaac cgccgccaag ctcatagccg tttaagacga ggtcataagc 2439421 ttgcgctttc atgtcttcag gcgctgtttc aatcagctca aggtcttctc ggacaggcat 2439481 tgtgaacgga tggtgcgctg cgtaaaaacg gccttcttcc ggatcatgct ctaatagcgg 2439541 ccagtcgatg acccataaga aattgaacaa tttttcgtca atcagtccgc gttctttccc 2439601 aagctttaag cgcagggcgc cgagtgatgc ggccacaact tcgaattgat ccgctccgaa 2439661 cagcagcaaa tcaccttcag cagcatcaag tgcttcaatc agcttagact gcttttcttc 2439721 atcaaagaat ttagcgatcg ggcctttcac tccgtctgcc tcaaccttca cccaggcaag 2439781 cccttttgcc ccgtagtttg cagcaaaagc gccaagagcg tcgatgtctt ttctggagta 2439841 atcgccggca ccgcctttta cattgatggc tttgaccacg ccgccgtttg ctacagctga 2439901 tgagaacact ttaaattccg tatcctttac aatgtcagac acatccgtca aaagcatgtc 2439961 aaaacgcgta tccggtttat cagacccgta cttgttcatt gcttcgtcat acgtcattcg 2440021 aggaagagga agctgaagtt cctcaccttt tgtttcacgc ataacctttg ccatcatctc 2440081 ctcagccaat gacataatgt cttcctggct cataaaggac atttcaatat caatttgcgt 2440141 aaactcaggc tgacggtccg cacgcaagtc ttcatcgcgg aaacagcggg caatttgata 2440201 atatcgttca atgcctgata ccatcagaag ctgtttaaat agctgcggag actgcggcag 2440261 cgcgtagaac tcaccttcgt gcacacggct cggcaccaag tagtcacgtg cgccttcagg 2440321 cgtgcttcct gttaaaatcg gcgtttcaat atcaagaaac ccattttcat ctaaaaagct 2440381 gcgaacagct ttcgtcacgt tatggcgcag ctgcatcgtc tggaacatag ccggtctgcg 2440441 caaatctaag taacggtgtt ttaaacgaac gtcctctgac acttcttcag cttgatcaga 2440501 aatcgcaaat ggaggtgtct ttgcagcatt taatacgttc actccatcag catgtatttc 2440561 gatcgcgcct gttttcaaat tcggattaac tgttccctct tcacgcgcca ccacttttcc 2440621 ttgaatatca agcacgtatt catttctgat gccttccgca atagcaagcg cttcttttga 2440681 cacatcaggg ttaaaaacga cttgaacaat gcccgtacgg tcacgcaagt caataaaaat 2440741 caatccgccg aggtctcgtc ttttttggac ccagcctttc agcgttacag attcgccaat 2440801 tgctttttca gttatatcac cgcaataata tgttcttcca aacaatgcgt ttcactcctt 2440861 atcccttttg gtttgccttc atcacatgta taaattcatc aagtgccact tcaatctgtt 2440921 cgcccgtctg tgcatccttt acattgattt tgttttgggc aagctcatct tcacccaaaa 2440981 tcgcaataaa tctggccttt aagcgatcag ctgttttaaa ctggcctttc attttcttat 2441041 tttcataatc gatttcactg gaaatgcctg cttctctcag tttgtacacc aatgaaacag 2441101 aataatcctt tgctttttcg ccgagtgtga cgatatagca gtcgattccc ttatcaacag 2441161 gcagctctct tttttcagca tcaattgcgg caagcaagcg ttcgatgctc atcgcaaatc 2441221 cgatgcccgg tgcttcaggt ccgccgatct gttcgacaag cccgtcgtag cgtccgccgc 2441281 cggcaagtgt cgtaatcgcg ccaaagccct ccgcattgct cataatttca aatgcggtgt 2441341 ggttgtaata atccagccct ctcacaaggt tcggatcgat ttcatacgaa atgccaagat 2441401 catttaagta ttgtttcact ttttcaaaat aagcggctga ttcttcattt aaatatgtca 2441461 aaatcgaagg tgccgatttc atcagctcat gatcacggtc ttttttgcag tccaaaattc 2441521 taagcgggtt cgtgtgcagc cgggactggc agtctgaaca aaattcttcg atgcgaggct 2441581 cgaagtgttt cacgagcgct tctctgtagc ttttgcggct atcttgatcg ccgagactgt 2441641 ttatgacaag cttaacgttt tctaaacctg ctttttcata aatactcatc gcaagcgcca 2441701 ttacttcagc gtcgattgca gggtctttcg aaccaatcgc ttcaattcca aactgataaa 2441761 actggcggta acggcccgtc tgaggacgtt cataacggaa catcggcccg acataataaa 2441821 gctttgtcgg ctgtacagga tttgcgaaca gcttgttttc attaaaagcg cgaaccgcag 2441881 cagctgttcc ctccggacga agcgtcaggc ttctgccttt gcggtcctcg aaggtataca 2441941 tttctttttg tacgatatcc gttgattctc cgacgcctct ggcaaacagt tctgtatgct 2442001 caaaaatcgg tgtgcggatt tctttatatt gataagtgcg gcaagtgtct ctcataattt 2442061 gttcaacaaa ctgccagcga tctgattctc caggcagaat atcctgtgtt cctctcggaa 2442121 tgttatatcc cataggtaga cctccttatg tattccttat aaaatatcca atgatcgtta 2442181 atgatgaaaa tgaaaaaaac tcccgcccct actatacatg atagtaggga cgagagttat 2442241 acccgtggtg ccaccctagt tggaatacgt tcatattccc gctcgatcct ttaacgcagg 2442301 ttcacgttca ctgcctaatg gcgttattca cgcgttcagc aggaaacctc cggagtgttg 2442361 tttcgagaaa gacgcaatgg gatccgcttt cagcctgggg cgggttcctc tctaatcatg 2442421 caatctgacc tactcttctc cattattggt tcaaatcttt catcatttgc tatgtactca 2442481 atttctatta taataatggg attggggttc tctgtcaagc tttattccgg ttgtttttcc 2442541 tcagcgctgc ttctttggac ataagaccaa attcagatgc tgtttccgta agataaccag 2442601 tcgtatcggg atctgcgtga tcgctgtaat gcagattcgc ttcaccgtcg tgaaatgcac 2442661 gtcccatttt tggatgatat ttcatgattt gcacaccttt ttgattgtat ttacgcttag 2442721 tataaacaaa tcattttatt tttatttaaa aatcagaaag gactttacga tattaaacaa 2442781 gaatgctttt ttaatgatca tcagaaagga ggacacaatg aacaagaaat actttgtcct 2442841 tattgtatgt attattttca cctcagcgct attcccgacc ttttcatccg ttacagctgc 2442901 tcaaggagaa gcggtcatcg caacagatga aatgaacgtc agaagcggcc cagggcttag 2442961 ctacggcatt acagcggaag taaaaaaggg agaacgctat ccaattttaa aggaagatgg 2443021 agactgggtg cagatacagc ttggttctgg agaaaagggc tgggtagtct cctggcttat 2443081 tacaaaggaa gaccaggcca gcacaagctc ctcaggaagc agtgacactg tgacatcaac 2443141 agaccccgat ctgcggatga gaagcggccc gggcacttcc tacgaagtca tcggcaaatt 2443201 cccgcaaggc agccaagcat ctgtcattga taaagattcg ggctggatca agatatccta 2443261 tcacagtgcc accggatggg tatcatctga atatgtcaca tcaggaggca gcagttcagc 2443321 gtctgatgag agtgaccaaa ccgaggattc cggtgcgtca acgacgggca cagtcggtgt 2443381 ttcttcgcta aatgtaagag cctccgcctc acatgacgcg gcaattataa caaaacttga 2443441 tcgcggaacg aaactgacgg ttctcaacga gaaaaatggc tgggctcaca ttgaggtgaa 2443501 cgggctaaaa ggctgggttg caagccatta ccttttgact agttctgttc cagctgatga 2443561 ttcagcaaat gccggcagtt catcctccgc taaaaaagcc tatatcatgt acggaggaac 2443621 gaatctaaga agtgatgcgt caacatcagc ttcgatcgtt gagcgcgctg ccaaaggaga 2443681 ttcatacacc attaccggtt caaagggaag ctggtatgaa ataaagcttg ataacgggca 2443741 gactgcttat gtagccaatt gggtggtcca aacgtctaaa agcgcagaag aagcaggtga 2443801 accgccagtc tctgattccc cgtctggaaa cggctctcta aacaataaaa cgattattgt 2443861 tgacccggga catggaggaa aagacagcgg aacgatcggg tattcgggga aattcgagaa 2443921 aaacctgacg atcaaaacgg caaaactgct cgccagcaaa cttagatcgg ctggagcgga 2443981 tgtatatgtg acacgccagg atgatacctt tgtcagcctg cagtcacggg tctctacctc 2444041 tcactaccgt aacgctgacg cctttatcag cattcattat gacagctatg cggatacctc 2444101 tacaagaggc agtacagcat attactacag tcctgccaaa gatcaggaac tcgcatcaga 2444161 tgtccactca gaagtggtga agcgttcttc cattccagac cgcggcgtat tattcggaga 2444221 ttattatgtg ctccgggaaa acagacagcc cgctatgctg tacgagctgg gatatgtaag 2444281 ccatccgcag gaagaagcca ttgtacatag caattcatac caagaaaaag taacagatgg 2444341 gatcgaaagc ggattagaga aatacttcca ataaaaaaag ctgccttttg gcagcttttt 2444401 ttattttgaa tccataatga gcgtgaccgg tccggagttt gtaagctgaa catccatcat 2444461 tgctccaaac gttccggtct ccactttgat tcctttttca cgaagcaggt cattccattt 2444521 ttcataaaga cctaaagctt tatcaggttt ggccgcgttc atgtagttcg gccggcgccc 2444581 ttttttcgta tctccataaa gcgtaaactg tgagacggat aaaatctctc ctcctatatc 2444641 tacaagagac agattcattt tcccttcact gtcatcgaaa atacggagat tgacaacttt 2444701 atcggctaaa taagctgcat catcttctgt atcatcgtga gtgatgccga ccagcaccat 2444761 aaggccttgt ccaatttggc cgacgacctc ttcgtccact gtaacgcttg cttctgttac 2444821 tcgctgaaca actaatctct tttctaaccc ctttagttca tgacgcggcg cacagaatag 2444881 atatctctaa tctgtttaat acgctcgacg actttatgca agtgattgat attctggata 2444941 aaaatcgcca tatggatggt tgccacttta ttgcgatccg atttgccaga gacagatgaa 2445001 atattggttt tcgtttcatt cactgcctgg agtacctcgt tcagcaatcc gcggcggtca 2445061 tacccaagaa tctctatctc aacattgtat tccttgcgct tttgaacttg tgactcatgt 2445121 tcccactcta ccgggatcag ccgctcttgg gcttcattcg ttttgacatt cggacagtct 2445181 tcgcgatgga ccgaaacccc tctgcctttt gtgataaagc cgacaatatc atcacctggc 2445241 acaggattgc agcattttga taaacggaca aggaggttgt caatgccctt gacacgaacg 2445301 ccagcttccc gttttcttcc ttgcgggtat ggcttaggtt ccccagtgac ttcctgaacg 2445361 atcttttcct gttcttcctg gtcgcgctgc tttctctctt tttctgttag gcggttcgcc 2445421 acctgcagag ctgtgatgcc gttgtaaccg accgccgcgt acatatcctc ttcatttgag 2445481 aaattaaatt tgtcagcaac cttttgaata ttctccggcg ttaaaacatc cttcaattca 2445541 aaatccaagt ttttaatttc tttttcgacc agctcacggc ctttttcgac attttcttca 2445601 cgccgctgtt tcttaaagaa ttgacggatt ttatgcttcg cttgggatgt ttgggcaagc 2445661 ttcacccaat cctggctcgg accgtaggaa tgcttagagg tgagaatttc aacgatatca 2445721 cctgtccgaa gcttatggtc aagcgtaacc atttttccgt ttactttggc accgattgtt 2445781 ttattgccga tttcagagtg aatccggtaa gaaaagtcaa tcggaacaga accggacgga 2445841 agctcgatta catctccttt tggcgtaaag acatacacca tgtcagagaa caaatcaatt 2445901 ttgagcgatt ccataaattc ttctgcatct gtcgattcat tttgaaattc taaaatttca 2445961 cggaaccaag aaagcttttt ctcaaaggtt gcaccttcat tggctgcttt cccttcttta 2446021 taagcccagt gagccgcaac cccgtattcc gctatttcat gcatttcaaa ggtgcggatc 2446081 tgcacttcaa gcggatcgcc tttaggccca ataaccgttg tatgaagcga ttgatacata 2446141 ttcggcttcg gcattgcgat ataatctttg aatctgcctg gcatcggttt ccagcatgtg 2446201 tgaatgatgc caagcaccgc gtagcagtcc tttatgctat tcacaagaat acggacagcc 2446261 aacaaatcgt aaatttcatt gaattgctta ttttgcagca ccatttttcg ataaatgctg 2446321 taaatatgtt tcgggcgtcc cgagaagtca gccttgatat ttacttcttc gacacgtttc 2446381 ttcacttcat tgacaacctc atcgacataa agctctcgtt ctgcacgttt cttcttcatg 2446441 aggttgacaa ttctgtaata ttgctgaggg ttcaaataac ggagcgccgt atcttccaat 2446501 tcccacttaa tttttgaaat cccgagacga tgcgccaaag gagcaaaaat ttccagcgtt 2446561 tcattggaga ttctccgctg tttttcctga ggcagatgtt tcagtgtccg catattgtga 2446621 agacgatccg ccagcttgat caatatgacc ctgatatctt gagccatagc gacaaacatt 2446681 ttgcgatgat tttccgcctg ctgttcctct tgagatttat atttaatttt gccgagtttc 2446741 gttacgccgt ctacaagcat tgccacttct tcggaaaatg cttctttcag gtcatcgagc 2446801 gtcacatctg tatcttccac gacatcgtgc aaaaatccgc ccgcgattgt ggaagggtcc 2446861 atttcaagat caacgagtat ccccgcaacc tgaatcggat gaataatata tggctcgccc 2446921 gatttgcggt attgctcgcg atgagcatct tcagcgtaca gatatgcttt ttcgacaaat 2446981 gcgatatgct catcagatag atagctgcgt gctttatcta taacttgctc ggcagtcaat 2447041 acttgttcgt tcgccatgga atcacctttt ttaaaatgta aactgtattg tagtttatta 2447101 tcaagaaaaa aacgaaagat gtaaagagca gaagttcaaa tagccaaata ttatataaaa 2447161 taaatgcaaa acaataggaa aaaagcaccc tgacatggag tgctttttcg ttatgcggtt 2447221 atccttagta tttcatcaat gttaagatgt cgtaatcttc gagcttattt ctgccgtcaa 2447281 ggtaagaaag ctcgattaag aaagcgatac cagcaacaac gccgccaagt tcttcaacaa 2447341 gtttgattgt cgcttcaatt gtgccgcctg tcgcaagcag gtcatctgta ataagcacac 2447401 gctgaccagg cttaatcgca tctttgtgga tcgttaatac gtcttttccg tattccaagc 2447461 cataatccac tttgattact tcacgaggca acttgccttc tttgcggacc ggcgcaaaac 2447521 ctacgccaag cgcgtaagca acgggacagc cgataataaa gccgcgcgct tcagggccaa 2447581 cgaccaaatc aatttgcttt tctttcgcat attcaacaat ttgatctgtg gcatagcggt 2447641 atacatcgcc tttatccatc agtgtcgtaa tatctttaaa ttgcacgccc tctttcgggt 2447701 aatccggtac aattgttacg tattgtttta aatccatctg ttttatgtcc tcctcgtact 2447761 ttcataagcc tctgaatctt gtttcatcag cttattcagc cattccttca gctcttcagc 2447821 agaagaataa ttcagctttt gatccagttc catcagctgc tgtttcgcct gatatgtttg 2447881 tgagtctgtt aagtcgcgtt tctttgctcc gctcacaaca gacagcacac cattctctat 2447941 tttaacaaaa ccgagatcaa aaaacacctt tgtcatgaaa ttgattgttt caacggacca 2448001 gcctttatgt tttgcaagct ctgaaccgtg ttttttcacg tcaaaagcgc ctcttttcag 2448061 caagaacgca taataccatt taaagtggtc tcttgcggga aaagttgata aaaagtggtc 2448121 ctcatgattg agaaaaataa aatatatccg ctcgggcgcc tttccttcca gcaaacgtgc 2448181 gagcatgtcc agcgaaggcg gcggatccag taatacaata tatgcaccat cgaggtcaaa 2448241 cgcctttgct tgatctttag aactgatgac gtgcacttct cggcgaaggt cttcagtttg 2448301 aagtaatgtt gttgagtctt ctttgaaaga gacaatggcc cgtttagcag atggaagggc 2448361 ggaaactgtg tcttcccacg tccgttttcc ccttaaatca aacagctgcc attcagaaac 2448421 agcggcatcc tttatcataa gctgcggctt ttttcgattg ttccattcgt tgattgacat 2448481 ctcaccgaca atggaaattc ttgaacccgg tacgatgcct tcttgaagct cgcctttatt 2448541 aaaaccgacg caatcaagct gggacgactc gtttctgatc gtcattttga catgagtttt 2448601 atttgcccct atcttgcgga catcttccag tactgcattt tctacgagaa cgtgcggttt 2448661 cgggttcagc atgccaaaag gagacagcat gttcatttct gcgatgcttt caactgtaat 2448721 gtcttcgacg ccgcagacaa ggtcgacttc ctgtacggga ataaaatcct cttccgtaag 2448781 cgtattgtcc gctatttcat tcagcctgct tcgcaaatcc ggcacatctt cggctttcag 2448841 cgtcatcccc gcagccattg gatggccgcc gaaatgagga agaatatctc tgcattcaga 2448901 aaggctctca aataaattaa atcctctgat gcttcgggcc gaacctttag cgattccctt 2448961 ttcttcatca ataccaagaa caatggccgg tcggtagaaa cggtccacaa gctttgaagc 2449021 cacaatcccg acgactcccg ggttccatcc ggctttggcc acgacaattg cagtttgatc 2449081 gagcccttgc tgttcaacca tttcaatcgc ttcatccgtc attttgctga ccattttttg 2449141 gcgctctttg ttcagctggt caatttctgc ggcaagctct tccgcttcaa acgaatcctc 2449201 tgacataagc aaatgaacag cgggatccgc ctgttcgatt cttccgacgg cattcagcct 2449261 tggtgcgagc tgaaatccga ctgtttcttc gttcgcttct ccgatgtctc cgcctgacag 2449321 cttaatcagc tcttttaagc cgagccgatt tgtccgtcga agcctttcaa gtcctagtgt 2449381 tgctattaat ctgttttcgt catgcagcgg gactagatcg gcaatggtgc cgatagccgc 2449441 caggtcaagc agttcatcag gaagttcacc caataaagcg tgggcaagct taaacgcgac 2449501 tccaaccccg gcaagctctt taaacgggta agtgcagcca ggctgcttcg ggtggacgat 2449561 cgcacggaca tccggaagct ccggtcccgg ttcatgatga tcggtaatga tgacatccag 2449621 tccgagttcc tttgccacct tcgcttcatg cacagcggca attcctgtat caaccgtaat 2449681 gatcaaagag aagccccgtt ctttaatcga acgaaacgcc tgttcattag gtccatatcc 2449741 ttctttaaaa cggtcaggta tataaaaatc aacttgagcc gacagttttt gcagcgtgtg 2449801 aagcatcact gacgtacttg taaccccatc ggcgtcataa tcgccatata tcataatctt 2449861 ttcttgttgt gaaatcgcct gttttattcg atctgccgct tctttcatgc ctttcatttc 2449921 aaaaggatca taaaaatcgg catcctttgt atgtaaaaac agcctagcgc tttctgccgt 2449981 atcaaagcct ctttttacaa gcagggacgc aacaagaggt gttatatgca attgttctgt 2450041 gagtgatttg accttatcct gatctggtcg ctggatttcc catcgcattt ttgacgctaa 2450101 cataaattca cccctcaacc accctattat actagagcag gctgaggggt ttcaaataat 2450161 attcgaaaac tagtcttttt tctcaatcat ggctgatgca tcctgtgtgt cagtctgatc 2450221 agcaagatga gtatcctctt gtttatgtat tgctgttcta ttttctttcc gcaaggtttt 2450281 tatttcccgc ttcaatttca ttacctgaaa aatgccgaca gaaaatacga tcagtgctcc 2450341 cattaaaact gagcccaaaa taacaagaat gagcggccat tctgatcttc caaacaggta 2450401 atcaacttct acggatcgaa cattaatgac tgcgaaaata gcgacaatta aggtgaaaat 2450461 aagtgcgaaa ataatggtcc attgtttatt cattctcttt tcccccaaac ttcttattga 2450521 ggtaactttc ccaatcaaga ctggttttaa acatggctta acactaggtt aagctccctt 2450581 tgctgttaat ttttcccgga tcagcctctt cagtccggtt ccctcaccgg aaatcacaag 2450641 tgtatcgcct tcgtcaatga ctgtttcaga gctcggattc agttgtttat cctgattctt 2450701 tttaacaatt gcaatgaccg tcacatgata ttcctgaccc acattcaaat caccaatcgt 2450761 ctgatgaatg gcaggcgctc ccgcctctgc tttacaccac tctataatca aatcatcaag 2450821 ggctgactcg acctgttcta atgctttcgg tttatatgcc attccgccaa gaattgcaga 2450881 catttgcctt gcttcagcgt catcaaactg cacggaggca acacattcct catggtcgtt 2450941 ttcgtcaaaa tagtaaagct ctctccgtcc gtcatgatga atgataattg aaattttatc 2451001 acggtttcta gtaatcattt caactttttg tcctatgccc ggcagctctg attcgcgaac 2451061 cctcatatat aaaccctcct acatatctga aaaccagcca taaacacttt taacaccata 2451121 tatatgttta aatgtaagcg tatgtcatta tagcaaatgt ctattttaag ttcaatgaaa 2451181 cttcaaaaaa caggctgccc tgcagaggac agcctgatat tttttattgc gccgaatctt 2451241 ttttcagttc tcttcctttc catgcaagcc aaatttgtgc ggcaatgtat agagaagaat 2451301 aaacgcctgt taacagcccg accaataaag caattgagaa gttagtaata gaagatgctc 2451361 caaagatcag caatgtcaca acaacaatca caacggttaa tacagtgtta attgaacgtg 2451421 taaaggtttg ctgcaggctc aggtttacaa tatggttcag atcggcaaag gttttcggct 2451481 tacgcttttt catatgctcg cggaccctgt caaatgtaac gattgtatcg ttaatggaat 2451541 acccgattat cgtcaagatg gccgcgatga atgtaacatc tacctcaagc cttgtaatac 2451601 tgaagaacgt gacgataaag aatgcgtcat atagcaatga ggcgatggca gcaatcgcca 2451661 ttttgtattc gaatcggatt gaaacgtaaa taatgatgcc aatagaagct atagcaactg 2451721 cgtacagcgc atttctcgcc agctccttac cgactgtcgg tgaaactgtg ctgacatttg 2451781 gatcagatcc gtatttgtct ttaaaatacg tttttacttt tgcaatggtt tctttatctg 2451841 gcaccccgac aaaacgggca acaccgatat tgctcttttc gcctgacaga actacagtat 2451901 cagggtccat acccagagat tcaaaatcct tctcaacttg ctctgtcgtc agcttatggt 2451961 cgctttgcac ttcaatccgt gcaccgcttg caaagtcaat gccaagattc agcctgaaca 2452021 caagcaggat aataatcccg gcaaccgtga ccgcactgga gaaaataaag aagtatttgc 2452081 gtttgctcgt gaaatcccat ttttggaatg gcgtatgcgg ctctgtattt tcatccgtat 2452141 cctgaatatc catgatatgt ttcttattga caccaaacca gccttttttc cgatcaagcc 2452201 atctgctttc cacaaggaga gcgaggagaa atctcgataa gaaaacggca gtgataaagc 2452261 ttgtcaaaat cgataggatc agcattgtcg caaacccttt aacagagctt gtcccaaaga 2452321 taaagagcac aaccgctgca ataatggttg taatattcgc gtcaaaaatc gtcgcaaatg 2452381 accgtctgtt tcctgaacgg aaggcagagc ggactgactt tcctagcttg agctcttctt 2452441 taatccgctc ataggtaata atgttggcgt caacagccat cccgacacct aaaatgagag 2452501 cggcaattcc cggaagcgtg agtacggcat tcatccagtc aaagatctgg agtgtaatgt 2452561 agatataaac agacagcgta atcaccgcga ttaatcccgg cagacggtaa tagaaaagca 2452621 taaataagaa aataattgcg ataccgacaa taccggcaaa caccgtatca tggagagcct 2452681 gctggccgaa ttgcgcgcct actgatgtcg aatacttttc agtcagtttc acaggaagtg 2452741 cgcctgcgtt taaaatgctg gctaaatctt tcgcttcttg agctgtgaaa tgaccttcaa 2452801 tttttacatc agttgtattt agttcctgac ttacatttgg agcggataca aatttaggat 2452861 gctctttttg aacttctttc ttaaaggaat cacctttatc ataatccaac caaatgacaa 2452921 gctggttgtt tggcgccatt ttcatgacct tcttggtcac ttcaccaaat ttatcagcgt 2452981 ctttcagctt aatcgtgaca attggctcat ttgttgtgct atcataagtt tgtttagcgc 2453041 cgttttcgac tagatcagca ccgtttaaca gttccttatc atttgcatct ctgaaagaaa 2453101 gctgcgcttc agtcgccaaa atttcacgcg ctctgttttg gtttgtcacg ccagcgagct 2453161 gaacgcgaat ccggttattc ccttcaattt ggatgttcgg ttcgctgaca ccgagaacat 2453221 tggcccggcg gttcagtgcc tctactgtgc tgaccagaac gtcttttgtg attttgtcac 2453281 ctttttttac aggctgtaca tcatacagca cctcaaatcc gccttgcaaa tccaatccta 2453341 acgtaatatt gttagcggca ggcttcgtaa agtagcccaa gcccgtgccg atcaatagaa 2453401 cgaaaaggaa aaacgcaatc aagcgtcctt ttttcattat gtatatcctc ccttaaacct 2453461 gtgcgaatca acctgctatc tcagcagttc ttccaatgct tcctggccct cttcactgcc 2453521 cagccaatta gacgttttaa atgactcaac ggttgcatag ttcataaatt cgccaatttt 2453581 cactgataaa atatcactcg ccagttcata aatgctcagt tccgttttct ttttccactt 2453641 cttatctgtt aagtatgacc acaaactttc gagttcaaca tcatcatacc cgagaatctt 2453701 aaactcttcc agtttgctgt aaagaaacgg cctgacgtgg tctttatata gatcggctgg 2453761 atgcttctcc acgaattcca cgctcctttt ttattgtttt tcaagaagac ttgtcatgct 2453821 tggacgacat atacgcatat ctttattgta tatgattcca ggtagtttga gaaggcaggg 2453881 ggtaaaaatg gcgaaacaga cgtttttaaa gggcactctt atccttatcg cagcaggaat 2453941 ggttacaaga atgctcgggt ttgtcaaccg ggtggttatc gcccgtttta tcggtgaaga 2454001 aggagtcggg ctttacatga tggcagcgcc tactttcttc ttggccacta cattaactca 2454061 attcggtctg ccggtcgcga tcagcaagct agtcgctgaa gccagtgcgc gcggagatca 2454121 tcaaaaaacg aaaaatattt tagtcatgtc tctgaccatt acgggagtgc tcagcctcat 2454181 ctttacaccg ctgtttctgt ttttcgcccc tgttatggct gaaacgatgc tgacagataa 2454241 gcgaacactg tatccgctct tggccattac gcctgttgtg ccgattattg ctatatcgag 2454301 tgtgctgagg ggatactttc aaggaaaaca gaatatgaac ccgcttgcta tgtcacaagt 2454361 ccttgaacag gttgtccgca tttcactcgt ggctgtctgc acaacgattt ttctccctta 2454421 cggaattgaa tatgctgcag cgggggcaat gctatcctca gtggcagggg agctggcatc 2454481 acttctttat ttattcgttt gctttaagta taaaaagaca attaaaatca gaaagcattt 2454541 tttacagtca attaaaaacg gaaaacaaac ctttacccaa ttaatgagcg tgtcccttcc 2454601 aacaaccggg agccgcttta tcggaaacct ctcttggttt ttcgagccaa tcgtcgtcgc 2454661 tcaaagcctt gccatcgccg gtgtggcaac agttgccgca acaaagcaat acggggaact 2454721 aaccggcttt gccatgacgc tgctgactct gcccagcttt attacatatt ctttgtcgac 2454781 cgcgcttgtt cctgcgatca gtgaaggaat ggagcagaaa aaattgcagg tggtggaata 2454841 ccgcttagaa caggcgatgc gtctctgtct gctcagcgga ggcatttcag ttgttatttt 2454901 atttgtattt gcggatgagc tgatgagagt gatgtacggt tcctcaggcg cagctgtatt 2454961 tataaaagtg atggccccgt tttttctgct ttattatttc caaggcccgc ttcaagctgt 2455021 gctgcaggcg cttaatttgg caggagctgc gatgatgaac agcttaatcg gagcgcttgt 2455081 caaaacaggc cttatttttg tccttgccac aaggccttct cttggcatta tgggcgcggc 2455141 attagccatt gtgacaggca tggtgctcgt cacgctattg cacgcagcaa ccgtaagcaa 2455201 agtgctgccg atcagcatca aaatcaagga gtacgcgctc agcttcgctg ttattgtaat 2455261 ttgcggattc atcagctccg ccatcaaaca atatataagc tttggagcat ctgaggctgt 2455321 caatctagcc ggatggattg cggcgagcgc cgccatttat atgatcctcc tgctcgtttt 2455381 ccgtttaatt aaaaaagatg agcttcgccg cattcccatt atcggacggt tgatcatccg 2455441 ataatggtca cgtgcggtgc ccatcttttt catcaatata tatttctccg tctgtaaacg 2455501 agcaaaatga aatatctgaa gggtttgtgt atccgtgttt ttgcaaactt tcaagcagcc 2455561 attttctatc tttactgatt ctggacaggt tttctgtttg aatgaagccg tctataatga 2455621 gcggcatttc gagctgccga tgctctccgc tgttttcttt cttaacaata gtcagtttgc 2455681 ccgacggctc taaaatagca aatgatacgt cagctactct gtcgatgcta ttttctctga 2455741 gctgaaccat taaatcatca aaattataac gctgtgattt catggcttct tcgtcaattt 2455801 ttccatattt gataattatg gtcggcttac cgtcaagaag ctggcggact tttcggtttt 2455861 ttaaagaaaa gtatgccaaa gtcacttgaa tgatcattaa tacaagcatt ggcaaaatgg 2455921 tatgaaatag atgatcgtct acgttttcta tggctaaaac ggcaatttca gccatcatga 2455981 taaagacaac gagatctaaa atactaagct ctccgatctc ccgtttgccc atgaaacgaa 2456041 aaatgaccaa tatcacaaaa tacaatacga ctgtgcgaaa cgcaatagtg agaagctctt 2456101 ccattatgca cctccaactc attataggtt gcaacaaaat gatcaattta tgtaagaaaa 2456161 accgattgca tttcacaaag cttttacgtc taattcatgg gataagggaa tacattttta 2456221 caaagacgag ccatcagcat gtctgacggt tttgaacaaa aagaacagaa gccttttaat 2456281 acaggcagag aggagacaat catggaggaa acgaaacaag ttggaaaagg cattctttac 2456341 ggcttaatcg ccatattttc agccatgctc ctgacaagtt tagcggtttc acttttattg 2456401 accgcaacct cgctggaaga atcatcattt aactggctga tcaccgctat ctcatttctc 2456461 tctttattta tcggcgggtt catttcaggc gggaaaggca aggaaagagg ctggatgatt 2456521 ggcgcattga ccgccttaag tttttctctg attatcttat tgtttcagta tttaggattc 2456581 ggaaagacat ttacagcaga acagctgatc ttccatctgg gatttttagg ggtgtgcatg 2456641 ctgggcggga ttttcggcgt gaacatgagg ggaaacaggt cttccacata aaaaagagcg 2456701 ggctcacttg cccgctcttt tttgtttgct atgtatagct cctgctgtta ttcagcagca 2456761 gaaacttctc tgatcgcgcg gcggtcgaac gtaagacgtg tgttatcacc agtcttaatt 2456821 acgactttgc tttcgtcgat agagtcaaca gtaccgtgca atcccccgat tgtcactact 2456881 gaatcgcctt ttttcagttc ctcttgcatt tggcgtacag ccttttgctg cttttgctga 2456941 ggacgaatca gcaagaagta aaggaccgca aacattaaaa taataggaac caatgtacct 2457001 aaagtgccag tcatcatttt cacccctttc tgtaagcctg ttatgtttat ttagaagctt 2457061 ttcgcatttg gcttgttata gccgtaacgc tcaaagaact cttctctgaa atcacccaga 2457121 cgatcctcgc gaatagcctg tcttacctgc tccattaagt gtaacagaaa atgaaggtta 2457181 tggtaagttg ttaatcgaag gccgaatgtt tcattgcagc gaatcaagtg cctaatgtac 2457241 gcgcgagtgt agtttttaca tgtatagcaa tcacactctt catcaatcgg acggaagtct 2457301 ctttcaaatt tcgcattttt catattgagt cgtccttcag cagtaaacac tgtgccgttt 2457361 cttgcaatcc gtgtaggcag cacacagtca aacatatcga ccccgcggat cgctccgtcg 2457421 atcagtgcgt ccggagaacc tactcccatc agatatctcg gtttatcctt cggcaagagc 2457481 ggtgttgtga attcgagtac acggttcatg acatccttcg gttcacctac agacaatccg 2457541 cctatagcat atcccggaaa atcaagcgaa atcaagtcct tcgcactttg tgtccgcaga 2457601 tcttcatatt ctccgccttg tacaatacca aacagccctt gttcatcctg acgattgtgg 2457661 gcattcaggc agcgttccgc ccagcggctt gtccgttcaa ctgacctctt catgtagtcg 2457721 tactccgccg ggtatggcgg gcattcgtca aacgccatca taatatcaga gccgagtgcg 2457781 ttttggatct ccatcgcttt ttccggagat aaaaacagct tgtctccatt tagatgattg 2457841 cggaaatgga caccctcttc ctctatatta cgaaacttgc ttaaagaaaa gacctgaaaa 2457901 ccgcctgaat ctgttaaaat tgcgcggtcc cagttcataa atttatggag cccgcccgct 2457961 tctttgacaa tgtcttggcc cggacgaagc catagatgat aagtgttgct caaaatgatg 2458021 cctgcatcca ttgctttcag ctcttcaggc gacattgttt tgactgtcgc cagtgtgccg 2458081 accggcataa aaaccggcgt ttcgaaggag ccgtgaggcg tatgcacttt gcccagccgc 2458141 gctcctgttt gtttgcattc ttttataaat tcatagcgta ttggttgttc agccactttt 2458201 gatgaggcct cctgttctca aattatataa tcagcatcgc gtctccgaag ctgaagaaac 2458261 ggtattcctc ttccactgca tggttatagg cacgcagaat gttttctctt ccagcaagcg 2458321 cgctgaccag cataatcaat gacgatttcg gcaaatggaa gtttgtaatc attccgtcaa 2458381 tggctttaaa ttcatagccc ggataaataa aaatagatgt ccagccgctt gatgctttaa 2458441 attgcccgtc atgttctccg gcaatcgtct caagcgtgcg tgtcgaggtc gtgccgacag 2458501 aaatgatccg accgccattt tctcttactt tgtttaaggc tgcagccgtt tcttctgaca 2458561 tttgataaaa ctctgcatgc atattatgct cttccacttc atcggcactc acagggcgaa 2458621 acgttccaag gcctacgtgc agtgtgatga actcaatttg cacgcctttg tctttcagct 2458681 gctgtaagat ttcttccgtg aagtgaaggc cagctgtagg cgcagcagca gagccaattt 2458741 cttttgaata cactgtctgg tagcgctctt tgtcatcaag ctgttctttg atatatggag 2458801 ggagcggcat ctctccaagg gattcaagca cctcgtagaa aataccgtca tattgaaatt 2458861 ccatctttct gccgccgtgc tcaagctctt ccgtgcagat tgccttcaat cttccgtctc 2458921 caaatgtgac aacagttcct tttttcaccc gtttcgccgg tttggcaagt gtttcccatt 2458981 tatcaccggt ttcctgtttc aacaaaagaa gttccacttt cgcgccggta tcctcttttg 2459041 tgccgaataa ccgcgcaggc agtacccggg tattgttcag gactagacaa tcgccttcgt 2459101 taaagaagct gataatgtgt ttaaacgagc tgtcagtaag ctctcctgta tgtttatcga 2459161 gcaccatcag ccttgaagca tcacgctgct ccaacggtac ttgtgcaatt aaacgttctg 2459221 gtagttcaaa atcaaataaa tcgactttca tgatgatttc acctttattc tagtcttttg 2459281 ttatttcatt ctgccaaaaa gattaagcaa aattgataat accacactta taataataca 2459341 agtgacaacc gggaagaaaa acgtaacatt tccttttttt acaaaaatat ctcccggcat 2459401 cttgccgaca aaatgcaaaa ctgctccgat aataagcaaa acagcaccaa gaatcataat 2459461 gatcttagga aattcagtca tatcggggag cctccatttg gaaatgatga taaacggccg 2459521 gtgtcacgat ccttccacgc ggcgttcttt gtataaatcc aatttgcagc agatatggtt 2459581 catatacgtc ttcaatcgta tgcgattcct cgccgatggt agctgaaatc gtatcaaggc 2459641 ctactgggcc gccgttgaat ttttcgatca tgcccatcag cagcttatga tcaatatgat 2459701 ccaaaccgag gcggtcaacc tgaagccgct ccagcgcatt ctgagaaatg tcttccgtaa 2459761 tcctgctgtc acccagcact tgggcgaaat cgcgcaccct tctcagcagg cggttcgcca 2459821 cgcggggcgt ccctctcgat cttcttgcaa tttcaagagc cgacggttta tcaatctcaa 2459881 cctcgaatac atcagcggtt cttgtgacaa tatccgccag ttcttcttgt gtatagtact 2459941 caaggcgaga cattacgccg aatctgtctc ttaaaggagc cgtcaaaagc cccaccctcg 2460001 tcgtggctcc caccagcgta aaaggcggaa ggtcgaggcg aaccgagcgg gcagatgggc 2460061 ctttgccaat cacaatgtcc aggcaaaagt cttccattgc aggataaagc acctcttcga 2460121 tcgatctgtg cagcctatgt atttcatcaa taaataatac atctcccggt tccagcgccg 2460181 ttaatatagc agccaaatca ccaggccttt caatcgcagg ccctgatgtc gtccgcaatt 2460241 ccactcccat ttcattagca acaatcgaag caagcgttgt ttttccgagt ccgggcggcc 2460301 cgtacagaag aacatgatcc agcgtctcct gtctcatttt cgccgcatct ataaacacgc 2460361 gcaaattttc ttttacctta tgctgcccga tatactgtgc cagattttgc ggcctcaggc 2460421 tttgctctat cactgattca tggttgtctg cttcacttga gacgagccgt tcatccatga 2460481 acatcacctt actttaatag tttttgtaat gcttttttca catattggtc tgttgtcagc 2460541 ccaatttctt ctttaaggtg aggaagcacc tttttgattt ctttttcagc atatccgaga 2460601 accctgaggg cttcaagtgc ttcttcaaga gccgtttccg ctgtttgctt ttcaagcctt 2460661 tcttcatgat taaacagatt ttcaatcatt tcaggcacaa catctgccag ctttcctttt 2460721 aaatctagaa taatctggcg tgcggttttc tttcctactc caggaaactt gaccaaaaaa 2460781 gcttcatctt cattttcaat tgcttggatg accgctccgg gatcacccga gcccaagatg 2460841 gcaagtgctc ctttcgggcc aattccggtc acgtttaaca gctttgtaaa gagcgccttc 2460901 tcctctcttg ttgaaaaacc ataaagcgaa aaagcatcct ctctgatatg atggtatgta 2460961 aaaatcgttt cttggcttct ctccttatat ataaacggat tcggcgtgaa aatctgatag 2461021 ccgatgccgc cgttctctat gacaatatat tggggagata cataatcaat cgtcccttta 2461081 acaaattcaa tcacgcaaat tcacctcttt gactgttctt cattgtacca taaaaacagc 2461141 caaagtctta tagaaaagtt aacatatgtt cgcttctctc tcattctttc acgaaaaaaa 2461201 agacatgaat acatgtcttc aatcagcgga cgctacccgc tgtatgtctt catatgttcg 2461261 atgacatcct caaactccgc ttttgtccga aatggaatgc ctttcagcag atttttttgc 2461321 atatggcttt ccagcctttc taaatcaatt tgaaaaaaag actgaattgg ttcggaagct 2461381 ggctcaggcc gcccatgaaa agtggaaatc actccattat ccgatacacc gatatacccg 2461441 ttgaccttgc tgagcggaga aatatcgtcc atttgcttcc ggaagagcac atatcccttt 2461501 ttttgttcca ctagcgtcca tccggcataa gctgcccaaa aatcatccat agaaaacact 2461561 ttttcatgct tatgctcaat gctgacatcg ccgtccaaat acaccttttc aagctgcaca 2461621 tgcacctgca gcggctcata gtgctccact tccgcgccaa gtgcgcggga aggagctcct 2461681 attaaaaata ctgccgctga gcaaagaatg cccagcaaaa gatacgccgt gctgaatcgt 2461741 ttcaccctct acacctcttt gcacacgttt atgattagtt tgaccaaaga ggctactgct 2461801 taaccgtttt atcaaaattt gtctgcacat tttccctgac aaaccgttcc tccgtataca 2461861 catctgtgct ttgctcagaa attgtcaaga atcgcgtcag aaaggcactg aaaaaataca 2461921 atgccgcaaa gatccaaatc acgccacctg caccgagcgg cccaatgaaa agactcacga 2461981 tgcccggcgc gataaacgca cataaaccag atcccaaatt caacactgac atggcagcac 2462041 ctttattatc aggtgcaagc gtcggcaaaa gcgcgcttaa tgggacgtac cctgctaaag 2462101 ccgcgccgta gcagcaggcg ataatcatga gcacccaata ctgatgcccg atcagctgag 2462161 gcgtgtaata cagcgccagc gtaaaaatac cgcatccgac accgccaaac cacatgaccg 2462221 tattgcgcca gcctagttta tctccgactg caccgaaaat gatattaaac acaatattca 2462281 caaaaaacag cgtcccccat atttgcagcc attccgaaac cgaatacccg tatcgtgcta 2462341 aataagtagg aagaaagatg gcaaatccaa attgtcctat cgcattaatc gtcttgacca 2462401 ctccgccgat gcctacctta gggttttcaa acataatcgt aaatgccttc gacagttctt 2462461 tccatttcgg ctgatcttgt ttttgtatcg gagtaaattt atctttgtta aaaaataagg 2462521 caagaattcc gcctgccgcc acaaacagta aagcgctcca aagcgtattg atttctccaa 2462581 aggccggaac tgcatagctg gaatagaacg gaccgagcac gttaaggccg cacgtaaaca 2462641 taaaccaaaa ccagccgacg gcttttccaa gaatattttg agaggtgctg tatgacaccc 2462701 atacgagaaa agagtatgca aacagcggat atcccaagcc tctaagagca tagctgccca 2462761 agagagccgg ataatacata tgaggaatcg cccagccgat aaaagcggcc gaaccgagga 2462821 taaatgcaag caatccgaca gtcatcgttt ttctcggccc ccaagtttgg acaaacgttc 2462881 ctgaaagcca agctgagatg gtgacagcaa tgccgtacat ggtaaataac gatgcggatt 2462941 gctgcatact gagaccatga tcaacgagaa aaggagacag ccagccttgt tcgaggccgt 2463001 ctccaaccat aaagatgaca acgccaatat aaccccaaac catgtgagaa ggaattccga 2463061 ttttgttcaa aacatttcct ttagcatgta ctgtattcat tttctccacc gcctacttaa 2463121 agtatcaatg gagtatatac ccaagcttgc tgaattgtaa tcctgttaga ttaaaaagcg 2463181 attttttcag tgtgctcaat gctaacaggc atgccaaaag caagcgattg ctgtgctgct 2463241 ctggcgatcc tcccggcctg taaaccgtca ttgccggtgc agggagtctc ctggtttgtg 2463301 ccgatcgctt ctgcaaaacg gagaatctcc tcctcatatg aatccttata gcgttcaagg 2463361 aaaaagaaat gcggtttatc cttcatcaca aaatcagctg ttgacacctc aaccgttgtc 2463421 ggcctgctat tgtcagccgc tgcagagcct ttcgtcccga aaacctcaac ccgctggtca 2463481 tatccgtaca cagcttggcg gctgttatca atcacagcca tggcaccgtt ttcaaaagtc 2463541 agtgtaataa cagctgtatc aatatcaccc agctccgcaa aagaaggatt caccaaagcc 2463601 gcccctttgg catacacttc cgtcacttcg cttcccataa tatatctggc catatcaaaa 2463661 tcatggatcg acatatccat aaacaatccg cctgacgtac ggacataatc tatattcggg 2463721 ggttctgggt cccgggacgt gatttttaat aaatgaggtg taccgatttc accattttca 2463781 acaatcgttt tgattttctt aaaatgagga tcaaagcggc ggttaaatcc gacttgaagt 2463841 gttaccccgt gtttccggac agccgcaagc gcttcactcg tttcgtccag agagaaacta 2463901 acgggcttct cacaaaatat atgctttttc gcctcggctg cttctttgat catctgtgca 2463961 tgtacggctg taggagagca aataaaaata gcatcaatat caggatcatg taataaatca 2464021 cgataatcag aggttatgta ttcaatctga tgactgtcgg cccagctttt tatacggctc 2464081 gcctgaatgt cagagattgc ttttattttc atgtgaggaa tccggcttat attttgaaca 2464141 tgaagtttgc cgatgcggcc tgcaccgata atccctgtca caatctgttt tgtcatggct 2464201 tcttccccct tgatcattca cgaaagcgct ttatttaaaa ttaatactat cccatttgta 2464261 agcgcttttc aagaatggaa attaaacgtt ctatgtctct tttatcacaa ttcatgctta 2464321 taagtagcct tcttcttcaa gaccagatac actagaatta ggctcttttt cctgaacagt 2464381 ttatgatttt cctataaaca gctgcataaa atagagcaaa gaaggtgaat gaaatgctga 2464441 caaaagcaga ggcactggcc cataccgtca tataccgcaa gaacagcaga tttgataaag 2464501 tcaaagagaa atccgaggaa ttaacactaa tcggcaaggg aagaagcgcc tatgtgtttg 2464561 ccttaacaga aggcggtcga aaaatggcgc tgaaagtatt ttttccggaa tatcaagcga 2464621 cagcagtcaa agaagcagcg atctatgaaa aattagccgg gtccgcattc tatcctgaca 2464681 tttacgaaac tggcgattca tttattctca tggaatatat taaaggtgaa accttttata 2464741 actgtctgaa gaaaggcatt gcaatcagtg atgacatgat tcagcaggtt gaagaagcgc 2464801 tttctgacgc ccgggcagcc ggactgaacc cgtcagatat tcatttgcgg aatctgatat 2464861 tgacagaaac cggggcggtg cgggtgattg atgttgcgag atttgagcag acaaaaacat 2464921 gcacgcagtg ggacgactta aaatccgcat atcatgcact ctacaaaaaa ccgatattcc 2464981 ccaaaaagat tccgggtttt tggctggaga tcatcgcatt tttatataag aaagattggt 2465041 ttcaaaagca tttcgcacag cggaaaagaa aatattctta aatcaaaaag gcagccgcac 2465101 aagcggctgc ctttatcatg tattttttac tttctgacgg cagaaatcag tttcatttgt 2465161 tcaggcgaca gcttaattcg atagcctctc acagttaagt agaccgcttc tgggtccttc 2465221 tcgccggaat gacaatacgt tttttccatt tctgtctccc ctcacccttt attggcttta 2465281 tttcatctta tcattgcttt attgaggtaa ttttaaagaa atgtaaagat tatatgaatc 2465341 cgatatatag taaaatgaga gaaaaaaagg gagagagtca cattaagacc gaaaacacct 2465401 tgagcttaga tgcagccaga ggtgaacttg taaatgaaaa aacacttgtc aagagaacaa 2465461 tctactggaa ttacccggac agccgcccag cagtgacgtg gatcaatcac aatacagtga 2465521 aaatcggcaa tcagacttta catcttgata ctgatgaaac gtatgattgg cgaaaagatg 2465581 atcattggat ccgtgaagaa ccgccgcagg cgtcagtgag gtgatgaaac atgaataaga 2465641 tgaacggaac aaatgatgaa aagcatttca atcattttgt gattgcttta tcctttatat 2465701 acggtttgac tgaactaggc tatttgttgc tgaaggattt tataacaatt gccataagtt 2465761 tgcctctgta gaaaaacgca gcgtagtcga tacgccgcgt tttttctttt tcccttcctc 2465821 ttcttattga taattacagg tcatataatg tgacaaatcg attgtagaaa tagttcgatt 2465881 agaccaaaat cctttttata catgtattcg aatttgaagt gagggggaag cttgatggca 2465941 gattttgttg ctagtttgaa tgcggtctta tggagtacgc ccgtcattta tattttattg 2466001 ggaattggat tcgccttttc aattatgacc cgttttttac aagtccgaca tttaaaagaa 2466061 atgattgttc agatgttcaa aggcaagagc tctgaagccg gcgtttcatc tttccaagcg 2466121 ttatcgattg cgctgtccgg ccgtgtgggc acaggaaaca tcgcgggagt ggcgacagca 2466181 attgcattcg gcggacccgg tgcagtgttc tggatgtggg cgattgcctt tatcggggcg 2466241 gcgagtgcct ttgtagaatc aacgcttgct caaatttaca aagtgaaaca agacggtcaa 2466301 tatcggggcg gccctgctta ttatatagaa aaaggcttag gcattaagtg gtttgccgtc 2466361 ttatttgccg ctgctgccct tattgcaatg gcctttctaa tgccgggcgt acagtccaac 2466421 tccattgcgg ctgggatcca aaatgcattc ggcatctctc ctttcgtcac agggtgcggt 2466481 ctggttttat tattagggtt cattattttt ggcggcgtca aacgaattgc caatgcggcg 2466541 caaatgattg ttccatttat ggccattgga tatatcctgc tgtctttgat tattattgtc 2466601 atgaatgtgt ctgaattgcc tgctgtgatc tcattaatat tcaaaagcgc cttcgcattg 2466661 gattccgctt ttggcggctt gatcggtatg gcgatttcct ggggcgttaa acgtggcatt 2466721 tactcaaacg aagccggcca gggaacaggc ccgcatccgg cagctgctgc agaggtttct 2466781 catccggtca agcagggact ggttcaggca ttttctgttt atattgacac cttgtttgta 2466841 tgttccgcta cagctttcat gatcttgttt accggcatgt acaataccca ggctgcagat 2466901 ggttccttta tcgttcacca gcttaaaggc gtagaagcag gacctggttt cacacaagcg 2466961 gcaattgaca gtgttcttcc cggattcggt gcaggctttg ttgccatcgc tttattcttc 2467021 ttcgctttta caacaattat ggcgtattac tacatcgcag aaacaaatat cgcctattta 2467081 gcacgaggca gagaaagcaa atgggcgatg cttggcttaa aactgattat tttagccgcc 2467141 acgttctatg gtactgtgaa aacagcttca cttgcttggg cattagggga tgcagggctt 2467201 ggcattatgg tatggctgaa cgtcattgcc attgtgctgc ttgccaagcc ggcgctcctt 2467261 gctttaaagg attatgagcg ccaaaagaag cagggcttag acccgatctt tgatccaaaa 2467321 gcgctgggta tcaaaaacgc tgatttctgg gagaaagaat acactcatga aagtgaacgt 2467381 gtctcctgaa catactaaaa ccggcccgat atgacctcgt gccggttttt tatgaacgat 2467441 agtttgtata cacttcttga acatcatcgt catcttcaag gacgtctatt aatgtttcca 2467501 gcttctcaac agcctgatca tcggcttctg cataggtatt gggaagcatg gtcacctccg 2467561 ccgaagaaat tagatatttc gattcgaggg ctgttttcac ctcttcaaaa tgctcaggct 2467621 ctgtgaaaac ctcatatagg tcttcttcaa ttcgcagctc ttctcctcct gcttcaagca 2467681 catcaagcat gagctcatct tcttctattt gccgttcagt acggtctatc gtaatgaacc 2467741 cctttcgttc aaataaaaag gctacacatc cgctttctcc cagacttccg ccatttttat 2467801 taaaggctgt ccgcacattt gacgccgttc ggtttttatt atctgttacg cattcaacca 2467861 tgacggcaat ccctgaaggg ccgtagcctt cataggtgat ttcttcatag ctgcttccgt 2467921 cttggcctcc cgcagctttt ttaatggccc gatctatatt ttcattcggc atattggcgc 2467981 cttttgcttt ttcgatgaca agacgcaatg ctgaatttgc ttctggatcc gctccgcctt 2468041 ctttcgctgc cacatagatt tcttttgcca gcttcataaa tattttcccg cgctttgcat 2468101 cctgtgcatt ttttcttttt tgaatgtttt tccacttgga atggcctgcc atgttttcac 2468161 cttcttttac attttctatg tacactttaa tgggaaatgt tcgctgatgc aaagaaaaag 2468221 gctgccgaat atcacttccg gcagcccttc cttcctagcg gttgttcatt ttatgaagtt 2468281 ttctgaacag ccctttatct gttgatactt ggacgtcacg gccatttgca tagttgcgcg 2468341 ctgcttttac aacattatct ctgtcagact ttgtgaactc tctgtggctt ttgactgcga 2468401 taactactcg gtcatccgat accataactt gtgtgtcatt gacgtttttc acttgtttca 2468461 cacggttggc aatttttgca gccagtcttc tgttttcttg gttgtcatac ccgttgttcg 2468521 ctgcattccg attcatgttt cggttattcg tgttgttata tgttccgtca gttgccaaag 2468581 gaacacgatc gtcagcagta acacggtcac ggttatttac attcgtggtg tttcggttac 2468641 cgtcgttctg atcctccatt aattcagaaa caggaccatc gtggtcgatt ccgtctccct 2468701 gtctatcggc gtcattttca tttgtataat atccgattgg acgggtattg ccgttattgc 2468761 gcgtatcatt catagcatta tcgtttgctc cgcatgctgt taagccggct gtcattagaa 2468821 tcaggctagc gatcgtcatt tttttaccca atggaaaaac cccccgtgga cgaattgagc 2468881 atgtttgctc gcttttatca tgtgcgtatg gggggcatgt taagcgtgtc agttctctcc 2468941 atttggcagt gatctgcttg aaaacaaaaa aaggaacgat ttacatcgtt ccgaacgatc 2469001 actcattttc ttcttccgga cggccaaaca tttggtttac agaaggctgg ttcgtcattg 2469061 gcatagaaac tcctgccgaa tatgggtttg gatttgggtt agctgtgcca tatggcatat 2469121 tagggcttcc ataagctccc attcccgaat ggccaggtgc agagaaatat ggctgatgat 2469181 caccgtcaca gccgcagtcg tcatgatctt tgtatggcat gtaaccatga gccgcagcag 2469241 gctggtatgc tcccattact tggggagtgc cgtaataagg gccatacggc atatgtccat 2469301 acggagatcc ataagccgga gatgcgtatt gcggcgcacc gtatgaaccg taatgtccgt 2469361 gatggctgtt ttcatgatgc tggttttcat aacccgggtc atactgaggc gatacaaagc 2469421 ctggctggta tccatgcatc ggatgcattg gataagcttg tgccggatag tacggatagc 2469481 ataatcctga tcctggaaga attggcgaaa caggcaccgg acacggtacg aaatgagccg 2469541 gataatgata ataaggctga acagccggca tcggcatatt cggaactgtg tgatgaacgt 2469601 tttcctcttc tataccgcct acctctggcg cctttggcat attaggcata ttcggataat 2469661 ttgcattttc catattactc atagcctcct gttgtggaaa ttggtcttgc atatgataca 2469721 tatgatccat atttccgtca tgatgttttt tcggctcctc cggtttagga ggcgaccaag 2469781 gctggaaaag ctgtttcata tcataataat cgttcacatc agcttcaggg tacacatttt 2469841 cctgcaaatt aggcatcggc gggacatacg gcatggactt cttttctttc ggctttgtgt 2469901 cttctacatc gacaacggat ttaggcttct ctttcgcata tggatgttct tgcttcacac 2469961 tcccggccgc aggacttttg cccgcttttg gctcttttct gaccgggact ccttctgacg 2470021 gcacttttat tttcattcca ggcatgatta agtctggatt gctaagctgt gtattgagtt 2470081 ttttcacttc ctcaacatcg actccgtact tttcagctat tttccagagc gaatcgcctt 2470141 tttgaacgat atggattttc aacgttttcc cctcctatgc aaaacgtgaa cagttcagct 2470201 gtgattacaa tatgtttctt cacaacatat gcctgaacaa aagaagttat gagtaaagga 2470261 agggaaaata tttctgatct acgtgatcga aagcattcga ttcagggcaa ggagtgcatc 2470321 ttcctgaatg gcttttggca ccttgatgac gcctgaaggt tctccttttt caatttgttc 2470381 cagcgaccac aacaaatgcg gcaaatcaat tcggttcatt gtcaggcaag ggcacatgtc 2470441 agggttgagt gattcgattt gtttatctgg atgctcgtga atgatccgct gaacaagatt 2470501 catttctgtc ccgattgccc acttgcttcc cgccggagcc tggttgattg tgtcgataat 2470561 atatttcgtt gatccgttat catcgcttag tgtcacgact tcgtgtgaac attccgggtg 2470621 cacaatgatc tgaatgtcgg ggtctcgctc tctcatatca tggatatttt tagtggtgaa 2470681 tttctcgtga acagagcaat gccctttcca caaaatcact ttcacattcg tatgcccgga 2470741 ttcagctact aattcatctt tcatcggatc ccacacagcc atatcttcaa gcgcaatgcc 2470801 cagatcataa gccgtatttc tccctaaatg ctgatcaggc aaaaataaaa ttcttttttt 2470861 ctgtgtaaac gcccattcaa gcactttttt cgcattcgaa gaagttacag ttgctccgcc 2470921 atgctttccg acgaatgcct tgatctccgc agtggagttc acataagtta aaggtatgat 2470981 cgtatctcca aatatatgct gaagcttctt ccatgcccta ttggtctgct gcatgtcagc 2471041 catgtcagcc atagaacatc cagctctcat atctggcagg acgaccgttt gctgctcgct 2471101 tgtcagcata tcggcggttt ctgccataaa gtgaacgccg caaaatacga tataatccgc 2471161 ttctttgttt ttttccgcta cttgggccaa ttgcagggag tcgcctgttt ggtcagcaaa 2471221 ttgtatcact tcatcctttt gataatgatg gcctggtata aagagcctgc tgccgaactt 2471281 tttcttaatg gcggcaacgc gcgtttccat atcctttctc gatagttctt tataactttc 2471341 gggcatcata tcattcgatt gtttgatcac atcaagaatt gacataacag cattcctcca 2471401 cagattcatt tgataacgta acatccatgc tgatatctaa acttttgacg gaatgagtca 2471461 gaaatcctaa tgaaatataa ttcacacccg tccctttaaa agcaggcaaa gattctaacg 2471521 taatcccgcc agaggcttca gtttttatat tagccggtgt gagctttgca aaatgacgga 2471581 ccgtatcagg cggacagttg tcaaacataa taacatccgc tccagctgca attgcttccc 2471641 gcagctgttc ctccgtttca atttccacct cgatatttac catgtgccct gcggcctgac 2471701 gggctttttt gcacgcctct aaaatagagc cgcatgctgc gatatgatta tctttaatca 2471761 tgatgccgtc atacaaaccg aatcgatgat tatacccgcc gccggctctg acagcatatt 2471821 tctccagcat tctgagcccc ggtgttgttt ttctcgtgtc acaaatttta atctgttcat 2471881 catccagaca ccgaacagcc tctcttgtca ttgtcgcaat tcctgacagc ctctgaataa 2471941 gatttaatac gacccgctct cctgaaagga gcgcagctgc gggaccgtgt aactcggcaa 2472001 tcacttcacc tttatgcaac atgtccccat cttttttgtg taaaatgctt tgaacatttt 2472061 cgtccaataa cgaaaagcct tcttttatga tcgctgctcc tgcaaaaata ccctctgact 2472121 ttgcaacaat ctccgcttca cagctctgtt ctccaaaaat agactgcgat gtaagatccc 2472181 ctgtcccaat atcctcaaga aaaaagtgat tcagtaattt tttcagctgt aaatgattca 2472241 ttgttccaaa tcccctcgtt ttttctgatc ttcgttcctt tttttgtatg gacaatttgt 2472301 cttccttgcc agctcacctc agcatgagga aaatcggtgc ggaagtgagc ccctctgctt 2472361 tcctcccgca aaagcgcaga aaacgtcatc agctttgcag tttgccatag atgagaaagt 2472421 tccatctgcc gaattgtgat atccttcaca tttacttcct gaaaaggcag cgtatgaagc 2472481 cagatgctaa gctcaatcaa actgctttgt tcccgcagaa tagacatgtg gcttgtcatt 2472541 ttgctttgca gttcatgccc ctctatatcc ggcacctcgt agaagacact ggtttctagc 2472601 cctgattgat attgcctgtt ataaaccggt ttttggataa tatgctctgc tgcccttttt 2472661 ccaaatacca gcgcttccaa taaagaattg cttgcaagcc ggtttgctcc atgtaaaccg 2472721 gagcatgctg tctcgccaat cgcataaagc cccggcactg tcgtttctcc ccagcgatta 2472781 actgaaacac ctcccattaa gaaatgcatt cccggagcaa caggaatttt tccgctgtgg 2472841 atatcaatcc ctgctttttc acaaatagcg gtgatggtag ggaaacgcgt ttcaaaatca 2472901 gaaatcgcac tgaagtctat ataaacgcga tttccttttg ccatttcttc gtgaataacc 2472961 cgtgagacaa tatctcttgg agccaggtca cctaaaggat gccgttcagc cataatcctg 2473021 cggccgtttt cgtctactaa acatccgcct tcccctctga cagcttctga aacaagcccg 2473081 taggaaacac catttttcac aagcagtgtc gggtgaaact gagtaaactc caaatccgtt 2473141 aattccgccc cggcccggta agccagagaa agaccgtcac ctgtgacagt gagatcattc 2473201 gtatggtgaa gaaacaggtt tccacagccg ccggcagcca gcacaacttc gtctgcgtgc 2473261 cttaccttga gccgcccttt gctgtctttt gtcatgacgc cgatacatcg tccgtcctct 2473321 ataagcaaat ctgctgccgt ttcattctcg attaacttga ttttgctgtt gatccgtttg 2473381 agcaaataat cgataagcag cctgcctgtt gcgtctccgc ctgcatgaaa tatgcggttg 2473441 tatgagtggg ccccttctct tccaagacaa acaccgcctc gttcattgcg gtcgaatgga 2473501 aatccacgct ccaataggct ttgaaccatc atttttccat catgtaatac gtctgctaca 2473561 atagctagat tattatggcc gcaccctgcg tataacgtat cctccagatg ggcttcaatc 2473621 gagtcatctt ttgcataggc cgcagcaatc ccgccttgtg catagacaga attgctgttt 2473681 ttgacgcttt tttttgtgat aacagtcact tcgtatgagg gcgggaaagc tgcagctaag 2473741 gaaagtgccg ccgcccctga accgatgact gcaatcgtct ttttagacat atgccatcct 2473801 cctgttgttt acacctgtct tgacacctat atttacacaa ggataaaata aactcaagag 2473861 ttttttatgg agaacggatg gaggaagacc ggatgattta tttagattat gcagcgacaa 2473921 cgcctatttg tgaggaagcc cttactgtat atcagaagct tagtatggat atgtacggaa 2473981 atgccagcag cctgcatgat gcaggaggaa aagcaaagca catactggag tactgccgtg 2474041 aaaaaatcgc caacatcatt ggcggagaag caagcggcat ctattttaca agcggcggca 2474101 ctgaatccaa ttttctggcc attcaatcat tgttaaacgg cctgccaaaa acgaaaagac 2474161 attttattac gactgccatg gagcatcagt ccattcataa ttgcgctgct tttttggaac 2474221 agcagggata tgatgtaaca gtcattgaac cgaatgaata cgggcttatt accgaggaaa 2474281 tattactaac ccatatccgg ccggaaacag gccttgtatc tattcagcat gcaaattctg 2474341 aaaccgggat cattcagccc attcaacacc tgtcttcata cctgcacaat aaggggattc 2474401 ttcttcattg cgacgctgtt caaacgtttg gaaagatccc gatcaataca aaaaatctgg 2474461 gagtagatgc actctcaatg tccagccata aaatccacgg tcctaaagga gtaggggcgg 2474521 tctatatccg gccggatgtc ccttggaaac ccgtttatcc tctgactact cacgaatacg 2474581 gattcagagc cggcaccgta aatgttcccg ggatcggtgc cttcactgcc gctgcagaat 2474641 tgatcgtaag cgaaatggaa aaacagatat cccgcaatga ggcattaaga acatactttc 2474701 tagaccaaat ccgtattcgg tctctccctg taacccttgc agcagacact tcgaaagcag 2474761 aatgtcttcc gcatattata gggtgttttt ttcactcatt tgaaggacaa tatgttatgt 2474821 tagaatgtaa tcggagtaat atttgcattt caaccggcag cgcttgttct gcaggttacc 2474881 acggtccgtc tgaaacaatg aaagcattaa gaaaaaccga acaagaagct ctgcaattta 2474941 tccgcatctc ttttggcagg catacaacag ctgaacagct ggaacagtta ttacatacgt 2475001 ttacagtgct ttgggaacaa aagaaaggag aatttgatat tgaccgaaga attaaagcta 2475061 atgggcgcca acaggcgtga ccagcttctt ctgtggctga aggaatctaa atcaccgctg 2475121 acaggaggag aactcgcaaa aaaagcgaac gtctcaagac aggttattgt acaggatata 2475181 tcgctcttga aagcgaaaaa tgtaccgatt atcgccacaa gccaaggata tgtatacatg 2475241 gatgcagccg ctcagcagca ccagcaggca gaaagaatca tagcatgtct gcacggtcct 2475301 gaacggacag aagaggaact gcagctcatc gtcgacgaag gcgttacagt aaaagacgta 2475361 aaaatcgagc atcccgtata cggagattta actgcagcca tccaagtagg cacccggaaa 2475421 gaagttagcc atttcatcaa aaaaatcaat tctacgaatg ctgcctactt atcacagctg 2475481 accgacggcg tgcacctgca tacactgaca gcacctgatg aacatcgcat cgatcaagcc 2475541 tgccaagccc tcgaagaagc cggcatttta attaaagact aaaaaaagcc ctctagtggg 2475601 ctttttttat aattggtaag actggtatgc acccagaagc ctcactttgc agccgagtgc 2475661 ttcaagctcc tgcatggccc ctggaatcaa tacatcatca aacgctttct caatatcaat 2475721 aataaagaaa taatggccta atccggtttt agtcggacgt gactcaattt ttgacaggtt 2475781 taaatttctc caagaaaatg cagacagcac tctatgcagc gccccggact gatcatcctg 2475841 cggcagcatg accattaagg tcgttttggg cctagagctc aattttgaat tcacttcaaa 2475901 agatatgttt tcatcgggag acaggataac aaatcttgta tgattgtccc tataatcctg 2475961 tatatcccgt ttcacgattt ttaattcgta tgtagaagct gccatatcat tggcaatgac 2476021 cccgatattc agctcgggat ggtcactgac aaactttgct gccgccccgg tagaattggc 2476081 gtattcatat ggaacggaag gaaaatgtcg atgaagaaat ttatggcatt gcgcaatcgc 2476141 gtgtgaatgt gagtaaattt tgtcgagctc tttccatgca ttctctcttg agggatggac 2476201 gagcaagtgc tggtgaatcg gcaacgtcat ttcacccacg attggcaaag gctgttcatg 2476261 tattaaatag tctattgtta gattaacaga tccttctaaa gcattttcca aaggaacaaa 2476321 agcaaaatca acttcgcctg caacggctgc atctatacac tccggaatgg tgcggtaagc 2476381 aacatgttcg gcgccgtttt gaaaacaaga actgactgct agatgtgtaa atgtagctgc 2476441 tggacctaaa taaccgactt tcatgacgat tttctctccc ttatgcacct gaacctaata 2476501 tttcaacctt ttctacaaaa tcaaacttcc tgagcttatt cattaatgta tgaatgtctt 2476561 cttccattgc cgacgtactg atagacagtg tcacatttgc tctgccttga agcggaatgg 2476621 tctggtgaat ggaaagaacg ttgcttccag aatcagctac cgcctgaaga agctgagata 2476681 acgcacctga cctatcctcc aaatgaaaga aaagtgtgat aatttgttct tttaccatgg 2476741 tgtagaatgg aaaaacagca tccctgtatt tataaaacgc acttctactt aaatcgacct 2476801 tttgaacggc atctgctact gaatctgctt tttttcgatc aagcagcttt ttgacttcta 2476861 atgtttttct cattgcatcg ggcaatacat cttcacggac aagataaaat gtctcctctt 2476921 tcatttgcat ccccccttta aaatagagag cctggcacca ggctctcttt tcagccaaca 2476981 ttgattaatc aataaattca aattcaaatt ccagaagcct gattatatct ccatccttgg 2477041 ctccgcgttc tctgagtgct tcatcaacac ccattccgcg catctgtctt gcaaaccgtt 2477101 taaccgattc atcacgtgag aaatcagtca tcttgaataa ccgctcaagg ctgtctcctg 2477161 aaagcacaaa tacaccgtct ggatcgcgtg taatgttaaa tggcacttct tcattttcca 2477221 tcgtgtacat gacacggttt tgtgtaagct cttcctcgtc atacagcggg aattccggtg 2477281 tgttctcaag ctgattggca acctcaaaca gaagctcacg cagaccttct cttgtcaccg 2477341 cactgatcgg gaataccgga taatcatccg tcagcttttc tttaaaggct tcgagatttt 2477401 ccgcagcctc cggcatgtcc attttatttg caacgataat ttgcggacgc tcagtgagac 2477461 gcagattgta ctcgctcagc tcctggttaa tcgtaagata atcatcatat ggatcacggc 2477521 cttctaagcc tgacatgtca atgacatgaa caataaccct cgtccgttca atatggcgca 2477581 aaaactggtg gcccagtccg acgccttggt gtgcgccttc aatcagccct ggcaaatcag 2477641 ccatgacaaa gctgcgtccg tcatccgttt caaccatgcc gagattcggg acaagcgttg 2477701 taaagtgata gtccgcaatt ttcggttttg cagatgagac aacagacagc aaagtagatt 2477761 ttcccacact cgggaacccg acaagtccga catctgcaag cacttttaat tcaagaacaa 2477821 tgtagcgttc ttttcccggc tcgccgtttt ctgaaagctg aggcgcggga ttagccggtg 2477881 tagcaaagcg gctatttcct cttccgcctc ttccgcctct tgcaatgaca gcccgctgtc 2477941 cgtgctctgt taaatcagcg atgacctgtt ttgtatcatc gtctgtcaca acggtgcccg 2478001 gcggaacttt aatgaccata tcatcagcat ttcgcccgtg ctggtttttg gacatgccat 2478061 gctcgccgcg aatcgcttta aagtgttttt tgtatctaaa atccatcagg gtgcggagac 2478121 cttcatctac ttcaaaaacg acgtctcctc cctttcctcc gtcaccgccg gcagggccgc 2478181 ctttcggcac atatttttca cggcgaaacg caaccatacc gttgccgccg tcgccgcctt 2478241 ttacatatac tttgacctga tctacaaaca taatgtcctc cgttctaaac cgttaaaaac 2478301 tccgctagtc caacccaatt tcaatcagac attcgtgact cgtgatttca aaacgcatga 2478361 tatcaacgtc ctcatatcca ttctgccgaa tatcatcaaa agcagatgga tcggcaaagg 2478421 cgccgtgaaa atcaaggtac agaatcagct gtctgtcagg atgatccgtt tgaagcgaaa 2478481 ccgttaaatg attttcactc tctctgctga ctgcttgatc aaacagatga aacagctttc 2478541 tcatcagttt cgccagcttt tgatcataag ccgacaaatc cttaatttct ccgagaactt 2478601 catattcaag cgtcatataa tgggttttcc aattaaacgt aagaaaatca aacgccaaat 2478661 gcggtgtttt caggtttgag agctttgatt cgtgctttgc gtctataacc atttcttcaa 2478721 tcatttcaaa gacacggtca tacttctgta agcttaagtt tcctttaatc agctgcagct 2478781 tattcatcca atcatgccgg gaatggccaa gcagatgaat cagttcgttt gttaatgccg 2478841 tgtcgcttat attttcttct tgattttttg aaacatcctt cattttcgca ctcccaatca 2478901 tttaatttct tatttaggag tctgtataag tgtgtattat gaattataac agagaaggct 2478961 ttgttagaaa aacaattgtt tttcccagaa atatcatgtt ccttttttct ggctttggtt 2479021 gatttgcagc caggcagaac attttatgta ttactgcttg gggaacatat ccagtgggtt 2479081 tgagatgttt attctcattc ttggcggggt ctgctcgcac atactctgca tttcattcta 2479141 ggtgtttact ccgcatattg caaaaaaaac tccagtcatc atcgaccgga gttttttgaa 2479201 tcattattga gctacaggat atacgctcac ttttttgcgg tcacggccga aacgttcgaa 2479261 tttaacagtt ccgtcgattt tcgcaaatag agtgtcatct ccgccgcggc ccacgttttc 2479321 acctgggtaa atttttgttc cgcgttgacg gtaaaggata gaaccgcctg ttacgaattg 2479381 accgtcagca cgtttagcac ctaaacgttt agcctcagag tcacgtccgt tctttgtaga 2479441 acctactcct tttttagaag cgaaaaactg aagatctaat ctaagcatgt agctcacctc 2479501 ctatattatg tttgtggtca cacgcaagtt gtctttgtaa tcccgttcga ttgtctccag 2479561 cgaaacaatc atgccttcaa tcagcagctg agctttttgg cgtgcctctg gatcaagaga 2479621 ttcagggaat tcaaaataaa aataaccccc gtcctctcct atatcaagaa gcggctcgaa 2479681 gcccgcgagc acaatgaccg cgttaacggc cccaaacaca acggctgtca ctccggcaca 2479741 aacaagatct tgtccatgtt cagcaaaatt cgcatggccc gtcatttcaa aagacaatat 2479801 gcctttatca tgagaccttc tgattgttgc ctgaatcatg cttacgcgtt gattttttcg 2479861 atcgtcactt tagtgtaagg ctgacgatga ccttgttttt tatgaacgtt tttctttggt 2479921 ttgtatctga aaacagtgat ttttttcgcg cggccttgtt tttcaacttt agccgttact 2479981 gttgcgcctt caactgtagg gttgccgact ttcacgttgt ctccgccaac aaacaaaacg 2480041 tcttcaaaag taactgtttc acctgcttca gcagcaagtt tttcgatgta aacagtttgg 2480101 ccttcttcaa ctttgatttg tttaccgcct gttttaatga ttgcgtacat tctctgcacc 2480161 tcctattaga ctaagactcg ccagatacca gggggctgta aaagctctta acacctgtac 2480221 tgagcggttg tagcaatggt gctacatcca taacattaaa aaatatacca aaatacaagg 2480281 cgtttgtcaa tcagttttag tagggcagaa gcagttcctc catggaagaa ttcgtccgct 2480341 tatcggcaaa gtaagcgtgc agcacttcat tctcgtcaag ctggctgagc ttttggcctg 2480401 atttttctat aataatcgga tgcttacagc cacgtttgaa ctcggccatc acatgataga 2480461 ctttatcctc cgcctttact gtcagcggca gaagtttctc aagctccctg ttttttccgt 2480521 aatacctttc gaggagaaat ctcacatgga tatagtgcct ttgccgatat tcctcaaaca 2480581 aggaaacagc cagaaagaca aacaaaaccc atgcgctgat ttgcagagga atcacgaata 2480641 aaacccagca cccgagcagc aggcagaagc agagcgacgt ttttagatta agccggtgag 2480701 ccttttgaaa aggcagctgt ttggaaaaca acaaaaataa cagttttcct ccatccagcg 2480761 gccagatcgg cagtaaattg acaaataaga tagaaagatt ataaaaggtg aagagttcaa 2480821 aggtatgctg atgaatcact gagacttctg caagcatcca ggcggcaaac tgaagccaga 2480881 tgtgctgaag aggtccggca ataatgaccg caaactcttc ctttaacggc cgattcccgt 2480941 gctcttccac ttcgaccgtt ccgccaaacg gcagcaaaaa aacacgcttg attctccaag 2481001 aaaaaaacac agccagagca gcatgcccca gctcatgaat caatacaatc aggagcagac 2481061 ataataatgc tttcatatgg cctgtgagca agcccagcgc cgcaataatc caaagaaaag 2481121 gatgcacatg gatctttaag ataaggtcga gccatttatt caaatgaaat cacctgaatc 2481181 ggatcaataa atttatcgcc gtctttcatg gcaaaataat agaccccttt attatgatca 2481241 tcaagcttaa tcgaaccgag ctttttgcct ttatccacaa aatcatataa agcaacatcc 2481301 acatctttga gctcgccata gatactatag gtgttgtcag catgctgcac cttaaccgtc 2481361 agtcccgttt ggctgtcttt gctgacttca accacatagc cttcttttac gctatcaatc 2481421 ttatcactgc ttgtttcgac tttaattcct tccccattgt cctgaaaatc ctgctgtact 2481481 ttcccggatg caggcgcgat cagatctttg cctacttcaa tctgctgttc cttatttttg 2481541 tgttcaggag ccaggaaagc aagcggattt ccgaatttgg tttcgaacca atggcttgct 2481601 gaagcaaatt gaaattcagt ttcaaaggtt ttggctacgg cgggtttaat ctgactgacg 2481661 ggtccaatgt ttgttttata ggctatagct gaaacgagaa caaggcaggc cgacagaaga 2481721 catttcagga taattgaatc tgttttcacc aatgggtgtt ttccgttgaa tgttggcatg 2481781 ttatcttcgt agaccggaag tgttccatgc ttttcctgat ccgttaccat cacccaggac 2481841 gggggtttct gcttttcaga aactgtctga gtagagaaac gttttgagcc ggaaagctgc 2481901 tttcttcttt tctctaatcg ttttctgatt tcatctgctc tgtgactcat tgccatcatc 2481961 ctttgcattc gttgggtttg tacatcatat gtcttgtcca tggcaaatat tcggtttagt 2482021 caagaacaaa gcaggcaaaa acaaaaaaaa cctgacacag catatgcttt gtcagattct 2482081 tctctttgat tctatcacat taagatctta ctccgaaaaa tgacttaatc ttagccatca 2482141 ttcctttgtt ttgctcttca agcacctgta aaggaacaga ttcacctaag atgcggcggg 2482201 caatattgcg atatgcaatg gaagcgcggt ttttagggtc catcgcaatc ggttcgccat 2482261 gattggaagc tttaatgact tcatcatcat cagccacgat tccgagcaaa tcgatcgaca 2482321 gatgctgtac gatttcgtcg atatccatcg tgtcaccgtt tttcatcagg tgatttctga 2482381 ttctgttaac aacgagccgc ggcggttcaa tattttcctc ttgctccagc agtcctataa 2482441 tacggtcagc atcacgaaca gctgagattt caggcgtagt gaccacaatc gctttatcag 2482501 ctccggaaac ggcatttttg tacccttgct cgattccggc aggacagtct atgatgacat 2482561 agtcaaattc ctgtttgagc tcttggacca tgtttttaat ttgttcagga gcaacagctg 2482621 tcttatcgct cgtttgagca gcgggcatta aatagagcag atcatcgaaa cgtttgtctt 2482681 ttacgagcgc ctgatgcatt ttgcatctgc cctctacaac gtctaccaga tcgtaaataa 2482741 ttctattttc aagacccatt acaacatcaa ggttgcgcag tcctatatca gtatctacta 2482801 agcatacgcg cttccctaaa atggctaagg cggtaccgag gttcgcagat gttgttgtct 2482861 tacctactcc gccttttccc gaagttatta cgatagcctc acccaattca cattcctccc 2482921 tcaagccttg ttagatcagg tcttaaatga gccaaatgtt gaaggcgttc aatgaccata 2482981 tttccgtctg tatctaaata agcacattcc atttcgttcc ctttttgaat gtggtctggg 2483041 gagcgattta acacatgatt gattcttaat tgtgtcggaa gcatttcaga ggcggcgatg 2483101 accgcttgat tatttccatt gaatccagca tgcgcaattc ctttcagtga gcccagaaca 2483161 aaaatgttcc ctccggccct gactgttccg ccgggattca cgtcaccgat caggagcaag 2483221 tcgcctttta cctgcagcac ttggcctgaa cggacaattt ttgaaacaga aataatttcg 2483281 gcttcctctc ttatctgctg tgcttctttt ttagtaatga cttcactgtc aatagaatga 2483341 acaaacaaat ctttctttga cgcaatcaat tcggttagct gttcctcttg ctccttatat 2483401 aaaaagcgat ttcccagctt aacatgaacg ctgattttct ggccttttcc atcggtatat 2483461 tgttcaattg acagcatatt ctgaagacca tcgagaagct catcaaaaga acacgcatca 2483521 tccagatgca atgttagtcc attctttgtt ccttttattg ttacatattg ctgctttttg 2483581 gtcttcacaa tattcacctc aacaacatac tcatttcgtc aaaaaaagat aaaatccttt 2483641 ttactcatct ctcaattctt tctttagact cataaaaaac aatctaaatg gcagaacaag 2483701 aataagagct gctgcaatat ttaataaaat tgtcggtata aaccggtcaa gcacaaatcc 2483761 gttaaacgtc ataatgtctt tatgaatcaa agactgaatg ccgaatacgt aaaattcgag 2483821 cagacagaca gccagaactg ctatcaatat cactacaaat gcgtttgtat gcaacacttt 2483881 aaacgctttt gaagccaaat agcatagccc tgcaaaacca aacatgtaaa cgcctaatag 2483941 acttgtatag ttcatgtcat atagaaagcc aaaaataaat ccgtaaatca tcgcgtgttt 2484001 ttggttgata aaagccgaca tgaatatcaa tacaagcatc aaaaaacgcg gggcgagcac 2484061 ttggtcatct gtaacgaaag gaaaatgcac caaatctgta aaaatgcttt ccgcagaaaa 2484121 aacaagcatc ataacgaaag ggagaaggaa acgtttcacg atccttcctc ctctgtatcg 2484181 acagtcggca cgtcacggtt aacaacgatc acattattta aatctgtaag gtcagccgca 2484241 ggttttacat aagcaacctt cgttaatcca taggaatctg actcgatatc agtcacttca 2484301 ccgattgtca gcccttctgg gaaaacaccg cctgtccctg atgtttcaat aagatcgcct 2484361 tttttcacgt cttgtttatc cttacgctca ataattgtca tcttaagacg ttttttctct 2484421 ttgtcatatc cttcgatcaa gccgtagcct ttgctgcctt tttttccgga aatttttgtc 2484481 gcgactctgt tattgcggtc agtatcgctt aaaagctgaa cagcagacgt aaaattgtta 2484541 agtccggagc ttttgatctt gccgattaat gcgccttttt cgtttgtaac ggccatatct 2484601 ttcgctacgt tttgctgagt ccccttgtta atggtgacct gtttcgccca attatcaggg 2484661 cttctggcga tgaccgttgc taaaatcggc ttgtaatctt taatcgattt gacatggcca 2484721 agctcgtcac gcaaggattt gttttcttct tcaagctctt gaagcttggc ttcatattgt 2484781 gtctgtccgt caagtttttc tcttagacgc tcgttttctt tgtatgtgtt ttttaaatca 2484841 ttgatgttct caaatattcc tgcaaaaaat tcggcaggcg tatgaaaaat attttgaaat 2484901 actcccgtcg tatcgccgat cactttctca ggccaggtgg tattgcggcc gcccttcagc 2484961 gaaaatccaa tcatagccac caatatgata atacacagaa gtaatagcat taaccgctta 2485021 ttcggcatcg tgttacacct cttctattga actcccgatt atctagtttt ccctttgaaa 2485081 agatggatgt gctccagtgc tttccctgtt ccgatcgcta cacaatcaag cggatcttcg 2485141 gcgataagga ccggcatttt tgtttcttcg ctgatgactt tgtccaaatt gcgcaaaagc 2485201 gctccgccgc cggttaacac tatacctctg tccatgatat ctgctgcaag ctcaggcggt 2485261 gttttttcga gtgtgctctt cactgcttcg acaattgtag atacagtgtc gcgtagagcg 2485321 ttagaaatct cttttcctgt aatttcaatt gttttcggca aacctgtgag caaatcgcgg 2485381 ccgcggattt ccatgttgtc ggattcttca ggagcttctg cagatccgat ttccatttta 2485441 atcgcttcag ccgtacggtc accgatcatc agattgtacg tttttctgat gtagttgata 2485501 atcgcgtcat ccatctcatc accggctaca cggattgact gagacgttac gatgcctccg 2485561 agggaaataa tcgcaacttc tgtcgtaccg cccccgatat caacaaccat gcttccagtc 2485621 ggttcccaaa ctggcagatt ggctccgatt gctgcggcaa aaggctcttc aatcggatac 2485681 gcgtcacgcg ctcccgcctg tcttgtcgca tcgataacag cgcgttcttc aacagctgta 2485741 atgcctgatg ggacacatac cattacatat ggttttctgg caaacatgcc tttatttttt 2485801 atggcctgat tgatgtaata tttcatcatc gtcgccgttg tttcataatc agcgataacg 2485861 ccgtctttca tcgggcgaag agccaccacg ttgcccggtg tccgtccaat catatttttc 2485921 gcatcatttc cgacagcgac aatcgatttc gtatccgtct gcaaagcgac aactgacggc 2485981 tctctcacaa caattccttt tccttttaca aaaacaagcg tattcgcagt tccaagatct 2486041 ataccaaggt ctctagcacc aattccaaac atatgtatgt atcttccttt cttaaagcaa 2486101 aaatacccta aagggaaaaa ctcataaact ctattatagc ttaattcgac gaaaaaaaaa 2486161 gtgttacaaa tatccttttt cctttaaact cacaaatttt ttatccccga tcaccaaatg 2486221 gtcaagcagc tcgatgccaa tcaggtttcc gcattcaaac agccgtcttg tcacttcaat 2486281 atcttccctg ctcggcgtcg gatctccaga aggatgatta tgaacacaga taaaggaagc 2486341 ggcagatcgt ttaaacgctt ctttaaacac ctctcgcggg tggacaatag atgaattcag 2486401 gcttccgata aatacggtgc gtttatggat gacttgattt tttgtattta agtataaaca 2486461 gacaaaatgc tcctgggtta aaaagcgcat atcctccatg acaagattag cgccgtcttc 2486521 cggggagcga ataacgaaat gttcttcgtt ggctaattta tgaatccggc ttccaagctc 2486581 aactgctgcc agtatttgaa tcgcttttac cataccgatt cccgggatgc ttgacagctc 2486641 ttcaaccgat gcttccttga gcaggcgcag cccgtcaaat gagcgcagca gccggtttga 2486701 caggtccaaa acagattcgt gtttagtccc tgtccgcaat aatatagcca aaagttcatg 2486761 attcgctaag ttctcggctc cgactttcag gagccgttcc cttggctttt ctttcattgg 2486821 gaaatctttg agttttaatg gcagatcgtg tatgaccaag cactcctttt ctttcccttc 2486881 ccgtttatag aaccgtcatg cccttatatc aaaatggcga agagctctca ttgtttttga 2486941 tataggaagg cccatgactg aataataatc tccgtctatt ttctttacaa aaagcgcgcc 2487001 tcttccttgg atgccgtatg cacctgcttt atccatcggc tcttttgttt caatatatgt 2487061 ccaaatctct tcttcactga gggaccaaaa cgcaacttct gtcttatcat aaaaagtctc 2487121 gctgtgattt tcagcttgaa tgctgaccgc ggttattact gagtgacttc ggcctgaaag 2487181 cctccgcagc atagaagcag cttcttcttg atcctgcggt ttgccaagac attcgccgtc 2487241 aaggcatacc attgtatcag caccgataac gattgcatgc gggtggagat cagctacagc 2487301 cttagctttt tgttttgcca accattggac gttttcttct ggtgaaaagt ttcgatttaa 2487361 tttttcttct acttcactga caataatgga gtagggcagc tggagaagat cgaggagttc 2487421 tttcctgcgc ggagattgtg atgcaagtat tagcggtttt gtcatgttcg tcatcctttc 2487481 agggtttgct taagaaaaaa agatactcgt ttatcctacc aaatcacgag gcttgtcaca 2487541 atttcagaaa aataactttt tcatgacaaa ataaaaaaag cctgtcacta aaggacgaag 2487601 gctcagggca ctatctctta ttttacgacg gctaacagct cctgctgagc cttccacccg 2487661 gcttcagcac ttggatcctc taattccttt aaagcctgca aaatcgcttt tttctctcct 2487721 gtttctgacg cttttgtttc accaagcgac ttttctattt tctctacact cgcttttgta 2487781 atgtcttcgt cgagaatcgc ctttgctgca agctccgctg tttccttaaa agaatctgtc 2487841 atatctgact ctattgataa ggaaagctcc ttgcctcccc aggcttcaaa atcactgtcg 2487901 attaaaacct gtcctaactg ctgtgagacc tccttttcac ttgctaagcc tgcaataaca 2487961 tacgtatacc cgtcatcctt tgacagtgac acggcggaat atcctttttc ggtcaattgt 2488021 tctgttaacg tttcggcgcc cttttcattt gaaaattttc cggcttgcac agcgtatgtt 2488081 ttgtatgtac cttcagtttg tgccgcttgt ttttctgcgc ctgaggtttg tttatcagca 2488141 gaagtatccc ctgcttttgc cgtttggctg cctaaagaat cctctaaaga ggccggtgct 2488201 gacgcttctt tattccccga tatgtttaac gcgaataacc ctaatccagt gccaatgaca 2488261 gccgcgaagg caatcgtcgc ggccactctt tttaccggtt tggcagcccc ggtctttcct 2488321 tttgcgtaaa gctttgtttt tttcttttga aaaggaggaa caactttagg gtcctcttta 2488381 aacaccttgt cctcctcgga atcccaattg aattcatctt catcagggtg ttcctgggat 2488441 gccgcaacct cttgttctgc ctgtcttttt tcctcccaat ttgaaaatgt catgctttta 2488501 ttcgcctctg tctcaggcgt ctcttgttcg taaaccgtct cttcttttcc attaatcgtc 2488561 accttgaggg ctttttctgc ggctttactg ttttttttat tctttctttt tttcaattcc 2488621 gcttcctccc ttcatttgct tgaccgttct tgtcggcttt tcatgctaca cactttagca 2488681 caggcaaaga aaaaaagaac aagacttttg tcgccttgtc caaaaaacgt tcgtcaaatt 2488741 tttcagcagt cagcccaatg ccattttgat ataaaaagaa atgatagagt caccgtataa 2488801 ataggctaaa atgctccctg cggctatagc gggggcgaag ggaagcggct gccttttagc 2488861 gagtctacca gtcagaacag ctgccgctcc atataatgca cctatcaaaa ctgaaaagaa 2488921 aaaggcagct gccagcattt tcacaccaag cacaaagcca atcaccgcaa ataatttaat 2488981 atctcctccc cctactcccc catgggtgat tgcggcaatt acagccagaa acaaaaatcc 2489041 ggctgccgca cctaacaggc ctgcatacca ggaatcaagc ggagaaatca atctcgcggc 2489101 cgccaaaaag ggaagaaaga aaatcaatat tcgatttgga atcagcataa aatgaatatc 2489161 tgtcactgca acaataatga gaagagagat aaacaccaca gcgggaaaca gttccagcga 2489221 tatgccaaag cgtattcctg cggcggcaaa taaacacgct gtcacaagct ctgctgcggg 2489281 atacataaaa gaaatcctat gcccgcagct tttacattta cctttttgaa ataggaatga 2489341 caggatggga attaattctg caggagttaa tgttcgccgg caaaacgggc atgatgaacg 2489401 gggcgcaata atagatagat gtaaggggat acggcacccg gccgtatagt aaaaagaacc 2489461 aaggataagc ccgaagataa aaagaatgga tagcatagac aacacacctt tactcattga 2489521 gttctggtat ggattgtagc aaaatggaca tcctgagctc caattgggaa tattcaattt 2489581 tacacatgaa aaaaacggca gaatcttttt ttgattctgc cggagccgga tgcttttatt 2489641 tcaacctttt tcgaatgtca gaaataaagt aaagagatcc ggtaatcagc acaatttcat 2489701 ttgagccctt tttactttct atgaatttga ttacatcgtc tggatcttca ctccagcttt 2489761 tattgctgat ttcacttgca tcatagagat cttttgcaag ggaagcacgc gggaaatcaa 2489821 aagaagcaaa atgaatcgca tgagcaatgg tttccagtct tttaatcatg ttctgatacg 2489881 gtttgtcctt taacgcgcta aacaccacag aaatgcgtga attggcgaaa cgctgcttca 2489941 tcgtttccgc cagcttttca acaccttctt cgttatgcgc accgtctaaa tataccggag 2490001 gatgttcctg aacaagctct aaccgtcccg gccaagcagc cttcacaagc ccgctcctta 2490061 acgcttcgtc actgatatgg gcgatattct ccttattgag ccactccgca gccaaaatgg 2490121 acaaagcagc attttgtctt tgatgggtgc caatcagaga tgtccgaata tcttcatagc 2490181 atttctcttc cgttttgaat gaaaactgtt ctcctgcagg cagagcctct tcattgaaaa 2490241 taacacatgc atcatgcaat gactggaacg gcgcagcatg ccgttcggct tcatggcgga 2490301 tgacctgtaa agcttccggc tgggtaactg ctgtaacgat tggaatacct tctttaataa 2490361 tgccggcctt ttctcctgca atttcttcaa tggtgtttcc caaaatgttc atatgatcgt 2490421 gtccgatgct tgtaatcaca gttaagagcg gttcaaccac attagtagaa tcgaatctac 2490481 cgcccagacc tgtttcaaaa ataacaaaat cgaccttatg aaactctgca aaatataaaa 2490541 atgcacaagc tgtcataatt tcaaattctg tcggctgtcc gtattccgtt tgatcaaggg 2490601 cttcaacgtg cggtttcatt tgattgacga gtgctgtcca ttcctcatct gaaatcggta 2490661 tcccgtttac gctgatccgt tcattaaacg taataatata aggcgatgta aatgttccaa 2490721 ccgtatatcc ggcttcctgc agcatagaac ggataaaagc gacagttgat cctttaccgt 2490781 ttgttcctgc gacgtggaac gctcggattt ttttttcagg atgtcctaac cgcgccatca 2490841 gctgtttcat tcgaccaagt ccgggcttca ccccgaattt cagcctcccg tgaatccagc 2490901 tgcgcgcatc ttgatatgca gtaaacaatg ataatcccct cttttataag acaaggcggt 2490961 ttctctagaa accgccccgg cttttcatta acccttcagc tcagccattc gtttttgaac 2491021 agcgtcacgc ttcgccacat aatctttttc tttttcacgt tcttcatcaa ttacgtgtgc 2491081 aggcgctttt ttcataaatc cttcatttcc aagtttcttt tggacacgct caacttcttt 2491141 tgtcagttta tcaaattctt tttgcagacg ggcaatttct tcatcaatat tgattaagcc 2491201 ttcaagcgga agaataacct ctgctcctga gacaacggcc gtcatcgcct tatcaacagc 2491261 ctcaatatcg gtgccgattt taagcacgct cggattcgta aagcgttcaa catatgaacg 2491321 gttcgcttcg aggcgggacg ctatttcgtc tgtgcttgtt ttaatgtaca gttcaacctg 2491381 cttgctcatt ggcgtattga cttcactgcg gatattgcgc acagaacgga tcagctcaac 2491441 aagaagcttc atgtcagctg ccgcttcagt atcggtatgc tccggcacta ctgcaggcca 2491501 ttgacttact gtaatcgatt ccccttggtg aggaaggtgc tgccaaattt cctccgttaa 2491561 gaatggcata aacggatgga gcagacgcat cgtttgatca agtacgtaag caaggatgga 2491621 acgggtagtt ttcttagccg cttcgtcttc tccataaagc ggaagcttcg ccatttcaat 2491681 ataccaatca cagaaatcat cccaaataaa gttatataaa tggcgtccta cttcaccaaa 2491741 ttcatatcgg tcagcaagct gggtcacgtg ctcgatcgtt tcatttaatc gcgttaaaat 2491801 ccacttgtca gcgactgact tttcacctga cagatcaagc tcatcgtacg tcatgccatc 2491861 catattcatt aatgcaaaac gggaggcgtt ccaaatttta ttggcaaaat tccaggtcga 2491921 ttccactttt tcatagctga agcgcagatc ctggccagga gagcttccag tcgcaaggaa 2491981 ataacgcaga gaatcggctc cgtacttgtc aatcacatcc atcgggtcga caccgttgcc 2492041 aagagattta ctcattttcc ggccttgctc gtcacggatt aagccgtgga ttaaaacatc 2492101 tttgaacggg cgctcgcctg taaattcaat gccttggaaa atcatgcgtg atacccagaa 2492161 gaaaatgata tcgtaccctg tcacgagaac atctgtcgga tagtagcgtt taaagtcttc 2492221 agccgttaca tcaggccagc ccattgtgga gaaaggccat agcgcagaac tgaaccatgt 2492281 atccagtacg tctgtatcct gttcccaatt ttcgctgtct tccggcgctt caagtccgac 2492341 atatagctcg cctgtttctt tatgatacca ggcaggaata cgatggcccc accacaattg 2492401 acgggagata caccagtcgc ggatattttc catccagtgt aaatacgttt tttcgaaacg 2492461 gtcaggcaca aagttgacct tttcttcttt tttttgcagc tcaatcgctg catcagcaag 2492521 cggctgcatg cgcacaaacc attgtgtaga aagataaggc tccacaacag ccccgcttcg 2492581 ttcactatgg ccgacagagt gcatatgatc ctcgatcttg aagagaactc ccgcctcctg 2492641 taaatctttc acgagctttt tgcggcattc aaaacgatcc ataccttgat attggagcgc 2492701 attttcattc atcgtgccat cttcattcat gacaaggatg cgttctaaat tgtggcggtt 2492761 gccaagctcg aagtcgttcg gatcatgagc aggcgtaatt ttcacggcac ctgaaccaaa 2492821 ttccatatca acatagtcat caccgacaat cggaatttca cgatttacaa tcggcaggat 2492881 caccgttttt ccgataaggt gtttatagcg ctcgtcttca gggtgaacgg caacagctgt 2492941 atcaccgagc attgtttcag gacgtgtcgt cgcaatttca attgagcctg aaccgtcagc 2493001 aagcggatag ctcatatgat agaatgcgcc ttgaacatcc ttgtaaatca cctcaatgtc 2493061 ggatagggct gtttttgtcg ctgggtccca gttaataata tattcgcctc tgtagatcag 2493121 gcctttttca taaagcttaa cgaatacttc ccttaccgct ttgctcaagc cttcatccag 2493181 cgtaaaacgt tcacgggaat aatctaggcc aagacctaat ttcgcccact ggctgcgaat 2493241 aaagtcagca tattcttcct tccacttcca cgtttcttcg aggaattttt cacggcctaa 2493301 atcgtagcgg gatttgcctt cttcacgaag tttcgcctcc actttagcct gtgtcgcgat 2493361 gccggcgtgg tccatgccag gaagccacag cacatcatag ccctgcatgc gtttcattct 2493421 tgttacaatg tcttgcagcg ttgtgtccca tgcgtggcca aggtgaagtc tccctgttac 2493481 gtttggcggc gggatgacaa cagagtatgg ctcttttgtc tggtcactgc ccgcttcaaa 2493541 aaatttgcct tttagccaaa aatcatatcg gtctttttca accgctgccg gatcatattt 2493601 cgtcggcatt gtttgttcat tcgtttccat cataaccctc cagcatgttt aaaaatggct 2493661 gagaacgaaa aaagagctct tcatccctgt aaaaggacga aaagctcttt cgcggtacca 2493721 ccttttttca tgaactcaat cagttcatgc acttataacg gataacgggt gtttcccgaa 2493781 tttctctact cttctttcaa gaaattatgc tcccgggcga ccttccaatc agacaacata 2493841 agaagccttt cagcaaacgg cttctctctc tgcatgcgcc ttttttgtac tcttcccgtt 2493901 ctaagcaggt gtatttatca gctcattgta tacattattt atgttcttta ttatagtaaa 2493961 agtgtttttg attcgtcaat catcttttcc aaaaacaccg ctttctatac agatgggcag 2494021 gcacctattg cccaagttta catatgatgc ttgtaaatgc gtagaggagg atgcaccgtg 2494081 aagaaacgtt tcagctctta ttcgctgccg ccatgggtaa ggcaaattcg gcttgtatcc 2494141 gcacaagtga ttattcccat tacgattttt caaggaatca gaaccatttt ctttccgaca 2494201 acctttgatg ttttgctgct cgcaatccta atctttttag cttgcgccct tcatttagaa 2494261 tggatataaa caaacaagtc cgcgccatta agacgtggac tcgttttcag cctgaaattt 2494321 tttctcttgt tcaatctgat gaattttcat cacaaacggc tctatgtttt tcatttgcca 2494381 ataagccttt aataattgtg tacattcctc tttttcatgc tgtcttttcc cagtttgata 2494441 accgttcagc accttgtaca tggctgccgg atatgccata tagctgagaa aaaggctgac 2494501 ttccgcttca cgcaaaggga atgatttcgt atatccataa aaccattcga cgcattccgg 2494561 acaagctttc ggaaagcctc tgaacatttt tgtataaaag ccgagcaggt cgttttgcgg 2494621 cggaccgaca gatgctcttt cgaagtttgt aaaatatccg gtcccggcat cattatacag 2494681 aaaatggtgt atagacaggc tgccgtggtt cattacaacc cttgaaacgt ccttttcctt 2494741 tgcggactca taccagtcct ccagccgttc cagcgcaaag ttcaccgcgg aaatggtttc 2494801 agaaaaatag gttatggcct ggagttcaaa gggagaaagg taccattcct tctccgctct 2494861 atccacaaac tgctcataga aaattttatc ttgttcccac ttttttttcg tttgcccgta 2494921 ataacgttca atctcatcac gtctaacctt tagttcctgc gcggttctct cgtgaagacg 2494981 ggctgtttct ctaaataaat aagcatgttt ttgatcccgt tcttcctctt ggtcaaattg 2495041 gagccaaggc attaaatagt agatatctcc gtattgtatg cctgctgaga aaaactcacc 2495101 gctatttgtt ctgtaaacgg gaacgaatga acgaaagcct ttttcctcaa tcgccaccat 2495161 atgatctgta aaatgcttgc cgcgaccttc tttcaatttt ttcagggcaa atatgccgta 2495221 gtctgtatac actttccaaa caagaggact gacaggctca ataaattgag cagtcagtcc 2495281 gtattcctga agaaccgatt gggtatcttc catttcattc accacatttt ccgatcactt 2495341 acggtttacg catggctatt tttatattga ggaatataga gaatctgtcc tgcttttaat 2495401 tcatcatcca aggctaaaga attcatcctg atcagctgct gggatgtaat ttcataccgt 2495461 tcgcataaac gctcgatcgt atcttcctgc tgcacaatac aaattttcat tctcgaaaac 2495521 tcatccgctt cttttgtaaa gagttttgtt aaataaagag aattatcact ttcctttgtt 2495581 tgaggttcct tcgtttcagc agcaggagca accctaggaa cagcatccgt ttccttcctt 2495641 tcagtctcag aagattcagg cagctggaag gattgaaaag gtgtttcttc cttaggctct 2495701 tcagctgatg gtgtttttct cacttcaatt tcgaagctct cttcctcttg ttcttcctcc 2495761 tccagcagct taggcgctga ataaaaagaa tcctcctctt cttgttcagg caggaaggta 2495821 cggtatgccg gttcaggcaa ttcttcttga gatgcctcct ccgagcttgt tttttgattg 2495881 aaatggaaat gtaaatcggc attgtcattc tccatatata cagctgaagc tgtttctctg 2495941 ctatcttcta tggagagagc ggcctctgat acactctcca aagcttcatc cggttccgcc 2496001 tcttcttggc aaagcgcagg atcagcctga tccgattgag ctgcttcttc attttgagcc 2496061 tcttggcgca gcgcatattc atgattagga gacactgttg tttcctcttt ttcctttgca 2496121 atcacagtct ctgaatgaag ctcagcttcc aaagcaggcg attcttctgc tccaacgtgt 2496181 tcacgaagct cagtctccgc tggagagtct gcttcttcac gaacatccgc tattgcagct 2496241 gccggctctg ccgtttcttt ttttgcttta acgatctctt gaatctctat ttctgaagga 2496301 tcaggttctg gctcagattc ttctgtttcc gattcagcac gaacctccgt ttccggcaca 2496361 gcaagctctt ctgactcttc ttcctctttc acatcttctc tggcctctgg ttctgaagca 2496421 accgattcag gcggctcaga ttctgctttt tctgtctcca gttcttcacg gagccccgct 2496481 ttcgagataa aaagttctgg cggttcggct ggcggttcat gctgaagaac tgcttcctct 2496541 gccgatgatg cacccggttc ttctactaca ctatgtgccg gcggctctga aagctcttcc 2496601 tccctgaatg ccgcaggagc ttcatataaa ggtatctccg gctctttgtc ttgcgtatcg 2496661 tccaaaagcc cttcgatcgc taaatcagct tgaattgtta aaatgcgcga atccgtcaat 2496721 tgatagtcaa atgcgtcaat aaagacgaag acatcctgta aatggctcac tttatttttc 2496781 ggaatggtaa tatccacagg aaaacagtga gtcagttccg cacttccatc ctctctcttt 2496841 ctgacttgtt caacaaaccg cttatctgta taaatctctt cggtatgttt gttttgatct 2496901 atgttgtact cacctgtaag ttcaagcgat cctatgattg atacataatc atttacttcc 2496961 tgaaccctaa tatcaggatc taatgaaata gaaagcagtt cagaaacttc ctgtcctttt 2497021 tggaaacaga tcgattcttc tacagaaaat tgcaatcgat gattttgcgg caagttcata 2497081 tcctcctttc atctaatcct taaaattaga tgtcactaaa ggtgtatgta tgaactggag 2497141 aaaatatgag tgggagagca cgaaaaaacc ggcacaagga gtccttgata ccggttttca 2497201 ctcttatctg cggctgatct cagcaaatac tttctcagct gcctggattg tgttttcaat 2497261 atcttcatca gtatgggccg ttgagaggaa aagaccttcg aattgtgatg gcggaaggaa 2497321 taccccttca tttgccatcc ctttataata gcttgcgaac agcttcaaat cagatgattt 2497381 cgctgtttca taattgatga ctggttcgtt tgtaaagaag aaaccgatca tcgaacctgc 2497441 acggttaaag gtatgcggaa tgccatgagc cccggcggtt tttgaaattc cttcttccag 2497501 tctgtcgcct tttttgatga aattcttgta ggattcaggt gtcagctgtt tcaatgtctc 2497561 taagccagcc gtcatcgcaa gcgggttgcc tgacaatgta ccagcttgat agatcggacc 2497621 gcttggagcg atctgctcca tgatttctgc ctttccgcca taagcgccga caggaagtcc 2497681 gcccccgatt acttttccta aacaagtcag atcaggcgtt acgccgaagt agccttgagc 2497741 gcagttataa tcgacccgga agccagtcat cacttcatca aaaatcagca gggagccgta 2497801 ctgctcagtg atatcacgca gaccctgaag gaaaccttct tgcggcggaa caacacccat 2497861 atttccggca actggctcta caatgactcc cgcaatgtct tcaccgaatt gctggaaagc 2497921 aagctttaca ctttctaaat cattgtacgg aacggtgatg gtgtttttcg caatgccttc 2497981 aggcaccccc gggctgtcag gcagaccgag agtggcaaca cctgaaccag ctttaatcaa 2498041 gagagaatcg ccgtgtccgt ggtagcagcc ctcaaatttt aaaatcttgt tgcggcccgt 2498101 atagcccctt gccaaacgga gggcactcat tgtagcctct gttccggagc ttaccattcg 2498161 tacaatttct acagatggca cacgatcaat gacgagctta gccagttcat tttctacttc 2498221 agtcggagca ccaaagcttg tcccgtattc agccactttt ttgaggcttt ctacgacgcg 2498281 gtcatttgta tgccctaaaa ttaaaggccc ccatgacaag acgtagtcaa tatattcatt 2498341 cccgtcaata tcaaagattt tcgagccttt tccgcgctcc ataaaaatcg ggtccatgtc 2498401 taccgattta aatgcgcgaa cgggactgtt cacaccgccc ggcatgagtt tttgcgcttc 2498461 tttaaaagcc gtttttgatt tttcatagct tctcatctgc ctcaactcct gtcaactgaa 2498521 taaaattact ccgcaagcca tttcgctgcg tctttcgcat gatacgtaat aatcaggtcg 2498581 gcacccgcgc gcttcatgct tgtcaaaatt tccaacacaa tttctttttc tttgatccag 2498641 ccgttctgcg ctgcagcctt caccattgaa tactctccgc ttacattata agcgacgagc 2498701 ggcaaagtaa actcattttt tacgtcacgc atgatatcca tataagaaag cgaaggtttg 2498761 acaatcaaaa agtccgcgcc ttcctcaaca tctgattgtg cttcgcggag tgcctccata 2498821 cggttggcag ggtccatctg atatgttttg cggtctccga attgcggtgt gctgtttgct 2498881 gcatcacgga acggaccgta aaactcactt gaatatttaa cagcgtaaga catgatggga 2498941 atattgacga atccttcttt atcaagtgct tctctgatca ctgtaacaaa tccgtccatc 2499001 atgtttgatg gcgcaatgat atccgcacct gctttcgctt ggctgacagc tgtctgcgcc 2499061 aaaagctcca gcgattcatc attgagaatg actccgtctt tgacaagtcc gcaatggccg 2499121 tggtctgtat attcgcacag gcacgtgtca gcgacaacaa ccatttcagg gaagtgttct 2499181 ttaatttctg tgatggcttt ttggacaatt ccgtgatcat ggtacgcttg tgttccgcaa 2499241 tcatcttttt cttccgggat gccgaacacg ataacagatt gaatgcccag tttgaccagc 2499301 tccgctactt catccttcaa taaatctaat gatacatggt gaacatcagg cattgacgga 2499361 acagcttttt tgccttccag cccttcaacg acaaaaatcg gatatataaa atctgatgga 2499421 tgcaaacgtg tttcctttac catttctctc attgcttttg atgtccgcag gcggcggtgt 2499481 ctattaaatg attgactcat attctctctt cctctcttga catgctgcac attaactcaa 2499541 gcatgccatc tattgtaaat gtatcaggcg tatgcgatgt gatgccgtac gtcagaaggg 2499601 catcatttgt taaaggccca atgctgatac aggccgtccc attcgccttc cactttttta 2499661 attcttctcc caagacatgc ataaacgtat gtacggttga tgaactcgta aatgttacat 2499721 agtcaaagga atattgaccc gcagcgtctt tcaatgcctc aatgccttct tcatccggaa 2499781 tcgtttcgta gagaacccat tcctttactt caaaaccgag cgggacaagc tcttgtttta 2499841 tcacatcacg tgacaaattc cctttcatca cggtaatggt ctcccccggt tcagcatgct 2499901 gcttaagagc gtcagccaat tgttcagcaa tatactcctg tggcatcaca tcaaccgata 2499961 cgttatgcat ttttaaacgg cgcgcggttt tttcaccgac ggctgcaatt tttttatgcg 2500021 cagggagaat aagctgattt tccttcagat aagaaaaaaa gaagtctgcc ccgttcacac 2500081 ttgtaaaaac aagccagcct ggcgcggcaa gatcctctct tacctgttcc gcaacatcat 2500141 tcggcaaagc gcggcgaaac gtaatcaaag aggttaaaac cgctttaccg ccaagcgcct 2500201 ccactttttg ctgaaatgat gctgcctgtg ccttattccg ggtgacaagc actgtttttc 2500261 ctttcaacgg aaaatcattt tccatcctcg tcaagctccc gttttacacg atcaattaaa 2500321 tcttttgctc ctttgtcagc cataagagcg gcacagcgct ttcctacttc ctccggatcg 2500381 tttccggtga cggtttcttt aaaaatgatt ttgccgtcag gtgaagcgac aagacctgtc 2500441 atttcaattt catcctgtcc atttaacacg gagtagcccg cgatcggaac ctggcagccg 2500501 ccctccatcg cgtttaaaaa agcacgttcc gctaagacag tccgttttgt atattcatct 2500561 gtaaactgag aaaacaacgc caacagctct tcatccgatt ctcggcactc aatcgccagg 2500621 gctccctgcc ccacagcagg caaacagcgc tcaggctcaa ggaattcggt tacgacatct 2500681 tgcttccaac ccattctgga aaggccggca gccgctaaaa taattgcgtc ataatcctct 2500741 gtttccagct tttgaagtct tgtatctata ttacctctaa tccatttaat tgtaaggtca 2500801 gggcgctcaa tcaaaagctg cgcgcttctt cttaaactgc ttgtgccaat gacagcacct 2500861 ttcttcattt ctgaaagctt tacgcgattc tttgaaataa gggcatcacg cgggtcctcc 2500921 cgttcaggaa tacagccgat cacaaggcct tcaggcaaaa cagcaggcat gtccttcatg 2500981 ctgtgcactg ccatatcaat ctcttcgttt aaaagcgcct gttcaatttc tttgacaaaa 2501041 agcccttttc cacccacttt tgagagtgta acatcgacaa tccggtcgcc ctttgtcacg 2501101 atctctttaa tttcaaaagc aaacgaagga ttgatttcct tcagtttttg aataacccat 2501161 tttgtttgag tcatagcgag tttgctccgt ctggaaccta ctttaatcgt tctcatcatt 2501221 tctttcctcc cgaatctgct tgggacatcg tttaactgaa ccaatggaat tgcgacaggc 2501281 ttccaagcag gaaataattg atcatcagca ccagaaaaca agccgtattc cacagtgcag 2501341 cgacctttcc ttgcagctcc ttaatcagcc tgatataaag ataatagctg tacagcagca 2501401 ggacgacaaa cgaaccaagc actttggcgt caaaccaata cagcgtttct agtgagacat 2501461 acgcccaaat gacgccgaga atcaaactca gcagcagcat cggaacccca atgacattta 2501521 aaacatacgc catataatca agcttagata aatcttctat tctcaacagc cattttcccc 2501581 actttttctt tttcagcaga tgatattgaa acatatatag cacagaaaaa acgaaagaaa 2501641 gggaaaaagc gccgtatgaa agaatcgcca ttgtaatatg aatcaccaaa agctcggata 2501701 caagctgccc ggaaaaagca gctgactgct gctctgtcgg tgaaaatgtg tgaatggcga 2501761 tcatagaaaa tcctataaca tttgtaaaaa acacgataaa gtcaacacgt aaaagctttg 2501821 tcagtacaag tgacagcgtg acaagcaccc aggcataaaa ataaagtgcc tctgtcacat 2501881 ttaataccgg aaaccgcccc gtcacccaca taaaataggc caaatacacg gtttgcagag 2501941 tccagacaat agaaagcaac cagaaggcca tttttccagc cttccggttg tgttgaagaa 2502001 aatctataaa ataaaagagt acacttaacg cgtaaatgac gattgtcccc tcattaagtc 2502061 ttgccattgc agtatcaatc attcagcttt cactcactta caagtgggct aaagcccgct 2502121 tttgattcag ccttcttaaa agagtggacc ttctggctgc tttcaacggt tttcatcatt 2502181 tgacggcccg cagcttcttc aatatcaaaa atctgcataa acaacgcgag cttttcttca 2502241 gaatcagcat ctgccgcaag ctctttcacc tttaaaatcg gatcacgaag catttggtta 2502301 ataatacttt tggtgtgttt gttcaacagt tttttctctc ttgtgcttaa gtgaggcagc 2502361 ttacgctcaa tgctgtccat cgtttctgac tggatggcaa gcgccttttc gcgcaatgca 2502421 gaaataacag gcacaacacc aagtgtattc atccattgtt taaattccac aatggtttct 2502481 tcaattaaca gttcaacttt ttcagctgtt tctctccgct ctttcatgtt cgcttctaca 2502541 atgccttcca gatcgtcgat atcataaaga aaaacacctt caagatcatt cagcgccgga 2502601 tcaagatctc taggcacggc aatgtcgacc ataaacagcg gacgtccctt gcgaagctta 2502661 ttcgcgtttt ccatcatctc tttggacacg acaaattcac ttgcaccggt tgaactgatt 2502721 aaaatatcag cctccgcaag cgcgctttca agctgattca agcttctcgc ttcacctgaa 2502781 aaacggtctg caagctcctt cgctttcaag tatgttcggt taatgacagt gaccttgccg 2502841 attccctgtc cgtgcaggtt ttccgcagca agctcgccca tttttcccgc accgagaatc 2502901 aatatgtgct tgcttgaaag atttccgaag atttttttgg caagttcaac tgcagcatag 2502961 cttactgaca ccgcatttga gccaatgtct gtttcggcgt gagtccgttt gcccactgta 2503021 actgcctgct taaacagctc attaaaaata gtcccgatcg ttttttcttg ctgagctgtt 2503081 ttaaagctgt cgcgtacctg tccgagaatc tgcgtttcgc caatcaccat agaatcaagt 2503141 ccgcaggcta cacggaataa atgctcaaca gcggcatcgc tctcataaaa cgttaagaac 2503201 ggtgacagct cttctttgct taattgaaac caatcagcta aaaacttttt tatataataa 2503261 cggccggtat gaagctggtc gactaccgca taaatttcag tgcggttgca ggttgagaca 2503321 atgatgtttt caagaatgct tttctcttct ttcagctgca ccattgcttc tgccagctca 2503381 ttcggctgaa aacttacttt ttcacgtatc tcaatagggg cggatttata atctactccc 2503441 acaacaagta tatgcatcgc tctaattaca cccccaacac ccaatcttaa tttataatca 2503501 ttctaacata gaactcatta tttataataa ttataacata gtttctttca caaaatgtga 2503561 acagatttta aaattcttat gctatattag aaaaagcttc agggaaaaga agcattccta 2503621 ttgacaatac caaaaacagc agaaatttac tacacatcag ctctaaaaaa caagaaggtg 2503681 atatgcatga aacaaaaatc aattttattc ccttgtctgc tgcttgccgc ttctgtatat 2503741 gcatggctag aaagcggcca agccgaactg ttttcagggc aggatcaatg gcctgttctc 2503801 ctcatgctgt taggcgcagc ctttgtatat caaggaaaaa aagaagccgt cacaccccat 2503861 ttttttatcg gtttgcttct cttcgggatc ggtttacact tttttgccaa gccgaaatgg 2503921 gtatggtggc cggatgattt tgaaatgctc ctctttatga tcggcttctc acttctcgtt 2503981 tcaaccgttc aaaaaaaaga atatgtatat gaagctgtgt cgatgatttg tttttccctg 2504041 tttttgtact ttttcaaaca aattatggca tggcttgagt ctgcgcatat tccaacagcg 2504101 cttctgaagg agtattggcc gtttgtcttt attggaatca gtttattgtt attattgata 2504161 aaacgaaaaa aatctatacg ataaataaaa ccggtagagg atcctctacc ggtttatcat 2504221 ttttttgatc gctccccaag cttcgtcttt tccctttttc gtttctgaag aaaagaggat 2504281 cagctcgtct tccggatcaa tatttaatgt ttgtcggaca accttcgcgt gtttgtccca 2504341 tttacctttc gggatcttat ccgcctttgt agcgataaca ataacaggaa tgccgtaata 2504401 ctttaaaaat tcatacatct gtacatcatc attagatggc gcatgccgca aatcaacgat 2504461 ctgcaccaca gcttttaatt cctcgcgtgt cgtgatatag gtttcaatca ttctgcccca 2504521 tgcttcacgc tcagactttg acactttggc aaaaccgtag cccggcacat ccacaaaatg 2504581 cagctcatca ttgataatgt agaaattaag cgtttgtgtt tttcccggct ttgatgacgt 2504641 tctcgcaaga tttttgcgat tgattaatga attgataaaa gacgattttc ctacgttcga 2504701 tcttccggcc aatgcgattt ccggaagccc cccttcaggg tactgttccg gttttactgc 2504761 actgatcacg atttctgact ttgtgacttt catttcttct ctcctactaa ggcatgttcc 2504821 aaaacctcgt ctaagtggga cgccaatata aatgtcagcc cctccctgac gctttccgga 2504881 atatcctcta tatctttttc attatcttta ggcgcaataa tggtcgttaa tcccgctcta 2504941 tgtgcgccaa gcgctttttc ctttaagccg ccgatcggca gcacgcgccc gcgaagcgtg 2505001 atttccccag tcatgccgac ttcacgcgaa accgcccgtc ccgttaaagc agaaacaagc 2505061 gctgttgcca tcgtaatacc ggctgacgga ccatcttttg gcaccgcacc ctctggtaca 2505121 tgtatatgaa tatcatactt ctcatgaaag tcaggttcaa tgccaagttc ttctgttttg 2505181 gatcgcacat agctgaatgc agcctgagca gactctctca taacatctcc gagctttcct 2505241 gtcaggatta atttcccttt tcccggtgaa agcgatactt caatcgaaag cgtatctccg 2505301 ccaacggttg tatacgcaag ccctgtcact acaccaactt gatcctctgt ttcagcttgt 2505361 ccatatctga aaatgcgttt tccgataaaa tcttgaaggt tcttctcagt aaccgtaatt 2505421 cgttttcgct cttcagcaac aatggctttt gcagctttac ggcaaattgc ggcaagctgg 2505481 cgttcaaggc ttcttacacc cgcttctctc gtatagtaac gaataatatc aagaatcgcc 2505541 tgatcacgca gctgaagatt gcttttcttc agcccgtgtt ctttgatttg ctttggaagc 2505601 aagtgatcct ttacaatttc aagtttttct atttctgtgt agcctgcgat attaataatt 2505661 tccattctgt ctctgagcgg gcccgggatt gtggccaaat tgttcgccgt tgcgataaac 2505721 agcactttgg ataaatcaaa ggtttcttca atatagtgat cactgaagct gctgttttgc 2505781 tctggatcaa gcacttcaag catagcggat gatgggtctc ctctaaaatc agatgacatt 2505841 ttgtcaattt cgtctaataa gaagaccgga ttcagcttgc ccgctttttt catcccttga 2505901 ataatacgtc caggcattgc tccgacatag gtccgtctgt gtccgcgtat ctctgattca 2505961 tcccgaactc ctccgagtga gattctgacg aatttgcgtc ccaagctttt tgcaattgat 2506021 ttggctaaag acgtttttcc gacacctgga ggtcctgcca aacagagaat cgggcctttc 2506081 agggattttg tcagcttctg gacagccaaa tattctaaaa tacgttcttt tactttttca 2506141 agcccgtggt gctcttcgtc caagagacgt cctgcttctt tcaaatcaag cttatcatct 2506201 gtttcatccg tccacggaag agcaaccagc cagtcgatat agttgcggat cacagagctt 2506261 tccgcagaac ttgacggaat tttttcatat ctgttcaatt ctttaagcgc tgtttctttc 2506321 acatgatcag gcatgcctgc ttcttcgatt ttttccgtca gcgtctgaac ttcgccagtt 2506381 ttgccttctt tatcgccaag ctctttttgg atcgccttca tttgttcacg caagtagtat 2506441 tccttctgcg tacgctccat cgaacgtttg acgcgctggc cgattttttt ctcaatctcc 2506501 agcacttctt tttcattatt aataaaatca atgaccttgt tcagcctgtc tttgacatca 2506561 gccgtttcta aaatatcctg cttatccttt agtttaaggg gcagatgaga agcaacgatg 2506621 tctgccattc tccccggctc ttcgatatca gtaaccgcag cgtacgtttc ggccgagatt 2506681 tttttagaaa tttttatgta ctgatcaaag tggtctagca aagtccgcat caatgcttcg 2506741 tcttctgtat cttttgaatc atcttcatga ataagttgaa tgtcaaccga cgtgtaatcc 2506801 tcgtgttcat tgtatttgac gatatgggcg cgcttgaggc cctccaccaa cacacgaatc 2506861 gtaccgttcg gaagcttcag catttgctta atttttgtat aggtgccgac agtgaaaatc 2506921 tcgtcttcac caggttcgtc tatcgaaata tcctgctgag tggctaaaaa tatcatatga 2506981 tcatgcatca ttgcctgttc aagagcctga accgacttgt cacgtcctac atctaaatgc 2507041 aaaaccatcg tcgggtacac taataaacct cttaaaggga ggagcgggat gctgcgtttt 2507101 aattcttctg ccatgtgact gacacctccg tgactttagt atgaaccatt ataatacaac 2507161 tttttcatcc ttgtacaata aacggcatgg ttccattttc tataaaacag tctcctcgta 2507221 gtataccctt tctttctgat atgaaaaagg aaaagatgtc cttcatgaaa aaaaccctat 2507281 tatcaaaata gggtttaaac ggattcttta ttgatttcga tatgaaacgg tttttgttcc 2507341 gttggcggat tcaccaaaat ttcatcaagc acttcttgga acgtcttcac tgcaataatc 2507401 tcgatcccgt caatctgctt taagatggcc tgctgatttt catatgggat aatcaccttt 2507461 ttcgcaccgg actgcttggc cgcttttatt ttcggaatga cgcctccgat gggtttcaca 2507521 agaccgttca ggctgatttc gcccgtcatc gcaacggtat tgtcaatagg aattttgtgt 2507581 atcgccgaga aaatccccgc cgccatcgca atgcctgctg acggcccatc aatcggaatc 2507641 cctcctggga aattgatgtg aatatcataa tcagaaggct tcattcccat tgtccggagc 2507701 acggttaata cattttcaac cgaacccttc gccatgcttt ttcgcctgat cgattttgat 2507761 tggctgccga tgctttcttc ttcagctatt cctgtgatgt taattgatcc tttatcttga 2507821 gccgcggtta cacttacttc gatttccaga agcgatccgc tgttaggccc atagactgca 2507881 agcccattta caatgccaac ctgtggttca acaccgattt tttgctcgtg ctttggagta 2507941 agctgactgg agtgaatgac ccattcaata tcctcaatcg taatgtcctt tcgattctcc 2508001 gttacagcca tccccgctgc gatttgaatc atattgacgg cttcccgccc gttccgcgtg 2508061 tagctggtca aaagatccag tccttcttcg gagatatttt tttcaatttt atccgctgct 2508121 gttttggcaa ccgttttcag ctcgtccttt tcaagctcgc ggaaaaaaac ctccaaacag 2508181 cgggaccgga tagctggcgg aatttcgttt ggcattctcg tggtcgcgcc aatcaagcga 2508241 aaatcagccg gcagcccatt ttgaaaaata tcatgaatat gattcggaat ttgtgtattt 2508301 tcctcactgt aatacgcact gtctaaaaag acttttctgt cctcaagcac cttcagcatt 2508361 ttattcattt gaataggatg cagctcccct atttcatcaa taaacagcac accgccatgg 2508421 gcatgggtga cagctccctg cttcggctgc ggaatcccag cctgtcccat cgctccggcc 2508481 ccttggtata tcgggtcatg gacagagccg atgagcggat cggcaattcc tctttcatca 2508541 aaacgggctg ttgtcgcatc gagttccaca aagacagcct gctctttaaa cggtgattgt 2508601 ttatgttttt ttgcttcttc caacacaagc cgcgcagcag ccgttttccc aactcccggt 2508661 ggcccataga caatcacatg ctgaggattt ggcccgcata aagccgcctt taatgcttta 2508721 atgccgtctt cctgtccgac gatatcttta aagcttttgg ggcggacctt ctcagataat 2508781 ggctcggaca agctgatagc gcgcattttc cgaagctgct ccatttcctt ctttgattct 2508841 ttatctatcg tgaccttttg tgtcctttga tttttaagca aattccaaaa atacaaaccg 2508901 atgatgatcc caaaaaacag ctgaataaat aacgcgatcc ctgtccaact catggtggtc 2508961 cctcctgaaa aacaatttat gtatccaatt cattcctctg attgctagta tctcccatag 2509021 aagacgggaa taaacgtttt tccggaagag ttgcatgcaa aaaaacctcc tgagtgttac 2509081 cactcaggag gtttgtgctt atctttatgc agatgtttta tcttggctta cctcagtgcc 2509141 gtcttttaat aagaggcgag gaggctctcc gtgtgtcaca gttgccccgg tgattacaca 2509201 tttttcaatg tcatcacgag aaggcagctc aaacatcaca tcaagcatga tgccttcaat 2509261 gatagaacgg agtccgcgtg ctccagtctt gcgttcaatt gcttttttag caatttcaga 2509321 aagcgcttct tcttcaaact caagctcaac gttgtcaagc tcaagcattt tcttgaattg 2509381 cttaacaaga gcgtttttcg gttttgttaa gatcgcaacc aatgcttctt cgtcaagctt 2509441 ttcaaggctt gcaataaccg gaagacgtcc gataaattca ggaattaacc cgaaacggag 2509501 caaatcttct ggaagcactt ttgaaagaag atcttctttc tcaagatcag cagctttatt 2509561 gtcggcaccg aatccaatca ctttttggcc taaacggcgt ttgatgattt gttcgatacc 2509621 atcgaaagct ccgccgcaaa tgaacaaaat atttgttgtg tcaatttgaa tgaattcttg 2509681 atgaggatgc ttacgtccac cttgaggcgg tacgcttgcc actgtaccct caagaatttt 2509741 aagcaatgcc tgctgtacac cctcacctga cacatcacgt gtgatagacg ggttttcaga 2509801 ttttctagcc actttatcga tttcatcaat atagataatg cctttttcgg ctttttccac 2509861 atcataatca gcagcttgga tgagcttcaa gagaatattc tctacatctt cacccacgta 2509921 tccagcttca gtcaaagatg tagcgtccgc aatcgcaaac ggcacattta aaatgcgagc 2509981 caatgtttgc gccagaaggg ttttaccgct tcccgtaggg ccgattaatg aaatattact 2510041 ttttgaaagc tcaacatcat caactttgct gttggagtta atgcgcttat agtggttata 2510101 cacagcaaca gcaagtgatt tcttcgcttg atcttggccg atgacatatt cattcaaaat 2510161 ttcgcgaatt tcctgaggct ttggtacgtc tttaaattct acttcttctt ctgttccgag 2510221 ttcttcctct acaatttcag tgcagagttc gatacattcg tcacatatat atacaccagg 2510281 tccagctaca agcttacgaa cctgatcttg tgtttttcca cagaacgagc attttaattg 2510341 tcctttttcc tcgttaaatt taaacattct ttcacccctt aatcttgtct cactttttct 2510401 tttaccggca gagcaaaaga aaatgattct tgaaacgaac gagtatgtat tgcattttac 2510461 catactttcc aaaaagacgg taacaatgtg tttctgactt gcacattcta tatgtatgac 2510521 aaaaaacagc cctgcattaa ctatattgcc ccaagaaaaa gagataactc ataattgtac 2510581 aaaacaaggc acgaatgatt cgcgccctgt tttattagta ctattattat gcaccatatt 2510641 aacggttttc tacaagaaaa tcaattgctt tgcgaacttt taaatcttct ttcatcgcgt 2510701 cagtagaacc gatggcttgt ttaatatttt caacaggcat gttgtatgct tcagccattt 2510761 ttgtaagctc agcatcaact tcctcatctg atacttcaag gttttccgct ttcgcaatcg 2510821 cctcaagagt caggttagat tttacgcgtt tttcagcatc ttctttcatt tgctctttaa 2510881 gcgcagcttc atcttggcct gagaattgag tgtaaagctc aaggttcatg ccttgcattt 2510941 gcagacgctg ttcgaattct ttcagcatgc ggtcaagctc agtgtcgacc attgcttgag 2511001 gcacatcgat ttcagcattt tcagaagctt tcagaacaag ctcttcacgc aatttagcgt 2511061 cagcttcgtt ttcttttgct tcttctaaac gtttctttgt tttttcagtt aattcagcaa 2511121 gtgtttccac ttcttcatcg atatcttttg cgaattcatc gtcaagctca ggaagctctt 2511181 tcgctttgat ttcgtgaatt ttcactttaa acacagctgg tttgcctgca agatcttcag 2511241 cgtggtactc ctcagggaat gtcacttcaa catccttctc agcacctgct tcaaggccaa 2511301 ctaattgatc ttcgaagcca gggatgaatg aaccagaacc tacttctaga gagtagtttt 2511361 cagcttttcc gccttcgaaa gcttcgccgt caacgaatcc ttcgaaatca agaacaactg 2511421 tgtttccttc ttcaacggcg ccttcttctt ttacaacaag ctcagcttga cgctcttgaa 2511481 gggcttttag ttcgttttga acatcttcgt cagttacagt tgtgtcgtct ttttcaatgc 2511541 ccaggccttt gtattcgcca agcttcactt caggttttac tgttactttc gcagtgaaga 2511601 ttaagctttc gcctttttcg attttttcaa catcgatttc aggacggtct acaggctcga 2511661 ttccagcttc ttcaaccgct ttagggtatt ctacaggaag aagaatatcc aaagcatctt 2511721 ggtaaagagc ttctacgcca aagcgctgtt cgaataatcc gcgaggaatt ttacctttac 2511781 ggaatccagg aattgaaact tgttttacta cttttttaaa tgcatcatca agtgctgttt 2511841 taaacgtttc agcatcaact tcaaccgtta aaacgccttc gttgccttct tgtttttccc 2511901 attttacaga catgtgtttc cctccaaaaa tctattcagg ttgtgtcggt cttccattct 2511961 aaagcaatca ttcggcttcg tccaacaaaa acaaagctgc caaagatcag aatcattatg 2512021 tatagatgtt aataatgaac tgcaaagcct gtccaaccgt atttcttata acccgttata 2512081 cacaaataca accactatat tataacataa cacatagcgc tttcaactat atggcgcgat 2512141 ttacaaataa gaaatttctt caatatcttt taacattgtg caagcttcat cgagttctct 2512201 gtctgtaaat tcatacatca tatgaagttc ttcgctttca atttcaatcc cgtgcatctc 2512261 gtaaccgact ttatgaaggg cagccgccca aaggtcagcc gacagcaatt tcggctggaa 2512321 cggatataaa acgtacaaat gtcttctcca caattcttct actgctgcat ataaggttgg 2512381 attttcattt ccaagtgtct catctagcac cctgagaaca cggtgaagaa tcggcgcggc 2512441 atcaggcgga acaatctctg acggttcaat tgtcaacgac tcgccaaatt tactaatgtg 2512501 tacaggttta ctgtactcat gctcagccaa cagcatgaca atcatcgttt tgataatcgg 2512561 atgggctgag gggtcttgga ggattgtttt gagcaatcct gtatactttg ctacgttacg 2512621 gtcttttaag gaatgaatga gattcatttg ctcctcaggg cttgccagca ctttctcggt 2512681 gtcaattgta tcctcatatt cttcggccca agcctcgtcc tcacgatccg gatcggtcat 2512741 tttccggctg aaatccagca gcttataaaa ttgctcggca ctttctgccg gcagctgatt 2512801 ttcttccaaa acggcttcaa tggtgctttt gacttcttcg tactttttga gctgaattaa 2512861 gatggtcatg tacacctgca aaaccgtaaa ataatggcca taaccttctt tgagcatctt 2512921 ctcgcacacg ctttctgcct cttccagctc gcccagctct aaaaagcaga tggccatccc 2512981 taagtgaaga tcggattcag tatcatcata tttcatcgct tctgaaaaca gttcaagcgc 2513041 ttcttgatac tttttttcct tgagtgatga catccctttt tccacaaggc ggtctttcag 2513101 atgaggaaaa ggaataattt ttgcgttttt cttgtcatgc gtcataccta tattcctttc 2513161 aggcatttat tttgttcaag tgtatcaaca cctgtgaaca aaaacaagaa atgaaaggtt 2513221 tcaccaggca aaaaaagccg ccggacaaat accggccgct ttttcaggct tgaagccaag 2513281 agcttctttg tgattcaaat tgcttgattt catcttccag cagcagcgtt aatgaaattt 2513341 catcatatcc gttgatcagc atctctttcc aatgcggatc aacttcaaat gaaatttgat 2513401 tgccttcact gtcatgaatc agctgatttt caaggtcaac agtcatttgc aatgactggt 2513461 tttcatactg gccgacaagc tgtttccaat tgtcatatgg catgcggatc ggaagcatgc 2513521 cgtttttaaa gcagttctga tggaaaatat cagcgaatga cggcgcaatg ataattttaa 2513581 acccataatc atcaagtgcc cacggagcgt gttcacgcga tgacccgcag ccgaagtttt 2513641 ctcctgctat taaaatggaa gctccttgat aaacaggctg gtttaattca aattcagggt 2513701 tcggttcacc attcgcatca tatctccagt caaagaatgc aaaacgtccg tagcctgttc 2513761 tttcaatcct cttcaaaaat tgcttaggaa taatctggtc tgtatccaca ttgatccgat 2513821 ttaatacggc tgctttcccc gtatgtgatt tcaaaggttc catctcgcgc actccttaca 2513881 caactgtttt ttcctgataa aactttctga catcaacgaa gtgtccgtga atggcagcca 2513941 tcgcagccat tgccgggctg acgagatgtg ttcttgcacc ttttccttgt ctgccctcga 2514001 agttgcggtt agaggttgat gcacagcgct ctccctcagg aacaacatca ttattcatac 2514061 tcaaacacat gctgcagcct gactctctcc attcaaatcc agcttccaag aaaatctggt 2514121 caagcccttc tttttcagcc tgaagcttca cgctttggga tccgggcacg acgatggccc 2514181 ttacgctgtc agctaccttc ttccctttga tcatgtcagc agcctgtcga aggtcagtca 2514241 tgcgggaatt tgtgcaggaa ccgataaata cgtgctccac tttaatgtct tcaatttttt 2514301 ggtgaggagt caatcccata tattcataag cacgaatcgc ttctttttta tcgtcttctg 2514361 cagaaaagct ttccggcgca ggaacttcag aatcgacagg aagaaccatt cccgggttaa 2514421 tgccccatgt caccataggg gaaattttgt tgccgtcaag gacgatagat ttatcgtaaa 2514481 cagcgcccgg gtctgtgcgc agcgccttcc attcctctac ggccttgtca aattcttcgc 2514541 cttttggcgt gtacttgcga tttttgcaat attcaaacgt cacctcgtca ggtgcaatca 2514601 aacctgctct tgctcctgct tcaattgaca tgttacaaac agtcattcgt tcatccatcg 2514661 tcatatttct gaatacttcc ccagtgtatt caatgacgta gcctgtgccg aatttcacac 2514721 cgtatttgcc gatgacagca aggatgacat cctttgccgt tacccctttt tgaagcgttc 2514781 catctacgcg cacttcaagt gtttttggac gctgctgcca aagtgtctgt gtggaaagga 2514841 catgttcaac ttcactcgtc ccgattccaa atgcaagagc gccgaaagcg ccatgtgttg 2514901 atgtatgact gtcaccgcac acaatcgttt tccctggaag cgttaagcct agttcaggtc 2514961 cgacgacatg gacaatccct tgatccacac tgtgaagatc ggcaaggcgc acgccaaatt 2515021 cctcacagtt tctttcaagc gccgttacct ggcgtttcgc aacttcatcc tttatctcaa 2515081 aacgattgac agtcgggatg ttgtggtcca ttgtcgcaaa tgtgttttgg ggtcttctga 2515141 cctttcttcc cttttgtctc aagccttcaa atgcctgagg agacgtcacc tcatgaatga 2515201 ggtgcaaatc aatatagaga agatccggct ttccctcacc atgttttaca atatgctgat 2515261 cccaaatctt ttcgatgatt gttcgaggca tcatctttta tttcctccct ctacctagag 2515321 ctaagaccgc ttaacgtaag ctgtcacaca ttagaaattg tattttcact catgattgct 2515381 gccttaactt cctctgtaat ggcctgagtg ctgctgaact cttcactccg tgccaagtct 2515441 cttgttcttt ttccagaagc caagactttg tttaccgcat cttctacagc tttcgcttcc 2515501 tcttcaagcc cgaaagatgt tctcaaaagc attgccgctg acaatatggc tgcgaacgga 2515561 tttgccatcc ctttaccggc aatatcaggc gcggagccat gaacaggttc aaacagatga 2515621 aggccagagc ttgataggct ggctgacggg agcattccga gcgagcctgt aagcatggac 2515681 gcttcatcgc ttaaaatatc accgaacata ttttcagtca ccacgacatc aaattgattc 2515741 ggtgcataaa ttagctgcat ggccgcgtta tccacaagca tgtgctcaag cttcacatca 2515801 ggaaattctt gtgcaacgtc ctcagccact tcacgccaca gccggcttga ttcaagaaca 2515861 ttcgctttat ctacagaggt cactttgcct tttctggctg ccgccatttt gaagccctct 2515921 ctgatcactc gttcaatttc cgttcgctta taaaacagtg tatctactgc ttcctgctca 2515981 ccttcagtgt ttacataacg tttgctcggc tggccgaaat acaagccgcc tgtgagctca 2516041 cgaacgataa cgaaatcaac attatctata tattcttttt tcaaaggcga agcgtcagaa 2516101 aggctttcaa ataccttcac aggccgcaaa ttcgcaaaca aatcaagctg ttttctgatg 2516161 ctgagcagcc ctttttccgg tctcagttcc gaaggatttt gatcccattt cggtccgccg 2516221 acagcaccaa gcaatatcgc gtctgcattt ttacaagcag caacggtttc ctccgggagg 2516281 gggttatgat gttcatcaat agccgcccct ccaatcaggc catattcaaa ttcaaattca 2516341 tggttaaagc gttcggcaac acttttcagt acgtctgtcg ctgattctaa tacttcaggg 2516401 ccgatcccgt ctccgggcaa tagagcaata cgtttcttca agttaaccgt tctcctttct 2516461 tttatgatcc gacagctgtg tggtttttca atccgctcat attcgactgg aaaaccaatt 2516521 gacggtttac tgcgttcaaa taggctttcg ctgatgcttc taatacgtct tgcgctatgc 2516581 cccgccctgc tgattctttt ccgttcacca aaactcttac atacacctgg gcaaatgcat 2516641 cttcgccttt tctattagac tgaatgcggt agtctaagag ctccacatcc ttatcgatgc 2516701 agcgctcaag cgtattgtag attgcttcca cgcttccagc tccagttgca gcttcctgaa 2516761 taagctgtgc gttttcttga tttttcaaag atagagtagc cgtagggacc tgacttgttc 2516821 cgtaatgtac ttgcagagaa agaaattcat acccaatctt gcgatctgtt actttttctt 2516881 ctaaaataag agaaacaaga tcctcatcag tgatttcttt tttcttctca gtcaactctt 2516941 tgaacatcgt aaagaattta ttaatctctt cactgtcaaa ttggaatcct aaagcagtca 2517001 gccggtcttt aaatgcgtgg cgtccggaat gtttacctag gacaagcgca tctgcggtta 2517061 cgccgacaag ctccggtgaa ataatttcat aagtcgattt ttcctttaaa aagccgtcct 2517121 gatggatgcc tgattcatga gcaaatgcat tatctccaac aaccgctttg ttgcgcggga 2517181 cagccatgcc tgtcagtttg cttactaaat cacttgttct cttaatctcg ttcagcgtaa 2517241 tacctgtttc gacttggtag aaatcttttc tggtatggag ggctacggca atttcctcta 2517301 atgccgcgtt tccggctctt tcaccgatcc cgttcacagc gcattcgatt tgatcagcgc 2517361 cattttcaat cgcagcaaga gagtttgcga ctgccattcc caaatcatca tgacagtggg 2517421 ctgaaagctt tgctttgtga atgttcggaa cgttttcttt catatattta aagatatttc 2517481 cgtattccgc cggggccagg tagccgacag tgtccggaag attgataaca ctggcgcctg 2517541 cgtcaatcac tttctcgacg atttctgcta gaaacggcag ttcagtgcgg caggcatctt 2517601 cagctgacca ttgcacaatc ggaaaacgtt cttttgcgta tttcaccatt ccaactgctc 2517661 tttcaatgac ttgttcacgt gtcattttca gcttgtgctt caaatgaatg tccgatgtcg 2517721 cgataaatac atgaattctt ggttgagcgc catcctttaa cgcttcccaa gcagcatcaa 2517781 tatcaccttt tacacaacgg gccagaccag ttactgaaca atttttaatg gttcttgcga 2517841 tttcctgaac agctaaaaag tcacctcggg acgaagcggg aaatcccgct tcaatgatgt 2517901 ctgccccgag tctttcgagc tgcttagcta tggcaagttt ctcctgtgta ttcaagttca 2517961 ctccagggga ctgttcacca tcacgaagcg tcgtatcgaa aaaattaatt ttgcgcaacg 2518021 gagaccaccg cttccttctt cttgccttgt ttcacaaacg gcatcatttc acgaagcttt 2518081 cttcccacta cttcgatttg atgttcgttc tcgcttgcat tgatagcgtt gaaacgagga 2518141 cggtttactt ggttttcgac gatccactct tttgcgaatg taccgttttg gatatctttt 2518201 aatacttctt tcatagattc ttttactttg gcgtccacaa cgcgagggcc tgatacgaaa 2518261 tctccccact gtgctgtgtc agagattgaa tatctcattc ctgcaagtcc ttcttcgtac 2518321 ataaggtcta cgattaattt cagctcatga agacactcga agtatgcaag ttcaggctga 2518381 taacctgctt cagttaaggt ttcaaatccg gctttgacaa gcgcgcttaa tccgccgcaa 2518441 agaactgctt gctcaccgaa caaatctgtt tctgtttctt ctttaaatgt cgtttctaat 2518501 acgcccgctc ttgcgccgcc gattccttta gcataagcga gggctttgtc tcttgcttct 2518561 ccagtcacat cttgatagat tgcgaacaat gcaggtacgc cagctccttg ctcatatgtt 2518621 cttcttacca agtgtcccgg gcctttaggg gccactaaga atacatctac atccgccgga 2518681 ggaacaattt gatggaaatg cacgttaaat ccatgagcga atactaatga ttttcctgct 2518741 gtcaattcat ctttgatttc agcttcgtat actttttgct gctgctcatc cggaagcaga 2518801 accatgatga tttcggcttg ggctgccgct tcttttactg aaaatacttt atgtccgtct 2518861 tcttgggctt gagtgaaaga ttttccttgt ctaacaccga cgatcacgtc tactccgctt 2518921 tctttaaggt tcagggcatg tgcgtggcct tgcgaaccgt acccgataac cgctactgtt 2518981 tttccagcca atacgttctc tttgatatca ccgttataat atacttttac catttcaatc 2519041 tctcccttgt tatgttttat acaatagata ttgttttatt ggatgacgcc ttttgctggg 2519101 ttcccctcgc aaaagccgtt gtacctgttc tcgcgatttc tttaatgcca taaggtttta 2519161 ataactcaat aagcgcttca attttgttag attcacctgt cacctgaaca acgatgctgt 2519221 ctctgctgac atcaacgaca gaggctctaa acggttctat gattccatta atctctgttc 2519281 ttgttgaagg tgcggagaca accttgatta aggccagctc cctctggaca atcgattgat 2519341 ttgtgatgtc tgtgactttc agcacatcaa tctgtttgtt gagctgtttc gttaactgtt 2519401 caacatcatt ttcaccttca acatgaacga cgaaggtgat tctggaaacg ccggctgttt 2519461 ctgtgtgtcc aactgtaatg ctttcaatgt tgtaatgcct ttttgtgaat agaccggtga 2519521 tccggtttaa caccccggag cggttcacca cagtcaatgt gataattctt ttcaaggttt 2519581 cacccccacc atttcatgca gccctttccc cggagccacc atcgggaata ctttttcttc 2519641 gctggcaacc cgcacgtcaa tgacaacagg ttctcttgat gttaatgcct cttccagctt 2519701 ttcctttgct tccgcttctg atgaaattct gatgccttta atgccgtatg cttcggacaa 2519761 tttgacgaag tcaggctgag aagcgaattt agattctgaa taacgttctt catagaaaat 2519821 ttcctgccac tgtctgacca ttccgagaca agcgttattt aaaatcacta ccttgaccgg 2519881 aagatttaat tcgcgaataa catcgagttc ttgaagcgtc atttggaatc cgccgtctcc 2519941 gacaaccgcg acaacagtag catctttttc ggccagctgt gcgccgatcg ccgccggaag 2520001 accgaatccc atcgttccaa gtccgcctga cgtgacccat ttatctgctt tttggaacgg 2520061 ataaaattgc gctgaccaca tttgatgctg gcctacatcc gttgcgacaa tggcctctcc 2520121 ttttgtaaat tgatgaatat attcaatcaa tttctgaggt ttaaaacctt cttcttcatt 2520181 atctacatac cagagcggat actcttcttt ccattctgcg agctgttttt tccattcgct 2520241 tgaatcgctt tgtttgccgt cttgtttgat cagctcctgc aggacaattt tgctgtctcc 2520301 gactacagga atctgtgttt tcatgatttt tccgatttca gctggatcaa tatcgatgtg 2520361 ggctatcttt gcgtttctgg caaagtgttt caggtttcct gtgacacggt catcaaaacg 2520421 ggcgccgata ctgattaata gatcacattc atgaagggcc atattggctg tataagtacc 2520481 gtgcattccc gccatcccta ggaaaagcgg atggtcagcc gggaagcctc cgagccccaa 2520541 aagggtgtgt gccacaggga tttgctgctg ttcagcataa ttttttaatt cttctgacgc 2520601 ttttccgtgc agtacgcccg cacccgccag gatcaccggt tttttcgcac tgctcacggc 2520661 ttccacaagc ttgcggatct gcaaataatt cggctctgtt gtcggctggt atcccgggag 2520721 attcatctca tgatcgtagc tgaattctcc ttcaattgtt gctacatctt tcggaatatc 2520781 aatcaataca ggtccgggtc ttccagttgt tgcaatatgg aacgcttctt taatgatgcg 2520841 cggcagatct tccggctggc gaacctggta gctgtgtttt gttactggca tcgtaatccc 2520901 taaaatgtct gcttcctgaa atgcatcgct cccgattaca gaggttgcta cctgccctgt 2520961 aaagacgact aacggcaatg aatcaatcat ggcatcagca aggcctgtaa caaggtttgt 2521021 cgctcccggc cctgacgtgg caatgacgac acccggtttt ccggagaccc ttgcgtatcc 2521081 ctccgctgca tgaattgctc cttgttcgtg acggggaagg atatgtacca accctgaatt 2521141 gtatagctta tcgtaaatcg gaagcacagc cccgcccgga taaccgaaga tcatttctac 2521201 tttctctttt tttaatgatt caatcagcat taatgctccg ctcatcgtct gtgtacattc 2521261 ggcagatgct gaatccacct gtacattagt ccccatttta gttcctcctt ttggattttc 2521321 atcctttaaa gatcatcttt tcattagcta gatagctgat tattcaataa aaaaagccct 2521381 tccgcccaca atcagccgcg cagtaactgc gatagctaaa aggggcgaaa aggcttttct 2521441 ttccgcggta ccacccttgt ttacggcctg ttaatcggcc gtctcatgga tatttctatc 2521501 cgctttagta acgagtgaat caagttcacc cggccaagtc ctactgtcat ttcagactgg 2521561 cactctgagg cgagttcacc ttgtaaagct tcgccggttc tcagctaacc cggttctctg 2521621 tggaaaactt tatcaaggct acttatcctc atctgcgctt ttcatattca gccttcggaa 2521681 cggctttcca gctgttcaag aaggtcgttt gtttttcatt tttttagaat catactgcga 2521741 tgattttcgc ttgtgaagct tgcatttatc ttttgttgaa ctcatattac gccgctttgg 2521801 acgcagtgtc aacagcattt tttaaaatta ttagacaatt ttgattaatc aatctatatt 2521861 gtatacgctt tcattattgg tacaaaagga attgcaaatg ttaaaagttt ttataatttt 2521921 tttattaatc tatcaagaat acaccagaat tatttaattt tatataaaca tggaagattt 2521981 tataacacga tatggttcgt atatggattg agtctgacag atcatcttgc aatccatttc 2522041 aatttcggat aggcacttct cttgttccct cggcatacat taatgatatc ttgcaaagaa 2522101 aaggtgatac gatgaataaa tcatttgcag acatgcaagg atttcctgcg ggctttccaa 2522161 gcttccccaa ctttccgcag cagtactatc ctgctgtccc tcccttttac cagcaaagcc 2522221 agcagccatt tggaggctac ggatacggac agccgttcag tcaggcatac agcccgttaa 2522281 ccactccctc tggaatgtac tcctcattcc catacgcttc aggattttac ggacagcaat 2522341 tttcaggtgc aggctttagc ggccatggcg gcagcttaag tgctccagcg atacatgccg 2522401 gcggattcag cggggcgcca ggcgtacacg gaggctttag atattaaaga ataccacaag 2522461 ggccgaacat ctattgcggt ccttttattg ttttaaaacg acttcacaag tacagtcaca 2522521 ttttctgtct ttatatttgg aaacaggatg gaatatgatt aagatgaatt gaacgatatt 2522581 ctgcacaatc cgtaagtttt cgaggaggaa taaaattgca tataaaaata gacgatttaa 2522641 ctggacgtca ggtggtttca ctggtgaatg agcatttaca tagcatgacg cttatgtccc 2522701 cgccagaaag cattcatgcc ttaggtctag aaaaactaag agggcctgaa ataacatttt 2522761 ggagcgcatg ggaaggtgat gaactagctg gctgcggagc gctaaaagaa ctggacaccc 2522821 ggcatggaga aatcaaatca atgcgaacat ctgcatcaca tttaagaaaa ggcgttgcca 2522881 aacaagttct ccagcacatc attgaagaag ccgagaagcg aggctatgag cggttaagct 2522941 tagaaacggg ttcaatggct tcatttgagc cggcaagaaa attgtatgaa agcttcggtt 2523001 tccagtattg tgaaccgttt gcagactacg gtgaagatcc aaacagtgtg tttatgacga 2523061 agaaattgtg agacggcttt ataaggatag ataagtgcag gggaaggtct gtcttatcta 2523121 tcttttttta tattcacaca tttttcacct ttatgataca cgccaatgtt ttcaattttg 2523181 tttaattcaa agaacagcgg gaattacaaa cgacatgaac gatatcatgc aaattcataa 2523241 aggaggagat tgatatgaaa agcatagttg gtgtatatga aactccgcag gaaaccatcg 2523301 cagcgattga aggcttactt acaaaaggct atgattctga tgacatttct gttgtgacaa 2523361 gccggcgaga tacagattat ttggagtcac gtacaggaac agaagtcaat caagctatcg 2523421 atgcacatca ggacgaatct gaatcttttt tcgataaact gaaagattat ttcacaatgg 2523481 atgatactgc tacacacagc aaagcattat ccgacttgga tattaaaact gatgaaatag 2523541 acaagtatca agaagatttg gatgacggaa aacttctggt agccgtcgat acagatgcag 2523601 atgtaattgc tcctattgat aacggcaatg ccctttcagg cggcttttca agcacaaatg 2523661 aattggatta tacaacgaaa gaagaaaaaa cgatgccgct ccgggaagaa cagctgaagg 2523721 tcgataagga agacgttcaa accggcgaag tagaaatagg aaaagaagtg aaaacagaaa 2523781 aaagagatat ggacattccg gtgagacatg atgaaattta tgtcgaacgc cgtccagtgg 2523841 atgaaaataa aacggacgct gctcccgtca acgattcgga agagatcaga gttccaatcg 2523901 ttgaggaaaa gctggaagtg actaaaaaac cggttgtcac tgatgaagtg gttgtcggca 2523961 aacgcactgt tgaagaaaat gaacatattt ctgaaactgt gaaaaaagaa gaacctcgtc 2524021 tgaataaaga aggaaaagtt gacggcttgg atgatgatcc gttaaataac aaatgaaaat 2524081 catagaccga caacaaaaaa cctcaaatcc taaatggatt tgaggttttt cttttggtac 2524141 gtcccaggag agattcgaac tcccgaccga cggcttagaa ggccgttgct ctatccagct 2524201 gagctactgg gacacgtttt gtttttttgt ttttcgcttt aactatcagc gacaagattt 2524261 attatatatg ggatgcaata ataagtcaac ggttttttag aatttttttc atgaggaaga 2524321 aaattttctt cctcatgaca ttttcatagt gtgactcgat tttgcagatc ctcaatttca 2524381 ttgcctgctt ggtcgtaaaa acggactgtc gcagcatcat tttctaatgt cagtatagca 2524441 tagctttctg tcctgcgcac cctcggaagc cggatgctgc ctgggttaat catcagtttt 2524501 ccgcgcagca cttcgcttcc cgcgatgtgc gaatgcccga agcagataac atccgccccg 2524561 agctcctctg cacgatagta tacgtttaac aaggtctgtt ttataccgtg aaggtggccg 2524621 tgtgtgacta gtatttttct tgagccggca gtcagaagaa gctcgtcctt aaaatcgccg 2524681 gcaaaatcgc aattgccttt tacaaccgca taaggctcca atgcaggatg cctcgtctca 2524741 agctcagagt ccccgcaatg aatcatgaga tcaacttctg cctcatgccg tttcgcaatg 2524801 gtttggagtt cttcttcaag cccatggctg tcactgataa tcagcacgtt catgtacaag 2524861 cttcctcctt atgcctccaa aagcttagac agctttttaa gcgcgtcagc cctatggctg 2524921 attttatttt tttcatcact tgtcagttca gccatcgtct tatctttatc tttcacgata 2524981 aaaattgggt catagccaaa gccatattct cctctcggtt cttcagcaat atacccttca 2525041 acatggcctt cgactgtttt tgtttcctct ccgggaatac tcacggccag tgcgcagcgg 2525101 aaacgggcgg tgcgctgttc tttttcgata cctttcagct cgctgagcac tttttcgata 2525161 tttgcctggt cgtctttctg ttcccctgca tagcgggctg aataaacccc gggtctgccg 2525221 ccaagattat cgatggatag tccggagtca tccgcaatca ccattttgtt cactgctttg 2525281 gcaacagctt ccgctttcat aatggcattt tcttcaaatg tatggcctgt ttcttcaatt 2525341 tcctctgtga atccaatttc agctaaagat ttgacatcat agcctcttgg ctcaagaatt 2525401 tctttgaatt ccttcacttt tcccggatta tgtgttgcaa taattgcttc tttcatgatg 2525461 atcaagcctt tctgtcttta tttcagttct ggcagagaat cacccagcac ttctttttgc 2525521 ttgtcaatca gctcttggat tcctttttcc gcaagaccca gaagaccgtt cagatcctct 2525581 ctagaaaaag ttgcctcttc cccggttccc tgcaattcca caaaacggcc gctgcctgtc 2525641 atgatgacat tcatgtcaac ttcagcagag gaatcttctt cataatttaa atctaacaaa 2525701 attccctgtt ccttatcaat tccaacagag attgcagcaa gaaaatcagt gatcggattt 2525761 gtcttgattg ttcctgcttt gatcagcttg ccaatcgcaa tcgccatagc aagaaatgcg 2525821 cctgtaatgg aagctgttct agttcctcca tcagcttgaa tgacatcaca gtcaatccaa 2525881 atcgtccgtt caccgagctt ttccagatct acaacagctc gaagcgcgcg gccgatcagg 2525941 cgttggatct ccattgttct gccggaaatt ttccccttag aagattctct gattgttctt 2526001 tggtttgttg cccgcggcag catgctgtac tctgctgtaa tccagccttt ccctccgccc 2526061 cgcaaaaacg gcggtacgcg gtcctcaaca gacgcgttgc agattacctt tgtatttccc 2526121 gctgttatta gaacagaacc ttccggatgg ctgataaaat ccaaatcgaa tgtgattgga 2526181 cgcagctcat cgtgttgtct tccgtcatgt ctcatgtttt acctccgatt gtatgtacat 2526241 aaaccatttt tgtcccggaa ttgaataaag aaagaggcag ccggaacgct aacctctttc 2526301 ttcctagtat atcaaaaatc ccaatttaaa aactacccgt attcacttga gatggtctgg 2526361 agaccggttc tgtgagcttt tcgccttttt catttaccag ctctgatttt ccgttcactt 2526421 taacagagac gctttttaca tccggctgct ccgttaacgt cagcacaatg ctgttcagca 2526481 cttctgaaga aatcattttc gtcttctcat cggcgctgcc gaatatagat tgattgaaat 2526541 ccaacgtcac gcgcccgtct ttgattttcg gtttgctgac cagctttaca tcttcactga 2526601 agtctgttaa cagcccgctc accttgctcg gccctttagc caattcatta atggctgctg 2526661 tgatgtcgtc tttttccgaa ttgtcgattc gtttggtcac cggcacgtag tattcactgt 2526721 cttcattttc cgccaaatag tagactgtca gcggatgggt agcagtgaga tcatttacac 2526781 cggctgtttc caaattaatg ccgtctttgc ggcttaaatc atctgagatc ggcgtccctc 2526841 ctacaggcat ctccttcagt tcatgcccgt ttattctcag cttcacttta tctatcgaac 2526901 taaattgcgt cagcgtccac gtcacagatt gaacgatttt ctgttcgtct tctttcttat 2526961 aatttttgaa ctcattagag aaatcagcta tcgccgttcc atcttttttg atgtcaacgt 2527021 taacggtggt gtcagccggc aatacagctc tgaagccatt cggaagaatt tcagacacag 2527081 gcccgccctg tacgaggtat tcaagcgcct gcttagccgt gctctcactt ttaggaagag 2527141 gcagcgtttg cgcaacaaca tacccgtttt tatcaatgag ataaagctcc ctcataacag 2527201 tagatgaggc ttgatccgct tttgcggtat cgcttttttc actttctgtt tttttggctg 2527261 ctgttgtatt tgaattggca cccgcttcat cgttcacgaa tgtaacgtct tgaggcggat 2527321 caatttcctc ggctgcctta tcagattgaa acaaaccgca tccggataaa agcaaggcag 2527381 aggtgagaca agtggcacca atgactgcag gtcctttttt cagcatactt ttccctccta 2527441 aggatgtttg tactattatg tatacgagcc tctttaggaa atagaccgaa gaattccggc 2527501 aaaacagaaa aaaacccgca acataccgtt gcggggaaaa ctatctttta atcggttctt 2527561 gcagtgagat acattccaca tgcccgactt catggccaaa ccaatcgtct gcgatttttg 2527621 caaactgatc acgcgcccct gttgtcagga actgatgatc cggggcaatc ggagactggt 2527681 tcagcagccc tttataagag agaattgtgc tgacttcccg ggctgtttca tcgccggacg 2527741 aaataatgtt tacgtgctct cccatatatc tttgaatggc ttcttttaaa atagggtaat 2527801 gggtgcagcc taaaatcagc gaatcaattg atgtgtcttt taacggatac agcgaggttt 2527861 taacaatctc gtctgctgtt ttgtcgagaa acttcccgct ttccacaaaa ggcacaagca 2527921 gcgggcaggc aaggttttca accttcaaat cagggtttaa tgccaaaagc gcttcttcgt 2527981 atgcattgct cttaatcgta ttctctgtgc cgatgacacc gatatgctga ttatccgtca 2528041 cttttatcgc tgctctcgca ccaggctgga tgactccgac caccggtata ccgacgctgc 2528101 gctggatgtc atccaaagcg atcgctgttg ctgtattaca ggcgatcacg agcattttga 2528161 tgtggtggtt ttcgagtaaa taattcgtca gctcccacgt atattgaagc acctcttctt 2528221 cagggcgcgg cccgtaagga caccgtttcg tatccccgac gtagataata ttttctttag 2528281 gtagctgtct catgatttcc ttcgcaacgg ttaaaccgcc aaccccggaa tcaatgactc 2528341 ctattggttg ttccaacaaa atcgcctcat tttctcttca tttcatgctg cagtttcatc 2528401 aaagattttt cgaagatggc tatttcttca tctgtaaacg attcgaacat atcacgcaga 2528461 tattcctgtc tttttgtaat gacctcttgg ataatccgtt ctccttcagg cagcagatgt 2528521 atcctgacaa cacgtctgtc cgccgggtcc ttgacccgct caacaagctc atttttttgc 2528581 atgcggtcga ttaagtccgt tgtcgtgctg catgccagat acattttgcc cgataattca 2528641 ccgattgtca tatctcctaa ttcataaagc cattgcaagc cgacaaattg cggcggcgta 2528701 atcgcatatt ggttaaggat ttctcgtcct ttttgcttaa tgatcgcggc aatgtggcgg 2528761 agtgactttt caatatccgc aacatgctcc aaaggttttg atgtcatttg tccatccctc 2528821 actcaaggat ctcttacgca caaaagcgtt ccgtgtctat tttccttctt ttttgaagaa 2528881 aatgcaagac tcgcaggaga gaaatagagg actttagtca aacaacatca agaaataaaa 2528941 tttaatttat gacttgccta cgttttgcac agcattccaa atatggtttc gaatgttcca 2529001 aacaaacagc aataaccggc tccttccaaa agaaggaata ccggcaagga ttaaagctct 2529061 agctcaccca ttctaagaag ctcaacaacg gcttgcgaac gccctttcac acccaatttc 2529121 tgcatggcat ttgaaatatg gtttcgaacg gttttctcac tgataaatag ctcgcttgca 2529181 atctcctttg ttgtcttatc ttgaacgagc aattcgaaca cttctctttc tcttttcgtt 2529241 agcagcggct tcgattgaaa ttctttctcc ttcaagtatt gtaaccctcc ttgctaaggt 2529301 gagagcgaat cagaaacgaa tgggttttga tatagtcgag atatcatatg taagaagggc 2529361 gcaggaggtg acgtttacaa gataattagt ttatcgtgta tgaagaagcg tttctttctc 2529421 ctcatccgtc cagctgacag ccttgccgct ttcctttgag acttgaacca tcacgactgc 2529481 cccggtgaag cagggttcgc cttcgaggtt ctctccgaga tagtgcaagg taagagatga 2529541 actgccgact gcgcttgttt tcacatagat gcgcaactct tcataaggca tgacttggcg 2529601 caaataatcg cattgctggc ttgccacgac tgtcatggtc tgtttgtttt cactcatcat 2529661 attcagcttt ttaaaataag aaatccgcac ctcctcaaaa tatataaaag gggttacatt 2529721 attcatatgc ccaaacatgt ctgtctcgga aaatcttacg gataccttat tgaaaaaaga 2529781 aaaggatgtt ttccattctt gaaacggcat atcaatataa gcgggaagct tcatcttttt 2529841 tcatctcctt attgtttaaa aaaacctctc ccatgcggaa gaggtttttt cttcttatac 2529901 tctgtcgctt ccgaagaaat tgcggaacgc ttgtaagttt gtatctctat tcaaggctgc 2529961 aatcgaagtg gtaagcggaa tccccttcgg acaggattga acacagtttt gcgagttgcc 2530021 gcaatctgca aggccgcctt catccattaa tgcttctaat cgttcagatt tattcatggc 2530081 gcctgtcgga tgcgcgttaa acaggcggac ttgcgacatc ggtgcaggcc ccatgaactt 2530141 cgatttgctg ttcacattcg ggcaagcttc gaggcagacg ccgcatgtca tgcattttga 2530201 taattcatat gcccattgac gacgtttttc cggcattctc ggccccggtc ctaaatcgta 2530261 cgtaccgtca atcggtatcc acgcttttac ttttttcaat gaatcaaaca ttctgctgcg 2530321 atcaacctgc aaatcacgaa cgactgggaa tgttttcatt ggttttaaac ggattggctg 2530381 ttcaagctgg tcaataagcg ccgtacaaga ctggcggggt tttccgttta taaccattga 2530441 acatgcgccg catacttcct caagacagtt catatcccat gtgacagggg ttgtcttctc 2530501 acctttgaca ttaaccggat tccggcggat ttccatcaga gcggaaatga cgttcagatt 2530561 cgggcggtat ggaatctcaa attcttcatc ataaggcgtg ctgtcagctg tatcttgacg 2530621 tgtgataata aatcgtatgg ttttttgttc actcatgatt atttcgccac cttcttcttc 2530681 gagtaatccc gtttccgagg cgttatcagt gatacatcga catcctgata ctcaaattcc 2530741 ggcgcttcat acgggcttac atgtttagcc attgttgttt tgagccattc atcatcatta 2530801 cgttcaggat aatccggttt ataatgggcg ccccggcttt cattacggtt gtatgcgcca 2530861 agggtaatca ccctcgcaag ctgaagcatg ttcgagaact ggcgtgtgaa catcgctccc 2530921 tggttgctcc attttgtcgt gtcattgatg ttgatctttt tgaagcgctc cattaactcc 2530981 tgaattttgt catccgtttt caaaagcttg tcattatggc ggacaaccgt tacgttcgcc 2531041 gtcatccact caccgagctc tttgtgaaga acataggcat tttcggttcc gtccatactc 2531101 ataatatcag cccatttttc ttcttctttc ttaacgtgag cgtcgaataa agatgaagac 2531161 atgtcttccg ctgaagattc taagccgttt acatatttca ccgcattcgg accggccacc 2531221 atgcctccgt aaatcgcaga cagcagggag ttcgctccca agcggttgcc gccgtgcata 2531281 gaataatcac attccccagc cgcaaacagt ccagggatat ttgtcatttg atcgtaatcc 2531341 acccataaac cgcccataga ataatggacc gccgggaaga ttttcattgg aagcttacgc 2531401 gggtcgtctc ccatgaattt ctcataaatc tcaatgatgc cgccaagctt aatatcaagc 2531461 tctttcggat ctttatgaga cagatcgaga tataccatgt tttcaccgtt aataccgagc 2531521 ttctggttca cacacacatc aaatatttcg cgtgtcgcaa tatcacgcgg caccaggttt 2531581 ccgtatgccg gatatttttc ctccaggaaa taccatggtt tgccgtcttt atatgtccac 2531641 acgcgcccgc cttcaccacg cgctgattca ctcatcagtc ttagtttgtc atcgcccggt 2531701 atggctgtcg ggtggatttg aatgaattct ccgtttgcat aatacgctcc ctgctgataa 2531761 acgattgacg cagcagatcc tgtattaatc atggagttcg ttgattttcc aaagatgatt 2531821 cccggtccgc ccgtcgccat aatgacagcg tctgaacgga aggattcaat ttgcatgttt 2531881 gtcaggtttt gtgcaacaat tccgcggcag gttctgtcat catctaaaac agcgccaagg 2531941 aattcccagc cttcgtattt tgtgaccaga cccgcaactt cgtatctgcg cacttgctcg 2532001 tccagtgcgt aaagcagctg ctgtcccgtc gtcgcaccag cataagcagt tctgtggtgc 2532061 tgtgtacccc cgaatcggcg gaaatcaagc aggccttcag gcgtccggtt aaacatgacg 2532121 cccatccggt ctaataagtg gatgatcgaa ggcgccgctt cacacatcgc cttgaccggc 2532181 ggctggttgg caagaaagtc tcccccgtat accgtgtcat caaaatgttc ccacggagag 2532241 tcaccttccc cttttgtatt gaccgctccg tttatgccgc cttgcgcaca aactgaatga 2532301 gaacgtttga caggaacgat ggaaaacaat ttaaccgcca ttcctgattc cgctgcttta 2532361 attgtcgcca tgaggccggc aagacccccg ccgactacga taatgcttga ttgactcatg 2532421 atagcccctc tccctctagt aatctagtac tcttaaacaa atgcaaaaat cgcttttaag 2532481 cctacgtatg acagtgcaac aaaaataatc agcgtaacgt atgtcgaaat tctttgagaa 2532541 cgaggcgtta ccgtgatgcc ccatgtaaca gcgaaagacc ataaaccgtt cgagaagtgg 2532601 aaaattgttg ataaaacacc gacaatgtaa aaaccaagca tagccggaga gctcaaaata 2532661 ttcgccatca tgtcgaaatt gacctcagca cccatttgtg cggcaatgcg ggtttcccac 2532721 acgtgccagc tgacgaaaat gagggtgatg ataccggtta cacgctgcag gacgaatagc 2532781 cagtttctca tgtagctgta ttgaccggcg ttatttttcg cagtaaacgc tatgtacaca 2532841 ccataaactg catgataaat taatggtaag aagataataa aaatttccaa ggcatacctg 2532901 aaaggcaggc tatccataaa atgagcagcg ctattgaatg cttcagcgcc ccttgcggca 2532961 aactggttga cgactaaatg ctgaataaga aagatgccga ccggtatgac gccaagcaag 2533021 gaatgcaatc ttcgaaaata aaactctctg ttcccagaca ttactttacc ccctgtttga 2533081 taagtgcgaa atgtgctaaa tctcttcccc cacttctttc aattgtaagc actttattaa 2533141 gatttattga caatttcatt ttactcctcc ctcaaaaggg cgtcaagaaa acgcgtacat 2533201 aaattataat tttccgaatt gattagttga ttgaaaaatt ttattttatc aatatatatt 2533261 tcttgcttaa tttttcataa gaattacagg atcattctgt aatcctcccc cctgtttgag 2533321 ctataatata cgcaggagag aggggagaca gatatgaagt ctaaatttga agcatctatt 2533381 gacaacctaa aagaaattga aatgaacgct tatgcctacg aactaatacg agagatcgtt 2533441 ctcccagata tgcttggcca agattactct tccatgatgt attgggcagg aaaacatctc 2533501 gcccgtaagt ttcctcttga atcatgggag gaatttccgg ccttctttga agaagcgggc 2533561 tggggaaccc tcaccaacgt aagcgctaaa aaacaggagc ttgaatttga acttgaaggg 2533621 ccgatcattt ccaaccggct taagcatcag aaagaacctt gctttcagct ggaggctggt 2533681 tttatcgctg aacaaattca attgatgaat gatcagattg ccgaatcata tgaacaagtg 2533741 aaaaagagag ccgataaagt ggttctgact gtgaaatggg atatgaaaga cccagtgtaa 2533801 tcaaaaaggc ggtgactgca tagtcccgcc tttttgattg tcattacaca gctgaagggt 2533861 gttttgaaag ctcaaatgca tcgtgaagcg actcgactgc tttcaccatg tcattttcgc 2533921 ttacgactgt tgacactttg atttcagatg tgctgaccat tttgattaaa atgttttttt 2533981 gcgccagtac agcaaacatt tcagccgcta caccgggatt tgagaccatg ccggatccaa 2534041 caatagatac tttagccaat ttgctttctg tctcgatttt ctcaaattcc agcgcgtctt 2534101 tatactcttc aagcaccgca acggtttggt ctgcatcttc tgttttgaca gagaaggaaa 2534161 ttccagtctt gtcctcggcc tgcgtttgga taatgatatc cacgtttatg tttcttttgg 2534221 caagtgttgt aaaaatagta gacaaagttg tcaggccgct agtcagcccg taaatggtta 2534281 ctcttgtgat ttgatcttca aatgcaatgc ctctgacaat taaattctgt tccatggatg 2534341 attcctcctc aattaatgtt cccgcttcgg tttctgtact tgaacgcact tctaacggca 2534401 cttggtaatt tttcgcgaac tcaactgctc tcggatgaag aacaccggcg cctaaattgg 2534461 caagctcaag catttcatcg tatgagatgc cctcaagttt tctcgctgat ttcacatagc 2534521 gcggatcggt tgtaaacacg cctggcacgt ctgtgtatat gtcacattta tcagctttta 2534581 aagcggcagc caaagcaact gctgttgtat ctgaaccgcc ccggcccaat gtcgtaattt 2534641 cacaatcctc tgtcatgcct tggaatcctg caacaatgac aatttttcct ttttcaagct 2534701 ggtctgctaa aaccgaagtg tcgatatctg taattctggc gtttccgtga atggcctccg 2534761 tacggattcc cgcctgccag ccagtataag acacagcgtc atagcctttt tcctgcaatg 2534821 ccattgaaag gagtgaaatc gtgacctgct cgcctgtcgc cagcagcata tccatttcgc 2534881 gtttgctcgg ctggtcagaa atagcttttg caaggctgac caattcgtca gtggattttc 2534941 ccattgctga aacgacgaca acgacttgat ggcctttctg tttttctgca attgcgcggt 2535001 ttgccgcatt ttgaattttt tcgactgagc cgacggaagt gcctccgaat ttttgtacaa 2535061 taagacccat gtattaccac cctttacatt ttggttcgtg cgggtgagga gaaagagcgc 2535121 tttgtccaca ataaaaaaag caatgagagg aatactctca ttgcttatca attaatcatc 2535181 ataaatgatt atgaacaacg agatagccct ccaagaaaat gatttcttga cagccttaca 2535241 tttattcaat gcacggccag caaataatac cgatggggtt ttatttgctt cggcgacgct 2535301 cccctttcag cctttttcac agaatccatc tttctccaaa ggcatactct tgaagttcgc 2535361 acctctatct tcaccatata acacgatcta actatgaaat tagttcacat tttatcagat 2535421 cttatttaaa aggacaacat tatttttgca atttgtcgta aaggagctga gccgccgctg 2535481 cgggaacacc ggcttttttg atgtcctcaa ggcttgcttc cttcattttt ttaacggaac 2535541 cgaaatgctt taacagcatt ttctttcttt tctctccgat acccgggatg tcgtccaaaa 2535601 cggattgaaa cgcgcttttt ccccggattt gcctgtgaaa actgattgca aaacggtgca 2535661 cctcgtcctg aatgcgctgc aggaggtaaa attcctggct gtttcgttcc agatacgcca 2535721 cctccagcgg atcaccgatc agtaaatttg aggttctgtg tttttcatct ttcgctaaac 2535781 cggcgatcgg gatatccaag ccgagttcat tttcaatgac atcccttgct gcgttgatct 2535841 gcccttttcc tccgtcaatg ataatcagat cgggcagcgg cagattctca cgaagcactc 2535901 tcgtatagcg tcttctgaca acctctctca tagaaccgta atcatccggc cctgtaacag 2535961 ttttgatttt atatttgcgg tattcctttt tgtatggttt gccatcgata aacacaatca 2536021 tcgcggaaac cgggtttgtc ccctgtatat ttgagttatc aaacgcttca attctgtgcg 2536081 gcgtataaat atttaatgcc tcacctagtt tctgcactgc cccgattgaa cgctcctcgt 2536141 cccgttcgat taaagagaat ttttctttca atgcgatttt cgcattttta tgggcaagca 2536201 tgagcagttc ttttttcggg ccttttttcg gctggtgaac gtttgtttcc agtagctgct 2536261 cgatcataga ttgatctatg ctgtccggaa ctaaaatctc cttcggaagg aagtggttgt 2536321 tttttgaata gaactgcccg atgaacgtga ggaactcttc atctgcttcc tgataaagcg 2536381 ggaacatgct gacatcgcgt tcaatgagct ttccttggcg gatgaaaaag acctgcacgc 2536441 acatccagcc cttatcgtac gcgtacgcga acacatcacg gtcgactaga tcgttcatcg 2536501 tcattttttg tttttccatc gttgattcaa tatgggcaat ttggtcacga agctcttttg 2536561 ctcgttcaaa ctcaagattc tcagcagctt catgcatttt ctcttcaagc tcttttttga 2536621 cctcattata gccgcccctt aagaaacgtg taatgctttc aaccagctct ctgttcgtct 2536681 cttcggaaat atcctttaca cacggagcaa ggcattggcc cagatgatag taaaggcaca 2536741 ctctgtccgg gagcttggag cattttctga gaggatacag acggtcgagc agtttttttg 2536801 tttcccttgc tgcctgtaca ttcggatacg gcccgaaata gcgccctttg tcttttttga 2536861 cattgcgggt gacaatcagc cttgggtggc gttcatgggt gagttttatg aaaggatagg 2536921 ttttgtcgtc tttgagcatg acgttgtatt tcggatcatg ctttttgatc agattcattt 2536981 ctaaaataag cgcttcaaga ttggaggacg tcacaatata ttcaaaatcc tcgatttccg 2537041 tcacaagcct ttgggttttc gcgtcgtgag aaccggtgaa gtaggagcgc actctgtttt 2537101 tcagcacttt tgctttccct acgtagatca cagtctgctg ccggtccttc atgagataac 2537161 aacccggttg atcaggaagg agggcgagtt tttctttcag ttgtttgttc atatgttacc 2537221 cttccttatg tttaatcctt tatttccagt ttaacacgaa cgtttgtttt tctctatggt 2537281 tcacaattgg cgaataaaaa aagcgatccc tcaatcggaa tcgctctggc atgtaagcag 2537341 cggaaaatta aagatgtttg tttacaagct cttgaagcgc ttcttttggt ttgaagccga 2537401 ctgaagtttc aactacttcg ccgtctttta acacaagaag agtcgggatg ctcataacgc 2537461 cgtattttcc ggcagtttct tggttttcgt ctacatcgat ttttacgatt ttcagtttgt 2537521 ctcccatttc ttgatccaat tcttcaagaa caggtgcaat cattttacaa ggtccgcacc 2537581 aaggagccca gaagtctgcc agtacgacgc cttcgcttgt ttcagctgag aaagattgat 2537641 cagttgcttt tacgatagcc attattgaat tcctccaatg tgaaatgatg atttttagta 2537701 tagcatctcc cattcgttca cgctatttta atgcttacaa attatttttt cctgatcaca 2537761 gccggtttac tcatttttat atggttgaat gggatatgct ctttttttaa aacacaaatc 2537821 tgataatggc cccgatcact acaattgccc caataatcat taaaatggta cgaagcataa 2537881 gatcacatct cctcttcact gtcatgtact ttaccatgcc ctgccggagc tgttttaaaa 2537941 cctgaaaaag agcgccggca tgaagctccg gcgctcttgc gcgattaaga atcagcacgc 2538001 agcgtaagta agacgactga cattggcggg agttttactt tcagtttgtt tttgctgagc 2538061 gtgtattgtc tgaaggattc cggtttgaca tgatgaggat cgtcaaacgt gttatgcgca 2538121 ttcatttttt ctgccgtaag aatgactccg gaatggtccg ctgccttgtg taggcccctc 2538181 agctcgattt ccgcctctgc tttgttttgg tgatcgatgt tgcaaattgt gatattgata 2538241 tcgccttcag cttgtttcga cgctgaaatg ctgatttgcg gaagcgtttc accgttccat 2538301 tcatagtcgg cagacattgt ctctgtggct aaaagagaag cgtcctggtg caccttaaac 2538361 atattgaata catggtacgt cggtgtcaaa agcatccgct ctccctcagt caaaatcatc 2538421 gcttgaagaa catttactgt ttgggcgatg ttggccattt gcacccggcg gcaatgctga 2538481 tggaaaatgt ggaaatgaga agccgccacc agtgcatcac gaatggtgtt ttgctgatat 2538541 aagaaaccgg gattcgtgcc tggctcggga tcaaaccacg tgccccattc atcaataatc 2538601 agcccgaccc gctgctccgg atcgtaccgg tccataatcg tgccgtgttt ttgaatcaat 2538661 tcatcgatgt atttggcttt tttcatcgta ataaaccatt catcttccgt gaattctgtg 2538721 gctgatcctt tgcccttcca gaaatccccc ggaatcgtgt aataatgaag actcaacccg 2538781 tccatcaggc cagcggcttt tttcataagc acgtccgtcc aattaaaatc atccacattt 2538841 gcgccgcctg caattttata aatgtcattc ccgctgtaat tgcggacata agtctgaaaa 2538901 cgccggtaca gatctgcgta gtattcggga tgcatgttgc cgccgcagcc ccagttttca 2538961 ttgcccacgc cgaaatattt cagcttccaa ggctcttctc ttccattttg ctttctccag 2539021 tctgacatcg gcgtgccttc ttcaaatgtc atatactcaa tccactccga catttcctga 2539081 acggttccgc ttccgacatt gccgcaaata tatggctcgc attcaagcag ctcgcaaagc 2539141 atcataaatt catgcgttcc gaattcattt gattcaattg taccgcccca gtgagtgttc 2539201 agcattgtct tacggtcacc gacaccgttt gcccaatggt attcgtccgc aaaacacccg 2539261 cccggccacc taaggacagg aatgtgcagc tgtttgagcg cctccagcac gtcctttcgt 2539321 atcccgttga tattggggat gtctgagtcc gttccgaccc agatcccctc ataaatccct 2539381 cttcctaaat gctcagcaaa atgaccgtat atatttttgt taatggttcc ttttgcgata 2539441 tctgtttgaa tcactgcttg atgttcagac atgcctctga tcattccttt catacggata 2539501 tgaaaagcac cacagtcaaa tatgtgatct gtcgtttgcc tgaggagtca gcatgaatgt 2539561 aagcgctttt aaagtaacca tattatatat gttcgtacat gtcaacgaca ttttctattg 2539621 tttttatatt tgtacgtatg tatttataaa tatgaaaaaa cccggacttt taaagtccgg 2539681 gatttccttt atgagtgtat attcagctgt ttgaattcct cagttaataa cgggacaact 2539741 tcaaataaat caccgacgat gccgtaatcc gctattttaa agatatcggc ttcggggtct 2539801 ttattgatgg cgacgatcac cttgctgttt gacatgccgg ccaaatgctg gatggcgccg 2539861 gaaatgccgc atgcaatgta caaatccgga gtaacgactt tcccggtctg cccgatttgg 2539921 agagcataat cgcaataatc agcgtcacat gccccgcgag aagccccgac tgcggcccct 2539981 agcacctctg caagctcctg cagcggctga aatccttcct tgcttttgac tcctcggccg 2540041 cccgcaacga taattttcgc ttcggagaga tcaacaccgt ccgccgtttt tttcacgacc 2540101 tcttggataa cagtgcggag gtcagtaaga gaaacatcaa tgctttcgat gctccccgat 2540161 ctgctggtgt ctttttctga agcttgaatg ttattggggc gaattgttgc aaagatcatc 2540221 ggatcggttg aaatgacgcg ttcaaaagct ttccccgagt aaatcggccg tgtgaacaca 2540281 acattccctc cggtaacgct tacatctata gcatcagaaa ttaagcctgt ttgcagacgg 2540341 gcagcaagct tcggtgaaag atccttgccc attgccgtat gcccgaagat gactgaatca 2540401 ggattttctt gctcgataac acctctcatg acctggctgt acccgtctgc cgtgtatgtt 2540461 ttcagcttcg ggtcctcagc ggtaagaact ttatctgctc cgtaatgaat aagctcttgt 2540521 gcaatgcttt gtacattttc accgatgaga acaccgatga cttccccatc tcctgaaatg 2540581 gttcttcctg cagctattgc ttcaaaggtg acatttcgca attccccatc gcgtatttct 2540641 ccaagcacga tcactttttt tcccattcta acatccccct gtttctttga atgtccaagt 2540701 tttaaatgac tttagcttcg ctgcggagca atgaaacaag ctcttttgcc tgttcagcag 2540761 gctcaccttg gagaagcttc ccggcttctt ttttcggcgg cagaaaacgt tcaatggttt 2540821 tcagctttgg ttcagcatcc tcttcgtcca gatcaagatc atcaagttca agctcttcaa 2540881 gcggcttttt cttagccttc ataattcccg gaagcgatgg atagcgcggc tcgtttaagc 2540941 cctgctgagc tgtgacaagc aatgggagcg tcgttttgat tttttcaaca tccccttcga 2541001 cgtccctttc tgcttctgca tcagtgccgt tgatttcgag tttggtgatc gtagtgatac 2541061 acggaatgtc cagtagctcg gcaagccgag gcgccacttg tcctgatcct ccgtcaatgg 2541121 caacatttcc gccgagaatc aaatcaaact cctgatcctt catatagtgg tataaaactt 2541181 gagaaatgga atattggtcg ggttcatcaa gatcatcttc tatgttgatt aaaacagctt 2541241 ggtcacaacc catggcaagc gccgtacgca attctttctc cgcttcttca ccgccgaccg 2541301 tgacagcggt gatcgtgccg ccatgctttt ccttcagctg gatggcttct tctatcgcgt 2541361 actcatcata tggattaatg atccattccg ctccgtcatc ctgaatcttt cctgtttcaa 2541421 tgacgatttt ttcttctgtg tcaaacgtcc gtttcatcag tacaaataga ttcatgatca 2541481 tatccccttt tattcgcctt tgaactgagg ctttcttttt tcgagaaatg cctggatgcc 2541541 ttccttggcg tcctctgact caaatgcttc cccaaatcgc tttgcttcaa gctttaagct 2541601 gccttcatag gaatacacct tgttggaata aagaagttca agcaaagatg ccagcgtttg 2541661 cgggcttttc tctgcaaact tagcggcaag tgcttttgct ttttcaatca cttctgcctc 2541721 atctttcgct ccaattgaga caagtccgag atcaagcgct tcttttccgg atatcggttc 2541781 tcctgatccg atgagctcca gtgctttggc tgtaccgaca tatctcggaa ggcgctgtgt 2541841 ccccgcaaaa cctggaatga taccgagatt aagctccggg agccccagct tagcatcttc 2541901 tgccgcgatt ctgatgtgac aggccattgc aagctccagc ccgcctccga gagcagcgcc 2541961 gtgaatcgct gcgataatcg gttttggaaa actttcgatt ctctccatta actgctggcc 2542021 gcgctcagcg agcaatgagg aatcctcatt gcctttaagc gatgtaaatt ctttaatatc 2542081 agcgccggct gagaaaaatc ttccctcgcc gtgaatgata atgcttcgta cgcctgcatc 2542141 tgtctcacat tgatcaagac aggaagacag ctcttctaat atccggcttg aaagcgcgtt 2542201 tgccggcgga ttgtgaatcg tcaagactgc cacaaattga tcaaccgcaa gtgaaattgc 2542261 attcatagga cagaactcct ttacttattg tgaattccgg ataccaataa ttctaaaacg 2542321 ctgtttgaaa gcgcaacgag atcgtacttt tggtcattca tcacccaagt tgtcacagtt 2542381 tcgtcaatcg ttccaaaaat catctgccgg gcgaggcgga catcgaggcc ttcttttatt 2542441 tcgcctgatt gtataccttc cgtcaaaatg ccatccaaaa tatttaagta gccttttaat 2542501 atttcgttga ttttttggcg cagctccaag ttggattggc ggagctcaag ctgcgtgaca 2542561 atggcgagat tatggtcacc cgctaaaagg gaaaaatgct ttgaaatcac aagcgccaat 2542621 ttctctttcg ctgttgcttt ttctttaatg tcctcttcca tccgctcaat aaattgaccc 2542681 attttttctt tgaaaagaga aattaaaata tcttctttgt ttttaaaata gagatagatg 2542741 gtgccgtccg ctaccccggc ttgtttggca attttggata cctgtgactg gtggtagccg 2542801 ttttctgcaa tgacttctac tgctgcatca ataatctgca tatactttgg ccgtttttgc 2542861 ttcaatgttc atcgttcctt cctatagaaa tgaatgacta ttcattcata atttcatgat 2542921 aagaaggatt ttcaggtttg tcaagtttat tcataggcgt tctctttttt tatttgatat 2542981 gatgattttc ggtttcttct tcaagtaaac gccttcttaa aatttttccc accgccgttt 2543041 tcggcagctc ctttctgaac tcataggctt tgggcacctt atagggagct agacgtgatc 2543101 tcgcaaaagc gtccagttct tctgtatcgg cttttgcgcc tttctttaat acgacaaatg 2543161 cttttactgt ttctcccctg taggaatcgg gaacgcctgc gacaacaatt tcctggatgg 2543221 cttcatgttc ataaagcgct tcttctacct cacgcgggta aatattgtaa ccgccggcaa 2543281 tgatgatatc cttcttcctg tcagcaatat agaaaaagcc ttcttcatcc atatagccca 2543341 tgtccccggt gaacagccag ccatctctca gcactgcggc ggtttcctct ggtttattcc 2543401 agtatccttt catgacttgc ggacctttta caatgatttc tccatgctca tacggagcgg 2543461 caagctcacc cgtctcttca gaatagatcg cagcgtccgt actcggccaa ggacagccga 2543521 tactgcccgg cttgtttttt ccccagataa agttggcgtg cgtcactggg gatgcctcag 2543581 acaaaccata gccttccaca agctttccac cagtcacctt ttcaaatttc tgctttacct 2543641 ccacggggag cgcggctgat ccgctaagac agcttttaat ggatgacaga tcataatgct 2543701 gcaattcagg gtgatgcaaa aggccaatgt aaattgtcgg tgcgccagga aagagcgtcg 2543761 gtttgtgttt gtcgatgatt ttaagtgttt cgagcggatc aaacttagga agaagaatca 2543821 tttcgaagcc tagtttaatc gaatagttca tgactgccgt cagtccgtag acatgaaaaa 2543881 atggaacgat gcccagcact ttttcagcgc cttctttcac gtcatacatc caagcggcgc 2543941 acatttcagt atttgccaaa atattttggt gcgtgagcat gacccctttt ggagctccgg 2544001 ttgttcctcc ggtatactgg aggacagcga tatcatgctc aggatcgatc ttcgggattg 2544061 tcaggagttc agttttttcc tgcttcatac aggaagcgaa cgtgtgaatg ttagctgttt 2544121 tgtcaaagtc gatatgcact ttttgttttt gcgtcagcgg gtaaagaata tttttcggaa 2544181 aaggcaaata gtcttttaca ctggttatca aaatctggtc gactattgat aacgttttca 2544241 tttttattgc cttcgggaaa agcaaatcta aggtgatgat tacacttacc tgagcatctc 2544301 taagctggta ttcaagctca tgctcggtat aaagcggatt cgtctgcacc acgatgccac 2544361 cggcaaacaa gacgccataa taagaaatca ctgtttgcgg gcaattgggc agcataacag 2544421 ccactctgtc tcctttttgc aggccattgc actgcaaaaa agctgcaagt ttaagagcat 2544481 ccgtcagaat gtcatgaaag gtgagttttt ttccataaaa cgatattgcg gttttatcag 2544541 ggaatcgtgc ggcggagtct gtcaggatgg attgcagggt tttattcggc aacggaagct 2544601 catgcgggat atcgttggga tactcggcaa gccacggctt ttgagactgc ataaaacctc 2544661 ccctttcgat tttagagatc caccttatca ttatagcaga tggacggcaa aaaaaagaaa 2544721 aagaaaggta aatctttctt tttctcataa tatgaacaga tatataagac caattaacaa 2544781 aaagattccc gctgcggcga gcagtatttt cgcaagcttt tccatctatt ctccgtcccc 2544841 ttatattccg gctgccacca caaaagaaag cccgacagaa atgacaaatg aaataaagcc 2544901 gacagcccgg ttatcatttt cgatttcctg atcaatttta aaccgcggag tcaaaaactc 2544961 aaaaataaag tagctgatca gaagcataac aaacccgtaa acgccccagc cgatcatttg 2545021 cagcagcgaa ttatgctggg agatggaatg ctgaaatacg tttgcgattc ccaaaatttt 2545081 tccgccggtc gccattgcca ccgcaagatt tcctttttga atctcttccc agtttttata 2545141 agccgtcacc agctcaaaca cagtcaaaaa gaggacgagg cagagaaccg cgacactgta 2545201 atatgccgcg atttccacaa gctcgttttc ccaaaaatca ctcatggcca tactcccttt 2545261 tattttagtt caacaaccgt aacgcctgat cctccctcac ctgcttcacc gaaacgggaa 2545321 cttttgacgc tgcggtggtt tttcagaaga tcctgtacgc cttttcttaa agcgccggtt 2545381 ccttttccgt ggatgattga cactcttgga tatccggcta acaccgcatc atccaagtat 2545441 ttttcaaccc ggctgagggc attttcatag cgttcgccgc gaagatcaag ttcaagcgat 2545501 acgtgatagt cctttccttt gaccgctgta atcatttttt ctttttttgg ctccggagct 2545561 gatttgataa actccagatc tttttctttt actttcatct ttaaaatacc gatttgaacg 2545621 ttccattcat tgccgcctgt tttttcgagc aatgttcctt tttgcccgaa agtgaggact 2545681 ttcacctcgt cgccaggctt aaagtcgcgt ttttgcgttt tcggcttttc cggtttcttg 2545741 gacttttcaa aagcaggcat agcgccttct aaccgtttct tcgcgttaat cagctcgtga 2545801 tccttgaagg atttgtgttc ttcttttatg gtgcgcaatt catgaataat gtcctcggct 2545861 tctttcattg ccgcttttac tttttcagca gcctgctgtt ctgcctcttc aagcattttg 2545921 tcttttttgc tgttaagctc gatgatttgc tgctgcagct ctttatgcag tttttccgct 2545981 tcttttctga ttgattctgt ctcagaaagc tcttcttccg cacgtttttt gctttgttcc 2546041 agcgacgcaa tcatcgtatc gacttcgtta tgctcggccg tcatttctga cttcgcctgc 2546101 ccgatgatat ggtccgggag cccgaggcgt tttgaaattt cgaaagcatt gcttcgaccc 2546161 ggcacaccaa ttaaaagttt ataggtcggt gacagcgttt cgatgtcaaa ttcaacgctg 2546221 gcattcatga cgccttctct gttatagccg tacgccttca attccggata atgcgtcgta 2546281 gctaacactc gtgcattggt gcgatgcacg tcatccaaga tgctcatggc gagggccgcc 2546341 ccctcctgcg gatctgtccc tgcaccaagt tcatcgaaaa gcacaaggct gttttcattg 2546401 acctgttcta aaatgccgac aatattcacc atatgggatg agaacgtact taaactttgc 2546461 tcaatcgact gttcatcacc gatatcagcg aatacgtgct caaatactgc cgcttctgac 2546521 ccttcatctg ccgggatatg aagacctgac tgcgccatta aggttagcag gcctaacgtt 2546581 ttaagggtga ctgttttccc cccggtgttt ggccctgtga tgacaatggt tgaaaaatcg 2546641 cggccaagct cgatgtcatt ggcaacaacc tgatcaggcg gaagcaatgg atggcgggct 2546701 tttttcaaac ggataaagcc ggtgtcgttc ataatcggtt ttgtcgcttt aaccgctttt 2546761 gcatatctag cttttgcaaa aataaagtca agcgtctgca gcacttgcaa atctagaaat 2546821 agctcctctg tatactctgc cgttttctct gtcagcacac gcaaaatccg ttcaatttct 2546881 tgcttttctt tcactttcgc ctgctgaagg gaattgttca tatctacaat cgcctgcggt 2546941 tcaatgaata gtgtcgcacc agaggatgag gtgtcgtgca caattcctcc atagctggat 2547001 ctgtactcct gtttgaccgg gatcacaaag cggtcattcc gaatcgtaac aatcgtatca 2547061 gacagcattt tcgatgcgga agaggaacgc agcatcgact ctaaccggtc tctgactctt 2547121 gattcgagtg ttctgagctg tgtgcggatt cctcttaatg tttccgatgc atgatcaagc 2547181 acttctccgt gatcatcaat gcaggaatta atgtcccgct ctaaatcgga cagcgtgata 2547241 agctgttcag catgctgatg gatcagcgga atgtcgacac cgtcttcagc catttgcgtg 2547301 ataaaatgtt tcatttgttt aactgcataa agcaggcctg agatttcagt gaattcagaa 2547361 ggactgagaa cgctgccgat ttccgcccgt cttaacgctc ctctgatatc tacaaggccg 2547421 ccaaatggcg cttggcctct cagccggata atgtcagaag cttcgtctac ttcatccagc 2547481 tgttttttga tttcgtctat agaagcagaa ggcttaagct cgagaagcat ttcttttccg 2547541 agcgatgaag cggcatgccc aataacctgt tctttcactt tatgaaattc aagagctgat 2547601 aatacttttt gctgcacgat tgtgtgagcc tccttactta atcgttgcgc ttcagaaatg 2547661 cctctacgtc tttaagcgac cgggcattca gaacgttttt cgtttccgtc catcctttgc 2547721 gcgcggcagt aacgccagtt ttcatatcgt ctaacatctc aatattatgg gcatcagtat 2547781 taatcaccaa tgtaacccct tgttcgtttg ctttcattaa atgctctgtg cgcagatcaa 2547841 ggcgcgcagg gttggcattg agttcaagcg ccgtatttgt tttcctcgca agctcaatca 2547901 gctgatcaat atcgatttcg taaccggccc gtctgccgat aaggcgcccg gtcgggtgtg 2547961 cgataatgtc aacatgcttg tttgtcagtg ccgtctcaag ccgtttcata atcacgtgtt 2548021 ccggctgatt aaaactggaa tgaatcgatg caataacgat atccatttcc gcaagcacat 2548081 cgtcatcata atcgagcgta ccgtcaggca ggatatccat ctcaacgcct ttcaaaatac 2548141 ggaagttttc aaactctgca ttcagcgcgt caatttcttt tgcctgctgc ttaagtcttt 2548201 ctgcagtaag cccgttggcg acctttaaat attgtgagtg atcggtgatc gccatgtatt 2548261 gatagccttt tttgatgcag gcttcagcca tctctctgat cgaaaatgcg ccatcgctcc 2548321 acgttgagtg catgtggaga tcacctttga tttgcccgag ctctatcagt tcaatgctgt 2548381 cgctgtaggt ttccacttcc tgtccgcttt cacgaatttc cggcggaatc agcggcaggc 2548441 cgaagtgcgc ataaaattca cgttcactcg gaaatgtttt gatctctccg gtttcaactg 2548501 tctcaacgcc gtattcactg atccgctcgc cgcgttcttt ggcgatttgg cgcatcttaa 2548561 tattgtgatc ctttgatccc gtaaaatgat ggagtgttgt cggaaactgc tcttccgtca 2548621 caagacggaa atcgacgctt gtttcatatt caaaggaaag gatgacggac accttcgtat 2548681 ctccgcttgc gatcacgctt ttgatgtttg gcagctcaag aagctgctct cttacttcag 2548741 ccggatgatc tgtagcaatg atataatcca gatccttcac cgtttcccgc gctctgcgga 2548801 gacttccggc acgagaaaat ttgatgatat gcgtaaattg agaaagatgc tcctcaattt 2548861 cccgcgcgat ccggagggcg tagccgatcg ggaaccgttc aggctgtttt ccggcttccc 2548921 cgagcgcctg taatattttt tcttccgatt ttttgccgaa gcccgcaaga ccctggacct 2548981 tttgctgctc acaggcttcc ttcagagatt ctgcatcgtg tacgccgagc tctttataca 2549041 gctttgcgat ttttttgccg ccgagccccg gcagcttcaa taaaggcacg agtccttccg 2549101 gcacttcttt ctgaagcgat tcgagcgtgc ttgactttcc ttcatctata tactctttaa 2549161 tgacgctgta cgttcctttt ccaatgccgg acagcgacat catatcgtcc atttctgata 2549221 agcttcggtc gtcctgttcc agagctgccg ccgcttttcg gaaggcggat actttaaacg 2549281 ggttgtcccc tttgagttcc atatagactg caatggtttc aagcagccgg ataatatctt 2549341 ttttatgcat atcataaccc ccagacgttc acatatgttt ccatcatact tgaaaaaaac 2549401 ttctccggac aagagaagtt tttttatgcc ccgtactgtg tccacagctc ttgtaaaagc 2549461 cctgacaagt acggtgtatg gttaatgatc acatttgcga gagacgattg ccccatcatt 2549521 tgctgcaacg cgtctaccgg cagaacggat gcgacataca gcagcacaaa tgtaaataaa 2549581 tagacttcta gaaaaccgag aacggctccc agcatctggt tgatttgttt aatcaccgga 2549641 atgccggcta caatactcag gaacgagccg atgattctca gtaagatttt agcaatgata 2549701 aataaaacga taaacgcaat cgcattatag tacgctgctt ccaaattccc cgtaaaaaaa 2549761 gaaagagccg gctgtcccgc tgaaaaatcg ggtgcgggaa tccaatgtaa atgcggtgcc 2549821 acgtttttat agaataaagc cgcaaaggca attgataaaa taaagctcgt caagcggata 2549881 aactgcagga taaaaccgcg ttttaacccc agtaaagtcc ccatcaggag caagattaag 2549941 atgatgatat ctagcatagt tgttcaatcc ttttctttaa gctgacgctc cagtttttca 2550001 catttctctt gtaatttgac ataatcgtgc accacattta ccgctgtcag cactgcaagt 2550061 ttatttatat caaggtatgg atttttttca ttgatttctc tcattttatc atcaacaatt 2550121 ccggcgacat acctcatatg ggctctgctt tcttcaccga caatcgtgaa gtgctggccg 2550181 taaatgtcaa cggttgtttt tgtttttttg ccgtcagaca acgtttctcc tccattccgc 2550241 gagaatccta gttcttatca taacacgttt attaaatgaa tggaaagacg agcctcccgc 2550301 tgttatgata cactggtata tacagcgaaa agtgtaaaaa aaggagatta ttacgtgtcc 2550361 cattcagtga taaaagtatc gttgtctgct attgaccaaa tgaaaatgac gtacagcggt 2550421 tcacttacag cctctgttcc gcagggagcc gtttttcagg caaaaccgcc cggctgtacc 2550481 attacagcat atcaatcagg taaggtcttg tttcaaggaa aaaacgctgc ggcagaatcc 2550541 gcgcgctggg gaacagcaga gcctcaggaa aagaagaaaa cggccaaaaa gccggctgat 2550601 ccccgctatg cccctccggc agatatcgcc ggaatgtctg ttatcggttc tgacgaagtc 2550661 ggaaccggag attactttgg cccaatgacg gttgtatgcg cgtacgtcga caaaaccatg 2550721 cttcctttaa tgaaggaact cggtgttaag gattctaaag atttaaaaga tccgcaaatc 2550781 atcgagattg cccgaaacct gattaaaacc attccgtaca gcctgctggt gttaaagaat 2550841 gaaaagtata acagcatgca ggaaaaaggc atgagccaag ggaaaatgaa agctttgctg 2550901 cacaatcagg cgatcacaca tttattaaga aaattggatg gagtaaagcc tgaagccatt 2550961 ttgattgacc aattcgctga gccaggcgtc tacttcaatc atttaaaggg cagagacatt 2551021 gtgaaggagc ggacctattt tagcacaaaa gctgaaggta ttcacctggc tgtcgccgct 2551081 gcttcaatca ttgcaagata ttcattttta atggaaatgg ataaactatc acgcgcggca 2551141 ggaatgacgc ttccaaaagg ggccggtccg cacgtcgatg aagcggccgc caagctgatc 2551201 ctcaaaaaag gggcatctgc actcagaacc tttacaaaac tccatttcgc caatacgcaa 2551261 aaagcgcagc gccttgctga taaaaaacgt tcatagaaaa aagcttgcag atttctctgc 2551321 aagctttttt atcagcctct taaaacagct tgatatgtgt cttctaacgc tttcagcact 2551381 ttgctgtgcg cctttgtcac ttcttcttca gtcagtgttt gttcaggatt gacatactgg 2551441 agtgagaaag cgactgactt cttgccttcc tccatatgct ctccttcgta tacgtcaaat 2551501 acggttacct ctttcagaag cttgcccccg gcctctttaa tgacgctctc gagctgtccg 2551561 cttgtgacgg ttttatctgt tacaagagcg atatcacgtg tcacagacgg atattttgga 2551621 atcgccgtgt aaacaagcgg tgctgtttct gctgcgagca acgcatgaag atcgagctca 2551681 aatacgtatg tttcctttat atccagttct ttttccaatg aaggatggac ttggccgatg 2551741 aagccgatca gagaaccatt caataaaatg ttcgctgttc tgcccggatg cagctgtttg 2551801 cgttcagact gtacaaattc aatgctgtct aggacgttga gtttgtctaa cagcccttcc 2551861 acaattcctt tgacaacaaa gaaatcaact ggtttctttt caccctgcca tagctgcttg 2551921 cgccataatc cggtaacagc tcctgctacg cgttctgttt caacaggttt tgtgtcctct 2551981 tccttcgtta ggaaaacgga gccaacttcg tacagtgcaa ctgagtcagt ctgcctcgca 2552041 agattgtaag aaacagaatc aagcagattt ggaacaagac tgtgtctgag aatgcttctt 2552101 tcttcactca ttggaagcgc aagcacagta ttcagtgatt tttcaatcgc aaacgctgtc 2552161 gctttcttct cgtttgtcag tgagtaagtg atggcttgtg ataagcctgc gccttcaagg 2552221 aagcgtctga ctttacggcg ttttgcctga tatggcgtta atccgcctgt agttcccgct 2552281 gtctcaggaa gcgtagacgg aatgttatcg tagccgtaca gtcttgccgc ttcttcgatt 2552341 aaatcctctt ctattgtaat gtcaccgcgc cgtgatggga cagtcacaac gagaagatca 2552401 tccgcttcac cgaccgtaaa accgagacgt ttataaatgc tgatcagttc ttctttactg 2552461 atcgtcaggc ctagaacgct gctcactttg tcagcagata cgtgaatgtt atttgcttcg 2552521 attgtcaggt gatcttcctc aaccgttcca gcaagcacct caccgccggc atacagatgg 2552581 atcagctgcg cagcccgttc tgctgcaaga cgtacgcgtg ccggatcaat tcctttttca 2552641 aatcttacgc ttgattcact tctcaaacca aggtctttgg aagccttgcg aaccttctgc 2552701 ccgttgaaat acgcagcctc aagcaaaatg gttttcgtat cttcctgaac ctctgactct 2552761 gctcctccca tgacaccggc aacggcctgc gctttcgttc cgtttgtaat gacaaggtga 2552821 tcggcagaca gcttacgttc ttgatcatca agtgttacga tcatttcatt ctcagctgct 2552881 tttcttacta cgacttcctt agagccaaat ctgtcataat caaacgcatg aagcggctgt 2552941 ccgtattcca acaggacaaa atttgtgatg tcaacgacgt tgttgtgcgg acgaatgcct 2553001 gcattcatca gctttgtctg catccaaagc ggtgacggag caatcgtgac atttttaatg 2553061 atttttgcag tgtacagcgg gttcgcttct tgatcttcaa ttttgactga aatgtaatca 2553121 gacgcttgtt ctgaagcagc cgggtaatcc gtttgcggaa gctttacctc agtgtctaaa 2553181 atcgccgcaa cctcgtaagc aacaccaagc atgttcatgg catccgcgcg gtttggcgtt 2553241 aaacccagct caagaatcgc atcgtcaagc tgtaaagccg ctaaggcatc gcttcctgtt 2553301 tcagcgtcat tcgggaatac gaaaatgcct tctgcatact ccttcgccac aagtttgctt 2553361 tcgataccaa gctcctgtaa ggaacagatc atgccgtttg attcttcacc gcgaagcttg 2553421 gcttttttga ttttgaaatt gcccggcagc accgctccga ctgttgcaac tgcgactttt 2553481 tgtcccttat ccacattcgg cgcgccgcaa atgatttgta caggggcttc agctccgata 2553541 tccacaaggc acttattcag cttatcagca ttcgggtgct gctcgcgctc cagcacatgg 2553601 ccgatgacaa cgcctttgat gccttctcct ttgtattcaa ttccttcaac ctcaataccg 2553661 gctcttgtaa ttttttcagc aagaacagcc gggtccatgc cttttaaatc aacataatcc 2553721 tctaaccatt tataagaaac aaacatcctt gcatcctcct cttacgcctg tttaaactgc 2553781 gaaataaatc tgacatcgtt tgtatagaag tggcggatat catcaatgcc atatttcagc 2553841 atcgcgatgc gctcaacacc cattccgaat gcgaagccct gatattcctt cggatcaaag 2553901 ccagccattt taagcacgtt cgggtgaacc attccggcac cgaggatttc aatccagcct 2553961 gttcctttac atactgagca gccgttccca ccgcatttaa agcatgtcac atccacttct 2554021 actgaaggct cagtaaacgg gaagaagctt gggcggagtc tgatttcacg gtcttgcccg 2554081 aacatttttt tcgcaacaag ttcaagcgtt ccttttaaat cactcatgct gatgtttttg 2554141 tcaacgacaa gcccttcaat ttgcataaat tggtgagagt gcgtcgcatc atcgttatca 2554201 cggcgatata ctttacccgg gcaaatgatt ttaacgggac ctttgccttc atgcttttcc 2554261 atcgtacgtg tttggacagg agaagtttgc gttctcatca aagtttcctc tgtgatgtaa 2554321 aagctgtcct gcatatcgcg cgctgggtgt tctttcggaa gattgagcga ttcgaagttg 2554381 tagtaatccg tttcaacctc tggcccttcc tcgactgtgt agcccatacc gataaataaa 2554441 tcttcaattt cttcaatgac aacagtgagc ggatggcggc cgccgactgc aacagggttc 2554501 cccggcagcg tgacgtcaat tgtctgtcct gcaagcttct gtttcatttc ctcttcttca 2554561 agcttctcgt ttttgtcagc aatcgcattg gcaatacgct cccttacttc gttcgcgagc 2554621 gcccccattt ttggacgttc ctcagcagaa agcttgccca ttccgcgcag cacttctgta 2554681 atcggccctt tttttccgag atattgcacc cgaatatcat tgacaacctt caatgagctt 2554741 gccgcttcta cttgttctaa agcttcttgt tccagctgtt ttagcttttc ttccattttg 2554801 catcctcctt ttatgtaaac aaaccgtcat atgtctttgg aaaataaaaa aaacccgtcc 2554861 cttgtacaag ggacgagttg tggccgcggt accaccctta tttcagacag actgatgctg 2554921 tcgtcagctt cattgacata acggaatcag attccggttc acctttacgc gcagtgtacg 2554981 cggtcccggc gacaactcaa gaggtgaagc caatttccgg ctgcgttaaa aatgctctca 2555041 gtcagcggca ttttctccct ggaaagcagt tgatcagaaa ttgaggtcct ctgtcacggt 2555101 ttttgaaata ttatgttcta ttatagagaa atccaacgct tggcgcaaca ctatcctcgc 2555161 aagtgataca cgaggatggc agccgcaacc gcaacgttta gtgattcagc ctgtccgtaa 2555221 agcggcacgt acaggttcaa atccgttttt tccagcaatg cagcatctac ccctgcacct 2555281 tcatttccta caatgagcgc aaaggattca gactgaggaa tctcctggta aggcgctccg 2555341 ttttgcagcg ccgtgccgta tacttttacg ccctctgcct tcaattcgtc cacatatgaa 2555401 ggcaggtttc ttctcacaac aggaatatgg aagtgagatc cttgagcaga tcgcagtgtt 2555461 tttccgttaa aggcgtccgc cgtgccgtca ccgagtacaa ccgcatccaa accggccgca 2555521 tcagccgttc gaatcattgt gccaaggttt cccggatctt gaacagcgtc aatcagcagc 2555581 accttgcgtg ccgttgccag cttttcttca ggcatatggc acacagcggc aatctgctgc 2555641 ggcgtttcgg tttcagtcac agctgaaaac gcatcttcac tcagcatata gcactggata 2555701 ccagtctcaa gatctgaagg aatcctcgtt tcatccttta caaggatttc tttcacaatg 2555761 cccgggcttt tcaacgcctc ttcaacgagg tgttctccct ctatcagaaa tgtatttgtt 2555821 tttgttcgtt ctttttttgt gtgaagcttt ttccaatcct tcactttttg gttttttgcc 2555881 gattctattt gtttcactgt ctatgtggcg ctcctttttt taacatgatg ttattatatc 2555941 gcaagaacag cacataataa accaggtgca gggttagaat atacgtatta cattttagaa 2556001 aaaggagcgt tttacatgga tcttaattta cgtcatgccg tcattgccaa tgtcaccggc 2556061 aataatcagg agcagcttga gcatacaatc gtagatgcga ttcaaagcgg tgaagaaaaa 2556121 atgcttccag ggctcggcgt tttattcgaa gtcatttggc agcacgcatc cgaaagtgag 2556181 aaaaacgaaa tgctgaaaac gcttgaaggc ggattaaaac ccgccgaata agacatgaaa 2556241 ccgggtgaca gcgcccggtt tttttcttat ataataaaaa catgatgagg gggaacgcca 2556301 tgtttttaca gccgttatta gcgaaaaaaa ttattgctga agttaaaaaa atgtacgaac 2556361 gtgaagtcat tattgtaaac acggacggtc ttattatggc aggcacaaac gatgagcgtg 2556421 tcggacaatt tcatgaggga gcgcttatct gcgcaaaaga aagacgcagc gtgattatta 2556481 caaaagaaga tgaaacaagg ttaaaaggag tgaaagcagg cataaacctc cctgtatttt 2556541 ttgaccatga tgtgattgcc gtcttcgggc tgacaggtga gcctgcagag attcagccat 2556601 tcggagaact gcttcgaaaa atgacagaac tgttcattaa ggaatcgcgg cacttagagc 2556661 aatcccagtg gcgtgagaga atgctggagt cctttatgat cgattggctg caattaaagg 2556721 agtggtctcc cagttttctt gagaaagctc agcttcttgg tgttgacctt tcttcccggc 2556781 gccaaatgat tcttattcag gggtatgagt ggtcacctca tgatattgaa caaatggcac 2556841 gcagctggaa atcctcgtac cctgcggatt tgttcatcag gtggggaaat gaacggattt 2556901 tgattaatca tgaagtgccg cagcatgaac aaagggatcg gcttttgcgg aaaatccttc 2556961 acatttgttc gtttgccaat accgcaagca gccaatatac agcagctggc gccggaaggg 2557021 ctgtcgcaag ctccagcctg acagattcat acgagcaagc ggaaaaagcg ctggctgtca 2557081 gccttaagcg aaaaacgccc atatttgaag aggatctgaa gcttgatatg tgtctgacgg 2557141 agatcagccc gggaacccga aacgaatttc cgcaaagagt attaggaaag gcgctagagc 2557201 atcaggaact tatgaatacg atacggactt tctttcatca cgatttgtct ttgaaacaaa 2557261 ccgctgaaga catgcatata cacatcaata cattgcgtta tcgtctggct aaggctgaac 2557321 agctgacggg attacgtttt gaccgtaccg aggacgtcgt cacgatgtac gtcgcactct 2557381 attttttaga tcaagataca aaatagagag agtttcagtt tcattttttg tatgtttctc 2557441 catggaaggc tttgcttttt ttcttttaca atagattgaa agcgtttttt gacaggggga 2557501 tgggtgaaat gatcaccaag gatgtaaagg agcagctgat tcaggtctcc ggaccagaaa 2557561 actttgatga ctcgaatgcc ggccgtctcg tctattcata tgatgcgacg cctcagtatc 2557621 agtctatgcc tgatgccgtg attgctccga ggaatactga tgaaatatca cgcattttaa 2557681 caatttgcag cgaacatcga gtgccgatcg ttccaagagg atcagggaca aacctgtgcg 2557741 gcggcacgtg cccgactgaa ggcggacttg tgcttctctt taagcacatg aaccagattc 2557801 ttgaaattga tgaagaaaat ttaactgcca cagttcagcc gggcgtcatt acgttggata 2557861 tgatccgggc agttgaaagc aaaggtttat tttatccgcc tgacccgagt tctatgaaaa 2557921 tatcaactat cgggggcaac atcaatgaaa attccggcgg gctacgcgga ttaaaatacg 2557981 gtgtcacccg cgactatgtt attggactgg aggttgttct cgcaaatggt gacatcatcc 2558041 gcaccggcgg aaaactcgca aaggatgtgg ccggatacga tctcacacgt ctttttgtcg 2558101 gctcagaagg aacactcggc attgtgacag aggcaatcgt caaactcgtt ccaaagccgg 2558161 aaacaaagaa gacgctgctt gccctttatg aaaacatcga tgccgctgct caaacggtat 2558221 cggacattat tgccgcaaaa attatacccg ctacgcttga atttctcgat cagcctacac 2558281 tattggtgat tgaggattat gccaaaatcg gacttccgac aagcgcaaaa gcagttctgt 2558341 taattgaaca agacgggcca tttgaaactg ttgaacggga tatggaaaag attgaggcga 2558401 tctgcaaaaa aggcgacgcc gtatccgttc agaccgcaca aacagaggag gaagcgtttg 2558461 ccctgactga agcccggcgt tctgcacttt ctgccctagc ccgcctcaaa ccgacgacga 2558521 ttttagagga tgcgaccgtt cctcgctcag aaatcgccaa tatggttaaa gcgattaatg 2558581 atattgctgc taaatatgat atttccatct gcacctttgg tcatgcggga gacgggaacc 2558641 ttcacccgac atgcacgaca gacataagaa ataaggatga aatggaacgt gtcgaacagg 2558701 cttttgccga gatttttgag aaagcgattg aacttggcgg gacgataacc ggagagcacg 2558761 gagtcgggga aatgaaagcg ccttacttgg aaatgaagct gaaaaaagaa ggcattgatg 2558821 cgatgaaagc gttgaaagcg gcatttgacc cccggaacat attaaatccc ggcaaaatgt 2558881 ttgcgaaaga tgccagaaaa cgtgtggtgg cggaaagatg acaacagaaa aagaaatgaa 2558941 acagatccaa aatgaattta aagagcgtat ggatgaagga gagttattaa attgtatgcg 2559001 ctgcggcttc tgtcttcctt cctgtccgac ctatatcgaa tcgggatttc aggaaacaca 2559061 ctctccgcgt gggcgcatcg ccttaatgaa agccgtagcc gacggtatga ttgaaccgga 2559121 tgaagatgtc gaacggtcgc tgtcactttg cctcggctgc cgcgcctgtg agcctgtatg 2559181 cccgtctggc gtgaaatacg ggcagctgct tgaggaagcc agagatatta tccaccaaaa 2559241 taaaaaacac tctcttggtg aacgtgtcat gcgaaagacg gcttttcacg agctgtttcc 2559301 gcatcaaaac cgcatgcgct cagctgtaag ccttatcggt ttgtatcagc gttcaggact 2559361 gcaaaccgct gtgcgaaaat caggcatgct tcgggtcctg cctgagcatt tgcggacgat 2559421 ggaagctgtt cttcctgatg ttccaaaaag caaagacatg aaacatcggc cgcgtttcct 2559481 gccttccatt ggccccatga aaaaacgggt cgcctttttt tcgggctgct taatggatac 2559541 aatgttttta ccgaccaata acgccacatt gaagctttta cagctggcag gctgcgacat 2559601 tgtcattccg cctgaacagg cttgctgcgg ggcgcttcat ggacacagcg gtgaaaaaaa 2559661 cacagggaaa gagctcgcga aacaaaatat cgctgctttc gaagcattag acgtggatgc 2559721 agtcattaca aacgcaggag gatgcggagc ctttctcact gaatatgatc atttgctgaa 2559781 ggatgaccct gagtggtcgg aacgggctgc cgcttttgtt caaaagctga aggatttttc 2559841 ttctgttttg gttgaactcg atttccatca aatggatcta gcactcgaga cgcctcaggt 2559901 cgttacctac caagattcat gtcatctaag aaatgtgatg catacgtcac ttgagccccg 2559961 ccagcttctt aaaagcatca aaggggcgga attcaaagaa atggagaaag cagacagctg 2560021 ctgcgggtca gcgggaattt acaacatcgt cgaagttgaa atgtctatga aaatactgga 2560081 cagcaaaatg gctgccgtca aagcaaccga agcgatcctc attgtaacag caaatcctgg 2560141 ctgcctgctg cagatgaagc tcggcattga acgcgaagga ctaagcggta aagtcagagc 2560201 cgttcacctg gctgatttgc tattagaagc agccgggcac aaaacatcat gagaaagccc 2560261 aaaacagaca ttgttttggg cttttgtgcg ttattccatc ggactgcaaa tttcgatata 2560321 atgtccatcc ggatcagcga tataggcgac cgtctgcccc catggtttca ctttcggctc 2560381 cccgataatc gatacgcctt gttctctcat ccttttgatg accgcttcta cattttcagt 2560441 aacaaacccg atttcaaatg tgtttgaagc agatgtatcc ggaatgtcca gcgccgtgat 2560501 gtctctggcg ctttcccggg tattaagcgc caatatcgta gaccctgtat caaattcgac 2560561 atacgtgccg tgttcagcac gaatcggcag tcctaaaata tcccggtaaa aaatgaatag 2560621 cccgcttgct gtccgatacg tatagaataa gatatttcat tgatagattc attgccaacc 2560681 cctctcagca ttttcaatag tccttctagc ccggtataga tgcttccatc cttaagctcg 2560741 gatctttcca catctgcgcc cattttttca cagccgccac gataatgatg aagcctaaca 2560801 ccagcatgat gatagataat acgccattca atacactata tcctgctgct tcaggattga 2560861 gatacacatt gcgcaccatc caatagcccg cataattgac agtgacatat aaataggcaa 2560921 gcgggataag gcaagtcaga atgtaccggc gtttatcggc gattttcagc acgatcgtcg 2560981 ctccgataat cagccccact gaagccatca gctgattaga aacgccgaag agcgcccaaa 2561041 tggaaccgat atctcctgaa tacagcaagt acccccacat caaacaggca agcgcgctgg 2561101 caaatacaga gcccggaatc cagtctgttt tcttcagcgg cttatacacc tccccgaaga 2561161 agtcctggat caaataacgg gcgacacgtg tgccggcgtc aatcgctgtt aaaataaaga 2561221 ccgcttcaaa cataatgaca aattggaaaa agtatgaggc caaatggctg aaaaacggca 2561281 ttccggtaaa aatataagtc atccctaccg caagcgtgac ggctccccct gttcttcctt 2561341 ctaagtccaa accgatttcc ccgctcaatt caggcaaatg tacgacattc atgccaagcg 2561401 tacggaaaac ctcaggcgtg ctgttaatcg caaagtaatc agcaggctgt aaagcggtcg 2561461 ctgcaatcag cgccatgata ccgacaagac actcaacaag cattgcgcca aacgcaaccg 2561521 gcttcatatc actccattta ttcagcattt tcggtgtcgt tcctgagccg acaaaggcat 2561581 ggaacccaga gatcgccccg caggcgatgg ttattgagat gaacggccag acaggtcctg 2561641 ccagcaccgg ccctccgcct tttacgaatt ctgtaaacgc agggaacgga atggacggat 2561701 tgacgacaaa cacaccaaca atcaaagcga taaaaacacc gattttcata aagctgctta 2561761 aataatcacg cggagccaga agcagccaaa cgggaagcgc agccgcaaaa aacgcataaa 2561821 caggaagcgc gattgcaagc gttttcgtat ctagcgttaa aaagtcaccg agcgcggtag 2561881 tctgtaccca tggaccgata aagactcctg ccattaaaaa gagaaagccg accgttgaag 2561941 cgagctttaa atttcccgtt ttcttataaa ataagcccac acccatcgca atcggaatcg 2562001 taatccccac cgcaaatgtt ccccatggat tacgttcaag cgcatgcaag acaaccatcg 2562061 acaggcccgc cattgtgatc gtgatgataa acagcatgga cagtcctgta caaaatcctg 2562121 caacagggcc aagctcatcc ttcgccactt ccgacagcga ttttccgttt ttgcgcatcg 2562181 atgcaaacaa caccacaata tcatggacgg ctcccccaat taccgccccg attaacagcc 2562241 acaataatcc cggcaaatag ccaaactgcg ccgccagaat tggtccgacc agcggcccgg 2562301 ccgctgcgat cgcggcaaag tggtggccga acgaaaccca tttatttgta ggcacatagt 2562361 ctttcccatc ctcaagcgca tgagcaggtg ttggcttgtc atcattcact ttgagaacct 2562421 tcaccatcat aaatgttccg tataaacgat aggcaatagc caaaatacac attgatgcta 2562481 tcacaattgt aaccgcattc attttctccc atcccctttt ctgtttttca taaatatatc 2562541 ataatttcat ggtgaaaagc ggtcattttt tcctatacaa aaagccggct ggaatgggcc 2562601 ggctcgtggc agttgaaaga caagccggag agaaatctcc ggctttgcta ttcttatgac 2562661 tgttttttca ggcggatcac attccaggaa agcggcgtga aatgagcagt taagccgttt 2562721 tcgctgacag acgatgatcc gttggaatgc ggaacgacat tttttctgtt atgctggttt 2562781 gttgctttga tatcctgatg ctcaagtacg atgtgctctg cgatttggta ggattcaaag 2562841 cctctgagcg aaatctccgt ctccatctga tcctcagcct tgtttaccgc aaaaatagtg 2562901 agtgtttctt cctcttcaga gtacacaaca gcagcatcaa catatggcac atcagtgaaa 2562961 tcagaacaat cgtacttagg agaagaaata agcggtttca gtgactcgcc ccttccgtaa 2563021 acagaagcat gcatgtatgg atagaaaatc ggctgtctcc atgcttctcc gcctttttcc 2563081 gtcatgatcg gcgcgatgac attaacaagc tgtgcaagac acgcaatttt cacacggtct 2563141 gcgtgctgca gcatcgtaat gagcagagag ccgactaata aggcatcttc aaaattgtaa 2563201 atatcctcta aaatcggacg cgcagtgatc cacggctcga cttttttatc agcctcattt 2563261 gagtggtacc agacgttcca ttcatccaga gagagattga tagttttctt gctgcgtgtt 2563321 tttgctttta catagtcaca ggtcgcagcg actgatttga taaaatgatc caaatccata 2563381 gaacgtgcca agtagtttgg cagattgtta tcccggtttc cgtagtaagt gtgaagagag 2563441 atatagtcga catgctcata cgtatgctca agcaccttcg cttcccaatc gataaaggtc 2563501 ggcataccgc tgtttgagct gccgcaggca acgagttcaa ttgatgggtc aacccacttc 2563561 atgacctttg ctgtctctgc ggcaagccgt ccgtattcat cagctgtttt gtggccgatc 2563621 tgccatggtc catccatttc gtttcctaag caccatgttt tgatgccata cggctgttca 2563681 tagccatgcg atcttcttaa atcactccag taagagcctt tcggatggtt gcaatattca 2563741 acgagattac gggcggcatc tatgcctctt gtgccaaggt tgacggccat attgacctca 2563801 gtgttcacct tttttgccca agataaaaat tcatttgttc ccacttcatt ggtttctgtc 2563861 gtttgccatg ccaagtcaag ccgtctcggg cggttttcga ctggtccgac accgtcctcc 2563921 cagttgtatc cggataaaaa gtttccgccc ggatagcgga tgatgggaac ctgtaattct 2563981 ttgatcagcg actggacatc ttttctaaat ccatcttcat ccgcttcagg gtgatcaggc 2564041 tcgtatatgc cttcatatac cgcacgaccc atatgttcga taaacgagcc ataaatccgt 2564101 ttatctactt caccgatttt atattctttg tctacaatca ttcgcgcttt tttcatcaca 2564161 cgtttcctcc ttcattaacc tttgactccc cctaccgtca ggccggagat aaagtacttt 2564221 tggaaaaaca agaaaatgat aatcaccggc aaaatcgcaa atactgagcc ggatataagc 2564281 atgtcgtaat tatttccata agggctcagc aagctggaca gccctattgg aagcgtaaac 2564341 atttctttcg accgaagcac aatcagcggc cacaagaagt tgttccagct gtttaaggac 2564401 tgaaggataa tcatcgcacc gaaagccggt ttcatcagcg gtgccataat cctgaaaaag 2564461 atgccgaatt ccgtacagcc gtccatcctt gcagagtcca gcagatctct tggaaggcca 2564521 agagcatatt gcctgaaaaa gaaaacagca acaggtgaaa cgataaacgg caatatgaca 2564581 cccgtatatg aatcgatcaa gtgcagtccg acagtaagtt taaacagagg aagcatcatc 2564641 acttccagcg gaaccatcat aataatcagc acaagaacaa agatgatatt tctgccctta 2564701 aaatcataaa ccgcaagccc gtacccgatc atcgaagaaa aaaacagagt gagcacagtc 2564761 gtaaaaagtc cgagtacaag actgttaaaa aaccatttga aataaatgct gccgccatta 2564821 aacagaaatg tgtagttatc aaaactcatc acttttggat caatatcaag attcagcccc 2564881 acacgcaaaa gctcagatga cggctttaat gatcctaaaa gcaaacagaa aatcggaaaa 2564941 agatacaata ggctcagcat cataaaaaac agggtcagcg caattctata aacgctaaac 2565001 tgaggactgt gccgcaacat ttatccctcc cccttaaacg agcctgacag ctttaatgaa 2565061 atcaggctga caacaaggat cacaatcaaa agcacaatgc cgatggccgc tccgtatccc 2565121 atttcattgt aggcaagtcc ctgctgatac aaatatccga caagcgtcag accaatatta 2565181 cccggggaat tattctgcca aaggacgtag ctttcctcaa acatcctgaa gccgccgatg 2565241 atgctgatgg tcagcacata tacggttaca ggcttgagaa acggcagcgt gatgtgcaga 2565301 aattttttca ttgtattcgc gccgtctata tcagcggctt cgtacagctc tttcggcaca 2565361 ttttgcaaac ctgctaaaaa gtaaaggatg ttgattccca tccatctcca tgaagcaagc 2565421 agcaccatca aaaacatgcc ggtatgttca ttgttcatcc agttctgagg tgaaaagccg 2565481 agtttaagta ggatggaatt ggccagagac gtttccattt ctccgaagat cagccgaaaa 2565541 atgatccccg cgacaatggt tgaggtcaat gccgggataa ataatgctga tttaaatata 2565601 tttctaaatt tgaccagctt tgaattcagg aatatggcca gaagcaatgg aacaggaatc 2565661 agcacgatca gcgtccaaaa ggtgtattcc agcgtattcc aaagggcggt atagaacgtc 2565721 gggttgttta gcgctgtata attagacaat ccgacaaagg acacctctcc cggcaaaatt 2565781 ctttggaagc tcatgatgaa gacactaatg atggggtata gaaaaaatac gagaaaggat 2565841 aaaacgaatg gcgctgtaaa cagatagggc gccgcttttt ttgaataaaa cagatctcgc 2565901 cagcctgatt gtttcgcagc tgaaggaacg ggatgaaccg ttcccgtttt cacaggtttc 2565961 atgagaacct ccccgctttc actttttgaa tgggattcta tttctgtttc agttcacctg 2566021 ccgctctgtc caaggcttgt ttaggcgttt tttgctgaga tttaagcgcg tcgaacaata 2566081 cgcttctgtt gacaaggtct gaagccttgg caaaatcctc atgtaaataa attggattga 2566141 tttcatcctt gatatcgagc agcacagaaa aaatgcctgt tccgttttgg aagtaatccg 2566201 tgtatttgtt tttctctttc aattccttgg agctccaaac atcccagcga agcgggtcaa 2566261 agccgagtac gctccagagt tttttatttc cttcttcaga gcccttcgca aaggccaaaa 2566321 actcttttgc taactcaaca tgcttggatt gcttcggtac aacagttgcc gtaccgccca 2566381 aacctgccga gcggtcgccc ccctctttcc atgccgggag cggtctgatg gcaatcttcc 2566441 ctttcagatc aggcatataa tcgataaatc ttcccatata ccaaatcggc atgagaactg 2566501 aagcagctcc tccttggttc ataaagccgt agtattcttc actgtgatgc ccgccgcccg 2566561 gcgcaggaat catcgtttta tcattgatca tgtcttttaa atattgaagt gtttttacgt 2566621 tggtgtcatt attgaggatc agcttgccgt ttttatcaaa atagcctgag ttttgctgtg 2566681 aaatcataga taagaacgtt gcggaatcat ttgtttccac cgttcccatc ggcttcccgg 2566741 tcactttgcg cactttctgt ccggctttat ggtaatcatc ccatgtttta atatcgtcag 2566801 gattgacgcc ggcttttttc atcacatcca tgttataaaa catgaccgtt gtccctacat 2566861 gtgtatcgag tccgtaaagc tttccgtttt tgctgtacaa tgtcagccgc gcctcaacga 2566921 atttatcgcg atccttttca atcagcggag tcaagtcggc aagcggtatg tcagagccct 2566981 tcaaaaagtt tgaaaaacgg gccaattcga catctgcaat atcaggaacg ccttctcccg 2567041 ctattaggga gatagataag ttatcgtgca tttgtccata tggataaacg accgtattca 2567101 gcttaatttt gcggtcagga tattttttgt tccattcctt caccatttcc acatagaact 2567161 gctcatgaag cccgttaaat gtccaaaagg tcagctcagt ttcacccgat ttgccggatg 2567221 atttttctgc tgaacacccg gcaatgacta atgtcagcaa catcatgagc acaagaaaac 2567281 agacagtcat ttttttcatc tgcgttaccc cttccattcg aggtgcgggc tattcatata 2567341 gaccatggtt gatcagcgtt ttgttttcat tgatgattct taatccggtg catcggtctc 2567401 ttaaggtgtg cgcgtgtctg aaggcatttt tgacggaatc ctgcccgaca ccgatttcgt 2567461 caaaatacgc agggcctccg gctgatctca gccaatcagc cagcacttct cctctcggga 2567521 gtgtttgata agccgattgg atggcttccc ggcggcttgg tgaaaattcg ttcagcccgt 2567581 catcctgagc gagctttctg tatgtgtcag ttaataaaac agcggcacag cccacctttg 2567641 ccccatgaag aatctgaggc cgttttttct ccattaactc catttcaatc caatgtgaaa 2567701 tatgatgctc gccgcctgat gccggtcggg aatgatctaa tgccagcatg acaagccccg 2567761 atacaagtaa agactccatc aaaacccgta tgccagtttc cgttttcatc gcaatgtctt 2567821 ctgtgtgttc aatgcaggca gcaagcgcct cctgaacgat cttagctcct gcaggcgaat 2567881 aaggctcacc ggcaagatgc cgggatattt cccaatctgc taaagacgtg attttaccga 2567941 gcatgtcacc aaagccagcc gccaccattg actgcggtgc cgcttttaat agatccagat 2568001 cagcgaacag cgcagatggg gccttcgttt gaatggttgt tttcgtgccg tataaaataa 2568061 tcggcgcacc ggctgatgta aaaccgtcta cagatggagc agtcggataa gaaataaacg 2568121 gcaaatctct ttgaaacgcc gcaaagcgga cgatatcatg aatcgtgccc gaaccgactg 2568181 cgatcatgac atccgttggt tgtttcgtat ggatcagcac atgaatgagc gatcgttcat 2568241 cagctgtcac atctccggct tcattttctg gaatgatcag gcactcggcc tgaaatcctt 2568301 cttgattcag tcggttttct aaatcaattc ctgcaatgcg gtgtgtattc gcgtcgcaga 2568361 caaggacaat atgttgattg ttttttcgtt ttacataatc caaaagcgaa tcagctgctt 2568421 gcttaccgag aacaatttct tcaactttta taggcaacgt cttttctccg gcgttttcaa 2568481 aagcacgctg aacgtcagct gcgatacgat tcatatcaga atcccctcct cagccaattt 2568541 ggttacatcc ttaatagaat ccagcacata atccggcgtg tacaaacgct gttcaccctg 2568601 tttcgcagaa ccagttagca ctaaggcgct tttcatgcca taaagcttcc ccatcgcaat 2568661 gtcagattca atgctgtctc ctataatcat gcattcatgt gcggacagcc ccattgctgt 2568721 acaggcagcc tccgccatca gccatgacgg ttttccgaca acaagttcag tcttcgcttg 2568781 tgcagaagtc tcaattgccc cgatcattcc ggccacatca atggcatttc cgtcttcgtt 2568841 cggaaaagag cggtctttgt ttgtagcgat aatacgagcg ccgccggcag ccgcttgaaa 2568901 ggcttgattt aaatcgtcgt acgtgagcgt ttcatgaagg gagatcacga gccaatccgc 2568961 ttccttcggt tcgctcgcgt tctgcacacc ggccagcctc agctcgtcaa ccaagccttg 2569021 ctccccaagc acccatacct ttgaaaaacg ataatgtttt ttcagaaaag ccgctgtcac 2569081 gcttgatgac agaacaatgt cgtttacgtc cgtttcaatc cccgcgccaa gaagtttttt 2569141 tctgcacatg gcacgggaga tattcccccg gttgcttaaa aagacgattt tctttcccat 2569201 tctcctaagc gttttgatcg cttctcttgc tccttcgatc aactcatttc ctctgaatac 2569261 agtaccgtcc aagtcaatca gaatgccagc cggtgacaca ggcgtatcat gactggccat 2569321 aatacgcatt tgctccgtgt tttcgataaa aatgcttttc atgcaggact gtattgattg 2569381 gggttacatc cttgttcagc ataatggagt gataggccat ttcggcaacc gtttctaata 2569441 caactgcgtt atgaatggca tttaaggcgt cagtgcccca gcagaacggt ccgtgattat 2569501 tcacgagcac acccggcacc tgttcgtaat tatgatgctg aaaggtttcc gctatgactt 2569561 ttcctgtatt cagttcgtag tcatgaatga tttcttcatc gtacatttct cgagtacatg 2569621 gaatcgcact gtcaaaataa tcagcatggg tcgtgcctaa cggagggatg tctctgcccg 2569681 attgcgccca gcttgtcgcc cattgagaat gggtatggac aattcccccg atattcggaa 2569741 aggctttata tagataaaca tgggtaggtg tatctgaaga aggtttaagc gagccttcga 2569801 cgacctctcc atcaaggttc aaaacaacca agtcatcggc tgtcaggtcg ctgtattcga 2569861 ctccgctagg tttgatgaca attctttctt tttcacggtc aatgccgctg acatttcccc 2569921 acgtaaaggt taccagctga tgctcttgaa gcttcaggtt ggcagccagc acttcttttt 2569981 ttaatgtttc aagcatgctc catcaccctt tatcaattct ttttggcggc agatgaaaat 2570041 tgaagatttt tgatcgtttt cagacgcttc atgacatggt tttcttttcc gaaataatga 2570101 accagctctt tatattcagc gtacaatttt tcataaaccg cggcgttttc ggcatttggc 2570161 gtataagtta tatctttcag ttttcccatg ttcgccgctg cctttttgat atcatcgtag 2570221 ccgccttttt ctttgcctgc tgcaagcgcg ccgaaaatgg cagatcctaa ggctggggct 2570281 tgcggtgaac cagagatttt aatgtccatg tttgtcacat ccgcataaat ctgcatgaca 2570341 aacgggtttt tctcagctat tccgccggct gcgaacagtt cctcaatcgg aacaccgctt 2570401 tctttgaatg tttcgataat catccgggtt ccgtaagctg tcgcttcaac taacgctcta 2570461 taaatctctt caggcttcgt cagcagtgtc atgccaagca gcatccctgt taaatctgca 2570521 tcaacaagag ttgaacggtt tccattccac caatctaaag caagcaagcc gctttcacca 2570581 ggcgcttgat ggtttgcttt ctcactcagc agctcatgaa cgccaatgtt tttttccttt 2570641 gcttcctctt gataagctgg cgggacacat gttttcacaa accagtcaaa atgatcgccg 2570701 acacaggact gcccggcttc atatcccgca tagcccggga gaattccgtt gtccacaacg 2570761 ccgcacattc ctggaacgat atgcacctct tcaccaagta gaacatggca cgtcgaggtt 2570821 cccataatca tcagcatttt ccctggctct gtaatgccga ccgccggtac cgaaacatga 2570881 gcgtccacat tggcaaccgc aacagccgtt cccgggagaa gccctgtcag ctttgccatt 2570941 ttttcagtca gactgccggc tttttctcct actgaatgaa tagaacctga caatttgtcc 2571001 tttgtaatcg ttttcattga aggatttaat ttctcaaaga aatcatctga cggatacccc 2571061 gctttttcac tccacatcgc tttataccct gcggtacaat tgcttcgctt gagcgagccg 2571121 cacagctggt acacgatcca gtccgcagcc tcgatgatcc ggtcagccgc ttcataaatg 2571181 tgaggcgctt cctcggcaat ttgcatgacc tttggaatca tccattctga tgaaattttt 2571241 cctccgtacc gctgtaaaaa agcctctcct tcttcttccg cgatttgatt gagccgatca 2571301 gcatgttttt gggccgcatg atgcttccag agcttcacat agctgtgcgg ctcctcttca 2571361 tattcaggca gcatgcataa cggctgcccg ctgctgtcaa taggaaggat cgtacatgcc 2571421 gtgaaatcaa ttccaatccc gataatgtct ttcgggtcaa cgcccgtctg ttcgagtaaa 2571481 gacggaatgg ttgtttccaa gacttcgagg taatcagcag ggtgctgcag cgcccagtca 2571541 cgcggcagct tttgacccgt ttttggaagg acggtatcaa tgacagcatg cctgtattct 2571601 tttacagcag ccgcaagttc ctcccctgtt tggacatgaa cgagcactgc tcttcctgat 2571661 aaagttccaa aatcaacccc tattgtgtaa gccatgtgac atccccctct acttttgaag 2571721 ccggtaaagc gcctcgttcc attttaactc gtgtttcagt ttatgaattg tcgtatcacg 2571781 ggaaatgaga acactttcga ttcccgccat ttccgcccaa tcaagcattt gctccgctgt 2571841 cagttcataa gacaggcagg tatggtgtgc accgccggct aaaatccatg cctccgctgc 2571901 tgttttcaat gacggctccg gcttccagag aacacgggca accggtaaat tcggcatgtc 2571961 tttttcaatt tcctggccgt tgacttcatt cagcacaagg cggaaacgcc cgccaatatc 2572021 aacaatgcta gcttgaatgg cagaaccgct gatgccgtta aataccaaac gcgcagggtc 2572081 ctctttgccg ccaatcgaaa gcgaatgaac ctcgattttc ggctgatcca aagcgacagt 2572141 cggacacact tcaagcatgt gagagcccag aatcatttca tttcccggtt caaaatggta 2572201 cgtgtaatct tccatgaagg aagttctttt tcctttagcc atgattttca tcatccgtac 2572261 aagggccgct gtcttccaat ctccttcacc ggcaaaccca tagcctttct ccatcaggcg 2572321 ctgaacggca agtcccggca gctgtttcat tccgtgcagc acttcaaacg atgtcgtaaa 2572381 cgctgtgtat ccgccttgct caagaaaagc ggttaatcca agttcaattt tcgcctgttc 2572441 tttaatggac gctacctttg cttcgtcacg ttttgtttcc tcactgatca catatagtct 2572501 gtcatactcg gcataaagcg tgtcaacctc gtcgtccgta atgcgatcca tcacttcaac 2572561 gagatccccg atgccatatc cgtcaacctg ccagccaaat tgaatatgcg ctcccacctt 2572621 gtctccgtcc gttaccgcga catgacgcat gttatctcca aatctggcaa ccttaatatg 2572681 tctgctttca tttaatgcag ccgccgtatc catccactgg gacatttctt ttttcacttc 2572741 ttcatcatcc caatagccgg caatgacttt tcggctaagc cccattctcg agttgatgta 2572801 accgtactct cgatcgccat gcgcggattg gttgctgttc ataaaatcca tgtcaatcgt 2572861 accccacggg atatcgcgat tatattgggt atgcaaatgc ataagcggtt tttgataaga 2572921 ggaaaggcct tctatccaca tttttgcagg ggaaaatgtg tgcatccatg taatgatgcc 2572981 agcacatgtc tcactgtact ccgcttctct taacagctct ctaatggttt ccggtgaagt 2573041 gacgacgggc ttatgagtga ttttatatct ggaagaaatc ccgctgagcc cctcacaaat 2573101 gcttttagca tgctgatcta cgagttccag cgtctcttcc ccgtataggt gctggcttcc 2573161 tgtcacaaac cagaattcat aatcctttgt ctgaagcatg taaactgccc ctttctcata 2573221 aaataaaacg ctttcaaata caaaagatac gtactaatga tagaaaataa acctataaat 2573281 aaatatttgt acgaacaatt ttattatagt aattgactat tatactgtca atcttttctt 2573341 ttaaaaaaag ccgggggcag agcccggctt tttaattcaa taggacggcc agcccgagct 2573401 ccaattcaaa tcattgatga gaagctttgg aatgccgttg tcattggcat cataggcatg 2573461 gcgaacaaga atgtttccgt tcacaatatc ctggcctcca ggtcctttcc attggtcatt 2573521 gcccgaatcc aaaatggtgc ctccgccttc aagcatgctt tttccgcttt tatcaagata 2573581 agggcctgta atgcttttgg atcttccgta agcaattttg tacgtactgt ttaccccgtc 2573641 acagcattta tcaaatgaaa ccattaaata gtaatatcca ttttgatacg taagagtagg 2573701 agcttctaag gcacctccat tattcggtct agctgcaatc gaatagagcg agcctgtagg 2573761 cttcattgta ctcttatcga gcttagtcag cttaatgccg ctccaaaacg agccgaatgc 2573821 aagccacggg ttgccatcct tatcgaatgt cagctccgga tcaatggcgt tataattatt 2573881 tgagcttgtc gaacggatca ccaagccctc gtccttccag ccccccgaac tgatgcttgt 2573941 tgaagatgcc aggccaatgg cagatgtatt gcttccaaaa gaagaaacgg aataatatag 2574001 ccagtacttg ccgttatagt attggatgtc cggcgcccac tggttttggc cataattcgg 2574061 cacataattg gaccaccacg atagcggtgt agtgaaaatg gatttttgta cggtccaatt 2574121 tttagcgtct gaagacttca aaacccgcag tccccgttct tcagtaagcc ctgttccgag 2574181 cgcataccat gagctcccct ctttaatcat agtcgggtca tgaagcagct cattggatgc 2574241 accccaaaac gctgcctctg cgggagcagc agaagtgaat atcaaacctg cagccagagc 2574301 tgcactcgaa aagtgtaaga agcgtttcca tgtttttttc tttttcaatt ttgttcaacc 2574361 tcctttattt tagaaagcgc ttacaaatta gattatttat cctcccttcc tgtcaaatcg 2574421 actgcgtatc gtatatcgtc atgttcagga aattttcggt atccccttta ttgtagtcac 2574481 tatgctgtaa tttgtacaga caaaaaaata gaatccacct caataggcgg attcttccgt 2574541 atctttattg gtacgtaatt tcgtcaaccg tttttcggtc taacttctta atgacttctg 2574601 taattaactt taccgcgttt tcataatcat cacgatgcag catggccgcg tgcgtatgaa 2574661 tgtagcgggt tgcaatggta atggacagcg caggaacgcc atttgccgtc aaatggatgg 2574721 cacccgaatc agttccgccg ccggcaatgg catcaaattg gtacggaatg ccggcttcct 2574781 ccgcagtggc tacaactgca tcgcgcaaac ctttgtgaga gaccatggat gcatcgtaaa 2574841 cgataatctg cgggcctttg cccattttgc tctgcgcttc cttctcggaa atgccaggcg 2574901 tgtctcctgc tatccctaca tcaacaccaa acgcaatatc aggctgaatg gtgtgtgcag 2574961 ccgttttcgc tcccctcagc ccgacttcct cctgcacggt tccgacgcca tacactatat 2575021 ttggatgatc tgtgttttgt aagtttctta acacatcaat agcaatcgca cagccgatgc 2575081 ggttgtccca ggcctttgcg agtaggaatt tttcattgtt catgaccgta aattcaaaat 2575141 gcggaacgat catatctccc ggaagtacac cccactccaa ggcttcttcc cggcttgaag 2575201 ctccaatatc aataaacatg tcttttattt ccactgattt ttttcttgct tcaggagaca 2575261 aaatatgagg cggcttagat ccgataaccc ctgtgatttc tccttttttt gtgacaatgg 2575321 tgacgcgctg agcaagcata acctgagccc accagccgcc aacggtttga aaacggataa 2575381 agcctttatc tgtgatttgt gtcaccataa agccgacttc atccaaatgt ccggcgatca 2575441 taattttcgg gccgttttct gcaccagttt tttttgcaat taaactgccc aggcgatctg 2575501 ttgtcacctc atcagcaaat ggttctatgt atgatttcat cacttgcctt acttctcttt 2575561 cattgcccgg tatgcctttt gcatctgtta aatctttcag catggtcaat gtttcatcta 2575621 attttgccat gttccaaacc ctccttcatc agtcctgcat tcttattata caaaacatgg 2575681 cgctaaccat acgactattt cacttgaaaa tcgggtatat gtttttacag ctttctttta 2575741 gaaaaagtga aacctttttc tatgcttttc gtattacatc agatcatcac cataagggag 2575801 gtgccttcac acaatgtttg tcatggttct aaggattatt ttgcttgcac tttttgctta 2575861 ttgtatttat gccgtggtca aatatgtcgc gaatcctaag agaaggctta agctggccca 2575921 atcaaaagaa catttttata ttattgatga acaaaacaat acccggaaga attttcagct 2575981 gacgtataaa ggcgtgcttt ttgagggaga aaagcatatt ccttccaagg atcatccgct 2576041 gtttattcac acgatctttg tctggacaga atctcctgag aagctgaaac atttctctgc 2576101 aaaagatttt gagaacattg aagaaaaagt gctggaacga tatccaaatt gtaagattga 2576161 ctgggaccag cccattaaac tcgcaaaaaa agcagaagag cgttaaacgc ttttctgctt 2576221 tttataaatc aaacgggctg tagtaaatag cgatgagaat cgcttctatt accagaagaa 2576281 gcggtactcc gtacttaaaa gaagcgtgtt tcgttttatg tctgaaggtt tgcatgccaa 2576341 gccagacacc gagcgctcca aacacgatgg ctatcagcca cagccggtct tcagaaattc 2576401 tccacttgtg ctgctgcgct ttgcgtttgt caatgcccat cacccaaaaa ccgcacagat 2576461 taatcaacac caaataagca gcaataatca tgttgcctca tcctttatat agaaaaagcc 2576521 gctctgctgg agagcggctc tatatgatta cttgtttaat tgagctttag cagcatcagc 2576581 aagctgattg aatgcagtaa gatcgtttac agcaagatca gcaagcattt tacggtttac 2576641 ttcgatacca gaaagcttaa gaccgtgcat taaacggctg taagaaaggc cgttcatgcg 2576701 agcagctgcg ttgatacgag tgatccaaag tttacggaaa tcacgttttt tctgacgacg 2576761 gtcacggaaa gcatagtttc cagatttcat gacctgctgg ttagctactt tgtataatgt 2576821 atgttttgaa ccgaaataac cttttgctaa tttaagaacc tttttacgac gcttacgtgt 2576881 aacagttccg ccttttactc ttggcattga atttccctcc taattgttcc ttatccgatt 2576941 acttgatgtt agcaagcatt tgtttgatac gtttgaagtc tcctgcgctt acaacagcac 2577001 tcttgcgaag cttacgcttt tgcttttgag atttgttggc gaataagtga cttgtgtacg 2577061 cgtgagaacg ttttaacttc ccagaacctg tctttttaaa acgtttagca gatccgcggt 2577121 gagttttcat ttttggcatg ggatttcctc cttattgctt ttcgtttttc ggtgcgagca 2577181 ttaagaacat gctgcggccg tccatttttg gttttgtttc gactgtcgca acctcagcac 2577241 atgcttcgga gaaacggtct aatacacgct gaccgatttc tttatgagtg attgcgcgtc 2577301 ctttaaagcg gatagaagct ttcactttat cgcctttttc aaggaattta atcgcattgc 2577361 gcaatttcgt gttaaagtca tgctcatcga ttgtcggact taaccgaact tcttttaagt 2577421 taatgatttt ttgattcttg cgtgcttctt tttccttttt ctgctgctca aatcggaact 2577481 taccgtagtc catgattcgg cagacaggcg gttttgcatt cgctgcaact aacacaaggt 2577541 caagatttgc gcggccggcg atttcaagtg cttcctgacg ggacttgatt ccaagctggt 2577601 cgccattttg tccgattaaa cggacctcac gtgcacggat accctcatta accaattgat 2577661 ctttgctaat aatgagccac ctccatagtt tcttcgaatt gattcacaac tcattttgaa 2577721 tgcattttgc aggcaaacaa aaagtgtggg cattataaaa cacccacact acgaacatct 2577781 gtatcaataa aaatgtacgg tcaacctgcc aactacatgc atgtgtcaat caggtgagaa 2577841 gcgggtgctt ctgcttgtga tttatattca attcaataac tattctacac aataccggat 2577901 ctttagtcaa ggacgactta tccggaacaa cttttacatt gtaacatggg ttttctatga 2577961 gcgcaagaga gaaaaagaaa atctttcatc cccacccaga atacaaagaa ccaacaattc 2578021 ccccttatta cgcaatttac aacaaaacca ccgacaggaa gaaatgtaaa acaaagttaa 2578081 tctctgaccg atataaggag cagaagggag cctgacacat gaacaaactg atacagcttg 2578141 ctttattttt cacattgatg ttaaccggtt gctcgaatag cagcacatct tccgaatcaa 2578201 aagtcgaaac cactgttaag acaacggcag catttcctca aaaggagctg gagaaagagc 2578261 taaaaaaact aaaacccgtt tcattggaca tgaagttcga gagtccactc gctaccgagt 2578321 taggaaagcg gaaggcaaaa gaggaagctg aaaagcaaag acaaatcgcc gctgagaaaa 2578381 agcttgaaaa agagcgggag gcgaaacgaa agaaacagca ggaggaaaaa gcggagagac 2578441 agcgattagc agagcagcag gctgcagaga gacagcgatt agccgaagcg gaaagacaag 2578501 ctgaacttga aagacagcgg caggcagcaa tccaaaaaga gcagaaagcg aacgctgaga 2578561 aaaagcggca atcgcaggca caacggcagc agactgaggc accctcatct aatagtcaag 2578621 atccaccatc ttcctcgagt cagacagata aaaccattca acagccagct tcagagcttc 2578681 ctgatgacga tggttatggt tatgaagaac gaaaaaagtg gcatgacgat caagtagaat 2578741 ggggcattaa acaagggtat atcgatcccg aagacgcacc ataaaataaa aaaagccaag 2578801 gcattcagcc ttggcttatc ctccgatcag ctgcacgaac acagggatga ccagaaccgt 2578861 taccactcct actacgacaa cagcaatact tgccatcgca gcttcaactt ctcccatctc 2578921 aatcccgacc gctacaccaa gtgcatgtcc ggatgttcca agagccaatc ctttagaaat 2578981 cggatttttc actttaaaca ccttcaagaa caatgctccg agcgcatata cgatgacagc 2579041 gttaaagatg accgcaaagg ctgtgatgtc gctgatgccc ccgatgcctt ttgataaagg 2579101 aagcgcaatt gccgttgtag ccgcctgcgg aagcatgctt ttcattacgg ccgaatcgag 2579161 atgaatgcct ttagcgagca gataaacaat cgtgacagag cagatagagc cggcaataat 2579221 ggaggccatg atttgccacc agtacttttt aagcttatct ctttgtttgt acaaaggaat 2579281 tgcaaatgcg atcgttgccg gttcaagaaa aaacttaatg atctctcccc cgttattata 2579341 atccgcgtag gaaaaaccgc cgatttttaa aaatgcgatc cccagcacca tggcaacaaa 2579401 caaaggagtg aaaaggaaga agcctttcgt tttcttaaat aaaaaggtgc cgatgccgaa 2579461 tgcagcaagt gatacgacaa tcccaaaata aggactcatt gtgctttcca tgtgaagaac 2579521 ctcctgtttc ccttaatggt gaacgagttc gttattgttc tgcgggcttt gcactgtttt 2579581 tgttttcatg tccgcttcgg ttttgcgttt tccgctcagc gacagaatca gctgagaaaa 2579641 caatcccgta gcccccagca aaataatcgt tgcgagcaga atgacaagaa caatttgcag 2579701 gccgtattgc tgcatcacac caagcgaatt cataacagat atacctgatg gaacaaataa 2579761 aaatccgatc agagaggtta aagacgttcc gagcgtctcc acttgttcca gtttaatgac 2579821 tttcaaacat aataggagaa ataataagac caaccctaca accgatgccg ggataggtat 2579881 tgggacaata gcggcaatca tatttgaaac cagcataatg acggcaaaaa taaatgcttg 2579941 tgttaaaaac ccgtacactt ttttagcact cattttcttc acctctttct ctttggtacc 2580001 ctcattataa ataagaattc cctgttataa agcgcttaca agataacatg ccgtatagcg 2580061 ggtctgagtt gcagaatcaa atggctgaaa tgcaaaaagc cgcccatcaa atatggagca 2580121 gctttttcaa ttccttcgca tatgtccggc tgaccggtat tttcgatccg tctttcatga 2580181 tcagattata cgttgaatta aaccatggct gaatttcttt aatatattca gtattcacga 2580241 caaagctccg atggacgcgg ataaaatcag aatccggcag ctttttctca atcacaacga 2580301 gtgtatcgct gaccgtataa gaatgatcga aggtttttac attgacatga ccatcttctg 2580361 ttccggcata gataatgtcc ttcgtatcca caatcacaat cgattccccc acagatagcg 2580421 cgagcttgtg ctggccggca tggctgtttt gctctgtttc tacaatatcc cgattgactt 2580481 ttttatattt tttcagcgtt tgctgaattc tttcttcatc gaaaggcttg gttaaataat 2580541 caagagcgtc cacctcaaac gctttgagcg catactggtc atacgctgtc gcaaacacaa 2580601 tagcaggagg atgcttcatt ttcttcaatc gctttgcgat atcaaaaccg ttttctccgg 2580661 ataaatcaac gtctaaaaac agcaaatcag gtttttgatc catcatttgg tcaaaagcgg 2580721 attcgatatt ttccgcttca ttgatttcca tttcatcatt ggtccgctta agcaagtaag 2580781 ccagttcatc ccttgccagc atctcatcat caactattaa caccctgagc atgttcttct 2580841 ccctctttca tctgttgcat tggcacttga aaggaaacct ctgtcccttt atgaacctca 2580901 ctgctgatat gcagtgcagc ctgctgtccg aataaaccga tcagccgctg atttaggtta 2580961 taaagcgctg taccggttcc ctccttagac ggaaacggtt tcttccccag ttccggcaag 2581021 acgtccggcg gaattccgcg tccgttatcc gccaccttca tatagacgga tgcatcatca 2581081 gataagacac agactgtaac cttgcatatg tcttgttttt tcggaaacgc gtgccgaagc 2581141 gcgttctcga caagcacctg caaaacaaac ggagggattt caatctgctc cagtctgctg 2581201 tcgatattaa gctcaatttt atatttcccg ggaaaacgcg cctgttctaa tgacaaatag 2581261 gcgttaagat ggttcagctc ctttgagagc ggaatcagca gctgtctcgc tccttgaagg 2581321 tttgaacgaa aataaacact gagctgcaat aggagcttac gggttttttc aacatctgta 2581381 cggcataacg cagaaatcgt gttgatcgca ttaaataaaa aatgcggatt cacctgtgct 2581441 tgaagcgctt taatttcagc atccttgaga agtttgcttt gcagctctgc ttccccaagc 2581501 tcaagctgtg tcgaaaacag catggccagc ccctcggcaa gttcctcctc tacctgactc 2581561 aggcctgccg ggcttttaaa gtacattttt aaggtgccga ttgtattgcc gttcgatgtc 2581621 agcggtagga caattgcagc gtgcaaaggg cattcagcat gcgtgcattc aatctcttcc 2581681 tgcgaaatcg ccttcataat atgccctgtt ttaatcacct ttttggacag gccggtgatc 2581741 aagcttttcg atgggatgtg gtgatccatt cccgcaccga catgcgcaag gatcttttct 2581801 ttgtcagtga gagacaccgc atctgttcct gtcagcttat ggataatagc cgctacactt 2581861 ttacaggagt tttcatttaa tccttggcgg aaaaatggaa gtgtctgatc agcaatcgta 2581921 agcactcgat gcgtttcgag agcccttgcc tgttcttcct tgcgaatgat cgcttgaata 2581981 atagacagaa aaataaaact gcctgttcca ttgatgagta tcatcggaat tccgatcatg 2582041 ctgacaagct cccaagcgtc actgaacggc tttgccatca gcaaaataat gatcatttgc 2582101 agtgactcca tgccgattcc cacaagagcg gcgatgcgcg gtgtcggcat tcgatatcgc 2582161 ttcgtaaaat acctgccgat caagcctgca agaacacccg ctaaaataga tgagacggca 2582221 cagcttaagg ccgtgctgcc accgagtgaa aaacgatgca ggcccgcaag tatgccgatc 2582281 ccagccccta caaaaggacc tccgagaagg cccccgattt ccacgcccaa aatacgggta 2582341 ttcgcgatag agcccgatgg atctatcgta aacacccagt cattgtttac aatcatattt 2582401 ctttgaattt cgatgcctgt ataattgctg atgatgctga aaagagaaaa aatagaaatt 2582461 aaaatcgctt ttcctttata gccgtcctga ttctgaagag cttgtctgaa aagtttcgta 2582521 tgggcgagaa tgaaccctaa tataacaata atccccactc tctccagcat cataatcatt 2582581 aaatgaatca ttcatgtcac ctgttctttc cgttttcatt ctagcatgtt ttcgttttgc 2582641 ggctgactgt ttttttaaaa tcgtctgaaa acatatttca caaggctttt atctattgta 2582701 aaataaaaca tgagcctttt ggcagaaaga tttgaatctg aagcagagga gaagatcatg 2582761 aaagccgtat tttttgattt agatgataca ctactttggg acgaaaaaag cgtcagaaca 2582821 acatttgcag aaacttgctt acaggcggag aaaaaatatg gccttgcccc tgaggaattc 2582881 gaagcagctg ttcgcgaagc ggcgagagaa ttgtacatgt catatgagac gtatccatat 2582941 acagtgatga tcggcattaa cccgtttgaa ggactgtggt ccaatttctc agagccaatc 2583001 agtgaaggct ttcaaaagct gaacaagatt gtgccggagt acagaagaaa tgcatggacc 2583061 aacggactga aagcgcttgg gatcgatgat cctgcatatg gcgaatactt gggagagttt 2583121 tttgcggcag agcgcagaaa gcgcccgttt gtatatgatg aaacttttgc tgtactcgat 2583181 caattaaaag gcaagtatga attattgctt ttgacaaatg gcgatcctag tctgcaaaag 2583241 gagaagcttg ccggcgtgcc tgagctcgct ccttacttca atgaaatcgt catctcgggc 2583301 gcattcggca agggcaagcc ggatgtttca atttttgaac actgccttaa gctgatgaat 2583361 attgaaaaag acgatgccat catggtcggc gataatttga atactgatat tttaggcgct 2583421 tcaagagccg gaatcaaaac cgtttggatc aaccggactg ataagaaaaa cgaaactgac 2583481 gtaaagcctg attacatcat cagcagcctt catgatttgt ttcctatatt agagaaataa 2583541 aaaaagcatg atctcttcaa tgagatcatg cttttttatt ttattttttc gcttcagcta 2583601 ctgccttttt cacaaactca tcaagtgaaa tggtttcaga gttctgttct ccgtatttac 2583661 gcacgtttac cgctccgttt tctgcttctt ggtcaccgac caccagcatg tacgggattt 2583721 tttgcatttg cgcttcacgg attttgtagc cgattttttc atcgcggctg tcgacttcaa 2583781 cacgcaggcc ttcacattgc aggcgttcct gcactttttt cgcgtagtct aaatgcacag 2583841 ccggagaaac cgggatgact tggaactgaa ccggtgcaag ccatgtcggc agcgcgcctt 2583901 tgtgttcttc gattaagaaa gcaacaaagc gttccattgt tgaaacgaca cctctgtgaa 2583961 tgacaaccgg acggtgctgc ttgccgtcct caccgatgta tgtcaggtcg aaacgttccg 2584021 gcaataagaa atcaagctga accgtagaca gtgtttcttc ttttccgatc gcagttttca 2584081 cctgaacatc aagtttaggt ccgtagaatg ccgcttcacc ttctgcttcg taatagtcgt 2584141 ggccgatttc atccattgcc tctttcagca tggattgcgc tttgttccac atttcatcgt 2584201 catcaaaata tttctctgta tcttccggat cgcggtaaga cagacggaat gtgtaatcac 2584261 ttaaaccgaa gtcttcataa acatcctgga ttaaacggac tgtacggata aactcatcct 2584321 taatttgatc cgggcgcaca aagatgtgtg catcatttaa cgtcattccg cgtacccgtt 2584381 gaagtcctga cagcgcacct gacatttcat agcggtgcat cgttccaagc tctgcaatac 2584441 gaatcggaag ctcgcggtaa ctgtgaatgt cttgtttgta aatcatcata tggtgcggac 2584501 agttcatcgg acgcaataca agtgtttcat tgtccatttc catcggaggg aacatgcctt 2584561 cctgataatg atcccagtgt cctgatgttt catacagctc tttgctgcct agcacaggtg 2584621 tgtatacgtg ctcatagccg aggctgattt ctttatcgac aatgtagcgc tcgatgacgc 2584681 ggcggattgt tgcgcctttt ggcagccaaa gcggcaggcc ttgtccgact ttttgagagt 2584741 tcgcgaacag ctttaattct ttgccaagct ttctgtggtc gcgttctttc gcttcttcta 2584801 gcatacgaag atgctcttca agatcagctt ttttgaagaa agctgtacca tatacgcgct 2584861 gaagcatttg gtttttgctg tcaccgcgcc agtatgcgcc tgcaaggctt aacagcttaa 2584921 attctttgat ttttccggtt gaaggaacat ggacgccgcg gcacaggtca aagaattcgc 2584981 cttgctcata gatcgaaacg gtttctcctt caggaatcgc atccaatagt tcaagcttca 2585041 ggtcgtcgcc gatttccgca aaacgggctt tcgcttcttc acggctgact tcttttcgaa 2585101 cgatcggaag gttcgcatta acgatttttt tcatttcttt ctcgattttc ggcagatcct 2585161 ccggtgtaat cgcttcgtcc atttctacat cgtagtaaaa accgttttcg ataaccggac 2585221 cgacgccgaa tttaacatcc ttgtagatgc gtttaatcgc ttgagccagc aagtgagccg 2585281 cactgtggcg cataatttga agaccttctt ctgagccttc tgtaatgatt tccactgtac 2585341 cgtcttcatt gatcggcgtt ctcaaatcga tttcttttcc gttcagtttt ccggctaatg 2585401 actttttctt taatcccgga ctgatggatg ccgcgatatc ttctgttgtt gttcctttcg 2585461 caaactcctt gactgctcca tcaggaaatg tgatttttac catatctgac atctttgtca 2585521 ctcctttttt tgcatataaa aaccccgccc cctatgaaag ggacgaggtt gaataaacgg 2585581 aatcgtggtt ccaccctttt ttccgcaaag ccaatacacg gcacctgcgg ctctaagctc 2585641 tgtaacggga gttcccgtca gccattactg ttccttttca agaggttcac agctgaagtt 2585701 caaaggcggt aaagcgaatg gtccttagct gggaagcttg cagccagggc ttccctctct 2585761 ttgagccggt atcattcctt cgtgtcctta tcaatacgtg tgtctttctt aatctcctat 2585821 gtattataaa ttgttcaatc caaaaaatca acacgatcgc gtttcctttt ttttaaaccg 2585881 acagccttaa atagacaggc tgccggccct catccttccg agtgcttcac cggtatttct 2585941 gcatctgtaa aagcatgcag cgggagcatt tccactctct cttgaaatac gttttgaatg 2586001 gtccttgcca tcatgtgctc gggctggtcg gtataaagca cgacttcatc aggcgcaatg 2586061 gaaatcagcg gcgcgagcaa atgagaatca atatacatag gatgatcccg gacaaatctt 2586121 ctgtctatgt atttcatttt ttcccgttcc ggcacatagc gcagctccca taatgtaaag 2586181 gaaccatcat ggacaatatg cacttttttg attcgcggct gtttggcgtc cacatagtct 2586241 ctgagtgttt gaataaagtt ttgatattcc tgttccatct tatattcatc aatcgctgct 2586301 tctgtaatat ctctcagctg cttatagtat gatccaagtc ggaaggtctg aaaggagcga 2586361 atgtaaaata ctccttcctc taaacagatc gtttggagtt catccaaaat tgattgtttc 2586421 cgtgaaagct tcagcggctc aaacggaaga tcgtctgctt caccttcaat aatactgtgt 2586481 gcgagctgaa ggatttgctg ctgttcatcc tggtccgtga aacaatacgt ttcctcaatc 2586541 aatgacagca tatgctcgtc ttctttgcat tccaaaaaaa atttgaccag aatcggctcc 2586601 ataaaacgct gaataggaaa agccggattc gctttttcaa tcccgatttt tcgtatgcct 2586661 tcacggacaa tgatattgtt ccgatcgtcc gaatgctgaa tgagatgtaa aaaagcggct 2586721 gcatcatggt catcttcaaa gattatttca agcatgtttg tcccccctta cggcatctgt 2586781 tacaagtata tgggggatgt ttttaaaata gacgtaaagg tcattggcaa atcttaattt 2586841 gattcttgga acaagttttg cattttcttt ctgaagatga acggcaatga gataaacacg 2586901 atatacaaag cgagcaccat aaagaaagcg ggcagattgc cagccaaaaa gctcgcaccc 2586961 agcacattaa gcgcaatcgt cccagggatg attcccacag ccgttgcggc aaaatacggc 2587021 agcgctttga cattggaaag gcctgccgca tagctgacga aatcaaaatt gatcggcagg 2587081 attctcaaaa gaaagatata gaaaaatccg ttatcctcca tttgcttctg tatggcttca 2587141 agcctttcgt aatgcccgtt ctttttcgcc gaaaacaaac cagccgcaaa aaacgaaaca 2587201 gctgaagcgc acatcgaacc gaataacgta taaagcgtgc cgagaagcgg gccaaacgca 2587261 agtccgccag ctattgaaat aacagacacc ggaaataaaa caagtggcct gacgatggat 2587321 atcccgataa acatcagagg tgcaaagact ccgaacgaca atacccatac cctgatttct 2587381 ttcggcgata cattcaaata cgttttattt ccccaataga gtaaaccagc acctgcaagc 2587441 actgccagcc atttgacagc cgtttttcgt ttcataccct cagttccttc ccctttgaac 2587501 cacagcaatt atggatgtcg gcggttttct ccgtcaaggc ggatcggagc agccaaatat 2587561 aatatccgct ccattaatct tgcagctttt acttcttctt tttctcccct ctgcgaatac 2587621 gtaaaatgat gcttcagctc gtcaggtgag aaattagaag aaaagaacgt tggcagctgc 2587681 tgggacattc tgtgctgaag caccgttccg atgacctcat cccttaccca gcttgtcatt 2587741 gattctgctc cgatgtcatc aagcattaat acgggtgtgg tctttaccat attgagcttc 2587801 tcttccaatg tctggtcttg cagcgaattc ttaagctctc tcacaaattc aggcacataa 2587861 acaatcatgg aggaatactc tttttccgcc agctcattgg caattgcagc gagcataaac 2587921 gtttttccta ccccaaattt cccgtataaa tataatcctt tcccttttcc cgtctcatta 2587981 tagcttttca ggaagtctgt aacatgctga aacatcgcga gtctgcttgg gtcactgata 2588041 tcaacttgct ggaacgtcgc tccaagaaga tcctgctgga tatacatgct tttcataaga 2588101 gactgttgtt tcttctgctg gtcgagcttc cgtttgactg gacattcgta atactcgata 2588161 tcaatagacc tcccattgac aacaagcttc ggatggtagc cctccaacaa attgttgcag 2588221 ttttcatctt ccgaacaata ggagcaattc ttgctttgtt cgatatattc ataaagctta 2588281 tttaagctct tttcgatcat tttttggtca atcacttctt cgttttcctt caaaaatgct 2588341 tgaacatctt gatctttcat gactttttcc ttcatttgtt caagacgttt ttggaaatcc 2588401 ggcctgccgg ttacgccctg cagggaacgg ccgattggtt ccatctattc cttcaccccg 2588461 catctctgtc tttaataggc agagtatttt ttcagttttt gcatttcttc catcatcttt 2588521 ttcttctgtt cttccaaatc ctgcggatgc agcttctgct gtccggattc tgaatcggac 2588581 gctgtttcct tttctgtcat ccaatcagga agcttttctt cacgaatcac tttttggttt 2588641 cgtttcgaag actttgtttt tccctcagcc cattcaagat actggcggtt ttcttctatt 2588701 gcgagcttca tcgcttccct gaccgttttc acctttttgc gtgcccaatg cgaagcgatt 2588761 ttttggatat agtttttcga cagcttcatg tcggttttca gcatgacata ataaattaac 2588821 acatttgtga cgcctggctc gagcttctgt tcgaacataa tttcttctat gatcttcaga 2588881 tcagcttttg acggctctgt tccgtcagca atgtcctgca gaagcttctt cggggaaatc 2588941 gcctccagca atgcaatcag cttcccatcc agagaatcct cttctgccgg ttgttcgcct 2589001 tcacgcagat gcaccggctg tgttttttcc accaaatcgg gcagctgtcc gtttctttca 2589061 atttgatacc agtcgctcgc cgcttttctt aatgcctccg tcgtaatgac gtcacgctca 2589121 tcaattgcgc tcatcacaac attttgcatt tgcaaagggt caattccgta cagataagaa 2589181 agctttttga ttgtgtcccg cacctgctgg gtcatcgctt ttctcggtat catcgtctca 2589241 gaaagtcccg ctaaaaacaa atcaaaatca aacacatcct ccgttatggt gtaggacgga 2589301 gactgtccga cagaagtata ctcggacccc tcggcaagcc ttaccgtttc ctccatatcg 2589361 gatgtgagct tccattcact cggctgcagc gattcaaacg catgattaaa cggacgcgta 2589421 atgtccttcg catcttctga aatggccggg tgcgtaaaaa attgttttaa ttgctgatat 2589481 ttcgtttttc cgaccctatt atacagaaaa acattcagca ttccgtcttc aaaaaattca 2589541 tttggtctga gcggcggaag gagttcatat ataaagaggc gctcctgccg ctcggattct 2589601 ttcatatata ctttcagcaa tccgatgccc tcgagcttcc cctgttcctg atggatcgtt 2589661 tttaagttgg actgtgtcat ccccatcagc tgtctatgtg tggactctcc gccccacaga 2589721 cggttttgtt caagctctcc ccacaatgtc atataaagag agaatgcaac agggccgatt 2589781 aagggctggt acagttgtgt aataatttgt ctgtcaatat cctgcagcat cgatctgctt 2589841 ttaaccacat acgggtctac aggcagtaca tctttccaat agtcagccat acattctcaa 2589901 accttccgaa tttgtttcta cctttcattt tacaccgttt cttatatcta tcaaatgcca 2589961 attttgcaca tgagaaaaga gctagaagaa tcctcttagc tcttttaacg ctctttcttt 2590021 attaagtctt ttaattcatc gataaagacg tttatatctt taaactgccg atagacggac 2590081 gcgaaccgca catatgcgac ttcgtcaatc ttagccagcc ggtccatgac catttctccg 2590141 acgagctcac tcttcacctc ggagcagcct tgattgcgaa gttctttttc aatatcaaag 2590201 cacatgtctt caagcgtttt gagtgaaaca ggcctttttt cacatgcttt tatgaggccg 2590261 cgcagcattt tttctctgct gaattcctca cgcacacctt cttttttcac aacgatgagc 2590321 ggggtttcct ccactttctc aaaggtcgta aaccggtagt ggcaggattc gcactcgcgt 2590381 cttcggcgaa tcgactttcc gtcatccaca ggccgtgaat caaggactcg tgttccgtta 2590441 tgctggcatg aaggacattt caataaaatc agctcccaac tatatcgttc cctgcaatgt 2590501 attttcggca gcctccgcct tttaaaaata gatgtgacag catctgtcgg gagagccgtt 2590561 gttaaatttg tttctatagc attaggtggt ttgtgaaaat ctccttctta ttttacaaaa 2590621 aaaatgaaaa aagaaaaagc tgacactctc gtttctttat aaaaataaaa ggagcataag 2590681 ctaaaaagcg cataatggct ttctagcttc agctcccttt gtgttcgcaa tttactttat 2590741 agtactttcg cttgcgcctg tttaatttgc acaggcccca ttcctcttgg tatttcaatg 2590801 ttttctcttg tatcagcatg taatgcctct gcaatgtaat cagcagcgac attaggatct 2590861 aagtctccac aagtataaac atcaatgctc gcatatccgt gctcaggaaa actgtgaatc 2590921 gttaagtgtg attcagaaat aatcacaact ccgcttacgc cttgcggtgc aaatttgtga 2590981 aatgcaacct cgcgcacctc agcacctgat tttagagcag catttacaaa cgttttttca 2591041 ataaaatcca tgtcattcag cttatcaaaa tcgcatcccc atagctcgga gataacgtga 2591101 cgccccattg tttccatagt catggacccc ccttaacaag aattaaaaag tgaaattcca 2591161 acaactgggt cggccattta ccacggggga aagttagtcc ggagaggtcc taacccttta 2591221 agtaattccg aaacagtctc aagcaagaag ttcacgaaaa atagtatact gtgtttaagt 2591281 ctaatttgca aggtgcgttt tttcagaaat atgctgttaa gggttttttc tttaaaatgt 2591341 gtccatgacc ttattttata cagcagacgg atgtttcatt cgtgccgcta catggcggat 2591401 tagatcaaca actctgcagg agtagcccca ttcgttgtca taccacgcca gcacctttac 2591461 tttcctgtct tccattacca ttgttgtaag cccgtcaatg accgctgaat gcggattcgt 2591521 attataatca gtcgaaacga gcggttcatc tgagtaatca agtacaccgt acatcgacgt 2591581 tttggcagcg cgtttaaatg cctcgtttac ttcttcagcc gtaacatccg ttttcagatc 2591641 aacaacgaga tcaaccaatg agacgttcgg aacagggaca cgcaaggcga ggccgtgaag 2591701 ttttcctttc agatgcggca gcacaagcga aagcgccttt gccgctcctg ttgttgttgg 2591761 aatgatggat tcaccgcaag cccgcgcccg gcgcaaatct ttgtgcgggt tatcaatatt 2591821 tttttggtca ttcgtatacg catgaactgt agtcatcaga ccgctctcaa tgccaaactc 2591881 ttcatccagc acttttacaa caggcgcaag gcaatttgtc gtgcatgacg catttgaaat 2591941 aatgacatgg cgctcagcgt cgaattggtc ctcatttacg cccatcacaa tggtaacgtc 2592001 ttcatttttt cccggagcgg tcaaaatcac tttttttgca cctgcttcta tatggcccat 2592061 cgctttatct ttagcattaa acttccctgt tgcttcgacg actatgtcaa tatcatattc 2592121 ccgccaaggc agctgttttg gatcacggct gtttaacaaa agcactttct ttccatttac 2592181 gatcaggcta tcttcaccag ccacaacctc tttgtcgtat ctgccgtgaa ttgtgtcata 2592241 ctttattaaa tgagccagcg tttctgcgga atagctggcg ttaatggcca ctacttgaat 2592301 ttgatcgtct aacatcgctt ttctaaaaac cattcttccg attcttccaa acccgttgat 2592361 cgctactttt accttcatgt tggacacccc ttatcaatta tgccatccta atttgttact 2592421 atctaaaatt agtataacac attaaaacaa attcgccagt acatattgat aaaaatcaac 2592481 gattataacg ctaatttatg atgcatctta tgttttcttg cacagaatat caggcgtaag 2592541 aaccaaaaag cagccagcgc tccgcactga ctgccctcat gctttatgat tcctgtttta 2592601 acttatcatt gagcacactt tcttctagca cagaaaatgt atccccgtac actctgttaa 2592661 tatgattcgc tccccaagca cacagcatat ctaaaatccc ttctaagctg cggccgtatt 2592721 cgctgagctc gtattccact ttgggaggaa cttgattata tacgattcgg ttaatgacac 2592781 cgtccgcttc cagctcgcgc agctgctgag tcagcatttt ttgcgtgata ttgggcatta 2592841 ggcgttttaa ttcacttgtg cgtttttttc cgtgcgtcag atggcataaa atgacgcatt 2592901 tccatttccc accgatcact tcaagagtcg cttcaacaga aatgttatat tttttcttct 2592961 ccatacaatc cattctcctc acaggcacca aaaagtgact atagcacttc aaagtacgta 2593021 cttttatttc ttaacgatat gtttcataat cacatttgcc ggctgatttg aatctgctct 2593081 tttttattta tatagcttac tcggcagaat ttcaatcata caacacatct tacaaaggag 2593141 gaacatcatg acttcagcca ataaaagcaa tattcctgca ctactggctt tggccgtaag 2593201 tgcattcgca atagggacaa ctgaatttat cagtgtcggc cttttgccgc tcattgctga 2593261 tgacctggat attcccgtca cgacagcagg attgaccgtt tccctttatg cgctcggcgt 2593321 tacatttggg gcacctatat taacttcatt gacctcaagc atgtcacgta agacactatt 2593381 gctttggatc atgtttattt ttattgccgg taatacgatg gcagcaaccg cttcaagcat 2593441 cgggatttta ctagcagcac gtgtgatatc ggcattttcg cacggtgtgt ttatgtcgat 2593501 cggttcgaca atcgcagcgg atattgtccc ggaggataaa agggctagcg cgatttcaat 2593561 tatgtttact ggcctcactg tggcaactgt aaccggagtt ccttttggga catttatcgg 2593621 ccagcagttc ggctggcgtt tcgcctttat ggtcattatc gccgtcggaa tcattgcttt 2593681 cattacaaat ggcattcttg taccgtccaa attacgaaaa gggacgaaaa caacgatgcg 2593741 ggatcaattg aagcttgtga caaacagccg gttattgctt ttatttgtca ttacagcgct 2593801 tggatacgga ggaacattcg ttgtgttcac gtatctgtct cccctgcttc aggaagtaac 2593861 aggcttcaaa gccgggactg ttgcagtgat tctgctcgga tacggaatag ctattgctat 2593921 cggcaatatg attggcggaa agctgtcaaa ccgaaatccg attgccgctt tattctatat 2593981 gtttatcgta caggcaatcg ttctattcgt actgacattt acagccccgt atcaagcagc 2594041 agggctcatt accattctct gtatgggatt gctggccttt atgaacgtgc ccggccttca 2594101 ggtgtatgtc gtcatgctgg ctgagcgttt tgtcccgagt gcagttgacg tcgcatccgc 2594161 gatgaatatc gctgccttta atgcagggat cgcgcttggg tcataccttg gcggtgtgat 2594221 caccgattca atcggattga ttcataccgc ttggataggc ggattaatgg tggtcggtgc 2594281 agtcatttta acaggctgga gccgcttgat ggaaaaacga gatcggcagg aagcctgaca 2594341 attttaaagg aggaaataaa catgacaaca catttacaag caaaagcaac acttcataat 2594401 ggggtagaaa tgccttggtt cggcctcggc gtgttccaag tggaagaagg atctgaactg 2594461 gtaaacgcag ttaaaactgc cattgttcac gggtaccgca gtattgatac tgcagcaatc 2594521 tatggaaatg aagctggagt cggagaaggg attcgggaag gcattgaaga agcaggcatt 2594581 tcaagagagg atctgtttat cacatcgaaa gtatggaatg cggatttagg ctacgaagaa 2594641 acactcgccg cgtttgaaac aagtctgtcc aaactcggtc tggattattt ggatctatac 2594701 ctcatccact ggcctgtaga aggaaagtat aaagaagctt ggagagcgct tgaaacgctg 2594761 tataaagaag gccgtatcaa agcgattggc gtaagcaact tccaaattca ccatcttgaa 2594821 gatctgatga cggcagctga aattaagcct atgattaacc aagtggaatt tcacccgcgc 2594881 ctcacacaaa aagagttgat aagatactgc caaaatcagg gcatccagat ggaggcttgg 2594941 tcacctttaa tgcagggaca gctgctggat caccctgtat tggctgacat cgctcaaaca 2595001 tataataaat ctgtcgcaca aattattttg cgctgggatc tgcagcatgg cattataacg 2595061 attcctaaat caacgaagga acaccgcatt aaagaaaatg caagcgtatt tgactttgaa 2595121 ttaacgcagg atgacatgaa ccgaatcgat gcactgaatg aaaacttgcg cgtcggtcct 2595181 gatccggaca actttgattt ttaatggcca aaaaacaccg ttcaatatga acggtgtttt 2595241 ttgtattatg cccagctgtt catgatttca tcaagctgcc ttttggtctc ttcaagcgtg 2595301 ccgctgttat caatgacttg atctgctctt gctgtttttt cctctaaggg catttgagag 2595361 cggatacggc tgactgcttc ttcttctgtc agctgattgc gcttcatcag acgttccagt 2595421 tgaagctctt ttgtcacact gaccacaata attttatcaa ccaatgattc caatttgctt 2595481 tcgaacaata gcgggatatc caatacaaca aatgcctccc gatttgcaac ggcttcatca 2595541 cggcgattga gcatttcctg cctgactgcg ggatgaacaa ttgcatttaa agcgagacgt 2595601 ttttgttcat ttgtaaatac cagcgctcca agcttttttc tatctatatc gccatttgag 2595661 agcagtatgt cttcaccgaa ttcgtcaatg atttgccggt aggccggcat ccctttttct 2595721 accgcttgtt ttgcaatgat atctgcatct ataactgtta ttcctttttc aatcagcata 2595781 ttggctaccg tgcttttgcc gctagctatt cctcccgtta aaccaatgac taaggtcaag 2595841 agatccactc ctttttacaa tttccagagc ccaatcgtga ttaatagaag ccccggcaaa 2595901 aacgccattt tatcgatcca tttccactta gacagaaaat ggccggcatt gattccaatt 2595961 gatacaaaca gcgagctcat gattgccacg gcgatgctca tcacaatcgg cgaaaaaccg 2596021 agaatggctg cgcctatacc tgctccaaag gcatcaatcg ataaggcaaa tcccaataag 2596081 accgcctcaa ttccgttgat cacacccgat ttgtcgatat ccgcactcat gggttttctc 2596141 aaaatatgaa tcacaattcc taatgaccga acctctagat taagcagtgt tttttcatgc 2596201 aataggtatt ctttatcttt tgccggtttg aaaaattgat acagaaccca cgcaccgatt 2596261 ccaaccaata tcaaaccgcc aagcttctcc gtcacatata caggaaaaaa cttcgtgaga 2596321 aagcttccga tcagcatgga tataaacatg acagcaccgg aacagcaggc gataaccaaa 2596381 atcgctttaa acggtatttt catttttctc aatccgtacg taaatccgac tgaaaaactg 2596441 tccaagctga cagccaacgc cagcagcagt atagaaacca tttgcatatc cgtttcttcc 2596501 tttctgttgg tgctcttgta tcagatgtga aatgcccggg attcatcaca atcatatata 2596561 tgggaaagtg aaaaatccgt gtttcgaaaa tggcatcctt aatccagagt tactgatata 2596621 tgcaccgaca gcttggacaa tgaagcatta tgctactttt ttgtctggca ctttgcgcaa 2596681 aaatgcgtgc ctcttcctcc aacgacaatt ttcgaaatca tcgttccgca atttttgcat 2596741 ggctcgtctt tttttccgta cacaaaatgc tgcagctgga acattccgat ttccccttgg 2596801 gagttgatat atgaacggac tgtgcttccg cccgcatcaa tcgcctcctg cagagtgttt 2596861 ttgatttcag cgtgaagggt tttgattgtt ttatctgata attgatttgc ttttgtctcg 2596921 ggatggacac ccgctctgaa aagagcctca tccacataaa tgttcccgag tccaactacc 2596981 gttttttgat ccagtagggc agttttgaca gcgcggtttg ttttcgcaag ccggtctttt 2597041 aaatacgcac ttgtaaattc ttctgcatcc ggctccggcc ctaactgaga aagcgggagc 2597101 tcgcccgctt cttctcccgg tttaaataag tgcatggttc caaatttccg cacatccctg 2597161 taccggagct gggttccatc cgtcatcgtg aatatgacat gcacgtgttt atcgtcaggc 2597221 tcctcggctt gatgaagacc gtattttcct tccattcgaa ggtgagaaac cataacataa 2597281 tgatctaaat gaaacagtaa aaactttccc cgtcttccga tggactgtat cgtttctcct 2597341 gctagttttc gcgcaaattc ctccggttcg gcaggccgtt tgatgatatt cggccatctg 2597401 atctctaccg atttgattgt ttttcccttt acaagcccgg tcagagtgcg ccggaccgtc 2597461 tcaacctctg gtaattccgg cacatccatc acttcctatc tctgtttatt tcgcatcgta 2597521 ccaagatggg cctgatgcaa agtccacctt taacggcaca tctaatgcaa gcgcatgctc 2597581 catcacttca ggaacaagct tttcaagaat ttcaatttct tcctttggcg cctcaaaaat 2597641 caattcatcg tgtacttgaa gcagaagcct tgctttcaac tgtttttctt tcagcttggc 2597701 agccatgtca atcatggctt ttttgataat atcagcggcg cttccttgaa tcggcgtatt 2597761 catggccgtc cgctccgcaa aacttcggat attaaagttc cggctcgtca gctcagggat 2597821 gtagcggcgg cgatgcataa gcgttgttac gtatcctttt tgtttcgctt cctgtactga 2597881 atcttccatg tacgctttta cgccttggaa gctttccaga tagcggtcga taaatgctcc 2597941 cgcttccttc cgggtaatgc cgaggttctg tgacagaccg taatcgctga tcccgtaaac 2598001 aatgccaaag ttgaccgctt tcgcctggcg tctcatcgca gatgtcactt catccttagc 2598061 gacatggaac acatccattg ccgttttcgt gtgaatatcc atatcattag taaaagcttc 2598121 gatcagattt tcatcctttg aaatatgggc aagcacccgc agctcgattt gtgaataatc 2598181 ggctgcaaaa atgagccagt ctttttcaga cggcacaaaa gcttggcgaa ttttccgccc 2598241 ttcctcaagc ctgatcggaa tgttttgcag gttcggatca gtcgagctga gacggccagt 2598301 ttgcgttaag gcctggttaa atcgcgtgtg cactttatgc gaatccggtc tcgtcacctt 2598361 taaaagccct tcgatatatg ttgattgaag cttgccaatt tgtctgtact gtaaaatata 2598421 gtcgacaata tcatgcttgt cagccagctt ttcaagcaca tcggcagacg tagaatagcc 2598481 tgttttcgtt ttctttacga caggaaggcc gatcttttca aataagatga cgcctagctg 2598541 tttcggagaa ttgatgttaa acggctctcc cgcaatctca tggatttttt cttcatattc 2598601 cttcagcttc gcacccagtt cttcacccat ccgttttaaa cggtcaacat cgaccttgac 2598661 gccagttgat tccatttcgc caagaataag cgcaagaggc atttccagct cttcaaacag 2598721 ttcaagctgg tcgttgtttt ccagctcttg aacgagcttt tcccgaaggc tttgaatcgc 2598781 taacgctttt cggccaaggt gctcagacag tacgtcttct gacggcactg cccgttttgc 2598841 tccttttcca taaactgatt catcacttga aacgatatgc aggccgtaat ccttagccac 2598901 actcgcaacg tcgtcatatg aattgcccgg gttgatgata taagccgcaa ggagcgtatc 2598961 aaactcggct cctttcagct caatgccctg ccagcgcaaa gcgacaacgg cccgcttgct 2599021 gtcgaagacc catttcttct gctcgtcatt ttccacccat tctttaaaca cctcagactc 2599081 aacggcaatg tctttcggaa tgaaataagc tcccgtttca tttacgatcg aaaatccgag 2599141 gatcggctct tcatgataat tatcgccaat ctgttcaacg acaaatgcgg atggagaaac 2599201 caatatatcg cttgtcacgt ctgtgactgt tttgacatta atgtcttcca acgattgatc 2599261 ctgttctgct tctgcactgt cttctccaag ccgttcaaga agcgtgttga agccaagatc 2599321 tttaaagatg gcaatgacct gttcacgatt aaagccttga tattccaggc cggaaacaga 2599381 tacctcaatc ggagcatccg tcataattgt cgcaagctcc ttgctcatca atgcctgatc 2599441 cttaaactcc tcaagctttt ccttcaattt ctttccgctc acctcgtcaa tggactccag 2599501 cagcttttca acggaatcaa attgttttaa aagcttaatc gcagtctttt ctccgacgcc 2599561 gggcacaccc ggaatattat ctgaggaatc gcccatcaga cccttcatgt caatgatttg 2599621 ttcaggcgta agcccatatt tctctttgac atgctccggt gtgtaaaatt caacatcggt 2599681 aattcccttt ctcgtaatgg caactgtcgt tttgtccgtt gccagctggg ttaaatcctt 2599741 atctcctgag aaaaccttaa cttcaaatcc gtctttttca gccgatttgg ccagtgtgcc 2599801 gataatatca tccgcttcat attgttccag ttcatagcgg ctgatctggt aggcatccag 2599861 cagctcgcgg ataaacggca tttgttcgga aagctcaggc ggggttttct gtctgccgcc 2599921 tttatattct ttaaatgtgc cgtgacgaaa tgttgttttc ccggcatcaa acgcaaccag 2599981 catgtgcgtc ggtttttcat cctcaagcat tttcatcaaa atcatcgcaa agccgtatac 2600041 agcattcgta tgaacacctt tatcattgct taacagcggc aatgcaaaaa acgcccggta 2600101 agccagactg tttccgtcta caagcactaa tttttttcgt tccgtcattc aatttcctcc 2600161 taagaagcct caggcttcca ttcatctctt acatagtcat tagctcctct tattttaaca 2600221 aagttcaatt tgaaaggaaa atacgtgaac tataagagaa gacacaaaaa aggacgggaa 2600281 cacaaatagg ttcccgccgt caaaattggc tccttggatg aaggggttct actacatcct 2600341 accagcatag gtttaacagt gcatgaagat attgttaaac ctttgtaaac attaggcgga 2600401 cttttcagcg gcccgtttca gcgtcacggt aaagacagtt ccccgtccaa gctcgcttgt 2600461 gacatcaatt ttcccttcat gagcctctat taaatgcttg acaatcgcta ggcccagccc 2600521 ggttccgccc gaatttctgc ttctgtcttt atctacacgg taaaagcgtt caaagatgcg 2600581 cggaatttct tctttctgaa ttccgattcc agaatcggca acctcaatct gaatgtcttt 2600641 ttctctgggc tttacattga tagccacgga gcccccctca ggcgtgtagg ttaatgcatt 2600701 gtttacgaga ttaagaaata cctgtttcag cctgtacggg tcaccagata catattgagg 2600761 gtctttcggg acattcaggt gcaaggagat gcctttctca tccgccttat gcttcagaag 2600821 cgtttcaatc tcaccaagca ttttggccgg ctcaaacgtt tcgatactga gcgtgaaatt 2600881 ttgctgctcg atttttgaga gatcgagcaa atcctgaacc aaagactgaa gcctttcgct 2600941 ttccttaaga ataatagaga gaaattcaga aagcgcctct ttgtcttcca tcgccccgtc 2601001 caataacgtc tccgtaaacc cttttatgga cgtaatcggt gttttcagct catgagaaac 2601061 attggccaca aaatccttcc tcatctgctc taatttcttc gtttccgtca tgtcatggaa 2601121 aacgagcaca attcctttcc attcatcgtc cggccccata atcggaacgc cgtccacttc 2601181 aaaataacgc cgttctattt tgatcggcag tcttaacagc ttgcatttct ttgtctccgt 2601241 cataaaaatg tcttcgacaa gctggatcac ttcttcatgt tcaaatgcat cgtgataaag 2601301 acggcgcagc atatgattcg gattgatatg aaactgcttg gcgtaagacc tgtttacgag 2601361 attaataaag cctcttccgt cgatcataat cagcccggag ccaatgtttt caatgactgt 2601421 cagcagccga tcccgctgca tttcctgcgt tcgcgtcatt tccatcagat caatggcaag 2601481 gctgttcatc gcatgtccta gcttatcaga acgcctaata tagccgccgt acgtccgtgc 2601541 atcgtagttg cccttagaga gttctgtggc tacatttgtc gctgactcaa ttgacctttt 2601601 ataacgtgag gtcatgctgg aataaaaata aacaatgacg ataaatgcgg tacaaagact 2601661 ggccgtcagc atcccccaca attcgccttt taagccgtcg cttttttcag aggcggaaag 2601721 cagcacatat cctgtttttt caccttcgct tctaagtgaa agtccgtaat aaagcttgtt 2601781 atctgttgtt gacagaatac cctcatggcc agaaacaagc gcctgcacct tttgggaatc 2601841 agccgatcta ccgtttgacc catacagcac cttaccgtct gtatcgataa cggatgcgct 2601901 cacatcaagc gcgccgcctg catctttaat gattttctca tttgcttgat tattcagatt 2601961 gccggcatca agaagcgaag ccaagtattt tgcttctttt tcaatgtgtt cctctgcttt 2602021 cctttgatca gatgtttcaa aaagctgctg taaaaacagc ccgaggacac aaaacaccag 2602081 aatcatacag acaacgaata cagaaaaaag gcgcacacgg tatttattca ttcatttttg 2602141 gctcctccag tttatacccc aatcccctaa tcgttttaat gtagatcggt tttttggtat 2602201 tgttttcaat tttgtcgcga agatggctga tgtgcacatc aacaattctc gtatctccgg 2602261 caaaatcata attccagact gcgctcagca gcaggtctct tgtcagaact ctgcctttat 2602321 gtctgcctaa atagagcagc agttcgaatt ctttcggtgt cagttcaagc tgactttctt 2602381 taaagtacgc ttcataatga tcaggcagga ttttcagatc gccgattacg atctggcctt 2602441 ccatttcatc gttcttcatc tcactagagg gcgcagctat ttccgaacgc cttaaaatcg 2602501 ctttgactct cgcatttact tcccttggac tgaacggctt ggtcatataa tcatcagcac 2602561 cgagctccag ccctaatact ttgtcgaatt cctcatcctt cgctgtcagc attaaaatgg 2602621 gaaacatcag tttttgctgt ctcagctgct tgcatacttc gattccgtcc aattttggaa 2602681 gcatcacatc aagcacaatc aaatcaggtt tctctgtttc cgcttttttg agtgcttctt 2602741 ccccatccga ggcggtaatg acatcatagc ctgaccgttc caaattgtac tgtaaaagag 2602801 taacaataga ttcttcatca tccacaacta aaattttctt gttcatgctg tgcctccagt 2602861 attataattc cccgacatcc tatttctcta ttttatgtca tcttaacatg tttcatgatt 2602921 ttattttagc gaaagcagga cattccgaca attcgccttt tacatcattt ttaaaagaaa 2602981 taaagacgtt tatgatagcg ctttcattta tagtaaaaag agaaaggctg tattaagcaa 2603041 gcctttctct ctttttatta ggataatact ttcatgacat ttttgacaga ttcaactgat 2603101 ttattcagct gcgctctttc atagtctgtc agttcaagtt caatgatttg ctcaagaccg 2603161 ttgccgccta caattgtagg aacaccaagg tagatgcctt catagccgta ttccccttca 2603221 agataagcaa ttgtaggaag gacgcggcgc tgatctttca agatcgcttc gaccatttct 2603281 gtcagagaag ccgcaggcgc ataatacgcg cttccgtttc caagaagatt cacgatttcg 2603341 cctccgcctt ttctagtgcg ctccacaatt gcgtcaatcc gttctttcgg aataagagtt 2603401 tcaagcggga taccgccagc ataagaataa cgcacaagcg gaaccatatc gtcaccgtgt 2603461 ccgccgagta cgaaaccagt cacatctttc actgacaggt ttaattcctc tgccacaaat 2603521 gttctgaatc ttgccgtatc aagcacacct gactggccga ttacacgctc tttagggaag 2603581 cctgattctt tgtacaccgc gtatgtcatt gcatcaacag gatttgtcag caccacaata 2603641 atagagtcag gagaatattt cacgatttcc tgcgtaacgc ttctcataat cttttcgttt 2603701 gtagagacca gatcatctct gctcatacca ggttttcttg cgataccggc tgtaatgaca 2603761 acaatgtcag agccggctgt atcctcgtaa ttggatgttc ccgtaatttt tgcgtcaaag 2603821 ccttgaaccg ggcttgcttc aagcatatca agcgcttttc cctttgtcgg gttctccaat 2603881 tgcggaatgt caacaagaac aacgtctgcc agctcttttt gagcgattaa aaatgcagtt 2603941 gtagctccgg taaaacctgc tccgataaca gaaacttttt tacgagtatt tcccatgtct 2604001 ctcttctcct ttatggctag ttttaggctt tttccttgct tagtccatgt ttttgatcag 2604061 ttcttctccg aactctgaac atttcacttc agtcgccccg tccattaatc tggcaaaatc 2604121 gtaagttacg actttagaag cgattgtttt ttccatagat ttgataacca aatcagccgc 2604181 ttcgttccat cctaaatgct caagaagcag aacgcctgaa agaataactg aagatgggtt 2604241 tactttatca aggcctgcat atttaggagc cgttccgtgc gtcgcctcga aaatcgcatg 2604301 tcctgtttcg tagttgatgt tcgctccagg agcaatgccg attccgccga cttgcgcagc 2604361 aagagcatca gaaatgtaat ctccgttcaa gttcattgtc gcaacgacat caaactcgtt 2604421 tggacgcgtt aagatctgct gaaggaaaat gtcagcaatg ctgtctttga taatgatttt 2604481 tcctgctgct tccgcttcgc tttgcgcttt gttggcagcg tcttttcctt gttcttcagc 2604541 aatgcggtca tattgagccc atgtgaagac tttatctccg tattcttttt cagcaagttc 2604601 atagccccag tttttgaagg cgccttctgt gaacttcatg atgtttcctt tgtgaacaag 2604661 tgttacagat ttgcggccat gctcgatcgc ataatcaatg gcagctctga ccaagcggct 2604721 tgttccttct tctgaaacag gcttaatgcc gatacctgat gtctcaggga aacggatttt 2604781 attgacgttt aactcatttt gaaggaagct gataagcttt tgcacttctt cagagccttt 2604841 tgcatactcg atgcctgcgt aaatatcttc tgtattttca cggaagatga ccatatcagt 2604901 atcttcaggg cgttttaccg gtgacggcac tccagtaaag tatcttacag gtcttaagca 2604961 gacgaatagg tcaagctctt gtctgagcgc tacgttcaaa gaacggatac cgccgccgac 2605021 aggtgtcgtt aacgggcctt taatcgcgat gaaatattcg cggatcacat ctaatgtttc 2605081 agcagggagc cactcacctg ttttattata agccttttct ccggcgtaaa cttctttcca 2605141 tgtaattttc ttttcgcctt tgtatgcttt ttctactgct gcttccaaaa ccttcgaagc 2605201 cgcgttccaa atatcaggac cggttccgtc tccttcgata aatgggataa tcgggttgtt 2605261 tggtacgttt aatactccgt tagagactgt aattttttca ccttgtgcca caataaaaac 2605321 ctcccagtat gtaattcata tttagaaaac attttatttt tcttatatag aaaataaaat 2605381 gatttttcct aacattcaat ttaaagtgta acccaatttt gatgtctgaa caagaggcta 2605441 acctcattga cgcaagccag cctccaatgg ttctttaggc tctttcttca atcggaacga 2605501 atttttgttt gtcagggcct gtgtaatctg cccgcgggcg gatcagacgg ttgttgtcat 2605561 actgctcaag aatatgagcg agccagccgg acattctgct tacagcaaaa atcggtgtaa 2605621 acaaatcatg gtcaataccg aggctgtgat atacagaagc cgaatagaaa tcaacgttag 2605681 gcggaagctt tttctctgat gtgacgatgt cttctatacg aatcgacatc tcataccatt 2605741 tgctttcgcc tgtcaggttg gtcaggcgct tgctcatttc tttcagatgc ttcgcgcgcg 2605801 gatcaccatg cttatacaca cggtggccga atcccatgat tttttctttc ttttcaagtt 2605861 tagcgcggat gtacggctca gcgttttcca cttcaccgat ttctgtcagc attttcataa 2605921 cgccttcatt cgctccgccg tgaagaggcc ctttcagcgc gccgattgct gcagtaatgc 2605981 ctgaatagat gtcagaaagt gttgcgacgc agaccctcgc tgtgaacgtt gacgcgttca 2606041 gctcatggtc agcatgtaaa atcaatgctt tgttgaaggc ttcaacttca attggtgaag 2606101 gctcttcacc gtttaatgtg taaagaaaat tctccgcaat accgtaatct tctctcggtt 2606161 caacaggctc aagacccttg cgaattctgg aaaacgctgc aaccaggcca ggcacctttg 2606221 cctgaaggcg gatcgccttt ctgtagttgg cttccgggtt catggtatca gcctcgctgt 2606281 caagcaggcc tagtaatgaa attgctgtcc gaagagcagc catgggatga acattttcga 2606341 gggaataaga tttgaagtgc tcaataattt cttgcggaac ggcagcttcc tttgcaagct 2606401 gctgctttaa ctcttcaagc tcttttttgt ttggcagcct tagatgccaa agcaagtaga 2606461 tgatttcttc aaaacttgca ttctctgtca aatcatcgat atcatacccc acatatgtaa 2606521 gggtatcatc aataatagaa ctaacagatg atgttgttgc tacaacccct tcaagaccgc 2606581 gtgtcgctgt catatataac atctcctttt caataaattt cccctttaag agtgttgtaa 2606641 aaacatgagg cttacttaaa aagcacgatg caagtatttc tctcccccaa aaagaaaatg 2606701 cttacatttt actggctgct ggaactaaaa ccctttgctt ttgaaagaac ataacaaatt 2606761 tttataagct tatttaagtt taagcctatt ctcattataa acaataatca gacatttgtt 2606821 aaatgtttac ctataatttt ttttttccat tctgtgattt ccccgaaaaa acgcctttat 2606881 ttgcgggttt ttgcataaaa aaaagcggct ttaaggccgc ttttttttat gaagtgaaca 2606941 gttttacgat ctgcatggct aaataagcaa tccccgctcc gatcagcggc cccaccgcaa 2607001 ctcctccaaa aagcgcgact gcaagaatgg tcccgatcac gagagcagtt gtaatatgcg 2607061 gatcattttc aagcagggtc aggccgtttt ttgcaatcag cgccactgcg atccccgctc 2607121 caagggcgat ccatgcgtag gaagaccgca ttgcttctcc aagctgctta aatccgattt 2607181 ctcccgtggc aatcgggaca agaacggcga tggtaataat ggtcacaccc cagttaatgc 2607241 cttttgactg gatggtcgga aataatttct gatcaagccc aacgattttg atgatcaaaa 2607301 ggacggatac agcaaagagc aatgattggt tttttgcgat aagtgcgata gccaagagta 2607361 aaattaaaaa taaattcgct tgtgtaaaca catgccatcc ctcctttaag atgaatgtat 2607421 tcatattcag ccgcagcgtg aatacatata aaaaatagga catgctgacg agaggaggac 2607481 cgtttttgtg aatcaatctt atatcactat ttttttcaga accctctttg tcatatcaat 2607541 gaccgcaggg tcgatagctg cggcctatta ttcgtttccg ttaacttatc cgttcctgat 2607601 cgcccttatt ctatcttcag tgattcatcc tgttgtcgat tatttggaca aagtgacagg 2607661 attcccccga acgataaatg ttctgggcgt tcttgctttt tttctgctcg cagccttcgg 2607721 cgtgctcacc attctggtag ccgaaatcgt aacgggaaca gcctatctag caaaaacgct 2607781 gcctccgcat atcagcacgt ttatttcata ttgcgaaaaa ttgtttacca ctcatattca 2607841 gccgctctat aacgagttaa ctcttttgtt tcaagaattg gaaacgaacc agcaggcttc 2607901 catcgtcact catatccaga cactcggtga ttctgccgct aaaaatgccg ggctcctgct 2607961 gtcccacatt ctagagatga tcccgagatt tttcgctctt cttcccaata cggcggcggt 2608021 tctgattttt tctcttctgg caaccttttt tatgacaaag gattggcata agctgaaagc 2608081 catgcttgtt ttaattctgc cggatcgtgt gacagctaac agcaaagcaa tcagcagcga 2608141 attaaaaaaa gcaatgactg gttttatcaa agcacaagcc gtcctcgttt tcatcacgat 2608201 ggtgattgta tttatcggcc tttctctctt aaaggttgaa cacgccgcaa caattgcttt 2608261 tttaatcggg cttgtagatc ttctccctta cttaggtgcc ggctccgtat ttgtgccctg 2608321 gattttgtat ttatcgatta cgggccagct gccccaagca atcggaattg gtatcctgta 2608381 cctcgtcgtt cttattcagc ggcagctgac agagcccaag atactaagta aatctatcgg 2608441 gatcgatccg ctggcaacac tcatcgccct gtttgccggc tttaaattat tcgggttttt 2608501 aggactgatt gcgggaccgg ctgtactcgt catcatccaa gctttcatca caacaggcgc 2608561 attaaaagaa atatggtcct atatcaccgt tcagcaaaaa taaaacggca gccgtttttt 2608621 catggctgcc gttttttatt tgatgatgat ccgcttattc ttcgacattc ctctcagcca 2608681 tttgaacaga atcggcttac accagccgcg ggtaaacggg ataagaagac aggcgccggc 2608741 caaatctgat aaaaagcccg gaagcatcag caatagaccg ccaatgaaaa tgcacagacc 2608801 gtcagcaatc gcttctcccg gcattttgcc atattgaaga tcacgctgaa ccttataata 2608861 cacttcggtt ccttgttttt ttgcagctgc tgcgccgata atgccagtca gaatcatgaa 2608921 tagaactgtc ggcaaaatac caatcagatt tcctaaaaat aggaatatac cgatttctat 2608981 tgccggaaac acaataaaaa gcaaaaacaa aaatctcata tccaagcccc ccacacgtgt 2609041 aacacgttct gttcaacaaa aggcatgata aagagaaaag gaagggattc cccttccatt 2609101 ttcacctgta attaaagaac gctcgcacgg ccttgataga ctgcgcctct ggaagcgtca 2609161 actgtaatat cctggccatc tgtcaaaata gatgtcgcat tttccagacc cacgataacc 2609221 gggatgccaa ggcttaatcc gactaccgca gcatggctag tcaaaccgcc ttcttctgta 2609281 ataagagcag acgctttttc aagggatgca atcatatcac ggtcagtgct tttggtaaca 2609341 agtaccgcac cgtcagtcat tttttgctca gcttcttttg cattttgtgc aacgacaacc 2609401 ggaccgtaag ctgatttgcg tccaatgcct tggcctttag cgatgatatc gccgacagta 2609461 tgaaccttca ttaagttcgt agtgccggac tcaccgacag tgccagctgt aataacgata 2609521 agatcgccgt gttttacaat tccgctgttc aatgattttt ggacagcatc ctcaagcatc 2609581 tcatctgttg agctcgcatt ttggccgctt tccgcgaata cgccagatac gagggcaagc 2609641 tttctggaaa tagagtcatt tacagtaacc gcaacaatcg gagcctgcgg acggtatttt 2609701 gcaatcatac gtgctgtatg gccgctttct gtcggcgtta cgatcgcagc agcattcagg 2609761 ttaatcgccg tatgtgcgac agattgtcca attgcgtctg taattgtcat gcccacttgg 2609821 tctctgcgtt ttgagagaat ttctttataa tttaatgctt cttcagaacg ggacgcgatg 2609881 ttatgcattg tttgaactgc ttcaaccggg taacttccgg cagcagtttc accagaaagc 2609941 atgatcgcat ctgttccgtc gaagatcgcg tttgcaacgt cacttgcttc cgcacgagtc 2610001 ggacgcgggt tgcgctgcat gctgtcaagc atttgtgtcg ctgtaataac aggtttgccc 2610061 agcgcgttgc attttttgat cagttctttt tgcacaagcg gcacttcttc agctggaatt 2610121 tccacaccta agtctccgcg tgcaaccatt aagccgtcag acacttcgag aatcgcatcg 2610181 atgttgtcaa cgccctcttg gttttcgatt ttagggatga tttgaatatc ctgagcgttg 2610241 tgctcttcaa gaagctcacg gatttcgagc acatccgtag aacgtcgaat gaaagatggt 2610301 gcgatgaagt ctactccttg ctcaataccg aaaacgatgt ctcgcgcatc cttttcagta 2610361 atccccggaa gattgacact tacgcccggt acgttaacac cttttttatt tttgagtgtt 2610421 ccgttgttta atacttttgt tttgatttcg cgtttagcgg catctacatc aagtacctca 2610481 agaccgataa ggccgtcatc taacagaatc gttgaacctt gttcaacgtc atggactaaa 2610541 ccttcatatg tcactgaaat tttatctgtt gttcctacaa cctcgtccat tgaaataatg 2610601 agctctttgc ctgtttcaag ctcaataccg ccgttttcca ttgtatgtgt gcggatttca 2610661 ggaccttttg tatcaagcag aattccaacg ttcttgccaa gttttttact tgcttcgcgg 2610721 atatttttaa ttcttgcacc gtgctcctca aaatctccgt gagaaaagtt taatcgagcc 2610781 acgttcattc ctgactccat taatttcgta agcatttcaa tactttcact tgccggaccg 2610841 atggtacaaa caattttagt ttttctcatt tggttcactt ccttctgaaa tcttcagcct 2610901 tcagctgtac attagataga cagttctttt gaaagctgat acatgttttg ctcaactgtg 2610961 tgttttgtct caagtatttc tataatatca tggtctacaa gcttattgtt ttgtatacct 2611021 acacagcgtc cgccttttcc ttcaagcagc agttcaactg catatgcgcc gagacggctt 2611081 gccaacacac ggtcagcagc actcggagaa cctccgcgct ggatatggcc caatacagat 2611141 accctagttt caagatttgt ttcttcttca atgcgtttcc cgaattcaac accgctgcct 2611201 acaccttcgg caacaataat aatactgtgc ttcttgccgc gttcgtggcc gcgttttaag 2611261 cgggcaatga tttcgtgcat gtcatagtct gcctcaggga ttaagatcga ttctgcgccc 2611321 cctgcaagac cggcccacaa tgcgatatcg ccggcatgac ggcccattac ttcgattaca 2611381 tatgtacgtt catgagaagt cgctgtatcg cgaatcttat caattgcgtc aattactgta 2611441 tttaaagctg tatcgaaacc gattgtaaaa tcagtgcccg gaatgtcatt atcaattgta 2611501 cccggtacac ctacacatgg aaacccgtgt tccgttaatt ttttcgcacc catataggaa 2611561 ccgtctccac cgataacaac aaggccttca ataccaagct tcttcaagtt tgctatccct 2611621 ttttcacggc cttcaactgt tttgaattca ggacatctcg ccgtataaag cttagtccct 2611681 ccacgatgta taatatcgcc tactgatccg agttcaagct tttcaatctt tccgctgatc 2611741 aatcccgcgt atccgttgta aataccgtaa acttcaacgt catgatagat cgcttttctg 2611801 actactgcgc gaactgctgc gttcattccc ggggaatccc cgccgctcgt taatacccct 2611861 attcgtttca ttctccattc acctcagcaa catatatgat taaacataac atgatcattg 2611921 ccctaaaaac aatgaaaagg gatctccatc ctccctatga aaccttacct attatacaat 2611981 taaataaatt gtttttaaat aaaatttaag gaatgtcaca aaaaataaac gtgagccaaa 2612041 ggcttcacgt ttatttagtt taccccgata tattgatctt caaccgagac tttgccaatt 2612101 gctttatatt tttcataacg ctgctgaact aattcttctt cgctcagctt cagtaaagtt 2612161 tttaacgatt gtttaagggt ttcgtccata tagcttgcct gcagcttcac atcatggtgc 2612221 gctccgcctt ttacttcttt aatcatatga tctataatac ctaattcttt taaatccggc 2612281 gcagtgattt tcattgtttc tgctgctttt ttagcaagac tggagtcctt ccataaaagt 2612341 gccgcggcac cttccggaga aataacagaa taagtagagt tttccagcat atgcaagtga 2612401 ttgcctacac ccagaccaag ggctccgccg cttccgcctt caccaatgac gatgcagata 2612461 acaggcactc gaaggccggc catctcaaac aggtttttgg caatagcttc actttgtcct 2612521 ctttcttcag ctgctcgtcc agggtatgcc cccttcgtat caataaaaca gataattggt 2612581 ctgttaaatt tgtcagcctg tttcatcaga cgaagcgctt ttctgtagcc ttctggatgc 2612641 ggcatcccaa aattgcggac taggttttcc ttcgtgtctt tgccgcgctg atgcccgatt 2612701 accgttacag ggaggccgtg gaacttcgca atcccgccga caatggcttc atcgtccccg 2612761 tacgctctgt ctccgtgaca ttcaaaaaag tcggtaaaca ggtgttcgat ataatcaaga 2612821 gttgtcggac ggtccgccag acgcgcgatt tgaacccggt cccacggctt caaatttttg 2612881 taaatatcat cctgaagctt agcgagacgg tcttcgagcc gttcgatttc cgcacttaga 2612941 tccatatcgg aatcttgggt gaattttttt agttcggcga ttttggtttg cagttcaatc 2613001 accggttttt caaattctaa tcttggagcc actcaatgtc acctcctgtt tgatgcatat 2613061 ccagcagatt ttctaacgtt tttttcatat cgtcgcgatg aataaccgca tcaagctgtc 2613121 catgttttaa taaaaactca gccgtttgga agtcctcagg cagtttttct cctattgtct 2613181 gttcaataat ccgtcttccg gcaaaaccga tcagcgcgcc aggctcagcg aaattgtaat 2613241 cgccaaggga tgcaaagctt gctgatacgc ccccggtagt cggatgcgtc attactgaaa 2613301 taataagacc ctgttcttca ctgaacagtt ttaacgcaga gcttgtcttt gccatctgca 2613361 tcaaacttaa tacgccttcc tgcattctag caccgcctga agccgtaaaa ataataaacg 2613421 gaactttatc agcttttgct ttttcaatcg caagcgtgat tttttcaccg acgactgaac 2613481 ccatgctgcc cattctgaat gaagagtcca tgacggcgac aacagccggg tgtccgccga 2613541 tggtgccctt gcctgtcaca acagcctcgt ttaaggatgt tttctcgcga tctttttcaa 2613601 gcttttccag atatcccggg aaaccaagcg gattttccga gagcattccc tgattaaatt 2613661 cctcaaagga ttgttcatcc atcaagcttt cgatacgctg ttttgcgttc attgggaaat 2613721 gataatcgca gttcatgcat acccgcatat ttttatccaa ctctttagtg agcatgattt 2613781 ttttacactt aggacatttt gtcataatgc cttccggaac atcgtgcttc gcttgatcag 2613841 acggtacgga agcatacttt ttctttttcg tgaatatatc ctttaacaaa tgattacctc 2613901 ccttttgtga agggttctct tcaccgcatg tcatcaaaca gatagacttg ctaataactt 2613961 taccgaaact attgtacttt ttttgtcaaa cgctgtcatc ctcaattcga caacttttta 2614021 ttcgatgacg tgctcggaaa ggcttgtatg aaatcagata aggtgttgaa acgacaaggt 2614081 tgacagcgca ttcaaaaata atgttaaacc cggctgaaat ttttttaagg ctaaccccct 2614141 aaaaaaattt cagccgtcag tttaacttga gaacagcgcg ccggtctccg ccaacgcgct 2614201 gccatttttg gaatgaatta aaattattca ccaataatcg taagttttct tgttttttct 2614261 gcgacttcct cagggtcaac agtgattctt gcaacacctg tttccatcgc agcttttgcc 2614321 acagccttcg caacagcagg cgcaacacgt ttatcaaacg gtgcagggat gacatagtct 2614381 gcgctaagct catcttctga aaccagtgaa gcaatggctt caaccgctgc gattttcatt 2614441 tcctcgttaa tatgagtggc acgcacatca agcgctccgc ggaaaatacc agggaatgca 2614501 agaacattgt ttacttggtt cgggaagtca gaacggccag ttccgacaac gcttgctccg 2614561 gcttcacgcg catcttccgg catgatttcc ggatttggat ttgccattgc aaagataatc 2614621 ggatcttttg ccatgctttg aaccatttct tttgttaacg cgcctgctac agagacaccg 2614681 ataaatacgt cagcatcaac gataacatct ttcagagaac cgtctttgcg atcttggttc 2614741 gtgaacttcg ccacttcatt tttgacatcg ttcatgccgt tcgggcgccc ttcataaatg 2614801 gcccctttgg aatcgcacat cacaatgtcg cgaacgccat aatgatgaag aagcttgata 2614861 atcgcaatgc cagccgcacc cgcgccgttt gcgacaactt taatggatga catggatttt 2614921 ccagacagtt tcagcgcgtt cacaagacct gctacggtta caatggcagt accgtgctga 2614981 tcatcatgga aaaccgggat gtttgtttct tttttgaggc gctcttcaat gataaagcag 2615041 tttggcgctg caatatcttc aaggttgacg ccgccaaatg tcggttccag caattttaca 2615101 gtttcaacga ttttatcaac atcgtttgtg tttaaagcaa tcgggaacgc atctacgccc 2615161 gcaaagcttt tgaaaagaac tgctttccct tccataacag gaagcgccgc ttcagggccg 2615221 atgtttccaa ggccaagcac agctgtaccg tcagttacaa ctgctaccat gttccccttc 2615281 attgtataat catatacttt gttaatgtct tcatgaatat ccttacacgg ttctgcaaca 2615341 cccggagaat acgcgaggct taaatctttc gcatttctga cctctacttt tgatttagac 2615401 tccagtttcc cctggttgac tttatgcagg tgtaatgctt cttctcttaa tgacattctc 2615461 ctaaacactc cttatggata ttttttgatt cgtatactgc tgcgttgatt gctgcattct 2615521 gcggagtaaa tctatctgaa tatttaaaca ggatcacata attgctccaa ttgtataaca 2615581 aaaagcgaat cgttaccact gttttaaaac gacgtttttt tgacccaaca gctcttttaa 2615641 gcgatataac acctggtgat ctgcattgat atggaacgac tcaggtagct taatcgtctg 2615701 tttttgcctt tcataataga gataaacgcc tgtttcccct ttatgctcca gcaaaatgcg 2615761 cttaatcttt gccaggatct cctggctgtg ctgactgctt tctattttta tataaaccga 2615821 tggcgctttt tctgcatcca tatcttctaa taattctgcc cgggacatga tgaattggat 2615881 cttatcttgt ctaacttcac atttccccgc agtgaacaaa agagcgcctt ctcttaaaac 2615941 gggagaaagc tgtctgaatt gttcagggaa gactacggct tccatctcgc cggtttcatc 2616001 actgagcgtt aaaaacgcca tgttttgacc tgttttcgtc cgaatcgttt tgatcttcga 2616061 cagcagaacg cctagtgaaa gctgcctttt gactgcccgc tgagcctgca gaatggagac 2616121 tgctccttgc gcagtgagct gttttcggaa ggcggagagg ggatgatttg aaaaataaat 2616181 gccaagcgtt tccttttcaa acgcaagtaa atccaccaga ggaagctcct ccgtctccac 2616241 atacttcggc ttaattgaaa acgattcatc taaaaacaat cccatttggt catcgtccgc 2616301 ggcgaatagc tcagcatgtt ccaaagcaac atcaatggat gcgagcagcg tggcccggtt 2616361 ttggccgaat tcgtccatcg caccagaaaa gataagtgct tcaagcattt tgcgatttac 2616421 gctttttgac ggcacgcgaa agcagaaatc gaaaagatct tcaaatggtt tctcttttct 2616481 tgctttatat atatctttga ctgctgagac gcctacactt tttatcgcgc ggaggctgta 2616541 tctgacagat ccgttttcaa ctgtaaacgg aaaactgctt ttattcactg acggaggaag 2616601 gatacgaatc ccgctcccct ttgcttcgta aagatattga gagattttat cctcattgcc 2616661 aatgacgctt gtcagcaatc cgcacataaa atataacgga taatgagctt tcaaatacgc 2616721 aagctggcac ccgatcatgc tgtatgccac cgcatggctt ctgttaaagc catagtttgc 2616781 gaatttgacg attaaatcgt agacctcatt tgcagtgtct acagaatact ccttttttaa 2616841 gcacccttca acaaaatggc ttcgctctct gtccaggatt tcttttttct ttttgctgac 2616901 cgcccttctc aataggtccg cttcgcctaa agaaaacccc gccatacggg aagcaatcat 2616961 cataatttgt tcctgataca caatgacgcc atatgtatct tccaaaatgc tccttaaatc 2617021 ttcatgagga tagtgaacag gcgcccgacc gtgtttacgg tcgataaata acggaatatt 2617081 ttccatcgga cccggccggt acagtgcatt gaccgccaca atatcttcta ggcccgaagg 2617141 tttcagccgt ttcaagacgc ttctcatccc tgcagattca agctggaaaa tgcctgtcgt 2617201 atcccctttt gacagcaagg agaacgtttt gtcatcgctg taggaaatac ttgaaaggtc 2617261 tattttaata ttttcttctt tttcaatcat tgaagtgatg gattcaataa gtgtcagatt 2617321 cctcaaacct aagaaatcca tttttaaaag gcccaagtct tcaagatggt ccatcgcgta 2617381 ttgcgttaaa tagatccctt catgcccttc ttgaagcgga acaacatctg ttaacggttc 2617441 ttcactcagg acaacgcccg ctgcgtgggt tgatgcatgc cttggcagcc cttctatttt 2617501 ccgggcaatt gaatagactt gctgaagcag gcttgactcc cgaagccgct tatccagctg 2617561 cggtgactgc tgtctcgctt catccagcgt cattcccggt cttgaaggaa tgagttttgc 2617621 aagctgatct gcctccttcg ggctgacgcc gaatactctg ccgacgtccc ggagcgccgc 2617681 ctttgccgca agtgttccaa aggtgataat ctgtgcgacg tgcattgcac cgtatttctg 2617741 ctgaacatat tgaatgactt catcccttct agtatcggga aagtcaatat caatatccgg 2617801 catgctgacg cgttcgggat ttaaaaatct ttcaaacaga aggtgatgct taatcgggtc 2617861 aacatctgtg atatacagca catatgccac aagagaaccc gccgcagaac cccttcccgg 2617921 tcctgtaaca atcccttttt catgggcgtg cttcataaaa tcccacacga tcagaaagta 2617981 atcgctgaac ttcatccgct tgatgacatc aagctcatat tgaagacggc gaaggtatcg 2618041 ttcatcaggc ttgccgaaac ggctgcggag tccctccata cagatatccg ttaaataatc 2618101 atcagcggac gttccgtctg gggtcggaaa agacggtaga cgggtctgcc cgagactgac 2618161 gtcaacccgg cattgttccg cgatctctac agaagcttgc agtgcctcgg gatgctctcg 2618221 ataaatgttt tgcatttctt cgagtggttt caaatcgaga tcaggcaaat cttcagcggg 2618281 tgcatccgtc agtttttccc ccgctttaat cgctttcaaa caacggtagg cagccttatc 2618341 ttccttcctt atgtaatgca catcgcctgt ggccgtaaca gggatacccg tttcttctga 2618401 cagctttaga atctgctcag acaagacttg attcccttta aaaggctgat aggagaaata 2618461 aaaagctccc tttccgaata tagactgaaa ttccagcgag gcttgagcag cctgttcgaa 2618521 cagccctcct tcaagaagcg tttcaatata tcctttttcg ccgggcgtta ttgcgataat 2618581 cccttctcga taactgtgaa gccatttcgg cttcagtccg ccttttgatt tagattgcag 2618641 aacgctgctg attttcagca ggttttgata gcctgtattc gattttgcca gcaggacgag 2618701 cgggtatgct tcaagctcgc tgtcatctgt aaaaacagaa gccgtcaaac cgattattgg 2618761 gttgatccct ctcgccttgc aagctttata aaattgaata gctccgtaca tgacatgatc 2618821 atctgtcagc gccaaagacg catatccgag cctgtcagct tcactgacga gttcttccac 2618881 agccgcggcg ctgtttagca ggctataccc gctatgcact tgcaggtgaa caaaagacat 2618941 gctatcacct ctttctcatt acgatccatt tcttccttca ttataaggcc ggtttccaaa 2619001 agaaacaaat gttctttttt gactcatcat catacttgtc ctgaaagctc aatatgatat 2619061 aaaaggtgag gtgataaaga tggatcagga agcaggattt atggtgaatt ttatcaatag 2619121 ctacttcatt gcgttagggg tgctgatcgg gggcgcactc atcggagggc tcggagcata 2619181 cttggcaggc gaacccccgc ttacagccat tacaaagctt gccaaccggt taaaaatatg 2619241 ggcgcttgtc gcagctatcg gaggcacctt tgatgcggta tacagctttg aacgcggcat 2619301 actcgaaggc aatacgagag atatctttaa acagcttctt ttaattattt cggccatggg 2619361 gggcgcgcaa agcggctggc ttattatatc atggctgacc caggagcatc tttcttcatg 2619421 agggtccccc agcattacaa aaaaccggga tggcagcgtt ttttcgcggg aatgatgtgc 2619481 ggagccgtaa tcagctggtt ctttttcctg tttacttacg gaacattcca agaggagcag 2619541 gtcagcctca tcgaaaagca aaaagagcat gtaaaagact tgaacaatca aatttcgatc 2619601 tatcaggaag acctccataa actgaatgaa gataataaaa gaaaactgct gattcaaagc 2619661 gtcagcgtca aattgctgaa tggggataaa tataaaatat cacagccgga taaaacgaaa 2619721 ttcgaggagc atgtaaagga tgatatttca gaggtgatta caaaagacat agagagcgtc 2619781 tatcaaacaa aggatctctt gaagcggaca attgaaaata aagtctatat gatcaatgaa 2619841 aaaaaatacg aggcaaccgt cagagaattg attatttata cgaggctgac agtggaactt 2619901 gaaatttctt tcgccacata attatggatt ttttttaaat tctccaaact tctgtcgctt 2619961 tttcccattc ttttttataa actatatgtg aggcttaatg gcgaaaggaa ggaggaaggg 2620021 aaatggaggt ttacagtgac cgtcagttag caaaagatca agcagcccgt ctcagacaag 2620081 gtttttctgc atatgccgaa acaaactcac tcgcttccct catcaaaaaa gaacttcaat 2620141 cacacaatct ccaagtctac gaggacctta ctgatttcgg ctgctggttc atccccgtca 2620201 cagatgaaca ctaagagaga gggtctcccc tctactcgtg ttctttacat aatgtttcca 2620261 gatcagctaa aatacgatca gcttcatccc agctgtaaat agaggcgcct gaagctaacg 2620321 gatgccctcc gccgttatat ttccgggcaa gtccgttaat gacaggcccc ttcgaacgga 2620381 atctgactct gatttgatcg tcttcttcta cgaaaaacac ccaggcgcga atacctgaga 2620441 tattgccaag cgtcccgaca agctgcgacg cttcagaagc cgttgtgccg aatttttcaa 2620501 gcgtatcctt tttgatgaaa acagaagccg ccccgttttc ggacaaagac acattttgaa 2620561 agataaagcc gttaagcttc accacattca gttttgtttc atacaattga ttaaataact 2620621 ctgaggaaga gaatggatac tgaatgagct cgcctgcata ttttagtgtt ttttccgtgg 2620681 tattcggaaa taaaaagcgt ccggtatctc caacaatgcc ggcgtagatc agctctgccg 2620741 ctttcgtatt cagcttccag ccgtgctctt ttccttctaa atacagctcg taaatcattt 2620801 cacttactga gctggcgctt gtatcgaccc agagaaggtc accgtatgga tcttcgttcg 2620861 gatggtggtc gattttcatt agtttggcgc ctgaaggata acgctgatcg tcgattcttt 2620921 cctgatttgc cgtatcgcag acaatgacaa gtgcgccttc atatgtttca ttgtccacct 2620981 catcaaggga atataagaaa gagagggacg gttcaggcgt gccgaccgca aaaatatttt 2621041 tttcaggata tgtttcacgc aggatttccg taagcccaca ctgtgatccg taggcatccg 2621101 gatcaggacg cacatgtcta tgtaagataa tcgtgtcata taatgatatg gttctgatca 2621161 attctgtttt catttgatac tcctttattg tttttattca ttaaatcaca ttctctgccg 2621221 acggaaaaga aaaataacgt caaaaccaag cccgtttttg tataaaatgg ggttgtaaac 2621281 ttttacgatg gaggatttca tttatgctgg ttcttgtttt tttgattggg ctttcagcct 2621341 gcttttatgt gtactataaa gtaaaaggcg tacgggcaaa gccatctttg gcaaaagaaa 2621401 tatgttcagc aaaatcaagc atggccttag ggtcactagt cctgttctac gggcttaacc 2621461 aaatgatatt attccattca gtattaacgt tagtaatcgg cggtatcttt atcgtcatag 2621521 gagcaggaag cgcttgggca ggttataaag ccttcaggca ttacaatccc cttcacgcca 2621581 aagaagctga aagagatcac gcgtaagggg cgcctgaacg tcccttagct tctttccatc 2621641 agctgaacca tcagcatcgc tttagacacg atatgacctt ggctgtgcac ttccacttcc 2621701 attttcccaa actttctgcc ggcctccaag atgcgaggtt tgacttcgat gactgattcc 2621761 atctgcacag gcttcaaaaa gaagatggtg atgctctcta tgacgagttc gccgcgtttt 2621821 ttcgagcgca aaaatcggtt tgccgcttgc gtcaaaatgg tcgtaaatac gccataagaa 2621881 atggttccaa gctgatttgt catttgcggc gtgacttcat actcgtaaac cgtttgatct 2621941 tctttatcat caccctcatc tttaaacccc cttgaaacga tatcatcaag cttctccccg 2622001 acctgcggct gcttttgaat catttgaaga gctttcaata cgtcttggcg gctgatcatg 2622061 ccgatgagtt tttggtggcc gtcagtgacg ggaagcactt cgatcccttc ccataccatc 2622121 atttgcgcag ctgaagcgac agatgttttc ccaataaccg tgacgggatt tttggtcatg 2622181 actttttcta tagatgcatt tcggtcatgg ccagcaatat cttttgatgt cagaatgcca 2622241 tggattttca tttgatcgtc gacaaccggg aagcggccgt gccccgtttc aaaatttttc 2622301 tcataccatt tttcaagttt atccttaggc gaaagatata ccgtgcggtc agcaggtgtt 2622361 aggatgtcct ccaccaaaac aatttctttt ttgatcagct ggtcatatat tgcccggtta 2622421 atcatcgcgg caactgtaaa ggtgtcatag ctcgtggata aaatcggcag ttcaagctca 2622481 tctgccagct gcacaatgct gtcatccgtg ttaaagcccc cggtcaccaa tacggccgcg 2622541 cccgcttcaa gcgcctgcct gtgtgcattg attctgtttc cgacaatcaa aagattcccc 2622601 gctgcggtgt aacgcatcat cgcgtcaagc tccatcgcgc cgatgacgaa tttattcaat 2622661 gtcttatgga gccctgccct gcctccgagc acttgtccgt ctataacatt tacaacctct 2622721 gcataggtaa gcttttcaat gttctctttt ttcttttgtt caattctgat tgtgcccaca 2622781 cgttcaatcg tgctgacaaa ccctttattc tctgcttcct tgatcgctct gtacgcggtt 2622841 ccttcgctta ctttcatttc ctttgcaatt cttcggacag aaattttttc accgacaggc 2622901 agtgaatcga tatacgttaa aatttgttca tgcttcgttg ccaagccttt cacctctaag 2622961 gacagtcttc ttgtttttat tataaggttt caaaggattt atacgcaatg aggctggaaa 2623021 ataaaaaaga agcccgaccg gcttcttaca gcgttgattt cgttccagtc aaacgcaagg 2623081 accacgtgat tccttttaca tcgtaaagcg gaaaaacctt tatttttctt ttaaatggac 2623141 atcaaccgct gtcttaacaa tatttcgatt ccctatttta gataaaacaa ataaaactgc 2623201 ggatagccat atcgccccta tggccgtata gatcaatgga tgaacagctg tgtttgcgat 2623261 ccattcattt attaatgttc tggcatttac cagaataata aatcctccta caagcacacc 2623321 catcaattgc ggatgaaact tctgcaccag ccatgctgcg ataggggcag cgataattcc 2623381 gccggccatt agtgaaaaca cccataacca attgacgtcc tcccatccta atgaaataag 2623441 aaaaccggcg gttgcagata cggcgatggc aaattcactt gtgtctacag tcccgacaac 2623501 tttcctcggg ctcaagcctt tgcgggataa taaaatcgga gtggtcaccg gtccccagcc 2623561 gcctccgcct gtggcatctg caaaaccagc gatcactccc aatgggatgg attgttttcg 2623621 gtttaacggc acatgcttct tctcaagagc cggcttatat tgaaataaaa acctgatcaa 2623681 tacatatccg cccagaagga gcaaaaacaa agaaatatag ggtttcgcca catctccagg 2623741 taattggctg aggaatgccg cgcctaaaaa agcgcctata gagccgggaa tgacaagctg 2623801 ataaacggtt tgtttgtcaa cattgccaaa tttaatatgc gacactcccg atgcggcagt 2623861 cgttacgact tccgctaaat ggacagaagc cgaagccaca gcaggtgtga tgccaaacgc 2623921 caataacaaa gaagttgagg taaccccata agccatacct aacgaaccgt ctattaactg 2623981 cgacaataaa ccaataaatg caaaaacgat taatttcttc atcagaacac cccatctata 2624041 tcaatcagat atttttgact cttcattcga atctaacaat ctcttggcgc tttcatataa 2624101 aaaataagag gctttgataa ttgcagtttc atctattgta aatgcagggt ggtgccaatc 2624161 atgatcaccg tctgttccaa aaaacgcaaa ggatcccgga atatgctcaa gataataagc 2624221 aaaatcttcc cccgcggttg atggggcggg atcaatgact tgaagtttcg ctttatgtgc 2624281 agcgtctcgc accagccccg taattgcctc atcattacaa agcggcggcg gtccggaatg 2624341 ccacttcaca tttgccttta acgagaaagc ggcagaaatc tgctctgtga ctgcaaaaaa 2624401 acgctgtttc acttgattac gaacctctga atcaaatgta cgaacagtgc cctcaatgac 2624461 cactgtatcc ggaatgacat tccaagtgct gccgccgttg attttcccta cggttaaaat 2624521 cgcgctttgc agcgggttta catttctgct tacaatcgtt tgcagggcga caataagctg 2624581 agaggcgccg ataattggat caaaaccatt atgcggcaat gctgcatgag cacctttccc 2624641 ttctatctct actttaaatc ggtcaacagc agccataagc gggcctgttt ttaaccctac 2624701 agtcccaacc gcgatatccg gtttattgtg aaggccaata accgcatcaa tgccatccag 2624761 ttggccgtcc tctatcactt ttgtagcgcc tgcacccgct tcctctgctg gctgaaataa 2624821 taaacgaatc tttcctttca gactgtcttg attttccttc aataaaaagg ccgcaccaag 2624881 aagcgctgcc gtatgaaaat catgaccgca cgcatgcatg atccctttat gtttagacgc 2624941 ataaggcaat cctgtttttt cttcaattgg caaggcgtca atatcagccc tcaaagcaat 2625001 cgccggacct tctgactccc ctgctatgtc tgcgaacaca cccgttttta gagcagtagg 2625061 gcgaatctgt atcccctttt ctttaaggca tttttttata aaagcagttg tttcaaattc 2625121 ttcttttgac agttcaggat attggtgcag gtgccggcga atgccgatga gctgcttttc 2625181 tagcgttgag agatttacgg gattagactc ctctttcaac gtcaggatgt catttcctgt 2625241 agtctgatat ggataggagc cttctatatt tctccaataa tccaaagaca tatgttccgc 2625301 tcctttccct atcccaatat attttcttca gactcttcaa cataagatga aataaatcgg 2625361 ttcaatttat cagcaagacc gcccgcccca aatcttatat acttgctgga aactttcgga 2625421 ttatcttctt tcaaaaagct taaaaaagat aaaatataaa tgcgcctgta agctacttgt 2625481 gtaattccgt actcaaaaaa ccagttatca atgacattgt atacgcctcg gttgacgcca 2625541 tataggttat tacatttctt gtaaaagcag agatccggaa gatttaactc ctgatgggaa 2625601 agaaggcttt cttttttgtt tggtgccata atcccaatca gctcaaagcg ttttgcaacg 2625661 cacgaaatat cctttttaat ttgctttgtt aaagactcca aagaatcaaa ccttctttct 2625721 tctctaattt taaagagaat gctgcattcg attttttctc cataaatgtc tctatgaaag 2625781 tcaaacaaaa aaatctccaa tgtcttttca aggttagagc ccaccgtcgg tttcacaccg 2625841 atattcataa cccctaaatg aaattgatga ttgactgtcg ccagaacccc ataaactcca 2625901 ttacgcagcc catgtatttt tgcatctaca tttgccgtgg ggaatccaag ctttctgcct 2625961 aattgttttc ctttcacaac cgtaccggca atgatcgtca aaaaagtcag cctcctctct 2626021 cagcttccgc attcgatcag acgaaaccta atgatgtgat gaatgtaaaa cggattgatg 2626081 ctgcggaatg ccaagaccga gattttcccg caatgtcccg ccgcgataat cttgacgata 2626141 aagccctctt tcttgaagaa tcggaatcac cttttctaca aaagcatcaa gtgttcccgg 2626201 tatatccgac ccaacgataa acccatccgc cgcctcagcg ttgaaccaag tttcaattaa 2626261 ggatgcgaca cgctctggtg ttccgatgaa tagagtccgt ggaaaagcca tttcctgtgc 2626321 tacctcccgc aatgtcagat ttctggcttt tgcttctctc ttaatccggt ctgttgtgct 2626381 ttgaaacgca ttctttccca catcgccaat atcgggaaat ggctcatcca acgggtaaac 2626441 actcagatca taatcatcaa aaaaacgggc caaataagta acagcatttt caatcggtat 2626501 caattctgca aattcacgat acttcttttc cgcctcttct tccgtatctg ccacaatcgg 2626561 gctgatccct ggaaaaatcc gcacacttga aggatcacgc ccttcatcag cagctcggct 2626621 tttcacatcc gcataaaacg cttttgtctc ttctaatgaa ttggaatggg taaaaatcgc 2626681 atccgcattt ttagcagcaa actgccggcc tgtttctgat gaacccgctt gaaacactac 2626741 aggctctccc tgcttagagc gcccgatatt caagggcccc tctacttgaa aatactttcc 2626801 tttatgattc aggcgatgaa gcttcgcctg atcgaaaaac tgccctgttt tcttattgtg 2626861 tataaatgcg tcatgctccc aggaattcca cagcccgcgc acaacatcca aatgctcttg 2626921 tgcgatctcg taacgttcag tgtgttctgg caaattagac ttactatggt tgcgcgccgc 2626981 tccttcctgc ggcgaagtaa ccagattcca gccggccctg cccccgctga tatggtccag 2627041 cgacatcaat tgtctggaga tagtgaatgg ctcagtaaaa gatgtagaga acgtccctac 2627101 taaaccaata tttttggtaa ccgatgccag cgcagataaa atggtgatcg gttcaaaacg 2627161 gtttaaaaaa tgaggaatcg atttttcaga aataaataag ccgtctgcaa tgaaaataaa 2627221 actaaacaaa cctttttcag ctgtttgcgc ctttttcatg taaaattcaa tattcgtgct 2627281 ggccgaggga tcaacatcgg gatgacgcca gccgtcagtt gttcccccga caccgtgaat 2627341 catggctcca aactgaataa aatctgcacg tgtcatcttt ttgcctcctt tatctgtgca 2627401 tgattagcaa gtgcaagatc aaggtgttca atgccgattt cagttatccc ttgatactga 2627461 ttgccgcgcc cgatttcgac cacaggcaca tggcgcaccc catatttcac ctgtaaaata 2627521 tcccgaagct tttctttctc tgaaacatcg atattttgga acgggaaccc tttttcattc 2627581 aaataattct tgacttcctc acaatacgaa cagccttttt tactccaaac cacaatgttc 2627641 acaacatcac tcattcttct gtccctcctt aacgttttgc agctaaaact gcatcgctca 2627701 gcagctgata agacagctgt ttttctacag catttttgat cggtgtaaaa ataacaaaat 2627761 cattgatttt gtatgtgcct gataaacgtg ttaattcttc tgccacttct tcctttgttc 2627821 cggcaataat cccggttttt tgcacgatga tgtcataggg ctctgtgacg ttttccagat 2627881 aggcctcagc ctgttcgcgg gaaccgacgt tgaccttacg cccgtctttc aaaaccactt 2627941 ttatcgattc acgcgacaca atatgttttt ccgcttcttc ttttgtatgt gccgcaaaaa 2628001 cagcgggggc aagatgaaat tcagcctcag atcctggcgg gagatgcgcg tcaaatgctc 2628061 ggcgggcttc cttcagcact tcctcttcac cgttaataaa gtaagcaaag acaaaagaga 2628121 ttcccagttt tgcagcagaa atggcactct ctgtgcttcc tcccaataga aaaatacccg 2628181 gcttccgatc aacctgcggc ctaggacgca atgcggcata gcggtgggta tcaggaaaat 2628241 catcccgaac gaaatgagta agctcctcca gtttttcatc aaactgacgc accggttttt 2628301 tatattcggc ctgcagcgcg tctgtggaca gctgaaaccc gccgggcgct ttgcccactc 2628361 caagatctat acggccggga gctaacgctg atagaagatg gaattgctcc gctactttat 2628421 aagagctgta atgctgcagc atcactccgc ctgatgctaa acgaattttt cttgtgcttg 2628481 cagcaagata gcctaaaaga acctcgggtg cagaccctgc aatctcatca ttgttgtgat 2628541 gttcggccac ccaaaatcgg tgatatccac attcttcagc catttgtgcc aatttcactg 2628601 tatgctgtaa tgtatcagct gctgtctccc cttcaccaat caagctttgg tctaaaatac 2628661 ttaagcggat catatcaccg gctcctttat gtgttctttt ggttcaaata aatattccgg 2628721 cgaaacacgg cggagaaact gcctcgttct gtcttttttg gtatggcgga agacttcctc 2628781 cggggttcct tgttcaacaa tgactccttc atccataaaa acaacttgat cagagaccct 2628841 tcttgcaaac tccatttcat gtgtaacaac aatcatggtg gctccggttt tcacgatttc 2628901 cagcattacc tcaagcactt caccgaccag ctccgggtca agcgctgccg tcggctcatc 2628961 gaacagcagc acatcaggat gaatggcaag cgcccttgct atccctaccc tctgcttttg 2629021 tcctcccgat aactgactcg gataagcgtt caatttatct tgaagcccga cctttctcag 2629081 ttcattttcc gctacggcat acgcgtcttg ttttctcatt ttccgggcaa tcgtcaagcc 2629141 ctccatgaca ttttcaatca ccgttttgtg agcaaacagg tggtattgct gaaataccat 2629201 tgccgtctgt tttctgagcc agtgaacctc ttttttggac ggaaagcggc aattaatcac 2629261 tttgtcatgt atagaaatga tcccttcgtc tggacgttct aataaattca ggcaccgtaa 2629321 aaaggtggtt ttccctgatc cgctcggccc gataatcgtc acaacttctc ccttgcgtac 2629381 cgtgagattt atccctttta atacatggtg gatgccaaac tgtttatgga tatttttaat 2629441 ctcaatcata aagtgcctcc ttgaaatctg gctgcctttc tctctaatac tccatttgcg 2629501 gattctagga ttagagtcag cacccaatag ataatcgctg ctccgataaa cgcttctaaa 2629561 aatgcataat tatcagaagc aacgatagtc gccgtccctg taatctctgg gacagccact 2629621 atagccgcga tagaggtggt atgcaaaaag ccgataccca aatttgtgaa gtttgggatg 2629681 gaaaccttca gcgcctgcgg caatattaca cgccgaaagg tttggctgta tgtcaagccg 2629741 attgaataag ccgcttcgac ctgtccggta tccatcgcca gaatgcccga ccggatgatt 2629801 tctgtgagat aagctccggc agttaaagac aaggccatga tgacaaacat ggagaccggt 2629861 atctcattag cggaccagcc gagatgaaaa aaactgctga cttgatctgc aacaggcggt 2629921 atccctaaat aaatcaacat aatgtgaaga attgcaggtg tacttcgaaa gaaagacaca 2629981 taaaaccttg agcaagccac caagccctta attctaaaaa ttctaacaat tatatttcca 2630041 agagccacga gaaatccaaa cacaatcggc aaaacagcca tcatcaatgt cagaggaatg 2630101 gtctttacca tttctttcat ggcggaaacg ataaatggaa agtcaaattg caatcttctc 2630161 ccccctcatc cgaagaaata tatcaatgta tgttcatgtc aaaaacagta acaatccttg 2630221 tttgattctt cttgattcgt ttttctgcca ctcgaaagaa ccattcgaat aaaaccgcta 2630281 cagcataata aacaatcgat agcgcaatgt aaacttcaag agaatggttg cttgaggtaa 2630341 tcagtgtttg gccccttccg gacatatcca taacacctat tgaaaaggct agagacgtat 2630401 cttttaaaga actgatcacc atgtttccca tattcggaaa cgcctggaca agtgcctggg 2630461 gcagaacgat tcgcctgaag gcctgactac cgcttaagcc aatactgtac gccgcttccg 2630521 tttggccttt atctacactg cccacccccg ctcgaatgat ttctgcggct gccgctgcat 2630581 tgcttaacgc gtaggttgcg acagcagcat aaaacgggtc catttttgat gtatcaatcc 2630641 cgataagccc cgtaagcgcc gggatcccgt aaaacacgat gaaaagctgc accatgatag 2630701 gcgttcccct gaaaaacgag atatacactt ttgccaattg atttacaatt ggaatattat 2630761 agatgcgggg cagtgccaga aagagtccta atacaaaacc gaaaagcaag gacagtgtta 2630821 aaatgtataa tgtaaccggt aaataagcgg ttaacgtcgg cacaaaatct ccaatcatgt 2630881 tcatatcaaa cgctttttcc atcactgctc cctctctttt tacctaatac tgctctttgg 2630941 aatagtcgtc accaagccat ttcaaactga gccttttcaa cgttccgtca tcaatgattt 2631001 cctgtaaggc tttatcaata tcgtcactta acgtttgttc atttttgtta aacataaaat 2631061 acactttggc atttgaaagc acattaccga cggttttttc tttaatagtg ctcgtcttgt 2631121 tttgaaagtc tactgcaaaa ggcgttgaga tcgttgcgtc cgcacgcccc gatttcagct 2631181 gattcgcagt ctcatttgcg ccttggccct cataggcaat ctcaaacggc cgtccattat 2631241 cctcattcca ttttttcagt acaagcgctc cgttggaggt tgcactcgta atcacccgtt 2631301 ttccttttaa gtcttcaatt ccacggatcg tatcgttatt ttgaagcaca gtaattttta 2631361 aaggaaaatg gttgtaagca accttgttaa acagaaattt tttctcacgc tctttgcttt 2631421 tctccatttg atgtgccacg atatcgactt tatgctgtcc gaggctgaca agcaggttgg 2631481 aaaattccat cgttttaaat gtgaatttat aatgtggcag gcgcttatca agctctttga 2631541 tcagttcgac atcataaccg gttaaatcgc ctttttcatc gataaagcaa atattcggaa 2631601 attgggttcc agttccgacc gtgatcgtct gtaccttctt ttgcccggct cccgtcgttt 2631661 gactgcctgc accgcaagct gacagaactg ttataagcga aaataatatt gccatgaatg 2631721 ctgttttcgt tttcatctca tcgccccatt tatttttcaa aacttgattt tgaataatct 2631781 gccccgagcc attttcggct tagttttttt agcgttccgt ttttctccag ctttttaatc 2631841 gcttgatccg tgtcatccgc caaggtttgg ctgcctttat taaacataaa gtacacctcg 2631901 gtatctaata acacgtcacc gactgtcttt tggcggaagg cgtgcgtttt attctgaaaa 2631961 tcgacggcaa acggtgtagc tatcgttgca tctgcgcgcc cggtttcaat ttgattggcg 2632021 gtatcattgc ttccctgtcc cgcatatttc aaatgaattg ggctgccgtg cgttttgttg 2632081 tactttgtaa tataatctgc cgcatttgac gtggcgccaa ctatgactgt ttttccgtgt 2632141 aagtctttta atgtatgaat cttgtgatta tcctctttca ccgtgatgta catcggcgag 2632201 tagttatatg ggactttatg atacaaaaaa cgcttttctc gttctttatt tttggccata 2632261 ttgtgcgcaa tcacatcaat ttttttattt ccgagactcg tcagcaaatt tgagaaatcc 2632321 atcgttttaa attcaaatgt atattgaggc aactccttat cgatggcttt catcacttca 2632381 atgtcatacc cggtcaattc acctttttca tttaaaaacg caatattcgg aaaatctgtt 2632441 ccagtgccga ctatgaccgt ttgagcctga cgatctgttt tgttatttgt ttgcgaacat 2632501 cccccgccaa gtaatgcaaa cactgacagc agcaaaacca atcctttacg cttattcata 2632561 ggctgcctca catcatgccc agctgggcgc acctaaaagc gttgggttaa atcgttccgg 2632621 aatcagaacc ttgtgcatca tcacacctat gtccccgtct ttttcctgct caaaatacac 2632681 ttcataccct ctccttctgt acatgtcagc aagccaagga tgcttgcgcg ccgatgtgcc 2632741 gagtgtcagc gcaggagcct tcagcatatc tcgaagcact ttttcttcaa catacgtaag 2632801 cagcttactt ccggcgcctt gccctttata ttccggcagt gtcgcaaacc accacacaaa 2632861 tggatatttt gaaggaggcg tctcactctc ccacgggaac ctgattgtaa tcgttgaaat 2632921 cagcttccca tcccgctcca gcacaatcgc tgaatgatgt tcaatatttt ctgataccat 2632981 ttggatatca gctctcgtgg atggccaatc aatatccagc tgccgaatgg gctgaaatgc 2633041 gctgttaacc agtttcaaca gctccgatgc atcttcaaca gttgccagtc gaaaaatatc 2633101 atcactcatt tttgtcactc ctcttcacaa aatatataat tcctatttgt ttactaagct 2633161 tttattgttt atactataaa gcatactctg atctttgact aatcaaaaaa agtaaacctt 2633221 cacttcagta attttaatga tgaaaaacag gagggagcac attggagtta cgctcaatca 2633281 aaacgtttca tacgattgta aaatttggaa gcttctataa agctgcagaa atactcaact 2633341 actcgcagcc gacgatatcg atgcgtatga agcaattgga gcaggattta ggcgtactgc 2633401 tgtttgaaag aggaaaaagc ctgcagttga caaaagcagg gaagcttttt tatgaacgaa 2633461 caggagatct tttgatgcaa tacgaggcgc ttaaacacaa cctctccgac ttaaaggaag 2633521 aagaggcagg cattatcaac ataggggttt cagagccaac cgccagtctg atattccccg 2633581 agattttaaa ggatttctta atggattacc caaagataac ggttaatatc aaggttgatg 2633641 acgccaatac ctgcagtcaa aagctcttag acgggacgat tgattttgca gtctgcggcg 2633701 agccggagct gattcttgaa aattactacc atccattttt ttatgacaca ttaaatgtga 2633761 ttgtatctga tcaacatccg ctcgctgaga agaaggctgt ccatttgtct gatttagcag 2633821 aagagcgctt catatttacg cccgccaatt gccccattcg cttacaaatt gaacagcatt 2633881 tacatagaga actcgggaat cgctacaaaa aaatggagct cacaagcagc atgtcacatg 2633941 aatattacgt acgtgaaaac atcggaattt caatctttac cagcaccgca cattctaaac 2634001 cgttcaacgg cactaaagtc attccaattc tgaacctgga tatcaccccg cccatagggc 2634061 tgttgacaaa tcaaaaagaa gttcattttg accgcgccac gaaggacttg atcgcccgga 2634121 taaccaaacg ttttcagcag cgcagcaaag aattggaagg aacctctgat aagaccatta 2634181 caggataact gaaaaaataa aaaccacctc ctgattcatc aggagatggt ttcacggttt 2634241 aaagctcgat cgtctcaccg accgacatga ctttgccgac tccgcccggc aggctgtcag 2634301 cgaatgcttc tgggtcttgt tcgatgaccg ggaatgtatt gtaatgcacc ggcacgacct 2634361 gttttgcgcg cagccattca gcagcaagct tggcgtcttc aggccccatt gtaaagttat 2634421 cgccaatcgg aaggaaagca aggtcgatat gattcaattc gccaatgagt ttcatatcag 2634481 agaaaagtgc cgtatcgccc gcgtggaaaa tcgttttatc ttctacagtc agcaaaatac 2634541 cggcaggcat gcctgtgtaa gtgatcgttt tgttttcttc atctgtgatg gctgatccat 2634601 gaaaggcctg tgtgagcttc acttttccaa aatcgaactg gcgggagccg ccaatatgca 2634661 ttggatgaac attcaagcct ttccagccta agtacacagc gagctcgttc ggggctataa 2634721 ccagcgcgtt attttgcttg gcgatttgtt cagtatcacc gacatggtca ttgtggccgt 2634781 gcgttagtaa gatgacatcc gcttttacat cctccggctt tatatccgtt aatgaattcc 2634841 ctgttaaaaa cggatcaaaa ataatatgat ggtccttcgt ttccactgtg attacagaat 2634901 gtccgtgata tgtcactttc atttctttca cctcgtcaca tgattttgtt ttttttattt 2634961 tcccttttta aaaagctgaa aaacttatgt tgtttgattc ttgttaatga cattgaggcc 2635021 tccggtggct tcaatgacag tccctgtcac aaggtctgag ttctcctcac acaagaaagc 2635081 gataatcctg gcaatatcct cgcctgtacc ggatcttcct atcggcgttt tttctttgcc 2635141 gattcgcatt ctggcttcct ctatcgatgc ttctttcatg tcgccgacaa tgtctcctgg 2635201 gcaaaccatg ttggcggtta tgccgaattc ggcttcttca atggcaattg tcttcgtcaa 2635261 agaagccaag cccactttcg cagcgccaaa tgccgatcgg tgaagccagc cgggcgcgtg 2635321 agccgcacct tggaatccgt acgtaataat gcgtccaaat tgctgttttc tcataatagg 2635381 aataaccgct ttgaataaat gaaagacggc gcttaaattt ccttccagca tgccatacca 2635441 ttcatcatca gtataatcgg ctaacttttt acgttcaaat atgtatggtc cagcgttgtt 2635501 aatcaaaaag tcgatccttc cgaagcggtt taaggcagcc tctgcaatac gcagcagatc 2635561 ttcttttttg gtgacatcac cttttacaaa ttgcagccgg tcaagacaat cgggacaggc 2635621 ttccttcagg cggctgactg cctcctcatc ctgtctgtaa ttgactgtta ctgaataccc 2635681 ctttgcaagc aacgtttcag tcactttgcg gcctaaaccc ttcgaaccgg cagtaattaa 2635741 agcatgtcgc acatgaatac ctcccaaagc aacgtcgccg ctttcaataa agtgtttctt 2635801 cttctacttt actataaaag gcttgcaata tcacttttta cactttggca tacaaaaaaa 2635861 gctgcctgta cagacagctt attctgcagg agatgaagac tcctgatcag gcatatcgac 2635921 ataaccgctt tgatatgctt ctgaaatgag ccttgttgtc tcctggcttt cttgttcatc 2635981 ataaatatag cgttccggtt cttttttcat cattctgcct cccatcatta tagaggtagg 2636041 ttggctataa tgacgggatt ttatgaagga aattttaaca aactcctgct gccacgcaag 2636101 ctttcgcttt ttcaagcgcc tgttccacct gtttgaatcc ggtgcccccg gcgctcattc 2636161 ttttttcaac tgcgtagtaa gggtctaaca cagtgtaaat atcttcttca aatagtgtgc 2636221 tcgcctgctg aaactcgcca aacggcatat cgcttaaata gatccctctt tcgatgcatg 2636281 tgtacacaag tttcccgacc acttcatgcg cttctctgaa cggcattcct tttttagcta 2636341 aataatcggc cagttccgtc gcgtttgaaa agtcttgttt tgttgcttgc ttcatgacgt 2636401 ctttgtttac agtcattgtt tggatcatgc ctgtgaagat ttgcaggctg ccctccaccg 2636461 ttttcaccgt gtcaaacatg ccctctttgt cttcctgcag atctttgttg taagcgagcg 2636521 gaagtccttt catgatcgta aacagcccca tcatatcgcc gtatacgcgt cctgttttgc 2636581 cgcggatcag ctccgccata tcagggtttt tcttttgcgg catcatgctg cttcctgttg 2636641 cgtacgtatc gtcaagctcg atgaatttaa actcctgcga gcaccataaa atgatttctt 2636701 cagagaaacg ggataggtgc atcatcagca tactgctgtt gcttaaaaac tccaaaatga 2636761 agtctctgtc gctgacgccg tccaagctgt tttcataaat ggcatcaaag ccgagcagtt 2636821 ccgctgaata atcacggtca attgggaagg ttgttcccgc gagcgccccg cagccgagcg 2636881 gagatttgtt aatccgcttc attgaatcct gaaaacgctc cttgtcgcgc tcaagcatcc 2636941 agaaatacgc aagcagatgg tgagcgaatg aaatcggctg ggcgcgctgc aaatgtgtgt 2637001 agcccggcag aatcgtttca acgttcgctt ccgccttttc aatcagcgca ctttggaatg 2637061 cctcaatcag ctcgatgatg tggccgacat gattcttcaa gtataaatgc atgtcagtcg 2637121 ccacctggtc attccggctt ctgccggtat gcagcttgcc gccaagagga ccgatttcgt 2637181 caatgagcat tttctcaatg ttcaaatgaa tatcctcata atcgactgag aattccaatg 2637241 ctccctcctc tgctttttgc aaaagggtat tcaggccctc tcggattttc aactcttctt 2637301 ctgctgtcag aataccgcat tttttcagca tggcagcatg tgcgagagac cctgtaatgt 2637361 cttcagcaac taaattttgg tcaaatgata tggacgcgcc gaactcgtcg acccattttt 2637421 ccggtgtttt ttgaaatcgg cctccccaaa gcttcttcat gctttaatct gctccttctt 2637481 tttcacgatg ctgttcactt ttgtcggaag tccccaaagc tcgataaatc cgattgctgc 2637541 atggtgatca aatgcatcgt cttttgtata tgttgcaagt ttttcatcat atagagagta 2637601 ttccgattta cgtccttcta caattgcatg gcctttaaac agcttcacgc ggacaatgcc 2637661 tgtgacatgc ttttgcgttt cttttaagaa agcgtgcagc gcgtctttta acggtgagaa 2637721 ccataagccg ttgtaaatga tttctgacat tttttgctcg atgatcggtt taaagtgggc 2637781 tacctctttc accagtgtca aatcttctaa ttctttatgc gctttgatca gtgtcatcgc 2637841 accagggcat tcgtatactt cccgggattt aatgccgacg aggcggtttt ccacgtggtc 2637901 gatacgtccg acaccgtgcg cgcccgccat ttcattcagc ttcaagatca gctcagaaag 2637961 cgagtaggaa acaccgtcaa tggagacagg cacgccctgt tcaaatgcaa tttcaatcac 2638021 ttccggcgtg tccggcgttt tttccagcgg agctgttaaa tcgtatgcac cttctggcgg 2638081 cgccgcccat ggatcttcta aaatgccgca ctcattggcg cgtccccaga ggttttggtc 2638141 gatagaatac gggctgtcaa gattgatcgg aatcggaatg ccgcggctag ccgcatattc 2638201 aatttcttct tcacgtgacc actgccattc gcgaaccggc gcgatgactt ctaggtcagg 2638261 gtttaatgat ttaatggaga cttcgaaacg aacctggtca tttcctttcc ctgtgcatcc 2638321 gtgggcaatc gcctgtgcat cttctttttc cgcaatttca accagttttt tcgcgatcag 2638381 cggtcgagat aatgccgaaa caagcgggta ttttccttca tacattgtgt gggcctgcaa 2638441 agagataagc gcgtaatcct gtgcaaattc ttcttttgca tcgatcacgt aggagtttgt 2638501 cgcgccgact tcaagcgctt tctgctgaac aaatgccaaa tctttgccct caccgacatc 2638561 caggcagcag gcgattacat tatatccttg ctcctgaagc cattttattg cgacggaagt 2638621 atcaagacct cctgagtatg ctaatacgac ttttttctgt tctgacatga taaaaatccc 2638681 ctctcaaccg tgtttctatt ttgtataaaa ataaattata tttaataaaa atacattttg 2638741 tatgtataca ctttaacaag tacgtttcgt tttttcaagc cttttataaa aaaaacttca 2638801 cctaaatttc aggtgaagtt tcatagtatt tattcattta cttgtctttt ctgatttctc 2638861 tgaccacatg cgcaagttcg ggaataatca gcttattcat tgccagcttt actgcgccgc 2638921 ttgagcctgg cgttgagaaa acagcggtat gctgaatgac gccggcagtt gctctcgaca 2638981 tgattgcggc agagccgata tcctctgtat aactcagcat cctgaatatt tctccaaagc 2639041 cgggcagttc tttcgaaaac agcggcgtta tggcttcaat tgtgacatcc cgatctgcta 2639101 tgcctgtccc tccgtttaag agtaccgcgt ctgtctgttc atccatgcag cccgcaagca 2639161 ctgaccgttg caaagcatcc ttttcgtctt ttacaatttc atatgcggca atatgatgac 2639221 cggcttcttc taaaaatgag atcatcagct tgccgctttt atcggtttca tctgtcctcg 2639281 tgtcactgac agtaatcact ttgcaccgaa cgatatcggg agcttcttgt ttatgctctt 2639341 gaacgctcat tggcccacct cttttatgtt ttctgtctgt cactatcatg catcaacaaa 2639401 aaagcacatt caagagaatg tgctttcatg cgatttattt tgctaaacga acaacgtcgc 2639461 gcgcaatcat gacttcttca tcagtcggga tgatcatgac ttttactgga gaatgcggat 2639521 agctgatgaa agcttcctcg ccgcgcacgt tattaagcgc agggtcccag tatacgccca 2639581 tgaattctaa accgcgaaga acgcgttctc tgacttccac actgttttca ccgataccgg 2639641 cagtaaagat gatcgcatct acaccgctca ttcttgcagc gtaagaaccg atgtatttgt 2639701 ggattctgct tgcgaatact tcaagagccg tttccgcgcg ctcatttcct tctttcgtag 2639761 cttcaacgat gtcacgaaga tcgcttgaga aaccggaaat gccgagcagt ccgctttttt 2639821 tgtttaatgt attcagtact tcgtcagccg tttggcctgt tttctccatg atgtatggga 2639881 tcagggcagg gtcgatgttt ccagagcgtg tgcccattgc tacaccggca agcggcgtaa 2639941 agcccatgga tgtgtcaata gattttccgc cttcaacagc ggcaatactt gctccgtttc 2640001 caaggtggca ggaaatcagg cgcaagtctt ttaacggacg gccgagaagc tctgccgcac 2640061 gctcagttac atatttatgt gaagtgccgt ggaagccgta tttacggatg ccgaattttt 2640121 catagtattc atacggcaag ctgtaaaggt aagactgctc aggcattgtt tggtggaatg 2640181 ctgtatcaaa tacagctacc gcaggaacat ttggaagcac ttctttgaac gctttaattc 2640241 caacgatatt tgccggattg tgaagcggtg ccaattcaga aatatcttcg atttccttaa 2640301 tggtttcatc cgttaataaa acagaatcgc tgaatttttc tccgccgtga acgacacgat 2640361 ggccaattcc gtcaatttca ttcaagtctt taataatgcc gaattccgtt aacttattca 2640421 gcagcatttt aacagctacc gcatgatctg gaatatcagt tacttctgta tttttttcgc 2640481 cgttcacaga aattgtgaat acgctgtcgg cgataccgat tcgttcaact aaacccttcg 2640541 ttaaaacggt ttctgaaggc atttcgaaaa gctgaaattt caaagacgag cttcctgcgt 2640601 taattgcaat aattttggac atgattgacg ctcctttata ctctgtatca acaacttcgt 2640661 ttttcgtact tttttcccgg tgaatatcaa catcttctcc gaaaaatatc tgacttttcc 2640721 atttaaacat tgtcatgtcg gcttttcaag tcaacttgcg tattgataac gcttacaata 2640781 agaagtcgtt attttcagac acattcacta taggttttgt attgatgaac gcttacaatt 2640841 tgcggttttt ccctctgtat tttgtgtttc aaagctggat tcaattcgtc aagtccggtc 2640901 ttcaaaagca taaataaaag cagcttaggc atcgacctca tacggctgtc taagctgctt 2640961 ttaaaacact tacttttctt ttttaaacca ttcatcaaat tgagccatca tatcaagcat 2641021 cgccttttga ttggagaaag acggaagatt cgcaagcaga atttgccccg gcgctttcgt 2641081 attctctcct tgtttctgaa gcacaaggat gcttttggca tgagcttcgt ctttaaaaat 2641141 agattttggc agctgcaaca gtgcgttgat atgaacctta tctttgaaaa actgtttcag 2641201 cttgccgctt tgggagctct caaacaaatg attcggaatc ataaaaaata agtagccgcc 2641261 cggtttggta tgcttgacgc tctgttcaat aaacagatga tgagcgaagg aatggccttc 2641321 gtcagctttg agctcaaacg cttctgctcc ttcgtcattc ggataatagc cgactggcag 2641381 atcacaaatg accgtgtcaa ctggatcgat aaacaacggc tcaaggctgt cctggtggaa 2641441 aagctcaagc tcttttttca gaaggttcgc ttgggcatag gcgatcttca agagcacatc 2641501 atcaatttca atgccaaagc tgtttgccgt tttttcagac agctggttca gcacggtaaa 2641561 cagaaggttc ccagttccca gggctggatc aagaatggtc agttcctttt tgtccgccat 2641621 aaatttattc accaaatagc tgatgaaaag cccgatcgta tccggcgtca tttgtctgtt 2641681 tggatgcgag atatctttca ttcctttaag gacggcaagc tgaaaagcct tgcgtaccca 2641741 ctcatgctca tacgtgccga attccgcttt ttcaagcaga gcctgaagtt gtttggtttt 2641801 ctgatcagca ggcagtttca gctgatccgt tttttcaaga aaatacattt ctcctgcttc 2641861 ggccagcgcc tctatatatg aaatctgcaa ttcattcttt atcataatcg cggcttcgtt 2641921 taacagctca tacaccgcac ctacatggtc tttttgcata ttgtgttcct ccttgccatg 2641981 aaaaaagctc cggcggcagc ctggagcttt tttccctgct tactttacta atgccttagc 2642041 agcctcaatt ggcttttcat agttcgggtg gtttgttgct tcgcttacat attcagcgta 2642101 aacgactttt ccgttctcat caaggacaaa tacggaacgc gcaagcagac gaagttcttt 2642161 aatatacaca ccgaacgctt cgccaaatga catatctctg tggtcagaca gtgtttccac 2642221 tttgtcaatt ccgttagcgc cgcaccagcg cgcttgcgcg aatggaaggt ctgcactgat 2642281 tgtgtagacg ttgacatctc caagctttgc agcttcttcg ttaaaacggc gtgtttgtgc 2642341 atcacaaaca cctgtatcaa ttgaagggat aacagaaata atcgttacct ttcctttcat 2642401 gtcagctaac gatttttctt caaggctgtt agtcagcact gtgaaatcag gagcttgatc 2642461 tcctaccttc acttcttgtc cgacaagtgt aaccggaccg cctttgaatg taatttcagc 2642521 cattataatt cctccctttt gtatgtatgt ctctatcata gtaaagtttc ctgcaaactg 2642581 caaagtttat gccaaaaaaa agttaactgc ggccagcgca gttaaccttt ttttaataat 2642641 tcatattgtt catttggttt tgattttggc cttggctttg gtttttgtta tttttcttga 2642701 acatttgctg gatgcgctcg agtgtttgag gggctgcgtc taaaattttc tctattaaat 2642761 gggtattttc atctaaatga agcattctga tgcctgtcga tccgacaatt aaaaacgcga 2642821 tcggcgtaat ggacacaccg cccccgcttc cgcctccgaa aggaagtttc tgttctcttg 2642881 tctcatcgtc ttccgatttc ttttcggccg gctttccgcc aaactcgctt ccgcctgcgg 2642941 cgaatccgaa tccaacttta gaaacagtta aaatcacact tccatcaggc gtttccactg 2643001 gatctccgat gatggtgtta acatcaatca tttccttcaa gttttccatt gcggttttca 2643061 ttaaaccttg gatgggatgg tctgccatat acgcttcctc cttaaactga tgaatcattc 2643121 tttgaagtca ttctagccga cggattcttc tttaatacgg atagctcccg tccgtatttg 2643181 acgaatttga aagctgcaag catagcatgt ccaaagcgaa aaaagaatat acactgaaaa 2643241 tgggtcttgg aaacagggac ttgaaacgac gggatcacct catagacagg tttattcaca 2643301 aagtccaggt ggtcgtagag cattgctgcg ataccgccct tcacgcccca tacagcaccg 2643361 gttaacacac ctgtcactgc cgcgtcctga attccgatta ctgtaaccca ttctagtttt 2643421 gtgatatgta aatgcgcgag aaaagacgcg ctgattttcc gcagtctggt gacctgatgc 2643481 aaaagcattt cgattttatt aatgctttgc tgcacatcgt tttgtgtaat ttttttcttt 2643541 ccgctgcttt ttttcatttt ggattcagtt ttttgtttga tatccactgt tccgtcttct 2643601 ttgttcacct taatcgccgg gattgttttt ttgatcctta taaggccaaa cagcgccgta 2643661 atcttcaagg tcaatttgtc attatcatcg gcatgaagat actccagcgc gacatggatt 2643721 ttcattctga gaagcagtac gatccctatg agaataagaa tggctgtcag tacatacacc 2643781 atattcttca cttcctctag gagcattatc gccaattcct aaaaaaataa acccggacgg 2643841 aagtccgggt tatcggttat ttgcggtata atttttcatg caccacggtg gtatccgcga 2643901 tgtaatcatg aatcccttgt tttgtaggtg aaaaggcaac aacgatatat aaaatccaaa 2643961 tcttatcaat ataccgtcca accacttcac gaaaaatcac tgtactccat gtcagcttgc 2644021 tatcttgctt cacagaaacc actttgaggc cgaacaccat tttaccaagc gtctgcctga 2644081 agtattttgt catgagtgcg aaataggcaa gatacacaat aagcgttgtc acactgtagg 2644141 ccgagaaggt aaacatgccg gatgttttcg gcagatccaa tacggtaaag aggggagaaa 2644201 cgagcaaatg gtttaatccc catatcacga gccaatcaag caggaaagcc cagaaacgaa 2644261 cccaaaagcc agcataggca tgtgtcagca gctccgcttc ttgcgggcct ttgatgtcat 2644321 tgcgctctaa ctcttcatat gtcgcgtcca ttattgttcc ctcctacttc gcatagagat 2644381 acatcattct cggcgaaccg gattgcgata gaatttctct catattcaaa aaatcaattt 2644441 cacttttaaa cattttgttc gcgcccatgg aaaacagtga gcctaatccg aagctttcct 2644501 cataagaaat gacagaggcg tttttcaaat ccttgtgatc ctttttcatg gccgtaatgg 2644561 tatcgtcata aaaaccaagc tcatcaacga ggttcagttt tttcgcctgc cgtccgtcat 2644621 acacgcggcc gtccgcaatt ttctttacct ctgctttcgg catgccgcgc ccttttgaaa 2644681 tgacatcaac aaagccttca tacgaattat caaccatcga ttgcatgatg tttttttctt 2644741 ctttcgtcat ctcacgggaa ggagacataa tgtccttatg ggccccgctc ttaatcgttt 2644801 caaaagaaat gccaagcttg tcggcaagct ttgaataatt gacgctttcc ataatgacgc 2644861 cgagtgaccc ggtcagggtt tccggtgtcg caaaaatctt atcagccgct gttgagatgt 2644921 aatagcctcc tgatgctgcc atcgaaccca ttgacacgta aatcggtttt ttcgtttctt 2644981 tcttgatttc ttccagtttc ttatgtattt cagcactttc atacactccg ccacccggag 2645041 aattcacctt cagaacgata cctttgaccg tcttgtcatc ttttgcgcgc tcaaggtttt 2645101 ttaagaacgt tctgtggtta tatccgtctg caccaagcag actgcttgag tccccattat 2645161 cctgaatggt gccgctgacc tctaatacgg caattttact tgagggactg ccgttttcca 2645221 gcgtcttctc ctgcgattca tccgtcagtg atgtgagatc cgtttgagcg cctttgacgc 2645281 tttcaaagaa actcatagag atgctgacga taatagacac gccgaaaatc cccagagcaa 2645341 tcactaatgc aatccatctt tttgcattca ttttttctcc tcctttttcc taaactctct 2645401 cattatacga ttcaatatga aaaatgtttc acttcatgag aaagctccgg cttaacgggc 2645461 tgccggcaaa cgtggtacac ttatggccaa aggtatttta tcacaaatac tggatggcag 2645521 aaaaacttaa atatgacagc aaaggggaaa tgggatatga ccgatcaacg ccgtaatgtt 2645581 tatttttttc acaaacagga tcaggaaacg aacgaacaag cccgctcgtt aacacaatta 2645641 gcggaagagc atggatttac cgttgtgaac cagcactcag acgccaatat tatcgctagc 2645701 attggcgggg acggcacatt tttgcaggca gtcagaaaga cgaattttcg tgacgactgc 2645761 ttgtacgtcg gcattaccaa aaaggggaaa gctcatttat attgcgactt tcatagtgat 2645821 gagcgagaaa aaatggtcga tgcaatgacg tttgaacaaa ttgaagtgag aaaatacccg 2645881 ctgattgaag tgacagtgga tcaagccagt ccttttcact gcttaaacga ggtatccatc 2645941 cgctcaagca tcatcaaaac ctttgtgatg gacgtgctga ttgacgatct gcactttgaa 2646001 acgtttagag gtgacggaat gattatctca acgcctacag ggagcaccgc ctataacaag 2646061 tctgttgcag gagctgttgt tgatccattg cttccatgca tgcaggtatc agagcttgca 2646121 tcccttaaca ataataccta ccggacactc ggctcgccat ttgtcctcag ctctgaccga 2646181 aagctgaccc ttcgtgtggt gcaggacggc aacgaacacc caatcatcgg cttggacaat 2646241 gaagcactca gcacgagaaa tgtgaaaacg atcgaaatca aactgtctaa taagaaaatc 2646301 aaaacagtca aactaaagga caattcattt tgggaaaaag tgaagcgtac ttttttatag 2646361 aaaataaaag gacaggctgc tgcctgtcct tttatgattt ctcatataca atctggccgt 2646421 taatcacggt ttttttaatc tctaaaagat gaagctgtgc ggggtcaatg gcaaacggat 2646481 caccactgag aactgtaaaa tccgcgtcat agccttccgc aatttttccg cgtgacttct 2646541 ctttataaat gataccggcg ctaccttctg tataaagctt tatcgcttca tatacaggta 2646601 aacattcact ttcattatag cttggcccgt tttgctcatg actgcttttc cggaggaccg 2646661 cggactggat ccctagaagc gggtcaacag gctcaatcgg ggcgtctgaa ccgcccgcgc 2646721 ataaaatgcc tttagatatg agggttttcc aggcaaatgc agtcttcatc cggtcttttc 2646781 cgagacggtc aatgacccac ggaaagtcgc ttgcaacgaa gtgcggctga aggtcaagtg 2646841 cgatcggcat gcgtgctgct ctctcgatta attcgttatc aagcacttga gcatgaataa 2646901 gccgatcatg ccggccgttt ttgggcggat gcttttctat tgcgttcagc actttttcaa 2646961 aagcaagatc gccgattgca tgaacagcaa cctccatccc tttttctctc gctttgcgaa 2647021 tgagccggcc aagggtttcg tcatcgtgaa cctgaacacc atttgttgat ggatcatcct 2647081 gatatggttc tttcaataaa gccgttctcc cgccaagcgc cccgtccgca aagattttca 2647141 tagcaccgaa ctccacatac gggccggaca gcttctccag ctgctcccat cgatcgacag 2647201 cttcatgatg aacgagcaaa tggcagcgaa acggatactt tccgccagcg gcagctttct 2647261 cataagcttt catcggcacc gaaacatcac cataatagga caagtcttcc gaatgaccgc 2647321 ccgtcaggcc ttttgtccag caatccttta ttgcagccgt taatgcctca tcaacatagt 2647381 gctgggagac tggcgggaca gccttcagaa tcaaatcctg cgccttatca aacaggagtc 2647441 cggtcggctc gccatttgca tcttttacga tgactccgcc gtcaggatca ggagtatttc 2647501 ttgaaattcc cgctgcttga agagccgcag aattgacagc tattgcatgc cggcatatac 2647561 gcttgagcaa gacgggcctg tcaggaaaca ggcgatcaag atcatgctta gtcaagtagt 2647621 caggtgtctc aaactgattt tcattccagc cttctccaat gagccaatcg tttttaggaa 2647681 gctgccgctc tctttccttc gcagcctgta aaattgaatc tttcgacgtc agtgcggaca 2647741 gatcgagctg aagctgtttc tcaccgtggc cgatcaaatg tagatggctg tcaacaaaac 2647801 cggggaacat cactgctccg ttcaggctga tttcttctgt ttccggcgac ccgtactttt 2647861 ccttcaaacg ttcatagctg ccggtgcctt ttataacacc atcctcaaca taaactgcct 2647921 cagtccgatc gccttcttcg agcatcgtat aaatgaaacc gccgtgccat atcgccttca 2647981 ttcacgttca ctctctttct ttacgccttt ttattggctt tgagctgttc ttcacgtttt 2648041 cttaattcca ctcgtctgat ttttgcagaa gccgttttcg gcaggctttc cacaaattca 2648101 atttctctag gatatttgta tggagcggta atcgtcttca catggttttg cagcattttg 2648161 acaagctcat cactgcgttt ttcatgattt tgcaggacaa catatgcctt tacgatggag 2648221 cctctgattt catcagggct tgcgacaaca gcacattctt ttacttctgg gtgcttaaca 2648281 agcgcgtctt ccacctcgaa aggcccgatc gtatagccgg agctgataat aatatcgtca 2648341 tttcggcttt caaaccagaa gtaaccttcc tcatcttttc ttgctctgtc tcccgttagg 2648401 aaataatcgc cgcgaatttg tgttttcatt ctttccggat ctttaaaata ctctttaaag 2648461 agcgcaggcg tactgaggtg aacagcgata tcgccaacct caccaggttt gcagatttca 2648521 ccgtcttcat ttatgatctc cacctgattt cccggtgtcg gttttcccat gcttcccggt 2648581 ttaataggcg tatctttcaa aacaccaacc aaaagcgtgc tttctgtttg gccatatccg 2648641 tcccgtacct taatgccaaa gtgcttttgg aaaacatcaa tgacttcacg gttgagcggc 2648701 tcacctgcgg aaacagcgct gtgcagggca gaaagatcaa agcgtttcaa gccttcaacc 2648761 ttcgccatta agcggtattc tgtcggagtg cagcagaaaa cattgatttt gtagcgattt 2648821 aaaagctcta gatatttttc tgctttgaat ctgccgtggt acacaaaacc ggttgctccg 2648881 ctgccaagca ccgctaaaaa cggactccat acccactttt gccagccagg ggcagcagtt 2648941 gcccagacga tatccttttc agaaatgtca agccaagcgc cggcagaagt ttttaaatga 2649001 gcaaatgccc atccatgtgt atgtacaaca cctttcggct gacctgttgt cccggatgta 2649061 taagataaga aagccatatc atctcttgtt gtgtcagctg ttttaaattg gcttccgtcc 2649121 gcttcaattg ataagaggtt tttccagccg gcatcatttt caccaataga cagtgtaatc 2649181 agtttgtcag ccgtactgac atcccggaaa gcgccaataa attcggagta gacgatagcg 2649241 ccttttacct ctgcatgttc aatccggtat tcaagatctt tcgcgcgaag catttcggag 2649301 cacggaatga caaccattcc tgatttcagg atagccaaat aaacagcata ggcttcaagc 2649361 acccgcggaa ccattacaat cagcttgtct ccctttttaa atccaagatc agctaaggcc 2649421 gctccgattt tatttgtttc ttccatcagc ttttcatacg accaagattc ttgcttgccc 2649481 gactcgtcct cccaaagaag agcggttttt tgtccagcag cactgaactt ttccatttca 2649541 ttcactaaat tatattgcac aggggcaatt aaatcttcac gttttaacac gaacaactcc 2649601 tcactttctc cacccattat acataaatac aggctctttc cgtaaggata tgcctaaaag 2649661 caacctctgt aaacatagat tttataggcc gctggtcctt ttttatatgt aaaaaatgaa 2649721 aaagagtggg gataccccca ctcctaagcc attatgtgaa attgtaaatt agaattgtcc 2649781 tccgcccatg ttttgttgag caaaagatac aagacgtttt gtgatctctc ctccaacaga 2649841 accgttagcg cgagaagttg tgtctgctcc aaggtttaca ccgaattcag aagcgatttc 2649901 taatttcatt tggtcgatcg cttgagcagc tcctggtact aaaaggttgt tgctgttacc 2649961 tgagttattg ttagccatgt gtctcacctc cttgtgagta tagaatgtgt caaaacacat 2650021 ggcttcattc agaaaaactt tggtaattgt atacaggagc tgaaaattga tttaaaagag 2650081 ttcagcgaat ttatcgttag cttcttgttc gctataaagg gtcattgtct caatgttatc 2650141 taccgcttct tgaatatacg gctcgaaatc aacaaagctt tcaaagtgtt caattttctc 2650201 ttttttaggg cgtgttttcg ggcttggcgg tgtaaagatc gtgcagcagt cttcaaacgg 2650261 ctgaatactt gtctcatatg tgccaatttc ccgtgatttt tcgatgattt ctgttttgtc 2650321 catggcgatt agcggacgca aaatcggtgt tgacgtcacc gcattaattg catacatgct 2650381 ttcaagcgtt tggctcgcta cctgaccgag gctttctccc gtaataatgg caagcccgtt 2650441 tctcttttct ctgattctgt cggctatctg aagcatgagg cggcgggttg ccgtcattgt 2650501 gtaattttca ggaatttgtt tttggatgag ctcttgcgtt tttgtaaatg gaacaatatg 2650561 aagtgtcatg cttcccccaa aacgggacag acatttcgcc agatccatta ccttttgctt 2650621 tgcgcgctcg cttgtgtatg gcgggctgaa gaaatgaaca gcttctaccg acaatccccg 2650681 tttcatcgca taaaaaccgg ccacagggct gtcaaaaccg ccagaaagca tcagcatcgc 2650741 ttttcctgct gaaccaactg gcagcccgcc tgcacctttt tcatcacgaa ttgtcaaaaa 2650801 tgttgcttct tccctgattt cgattctgag cgggatgtct gggttgcgaa catcgaccgt 2650861 caatccttct gtatttcgca aaatatggcc gccgatttca gcgttcatct ggtttgtatc 2650921 taattcaaat tgcttatacg ctctctttgt cgcgacttta aacgtatcac ctggtttata 2650981 ctgatctttg atagccttta gtgcggttgc cttaatatca tcaaggcggc tgtcacactt 2651041 aattgccagg ctgaagcttt gaatcccaaa cacttgcttt aaatgaggaa aaagagcctc 2651101 aggatcctct ccatttaatg taatcgtcat acgatccctg ttggaaaagt attttaaatt 2651161 cggatagtct ttcaaaacga gtctgatgtt ttgttttaag cgctcaataa agctttttct 2651221 gtttttgcct ttggtcgaaa tttccccaaa acgaattaat atatgatcgt aattcatgtt 2651281 ctacctcatc atttccctta attttttgat gccaggacga agcgcgttca taaacggttc 2651341 tgccacatcg cttgtctggc tgtaatttaa actgattctg atgctgcttc cggcaatctg 2651401 ctctcctttg cccatctcta agagaacctt gctgggctta tgttcttttg ccgagcaagc 2651461 cgatgttgtg gagacgaata tatcctgttc ctcaagcatg tgtaaaagca cttccgcttt 2651521 aatccccggt acagagaaat taataatgtg cggcgcgcta ttcatttgag gcgtgttgat 2651581 aacgacgccc tcaatttcac tcagcctatt cataaacaat tcctttacgg cagtcatcgt 2651641 gtcaagccgt gtgtcaaaat cagcagaggc cagattaatg gccttggcaa gcgaaaccgc 2651701 accagcagta tgttctgttc cggcccgtat gcctttttgc tgagagcctc ccgttatgag 2651761 cggaataagg cgtgttcctt cttttacaat aagtgcgcct gtccccttta ggccgtgaaa 2651821 tttatgcccc gaaattgaac atagatcaat gccggccttt tcaattgcca agggcacttt 2651881 atagatgccc tgcacataat cgacgtgaaa caaaatgttc gaatgctctt tcagcacttc 2651941 tcctgccgct tcaatcggct gcacggaacc gacttcattg ttcacatgca tcatgctgac 2652001 aagcacggta tcgggacgga tggctgcttt tagatcttca atagaaacaa atccgtcttc 2652061 attcacagaa agataagtga tatcaaaccc gaacaactct ttcagctgtt ctaacgattc 2652121 cgtaacggat ggatgttcaa tagaagtggc aatgatatgt ttgcctgttt ttatctttga 2652181 caaagccgct ccttttaaag ccgcattatt ggcttctgtg gcgcctgacg taaatacaat 2652241 atcatatttt tttaggccta aggacctttt gatttgattt ttggctgctt gaagcagctg 2652301 ttccgtttcg gctccatatc ggtgcaaaga tgaaggattg ccaaagtatc ggctgctcgt 2652361 ctgttcatat acgttcaaga cttcatcgta aggcttcgtc gttgaactat tatctaaata 2652421 tatcatcttt tttactcctt tatgaaagcg gtacaaggta tgatatttat gttaccataa 2652481 caaaatttaa tagaaaatta cgaaaaacta gtattgactt ctaatttttt taccatataa 2652541 taagatttgt tcgtttcgtc atattatctg acaattaatt gacagaatat tttaacataa 2652601 ttattaggag gatttttttc atgaaacact cactgcctgt caaagatacc attattattg 2652661 gtttcatgct atttgcgtta ttctttggag caggaaatat gatttatccg ccggaacttg 2652721 gacaagcagc cggacacaac gtctggaagg ccatcggcgg atttttactg acaggggtag 2652781 gcctgccgct tctcggcatt atcgccatcg cattaaccgg taaggacgct aaaggccttg 2652841 ctgacaaagc gcaccctgtt ttcggcacaa tctttactgt cgtgctttat ttatcaatcg 2652901 gaccattatt cgccatcccg agaacaggaa ctgtttcata tgaaattggc gctgttccgt 2652961 ttttgactgg tgtaccagaa agactttctt tattaatatt tacacttatc tttttcggcg 2653021 ttacgtacta tttagcgtta aacccatcta aggttgtgga tcgagtcgga aaaattctga 2653081 ctcccatcaa attcacaatt attttaatca ttgttctcaa agccatcttc acgccgatgg 2653141 gcggattggg cgccgtgaca gaagcatata aaggaacacc ggtttttaaa ggatttttag 2653201 aaggctataa aacaatggac gcacttgctt caattgtatt tggcgttgtc gttgtaaatg 2653261 ctgtaaaaag caaaggcgtt acacagtcta aagctcttgc tgcagcctgc attaaagcag 2653321 gtgtgattgc cgctttaggc ctgactttca tttatgtatc ccttgcttat ttaggtgcaa 2653381 caagcacaaa tgccattggt cctgttggtg aaggagctaa aattttatct gcgtcttccc 2653441 attatttatt cggttcattg ggcaacatcg tactcggagc agcgattaca gtcgcatgtt 2653501 taacaacaag catcggcctt gtcacatctt gcggccaata tttttcaaaa cttattccgg 2653561 cattatcata taaaattgtc gttacgattg tcacgttatt cagcttgatc attgcgaatt 2653621 tcggactcgc gcaaattatc gcgttttctg ttcctatttt atcagctatc tatccgcttg 2653681 ccattgtcat tatcgttctt tccttcatcg ataagatctt taaagaaaga cgcgaagtgt 2653741 acatcgcatg cttgatcggt acaggacttt tcagtatttt agacggtatc aaagcagccg 2653801 gtttttcact tggatcttta gatgtgtttc taaatgcgaa tcttcctctt tacagcctcg 2653861 gcatcggctg ggtgcttcca ggaatcgtcg gagcggttat cggctatgtg ctgaccttat 2653921 tcatcggacc atccaaacag cttaatgaaa taagttaatg tcacagaacg cctgcgttat 2653981 tgcgcaggcg ttttgtaata aaaaaagagc ctgctcatta cactgcgggc tctttttcat 2654041 ggtcgtgatt atctaagcgg atatgtcagc tttgattttt tcaactgcac ctggcgcagc 2654101 cttttctaca gcggcagcgg caatttcata agagtcgtca taatcaaaag cataaaaacg 2654161 tctttccgct tctttcagct gttcagataa aatatgattc tggcttctga accggtttcc 2654221 gaactgaatg attttttcaa tgaggatgac ctgctcgaca agttcctctg attcccggct 2654281 tgccctgttg acgatatctt ctgcttgttt caaatgggct ccggcttctt ccatatttaa 2654341 tggaagttcg tttagttgat tgaccgtttc ttgaatatga tgatgcgcgt tctccagcat 2654401 ctcttgaata tggctcggaa tgcctggaat gttgctagtc ttcagcagtc ttgctgtctc 2654461 agaaattgtt tttttcaaat tgctgagcgt ctccctcgcc tgaagctctt cttttctcag 2654521 cgcttgcaga ttttcacgat actcggcatg ctcttttttc acttcttcaa tttgcttctc 2654581 tattgaagca acttcttcta ctaaaagtga gtaggcgaca tgctctgcat caagcttatc 2654641 tttaacggat gatagcagct ttccaatttc atcaaggcgc ttttcaaaag cctgctgttt 2654701 gccgagctca ccggctgtca gcctgtagct ttccttcacc agctcagttt ccgctttcgt 2654761 atgctctttc tcttctttaa gcttgtcgta agcaataatc aattcaggca ttttgcttag 2654821 tacggattga ccggcttcaa cttcgccctc cagctgctga taaacagatt gaatattttc 2654881 gtcaatgagc tgcaggattg cggacgcttc atcaatatcc agttcagtca tcaggacatg 2654941 ttccgctcgt ttcagctggt ttgacagatt ttctaattcc ttatcaagct ggatatgctc 2655001 aagcttgtac cctttttctt tcatttcgcc atagccatcc ttgagctttg caatctgtcc 2655061 gggcaccgtc tgtttacagt cagctaacag cttcggcaca tcatctatgt atgactgaag 2655121 ccgttcaaga ttgcggtcct gctcaagcag tacttttcgt gcagtaatat agtttccgcc 2655181 ttctgtttct tcttcaaatt gtttgatgcc gctccaaatt tcgtccagat ccttttcaag 2655241 gctgtcataa agctccccgt aaaggtggct gtaagccagc aggttttttc gagatttcga 2655301 atagcgctcc ctcacctgtt caatctcttc acggctcttt tcctcacttg tgacaagatc 2655361 gctgatttcc cgaagaatct tttcaatgct tgattcagcc gctgtcagca ggtcgtcgat 2655421 atgaacgagc acttgattgg cctttttaaa ccggtatttg tctgcatttt cctcggcatc 2655481 ataaaggagc tcttcaactt tcggcatgtg ggctgtgaca atctcatccc attcttcacg 2655541 ccacttctca aagaactctt ctgtctgacc cgtcattttt aaatgtttta ttttagacat 2655601 ttcttccacg atcgaccgat tcagaatttc aatcttccac gattccagcc ggtcgatttc 2655661 ggcgtagatt tttttcctga aaaagtagcc tgccgcaaac agcgcaagca gtacaattaa 2655721 taatccaatg acaaactcca taatgagccc ccttgctgtt taccttaatc tgtcagggtg 2655781 ttttatttat tcagaaagat ttcaggatat gtattgagaa aaactgtcgt tttcattgtt 2655841 attatgatac catgtaacaa acattttttg accagaaatc aaaaactttt tgtgcaaaat 2655901 cggcaggatt tgactatttt ttcatggggt gacatcaatg caaaagcgag acggacatat 2655961 tcacacacca ttttgccctc acggctccaa tgacacactc agacaatatg cagaagaagc 2656021 cttaaaaaaa gggttcgaat cgattacttt taccgaacac gccccattgc cgccatcttt 2656081 taccgatccc acgccgctga aagacagcgc gatggcgcaa gcttctttgg aacgctatat 2656141 tcatgaaatt tccggattaa aaaaagaata tcgcggacag cttagcatac ggacagggct 2656201 tgaagtcgat tatatcgctg aatttgaaga cgaaattaca ttattcctag acacatacgg 2656261 gccatattta gatgacagca tcttatccgt tcattttttg cgcacagact cttcctatct 2656321 atgccttgat tatgacgagc ataccttcaa agagctgatt tcagcctgcg gaagcattga 2656381 agcggtatat gaacaatatt accggagtat ctattcttcc attgtagcat ctctcggcgt 2656441 ttataagcca aaaagagtcg gtcacatcac actcgtccaa aaattcatca agctgtttcc 2656501 atacagcatg tcagagcata ttcgcggcct cgtttctctg tgcctgaatg ccattgaaga 2656561 aaacggaatg gagctcgact tcaatacttc cggcttaaga aaaacttacg ctggcggtat 2656621 ttatatcgag gattggatgc tgaatgaagc gaagcaaaag aagatcccgc ttgtgtttgg 2656681 gtctgatgcc catcaagcgg gagatgtcgg atatgcgtat gaggcgtttt tggaacggtg 2656741 ctagttggtg agcgccacgt ctcctgtccg gaagacgctt ctgatccaaa tcttgatttc 2656801 ttcaaaatac attttataaa aatacggctc gtgcggctgc atgtagagta cttctgaaat 2656861 atattgaggc tggagatagg gcatcatcaa gagagatttt aattggagaa taaaatgagg 2656921 cagcggcagc gttaaatatt cacgctgttt ttctccttcc tcaatgatca gctggaagat 2656981 atacttttcc ttcattagat atgtcgacat aatttccctg attaatgtgg agtcaattgt 2657041 gacttcccgg tagacaaaac gagttaattg acgatgatta tgctgatagg ataaaatatc 2657101 gaaaaccaat tgaagaagct gttcctgcgt gctttgagta gagatattgc ttgccgctgt 2657161 ttcaagcgtt ttgctgtagc cttcgtaaaa ctctgaaact aagtgttcca tcaagcctcc 2657221 tttgccttta aaatagtagg agatgtgcgc aacatttaca tcagctgact ttgcgatttc 2657281 acggacagac gtgccagaaa atcctttttg gttaaaaagc atgacagcag attcaataat 2657341 tttgtctttg gtgcttactt tcatacggct cactccttcc tcttgatact attcaagcag 2657401 aaagccgctg ttcctgtaag aacttatcga caaatgccgg cagaaaagcc ggaactttgt 2657461 tttatattat agaaaaagtg agggttttcc atgttccatg tcgaaaaaca atctggagat 2657521 aaagaaaaag actatcagct tctgctaaaa cagctcgaag ccatgaccga agacgaaaca 2657581 gaccaaatag ctaactatgc aaatgcctca gcactgctgt atcattcgct gcctgaagtc 2657641 aactgggcgg gtttctattt tgccaaagaa gaggatggac agcttgtgtt aggtccgttc 2657701 caaggcctgc cggcatgtgt tcggattcct ttcggcagag gggtttgcgg cacagcgtac 2657761 gcaaacggaa aagtggaacg tattgaggat gtaaacgcgt ttccgggaca tatcgcctgc 2657821 gatgcagcgt ctcaatcaga aattgtgctt ccgattcgtg tagacggaaa aattgtcggc 2657881 gtcttggaca tcgacagccc agtgaaaaac cgtttcgacg aaattgatga aaaatactta 2657941 actcaatttg ccgaaacgct agaaaaagcg ttagcgcagt aatataaaag cccaaaactg 2658001 atatcgtttt gggctttttt tattttattg agtcatgaat catcaagcgg tttttcccgc 2658061 tccgtttcgc gctgtagagc gcttcatctg cctcatgcac aagctctttc agcgactttt 2658121 ttgtttctgt cgtccagcag gagataccgc aggaaatggt tacctcgggt ttcgtatttt 2658181 ttctgaccgc gtaaaccagt cgctcggtaa tccgtttccc cactgcaacc ggcacatttg 2658241 gcaaataaat cgccagctcc tctcctcccc agcgggcacc gacatcatgc tttcggatgt 2658301 tgcttttaat cactgaagcg acttgaatta aaatctcgtc cccagtctga tggccgtacg 2658361 tatcatttac atttttaaaa ttatcaatat caacaagaat aaaaacaccc ttttgatgga 2658421 ttttcatgct gtattgaatt ttttcatcta aatacgctcg tgaatacagt tcagtcagct 2658481 gatctgtttt cacgagatgc tcaaggcggt cgcgaagcat tgaattggtt acagccagtg 2658541 tcgcgtgatg aatcagcgcc tgaaacagct tgtacatttc aaatgtaaaa gcgtacagct 2658601 cctgtttcaa taaaaccgca aagcctaaaa gccggtcgtt ttgaatcatc ggagcagcca 2658661 tcagcgagcc gtaccccgcc ttcccaaaaa cagactggcc attcccgatg aaaacccctt 2658721 tttcaccttc atacagcttt tctttcagct cattataaaa atctgacggc ttcgcttctt 2658781 taaaaaatgc tgtgctgcct gggagcaatg ttaggttttc aaaatggtct atatgaaaaa 2658841 atcccacttc ttctgcctga aacgattctg ccattctcac agccagatca ttcattgtat 2658901 cagtcaatgt cagccgctga ttcaggcgtc gtgatgtttc attaatcaat tccaaatttg 2658961 cgatgcttgc tttggattgt tcgtagagct gggcattttc aaacgctttt cccgcggcgt 2659021 ttgctaacag cgacatttca tcaaggcagg catcagtaag aaagctgtca cccgttcctt 2659081 cagccttcaa caccccgtat gtgccctgct gtcctttgat cggaatatag gcgacagatt 2659141 catttttccg caaaatgtct ccggacaaat acactttgag cgcaaaggaa tcggattttt 2659201 ccccttccat atacagctct tttgcaggaa tccctaaaca ttggtcttga tcgtgcgata 2659261 taaataaaga aaactcaaaa agagaaaatg tgcttgtcaa gctttctaaa agctgcttca 2659321 gcacatctgt ctgatcaagc agtgaatgga acagctctgt cattttgtat atcttttttt 2659381 ggtagatcgt tttgttatag agtctttcct gtttcatcga ctggtttaaa aatgaagcaa 2659441 ccacgtccgg aagcccttca ggaatctctt catcctgcct gcacgcaaga tggaaacgcc 2659501 tgccggagcc gtcctcaatc agataacatg aagcgtttat ttttgaagcg gaaaaacgcg 2659561 cttcaccatc tgccagtttt gtcacaaagt ctgatggtga cggtgtaagc gaaacacaaa 2659621 gggttgaaaa ataggtttga atagccgaag tcagccatat gaaagagtcg gtgaatgtga 2659681 ctttttcaga tttggttaat aaaaaatcga gcatatgata atgaaaggcg gataattgat 2659741 ctttagtttg ttctaccatg tttttatcac ctaaaagttt accactaatt tttgtttatt 2659801 atatcataaa cggtgaagca ataatggagg aatggttgac ttcaaaacaa ataaattata 2659861 taatgacctt tgtgtgaaat attgcagcct ttttgttcag cttctatgtt ttcattttgt 2659921 tccttatcaa taaggtgtat cgtgtaactc tctgctgctg gagcgaggat acatgaaaac 2659981 aaaatgtgca tggtcgaata gagcagacgg tttttatttt ccacaaaaat aaaaccaaag 2660041 gaggagtcac attatggctc gctatacagg tccatcttgg aaactgtccc gccgtctagg 2660101 aatctctctt agcggtacag gaaaagaatt agaaaaacgc ccttacgctc caggtccaca 2660161 cggcccagga caacgtaaaa aattatcaga atacggtttg caattgcaag aaaagcaaaa 2660221 gcttcgtcac atgtacggtg taaacgaacg tcaattccgc actttgtttg acaaagctgg 2660281 caaactagct ggtaaacacg gtgaaaactt catgattctt ttagattctc gtcttgataa 2660341 cgttgtgtac aagctaggtt tagcacgtac tcgccgtcaa gctcgccaat tggttaacca 2660401 cggtcacatt cttgtagacg gaagccgcgt tgacatcccg tcttacctag tgaaacctgg 2660461 tcaaacaatc ggtgttcgcg aaaaatcaag aaacctttct atcatcaaag aatctgttga 2660521 agtgaacaac ttcgttcctg aataccttac tttcgacgct gaaaagcttg aaggtacttt 2660581 cactcgtctt cctgagcgtt ctgaacttgc tccggaaatt aacgaagcgc ttatcgttga 2660641 gttctactct cgttaatcgt tttaaaaacc cctgccgcta tgcggtcggg gtttttttat 2660701 cggctttcgc ctcttgctgg ccaacactat cttgcgcctg ctgctcccaa tgatcccgct 2660761 gcagccgttc ttttgcaatc gtacacatga gattcacgct ttagcgctcc tttcatttaa 2660821 aaggtggtga ttggtcgtgt ttgccctatc taatatactc ttttcctttc attcctatgc 2660881 ggtaaacaaa aagatccttt gccttcagtg gcaaaggatc tttttcttat ttatacgtca 2660941 caaggaagta ttttttcttc ccgcggcgca gaacagtaaa ttggttttcg atgcggtctt 2661001 cacctgatag ggtataattt atttccgtct ggcgttcacc gttaatgtaa acagctccgt 2661061 tttggatgtc ttcacgcgct tggcgtttag aaggagataa tttagattgc accaacacat 2661121 ctacaagtga aagctcttgg gtgctgtcaa cttccataga aggaacatct ttaaagccta 2661181 cttttacgtc ttgagcagaa agctctttaa tattgccgct gaacagcgct tgggagatgt 2661241 tgatggcttg ctccagcgcc tcgcgtccgt gaacaagtga tgtcacttct tctgccaggc 2661301 gtttttgcgc ttcacgtttt tctggcgccg tttctgtttt ttcagcgtat gcttcaattt 2661361 cctcttttga aaggaacgtg aagtatttca agtatttgac aacgtcacgg tcgtctgtgt 2661421 tgatccagaa ttgatagaat tcatatggcg atgttttttc tttatcaagc cagatcgcgc 2661481 cgccttccgt ttttccgaac ttcgtgccgt ctgcttttgt gacaagcgga atcgttaggc 2661541 caaacgcttt tgctccttct tcttctgatt ttctgatcag ttcaagaccc gctgtgatgt 2661601 tgccccactg atcgcttccg ccgatttgca gtttacagtt tttgtctctg taaagattta 2661661 agaaatcata agattgaaga atcatgtagc tgaattccgt gtacgagatg ccggattcaa 2661721 ttcttgagct gaccgtatct tttgccagca tgtaattgat gccgaaattt ttaccaacgt 2661781 cacgaaggaa atcgatcaca ttcattttgc cgatccagtc aaagttgttc gcgatgacag 2661841 ctgggttttc tgctgcttca aaatctagaa atctggacag ctggtttttg attttttggg 2661901 accattcgga tacgatgtca gcagtgttta atgtacgctc tgcttttttt ccgcttggat 2661961 caccgatgag gcccgtcgcg ccgcccacaa gcgcaatcgg atgatgccct gcaagctgaa 2662021 aacggcgaag tgttaaaata ggcagcaggt gtccgatatg caagctgtct gctgtagggt 2662081 caaagcctga gtacaagcgg attttttctt cattcagctg tttatttaac ccttcttcat 2662141 ctgtcatttg ctgaatcaat ccgcggaagg ataagtcttc aagtaagtta gtcataagat 2662201 aaagctcctt ttttaattaa aataaaaaac gccccttcgt ttacacgaag ggacgattga 2662261 ttatcgcggt accaccctac taataagaga atgcaaacat tcgtcttatc actttgcctg 2662321 ataacggatc aggtccgttc tttcactact gaaagcctgg ccggctttgt ttgcaaaagc 2662381 ggttcatgag tgtattcgat atatccgtct gtgctgattt tcaccggcca tcagctctct 2662441 ggaacgtaag gatattctac ttgtctcaat ctttaccttt tcatatgaag ctatatcatt 2662501 tttaacataa ataaaatcct gtgtcaacgc cgccttttaa tcctccattg ttgacagatc 2662561 tccagccggc agattaagct cccatgcctt cagcacgcgc ctcatgatct ttccgcttct 2662621 ggttttcgga agcttatctt taaattcgat ctcacgcgga gccgcatggg ctgcaagacc 2662681 ctgctttaca aataggcgga tctcttcttt cagtttatca gacggctcaa atccttccct 2662741 gagtgcaata aaggctttaa tgatttctcc acgcaccggg tcaggctttc cgataacgcc 2662801 tgcttctgca atagccggat gttcgacaag cttgctttcc acttcaaatg ggccgacgcg 2662861 ctcaccggag gtcatgatga cgtcatcaac tctgccttgg aaccaaaagt atccctcttc 2662921 atccatgtaa gcagaatccc cagacacata ccagccgccc ggcatgaaat acgattcata 2662981 cttttcaggg ttattccaaa tggtatgcat catggaaggc cagccctttt tgatggcgag 2663041 attgcccatt cggtacggcg gtagctcgtt gccttgattg tcaacgatcg ctgcctccac 2663101 tcctggaatc ggcttaccca ttgaacccgg tttaatatcc atgcaaggat agttgcagat 2663161 gagctgactg cccgtttcgg tcatccacca ggtatcatgg attcgtttgt taaaaacttt 2663221 atgtccccat ctgatgactt ccggatttag cggctcaccg acactgagca catgccggag 2663281 tgaagttaga tcatatttcg cagccatttc atctcccgct cccatcagca tccgaaaagc 2663341 tgtcggcgcg ctgtaccaga cattgacgcc aagctgttca atcgttccat accagctttc 2663401 cgggctgaaa cgtccgccga cgatgacatt tgtcgctccg ttcagccacg gtgcaaaaat 2663461 gccgtatacc gtacctgtca cccagcctgg atcagccgtg caccaataaa tgtcttcttc 2663521 ctttaaatca aggacccact ttcctgtttg atattgctga atcatcgctt catggacatg 2663581 caacacgccc tttggcgtac cagtggaacc tgatgtatag tgaagcagaa agccgtcttt 2663641 tttatccatc cattcgatat ccaatcttgt gctttcctgt ttcgctgctt catcataatt 2663701 gatgatattc gtgccgctct cagcctctcc cccgactacg aagacatgct gcaagtgagg 2663761 cagtttgtct accggtattc tctccagcag ctcaggcgtt gtgacaacaa cctttgcctc 2663821 actgttttca agccggtctt tcaccgctcc ctccataaat gcttcgaaca gcggcccggc 2663881 gatggcgcca attttgattg cgccaagcat aataaaataa agctcgggtg atctcggcat 2663941 aaaaataaaa acgcggtccc ctttttccac atttccatac cgtctcagca cattcccggc 2664001 tctgtttgat tcttccttca tttctttaaa tgtgtatttt tcatcccttt ttgcgtcttt 2664061 ataataaagc gctactttgt tttttcgaaa cgattcggca tggcggtcaa tcgcttcata 2664121 cgccgcattc agtttccctg tctcatgcca agagaaatgt ttctctgcct cggcccaatc 2664181 aaaatgccgg tacgtttctt catagttttt taagttatga tccccctcta ttgctggtaa 2664241 cgctttcaag ttcatgccca aacatccccc tttgctgaag ttgtcacaat tattatagta 2664301 tatattcata ttcttctcaa tttttaaaat ataaaccatg ttgaaaacgc tttataattt 2664361 ggtattctta aagaaggcat gtatttttga taagaattga tgggacggtg aattagtgga 2664421 acatcataaa acataccatt cagcaaacat caaaacagca accggctctt tactgataga 2664481 agggcctgtc tctccagagg atttggcagg ttatgagttt cataaagatt taaccgcatt 2664541 tcgcccgcct cgcgagcagc atgaagcgct agtcgacatt gcaggccttc ccgaagggcg 2664601 cattattatt gccagagacg gccgaaccat tgtcggctat gtcacgtatt tatatcctga 2664661 cccgctcgaa agatggtctg aaggaaatat ggaggatttg attgagctcg gagccatcga 2664721 agtagcgccg gactatcggg gatgcgctgt cggaaagacg ctcctgaccg tcagcatgat 2664781 ggatgaacaa atggaaaact acattgtgat gacgacagaa tattactggc attgggattt 2664841 aaaagggatg aaaaaagatg tgtgggaata cagaaagatc atggaaaaga tgatgaatgc 2664901 aggcggattg gtctggtttg caacggatga gccggagatc agctcccacc ctgcaaactg 2664961 tctgatggcc cgcattggaa aaaacgtcag ccaagaatca attgagcaat ttgacaggct 2665021 ccgtttttat catcgttata tgtattaact gacactgaca aaggggaaaa aataatgatt 2665081 gttgagcaaa tcatgaaaag agatgtcatt acattaacga agacggatac gcttgaaaca 2665141 gcaatatgca aactgaagga attccatatc aggcatctgc ctgttgtaga tgaagaacga 2665201 cacgtgatcg gcatgattac agacagggac atgaaacagg ccagcccgag tatttttgaa 2665261 gaaaacaaac gaagcctatt tctcacacga agcgtagatt caattatgaa aaaggatgtt 2665321 gtctgcgccc acccgttaga ttttgtcgaa gaaatatcag ccgtgttcta cgagcatggc 2665381 atcggctgcc taccagtggt acaccatcaa aaattaatag gcattttaac aaaaaccgat 2665441 ttgctgcgga cgtttgtcaa attgacaggc gctgaccagc cgggctcgca aattgagata 2665501 aaagtaaacg acatcaccaa aagcctcgct gagatcagca gtctttgcca agaccttcaa 2665561 gtgaaaatat taagcgtgct tgtttatccg catgacgatc ccggtgtaaa agtgcttgtc 2665621 ttccgtgtaa aaacgatgaa tccgctgccg tttttgcagg cattacaaag aaatggacac 2665681 cacgtcgtat ggccgtcaga gcaaagggat ctgctatgag agacagtgta tttatctatt 2665741 ctccatccta ccaaacctat atgtttcatc aggagcatcc ctttaatcag cagcgggttc 2665801 tgttaacata tgatttgctt aagacgatca atgcctttga tgatggagac attgtcaccc 2665861 ccagactcgc ttcagaagag gagctttccc ttgtccacac ggacgattac attcaggccg 2665921 taaagcttgc gggcgccgga aagctccccg ctgaagaagg agaaagctac gggctcggca 2665981 ctgaagacac acccgtcttt gccggcatgc acgaagcggc atcactcttg gtcggcggca 2666041 ctttaacggc cgcagactgg gtcatgtcag gacaagccct gcatgcggca aaccttggcg 2666101 gagggcttca tcacggcttt cgcgggagag catcaggatt ctgcatatac aacgacagcg 2666161 ctgtggctat tcaatatatc cagaaaaaat atagcgccag agtgctttat attgatacgg 2666221 acgcccacca cggggacggt gtgcaattta cattttacga taatcctgac gtatgcacgc 2666281 tgtccattca tgaaacagga aggtatttat tccctggaac cggtcagatc caagaaaaag 2666341 gaagcggaaa aggatatggc tattccttta atattccgct tgacgctttt acagaggatg 2666401 attcttttct tgaggcttac cggacagcag cttcagaagt cgccgcgtat ttcgagcccg 2666461 atgtcattat cagccaaaac ggcgccgatg cccattacta cgacccgctg acgcatttat 2666521 cagcaacaat caatatatac gaagaaatcc cccgtcttgc acacactttg gctcatcaat 2666581 attgcggagg gaaatggatt gcagtcggag gcggcggata tgatatttgg cgtgtcgtgc 2666641 cccgcgcctg ggccagaata tggcttgaaa tgaagggaat tgacccgggt cacgagatcc 2666701 cgccggaatg gattgttaaa tggcaaaaac aatgccccgt ggcccttccg tcgagctgga 2666761 gcgatccggc tgatttatat cctccgattc cccgcaagcc tgaaattaca gaaaaaaatg 2666821 cccaaactgt cagcaaagca ttatatgcga tacgttctga acagcaaaga acaaagtaaa 2666881 aaacgacctt tacgaagagg tcgtttttga ttttttaatc actatttcca cacgccgatt 2666941 ttccttcatg tgttcatttg tcttgttatc ctttactggc tttgtatccg cataaccgac 2667001 agcaataaag cgcttggagg gaagcttctc tttagacgtg aagtattgaa tcactccact 2667061 tgcccgtgct gctgatagct cccagttcga cgggtatcgg tatgtcgaaa tgtttcggct 2667121 gtctgtatgt ccctcaacct gaatgtcatt tggaattgtt tgaagaagaa cggcaatttg 2667181 gtgaagaagt gtttcggcat ttttcagcac ctttgcctca cctgtatcaa acagcacagc 2667241 ctcctgaaga acgagcacga caccgcgttc atcccgtttg gctgtcattt gggccttcaa 2667301 atgattgtct tttatatatg tatttacttt cttgagaagc tgatcctgct gatcctcttg 2667361 cttcttcgta tcagatgggg atgtattctt tttttctatg gatgtttggt ccggctgaag 2667421 cccgttgcct tccttctgga tcgagtccac tgccgctttg aatttttgca gatcgatttg 2667481 ggacatcgaa aagagtaaaa taaagaacac aaggatcaag gtgatcagat ctgtaaaggt 2667541 taccatccag ctggatgaag attgactgtt ttttccgctt ccattccttc tttcaaaacg 2667601 ttctcttcta agcttcatgt acagatccct tttttgtttt tacttgtttt ggctgcttct 2667661 gccattcttc ccgtgagctg aaaacgacca gctggctttc aaggttgcgc gggttttttc 2667721 cggattgaac accgataatc ccttccacca ttacctgctt gatgaaaatt tcactttctg 2667781 ttttctcttc aagcttagcc gcgatcgggt tgaagaccat atttgccagt aatgaaccat 2667841 ataaagtcgt cagaagcgca atggccatgt ttggtccgag catatgcggg tcgtttaagt 2667901 ttttgagcat cagcacaagc ccgacgagtg ttccgatcat tccccatgcc ggagcgaatt 2667961 ctcccgcttt ttcaaaaact cgccgccctt ttcggtgccg ttcctccatt gctgcgattt 2668021 ctgaatccat gacgagccga atcgtttctt catcccagcc gtcaatcgct aaaagcagcc 2668081 cttttttcaa gaatggatct ttgatttccc gagcctgatc atccaatgat aaaagcccgt 2668141 gttttcgcgc gtgatcggaa agggaaacaa aggttttcac aagatctttc acattgtctt 2668201 cctggcggat gaatgcctgc tttaacacag agggcgcttt tttcagctca cttggcggaa 2668261 aactgataaa aacagcggcg caaagtcccc ctgttacgat gaagaaagag gtcagatcaa 2668321 gaaaagagcg gaaaccgctt actcccgatc ctgaaataat cccgataaca ataataatcg 2668381 ttcctaacac aaatccaaca ggtgtaagat aatcaaaacg tttcatcatt tctccccatg 2668441 aaaaaagcaa gaattcacca taaaggtgaa gcttgctctt tgtttttctt atgacttggt 2668501 tgactttcta agctctatac ggtgcggcag ttcgacgata tgctcttcaa ccggctcttt 2668561 attcatgagc ttcgtcagca gtctcatcgc aacggcgccg atatcatatg tcggctgaac 2668621 aactgttgaa agctgaggac gaaccatgag gcttaatctt gtattatcaa aaccgataat 2668681 gtcgagatcc tccggaatgg ataagccctg atcctgagcg gcatggataa tgccgagtgc 2668741 catttcatca gttgcagaaa gaatggctgt cggtttttta tccaggctca tcagatgctg 2668801 cagtgcttcg agtccggaat catatgtgta atccccttca gctacaaatt gttcattaaa 2668861 cggaaggttc gcttcttcaa gcgcacgttt gtagccttgg agttttttcg aacggttgat 2668921 cggttctgcc attggtccgg aaacgaacgc gatgtctgta tgtcctttat caaccaaaag 2668981 cttcacggca tcataaatcg cctgttcgta atcgatagcg actgacggtg tttcctcctg 2669041 ctcttctaca gaagcggcaa gtacaatcgg cactggagaa cgcttaaatt ccgccacatg 2669101 ctcgtccgta atgtttccgc ccataaacac gatgccgtcc acttgtttgc cgagcattgt 2669161 gtttaacaag tgcagctctt tctccatgtt ttggtcagag ttgctcaaaa taatattgta 2669221 tttatacatt gtcgcgatat cttcaattcc gcgcgcaagc tctgaataga aaatgcttga 2669281 gatatcggga atgatgacac ctacagttgt tgttttttta cttgccagcc ctcttgccac 2669341 cgcgtttgga cggtaaccga gacgttcaat ggcttccaag acttttttcc tcgttgtcgg 2669401 ttttacattc gggttgccgt tcacgacacg ggaaacggtt gccatgctta cattagcttc 2669461 tctcgctaca tcgtagatcg taatattgct catcctaaaa ccactccttt tactggatac 2669521 acttatcctt atctatagca taaacacttt atgtagagaa atgtcataat gtccgaattt 2669581 atgtcgttta tgatttgtaa gcgtaagtca gtagtgtaca ttatttttca ttattcatca 2669641 aatttaatta cttctcatga aattatacac gtttttatag atgatgaaaa cgtatacttg 2669701 gtttttataa ctaaataaac gagaaagcat aaaaaaaggc cgcaggcgcg gccttttgga 2669761 ttgttcaatt aagcgttgac tttcaccatt ggcttcagtt cattcagcca tttttcgaat 2669821 tcaggaatcg ccatttgctg agcagagtca gaaagtgcga ctgacggatc agggtgaacc 2669881 tcagccatta cgccatcagc accgatcgct aaagcggctt tagctgtcgg aagcaagagg 2669941 tcacggcggc ctgttgaatg cgtaacatca acaaagactg gcaaatgcgt ttcttgtttc 2670001 aaaatcggca cagctgaaat atccagcgtg tttctcgttg ctgtttcata tgttctgatt 2670061 ccgcgctcac aaaggataat ttggtcattt ccttgtgaca tgatgtattc agcagcattg 2670121 atgaattcag agatcgttgc agcaagaccg cgcttcagaa gcactggctt tttcacggcg 2670181 ccggccgctt tcagcaattc gaagttttgc atgttgcgcg ctccgatttg aatgacatca 2670241 atgtagtcca gcgcttcttc gatatgagcc ggagttacga tttcactgat aaccgccaga 2670301 tcaaattcat ccgctacacg ttttaaaatt tgaaggcctt caacaccaag cccttggaaa 2670361 tcgtatgggc tcgtacgagg cttaaaggct ccaccgcgca aaattttaat cccttgtttt 2670421 ttcgcagctg cagcgacttc agctacctgc tcatagctct ctaccgcaca tgggccgaca 2670481 atgaatcttt gctggccgtc tccgattttt tcgcctttga tatcaacaat tgtatcttca 2670541 ggttttttct tgcgggagac aagcagcgct ttgctgtgat cttcttcctg aagctctaaa 2670601 ccggctttga atatctcttt aaaaatgtgc tggatggttg aattttcgaa cggcccgtca 2670661 ttgttttcaa tgatattgtt taacattgtg cgttctctga cagggtcaaa tcggttgaca 2670721 ccctgtgctt ccttcgcttt accgatctct tttacaacat tgccgcgttc gttgattaat 2670781 tttaaaattt gtaggtttaa ttcgtctgct ttctgcctta aaagctctaa ctctgtgttg 2670841 ctcatttttt tcatcctttc cctgcacatt cattttttat tttgtagtta tcatgcatct 2670901 tactataagt aattccaaat ggaaatactg aaatacaaaa aattttataa aaactctact 2670961 ttattaccca aacgctttta agtgataaag taatctatga agctatccta catgatgtga 2671021 gggcaatgtt caagggtttt ttacaaaaaa aagcgccaga tgatatctgg acgctttttt 2671081 ctatgacaaa tgctgctcaa tagcggcttc tgtaatttgt gaatgtgagg tatgccattt 2671141 cacttcaccg ttctggatga tgaatatctg agggctttca tgcttgaccc catatgtttc 2671201 tgcaatgaaa ttggacagcg gccgggcttc ttgtacttga agatagtaag ccggcacatc 2671261 ctcatgctga tttgcaaagg catcaaactc atgaaatgct gcctggctga tcgggcatgt 2671321 ggtgctgtgt ttcaagaaga cgaaaacgcc ttcctgttct gcaatccgtt taaattcttc 2671381 ctcagattga ataagctgtt tagccatgac tcaagctctt ccttccctgc tcagcgattc 2671441 aactgctcag cctgtttttg tgcatctttc agttcgtctt ttacatcttc tttcgtctgg 2671501 aggacttgat cttttgtttc atcagctgcc tgcatcgctt cttccctcat atcttgcatt 2671561 gcagtcgatg aatccgtttt gtcagatttg gaacggtctc tcaaatcctt taccttgttc 2671621 atgatctgtc cagactgatc cgctacaagc tgtgtgatgt tggaagtttt gtcttttgcg 2671681 atgctgacat attgcgtgcc tttttccttc gcatctgccg tcattttatc agttttgtcc 2671741 cgtaaggcaa cagcctggct gccgagatcg tcgcgaagtt ctttgcctga tttaggcgct 2671801 agaaaaagag ctgtagtggc accgatgatt cccccgatta aagttccgat taaaaaatct 2671861 ttactattaa ttccatcttt gctcatcatt attcctcctc ttagtatttt tttctcttac 2671921 agggctgatt ttttcttttg cttccatttc tcccaaattt ccattgctgc ttgactccaa 2671981 gtgacaactt gattgatctt atcttgattc tctctaactg atgccgatac agaccctgcc 2672041 gcttgtttca tggatgtatt gaactgctgt acagaagctc ccactccttg aacagcatga 2672101 acgaccgtgt tcagcttttc tgatttttcc tgaatatctt cagccaggcg gttggtctta 2672161 tgtaaaagct cggctgtttc agttgtgatg cccttcattt gtccctccag cccttcaaga 2672221 gtggatgcga cgttttttag tgtcagctgc agtgacttca atgttttaga caagtagatc 2672281 actaatacga gaaatgcaac tgcgatgagt gcaacgctca aataaagaat aataatcatc 2672341 tcaaacctcc ttgctgcagg atatactgct gtttacccgt tttcttcaat cataaacatg 2672401 tgtactgggc tgtatacata ctattctccg ttatgtaaga aaatccttta ataagctttc 2672461 ccatcagata aataaaaagc agtgagatca ctgcttttta ttatgccatg acgttttcgt 2672521 aggctctcat atatttttgg atatctcctg ctcccatgaa gatgagaacg gctttatcat 2672581 gagcttttaa aacagatgtg tcatcttctt caatcagctt ggcattatga atttttccct 2672641 ggagatcacc gatcgtcagc tttccggcat tctcacgggc tgagccgaaa atatcgcata 2672701 aatacacaca gtcggcgccg ctcaggcttt ctgcaaattc gtcaaggaac tgctgcgtcc 2672761 gggtaaatgt atgaggctgg aataccgcga caatttcccg atcaggatac ttctgtcttg 2672821 ccgcctcgat tgtcactttt atttctgtcg gatgatgggc atagtcatca atcagcactt 2672881 gatccccaag ctgcttctca ttgaatctgc gtttgacgcc cccaaaggat ttgagagcat 2672941 gcttaatgat gctggaatca atttcttcat aatggcataa cgcaatgacc gccaatgagt 2673001 ttaatacatt gtggtggccg tacgcaggaa tataaaacgt atcatagaac gtattgcgga 2673061 caaagacatc aaaagttgtc ccttccgtgc tttttacgat gtttctggct tgaaaatcat 2673121 tttcttcccc cgtgccataa tacacaaccg ggacgttcgc atggattttc ggcagatgct 2673181 catcgtctcc gcaggcaata atgcctttgt tgacttgaag agccatctct tggaaagcgt 2673241 caaatacatc gtcaatgctt gagaagtaat cagggtgatc aaaatcaata ttcgtcataa 2673301 tcgcataatc tggctgatag cttaagaaat ggcggcggta ttcgcacgct tcaaacacaa 2673361 agtattcgct gttttcattt ccctggcctg ttccgtctcc gattaagaaa gacgtcggtt 2673421 ttgcgttttg gatcacgtga gccagcagac ccgtagtcga cgttttgccg tgtgcgcccg 2673481 taacggcaac actcgtgaat tttttcatgt agtcgcctaa aaacttatga taacgtatca 2673541 ccggaattcc ctcagacatc gctttttcta tttcaggatg cgtgtctggg aatgcgtttc 2673601 cggcgatgac tgtcatgccg ggtttaatat tttccgcgct aaaaggaaga atcgtaatat 2673661 ttcttttttc aagcgctgtt tgcgtaaaaa taaatttttc gatatccgat ccttggacag 2673721 tatatccatt atcatgaagt atttgggcaa gcggactcat accggtccct tttattccaa 2673781 caaaatgata aacagtcata attgtacctc caacaaacgt ctatctgttc cccagtatat 2673841 gacgctcatt tcaatttgcg accgcggcgg ctgaaaagcc tcccttagcg gcgtatttta 2673901 tatgttttgt tatgtttagt atcaggttat ttctttccga ttaaacccag atatcaagat 2673961 ttgtctatgc acagctgctg taaagcggca tagctgttaa atgctctaaa cactatcata 2674021 ccatgtttgg tgtgaaaatg aacccatatt attcgtttat taaatcactt gctgtgatca 2674081 gcacctctcg aggcttgctt ccttttgcct cagagatcat gccttccgct tccatcatgt 2674141 cgatcagcct tgccgcacga ttgtaaccga ttctgaatct tctttgcagg cttgaagtgc 2674201 tcgcactgtt ttgctctaca acaaactcac acgcttcgta aaacagttcg tcctcttctt 2674261 tcagggcaga tccttgtctt acgagctctt cttgttcaaa taaataggtc ggcggcattt 2674321 ggcttctgac gtgggaaacg acgcggtcga tttcccggtc tgacacaaag ttaccttgca 2674381 gacgaaccgg ttttcccgag ccgttttcca aaaagagcat atcccctttt ccgagaagct 2674441 tttctgcacc ggctatatca ataattgttc gggaatcaac ctggcttgag acagaaaagg 2674501 cgattctcgt tgggatattc gccttaatca gacctgtaat gacatcgact gacggacgct 2674561 gagttgcgac gagaagatgg ataccgcacg ctctggcttt ttgggcgatc cgcgcaatgc 2674621 tttcttccac atcgtttgga gccaccatca tcaaatctgc aagctcatca ataatgacaa 2674681 ctaaatacgg cagcttttca cccatttggt gttcagcggt taattgatta aagcggtcaa 2674741 tgtcgcggac acctgaatgg gcaaaaagct catagcggcg ctccatttcc tcaacgaccc 2674801 atttcaaagc agccgtagcc gctttagcat cagtaatgac cgggctgacg aggtgaggaa 2674861 ttttattgta aggggccagc tctaccattt tcggatcaat cagcagcacc tttacctcac 2674921 tcgggtcagc tttataaagc aggcttacta atattgtatt gatgcatacg ctttttccgg 2674981 agcctgtagc gccggcaatc aagccatgcg gcattttctt caagtcgata acaacaggat 2675041 ttcccgaaat atctaatccc agcgcagctg tgagcggtga cttgcttgtc ctgaaagctg 2675101 agctgcgaat catttggcgc aaatcaacca ccttgctcgt gcggttcggc acttcaattc 2675161 cgatcgtgtt tttccccgga atcggcgctt caatccgaat atctttagct gagagactga 2675221 gtttaatatc atcggacaag ttggtgattt tattcacctt tacacccggt tcaggatgca 2675281 cttcaaatct cgtgacagac ggaccctggg ttacatggac cacattggcg cggacattga 2675341 aatttttcaa ggtcaaatca agaagctgac gctgttcttc gatccacgca gtatcatctt 2675401 gaacctgcgc tggcgggaca tcaagcagtg caacattcgg aaatacatag ctgccgcggc 2675461 gctcctctgc tttttgctgt ttatgcgtat ctcttttcag catcatcaca ttaaaaggaa 2675521 cggatggccc tttttgagaa gatgcgcttt gttcagtcct tttctcctgt acaccaggcc 2675581 tttttttcgg ctcttctgaa gcttcgcgag gtttgtctgc gcgaatttcc tgccggtttt 2675641 caagagttgc agtagacgat ttggaaccct gctccatgtg ttcagttttc tcaagctctg 2675701 tatggctgtc tggctgaaca tctatcttcg tttcctgagc ctctcccagg gtgtcataat 2675761 gattatttat tatgctttct gatggctctt ctgattcttt tgccacagtt tctgcttgag 2675821 ccagagcctc tgatgaatac tcatgatcag taaataaagg ctcttcctga cgaatgtcca 2675881 tttgttcttc ttgaacgaac ggggactcag caccttctgc cgcgttttca tgatgattgt 2675941 atactgggct gtctgacggc tcttttgctt tttcatcctc agatactgcc tctgtctgag 2676001 attcaggagc tgtttgctct tcatcaagtt cagcggagaa aacaggctct tcaaatttct 2676061 ctggctgctg ctccctttgt tcttcctcag ccgttgcagg ctcttcgcgg cctacttcac 2676121 tgtctgaaag cccttcagcc gccgtatctg tgagcatctc aggcggtgtt tgctcttcgg 2676181 cttgttcagc tgggaagaaa ggctcctctt tttccggctg ttgaacgcct gactcaaatg 2676241 gcactttgtt acctgacggc tcggctggcc gtttcgccag cgcctcatca tgctccgtat 2676301 cctttctgtt taaaacgcca gaaggctgtt tttcaaattg ggtatccggg aagaaaggac 2676361 tttctatttt ggaatgcgcc tgtgtgtctg aagcaggata gccgcgttca cgttcgatct 2676421 cttctgacag cagtgttacc ttctctttta ccgatttatc cggttcgttc aatgtttcag 2676481 aaggcttttt cggcacatcc tttttaacag atggtttttg attgaatcca tagacaggcg 2676541 aagggatatt tgtcggttta aacggtttct tcgccggctc tgctgcttga tatgtatgct 2676601 gctcttcttc atttctggga cgctctctgt aaggtgcagc acttggacga ggcgcggatt 2676661 tcggttcgtc cgatggtgtg cggcgccttc tcaggtcatg atttttgtat ccgtcaggca 2676721 cgactggaaa acggaatttg ccttttggat attcataata tattttagga tcttccaatc 2676781 tttttaattg tccttcagga tgatgtactt cttgttgctg cggaatttga gcgggttttg 2676841 tctcccgttc agcatcctct tcgctttcgc ctaaaaacaa atcaaaaaat ttatgaagcc 2676901 aactcataat ttatctctaa ctcccttata gttttctggg acggttttta gtataccact 2676961 gctggtcggc ccagaaaaga ttaagctatc agcagaaaca aagccgctaa acaagggctt 2677021 agcggctttt cacatgattc gttttttttg gcggatttat gggagtctaa aactgaaatg 2677081 cgtctcccgc ctcatagtct ccttctaaca caaggattcc tttttcagca ggggcatccg 2677141 gcaaatcaag ctctttcgct gagcagatca tcccgcttga cggaacgcca cgaagctctg 2677201 catccttaat gacaagtccg ctaggcatca cagcaccgac tttggcaacg acaacttttt 2677261 ggccttggtc aacgttaggc gcgccgcaga cgatctgaag cgtttcttct cctacgttga 2677321 ctttacatac gcttaattta tccgcattcg gatgtttttc ttttgattct acataaccca 2677381 caacaaactt cggagataaa tcaacgacta atgtttcttc aacgccgttt ctgtttaaaa 2677441 tctcattcac atcttgcacg aatgtttctg agagcgcaac agggccgttt tcatcaatgg 2677501 tcaagtaaga agacgcattg aaaatgttga agcccgttgt ttcttttgtt tcgttattga 2677561 aaattttgac gacgtcgccg tgtttttcat agcctaattg ttcgcgtgtc acatcttgaa 2677621 gagagatcag gagcgtgtct cccacacctt ctttattata aaaagcgttc ataagtaaaa 2677681 atcctttcta atcctttttc ggacggcttt tcgccaggat aaacaccggt tccagctttc 2677741 cttcattgta caaaaatgat agggcggtaa tcgggacggt gccgcctgca aagaagctca 2677801 tcgacatttg tcctagaata tcataccccg attcattccg gatgtcagca agaatcaaaa 2677861 cgtcctgatg aggaacagag atcgccagct caccttctgc atgctgctta tactcattta 2677921 agatcgcttc gttcaaaatc cggcttgcgt cgtatccgtc gtttgccctg aagaaataaa 2677981 agtaattgcc ggcaaccgta tcctctttga caaccgtcgg cagggaacgg agattaaatg 2678041 cggccgtctc tctgatccgc tcttttgtcc agttttcttt ctcaagcatg cgctggtcaa 2678101 ttaaacggta ggttttcccg agatctagcg cgtaataaat tcttgtctct gcggtatgat 2678161 cgtcataaat gagcgggata tcttcgctgg acttgtccgg gaaggaagtc gagcggatga 2678221 ccggataaat gcgagtttct ttcccggtca tttcctgagc cttcccttcc attgccgtca 2678281 tcgcttcgga gacatagtac acgatctcat caatggcttc gtcttttttc agttcccatt 2678341 ttgcaataat cggcggcaaa tcgagtgtaa tccctttttt agtcgtttga tcctcaacac 2678401 ggagggtgtc tttttctctg tcaaacagaa aggagcgatt ctcgtgctga aggcgctgct 2678461 tcagtatatc tgacagcttc cttgaggtca ttttcaaacc gatgtcctcc tttacgcttt 2678521 agcgagagag tctgttaaaa actgttcaat ttcttctttt gttttgcggt ctttgctcac 2678581 aaaacgattt acttcttttc cttcattaaa caccacaaag cttgggattc cgtaaatttc 2678641 ccactctgca catgtatcaa tgaatttgtc acggtctacg tagtagtagg tgaattcagg 2678701 gaaattcgct tccagttcag gcaggaaagg ctctacaaaa cggcaatccg ggcaccaatc 2678761 ggccgaaaac ataaatacag accaatcatc ctttaccgct ttttccagct cttgagttga 2678821 ttcaattttt ttcatttcat atccctccag ttgtttatgt tcttacatgt tttttatcga 2678881 tactcgtcca tttggatcat accaaactgc ttgaggcaaa accacttata tgcaacgaat 2678941 gaatatgtaa gattggcttt cccattatca ttatcatatt ttatttgcat tatcaagctc 2679001 gtttcgttta acatcgtgta catgagggtg aaatttacag atggatatac ataaggaggg 2679061 atttttatta tggagtttat cgtctattta gcaggagaaa tccacagcaa ttggcgcgag 2679121 gaaattaaag aaaaaacaaa atcactgaag ctcccgatta cgtttgttgg cccgatggag 2679181 aatcatgacc gctcagacaa tattggtgaa gaaattatgg gcgtacagcc aaatgccgtt 2679241 ttaaaggatg acaaagcctc tgacatcaac aacttcagaa ccgccgtcct gatgaataaa 2679301 gcagactttg tgatcgccct gtttggcgaa aagtacaaac agtggaacac ggcaatggat 2679361 gcatcatatg cgatcgcaaa aggaaaaccc ctgattatca tccggccgga atcgctccac 2679421 catcctttaa aagagctttc caataaagcg aatattacgg ttgaaaccgt taaccaagcc 2679481 attaaggccc tttcctatct atttgaaaca gaataagaaa aaagcttgtc gatccgggct 2679541 tactgctcgt tcaacaagct tttatgaaac ctacatattt tctttaatcg catccactgt 2679601 ctgcttatcg caggctgtta caagtttgat gagcatttct ttagcagcag cataatcatc 2679661 aatatgaatg atagtagcgt ttgtatgaat atagcgggaa catattccga taaccgctga 2679721 cggcacaccg ctgttcgaaa tatgaacctt gcctgcgtct gttcccccgc cggatacaaa 2679781 atattgatat ggaatatcat gcgtttcagc catatcaaga acgaattccc tcattccgcg 2679841 atgcatgact gtcgttctgt caagaatgcg cagcaaaaag ccttttccaa gctggccgaa 2679901 ttcatttttg tctccgctca tatcgtttgc cgggctggcg tcaagggcga aaaacaagtc 2679961 cggtttaatc atatgagaag ccgtctgcgc gccccttagc cctacttctt cctgaaccgt 2680021 tgcacccgca tagagtgtat tcggaagctc tttaccgtgt aattccttca gaagttcaat 2680081 gcttaagccg catccatatc tgttatccca tgcttttgat aaaattttct tttcattcgc 2680141 catcgtcgta aacggacaaa caggcacgat ctgctgtccc ggtctaatgc cgattttgat 2680201 ggcgtcttcc ttatcatccg ctccaatgtc gatcatcatg tttttgatat ccatcggtcg 2680261 gtttcgctgc gcatctgtca ataaatgcgg cggtatgctt gaaatcacac ccggaaccgg 2680321 cccgttatct gtttgaattt caacccgctg cgcaagcaaa acttggctcc accagcctcc 2680381 gagcgtctgg aatctgagca gcccgttgtc tgtaatggat gtcaccatga agccgacttc 2680441 gtccatgtgc ccggctacca taattctcgg tgcgtcctct gcgcctcgtc tgactccgaa 2680501 aacacttccc agtctgtcct gaacgatgtc atctgcatat ttggctagct cctgcttcat 2680561 aaaagcacga acctgatgct cattgcccgg cgcgccggga agctgcgtca gtgtttggaa 2680621 aagcgctttc gtttcttgat tcatgttttc ccctcatttc tatgtagtcc ttttatttta 2680681 ttagaaacaa tgaagttttc caagcactct gacccaatct gctcgatcag ccgcgtattg 2680741 cttaacagga tttggctgtt tctgtataat gaaaagtacg atcaaccagg aggtgcttta 2680801 ttttgaaatt gcgtcatctt cttttaggag caggacttgg aatttgtacg gctgtcgttg 2680861 tgagacaata tgtgatgaag ccttatattt cttcagaaaa agcgcttcga attgtaaaat 2680921 ctgcttttaa gcagcggggc ccgattgacg gatcatggat ttacacccag ccggagccct 2680981 acaatattaa cggagaaacg gtacaggtat acaaaaccgg cattacacga tcagctttcg 2681041 gagaattaga acagtatgaa gtcatggtgg atgcgaaaac gggagaaatt gttgatgtca 2681101 ttgatacaat cgcctcttaa caccggacaa gcaaaaaata gaagccgctg cctatgcagc 2681161 ggctcttttt tattatatcg cgcgaatcgg tttgtatacc ggataccaca tcgcatcctg 2681221 cactgcctgt ataatgtctt caggctcttc cgtagcgacg ccttccttca ttgcggtttt 2681281 tgcaacttca acagcaacgg ttgccgaaac agtgcgcaaa tcttcaactt ttggaagcat 2681341 cggcgcccca ggcaccccga cattgaccat acctgcgatt gcccgggcac atgcttcaaa 2681401 catgccgtcg gtaattaatt ttgattttgt aacaatcgtt ccaagaccga gaccagggaa 2681461 gacaagcgcg ttgtttgcct gcccgatatg atacgtaact ccgttatatt caactggcgg 2681521 gaacgggctt cctgtcgtga tcagcgcacg gccttctgtc cattcgatta aatcctccgg 2681581 ctttgcttca gaaagagttg tcggatttga cattggcaaa atcgccggcc gtttcacatg 2681641 tgacgccatt tcttttacaa tttcttcagt gaaagcgccg gaaaccgtag atgtgccgat 2681701 caggatcgtc ggtttcgcct gccgaaccac ttcaagaaga tcaatgcctc cgccgtctcc 2681761 gttccgctga taatccttca cttcatcagc cgaacgggca tacggctttt ggaaatcaag 2681821 aagctgatcc atatcatctg ttaacagccc gttcctgtct atgcaccaga agcgcttgta 2681881 tgattcttct tcactcagtc cctcgcgcac caatgcttcc cgcagctgtt cggcaattcc 2681941 gattcctgcc gttcccgctc cgaatataac aactctgtga tctctcagcg gaactttaga 2682001 cgcttttgca caggataaga ctgcggccaa agaaacagcg ccagttcctt ggatatcatc 2682061 attgaaggta cacactttat ctttatagcg tttcaaaatg cttcgcgcgt ttttcgcccc 2682121 gaaatcctcc caatgcagca atgcattcgg aaatgtttct ctcgccagcg caacgtagtc 2682181 gtcaataaat tggtcataac gttccccgcg cactctggaa tgctggttgc cgacataaag 2682241 cgggtcgttc aagaggctct cctgatttgt ccccgcatct aaaacaacag ccagcactct 2682301 gctcggatca atgcccgcag ccgctgtata aaccgccagc ttgccaatag aaattgcgat 2682361 tcctccgacg ccccagtcac cgattcctaa aattccttcc gcatcagttg caacaattaa 2682421 atcgatcgta tcgctttgat ctttatactg tttaaaagct tctttcatac cgtccgggtc 2682481 atcgattgac agatagagcc ctcgtggttt tctgtattca tggctgtatc tctgaattgc 2682541 cgttccgact gtcggtgtgt agacaatcgg gagcatttcc cctaaatggt catttaacag 2682601 gcggtaaaac agcgtttcat tccgatcgtg cagcgccgtt aaatagacat ttttgctcaa 2682661 atcgtcaggc tgtgcggaat attgttcata cgctcttttc gcctgatcat caattgttaa 2682721 taccttgggc ggcagaaagc cttttaaacc aagttctttt ctttcttcct cagtaaaagc 2682781 aacacctttg ttcaaaaaag gaacagagag cacttcaagg cctcttaatg ttgtttgaat 2682841 gtctccttcg tttgttactc tgaattgttt caccctgcct cttcctttct gagcataata 2682901 gtactaggtt tgcattatta gccggaaaac atgcagggta aacataaaaa tatgctatcg 2682961 cttcattcgc ttaactgact ttttgatgct tccgtcctcc tcccattgaa gggcgcgata 2683021 ctcggcatca tggtaaaaaa taaaccaagc atctttttct gctgcgaacg cctgccattt 2683081 ctgcttttgc gggatagagg tcatcggata atcatcgtaa gccagcaccc atagcggatt 2683141 gcggtgggca tgtgtcggca tcagatctgc catatgtacg gcagtttcac ccgcatcctc 2683201 gcatatcagg acactgtgtc cgtcgctatg gcctccggtg tgatgcattg taataccctc 2683261 tgtgatcgtt aaggtgtctt caaaggtttt gacttggcca gctacagcct cccaattttc 2683321 tttccaatac gtatttttcg acctgatatt cggatggcgc atttcgtccc attcaacagc 2683381 tgatgtataa atcactgcat tcggaaagac agagacgagc cgttcacctt catattccgt 2683441 taaaccgcat gcatgatcaa aatgaaggtg tgtcattgcg atcacatcta tatcggcaac 2683501 cgttaatccg agtgcagcta atgagggttt cacattcgac tcttgtgtca cgccatagtt 2683561 tcgtttttgt ttatcagtca gcttgccgta cccaattccg gcgtcaatga tgatattgag 2683621 cccatccttt tgaatcaaaa tagggtctgt tcttagttca atctggtttt tttcattgac 2683681 tggatatttt ttagaccaaa gcggctttgg cacaacgccg aacatggcgc ctccgtccat 2683741 atgcgtcacg cctccgtcaa gccaggtcaa cgtgatgttt ccaattttca ttgtttccat 2683801 tttcaccccc ccctatcatc atggtagcaa acggcccata aaaaaaacag actcctgtca 2683861 gagtctgtct ttacgttctc cattcaacct cagcccgata gatcggctgg ccgagtgcag 2683921 agaatttttc ttcatattct gtcataatat tgccttccag attgctgtta tgcaaatcga 2683981 gactgacgta tgtcagcagg aggccgtact cagagaagct cttcaaagag tactcaaata 2684041 aacctcggtt gtccgtttta aaatgaatcg atccgccttt gcccattact tcttcatatt 2684101 ttttgaggaa gtgggaatat gtcaggcggc gtttttcatg ccgtttcttc ggccaaggat 2684161 cagaaaagtt caagtagacc cgtttcactt cccccggctc aaacacatcc gtcagcgtgt 2684221 ccgcatctat attcagaagc tttacattct gcgcttcgct gtcttttact ttttggacgg 2684281 ctgtcacgat gacgctttta aataactcaa taccaatata attgatgtcg ggattttgtt 2684341 tggccatacc agaaataaat tggccttttc ctgtaccaac ctcgatatgg atcggattgt 2684401 cgttgccaaa cactgtgttc catttccctt tataatcagc aggattgctg atggcaatat 2684461 ctgcgttttc agccaaaaag tcatcagccc aaggcttgtg gcgcattctc atatgattga 2684521 cacctctatc tattatttcg actaacaaca taccatgaat taaaaagacc cgcaagctcg 2684581 tttttccagt gtatctctct taaggccgag cgcataaaaa aagagggtcc cgtctgctgg 2684641 aacactcctt tcccatgtat aaaaacgctc tgttttgaac aatttaaccc gtatgatact 2684701 gaagggatgt gtaccgttat gggtttacat tatgagcatc aagttcattt attgaaggat 2684761 atattgactg accatcaatt ggactgctgc ggaacagtcg cagagtacga gcagcttgag 2684821 cgtgtgatta aatcactgat ggcaaacacc gagcttgatt caaatttcaa aaacgtgctt 2684881 gaagatgttt accgctacag ccaatcagga atatcgtcca aatccatcga ctcacacata 2684941 caagagcatc agaacagcct gtctcaatgg gtagagcaaa tggattcgta ttcctgatta 2685001 atcaacaatt cgtttcatga ggatatgcag ctcttccatt gcatcatgaa attccttatc 2685061 attgcctttt gctttatgcc aggcaatgaa agtaattgtt tcagataaca cataccaagc 2685121 cattcgcaac cgaaggcttt ctgtcagctc tatgccgtac atgctcagcc agctctccca 2685181 agctggcttt tcgacgtagt ggtacagcaa aggcccgagg tccatcgccg gatcagcgat 2685241 catggcgccg tcccagtcaa ttaaatacag ctggttgtct tcagacaata gccagttatt 2685301 atgattgaca tcacaatggc aaacgacttt ctcaccgaaa tgcacttcat gcaggtgttc 2685361 ttccaaatac ttgatccctt cttgaatcag cggcgaagat tgctgcacag caaatacagc 2685421 ctgcttcagc tgagacaaaa gagcccccgg gttcagcggt tcttttccaa gtctcttcag 2685481 catgtccagc aaggcttttg atgtgtgtat tttacgaagc aattcagcaa cgggccgtcc 2685541 gctcatgtct ttaggcttca gctctctgcc ggtcatccag tgctgggccg taatgacgtc 2685601 cccattttcc atccgttttg tccaaaccag cttcggaaca atgccttcgg cggataaaac 2685661 agctaaaaaa ggtgagctat tacgttttaa aaaaagctgc tgcccgttat gtttcgcata 2685721 atatgcatct cctgtagctc ctccggcggg gaagatctcc caatcgctac ctagtaattg 2685781 tcccaaccag ttcatatcaa tgttcaaccc atcatttctt aaaatatttt agaattaagg 2685841 ctaatcgttt ctagtctatc cagcgaatgc ctttttcgta cgaatcgtat aaaaataaaa 2685901 aagacagcta ttgagagtct catatgctaa tcaatagccg tcctttaaat tttagcgcta 2685961 tagcacaaac ttcgtcaagc aaaactctta agatctgatg ctaaatataa gataaccgtt 2686021 ccgatgccgt ttactgcaac cgttttcttg atttctgttg ggtcttcctg aaatcctgat 2686081 ggatcacata aaagccgata aggtatgtcg tttggcagcc tccactcgac ggagtctgga 2686141 ctcgcgtgat ggataacaat gatatctttc cattcgtcaa cctcgtcaag atcataaagc 2686201 ctgtatgcga taaggtgttc ttttagcgtc aagcattcaa gatggcgctg gatgtctgca 2686261 gcggacctaa gacggaatgc aggatgcgct tttctcagcg agatcagcct gcggatatag 2686321 tgaacatctt ctttgaatgt ttcacggcga tcccagtcga gctggttgat gctgtcactg 2686381 gattgatagc tgttttccac tccctgcttc gtccggaaaa attcctggcc gctgtgaata 2686441 aacggcaccc cttgggcaag caaaataatc gcggctgcaa gcctttgcct gcttcgcttt 2686501 cggctgtcat tttcttgagg aagcgcaaag ctcattttat cccaaaaggt gtgattgtcg 2686561 tgtgattcga cataattgat ggactggctt ggttccggaa caatcggtgc taatgccttc 2686621 catccggaag acccggcaat tccatgcatc acagcttgtg ctgattcacc gttgccgagc 2686681 gcaaaccctg ttgccttaag gtgaaaggtg ttccctttta cagcgtcacg aaacatatca 2686741 ttaaaaaagc cgatgcccgg cattcttggc gcgttcgcca aagcagcttt ctgttcatgc 2686801 ggcagcggtg tagccaggtc ccacccttct ccaaaaagca ggattccggg ctttgcctta 2686861 gttgctttct ctttcatata aagcacggtg tcaatatcta aaatcccgag gagatcaaag 2686921 cggaagccgt caacattgta ttcttcaagc caatagacca cgcaatccgc aatgaatttt 2686981 cttgccatcc ttctttctga tgcaatatca ttgccaacgc cggtgccgtt tgatggcatc 2687041 ccacattcgt cgtgccggaa aaaataaccg ggcactgtct tttcaaaggg ggaattctcc 2687101 ctcttataca catggttaaa aacaacatcc agaatgactc gcagaccgtg ctgatgcagg 2687161 gtattgatca tttgtttcag ctctgttttt ctcgtttgag gatcatgagg atttgaggca 2687221 tagcttccct ccggggcaaa gaaatgaagc gggttatatc cccaattgta tgcatcaagc 2687281 ggcttctctt catcaactcc ggcaaaatca ttcaccggca gaagctccac atgtgtcaca 2687341 ccaagctctt ttacatacgc taatcccgaa gaactgccat ttgcggtttg tgtatcagtt 2687401 tccgtcagcg ctaagtattt tcccttgttt atcatgccgc tgttttcatg gatggagaag 2687461 tcgcgaagat gcgtctcata gatgacggca tccacagggt gtgagaatgg tttaagagga 2687521 gcagtccatt tcatttgatc cgggcgcaag acgacgccct tctctccatt tacagtcaca 2687581 gccttggcat actggtcaac tgtttccatc cattctgaat tgttgcagat gcaaaacaaa 2687641 tactcatatc cgtgaaggtc acctgtgacc gtgacggcat agacgccttt ttccaagcga 2687701 gtcatttgga atgtgcgccc gcttttattg gggtgtgaaa gcttgacagc agctgaggtt 2687761 gcagcaggcg cccatacttt aaatacggta tgatccgcgg tataaacggc gcccagctct 2687821 ccgtcataat aaaattcgtc atcaaacgct gccgtccgga tgaccgcgcc aatttggaga 2687881 tccgttttgt ggccgctgga tgctctgacg caatggattt ttccaaatgt cacaggatgg 2687941 tcggatacgc agacgtactt gtattttgct tcaagggagt attcctccct gacagccaga 2688001 ggaaaatctg ttatttctgt ctcaagccga aacggcggtg tcatgatttc cttttgttca 2688061 gcaggaatca gaacagtaat gatattcatg tcatcgacat acgcttcgaa gctgcggcgg 2688121 atgctgacca tcggaagctc tctcctccaa acacgtttat gttttgattc ttaggggtga 2688181 aggactagat gccagacgaa acggggtagt gcccatgatt tctccgtcag catggaacgg 2688241 gattttgtcc ttcgtgtaaa atgtaatgtc cttcgcttta aacatcgtaa cgccatccat 2688301 ctttgtatgt tttccaaatg ccatgagaca taaaagccaa tattttttca aaaacggctg 2688361 gttttcaacg attacgatat caaatgtctt ctcgcgcgga tttgctaggg gcgccgcctt 2688421 catgcctccc ccgtaaaacg gatggttgga tacaacggca aaccagacat catgaaattc 2688481 gcgcgtctcg tcttccgtcg tacaagctaa tgtaaacggc ttaaaggttg ccgaagcgtg 2688541 caaatgagaa agcggataca caagaaatcg aaggcggaga aaaagaaaaa cccgtctcaa 2688601 cggaaattcc atcgcctttt tattgacata tgcgtcaaac ccgatcccga tatgattcat 2688661 aaaataaaga atctgtgatt tatcctgaag gaaattgacg ctccctaaat gaaaggttct 2688721 tgttaacggg cgctttacct tcttgatttc ctgtatcaga tcgatttttt taatagagaa 2688781 ccctcgcgaa aaatcattat acgcgcccgc cggcacaaag ctcagctcaa tatcgtcaac 2688841 atctttcagc ccgttgacaa cttcatgcat ggttccgtct ccgccaatga cgatcaggcg 2688901 cttcagctta tattcctgta tcgttgaaat ctgtctggcg agcacctcgg cgtgtcccgg 2688961 atgttcagtt aaaaatgaac ggtgctcaac ctttcgtttg atcaattctt tttgaatgga 2689021 cttccaaaca cgcaggccgt ttcgatgtcc tgctgtcgga ttaataataa aaaaccaatg 2689081 gctcatcttt ctcacctgct tatgttatga gaaaaccgct caaatcgttc tcttttactc 2689141 cagccactcc tgtctgcgat aggagtcaga catgcagtaa gacaatagag cctttgcagc 2689201 ctttacctga tgatgtttga tcggagcagt gtttttcttc tgccgctcaa tccattcttc 2689261 cgcgctccgc ttatccgcta tttctaagcc gtatggcggc tccgggtaat cgatgtacga 2689321 cgttctgctc agaagcaatt ttcgaaccgg aatctcagcc tgtttttcct ttacgatctt 2689381 tgacacaacc gagtccgtac gaaacaggct aagccctgga tttaacactg atgcagtctg 2689441 agaggctgtt ttcttgtccc aaaaacgatt tttagaccct atgtagacac tgtcttcctc 2689501 agcctctaaa aaagaaacgc aataaatttc cagaggagaa ataatcacaa tgcttaattc 2689561 aaccgccgcc tgctgaattt tcagcacagg cttatacata ataaaataag aatcaggcag 2689621 ctgctgggtc agataacgca aaatgcggtc ctgcttcact tggtttgaga gttgagatat 2689681 ttctgaaaga gtagagcttg cccatttgag ctgaaaatca tataaatgcc ttttataaaa 2689741 agaagcaagc gccaccctgc tcttcgggag ccttacatga atatcttctt cgtcctcaaa 2689801 ccattggtgt ctctcttctt gtatatcggc ttttatctct tcttttcttc ttttcaatga 2689861 aaattttttt cgtttctgca ccggttccgg ttcttcagca ctggcttgcc tttcttcatg 2689921 ctggcgctcc gctgcttcta ctagtgaaag ccagcgctct tttttcaaac gtacaaactg 2689981 gttgatataa tggtacggat caagctcata tctcgatata taatcatgaa ttttgatgat 2690041 ttgtgccatg tttgtttctc cactccgcaa tgaattaaga taattgaaat ttgaatattt 2690101 cctcgtattt tggtgattgg ttcaagtgta tttgaaagag cgaaaatcgt tcagccatca 2690161 tcgaaacctc gccgctttca aacggaacat gagctggaaa tccatcttcg cctgtccatt 2690221 ttcttgccag cgtcatatga ggatgatacg gtcttttttc cacttgaaag ccggcctgaa 2690281 gtacagcctg cttcgtatgt tcccgcagtc tatcaagcgt tttgtttttc tttggctcca 2690341 gatgtaaaac gcgcggcttt ctgcggtcgc cgaatacatc tatcttgcca aacttaattg 2690401 aaaatggatc aatttctgaa gcaatctctg ctagcgaacc ttcaagcttc tttatttgtg 2690461 tctcatccgc cgctccgaga aaaattaacg tgatatgata gtcaagcggg tgcacccatt 2690521 tttgaaacgt caatatcggt tcgtttttcg cagcctggta gatcggattt gcaattccct 2690581 caggtatggg aacgccgatg aaataatgag gccgtatatc tggcatccgt ctgacactcc 2690641 cttctttgac agctattatt ttatcaataa agaggctgtg cggatagagg aacagtgtat 2690701 gaaaacactc tcgcacaaac gtttattatg ttaggatatt atatgacact tgttttattc 2690761 agaaaggaat gacaatgttg aaaatcgttg caaacacagc tgatctgata ggagatacac 2690821 cgctagtgag attgaatcgg cttcagccgg aaaatgcggc acaagtctat ttaaagcttg 2690881 aatttttcaa tccgagcggc agtgtgaaag acagagccgc ttatcaaatg atcatagaag 2690941 ctgaacaaaa cggtttactc aagccgggat cagttattat agagccgaca agcggaaata 2691001 ccggcatcgg gctcgccatg aatgcggcag cacgcggata taaagcaatc ttagttatgc 2691061 ctgatacgat gacgaaggaa cggatcaacc tacttaaagc ttacggtgca gaggttgtat 2691121 taactcccgg agaggaaaga atgccgggca gcatcaaaaa agcgaaggag cttgccgaac 2691181 aaattccgaa cagctatatt ccaatgcagt tcgataacac tgctaatcct gatgcgcacc 2691241 gaaaaacaac agcgcctgaa atcgcccggg caatagagga aatcggaaaa ccgctcggcg 2691301 cttttgtagc ctcctctgga acgggcggaa ccattaccgg aacaggtgag gcgctcaaag 2691361 agctttttcc ggatatcacg gttcatgttg ttgagccagc gggttcgcct gtattatccg 2691421 gcggaaaacc tggcgcgcat aaacttgtag gaacgagccc aggctttata ccgccgattt 2691481 taaatgaaga cgtttatgat gaaattatca aaatctctga tgaagacgcg tatacgacga 2691541 caagacggct tgctgctgaa gaaggaattc ttgtcggtcc ttcatcaggc gctgcctgct 2691601 tcgcggcaat cgaaacagcg aaacgcctct ctcctgacaa agttgtggtc tgcatgacag 2691661 ctgatacagg agaacggtac ttatcaactg atttatggtc atttatttaa aaaaaggact 2691721 ggcttcagca gaagccggtc cttttatttt gcaagctcgt aaatggcctg agcatataac 2691781 gctgtcgatc tcagcaggtc atcaatttcg atatattcat ccttttggtg tgcgctgtca 2691841 gggcgtccgg ggaacagcgg gccgaacgcg acaccggctt ttaaggatct cgcataagtc 2691901 cccccgccga ttgagattaa atcagctttt ttacccagct ggccttcata aaccttttgc 2691961 agggttttga ctaacggatg atctgcggac acgtgatgcg gcttgctgtc tttgaattct 2692021 cccagctcaa attcagatgc gctttcgaat gtatcgcgga tcactttgct ttctgctgtc 2692081 acaggatagc ggatattgat cccgagctcg cctccttgcc cttctttata gcgcagtgtt 2692141 ccgacattta atgtcagctc tccgctgatt tcatcctcac agtcgatgtc cagttttttt 2692201 cctcttgtat cacctgagaa cttatctgtc acaacttgca caaaccgctt tcctgcatcg 2692261 tcaagctcag tctgctggag aaattcgcac aataaaatgc cggcattgat cccattgttc 2692321 ggttccatcg catggcagga aagaccgtac atacgcaaaa tgagctgtcc gttctctatt 2692381 gcagcttccc ctttttggtc cgtcgtgcgg agcatgtctt taaatgaaga cagaatctct 2692441 tcatttttcg gcccttcaat gacagcttcc gcagcgtcgg gcaccatgtt taagcgaagg 2692501 cctgattgaa acgagacaag cactgccttt ggttcagctt gatttgggcg gtgcggaata 2692561 agtaaagaag catcgatgat ccctttttcc gcattaatga tcggaaaatc ggcgtcaggc 2692621 gcaaagccca ttgttggcat ttcttcatgc ttgaaataat gctctacgca tctccaatca 2692681 ctttcttcat ctgttccgat aatcattctg actcgcttgg acaggggcaa attcatgtct 2692741 ttcacgattt tcagcgcgta gaatgccgcc attgtcgggc ctttgtcatc aatggcgccc 2692801 cttgcataaa tccgtccgtt gcggatttca gctgaaaatg gatcactcgt ccacccatct 2692861 cccggcggca cgacgtcaac atggcaaagt acgccgataa tgtcatcgcc ctccccccat 2692921 tcaatatgac ctgcgaagcc gtcaagattt tttgttgtaa agccttcttt ttctccaagc 2692981 tccagcaatg aagtcaggct ggcatttacc ccttctccaa acggtttacc gggtccggcg 2693041 gttgtttcgt ccatgacact gttgattctc aaaaattcct gtgtatcacg aattaaatcc 2693101 tctttttttc tgatcacttc aacttcccag ttcataatga tcccctttcc gcaagaaatg 2693161 acttgcaaaa accaaataaa acgaataata ttaatggtgt tttgttaaaa cgttcgtaat 2693221 tggaggatac tatgtttcat ctaaaagagc agcaaacatc cataaagcaa gaaatcatag 2693281 cagggctgac gacctttttc acaatggtct atatcgtcgt ggtcaatccg gtcattctgg 2693341 ctaacgccgg ggttcctttc gaccaggttt tcaccgcaac gattattgcc tccattgtcg 2693401 gaacgctgtg gatggccctg gcagcaaatt atccgattgc tattgcgccc ggcatgggct 2693461 tgaacgctta tttagccttt catgtcgtaa gcgcaagcga tggcggcatc acgtacgcaa 2693521 cagctttcag cgcagtattt acagcagggg ttctcttcat tattctatcg ttaacgcctt 2693581 taagaaaaca acttatagaa gcgattccaa acaatttaaa atacgggatc acaacaggga 2693641 tcgggctgtt tattgctttt atcggtttgc gtcaagcggg aattgtggca gctgatgagt 2693701 caaacctggt cactctcggc aatctgcatt cacctggtgt tatcttaacg ctggtcggcc 2693761 ttttgatcag cgtggtcctg atggtgctga atgtaagcgg cgctttattt atcggaatgg 2693821 cagctaccgc tttgatcgcc tttttcaccg gtcagctcca tttttcaaag ggatttatgt 2693881 cgcttcctca tttgccggaa ggattgatga tctcaaatcc atttaccgct tttggcgatg 2693941 tcattcatca cggcctgtac gctgtcgtct tttcttttct attagtcacc atttttgata 2694001 cgacaggcac gatgatcgga gttgccgagc aagccgggct gatgaaaaac aacaagctgc 2694061 cgaacgtgcg aaaagcgctg cttgctgatt caaccgcgac gacagtagga gctgttttcg 2694121 gcacaagtcc gacgactgca tttatcgagt cttccgccgg tgtcgcagcc gggggaagaa 2694181 cggggcttac ggctttgact gtcgcggtga tgtttgcggc ttcaatgttt ttcagtccgc 2694241 ttgtcagcgc cttgtcaggt atagccgcca tcacctcgcc tgctttgatt atcgtcggca 2694301 gcctgatgat gggctcagtt tccaatatga actggaaaga gatggacgag gcatttcctg 2694361 cgtttctcgt cattctagcc atgcctttga cctcgagcat ttctacagga atcgcgcttg 2694421 gctttatttc gtacccaatt gtaaaagcgg cgcggggaaa atggagagag attcatccgc 2694481 tcgtcatcgt tttcgccatt ctgtttttca tccagctgtt tattttataa ggatagacca 2694541 aaaaacccaa acgtcgccgt ttgggttttt tatgtaaaca ataaagagac agcggccgct 2694601 aaaaaacaac aggcggcaaa cgcatagtgc aggatgttga tacagctttt tctggcccga 2694661 taatattcat cactttcctt atcggtgcca attaaaaaag gggcatccat gaccttgtca 2694721 aaaataagcg tcaggatata acggcaaacc cctgtgtata ccagcagcgc aatcaccttc 2694781 agccaaattg gggaaacaaa tatgagaaca gtgaaagctg acagtagcat gtacatctgc 2694841 cttgcatact cgccattcct cagcataact ttaaaaaaca actccttata gcctgtgcag 2694901 atcgttcgtc ttttaaatat cctttttgaa tttcggtata ataatggttt tcttctcatc 2694961 ctgtctttta cttttggcat tcccgcctcc tgactcatca tcatcacaag tcctgcaagg 2695021 gcaagcctgc tttttttctc ttcagtcacc tcagcttcaa aagccgtgaa cgaggctgtc 2695081 tttttcaaac tgcggataac tgagaaaaac aaaaataaaa tgccaaaaag cgcaagcaag 2695141 tgccgctcag taaaaacaat caggatagca gaaccagcaa aaagaatagc tctgacaagg 2695201 gtatcgccaa tccatctcga aatggagcgc ggctttctga tcctgtcttg ctttaaggat 2695261 aaaaagaata tatgaaggcc aaacaaataa cacaatagag cagtgctttc tgcgaatgtg 2695321 atgagaacag aatgactgat caagggaagg acaatgaaaa agagaagcag ccatttagcc 2695381 agcgtggcca gaaaagaata caaaagcgca taccgtttga gctgatagat gatttccttc 2695441 ttttgcagca aaaacacttt gtccgcttcc attaaaaatg tacgaatcga acctgtaaac 2695501 atgatcagca cacacacagc atacagccat ctccattccg ccacttcaga ccactcataa 2695561 agaaggcctc ttccgttcat caaatcaata tactgataga tgacaaaagc aatcgccggc 2695621 aaaacgatat agagagcgac tgtccagtca atgaccgcat gcaacacttt aaactgatac 2695681 ttataatagt caaacagcct tcgaaaaaag agcgtacgcc cgttcatagc cgatcacctt 2695741 gaactgcctt ataaaaacag tcaagcaatg actgcccctc taatccggtc ttgtcctgaa 2695801 catcttttaa cgtgccttgg agaaataatg aacctttctc aatcatataa aaccggtcac 2695861 agattttttc cgcggtatcg agtacatgcg tgcacataag aattccggct ccacgttctt 2695921 tttcagcctt aagcatgtcc acaaagcgtt tcgtcgatat cggatcaagg ccgataaacg 2695981 gttcatcaat cacatacata tccggcttag agagaaaggc ctggataagc attagttttt 2696041 gctgcatgcc cttcgaaaag gtgacaggca gctcatgttt gacatgatct agcgaaaacg 2696101 tctgcagcag gctttgggcc cgatgcgcaa attcactctc ttcaatgccg tgaagtgtgc 2696161 tgatcagatc caaatgctcc cacagcgtca gttcttcgta gaaggacgga tgctccggaa 2696221 tatatgcaaa tgaacagtcg ttccaggcaa tatgcccttt aaaatcttct gaaaggccga 2696281 gtatcgcctt gattgcggtg ctttttcctg cgccgttagc tccgatcagt ccaaccagtt 2696341 ccccttttct gacttccaga aaaacatcgg tgagcacttt ttttcggctt gtatacccgg 2696401 cctgttctat tgaagcttca agcaaatttg tcaaaactca ctcacctcca aaatttacta 2696461 cgaaatagaa taaaaaaagt ttctttaacc ataataatat tgagccgaaa tacatagtaa 2696521 tccaacaagg atggctgccc aacgcgaaat tggaaaaaat taataggagt tatccctaga 2696581 ttcatcactg caatatcgtg tataatgagg gcgaattatt ttaacaatta cagatgtctg 2696641 cctttgttgc tatttcgtac gcagttgata gtcgtgagtt gtggttagtc aagtccatcc 2696701 gatcttatga tagggagtgg ttttttgaaa ccttcaacaa accgtatgct aactcgaatc 2696761 aaatcagttt acatgtttat tcaagaaaaa ggtcttgtga caacacagga actggttgac 2696821 gaattcggca ttacacctag aacgattcaa agagacttaa atgtgttggc atataatgat 2696881 cttgttcata gtccaagccg tggcaagtgg gagacaacga gaaagaaagt aaagattacc 2696941 tcataaattg aaaattacat agggccgcct gagagcggtc cgatagataa cagggcgaag 2697001 aaactactga gccttgtttt tgtgtgctta taaataaaac cccgcattcg gtatgcgggg 2697061 tttttgtcat gcttgcggct catttagcaa atgaagctct tcctctgtca gctcacggta 2697121 ttctccgggt gccagagcgg gatctaggga aacgcgtccc atcgaaagcc gcttcagata 2697181 aaccacttca ttgccgactg cctttgccat ttgcttgacc tgatggtatt ttccttctgt 2697241 aattgtcaga tatataacgg tattgccact gtcgtttgtt ttgatttccg cttttgccgg 2697301 ctttgtttta tagccgccct ctatgtagac acccgtttcc aaatcggaaa tgtcttcccg 2697361 agaaatctgt gattttaaat ggacttcata cgtttttgga acatgctttt taggagaaag 2697421 gagccgatgt gcgagctggc cgtcatttgt gagcagcaaa aagccctctg tatctttatc 2697481 aagcctgccg gctggaaatg gctcaaatct catctcctcc ggcgtcagca gatcgaccac 2697541 tgtttgctgc cggctgtcct cagtcgccga cagcacgccc tgcggtttat tcatcataag 2697601 ataaatgaac tctcgataat caaccggttc cccgtatacg gtcacctcct gcgtatcagg 2697661 atcaacgtgc tcctttacat ctttggcagg tttgccgtcg atcatcacgg ctccagcctt 2697721 cacaacggct ttgacttctt ttctggaacc atacccgctg ttggcaagca gcttatcaag 2697781 tctcattccc aatctctcct ttataaaaga aagcccgcag catgcgagcc ctcagtttca 2697841 tcatatctag ttcatcagcc tgcatgtctg cctttcctaa agaaacctgg caaacggcgg 2697901 cctaaaattt tctgcaaaaa tcctaatcgg tagccgcaat acaggtagac agctccgcca 2697961 acagcggccg cgatcaccac aacaatcgca gcttgcatct ggccatcctg ataggaaata 2698021 aagaagccta atacccactg cacgattttc acggcaatac ccataatggc tgataagacc 2698081 agcatcaaaa cagttcgttt aacaagtatc ttatacgaat agcctgcatg gcgcttaatc 2698141 atgataaacc catataaaag ggaagcgata tatccaagcg ccgtcgctaa aatcgctccg 2698201 tcagcctgca tcagcttgat cagcggaaca ttcagcacaa gcttgatcac gacaccgatc 2698261 acaaggctga caaccgcaaa tttttgctta ttgatgccct gcagaatagc tgcgttgact 2698321 gtaaacaaag agaacagaat tgcgacaggc gaataccaaa gcaaaatgtt tgcccccagt 2698381 tcaggatgaa ggctctctga cccgtaaaag aacgtatacg tcggtcctga caatagagag 2698441 atcccgacaa cagccggaat aattaaaaac aggatcgtct gcatcgtttg attaatctgc 2698501 tgatttaaca gcttatagtt tccgcttgta aacgattcag taatcgttgg aattaatgtc 2698561 agtccaaaag cagttgctag ggaaaccggg atcatcacga gcttctgaac atacagggtt 2698621 agaatcgcaa gcatgtcctg gctgatggct tgatgaccgg cttcaatcat cgctttgtta 2698681 aacgtatttg tatcaatata gttatacaaa gggatggcta gtccgacaaa aacgtacgga 2698741 gcagcatagc tgaacagctc gaaaaacatt ttcttgtagc ttaggtttgc tgtcggaccc 2698801 gtattcggca tcatcgccag caggctgccc ttccgtttgt tccaataaat ataaagcacg 2698861 accagccctc cgaaggcacc gatcagcgct gcgaaggttg catagcccac agcgatgaca 2698921 aggccgccgt tgaaaacctt caaaatcaag aatgtcgcac tcaatagaaa gatgatgcgg 2698981 acaatctgtt caacgacttg ggaaacagct gtcggaccca tcatttggtg cccttgaaag 2699041 aatccgcgga caaggctcat aatcggtacg accaaaagcg ctaagctgac catgcggatg 2699101 acataaacga catgatcaat tgtcaggccg ttattatcct tgcctcccag cgatatttcc 2699161 gcaaacatcg gagccgatag atacagaatg aaaaaggcta tcattcctgt gactagcata 2699221 accgacatgc ccgccttgag cattttcctg cttgtctcat aatccccttt tgaattatat 2699281 ttggaaacaa atttagaaac agcggccgga aagcccatcg tagcaatatt caaaaataaa 2699341 gtgtattggt tgtatccgta ttgaaataat gcaccgcctg tcgccccgac cataatgctg 2699401 aagggaatta aatagaccat ccccagaatc cgcgatatat atgtaccgag cgttaataca 2699461 aacgtgcctc ttaacagttt gcttgacatg tttcttcatc accattttct acgaagattc 2699521 aacttttcta ttttaccaca actgggcatt tagacggtaa taaatacaaa agcaatcctg 2699581 tgaacattca tgtccgcggc aaaagacgtt taaggagcgg ctttctttcg ctataatagt 2699641 actgcggacg ggtgtccgca cacgaaatga aaagaaagtt gatgataaag atgaaacaat 2699701 atgacgtaat cgtaatcggc ggaggccctt caggcttgat ggctgcgatt gcagcaggag 2699761 aacagggcgc tggcgtgttg ctgatagata aaggaaataa attaggacgg aaactcgcga 2699821 tttccggggg cggccgctgc aatgtgacga accgccttcc tgtggaagaa attatcaagc 2699881 acatccccgg caacgggcgt tttttataca gcgcgttttc tgaatttaat aatgaggaca 2699941 ttatcaagtt ttttgaaaac ctcggcattc aattgaagga agaggatcac ggccggatgt 2700001 ttcctgtgac cgacaaagcc caaagtgtcg ttgacgcgct gttaaacagg ctaaagcagc 2700061 tccgcgtaac aatcagaacg aacgagaaaa ttaaatctgt tttatatgaa gatggacagg 2700121 cagcagggat tgtgacgaat aatggcgaaa tgatccatag ccaggcagtc attattgctg 2700181 tcggcggtaa aagcgtgcct cataccggaa gcacgggaga cggctatgaa tgggctgaag 2700241 ccgcgggcca taccataaca gagctgtttc cgacagaggt tcccgtcact tctggcgaac 2700301 cgttcattaa gcaaaaaaca cttcagggct tatcactaag agatgtagcc gtcagtgtgt 2700361 taaataaaaa aggcaaaccg attatcacac ataaaatgga catgctgttt acccatttcg 2700421 gcctctcagg acctgccatt ctcagatgca gccaatttgt cgtaaaagag ctgaaaaaac 2700481 agcctcaagt gccgatcaga atcgacttgt atccggatat caatgaagaa acgcttttcc 2700541 aaaagatgta taaagaactg aaggaagcac cgaaaaaaac cattaaaaac gtgctgaagc 2700601 cttggatgca ggagcgctat ctcctattcc tgctcgaaaa aaacggcatc tctccgaacg 2700661 tatcgttttc tgagctgccg aaggatcctt tcagacaatt tgtaagggac tgcaagcagt 2700721 ttactgtcct cgcaaatggc acactgtcgc ttgataaggc atttgtcacg ggaggcgggg 2700781 tatctgtaaa agaaattgac ccgaaaaaga tggcttctaa aaaaatggag gggctttatt 2700841 tttgcggtga aattctggat atccacggct acacaggcgg atacaatatt acctccgccc 2700901 ttgtcacagg caggcttgca gggctaaatg ccgggcaata cgcccgttct taatcattac 2700961 tctttaaatc tcttgccgcc aaactcacat ttgaacattc cccgcattca tgttagggtg 2701021 agacttgttt tgtttcacct gattgcgggg taattttaag agaggaatga gctgccatcg 2701081 tacgaccata ctaagcctgc gagcaagata taggcgtaca caaaaaatta gagggtgaga 2701141 aatgttgaaa catatatcta gtgtattttg gattgtgatt gcaatcacag ctgcagctgt 2701201 attatggggt gttatttctc ctgacagcct gcaaaatgtg tctcaatcgg cacaagcatt 2701261 tattaccgat tcatttggtt ggtattatct tttagttgtc tctttgtttg tcgggttttg 2701321 tctctttttg attttcagcc cgatcggaaa aatcaaactc ggaaagcctg atgaaaaacc 2701381 ggaattcggg ttattatcat ggtttgccat gctgttcagc gcaggcatgg gaatcggctt 2701441 agtattctac ggtgcggctg aaccgatcag ccattacgca attagctctc catcaggtga 2701501 aacagaaacc ccccaagcct tcagagatgc actccgctat acgtttttcc actggggttt 2701561 gcacgcttgg gccatttatg ccattgtggc attatgcatt gcctatttcc aattccgcaa 2701621 aggcgcaccc gggttaatca gcagcacact gtcaccgatt ctcggggata aagtaaacgg 2701681 accgatcgga aaggccattg actgtattgc agttttcgcc actgttgtcg gggtgtcaac 2701741 aagtcttggt cttggcgcaa cccaaattaa cggcggtttg aattacctgt tcggcattcc 2701801 gaatgcgttt atcgtccaat tggttttaat cattattgtg acagtgctct ttttactttc 2701861 tgcgtggagc ggactcggaa aaggaattaa gtatttaagc aacacaaaca tggtattggc 2701921 cggattgtta atgttgttta tgctcgttgt cgggcctaca gtgctgataa tgaactcatt 2701981 tacagattct atcggacaat acattcaaaa tatcgttcaa atgagcttca gactgacacc 2702041 gaacgatcct gaaaaacgcg aatggattaa cagctggacg attttctatt gggcatggtg 2702101 gatttcctgg tctccatttg tcggcatttt catcgcccgt gtatccagag gccggacgat 2702161 ccgcgaattt ttaatcggcg tcttggtgac accttgtatt ttgacatttc tatggttctc 2702221 cattttcggc gtatcagcca tggatctcca gcaaaaaggc gcgttcaatg tagcaaagct 2702281 gtccactgaa acgatgctgt tcggaacact tgatcactat ccgctgacaa tggtgacatc 2702341 gatccttgca ttgattctga tcgcagtatt ctttatcacg tcagctgatt cagctacatt 2702401 cgtgctgggc atgcagacgt cgtacggttc tttaaatccg gcgaattctg tgaaactcag 2702461 ctggggtatc attcagtccg ccatggcggc tgtgctccta tattccggag ggcttgccgc 2702521 tttgcagaac acagcgattc tggcagcgct gccgttttct atcgttatcc tgctgatgat 2702581 tgcctctctc tatcaatcgc tctcaaaaga aagaagagag atcaaaaaag cggagaaact 2702641 cgataaacca agaagtccaa gagtgaaaaa agcatattaa caaaaaagat ctttccgcgc 2702701 ctgcggaaag atctttttat ttgcgatata aaataagggc ggaaaaacag taaagctgct 2702761 cgccgtctgg gtcgcacgcc gccgaaaccg tatatttgat atctatcagc tgctcctccg 2702821 atatcccttt taaaaatgaa ttgatttccg tttgtaagtc tttttcatgc tcttcatcaa 2702881 ataccgctac cttcagcatt ttatccgctc tcctttctct atcaatctat tccgtttgga 2702941 acagcgttat gatagagaaa tgatgattat ctcgtttccg gataaaaagc tttccgtata 2703001 tgggatttcc tctgtggctc gccgccgtgc tgctccactt tcagcagcac ggcataaaca 2703061 atgcgcatat ggcagtagct gataaggctg acgctgaaaa aagggacaat gcccggcagg 2703121 tacgcaagca agaaaaagag agcaacagtc agcgcaagca tagtaagcgt atattgcaaa 2703181 tacgccacac tgagcaagag cgaaaatttc acatacagac gttttttcca gtcaaaatgg 2703241 acaagcagcg gaaacacata aaaaagcatg gatacgaaca aaaagccaaa tatcataatg 2703301 gcgaagcgca ggatgtgcag aaggaaatga cttggataaa ttaaggccaa atcaatataa 2703361 atgatcactc cgatgagcgc cagtacagcg ccgagcagat ttgaacgaaa aaattcaccc 2703421 ttgtattcct gccaaaacgt tttgagcacc ggaacgttgt cctgcccctg gatccacttc 2703481 cgcatgacag cgaataaagc cgcggtcgcg ggcatgatgc caaacacgcc gagaccgagc 2703541 aacgtaaaaa acagccacag caagtttgta tacgcaaatc tcataatcca ttcgcaaaaa 2703601 cgcagcatcc gtcccagtga gccatcatgt tccatggcgc cccctccttt tttgcattat 2703661 acattctgca tctgaaaaag ctctttcatg ccgatcggct tcttttcggc aaccgagcgc 2703721 cacattccct caccaaccgc gatggagtag gctccagctt cagccccggc taaaatatca 2703781 tagcggcgca gcgggtcttt ccctaaaaaa agatcctcaa gcaaaagcgg atcacctccg 2703841 ccatgccccc cttcattttt gaccacttgt atcgtctgct ttgattcaaa aagcggatag 2703901 tattcgattg tctgctcagg aaaagcaaac ggaattctgg aaggttcgtg aaattcattt 2703961 gattcaatac gtccttttgt gccgttgatc gtcagccggt agccttcata cggggccgaa 2704021 aaaataatcg agtagcttaa cagtgcgccg ccatcatatt tgactgccgc cacgtacgta 2704081 tcctcgatgt caatttcctc gtcaaaaata cacgcgtcag gcctgtatgc agtatataag 2704141 ctggactggt ctcctgcttc aagatgatca tcctttatag aagctttaga ggaacgggga 2704201 tgccaccttg aatagtagtg gcatttttct ttaacacggc acgtcccgca aaaacgcccg 2704261 tcttcttccg gcaaggggtt ccactcactg tccggcccat agtaattcaa ggcgccataa 2704321 gcaaatacct cttccggatt ttgcccgagc caccaattga cgagatcgaa gtgatgtgtt 2704381 gatttatgga cagaaagacc gccggaaaac tgtctcgacc tgttccagcg tttaaaatag 2704441 ctggcgccat gatacgtatc aatataccaa tttaaatcaa cagaagtgac cctgcctatt 2704501 tttccgtcca gaatcatttc ttttattttc cgatgaaacg ggctgtagcg atagttaaac 2704561 gcgacggtga cttttccttc gcttttggcc tccgcttcaa gcacccgatt cgcatcctgc 2704621 actgttgtca ccattggttt ttcagtaatc acatctgtat tccactgaag gctttttaca 2704681 atatatgcga catgcgtatc gtccctgcct gccacaatga cgatatcagg ctttgagacg 2704741 cgcatcatct cgtcaaaagc atcttcgcta aactcaggca cgtgggccag ctcgggaaat 2704801 ttcttcttgc aaacggcaaa acgtttcgga tcggcatcca gcaatcccgt aatctcataa 2704861 tgagttgaaa accgctccat cagtggtttg ataaacatac tgaatgctct gctgctcaat 2704921 ccgcaaaaga cgatgttctt caatatcctc acctctatcg ggcttcagtt agttgagaaa 2704981 tcagctgcag cgcttcctct gttttttcag catacacagg gataaacgcc gccatatcgc 2705041 gattcaattg aaaagaatag ccgttcagct gttttttccc tttttcgatc tgaacggcat 2705101 agatcgtttt ttctcctgtt tttttattaa cagttgtata aggagatgtt ttttcaggag 2705161 gcaatccgtt taacggctga aaattttccg gatcatcgta agcttgaaac atgtcttcag 2705221 gcacgatgaa aacatctccc tcatgggcgg taatttcagt cagcagtttt tcctgaaaag 2705281 ctggaaagat atcgaccttc ccggcattct gctcggcggc cttttttatt ttttcctgta 2705341 cgccagcctg catatcagaa aagagaatga catgcattcc gtccggcctg cttgagcatg 2705401 atgccaaaaa gagcactgag acgatcacac acaaagccgt acgtatcctt tttgtcattt 2705461 ccccgctgac ctaaaaagag gctccagctc tgtcatagct aaaataaacg cgccggctcc 2705521 gtgcagatcg tttgtgcttc tttcgcggct gacataatag tcatagaaac cggctgacgt 2705581 tccgacacat atgtctttga cgagaaacgc tccgtcttct gatgtttcgg ttttatgctg 2705641 aatcaagcct tgatacgctt ttagcagtgt tgtttcgtaa gctctgtcta gatagccttt 2705701 attgattcct tttgcgattg cgtacatgta cagacaggat cctgagcttt ccagccagtt 2705761 atcagacctg tctcccttat caacgatctg gtaccataac cccgtctctt tgtcttgata 2705821 gcgacagatg cttttaatca tgtcctgcag cgtgtttttc cacacatgac ggttcggatg 2705881 cttcttcggc agctcttcaa tcatgtcagc aagagacatg acgtaccagc cgatggaacg 2705941 tgcccaaaat tccggtgaac agcctgtctc ttcattggcc caaggcattt ttttcgcttc 2706001 atcccaggcg tgataaaaaa gtccggtttt tgcatccttc gtatgctttc tcatcaatga 2706061 ctcctgaagc acaacctgat caaacagctc cgtctcctgc ttcagattgg catatttcag 2706121 tgcaaacggc ccccccatgt ataagccgtc aagccacatt tggtaaggat aaccgtcttt 2706181 gtgccaaaaa ccgccctcag acgtccggtt cagtgttcca tataagctgc gcagcctttt 2706241 tgccgctttg acataccgtt catccttcgt ctgctcgtat aatggaaaaa gaatgagacc 2706301 tgcttgaatg gcgtccagtt catctcttct aaataataga ttgccattat catcgattaa 2706361 gagatctgca taagccttcg catactcaaa ataccgcttt tccccggttg cttcccacag 2706421 ccgcaataca ccgcataaga aaacaccctg atggtagtgc cagcggtttg caggtggcag 2706481 ctcctcgact gtgtacgtgt tcataatggt gtttgccaat gcctccgcgt acgtaagagg 2706541 cgattttaca gcgattgatt gatccattga tcccatccct ttcctaataa attccttcct 2706601 cgccaaattt cttcgccaaa cgattcgcta gcatgaccaa aatcagcccg accgccgctt 2706661 taaatacgcc gactgctgta ctgtagctga attggccctg tttcagccct gcagtataaa 2706721 catacgtatc aaaaatttcc gccacttccc tgttagtcgc atttaacagc aaatacacat 2706781 gctcgaagcc aagctccagc gtgtctccga ttttcaaaat cagcaaaacg acgataacgc 2706841 ttttaatggc gggcagcgta atatgccaca tttgccgcag ccgtcccgct ccgtccattt 2706901 tcgccgcttc atacagctgg gggtcaaccg ctgtaatggc cgccagataa atgatcgtcg 2706961 accagcccgc ttccctccag ataacctgca gaatatacag gggccggaac cattcttcgt 2707021 tcagcagaaa attgattttt tcaccgccaa aaaacacaat cagttcatta atcaagcctc 2707081 cgtctaccgt taaaagcaca aacgaaagcg atacaacaat gacccaagac ataaaatgcg 2707141 ggatataaat cagcgtctga acaaattttt taaagagagc aatccgcact tcgttcaata 2707201 gaagcgccag cagtatcggc accgggaaaa atatggccag gttcaaagca aataacacga 2707261 gcgtgttttt taacaagaga aaaaatgtag gctcagtaaa cagcctgata aaatgcttca 2707321 gccccaccca ctcactgccc aaaatgccga ggaacggctg ataatcctga aacgcaatca 2707381 caattcccca catcgggaca tacttaaaaa gcaaaaaata aatacacccc ggcaaaatca 2707441 tcaagtacaa atatttttgt tgaatcagct tgattagtaa gcgctttctt ttttcttttt 2707501 taaaaatgac tgcatcaaca gccggcgctt gcgcttctgc tgttttcatt ttttcctagc 2707561 ctcctttcac ggattcttgc attcactgta gcgcagcagg caaaagtccg tctacaatca 2707621 tatgatcaca tcctgtttta tccctttata atcaagggtt cagccggtcc acctgaaaaa 2707681 aagacaccga tattagaaaa tgattattga caatatctat caatctttgg attaattgta 2707741 ttaaggtgaa gtggatgtta tgaaatgggg ggttttatga aaagaagcca atacaagttt 2707801 tactacaaac tgatcacgtt tttctgcctg ctcagcacca ttccggttat tttggtcgga 2707861 ttattttcgt acgagcactc tcagaaaacg gctatttcca acgtttcgga ggaaaaattc 2707921 gacacactcc agcagaccca gcaaagcatc gagcatatat tgaaaaccgt cgatcactct 2707981 ttaacccact atgtgagttc gccgcctctc cttcgcacat tgtccgagcc tttgcactca 2708041 gaccaatttc aaatctataa ccaagtgaac caagagctca attatctgca aagctttgat 2708101 accgatctgt ccaacatgac gttagtcagt tatacgaaaa aatggtacat gaacaattcc 2708161 ggtttgtacc gtttgaatac agacactctt catgaagcag cctcagcgta cacgaaacaa 2708221 aaagcgagcc gctcctattg gacgcttgag gaaaacaatc atttgatttc aaccaaagaa 2708281 ggcacagcag aaaactgccg ctacaatatc aatttaatta agcagcttcc tttgaacagc 2708341 acaaatacaa agggattggc cgccgcaagc atcccgagct gttcgcttgt caaaaatatg 2708401 cccggctatt caaacgccaa caacctgttt atcatcgatg aaaaaggcct catcatcctt 2708461 cataacaata tgtctgacgt tggtgaatct cttcataacg acggctttgt ccaaaaagtg 2708521 ctggcgcaaa cggccaatag cggacagttt gaaacagtga ttgaccggat tcattataaa 2708581 gtcacctatc aaaaatctga ctataatgca tggacttatt tttctctcgt ttccctgcct 2708641 gagttaaaaa aagaagccaa atcaatcggc tggatcactt ttgcagtatg cctcattttg 2708701 ttaacgcttt cattgctgtt ctcttggctt ggctcccgcc atttttacaa gccgatcagg 2708761 gtgctttacg aatcattcgc aagacatgga gccatacaag agaaacaaca gcctcctcaa 2708821 aatgaatttg agttaattga acagagcttt aagcagctga aggacagaaa tgacgacctt 2708881 gaagaaacga tgaagcagca ggccactcat ctgcagcaat attttatggt caggcttatg 2708941 cttggaaaac tgacggatga ggaggttgat aaccgttttg aaagcctcgg cttaaagcaa 2709001 aattggcggc accttgccct gcttgtgctc caaattgaca cactgaatca tacgccttat 2709061 gagaaaaaag atatggatct gcttttgttt gccgtcaaca gcctgattga gcgcaacatc 2709121 ccgacggaca aacatcttgc ccccgccgta gttgacaaac agcaggcgac gattttgatc 2709181 aatcaaagcg ggacaaagga agaattcatg gctgagctga atgagactgc aaggatgatt 2709241 caggaaaaag cggaagctga gctgcagctg tctgtcagca tcggcatcag ccagccgttt 2709301 gatgtgctga caaaagcgaa aacagcctat gcggaaggct cagaagcgtt gaaatatcgg 2709361 ctgaaagcgg aaaacaagtc gatcatcttt tacgaagacc ttgaccagaa aaaaaccttc 2709421 aaaacccatt ttccaaagca gcttcagcat gagctgttcg atgctgtcaa agcaggagac 2709481 aaggagaaag cggataaatg cctgcacgcg attttacaag ccattttcac ccagaacacc 2709541 aacccgtatc aatttcaaat cgccatcgcc cgttttttga accatgtgat tgagctgatg 2709601 catgtgcttg ggatcgaatt gtttgagctt gaagaaaaca aaatgctgta tgaccaaatt 2709661 tttgagctga aaacgttcga ggataccgaa aactggctaa agaatgagtt tattgatccg 2709721 atgacagaca aagtgaacgc ccgcgcggat gcccagtaca aaaatatttc cgacaacatc 2709781 attcatatca tccatcatga gtttgaatcc gaattgacac tggacgaaat cgcacgcagg 2709841 ctgcattaca acccaaatta tttaagcagt attttcaaaa aagaaatggg aatttcattc 2709901 agcgagtatg tctcaagcta ccgacaccat atggcgaaaa gctggcttgc cgaaaccgac 2709961 atggcggtca aggacattgc cgaaaagctg aaatataaaa actcccaaaa cttcatcaga 2710021 tcatttaaga agctggaagg gattacaccg ggaaactacc gccagcaaaa aagaagcatg 2710081 taaaaaaccc aaaaccgctt gcgcgttttg ggtttttcca atgttatttt gcttgtttaa 2710141 acgcttcttc gtattcctga ataatttgtt ttcctccgct tgactcccat ttttccactt 2710201 ctttatcgaa ctggctttct gtgatgtctc caatcatata tttgtaggtc gcgtcatcaa 2710261 tgattttctt cagttcgtca ccccgttccg actccgatgc ggaatacagg ctttcagccg 2710321 ggtttgagac gataatcttt tcattgtcct cggtcagctc ctcgtacgcc gtccgaagcg 2710381 gatctccagt gttttttaag taggctttat caatggcaat taaagcggac agcggctgaa 2710441 tatcagtctg ccagtctttt acctggcttt ctttgcgtgt aaacgttttg tcctcacctt 2710501 tgttgtaatg aacgccgtca atgccataag tcatcaggct atagacatct tcttcggcaa 2710561 ttcggtcaaa aaacgccaag atccgtttaa gctcagcttc cgttttcaca ctcgttttcg 2710621 ggaaagcaaa cacgccgtta tggcctcctg atgcccatac ccgctctttc ccatctgggc 2710681 cttttatgcg gttgatgatc tcgagcttca tcgatttatc agaggcatgg tcgcgcagat 2710741 tgaccgcatc taccatattg ccaatataaa ttccggcttt tccttgagaa aacagctctt 2710801 gctgctgggt tttgcttgtg acgggaaaat ccttattcat atacccgtta tcacgcagct 2710861 ttttcatata gttcatcgtg tctttgtatt cctgtgtcat gaaatcaggc gtgaatttgc 2710921 cgcccgattc cttccaatct gtcggcatgc cttcatacga gccaatcgtt ttaaacgcgc 2710981 cgtaaatcaa gtcattacgg tctgccagcc cgaatgtatc atctttccca tccttgtccg 2711041 ggtcgtcctc cgtaaatgct ttggccactt cataaagctc atccaacgtt ttcggggttt 2711101 tcaaatttaa attgtccagc cagtccttcc gaatgacgat cccctgtctg gaaagcgggc 2711161 gctctctgta tatcccgtag agcttgccgt caattgtcac atttttatta atgagtttgt 2711221 tcattttgtt taagttggga taatccttga tataatcgcc gatttcccaa aacattcctg 2711281 accgaaaggc attcatgact gacgaatttt taatatcctg gatggtcacg atttgcggaa 2711341 gattgccggc tgcaagcgct gcattcagcc tgtcttcttt caccgcgtct ggaacccagg 2711401 tgatgtcgag ttctgtattt gtcagctttt caatttcttt aatcgccctg tctttcggcg 2711461 gctgctggtg atacaaaatc gccatccaag acagctttac ctttgaatct gggccagctt 2711521 tgccttcagc cgaagactga tcagttcctt tacagcccgc cagcactccg ccgagtgcca 2711581 gtacaagcac aatcaaaagc accctccatt tgtttcccat cgtacccctc cgtttcatat 2711641 ttctttatcc tttgacagat cccagcaaag ctccttttgc aaaatgcttt tgtataaacg 2711701 gatagacaag cagaacaggg atggtcgcca ccactatgac cgccatttta atggtttgct 2711761 caggcggcgg gctgcccgac cccatttcag acatatcccc ctgcataccg cttgatacaa 2711821 tgacgatttg gcgcagaagc acctgaattg gccattttgc tgaatcattt aagtacaaga 2711881 tcgctgtcat atacgtgttc caatacgtga ccgcataaaa tagtgaaatc gttgcgatcg 2711941 caggaagaga cagcggcagc acaattttaa agaatatgcc cagatcattg cacccgtcaa 2712001 ttttcgcgga ctcttccagg cttgacggga tattttgaaa gaagtttttc agaatgatca 2712061 ggttaaaggc attaatggct gtcggcaaaa taagcgccca gtaagaatcg agcaatccaa 2712121 gcgatttgac cacaaggaaa gtcggaatca tgccgccgct aaacagcatc gtaaatacga 2712181 cgagaaacat gagcggctgc cggccgatta aatcacggcg ggataacccg taagccatca 2712241 gtgacgaaag aaacatgctg accgcagtgc ctatcactgt cacaaacaca gaaacaagca 2712301 aactcttata aataatatct gttgaaaaaa tgtagcgata agcatctagc gaaaaagtgg 2712361 tcggtattaa aataaatttt ttcgacacga cttcttctac tgtggcaaag gatgctgcga 2712421 taacatgaat gaacggaagt acgcatatta aagcgaacat cagcaagaaa ccataaatca 2712481 acatatcaaa cagacggttt ttcagtgaat gtgcgatagc tcccacctcc ctttgtaagc 2712541 gttatcatat ttttggaaac cgagctcagc atgtgacgat atcgtgtcta aaatgtagca 2712601 aatctgtgat tgccatgtct ataatcattt gaacagtgtc cccggccggg cgggggctgc 2712661 cgcgaattga gaccgataac aaaagaaaaa gagcataatc ttagaaaatg attatgctcc 2712721 gttctcctcc tcgttcagaa gttcagccgt attgatttgt ggcgaaaacc caagttcatt 2712781 cacggcagat tcaatggacc atggccggcc cggattatca gagacggcgt aataagtgcc 2712841 ataccggatg ttggtctcaa tggcggcttt gaaaatcgac agcagatcgg ggtgagaaag 2712901 cagtgtcttt ttcgtccgtt ctttttcatg cagcgtatcc atttcatctg tcacgactgt 2712961 tccgattcga aggttgatta ctgatagctt attttccaaa taaaacaaat ggccgatctg 2713021 ttcagaggtc agctttaata caccgtacaa gttttttgac agcggataat cgcttgttgt 2713081 gatttcccgt cctaagagcg agcgcccgtc tttttcatat acatctgtga catgattgct 2713141 gctggcgaac acgagctttt gaatgccgag ctccgctgcc gcacggcaca gataatagct 2713201 tgccctatag aaaacatccg tcattttttc aaactcagcg atgtccataa tatcgtattt 2713261 gattttcaca gcgagtaaat tcaagatggc atcggtatct tttggaatct tcttcaacag 2713321 ctcctcataa tttgccgcgt cagcctgaat ggaagaggct ttgccatcga aatgatcttt 2713381 atcaagcaca gtcacttcat agtctgaaat aagcccttca gcaagcagtc tcccaatcac 2713441 accatttccg ccggcgatca gcactttttt cacgatgttc actccccttt tttatagatt 2713501 gcccattttc ggcggggctg acactttttt ggcactcaca ttcttaggct tattcaaaag 2713561 tcaccggcag ctcctcaagc gcccgaaatc caaaaagcgg ccgataccgc cattcaaaat 2713621 ccgcaagatt aaggctgggc attcgctgca gaagagtgtt aatcgcaatt tgcgcttcta 2713681 atcgtgccag cgaggaccct aagcaaacat gatggccatg cccgaatgaa agatgcggat 2713741 taggacttct cgtaatatcg aagacatcgg ggttcgtgaa tatgctaggg tctcgattag 2713801 ccgctcctaa caaaagatag acttgttctc cttgacggat cgtcaccccg cagatgtcaa 2713861 tatcctctga cgcaactctg gctgtcattt gcgtggggct ttcatagcgt aaacattcct 2713921 cgactgcggt accaataaga tctggatttt ctctcagttt caaaagctgt tctggatgct 2713981 gcagcagaca aaggactgaa ttgctgatga gattgaccgt tgtctcatgt ccggcgatcg 2714041 ccagcaatat gcacgtagat gccgcctcct cttccgtcag cttatccttt tctctcccct 2714101 tcaagagcat gctgatcata tcctgttgag ggtggcgttt tctcttttga atcagctctt 2714161 tgaaatatgc catagcctgc acagccataa tattgccctc tgttaatgcc tttcttgagc 2714221 gggtaaaatc aatcgtttga atgagactcg cagcccactc ctttaattgc tccctatctt 2714281 cctccggtac acctataatg ttagctatga caaaacttgc taaaggaaaa gcaaagtccg 2714341 aaatgacctc catctttttt ttaccttgca cttgatcaag caaatgatgg acagtttcaa 2714401 tgatatacgg ctgataactc tctgtcgttc tcggcgtaaa cgctccgctg gcaagcgtcc 2714461 gcaatcgtct atgatcaggc tggttctgaa acagcatcat ttgattttgc acatgtgaaa 2714521 ggtcctgata tttggttgag ctctcaggca gcggggtgcg gactttgaat ctcgcatctt 2714581 tcaaaatagc agccgtttct tcatatcctg tgacatacca gcccgggtat tttaagaaac 2714641 tccctttata gataggatga acagctcgca atgtgtcgta aaaagaatat gggtttttca 2714701 aaaactcaga agatgcagtt gacgatgcaa ttgtcacgtg attttctcct ttctgttcaa 2714761 aaataaaaac aatcgacatc ataccgattg cttttattga ttctttcagc ttttcgcact 2714821 taaactagcc ttcatttctt cgactgattc aacttcaaag cctaaatcac tcagcatttt 2714881 atgatcctcc gtctcctctt gcccggcagt tgttaagtag tctccgacaa aaatggagtt 2714941 tgcggcgtaa agccctaatg gctgcaatgt gcggagattg acctctcttc ctccggaaat 2715001 gcgaatttct tttgatggat tgataaaacg gaacagcgcc agcactttta aacaatacag 2715061 cgggtttaat tcgttgacgc cttctaacgg cgtgccatca attgcatgca aaaaattcac 2715121 aggaatggaa tccgcgtcaa gagccttcaa gcttttggcg atgtcaatga catcctgttt 2715181 cgtctccttc atcccgataa tggcgcctga acacggagac agccccgatt cttttgcgat 2715241 ttcaaccgta ttgactctgt catcgtatgt atgtgaggtt gtgatgtttg aatggtttct 2715301 ctgtgacgta ttcaaattat gattatagcg gtctactcct gcatctttga gccgcttcgc 2715361 ctgctctggc ttcaacagtc caagacatgc acaaatcttc agtccatacg tctctttaat 2715421 ttcctgaacc gcatctacga cctgatccac ttctctgtta gacggacctc tgccgcttgc 2715481 cacgatacaa tatgtgccga tattcagatc gtgcgcccgc ttcgcgcctt caagcagcgt 2715541 ttccttattc accatccggt aagactcaat cggcgctttc gaaatcgcag actgtgaaca 2715601 atagccgcag ttttccgggc agagcccgga tttcgcattc ataatcatat tgagctttac 2715661 tttttttccg taaaagtgtt ttctgatgtg aaaagccccg tgcattaata gcaaaatatc 2715721 ttcatcagga caatgtaata ttgaaagcgc ctcttcgtca gtcacttctg ctccagccag 2715781 cacccggtct gcgagttcca tccattgatt cattctcata cccccacttg attcatcagt 2715841 aatgatagat tgatatggtc ttttaccata tgtagaaccg tttctttcgt cacgttggca 2715901 agctttggcg taacccctaa aatcggcaca ccgcataagc gctcaatcat ctcaggattg 2715961 gttttttcat cttcatcagg agagtcactg attccattga tgataattcc ggcgattgga 2716021 agccccatgc tttctgcata tttgacagtt aaaaaggtat gattaatggt tccaaggcga 2716081 ggacgcgcca caataatcat gggaagctgc aacgctttta tgacatgact gaccaaatag 2716141 tcctctccca atggcacaga aataccgcct gcaccttcta cgatgaagca ttcatgtttt 2716201 tctctaatcc gcccccaatg gcttaaaacc tcttccatgg tgacagtctt tccctcaagt 2716261 ttccctgcaa cgtatggtgc aagcggcgcc ttgaaggcaa aaggcgtaat gtcttcatga 2716321 gaaagactgg tctgcgacat atctttcagc aaacttgtat cactatctgg atgatggcgc 2716381 gatatcccgc ttaaaaatgg tttatacacc ccgacatgtc tattattgtc tttcaataag 2716441 gcagcaagac cgctggatat aaccgttttc cctacttctg tatcagttcc cgtcacaaaa 2716501 aaacccctca aatgatgtgc agctcctttc cgattgaatg aaatgtttgc agcaaatgat 2716561 caatatcacc catactgtgg tcagacgtga ttgtaattcg aatccggctt tcacccggcg 2716621 caacggttgg cggccgaatg gcaggagcat aaattccctt gccctgcagt ttttcagcaa 2716681 ataggaccgt tttatgggca tcgccaatga ctacaggaat aatcggtgtg tgatctcctt 2716741 tcaccacata acccatattc ttcagactgg ttctgatcat gctgatataa gaaaataaaa 2716801 gctgtcgttt ttccctgctg gcttcaatga tgttgaaagc ctcgtgagca gccgcacagc 2716861 tggctggcgg aatagcggtt tgaaagataa atgttctggc atggttcagc aaaaagtcga 2716921 tgaagaccgc tgatcctgcc gcaaaacctc cttccgcgcc aacagctttg cttaaggtgc 2716981 cgataacaat gtcgggacaa acaccaaagt attcactcgt tccttgtccc gaatcgccca 2717041 aaactcctgt tgcgtgggca tcatcaacga ccacgaaggc atgatagcgt ttcgcaagtg 2717101 agatgatctg atcaagaggg gcgattgtgc catccatgct gaatactccg tctgttacga 2717161 taaaacggcg ctgataacgc tgtgtttcat tcagcttgtt ttcaagatca ttcatatcaa 2717221 tatgccgata aacaactgta tcagccttag aaagtcggca gccgtcgatc atacttgcat 2717281 gattgagctg gtcacttaaa atgacatctt ccttttctgg caaggatgaa aggacaccga 2717341 cattggccaa gtaaccgctc gaaaacagca gggccgcttc tgtcagttta aagctggcaa 2717401 tcttcttttc tagcttttca tgccagaccg aattgcctgt cgttaaacgt gaaccgctgc 2717461 ttcctgtccc aaattgctgc aatgctgttt gggctgcatc gatcaaacgt ctatcgcttg 2717521 cgagccctaa ataattgttt gaggaccaga ccgtttgatt ttcgccatca atattcctct 2717581 ctggaaccgg cgctccatcc attgaccgca ggttacgatg tacgccggct tctttcattc 2717641 tgtctaaccg ctcgtttaac caggaatcaa tcttcaaggc tcgtaacctc gtggatcgct 2717701 tgtttcataa tggcaaccat ttccgagagc tcttcagctg tgctggcaag aggaggaaga 2717761 aatgcaatca cgtccccaag cggtcttgtc agcattccta actctctcat ttttaaggaa 2717821 actttgtatc caatccgccg atcagccggg taaggttctt tagtttcctt tgatcgtaca 2717881 agctctgcac cgcacataaa gccaagctgc cgaatatccc caacatgagg aagagcgtgc 2717941 agatcttgaa gaagaaaatg gagcttttta cttttttccg ctacttgttc cacaatgttt 2718001 tcagattcaa ataatgccag attttcaagc gcaaccgcac agccaagctg attgcctgta 2718061 taggaatggc catggaaaaa ggtttttagg ttttcataat catcatagaa tgccttatag 2718121 atgtcttcag tggcaaacgt aacggcaatt ggcaaatagc ctcctgtaat gcctttaccg 2718181 gcagccatca gatcaggctg gacattctcg tgctcgcacg caaacatttt tcctgtacgg 2718241 ccaaagcctg tagcgacttc atcaacgatc attaagacat cgtatgttgt acatagctcg 2718301 cgcacgcctg ccaaatatcc ttccggcatc acgatcatac cggacgcgcc ttgtaccatt 2718361 gattcaatgg aaagcgcggc aatttcctca tgatgttcct caagcagctg tgcaagctct 2718421 cggaggcact gatcacggca ctcatcagga tcaccgcttt cagaacgata cacataagga 2718481 atcggggcct tgtaactctc gaacatcaac gggccgtata cgtggtgaaa aagctcaatt 2718541 gaaccgacac tgacggcgcc aatcgtatca ccgtgatacc cgtttttcat tgcgatgaat 2718601 ttttgtttct cgggcttccc gatgttcttc caatactgaa acgccatttt tagggctatt 2718661 tccatcgcct ctgcgccgct gtctgaataa aagacccgcg tgagcttttt tgggctgatg 2718721 tcgattaatg tttcggcaag ctgggttgct ggaacattgg tcatgcccaa taacgtggag 2718781 tgcgcaattt ttccgagctg tttttttatg gcgtcatcta gttctttttt gcggtgtccg 2718841 tggacattaa gccaaaccga tgaaaaaccg tcatagtatt ccttgccgtt tatgtctttg 2718901 actttgattc cagtcccgct ttcgatgatt aaggggtttt catcataatc tttcatttgg 2718961 gtaaatggca gccagaggtg ctttttactt ttttctatca aatcatgagt catgatcttc 2719021 ctcccactct attaaaatag gctgcttctc caggtcatgt atgtacgtgt ttacatcatt 2719081 ggatccatca ataaaaaaga ctcggcagcc ctcttcagtc ccgtattctt tcattgctgt 2719141 aatacgctga tagcccattt tcttacccgc aacatagcct gttatgtaat ccggatcgtc 2719201 cgaccagcat aattctgcaa cgactgccgg gtgccggctt acctttgaag cgagcgcaag 2719261 ggcctctttt attcttgaat gagctggcac gtgactgtga agcgcccatt tttcaaaatt 2719321 agcgtccggc caatccattc tggagacccg cacccctttt tcttttgttt gatccattcg 2719381 cttgcctgta tgaatatcaa acaacaccgc acccctgaca tctgaccatt cagggatttg 2719441 ttcatatgct ttttcaatca cgtctcgtga aacgccttct ttttccaata acaatcgggc 2719501 aagcttttgt ccttcttccg ggcagctcac ttcattcgta tgcacaggca atggctgaat 2719561 ggtttttatc gattcatgta cctcttcaaa ttgaatttgc ataaaatcag gttttcctct 2719621 tgaatgggat aacccttttt ctaataaagc attgactgta tgcttcatct catggaaagg 2719681 aataagccgt tctccgccgg atatatgctt tccgccgtct tcatgagatc cattcattga 2719741 agccctcatt ctgacactat aaaaagtttc ttcttgcatc atttctcgcc ctttcactga 2719801 taactgaaga acgtgtagcg cttctcacct aaattgttaa ccaattatat tcaaaggtta 2719861 acaattagaa tatattattc tctcctgttt ctgtcaatag aagaaaggat cgatttatgg 2719921 cagttggtta aaaggaaaca aaaagaccgt tttcacacaa aacggtcttt ttcgatttct 2719981 ttttacagtc acagccactt ttgcaaaaac cggacagctt catgccttat aactgctgtt 2720041 tcgaaatgtc ccgaagcaga acggaccact cggtagcaat cagcagctcc ctgtccagca 2720101 tagacagctg tcaattcttt ttcgattttg tccacgccct cagccggcgt taaccgatcg 2720161 tgtacaccaa caagactaag gtgcgggcgc ggcgcgatca ggctttggat ctccgatgcg 2720221 gaaaaatgct ttgcaagcga tgggacgtaa taataaaagc cgtgcctgtc aagattctgt 2720281 gttttgatca gcacgtgatg atccacctgg ctgcacaaat ccacacacac cttaatccgg 2720341 tcatcgagcg ccgctgtcca ccacgccatc aaacctccca tagacatgcc gatggttccg 2720401 atcctgtcag gctgaacatc agagcgtgac tgcatatagt ctaacgcact taaactgtca 2720461 taaatcatca tcccccacat cacttttccg gtgagaagca tttctttaaa tatctcgctt 2720521 tccgcttttc cccgccgatc tccaaacccc caatgatcaa tcgcaagaac gccgtatccg 2720581 agtgaagtaa gctcatcaga aaaagaaggc gttttcaaat aatccgctcc ctcaatcagc 2720641 tcactttttc ccctatcata ctggcctcca tgcgaatgct gaaacaatac ggctgggcac 2720701 ggtccttctg ttttcttcgg cttcacaaaa taagcgggcg ccttttcatg tccatttaaa 2720761 tcgagcagga gcgtttcaac gatattttct tctctttctt caatacgtaa tgtctcaaca 2720821 ctgattggcc tccgatcagg caaatcacca agcaatcgaa acagttgctt tcttctttcg 2720881 gctctcatcc catcaccctt ccttattcgc ttacttcaca tttacgagac agatctgggt 2720941 tcccctttat ttttccaaca taaatcacat catttactaa atatttagta aatattatgg 2721001 aatatttcga aaacaattat tgtaaccgct tacttttata tgataatatc aatttatcaa 2721061 aaacagatga gttaatattt tactaaatag atgagaggga tacccatggt tcgtattaaa 2721121 gatatcgcct tgaaagctaa agtttccagc gcaactgtgt ccagaatttt aaatgaagat 2721181 gagtcgcttt ctgttgcggg cgaaacgaga caaagagtca tcaacatcgc tgaagagctt 2721241 ggttatcaaa ccgttgccaa acgccgaaaa tcccgcgggc aaaaacagcg ggctcagccg 2721301 ctgatcggtg tgctgagctg tctgtcccct gatcaggaaa ggcaggaccc ttatttttct 2721361 tccattcgga aagggattga aaaggaatgc tttgaacagg aaattttcat tacaaattcg 2721421 attcatctcg gctcctttca ggaacatatc tttcgggaat tggatggtgt cattgtcatc 2721481 ggccgtgttc atgatgaagc ggttaagcat atcagcggga ggctggagca tgccgtattt 2721541 atcaatcatt caccagatcc gcaagcatac gattcgattg gcatcgattt tgaatcggct 2721601 tcacgccagg cgattgatca ccttttcgac ttaggctaca aacggttagg ctacattggc 2721661 ggacaagaaa aagagcatac gctgaaggac ggccaaagca ttcgcagaac gattgaagat 2721721 aaacgcctga ccgctttttt ggagtcagcc gccccccagc ctgagcatgt gctgatcgga 2721781 gaatacagca tgcgtgaggg ctatcgcctg atgaagaaag caatcgatca aggccatctg 2721841 ccggaagcat tctttattgc cagcgattct atggcgatcg gcgcattaaa agcgctgcag 2721901 gaagccggac tgcaagtgcc gcgggatacc gcaatcgtca gctttaacgg cattgaggaa 2721961 gctgaatttg ccagcacgcc tttaacgacg gtgaaggtat acacagagga aatgggccgg 2722021 acaggcgtaa aactgctgct tgaccgtctc aatggccgaa cgcttcctca acatgtcacc 2722081 ctgcctacaa cattaatcgt aagacaaagc tgcggatgta cagcaaagga ggtgacataa 2722141 gcaaagattc atcacgatga taaggaggaa aagatgaaac acacttttgt tttatttctc 2722201 tctcttattc tgcttgttct gcccgggtgt tcagcagaga aaagctcagc agataccgca 2722261 aaaaagacgt taaccattta ttctacaatg tcaaccgaca gtgaaagaga tacgttcaga 2722321 aaactagcgg cagcattcga aaaggaacac agtgacattc atgtcagcct tcatttccca 2722381 ggcaatgact atgaaaatat gatgcgtgtc agaatggcgg ccaatgattt gccagatcta 2722441 ttcgatacac atggctgggg gaaaatcagg tacggagaat atacagcgga tctccgggat 2722501 atgaaatgga ctcaagatct tgatcccaat ttaaacagca tcctcaaaaa taaaagcgga 2722561 aaggtgtatg cctatccaat caatcaggca aaagacggtc tggcgtataa tcgcaatatt 2722621 ttagaccgtt acggcattgc tccgccggaa accatggatg actttatcaa agcactgaga 2722681 acgattaaag aaaagagcaa gggaagcatt gttcccttct ggtttgccgg atatgacaaa 2722741 agctcattcg cccaatatta cgaccaattc gctacacctc ttctcatcac agaccctgcc 2722801 cataatgaaa aaaaacagct catcaacggc acttttcaat ggagtaaatt cacttattta 2722861 tcagaaatcc tcaaacaaat gcagaaagaa aaattgatca atatcgacgc cgtcacggca 2722921 aaaaaatcac agctcattga attaatggcc caaaacaaaa tcgcctttac aatgcaaggc 2722981 ggcacactcg gccaagacgt tgcccagatc aacccgaacg tcaaggtcgg cattatcccg 2723041 acacctgcca tccatcccgg tgatgacccg atatggatcg gcggtgaacg ctacaccctt 2723101 gcagcatgga aagattcgcc tcaattaaaa gaggcaaaag attttatcgc atttatggcc 2723161 cgcccggcca atgccaaaca aatggctgaa gccacatcgc ttccttcagg gctgaccaat 2723221 gtgaaagctg atattttcta cgcaaacgat tatgagtatt atcaagatgt caaagtcgag 2723281 ccttacttcg accggttata cttgccaaac ggaatgtggg atgtcctggg cacggttggg 2723341 caggagctcg cggctgacat tttggcgcct caagacattt cgcagaagct gggaagagaa 2723401 tataaacgac tccgggagca atccgaaaca cagggagctg aaaacaatga gtgagatcgc 2723461 aagggacgtt catgtgaaac aggttaagcc aaaaaagcag tcctcacttt ggtggatgta 2723521 cattcctgct ttgctctccg ttctggtctt tatgatttac ccgtttgtga aaggcacatt 2723581 gattaccttt acaaactgga acggattttc acaagtctac caatgggttg gattcgcgca 2723641 atatgaaagg ctgttttctg atcctgatac ttggcatatc ttaaaaaaca cgctgcatta 2723701 cgggcttggc agcacctttt ttcaaaatgt ggtcgggctt ctgtacgctc tcctcttaaa 2723761 tcaaagcatt aaaacgaaag cggtaacaag aacaattgtg tatttgccgg tgatgatcag 2723821 cccgctcatt atgggctaca tttggtactt tttcttctcc tatgacggag gcgcgctcaa 2723881 cgatttgctc ggggtcttcg gcatcagccc tattaatgcg ctcgccagtc cctcgctcaa 2723941 tccatggatc attgtcatga ttaacaccta tcaatatgtc gggatcgcta tggttgtcta 2724001 cttagccggt ctgcaaagca ttccgaaaga ctactatgaa gcggcgcaaa tggatggcgc 2724061 gaaacaaggc cagcagtttt ttaccatcac gctgccgctg ttaatgccct ccattaccat 2724121 taatatagtc atcaacatta tcggaggctt aaagctgttt gacgtcatca ttgcactcac 2724181 cgcaggcggc cccggaaatg cgtcacaatc catgtccacg tttatgtatg atttgtattt 2724241 caaacggcag gatgccggct atgccgcaac gcaaggcata tttatggcat ttgtcatttt 2724301 gatcatcagc ttttgcgcgc ttgcgtactt taaaagaaag gagacggaaa tgtcatgaga 2724361 gccgcccgta caaaaagcat gcggatcatt acgcttcttg cagccattgt ggcctgtgcg 2724421 cattttattc ctttttatat cctgctgacc acttcattga aagcaaaagg agactacagt 2724481 tcgaaatgga tatttccagc cgacatctcc tttcataatt tttcagaggc gtgggagcgc 2724541 gcttcgctag gaaactcttt tataaacacc atgatcatca caggtttttc tgccttgtta 2724601 ttaattatat tcggctcact tgccgcctac ccgcttgccc ggcgggaaac gaaactgaat 2724661 aaagccgttt ttgccttgct gatttccatt atgatcatcc ctccgttaac gtccatggtt 2724721 cctttgtacc gaatggtcgt ggacgccgga atggtcaata cacacgcaat cgccattttc 2724781 atcaatacag cggcttacat gccgttaacc gtattcttat attcaggctt tatccgatcg 2724841 accattccaa aagagcttgt agaagccgca agaattgacg gtgcaggcat gctgaaaatc 2724901 ttttttacga ttgtgtttcc tctgctgaag ccgatcactg cgaccatctg tatcatttct 2724961 tgtgtcttta tttggaacga ctatcaattt gccattttct ttttacaaga tcaaaaggtt 2725021 cagacattaa cagtagccat ggcaggtttt ttcggagaaa acgcaaacaa ccttcattta 2725081 gttgccgcag cggcacttat ggcaatgctg ccgatggttg ttctgttttt ggcgctgcaa 2725141 aaatacttta ttgccggcct gtcttccgga gcggtaaagg gttaacatta aagggggaag 2725201 caatatgaaa aagattacat ttatcggtgc agggagcacg attttcgcca aaaatgtttt 2725261 gggagactgc ctgttaacag aggcactgaa tggatttgag ttcgctcttt acgacattga 2725321 tcccaaacgc ctgcaggaat cccagctcat gctcgaaaat ctaagagacc gttataaccc 2725381 aagtgtggcc atcaacagct atgatgacag aaaactcgcc ttgcaaaacg caggctatgt 2725441 catcaatgcg attcaggttg gaggatacaa accgagcaca gtcatcgatt tcgagattcc 2725501 taaacggtat gggctgcgcc agacgatcgc cgatacagta ggcatcggcg ggatattcag 2725561 atctctcaga acaatcccgg tcttatttga tatcgcaaaa gatatggagg aaatgtgccc 2725621 tgacgcatgg ttcttaaact atacaaatcc aatggccact cttacaggcg ccatgctccg 2725681 ctataccaat atcaaaacaa tcgggctctg ccacagtgtt caagtgtgca cgaaggattt 2725741 atttaaagct ctcggaatgg agcatgacgg aattgaggaa cgcattgcgg gcattaatca 2725801 tatggcttgg cttttggaag tcaaaaaaga cggcacagat ttatatccag aaatcaaaag 2725861 gagagcgaaa gaaaaacaaa aaacaaagca tcatgatatg gtgcggtttg aattaatgga 2725921 taagttcggc tattatgtca cggaatcgtc cgaacataac gcagagtatc acccgtactt 2725981 tattaaacgg aattaccctg aactgatcag cgagctgcaa atcccgctcg acgaatatcc 2726041 gagaaggtgc gtcaagcaga ttgaaaattg ggagaaaatg cgggatgata tcgtcaataa 2726101 taaaaacctt acgcacgaac gctcaaagga atatggttca agaattatag aagcaatgga 2726161 aacaaacgaa ccattcacct tcggaggaaa cgtcttgaat acagggctga tcaccaacct 2726221 tccttcaaaa gcggttgtgg aagtgacatg cgtcgccgac agaaaaaaaa ttacaccgtg 2726281 cttcgccgga gaactgcctg agcagcttgc agccttaaac cggacgaata ttaatacaca 2726341 gctgatgaca atcgaagcgg ctgtcacacg aaaaaaagaa gcggtttacc aagctgcaat 2726401 gcttgatccg catacaagcg cggagctttc catgaaggac atcatctcca tgtgcgacga 2726461 tttatttgca gcacacggcg attggcttcc ggaatacaaa taaaaactag gggaccgctc 2726521 tcccctagtt ttttggtttt gtttcgcctt cccaggccat catgccgcct tcaacattga 2726581 ctgttttaaa gccttgctca tccaggtact tgcagacgtt catgctgcgc attcctgagc 2726641 ggcagataaa tacgtactct ttgtctttat caagggtttc cattttttca ggaatatccc 2726701 ccatgcgaat atgaacggct tgcgggatca tgccttccgc tacctcttca tcttctctga 2726761 catcaattaa atataattct tcgtccgcct caattttttc tttcaaagcg gctgtgctga 2726821 tttcttttat ttccaaagaa aacactccta ttcacagtga tcatgttcag tatatcaaag 2726881 tcagccgaac gattgctatt ctgagactga tgaaaaaaaa tccccttttg gcaaagggga 2726941 ttttttctag gcttagtttg ccacaatatt gacaagcttc ccaggcaccg cgatgatttt 2727001 ccgaatcgtt ttgccttcaa gctgctcttt gaccttttca tctgcttgag caagctgttc 2727061 cagctgttct ttcgttgcat cggcaggaac ctgtaatttc gcttttactt ttccgttcag 2727121 ctgaacaacg atttcaactt catcatccac aagttttgtt tcatcatata caggccaagc 2727181 ttcgtaggca attgtgccgg aatggccaag cttctcccat agctcttccg ctaagtgtgg 2727241 cgcgacagga gaaagaagct tcacgaagcc ttccatatat tctttcggca gttctgttgc 2727301 tttataagct tcattaataa agaccatcag ctgggaaata cccgtgttga aacgaaggcc 2727361 ttcataatgg tctgtgactt tcatgaccgt ttcatgatag acgcgctcca atgtttcacc 2727421 cgcgccttca acgatttttc cattaagctc accgctgtct tcaataaata ggcgccatac 2727481 acggtcaagg aaacggcgcg caccgtctaa tcctgattca gaccaggcga ttgaagcatc 2727541 aagaggtccc atgaacattt cgtacaatct cagcgtatca gcaccgtgag aggccacgat 2727601 ttcgtcagga ttgacaacgt tccctttaga tttactcatt ttttcgttgt tttcgccgag 2727661 aatcattcct tggttgtaca gcttttggaa cggttctttc gtcggcacta cgccgatatc 2727721 ataaaggaac ttatgccaga agcgggcata cagaaggtga agcacggcat gttctgcacc 2727781 gccgatatac atatcgaccg gaagccattt ttccaatttt tctggtgatg ccagctgatc 2727841 cggattgtgc ggatcaatat agcgcaagaa ataccagcag cttcccgccc attgcggcat 2727901 tgtattcgtt tctcttcttc cttttttccc tgtctcaggg tctgtgactt ccacccactc 2727961 tttaatgttc gcaagcggtg attcgcccgt tccgctcggt ttgatttcat ccgtttttgg 2728021 caaaatcagc ggcagctcct cttccgggac agctgttgac gttccgtctt cccaatgaat 2728081 gaccggaatc ggctcgcccc aataacgctg gcggctgaag agccagtcac gaagacggta 2728141 cgtcactttc ttctcaccgt ttttcgtttc ttccagccaa gcgatcactt tttcaatcgc 2728201 ttcctgtttg tgaaggccgt tcaggaaatc agagttcacg tgctcgccgt cgccagtata 2728261 ggctgcttcc tcaacgttcc cgccttttac gacttccttc accggaaggc cgaatgtttt 2728321 ggcgaattca aaatcacgct catcgtgtcc tggaactgcc atgacagcac ctgttccgta 2728381 tgatgcaaga acataatccg caatccaaat cggcagtttt tctccgttta caggattgat 2728441 cgcatacgct cctgtaaata cgcctgtctt tgttttcgca agatctgtgc gttctaggtc 2728501 actctttgat tgaatttctt tgatataagc ttcaacagct tctttttgct ctgccgttgt 2728561 gatgttttcc accaatgcgt gttccggggc aaggacagtg tatgtagcgc caaacagcgt 2728621 atctggtctt gttgtaaaca ctgtaaagga atcatcatgt ccatctatag caaaatgaac 2728681 gtgagcgcct tccgaacggc cgatccagtt gcgctgcata tctttaatgc tttccggcca 2728741 atcaagctct tccaagtcct caaggagcct gtccgcataa gcggtgattt tcagcatcca 2728801 ctgcttcatt gggcgtctct ctaccggatg gccgccgcgt tcgctcttgc cgtcaatgac 2728861 ttcttcgttg gcaagaacag taccgagcgc agggcaccag tttacaggca cttcgtcaac 2728921 gtaagcaagg cctttttcgt atagctttaa gaaaatccat tgcgtccatt tatagtattc 2728981 agggtcagtc gtattgattt cgcgatccca gtcatatgag aagccaagcg cttgaatttg 2729041 gcggcggaag ttatcaatat tctgcttcgt aaacacagcg gggtcgttcc ctgtgtcaag 2729101 cgcgtactgt tcagctggca ggccgaatgc gtcccagccc attggatgaa ggacatcata 2729161 gccctgcatg cgcttcatgc gggacagaat atccgtagct gtgtatcctt caggatggcc 2729221 gacgtgcaac ccagctccag acggataagg aaacatgtcc agcgcgtaaa atttttgttt 2729281 ttcattatta tcaagagtgg caaatgtttt gttttcaagc caatatgtct gccatttctt 2729341 ttctatctct ttgtgctgaa aactcaaagt aaaaacctcc ttctgattga atacggcgtg 2729401 tatggttcaa gtattgacgg gaaggagagg attatattca gaatattccc aaactaaaaa 2729461 aaactccctc atcccaaaaa gggacgagag actttcgttt tcccgcggta ccaccctcgt 2729521 tagcgcggca tacgccgcac tcacttgata cttttaacgc agttatgcgt cagcggcttt 2729581 tcaccgctgc aactctgagg tgagttcgga aacaaacttg attgactttc accagccgtc 2729641 aactctctgc aacaatatct gtttcttact gctcctcttc attgttctta tcgcaaccgt 2729701 aatctaactg tattttatag aattctgttc ataagtgcaa gcaggtttgt atacaatggg 2729761 aatgtaccct gaacgggcgg agattgagga caattattcg ggtggagttt tggtttgacg 2729821 tttggactcg gccggttcgc cgccgctgtt cagttctctc acaaagtcaa aacttctgag 2729881 aacagcttca ccgccgtagc ctgagataat ggataagatg acaagttgaa ttcctgaatc 2729941 ggggtcagcg gataatacaa gtaaaatgga agccgtcatg ccgataaacc aatcttccaa 2730001 aaatccaagg tagataaacc gcttcgtcat tctgggcttc tccagcctgc ctctcttttt 2730061 cacatgaccg agaatcccca tgattcctcc aattacacaa gcaatgagta cctgatgcag 2730121 catcttcatc atcaccttcc taaagccctt atttcgtaaa gcgacttcag gccatccagc 2730181 ccccttaaac gattccgatg attttcgata tctacatacc ggcaaatctg taaaaagctt 2730241 gtttcttcca ttatatgtga acacatgatc ggtaagcttg atgcattgga ttcatttttc 2730301 acccagtgac attgacctag tcacctattt agcatgtaga aaacctttcc gttcatatgt 2730361 tcaaattctg ttcttatttt tagtgtatac gaggacaagc cctaatgaca aacaacaaac 2730421 tgcacttgct tgaatcagaa catgtgttgt gctacggtta ctgtagaatt catttttaaa 2730481 aaggggaata tcaggctttc gcatagcaag ctgacggcct aagggggatt tatatggcta 2730541 gttttcaatc atttgggata ccaggacagc tggaagtcat caaaaaagca cttgatcacg 2730601 tgcgagtcgg tgtggtaatt acagatcccg cacttgaaga taatcctatt gtctacgtaa 2730661 atcaaggctt tgttcaaatg accggctacg agaccgagga aattttagga aagaactgtc 2730721 gcttcttaca ggggaaacac acagatcctg cagaagtgga caacatcaga accgctttac 2730781 aaaataaaga accggtcacc gttcagatcc aaaactacaa aaaagacgga acgatgttct 2730841 ggaatgaatt aaatattgat ccaatggaaa tagaggataa aacgtatttt gtcggaattc 2730901 agaatgatat caccaagcaa aaagaatatg aaaagcttct cgaggattcc ctcacggaaa 2730961 ttactgcact ttcaactcct attgtcccga ttcgcaatgg catttcggct cttccgctag 2731021 tcggaaacct gacagaggag cgatttaatt ccatcgtttg cacattgacg aatatcttat 2731081 caacatccaa agatgattat ttgatcattg atttatccgg attggcccaa gtgaacgaac 2731141 aaacggccga ccaaattttc aagctgagcc atttgctgaa attgaccgga actgagttaa 2731201 tcattactgg cattaagcct gaattggcta tgaaaatgaa taaactggat gccaattttt 2731261 cgtcgctgaa aacatattca aatgtaaagg atgccgttaa agtgcttccg attatgtaaa 2731321 aagatcccgc tcacccagct ggatctttca gattgttgac aaaatcctaa aatggttttc 2731381 attttaggat tttgtcatct tttcagcgtg attgaaaacc cttgaagtct aggaaggacg 2731441 agcataggag cggagcgaat gttctaattc gtgagcaccg aagcgcaggc ctgacaacga 2731501 atgcgagggt ttgtcgacac gctgaaagat cccgctcatt cggcgggatc ttttattatg 2731561 aagagattga tgcctgctta tttgtttctt tagctgattt tatccgtttg tcatatagaa 2731621 gcgttgtggc aatactgatc agcagcaata ccaacagaga taaaacaaga gccctaatgc 2731681 cgtaatgatc gacaagcact cctccgaaca ggggaccaat cattctgccg cctgtcgccg 2731741 cactgttgac aaagccttga taaaagcctt ctttcccttt aggggcaagc tgattggcaa 2731801 tagtcggcac agcaggccaa acaagcattt ctccgatagt caggatcacc atcgcagcga 2731861 gaaacatcgg aaattgcttt gcagtcagca gcatgctgaa agacacaata aaaatgataa 2731921 agccgatgac catttgcgct tttagcgact cggcccattt tttcaccaca aaactgacga 2731981 gcggctggcc gagcacaatg agaattccgt taaccgtcca cagcacgctg tataaggaaa 2732041 gagatattcc aatgctttgt gtgtacgaag caattgtggt tgaccactga gaataagcca 2732101 gccatccgag tacatagcct ccgcttaaaa tgatcagtgc ggcaaatttt gctttgctgt 2732161 tcacagcatc ataatcaagc acggatgttt gggatgcatc gcccgtttga atatttcgaa 2732221 atccgaaata tacaataaag aaaaagatca gatacaatac ggcatttgcc aaaaatacat 2732281 atgaaaacga gaaagatgcc acgacaccgc caagcgctga accaacggcc acgcccgcgt 2732341 tttgcgcgac atatatcgca ttaaatgcct tccttccccc ttcaggccat accgatcccg 2732401 ccattgcgta gcttgccgga aaaacaacac cggagccaaa gcccacaatc gtcagcagca 2732461 caatataggc tggccaatca tgaaaaaaga caagacccat caggcttgct aacgtaatgg 2732521 ctatcccaag cataatcgat ttaaaaccgc cgattttatc aaacaaaaaa cctccgcata 2732581 aattgccagc cacactggcg ccggaattca gcatcaggac aagtccggct actgttaacg 2732641 actttcctaa atgattatgg atataaatcg tattcagcgg ccataaaaaa gaagcacccg 2732701 tcacattgat aaacattcca atgactaaaa ttttaagagc acgcggcata ctcatccccc 2732761 tttcttacct aaaaaagctc atgaaaaaaa cgaaacctaa aacggctccg tacgaatcca 2732821 gttatcatag cacattcatt ctatctgtct ctctcacatt tttcaactga tgagcgtgaa 2732881 aaaatctaac aaatattgtt tgaaaaatgt aaaataaata gaaaaagggg tcatattatg 2732941 gaaatggtat tagcattctt aggttttctg gcatgtctca ttgcactggg ctatggatta 2733001 tatcaccttg tcagatatgt actgaaaaag gaaaaacgtt tctcaaagag acttttttgg 2733061 ccgcttttca ttggaggcct tgtgctgctc tttaccgggg cagcattggc agaacctgac 2733121 actgccgcag caaatgccga gaaaaaatat tcagcgctaa acgccgaata taaaaacctc 2733181 acaaaagagc acgaagaact tgagaaagaa tataaatctg tcagctctga agcaaagaaa 2733241 ttaaaagaca acaaagaaga tcaagacaag cttgagaagc ttaaaaacga aaatagcgat 2733301 ctaaaaaaga ctcagaaatc attaaaagct gagattaaag agcttcaaga aaatcaaaag 2733361 cagctcaaag aagatgcaaa aacggcaaag gctgaaaatg aaacacttcg acaagataaa 2733421 acaaagcttg aaaatcaatt aaaagagacg gaaagccaaa ccgccagctc tcatgaagac 2733481 actggaagtt cttcaaacaa tacgagtaaa agtgatgaaa ccaaaacagc tgacaaagca 2733541 gaaggctgta atatcaaagg aagcagaaac ggcatctacc acacgccagg cagtacatac 2733601 tacgaccgga caaccgatcc ggctgaaatg ttttgctcag ttgaagaagc tgaagccgcc 2733661 ggttatcggg cgccaaaacg ataaacaaaa agctccagaa tgtctggagc tttttctgtt 2733721 tcacaacgac gatttaatga ccttcttata ataaagaact gacagaaaac caaaaatgga 2733781 gtagagcgca gtatataaca ccatcaccat aatcataggc gcccatacct ctgatccgaa 2733841 taagaaccag ccggattgga cggcaaagta actgtggaag aggccgacaa cgagcggaat 2733901 gccgaagttg tacatttgtt tgatgcgtat cccctttatc aggtcgccct gcgtaaagcc 2733961 gagttttctt aaaattgtat agctcggttt ttcatcttca ctttcaccca tttgtttaaa 2734021 ataaaggata caacctgatg taatcaggaa cgttaaccct aagaagccga cgatgaacat 2734081 caccatacca aacagtgatt tttgcgcagc gcttgtatct agtcttgata aatgctcgtt 2734141 tttcttgttc acctgttgaa aaagctcatt tgctttttcc atttgatcgt catgtttcac 2734201 attgacgccg ataaatgtag attgcgccag ctgaatgcgg gggtctttat ccttgtccag 2734261 ctgtttaaac aggctgtcat ccacaatgac agcgggcatg cccccgcttg taaacgtgta 2734321 ggacacaaga aactcttctc ttaatccttt atattttaat ggctgcgtct cgtgcttgct 2734381 ttttacttta ataacaccag agtccttgaa aaccattatt ttttgcagca agtcggtgta 2734441 tcctgagaaa acggcttctc cagccgccac atcgactcct tttacatctt tgtcgctaac 2734501 aacagcaagc tgcatattgc cgggatcgcc ctgcatctct ttcggagttc catccataat 2734561 atttgcaatg tcaacatttg cttgcaggac aggtgttgcc ttttttacaa acgagatgtt 2734621 gctttccctc aatttgtttt caaataactt ggcatctttc tcattcatga atgaaaaatc 2734681 agccgctaca ttttgttcag cggtcttttc cgacgagtaa tacgagatgt aagcaagaga 2734741 taacagcccg atggcgagcg ctgaaacggt tgtaataatc gtcagcagca gcgcattcga 2734801 tttcattctg aacatgatcg aagacagtga cagaacctca gaaatattta agtagccgcc 2734861 cttgcttttt cgaatgatat tcgagataaa cgtaactgat cctttataaa acaaaaacgt 2734921 cccgataatg acgctcccca gaatgaagct catcgcaaca aacagttcat taatggtctt 2734981 aaattttccg ccaaacagct cagaagacac atagtatcct gtcaaaatca acacgatgcc 2735041 taaagcgccg atcagcattt ggaaaaatga tattttcttc actttgtctt cagtggagga 2735101 cgttacttta aacaaagata aaatactctg ttttttgata aacgtataat tcatgatcat 2735161 gatcaaaagg taaatgccgc agaacacaat gaccgtttgg accaaggcct gctcagaaaa 2735221 atgcagtttc gcatccgctt tgacatcgac aattttgaac agaatcatca agacaagctt 2735281 cgatatcgaa aacccggccg ctaccccgat cgctaatgaa ccgaaataca gcatgacatt 2735341 ttctgcactt aagatgcgaa aaattttatg cttcgtcatt ccaattaatt gaaacagccc 2735401 gatttcttta ctccgtctct taataaaaat cgtattggca tataaaatga agatcgccac 2735461 tacagccaca agcaaaatcg aagcggtttt aatagccgcg gctcccttga ttgaagcctt 2735521 cacttcgtta attgctggat catactgcag cgtgacaaag gcgaaataaa gcgccacgct 2735581 aaagatgagc gcaaacacat acaaatagta attccggaga ttctttttca aatttcgcag 2735641 gatgagctga ttaatgttca tgctgcaccc cgcctaacac gccttgcgtt ttcataatat 2735701 cctggaaaaa cgtttgcctg tcctggcccc ctttattcag ctgtgtatac atttgcccgt 2735761 ccttaataaa aatgactctg ccgcagtagc tggcagcgac gggatcatgg gtaaccataa 2735821 taatcgtcgc gttgcgtttt tgattgagct ggctcagctt atttaataga tcggaggccg 2735881 atttcgaatc gagcgcgccg gtcggttcat cagcgaaaat aatgctcggg tcatgaataa 2735941 acgctcttcc agcggatgtt ctctgcttct ggccgccgga aatttcattc gggtatttat 2736001 cccgcaattc atatattccc agttccttgg caacttcctc aaacttgcga ttggcttcct 2736061 tttttgatag tttcgtgatc gataaaggca gaaggatatt ctctttcact gtcaatgtgt 2736121 ctaacaaatt gtaatcctga aagataaagc ctaaatgctg ttttctaaat tcagccagct 2736181 gcttttcctt catagccgtc atgtcatttc cattaatatg aatggttccg tgactgacct 2736241 gatcgattga ggacagaacg ttgagcaaag tggtttttcc cgacccggaa gcacccataa 2736301 tactgacgaa ttcgcccttt tcaatgtgaa tatcgatgcc cttcagcact tcctgtttat 2736361 tcagcttgtt tccataactt tttcgaattt tattcgcttc taaaatcacc atttacgcag 2736421 tctcctttat attggataat ctcattataa aaaggaatgc cgggcttttc cttcgatacg 2736481 gcgaacaaaa aagaaaagca tgtgacattt tcgtcacacg cttatgacat gttcaaattg 2736541 attccgtatt ggaaaggtta atgtaaaaac tgttcccgca ccaaactccg actcaacatc 2736601 aatatggatc aataacggcg ccgctgcttt ttttgccaag tacagcccca tgccagttga 2736661 cgcttgatca tggtgatccg ttgtggatgt aaacccttta tcaaaaatac gcggtacatc 2736721 ttttggatca atgcccctgc cacaatcttt cacttggagc tgcgtctgtt cccctttttg 2736781 aaagcttttg atctcgattt cagaggcttc gctgtatttc accgcgtttg tcagcagctg 2736841 cctgatgata aacgccagcc attttgcatc gctcagcact tctttggcct cgagctgtat 2736901 gtcaaaaccg atcccttttt ggatacacca cgattgtaaa tctttgattt ctttaaagat 2736961 caaaggctga agctgaatga attctactga caggtcgttt tcaataaatg aaatgcgttt 2737021 ttgatgaagc tgctgatcaa gaagcaggtg aatacgcagc cattcatatg acagctggga 2737081 tttcagtgct ttttcttcca ttctatcaat gattaaatgc atcgctgtta atggagtttt 2737141 gacctcatgg atccatgcca tcagctcatc tttttcattt tccaatgcta agcgatgccg 2737201 tgctgcggtc tgcttcaagt gttctgtttg cccggcaatg cttctttcaa ccattgcttc 2737261 aaacggcgtt tccggttcat ttatggctgt cacatcgaga ttgttctccc atgttttcaa 2737321 gcttttataa aacgctgttt ctttccgata gcggaaccaa aggaatatga taaaaaacaa 2737381 gatgcacaaa tacaccatat aaagtacatt cccaaatgat atggaaggat cgacaaaagc 2737441 aatgaacagc atcaaagcct gctgaaacaa aaacgcggca atccagctcc gcctttcgat 2737501 aaggaatgct ttaatcatag aacttgtcct cttccttcgc gatgtagccc tggcccacct 2737561 ttgtctcgat atatgcacca agctgcaggg cgtccagttt ttttcgcagg cgattgacat 2737621 tgacggtcag cgtattatca ctaacaaaac gctcatcgtt ccacaagctt ctgatcagct 2737681 cttcccggct gacgatcttg tttttttgct ctattaattg ttttagaatg aacatttcat 2737741 ttttggtcag ttcaacagat cctttgtcat tgctgacgag gttctgctcc gcgtctacag 2737801 cagcgccgca ccacgtttta atcgtactcg gctccgtatt ataatggtgc acacgccgga 2737861 acatcgcttg gattttcgcg atcagcacat caaaatgaaa tggcttttga ataaagtcat 2737921 ctgccccgag ctgcatggac atcaccatat cagcaggatg atcccgggag gataaaaaga 2737981 gaatcggaac atttgaccgg gagcggatca gacggcacca atgaaagccg tcaaatttag 2738041 gcagctgcac atcaataatg acacaatcag gattaaccgc cgcaaattcc tgcagcacct 2738101 gactgaaatc ctgaatgccg tatacatcat aggaccatcc cgttaaacga tccttgattt 2738161 catgaaacag cgattcatca tcttcaatca gcaaaagttt aaacaatcga ctcaccgcac 2738221 tttttccttt tttatcaagt gtatagcaaa acgccagcat gcgctataga aaaagccggc 2738281 tgtctcagcc ggctcgttcg cattataatt ctcttctcaa cgctgtcagc acgttggttt 2738341 tggtagcttt tctcgccggg ttcattccgg aaatgactgc gacccctccg caaatcacaa 2738401 cggcaatgat cacaaggctc gccgggatgt aggagaatgt gtaattcaaa tcgcccgcat 2738461 cgccaccgct tgtggccgca agaatcatcg gaacggccag gttgacaagg tagctcacgc 2738521 cgtaagaaat gataatccca atcacacagc ctaaaattcc gatatacgcg ctttccatca 2738581 agaacattcg gcgaatgatt gacgggctcg ccccaatcgc tttcataatg ccgatctctt 2738641 gcgttctctc tgtcaccgcc atcgtcatcg tgttaaaaat gccgatcgct gaaatgataa 2738701 ctgcgataca tccgacaaag atcagtccga ttttgaagac catgaagaag gtattggctc 2738761 cctcaagttc agtagtcact gatgtgacat agtacccgtc atctgttaga tcatttgtca 2738821 gctgttccac attctcaaac ttatcagcaa aaacaccaat gttcgtttca acatttccgc 2738881 ctttgaaatc taagaattcc gaaaaatctt ttttgaattg atcactgata aaaatatttg 2738941 agtcctccat ccagtcttga gatggttttt ttgtaatacc gacaatttta aagtcatatg 2739001 tttttgtttt tgtaacatcc cctgttttag aatctgtctt cgatacactt agttcaattg 2739061 ttttatttag aatatctttc gtatagccct ttggttcttt tatatcttct ggatttcctt 2739121 ttgcttcctc gatttttttg ttatattctt ccgattcttt tttcgttaat aatctctttg 2739181 cgaagtcgta tcctactacg atttcatttt ccgactttgc gactcttccc ttttccaatt 2739241 ccatattggc ctttaattca tcattcatat tagtaaaaat gagatttgag ctttcatttg 2739301 tacgattgcc taaagtagct ttgtttggtt catacacttg cgttctttct acaactgacc 2739361 ttacgtgatc atacttctct aaatcagctt ttttaatcgg cttgtctcct tccttgccca 2739421 ttacgctgac tttcgttaca atctgctggc tcattgtcat atctgtaatc gtcttttgaa 2739481 tcccaaatcc aacggacgac aacacaacca aaaacgcaca cgccattgtt gtcgccagaa 2739541 tcgtcataaa gacgcgaagc ctgtttttct tcatatttct tctgataaaa tgaacctgat 2739601 ccttaaacct caacggtaat tcctcctttt agcacaccat catgaagctg aaattttgaa 2739661 tgtccgatag aagcgacttc atcatcgtga gtaatgatca caaatgtaat gccacgctca 2739721 cgattcagct gctggatcaa ttccagcact tcatgttccg tttctgaatc aaggcttccc 2739781 gtcggctcat ccgctaagat aatcgaagga tttaaaatca atgctcgagc aatactgaca 2739841 cgctgctgct ggccgcctga cagttcattc ggataatgag cggcgtggtt ttccagaccg 2739901 acgcgtttca gcatgtcctg caccttttgc ttccgctcag atggcttgat tccttttaac 2739961 gccagcggca tttccacatt ctcatacgtc gttaaacccg ggatgagctg aaagctctga 2740021 aaaataaacc cgaaatggtc aagccgaaat tgcgcccatt ccttttcatt aaaccccgta 2740081 acatcagtgc cattaatgac aatccgccct tttgtcggcg atatgtagcc ggaaattaaa 2740141 ttcaaaagcg ttgatttccc tgagccgctt cgtccgacaa tgcaggcgat ttcccctttc 2740201 gccacgctca atgaaacatc cttcaatact ggaacttcat tctcacggcc cttttttccg 2740261 atcgtgaaag aatggtcgat atgctgaaca tcaatcatat gttctctctc ccttacaaaa 2740321 gtttcatttt tttataaatc gcaaaataac taatcaagaa accgattacc gcacctgtac 2740381 ccatgccaat gagataaccg gcaaagctct cgcttgcagt aaatccaaaa tagccgaagc 2740441 ccatgattcc tatgataata acgatgatct gcaccgggcg gttaagcggc ttccataaga 2740501 agaaatatcc gtttctttca ttagacattt taacaaagct aatatagccg atgatgtaaa 2740561 aaatgatagt catgatagcc ggaatgacta aataatatgg tgaattctca gcccatttcg 2740621 agtctacata aattatcgga atgaaatact gcacccattt aggtactgga ccatggataa 2740681 aatctattga tccgccaaaa aggatctcga ggttgatcac aggcaggctg atgagtaaaa 2740741 acggcgaaat ggccacggta aatgagacta gaagctgtgc gaaactattg cctgtcaaag 2740801 ctcctccggc cataaccaaa gaataagcca gcatgctaac aataatcatt cccaagctgt 2740861 aattgtgaaa ataaacggcc tgatctggct tcaaaagcat gatcagcaaa acagacaaaa 2740921 cataacctat gagctgcggc accacaatca ccattccgcc ggtaaggaac ttcgcatgaa 2740981 atatctgccc tcgtgtatat ggaaggctta atgtaaaatc aaagaagctc ttgctacgtt 2741041 caatcccaag ctggctgacc gccaaaacga ctccccaaat ccaaaacaat gagataaatg 2741101 agctatttaa ataatcaacg ctgaatacgc aggggccgac ccaattttct tttccagtga 2741161 cacagccttg atagatgaga tacatattta aaattgataa tggattacct aatataaaaa 2741221 ccaaaatggt gataactaag gcgactttat tctgccgcca ctctttgtaa agcagtccgg 2741281 aatccggcaa ctcacttccc tccaaaccta aggcatttct tacacttttg ttttcttata 2741341 aatagagaag tagctcacaa agaatccagc cactgctcca atgatcatac ccaaaatata 2741401 accaataatg gaatgtccgg tatagtatcc aaataaacca aatccaagga tgccgaaagc 2741461 cataaccaga atttgcaccg ggcgatctaa tctgttccat aagaaaaagt gtccgttccg 2741521 ttcacttgga agcttcttga agcttataaa gccaatcaag taaaatagca tgctcattac 2741581 ggctggaatc aataaaagat atttactgtt aatcagccat tcatttacaa cgtaactaat 2741641 cggtactagg ttcgataaat tgcttgccag agagaaataa ctctcagggg aagggaatat 2741701 ttcccatata ttcgcaccaa aaacaacttc taggtttcca accggcaatg caataattaa 2741761 atacggcaat atagctgctg aaaacgccgt taacagttgg gcaaaagcat ttccagttaa 2741821 cgctccggcg gccatcacca gtgaaaaagc cataaaactt atcacgatta ctccaatgct 2741881 gctgtgctca aaaaagtaga cgtgttcagg gttatagaca agaatcagca gccatgcaag 2741941 taaaaagcca atcaattgtg acagcacaat cacaaaaccg cctaaccaaa attttgtctg 2742001 aaaaatttgg cttctgttat acgggaggct taatataaaa tccatcgtgc ctttcgaacg 2742061 ctccattccg aggaagcaga ccgccaaaat gacacccggc acccagttga tatctatcag 2742121 attgcttatg gaataattca caataaaatc acaatattgc gggtcttggc gatcaagaca 2742181 cccttgataa gacaaatacg tattaacgat agaaagcgga tttgccaata ctaaaaacgc 2742241 gatacttaac aaaatcacca cttgattctg cttccactct cgatagagga gacctcggtc 2742301 taccatctcc gcttccctcc aaacttcgca atgaacactt cttccaggtt gacaggaagc 2742361 tcattccaca cttttggctt cagctctctc aaaaagctct ttttctcctc atcgcttttc 2742421 ggaatcagca ctgtgtaaaa cacgccggcc tgatcgagca tcggaatgtt ttgctctctg 2742481 atggccaaat tgacatctgt atcgaaggcc atttgaattt taatgtattc ttcttttaac 2742541 tcatcaagat ccatgacgtt ggtcaggctg ttatcttcaa gaaaaccaat tcggttgcac 2742601 atccgctcta tgtcttcaag ccggtgggac gtaatcagga tgctcgtatc acgctctgcc 2742661 acttcatcga ccatcagctg cagcacatca tgccttgtca ccgcatcaat accatccgtc 2742721 ggctcatcaa ggaggatcag cgccggtctc gccgcaaacg acagaacgag cgatagctgc 2742781 ttttttaagc ctgtcgacag ctcacggtat tttttcgttt ccggaatttc gtatctgttc 2742841 atcagctcat tcgcgtacgt gacatcaaat ttcggatata ttcttctcaa aatatcgact 2742901 aactgcttgt atgtatactt atcgtaaaac ggattttgaa caggcatgta gatgatattt 2742961 tgtttgactt tcgggtgctt tttgatttct acgccgtcaa ataaaatcgt tccgctgtca 2743021 gcgaaaatga tttgctggat taagcgaagc atcgtcgttt tgcccgatcc attgcgtcca 2743081 agcaatccaa agatttctcc tttttcgatt gttaatgaaa catcttttaa tacttgattg 2743141 ccgtcaatcg cttttgacag ctgccgcagt tcaatcattt tttttgcctc ccttcacatc 2743201 agcgctgatt tcctttatcc attcgtgcag tttttccagc tcaacccctg catagtgtgc 2743261 atcgatgatg agctgtttga gttgctcttt aatcatcgtc atcttccctt caaccagtgt 2743321 cgtttttgca ttctccgata tataggtccc tctgccccgc agcgtttcaa taatcccctc 2743381 tcgctcaagt tctttatacg ctttgctgac agtgttcgga ttcgcaataa tgatcgttgc 2743441 caattctctg acagaaggaa gcttatcacc aggcttcatg atccctttca aacaaagctc 2743501 tttcatttgc tgaataattt gttcgtaaat gggtgttgag cttcttggat cgatttgaat 2743561 catttacttc cctactttct atacgatctg aaccttttat agataaaaat gatcaattat 2743621 acttttttgc cattcaaaac cgatcatcac aagaacaaga aaaaaagaac aagcgatcac 2743681 agatgccgca atcagcattg gcacgttacg tttgtttcgt tttttatgtt tcataactgc 2743741 ctcccttaat gtcaatatat aaatgatttt atattagtgt ctatagtgta ttacttcaat 2743801 tagtacactt aatacaataa atactttgac tcacaaagtc aatccttttt ttacaaaaaa 2743861 acggaccctt ttaaaagggt ccgttttcct acacatcaag agggtgctgc aggatcatat 2743921 tattttgcaa agattgaagc tgaagtctca ttctgtacag ctgttctctc tgctgatcat 2743981 ttgacgacag ccatagttta ttcaaggcat ttaccgcatc ttctagctgc atttgtgcat 2744041 cactatattc ttgatcgtta taatgctctt gtttagaagc gattttcagc tgttcttcag 2744101 cataatcata ggcctgcata cattgctgga gatgttcatc tactgattgt cttgttgcca 2744161 cagtaacccc tcctcttggt aatggaaatc atccatcatt catattgtag cctcatctga 2744221 ctttattcaa taaagtaatt tatggtcgat attcatttgt tctcttgtga aatgcgtgct 2744281 acaattttag gatgcaatcg tacgcaagga ggcacatgaa ttgtgatgca gaacaatcct 2744341 tttccttatt caaatacgga aaaacgctat catacattga attatcatct cagagaacat 2744401 ttcggccata aggtgtttaa agtagcgctt gacggcggtt ttgactgtcc aaatcgggat 2744461 ggcaccgtag cccacggagg ctgtacgttt tgcagcgcag caggctccgg agattttgct 2744521 ggaaaccgga ccgatgattt aattacgcaa ttccatgaca tcaaaaaccg catgcacgaa 2744581 aaatggaagg acggcaagta catcgcttat tttcaggctt tcacaaacac tcacgccccg 2744641 gttgaggtgc ttcgtgagaa attcgaatcc gtcctcgcct tagatgatgt ggtcggcatt 2744701 tcgatcgcca cacgcccgga ctgtctgcct gatgatgtcg ttgattactt ggcagagctg 2744761 aatgaacgta cgtatttgtg ggtggagctt gggcttcaaa cagttcatga acggactgca 2744821 cttttgatca accgcgcaca tgattttaac tgctatgtgg aaggcgtcaa taaattaaga 2744881 aaacacggca tacgtgtctg ctcgcatatt atcaacgggc tgcctttgga agaccgggac 2744941 atgatgatgg aaacggcaaa ggccgtcgca gatttggatg tccagggcat taaaatccat 2745001 ctgcttcacc tactgaaagg cacgccgatg gtcaaacaat atgaaaaggg caagctggaa 2745061 tttctttctc aagatgatta tgtgcagctc gtctgcgatc agcttgagat cattccgcct 2745121 gaaatgatcg tccaccgcat tacaggtgac ggaccgattg agttgatgat cgggccaatg 2745181 tggagcgtca acaaatggga agtgcttggc gccattaata aagagctaga aaatcgaggc 2745241 agctatcaag gaaagttctt tcaacggctt gaggaggaat cagcgctatg attttgaaga 2745301 aaattcttcc ttacagcaaa gaactgctga aaatggccgc gggagaggga gatattgtcg 2745361 tagatgcgac aatgggcaac ggacatgata cacagttttt agcggagctt gtcggtgaaa 2745421 acggccatgt atacgcattc gacatccaag aatcagccgt ggccaataca aaggaacggc 2745481 tcggtgacat gtatcaagcg cgaacaacgt tatttcacaa aagccatgat aaaatcgctg 2745541 aatccctccc gcctgaaaca catggcaaag tggcggccgc ggtatttaac ctcggctatt 2745601 tgccgggcgg ggacaaatca attacgacaa acggcagttc tacgatcaaa gccattgaac 2745661 agcttctcag catcatgaaa gacgaaggtc tgattgttct cgtcgtctat catggccacc 2745721 cggaaggcaa agctgaaaaa aacgacgtgc tcgagttttg ccgggacttg gaccagcaaa 2745781 cagcccgtgt attaacatac gggtttatca atcagcaaaa tgacccgcca tttattgtcg 2745841 ccatcgaaaa aaaagctcag atcagcaaat gatttgagct tttttctttg aatttttcat 2745901 ccaggacatt ttttgaaatt tccggtaggc tctgccgttg atataaaaga aaagggaggt 2745961 ttttccgctg gctttgatca gcttctttgc gagccggccc atttcctttt ggcctgccac 2746021 tttatcatct gacaaataaa cgccaagcaa gccgcgattg attaaacgat ggaagttttc 2746081 atgcggaatg ccttgtaaat gctcgtcggc tttatggata aagtgttcaa gccggtccat 2746141 catctcttca tgagactgat aatacgagca gaaattcaag tctccttcca gcaagtcctc 2746201 ctcttgatca atcaaataat caagaagaat atgaagaccc tgtatgtaag gaaaataact 2746261 gtctcggatt tttttagcgg tgctttctgt gaaatcaggc tggaacgaat acgcaaccag 2746321 acagaaaatg cctaacgttg agcctgcaca ggctgaaaat tcataccatt ccatctcagg 2746381 cagctctgat tcatattgag taaaccactt ttcaagccgc ggaacacgct catgctcaat 2746441 aacgtgctta tgcacctgca aatcgcaata atagccgcac agttcaagca gataaggttt 2746501 aatcatgtca tagtgctcaa tggagccgag aacacgctgg cacgttttaa ccagttcatg 2746561 caaatatccg ctgtcatcct gttcttccct gaattgataa tagttttgca gttccgcccc 2746621 aactgtcagt gcgtcctgca ttgaggcatg gagcatccga aaatcctgcg ggtccagcga 2746681 ggtgctgcgg tcacacagat tgtccaaata atcactaatc gtttgatacg cgatgataaa 2746741 ctcgacacat ttctgctttt ggctgcctga caataaggcc agtatgccgc cgccttcaca 2746801 gtgaaacgtt ttgtcccgaa tacttgcggt tgcctgtgct ttcaattcac tgttatgaat 2746861 cgattctgat ttttgcttcc atatgtccag ctcttgatga acgagcggaa aaatatctcg 2746921 atataccttt gccatcaatc caaaaggatg ttccggtact gtcaacacat gcacccccta 2746981 ctagttcaaa tatattgatc agtaaacgct cttgctgctt taaaaacatc ttctctctcg 2747041 ggttcattga agatctcatg gtaaagccct tcccactctc tgtatgcttt attatgagaa 2747101 gcaacaccat taaaccactt gatgaccatc gttttgtcaa caagcttgtc atcaccggct 2747161 tgcatcacaa gaagcggaac tttcaaaaat gcctctgtcg gcaccattgc cgattcaatt 2747221 gtctttaaaa gctctctgta ccatctgaca gaaactttcc tgacgtataa cgaatcattt 2747281 tggtcagctt cgatgacgtc ctcattgcgc gtcgccatat caattgataa tcccgaatca 2747341 accttaagtg acggagcgat gacattcagg ccttttgatg caagatcaag cgctttattc 2747401 actttaattt gcagtccgag acacggtgat gataaaataa ttcccgtaat ccggggattt 2747461 ctttgctgtt taacccattc aatcgcgacc agaccgccca tgctgtgacc tagaagaaaa 2747521 accggaagat caaaggttcg cgctttatct atccaagcat ctacttcatc aatgtattct 2747581 tgaaacgagc gaatatgccc tctcgctctt gtcgttgttc cctgtccagg caaatcgccc 2747641 atgacaacgt gataacccga agaccgccac atttcaatca gccatttata tcgtccgtga 2747701 tattcacttg ccccgtgaat gattacaatc acggcaacag gtctgtctgc tttccaggtc 2747761 cacatgatct tcacctcata cgaaatttaa atagagaaag aaggatgaat cttatgatct 2747821 acccttataa ggaacacaag ccagatatcc acccaacagc ctttatagct gataatgcaa 2747881 caattaccgg tgatgtcgtg atcggagaac agtccagcat ttggttttct gttgtcataa 2747941 ggggagatgt tgcgccgacc agaatcggaa acagagtcaa tatccaagat ttaagctgcc 2748001 tccatcaaag cccgaacaag acgctactca ttgaagatga cgccacgata ggccatcagg 2748061 ttacacttca tagcgctgtt atccgcaaga acgccttaat cgggatgggc tcaatcattt 2748121 tagacggagc cgaaattggc gaaggcgctt ttattggtgc cggcagtctt gtcccgcccg 2748181 gaaaaatcat tccgcctggc catctcgcct ttggccgccc tgcaaaagtc atccgccctt 2748241 tgacggaaga agaccgaaaa gatatgcaaa gaatacggtc agaatatgta gaaaagggcc 2748301 aatattataa atttcttcaa caaacataag acctgcttcg tcttacttta ccatttttca 2748361 aattatattt gaaagcaata accatcgtta acccggacgt catacagttc gggtttcgat 2748421 ttttccataa aacgttcaca tatagcatga aacgtatgac ttttatctta tcacaaaact 2748481 ataaacagcc tctgcaaaaa cacataccta ttctttcctg ttctctattt tctatgagca 2748541 cacacaaaaa gagcccactg ggagctcttt ttgtcagctg atatttcgtt cgctggcagc 2748601 agccgcattt tttttatgaa acccttttcc atagtacaca gccagcaaga tgagaaacca 2748661 tatcggcccg ataatcacgg ctactcttgt atcagggctg taagccataa gaatgacgac 2748721 gaatgctaga aatgccaatg acacataaga cgtaaacgga aataaaggca ttttgtactt 2748781 taattgtttc ttttcttccg gcttcaaact tttcctgtat tttatttgag aaagcaaaat 2748841 gattgcccac gtccaaatcg ctccgaacgt cgcaatactt gtaacccaag taaatacctt 2748901 cgcagggaca acatagttta acagcactcc gactaataaa gcgcccgctg aagccagaac 2748961 agctttaccc gggatgccgc ctttcgtcag ctgaccatat gcttgtggcg cctctttctg 2749021 ttccgccaag ttaaacagca tccgccctgt gctgaaaata ccactgttgc atgaagacag 2749081 cgcggctgtc aacacgacaa agttaatgat acctgcggcc gatggaatgc ccactttttg 2749141 aaatgtgaga acaaatggac ttccttgaga gccaatttcc tgccacggat aaatagacat 2749201 aatgacaaat aaagcgccta cataaaaaat caaaatccgc caaaatactg tatcgattgc 2749261 tttggctaac gatttttgcg ggttttttac ttcgccagcc gtcaccccga tcatttcaat 2749321 ccctaaatag gcgaacatga ccatttgaag agacaataaa acccctttta atccatgagg 2749381 gaaaaatcct ccgttgttcc acaaattgct gattccggtt gcaatgcccc cattgccgac 2749441 tcctgcaata atcatcaata aaccgacagc aatcatggat aagattgcaa caattttaat 2749501 caatgcgaac caaaattcca gctcgccgta agctttgaca gccaggaaat taacacccgt 2749561 cataatgacc agtgccgata acgcccaaat ccagtttggc acgtccggaa accagaaccc 2749621 catatagatg ccgacagcag tgatttcggc catacaggtg acaacccata aaaaccagta 2749681 gttccaacct gttaaatagc ctgcaagcgg tcccaaataa tcacgcgcat acctgctgaa 2749741 ggagcctgcg accggttttt gaatggccat ttccccaagc gctctcataa taaaaaacat 2749801 gaccaggccg cttgcggcat acgctaccaa aataccaggc cctgctaatt gaatagctga 2749861 tgcggagccg aggaacaacc ctactcctat agcagctcct aaagacatta aagaaatatg 2749921 cctttcttcg agtccgcggt gcagctcttg tttttgtttt tgcatgcttc ttctccccta 2749981 gaaaaaaata tcattatatc atttttctga atattccgta cggattgggt aaatcaatga 2750041 tgatggagaa ataaaaggat aacaacaagg ctttcgacta ctcgaaagcc ttgttgtctg 2750101 ttacacaaag atgacttctt taggctgatg gctcagctct tcaggcatat accgtttttc 2750161 aatattgatg ctgtgccaga tcataaagat tagcacagtc caaattttac ggctgttatc 2750221 agccttgtcc gcacaatggt cttcaagaag ctgaaggaca taatccttat ggatataagc 2750281 atccgtttgg ctttcttgaa taatattccg cacccattcg ttcatttcgt ttttcagcca 2750341 atgacggatc ggtacaggga aaccaagctt tttgcggttt aatacgtgct caggcacaat 2750401 tccttcagcg gctttgcgaa gaagatactt cgtcgtgccg ttcttcgttt tcagctcatc 2750461 aggaattttt gaagcgacgt cgaatacgac tttatccaag aacggcacac gcagttccaa 2750521 agaattcgcc atcgtcattt tatccgcctt taacaaaatg tcgccgcgca tccaagtgtg 2750581 gatatcgaca tactgcattt tgttgatatc gctgtacgag ctgctttctg taaagtaagt 2750641 cttcgtcaca tcgcgatatg aaaggttcgg attataatgc ttcaacagct gctttttgac 2750701 agactcttca aagattttcg cgttaccgat ataacgatcc tgaagcggag tgcagccgcg 2750761 ctcaagcagg ctcttccctc tcataccttc aggcataacg gcagcaacgt gcagaagcat 2750821 ctttttcaag ccggacggaa tccgttcaaa cggtttaagc gaaagcggtt cacggtaaat 2750881 gttatatccg ccgaagagct catccgctcc ttcacctgat aaagcaaccg taacatgttt 2750941 ttttgcttct tttgcaacaa agtacaacgg aatcgctgcc ggatcagcaa gcgggtcatc 2751001 aaaatgccat acgatcttcg gaagctcatt catgtattcc tcaggcgaaa tgactttgct 2751061 gatattttca atgcccagcg ccgctgccgt ttctttcgct acatcaacct cactgaagcc 2751121 ctgctgttca aagccgacag agaatgtttt taagcttgga tgaaattcct tcgcaacaga 2751181 cacaataaag gaagaatcaa tcccgccaga caggaacgaa ccgacaggaa cgtcacttct 2751241 catatgaacg tttacagagt catagatcgc gtctcggact tctttcacaa gcttgtcttc 2751301 ttcagtctga accggcttga agttcgcttt gaaatacgtt ttgaatgtga tatcgccgtc 2751361 cgggcggatt gtgaattgtg aacccggctc tacttttttc acatgggcat caagcgtgct 2751421 tggttcagga acaaattgga aagacatgta ctgctgcaat gcctctttat ctatttcaat 2751481 atcattctga gcaaccatta aactttttct ctctgaggca aaataaacct gatcattgat 2751541 cgttgtgtag tacaacggtt taatgccgaa tggatctctt gccccataaa gcacatgatc 2751601 gtttttattc caaatcagaa aggcaaacat accgcgcagt ttggacgccg cttcttcttt 2751661 atagtgacgg taagtcgcaa gaagaacctc tgtgtccgaa tccgtgttga atgtgtaccc 2751721 ctttgcttca agttcttctc tcagttcgat atagttatag atttctccgt taaagataat 2751781 ccaatatgtt tcatcttcat atgataaagg ctgtccacca ttttctacat caataatgct 2751841 gagccgtctg aatccgaagc cgacgtgctc atcatggaaa tatccatcac tgtcaggacc 2751901 gcggtgaacg atcatttggt tcatttgttt gattagttct tcttgatcag cggtttgagc 2751961 taacggatgc ttgttaaaaa ccccgacaaa tccacacata gtattgcctc cataattaaa 2752021 attgtcatca ttgaacccct atttatagac gctgtgaata gtatttggtt tcacagttat 2752081 gtaaaaaaat aaacatgaat acaacgataa aaaagggaaa gccgcttaac cagtaagcgg 2752141 ctataaaatt attctcctaa cgcttcttta cgcagctgct ccgctttgtc tgtgcgctcc 2752201 catggaaggt caacatcgtg acgtccaaag tggccgtacg cagcagtttg tttatagatc 2752261 ggacggcgca aatcaagcat tttgataatg ccggcaggtc gtaaatcaaa gttattgcga 2752321 acaacttcaa tcagtttttc ctcagaagct tttcctgaac cgaatgtgtt gattgagatt 2752381 gacacaggct gtgcaacacc gatcgcgtaa gcaagctgta cttcgcaaga atcagcaagc 2752441 tcagccgcaa cgatgttttt cgcaacgtat cttgccgcat aagctgcaga acggtctacc 2752501 ttcgtcgcgt ccttacctga gaacgcgcct ccgccgtggc gtgcatagcc gccgtacgta 2752561 tcaacgatga ttttgcgtcc tgtaagtccc gcatcccctt gagggcctcc gattacgaaa 2752621 cgtcctgtag ggttgatgaa atattttgtt tcttcatcaa tcagctcttc aggaacaacc 2752681 ggattgatta catgttcttt aatgttgcgc tgaatttgct caagtgtaat ttcagggtga 2752741 tgctgagttg aaataacaat cgcgtcaatg cggactggtt tgttattttc atcgtactca 2752801 accgttacct gtgttttgcc gtcagggcga aggtacggaa gaatatcttc tttacggact 2752861 tcacttaggc ggcgggctaa tttatgggca agtgaaattg gaagaggcat aagctctttc 2752921 gtttcgttgc acgcataacc gaacattaat ccttggtcac ccgcaccaat cgcttcaatt 2752981 tcttcgtcgc tcattgtgcc ttcacgggct tcaagcgctt ggtctacgcc catcgcgata 2753041 tcagcagact gctcatcaat tgatgttaaa accgcacaag tttccgcatc aaatccgtat 2753101 tttgcacgtg tgtatccgat ttctttaatg gtttggcgaa ccgttttcgg aatgtcaaca 2753161 tacgtagaag ttgtgatctc tccgcttaca agaaccaaac ctgttgtcac agatgtttca 2753221 caagcaacac gcgcgttagg gtctttcttt aaaatttcat ctaaaatgct gtcagaaatc 2753281 tggtcacaga ttttatccgg atgcccctcc gtaacagatt ctgatgtaaa taaacgacga 2753341 tttttactca tgatttgctt cctcctgcac aaggcctccc gaaagacctt gtatatatga 2753401 tacggaactc gctccctctt atacaatgta cagttatatt agagaatgtt aattggcata 2753461 tttatgaaat aaaaaaacct tttccatcga ggaaagggtt tggtctttgt gcctttcact 2753521 cttatcgctc aaggaatcat acaaccttgc aacaggttag caccttggtt gtctcactca 2753581 gttgaacata ataaataaca gagaaaccgg ttgctgggct tcatagggcc tgtccctccg 2753641 ccagctcggg ataagagtat ccgctcaatg aaatatctta tcgtaaaagg gtttgcaatg 2753701 tcaatatgat tcagaagaaa taggcaccta tattgaggga aaacaatgga aatgcacaca 2753761 caaaaaacaa taaatagtat agactatttg aaaatatatg ttatactaat tcacaattag 2753821 caaaacacaa aaaacgataa aggaaggttt catatgaact cagttgattt gaccgctgat 2753881 ttacaagcct tattaacatg tccaaatgtg cgtcataatt tatcagcagc acagctaaca 2753941 gaaaaagtcc tctcccgaaa cgaaggcatt ttaacatcca caggtgctgt tcgcgcgaca 2754001 acaggcgctt acacaggacg ctcacctaaa gataaattca tcgtggagga agaaagcacg 2754061 aaaaataaga tcgattgggg cccggtgaat cagccgattt cagaagaagc gtttgagcgg 2754121 ctgtacacga aagttgtcag ctatttaaag gagcgagatg aactgtttgt tttcgaagga 2754181 tttgccggag cagacgagaa atacaggctg ccgatcactg tcgtaaatga gttcgcatgg 2754241 cacaatttat ttgcgcggca gctgtttatc cgtccggaag gaaatgataa gaaaacagtt 2754301 gagcagccgt tcaccattct ttctgctccg catttcaaag cggatccaaa aacagacggc 2754361 actcattccg aaacgtttat tattgtctct ttcgaaaagc ggacaatttt aatcggcgga 2754421 actgagtatg ccggtgaaat gaagaagtcc attttctcca ttatgaattt cctgctgcct 2754481 gaaagagata ttttatctat gcactgctcc gccaatgtcg gtgaaaaagg cgatgtcgcc 2754541 cttttcttcg gactgtcagg aacaggaaag accaccctgt cggcagatgc tgaccgcaag 2754601 ctgatcggtg acgatgaaca tggctggtct gatacaggcg tctttaatat tgaaggcgga 2754661 tgctacgcta agtgtattca tttaagcgag gaaaaggagc cgcaaatctt taacgcgatc 2754721 cgcttcgggt ctgttctcga aaatgtcgtt gtggatgaag atacacgcga agccaattat 2754781 gatgattcct tctatactga aaacacgcgg gcagcttacc cgattcatat gattaataac 2754841 atcgtgactc caagcatggc cggccatccg tcagccattg tatttttgac ggctgatgcc 2754901 ttcggagtcc tgccgccgat cagcaaacta acgaaggagc aggcgatgta ccattttttg 2754961 agcggttaca cgagtaagct tgccggaacc gaacgtggtg tcacgtctcc tgaaacgacg 2755021 ttttctacat gcttcggctc accgttcctg ccgcttcctg ctcacgtcta tgctgaaatg 2755081 ctcggcaaaa agatcgatga acacggcgca gacgttttct tagtcaatac cggatggacc 2755141 gggggcggct acggcacagg cgaacgaatg aagctttctt acactagagc aatggtcaaa 2755201 gcagcgattg aaggcaaatt agaggatgct gaaatgataa ctgacgatat tttcggcctg 2755261 cacattccgg cccatgttcc tggcgttcct gatcatatcc ttcagcctga aaacacgtgg 2755321 accaacaagg aagaatacaa agaaaaagca gtctaccttg caaatgaatt caaagagaac 2755381 tttaaaaagt tcgcacatac cgatgccatc gcccaggcag gcggccctct cgtataaaaa 2755441 acaaaagcca agagcaatta tgctcttggc ttgttttaat tgacggaatg caaagaagtc 2755501 agcttgtatg taatgatggt ccggccttct tcccattgaa gcttctgcac ttcagctgtg 2755561 cctgactttt cgccaaactt tgttttgcgt acatccattg gaatctccat cggatatact 2755621 cggtatccgt ccttctctaa cgtgaatata ttttcatcta tgcgaacttc ttttcctttt 2755681 gtcacaatca gtgtattaaa ttcaacaggc attcccaaag tgaaatcccc tttcgttctc 2755741 ttttttcttt atcataacat atttcactgt cagcggtttt tcatccattg tgtgagctgc 2755801 cgcacgatac gccggttttc ttttggcggg aaataatgtg tgaatgtact gtagtaccat 2755861 gtttccaccg gcttatgcag ttgttttagc ttctcttcta ataaatagga atgctgaatc 2755921 gaaacatttt ggtctttttc tccatggatt aacagcacgg gagcctgaat tttgtttact 2755981 tggtcaaacg gtgtcctcca ttgatattcc tcaggcacct ttttcggtgt tccgccgatg 2756041 actcttttca tcattcgccg caaatcctgc cgctcctcgt atgtaagaat catatcactg 2756101 acgcctcccc aggaaacaaa tgaagctgcc tgcccgccca tttcgatcgc agtgagcatt 2756161 cccataattc cgccgcggga aaaaccgaag atatggattc tatccttctt gacatttggg 2756221 tgctgctgaa gcaggcgaaa agcagaaaat gcatcctccc tgtcttctcc ggcaaaatcc 2756281 tcattgcctt ctcctccttg attgcctctg taaaaaggag caaacaccac aaacccttgg 2756341 gatgcaaact ggataatccg gcccggccga accatgccca cgcttttaat cccgccgcgc 2756401 aaatataaaa atccgtcata ttgtcccggt tccgccggct cagccagaag ccccttaacc 2756461 cgtaatccat ttgacagata gcagatcgta tacaaacgca catgctggct tggcgacgga 2756521 aatcttcttt tctctacaat caaaacagcc gcctcctttt ttctatatgc tttccttact 2756581 ccaaaattac atccggagaa cctggttagg cattcacaca tttttatacc catcatacga 2756641 tatgtaaagc aaaaaaggat attaacttga tgcgaaataa ggaggttgtc tatgtgaaca 2756701 gatggttaag gctgggcttc gcctgtgtcg gcagtatctt tctgatgttc gccctggcgg 2756761 cttgcaagca ggaagaaacg ctcaccaaag tcaaagtagc tgaagtgacc cattcaattt 2756821 tttacgcacc tttatatgtt gctgagtcta aaggtttttt taaggaagaa gggcttgatg 2756881 tcgatgtgaa tacgacctgg ggcggagata aaacgatgac atcgcttctt tccaacggct 2756941 ccgacatcgc gcttgtcggg tcagaaacat ctatttatgt cgaagcgcaa ggggctaaag 2757001 atcccgtcat taatttcgcc cagctgactc agacagacgg aacgtttctt gtcgcgagag 2757061 aagatgttga acacttcgac tgggatcagc tgaaaggaaa aacgtttctc ggtcagcgaa 2757121 aaggcggcat gccgcaaatg gtcggcgagt atgtactgaa caaacataag attgacccgc 2757181 ataaggatat agacctcatc cagaacatag acttcgccaa tattgccaat gcgtttgctt 2757241 ctggaaccgg tgagtatgta cagctctttg aaccgcaggc ttctctcttt gagaaaaaag 2757301 gcatcggcca tatcgtggct tcattcggag aagaatcagg agaggttcct tatacgactt 2757361 ttatggcgaa acaaagctat ttgaagaaaa atgaagacac agccgtcaag tttacaaaag 2757421 ccatttataa ggcgcagcag tgggttgaaa atcattctgc gaaggacatc acagatgcca 2757481 ttaaagatga atttgatgat accgacccag acgtcatcga aacatccatt gaacgctata 2757541 aaaaacagca ttcatattca ccagaccctc tgcttaacga aaaagaatgg gagcttctcc 2757601 aaaccattat ggataaatcg ggagaactgc cgaagcacat tccatacaat cagcttgtaa 2757661 ataaagaaat tgctgaaaaa gtcacctcgg agaaatagga ggcgccatct atgtctttct 2757721 tacatgtcga ccatgtaacc catacttatt tttctattaa agaaaaaaca acggctgtgc 2757781 gggatattca tttcgatgcc gaaaaaggcg atttcatctc atttctcggc ccaagcggct 2757841 gcggaaaaac aacattgctt tccattattg ccggtttgat tgagccatca gaaggcagag 2757901 ttctgattga aggccgtgag ccgaatcaaa aagaacataa tattggctat atgcttcagc 2757961 aggattactt atttccctgg aaatctatcg aggaaaatgt gcttctcggt ttaaaaatcg 2758021 ccgacacgct gacagaagaa agcaaagccg ctgcactcgg tctattgccg gagttcggcc 2758081 tcatagatgt ggagaaaaaa tatccgaaag aactgtcagg cgggatgcgc cagcgggctg 2758141 cgcttgcaag aacacttgcg cctaacccta gtctgctttt gctggatgag ccattttccg 2758201 cgcttgattt tcagacaaag ctgtctttgg aaaacctggt attccgcaca ttaaaggaat 2758261 atcaaaaaac agcagtgctt gtcactcatg atatagggga agcgatagcg atgagcgata 2758321 cgatcttttt attttcaaat cagccgggca ccatccatca gatttttacc attcctaagg 2758381 aattggccgc gatgttgcct tttgacgccc gtcaggaacc ttccttccag acactgtttc 2758441 aaacgatatg gaaggagctg aattctcttg agaaacagca aagaaaccat tgatctgctt 2758501 cacgagcagt atcaattcaa acagaaaaag gaaaagtgga aggtccattc ctttcagctt 2758561 gccatattta ttctcttttt ctcgggctgg gaaatctcca gcaggcaggg ctggatcgat 2758621 ccgctgatct tcagctctcc atcagctgtg tggcgattat tgctggagaa acttggtgac 2758681 ggttctttac tgtcacacat cggcgtcact ttatttgaaa cggtgcttgg ctttttgctc 2758741 gggacgttta tgggcacgtg cctagccgct ttgttatggt ggtctaaccg acttgccaga 2758801 attttagatc cgtatcttgt gattttgaac gcaatgccga aagtggccct gggcccgatc 2758861 ctgattgtcg cgctcggtcc cagttttatc agcatcattg cgatgggagc catcatcagc 2758921 gtcattatca caaccatcgt tgtctacacc gccttccaag aggtcgacga aaactatacg 2758981 aaagtcatga aaacattcgg cgcaaaaaag tgggttattt ttaaagaagt catactgcct 2759041 gcatcctccc ccgcgattat ttcaacacta aaagtgaacg tcggtttatc atgggttggc 2759101 gttattgtag gggaattcct cgtttcgaag gtcggattag gatatatgat tatttacgga 2759161 ttccaagtct tcaattttac actcgtcttc ttaagcctgc tgatcatcgc catcttcgcc 2759221 actctgatgt atcagggcgt cgagctgctg gaaaagaaat ggacgaaggg gaggacataa 2759281 aaaacccggc acatgtgccg ggttttttat tcaatccatc cagattcttt cagttttttc 2759341 aagctgatcg gaagaacgga atccttcata ataaagctga attttttatt gcgggaaagg 2759401 ttctccggca gctcgtgaaa caaaaccggg cctttcgttt caaagtaatc agcctgcttt 2759461 tcaagctttt ctatatctgc aaaatatata ttttttacaa tcactttttc ttttccgaga 2759521 actttatact gtccgagata cttgaggctt ttgactctcg cgcccgtctc ttcctttact 2759581 tcccggagcg cagcctcttc tgcgcactcc atcggctcta ctttcccgcc tggaaactca 2759641 tagcctctgt cctcatgttc tgttaaaagc catttgccgc caaaacggca aatcacccag 2759701 acatgcttcg ggctgtccga gaaaggctga tcgtcaaagg aaagctgaac agtattctga 2759761 taataatctt taaactcgta catgtttatc cctcaaatcc gttcctagct atcttccata 2759821 catcatacca cagttacgtt tcttcggaag ccttttatca aaaaataagg gaaacccagc 2759881 acgccgtcag gttctgcatg cagactagct cgtacagttt ttttgcgata cttttgccgg 2759941 aaagtgcgac cgacgctctg ggctttatta tgacccgcga acagggaaaa gttacggttt 2760001 gcgcttaaat ttatttttta acgtttctaa aagatcgaca agcatctgag gaaccggtat 2760061 gccaagagag ctggctgtca caacaatttg cacagattca taaagaatat aaaacataat 2760121 agccaagtca cgaattgatc cctgtgtatt cagcagctga tcaaaaaagt ggcatacaga 2760181 gatcagagcc agcgtgacta attttttgac aagccgggca aatacctttt taaatgacag 2760241 tttgtgaata atggtttcct tcaaagtcgt actgataaat tcaattgcca taagagagag 2760301 caaaatcaga aatgaatact gaaaacctcc aaagaaaaaa cccgctgctg aaacgctgac 2760361 tgctaaaaac gaaaagatgc caaagtctct atccatttat cccaacatcc tttcacagaa 2760421 acggccttac gatattctat ggtaaacaag ccgaacggat tggatttttc agaaaaatgg 2760481 actggttgtc gcctattttt cagatacaaa aagaaaagcc ggacgtcttt tttaagacat 2760541 ccggccgttc tatttttgaa cttaacctag gtaagctttt agcatccagt tatgtttttc 2760601 aatattttga tggatcgcaa gaagcatgtc ccctgttgtt tcgtcaccga cttcatcagc 2760661 taaatccatg ccgtttttca gctcttccgc gatgactgtg aaatcatcat atacgctttg 2760721 aaccatttgt tcagctgttt catttccagc agcttctttg acagaagccg tttctaagga 2760781 ttccttcatt gttgcaatcg gttttccgtt cagcgccaaa agacgttctg ctaagtcatc 2760841 aatataagtt gctgtttcgt tgtacagctc ctcaaacttt tcatgaagag tgaagaaatc 2760901 tttccctttc acataccagt gataattatg tagtttcaca tacatgaccg tccagttggc 2760961 tacttgtttg ttcactgctt gaatcaattg ttctgacatg gtatctcctc cttgttatat 2761021 gactatgtat acccttaata tcgtacgcta aaacctcttt tttaccctta tctgtcacga 2761081 tttcttctat tatgctacaa ttgttaaaaa acgggaggtg gaatgtcatg acgcttctca 2761141 ttacgataag tattttgatt gtgctggctg ttttgcttgt aaccatttgg acgactgtaa 2761201 aagcctataa tgtaaagcat accattgatc caccacaaga aaatcactct gattcacaca 2761261 atcaatgatg atgtgaatgc tcctcttctg actgattgct ggcagcatcg gcgtctccga 2761321 cttggacttt taaggtcggc atgctatgct gtttttttgc tgtgacatga gattggacag 2761381 tgtatacacc atcttcctta aacgtcgttt ccaatcggta tacgcctttt tcttgtttca 2761441 ccttaaacat ttggcttgcg tctttttccc cttctttcca tacttcaaac tctacttcat 2761501 cggcatccgt cacagcttca tcaccatatg atacagctgc ttcataagca gcgctttctc 2761561 cgggatttac tttttcaggc ccggtcagct tgacatccaa aacctcgggc gtctcagctg 2761621 tatttgcttt actttcacca gatccgcatc cattaagcaa taaagcagaa aaaagcagaa 2761681 caaccaacat ctttttcatg ccatcaccct ttcatcgttt acctaaatag tagcaaacgc 2761741 ttacagcaaa tggtacacaa aatatgagac gtcacaaaaa agaccttttt gcttaagcgc 2761801 aaaaaggtcc tttctatttt agccaaatac ttttagcaat tcttctttat cctgtgaaag 2761861 ccagaaacgc attaaacgtt tagcgccttc cagatcatga agcttcgctt ggccgcactg 2761921 cttttcattc gcagcaggta tttctgtaat ctctaccgct tccttcattg tgtcttcaag 2761981 cagatcaacg atttccgctg atgtcggctc tccgctcaca actagataat agcctgtctg 2762041 gcagcccatt ggagaaatat caatgatatc aaaatgatcg tatttctcag cgtgagaacg 2762101 aatcgtaaac gcgagcaaat gctcgagtgt gtgaatggtg tcaggcttca tcgcctgttt 2762161 atttggctgg caaaaacgaa tgtcaaattt atttacaacg ccgtctgttc ccactttatg 2762221 cacgccgcaa tgtcttacat atggagcaac aaccgcatta tgatcaagct caaaactttc 2762281 tactgaaggc ataatggcac tctccccttt tttaaaaatg taatttcatt ataacatact 2762341 tttccgataa gaattattga ttaacttttc aatctgtgtt ttttttctta tacttgcatc 2762401 agaaaggttg ctgaagaaac atgaaaaccc tattcatcgc tctgatcaga ggatatcaaa 2762461 aattcatctc gcccctgaca ccgccaacgt gccgctttta tccgacctgt tcccaatatg 2762521 gaatcgaagc gattaaaaca catggcgctt taaaaggcgg atggctgaca atcaaacgga 2762581 ttttgaaatg ccacccgttc catccgggag gagtcgatcc cgttcctgaa aagaaacaaa 2762641 aacattaatt gttataaccg tttacgataa gatccagttt tccggtttta ggatcaatga 2762701 ctaagccatg gaccggaacg ttttcaggga acagcgggtg atgtttaata acatctacgc 2762761 tgtctttcac actcgcttcc actgaatcaa agcttttaaa ccattgatca aagtctacac 2762821 cggagtactt tattgtttcg atgcgttctt ccggaatccc tcttgctttg attttttcaa 2762881 gcatgctttt gctgctgatt ttgctcatgc cgcaatcgtg atgcccgatc acacacacct 2762941 catctgcatt cagctcgtac actgcgacga gtatacttct catgatgctt ccgaatgggt 2763001 gtgtcacaag cgcaccggca cttttaatga ttttcacatc accgtttcgc aaattcatcg 2763061 catgcggcag cagttcaacc agacgagtat ccatgcaaga aagaatcgcc atttttttat 2763121 ctggaaattt tgatgtttga tacttttcat actctctttg ttcagtaaat gtcttgttaa 2763181 attcgagaat atcatttaga agactcatgt tcgttgtccc tttctattct ttttactctt 2763241 caatatatca caacccttgt ttattcgtca taataaaaaa agacaaaccc tcaggcctgc 2763301 cttatttccc catgttatag cgttttttga actgctcaac tcgtccgcct ttttcattga 2763361 atttctggcg gcctgtataa aacggatgcg tgtcagagct tacctctact ttaatgacag 2763421 gatatgtgtt tccgtcctcc cactctgctg tttcattaga tgttttcgta gaggtgctta 2763481 gaaaacggta gccgctgttg acatcctgaa atatcacttt gtggttcttt ggatgaattc 2763541 cttctttcat gggtatctcc tttcaataaa tcgtaataat tacgttttat tttataacct 2763601 tacaaacgtt ttgtcaatct tcttatatcc ttccctctgt ttcacatcgt aaacctcatg 2763661 gcatttaaga ataggaagaa taatctaacc gaggaagcaa ataataaacc caaaatacat 2763721 acagaacgtc tttttggaaa ggtggtttac gattgtggat gatttagttt tggccagaag 2763781 cctttttggc acgacgatgg gctttcatat cattttcgca acacttggag tcggtctgcc 2763841 gctcatgatt ttagtggcgg aattgatcta tcaaaaaacg aaagatgacc attatgcgat 2763901 catggcgaaa agatggacga aagcacaagc cgttttgctg ggggtcgcca taccgaccgg 2763961 aacgatcgcg ggcactcagc tcgcgctttt atggccggga tttatggaag tcatcggccg 2764021 ggtgatgtcc ctgccatttc aaattgaaat ctatgctttt tttgttgaag ccctattcat 2764081 gtcgatttat gtatacgctg cagaccgttt gtcacctgca atgaggattg ttgctgtttt 2764141 ctttgtgtta gtcggggcag cagcatccgc tgttctgatc acgaatgttc acgcttttga 2764201 aggtacgccc gccggtttta aaattttaaa cggaaaaatt acagatgttg acccgtgggc 2764261 tgcgtttttt aatcctagct tttttatcac tgccggccat gtcgtgctgt ccgcgtttat 2764321 gactggtgcg tttatcgtgg cttctgttgc ggcgtataaa atgatccgaa cgaggaaaaa 2764381 ggaaagggtc tatcgctttc accggaaagc ccttttgctc gcactgacga tcggcggtat 2764441 tttttcattg ctgaccgctt tgaacggaca cgaatctgca cagatgctgt acgaatacca 2764501 gcccgaaaaa ttagccggtg cggaaggcct atttgaaaca agatcccacg ccccgctcgc 2764561 tatcggcggt tttaccgacc cgaatgaaga aaaagtaaaa tgggcaatcg agattccatg 2764621 ggctttaagc tttttggcag cgaaccgttt tgacactgtt gtaaaaggat taaatgcatt 2764681 tccgagagat gaatggccgc cgcttttcat tcacacgctg tttaatgcga tggttggtgt 2764741 aggcatgctg ctaattcttt attccattat cggtgtggtc tggagaaagg tgctcaagaa 2764801 agaccgtttc ccaacgtggc ttttgatcat tttcatgaca gcaggccctt ttagtctcat 2764861 cggcattgaa ttcggctgga ttttcgcatg tacggggagg cagccttggg tcatctatca 2764921 tctgctgaaa acgtcagatg tcgtaacaac gactggctcg atcggggtgc tgttcttatt 2764981 tttcacattt gtttatgccg tgttaggcgc agctgtcgtc tacgtgctgc tgtattattt 2765041 ccgcaagcac ccggttgacg aagatttaaa tacagcggag tcgtaatggc tccgcaaaca 2765101 ggaaaccaaa tggaaggaag atcgtacaaa tggagatttc aactgacgct ctgatcgcca 2765161 tctcaattat ctggggcttt gtgtttattt acgccgtcat ggcgacaatg gattttggag 2765221 cgggattttg gtctatgatc tatttaaaca aggagcatat gaaggccacc gatattgcga 2765281 atcgcttttt gtccccgact tgggaggtca caaacgtctt tattgtggcc atcgtcgtgg 2765341 cgcttttcag ttttttcccc ggcgcgacat ttgtgctcgg caccgtttta ttaattcccg 2765401 gaagcatgat tttgctgctt ttagcaattc gaagcggatt tctcgtgttt tcaaatacag 2765461 caaaggagcg gaaaacgcta agatatattt ccggcatctc cggctttatc attcctgcta 2765521 ttttaatttt ggtgcttcct gtgacacacg gagggtttat agaaaaaacg gatggaatct 2765581 ataacttaaa tatgtctaaa atcttttcaa gccccaacgc ctattcattt atcgggtttg 2765641 cgattttaag caccttattt ttgtcctcgc tgttgcttgc agatttttca aatgtggcag 2765701 aggaacagga tgcgtaccga gcctacagaa aaagcgccct gattaccggc ccgatttcac 2765761 tgttgtttgc tgtatgcatt atggtaacta tgcggaatga agcaaactgg ctgtacagcg 2765821 gaatgatgaa tgatttttct tggattattg catcgttcat tacatttgtc attgctggaa 2765881 tcgctctttt tctgcctaac aaaagctttg gtcaaaacat cggaaaaccg cgtctcgcac 2765941 ttgttgcgat tgggatacag tattttctcg caagctacgc gtacgggcgg gcgcatcttc 2766001 cgtatatgat ttatcccgat gtgacagtca tgtcaggctt cacagagcca gcaacgttca 2766061 gagcgctgtt tgcaacgtat atcgttgcat ttatcattct atttccgggc ttctttttct 2766121 tctggaaaat gtttatgcga gataaacgct atatccgcca ggaggaatag agggcaagcc 2766181 agccggctat actaatccag aacctttata aggaggggat ggcatggagc agaaaattct 2766241 atgtgaggtc aacaactgtt cttattgggg caaaggtaac aaatgcaccg ctgatgccat 2766301 ttatgttgtc agccatactg gtgaaacggc tgaaaacagc cgggaaacag actgcaaaac 2766361 gtttaagccg catgatttat aattaaaaga aagagctgca tcagccagct ctttcttttt 2766421 gcatgttgag tgttctcagc tttttagtta tgaccccgtt tgcaggtgaa aacaaaaagg 2766481 cgcttgcata acatacacct gtcatggccg ccatcgctcc tgaaatcgaa acattaagcc 2766541 acgttgcgaa gaaatagccc atgaccgccg acagcccgcc aatcaacgcg ctgagaatca 2766601 gcatataaag aagccggtct gtcagcaaat gtgccgcagc cggcggaaca atcagcatgg 2766661 ccacaaccaa tacggcaccc accgaatcaa aggaagcaac agtcgtcaag gacagcatgc 2766721 ccatttgcac gtaatgaatg agcaaaaccg gtattcccaa ggctaaagcc atttgaggat 2766781 caaacgaagc gattttaaac tccttatagc acacactgat caacactacg tttaaaacca 2766841 gaacagatgc cagcatccaa aacgctttcg gcccaatatc aaccccgaat accgtcaccg 2766901 tattccacgg cacaaaagcg atttctccca ttaacgagtg ctcaatatcg agatggacat 2766961 tcgctccata cacagaaagc aaaataaccc cgattgcaaa taaggatgta aacacaactc 2767021 ctatggcagc atctgattga acccccttgc tatgaagaag ctgaaccaag aaagccgtta 2767081 acagaccggt tgcggctgcg ccaataaaca tataaatccc atcgagactt cccgtcacta 2767141 gaaaagcgcc gacaatgcca agcaacactg tgtgactgat tgcgtcggcc agcatcgcca 2767201 tgcttctcag cacaagaaat gtgccgatca atccgcagct tacaccgact aatacaccgg 2767261 tagctataat ccatgcttca aaactcattt gcgatctgtc ccttctcggc atcatgagac 2767321 gcttttcgac gctcaggcat ccgtccatac agctttaaga gtgaataaag ccgctctctc 2767381 gtttctctcg gtaaacggtc cgggtcaaag tagtcctgat cggattctat attggcaagt 2767441 tccatttcat gcatgagata cacttcatac atccgctgct tcaaagctgt gtgatagcct 2767501 ttttctatcc ctttgcttgt gatttgccaa atcccatttt cgatacgctc aatgcacctc 2767561 tcttgttcca agtcatttaa tgccttaagg cataatgaag gggataggcg tcttttcttt 2767621 cttacacttt caacagttac acaaagatta ttcttttcat actgttcata aatcgccaaa 2767681 agcacttgct ccctgcttgt tctgcgccgc agcctcatca gccttatggc tttagcagcc 2767741 aatccccgct taggcgcgca aatcattgaa aaaagaaaga gcagcgttgc agataagatc 2767801 attaatggcc ctgtcgccat tcccttcatc gtggtgctaa gcagggttcc ggccactccg 2767861 ctgaccccgc ctgtaatccc ggcaatgatg atcatcccgg ttaatcgttc ggtccaatat 2767921 ctcgcggtta tggcaggtgt aatcagcata gccgccatta atatcacacc aacagtctga 2767981 agcccaatga cgacagcaca gacaatcaga caagccaaaa gcccgtttaa aaaacgcacc 2768041 gggattccta atccctttgc aaacgcgaga tcaaaagtaa tcaatgtaaa ttccttaaag 2768101 aaaacaatac ataggagcag tagaacagcg gatatccctg caataaggat gatatcctgc 2768161 ctgaccaatg aagcagcctg gccgaataaa aaagaatcaa gcccgctttg gcttcccgcc 2768221 ccctgttgct gaatatatgt cagcagaatg atcccgacgc caaaaaacac agaaagaaca 2768281 atcccgatcg ccgagtcctc ctttgttttt gaaagccgag gaatcagctg aatacaaaac 2768341 gttccgagca gtccggcgag cgctgccccc agcaaaaaga aaggcagtga tttttgcccg 2768401 gtgaacagaa aagcgagaca cactcccggc agagctgaat gggccatcgc atcgccgatt 2768461 aaactttgct ttctcagcag cacaaagctg cccaaaacac cgcttgccgt cccgagcaaa 2768521 agcgtaccgg ccagcaccca ctgtgtattc ggatgctgaa gctgcagcca caaactttca 2768581 aacattgcgc tcactcctta tgtccttctg ccagcacttt atcttttaaa aacgtaagcc 2768641 ttcctccata tgttttttgc aggttttcga tcgtaaaaac gttttccgtc ggtccgaaag 2768701 cgattttcct taaatgaagc agtaagatcc aatcgaaata atcctcggcg gtctgcagat 2768761 catgatggac gacaagcacg gtttttcctt tttctttgag ttctgccaac agcgtcataa 2768821 tcgcgcgctc cgtcgctgca tcaacacctg caaacggttc atccataaaa taaatgtcag 2768881 cgttctggca gagtgcccgg gcaagaaaca cccgctgctg ctgtccgcct gacagctggc 2768941 tgatttgcct tttcgcataa tcatgcatcc cgacttttgt taatgcggcc ttcgccatct 2769001 ccacatccgc tttctttggc ctctttaata aaccgattct cccgtatctt cccattagga 2769061 cgacatcgag cgggcttgtg gggaaatccc agtcaaccga gccgcgctgc ggaacatatc 2769121 cgattctggt ccgctgatcc ttatagtctt tgccgtaaat agagatgtct ccggaagctc 2769181 tgggcacaag accgagaatc gttttgatca aggttgattt tcccgcgccg tttgggccga 2769241 taatgccaat aagttttcct tcaggcacct gcagcgaaat gtcctgcagt acaggctttt 2769301 tatgataagc aaccgtcaca ttatcaagct caacagggaa catatcctcc acctcttttc 2769361 tttatttaag cgctttagta atcgtgttga tattgtggcg gaacattcct tcgtatgtgc 2769421 cttcttttgt gcccttttca cccatggcat ccgaataaag ctgaccgccg attgtgactg 2769481 tatggccttt ttctttagcg ccttccacca ctgcattgat tgatttttca gatacactgc 2769541 tttctacgaa cacagctttt atttgttttt ctgtcagaag atcaaccagc tcctgaacat 2769601 cccttaatcc atagtccgaa tctgtgctga gtccctgcag gccttttacc ttaaatccat 2769661 actcattccc aaagtacgca aacgcatcat gagcagtcac aagcacacgg cttttctccg 2769721 gaatatgtgc gatctcctta cgcgaccact tatctaaata ttgcaaatct tctttgtact 2769781 ctttggcatt tttccgaaag gcatctgcgt gctgaggcat tgctttgctg aattgcgctt 2769841 caatttcatc caccgcatag atccataacg gaatgctgaa ccagacgtgg ggatcaaacg 2769901 tcttgccttc ccccgcggga ataagcttat ttttcggaat ggcctcagct actgccgccg 2769961 attgtttttg ttcgccgatt ttttggagga catcctccat tttcccttcc aaatgcaacc 2770021 cgctgtacag aacaacatcg gcagacatta attttttcgt gtcaccttgg gaagctttgt 2770081 aaaggtgcgg atcaaccccc ggtcccatta aagaggtgac ttttacgtgc ttacctccga 2770141 tgttttctgc tgcatcggca atttgagatg ttgtcgctgt cacttgtaat tgctgatcag 2770201 cgctttttcc ggctgaatcc gttccgcatc ccgttaaagc aaaggtcgca aaaagtactg 2770261 ctgccatcag cccttgtctc atatttctcc tcctctttgc catcaatgtc cgattgtttt 2770321 atcttatgtt gtcagttctt agacatgtga cattaaatta gccaaaagca tgttttattt 2770381 acacaggaca aaaagtttcc ctcatgcaaa attatcgcgt ttggccattt ttgtcaagct 2770441 gatttacata aaaaaaccgg ctgggtcagc agccggtcca aacgagaagg gatgtattca 2770501 acgaacactt ttactgtaac agcacagtgt catttattca aaatagcaaa atgctttttt 2770561 cttaaccatg ctgtgtgaaa acatccattt tggtcacata ttttcgcata atatcttggt 2770621 ttacctcaac ccctaaacca ggctgttttg acacagaaat aaatccatta tcaatacgaa 2770681 tatcaggagt tacaatatct tcatcccaat agcgtgagga tgaagatata tcgccaggta 2770741 ttgtgaattg aggcagtgaa gcaagcgcca cgttctgcgc tcttgatatg cctgtttcca 2770801 gcattcctcc gcaccaaacc tgcatatgat gctctttgca taaatcatga atttttaagg 2770861 cttctgttaa gccgccgaca cgagaaggtt ttatattaat aattttgcag cttcctagct 2770921 caatcgcccg tctcgcatca tcaactgaac aaatgctctc atcaaggcaa atggccgttt 2770981 tcaaatgttt ctgcaagtgg cggtggtcaa cgatatcgtc agcttggagc ggctgctcaa 2771041 tcatcattaa atgatagtca tcaagctcct ttaaacggct gatatccttc agttcgtaag 2771101 aggaattggc atcggccata agcgggatgg ttgggaatcg gctgcggatg gccttgacca 2771161 attccacatc ctgcccaggc tgaattttaa tttttattct ttgataacct tctttttgat 2771221 agctctcaat ttccttcagc atatcgtcaa gaggcgccag gccgactacc accccggcag 2771281 ggactttatc tcttgttccg cccaatgcct cagcaaggga tacgcccttc tttttggcat 2771341 aaatatccca tacagccgat tcaagtcccg cttttgccat ccggtttcct ttataccgcg 2771401 ccaggctgtc cggcacttct gaagggtgat tgaattcacg gccgacgaca tttgggataa 2771461 aaaaatcttt tagcatatgc aaacatgttc caatggtttc ctcggtgtac caaggcgaag 2771521 agaaagcgga aacttctccc cagcctgtga cacctgatgt atcaatggct tccacgatca 2771581 gaaatttacg ctcttgaagc gtttcgatac tgtttttaaa cggtttcttt aagttcatgc 2771641 tcaaatggta aagcgtgatt ttttctattt cgatcatagc agttctcctt tacgcgcatc 2771701 cttcagctga tttcgcaaga gcttattaga cgcattgcgc ggcaggcggt caagcacaaa 2771761 gaattttgcc ggaattttat acttcgccaa gcgttctttg cagtagtcag tcaattctcc 2771821 tgcgctcaca ggcttgtgaa ggacaagata ggcgtgaggc actttccccc attttttgtc 2771881 ctcagcccct gaaaccccgg cttcggccac agcggggtgt gaaagcagca ctgactccac 2771941 ttcggccgga taaatgtttt ctccgccgga tatgatcaga tctgaacgtc tgtctaatac 2772001 atataaaaag ccttcattgt ccaaataacc aagatcacct gttttcagcc agccattttg 2772061 aaaggaggct tcgtttgcgc tctcccggtt aaaatagctt ttcatgacat tcgggccttt 2772121 gaccatgatt tcaccgtgtt catacggttc acatacctgt ccgtcccgct ctattttgat 2772181 ttcacacgaa aacagcggtt tccccgcaga tccgagcttt tccatgctga attccggcga 2772241 cagggtaaca atttgcgagc atgtttctgt cattccatat gactgaaaga cagggaatcc 2772301 tttctcacgg cattcctcaa gcaatggcag cggtgcagga ccgccgccga gaagaatgca 2772361 tctgatggat tcagggcagc ggtttgtttc ttccaaaaga ctggccagca tagtctgcac 2772421 cgcagatatc attgtcactt catgcctgtt gatagaatgc agcacatcgc ttacggaaaa 2772481 acgctggtga agcacgacag tcattccata gatcacagat ttaaataatg cggacaatcc 2772541 gctgatatga aagagcggca atgcgataag ccagcggtct tgttctgtta tacccaaatt 2772601 aagagcggac gacaccgcac tgaaataatg gtttccgaac gtttgctgaa ctcccttggg 2772661 ctttcctgtc gtacccgacg tatacatcag cgttgccgtt gcatccattt gcatataagc 2772721 ctcgatctca atttcctctg ctgcttcttt catcagttca tccacatcaa tcgtttgaac 2772781 gatgtgttca tattctttct tctcaaagct tgaatctgtc aataaaaagc cggatcccga 2772841 atcctccagc tgaaacagcc tttcatgtgt tgacagcttc gtattcaaaa gcaccgcctt 2772901 aacaccaagc aaaaaacaag cgtgaacagc gtataccatt tctgcacggt tttggagcaa 2772961 aatagctgca gtatcccctt tccgaaccga atgagcggca agctgttccg ccattcgttt 2773021 agacgcggca aacaattctg caaatgtcac ggtttggtct tcatagatga gagcgattct 2773081 ctcaggtgtc agctgtgccc gctgcatgag ccagttgggc tgttctgtca gcatgtcatc 2773141 atctccgagg taaaatgtct gtattgaaaa gaaaacagct tggaccgcaa agtctcaagc 2773201 tgttggttta ctagatattg ctgatcacgg aaaacgaggg aactgtccga aatcaggttt 2773261 gcgtttttcc ttaaaggaat cacggccttc ttttgcttca tctgttgtgt agtaaagaag 2773321 ggtagcatcc cctgcaaact gctgaattcc agcaagtccg tctgtgtccg cgttaaacgc 2773381 agctttaaga aagcgcagtg cggtcgggct tttttcaagc atttcttcac accatttaat 2773441 cgtttcttct tcaagctgtt ccaaaggaac gactgtgttg acaagaccca tgtccagtgc 2773501 ttcctgtgcg ttgtactgac ggcataggta ccagatttca cgtgcttttt tatgtcctac 2773561 aattcgagcc aggtagccag aaccgtaacc tgcatcgaag cttcccactt tagggcctgt 2773621 ttgtccaaaa attgcgttgt ccgcagcaat tgtcaagtca catacgatgt gaagcacatg 2773681 gcctccgccg atcgcatatc cggacaccat cgcaacaacc ggtttcggga tgacgcggat 2773741 taaacgctga agatccaata cgttaagacg agggatctgg tcgtctccta catatccacc 2773801 gtggccgcgc actttttggt ctccgccaga acaaaatgct ttgtcccctg caccggcaag 2773861 cacgataacc ccaacgtttt ggtcgtctct tgcgtcagca aacgcatcaa tcatttcagc 2773921 aaccgtttta ggggtaaacg cattatgtac ctcaggtcgg ttgattgtta tttttgcaat 2773981 gccattatac gtttcataca atatctcatc gtatgtccgt tttgttttcc attcagccat 2774041 atgatgacct ccttttattc tctatgtgaa tgagtcagat gcttgtcaaa aactcactca 2774101 ctattttacc aaacaatcgc ggctgctcca catggaccgt atgtcctgct tttggaacaa 2774161 tctctattct actagaagga agcatcttat gcacctcttg attgatggcg caaaattttt 2774221 cgtcccactc cccgcagatc agaagcacag gaacatctat ttcctctaca cggctccaca 2774281 aggaaggctg tgaaccggtg cccatgccgg ttaaactgtt cgcaagccca atcttattgt 2774341 tccgcagacg gcccgatcgt atcctgtacc gaatatcttc agccagcctc tgctgagatg 2774401 aaaacaaagg gatattctcc caatacgcaa caaacgcttc gagcccgtct cgtaaaataa 2774461 aatcagcaag cttccggtcc cgcatgattc gttcccgccg ttccccaagt gttttgagcc 2774521 ccggcgtcgt gctttcaagc acaagtgccg atacccgctc gggatatgtc atcgcaaaag 2774581 agtaagcaag ccttcctccc atagaatacc caatcaattt cactttgtga agttttaatt 2774641 gatcaaaaat ctcggcaagg tcagaaactt gccgggttgt gctgtatctt ttcccattca 2774701 gcggggcatc ggtttcccca tgccctaaac aatcaatttt gatcaaacgg gaatcaggca 2774761 gcatttcatc aagaaaagtc catgattgtt tgctgccggt aaacccatgc agacagacga 2774821 cggcttcgga agcattcggt ccctcgtctg ccactgcata tcggacacca tctgataccg 2774881 ttatgtttac agttcccatt gttttttcac ttcccgcaca gcctcattca gcatatcgcg 2774941 atgaagctgg actcttgatt ggcgatccgt tttgatttca atcaaatgga gtccgggctt 2775001 gtctgcctgc ggcgcgtaag ctgttttgaa ttcatcccaa gaagccgggc atgaatacgt 2775061 tccgccgtaa agtgcagccg catgcttgaa atcgagccct gtcggtgtgc cgaacaaatc 2775121 ttcaaagtgt gtcttctcag aagcctgcgg caaaaaggag aaaatccctc ctccgtcatt 2775181 attgacaaga atcacagtaa gaggaatacc cagctttttg gccgccagca ggccgtttaa 2775241 atcatgataa aaagataaat ctccaatcac aagggtaaca ggcgcttttg ttccttcaca 2775301 tacccccatg gcagaggaga cgacaccgtc tatcccgttt gctccccggt ttgaataaat 2775361 ccggaaaggg cggtcctgct tttcaaaaaa cgtatcaaca tccctgatcg gcatgctgtt 2775421 tcccacaaac agcgagctgt tttcaggcac aagatgctga aggattcgat agagattgcc 2775481 ttcaaacgaa acatcttcac tgctgattgt ttgcagatgc tcgcggaacc gcccattgac 2775541 aaactgccac ttttccagcc actctgagga tctggtggca gcagtaaggc ctgccatgat 2775601 ctcctcagca aaaacagacg cattacaatg aatcatatgc gcgcttgcct gtgtcgggtc 2775661 tctccaccct ccatcctcgt caatcacgat ttgctgaatc gtcggatcat ccttaagcca 2775721 taagaaaacc ggttttgaaa caggcatcgg tccaaaccga atgacaacat caggacggag 2775781 tttccgcttc agctcatcat cttttaaaaa cgaatcatac gcatcaataa cagtgctttt 2775841 atcatgaaca ccattccgca gattagacag cggatctgct aaaattggat actgaagcgc 2775901 ttttgacagc gcaataatgt tttccttgtc cgcatcacta tggagctctc cgcagacgat 2775961 cattcctttt tcagcctctg cgagcatctc agccacatca gacagggact ctcggtcaac 2776021 agactgcgta cccgttttca cagacacatg acggcctgtt ctcattcttc caaacggctc 2776081 atctgaaaga tccggcatca gcggttcgcg cagcggcaca ttcacatgga caggccccat 2776141 cgggcgcttt tgtgcttctc cggcagcgcg gcttgccagc gttcggatgt atctcagcat 2776201 ttgcggagac tcttcaggaa gagcagagtc tgtgaaaaac ttaacaaagt taccgaataa 2776261 gaagtgctga ttaatagcct gcggtgcgcc tacttcgcgc agctcatgag gccgatcagc 2776321 agttaacaca ataataggca cccttgaata atgggcttca accacagccg gataaaagtt 2776381 ggccgcggct gttccagatg tacagatcaa tagtacggga cgctgcttcg cttttgccaa 2776441 acctaatgca aaaaatccgg cagacctttc atcaatttgg acatggacgc tgatatcggg 2776501 atgcgcagca caaagaacag ccagcggtgt agatcttgag cccggacaaa cgacggcgtc 2776561 cgtaattccg gaaagggcga attcatcaat aaaacttccg atgtaatgag taatcgggtt 2776621 gactgtcaac gcctctcacc tcctaatgca gagatcatcg gcttcaattt aatctgtgtt 2776681 tcttcatatt ccgagattgg ttccgagtct tccacaatac cgcacccggc aaacagcctt 2776741 gctgtgcttc cttcgatgag ccctgaacga atggcgaccg cgaattcccc gttatcctgg 2776801 ctgtcaatcc agccgatagg ggccgcatac cagccgcggg acatcggttc aatctccctg 2776861 atcacgtcaa cagctttttc ctgaggtgat cccccaagcg cgggagtggg gtgcagcttc 2776921 tcaattaagt caaaaatcga agcagactcg cgcagctgtc cgacaatcgg cgtaaacagg 2776981 tgctgaacgc tttttgtttt gtacaaaaca ggtccatcag gcttttcaac ctctgaacag 2777041 cttgatacaa aagcattatg aatcatacct accacaatat catgctcaag caggtttttc 2777101 tcatcgttta ataattcaag gcctatccgg cggtcgtctt cttcattcac gcctcgttta 2777161 atggagcctg ccagacagga agacatgaca gtgccgccgt ctcttttgat cagtctttcc 2777221 ggagacgcgc cgacaaaggt tttgccttct tgttcaattg caaaaacata gcttgtctgc 2777281 tgatcgtcca gaagcgtttt aagcaccggt tcaatttgga ttggaccgtc aaacgtgagc 2777341 agcagctctc gggcaagaac aaccttatca tattgtttct ctttaatttg gcttgtggcc 2777401 gtttcgattg ctttcagcca atcatcctta tccagctctt cggctgctgc aatcacagcc 2777461 tgatcttctt gcttgaaatc gggaaccata aattccgccg caaaagcttt taagccttct 2777521 aaaacagctt ctgcgtcttc tcctccgctt acccatctgt taactgttaa gaacgggcct 2777581 tcagcagtca tcgtcagcat aagcgcaggc acaaagaaat ccccttccga gaaatggtcc 2777641 cattgtgaac ctctttcttc gcaagggtca aaagaaaatc ctccgaataa cacaggtccc 2777701 actgcagaat gctgcagctt ttcttcttca taaatatgaa aagccgtctt tttaaagcgc 2777761 tcccattgtt caaaaacctc acgataccgc tcgctgtttt tttgatttgt ctggaaaacc 2777821 gcttctttgc caagaccgac tattgtcaat tcactttcag gatctgacca aaaaaatcga 2777881 ttgcctgtat atttttttgc tccgtaattg aaaaatgata gagggtcaag agactcgatt 2777941 tgtctcgaat agcttattaa gacagcatgg ttgacttctt tggctttatg taatgcatgt 2778001 agaacttcct ttcggaacgt acgctgcacc gttgtcacca tgagacattc ctccataatc 2778061 cttaaaatgc ttttaatacc atacacctgt gtctcctttg tgtcaaacac agatcatgca 2778121 gtccaaatgg cctgccttac ctattataaa cctaatttca gaaatgaaaa agaaacaaag 2778181 cttaaatttc tttctccact gatagcaaag gttgtatccg cttaccataa aaggaaaacc 2778241 tcctatattc ctccacccgc catttatgaa agttctcagg cgatctgttc atactaaagg 2778301 tatgcatcac agagaaacga ggcgatcaca ttgcttacga aagaacagct tcagcattta 2778361 aaaaatgaac tggaacaaac gaaaaaagat atcttaaacc gtttcaaaga caatgatcat 2778421 tttcagctta actcagcctt tccttatgat tcgtggggtg agctttcggc atacgacaac 2778481 catcccggcg atcaggcgac agaactttac gagcgtgaga aagacatcgc tctagacttg 2778541 catgagagag agcaccttcg ggacattgag cattcattga aggcgataga aaacggtacg 2778601 tatggcattt gtgaagtcag cggaaaggaa atccctttcg aacgacttga agcgcttccg 2778661 actgccacaa ccctcgcgga gtattcgtca caggacgtgg tttccaaaga ccgtccgatt 2778721 gaagaagaaa caccattcgg gcaatttgaa tttgatgatg atgaagaaat cagagcgcca 2778781 tatgacagtg aggattccta tcaggatgtc gaaaaatatg ggaactcaca aacgccgcag 2778841 gatatggaaa accctccgct cagctatgat gatatgacga tgaatgccga agagaatatc 2778901 ggcaatacgg agtcttacga aaatttcatc gctacagata tcactgggaa agaaattacc 2778961 gtttatcaaa gcagagccca tgagcgctat gaagaagaac ttgacgaaga gggaatcatg 2779021 accacattcg gcgatctcca cgctgattga acccccaatt attgggggtt cttttccgtt 2779081 ttcagcatat cgtaaatcag cttcagataa tccttttgca ggccgatgtc ataccgctcg 2779141 ccctctagca atttcccgta tacggtacat gccccgagcg aagcttttat cgcatccgtt 2779201 acctgcactt ctcctccgct atcagcttct aatgcctcca gctcattaaa aatatccggt 2779261 gtgaaaatat aacgccctgc tgcggcaaaa tgagacggag ggttttgttt aggcttttcc 2779321 acaatatcct gtatgcgata aagccctttt tcaacaggct ccccttttat caccccgtaa 2779381 tgatgtaaat cctccgtttt tgtttctttt aagccgatca cactggactg atatttcgta 2779441 tacgcttcaa tcagctgccc caaagccggc tgattggcgg aaaaaatcag atcatctggc 2779501 aaaacgacgg caaaaggctc tcctcctgca aattgctttc cgaaagaaat ggcgtcgcca 2779561 agaccctttg cataaggctg ccgcacatag tgaatccgta tatccggaat gggatgctct 2779621 ctaagtaaat gcagtttatt cttagaggcc aaaaaagcct caagtgccaa agaggaatca 2779681 aaatagtcga caatcagatt tttatggctc gatacaacca tcaaaatgtc ctcaatgcct 2779741 gactccttta attcttcaac aagataatga atcacaggct tagatcctac cggaaacatt 2779801 tctttcggaa tcaccttcgt caccggcaga tttctcgtgc cgaatccgcc tgcaggaatg 2779861 atcgcttttt ttatcatggt attttcccct cagctcatgt ttattacatg atattccaag 2779921 agcgcatccc gatgtttgta catctgaaat taggcggaag caactgggca gaaagcggaa 2779981 tcacgaacca gccctttttt aataggatat tgatatatga ccagtaatct tgtaaaggag 2780041 ctcaggtgat gaaaatttgt gtggttggcg ccgggtatgt cggtttaacc ctatcagcgg 2780101 cactggcatc catcggacat gacatgatat gcacagacaa agacgtcaaa aaaatcgggc 2780161 agctgaaaaa aggagtcatt cccttttacg agcctgggct ttcagatgca atacttcgtt 2780221 gcggcaatct ctcgttttct tctgaagtga aatcgagcat ggaggaatgt cccgttattt 2780281 ttatcgcagt cggaactccg ccgcgttcgg acggatcagc tgatacgaaa gccctgcagt 2780341 ccgtcatcgg tgatttaagc gaggcgatcc gatcgtataa aaccattatt acgaaaagca 2780401 ctgttccgcc cgggacaaat gaaaacatag caaaacagct gattgcctcc ggagtgtcta 2780461 aaaacctctt taatatcgta tccaatccgg agtttctgcg ggaaggcaat gccttatatg 2780521 acatgctgca tcctgacaaa acagtcatcg gtgttcagga agaagatcac gtatcggcag 2780581 ccatcgtcaa atccatttac aaacacattg ataccccttt tatcgttaca agcttagcgg 2780641 gagcagagct gatcaaatat gccaacaatt tctttttagc ggccaaaatt tcgttcatta 2780701 acgaaatggc ccgcatatgt gaagcctatc aatcagatat ctcagatatt tcccgcgcta 2780761 tcggtctaga cccaaggatc gggaagcact ttttgcaggc aggcatcgga tacggaggct 2780821 cttgttttcc aaaggatctg caggcgctgc aatttgctgc ccaggaaaaa aacacggaga 2780881 ccttcctgct ccgggccgtg cagcacatta atgacaccca gcttggcctg tatatcaaaa 2780941 aaatacagtc attcttcgaa acacttcaag gcaagaaagc ggctgtactc ggcatttcct 2781001 tcaaaccgaa tactgatgac atccggaatt ctcaggctgt cagactgatg gaaaggctgg 2781061 cggagctggg atgtgatgtt catgcatatg atcctgaagc tgtacttcca gaacatttgc 2781121 ggcaacatgt aactcagcat tctcaagctt ttgatgcgat cgaagagagt gactttttat 2781181 ttttggcgac agaatggtct gagtttttag cgtttgattg gaaaaaggct gcagatatca 2781241 tgaaagggcg tcttgtgatt gacggacgca acgtactaaa aaaagaactg atcgaggctt 2781301 gcggcctgat ctgtacggga gttggccgtc catgaaaata ctcgtcacag gagcagcggg 2781361 ctttatcggc tcccacctct gcgaagaatt actaaaagat aagaaacata acgttatcgg 2781421 aatcgatgac tttatcggtc ctactccatt ttccttgaaa ttaaaaaacc ttaaaaacct 2781481 gctgccggaa aagcgattta cgttcataaa ggaaaatctg ctgacagccg atcttgcttc 2781541 cttactggaa ggagtggacg tcatctttca tttggcggcc ataccgggtg tccgctcaag 2781601 ctggggcaat cattttcacc catatgccgc acataatatc caagcgctcc aaaggctcct 2781661 cgaggcgtgc cgggaacatt ctattcaaac gttcgtcttt gcatccacct cttccgtcta 2781721 tggcgaaaaa caaggaaaag tcagcgaaaa cacgtcgctt tctcctttat ctccgtacgg 2781781 ggtaacaaag cttacgggag aaaagctttg ccatgtgtat aaacagagct ttggcattcc 2781841 aattgtgatt ctccgttttt ttaccgtata cgggccaaga cagcggccgg atatggcttt 2781901 tcaccggctc attaagcagc accttcagca aaagccgctt accatcttcg gtgatgggca 2781961 gcagtcaaga gatttcactt atatcagcga ctgtgtcaaa ggcatcaccg ctgttcttgg 2782021 gaaaccccac cttattggtg aaacagtaaa tatcggcggc gcagagcgtg cctcagtctt 2782081 aaaagttgtc tccctcattg aggatatttc cgggagaaaa gcaacactgc acttttcgga 2782141 caaaatagca ggggaaccga gcaacacgtg ggcggatatt tcaaaagcaa aacagctctt 2782201 gcattatgat cccgccacat ccttaaagga tggcttgacc aacgaaatcg cctatttatc 2782261 gtcgctgtat cagggggaat aaaaatgaag cttgccttta tctgtacaga aaagctgccg 2782321 gcgcccgcag tacgcggcgg cgctattcaa atgatgattg acggtgtcac gccctatttc 2782381 agcagcaggt acgacctgac cattttttca atagaagatc catcgctccc aaaaagagaa 2782441 acaaaagacg gcgtacatta tatccatctg ccaaaagaac attaccgcga ggcggtagcc 2782501 gaagagctgc gagcctcttc ctttgacctc attcatgtgt tcaacaggcc tttaaatgtc 2782561 tctttatata aaaaagcctc accaaacagc aagatcgttc tgagcctgca taacgaaatg 2782621 ttttctgaaa aaaagatgac cttcgcgcaa ggaaaagaag tactcgacaa tgtctccatg 2782681 atcacaacag tgagcgaatt tattaaacaa accgtcattg aacgtttccc tgaagccgag 2782741 gacatcacaa aagttgtgta ttccggcgtt gatttaaact cttatccgcc cgtctggacg 2782801 atgaaaggct cggctgtcag aaaaacatac cggaaaaaat acggtattga agataaaaaa 2782861 gttattttat tcgccggccg cttaagcccg acaaaagggc ctcaccttct cattcacagc 2782921 atgagacgga ttttgcagca gcaccctgat gctgtactgg tcatagcagg cgggaagtgg 2782981 ttcagcgatg acagcgaaaa ccaatatgtc acctatctgc gcacgctggc gctgccatac 2783041 agagaccaca taatctttac aaaattcatt cccgcagacg atatcccaaa cctttttctg 2783101 atggcagatg tatttgtgtg cagctctcag tggaacgaac ccctcgcccg tgtgaattat 2783161 gaagcaatgg cggccggcac gcccttaatt accacaaacc ggggcggaaa cggtgaagtc 2783221 gtaaaacacg aagtcaccgg ccttgtcatc gatagctaca acaaaccttc ttcatttgca 2783281 aaagcaattg acagagcctt tacagatcaa gaattaatga acaaaatgac aaaaaacgcc 2783341 cgaaagcatg tagaagcttt atttaccttt acccatgctg ccaaaaggct caatactgtt 2783401 taccaatccg ttctgacccc gaaaaacaaa caatttccgc cgccttttct gacgcaaaat 2783461 tttgatttat catctatcaa tcagcttttt gtgaaagcaa aaacataaaa cctacagctc 2783521 gtgttgcaaa acgggctgtt ttttcgctac agagaactta aaaaaaggca taaatgtgac 2783581 tttatgcctt gcgctttaca gtttgagaaa accatggagc tggtttagat tcacttggaa 2783641 gaatgatgat ttccacttta gcttcttccg ctaagtctgg ttcttcatct tcatcctctt 2783701 cttcatatgg gggcgctgag cgtttcgaat cacgctcctc ctcaggctcc agagtggttt 2783761 cgaattttgt ttcttcttca tcatcgacga ttttgcgatc tgtttccttt tccttcgttt 2783821 ctttttgata ttctttcggt gcattgatgt gagggagctc tcgaatgctg cccacatcta 2783881 aatgcttctc ctcttcttcc ttctcagctg agattgagtc atgagcctgc catcccatcg 2783941 gtccaggcgg tgtaaatacg aattggtcga gatccagttt agaaatagag gctttttgtc 2784001 tcgatgacct catgtcaatt cgcctcccga tacgctttta tctttttata cagttccggc 2784061 agtttatcca aaaacgaatc tttagattct tcaacagaaa tcatgttttg cagcgcccag 2784121 ttatacttct catctgacca cgttttcttt tgcttcaaat aatatttgtg cccgattgca 2784181 cagaacaaat gcggaaacgc gagatcaatc caaagtacct cgtactgttt ttctgtgagc 2784241 ggatacactg cgtcgtaggc cgcaagcagt gcaaccatga aatcagtatc ccatacagaa 2784301 agcttaacca tcactttatt cagcagaata cgaaggtctc ttgacggcaa atcgtaggta 2784361 atcgagtgaa gctcctttaa aaaaggctcc ccttcgatct cagtcaaacg tgccaatgta 2784421 aaatcctgaa aacagaatcc gccatgctcg agtgtctctt ttgtccaggt ttcgtattct 2784481 gagtcatcaa gcgctctgag agcttctttt cctcttgcca gcattttatc agcatgtttt 2784541 aagaaagttt gcgaaaatac gtcatcagga taggatgctg cgatctgcat attcccttca 2784601 agttcctgca gcttccaacg gtacaatttg tgccattttc ccagcctgct tctcttcttg 2784661 ctttcatctg tgcaaacata tccttttgag gcatgatgaa aatggccggc aaatgacatg 2784721 acttttttca tttgctctgc atcatagtaa atcatttctt ttcctgtcac tttgtcatat 2784781 aaactgtaag aaacctgatc cgtgcccaag cagctaccgc cattttttgt ttgatgaatc 2784841 ggcgctatcg gcagcccttt ctcttgtaaa tgggcgtgtg cctgagtgat aaaaagcatc 2784901 cgctccggtt tcatttgcgc ttcttttagc agctttgggc catgatcagt ttcgacttcc 2784961 cagattttgc gcccgctttt gttcgatttc agcgccacat ggtcgatatg aaacggataa 2785021 taactgagaa tttcggacac aatctgttct tcatgctctt tttggtacac tctgttcacc 2785081 ccttctatct gttcttttca tagacgctga gcagattttc agccaccctc tgccagccaa 2785141 aattgctttc tgcctcacgg cggctgtatt tcccaagccg ttcccgcttt tccgagctgc 2785201 tcagcaaatc attgatacgt tcggcatatt gtttaggatt ttcaaagtca tgaatgatgt 2785261 agccgttttt cccttcctct atgacctctg gattgcctcc ccgattgctt gtaataatag 2785321 gaagtcccgc agccatcgct tcataatgca cccttgctaa aggctcctgc cattgcgaag 2785381 agcatacaaa tacatctgac atggtataaa ggcgcggaat gtcctttggc ttcacaaatt 2785441 gaataaatgt gacatgatcc ttttgcatcg caccaagggt atgaagatgt ttgacatagt 2785501 tatttaattc attatctccg aaccattttg acccgataaa caccatcatg acatcggggt 2785561 gctcctcaat gatgtccggc aaagcctgca ataatatgtg cgggcctttg actttgctaa 2785621 gccggccgac aaacaagacg atttttttgc cgtgaagccc cagctcgctt cgcatctctt 2785681 cgcgagctcg ctgcccttca ttcgtccagc gagggtggta cgtttttaaa tccacaccag 2785741 aatacaccgt ttttgttttt gatcgtgctg acggaaaacg gcttgtgatc gtctgtccga 2785801 tataatcgct gaccgtaaca atctgcgcta cggagtcgat gcaaatctcg ccttccgcct 2785861 ggctgatttt atcgtaagcg aacatttcat tgtgaacgct taaaataaaa acagcatccg 2785921 gcgcctgttt cttcaatttc ggaacccagc ttgggcgatt acaaacatgc acaagatcaa 2785981 aacggctctt tttcagctct gctccaacgg cttcttcata acggtcttca tccaaatgca 2786041 cataatggac accgtctacc ttctctctat cagcgagatt cggatcttta atagaaaaca 2786101 cagtcacctc atgttttttt gcaattaaag gggcaaccgc ttcgaggtag atttgaatgg 2786161 cgcctcctcg aaccgatggg acaggaagct tctctgtggc gatcagtgct attttcatac 2786221 atagcctcca ttcctgcatg atttttaact agttagaatc atgatacggc tgaacaacca 2786281 acttgtgcgg aatgggactg ccctaaaaac aaaacgggta aacaaccaga ttcatctatt 2786341 aaatatagtc aaataactca atcatttttt ccttttgatt cataaggtag gagtaaaaca 2786401 ggtaaggatg tgtcctttaa tggcagaaaa ccatgaagtc attgaggagg ggaattcatc 2786461 agagcttcct ttatcagcag aagatgcaaa aaaattaacg gagctggctg aaaatgtgct 2786521 tcaaggatgg gatgtgcagg ctgaaaaaat agacgtcatt cagggaaacc agatggcgct 2786581 tgtctggaag gtccacacag actccggcgc ggtttgtcta aaacgaatac acaggccaga 2786641 aaagaaagcg ttgttttcca ttttcgcgca ggactattta gcaaaaaaag gcatgaatgt 2786701 tcctggcata ctcccaaaca aaaaaggcag cctatattct aagcacggct catttctatt 2786761 tgtcgtatat gactggatcg aaggaagacc gtttgagctg actgtaaagc aggacttgga 2786821 gtttatcatg aaaggccttg ctgattttca tacagcttcc gtcggatatc agccgccaaa 2786881 tggcgttccc atatttacca aattaggtcg ctggccgaat cactacacga aacgatgcaa 2786941 acagatggaa acgtggaagc tgatggcgga ggcggaaaaa gaagatcctt tctcacagct 2787001 ttatcttcag gagatagatg gctttattga agacgggctg cgcatcaaag accggctttt 2787061 gcaatcgacc tatgttccat ggactgaaca gctgaaaaaa agccctaacc tttgccacca 2787121 ggattacgga accgggaata cactcttagg agaaaatgaa cagatttggg tcatcgactt 2787181 agataccgta tcatttgatc tgcctattcg cgatttgcgc aaaatgatta ttccgctttt 2787241 ggatacgacg ggtgtttggg atgacgaaac atttaatgtc atgctgaacg catacgaatc 2787301 cagagcccca ttaactgaag aacaaaaaca agtcatgttt attgatatgc tgtttcctta 2787361 cgagctttac gatgtcattc gcgaaaaata cgtccgcaag tctgctttac cgaaggaaga 2787421 attagaatca gcttttgaat atgaacgcat taaagcaaac gcattgcggc agcttattta 2787481 agaccatcat ttcccccgca tatcgggggt ttgatattta taagataaag ggtaattaaa 2787541 tacatgcgga ggttgcaaat atgaaaaaga ttgtcggcgc tttagccgtt tttgtgatta 2787601 catatgcgct gttttcagcc gcaggctacc tgtttcctgt ggaccaagaa tggtacaatt 2787661 cattgaaaaa accggactgg acgccaagcg gaactgcgat cggcatcatt tgggccatcc 2787721 tgtttgccct gatctccctt tcagcagcca ttgtatatgc tgcgttttca tttaaaggtg 2787781 cgaaaagctt ttggtttaca cttttgataa attacgtgct caatcaagcc ttcagctatt 2787841 tccagtttac gcaaaaaaat ctgctggctg catcgcttga ctgcctgctt gtcgccatca 2787901 cagcaatcgt attactgatc attgccaaaa aatacagcag agccgcaagc tatcttcttt 2787961 tgccttattt tttatggagt gcatttgcga cgttcttatc ctttacaatc aattcaatga 2788021 atctgtgaac aaaaaaagcc gcttatacag cggctttttc acatcatcgg cttgatgccc 2788081 caaatgtcct tcgcatattc ccggatcgtg cggtcgctgg agaaatatcc agaatgagca 2788141 atgtttacaa tcgaatgctc agaccatttc cttcgctctc gataatcagc ttgaattcgc 2788201 tcctgtgcat ctgcatatga gctgaaatcc ttcagcacaa aatactcatc attatgcgga 2788261 agcagcgagt caaagatcga ttcaaattca tctgcctctc cttcaaaaaa accattgatc 2788321 aactgatccg ctacctgcct gattctcctg tcatgctgat aatattccct cgacctatag 2788381 ccgccgtttt cctgatacga tagaacctca tccgccttta agccgaacgt gtaaatacag 2788441 tcagggccca cccgctcaag gatctcgata tttgcgccgt catgcgtgcc gatcgtcaaa 2788501 gccccgttca tcataaactt catattccct gtaccagacg cttccttgct tgcggttgaa 2788561 atttgctcac ttacgtctga tgccggaaaa attcgctcag ccatagaaac tctataattt 2788621 tctaaaaaaa caactttgat cagctgtttg accgccggat cataattgac tttttctgcg 2788681 acagaatgga tcagcttaat gattttcttg gcataataat agcttggtga agcctttgcc 2788741 ccgaaaataa aggtttgcgg gtagattgaa aaccccgaat cctccttgag gcggttatac 2788801 aaatacataa tgtgaagaac attcagcagc tgccgtttat atgcatgaag ccgtttcacc 2788861 tgtacgtcga atatgctctc agggttcaca accaccccgg ccgtgcaaaa aatcaaatcg 2788921 gcaagctctt gttttttctt gcttttgttg ttttgaaact gttcaataaa tgcaggatca 2788981 gtggcgtacg gttctaaacg gatcagtgat tccggctgct tgacccattc atcgccgatc 2789041 gcctctgtaa tgatggcaga caagcctgga ttcgctttta acagccagcg cctgtgggca 2789101 attccattcg tcttattgtt aaaacgattc ggaaacagca agtgaaagtc gcgcatctcc 2789161 ctttccttta atatatcgga atgtattttt gcaacgccat ttacactgta gctgcctact 2789221 atggccagat gagccatttt gacaacacca tgcgctgtaa tcgccatgtt ctctatcctt 2789281 ttccagtctc caggatactt ttcccaaact gcacggcaaa acctctcatt gatctcttca 2789341 ataatcatgt acattcgcgg gagcagcggc ttaaacaaat gaatcggcca tttctcgagc 2789401 gcttctgaca atgttgtatg atttgtataa gaaatcgtat gtacagtgat atgccaagct 2789461 tcttcccagc tcatgttctc ttcatcgagc aaaatccgca ttagctcagg caccgcaagc 2789521 gcagggtgag tgtcattaat atgaatgctc acttttttat gcaggccgga taaagattta 2789581 tgtgttttac ggtaattgtt cacaatgctt tttaagcttg cgcatactaa aaaatactgc 2789641 tgcttcagcc gtaaaatttt cccctcatca tgggtgtcat cgggatataa gaattcagaa 2789701 accgcttctg tttctcgctt ataagacaaa atattaccgc cgtgataatg ggcatagggc 2789761 tcggcgttcc aaagccttaa cgtgttgaca gtgcccgttt catagccgat gatcgggata 2789821 tcataaggaa cagcggtaac aattgtcgct tgttcatggc gaaaatgcag gcgcccgctt 2789881 ttttctgtca tatggacttc gccccaaaac ggcacgtcca ctgcttgatc cgcattcctt 2789941 acttcccata cgttcccgtt tttcagccat tgctcaggca gctccacctg atgtccgtct 2790001 acaatttttt gctcaaacaa accatgctta taacgtatgc ccatgccgtg cccaggcagg 2790061 ttcaacgaag caagcgaatc taaaaagcaa gcggccaagc gcccaagtcc gccattgccg 2790121 agacctgcat cgttctctat ctgaaggatc tcctctaaat tgatgccgat ttcctttaaa 2790181 ccagcttcta caacatcacg aacaccaaga ttcattaagt tttgctcaag gagctgaccg 2790241 agcagaaatt cgattgataa ataatatgtc tgcttcccgg aatttgatct gcttttttca 2790301 ttcgtttcga tccaatcagc gctgatatac tctctgacca tattgcccaa cgttttatat 2790361 tgatccagct tggcagaatc tttaaagctt tttccgcacg tcatttccag acgctttaaa 2790421 aataagtctg caaagcgttc tttactcgag aacatcccgt ccactccttg tcacctgctc 2790481 gaaaatacgc tgatactctt tagccgactt cccccagctg taatctgcat tcatagcggt 2790541 cttcacgatg ctcttccata catcctgttg gcaataaaac gacagcgccc tttctatcgt 2790601 aaatttcaga tcatgcgcat taaaggcgga aaacgtaaag ccattgcccg ttccctcttc 2790661 ctcctgatag gcacggacag tgtcgtaaag accgcccgtt tccctgacaa tcggaatggc 2790721 gccatattga agagcaatga gctgccccaa accgcacggc tcaaatttcg acggcatcaa 2790781 aaacatatca gagcccgcat aaatttgatg ggctagcggc tcatcaaacc cgatataagc 2790841 ccggcacttc tcatgaaaag caaattctgc ataccggaaa taatcttcaa attcacgttc 2790901 tcctgtgcct agcacaacca gctgtatgtc ttgctcctca agaagttcgt gcataattct 2790961 gcggacaaga tcaagcccct tttgtttagt gagccttgtc accatactga tcagcggaat 2791021 atcgtttttc tctggaagcc ccatccgctg ctgaagcttc gttttgtttt ccagcttgca 2791081 tgcaagatcc cctgaatcgt attgcgcctc tatataaggg tcgcttttcg gctgatagaa 2791141 cgtatcatca atgccattta atatgccggt tacatcatct tccctatatt gcaaaacctg 2791201 ttccaactgc tcaccataat acggcgtcat gatttcattt ctgtaagtgg ggctcacagt 2791261 tgtcacatga tcagccgcaa tgatgcccgc tttcataaaa ttaacaaatc cgttgcattc 2791321 taacctttca taatgaaaat gatccatctc aagacccagc aagtcatgtg tgacatcagg 2791381 agggaatatg ccttgaaact gcaggttgtg gatcgtgagc acgcttttca tccgttcata 2791441 aaaaggatgt tttctgtact cctctttcag caaataattg accatcgctg tatgccaatc 2791501 gtgagtatga acaatatcgg cttgaacatt cacaactttg gcagcctcca gcacagctct 2791561 tgaaaaaaag gcaaaccgct caccgtcatc ataatgcccg tacaacgaat ccctgttgaa 2791621 atagtactca ttgtcgatga agtaataatt cacatcattc tctgccatat gttcaattcc 2791681 gcaatattgc tgccgccagc cgacagctac ggtacactca gcctgttttt tcatacgctt 2791741 tttccacggt tcaggtattt ggctgtactt cggcagcatc acagctacct cattgcctaa 2791801 tcgcgcaagc gcctttggca gagcacctgc tacatcggca agacctcctg atttcacaaa 2791861 tggggtgcat tctgacacag caaataatat cttcaagaat tcatcagctc tccttgcacc 2791921 aaaccttttc ttaatacaag cggctgctca gctgttcctg cagcttccgt cgccttgccg 2791981 attttaacat ccttatccga aatgacctgc tcaagaagac aatcctctcc aatctgcgtt 2792041 ttttgcataa taatgcagtt tttcagcttc gtaccctttc cgacatggac cgccctgaac 2792101 aaaatgcagt tttcaacctc tccttcaagc acacagccgt ttgccaccaa agaatttttg 2792161 acagtgctgt gctttccgta tttcgtaggc ggctcatcct tcacttttgt atagatcggc 2792221 tgctgcggca aaaacacctg ctgccaaaaa cgaggctgaa tgagctccat actgtgggta 2792281 taatattttt ccaccgaatc aatgacagcg gcataacctg aatattcata agggcaaatg 2792341 gtcagggcgg aagattcctt ttcaacagcc tcctgaatgg ttttatagcc tttttcgcta 2792401 tgtccgtaga tcagatcctt taaaagcgtt gttgacatga tatagatttg cagcgactgg 2792461 ccgtcctgaa atacctcggt gacgtcgcag ccaacctcct gatggcgttt cagcacatat 2792521 tgaaattgaa tgttgcatac ggtatggctg ttggagatta cagcatattg ctgagtgctt 2792581 ctgtggaagt aatctagatg gtccgaaaac tggcgaaagg aaccgaattc atcgtattcg 2792641 tgatgaagat ggggagacgg gaaaaaaaag aggccgtcct ttttccggtg caaatcccat 2792701 tccttacccg ccccaaggtg atccatgagc gaacggtaac gatacttcgg aaaaattgca 2792761 acactcctaa tatccgcatt caccatgttg gaaagcataa aatcaatcag tcggtacctg 2792821 ccggcaaaag ggatcgcccc gagcgaccgc tgtgctgtta aatcctgaag agaatgctta 2792881 tatgtggttt catctataac acctaacatt tgattattga acactgactc tgccccctct 2792941 tcagtaatta aatcaattct ttttctacaa attcctctga aacgagcagc acctcttcaa 2793001 tgtctttttc ggagcgaatc actgcgccat ccggcagcac catcccatta ggaacgatgg 2793061 cattttcaat gactacatgc tccccaatcg tcacatccgg cattatgacg gatgatgtaa 2793121 cagtcgtatg cttaccaaca gtcacacctt gaaaaagaac ggagtgagac acatttccat 2793181 atacaacaca accttcgttc acaagcgaat cttgaacctg cgcatcagat gaaataaatt 2793241 gcggaggctg atttggattg acggagtaaa ttttccattt gcgttcaaac agcttcagct 2793301 ccgagtcctc ttttaacaaa tccatattgg cttcccacaa gctctgcacc gttccgacat 2793361 ccttccaata tcccttgaac ggataagcag aaagcttctt tttctcttcc aaaagcagtg 2793421 gaataatgtc tttgccgaag tcgtggctag aataagggtt ttgatcgtcc atctcaagat 2793481 actgtttcaa aagcggccaa ttgaatatat aaattcccat tgaggcaaga ttgctcttag 2793541 ggaatttggg cttttcatca aaatgtgtga tcgtcccatc tggattggcc ttcatgatgc 2793601 cgaaccggct tgcttcctcc cagcccactt cgatgacaga gatggtcaca tctgctttct 2793661 tttcaatgtg ataatcaagc attttgccgt agtccatttt gtatatgtga tctcctgata 2793721 aaatcagtac atactcagga tcatactgat tcaaataatt gagattttca taaatggagc 2793781 ttgccgtccc tttataccat ttgacttctg atgactcggc ataagggggt aaaaccgtca 2793841 cgccgccatt atatctatcc aggtcccatg cactgccgat cccaatatag gaattcagct 2793901 cgagcggctg atattgcgtt aaaatcccga ctgtgtctat gcctgaatta gaacagttgc 2793961 ttagggtaaa atcaataatc ctgtattttc ccccgaaaga tacagccggt ttggccatat 2794021 tttttgttaa tccgctgaga cggctgccct tcccgccggc aaggagcatg gctacacatt 2794081 gttttttcat ctttttatct ctcctctttt tttaaccgcc cgtaaaatcg agatgccgta 2794141 aggggggatg gtcatcgtga tataacacgg tttatgatga agtgctccct ttttagccga 2794201 taacggcttt ttgttgattt gccctgagcc tccatatgtt tcactgtcac tgttaagcac 2794261 ttcaatgtat tgagtaaaaa aaggaactcc aacatcatat tgatgataga ccacgggtgt 2794321 aaaattacaa atgatgacaa gcgcctcacc gtgcttttgg ccataacgaa taaaagaaaa 2794381 gattgattgt tcgtcattat ggacatcaat ccattcaaac gattgtgcac gatggtcatg 2794441 ctcataaagg attttgcttt tttggtaaaa gcggagaaga tcttgcgtaa aaacgctggc 2794501 tttctgatgc atggggaagg agtccaaaaa ccaatcaagc tgttctgtat ctttccattc 2794561 atcaaattga gcaaactctg atcccataaa gatcaatttc tttccgggat gcactgtcat 2794621 atagcccagc aaaagccgat actgggcaaa tttctgccag tagtcgccag gcattttatt 2794681 gagaagtgat ttttttccgt atacgacttc atcatgagaa aacggcaata caaaatgttc 2794741 actaaacgca tatagtaatg aaaaagagat aagctgatga caatgccgcc tttcttcggg 2794801 cggcgtctcc atgtatttca gtacgtcatt catccatccc atattccatt tataatgaaa 2794861 accaagcccc ccttcctcaa cggcacctgt cacttgaggc cattctgtag aatcttctgc 2794921 aatcatcatc acatggggat atgcctctct catggtttga ttgagttttt ttaaaaaatc 2794981 aacagcatat ggattcgtgt ggcgttcatc ctgatttggc caatacaaga tattagccac 2795041 tgcatcaacc ctaaatccat ctatatgata gaattccgcc cagtacaacg cattcgaaat 2795101 taaaaaacta tgaacttccg gtttccccag gtcaaagttt gccgtgcccc ataaccagtt 2795161 ctcccgatca cgttcttctt tgtattcata aagcggttct ccatcaaaca tataaaggcc 2795221 atgtgcatct ttacaaaaat gtccggggac ccaatccaaa atgactccga tattttgttg 2795281 atgacattca tccacaaact tcatcagatc atgcggcggg ccaaacctgc ttgtcgggct 2795341 gtaatacccc gttccttggt acccccatga acgatcatat ggatgctcat acacgggaag 2795401 cagttcaata tgggtaaacc catgcttctt gatataaggg ataagcgtct gacttaattc 2795461 tttataggaa taatgcctgc catcagaatg cttcttccaa gacccaagat gcagttcata 2795521 aatgaaaaca ggtttttcat acagcgtctt agccttctgt ttcttttgcc atttttgatc 2795581 ttgccagctg tatccttcca aatcgtaagt aagtgacgct gtgtttggtc tgacttctga 2795641 ataaatagcg tatggatctg ccttcagcct gatctcaccg ttattcgtca caatttcgta 2795701 tttatatcgt tccttttctc ctatacctgg aataaataac gtccaaatgc cattatcatt 2795761 cactctgtgc atcacatgct cttctccaga ccagctgtta aaatctccag ccactcgtac 2795821 ttccgacgca tgaggcgccc acacacagaa ttcatatccg cttttgccat tcagctcgcg 2795881 gtaatgcgag ccaaacagct gatagctttt aaacagactg ccttcgtgaa aaagataaac 2795941 atcatgtgct gtcgggctgg cagcggccat gtaatcatcc tttctgacat catagttttc 2796001 atttatagta tttattcgaa gaaataaaaa aaagcccttt cctgaaagcg cttatactta 2796061 tagacaatta acttcatttt ctgaagaaaa acgaaatata tggagatttt tgtagtctgt 2796121 ttttaaaata aagaacaaaa tctaagacat atcatgattt ataaaaacaa aaaaaccttg 2796181 caggatatgc aaggcttctg gatgacccgt acgggattcg aacccgtgtt accgccgtga 2796241 aagggcggtg tcttaaccgc ttgaccaacg ggccgataat tatgatatct gtaatcatat 2796301 ggcggagaag gagggatttg aaccctcgcg ccgcttacac gacctacacc cttagcaggg 2796361 gcgcctcttc agccacttga gtacttctcc atttggctcc acaggcagga ttcgaacctg 2796421 cgaccgatcg gttaacagcc gatagctcta ccactgagct actgtggaac aaaagtcatg 2796481 gtgggcctga atggactcga accatcgacc tcacgcttat caggcgtgcg ctctaaccag 2796541 ctgagctaca ggcccatgac gatatagaaa tggagcgggt gatgggaatc gaacccacga 2796601 catcagcttg gaaggctgag gttttaccac taaactacac ccgcaatttt tatttggggc 2796661 gattgatggg aatcgaaccc acgaatgcca gagccacaat ctggtgcgtt aaccacttcg 2796721 ccacaaccgc caaagcatat tgataaatgg tggctcggga cggaatcgaa ccgccgacac 2796781 acggattttc agtccgttgc tctaccaact gagctaccga gcctaagtat ttaaatggcg 2796841 gtccggacgg gactcgaacc cgcgacctcc tgcgtgacag gcaggcattc taaccaactg 2796901 aactaccgga ccattttaaa atttggttgc gggggcagga tttgaacctg cgaccttcgg 2796961 gttatgagcc cgacgagcta ccgaactgct ccaccccgcg atgattagga atatgtatgg 2797021 cggaggaaga gggattcgaa cccccgcggg ctttgacacc cctgtcggtt ttcaagaccg 2797081 atcccttcag ccagacttgg gtattcctcc gtatagtggt ggaccttgta ggactcgaac 2797141 ctacgaccgg acggttatga gccgtctgct ctaaccaact gagctaaagg tccattggta 2797201 gcggcggagg ggatcgaacc cccgacctca cgggtatgaa ccgtacgctc tagccagctg 2797261 agctacaccg ccaaatattt ttgaaatcaa gtggagccta gcgggatcga accgctgacc 2797321 tcctgcgtgc aaagcaggcg ctctcccagc tgagctaagg ccccaagaat ggtcgggaag 2797381 acaggattcg aacctgcgac cccatggtcc caaaccatgt gctctaccaa gctgagctac 2797441 ttcccgattt catatagatc atggcgcgcc cgagaggagt cgaaccccta accttttgat 2797501 ccgtagtcaa acgctctatc caattgagct acgggcgcaa aacttaatgc cgagggccgg 2797561 acttgaaccg gcacggtagt cacctaccgc aggattttaa gtcctgtgtg tctgccaatt 2797621 ccaccacccc ggcgtggatg gtatagttgg agcggaagac gggattcgaa cccgcgaccc 2797681 ccaccttggc aaggtggtgt tctaccactg aactacttcc gcagaaatgg tgcggatgaa 2797741 gggacttgaa cccccacgtc tgtaaagaca ctagagcctg attctagcgc gtctgccaat 2797801 tccgccacat ccgcaacatg taaatggtga gccatgaagg actcgaacct tcgaccctct 2797861 gattaaaagt cagatgctct accaactgag ctaatggctc ttcttacaat agacttgaat 2797921 attatatcat ataaaagtgg tgccggcaag aggacttgaa cccccaacct actgattaca 2797981 agtcagttgc tctaccaatt gagctacacc ggcatatatg taaaaccgat atgtataatg 2798041 aaaaatggtg gaggatgacg ggctcgaacc gccgaccctc tgcttgtaag gcagatgctc 2798101 tcccagctga gctaatcctc catacttgca ctaacgtgca attgcttggc ggcgtcctac 2798161 tctcacaggg ggaaaccccc gactaccatc ggcgctgaag agcttaactt ccgtgttcgg 2798221 tatgggaacg ggtgtgacct cttcgctatc gccaccaaac aaattgagag tgttctctca 2798281 aaactagata acaggtgtga catcattcaa aaatatggtt aagtcctcga tcgattagta 2798341 tctgtcagct ccatgtgttg ccacacttcc acctcagacc tatcaacctg atcatctttc 2798401 agggatctta cttccttgcg gaatgggaaa tctcatcttg aggggggctt catgcttaga 2798461 tgctttcagc acttatcccg tccgcacata gctacccagc gatgcccttg gcagaacaac 2798521 tggtacacca gcggtgcgtc catcccggtc ctctcgtact aaggacagct cctctcaaat 2798581 ttcctgcgcc cgcgacggat agggaccgaa ctgtctcacg acgttctgaa cccagctcgc 2798641 gtaccgcttt aatgggcgaa cagcccaacc cttgggaccg actacagccc caggatgcga 2798701 tgagccgaca tcgaggtgcc aaacctcccc gtcgatgtgg actcttgggg gagataagcc 2798761 tgttatcccc ggggtagctt ttatccgttg agcgatggcc cttccatgcg gaaccaccgg 2798821 atcactaagc ccgactttcg tccctgctcg acttgtaggt ctcgcagtca agctcccttg 2798881 tgcctttaca ctctgcgaat gatttccaac cattctgagg gaacctttgg gcgcctccgt 2798941 taccttttag gaggcgaccg ccccagtcaa actgcccacc tgacactgtc tccccgcccg 2799001 ataagggcgg cgggttagaa ggtcaataca gccagggtag tatcccaccg atgcctccac 2799061 cgaagctggc gctccggttt ccaaggctcc tacctatcct gtacaagctg taccaacatt 2799121 caatatcagg ctgcagtaaa gctccacggg gtctttccgt cctgtcgcgg gtaacctgca 2799181 tcttcacagg tactataatt tcaccgagtc tctcgttgag acagtgccca gatcgttgcg 2799241 cctttcgtgc gggtcggaac ttacccgaca aggaatttcg ctaccttagg accgttatag 2799301 ttacggccgc cgtttactgg ggcttcaatt cgcaccttcg cttacgctaa gcgctcctct 2799361 taaccttcca gcaccgggca ggcgtcagcc cctatacttc gccttacggc ttcgcagaga 2799421 cctgtgtttt tgctaaacag tcgcctgggc ctattcactg cggctctctc gggcttgcac 2799481 cctaacagag caccccttct cccgaagtta cggggtcatt ttgccgagtt ccttaacgag 2799541 agttctctcg atcaccttag gattctctcc tcgcctacct gtgtcggttt gcggtacggg 2799601 cacctctcac ctcgctagag gcttttcttg gcagtgtgga atcaggaact tcgctactat 2799661 atttcgctcg ccatcacagc tcagccttat gggaaacgga tttgcctatt tcccagccta 2799721 actgcttgga cgcggatatc caataccgcg cttaccctat cctcctgcgt ccccccattg 2799781 ctcaaatggt gaggaggtgg tacaggaata tcaacctgtt gtccatcgcc tacgcctttc 2799841 ggcctcggct taggtcccga ctaaccctga gcggacgagc cttcctcagg aaaccttagg 2799901 cattcggtgg aggggattct cacccctctt tcgctactca taccggcatt ctcacttcta 2799961 agcgctccac cagtccttcc ggtctggctt cacagccctt agaacgctct cctaccactg 2800021 ttcgaagaac agtccgcagc ttcggtgata cgtttagccc cggtacattt tcggcgcaga 2800081 gtcactcgac cagtgagcta ttacgcactc tttaaatggt ggctgcttct aagccaacat 2800141 cctggttgtc taagcaactc cacatccttt tccacttaac gtatactttg ggaccttagc 2800201 tggcggtctg ggctgtttcc ctttcgacta cggatcttat cactcgcagt ctgactccca 2800261 aggataagtc attggcattc ggagtttgac tgaattcggt aacccggtag gggcccctag 2800321 tccaatcagt gctctacctc caagactctt accttgaggc tagccctaaa gctatttcgg 2800381 agagaaccag ctatctccag gttcgattgg catttcaccc ctacccacac ctcatccccg 2800441 cacttttcaa cgtgcgtggg ttcgggcctc cattcagtgt tacctgaact tcaccctgga 2800501 catgggtaga tcacctggtt tcgggtctac gaccacgtac tcatgcgccc tattcagact 2800561 cgctttcgct gcggctccgc atcttctgct taaccttgca cgggatcgta actcgccggt 2800621 tcattctaca aaaggcacgc catcacccgt taacgggctc tgactacttg taggcacacg 2800681 gtttcaggat ctctttcact ccccttccgg ggtgcttttc acctttccct cacggtactg 2800741 gttcactatc ggtcactagg gagtatttag ccttgggaga tggtcctccc ggattccgac 2800801 ggaatttcac gtgttccgcc gtactcagga tccactcagg agagaacgaa gttttgacta 2800861 cagggctgtt acctcctatg gcgggccttt ccagacctct tcatctacct cgttcttttg 2800921 taactccgta cagagtgtcc tacaacccca agaggcaagc ctcttggttt gggctgatcc 2800981 cgtttcgctc gccgctactc agggaatcgc atttgctttc tcttcctccg ggtacttaga 2801041 tgtttcagtt ccccgggtct gccttctcat atcctatgaa ttcagatatg gataccactc 2801101 cattacgagt ggtgggtttc cccattcgga aatctccgga tcaaagcttg cttacagctc 2801161 cccgaagcat atcggtgttc gtcccgtcct tcatcggctc ctagtgccaa ggcatccacc 2801221 gtgcgccctt tctaacttaa ccgttaaaaa gaatcactat gtgatatctt gtgttactaa 2801281 ttgaatgtga tgtctactgt tatctagttt tcaaagaaca cgtttcgaag gaatgatcct 2801341 tcaaaactaa acaagacagg gaacgttctg tttataagac cttgggtctt atattccgta 2801401 taatatcctt agaaaggagg tgatccagcc gcaccttccg atacggctac cttgttacga 2801461 cttcacccca atcatctgtc ccaccttcgg cggctggctc ctaaaaggtt acctcaccga 2801521 cttcgggtgt tacaaactct cgtggtgtga cgggcggtgt gtacaaggcc cgggaacgta 2801581 ttcaccgcgg catgctgatc cgcgattact agcgattcca gcttcacgca gtcgagttgc 2801641 agactgcgat ccgaactgag aacagatttg tgggattggc ttaacctcgc ggtttcgctg 2801701 ccctttgttc tgtccattgt agcacgtgtg tagcccaggt cataaggggc atgatgattt 2801761 gacgtcatcc ccaccttcct ccggtttgtc accggcagtc accttagagt gcccaactga 2801821 atgctggcaa ctaagatcaa gggttgcgct cgttgcggga cttaacccaa catctcacga 2801881 cacgagctga cgacaaccat gcaccacctg tcactctgcc cccgaagggg acgtcctatc 2801941 tctaggattg tcagaggatg tcaagacctg gtaaggttct tcgcgttgct tcgaattaaa 2802001 ccacatgctc caccgcttgt gcgggccccc gtcaattcct ttgagtttca gtcttgcgac 2802061 cgtactcccc aggcggagtg cttaatgcgt tagctgcagc actaaggggc ggaaaccccc 2802121 taacacttag cactcatcgt ttacggcgtg gactaccagg gtatctaatc ctgttcgctc 2802181 cccacgcttt cgctcctcag cgtcagttac agaccagaga gtcgccttcg ccactggtgt 2802241 tcctccacat ctctacgcat ttcaccgcta cacgtggaat tccactctcc tcttctgcac 2802301 tcaagttccc cagtttccaa tgaccctccc cggttgagcc gggggctttc acatcagact 2802361 taagaaaccg cctgcgagcc ctttacgccc aataattccg gaaaacgctt gccacctacg 2802421 tattaccgcg gctgctggca cgtagttagc cgtggctttc tggttaggta ccgtcaaggt 2802481 accgccctgt tcgaacggta cttgttcttc cctaacaaca gagctttacg atccgaaaac 2802541 cttcatcact cacgcggcgt tgctccgtca gactttcgtc cattgcggaa gattccctac 2802601 tgctgcctcc cgtaggagtc tgggccgtgt ctcagtccca gtgtggccga tcaccctctc 2802661 aggtcggcta cgcatcgttg ccttggtgag ccgttacctc accaactagc taatgcgccg 2802721 cgggtccatc tgtaagtggt agccgaagcc accttttatg tttgaaccat gcggttcaaa 2802781 caaccatccg gtattagccc cggtttcccg gagttatccc agtcttacag gcaggttacc 2802841 cacgtgttac tcacccgtcc gccgctaaca tcagggagca agctcccacc tgtccgctcg 2802901 acttgcatgt attaggcacg ccgccagcgt tcgtcctgag ccaggatcaa actctccgat 2802961 aaatggatca caggttaagt tcaccgcatc ctgcggcgac acctgtgtga cctgcgtcgt 2803021 gcaggcccta gtttgactga ctacgcacat cgcagtgcga tttttaaaaa ctgaattaac 2803081 aggtacgttt tgtcttgttt agttttcaaa gatcatttcg ttacttctca atgaagcagc 2803141 tttactaata taacattcag cttctttttt gtcaacaact tttttcaagt tgttttgaag 2803201 catctagttt gtgtccgctg tgcatcagcg acgtttaata atataacacc tgtatttatt 2803261 tattgcaata gttttttaaa aaaaatctat aaaacaaata aactataatc ctcgccatga 2803321 tttctaaagc gtgtgtatca tataagtttc ttaaaagaac atatacatca gtcatgtgat 2803381 cttgttgttt ttttcgtttt cttgtatagt agaaacgaac taaatactga tgaccacaag 2803441 gggagcatta aagctgagag tgagcggttt cgttctgacc ctttgaacct gttagttaac 2803501 gctggcgtag ggatgtggca aagtcaaatg aattgcagat cgtaaagcag tgcgtggaac 2803561 ttttctcatc cttccgcgtg ctgctttttt gttgtccttt tggttgtctg tcaatggaag 2803621 gagatagata tgaatcaatc taagcaactg gttcgcctta ttgaaattgc cattatgaca 2803681 gcggcagccg ttattttaga cattgtctca ggaatgtttc ttagcatgcc tcaaggaggc 2803741 tcggtctcca tcatgatgat tccgatcttt ttaatttcgt ttcgctgggg tgtcaaagca 2803801 ggtcttacta caggtttgtt gacaggtcta gtacaaatag caatcggaaa cttgtttgct 2803861 caacatcctg tacagctatt gttagattac attgtcgctt tcgcagcaat cggcataagc 2803921 ggctgtttcg cttcttctgt ccgtaaagcc gctgtatcaa aaacaaaagg gaaattgatt 2803981 gtttcagtgg tcagcgcagt ttttatcggc agtttgctgc gctatgccgc gcatgtcatt 2804041 tcaggagctg tgtttttcgg cagctttgct ccaaaaggaa caccggtatg gatttattct 2804101 ttaacttata atgcgactta catggttcct tcattcatta tttgtgcaat tgtcctatgt 2804161 ttattattta tgacagcacc ccgtctgctt aaaagtgaca aagcgtaaaa gtaacaatcc 2804221 cccagcgaat tccgctgggg gatttttcgt tatctgttaa gaagtgtttt taaagctgaa 2804281 agatccggcc agccaagacc tacttctttc agccttactc cggcaatttc aaagttgtcc 2804341 tccgctactc tttcaggtga ataggcctga taaaatataa tcgagggatt ctgctcaata 2804401 acccaaacaa acatacttga aaaaccatgt tgaagcaaaa actccgctcc ttttgctaag 2804461 agcgccctgc ctgcaccttg ccgctggcgc tcttccagaa gataaatagc gtataactcg 2804521 ccgtcatagc cttcttgttc agagcgaata ggtccaaatg aagcaaagcc gaatactgaa 2804581 cccttttcgt cctgagcaac aaatactccc tttaacgagc gacttttcca tttgtcttca 2804641 aattccttat agttcaggct gtttaaataa tcaatcggga taatttcgtg gtatgttgtc 2804701 ctccagctgt ctacatgcac ttttgcaatg tcctttatat cctctaactt cgcttcacgt 2804761 acagttacca tacggttctg ccctttcctt actctgattt ttggatcgtt ttggcttctt 2804821 tgatttcatt tgttaattca ttaatgcttt gttttacgtt tccttttcct gaaaagttct 2804881 caagcatttc ttttacatca attcctgagg atgcttttaa actttcttgc agacttgaca 2804941 ttaagttcgt cgcatagctg gttactttgt ttgctccgct tgattcaccg cttcctcctg 2805001 tatcgacaac ggtgatttta tcaatatttg aaagaggtgc cgctgcttgt ttcgcgtatt 2805061 ccggaagcat tttgacaatc atatcgaaaa tcgccgcctg cccgtactgt tcaaaggcgg 2805121 ccgcaatttt ctcttttgct tccgcttctg caagaccttt caggcggata acctctgctt 2805181 ctgtctctcc tttcgctttt tccgcttctg cttttgctag cccgtcaatt cttacttttt 2805241 ccgcctcagc ctttgccatt gcttcaatac tgtacttctt ggcatcggct tccgcgagct 2805301 gtttggcttt ctcagctgct gcggactgct caacagaata acggtctgca tcggcttttt 2805361 tctttacctc tgagtcgtat tgacgttcac ggcgaagaat ttctttttct tctagttcta 2805421 tttgtttttg gcgttcgata attttaacct gcatttcctg ctctgtgact tgctggcgcg 2805481 ctcgggcagt ctctaaatca tatgcttggt cggcattcgc ttttgccgta tcttgttctc 2805541 tgcggaattc agccattttg agctgattga ttttttcagc ttcagcgatt tccgtcgccc 2805601 gttcaagttc tgattttttt gcgtctttat cggcttctgc ccgcttaatt cgggtttctt 2805661 tatcagcctc tgctgttgcg atatcagcat cgcgttttac ttgggcaatt ctcggtttcc 2805721 ctaatgattc aagataaccg tttttatcac gaacatcttt aatggtaaac gagacgatta 2805781 caagtcccat tttcgcgaga tcctgtgaag cgacacgctg cacctcttga gagaattttt 2805841 ctctgttttt atagatttct tctactgtca ttgagccgag aatggaacga aggtggcctt 2805901 ctaaaacctc ccgcgcttcc tgctcacggt cgtcttttga tttccctaaa aattgttcgg 2805961 ccgctgtagc gatttctcct atagaaccgc cgattttaat aatcgcagtt ccatcggcca 2806021 ttactggcac tccttgttct gtatagactt caggtgtcga aacatcgagt ttgcttgata 2806081 ataggcttag cggctctgcc tgctggaaga cgggaaggac aaaggttcct ccgccgcgga 2806141 cgattttaat acggttgccg ccttcatcga catgaacatt tttattaccc agatagctcc 2806201 ctgttacaat taacgcttca tcaggccctg ctgtacgata cttcgtaata aacacagcta 2806261 ttagtgcaat taataaaaag aatacaactc cgatgatcat tataatcggc attgtcatat 2806321 caaattcctc cttttatgtt aaatgggttc atgcggagta accgaaagaa ctccgttgtt 2806381 aatatctacg actaacaccg ttgtcccgta actgatctgc tgattatcaa aactgaccgc 2806441 tgactttgaa atggtcccgc ctatcccttc tatgaccact tcaccaaacc cgtcaaccgg 2806501 cacagctgta atcactttac cgagtcttcc tctgagatca tcttctctat atgccaatga 2806561 ttcttctgca gatgataatg gcaccagtac aaagatgtga agcaatacca ccagcatgat 2806621 cgaaaggatg caagataaaa gcgcaatcag caagcttgac agaggcaata caagttcacc 2806681 tatatatccg cccgctgaaa aacatgtaaa aaatgagagc actaatgtcg gattaagaaa 2806741 cggaatgcct tctgacagcc ctgaaaatac atctccgaaa aacaggaata acagcgtaag 2806801 gctgcccgca ataataagcg tataaagata cattgtttgt ataggtactc caaataactc 2806861 caacttcctc atcctttctt catcaatgca ttgatgaacg gctgccgtta ccatttatac 2806921 gagacacctc gggaaaagtt tcaaaatttt aagacaaata acccatttga agtgctttat 2806981 aaatgataat tgcttatata tatggtaatg tcattttagg aggagatatg atgagtatct 2807041 ttaatgaagc cagattagaa acgtggaacg aattgaaagg actttctgac gaaaagctga 2807101 atcaaaagcc ttctgctgaa gaatggagca tacgggaagt tcttgaccat ttgaaaaaaa 2807161 tcgatatgac cgcacaaaaa atgttgaagg aacgtgtaaa ggacgctccg attaaagaaa 2807221 ttgaagaaaa accgcttgaa gtagcacagg acagaaataa taaacggaaa gccccgagtc 2807281 atcttgagcc tgcgcatgat tttatttcag gcagccaaat gaaacgtgag cttgatgtgg 2807341 taagagagca gctgactgct gcgattgcct ctctgaaaga agaagatttt gaaagagtgc 2807401 ttccgcatcc tgtgtttcaa gagctgactg tcagacagtg gatcgatttt atcggccatc 2807461 atgaaaaacg gcacctcagc caaatgaaag aaattaaaga aaagatagaa agggcctgat 2807521 ttaatcagac cctttctgct tttcgtttga cttttcgctg ataggaatga acttctattt 2807581 catcacctgt gtaaacagca ccaggtctct ccacaataca gacaatccct ctaatgccca 2807641 gtgcgtggcg gacgaaagcc gacgccagct tcggttggtc cggataataa gactgaatga 2807701 cttctcccgg ctggatacac ggatcatttt cgccctcaca cagcagagcc gctccgctcg 2807761 gaaaaataat ccggcttcct tcttttaatg aagtaagatc tggcataccg ctgactgcca 2807821 cattcgcccc gagccattcc ggcaaaattc tcggcactcc catttttaaa gcgatttcgt 2807881 tgcattcctc tattgaaaca attgaaattt gtctgcggtt gaaaatttca gtccctcttg 2807941 aaaacattgg ttctctggct cccgcttttt tggtcaggcc aaaatgcaag tcgccgggga 2808001 tgccgccata atcaaaatca agcttgtcca tttgctttgt tacgaagctt tttgtatctg 2808061 cgatatataa gccttccgct tttgcagtca tacgcttcca catcagctgg caccttcctt 2808121 cttatctaaa atttccacct atgcttcatt atcccaaaaa atcccgctct gtaaaggagc 2808181 gggattttga ttataccgtt ttaggcgtaa ggttaaagca gcgtttgtag atccagttgt 2808241 atgctttttc atttaaatct ctagggtttc cgaaggtttg cggatctttc attgcttctt 2808301 tagacaagcg ttcgatcata tcaggtgata ctccctgctc ttctaaagtc ggcacttcta 2808361 aatcttcgac cagatcatac atccaattga cagatgcttt cgcagcttct tctgttgtca 2808421 tcttgcttgt atcaataccg aacgctttcg caatacgcgc aaacttctca ggatagccct 2808481 tccagttgta ttccatgaca gggcccatca tcgccgctac acattggccg tgagcgactg 2808541 ggataatacc gccaagcgtt tggctcatcg catgagcagc gcccgctgat tcacttccgt 2808601 aagaaagacc ggcaagcatc gcagcctgcg ccattccgta ccttgcttcc agatcctctc 2808661 catcagcaaa tgccctcttg atgtaatgag cggcatactc aatcgccatt aaggcaaccg 2808721 catccgtgat tggctgtgca aatttcattg tatagcactc aatggcatgg gcgagcgcat 2808781 caattcccgt catagctgtt acatgcggag gcattgaaac atgaagctca ggatcaatga 2808841 ttgtcaagtg cgctgcaatc agcggaccgc ccgtgttgaa tttgaattct ctttcttcat 2808901 ctgtgataac cgcccattgg gttacttctg atccggttcc agctgtagtg ggaattgtcg 2808961 tcagcggagg aatgcggttt tccagcggtt ttttcccatc tgccgcttca taatcaagca 2809021 cgcttccttc gtgagtcgct tctactccga ttgcttttgc tgtatccatg gagcttccgc 2809081 ctccgactgc caccaaacca ttacagttct cttttttgta aagctcagat ccttcattca 2809141 ccagacggac aggcgggttt ggctcaactt tattaaagag taccacttca atgcctgctt 2809201 ctttaagtga ttcgattacg ggatcagcaa caccggcttt ataaatccca gggtctgtga 2809261 caaggagcgc ttttgaaacg cccagtgcag ctacttcctc acccgtatgc ttgatggctc 2809321 cgattccatg cttaatcaca gtcggaattt caaatgtgtg gaatttctgc atgctttcta 2809381 ccttcatatt taatgtcatc atcaatctcc ccctcttatg aattaaacca gttaaccgct 2809441 gccggttttg tattgcggta tacatgtttg acttctgtgt attcttcaag gcctattttt 2809501 ccaagctcgc gtccgaaccc ggattgctta tatccgcccc atggcgcttg tgcaaagtac 2809561 ggatgaaaat cgttgatcca aacggttccc attctcaagc gggctgctac ccgttcgcac 2809621 ttttcaatgt cttttgacca taccgctcca gccaagccat agatggtatc attcgcaagc 2809681 tcgattacct cttcttcaga gctgaaggtt tcgactgtca atacaggacc gaaaacctct 2809741 tcctgaacga ttctcatgtc agaattacag tttgagaaaa tagtaggttc atagaaaaag 2809801 ccgttttgaa gctcaggatc ttccgggcgt ttgcctcctg tctccagctt cgcgccttcc 2809861 tctattccga tctctacata tttttctacc tttgccctgt gctccgccga aataagcgga 2809921 ccgctttctg tctcagcatg aaaaccgttt ccgagtttta tgcgttttgc ccgtttgacc 2809981 agctccgcca aaaattgatc atgaatggca tcctcaacaa gcaagcggga acctgcagag 2810041 catacttggc cggcgtggaa aaatacagcg tttaaggcct gatcaaccgc aacttctaaa 2810101 tccgcgtcct tgaaaacaat atttgggttt ttcccgccaa gttcaagggc gatttttttg 2810161 acgtttccgc ttgccgcccg catgattttt ttgcctgttt caattccgcc cgtaaatgaa 2810221 atcaaatcga cgtctttgtt tacggcaagc tcgtcgccca ctgtggctcc cggtccaaga 2810281 acaagatttg cgacaccttt tggaacaccg gcttcttcca tcagcttaaa gactttgatt 2810341 gtcgtcagcg gcgtaatctc actcggcttc atgacgattg tgtttcctgc ggccagtgca 2810401 ggggcgattt tccagctcgc ttgaaggagc ggataattcc atggagtgat ctggccgcaa 2810461 accccgattg gctccctaat aattttgctt tctgaatcag gaatcggaga tgaaatgatc 2810521 tctccgccat ctttgtctgc caagccggcg taatattgaa aaacattggc gatatcgtcc 2810581 atatcggcct tgctttcttc gagtgttttt cctgtatcaa gagattcaag ctcagccagc 2810641 tcctcaagat cgcgtctgat taattccgca attttcagaa caatttttcc gcgttcaagc 2810701 ccggatagcg atgaccattc tcctttgtca aatgctctac gtgcggctgc gattgctttg 2810761 atggcgtcct ctcgccctcc ctcgcttaca gttgcaattt cttcttgatt aaatgggttg 2810821 ataatactgc ggatctgttc tttttcggca ctgatccatt ctccgtcaat gaataatgtt 2810881 tgactcatat aagcctcctt gacgtaaata aagtttgtta aataaaaatt taatgttttt 2810941 aacaacctta atctaacata tggtttttaa actgtcaaag tcccattttg atttttcttt 2811001 ttgacttttc ctcatgtttc gttaagataa agaacataaa gaaataactt aacgaattta 2811061 attttctaaa ggaaaagagg gtcagtatgg atgaaaatcc agaatttgca gctatagaac 2811121 aggctcggga tcttgttatt gactccattg ctgaaacgat ggatctttac ggaattaccc 2811181 gcagtgtcgg gattttatat gggacgatgt atatgaggga tgagatgacg cttgacgaaa 2811241 tgcgtgagga gttgcaaatg agcaaaccaa gcatgagcac tggcgtcaaa aagcttcaag 2811301 acttaaatgt agtgaaaaaa acatttcacc ggggcatccg caagcataca tttgtggctg 2811361 agaaggattt ctttaaattt ttcacaaatt tctttccacc taaatgggag cgggaggttc 2811421 aagtgaatgt aacagcgatc gaggaagctc aagctgattt acaaaaggtt ttatgcaagg 2811481 aagatctcga tgaggatatc aaaaatgaag cactgcagtt atatgatcag ctggaaagct 2811541 ctaaagctta ctatgactgg ctgaaacggc ttgctgaatc ggtgcagacc ggagaaattt 2811601 ttaaatttat accggtcgaa acaaagtaaa gcagaaaacg cctgggaaac taggcgtttt 2811661 tttgatgtaa ctactacaaa tttgaaaaat acgggaaaaa caccccattt acttccaaaa 2811721 tatttgatgg taattttatg taggtaaaat ttgtatttgg cctttcagag gaggtgaaaa 2811781 gcgggcaggc ctgtttaatt tatcattttt tagggggaat tttgttatga aacgcaaatt 2811841 attatcttct ttggcaatta gtgcattaag tctcgggtta ctcgtttctg cacctacagc 2811901 ttctttcgcg gctgaatcta catcaactaa agctcatact gaatccacta tgagaacaca 2811961 gtctacagct tcattgttcg caacaatcac tggcgccagc aaaacggaat ggtctttctc 2812021 agatatcgaa ttgacttacc gtccaaacac gcttctcagc cttggcgtta tggagtttac 2812081 attgccaagc ggatttactg caaacacgaa agacacattg aacggaaatg ccttgcgtac 2812141 aacacagatc ctcaataacg ggaaaacagt aagagttcct ttggcacttg atttgttagg 2812201 agctggcgaa ttcaaattaa aactgaataa caaaacactt cctgccgctg gtacatatac 2812261 tttccgtgcg gagaataaat cattaagcat cggaaataaa ttttacgcag aagccagcat 2812321 tgacgtggct aagcgcagca ctcctccgac tcagccttgc ggttgcaact aatgtaaaag 2812381 accggttaac gccggtcttt tttgcgtttt accctcccct ttttctctaa tccccgttat 2812441 cttttttctg gtttaaaatt taaattgaca aacactagaa acaggagtaa attcttgagt 2812501 gttcaatttc atacagtctc ttttaccgct taatcaaaca cgaacggggg aaccaacgat 2812561 tggctgtttt attaacagcc ttggggtgaa tcttactaag taagaggggg tactctgaat 2812621 ccctaatccg acagctaacc tcgtaggcgt atacagagag gaggtctatt atcggccatt 2812681 ctttgcaatg gtcttttttg tttcaaaaac gttaattcac taagggagat atgaacattg 2812741 ggaagaatta aaaataagca atttgccgtg atcgggctgg gccggtttgg cggcagcatt 2812801 tgtaaagaac ttcatagaat ggggcatgag gtccttgcgg ttgatatcaa cgaagaaaag 2812861 gtcaatgcat atgcttctta cgccactcat gcggtaattg ccaacgccac cgaagaaaac 2812921 gaattgcttt cattaggaat acgcaatttt gaatatgtga ttgttgccat cggagcaaat 2812981 attcaagcga gtacgctgac caccctatta ttaaaggagc ttgatattcc aaatatttgg 2813041 gtgaaggctc aaaactatta tcatcacaag gtgcttgaaa aaataggcgc tgaccgcatt 2813101 attcatcctg aaaaagatat gggggttaaa atcgcacaaa gcctttcaga cgaaaatgtt 2813161 ttgaattaca ttgatctatc tgatgaatac agtattgtcg agctgctggc tacgcgcaag 2813221 cttgattcaa aatcgattat tgacctgaat gtaagagcaa agtacggctg cacgatcctg 2813281 gccattaaac atcatggaga tatctgtctt tcccccgcgc ctgaagacat cattcgcgag 2813341 caagattgcc tggtgatcat gggccacaaa aaggatatta aacgttttga aaacgaaggg 2813401 atgtagacaa aggtgacact tcaaaaggat aaagtgatca aatgggttcg gtttacaccg 2813461 cctcaagtgc ttgccattgg ttttttcctt accattatca tcggggctgt cctattaatg 2813521 cttccgattt ccactacgaa gccattgtca tggatagatg ccctttttac tgcggcttcc 2813581 gctacaactg ttacagggct tgctgttgtc gataccggca ctcaatttac ggtattcggg 2813641 caaacagtaa ttatggggct gattcagatt ggcgggcttg gatttatgac atttgcggtc 2813701 ttgatcgtca tgatattagg aaaaaaaatc ggcttaaaag aacgaatgct cgtccaggaa 2813761 gccttaaacc agccgacaat cggcggtgtc attggccttg tcaaagtcct gtttctgttt 2813821 tcgatcagta ttgaattgat agcagcactc attttatcca tccggcttgt acctcaatac 2813881 ggctggtcat ccggcttgtt tgcaagtttg tttcacgcaa tatctgcttt taacaatgcc 2813941 gggttttcgt tgtggcctga taatttgatg agctacgttg gcgatcctac agtgaacctc 2814001 gtgattactt tcttatttat tacaggaggg atcggattta cggttctgtt tgatgtgatg 2814061 aaaaatcggc gttttaaaac tttttcttta catacaaagc tcatgcttac aggaacgctg 2814121 atgttgaatg cgatcgctat gcttacggtc tttattttag aatacagcaa ccccggcacg 2814181 ctcggccacc tgcatatagt ggataaactg tgggcctcct attttcaggc agtgacgccg 2814241 agaaccgcag ggttcaattc tctagatttt ggaagcatga gagaaggaac aattgtattt 2814301 actttattat tgatgtttat cggagcagga agcgcatcaa cggcgagcgg cattaagctg 2814361 actacgttca tcgtgatttt aacatctgtt attgcttact tgagaggtaa aaaagaaacg 2814421 gttattttcc gccgttccat caaatatccg attatcatta aagctttagc tgtgagcgtc 2814481 accagtttgt tcatcgtgtt tttagggatt ttcgccctga cgatcacaga acaagcgcca 2814541 tttcttcaaa ttgtgtttga aaccttttcc gcattcggaa ctgtcggcct tacgatgggg 2814601 cttactcctg aactgacaac agctggcaag tgtatcatca ttgtcatcat gtttatcgga 2814661 agaattggtc ctttaacgtt cgtgttttca ttcgcaaaaa cagagcaatc aaatatccgt 2814721 tatcctgatg gcgaagtgtt tacagggtga tatcaaaaaa atccggcgtg cagtcgccgg 2814781 attttttatg attcgatatg agattgattt tgtctttttt cctgttccgc gatgatttcg 2814841 ttatcctccg cgttatcacg ggtcactttt tgcgtaagaa tcgcaccaac tgctacaagt 2814901 atcataacag cgatgtaata acctttttca ttgagttcca gattatcagc attatagagt 2814961 ccgatactaa acaaaaatac tcccgcaaaa aaagtaaaat aagctagtac tgtaaaggca 2815021 accgtgtttc tgcgtctata tttctgcacc tttgttccct cccgaaagca tagttaaaaa 2815081 gtgataactt ccgtggaata ttatacctca aattccccgg aatggaacaa agaattaaaa 2815141 ataccagtaa aaagggctta ggttgcctcc tttatttcaa cagctgaatc atcaatccag 2815201 ccgataagtt tatcattgat ttggaattgg taccatacag actggccttt ctgtttttta 2815261 gacacaacct ttatgtcttt gccgacgtaa gattgggcag aggtaagcct tatggaccga 2815321 tcatcagtag aaggcttgga ccatacgtct tgaacggcac tgtctttaat agaggcgttt 2815381 aaatccacag atttgaggga tggatttacc tcatcgtact catctaaatc gtatttttcc 2815441 acaatagcgc tgattttgtc agcgtagtca gggtctgtag catatcctga tgtttgcagg 2815501 gcggttgccg cttccttata attccctgcc tcaagcaccg gtttatactt ctttttattc 2815561 cacgatgtgc cacggacgaa caattgggcg tgatcatcca tagattcaaa aaacgtgctg 2815621 tattttcgaa acttcgcgcg aatggttttt cttttccctt tttcaacttc gtccgtttcc 2815681 atcgtgacat gatggccttt ataattccct tttacgccaa aaaggttgtt ggccttagca 2815741 gccagttcac tgttccccca gtccgattcg agaatggcct gagcaattgt gatgctgggg 2815801 agaacatggt atttttcata caaaatttgg gcatgtccgg acagactgtc tataaatact 2815861 tgctgttcat cgatttcttc agtttctttg gatatttcaa tcggttttga taaagttgtc 2815921 gctaaaacaa acagagctag cggaatcgat acaaggaaaa atagtgaaat caagagttta 2815981 cgttttttaa gttttttacg ggccatgaaa accttccttc gaattaaaag attacgaatg 2816041 taaaagaatc taccttttag aattttactt gcacttctaa tatttttcaa ttctttaggg 2816101 ataaagttgg gaaaagattg caaaataaaa accttttcgc tcaatgaaaa ggtttttacc 2816161 atgtttctat ttttgtaaat ttctgagtgc attccgatat tccgtatcat ttattacttt 2816221 atatgatttg acagttgcct tcgacaaacc ttgtgctgag acggccggtt tttccggagc 2816281 tgttttcgct ttatcatgtg gtttatgtgc cagcttgtgc cccattccag tggcattcat 2816341 acaaaatgac aggcagacga gcagcacgct aaggataaaa gaaatgaaga agagatcatg 2816401 ataagcagtc atcatagaat cctgtaccga accgctttgt ctggcagcat cttttttcgt 2816461 gaaaaagccg atgagaatgg gaactcccat atagacaaac aatcttaaaa actgaacagc 2816521 tgtcattctc ttgaccaaat caggcagcgg gcctcccatg gcagctccca tcagccctgc 2816581 ggcgactgtc aggcctgttc ccgctgcaag catgataaac agtgccgcga acatataaag 2816641 agatgatcga tcctgtatat gcagccattg aaaattcaca aaaacgagaa tgagtccgcc 2816701 gataataccg agcatccctg gtccgacttt atcgtataac agagcgctca aaatggccgc 2816761 gatcgccact ccgattaaaa gagtcaagct taaaagaatg agatgctcct gagaaatatc 2816821 atacatttga cggagcaagc cttgaaaagc agaaaggctg acagctaccg ttatcgtccc 2816881 tgcagctatg atcaataagc cgagcaccgg ttttggcagc agcatcagtt taatagatat 2816941 gaaggggttt ttcactttat attccacaat caatagacca atgagcaaac ataacgtcac 2817001 cccgaaacca atccatacat aacccgatga cagcccccat ttttgcagaa aaatgaatga 2817061 aaccgctgag gctgcggcaa ggaagacaga taaaagaatt cccgcacgat caagcggctg 2817121 ttcttgatcc gccgctccgt gatgctcatc atgaagaaag aaatagctca ccgcgacacc 2817181 gatcagggac aaggtgccaa agatgaaaaa cagccatctc caatgcccgc agcttgttgc 2817241 aatggttccc aggattgtac cgatgataac agaaccatag aatcccccga tcagcacaag 2817301 cagtgcatag ttcctgcgtt caatcgggaa tgacagtaca agcattggaa tcataatcat 2817361 cagcatgacg cctgttgccg ccccttgtaa aaagcgccct gccgccatca atgcaatatc 2817421 gcctgaacat gcgatgagca gtgagcctag tataaagaca ggtaatgaag ccagatagac 2817481 gggacgagca ccgaattttt tcctcagcag cggtcctgcc ggaactaaca aggcaaaggc 2817541 catattgccg atcaatatcg gatttactga tgtaaagaca cttgttccaa ccgttttctg 2817601 aacaaggcct tgaactgacg acaatgccgt gttagacatc aatcccggcc cgaccgctaa 2817661 gacggcgagc aaagaaatca cccaatagtg ttttgtcttc atgttgtcat cccttcctat 2817721 atgaatacat gcgaaacaca tcattttttg aaaacaaaag aagctaatag attttgcata 2817781 ccattagctt tcattctaat attctccctt tcaggggaaa tgatattatt ttattataat 2817841 tatgtgaatg aatgagcata taatcaaata ttatttcaaa tcgattgtgt tttgtcaatg 2817901 gagtaaattt caagcacaac atagaaagct tgaaagcttt tccccgatat tgtgtctaga 2817961 actgcactta tgaatccctg ctcgttccct caagcgaatt aaagcaggcc gttttaatcc 2818021 tttcaatcca ctattccaac taataaactc aaataagttg gtgataagac aacattttac 2818081 ccccacattt ttttgtgttc actgggcgtt tgccgcctct aaattgtata tgggtaaata 2818141 ccatgaatta acctatgaaa taccaatgta agggaggcaa aaacgaatgg aactgtatga 2818201 gtgtatccaa gacatttttg gcggcttgaa aaatccatcg gttaaagatt tagcaacgtc 2818261 tttaaaacaa attccaaacg cagcaaaatt gagtcaaccg tatattaagg aaccagacca 2818321 gtacgcttac ggccgaaatg ccatctatcg aaataatgaa ttggaaatta tcgtgattaa 2818381 cattccgcca aacaaggaga caacagtaca cgatcatggt caatccattg gttgtgcaat 2818441 ggtgttagaa ggaaagcttc ttaattctat ttatcgttca accggcgaac acgcagaact 2818501 ctccaattca tactttgtcc acgaaggaga atgccttatt tcaaccaaag gtttaattca 2818561 caaaatgtcc aatccaacat ctgaacgaat ggtgtctctt catgtctact cccctccttt 2818621 ggaagacatg acggtctttg aggaacaaaa ggaggtattg gaaaattcat gattgacaga 2818681 taaactgctc actttgactt cactcaactg gaggattcag agaatgaaac cttttcctca 2818741 aaacaaaaaa acccttatcg aataagggtt taaaggtatg gagccaaggg ggctcgaacc 2818801 cctgacctct acgctgccag cgtagcgctc tcccagctga gctatggccc cgtatgtaac 2818861 gtcatgttta ttatagatga ttttattttg aaaaacaagc tgtttcctct tgaattgaca 2818921 gaaaaaataa ggctcggaaa agagccttat ttttcgactt acatcatgat caaaagtaaa 2818981 atcacaccga gaataattcg atagattgca aatgggacaa gtttgatttt gttaatcagc 2819041 cttaagaaga aacggacgac aaacagtgcg accacaaagg cacagataaa gccgacgatg 2819101 aaaaacggca tcagatccga acttaagctg tcccaatgct tcacgaggct tagaaagctg 2819161 gctcccatca tgatcggcat cgccataata aacgtaaagt cggctgcagc tcggtggttt 2819221 aatccgagaa taacaccgcc ggaaatggtt gaacccgaac gcgagaaacc aggccaaagg 2819281 gaaagacatt ggaataagcc gacggctatc gcctgtttat aggaaatgcg gtcgagtgtg 2819341 tctgtcgctg ttttccgttt attgacccag tcagcaaaaa gcatgaggat tgccccggca 2819401 attaaaccga tggccacagt tttaacggaa aataaatatt catcaatgta atcttcaaac 2819461 aaaaagccga gaacagctgc aggcacgagt ccgacggcaa tttgggcaat gcttaattta 2819521 tgtccctgct cctggtcgct tgtaatattt tttttcaagc ccagtaaatt taaaattcgg 2819581 tctttaaaca cgatagctac tgctaaaatg gagcctagct gaataaccac cttgaatgag 2819641 ttagcagctt cttctgacat cagattactt gattttagcc agatgtcgtc tactatgatc 2819701 atatgtcctg tcgaagaaac cggcgcgtac tctgttaatc cttctacgat tcctaaaatg 2819761 gcggctacaa acaattccca tagagtcatg attttgattc tccccattag acatttattt 2819821 ttttacataa cgggagcttc ccataaatgg aaagcccgtc ttatataact ataaacgaaa 2819881 atcacacttt atgccccggc gtattttcat ttttttcttc atcgtataaa tgtgactgca 2819941 ttttaaacca gtcaaataaa tgtgtcgtaa tgactttggc aaccgcatag ccgggaatcg 2820001 caagaatgat tccaacaacg ccaaacagct tgccggctgt taacagcaga aaaataatcg 2820061 taatcggatg gatgtgaagg ttttttccca taatttgcgg agagatcagc ttcccttcaa 2820121 tcagctgaac aatcgtccaa acgatcacca gcttaagcag catgagcggc gatgtcacta 2820181 tggcaatgat aatcgcaggc gtaatggcaa tcgttggccc taaatatgga acgatgcttg 2820241 tgcaagccgc aatgactgca agcaatgaag cataatccag cccgataatc aaataaccga 2820301 taaacagcaa aaacccgata cagaagctga caatgatctg gcctctgata taagagctta 2820361 accgatgatt catttcgctt aagactgtat atgtctgttc tttcaatcga gtcggcacaa 2820421 acttcagtat gtagaccggt aattttcttc cgtcttttag caaataaaat agaataaacg 2820481 gaaccgtgac gatcgaaatg ataatctcag tcagtgcgcc gataaaattc ccaacaccgg 2820541 taaaggtgct gttcacgatc gtcgctgcct gatccgaaac ctttgtagca agatcagata 2820601 tattaatgtt catcgtttgc tgggcctgat tgacgaagtt gctgccaatc agctgtttcg 2820661 tctgattttc tacgacgtcc acatatctcg ggatattgtc aatcaaactc ataatttgtt 2820721 cttttaagaa gggaatgatc gacacgatcg tgatcgtgat cagcccgata accaataggt 2820781 atagcagcaa tatagaatag attcttctta ttcttcttct ctccagaaaa tcgacgactg 2820841 ggtttaacag ataaaaaaca atgcctgtca aaataatcgg aagtgatatc gttttgagca 2820901 gaacaataat cggggtgaaa ataaatgatg tttttgtaaa tactagaata tttaaaccaa 2820961 tcagcagcag cacaagcaaa aataaaacaa acttattatc caagaagaat cgcttgaatc 2821021 tgccgctcca tgtttgcaac gtctccacta tcgttcctcc gtcatacata gtttaattaa 2821081 attgtacact atcgtcccta taatgaaaaa taaaaaccgt taattgctgg aaaagctttc 2821141 tcggttttaa cattctattt atatctatca tgtgattttg ttctttttaa gctataattt 2821201 agctatatca tgcaaaagga gcgatacgag tgatacgttt tgcaataata ggaaccaact 2821261 ggattacaga ccgctttctt gagtcagcag cggatatcga agattttcag ctgactgctg 2821321 tttattcaag atcggctgaa cgcgctggcg agtttgctgc taaacacaac gctgcgcatg 2821381 ccttctcaga ccttcaggaa atggcggcga gcgattgctt tgatgccgta tacatagcga 2821441 gcccgaacgc tcttcacaag gaacaagccg ttctctttat gaaccatggc aagcatgtgc 2821501 tttgtgagaa gccgtttgct tcgaatacaa aagaaacaga agagatgatc tcagcggcta 2821561 aggcaaacgg cgttgttctc atggaagcaa tgaagaccac tttcctgccg aatttcaaag 2821621 aactgaaaaa acacctgcat aaaatcggca ctgtccgcag atttaccgca agctactgcc 2821681 agtattcctc acgatatgac gcgttcagaa gcggaactgt tttgaatgcg tttcagcctg 2821741 agctttccaa tgggtcatta atggatattg gcgtctattg tatttatccg gctgttgtgt 2821801 tgtttggcgc gccgaaggat gtaaaagcaa acggatatgc tttatcctcc ggagtggacg 2821861 gagaaggaac tgtcattctg tcttacgacg ggttcgaagc tgttctgatg cattccaaaa 2821921 tctctacttc ctatgccccg gctgaaatcc agggtgaaga cgggacgatt gtaatcgata 2821981 cgattcaccg gcctgaacgt gttgaaatcc gctaccggga cggccgcctt gaaaacatcg 2822041 cgatccctga tcctaaaccg gcgatgttct atgaagcaga agaatttgtc acgcttataa 2822101 aagagaataa gctggaatct gaagaaaata catttgaacg gtctttgacc accgcaaaaa 2822161 ttatggaaga agcaagaaag caaatgggga ttgtataccc tgctgatcaa gcttaaaaaa 2822221 atccgcccgc gtgcaaatgc cgcggcggat tttttattag acaatcggag aagatgcctt 2822281 cctttttaaa agcacctgtt gctcatattc tttgatgtca taaagccatg cctcttttac 2822341 cggaacgccc atttgctcac agtaggaatc ccagatggct ccgaaaggat atgttttgaa 2822401 ttcctccatc agggccagcc tttctgtata gcggccctct tcctgcaatt gttttaaata 2822461 tccgttcggg agaagcaggg catacaataa agctttgatc atatttctcg ttccgatggt 2822521 ccaggcggct acacggttaa tgctggcatc gaaaaaatcc agaccgatgg ctaccttctc 2822581 aagagcatga tttcgtacaa tttcaagagc gatttctctc aattcatcat ccaaaaccac 2822641 tacatggtcg ctatcccaac gaacaggccg cgatacgtgc aaggcaagct tgtctgtgta 2822701 aagcagcatg gacgagatct tgtttgatac cgtctcagtc ggatggaaat ggcctgtatc 2822761 aagtaaacaa agcttatgat tcgtcaaagc ataagctaaa taaaattcat gagatccgac 2822821 aacatatgat tcggagccaa gcccgaacag cttgctctcg attgaatcaa gattatgttg 2822881 ttcactgatc tcctctgaga agatccgatc cagtgattct tttagtcttt tacgcggtgt 2822941 cagcctatca ctcgggatat ccttatagcc gtcgggaatc caaatattcg tcaagcaagg 2823001 tgttcctaat tctttcccga agtattcccc gatacggcgg caagcgatgc aatgcctgat 2823061 ccaaaattct ctgatgtccg gatcagggtg tgaaagggtg agtccgtcag ccgctttctc 2823121 atgcgaaaac aaggttggat taaaatctaa accgagacca aggttttttg cccatttcac 2823181 ccagttttca aaatgctgcg gcttcaattc gtcacgttct accgcttccc tgtttgtttc 2823241 tgcgtatatc gcatgcaggt ttacgcggtg ctttccagga atgagagaaa gagccttctc 2823301 caaatctctt cttaattctt caggagtttg cgcttttccg ggataattgc cggtcacgtc 2823361 aattccgcct gaaagctcgc ccttatttac ttcaaagcct tcaatgtcgt caccctgcca 2823421 gcagtggatc gaaatgggca cttgctctaa ttgccgaagc gcctcttcaa catcaattcc 2823481 ccatttttca tatgcctgtt ttgcactgtc ataattggct tttatggtca tacggctctc 2823541 tccctttatc agtttttcaa tccaaataaa aaacttcctt tagatctatc gcaacaggac 2823601 tgaaatccga atttgttttc attaatggcg ccatcgattt ccaccatctt tggcaaactt 2823661 ccgtgtccgc catctttctc catttctctt catcctctat ttctaaatat gcaaaaagcc 2823721 tgcctgtttc ctcgtctaga aaaatggaat aatggtgtgc tccatgagct ttgagtgctt 2823781 ctgccatctc aggccaaatg tcatcatgcc gctgtttgta ttcttcgtac ttgtcttgat 2823841 ggacaaacat gatactggct tttcttttca aaccttttca cctcttcatc atttagatag 2823901 cgctttcaaa acagtttgct gaaatgactg aatgatcgtg cttctatcaa tgtctttagg 2823961 tgtaaacact ttgatcggaa aggaatttct gacgacttgc cgggcttctt ttatgtcttt 2824021 gacttctttg gcagcaatca tttgcatcaa aagatttccg gtggcagttg cctctatcgg 2824081 ccctgcatat accgcttttc cactcatgtc tgccgttaat tgatttaaga aatcattccg 2824141 ggctccgccg ccgatgatat gaaattgctc gatcggtttt tctgtgattg tttcgagctc 2824201 tttgatggct atcgcataga tgatggctaa attgctgtag atgcagcagg caagttcgcc 2824261 tgcagtacgg ggaatctttt ggcgggtttg tctgcaataa tgttgtattt cctttatcat 2824321 gttttctgga ttcaggaaac gtttatcatt taagtttata aattgctgga atggttctgt 2824381 ttttttggct tcttctgcaa gctgctgaaa agaataatct gcttgtagct gctgtttgac 2824441 ttcttgtatc acccacatgc cgataatgtt tttgagaaag cgaatggtgt tgtttgcgcc 2824501 gcgttcattt gtatagttgt tttctaaagc aagatcagtt attatcggtg ttttgttttc 2824561 aaccccgatt aacgaccatg ttccgctgct gatatacgcc cagccatcat ttacgcctgg 2824621 cgccgcaatg acggccgagg ccgtatcatg tgttgcgact gtcatcacct tgcacgccgg 2824681 gagatcataa tccgggaacc actcatttct tagcttcccg agttcacacc ccggttcagt 2824741 gagcggcgca aattgctgtt ccagaacaga cacggcttca agcaattcag gatcaagatt 2824801 tcccgttgag acgtttaaaa gctgtgttgt ggacacgttt gtgatttccg ttacagcttt 2824861 tccggttaaa caatagccta aataatcagg aatcatcata attttgtctg tctttttcag 2824921 cagctcacgg tcttcttcaa acaattgata gatcgtgttg aaaggctgaa attgtattcc 2824981 tgttttttga taaattgcgg cttttgagag ggtatgttcc agtttgtcta ttgtgtgatc 2825041 tgttcttcta tcacggtagg agattgcttc ccgcaaccga tcgccttttt cgtccagtaa 2825101 gacataatcg actgcccatg tatcaatgcc tacggtgcag tgttcatacc caagcgtctt 2825161 tactttttgc agtccttgca ggatttgttt tagcaaatga tcaatatccc ataagcaatg 2825221 cccgtctctt tgactgaaac cgttagcgaa cctgtgaatc tcttgtatgt caagcttccc 2825281 ttcattcagt tcacctacca tgattctccc gcttgatgcg cctacatcaa tggcagtata 2825341 aatcatcctt tcaccctctc ttcgaaagag gaacagctgt caccttcacc tttttgtcct 2825401 caagagcttt taccgatgcc ggatcaagtc cagaatccgt aataaggcgg ctgacatctt 2825461 gcagcgaggc gatatgtgaa aactcgcggt tcccccattt gcttgaatcg gccatcaaaa 2825521 tggtctggtc cgacctttcg atcatccgtt ttttgagcag cgcctgccac tcatttgaat 2825581 cactcatccc gttgtgtacg tcaaatccct tacatgacag aaaggtttta ttgacatgat 2825641 aggtctcaag tgaacgctct gctaacgggc cggcaaatga taatgatttt tccagcaaaa 2825701 tgccgcctgt tgaaatgact gatatgtttt ctttattgct gagttcaata gctgctttca 2825761 ttgagtttgt aatcacggtg agctcaatgt cagggagtat ttttgccatg taccaagcgg 2825821 ttgtgcttgc atcgagaatg attcggtctc cgctttttac atatttggcc gcttcgtgag 2825881 cgatggcttt tttttcgatg acattcgtga tttcccgttc agaaaaatga atttctgatt 2825941 ccttctgctg aatactgacc gctcctccgt ggctccggct cagtttatgt tctttttcaa 2826001 gcttttcaag atcacgccga atggtttcct ctgtgactga aaaaatgtca cttaattcgg 2826061 aaacgcggat gcttgaacgc atatttacta tttccactat tttttgctgc cgttctgcta 2826121 ctagcatcgg taacgccctt cctcatatcg tagtccgtct tatattttta tcatagcata 2826181 tatctaacgc gtaaaagcag cagggacgcc gccgtctacc gtgatcatgc agcccgttgt 2826241 tttttcggct ttggaagaag cgaagaatgc aatggcttcg gcaatatcct ccgggtaaat 2826301 attgacgagc aatgctgtcc gtttccggta atgttcctcc agctgatccg gttcaatccc 2826361 gtacgccgcg gctcgttcct cacgccagct tgaaccccag attgccgatc cttgaagaac 2826421 tgcatcaggc aaaacggagt tgaccctaat gccgaattct ccgccttctg ctgcgatgca 2826481 tcttgctaaa tgggtttcaa gcgccttaac agagctgtag gcagaggcgt tttttcccgc 2826541 ataaactgaa tttttcgatc cgacaaatac catgcttccg cctctatttt gatgtttcat 2826601 ctgtttaaac gcttcacggg ctacaaggaa atagcctgtt cctaaaacat tcatattaag 2826661 attccattct tttagacttg tttcgtcaaa tgggcttgat gtggccagcc cggcattatt 2826721 gacgacgata tcaatgccgc cgtaagcaag cgccgctcgt tcaaaagctg actgtacgtc 2826781 ttcctccttt gtcacatcca ttttgacagc cattgcccgt ccttttccgt atgcatcgtt 2826841 tatttccccg gcaattttct gtgcgccttc tatattcaga tcagctacga tcacgtgccc 2826901 tccctcagct gcaaatcggc ggcatgccgc actgccgatt ccgccggctc ctccagttat 2826961 cagcgctact tttcgggaaa attctgcttc cggcggggcc agcgtgagtt tatatagttc 2827021 gagcggccaa tattcgacat ggtaggactc attttcatgt aaagaaacaa attgccccag 2827081 agcggttgct cctttcatta cggcgatggc cctccgatat aaagccccgc ttactttaga 2827141 catcgcataa ctttttcctg tattcaccat tccgattcca ggaatcaata tcacccgcgg 2827201 ggcggattca aagatttgat ccccatcctg ctgattgcgt gtaaagtaag cctgatactc 2827261 tgatgtaaag gtctcgactc ctgacttgat cagatctgca agcttgtgca catcttgagt 2827321 ttccggattc caatcaatgt acagcggaac ccgttttgtg tgaacaaggt gatccgggca 2827381 tgccgcaccg atttgcgaaa gtgctggcgc ttggacactg tttacaaatt ccaagacatc 2827441 gtcatgatca tcataggaaa ggatcatttt cttttcttca cttactgctc ctctgatcac 2827501 aggcatgatg cctgccaaga tttgttttct tttatcctcc ggcagcggct gatacctttt 2827561 gcctccgaat acctcatgct gattgatacg atcgttaata tactgctcgg cttcttgaat 2827621 gatggatatc gttttttgat aacatgtttc agacgtctct ccccaagtga ctaagccgtg 2827681 tttctccatt aatacaagct cggcgtgggg gttgtttgct acgccttcag cgatcatttt 2827741 agacaaagta aatccaggac ggacgtatgg cacccataca aaccgatttc cgtaaatgtc 2827801 ttcagcgatt tgttttccat tatccgcaca gcatatgctg ataatcgcat ctggatgggt 2827861 atggtcaaca tgtttgtatg gcagaaaagc gtgtaatagc gtttcaattg aagggcgggg 2827921 atgtttgctg tctatcatac aatgagacag gtagtctacc atttcttcat cgggcatttg 2827981 gtccctttta atcagcgggc ggatatcatc taatttcaaa ccggaaaagt tatgcgcttt 2828041 cattgttgcc aaatccgatc cgcttccttt tacccacatg acttctattt cacggcctct 2828101 aaaatccttt tccgttgttt tcatagatgt attccccccg ccccagttgc agacagtgcg 2828161 gtctgacccg atcagattgg acctgtacac caattcctct acacctttag gtagctgtgc 2828221 agctcgctct gaatcccata tatgtttcac catatttgat attcctccat acccttttat 2828281 ttgtatccgt tttcattata tatgatttct gtttgttttt gaatcgtttt tgtttatttt 2828341 tgctttttaa caaaaaaaga aagcagcaga tatgccgctt tctcgtttca ttatgattct 2828401 attttaaatt tcttcgtaat gtcctgaagt tcttccgcca tgtttgccaa cgtttccgct 2828461 gaagagctga tttcttccat ggacgcaagc tgttcttccg ccgaagctgc gatatcctga 2828521 atgcctgctg agctttcttt cgccactgca gaaatatctt caacagcact tgacacttcc 2828581 tgtgatccgg ctgacagttg ttcaaccgtc gcgttcaagt tttgcaattc gccggaaatt 2828641 tgggttgtca tctcatagat ttgtttaaag ctttccgctg tttgatccgt aatctgcaag 2828701 ccttctttca cttcatgatt cacggattgg aacattgaaa gtgaggtgct gatttccctg 2828761 acaatctctt gaattaatcc ttcaatttcc ttggcggagt ctgctgattg tacagcaagt 2828821 tttctaacct cttccgcaac tactgagaaa cctcttccgt attctcccgc tcttgccgcc 2828881 tcaatcgcag catttaatgc aagcaggttg gtttgatcag caatgccgtt aatcacattc 2828941 aagatgcttg tgatgtcttg cgattttgtt tcaaggccct tcacaaccgc ttccgctttt 2829001 tgaacggatt ggtcaattgt tttcatctgg ccgactgtat gctccaccag cttttctccg 2829061 ctgcccgctg cctcagagga ctgaatcgat gatttcgtaa tggttgaaga ggcttgagcc 2829121 acttttgaaa tcccctcgtt catttgagaa agatgatttg agcttgtttc cagtttctcg 2829181 ctttgtgcct cgttgccatc tgagaactgt tcgatggcaa gtgtaatatg ttcagttgcc 2829241 ttgcttgttt gggctgcgct tgctgtcagc tcctcagaag atgaagcgac gttttctaca 2829301 gacgtttgaa taacgcctat tacagaacgc aatgatgcag acatttcatt aaagctttcg 2829361 ccaagctggc caaactcgtt tttcgagtga atgtcaatga cttctgtgag atctccgctg 2829421 ctgatttttg cagacgttga gacaagtttt cttaacggct tggtgatggc acggataata 2829481 tagagtatga gtatgccgcc gattactatt gacacgcata gaatgataac cgcagtgttc 2829541 agcaccgggc ttgaagcatc ttgcaattca ctgacaaaat atgtgcccgc gattttccag 2829601 ccagtcagtt tatttgtcgt aaaggccatt ttcttttctt tgccttcgaa tgtatattca 2829661 aatgagcctt cttttttgga atatacttgg tttgtccaat cgccggaacc ggttgtcccc 2829721 ggcttaatgg tcggatgggc gatatatttt ttgttgcctg tcgtaataaa tgcaaagcct 2829781 tcttttccga ttttgattct ttttgatgca gtaagcactt catccaggtt taaatctagc 2829841 gctataaccc ctgaaccgtc ttttaattgt tttgaaattg tgacaacgat atctcctgtc 2829901 gcttcatcgg tatacggttc tgagaaaaca gcttgtcctt tttccgcaac cgcctgtttg 2829961 taccagtcac gtcctgtcgg atcgaaacct ttcggaacac cgctatccgg atatttataa 2830021 agcttcttat cttctgaggc agcatagatt gcgcctacat cgtcgttaag tgtcgtgtac 2830081 tgcttaaatt tctctttcag taatgttttg tttttgccta acaatatgtc tttatcgact 2830141 gtctcactat aataatctat tgcttttact ttatcttcta atttattttg cagcgtactg 2830201 tttagttctt caacatttcc cttcgcactg cttatgagct ctctgtctaa cgcgttccaa 2830261 gctgattgat aactgaaata tgctaaaacc ccaaccggca aaataagcac tgccagaaac 2830321 gcagcgatta gcggtttgct gatcgatggc tgtttgatcc attgtatgaa ttttcccatt 2830381 ctcgttgact cctcctttaa gataaatcta atatcgtcaa actaggataa aaggtttaat 2830441 aaaaaaacta aaaaaaacac ccaagcgcaa caagcttggg tgttaaggct tattattcaa 2830501 ttttaaatcg tttggtcata tcccgaagct cttccgccat agaggaaagg gtctctgcag 2830561 acgagctgat ttcttccatg gaagctagct gctcttcagc tgacgccgcg atatcttgta 2830621 tatgcgctga gctttctttt gaaatcgatg caatgtgctc agacgctccc gaaacttctt 2830681 cggagctggc agaaagctgc tgaaccgtcg cactcatatt ttgcagttcg ccggcgattt 2830741 ggttcgtcat ttcagaaatg cgtttgaagc tcatttctgt tttatctgtg atgtcaagtc 2830801 ctgtctgcac ctcttgattg acagattgga acatgccgag tgatgtattg atttccttca 2830861 caatttcgat gattaatcct tcaatctctt ttgctgaatc tgctgactgt actgccagtt 2830921 ttcttacttc ttccgctaca acggagaagc cgcggccgta ctcgcctgcg cgcgctgctt 2830981 caattgctgc gtttaaggca agcaggttcg tctggtctgc gatgccgttg atcacacgca 2831041 aaatgtttgt aatatctttc gatttcgttt ccaatccgcg tacgacttgc tccgcttctt 2831101 taacggactt gtcaatgaca ttcatttggc cgacggtttg atgaacaagc ttgccgcctt 2831161 cacttgcaat ttctgtcgat tgaacagatg aatcagtgat cacttcagaa gcttgagcca 2831221 tattcgtcaa cccgtcattc atttgataaa tgtgctctgc tgccgtttca atgttttcgt 2831281 tttgtttttc attgccgtta gaaaattgtt caatcgccaa tgtaatgtgc tctgttgcct 2831341 tgctcgtttg cgcagctgat gcagtcagct cctcagagga agcggcaaca ttgtctaccg 2831401 aatcctggat ggcgtgtatg agagaacgaa gtgacgacgc catattgtta aagcttttgc 2831461 cgagctcgcc caattcatct tttgaacgga tatcaatggt ttccgtcaaa tctccctcgc 2831521 tgatccgctt agaggaaccg acaagctgtt tcagcggtgt tgtaatcgac cgaatgatca 2831581 atgtcatgac gataatccct atgataatag ctgcggccaa gacaattaaa gcaaggtgaa 2831641 ggacaggctg ggctgcctca tggatttcat ccaaatacat ggtgccgccg atcttccatc 2831701 ccgtcaactt gtttgtgtca aaggccattt ttttcttatc gccatccatg gtgtattgaa 2831761 aatcgccttt atcagcactc aacatcttat cgagccagtc gccttttaat tcagttcctg 2831821 attgttcatt agggtgtgcg acaacttttt tgtccttcgt catgataaat gcgtagcctt 2831881 gtgtgccgat gttgactttt ttggttgttt tcagcagatt ttcaatcgtc atgttgattg 2831941 cgataacgcc tgaaccatct tttgtctgct gggcgattgt cacaaccatc gtatttgtcg 2832001 acgcggtttt ataagggtct gtgatcacga ctttcccttt atttgcaacc gcttttttgt 2832061 accagtcgcg ttcaaccgga ttatagccgc ttggcatcgg aagatccgga tagcgggtaa 2832121 agtgcccttt tgtgtcactt gtataaatgg attctacatc cttgttaatg ctgatatatt 2832181 gtgagaattt ctctgcaatg cttgcattgc tttttgcatt gtatttctct tttgtcagcc 2832241 attcgctgaa ataatcagca ctgttttctt tttcgccgat gctggtgtta atgatttcgt 2832301 ttaattgctg tacattttcc aatgcgctcc ccatcatctg tctgtcgagt gagctgctag 2832361 ccgattgata cgcaaagatc gccaatatga caaccggtat gatgaggatc gacagaaagg 2832421 aaacgagaag cttccgtgta attgatcttt gttttatgag ttggagtatt tttttcatca 2832481 ttcatttctc cttttttatg ctacccttca tatcggctgg aaatgggtaa atatatacag 2832541 caaaaaagaa gaaatttaac aaaagtaact aatttcccat aaataaatag tattttagac 2832601 ctattatttg tctactttaa attgttttgt cagatcacgg agttcttcag acattctttc 2832661 aagcgtcagt gcagatgaac taatctcctc catggatgcc agctgttcct cagctgaagc 2832721 ggcgatatct tggatgccat ccgagctttc cttagaaatg gcagtgatat catttgaagc 2832781 tgcggaaatt tcttgagctc ccgctgacag ctcctcaacc gtcgcattca tgttttgcag 2832841 ctcggaagca atttgattgg tcatttgcga tatatgtttg aagctctgtt tagtttcatc 2832901 cgtcatgaca agccctgttt caacttcttt gtttacggac tgaagcacgt tcagtgatgt 2832961 gtgaatttct tttactattt cactgatcag cgattcaatt tcttttgctg agtcagccga 2833021 ctgtaccgcg agctttctca cttcctcagc gacgactgag aagccccggc cgtattcacc 2833081 cgctctggca gcttcaatgg cggcatttaa agccaaaaga ttggtttgat ccgcaatgcc 2833141 gttgatgaca cgcaaaatat tcgtgatatc ctttgatttg atctccagcc ctttcaccac 2833201 ttgttccgct gcttttacgg aatggtcaat tgtgttcatt tggccggctg ttttctggac 2833261 gagtgtctcc cctttgcttg acacttcggt tgaatctgcg gatgtttctg taatcactgc 2833321 tgcagcccgc gccagctctg ccaatccgtc attcatttca ttaatttgtt cggttgtcgt 2833381 ttctattttc tcgctttggc tttcactgcc gtttgaaaat tgctcgatag ccatcgtaat 2833441 gtgctcagtg gctctgcttg tctggtctgc cgatgcagtc agctcttcag acgaggaggc 2833501 aacgtgttct actgagtctt tgatcccgtg aatgagcgag cgaagcgagt gtgccatatg 2833561 attgaagctc tcactcagaa cgccgagttc atcttttgaa ttgatttcaa tcgtttcggt 2833621 tagatcgcct tcactaattt tttcagcgga tgcgacaatg cgtctcaatg gctttgtgat 2833681 ggatcgaatc acaaaataaa tcgccgtcat tccagctccg atggcaatcg ccagaacgat 2833741 tgaagccatg atcagaaccc tgcttgcagc atcgtgaatc tcgtttgcat acatcgtgcc 2833801 gctgattttc cagcctgttg tttggcttgt tgcaaatgcc atttttttct ttttgccttt 2833861 gtacgtatat tcaaagtccc cgcttttatc cttgtagagc ttatcaaccc agtccccttt 2833921 tagctctgtt cccgcttttt ctccggagta ggcgatgact ttcttgtttt ggctcaaaat 2833981 aaaagcatag ccttcttttc cgatattgat tcctttcgcg gtagtgacta agtcatcaat 2834041 tttcatatca atggcgacaa cgcctgaccc atccaccgtt tgacgggcga tggtgacgac 2834101 catttttcct gatgaaatcg attcataagg ctcagtgaca attgttttgc ctttattggc 2834161 cattgcttct ttgtaccaat ctcgttccaa agcattaaag tcgcttggca tgtcagcgta 2834221 cggataacgt gtgaagtccc cgtctttgcc gcttgaaaat accgcagcga cattatcatt 2834281 catttggata aattgtttaa attcctgttt cagctctgtt ttctttttat cctgaaattt 2834341 ttctgctgta gcccaatcgc tgaaatatgc gaggcttttt tcagtagtgc tgattttatc 2834401 atcaatgatg tgatctaata tctgaacatt ttcctttgcg ctttgcgtca tctgtacatc 2834461 aagtgaggca actgctgatt gataagcgct aaccgaaagg gcggttatcg gaacaattaa 2834521 gatcagcagg aaagaaataa taagtctcct tgcaattgat gatctgcgaa tagtggtgag 2834581 tgtttttttc atttcctttt gaaccttctt tcaataattt acaaattata tcggcggatc 2834641 ttcctttaaa ttacattgaa aatggaggaa aaaatgaaaa atagttctaa attcacctgt 2834701 taaactagga ctttattatt gtttaccata taaaaaaaca gcgctttgat agcgctgttt 2834761 ttcggttttt actcgatttt aaattgtttc gtcagatcgc gaagctcttc tgccatctgc 2834821 gcaagagtcg tcgctgagga actgatttct tccatggaag caagctgttc ttcagctgat 2834881 gcggcaatgt cctggatgct tgccgagctt tctttcgaca cgtctgcaat gccgctgact 2834941 gctgctgaaa catgctgtga acggtctgac agctgctcga cggtggaatt catcgtctgc 2835001 agcttgcccg cgatttcgtt tgtcatgctg aaaatgctct ggaagctttc ttttgtattg 2835061 tctgtgacaa caagtccgga ctgtacttcc tgattgacct ctttaaacat gtgaagagag 2835121 gtgtcgattt ctgcgacgat ttcttggatc agcttttcga tttctttcgc tgaatcggct 2835181 gattggacag ccagcttgcg cacctcctcc gctacgacag agaagccgcg tcctgactct 2835241 ccggcacgcg ccgcttcaat ggctgcattt agtgcaagca gatttgtttg gtcagcgatt 2835301 ccgttgatga ctctcaaaat gcttgtgatg tcttttgatt ttccttctaa gcctttgaca 2835361 acagcttcag cctgctgaac agattgatta atcgagttca tttgtccgac tgtctgctgc 2835421 acaaacttct cacccgttcc ggcgatttcc gttgattgga tagatgcctt tgtaatatct 2835481 gacgatgttt gtgagacttg ctggagtcct tcattcatta agttcagctg atgagagctg 2835541 gattcaacct tttcgctttg ctcctcgttt ccgtttgaga actgctcaat cgccatcgta 2835601 atatgctcgg tggctttact cgtctgcccg gcagatgcgg taagctgttc ggaagatgcg 2835661 gccacattgt tcaccgagtc ctgaatagcg ctgatcagag agcggagaga ttgtcccatt 2835721 tcattgaagc tttccccaag ctctccaagc tcatcctttg aatggatttc gatcgtttcg 2835781 gtcagatccc ccctgctgat cgttttcgat gattgaacaa gacgttttaa cggttttgta 2835841 atcgaacgaa cgataaacag aattaaaatt ccgcctgcca caatggaagc aatcagcaca 2835901 atcattcctg ttgtcagcac agactttgag gcatccttaa tttcatccat atacattgtg 2835961 ccggctattt tccaaccagt cagttcgttt gtagtatagg tcatcttttt atcttcgtta 2836021 ttaagagtat actggagttc accgctgtca ttcgcataca ttttggctac ccagtcgcct 2836081 gaaagctttt ctccagcctt atggttcttg tgggcgacat aggttttgtt ttttgttgca 2836141 atgaaagcat aaccttcttt tccgaccttg atttgtttca tttgttctaa caatttatca 2836201 atggtaatat ccatggcgac aacgccagat ccgtccttca gctcctgtgc aatggtaatg 2836261 accatgcttc cgtcactcgc agccacgtaa ggatctgtca cgacaatttc accgccggcc 2836321 ttcatcgcat cctggtacca aggccgttgt ctcgggtcgt atccttccgg caatttttct 2836381 tttggcgctt gtacataagt gccgttatct gcgcccccat aaattctggc tactccttga 2836441 ttaatagata catattgtga aaatttagct ttgatctctt cttgatttga tttccctttg 2836501 aatgcggatc ttttaagaga ttcactgaaa aaggtgactg ctttcgcttt ttctcccaga 2836561 tcatttgtaa cagttgtatt aaatgtatcg acactgtttt tcgcatttcc cataatttcc 2836621 tgatccagct ttccgctggc gcttcggtaa gagctaaatt ctaatataag aatagggata 2836681 atgagaatcg caataaatga gacgattaat ttctttgaaa tagacggttt cttcagccaa 2836741 ttgataaaag tcttcatgtc acttgctcct tcaggtttga tacagtatat atcggctgct 2836801 taaaaaagtt ttaaaataaa aaatggaaga agttcttttt ggctgtcttc tgccttttta 2836861 actttcattg cccaagctct ttgcatatct tataaaaaac aaggggggct aaacatgatt 2836921 attgtatcag gacaattgct ccgtccccag gatattgaaa attggcagat tgatcaagat 2836981 ctgaatccgc tcttaaaaga gatgattgag acgcctgttc agtttgatta tcattcaatt 2837041 gctgaactga tgtttgagct taaactgcgg atgaatattg tagcagcggc aaagacgctg 2837101 cacaaaagcg gggcgaagtt tgccactttt ttaaaaacat acgggaatac aacgtattgg 2837161 agggtttcac cggagggcgc cttggagctg aaatacagaa tgccgccttc aaaagcgatt 2837221 cgggacattg cagagaacgg cccgttttat gcgtttgaat gcgcaaccgc aatcgttatc 2837281 atttattact tggccttaat cgatacaatc ggagaagata aattcaatgc cagctttgac 2837341 agaattattt tatatgactg gcattatgag aaattgccga tatatacgga aacaggacac 2837401 cactttttcc ttggagattg tttgtatttt aagaatcctg aatttgatcc gcaaaaggcg 2837461 caatggagag gcgaaaatgt gatactactg ggggaagata aatattttgc ccatggtctt 2837521 ggaatcttaa acggaaagca aattattgat aagctgaatt cttttaggaa aaaaggagcc 2837581 ttacagtcag cctaccttct gtctcaggcg accagactgg atgttccgtc tcttttccgc 2837641 atcgtccgct aaaaagcccc atcgcctatt ttccggacga tggggtttca aatgcctttc 2837701 gttttcgata gaagggggct gtgccaaaat attggttcgc agcccactcc attttttcaa 2837761 ggtcatttct tgtcacgatt ggatcctggc tgctccattt gataaagcgg acaaaatagt 2837821 agcctttgat aggaaccatt gtaacttttg agtgaggcca gccttcaaat acaaactcaa 2837881 ttttccctct ttttttataa gaatattgaa gaatgttcat atctgtcacc tcagtttatc 2837941 aagttacgtt cggcaaagct cggtacgttt acatccattg attaactatc cctcatgcag 2838001 gctttccgga aaacaaaggg tgaggcgcgt gtctctttcc ctcgcttttt atttcgcata 2838061 tggacgaatg ccaagcacgc cttcattcga taaagccgca gcgtgggcgg gtgtgacaag 2838121 ccctccggct atcggcgctt gttcagcgat catgcttttg tcataaaaaa cagcctatta 2838181 tcccatcatt ttgatatagc atgtccgggt gcgaggcccg tcaaattcgc agaaataaat 2838241 gccctgccac gttccaagaa taagccggcc gttttccaca atgacatgct gtgaagctcc 2838301 gaccgtactc gacttcatgt gtgcagctgt attgccctcc atatggcggt ccagctcatg 2838361 ttcccacgga tatacctcat caaaccttct gagcatatct tttttgacgt ccggatcggc 2838421 attttcatta attgtaatgc ccgcagtcgt atgcggacag taaatcagcg ctgcgccgct 2838481 cgttatacct gtttcttgaa gaaacgcttc cacctcccgg gtgatatcta tcatttcatc 2838541 tcgtttggtt gttttgattt gcagtgtttt cagcatttgt ttctcctttc gtttgtccgc 2838601 tctcatcgct taattcgttc tgtgttcttt tttttcctgt taaaccgctc tcataaaccc 2838661 gataaaacaa aaaaactcca gtctaaggct ggagtttagc accatagata tattcttgct 2838721 tcatacggct ttaagagtac tgatgtcata tgcttgtgcg gctctgtttc aatatttgac 2838781 aagacgagtg catctgatga caatggcaat ccagagtgcc tgaacaacgc cggtgttcct 2838841 gtcagattgg ccgcaatcag tgcagtatgg ctctcgtttt tccgaagata tgcaaagatt 2838901 tgctgatctt ccggtaaaat gagctcgtat gtcccgttaa taaaaacatc atatgtttgg 2838961 cgcagcttga tcaagctttt gtaaaaatgg taaacggatg ttttatcgtt tttttgcgcc 2839021 tcggcattca gccatttgta attctcattg attccgatcc acggtttggc ctcagaaaat 2839081 ccggcgtatg gaccagcatt ccattgcatc ggcgttcgcg aattgtctct tccctttttc 2839141 cagacaatct tcatcacatc ctcgtgtgat gtgcctttcg ctgtttttgt ttcatacagg 2839201 cgtttcaatg cgacatcatc atagtcctca atagatggaa aagccacgtt cgtcatcccg 2839261 agttcctgtc cctgataaat aaacggtgtg cctttcatga gaaaataaac agcggaaagc 2839321 gcttttgcac tttctttcag gtacactccg tcgtctcccc acacagaaac tgaacggggc 2839381 tggtcgtgat tctccataaa caaagcattc cagccgatcc cttccagact gtcctgccag 2839441 tcagttaaaa ttcgtttaaa tgcaacgata tcaatacttt cattgatctc tacatcccac 2839501 aggccgagat gctcaaattg aaaaatcatg ctgaatatgc cgtttttttc tccagcccaa 2839561 tcagctgctt cttttgcagc gacgccgttt gcttcaccaa ctgtcataat cggatagcgg 2839621 gaaaatgtgt tttccttcag ctctgttaac aaatccataa tgccgtcagc attcatatga 2839681 taaggaaagg aagggacata gtccagtccc tttggattcg gcatgtcagg aaacccttct 2839741 tttttcttaa tatgcgtaat ggcatccacc cgaaatccgt caattccttt atcaagccac 2839801 caattgatca tgtcataaac ggcattcctc accttttcat tttcccaatt caaatcaggc 2839861 tgttttttat caaaaaggtg cagataatac tggcttgtct tttgatcata ctcccaagcc 2839921 ggcccgccga aaatgctttc ccaattgttg ggcgtttttc cgtttttgcc gtctttccaa 2839981 atataccagt cgcgcttttc cgagtgtatg gatgaacggg attctatgaa ccatggatgt 2840041 tcgtcgcttg tgtggttcac aacgagatcc ataatcagct tcatatccag atcatgaatg 2840101 tcaccaagca gctcatcaaa atcttccatc gtgccaaact cgcttaatat gttttgataa 2840161 tccctgatat catagccatt atcggcattc ggtgaatcat acagcgggca aatccatatg 2840221 acgtcagcgc ccagctcttt tatgtaagaa agcttggttc tgattccttg aatatccccg 2840281 attccgtcgc catttgaatc tttaaaactg cgggggtaaa tttggtaaac tacggcttcc 2840341 ttccaccaag cctttttcat acagccactc cttcccagtg taccgttctt atatatccta 2840401 tgtagaaaaa ggtctttaca gcattgcttt ttaagaaatg acttgatgac acaaaaaaca 2840461 gccgtttgtt ccccggctgt tttttatcaa aaatcagttt tttttatttc tacaaaacgg 2840521 atgtggtgat cttcggcgtc gaggatttta aattcacagc cctccgcgtg tatcacatcc 2840581 cctgctttca gctccatttt ttgcgttaga agccagcctg caatcgtatc aatttcttca 2840641 ttttcaatcg caatgtcgag aaggtcattc acttcgtcta ttagcgcttt tccatccatc 2840701 acataatggt gctcgccctt tttcaggatg tgcggtgttt catcctgatc atactcatcg 2840761 cggatttccc cgacgatttc ctcgataata tcctctacag tgacaagccc cgccgttccc 2840821 ccgtattcat cgacaagaat cgccatgtga atccgctcct tctgcatgcg gattaaaagc 2840881 tgctgaacag gaatgctttc aatgactctg ataacgggcc tcatgatttg attcagcttt 2840941 atcggctggc cgagaaaata agctttaaac atatctttgc tgttgatgat ccctaaaata 2841001 tgatccttgt catctttgat gacagggtag cgtgtatacc gttcattaat gatgtgatga 2841061 attgcctctt caagcgactg ctccagagag ataaccgcaa tttctgtccg cggaatcata 2841121 atctctctcg ctacccggtt gtcaaattca aaaatcttat ttacatagcg gaattcagac 2841181 tgattgattt ctcccttttc atagctttca gaaaggatca gccttagttc ctcttcgctg 2841241 atgacaacct gatgctcctt taccgaatga aagccaaaca atttcacaag aaaacttgca 2841301 gagccgttta atgctttaat aaacgggtac gtgattttat aaaaccagat cagcggcttt 2841361 gcaatccata agcttacagc ttcagctttt tgaatagaaa ccgttttcgg ggcaagctcc 2841421 cccatcacca catgcaaaaa agtgacgatg ataaatgcaa ctacaaatgt gacaatgtgg 2841481 ttaaacggtt ccggtatgcc tgtcattgta aataagggat gaagaaaacg ttcaaatgta 2841541 ggttcaccaa gccacccaag gccgagggct gtaatcgtaa tcccgagctg gcaggctgat 2841601 aaatactcgt caagattgga gatgatttta tgtgcggcta gtgctcggct gtcaccgctt 2841661 tcgatgagct gattgatttt tgaacctctg attttgacga tcgcaaattc cgctgcaacg 2841721 aaaacagccg taatgccaat caaaacaaaa atggcgatca attgtaaaat aagcaaaaaa 2841781 agcccttacc ataaatggta aggggccacc tccttaacgt taattctcat cacgaccgtt 2841841 taagaaaatc atcacaaaac gaagtagttc aaacagggaa accagggcgg cggccacata 2841901 cgttaaggca gcagcactca gcactttatt taccccattt tcttcattgt ttcggatgaa 2841961 tccttctgac acaataatct gcttcgcacg tgaacttgca ttgaattcga caggcaatgt 2842021 aatcagctgg aaaaagacag ccgctgaaaa cagtatgatg ccaagcccga tcaaattcag 2842081 gctgccgaga agcatgcctc ctaagaaaag caaaggagct acaccggatg caaaattcac 2842141 gactgggaag attttatgtc tcagcacaag cgcaccatat gactcctgat gctgcaaggc 2842201 atgtccgact tcatgggaag ctacggatat ggcggaaatt gagcggccgt aatagaccgg 2842261 ctcagataaa cgcaccaccc gtcttgtcgg gtcgtaatgg tctgttaaag tgcctcttac 2842321 cggttcgacc ggcacgtcgt aaagaccgtt tatatctaaa atccgtcttg ccgtttctgc 2842381 ccctgtacgt ccgcttgagg cttccacttt tgaatatttt tcaaagttgc tctttacttt 2842441 aaattgtgcc caaaacgaca atcccaatgc ggctattgtt aaaaatataa acagcatttt 2842501 ttcatcatcc tttgttcatg atcatttctc tattacgatt attttaatga gttttctttc 2842561 tcgtgtacag aaatgcgctt tttcttccgg cttggagcac acaatccaat cagcaaaaag 2842621 aacaggcctg ctgaaaacaa ataaaaggcg aaactgccgg ccagttcttt cagaaaatga 2842681 agccaggaga agcttccgga aaagtgatta tatgaattca aatcgaaaat aaacaaaatc 2842741 accgcggatg ccgccagctg cgtaccgatt aaaaccacga tcgttctttg aaagatcgtc 2842801 atctttttca tcctttttgt tttagtttat ggagaaatcc ggttttatat gttttgtaca 2842861 ttttttgaaa aacatcaccg gaagtgggac atactgttag aaaaaagcac gggtgtgatg 2842921 gaagctatga aagtgacgag tgaggaaaag gaacagctga gcacagcaat cgaccgaatg 2842981 aatgaaggac tggacgcgtt tatccagctg tataatgaat cggaaattga tgaaccgctt 2843041 attcagcttg atgatgatac agccgagtta atgaagcagg cccgagatat gtacggccag 2843101 gaaaagctaa atgagaaatt aaatacaatt attaaacaga ttttatccat ctcagtatct 2843161 gaagaaggag aaaaagaatg aaatcaaatc ggatatttat ttcatggctc aggtggccgt 2843221 tatttatccg aatcggggtt attattttat gtctgattct tttgttcggc caaatcattt 2843281 atatacttga gcctaagcag ttcacttcgg tattcgaagg tatttggtgg gctgtcgtta 2843341 cggtttctac agtcggttat ggagactatg tgccgcacac tccgctggga caggcagccg 2843401 gaatactgct gattttgagc ggagcaagct ttgtcacagc gtatttcgct acgttatcag 2843461 cggccgcatt cagcagacag catcgctaca ttgaaggaaa agttgcttac aaaggccggg 2843521 accacatcat tctgatcggg tggaatgaaa aaacaaaccg gcttttgaag gaccttcagc 2843581 ttgccgcccc ttccaaaaca gtcgtactaa tcgatgaatc cttaacagaa ggcccgctta 2843641 ttgaaaacgt tcatttcata cgcgggcacg ctgccgatga tgggacactg aaacgggcca 2843701 atattactga agcggaatca gtgatgatta ctgccgatca gtataaaagt gaaactgatg 2843761 ctgatatgct gtcagtgctg actcttttat ctgttaaagg tcttaatccc cttgcttact 2843821 gcatcgtcga gattttaact gaccgttttg tcaccaatgc ggaacgggca ggcgcaaacc 2843881 aaatcatcgg aacttcagaa tttatcagcc gggcgatgct gcagcattac caagtcaagt 2843941 tacggccgtc taaacagcag aacggaatca agctgacact tgatcagcat gtggagcttc 2844001 ttgctgttcc tgacgaacta aagggagcgg cttacaaaac ctgtgttctc tatttccttg 2844061 atcacaacac aacaattata ggcatacaaa aaaaggaggg gccgatgctt tcccctcctc 2844121 ttacatacaa ggtgctcgaa acagatcaat tccttgccat ctagtgtaac agaacatcct 2844181 ccaattcttt cacgagagag gcgccgatat ccaaaaatgc cggatcaatt tccgcgtccc 2844241 gcctttccgg ttcggaaaat tgattaaaca gtgattggaa aggccctccc tcggcgtgat 2844301 cgtcaacatc cgcctgaaac acctgtctca gcataaatgg cgttccgatc cggacggccg 2844361 cccctcgttc atcgagactg ccctgtaccg cattgacggg aattcttaaa aataaatagc 2844421 cgtctctatc atcaatttta taatcaaagt agccatgatc gtattcccag ccgccgttta 2844481 tcacataacc gagcggcttc atcacttgtt ccagttcttg aagcagaaaa gactgcccat 2844541 ctatcgcgga aggtattggt atcatcagaa tgcccctttt ttcacttatc ctgtcccgcc 2844601 gaacaagact tcattcagag gcgcctacat ggaaatcgtt gtttctttcg cgcggccaac 2844661 aggaaagaaa gcgcattcaa ttaagaagta aacagccatt gccgctgcaa gccatacagc 2844721 tgaatcccaa gacacataaa caaccgttgc atagagtcct aatttagtga aaagagtatg 2844781 ggttcgtttt aaatgcaaaa tccgatgtac cgcatcggta aaaagggcaa gcggcaaacc 2844841 aatgagaaga aaggagtgga tgaaaaaatg tgacagcgtg ccgccaaagc ttgaagaaaa 2844901 ccctgtatac acggcatcaa aggagataag gaaacttaaa atagctgcag aaaaaccggc 2844961 aatgatgaga tgtttaacca attgtttcat gaacatcagc acctttctga ttttataaaa 2845021 agccgaccgg caaatgccag tcagctttct cacattaatc ttccagacgt ttttcaagct 2845081 ctgctttttt ctcttcaaag ccaggtttgc cgagtaacgc aaacatattg actttatacg 2845141 cttctacacc aggctggtca aacggattga cgccaaggag gtaaccgctc atcgcgcagg 2845201 ctttttcgaa gaaatataca aggtatccaa aagtatatgc attcagctca ggaatgttaa 2845261 cgattaagtt cggaacattt ccgtctgtat gggcaagcat tgtaccttgg aatgcttttt 2845321 tgttaacgaa atcaacagtt ttaccggcta aatagttcaa gccgtcaaga tcgttatccg 2845381 cttcctcaat tgtcagttca tgtttaggct tctctacgtt caggaccgtt tcgaataaat 2845441 ctctgcggcc ttcttgtaca tactggccta aagaatgaag gtctgttgaa tagttcgctg 2845501 aagaaggata aatgcccttc tcatctttcc cttcgctttc tccgaacagc tgcttccacc 2845561 attccgcaaa gtattgaagc gccggttcgt agttgatgag catttcaatt gttttgccct 2845621 tattataaag gacattgcga acaaccgcat attggtatgc tgggttatct tccagttcag 2845681 atgttgcaaa atctttgctc gcatccaggg cgcctttcat catgtcgtca atgttgacgc 2845741 cgctgacagc aatcggcaag agacctacag ctgttaaaac tgaataacgg ccgccgacat 2845801 cgtcaggaat tacgaatgat tcaaagcctt cttcgttaga aagcgttttt aatgcgccgc 2845861 gctctttatc agttgttgca taaatccgcg ctttcgcttc ttctttaccg tatttctctt 2845921 caagaagctt gcggaaaata cggaaagcga ttgcaggttc agttgtcgta cctgatttag 2845981 aaatcacatt aatagagaag tcaacatctt caagaagatc catgacgtct ctcatataag 2846041 atgaactgat gttgttcccg ataaaaatga cttgcggatt gccgcgtttt gcttttggca 2846101 aagtgttata aaacgcgtga ttcagcgctt caatcgctgc ccgcgctcca agataagaac 2846161 cgccgatgcc gacaacaagc aagacatcag agtcagattt gattttttcc gcgctttttt 2846221 tgatgcgcgc gaattcttct ttatcataat gttcagggag gtccacccag cctagaaaat 2846281 cgctgcccgc gcctgttttc tcatggatat tatggtgtgc tgtttttaca aagtcccgca 2846341 ggtatgtaag ttcatgttcg ttgaagaaag tcaacgcttt tgagtagtca aagcgtacat 2846401 gcgtcattgc ttgtccctcc ataacggtat aatgttttca tctttcactt tatatgaact 2846461 tatctgtgaa atcaagtcaa gaagaaaggg cggaatgact ggattccgcc ctttgggttt 2846521 atagagacgc gcgaaggatg gcaagcacgt catctttgtt cagtttttgg aagttgccga 2846581 agccgccgtg ttccatttcc ttggctgcga tatcagcaat cagctcaagc ttttcttctc 2846641 caatattgta atcagcaaga cgagaaggtg caccgaggct tgtccagaac gcagacagtt 2846701 tatcgattcc ttcaagcgca atttctttat ctgttttgcc ttcagtatca atgtcaaaca 2846761 tgttgagcat aaggttttta aaacggccta catttgtatc aagcgtgtat ctcatccaat 2846821 ttgggaacag tattgccaaa ccgcccgcgt gcggaatatc atatacagct gaaacagcgt 2846881 gttccattgt atgagaagcc cagtcaccga agtatcccat ttggagcgtg ccgtttaaag 2846941 caatagtacc agcatacaaa atcgtttcac gaagttcgta gttttccaga tcttcaagaa 2847001 gcttaggagc tgtttcgatg accgtctgca aaacagcaaa gcacattcta tcctgaagcg 2847061 gcgtgttttc aacattatgg aagtattgtt cgaatacgtg gctcatcatg tcaaccatgc 2847121 cgtatactgt ttgattttct ggaacggtga acgtattttc agggtctaaa atagagaaac 2847181 gcggatgagt gacattgctg ccccatacaa atttctcgtt tgtttcccag tttgtaatca 2847241 cggaatcagg gttcatttca gaccctgttg cagcaagagt taaaacagtg ccaaacggca 2847301 gcgcatcctc cgctgttact tttttgctga aaatatccca agcgtcaccg tcatatttga 2847361 cgccagctgc gattgccttt gtacagtcaa tcacactgcc tccgccgaca gcaagcagaa 2847421 aatcaatgtc atgctctctg caaagtccta tgcctttttc cactgtcgca agacgcgggt 2847481 ttggctctac acctgacagc tcatgaacaa cagcgccctc ttcttttaaa atgcctgtga 2847541 cttgatcata aaggccgttg cgtttaatgc tgccgccccc gtaaacaagc agtacattct 2847601 tgccgtatcg tttgaattct tttcttaatt gttcaagctg accttttcca aaaatcagct 2847661 ttgtcggatt ataataagtg aaattttcca tagtaaaacc tccaaatgat gctggtaaaa 2847721 aacagatttt ccattgtaac ataagttgac aaaaaagaaa aagggaagca gccaaacggc 2847781 tatttcccct ttttttatag tgatgctttc aaaattgaca gcacatcttc tttgttgagt 2847841 gatttaaatt ggccgaatgt accgttagcc attgccttgt cagcgattgt gtcaagctgc 2847901 tcatcattaa tatcataatc agcaagacgg ttcggagcgc caagacttgt ccagaatgcg 2847961 gacagcttat cgataccttc aagggcaatt tcttcatccg ttttacctgc ttcttcaaca 2848021 tcaaacacgc gaactgcaag ctgtttcatg cgggcagggt tttcagacaa tgtgtgtctc 2848081 atccaattcg ggaacagaat cgccagtccg ccggcatgcg gaatatcata aacggctgat 2848141 actgcatgtt caatattatg agtagcccaa tcccctcttg cccccataga aagcatgccg 2848201 tttaatgcga ttgttcctgt gtacaggatc gtctcacgca attcgtaatt ttcgagatca 2848261 ttgatcagct taggcgctgt ttcaatgact gtacgcaaaa gtgattcaca catgcggtcc 2848321 tgatacggcg tgtttgatac atgatggaag tattgttcga atacgtggct catcatgtca 2848381 accatcccgt agatcgtgtg gtttttaggt acggtgaatg tattcaccgg atcaagaatc 2848441 gagaatttag ggaatacgag cgggctgccc cagccgtatt tttcttttgt ttcccagttt 2848501 gtaataacag atcctgagtt catttctgaa ccagttgcag cgagagtcaa taccgttccg 2848561 aatggcaaag catcttttgg ctgatgcttt ttcgtaacga tatcccacgc atcaccatca 2848621 tacttcgctc ctgcggcaat cgcttttgta cagtcgatta cgcttccgcc tccgacagcc 2848681 agcaagaaat caatgttttg ttctttacag atggcaacac ctttattaac agtcgacaca 2848741 cgaggattcg gttccacacc tgctaattca tgcacggtcg ctccggcttt attcagctgt 2848801 tcaatcactt gatcatacag gccgctgcgt ttaatgctgc cgcctccgta cacaagcaat 2848861 acgttttttc cgtaaggttt gagttcctcc ggaagtcttt ccacttcgcc gcgcccgaaa 2848921 attaatttgg tcggattcca gtatgtaaag ttttgcatga catctcctcc ttagattttt 2848981 tattatgcag aatgtcctca ccacatgtaa agcaatcagc tctcaccgat cagcatacca 2849041 gatggtttta ttttgcaagg tgctgggaaa gaagctgata taagcgaggg caggccagct 2849101 tccctcatat ggagaatgca tgtatagatt ctccaatatg tcacaatcta taactgtttt 2849161 aataattcat ggaggaggtt gcaaaacatg agtaccattc aaagaatttg tcttgtatta 2849221 accatcattg gcgccattaa ctggggactg atcggatttt tccaatttga cttagtagcg 2849281 gctatcttcg gcggccaagg gtcagctctt tcccgaatca tttacggact tgtcggaatc 2849341 gccggcttaa tcaacctcgg tctgctattt aagccaaacg aggaaagatc acgtgaagaa 2849401 gcagcaaatc ctgaaatgcg ataggatatc aatcacgctg aaataggatt ttgcatgaaa 2849461 tcaaaagcac cgaacattcc tgtccggtgc ttttttcatg cttatttttt gataaggtct 2849521 ttgcggttgg acatttcgat ccactcttca agcttatctt ttaatgtgtt gaaaccttgt 2849581 ggtgtagaag cttcttcgct tacttgagca gctttaggtt ttcttggttt gctttctttt 2849641 ttctcaggcg cagcttgtgt cgcacgaatt gaaaggctga ttttgccttt ttcttcatca 2849701 acagcaagta cttttacttg tacttcgtcg ccaactgaaa ggtgctcgtt gatatctttt 2849761 acgaaaccgt gagtcacttc agaaatgtgt actaaacctt gagtttcttc atctaatgca 2849821 acaaacgcac catacgcttg taatcctgta actttaccag tgtaaacact gcccacttca 2849881 aattttgctg ccattcataa caactcctaa gttaaattaa atatctgttt atacgcaatt 2849941 taaaattata tcacacatgt cttatttccg caaagaaaac ttttttataa aaaatcaggt 2850001 ttatgcacag caaaaagggg gtaaactgaa aataccaaag gctttctagt attcccccct 2850061 tttattggat gcgaacaaaa ggttcgtatc tttttttatg ttgttttgtg caggaagcgt 2850121 ttcattctga ctaacgcttc ttgaagctgt tcaatcgagg ttgcgtatga acaacggata 2850181 tatccctcac cgctcggacc aaacacactt ccaggaacaa ctgccacttt ttcctgcgtc 2850241 agtagctcct cggcaaactg ttctgaactc attcccatgc ttttgataga tggaaaagca 2850301 tagaaagcgc cgcccggatg atgacagctg agaccgattt cattgagcga ttctacaaac 2850361 agattccgtc ttcttcgata gctttttttc attttttcta cgtcttccat gccgttcttc 2850421 aggccttcaa gggcggcaaa ctgcgccatt gcgggcgcgc acatcatcgc atactgatga 2850481 attttaagca tggcatcccg aagcaaggat ggtgccgcgg caaaaccgag cctccagccc 2850541 gtcattgcaa atgcttttga aaagcctgag atgactaccg tccgttcctt cattcccggt 2850601 aatgccgcta tacttgtaaa ttcctcatca tatgtcagct ccgcgtagat ctcgtcggct 2850661 aagacgatga catcatgttt tttggcaaac tcagcaatct cattcagctc ttccttcgaa 2850721 taaaccgaac ctgtcggatt cgatggtgag cagatgagaa tggcctttgt tttttcagtg 2850781 actgccgctt caaaatcagc agccgttgct ttaaatcctt tgtctgccgt tgtatgaacg 2850841 tgaaccggga taccgcctgc caaagaaaca agcgcatcgt acgcaacaaa acacggctca 2850901 ggaatgatga cttcctcacc tggattcaca atggcgcgga tcgcaatatc caaagcctga 2850961 cttgccccca ctgtcacaat cagctcatta tctggcgagt agctaaggtc aaacctgttg 2851021 ctcaaataac ggctgatttc ctcccgcaat gagtataaac ccgcattggc cgtgtatgac 2851081 gtatatcctt gttcaagaga gagaatgctt gcttcgcgga cattccatgc ggtaacaaaa 2851141 tcaggctcgc cgacgcctaa agaaatgacg ccttccatcg ttgccgccaa atcaaagaat 2851201 ttgcggatgc cggatggttt tatttgttgt acatagtctg ataaatacga agtcatttac 2851261 ggtgacacca cgattctttt gtcgtcgtct cctgtttcaa acactttgcc gtcatgcttg 2851321 tattttttca ggataaaatg ggttgtcgta gatacaactg aatcaagcgt tgagagttta 2851381 tccgaaacaa aacgcgctac gtcagacatc gaattgccgc gaatcacgac agacaaatcg 2851441 tatacgcctg acatcaggta aactgattca acctcttgga atcggtaaat ccgttccgcc 2851501 acttcatcaa aaccgacgcc ccgcttcggc gttactttga cgtcaatcat ggccgtaacg 2851561 ccctcatgtc cgtcgacttt tcgccagtca atcatagcgg aataatcgat aataaccttt 2851621 tctttctcca gtttgtcaat aattgttttc acttcattta cagggatgcc cgccatcttt 2851681 gcgattgttt ctaaatcggc gcggctgttt tcgtctaaaa tttctaatat ttctgtttct 2851741 ttttctgtca atttcatttg attcacacct ttgcaatgtc aagaaatctc atgacattat 2851801 atcacgtttt ttgacgaatg ctaagaaaaa acgaggagaa acttccgcta gaattgacaa 2851861 tttcagggca taatacaacc atcaaaaaaa gggagtgaca cagaatggag gcggtttcac 2851921 caataaggcg gtttacggtc gatggagtca atgtatacta cgaacattat caaaatcccg 2851981 gcaggcaaac gctggtctgc gtacacggtt ttttatcatc tgcattcagc ttcagaaaag 2852041 taattcctct ccttcgggac aagtacgaca tcatcgcgct tgatttgcct cctttcggcc 2852101 aatctgaaaa atcaagaacg tttatctata cctatcaaaa ccttgctaag cttgtcattg 2852161 ggattttgga gcacttgcaa gtgaaacagg ctgtgcttgt cgggcattct atgggcgggc 2852221 agatatcgct gtctgctgct ctccaaaaac ctgagctttt ttcaaaggtt gtgctgcttt 2852281 gcagttcagg gtatttaaaa cgttcacacc cgacgattat tttcgggacc catatcccgt 2852341 attttcatct ttacatcaaa cgctggctct cgaaagaagg cgtgatgaaa aatttattaa 2852401 atgtggtgca tgacaaatcg ctgattgatg aggagatgat tgacggctat ggcagaccgt 2852461 ttcaggacga gcagattttc aaagccatga caaggtttat ccgccacaga gaaggagatt 2852521 tagaacccga gcaattgaag aaaatgaaca agcctgctct attgatttgg ggcgaggagg 2852581 atcgaattgt cccaatggag atcggtaaac ggctgcacgc agatttgcct aattccgtgc 2852641 tgtactcact tggccagacc ggacatctgg tgcctgaaga acggcctgaa cttatttctg 2852701 aacacattgc tgattttatc aaataacaaa aaaaccggtg ctgaaccggt ttttttaagg 2852761 cgtgcaggag ctgctgtttt taatgaataa aagctggcca gccacttccc ggcagctggc 2852821 gatcggcagc gtttgttcaa aagaagtttc aaatatttgc tgaatgcttt tcgccagcaa 2852881 gtcgggatcg ttttcatcat agactgcctg cacgacatca acagcctccg tttcgtaaaa 2852941 ctcttctcca tatttaaacg ggtcccattt ggcaatgatc ttaatcattt ccctgaccgc 2853001 atgactttct tccatattca tcaccgctta taataaaatt tgcagttcta tcttatcata 2853061 gtgaagctta gaagaataaa catacatgag ggggtaacag aatgaacttt gataaacgag 2853121 aagaacgcct tggcacccaa tcggtcaaat gggataaaac aggcgaatta tttggcgtga 2853181 cagacgccct cccgatgtgg gtggcagata tggattttcg cgccccggaa gcgataactg 2853241 aagcgttaaa agagcgtctt gaccacggta tttttggtta tacaactcca gatcaaaaaa 2853301 cgaaggatgc tgtgtgcgga tggatgcaaa acaggcacgg ctggaaggta aatccggaaa 2853361 gcatcacatt cagccccggc gttgtaacag ctttgagcat ggcggtacaa gcttttacgg 2853421 agccgggcga tcaagtagtt gttcagcctc cagtttatac gcctttttac catatggtgg 2853481 agaaaaacgg ccggcacatt ttacataatc cgctgctaga aaaagacggc gcatatgcaa 2853541 tcgattttga agatttggag acaaagctta gtgacccaag cgttacattg tttattttat 2853601 gcaatcctca taacccttct gggcgttcat ggagccggga agatttactg aagctaggcg 2853661 aattgtgcct tgagcatggc gtcacagttg tatcggatga aatccattcc gatttaatgc 2853721 tgtacggaca taaacacacg ccgttcgctt cgctctctga cgatttcgct gatatttccg 2853781 tgacatgtgc tgctccaagc aaaacattta atatcgccgg attgcaggct tcagcgatca 2853841 ttattccgga tcgcctgaag cgcgccaagt tttccgcaag ccttcagcga aatggtttag 2853901 gcggactgaa cgcgtttgcc gtcactgcaa tcgaagccgc gtattcaaaa ggcggaccgt 2853961 ggcttgatga attgatcact tacattgaga aaaacatgaa cgaagcggaa gcctttttga 2854021 gcaccgagct gccaaaggtc aaaatgatga agccggatgc atcatacttg atttggctcg 2854081 acttcagcgc ttacggcttg tccgatgcag agcttcagca aagaatgcta aaaaaaggaa 2854141 aagttatttt agagcccggg acgaaatacg ggcctggcgg agaaggattt atgcgcctga 2854201 acgccggatg ctctcttgca accctgcagg acggcctgcg ccgcatcaaa gccgcattat 2854261 cgtaaatata gctgtaaacg cctttacgtc ttcatttgta aaggcgttct taataaagga 2854321 attttatatt ttacttctaa tatttagtgt tataatagat tcatatttta tacgaaagga 2854381 tttcacacga atggaaattc taaaagacta tcttctgcac atctgcttta ttttgtttcc 2854441 tattcttctt taccaagtgt tttggcttgg aaaacctgcg attcttgtgc caaaaataaa 2854501 cagcggtttg gtcacgctct tcgcctgcgg cgcctccgtt ttatgcatta ttttcccgat 2854561 tcatgaaatg gactacatac aatacggcct tcagatgatt cccgttatca tttgtttatt 2854621 ttacattagt accgcttccg gacttacagt cgccgcatct gtcctatgtt ttgaactgct 2854681 tttttacgaa ccttccgcaa tgtttgtttt cactttgctg ccttttctta tcattatccc 2854741 aatcttattt cagaaaaaat ggccattcat gtccaaagcg aaaaaactgc tgctgtcttt 2854801 attgatcagc tgcgtggaga ttttcctatt tttcgcctca agctggattc tttccgcctt 2854861 gaatatttta aattttcaaa aatcaggaat tttcgtttac gaggcggcag tctcagggct 2854921 tttccgctcc agtgttcttc tattaagcat ctatattatc gaaagcatcg ccgaaaatat 2854981 cgccctgcgt tcacagctta tccattctga aaaaatgacg attgtgagtg aactggcagc 2855041 gagcgtcgcc catgaggtca ggaatccgct gacagttgtc cgcgggtttg tccagctgct 2855101 ttttaatgac gaaaccctac aaaacaagtc gagtgcggat tacaaaaagc ttgtactgtc 2855161 agagcttgac cgggcgcaag gcattatcac aaactatctc gatatggcca aacagcaatt 2855221 atacgaaaaa gaggtttttg acctatctgc ccttatcaaa gagacaagct cccttatggt 2855281 gtcgtacgcc aattacaagt cagtaaccgt cgaggctgaa acagaaccgg accttttgat 2855341 atacggagac gcaacaaagc tgaagcaggc tgtcatcaac ctgatgaaaa acagtattga 2855401 agcggttcct cacgggaagg ggatgatcca catatcagcc aaaagaaacg gccatacgat 2855461 catgattaac atcacagaca atggggtcgg gatgacagac catcaaatgc aaaaactcgg 2855521 cgaaccttat tattccttaa aaacgaacgg aacgggactc ggcctcaccg taaccttttc 2855581 cattattgaa catcatcacg ggaccatttc atttaacagc agcttccaaa aaggcactac 2855641 ggtgaccatt aagcttcccg ctgatcttcc tcactagcaa atcgattgga actttaatag 2855701 aataaatgcg aggtgatgac agatgagcac gtttgagaca ggctctatcg ttaaaggatt 2855761 ttacaaaaca ggtgtataca taggagaaat cacggcttgc aggccgcagc attatttagt 2855821 gaaagtgaaa gcggttctta cccatcccgc tcagggagac cttcatcatc caaaacaggc 2855881 ggatgtgcca ttttttcatg agagaaaagc gctcgcatat ggtgaacaga ccaatatccc 2855941 ccaccatatg gtgaagcctt atgacggtga agtgccggat tataccgaat ctctgcggga 2856001 ggcgacagca cagatgagag ccaaattgaa tgaggatggt tcggagtggg caaagcgctc 2856061 ccttcataat ctggacattt tagaaaaaga atattttaac cggccataac ccagtctgac 2856121 aaaagattgg gttttttacg tcgcgcgctt caacagttcg gttaaatcga ttctctcgcc 2856181 gattgtgggc ggttttggct tttcgagata ctgcttatcc tgctcaacaa gcttaaaaag 2856241 tttatatgct gtgagagcat catcaagcgc tttatgatgg gtgccggttc cggaatctcc 2856301 atactcttcg gcagctttcc ataaacccgt caatgtccgg tctccaaaaa agtttttgta 2856361 ttcaagcgat aaatctctca tttctccctt aaacgggaaa gggatatggt taaacataca 2856421 gttttgcttc agcactttca tatccatgtt tccccacgta ataattgtgc tgtttttctc 2856481 aggatccagc tcgtttagtt tacggatgaa atcctcgaat ctcattcctt cgtctacctg 2856541 tttttgggtt atttttaaaa atgatttgca gcgtttcgta agcttcggga actttttcgg 2856601 tctaacatag ctagaaaacg tctcaaccac ttcatcatca atcgacttta caattccggc 2856661 ttcaatgatt tccgggaaga agttttgagg actgtacttt ccatcaggca ttgtaaattc 2856721 gaaatcaata atgagtaagc tgtttgtcgt caccttttac acctgccttt cctccgatca 2856781 gaaaatgcta tctttatagt atatcaattc cccttctcga catttcttca ttttctaaaa 2856841 ataatgaatt ttcccagccg cttcgtttct tttaaattgt gaatcgtttc tttataatta 2856901 gtaaggaacc cgaaataata agaaggtgat gttatttcta tccgtaagaa aaactttgtc 2856961 attgtgtggc tggcgaactt ttttgtctcc gctagcacaa cgatgatcgt tccttttctc 2857021 tccttataca ttgagacgct cagctctttt tcaaacggct ttgtgcaaag gtggagcggc 2857081 tatgtgttcg gcattacatt tctcatggcg tttttggtat ccccgttttg gggacggttc 2857141 ggagacaaac gcggatacaa gaaaatcctt atggcaaccg gaacaggcat tgccctcagc 2857201 attttcttca tgggctttgt tacatcggtg taccaattgt tttttctgcg tatggcaatg 2857261 ggtcttgtaa ccggattcat cccgacatct cttgcgatga tttcggcaca gactccgaag 2857321 agctcagctg gcaaaacact cggcacgctg caaatggggc aagtgtccgg aagcttgttc 2857381 ggcccgcttt tgggaggcat gcttgctgat cgtttcggct ttacgtatac cttttttatc 2857441 acatcctttg tgattttctc gtctgttctt ctcgtgttat ttggtgtcaa agaaaagcat 2857501 cttgcagaga aaacagccaa acgtacgtct tactcgagaa aagaagtgct ctcctatatt 2857561 tttcaccatc cggcgctgtg ggtcatgatg ctgttaacca tgctgattca aacaggcaat 2857621 ttcagtatcc agcccctgct cgctttatat gtaaatgagc tgcacggacc tgtcaatctt 2857681 gcctttttct ccggcatggc attttcagca acggggctcg gaagtttgct gctggctaga 2857741 aaatggggtg atctgggcga ccgctacggc caccgccgca ttttaatcgg acttttgctc 2857801 gccgcctctt tcttttttat tccgcaggcg ctcgcgtcct cactcagcgt gctccttgtt 2857861 ttcagatttt tattcggaat ggcgatgggc ggtttgctgc catgcattac ggcagcgatc 2857921 cgcgttcagg ctcccggcag cattcaaggt gaagttctcg gctacaatgt cagctttcgc 2857981 tttttaggaa acgtgctcgg gcctctgctc ggcggaatca tatcgagcca ttttaccatt 2858041 tcggccacct tttacgtcac ggcgtttctc tttttcgccg gcgcctgcat gctttggatc 2858101 atgcagaaac ttcggaaaga ttcttatgcc aaagcaagct gattccgaga aaaaactaag 2858161 gaatcttcta aatttaacct tctcgtaatc tcaaaagaat ggtacgatat ggctagaatt 2858221 taggagaaaa gagagtgacc atgttacgaa aaataatcgg atggattttg ctcctttgca 2858281 taatcccatt gtttgcattt acagttatcg cttccggaaa agaagtaaaa caaatgaagt 2858341 ccctggatca ggtgcttgat aaaaatattg atctgaaaga tatcagcctt gttcagaaca 2858401 gctacatgta tgacagggac ggctcccttg tctcggaaat cgtcagcgac cacgaaaacc 2858461 gtgtgctcgt tccatttaac aagattcccg aggaagtcaa acagattttc ttaacatctg 2858521 aggaccgcca tttttacgag cataaaggct ttgactttat gggaatggtg cgggctactg 2858581 cttctaacgt aaaagacaag aaaattgacc agggtgccag caccatcaca cagcagcttt 2858641 caagaaactt gtatttgagc cacgaacgct ccttcagccg caagctgaca gagctcgcgt 2858701 attcctatca gctggagaaa aaatatacga aaaatgaaat tcttgaagct tacttaaata 2858761 ccatttattt caacaacggt gtttacggcg tcggttcagc agctcaattc tatttcagca 2858821 aaccgctgaa atctctcaca gtgggagaaa tggcttttat ctgtgctata cctaataacc 2858881 ctacattata tgatcctctc aagcattttg actacacgaa aagccgtcaa gaacgtttac 2858941 ttaaagggct aaaagatgcc ggggtcatta cggacaaaga gctgaaaaaa gccgtaaaac 2859001 aaaaaatcaa actggatgtt gaaaaaagag aagacaaata tcctgactac gtttcctacg 2859061 tcaatgatga attcactcag ctggtgtctg aatcagaagg ctttgataaa cgccttcaaa 2859121 aagcatcagg aaaacaaaaa gaaaagatcg agaacgagct gtccgcaaga gtcagcacgc 2859181 tgatgaaaga cggagtgaaa atttatactg cacttgatcc gtacatgcaa aatcaagttg 2859241 tggcacaaat gaattccaag ctcccgtatg cggacgtaca gggcggagcg gctgtgatta 2859301 atcaccagac gcatcaaatc attgctctat ccggcgggaa aaactatcaa aaatatgact 2859361 ttaaccgcgc ctaccaggcg tacaggcagc cgggttcatc cattaagccg cttcttgatt 2859421 acggccctta tattgaacag accggcgcga caacaagcag caccattgat gccagcaagt 2859481 tttgcagcaa agactactgt ccgcaaaact acaataaccg cacttacggc acagtgacgc 2859541 ttgatacggc gtttaaaaat tcatataata ccccggctat tagaatgctc gaccgcgtcg 2859601 gcatccaaaa ggcattcagt tatattgagc cgtatcattt tgccaaactt gtcgacagtg 2859661 actatcttct tccggcggcg cttggcggat ttacaaacgg catgacgcct cttgagatga 2859721 caaaggctta tacgacattc ggaaacagcg gaagctatac gccgagccat gcgattacaa 2859781 aggtgacaga ccttaaagga aaaacacttt ataaatggaa tgataaagcg actcaaatat 2859841 tcagcgtccg cacgaacatg cagctgaaaa aactgatgtc ttccgttgtg aaaagcggaa 2859901 cagggaaaaa agcatatttc aatgcgcctt acatcggcgg taaaaccgga acatcaaatg 2859961 attatcacga tatgtggttt gtcggcctga ctgatacgta tacaatgggt gtctgggtcg 2860021 gaaaggatac accgaccagc gttgaatatc ttcacagcat cagccctcag ctttccatct 2860081 ggaaaggaac gctgcaagcg gcttattaaa ggatcggagg ggatatggag tgacttcaga 2860141 acaaattcca aatcgcgttt tgctgtttga cggtgtctgc aatttatgca atggcgccgt 2860201 gcagtttatc attaaacgtg atccggacgg attgatttct ttcacatcgc tgcagtcgga 2860261 aacaggacag agcctgctga aaaaaagcgg gcttccgact gatcggtttg acagctttgt 2860321 ctttattgaa gacggccaag tgtacacaaa gtcaactgca gccattaagg ttttcaggca 2860381 tctgcgaggc ccatggcggc tcttcgtcct ttttttcgca gtgccgaagc ctgtcagaga 2860441 tatggtctat tctttcattg ccaaaaaccg ctataagtgg tttggcaaaa aaaatgaatg 2860501 tatgctcccc tccccttcca ttaaaaaaag atttttaccg taaataaaaa atggctagga 2860561 agctagccat cacagattgt tgacaaaatc ctaaaacggc ttcgttttag gattttgtca 2860621 tctattcagc gtgattgaaa acttttgaag ttgtgaaacg gcggaaacct gagaatctag 2860681 ccgccgtttc attgcgtaca gagcacgaag cgcaaatctg accaccaaac gctgaaatgg 2860741 ctagcttaca caggtaagct agccattatg ctattataaa gcttgataaa tatgaacaga 2860801 ataccgataa caaaggtaaa ccaaaacagc agttccaata gaatgaatcc aactaatgac 2860861 atgagagaaa gcgtcgaata aatccggtat acggtaaaca caaagtaagc gagcgtgacg 2860921 accgcaaacc agatcacaat ccaaatgaca ttttgcaaga gcacaaagga taaaatcccg 2860981 ccgcccaaat aaatcatgga acccattctg agttttttca ggttgttccc ttccggatca 2861041 ttagcaaaaa acagcaatga cagctcggtc acggtatttg caattaattt cagagcggac 2861101 agaaccataa aatataaaag tgcaaaggca gcaaataacg caagcctgat tcctttctct 2861161 gaaaaataat cgagcattcc atcatacatt ccaaatgaag acagcatctt caacgcataa 2861221 agtgaagttg agatggataa ggacgaacta aaaagcagga tcgcaatcag cggaaaatat 2861281 cctgtcaaat aagtattttt catataaaaa agtccctttc tataatctac ctcatttatt 2861341 atggaggact taaaacacat tgacaagata aattattcca ttttttctcc tttttacgaa 2861401 ttacgggccc aaatcttcac aaagcagcat tttgagagta aagtagtacg caggaatcat 2861461 aaaacgtaag gaagttttat atgaaaaaaa cattaaaact gcaaaccaga ctcaccatat 2861521 ttgtttgtat cgttgtatta atcgcattgc tcattacgtt ttttacagtc ggtgcccaaa 2861581 ccaccaaacg aattagagat caggaaaagg ccactgcgct gcagactgct gaaatggtag 2861641 ctgaagcgcc gatgacagcc gctgctttag aaagcggaaa aaaacaaaag gaactgcaga 2861701 gctacacaaa gcgggttcag aaaattaccg gcacggaatt tgttgtcgtc atggatatga 2861761 acggtatccg caaaactcat cctgacccga gcaaaatcgg aaaaaaattc agaggcggtg 2861821 atgagtccga ggtattaaaa gggcatgtcc atatcagcac agcctctggc acgctcggga 2861881 aatcgcagag agcgttcgtc cctgtctacg cggagaatgg aaaacaggtc ggtgcagtcg 2861941 cggtcggcat caccgtaaat gaaattgatg aagtgatcag ccatagctta cggccgcttt 2862001 actttattat ttgcgtcagc atcttcgtcg gtgtgatcgg agccgttatc gtcgcccgta 2862061 cagtgaaaaa tatcatgtac ggacttgaac cttatgaaat tgcgactctg cttgaagaac 2862121 ggagcgcgat gctggaatcg acgaaggaag gaatactcgc tgtcgatgaa catggcaaaa 2862181 ttaaacttgc caacgcggaa gcaaaacgcc tattcgtcaa aatgggcatc aacacaaatc 2862241 ccattgatca ggatgtagat gacatcttgc cgaaaagccg cttgaaaaag gtcattgaga 2862301 caaaaaaacc tcttcaagac agagacgtcc gcattaacgg gctggagctt gtgtttaatg 2862361 aagttcctat ccagctgaaa ggacaaactg tcggagcgat tgcaacattc cgcgacaaga 2862421 ccgaggtaaa acatttagct gaacagcttt ccggtgttaa aatgtatgca aacgcactga 2862481 gagcgcagtc tcatgaattt atgaacaaac tgcatgtgat attaggtctc gtccagctga 2862541 aagagtatga tgatcttgga gattatatta aagatatagc catacagcaa aaatcagaaa 2862601 caagtgaaat tataaatgat gtcaaaagct ccgtactggc cggttttctg cttggaaagc 2862661 aaagctttat acgtgagcag ggcgcaaatc ttgatattga atgcaacggt gtcatcccga 2862721 acgcggcaga cccttctgtc atccatgaac ttattacaat catcggaaat ctcatcaaca 2862781 atggcttaga tgccgttgcc gatatgccga aaaaacaaat caccatgtcc atgcgcttcc 2862841 ataacagcat acttgatatt gaaattaccg atactggagc aggcatgtct gaagaagacc 2862901 aagccaaagt atttgaacaa ggctattcaa caaagggcaa aaaccgggga ttcggccttt 2862961 atttcacaca gcaaagcatc gaaaatttaa aaggccaaat gatcctcaca agcgaaaaga 2863021 atgaaggaac gacattcagt attcgcatcc cgtacgaacc gaaggaggaa aatcatgatt 2863081 aatgtactaa tagttgaaga tgaccccatg gtgggtgaat taaataaacg atacttaagc 2863141 caaatagatg gctttcagct gaaaggcatc gcttcttcct ttcaaagcgc tctgcatatt 2863201 ttaggggagc accatattga cctcattttg cttgatattt atatgccggg aaaaaacggg 2863261 ctggaactgc tgacggaatt gagagcccaa aatgaagcgg ttgacgtgat tgtcatctca 2863321 gcggccagcg agcttgacgt gatcaagaaa acacttcggt acggagctgt tgattattta 2863381 atcaaaccgt ttgaatttga acgattccaa acggctctgt ctgattacag acgaaaacaa 2863441 aaggtgtatt caacccatcg caacatgagc caaaaagaac tggacgccga gctttttcaa 2863501 aagaaagaag caacagaaaa agtgcagctt cctaaaggcc tgacaaaaag cacgctgaag 2863561 ctgatctggt ccagtatcca gtcatttgaa aatgaatctt ttacgacaga agacttggca 2863621 aagcacacag aaatctctca agtatccata cgaaaatact taaagtttct tgaagatata 2863681 caggttctga atgtagaaat ggcgtacgga acgatcggaa gacctgtgtt tcagtacaac 2863741 gtcaacaaca gtaacattaa cggaataaag caatatctat aagaaaacgc actgcttgct 2863801 ttgagcagtg cgtttttctg tcatatctct tgccaagatg cttgattcta ttgttgataa 2863861 gttatacaag aataacaaag ggctttcaca tttttaagca aataattcta aaaatagata 2863921 atttttaaaa aattatgcga aattctattt atttcttatt agttaaatga taaattatga 2863981 ttggttagtt gatcccgaaa aactaagtca taagtcttac ttcagaaaac gatgtcacgg 2864041 ttttccgccc ggaacgcctt ccgcatcctt ctcttccccg cctttcgaag gaaatactca 2864101 caccacgctt attcagggaa gaatagaact gtctcagcgc attccatttg ttattatcag 2864161 aaaattttat cgattctaag aaattgttca ggacagccca tcacatgact ggccggatca 2864221 gctttgaacc aaatttttct ggggggttat atcttgaata aacgaaaaat cggattggcg 2864281 atgtcacttg tgatcgcagc aggcaccata ttaggagcat gcggaaacag cgaaaaaagc 2864341 agcggctcag gcgaaggcaa aaacaaattc agtgtggcga tggttactga cgtaggcgga 2864401 gtggatgaca aatccttcaa ccaatcagcc tgggaaggca tccaagcctt tgggaaagag 2864461 aatgggctga aaaaaggcaa aaacggttac gactatcttc aatccaaatc tgatgcagac 2864521 tatacaacga acttaaataa attggcgcgt gagaattttg acttaattta cggcgtcggc 2864581 tacttaatgg aggattcaat cagcgaaatt gctgaccagc gtaaaaatac aaactttgcg 2864641 attatagatg ctgttgtcga taaagacaac gtcgcaagta ttacgtttaa agagcaggaa 2864701 ggctcatttc tcgtcggagt ggccgcagcc ctatcaagca aatcaggaaa aatcggcttt 2864761 gtaggcggca tggaatcaga gttgatcaaa aaattcgagg tcggcttccg tgccggcgtg 2864821 caagcagtta accctaaagc cgttgtagaa gtgaaatacg cagggggttt cgataaagcc 2864881 gatgtcggta aagcaaccgc cgaaagcatg tataaatcag gcgtagatgt tatttatcac 2864941 tctgcgggcg ccactggcac aggcgtcttt actgaagcga aaaacctgaa aaaagaagat 2865001 ccaaaacgcg atgtctgggt catcggtgtc gataaagacc aatacgcaga aggccaggta 2865061 gaaggaacag atgataacgt caccctcact tccatggtga aaaaagtaga tacagtcgtt 2865121 gaagatgtaa cgaaaaaagc gagtgacgga aagttcccgg gcggcgaaac acttacctac 2865181 gggcttgatc aagacggagt cggcatttct ccatctaaac aaaatctatc ggatgatgtg 2865241 atcaaagcgg tcgataaatg gaagaaaaaa atcatcgacg gattggaaat cccggcaact 2865301 gagaaagagc tgaaaacctt caaagctgaa taagaatcgc agggataagg aggtcgagcc 2865361 cttatccctt gtttttcttt tattttgaaa taaaggagcg gtcaatcaat ggaatatgtc 2865421 attgaaatgc tcaatatccg caaggcgttt ccaggtatcg tcgccaatga caatatcaat 2865481 cttcaagtca aaaaaggcga aatacacgcg ttgctcggtg aaaacggagc ggggaaatca 2865541 acattgatga atgtcctttt cgggctgtat cagccggagc ggggtgaaat tcgggtgcgc 2865601 ggcgagaagg tgcacatcaa cagcccgaac aaagcgaatg accttggaat tggaatggtg 2865661 caccagcact ttatgcttgt tgacaccttt acagttgctg aaaatattat tctcgggaag 2865721 gagccaaaga agtttggcag aattgaccgg aagcgtgctg gccaagaggt gcaggacatt 2865781 tccgatcgat acggcctgca gatccatcct gaagcaaaag cagctgacat atcagtcggt 2865841 atgcagcagc gcgcagaaat attaaaaacc ctctaccgcg gtgccgacat tctgattttt 2865901 gatgaaccga cggctgtttt gacgcctcat gaaattaagg aactgatgca aattatgaag 2865961 aacctggtca aagaagggaa gtccatcatc ttaatcaccc ataagctgaa agagattatg 2866021 gagatttgtg accgcgttac ggttatccgt aaaggaaaag gcatcaaaac ccttgatgtc 2866081 cgtgatacaa accaagacga actcgccagt ctaatggtcg gccgtgaggt atcgttcaaa 2866141 actgaaaaga gagctgctca gccgggagcg gaagtgcttg cgattgacgg cataactgta 2866201 aaggataccc gcggaataga gacagtcaga gatttgtctc tttctgtcaa agcgggagaa 2866261 atagtcggca tagcaggcgt cgacggaaac gggcaatctg agctgatcga agcggtgaca 2866321 ggactccgca aaacagattc aggaacaatc accttaaacg gaaaacagat ccaaaacctg 2866381 acgccaagaa aaatcactga atccgggatc gggcatattc ctcaggatcg ccataaacac 2866441 ggtctcgtcc ttgattttcc aatcggagag aatatcctgc tgcaaagcta ttacaaaaag 2866501 ccgtattcag cattgggcgt tttacataaa ggcgaaatgt acaaaaaagc acgcagcctg 2866561 atcactgagt acgatgtcag aacgccggat gaatatacac acgctcgggc attgtcaggc 2866621 ggaaaccagc aaaaagcgat tatcgggcgg gaaatagacc gaaatcctga tttattaatt 2866681 gccgcccagc cgactcgcgg ccttgatgtc ggagcgattg aatttgtcca taaaaagctc 2866741 attgagcagc gtgatgccgg gaaagccgtt cttctcctct cgtttgagct tgaagaaatt 2866801 atgaatctca gtgacagaat cgccgttatt tttgaaggac gcattatcgc cagcgttaat 2866861 ccgcaggaaa ccactgaaca ggagcttggt ctcttgatgg caggaagcac gcaaaaggaa 2866921 gcggggaaag caaatggtta aacgactctc tcatttactc gtgccgctca tcgcaatcat 2866981 acttggtctt gcggccggcg cgttgattat gcttgtgagc ggctacagtg tggctagcgg 2867041 atattcggct ttgtggaatg ggatattcgg agaaatctat tatgtcggag aaacaatccg 2867101 gcaaattacg ccttatattt tatccggatt ggctgtcgcc tttgcattcc gaaccggact 2867161 ctttaatatc ggcgtcgagg gacagctgct cgtcggctgg acagcagcgg tttgggtcgg 2867221 tacggcgttt gacggaccgg catatattca cttgccgctc gcattgatta cagcggcagc 2867281 tgcaggagga ttatgggggt ttattcccgg cattttgaaa gcgcgatttt acgttcatga 2867341 agtcattgtc accattatga tgaattatat cgcgctgcac atgaccaatt acatcatttc 2867401 aaacgtcttg acagatcatc aggacaagac ggggaaaatt cacgaatccg cctccctccg 2867461 ctctcctttt cttgaacaga tcaccgatta ctcacggctg catttgggaa tcatcgttgc 2867521 ccttctcgca gcagttatca tgtggtttat catcaacaaa tctacaaaag gatttgagct 2867581 ccgggcggtc gggtttaacc agcacgcttc ccagtatgcc ggcatgagcg tgcggaagaa 2867641 tatcatgacc tccatgctta tctccggcgc ttttgcaggt cttgccggag ccatggaggg 2867701 cctagggaca ttcgaatacg cagcagtgaa aggcgcattt accggcgtag gctttgacgg 2867761 tatcgctgtc gctcttctcg ggggaaacac agccgtaggc gttgtactgg cagcatgcct 2867821 gcttggcggg ctgaaaatcg gcgcattaaa tatgccgatt gaatcaggcg ttccatcaga 2867881 ggtcgttgat attgtgattg ccattattat tctatttgtg gcttcaagct atgcgattcg 2867941 tttcgtcatg ggcaaattga agaaaaaggg ggcgaactaa gtggacattg tgcagatttt 2868001 atctatcatt gtccctgcca cactcgtcta tgcggccccg cttattttaa ctgctctcgg 2868061 cggcgtgttt tccgagagat caggtgtggt gaatatcggc ctagaaggcc tcatgattat 2868121 cggggcgttc accagcgtgt tatttaattt attttttggt caggaattag gtgccgccgc 2868181 accttggctt tcgctccttg ccgccatggc agcaggcgcc ctgttttcac tgattcacgc 2868241 ggcagcggcg atttcgtttc gcgccgacca gacagtcagc ggtgtcgcca ttaacatgct 2868301 ggcgcttggg gcaactttat ttatcgtcaa actgatctac ggcaaagcgc agacagacaa 2868361 aattccagag cctttttata agacgaaaat ccccggtttg ggcgatattc ccgtcttggg 2868421 aaagatcttc ttttcggatg tctattatac gtctattctt gcaatagcac ttgcctttat 2868481 ttcctggttt atcttgttca aaacgccgtt cggccttcgt atccgttctg tcggcgagca 2868541 tccgatggcg gccgatacga tgggaatcaa cgtatataaa atgcgctaca tcggcgtgat 2868601 gatcagcgga ttgttcggcg gtctcggcgg cggcgtatat gcctccacaa ttgcgcttga 2868661 tttcacgcac tctaccatct ccgggcaagg ttttatcgcc ctggcagcgc ttgtattcgg 2868721 aaaatggcat ccgatcggag cactgggggc cgccctgttt ttcggattcg cccaaagctt 2868781 aagcatcatt ggatcgctgc tccctctttt taaagacata ccaaatgtgt atatgctgat 2868841 ggctccttat atcttaacga ttctcgcttt aaccggcttt atcgggcggg cagatgcgcc 2868901 aaaagccaat ggcgtgcctt atattaaagg aaaaagataa acattctccc ctgggaagac 2868961 gattctcagg gatttttttc taatccaaaa gaccccctta atttaattgt ttattagttt 2869021 tttaacttaa aaaaatatga agtgttaacg ctttcttgta gactgtaaca aacaatacat 2869081 gggggtgtat gacatgggag caattccaaa aacggggaca atttcacctg agcaaaaaga 2869141 ctcacaggag aaaaacctgt ttcaaaaaat ttggtcttgg gaaatcggtg tgattccttt 2869201 gccattatac acagtattag ctgttattat tattcttgca gcatattaca atgagctgcc 2869261 ggcaaatatg cttggcgggt ttgccatcat tatgattctt ggtgtgtttc tcggagacat 2869321 aggccaacgc ataccgatat tgaaggatat tggcggccct gctattttat ctttgtttgt 2869381 tccttcattt ttagtctttt acaatgtact gaattcaaca tctttagacg ctgtaaccaa 2869441 cttgatgaaa acgtctaact tcctttattt ctatatcgct tgccttgttg tgggaagtat 2869501 cctcggtatg aacagaattg ttttaataca ggggtttatc agaatgttcg ttccactggt 2869561 tgcaggaacg atcgcggccg ttgcagccgg catccttgtc ggatttattt ttggctatag 2869621 tgcctatgat tcctttttct ttgttgttgt cccgattatt gccgggggaa taggtgaagg 2869681 gattttgccg ctttcaatcg cctattcaca aatactgggc tcatccgccg atgtatttgt 2869741 gtctcagctg gtgccagccg caattatagg aaacgttttt gctatcatat gtgcagcctt 2869801 aatgaaaaag cttggcgaca agcgtccaga tctaaatggg aacggacgtc tcgtaaaatc 2869861 taaaaaagca aatgagattt tcaatcaaaa agaagccgaa gcaaaaattg attttaaact 2869921 aatgggagca ggagttctgc tcgcgtgtac attctttatt tttggcgggt tattggagaa 2869981 attcatcttc atcccgggcg cgatcttaat gattatttca gctgcggctg tcaagtatgc 2870041 aaatattctt ccgaaaaaaa tggaagaagg cgcttaccag ctttataagt ttatttcttc 2870101 aagctttaca tggccgctga tggtcggtct cggcatcctc tttattccgt tggatgacgt 2870161 agcgtctgtg atttctatac cgtttgtcat catctgtatt tcagttgtta tcgcgatgat 2870221 tggttctgga tatttcgtag gcaagctgat gaacatgtat ccggttgaat ccgcaatcgt 2870281 tacctgctgc cacagcggtc tcggcggaac gggtgatgtt gccattttat cggcatcagg 2870341 aagaatgggc cttatgccgt ttgcccaaat ttcaacccgt ctcggcggtg caggcacagt 2870401 tatttgcgcg acagtgctgc ttcgtttttt cacttcataa acagaaagag ttccgtttta 2870461 tgcggaactc tttttttatt tattcacaat ccgaatatac tctcggggac caaacggcag 2870521 atcctttgat tccgtctcac tcattctggc tgacaggtgg tgctccagta aatacagctc 2870581 ccactcatca caagccgcca caccgctgcg cccgtcatat tgattcaaca tgaatgcccc 2870641 tgcaaatact gagcagaata aacctgagca catcacgact tttgttttca catgaccagc 2870701 tcctttcctt cagcttgatc aggattgatt ttaaatatac aaataacctc ttttttgtta 2870761 gacttatttt gaggtcaaaa gaactcataa aaatccatta cagcagttcg aagcgtggca 2870821 gcttgcagaa aagtgcgata taatttggac taggtcgttt gaccgtatat tttatacata 2870881 gcgcattttt caattgagaa cgagaaaagg aggtcttatc tttgcagctc ttacatcttg 2870941 ctattttatc gcctttttta tttgctttta tcattccctt cttggcaaaa tacgcaaaaa 2871001 gagtgcatac gggctggttt gtgttgatcc tgcccgtctt gctgtttata tactttctcc 2871061 caatgatcag gatgacgcaa tctggagaaa cacttcgatc ggtattagag tggattccgt 2871121 cactcggcat taactttacc gtttatatag acggcctcgg gttattattc gctttactga 2871181 tcacaggcat tggctctttg gtcactcttt acagcatttt ttatttatcg aaagaaaaag 2871241 aacagcttgg gcccttttat gtctacttat tgatgttcat gggcgccatg ctcggcgtcg 2871301 ttctagtaga caatgtcatg gttctctaca tgttctggga gcttacaagc ctttcatcct 2871361 ttttgctgat cggctattgg tataagcggg aaaagtcgcg ctatggcgca gccaaatcac 2871421 ttttgattac ggtcagcggc gggctgtgca tgctcggcgg atttattctc ctttatttga 2871481 taacggattc cttcagtatt cgagagatgg ttcaccaggt tcaattaatt gccggccacg 2871541 aattgtttat cccggctatg attctcattt tattaggggc ttttacgaaa tcggcgcaat 2871601 ttccttttta catctggctc cctgacgcga tggaagctcc gacgcctgtc agcgcttatc 2871661 tccattcagc tactatggta aaagccggca tttatgtgat tgcgagattc agtcctattt 2871721 tcgccttttc agctcagtgg ttttggatcg tgtccctcgt cggcctcttt acgatggttt 2871781 ggggttcatt ccatgccgtg aaacaaactg atttaaaatc gattttggcg ttttcaaccg 2871841 tcagccagct cggcatgatc atctccatgc tcggagtcag tgctgcggcc cttcattacg 2871901 gacatacaga atattataca gttgccgcta tggctgccat tttccatttg atcaaccacg 2871961 caacctttaa aggaagcttg tttatggcag tcgggattat cgatcacgaa acaggcacac 2872021 gggatatccg gaagctaggc ggcctgatgg cgattatgcc gattactttt accatttcct 2872081 taatcgggac attttcaatg gccggcctac cgccgtttaa cggatttttg agtaaagaaa 2872141 tgtttttcac aagcatgctt cgcgtgacac attttgacct gttcaacgtg cagacatggg 2872201 gcgttctgtt ccctcttttc gcctggatcg gaagtgtatt tacgtttatc tacagcatga 2872261 aattgctgtt taaaacattc agaggaaatt accagcctga acagcttgaa aaacaggctc 2872321 acgaagcgcc tgtcggtatg ctcgttccac cggtcattct tgtcgctttg gctgtcagtc 2872381 tcttcttttt cccgaatata ttgtcgtaca gcctgataga gcctgcgatg aactcaatct 2872441 atccgacact gcttgacggc catgagaaat tccacgttca catttcacag tggcatgggg 2872501 ttacaacgga attgctcatg actgcgggta ttgttgtgat cggaacaatt ggttatttgt 2872561 cgctgaataa gtggaaagga atctataaac tgtttccttc gaaactcaca ctcaaccggt 2872621 tatacgataa gcttttgact atgatggaga aaggctctta ccgggtcaca aaacaatata 2872681 tgaccgggtt tttaagagat tatttgctgt atatcttcgc tggtttcatc attctgatag 2872741 gcggagcttt tgccattaaa ggcggatttt catttaaaac ggaaggcatg gctaaaatcg 2872801 gtgtatacga aatcattttg acgcttgtca tgatcagcgc cacagtggcg actgtttttg 2872861 ctaggtcaag actgacggcg atcattgcac tcggtgttgt cggttatacg cttgcattgt 2872921 tttttgtcat tttcagagcg ccggacttgg cattgactca gctcgtcatt gaaacgattt 2872981 ctgtggcact gtttctgctt tgcttctacc atttgccgaa actgaggctg aaaacaaaaa 2873041 cgagaacgtt ccggatgacg aattttatca tttctttagg cgtcggtgtt atcgttacac 2873101 tgctcggcat cgcatcctca agccagcgga caaaagacag cattgcgtcc ttctttgtca 2873161 aacacagcca cgatctcggc ggaggggata atgtcgtcaa tgtcattctc gttgatttca 2873221 ggggatttga tacaatgttt gaaattacgg tattaacgat agccgctctc ggcatttaca 2873281 gcatgattaa aacaaaagta aaagaggagg ggaaaagcgg tgaatgaaca aaaaacaaat 2873341 gacttgattc ttcaaaccgc gacaaagctt gtatccttta tcattttgct tttctctttc 2873401 tatttatttt tatcagggca taacgcgccc ggaggaggct ttgtcggcgg actgatcacg 2873461 tcctcttcca tcgttctctt gctcttggca tatgatttaa aaaccgtgcg ttcccttttg 2873521 cctgtcaatt tcatttatgt cgcgggagcc ggccttctgc tcgctgtatt aacaggcgtt 2873581 ggctcctttg tcttcggggc tcctttttta acccacacat tcggatactt tcagctgccg 2873641 atccttggga aaacggagct cgccacagcg acgatatttg atttaggcgt ttatcttgtt 2873701 gtcgtaggca taacgatgac cattattcaa acgattggag aggaagaata atggaaatct 2873761 taatggctgt attagccggt attattttta tggctgctac gtatttgctg ctgtctaaaa 2873821 gcctgcttcg cgtcattatc ggaacagcac tgttaagcca tggcgttcat ttaatgcttt 2873881 tgactatggg aggattaaag aaaggcgccg ctccgatttt gagcgagcat gccaaatcat 2873941 ttgtcgatcc gcttccgcaa gccctgattt tgaccgcaat tgtcatttct tttggcgtta 2874001 cgtcattcat cctcgtcatg gcctttcgcg cttatcagga attgaaatcg gacgatatgg 2874061 atcaaatgag gggaaatgat caacatgaat aattttgtta ttttgccaat cctgatcccg 2874121 cttttgtcgg ctattcttct gattttcatg acgaagaatc ttatgctcat gagaatcttc 2874181 agcacggcgg catcggccat cgggattgtg attagcggca tacttgtaca gactgtcttc 2874241 acaaaaggca tccagacact cagcctaggc ggatggaaag cgccgtacgg cattgtgctt 2874301 gccgcagacc aattcgccag ccttctcgtt ctcacaacag cgatcatcgg tttattggtt 2874361 gggctttatt ccttccgttc tgtcggtgaa aaacgggagc gctcctttta ctactccggc 2874421 gttcagttct tgcttgccgg cgtcagcgga gcgtttttaa caggcgattt atttaatatg 2874481 tacgtatttt ttgagcttct gcttattgct tcctatatgc tgattgtatt aggcggcaca 2874541 aaaattcagc tgcgggaatc ccttaaatat attgtgttta atattgtatc gtctgccctg 2874601 tttgtcatag gggtcggctt tttatacgct gtaaccggta cgttaaacat ggcggatctt 2874661 agcgtgaaaa tcagcgaatc aggacaaacc gggctgatca ctgtgattgg tgtcctgctg 2874721 cttttggtat ttggcatgaa gggcggaatc ttccccctct acttttggct tccaggctct 2874781 tattacgcgc caccggcggc aatctccgcg ttgttcggcg ctttgctgac aaaagtcggg 2874841 ttatatgcga ttacgagggt tttcacattg atttttattc acgatacagc ctttacccat 2874901 cagttgatga tttggctggc ggcgctgact gtgatttttg gtgtgatcgg ttcactcgct 2874961 tattcgaatg tcatgaaaat tgtgatctat aacattatta ccgctgtcgg cgtgattttg 2875021 ttcggtgtgg cagtacacac ccccgcatcc attcagggcg cgatctacta tctgattcac 2875081 gatatgctga ttaagggcgc tttgttcatg ctggcaggta cgctgatcgc attgactgga 2875141 accgcgagcc tgcataaaat gggcgggctg atcaaacgct atcctgttct tggatggatg 2875201 tttttcattt ccgctatttc tcttgcaggc attccgccac tgagcggatt tgtcggcaaa 2875261 tttaaaattg cagagggcgg cttcgcagaa ggtgaattta cgatatccat gctgattctg 2875321 ctttcgagtc tgcttgtact gtactctgtg ctgaggatct ttatacatgc gttttggggc 2875381 gaagaaaaag aaacgccaaa accaaatcat cgaacagcta aaggacttct ttatccggca 2875441 gctatttttc tcttgctgtc ccttctcttc ggattgggta cagaatgggt gtcgccttac 2875501 gttgatcaag cggccgagac gctgctgaat ccggaaaaat atatcgaagc tgttctgaag 2875561 gagtagatcg catggcattt caaattttat taaatgtgtt tctcgctttt tgctggatgt 2875621 tcttaagcaa cagtccaagc gccgcaggat tcattacagg ctatattctg ggaatgctct 2875681 ctctcttttt cttccggcgc tttttcactc gccagtttta tctatggaaa ttgatttcta 2875741 ttatcaagct ctgtttcatt tttataaagg aactgtacct tgccaatgtc agtgtgatga 2875801 aatcagtctt atctccaaaa ctgaatatca gaccgggtat ttttgctttt aaaactgaac 2875861 tgacgaagga ctgggaaatc accatgcttt ctctgctcat tacattaacg ccgggaacct 2875921 tggtgatgga tatttcagat gacagaacaa tactttatat tcatgcaatg gatatcgagg 2875981 atgcggaaaa agcgattttt gacattcggg agtcatttga aaaagccata caggaggtga 2876041 gccggtgatg tttacgctga tcctgcaaat cgcgctcggc attatggcag tgtctacctt 2876101 tttgtatgtc attcgtgtca ttaaaggtcc gactgtgcct gaccgggtcg tggctctgga 2876161 tgcaatcggc atcaatctga tcgcaatcac ggcgcttgtc tccattttgc tgaaaacaag 2876221 tgcgtttttg gatattattt tgttgctggg gattttatcg tttatcggaa cgatcgcatt 2876281 ttccaagttc ctggagaaag gagagattat cgaaaatgat cgaaaccgct aaggtcgttg 2876341 tggctgtatt cattttgctg ggtgctctta tatgcctcat tgcttcattt ggcgtacttc 2876401 gccttcccga tgtgtttaca cgcgctcatg ctgcttctaa aggctcaaca ttaggtgtca 2876461 atatgattct gctcggtgtc ttcttctatt tgtggtttgt gacgggggag ctctccgcta 2876521 aaatcctgct tgggattctc tttatcttta ttacgtcgcc tatcggcggg cacttgatct 2876581 gccgtgctgc gtataactcc ggcgtcaagc ttgatgagag aagtgtgcaa gatgactata 2876641 acggaatcag aaactttgtg attaaacgaa aagaggattc ttatttataa aaataagcag 2876701 ccggacaggc agagttccgg ctgttttttt atttcttgat gacagccagc gtgcatctgg 2876761 atatacagat cagcctctct tgctcgtcat atatgtgaat atgatagaca atcgtcgttc 2876821 tgcctatatg aacgggctcg gctatcgcct ttaccgttcc ttcctttaca gattttaaat 2876881 ggttggcgtt aatctccaaa ccaacacaag cttgcgttgt atgatcaatc aggttctgtg 2876941 cacctgcgct cgccgcggtt tccgccaggg ccactgaagc gcctccatgc aaatatccga 2877001 acggctgtac cgtccgatga tccaccggca tgaccgcaac gcatcgttcc gctgtgtttt 2877061 caacaatctc aataccaagc gcttcaagca atgtgtgctt catatccatc tctacacccc 2877121 ccaacattta aagtacaccg tctgatttcg caatcaaaac cgcttccgtc cgtgaaccga 2877181 cattcagctt attgaaaatc gatgtcaagc tgtattcaat ggaccgcttg cttaaatgaa 2877241 gggcatctgc gatttcttgg tttgtaaatc ccttttcaac ttcttgaaga atcaggcatt 2877301 ctctaggtgt gagcacatct tgttcttttt gagaggaagg agccggcttt gttttttgct 2877361 gagtcatcag ctgtttaaag taagcaaaat cgactaaaat ttctccgttg agtacgtggt 2877421 atatgtattg ggtgatcttt tctttagatt ccgttttgct gatggcaccg tgcagacccg 2877481 cacgaatcgc ttcctcgaaa taatcctcga cctcataacc ggtatacacg ataattttac 2877541 aatgaggatt ctcttgtaaa atctgtttag aaagctccat cccattgacc tcgccgccta 2877601 gattcagatc cattaaaatg agatcatatg acgagaaatc atgctgcttg ataaactgtt 2877661 cgctcggttc aggactgaga caatcaacag acaaattcga atccgtttcc aaaattgtct 2877721 tggtgccttc catgacagcc ggatggtcat caatcactag tatctttttc atgttttcct 2877781 cccttttact cactcttttc cattttataa aaaagacttg gcctgtgcca agtcgtttcc 2877841 gttataaatc cattacaatt cgatttcaat atcagcctta aagccctttc cttcacttgt 2877901 ttcaatccga aggcgcccat ctaaagccct gactctctcc ttaatgccag aaagccccat 2877961 gctcatggaa tgctcagtat ttttttcttg atcaaaccca acgccatcgt cctcataatg 2878021 aagaacgatt ttgttttgaa tactgatgag cataatcagc acatccgtcg cctgagagtg 2878081 cttgaccgca ttagacagaa actcttgaat gatccggtac aaattcagct gcgaatccag 2878141 atcaagggaa gccgtaaatc tcccggtatt taaacggata tgaaacggaa cccgctcctg 2878201 ctgctgcgcc accagcttcg acagcgcctt caccaatcca agatcataca gaagctgcgg 2878261 ccgcagctca tgacacgtct ccctcgtcat cgaaatcaca tcagacatct gctcattcat 2878321 ctgtacaagc ttgtcctgca cctcttcacg gcacggatta tcatccttct tgaaatcacc 2878381 caaaaacagc tcacactggc gttttaagga aatcaaatcc tgaagaaccg aatcgtggag 2878441 atcgcgggcg agtcctgaac gctgtttttc ttcgattgca aacattagct ttttcagcca 2878501 gatggggttg gttccctctt gttttaagtc cttcaaatgt tccatgagct cctcaatatg 2878561 caggacattt tccatggaca cacttgtata aaaagacagt gttttcagcc acgatatttc 2878621 atcacgtgtt agccggggag tgttaatatt agataaacaa agcagaacat aagaactacc 2878681 gcctcgttca ccaactttca taagaaagcc ttgattgact tctataattt tcccaatttc 2878741 tgaagttacg ttttcaaatt cctcttgata aaaattccag tccggtccaa cttcatgctt 2878801 atctaaaaat atcactttgt gatcaggagt aacctcaaag gtataagctt tgcttacaag 2878861 caaaacatcc agtatagtat ttttcagttc tttaaaaact tgttgaagag aagttacacc 2878921 cctcattagc tgagtatatt taaaaatact gtcctgatag ttgaattttt cggagaaacg 2878981 ttttaaccga aatttaaaat ccatgacctc tttaaaataa aagacagcga acatgacaac 2879041 gaaaaaaaat acagtttgac gcacagggtt catctggatg tccattacat caaacagaac 2879101 taatgcacca actattagaa gagttggtat catggcaagt agagcatagt atctcattct 2879161 tcctaagata aactctatat caaacatctt attggctaca aattggtata ctaacccgaa 2879221 cggaattagt actagtaatg acgccgaagc taatgccggg aaaatataat tacctgtaaa 2879281 tattattgga agaacaaaaa atatcaaaaa aggcgcaaat gaaagagtgt ttgttaaaat 2879341 tagtaattta agaataaacg aatgctcagc atatttatat ttattaagat gtaagtatat 2879401 cgctgaaaaa gaaaatagag tcaaagttgc aaaagaaacc aaattaagag ttgctaaaaa 2879461 atcaatatct acttgtaaat agtcttgaaa aaactcaata ccaagattaa atattggtat 2879521 gatataaaga aaagaaattc tattcaaaaa agttttacct atttctccaa ggtatctttg 2879581 tataaattga agataaagaa taggagaaga tataaaagta aacaagttaa tataccgatt 2879641 gattatatgt cctctaaatg gtccgcctgc acttatatat gctatcgaaa tgtctaataa 2879701 caatagaata agaatatagg cagcaaatga tctccttttt ttatttactt taagtatata 2879761 aaaaatacat attatgctta aaaaataaaa aaacaaagga agtacgaaca gaaaaaaact 2879821 ataaggtcta tttagagtaa ctaaatcaaa atctttgaga tgaatctttt ttccacttct 2879881 caaaatatcc agactgttaa tatgactcaa atatccccat ttcaaatgtt tgtctgaagg 2879941 tttttcttta ttaattttta atatgatgtc tccctgtctc agaccaacaa attgtccata 2880001 tgaagattcc gatatttctt ctatcataaa ttgactttta tcatttttat gaatcttagt 2880061 cccaataata attccattca tactgatata agttgtatag cttatataaa ggatactcaa 2880121 aacaattaca gctattgtga atttttttat taagttcttc aatattaatc cacctattaa 2880181 tcaccccatt gacgggttat tggatcagcc agataataat cattataagc tttaattatt 2880241 gtttcagttt cttgcacatc aaaacctata aggcaggctt ctttattttt caattttttt 2880301 aaagcctcag gataatttaa aaagtagtta attaggtctt gcatcttgta tccccctttg 2880361 tataacttaa taagcattcc tttattagct ctttttttct ttatctaaat ttaattgttc 2880421 tatagcagaa atacatttct gtttatatat ttccaataat accgaaatgt attgagtaac 2880481 tcccgcttta attaattttt cttggaattt ctctttatca agtaacgatt tataatataa 2880541 gtctttatgt gaaattaagt ataataaatc ttccgaagca tcattaaaaa ggcgcttaag 2880601 atataagtaa atcagtgtat gtttgttttt ttcaatatca ctgcgatttc cggataaaag 2880661 aacataataa tctccagaaa tttgagctat aatcccttta tagtaggaat atctttcaac 2880721 tgtttcatta tattctcctg tagccaataa aacacctgct acatttgcta gtgcaatcag 2880781 acttccacat tttaatctaa ttacttctaa actttcatct tctgttttag atttattagt 2880841 gatatcgtca tgttgacctt gcatggcctc gtttacgtat tttaaaacat atttaaaaat 2880901 tagaggattg ttatttaatg aataaatact cgttaatcct actgtataca aggaaagtgc 2880961 tgcatttaac gactccgagc gattaatttt catccataat gcatggtgat tatcttcatc 2881021 ttcaagatca tccataatat ctgatgaaag aataagaatt tctattcccg cgccaagcct 2881081 tgttgcaaca tctaaattct cccctccaaa aacaacataa tgtaagattg tggattcagc 2881141 aaaggagaat gtttctttag aatcaataaa tgagtaaaga agttgtgaca aatcctcgtt 2881201 aaatatgttt tgctccacaa tctccttcat tttctccttg atccggacag aatctaaaca 2881261 tatctgctca ataacgactt cccccctccc attccatttt actaaatggg acatttaaag 2881321 gacagcaggt ttttcgtttt ttaacaatca tataatactt tatccattta ttgtatcggt 2881381 agaacgaaaa aaaagacttg tttccaagtc tttttcacga aattttcatt gcataattgt 2881441 atttatcgag ttgatcaatg cttttgttaa tgtttcgtaa tgaatctgtc gtttctttaa 2881501 tatcaagttc gagtcggaat aacaattgtt ttacttcttc aagtttcttt tccatcgttt 2881561 ccacactcct ttttttgaaa gatcaatgaa ttgtgtatgg tgaacgagtc ctaggtattt 2881621 gatctgttac taatagtgtg tctgctttcg gctcattttt caccgaaaag tatgcaaaaa 2881681 agtcctgcgt gacaccgcaa atctcaatag gtccttatac tcaaaggaat cacaacaaga 2881741 acgggactat ctttctatgc gaaagagcgt ttatatgtgc tgaaattgag aaagattctt 2881801 aatctccttg attttaacgg gtttcgcatt ttcactaagc aagactatag tccttcatac 2881861 cgtattttca aaattgaata tgcgattctt ggcgtttcct gaccgacaaa caccgaaaaa 2881921 gaccgcaacg ctaaagttgt ggccttttcg ctttgtcata ttcggcaatt agggatctat 2881981 acatatagaa acatcctttt ttgcgaggtg ctcccatgag atatcgttat ccctggtttt 2882041 acgtgtatcc gtatgaggta cgccgtccgc ccgctcctgc caacaatatt gataccttta 2882101 tccgttcagc gaagcaggcc gcagggatat ttgcggatgc ccagctcgtt ctcagccgca 2882161 ttgcgggctc gcgggagctt tcgcgccgca ttctgaccgc agccgaacag tctgataaac 2882221 aaactataag gcgcctgatc aaacaaatgg gcgtccggca tgaagtggat acggtcttta 2882281 atcccgacgg catctatatc agccttatcg gaacgcaaag ccgaatgatt cttgctttgc 2882341 ggtggtcaga ggaccgcaat cattttgcgt ccataagatt atgacaccat tccagagcct 2882401 ctaaataaca ttcatacgct tcttctttgt ccagttgatt gcctaattct gagcaagtgt 2882461 cccagttgtt gctttcaatt aatttcacaa gctcaagcat ttggtagtag tcgttttgat 2882521 ggcctaataa tgcttgcccg acttcatctt ttaaaggcaa ttcttgaaca atttcctcta 2882581 tttctctatg caggagggtg tctatgagag aaaacattcc gatcagcata taagaagcag 2882641 gctgcggccg ggatgtcttt ctcgccagca gttcgcaaag ctttgctctt atcagagaaa 2882701 tcttaatgat ttcgtgcttg ctggaatgcc ctttcctgct taaatcctta aaggaaagaa 2882761 tatatatcca ccgtttgatt tcattaaatc ccagcagcat aatggcctgt tgaatgcttt 2882821 caattttctg gctcaaacgg ctgtgggatg agtttaaaaa ttttaaaatt tgataggaca 2882881 gtgataaatc ccgctctatg tactctgtca cacgctttat gttaggctgc tctttactca 2882941 gttcgttaag cagttcatag taagaataga aatgagtcga taggtcatgc ccgctgatga 2883001 tgcgcggctc gctgaaaaag tagccttgga ataattgaaa gccgtcttgg accgcctgtt 2883061 tatattcttt tcgggtctct actttttccg ctaaaaaaat caggccgcgg cagccgtagg 2883121 tttgcaaaat tgttctgcgt tccattcgtg ttgttttgag aaaatcaatt ttcaatatat 2883181 caatatagct catgagtttt tccagtaagt cctcatcttg cggatttatt gcataaaaat 2883241 catcaagcgc cagcatatac cccatttttt tcaattcttt gcatctagaa atgagggccg 2883301 gcgtgatcgg tatatcttca aggatttcaa tgacaagctg tttcggattg aaggaggtgg 2883361 gaagattcga aaacatcagg ctttccgtaa aattaacaaa acagcgtttc ccttccgtca 2883421 gcttctcaat tccgatgttt aaaaagctgt tgatcaccaa atctgttgtt gcctgatcgc 2883481 cgtctttagc gctatacacg ttctcttcgc tttctctata cagcagttca taagcaacaa 2883541 cctgttcttt tctattaaaa ataggctgtc ttgcaacaaa caccctcatt gatttatccc 2883601 ccttacaata cgcgcggctt tcacccctaa gtatatcaaa taatttgacg aaaattgtct 2883661 aaacatgaaa aataatatat acataaagaa aactggccct tcgcgaatga aaggccagtt 2883721 tttctttatt cttcctcaag ctcttcttca attctgcttt tcacttcgtg gatccgctgc 2883781 attttattgc tccagcagtc ctcgcttaaa tcaaccgggt attcctccgg cttgctgatt 2883841 ctcttatatt cctcccaaag caggctgagg ttatcctgca catactgctg tatgtctgaa 2883901 atctcagggt tttggtagca aagaataccc ttctcaaaaa tcagttcatg aagatccttc 2883961 gcataaaaat tcgtgacaaa tttgctgatg aatgtatgaa ccgggtggaa cattctgagc 2884021 cgcttctgat cattcacctg ctcatcataa agcgcaatat agtcgccttc agaatgatgg 2884081 ttggactgat taataatgcg gtagactttc tttctgcccg gtgtcgtcac tttttcagga 2884141 ttggacgaaa ttttgatcgt gtcgaccatt ttcccgtctt cttcaatggc aacgagttta 2884201 taaactgcgc cgagagccgg ctggtcatag gcagtgatca gcttcgtacc gacaccccag 2884261 acatcaatgc gcgctccctg agcctttaaa ttcataatgg tgtgctcatc caaatcgctt 2884321 gaagcaatca ccttcgcatc tgtaaatcct gcttcatcaa gcattttccg ggcttttttt 2884381 gacaggtacg ccaaatcgcc gctgtccaga cggatgccaa tgaaattaat gcggtcgccg 2884441 aattccttgg caaccctaat cgcgttcggc atgcctgaac gaagcgtgtc atacgtgtca 2884501 actaagaaga cgcaatcctt atgtgtttcc gcgtattttt tgaaagctgt atattcatcg 2884561 cggtaagcct gcacaagcgc atgcgcatgt gtgccggaaa ccgggatatt aaagcgcttt 2884621 ccggctctta cattgcttgt cgcgctaaag ccgccgatta aggctgctct cgctccccac 2884681 atggccgcat ccatttcgtg cgcccgtctt gttccgaatt caagcgcaac ttcatcaccg 2884741 atgacgcctt taatccgggc agcctttgtt gcgattaatg tttgatagtt cacaatgttg 2884801 agcaaagctg tttcaatcag ctgcgcttct accaggggtg cctccaccct cataatcggc 2884861 tcattgttaa aaacgagttc tccttctttc atggagtaaa gtgaacctgt aaaagataag 2884921 ccgcgcaaat attcaataaa atcttcatga tacccgagtt catcctgtaa ataactcaaa 2884981 tcgctatccg taaacttgaa attttccaag tattcaatgg ctttttccaa gcccgcaaat 2885041 acggcatagc cattttcaaa cggaagcctt ctgaaaaaca gctcaaaaat cgctttcttt 2885101 tcatgaatgc cgtctctcca gtacgtttcc gccatattga tctgataaag gtctgtatgt 2885161 aatgacaggc tgtcatcttt aaatccgtac tctaacactg tttttcccct tccttactct 2885221 gccacttgcg ctccgatgct gtttgcaaaa tgggaaagag cccatgcgtg cccctcctga 2885281 ttaaagctgg caacagcttg tttatgcaca acaatccgaa aacctttgtt gtatgcgtca 2885341 acagctgtat gcaacacaca aatatctgtg cagacaccgg caagatgcag ttcgccaatc 2885401 tgccgctctc tgagtttgag ctctaaatca gttcccgcaa aagcagaata tctcgttttt 2885461 tccatgtagt aaacattagg ttcatgttca tgtttctgat atagaggcaa aagctttccg 2885521 tacagatctt ttccttccgt gccttttata ttatgcggag gaaaaagacg ggtttcaggg 2885581 tgatattgat ccccttcatc atgagaatct actgctaata cgacgtaatc accgtttgtg 2885641 atgaattctt tagttaaatt gacgatcgcc tcttcaatca ttctgccggg ctccccgcag 2885701 gtcaattttc cgtcactcgc cacaaaatca ttcgtataat caatacaaat aagtgctttt 2885761 ttcatagccg gcctccccgc catcagtatg agaacattat atcttatctc cagttgtaag 2885821 tgaattgcca tgaacaaaaa gacaaacggt ccgtttgtct cttacgattt cagtactgac 2885881 cgattataaa tgtcgtcctg aatatatatc aattcacgat tcacagcgat atcagccgca 2885941 atgacgatgc ctaagggcgt atgaaactgg agatcagata caatcttgaa aggcactccg 2886001 taccggctcg ccatttggat ataagaagag taagactgat actgaagctc tccattaatc 2886061 aaaagggtga cgttatggct gtttttcagc tcgtgctctg cctctttata cggtttgctt 2886121 ctaagcacct gtcctttcgt cagtgccaaa acgactcttt ctcttaaaga gcctaaaaac 2886181 aaatggcgct cgtcaggctt tgtctccaaa ggcccataca ttccttgctg caaatagaga 2886241 tccattttat cttcactcaa aagcctgtcc tcccgtcttg tttgtcttca ttatcacctg 2886301 atcaggcagg agctaaactt tcaagcgccg tttacatttc tgttacccaa tgaatgattt 2886361 ttttggccag ctcaccagca ggggtttcct ctgtatgccg gcgcaacgac gcttccagcc 2886421 gttcaggcag agttgcttta tcttcttcat aggaaatgat cgtgctccac tccagctgcg 2886481 gtaccgctac aagcgtgcgc agttcttttc tgttttcatg cagatacacg tccgtgatca 2886541 ttccggtttg cgtattgata tttgcttttc tgattttcat aacatgacct ctctattcaa 2886601 agactaccca tattatacaa taaaaaagca acagcctctt gtgaaaaggc tgttacccgt 2886661 taaacgaaac tgtttcatca gtgatatcgg catctttgaa gagagtttta ctcgtttggt 2886721 tgttaatctt cacaaaatca ccaagctgaa atgtgcctga ccccgcccct gaatgagcga 2886781 cgcttttggg cgaaatcgca aatacgtctc caaagcttgc cgcggcatta tccgtaactg 2886841 acatgatata aatcggcccc acaattgcag gcatttcccc acctccgcat tgatttacag 2886901 catcatatgc aaggagccga taatggtgcc cgcctattca gctggctttg cgttttcctc 2886961 gagtcgtgac cgctggcgca gcttgatcaa gcggacaata ttcaggaaga acgccttcac 2887021 taccgcataa accggcaccg ctaaaatcat gccgagaatt ccgccgaagc ttcccgctcc 2887081 gattaatagc aaaataatcg taagcggatg ggtattcagc cgctttccga tcacaagagg 2887141 agacagcagg tttccgtcca gctgctgaac gatgacgacc acaataatcg caaacagcgc 2887201 tttggccggc gagtccataa aaccgacaat gacagccggc gcggcaccga gaaaaggccc 2887261 gacataggga atgatattgg taatcgccat gacaatccca agaatcaggg catacggcag 2887321 tccggcaatt aaatagccga taaaacacgc tgttccgaca aaaagacaga ttaacagctg 2887381 cccctggaaa tatgccgcaa gcgtatcgga taaatcttta aaaatcttta agccttctgt 2887441 ccgataagaa gccggtagaa tttttactgc caaatgcgga aagcggtgtc cgtctttcag 2887501 catgtaaaaa aggataaatg gaacagtaat aataacaagc gtgatgtttg tcacgacacc 2887561 aaacaccgca gataaactgg acgtgatatt ttgcggcagg ttttggagaa aacttgtcaa 2887621 tgactgttca atttttgata tcgatacata atcctggttc atcatccagg taaaccattg 2887681 agaatgggac aaatcctttg tcagcgcctg aatctgtttt atataatcag gaaggttgtt 2887741 aaacagccct gtcacctgtg cggtgatgat aggtccgact gacgctgaaa taaaggcaag 2887801 caaaccgata aacagtaaat agatcaatag aatggataat gtccgcggaa tttttttctc 2887861 aagcaggcgg acgaccggat taaatatgaa atacaaaatt cccgcaatta gcatcgggaa 2887921 aaacaatgtc gagataaaaa caataaacgg ctgaaataca aatgaaactt ttgttgctac 2887981 aaaaataatc agcaaaacaa ataaaatctg caatgtccaa aaatggactt ttgatttcaa 2888041 caagctttgt tcctcctagt ttttctttgt ctgtcagata aaagaactta taccccatca 2888101 ttgtaacaaa aatgaactca tatcagaact cttaatataa tgaaaggagt gttggtgatg 2888161 aaggccgtga catacgatac agattcagaa ctggcttata tctatgttct tcctccgaaa 2888221 aagaacagga atgtacggac tgaggagctc agagtcaatg attgtctcct gctggatatc 2888281 agccaagatg gcaaaatcgc cggattcgaa tgttttggtg aggcagcaca cctctgtgcc 2888341 ccatttgccg ggaaatcccg gctgtatgta aaagattcag acggttatca ttttcgggtc 2888401 tgccagcatg cttcagtccg ttcctgctat acggtgtacc gtgtcacttt ctgtttttca 2888461 gatggtgact atcaggaatt tgccggcttt gaccttgatg gaacaatgta tcatagtgcg 2888521 tttttacagc gcttaactga aaaataggac gtcctgttgt acgcctattt ttcatgcgca 2888581 agcactgtta gacccgctca ctgtaatctg gggtgacgga aatcatgtgc tggattctga 2888641 tcaaacaaac agaatttcgg gctccttcaa ttgtgatatg gtcaggtttt acatcgatca 2888701 gtctgcctct gaccgtatct cgtactgtct gtataacgaa ccttgagccg atgagctttt 2888761 taatggtctg atagacataa ggatcgacta aagagaccag ttgcggacta ccttggttga 2888821 ccatactttt atcccctttg tgtgttttat ctcagcttat gccgcgctta tggataatga 2888881 cacaggctta cctgataaaa caaaggggtg cggagatttt aggagaatac gtttggaggc 2888941 gggtgtaaag gaagtatcga tgaagcggag acagcgaaga aagctggcgc tgttccgtac 2889001 ttatacaggc tttatcacgg atgcctgggc ttggtcgatt aattggtcca gcttttctat 2889061 tttttttcgt gcggttgaag gatcaatttg gcggtaatga tggtggccgc ccggctcttc 2889121 atccagttcg tccgcttttt tgacaatctg ctgcagtgtg tttttatcta attcgccttc 2889181 aggcaaatag gaatctgtat gaagcaaaat ggctagtgca atctcttttg ctgctttcgg 2889241 ttcctcgcca agccgaatca gaagtttatg cgcccgttcc gcccctttaa tggcatgaat 2889301 gtcatttctt ttgtatttct cataatccca ctttccgtct gtataccatt cataatggcc 2889361 aatgtcatga agcagtgccg cttttgctgc taaatcagga ttaatgtcag ccttcacaga 2889421 cagcctgtat gcatgataag cgcaggcaat cgcatgtgcc acgccggaac gctgaagata 2889481 tttttgtgca attggatggg tgaaaacatc cattaatgta acctttctca tggaaacccc 2889541 tcctttagat atttttagaa tcctaacata atttgcagag aaactcaatt cttatgtcac 2889601 atcattttga tcttcttatc atcattgtta taccctaaaa gcaacgtttc agtcagtata 2889661 tgcggctgtt caataaaatg cgctggctgc agccttttgt ataaaaaaaa gagcagaaaa 2889721 tatctgctct acaaaaactc tttaatatca taaatgcggc cgttttccgt ccctttttct 2889781 agtaaagaaa gcagcgtgcc ggcaataaag tccggactgc gaaggcttcc tgtttcattt 2889841 aatttccgga atcgttcaat gtggtggaaa tcctttttcg atgaagaacg gatgacggcc 2889901 tgcatctcag tgtccatcac tccaggtgag aacgaaatca tgttcaccgg cagctcttca 2889961 tcctcctgtt caaatccgaa tgtcctcgta aacatgtcga gcccggcttt tgaactgcaa 2890021 tacgcgctcc atcccttata tggatttttg gcggctcctg aagtaatgtt gacaaccgtc 2890081 tttttgccgc tgtatgaagc aaaccgtttt gtaaacagct gactcaaaag cacgggcgca 2890141 gtcaggttca gctgataatg gcgctgaagc tcgtcaagag acgcttcgcc ggcacgtttg 2890201 atcggcgtta ccattccggc gttattaata agggtaatac cagaataacg atctgaatcg 2890261 atggatgaga gcaatgtttc aaattgctgt tcagcttctt cgagattgat gaggtctatt 2890321 tgatgctgcg ttagtttttt gtgagagaca tctgttttcg ttctggataa ggcatggact 2890381 tcatgcccct tttctaaagc ctgtaatgca atggcttgac ccagcccttt tgacgctccg 2890441 gtgatgatat aaagttccat tggaaacctc cttttccgtt attattgtac ggcacctctt 2890501 ttacacaaca caagcacgcg gcctacgcct tcttgttttc ctgcgctgtg acttttggga 2890561 tgaggaacac gatgcctgca attccgagca ggatcagtac gacatagatc atcggcagca 2890621 gcaatgatga tgtttcttgt tcatcttctg tttccgttga tgatgtcttt gtcattggtt 2890681 tttcagcaaa agtaattcca agctgtttcg actgggccgc aatcgtgttg gaatcctcgg 2890741 catttgttga tgtaaacaaa tcttttatca gctcggcgtc cttgtccttc ggtttatcaa 2890801 aagtgatatc cttttgttcc tcaggcagtt ctgttttttc ttcatagtag gtatcttcat 2890861 gcaaataatt cgtatcgatt tcgatgtctt ttttctcata ctggtttggc gcgacatctg 2890921 tattttcttc agtttgggca gccgctgcag agggtatgaa aagggaaaag gagagcatac 2890981 aaatcatgat ccccttttcc atgctgcgat cacgcttcat acgtttcatc gctttctgct 2891041 gtgtgttcag ccatcaaccg gataatcagc ggcagagcca cggcaatcac cgtaatgatc 2891101 agcagaactg ttattcccat tgtaaacaag tgcccagtac cgtactggat gtcgatatat 2891161 actttcgaaa ccggatcttc aaatgtaaag ttcggcatga tcaaatcaat aagcggtgcg 2891221 acatagaata ggatcattgc tgctgaagca acccagccag ggattgatcc gaatctgaat 2891281 gccgtccgga tgaaggcaga gcttgcgacc agcaatagaa tcgtaaacac cgaccactta 2891341 atcgtctgat cgtccggcag tgaataaata ttcaagccga acaagctgat cataagtccg 2891401 acaaggatat tcagaattcc gaataacgct cctttgacga gaagcggtgc gttttggtaa 2891461 tacgagctga aatagccgat taacagactg ctgatcaaca caatgacaag gatgacaacc 2891521 ggaggtaccg tctgaatttt ttcttccgga acctctccgc tgattttaag cggattcgct 2891581 aagtaatcat atacatagcc attgttttgc ccgtctacta atgtatttcc gagtatgccg 2891641 tatacgtcat ttcgcacgag tttcgtggag gcgacatttt tcccccagtt gttgtttaag 2891701 gtgtcggctt tcgcttgaac atcattaacg ctttgctgca tgttggttgt gtaatcaatg 2891761 atgccggact ggcgatcaga caatgaaccc atcatgtctg acatttgcag cacttcctgg 2891821 ccgaccgtat cttggacact cagtgccatg gtaccagaca gcccatcgtt gctgaacgtc 2891881 gcagattcct gtgttgcgcc cgttacaagc tgttctgacg cttttgcggc actttcagag 2891941 attttcgtca gttcgtcgag aacacctgct tgagagtcac ggatatagcc gctgtagtcg 2892001 tccgcaaatt tggtcatgcc gtcgatgaag ctgttaatat cctcatctgt ttgcatcgtg 2892061 ttgtttttga gagcttccca gctggctgat tcttcaggtg tgagagccag gactgattgg 2892121 acgttgccat cttgctcttg gatgacttca cctttaataa tagtcaaaga gcctagatcc 2892181 agattatcat ttagcgtaga cttatataaa tttaaagagt tgtaatactt catcaagtta 2892241 gaaatattat cagtttcaat tctacttgaa aaaattgaac ttagtttttc tttctgatct 2892301 atatagcctc tactctgcaa agtttgtatt atttcgtctt ccaaattgta tattaaccta 2892361 taagcatcat tgacattatt atcaaaatca accaactttt ttgttaagtc accaatttga 2892421 tcatttaatt ttgaaactgt tttatttaac tctttaattt cttgatttaa ctcatcaata 2892481 tgtttctcta gtttgttgtt atgttcctct tgtttttctt gaagtgcatt ttctatttcc 2892541 tctaatttta tcgctgcttc gttcagacgt ttttttgcac ctgaaatatc agtttcaccg 2892601 tcagctccgt caccctgtag cccatcactt tgatttgagc catcgttttc atctgcgagt 2892661 tcaatcaaag agaaatctgt tttagaggtt cctgtattct ccgtgtttgt atcttgttca 2892721 ggaacgtttt ttgaagattc ttgatgtttt tgtcccgttt caatgttagt ttgaacatca 2892781 ttttgtgatc cattatcttg agtaccctct tctgatgagc cagtatcttc atttgttggc 2892841 tgatcatcgg atgttggaat atcattcgac ggttcttcag tattaggaga atcatcggtt 2892901 gatggttctt cagcatcggg tgttgttggt ttttcttgtt caggttcttt taacccttca 2892961 gagatatctt taatttcagt tgcaacattt ttgagctcat cccgctgctt ctctaaatcc 2893021 aattttatat cttcaatatc ttccttatct gtgtcatctt tattatcaga tgtgtcttct 2893081 ccatcttcct tttcgtcgct ttccttaggt ttaagtaaac taaggcggtt cttcccgata 2893141 ttctcttgca attgatttaa attttgatat ttaatagctt catattgact tttatatcga 2893201 gatagaaatg cattaaacat gtcattctca atttttttca tacccatttc ttgcaatggc 2893261 acttgatttt gccttaactt ttcagcattg ttcaacgcaa ggtttgtcag tcctatttgt 2893321 gtcttcgctt ggccgatccc ggttgccaat ccgctcatgc gttcgctgaa ctgattcgcc 2893381 ttttgctgtg cctggatggc atccagacct gtccggattt gctgctgtgt tgaatcctgg 2893441 gctgccaaaa gcagcttttt ctgattctct tgatattctt tgtacctttc aactgtatca 2893501 atgaattctt tcagcgtgtt tttggcttcc tccgccgtag aagctttttc ttttgtcgtg 2893561 ccttgcgctt cattcattga tttcttcagc tcatcgatta agtctttttg ctgtttgatt 2893621 tcacctgcta aatcattaga gcttggtttg taaaagttgt acatgacatt ctggaattca 2893681 gattctttat tgacgatctt gtcaaattct cctctgatgt tgtccacttt ttgcgaaaca 2893741 aaattccagt ataaggccga catttttttg ttcattgtct tttgggcatc ctcaagctca 2893801 cgctgaactt tttctttgtt aaccgcattc aggttatctt gaatgctgaa ttcgagcgtt 2893861 gccttttgag gatggtcttt gtcatagctc aaaatgtttt ttgagaagtc tgagggaatg 2893921 tagacaatcg catcgtattt ctttgaagcg agaccggtct cggccgcgct tcggtttacg 2893981 accgtccacg aataatcagg acgttcaccc agaacggccg ctacttcctt gccgaactgg 2894041 gcggatttgt cctcttcatc agactttacc tcatcactca atacgcctgt gtcttcattc 2894101 accaccgcga tttgccgggt agaattgact gcttttttcg ttgggtcgtc tccgataaat 2894161 cggaaaaaca acaccggcag cagcaaaatg atgatgacgg cggatattaa cttgatcaag 2894221 ctttttcgtt gttctgtcat ctagcactct ccctttcagc agaacataaa ggaatttgaa 2894281 ctttttgctc cttcccgttt tccacaacat atccgaagcc cggctgaatc tcaggctcct 2894341 gtctttggta cgggagagga atgacatttt gctcagactt tttcatcagc agaatcgcgt 2894401 ggcggatttg cttcatctca gtcgtcaagg agtcatagcc ttttgagaat tcgctgtggt 2894461 ttccgcccgg gataaagctg aacccaagat gagcgtatga tttcatgaag ttagcgagac 2894521 gatcttgtat tctcgtatca atcgtctgct ggaatctcgt tatcccgtca atcatcagca 2894581 cgacttgtga gaatcgcaga ttttgtgcgt ctccttggcg gacggcttct acatacatgg 2894641 cttctcttgt tttgaaaatg tcttctgctg tttcaatcca ctgctcaata tcttctttcg 2894701 tttccaaata tgaaacatct gattccttcg cataatgaga taagccgcgg tcaatcgagt 2894761 caaacaggcc gatcatttcg gtttcatcat caatcagatg ttcaagcatg acttttagga 2894821 cgtttgtttt cccgcgctga gtttggccta aaatcaggca gtgcttatgc ttgcccaaat 2894881 caaaatagac tgggctgact gtttcttcat gaagcccgat cggtacagat aaaggcttgc 2894941 gttccagctt gaagcggata gacaattctc tcgtcgacaa gctctcaggc agcatcggaa 2895001 tcggtgccgg ctgctccatt gaagcaaatc gcccttgaag tttctgtacg tctgatttca 2895061 gctcgttgaa catgccgata tcatcatcgg cgtcaacagg caggaacatt tgcgcgaaat 2895121 aaagctcttc cttttgaatg atgacgcgtc ccggaatcgg ctcaagattg aatttcggac 2895181 ggccgtaaat ggaatatcct tctgattgat ccatgagata atggacaatc tttgttttca 2895241 agttatttaa caatgactgg cggacagcat tcacccgcgt tgctgtcagc ataaagtaga 2895301 tacccaagct ttgtccgtct ctggaaagct ggacaaattc cgattcaagc tcatgcatct 2895361 catccttgac aatgtcaaag ttgtcaatgg tgataaaaat gaatggaagc tcttcttcgc 2895421 tcagcgcatt gtacattttg atgtggctga tttctttttc ccggaacaaa cgtttacggc 2895481 ggtcaatttc ttctttgatg cgaatcatga acttttcaat tttccttgac tggtccatca 2895541 ggaagtaatc cgcggtatgc gggagcttcg ctaatggcag cagcgttccg tttccgaaat 2895601 caaagatata gacatgaagc tcttcaggtg tgtatacgtc cgcaaaactc atcaggaacg 2895661 ttgcggctgc aatcgatttt ccgtagcccg aagagccgaa gatgccgata tttccatctt 2895721 ccatcatctt ataagcaatt ggcgcctgtc tttgcagatc aggttcatcg acatacgcaa 2895781 agtggaaatg gtctttttcg tttgaaggga aaagagtgcg cggaatacgt tccgcaagcg 2895841 gcggcagcca agggcttggc agcttctcga ttcccatttc atcttggatg cgttcaattt 2895901 cgtcaactac agcttcgatt tcggtttgaa cgtctttttt cgcgttatct tcggtatcaa 2895961 cctcagaaag cgggatcaga cccgtatctg tgacgatcgc gatttcatcc tcggtaccgt 2896021 agacttcctc taagtaaggc gccccgctcc atgcagattg gaacagctca tacacttcat 2896081 tgtttccgac ctgcaaatag ccgcggcctg ttacggtaat gtttgcggca tcgctgtttt 2896141 tcaaaatttc tttactgtcg gtggcatcct ggaccttgag cgctacttta aagcgcgagt 2896201 tactccagat ctggtcgtcg atgatgccgc ctggcttctg tgtcgccaaa atcaaatgaa 2896261 cgccgaggct tcgtccgata cgcgcggcac tgacaagctc cctgataaaa tcaggctcct 2896321 cgcttttcag ctcggcaaac tcatcagaaa ttaagaacaa gtgaggcatc gccacttctg 2896381 ctttcccttg cttgtatagc tttgtatagt cattgatgtg attgacttga tactggtcaa 2896441 acaggcgctg cctttttttt agctcgcttt taatggaagc aagcgcacgc atactgaagt 2896501 ttttgcttcc ttcaatattt gtgatcgtgc cgaggaggtg gggaatgtta cggaacggct 2896561 gcgccattcc tccgccttta tagtcaatta gtaagaaagc cgcttcatgc ggatgaaaat 2896621 gcactgcaag tgacaagatg taggtctgga gaaattcact tttccctgat cccgttgtcc 2896681 ccgcaagcaa gccgtgcgga ccgtgtgctt tttcgtgaag gttcagatac acaatgtcat 2896741 ctttcccttt atagccgatc ggcactgaca gcgacttcga cgattcactt gtcagccatc 2896801 tttgctgaat gccgatttct tttacttcct tcgcatgaaa aagctccagg aacgataccg 2896861 tttccggaat ggaattcgta atgccgacct ggtggttcag cgtccgcagt gtgcgtgaaa 2896921 accgttcgtt atcctcacgc tgatgatgat cgagacggaa cggaattctt accgcttttt 2896981 tcttttgtat taaaatgtcg ccttcatgct cattaatgta gcggacaaga gttgtaatgt 2897041 tttccgacaa gctttccttt gtttctgcag cgacaattgt cgagatgccc agatgctcat 2897101 gctgcccttc taaatattcg agaatgacat gctcagagat cagctgctga ttcgtgatga 2897161 caaatacaaa atgcggtttg aactgcagtt tttctttgtc atcttcgaga tcacgctctc 2897221 tgatcaattc gtaaagtgaa gacaggagct gatctcgggt ttgctcatta taaataaatc 2897281 cttttgcata aatatggggc atttgaaatt gcggaagcca cttcatccac tcccagtctt 2897341 tatactcttc ttcatgaaaa ataaatacga aacgcaaatc gtgatagctg ttaaagaacg 2897401 acagctgtcc gattagctgg tgaatctcat ttttcacaat ttgtgattta ccgacaagcc 2897461 ccatcggacc ttctgccaaa tcgaccgtca ccggcgcatt acggatatct ttatagacgc 2897521 gttgcatgtg ctgcgatttc tccatgaggt catcgatatc acgattcgcc aagtctccgc 2897581 cactcatatt gatttcatag cttgacggaa ctgttcccgt cccaagccgc agctggagat 2897641 aatccttgct ttcaagtgat ttttcccaga tccggtcact gatttcactt gttaagtatt 2897701 tcatttgttc aaatgaagga aagtgaaatt caagaacctg cttttgcttt tcagcaagtg 2897761 cctgaagctc tttccgctta ttgtctaagt aaagcttata tacacgctcc cgtttttcct 2897821 cgcgtttttt ccgctggttt ttatcacgga aatattgcac tgtcgaggta atgagagtca 2897881 tcataaacat cgccaaagaa acgagtataa atatgccgcg cggctggatg atggcaacta 2897941 cgcccatcac gatcagcatc acaagcggag gcaggatgac gagccacagc cctctgttgg 2898001 tttgatcgct ctcctgagag ggaaaactga aagaaacgcg gtcatccggc agatcgtata 2898061 ccatccgcgg cgttcttctg tactgcggat attttttctg catctctgta ctcggtttga 2898121 ccgtttctgt taacgctgtt tcaaactggg cataatgaac aatttctaaa aggtcttgtt 2898181 ccgtcaccct catttgcgtg aagttccaga atatttcatc ccccggcttg agcggcgtat 2898241 tggcgttgat tttctctccg ttcaagaaga tcgttccgct ttcagggcgg accgaccagc 2898301 tgccgcctgc acggagcaaa gaaaacgtgc tttgttctgc aaatgcaaaa tcttgcggat 2898361 tcagataaat atctgcattc gttttttctg aggaacatac aatttcatcc cgatttcccg 2898421 taaaataaac ggatttctca ggttcactgc ccgtcaatat caagcgtata tcctgctgat 2898481 ccgtttggag agtaaatgat atatccgtct caatcgtgcc gagacaatca tttcccagga 2898541 aaacttcgta ttggccgccg gattcctttc ttttaagaga aatcactccg ctattaaatg 2898601 gaatggtgct gatcgtaaca gaatccttca catcaggccc tatggtcacc ggatgagacg 2898661 acgggaggtt agacagattt aatttttgaa cgttattttg gtaaaaaacc cataatagac 2898721 tcaaatggcg aaccccctta cggccgaatg gcagcatgcg atgacctgcg cttcatgtct 2898781 cacgttattt gtcatctttt ttctcatctt tcttttctgt ttcttttttc tcgtcttctt 2898841 tttccttctg ttcttctttt ttcgcttttt cctcggctgc ggctttttct tctgccgctt 2898901 tctcttctgc ttgtttttct tcgtctgttt gtgtctgttc ttcgcttgta tcgactaacg 2898961 atgtttcaga attagactgt ttattttctt gacgttcttt ttgggctttt tcaagctcac 2899021 tatttactga atcaagttct ttttgtatgt cttcatcatt tgtatcctca gataaaagct 2899081 gctgtttata tttagctagg gcaaagtaaa tataatcatt gtattccagc ttacggccga 2899141 tactgatcgc ttctttgtat tctcctcgac cataatcaat ccaatataag aaatgctgag 2899201 ggtctgattg aagggtgact aaattatttt ctatattttt ggtttttgca ctccccaggt 2899261 tttcgacctc aacataggac gtcgccagct gatactgcac cgattcaggc aggctttccg 2899321 catcgtactt ggacagtgtg ctgatgactt cactgtactg cttgtttaag aacgcacggt 2899381 tgctgtccac tatcgcctgg tgctttggct gcgcgaaaaa taaggcgtac atcgaataaa 2899441 taagtgccgg tacaagcaaa acaatgagcc ccaggccgat atatcgctgg atgttccact 2899501 tctttctcgg gatatgtatg tatgtttttg ctttggcttc gagctcatca atatgggttt 2899561 gaatcagctc gagcaaatca tcataggatt cagcatctaa tatcgccttt gcctctgcgg 2899621 agaacgtcag cgtttcattg aatttcaggt agtcttcaaa cgcaaaagcg ccgtcaactg 2899681 ccaaagccgc tgccgctttc agctcctgcc atactctttc ctcatcacgc tcgtaaggag 2899741 gaatgctttc ttttactcca taatggagaa aataaggcgt aagcccttta tcgaatacaa 2899801 tgttttcagg agcgacaatc aaattcagcc tcgacagatt gtgctgctgt acggcttgaa 2899861 caagctgata ggcaaactgc catttacttt ttttatcctt agctttcatg aagcggaatg 2899921 ctttatagga ggagggaggt tggattgtga tgattacttc atcatccgtc acatcgattt 2899981 ctttatgaaa aaatggattt atatctttga tcacgttagc ttcaagaccg tcgagaagct 2900041 ttattttttc ccgttgaaag gtaaatgtat agccggcatc tgttttctcg gcaacagctt 2900101 ctaattggtt ttctaaatat gatttttgtt cacctgacat tcaaccagat cctttcataa 2900161 tatttcaagc cggtctccgt ttgtaatgcc gcaatcagac agcttgcatt ctccggaaaa 2900221 caccttatcc ttgttcacca ctctgatcca gtgcccttcg cgcggaggca tagatacgct 2900281 ttgggcctgc caagcaatat caattacttt tttcaccggg tggtaatctg acaatctgag 2900341 atcaaagaca ctgccgttat aatgtttcaa atctattgta atatcaatat acatttagga 2900401 tcacccttac atagaaagag cgccgtcttc ttttgaatca ggcgctcctt ccctttcata 2900461 ctgttatccg cggatttgat ttgcgatgtc ttggtcagta gactcaagtg tatttgctgt 2900521 ttgatcaagc tgctgattca catcttgaag caaatctgac attttgataa atgaaggttt 2900581 gagctgctcg tattgatctg cgaacgcttc gcttgaagca ccttcccaca tgcttttcaa 2900641 atcagagatc attcggttta aacgatcaac ctgatttaat acttcttggc tttcaacgcc 2900701 gtattgcttc gccatcgctc ttagctcttc gggtgtgaca cgaattaatc ctgccatatt 2900761 cctcattacc tcctgtgcca tcagcctaaa tatgggctaa ttcacttatt tttagaacgt 2900821 cattattata aaaacagttt ttcggcatag tcaaacaaat atgttttaat tttacaaaat 2900881 gagtccaatg gtttaccccg aatcactcaa aaatgacata tactgtaaag taaataggtt 2900941 tattttctta atcttctctt cattctccga ataatccaaa agacccaaat aactctccaa 2901001 ctcccaaaaa aaacctttca gaaaatttga tgctacagca ccatttctga aaggttcagt 2901061 tttttctttc cttaattagt cttgcctccg atgactttct tagaagatta ataggataag 2901121 ctgtcgtatt atatgagaca tacactgtcc tgcaaaaagg cgattacacc gccaaatgta 2901181 tatagaacgt ttctctcatg aaattgtttt tttgcttctg ttctttgttg ttgattttca 2901241 caaacaacaa caatcataat aaaaggaagg ggatgagatg tcaaagagaa atcaagcacg 2901301 aaaagtaggg agatttatga ccatgccgaa tgatccgttt aaatatagtt ttgacagact 2901361 tgaagatgtg gctgatcata tcagcgacgt tctgcggtgc ccgatcacca tagaggatgt 2901421 taaccacaag ctgcttgcct acagtacaca cagcgactgc acagaccctg cccggacgtc 2901481 taccattatt ggcagaaggg taccggagaa ggtgattaac aagctgtgga aagacgggac 2901541 aattcctgct ctcttaaaaa cggaccagcc gatcagagtc aagcaaatcg atgaagtcgg 2901601 gctgagcaat cgcgtcgcta tttcgatttg gaaaaacaag caagtacttg gcttcatatg 2901661 ggcgcttgag atccaaaaaa cattgtccga tgaagatctg ctgacattgc aaatggcagc 2901721 aaaagcagtg aaaaacaagc ttctcaaact tcaaatcaga aaaacgaaaa atgaagaacg 2901781 cagccaagaa tttttctgga aaatgctgac cggacacatc catcaggagg atgatatggc 2901841 ggatgggttc cataagcttg gaatggccgc tccttcagag ttttccgtta tgatcatccg 2901901 cataaatggc gagctgactg aaaaaatcga acagcagctg caatatttac aggaaacgac 2901961 ccagcaggtt tacgtgctgc tggcgaccgt agattccaat gaacttatta tattaacctc 2902021 acccaaaaca gatcatcctt ttcaagattt aaaacagttt gctttaagta cgcaaaaaca 2902081 gctgaaggag cggtataaaa tagaagacgt ttctatcgct tttggcggaa tatacaactc 2902141 tatttctttt gtctcccgct cctatcagga agcattgtcc gtcttaaaaa cgaaggaacg 2902201 gttcgctgaa gagaccaaac atcttttcag cttttctgag ttaggcattt atcaatactt 2902261 agatgtctta aatgaaaaac ggaaacaggc gggccattat aattactcgc tttccaaact 2902321 ggaacaatat gaccgggatc accagtcaaa tatggtagag acgctagagc gctttattga 2902381 agcggacagc aacgtgaata ccgcttccaa gctgttaaat atacacgtta atacgttgaa 2902441 ttaccgactc aagcggatca gccagatcgc tgaaattgat ttgaaaaatg tgaatcaaaa 2902501 attcaccatc tatttagata tcaaacttcg gcacatggat ttgtgaaatt tcacaaatcc 2902561 atgttttttt attttcttaa tcaaacaaag aattttccaa aatatcaagc tacactaaaa 2902621 atatcacata tacaggagga gacagatatg atcatagggg ttcctaaaga gataaaaaac 2902681 aatgaaaacc gtgtcgcatt aacacccggg ggcgtttctc agctcatttc aaacggccac 2902741 cgggtgctgg ttgaaacagg cgcgggcctt ggaagcggat ttgaaaatga agcctatgag 2902801 tcagcaggag cggaaatcat tgctgatccg aagcaggtct gggacgccga aatggtcatg 2902861 aaagtaaaag aaccgctgcc ggaagaatat gtttattttc gcaaaggact tgtgctgttt 2902921 acgtaccttc atttagcagc tgagcctgag cttgcacagg ccttgaagga taaaggagta 2902981 actgccatcg catatgaaac ggtcagtgaa ggccggacat tgcctcttct gacgccaatg 2903041 tcagaggttg cgggcagaat ggcagcgcaa atcggcgctc aattcttaga aaagcctaaa 2903101 ggcggaaaag gcattctgct tgccggggtg cctggcgttt cccgcggaaa agtaacaatt 2903161 atcggaggag gcgttgtcgg gacaaacgcg gcgaaaatgg ctgtcggcct cggtgcagat 2903221 gtgacgatca ttgacttaaa cgcagaccgc ttgcgccagc ttgatgacat cttcggccat 2903281 cagattaaaa cgttaatttc taatccggtc aatattgctg atgctgtggc ggaagcggat 2903341 ctcctcattt gcgcggtatt aattccgggt gctaaagctc cgactcttgt cactgaggaa 2903401 atggtaaaac aaatgaaacc cggttcagtt attgttgatg tagcgatcga ccaaggcggc 2903461 atcgtcgaaa ctgtcgacca tatcacaaca catgatcagc caacatatga aaaacacggg 2903521 gttgtgcatt atgctgtagc gaacatgcca ggcgcagtcc ctcgtacatc aacaatcgcc 2903581 ctgactaacg ttactgttcc atacgcgctg caaatcgcga acaaaggggc agtaaaagcg 2903641 ctcgcagaca atacggcact gagagcgggt ttaaacaccg caaacggaca cgtgacctat 2903701 gaagctgtag caagagatct aggctatgag tatgttcctg ccgagaaagc tttacaggat 2903761 gaatcatctg tggcgggtgc ttaattcaca ataagcttgc agaaagattt ctgcaggctt 2903821 ttttattttt taaaaggaaa aaagagacca tttcacgaat tatgactatg aagttgatca 2903881 taaaggagga ttcatatggc tgttcagcaa tatggcgtgt taaaaggcat agtattagac 2903941 atgaagcggg aaacagatga tgacagtcct catttccaag tcaaaatgct cggtgaagag 2904001 aatacgtatt acaggtgcgc catcaatgtg atgtccagtt ctgaggaatc tgaagtattg 2904061 tatttggctg acgatcagtt tgattcgggc tcaattacca tccttccgaa catgccgtat 2904121 ggatatacaa ggatcaatga agcaaaccgt gaagtggcac tggattatgt gcggggcaat 2904181 ttgtttgacc cgcgggaaat gaagcctttg cctcatgaaa tcacgggacc tgataatgat 2904241 ttaaatgatt ttattgaaac ctatatgaag aaagcacaag atgagaaaac gccggtttat 2904301 atattcggtt caaaattcgg ccctgaacag gctgcagata aaatattcgg ctttaccccg 2904361 actaacggaa tgcacaatat ccatatgaat caagggaatg caatggatac ccgctggaaa 2904421 aaagacaacg gctcttggca tgacgggggt attctgattc agtttgcaga tcagtgggcc 2904481 gctgtgtttt tagcgttttt atcccaatct tggtgtaccg atgaaaacgg aaaccctgtc 2904541 agagattgtg atcataccca aacgtctgcg taagatagaa aaagagactg cggcaagcag 2904601 tctctttttg ataagattac acattttcaa cagtctttag gctgtttggc ctcatatcgc 2904661 tccaatgcga ttggatatag tccaaacaag cttcacgccc tttttgctca tgaacgactg 2904721 tccagccgct cggcacatct ataaaacccg gccataggga atattggcct tcttcattga 2904781 ccagcaccaa atatgtgcca tccgcatttt caaaaggatt tgccattcta tttctcctcc 2904841 cttatttatt caactcttcc aatttgacag cgagaacctt gccgatttga gccagaggtt 2904901 caggctgaca taaatcttta tgacggcagt cgatgtcgat ttgttcaatc tgtccgttaa 2904961 tataaggctt ccacgagtca ggttcaatcg ggtcaaacca ttcaggaatg attgttgatc 2905021 tgaaaaacaa aacatttccg cggaaggttt tcggcttata ggaacctaaa atgccgacag 2905081 aatttacata cgtattcttc aaatttaaaa tgaccgtttc atccaggctc gcaagcgcac 2905141 tgccgtcacg gcgaagaatc tcaatcgccg cttcaaaatc tagcggtttt tcccctaagc 2905201 tgtctggatc atacccgcct aacgccagaa gggcaataag cgcttcctca tcatccggtg 2905261 cctcttttat aggaaggaag tggttcggat aggcgtccag catcaccaac agggatactt 2905321 cttctccttg attttgcagc tgggtagcca tcgcttgaac gacattcccg cccagggacc 2905381 agcccagcag atggtacggg ccttttggct ggaccgttcg gatttgttta atgtaatcgg 2905441 cagccatgtc atcaagtgtt ttcggaagct cctcgcgctg cccgattccc cgtgcctgca 2905501 agccgtagat cggataatct gttcctatat tggtcatcaa accggcataa caccagctga 2905561 gcccccctgc cggatgaaca cagaataaag gaggcttgtc tccgcttgtt cggagcggca 2905621 gcagaacgtc aagagcgctt tggcttgatc ccatttcaag tctttcagcg agcccggcta 2905681 cagtaggtgc ttcgaacaag ttgccgatgc tgagttcaac gccgagcgct tcacgaatgc 2905741 ggctcatgag ctgtacagca agcaaggaat gtccgcctaa atcaaagaaa cggtcatcaa 2905801 tgccgacacg cggcaagtga agcacctcca taaagaggtc acagagaatt tcttcctgcg 2905861 gcgttctcgg tcctcgtcct gtcactgccg ctgcgaaatc cggagcgggc agcgctttac 2905921 gatcaagctt tccattcggt gtcagcggca attctttcat cgtcacaaag gcagcaggca 2905981 ccatgtaatc cggcagtctc tcagcagcat atctgcgcag ttccgccgta tcaaatgttt 2906041 cttccgaagg gatgacataa gctgctaacc gtttatctcc cggctgatcc tcacgaacga 2906101 tcactgccgc atcttcaagc tgcggatgct gaacaagcgc ggcttcaatt tctcccaatt 2906161 caatccggaa tccccgaatt ttcacttgat ggtctgcacg gccgacatag tcgagagaac 2906221 cgtcagcgcg gaggcgggcc acatccccag tgcggtacat ccgggtgcct ggaggaccga 2906281 acggatcagc tatgaagcgt tcagatgtta aaccaggccg gcctagataa cctcgtgcta 2906341 accccgctcc tgatacatac agctctccgg caacacccgg cgggaccggc tgcaggcgtt 2906401 catccagcac gtatacacca agatcgggaa tgccgcagcc gatcaagctg tttgcccgta 2906461 aagctgccat gcttcggtct aattcgatat agctcacatg caccgtcgtt tctgtaatac 2906521 catacatatt gataagctgc ggtctatttt cagggtggcg gttgtaccaa tcctctaaac 2906581 ggctgagttc aagcgcttct ccgccaaaaa tgacatagcg cagactgagt gcctgtccga 2906641 gatccggctg ttcccgttcc gcctgcataa actgatagaa agcagacggt gtctggttca 2906701 gaacagtcac cccctctttg acaagcaggc gcagaaacgc ttctggcgat ctgctgacgt 2906761 ggtgaggcac gattacaaga cgtccgccat gcagcagagg accccagatc tcccacaccg 2906821 aaaaatcaaa cgcataggaa tggaacatgg tccagatatc acctgagctg aaacggaacc 2906881 agtgctcggt cgctgcaaat aaacgtgtta cattttggtg aggaatcatc acaccttttg 2906941 gaacacctgt tgagccggat gtataaatga catatgccgt attcaaaggg gaaagcggct 2907001 gagtcctatc cttatttttt ggattacctg cagggtacgt gtttagtttc tctgccagct 2907061 cgggatcatc cagcacgatt ttcggcacgt tttcaactgg cggaatgtga tttgcagctt 2907121 tagtgttcgt catgataaac gcaggctgtg catcttttag cataaaagca attcgatcag 2907181 ccggataatc cggatcaaga gggagataag ctgccccggc ctttagcacc gccaataggc 2907241 cgacagccat ttccaacgat cggggcagtg ccaatgccac aaattgctcc ggcccgacac 2907301 cttcactaat catcattcgg gcaagccggt ttgctctttc attcagctct gcatagctca 2907361 gttcctgatt ttcatataca acggcaatgg catcaggacg taaagcagcc tgcttctcaa 2907421 attgctctgg caaacatgcg tgcggaatct tttcagatac actttgccaa tcagtcacca 2907481 tgctgctgtg ttcctctggc gcaagaatat ccagatttcc gatttgctcg tcaggatcag 2907541 actcggcagc ctccaacagg cgcatcaatc ggtcagcaag agcctgagca gtttcccgtt 2907601 tgaaaagatc agtgctgtat tcaagcagtc cttccattcc gtttggtgtc ccgtcagcaa 2907661 ggcgatcttc actaatttcc agcgtcaaat caaacttggc agaaccgaca ctgttgattc 2907721 gcaggctgct ctccatatca ggaagatgca gttcagcgtc cggtgtgttt tggaacgcaa 2907781 gcatgatttg gaataaagga tgcgtcgcac gcgaacgagc cggattgagc acctctacaa 2907841 gtctctcaaa cggcagatcc tgattgtcat aggcggccag attcacttcc cgtactctgt 2907901 ctagaagctc acgaaagctt gggtcaccgg acgtatcagt tctgagcacc aatgtattaa 2907961 tgaacagccc tacaagatcg cccagcgcat catcattccg tcccgcgatc ggactgccga 2908021 tcggaatgtc ggtgcccgcc ccgagccttg tcaataaagc ggcgagaccg gattgaagca 2908081 ccataaacag gctcacccta tttgcgcgag ccagctcctg caatcgcttg tgaaactcgg 2908141 gctcaatacg aaaatgaatc gtatctccat catgactcgg ctcagccgga cgtgaataat 2908201 cggttggcag ttcaagctga tcaggcaggt ttttcaaggt ttctttccag aaagcaagct 2908261 gtccggcaat caagctattt ggatcatcct cgtttccaag cagttcttgc tgccaaagcg 2908321 catagtctgc atactgcaca gcaagaggcg cccattcggg agatcgtccg tggcagcgag 2908381 ccgcataagc tgtcccaagg tctctggtca gcggtgttaa ggaccagccg tccccgacaa 2908441 tatgatggac gagaagaagc agcacgtact cgtcaggacc gatcacaaaa agctcggcac 2908501 gaaaagcagg ttcagctgca agatcaaagc tgtagcgtac agcttcggca agccgatcag 2908561 aaagctcctt ctcagcaatt tcagtaacat gtaactcggg acaggctcga tcggcatcta 2908621 aaatatgctg ataggatgtc ccctgtgatt cagggaagat cgtccgaaga ctttcatgac 2908681 ggcagacgag gtcataaagt gccgctttca gcaatccttg atccaactca cctgacaaac 2908741 ggacagcaac cggaatatta taagtaggac tcggtccttc cagacaatgc aggaaccata 2908801 gccggcgctg ggcaaatgag agcgggatct tttcaggccg ctcagctctc tgcaaagcgg 2908861 gacatgcact ctgcgccaaa tcaagatggg cagcgagtcc ggctactgtc ggttcgtcaa 2908921 agagcttggc gataccaagt tcggctccca ttacctcgcg aatgcggctc atcagacggg 2908981 ctgcaagaag agaatggccc ccaagctcga agaaactgtc atcgataccg acgcgtgcca 2909041 aaccgagaac ctctgcaaac aagtcacaca atatctcttc ctgaggagtc cgcggggccc 2909101 gatcactgac agatgtgctg aagtctggtg ccggcagtgc tttccggtca agcttgccat 2909161 taggtgttaa cggcagctcg tccatctcca caaacgccga cggtaccata taatcaggaa 2909221 gactagcccc catataacga cgaagctctg cagtatcaat agcagcatca gcgactacat 2909281 aagccgccaa tcgtttgtct cccggctgat cttcccgtac gacaaccgcg gcctgttcaa 2909341 tgtgcgggtg attggcaagc acggcatcaa tttctccaag ttcaattcgg aatccgcgaa 2909401 ttttgatttg atgatccgcc cgcccgatat aatccaaaga cccatcggcg cgccagcggg 2909461 cctggtctcc ggtccgatac atccgagttc ccggcggtcc gtatggatct gcaacgaagc 2909521 gctccgccgt taaatcagga cgatggaaat aacctctggc caagccggtt cctgcaatat 2909581 aaagctctcc gacaacgccc ggcggcaccg gctgcaatcc attatcaagc acatacacct 2909641 gcgtgttcca aatcggtttc ccaatcggag gaacgccctt cagcccttct tcaagaaaag 2909701 ctgcggcaga ccaaatcgtt gtttcagtgg gaccgtataa gttcgtgact gaacaatgaa 2909761 ggtcttgaag ttcctgcaaa agaccgctcg gcagcgcctc gcctcctaca agcactctaa 2909821 gcccccgaag tttctcaggt tcactcgtta ccaaagcgtg ccacagtgtc ggtgtcgcct 2909881 gcataatgtt aatatcgaaa ttttcaatca tttgagctaa tgcctgcggc tcacggatcg 2909941 tttctttctt tgcgatcacg atttgcgctc cgctaatcag cggaagatat aactccaatg 2910001 ctgaaatatc aaaagcgaca gtcgtcacag ccaacagcct gtcttcttct cctagagaaa 2910061 atgcctcctg catagacagc agaaaattgc ttaagctttt ctgtgtcaca acgactccct 2910121 tcggtcttcc tgttgatcct gaggtataga tgatatacgc aggatggtca agcgaaaccg 2910181 atacatcctg attttccggc gaatagcgtt ttataatctc ctgtgtaaca gcctgatcaa 2910241 gcacaagctc aggtacagcc aggtcatcag gcagactggc tgctatttcc tcagtcgtta 2910301 tgatgcatga aggtttcgca tcctccagca tgtaagaaat gcggtcggct ggaaactccg 2910361 gatcaagggg gagatacgcc gcaccagtct tgagcacacc aagcattgaa gccaccatct 2910421 caggggaacg cggcagcgcc aaagcgacaa attgctccgg accaatccct ttttcgatca 2910481 acagacgcgc gaggcggttt gcctcttcat tgagctttcg atagttgact tgaatgtcat 2910541 cacacatgag agcgatacgt tctggcgtaa gaactgcctg cttttcgaac atgtcctgaa 2910601 ggctgaccag cttctcggat tttgccgtct cattccattt agaaatgact ttttctttct 2910661 cctctggcaa cagaagctcc atttgcccaa tcagcatgtc ctctccggca gaagccgttt 2910721 gcagcagctg caaaatacgc tgctgatgaa gcttaatatc agactcactg tatacctcgg 2910781 gattcgcatc aacatcaatt cgcagcccgc tgccgtctgt tctgtcatat acattgattg 2910841 atagatcatc aacaggaccg gctgaaagat tatgcgttgt gccccggacg ccggcaaagt 2910901 cgagaccgta atcaaacggc ataagattga tttgagggcc aaataatcta tgattttctc 2910961 ctatcaattt cagatcgcgc ctaagctctt catggcgata cttatgatgt cgccgaatac 2911021 tgcggatttc ccgggaaatt tgctgaatca gttcagaaaa gctcatcgaa gagcttaccg 2911081 tcagccggag cgggagaagg ttcatcacca tagccggtac attcagtgac gcggacccta 2911141 tccgacccat catgggcagg ccgagcacaa catcctcaga gccggtcata cggtgcacat 2911201 aaacagctga caccgcaatc atgacttcat gccagcttcc tgagaaatag cgcgccgctt 2911261 cttttaacgc gtttacatca gacggaggca gatatgccgt atgacgaaga aaactgttag 2911321 atgttcttgg cgcccgatca gccaagctca caacttcagg tgcatctgca aaacggtcca 2911381 gccagaattg acgatccttc tcatactgct ctgatccgcg ataatctgta tcctcctcca 2911441 aaatggcctg gagagaccca aaggaacggc ttttagctgt ttgtcctttt ataagggcag 2911501 tatatgtact tgccacacgc tgggctatca gggaaaaacc gaagccgtcg atcgctatat 2911561 ggtgaatgcg ctgataccaa aagaaacgat caggcccggc aataaacaga gcttcattga 2911621 acaaaggggc ataccctaaa tcaaccggct ttgctaaatc agctttcatc cagtttaatg 2911681 ctgttttttc cggatcaggc tcagagctga cgtcaatgac gtgcagctgt acatccggag 2911741 acgggtttat catctgccaa ggcccgtcca tattttcacc gaagcggaca tgcagcgatt 2911801 ccgcttcctt gatcacgtgc cgcaaagctt cttcaaaaag agcaatattg actggtccat 2911861 tgatttctat atattccgct gtattgtaga ttggattgtc cggatcaagc tgctgagcaa 2911921 accatatgcc agtttgcgcc ccggtcaaag aatattgaag atcttttgta tcaggcatcc 2911981 gtttgtttac cctcctttta taaataatcc gcgtttggca gcacttgctg gctgcgagtt 2912041 gtgagcaatt tctgccattc ttcgatcgtt gggcgttcag ccaattccac gaaagtcacc 2912101 tctgcccctt cacggcgcca ttgttccacc aatgtcatga tccttaccga atcaagacca 2912161 cgatcgagca aatcctcttg atctgtgatg tcttccggtg tttcttgtag aagctcagca 2912221 atttgtttac ggatattctc acatgtaaac acgttctttt tgccagtgtt tgctgacgtt 2912281 ttttgaacgt ctgccggcgc attctgcagc tgatcaagaa gactgtcagt catcacggta 2912341 aacgcacagc gtccagccgc atattccagc gccatttgat gtttttctaa tgaaaaatca 2912401 gcaactgcat ctcccacaaa aaaggcttta atatcctcca taaatgcttc acatgctgta 2912461 acaagacagc cgatatgggc gtaaattcct gtaatgatca gctgatcgcg tccctctttg 2912521 cgcatcattt caagcagatt cgttctctta aacgcgctgt atctccattt tgtcagcaca 2912581 agatcatcat cctctggtgc cagctcggtt ataattttct cctcataagg accgctgttt 2912641 aatcccgggc cccaaaagtc tgtcagcagc gcacggtcat ccggattttg gcttcccggc 2912701 tgtgcggtat agacaacagg aatcccaagc tgaacacatt gattcttcag ctttcgtata 2912761 ttcgctgaaa gctctgttac cggagacgct cccgctgtga aagcatcaac aaaatagttt 2912821 tgcatatcgt gtattaacaa gacagcccga ttcggatcag gcacccatga tactttgttt 2912881 tgcggcatat cagatgctgt cggcatttga tacggctgaa tggcaggtat agccatatga 2912941 acacttcctc tcaaattgtt gttttatttt ttaaatcctg caagaagctt ctcggaaatg 2913001 gcttcacgga gcgctttttt gctgactttt cctactcctg tctgcgggaa ggattcgaca 2913061 aattcaactc gatcagggat tttatatgcc gccagtccgc gctctctcaa aaatgcttta 2913121 agctctgcgg cttttggggc ttcatcccgg ggaataatga acacacaaga tctttcgcca 2913181 agaaattgat caggcatgga gaccattgcc gcatcatgga cagccggatg cgccagcaga 2913241 tgattttcta cctcttcagc cgcaaccttt tctcctccac ggttaatttg atccttcgcc 2913301 cggccttcaa cgacaatata gccgtctcgt gtcagcctga cgatatcacc cgtacggtaa 2913361 aaaccgtcct cagtaaatga agcggcgtta tgctcttctg ccttatagta acctcgaatt 2913421 gtatacggcc cccgcgtcag cagatggcct gtttcaccag gttttacgtc gcgatcatga 2913481 tcatcccaaa cacgcatttc atcatatgga gacatcggtt ttccttgggt gttgacaatg 2913541 atctcctcag gatcatccaa tctcgtataa ttgacgagac cctctgccat tccgaacacc 2913601 tgctgcagcg tgcagccgaa aacagctttt accctgcgcg cggcttcagc actaaacttg 2913661 gcaccgccga cctgcagcac ttgaaggctg gataaatcat cacggcgtga ggatgccgca 2913721 tccatccata ccatcgcaag aggcggaaca agagcggtta tcgtgacctt ttcccgttca 2913781 attaaaggaa atgcgtcatc tggacttgga gaaggagata ataccactct tcctccagcg 2913841 tataatacgc cgagaacgcc gggtgagctc agcggataat tgtgtgccat cggcagcgcg 2913901 gccaagtaca ccgtgctgtg gtcgagccag cagacctcca cactccgctt caggctgtat 2913961 atgtagtcat cgtgggtcct cggaatcagt ttcgatagcc cggtgctccc gccagaaagc 2914021 tggaggaacg ccacatccga tgatttgact tcaggcagtt ttacaggttc tgcatgcaaa 2914081 tcctccagcg gtaaaaattc ctctgcctca cctgcgacaa tgatgttttt caaagtcggc 2914141 agcttgcttt gaacctgtct ggcaagcgaa cggtagtcaa aaccggaata agcgtcggga 2914201 atgatatatg cagccgcttc agcaaactcg caaaaatatg taatttcact gcttcgatga 2914261 gaaggcagtg cgaagactgg aagcgccccc agacggaaaa gcgcgaaaat gacttcaaaa 2914321 aactctttga tatttggcaa ctgcaccaca acacgatcca tctgttgaat gccgagcttt 2914381 tgaaatccgg cagccaggcg atcagccctt gtgtcaagct ctcgatagct ccaatgggtg 2914441 tttccgcatg taatggcaat gcgatcacca tatttggctg cccggtccct taacaaatct 2914501 ccaaacgtct caccggccca gcagccgttc tttcgatagg tctcagctaa ctcatcaggc 2914561 caaggcgtaa atcctttcag catgttgtat ccctccagca attcattctg ttcatatgtg 2914621 atccacgccc attgcccgca gcattgtccg aaactttgcg gacgtctcct gaagctcgtc 2914681 ctcaggcttt gaaccggcca caacaccagc tccagcatac aggcggagtg agcgttcttc 2914741 tgcttctgca caacggatgg tcacgatcca ttctccgtca ccggcatcgt cacaccatcc 2914801 gaccatgccg gtaaagaaac cgcggtcaaa tggttcaatg ctgagaatcg cttctcttgc 2914861 aagatcagtc ggtgttccgc agacggctgg cgtcgggtgg agcgccgccg ccaattcaag 2914921 tgcggttaca gacgggtcgg aaagctctcc cttaatcacg ctggacaggt gccacatcgt 2914981 ttccgttttg atcagtgaag gcttctccgg aacctccagc gtccggcaga aaggtctcag 2915041 cgctgccgca accgcgtcag cgacaaccgc gtgctcatga agatcctttg cggaagaaag 2915101 caattcagct gcccggcgct ggtcttcaac aggatcatta ctgcgcggtc ttgagccggc 2915161 taatgggttg gaaacgacct gtgttcccat ccttgaaacg agaagctccg gacttgctcc 2915221 gagcaatgtt ctgcggggag acgtttcctc ctgactggac acgtctgcgg caaacgtgta 2915281 gccatgcgag ttatgctgag ccagatggcg aagcaattca tccgtctgaa tcggttcagg 2915341 cgatgtcaaa tgcagcgatc tggacaggac gattttgctg agtgttccat cggcaatgcg 2915401 tgccagccct tgttcaacac catttttata atcctcaggt tcaggaacag gctttatgtg 2915461 gtatgtatgc ccagcctgct gttccttttc ctcatgatca aattgaagcg gtcctgacca 2915521 gcgcacttct tcaggtacaa cgagccgcgc tgcttttact tgatcaaaag gaacggcccc 2915581 gacaacaagc ggccggcttt gccctgattg ttttgcctga cgtaacgcct ctgcaattcg 2915641 gccagaaagg gtttccattt ggttttgccc gtctgcctcc ggtacaattt cacatatgcc 2915701 tttcgctaac agtacacgat gaggagacgc taagaaaaag gcgcccggct gatattcatg 2915761 aagcaaatgc tccgcttttg tttctgttat aacgttttga tccaacattc tcatgaacct 2915821 cctttaaatt cagttacacg cctaaggtcg cgccgccatc tacgcataaa ttatgcatcg 2915881 taatatgccc tgcctggcca gaaaccaaaa agagcaccgc atccgcaata tccgaaggct 2915941 tggctagttt tttgagcggg atccctgttt taaatgtctc aagtgatcct tttatgactt 2916001 gctccgctcc attctcgtcg gcccataatg accactgcat gtctgtttcc gttgatccgg 2916061 gagatacaat gttgcagcga atattgtatt ctgcaagctc aaggccaagg catttcgtaa 2916121 acatcacagc cgcagccttt gaagacgcat atgccgccat agatgttctt ggtacaccgg 2916181 cagcattcga tccgactgtt acaatcgaac ccgatcttcg gtccatcata tatttgctga 2916241 ctgaacgcga ggcgttaaat acgccagtcg aattcactga gaacgtcgcc tcccattcct 2916301 catcgctaag cgaatggatc agtcccgggc gaaggacacc cgctacattc actaaaatat 2916361 caatcggccc catttcacgt tcgatgcgcg ccgtgatctc gtcaatcgcc gcgctgtctc 2916421 tcacatccgc aggaaaagct tctgcatggc ggccttctgc tttgaggctg ctcacaacct 2916481 tttccagctt ttcaggatta taatcaactg ccgcaatatg tgcgccttga ctggcaagcg 2916541 tccgcgcaac agcttcgcct attccttggg cagcccctgt tataaaagca atttttccct 2916601 ctataccctt tgcattcata tcatcaattc ctttcttcgc tctaaatgcc aaacagacat 2916661 ccagcgaaaa agactgctgc gccttgaaaa acgcaatcta ttgataatga ttatcattat 2916721 caattataaa aataatcata tccaaatgtc atgtgacagt caaatataat ttcagtgaca 2916781 aatatttttt taaaggcaag gctgagtatg tctcagccca ttgatagatg cggtccgtca 2916841 gggtgaagcg caaaacgcag cgccctgctg accaaaacag gaagaactga aatatgtcct 2916901 tctcctgaaa actcgcaaaa ttctgcccgt ataccttgtt cagataaaac ggccagccgc 2916961 tcataaagct cccttgcatt atcattcatc cggcttttat gatgctgctc taattctcct 2917021 gcggcaagca ggatattgat aggctgattg tttttcttgg tgagagagac gaaatggtcc 2917081 gttttcttga gaataaacgg tttattccaa tgaatggacg gacttcccgc gatatacgtt 2917141 tgaaacgcat cgggctttgt tagcagcacc tgcagcacga aaagccctcc gagcgaatgg 2917201 ccaaagattg tttgtctttt tttatcaatc tggtaatctc gttctatctc cggttttaaa 2917261 tcctcttcaa taaatctgaa aaagccctcc gctccgccat gctccggcca ttctctgccg 2917321 tcgggccttt ccggcagctt cgattgggct gttggcattg taaaatcccg gtggcgtgct 2917381 gaggagaacg gctccgctgt ctcatagcca atgccgacga tcactgcagg gatcaccccg 2917441 gttttttcgg gtcggcgtcc ctgtattcga acggcttccg tcatcgttcc gaagacagaa 2917501 ttggcatcca gcagataaat cacaggataa ccagcgggtg gcggcggcgt actaggtttc 2917561 gagataaaaa tgtgataggt acggttttca ttgcgtgaag acatcatacg cacttccgta 2917621 ccaggaatcg taaatgcgtt tgatgtcccg ccatttgtcc ggtctgttgt ttgttctttc 2917681 atgcagtacg acattcctct ccttaaacta aaccgcaatg tatgataatg attttcacta 2917741 tcaactagac acctcaaata ataggttttc ttccaaagaa agtcaacttt ttcccgaata 2917801 aaaaaggcac cttgatcaaa taaggtacct gcagactatc aatatggaag taaaaaccta 2917861 ataaagatgc gtattgtcct atttgaaata gaaccttaat cccatgtaaa cctttgattt 2917921 tgccaagggt cgcctctcat gtgatagcca ttccgctccc aaaagccagg gtgattttct 2917981 ttcgtaaatt ggatgccgcg cagccacttg gcgcttttcc aaaaatacag atgcggaaat 2918041 acaccccgca gcggaaagcc gtgttcaggg gttaaaggtt cgccattatg cgcataagcc 2918101 agaagggaag tttccgctaa gaaatcatca agcggcagat tggtcgtcca gccctcttca 2918161 gcatgtaaaa tgacgtagcc cgcttcttct tttacacccg ctttttccgc tatatcacaa 2918221 gcccgcacgc cttgccacac attatcaagc cttgaccatc ccgtgacgca atgaatgtcg 2918281 tttttcgatt cataccgtgg aaaggctttg acatcttcaa agcttagcag catcggatgg 2918341 tcaaccaaac cgtatacttg aagattccat ttcgtcatat cttcgtaata tgggacatct 2918401 ccggtatgaa gcacaggaaa tgaagtggtg acgttttgat ttggcggcac tcttccagat 2918461 tgatcggact gtcttgtttt tccgaaatac atatgggcct cctttttgtt aacctaattt 2918521 aaaatcatgt tgacaatctt tttgttcttt attactctat gattgtgtat gtcaacctaa 2918581 gggggaacaa cgatgaaaca acgtaaactt cgtgcgggag atatggcgct gattggcatg 2918641 ttcgccgcac ttatggctgt cggggccaac attacatcag tagcaccctt tttacaagta 2918701 gccggcattc cgctttcgat gcagccgttt ttctgtctct tggcagcttt gcttcttggc 2918761 agcaaacggg cagcgattgc catgattgta tatgcacttg tgggattggc cggagcgcct 2918821 gtgtttgctc aattttcagc aggcttcgca ccgtttgcag ggaaaagcgg cgggtttatt 2918881 atctcataca ttccggcagc atttgcagcg ggatggtttt tagaacgaaa cattcagcca 2918941 agtaaaattc gatttctcat tgcttcactt atcggaacgg cgatcatgta tctcatcggc 2919001 actacctata tgtatcttgc actgaagctg tggattcata cgccagtgag ctacggcacg 2919061 gcttggggct ttatgatttg gtttatggta aaagatacag cgctggctgt gatactgtcg 2919121 tttatcgcac cagcaatcta ccgctctatt cataaagcaa ccggctttaa cagaaatcac 2919181 atatcatcta cgtaaaaacc gttctattgg acggtttttt tatcataacg agaaaaggct 2919241 ccccagtaaa ggggagcctt tttcctataa aacaagcgct gcaatccagc caaagatgac 2919301 aagcggaata ttataaaata taaatgtcgg cacacaagta tcccaaatgt ggtgatgctg 2919361 gccgtccgca ctcaaacctg aagtcggccc aagcgtactg tcactggcag gtgaaccggc 2919421 atcgccaagc gcagcagcag ccccgataat cgcaatcgtt gccatcgggc tgaatccaag 2919481 ctgcatgcat agaggcacga aaatggttgt gataacagga atggtcgcaa aagaagatcc 2919541 gatccccatt gtaattaata agccgacaat gagcatcagc aatgcgccca aggactgact 2919601 gtgtccgata aaaccagctg acgttttgac cagtgactcg acatctccgg ttttcgtcaa 2919661 tacgtttgaa aatccggctg caacaagcat gacaaagccg ataaaggcca ttaaaaccat 2919721 tccatcagta atcagtgagt ccgcttcatc acgcttcatc acaccgctga caaacagaac 2919781 aatcagacca gcgagcgccc ccataatcat tccttctact cccaaagtct gagataagta 2919841 aagctggacg ccgagtgaca caacaatggc tagaaccgcg ataccaatac tttttctcgt 2919901 atatggcgat gcttctgcac ctgaaatgtc ttttgtttca tattgtttcg gtttacggta 2919961 tacgatcact gataaaataa ggccgacaac catacctgca actggaataa tcagtgcgta 2920021 cggaatatca gcaagcggaa cgtttaaccc ggcatccgcc atattgtcct tcagcatgcc 2920081 ttggaagatt tggccgaaac cgaccggaag caaaatataa ggagccgtta agccaaatgt 2920141 aattacacac gcgatcagac ggcggtccat ttcaagttca ttaaagattt tcaaaagcgg 2920201 cggaatcagc accgggataa acgcgatgtg aaccggaacg acgttttgcg aaaaacaaga 2920261 tacaattaaa ataatcagca caatcagcac cttagacagt gctttttttc gagaatcttc 2920321 tttatttccg attaatttaa cggaggcttc caccattgcg tccggaagac ccgttttcgt 2920381 caaagcggcg gcaaacgcgc caagcatggc atagctaact gcaacggtgg catttccgcc 2920441 gagaccgtct gtgaaagctt taaccgtttc gccaagaccg agcccgcctg ttaacccgcc 2920501 ggccaaggcg cctataatta atgcgataac aatattgaca cgcagcaggc ttaatacaag 2920561 cataagcagg actgcgatga cgactgcatt catgatgata cccctccaaa aatcctttag 2920621 tttgctaatg tagtagataa ataaagtacg aacgtatcgt atcataaccg atccacttta 2920681 gtcaactaaa gatttcggaa gaaaaaatcc ctgccgcatc atacagcagg gatttttcat 2920741 tactcgtttt tatcttcttc caatgtaaat cgctccgcaa gtgtagccag tgttcttgcc 2920801 ataacgccag tagccccggc cggtccgaag caggttgctt tattggcagt cgctgtgcct 2920861 gcaatatcaa ggtgaaccca aggtgttgac tcagcgaatt caccaagaaa cgttcctgcc 2920921 ataatcgcat gtccctcgcg tcccggtgaa ttgctgagat ccgccatttg gctgcttttc 2920981 acgcgttttt tatccttctc tgttatcggc agctgccaga tcgcctcgcc gcactcttgt 2921041 gcagcatcag ctacctgctg gtaaaagctt tgatcatttg tcattgcacc ggttgtttct 2921101 gttcctaatg ccacaacgac gccgccggta agcgtagcta catcgacaag aactgatgcg 2921161 ccatgctgtt tcgcgtatgt aatgccatct gcaagcacta gccttccttc agcatccgta 2921221 ttaaggattt ctattgtttt tccgcttaaa gatacgatca cgtcatccgg cttcatggcc 2921281 ccgccggaga tcatattatc ggttgatgga ataacgcaca gcacgttttg ttcaggacga 2921341 agctctccga tcgtttccat agccccgaga accgcagctg ctcctcccat atctgatttc 2921401 atgccaacaa ttccagattt cgttttaatg gagtagccgc ctgtgtcaaa ggtaattcct 2921461 ttcccgacta gtccgacgac gtcttcccat tcctttttgc cctgatattt caacacaatc 2921521 attttcggcg gttcggtgga gccttggttt accgcaagta ttccgcccat accgagctct 2921581 tccatctctg atttctccaa tatctcacac tcaaaatcat atttcgccgc aagctcttca 2921641 gcatacgaag cgaggtcagt cgctgtcagc atgtttcccg gcatattcac aagcgttcta 2921701 gccgaatttg tcccttgtcc gtatgcctgg ccgacgcgaa gccctgcctg cacttcctgt 2921761 gtatcttcat ctgttacaac atacacggct tcaatttgtt tgtcaggctc atttgattta 2921821 tgcttataat cctgcacctc ataggaagca agcaggcagc tctcagctaa agcatgagcg 2921881 gcatcggctg gaggcacgtc ttccgaaata aacgtatcaa gcagaacagc agtttcttgt 2921941 tttcgatctt tatgaatggc ttgaaaaaca tgagcaaaac gttccttcgc ctgttcaaac 2922001 gaataatttg cttctctccc caggccaacg aaataaatcc gtttcatacc cgcagaagat 2922061 ggagggaata cttttgatac ttgattcggt ttcgcagaga catcaccctc ttttaaaagc 2922121 tgtgtcagat ggccttcgag catttcatca atttccaacg cttttcctgt cagctggctt 2922181 ttttgaaaaa gcccgacaac aagggtttct gtatgctctg attgttgaac cgcataaaac 2922241 atgaggctta cactcctaac gtaatgggta tttgtaatga acaatggtat aataggaaaa 2922301 acattctttc cactatactt attttaacaa acaacagtct aagacttgct tttttctttt 2922361 gaaacacgaa ggatttttca aatagaaagg atgtcgccga tggaactttt aacgaatttt 2922421 cctttattat caagcctggc cgcaattatt tttgctcagg tcatcaaagt gcccatacag 2922481 tttatcgtgt ccagaaaact ggactggtcg ctggtcacaa gcacaggcgg catgcctagc 2922541 tctcactccg cagcggtcac tgcgctttct acaggcgtag ccttggagca tggattagac 2922601 tcctcactct ttgcggtttc cgccattttc gccgtcataa ccatgtttga cgcaactggc 2922661 gtcagacgtc acgccggtga gcaggcaaca gtcattaata agcttgttat tgattttaac 2922721 cgtttcgtaa atgaagcgaa ggacttccct aaggctgcag agaaagaaaa gcaaaaaaag 2922781 ctgaaagagc ttctcggaca tcagccgatc gaagtctttt tcggaggatt aacaggtatt 2922841 ttactgacat tggtactcgc ttactttttc atgtaaaaaa aacgctcctg ctttcgctgg 2922901 agcgttttat tctttcaccg ttttatattg atttctgaac acttgcaaag attttgtttc 2922961 attgagcttc tcaagctcat cctcggtaat ctttcccgtt ccctttttaa tcacatatac 2923021 atcaagggtt tttttgcccc attcattgta tacatctttg actgtctcaa agtacagatc 2923081 aaggcggttt cccttaatag ctgatcctgt gtcggccaca actccgagac cgtagttcgg 2923141 aatgaataaa attgttccga tcgggaaaac ggacgggtca gcagcaaccg tggaatataa 2923201 atcccgtttc actttcacac ctgaatatgt aagcccgtat aatggatcac cgggattttt 2923261 gcccgtcgac tcagctcctg ctgtgtagcc tgttgctgtt actctttgga ctggatattc 2923321 atcccaatca aatgcctctt ctaacggttt tgttttatcc tcagccgcgg acgtggtttg 2923381 tgtttgtttc tgctgcaatg cttttaatct cagtcctgca tgcttcaagt gcttttcctg 2923441 atgttcctgc acccattttg acaagtcctt cgcttcaatt cctgacactg ataaaaatgt 2923501 cgtgccaaat gcaagcagaa ataaacaggt catcagcaaa cgtctgatca tattcaacat 2923561 cattcacctc tcctccgaat cattgttccc aagtggagag agcattattc aaaatggtga 2923621 atgagctgaa cgcataaaaa aagctttctt tagaagaaag cggcatttaa aacatttgat 2923681 atcctctttt tctaagcatg ttgatcgcta taccggacac gatggcgccg gccaaaccgc 2923741 tgactaaaat cagcacatca gcagccgcta atgataagac acgatgaaac aggctggcaa 2923801 aggattctcc cggcgactgg acatagctga tcagcttttc tttgctgata atgaaaaggc 2923861 atacaattgg ataaatcaca gccataatcc aagacattct cagcagcatg tttaataaga 2923921 aaccgattcc aaaaaacaag acaaaaaaca aaacaattga gatgattacg actggcagac 2923981 taatcaacct attccacccc cctgcgttgt ttttagtgta acgcgggggc tgaaataaag 2924041 tcaacggctg gaaaaagaat gactgtcttt tcctgtcccc tggcaagacg gacaagtctc 2924101 tgaaccgccg agaatcaatt gaaaatatcc tttccctgaa caaaatgggc atgcatgtga 2924161 agcggttgtc gttgcagttt tcatctaatc atcacccttt ttcttaattt tctgataata 2924221 taccatatca agctgtcaac aataaagtca gatcatgtga caaatctttt gatgtaagcg 2924281 gaaacatact tgttttcctc tcgttctctt tttattttgg cgttttttaa taaagaaaac 2924341 ccgcttccgc gggtttttag aaaaacttga acttgccttt tttcaatgtc agtccgagtc 2924401 cgccaatcat aaacagtgag cggttatcaa tgactttttt cataaacgaa gcgggcgtgc 2924461 ctttcagctt tctgccataa acaaccccaa ccgcgttatg ctcgccaaga gaagccactg 2924521 ttcccttaat gtccggcttg aattcctcaa gctctccgcc tttaataagc ctgccaaggt 2924581 ttttagcgac cgttatgccc tgctgcattg caatttgcgc agtcggcgga tacgggcgct 2924641 ctgtatcttc attcataaac agcgagctgt cgccgagaat aaagacattg tcatgtcccg 2924701 gggcgcggag atcagggttg actttgactc ggccgcgcat attctcaaaa ccggcttcct 2924761 ccacaatcgg atggccgcgg acacctgccg cccatacaac ggtttgcgat ttgatctgct 2924821 ctggttcttc atcttttttg ccgactctga ctccttctgg tgtacattct tgtacagccg 2924881 ttccgatctt gaactcaact ccgttttcct caagataatg tacggcgtaa tcaacaagtt 2924941 ccggatcaaa gcccggcaaa acggtcggcg ctgcttccac acaaatgatg cggacaaggc 2925001 ttctgtcaac gtcatattcc ttacagagct ccggcacgcg agcagccagt tcgccaagaa 2925061 attcaattcc cgtaaatccg gcaccgccaa caacgatcgt taacctgtcc ggccgttttt 2925121 ccgcttccgt attgtaagtc gcaaactgca gctcaatatg ttcccgcagc aggcgcgacg 2925181 tgttgatgtt ggcaatcgga aacgcatatt cttttaagcc tttaatgccg aacgtttcag 2925241 gcacggcgcc gagcccgatg actaaataat cgtactgcaa ttctccattc gcaagcacaa 2925301 cttttttctc atcaattttg attgccttta cggtatcctg tacaaaattc acccgtgact 2925361 ggttgattac atcttttatc tgataacggc agcggtcatg atggagcgta cccgcgctcg 2925421 cttcatgcat ccatgtcgtt tcataatgat aattgtgttt atttacaagc gtaatgtcag 2925481 catcattcgg cccgacatac ttcgtcagcc ttgtcaccgt catcaatccg ccatatcctg 2925541 cacctaaaat cacgattttg ggcttattca atgccatcac atccaccttc tctttttttg 2925601 cttttgttag acccataata aaatcatcat ttgtgttagc ttcagcttat tggcgggatt 2925661 ttatgaaata tattgaaaag ttttttgtga agtccttacc cgtagcacta ttatcatgtt 2925721 tatccggctg gcccaagaaa cattcagaaa aagatcattt catttggtta ttatcgtagc 2925781 ggcctgcgga aatattttca agaacggatg ggcacgttag atccttacga ttttttctgc 2925841 tgactcgtca atttgaacgg caatatggta taattaataa caattttcat ttaggaggca 2925901 attttcgtat gcgagaggat acaaaggttt atgatattac aattataggc gggggaccgg 2925961 tcggcttatt caccgctttt tacggcggga tgagacaggc aagcgtcaaa attatcgaaa 2926021 gcctgcctca gctcggcgga cagcttagcg ccctataccc tgagaagtat atatatgatg 2926081 tagcgggatt cccgaaaatc cgcgcgcaag agcttatcaa taacctaaaa gagcaaatgg 2926141 cgaaattcga ccaaaccatt tgtctggagc aagcggttga atctgttgag aaacaagcgg 2926201 acggcgtgtt taagcttgta acaaatgaag aaacccacta ctctaaaacg gtcatcataa 2926261 ctgcaggaaa cggcgcattc aaaccgagaa agctggaact tgaaaatgcc gagcagtatg 2926321 aaggcaaaaa cctccattac ttcgttgatg atctgcaaaa attcgccggc agacgcgttg 2926381 cgatccttgg cggtggagat tccgcggttg actgggcgct tatgcttgag ccaatcgcaa 2926441 aagaagtatc gatcattcac cgccgcgaca agttccgagc gcacgagcac agtgtggaaa 2926501 accttcatgc gtcgaaggtt aatgtcctga caccattcgt ccctgcggag ctgatcggcg 2926561 aagacaaaat cgaacagcta gtgcttgaag aagtgaaagg cgaccgcaaa gagattttag 2926621 aaattgatga cttaatcgtc aactacggtt tcgtttcatc tcttggaccg atcaaaaact 2926681 ggggcctgga catcgagaaa aattccattg tcgtgaaatc aacaatggaa acaaatatcg 2926741 aaggcttctt tgcagcaggt gacatttgta catacgaagg aaaagtcaac ctgattgcca 2926801 gcggcttcgg cgaggcaccg acagcagtga acaacgccaa ggcttacatg gacccgaaag 2926861 cccgcgtaca gcctcttcac tcaacaagtc tttttgaaaa taaataataa aaaaaggagc 2926921 ttgtgtctgc gacacagctc cttttttatt tgaagatatt tatataattc aatgcagttc 2926981 ctacaaccag cgcaatcaca agggctgcga ctacccagat cattgccata ataatgcggt 2927041 cctgaatctt ttgggacttc ggtgtttttt cttcgttttg ggccatctta ttcgctcctt 2927101 tcccatgtcc atgccataaa gaaagcctgg tgctgaacga ccaagctttg ctgaacgtat 2927161 atcattcgcg ttttgatccg ctctctaaga ccattcgtta aaactatgat acctaaactc 2927221 accctgcatg acaagcttcg gcacttgcac cacacctgcc agcaaatcat aatgtttgac 2927281 atcctaaata aaacagagta cattatataa ggcgaacatt tcatatatta tacttttaaa 2927341 tattcgtttt taggagtgaa aaccatggaa aacgtatttg attacgaaga tattcagcta 2927401 attcctgcaa aatgcattgt gaatagccgt tcagaatgtg atacatccgt acgtttaggc 2927461 ggacatacat ttaaattgcc cgtcgtccct gccaatatgc agacgattat agatgaaaaa 2927521 ctagcgattt cattagccga aaatggctac ttttatgtga tgcaccgatt tgagcctgag 2927581 acacgaattg attttattaa agatatgaac gcacgcgggt tattctcttc tatcagcgtg 2927641 ggcgtcaaag atgaggagta tgaatttgtc cgccagctgg cagaagaaaa tctgactcct 2927701 gaatacgtga caattgacat tgctcacggg cactcaaatg ctgtcattga aatgatccag 2927761 caccttaaaa aacatttgcc ggacagcttt gttattgctg gcaatgtcgg aacgccggaa 2927821 gcggtcagag agcttgaaaa tgcgggagcg gatgccacta aagtcggcat cggaccggga 2927881 aaagtatgta ttacgaaaat caaaacaggc ttcggcacag gcggctggca attagcagcg 2927941 ctgcgctggt gtgccaaggc tgccagcaaa ccgattatcg cggatggcgg catccgcacc 2928001 catggcgaca tcgcaaaatc aatccgattc ggcgcaacga tggtcatgat cggttcacta 2928061 tttgccggac acgaagaatc gccaggccaa acgatcgaaa aagacggaaa gctttacaag 2928121 gagtacttcg gctcagcctc tgaattccaa aaaggcgaaa agaaaaatgt cgaaggcaaa 2928181 aaaatgcacg tggcgcataa aggctcaatc aaggatacac tgattgaaat ggagcaggat 2928241 cttcaatctt ctatttctta tgcaggcgga acaaagctta acgccatccg caatgtggat 2928301 tatgtgattg tgaagaattc catttttaat ggggataaat attaatcata aaaaaacgcc 2928361 aagtcagcgg ttctccgctt gagttggcgt tttctgctac ttcttcagca aagtaagctt 2928421 atatttgctt tttgagttta tcttccatca gttctgccat ttgttttgca tttggatttt 2928481 cttcattttg caactgttca atgacgttca tataatccgt ttcatttcgg ttctggctta 2928541 atttatatgc cgcttgaatg tcttccacct taatcttaaa tccaacaata cctttcaatt 2928601 cactttctaa gagttttgga gaaagcttat cccataacac aggattgtca cgatgttttt 2928661 cgtatttctc caacatgatt gttaattctt ctgctaattc atctttctct aacatacttg 2928721 cttttccata catgtggaca gcctgataat tccacgtcgg aacattttcg cgcgaatacc 2928781 aggaagaaga aatataagcg tgcggtccct gaaacatcac aagcacatct tcacaggctt 2928841 caaacgttct ccactgagga tttccataag cgaaatgccc cgtaatatag taatgatcgt 2928901 cttttttatt gaatcctaac ggcaaatgtg tggcaattgg ttttccttgt tctgttgtga 2928961 caaccgtacc aaaggagttt tcttgtacaa aattccaaat ttcttcagca tttgtgactt 2929021 taaaatattt tggaatatac atcatcatcc acccttcgaa aaatattata tgagtgtttt 2929081 agccatgatt aaatccgttt gttcttcatc acccatataa aatgagtggg cgccggtctg 2929141 aacaaacccc attttcttat aaaaggcaat ggcattttca tttttttccc acacacctag 2929201 ccaaatgttc tttttattac gttccagcgc aatttctatc gctttattca gcagatgttt 2929261 gccaagccca tgtttttgaa agctgttctt tatataaatt ctctcgattt caagtgattc 2929321 agcacccatt tcttcagact gagcatcatc gatattgacc tttacatatc cagcgatttc 2929381 atgatcaaag taaataaaaa agaattgcga agacatatta gataactctt tttccagctg 2929441 ctcagtgtta aatgcgcttt ctaaataggc tttcatattt tcaggtgagt tctgttcttt 2929501 aaaagtgtca ttgaatgttt caatactcaa ttgttgaagt gtttgtaaat cttcccggct 2929561 gcattttttc atttttacac tcattgttcg gattcagccc ctttatttaa aattcaattg 2929621 tcttgtgtcc cttttatata tttaaacacg gaacacatac tgaccttgtt accattccaa 2929681 aaatcttctt catcaccaac tccctatcgt gattttgttg taaatgcaat aaaatatact 2929741 ccgcattaaa tatatcgtaa ctttgctgta tttacaacaa aaatcaaaca acaaagcagc 2929801 gtttctcttg ccgaagttcc cggaactctc tgcatcattt ccccataata aaaacgcctc 2929861 ccttaacgat gatttatcgc taagaaaagc gtcagtaata gttgctatcc gtttttagtg 2929921 cttagcactc ttcaggcttg cctgcattcg ttgctgttct gaacgaagaa ccgcagccgc 2929981 atgaagcgat ggcgtttgga ttgtcgatgg tgaagccgcc gccgagcatg gattgtttat 2930041 aatcaatcac ggtgccgttc atgatgtcaa ggctttcttt gtcaactaga acagtgatgc 2930101 cgtgctgatc aaacacactg tctgattcac tcttttcatg ctcaaagccc atgccgtaag 2930161 aaagtccgct gcagccgccg cctttgacgc ctacacgcag aaacgcgttt tcttcttcat 2930221 gctctttcat catatctttt atatgcaaag ctgctgcttc tgtaattgtt accgggttgc 2930281 tcatcattat gaacctcctt ttaaaaaccg gttgctgtct tttattataa acatgatcgt 2930341 tccaattctc aaacaaggtg ttttacaaga aatagacacc ctcacaaacg gtttcagccg 2930401 gccctgtcat cattacatgg ccgttatctt tccagtttat caccaaatcc ccgcctgcta 2930461 aatgcaccgt gatgtcttga tttcgctttg atacgccgtt taatacagat gcgactgccg 2930521 ctgcacatgc tcctgtcccg catgcctgag taatccctga tccccgttcc cagacgcgga 2930581 aatgcaattc ttgttcattc acggtttcaa cgaattccac attgatgcct tccggaaatc 2930641 tcggatcttt ctcaatcacc ggccccagtg tcgttaaggg tgcctgttca atgtctgcga 2930701 tcggaaaaac gatatgcgga tttcccattg aaacggcagt gcctgttagt tctacttcac 2930761 caaatgccat cgtttcattg attgtgtgct cttccccgcc gtcaagcata ggaagctcgg 2930821 attttgtcaa gcgcggttcg cccatatcga cagtgaccac attcactttt ccgttttcga 2930881 cttgaacctc cgctttcaca agcccggaga gagtttcaat cagaaaagat gtttcctcaa 2930941 ccagcttatg ctcatatgcg tattttgcga cgcagcgcag gccgttgccg cagtttttcc 2931001 cttcagaccc gtcattatta aaaatccgca ttttaacagg cgcttggtct gatgggcata 2931061 tcaggatcat tccgtcggat ccgatccctg tataaacaga agaaacctga attgcaatct 2931121 ctgacagttt ttcttctgga agctgttctt caaattgatt cacataaata taactgtttc 2931181 ccaggccgtg cattttggta aatcgaaatg agttcatagg tgcctccaac tttttttctt 2931241 tttcttagta taaaagctat tataagcgga cacaatacaa ttatcccccg tttttcatac 2931301 ataaaagctc cttgcactga cgcaaggagc ttttatcgtt tatataaaca tgccggcaat 2931361 ggctgcgctg agcagattgg ctaatgttcc tgcaagaaca gccttcaggc cgagacgtgc 2931421 gatatctgaa cggcggctgg gcgctaaacc gccaagcgta ccaagcataa tcgcaattga 2931481 tgaaaaattg gcgaatccgc ataacgcgaa actgataatg gtagcagttt tcttagaaaa 2931541 ctcgccgatg tgcgaaccga agttagaata agcgacaaac tcattcagca ccaatttctg 2931601 gccgatatag cttcccgcct gcaatgcttc atgccaaggc acgccaatca aaaaggcgat 2931661 aggagaaaac acatagccga gaatggattc taatgttacg ccttttaaac cgaacaagcc 2931721 gaaagccccg ccgagaatac cgtttactac agcgattaac gcaacaaacg caagcagcat 2931781 cgccccaaca tttaacgcaa tttgcagtcc tgttgacgct ccctttgcag ctgcgtcaat 2931841 gacattggct gcgccttcgc cttcatccat tttgaaatcg ctttttacgg tttgcgtttt 2931901 ttccgtttcg ggtataatca atttaccaaa gactagtcca gctggagcag ccataaagct 2931961 ggccgccagc aagtactcaa tcggaatacc gagaagcgcg tacccaaaca aggtagatcc 2932021 cgcaactgcc gatagaccgc tcgtcataat cgtaaacaac tcagagcgcg tcagcccggc 2932081 aatcaggggt ttgatcacta acggagattc tgattgtcct acaaaaatat tggcagcagc 2932141 cgccagagat tccgttttgc ttgttccaag gagcttcgac aatccgccgc caatgacacg 2932201 gaaaacgagc tgcatgattt tcaaatgata taaaactgca atcagtgctg agaagaaaat 2932261 gataacgggc agtacactta atgcaaatgc cggactgtct ccgaccttta gaagcggtcc 2932321 aaaaataaaa ctgatgcctt cattcgcata gtcaatcaga agctgtacac ggcttgaaaa 2932381 ccataaaaaa acagcgcgtc ccgcttccca tttcaacacg atgtatccaa acgccacctg 2932441 tgtgcataaa ccaacgatga cggttcttat cttaatattg cttttctttt ctgaaaataa 2932501 aaacgcgata gcaatgatcg caactgcgcc cagcagcccc cacagaacat tcatgaatac 2932561 tcgtacacct cttaaatttt atttaaaaaa atatctttta tacgataaca ataatatttt 2932621 ttgatgtcta cacatttttt tagttctttt gtacggcaaa ataaaaaagg gcctgtccag 2932681 gcccttttct ttaaaacatt ggattttctt caataaaggt atatatattc tcaacaagct 2932741 cagcaggcgt ttcacccatg acgacttctc cgtttaccag agcgaaaagc gattccatac 2932801 atgtcccgca gtagcttaag cagccatatt caaggacatc aaggttggga tccttctcca 2932861 aaatcgcccg ggcttcctga gagccgtgag ccagattgct gacacaaaat tcaatcattg 2932921 gattcatgcg gtttcacctc acatatgtcc attatcgcga atttttcact attcgtcaaa 2932981 gacaacggat gattcaaaat ttattatcgt aacatattat ttctcaaata acgttttact 2933041 aatttgtgtt ttcaggctaa attgtaggtt attttgaaac tattattgtg attttagatc 2933101 aaattcgata taattctaga tgttatttta catagttcgt attttcttca atgtatctat 2933161 catactcttc ggattaaagg ggaattcaaa tgaaaaaatt ggtcttgatc ggcggaggtt 2933221 acgggaacat gcgcgttctt catcgcttat tgccaaacca gctgcctgat gatgtttcaa 2933281 tcacgttaat tgacagaaat ccttatcact gcttgaaaac agaatattat gcccttgccg 2933341 caggcacaat ttctgaccat catatcagag tgtcattccc agagcaccct cgcctggatg 2933401 tccaatacgg tgatatcaca tcaattgata ttgtacaaaa acaagtgctg ttccaagatc 2933461 gtgaaccgat ttcttacgat gacgccataa tcgggctcgg ctgtgaggat aaatatcaca 2933521 acgtgccggg agcgcctgaa ttcacctaca gtattcaaac catcgatcag tcccgcgaaa 2933581 cctaccaaaa gctgaataat ctgagcgcta atgccaccgt cgccattgtc ggagcgggct 2933641 taagcggcgt tgagcttgca agtgaattga gagaaagccg tgatgacctg aacattattt 2933701 tgttcgaccg cggtaatctc attttatcaa gctttcccga gcgtttaagc aaatatgtgc 2933761 aaaaatggtt cgaagagcac ggtgtccgca ttattaacag ggcaaatatc acaaaagtag 2933821 aagaaggcgt tgtgtataac cacgatgatc cgatttctgc agacgccatc gtgtggacag 2933881 ccggcatcca gccaaacaaa gtcgtcagag acttagatgt ggagaaggac gcacaagggc 2933941 gtattgtatt aacgcctcat cataatcttc caggtgatga acatctgtac gttgtcggcg 2934001 attgcgccag tcttcctcat gcaccgagcg cccagctggc agaggctcaa gcagagcaga 2934061 ttgtccaaat cttgcaaaaa cgctggaatg gagaagccct gcctgaatca atgccgcagt 2934121 ttaagctgaa aggcgtcctc ggttcactcg gaaaaaaagc cggcttcggg cttgttgctg 2934181 accgtccgct gatcggccgt gttccgcgta tgctgaaatc cggcttgctg tggatgtata 2934241 aacaccataa cggttaatga tagagaagaa ccgctgatca agtcagcggt tttctgtata 2934301 cccatgcttc tccatttcct cataaacgtc ttttaatttt ggattgcctt caccgacaat 2934361 tttgtcttct acaagcacaa gcggataaaa atactcgtca tttctgattt tttccgcaag 2934421 ctctttcgca tgttcattgt caggcggctc atgaatatcg atgtactgca tctcaaaagg 2934481 ctgatttgga tattttcttt tcagcgcagc ctcaagccac tcgtatgtat ccttggctgt 2934541 cggcatattt acacagctcg cacaaacgtt ttctgccccg tacacgctta gcatgactgg 2934601 tttcatcact tgtagacgcc cccttctcct atgtaagtcc tttcttttaa gtatacagag 2934661 cctaagggcg tttttataga aaaaaaccgt ttttgtgttg aagtctgaat gtgctataat 2934721 agggaaagca actttgcaaa ccaaacaata gatttttatt gttacactga atataatggt 2934781 tttatgacga cgaaaggagc gaatgtcatg actgaagttg aaatgaaaga acaggtgcag 2934841 gaagtactgg acaaacttcg tccgttttta cttcgtgacg gcggtgactg tgagcttgta 2934901 gacgtagatg aaggtatcgt taagcttcgt cttctaggcg catgcggcag ctgcccaagt 2934961 tcaacaatta cgttgaaagc cggaattgag cgcgctcttc ttgaagaagt gccgggtgtc 2935021 gttgaagtag aacaagtctt ttaataaagc agccaggctg atatttgatc agcctggctt 2935081 ttttattaga gatgttgatc aaaccatgag ctgatataat tcaggcgctt gatccgctgt 2935141 cttgggtgtc cggtgcgtga taaattgtgc gatgcattcg gaaaacggac aagcttggtt 2935201 tccttgccca tttttttcag agcgataaac agctgctccg cctgctcgat cgggcatcgg 2935261 tcatcccgct cgccatgcag tatcaaaagc ggtgtctcca cgtttgctgc gtattttaaa 2935321 ggagaccggt cccagagctt ttctgtgtcc tcaaacatgt catgctcaag ctgccagtct 2935381 gtaaagaaat agccgatatc actgacgccg tgaaagctga tccaatttga tatcgagcgc 2935441 tgggtaacgg cagctttaaa gcggttcgtc tgcccgacga tccagttggt cataaaacct 2935501 ccgtagcttc cgcccgtgac accgagccgc ttaggatcaa tatgcggatc tcgtttgata 2935561 gcctcatcca cagcctgcat cacatcgtca taatcctttc ccccataatc tcctctgacc 2935621 gcattcacaa attcctgccc gtagccgtgg cttcctctcg gattgatata aacgaccgcg 2935681 tatcctttcg ccgccagcac ctgaaactca tgaaaatatg tatgtccgta catcatatgc 2935741 ggaccgccgt gtatgttaag aataagtgga tatgttgtct caccttccat ttgtgcaggc 2935801 ctcatcagcc agccgttcac catcacgccg tcttctgtag catattgaat ctcttcaggt 2935861 attgatatcg tatgctccct gacaaacttg tcattcgcgc cagtcagctg tttctcttcc 2935921 tgtccaagcg ggatactgta aagctcactc ggtctgtccg gctttgtcac actggcaata 2935981 aagtgctgtt catcaggtga aagagaaaag ctattgatgt actctttttc cagacgaatc 2936041 ggatacacaa ggccttcaat cgaaatataa tagatgcccg tactgccttg atctgtgccg 2936101 atgacataaa acccttggct gtcctttgtc caaatcgggc gctgttcagc accaccgatc 2936161 aatgaatctc caatcagcgc atccgctaaa tgaacgtcca gcatctcagt aagacatgtg 2936221 aggcggcctt gttcgatatc atagagccac gcctttgaga gcgtagcatt cttatattcc 2936281 ttttcatttc caagcaaagc aagatacctt ccgtctggtg aaaatgagct tgatccgaat 2936341 gagccgcgat gaggtgtaac ctgcttaaga tctccagact ccagtgacat tatgtaaaca 2936401 tcatgcggct tgctggcatc atctgtttca gttaaattag ctgagaaaac aagccatttg 2936461 ccgtcaggag aaaaagcagg atcaccatga tcagctttgt gacttgtcag ctctttcatc 2936521 tcacccgact ttacgctgac aagcacaagc tgggcatacg cacctctcgt cagccctttg 2936581 ccgtcccgtt tgtaggagag gccttgcact tcaacaggtt catagctgtc ctgctctgtt 2936641 ttttctcggt catcaatgct ttccccctct cccaaactga cagtgaccag aatcgattca 2936701 ccgtccgggg accatagcgg ctttgacacg ccatatggga tatcagtcag ttttcttgct 2936761 tctccgcctt cagtgctcat gatataaagc tgtgccgcat cgccttctcg atcagaaata 2936821 aaggcaagcg tgcgcccgtc cggagaccat cttgggtcgg tgcttcgctt ttctccatgt 2936881 gtccaaggaa cagatcctcc cgttttcgtt tcatagatcc atatatttga tgtatacgaa 2936941 tctttctctt gatttacttg tgattttaca tatgcggcac gggtaccgtc tggggcgtat 2937001 tgaggatcgg tcacagagac aatcgctgtg atgtcgtctg cggttatcag ctttttcata 2937061 ttcatctcct cctttttaca tgtatttcgt ttttctaaat aaaaactcct ttatctccag 2937121 caaaaaaaag cgccctccgc tgacgctgag gaacgcttgg catgatctat acacttttta 2937181 cttgatataa aggatttcgc tctattatac ttccctcttt cggaacggtc aaagcgtcta 2937241 cttcacaatg agggaaatga agcgcgagct gttcttttag ctcttctccc tttccttttt 2937301 cggtcatgac gagaatcgtt gggcctgctc cgctgagagc cgttccatat gcgcccttca 2937361 tctcggcgac gtgctctact tttgacagct caggcacaag catcgcccgg tacggctgat 2937421 ggaacatatc cttcttcatg attttcccga caagcggcca atccttggac atgatcgcag 2937481 caatgaggat attgctgaca gcacttgctt ttacggcatc ggcatatgga aactccttcg 2937541 gaagcacgtc tctcgcgtct cttgtcagca cttcataaaa aggaatgaca acgactacgt 2937601 caatgtcagc attcgggacg cggatcattt gggtctcgtc atcctcatgc aggccgatca 2937661 caagtccgcc gacgagagaa gcgccagcat tgtccgggtg tccttcttct agactcgcta 2937721 aatgcagctt gtccgcttca gacagcttta agccgcataa ttcatcagcc agttcaatgg 2937781 ccgctacaat cgctgcggcg ctgctgccaa ggccgcgtgc aagcgggatg tcgctccaca 2937841 ccttcacatg gacaggaggc atttcttttc cgtacaaatc tgcggtccgt ttagccactt 2937901 ggtagatcag gttatctgta cccgccggaa ttccggcgac tgtttctgtt tcagcctcaa 2937961 aagaccattt gtcgctttca aagacggtca gcttcaaata tctgctgagc gccattccga 2938021 ctgaatcaaa gccggggcct aggttagctg tgcttccggg aacagtgaca gagaacagca 2938081 tgtcggcttc gttcatacac gggccgctcc ttttacatat tcaaggatgc tgtcttcatc 2938141 agtcggcaat gtgacaggct tgatttctga aatgtcgacc gctgtgttcg gatctttcag 2938201 tccgtttcct gttaacacag ctacgacctt gctgcctttc ggaatttctc cggatttcac 2938261 ctgtttcagc actcctgcga tagacgcgca agaacctggt tctgcaaaca cgccttctac 2938321 acgggcgatc agctgatatg cgtgaaggat ttcatcatca gtgacttcgt caattttccc 2938381 attggattcc tcggctgcct ttacagcttt gtcccagctt gccgggtttc cgatacgaat 2938441 ggctgtcgct attgtttccg gattttcaat cacttcattg cgcacgattg ccgccgcacc 2938501 ctcagcttca aagccgcgca ttttcggaag gcctgtgccg tttttctcat gatattcctt 2938561 gaagcccttc cagtacgcag tgatgtttcc agcatttccg accgggatcg ctaaaacatc 2938621 aggcgcttcc cccagctgtt cgcacacttc gaaggcagca gttttttggc cttcaatgcg 2938681 gtaagggttg actgagttga caagggcaat cggtgatttc tcacagatgg aacggacaat 2938741 tttaagcgca tcgtcaaagt ttccgtcaat tgcgataatc tcggctccgt acatgacagc 2938801 ttgagcgagt tttccaaatg caatttttcc gttcgggatg atgacaatgc atttcatgtt 2938861 agcacgggct gcatatgctg ccgcagcagc ggaagtgtta cctgttgacg cgcacataat 2938921 cgtgtcattg ccttcttctt ttgcctttgc cacagccata accattccgc gatctttaaa 2938981 tgatcccgta ggattgacgc cttccgtttt gacatgaagc tcaattccga gctgctcaga 2939041 cagcttcggc aggtgaataa gaggtgtgtt tccttcatgt aaagttagcg ccggtgtttg 2939101 atctgttaca ggtaaaaatt ctttatattg atggataagt cctttccaca ttagctccaa 2939161 ccgttccctt ctacacgata tgtgcttttg acttcttgaa cgacttccaa atcatttagg 2939221 ttttgcagga tatcactgaa atcagcttct gatgtatgat gtgtgacaat tacgatttca 2939281 gctaactcat catggccttt aattggcagc tgaaggattt tttcaaagct cacgccccgc 2939341 tctgagaaca cagatgtaat tttcgagaat gaaccaacct catcttttac atgaattctt 2939401 aaaaactgct gtgcataaat gtcagacggc gatttcatgt ttttctcata ttgcggtccg 2939461 acaaagctgt tgccggttac acctaggcgc atatttttca tgacagcgac gaggtcagaa 2939521 acaacggatg tcgctgtcgg catgcttccg gctcccggcc cgtagaacat cgtctcaccg 2939581 acagcctcgc cgtatacata aacagcgtta aactcattat gaacagcaga aagcggatga 2939641 tggtcaggaa gcagtgtcgg ctgtacgctg acctcgattt tgctgccgtc acgctgagca 2939701 atcccgatca gcttcattgt atagccgagg cgtttgctga agctgatgtc ctcgtctgta 2939761 atttgggaga tcccctttac tttgacgtct tccagatcca cgttcatcga gaagccgagg 2939821 cgcgccaata tcgccatttt ccgtgcggcg tcaagccctt ccacgtcaga agtcggatca 2939881 gcttcggcaa aaccgagatc ctgcgcttcc ttgagcactt cctcgtatgg gcttttctct 2939941 ttgatcattt tggttaagat aaagtttgtt gtgccgttca caattcccat catttttgta 2940001 attcgatctg atgagaggcc ttcctctaac gtgcgcagaa tcggaatccc gccggcaaca 2940061 ctggcttcaa agtagatatc gcatccattt tccttcgctt cggcaagcag ctcggagccg 2940121 tacacagcca ttaagtcctt gtttgctgtg acaacatgct ttttcgatct cagcgcgtcg 2940181 accaaatatt gttttgtctg ttcaacgccg ccgatcacct cgatgacgac atcaacatct 2940241 ggatcatcaa tgacatcata cacttctgtc gtgagcactt ccttcggcaa atctacttct 2940301 ctctttttct ctaaatcttt tacaagcact ttttttatcg taaccggaca gccgacctga 2940361 tgcataagct tatcctgatg gtcttgaata attttaacga caccgcttcc gacggtacct 2940421 aaacctaaaa gccctacacg aatcgctttc aaaaaaactc cacctttctt ttgattgtcc 2940481 tcttggaaaa gacaattgtt aactcaacac agacatataa gttacaaaca ttatataagc 2940541 ccgctcctgt tttgacaaga catcattagg ctgaattttg cgaatgtaaa cgcttaacgc 2940601 attgatatga caagattctt tattttctaa ttatttttgt cagattttct cctcaccttg 2940661 agctgccttt gccgagccag ctgacgcgtg gaacaaacag cttctgcgcc cgcatattca 2940721 tgaattcctg cgctgtattg agaaattgtt cataacgccc acagtcatta agaatgaagt 2940781 caagctgttc ttcaaaataa tgcttttctg attctgatga catgtaatag ctttctacga 2940841 tttcaaaata atgaagcggg aaaagcagac ggctgtataa aaggcgtttc gaaaatgaag 2940901 acagcggtgt gacttgctcg tattcctgta aaaagagaaa gccctgctga ttaaaatctt 2940961 gtctgtgatg caaaaacgta tgcctcatat attcagccaa atcacgggaa gcgtggtcaa 2941021 acacccaatc cgccggaatc ctgatcaatg attccggtga ccatgtatgc ctttccatcc 2941081 gctgatggca tatcgttcct gaatcagcgg cttggggctt gtcatccagc tcagtgtcca 2941141 ctaaatattg tatcgcgttt tctgacagtc ctaaataata tggaaatgat tcgatcattt 2941201 ttttatcgaa tggctcatgc ggaggggtct gaacctttct ctgccaaaat gcttccagct 2941261 gatcaattcg ttttccccac agatccttcc actggccgat tcttccggcc gccttcacct 2941321 catatggata tcctcggcct tttcggtgaa attccgcaag ctccgctcca atggagaacg 2941381 ccctgtttga ataagggggg gccgccttca gcagagcgta cgtttttccc tcatgttcaa 2941441 atgtcagttc accttctttt gtaaagataa aaaccgaaac gtatgggtca ctttgttctt 2941501 gtaaatactg actcatgtaa taaagctccg ccagctctgt ttctgagaat tgggaaacgg 2941561 ggacaatcag aaagtatgaa ttaggcgtct gaaagcattg atatgtgtgc tggtacatgg 2941621 aaagctgcct gatgtgaatg ccgtattttt cttttattgt acctttcacc atgatcacct 2941681 gcctgttgaa ttagggctca tcacatcgta gtcatacaca gccggaatta tgaatacata 2941741 ttttaatccg aagaaggcgc aagaaaaagt cgtaaacttc tcaagcattt tgtataaact 2941801 agtaaaaaag attgggtgaa gctgatgtca gaaaacgaac aattcagtca gatggaagct 2941861 aaagcaagag cacggatgaa ggagcgcggc gttgaggtat cagacattgc cgagcttgtc 2941921 ttttttctgc agaaaaaata tcatccggat ttaaccattg atgaatgcac gctgaacgtc 2941981 aatcgtgttc tcgcaaaacg cgaggtgcaa aacgcgattt taacgggcat tgaattggat 2942041 gttcttgctg agcagaaaaa attgtctgaa ccgctgcaaa cgatgctgga aatagatgaa 2942101 agcctatatg gagtagatga agttctggca ttttccattg tgaacattta cggatcgatc 2942161 gggtttacga actacggtta catcgacaaa gaaaaacccg gaatccttaa acgattgaat 2942221 gataaatcaa ccggtgaatg ccataccttt ttagatgaca tcgtcggagc gatttccgcc 2942281 gcggcttcaa gcagacttgc tcaccgcgcg cggcatacag aataagggca cccttttagg 2942341 gcgccctttt ttcaaatgta tggaatccat tcagtcagag agtcaatggc gtgagtcggt 2942401 ttttccatat cgtctgtcat atgttctctt ttcgttacgc ctgtgtgaac gagcagcgta 2942461 tccatacccg cgttaatgcc ggccataata tcagtggcgt agttgtcgcc gaccatgagt 2942521 gtttcagaca catctgtgcc gagaacgcgc atcgcctgct ccataataat tgattccggc 2942581 ttgccgataa atacaggctg tacacctgta gatacggtta acaccgatgt cagtgagccg 2942641 tttcccggca ggagccctct ttcagtcgga atcgcaatat ctccgttagt ggaaataaag 2942701 cgggcgccat ttctgattgc caggcagcca acagcaaatt tttcgtatgt aatggaacgg 2942761 tcgatgccaa caacgacaaa atccgcgttt tctccgccaa atgtcaggcc gttttcttca 2942821 atcgcctggc ggattccttc ctccccaatc acatacacag acgcgtcttt tttctgctgt 2942881 gcaatgtgct gggcagttgc catgctggtc gtgaagacct gctcttctgt tgccggaata 2942941 tcaaaagaca cgagcttgtc cgctacctgc ttcggtgtgc gcgaagagtt gtttgtcacg 2943001 aaaagataag gaacgccgcg atctttcagc gttctgacaa attcacacgc ctcctcgatt 2943061 ttttccgtgc cattgtacat cgttccgtct aaatcaatta aatacccttt atatgttttc 2943121 atatccaaca ctcctgtggc tttccagttg ttatttaaac gcggaaacag gtcctagctc 2943181 tgtttccaaa tagcttctga tccgtttcgg gaagtcctga agagctgttt gatgcgcctt 2943241 gatcagcctg taaagctcgc cgctgtcagc gagcagatac tgttgaacca acgttttgcg 2943301 gtaggcgatc aattttttga gctcatcacc ctctttttcc gtgacaactt tctcatcaac 2943361 aagtatatcc ataatgtcgt catagctgcc cgggtcccgc ataataaagc cgtcaatcat 2943421 gtcattgcct gtatccaaaa tgcattcgat taacagatgg cctatacgct gaagtgccaa 2943481 ttccccgatt tcagactgcc agtctgtttg tgagtcaaat agcgccagct ggtgctcgaa 2943541 gaaccctagt gttttttcga ttttgcttct gtcaacaaaa tacatgacag catccccttt 2943601 gtgtatattt attttctgat ccgtttcaag acaaaatacg cacagccgaa attgcagtat 2943661 tcgtaaatat attcatctaa tgtgctgatt ttcgtttcga aggttgcctt ttgattctgg 2943721 tcgtcaaaga agcccttgag ccttaactga ccgtatcccc agtctcccac aatataatcg 2943781 tatttattta atatatcgga gtagcgggct ttaaaagcct cttcgttgaa gccgtctttg 2943841 aaattgtgca ccaattcaaa ttcggcattt tgaataagaa tcatgatctc acctcttttt 2943901 tcactcattc ctatcataat tcattgcccc gtccccatca attgctaaag aataaatcat 2943961 gcgatttggc taccctacac atgaggaggg attgataaat gaaacgaacc gctgtcagcc 2944021 tctgcctgct gaccggacta ttatccgggt gcggaggcgc aggattggat aatgcccaaa 2944081 atgtccggaa tcagacgcag aatcaaacca aacccattca tgtgtcggac cgcaacgagg 2944141 cttttaacag gcataatgag aacgaacaat ttggctatgt ccgctatcaa aaagaacaat 2944201 ttgacggaga acagcagaaa acgccggtga tgaaccggga agaaaccgct cacatgatat 2944261 caagtttaac ggttcagctc ccccatattc aagatgctgc gacattggtg actgaccgag 2944321 aagcgcttgt cgtatacaaa accgattcta aaaaccggga gctgaccgcc gatcaggtga 2944381 aaaaaacagc ggcttctgtg ataccgcgat actatcacgt gtatatttcc gataatccaa 2944441 accatatgca atccgtcgaa aattacagca atctcggctc tggttcaagg gatattagag 2944501 agatcatgtc ggggacgatt caagaaatga aaacctcccc gcaaggaagc cctgtctcag 2944561 agaatgaaaa tgccaatgga gaaacgcgtc aggacatgaa aatcgatagg aatgacaaaa 2944621 acgccagatg atctggcgtt ttggcattat gcttgtgctt gacgcttttt agatgcttcg 2944681 tttacttgtt catccgcatg gtaagaggaa cggacaagcg gaccggcttc acaatggctg 2944741 aagccttttt gcatcgcgat ttcttttaat tctgcaaatt catcaggatg gtagtatttt 2944801 tggactttca agtgtttctt cgtcggctgc agatattggc cgattgccat aatatccacg 2944861 ttgttcgcca agaggtcgtc cattacttca ataatctctt cttttgtttc gccgagtccg 2944921 atcatgatac ttgattttgt cggaatgtca ggctgcattt ccttcgcacg gcgcaaaaat 2944981 tccaatgaac ggtcgtacgt cgcacgcgcg cggactcttg gcgtcaggcg gcgaaccgtt 2945041 tcgatattgt gattcaggat gtctgggcgt gtatccatca aggtttttag gttatcgtag 2945101 tttccgccca tatcagacgg cagcacctca attgttgtga acgggctttt tctgcggatc 2945161 gcacggacag tttccgcgaa aatgcctgcc ccgccatctt tctgatcgtc acgcgcaaca 2945221 gccgtaatga ccgcgtgttt caaattcata agcgcgactg aatccgctac gcgttccggc 2945281 tcttgcagat caagctcagt tggaaggcct gttttgacag cacagaaacg gcatgctctt 2945341 gtacaaacag aacctaaaat cataaatgtc gctgtacgtc tgaccgccca gcattcatga 2945401 atattcggac actttgcttc ttcgcatacg gtatgcaggt tgttttcccg catgagtttt 2945461 ttgagccctg tatagttttc atttgtattt aatttaattt taagccattc gggctttctg 2945521 aggtgttcgt ctttctttgc caattcccat catctccaat atccaatata ctcaatttct 2945581 gacacgaaac attctgaaaa cgagaaaggt gcaggtttta gttctgcaac aaaaataatg 2945641 tttttctaac taaagaaagt cttttcttta gacactttaa cataggaaaa atttctcgac 2945701 aagggaagat gattactgac atttttaagc cgggttgccg caaactatgt gtattcaata 2945761 tgaaaggaga ttattttgtg aaagttttgt tatccgctct tcttctcctt ttgtttgcat 2945821 ttgagccttc tgcgtctgga aaaaaacttt cagatccagt gctgtcgaaa cggatggaat 2945881 tatatcataa aatcgaagct gtgacgcaga tcccttggta tgcgctcgcc gctgttgatc 2945941 aatacgaaga aaacgtgcgg agcaaccgga aagatctgcc tgaaaaggcg ggaatcatca 2946001 gcatctatat acccgatgat atctggagcg ggcctgaaaa cccgaatccg aaagacgatg 2946061 cgccgttaag cattaaagtg tttgacggaa tcggaatgga tggcgatgga gacgggaaag 2946121 ccgaggtcag caacgatgaa gatatcttgt atacgttcag ccaatactta ctgtcgtatg 2946181 gcacagatga agacaacatc cggatcgggc tttggaatta ttaccggcgt gatcagacag 2946241 tggggattat atctgaattc atgaagctgt ttaaagccta cggccatatt gatctgggcg 2946301 agcatgcatt cccgcttccg atcagaaccg attacagcta ccgaagcacg tggggagatg 2946361 cccgcggctt cggtggaagg cggattcatg aaggtacgga tatctttgcc cattacggcc 2946421 ttcctgtcaa atccacatgt tacggcgtag ttgaaatgaa gggctggaac cgcttcggag 2946481 gatggagaat cggcatcagg gacattaaca atacgtatca ttattttgcc catctcaatg 2946541 ggtttgccaa agggattaaa acaggacaaa tcgttgagcc tggccaagtg atcggatcag 2946601 tcggcagctc cggatacggc ccgccgggaa ccgccgggaa gttcccgccg catctgcact 2946661 atggcatgta caaagataac ggaagaaccg aatggtcatt tgatccatac ccgcatttga 2946721 gggcgtggga gcgatatgaa taccaaaaaa agaagtaaca aaaagccgcc tcttcaacag 2946781 gcggcttatt tgctgctttt ttcttttttt gaatcggcac cgttttcttt gctgctcgga 2946841 agctggacag aaggcgtgac acccgagccg ccgcttccat tataaaactg cggcacttcg 2946901 ccctgcactg ctttaatcga tacaggaaca ttatttgtga cgacagcggt tttgctggca 2946961 aatggaatga tgaccttcac tttaatttcg acaaagatgc tgatatcaat aagtgcgtta 2947021 tttatgccat acggcttgat tttggttttg acatctgtaa aagcgtcacc gattaaattg 2947081 aaccggaccg ggattttcgg cccgaggttt ccaagaaggc tgttgccggt tacctgtccc 2947141 agcggaatgt tgatcataat gttttcactg gcgccgctgt gtccggtatg ggtttccatc 2947201 tctttcaaat gagcctgaag ctgctttgtc acttttgttt tcacactgtt tacaacctgt 2947261 gtattaaaat cgattgtcgt taagtttccg ttttcatcag aattcatttg aaacatatct 2947321 ttcatatttt cactgtcaga catatagtcc tcaatcgaat cctggatcac ctctgtcgct 2947381 atacgcttcg tttccatctc gccgatgtcc attaaaacag gtttgatcga gccattgatc 2947441 atccaaaggc tgaccgttgt tgacaggata aaaaagacaa cggacaggag catcacgtaa 2947501 cggaaaggca aaggtcctct cttgcgaaaa gggccgcgat atcttggcaa gaaaatcccc 2947561 ccttacatat cacaatgtat gcttgtaaga ggggacatag taatagccgg ggccaattta 2947621 ttttatttca tcatttttaa aagcgcttct ctgccgctca tgccgacttt gatgccaaga 2947681 tcttccgcag cgtacgtgac ggattctaaa ggtgcgtcta acagctggtc aatggtgcgg 2947741 acaccaactg cgcgtcccgc cacgatgccg cgctccttta atttttcatt cagcagcgcc 2947801 acatcaagcg cgccgcacat aatgtatccg tgatcattgg cgacggccat aaaattcgtt 2947861 ttgggaagct ttactgtcac agctgtaaaa ggctgtcctt ctatcatgat cggtgtcagg 2947921 tttaccacgt caaccactcc cttcattcat cactttatga tgaagggcac agcttgttgt 2947981 gggctgactg ccttattgtg caagcttcca agcaagcaga tcccgcaaaa attccggcat 2948041 aaaatattct ttttctgcag cgtcgcgaat caacggaaac agtttgccga gcgtaaacat 2948101 atcaagcacc gcaacggagt attgtttatg tttttcaata tcttccccgt tcagtgtgat 2948161 ccgagtgacg tgggtgatcc cgtcatcgag ccgtttcgtt tctacctcaa cgccggcata 2948221 caccattttc cccatcactt ctccgcggaa gccgagtcct ttgatccgga gctgctccat 2948281 ttgttcggaa gcggcatgga caatggtttc cttcagttct tctcccgtca ggcggacagc 2948341 caccgggttg atcggatgcg gacagatgcg gtgcagatcc agctttgtca caggacctgc 2948401 ttttagcgga ccgagaatga cacctgaatt gaccatactg atgtccgtct cgcaccattc 2948461 ctttaaggcg tatgccaaaa gcaaaggcag ctctgattct tcaaaccact tcacctcagc 2948521 atcttgtgca agctctgcaa cggcatcgga cagtttctcc tcggcttcac gttctttttc 2948581 attgagaaac gctttagttt ctgcggattc tcctgtccat tccgccatgt tctgcacaga 2948641 agccgttttg ctgttgatgc ttcgctgtac gctgtccacc gtgatttcta cacagccgac 2948701 ataatgcccg tatttctcgg cgctggccag cagtacccca ttaaccactt gtccatcttc 2948761 gagcaaatga tgggtatgtg attcgaggat tacatcaatc tcaggcaccg cttcagccac 2948821 tgcttgatca tcaagaatgc ctaaatgtga cagcagaacg ataatatcag cctgcccttt 2948881 cacttccaga atggtttcct ttatgctttc aagggcatcc gtaactgtcc atcccagctt 2948941 gtcatataca ggataatacg gcacagttac acctaagaaa gcaatggaca taccgttttt 2949001 caatgatttg atatggtaag gcaccgccca ggacggacgg tttccatttt tatcaaacag 2949061 gttagagacg atgacaggaa attcagcatg atcatataag gcagcaagct cttcatgcgg 2949121 aagcgtaatc ccttcgttat tgccgatcgc cgctccatca atgtgaaggc ggtttaagag 2949181 atcgacattc gcttttccga atgtcgcctc tgtcacgaat tgaaaacgat caagatgatc 2949241 gccaatatca aaaacgagcg tctcttcgcc gtctgactga tgctcttttc ttttctgctc 2949301 gatataatct acaattttcg gccagttttc aaaatggctg tgcaaatcat ttgtatgata 2949361 taagcggagc ttctccttca taatatctct ccctaatcgt tcagctgaaa atgccttcat 2949421 aaatgagctg gcagccgatc aaaatcaata cgatccgcat gatcataacg atcgttttcg 2949481 tctgcatttt tctgttgatg gcggcgccaa gctttccgcc gaaccaagcg ccgggcacaa 2949541 gcgcgagggc gtacagccaa ttgacgtgcc cggaaatcat atgtgaaaca gaccctgtca 2949601 tagaagacag gaaaataata aacatggacg ttgccaccgc aaccttcggc ggaaacagaa 2949661 ataacagcat catcgccgga accatcagtg atccgccgcc tataccgaaa agtccgccta 2949721 aaaaaccgac aacaaaggca atggcaatac cgacagaggc ctgatatgag tacgtataag 2949781 gctcaccggc atcatcctga aatgtccgga taattccttt gtgcgctttg ttgattggcc 2949841 gggctttcgc tttcagcatt aaggataatg aaatcagaat cataaaaatg ccaaaccaaa 2949901 cggaaaacga gtttgaattg aacagctttg acacgtaagc cccgatcatg ctgccgggac 2949961 ccgaaccgat aaagaaaatg agtccgctct tataatcaac tgttttatat ttaatataag 2950021 ccaaagttga agaaaggccc gtaaaaataa tgaccaaaag cgaagttcca atcgcaacct 2950081 gcggcgtcac atcctgaaac agctgcgtca ctgtgcttaa aaacatcaga gatggcacaa 2950141 tgacaattcc gccgccaagc ccgatcagac ttcctaccgt acctgcgatt aatcccagta 2950201 cgaccaaaat cacaaacgac atcaatcaaa acctcttttc taaaataaat cgagctgtct 2950261 cggagcaagt ccgctgtact cgatatcaag cagttcaagc atctgcttgc cattatccgc 2950321 agcgtcaccg ccggaattgt tgttgaacag gacaaaaaca tccttacatt gctgctgcaa 2950381 ttcattcagg tgctttttcc aatcctccag ctcctgttgg ttgtagcggt ataagtacct 2950441 gacctcccgc cagtttttcc cgccatcagg cttcatccag ccctgcttgt tgcgtccgtg 2950501 aaacctgacg agcgttttgt tttcatcggt cgcgcgcaac acggtcggaa cgctgccttc 2950561 tccgatttgc ggttcatcac agacactgtg aatccagcct tccgctttca taaatgaaag 2950621 cgtctgctca taaaatggcg gcgagaacca ggaacggttt ctgaattcaa gcgcgcaagg 2950681 aatatctccc atttggtgct tacaccatct caaataggcg acattctcct tcttgcagtc 2950741 aaaccacggc ggaaattgaa acagcaccat ggcgagctta ttgctatgta aatatggcgt 2950801 taaagacacc ttaaacgcat caaacatctc ctcttttgag tcaaagggaa tttcgccgcg 2950861 ctgatgccct gtcatgccct gatatgcttt cacgataaat tggaaggttt cgggcgtttc 2950921 cttcacccac ttttcattat tgcgcgccgg ctgaatcgcg taaaagctcg cgtctaattc 2950981 cacgatcgga aaatgggagg aataggcctg caattttttc tggctggccg ttttcggcgg 2951041 atagatgctg tcatgatccc cccatcccgt cagtccgata taaatcacac tcattcacct 2951101 ctcttccagt ttatcacacg tgttttcagg tttcctcgga aatgctgttc atatggcggg 2951161 aaaatgcctc acgcaaatgc tgatattgtt cctcattcgt atctaaaaac gcctcttctc 2951221 ttgaggaagg aatgtgctga tattcaatag gcgcctgaaa ctgctcactc gtaaaatcgt 2951281 acaccacacc attgatgctg ttataaaaat gccagctctc atcgactctt gttttgaaaa 2951341 tcgtgccgcc gaaatggtct tgaatcacca atgccgtcac gccgcattgg ccgcatgacg 2951401 ggcattcttc cgtccattta gagctcgaat ggcgcgacca ggattgctta agtatgtatt 2951461 tgacatgctc cattgcctcc gcctccttta aaaaaagata ccacgttgat gagattttaa 2951521 aaactagaac ggaggaaatc aaaaaacccg gcggtaaaat ccgccgggct tacgaaggaa 2951581 cgaccagagc tccgtcaatt tcagtgactt tttccccatc attgtacacg caccggcctt 2951641 tgctgtaagt ggccgaaatg ctgcagggaa atgtatgtcc ttcgtaaatg ctttttttat 2951701 gctttgcaaa catcgattct cttgtaacag tgtacggctc catgctgacg agcacgaaat 2951761 ctgcatcaca ccccgcctca agccgccctt ttttctgaag gccgaatcgt tttgcagggg 2951821 ccgccgctgt ccattctgcg atggtttcaa atggaatctg atgctcaagc gccagttcca 2951881 gcattcctaa taaagtgaac tgcccgccgc tgattccgcc ccatgataaa aacatgttat 2951941 cctcccgctt caaggatgga cggcaagggg aatggtctga ggaaaccatg tcaatgtccc 2952001 cggcaatgag cgtctcgatc agcgtctctt ttgattgccg tgaccggagc ggaggcgcgc 2952061 attttgcgac agagcccctt tgccgtaaat cgtcatggct gaacaagaca taatgcggac 2952121 atgtttcaac cgaaacatca agaccttcct gtttcgcctc tctgatcagc cggaccgctt 2952181 tcgccgtgct gatatggaca aaatgaaccg gacagcctgt caccttcgca tactgaatcg 2952241 tgcgatacac cgcttcaact tctgcttcct ccgggcggga ggcggcgtac gcatccgcat 2952301 ccacctttcc tttattggcc aaaaccatct gcaagtagct tgtgatcgcg tcgctttccg 2952361 cgtggagagc gaggattttt cctgcagccg cgatttctgc catgcctttg agcaatgtcc 2952421 gttcatcaac agagcggaac tcatcagtgc ctgactttga taaaaacgct ttaaacccga 2952481 tcgctcccgc ttcagccatc ggacggatgt cctcgatatg gcctggcaca aggccgcccc 2952541 atagcgcaaa atccacggca gatttttgcc tgcctagctc agcttttgcg agaagatgct 2952601 ctgccgtcac ggttgatgga atacagttga gcggcatatc aaaataggta gtgcaaccgc 2952661 ctgcggccat catttgagaa cctgtttcaa acccctccca atcctccctg cccggttcat 2952721 taaaatgaac atggcaatct atcacaccag gaaacacgta tttcccgtct gcctggatga 2952781 tttccgtccc gcttgcttca atgtcagaac ctatctcggc aatgacaccg ttttgaacta 2952841 caatatcagc ttctataacg ccatctggcg taactgcctt cgcacctttt atcaccatat 2952901 cgtaagccat attgatcccc ccatgtcagg atgacgattt tccatgtcag tttatgtaac 2952961 acaaccagtt ctattttcaa cagtttactg ctactatgat cgtattacat cagcaaaacc 2953021 gctagaattc ctattgaaaa ttattcacct taaccaatgt ttttatagaa aaggagaatg 2953081 cgctatgaat attcttgatg tgatgaaaat accggctttt gaaaacgcca atttaatcgc 2953141 tggaaaagca ggaggggaaa gagaggttca gcatgtcaat atgatggacg ctccggatat 2953201 cgtagacttt ttgcataaga atgaattgct cgtcaccacc gcctatcacc tgaaggatca 2953261 cccgcatcaa ttatctgaac tgattcggca aatggcaaaa cgcggctgcg cgggcctcgg 2953321 cattaaaaca aagcgctatc tggaagatat cccgaaggaa atcatcgaac tggccgattc 2953381 atatgcgttt ccgatcattg agcttccgga acacatccga ctcggcgata ttgtgaatgc 2953441 cacactcagc catattctcg atatgcgttc taacgagctg cagcaagcca tttacgcgca 2953501 caaaaaattc acaaaccaca ttatgagcgg caaggggctg caatccctcc tcaaaaaggt 2953561 gtcagacatc cttcagcttc ccgtgctgct gcttgaccag catgccaaaa tgctgtctgc 2953621 gtctcatcag atttcagttg agaccgaaaa gctgaaaggc accctgaata ccgtatccgg 2953681 gccatttttc acttgtttct ctacaatctc agatcagaaa acatattctg tcctgcctat 2953741 ttataatcac gaaaaaaact gcggctacct gctgataccc gacatggtgc aggcaggcga 2953801 caaaggattg atcctcacga ttgaacaagc ggccaacgtc atttcctttg aactgctgaa 2953861 ggaaaatgcg ctgaagcagt tcagccggcg ggcccgcaat gagtttttca acaattttat 2953921 tgagcggacc ttttcttcag atgacgaaat caaaaaccgg gcgaaagaat tcaagctgcg 2953981 ctgggatcaa aaatacatgt gcatcgccgg caaactcgat cgcaatgacg aatcaatcag 2954041 ctttacagaa aatcagctcg cttccgacag cgtattcgaa tttcttgaag gtgaattatc 2954101 agccttcccg tttccacctc acttctttat gaaaggaaat gtcggcatta ttctaatcga 2954161 ggcgacagac agctggagtg aaatgcacgc ctcggtgatc agctttttag aacagtttca 2954221 aacacaggtc agcgctcaat ttaaacgaac cgtgtccttt ggcatcagca atatctgcca 2954281 aaagctcatt gatgttcccg acgctttcac agaagcttct gatgctctgc aatcggggca 2954341 tttgtcaaga agcaccgcat ttatccaggt gtatcacgcc aaagatgtgc ctgagcttct 2954401 gcgcttgctc ccagttgagg atttgaagaa attttacaac tccacgcttc agagcctcgc 2954461 tgaaaaacag caggaggatc aaagcctgct tcatacgctt tccgtctatt tagagacaca 2954521 ctgccaaatt tcagagacgg caaagcgtct gtacgttcat cgcaatacgg tcatataccg 2954581 ccttgaaaaa tgcgaagagc ttctggggaa aagcttaaaa gatcctgaaa caacgatgcg 2954641 tttgcggctt gcattacgta tgcagcggct gatcagctaa agtttgttac attttcttac 2954701 aaaacgaatc gtttttcgtc actttcagca atcacacctg tctttttcag ctactgtatc 2954761 caatgacacc cctcgaccgg aacgatatta tgttactaaa gttcacatac agggagggac 2954821 tatagtgaaa aaaagatcgt ttaaggtgtt tacacttagc ctgcagcatg tgctcgccat 2954881 gtatgcaggt gcgattttgg tgcccctgct tgtcggcagg gcgctgaatg taacaactga 2954941 acagctgtcc tacctattgg cgattgacct gttaacatgc ggcgtcgcta cgcttttgca 2955001 aaccttgcgc ggaacataca tcggcatcgg gcttcccgtc atgcttggca gttcatttgt 2955061 ggccgtcacc ccaatgattg caatcggcag caattacggc attcacgcga tttatggttc 2955121 catcattgcg gccggtgtgt tcatcttttt gtttgcgcgt tttttcggca agctgactgt 2955181 gttatttcct cctgtcgtaa caggtaccgt tgtgaccttg atcggccttt cacttgttcc 2955241 gacaggtgtg aaaaatatgg ctggcggcga aaaaataaac ggcagcgcca accccgaata 2955301 cggttcgctc gaaaaccttc ttctctctgt cggtgtcctt gttctgatct tagtcctcaa 2955361 ccgctttctc aaaggatttg cccgaacact gtccgttctg atcggcatcg ccgccggaac 2955421 agcggcagca gcgatcatgg gcaaagtcag cttttcttct gttacagaag caccgttctt 2955481 ccaaatcccg aagccttttt acttcggagc ccctgcgttt gaaatcggtc cgatcttaac 2955541 gatgctgatc gtcggaatcg tcattattgt ggaatcaacc ggcgtttttt acgcaatcgg 2955601 aaagatatgc ggcagacctt taactgacaa agatctcgtc aaaggctatc gagcggaagg 2955661 aatcgccatt ctcatcggcg ggctgttcaa tgcctttcct tataatacct ttgcgcaaaa 2955721 cgccggctta ttgcagctga ccaaagtgaa aacaagaaac atcgtcgtta ccgcaggctg 2955781 tatccttgtc tgtctcggac tgattccgaa gattgccgcc cttgcatctg ccgttcctgc 2955841 tgctgtactt ggcggcgcga ccgtcgtcat gttcggcatg gtgattgcct ccggcgtcaa 2955901 aatgctcagc acagcggatc tcaaaaatca ataccacctc ctgaccatcg catgctcaat 2955961 cgcactcggc atcggcgcca gcacggcccc cgggattttt gctgaattcc ccgctccgat 2956021 ccggattctg gtcagtgacg gcaccatcac cggaagccta accgccatct ttttgaatct 2956081 atttttcagc ttgcgcgaca aaaaagaatt aacagcacag caaacagaac ttccggtatt 2956141 agaacataca ctcgcattag aaaaagaggt gtaaaaaaga tgaaggaaca gcacaatgcc 2956201 ttacagctaa tgatgctggg gcttcagcac atgcttgcca tgtatgcggg agccattctc 2956261 gttccgttga tcgtcggagc agcgatcggg ctgaatgcgg ggcagctgac gtatttaatc 2956321 gcgattgatt tgtttatgtg cggggcggca actcttttgc agctctggag aaaccgatat 2956381 ttcggcatcg gccttcccgt tgtgctcgga tgcacgttta ccgcagtcgg cccgatgatt 2956441 tccatcggaa gcacttacgg tgtcccagcg atatatggtg ccattatcgc cgcaggactg 2956501 attgtcgtct tagccgcggg cttcttcggg aagcttgtcc gtttttttcc gcctgtcgta 2956561 accggatcag tcgtcatgat catcggcatc agcctgattc caacggcaat gaataacctg 2956621 gccggaggtg aaggaagcaa agaattcggc tcactcgaca acgtgctcct cgggtttggc 2956681 gtcacagctt ttatcttatt gctgttttat ttctttaaag gctttatccg ctccatagcg 2956741 attttactcg gtcttatcgc aggaacagcg gctgcatatt tcatgggaaa ggtcgatttt 2956801 tctgaggttt tggaggcgtc ttggcttcat gttccgtctc tgttttattt cggaccgcca 2956861 acctttgagc tgccggctgt tgtcacgatg cttctcgttg caattgtcag cctcgttgaa 2956921 tcgacaggcg tttattttgc cctcgctgat atcacaaacc gcaggctgtc ggagaaggat 2956981 ctggaaaaag gctaccgggc agaaggcctt gcgattttgc tgggcggctt atttaacgcg 2957041 tttccctata cagctttctc gcagaatgtc ggcatcgttc agctctcaaa gatgaaaagt 2957101 gtcaacgtca tcgccatcac aggaatcata ctggtcgcga tcgggctggt tccaaaagca 2957161 gcggccctga caacagtgat ccccacccca gttctcggcg gcgcaatgat cgtcatgttc 2957221 ggcatggtca tttcttacgg gatcaaaatg ctatccagcg ttgaccttga ttcgcaaggc 2957281 aacctgctga ttatcgcctc ttccgtcagc ttggggcttg gcgctacaac agttcccgcg 2957341 ttgttttcat ctctttcggg cgcggcctct gtcttggcag gaagcggaat tgtgatcggc 2957401 agtttgacgg ccattgcact gcacgctttt tttcaaacca aacagccgaa tagcgcagac 2957461 ataaaaacgt aaaggaagat gccaatgttc acaatggatg acctgaacca aatggacaca 2957521 caaacactga cagacacact tggctctatt tttgaacact cttcatggat tgcggagaga 2957581 tccgcagcac tacggccgtt ttcgtccctt tctgatcttc accgcaaaat gactggcatt 2957641 gtaaaagctg cggatcgcga gacacagctt gatttaatca aaaagcatcc ccggctcgga 2957701 acaaagaaaa caatgagcga tgactcggta cgagagcagc agaacgcagg gctcggcaaa 2957761 ttagaacagc aggaatacga ggagtttctc atgctgaatg aacactatta tgatcgcttc 2957821 ggctttcctt ttattttagc ggtgaaggga aagacgaaac aggacattca ccaagccctg 2957881 ctggcaaggc ttgagagcga acgagaaacg gagttccagc aggcccttat agaaatttac 2957941 cgaatcgccc gctttcgtct ggctgacatc atcactgaaa aaggagagac gcaaatgaaa 2958001 agaaccatgt cttatggcaa aggaaatgta tttgcatacc gaacgtattt aaaaccgctc 2958061 actggagtga agcaaatccc ggaatcatct tttgccggaa gagataatac cgttgtcggc 2958121 gttgatgtga catgcgaaat tggcggagaa gccttcctgc catcatttac agacggagac 2958181 aacactctcg tcgtggcaac ggattcaatg aaaaacttta tccagcgcca tctcgcatcc 2958241 tatgaaggaa cgacaaccga ggggttccta cactatgtag ctcaccgatt tttagatacc 2958301 tattctcata tggacacgat cactctgact ggcgaagaca ttccgtttga agcaatgcct 2958361 gcatacgagg agaaagagct cagcacaagc cgcctcgtct tcagaagatc gcgtaatgaa 2958421 cgaagccgct ctgtgctgaa agcagaacga agcgggaata ccataacgat tacagagcaa 2958481 tacagcgaaa tcatggatct tcagctcgtc aaggtgagcg gcaactcctt cgtcggcttc 2958541 atccgggacg aatatacgac tctcccggaa gacggcaacc gcccgctgtt tgtctattta 2958601 aacatcagct ggcaatatga aaatacaaat gactcatacg cttctgatcc agcacgctac 2958661 gttgcggctg aacaagtccg cgacttagcg agcaccgttt ttcacgagct cgaaacccct 2958721 tcaatccaaa acctaatcta tcatatcggc tgcagaatat tagcgaggtt cccgcagctc 2958781 actgatgtca gcttccaatc tcaaaatcac acgtgggata cggttgtcga agaaatcccg 2958841 ggctcaaaag gaaaagtcta caccgaaccg cgcccgccat acggtttcca acattttacc 2958901 gtgacaagag aagacgccga gaaagaaaaa cagaaagccg ctgaaaaatg tcggagcctg 2958961 aaagcctgat gggaaaactg acaacccata ttttagattt aacctgcggc aaaccagcgg 2959021 cgaacgtaaa aattggattg aagcggctgg gcgaaagtat tatgaaagag gtatacacta 2959081 acaatgacgg cagggtcgat gtccctctgc tggctggtga agagctgatg tcaggagagt 2959141 atgtgatgga atttcatgca ggagactatt ttgcgagtaa aaacatgaac gcagccgatc 2959201 agccgttttt aaccatcgtc accgtccgtt ttcagctagc agatccagat gcacattatc 2959261 atatcccgct cttgctgtcg ccgtttggtt atcaggtgta tagggggagt taagaaggaa 2959321 gcccgcctca ccggcgggct tctttttgca cttcaattaa cttttgatcc taggacagta 2959381 cttgaagtga tccccacact tagtgaaaca acagctagaa taaacattca cctatatttt 2959441 tcaggataat tgcctacgag aaaaataccc tgtagtcctt tcatttataa atcgaggttt 2959501 caaactaata agtcagctct tagcagccga gctcccttct ccaatcctat aaacagaccg 2959561 cgttttttct cgaaaaaata ctctgaagac aattgctgcg tttttaatag ttttgataac 2959621 gcgttctctc ttacaccttt agacaaaata ttcatttttt cttttttaga cttaaatcta 2959681 tgtcgaaaat aatcgttggc atatcttatc ctatctccac taaaggaggt gacattatgg 2959741 gattctacaa ttctggtgga tacagtggaa actctggtta ctcaaacggt ttcgggagct 2959801 ccttcgcttt gatcgtggtg ctattcattt tgttgatcat tgttggagca gctatcttta 2959861 attattaagt ttaactttcc ttgcctccgc cgtatccaac acctccctgt ccgacagacg 2959921 ccataagaag tttttatggc gtctttgcta tgtgttcact aatctttttg taatccagaa 2959981 gctgtcaagt tctacgagat ttatcgtgtg ttttcccaca acgcttctgc gtcttgatcg 2960041 cgctgtctga ctgaggctaa aaaagtccgg cttttaaaag ccggactccc gtctaccccc 2960101 gttcaactct cttctaatcc tgcaagctga ccgcataatc ccgccatacc cggtacaccg 2960161 gcacaaattc cccgccagcc cttcttctat atctttgtca gaaggttgag gggtttcccg 2960221 aaacaatgct ttaagcgcaa tgatcattcc cggcgtacag tagccgcatt ggaagccgcc 2960281 ttcttccagg aaagcggttt gacacatatc cagctcttct ttttgaagcc cctcgatggt 2960341 tgtgatggaa tggccgtctg cttgataggc catcgtcatg cacgcattgg ccagttttcc 2960401 gtcgattaaa atagagcagg ctccgcagcg gccgattccg caggacacct ttgtcccggt 2960461 cagctgaaat tcctttctaa gcaggtcact cagatgtgtc gtaggaacgg cagcaacctc 2960521 ccacgcctga ccattcacgg tcatccggaa ctgttccttt tttacaggaa atggcccggc 2960581 ctcttttatg tccattgctt cagccccttt ctgtcgatcg cttcaagcaa ctcttctctt 2960641 gaaattggca gcttgtttat ccagcatccg accgcatcat gtactgcctt tacaatcgcc 2960701 ggagtgatgg cgattgttcc gatttcacca acaccgcgcg gtccatatac gtctcccttc 2960761 attaagtctt ctattgcaat cagcttcatg tcaggaacat ctttgattcc gggaatcaaa 2960821 tagtgatcga gattttccgc agcataacgg ccatccgtca ttttcgcttc ctccatcagt 2960881 gtgtagccga gtgccatggc agcgccgcct tcaatttgac ctcgatatcc ctgcggactg 2960941 acaaccggac ctgccgcaat agcgtgctca caatctatca atttgacatc gcctgttaac 2961001 agatctacct ccacctcaac ggcagccgct ccaaatgagt agaggaaatg gccgcccacc 2961061 acaggatcag gcgttgttgg aaagtcaaag gccgtttcct ctgccaaagg gcctttttca 2961121 gccagctcct tatacgtcac cacgagcgcc tttgtgtttt tgtcacgcaa gcctgcagcg 2961181 ccgggaataa gattttccgc tgaacagccg ctccattctg ccgcccgttt tttcaactga 2961241 gctagaaacg gcttcttcaa acgctggatc gcgtgccaca ccatgcttgt gccgcgggat 2961301 gctgtggagg agcctgactt cggcactttt gcggtatccc caataacaat ggaaatatcc 2961361 tctgcggcac aacccagctc ctccatgaca atctgttcaa tcgctgctag aatcccctgt 2961421 ccgcattctt caaatccaaa cgaagcagtg attttgcctt cactcgaaag agacaaacgg 2961481 cctcctgccg catccattcg gccaaacccc agcccgccgc cgtgcattgt aattgccgct 2961541 cccgtgcctc tttgcagata cccgcagttc cggcttgttt ttttaagaat gggagattta 2961601 gatatggcat tcaacacctg tgccgctccg tcagttggtg caattcgatg ctcaagcggc 2961661 cccaagtcat gcggttttct gatatttttt cttctcagct cgagcgggtc gatgccaagc 2961721 atgccgctga gacgatcgag atgggtttcg agtgcaaatg tgatttggtt gccgccaaag 2961781 ccccgaaatt cccccgccac cccgttgttc gtaaatactg atattccttc agtccggata 2961841 ttcggaatac ggtacggccc cgcggcatgc tcgacagaaa aatcaagaac agccggtccg 2961901 agcgtagcgt aagcgcctgt gtccgccaca attttcacgt cgtgcgccaa tagatttccc 2961961 gaatgatctg cacccgtttt tatcgtaatc ttcatcggat ggcgcttaat gccagaacgt 2962021 acagattcct ttcgtgtctg atgaattttg acagggcgtc cgcttttcag ggccaaaagc 2962081 gcagcatacg gctgaatatt cagctcatcc ttccctccga acgagccgcc catcggactt 2962141 gacacaattc tgatcttctc ttcaggaata tcaaaaatac gggcaagctg gaaacggtct 2962201 ttatagccgt gctgggttcc tgcatacatc gtaaaacccc cgtcgtcttc cggaacggct 2962261 acacctccct ccgtttccat atacgtatgc atctgccgcg gcagctcata ggtttcttca 2962321 aagactgtgt cagatgcttg aaacccttct tccacatcac cgtttgaaaa aaatgcgcgg 2962381 tgcaggatat tcccgtcctc atgcagtctt tgcgcattcg gccgaagcgc tttttctggt 2962441 gaatccatga cttccagctc tttatactca acttgaatca gctccagcgc cgcttccgcg 2962501 atttcttccg tttccgcagc aactgcggcg atcgcatccc cgacataccg caccctgtcc 2962561 tcacataaaa ccggctgatc agggatgaca atgccaaatc ggtttaagcc gggaacgtct 2962621 ttatgtgtga cgacggcctg cacgccttcc attttctcag cttttatggt gcaaaccgac 2962681 acaatctctg catgaggata agcacttctc agcaccttgc catacagcat tcctggaaag 2962741 ctgagatcgg tcatatattt caattcccct gtgaccttac cccttccatc cggcctgact 2962801 cttgacggtt tgttgatgat catttattcc cctccctcag ccatcagctc tgccatgatg 2962861 acgttggcag cggctttttt tctgtatgcc gctgacataa aaacatctga ggaaaacggc 2962921 agctcatgga taagtgtttt gtacagctca tgcgggtccc accctggtgc catccatttc 2962981 gcttcgctgt ccaataatct cctaggagtg atatcggcat ggccagcggc gaggcgaatg 2963041 ctgccgtctt tcaaaaaacg tccagctgca acagcagccg ctccggtaaa agcctggcgc 2963101 cttccaagct tgtgataaaa tacacgctct ccctccgccc gcgggatgat gacacgcgtg 2963161 acgatagccg ttctaaagtc ttcctcactg agccaagcgc caagcggcag cctgattagc 2963221 tccttttgat atacgataag ctcagcacca agcacaagca gaagcggaat gaaatcaccg 2963281 attttactcg ctatgttgcc gccaatcgtg gcacggctgc gaatccccgg tgcagcgaca 2963341 gcggaagcag cgtcactgaa acagctaagc gctctcttaa tcaaagggtt ctttctgcat 2963401 tcattcagtg atgtgagccc cccgatcgac acgtgggtgt cactggtgct gatccctcgc 2963461 atttcgtcaa tcccttcaag gctgacaagg tgctgtttcg gtagagttcc tttgtcccac 2963521 tgaagctgaa ggagcgtgct tcccgatgcg gcacacacat ccggagcaag cttctctaaa 2963581 agcgaatagg cctcatcaag cgctgccggt ctccataatt gaatattcat ccttgctttt 2963641 gtcacttggc cgttcaagac atcgccctcc ttaccatgtc atattcctcg ggtgtatcaa 2963701 tatcgtccaa ctcaccgcta tcctttgcct ccaaaaccgc tcctgctcca agctgtccgc 2963761 ttttcaggag cctgcgagcc ccttcatctc cctttaatcc ctttacataa ggaaaacatg 2963821 tcgacgagaa gtagattggc ggggtgaacg cccctaaaaa cgatgacacg gcaaatgact 2963881 caggagccag agccacaagg gcattgagat gatcgacgga aagctgaggc tggtcggcta 2963941 acaaaatgac aatgccgtcc gcccccatgc tttctgcttt tctcaccccg ctgctgactg 2964001 aatgcccctg acccttttct gcgtcttggc aaacgtgcag gctccagcgt ttttgaaaag 2964061 gcggagcgtg atacggcgct cctatccact caagggaggc atgttctgtc cgctcgacga 2964121 ccagcacgtg atcaaggcgg gacgacagag cagttttcaa ggaaagtgag cctatgtttt 2964181 ctccttttag cggcaaagcc agcttgtttt gtcccattct tctgcttttg ccggcagcga 2964241 gaaacacgcc gatcagatag gggcttctca tacaaccgcc acccgttttc ttgtttgaat 2964301 gatttctgca actacactta ccgcaatttc ctcgggacct tccgcaccga ttttcagccc 2964361 gaccggactg taaaagtgag acggaggatg ttttccgctc agcagccgtt tcgtgcggtt 2964421 tgccgaaccc aacagtccaa tataatggag gttttgagaa aataagaagt tgatgatcgt 2964481 ttgatcgtgc tgataatgat gggttgccac aacagctgca tcatgcggaa aaaattgaaa 2964541 ttcgctaagc atttgttccg gaaaagcggt gatcagctga tccgcttttg gaaaaagaga 2964601 ggatgtacaa taagcgggcc gccaatccgt cacgataaca gaaaaccctg tgtcagccgc 2964661 caaattggcc agcggtacat tatccggtcc cgccccaaac agaatgagac gcggcttcgg 2964721 ttcaattcgc tgaataaaca tgttagtggt ttgatcgaaa tgcggtaaat gaagcgttga 2964781 aacagtacgt tgaatatctt gcagaggcgc gtccggccag ttcccaaaat gtccgttctc 2964841 cgtcagaaat aaataatggg aggattcaat ctttataacg gaagtgacag ctttgcctga 2964901 atgaaggcag tccctcactt tctcatagtg ccgccttttt tcctgagtga ttcgctctgc 2964961 atgaacatga ataatgccat tgcacccggc tcccatgccc caagaaagat cgtcctccga 2965021 ccgcatgtcg tagggaatca gcgttgatgt gagctgatcg cccagcgcac tgattctttg 2965081 gaatacatct tcttccacac acccgccgct cagcaagcca atccgtctgc cttttttctt 2965141 aaagagcata gaggcgcctg cttttcgata cgcggagcct tcaacttgaa caattgtcgc 2965201 cagtacagcc tcctcctggt cttccaggag cgcatctaac atcgtgtgaa aattccccaa 2965261 tgccgcatcc tcctctcgaa aattgccgtg agaaacaact agttcagcgt gattttatag 2965321 gtaacttgta taaagaatag acgatggaag aaaaaatgac tcatgatttg tcagaaaatg 2965381 aaacacatag aaagaggatt tgtaaaaaga gtcaaacgaa gaaaatcaga ttggagaaaa 2965441 cacgaaatca tatcgttaaa aagcttgcgg agttccgcaa gcttttcttt acaccgctgc 2965501 ctggcggcca gcgttttcat acacatccag cgctgcttgg agcgcttttc ctgcttcgat 2965561 tcctgcgtta tgtctgagaa gcacagcctc taacccggca agcacgaata gcacgttttc 2965621 ttttctgcag ctgtacccca tcgtgccgat cctccagatc ttccctgcaa gcgggccgaa 2965681 tgagctggcg atttcaatgc cgaattgtgc cagcagcatg tcacggacag actcgccgtc 2965741 aatgccgccg ggaatttcga cacaggtgac aacaggcatt ttgcagctgt catctccaaa 2965801 caatcttagc cccattgcct ttatccctgc tgctaatgcg gcttcatggt gccgatgccg 2965861 ctcgaaacgc gtctcaagac cttcttcaag caccagtctg actccctcac gtaaggcgta 2965921 cagcatcgtc gtcgcttctg tatgatgatt gagccgtctt tcgctccaat aatcctcaag 2965981 ctggctcaaa tcaaagtagt tgcttgtaat tggccgattt cccgaaagtg ctgccctgtc 2966041 agcttgtgtc gcaatcccgc gttccacctt tttgcgagct gcaatcacgt ccgccacccg 2966101 ctcattatat gtaatcggcg ccattcctga aggcacagac aaacattttt gcgttccgcc 2966161 gatggcagcg tcaatcttcc attcatcgac tttaacctcg cagcccccaa tcgttgcgac 2966221 tgcatcgacg ataaacaatg catcctcggt gcggcaggct tcgccgatgg ctttcagcgg 2966281 gtgaatccgt cctgtcgatg tttctccatg caccatggcc acaattttcg gcttcacttt 2966341 ttttatctcc cgtatgatgt cctccgggtc aaaaaccgtt ccccattcgc actccagcat 2966401 atgaacattt gccccatatc gctcggcgat ttcagtcagc aaataaccga aacggccgta 2966461 aatgggaatg agcacatcat cttccggctc tatcacacta gccagcactg cttcaattcc 2966521 cgcccgtgaa gtgccgtcaa tcgggtatgc ccagcggttt tttgtttgga acagctcccg 2966581 aagcatctcc atcgtttcat tcataatacc tgtaaacgcc ggatcaaatt ggccgacaac 2966641 cggggtgctc attactctta atacacgcgg atcaacctca acaggccccg gtgtcataat 2966701 cgttcttaac ggggtgcata attctcttct gcctgacaca gccattcctc ctttatcagt 2966761 aagccagttt gtataataaa tcagtcagtg cgcggacgcc gatctcaagc tgtctggctg 2966821 acgtatattc cttcggtgag tggctgacgc cgcctcggct cggcacaaac agcatacaag 2966881 caggatagcg ccttccgatc atttgcgcgt catgccctgc tccgctcacc atttcctcac 2966941 agctgaagcc gttttctaat gctgtttcaa aagccgcagc cttcagcctt tcgtccatcg 2967001 gcacaggctc tatccgcata tattcatcaa tcacagcgcg aattcctttt tgtaggcaaa 2967061 tgccgttgat caaagcaacc atgtcttgat gaaactgttc cagcacatgc tgatgctgat 2967121 ggcgaatatc gattgaaaac tggacgcggc ccggtatgac attggctaca ttgggctctg 2967181 ccgttatttt tccgcatgtc agacggagct catccggcag ctcatccgac cgcagcagca 2967241 gctcatgaat gatacggctg ctggctgcga gcgggtcctt gcgccatttc atggaggtgg 2967301 ttcctgcgtg attgcattct ccttcgagcg tgacgagata tcgtctctgc cccgcaatac 2967361 ttgtcacgat gccgagatcc cggcctgaca tttccaacgt cttcccctgt tcaatatgca 2967421 gctcaacaaa cgcgctgata tctgtcctat atgctgactg aaacacacct ttgccaaaac 2967481 cgctctcatg catcgctgtt tggagggaga ctcccgactc gtctcttggc tcttttgcat 2967541 cttgttctga aaaaacaccc gtcatattcc ccgaccccca ataggtcatt ggaaaacggc 2967601 tgccttcctc ctcacataag gagaccgcct cgagcgtttt ttttggcgct ccgtatgttt 2967661 ccttgagctg ctttaacgcg agcattgccg ccagaacgcc ataggcgccg tcgtattttc 2967721 ctccattgat gacagtatcg atatgtgaac cggttacaat gacttcatcc ggagactggg 2967781 tgcccgaaag ccttccaaac acattgccga catcgtcgaa tcttgtttca agcccgaaag 2967841 aagacatttc cgttttcaca gcaagctgtg cgtccatcca ctcttttgtg tataaaagcc 2967901 tcgttacgcc gccatccgca gacgcaccgt attgggcgag ccattcaata taatctgtga 2967961 tgctgttttt tactgaaagc ttctgctttt ccatgtactc ccccctctgg ccgctatggt 2968021 gacttcatta tagaaggagc aacatgatag ttcattgaca gattaaccaa aaaaacgttt 2968081 attttttagc cacagtatcc atccagcaac cagatacacc ctacatgtca caactatttt 2968141 gatgtaaagg tcaaaagaaa acacggtaag gaagagagcc agcaagagcg aaagagaggg 2968201 tcaaaatgcc tttcatatga acaagctaag ctggagaggc gatgttcgcg gaacggatga 2968261 aaacagaaat gccggcagcc cgcaaaaaca ggacctaaag atatggaaac aggagatttc 2968321 cgcctcctcc aaagggacta atttacaatt ttaatgaaaa atatacaaaa tgacacttct 2968381 atcctttatt tcaattttag ataatagata tgatctgata aaaggagggc aagtgatgac 2968441 aaaaaaagca tggtttctgc cgctcgtctg tgtattactg atttccggat ggcttgcgcc 2968501 agcagcttca gcaagcgcgc aaaccacatt aagccttaat gaccgattgg cgtcttcccc 2968561 ttcaggaacg ggaagccttc tctcattagc cgcccccgct gcaccctatg ctgacacaga 2968621 tacctattat gaaggggctg aaggtaaaac aggagactcg ctaaaaagca ccctgcaccg 2968681 tattatcagc ggacacacga tgctgtccta cagcgaagtg tggaacgcgc tgaaagaaac 2968741 ggatgaagac ccaagaaatc cgaataacgt catcctgctc tatacgaatg aatcgcgttc 2968801 caaaaacctg aacggcggca atgtcggcga ttggaaccgc gagcatgtct gggcgaaatc 2968861 ccatggcgat tttggtacga gcaagggacc tggtactgat attcatcatt tgcgcccggc 2968921 tgatgttcaa gttaacagcg ccagaggaaa tatggatttt gacaatggcg gcactgaata 2968981 tgcgaaggca cccggaaatt attatgacgg cgattcatgg gagccccgcg atgatgtgaa 2969041 aggcgatgtt gcccgcatgc tgttttacat ggctgtccgt tacgagggtg atgacggcta 2969101 tcctgatctt gagcttaatg ataagacagg caacggctca gctccttatc atggcaaaca 2969161 atctgtcctg ctcgaatgga ataagcagga tccggttgac gaccgcgagc ggaaaagaaa 2969221 tgaaatcatt tatgaaaaat atcagcacaa ccgcaatcca tttatcgacc accctgaatg 2969281 ggcggatgag atttggccgt aagaaaaagg tgctcctttt gaggagcacc tttttctaat 2969341 acacagcctc ttccgtttcc gcatcgaaaa agacgacgtg gtccattttc actgagagct 2969401 ggattgaatc gcctgcatcg attcgcgtgt ttccgtccag gcggaccttg agccgctcgt 2969461 ccccagccat gacatgcact atgagctccg agcccagatt ttcattcact tccacgttcg 2969521 cttgaaacac tgaatcaaac aactggtcat ttcctgtcat ttgtgtgatg tgctccggcc 2969581 gtacaccggc aatcatctgt tctccggcat atcccttttc cttcagccgc tttgcttttt 2969641 cttcaggaat atgaagccgg atcgaagaat ttgtgaaaaa cagctcgcca tgctgctgtt 2969701 ctatgatgcc tttcaaaaag ttcattccgg gagagccaat gaagcctgcg acaaacaaat 2969761 tggccgggta atgataaatg tcatgaggtt tcgccacttg ctgaatttcc ccttcattca 2969821 tgacgacaat ccgatctccc attgtcattg cttcggtctg gtcatgcgtg acataaatga 2969881 tcgttgcctc taatcgctgg tgcagcttgc tgatttctgt ccgcatcgtc actcttagtt 2969941 ttgcatccag attagaaagc ggctcgtcca ttaaaaagac cttcggctcc ctcacaatcg 2970001 acctgccaag cgccaccctt tgccgctgcc cgccggagag cgccttcggt tttctcttca 2970061 gcaaatgttc aatttctaaa attctggctg ccgcatgaac ccgctcggca atttcctgtt 2970121 tcgccatctt tctgagcttt aatccaaacg ccatattatc aaaaaccgtc atatgcggat 2970181 aaagcgcata gttctggaat accatcgcaa tatcacgttc tttcggcgga agatcattga 2970241 cccgctcccc atcaataaga agatttcctt cagaaatgct ttctaatcca gccaccatcc 2970301 gcagcgttgt tgattttccg catcctgacg gccccaccag caccaaaagc tccttatcct 2970361 ttacatctaa atcaaagtcc ttcacggtta attgtgagtg atatgatttt ttgacgtgtt 2970421 caaatgttaa tgaagccatc agaaaagtcc ccctatcttt tgacccgtta tttcgtcact 2970481 ggaaacaact tggtctttct gttattttta gagtaatcga ttcccatttt tgctatattt 2970541 ctaaaataaa aaatgtaaat ttgtattata acgtcataat acattataat ataaataata 2970601 ggttaaaagg aggctaccct ttgttaaaca acggaagttc tacaccttta tacattcagc 2970661 taaaacaaat catcactgat gacatcaaaa agggcgtgta ttccccaacc gccaagctgc 2970721 ctaccgaaaa cgagctttgc accaagtata acgtcagccg catcaccgtc aggaaagcca 2970781 ttctcgattt agtcgaagaa ggctatctga tcaggcagca gggaaaggga acgttcgtta 2970841 aaagccctaa attaaaacga gagctgatcg ctgtaaacgg ctactcggaa tttatggaat 2970901 caaccggcaa aaaaccgaag catcatgtgc tgtcccatga catcattcca gcgtcaaaac 2970961 ccatcgccga aaagcttcaa atccaacccg agagccctgt ggttgaatta aaacggattt 2971021 tatataatga tgatcagcct ctcacctttg aagtgacgca ttatccgctt gatttgtttc 2971081 ccggcattga tacctttatt gctgacggcg tctccatgca tgatattttg aaacagcaat 2971141 acaaagttgt acccacgcac aatacgaagc tattaaacgt tgtatatgcc caacaggagg 2971201 aaagcaaata cctggattgt gatatcgggg atgcgctgtt tgaaattgat aaaacggctt 2971261 ttacatcaaa cgaccagcca atctattgct cattgttttt gatgcacaca aaccgtgtca 2971321 cttttaccat caacagcccc tacacataac aggcataaaa aacgagacac tgcttatagt 2971381 attctcgttt tttcactgct tcccccgtcc tccaagcgat aaggatagcc atagccgaaa 2971441 gctccgtaca caccgcaagt tttcgcagcc gtttcagcag cctggcgcaa agcatacgtt 2971501 atatcctgct tcacgcaaaa ggcagtcaaa aagcctgcta taaaagaatc tcccgctcca 2971561 agtgtatcta ttatatcagc ttccacaatc ggctgatgat agactcgatc acccgcagac 2971621 aggattgctc cttggccccc tcgggtcata caaaccattt tggctccgta cccatgagct 2971681 gttttggcaa gctcaccgca ttccgactca ctcaaatcgc ttcctgaaaa aaacgcatac 2971741 gtcacataag gacagaccct cctcaaataa tcatcctccc gattggttga aaaatcaaat 2971801 gagaccggga ccagcccgca cagctgcgga agatcgttct caagcctgct gtacacgctc 2971861 gtatgcagca gatcatgccc gctgataaaa gatacatctt tctcctgaaa cgcgaggcga 2971921 agccgggact gaatgccgcc tttatttgat ctgacaaaaa tgcggtcccc ctgttcatca 2971981 agggtgacaa tcgccatccc gttttctccg tgcgcctggc ggatataatc tgcattgacc 2972041 tgctccagct tgagaacgtt caacagatgc gccgcggctt cgtcattgcc gacgattccg 2972101 atataggaag actcatgccc gagccgcttg gcaagcacag caacgtttaa ggcatttcct 2972161 cccgggtaaa atgtttcttg atcctggtag taatctacaa cattatctcc aaccgcaatc 2972221 aatttcatag cgcttcctcc tttatccttt tacactgccg cttgcaatcc cgcggacaaa 2972281 atatttctgc atcaataaaa atagaataat aatcggcgcg gctgaaatcg ttaaccccgc 2972341 cagcaggacg ccccagtctg tctgcagcgc gtctctgaac tgcatcagcc cggctggaat 2972401 ggtccgtaaa ttctcatcat ctatgaaaat aatcgcaaac ataaactcat tccatgtatg 2972461 gtaagccgtc aaaatgccgg atgtcaccaa aatcggcacg ctcattggta agaaaattct 2972521 gaaaaatact ccaaaacttg tacacccatc caaataggcc gcctcctcca attcttttga 2972581 aatagaaaga aaataagagc ggatcaaaat gatggtgaat gggatccgat aagccgcata 2972641 cggcaagatt aacgcccaat acgtattgta caggcccagc gactgaataa tagaataaag 2972701 cggcacaaga ctgacctgcg gcgtcagcat caatccgcca agacatagca ccaaaaagaa 2972761 tccttttcct ttaaactcaa accgggaaag gccatacgct gcccatgcac tgataaagac 2972821 agtgatcaca cacgtcagcg ccgtaacgat gacactgttc ataaaataag aagaaatccc 2972881 ctgattccag gcggaaacaa aattttccgg atgccacgaa gacggcagcg accagctgtg 2972941 ctcaaaaata tcgtcagagt ttttaaaggc gctcatcacc atccagagaa gcggataggc 2973001 aatcgcaatc agataaagaa acagaaaaac ccacacagac gtttctccga tataccattt 2973061 tcgtctaggc ttatctttca cctcaatgtg ctggtcaggc accggctcca atctgaacga 2973121 atctgtcttc ttctgaggca gcatcagtta ctcctccttt ccggttttaa agaacttcat 2973181 ttgcatgagc gataatgcaa gcgtaatgat taacacgaca gtggcaatcg ctgaggcgta 2973241 gcccatcata tcctttgtaa aggcgctttt atataaaaac gtgctcaaga cttctgacgc 2973301 ttttcccggc ccgccgcctg tcaaaatgta cggctcatta aagaccgtaa aggctccggt 2973361 cagcgtcatg accaccgcaa caaaagacat ctctttcgtc tggggaacag taatatgaaa 2973421 aaactgctga attttacccg cgccgtcaag ccgggccgct tcatacagtt catccggtat 2973481 tttttgaatc gacacgatgt acagcatcgc aatataaccg acagattgcc actgggacac 2973541 aaaaatgaca gaaagcatag ctgtgctgtc atccccgagc caggccctcg tcagctgatc 2973601 aagaccgatg gcctgaagca gctgattcaa aagccctgtc tccggattgt aaataaaatc 2973661 aaacaaaagc gcgatcaccg tcattgagat gacaaccggc aaaaagaaaa cggtacgaaa 2973721 aaacggcgac cattttctga ccagcttatc ctcaagcacc gccgccaaaa tcaaaccgcc 2973781 aaatacctgg catacaattg agatcactgc ataaagcaca ttattggtaa gtgcctgata 2973841 gaagacagga tcatgaaata attcaacata gttttttaag ccgataaacg ttttttccgg 2973901 agaaaatgag ctccactgaa acaggctgag gaatacattc tcaaaaatcg ggatataaac 2973961 gaaaagtaaa aaaacgagag cgggcaccaa aaacaaatag gggattattt tattctgatt 2974021 gaccaagggt atctcatctc ctttataaaa agaaaaggtg cgaagcttca ccttttcttt 2974081 gatttattca gctgacgccc tcacctgctt tgctgccttt tgaacggctt tcatcacctg 2974141 ctgcggtgtc atgtcgccgc caagcatttg ctggacgccc gttaggtacg catctgcgac 2974201 ttcaacatcg acatccatat caaaccatgg aaccattgat ttggcatcaa caatatgctg 2974261 aacggcttca cgctgaatgg ctgttgcatt ttcttcagta gccgtacctt gcactgcact 2974321 gtatttcccg acatctttca cgagcttttc gcccattctt ttcgacgtca agaactgcaa 2974381 aaattccatc gcttccttcg gatgttttgt tcttgaggag atcatgaatc cttccggcgc 2974441 tcccgttaac gcttctgaag atcctttctg cccgctgatt tcaggaaatg ggaacatccc 2974501 gagattaacc ggttcaacca gcttgatttc cgctgtttcc gcatatatca tcgccgactt 2974561 tccgctctta aattgctgtc tcacatattc gtggtcgacg gagtttacat gtttattaaa 2974621 gtaaggcatc agctcttgaa gcttttcaag tgcttttacg tagccttcat cagtaaattc 2974681 acccgttttg gcgttatagt ccttttcccg tgttttttca tcgaccatcc gctgattaag 2974741 cgtgccgata tagtgcgaga ttgtccaagt cgcctttgtt ccaaagctga tcggtgtgta 2974801 gccatgttct ttcagctttt ttgacacatc gattaattca tcccacgtct tcgggggatc 2974861 aagattcagc ttttggaaaa tgtctttatt atagaagaat gatttagcgt ccatttgcca 2974921 cggtacgcca tattgcttgt tttcataagt aaatggtgta atttgcgatt gaacgagctg 2974981 tgatgaccaa tcggtgtcat ttttgtagta ggacgagaga tcaagtgctt tattgcctct 2975041 gataaattta aaagcaaact catcgctcca agagaagtaa atgtcaggag ggctggtggt 2975101 tcccagcatg accttaattt tatctttata ggagtcattt aaaacggctt caatttgaat 2975161 gtcgatatct gggtgatctt tttcaaattc cttaacaacc tcttcaaaat aacttttttc 2975221 cggctccttt ggccatctgt ggaaaaattt caatgtcacc tttccgtccg ctgaactgct 2975281 ttggctcgaa cagcctgcga tggtgagcat actgacagct gcaatgatca agaacaacaa 2975341 cattttcttc aaagggttgg cctcctctgg acattagact ataatgttat ataacattat 2975401 agtctaatgc ataatggttc ttcattttca gatcaatact caactttcca catgtatctt 2975461 ctatgagata aaggatgatt tctctcctct gccagctcgt ctgcatagct tctcagcaca 2975521 cgattgagaa cgagcggagc aagatagcct ttaactgaat cgtcaattgc agtgaagtcg 2975581 taagatgcag catcaagcac agtgagcttt ttgccatact ttttcgagaa ggtaagcgcc 2975641 cgctcttcaa gaggtcttgt ttcatctaaa ccgagcagga tgataaacgg cacggattca 2975701 tcaataattt caaacggtcc gtgaaaatat tctccggcat gaatggcgtg ggaatgaatc 2975761 cattgcattt ccatgagaat gcagatgctg taggagtaag cgacaccgta gtttgcaccg 2975821 cttgccatgg tataaataat gctttctttt tcatgggctt ttgcaaattg cttggcgttg 2975881 tcagcttcct gcttaagggc tttttcatat acagcctgca attgatctaa gccttcaatt 2975941 gcttgctcaa atttcgtatt gttttctaat acttgcaggg ttccaaaaac gatttgatac 2976001 aaaacgccat agtttgtatt gatcgcaagc gcctcatcac cccaatcgta ctgggcaaca 2976061 tattgcgctt cctgcgctaa aggagactcc ggtttaaacg tcatcgcaat cgtaagtgcg 2976121 cccttgcccc ttgcaaacgc agcagctttg actgtctccg gggtatttcc cgaatgcgag 2976181 cacaaaataa caagagactt ttcaccaagc tgaacagggt tgcgctgaat aaattcgttg 2976241 gcgctgtaga gatcggagtt tattgatttt gactctctgt caaacacata cttactcgga 2976301 tacataatgg cagaagaccc tccgcatgcg acaaagaata catgatcaat ggttttccct 2976361 ttcaaatcct gcaagaaagc ttgaacctca cgatttactt ttgctgtggc ctgactcaaa 2976421 tccttcactc ctcgttttta ttatataacg ttatataaca ttatatattg ttatattaaa 2976481 gtccgcgggt aggattgtca atattatttt ctgaaatttc tcaataattt attcggatga 2976541 cagacaaagg gtctatatgc gaaaaaatgc ccaaatcaaa agccagaact tgacttaagc 2976601 tctggcttcg ctgttcaatc cgcagactga cgtcttattt aaaaaatacc ttgtctatat 2976661 tgtacttcga gtgctgtgta ttgatgatat atgtttcgta aatctctctt tccattggat 2976721 catcaactac acatacctca attttataaa cttcatctct gtgatgtttg atcggtgaaa 2976781 cagtgtcttc gaaatgcttc ttaattctct gtcttaactt tctggcttta ccgacaaaca 2976841 gcagctcgtc atgaatgttg taaaacataa aaatgccgcc tttgtccctt gggatctggt 2976901 gaaagtcgat gaatccgtga atcggtttta tcttcggctc gttatcatta gctgactgct 2976961 gtcgttcagt gatggtgaca ttcggtgcgg gtatatcaat ttttatcaaa atcagttcac 2977021 gtcctctttt tcattaaaga taaatgctaa cacatacaga aaagaaaagc tagaacagct 2977081 ttattatatt tgtttgtcat gctcttactt attatgcaag tgctccggct ggatcataag 2977141 gactaaggtc taattctgtc tgctttccga gaactagctt tgcgagctct gcacccaaaa 2977201 acggccccat cgtcagtcca gaagcaccca aaccgtttgc agcgtacagg ccttgaacat 2977261 tcggcacggc ccctacgacc ggcagaaatc ccggtgtaaa cggcctgaag cccactcttg 2977321 tttcaacagc agccgcatca gcaagacccg gtgcaacggc taacgctttg ctcaatactt 2977381 cgtgctggcc tccggctgtc acacgaagat catcaagacc ggcatcgttt tcgtgtgtgg 2977441 cgccggctac aattctgccg ttatcaaacg acagaatgta ctgatcactc ggcggcatta 2977501 caaccggcca cgatcctgta tctgcatctg tcatttcaaa atgcataatc tgcgcttttt 2977561 gaaatgacac ttgaaaatga atgccaagag gcttcaatat ctcattggcc catgctcccg 2977621 ccgtcacaat gaccgcgtca gccgcaaact gctttgtatc tgtttgcacg ccggtgactg 2977681 ttccgttttc aaaaagcaag gacgcatttc ctttgatgac cgttgcgccg cgtttctctg 2977741 cagcgcttaa aagcgaccgg cacagcgctc ttccgttcac acgggcggca ccgctgatat 2977801 gaaccgattc atagccgtca gctaaaatcg gaaacagctt tttcgtttca cttgcagaca 2977861 agcgggtaat gtcgccgatt tccggcgcat cctcccgtct cttatacgcc ctttcctcca 2977921 ttttatcgag tttagacgcg tcagtatgaa tgctgatggc accgacacgt ttgtatcctg 2977981 tatccgattc accgtctttt tccaattgat ggattaaatc cttatagtac cgcgctcccc 2978041 ccttagcaag ctggtaccaa tcctgattac ggcgctgcga gagccaagga cagacgatcc 2978101 ccgccgccgc atcagtcgct tgtcccggct ctttccgatc aatgacagta acgcgagcgc 2978161 ctgtttttgc gagatgataa gccgtcgacg cgcccagaat ccctgcgccg acgatgatgt 2978221 acgatttcat atgcaaacac cttttctatt ataatgtcta ttcattttac caaatcaaat 2978281 gctttccttc gaccttttgc cctaatgtgg aaaaaccgcg aagttcgtcc aatctcttta 2978341 ctctcctatc gaatatcctg tcactatcaa tagagaaagg atgataccat gagcgaaaat 2978401 cgtcatgaaa atgaagaaaa cagacgcgat gcggcagtgg caaaagtcca aaacagcggt 2978461 aatgcaaaag tcgtggtcag cgtgaacaca gatcaggatc aggcacaggc gcagtcacaa 2978521 gacggagaag actaatgaac gaaaacatca ttcctcttaa cagacatact caagagatac 2978581 ccactactga atctgttatc aaaaacagcg gcaactcaga ggtccatatc gacattcaca 2978641 ttgatacaat gccaattgct tttgctatat tatgctctgc attagccgca aagcagatga 2978701 caaaagagga attcgatatg gcttatactc aattgcgaga gatgaacaga gaaaataaca 2978761 gcagatcatc tgtaaagcaa attatcaatc aagagacaga agaagagtaa aaaaccgcgg 2978821 cccctcggcc agcggttttt cttctgcata caaaaaggac gcgactgaat cggttacttc 2978881 tgtacaattt gaataaggtt accgcatgta tcgtcgaaga cagctattgt gacttcgccc 2978941 atttttgtcg gttccgtcgt aaacgtcacg cctttttcct ttaatcggtt gtactctttt 2979001 tgaatatctg caacgccaaa cattgtggcc gggaggcctt cggagaatat cttcttttga 2979061 tactccttgg cggcaggatg ttcattcggt tcgagtaaaa gctcggttcc gtcttgatca 2979121 tctggagaaa caagcgttat ccacctgaat ttccccatgg gaacgtcttc cttttttata 2979181 aacccaagtt tttctgtata aaactccagt gccatgtctt gatcttgtac aaatatactg 2979241 gtaacaacga ttttcatact gtttttccct ccttcgatat gaatgaagca tggtactatg 2979301 ctaacaatct ggctacaagc aaaacaaccc acacatttat cagaggccct gttctgattt 2979361 tataaaatta ttctatccat cctttcagca aatttttaag cggttcgttg ttgaatataa 2979421 gtactcgata ttttcccttt cgttttgatg ttacgagtcc tgcatcctcc agtacagaaa 2979481 ggtgtttagc tatcgcctgt cgcgtaatag aaaggtcgta ctttgtaata agacgtatcg 2979541 taagttcata caacgtcagc tcgttgcgtt cagataattc gtctaatata agccgccgag 2979601 tcgaatcgcc gagtgctttg aatatagcgt ctttgttccc attcatatat tgagtataag 2979661 caacccatta gttgcatgtc aagtataagc aactgtatgg ttgcgtgata tagaaactga 2979721 acctatccgg cgcaggtctg aaatattcta atcgataagg aattaaaacc attaaaataa 2979781 cagtggatat gtctctgaaa aataaaagaa gacgaacttc aaaagttcgt cttctacaat 2979841 caaattcggc acgccggcca ttttaaagtt gataactatc tctaaacccc ttgataaaca 2979901 aaggagtttt catcattaac cgatagaacc ttccatttcg aacttaatca aacggttcat 2979961 ttcaactgcg tattccatcg gaagctcttt tgtgaatggc tcgataaagc ccattacgat 2980021 catttcagtt gcttcttctt cagaaatacc gcggctcatc aagtagaaga gctgctcttc 2980081 agatacttta gacactttcg cttcgtgctc caatgaaatg ttatcattta agatttcatt 2980141 gtaaggaatt gtgtcagaag ttgatttgtt atccataatg agcgtatcac actcgatgtt 2980201 agagcgggcg ccttccgctt tgcgtccgaa gtggacgatt ccgcggtacg ttacttttcc 2980261 gccctgtttt gaaatcgatt ttgatacgat tgtagatgat gtgtttggtg caaggtgaat 2980321 cattttcgca cctgcatcct gatgctggcc tttacccgca agagcgatag aaagcgtcat 2980381 accgcgcgcg ccttcgcctt ttaggataca agccggatat ttcattgtca gcttagaacc 2980441 gatgttgccg tcgatccatt ccattgttgc gttttcttca cagactgtac gctttgttac 2980501 aaggttgtaa acgttgttcg cccagttttg gatcgttgta taacggcagt agccgccttt 2980561 tttcacgatg atctcaacga ccgcactgtg aagtgagttt gttgtgtaaa caggcgcagt 2980621 acagccttca acataatgaa cgcttgcttc ttcgtcaaca atgatcagtg tacgttcgaa 2980681 ctgacccatg ttctcagagt tgatacggaa gtaagcttgt agcggtgttt caaccttcac 2980741 gcctttaggc acgtagatga aagaaccgcc ggaccaaaca gctgagttaa gcgccgcaaa 2980801 cttgttatca gtcggcggga ttacttttgc ccagtgctca cggaaaatat cttcattctc 2980861 tttcagcgcg ctgtcagtgt ctttaaagac gatgccttgt gcttcaagat cttctttcat 2980921 gttgtggtat acaacctcag attcgtactg agcagaaaca cccgcaaggt atttttgttc 2980981 agcttcagga ataccgagct tgtcgaatgt ttgtttaatt tcttcaggaa cttcatccca 2981041 agaacgctct gaacgctcag acggttttac gtagtacgta atttcgtcaa agttcagtga 2981101 gtttaaatct ccgccccatt gaggcatcgg catattgtag aaatgctcaa gtgatttcaa 2981161 gcggaagtca agcatccatt gaggctcttc tttcatgcga gaaatttctt ctacgatttc 2981221 ttttgtcaat ccgcgctctg aacggaaaat ggaaacgtcc ttgtcgtgaa aaccatactt 2981281 gtattcacca atatcaggca tttttttagc catccatttt cactccaatc cttttaattg 2981341 ccgccttctt ctttcgcgac tcctttttca agtgctttcc atgacagggt tgcacatttg 2981401 atacgggcag ggaattttga aacgccttga agggcttcaa tatccccgag atctatagaa 2981461 tcatcatact ctttcccttg catcatatcc gagaaaatct tagacatgga aagggcagtt 2981521 tcaatatctt tccctttaat cgcctgagtc atcatcgaag cggatgccat tgaaatggaa 2981581 cagccttccc cttcaaactt cgcatcttcc acgatgtctc cgtcaagctt cattgtcagt 2981641 ctgatgcggt cgccgcatgt cggattgttc atatccacga caatgctgtc atttaaaacc 2981701 cctttatttc gcgggttttt gtaatgatcc ataatcacct gtctgtacaa tgtatctaag 2981761 tttgcattaa aagacatttg taaaatactc ctttgtcttt tgaagagctt ccacaagctt 2981821 atcaatctct tcctctgtat tatacagata aaagcttgct cttgcagtag cagttacatc 2981881 cagccatttc atcagcggct gcgcacaatg gtggccggct ctgactgcga ttccctccgc 2981941 atcaagcaca gtcgccacat cgtgcggatg aacatcatca aggttaaatg tgacaagccc 2982001 ggcacgctct tccggcccgt aaaccgttac gccgtcaagc tggcggaagc gttcaagcgc 2982061 ataagctgca agcttgtgct catggcggga aatctcatca agaccgattt cttcgagaaa 2982121 atcaatggcg gcaccgaggc cgattgctcc tgcaataatc ggcgtacccg cttcgaattt 2982181 ccacggaagc tctttccaag ttgattcata aagcccgaca aagtcgatca tttcaccgcc 2982241 gaattcggca ggctccatgt tttccagcag ggctttcttt ccgtacagca caccaacacc 2982301 ggtaggtccg cacattttat gggaagaaag cgcaaagaag tcgcaatcga gatcctgcac 2982361 gtcaattttc atgtgaggcg tgctttgtgc accgtccacc acaatgacag ccccattgtc 2982421 atgagcgatt ttcgccattt ctttaatcgg gttgaccgtg ccgagaacat tagatacatg 2982481 agacaccgca acaatttttg tgttgcttgt gaccgtttct ctgacgtctt ctaaagaaat 2982541 cgttccgtct tcctgcaacg gaatatattt taatgtggcg ccagttgctt ttacagcctg 2982601 ctgccacgga atgatattcg catgatgctc catgtaggtg atgaccactt catcaccagg 2982661 tttcaggttg gcgcgcgcat agcttaacgc caccatattc agtgatgtgg tcgtgccttt 2982721 tgtgaaaata atctcagcca ttgacttcgc gttaataaac ttgcggactt tttcacgcgc 2982781 tccttcataa ccatctgtcg ctctggttcc aagtgtatgg acgccccggt gaacattgga 2982841 attgtattgg ttataatact tatccagtgt ttcaatgaca gcacgcggct tctgggaagt 2982901 cgccgcgctg tcgagataaa cgagatcatg tccgttcact tgctgatgaa ggatcgggaa 2982961 ctgttcacga atatctgtga tattcattac ttcactttcc tttcgataac agaaactaat 2983021 tgtttcttaa cgccttcaat cggaagttca tttactaccg gtgcaaggaa tccgtaaatg 2983081 actaagcgtt ctgcttcttc tttcggaatt ccgcggctca tcaggtagta aagctgaata 2983141 gggtccacac ggccgacaga tgccgcatgt cctgcagtta catcgtcttc gtcaattaaa 2983201 agaatagggt ttgcgtctcc gcgtgctttt tcgctaagca tcagcacgcg tgattcttgc 2983261 tccgcattcg ctttagaagc gccatgttcg attttgccga ttccgttaaa gatagaagaa 2983321 gcggaatcct tcatcacacc gtgcttcaag atatagcctt cagaagcttt accgaaatgg 2983381 atgatttgtg ttgtgaagtt ttctgtttgc tctcctcttc cgacaacaac cgttttcgta 2983441 tcgccgtatg tgccgtcacc gtaaaggttt gttgtgtttt cggaaatcgt gtcgccatcg 2983501 ttcatcaggc cgagagccca ctcgattttg ctgtcgcgtc cgcgcgcagc accgcggcgg 2983561 ttcacataag ttgtcacacc gcttgacaga ttatccaccg caccgtatgt cacgctggca 2983621 ttatcacctg tgatgacctc actgataata ttgaagacag cgtctttcgg gtttacagtg 2983681 ctgatgtagt tttctacata tgttacagag ctgtggtctt cagccacaat cagcacgtgg 2983741 ttgaatagag ctgtatcatt gctttcgtgg acataaacag cctgaaccgg cgtctccacc 2983801 tgaacatttt tcggaacata aaggaatgct cctccgttaa caagagccgc gtgaagtgca 2983861 gttaacttat gttcgtcaac cttcacgccg tccttcataa agtatttctc caccaagtcg 2983921 ctgtgctcgc gtgcagcagt cagaatatca gtgaagatga cgcctttgtc tttcaattct 2983981 tgagaaagag aaagatgtgc cggcgtctgg tcacgctgta cgtataatgt tttatcttcg 2984041 ttttcaatgt cgatcagcgc ttttacttca tcagtcaaat cttctaatga agaaagcggt 2984101 tcgttatcca ctgtatgctt cgcgaaattc gtgaagttcc agtttgtgat ttttgttttg 2984161 tcaggtttcg gcatcggcag atcctcagct tgttcaagag cctgtaagcg caggttcttc 2984221 agccaggcag gttcttggtg cttttcggaa aagcttttga gatactcctg atctacggat 2984281 agttttgtac ctagtgtcat attaatcccc ctaacgctta cgcttcttgg ccaacagttt 2984341 cgtcttcaat gccaagttct tgtttgatcc agtcataacc ttctgcttca agacgctgtg 2984401 caagctctgc accgccggat tttacaacgc ggccttgcat cataacgtga acaacatccg 2984461 gagtgatgta gtttaacagg cgctgatagt gagtgatcat caggcagccg aagttttcgc 2984521 tgcgcatttt gttgatccct tttgatacaa ctttcaaagc gtcaatatca aggcctgagt 2984581 caatttcatc aaggatggcg attttcggtt caatcatcat taattgaagg atttcgttgc 2984641 gttttttctc cccgcctgag aagccttcgt taagatagcg ctgagccatt tcagggtcca 2984701 tttcaaggaa ctccatgttt tcgtccattt tgcggatgaa tttcatgaga gaaatttcat 2984761 cgccttcttc tctgcgcgcg ttgattgctg agcgaaggaa gtcggcattt gtcacaccgc 2984821 tgatttcact tgggtactgc attgcaagga ataagcctgc ctgcgcacgc tcgtccactt 2984881 ccatctccag tacatctttg ccgtcaagcg tgatgctgcc ttttgttact tcatatttag 2984941 gatgccccat aatagcagct gataaagtgg atttaccagt tccgttcggg cccattactg 2985001 cgtggaattc tccacctttt atttcaaggt ttacaccctt taagatctct ttcccttcga 2985061 tttcaacgtg aagatctttg atcgttaatg ttgaagcagc catatctata cctccaaaaa 2985121 tatataatca ttattctcat tttattctca ttctaatttt ataacaaatg aaaagtaaat 2985181 acaacttttt atcgtgcctt gcacattcct caagtttaac aaagatcagc actttattaa 2985241 agcgattgaa aaagaaaaag agtggattcc cacccttttt taaaagattg attttctcaa 2985301 taagctcccg cagaaatccg cttgcttttt tcataatcaa gctctctctg ccgctctact 2985361 ttcattcttg tttccagccg gcgtccatat tcctcgtatc caattccgtg tgacagctgc 2985421 atcgcttttt ccatttctga cgtataatcg aggttcagtc tgtcctggct gctgcaaata 2985481 atgaatcaat cccttcatat atttgctttt tattgtacca gtgctgcgtt ggatgccgca 2985541 aaaacgattt ggcgtgaaat agcggcagat gagacgaaag catcctttca gaacaaatga 2985601 gaatggtttt tcggaatatt ccttctctta atgcgtggtg tttccgaatt cctcaatgca 2985661 ctgttgaacg actgtcacgc cttggctgaa agctgcgccg cctccaaatg ccgctgccac 2985721 actgacggct tcgagaatgt tttcttctga cgctccctga tcaagacagc cttttgtatg 2985781 atagatcatg caatattcgt cctgagcatt gatggcaatt ccgagggcga tcagctgttt 2985841 ttctctttca gtcagagaat tcccggcaaa gcactgttca gtaaattcgt taaattttct 2985901 tcccatcagc ggcatctttt gttcaaatgt gcctaaacca tgtttatatt gttttaacgc 2985961 gtcctgcatg cttcctctgt cttgattcaa agaaaatccc tccatctgtt taacattcct 2986021 ttttattatg aacagctttt aggaaaatac gcgaaaaaaa ccccggaatt ctcatccggg 2986081 gtttcagtct tattcagata caggaagcac agctccgtcg tattttttct cgatgaagtc 2986141 tttgatcttt ttagagtgaa gaacttccat cagcgctttg atttttgcag aatcttcttc 2986201 gccttttctt actgcgatga tgttagcgta tgggttgttt ttcgttgatt ctacttcaat 2986261 tgcgtctttt ttaggattta atttattttg gatcgcatag tttacattga tgaagaccgc 2986321 gtctccttct ttgttttcat atgcttttgc cgttaattca ggcgctactt ttttgaattc 2986381 aaggtttttc gggtttttct taatgtcttt caatgttgcg tcaactgttt ccactttaga 2986441 atcaagagtg attaatccag cgttttcaag cattgcaagc atacggcctt gttcagcaac 2986501 gttgtttgtc agaatgattg tcgcaccgtc tggaaggtct ttcagtgatt tgtatgtttt 2986561 agagtaaata ccgaatggct ctaagtgaac agcgccggca ttcacaagtt tgtaatctgt 2986621 gttttctttc atttcttgct caaggtaagg aatgtgctgg aagtagttcg cgtccacttc 2986681 tttatcagct aaagctttat tgtacatttt gtaatcacta agcactttca ctttcagcgt 2986741 atagcctttt tctttcagca atggttcagc ttcttttaaa atttccgcat gcggtgtttt 2986801 tgttgccgca acgacaattt ctttcttgcc ggattcagcg ccgttattcg aaccgcaggc 2986861 agccataact cctgcaaata caagcagtaa tgcacccaaa aatagctttt tcaatgtaaa 2986921 tcctccctta tcgtttgtct ataatatttg ttattagatc accgatgatt tgaataataa 2986981 acacgatgat taaaataaac acagtagcaa cgaaggtaac atcagcgtta ttagactgat 2987041 atccttctac gtacgcaagg tttccaaggc ctcctgaacc aatggctccg gcaattgccg 2987101 ttgaaccgat taaagcgatg gctgtaaccg taatgccaga aataagagca ggcattgatt 2987161 ccggaatcag cactttgaaa ataatcgtag acgttttcgc gcccattgat ttagctgctt 2987221 caatcacacc tttatccacc tcacgcagcg cgatttcaac aaggcgcgcg taaaatggtg 2987281 ccgagccgat taccagcgcc ggcaatgcgg cgtttggccc taagatcgtg ccgactaaaa 2987341 atttcgtaaa acctaatagt aaaataatta aaataaggaa cggaatcgat ctgaatatgt 2987401 taacaacggc tgcaatcact gagttgaccg ctttattctg ccagaggctt cctttgctcg 2987461 tcagaaagag cagcaagccg aggatgaccc cgatgacaaa agcaaacagt aaagaaatca 2987521 gcgtcatata aagtgtttca tatgtcgcgt tccataattc agttaaatca acgttcggga 2987581 agtatttttc aaacattcgt gatcacctct gctttcacct gtttgtcatt aatgaatcgg 2987641 atcacgtttt gcacttcttc ctcgtccccg tcaatgtgga tgaacagtga accgtaagcc 2987701 ccatccttcg tctgcgaaat tttcccttgc agaatattga cgctgacatt gaagtttctg 2987761 atcatctctg taatcagagg ctgttcagct gactcaccga caaatgtgag ctgaaccatt 2987821 tttcctgatg ctgtatcatc aagaaggtgc tgaagcgtct ctttcgtttc ttccggctct 2987881 gtcacctgtt gaacaaatcg ttttgtcatt tgttcctttg gatttttgaa gacatcgaga 2987941 acctcgcctt cttcgaccac cttgccgttt tccatgacgg cgactctgtt gcagattttg 2988001 cgtatgacat gcatttcgtg cgtaatcagc acaatcgtca aaccgagtct ttcattaata 2988061 tcggacaata gatccagaat tgaatctgtc gtttgcggat ctaatgctga tgtcgcttcg 2988121 tcacaaagaa gaaccttcgg attgtttgca agcgctctgg caattccgac acgctgcttc 2988181 tgaccgccgc tcagctggga cggataagat ttttcttttc cttctaaacc taccagttta 2988241 atcagttcat tggcgcgctt gatccgctcg ctctttttca ccccggcaat ttctaaagga 2988301 aacatgatat tatctctgac agtccgcgac caaagcaaat tgaaatgctg gaaaatcata 2988361 ctgatctcat ggcgtgcttt tcttaaaccg cgtccattta cttcattaat cttggttccc 2988421 gccacttcca cggttcctga ggttggtttc tcaaggccgt tcagcagacg gattaaggaa 2988481 ctcttaccag ctccgctata tcctataatt ccaaaaatct cacctttttt aatggaaagc 2988541 gagacgtttt ggacagcatt gacatctcca tgtttcgact tgtaaacttt tgaaacatcc 2988601 tgaagattga tcaaagcaat cacctgcctt aacactattc taagaaatct tccggttttt 2988661 tctgcaaaag aaaagccttt ctgcacactt gagcagaaag gcttatataa aatgcctttc 2988721 tctcatcttt caaagctgaa cgcttcgtgt gaattggcac catttcaaca gtgttgatgg 2988781 ttgccgggct tcatagggca cttccctcca cctctcttga taagagaaat atatagtctt 2988841 tttcgtccgg aaattcttaa tgtagaatag cacggcgaat gattaaatgt caataaaata 2988901 aatgatgtca acttttacta ttataataat ttattatttt ttaatttttt aaaatcctct 2988961 gaaaaaatcc atttgtcagc cagagaatgg cttccagctt taacagggcc ctgaatgacc 2989021 cctttacttt gaggcttccg ctctgaataa ggtgctgaag ggaaatgtct ccgtgcaata 2989081 aatcaataat ttccgtttgg tttccgtaaa aggtcaggtt ggacgtttgg ggcggagaaa 2989141 cttttttcat ttctccctgt tcgtttattg agacggttaa ggcttctgct tctccttgga 2989201 aggtaatgag caatgttgag gcattcaaaa ggggttttaa aaacagatgc tgatactcat 2989261 cttctaaaac ttccgctttc tccatatgta caacctccta tttgttggtc atacatacac 2989321 atttctctct ttgtcgcaag aaccccttta taaaacgaac gacaatttca ttggatatgc 2989381 tgagaaatat gtcataaatg ggatgcggaa gatgattttt gtttgatcag ctcatataaa 2989441 taagaaacgg aatgaaatgc atatcctctt tcgaccatct ttccgccttt aaacagcaga 2989501 aaacaaggga cgctttcaat ttgatacgct tttgcgaatg tcggagagta attgacattg 2989561 ttttgataga aggcgacatc cggcagcatt tctttcacca ctgtcagcat tttgcttgca 2989621 agctggcagg tgccgcaaaa cggagtatat aaatatagaa ggtacacatc atcttcaatg 2989681 tgatcaagtt cgtgttcttg gagttctttc atgctataca cctcgggact ttctttcaag 2989741 aaaaatagta tggacattca gattcgcacg cagcaataca gaagcgatat ggtgcctggg 2989801 cgcagccgct acttccttat aggctctgtc gacatggaga tggcaggctt cattaaattc 2989861 acgcttcagc tgttttctca atttctcacc tgattcatca gcatcaacta atatatagac 2989921 gtctttatca taaagctcgt cagccaattc ctcgagcctc agctggctga ttgttccgtt 2989981 tgtgcagata atgcgcatcg gttcattcag gacgctttcg attttctctt tatctgattt 2990041 cccctcgaca atcataacct tttccagctc atccatcttc atcttgttca cctgccgcgt 2990101 caaatttgaa atgttcagat tgtaaaagaa ggcagtgaaa ttcaccgcca acattaacac 2990161 cagccgtttt cgtagtcaca atctacatat tttgcgtcgt ctccagagac cacatcggct 2990221 gtcttataaa atttctcatt ttcaaaggaa taaccggact taagctcata ttcattcatg 2990281 cttgtcattt ggccgatcat ctcattatca tgatataacg agagccggcc attttgaaag 2990341 cggcctgtca cgtcattggt gacatcgagc ttttgtttgt cgaaagccat attggacacc 2990401 tcccataacg ttagcgtgtc caattgcttt tacggctatc ctgttttagt cttcttgtgt 2990461 catctcttcg tattgctctg ctgtcatcag tttttcaatt tcagaagcgt cagatggctc 2990521 aacgacgatc atccatgctt tttcgtacgg agattcgttg acgaattccg gactgtcatc 2990581 aagatcttcg tttacttcca caaccgttcc gttaatcggt gcataaagct cagataccgt 2990641 tttaacggat tcaacactgc cgaatggctc gtccgctttg atttcagcgc ccacttcagg 2990701 aagttcgaca aacacgatgt cgcctagttc ggactgggca aaatgcgtaa ttccgattct 2990761 ggctttttct ccttcaactt ttacccactc gtgttctcct gagtaacgca aatcttttgg 2990821 tatgctcaat tgaatccctc cattttttac agcactacaa taagaagata ccacactttt 2990881 caaaaaaaat ttacattaag cccagttttc ttcaaattgg tcttctttaa atccgacagt 2990941 cactttttcg ccgtctgttg taagcgggcg tttaattagc ataccatctg aagccagcag 2991001 ttcgagctgt tcgtcctctg acatatgata cagcttttcc ttgagattga gctcgcggta 2991061 tttcatgccg ctcgtgttga aaaatttctt gagatccagc ccgctttttt cataaagcgc 2991121 ttttaattct tctttgcttg gcggctgctc agcaatatgt atttcgttta tttctttccc 2991181 atgctcttca agccacttct ttgctttgcg gcacgttccg catttagggt accagtaaaa 2991241 agttaacgac atcttcttcc ccctcaataa aataatcgag gttattttaa cacagtttgt 2991301 tttaaaaacc taaaacagtg cttcttaaaa aagagctccg cgcatgcgga gctcatggcc 2991361 aatcagacag tatatttctc agcctcaaaa atgcctgccg ccgcctcgcg ttttttctga 2991421 atcacgtttt taggcgttac gcgtgtcagc ttgcgcagag cggaaagcat catgcggagt 2991481 gaatctcctt cttccattgc gataagggat tcctttgcat gcgcttcgat ttcgttaaag 2991541 gcctcttgaa cgaaaatttc tgtgtacagc accttttgcg ctgctttttc agcgccttgt 2991601 gcggcaatgg ccttttccgt tctgagcacg gctgattcca ttgcgtatac attgctgacg 2991661 atatccgcta cgttcacgag aatttcttgc tcacgatcga tcgcttttcc gtatttttgc 2991721 gcggctaggc cggcagcaaa caacgcaatt tttttggctt gcttgacgat atatttctcc 2991781 tgctctaaga cgccgcttcc aggctcttca ggcataagca tcatgagttc ttcctgcagc 2991841 gactgcgctt tttcgaataa aggcagctcg cctttaagcg cttttttcag gaaggtgctt 2991901 ggcacgatta accggttgat ttcgtttgtg ccttcaaaaa tccgattgat ccttgaatcc 2991961 ctataggccc tttctacttc gtattcctgc ataaagccgt agcctccatg aatctgcacg 2992021 ccttcatcaa cgatataatc aagcgtttca gagccgaata ccttattcag agagcattcg 2992081 atggcgtatt ccgcaatcga tttggcgatt tgccggccgt ccttgagatc ttcggccgtg 2992141 aactggctca tattgtcttc aaacagcccg acggttctgt atacagagct ttccatcgca 2992201 tacagccttg aggccattgt cccgattttt tcctgtgtca atgaaaaacc agcaatcggc 2992261 gttttaaatt ggcggcgctg atttgcgtat gccgcagaca gctcgatgac gcgtttagat 2992321 gcgccgattg tgccaaccgc cagtttgtaa cggccgatgt ttaaaatatt aaaggcgatg 2992381 acatgccctt tgccgatttc tccgagcagg ttttcctttg gcacttcagc ttgatccaga 2992441 atgagggttc ttgtcgatga tcccttgatt cccattttct tttcttccgg tcccgtggag 2992501 acacccggga actctttttc tacaataaag gctgaaaact tgtcgccgtc taccttagcg 2992561 taaactacaa atacatcggc aaaagcagag ttggtaatcc actgtttttc ccctgttaat 2992621 acataatggg ttcctgcttc attcagcaca gctgttgttt ttgctccaag tgcatcagac 2992681 ccagagccag gctcagtcag agcataagcg gcgatctttt cgcctgaagc gagtccaggc 2992741 aaatattttt tcttttgttc ttctgacccg aaaaagacga tcggcaagga accgataccg 2992801 acatgcgcgc cataagaaag agaaaagctt cccgcacgcg aaaatttctc agtgatgagt 2992861 gccgagctga ttttatcaag gccgagcccg ccgtattctt ccggcacatc ggcgccaagc 2992921 agccctagtt cgcccgcttt cttcaacagt ctgacagaat gctcgaattg atggttttcg 2992981 atatcatcta tatgagggag aacatcttgc tcgatgtaat cctctgttgt tttcgcaatc 2993041 attttatgct cgtcagtgaa atcctccggt gtatacattt gatcgtatgt gacatcctcg 2993101 attaaaaatc cgccgccttt ttgtacgtca gccgcttttt ttgccatttg tttttccccc 2993161 tttagcataa ttcaaataca ccggccgctc ccattccgcc gccgatacac atggtcacga 2993221 ctccaaattg ctcgtttctc cgtttcattt catggatgag tgagagtgta agctttgtgc 2993281 ccgtacagcc aagcgggtgt ccaagcgcga ttgcgccccc gttgacattc actttttctt 2993341 catcaattcc caattccctg attacttgaa tggcctgtga ggcaaaagct tcattcagtt 2993401 caaacaagcc gatgtcctgc agctgaagtc cggcaagctt caaagcgcgc ggaatcgctt 2993461 ccaccggtcc gattcccatc acttccggcg gcacgccgcc taccgcaaag gagcggaatt 2993521 tcacaagcgg cgccaggcca agagcatcgg ctttttcccg gtccatcagc atgacagccg 2993581 ccgctccgtc actcgtttgt gaggaattgc ccgcagtcac cgtcccgtca acggaaaagg 2993641 ccgggcgcaa tgtcgataag atgtctgcag tcgtttgcgg gcgaacacct tcatcctgag 2993701 aaaacacaaa ctgtttttcc ataggcttat ggtcttctcc gatttctgtc accgtcactt 2993761 cgacgggtac aatttcatct ttaaattttc cttctgcaag ggctttagcg gcgttttgat 2993821 ggctgcgaac ggcaaacgcg tcttgatcct cacgggagac gccgtatttt ttcgcgactt 2993881 gctcggctgt gtgccccatg ctcatataat attccggtgc cttttctgcc aaagcaaggt 2993941 tcggacgggt aacatgcccc atcatcggaa cttgcgacat ggattctgct ccgccggcga 2994001 tcgctgtatc gtaggcgccc agcataattt tttctgctgc atacgcaata gactgaaggc 2994061 ctgaagagca atagcggtta actgtaatcg ccggaaccgt gtacggcagg cccgcgagcg 2994121 caccgatatt tctcgccata ttaagcccct gctccgcttc aggtgttgca cagccgataa 2994181 tcaagtcatc aatattgcct tcgtagccgc ctgcccgttt cagcgtttct tttacacaaa 2994241 tcgctcccaa atcatccggg cgaacggtgg ccaacgatcc tttttttgct tttccaaccg 2994301 gtgttcttgc acctgacaca atgactgcct ctttcataag ctccctccta attccgtaaa 2994361 ggtttacctt tcacaagcat atgctgcatt ctcgcttgag attttgcctc tcctgacaaa 2994421 ctcaaaaacg cttctctttc gatctccaat aaatactctt catcaacctc tgtaccaaac 2994481 ggcacttttc cgcccgcaat gacataagcg agttttttcg cgatcttaaa atcatgctca 2994541 gatatatagc cggacagctt catctgctca gcgccaagca agagtgccgc ataaccggtt 2994601 tctcccggca ccttgacctt ttcttttaca ggcggccgcc agccggtatc gtataaagat 2994661 gcggccagct gcttcgcatc gtataacagg tggtcttgat tcacgctgat ctgatccgtt 2994721 tcttttaaga tgttcatctc acgagcctct tgagcggaag cggacacttt cgccatcgcg 2994781 attgtttcaa atgttttcat tgccgcattc atcggatcat ggccgcggcg aagatggttg 2994841 atgtacagct ctttgttacc tcctccgcca gggatgaggc cgacaccgga ttccacaagt 2994901 cccatatagg cttcgcttgc cgcttgaatg cgcgccgccg gcaggcatgc ttccgttcct 2994961 ccgccgagcg tcatgccaaa tggcgcggcg acgaccggtt tcgcactgta tttgatcttc 2995021 atcatcgtct cctgaaaacg gcggatcaca aaatcaactt ccaaaaagtt gtcatcttgg 2995081 acttccatta agatcatggc gagattcgcg ccgacgcaga aatttttccc ttgattgccg 2995141 atgacaagcc ccttgtaatt ccgttctgtt tcctctaatc ctttgtggat catttgaatg 2995201 atatcgaggc cgatcgcatt gcttttcgaa tgaaattcaa gaagggccac atcatctcca 2995261 aggtcaatta agcttgctcc gctgtttttc gcaatcacgc cttttgtttc tttaagtgct 2995321 tgtaaatgaa ttcgtttttt gttttctttc acggctctgt attcgccgcg gtcataataa 2995381 aataccgttc cgttctcttt gatgtagaag gtttcatttc ctttgtccag catctctttt 2995441 atccagccag gcatatctgc tccaagctgc tcaagctttt ccgctgactg cttgaggccg 2995501 atggcgtccc acatctcaaa aggtcccagt tcccagccga atccccactt catggcttgg 2995561 tcaatcgcat gaatatcatc ggcaatctcg ccaagcagct cggctgagta aagcagggtt 2995621 tgagaagtga tattccacag caaacggccg gccctgtcat ccgaataaat aagcgctttc 2995681 attttggctt ttgtcccttt tgcctgtttt gccgcttcaa gtgccggtga tttcattttt 2995741 gtccgctcgc cgtaagtaag cgtcactggg tcaagctcat aaatcgtttt tccttctttt 2995801 ttataaaagc cttggccggc cttgcttccg atccaccctt tttccagcat atcgttcatg 2995861 aagcttggaa tgcgaaacac ttctttttca tcgccatcag ctttgtcata cacatttcgg 2995921 gcaacgtggg cgaatgtatc gaggccgacc acatcaagcg ttctaaaggt ggcgcttttc 2995981 ggcctgccga tcagcggtcc tgtgatcgaa tcaacctccc cgacctgata accgcctttc 2996041 agcatttctt ggactgtcac gagaagcccg taagtcccga tgcggtttgc gataaagttc 2996101 ggtgtgtcct ttgctgtaac aacgcctttc ccgaggacat tttctccgaa agctgtcata 2996161 aactttaaaa tatcaggatc cgtttcctta atcggaatga tctctagcag ctttaaatat 2996221 cgtgcgggat taaaaaaatg cgttccaaga aaatgggctt taaaatcatc cgaccggcct 2996281 tcagccattt cctgcactga tatgccggat gtgttgcttg agacgatgct tccagtcttt 2996341 cgatgttcat ccacaagagc gaaaattttc tttttgactt caaggttttc gacaacgacc 2996401 tcaataatcc aatctgcttc tttcagtttt tctgcatcat cctccagatt gccaggtgta 2996461 atataggagg tatttttcgc tgatgtgagg ggagcgggct tttgtttcag cagttttttc 2996521 atcgcctgcc ggctcagcct gctgcgcacc tccgaactgt ccttcgtcag cccctttttt 2996581 tcctcttcct ttgtcaaatc gttcggcaca atatctagca gcaggacagg aattccgatg 2996641 ttagccaaat gcgccgctat cccggaaccc attacccccg atcctaaaac ggctgccttc 2996701 cgaatgtgtt tgtgcatgag atatccccct tgaacattga atgaatagtc attcattttt 2996761 tgactaaaaa aaatgaaacc cgtttcttct ttcatcttaa aagatttccg gttcgacttc 2996821 aatagctaat ttgttatttt tttgtatgaa gcctataaaa gtcgggcaac ttaagcccgg 2996881 aggtgaaggg aatggtacga gagaaaaaaa atccgtcttc agcggcagtc agcgcggcga 2996941 gcgtaaaggg agatgccggt ccgactcagc attacggcgg cggaaaacgg acaagtcaaa 2997001 atcagcagta taaaaaacat aacatgggac aatcataatg cagctgcttc ccacggctgc 2997061 tttcactttt tcaaaattcc ttttaacaca aacgctgcat tggcaggccg ttcggcaatt 2997121 cttctcataa agtagctgaa ccagtccgtt ccatatggga catacacacg cattctgtag 2997181 ccttccttgg cgagttcctt ctgacgctcc ggcctgatgc cgtatagcat ttgaaactca 2997241 aattgcgatg cggggatttg atgttcggcg acgagctgtt tcgtaaatgc aatgatgtca 2997301 tcgtcatgtg tggcgacagc cgtgtagttc ccgcttaaca actgcagctt tattaagctc 2997361 tgaaaatgaa ggtccgtgcc tcttttgtcg ggaaacgcta cagccgcaga ttctttataa 2997421 gcgcctttta caagtctgag attcggcttt aagtcccgca tctttctgat atcttctgcc 2997481 gcccggtaca aatacgcctg aatgaccgtg ccgagcttct caaattcctg tttgcattgc 2997541 ctgtaaatag aaagtgtctg ttcataatga gaatagtctt ccatatcaat ggtcacagca 2997601 acatcatatt gcttcgcaac ggaaagaatg gcgcgcaaat gagtaagagc aagttcttct 2997661 gaaagatcga gcccgattga ggtcagctta agtgaaagct ctgaattcaa ttgatgttcg 2997721 gcaatggctt gaatggcttt cttgcattcc tctgcgactt ggtttgcttc tttttccgaa 2997781 gctgcatact cgcctaaata atcaattgtt gcacacaaac cggatctgtt tagccttttg 2997841 acggtcttaa ccgccgattc aatcgtatcc cctgcgacaa accttcgtgc tccaagccgc 2997901 gttccgtatg cttttgcgaa cttggtaagt gttttatttt gagataagaa taaaaacaca 2997961 tgtctcaaca tccgactccc tcccgccgtc atcttcaaaa cacctgtata taactcccag 2998021 tctgaaggaa actataaaat gaacagaaac caaaggagga tcacaatgga taatcagcag 2998081 caatctcaaa tgccgccttc cgttatttcg acaaaggatc atttgtatct caatgacatg 2998141 ctgaactgga atttgctcgc gatgaaaaaa gcgcatttca tggcgcagca gtgccaggat 2998201 caaacgttaa agcaagaact cgaccgcgtc ggacacatgc atcatgatca ctatcaaaga 2998261 atattaaagc acctgcagcc aggccagcag cagtccggct acatccaata aggaggcgcc 2998321 agaatgaatc agcaaaatca aaaaatcagc aacccgcaga cacctgtacc gacaacatcg 2998381 gaaatgaatg acagagattt cgtcaacgaa ttgctgacaa ccgaaaaata catgacaaca 2998441 gcttattgca ctgccttgca cgaattcagc cacgagtctc tttatcagga tattcaatcc 2998501 atttttgatg agtcacaaaa agcgcaaaga aaactatatg atctcatgtt ccaatatgga 2998561 tggtattctg ttgaagcgga ggattcacaa aagctgcagc agtcctatca aaaattccag 2998621 cagaccattc agcagcagtc tccttatcag caataacaac attagtaaaa aggatacgat 2998681 gttctttcgg gcatctatcc tttttttgtg taaaatcagt tgacttttca tttacgctta 2998741 tttatattta ataagcatta actattttgt cattaaaata tatatacagt gtatgtaaca 2998801 gaggggaaat gaatatgaag agtgcggatc agttaatgtc cgatattcaa ttatcgcttc 2998861 aggcgctctt tcaaaagata cagcctgaaa tgctggaaag catggagaaa caaggtgtca 2998921 ccccagcgca gctgtttgtg ctggccagcc taaagaaaca cggcagcctc aaagtttctg 2998981 aaattgccga gcgtatggag gtgaagccaa gcgcggtgac gctgatggca gatcgccttg 2999041 aacaaaaaaa tcttatcgcc agaacacaca acacaaaaga caggcgagtg attgatctca 2999101 gtcttactga cgaaggagac ataaagttcg aggaggtttt ggcgggcaga aaagccataa 2999161 tggcgcgcta tctttccttt ttgacggagg aggaaatgct gcaggcggcg catattacag 2999221 caaaactcgc acaagcagca gaaacggatg aaaagcaaaa catgaaaaga ggaaacggat 2999281 gaaaatgagt aaagaaggca aacaatcaaa acgaacgtta ttaataacag gcttaattat 2999341 tgccatgttt ttttcagccc ttgacggtac cattgtcgga acggccatgc cgaaaattgt 2999401 cggtgatctg ggcggtttga gcatgatgac ctggctgaca actgcatatt tgttaacatc 2999461 aacaaccatt gttccaattg ccggtaaact ggctgattta ttgggacgcc gcattgtcta 2999521 tgtatcaggt ttgattattt ttatggccgc ttctgctttg tgcggaatgg ccaacaacat 2999581 gacggaattg attatcttcc gtggactgca gggcatcggc ggaggcatca tgatgccgat 2999641 ggcgatgatt gtcatcggtg acttgttcac aggaaaacag cgtgctaaat tccaaggtgt 2999701 ctttggcgca atttacgggc tggcttcagt gattgggccg caaatcggcg gctggattgt 2999761 agactcgtta aactggaaat gggttttcta tattaacctg ccagtcggaa ttattgcggt 2999821 tatttttatt gccaggggat tacagggacg ccagcagact ggtccgatca acttcgatat 2999881 cgctggtatt ttcacaatga ttgtcggtgt ggtcagcctc ctgctcgcct taagctttgg 2999941 cggaaaagat tatgcatggg attcatggca gattcttggg ttgttcgctc tcgcactgat 3000001 cggcattgtc agctttatca tcgtagaatc aaaagcaaaa gagccaatcc tgccaatgta 3000061 tttatttaaa aacagaacat ttacatttct aaacttgatc ggcttcttta tgagtatcgg 3000121 tatgtttggc gccattacgt ttgttccttt ctttatgcag ggaattgtcg gtgtaagtgc 3000181 gtctgaatcg ggtacaatta tgacaccgat gatgatttct atgattatca caagtatcat 3000241 cggcggacag cttgtttata aaattgggat taaaccgcaa atcattacag gcatgctggt 3000301 tatggccggc ggattcctgc tgttaacgac attggatctc gacacgagca agcttgtcgc 3000361 tacatctttt atggcgatta ttggtctggg aatgggtctt gttatgccga ttctgacatt 3000421 ggctttacag gaaagctttt cgaaggagga gcttggagtt gtcacttcat ccagccaatt 3000481 cttccgttct atcggcggaa cattcggcat taccatgctg ggagccgtaa tgaatgcgag 3000541 atcaggaaat ctattaacag ataaattggt tccatattta gactctcttc cggcacaggc 3000601 aagctcgttt gccgcccagc taaagggtat gattgataca aatccgcaag ggctgctgca 3000661 atcactgttc agtccggacg cggtcaaaca aatccctgcg gctttctcat cccatattgt 3000721 gccgatttta aaaacatcgt tgatggattc gctccacagc gtgttttata cgggcctgat 3000781 ctttatcgca gtcggagccg tattcacctt gttcttaaaa cctatcaagc tatcaaataa 3000841 gaaagcggaa gaccaacaag aaaaagagaa ggcggcaaaa gccgttgaat caccttccca 3000901 ttaatagagc accccgcggg tatcaatccg cggggttttt tattcaatca tctgggctct 3000961 tccatttccg aaagaccaat cctcatcctg atttccggcc agcatgataa acacatcttc 3001021 ttttcttaca ccaagctcgg aatgaatccg gctcgcgatt gagcggtaaa gtgctttttt 3001081 ctgttcagtt gttcttgact gtttcagtgt aaaatgaatg tatatcagtt catcagtacg 3001141 ctcgacttgg agataaaatg gatcataaaa aaattcgctt ttttcatatt gtctgatgac 3001201 ttggaaatag tcatcttccg gcacattgat ttcttcaatc atcgattggt ggatagtcct 3001261 gctcagtttt tgaagccaca cttcgcttct tcccgaccgt aaatgaatct gtacaaatgg 3001321 catctccccg catccctttc tttacagcgt ctgtccgctg tcaattgtga taatttggcc 3001381 tgtgagtgat tcctgttcaa ttagtgaaca aatcaatttg gcaacatcat ctggttcagc 3001441 aatacactgc agcagcaaag agccgatcat gcttttcatt ttttcttccc gtccggccca 3001501 ccatctcgtt gccacagctc ctggtgctac accgctcact ctgatttcag gcgctaaggc 3001561 gtgggccaat gatttcgtta aaccgtgcac cgctgatttt gatactgcgt aaggcattga 3001621 tgagccggca ccagttatcc ctgcgatgct gccgacgttt acgatcgccc cgtccttgct 3001681 tttcttcatg aacggaacca ctgcccgcgc gcagaaaaac atccctttca cattgacggc 3001741 atacagctca tcctagacgt cttctgtcgc agcctcaaga tcatccattg gaatatgccg 3001801 tgtaatgctg gcattgttga ctaaaatatc aaccgtgccg tgtgtgttca cgattgcttg 3001861 aatcatatcc tgcacgtcgc tgtttttgga tacatctgct tggatggcga aggcttgccc 3001921 gccagctttt tgaatcattt ccactgtttc ctccgcttct gattgcgagc gtgaataatt 3001981 caccgccaca atcgccccac gctttgccaa ttccatactg gctgcttttc cgattcctgt 3002041 gccgcccccc gttacgagag ctattttgtt caagacattc attgccgcca ctccttgctg 3002101 ttgactaaag tatatttctg attccattgt aatccagctt tgatgttacg tataatgatt 3002161 gttaaagata ctagatatca ctcagattga tagtaaacga acggaggagt tcaaaatgga 3002221 aagcggagat ttacgtgtgt ttcaaatggt agctcgtgaa gggaccatta cgaaagcagc 3002281 cctgcagctt ggctatgtac aatcgaatgt cacggccaga attcaacaat tggaagctga 3002341 gctgggtacc acactgtttt tgcgccataa tcggggcatg acactttctg caagcggaaa 3002401 attgctgctg gactacgcaa ataaaattat aggccttctt gatgaagcgt ctaaagcgct 3002461 ctcatcctcc gcagaaccaa gcgggccgct tatgatcggc tgcactcaga caaccgccgc 3002521 ggtaaggctt ccaaagcttc tggcatctta ttatgaagaa catccaaacg tccagctgtc 3002581 tttaacaaca ggacatacgc aatttctcct tgataaagtt cttcgttatg aattggatgg 3002641 cgcgtttatc ggatgcgaat gccatcatcc tgagctcgaa tcctatcctg cgtttgagga 3002701 agaaccagta gttgtttcgg ctgcctccgt gcccgatgtt gaggaagcca tcacaaagcc 3002761 gattctcgtt tacagcacag gctgttcgta tcgagaaaca cttgaaaaat ggctgcgttc 3002821 cgtcggtgtc acacagccgg tcattatgga atttgggacg cttgaagcaa ttatcggcgg 3002881 ggttacagca ggtcttggca tctcgttgct gccaagaacg gttgtgcaga aacatgaagc 3002941 agaaggatca attcgattgt acccgctgcc tgaagctctc agccagatga aaacagagtt 3003001 tattgttcga aaagattcgt ttatcagcag cgcgctgaga acctttatgg attcctttac 3003061 gccagttaaa acggctgaat cacaaaaaag cagtctgcta taatgaacag actgcttttt 3003121 ggctattgtt tgtttcgatg cgcttcattt aattccttaa tatgctgaat gatctcttta 3003181 atgccctgct tcgcgtcggg gtatgtcgca ttccaatgct tagcgagcgg aggcatgctt 3003241 ttggctatat gggtgtacaa aatccattgc ttcacttctt cttttagctc atcgtttgtt 3003301 tcaccaagca gaagctcagt atacttctcc agcaatccat caagctgctc ctgaagtttt 3003361 tgttccattt tccatcttcc tttcgaaaaa acagcaagga gctttctcaa ttgaaagctc 3003421 cttcgctgcg ttatttatcc atgtgatgtg aaagccgctt cctggacaat gcatctgccc 3003481 ctgccatgag gaatgcaaag aggcgttccg aagagcgggt cctgtgtaac ctgacagttc 3003541 atagaaaaca cattttgcac aagatcacaa gtgatgacct cttccggacg gccttctgca 3003601 taaatccgtt tatcttttat ggccacaaga tgatgcgcat agcggcacgc caagtttaag 3003661 tcatggagaa ccataacaat cgtccggtct tccttttcat tcagctcaaa cagcaaatca 3003721 agaatttcaa tttgatgcgt catgtctaaa tacgtcgtcg gctcgtcaag aaggatgata 3003781 tccgtttcct gggcaagcgt catcgcgatc caagcccgct ggcgctgtcc gcctgacaaa 3003841 gaatcaacgg cacggtcagc catgtcctca agctttgttg ctttaagcgc tctttcaact 3003901 gcttcctcat cctcttttga ccactgcttc agccagtttt ggtaaggata tcttccttgc 3003961 ttcaccagct gatgcaccgt cagcccctct ggagccgaag gaccttgggg caggattgcg 3004021 agctcttttg cgacttcctt cgtcggaagc ttggcaatcg ctcttccttc cagcagcact 3004081 gaaccgcctc tcggcttcat caggcgcgct aatgaacgta aaagtgtcga ttttccgcag 3004141 ccattgctgc caataaatac ggtaatttca cctttgggaa ttgttaaatt caactcatca 3004201 ataataacgg catccccgta tcctaagctc agcgtttctg tagaaattgc actcataccc 3004261 ataaccgctc ctttttgctg gctttttagc agcactatgt attgcacgtt ttctatatac 3004321 atgcttttaa gtcaattgtc atcaatgcaa atgattccga tattcagcca tttgatatgg 3004381 tcatatatcc ctcattgtag cagaaaacac tgactttgaa aatcattttc aattagtttt 3004441 atggacataa ttgacgttta tgggtttttt atcacaagat tacttcttga tttctctgat 3004501 ggagccgtcc ttcagcttca attttaaatc gatatgatca taatgactgt ccagattaaa 3004561 tgctgccagc acactgtgta tcacttctgt ttcagccatt tggtctgtca cggaaagctc 3004621 gctcaaaatc attttcatct catctaacgc ttcttctcct tcctgattga caccggagag 3004681 cttatcctgt atttccgctt tttcctgagt cccgttcttt gtatagattc cttcataacg 3004741 gttatgctca ccatccccgt agctcacacg aagcgaaaaa ttactgtagg gaacggactt 3004801 cagctgggtg acggctgtat tttctccttc tgcctgatgc tggtcttcat tgaaacggca 3004861 gcccgcaatc agaaccactg cgagacatac agccccggct gctctgatca aatgcatatg 3004921 tttcccccct gtaggattcc atttatttta ggtatatcca gagaatgaaa tcctcattca 3004981 gagaagaatt gaaaaagccg gggcatttaa cgccacggct ttttctttaa gattcggtca 3005041 tttgtaaaaa ggtttcggcg tcacgcacag ccagcttgat ggcattctcc cagaaatcgc 3005101 gctttgtgat gtcagcgccc aaatgcttca tcgccaaatc ctccactgtc atagaagccg 3005161 tatcgcgcaa tagcgccata tacttctctt cgaatgtgtc tttttcttca agcgccaacg 3005221 cgtaaatacc aagagaaaac aggtagccga atgtataagg gaaattgtaa aacggcaccc 3005281 tcgtgatgtg aaaatgaagc tttgatgccc aaaaaagcgg atgatattct tctaacgcat 3005341 tgcagtatgc ctctctttgc gcctcttcca tcagctcatt caagcggctg gccggtacca 3005401 ctccccgctt tcgttcctcg tagaatctcg tttcaaatag aaatcttgcg tgaatgttca 3005461 tgaagaacgc aacgcttctt tgcactttat cctccagaag aacaagcttt tcttccctcg 3005521 tctcggcctg ctggacagtc gcgtccgcca ctatcatctc tgcaaacgtt gaagctgttt 3005581 ctgcaacgtt catggcgtag gaacggttta acggcctgac gttgagcatt gcttcctgat 3005641 ggaacgcgtg cccgagttca tgcgcaaggg tagagacatt tgaggcgctt cccgaaaatg 3005701 tcatgaaaat ccgggattcc ccgctgtccg gaaaactggt gcaaaagccg ccgactcttt 3005761 ttccgctcct gtcttccgcc tcaatccagc cgtcccgaaa cgctttttca gtgaatgagg 3005821 acagcttttt gccaaacgtt gaaaactggc tggtaatgat atttgcggct tcatcatacg 3005881 aatagacctt tccgtcagaa ccgatcggtg cctcgacatc gtaccagctg agtttttcaa 3005941 ggccgagcat ggatgctttc cggttcaaaa actgaacgaa cggcttcttg ttttcagtga 3006001 tgacctgcca catcgtatca agtgtttctt ttttcatcct gttaatttgc agcggttcct 3006061 tcaggacatt ctcccagccg cgcgctttat aggtttcaag ccggaatccc gccaaatgat 3006121 tcagcgtgct gctgaaaata tcttgcttgc tctcccaagc ttggcggaaa cgttcatata 3006181 ctgtttttct gacagtacgg tcttgatgat ccatcatatt ctccgcctga ccgacagaca 3006241 attgcttgtt ttcaccgttt tcctcatacg ggatcgtcat tttcccgaca accatattgt 3006301 ataagtcact ccaagcgtga tatccgtcca ccgcaaggtt tccgatcagt ttttccttac 3006361 cggggctaag cttttcggca accctctgtc ttctttcatt taatatgtaa gaaacatcgc 3006421 gcaatcccgg ttttgttaac aattcattcc acacgtcttg attaatgtcc acaagtttat 3006481 gatctaatgt aacgagcgac gattgaaaat ctgcggaaag ccgattcatg aggcctgatg 3006541 ctctatagcc ttttgatcat tgatattctg ggcctggagg caagcaacaa aagcgccggc 3006601 ctgctgaagc ttgacggatg tctgttcgaa taaatcaagc aacgcggtca gcccttcagc 3006661 ctcttcaggc gattcaggca cctgaaacgc atcagtcctg tcttgaaatg cacgcagact 3006721 ttgtgacagc ttctcaatat aacctttgaa ttcttccgat tggctcccgc ccttaaaaaa 3006781 tgaatcaaga tcccatcttt ggcctacccc ttgcagcgcc atatcacaaa acccctttcc 3006841 ttctttcgtt ctattataga acaattctga attattgtat aaaaatttct attacaggcg 3006901 tcatttcgtg ttcaggatag tacaatagct gtagcagttt aataggaggg ttaggatgaa 3006961 taaaaaaata gccatcgtga caggagcgtc cagcggcttc ggtctgctgg cagctgtaaa 3007021 gcttgcccga tcatttttcg tgatagccac atcaagacag cctgaaaaag cggaacagct 3007081 tcgagaattg gctgcagcac acaatgtgtc tgattctatt cacattacag ctctcgatgt 3007141 caccgatgaa caatctatag tctcattcgg aaaagctgtt agtgcttacg ccccgatcga 3007201 tttactcgtt aacaacgccg gaacggctta tggaggattt atcgaggatg tgccgatgga 3007261 acatttcaga caacaatttg aaacgaatgt cttcggtgtg atccatgtga caaaaaccgt 3007321 gctgccttac ataagaaagc atggcggcgc aaagattata aacgtgagca gcatcagcgg 3007381 actgacagga ttcccagcgc tgtcgccata tgtttcttcc aagcatgcat tggaaggttt 3007441 ttctgaaagc ctgcgtatcg agctgcttcc gttcggtatc gaaaccgctt tgatcgagcc 3007501 gggctcatac aagacatcga tctggtcaac gtcattatca aattttatgt cggtgcctgc 3007561 tgacgattca gcctatcatc aatactataa aaagatcctt tcctatgttc aaaaaaacgg 3007621 agaagaaagc ggagatcccc aagaggttgc cgacctcatt tatcaattgg caacaaaaca 3007681 gcacataaag aatttgcgat acccgatcgg aaagggcatc aagctcaccc tgctgttccg 3007741 atcgcttttt ccttggtctg cgtgggagtc tatcctgaag aaaaagctat tcagctgatc 3007801 taaattataa ttattataat ttagtattga tttttattta gtatatgata taattaagtc 3007861 aacagatcac aaggaggacg ttatcttatg aaaactgaaa acgcaaaaac aaatcaaaca 3007921 ttagttgaga attcactgaa cacacaatta tcaaactggt ttcttttata ctctaagctc 3007981 caccgtttcc attggtatgt gaaagggcct catttcttta cattgcacga gaaatttgaa 3008041 gaactttatg accatgcggc tgaaacagtg gataccatcg ctgagcgcct gctggcgatt 3008101 ggcggacagc ctgttgccac agtgaaagaa tacactgagc atgcatctat cacagacggc 3008161 ggaaacgaaa catcagcatc agaaatggta caagcattgg taaacgacta caaacaaatc 3008221 agcagcgaat ctaaattcgt gatcggcctg gctgaagaaa atcaagacaa tgcgacagcg 3008281 gacttgtttg tcggattaat tgaagaagtt gaaaaacaag tgtggatgct ttcctcttat 3008341 ttagggtaac aaaaaagctg aaccttaatc gggttcagct ttttgttttt tcttagcttg 3008401 aactgctttc tgtctgcttg gtcagtgttg cgttcaacgt tttcgttttt ccctttcgca 3008461 gcacttggat tgttgtttta tctccgactt ttaagtcttt gtaaaggatc tgacggatat 3008521 ccgcactgct ttccacgtct ttaccgttta gtttgacaat gacatcctca gatttaatac 3008581 ctgctttttc tgccggcgaa tttgcttgaa cttcttttac ataaacacct ttgcccaatt 3008641 gatctccaaa caggccgagc gtattttcct gataggtttc aggaacttgt gacatgtcaa 3008701 tcatctgcac gcctaaaaac ggacggtcca ccttcccgtt ttgcagcagc tggtcaacaa 3008761 tcggctcgac atcattgctt gggatcgcaa atccaagtga ttccacgccg ctttcgctca 3008821 ccttcaagct gttgatgccg atgacctggc cgcttgcatt gattaatggg cctccgctgt 3008881 tccccggatt gatcgctgca tcggtttgca gcacgttcat ttccaccgtc ccctgtgttg 3008941 tatccacatc aattgtccgg ttcagtccgc taatgatacc ttgtgtcact gtaccggaaa 3009001 actgctgtcc gagcgggtta ccgatagcga ttaccttttc gccagtgcgc agctgtgaag 3009061 agtcaccaaa gctcgccact ttttttacat tcttgccgct gatttccaaa actgccaaat 3009121 cagtaatggt atcgctgccg acaagcttgg cagtttccgt ttctccgttg tatagcgtaa 3009181 cagtcagctt gttcgcgcct tcaacgacat ggttgtttgt aatgatatac gctttatcgc 3009241 tgtctttttt gaaaataaca cctgacccgg ttccgctttc actttctgag ctggagcctc 3009301 ctcccgtgcc gaatgtgtta ttttgagagg tttggatatt tgagattccg acaatcgtag 3009361 gctctaaatc ctctaccata tcagcgatgt ttgatgcgtt cgttatcggc gccgttgtaa 3009421 aattatcaga ctgcacctgt ttatttgcgg aagcggtttc ggtcgcctga ttttggtctg 3009481 acggcagata aggcgcgatg ccaagcatga ggcccccgcc gataataccg cctaaaatcg 3009541 ggctcagcca tgcggctctc cgtttctttt cttttttcac agccgtttct tgcttttcca 3009601 tttctaaagc agaagccgtt tcctgccgtc ccgcttcata cgacacaggc gcgtcaagca 3009661 attcttgttc agaatgtcca atcagcttct ggttttctgt attctgctgt tctgtatgtg 3009721 aaggttcagt ttgatgttga tcgttttggc catcacgtcg ataatccatg ttcttacact 3009781 cctttaacgg ttattcattt atcgttacat attcatcgca tgtacaagtt caattgtccc 3009841 aataatgagg agaaaagcaa agcaccaaaa tagaatatgt ttgatcatcc tacatcttcc 3009901 tcgctctttt tctcttcctt tcttccctta accatatcat aaacaaacat tgtgggataa 3009961 aaatgaaaag aatatgtgaa attatgaaaa ttgcctgccg tatgttaaaa ctagtttata 3010021 atgacgttga aaggatgtga agagccttgt catacaccat ttatctagtt gaagatgagg 3010081 ataacctgaa tgaactgctg acgaagtatt tagagaatga gggctggaac attacatctt 3010141 ttacgaaagg tgaagacgcc agaaagaaaa tgacaccgtc tccccaccta tggattctcg 3010201 atatcatgct gccggatacc gacggctata cattaataaa agaaatcaag gcgaaagatc 3010261 ctgacgtgcc ggtcattttt atttccgccc gagatgcgga tattgacaga gtgcttggct 3010321 tagagcttgg cagcaatgac tacatttcaa agccgttttt gccgcgggag ctgattatcc 3010381 gtgtgcaaaa gctgctgcag ctcgtatata aggaagctcc tcctgtccaa aaaaatgaaa 3010441 ttgccgtctc ctcgtatcgg gtcgctgaag acgcccgcga ggtctatgac gaaaacggga 3010501 atatcatcaa tttgacgtca aaggaatttg atctgctgct attatttatc catcataaag 3010561 ggcatccata ctctcgtgag gatatcctcc taaaagtgtg gggacatgac tacttcggaa 3010621 cagaccgggt cgttgatgat ctcgtccgga gactgcgcag aaagatgcct gaattgaagg 3010681 tggagacgat ttacggtttc ggctacagga tgatgtcatc atgaaaaaca agccgctcgc 3010741 gtttcagata tgggttgtca tatccggcat cctgttagcg atatcgattt tactgcttgt 3010801 gttattttca aacacgctgc gagatttttt cactaatgaa acgtatacga cgattgaaaa 3010861 tgagcagcat gttctgacag agtaccgcct gccaggttcg attgaaaggc gctattacag 3010921 cgaggaagcg acggcgccga caactgtccg ctccgtacag cacgtgctcc ttcctgaaaa 3010981 tgaagaggct tcttcagaca aggatttaag cattctgtca tcttcattta tccacaaggt 3011041 gtacaagctg gctgataagc aggaagctaa aaagaaacgt tacagcgccg acgtcaatgg 3011101 agagaaagtg ttttttgtca ttaaaaaggg actttccgtc aatggacaat cagcgatgat 3011161 gctctcttac gcgcttgatt cttatcggga cgatttggcc tataccttgt tcaaacagct 3011221 tctgtttatt atagctgtcg tcattttatt aagctggatt ccggctattt ggcttgcaaa 3011281 gtatttatca aggcctcttg tatcatttga aaaacacgtc aaacggattt ctgaacagga 3011341 ttgggatgac ccagtaaaag tggaccggaa agatgaaatc ggcaaattgg gccataccat 3011401 cgaagagatg cgccaaaagc ttgtgcaaaa ggatgaaaca gaaagaactc tattgcaaaa 3011461 tatctctcat gatttaaaaa cgccggtcat ggtcatcaga ggctatacac aatcaattaa 3011521 agacgggatt tttcctaaag gagaccttga aaacactgta gatgttattg aatgcgaagc 3011581 tcttaagctg gagaaaaaaa taaaggattt attatattta acgaagctgg attatttagc 3011641 gaagcaaaaa gtgcagcacg acatgttcag tattgtggaa gtgacagaag aagtcatcga 3011701 acgattgaag tgggcgcgga aagaactatc gtgggaaatt gatgtagaag aggatatttt 3011761 gatgccgggc gatccggagc aatggaacaa actcctcgaa aacattttgg aaaatcaaat 3011821 ccgctatgct gagacaaaaa tagaaatcag catgaaacaa gatgatcgaa atatcgtgat 3011881 caccattaaa aatgacggtc cgcatattga agatgagatg ctctccagcc tctatgagcc 3011941 ttttaataaa gggaagaaag gcgaattcgg cattggtcta agcatcgtaa aacgaatttt 3012001 aactcttcat aaggcatcta tctcaattga aaatgacaaa acgggtgtaa cataccgcat 3012061 agcagtgcca aaatagactg tagatgtttt gcagtctatt tttttatgtg aaagaatagc 3012121 cgttaaaatc tctgtaattt gttttgagcg gctgtttgca ttgatgaacc cattttttct 3012181 ctgacaaggt ctgcttcgga tatttgactt tctccacttt gattcctctg tttcgcaagc 3012241 ggctgatcat ttcgtccaat tctctcattc tagattcacc ctttcgcttg agctttgacc 3012301 attcggtcat ctcaatttat aatataaata atacatgata aaaaaacaag ttacaataag 3012361 gttaatttta taacagacgg tgtgactata tggtcatatc ctagcaggcc tccgggctcc 3012421 gaaagggtgg aaccattgaa ggaaaaagaa aaactgatta ttgaaacagc cttaaaacta 3012481 tttgcccaaa aaggatacaa ctcaacatca gtccaggaaa tcgcaaaaga atgcaaaata 3012541 tctaaaggcg ctttttatat ttattttcct tcgaaagaag cgcttcttct ctctatgctg 3012601 aactactatt atgataaaac gtttacccga attttaaata ttaaaacgaa gggcgacagc 3012661 cccagaacgg cttaccgtaa acagctgacc gtcctctatg aaaacattct tgaacacaaa 3012721 gattttatca gcatgcagtt gaaggagggt tctctgcctt acacagaaga agtggagcaa 3012781 tgcgcaaaaa aaatccgcca gtcctcactt caatttcata tcgacagcct gctgaacatc 3012841 tatggaaaaa aagcggaacc gtacactgct gagctttgtt ttttaataga gggcatcagc 3012901 cagatttacc tggaatgcat gattttgctc gggtacactg tgaagccgtc tcaattagct 3012961 gatatcatta tgaatcgaat tgatgatatg gtaaaaggca tgtctgaacg aaacgataag 3013021 cctttcatca cattggaaga ggcgagctct ttattcggac ctcttacgca cggacggcct 3013081 gacccgctga ctgaatcaat tgtgaaaagc ctacgtgaca aaattaacag cttaaacaca 3013141 aactcctctc ttgaattatc ggagagcttg gacatacttg aagcagaaat gaagaaaaaa 3013201 acaccgaagc tggcgatcat aaaaggaatg attcataatc tgacggagtc tgaagctctc 3013261 gccaaagatg cggaacagct taaatattta ttaaaacagc aacatattta gaagaacggc 3013321 tgcttaaaaa gcagccgttc ttcctattac gcctttggtt ttaccatgtc ttccggctta 3013381 accatttcgt taaattgctc ctctgtcagc aattcaagct tcaaagctgc ttctttgagc 3013441 gtcaatccct ctttatgggc aagcttggcg attttcgccg cgttttcata accgatatgc 3013501 gggttcagcg ccgtaacaag cattaatgaa tttgacaggt tttcctgaat ggtttcttta 3013561 ttaggctcaa taccgacagc acatttatca tggaatgaat tcatgccgtc actgagcagc 3013621 tgcacagatt gcaggaagtt gtaaataata acaggcttaa acacgttcag ttcaaagttc 3013681 ccctgactcg ccgcaaagcc gattgtcgca tcgttcccca tgatttgcgc tgcgatcatt 3013741 gttaacgctt cgctttgtgt cggattgact ttaccaggca taatagagct tcccggctca 3013801 ttttcaggaa tgacgatctc cccgatgccg cagcggggtc cgcttgcgag ccatctgaca 3013861 tcgttcgcga ttttcattaa gtcagccgca agcgctttta atgcgccatg cgcataagtg 3013921 atttcgtcat ggcttgtcag cgcgtggaat ttattcggcg agctgctgaa cgtttggccg 3013981 gtcagcttag tgatctcttc tgagacaagc tctccaaact ctgggtgggc gttgataccc 3014041 gttccgacag ccgttccacc aattgcaagc gcacgcattt tatctgtcgc ttccaaaatc 3014101 atttccttcg aacggtccag catgtgaacc catccgctga tttcctgtcc gagggtcagt 3014161 ggcgtagcat cctgaagatg cgtgcgtccg attttgacaa tatcattgta tgcttttgct 3014221 ttttcatcca gtgtattgcg aagctgatca agcgccggca caagctgctc gtaaacagcc 3014281 aaaacagcgg caacatgcat cgcagtcggg aatgtgtcgt ttgagctttg gcttcggttc 3014341 acgtcatcat ttggatgaat cgtttgatca gagttcttct cttttaataa agcagtcgca 3014401 cggttggcta ccacttcgtt catgttcata ttgctttgtg tgccgcttcc ggtctgccat 3014461 acgacaagcg ggaagttgtc atcgtacttg cctttgagca catcatcaca aaccgctgca 3014521 atcgcttctg ctttttcagc gtccagattg ccgaggcgtt tattagctag agcagtgctt 3014581 cgttttaaaa ttgcaaacgc cttcacaaca cgcatcggca ttttttcaga accgatctta 3014641 aagttctcct tgcttcgctg tgtttgggcg ccccaaaatt tatcagcagg aacttttact 3014701 tctcccatgg tgtctcgttc aattctgtat tccatttatg tatccctcca taacggttgc 3014761 ttcaatagat cataattcgc caatgacaca aaaaatcctt tttatttttc gatcttggca 3014821 gattttaatt ttaattcaag atatacgcgg gaatcctttg aatatttgta ttttggattt 3014881 gtcctgccgt actcctttga tgtataagag acatcataat gctgttcaaa tgatctaatg 3014941 agctgttcaa tttcttcttg ttttccagct agccttacct gtgccacttc gtatcctccg 3015001 ctttcataaa aaaacttact ccatgaaata ctctaacaca gtatatcatt tttttaacag 3015061 gaaaagataa cctctactaa ggttttggat aagaggtgac ctcattggaa caaacagagt 3015121 ttaaggaata tatacacgat aatttagcat tggtgctgcc aaaattaaaa gaaaacgatg 3015181 atctggtgaa aaacaaaaaa atgcttgcga acggactggt tttttactat ctctatttca 3015241 gtgaaatgac tgatgagaat aaggtgtcag aagccattaa aactttgatt aaagatgagg 3015301 agaccttaac gcttgaccag gtcaaaaaac gccttgacca gcttgacgca agacctgttg 3015361 aaactgcaaa aaaaacgatt gaatcgattc tcaacggcaa ttgtgctgtg tttatcaacg 3015421 gattggataa agcctatatt ctgaccacag gaaagaaaaa aacaagaagc ctgacagagc 3015481 cgacaactga aaaagtggtt cgcggcccaa aagtagcgtt tgtagaggat attgatacaa 3015541 atctcgctct gatcagacaa agaacctctc atccgaaatt gatcaccaaa aaaatcatga 3015601 tcggcgaaaa caagctgaag cctgcagcca ttatgtacat tgaaggcaaa gcaaaaaagt 3015661 ccgtcataaa agaagtgaag gcgcggctta aaaatatcca gctggaagat atccaggaca 3015721 gcggaacgct cgaggagctc attgaagata ataaatattc accatttccg cagatacaaa 3015781 atacggaaag acctgacaaa gtatcttcag ccctgtttaa cggccgtgtg gcaattttgg 3015841 tcgacagttc accatttgtg ctgctggtgc cggtttctct cggcatcctg atgcaatccc 3015901 cggatgacta ctatgaacgc tggatttcag catctcttat ccggtcgctg cgctttgctt 3015961 ctatctttat caccttgttt ttgtcatcga tttatataac acttgtttcc ttccatcagg 3016021 ggctgctgcc gaccgcactc gccgtcacga tttcggcgaa cagggaaaac gtgccgttcc 3016081 ctccgatatt tgaagccctg ctgatggaag tcaccatcga gctgctaagg gaagccggac 3016141 tgcgactccc caatccgctc ggacagacga tcggcctcgt tgggggcgta gtcatcggac 3016201 aggctgctgt agaagcgaat ctcgtcagtt cgattttggt cattgtcgtc agtgtcattg 3016261 ccctggcatc ctttaccgtt cctcaatacg gaatgggtct gtctttccgg gtgctgcgtt 3016321 ttatttcgat gttttccgcc gctattttag ggctatacgg cattatttta tttatgcttg 3016381 tcgtttatac gcacttaacg agacaaacga gctttgggtc tccgtatttt tcgccaaacg 3016441 gattctttag cctgaaaaat acggatgact ccattatccg tctcccaatt aaaaacaaac 3016501 caaaagaggt gaataatcca aatgagccaa aaacagactc cactgaaact taataccttt 3016561 caaggtattt ctattgttgc aaatacaatg cttggggccg gacttttaac attgccgcga 3016621 gcgctgacca ctaaggctaa tacgcctgac ggctggatca cgctgatatt agaaggtttc 3016681 atttttattt tcttcattta tttaaacacg ctcattcaga aaaaacatca atacccttca 3016741 ctctttgaat atttgaagga agggcttggg aaatggatcg gcagcatcat cggccttttg 3016801 atctgcggct atttcctcgg cgtagccagc ttcgagacac gggcaatggc tgaaatggtg 3016861 aagtttttcc tgctggagag aaccccaatt caagtcatta ttttaacgtt tatttgctgc 3016921 ggcatttatt taatggttgg gggcttaagc gatgtgtcgc ggctgtttcc cttttattta 3016981 acggtaacca ttattatttt gctgattgtg ttcgggatca gttttaaaat ttttgatatc 3017041 aataatttgc gtcctgtttt aggcgaaggc cttggaccca ttgcaaactc ccttaccgtc 3017101 gtttccatct cttttttagg aatggaagtg atgctgtttc ttcctgaaca tatgaagaaa 3017161 aagaaataca cgttcagata tgcgtctcta ggatttctga ttccgattat cttatatatc 3017221 cttacgtata ttatcgttgt cggagctttg accgctcccg aggtgaaaac gctgatttgg 3017281 ccgactattt ctctctttca gtcctttgag cttaaaggca tatttattga acggtttgaa 3017341 tcctttttac tggtggtctg gattatccag tttttcacca catttgtcat ttacggatac 3017401 tttgccgcta acgggctaaa gaagacattt ggattatcga ctaaaacaag catggtgatt 3017461 atcggcataa cggtctttta tttttctctc tggccggatg acgccaatca agtcatgatg 3017521 tatagcgatt atcttggcta tatttttgtc tccctgtttc tgcttccgtt cattctcttt 3017581 ttcattgtag ctctcaagag gaggattaca acaaaatgaa aatccggatt ttatgtatgt 3017641 ttatatgcac cctattgctg tccggatgct gggacagtga gaatatcgag gaattaagct 3017701 tagtgatcgg aatagggcta gacaagcctg acgatgaaaa tttagagctg acacagcaaa 3017761 ttctcgtgcc gaaaataatc agcgccaagg agggctcttc atctgatccg acacagcttt 3017821 ctatcacaaa gggtaaaact gtccatcaaa tgatgagaac ctctgcatta aagcataagc 3017881 ctacgttttc acagcatttg cgtctcattc tgctttccaa aagcgtgatt gcggatcaaa 3017941 ttggaatgga cgccattatt aaccagtttg tcagagacaa cggaacaagg aggagttcct 3018001 acgtctttat caccaacggc cgaactaagg atatatttaa catgaatgat gaaggcgaac 3018061 ccgcatccaa cgtgatatat gatctgacag agaataataa ggtgacgatc agaacgatgg 3018121 agccagttac attgggggag atctcagaac acttaacctc tgacgattca ttcctcatcc 3018181 ctcatgtcgg taaggaaaac ggcaagctcg cgataaacgg agcctctatc ataaaaaata 3018241 aattatggca ccgggacctc accccgattg aggttcaaaa tatcagctta ttttcaggca 3018301 ctgtcgaggg aggcgtcatt gacttgaagc gcgatggcca tctcttttct tatgaagtat 3018361 attcaagcaa tcggaagatc aagacggcat acaaggacgg aaagttcaaa ttcaccgtta 3018421 cccgcaatat tgaaggtcgt ctatctgagg actggaatcc caatgaagac tcgtttaagg 3018481 attcatatat taaaagtatt gaaaagacag tcgaaaaacg agtacacgaa acagtaacgt 3018541 catttattac agagaagctg cagaaagaga tcaaagcgga cgtaaccggg ctgggaaacg 3018601 aggtcagaat tcattatcct caaaagtgga aaaagatttc aagaaaatgg gatgatgatt 3018661 atttcagcaa tgcggaaata gactaccggg tcaatgtgat tgtcagagac ttcggaacga 3018721 aaggcgcaaa caaatagcag ccgcctaatt cacgagatga tttcggtgtg cgtacaccgc 3018781 cgcctgcgtc cggtcactga catccagctt tgataaaata ttcgtaatat gtgttttgac 3018841 tgttttaatc gtaataaaca gttcctcgcc tatttctttg tttgtctttc cttctgcgat 3018901 caggcagagt atttcgagct cccgttttgt aagcgattca tgcgggagcg cgttttcacc 3018961 tgagtggcgc agcctggata atacttttcc cgccactttt gactccagct tcggctctcc 3019021 cttgcttgcg gcgcggatgg catcggcgat ttctgccgct tttgaggttt tcaacagata 3019081 gctgagcgcg ccagcttcaa taaccgggta cactttgtca tcatcaatga agctagtgag 3019141 cacaataatt ttcgggtcgg aaagctcccg gcaaatttgc tttgtagctt caatgccatc 3019201 catgccctcc atgacaaggt ccattaaaat gacatcaggc gacagttcca cagcaagccg 3019261 aacaccttcg ctgccgtccg atgcttcgcc gatgacttca atatcgggct gcgcctccaa 3019321 aaaagccgcg agccccattc tgaccatttc atgatcatca atcaataata ctcgaatcac 3019381 gttcgttctc tcctttttct tccggaaaaa tcgggacctt cacttcgatt tgagtgcctt 3019441 ttccttctac tgaaatcact tcggcgacac cgccgatttc acttgcacgt tctttcatag 3019501 aattcaagcc gtatgaggag gctttcacct ggtccatttt aaagcctttt ccattatcaa 3019561 tcaccttcag acggagctgg ctgttcttta tgcccagaat cacggttact tttgacgctt 3019621 ttgaatgtct aaatacgttt gaaagggcct cctgcacgat tctgaacaag tggtcttcaa 3019681 cacccttgga tatcgctgtg tcctgtatat cccactcaat atcaatcggc tgcttttttc 3019741 ggaactcgtc caaaagctcc gtaaggccct ccttcagccc ttttccttca agggtaacag 3019801 gccgtaaatg gagcagcagc gccctcatct cattttgggc ttcgcctgcc atatgctcga 3019861 ccatcctgat ccgcttgact gttttgtcat cagcatcctt gacatgttcc agcacggctg 3019921 atgtcatcat cgatatggca aagagctgct ggctgaccgc atcatgaaga tctctggcca 3019981 atcgctggcg ttcttctgag ataaccgact tcttcatttg agcctgccat tccgcacgtt 3020041 cattggaaag tttctggagg gatgcgactt gaagctccac gcgcttcgcc atttcgttca 3020101 gctgatcagc agccaggccg atttcatcat caccgagcgg cggtatccga taagcgaaat 3020161 tgccgttttc aaaggttaaa atggattcaa ttaatgtatc aatccttgtc ttcaaccggt 3020221 tgccgtacat ataccctgag gcgaaaccga cggtcacgct gatcagaagc aaaatcagga 3020281 taaacggaat tccgaaccag cttgatgaca gcaaaacaag cggatcgagc cgatagtaaa 3020341 acatcataaa ggaaatcagg caaacaaaaa ggagcaggct gattcccgtt gtcatgcgga 3020401 tggcgcgcca ttggaggctg gcaagcattt tttttctcat acgtacttca catccacatc 3020461 accgataaat aaggaaacgg acacttttac ccggcgcttt gactcgctaa aatcagttga 3020521 cgcggcatat accttcgtgc ttaatccgct tttcttcgag ccgatcagat taatgtctcc 3020581 tataaaaaca gccgagctga cagccacttc aaggtccgat ggtacataaa tatcaacgtt 3020641 accaatgact ccgctaatga cgattgtact ttctccctcg ggaatcatcg ctttagataa 3020701 atcgattttg atatcaccga taaaaccaga gacatttaaa tcgttcaggt caaacggctg 3020761 cttcatcatt tgcagctcac cgataaaaaa gctgcgcatg tcgggatgtt ttacatcttt 3020821 tggcggctca tgatgttctt ttttattgag attgacctgt ttctcattcg gttcaaatat 3020881 cggcttccct ttgataagcc tgtagccggc gtaaatcaga aatgcggcaa acgcatagcc 3020941 gaataaatta aaggtgatgc tgaagaggtt tttcaaaaat agaaacgcgg caaagatata 3021001 catgacggag ccaagccaat cacgggaata ttttttaagg aaatagccgg caatcagaaa 3021061 aaagagcggc caaaacagca gatcgcctat tccgataatt tgcaaaaaca tactgatgcc 3021121 gaataaagca atgatcaatc cgagaagctg tttttttgtc attcctggtg tccgcctcct 3021181 ttcttctgcc tagtgctacc gtatcgctag atccccgctg tccgttttga tgtcgattgg 3021241 atgccggccg cttccttgcg tgcctgtgat gtgatgctgt tctttatgtc ctttatcagc 3021301 aaatgaatac ggcgaactga cgtcaccgct tgctgataaa gcattgactg caaagctgcc 3021361 attttgggga aggcttacat tagcatcacc gcttgtcagc gtgacagata cgggaccggt 3021421 tacctttttc aatacagcat taaaatctcc tgaagtcatt ttcacatcaa gagagcctga 3021481 tacatgaacc agatttgcgt cccctgaagc taaatcaatg ccggctgttt tggagacggt 3021541 atttgaaatg gaaacatccc ccgatgatgc cttcactttc agatcttgaa tgcggacgtc 3021601 cgtcacgctc gtatttccgc tcgcagatac tgcgttcagc ccggaaagcg caagatggtc 3021661 attcccggcc acagacacgt caccgcttga ggttcgtact gccagatcac ctttataatc 3021721 atacggaagc ctgacgataa gagttgaacg gttaaatcca ttcaaaaatt gaaattcttt 3021781 ttcctttacg gtcagctcca gttttctttt gttttcagta acaaataact ttcctgagtc 3021841 tcctgaaatg cctgccgata tgtcacttcg ttcttccgct ataatccgga catccttgct 3021901 atccgactca atgaccatgc tgtcaatgtc ccgcggcgat gcgctggctg aatcagcttc 3021961 tgtgccattt atgaaaccta ggcctgcagc aaacacatct tttacgacga cggcgaaaaa 3022021 aaccagaata ccggcagtga tcaacagttt gccaagcatt tttttcattc ggtttcatcc 3022081 ttctcattca ttctattata aaggaaaagc ttgcgaattg atacgtgcgg aagggaagga 3022141 cttgaccgca aatccttccc cgttccgctt attcatttgc cgcttttgtc tggtctgatt 3022201 tttgcagtga aagtgtccgc attttttcaa tctccgcttc cacatcgtct gcgaattctt 3022261 tacgtgtaag ttctgtgccg gcttccgctg actttgaata attcgcgcgg atttccattt 3022321 cttcaatacg attttcaata cgtaaaaatt cacgatacgc gctttcactg tcaattttgt 3022381 caaatgtcgt attcatatgc tctttagctt tcgccgcatt tgcccgcgca atcagcgcct 3022441 gttttttatc ctttacgtcc tgaagctttg tttcaagtgc agccagctgc tctttcagat 3022501 cagccagctg actgtttgcc tgttcatagg aagctttatg ctcagccgcc ttcccttcta 3022561 aatacttcat ttcagtcagc gcctttttcg ccagttcttc ttcacctgcg tcaaatgcga 3022621 gctgtgcctg atttttccgt ttgccagcca cttcagcggc ttcttcatat tttttcttaa 3022681 attgataggc aatcgtgtgc tgtttcacaa ttgtttgctt tgcttttgcg atgtcgcttt 3022741 ccatatcgcg tacatattga ttcagcatca cctttggatt ctccatttta tcaagtcctt 3022801 catgaactga cgcaacaaac atgtctctga ttctttttaa taccatacct gattcctcct 3022861 aatatattga tattattttt tcttcaaaaa ttcttcccat tcgtcatcaa agtgagattg 3022921 gtaggcagca gaagccggtt caggatcaaa agatgataca ccgttatcag ctgatccgtt 3022981 tttcatcagc ttccagccgt aatacaccat agcggccgcc aatgcgattc cgacgacaaa 3023041 cggaagtgag cagatgagca taatggctcc gataccgccc acgatgattc ccgtgatggt 3023101 ttttcccgcg gcaaaccttt tgattcctgc gtatgtcatc aagctcccga tggcgagcgg 3023161 gatgataaag ccgaagcttc ctcctccaaa aaagacggag atcccaaata caattaataa 3023221 gaatccgcct attgttttct tgtttatttt catgcagatc ctcctttcgt tttccttgtc 3023281 ttcatcttat acaagttgga agatatgcaa aacgaatcag agattgattt ttatataaga 3023341 ccggagtcgt atctcgcacc ggacccattg gcacaaaaaa acgccatgca cgaggcatgg 3023401 cgttttaaaa ccctttacag atgaacactt gcttcccttt ctttaattag gtcggacctt 3023461 tctgctttgg ccaattttgt aaacagcaag attccgatac ccgcaataat ttcgacaatc 3023521 ccaccgacag cgatcacttt acctgagccg aaagcattag cggcataccc gcaaatgaca 3023581 gctccggcag ggatcgaaat atttgagatc atatgtataa cggcgtaaac ctgcggctga 3023641 tcctcactat ccacagacgt ctggataatc gtgtactcag gaacattaac agcactgact 3023701 gcggcaccaa aggtaaaagc agcgaaaaag acgagcggca aaaaggtatt catcccggta 3023761 ataaagaaag caaatccttc aataatgccg gcagtgacga ataacaagcc gtacctgttt 3023821 accttgactt tcgccagcac aaaccctaat aaaaacgcgc ccgcggcggt ggtggccttt 3023881 aaaagcgagt atacgatcgg ctggccgttt aaatcttccg caacgtatac ggcagagagc 3023941 gcttcccatg gggcagccgc gaaattcata aagatacagt aaatggcgag cggatataaa 3024001 atctggtgtt ttctgacgag cctaaagccg cgtttcagtc ttccgatata tgtgcctctc 3024061 tgtgtaacaa ccgcagactc tgattgagat tcaaccgcag tgtacttaat aaaaagaacg 3024121 agaaaacctg acaccaaata gagcacaagt gcgataagca tggtataaga aggactaata 3024181 aatgtaagaa aagcgccgca taatgtgaca gccccaagcc ggacaatttg agcggaggat 3024241 tgcagcacag cgtttgcttt ttgaatgccc tgttcattga cgatttgagg aatcaaagcg 3024301 atagaggcgg gattgtaggc agctccagta gctgaatgca caatcataag cgtcatgaca 3024361 aaccacagcg gagagaagcc cgcaaaatga catagaggga taatcaaaac aatcgccgcc 3024421 cttgtcagat ctgaaaagta catccaaaat ttcagcgtgg tctgtttcat aaaaggcccc 3024481 gtcacaggcg ccagaacggc ttccggcaaa aacgtgacag caatcaataa agcagtgccg 3024541 atcgcacctt tgccgtcata aattaaaaac cataatattg aattaaatgc gaacatatcg 3024601 ccggatatct tgactattct tgagaaaaac agataattga aatttctctt ccagatgcta 3024661 tcactttcaa ttaaattcac catccatcag agccccccgt tgcctatttt ttacatctat 3024721 ttattacaat atctcatttt tccatttttc agtcaataat tcataaggtt cattttttgt 3024781 cgtaaaatgg gaaattgaca gagtgaaaaa caaaaaaagc cggcatgtat ttgaacacgc 3024841 cggctttcct tttcactttt tatgattcgc tgctgtttcg gtcccgaaac acaatggcac 3024901 ttctttcata ttctacatcg ccaataccgc ttcttgcatt cacaacccgg gcggcggcaa 3024961 agaaataatc ggacagacga ttgagataac gcagcactgt ttcatgaatc tcctccgatt 3025021 tcatcagcgc caccactctt cgttctgccc gccttgtaat ggtgcgtgcg atatggagaa 3025081 gcgaagcaca ctttgatccg cctggaagaa taaatttctt cagttccggc gcttctgctg 3025141 tataggcatc aatgcgcgtt tctaaaaagg aaacagattc ttccgttagt ttatagtctt 3025201 ttctttctgt gacgattgcc agatcgcctc cgcagtcaaa cagctcatgc tggatggtca 3025261 gcagctcggc tgtcagatct tcaaagccgg gctgcccgga aagctctgcc aaagcaagcc 3025321 cgataaagct gttaagctcg tcaatcgtgc cgtagctttc gacgcgtagg ctgtccttgt 3025381 ccgttctgcc cccgactaag cccgtttgtc ccttatcgcc tgtttttgta tatagtttca 3025441 taccctgaat ctcctttaca gacttattca aacaactcag cagcctcttt tatacattca 3025501 gctgtccctt tctttatcaa ttggttcagc cgctgttcta tgttttctga ttgctgagtt 3025561 tgagtcgcgg cgatgagaat atcacctgtg cctcctccgt ctcccagcac tttcgtccgt 3025621 tctgcttcgg cagccataag agctttgatg aagaattgat ctgccgcata gccgttaatc 3025681 aaaatccaaa tcgaaaagcc ggtctgaacg catatgaaaa cggataactc tccgtcttca 3025741 tatgttcgat acacgaaacg gtcaagtctt tctgaagaag ccatcgcaca cgtctcctgc 3025801 agttgaaaac cgctttctga aagacaggcc gtaagtcctt ctatcggatc tggctgatct 3025861 ggcagccgtt tatggatcag cgtcctgctc cacgaaaacc ctgcaccgat aggcgtggag 3025921 gacaatgttc gaagcgggat ttccgtttgc agaagaatgt catcacgccc cgcttggagc 3025981 aatgcttcaa atgggataga ctgccgcttc acgctatctt tttcaggctg aatcacaatc 3026041 atcggtttag gtgagctttg atgaaccaag gcggtgacat ctgtatcgta caccgccttt 3026101 atgctttgtt ctgtaacagc atattccggt ttttgcttag gcccggcggt accgtttttc 3026161 ataaacatga gcccatcaca gtacaggctt gcggtgttca gatcatgaaa aacgctgaca 3026221 gctgccaatc cgctttctct cgtcaggcgt ttgatcagat caagcaggtc tttttgataa 3026281 gccagatcga gaaaattagt cggctcgtcc aaaaataaaa tacgcggctg ctgcgccaaa 3026341 gcttgtgcca aatacacccg ctgctgttcc cctccgctta gttcgcgaat cggcttttgc 3026401 gcaaaatcgg ccactcctgt ttgctccatt gcttcctgta caatggcttc acccttttca 3026461 gtctgctgtc tgaacagccc cgtttggaat ggatatctgc caaaggctac agtttcttcg 3026521 acagtaaagg tgaaggcttg atccattttt tgcggcagga cagccatgat ttgcgccagt 3026581 tccttcggtt tatagtccgc cagcagtttt ccggccagat aaaccctgcc tttcttggcc 3026641 ggcagcgtac ctgtcagcaa gtgcaaaagc gtggtttttc cgcttccatt agggccgaga 3026701 attccaagaa attctccctt ctccactgtt aagctgacat tgttgattag gcggctgtcg 3026761 ccgtatcctc ccgacagccc ttctgccttc atcataagct tctccccccg cgatgctgcc 3026821 gaattaaaat aagagcgaac acaggcgctc ccgccaagga cgtaatgatc ccgatcggca 3026881 gttcaatcgg ctcaatgatg gttctggaaa gcagatcggc taaaacaaga aaccctgccc 3026941 caagcaaggc ggacaacggc agtaaatgcc gatggtccgt tccccacaaa agccttgtga 3027001 tatgcggaat cacaaggccg acaaagccaa tcgtacccga tactgccaca gcgcttcccg 3027061 tcaaaagaga tccggctatt aaaatcatca tcttcctctg ctgaacgctg actccaagaa 3027121 gctttgcttt atcttctcca tatgtcatca cgttcagttc ccttccgttt ataatcaata 3027181 aaatggttcc caaaagaaaa aacgggagaa acaaaataac atagctccag cccctcattg 3027241 agacgctgcc aagcagccaa tgcacaatcg gaagcaggtt gtctcctgtc aaggcgatga 3027301 taagagaaat aaatgcgcct aaaaaagagt tggtgatgac accggtcaaa atgagggtgg 3027361 aaacagacat cgaagcatga acgaggcggc tgaagaaaag gaccgccgcc atcgtggcca 3027421 gtgccgcggc tacactcaaa accgggagtg taaaccctcc gatgacagga aggtgcaaac 3027481 ctaagaacag agtcacaaca gctccgactg aagcaccgga tgacacacct agcgtatagg 3027541 gatcagcaag cggatttttc aacaatcctt gaaaagcggc ccctgcaata gaaagagccg 3027601 cccccacaag ggcggccagc acaactctcg gcagtctgat attcatcata atattagtgt 3027661 acatcggatc atcagaaccg atagagccgc cgaaaccttg atgccaaaag acacgaaaaa 3027721 cagcgggaat aggaatatgc aggctgccgc aagaaattcc taagatgatg ctcacggcta 3027781 aaaatgagaa accaatgata tatgcggcat aacgattatt ccttaaacgt atccgggtaa 3027841 atgctttccg caagttcttc gaccccttcg atcagacggg gaccggaacg tgtcacaaga 3027901 tcagggtcca catcatatac acgatgatgt ttcacagcat tgatttcgct ccagccatcg 3027961 cgtttttcca cagctttcgc tttcacaccg tccgttgtaa caattgcatc aggattgagt 3028021 tttacgatcg cctcgtctgt catttgcacc catcctgtct gatccgcagc tgcgttttta 3028081 gcatggatga catttagcat ttcattcata aacgtatctt ttccggttgt ataaatgtca 3028141 ggatcaggag aaacctcgat aaatacgctt ttctcctcgt cttttgaaat ggttttcgct 3028201 ttttcttgaa tatcctttag atctgatttc atgcttttca cgagctgatc ggcttttttc 3028261 tccgccccgc cagcttctcc gatcatttcg attgatttgt acacctcgga gaatgattgt 3028321 gcatcattga cagtcagcac tgtaatgccc gcgtccttca gctgtttgat ggcatccgct 3028381 gatgctgaca tggaagactc atgggccaga acgagatctg gttttagaga aatgactttt 3028441 tcaacgttta cattcatatc tccgactttc tcaacctttt tgacttcctt tggataggta 3028501 tcgtttgtgg tgacaccgac cactttgtca ccaaggccga gtgcgtatgt aatttctgtg 3028561 ttgctcggca ttaatgaaac aatctttttt ggctcttttt tgatggttac atcttggttt 3028621 gacgcatcat caatggtgac agggaacact tctgtttttt gttttgcctt tgaatccttc 3028681 tgatccgcag gattgccgca gcctgccagc ataacagcag ccaacagaag cgcagcccat 3028741 atcccggctc gttttttcat aatcttttcc tcctaaacga actaaaaaag catctctacg 3028801 acggtaaaga tgctgtaaac aacacaaaaa agcctattgt ttacacatca tctgtcctcg 3028861 cagaattcgt gctgatcaaa caggcaggta tcctggctct tggcgcttgg ccaattacag 3028921 tggcgggacc gcaccggctt ttaccggttt cccttttaag ccggctgttg ttcacggacc 3028981 ggcacctatt tgacattcgt atccgttttt cggagtaatt atactatatg actgacaggc 3029041 ttgtatatgt gtcctgaatg acttttcccc atattgtgta tggaagcaaa atcctcgtaa 3029101 acactaaatt tgatcttgta tacttaatac catcatctat caaaaggaat gattcttatg 3029161 gatttacagc taaaagaaaa actcgtctta atcaccggct cgacgtccgg tatcgggaaa 3029221 gccgccgcaa aaagctttct gcaagagggt gcggcagtca ttgtcaacgg acgcaaacag 3029281 gagactgtcg atcgcaccat tgaagagctt tctggctatg gaacagtgca cggtgctgct 3029341 gccgatttgt caaaaacaga tgaagcagcg gcttttatcg aaaaagtaaa tgaaatcggt 3029401 gatatcgata tccttgtcaa caaccttggt ttcttcgagg taaaagactt cgccgatgtg 3029461 acagatgaag agtggaatca atatttcgaa gtgaacgtga tgagcgccgt tcggacaagc 3029521 cgtcacttcc ttccaaaaat gcttgccaaa aacagcggcc gcattttaaa tattgcaagt 3029581 gaagcaggcg tcaaaccgct gccaacgatg attccatact caatgacaaa aacggcactg 3029641 atcagccttt caagaggaat ggctgaaatg acaaaaggca caaatgtgac ggtcaactca 3029701 gtgctcccgg gacctacttg gacagagggc gtggcctcct atatggaagg cgccgcacaa 3029761 gcagccggac aggatacaga tacatttatc aaagactatt tcaaggtcaa tgagccaacc 3029821 tcacttattc agcgatacgc gacagcagaa gaagtcgcca acacaatcgt attcctcgcg 3029881 tctgacgccg catccgccat taacggcacg gcacagcgtg tggaaggcgg cattatccgt 3029941 tctctgtagt ataaaaaaac gcatccgtgt ttcggatgcg ttttttttat acgtctccag 3030001 caaatggtac cggctgatat ccgcctgttt ccagttgtgc tgaaaacaac cctccagcgt 3030061 gaggctgctc gtatctctct ttttctgtca tttgttctgt tgccgttgta atgtaaaggg 3030121 tttttaagtc tctgccgccg aacgcgcagc acgtgacata tttagccggc acgctgattg 3030181 aattgatttc ttttttctga aacgggtcaa tgtgaacaac gcggctgccg ccaaacagcg 3030241 ccacccacag catgccattt tggtcaattg tcatgccgtc cggcaatccg tctgactgat 3030301 caaaacgata gacaggttct ggattcgaaa catctccgct ttgaggatca tagctgtaac 3030361 gtacaatctc ctgggtcggc gtgtcgatgt aatacatcaa attccgctcg cggtcccaat 3030421 ccaaaccgtt tgaggtggag acttgatcct tgattttgac aagactgccg tctagattca 3030481 aacggtacag cgacgcctgt ttttgctcgc cttccatgct cgtcgtcccc gcccaaagcc 3030541 ttccgtacgg gtcacattta gcatcattaa atctcaggct ctcatgcatg tccttcggct 3030601 gtttaatttt ttccaagctg tcatcccgaa gatgatacag gtaaaacccg tccttcatcg 3030661 tcataatcag ttcatccttt gaatatttcg caagcgccgt cacaaaggat ttgaatttga 3030721 ttgatcggtt gattttttct tcagggtcaa agatgtggag ctcgctcccc aggatatcaa 3030781 cccaatataa gcggccgttc tcttcatccc ataacgggcc ttcaccaatc actgcccgag 3030841 tgtctgcttc caatactgca tccatgtgtt acacctcttt agcttcagtc tatatattgt 3030901 tattcccggc aaagaggtgt ccaaaccact tgatgtttat tgttttttaa aaaggatggt 3030961 aatgaccgtt ccaatgttcg ttctgctgtt cacatggatc gttccgttat gcagatggac 3031021 aagctccttg gcaatcgcga gcccgagacc cgttccggca gttgaatctt ttgtgttcgt 3031081 ccctctgtag tagcggttaa acaaatgggt gatcgtttct tcatccattc ctttcccatt 3031141 gtccttcact tttaaagaaa tatgattttt tgtttgctcc agaatgactt gaatctctgt 3031201 tcctttgccg ttgtgcttca cggcattccc aaggaggttt tctaatatgc gcctgaacca 3031261 cgcttcatca agggcaaatt caatatgctc ttctttggat acaaacgaga tatcatagcc 3031321 ttcagaaaac ggatttttct taaaatcctc aatgacattt ttaaaaaacg ggataaggct 3031381 agtgagcttt ctctcaatag gaagagcatc atttttcagg cgatacgtta aatttaagtc 3031441 ttcaatcagc ttagacatgt attcagattt ttctctgaca acctgcccca tttctttcac 3031501 ttcttccggc gaccagtcat actgcttcga ctcgagcatc atgctgtagc cgtaaatgct 3031561 gctgagcggt gtttttaagt catgtgacaa accggcaatc cattcttccc ttgtcgcctg 3031621 gattttttct ctgtttcttt tatcccttct cagcgtttca gtcagctgat ccattgattc 3031681 aaatatctca ccgaagaagc ggtacggctg tttgattttt ccctttttat ttttgctgac 3031741 aggacggcct tcccggtttc tgggctcctc aagcttccct tttgacagat tgaccagcca 3031801 tctaatcgtg tgaaaaatcg gcagcccgaa tcggaacata taccaaacgg tcatccaaat 3031861 gatatacatg aacaaaacgg ccatcacgag aaacatcgct tttaatacaa ccttcaggaa 3031921 tgatttgtta aactcctgat cggttacata gactgggttc ggcaccgtag cgaccatcca 3031981 tctgtcttta ttgaggatct taacggaaat ttcccgctta tagttccaag gcttagagct 3032041 gtatttaagc agctccagct ggttcatcgt ttttctctcg ctttttgtgc tgttgatgct 3032101 gtcgagaatc tttccattgc tgtctaacag gtaaatggcg ccttttttcc gtttaatata 3032161 gtcgatggta ctagacttat agtgcgctag tgagtctatc ttttgttcac gcttttcaac 3032221 ggaagtcagg agctgttcac tttttgattt ccagccggac aatagaagat acgacttatc 3032281 ttcaatattg atggcccaat aattcagttt atagttatga agctttttgg ttttataaat 3032341 agacaaaagc tctttcttgg tataggtgcc cggcacgtct tttggcacgc cgtaggaata 3032401 atcagtgttt ccttccgaat caatgatttg catccagccg tgctgtttat caacagattt 3032461 cttcaggaaa ttatccactt cccatgtccc gtcttcgttt acatcgagat atgcctcaag 3032521 tgtgtcggtc gttgctttcg tcagccctga attggattcc gcatcgctaa aacgggcgtc 3032581 taaatagaaa aacgatgcaa caagcataac cgtaagcagc aggatcacaa tcagcatctg 3032641 gccgaaaaag tgaaacaaaa acttccatct taacctcatg accgcttgcc ttcaggattt 3032701 gggataaaac gatagccgag acctcgaacg gttacaatat actccggatt gctcggatcg 3032761 cgctcaatct tctccctaag cttgcgaata tgaaccatga cggtgttgtt gtcaccgtag 3032821 gaaggatagc cccatacttt ttcatatatt tgatctttgg aaagcaccac gttagggtgt 3032881 tcacaaaaat actgcaaaag ctgcagaagc tgggctgaac aggcaacggc ttccccgcct 3032941 acgatcaact cggcattttg cggagaaaaa gtaaagtaat catatgtgta ggtttgattt 3033001 gaactcgttt ctttcgattg atatgtacgc ttgagatgcg ctctgatccg cgccgctaat 3033061 tccagcggat taaatggttt tgtgatatag tcatcagctc caaccgcaaa gcccgataat 3033121 ttgtccgcgt cggatgatct tgccgtcagg aaaaaaatcg gagcgtctga atactctctg 3033181 atcaatgtgc aggcttcaaa accggacatt ccgcccatca tgacatccag cacaatcaag 3033241 tcaaccttat tggccttcac aacgggaatc gcttcttctg cgcttgccgc atccagtata 3033301 tttcgataac cttctttttc gagaacgcgt ttgatcatgt ccacaatcgc tttctcatcg 3033361 tctacgatta aaattgacgc attttccact tttatgttcc tttctgtcac tgtttttttc 3033421 atcttatcat tatatcgttt atttatggta catttttgaa tacattggag ccttggcaaa 3033481 tcaaaacagc aaaaaaggag caaacaagcg ctcccttttg atgttttttc atatgaaaat 3033541 attatgagtt ctcatctacc atgtacaaaa taaactccca aaaccccggt acatcctgac 3033601 ataaaagcat atcagccttt tcaaacattt tgatcttcag ctcttgctct aaatcttctc 3033661 tttcttgata ggacgtattg ctgagttttt ttctgatcat cggtgaaaag catgcaatca 3033721 ggtgctcaat gtcataagtc tcgtcttttt gtttcttttt ttgttcaaac tggccgtcca 3033781 cagcttactt ttcccccttt ttttgcgccg ctaactgctt tctgatattc tccagcccct 3033841 ttttatgaat gttggagatg ttttgtcggg actcccctaa tgaatctgca atctcctgca 3033901 tcgtggcacc gtgaagatag actttcgtca gcacactttt ttgtttgtca gtcagcttct 3033961 ggatcgcttg gtagagctgg taatcctgta catgctggct caaatcatcc tgcctgtcta 3034021 aaaattcttc aaatgcatcg ctacctgttt cggaagaaag ccgatctccc gcctccggat 3034081 gatcaaccgt cagtggatac cgtttttggt ttttgcgaac ccgcttatca aaatcaatag 3034141 aaaagatgcg aatcattgaa ttcatatact tgacgatgcg gatttcttta taaaattgct 3034201 taaatagctc gtccaatgat cttgcatctt tttcgttagg gctttccatt acgtttttga 3034261 acaaacggta atgctgagga ttgctcaaaa aatgcttcac gatgggatgc ttcattatct 3034321 ccttacattt tgaccgtaaa agactttgat agtccatcaa accgcctccc tactaaatta 3034381 aatgaaggaa agcaaaaaaa agtaaactac tactttccgc ctagtgtctt ccaaaatact 3034441 ttgcagcagt ttacgtttta tcggttttcc tcacttacat acatgactgc agaaaaagaa 3034501 gggaggtatt ttcctatgga tcaggttttt atagaggaag tcgtaaaaca gatcggcaat 3034561 ttggggtttc ccgcgctgat tgcaatgtat ctgctgaccc gattcgaaaa gaagtttgat 3034621 caactaatag aactaatgac agaactgaaa gatcatgcaa aaaaataatt tttcaatcga 3034681 agttgacttt tcactggttt ttttcactta acaaaacaga agggaaaacg aaaggccttt 3034741 caccttctct ttctgctatc acatttaaat gtaaggagga aacatttcat gaaaaaacaa 3034801 aatgacattc cgcagccaat tagaggagac aaaggagcaa cggtaaaaat cccgcgcaat 3034861 attgaaagag accggcaaaa ccctgatatg ctcgttccgc ctgaaaccga tcatggcacc 3034921 gtcagcaata tgaagttttc attctctgat actcataacc gattagaaaa aggcggatat 3034981 gcccgggaag tgacagtacg tgaattgccg atttcagaaa accttgcatc cgtaaatatg 3035041 cggctgaagc caggcgcgat tcgcgagctt cactggcata aagaagctga atgggcttat 3035101 atgatttacg gaagtgcaag agtcacaatt gtagatgaaa aagggcgcag ctttattgac 3035161 gatgtaggtg aaggagacct ttggtacttc ccgtcaggcc tgccgcactc catccaagcg 3035221 ctggaggagg gagctgagtt cctgctcgtg tttgacgatg gatcattctc tgaaaacagc 3035281 acgttccagc tgacagattg gctggcccac actccaaaag aagtcattgc tgcgaacttc 3035341 ggcgtgacaa aagaagagat ttccaatttg cctggcaaag aaaaatatat atttgaaaac 3035401 caacttcctg gcagtttaaa agatgatatt gtggaagggc cgaatggcga agtgccttat 3035461 ccatttactt accgccttct tgaacaagag ccgatcgaat ctgagggagg aaaagtatac 3035521 attgcagatt cgacaaactt caaagtgtct aaaaccatcg catcagcgct cgtaacagta 3035581 gaacccggcg ccatgagaga actgcactgg cacccgaata cccacgaatg gcaatactac 3035641 atctccggta aagctagaat gaccgttttt gcatctgacg gccatgccag aacgtttaat 3035701 taccaagccg gtgatgtcgg atatgtacca tttgcaatgg gtcattacgt tgaaaacatc 3035761 ggggatgaac cgcttgtctt tttagaaatc ttcaaagacg accattatgc tgatgtatct 3035821 ttaaaccaat ggcttgccat gcttcctgaa acatttgttc aagcgcacct tgacttgggc 3035881 aaagacttta ctgatgtgct ttcaaaagaa aagcacccag tagtgaaaaa gaaatgcagt 3035941 aaataaaaga cttgcggctt gcagagagca ctcgttctct gcaagccttc ataaggagct 3036001 gaaccagtga aacatcaaaa cccttcaaaa cgcttattgc ggctctccat aaagtacttg 3036061 ctggccgcag cagcagtggt gttgacctat tttgctgtca tctatatatt gttttcttta 3036121 gcgggaacga gctaccgctc agcagctcat gtcctgcttt ttgccgtggt attccttgtt 3036181 ctcggattat gctttgaacc atttgaacgg ctgatgatac atagctttac atttttcaag 3036241 acaggaaaac gtctattcat tctccttgct ggcatcgtac agctgctgtt tttgtggatg 3036301 actgctcata caacagacca attgatcagc gacatctggc tgtccaccac agaagaaatg 3036361 attgtcgcag ccgttttttt gattttagac aaatgcaact cggctcttcc cagctaaaaa 3036421 aagaacgcat tccaattgga tgcgttcttt ttattcatag cgaagcgcgt ctacaggctg 3036481 aagcttcgaa gccttgatag acggaagcaa gccgaagata atgccgactg ccattgaaaa 3036541 gatgagtgct ccgacaacag ctggaatgga gacgataaaa ggcatcggaa aaatgaccgt 3036601 cagcagcttg gcgatgccga agcccgccag cacaccgagt attccgccaa tgcttgtcag 3036661 cacgacagcc tcggttaaaa attgaaataa aatcacacgc cgcttagcac cgagcgcttt 3036721 cttaattccg atttccctcg tgcgctccgt tacggaaacg agcataatgt tcatgacgcc 3036781 gataccgccc accaaaagtg aaatactggc gataccgcca agcagcaatg caaatgactg 3036841 attaaaggac tccacttcct gcgcgatctc ctgaagatcc attacactgt actctgcttt 3036901 ttccagctca gcttctgaca gtccctgatt taaaagatct gcagccatta cacccgcttc 3036961 ttggatatgc tcagaagaat cagcctgcac ggcaatctgc gttggcgcgt caaatccttc 3037021 aataagcggc cacacttttt tcggcacgta caaaaccggg ttcgcatagt cgccttcaaa 3037081 catgctttcc tgttgatttt tttctttaaa aacacccacg accttaaacg gcacaccatt 3037141 catctcaatg cttttatgca gagcttctcc gtctggaaac agttcatctc tgacagcttc 3037201 attgatcatc actacttggt gtgtgctgtt taaatcgttt tccgtcagct ttctcccttc 3037261 ggttattcgg attggaaaca tgtcgaagta atcatcgtcc actccataca cttggggata 3037321 cgaaacgtta gttaaatgaa aaacgctcgc gccttctgac aagtaatata aggataatcc 3037381 tttgaccatc ggatctgatt tgatcgcctt tactgtttct tccgctacag gcggcgcgga 3037441 cgcatacgac acctgagggc cgccgctctc ctcttctccg ccagacggct ggtagacaac 3037501 attgatggcg ttgtttccca tgccgatcat actttgcttt aactgctcac tttggccctt 3037561 cagcattgaa acaatcgcga tgattgccgc tatgccgata atgacgccaa gcattgtcag 3037621 aatcgatctt aatttatgag agaaaatgga ttgaaaggag attcgaatat gttcaagcat 3037681 ggctgatatc ccctctctca tctaatacca actctccgtc tctgataaaa acggttctgt 3037741 cagctttttt ggcgacgtcc gggtcgtggg ttatcataat aatggtcttg ccttcccgat 3037801 gcagttcaga aaacagtgcc aaaatttgtt cacttgattt ggtatcaagc gccccggtcg 3037861 gttcatcagc taaaataaac ctcggctgat tgacaagggc cctcgctatc gccacccgct 3037921 gcttttggcc gccggacagc ttaggcggtt tgtaggagac cctgtctttt aatccgactt 3037981 tttccagcgc ttcatatgcc cgttgccttc tctctttttt cttcacttta ttgtagatca 3038041 tcggcagctc gacattttgc agcgcggtga gacgcggcag caaatgaaaa gtttgaaaca 3038101 caaacccgat tgattcattg cgaatttcgg ctaaagcccc gtctttccct ttcaatatat 3038161 cgatctggtc aagcgtatag gttcctgagg ttggcctgtc caaacagccg ataatattca 3038221 ttaacgttga ctttccagaa ccggaaggcc ccataatagc taaaaactcc cccgcctgaa 3038281 cggtcagatt gatatgtttc aagattggaa cttcttcttt tcccagcttg tacgacttcg 3038341 aaatattatt cagtgtcagc attgactgta acctgctttc cttccttgac cgcgggatca 3038401 ggatagatca cataatcttc cggcgtcagg ccgctcttaa tttccaccat gtcattttca 3038461 tcagtctctc cgatttcaac aggctgctta accgctttgt gattctcatc agctttccat 3038521 acgtacggtt cgccgtcatc ctgaatgacc atgtcggacg gcagcttgat cgtgtccgca 3038581 tcagcattat cactcatcac ttcgatgttg acatgatagc cgacttcaag acctttatgg 3038641 ctgtctaata aaatggtgaa aggatagtta gaggactggg gattcatttc ttcatcagca 3038701 aagctttctg attcttcacc ctcgcctgct cccgctggaa gcttgccgat cgaggtgacc 3038761 tttcctttcc actcgccctc accgcctgtt ttcagcgtga ccctgacttt gctgcctttt 3038821 ttgatcgtgt ccattaacag ctcattgatt tggcttttga ccagatattt gcctgtcgaa 3038881 acaatctgga tatacgggcc tgctgcctgg tcgcctgttg caccgtcagc gatatcctga 3038941 ttgacgcttt gaacgattcc gtcatgcttg cttgtaatga cattggaacc tttgtttttc 3039001 gtcaggccag ccagttcttt ttgatgctgc ttcagttcaa gctggcttgt tttcaaatcg 3039061 aaattggttt gatcaagttc atcttgaagc tggtttttct cttcttttcc tgcaactttc 3039121 agcttttttt ccgtttccgt tattgatttt tgcaaacggt tgatttgcag atttgtcatt 3039181 tcaatttgca aattggcttg ctccacttca tcagaatgat cctcgccctc atactcaaaa 3039241 agcttatcgc cctttttaac ctgatcgcct tctttgacgt atgttttttt aatgctgcct 3039301 ttttctgaat ctatgtatac tttctgctgt ttctcaggtt caacctttcc agaaaacgtt 3039361 tggcctgatt ctgaatctcc tcccatgtat accgcgaccg attcagcata gggctccgat 3039421 gatacggcaa cttggttcat gtgagtaaaa aagtaaaaac cgccagcgcc gatcccagcc 3039481 aatacaagca caccggcaca tatcgcaccg ccaataagcc attttttctt cttggacaca 3039541 acgatctcct ctttctgtaa actatgtaat attttcgaaa cattctaacc aatattatct 3039601 attaattcaa aaagacttgc aatcctttta ttgaaatgac ggaatcaaat agaaaaattg 3039661 tattttcaaa gccgaataaa aaaaatcccg gcttcaaacc gggatttttt catacagtaa 3039721 ctagctcttt ttcattttta atcaagtcat atgtcaagca tacaggttta tttgtacggg 3039781 gatcagtcac gatttcggca tcaatctgaa atacctgctt caaaatgtct ggtgtcatga 3039841 cctccagagc agttccttcc ttgatgaccg tgcctttttt gagcgcgatc atataatgag 3039901 aaaaacgagc tgcatggtta agatcatgaa tgaccattaa aatcgtccgc ccttgctctt 3039961 tgttgagtct gtcaagcagc tgcagaattt caagctgatg tgcaagatca agatacgttg 3040021 taggttcatc cagcagaagc agttccgtcc cttgcgcaag cgccatggca atccacacac 3040081 gttgacgctg tccgcctgac aatgcctcaa tcggccgttc agcatattca gccatgcctg 3040141 tttcttcaag cgcccatttg ataatccggc ggtcttcgtc atttaatctg ccgaatcctg 3040201 attgatgcgg aaacctgccg tacgacacca attcgtgcac tgttaggccg ctcggcgctt 3040261 caggtgtctg tggaagaatc gccatatctt ttgcaatgtc ctttgtagac attttatgaa 3040321 tcgctttgcc gtttaaatag acggcacctg catgtgaacg cataattctg gacattgttt 3040381 ttaaaatcgt tgatttcccg cagccgttcg ggccaattaa ggtggtaatt ttccctttag 3040441 gaatcgatat atttaaatcc tctacaatca ccctgtcgcc ataaccgatt ccaagctgtt 3040501 ccgttgataa tgaattcata ttcggccccc tcctctaatt cgctttcatc aataaataaa 3040561 taaagtaagg cgcacctagc acggaaatga caagtccgac cggaatttct gatggtgcca 3040621 atacatttct cgccagcgta tcagcaagca aaaacaggaa tgagccgatg aaggcggaga 3040681 ccggtatcag cgtctggtga cgtggaccgg tcagccttct agccacatgc ggcgcgatca 3040741 atccgagaaa cgcaatgccc cccgcagctg ccacgcatga agcggcaaga gtgaccgctg 3040801 ccagaagaag aatccgtctt tccttttcaa cagcggtgcc cagcccggtc gccaattggt 3040861 ctccgagctg cataatgttc aaatagcgtg ccttatataa agtaaacaga agcaagatca 3040921 caatccaagg gagaatcgcc cagatcatat tccagttcgc cccccatatt gagccggata 3040981 tccaaaccgc ggcttgcata aaatcatgag ggtccatctt gagctgaaaa atcagcaaca 3041041 gggcgttgaa tccggcattc acccctatgc cgactaaaat cagccgaatc ggtgtcacgc 3041101 cttttttcca tgccagaata taaatgagaa acgcagcgag gattgctcct gccaaagcac 3041161 tgaacggcag cataaatgtt ccgaaaaagc taagatctga agctgaccct tgaaaaaagt 3041221 atataaaaag cactacagca agtgaaccgc cggcgttaat tccgagaata ccaggctcgg 3041281 caagttcatt ttgagacacg ctttgcaaaa tggctccagc tacggagatc cctgctccaa 3041341 caagcaaaga aaggatgatc cggggcagcc tgaactcaaa taagacaagt tcatcacgcg 3041401 ccgttccttg gccgaaaaag acctgaagcg ttttaagcgg tgcaattttg ataacgccca 3041461 aattgagact gataaaaaag accaccacga taagcaaaaa ggtcacagcc attacaatga 3041521 gcggtttgtt tgtttttgtt ttcattacag ccctctcctt tcacgacgtg ccaaataaaa 3041581 gaaaaaggga acgccgataa gagaagtcag cgcgccgaca ggcgtttcaa agggcgcatt 3041641 tacgagtctg gccgctatgt cagcaaaaac aagcaaaaca gcaccgagca ccgccgagca 3041701 aggaatgatc caccgataat ccacaccgac caaaaaacgg gtaatatgcg gaatgatcag 3041761 cccgataaat gcaatggtgc cggcaatgga aaccgcagct ccggtcagaa ttactacaat 3041821 aagcatgcca accagtttca ccgctgatgt atattgtcca agcccttttg ccagatcgtc 3041881 accgagactt aacactgtaa cagaccgggc gatgaaaaac gcgagcgtta aaccgacagc 3041941 ccctgcaata agcaaaagct ggacccccga ccatttcaca cccgctaccc cgcctgcgta 3042001 ccaaaagctg atatcctgag cgacatcaaa gcggattgca atggcagttg aaatgccggt 3042061 aaagaaataa gtaactgccg tacccgccag agcaagcttt acaggcgtaa gtccgcccct 3042121 tgaaaacatg cctatgccca ttaccgtcga tgcccccagc cccgctcccg caaaggacca 3042181 tagcacaagc cccattgcag aaagtccggg aaaaaaggca aacgcaatcg aaaccgcaaa 3042241 cgcagagcct gatgtcacac ccataatcga aggctctgcc aaagggtttc tcgtcatccc 3042301 ctgcatgatt gctcccgaca ctgccaacaa tgcgcctaca agcgcggcag ccgccgttct 3042361 cggaagccga agatcatgta taatttggtg agatgtcttt gtcggctgat aatgaaaaat 3042421 ggcctcccat acagtgcgca aatgaatatc cgctgcacct agggatatgg ataaaaatgc 3042481 gccaaggcaa agcaggcata gacctgcgat aaggacgatg accgcgccat atgtccttga 3042541 cgtccattgg atttcttctg atgcagtccg tatattttta tgttgactca actgccgtac 3042601 ttcctttctg ttactgataa tgattatcaa ttgctgtttc agtatatcac ttttttcagc 3042661 tgatttaata gagtgttttg aacaaaaatg aaaatgcatt tgcaaaaata tcgtgtcaac 3042721 cggcacttgc agtggtataa tcacagatga taatgattct ctttttcatc tatcttttag 3042781 aaagaaggta tgagatatga cccatatata caagaaactc ggagccgcgt tttttgccct 3042841 gttattgatt gcagcgctgg cagcctgcgg gaataactca gaaagcaaag gttctgcctc 3042901 tgattcaaaa ggcgcagaaa cctttacata caaggctgaa aacggaaatg taaaaatccc 3042961 gaagcatcct aaacgggtgg ttgtcatggc agacggctat tacggctact tcaaaacact 3043021 cggcatcaac gttgtaggtg cgcctgagaa tgtatttaaa aacccttact acaaaggaaa 3043081 aaccaacggc gtcgaaaaca tcggagacgg cacttcggtt gaaaaggtca ttgatttgaa 3043141 ccctgacctg attatcgtct ggacaacaca gggcgctgat attaaaaagc ttgaaaaaat 3043201 tgcgccgact gtcgcagtaa aatacgataa gctcgacaac atcgaacagc tgaaagaatt 3043261 tgcaaaaatg acgggaactg aagataaagc tgaaaaatgg ctggccaagt gggataaaaa 3043321 agttgcggcc gctaaaacaa aaatcaaaaa agcggtcggt gacaaaacca tttccattat 3043381 gcaaacgaac ggaaaagaca tttacgtatt tggtaaagac tttggaagag gcggaagcat 3043441 catttacaaa gacctcggcc tgcaggctac aaagctgaca aaagaaaaag ccattgacca 3043501 ggggccaggt tatacaagta tttcattaga gaagctccct gacttcgccg gagattacat 3043561 tttcgcgggc ccatggcaat caggcggtga tgatggcggc gtttttgaaa gctccatttg 3043621 gaagaacctg aatgccgtta aaaatggcca tgtatacaag atggatccga tcggattcta 3043681 tttcacagac ccgatttcat tagaaggaca actggagttt attacggaaa gcttgactaa 3043741 ataaacaaaa gagccgcctg cccgcggctc ttttgcttat ttataaggaa cggctcaatt 3043801 tgaatcatat cggatatttt ctttgagcca ttcatattaa gctgcatcct catcacgatc 3043861 agttttttta tgctggagag actgaaaaac gttttttgca tatttaacga acggattcct 3043921 aacaggagaa attgtgattt tataaaaaag acacctgagc aaatcaggtg tcttttcatt 3043981 atgcttgttt ttctttctgg aacttgttac tcacaaatgg ataaacgatt aagccgacaa 3044041 agaataaacc gatgccgagt ataaatgtcg ttaaatctgc tgtgcctgtt acgataacaa 3044101 acacggagta tgcacacgcc agtatcgcga tcaatccgtc tcttacacgg gagcctttca 3044161 gctggtcata cgtttcacct ttgatgacta ccttcaagct gtagattgca gataccagat 3044221 acggaattaa atatgcgagt gtagccgctg tcgttaaaaa tgtaaatgcg tcacttattg 3044281 tccgggaaat aaccgagaaa atgaagacct gtgacatgac gtttgtaata atgagtgcaa 3044341 tgaccggact tcccttttta ttcgtttttg caaaaaatgc cgggaaatct cctgctttag 3044401 cggcttggta tggcacctca gagccaagca aaatccagcc gagcatcgtt ccgaataaac 3044461 aaaggatagc caaaagcgcc ataatcacgc ttcccgcgtt tccaacaatc gcatagagta 3044521 catcaacaaa tggtttttca gagccgacaa gcttatcatg cggcagaaca cccatcgtaa 3044581 ttaaagtcac aataatatat atgctcaagg caatcagcaa gccggtaatt gtcgcacgtt 3044641 tcacatcacg ctgagagcgc gcacggccgg acaggatcac cgcggattca attccgacaa 3044701 acgcccacag tgtagaaatc gcagcgttat gaacctggcc accaattcca atgcttgtgc 3044761 cgttttctcc ttgaaccggg aaataaaaat gaccgaataa tgacgtttga aacacaaaca 3044821 aaccggcaac gataaagaag acaaaaccta atactttaga aagcgttgtg acaaagttta 3044881 atttacttgc gccgttaatg ctggcaacaa gaatcgcgtg cgttccccat aacaagatcg 3044941 tacatacggc aaacgtcagt aattggccga gtgtcacctc ttgcccgccg atcgaaaaca 3045001 tctcacgttt atcaaccaag atcgggaaga acgaagtcaa gtaaccggcg agacttgtga 3045061 tgatcgccac gttactgatc cagctcgcca cccagtagcc ccacaccatt gtgaaaccgg 3045121 cagcgttgcc ttttttcggg tcagaaaaca gcgctcttgc ataactttgc ggtcccgctg 3045181 tcagttcagg cttgcgaatg gacaagtgtc cgaacacaag tgcaatcatc agcacgccgg 3045241 cacctgtcaa aagccaggcg gacgtagctc caaacggact cgcaattgaa gcaagcgagc 3045301 tcggcaagga gaaaattcct gatccaacca tatttccaac gacaaacgcc gttaataacc 3045361 aaaaacccca tttttttgtc tgttccattc cagtacctcc atgattcttt gtacggacca 3045421 gaccccgaga tcatataaac gcaaaaaaag cctgaacaaa agtccatgct taaagaaaca 3045481 cacacccttg atctccggat agccctccgc gaaaaagcac gcggcagtcc tgcacttatt 3045541 cagatacagt cccagcatag agaaggatcg gctttctcca cacttcggcg ctgatgcctt 3045601 ttacacatgt ttaacagccc ctgtcagcct agcatgtgtg actcatcatc cgcgcaacct 3045661 ctacctcact gagaaagagt gaggatttaa ttattcagtt actcccagaa ggttatcaaa 3045721 gaaaggatga tctgtcaaag ggaacagatg gaaaatacgg atagagccaa gccctatccg 3045781 catgtggtta tcgattattt ttcttttttt gcacagcttc ttgaagcgga tcatctttta 3045841 gagctgaacc agcatcttca agagctcctt ggattacgtt tttttctttt tcggaacgtt 3045901 ttcctttatc tttattaaag aaacccattc gtatcacctc ttttaaaaaa taggtacatg 3045961 tttaagatgc ctttttcctg aaaaattatg cgggatattt tttatcgtcc aaagtcctgt 3046021 tgatcaaaca tacattctct tgatatattt gtaattcaga gattttttgc aaaagataaa 3046081 aggagaagcg gcaaatgaca ggaaaaacac acatcatggg aggcatcgct tcttgtacgg 3046141 cagcggctta ttattatgga tttgatccag tgcttatggc tgcgtcaggc gcggttggag 3046201 cattaatacc cgatatctgc cacacacaaa gcaaaatcgg gagaaaattt cctattttat 3046261 cgaaagtggt cagctccgtt tttggccatc gcacctttac acacagcctg ctgtttatgc 3046321 tcatcatgtt ttttatcact tctacataca ttccagataa aaacatatca gccggcctga 3046381 tgatcggaat ggcgagccac ttgattcttg acgcttggac ggtgaacgga atcaaattat 3046441 tattcccttc cacgatccgc gttcggcttc cattatatat gaagacaggc agtttttctg 3046501 agcagctcgt gctagccggc ctgacccttg cttcatgtta ctacttttat atgctgtttc 3046561 atggccgcat gttttaaaca tgagtgctga gacttgtctg aaccggctgt ttttagtagg 3046621 ttttacttaa gaagcatttc atgcagatga tcaagaaaac gtgaggagtc atattgatga 3046681 aaggaacctt ttttcacaat cagcggtttt tatgtttttc gatcttattt atgtggatca 3046741 aaacgtatgt gatatataaa ctcggctttg atttgcaaat cgatactctg ttggaggagc 3046801 taatgctgct ggtcaacccg ctcagcttta ttcttccttt attcgggatc ggcctgtttc 3046861 taaaagaaaa caagcagcgg gcctttttgc tgattgccaa tttggttctg actgttatct 3046921 tgatctctaa tacgattttt tacggctttt atatcgattt tattaccatc ccggttttat 3046981 ttcaggccag caacatgagc gatatgggca gcagtgtaaa agaactgttc catcctctgt 3047041 ttatcgccct gtttgtggat ttggtttttc tgctgttgtt cgccagaaaa accaaacacc 3047101 cacagacaaa agccgctccc cacacgatca aacggtacta tgcagcttcc tgcggaatgc 3047161 ttttatgcac actggcactt gcagaagtac agcagccgaa gcttttggca cattcttttg 3047221 accgggaaat gctagtcaaa agcatcggcc tgtttcagtt ccatatttac gatacaattt 3047281 ctcagactgt taatatcagc gcgaaagctt ttgccgatga agacagtata actgccatta 3047341 aaaactacac agaggctgat tacagcaagc ctgatcaaag caaattcggt cttgcaaagg 3047401 ggcgcaatgt catctttgta acacttgagt cgacccaaag ctttgttctg aatgaaaaag 3047461 taaatggaaa agaaattacc ccatttatga atgatctcat aaaaaaaagc tattcctttg 3047521 atcatttcta tcagcaaaca gaacaaggca aaacatcaga ttcagaattt atcgtcgcta 3047581 actcactgta tccctccctt agcggcgccg tctttttcac gaaaagcgac catcaatttc 3047641 atacgatgta taaatcgctg aagcagcacg attattattc agccgtcttt cacgctaacc 3047701 ataaaacatt ttggaacaga gatgtcatgt acgatacatt tggcattgac cgcttttttg 3047761 atgttgatga ttttcatgtc actcccggga catcgacaag ctggggctta aaagacaaag 3047821 aatttttaga gcagtccgcc aaaaagctga aaagcctacc gcagccgttc tacagcagtt 3047881 ttatcacgtt aacgaatcat tttccgtttg agattgatga aaaggatcag ctgatagatg 3047941 aattcgattc aagcagtgat ctgttaaacc gctatgtgac cacggttcgc tatgaggatg 3048001 aagcattgaa gcattttatc aaaaaactga aggacgaagg cttatacgaa aattcgatga 3048061 tcgtatttat gggagatcat tacggcattt ctgaagccca taacgaggca atggctgagt 3048121 ttttagggaa agacgaaatc acaccgtatg acaacgttca gctccagcgg gtgccgttta 3048181 tcatacatat cccgggaatc accgatcaac agccggaaac catccctgat gccgggggac 3048241 aggtcgacgt caggccgacg ctgatgcatt tgctcggcgt tgagacaaaa ggcgatatcc 3048301 aattcggcaa tgatttgctg tcgggcgacc gcaccccatt cgccgttctg cgaaacggca 3048361 gctttattac gaacgattat gtatacacaa agaacacgtg ctatagccaa aaaacaggtg 3048421 aagtgctgga agatcaggat gcgtgcctcc cttacaagga gaaagcaaac gaagaactgt 3048481 ctctctctga taaaatttta aatggtgacc tgctcaggtt ttccgaatga aaaaatccct 3048541 ctatcaagag ggatttttta cgtttccaat atcaccttgc cagtcagctt cgtttcatag 3048601 ccgtttaaat gagacagatt cgccttgtag tcctcagaat tcaaaatctc cttcacggct 3048661 ttgagcaact gctcattttt tttcaaaaca acgatatcat attgttcgtc gatgagcggg 3048721 ataaaatcaa cactgcccat atgtgccgcg tgctgtgccc cgattcccgc gtcagcctgt 3048781 ccgcttgaaa cttgtgaagc ggcagcgtaa tgatcagtca cgatatcgcc atatcccact 3048841 acatcagccg gattcacacc aagcaagcca agctgttcat caaggagcac ccttgcgcca 3048901 gaaccctttt ccctgttgat gatccggata tcggctcttt tcaagtcttt ccagccttga 3048961 atgtttttcg gattcccttt ttgcacatac agtcctgctt tgcggagaac gacattgatg 3049021 agacaaaacg gttcacctgt caaaatccgt tttacataag gcgcgttata ctggcccgtt 3049081 tctgcatcgt acaaatggag gctgacaatg tcacacttgc cttgatacat atcaatcagg 3049141 ctgtttaagc ttcctttgta tttacggagc ggcgtctcct gaatggcatt ctccaaatgc 3049201 ttgctgagga tatccatcga aatgtcctgt ccgctgatca tgacatttgg tctgccgtcc 3049261 ggctcagcct cctgcacctg tttcggcgct tcttttgcag cgatgggctg agacattctc 3049321 atattcgttt tatattgctt taaatcttct tcatccacac gcatctgcct tccgacacgg 3049381 taagcaggca gcacgccttt tttaatcaag tcataaacgg tcagctttga taccttcagc 3049441 agacctgcaa cttcttctat cgtataggaa gaggtttcat tcatcatcat cactctccta 3049501 ttttattata ccttttcgcc gaatgtaaaa aaacccacat aaaccaaaca taatcagtta 3049561 taattagtta tatctaatga taaggggtgc aatcatgttt aagaagtatt ctattttcat 3049621 cgcagcctta actgcttttc tgcttgtagc aggctgttct tcaaaccagt cttcaacgga 3049681 cagcgagaaa aaagtaacgt taaccatctc agctgccgcc agcgcgcagg atgcacttga 3049741 ggaaatccaa aaaaattatg aaaaagatca tcaacatata accatccaag ataactatgg 3049801 ctcatccggc gccttgcaaa aacagatttc tcaaggagca ggagcagatc tgttcttctc 3049861 agctgctgag gataaattta aaaagctggt ggatgatgga gatatcgcaa aaaaagacag 3049921 cactgaatta gtcggtaatg aaattgtgct ggtcgtaccg aaaaacggag attcacctgt 3049981 gacaagcttc agcaatctgg ctgaatcaga aaaaatcgct cttggcactc cggaatccgt 3050041 accggcagga gcttatggga aagaatcact gacaaagctg tctttatggg acaaagtgaa 3050101 ggataaaatt gtgtatggaa aagacgttcg ccaagttctt tcttatgttg aaaccggcaa 3050161 tgtagacgca ggtgttgttt ataaaacaga tgccctagtc tcgaaaaagg tcaacattgt 3050221 tgacgaggca aaagcagata cacacagccc aattgtctat ccgttaggaa tcgtaaaaga 3050281 tacaaaacac cgtaaggaag cgaaggaatt ttacgaatac ctgcaatctg atgaagcaat 3050341 gaaagtattt gagaaatatg gctttactgc cgagtagcat aagcgcttca gaatttttca 3050401 cacccgttgt gctttccttt caggtggcgg cagttgccgg aattgttgtc attattctcg 3050461 gaacacttgc tggagcatgg atgtcacggg catcattttt cggaaaaacg gcactcgaaa 3050521 catgttttat gcttccgctc gttcttccgc ctactgttgt cggttttatt ctgatcgtca 3050581 ttttcggaaa gcacagcttc atcggacaag ccatcgagtg gattttccag cagcctgtca 3050641 ttttcacctg gtgggccgct gtgatcgcct cggctgttgt agcctttccg cttatgtatc 3050701 aatcagccaa aaccggattt gctgacattg atcccgatat acaaggtgcg gcaatggtag 3050761 acggcgctag cagatggaaa gtgtttatcc atatctccgt cccgcttgcc tatccttcgt 3050821 tactgaccgg aagcatcctt agccttgcgc gggcgctcgg agaatttggc gcaacactca 3050881 tgtttgcagg aaacatcccc ggtgttacgc aaacactgcc gacggcgata tatgtcgcat 3050941 tggattccgg caacaatacc cttgcttggg cgtgggtcgt ctgtattgtt gtcatttcct 3051001 ttttgatgct gtttttcatt caacagaaaa aaacgcacta aaaaaactcc ccataacggg 3051061 gagttttttg attaaaacag aagctcatca ggatttggac cgacacgctc atctttattt 3051121 aatgcgtcaa ttttgtccat gtcttcttga gacaattcga aatcaaaaat atcagcgttt 3051181 tcgatgatac ggtgttcttt aatggatttt ggaatggtta caactccatg ctgcagatcc 3051241 cagcgcaaaa tcacttgagc cacagattta ttgtgttttt cagcaatctg tgtcagtact 3051301 tcgttatcca aaagctgtcc ctgcatgagc ggagaccacg cttccagctg aatgccttgc 3051361 cctttgcagt aatctcttaa ttctttttgc gtcaagcgag ggtgaaattc aacttggttc 3051421 accatcggtt tgatttcagc atctttcaac agctcttcta aatgatgaac ttggaaattg 3051481 ctgacgccga tcgcgcgaat tttgccgtct ttgtacagct tttcaagcgc gcgccatgta 3051541 tctttatatt tatctttgcc aggccaatgg atcaaatata aatctaagta atcaagctgc 3051601 agtctttcta ggcttttttc aaaggcagca agcgttgttt catagccttg atcttcattc 3051661 cacacttttg atgtgatgaa gagctcttct cttgccacac cggattcttt aatcccgatg 3051721 ccaacgcctt cttcattttt gtagatcgct gctgtatcaa tactgcgata gccattttta 3051781 attgccgctt tcactgattc agtcgcttca ttaccatttt ctactttaaa aacgcccaga 3051841 ccgaaccaag gcatttcaac tccgttatgt aactttacag tatcttttaa acttgttggc 3051901 acttgaacct ccaccctttc actgaaatgt aagcgtctat attatctcac attcctctca 3051961 gccgatacca ataatacgct taagaccctc tttttgcttc ttttttcaca gcacaggcaa 3052021 atccaaacac tatttttttc ctattttaac aatattgaga ttacaaatac attgagcagg 3052081 gtatgcgtgt agtgtaacca aatgaaaaca aaggaggaaa caacttgaaa cgtattcgta 3052141 tcccaatgac acttgctctt ggtgccgctt tgacaattgc ccctttgtcc tttgcttccg 3052201 ctgaagaaaa tcctgctccg aagatgtcgc agacaactac tgctggaaca actgccgctg 3052261 atgtaggttt aaacgtcaac ctggatgtac ttggaattgc caaccagatc gctgatgcca 3052321 tcaaatccgc acagaatagg gatggctttg tgaaaaacct catggagtct tccttctacg 3052381 cgtccggcca aaaatataac gtcatggtct ttaatttaag ccaggaatat gaagatcatt 3052441 tgaacggtgt gcaattttac ggctcagccg tttacgacgg cattacgtat ggcatttggg 3052501 tatttgaaga tggaaccttt acaaacaaag gcgatggcgg ctggatcaac tgggccttca 3052561 gaggctggtt cgaccgggat ggcagcactg tcgcatttca tcgcccttaa tataaaaaaa 3052621 gctggcgctc taacgccagc tttttttctg catttattcg ccgccttcaa gcatggcggc 3052681 ttcgacatca ttaatgtatt ggcgaagctc atgggagatg tcccgggaaa tttccctctc 3052741 ttcgaagagc gtttgaattt catttctgat cgcctgcaca gccttcagct tcacttccag 3052801 cttctgattt tcaaaatggg cacttgattt taactcatga tggctgtgct ccagcctgaa 3052861 aattaactgc ttatagaatg taatgacaga taaaaacact tctttatgct catccgtctt 3052921 atgtttttcc agatattcta tcgctgcttt tgccgttttc actcttgttg cccgtatcaa 3052981 tcccgcttca tttaaaatcg acatctccgg ctttttatgt tcaccgaaga aaatccaata 3053041 catcagcctc ttgagccttg tttttgataa cccgacttta aacgggttgg catacaaaat 3053101 ttccaactcg ttaaatcgtt cttgcagcac atttgctgtt tcttccggga tgtctccccg 3053161 ctccagcatt ttcatcagcg cctcttgctc agccttaacc ccctgcgcac ggacttttcg 3053221 ctcgtgcttc ttaatgcgat tagatgatgt atactgctga aaacgaagat ttttcatttt 3053281 ctcattgtat tcagctatca ccgcaagaga ggccgttttg tttgtctcat tcatgtcctc 3053341 tttaatcgtt tgaagggctg ttttgatcaa cttgcgtctc gccgtcagca gcttcttatt 3053401 tcgttcctcg tcctcttctt ctttttcagt cagaattggc agcacaacgg tggcaatgac 3053461 aagcgtgcat aaaatgacgc cggctgctaa aaagagaatc agatttcttt ccggaaacgg 3053521 cgtaccgtcc tccaggaaat acggaatgga aaaagaacct gcaagcgtta ctgctccacg 3053581 cacaccggaa atcgaaatta acagcgtcga acgaagaccc ggtttataga tgttctgatc 3053641 tttattaaag aaccatttgc cgttccagaa gaacagcacc cacaggaatc taaggagcat 3053701 taatgtaaat gtgatgacta ggatatagcc gatcaccttc atgttgctga tggcagtgtc 3053761 gttaaagata acagaaataa catcagggat ttgcgtgccg agaataacga agaccaggcc 3053821 gttcaaaata aataaaataa tgttccacgt acttgaggag acgatttgca gcttgatcat 3053881 cgttgattcc agacgatcct gttcaaccgc atgggtaata ccgccagcta caacagctaa 3053941 aatgcccgaa acgccgattt cttcagctgc caaataaatc acaaacggcg tcagaatttg 3054001 aatcagcata tgcatcgtga catcctgcat gccaaggcgg cgcagaaata ggcgaaaacg 3054061 aataatcaaa aatgaaatga caaccccgca cagcaagcct ccgagagaaa taaagacaaa 3054121 gctgacagcc gcttgtgcta atgaaaatgc accagtcact gccgctgcaa tcgcaaactt 3054181 aaaggccacc agacctgatg catcattcat cagcccctca ccttccagca ggcgaagaat 3054241 cccttttggc attttcactc ttcctgataa tgcgctgaca gcgacgacat cagtcggtga 3054301 aagaatggcc gcaagtccaa aggccgctgc cagcggaata gcaggaatca tccagtgaat 3054361 cgtgtagccg cctacaatca cagtcgcaaa tacaaggccg agtgcaagca ataaaatcgg 3054421 agcccttaaa ttccaaagct ctgcccgcgg tgtcctcttt ccatcattaa atagcagagg 3054481 cgcgataaaa agaacaaaaa acaattcggt gtttaattca aaatgaagtc cctgtggaaa 3054541 tgaggcggca agaatcccaa gagccacttg aatcagcggc accggaataa acggaataaa 3054601 ccggttcacg atattagaaa tcgcaataat cgttaataat acgagcacaa ctaaaaatat 3054661 gtccaaatgc atgacctcct tcgtctgttg tgtgtcggca tgatgagcca aaaaatctgt 3054721 ttgtctaaaa gcccttgagc tagggtggcc ttgcatccgc tatgtggttt cgcaggagtt 3054781 ctctccacac ttgtcttctt ttatagtacc ctttttaggg tattttttct catgatatgc 3054841 tcacagtgaa cttttttgca gaagagcaaa ttatagaaaa aagagacagg aagctactcc 3054901 ctgtctctcg tctttctttc tcaatcatga aaattcgtac cgtcagttgt tgctttaata 3054961 atgcccgcgc gaatgacaaa gtcaccgaaa tgctcgcctt cctcgcgttc tttcgcatag 3055021 cgggaaagaa ggatgcgcag ctcgcttaaa atgtctgctt caccgatgtt ttcacggtac 3055081 attttgctta aacggcttcc gtcaaacgca gcgccaagat acatattata tttgcccggc 3055141 gcctttccga taaatccgat ctcaccgagt gcatgacgtg cacagccgtt cgggcatcct 3055201 gtcatgcgaa tggtgatttc ctgatcacga aggccgtttt cgtcaataat ctcttcaatc 3055261 ttatctaaca gggtcggcaa ataacgttct gcttcagcca ttgccaatcc gcaggtcgga 3055321 agagcgacgc acgccatcga gctgcggcga agcgctgaat agtgcttgcc gtcagttagt 3055381 ccgtactgtt caattaaagc actgatttct tcttttttat cgcttgaaac gttcgcaatc 3055441 attaagttct gattggctgt cagccggaac tcacctgtat gaactttggc gatttcccgc 3055501 aagccagtca tcagcttata atcatcgtaa tccgttatac ggccgccttc gacaaacagc 3055561 gtgaaatgcc atttatcctc gatgccttcc acccagccat agcggtcgcc gttatgatcg 3055621 aaatgatacg gcttcgcttc ttccaggctc cagccgagac ggttttccaa ttcttctttt 3055681 acgttttcta aaccgaggcg gtcaactgtg tatttgaacc gcgcattttt acggacagaa 3055741 cggttgccgt aatcacgctg aatcgtaatc gttttttcag caacgtcata catttgctca 3055801 ggccggcaga aaccgatcac cttggctaat tgcggatatg tcgcagtatc gccatgcgtc 3055861 attcccatac cgccgccgat tgccacgtta aaaccgatca gcttgccatc ctcgacaatc 3055921 gcaatgaatc cgagatcttg tgaaaagacg tcaatatcat tagacggcgg aacggcaata 3055981 ccgattttaa acttccgcgg cagatagagc ggtccgtaca ttggctcgac ttcttcctcc 3056041 ggcgtgccgg caactctttc ctcatcaagc caaatttcat gatatgctct cgtccgcggc 3056101 agcagatcat cacttaattt tttagaccac tcgtatacct ctgagtggat ttcagattga 3056161 taagggtttg atgcacacat gacgttacgg tttacgtctc cgcaggctgc gatcgtatcc 3056221 aaaagtgctg agtggatcgt ctgaatggtt ttcttcatgt tccatttcag aattccgtgc 3056281 atttggaatg tttcacgtgt cgtcaatttt aatgtgccgt tcccgtattt ctgggacagg 3056341 tcatccatga caagccattg ttcaggcgtc gagacgcccc ctggcatacg cacgcgcagc 3056401 atgaactgat atgcgggctc aagcttctgc ttttggcgtt catttcggag gtcgcggtca 3056461 tcctgcaaat aactgccgtg gtgtttcatc aggcggttat catcatccgg aattcccgca 3056521 ctgattcgat cgagcatcac ttctttcagc gtgccgcgca aataatcact ttctttttta 3056581 atgcgttcaa catcacttgg agagccgtcc ggtgctttta gaattttggt caccatgttg 3056641 aaaaactcct ttcaagtcaa atcaatatac atcacgctga tagcgttttt gctgctgcat 3056701 atcggcaaga taagcctccg cctcttcgcg gctcatattg ccttcttttt cgataatttc 3056761 aagcaatgtg ttatggacgt catgcgccat gtgcttttca tctccgcaaa tgtaaacagc 3056821 cgctccttct tgaagccatt caaacaattc tgcgctatgt tcaagcatgc ggtgctgcac 3056881 atatactttt tcttccgtat cacgtgagaa cgccacatcc atttttgtca gcacaccgtc 3056941 tttgagccaa ttctgccact ctgtctggta aaggaaatcc gtgacaaagt gctgatcgcc 3057001 aaagaacatc catgcctttc cttccgctcc cgtctcctca cgctcctgca taaacgaacg 3057061 gaaaggtgcg acgcctgtcc cagggcccac catgataatc ggtgtttcag ggtctttcgg 3057121 aagcttaaag ttttgattgt gctgtacata aaccggcagt gtgtctcccg gctgcagtcg 3057181 ttccgcgcac aaaatcgagc agacgccttt tcgttcacgg ccgtgcgcat cgtagcggac 3057241 tgcgccgatt gttaagtgca cttcatccgg atttgcggat aaactgcttg caatcgaata 3057301 aaggcgggca ggcatttttc gcaaaatcga gacaaactcc tgcgcagata cactaaatgg 3057361 gccatagtca cggacgagat caagcaaatc gcgcccttca atataggctt ttacattctc 3057421 ctcatttccc ggggctaaaa gctctctaag ctcatcgttc cctgtcagct gggctgcctg 3057481 ttcaagaagc ggttttgtga gaacggtaat ctcatagtga gaaatcagcg cttctttcag 3057541 cggtcggaca tcaccttgct tattaagcgt cacaatttct tccgggtccc aattcatttc 3057601 cttaaggagc agctcgacaa gttccggatc gttttccgga tagacgccga ggctgtcacc 3057661 aggctcgtaa gtcaggccag atccttcaag agacagctcc acatggcgtg tttctttatt 3057721 tgatcctctg ccgtttaaat ttaaattttc taacacttca gcccgaaacg ggtttgttct 3057781 ggaatacgaa gactcaccgg tttgtgacgc agccgccggc gcaggcgcgg cgcttccgcc 3057841 cccagcttca tttaatcctt tcaatacacc ctcaagccat tcggctgccg gttcatcata 3057901 gtcaagatcg caatcaacgc gcggagaaat ccgttttccg ccgagttctt ctaagcgttg 3057961 atcaaattct ttccctgtct ggcagaaaaa ttcgtacgaa ctgtcaccaa gcgccaaaac 3058021 ggaaaagcgc aggtcttcaa gcttaggcgc ccgtcttccg tgcagaaatt catgaaacga 3058081 cagcgcgtta tcaggcggct cgccttctcc atgcgtactg acgacgatta aaagattggt 3058141 taccttcttc agctgattcg gcttaaaatc gctcatggat gagacggtca cttgaaaacc 3058201 gctctgttca agctgcttgc cggcattttc tgcaagcccc tgtgcgtttc ccgtctgtga 3058261 accataaaga acggtcactt cttttgaaac ggccggtgcc ggtgcttccg ctgacacagc 3058321 tgccgccggc gtacccgcag cttcttgggc ggaaacagat tgagcggata aatatccgct 3058381 cagccagatt ttctgggatt cggtcaaggt cggcagaagg cggttaagga gctctgcctg 3058441 ctcctgatta aacggactgt tcattacctg aagttgcaac gtatccacct cacaaagtta 3058501 taaactgatc gaaaattgca tctaattgaa ctttaccgga atactaggct taagtaaaat 3058561 atatttacat gatgataact attaagaatc ctaatgataa aacggctatg cttcatgtaa 3058621 atagaaaaaa gagaaggact cccttctctt cattcagcaa tctgatataa gtgaggcggc 3058681 acagcggtta caaacggact ggcttcacct gtataaaata ccgccagcat gtgcatcgca 3058741 cgggtgcacg cagtatataa aagcctgcgg tcgtgctctg tatgatagtg ttcttcagat 3058801 gcatcataga caagcactgc gtcaaattca attcccttcg ctaaatacac cggaatcacg 3058861 caaacaccct tttgaaatgg ttgattttct ttatgaatca ggcgaacatc tgtatattca 3058921 ctcatgtggg cgtgcgcctg tatgcattga tgcgcagtct tgcagatgac ggctattgtt 3058981 tcgtgccctt ttttcttgag ccggccaatt tcttgcgcga gcttttggca aaggctctca 3059041 tgtccttcag ttttgacaac gagcggcatt tccccgcttc tattaaacgg ctcaatatcc 3059101 gctccatctt gaagcatcgc tttggtaaac tcgacaatct gccttgttga tctgtatgtt 3059161 ctctttaaac gaacatactc agcaggctca tcctcaaagc acgcatccat acgctgatcc 3059221 ccgtttatgg tatgcgcgta gatggactga ttgatatcac cgagcactgt catgctggca 3059281 gccggaaaaa tgcttctcat gtaagccatc tgaaacggtg aatagtcctg ggcttcgtca 3059341 ataaatagat gtttgatttt cgtatttttc tttctgccct caatcagatc ctgcatataa 3059401 agaaacggtg ccgcgtcctc atagagcaat ttattatccg taaatgccga acgggtcagc 3059461 tcacctatcg catccatctt ctcatgttga aattttcctc cccagccaga aaacaattgc 3059521 aaataaagtt gtgtaacatc aagaaatgca aggagcctga ctgcctgttt gagcggtttg 3059581 aaagcttttt tcacaatgat ggcggcaagc agctgctgct ctctttgata atcgttaaac 3059641 gtactctcgc tgaaccgttt cctttcctgc agttttttgt acacgtccaa gtagtcctct 3059701 ttgtcaagca gctcagcttc atgaacaacc caatcctttc gccgttcctt tttctcaagc 3059761 ttgttaagct cactcagcag ccacttcgcg gtttgctcca tccgattcgg aatggagtga 3059821 ttttgatcca atgagtaaaa ataggattga atttgctcct ttgtgatcag cttttgtccg 3059881 cggaatataa tatttttaaa aatcatccct tcagaggaaa gccgtgtgac gtattcatta 3059941 atgaattgct gaaaggataa acccgccttc catgtgattc ctgcaagcct tgttggaaaa 3060001 tcgcctccct ttgtttcggt caggcaatat tcgagctgat caaaggggct ttcacatttg 3060061 aacttgcggc caagacgatg ctcgatatat tcctgaaacg tcgcctgctc catattctct 3060121 tctcctaact ccggcaaaac agaggagaca tagctgttaa ataagaagtt gggtgaaaac 3060181 aaaacgattt gtccggcatc aatgacaccg cggtgcctgt ataacaaata agcgacacgc 3060241 tgaagcgcag ccgatgtttt cccgctgcca gccgctccct gcacgatcag gatcttgctt 3060301 ttttcattac ggataatctg attttgttct ttctgaatcg tagacacgat gtttttcatt 3060361 tgggtatcag agtgatggct taatacctct tgcagcattt catcgccaat cgtcatatcg 3060421 gtattaaaca tcgccttgag agtgccgttt ttgatcataa actggcgttt cagcaccatt 3060481 tccccttcta tcgtttcacc gggcacctcg tactccgctt ttcctgggga ataattgtag 3060541 tacaaacttg atatcggcgc cctccagtca tagatcagaa agtgttcctc cttctcatcc 3060601 aaacaggaag ctaaaccgat ataaattcgc tctgcctgct cctcgccgtt ttcaataaaa 3060661 tcaatccggc cgaaataagg cgattttttc aattgatgaa ttcgtttgag ctgctgatcc 3060721 atgcgccgat gattgtgttc ccgatcagac agcagctctg cctgctgctt aatgctagcc 3060781 atcgtttcaa tcgcttcatg ggcatcatca aaattaacct taacatcctc ccaaaagctt 3060841 tttcttaatc cgatgatatc atgcttcaac ccgcccgcag acgtttccag aaaccgctct 3060901 tttttttcga gctccttcag cacctcatct attctcgact gctcttcctt ccattcctta 3060961 tcctgctgat tcatgaacgg cacctccaga aaatagttga caaacataga tgaaatactg 3061021 taaaatataa ttggatacat atattaaata tatgatgcaa actggcaaat acaatttata 3061081 atagcacatt cacccaatac caatcaaggt ttgggttatt tatattatgc agaaaaaaac 3061141 cgatttcact tcgaaatcgg tttttttgct attaattatc taagcgaaaa gaacggtttg 3061201 gcagcttcca attaaacata taggaacaaa cccggcaaac aacgagcacg aaaaacagaa 3061261 cgtataagcc gaacgagttc cccagccagc ccaagccgac gattaaaccg ccgagcgccg 3061321 cccataccgc atagatttcc gctttcagca caagcggttt gcgcccggca agaaggtcgc 3061381 ggatgatccc gcccccgctt cccgtcagca ccgcagccac gatcacggca ctaagcggat 3061441 ggcccatttt gacggcatac agtgcgcctt ggatagcaaa ggcagcgagg ccgatcgcat 3061501 ctgataaatt gccccactta ttccaatgct tcagcagcag cttcggaaac agaaacacaa 3061561 ttgtaataga taaaagcgcg atttgaaagt acgctccctg ctcccatagc gctgacaccg 3061621 gaacaccgat cagcaaattg cggatcgctc ctcctccaaa agctgtgaca atccctaata 3061681 tataaactcc taaaatatca tattcctctt ccatcgcaac aattgcgccg ctgactgcaa 3061741 acgcaatgat gccaatcaca ctaagcagct cccaagccat tctgatgact cccttttatg 3061801 tttgttaaat tttctgacga cctctagatt ttataatcgc tccagcgtaa aatcaataac 3061861 attttcatga gaaaaaaaga taaatttaga gggaatacgg ctattgctga tggacatgag 3061921 tttgcgaaat taaaaaagcg cccggcatac gcgggcgctt tttttgttat tcagattttt 3061981 cgcctttcag caggcacata aaaatgataa tcaggataaa agcaatcagg gccaggaatg 3062041 gaatcgtaat aaaaccaaac cagttaatat attggcccga gcacggcacg ccgctgacac 3062101 atggcttaat gccgctaaag ccgggcactt tttgctctaa gtaatgcatg atcgaaatga 3062161 atgccccaat aatcgccatc gggagcacat attttttcac tcgtgtgtcc ccttgaaagg 3062221 tggcgatgcc taaaatcagg acgagcggat acatgaggat acgctggtac cagcacagtt 3062281 cacatggaat aaactttctg atttcactga aatacaggct gcccagcata gcgataagag 3062341 ccacaaccca ggaagcatat aaaaatacga ttctattttt catattgtta cttccctttc 3062401 agctcttttt ctattgtctc tttgatttca tcataatccg caaaattttt gatcacttta 3062461 tcattgacgt aaatcgtcgg tgttgcctgt atgttcattt tttgattaag gtcagaatcc 3062521 ttttccactt gagaagcgaa tgtttcctta tcaagatttt ccttgagcgt ctcaggtttt 3062581 atctttgtgg tgctttttgc aagatcacca aggaggcctg gggttaccca ttcctgttcc 3062641 gtatccggct gtttttcgaa cagcttttca tggaaatccc agaaagagtc agggtcttcc 3062701 ttccatactt cttcagatgc aagagccgct aaccttgaac cttttccatg gaacatgacg 3062761 ttcacgaaag aaaatttcac atcgccctta tcaataaagt ctttttgtat ttttggaaag 3062821 atgtcactgt taaacacctt gcaagacgga catttgtaat ctccgaattc tactacagtt 3062881 accggtgcat cgtccttgcc aagcacaggc tgccctttga tagacggctg tccggacacc 3062941 gcatcattgc cttgttccgt tttgttatta atgatgacaa tggctgctag caatacaaca 3063001 accacaaccg taaggatgac cgcgaatttc gcagaagact gctgtttctt tttcactccg 3063061 acacctcatc gttttaaaat taaaaaagaa gcggatcgca attgacccac ttctttattt 3063121 taacaagaca agcgctgata agaaaacccc gaaaaaatga attctctccg acaatttatt 3063181 tgtttttgag acgcatgacg cgcatggcgt tcgccacagc aagcagtgta acgccgacat 3063241 ctgagaaaac cgcttcccac atggtcgcaa ttccaaatgc accaagaatg agaaagatcg 3063301 ctttcacacc taaagcaaag ccgatgtttt gccacacgat tcgccgtgtc cgtttcgcaa 3063361 tccgaatcgc ttctgctatt tttgacggct gatctgtcat cagcacgatg tctgcggctt 3063421 ctaccgcggc gtctgagcca aggcctccca tcgcaacccc tatatctgcg cgtgcaagca 3063481 ccggcgtatc attgatgccg tcaccgacaa aaatgagttt ttcactaggc aaaagcttag 3063541 cttctaatgc ttcgacctgc gcgactttat cttgcggcag cagctctgca tatacctcac 3063601 caatcccaag ctgttttccg acggcttctc ccgtttgttt cgaatcaccc gtcagcatag 3063661 ctgtctgttt gatcccaagc gacttcagat cagcaaccgc ctgtgctgcg tcttccttta 3063721 tctcatccgc tatgatgatt gctccggcat agcgttgatc tacagcaacg tgtacgattg 3063781 ttccagcatt ttcatccggg acatcctcaa tttgttctct ttccatgagc tttttattcc 3063841 cagcaaggat ctcagttcca tttacctttg caaaaatgcc gtgaccggag atttcttcgt 3063901 atgactcaat ctcatcggag gaaagcattt tcccgtaagc tttacgcaca gattcagcaa 3063961 tcggatgctg tgaatgaagc tcagcgtatg ccgccgcttc aagtaatcta tcctttgtaa 3064021 aaccttccgc gggtttgatt tctgtcactt caaagctgcc ttttgttagt gttcccgttt 3064081 tatcaaacac cgcgtatttg acttgattca aagcttctaa ataattgctt ccctttacaa 3064141 gcactccggc ctttgaggcc gctccgattc caccgaagaa accgagcgga atagagacaa 3064201 caagcgcaca aggacaagaa atcactaaaa agataagcgc gcggtacacc caatcggaaa 3064261 gcgcggcgcc agaaagaaca agcggcggaa caaaggccag caataccgca atgatcacca 3064321 cagcaggtgt ataatacttg gcaaacttcg tgataaagtt ttctgtccgg gctttacggc 3064381 tgctcgcatt ctgaaccaag tctaatattt ttgatactgc tgattcctga tagccctttg 3064441 tgacttcaat atgcagaacg ccgttttgat tgataaagcc tgacattaca tcttgtcctt 3064501 ccgcagcttt tctcggaacg gactcacctg ttaaagcaga tgtatcaacc atcgctgacc 3064561 cttgcacgac cttaccgtcc aggggtatgc tttctcccgg attaaccaca atgatgtctc 3064621 ctgtctgaac gtcctccgac gaaacctgtt cgatgccgtt ctttgttttg agattggcgt 3064681 aatcaggccg tatgtccatt aacgcactaa ttgattttct ggaacggctg accgcggctc 3064741 cttgaaaaag ctcaccgatt tgataaaaca gcataacggc gaccccctca gggtattgct 3064801 gaatcagaaa agcgccgatt gtggcaagag ccattaagaa atgctcatca aacacctgac 3064861 cgcggatgat gtttttgact gcgcggatta taatgtcacc gccgataatc aaataagcac 3064921 cgaggaaaag gaaaaattca atggttcccg actgaaccaa atatgccgct gcgccgagaa 3064981 tgacagccgc cgccattctg atcagcatat tgaccattcg attacgatag ccatcatcag 3065041 ctgatttctt tatatgcttt tggcgaaccg ttacatgcgg atcaattgat ttcacttttt 3065101 tctctacttt attcgtgacc cattgctctt ctttcccatc ggctgagaca gttaaggtgc 3065161 ttgccgcaaa atttaccgcg catccgttaa tgccttttat gcctttgact ccattttcga 3065221 tttttcgggc acaattgctg caatccaaac cgtccagaac atattcctgt ttcactagtc 3065281 tcaccttacc ttccgattta gggttccctc ttcaaagcgt atcaatgagt attgtattta 3065341 ttttatatat atgagcatat actcatatat aagttacacc tattatatgt tgttttccaa 3065401 gaaagtgtca atgaaaaaca aaaaccggca tatagccggt ttttcatttt actttttgca 3065461 gacgaagagc attcagaaca acggaaacgg agctgaatgc cattgctgct cctgctatcc 3065521 acggtgctaa aaatccaagt gctgcgattg ggatgccgag gctgttatag ccaagcgccc 3065581 agaataagtt ttgtttaatg tttttcattg tcaatctgct catgcggatt gcgtcggcaa 3065641 tgctgttcag atcgccgcga ataagtgtaa tgtctgctgt ttccatggca atgtccgtgc 3065701 cagttccaat cgccatgccg atgtcagctg tggcaagcgc cggcgcatcg ttaattccgt 3065761 cgcctaccat tgctgtctgg cggccttctt tttgcaagcg ggcgatttcc gccgcctttt 3065821 gttcaggaag aacttccgca atgatattcg caattcccgc ttccttcgcg atggcttctg 3065881 cggttctgcg attgtctcct gtcatcatga tgacatcaag acccaactct ttcagacggg 3065941 caacagcctt ccgcgacgta tccttaatcg tatctgcaac tgctactagc cccgctgctt 3066001 ctccatcaat ggatacaagc ataactgttt tcccttcggc ctctagctct tccatttggg 3066061 cgagaagagc cccatgctca acctgttcgc tctccattaa ttttcttgtg ccgacgagaa 3066121 tgctttttcc tccggcttca gccaaaatgc ctgcgccgac ttttgcttca aagcgggtaa 3066181 gtttcggtat ctcaagccct ttatctttca cgccagcaat aatcgcttcg ccaagcggat 3066241 gctctgatcc cgtttccgct gccgctgcaa attgaagcaa atctttttct tcaaaacggc 3066301 cgaatggaat ggcatccgtc agacgcggct tcccgtttgt cacggttccg gttttatcaa 3066361 gaacaattgt atcgagacga tgtgtttttt ctaaatgctc gccgccttta aataaaatcc 3066421 cgaattcagc agcgcgtcca gatccagcca ttatgctcgt cggagtggca agaccgaggg 3066481 cgcaaggaca ggcaatgaca agaaccgcaa tgaacttgct gatcgcttcg gcaaaatcgc 3066541 caggagccgc ccaaagatac caaatgagaa aagtgagaac cgcaatcccc aatacaatgg 3066601 gtacaaaaat gcctgaaatc tggtcagcga gacgctggat cggcgctttt gacccttgtg 3066661 cttcctcaac aattttgatg atatgagaaa gcgcagtatc ctttccgacg ttgacagctt 3066721 taattttcag aaagccgttt gcgttaacgg ttgaacctgt cacgctgtca ccaggatttt 3066781 tgtcaacagg aagactttct cctgtaatca tcgattcgtc aaccgctgaa cggccttcaa 3066841 ccacttctcc gtcgacagga attcgttcgc caggtttgac gtaaacaatg tcattaacaa 3066901 gcacttcgtc gatcgggatg atttgctcct gtccgtctct tacaacagta gctgttttcg 3066961 cttgaagctt catcagcttt ttaatcgcat ccgaggaacg gccttttgct tttgtttcaa 3067021 acaacttgcc taataaaatc agcgtcagca aaatcgcgct tgtttcataa taaaggccgt 3067081 ctgtatgccc gtgagagcca atgctttgaa aagttagata aagactataa gcgtaagcag 3067141 ccgtcgtacc gagggcgacc aatacatcca tattggcgct tttatttcta agcgccttat 3067201 acgcacccac ataaaacggc cagccgatca gaaactggac tggtgtcgcc agcgcaaact 3067261 gcatccacgg attgagaaat atatccggta cccaaatgaa tgatgtaaat gtaaaatggc 3067321 tcaccatcgc ccaaagcaat ggaaatgaca ggacagctga aaaaatcagt ctcgccgttt 3067381 gcttccgttc ttctttcttt ttagcagcag cctcactgtc ctgttcaccc ttcaacttta 3067441 gcttatatcc aagcttatct accgcttctt tcaaatcgct gacagacgct tcttttggat 3067501 tgtattcgac cgtaactgtt tctaaagcga agtttactgg tgcatttgcg acgccttcta 3067561 ttttgttaag ccgtttttca atccgattgg cgcaagccgc acaggtcatg ccctcaatat 3067621 cgaattcagc tttttctgta acgacgtgat agcccagctt ctctattttt tcctgaatcg 3067681 ctgcagtccc tgtttcagca ggatcgtaga ttacatttga tgtttccgtt gccagattaa 3067741 catttgcatc cgtgacaccg ggcatccgct tcaggccttt ttcaattctg gcagcacatg 3067801 ccgcacaggt cataccagag acctgcatcg cgatttcctt ttgttcactc aacatactca 3067861 ctcctttata tacacctggg gggtatataa aaatgaaaga aatatcgcgc ctccctaaag 3067921 gcgcgatacc ttgaatcact tggctacgtc atagccctga tcttctatcg catccgcaat 3067981 atctttgact gatactttgt cagcatcaaa cgaaacatcg actttacccg cttccagatt 3068041 gacatgaacg gcactgacgc cgtccagttc tcctacgctt gtttctactg ctttgacgca 3068101 gtgctgacaa gacattcctt caacttgcaa tgttttttgt tccatatcaa ttcctcctgt 3068161 ttattctttc tattttcatc ctaccatacc cccgtagggt attacaataa aaaacgcttt 3068221 atgattttgt gaacttttta aatacgtcca aaagctcaga aatggcctgt tccccgtctc 3068281 cgcttttgat ggcatctgct acacaatgat gggcatgatc ctcaagcaaa tgaagcgcca 3068341 catttttcat tgccgcctga acagctgaaa tttgcacaag aatatctaca caatatctgt 3068401 cgttttccac catgttttga atgcctctga cctggccctc aatccgctta agccggtttg 3068461 taatctgatc cttttctttc gagcttttat ggtttaatgt tttatgttcg ttatgctttt 3068521 ccatgcgtac acctctgttt aatgatatta attcccatta tactgattgt ccaaacggtt 3068581 gtctaagcat gccgacgcaa aaaatgaatc agttaggttt taccatttga tcaggagggt 3068641 atatacttct gttgataacg cttttaaagg ggagaagaaa agtggatacg atcaaggttg 3068701 gaatattagg atacggattg tccggttctg tttttcacgg gccgctgctg gatgttctgg 3068761 atgaatatca aatcagcaaa atcatgacat cacggacaga agaagtgaaa cgggattttc 3068821 cagatgctga ggttgtacat gagcttgaag aaatcacaaa tgaccctgcc attgagcttg 3068881 tcattgtcac caccccgagc ggccttcatt acgagcatac tatggcatgc atacaggccg 3068941 gaaaacatgt tgtgatggaa aaaccaatga cagcaacggc cgaagagggg gaaacattaa 3069001 aaagggctgc cgatgaaaaa ggcgtattat taagcgtata tcataaccga cgctgggata 3069061 acgatttttt aacgattaaa aagctgatct ctgagggatc ccttgaagat atcaatacat 3069121 atcaagtttc ctataaccgc tacagacctg aagttcaagc gcggtggcgg gaaaaagaag 3069181 gcactgccac tggtacgctg tatgatctcg gctcccacat catagaccaa accctgcatt 3069241 tgtttgggat gcctaaagcc gtgactgcaa acgtgatggc ccagcgggaa aatgccgaaa 3069301 cggttgacta ttttcattta accctggatt atggcaagct tcaagccatt ctatacggag 3069361 gatcaatcgt tccggcaaac ggacctcgtt atcaaatcca tggaaaagat tctagcttta 3069421 tcaaatatgg aattgacgga caggaagacg cactcagagc gggaagaaaa ccagaggatg 3069481 acagctgggg tgcggatgtt ccggagtttt acggaaagct tacaaccatt cgtggctccg 3069541 acaaaaaaac agaaacgatt ccatcagtaa atggctccta ccttacttat taccgtaaaa 3069601 tagcggaaag catacgagaa ggtgctgcgc tgccagtcac tgctgaggaa ggtattaatg 3069661 tcatccgcat cattgaagcc gcgatggaaa gcagtaaaga gaaacgaacc attatgctgg 3069721 agcactaaaa caaaagcctc cccaaataag gggaggcttt ttcattagaa tgtttttcct 3069781 gcttctttcg cacgcgcaat cgcgtcttct ttgatttgct gtgctttatc aggctccgca 3069841 ttatgtccct ctacgaaaat gccatcgaat gatggtacgc cgaagaagtt catcatgatg 3069901 ccgatgtagc ggtgccccat ttccatctca gccgcagggc cttctgaata gtagccgccg 3069961 cgcgcttgga tatgaattgc ttttttatca gttaacaagc cgacaggacc ttgttctgtg 3070021 tatttgaatg attttcctgc aacagcaaca gaatcgagat acgctttcat cactggcggg 3070081 aatgagaagt tccataaagg agtaacaaat acgtacttat cagctgatgc aaattgatcg 3070141 ctaagctctc ccaaacggcc tactttcgct ttttcgcttt cagaaagctc ttcaaagcct 3070201 gtacctgact gaagctttcc ccatccgcta aatacatctg cgtcaatgtg cggaatgttt 3070261 tctttgtaca aatcgatatg tacaacttca tcatttggat tcgcttcttt gtaagattcg 3070321 ataaatgctt tacctgttgc catactgtac gaagttgctt cgtcatgtgg atgagcagtg 3070381 atatataata cttttgccat ttttaccagc cctttcgttt ttaaaaatca cacatcaatt 3070441 attatcatac agatgcataa tgattattct gtctctctta gactttatta tagagacaaa 3070501 gaaatttact ttcaagtaaa acatctcgaa ttaaagatta tttaactttc ccaaacagct 3070561 tacttttcaa aagctgttct caagccggaa tacagcgcgg acaattcttt actgatccga 3070621 ggataatgag ggacatgcgg cacttgaata tccgcaggca tccttttcat gataaaggat 3070681 tgctcagcct gttcaaaaaa cgcccgcagc tggttgatct cttcatcaga aaacggagca 3070741 gacggacggc ggtgagcttg cgccgagagc aaatagtacc ctaagtgctg agcaccggaa 3070801 atggcaggcc agagcgcatc cgcattcgcg tgaggaaact cgccaagcgc cttgtcatac 3070861 gcatcccgaa gcctgacaag actcaccctt aacttgtgtt cgtcggcaat ttgcccggtt 3070921 aacagtttct ccataaactg cccttccagc cggatgacat tccgcacaag ttctggcagc 3070981 cgcttggttg aaaaccgccg ccacaaaagc attgttccca acagcccgat cacgctgccg 3071041 acagctacat cagtcagcct cgctatcata aaataaccgg cgcccgcccc gccatgcata 3071101 ctttctgtga taacaagcgc atttgcggtt aaaaagggaa cagccagcgc ataattgcgg 3071161 acgatcagca tctcaagaag acattgcagc gctgcaatac aaaacgcaat ataaacaccg 3071221 cccggcttaa aaaacaggat tgcgcctgcc agtataacac cgatcaccgt tccggccgaa 3071281 cgctgaatag ccctgtgaag cgtaaaaaca acagtagtgc caagcatgac cgctgctgcc 3071341 gaaagcggaa tccaatagga gcgtgcaaag ccgaatgcga gggcaaacat atcggcggca 3071401 aacagaacaa ttccgtactt taacgctcta atcaaaactg gagacttcca gtcaaaggca 3071461 tttctcaaaa agtaaaaaga ggatggcagg cggcttggtt ccccgtcaag ctgcttatca 3071521 aaacgtcctg aagcgatata caaaacctca ttgatttctt caaacagctt ccgcctaggc 3071581 tcagattcat tttcattaat ctgaaacgta ttgaaaaccc gtgcattcgc aagcatatct 3071641 ccggtttggc gaagtgcctt ttcaatctgc gcggtctctc tgtccggcgt ttcagctgaa 3071701 aaatgaataa tggcaataaa tatgtcgtca gctttctcaa ggaggcgaaa aaatcgttca 3071761 tcatgccgcg attttttccg tctgttccct ttcccaagaa ccgtttggcg ggctgttcta 3071821 agcatgagca ccgtctgatg ctgtgcgtta tgaaaacctg gcgttccgac ggctgaaaga 3071881 catgcagcca gctgatgata tgttttttgc agcaccgctc cctccggtcc atgtttgttc 3071941 cataaccagc cgattaaagc gatacccatg gcgaaaatgc cgccgagaaa cgtcagtccc 3072001 gctctgaaca gcgcttgtga aggatcggcc ggcagcccgg aactgactaa aaaggcaagg 3072061 acaaaaaaca tcggcgcagg gccttgaatg ccgagcgcgc taaaaataaa catcgccgct 3072121 gcaccgatca gccccaaaac agccgccatc atccaaagca tcccggacaa aagcgtccct 3072181 aaaccaaatg agagggcgat cccaatagaa accaagagca gcttcaaggc gcgctttttg 3072241 tacgattcac cgcccgcata taaataaaca aagcctccga tacttgcaat taatccgtaa 3072301 tccgtgtgac ctgccaatgc accgaccagc acaggaaacc ctgaagcgaa acctgatccg 3072361 atagcctttt tccaaggaaa tggatttgca tgaatgcgaa aggcatcctt cacgataggc 3072421 atgattcttt gattgttcgc agcagttttg ttcatttgac aaaatccttt tcaatgaatg 3072481 tgtagaactt ttccagtttc ttcgctttag tatgcccaaa aacgcggtta gcttctcaat 3072541 tggtgcgcac gataaaaaaa cagagactta taccgtctct gcttcattac atcagtttat 3072601 tataaaagcg gcacctgtca ggactgtttt gtccttctgc cttccttcaa gagcaggtga 3072661 ataaaaaata aaggataaat caatagatac ccattaaaca gccaccacac aagatcaaag 3072721 tcactgctga atgtccagaa tgatagcgcc tgcagacctg aacaacaggt cagcacaaga 3072781 gaaatcagcg ccatcagctt ccagtcagca cgattcaccc gctgtaggta caagctgtac 3072841 aaccctgtga cagaaatcag gatatccagc ggaaaaaaag accagttcca agcgatcata 3072901 aacggatggt catgatgttt aaaagcccag ctttccggta tgagcgaaaa tccggctgac 3072961 agccagtaca agataaaacc gatatcagtc acgagaaaaa acagcttcat atatctcatt 3073021 tgtactgccc gcttttatgt accggctcag acaccgcaac atgctcgatc aggtttaaag 3073081 acacaacacc ggcaataatc aatccaattg aaatgacttt catgacactc acatgttctt 3073141 gaaaaaacaa aaaaccaacg actgtaatca agacaattcc catccctgac catacagcat 3073201 aagcaactga tacatcaatg gatttaagcg taagcgtcag aaagaaaaga ctccctccat 3073261 aaaagaaaat caacagcaaa ctgggaataa gctttgtaaa accagacgat agcttcatgc 3073321 tgacagttcc cgcaacctca aacaaaatcg ccaagcatag aaacacccaa ttcatgtggc 3073381 atcagcctcc tcatcagctg ttataccgtt aaacaaaaca tctacaattg attcaagtac 3073441 ctctcctgtc gtgaactgat gtttcagcgg atattcaggg tcatacactt gattgatgct 3073501 ccctatatac atgtgaacaa acaggtccgg attgatgttt ctgattctct tttgctgttt 3073561 gcactcattt aataatgcta ggacaatcgc ccattcttcc ttaataaacg cgtctaatgt 3073621 aagccacgca tcgtaatggt atttctttag ttcatttaat aatcccatgt tcagcagttc 3073681 catcccctgc ggaaggctga tcagcatttg tttcaccttt tcgagcacat ttaaactttc 3073741 attttcatag atgtctcttt ctatttgctt catttcagct ataaattgtt cgacaaccgc 3073801 ctcaacaagc tgatctttag atgaataata tgcatagagc gtccgcttgc tcgttcccag 3073861 cgctgccgcc aaatcattca tcgtaaatga aaatcctttc tgcttgatca gccggaaggt 3073921 ttccgccaga attcttttat ccatattaat cccccgcttt cggtaccaag aaaactattt 3073981 cggtaccaat attatacggc agaaatttat ggaaatcaac aatatataaa aaaacctctc 3074041 ctattgggag aggtttaaaa gacactgcgg accaaaccgc cgtccgcccg aagtgccgcg 3074101 ccattgatcg cagaggaaag cggactgctt aaaaatgtaa cgaagtgggc gatttcttcc 3074161 ggacggatca gtctttgaat aatagatgtc ggccggtttt ctttcataaa acgtgcctca 3074221 gcttcttgaa cagtcaggtt ttcaccagga tacagcgagt tcagcatggt ttccacaccc 3074281 tctgttaagg tagagcccgg catgacggtg ttgactgtga cattcgtgcc ggttgccagc 3074341 tccgccaaac tgcgggaaat ggacagctgc atcgtttttg tcgcactgta atgggccatt 3074401 tcctgtgacg gcataatcgc cgcttcactg gcaatgaaaa tcacacgccc ttcttttttc 3074461 tctatcatgt tatgcaaata cctgcgtgtc agccttacac cgctcataat attcacttca 3074521 aaaaaacgaa accattcatc gtcgggaata tcaaagtact ccgccggttc aaaaatccct 3074581 aaattgttga ccaaaatatc aacctctgga tatgcctgaa acagctcatt gcagccttct 3074641 tctgttccca aatcaaatgc agccggataa agaaccgctt cagcatgttg tgttttcagt 3074701 tcatctatcg tttgattcac tttctcttcc cggcgtccgt taatgatcac tgccgcacct 3074761 tcttcagcta acgaagaggc aatagctttt ccgatccctg atgtcgaacc ggtcaccagt 3074821 gcggtttttc cttgtaaatt cagcttcatt attcatccct ccgtttttga ttcctcttat 3074881 ttattgacag aaatctgatt ggtgaaacat ctgctctgca atcagtatga aacagctggg 3074941 attgaaatgg aagtacgcac tttttggtgc ctgtggtttg gagaaaaaat aaagcagaac 3075001 ctcttaagag gttctgcttt attgtcagta tgtatggaga cggtgggagt cgaacccacg 3075061 tccagaaaca tcgattactt aagcgtctac gagcgtagcc tgcatattta tggtttcact 3075121 catcttcttg cctgcgggcg ggccttccga gagctagtct gttcatctct tcttacgttc 3075181 tcagacggga acgcaagcgt agcctacttg gatgtgctct tcacagacac ataggcaatg 3075241 tcaggaagag ctcgctgcgc ttattaggca gctaatgcta cgttttggtt aaaactgtta 3075301 gttttgccag ttatatttaa gtgcgtgttt acgagatcgc ctctcggctc gcagctcaag 3075361 ctcgatccat ccctgtcgaa tccgtaacgt ccccttggta taagggaaat acgggagaaa 3075421 atatcaagct ctcactcaaa ctggctatag tcttattata acatgatcac ggctcttttc 3075481 aattgtcaaa tccttcaaat gaatggcgtc gtgatctgat cgtgaacaca gtatagcaca 3075541 ggcctgattt tcgaatcaag cactatgcct ttagaagcct ttttgactgt ctctgaacgc 3075601 tctttcgatt tcccgcttcg cgtccttgcg cttcagatct tcccgtttgt catagttctt 3075661 cttccctttt ccaaggccga gaagcacttt ggcaaagccg ttttttaaat acagcttcag 3075721 cggaacgaga gaatagcctt tttcctttgt taacccgatc agcttattaa tctccttgcg 3075781 gtgcattaac agctttcttg tccggagcgg atcgtggtta tagcggtttc cctgctcata 3075841 tgggctgacg tgcatattgt ggagaaacac ttctccccgt tcgattttgg cgaaggaatc 3075901 cttaaggttt acgcggccgg cgcgaatcga tttgatttcg gttccttgca gaacgatgcc 3075961 tgtttcatag gtttcttcta taaaataatc gtggttggct ttcttatttt gagataatac 3076021 ttttcctgac ccttttggca tgccagaacc tcctctctct aaggaaaaac tgtccacctt 3076081 ttgcgatacg ctctatttta ccaaatgtca cgtaccgcta caatgaaaag ctgtttccga 3076141 aagaaagcaa atagagcgct gcggccctat ttgctggttg agctgctatt tcttcttttt 3076201 ccgtttctgt ttcggagcat tctggaagcc gcgttttttc tttttcttct tcggcttagt 3076261 gaaccactcc cctttttcct cagacggagc tggagaaaca ggtgtattgg tgctttgaac 3076321 acgttttctg gcaggctttc cgcgttttct gctccggctg ctgtccaatt ctctcggacg 3076381 ccgcggagtg cctttcatgc cgacaatttc aaagtcgata ttgcgctcat ctttattgac 3076441 atcgacaacc ttgactgtga tttcatcccc gatgcggaag acgttgcctg tccgctcgcc 3076501 aatcattgcg aaatgctgtt cgtcaaagcg gtagtagtca tctgtcataa agctgacatg 3076561 gacgagtcct tcaattgtat tcggcagctc gacgaacatt ccgaagtttg tcacagagct 3076621 gatcatgccg tcaaactctt caccgatttt atcaagcatg tattccgctt ttttcagatc 3076681 atccgtctca cgctcggcgt caactgcacg gcgctccata gatgatgtat gttcggcgat 3076741 atccggcagg cgttcagccc acttttcctg tgtcgcttca tcgaccttgc cgttgatcaa 3076801 atacgttcgg atcagacggt gaacgattaa gtccgggtaa cggcggatcg gtgatgtgaa 3076861 atgcgtatag aattccgttg acagaccgaa gtgccccaag ctttgcgggt cgtatttcgc 3076921 ctgtttcatc gaacggagca taacagtaga tataaccgtt tcctctggtc tgtcacgcac 3076981 agcgtccaga atgctttgca gcgcgcgcgg atgaatattc cccgccgttc ctttcaccac 3077041 atagccaaat gtcgtcacaa attctaaaaa cttttgcagc ttttcagcat tcggctcttc 3077101 gtgaatccgg tatataaacg ggacattcat ccaatggaaa tgctccgcaa ctgtttcgtt 3077161 tgctacaagc ataaattctt caatcagctt ctcggcgaca gagcgttctc tgatcacaac 3077221 gtctttaacc gctccttcgt catcaacaag cacctttgct tctttgaaat caaagtcaac 3077281 ggcgccgcgg tccatccgct tatcgcgcag aatttgagcc agacgctcca tgtctttgaa 3077341 catcggaaca agaggctcgt atttttgttt cagctcttca tcatcatcaa caagaatttt 3077401 attcacatct gaatatgtca ttctttccgt tgttttgatg acactttgga agatctcgtg 3077461 ctctgtcacc tgtccctgac tgttaattgt catttcacaa gaaagcgtca ggcggtcaac 3077521 ctttggattt aaggagcaga tgccgtttga caatctgtgc ggaatcatcg ggatgacacg 3077581 gtcaaccaga tacacacttg tccctctttc aagcgcttct ttgtcaatcg gcgagttttc 3077641 ggttacgtaa tggctgacat cagctatgtg aacgccaagc ttgtagcttc catcatcaag 3077701 cttcgtcacg gtaactgcat catccaaatc cttcgcatcc gcaccatcaa tggtgacaat 3077761 cacctggtca cggagatcac ggcggtcttt cagatctttt tcatcaatcg tgtcaggcgt 3077821 acttgatgcc tgttccatcg cgtcagctgg aaattctccc ggcaggccgt gcttatgaat 3077881 gaccgataaa atatcaatgc ccgggtcgtt tttgtggccg agaatggttt caacctcacc 3077941 ctctgcgttc atgcggcctt caggatagct cgtcagcttg acaacaacct tatgcccttc 3078001 cgcagctcca tttttcccat ttttcggaat gaagatgtca ctcgtgattt ttttgtcgtc 3078061 cggaatgaca aagccgaagt ttctcgtttc tgtatacgtg ccgacaaccc gctgaatcgc 3078121 tctttctaaa atccgtatga cggttccttc ctgcctggag ccgcttgatt gtgagttcag 3078181 acgcaccatg acgatatcgc cgttcattgc cgtatttagc tcattaggcg gaataaacac 3078241 atcacttaac gacgtatcct caggcagcaa aaaggcgaat cctttcgcat gggctgaaat 3078301 ctttcctttt attaaattca tcttctccgg aatgccgtag cggtcgcttc tcgtccgtac 3078361 gataagccct ttttcttcca aggcgactaa cgctttgacg agctctttaa actcctcggc 3078421 ttccgtaata tttaacatct cctcaagttc ctgaacggtc agaggtttgt acgcctcttc 3078481 cttcataaac gagagaagct tttccataaa tgcttctttt tccattatcc gacctcctgt 3078541 tgattaccaa tcgagcttct ctaaaaattc atacacatcc tgatggacga ggtcacgttc 3078601 tttgtcgagt gtaatgacat gccctgattc ctcgtaccat ttcagctgtt tatcatcagt 3078661 ttccacttcg ttgtaaataa tattggcgct ttcggtatta atcatgtggt catgacgggc 3078721 ctgcaccaca aatgtcggtg aataaatcat atcgacatta ttccgcacat cagcaattaa 3078781 gtcttgcagc gccttgaggg tattcatcgg cgttttttcg aattctttca tttcctcttc 3078841 aatttgctcc gggcttttcc cctcaaactt tttgtaattg cgagcgtatg aaagaacgcc 3078901 ttgatacatg acctcttcac tcttaatatg catcggtgcg cacattggga caattccctt 3078961 tatgggtaca gtgtaaccca atttcagcga aaaaaccccg ccaagcgaca gtccgcaggc 3079021 agcaatgctc tcataacctt cagattttaa atattcatag ccatccatta cgtttttcca 3079081 ccagtcttcg ggccccgtat gtacaagttc ttcaggcggg acgccatgtc cttcatattg 3079141 aggcgcgtgg cacgtatagc cgcgttcatt caaatatcgt cccagcatcc ttacatccgc 3079201 tgtatttcct gtaaagccat gcagcaaaag caccgctttg tctccgcctt taaatgtaaa 3079261 tggttttggt gtcacaactt tcatgctcat gtctcccttt ctatctgcac gatcatttta 3079321 gttttccaca gtttaatcag aaaaaaacgt tttgaatatc atccagaaac gtgaaaaagg 3079381 cctgacttca catcagacct tatacaaaca ttgccctata ggatataagc aagcgcaatc 3079441 gttaacacga aaaacaagac tgccagcact accgtaatgc ggtgcaaaat taaatcaaga 3079501 cctcttgctt tttgtttccc gaagagctgc tccgctccgc ctgaaatcgc accagataat 3079561 ccggcacttt tactggattg aagcaaaacg acaataataa gtgcaatgct gacgataacc 3079621 aataaggtaa tcaaaactgc gtgcatccca tacacctcca gactcactgg ctacattact 3079681 tctattttac atgaaaaggg ttggcatgtc acgctgtatc agacgccaaa aggccggata 3079741 agacgtttta tcttggttac cctattcata tgaaaaggtc aaaggagaaa agcgatgccg 3079801 cttatcagca tagacagcag gaaacatctt ttttatgaag aatatggaca gggaatccct 3079861 atcattttta tccacccgcc gggcatggga cgaaaggttt tttattatca gcgccttcta 3079921 tccaagcatt tcagggtgat ttttccggat ttaagtggcc acggtgatag tgatcacatc 3079981 gatcagccag cgtctatttc ctattacgca aacgagatcg cgcaattcat ggacgctttg 3080041 cacattgata aagctgtgtt attcgggtat tctgccggag gcttaatcgc gcagcatatc 3080101 ggcttcaccc gcccggacaa agtgtcacac cttattctgt ccggcgccta ccccgctgtt 3080161 cataacgtaa tcggccagaa gctgcacaaa ctgggaatgt atctgcttga aaaaaacccc 3080221 ggtttgctca tgaaaatcct cgctggcagc cacacaaaag acagacagct tcgcagcata 3080281 ttaacagacc atatgaaaaa agcagaccag gcccattggc atcagtatta tctggattcg 3080341 cttggctaca actgcattga acagctgccc cgcctagaaa tgccaatgct gtttatgtat 3080401 ggcggcctgc gggactggac ctttacaaac gcaggctatt accgaagatc gtgcagacat 3080461 gccgaatttt tcagattgga atatcaggga catcaattgc cgacaaaaca atggaaaacg 3080521 tgcaatgagc tggtgacagg gtttgtgctg acacatcatt cataggaata gaaaacgctt 3080581 ggcttccttg cgttttttgt tactttattg acttttgtca acgaaatcat agtaaaaaag 3080641 atcctcaaat ttcaaattaa aatagtgaag cattttacca atcacaagct gccccggcct 3080701 tctttctcca ttcagcacgc ggctcagtgt ggcgggtgag actccgattt ccagcgcaag 3080761 ctgattaagg gaataatcgt tattaaccat atactgcaag acataatcac gtctaatctg 3080821 tatcttttct actggcactt tcctcacctt ccattcctga aaaacttttt tctatacttt 3080881 tacattacgg cttatgttaa cttttgtcaa tacatttcca gtctacctat tccctttagt 3080941 caataaacat actaaaatat gagtaacagt gagggacggg gtgagatata tggaaagctt 3081001 tggcgaacaa ttacgggcat tgcgtgaaga gagaaagtta acagtcaacc agctggcgac 3081061 ttattcaggc gtaagcgcgg ccggcatctc cagaatcgaa aacggaaaac ggggcgttcc 3081121 caaacctgcc accatcaaaa aactggcaga ggccttaaaa attccttatg aggggcttat 3081181 gtacaaggct ggttacatcg aagaagtgca tgaagccagg gccccttatg aaacgaagtg 3081241 caagctgctt gaaaaagcgg aggcctatga cctgaaaaac cttgcgcttc ttgagaacga 3081301 aaagtggcaa tatctcaata aagaagattt gctcatgctg gatcattatt tttcgtttat 3081361 ttcagatgaa gcgaaaaaac ggtctgctga tgactgactc ttgatagaaa tgtgaggcga 3081421 tagaccatgt caccgttcgg acagcaatta cgggagctgc gccgcgcccg caaactgaca 3081481 gtgaatcagc ttgcggtgta ctcaggcatc agctcggcca ccatttcaaa aattgaaaac 3081541 ggcaaacgcg ggacgccaaa acccgccacg attaaaaaac tggcagccgt cctgaaagtg 3081601 ccgtacgaaa acctaatggc cgccgcaggc catattcagg cctttcctga agaaatccgc 3081661 gaagcatctg aaggctatca atccgtttat gaaatttacc agacggctgt cacacgcgga 3081721 gcggagcacc tcccgatttt caatagtcaa aaatgggaac atctctcaaa gcaggatatt 3081781 gaaaatctca gcaaatactt cgattttttg tcttcagaag caaaaaaacg cgcctcttcc 3081841 tcataatccc ctgtttctct ttctatattt tatcaatcac gcttgcatgc cctccctcgt 3081901 tatttgcgtt ataatagtga cagacgaggt gaaaagtatg aaccaatcag aaatgtgtcc 3081961 tagatttgaa aaagcagtcg acatcttaag taaacgctgg gtcgctttaa tcgtatttca 3082021 gctcttgaac gggtcgcagc gatttagcga aattgaagca gcacttccaa atctaagcgg 3082081 cagagttctg tcagaacggc tgaaagaact tgagcttgaa ggagtagtga agcgggatgt 3082141 catccctgaa actccggttc gcatcgaata ttcattgact gataaaggaa aggcactagc 3082201 acccatatta ggtgagattt ctaaatgggc gactgaatgg attgaccctt cctttcttga 3082261 ctaattgcta aaatggttct gatctcaaag acgagaaaag aaccgttttt tattttccag 3082321 gtgaaaaaaa gatatctcag ccgatatata gtacatccac acattacgtt tttaaaggag 3082381 accactatat gcgactgacg atttcccgca aattcagcct ggtatttttg acactgatcc 3082441 tgatcaattt acttgtaggc ggaataggcg ttcttaatat gcagcatatc attcaaaaaa 3082501 cagatgaaat caacacaaaa tggattgacg gcatcaaagg aatcacttca attaattatg 3082561 taaccgagca cctgtcttct aaagaaaagg actttctgat ttatacagac aaaagtaaaa 3082621 tggatacact tgatcaagaa atgaatcaaa tcatggaaga cattaaccaa aagctcgata 3082681 actacgaaaa aacgatctcc actgataaag agcagaaact gttcgagcag cttcaaacta 3082741 aagtgaatac ctatatggat attcatgcgc aaattatcga aagcggccgc acgaatgaca 3082801 tggacaaagc aagaggttta ttggttcaga ctgaggccag ctttgaggat atgaaaaaaa 3082861 caatcactca gcttgttgac ttaaatcaag aaggcagcaa cacagcggta aaagaaacga 3082921 aggccgtcta tcataaaggg ctcatttaca ctgctttgct tgtggcagca tcaatcctca 3082981 tcagcatttt catctggctt tatatcacgc gaaacattgt aaagcctatc attcgcatga 3083041 aggaatctgc caatcatatt gccgaaggcg atttgtcgaa cgatatggag gccctcaact 3083101 caaaagacga gctgggtgat ctgaatgaag cgctgcaaaa aatggtaggg aatctgagag 3083161 atattgtcgg atattctaaa gacatatcaa gccgggttct ttcttcttca caggtgcttg 3083221 caaccgcaac gaatgaaaca agatccggca gcaaacatat taccgagacg atgaacgaaa 3083281 tggctgaggg ctctgaacag caggcccaag acgcggtgac gattgccgaa tcgatgaatg 3083341 agtttaccga aagcattgat aaagcctata atcacggcat cacaatcagc gatacgtctc 3083401 aaaacgttct cgaactcgcg gtaagcggga acgaaaatat ggctacgtca ttacagcaaa 3083461 tgaaaaccat ccatcatatt gttgaagaag ccgtgcataa agtgagatca ctggaacagc 3083521 attctcagga tattaacaag ctcgttcagg tcatcaacgg gattgccgag cagacgaatt 3083581 tgctgtccct taacgccgcg attgaagctg cccgcgctgg agaaagcggc aaaggcttcg 3083641 ccgttgtggc agaggaggtc agaaagctgg ctgacggcgt ttctgattcc gtgcaggaca 3083701 ttacccggat tgtaaacggg acacagcagg agatccacac tgtcattacg tacttggaaa 3083761 gcagctttac agaagtcgaa aaaggaacgg aaaacctgac agacaccgga caggctatgc 3083821 agcatatcaa acaatccgtc acccatgttg cagacagcat taaggaagta acggatggct 3083881 tgaagcagtt aacaaaccaa tcgattacca tcaatcaatc gattgaaaat atcgcttctg 3083941 tatccgaaga gtctgccgcc ggcattgaag aaacattttc aattaccgag caatccgccc 3084001 attcgatgga tcaagtgctt ctaaatgctg aagagcttga gcagctggcc aatgagctta 3084061 atgagaagat gggtcagttt acgatttaaa gagaaaaaag aggctggact ccagcctctt 3084121 tttctattct atgcagctga ttgaacatgt ttcgccccgg ttcttttttt cttcaccgga 3084181 cttaatgccc gctccagcca agccatgagc aaatccgccc ctaccgccat caccgcagtt 3084241 ggtatcgctc cggctagaat aatcgcagtt ccgtttgttg cgtttgagcc gcgtacgatc 3084301 atgtccccaa ggcctccggc accgacaaat gtgccgatcg ctgtaattcc gatggcaatg 3084361 acgagagccg tgcgaaggcc cgccataatg acagaaagtg cgagcgggag ctcaaccatt 3084421 ctgagcactt ggaatttcgt catgcccatt gcttttccag attctaagta ggcatgttca 3084481 atactgataa tgcctgtgta cgtgtttcga ataatcggca gcagggaata cagaaataat 3084541 gatagaatca cggtatttgc gccgagcccc ataacaagca ttaagacggc cagcatagcg 3084601 agcgccggga ttgtttgaat aacgtttgtt acggcaaaca cccaggctga caaacggcga 3084661 aaatgcgcga tgaggattcc ggccggaacc ccgacgacag cggcaaataa aacgccgtaa 3084721 gccgacatga gaaagtggcg gccgaattca tccatgacgt aactgccatt ctgcgcgtaa 3084781 tacgtcatta actgttcaag cacgttcatt gacctcttcc ccctttcacg attcgaaata 3084841 gcgatgtttt tctaaatatt ccttggcaac gacagacggt tctttgagat tgccgtcgac 3084901 ttcatagtta agctcctgca tcgtggctgt gtcgattttt ccgagcattt tcttgatgat 3084961 gccttcaagt tcaggatgtt ctttgagcac cttttccgga acaaccggag agcagtcgta 3085021 cggcgggaaa aattgtttat catcctttag cattttgaga ccataggact tgattcttcc 3085081 atcggttgaa tacgcaagca caatgtccat ttttccgctt ttcaccgcgt cgtacacaag 3085141 gccgatctgc atcggatacg tgccgccgaa tgtcatgccg taggttttcg taaaatcctg 3085201 atagccgttt cctttgagct tcatccaata gttatcaacg cccagcttta attgcggcgc 3085261 ccatttttta acgtctgata cggtctctaa atggtattgg tcggccagct ccttgctgac 3085321 tgtaaaggca tatgtattat caaacccgta ggagtcatac cactttaaat catatctttt 3085381 tttaaactcc cgctgagtaa gcgccagcgc tttgtccgga tctttttcag gttccattct 3085441 caacgtgcct gtcagcgcgt ctcccgtata tcttgtggcc gcaatgtcga tttccccgtt 3085501 cattaaagcc tgctgctgca ccgcgttgga gccaagattt ttaatcgttg ttgttttgag 3085561 atcagtatgg tgttcgatca actggccaag catgctggcg atgatttctg attcgctcat 3085621 gctttgcgcg ccgattttaa tggtctggtc tgcagcagcg ctgagaccag gaagcgaaca 3085681 gccgctcagc gtcagcgttg ccgcaagtgc taaacctatc attaatttga gatattttct 3085741 tttcatgagc cgcctcctta tgacaattcc ttcaatctct gcatgccggc aggtgtcagt 3085801 tttcgttcag caactgccag cacataatca atcacaattg ccaatatcgt gacaggtacc 3085861 gcgcccccga tgatatattc cggctgatat aaattcagtc cgataaaaat gtaatcaccc 3085921 aatccgccgc ctccgataaa ggaagcaagc gtggcccagc cgattaagta aatcgtcgat 3085981 gttctgattc ccgccatgat cactggtgcg gcaagcggca gctccaccaa gcggacttgt 3086041 tcagccggcg tcattcctat tcctttacca gactcgagca gatttttgtt gacgccgcga 3086101 atgccggtat acgtgttgcg aagaatcggc aatacggaat agaaaaacaa agccacaatg 3086161 gccggaacct tccctacacc aaggagcggg ataaaaaaag cgaggatggc cagactcggc 3086221 agcgtctgaa tgatattgac aatgccgata atggtgccgg ctcctttttt cattctggta 3086281 agcacaaccc cgagggggac ggcaaccagc acacctaaga tcacagcaat gagcgatatc 3086341 gtaatatgct cgtatgtttt ataaagaagc tctcccccat tggtttgcaa aaattgaaca 3086401 atatgatgca tgacttatcg cccctcccta tgacaatgct gcgagctgct tttcttctcc 3086461 ccagagggag tcatacacga tgtcgaccag acttgccctc gtcacaattc cgatcaggcg 3086521 tcggtcttca tccacaacgg gaacatattt gacaccccgt tttaaaattt tgcggaccgt 3086581 gtcgcgcagc agtgtgccgc ccagtactgt gtatatatct tcatgtaaaa cttcactgac 3086641 gagattggcc tttttccggc attgatcaat gatttcaaca tcgacatagc cttgcagaac 3086701 gcgctcgtca ttgacgacca gcaatgaatc gacccgttcc tgcctcatca gctgaatggc 3086761 ctcagaaagc gttttatccg cggtgatcgt tacaggctgt gtgttcataa tctggtcaac 3086821 ccgttcaaca tccgggctgg atgactgaat cagccgctcc ttgccgataa attcctcaac 3086881 aaattcgtct gccggatttc ttaaaatgtc atcgggcgtt ccaacttgaa cgatttctcc 3086941 cgcttttaaa atcacaatcc ggtctgccag cttaatcgct tcatccatat cgtgggtaac 3087001 aaatacgatg gttttatgta aggttttttg cagtttttta aattcttcct ggagggaatc 3087061 cctcgtaatc gggtcgagtg ccccaaacgg ttcatccatt aagataagcg gcggctccgc 3087121 ggcaagtgcc cgtaatacac caattcgctg ctgctgcccc ccgcttaatt catgagggta 3087181 acggtctaca tattctggcc ccatatcgac caattttaaa agctcacgcg cccgctcttt 3087241 ccgctgctgc tccggccatt tcagcagttt tgggacgagt gagatattct gctgaatggt 3087301 catatgggga aacaggccga tctgctgaat cacatagcca attttgcgcc tgagctctac 3087361 aggatcctgg tccatgatgt tttcgccgtc aatgaaaatc ttcccggcgg aaggctcaat 3087421 taatcggtta atcattttca ttgttgtcgt ttttccgcag ccgctcggcc cgataaagca 3087481 gataaattcg ccttttgcaa tcttaagatt tacgttgttc acggcttttt tgccgccctt 3087541 gtatgttttc gagacatttt ctaatgtcag caaacatcgc acctccaaaa ttaagtttat 3087601 tcaatttgtt cagtttaaat ttaatttttc agacaattga atgcttccca ttatagaata 3087661 aagtttataa aataaaaagt ttacaatttg ttcatattat ttataaagta tgtgtaaacg 3087721 ctgatttacc cgcattgacg tgtgttgatc tccttattgc tccaatttcc tgccaaattc 3087781 tcttttgaca gcattttcgc cgtatcaaaa atgtggtata ttgacatcgg aattgttagc 3087841 tgaaaggatg aaaccgttgg agaaagatcc gttaacgatc attgaacaag ccgaggacca 3087901 ttttatagaa agaatcgcgg aaaacatgca tgcatttgga atgccctcta ccgtcggacg 3087961 agtgctgggc attatttata tgaatcgaaa accgatgacg cttacggaat tatctgaggc 3088021 caccggcatg agtaaaacac gtatgagcca ggtagtgcgg gaaatgcttg atgccaacat 3088081 tgccgagaag gtattcgaaa aaggcgtgcg aaaagattta tatgaggttg agcaggacta 3088141 ctatcaaaca tttatcacgc tgttttcagc cacctggagc aaagtcgtca gcaaaaacaa 3088201 aatgatgcat aaaaaactca atcgggagct gcttagcgtg ttggatgaag agcttactcc 3088261 tgaagcggaa gaaaaagtga atgagctgct gaaggaatta aaggaatggc tcgattatta 3088321 taattggctc agccgtttga ttgagttttt tgagagcgaa gacattttta aatatgtgcc 3088381 gaagccgtaa aaagttccca aattcaattc tgggaacttt tttaagtcca atccaaatgg 3088441 ttgaatatca aacttcaaga aaacaaacaa aataatgcat aatttacatt aatttattaa 3088501 ttatccattt tttgttgatt attctgacta gctattatat aatctttttg aaatgattat 3088561 attagcttag aggaggtaat ctacatcaaa aaaaagggaa ttattactgt aatgactata 3088621 tgtttcctat tattttcttc ttattacttt agcaatattt cacctcagaa tccactgttc 3088681 aaaaaaaatt ttttgcaaca attgtctccc caaggctttg gcttttatag taaaagccct 3088741 acagaagaaa acatttcatt tcacacaaaa gaaaatttaa agttacctaa tgcacttccc 3088801 aataattttt ttgggataaa aagagaagga agagttcagg caatagaatt aggcaaaatt 3088861 gtagagaata tcgatccaaa gaattggaaa acttgtgaaa acaacaactc ctgcacaaat 3088921 ttagagaaac aaataaagcc tattaaggtt ataaaaaatg aagattatat acatcttagc 3088981 aaaggagaat acctaatata tcgccaaaaa ccactctcat ggtattggat agactttaag 3089041 caaactacct cttttgaaag aaaggtgcta aaaataaaaa tagtatgaag atattaaata 3089101 gtttagaagg ttatattgac acctataatc catggaaaaa tacatatgca ctttttagaa 3089161 gtttacttgg tttctcaaca ttactagtac tattattcaa tagtactgat attttattta 3089221 gttatagtgc aaataatgtc acatgtgaaa atgtctatat ccctaccgct ttttgttttg 3089281 ctaaagaata tagtatcaat tttgagatta taagatactt aatgattttt atattaacct 3089341 tagtggttat agggtggaga cctagattta ccggtttatt tcactggtat atttgctata 3089401 gtattcaaac ttcagcttta actatcgatg gtggagagca aattgcaact gttctttctt 3089461 ttcttatatt acctgttaca ttattagatt caaggcgaaa tcattggaat ataaagaaaa 3089521 acaataatga atctttcaca aagaagacag tattgtttta tataatgaca ataattaaaa 3089581 ttcaagtttt tatcatttat ttaaacgcag ctttagagcg attgaaaaat aaagagtggg 3089641 cagaaggaac agcaatttac tatttctttt ctgatccggt gtttggatta cctgaatatc 3089701 aacttaactt aatgaatcca ctacttgaaa gcaattttat tgttgtcatc acttggttag 3089761 taactatttt tgagttgttc ttagcagcaa gcataatttc aaatatcaga ataaagagaa 3089821 ttgcccttgt tttgggaata ttatttcata ttgggataat attcagcatt ggtattgtaa 3089881 gttttggctt gatcatgata tcagcattaa ttatatatct gcatcctgta caacaaaata 3089941 tcactatgaa ttggtgttct cctttattta aatatatata tgtaaaagga aagagaaatt 3090001 tcaaaagaat aggaggtgaa tcagtcaagt ttcttacaaa attgtttcat agctaacatt 3090061 tagataatgg agaaataact taatggaggt ataataattt gaaaagtaaa ttacttaggc 3090121 tattgattgt ttccatggta acgatattgg ttttttcatt agtaggactc tctaaggagt 3090181 caagtacatc tgctaaagaa aaccatacat tttctggaga agattacttt agaggacttt 3090241 tatttggaca aggggaagtt ggtaaattaa tttcaaacga tttggaccct aaactcgtaa 3090301 aagaggcaaa tagtacagaa ggtaaaaagt tagtaaatga tgtagtcaaa tttataaaaa 3090361 aagatcaacc acaatatatg gatgaattga aacaatcgat tgacagcaaa gaccctaaaa 3090421 aactcattga aaatatgacc aaagcagacc aacttatcca aaaatatgct aagaaaaatg 3090481 aaaacgtaaa atactcttct aataaagtta ctccatcttg tgggctttat gccgtctgtg 3090541 tagcagctgg atatttatat gttgtgggcg ttaacgcagt tgcattacaa acggctgccg 3090601 cagtaacaac tgcagtgtgg aaatacgttg ccaaatattc ctcttcagct tctaataatt 3090661 ctgatttaga agcggctgct gcaaaaaccc taaaattgat tcatcaataa tccattataa 3090721 ttgagtgtct tgcggattgc tccgcaagac actttttcaa cgtgaaccgt ttaatttttt 3090781 gtaataatga tatgaagcta gtgttgaaat aactaatgct agaagaacta gcacaatcat 3090841 aataagaatt atatattctc ctgtaaaaaa tgaaagaaca gctattataa aaccacacac 3090901 tacaagtact ttagaggcaa agcgatttcc cagtttccaa acagtctcat cttttaatgt 3090961 ccaaggtgtc ctcaatccaa taagatggtt ttgttctgct agctgcatag aatttccacc 3091021 aataattaaa aagataccaa caccaagccc tattattaaa tcaatattca cttcgtatcc 3091081 taaacttatc aatagagttg agagttgtaa aatatataaa aggattaaca tattattaga 3091141 agctaggaaa agcaatgctt tatttttttg tgtagactta atagttaaca tataaaaagt 3091201 aagataataa ataagcataa caacaggtat aataaatatt gttaaaggtt tagatacaat 3091261 tgcagccggt ttatttcctg accattgtat cggtatttct tctggaaggt attgatataa 3091321 tataattgaa gtcaagaaac tcaaacatac aataattatg gaaattatat ttttcttcat 3091381 aaatcgttat cccctttatt tataaagtta agcatccaat ttattgagtc ttgaagtact 3091441 gttgtattta gagagtaata aataaattgt cctttgcgat ggtcacttat gacttccgct 3091501 tgctttaaaa tattcaagtg gtgcgaaata ctcggtttgc tgatattaaa atgctcagca 3091561 atatctcccg cagtcatatc ccctcctttt aacaaatcca aaatttttct ccttgttgga 3091621 tctgatatag ctttgaaaac attattcata gcgttttctc ctttacaaaa aaacatttag 3091681 acatttagat atttgtataa atgtattatt ttcattataa cttgaatttt tttaaaaaca 3091741 accctcaaat tggttataat atctgatttt tgtatttttt caaatactcg gataatccca 3091801 acgctggaaa atatgtttaa cagatactaa cacatgttgt ttatttaaaa aaaccacctc 3091861 tgttgtattt aaatagaggt ggtttttcta tcagctataa taaaatttcc ttttttcttt 3091921 ttaatcgggc ttaatgctcg ttcaagccag cccatgacca aatcggcaat caccgccatc 3091981 agagctgtgg ggatcgctcc cgctaatata atcgcggttc cgtttgtggc gtttgatcct 3092041 ctgacgatga tgtccccgag accgccagca ccgacaaatg tcccgatggc cgtaatgccg 3092101 atcgcaatga caagcgcggt gcgcaggccg gccattatga cagaaagcgc aagcggaagc 3092161 tcgaccatcc gcagcacttg aaattttgtc atccccattg cttttcccga ttcaagatag 3092221 gcgtgctcaa tactgataat ccctgtatac gtatttctga taatcggcag aagagaatac 3092281 agaaataatg acaatatcac cgtattagcg cccagcccca tgacaagcat cagcacggcg 3092341 agcatggcga gagccgggat ggtctgaatg acattcgtga ccgcaaaaac ccatccgctt 3092401 aatcttctgt atctggctat caggatgccg agcggaattc caacaatggc ggcaaataaa 3092461 acgccataca ccgacatcag aaaatggcgg taaaattcct gcagcacgta accgccgttt 3092521 tgcgaatagt atgtgccaag ctgctgtagt acttccatat gatccacctc ttttcttagt 3092581 caaaataatg atgtttctct aaaaattcct ttgctacgac agacggctcc ttcagcttgc 3092641 catccacctc ataattaagt tcctgcatcg tttccgtgtc gatttgccca atcagcttat 3092701 tgatcacacc ttcaagttcc ggatgctcct taagcacctt ttccggaatc accggtgaac 3092761 agtcatacgg cggaaagaaa cgcttatcgt cttttaagat tttcagatca tatgctttaa 3092821 tccgtccatc cgttgaataa gccaaaaccg catccatttt cccgtttttg actgcgtcat 3092881 agactagccc gatctgcatt ggataagttg tgccgaactc aaagccatat gtgctgacaa 3092941 agcctttata cccgtcgcct tttcgtttca gccaagcatt gtcgacgcct aatttatatt 3093001 gggaagcatt tttcttcagg tcagacacgg tgttaatatg ctccttttcc gcaaactttt 3093061 ttgttacggt gaaggcatat gtgttatcaa agccgtagga atcaaaccat ttataagaaa 3093121 agcgcttttg aaactcgttc tgcacaatgt tcagcgcttt tttcggatct ttctccgctt 3093181 ccttgccgag ggtgcttgtt aaatctgttc cggaatagcg cgtggctgaa atatcaatgt 3093241 caccgcccag catcgcttgg tgctgaacat agtttgagcc gaggtttttc actaaagcag 3093301 tattcaaatc tgtatcatgt tcaataagct gcgcgatcat attcgctaca atttctgatt 3093361 ctgtcatgct ctgcgccccg attttgatcg tatcgtcaga agcgccgcct agacccggca 3093421 gagagcagcc gcctagcagc atgacaaaga cgagagcaaa cgcgccaagc catttgattt 3093481 ttgtcatttt caacagtgcc aactccttac gatacttcct tcatcccttg caagcctttc 3093541 ggcgtcacct ttcgttctgt cacagccaga acataatcaa taataattgc cagaattgtg 3093601 acaggcacgg caccgccaat gatatattca ggctggtata ggttcagtcc gataaaaata 3093661 tagtccccga ggccgcctcc cccgataaac gacgcaagtg tcgcccagcc aattaggtag 3093721 atcgttgatg tgcggatccc cgccatgatg atgggaatcg ccagcgggat ttcaacgagc 3093781 cgaatctgct cccagccggt catgccaatt cctttccccg attccaggag gtttttattt 3093841 acacctttaa tgccggtata cgtattgcgc aggatcggca gtaccgaata gaaaaataaa 3093901 gcgacaatcg caggcacttt tcctacgccg agaagcggaa taaaaaaggc taaaatcgcc 3093961 agactcggca gggtttgcac aatgtttacg aaaccgataa ccgcacctgc gccttttttc 3094021 attctggtaa gagcaacgcc gagcggcact gcaacgataa tgcccaatac aacggctatg 3094081 agtgaaatat ataaatgctc tcctgtttta tacagcagct ctccgccgtt cgtttgcaaa 3094141 aaagtcatca tttgattcat cttaaaagag ctcctcccct ggtcagatcg tcatgagctg 3094201 gttttcctcg tcgccccaaa tggaatcgta tacgatatca acgaggctcg ctcttgtcac 3094261 aatccctgct aaatggttct gttcatcgac caccggaaca tacttgatcc cctgcttcaa 3094321 aatttttcgg actgtatcgc gaagaagcgc ccctttttga acggtatata tatctgaacg 3094381 gtatacatcg ccaacgatgc tcgctttttt gcggttttga tcaatcattt ccacatcaac 3094441 atagcccttc agcacgtttt gccggtccac aacgagcagc gagtcaacac gtttttctct 3094501 catcagctga atcgcctgag aaagcgtttt gtccgcagat accgtcaccg gcgttctgtt 3094561 catcatttgc tctacccgct cgatatccgg tcttgactga atcaggcgct ctttcccgat 3094621 aaattcttca acaaactcat ttgccgggtt tcgaagaatc tcatcaggtg tgccgacttg 3094681 aacgatttct cccgctttta atatcacaat cctgtcagca agcttaatcg cttcatccat 3094741 atcgtgggtt acaaacacaa tcgttttgtt taaggttctc tgcagttttt tgaattcttc 3094801 ctgaagggaa tcacgcgtaa tcggatcaag cgctccgaac ggttcatcca ttaaaatgag 3094861 agggggttcc gctgccaggg cgcgcagcac gccgattctc tgctgctgtc cgccgctgag 3094921 ctcatgcgga taacggtcta aatactctgg gcccatatcc acaagcttta acagctcgcg 3094981 cgcccgttct ttccgttttt cctcaggcca tttcagcagc tttggtacga gtgagatgtt 3095041 ctgctggatg gtcatatggg ggaacaaacc aatctgctgt atcacatagc cgatttttct 3095101 cctcagctca accgggtcct gttccataat attttctccg tcgataaaga tccttccaga 3095161 cgatggttct atcagtctgt tgatcatctt catcgtcgtc gtttttccgc agccgctcgg 3095221 gccgataaaa cagataaatt caccttttgc aatatctaaa tcaatgctgt tcacagcttt 3095281 tttgccgcct ttatatactt ttgacacttg ttccaatttc agcaatccgt gcacctccgc 3095341 aggtttcctt taaattttct gaaaagtata atccttatta tagtttgaac tttgtaaaat 3095401 aaaaagttta caatgtgttg aaattatatg ttatttatag attatttatt gttatgaccg 3095461 agacggaaag ggtgttctta caattactcc ggatacctcc cacttcctct gcattcagct 3095521 attttcaaca ccaggaagaa atatgatata ttgacaccat caattgccat ttgaagggat 3095581 gatcagctgt gaaaaaaacc gctctcgaca tcattgaaca tgctgaagag catctcattg 3095641 agaagattgc cgaaaatatg catacgtttg gaatgccttc aactgtcgga cgtgtgctcg 3095701 gaattattta tatgaatcga aaaccaatga ccttaagcga gctctctgag gcaacgggca 3095761 tgagcaaaac acggatgagc caggttgtcc gggaaatgat cgatgccaat atcgccgaaa 3095821 aggtgtttga aaaaggcgta cgaaaagacc tttatgacgt cgagcaggat tattatcaaa 3095881 ccttcatttc tttatttgcg gcgaattgga caaaggtcgt gagcaaaaac aaagtgctgt 3095941 ataaaaaatt aaaccgggag ctgagtgatc ttttacaaag ggacgggctt accccggaag 3096001 cggaagagaa agtcaatcag ctgctgaatg aattaaaaga atggcttcat tactatgatt 3096061 ggctgagcag gttgattgaa ttttttgaga gtgaggaagt ctttcggtat gtgccgaaaa 3096121 caaaagaatg cagctctcta aaataagaga gctgcttttt gcatcatgaa gttaagaccg 3096181 gaaacatgcc tttcagcccg gcaccaatca tcccgaccgc aaccacggct aagattaatc 3096241 ccatcagtct ggtaatcaca ttcatctcgg tttttccgag tttgctgctg ataaaagcag 3096301 aatagtggaa aaagagaaag gtcagggcaa taacggcggc tatgccgatc atgacagccg 3096361 cataatgacc aatgccgcta tgtccggcgg aaaggctcat cactgttgca atcgttccgg 3096421 gcccagcaat gatcggaatg gataaaggtg tgactgatat atccgctttt tccttgcttt 3096481 ccttatgttc atcatggtga agagattgca cgtgcgattc tttcgcattc aatagattat 3096541 aggcaatgcc gaaaatgaat atgccgcccg ccactcggag cgcgtgaatg ttgatatcaa 3096601 acagtttaaa gataagatga ccgaaaacca aaaaagctgc gagaataaaa aaggataaaa 3096661 tagctgcctt ccgggcaatc gcttttcttt ccgctgcagt atagccttct gtcagcgtca 3096721 gaaatatcgg tacgtttccg atcggattcg atactgcgaa taaagaaatg aagacgtgaa 3096781 cgataaatga gaacatcata tacctccttg ttgatagtct ctgcacagga aatagaatga 3096841 ttctccaccc ttttacccgg aggcgatttc ccggtaaacc tttatagcct gtcagaaacg 3096901 cgccatgcta caatgaagtg acaaattgaa taggaaggac gtatacagat gttcaaaaaa 3096961 attgcggcag atgccttggg cttatctgat atcggaaaaa ttatcgaacc tcaggactat 3097021 gacaaaacag acgcagatga ctatgtcatg catgaagata atgagaaaat ttatttcttg 3097081 attaaaacaa aagcagacga gtattgcttt acgaacctgg ccctgatcca tgtggacggc 3097141 gaacgcgcca cttcctcaaa acgaacgttg aaacgctatc cttattcgca atataaaatc 3097201 tctgacgttt ttcttgaaac tgccggaaaa gtggatttgg atgttgaaat taagttcaag 3097261 ctgggcggtg aacaattcga cattgatgtc cacaaagacc agattgaaaa gttaaaagac 3097321 ctttataaag cactgcttcg catcgctgaa acaacctatg aaaatgacat tttaatcaat 3097381 caagcggagc aaagcttaga taaagcagtg acgattcttc accatacccg ccctgagcac 3097441 gtcaatattg aaacgcaata caaagagctg accgaattcg gattcacttg gctgacatcc 3097501 gttcgctcgc agtatcatat taaggatttt ggggatgtat ttgagaaata tattaataac 3097561 tagataaaaa aagacacagc tgctatcgtg ctcgtgtctt tttttgtatg aatattgatt 3097621 actttacaac ttttttcttt tataataaaa ctattagtct attttcccta tattacagat 3097681 aaaggagtta ttttatgtat tgtcctcaat gcggccatca aacagatggc ggaaattttt 3097741 gtgagaaatg cggatcaccg ctccccggtc aatcaggcca ccagcatgca gctcaaactg 3097801 gagccgctgc aaagcaagca gcaaaacagt tcggttcatt tgtcttatcc gtcctgaaac 3097861 gcccttatca ggaatgtaaa gcaacaggcg gagaacagct gatcagcgca atcattacga 3097921 tggttctttt cagtttgctg acccctttga tgttttatat tcttttttca gacggtcccg 3097981 gaagcgtaag ctttacagca atcttcttag agccaaccat ttattttatt ttatttctat 3098041 ttggcctgca tgcatgcatc tttttcgccc tgaaaatcgc gggaaaccaa gtgtctttca 3098101 aggattcatt ctcaagattc ggagcatttc ttattccttt tacggctatt ttgattcttg 3098161 cccttttctt ctttttatta catacagaca tttgctttac catattagcc gttggtttaa 3098221 tcggtgcatt cttcgccatt cctcctgcga tgctgagcag ttaccagcat tcatataaag 3098281 ggaaggttga tttcatttac tcaacgattg tgatttatct gatcatctgc gttacatttc 3098341 agcttattat cgaacactat gtcaaagaaa ttttccgtta tatgctcttt taaaaacaac 3098401 cccatcacct gctggtgatg gggttgtttt attgaataga cgttaagtaa attcttccgt 3098461 tcttcactac gccggtgtag gtccagttat atgttctgag ctttggactg ccgcctgatt 3098521 ttgtgatata gaattcttca tacgtcttaa tcgtgatagc cgacccattt tggctccagc 3098581 ttttcacttc atagttatta aagtcttctg ttgtcccctc tttatttaat ttcgacacga 3098641 gatgctgctg gtcggaataa agggaactgc ctttttcaag gctgtcttcc atcagtgaga 3098701 aattattttg attcacggca tctgcctgac tttgcagata actgcccata aataatgtca 3098761 cttgttcatc tgtaacatcg ccgcttgcag agctttcact gcctttgttt ttcgagccag 3098821 cccaggcgga agtgtatgtc tctggtttat catttttgat tttctttata tttgtgcctg 3098881 cagattcgaa tgttgattct gcatcttcga aaatccactt tttctgtttt ttatcatatg 3098941 aaagaagata ttcataactc ggactgtcgt cagtcatttc agactttgta tagtcgttat 3099001 acgaagaaga ctggtgaagt tcttttcctg ttaccgatac ctgccacgtt ccgtcgtttt 3099061 tctgagagag ggcaaatgtg tccaggtcaa aatcagtttc caagtatcta tcttttaagt 3099121 atgaatccgc gcttttcata gaatcgacgg tgtccttcgt ctccgccttc caattggcac 3099181 ttgcctctgt catctgggct gtattcccat cagatagagc tttggagtat tgttttgttg 3099241 ttttgacaat tgtgttcata atctgttcct gtgtatcttg atcaggaatt aacgttaact 3099301 ccatttcttt atcatcgatc ggaacgccgg cagtttttgt ttttccccac ggaaattctg 3099361 cctcgactga agctgtcatt gatccatctg tcagcagcgg accatatgtt acggatttga 3099421 acggatcttt atgaattgat ttaccgttaa tcagcaaatc tcccttcccg ctcttgatgt 3099481 cattcgctaa gctgaatgtc acatcgtctg cttccaatga gagatcaaca cgaaagctgc 3099541 tatcgccaat cgcctgaatg tcttcctttt tcacaaggtc aacgacatcg tttttcagtt 3099601 tggctgagac tgtatattcg ccgggaatgt acggaccaag ggtttgtgct tgatctgctt 3099661 tctttacaga tccggcttcc tctttattga catatagatc ggtattttta taattgctgc 3099721 tcacttcaaa ataaacaggt gctaccttta agtcataatg gtcaaatacc agcaggcttt 3099781 tcccgtcttt ttccgcatat acgatatcct tctgggctgt ttcatcacgc agcgatgcaa 3099841 aaagttcatc ttttttgtct ggatgatcct tcaaatatgt aagaaacggt tttacattat 3099901 ttttagtgag tttaagattg tcatttaccg gtgtaagcag agtcgcgatt tggtcctgat 3099961 ccccatcatt tacggcctgt tcaaacttgt ctactaacct atcctttgaa gtaaaatacg 3100021 ctccggtttt atatgcggcg aataatataa cgcacgccgc ggcaatgctg ctccataaaa 3100081 tgatggtttt cttagggatc ggttttcgcg gagcctgcct cgtttctgca gtgctagctg 3100141 tttcttgatt tgcctgtttg ctgccccctc cgatcggggt gccgcattgt ttacaaaact 3100201 tggctccttc attattctgg gagccgcaat tcttacaaaa taacatgact ttcctcctat 3100261 tctactaatt tgataacatt tactgctttt catattttat aataaaacag aatgaaattg 3100321 ggaacgaatg aaaaaattaa atgtctatca gactaaaaag gtggaatgaa tatgcaaaag 3100381 ctcaggattg aattaggaga agaaacaaat gacgaattat atgatctatt gctgctcgcc 3100441 gatccatcga aagacattgt agatgaatat cttgagaggg gagaatgtta cacagcttgg 3100501 gccggtgatg agcttgcagg ggtttatgta ttgctaaaaa caaggccgca aacagttgaa 3100561 attgtaaata ttgcggtaaa agaatctctt cagaagaaag gctttggcaa acagcttgta 3100621 cttgacgcca tcgaaaaagc gaagaagctg ggggcggaca cgattgaaat cggaacgggg 3100681 aattcgagca ttcatcagct ttccctctat caaaaatgcg gattccgcat tcaggcgatc 3100741 gaccacgatt tctttctcag acattatgat gaggacattt ttgaaaacgg gattcaatgc 3100801 cgcgatatgg taaggcttta tttggatctc tgaaagcata aaaaagccgc cgagagaaaa 3100861 tcccggcggt ctttttatta cttgtttaag ttgtagaaag agttgatacc gtggtattga 3100921 gcagtttcag ccaactgatc ttcgatgcga agaagctggt tgtatttcgc aacacggtcc 3100981 gtacgagacg gagcacctgt tttgatttgt cctgcgtttg ttgccacagc gatgtcagcg 3101041 attgtgctgt cttcagtttc accagaacgg tgagagataa cagctgtgta gcctgcgcgt 3101101 ttcgccattt cgatcgcatc gaatgtttca gtcaatgtac cgatttggtt tactttgatc 3101161 aggatagagt tgcctacgcc gtttttaata ccttcagaaa gttttttcgt gtttgtaacg 3101221 aagaggtcgt caccaacaag ctgaactttt ttgccaagac gctcagtaag aagcttgtgg 3101281 ccttcccagt cgttttcgtc aagtccgtct tcgatcgaga tgattgggta tttagaaaca 3101341 agctcttcat accagtcaac catttcagca gatgttttca caacgccttc gccagacaga 3101401 tggtatttgc cgtcttcttt gttgtagaac tcagaagatg cagcatccat agcaagttta 3101461 acttcttcgc caggtttgaa gccggctttt tcgattgctt caacgattgt ttgaagcgct 3101521 tcttcgttag aaccaaggtt tggagcgaat ccgccttcgt cacctacagc agtgtttaag 3101581 ccttttgcgc ttaatactga tttcaggctg tggaagattt gagcgcccat gcgaagtgct 3101641 tcacggaagt taggagcacc tacaggcatg atcatgaatt cttgaatatc cacgttgtta 3101701 tcagcatgct ctccgccgtt tacgatgttc atcatcggta caggaagcgt ttttgagttg 3101761 aatcctccaa ggtattggta aagaggaatc tgtaagaaat cagcagcagc acgcgcacaa 3101821 gccatagata cgccaaggat tgcgttcgca ccaagtttgc ctttgttttc agtaccgtca 3101881 agctcgatta aaagctgatc gattgcgttt tgttcagtta catcaaagcc aagaagctct 3101941 ggagcaatga tttcgtttac gttgttaaca gctgttaaca cgccttttcc aaggtaacgg 3102001 tctttgtcgc cgtcacgaag ctcaaccgct tcgtattcac ctgtagaagc tccgcttggc 3102061 actaatgcgc ggccgaaagc tcctgtttct gtatatactt caacttcaac tgttgggttg 3102121 ccgcgggagt ctaatacttc gcgtgcataa acatcaacaa tgtatggcat gagttttgtc 3102181 tctccttttg attttcaaat tatttttgaa ttaaagatgt tcctgtcatt tctttcggtt 3102241 tttcaacacc aagaaggtct aataacgttg gtgcaaggtc gcctaggatt ccgccttcac 3102301 gcagcgtaat gccttctttc gttacaatca cagggactgg gtttgttgta tgcgcagtgt 3102361 gcggttcgcc tgattctgta atcagaatgt cagcattacc gtgatcagcg gtaatgatag 3102421 cgtgtccgcc tttagcaagg atcgcgtcaa cgacttcgcc caagcattcg tccactgctt 3102481 caattgcttt aattgttggt tcaaccattc cggagtggcc gaccatatca gggtttgcga 3102541 agttaagaat gatcgcgtca tgcttgtcag cttcaatttc tttgacaagc gcgtctttca 3102601 cttcatacgc actcatctca ggcttcaagt catacgttgc aactttaggc gagttgatga 3102661 gaatacgctc ttcacccggg aattcagctt cacggccgcc gctcataaag aacgtgacgt 3102721 gcggatactt ttcagtttct gcaattcgaa gctgttttaa cccgtgctga gataatactt 3102781 ctccgactgt gttatcaaga tttatcggtt taaacgctac atagccgtca actgtttcac 3102841 tgaagtgagt caggcagacg aaatacaggt tctttggata attctcgccg cggtcgaagt 3102901 cacggaagtc tttgtttgtg aacgtgttgg aaatctggat ggcgcggtcc ggtctgaaat 3102961 tatagaaaat cacagaatcg ccgtcttgga ttttcgcaac aggctcaccg ttttcttttg 3103021 tgatgacaga tggaatcacg aattcatcgt agataccatt tgcatatgaa tcatcaacaa 3103081 catccagggc gctgcggtaa gatgggcctt cgccgtacgc cattgcgcgg tacgcttttt 3103141 ctacacggtc ccagcgtttg tcgcggtcca tagagtagta acgtccggaa atgctggcga 3103201 tttcacctac accgatttcc ttgatttgat cgttcaactg gttgatgtac gttttcgctg 3103261 tctgcggacc tacatcacgg ccgtcaagga agccatggat ataaaccttt gtcagccctt 3103321 cttttttcgc aagctttaac agtgcgaata aatgattgat atggctgtgc acgcctccgt 3103381 cagataaaag accgaacagg tgcaaggctt tgttgttttc tttcgcgttg ctgatcgcgt 3103441 caaggaatgt ttgattgcgt tcgaactctc cttcacgaat ggcaacattt acgcgtgtta 3103501 agctttggta cacaatacgt cccgcaccga tatttaagtg acctacttcg gagttcccca 3103561 tttgcccttc aggaagacct acagcctcgc ctgaagcagt caaagtttga tgaggatact 3103621 ggttccaata gcggtcaaaa ttcggttttt tcgctaaagc gactgcgttc cctactgttt 3103681 cgttacgtaa tccgaaccca tcaagaatga tgagtgcagc tggtttttta ctcatattga 3103741 ccttcctcca ataattgaac gaatgactgt ggctcaaggc tcgcgccgcc gaccaaagca 3103801 ccgtcaatat cggactctgc catatattct ttaatgtttg caggctttac gcttccgcca 3103861 tattggatgc gaagcttgtc tgcagcttct tggctgaagc tttcagcgac ggttttacgg 3103921 atatgcgcac acacgtcatt cgcatctttc gctgtagaag atttgcctgt tccgattgcc 3103981 cagattggct catacgcaat aacagaagca gcaacttgtt cttcagaaag accagcaagg 3104041 ccttttttca cttggtcagc aacaagatca tttgttttgc cggcttcacg ctcttcaagc 3104101 gtttcaccta cacagatgat cggcacaatg ccgtgtttga aagctgcgtg tgcttttttg 3104161 ttaactgttt catcagtttc agcgaacatt tcacggcgct cagagtggcc gatgacgcag 3104221 tagtcaacgc caaggtcttt cagagcaacc gggctgattt cgcctgtgaa cgcgccgctt 3104281 tcttcgaagt gcatgttttg agcgccgact tttaggtcag tgcctttcac agcagaagca 3104341 agcttttcta agaaaagcgc tggcgcgcaa acaacagctt cagctttgtc tgctgctgga 3104401 atggaagatt tcacttcttc aacgaagctg acagcttcgc cgagtgtttt gttcattttc 3104461 cagttaccgg cgataattgg ttttctcatc tgttccactt ccttatagca gttttgagat 3104521 tatttatcgt tcagtgcagc tacccctgga agctctttgc cttccataaa ctcaagggat 3104581 gcgccgccgc ctgttgagat gtggctcatt ttgtcagcaa ggccgaattt ttcaaccgct 3104641 gccgcagagt ctcctccgcc gatgacagag tatgtatctt tcgcctctgc caatgcttcc 3104701 gcaaccgctt ttgttccttg agcgaacaag tcgatttcga atacgcccat tggtccgttc 3104761 cacacgacaa gtttgctgtt tttgatgacg tcagcatacg tttcgcgtgt tttcgtacca 3104821 atgtcgattg cttctaaatc actagggatt tcagagatcg gcacaatttt cacgtttgca 3104881 tcgttagaga aatcatctgc aacgagtaca tcttcaggca tgtagaagtt aacgcctttt 3104941 tctttagcgc ggtccataaa tgatttcgca agctcgattt tatcctcttc aagaagagat 3105001 ttcccgactt catagccaag cgcttttacg aaagtataag caagacctcc gccgatgatc 3105061 aggttgtcta ctttatcaag aagactttcg attacaccga ttttgtcttt tactttcgct 3105121 ccgccgatga tcgctgtgaa cgggcggtca ggattggaaa ccgcttttcc aagtacatca 3105181 agctcttttt ccattaagaa acctgcaact gctggcagat gctcggcaat tccagctgta 3105241 gatgcgtgag cacggtgggc agcaccgaat gcgtcattta catatacatc tgcaagctca 3105301 gcaaatgctt ttgcaagctc aggatcattt ttctcttcac caggatagaa acgtacgttt 3105361 tccaatacaa gaacgtctcc gtccttcatc tcagaaattt gtgcttttac agcatcgccg 3105421 tatgcttcat ccgctttttt cacttctttg ccaagcagtt cgccgagacg tgcagcgaca 3105481 ggagttaaac gaagctcctc aaccacttcg cctttcgggc ggcctaagtg gctcgcaaga 3105541 aggacttttg cgccttggtc tgcaaggtgt ttgattgttg gaagcgcagc acggatacgt 3105601 gtatcgtctg ttacttcccc gtctttcatt ggaacgttaa agtcaacgcg gcagaataca 3105661 actttgcctt ttacgtcgat gtctttgaga gtttttttat tcatgcctag gagatcctcc 3105721 ttcaaaatgg tttgcataca gcacgaaaaa cgtgaaaccg tctgttcaag cgataactcc 3105781 gctagggcag atcgcagtct ttttcggcac agggcagttc gtctaaaagc cagggcagcg 3105841 gccttaggcg aaagcgccgg caaagctgct taaaacgcgg tcgtttctct atcacagagc 3105901 gttttctgaa agccggtctt catggaaaaa gggaaaggga gtccgtcccc ttcccttgtc 3105961 cgctttcatt atagcgcttc tattcgaaag aaccaagtca ggtccttttt cagctataaa 3106021 ttaaagacct ttttttgcga tgtaagctgc aaggtcaaca acgcggttag agtagccgct 3106081 ttcgttatcg taccaagaga ttacttttac catgctgcct tccataacca ttgtagaaag 3106141 agcatcgatt gtagaagagt ttttgtttcc gttgtagtcg ccagaaacta atggctcttc 3106201 gctgtagcca aggattcctt taaggtcgcc ttcagccgct tctttaagag ctgcgtttac 3106261 ttcttcagct gttacttctt ggttcagttc agcaaccaag tcaactagag aaacgtttgg 3106321 agttggaaca cgcattgctc caccgttcag tttgcctttt agttcaggaa gaactagaga 3106381 aactgcttta gcagcaccag ttgatgttgg gatgatgttt tcagctgctg cacgcgcacg 3106441 acggtagtct ttgtgcggaa gatcaaggat ttgctgatcg tttgtgtaag agtgaacagt 3106501 tgtcatcata ccgcgtttga tgccgaattt atcgttaagt acttttgcaa acggcgcaag 3106561 gcagtttgtt gtgcaagatg cgttagagat aacatcgtgg ttagccgcat cgtatttatc 3106621 ttcgttaaca cccataacga ttgtgatatc ttcttcgtta gcaggagcag agatgattac 3106681 ttttttcgcg ccagcttcta agtgtttcgc agcgtctgcg cgttttgtga agaaaccagt 3106741 agattcaact acgatttcaa cgccttgttt gccccagcta agtttagcag gatcgcgttc 3106801 tgcagaaact tcaattgttt tgccgttaac aacaaggttg ttaccgtcaa ctgaaacttc 3106861 agcgtctaat tttccgtgta cagaatcata ttgtaaaagg tgagccagca tgttagcatc 3106921 tgttaaatcg ttaaccgcta ctacctcaac ttcaggattg tttaatgctg cgcggaatac 3106981 gttacgtcca atacgaccaa aaccgttaat accgactttt actgccatga ttgtttcctc 3107041 ctttaaataa gtgagagata tttatattga gggattattc atcccttaat aacttctttg 3107101 cggctccttc gtctgtgacg agaaccgtgt tgcgtggctt tttaaagtaa gcctcgatcg 3107161 cttcggcttt tgatgatccg cccgctaccg caataatatc ggggatggcg tctatgtcat 3107221 ccagctgcat tccgacagaa tgcactttgt gaaccacttc gccgtccgcg ttaaaatagt 3107281 agccgaacgc ttccgtcacc gcgtcgttat catctatttt ctttaaatct tctaaaggcg 3107341 tgtttctgcg ctgagccata gttttagctt cgccgattcc gtgaaccagc atactcgctg 3107401 atttaatggt gttcagcacc tctttgacag aaggctcttc aataatagat gaataggcgc 3107461 cttgtgacag ctgtcccgga acaaacaaaa gccggtaagt gcctgaagcc ttctccgcca 3107521 tatgcgcgca tatggtgttc gcctggtttt tcacgtcttc gcctaaaccg cctcttgcag 3107581 gcacaaacaa aagctcgcgg tttttagaat ccggcgtcat catttcggcg acagcttcaa 3107641 ttgtcgtacc gccagttaca gcgacgatat ttttgcctga aaatcttttt ttcatacatg 3107701 cgacagccgc tcttcccatt tcttttttga cccatgggga ttgatcgctg tctccggata 3107761 cgataatggc atcctttaga tttaaacgtt cttttaatgt cttttccaaa agagtcaaac 3107821 ctaaaacatc tttcatcgta tcttccaaaa cagaaagcag ttcatagccc tcttctgtca 3107881 atgtcatgcc gtttgtctta atatcgacca ggttctgttc ctttaaaaac tgaacctcgc 3107941 ccctcagcac acgctcgctg attccgagac tggcagacag gcttcttcgc ccgatgggtt 3108001 ctgtcagcct gatatactgc aagatttcaa acctcttttg cataacgagc agaagatcag 3108061 gcaataattt tttttgagct tgtattaact ggttcatgac tcaaacgttc cttccttttt 3108121 tgctggacat tatatgtccc gctatgacaa aaaacgtccc gtcatagcca aaaaaaatca 3108181 tttctgcttt ctttaattat tttaacaggg tggaattgtt tattcaactg ttaagagcca 3108241 attcatcgac aatattcgca gagttttcat gccgcgtcgt tttatccagc aatattttat 3108301 cctatatatc tttatcttat acagaaagcg ccaaatggtg catcccaata taaacagccc 3108361 ttcccgtaga aagggctgtt tcattaaagc gttttcattt tatccaaagc ttttcaattt 3108421 cctcgagcga tttgttcttc gtttctggac agatcgtaac gacaaacagg aaacaaagga 3108481 tgttaatcac cgcaaagatc caaaatgtat aggcgagccc gaaagaatcg atcatcattg 3108541 gcacaaactg tccgatcgcc cagtttgctc cccataaaaa gatggtcgca atgcccgcgg 3108601 cccgcgcacg cagatggttc gggaagattt cagaaatcat aatccatgtg atcggtccga 3108661 ccgagacaca gaaagcagcg acaaaaccta atataaggac gatcatcatg atcccgcttg 3108721 ttaactcaaa ataaaacgac gtcccgatta aaatcataaa aatagccata aaagcagaac 3108781 cgatggacat cagttttttt cgtccgactt tatcaatcag caacaccgca ataacggtaa 3108841 aaataacttc tacaaccccg acgatacaag tcgtcacaaa tccggcgttt tgcccgaatc 3108901 ccatcatttt aaagatttcc ggcccgtagt aagtaatcgc gttcatgccg atgacttggt 3108961 taaacagcgc cagcaggatt ccaatgacaa gcgcctttct gagacccggc ttaaacagct 3109021 gggagagcga ccccatttgt tctattttta aagagttctc aatgttcttt aattcttctt 3109081 ttgcaacagt ttctccatta atacgtgtca ggatctttaa agcttcattt gttttgcccg 3109141 ctttcgccag ccatctcgga ctttccggga cgacgagcag gacaaggaaa aaaatgacgg 3109201 atggcaccat tccataagca agcatccatc tccagccggt gtgcacgccc cattcgtatg 3109261 ttccggaccg ctgcacagct agattaataa agtatgttgc ggaaataccc agtatcgtaa 3109321 agagctgata taacgaagat aaacttccgc gtatagcggg cggtgccgct tctgtaatat 3109381 acgtaacaga gagcgatgag cccatcccga ttcccagccc cccgataatc cttgcaatga 3109441 ttaaggtgga cacgtcttga gaaagcgctg aaacgattgc tgatatcgca aataacaaag 3109501 cggctgtcat taaaattttt ctccggccga atctgtcact taaaaatccg gatatcccga 3109561 cgcccacaac tcctccaatc ataatgcttg aaatgacaag tccctccata aacggactca 3109621 ggctgtataa atctttcaga aaaccgatgg cgccagaaat cactgccgtg tcatagccat 3109681 acaataagcc gccaagcccc gccgcacatg agatcaaaat gacaaatccc attgaatggc 3109741 ttcttgttac aggaacattt ggttctaatt gagttggagt attcttcatt tccctgccct 3109801 cccgaatgtt gagtaaagcg ttttcattta aaccttcaat tgtacgtact tatattaaaa 3109861 tttaacgaaa attacattta attagtacgt acaaatatag aataatcttg tttgcatttt 3109921 ctgtcaatgt tttcttacaa agaacgctgt gatatactga aatttgtccg tatacatttt 3109981 ggaggaatgg atatgttacc aaaatacgcg caagtaaaag aagaaatcag ttcttggatt 3110041 aatcaaggca aaatactgcc cgatcaaaaa atccctaccg aaaacgaatt aatgcagcaa 3110101 ttcggcgtca gccggcatac catccgcaaa gcgatcggag acctcgtatc acaaggtctg 3110161 ctgtacagcg tgcaaggcgg aggcaccttt gtcgcttcac gctctgctaa gtcagcgctg 3110221 cattccaata aaacgatcgg tgttttgaca acttacatat cagactatat tttcccgagc 3110281 atcatcagag gaatcgagtc ctatttaagc gagcaggggt attctatgct tttgacaagc 3110341 acaaacaaca acccggacaa tgaaagaaga ggcttagaaa acctgctgtc ccagcatatt 3110401 gacggactca tcgtagaacc gacaaaaagc gcccttcaaa ccccaaacat cggctattat 3110461 ctgaacttgg agaaaaacgg cattcctttt gcgatgatta acgcgtcata tgccgagctt 3110521 gccgcgccaa gttttacctt ggatgatgtg aaaggcggga tgatggcggc ggagcatttg 3110581 ctttctctcg gccacacgca tatgatgggt atttttaaag ctgatgacac acaaggcgtg 3110641 aaacggatga acggatttat acaggcgcac cgggagcgtg agttgtttcc ttctccggat 3110701 atgatcgtga catttacaac ggaagaaaaa gaatcaaaac ttctggagaa agtaaaagcc 3110761 acactggaga aaaacagcaa gcacatgccg acagccattc tttgttataa cgatgaaatt 3110821 gcgctgaagg tgattgatat gctgagggag atggatctta aagtgccgga ggatatgtct 3110881 attgtcgggt acgatgattc acatttcgcc caaatctcag aagtgaaact aacctctgtc 3110941 aaacatccga aatcagtgct tggaaaagca gccgccaaat atgtcattga ctgcttagag 3111001 cataaaaagc cgaagcaaga ggatgtcata tttgagcctg agttgatcat tcgccagtcc 3111061 gcacgaaaac tgaatgaata aaaaaagcaa tgtatgggtc tccccgctac attgcttttt 3111121 ttatagctgt tatctgtttt tccaaacgtc agcgatgatt tcaaacgaac gcattctgtc 3111181 tgcgtgttca aaggtttctg agttaaccat aatttcgtca gcctgtgtcg ttttgacgaa 3111241 atcttcaagc ttcgccttca cttcttccgg acctccgaca atcgtggagc tcagctgctc 3111301 attgaccatc gctttttcat acgggctcca gatttggtcc atatcctcaa caggcggttt 3111361 aagctggtta ggcgtaccgc ggacaagatc aagaaacctt tgataatggg aagtcgcaag 3111421 gtgctgcgct ttctcgtttg tatctgccgc gataatggtg acaccgacca tcgcatacgg 3111481 ttcgtcgagc acgtctgacg gcgtgaagga attgcggtac agctccaaag cgggaaccgt 3111541 attcgccggt gagaaatggg ccgcgaacgc aaacggaaga ccaagttcgc cagccagacg 3111601 ggcgctgaag ccgcttgagc ccagcagcca aatcggcaca tctatgccct ctccgggaat 3111661 ggcgcgaact tgattgcgca catttcctga cggtttaaaa taattgcgca gttcctctaa 3111721 ttgttctgga aaatcctccc cgctgttgat gtttctgcgg agcgctctgg ctgtcaattg 3111781 gtctgttccc ggcgcacgtc caagccccag atcaatccgc ccgggataca gtgtttccag 3111841 tgtgccgaat tgttcagcaa tgactaatga agagtggttg gggagcataa tgccgccgga 3111901 accgacgcgg attttcttcg tgcctccggc aatatggcca atcaaaactg cggtggcaga 3111961 gcttgcaaca ccttctatat tatgatgttc agcaagccag taacggtgat agccccattc 3112021 ctctgcccgg cgcgccaagt ccatgctgtt tcggaatgat tctgcaatcg ttcctccctg 3112081 aacaaccgga gataaattca agacagaaag caaggtatct ttgcgttggt tgttagacat 3112141 attgttctcc tttgcaaatg tgttatcagt aaacagccca aagctgtcag gtcatgattg 3112201 aaagaacttc tatcacacca taacacaact gcattcagga ataaaagaat ttgattcgat 3112261 gaaattcgaa caatataaaa cgaacggttt ggaacattat tctgctccaa acaactcctt 3112321 agccatctca ataaagagct tagccgccag agaagcctcc tttagcgacg gaacagcaag 3112381 ctgcacatca cggtatacct gcgggtccaa ttccctggtc accacatgct ctggcagcgg 3112441 catccccgac atggacattt ctgataaaat ggccaggccc aggccttctc tgatcatact 3112501 gatcgaggtg ttgatgttat agaccgtgaa agctgggtgc agcgtagcac ccgcctgcct 3112561 gaacatatcg ataaatggtg attcatagcc gccgtcacag acgatcatcg gttcatggtc 3112621 aagatctttc agcgtaatgg ctgaatgact ggcaagcggg tgatcgtccc tgagcacgac 3112681 agccattttg tcttttttca aatgaatgta ctccatctcc tctgttggat acagaagaat 3112741 cccaacatct atcatccgcg tatgaagcca ctccttgact tcatttacag ttccctcgtg 3112801 cagcacgagc tcaagtttcg gatatttttg tttaaattca ctgatcagct tcggcataaa 3112861 ataagccgag gcagttgaga atgtgccgat atggatcgtt cccagttcaa gccctttttc 3112921 cgctgctgct acctgctcaa ctttttcaat gccttttaag acttctctga tgtgtactaa 3112981 gatctgtttt cccgtatccg tcagcatcag gccattgcgg cggtcacgaa tgatcagctt 3113041 tacatcaagc tcagcttcga tcgcagaaat cgcatggctg acagccggct gtgtcatgtt 3113101 cagcgcctga cccgcttttg taaagcttcc cgtttcagct attttcacaa aaacctttaa 3113161 ttgagtaatg gtcataacaa tttacttatg ctccttataa aaaagattca ttttatttat 3113221 cttatgttct accgtatcat atgatggaaa agttctacaa ggagtgaatg aacaatgaag 3113281 cagctcccaa aaacgcggac agctctcctg ctcgcatttc tcgtcatcat gtggggcgtc 3113341 aattggccgc tgtccaaagc cgcgctcgcc tattctccgc cattattgtt cgcgggcatc 3113401 cgaacgctga tcggcgggct tttattagtc atagtcgcac tgccgcgtat tcataaatta 3113461 cgcttaaaag aaacgtggcc gatttatctt gtttctgctc ttttaaatat tacattattc 3113521 tacggcctgc aaacgatcgg gctgaattat cttccggccg gcctgttttc tgcaatcgtc 3113581 ttcttccagc ctgttctgat gggtgtattt tcttggctgt ggctcggcga atccatgttt 3113641 gtaatgaaag tgattggcct catcctcggt tttgcgggag tagccgtcat tagtgctgcg 3113701 ggctttggcg ggcatatttc tgtcattggg gttctgctgg ctctcggctc cgcagtcagc 3113761 tgggcgctcg ggacagtata tatgaaaaaa acaggcagcc gcgtcgattc catctggatg 3113821 gtcgctctgc agctgacgat cggaagcgtg tttctgctta tctccggctt ttggacagaa 3113881 agcttttcgg cgatccaatg gacagctccg tttattacga gcctgctgtt catctccgta 3113941 ttcgttatcg cactcggctg gcttgtcttt tttacgcttg tcggttcagg agaagcaagc 3114001 aaggtcgcat cttatacttt tttgattccg ctcatatcaa tcgtggccag ctccattttc 3114061 ctgcatgaac cgctcaccct tagcctcttg gcagggctgc tgctgattgt cacgagcatc 3114121 tgtctcgtga atacaaaatc aaaagcgcag aaagctgcgg cgattggtat aaacgagaaa 3114181 gctgcacaat aataaaaacc ctcttgccgg atgcggcaag agggtttctt atttactgat 3114241 gcttgcgtcc tttgaccaaa tatgcaactg taatcaaaag gtagatcgcc gcagtaatgc 3114301 cggtaatgac aattgatgtt gtcatgatga ccccgatcag aatggcgagt aatgccacaa 3114361 tcgcaaacca tgtcgtgtac gggaaccatt ttacataata ggccggtgtt tccgtttgct 3114421 gttttctcga ttttaaatga gcgaatccga tgatcagcca aatgaataaa acggtatatc 3114481 ccaatgatcc cattaaataa ttaaatgttt ggcttcctgc gaacagagaa atcaatacgc 3114541 caatatagag agaagaagtg cacatcagaa tcgcaaacat cggtacgttt ttcgatgaaa 3114601 gcttcgagaa gacctttgga agccttccgt cacttgcctg tgtatacaaa atgcgtgatg 3114661 atccgtataa acctgaattc atagaagaaa tgatcgccag caggatgact gcattcatga 3114721 tatgatccgc gcccggaatg cctaccattt taaagaccat cacgaaagga ctttccggaa 3114781 cggaattgac ttggttccat ggaatcaggc tgacgatgat gaaaaacggc agcaggtaaa 3114841 acgcgacaat ccgtgtcagt gtgctgcgga cagctttcgg gacaaccttt tccggatttt 3114901 ttgtctctgc aagcgttaca ccgataattt ctgtaccgcc gtaagagtag atgacgacaa 3114961 gcatcgccgt gatcagccct gtgccgccgt gcgggaaaaa tccgccgtgg tctgtcaggt 3115021 tggaaaatcc ggatgctgta tgatcaccga atgatacaaa taagagcagc aatcccagaa 3115081 taataaagat aataataacg gtaatcttga tcattgccag ccaatattca gtttcggcga 3115141 agattttaac agaaagcaag tttacaatcg tgacgataag agaaattcct aatgccaaca 3115201 cccagatcgg gcagcccggc agccaatatt gaatgaaaat cgcagctaca acagcttcag 3115261 ccgcaatgtt aagcacccac attttccagt agatccagtc caaaaagtaa gcagcgtaat 3115321 ttcccaatac ctgctggaca agatcacgga aggttctggc gttacggttt cgaacagcca 3115381 tttccgccag cccctgcata ataaacagca aaataatccc gccgagcagg tatgcgataa 3115441 tgacagatgg ccctgccaca tcgatcgctg agctgctccc cttaaataaa cctgcgccga 3115501 ttgctccgcc cagcgccatc atcataatat ggcgggacgt catcgtgcgt tttaacgttt 3115561 gattgtcgtt tttcatcctc ttctacctct ccttctcgtt ttcaaaaaca aaaaagcccg 3115621 ccgtctccta cctaatctaa tagataaaga gacgacgagc cttcggctga ccgcggtacc 3115681 actcttgttg attcttcatg aagaatcctg cttttgacct gtaacgaagg ttagccgtta 3115741 aaacataggg aatattcaat ctattccgtt ccgtcttacc actcccgggc gagttcaaag 3115801 aagaatcagg ctgcgtcgca ccaccccgca gctctctgtt ctgatcactt tcttttactg 3115861 ctcccaatct atgtgtttta gttttctgaa aaactcaaat tttatgatct gaatatatta 3115921 acataatata cgtgcttctc ttttaactgt caataacttc agagaaaaaa gaaactgtta 3115981 ttttgtccct tttcgaatgg ctttccaaaa ggattctgac tcgtttccta atgcgtaaac 3116041 tgaaacacct gctattttat attgctttgc cagatggctt ttcgtttgaa cggttttttc 3116101 gttttcatac cacacgacat gtttatgctt ctttttgtca acataagaaa acgtcatcga 3116161 gcctgatttt ttgttgaatg ccggctttgc tttttgtttt ttgatgaggg atttgagctc 3116221 attccattcc cttattgtgc tggtacttcc gtcttttaca tcccagtcat agccgtacgc 3116281 agggattccc atgatgactt tattggcttt gatctttttg actgaaaact gcagagagct 3116341 tttgatccag tttgtgcttg ccactgaccc cggctcaccc caaatgccgt gttcatcgta 3116401 ggtcatgact tgtacgaagt cggcatattt gccgattttc gcataatcat acggccagct 3116461 ccagtcatca tttttatcat cggcgctttt ggccggaacg gataccattg ttttaatatg 3116521 tttcttattc aaagcctgtg agacatattg aatgaagttc gagtatgcag cgcggtcttc 3116581 tggatttact gcttcaaaat cgatattgat tccgtaatat gagtgctttt tggccagtgt 3116641 aattaactga tctgtgaatc gttttttcgc tgttttattg ctcatgaccc gactcgctaa 3116701 atctccgtca aaatcataaa tggcatcatt atagtttgaa atgacagccc atgtcttgat 3116761 ttttttcttt ttcgcatatg tcagctgctt agttggggca tcgccaatga tttgtccgtt 3116821 tttttcaaac gcaaatgtat cggttgcgat ggcattcatg tatgtatgat atttcgtaag 3116881 agaattgtat gaagccgtat ccccagtcgt gtagcctact gtcataccgg ctgccttcgc 3116941 ttctcctttt gtatacataa acagaacaat cgcaatcgcc agtgaaaccg ctatgatcag 3117001 ccattttttc atcgcatttc ctcctgtatc aagtcatact cttctcatcg gccaaaaaat 3117061 tggaagttga agttttttca agcaaaaagc ccggcatatg cctgccgggc ttcctgagtt 3117121 cagcggtcag agacgagaat atatgctgcc tttactggtc catgcacccc cacaactaaa 3117181 tccatttcaa tgtcggctga gttactcggt ccggtaatgt agttgataca tgaaggaaca 3117241 gtgacaccgt tcgcaatgtt ttggcggatg atatcactgg cttgtgtcat tctcggtaca 3117301 atgcttgatt tcggcacgat cgcaatataa gtcgttggca aaaggctgac agagcggccg 3117361 atgtcttttg aggagaagag gacaaccgtc cccgactcag ccaatgtaat ttcgctgaat 3117421 gtaatcccta cattggcttg ctccgctttt ttaatatttt cctcgccttt gtcagcatcc 3117481 cactcccaga ccggcgttcc ttcactcggc cagtccttgg tgagcaggct tttcagtccg 3117541 tattcttcaa agcgggggtc cttcggaatg atgacagggc ctccagaaaa gcggctgact 3117601 tgctcgcgca gggcatcgta aaggccggtt gaatccgttt caatcagctc tgtatggatt 3117661 ttgacacaat ggtttttgag cactgtgact aagtcatccg ctgaataacc ttcaagtgtt 3117721 ttatattgcg gctgatgcgc ccattcaggg actgccacgc ctcctgttct tcgttcacgg 3117781 cccaggctgg atgcgattcg gtttaaaaag ctctcttgat tctgaatggt tcccttcgtc 3117841 atcactgctc ctccttcgtg cgttcacttg tttctctgtc cgcaaaccag tctctgaatc 3117901 tcgatttatg cggtgccggg aagtcgcgaa tctgggtcca atttttaagc gggccgggcc 3117961 ctttcgaaat tttttcgtcc tctgtaaaag gcgtcatggc ggccggcgcc cattttgagc 3118021 ccattttgta aagcgataag gaggatgcgc caagtccgaa tgctttcatt gcaagctttt 3118081 cactgatcgg cgccctgcct tctttttcga cgatattctg acgatgcttg agtagcagct 3118141 catgaagcgg gattttgacc gggcaggctt ctgaacaagc agcgcacagt gaagatgcgt 3118201 acggcagctc cttataatcg tcataaccgc cgagcaacgg tgataaaaca gctccgatcg 3118261 gccccgagta gattgagccg tatgaatgtc cgccgacatg gcggtacaca ggacagacat 3118321 tgatacaggc ggcacagcgg atacattgca gcacagactg gaattccgtt ccaaggatat 3118381 tggatcgtcc attatcaacg atgacaagat ggaattcttc cggaccgtcc acttcacctt 3118441 ccagcttcgg acccgtcaaa gctgtaatat agcttgtcag ccgctgtccg acagcacttc 3118501 tagtcagcat gctgactagc acttcaaatt cagaaaatga cgggacaatc cgctccattc 3118561 ccatgacggt aatttgtgtt ttcggcaagg tgctcacaag ccgtccattt ccttcattgg 3118621 tcacaaggct gacggaaccc gtgtcagcga tggcgaagtt acagccggta atgccgatat 3118681 ccgcttccag aaactttttc cggagaatgg cgcgcgcatg catcaccagc tcttccggtt 3118741 tttctgtatg ttgatagtcc agtctttctt taaacacatc gcgtatctgc tctttatttt 3118801 tatgaagagc gggcgctacg atatgtgacg gcggatcgtg atcatcaatc tgcaaaatat 3118861 actcgccgag atcggtttct acgacttcac agccttcctt ctccagcacc tcattcagat 3118921 tgatttcctc tgtgaccatt gatttagatt tcacaatttt cttcccgttc ttcttttgaa 3118981 tgacatcccg aatataggaa gacgcctctt ccgctgtttt cgcgaaatag acatgtccgc 3119041 ctcttttcgc cacattttcg gcaagctgtc cgagatagaa atcaaggttt tcaaggacat 3119101 gctgcctgat ttcctctgat aatgagcgcc actcctccca gtttcccagt tcttctgctg 3119161 cctctaggcg ccgcgtccgc agacgctcct gtgcacctga aacagcgcct ctcataaatt 3119221 cattatcaat cccctgtgat acccgctctt taaaagcgtc agtaccgatt ttcatcgcca 3119281 tgatcctttc cccctctgaa tccagtttta tctgctgttg agcacttcgg cgatgtgcat 3119341 cactttgaca ttcttatctt ttcggccaag ccgtcccccg atattcatca aacagccgca 3119401 gtcagcaccg atcagcacct ctgctcccgt ttcctccaca cattcgactt tttcatcgac 3119461 catctgctca gaaatctgcg ccatcttgac tgagaacgtt cctccgaatc cgcagcagtt 3119521 atgtttgccc ggaagctctg taaactgcag gcccttcaca tggctcaaca gcttcatcgg 3119581 ctccttccga acacccagca gcctagtcat atggcacgac gtatgtaagg tcgcttttgt 3119641 atgaagggtc gcgccgacat cctctacccc aaggacgttc acaataaaat ctgtcagttc 3119701 atacgtttta tccgccagct ttttcgcttt atcggcccat ttcggatcat cctgaaacag 3119761 gtgcggatac tcccggaaca tcgttgtgca ggaacccgaa ggactgacaa catattcgga 3119821 atcctgaaac gtttcgatca tccgtttcat tgcttttttg gcgtcatgta catagccgct 3119881 gttgtaagcc ggctgtccgc agcaaatctg cccttctgga aaatcaacct cgcacccaag 3119941 ccgctccagc agctcaaccg ttgcttttcc gacatttgtt tgaaacatat caacaagaca 3120001 agtgacaaaa agtgagactt tcatgatgaa cccctctctc atccccaata tatgatcagg 3120061 tcatctgatg acctgagtta aaataactat atgaatatcg tacactattc tgacaatgga 3120121 aggaaagagt tttctaggga tattttcatt tgtggcatat caaaaacact cccgatctcc 3120181 caggagtgca gtatatggtt agatccagcc cttttcctca gcgatgctgg cggcttctgt 3120241 ccgatttttc gcattaagct tttggatgat ttctgagata tagtttcgaa ctgtgccttg 3120301 agataaatag agctccagcg taatgtcttt tgttgtcttg cctaaagccg caagcctcag 3120361 aatttcttgc tctctaacgg ttagcggatt ttcgtctcgc atcatattaa acgtcagctc 3120421 agggctgaag acacgttttc cctttacaca ttttcgaatg gcatcggcca gatcgtcaat 3120481 ttcaccgtct ttcagcagat agccatgtgc accggccttt acggcgcgtt caaaatatcc 3120541 ggggcgggca aaggtggtta aaataatgac cttgctgacg cagccttttt tcattaattc 3120601 ctctgccaca ttcagcccgc ttcgaaccgg catttcaatg tccataatgc atacatccgg 3120661 ctccagcttc aaaatagcat gtagcgcctc ttccccgttt aatgcttgtc cgatgactgt 3120721 catatcctct tctaaatcaa gcaaagatcc caaagcgcct aaaagcattc gctggtcctc 3120781 agcaataaac agacgaatca ttcttttcgt cctccaatca ttctgctttt ttaataagcg 3120841 gaatcgtcag tgccacaacc gttccgttat ggtctgaaac cgttaatccc ccttcaatga 3120901 gcatgagccg ttcttccatt ccccacaggc cattcccaaa cattttctcc ttcggcgctc 3120961 cctttccgtc atcccgtatt acgatcctca ttttgtcagc aaattgagaa atggtgatgg 3121021 cacagtgggt tgctttgctg tgcttgataa tgttagtcac ggcttcccgc atacacatac 3121081 tgataatatt ttgagtgacg ggagatatca ctgaaaagtc gtcggctcct tcgtattgaa 3121141 aggtaatgtt ccccgctctt aatatgtgct gaatgtttac gagctcctct gttatcgtga 3121201 ccgttctcat atcagaaacc agctctcgaa cttgcttgag tgcggagcgt gaactggttt 3121261 ccatttcttt tgcctcaagc ttggtccgtt ctggatcaga tgcagccagc cgctgaatga 3121321 gctggctttt taatgtaagc agcgacaggg tgtggccaag agtatcgtga agatcacggg 3121381 cgattcgaac acgttcctcc cttttagaga gttcttttat ctgttcgttg gcttgtgcaa 3121441 gcttagcttc aagctcaatc ctccgaaaca tagaacgaat tccgaatgga gaaatgagca 3121501 taatgacgag aaacgggaga acagaaaaaa gctcccgaag cgagaccgaa ttcgcgataa 3121561 attggtatag gcatggaaaa agcagtataa agattaaagc gcagaacgca cggttaaaat 3121621 tcgttttctc tttgtaataa ccaacaaagt ttgccggaaa aaaacctaag tatatatagg 3121681 tgatattgta aaacacacta tacatcaaaa taaccgccat ttgcacgata agccaatatg 3121741 taaacgaagc tttgcccacg ctgcagaata actggcgata tgccgctaca aaaaggagca 3121801 gcataccata tccgatcccc tgtttgaccc ctgattcttt taataaagag aggaacggca 3121861 taatcgtata caccagaaag atataaggga aaaacccgaa ttccttcggg aaaatagata 3121921 ttgccttttt catgtattac accgcttctt gttttcttct tatatattta gatagtagca 3121981 tgaagagcat catataagcg attaatatca gaatattttt ccaagtcgga ctcccacccc 3122041 ggacaagttc ccacgctccg ctcccgaaat gataagacgg aagccactgg ccaatgctct 3122101 gcatcatgtc aggcatgacc tcaaacggca tccacatccc tccgcctaaa gccagcagca 3122161 tataaagcac attactgatt ccggccgctg tttctacttt tctcatgagg ccgattagtg 3122221 tgcctaatgc taaaaaaggc aatgcgccaa acaaaatcca cagtccgctc atcatccatt 3122281 caaacggtga caaggcaata tcattgatga ttgcgccgaa cagaaatatg acggtaattg 3122341 ataaaacgtg aatgacactt tggccgatca tctgagctga taaatagata tgatccggaa 3122401 gaggcgtaag gcggataaag gcggcccagc cttgtgaccg ttcttgtacc attcggatgc 3122461 caagcgtcat gatagaggaa cccatcacgc tgaagactgt catcgacatc aggtaatggg 3122521 cttcccatgc acgttgatca gggacgttgg tattcactac atttgtaaag aaataataaa 3122581 aggcaatcgg catgatcaga gaccaaagca caaagtactt gttcctaagc acccttttca 3122641 tttcagcgat gctttgcttt tgcagcacgt tcactcacat cgcctccctg ttgccgtcag 3122701 ccagctggcg aaatgcctca tcgagcgttg cttgctcaat tcgaatatcc cgtgcatgta 3122761 tgttttcttg aaagatcagc gccaacactt tgtctgtatt tgatgtctgg atgatggttc 3122821 tctcatgctc gtggatcact ctctcgactt ccgggtgaca agacagcctt tccaatgatt 3122881 cacttgaatg aagcgtaaag gaaacagact gtttttgaat tcttgagcgg atttgcattg 3122941 gtgagccgtc tgcaacaagc tgtccttcag taaaaaatag gattcgctgt gcggcatcat 3123001 ctgcttcctg taaataatga gttgaaaaaa taatcgtttt tccttggtcc gacagtccgt 3123061 gaatggtctg ccagaatcgg tgtcttgatg aagtgtccat gccgactgtc ggttcatcaa 3123121 gtataagcag ctccgggttc ccggcaagag ccaaagcaaa gctcaaacgg cgtttttgtc 3123181 cgccggataa tttttctgct cttgttttca aatcttcttt ggtgagtgct gttaacgaaa 3123241 cgagttcttt catggacaat ggattcggat aatagctccg gaagagttca aggatttcat 3123301 ccaccttaag gcccggcatg acacttactt cctgaagcat tacacctatt ttttcacgaa 3123361 cctgttgatc atcgggaacc cggttaaata gtttgatttc tccctcactc ggtttcagca 3123421 atcctaatat catcgagacg acggtcgtct tccctgcccc atttggcccg agaatggctg 3123481 caatttctcc tttttcaata ctgaagctga tgttgtttac agcggttttt cgctggaaat 3123541 gttttgtcac gttgcttact gttactgctt ctttcatcac atgagcacct cctgatcgtt 3123601 tacattgatt gtaaaatgac ggagaagacg atgttagtat ggggtgtcat gatgatggag 3123661 tgacaaatgt catttttttc tcaccccggt gtctaggcaa tcctcctcct gcatcttcca 3123721 attcatccat cttttctatc tcccatgtcc tctttctttt aaactgctgt gacattcata 3123781 gaaagataca ctcttcaaac catccgagtg ttatgataga aatattgaac tttatattac 3123841 tttccggctg aaaggagcca atcatgaacg aagcgatttt gtctagaaat catgtgaagg 3123901 tgaaaggcag cggcaaagca tctatcatgt tcgcacctgg ttttggatgc gatcaaagcg 3123961 tgtggaatgc cgtggcacct gcctttgaag aagatcatcg ggtgatttta tttgattacg 3124021 tcggttcggg acattcagat ttgcgcgcat atgacctgaa tcgttaccag acacttgacg 3124081 gctatgccca ggatgttctt gatgtttgtg aagctttaga tctgaaggaa accgtgtttg 3124141 tgggtcactc cgtcggggcc ttgattggga tgcttgcatc catccgccgc ccggagcttt 3124201 tttcccatct ggtgatggtg gggccttctc cttgctattt gaatgatccg cctgagtatt 3124261 acggaggatt tgaagaggag cagctccttg gcttgctgga gatgatggag aaaaattata 3124321 tcggctgggc gactgtattt gcggcaaccg ttctgaatca gccagatcgg cctgaaatta 3124381 aggaagagct tgaaagccgt ttttgttcta ctgatcctgt cattgcccgc caattcgcga 3124441 aagcggcgtt tttttctgat caccgagagg atctttcgaa ggtaacggtt ccctctctta 3124501 ttctccaatg tgcagatgat atcatcgcac ctgcaacagt aggtaagtat atgcatcagc 3124561 atctgcctta tagcagtctg aaacaaatgg aggctcgcgg acattgccct catatgagcc 3124621 atccagatga gacgatacag ctgatcggcg attatttaaa agcacacgtg tgatatagga 3124681 acgaaaggga tagaggtgac cctcttagat ggacaaacaa ttgaatgatg caccatgcgg 3124741 tttcctcgct ttgtcagaag aggggtcgat catagctgcc aaccgcaccc ttatcaagat 3124801 tctggattat gaaccggagc aggttatcgg ccagcacatg aatatgatgt tgaccattcc 3124861 cgcgcagctt ttctgccagc tttatttttt tccgcttttg aaattggagc atcacatcga 3124921 agaaatatac atttccctga aagcaagaga tggagaagaa attcccgtcc ttatcaatgc 3124981 tattgcgaga cacgatagcg gggcttctgt ctttgattgt gttctgattc caatgcgaaa 3125041 gcgaaatgaa tatgaaaatg agctgctgat agccagaaat gaggctcagg aagctttgct 3125101 tgccaaacag aaagccaatg cggagttaga aattgccttg gaaacgctga aagcaaaaca 3125161 agaagaactt cttgagatca ataaacaaaa tcaacaattt aaattaaaca ccaaaagaga 3125221 gcttgaactc gccagaaaga tccagaaaaa ctcgttgact gaaccgattg taaacgatca 3125281 ggttcagatt gactcttatt acaacgcatc gagtgaattg tcaggtgatc tttacggata 3125341 ttatcaaatc gatgaacacc gttacggcat tattatcctt gatgtgatgg ggcacggaat 3125401 ttcatctgca ttgattacga tgtctcttca tcctttgttc cagcgccaga tcacgcaagg 3125461 tctcagcccc gttaaagtta tgaaggaatt ggaccggcac cttcacagct tgtttcaaaa 3125521 tgatgaggaa gcaagacatt attgcactgc tatttatctc gagattgata tagcacggca 3125581 aagaattgat tatgtcaacg cagggcatcc gccggcactt tggcaggacg atagcggaac 3125641 tcaacatctg cttcacgcga cctcgcctcc gatcgggatg tttgaagact tagagtttca 3125701 gtcaagcagc ctttcataca cggaggacgg aagattgctt ctgtatacgg atggcgtgat 3125761 ggatcctacg gcttcatgtt atttatttga tttactaaag gatcatcctg attcgccaat 3125821 cgctgacctg aaggagaaaa tccttacatc actgcagcat caaaaggaag ctcatcataa 3125881 gagtgatgac gaatgtttta tattagttga tgtaaaataa aatgatccat gagacataac 3125941 aatgatttgt tacatctcat ggattttttt gtttcagcgt ttctttggaa tatgtcctga 3126001 ctccgcatat tgaaacacct gcaaggaagg cagcgggtgt ccattaaaat caaataaagc 3126061 ttgattatct acagcacttc ccccatacca cttcccggcg tcttcagggt cgtattcagc 3126121 agcatagctg gacgcccacc ctgacccgta tgtttcccat aacactttgt ttttctctat 3126181 ctgtgtcttc ggcccgactg gaatccacgc cggctcccag tagaaaacac caagtcctgc 3126241 tttgcccgta ttcgccactg cctccattac atctcttact gcagttgcct ggccttgaac 3126301 agaaattgga tatggcaacg tctgcccgct ttttggtgct gtatttccat gcccatcgcc 3126361 atcctcagcg gtataggtgt acgatgtctc cgccaccatg acttttttgc cgtacgtatt 3126421 ggcaacagcc ttcagcacgg aggtcaaatt ttgtaatgtg ccatgccaga aaggataata 3126481 ggagctagca aacacatcat aatccacttt gtttttgctg agtgtttctg caataaatga 3126541 ataccttcca gccgtttcag gattggtaaa atgcagggcg accaaaatat ttgaatttgt 3126601 ctccctgacc gctcggcttc cttcattaaa taattggcac atcttcgtcc aatcagtctc 3126661 accggcaaat cctcctgttg tttcatttcc gacctgaacc atgccgatgt caacgccttc 3126721 cttgatcatc ttttgcaggc tttgtttcgt atactcatag agctttgctt tttttgcttc 3126781 aaagctgaga ttcgcccagg ctttgggcac cttttgtttc gctggatcgg cccagaaatc 3126841 agagtagtga aagtcggcca gcaccttcat tccgttcgct gtcgctcttt ttccgatttc 3126901 gatggctttt tgaacatcat tgtttccccc gccatacccg ttgccatttg aatcatacgg 3126961 gtgattccag atgcggacgc gaacatagtt gaccccagcc tgttttaaag ttgtaaagat 3127021 atcctggcgt tttccgtttg tattgtaaaa ggtgacaccg ctgttttcca aagcaataac 3127081 gctggataca tctgcccctt tgataaaatc cttgttcatc ccctctactt ttttaacaaa 3127141 aagatcctct gcccgaagct ctgacacgtg cttctccttc tcaatggcag cggcatatcc 3127201 tgttgaacta catgcactcc acacgatggc agccgcaaag aacattttca ctttgctttt 3127261 catgatttca tccccccaag acttagcaag cgttttcatt ctatagaaaa aagaatccgc 3127321 ccatatcgag cggagcatca gcctaatgtg tgtttacgac aattctcact tcatactttt 3127381 ccatcgtcag gtcgcctgac aatatgtctc ctgtcattat gtccttcaca ctctgatcaa 3127441 acgtgaccag ctgtttttct tccgtgaaat tcatgacaaa aatataatca ttgtcctgat 3127501 cctgcctcgc ttgtacggag acgccttttc cgtgccgaac cggaaaaact ggagagagag 3127561 acaggtctgt gatcagaccc tcatagaaat cacgctgaaa ttgatcctcc aaacgcgcgc 3127621 cgataaaata cgccttgccc tgctgatact catggcttgt gaccgctggc gtgcgcgcat 3127681 aaaaatcttc ttgatacacc gcttccactg aagctgtctt tacatcaatc acggttgcat 3127741 aatccttcat ttcatatatt tggctgcggt agctgacagc gtttcgatcc ttcggataca 3127801 gggtgtccgt ttcaagaggc tcaactccaa atatagcttg aagatccgga tgccatccgc 3127861 ctgtgtatgt taagtcatgc tcattcacaa ccccgctgat atacgtcatg actaaggtgc 3127921 cgccgtcagc cgtaaacgct tttaaacggg aaacggtgtc ctcgctgatt aaatacagca 3127981 tcgggacgat cagcagttta tatggtgaaa agtcttgttc tttcgtgatg acgtcgacag 3128041 ggatatcgtg ttcccagaat gtgcggtaat gctgctgaag cgtttgcgga taacgttttg 3128101 tcgccttcgc aaacccctga gcatcctcga gcgcccaatg attttcccag tcatataaaa 3128161 tcgcggtttg agccggcctc ttcgttccga caacttcgga cagccgttcc aatgtctcgc 3128221 ctaccttggc cacttcttga aagacgcggt tcttcgggct attgtcatga tccacaaccg 3128281 ctccgtgtaa tttttctgat gacccccgtg atttgcggta ttggaaatag agaacgctgt 3128341 ccgagccgtg ggcaatcatt tgcatggatg acagcagatt catgcccggg cgctttgcct 3128401 tgttgacgtt atgccaattg accgcgcttg gcgtacactc cattaataag aagggctgct 3128461 gcttcaagct tcggtacaga tcattgataa agccgacctt catcgccaaa tcagctgtgc 3128521 tttcccagtc attgtgccag acaggataag cgtcccagct gatggcatcg acatgctttg 3128581 caaatttgct gtagtcgagg ccctgatacg ggatcaaatc cggtgtgtca gccataaaat 3128641 tcgttgtgat agggatatca ggcgtcaatt ctttcagcgg aatgatttca ttttcataaa 3128701 acgaaatcgt ttgatcggtg acgaaccggc gccaatctaa attcaggcca tgcaagccat 3128761 tttcaccgat cggcgaaggg ctttcaattt gtgaccagtc attgaacgta tggctccaaa 3128821 aaggggtcca ccacgcatgg ttcaatgtct tgaggctgtt gtcatatttc gatttcagcc 3128881 actcccggaa agcatgctgg cataaatcac agtggcaatc tcccccgtat tcgtttgaaa 3128941 tgtgccacat taacagcgcc gggtgatgtc cgtatcgttc tgctaataag cggttgatgt 3129001 gccgtgtttt ttctcggtag actttagatg tgaggcagtg gttgtgcctt ccgccgtgca 3129061 gctgtttgac gcgggaggca ttgacgcgca aaacttccgg ataggtttgc gacagccagg 3129121 ccggacgggc tccgctcggc gttgctaata tgacccggcc gcctatactg tgaatccgct 3129181 caaaaatatc atccagccat tcaaattgat atacgccctc ctccggctca agtgcgctcc 3129241 atgcaaaaat gccgacagaa aacgtattcg tatgagaaag cttcatcagt ttgatatcgt 3129301 cagctaaaat atcgggccga tccagccact gatcggggtt gtagtctccc ccatggagca 3129361 taaattttgc ttttgttacg tgcgtttttt caagctttga catcacattc tcctccttgt 3129421 tctcttagcc cttcgttccg cctgcggtta atccggacac aaaattcttt tgcagcataa 3129481 taaagatgac ggcaaccggt atgctgataa gcagggctcc ggccgcaaat gtcgtatagc 3129541 tggcccccat gacatcattc actaaattga atagaccgac gggcaatgta tatgattcag 3129601 gcgttctcaa tatggttgag gacagcacaa aatctccgag cggaccggta aagccgttca 3129661 tggccacgac tgccgccatc ggttttgata atggcagaat gatctggaag aagattctgg 3129721 tgctgctggc tccgtcaatc ttggcgcttt cgtctaaatc catcggaatg gaatccatgt 3129781 accctttcat caaatacgta ttcatcggga tcaggccgcc gatataaagc aagattagca 3129841 gccagtggct attgatcatt cccaagattt gcgccagcac aaacaaggca attaaagctg 3129901 aaaactgagg aatcatctgc agcaataaaa agagcgttaa agcgtatttc ctccctttaa 3129961 accgaaagcg cgaaaacgca taggccgtaa acgtcacaca gagcaaagac cctgccattg 3130021 taaacaggct gatcttcata gagttgacat accactgcac atattgaagg ctttccttgc 3130081 ccgcaaataa ttccttgtaa tgatcgaatg tcggatgctt cggaatgatg gatgtactga 3130141 ttaagctgtt gccgggatta aagcttgcgc ctgccgtcca aaggagagga taaacaatga 3130201 tgaccgccat aaaggctagc aacaagtaag agaaaaggag acggatatat cttctgactt 3130261 tcatatctgc cagcatacct tatgcctcct ctttaaaaga ctttgtctgt ctgaactgcc 3130321 acaatgcgat ggagataaca aatacagata ataaaatggt taaagccgca gcaagtgaat 3130381 attggctgga ctgcattgtc aatttataaa tccatgaaac gaggatatct gtcccgccgg 3130441 ctgttgatcc ggttacagcc ggacctccgc cattgaatag atagataata ttaaagttat 3130501 taaagttaaa cgtaaactga gtaatgataa tcggagccat tgcaatgaac accatcggaa 3130561 gcgtgatgta tctcagcttt gaaaagacag aagcgccatc aatcgtagct gcttcataca 3130621 gatcgtccgg gatggattgc aatacgcctg ttgagacgag aaagatgtac ggaaatccga 3130681 gccagccctg catgagaatc aatgcaagcc tcgaccaatt ggcatctgtc atccacggaa 3130741 gcggatctat cccgaagaaa gccaagatgt cgtgattcat cgcaccgaag ctatcattaa 3130801 acagtcccgc aaaaattaaa atcgtcacaa aaccgggaac ggcccatggc aaaatcagaa 3130861 tcgtccgaaa aaaacgttta aaccgaaggt ctttctggtt aacaatgatc gcgagaaaaa 3130921 tccccaaggt gacttgcagt gtggatgcag caagtgtcca aaccaccgtc caagccagta 3130981 catcaaaaaa agtcgacctc caaatatcaa ctgtgaaaat atttgcgaac gtttgaaaac 3131041 cgacccaatc aattaatttt gcaggaggag aatgatacaa atcatagttt gtaaacgcta 3131101 atgcaaagct gaataagata ggaaagatca cggcgaaaat taaaataaac aaagatgggc 3131161 cgctgacgac ataaggatag ccctcagaaa tgatatgctg gtattgttcc tttaaggaac 3131221 ttaatggctt attttcatca cgctgttttc cgctttggaa cgcatcgcga agatttacat 3131281 aatacaccgc aaggccaaag caggtcacga tgacagcaat aatcccttcc gccagcagaa 3131341 aaacggaatt atcccgcggc acttctgttc ccagtgtaaa gattccccaa aaccccatat 3131401 tgagcagatc tccaaagacc gcaaaaaacg atgcgcctaa gaaaagaaag acaatacctt 3131461 ttatccattg cttgttataa aattgcccga gtcccggaat gatagaaagc aacaaagcga 3131521 cttgacgatg ctgcaccgtt ttcacctctc ttacaataca aatctagctt tctctttatt 3131581 ttccgctgtg ctttgcctta atttgtcctt tggccgtttc agctgcttga tccaatgctt 3131641 gtttcggatc tgccttccct gttgcaaccg tctgtaatgc tgaatcagcc ggcgtccata 3131701 tttcattcat ttccggaata tttggtgttg gctctgagaa acgggattgt tcagtaacag 3131761 cccgtgccgc ctcgcttttc ataatagccg ggtcattggc tagggatttc acagcaggaa 3131821 cttctttcgt ttcttcatat cgtgttttag aatttttttc atttgccagg aaaacggcta 3131881 attcttgcgc cagctcttca ttctttgaaa atgcactgac gttgtagctt ttgacgccga 3131941 taaaggagct catgtttttc ccattttcca gcttcggcag tttcgtaatg ccataattga 3132001 ttcctgcatt cgaaaaggct tctacattcc atggaccaga aataattgcg gcggcttttc 3132061 cttctgtgaa cagcgattcc aacacgttaa tcccttgttc tccaataatg ccagccggga 3132121 acaggccatc tttgtaaaac ttctgaatca gcgccgcacc tttgacagct ccttcattat 3132181 tgattccaat gtctgacggg ttatagctcc catctttggc ctttccaaaa atgtatccgc 3132241 catatccgct catcacactt tctgcataat aaatttgatc gaatagggct aaaaagccaa 3132301 atttgctgcc gtcagcagtc tttttggaat agtcgtacca ctcttccagc gttttgggca 3132361 attccttttc tgtgatgaga tctttgttgt aaaaaagcac agtcgtttcg accgcttttg 3132421 gcagtccata aagcttttga tctaccattt gagactgaat ggaagcgtca gtataaagtg 3132481 attgaacgtc ttttttgaca tgtaattcct tgagtaatcc ttccgtgaca gcggttccga 3132541 tttggtcccc tggcattgtt aacacgtcag ggcctgtgcc ggccggtcca tccattcgca 3132601 aatcttcaat ctgcttggca tacggttttt caacgacttt gaccttcaca tcatgctctt 3132661 tttcaaatgc agccacagcg tctttaatgc cgttgctctt ttctttatcc tcccatacaa 3132721 caagctctga cccttttgaa ctcgatttgg cgctgctgct ttcctttggg ccgcaagccg 3132781 ccaaggataa actgacagct gcgcagagca tgaatacgga acactttttt gccattttca 3132841 ttgattgtca ccctttcggt aggaatgaaa gcgctttaaa gataatatag catgcctgag 3132901 aaaatgtgta aacaaactat ttacttcata gagtaaattt ttttacctaa ataaaaaatg 3132961 acttagtgtc ctaagtcatc cttaattcat actcttcctg acgattaatt ctgcgcccac 3133021 atataatgtt tttaccgttc ttctcttgtc ctgcacttgt tcaagcagta attgaacagc 3133081 gtttttacat aattcatgta tatcaatatg aaacgtcgtc agaggaggcg agacatactt 3133141 cgcgaagctg atgttgttga tactcacaat gcttaccctg tttggtatgg caattccttt 3133201 ttcgttcagg gcttgcagac agcccactgc aatcgggtcc gctgcaatca taaaagcagt 3133261 cggaagctga tcgcctaatg tgtcgatcgc tgctgacatc aggcggtagc cgttttctac 3133321 agagaatccg cgatgacaga aaatatagcg ctcgtccagc atggcttttt ccctcatata 3133381 ggatctgaag gtttgttcac ggatgtccat ttcatcctga ttggtattcg gatttttgta 3133441 tgtgccgccg ataaaaccga tgctcttatg ccccttctca gtcaggatgt ttaccgtctt 3133501 ccttgtcatt tgtgccaaat cgggccttac cgagtcaaaa tgatcgggat caggagttga 3133561 atcgatgaac acgccgtttt cagtgagatt tctgaggaaa gccagctctt catctgaaaa 3133621 tgtgccgacg gcaataaacc cttccgtatg ttcaggaatg ctctcgattc catccgctat 3133681 tttataagtg gtcatatcga cattgaatgc tttcgccagt ttctctactt ctaatctcat 3133741 cgttttaaaa tagacatctt ctaattcttc tttatctgtc agccaatata aaaacgcaat 3133801 atgtttcacc agcggcctta ctgttttttt gcggtaattg agcttttccg ccgcttcata 3133861 gattttctcc cgtgtctcat caggaacaga aaggctttca tcgttattta aaacgcggga 3133921 aacggttgag attgaaaatc ccgcttcctg cgcgatatct ttaattgtcg ccattgtatc 3133981 tgcctccatt attcagctcg cattgtttta gtaaaatatt ttactttctt tttcacaaat 3134041 gtcaagtgca caaagccctc tggctgccat gtaaaaagac tgaaccattt gcggctcagt 3134101 ctcagttgtt cgtatcattc ggaaccggcg gaattgcccg ggaaatgagt tggttattgc 3134161 acattttcct cgaaatatcc cgaaagcaca tcttccacat tcgtcaaatg cgccagcatg 3134221 gcggcttccg cctgtgcacc gttcccggca gccacagcat tgtaaatccg ttcgtgctcc 3134281 tcatacagcc gctgaacgga ggtcttcttg gaaaacagcc agattttcct cgtttccctc 3134341 attgtttcca gcagcaatga tgacacgtga ttcatcaagt gtttaagaag ttcattttga 3134401 gaagcgtccg caagcgcaag atgaaatgca aagtctgctt tctctcccag ctccccgtcc 3134461 gcttcaatgc tgcccatttc ctttagtgca tcctgaattc tttcgagatc tgcttctgtc 3134521 cttttttcag ccgctagtga agccacgccg atttcaagca gttttctgac ctcgagcagc 3134581 tgcttgacgt cctctttttt catcagaagg gcggctgaga gcggctgaga aatttgattg 3134641 agctcaaatt ccttcagata cgtgccttct ccctgtttca tttcgacaag ccccatcgct 3134701 tttagcgcag aaagtgcttc gcgaaccgct gaacggctga cttgaaagct ctcagcaagc 3134761 gcctgaacag agtccagttt atcccccggc ttcaattcgc catttttgat catatctaat 3134821 agggcatccg ctacttcttc atatattttt ttgttttaat ctgtttatat ttcaatgcaa 3134881 ttcaccccgt aacttgtagg tctggctgtt tacgatctat tatactctgt tttgtgggcc 3134941 gccaaaagat tttgactatt ttgtcaaaaa gtcttgtact ttgatttttt tcaaaatata 3135001 atgctaggta actggtctta ttacccagtc atcagatgat catatcatct atagaaaccg 3135061 cttacatatg gcgccagttt atgtttcaag gaggggtttg ggatgcaatg gacacaggca 3135121 tatacgccta tagggggaaa tttgctatta tcagcgcttg ccgcacttgt accgattatt 3135181 ttcttttttt gggcactcgc gattaaacgg atgaaggggt atacagcagg cttggccaca 3135241 ttggggatcg cccttatcat tgctgtattg gtttatcgta tgccggcgga aaaagcgctg 3135301 atgtccgcga cacaaggagc cgtatacgga ttgttgccga tcggctggat cattgtgacg 3135361 tctgtttttt tgtataaaat cactgtgaaa acgggacagt ttgatatcat tcgcagctct 3135421 gttctctcga ttactgatga ccgacggctt caagctctct tgatcgcttt ttcattcggg 3135481 gcttttttag aaggggcagc aggcttcgga gcgccggtcg ccatttctgc cgcgctgctg 3135541 gtcggtctcg gctttaatcc tctttatgct gcggggatct gtttgatcgc caatacggcg 3135601 ccggttgcct ttggggcaat tgggattcca attacagccg tagaagggcc gacagggatt 3135661 ccggcgatgg agatttcgca aatggttggg cggcagctgc cgtttttatc cgtatttatt 3135721 cctctttatt taatcatcat catgagcggg ttcaggaaag ccttggagat ctggccggcg 3135781 attctcgtat ccggtgtttc ctttgctgtt gttcaatatc tcagttccaa ttttttaggg 3135841 cctgagctgc ccgatgtttt gtcagctctt gtttcaatgg ctgcgcttgc tgtgtttttg 3135901 aaatggtgga agccgaaaac aacattccgg tttgccggtg aacaagagtc ggccgcctca 3135961 attgaaacgg cgcgcacaaa tccggcggcg cctgcataca gaggcggaca gatttttaag 3136021 gcttggtcgc catttctgct gctgacggcg atgatttccg tatggggcat tccatctgtc 3136081 aaatccgcgc tgaccgggca ttatgaaggc tctgcggtgt tcttgaagtg gctgaatgct 3136141 gttggagaaa aactgacttt ttcccccggt gtgccttttt tgaacaatca gattgtcaat 3136201 gctgacggta cgccgattga agcggtttac aagttggagg tgcttggttc ggccggcacc 3136261 gcgatattga ttgccgcagt gctgtcaaaa ttcatcacgg cgatttcgtg gaaagactgg 3136321 ggaaccgttt ttaaagaaac agtccaggaa ttgaagcttc cgattttgac cattgcttct 3136381 gtcgttggtt ttgcctatgt caccaactcc tcgggaatga gcacgacact cgggatgaca 3136441 ctcgcgctga caggttcgat gtttaccttc ttttcgcccg ttctcggctg gctcggcgtc 3136501 ttcattaccg gctcggatac ttctgccaac ctgctgttcg gcaacctgca gaaagtcacc 3136561 gcattatcag tcggcatgga ccccgttctg tctgtggccg ccaactcttc aggcggtgtc 3136621 acaggaaaaa tgatttcacc gcagtcgata gcggtggcgt gcgccgcggt aggactcgcc 3136681 ggaaaggagt cagatctttt ccgctttacc attaaacaca gtctgttttt gctgctgctc 3136741 gtctgtatca tcaccttttt gcagcatcac gtattcagct ggatgattcc ttaaaaaaat 3136801 cctcccgtct agggaggatt ttatttatat cgctttctcg ctgccgatga cggaatattc 3136861 atttgatcgc gatattttgc cacggtgcgt ctcgagattt ggatgccgtg ttgttcatac 3136921 agcaaatcga caagcttttg gtctgaaagc ggttttgttt tgtcctcttg attgatcagg 3136981 ttttccagat gcgttttgac tgcataattc gacgcatctc catcacctga agcctcggct 3137041 tttgctgaga aaaagagttt catctcaaac agcccgtaag gcgtttgtat tgttttccct 3137101 ttaatggccc ggctcacagt tgattcatga aggcttagac agtctgccac ctctctgaga 3137161 gtcagcggct tcattgcgct tcgccctttc agaaagaaat ccttttggcg tgtgatcagt 3137221 tcattgataa ttctcgtgat tgtctgtttt cgctgccgca gcgcgcggct cagccagcgc 3137281 cactcctgat atttcgcaga taaataggag acagtatcct gacaggagcc ggatgataaa 3137341 agcgttctgt actgcggatg cagatcgatc tcgggaaacg agcgggtatt cagttccgct 3137401 gcgatgtgcc cattttttac ggtgataaaa atgtcaggct caatatacac atcttgctct 3137461 ggccgggcaa acagaaggcc aggtctagga tgaagagccg cgatatcatc tgagatatct 3137521 tgaatggtat gaagcggaat tcccgtctct actgaaagcg ttttccattt tttttgcgca 3137581 aaagcatcaa aatgagctga aaccagcatt tccgcttgtt catttctgtt cggcagccgc 3137641 tgtaattgaa gaaggatgca ttcctgcaaa gatctcgcgc cgattccagc cggttctaac 3137701 gactggagtt ttgccaaaac agcctccgct tccttggccg atacagataa tcgccgtgct 3137761 gcctcctcta tatcttcttc caagtacccg tttgaatcaa gcgaatgaat cagataatta 3137821 aaaatctttt tttcagtgtt tgtcagattc atatcgagtg actgctgttt taacgcatcc 3137881 tgcaatgttt tttgcggatt acttaattga aggcccgctt cctgtgcatt catcctgttt 3137941 ttgtttgttt tatggtaaga tagtggcggt gtgtctgttt cctttcgttc aataagaggg 3138001 ttttccagtg agagctcatc aatgtactcg gcgagttctg ccgaatgata gccaagcagc 3138061 gtgatggcct gcctgagctc ctgtgtcagt tgaggcttta atacttgtac ttgctgaagt 3138121 ttcatatcca tcttgctcac tcccctttct tcattgtaca tgattgagat cacaccgtat 3138181 acatttatga aaaaggagct gccaaagaaa tgtctgaact tttttccgtc ccttatttta 3138241 ttgagaattt aaaacagcat attgaaatga atcagtctga ggataaaatc cacgcgatga 3138301 acagctacta ccgttccgtc gtctcaacac tagtgcagga ccagctgacg aaaaacgcag 3138361 ttgtcctgaa acggattcag catttagatg aagcatacaa caaagtcaaa cgtggagaat 3138421 caaaataaac cttccgctca catgtgagca ggaaggtttt ccttctttga ggcgtgctgg 3138481 atgagacggg tgcttggcac gccttccatc caggtatgaa agtaattggc gtttttcccg 3138541 taggaattat caatgaccgt gttttctttt tgaagaagag aagacaggat gtggccgtgc 3138601 agccttgatg tttccaccga ttcgtaacgg ctgaaaaacc gaatcgcttt ttggacgata 3138661 taatccgagt atttttccca tatatacgca atgggcaaag ggttgcctgc ttttttattc 3138721 aagacgttca gcgtttggag aaaagcaatc gtccggcggt ctgaagctga cagcaccgtg 3138781 cgccagtcgt agctttccgc ttctgcgtgt tcctgaagcg cctggtttgc ttcatgatct 3138841 gttcggataa atctcagctt ttgattggac ggctgctgcg tgggaatgac gggaaacagc 3138901 tgatgagcca tatcaggcag aagctgaatg tgatttgttg taaaataggc ctgtgccgta 3138961 gcataggagg ctttttccct tgtcatgatg tgaaggttcg catgcttaga aaatatctct 3139021 gccgtccgct tgaggttgtc tttgttttga aaataaatcg attgcggcag gatcacaatt 3139081 ttgtggttcg gataggtttg gacgattttc tctctaaagc cttgataata cggatacaga 3139141 tccccgaagt ttccgcctcc ctggcagacg atgatgagat tcggatcaag ctttcgcccg 3139201 attgggaaat tgtctggatt ccagcgtttt ctgacccgaa tcccgtgttc tttaaagaag 3139261 gcttctgttc ctttcataat aaataaatcc cctacattcc catatagagg atagtcagca 3139321 tatataatct ctgattgttt cggaatgacg tcgagcagcc cggacagttt ctgtttcagg 3139381 ctgatcatcg aatgcttgct gtccatttct tcacctcgac agtatggaat aagtgcagta 3139441 gcacttcaat gacccggcct tgctcatctt ctgtcatatt ggaccccgat gggagacaga 3139501 ttcctcgctt gaacaaatct tcgcatacgc ttcctgtatc ttcatgagaa taaaataaag 3139561 ccggatcgaa cagcggctgg gtatggagcg gcttccacag cggacgggct tcaatgtttt 3139621 cttcagcaag acgttgaact atgtcatatg ggctgagccc gttatcaagt gtgagcgtgg 3139681 tgagccagcg attggatacg cctgctgcgt actctggcat aaagcggacg ccgtctaagt 3139741 gaccgagcgc atttttgtat ctcgtgaaaa tggtccttct tttctccact cgctcatcca 3139801 gcacctcaag ctgggcaatg ccgacgccgg ctaagatatt gctcagcctg taattatgtc 3139861 caatttcact gtgctgataa tgaacagccg gctctcgtgc ctgcgaagcg agaaatcttg 3139921 ctttttcaat tgcggcttca tcatttgaaa cgagcatccc tccccctgat gtggtgatga 3139981 ttttgttccc gttaaatgaa aaaatgccga agcgcccgaa tgttccgctt tgcttccctt 3140041 tatagactgt gccgagagat tcggctgcgt cctcaatgac aggaactccg tatgcatcac 3140101 acaggcttac gatttcatcc attttcgcgc tctgcccata tagattgacg gcaattaccg 3140161 cttttggcag tgttccgttt cttttcgctt cctccaatgc tctttcaagg gctgtcggcg 3140221 acatattcca cgtatcaggc tcagaatcaa taaagacggg caccgctttt tcatatagaa 3140281 tcggattggc ggttgctaca aatgtgaagg actggcaaaa cacgctgtca ccttctttta 3140341 cctcaagcaa acgcagcgcg agatgaatcg ccgccgttcc tgagccgacc gcagctgctg 3140401 cttttacacc gactcgttct gccagctgtt cttcaaatga attcacgagc ggcccaagcg 3140461 gcgcaatcca gtttgagcga aaggcttctg aaatatagtg ctgctccctg ccgctcatat 3140521 gagggggaga taagtagatt tttttatgca tagaatcatc ctttgtttga tgtttgaatg 3140581 gaagaaatga tgcgtgccgg agcaccggcc gccgttaccc tgtccggtat ggaacggatc 3140641 accgcggagc cggctccgac aatgctccaa gccccgatta tgatctgcgg tatgacggat 3140701 gcaccggttc cgacgtgagc gccttcctga acggaaaccg ctcctgacag cgtggcacgc 3140761 ggggacagat gaacgtaatc gctgatttga ttgtcgtgct ctgccactgc acccgtattg 3140821 atgatgcagt gggcgccgat gcgcgcatcc gcctgaatga tcgcgcccgc cataatcact 3140881 gtcccttccc caatgacagc cgacttgctg acgatggctg acgggtgaat caatgtaata 3140941 aaatcatctt tccccagtcc cagtcgctcc gccagctgtt ttctgacact gttattccca 3141001 acagcaatca gaaacagcac atcaggaatg agcctgcgca gttcagtaac ggctttcggc 3141061 ggtcctgtgt accattcttt tccgccttcg aacgttttga atttatcatc cagcaccgcg 3141121 gctaagcgcg tatctgagcg ggcgtttatc agctctctga tcacctttcc gtgaccgccg 3141181 tcacccacaa tggccacatt tttcatgagg acacatctcc gcttccggta aaccgttccg 3141241 cggtcacatg attggtttgc tgaatccctt ctgaaacaag gacctttcgc accgtcaaac 3141301 ataaaatttt caaatcgaga aaaaatgacc agttgtcaac gtaccaaaca tctaattcaa 3141361 atttcttttc ccaggaaatc gcgtttctgc cattgatttg cgcccagcct gtgatacccg 3141421 gcttcacctc atggcgccgt gcctgttttt ctgtataaag aggcagatag tccatcaaaa 3141481 gcggccgcgg cccgacaagg ctcagatcgc ccttcaggac attcaggagc tgcggaagct 3141541 catcaatgct cagctttctg atcagcctgc ccgttttcgt cagccggact tcatcaggca 3141601 gcagatttcc tttactgtcc cgttcatccg tcattgtccg gaacttatat agggtgaacg 3141661 gtttgccgtg caggcccggc cttacttgct taaagaagac aggtgatcct attttcagcc 3141721 tgacaacggc gatggtgaac agaatgatca cacttgtaca gcacaacaaa aaaatggcgg 3141781 ccgtcagatc aaaaagtcgt ttcaggatca aagattcaca gctcctttcg tttttcgaaa 3141841 ccgttttaat accagctgtc tttcctcttt tgtacaaacg agcataaaag cgaaaacagc 3141901 gtagcaaaag ctgactgtca ctcccgtcgc tatcaatgac ggccagctgt caatcttcac 3141961 aatgaactga attgccttac agaccgtcca ggcaaataca gcggctgaaa gaggcccgat 3142021 tatgccttta aggaacacgt gctttttgta gcctgtaatg cgggatacgt aaagcggcgt 3142081 aaagatggca ttttttaaaa taagagaaat ggcccctgcc aatgttatgc cgtacagacc 3142141 gagatgagcc ggcccgctca gcgtgaccgc cagcaccaca ttcaccgcac ctaacagcag 3142201 ggtaacaatc gccggtgttt tttgttgatt aaaagcggtc catatataaa acagcggcat 3142261 aaaggcgagg ctgacaacca agtatccggc atgaataaat aaaagcggtg ctatcgttga 3142321 aaaggacggt ccgagccaga ttgtcagaaa aggtcccgcc aatccgccca ataaggcagc 3142381 aggaagtgca agcaaaagac cattgagcct tactgcctta ttggcgtaat tcatcaatcc 3142441 ttccatatcg ccttttgaat aatatgaagt catgatgggc gcaaacaggg atgcgaccgt 3142501 tccggccaag ctgcgcaaaa gcagcggaaa ctggataatc gccgcgtatt tcccggatgc 3142561 agacgccccc agcatcaaat tggcggttaa cagatcaatc tgcaaaaaaa gcaggacgcc 3142621 gatttgattg acggagctcc atgcgcccgc ttgaaacagc tccttgcttg tacggaatga 3142681 aagatccttc atacgaaacg aaaaccacgg aatcagcttt ttgaagaaat agaaagacag 3142741 cacagacgca ataacagcac cagctaaagc tgcaagctgg atctgccaga ttttcggcgc 3142801 aaagcatgca aacaggagca gcacagacag cacccgtata agcatttgca ccgcctgaat 3142861 ggaactggtg atataaaggc ggttggcata aaatggtgca gcgccgaagc ccgccatcag 3142921 aaacgttaaa ataaacagca cactgccgat taaaatcgac aaacgcacat ctgccaaaag 3142981 cgcttgcggc acattcatga cgcggtcaat aaaaaaagcc gaacccgcaa gcggcagcaa 3143041 gagcagcaag gaaatcaaaa cagaggcggc taaataattg ctgatatacg catttgcttt 3143101 ctcccgctct cccctgtggg cagcaacaga aaagaaccga acgacaaccg agctgagcgc 3143161 cacggtaata accgaaaagt aattaatcac attttgtgtc aagtgaacaa agccaaacgc 3143221 ttcgacaccg agcgttttga caataaaagg cgtcatccaa accgatagga aaacagacaa 3143281 gagaaaagcc gtgagattcg cgctgaaatt tatcgtgaat ttcatgcctg cttcgcactg 3143341 cctttcattg tcccccgctg ctcgaaaaac agcttgatga gaaaagtgag ccgccattta 3143401 cacagtgcta ataccaaacg ctctcctctt aataatttct catgctgaaa cggtgtatgt 3143461 ctgacagcct gccgcaccat gtcataggat aaaatctgtc tgatcttctt tttgatgtct 3143521 ttcggcgaat tcggagaagc acaggcattt gccaaaagca tcggaagctg gtgcctgcaa 3143581 atgtacacat tcaaatcttc tttacatgcg cctgctaagc cgtagtgatt gtagaatgcg 3143641 attttagcct gatattgttt ttgaagatgt tcatccatcg ccggcttata agggatttct 3143701 gtcaggctgt tcgggttttc acgataaatg tacaatcctt catcaagcat tttcacccgc 3143761 tccgcttcgc gaaaagcgga caaattaaag ggagagtctt cagcaaaacg gatgtcttca 3143821 tcaaacagca gattcgccct ttcaaaaagc tcacgacggt aaagataacg ccatacatac 3143881 cagataaatc tcgtttcgtg agcatgttta agctgttcag tcatttctgg tttcgtcagc 3143941 acgcggtttg cctcaagctg cggcggcaca tatgtccgcc tgtccgatga ctgcttgtaa 3144001 aaaccgcatc cgacgatgtc aagctgattt tgctccgctt cttcagtcag cctctggaac 3144061 atggcggatg atacataatc gtctccgtct acaaagccga tgtaagtgcc ccgcgcggcc 3144121 tttattcccg tatttcgcgc tgaactaagc ccgccgtttg cctgatgaat gacccggatt 3144181 ctcgcatccc gttttgcata gtcctctgca atttcgcctg aacgatccgg tgttccgtca 3144241 ttcacgagga tgatttcaat atcagaaagc gtttgacgaa gcaaagaatc aatgcactct 3144301 tctataaatg gttcaacatt atacatcggg acaataatgc tgacgagcgg gatcattgcg 3144361 cttcaccgct gattttgtca cgcagacctt taaaatacac atctctcgga aagcctgcac 3144421 gggatgtttc ttttgttaaa agctcattga ctgcggctgt tacgcgctct ggctccggat 3144481 gttctatcag cttcatgaac gggatgtctt taagccattg atagccctcc atcaccttat 3144541 ggtcaaagga gcgaatgaca acacacggcg ttcctgtcag cgcgcaaaaa atcatgccat 3144601 gaagcctgtc agtgacgacg gcttctgcgc tttgcagctt agaccacagt gcttcaagtt 3144661 catgttcgcg tgtatcgcgg ctgacccggc ggccgatcgt tgtcgtaaag gatttgatct 3144721 cgccgaattc ctcacatagc gcagccttga cccggttcct ctgctcctcc tgaagcacgc 3144781 tttcctgatc ctcgcgcaaa cacatataaa ccccttcgcg ttctgcggga gccttgcttc 3144841 tgtctaaata cagcaccatg tccggctgct tcaaaattgt tttttcttga aaatgctgtt 3144901 tcataaattg atacgttgtt tcatcccgcg ccatcagcaa taggccgggg tgcgcattat 3144961 aaattttctg tgcccgtttc agctctttgc gccctttttt cgtgtcagaa aaatgagccg 3145021 ttgccggaag ctggacaacc cgatagtcat ggaatgtttt aatgatgaag cggcgcgtcc 3145081 actcctcata acggtataaa tcccccatgt ttccgccgcc gatgataaag accatatcct 3145141 ccggatggcg cgagcggatc aggctttttg ctgatttgta aatgtccttc atatcgacct 3145201 cgacgatgtc aaagtccggg tattcttgct caagaaatgc cttgctggca taagcaattg 3145261 cgtgatctcc caaattgtca tgggacggca gcagggtcag tatgattttt ttctgatgtg 3145321 ctgcggcctt taccggttga tctgccgctc ccagccaata ttgggacggg tatttgacct 3145381 ttagcagcag ccattctgca aaattgattt tcaacgattg taacgacatg tcctcaccct 3145441 ctgtttctca ttttgtactc gatcacccgc tgatacacag ccgatgccat agcgacgaac 3145501 ggaatcattc tgtatttcgc catcagaagc aggcatgacc gttttgcgtc aaaaggagca 3145561 gtacccgttt ttgaaagact ttcttgaaac accgggtccg cgcatatcac gccaacattt 3145621 ctaagctttt caaacagccg gcggctgccg ctcgttttcc attcattcag catacagatg 3145681 ctgctgtgaa gaacgataaa ggtatcaagc tccttgcgat actcctccag tttgttgttc 3145741 tcctgtaaaa acgccgcatt cgtctcatac agcgcaagtc ctgattcaaa caattttttc 3145801 tgatagcgct gcacaatgga ggaaaggtga attcgataat gatagagcgg cgtttttacg 3145861 taggatactg agcgggcgaa aaaatgagcc ctgaagctga aaaactgatc ctcgacatgc 3145921 tccagctcgc ctcggagcgg aaacgacagc cgatgggctt caatcatgct tcttctgtac 3145981 agtttgttcc atgaaaaccc tctgaccttc ccttcgaata acgccttgat atagtgctcc 3146041 ttcggctgat cctgataggt ttgggcaatg tcagagtcca tggttttgcc agtgtcctca 3146101 aactctgcgg cgtaattgca aatgaccaga tcagtttcat cgcctgctgt ccggagcatc 3146161 tgctcgcaat aatcaggctc aatccaatcg tctgaatcga taaacgcgat aaattcgccg 3146221 cgtgcagctt caatgccttt attccgaacc gcaccgagtc cctggttttc ctgatgaatc 3146281 accttgaacc tgttgtccat tttggcgtat tcttctgcga tatccgggct ggcgtcagct 3146341 gaaccgtcat tgacaatgat gatttcaata ttgtccattg tctggttccg cagtgattcg 3146401 agacacgttc tgatatatgt ttctgtgtta taaacagcga ctaacagact aaccgcaggt 3146461 gtttccataa tgaccggctc ctcgtgcata aattaccggg aaaaaatcgt tctgtaaggc 3146521 agaaccgatg aatcgaccgg cataagcaaa taactgtaaa gaaaataaca aacaacgata 3146581 gcgatataga taagagcgtt cgatttttca tcaaatatcc tgacgaaata agggactagg 3146641 atcatttgat acagaccgaa ataaatattg aatctggcaa aaatcacgtc ctttgtggcc 3146701 aaaaggccga acaaaaaacc tagcaggcac aaattgacga caatatcaat ttgcggccac 3146761 agactccgca gtcgttcttt atagcaaaat gcaaggaaca gcggcagaac caaaacagcg 3146821 attttgatca cattcattcc atttgtgttc gtcatgagcc atttttcata atggctgtat 3146881 gagctgtttt caagtacaac gacaaacaca gaaataaatt tttgatataa aaatgtcatg 3146941 ccgagaaata aagcggatag gccgaatatc gccggtgacc aggcttttct tctgacaata 3147001 aagtacactg gaatcataat cagcgccgac gaatgaaaga gcgagctgac cagcacaatc 3147061 aggaaatatc gcttccagtt cccgctaatg atataacgga tcgcccaaaa caaaacagct 3147121 gccaccatgt attgcctgat gccgttaaaa gatgcgtaat aatgaaaggt tcccaaaaat 3147181 aaaaagacac tcagctcaaa cggcctgcca tagtcggcga gtgtcttcat aataaagctg 3147241 taggtcacga ccgccaccgt aaaatacatg atttgaggat cttccgtgat gaaattcatc 3147301 agccaaagga gtgcggtaaa ccccggatct gtcgctgttt tcgctgtgcc gaaaccgaat 3147361 atctgccaca cattttgata atcgcccgcc aattcgtaca acagcgtgta cgtctgaaaa 3147421 tccgtgccga ctcgatagcg gagacctgac acgagcacaa gtgaagcgag cggaatccag 3147481 atcaaaagct tattcggccg ataccccgtg gcaagcgaat catcacggcc gccgcacatt 3147541 ttagcgaacc aagaccaaat aaatacaatc cccatattga cggcatatac aatcatcggt 3147601 tatggtcctt ttccgtgctg atgttgtata cattcagcag cgctcctaca ttttgctgtg 3147661 catcgtagcc aagttgagcg agtgtttctt tgatgaactc acgcttcggc ctgcctgcgg 3147721 cggccgccct tgcaatggtt tcagcccaga cgctgatcgg ctcagaaaga cttaatcttg 3147781 tgacaagccc gagaccggcg tcgacttttt ctgtaatgct gtctgaaatg atgcatggaa 3147841 gccccgacgc ctgcgcttcc acaagcacaa ccggcaagcc ttcgtacaga gacggcatga 3147901 caaatacatc gaatgttcgc atcagttcat ggatccgttc ttccgtgcct aaaaagagga 3147961 cgtctgatag caaattctgc tgccgcgcct cctcctctat ctccccgcac aacggcccgt 3148021 ctcccgccag aacgagctga aagcgaatgc ctctttcctt gagatgtgcg gcaagcttca 3148081 acaggaacgc gtggtttttc acttcatgaa accgggccac atggccaatg atgagccggt 3148141 cggctgcaat gccgcgtgct gctttttctt catcagccgc ctgcccattt ggggcgaaca 3148201 actcaaggtc aatcccgtta ggaagaaggt gaacacgctc ccgctccata ttggactgtc 3148261 caaataaaaa cctgcccgca tcctctccgc aggcacacag cgctgtcgca tttgccaaaa 3148321 tgagccgcct gaacacgagc agctgcaatc gatccttcca gttgaagccg gtcttccaag 3148381 acgtattgtg ggagtggcat accctgaccg gcactccggc gagccttgcc gcaagggcga 3148441 taaaacccgt ttggaaatcc gtgtgcgcat gaacggcgct gaacggccca ttttctttta 3148501 tcgcgtttct cacattcctc acaaatgtaa ggggattgct ttgcccaatg ctcgggacat 3148561 aaaaaagccg cccgcctaaa gataaaatct cttcatcata agcgcacgga tcatttcgat 3148621 acgttaaaaa atcaaattgc actttgcttt tgtccatctt ccgatataaa ttcattacca 3148681 tggtttccgc gccgcccctg ttcatgccgc tgagaacatg gagcacgcgc ttttggctgc 3148741 tattcatgct tgacaagccc ttccttttgg ttcatcactc tttttttatg gtagcgattc 3148801 atcacagctg caggcataaa ggcgcgaatt aacggttttg cgatatatat gtaatcagat 3148861 aaaggaagct tcaagcgtct gcacgcctga tagacaagaa tggcattgtc gattgaatac 3148921 gtaaatgacc gccgtttgaa tgcatcgctg tcttccctca ctttatacaa ggcttcctga 3148981 agattatagc ccctgaagcc ctcttcaaaa aagcgaagcc acaaatcaat atcttccatt 3149041 cgtctcgtcc gccgcaccga ccggtagcct ttcagcgtgc ggtaggcact cgctctcatc 3149101 ataatcgtgc cgtggcaaaa tggagtccct tttgccatga tgcccggctc cggaacagaa 3149161 ggcagaatgc gggcgcctct tacgccaaat tcatcaaaca caagcatgcc ggtgccaacc 3149221 acctgatagt gtcggtgctt ttctaaaaac gcgacctgct tttccagacg gcgcggaaac 3149281 gaaaggtcat ctccgtcctg acgtgcgata taatcgcctg tcgcatgcga aagacaatga 3149341 tttaatgatg cggcaagccg cttatttgtt ttgttttgaa tcagtttgat gcggtcgctg 3149401 taatgagcgg catactgctt cgcgatacgg agcgtgccgt ctgttgacgc atcatcgcac 3149461 aaaatcagct cccaattttt ataggattgg ctgagtatgg attctatgct ttctgccaaa 3149521 gtgcgttcgc aattataaat gcccataatg acagaaactt tcggtcctga gttcatacgc 3149581 ttttctcctt tgtatccata tccatgtacg cggaataaat atctgccatt tcttccaccg 3149641 ttcgcgcctc cgagaagcgc aaggctgttt ttcggccttc ctgtcccagc tttcggcaga 3149701 gctccggctt atggtaaagc tgttcaatcc ggcgggcaaa agcagcactg tcaccgattt 3149761 tgatcagaaa accgttttct ccgtcgcgga tgatttcccg atgcccgcga ttatctgtgg 3149821 cgatcgccgg ttgttctgcc gccattccct caagcacatt cataccgagg ccttctctaa 3149881 tgctggatgc gacagataca tccgcaagct gaatcaactc atgtatgtcg ctgcaaaagc 3149941 cgtaaaaaca gacatgggcg gaggcaccaa gcttttcagc taacgtttga tacgtatgtt 3150001 ccattgcccc ttccccggca aacacaaggc ggagtgaggg aattttttct tttagcaagg 3150061 ctgcggcttc aattaactgc ttctggtttt tgttcagatt gagctcagcc ggataaacca 3150121 atataaaatc atcttcacgg aacccgtgct tttctctgag tctttgctgc tctatcggac 3150181 tgacaggccg gaaacgctcg gtattgacgc caatgccgtg aattttctgc gtccttccgc 3150241 ccggcctttg aagtcctttc gcccgtatgt aatcctcttc attaatcgta atcaggcagt 3150301 ctgtatatgc tgaaagccat ttctcaaccg gatagtaaag aagccaattt ttcatcggtg 3150361 cccctttgca gaagtgaaat ccgtgcgctg tgtacagcac ctttgttccg tgccgccgtg 3150421 cctgcctcgc cgccagtctg gcgagaacgc cgccgaccgg tgtatggcaa tggacaatgt 3150481 cgtattcata agtgtcaatc actttcttca gctgcctata aacggccagg ttctgagggt 3150541 caaaaggtga cctgcgaatc gggatggaga atttctcatc cacatacggc agcttggttt 3150601 gtccgttcgc ggcgacatga acctcccagc ccatttgctt gaaccattta aaataaggga 3150661 ggtgaaaggc cttaaaatga taatcaacag tcgcgcaaaa caatatcttt ttcgtcattt 3150721 tcactccccc taatgaacgc tggcagccgt catttcttct gatgtattga ttgccgcaaa 3150781 cagcctcgct ctcaggtcgg cttccggcag ctcatgaaaa tcctcgataa agcgcatcag 3150841 caccggccaa tcgccgtcca ccgctttacc gatgtgaatt tttggaaaga tttgttcagc 3150901 atggacttca tttttgttca gcaattcttc atacattttt tcgcccggac gaatgcctgt 3150961 gaattcgatt ggaacctgct cagtcgtgta gccggacaaa tgaatgaggt ttttggcaag 3151021 atccacaatc tttacgggct ctcccatatc gagaacgaaa atttgacgcc ctttcgccag 3151081 tgccccagcc tgaatcacaa gccttgatgc ctcgggaatc gtcatgaaat agcgggtcat 3151141 tgccggatgt gttactgtca ccgggccgcc tttttcaatc tgttttttga aaattggaat 3151201 gacgctgccg cggctcccga gtacattgcc gaagcgaaca gcaacaaatt tggttctgct 3151261 gactttccca agattcataa taatcatctc tgcgaatcgt tttgtcgccc ccattacgtt 3151321 ggctgggttc accgctttgt ccgatgaaat cagcacgaat gtctcagttc ccgacatatc 3151381 ggctgcttcc gcgacatttt ttgttccgat aatattgttt ttgaccgcct cttctggatt 3151441 gtgttccatt aaaggcacat gcttatgggc agctgcatga tagacaacat gcggctcgta 3151501 ttttttcatc aaggtaaaca ttttatcgcg gtcctgcaca tcagcgattt ccgtatggaa 3151561 cacaatgtgt ttgccgaatc gtccgttcag ctctgtataa atcgaatgaa tgctgttttc 3151621 cccatggccg agcagaatga tttccttagg ctgaaacgcg ctgatctgac ggcagatttc 3151681 cgagccgatt gatccgcccg ctcccgtgac gagaactgtt tttcctttga tgcggttcga 3151741 aatttcgcta gtgtcgaggg ttaccggctt tctgccgagc aagtcctcag cttttacatc 3151801 tctgatttgt ccggcagttc gtgtgccaag cagcatttca tcaaaatgag gcataatttt 3151861 aatgcttact ccggttcgca cacattcttt atataacacc tgaagctcat gggtgcggag 3151921 tgaaggaatg gcaataataa tataattaat tttgagcttt tgcaccgcag gcatgatact 3151981 ttcttttccg ccgattacgg gcagccccat aatttctaat ttatgcttcg tttggtcgtc 3152041 atcaataaaa gcgacaggta tgatatcagg ttcatctttc gaaagcagct gcctgaccat 3152101 cagagtccca cctgagcccg ccccgataat cagcgcgcgg gacgaggcgc agcgtttttt 3152161 cctgatgctt tcgtttaata ctctggataa aatacgggtc cctccaatag acaaaagctg 3152221 aagcacccag cacgcggtta acagacggaa gaacatcgtg tgatacacag catactgaat 3152281 gacgccggtc acagcggctg aaagcgtaat gcccttaagc aggacaatca gctcgccaag 3152341 cccggtgtat gtccacacct gtttatactg attgaacagg aaagcacaca catgatagct 3152401 gaggagcaag ctgacagcgg taagcagtaa tgctccggag tcataaaatt gataggaatc 3152461 ttttaaaaat tgatatcctg caataactga atttaaaacg aggtaagtat ccagcgcaat 3152521 aatcattgac agtcttctcc ggtaactcaa ccttttcccc cctaattctt ttatcggttt 3152581 agctgcggcg gttttcgtct ctccaaaaaa tcggcagcag ctaaaccgac aatacgtcct 3152641 atgtatatat gagataagtg ggcatttaac ccatcctcac gccccgccag cgacgaccag 3152701 catctaaggc agcaacttca gctgcccaca gcagagccga gtgcctccat tgatacaggt 3152761 caggagacat cacctttaca aaaactagta ggaatagtgt tccgattttt tcattttctt 3152821 tttgtttaaa agagcgccta acagcttcgc attggattgt tccagtgcat cttttgcttt 3152881 cagaacggta tcggtttttg tttttccgct taaaacgacg agcacgctgc cgtctgtctg 3152941 atttgctaga atctgagcat ctgcaacagc caaaagagga ggggaatcaa agatgacgag 3153001 gctgaattgt tcatagatct cagatattaa atctcccatt gcttttgaag acaacagttc 3153061 tgccgggttt ggcggggtcg gcccgcttgt cagtacatat aagttatcga tcggcgtctt 3153121 ttgcaccgtc tcactgagtg aagcattgcc gaccagcaca tttgtcagcc cggttacatt 3153181 atcaacctga aacgtctgat tgatggtcgg ctttcttaaa tcggcatcca ccagcagtac 3153241 tttcttttcc tgctgctgcg caaagacagc cgcaagattc gctgcactga acgatttacc 3153301 ttcaccaggc acagaggagg tgacgaggat agatcgcaag ttggtctgga cagatgagaa 3153361 ctcaatgttt gtccgaatgg tgcgatattg ttccgcaaca actgatttat tgtgtaaaac 3153421 agatatttga gccaaacctc gccttgcttt cttttttcta aagatcactc gcttcactcc 3153481 ccgaaatgtt ttatcccgcg attccgccct ttgtggacat caggaacgga gcctaagcat 3153541 ggcaatccgg ttctctcgct gagctgccgt gcgcttttgc atgtatcatc gagaaaatgc 3153601 agaaaaaatg ccagtgtaat gccgcccatg acagcagcgc caaaagccat gaccatattt 3153661 cgcagcctgg ccggcttgat catcgggctt tccgaagcct tcgcctctga taatatatgt 3153721 acgccttgta cattcattct ttcatctact tctttttcaa acttgttcac taacgtgttc 3153781 gcaatctcag ctgctttcgc cggatcgtga tcctgaacgg caacgttgat tatttctgat 3153841 tcattttcac tgctggtaac cacttttcct ttcagcgagg aagccgattc agataggtgc 3153901 aattccgcct taacttcttc catcaaggca gtgcttttca taatcgattg gaacgtgctg 3153961 ctatactgaa gatttcgctg gatgtcactg agattcgagt tttcttcacc gtctgattca 3154021 tgaaccagca cctgtgtcga cgcctggtag gtcggtgaaa tgaccttaaa ttgcacaaaa 3154081 cccataataa gggtgacgcc gattgtgatg agcagaatca gcacgaatct gtgtctgaca 3154141 atcgcatata attctttgaa actcatattc tcattcatgt attcatagcc ttcagccttc 3154201 ccgcggctgg cttcccgcgc ccctttctgt taatgattgg attataaaag aaaacgttat 3154261 tatttaaaaa ttgcaaaata agccaataag ttctctttag agaacaaaat catgattttc 3154321 ctctaattta ctgcacttcc cttattattt taaattttat aaagaacgaa aaattcctta 3154381 taatgaacga aataacgaca ggaatagagg agaatttcat attatgattg gaagaattat 3154441 ccgtttgtac cgtaaaagaa aaggctattc tattaatcag ctggctgttg agtcaggcgt 3154501 atccaaatcc tatttaagca agattgaaag aggcgttcac acgaatccgt ccgttcaatt 3154561 tttaaaaaaa gtttctgcca cactggaagt tgaattaaca gaattatttg acgcagaaac 3154621 aatgatgtat gaaaaaatca gcggcggtga agaagaatgg cgcgtacatt tagtgcaagc 3154681 cgtacaagcc gggatggaaa aggaagaatt gttcactttt acgaacagac tcaagaaaga 3154741 acagcctgaa actgcctctt accgcaaccg caaactgacg gaatccaata tagaagaatg 3154801 gaaagcgctg atggcggagg caagagaaat cggcttgtct gtccatgaag tcaaatcctt 3154861 tttaaaaaca aagggaagat gatgatcggt taaagggcta acgttcgcat ctatagggga 3154921 aatctgttta taatggggga aaaagggaga gaacacaatg actcatcaaa tagtaacgac 3154981 tcaatacggc aaagtaaaag gcacaacgga aaacggcgta cataagtgga aaggcatccc 3155041 ctatgccaag ccgcctgtcg gacaatggcg ttttaaagca cctgagccgc ctgaagtgtg 3155101 ggaagatgtg cttgatgcca cagcgtacgg ctctatttgc ccgcagccgt ctgatttgct 3155161 gtcactttcg tatactgagc tgccccgcca gtccgaggat tgcttgtatg tcaatgtatt 3155221 tgcgcctgac accccaagta aaaatcttcc tgtcatggtg tggattcacg gaggcgcttt 3155281 ttatctagga gcgggcagtg agccattgta tgacggatca aaacttgcgg cacagggaga 3155341 agtcattgtc gttacattga actatcggct ggggccgttt ggctttttgc acttgtcttc 3155401 atttaatgag gcgtattctg ataaccttgg gcttttagac caagccgccg cgctgaaatg 3155461 ggtgcgagag aatatttcag cgtttggcgg tgatcccgat aacgtaacag tatttggaga 3155521 atccgccggc gggatgagca ttgccgcgct gcttgctatg cctgcggcaa aaggcctgtt 3155581 ccagaaagca atcatggaaa gcggcgcttc tcgaacgatg acgaaagaac aagcggcgag 3155641 cacctcggca gcctttttac aggtccttgg gattaacgag ggccaactgg ataaattgca 3155701 tacggtttct gcggaagatt tgctaaaagc ggctgatcag cttcggattg cagaaaaaga 3155761 aaatatcttt cagctgttct tccagcccgc ccttgatccg aaaacgctgc ctgaagaacc 3155821 agaaaaagcg atcgcagaag gggctgcttc cggtattccg ctattaattg gaacaacccg 3155881 tgatgaagga tatttatttt tcaccccgga ttcagacgtt cattctcagg aaacgcttga 3155941 tgcagcgctc gagtatttac tagggaagcc gctggcagag aaagttgccg atttgtatcc 3156001 gcgttctctg gaaagccaaa ttcatatgat gactgattta ttattttggc gccctgccgt 3156061 cgcctatgca tccgcacagt ctcattacgc ccctgtctgg atgtacaggt tcgattggca 3156121 cccgaagaag ccgccgtaca ataaagcgtt tcacgcatta gagcttcctt ttgtctttgg 3156181 aaatctggac ggattggaac gaatggcaaa agcggagatt acggatgagg tgaaacagct 3156241 ttctcacacg atacaatcag cgtggatcac gttcgccaaa acaggaaacc caagcaccga 3156301 agctgtgaat tggcctgcgt atcatgaaga aacgagagag acgctgattt tagactcaga 3156361 gattacgatc gaaaacgatc ccgaatctga aaaaaggcag aagctattcc cttcaaaagg 3156421 agaataaata tggggaaaac aggatacatt ggtgctgcca ttgttgtggc agcttgtatc 3156481 attattttgt cggccgtggt atgtttacgg gacacagtct attaccagcc tatgcgctgg 3156541 actggcatca tactgttttt cgcgggaatt gtgatggttc ccgcatactc agcaaaaaga 3156601 aaacccggaa aagagaagta attctctttt ccgggttttt atgtttatta taatcttccc 3156661 gcgcgaatat cgtctgtcat tccctcataa ggagccttcg aaatcacttc ttcgttgtcg 3156721 actccttcat ttttcagaaa tgtaatttcc gcaaattcag gtacaacgta ttttggatac 3156781 gtttcatatt tttcgcggga ttctttcatc aaatcaatgt ggtcattttg gtagcaaacc 3156841 gtaatttcag gatgttcatg cacccatttc gggaagaaaa taatgccatg catgcgtttt 3156901 tcatttggca taaagtttaa tgaaacatcc gtgccagtcg gctctgtcca agacacttta 3156961 tatacgcctt ctgtcagttt gacaatattc acttcctgat ctcgaaccca gcgtccggca 3157021 accattccgc tatgaattct ataatcaatt gtatggtcgt ttttaatata aatctcgtat 3157081 tcccatccgt tttcatacgt ataaatcatg tggcttccga taaagttttc catcttacac 3157141 actctcctta gtcttttact gtacttcata aatgtctagt agaacgtaat caggggttct 3157201 ttctgcggaa ccgataaaca agcggtcatg gagccattga tagacttcac tgcctgtttc 3157261 aaacgtcggt accgtacgaa aataaacatg ctccggttca ataatttccc cggctgccgc 3157321 ttgttttcga aacggcttgc tgacttgccg tattccattg ttttcaatgt aaatcagttc 3157381 atgatctgct gtttcaatca catacctggc agataaatct gttctgccgt tagcgcgaat 3157441 catttgtgaa tcggcaccgc ccggcaaaat acgtcccttt acttccccgg ttattgttcc 3157501 cgaacgaatc ggaatgaatc atctcagtcc caggcttgtc tcaccaatcg tgataggcgg 3157561 atcaaccttg atttctaaag aggcgaatgg ttttaaaacc ggcttcttca cgagaaccac 3157621 ctcaccttca gaaaaaatca tgtaactatt tacatgttca ctttaacacc attgcagtta 3157681 actgtcaaac aataggaaca taaaaaaaca aggactgttt gaagacagtc cttgtctgaa 3157741 gctagctttg ataagcaaga tatgtgctga cagtgctttt ggcaagacag gcagaggaat 3157801 ctataatcgg aatctcactt tgaatatgat ctaacaccgc atttaaatcc gtgcaggctg 3157861 aaatgatgat gtctgcatgc tgactgattt cttcatatag cgtctgccac aatgcttgtg 3157921 tatgctgcat atgatttggc tgtttgattg cggcgataag ctggttcaca gcctgctgcc 3157981 aatggtcctt gtgaataact tcttgtccat ttcccttcag aactttttgg tagatggcgg 3158041 attggatggt tggctctgtt cctaaaacca ccgctttttt tgcgggatgc ggaatctctt 3158101 ttatcgtttc ctcaacaata tgcaacatag gaactgacaa tgcctgctga atctcttcat 3158161 agtagacatg cgccgtatta caaggcagcg caatgaaatc cacgcctgtt ttctcgagct 3158221 ttaccgctcc gtcgataatc gcttttttca tctcgtcatg gtcaattgga cgatctgcat 3158281 agaagggcgt cgggcatgaa tagatcatca tgtgcggata gtcaatatcg tttgaagccc 3158341 catacagctt ctgacagtaa tcaatcacct tatcaataaa cggcgaggtc gatttcggcc 3158401 ccattccggc taatattccg atcatcaaat tcattccttt ctacttcgta cggaccgctt 3158461 cttcctctga gccatcctca tagaggataa agcttttcgc agcatcctca cctaatgtaa 3158521 actcgacttc aacagacaat gctcgcagaa agaaacgggt ttccgaggaa ggaaataact 3158581 ccagtctcag ctgtccggcg atctccaaat aaagccgttc attctcggtt gtcacctgtg 3158641 cagccgtccc atcctgcaac aggtagctgc caacatagcg gctgtatatc gccgtatcaa 3158701 ttgctttttt ctttttatca gcaggacgtt ccgggacatc atatggctgg ccaaatagaa 3158761 tatgttccgc cgccttcaga atcgcttgtt catattcagt atcctcttcc ttattactca 3158821 aatagatcag cgttttacga tgatcgatat atcggatcat catcgtcgaa tagccgggcc 3158881 atcctccgct gtggctgaca atccgccctt tttcaggact gttttgcagc acccagccaa 3158941 agccataatc aattgtttct ccattgttga ggcgcactgg agaaaacgca gattccttag 3159001 aagccttgct gatgaaatcg tcctgatata aagcctgatc aaatcgaaac aaatcgcttg 3159061 tgacagagtt aaccgtccca tctccctgta tgccatcgag atacacaaca tagttcgttt 3159121 cctccagctc atcagggagg acgtatgttt cggaatgtac atcatacaca tatccatatg 3159181 cataatgatc aattcgctca ggcgaaagcc tcctgttata cactcttgtt tcattcatgc 3159241 ctgccggtaa aaaaatactt gtttttataa aatccgcata gctcatgcca gatgcttttt 3159301 caatgataac cgccagcagc acataccccg tattgctgta catccagcct tcattcggtt 3159361 caaaataacc agatagcccc tcattcatca gcatatcgac aatatcctga ttcaccgcaa 3159421 tcttgtgtga atcccaattg gcaaaaaacc atcccatata atcaggaagc cctgacgtat 3159481 ggttcaataa atgccgaatc gttacgccct gatacggaaa accgggcagc cagcgatcca 3159541 ctttatcctc atagccaaga atccccttct cctccagcaa gatgattccc aatgctgtaa 3159601 aaggctttga caaagacgct aactcaaaca aagagttggt tttcaacggg cgtttttccg 3159661 tcatttccgc atagccaaaa gagtggtgat ataaaatatc gccaccctcc gcagccagaa 3159721 ccgtcccgtt aaactgatgt ttttcgccta atgtctcaaa taacgtctga agatgctttc 3159781 ttttattctg cttcattcct ccacctccca tatctctgta cgttactaac ctactaacgt 3159841 ttcaaatatt ttgaaaaatc cttcagttag agatcctttt taacccatca catatacctg 3159901 ccgttcacta ttatttagtg aaatgagata ttatgatatt ttctgaattg tgattaaaaa 3159961 ggcaacttta tgcccatgca acagaaacta taaaaaatac agagaatgaa aagaaacaga 3160021 tagatttttt agttctttag gcccgtagtc tgcaaatcct tttatgattt tctatcaaac 3160081 aaaagaggaa aatagaccag ttgcaatcca aacgagagtc taatagaatg aggtcgaaaa 3160141 gtaaatcgcg cgggtttgtt actgataaag caggcaagac ctaaaatgtg taaagggcaa 3160201 agtgtatact ttggcgtcac cccttacata ttttaggtct ttttttattg tgcgtaacta 3160261 acttgccatc ttcaaacagg agggctggaa gaagcagacc gctaacacag tacataaaaa 3160321 aggagacatg aacgatgaac atcaaaaagt ttgcaaaaca agcaacagta ttaaccttta 3160381 ctaccgcact gctggcagga ggcgcaactc aagcgtttgc gaaagaaacg aaccaaaagc 3160441 catataagga aacatacggc atttcccata ttacacgcca tgatatgctg caaatccctg 3160501 aacagcaaaa aaatgaaaaa tatcaagttc ctgaattcga ttcgtccaca attaaaaata 3160561 tctcttctgc aaaaggcctg gacgtttggg acagctggcc attacaaaac gctgacggca 3160621 ctgtcgcaaa ctatcacggc taccacatcg tctttgcatt agccggagat cctaaaaatg 3160681 cggatgacac atcgatttac atgttctatc aaaaagtcgg cgaaacttct attgacagct 3160741 ggaaaaacgc tggccgcgtc tttaaagaca gcgacaaatt cgatgcaaat gattctatcc 3160801 taaaagacca aacacaagaa tggtcaggtt cagccacatt tacatctgac ggaaaaatcc 3160861 gtttattcta cactgatttc tccggtaaac attacggcaa acaaacactg acaactgcac 3160921 aagttaacgt atcagcatca gacagctctt tgaacatcaa cggtgtagag gattataaat 3160981 caatctttga cggtgacgga aaaacgtatc aaaatgtaca gcagttcatc gatgaaggca 3161041 actacagctc aggcgacaac catacgctga gagatcctca ctacgtagaa gataaaggcc 3161101 acaaatactt agtatttgaa gcaaacactg gaactgaaga tggctaccaa ggcgaagaat 3161161 ctttatttaa caaagcatac tatggcaaaa gcacatcatt cttccgtcaa gaaagtcaaa 3161221 aacttctgca aagcgataaa aaacgcacgg ctgagttagc aaacggcgct ctcggtatga 3161281 ttgagctaaa cgatgattac acactgaaaa aagtgatgaa accgctgatt gcatctaaca 3161341 cagtaacaga tgaaattgaa cgcgcgaacg tctttaaaat gaacggcaaa tggtacctgt 3161401 tcactgactc ccgcggatca aaaatgacga ttgacggcat tacgtctaac gatatttaca 3161461 tgcttggtta tgtttctaat tctttaactg gcccatacaa gccgctgaac aaaactggcc 3161521 ttgtgttaaa aatggatctt gatcctaacg atgtaacctt tacttactca cacttcgctg 3161581 tacctcaagc gaaaggaaac aatgtcgtga ttacaagcta tatgacaaac agaggattct 3161641 acgcagacaa acaatcaacg tttgcgccaa gcttcctgct gaacatcaaa ggcaagaaaa 3161701 catctgttgt caaagacagc atccttgaac aaggacaatt aacagttaac aaataaaaac 3161761 gcaaaagaaa atgccgatat cctattggca ttttctttta tttcttatca acataaaggt 3161821 gaatcccata tgaactatat aaaagcaggc aaatggctaa ccgtattcct aaccttttta 3161881 ggaatattgc tgtttatcga cttatttcca aaagaagaac atgaccaaaa aacaaaatca 3161941 aaacagaagc cggactaccg ggcggcatat cattttacga cgccggataa atggaaaaat 3162001 gaccctcaaa aaccgatcta ttttgatggc aagtatcatt atttctatct atataaccgg 3162061 gattacccaa aaggcaacgg cacagaatgg cgccatgccg tctcagagga tttggtgcac 3162121 tggaccgatg aaggcgtggc gattccgaaa tatacaaacc cggacggtga tatttggacc 3162181 ggttccgtcg tggtggataa agagaacaca gccggcttcg ggaaaaatgc gcttgtcgcg 3162241 attgtgacac agccctcagc caaagacaaa aaacaggaac aatatttgtg gtacagcaca 3162301 gataagggaa aatcattcaa attctacagt ggcaaccccg ttatgcctaa tccgggcaca 3162361 gacgatttca gagatccgaa agtcatatgg gatgaccaag ataacaaatg ggtcatggtc 3162421 atggctgaag gatcaaaaat cggcttttat gaatccgata atcttaagga ctggcattac 3162481 acaagcggat tcttcccaga acaggcggga atggtggaat gtcccgacct ctacatgatg 3162541 cgggcaagcg acggaacgaa taagtgggtt ctcggtgcca gcgcgaatgg caaaccgtgg 3162601 ggcaaaccaa atacgtacgc ctactggacc ggaagcttcg acggaaaaga attcaaagcg 3162661 gatcagactg aagcccaatg gcttgactat ggcttcgact ggtatggcgg tgtgacgttc 3162721 gaagacagca aaagcacaga tccattagaa aagcggtatg cgcttgcctg gatgaacaat 3162781 tgggattatg ccaacaacac cccgacaatg aagaacggct ttaacggcac agattctgtc 3162841 atacgcgaac tccggctgaa ggagcaggat ggaacataca gcctcgtctc acagccgatt 3162901 gaagctttgg agcagctgac tgtttcaact gacgaaatag aggatcagga tgtgaacgga 3162961 tcaaaaacat tgtcgataac aggtgatacg taccagcttg atacggatct ttcttggtca 3163021 gagctaaaga atgcaggcgt caggctcaga gaatcagaag accaaaaacg ccatattgat 3163081 gtcggcattt tcgctgaagg cggctatgct tatgtcaata gagcagccac aaatcagcct 3163141 gacaaaagca atacctatgt cgaaagcaaa gctccttatg atgtaaacaa acgtaaggtg 3163201 catttgaaaa tacttgtcga taaaacaacg atagaagtat ttgttggcga cgggaaaacc 3163261 gttttttcaa atgaagtctt cccaaagcct gaagataaag gaattaccct ttattctgac 3163321 ggcggcacag cctccttcaa aaatataaca gtgaaacact ttgattcgat tcatgaataa 3163381 aaacaggggc ggcgcaggct gcccctgttt ttttattagg agcggtattc tctgttacat 3163441 attgggcatt gtaaggaata taaggctggt ttcaaaggag gaagcgaatg tctaaacaag 3163501 gaaattttca aaaatcaatg tcgctgtttg atctgatttt gattgggatg ggagccatct 3163561 ttggatcagc gtggctgttc gctgtcagta atgtcgcttc aaaagcaggg ccctccggcg 3163621 ctttttcctg gatcctcgga ggagccatta ttttgttaat cgggcttgta tatgcggagc 3163681 tcggagccgc tctgccccgt accggaggca tcattcgata ccccgtttat tcacatggcc 3163741 accttgtcgg ctacttaatt tcgtttgtca cgattgtcgc ttatacaagc ttgatttcaa 3163801 ttgaagtgac agctgtgcgc cagtatgtgg cctattggtt tcccggcctg accattaaag 3163861 ggtctgattc gcctaccatt tccggctgga tcttgcagtt tgccctatta tgcttgtttt 3163921 tcctgctgaa ttattggagc gtcaaaacct tcgctaaggc gaatttcatc atatcgattt 3163981 ttaaatatat tgtgccgatt accatcatta ttgtgctgat ctttcatttt cagccggaga 3164041 atttatccgt tcaaggattt gcaccgtttg gatttacagg tattcaggct gccatctcga 3164101 caggcggcgt catgtttgcg tatctcggcc tgcatccgat tgtatctgta gcaggtgaag 3164161 tccaaaatcc aaaacgcaat atcccgatcg ctttaatcat ttgcatcatc gtttcaacca 3164221 tcatttatac tgttttgcag gtcaccttta ttggtgcaat cccgacagaa acactgaaac 3164281 atggctggcc ggcaattggc cgggagttct cattgccgtt taaggatatt gcggtcatgc 3164341 tcgggttagg ctggcttgca acgcttgtca ttttagacgc cattctgtct cccggaggaa 3164401 acgggaatat ctttatgaat acgacatccc gccttgttta cgcctgggcg cgtaacggca 3164461 cattatttgg catattctca aaggtcaata aagatacggg gacaccccgc gcttcgcttt 3164521 ggctttcgtt tgccctgtcc attttctgga cacttccctt tccttcgtgg aacgcgctcg 3164581 tcaatgtctg ttcagtcgcg ctcattcttt catatgcgat tgcacccatt tcttcagctg 3164641 cgctgagggt caacgcgaag gacttaaaca ggccgtttta tttaaaggga atgagcatta 3164701 tcgggccgct ttcctttata tttacagcgt ttatcgtgta ctggtcagga tggaaaacag 3164761 tctcctggct gctcggttca caactcgtga tgtttttgat ctatctctgt ttcagcaaat 3164821 atacgcctaa agaagatgtc agccttgctc agcagctgaa atcagcctgg tggcttatcg 3164881 ggttttatat tatgatgctg atcttttcct acatcggttc tttcggacat ggtttaggga 3164941 ttatcagcaa tcccgtcgac ctcattttag tcgcgatcgg ctcacttgcg atttattact 3165001 gggcaaagta taccgggctc ccaaaagccg ccattgatta tgataaataa agaagcaaga 3165061 ggttttcttg cttctttatt ctttacaaac aaacatacac gcgataaaat gaatgagagt 3165121 cagtcattac tggaggtgtt cctcatgcca aaacaaacat cgggtaaata cgaaaaaata 3165181 ttgcaggcgg ccatagaagt catttctgaa aaaggcctcg acaaagcttc tatttctgat 3165241 attgtcaaaa aggccggcac tgcccaagga acattctatt tgtatttttc atctaaaaat 3165301 gccctcatac cggccattgc agaaaatctc ctcacccata cacttgatca aatcaaaggt 3165361 aggctccatg gggacgagga tttttggacc gttttagata tattaattga tgagacattt 3165421 ctcattacag aacgccataa ggatattatt gtcctctgtt attccgggct tgcgatcgac 3165481 cactccatgg aaaaatggga gacgatctat cagccttatt attcctggct tgaaaaaatc 3165541 atcaacaagg ccattgcaaa ccatgaggta acggaaggaa tcaattcaaa atggacggcc 3165601 agaacgatta tcaacttggt cgagaatact gcggaacgat tctatatcgg atttgaacaa 3165661 gatgaaaatg ttgaagtgta taaaaaggaa attttcactt tcttaaaacg gagcttaggt 3165721 actgcttaaa aaatgactgg gtaacaccgc tcatttttta atgccctaaa aatgactgac 3165781 gttcattcat aaaatagaga ggtgtttcat ttgaattggg ttcttgtttt tattgcaggg 3165841 cttttagagg ttgtttgggc ctcttccctc aaacatgccg attcgctttt ggattggatc 3165901 atcattttta tcttaatcgc ggtcagcttt atcctgttga tccgctctta tcaaaaaatc 3165961 ccgatggccg cggcgtacac tgtgtttgtg ggaatcggaa ccgtcggaac atatctgact 3166021 ggaattgttc tgggcgaatc cttctcagca gcccaaatgt tctttttagc tttattgctg 3166081 gctggcattt taggaatgaa attatttacg aaagaaagca aatctcagcc gggaggtgaa 3166141 aaataatggc atggttttta ttagtgattg ccggcataga agaaattata gctgccattg 3166201 ccatgaaata tatagacgga acaagaaaaa aatggccgat cattgtgatg actgttggat 3166261 tcggcttatc cttttactgc ctgtcccaag cgatgatcgt cctgcctgcc ggagtcgcat 3166321 atgccgtctg gactggcatt ggaagcattg gtgtttcggc ggtcgggctc atctggttta 3166381 aggagcggtt tcagctttca caggtgattt cactttgcct tatcctagcc ggcgtcatcg 3166441 gcctgcgtct tacgtcatct tcataaaatc aaggcatata cagctgtata tgcctttgcc 3166501 attaagcttc gtgatgtttt tgaagatgaa gcggcggcgg gatgagccag cctttgtttt 3166561 ttagcagcct taagtatttt gcgccggttg ccgctttcga catatgaaat tgcccaaaca 3166621 tcatggcaat atcctcacga atcgattgcc ccatcatttt gctgcatgtc acaagacctg 3166681 cagcattttc tgctgccgcg gaagccgcca catccggatc gagaaaccgt gcaccaggcg 3166741 gaatatcgtt aagatctgct gtcggcggtt caggagaagc cggcggcagc gccaccccgt 3166801 tttctttcag gatcgtgctg acctgtttga tttcatcttg gcatttctca atagactcac 3166861 gaagcagctt cttcaggtcg tcatcaccga catgattcaa tagcatttgg taattgccga 3166921 ccattttatt gcccgccatc acataactcc acaagccgaa tacctcaccg taatgcatcg 3166981 gttcatcctg cggatttccg cttaaaatac ccatgctcat tctcctccca tattcaatat 3167041 tgcacatttc ataacgtgcc caagcggagg aacatttatg tttcagcgga aaagatttat 3167101 gaaatgaaac aaaacaaaaa agacaagagt ggcaagttgc caaaccattg tctttcctgt 3167161 tgtttgattg gacgcactga agggattcgc accccgacag acaagatacc ggaaaccatt 3167221 caagtgcttt ttagtatgag tcattgattc tgtctttaat aaactttaac gagatggcgg 3167281 gatgctttgc ggaaaacgaa atacattttc ggggtcatat ttcgccttta tttctcgaag 3167341 ccgcgcaaag tttgcgccat aatattcttt tccgaagttt tcaatgtttt gatctggaac 3167401 attaacatat gaacctgcta catatggttg catcagctga cgcactcttt caactgatgc 3167461 aagatttgaa tcttcttgtg atttattttt ccaactagcc gtccattccg tataaaataa 3167521 tggatggcgc caaaaaaagg cagtttcgtc tttagggact ctgcttatag caccacccca 3167581 attgataaaa aagaaattgg cttctgttcc agtagcatct tccaaaaatt ttctcatgat 3167641 tgaaatgggt tcgtcagacc aaaaatcatg accccatgcc gaggagaatt taacactctg 3167701 atcatttctg ccagggatgg gttcgtcagg gtctaagaaa tctatagcat ctggatagta 3167761 taatgttttg atatctgctt ctgttggagt tcccgcatgt aataaaggtt ttaataatcg 3167821 aatcaattca gttttcgaac cgaggaaaat tccttctgca tgacacaaac catttatttt 3167881 gctgtaaatt tcaaggtagc atcctaatcg ttcatctaca aacggagccc atttctgcca 3167941 agctttaaat accgtttcta attgttccca cggccagata atattgaaga cggttgcagt 3168001 tttaggggca cgatgaactt tgaatgtata ttgggtatta tatccaaagt tacctcctcc 3168061 tccgcctcta gaagcccata gcaaatcctc attgtgagat tgatctgcgt gaataatcct 3168121 tccttttgca tctaccgttt tcagcgcgag aaggttatca cttataaggc caatcgatcg 3168181 tgagagtaca ccaaatccgc cgcccatcgt aattcccccg attccaactg ttgggctatc 3168241 tccaaacgga gccataaaac cgtctcgagc taatcccttt acaagcgggc caacgggaat 3168301 accagtttga acggttgcaa tagcgttttc ttcatctaag aaaactttat tcatgtcact 3168361 cacatcaata acaattcctc cacttactac tgaaaggttc ttatctaaag catggcgacc 3168421 gcttctgaca cgtaagggca ctttattctc acgagcccat ttaatggcat tacttacatc 3168481 gtatgaattt tgcgcaaaaa caaagacaag aggatagaca tccacataag ggttccaatt 3168541 cttaatagcc tctgtatagc cggggtctcc tttgaagatt acacgccctg tcaactgtgt 3168601 tgatcccata tattatttca ctcccaaaga aattcgattc agatactaaa atatgcagga 3168661 gctggataat cgcatagaca aatgatctac gaactataaa tataatacgc taaggccttt 3168721 ttcgtcggtg aggtctgctg agaaacattt ttcaaacaat tttgagcaaa cttcctgtcc 3168781 aatcctccaa caagcgtttt ttcttatcgt ttttaggagc agtgtccagt ttttttcgga 3168841 gtgaatattc gtttaggcca aaagaaaaga gagatgaaga agtgtttagt accagaggta 3168901 tacatccata caacagactc tagatcatca tatactgaat gtatgtagaa aggagacatc 3168961 agctttggca aaatatcgga ttatgacctt tgacggcggc ggtaccttag gtgctttaag 3169021 tttacaacta ttaaacagat tggctaggca aaacccgaag ttaattagtc gaacccatgt 3169081 attttcggga aattcaatcg gttcatttac tgcccttgca ttagcaagcg gaagatctcc 3169141 gagggaaaca cttcagtatt ttgaggatga aatcctaccc gcattcagca tttcccggcc 3169201 aggcggacct gttttcaacc aacaattacc ctattccggt tttattaaag cggtaagaaa 3169261 ttttttccca gcagatcttc aacttataga tttaagaaaa cgaattgttg tcccatcatt 3169321 caaattatac tctcaaaaac tggaccgttg gactcctgtc ttatttcaca attttcccgg 3169381 ctctccctat ttaaatgaaa aagtgagtga tgtcatactg cggagcagcg gtgctcccgc 3169441 gacgcaacgc gcctatcaaa actatgtgga cggatatgta gtagcaacga atcccagtac 3169501 agccagtatc gcgtttgcag ttggtaaagc caacgtgcca ttggatcaaa ttgcggtatt 3169561 gtccatcgga acaggtgaag ccccgactcg gttaagaaga gatacgaggg gatggggaat 3169621 ggtaagtgca gataacatac gtcccgaaaa tctgaagaac cttcctccaa attggggagt 3169681 ccttttggac aggtcgccta atgaaccttt actgccattt cttcagatga ttgctggcgg 3169741 taatgggtac tatgaatcca tggtcagtgc gaatcttctg ggagatcgtt ttttccggtt 3169801 agatccgcgg attccgaact tctccaaaac ggaccctgcc gtcgttcccg ctgtcattga 3169861 aattgcgaac aaaacaaact tacagcctgc gaatcaattt atagagaaga actgggggag 3169921 caaataatta tttattttaa atcaattctc gcttatacaa ttttgtccga gagaagattc 3169981 tcaaaataaa tacaggcaat gggtagaacc ggattttttt aaaggtttgt taatcacaag 3170041 ctaataagat gaatgaaaaa atcaattcat acttcttctt ttgaaagtga gggttcaaac 3170101 taaagaatgt aattgaaatg ttactctaag gtatgcaatt ccctttttca cacaaaaaaa 3170161 gacaagagcg gcaaatcgcc aaacccttgt ctttcctgtt gttctattgg acgcgctcgg 3170221 agggattcga acccccgaca gacgtggtac cggaaaccac cgctctatcc aactgagcta 3170281 cgagcgcata tagactgcgt tatgagaacg tcagcacaac taattatacg ataattcctt 3170341 tcaaataaca accctctatt tcgagaggcc gttttttaaa tagacaaagc atcttaattg 3170401 gcaatctgac atacgatggt ttgaacccct gtatttttgg ggaaaatggg aaaaagagac 3170461 gactttgcat atcaggccag ctttttgttt gacctttatt gaccaaaaat gtatcatgta 3170521 actacatact tacctaaaag gtgaaggagg agcattatga atttaatacc tacagtcatt 3170581 gaacaaacga accgcgggga aagagcgtat gacatttatt ctcgtctatt aaaggatcgt 3170641 atcatcatgc ttggatctgc gattgatgac aacgttgcga actccatcgt gtcacagctt 3170701 ttattcttag cagcagaaga ccctgaaaaa gaaatttctc tttacatcaa cagcccgggc 3170761 ggctctatta cagccggtat ggcgatctat gataccatgc agtttattaa gccgaaggta 3170821 tctacaattt gtatcggtat ggctgcgtca atgggcgcgt tcctgcttgc agccggcgaa 3170881 aaaggcaaac gctatgcgct tccaaacagt gaagtcatga ttcaccagcc tcttggcggt 3170941 gcgcaaggtc aagcgacaga aattgaaatt gctgcgaaac gcattctctt gcttcgcgac 3171001 aaattaaaca aagtcctagc tgaacgtact ggccagccgc ttgaagtgat cgaacgcgac 3171061 acagaccgtg ataacttcaa gtctgctgaa gaagcgcttg aatacggcct gattgacaaa 3171121 attttgactc acacagaaga caaaaagtaa taacacaacc tgcaagagct gcgtctcttg 3171181 caggtttttt tcatttcaag gaattgactc ccttattcta tactgctccc attcctcatg 3171241 taacagctca agcgtcaaat cactcgtctg cctcacaacc agatcagcac caagcatcgg 3171301 ctgtccttga ccgacaccaa ccgcaaacat ccccgcagat ttgattgcag aaatgcctgc 3171361 ttctgcgtct tctattgccg cgcaatcagc aggggaaaca tcgagcatcg ctgcagctgt 3171421 taaaaagatg tcaggatcag gcttcccctt cgcaagagtc gtcggatcaa caatggcatg 3171481 aaaatcatcg ataattgcca agcgtcttaa aatcttagga gcattgcgac ttgaagatgc 3171541 taacccgatt tttatatttt cgtttttcaa ttgacataga agcctgccaa tccccggtaa 3171601 aagatcttcc ggcgtcaatt tgctgatcag catttgataa tcgcgatttt tccgatgcat 3171661 aagctcttgt ttctccgcat ttgtatactt tgtttccgcc ccgccaaaga tcaatatgct 3171721 ttcaagtgac tcttctctgc tgattccttt tagcctttca ttcatgtctc tgtcaaaagg 3171781 gatatcgatt tgttctgcga tgtgcttcca agcgagaaaa tgatattcag cagtatctgt 3171841 tatcactccg tctaaatcaa aaatgaccgc tttcatatac taatgcccat cacagcttca 3171901 taaggtttga ggctaatact ctttaagtca gcccgctcct gcggatagtt tgaaattagc 3171961 actttccaac gctcatgaat cagttctgga ggcgcttcga acagagcctt ttcttccgat 3172021 aaattcacaa cgacaagaag cttttcccct cgatattctc gaaggtaaga aaagacctgc 3172081 ggatcattct cctgcaacag ctgataatcg ccatatatca taatcttata ttgctttcgt 3172141 aattgaatga gcttctgata gtaaaagaaa atcgaatctt gatcttccaa agactctttc 3172201 acattgatat cttgatagcg ggaatttacc ggtatccacg ggtctccggc tgtgaatccc 3172261 gcatgttttc cggcatccca ctgcatcggt gttctcgcat gatcccttcc ttttatcatc 3172321 acggctttga caaactcttt ttctgacatc gttttgtttt cgacgactag ttcacgatat 3172381 gcattcttta tttcaagatc atcatacatc tccagcggca tatcgctgtt gaccatgccg 3172441 atttcttctc cctggtaaat aaacggcgtt cctttcatgc cgtgcagaac cgttgcaaat 3172501 gccttcgcac attccttacg cagtttcctg tcattgcccc agcgggaaat aaccctcggc 3172561 tggtcatggt tctcaaaata aagggtattc cagccgacat tcattaaccc ggtctgccac 3172621 cttgtcatcg tcttttttaa agcaatcaaa tcaaacggct tgatctgcca tttcccattt 3172681 ggcgagtttt gttctttatc aatatccata tgttcaaatg taaagatcat attcagctct 3172741 tgcctgcttg catctgtgta ctttttcgcc tcttcaatat cagagccgtt tgcctctccg 3172801 actgtcatgc agtcgtaatg agaaagcact tccctgttca tctcttgaat aaactcatga 3172861 agacgtgggc cgttagagtg ataacggccg acaatatagc tgcggctgtg atccgtttcg 3172921 tagtccggaa aatcggtgta tttagaaata gagccaatca catccatccg ccagccgtca 3172981 acgcctctat ccatccagaa tctcattaca tcataaactt cccggcgaac ggcttcgttt 3173041 tcccaattta aatcaggctg ttttttcgaa aagtagtgca aataatactg ccctgttcct 3173101 tcatcgtatg tccacgctga gcctgaaaag atcgatcccc aattattcgg ctctgagccg 3173161 tccggtttag gatctttcca aagataataa tcccggtaag gattgtcctt cgacttgcgg 3173221 ctttcagcaa accaagcatg ctcatctgat gtgtggttca cgaccaaatc catgacgatt 3173281 ttcattccgc gtttatggac ttcatcaatc agctgaaaca tatcttcatt tgtcccaaac 3173341 ttttcgtaca tgtttttgta atcgctgata tcatatccgt tgtcatcctg cggggaatca 3173401 aataccgggg agagccagat gacatccgcc ccgaggtttt tgatgtaatc cagcttttga 3173461 atcacacctt gcaaatctcc gaatccatct ccattggcat cataaaaact gcgcgggtaa 3173521 atttgataaa cgacagcttc tttccaccat tcactcatta ggcgttctcc tttcacatcg 3173581 tccctgtagg acaaccggtt cctcataaac gttcatgtgc agcggctcgc cttttacaag 3173641 ctcaaaaata acgcgctttt cgtcaaccgt cacattgatt aatcgatttc gataattgat 3173701 gttgaatgaa tattcgtccc attctttcgg caaaaacgga gcaaatgaca gcgtctcatt 3173761 cgcggtgcgc atgcctgcaa agccatgaac gattgccagc cagctacccg tcattgaagt 3173821 aatatgcaag ccttcttccg tatcatgatt gtaattatca agatcaagcc ttgctgtgcg 3173881 cttatataat tcgagcgctt tcttttccag cttgagttcg gctgcgagaa tcgcatggac 3173941 agagggcgat aggcttgatt catgaacagt catcggctca taaaattcaa aatttcgccg 3174001 tttttcttcc attgtaaaac ggtcattaaa aagataaatg ccttggagaa catctgcctg 3174061 cttaataaaa ttggagcgga gaatcttgtc ccatgaccaa ttctggtaaa gaggccgttc 3174121 cgctggatct aattcgtcaa ctgtttgcag gtctttgtcc aagaacgtgt catgctgaac 3174181 gaaaatttgc agttcttcac taaatggata gtacatgtgc tggatgattt ctctccagac 3174241 ttccaattct acttcctgca catccagatg gcggcgtttc tccgctgaga tactttcgag 3174301 actttgtaga gtatactcca acgtccaagc cgcaatgaca ttcgtatacc aattgttgtt 3174361 aacgttgttt tcgtattcat tcggccctgt gacgccatgg atcatatact tattttttcg 3174421 tttcgagaag tgaacacggt cggcccaaaa tctgctgact gccacaagta cgtctatccc 3174481 gtattcttcc atatagttac ggtcgcctgt ataattgata taattgtaga tcgcataaca 3174541 gatcgcgcca ttgcggtgaa tttcttcaaa ggtgatttcc cattcgttgt ggcattcatc 3174601 acctgtgaac gtcaccatcg gataaagtgc ccccttcatc cccaattttg cagcgtttcg 3174661 tttggcagcc tccaactgat gatagcgata caaaagcagg tttttcgtca cctccggctc 3174721 ggctgtcgcc aaatacatcg gaacggcgta cgcctcagta tcccaatatg cggcacctcc 3174781 atatttctcg ccagtaaatc ctttcggccc gatattcaaa cgggcatcgc ccccgtaata 3174841 tgtcgagaat aactgaaaga tattgtagcg gattccttgt tgaagctcct catctccttt 3174901 aatctcaatg tccgcttttg cccatctttc cttccatcga tcagtgtgcc tccgttttgc 3174961 atcttcatag ccgttctcta ccacatccgc caaaagctcc ttggctttcg ataaaagctc 3175021 ttcctcccga aaatcacggg aagtcgtgac aatcacaaac tttttcaatg atgccttcgt 3175081 ttgataactg tagcgattct cgacatacat ttcagtcgtt ttaaagcttt catggacaaa 3175141 accctccgtc tcgtttgcca ttgcggctaa taccgtgaag cgcggtgttc caaatggatt 3175201 ttcgatcgtt tttgccgcta aatggccgct gtgagaatca gcacctttcg cttcctcctg 3175261 ccaaaactgt tcttggtagt tagaatcttc atttgccaca tttccatcca ggtaaggaac 3175321 aagcgtaatg acagcatctc ccgtcaagca ctccgcttca taatgaatcg cacagagttc 3175381 ttttacagca aggctaagaa accgctctga cctgattctg acggttttat cttgaatgcg 3175441 gacaacagcg cttcgccgca gaatcccctc tttcatattg agttctacct caaataattc 3175501 gattgggttt tgatggagat cgattttttc accgtcaaca tataggccta tgcccataaa 3175561 gttcatcgca ttgatcactt ttccgaaata ttctggatac ccgtttttcc accagcctac 3175621 tcgcgttttg tcggggaacc acacgcctgc aatatatgtg ccttggtgac tgtcgcctga 3175681 atagccttct tcaaaattcc ctctgacccc catatagcca ttggcaagag acgtcaggct 3175741 ttccagcagc cgtgtatgct ccttattaaa tgtatttgtt ttgattttcc attcatcaat 3175801 ctcaaataac cgctgattta tcatcatttc ctcccgaatg taagtttcca ttatcacggc 3175861 gggttttggt caaatatcta aatgcaaaag agatcatcaa agtaacgcca cacgaatgga 3175921 tcatcaatac agtaatcaaa tcaaaatgaa ccatgccgat agcagctgcc gcaaatgccg 3175981 gcagtgctga tgcgcaaatc gctatagagg ccgcttcctt gaatgatgca atagagacca 3176041 tgtttgatat ttttgtgatc cagaggccac ctgcaagaac aaacgttaac aaaagctgga 3176101 tcatagaaac caccgtatat gccagcatca tgatcatcgg cttatactgt gccaaccaca 3176161 atgtatcgat caagacctct acatcatgga cgtttggttt ctcgagctta acgtccattt 3176221 tcgcatagcc aacagaaaac cccgtttcgt tttgatcggt gatcaccagt tgatcaggtt 3176281 gaaatatgat ggcgttttca aatccagtta ctttcaatcg cccattttca ccgcttgtct 3176341 catattcatg cttcatatcg actgccatca cattctgccc atcttcaatc ctctcagagc 3176401 tcttcccgcc tgttagtttt ccgttcctga tttgaaaacc ctgcaattga tcagcaaatt 3176461 gatcattaac tccttgaatc gctgacggca tgaaagatga aacgctgaag cgatccattt 3176521 tcacaaacga aaccgctaac ggcgccatta agcaggccgt taaaaacaga aagagaaaag 3176581 agagctgcag ccagctgaag gtattcccat agcggcaaac acctgatggg gatgcagccg 3176641 ccttcaggca gcggatgata aagcttttat tctccagatt cttcattggc attacccctt 3176701 tgttccgccg gctgtcaaac cggacacaaa gttcttttgg agaaaaaaga atagaacgca 3176761 tatcggcagt gcggctagta tggcaccggc tgcaaataga gctacttttt gctgctgcgg 3176821 attagaaata aaggattgta atcctacagc gatggtcagc ctttccggtg agcgaagcag 3176881 aaatttcgtc agcaaatagt cgccaaacgg tgccataaac gcccaaagcg cttgtaccgc 3176941 gagcattggc ttaacaagcg gtagaacaat tgaagcgaaa atcctcagat gtcccgctcc 3177001 gtcaattcgc gcggcttcat caatttctct cggcacagta tcaaaataac ctttcatcag 3177061 ccacgtgttc atcggaattc cgccgccgat atagatcgct gttaaaaacc agtattgatc 3177121 gagtgcgcct attagcatcg ccaagacata aaaagcagtc agcgccgcca ttgtcggcac 3177181 catttgaatg attaaaaaga atatcaggct cttttttctg cctgcaaacc gatagcggct 3177241 gtacgagtac ccggcaagtg tcacaatcgt aacctgcaaa accatgaccg atagcgcgat 3177301 gacaagtgta ttgctgtacc aattgagata aagcgtttcg tcaaatagcc gcttaaaatg 3177361 atccaatgtc caagaacccg aaaaatcgag ctgaaaagcc gccgaattcc ccacacggaa 3177421 ggctgatgat gccgtaatca gcaacggata tataatgaca atacttaaaa gcgtcaaaaa 3177481 taaatacgta cagattttat taagcattct ggcagtgctc gcgttcacct acataacctc 3177541 ctcattgcca aaagcattcg attttttgaa agcaatcagt gaaattccaa tgacaatgaa 3177601 agaaattaac agtgtcacag ccgccgcaac ggaatattgg ggtgatgtgc ctgttgtcag 3177661 tttataaatc cacgaaatta agatatcggt cgatccggcc ccggctcccg cactgcctgg 3177721 ccctccctca ttaaataaat agatgatcga gaaattattg aaattaaacg tatactgagt 3177781 aatcatcacg ggtgctgtgg caaataaaat catcgggaat gtaatatgcc gaaaacgctg 3177841 aataaaagtg gccccgtcaa tctttgccgc ttcatacaat tcacctggaa tcgcctgaag 3177901 cactcccgtt accatgacat atatatatgg aaagccgagc cacgtttgaa tcataatgag 3177961 ggctgtcttt gtccagaaag gatcggtctt ccacgcgatc gcaggcagct cgacaaacgg 3178021 caggtgattg aataatggta tcacctgtgc attcaccgct cctatgctgt cgttaaacat 3178081 gttggaaaaa ctcatgattg taataaacgc cggaacagcc catggaaata agaaaatcat 3178141 tcgaaatatc cgcttgcctt ttataaaatc ctgattgacg aaaagtgccg tcacaatacc 3178201 taaaatgatt tgcagcgttg ttgcacagat tgtccagata accgtccagc ccagtacatt 3178261 cacaaatgtt tcacgatagg agccaaggaa aaaaatattt aagaaatttt taaacccgac 3178321 ccagtcaatc agacgattag gcggaatatg ataaaaatca tagtttgtta atgcaacaaa 3178381 cagagtcacc aaaaccggaa aaataatcac aaacaccatc atgatatatg ccggcagtgt 3178441 aaatagatac ggaaaacctt tatcgcccgc atgacagatc atatccttgg ctgttgtatt 3178501 gacttccaaa cccgccgctt tcatagcggc ggtcttacgt gaatcatgaa tattaaagat 3178561 atagaacatg aggaaaatca ttgtcacgat caattgcagc gtgccttcaa tcagcataaa 3178621 cagcgagtga tcttcaccgg gaacacttcc caatgtcatc aatccggtta gcgcctgtat 3178681 accgaaaacg cataattcaa aagcaaacaa gcctgtgatg gcaagaaata agagcccctt 3178741 tgacaactgc tgattcgcaa tctgcccaag tcctggaatg atcgataaaa gccctgcctt 3178801 tcgtttttgc tttgtaagtg tgtgatgttt attcattttt ccgccctcta ttcttccgga 3178861 cgctatcccg ccgttttatt tcacatactt ttctttaata ttttccttta tgacgtttac 3178921 agcatcattc gctgatgttt gtgtcgattt ttttcctgaa gctgcatcaa aaattaaact 3178981 ttccgctcct gtccatactt cagccatttc cggaatattt ggagtcggcg ttgctgtttc 3179041 atattgttta atcacagctg acgtcagttc attcttttgc tcatcggctt tcttccttgc 3179101 agccgtgttg gccggaactt cgtttgtatc ctcataaaaa gcgtaagcat tggcatcatt 3179161 tgcagcatac tcaagccatt tttcagccag ctcgggctct tttgtatatt tcgaggcaac 3179221 ccagcccttc ccgccagcaa aaggggcgta ttcttctcca tttggcaatg tcggaatggg 3179281 agccgctccg tagttcaatt tagcctcttt atagttggca gctgaccaag gaccgccaat 3179341 gatcgcagcc gctttgcctt ctaaaaacat ctgctgaata aagtcgtctg cgcttgaatt 3179401 gtcttgcatt cctttcggcc aatatgtctc aaaccatttc tccgcatatt tcaccgcttc 3179461 tacagcccct ttattgttca ggccgatgtc cccggaatct gtgccgtttt ttccaaacac 3179521 atatccgccg tatccagcca ataagccgta cgacatataa aagtcagtcc attttgctaa 3179581 aaatccggtt gattttcctt tttccgaagc aaacgcgaat cgaggatctt ccgttaactt 3179641 ttcaaggtct ttaaatgttt ttggcgctgt ttttaaaaga tctttgttgt aatacaaaat 3179701 aagtgtctca atgactagcg gcattccgta cactttgccg tcaactgtca cctgctgcat 3179761 ttctttatca ccaaagcttt ttgtgttaga tggcttaata tcaagtaaat gtccttgttg 3179821 tcccaaaccg ccgatccggt catatgcagc aagcataaca tcaggcgcat tacccgccgg 3179881 gccatcaaga ggaagcgctt ctaactgttc gaacatttgc ttttcaacaa tttttactgt 3179941 gacatcattt tctttttcga actttgtttt tatgctttca atgtattctt tatacgtttc 3180001 ttcgacagac acagtcagca cctttttgcc atcagagctt gctggatttt ttgaacttga 3180061 gcaggcggca aggccgattg ccaggaatga tgccgccaat atggcgaacc ccttttttaa 3180121 aagaaccatc tcttttcctc cttctattta cgaaactata acaattgtat tgtcctatag 3180181 aaagcggtta caacaacttt cgatttgtta ccgataacag aatgttatac aggggcggca 3180241 gcactcaaaa tcaaaaattc tcccggctga acggcaatga catcgtgatg ctgtagcggc 3180301 tgctctgtcc atgcatcaca gattttctta ttcctatcaa tattcaactc tcgtaaactg 3180361 acgtgttgaa ccacattccc ttgattaaag aaataaatca gtattttttc atcaagagtc 3180421 cgcgaaaagc taatgaaatc atttttgtcg tccagcagat tccactcaag atgtccttca 3180481 gtcaataaag tgttttcctg cttgcgtaaa gcaattaacc gtttcataaa ttgcagcatg 3180541 tcttggtttt gcttctcttt ttcccaaacc atacatttcc ggcataatgg atcattttcg 3180601 ccgttcagcc cgatttccgt tccgtaataa atgcatggtg agcctgtctg ggcaaacata 3180661 aaggccagca acgcgcgtgc tttcttctca tcattgcggc atctggtcaa aaggcgcttt 3180721 gtatcatggc tatccagtaa attaaacatc acctcattgg cctgcttcat tccattcatc 3180781 aaatgtgcat tgacacggtg agccatacgt gaagctgaga tcgtctggtc agcaaagtat 3180841 tcaatcatag gctctgtaaa agggtaattc atcgccgcat gaaattcatc ccctctaagc 3180901 cagggttcgg cagaatgcca gatctcacct aaaatataaa catcaggctt ttcagtagat 3180961 acagcctgcc taaatgtctt ccaaaaaacg tgatccactt catttgcgac atccaaacgc 3181021 cagccgtcaa tgtcaaattc gcgaatccag tacaaagcaa tatcaagcaa atatttctgc 3181081 acctcgggat tagccgtgtt tagcttcggc atatcagctg taaaagcaaa tctgtcataa 3181141 ttgtcgtctg tgacgggaaa agagtgaata tggaaccagt ccttatagcg ggattgatct 3181201 ccgtttttga cgacatcctg ccattgcgga gacgcgcttc ctatatggtt aaaaaccgca 3181261 tcaagcataa ttctcatccc ccgctgatgc agctggctga ccaatgtacg aaaaagctca 3181321 ggatccccga aatgcggatc aatagaaaag taatccagcg tgtcgtattt atgattagaa 3181381 ggcgcggaaa agatcggtgt cagataaatg ccgttcaccc ctaaatcctc taaataatca 3181441 agcttgtcaa caattccttg taaatcccct ccaaaaaaat cattgacgtc cgggtccttg 3181501 ctcccccacg gcaatgcatt cttcggtgac aagtcttctc ttccatttgc aaaacgctcc 3181561 ggaaaaattt gataccaaac cgttgacttg acccattcag gcgcttgaaa tgtatcagcc 3181621 tcgtgaacaa acggaaattt aaagtaataa tgaatcgttt ccagtgtttt ttcgttataa 3181681 gggcatacac ccgaacttcc gaaaaagatg tcttcatgat cgtctgttac aacaaacgca 3181741 tattgtaaac gcctaaatgg cggcaccact tcagcaaacc aatagtcatg catttctgta 3181801 gcagcaattt tcctcatcgg ctgctcgttt gccgaccatt tgccgtcgtt gtactcatag 3181861 ggatcacccc aaatgaatcg aatgtgatct gcatcacctt ttttcgtccg aatcttgata 3181921 tgcacagtcc gcccatcata agaataagca tctgtgctga atggctggtg atgaatcgct 3181981 gcatattcca tcatgtttcc ccctttgatt tccgttttat tgaagccggc tcatagtttg 3182041 aaagtatcat gatgaaattg tgggaacaat ccttttcacc ctgttaccga taacagaata 3182101 aggcgcttac agcgttgatt ctcgtacaat taactctggt tcaaaaaata gacttccttg 3182161 tgcagcgccg tcttcattca tttttttcag caacattttc gcacaggctt cccccatttc 3182221 aacaacaggc tgtctgaccg tagtcaagcg cggcgaggag atgcgatcaa gaaacacacc 3182281 gtcattcccg gtaaccgcaa cgtcttctgg aattcgcttt ccaagggatt gcgccgcacg 3182341 aatgacgccg agcgcgattc gatcagatgc gcagacaaat gcggcctgat tgtccatgga 3182401 tttcagcagt tctcttgcaa ggcattcact tttcttagaa ctgttgtcga tccgaaacat 3182461 attcgatttt ttaaagcttt tattcatcgc ccgtatatac ccctgttctc ttgcacgttc 3182521 gaaaggctca tctaaatcaa tgccaaaaaa gacaacttcc cgctccccca gccccataac 3182581 atggcgggtt gccataaaag tgcctttctc gttattcaca tcgataaagt catagcccat 3182641 ttcattttgt ccaaatacga cgagcggctt ctcaaaagct tttattacac cttcaaaatc 3182701 gttctttctc aagccggtgg caataatgcc gtcacattgg ccaatattaa gagaatttct 3182761 tgtcacaagc tggagagcat agtgattgcg atccagctcc ctgctgattc ctgtcagcag 3182821 gttcatgtaa tatggttctg tcgtatccat ttcctcaagt atcaatagtt tcacaacctg 3182881 tgttctgttt tgcacgagcg ctctcgccgc ataattaggg atgtaattca gctctttcat 3182941 cgcagaatga acaagctttt tcaattcatc cgtcaccgtc tcagggtgat tgatcactcg 3183001 tgataccgtc attttcgaaa catttgcttt tttcgccaca tctgacaatg ttgccatttt 3183061 catcccctcc ttatctgtgc ttattatcca aactagtgat aaagtcctct attactgcta 3183121 aatatacgat gcaggccaaa gagaaataaa aaagagattt cccttaagga aacctcactt 3183181 tgttaaaaac actcgatttt tcatggattc atacgctagg tggcagactc attctctcca 3183241 cttccatcag aaaatctctt ttttaaattt ctgtccactt tttttctaaa atcggataag 3183301 aataattttg catttgctca attaactcat ccggccgtga cgagctgtga atcagtttta 3183361 ggtgcgattc gttagaaaac ccttcttgaa tgctgtattt caccattttc atcattggtt 3183421 caaaatatcc gtttacattg tacagtccaa ttggcttttg gtggatgccg atctgtgccc 3183481 agcacagcac ttcaaataat tcttcatatg taccgaagcc gcccggcatc gagataaagc 3183541 cgtccgccag ctcgctcatt ttagcctttc gttcatgcat cccgtttact tcaatcagct 3183601 cagtcagatt ctgatggaca acctccccgc tgaacaaacc gctcggcatg accccgattg 3183661 cagttccgcc gttttccata atcgcgtcag caatcgtgcc catcaagcct acgcgggagc 3183721 ccccatagac aaggccgatt ccctgctcag ccatatacac gccaagctct gccgcttttc 3183781 ttttatacgc ttcatttccc ccagggtttg atcccgcaaa tacacaaatg gttttcatct 3183841 tgtcatctcc gcatctatat atcgtgttaa acattcaaaa acacactata tattgtccca 3183901 tcttcatgtg ataatatcaa tatgaaatac ataaagaatg caggagtgat gaggttgcag 3183961 ctggctgatg cagaaaaatg gatgaaagag ttttacgaaa aaagaggctg gacagaatac 3184021 ggacctttta ttcgcgtcgg ctttttaatg gaggaagccg gagaactggc ccgggctgtc 3184081 agggcgtatg aaatcggcag agaccggccg gatgagaaag aatcgtcacg cgctgagcaa 3184141 aaacaagaat tgattgaaga aatgggagat gtcatcggaa atatcgccat tcttgctgat 3184201 atgtatggtg tctctttaga agacgtcatg aaggcccacc aagaaaaact gacaaaacga 3184261 tttgagcatg cataaaaaag cggccgcgat ggccgctttt tttaacctgt gatttcatca 3184321 tggtgatcaa agaaatgctg ctttcctatt ttgtgaaaaa ggcctgtttt atgcagtagc 3184381 tccttcggct gcgattgcaa tcctacaatc atcagctttc cattgtggcg tttaattcga 3184441 ttcataatgt tcccaagcac cgcttcagct gacgtatcca tatagtgcac cttattcatg 3184501 agcagaataa gggttttcgg ttttttctgt acatgctcca gcaatgacga ttcaagggaa 3184561 tcaattgatc cgaaaaacag cggcccttct atggcataca tgctgacaga tggatcttct 3184621 ctcttcgcca gaacaggatg cgtttcctga ttgtggatgc gggtcgcttc gctcattctt 3184681 ctgataaaga acacgaatgc aagcagcaat ccggttgcca caccgatgat taagtcaaac 3184741 agaaccgtaa gggcgaaggt cgccgccaaa ataaaggaat cagcattttt cagtctcagc 3184801 atgtttgcga cttccttgcg ctcactcata ttccatgcga ccaccatgag aatcggtgcc 3184861 atactggcga gcggcacatg ggacgcataa ggcgcaaata caagcaggac aaggagaacg 3184921 actacgccgt gaacgacgcc ggaaactggg gaaaccgctc cgttttttat attggtcgcc 3184981 gttctcgcaa tcgctcctgt agccgggatt ccgccaaaca ggggcgctgc catattcgca 3185041 atcccctggc cgacaagctc cttgttgctg tcatgctttg agcccttcat gttatcagcg 3185101 accattgcgg acaaaatcga ctcaagtcct ccaagaagcg cgatgacaag cgcagccgga 3185161 aacagcataa ccattttatc caaagtaagc tcaggaaact gaaattccgg caaatggcgg 3185221 gggatttctc cataagttga cccgatcgtt gccatgcggt cagggaaaaa gacaaccgcg 3185281 accactgtgg aaataagaag cgccaacaaa gcgcccggca ctttaggcat caccttggcg 3185341 gatacaagca aaatgacgag cccgatcaca gctgtcaaaa tggcatacac gttaaaggtg 3185401 ccgagctgct gcacaatttc aaacatgttg tgatgaaagt tctcatgttt ttcaacattt 3185461 ctcaatccga gaaaattagc gatttgttcc gtaaagatca gcacggcaat tccggctgta 3185521 aaaccgacga taacgggttt gggcacgaat ttcattattt ttccgagctt aaacagccca 3185581 aacagtacca gcatcactcc tgccataaac cccgcaatca gcagattttc caagccgtac 3185641 tgcatgataa tgccgaataa aatcgggaca aaggcgcccg tcggaccgcc aatctgatat 3185701 tttgatcctc caaacaaaga aatacaaatc cctgctataa caacagtgta tagcccatat 3185761 tcaggctcga ctcccgaggc aatggcaaac gccattccta aaggaattgc cacgacacct 3185821 actacgatac ctgcaatcaa gtctttctga aatttctgca aattgtatcc cttgaatctc 3185881 cctgagaatc gcatattttg ttataacctc ccttatgagt gattgtttat aagctcagtt 3185941 tcataaccgt taatgaccac atcaagtttt cctgtttcag ggtgaatgac aagcccgtga 3186001 accggcactt ttttcggaag cagcggatgg ttcttaatca tgttcacact gtgggaaacg 3186061 ctttcttcca cgctgtgaaa accagtcagc cacgttttca aatcgagtcc ggcactcgtc 3186121 agcaaattca ggcagctatc ctccaccccg cgttcctttg ctttctcaag aatcgaggac 3186181 gcattcagcc ctgacattcc gcattcatga tggccgacaa tgcatacctc ttcagcctgc 3186241 aattcataaa tcgcgaccag tatgcttcgc atcacgcttc caaatgggtg agaaacgatg 3186301 gctcccgcgt tttttacaat tttagcatca ccgtttttaa gccccattgc ttgcggaaga 3186361 agttctgtaa gccttgtatc catacaggtg acaatgacga gctttttcga aggaaacttt 3186421 gtcgttttgt acggttcata cttcttctca ctgacaaacc gctgattgtg ttccaaaatt 3186481 gatgttaaag aaaccatttg attcatctcc catccatatg attttgcaag ccttcttacc 3186541 cagcttacag taaggaatta tagcatagga ataagccaag aaaaggtttt caaaaaaaga 3186601 cactataatt ggactgtaga atcaaaacat aaacatttat atctttcaaa gataataaaa 3186661 tttatattta atgcatccta taatccggct gcagttcgta tatcgatgat ttgtctgaca 3186721 aaaaatatgg gtgaattctg ataattaaaa aactttttta agcagattta gctgttcgat 3186781 cttcatttta agttcaaaag aaccagaaat taaaaaaacg cagctatatt tttaacatct 3186841 atttattttc gatataatga attagacaac agccataaag ggggagcctt gttgaaacca 3186901 tttgtattta tcacaaaacc gattcctgaa gagattgaag cattcatcgg tgaacattgc 3186961 cgttatgaag tatggcagga ggatacgctt ccgagtgacg tgctatttga aaaattaaaa 3187021 gaagcggagg ggcttttaac atcagggacg tccggaccgt caatcaatcg tgagttgctg 3187081 gaacacgcgc ctaagctcaa agtggtcagc aaccaatcag taggctacga taacttcgat 3187141 atagaagcaa tgaaagaaag aggagtcgtc gggactcata caccttatac actggatgac 3187201 acagttgcag atctggcttt ttcactgatt ctgtcttccg ccagacgtgt tgccgaactg 3187261 gaccgttttg tcagagcagg aaaatgggga accgtggaag aggaagcgct tttcggaatt 3187321 gatgttcatc atcaaacgtt aggcattatc ggcatgggca gaattggaga acaagcagcg 3187381 agacgcgcca aatttggttt tgatatggaa gtgctttatc ataaccgaca tcgcaaacaa 3187441 gaaacagaag acagcatcgg cgttaagtat gcagagcttg atacattgct ggagcaatct 3187501 gattttattc ttctcattac gccgctgact gatgaaacct atcacatgat aggagaacgc 3187561 gaatttaagt tgatgaagaa ttcagcaatt ttcgtcaata tttcccgggg aaagacagtt 3187621 gatgaaaaag cactgattcg cgctcttcag gaaggctgga tcaggggagc cggcttagat 3187681 gtatacgaaa aagagcctgt cacccaagat aatccgctcc tgcagctgga taatgtcacg 3187741 ctgcttcctc atatcggttc agcaacagct aaagtgcgct tcaacatgtg caaacaggcc 3187801 gccgaaaata tgctcgcagc gatccaaggg caaacaccga aaaatcttac aagagaattt 3187861 caataaatca aaaatccggt ctgataacag accggatttc atattacata cgctgaagaa 3187921 cagcacgctt ataaatatga cgggtgacga tataataaag agcctggaat acaaaataaa 3187981 tgaagatgac aattacggcc tcaagaaata aattggaatt cagcatatta cttaacgctg 3188041 catacgcaaa gcccgcgtga atcgtacctg cgataaatgg gatgaagaat aaaaatccta 3188101 tttgctttcc aaggatcgag tgaatctctt tgtccgtaac ccctatcctc tttaacgcta 3188161 acacctgcac tcccgtatct tctatttccg taaacatccg caaatacagc atgcttcctt 3188221 gcacgataaa aaacagcacg ctgacaaaca gaccaataaa cagcattaat gcaactccct 3188281 gcttcacaat ttgataacta ggagcacgtg tttgaaaatc agatgtatgt tctttcggca 3188341 ccatgttttc aagcttttca gagacatcca ccgtctcctg ccaatgctca agctcataac 3188401 ctaccattct catctgttcc ttcagcggca catcctgtga cagactgtca aagctctttt 3188461 cgctgacaac caataaacgg ctgactccat cgacagacat caatatccct ttgttttgct 3188521 gctttttcat gacataggaa agggtttttc ctgacttcat atgaaatgct gctgtttccc 3188581 cttctccaaa tgtgtctttc accatcattt gaaaagaaac attaataaat gcttcatttt 3188641 cttgtaaatg aataactggg aacccttttt cctttgcgac ttgattatag actttttctg 3188701 aaatcagcaa agcttcagct tccatcttct tatttccata cggcaagtct gactgaaaag 3188761 tgacaggaat ccctgtggca tccaccttat acgtgataac agcatgagct tttttcaatg 3188821 tattctcagc cgtctcaggc ttcatgacct gaaagcggga agcatccttt tccacccagg 3188881 aaacagactg aggaatgctt tgctcctcct gcctttgtaa atcggaataa aacatataga 3188941 tgacacctgt agctgttagt atgaccgctg taatgacaga ggttaaaaac agcatgcgtg 3189001 catgatcctt cagcctgaat atcatgttgg aacgcacaat gatatttgtg cctttgtaga 3189061 agctgtgttt ctttcggtac agcatgcgga aaaatgccac actgctttgg gtaaaaaaga 3189121 aatacgtgcc aattaacact aaaatcaaaa ttggaaaaac ccgaaacatc atgtcaattg 3189181 cattggctgt tgcagataga taataaccgc tgccaagaca tagcaaagac aatacagtga 3189241 gccatttcga ataaactggc aaacttttcg gctttttggc tgatttaatc agttcaatga 3189301 tttccagctt ccgaatccgt cccagtgata aaatgagcag cgtctgaaac aggatgagaa 3189361 agccggcaat tgtcatcaca aacgctttcg gcacaatggc aaacgaaatc ggcaccttca 3189421 cgctgagcat ccatgtcatg atcataaaaa acagttttga aaataacagg cctgctccaa 3189481 tgccggccgc aatcgccgca agagaaataa gtgactgctc ataataaatc atcttgcgaa 3189541 gctgctgctt tgatgtgcca aacagtgtca gcagcccaaa ctctttcttt cttgcctgca 3189601 aaaacgctga attggaatat gtgatgaaaa atatacaaaa cacaatgatg acgacaagag 3189661 ctgcgctcaa gcatgttttg acaaggcttc ctccatatat attgtcttca ttgacatcag 3189721 gatgaaaaat aaatgatgtg aagacaaaaa acaccgaaac ggcaaacaca cagcttaaaa 3189781 agtaggccac ataccgttgc agattcccaa gaatgttttt acgggcgata gttctcaaat 3189841 tcatgaaaat cgcctcccaa cacactcaag gtatccaata tactttgata aaacacctgc 3189901 ctgtttgttc ctctgtgaat ctctgaaaag aaacgtccgt ctttaataaa aacaatccgt 3189961 ttacagaaac ttgctgctgt ggcatcatgc gtaaccaaca aaatcgtcgc ttccttttcc 3190021 tcattcagct gagccagtgt gttcatcact tgctttgccg attttgagtc gaggtttcct 3190081 gtcggttcat cggcaagaat gagcgccgga ttgtgaataa tcgctctggc acaagctgcc 3190141 cgctgctgct gtccgcccga cacctcatat gtgcggtgat cgagaatatg ctttatttgc 3190201 agcgtatccg ccagttcatc caatcgagct tccatttctc tcagctttac cttatccaat 3190261 gcgagcggca agagaatatt ttcacgaatc gtcagcgtat caagcagatt aaaatcctga 3190321 aagacgaagc cgagttctct tctgcgaaac aaagccagct cttggtcctt taacgttttc 3190381 ggctgaatgc cgttgatcat catctcgccc tgggtcggct tatcaatggt agccagcaaa 3190441 ttcaaaagcg tggtttttcc gcttcccgac ggccccataa tcccgacaaa ttctcctttt 3190501 gacacactga gatcaaaggc gctgagcgct tggtatgata ttgttccttt atttgaatag 3190561 tatgttttcg ataggttcgt tgtttgcaac acgttcatgt tctgctcctc ctttttcttt 3190621 attataaaaa ggaagtcagc atcctcccat cgaactttct tgcaattccg ctccccaatc 3190681 ttacaatgct gtcacattca cgagggtgtc acttgaaaac acgatggtca tcacagtgcc 3190741 agccccttct tttgattccg catacagctt atggccgaga cggctgcaca cctgttttgc 3190801 taaataaagg cccattccag ttgcctcttt catggttcgt ccgttttctc cggtaaaaaa 3190861 cgcgtcaaaa atccgcggca gatcctgcgg cggtatgccg attccttcgt cggcaaccga 3190921 caagcgcgtc tcatgtccct gtgtttcaat ccggattgta atagggtctc ccacaccttg 3190981 ctttgaatat tttaaggcgt tgaaaaggat ttgctcaaca acaaaggaaa gccacttttg 3191041 atcactggaa atctgaacgg catttggcgg cacatgtaat gttggaaaaa ggcgccgctt 3191101 gataaactga cgtttttcct gattgatcag tgaacgaacc atttctgcca aatcaaaggt 3191161 ttgcggcttt acatcaaatg caaattcctc cagccgggcc gtttgcagca tcatatcaag 3191221 accgtggcga aatctctcat tctcatcctc cagctcctct aaaaacgtcg gaaaagagga 3191281 tgaggttccg ttttttcctt cctgaatcat taaggatatg acagataccg gtgttttcat 3191341 atggtggacc cattggttgg tgaaggtgta atgctgtttt tgctgattga tatattgtga 3191401 gagcctgctt tcgtattgct gcccgagtgc gttgatcatc ttcgtccaaa gcgcttgctc 3191461 tcctgttctt ggctttctgg ctttcaaaga ctgtccgatg tcattcgaag aagaggcttg 3191521 ttctgcaagc tttttaacat atgtgagaaa ggaaaattgc cgaacataat cagcagcaaa 3191581 acctgcggct aaaagagtac cgggcaaaat ccatatgtac atcatatttt ctttggaagg 3191641 ttctgcgccg ctctctacaa tgcttaaata cgcaatcagc atggcggacc ctatccctaa 3191701 taatgaaaat agaataatgg ctaagcggtc gatgagataa gtctttaaca ttccgcttca 3191761 tccttccgat tgacttgaaa ttgataacct tgtcctctga ttgtggaaat gcaatctgtc 3191821 agtcctgcat tctccagttt tctccgcagc cgattgacat tgaccgttaa cgtattgtca 3191881 tcgacaaaat caacgtcatc ccataacgcc tccaatagtt catcacgaga gacaattttt 3191941 ttatgctccc tcacaaaaat cgagagaagc tggaattctt tttgggaaaa caaaatccgg 3192001 acgctgttcc attcggcctc attctgatca ggataaatcg tcagcccgcc aagctccact 3192061 attctagatt cctgcggcaa agagggcgaa tattcaccat atgtgcggcg caggacgctt 3192121 ttgattttgg ccatcactac ctctagatgg aacggctttg tgatataatc atcgccgcca 3192181 ttttcaatcg ccattacctg attcagctca tcggtccgtg ccgatataaa gataatcggc 3192241 gcattggaaa tggtacggat ttgcctgcac caataaaacc cgtcaaaaaa aggcaggttg 3192301 atatcaagca gcacaagatc aggcttcatt tctgcaaatt ccaattttat atcattcagc 3192361 tgttcagcaa ttttcacttc atatccgtat ttttgaagat gaccgcccag caaagaagca 3192421 atccgctcat catcttccac aagcaaaatc cgatacacgt tgatccccct tatatgtaca 3192481 tcacgatgat ttttctagaa gattccaaaa ttattatagc atgtgcggaa tagtaaatcg 3192541 gtctttttct ttttgttatg atagaatgat aaaggtaaaa ttttcataat aggcaggtgt 3192601 cgtgatgaag aaaatcatgc tgtttctggc aatgacgtca attctttcag catgtcagcc 3192661 caactatacc gggaaataca tagaaattgg ggatacacta actgactata ccaaagagtg 3192721 ctttaaagag aatgaaattc cttataaata cgaaaaggga aaactgtata tcccagaaga 3192781 cgcatttgat acagcaatct acacttgttc ataagaaaaa gcttgcagat aacctgcaag 3192841 cttttcacgt tacaaaaaat gagtatttaa tttctcttca aatcctgaag ggccgatgtc 3192901 gcttttttga atgttaccgc cgttttcata aatcgtaaaa tggcgctctg acatgaccat 3192961 ccttccgctc ggcgtcagct ttgaggcaag cagggatttg ttaaaaggag atttttcatg 3193021 agagtgaatg atgtccttca tgttatctaa atcaccgaga tcactctctt caagggtaaa 3193081 ggcgtaccca atttgccagc cttctccttt gtccatcagc agaacatagc tgcccttttc 3193141 tgtctcttcc tttttgattc ggaatgaccc gactggtgac tgtaccgttt ctccggaaag 3193201 cggtatcggc tggagcgcca ggttgatgcc gaagccgata tcaacgaggt aatcgccgtt 3193261 ttccgcagac agccatacag cagcatgcgt cccttctagt gcccatccct cttgatcgcc 3193321 tgcataaacc gttcctcgaa tgagcttcac atgaaacccg gcctcacgca agacaaaata 3193381 aaggaaacca tttagatcgt agcataggcc gccgtgctga tctttgagca gacgtcgcca 3193441 tagctcttct tttgtgatct tataattctc ttttgcaagt acggcacggt tttcgaatgg 3193501 aaaacggtat gccattgctt taagaaaaag gggaagatcg ccgaagctga catggtcttt 3193561 ctcccagccg attttctgaa agcagtcttt tagaaagtca ctcattttta tcacctaaac 3193621 ttcttcttga acgtaagcag ccagcttctc cagcgcctct tgttcatctt ctccctgggc 3193681 aatcaaggta acctcagtgc ctgtgcttac cgcaaggctc atcagcccca tgatgctttt 3193741 ggcgtttact tttttcccat ccttctcaag aaacacatct gacgtaaacc ggtttgcttc 3193801 ttgtacaaac aaagcagcag gacgtgcttg cagtcctgtc tttaatcgaa cttccacttt 3193861 ctgttgaacc ataagatctc cccttttctt tacggttatt ttaaagtgac ggtttgccct 3193921 gtccgcagct gttctgcgat ttcgtcaagt tttctcagcc tgtgattgat ccctgatttg 3193981 ctgattttcc cgcttgctac catttcccct agctctttca gcgtcacttc ctgataatca 3194041 atccgcagct gcgcaatttc ccgaagtttt tcaggcagcg cctccaggcc gattctttca 3194101 tcgatgtatt taatattttc cacctgtctc agcgatgcgc cgatcgtttt gtttaagttg 3194161 gctgtttcac aattgacgag gcggttgacc gaatttctca tgtcccgaac gattctgaca 3194221 tcctcaaatc gcagaagcga attgtgagcg ccaattacgt tcagaaactc tgtaatcttt 3194281 tcagcctctt ttaaataggt aatatagcct tttttccgtt caagcgtttt gctgtttaac 3194341 tgaaactcat ttaacaggtc acataatgaa tcgttatgct ccttataaag agagaagatt 3194401 tctaaatgat acgaggaggt ttccgggtta ttgaccgaac ctcctgccaa aaatgctcct 3194461 ctcatataag aacgcttgca gcatctcttt ttgaccagct ctttcgaaat acttcgttca 3194521 aacacaaaat tctccccgag tatttttaaa tcctctaaga tcgcttttgc attttctgaa 3194581 aaacgcacaa tatagacgtt attctttttc agccgcattt tctttctgac cagcagctcg 3194641 accgacacat catattgttt tttcagcaat gtatagatgc ggcgggcaat cgccgcgttt 3194701 tcggtttgaa catcgagtac gagatggcgg tttgtaaatg ataaagctcc attcatccga 3194761 atgagtgcag acagctcggc attaatgcag cagtccttca cttccagatt cgttaattct 3194821 ttttttgttt ctgatgcaaa tgacatatag ccacctcatt tcaaggcttc attctttcag 3194881 taaatcaaca agaagagagg ccactttatg tgtatcgtga cgtattacgt catttttata 3194941 cgttacaatt tgatctctga tgacttcaag ccccatcgct ttcagctctt cgatatcaaa 3195001 atcaacagga cgcgccgatt ccatttcgta cttacgtttt atttcgtcgg gaatgtcttc 3195061 actgttcact aatatcgtat caataaaacc acagcccata tgctgattga gcgctttcac 3195121 atgatcagca gcggtgtaat ggagcgtttc gccgggctga gtcatcacgt tgcaaatgta 3195181 tacttttttc gccggcgcct ttatcacttc ttccccgatt tttgggacga gcaaattggg 3195241 aagaatgctg gtatagaggc ttcccgggcc gataataatc aaatccgctt ccctgattac 3195301 gtctattgtt tccggcagcg gatcaatctg ttcaggcgtg agaaaaacac gcttaatgcg 3195361 ctgtccgtat tctgggatcg ttgactcgcc tgagaccacg cggccatctt ccatctcagc 3195421 atgcaaaacg acactggcat tggcagccgg caaaaccttt cctcttacat tcagcacctt 3195481 gctcatttct gtgacagcgt gaaaaaaatc accggttata tttgtcatcg ctgccaaaat 3195541 caaattcccg agagaatggc ctgttaagtc attcccttta ttgaagcggt gctgaaaaag 3195601 atcttcaaca agcggctcca catcggataa agcggcaagc acatttctga tgtctccggg 3195661 aggcggaatt ttcagttcat tccgcagacg gccagagctc cccccatcat cggcaactgt 3195721 tacaatggcc gtgatgtcaa cgggtttatg ctttaggccc cgaagcaata cagaaagacc 3195781 tgtaccgccg ccaaagattg cgattttcgg cttttgtccc atcttatttc cggcttctct 3195841 tttcaatgtc ccggtgagta acatgagtat agtaatcctt tttgaaataa tcagctaaat 3195901 tctcggctaa tgtcacagag cggtgctggc cccctgtgca gccgatcgca atgacaacct 3195961 ggctttttcc ttctcttttg taagatggaa gcataaagct cagcagatca attaatttct 3196021 cattgaactt ttgcgtttca ttccacttca tgacgtaaga ggaaacctct ttatccttgc 3196081 cagtcagcgg ccgcatgctt tcgatatagt acggattcgg caaaaatctg acatcaaaga 3196141 cgagatctgc atcaattgga ataccgtatt taaaaccaaa tgacatcaca tttacggtaa 3196201 atgtctctcc ttggtttgtc gcaaagtgct tcacgatttt ttcacgcaaa tcacgcggct 3196261 tcatgtcaga cgtatcgtaa atgatttgag agcggccttt taattcctca agcagctctc 3196321 gttctagcgc gatgccttca agcggcaggc cagtcgctgc cagcggatgc gagcgtctcg 3196381 tttctttata tcttgtgacg agaatggaat ccttcgcgtc caggaataaa attcgcggtg 3196441 tgatccacgg attttcggcc atttcatcca gcgcttcaat cagccggtca aaaaattcgc 3196501 ggccgcgcaa atccatcacg agcgcaactt tgctcatttt cgaatttgat tccttcatca 3196561 gctctaaaaa cttcggaagc aatgaaggcg gaagattatc gacgcagaaa tagccgagat 3196621 cttcaaagct ttggatcgcg acagttttcc ccgctcccga cattccagtt ataatgacaa 3196681 gctgaatatc atgtgattca ctaacactca tctttctccc ccctgacttg tctttctatt 3196741 tgatgtgctg cgggtctaaa cgataactga gcagctcaaa ttccggtgta tacgtaaatg 3196801 tgccgtgcag cagcccttgt cccttcatca taaaatcaag gatatggccg tctccagggg 3196861 ccataggcag gttctgaatg tcattgacat cgtgccactg cagtttgcct tcctctgatt 3196921 ctgatacatt ttgtcctgta tatgaatcag cgacaaacgt aaacatcatc cactcggaga 3196981 caatgtggtc accgtcttta ataataaagg taaaaacgcc ttttaattga ggatttatga 3197041 tatagatacc agtctcttct ctgtactctc tgatgacgga gtctctgact gattctccgc 3197101 tctccatctt gcctcccggc gcgacccacc atccgcgtct cggcttttga agcagaagaa 3197161 ctttgtcatc cgtctgaagc acacaatttg tcactctttg caagtacgtc acctaacctt 3197221 cgtcctgtca tcgtctcttt attataccgc ttcaagatgc ctcccacaat gaagagacat 3197281 tgacaatctt ttcttctatt ttacagcata ttcattcctt aattcagatg attttgctgt 3197341 aactggaatt ctcttttatt tatggacaaa aaaaggacac ggataactgg agaatccgtg 3197401 ccaaaaaagt gtattcatta taaaaagggg gtcaattact ttattaatca taaccgaaaa 3197461 gcattacaca tgtgttacag cggaattaaa acccagtaac gtaatgtgaa actcgtatga 3197521 cagccctttt tattttaagg ttttcagcgt ttcttggagc tcttcgacat aatgttgtac 3197581 gctttgtgcc gcaatgcttc cgtctcctgt agccgttacg atttggcgca gtgatttttc 3197641 gcggatgtct ccggcagcga aaatcccttc aaccttagtt tccatgcggt cgtttgtttc 3197701 gatatagcct tcttcattcg taatgcccag gttttcaaac ggtttagaca gaggaagcat 3197761 gccgatgtaa atgaatacgc cgtctgtttt gaattcactt tcttcaccgg ttaccgtatc 3197821 gacaagcgtt acgttaccga ctttgccgtt ttcctcatga atttccttca cagttttgtt 3197881 ccataggaag tcaacttttt cattatcaaa tgctctcgct tgaagaatac tttgagcacg 3197941 gagtttatca cgtctgtgaa caatcgttac ttttgaagcg aaacgagtca gatatacgcc 3198001 ttcttcaacc gcggaatctc cgccgccaac aacgacaagt tctttgcctt taaagaaagc 3198061 gccgtcacat actgcacaat aagatacacc gcgtccgccc aattcttttt cgccaggcac 3198121 gccgattttt ttatattccg cacctgcagc aatgatgaca gcacgggctt tatattcctt 3198181 tgaaccagct ttgactactt tgtactcttt gccgtcaatg acctctttaa tatcgccata 3198241 agcgtattca gcgccgaatt ttttcgcgtg ttcaaacatt ttgttagaaa gctcaggccc 3198301 aaggatactt tcgaatccag gatagttttc tacatcttcc gtattggcca tttgtccgcc 3198361 aggaattcct ctttcaatca ttaatgtcga taaattcgct cttgatgtgt atacagcggc 3198421 cgtcatccca gcagggcccg cgccgattat aatcacgtca taaatttttt cttctgacac 3198481 actattcact ccttaaacca tcttttcaag tttgggctct ttcttataag ataagaatcc 3198541 ccatcaaacg tattccttac ccatatccta taaaatctca tggtgatacg ctattttttt 3198601 gctcaacacg attaaatgta ttcgaaaagg gtatatgtta ataaagaaag agccttctgt 3198661 ttatagaagg cccttgtcat atttattatt gaacaacacg tcttacaaca cctttaaatg 3198721 ctgctttcca gtaaggattg ctcatagagt caacagatac gccatgagat gtattgtcgt 3198781 ttaggaaagt accgtttcct aagtagattc ctacgtgtcc atttgttttg taagtgtcaa 3198841 agaacacaag gtctccgcgt ttcatttcag acgcgctgac agcttgtcct ctgccaacta 3198901 acgtatcagt tgttgttccg cctacaggtc caaggttaac acctgcagaa gcgtatgccc 3198961 agcgtacgaa tgatgagcag tcaaaaatac ggttgttgat atcagactga gtgcgtccgc 3199021 cgccaaactt gtacggagat tgtcctacaa tgcttgaacc aacgctgatc gcgccttcaa 3199081 ttccgccaga gttgctgata acagtgccgc ctgaattgct gtttgagccg ctgctcttct 3199141 tagaagatga gccgtttgac gaactgtttg atgaaccgtt agaagaattg tctgaagaat 3199201 tgtctgaaga atcatcagat gagcttgctt ttgatgattc agttgtcgcc gtttgactgt 3199261 catctgtttg tgtttcatca gatgcttttt gtgcttcttc ctgctttttg atcaaagcag 3199321 ccgctgcttc ttgttctttt ttgatgcgtg cttgttcagc ttcagtattt gctttttgat 3199381 ttgcaagttc agacgcctct gattttaatt cagaaatcgc tttagccgtt ttcttttggc 3199441 ttgcttttgc ttcgtcgaaa agcttgtctt tttcattaag ctgtttatca aggtcttttt 3199501 gcattgtttc taatttagcc aaggcagctt gaacttcttt cagcttgtca ttcaaatccg 3199561 cttcagaatc ttcgagcttc gctttatcct gctcttgctg tttgattaaa tctttgtctg 3199621 cgtccacaat agatgaaacc gcagtcgcac gagagataaa gtcaccaaag cttgttgatc 3199681 ctaaaagaac atctatgtat ccttgagatc cgccgctttc ctgtaaagaa cgaacgcgtt 3199741 ttttcaggat ttcattgcgt ttttcgatgc gtgcttcagt ttctttaatc tcttttttca 3199801 gttttttgat ttcttctttt gttttatcgt tttcttcttt tttatcttca atcttgttgc 3199861 ttgtatcaag cgccttatcg ttaatgtctt tcagttcttt ttcaatcttt gattgatttt 3199921 cctgaagctc ggttaattct ttttccttcg cttcaatgct ggaagcaacc tcagattgct 3199981 tgctttcgat tttttgtttc ttttcatcta atgtttccgc cgatgcagtt ttacttgtaa 3200041 atgggatcaa aaaactgctt gtcccgatga cggaagccaa accaagtgta attaaactct 3200101 ttctcacttt ttatatcctc ccttttactg tgaacctgtc ctcatttgga atcgtatttt 3200161 gaacatcaag tttcgttcct catactctac gaggaatgat ggttgtttat ggttaattat 3200221 tctgtgcatc tcttattctg gttgtatagc gtttatttca catcatatgt aaaaaacact 3200281 aattccttat gtacgagaat cattatacca tcaagtttcg acaaattagc gataaatttt 3200341 attacattta tgtttcaaac agatgtcaag tcacacatca tttgtcattt ttcttaagcg 3200401 tgtaaaaaaa ctgtcgatat tattttctta atataatcta tctaacaaaa aaagagtcga 3200461 ttaaataaat caactcttta aaatttacta ttctagaata tcatcaatat atttcatata 3200521 tttcgtcaaa gttgccggag agatgccgaa tcgggccgct gtgtcttttt tcgtgtcttg 3200581 cttgccatgg gcttctttcc aaatataaca gatggctgct gcccagcctt tctcattctt 3200641 caacggagca gctgcacgaa tttgctggat gacatgaaaa acccagcagc tcatgacttc 3200701 tgttttcatc tcttcttttt cagcttgctc taatagtttg accgtttgat aagcgaaaag 3200761 tgcatcctct gaaacgtcag cagccgcaga atctccattc agaagcagct ttacaaaatg 3200821 agtttcaaaa ggagcggtaa ttctctttga gcgtatcacc gcttcaagat gctctgtttc 3200881 tccctttgtg ctgctgatat aataggctgc gagtcgctgc tccacagatg aaggaagagc 3200941 ttccctccgc tcaatccaag gcgccgggcg gtcttcgccg ggatattgcg actcgacttt 3201001 tctccagatc gtctcggcaa agtcggtatg tcccgtaaaa taagcagagc aggaaagcca 3201061 gtaaaagaag gtgtcgtcac cctcaaagcc ggttttatat aatgatttga gccatttata 3201121 tccgatctcg tagcggccga caagcgccaa agtagcaccc aatttataac gctgctccaa 3201181 tagcatcgga tagacattgg agagctgatc actcaattcc gccacttttt cgtcttctct 3201241 ttcataatag tagaaaacga gaagattgca taaggcgtga agatttcctt cattatgaga 3201301 aagcacttca taagcggttt gcttcgcttt tacaacgttt cctgaataga aataggcaag 3201361 cgcgagattg ttgtatgctg accaaagctc cggatattca gttgtgattt cctcaagcgc 3201421 cgcaaccgct tcagcaagct ggccgctttc cagcaatgac tttgcccgat cctgtttcac 3201481 cagcagttca tcctgatcat acaacgaatc ctcaatgccg tcgtctccta aatcgagcaa 3201541 atcaagcaga ctatcgtttt cttcggcgaa ttcaccatcc gggtccgcat cagaataagc 3201601 ggccgcttct ttataagctt cctggaagag ccccagatgg gcaaagttat tcgctttaaa 3201661 gtaatggcac tccggcattt cggcctccag atttgccatg atatagtcaa gaagatcgtt 3201721 cgactcttga tactggccca tttccgaata aatgaccgca agctgtgaaa gcatctctga 3201781 atcctccggc tccaaatgaa ccgcgcgctg aatcagtttg cttgcccgtt ttagattgcg 3201841 ctctttatac gctttcaagc ctttatgaaa aaaatattgt ccatcttgaa gcagctggac 3201901 aatttgtgcg tgatttttat gttcagaagt gtgttttccc acaactaccc tccgttttat 3201961 acaatattac cgtcagtagt ataccataaa tcgtaagccc ctcaatagtt caaaaggaag 3202021 gattgggaaa atccctcctc ttttttattg gctgattcga ccaaaattta cccggctttg 3202081 ttttctaagt ccgcattcat tttcagctgc tgttcagcaa aatcccggta aaggccatgg 3202141 gaagccatta actcatggtg tgttccacga ccggtaattt cccctttttc aacaaacaaa 3202201 agctggtccg catctacaac ggtagatagg cggtgagcga taacaatcgt tgtgcggccc 3202261 tccatcagca cctccagcgc ctgctgaact gatttttcag attggctgtc gagacttgag 3202321 gtagcttcat cgagcataag aatgcttggg ttacggagaa gcgctctcgc aatcgcgatt 3202381 ctttgccttt gtccgcctga cagcataatg ccgcgttcgc ccacttctgt atcaaactga 3202441 ttcggcagct cctttataaa attgagcgca tatgccatct ccgcggcttt ttcgatctca 3202501 gcatccgtca catctcgttc taacccgtag caaatatttt ctctgattgt cccggacatt 3202561 aacgggcttt cctgtgatac atacccgata tgctccctcc acgattcaag cgagtaagta 3202621 tcgaccggct cgtcccccag ccgaatggtc cctgcagtcg gagaataaaa gcgttcaagc 3202681 agcttaaaca gcgtcgtttt tcccccgccg ctcggaccga cgatcgctgt cactttccct 3202741 gcttcaatga cggcgctgac ctcttttaag atcagctgat caggcttata tccaaaagac 3202801 acgcgatcaa gctggatagg cagatgtgca ttttcaattt gttttcctgt cactgtatct 3202861 tcctcttcct ctgccaaaat ctcaatcatt cgttctgttg caccgattga tttttgcagc 3202921 tgtgtgaaaa acgttgtaat ctggcccatc ggcataataa tttgaaacaa atataaaata 3202981 aaagccacga gcgctccggc tgtgagctcg cctgatgaga cctgcatgcc gccatatccg 3203041 atcactgcga caagcgctgc cattaacacg agtgaaataa gcgggccgac aagcgattga 3203101 accttggctt cacgaacgcc aagcttaaat aatgaggaaa tccccatctt cccgcgccca 3203161 tattcgacat cctccgcatt tgaagcctta acaagtctga tttccgggag aatttgatta 3203221 agcaggcctg taaaacgagc cgtttcatct tgcgtttccc gtgaaatgga gaacattttc 3203281 cgtccaatcg gcaccaaaat aagagcggcc agcggaacga ccactaacac aagcagtgtc 3203341 agcttccagt tcataataaa caagattgtc aatgatccaa tgacagaaat gatgcctgta 3203401 ataaatccgc tgatatgggt tgtaatcaat tctttgacca ccatcgtatc gttcgttaca 3203461 cggctgactg tttctccgga agcatttgta tcgaaataag agacaggcag cttaattaat 3203521 ttcttccata ataactcccg cagcccggaa atgatttttt gtccattata gttaagcgca 3203581 taggtggcat aagcgcttaa acccgcctga acgaaaaaca ccagcgcgat caaaccgatt 3203641 tgcgtgcctg acagatttga catagaaaaa ccatcgacaa gctgcttcgt taataatgga 3203701 atgagcaggc tgaccagcgt ggttactaca ctgagggcaa gcgcaaaggc gagctttcca 3203761 taagaaggat tggtccgtct tactaaggca aaaaagggtt tcaatttact tttagatttt 3203821 tgtttcttgg ttggcatata ttttcctcct gtttcagcgt tcagaaaggt gaaaagtcat 3203881 agcaaaagga tgatttttac tctttctcaa tcatatcaat ggagaaagac tttttcagta 3203941 tatttttgcc gtgatcaaaa taaaaatctc ccactcattg tttgaatagg agatttttgt 3204001 gttagacatc tttcactggc ttcttttttc tgtaagtcaa tgttacatcc tgctgtcgca 3204061 ggtcttctat tatcattttg taccgatcaa cttttgcggt atgttcttct tttatcatct 3204121 gaagggcagc ttttcgtttt tcgctattag actcaagctc tttttttatt ttttttacaa 3204181 tcaacccttt ttgccctttg atttcctctt ttaatgaaga ctcaaatttc tttgtcaggc 3204241 tgagaaagtc gttgatcggt tgattgaggg tgcccgcttt ccccttcatt tcatcttggg 3204301 taagaaacat ataggtcgtt gatacaattt ctgtttcact ttctgaaaat aaggaagtca 3204361 ctcttcatat tcctcctaag actgaaaatc aaataactga gaaatcattt cttctttttc 3204421 aaacagcttt tcaatactct cgcggatatt tttgataaaa tctctttttt ctgttgtctg 3204481 tttttttaat tcagcaacaa ttccatcatt tgcaggaagc gcacctgtgt ggaatgattc 3204541 atgaactgag attttctcca atttatcgaa tgtgtggctg aaaccagctg caagccggaa 3204601 ttgaagatcg aaggcataat gcgaagggtt ttcttccata tgatgaatag ccgtgatgat 3204661 cgcctgcttt ttgtctatga agtcttcatc gatttcctga ctgtaaacct tctggtactt 3204721 agaaatcgca tcttccatat cttcaacgat tttcataccg ttttgataga ttctgacagc 3204781 ggatgagaga ttgacttgaa tcgtttctcc cgagccactc ttccctgtaa aataaatatc 3204841 ggagccttta tagctgaagc ctttttcctt tgacaaggcg ttgagcattt gaacgatgct 3204901 gtggccgtcg acgataagtt ttagtgcgtc ttttgtttct gtgtcgagtg ttttcaatga 3204961 ggacagaatt gattttacat agtccactat ttcaccaacg tcttttaaag cttgcataaa 3205021 ttggccatgt tttagatggt ctatgaaatg ttcgtaccgt gactctatgc ctcgcatact 3205081 cgcattaata ttcgttaatt cttttttgat gactttcttt tgcgtttcat caatataacc 3205141 attttcagct aactgatcta cgaccggtcc gctgtttctc aacaaggtat gaagaaaacc 3205201 taaaaacgac ggcagttcct cttttattcg gccatacatt tgcttaacat catcaaaatg 3205261 ctcatatagg acacttactt tctttaaagc gccgtctgtg tttttcactt tttcaatcag 3205321 gtctatgtct atcccgctgg ctgcctttat aaaaccgttc aagccgtctt tttcatagtc 3205381 atccttatat ttttgaagga atttttgaat tgacctcaca tcttcgtcag gaaccccatc 3205441 cataatgttt cggatgcctt ttacacttgt atttgtatct gccatcttca catcaccgaa 3205501 tgtaataaaa tcggccttgc cgctgactcc atacagcggg tcatcttttg agatgcgctg 3205561 agtgatgttt gttgttacgc ctttgtcttc ataatatttt tggatttctt tttttaactt 3205621 ttctggcggg atggaatcta tatcttcata tttataacta aatttcctaa taacatatct 3205681 atataaactt tcatcagttt caagtaattg atcaatattg acttgagctc catttacccc 3205741 ataaacttca tcatattctc catcaatcaa ttgcaccata acttggttat tatttgcaag 3205801 tgaatgtcct aaggcgaatg tttttaaatc ctcagagtta cctgctgctt tctttgcttt 3205861 gttagtaaac tcctttgtag cctcatactg actatgatca attcctaaaa aaagaccaaa 3205921 aaagttatat gaccaatcct tattatcggc actaccttct gaaataatct gaagctgatc 3205981 aatatgtttt ttctcatcta ttatatggat tgccgttcca tcgtaacctg attctctggt 3206041 cgaactttgt atacttgtat tctgatttac aagttcattg gaggtgtaaa tttcaatttt 3206101 catattctca ggaagatcgt ggtgggtttc ctctttataa attctgcgta tatctgcttc 3206161 gaaatccttc ttagctttct taacttcact cgcaatagtt gaggcaaact tttgtttata 3206221 gtcatattct aaatcaatta accttaactt tacgttctca ttctcaaata catttttatt 3206281 tcccatctta tttctccttt ttatctatta aaaaggtgat agaattaatt aatttctcaa 3206341 ctttattttt agccttttct tcatctaagg agcatggttg attttcattt ttgcatccaa 3206401 gggtaaaggc gtattctact cctaggttat cttcctctgt agacttaaca tatccaaaat 3206461 aactgtatga ataattatat tttctatcaa tatcgtcaaa gatgtctttt ttcttggcag 3206521 tgtaaatatc cgttttcttt ttgctgcttt ttttgtattc gcctttataa tcattttttc 3206581 cactaacaat atctagcatt gtcttaggtt cattcgcaaa actttcttct ttgtaatatg 3206641 ttacatggcc atcaaacatt acattggtgt ctttatcata actattaaat ccaatacttt 3206701 ctttgttttt cccggttaac gatgatcttc ttgatagata ctttccatcc tccggaaaca 3206761 acatcctaaa ccctttcagc ttagattcca gcaaataata tcctggttcc tcttcttttg 3206821 ttgacaccat gtactctctc gttttctcgt cctgaaacgc aggtacttga ggcagatcct 3206881 tgggatccat gtcttttggt tttaccgctt ctgttttatt gtcatttgtg ctgtttttat 3206941 cattgtcatt catactgcat cctcctgtca gggcaagtaa taagctgaag caaataaaga 3207001 tgatcttttt cattacgaac ctccacgggt tttgtgagaa tagtattcta tttttatatc 3207061 aaaaataatt ctattgacct ggttaagaga tgattatttc atcctttttc atgttacatc 3207121 atggcggaat ttggataaat aggaaatgag actcggtttt gatctccttt tattaactaa 3207181 tcatatataa cacccaatat aaatctaaat acctattact tttttcacaa aacaaaaaga 3207241 gccgtatcat ccggctcttt actcttcaat ctcagaatgg cgttttttca atacgtcaag 3207301 cacatcatcc agcggcaggg attgttctct gagcaggaca agcaggtgat acagcaggtc 3207361 tgccgcttcc catttgagtt cctcatgatc ccggtttttc gcggcgatga tgacttcgga 3207421 tgcttcttct ccgacttttt tcaaaatctt atcgacgcct tcacggaaga ggtacgtggt 3207481 gtaagctcct tcaggcattt ccgcttggcg ttccgcgatc acccgctcca gttcgttcat 3207541 gatgccgaat cggtccgcgg cctgttcttc tgtttgttcc tttgtaaaac agctgtagct 3207601 gccagtgtgg catgccgggc ctgacggttc tacgagtacg agcagcgcgt cttgatcgca 3207661 gtcataccgg atacctttga cggcttgcgt gttccctgag gtttctcctt tatgccataa 3207721 cgcttggcgt gagcggctgt aaaaccatgt ttccttcgtt tccagcgttt tttcgtacga 3207781 ttccttgttc atatacgcaa gtgtcagcac ttctttgctt gccgcatcct gcacgatagc 3207841 aggaattaat ccgtcctcgt taaaacgcag ttcatctgcc tgtttcatct cacattcacc 3207901 ccgtactctt tcaagtatga tttcacttct ttaatcgatg tttctttata atgaaaaatt 3207961 gaggcggcca gcgcggcgtc ggcttctcct tttgtaaaag cctcaagcat atgctgtgcg 3208021 tttcccgcgc ctcccgaagc gataacaggg acggggacag cttcggaaac aagctttgtc 3208081 agcgtgtggt cgaaaccttt tttctcaccg tcggagtcca tgcttgtcag caatatttct 3208141 cctgccccgc gtttgacgcc ttcttttgcc cacgcggtga cctcccaatc tgttttcttt 3208201 ctgccgccgt gcgtgtagac cttatatgtg tcagattctt tgtcatactt ggcatcaatg 3208261 gcaagtacga tgcattgaga accgaaaaac tcggctcctt ctgtaatcag ctcagggcgg 3208321 agaacagctg ccgtgttcac cgacactttg tccgctccgg cacgcagtat cgttttcata 3208381 tcgctgagct gattgatgcc gccgccgact gtaaacggaa tggcaagctt cgcggcaacc 3208441 tgctccacaa cgtcaaccat cgtctttcgt ccttcgtgcg aggcggagat atcaagaaaa 3208501 acaagttcat ccgcaccttc ccggtcgtac acttcggcga gttcaactgg gtcaccggca 3208561 tccttcaatt cgagaaattg aattcctttg acaacgcgtc cttctttgac atcaaggcat 3208621 gggataatcc gttttgtgat catttgcgct tcaccctttc aagcgcctca ctcagcgtaa 3208681 actgattggt atacagcgct tttccgatga tcgctccaga gacgccgtcc gcctcattgc 3208741 gggcgagagc ttcgagatcc gcgacggagc tgactccgcc ggaagcgatc accgatttcc 3208801 ccgtttcctt agcaagctcg accgtgcttt taacattggg gcctgacagc attccatctg 3208861 tcgcgatgtc agtaaaaata aagacttccg caccttcatt ggctagctct ttgcccagtt 3208921 cagttgcctt aagggttgat gtttcaagcc atccctctgt tgaaacaaaa ccgtttctcg 3208981 catccagtcc gattgcaatt ttctcgccat attgtttcag catttttttg acaaacggag 3209041 ggttagaaac tgctgagctt cccaggatca cccgctcgac tcctgctgat aaatattcat 3209101 agacgtcatt ttcagaacgg atcccaccgc cgatttcgac tttcaggttc agcttttgcg 3209161 caatctcaat cacatggcgg tcattcactc ttttcccttc tttggccccg tcgagatcaa 3209221 cgagatggat ccattcggca ccctctttct caaataactc agccatgtcg tacggtgaat 3209281 cgccatatat cgtttcctta ttataatccc cttgaacaag gcgaacacat ttgccgtttc 3209341 tcatatcaat tgccggatat aatgtaaaag cactcatttt ttcaccttct gttctgctgc 3209401 cattttcgta aattgggtta aaatagacat tccgaccgtg ctgctttttt ccggatgaaa 3209461 ttgggcgccg aagacgtttc tttttccgac tacagcaggc actcgtacac cataatcggc 3209521 gcttgccaga agcgcgttct cctccatccc gtcaatgtaa taggaatgaa cgaagtaagc 3209581 gtagccttgt tctgttttag tcagcagcgg agattcatta tgaaaagaaa gacgattcca 3209641 gcccatatgc ggaaccttca gcttgtttcc tttttcatct tctgctttca gcctgactgc 3209701 ttttcctttt aacagcccga gtcctgaagc ggtgccgttt tcttcgcttt cttcaaataa 3209761 aagctgcatg ccgaggcaga tcccgagaag cagccttccc tctgagacca tatcgtgaat 3209821 caattgatca agcttcgtgt agcccaaatt gtccatcgcg tctccaaatg aaccgactcc 3209881 cggcaaaatg aaagcatcag cttctttcag ctcctccggc ttttcagaaa caaaatacgg 3209941 cacgccgaca cgttcaagcg cctttgagac actgtataaa ttccccattc cgtaatctat 3210001 cacgccgatc atttacagca tccctttcgt tgacggtatt cctttaactc gcggatcgat 3210061 cgttgtcgct tcatcaagcg cacgtcccag tgctttaaaa acggcttcaa tcatgtggtg 3210121 ggtatttgtt ccataatgaa cgatgacgtg caggttcatt cgagcttcga gcgccagctt 3210181 ccacaaaaat tcatgtacaa gctccgtatc gaaagttccg actttagcag ccgggaaatc 3210241 agcgcgcatt tctaagtgcg gccggttgct taaatcaatc acaacttgag caagtgcctc 3210301 atccatcggc acaaacgccg atccgtagcg tttgattcct tttttatcgc ccaacgcttc 3210361 gagcagcgcc tgccctaagc agatgccgat atcttcagtc gtgtggtgat catctatatc 3210421 aacatcgcct tttgcgttaa tggaaagatc aaattggccg tgtttcgtga ataaatccaa 3210481 catatgtgtc ataaacggca catctgtttt aatatccgct tgtcctccgc cgtctattgt 3210541 aaatgccagc tcaatatctg tttcgtttgt tttcctgacg cgttccgctt ttctcattta 3210601 gaaatcctcc gttctctcgc ttcaattgat ctggcatggg cttctaaccc ttccagtctg 3210661 gcaaaagccg cgatgctttc ggcatgttct tcaaaggctg attgactgta agaaataatg 3210721 ctcgatttct tttgaaaatc agttacgttt aatggacttg aaaatctggc tgttccgttt 3210781 gtcggaagca catggttcgg tccggcaaaa taatcaccga caggctcagg gctgtatctg 3210841 cctaagaaaa ttgcacccgc atgtttgata ctgccaagca aagcttccgg agactgtgtt 3210901 atgatttcta aatgctctgg cgcgagtgta ttgacagtct caatcgcttc taccattgtt 3210961 tccgccacat atatacaacc gtaatctctc actgaagctt ccgctatttc tcttcgcggc 3211021 aaggtttcca gctgcttatt cacctcggct gaaaccgtct cggccagcgc catggaatct 3211081 gtgacaaaca cacatgagct aagcttatcg tgttccgcct gtgacagcag atcggctgca 3211141 atttcgctcg gaatcgctgt ttcatcagcc agcacgacga tttcactcgg tccggcaatc 3211201 atatcgatat cgacatcgcc gaacacttct cgtttggcaa gcgcgacata aatgttgccc 3211261 ggacccgtga ttttatccac cggctcaatg gtttctgttc cgtatgctaa cgccgcaatc 3211321 gcctgagcgc cgcccatttt gtaaatgtct tttatgccca gctcggctgc agcaaccaaa 3211381 actccaggag acagcagacc gtcttttccc ggaggcgtga cgagaacgat tctttcaacg 3211441 cccgctacga gcgccggaat cacattcatc aaaacagatg aaggatatgc ggccgttccc 3211501 cccggcacat atacaccggc ggaatccagc gccgtcactt tctgccccag cattgtgccg 3211561 tcctttctgt gataaaacca ggaggattgc agctgtcttt cgtgatattc cctaatattt 3211621 tcgattgcct gcctaatcac ctgaagaaga cgtgaatcca gtgaggtgta tgcctcctca 3211681 aattcttctt ttgtgaccag cgggctgtct atttcgatgc agtcaaattt cgccgtgtag 3211741 ctgcgaaccg cctgatcacc gtttgcttta acatcttcaa taatggaccg gaccgtcttt 3211801 ctttgctctt ccgttccggc atcgatggaa cgcttgagag aaagccgttc cgctccgctg 3211861 atggttttga tcttcatttt gccgtctctc cttccacaac gagagatagg cgggatgcca 3211921 tttcgtcaat cacatcgtct ttcatgcgat agcttaccgg gttgacaata aagcgagagg 3211981 taatgtcaca aatgtgctcc gtttcaacaa gcccattttc tttcagcgtc tgtcctgtgg 3212041 aaacaatgtc cactatccga tctgcaagcc caatgagcgg agccagttca attgaaccgt 3212101 tgagcttaat aatctcgact tgttctccct gctctctgaa ataactggaa gccacattcg 3212161 gatactttgt cgcgattctt ggcgctactc cgctccagtc tgtattcgga agtccggcga 3212221 cagctaagtg gcatttgctg atgtttaaat ccagtacctc atacacatcg cgttcctcct 3212281 ccagcatgac atccttgccc gcaattccga cgtctgccac gccatgctcc acatacgtgg 3212341 ttacgtccat cggcttcgct aatataaacc gaagattttc ctccggcaca tcgatgatca 3212401 gttttctcga atcttcaaac tcctcaggga gcctgtagcc tgcctgcctc agcagccctg 3212461 ccgcttcttc aaatatccgg ccctttggca tcgccattgt gagtaactta cccattttgc 3212521 tcttcctttc tggcaccgat aaaataagtg acgtttgcaa aagattttgt catctggtcg 3212581 atattttcta ttcccgataa atcttgaaga accactttgt tccctttcat gcgttcttca 3212641 ttcgcataag cgatggcttg cgcccgctgc tctttgctga aaataacagc gtctatttca 3212701 caaggttcgt ccttcatatg aagggcttca atcagccggt cgatccgaag cccgaagcct 3212761 gttgccggtg caggtgaatc aaaatggccc agcagcttgt tgtaacggcc gccgcttcca 3212821 atgacaaaac cgacattctc ggcgtacact tcaaataaaa tccctgtgta atagctcatg 3212881 tggctgacca tattcagatc caggcggaca ttttccgtac atccgtaatc ctcaagaatg 3212941 tcccacagcg ccttcagctc atcaaccacg ctttttcctt gcgcagaatc gacgatttcc 3213001 tcggcacgtc cgcatacttc tataccgccc cgcagttcaa ggagctcaag cagcctgctt 3213061 ttatcaatgg aggaaagcgg gagagacttg acatgctctc tgtagccgac gtagttcttt 3213121 tcatataaga acctccgcag cacatcagct cgttcaacgt ttccgagcac ctcaacaaac 3213181 aaagcatccg caatgccggc atggccaatt gcaattttaa aggatgccag cccagcgttt 3213241 tttaatgccc cgacgactaa agcaatgacc tccgcatccg cgctcgtcgt gccgtcaccg 3213301 attaactcca ctccgacctg ctcgaactca gccggacgtc cgccttcacg ctcctgagcc 3213361 ctgaatacat ttgccgcata gccgactctt agcggatgac cgtgtttcag aagcttcgat 3213421 gccgccaccc ttgcaatcgg ccccgtcata tccgggcgaa gcaccaatgt cttgccgtcc 3213481 tgatcaagta gcttaaacag ctgctgctct tcaattgctg actggacgcc aacggtatcg 3213541 taaaactcca gtgtcggcgt ttccataaat tgatatcccc atttatcaat caaatcggtt 3213601 aacgatcgtc tcaccttttt tttcgtttcg tataaaccgg gcagtgtatc tctcatgccg 3213661 tgcggttttt caaacataaa catcaacccg agcacctccg ctgttatctt atgaaggaaa 3213721 attccgaatc ctttagttcg ctaatatgat aatatgttag cagatgaaag aatgaaaatc 3213781 aacgcttaac ttcagtaagg atatttttag ttcaaatatc cttctcctca ttatgaaaaa 3213841 atcatgaata atgtattaaa ggtacgtaat atctcaaatt ctttatgttt ggcatgctat 3213901 aatacaaatc aaatagagaa caaggagata aagatgaaaa cactgcgaac tctatgtgtc 3213961 ctgatgattc tttcaggcgt tatttttttc ggacttaaaa tagatgcaaa agatatagat 3214021 attccttttt tgaacagcct taaaaaagtg gtttctgata gcgatacaga ctcagctgcg 3214081 aatagcaaaa aggagctgaa gggaagcgca aaaccgctgg atgtcatcct ttacaatcaa 3214141 atggacgcac cccggctcta taacggctgt gaagtaacaa gccttgcgat ggtgctgaat 3214201 tatgcgggat acgacgtgac aaaaaatacc ctggcaaatc aggttgccac agtgcctttg 3214261 acatacagca gcggattaaa gggtgatccg aatgacggat ttgtcgggga tatggcgaat 3214321 ggccctggtc tcggtgtcta ccatcgaccg atctatcagc tggcgaaaac ctatgcggga 3214381 gacaaagtgt ctgatctgac tggaaaaagt atttccgctg tttatcagca gcttgaaaaa 3214441 ggcaatccag tttgggttat tacgacagcc aactttacgc cagttgacaa catgcagaca 3214501 tggaaaacgc caaacggaac gatagaaatt acgtacagcg aacacagcgt cgccgttacg 3214561 ggatatgatg ataaatatgt gtatctcaat gatccgtatg gctataaaaa cagaaaaacc 3214621 gatagaacaa gctttgaaaa agcgtggaaa caaatgggca gccaggccgt ggttattcaa 3214681 aagtaaacac ctgaagcctc actatgctct attctgagca aatacgacaa tattcatgct 3214741 ttttgtatca atcggtaaga tcgattcatt ttccattttt cacccaaaat tgtctttact 3214801 ttcaggctgt ctgtttttat gattaaagca gattcagcct tgccccgatc tatgcgagag 3214861 aagccggtgc aagtcgctga cgcttctctt gcaaaaaatg aaagatatcc ggggaggatt 3214921 tatcattgaa aaaaatcgtg tctatcctat ttatgttcgg tttggttatg ggtttcagcc 3214981 agtttcagcc atcaaccgtt tttgcagctg acaaagtggt gcacgaaaca attatcgtac 3215041 caaaaaatac aacatatgac gggaaaggac agcggtttgt ggcagggaaa gaattaggtg 3215101 acggaagcca gtcagaaaac caagaccctg tttttcgtgt ggaggatgga gcaaccctga 3215161 aaaatgtggt gcttggtgca cctgcagctg atggcgtgca cacttatgga aacgttaaca 3215221 ttcagaatgt gaaatgggaa gatgttggtg aggatgcgtt aacggtgaag aaggaaggaa 3215281 aagtgacgat cgacggcggt tctgctcaaa aagcgtcaga taagatattc caaatcaata 3215341 aagccagtac cttcacagtg aaaaatttca cggcggataa tggcgggaag ttcattagac 3215401 agcttggtgg ttcaaccttc cacgttgatg tgatcatcga caagtgcacc atcacaaaca 3215461 tgaaggaagc gatattccgg acggacagca aaacaagcac ggtcagaatg acaaatacac 3215521 gctactctaa tgtcggtcaa aaatggattg gtgttcagca tatttacgaa aacaacaaca 3215581 ctcaatttta acaaaaaaag tccgctgatg ttattcagcg gactttttca atctttcttg 3215641 catttcttcc ttcgtataga tgatcctcat cggatttccg ccgacaaatg ccccgtcagg 3215701 cacatcctta tggacaagcg ttccggcgga cacaactgcg ccatctccta ttttcacccc 3215761 gggcagaatg gtcgtgttgg caccaatcat cacttcgtcc ccgatcagaa ctttgccgat 3215821 ccggtattcg tgaatcaaat actcatgggc cagaatggtc gtattgtacc cgatgattgt 3215881 atttgttccg actgagatct tttccggaaa catgatatct ggcatcacca tgagggcaaa 3215941 ggatgtctgt tttccaacct tcatccgcag aaatgtgcgg tacagccagt ttttcatccc 3216001 tataaacggc gtatatctcg caatttgaat gacaatgaaa tttttgacga cctttaaaaa 3216061 aggtaccgtt tgatagacat gccacagtga gttggccccc gagaccggat gacgatctgt 3216121 ttttctcaca gattacttca ctccaacgat ttgtaataga tcactcattt tctcaagcat 3216181 aaaatccggc tcatgcttcg ccagcatttc cggcccttta atcgtccatg cgactcctgc 3216241 cgtttttgta ccggcgtttt tccctgccag cacatcatgg taattatcac cgaccataat 3216301 ggcttccgcc ggctcgcttc ctagctgttt cagcgctaac agcacaggct cgggatcagg 3216361 ctttgcattc gtcacatcat caagggtgac aactgtttca aagaattcgc cgattcccgt 3216421 gagcttgagg cccatattga cagtatctct taattttgtt gtcacaattc ctaatgtaaa 3216481 gccggctttt tttaatgcat ccagggtctc atataccgtt tcatattcag tgacgagtga 3216541 atcatgcatg tcatgattgt acgctctgta catagcgatc atatcctcgc atttatcagg 3216601 gtccatcgaa gagaacgtat caaaaagaga cggcccgata aatgcaagga catcttctcg 3216661 tttatacttg ctcggataat aatgctccag tgtatgcaaa aaggacgcga taattaattc 3216721 attcgtatta ataagcgttc cgtctaaatc aaacagaatc gtcgttactt gtttgtcact 3216781 catattgctt cctttccaac cgctgagggt ttccattttt tccacgtgtg cgcaatagcc 3216841 attgtcagca gaactgctgt ggtgacacga atcaaaagaa gcggccagac cggtatgcca 3216901 agcggaataa agacaagtgt atcttccacg accgcgtggc aggcaacgag aaatataaat 3216961 gccaatgtca tgtcccgctt gctcacgccg tcatcctcga cagctttgat catgacaccc 3217021 gctccgtagg ccagaccaat cgtcagtccc gtcaccatcg tcatagacgt atttttattc 3217081 atgccaagca gctgcgtaaa cggcgacagc cacctggaaa accgataaag ccagcctaaa 3217141 tctcttaaaa actggatgat aatcatcagc gggatcacta ttgccgccag ctgcaaaaca 3217201 ccaagtccgg ctttcgttaa tgcttctgcc aacattccta gccagctgtc tggcgccgcg 3217261 ctcttcgcag cgataaaacc gtactgcgcc gtttcctttc cgccatgcca aatgaggttg 3217321 atgacgatgg ctgacacagc ggccaaaccg atgcgcacgg ccaatatgac gccaattctg 3217381 ataccaacct ttgcggcaac tgtcgattcg ataatcaagt tatgacagaa agaaagcata 3217441 acagctaaaa taaagacttc tttcacagat aaatccaatg ttaaaatccc ggcaattccc 3217501 gcatacagat tcagcatatt tcccagtaca agcggaatgg ccgcttcacc agaaagcccg 3217561 aagagaccca ttaccggtgt gatcagccgt acaagccaat ccatgacagg ggtatgctgg 3217621 agcaaagtga ccaatagcgt taccgggaaa atcactttac ccagcgtcca tgttgtttga 3217681 aaacctgctg caagaccggc cagaaagatc ttcttcatcc ctcatccccc tttgttgacg 3217741 tctactccgc gtaccgctcc ttcgagtatc ccttgacgcg tctgaagatg atggctgcca 3217801 cagccaaaac aatcaatacg attgaaatca cctgagcgat gcgaagtgaa tcagtcagca 3217861 ttaagctgtc agtccgcatt ccttcaataa agtatcttcc gattgaatac caaatgatat 3217921 agatcaagaa catctcgcct ctacgcaaat tcgctctgcg cagcagcagt aaaacaatga 3217981 cgccgacaaa gctccatagt gattcatata aaaaagtagg atgataatat tgcccattga 3218041 tatacatttg attgatgata aattcaggca ggtgcaggtt ttctaaaaag gctctgctga 3218101 cagcctcgcc gtgcgcttcc tgattcatga agttccccca gcggccgatc gcctggccga 3218161 gcaaaatgct gggcgcggca atatccgcaa gcttccagaa cgaaaggttt ttcactctcg 3218221 aaaacacata acccgttaaa atggcgccga ttaatccgcc atgaatggca atgccgccct 3218281 tccaaatctt aatgatttct cccggatgtg ccgcataata gtcccattca aaggcaacat 3218341 aataaattcg tgcgcaaata atcgcaattg gaatggcaaa caggacaaga tcaataaacg 3218401 tatctttctg cagcccccgt ttttcacttt ccctcatcgc tatccacagc ccgagcaaag 3218461 cgccgagacc gataatgatt ccgtaccagt ggacggctaa cggccccagc tgaaatgcta 3218521 tcggattgag tggttctatc gcttcattca tttaacgcca actcctattc ttcttgttca 3218581 ccgtcttcaa tgacgtccgc cagcttgttg gtaaattgtt cagcggcatt cagccccatc 3218641 cgcttcaatc tgaagttcat tgctgccact tcgatgatga ctgcaagatt tcggcctggg 3218701 cggacgggaa tcgtcagttt tgtaatttct gtatcaatga ttttcatggt ctcttcctca 3218761 agtccgagcc ggtcgtattg cttgccctgc tcccagagtt caagattcat gacaatcgtg 3218821 attcgtttat tgcttctgac cgcgccagcg ccaaatagcg tcatcacatt gataatgcca 3218881 aggcccctga tctcaagaag gtgctcaatt aattccggag cgtttcccac aagagtatcc 3218941 tgatcctcct gccgtatttc aacgcaatca tcggcaacaa ggcgatgccc tcttttcaca 3219001 agctctagcg ctgtttcgct ttttccgacg ccgctttttc ctgtgatcag cacgccgaca 3219061 ccatatatat cgacaagaac gccatgaatt gctgtggtag gcgccagcct gctctcaagg 3219121 aagttggtta aacggcttga cagtcttgtc gttttcagcg gcgatctgag gacaggcacc 3219181 ccatttttct cggaggcgtc aatcagctcc tgcgggatgg gcatatctct agaaagaata 3219241 atagctggtg ttacatcagt gcacagagaa tccattcgct gctttttctc ctcttcagga 3219301 agctgttcaa agaaagaaag ctctgttttt ccgagaagct gcacgcgctc cctcgggtaa 3219361 tatgtaaaat atccggcaat ttcaatacct ggtcttgata ggtcactcat tgtaatcggg 3219421 cggttaattc cttcttctcc gctgattaat tccaaattga actgttccat tacgtctttt 3219481 gtgcgaacct ttgccacgat atgttcctcc tgttccgggc tgccccgagc ttgctcacaa 3219541 tactttcatt ttatcacttt cgggcttgaa cctaaaacag attttataaa aggggggaaa 3219601 acacctcagc tggtctagat cactagtctg aaaaagagta aaataaaggt attcaaattc 3219661 cagaaaggcg gatcatctat ggcagagagt cttcttatca aagacattgc gatcgtgaca 3219721 gaaaatgaag taatcaaaaa cggctatgtc ggaatcaatg acggaaaaat cagcacagtt 3219781 tcaacagaac ggcccaagga gccatattca aaagagattc aagcacctgc ggattccgtt 3219841 ttgcttcccg gcatgattga cattcatatc cacggcggct atggcgcaga tacaatggat 3219901 gctagctttt ccacgctcga catcatgtcg tcaagactgc ccgaagaagg cacgacgagc 3219961 tttttagcca caacgattac ccaagagcat gggaacattt ctcaagcttt ggtgaacgca 3220021 agagagtgga aagcggctga agagtcctct ttattaggtg cagaactgct cggcattcat 3220081 ttagagggcc cctttgtttc gcctaaaaga gccggagcgc agccaaagga gtggattagg 3220141 ccttcggatg ttgagctttt caaaaagtgg cagcaggagg cgggcggact gatcaaaatt 3220201 gttacacttg cgccggagga ggatcagcat tttgaactga tccgccattt gaaagacgaa 3220261 tcgattatcg catccatggg gcacacggat gccgattccg cattgctgtc ggatgccgca 3220321 aaagcagggg cgagccatat gactcatctg tacaacgcga tgagcccgtt tcatcaccga 3220381 gagcccggag tgatcggaac ggcgctggcc catgatgggt ttgtgacaga gcttatcgcc 3220441 gatggcattc actcccatcc tttagctgca aagcttgctt ttttggcgaa aggcagcagc 3220501 aagctcattt taattaccga ttccatgagg gcaaaaggac tgaaagacgg cgtatatgag 3220561 ttcggcggcc aaagtgtgac ggtaagagga cgaacagcac ttctttcaga cggaaccctt 3220621 gccggttcga tcctcaaaat gaacgaaggc gcacggcata tgcgtgagtt tacaaattgc 3220681 tcttggacgg atatagctaa tataacttct gaaaacgcgg ccaaacagct gggcatcttt 3220741 gaccgaaaag gcagtgtgac tgtgggaaaa gatgcagatt tggtgattgt cagcagtgat 3220801 tgcgaggtga ttctcaccat ttgccgcgga aacattgcat ttatatccaa ggaggctgac 3220861 cagatatgaa agtaatggaa tgtcaaacgt atgaagagct aagccaaata gcagccagaa 3220921 taacggcaga tacaatcaaa gaaaaacctg atgctgttct cggtttagcg acgggcggca 3220981 caccggaagg cacgtatcgc cagctgatcc gcctgcacca aactgagaat ctctcatttc 3221041 aaaacatcac tacagttaat ttggatgagt acgccggact ttcaagcgat gacccgaaca 3221101 gctatcactt ctatatgaac gaccgttttt ttcagcatat cgacagcaag cctagccggc 3221161 attttattcc gaatggaaat gcagacgatt tggaggccga atgcagacgg tatgaacagc 3221221 tagtcgattc cctcggcgac actgacattc agcttctcgg catcggccga aacggacaca 3221281 tcggctttaa cgaaccggga acgtctttca agtcgcgaac tcatgttgtg acattaaatg 3221341 agcaaacccg ccaagcgaat gccagatatt ttccctccat agacagcgtg ccgaaaaaag 3221401 cactgacaat gggaattcaa acgatactct caagcaagcg cattctgctg cttatttctg 3221461 gaaaaagcaa agcggaagct gttcgtaagc tgttagaagg aaacataagc gaagattttc 3221521 ccgcatctgc tttgcacctg cattccgatg ttacggtttt gattgatcgt gaagccgcgt 3221581 cattaagacc ttgaaaggaa catgctgact tatgaatatc aataaacaat cgcctattcc 3221641 gatttactat cagattatgg agcaattaaa aacccaaatt aagaacggag agctgcagcc 3221701 ggatatgcct cttccttctg agcgcgaata tgccgaacaa ttcgggatca gccggatgac 3221761 agttcgccag gcgctttcta atttagttaa tgaaggcttg ctctatcgcc tgaaagggcg 3221821 gggcaccttt gtcagcaagc caaaaatgga acaagcactt caagggctga caagctttac 3221881 cgaggatatg aaaagccgcg ggatgacacc gggcagcagg ctcattgatt atcagcttat 3221941 tgattcaact gaggagctcg cggctatatt aggctgcggg cacccctcct ctatccataa 3222001 aatcactcgg gtgcggctgg caaatgatat tccgatggcg attgagtcct cacatattcc 3222061 gtttgagctt gcgggtgaat tgaacgaatc gcattttcag tcgtcgatct atgatcatat 3222121 tgaaaggtac aacagcatac cgatttcccg tgcaaaacag gagcttgagc caagcgctgc 3222181 caccacggaa gaagcgaata ttcttggtat tcaaaaggga gcgcctgtcc tattaattaa 3222241 acgaacaaca tatctgcaga acggaactgc ttttgagcat gcaaaatccg tatacagagg 3222301 cgaccgttat acatttgtcc actatatgga tcgtctttca taaaaaaagc ctccaaccct 3222361 ttttaaggat tggagacatg gcgaaaatca aactggtctg gtgccggacg atatgtttct 3222421 tttttcgtct tgaacttcca gatcggtgat ttcgttttgc cgttaaaact gtcttccact 3222481 ataatgtacc aataataaac agactgcggt tcaagatgat cccagcggaa ttcagctgtg 3222541 tccccgctct tcacttgctc ccgttttccg agctcttcat tggtatatac gttacattca 3222601 aaataatcgg tttccacctt tttgattctt ggcttcaaat caagcgaaag ggaaaattca 3222661 tccttgttgc cataggtatc cgtatcatag tagttcttat cctttacata cggagagtac 3222721 gtcgatacgt gcaccatgtc attggcttgg tcaaattgaa gcaaacgcaa atacccttgg 3222781 ccgccttctg gcccgccctg ataatcggcc agcatttgat gcacaagacg atccggtttc 3222841 ccatcaccat catcatccag ctcatctgtt tttctcatcg cactatgata atgcccgctc 3222901 aacaccatca cgacattcgg gttcggcttt acgatttctt tgaatatttt ctctccgatt 3222961 gggcttctgt ttccgctgac cagcaaatac tcatgaaaag ctaaaatggc catccggtca 3223021 ggatgcttct tcagcacctg attcatccac gcgatgtctt catccgtaat gccccatccc 3223081 atgtacagca tgatataatc attgccgttg ctagaaatca ggtcataatg tccgcggtta 3223141 tttttatagg aaccgccata atgaaatttt ttatcaaaac gatcgctgcc aaaatatttg 3223201 ccaaacgccc tgtaggagcc gtccttatgt ccgacatcgt gattgccggc cagcacgccg 3223261 taaggaattc cgctcttatc cagaacggac attgaccgat cagcgttttt ccactgtctg 3223321 atatcggcgg aatcatctac aatatcaccc gtgtggaaca catatttgat attgagctgc 3223381 ttttgattat cttttatcca ttcggtctgt ttatcaaaaa tatgcggata gctttcggcg 3223441 taatactgtg tatcagacat ccagacaaat gtgtacatat ccttcgcagg aggaatttca 3223501 tcctgtacaa tcacattcat tttcgactcc cgtacaaaat cggcggcaat cacagacgct 3223561 ttcagcgtaa acggtttgtc atccttcgcg acgaagctgt caacaggctg ccattcgttt 3223621 gtccgataat tccaagcata catcgtcacc tttctccccg gcaaagaact gcccttccag 3223681 actgattctg ccagatcatt ctcatcaatt gatggatcaa ccgtcacttc aaagcgatga 3223741 taagggaaaa gctctttgtt ttctgtcgat actgtttttc catcagcagc tgatacccgc 3223801 tccaattctt tattcgtaaa tggggtctcc ctttccggca caaagctttt cggcggttca 3223861 gtcagtgacg cgtgcttaaa tattttcaca tgattgcgcg ctgtatattg aaatccccta 3223921 taaaaaccaa catccatggc atcattcgtc ggatctttca cccgtacaga aagcttggcc 3223981 ttatgcgtgt cggcttcgct gtctataacc tccggctggt ccggatgctc tcgttcggtt 3224041 ttaaatatcc tctcaatcac tgttttattg cccgcgagat ccgttgctgt cacttttaga 3224101 gaatgttttc ccggcaaaag gtcagaagat gacgtatgat atgggagtgt aatgctttct 3224161 ccatctaacg acgcctccgc ttcctcaatt ctgctccatt tatcatacat atccgcctgc 3224221 aggataaggt ttcctttata cgtttgcccc tcggtgatat tcggctcaat gtgaggtcct 3224281 gaattatcta cccgtacaac caggctgaca ttttccttcc cgtcgcttgc ttgaatatgg 3224341 tgagcgcctt cagaaagctt tgatgtatcc cactccagca gctgtgatgt aaatagtccg 3224401 tcaggcagat tgaactgaaa ttgccagctt ttattcgagc gctgattatc gccaataaag 3224461 agttccttct caggagacac cctctgatct ctgatcaccg ttccatccga taacaccaat 3224521 cgggcgtttt tgactaagaa gtcatcacgg ttttcagccg tatcaaacgg agacaccttc 3224581 gaacctgaac gtatcgtaat acgctgcagc tgcttccctt tccgaagcag tgtctctggc 3224641 aatggaacag aataggtgcg gtatttattt gttgtatcat cgaacacctt cagcactttg 3224701 ccttccatcg ttaccgcgtt tttaaaataa aggttcgttt tcctcgtatc gaatgcaaaa 3224761 tatacttctt tttccatcgc gggctctgtc acttgttttt tcccgtcaat ccatagctta 3224821 atgctgtcag ctcgcccttc tgtcgtggct ttgagaaatt gagttcccga cagcgtgtct 3224881 ctgttttcaa tattcatccg cagaccgtgc gccttgcttg tttgtttaat atcaatcatt 3224941 ttgaccggcg ttctcgcttc attgatcccg tccccggccg ccacataata ctctagctga 3225001 tccttcccga tcaattcagg cgaatacaca atataatgga agagattatc gttgcggtct 3225061 ttttcagcaa gaattcgctt aaacggtttg ttctcatccg tccggtagta aaaggccact 3225121 gttttcacta ggcttcggtc ccgtatgtca gcccgcagct caatgctttc agcagggcgg 3225181 acaggcttgc ggtcagtcaa atcctcaatg accggctttt ctttatcgag cttgattttc 3225241 cgtttctggt cgggcacctg tgcctgtaat acggttccgg gagacggatt cttttccccg 3225301 attgaaatgt tcagaagttc tgctgttccg ttcagtggat acttataaag cactgatgac 3225361 agccggcgca gcgcatgttt ccgataatgc gcaaccgaaa tgtcctttcc tgtattcgtt 3225421 gatatcacaa cggcccgcgg cctcgtattg gccataccct ctgtctcgtc tatcaccgca 3225481 agattttttc cttcttttag ttgtgtctga taataacgat tgaaatccgc tgacgtcaat 3225541 tctggatgcc cggcaggctt cagccagacg acaaacgttt cgccggatgg tatcaagatc 3225601 ctttcatcag gtctccaaat cagatcggag tcaggccctt cttttgggta gcggtaacgg 3225661 atatggtagt ctttaaaatc aatcgttctg tcagtcgtat taaaaatctc aataaattca 3225721 taaccgtctg cgcgtcctat attcttcgta tcaaccgcca gctctgtgat cagaagctcc 3225781 ggaatatggg caaggtcagc ctggtatcct tcaagcttca gtttcttcgt ctccgactca 3225841 acccgctgct tcccattcga catcacaatg taatactcaa gctcgctgtt ccaaatcaaa 3225901 cgtttcggaa tttgtgccaa aaacttgcgg accgctccgg gggtcgggtc catcggcacc 3225961 attttgtagc ccagctcatt actttgttta taaaaaagaa aggcggaaaa tgcttgatac 3226021 gaattatcgc gaacttgagc ctcaatcatt agattgcttc tcatttcagc tttcacatca 3226081 atttgaggag gattttcaag caagggtatg taatgaggcg tttgaaatag ttcctgctgt 3226141 acaacaggaa aagctttcga ttcatgatgg ccgccagaca aaacggaaag aaaagacagt 3226201 aatatagaag caataaccgt gtatttcctc atcaaagcac ctcccttttc atgtattttg 3226261 cgtctgaaca gggaagctta tgagttcatt tttgtgcata aagaacaaaa aaacgtctgt 3226321 ctcttgaaaa ttccactatt acccagtaaa ctaaggatag ttaaccagtt aacaattaaa 3226381 tcagagaggc aaattgatgg acaacagcat tcatgatgaa ttatttcaag ctatacaaca 3226441 attcgcatta aaaagggata aacgcgtctg gcaaaaggtg cagataccat ccattggcat 3226501 atcctcacaa catcacgatc acctcaaaaa agactggact ttgacccagc ttcacattgt 3226561 ttcctgcata cataccagcc aaaatgtgaa caacagcttc ttagcatccc gtttacacat 3226621 ctcaaaagcc gctgtttcaa aagcggttca tgctttgttg aaacacaata tcattacagt 3226681 gacaaaaaag cctggcaaca aaaaagaaat tttttatacg ctaactgata gcggcagaaa 3226741 attggcggca ttacatgaac agcttcatga gaaagcaaag gagcaatata aacagctttt 3226801 caatgaattt tcaattgatg atttaaaaac agtgactgcg tttttcaact tgtggatcaa 3226861 atatatgtaa aaagagtctc acccgcatgg gagagacctt tggaattcta ttatgccccg 3226921 tcaaacgcaa cgagaagtga aacaggtccg cgtgtataca gaccggactc agcataacaa 3226981 aaatcttcct ctaatctgat attccgcatc ttatccagca caatattagc tacaatttcg 3227041 atttcgtttt tggcaaaagc tgctcctaca cagttatgaa tgccggatcc gaaagcgaga 3227101 tgccgggcgg cgccgctaaa agcgctcttg ataccaagat cttcccgatg aatattaaac 3227161 acgtcaggct gttcaaatgc ttcagggtcc cggttagccg caccgatcat acaaaaaaca 3227221 atcgtatctt ttttgatttc cataccgccg accactgtat cttgggacag ctgccgcgga 3227281 atcagctgaa ccggcggttt ataacgcaat gtctccgcaa tggctctcgg aactaacgaa 3227341 cggtcagcca aaacatcatt catctgctca ggattgttga gcaaatggta gatcatcagt 3227401 gccagcgtct tatcagccgg ttccgttgcg gctaacagca cattaagaat cagtgcgagt 3227461 atatccttgt ccgacagcgc catgccttca tattcagaag tacataggat cgaaattaaa 3227521 tctgatcccg gattgacgcg acgttcttta atgaccggca tcaagtattg ggaaagctgt 3227581 tcgctgcacc ataacgaatg tgcccgcgct tcaggagatt gagagatact cgtgataaaa 3227641 tcggcaactc cgctgtgcca ctcagagatt ttttcatggt ctcttttatc cagcccgagc 3227701 atgtccatcg tgacgcacac cgcaaacgtc tttccaaaat cattgacgag atcacttttc 3227761 cctctttcaa gataaggcgc taacaagttt tctgcatttt gtttaatcaa tggagacaga 3227821 tgatccagtg cgtcaccgat aaagcttctc actacaattc ttcttttggc agagtgttct 3227881 tttccatgca tttgggccag cacagggcct cgcatgactg gttcggcacg ctcaacaagt 3227941 gatttcgtcg tgaagatatc cggatgctga aggatatagc ggacatcatg atagcggctg 3228001 ataaaataac tgtctatcga ctcttcataa tgaaccggat cttcctcccg cagttgtgaa 3228061 aaataagcat atggattgtt ttgaaattga tcagaaagca cactaaacaa tttaatcgat 3228121 tggctcatgt tttactcccc ctatcatcct tcagatgtga tccgtttctc agaaagcatc 3228181 tgcgccattt cctgtacaat gagataccct tgattcggcc gcatacaaat agaaaattca 3228241 tggttactga tcttctcacc cagcttccac ggacgatgat aagcaaggag tgtctcttcc 3228301 acctctaaaa tatccggagc tccgataaaa aacggcagct cagctatgac atattccaca 3228361 gccaaattca gcatatcctc actgacttct tccatcatca aactgacgcc ccgcgcacgc 3228421 ccgattatcg cttcacgaga catgtccaaa caagcatgtc gaaaatgagg ctgctcaaaa 3228481 aatgcatgtt caacttcttg tctcaacagc tggtaggctt tgttatctat aaaatcagaa 3228541 aatgtatgaa tcgccttcgg atccccgcca tgagccacaa gggctctttc tgcaaatctc 3228601 ctgtttcgtg atacctcttt ccttactttt cgttcagcct ttcctctcgg agttccaagc 3228661 gcttctagaa gattagccgc ctcatgccct gcaagtaaaa ctgaaacgct tttaaattga 3228721 gctttcgccc atccaattaa tctgtaaata taatcctctg aaaacctgct gttaaatggg 3228781 ctgatcccca ccaaaacatg cctgcgccgt tcaaatattt ctctgcagtt ttctgttaat 3228841 gcctcagcaa taaaatgcac agaccttctt tccgttacca ttccggtcat ctcattcacc 3228901 cctaaaactt atcccgcttt aagtcatcac cctcaaatac aagatggaat agctagaaca 3228961 actgaacaag acgaatggca ggcatcactt aaagtttcca aatgtttttt aagattttaa 3229021 taatcatttt caatacccat atcatgataa atgtttacta gtaaacatta gtcattttat 3229081 cccttttcct tccaaacgtc aatatgatct gtgcccaaat atttgaaaat aaatgtaaac 3229141 atcacatttt ccacacactt tttacacgca tattcagcat gacatatcaa caaatagtct 3229201 aaacaccaac aattgacaac gaaaacaaga aaagataaaa taaaattgtt caccagtaaa 3229261 cgatttgttt tattgtttca tcgtaaacta ttattcctaa gaaagaaggt agcctatgtc 3229321 tgatttgaca aaacagatga tatacgacat atacgtgaga ctgctgcacc ttaatgaaca 3229381 aaaagcgaac acttcacttc agcaattttt taaggaggcc gcagaagagg atgtagctga 3229441 aattcccaaa aatatgacaa gcattcacgt cattgactgc atcggccagc atgaacccat 3229501 taataatgcc ggaattgcca gaaaaatgaa cttatcgaaa gcgaatgtaa cgaaaatcag 3229561 cacaaaactg atcaaggaag aattcattaa cagctatcag ctgacagata acaaaaaaga 3229621 agtttatttt aaattaaccc gtaaaggcag acggattttc gacttacatg agaaactgca 3229681 taaaaaaaag gagctggctt tttaccaatt cctcgattca ttttcacaag aagaacaaaa 3229741 ggctgtattg aagtttctag agcagttgac gtcaacactt gaagcagaac aaaccgatgg 3229801 gactccagac aaacctgtaa agtaaacaaa aaggcggtgt acactttggc tcatacaaaa 3229861 tcaaaggcag tattgatctt atacactgtt tgcttcagtg cattttttgc atctttaagc 3229921 cagaacattt attcacctat tcttccgatc attaaagaat cattccatgt ttccacagct 3229981 atggtgaacc tgtcagtctc agtttttatg attgtgacag caataatgca aattatatta 3230041 ggagcgatca ttgattttaa aggcgctcgg atcgtcttga ttaccggtat tctggcaacg 3230101 gcagcagcca gcatcggctg tgcggtgact actgacttta ccttgtttct gatattcaga 3230161 atgatacagg cagccggttc cgcagcactg cctcttattg ctgccacaac gatcggacag 3230221 ctgtttacag gaaatgaacg cgggagtgca atgggaacgt atcaaatgct cctgtctgtc 3230281 gcaccggcta ttgctccagt tctaggagga ttcataggcg gagcagccgg atacgaaggg 3230341 attttttgga tacttgcggc catctctatc gttttgctgg tgacaaacag catcaccttt 3230401 cctaaagatt ctccaactga atctatgcag caagccaaag gcaatgtgtt cgctcattat 3230461 aaatcaatat ttacaaatcg aacagggaac gtcattttga ctttaagttt tgttctcttt 3230521 ttcatttatt ttgcagtaat tgtctacctc ccaatattgc tgacagagca ttaccatata 3230581 gatgtgggta tagcaggact gttatatttg ccgctggcgc tgagcacgat tgcaggtacg 3230641 tttctgttta aaagaataca ggcaaaaatc gggctgcaca ccttgtttat cggaagcaat 3230701 gtgattgccg cctgcagcat cattttattt gctgttacac attccgtttc tctcgttctc 3230761 atggctctga cgctggcact gtttggcatc tcgatggggg ttattcctcc cttgtactct 3230821 acaatgatta ctaatgaatt tgagcacaac agagggagtg caatcggaat gtttaacttt 3230881 atccgatata caggcatggc agcaggtccg atggtatctg cctacttgct cacaatgatg 3230941 ccgtctgcca tgtcctttag cctcctaggc cttggatttg ccgcattgag cttttgcctt 3231001 cttccgccaa tgttttcgcc gcagaagcgc acgaaacaaa aaaagcacca catgtaaaaa 3231061 agctgccttt gcgggcagct ttttttattt ttttctaagc ggctctaaaa tgcctttttg 3231121 aatcagcaaa tggaagaccg acaggataac ggatgcccat atcgctgtgc cgaagccgtc 3231181 gatttgaaag ctgtcaccca taatggacgc ggtcatcata agcgtgatgg cgttaatcac 3231241 aaacaagaag agtccaagcg tcaccatggt gaccggcagt gtaaatataa ttaaaagcgg 3231301 tttaatcagc acgtttaaga tcgataaaat gaggctggcg ataatcgctg ccccaatgct 3231361 gctgatatgg atggagtcaa tatatccatc aatgacgatt aataacaatg cattgactaa 3231421 aatgctgact gcccatttta ccatgtcatt tcatatccct ttctgacggg acgataaaaa 3231481 tccaaatgat ataaatgagc aaaaccggca agacacttgt cataatggct aagatgacag 3231541 ttatgactct gaggagtgat gcgtcccaat tgaaatattc cgcgagacct ccgataacac 3231601 cggcgatttt cttatttttt tctgagcgat aaagcttatt cattcgatca cctctgtgag 3231661 tactttagtt tgatggcgcc tgttagtgat tctgagaaga cggtgatgtt ttgatcatgt 3231721 gcctgatttg aagtgaacat catttctttt tgaatcgtat catttttttc cttcagcatc 3231781 tctacatcca ttaattcatg ggacagcgta ccaagattgc ttttcagctc tgccttcact 3231841 gcgagatcgt ccggaattgc aagctctaca tttccagtcg ttgtttttgc ataaatggag 3231901 cggcagtctg attctgttac gttaatcgca atatttccgt taaagctttg aacgtcaatg 3231961 gattcgcttt tccctcggag atcgatcaat ccgttaatgg tttccgcttc tatcgtaccg 3232021 cagctgtggc ttgcgagctt aatttgcccg ttggccgttt cagctatggc tttttcggct 3232081 gttaaatacg agaacgacag cacgccgttt gtcgttttcg ctgagaactc ttttacatgt 3232141 aaatgttccc ctctgactgg accgttaaac agcttcaccc gaatcttatc atactccttc 3232201 tgaggaatat acaaagtgac attcgttttc atcgtctttt tctcagtacg gataaaaaac 3232261 ttattacctt tgatttcaca ttcaatatgc tgaagaaatg cgtgtctcgc cgcatcctgg 3232321 ctgtcagcgc gatatacctt cgcctggcat tccgctctga tatcgtcatc ttcccaaggg 3232381 acgatattta cgctgccatt ggcaatttgc agctcaacac tggaaaagtc agtatcttta 3232441 aattgaaaaa tgtgctgaac atcatacgca tggccaaagt ttaaatcaag gtcaacttcc 3232501 ttgacctttt tcacagcaga atcaatccag tcaaacagct tggctcctaa agacggtttg 3232561 ccgctttctt tttttgccgt tgtaaatggc tcttcctcgt catgaacgtg aactgagagc 3232621 gctgtgattt tctcttcttt ttccttgtag tcgctgtcaa gcttttcaat cagtgtcaaa 3232681 gcttcttgtg ctgtaagctt tccttcctca acaagcttaa ggattcgttc cttttcttgc 3232741 ttcattacga tctcctcccc attgtctact tatgctgcac gcaggacctt aatgccctga 3232801 atcacattcc aaatgataat gccaatgaca actaagaaat aaataaccgc tcccccgatg 3232861 attacaaata caggaagcaa gctgtctcca tcaatcgcaa cggctccgcc aagtaaagca 3232921 ataaaaagga acagccagcc gacaaacgga acaatgtgag aaataagaga gcgtatcgca 3232981 tggcgttttg tttctttctc atttacaaca aaatatgcga caatcggcac aatgattggc 3233041 gcaatgaaca cactgaaata acaaagtgat gcaataatag cttgattacg gttcaattca 3233101 ttccacactc ctattgtgaa ttgtccatga caaaagatca gggacgtttt acttatttat 3233161 acgtttaaaa tctcttcagg tttcaaattc attctttaga catgctccga tttacggaaa 3233221 ttggatttta aaaagtttta gaagtagaat cttccggcta taccgattac aatatgtaaa 3233281 aagcttacgg caaccaagga ggctggacaa gcaatggaga aagatcccag tgactataca 3233341 gtaacacaag aatcagtgtt aaagctgatt caggaacaaa aaagaatgaa tcgtgaaatg 3233401 atcaccgagc ttgagcagat tcacggaccc ttcccgatct ctcacgatat ccaatatata 3233461 aaagtgctgc tcgacagcag caacacacat attgttcaag atttaatgag tgtaagtaag 3233521 cagctgtata agaagacttt gtaattgcgg aaaacatatc attcattata actgaaacaa 3233581 agctaaaggt tagatgacaa tatcttgcct tttttgtttt gaaaaaacaa gtgattccct 3233641 ggctgtcaca aaatgattgt aacaaaaaaa gcctgccggc acatccagtt aatggactct 3233701 gtcggcaagc tgtaactatc agaaagagat agccgttcaa aattaacgta acaattgaag 3233761 cacgttttgc ggctgttggt ttgcttgagc aagcatcgct tgagaagctt gagaaggaat 3233821 gttgttcttt gtgaactcgc tcatttcttt cgccatgtca acgtcacgga tacgggactc 3233881 agcagctgtc aggttttcag aagaagcacc aaggttgttg attgtgtgct ctagacggtt 3233941 ttgtaccgca ccaagtttag cacgttggtt tgagacattg ttgattgcag tatcaatact 3234001 ttcaagttgt gtatcaaaag gagtattagc aaaatctgtt acattaagtg cgtttactcc 3234061 taaagcagtt gatgacatgc tgtcaatgtt aactgtaagc tgctggccag catttgctcc 3234121 aatttggaaa gtgaaaccat cagtttcagt accatctaat aactttttgc cgttgaattc 3234181 agtacgattt gaaatgccat caacttcctc aataagcgca tccatttcat ctttaattgc 3234241 accaagatct tctgcttgtt gtgtacctgt gtttcctgct tgaacagtaa gttcacttct 3234301 aaacctatta tgccgtaaag aaaaagcttg cctgctaagc ccaaggatgg acttgccgac 3234361 aagctgtccc ctcttaacag agggttttaa gatgtagctg tttcttttgc tttcaagagc 3234421 gatttcatgc gtgttttgtc acgttcgata acaggcttta aataacggcc tgtatacgat 3234481 tcttcaactt cagtgatttc ctcaggcgtt ccagacgcga caatggttcc gcctccggct 3234541 ccgccttccg ggcccaaatc cacaatgtaa tcggccgtct taatgatatc aagattgtgc 3234601 tcaataacca gtacagtgtc tccgttgtct accaaccgtt gcagcacgac aagaagcctg 3234661 gcgatatcgt cgacatgcaa acctgtcgtc ggctcatcta aaatgtagag cgtacgtccg 3234721 gttgagcgtt tgtgcagctc tgacgcgagc ttcacgcgct gcgcttctcc gcctgacaag 3234781 gtcgtcgccg gctggccgag cgtaatataa cctaaaccaa catcataaag ggtttggagc 3234841 ttgcgtttga ttttcgggat attttcaaag aaagaaagag catcttcaac cgtcatatca 3234901 agcacatcag agatgctttt tcctttgtac gtcacttcaa gcgtttcacg gttatagcgt 3234961 ttgccgtgac acacctcgca tggaacgtat acgtcaggaa ggaagtgcat ttcaatttta 3235021 ataatcccgt ctccgcggca ggcttcacat cgtccgccct tcacgttgaa gctgaaacgg 3235081 ccttttttat agccgcggac cttcgcttca tttgtctgcg cgaatacatc acgaatgtca 3235141 tcaaatacac cggtgtatgt cgcagggttg gatctcggcg ttcttccgat tggcgcctgg 3235201 tcaatgtcaa tgactttatc taaatgatcc aaacctttaa tctctttatg gctgccgggc 3235261 ttcgctttcg ctttatgaag cttttgcgcc agcgccttat gcaaaatttc attaacgagt 3235321 gtactctttc ctgaaccgga aacacctgta actgctgtaa acgtcccaag cgggaacttg 3235381 gcattcactt ttttcaggtt gttttctgat gcacctttaa tttcaatgta acgtccgtcc 3235441 ggctttcttc tttcaggagg caatgggata aactttttcc ctgataaata gctgcccgtt 3235501 aatgaatttg gatcttccat cacttcttcc ggcgtacccg cagatatcac ctgtccgccg 3235561 tgaatgccgg ctcccggtcc aatatctatt aaataatctg ctgccatcat cgtgtcctca 3235621 tcatgttcga caacaatcag cgtgttcccg aggtctctca tatttttcag agcgctgatc 3235681 aagcggtcgt tatcacgctg atgcagaccg atagacggct catctaaaat ataaagcaca 3235741 ccggataaac gcgagccaat ttgagtcgcc agcctgatgc gctgcgcctc tcctccggac 3235801 aatgtacccg ctgccctgct caatgtcagg taatcgaggc cgactttgtc cagaaagctt 3235861 aagcgctcca caatttcgcg caaaatcaaa ttggcgatct gcatatcctt ctcagaaagg 3235921 gtaagatctt taaagaaggc aagtgcgtcg gcgacagaca gctcggtaat tttcccaatg 3235981 tggcggccgt caatcagtac ggcaagcgcc tctttcttta accgatagcc tttgcacgtc 3236041 ggacaagact tctgagacat atactgctcc atttgctcac gtatgaaatc ggagcctgtc 3236101 tccttatagc gtctttcaat gttgcgcaat acgccttcaa attgaatttc accttcgcgg 3236161 atttgtccaa aatcattttc atatcggaaa taaatcaggt catccccgct gccgtacagc 3236221 actttatcca gttgatgctt cggcaaatct ttgaccggca catccatatc aatcccgtag 3236281 tgggtgcaga ctgcctcaag cagctgagga taatattgtg agctgatcgg tgtccaaggg 3236341 gcgaccgcat tctccttcaa tgacaaatct tgattgggga tgacaagatc ggcatccact 3236401 tcaagcttca ttccgagacc gtcacacgtc ggacacgccc cgaacggact gttaaacgaa 3236461 aacagacgcg gctcaagctc accaattgaa aatccgcagt gcggacaggc atgatgctcg 3236521 ctgaacatca gctcttcctc accgatgaca tcgatcataa cccgtccttc acctaaacga 3236581 agcgccgttt ccaatgaatc tgacagccgg gctgccacgc cttctttcac gacaatccgg 3236641 tcaatgacta cctcaatgga atgcttcttg ttcttttcta attcgatatc gtcggaaagc 3236701 tcagccatct cgccgtcaat tctgactctg acatagcctt gtttcctaat ctgttcaagc 3236761 actttgacat gagcgccttt tcggcccgag acaatcggcg ccagcacctg aagcttcgtc 3236821 cgttccgggt attccagaat tctgtccacc atttgctcga tggtctggga tgtaatctca 3236881 attccgtgtt ccggacaatg aggcttccct actctcgcat ataaaagacg cagataatca 3236941 taaatctcag ttaccgtacc gacagtagac ctcggattgc ggctcgttgt tttctgatca 3237001 atgctgatgg cgggagagag cccctcaatt gcatccacat ccggcttatc catttgccct 3237061 aaaaactggc gggcataggc agacagcgac tcgacatacc gtctctgtcc ttcagcatat 3237121 atcgtgtcaa aggcaaggga ggatttacct gatccggaca aacccgtgac aacgacaagc 3237181 tgatctctcg gaatcgttac atctatattt ttcaggttat gcgccctggc tcccttcacc 3237241 tctatccgat ccatagccat ttgttcatca tccttccgct tttagctcta aaagtaaatc 3237301 gcgaagctcc gcggctctct caaagtcaag cgccttggcg gcttccttca tttcatgctc 3237361 catctgttca acgactttct ggcgttcttt cttcgtcatt ttcgacagct tcggcgcggc 3237421 ttttgttttg tattccgctt tatcctcagc tgctactgtg gcacgaatga catcgcgaat 3237481 ttctttattt atcgttttcg gcgtaatgcc gtgctcttcg ttaaaccgct cctgctgctc 3237541 gcggcggcgt tttgtttcat taatcgcaat ttccatagac ttcgttattt tatcggcgta 3237601 cataatgacg cggccttccg catttctcgc tgcccgtccg atggtctgga tcagcgaccg 3237661 ctccgaacga aggaaacctt ccttatccgc atccaaaatc gcaacaaggg atacttcggg 3237721 aatgtccaaa ccttccctca gcaggttgat gccgacaagc acatcgtact tgccaaggcg 3237781 caggtcgcgg ataatttcaa tccgttcaag cgtcttgatc tcagaatgca gatagtttac 3237841 tttaatgccg atttccttta aataatcggt cagatcctct gacatcttct tcgtcaaagt 3237901 tgtcacaagc acccgttcat tccgctcgat tcttgcttga atttcgccga tcaagtcgtc 3237961 aatctgacct tcgattggac ggacgtcaat aagcgggtca agaagccccg tcggacgaat 3238021 gatctgttcg accatttcat ctgtatgttc aatctcgtac ggccctggtg ttgctgatac 3238081 atacacgata ttgtgcatat gcttttcaaa ttcctcaaaa cgaagcggac ggttatcaag 3238141 cgctgatgga agccggaagc cgtgatccac gagcacctgt ttccgcgcct ggtctccgtt 3238201 aaacatgccg cgcacctgag gaattgtcac atgcgactca tccaccacga tcataaaatc 3238261 gtctgggaaa taatcaagaa gcgtatacgg cgttgaacct ggaggccgca gagtcaaatg 3238321 tcttgaatag ttctcgatgc cggagcagaa acccatttca cgcatcattt caagatcata 3238381 tcttgtccgc tgctctaaac gctgcgcttc aaggagcttt ccgttttcat gcatgacctt 3238441 cagctgctcc tcaagctcct tctcgatatt ttgaatcgcc ttctccattt tctcggcccg 3238501 cgttacgaag tgggatgccg ggaaaatcgc aacatgatct cggtcgccga gaatttctcc 3238561 tgtcagcgca tctacttccc gaatccgttc gatttcgtca ccgaaaaatt caactctgac 3238621 acaatgctca tcacgggatg ccggaaagat ttccactaca tccccgcgca cacgaaatgt 3238681 accgcgctga aagtcgatat cgttgcgggc atattggatg tctacaagtt ttctgagcag 3238741 ctcgttgcgc tcaatttcca tttcagtccg cagtgacacg accatttccc ggtattcctc 3238801 aggcgaaccg aggccgtata tacaagacac actcgcaata ataatgacat ctctgcgctc 3238861 aaacaaagct gatgtggcgg agtgtctcag tttatcaatt tcatcattaa tactagcgtc 3238921 tttctctata aatgtatccg tttgaggcac atacgcctcc ggctgataat aatcatagta 3238981 gctgacaaaa tactcgacag cattgttcgg aaaaaattcc ttgaactcac tgtaaagctg 3239041 tccagcaagg gttttgttat gggcaatcac gagagtcggc ttattgactt ctttaatcaa 3239101 attggacacc gtaaatgttt tcccagttcc tgttgcaccc agcagagtct gatgcttctt 3239161 gccctcctga attcctttca caagcttttc aatggctttc ggctgatctc cctggggctg 3239221 atatttcgag actaactcaa agcgatcttt cacaaaaata agcctccgtt tctttaacga 3239281 aatcttccta tagatatagt aacacaatgg aaagcaaaat cactaaaaat acgaactaaa 3239341 gttcggtggt tttttatttc cagctgtttt tgtgtataaa aaacctgctt ttaaaacgta 3239401 aaagcaggta ttcagtcttt atattcatta tgtccgattt attcttcttt tttctctgca 3239461 gcttttttgg ccatatacag tccgccagcc acaagagaca caacatccaa tcctacaata 3239521 aaatacgttt ctgtatagcc ttttaaataa gaggcaaaca gcaatgcagc tgttaaagcg 3239581 atcgccacat aatgattaaa ggtgactcta gtaaatagaa caacaagcat aaaagggaaa 3239641 aacaatgcaa aaacggcttt tgtaatcaac aaaaaccctc ctcagggatt cttcatctga 3239701 tctgattata gtaaaaaatg aagaatcgga caatcgtgca ttcgctccct ctacttacac 3239761 catacccctt ttcagccaaa atcaatcacc atatttgcat tttggtgccg gtcaaaactt 3239821 attccatggt gccgctgttc taatcagcgg cacttttttt attacatcat caagtccgcc 3239881 gccagattcc gagaataaaa gaaaataggc atacagtacc agtacggccg catttttcag 3239941 gataatataa ccaacttaac tattcatttt atttaggact ttctgcgttt gacagcattt 3240001 tcctgaaaac ctacaattaa atgatagtgt ttactatcat tttttaaaca caggctccgc 3240061 aataaaaaga ctagagagaa aaacaaaatg aatgaagaaa agaggggttt caaatatgta 3240121 ttctgtttta tttcgccagg cagaagagtc cagccagctg gctggagcaa aaggaatgaa 3240181 tttgattaaa ttgaccaaac acggtcttcc tgttccggac gggtttatta ttcaaacgaa 3240241 tgcgctcgca cgttttatgg aggacaacca gcttcaagag actagtgaaa acgtcgaagg 3240301 cgggatcatt tccggaacat tttcggatga gctgaaagat gagctgacta gttcctttta 3240361 taagcttaga gaatcatatc gatccgtagc cgtgcgttct tcgtctgctt cggaagattt 3240421 agaaggcgcc tcattcgcgg gtcaatatga aacctactta aatatcaaaa cagaggaaga 3240481 gtttctggct aaagtgaaag aatgctgggc ctcatttttt tctgggcggg tcagcagcta 3240541 taagaaaaaa atgaacaatc aaatcgcaga gccgttaatg ggaatagtcg ttcaggggct 3240601 gatcgattca gaaatgtcag gtgttatctt cagccgcaac cctgttaccc atgatgatag 3240661 agagctttta atcagcgcca gctacgggtt gggtgaagct gttgtttcag gaaatgttac 3240721 cccagacacg ttcattgtta ataaatcttc gtttgagatt cagaaagaaa taggtgcaaa 3240781 ggaaatctac atggagtctg cggcagaagg aattgctgaa aaagaaacga gtgaagacat 3240841 gcgcagccgt ttttgcctta cagatgaaca agtgattgaa ttggctgaaa tcacaaaaaa 3240901 aaccgaagac ctgtacggat atcctgttga tatagaattt ggaattgctg atcatcaaat 3240961 ataccttctg caagctcgcc cgattacaac cattgatcag gacaaaaaag cggcagaaga 3241021 aaaacgcagc ttcatgatta ccgacactga tatgaatgat ttctggctta acatggagtc 3241081 taatattgaa ggtccggtga gtccgttatt ttcatccttc atcgtgccgg cattggaata 3241141 tggcttgaag aagagcatgc aaaagtttcc gattggtgta gttgttgatg aagtaaaact 3241201 ttatcgcgga catatttatt ccaaaaacca aggcggacag cagcctcctt ctgaagactg 3241261 cggcaaagag cttttcccga ttttatcgga gcatatgtat gacatcatca atcacacata 3241321 cctccctttt taccggacac tggaccagct cgcacaaact gagcataccg cagaaagcgc 3241381 actggaagct tttcaaaaac taaaggcctt ttatctcacg gcttatgaag agcactttaa 3241441 tatcgttttc ccgcaaatcc ttttaacaaa caaactgcaa gcgatgtatc aggacattca 3241501 aggagagtcc gaaaacgctc atttttacga gatgctgaca ggaaaaatga acaaatcact 3241561 ggaaacggac cgttgcttat ggctattttc tgtggaagtt caggagaacc cgaaccttct 3241621 ggccattttt gaaaacaaca agcctgaaca gctccaggag aaattggaac aaacagatga 3241681 gggaagacac ttcctgaaga acgtccatga attcttgcaa gaatacggat ggagatctgt 3241741 taaaagtcat gatctgattg aacaaatctg ggtggaaaat ccgtatttcg ctctggccaa 3241801 tattcaaaat tatgtccgta atggctatca ttttgacaat gaatttcaga aaacaaaaga 3241861 aaaacgagag aaattataca atgaattctt ggaaagcata gaagatcccg gtttacgcac 3241921 cgaatttgac cgctattatc aatggacact gaactctgca aatataaaag atgatcacca 3241981 cttttatatt gacgccatgc tggatgccaa ggcgagaatc tttctgctga agataggtga 3242041 attgctggcg gaaaacggtg tcattcaaga tcgggaggac ctttggttct tatatgacga 3242101 cgaagtggaa caagcgcttc ttcaccctgt atccctgcaa gaaaaggctg aaaaacgcag 3242161 acagattttt catgagtatg agctggccca agccccggcc tacctcggca ccccgacaaa 3242221 agaacagctc aaagcagctg aagaaattgt cggcgctgtg atagaggatg aaaaaaacac 3242281 agagaatcat atttttggca ttgcggcatc aagcggcatt gcgacaggtc cggtgaaaat 3242341 cattcgggac gccaatgaat tttctcaatt cgcgcctgga gacgtactcg tttgcaagat 3242401 gaccacaccg ctatggacca gcctgtttca agacgccaaa gcgattatta cagacacagg 3242461 cggcattttg tctcacgctg cgattattgc ccgtgaatac ggcattccag ccgttctcgg 3242521 cacacgcacg gcaaccgaaa gactgcgaga cggtgacatc atcactgttg acggaagcag 3242581 cggcaaaatc acagttgtca gccggtcctg atgcgtcccc ctctttctta tacaagcggg 3242641 gcgggtgtat acttgtcctg ccagtatatt cgtgaggtga aacgtattga gaccgacaaa 3242701 caagagaatc cttgatgctg ccatgcagct gctcgtcaaa aaaggatatc gcgcaacgac 3242761 tacaaaagaa attgcagaaa aagcaaatgt aagtgaagcg acgattttca ggaactttaa 3242821 aaacaaacaa ggactagttg aggctttgct ttctcagcat tcttcaaaca gaggcagcat 3242881 tttggaacaa acagaagggg atttgtacaa agacctgctt catatcggaa cctgtctctt 3242941 ggaggagctc gaacatagaa aagatatcat taaaatcagc tttcgtgaac cggccatgtt 3243001 tcaggatgtc attaaccacg tcactgaata tccccaatct atgaaacagc tattggttga 3243061 ttatctcaaa acgatgggtg agaaaggggt tattcagaca ggaaatgaag cggaacatgc 3243121 cgacgtgttc atgtcgatta tcttcggtta tttcattcac cgtctccact taggagaccg 3243181 ggtcatatca atgccccagg aaaaaatgct ggagcatagc acagctctat ttgtcaaagg 3243241 aatttctgct gattaactcc ttggcataat aaaaaggagg atcccaatga gctcaagaaa 3243301 agaatgggcg ctgatcgtct cgctattatt gggggccatt ctggttccca ttaactcaac 3243361 gatgatcgcg gtcgcgctct catctatttc ccatacgtat aacgagtcca tcgcaagcat 3243421 cacttgggtg gttaccgttt atttaatcgt gatggcagtc acacagccga ttgcaggaaa 3243481 gctcggtgac atgtacggca ataaaacaat gtacttatgg ggagtcggcc tttttctaat 3243541 cgcatctcta ggctgcgccc tttcaccgag tctgctcctg ttaattgtct ttcgggcatt 3243601 gcaggctgtc ggcggggcat tgcttacgcc aaacagcatt gccattatcc ggcatgttgt 3243661 ttctgaaaaa cgcctaccga aagtgtttgg atttttcgga ctgggcgcgg gacttggtgc 3243721 agcactcggg ccttttatcg gctctatact gattgacagc ttcagctggc attcgatttt 3243781 ttgggtcaac atcccgttcc tcgccattgc tttatttacg gcattaacga tgtttcctca 3243841 atataaagaa aataaatctg acgcgccgct ggatatcatc ggctctctct tgcttgcagg 3243901 cagcatcgtt tccattatcc tgctgacgaa aaatgaggct ccatggggat atactgtata 3243961 cagtgtattg atacttcttt ttgttccgct ttttttcaga agagaaaaac gtacccagca 3244021 ccccatcatt gactttgcac tgtttaaaag ctcaaccttt acaaatgcga atctatcagt 3244081 cttgttaagc aatttgatga tgtatgccgt cttattgatt atgccgttat ttatgacgaa 3244141 ccaatttggg cttaatacat ctaacagcgg gatggcgctt tctgtatttt cgatcttcat 3244201 gtcagccagc aactgggtgg gcgcgcagct ccatcacaaa tggggagcca aaaaaatcat 3244261 ttttctttca tttgccatga tggctggtgc gaatctatta tttttgctgt taagcagctc 3244321 gcattctgtc ttgttcctca tgctctctct tatccttggc gggctcgctt ccggagtcgg 3244381 tctgaccagc atgcaggttt catcccttgc cacagtagac cccggtatgt caggagtggc 3244441 atctgggatt ttctcgacct tccgttattt cggaagcatc atttcatcag ccttaattgg 3244501 cctgatttcg ggatatcaca ccctatttat gattctcttt gctgtatcca tcatcggcgt 3244561 ttttgtttca ttgggcatca aatctgatga aacggcacgg atagaaaaaa actcagcgta 3244621 acacaaaaca gcccggcatc gcatcatcct gcggtgccgg gctgcctttt atgatcccga 3244681 agcgactgct tcgtcttcac ggtcatcctt tacgaagagg atgcccaatt catgatgttc 3244741 tccttcataa gaagctcgct ggtcaaaacg aatttctcca ttcaaaccga taatttcaag 3244801 ctttacatat gcacggttat gctgaagcgc ttcatagaaa tcagaaacgt tcttaaccgg 3244861 tatgccattg actttcgtta tgatttcccc gattttcaat tccagatcct cagccggcgt 3244921 attggggata atcccaagca ccattaagcc ctgatccctt ttcgagaaat aaaacggagc 3244981 cgcgttatca ttcactcttt gctttatgga cagaaaaata cgccctaaca aagcggtaca 3245041 gaccgctgca cccgcaagcg gcgtccacag taagctcgct gcaccgagaa ctgcgacggc 3245101 aagaccgaga atacaaacgc gtttcgctgt gatccttata ctcgtttcag gcagcgatcc 3245161 ctgtaccctt tgtccaaatc cgacaaagta aggaatccat agaaaatgga atgagccgcc 3245221 gggaaccgta aacacgggcc accagctaag gtgcgattct aaaccattac cgggcacgag 3245281 aaggaacagc ggcaaaagcc aaacccggtt tgccagctgc tgtccgatcg gcaaaccgcg 3245341 gctgcttacg acaagtgccg gtgatgttct cacatgcgca gaacgataag caaccgctcc 3245401 ttcagtgata atcagcaaac ctagaaacac agccacagcc ggccaaacaa ctgcaaatcc 3245461 ttgcggaaat ctctccagaa agggctccgc ctgatatatt tgcagtccaa aacctatcag 3245521 catactcaca ctgacgatat atgcagcaga catccagttt gcgcgaagag tgaacgctgc 3245581 cgctgcagtg ataacggcaa taatcgcaag taaaccgaga ggaatcgata ttccgagtcc 3245641 acctaaaata actgacaaaa gaagacctgg aatcagtccc tttgtatatg taaatttcag 3245701 atcatcataa atatctgcta ttcttgtatg aaaggttttt cgttcccgtt tgattcttac 3245761 atagccgaaa gccaaggtta tgatgataaa aaaccagaaa agcgggtgta agaagaacaa 3245821 gcccgcgctt tttaacagtt caattcccca ttgaacagac actatctctc accgcctcaa 3245881 gccaaacatg ttactcatat tctatcaaat attaaatggc ttggatatcc tcaggagagt 3245941 ttatctctct tgcgtcatcc acagcgtgac attcgatagt gaaaaatcct ttaaatagtg 3246001 gtttacatcc acatccaata acccgctgat tagatgcatc gaccttttta tatctgtcag 3246061 attaattcct aatcgcttat ggtttttcat taagtagtta aaataatgtt tggcgcattc 3246121 ctcattaatg tcatttactg attcgacatt ggtgtaattg accaaatatc tgctgaacag 3246181 cataagaaga cttagtgctt ttgtagctga aaatgttacg tcttgtgttc tgtcttttaa 3246241 ttgttccact aattcataat attttttttt cacgcacaat acttgccctc ttcaattgtg 3246301 aacccccatt ttctttatac agataagcac gggccagtat aagcagcagt actggagtgc 3246361 taacaagcat tctcgctaac gttactcttt aaatacctgt cgttcagctg ccattaacct 3246421 gattactgtt ctttttagaa ccttcttata ttgtatgaag taaacaaaga ctaggcaact 3246481 tgcaaaagtt tcattttaaa tgcatattaa ctcgttagaa agtctctctc atatattgat 3246541 atcgggtaat aacagtcctt tataaatgtt tatttgtgaa aattttttta atttcttgtc 3246601 aaaaactcat tttttatgtg acttatgatc cataatctct ttaagcacaa agaaacagga 3246661 gatgaaatac catctccttt aattgacaaa taatgatttc aatgctgttt gaagctgcaa 3246721 atcatttttt tcatctgatt ttttcttttc tatctgctga tttaatgtct ctgcagtgcg 3246781 agtgtcgatc acaccggttt tattcagctt gttttgatcc tgaaaagcca taaccgcttt 3246841 tttcatgtct ttgctgaaat agccatcctc acgtcccgga tcaaagctga gaccttttaa 3246901 caatacctgc gcatgcttga cgtcttcatt gttcatgtcc actttaagcg gctctttcag 3246961 ctgtaagggc ccggcggaaa aataatcggg ctgcttaatc gcaatggtcg gttcaattcc 3247021 tttcttatga atccagtttc catttggcgt cagccacttg taaagcgtta atttgatgtt 3247081 gctgccgtcc cccattggca cagcctgttg aaccgttccc tttccaaaag acgtatcgcc 3247141 tacaacatca taatggccag cttcctttaa tgcgccggca agaatttctg atgcagaggc 3247201 acttccttta tccgtaatca cattgacagg gtacgctttt ttatgggtca atgttgaaaa 3247261 ataacgtttt ttatctccat tgcgttcagc aatctgaata tacggctgat cctttgtaac 3247321 gaaatgctta agaatttctt ccacactttg aagatatcca cccgggttgc cgcgtacatc 3247381 aatgacaagt ccttctattt cttttttctc aagctccctc agcgcttttg caaaatcctc 3247441 tgcggtgtgc tcagaaaaag tagagatggc aatatatccg acagaatgcc cctgtacttt 3247501 tttctctgat gcaaaaaccg tttcgagcgg aatctcagct ctcttgatcc ggaatgacaa 3247561 ctgcttcttc gttccaggcc gctgaatctt cattgaaacg ctggaccctt tttttcctct 3247621 tatttttaac acagcgtggt ttaaatcctt gccggccatc gattctccat tgatgctgat 3247681 aatttcatca ttaggcttca acccggcttt ttccgctggc gatttcttga atggagaaac 3247741 aataataatt ttgccgtctt ccattccaac ctcagccccg atgccttcaa atgaggaatc 3247801 aagagaatca gaaaattgct tagctgtctg cttgtccatg taaacagaat aaggatcatt 3247861 tagcgtagac agcattccct ggatggctcc ctcgagcagc ttttctctat ctactttttc 3247921 tacgtactca ttcgaaatta actcatacgc tttttcgatt ttgtccatag ctttatcccg 3247981 ttcagagtca gcttgtgccg tcgcgggaac tgctgcagtc tggggcttat ccatctcaag 3248041 caggttgatt cccgcatata caccggcgcc tccgaacagc atgctccctg ctgctatcac 3248101 agccattatt ttttgattca tcctttactc ctcctgtatg ccagactgtc tttaccaaaa 3248161 cctagagata gtatatgtaa aggatggaga tttcatgtaa tcatagaaga aaaagaaggc 3248221 aaatgaaaag ccgtcccgaa aacggaacgg ctttttcact ttatactcgc agaaacttgc 3248281 ggatggaagt cagacttccc catactccaa ttactgcgcc gattgcaatc agcactagcg 3248341 aaacttggaa tacaaatgga ttataaggaa gaagagagac aaatgatcct tgaacctttg 3248401 gaacgaccca tccgatgacg tattggtaag tgctcagcac cagtgcaatc ggaatcacag 3248461 aaccgaatac gcctagcagc aatccttcaa ggaaaaacgg ccagcggata aaccagtttg 3248521 tcgcgccgac aagcttcatg atttcaattt cttttcttct tgcgaaaatt gtaattttaa 3248581 tggtgttgga aattaagaac atcgccgtaa ataccaggcc gataattaac gcgattccga 3248641 tgttgcggga aacgccgacc actttaaaca aacggctgac ctcttctttt ccataagtga 3248701 ctttataaac atgatccatt ttttcgatct ttttcgccac gttcggcgta tcatgcggat 3248761 ctgtcgtttt gacgacaaac gcatcattaa gcgggttttc ctgatccttc attgtcaggg 3248821 attttccgct gtcaccaaaa ctgtcaacca gctggtcaag ctctttttct ttagatgaaa 3248881 aagtgacact ctgaatgccc ttcagttcct taatatcgtt ctgaagcttg tcctgtgcct 3248941 tctgatctgc agtcagatca atcagcactt tgatttcgac ttgtttttct gcattcgtgg 3249001 ccatgttatt caaattcagc ataatcacta aaaacacgcc gactaaaatc agcgtaacgg 3249061 ttacagcact aatggatgca aatgtcatcc atgtgtttct cccgagagat ttaaaactct 3249121 cacgcaagtg gcgcccgaga attttaatca tatgaaccat actcccctct tgactcatca 3249181 cgcacaatga taccatcttc gattgcaatg acacgtttct tcatggtgtt tacgatttct 3249241 ttattatgtg tcgccatcac gactgttgtc ccgcggttgt taatttcctc cagcgtcttc 3249301 atgacttccc aggacgtatc cggatcaagg tttcctgtcg gttcatcagc aatgacaaca 3249361 tcagggttgt tcacaattga tctggcaata gatacacgct gctgctcccc gcctgaaagc 3249421 tggtcaggaa attgtcgcgc tttatgcttc agctgcacga gatcaagcac ttcaagcacc 3249481 cgtttcttaa tgacagacgg ctgttctcca atcacttcaa gggcaaatgc cacattttca 3249541 aaaacagtaa gtttcggaag aagcttgaaa tcctgaaaga caacacctat tttgcggcgc 3249601 acgaaaggaa tctctttttc tttaattgtc gcgagatctt tatgattgat taaaatttgt 3249661 ccttttgtcg gtttttcttc tctgtaaatc attttaataa aagtagattt acctgctccg 3249721 ctcggaccaa caacatacac aaactcgccg ggatgaatgg taacagaaat cccattgagt 3249781 gcttttacgc cgttcggata ggctttatat acttccttca tctctatcat gaaatcacct 3249841 aatcttttat atcattttat ctatcacacg gtcatactct tcgaatgcat tcgacaattt 3249901 atgacccatt catttgtaaa aagatgaaaa atctgaaagt tccctttttc aatacacttc 3249961 attatacgtc aaatttagac ataatactat tacagtttct tttcattcat attgtcaagg 3250021 cataaaaaca tccttgccag cactcggcaa ggatgttttt atcttacttt ttttctgaca 3250081 gccatttggc aataacagcg gcttcgttat catctacaag cccctttggc atattgccgc 3250141 ggccgttttt aataatgctt tcaattttgt gttcatcgta tttgcctccg acctcttgga 3250201 gattaggccc tgacacacct tctaaatcct tgccgtggca gcctacgcag ctttgctgat 3250261 ataattcttc cccttcagat gcagtggctt ccgtcttgct gccagtgtct gtcttctctt 3250321 cttttgcatc gtttgatccg caggcagcca acagaacaga aagcgcaaat ccaatcatta 3250381 gtatcgataa ctttgatttc atgttgagaa gcacaactcc tttacgatct cttccatatt 3250441 ataacctcgt ttaagcgcgt ttgaaaccct cgcccagcac ctcgctcgcg tctgctacaa 3250501 ttacaaaagc tgactcatca atctgtttga cgatttgttt caatttggtg aattcagttt 3250561 gcccaaccac gcacattaaa atcggacggt catcgtcagt atatccgccg actgcagaaa 3250621 tttttgtcac gcctctgtca atcttctgta agacagcctc cttgacagcc tgctcctgct 3250681 ttgtaatgat gagcgccatt tttgaacgat taaagccgac ttgcacaaca tcaatggttt 3250741 tgctggacac atagacgcca agcatggcat ataagccttg ctcaatatta aatacaatca 3250801 tagccgtaac aacgatcatt ccgtcaatga tggcgagaca cttccccaat gacagaccgg 3250861 agtacttatg aatgatctgt gcagccaagg ctgtacctcc cgtcgaacct ttccctaagt 3250921 acacaatacc aattccgata cctatcccga caccgccaaa aatcgccgcc aggagttcat 3250981 gatgagtggc gggctgaata tcccttgtca gaaacactac tagcggcaaa aacacagaac 3251041 ctgcaagcgt ctttagtcca aatttcccgc cgagcaaaat gacgccagca ataaataaag 3251101 ggatattaat aatccactgt acatacgctg cttcaaaacc atatgattgt aaaatcgtac 3251161 tgatcccgct gaccccgccg gcggcaatct tattcggaag caaaaataca ttaaaggaca 3251221 cggccgtaat cgctgctcct atcaatatgt atacataatc ccgcaaaatc cacaatgttt 3251281 tattccgtac gtccatcata tatcctccgt ttcttccaat gctctccgat agcattttaa 3251341 tccttccctg attagatgta aataacaccc aaatacagtg gtaatatgct aaagcagcag 3251401 tgaaatcaag gatataagaa ataaaaaaac acacccgtat gcatcaggtg tgtttttcag 3251461 cttatgaaag cttagaacgc aggtaggcat caataaacgt atcaatgtca ccatccatta 3251521 cagcttgaac gttccccatt tctgtattgg tccgatggtc ttttaccatg gaatacggat 3251581 ggaatacata agaacggatt tggctgcccc agccgatttc tttttgttca ccgcgaattt 3251641 catccagctc tgcctgctgc tcttcaattc tgcgctgata cagcttggcc ttcagcattt 3251701 tcatggctct ttcacggttt ttaatttgtg agcgctccgt ttggcatgtc acaactacgt 3251761 tcgtcggcaa gtgagtaatc cgaacggctg aatccgtcgt attgacgtgc tgtccgcccg 3251821 cgccgcttgc acggtacgtg tcaactttaa tatcctccgt acgaatatca atatcaattt 3251881 catcgttaaa ttcaggcatg acttcacatg aaacgaaaga tgtgtggcgg cggcctgatg 3251941 aatcaaatgg tgagatccgc acaagacgat gaacaccttt ttctgctttg agatacccgt 3252001 aagcgttgtg tcctttgatg agcaatgtca ctgacttgat tcccgcctcg tcacctggaa 3252061 ggtaatcgag agtctctact ttaaagccgc ggcgctctcc ccatcttgta tacattctaa 3252121 gaagcataga gccccagtcc tgtgactctg taccgccagc accagggtgc agttctaaaa 3252181 tcgcgttatt tttatcatac ggctcgctga gaagaagctg aagctcaaac tcattgaact 3252241 cttttgttaa tgactttagt tctttttcaa gctcaagctg gagatcagtg tccggctctt 3252301 ctttcaaaag atcatgagtc atttgtaatt cttcgtggga ttcattcaat tttttatacg 3252361 aattgacata atcctttaaa ccgtttgctt catttataac cgtttgagct ttttgctgat 3252421 cattccagaa ttccggatca gccatttgtt catctagctc agcaatgcgg gcctcctttg 3252481 attcgaggtc aaagagaccc cctaaagtcc gctaaacgag aagccatatt ttcgagctct 3252541 gctctaattt ctgataattc catttcattc acctcattaa aagatccgca ggcgcctgca 3252601 ggcgccgcgg tcagtaaact tgccggggcg aactattcag tacggccgca gcaattttta 3252661 tattttttcc cgcttccgca gtggcatggg gcatttcgtc cgatatcaac cactttgcga 3252721 accggtgctt tctttgcttt tttgttatcg tcgccttctt gcggctgatg agctgttgtt 3252781 tgaccttgta caacctcttc acgctccaga ttgttttcaa tctcagcttt catcacaaat 3252841 tttgcgactt cgtcctcaat tgattcaatc atatgctcaa acatcgcaaa accttccatt 3252901 tgatactcac gaagcgggtt cgtctgcgcg taagcacgaa ggtgaatccc ttggcggagc 3252961 tgatccatcg catcaatatg atccatccat ttagaatcaa cggcacgaag aacgataact 3253021 ttttcgaatt cgcgcatttg ctctttgccg aattgctctt ccttctcatt atattttgtg 3253081 atgatgcgat ccataatgag ctcaagcatt tcatccggtt ctttgccgaa gatatcgctc 3253141 ttctcaagtg caccttcatc aagataagtt gtgttgataa gatcaactag accgtcaagc 3253201 ttccactcct caggaagctc ttctcttggc gtataggctg caattgcgcg ttcgagagaa 3253261 gacttgatca tattttcaac gatttcacgc aggttttcag agtcaatgac ttcaaagcgc 3253321 tgcttataaa tgacctcacg ctgctggcgg agaacatcat catattgcag aagctgttta 3253381 cgcgaatcga agttattgcc ttcgacgcgt ttttgagacg attcaaccgc gcgagatacc 3253441 attttgcttt ggattggagt agagtcgtcc atgccgaagc ggtcaagcat cgccattgtc 3253501 cgctcagctc cgaatctgcg catcaattca tcttccatag aaagataaaa ttgagtaatc 3253561 cccgggtctc cctgacgtcc ggaacgacct cgaagctgat tgtcaatccg gcgtgattca 3253621 tgtcgttctg ttccgactac agcgagcccg ccaagctctt ttacaccttc gccaagctta 3253681 atgtccgttc cgcgccccgc catgttagtc gcaatcgtaa ctgcgccttt ttggccggcc 3253741 tcttcaatga tctgcgcttc acgttcatgg tttttggcat ttaacacttg atgcggaatt 3253801 cctttgtttt taagcagctt agaaatcaat tcagatgttt caacggcaac cgtaccgact 3253861 agaacaggct gtcccgtcat gtaacgctgt gcgacatcct ccgcaactgc cttaaacttt 3253921 ccttccatcg tgcggtaaat taaatccggg cggtcatcac ggacaacagg cctgttggta 3253981 gggatcgtga caacctgcat gttgtagatg ttgcggaatt cttcttcctc tgtcttagct 3254041 gtacccgtca taccggcaag tttttcgtac attcggaagt agttttggaa cgtaatcgtc 3254101 gccaaggtca tgctttcgtt ttgaatctca agcccttcct ttgcttcaat cgcttggtga 3254161 agcccctcac tgtagcggcg gcctttcatc agacgtcccg tgaaggaatc aacaataaca 3254221 acctgtccgt cttccactac atagtcaacg tccttttgca tcgcaacgtg agcttttaag 3254281 gcctggttga tatggtggtt gagcgcgaca tgcttcacat caaagaggtt atcgatgccg 3254341 aatgcttttt ccgccttcgt cattccttct tcagtaagct gtacagcttt tgttttgata 3254401 tcgtacgtgt aatccttctc cgcttttaac gtgcggacaa aagcatttgc ctgtacgtac 3254461 agcttagtgg attttgcagc ttgtccagaa atgataagcg gtgttcttgc ttcatcaatt 3254521 aaaatagagt caacttcatc tattaccgca aaatgaagcg ggcgctgaac catctgctct 3254581 ttataaagaa ccatattgtc acgcaaatag tcgaagccaa gctcgttgtt tgtggagtaa 3254641 gtaatatcag cggcataagc ttcccgtttt tcgtcttttg acattgagtt taaattcaaa 3254701 ccgacagtca aaccgagaaa ctcgaaaatt ttccccattt gctcagcgtc acggcttgcc 3254761 aagtattcgt tgacagtcac gacgtgtacg cctttaccgg ttaacgcatt taaataaaca 3254821 ggcagggtag acgttaatgt tttcccttcc cctgttttca tttccgctat atttccgtca 3254881 tgaagcgcca cgccccccat gagctggact ttaaacggaa acatgcctgt tacgcggcgt 3254941 gaagcttctc gaacaacagc gaaagcttca acaagaagat catccgttgt cgcccctttt 3255001 tcaagacgct ctttaaattc aattgtttta tgtttcaatg cgtcgtcaga gagattttca 3255061 tagtctccgc gaatcgcatc aatatcgtta gcaatttttt cgtatctatt cagcgtacgt 3255121 tttgttggat caaacatttt atttaaaatt ccaagcattt ataacgctcc tctatcatca 3255181 cacgcctatt ttagaggcat gtataaataa tttactagtc catgtatacc tctcattatc 3255241 atatcatacc ttttgttatt tccaaagaat ttgcaaataa gaaaaacaaa aaccttccgc 3255301 ggacatcacg gaaggcttct cttcattatt cagtcggttc aattaagcca tatttcccgt 3255361 catttctgcg gtacacgaca tttgtaaggt ttgtttccgc atttgtgaaa acaaagaaat 3255421 tatggccgag catattcatt tgcaagatcg cttcttcact atccatcggc tttaaattaa 3255481 agcgtttctg acggacgatg tccaagctct cctcctcttc tatgtcatcc tgaaccgcaa 3255541 tatctgtatc agagccaaga ccgtttgcca ataaatattt tggagagccc tgctcacgga 3255601 atttacggtt tactttcgtt ttatgcttac ggatttgacg ttccagtttg tttgttgcga 3255661 gatcaattgc gttgtacata tcctcgttat gcacctcgga ccgaagcgcc agatctgtca 3255721 tcggaatcgt aacctcaacc ttagactcct tgtcattgta aaacttcaag ttgacgttca 3255781 catcagcatc cacgctatgg tcaaaatagc gctccagctt gccgatcttc ctctcgacat 3255841 gatcctttaa cgcgggtgtc acttcaatat tttctcctct gatgttatag ttcatcaaag 3255901 aacgcctccc ttttattaag gatatgtatc tatttctctt ttacccttta caattcctgc 3255961 tgaaacataa atcttttgtg aaaattcagt gaactttgtc gaattttgtt tgtatttgct 3256021 ctgttattgg cggttcggag gtatatgtat atgctgattg aacgaaacaa atacctcaca 3256081 cacgcctaat tgattaaaaa gggttccata cattgatgaa tagacagcat ccattttcta 3256141 taatgaatca gaaaatgttc ctttaaatac tcacagaact catgagaggg aaaagagaaa 3256201 gagaccaatt gatcaaactc cgcaaaaatt tggtcaaatg ctttcacaca aatttcagca 3256261 caccgcgaat ccataatgaa gagaagtgtt gaatgtgttg aatccaaata aaaaaaggct 3256321 tggatcagat cttggtagat ccgatcccct tctgtttttg ataaattctc ttcagcctct 3256381 atcaaataac acaacccctc ttcgatggta aaaagaagat gataataagc tgataaaagc 3256441 gtataatctt caatgctctt caaggcactc acctatttac gcttgtcata atatgtgccg 3256501 tcaatcgtaa tgttgttata agggtttaaa tacgtcgtat gcatcacacg ttttcttttc 3256561 atctgctgaa gttctgttgc gattgactgc ttcagtcttt ccatttcctt cacaatcagc 3256621 tgatcccatg tcaaaataag tttcatctgc tttcgctctt cttctgaaag cggcagagat 3256681 atctcctgaa tcagttcaga ccgtgtagcc acaaagtctt caatttgctt taaaagttca 3256741 tcgctttccg gcgtattttg tatgtgtgac agcatactct tcgtctcagt gtatagttga 3256801 tctatattat tcatgcgatc ccgcctgatc cgtgccggtc cttccgctca ctttgaatgg 3256861 cttgtttcca agcatcgcga aaatctgtta cataaccttc aacctcagcc agcatgcccg 3256921 tatcattttt gatatttgcc tgtaccaatc tgcgatacat ataatcgtac atcgcaccca 3256981 tagaagcgga aagctctatg ttacggttaa gtgtaaaatt taattcctga ataatatttt 3257041 gcgctttaat cagattttca tttttacgtt ccatatcatc attctcaatg gcctgagcgg 3257101 caagtcttat aaatttcaaa cagccattat acagcataag cgtcagctcc ccgggtgtag 3257161 ccgtattcac tgaattttgc tgataggctg tatatggatt ttggatcgcc atgtgtcatc 3257221 ctccaaatta catttattgt acaagaagct gtgataaata ggacgcttgt tcgttcattt 3257281 tttgaatcgc agaatccatt gcactgaatt ttgaataata gcggttttct atggtattca 3257341 atctgtcctg catatcagtt atttcagtac ttatcgagtt taaatttttt ccaatggaat 3257401 agctactagc tcccattgtc gagttcccag ctttagcttc aatacttttc acagtacttc 3257461 taagtgtatt agtaatccgc ttcataatac ctttatcgct atagttacta tcatttgttc 3257521 cacttgtaaa aagattagca actccttgag gatcttctgc tatttttgct ttcaatttct 3257581 cttcgttaat ctctaagtgc cctcgcagtt ggtaagcact tgaagttgtg atgccaaatt 3257641 cagttaattg ataggttttc ccatccgcat tcacttgagt ataaaagtca gtccgcattt 3257701 ggttcgtgcc agtgctgatg cttgaatcgt ttctcagcaa tccgcttttc gccttctcct 3257761 cccagagctc tacctcttta tcggacatgg cttctttttg ttcactcgtg agtggcgtat 3257821 agtctcggta tttttcttct ttcagctttt cattcaggct gtcaaccagt tcattgtatt 3257881 tatctacaaa ctctttgatt tggttataaa tcccatcaac atcagtagaa acagatgtgg 3257941 taacagggcc tgtggctgca gttgtatttt taatcgaata agtaacacca ttcaccgtga 3258001 aattgtttgt cagcttctcc atttcaaagc cgttgattgt gactttggca tttgtgcctt 3258061 ctttgtaagc agtaagctta ttatcagcat ccaaagaaaa accaagctga ccggacataa 3258121 agtcagctgt agcagagtct gctgcctgta tgcttcctcc tgcacctgtt gctttagaag 3258181 aaaacgcaat cgtttctacg tactctgtac cattccaaat tttatcttta aatgctgata 3258241 ctcctagatc tgagctgtta agtttagaaa tcacattatc aatcgtatcg gcactcgtca 3258301 cactaatgtt cactgttttt gctgttgttt cgccaggcgc aacaacgtta aatgccaaat 3258361 tgtaatcgcc ttgtgtgtat cccgtataat tgtttgcctt atacgttgct gcagttgcca 3258421 agctcgccac ttcaacagta gacgaagaat ttggcgcact tacgcttcct gtagcagtta 3258481 acacagactc attagagctt gtcacagttt tgctctgata cgtgctcgga tatgtcaacg 3258541 tatttttaga catataatct tgcaattctt ttatttttga gtttacttca cgatagctgt 3258601 cacgctgcca ttcaagagtc tgcttttttt gtgtcagctt atcaagcggc gctctttctg 3258661 tctgcatcag ctttgatacg atatcatcta tatccattcc tgacgccaga cctgttattc 3258721 ttgtgaccat ctcaaaccac tcctattcta ctttttttca tctacaaata acccaagaaa 3258781 ttcagtcata gccgcataaa aatcaagcca ccgttttggt ggaatttcgc ggatcacttc 3258841 atttgtagag tcctctatta cctttacata gtattcattt aacttgtcat gaagctcgaa 3258901 cttcagatga acttgcgaag gttccaaaag cttgttcatt tcccccacca tttcagcaag 3258961 attggtatat gaaacttgat gaacaggaac ctcgttatca ttatctttct gattatgtat 3259021 ttgagtatca taacgatccc aaacaggttg taacgtagtg agcctttcaa tgttcaattg 3259081 atcatcccct atgccccaat ctatcgttta tatcgactaa gtcgagataa gattacacat 3259141 atttttggaa aaaaatcttc tgttttagat ttcttgtatg gaaatacatt tataaaaagt 3259201 tagtggagaa tccggttatt atatcatgag ttagtgacag gatgaggaat gattaggaga 3259261 tagaaattta aattaaaaga ccctggcaac gccaaggtct tttttaaaat taacgtaata 3259321 attgaagtac gttttgcggc tgttggtttg cttgagcaag catagcttga gaagcctgag 3259381 aaagaatgtt gttctttgtg aattcgctca tctctttagc catgtcaacg tcacggatac 3259441 gagactcagc agctgtcaag ttttcaccag aagcgcttaa gttgttaatt gtgtgctcta 3259501 gacgattttg taccgcacca agcttagcac gttgagaaga aacttggttg atcgcttcat 3259561 caacaacttt caattgagca tcgaaaccga tatcagcagt atctgctgca ttatctgcga 3259621 attttgttac gtcaagatca ttaactgaat gaagagctgc aattgaacca tcagcttctt 3259681 taattccaag agcgtcagca cccatatcct caatatttac agagatttgc tgtgtagcat 3259741 ttgctccgat ttggaatacc aagttctttt gatttgcagg agtagctgtg tcaactttgt 3259801 aagtgccatc gagcaatttc ttaccattga attctgtacg atttgaaata ccatcgattt 3259861 catctgttaa agctgaaatt tcatcttgaa tagattgcaa atcagttgct ttgtcctgag 3259921 ttccagtgtt tccagcttga acaactagct cacgaacacg ttgaaggatc gcatgagttt 3259981 cagttaatgc accctcagct gtttggataa gagagattcc gtcttgagag tttttagaag 3260041 ccatttcaag acctctgatt tgtcctctca ttttttcaga gatcgcaaga cctgctgcgt 3260101 catctcccgc acggttgatg cgaagacctg aagaaagttt ctccatgttc ttttggctcg 3260161 cactgttgtt tgaagacaaa cggttcagtg tgttaagcgc tgcaatattg tggttaattc 3260221 tcattgtttt gttcctccct gaatatgttg ttaaggcacg tccttgtgcc cttattttgt 3260281 aactggctga gtcttttgcg cctcctcccg gctacatcat taatatcgga ttgtctctga 3260341 ttttgttaat acaaaaataa aaaaatcctc actttttttg tgaggataat gcggagatca 3260401 catcgctgga taacgctgct gcacggttat tttcttcctg aatggtcaag taaatttctt 3260461 tcctgtgaat atcaatatgc tttggggcgt caattccaag cttcacttga tccccttcaa 3260521 ccgcaatcac ttttacttca atatcagcac ctatttgaat cgcttcgttt attttccgcg 3260581 ataaaactag catgattctc ctccaatcgg atgctttgtc gtatatgagg agtcgtgtaa 3260641 aacgacttgc ttagccatca tgttcttgcg attcacaata atgggagcca ataaattcgc 3260701 agtagacttt tcaaatggct ctgccatagt caatattgtc atgacttcta cgtcttgaat 3260761 attatcgata tccaaaagtt cagcagttga ttcatcaaga tcaaattcat aattcttaaa 3260821 aaagataaac ggacttacga cgataaacgc aagattttct gaagtgacgg actgcagtgc 3260881 cacgaatgga gagtcttctg aaagcggaag tatgacgaac tgtttttctt ctaaaaagcc 3260941 tggaatcccg ctttcaaaaa gaatgatttg ttcttctttt atgttcattt ggccatggta 3261001 cttcgtatga atgatcattg ttcacgatcc ttttcttttt acttttcggg tgattctttc 3261061 gggtattcta catctatatt taaatcaggg tattgaagca tgtcaacctt aacatttcct 3261121 ggcgtatatt caacaattgg cttatgcggc tcagcctgaa taacaggctt tcgcggcgta 3261181 atctgcacat caagctgtga cggagtatat tgtattttca ccctcgaaag agaaggagca 3261241 taattttcgc ctaattgaat ttggtgcatt tcagagttcc tccttgcttg tgaagcgatt 3261301 gggttcccct tattttcaat cttcataagc tcgtcgcctt cttctgcagt gcgtgctatt 3261361 ccctccatta catcctcatg cccttgttgg gcggcttctt caattctctt gaaaacatgc 3261421 tttctgtcta attcttccca tgcttgtgtc tggtcaatcg tgagttttcc aggtgtcacc 3261481 gatatttcca tttccgcact cggctgttcg atctctagat cagcttgagg ctgctccatt 3261541 tttaagctgg caggcgtcgt tgttaaacca atttttcctt gaacactatg cataatcaat 3261601 ctgggaatct gcatcactct acctcctgaa ctataaaaaa agcgaactcc taagagccgc 3261661 ttactttaaa aagtcaatca atgtaggctg aacaatttgc gcattaacgg ccagagtagc 3261721 cctgtgcaca ctttgctgcg caataaattc agttattact tcttccagtt ctacatcttc 3261781 attgtctgat aacactttgg tagctgtttc ttcttgcgct gacagtcttg tattaaccag 3261841 ttcaagacga ttatatctcg ctccaagatc agatcgttca gcgctcatgc cgtcagaaaa 3261901 atgatcaata tcatttaaaa cactgtccat gccatctagc gaaccagaat ttagtgcttt 3261961 ctcaaaagaa tcaagcattt caaatacatt ctgcccgctt tcagaagtgc ctccaaaagc 3262021 tgactttgga tctgaattca ctttcaatga catattattt gatatattga ctacgacatc 3262081 agctgtatca gaaattgtat aagttccgtc tccgttatct gtaaccggag gcttatctga 3262141 atttgtgcca ttaaagatat atctgccgtt cacttgtgta ttcgcaatat ttaaaagctg 3262201 ttcctttaac tgctttacct ctacgccaat cgcttgccgc tccggctcgc cgtttgtatc 3262261 attttgagct tcaaccgcta attctctgac ctttgacaag atgtcaattc cttctgtaat 3262321 gtttgtttct gtgttttcga gccaggtaaa ggcttgagaa gcattgcttt tgtactgctg 3262381 cacttgagac agttgcgtat tatactttaa gcttttcatt gctactacag gatcgtcgga 3262441 agcttttgag attttttttc ctgaagaaat ctgcgactgg agtttatcca gcttcgagta 3262501 gcttgaaccg atatatctca gtgagttttg ctgtatcatg ccttgtgtta ctctcatgtg 3262561 actctaccta ccttcctcca acacccatgc cgttgatcac tttatcaagc aattcgtctt 3262621 gtaaagtcac cattcttgca gctgcattgt atgcgtgttg gaattgaatc atattcgtca 3262681 tttcttcgtc taaagaaact gcgctcattt gctgacggtt tatgtcagca tcattcagct 3262741 gtgtttctgt attagacgcc agtcgattag cctcttgagc ttcgatccct agctcgccaa 3262801 tcagacccgc ataataatct aaaacactag tttctttacc gttaatggtt attttaccgg 3262861 ttaaaacatt tgctaatttt gtagcatttg cgttatcgtt ggctgcgcca gtcagtgaga 3262921 aagcaatgtt tgcgcctttt gaatctatta tgctgtcagc cactttgatc ttgcccgccg 3262981 cgcccttggc aggttcagtt tcaccgccag taaaatcaaa aaagtctccg ccttgttcac 3263041 cgctcttggt cacaccattt ctgtgcactt cattgaaagc tttcgcgaat tcaagcgcca 3263101 tattgtcaag atcagaaagc atttccgggt atacgccctt ttcttggcca tctgctgtta 3263161 tatacccata agactctata aaccctaaaa gggatccctt gctgctaaag gactccgcct 3263221 gtacagctgt atccccgatt gaaatacttg atactaaccc agtttcatta tcatagttgg 3263281 ctgcaagttc tgaaacctcg taatttttac cgtccaaaac agttcctagc gactgtttat 3263341 ttttatcaag gatttcaatt gatacagttc cttcagcaga tgcaagtgca ttcccgcctg 3263401 atttgttgta gctgactttg atatcaacca ttgaggataa tttatcgatc agcaaatctc 3263461 gctggtcata taagccattc ggaagaagcc cgaccggctc tacttgtgca atttgcttat 3263521 ttaaactgtt taactgagaa agcagagaat tgacatccaa cacagttgta tttagctctg 3263581 cttttaaatt cgattggaca tttgtaagtg attcagaaat ataattaaac gtttcagcta 3263641 cagcttgtcc ttttcgagca acaacagaac gtgcactttc ttcatttgta ttattcgata 3263701 attcctgcag ggaattccaa aacgaattga gcacactgtt caagccgctg tcatccgttt 3263761 catttaaaac gccttccatt tgggacagcg cttttgcctt cgtgtcatag tatccggcac 3263821 tgttgttttg aagacggtat tggtagtcaa gaaagatatc tcttattctc tcaactgatt 3263881 ttccttgaac gcccgtaccc atttgtcccg ctgttttttc tgcattttta gatacagcag 3263941 ggaaatagtc agttgcctcc aatgagaccc gctgtcttgt ataaccatca gtattggcat 3264001 ttgccacgtt atttgcagta gtgcttaacg ctgcctgctg agcgcttaac gcccgccttg 3264061 cagtttcaag ccccataaag gtagatgtca ttttctgaat tcctttctgc taagcttttg 3264121 aatcaaacag tttcattttg ctacttttcg gcagctcagc tttaattgat ttgctgtaat 3264181 tgaagttatt ttccttagga accagcatat cgtacgaaat agagatgaat tgcagcgcgt 3264241 ctcttgtcag ctgcctattc atctcattta cttttttcag acgtccgaga acttgagaaa 3264301 gagattcgta tagttgttcc agctcttcct tttcactgcc tgaggttttg gcgatacatg 3264361 cggaaatagt attattttcg ctatatccga gaaaggccga agttgttttg atccggtcat 3264421 cttctgtctg cgtgattgct tgaatatatt tttgctcttt tgtcaaaatg ttagaaagct 3264481 cttttgtttt gccggctttg agcgcttccg tcttttcttc agacagcgtg agcaggtgct 3264541 catgcagaac gcaaagtcgc ttcaattgtt caataattgc cttcgctgac atgggctttc 3264601 tcctttttta ttgcttttta taaaaattaa tcatattttt cgcaatatga tttgcgtcta 3264661 ctttgtatga cccgttttca atttgcgctt taagctgcgc aattttttcc tgtcgtgaac 3264721 cagtgactgc gtcggatgca tgttgcattt ctttagcctg tgatgaaatt tcaattttat 3264781 cttgaggttg tgcaacagtt ttttgcaccg cttgcttatc ataatttttt tgatatggat 3264841 taacggattg tgttccaaat tgattgattt tcataggatt cctctcgctt tccgttgcag 3264901 tctttaaaca atcttaaccc ttttatcgac tgcgttttca gttagtttag ggaatcagct 3264961 gtttttggta ttataggcat agtatgtgtc ttttttacta ttttctttct cgattttcag 3265021 agcatcctcg tggttcaaat gatccatttg atccttaata tcagactggc aagccttgca 3265081 gaacttgcct tctctaatcg atgtcccgca cctttcacaa gggtatgcca aattaggaag 3265141 atgagtgatc tgaattcgct tctgcctgat gaatttcaat atcagctctt cttccacacc 3265201 tgtttcctca gttatccggc tcaaagttga ttgccggttt tcctgttttc ttaaaaattt 3265261 atagacagtc tcaaatgatt tttcttcttc cttaatacac gcctgacata cggtttgcag 3265321 ctttgttttt aaaaataaag cattgcattt cggacaatta gccagttctc ccatcttttt 3265381 ttctccttat tagataatat gcctgtgtca atttctagtg attatatcgg cataaaaaca 3265441 gaatcattta gcttctgatc aaggtaaaag atgacactga agcggctttt cctttttcta 3265501 ataagcagcg ggctgcgaag tgcaaggtgg cgcctgttgt ataaagatcg tctattaaaa 3265561 tgatattcat accttctgct gaattatttt ttgtatcaaa aatgcactct gacagcaggc 3265621 gttctgtttt ctttttcttt gactgtttct cattattcag gcgaatgagg ggatggtggg 3265681 aaggccggtc taaacattct gccaagagat gtgcctggtt aaatccgcgc tcttcttccc 3265741 gttccttgct cagcggaata ggtacaagaa caaaatgctt atcggggtaa accttagaaa 3265801 aggttgaaga aaaatcactt ttaaatgcat ttatgatttc tgcatctcct ctaaatttaa 3265861 aacgggagag cgtttctttc atcatatcat tatatgtgta aactgaacgg ttttgacgca 3265921 atagcaaact gtctctgatc cttgttctcc acacctcgca atccctgcat acggcatgaa 3265981 cagattgagg tctgccgcac agggggcaga tatgtcctgt gattttcttt aatttgcttc 3266041 tgcaagaata acaaaccttt tcatcaggct ttagtaaaaa aagggctctc catgtaacat 3266101 cttgagaaaa ttgcgaatca cataataaac agatcagttt atgaatgcct cctcctgctt 3266161 cgtttgacat aaatcgcttg gactctctga aactactgca gcagattcag ccaaaatgac 3266221 aagcattgct gtgttttttt gtttatctac cagctcagct ttcgtatatg cgatcttttt 3266281 aaaatcagta acgtaggatg gactcacttt gtttaaagaa agtgccaata catcgttttg 3266341 gcatacttgg caagtacagg ccatatgaag ctggtccata tatcggtcga gcagttcttt 3266401 cattacgatt tcttttgaat tgacaagcat ttttacagct cctcatcatc ggttatatga 3266461 gtatactgta ccacgttttc aaataatggc tagtctgtac attcaacttt tgctgccaat 3266521 tcattcattt cttttatatg ctttcttgca tcgagcatac tctttgtttt gccgaagtga 3266581 aagtaaatga catcgccgtc cgcatattct ttatgccggc cggttcttcc tgcaatttga 3266641 acaagtgcgc tttccgtaaa gatagacgat tccgctccta gtacacccgt ttgcaccttg 3266701 gggactgtga cgcctctttc cagtattgtt gttgtgatta atagatcgag ctgaccatct 3266761 ctgaattgct gcactttctc ctttctatgc ttgtcttccg cgtgcacaga tgcggttcgg 3266821 caatgaacac ctttaaagca cgcagcagcc ttttccagaa tagaaacgga aggaacgaat 3266881 aaaaaaacag gcctcccttc ttttacatga aactctatcc atcttttcac cgctggcgga 3266941 attttatttc ggtttaattt cttcttccag tttccacacc atacaaagcg cggttcgggt 3267001 aaaggtttcc ggtggtgtct tgcggggatg cgaactgaat gtaactgtcc gttcagtgct 3267061 tttcttttta attctttagg aggtgttgca cttaaataaa cgagggtgct gtttttcttt 3267121 cttgcttttt gaacagcgaa ttgaagggtt tgatcagcag aatatggaaa agcgtcaact 3267181 tcatcaatga tcataacatc gattgcatct ttatatcgca aaagctgatg cgtagtggaa 3267241 atcataagcg gagatagccg ccctttgtca tcgcttcctc cgtaaagcgc tgaaatgtca 3267301 gcaccctgaa aggcagcctt gagtcttgga gcaagctcta atacaacatc ggtgcgaggt 3267361 gttgcaatac atacacgcag tccttgattt aacgctgatt ctataccagg aaacagcatt 3267421 tctgttttgc cagcgccgca aaccgcccag atgaggagct cttctttttt tgatattgct 3267481 tcaattaaaa cattggcggc tttttgctgt ccgcttgaaa gcttgccatc ccatgtcagc 3267541 ttaatagact tccagtttga ttcattttcc tctttccatg aatataaagg aacctcctca 3267601 ctcactctgc ccatcatgac acaggaacgg caatacagct tattctttcc agatgagtga 3267661 taaaaagaaa aataccgctg atcagtttgt ccgcacctat tacatctata tctccgttta 3267721 tttatggata tagaattttc agcagtgata tatccattct tgatatgcca ttcaatcatc 3267781 tcatcggaaa atgagagctc agtcctgagc aaatgacggc ttcgaagcgt ctgctgcaat 3267841 tcttttgaaa aggaactgtt tttttcaact ggcacattca catagcacgc ctcctttcga 3267901 aacagtatgc ctgaatgaat attttctgtc caactattaa aataagaata taaaaaaatc 3267961 tccgctctaa aaacggagat ttggccttat ttaaaacacc agcaaattcc taacgcacct 3268021 tcacccaaat gagtgccgat taccgcgcca aaatagctgt tataaaattc aacatgagga 3268081 tattttgcag aaagctcttc aatgattttc gctgcttctt cctctcgatt agcgtggata 3268141 acagcagctc gcataggcaa ccctttactc gcatcttcgt ctaaaagctc ataaattcgc 3268201 gaaattgctt ttttacgtgt gcgaatcttc tcaaaaggca caattacctt attgtcaaaa 3268261 tgaaggatag gctttacctt tagaagacta ccaatgaagg cttgggcgct gcttaatcgc 3268321 ccgccgcgct gaagatgggc taagtcatct accataaaat aagctcgaac tgtttttttc 3268381 atttcttcca gttcttttat aatatcttcc ggcgatgatg ctccgttttt gattaattca 3268441 gcagctttaa gggcataaaa gccttgagcc aagcagctga tctctgagtc aaatggatac 3268501 acatcaatat tgtcgaccat cgaatcagcc gctgctgcac tgctgaatgt tccgctgatc 3268561 ccgctggaaa gatggatact gataaccgca tcataagact tgccaagctc ttcatacaac 3268621 gcaaccagct cgccgattgg cggctgagaa gtcgtcggga gctcattatg ttttttcact 3268681 tcttcataaa agcttttcca gtccaactca atttcttcac ggtaagtctc ctccctaaaa 3268741 acaacctgga gagggatcat atgtatctga tgttgttcac gcatttcttt cggaatatat 3268801 gccgtgctgt ctgttacgac tgcaatattc atagcttcga tacctgcctt attgctttat 3268861 aactctattg taagggaaac ggcagcctaa aaaaagacct gcctagtaaa aggcaagtct 3268921 cctattatac tatctcattt ctacccagcc atttttaatg gcgaccacaa cggcttgcgt 3268981 ccggtcgttt acattcattt tttgtaaaat attgctgaca tggtttttaa cggttttctc 3269041 actgataaac aatgattcac caataccgcg gttgcttttt ccgtctgcaa gcatctgcag 3269101 cacttcacat tcccgcctag ttaaaatatg taatggtctg cggatttcag ggtaaacctc 3269161 atgttgaggg tgtgcagaaa ctccgcttgt tgcaaggcgg cggaattcgt taacgaggtt 3269221 gtgagtaacc ttcggatgga ggtaagatcc gccctcagcc actactttaa ccgcttcaat 3269281 taatgtatca gcatccatct ctttcagcag ataacctctt gcacctgttt tcagggcatg 3269341 tgttacataa ttttcgtcat cgtgaattga tagaataatt actttagatt caggatacag 3269401 ctctacaagc tgttttgtag cttccacacc atttacgttt ggcatattga tatccatgat 3269461 cacaacatca ggatgatagt gctcaacaat acgagccgct tcgtccccgt catcaccttc 3269521 ggctaccact tcaaaggtag gttcaaaatc caatatccgt ttaacacctt cacgaaataa 3269581 ctgatggtcg tcgataataa caatgtttac tttagtcaca agccacgcct ccttgtatta 3269641 ttgttctata tactctagca ttcggtcaat atgccttttg gctctatttt acaaatcata 3269701 gtcaaagaga taacggaacc ttaatcataa taaatgtccc aagacctatt ttcgaatcta 3269761 ttgtcatcgt tccttccaat aaatctactc tttctttcat gcccagcaag ccgaatgatt 3269821 tgtttttctt ctctttcgct tccttcaggt cgaacccttt accgttatct tttatcatta 3269881 aaatcacaaa atcctttgtg atctcaactt tgactgtaat ttcttcagat tcagaatgct 3269941 ttagcgcatt agacacagct tcctgtgcga gcctgaagag cgcaacctca aactgaggcg 3270001 ctagcctctg atcctctgtt tctccaatgc actgaaaatg tattttgacc ttcccgttat 3270061 attcctcggt tgtatataga tattttctta aagttggaat caggcctagg tcatcaaggg 3270121 ccatcggtct taaatcatat ataatccttc tcacttcgta aagggcattc cgaacatttt 3270181 ggcggagatt tttaatttct tggaatccgt cctctgcgcc ccggtcacgg aaaatccgct 3270241 cgattaattc cgatctcatc ataacattcg ccagcatttg agcgggtccg tcatggattt 3270301 ctcttgagac tctttttcgc tcttcttcct gcgcctcaat aattcttaag ccgaaatcct 3270361 gttttgcctg agcatcagca agaagcagtc caacttcgcg caaatcctga ttcaagtagt 3270421 tgagcacaac tgtaatttgg cttactaatg attctgaccg ctcaatgatt tcctgaagcc 3270481 ctagcaatct gcgctccaaa tcgtcccgcc gttcgcgcaa ttgcttctca cgctgctgga 3270541 tcatcgtcaa ttctacctgc agcttatggg ctttttcata agcattgcgg atttcctctt 3270601 cactgaatct atgaaaatta cggctgacct cggataaacg gtttctcgca tggcgagttt 3270661 gcacttcaag tttatcgcca agctcaatca cttcatacac ctgctgttta atttgtttca 3270721 gttcttcgac cagctgttca tactgctggc gtgactgctc cccgatttga aaaacctcgt 3270781 ccttgctccc gtcaacggtt ttcagcatct tcatcaaaat agaatccagc actttggaat 3270841 ccatctttgt tttattcata atttccctcc gtcacggcgt tgtcatatat ttttattata 3270901 aatgtaattg atctgcaaat tatgtcgaat tataatgaaa gaatgcgtat attctagaaa 3270961 aaaacatttt tatatactat ctactcttta tgataccaaa atacgcacaa aaattctaaa 3271021 gactgtacga atttgtatag gcagtctttt atgcttagca ggagggtcag ctagcatgct 3271081 gcacagctat tttactgtga aagaagcggg agaacacgag attgttatag aaaaatcgcg 3271141 ttttatctgt catttaagcc gtgtttctac cgaacaagag gcacaggaat ttatacagaa 3271201 aataaagaaa cagcactgga atgcgactca taattgctcg gcttatgtta ttggcgagaa 3271261 tgatcatatc caaaaagcca atgatgacgg ggaaccaagc ggtacagcgg gagtgccgat 3271321 gctcgaggtt ttaaaaaaac gcaggctgaa ggatacttgc gccgtcgtta cacgctactt 3271381 cggaggcatt aagcttggtg ctggcggatt aattcgcgct tatgggaaat cagtgtctga 3271441 aggattaaat catataggtg ttgtagaacg gaagcttatg cgaatcatgc atacttctgc 3271501 agattacaca tggcttggca agattgaaaa tgaattaagg gagtcacaat ttctgttaaa 3271561 ggaaatccat tattcagaaa atgttgaatt cgaaacatac gtggaagaaa aagaaaccaa 3271621 cgctttttct gaatggatga cagaactgac aaatggaaag agtgatatta aagagggaga 3271681 gttgacgtat cttgaaaaag ccgtcaatca cataaaggag actgaataat ggctgaacgc 3271741 gttagagtgc gtgtgcgaaa aaagaaaaag agcaaacgta ggaaaatttt aaaaagaata 3271801 atgttattgt tcgcccttgc actattggta gttgtagggc ttggcgggta taaactttat 3271861 aaaaccatta acgctgcgga tgaatcgtac gatgccctat cccgcgggaa taaatcaaat 3271921 cttcgcaacg aagttgtaga catgaagaaa aaaccatttt ctattttatt tatgggaata 3271981 gaggattacg cgactaaagg acaaaaaggg agatcagact ctcttattgt tgttaccctg 3272041 gatcccaaaa ataaaaccat gaaaatgctg agcattccgc gtgacacacg tgtgcaatta 3272101 gctggtgaca caacgggaag caagacgaag atcaatgccg cttacagcaa aggcggtaaa 3272161 gatgaaacag ttgaaactgt tgaaaacttc ttgcaaatcc cgatcgataa atatgtcaca 3272221 gttgattttg acggatttaa agatgtgatt aatgaagtcg gcggtattga tgttgacgtg 3272281 cctttcgatt tcgatgaaaa aagtgatgta gacgaaagca aacggattta cttcaaaaaa 3272341 ggcgagatgc atttgaacgg cgaagaagcc ttagcatatg cccggatgag aaaacaggat 3272401 aaacgcggag actttggccg taatgacaga caaaaacaaa tcttaaacgc gctgattgac 3272461 cgcatgtcaa gtgcaagcaa cattgctaaa attgataaaa tcgcagaaaa agccagcgaa 3272521 aacgttgaaa ccaatattcg cattactgaa ggtttagcgc ttcagcagat ttacagcggc 3272581 tttaccagca aaaaaatcga cacattgagc attacaggtt ctgatttgta tttagggcct 3272641 aacaacacat attactttga acctgatgct acaaatctcg agaaagtcag aaaaacgctt 3272701 caagagcatt tagattatac tcctgataca agcactggca cttccggtac cgaagacggg 3272761 actgacagct caagcagttc tggcagcact ggcagcactg gcacaacaac tgacgggacg 3272821 acgaacggaa gcagctattc gaatgacagc agcacaagct caaacaacag tacaacgaat 3272881 tcaacaactg attcatccta ttaaaaaatg cccggtcctt ttagaggatc gggcattttt 3272941 gcgcagaaaa aaactccggc acataagccg gagtttttaa ttccttttca ccagccgttt 3273001 ataaaacttt gtaaacggct taaatttttc attcacgagt cctgtcactt ctgctatgat 3273061 ttgcataaaa ataatcaaaa tgaagataat aaacaaagaa agccaaattg tggcactttt 3273121 aagtacaatc gcactgatac tgaaaataaa tccaattaaa taaataacta agaccgacat 3273181 ccgatgtgaa aggccaaagg ccatcagtct atggtgaata tgcgacttat caggcgctga 3273241 aatcggctgt ttgtttaata ttcttctgat gatagcaaat gttgtatcaa aaatcggtac 3273301 gcctaatata ataatcggga taacgatact gaacaatgtg acacttttat acaggcctaa 3273361 taatgaaaga atcgagatac tataccctaa aaacagtgat cccgtatctc ccataaagat 3273421 ttttgccgga tggaagttgt aaaacaaaaa ccccagcgtg ctggcaataa cgactaatga 3273481 gagtgacaga atgagcactt ttccgccgga tagcgccatg acagcaatcg ttgacaggcc 3273541 gataacagaa agaccggcag caaggccatc caatccatca atcaggttaa ttgcgttcgt 3273601 gatgccgaca atccataata ccgtcagcgg ataagccatc catcctaact caaatcgttc 3273661 tgttaaaaaa ggtactgaga aaaagtccat ttttaagcca gtgcttacaa tcataatggc 3273721 tacacctaat tgaatcaaaa acttaacttt tgcacttaat tgatatttat cgtcaagaat 3273781 acctaacaca ataatgatga atgctccgac tgtaattgcc gtcatccttg tttctgtgta 3273841 aataccggat gcaagcacgc ctgcaaccac cccgataaat atggccagcc cgcccatgcg 3273901 gggcatgatt ttgtcatgta cttttcgatt gctgggctgg tcaactgcac ctattttaat 3273961 cgcaatcctt tttacgattg gggttatgat taaaactgtc agcagcgaga caataaacgc 3274021 aacaacaatg cgaatcatgc gttcgtcaag cataaagaag tctcctttgg aattaaatga 3274081 agtctttatt tatatagaga accgttcctt ccattatacc ttctccttag ttattataac 3274141 aagcttcatc aaaaagaaac acgtataatc aaaaaacgcg catcccaatt tataggacta 3274201 cgcatgtttt tgaatccctg tatatttcat aatttgtcta aataagcaat tccaatcttg 3274261 tgtccgggcg atgtttcggc gcatttcttt ataggtctcg tctccgtttt gaccgagaac 3274321 tttttcacaa gcggctataa aatcaatcgg atgatcgccc tctacatatt cgtatacata 3274381 cggcttttgc atttttgagg ttgacggaag attagtgcct acaacaggtt ttcctgccgc 3274441 taaaaattca aatagtttca gcggaaacac agcttgatta tacggtgatt gtttatatgg 3274501 cataatgcca atgtcgataa gctccatata atgaggcact tcttttggat ctgccggacc 3274561 ggtccatatg acattgggaa gcctcagcag ctcttgaaac gaaacatcac cattggtggc 3274621 atccgggcca acccataaaa atgtccaatc aggcttttgc agtgccgctt ctttaatcat 3274681 tttaaaatcg agcttcggtt taatcccgcc aataaaacct aacactattc cttctctccc 3274741 ctgcagtata ctgcgatcgg gagcttgttt atttgcagaa aacagctcat actccacacc 3274801 gttttccaca gtatgaacct tttctcgtcc tgcagtcagt tttttgtcta cttccttgtg 3274861 aagataatct gatgaacagg ttattgaatc tgctcgttgt ataattctca gctctgccga 3274921 tttaatgact tttcgccgga attcagacag cagatttgat cggccgctga tcggcgcagc 3274981 ccataggtca ctgcagtcat aaatgacctg atcccaagaa tacagcgaag acagcagcgg 3275041 gaatccggga aacgtgtacc ataaacagca gcgttcaccg tttgcagaag caggtgtaag 3275101 ctcatcgagt aatggggaga gcttatgtct gtaaaagaca tctgtatatc gtccgaaacg 3275161 aaacattttt ttctgcagca ggtctttgac agcgaattgc ctgatgccag aatggacttc 3275221 ctgaaactct ttcccttggg cacgcggagc cggacatacc caaataactt ccttcgtttc 3275281 ctcctgagca gctaaaaatt ctgccagccg gtgccttctg tatctcaatt ggtcttttcc 3275341 ccattcagca gtggcaacga tgacatgaat gattgcttct tttgtttcca ccttcatcac 3275401 cttttctctc tgtttgcagc tataatcttt ttttcaccgc gttttttgca tattgaacaa 3275461 aacaccatgt tgctttcata aaatgaagcc gttcgatctc cctgtagaca aaccacgttt 3275521 ttttcgcagc cttccatttg ttgctggaaa ttgaattatt gacaagccga tattcagcca 3275581 ggcattcatt cattccatag gcagtaaatc ctttttttaa aagagacagc catgtggcta 3275641 agtcctgtct cgttctgata ttcggcattt ggatctgtcc cgtttgctcc ctgtcaatca 3275701 tcaccgtcaa gcagccgata attgtatttt tcagggcgtc atcgtacgtc aggctttccg 3275761 gcgcatgaat aaatttatcg agcggggtcc cgtcctgcgc cattaagctg tagcccgtga 3275821 aagagaacgc acaggagcgc tccatcataa actcaagctg cttttccagt ttgtcttttt 3275881 tccatttgtc atcactgtcc aaaaatgcta cgtagcgccc ttgagcgcgt tccaacgctt 3275941 tgttgcgagc aaccgcagct ccggagttct cttccagata caccacatga attctttcgt 3276001 ctattttttc atactgctgt aaaatgtcgc gggtcccatc cgttgagcaa tcatccacga 3276061 taatcatttc ccaatgagga tggctctgat ctaataccga atgaaccgtg tcttcaatat 3276121 agtcacgcgc attataggaa ggtgtaatga cagatacgag aggtttccaa ttggtcatga 3276181 tcacatctcc atcgtatgat tttaaaagga ttctctgaaa aattcaggaa tgacaacgaa 3276241 cataaaggca atcgtaaggc caatcataac gccgagaact gctttctttt tcggagacat 3276301 accgccgcct gctgtctcac ttacggtttc ggaatcagta acacttgccg ctttcaggtt 3276361 aagctgtgtg tttttgagtt catataaaaa tctctcttta tccactttgg aatcctcgct 3276421 caccgactcg ccttcaagcg cgtctatgct gctgcggatg acggcttctc tttctgcata 3276481 cagcttttga tcgtttttga ggaaggtgga ggatatggcg tttaagacag attccgttct 3276541 atccttatcc tcgtcactat agcttaaagt cagtaacgat ttggattccg tattgattgt 3276601 aagcttctct ttgatctctg ctacatcttc atccttttca tcaggaagcg cctccttcaa 3276661 aaaggagtcg ctctttaata gaagcggaat ctcttctgtg ctgttataaa ccggatgatc 3276721 atagctcccc acagccaaag tatcttcagc tgtatagctc ttttgatcag cgatctgtga 3276781 cggcaggata taccccgccg cacctaatat aattggcacc gctatgatcc aaatgatatt 3276841 tttttttatg cgacgggcta ttcttatcaa tatatcgttc atataagtct ccctgctttt 3276901 tgtagtctgt ttatctgtac atcggctcag gcatttgtct ggatcgcctt aacacattca 3276961 cggcggcgat gacgagcgcc ataaacaccc aatggaaaaa taaatttgaa acagagcttg 3277021 ggctgatact tgataccagg aaactgacca tagcggtaat aagtccttct gtgatcagtt 3277081 ttgactgatt ttctaatttt ctttcataaa acttgtaaag cacccatatg aggtaggcat 3277141 aaacggacaa atatcccagc atgatgaaca aaccaaaatt agcaagaatt tcaacaagcc 3277201 agttatgcac ctctgccaca ttgtcagtat catatacagc ataatgctca agataatagg 3277261 atacatttcc tgccccgact ccgaatccgt atgaatcaag gaaaaaatgc caagcgtttt 3277321 tcagcagatt tgcccgagcc acatttgatg gaagcctgtc atgaaatgaa tgcagcgtct 3277381 gcggggccag aaacagctcc caaaactttg aatagatttt gctggcgaaa agaactgcga 3277441 aaagagcaat tcccgccgcc gacagccata tagccattct ctttaaaaca ggcggcaata 3277501 caatgaagat gtagacagca atacctgcaa aaatgcccag aaggctggct cttgaaccag 3277561 tggcaaaaat taaatacaac gcacagagcg agagcacaag gccaattgcc ttgatgtatc 3277621 cattcttaat gtttttcatc atcgtgatgt aaaaaaagaa gctgatggat aaaaaggtcg 3277681 caaagtcatt ttgattaaaa aagaccgatg tcggataatg ctgcttgtac tccggtccgc 3277741 tgtacaatgt ggaactcgca agatgatggt gggtgatatg attgtaaaaa ccaatgatca 3277801 tcagaaatac cgtcatcacc agccaaatgg cataaacaat catcagccgc tccatttttt 3277861 gcacgtacat gacaataaga taaatgaaga agatccccat tgccaataag gctaaatact 3277921 tgaggccaac tgttaccgac ttggcccaca gcagagaaac aaggccatat ataaaccaaa 3277981 aggcgaaaaa gagtaaaatc ccttttactt gcagcccatg ccatctttca atatgggttc 3278041 gattccgaac catgccgaaa atatgaaggc aacccgctgc aatgagcaga agccggtaaa 3278101 ggaacaaact gaaaaatcca agatgaatgg caaaaaatgc attatttaaa aaagtgcagg 3278161 cgatcaaaat atagattaca gccataaaga gccgttcttt tgttgtaaat gcggttgcaa 3278221 gcgtcagtaa aaacaggcca attgccaaca ccgcaagcac agcagccatc tgcatgaaac 3278281 ctatatcttt atggatggct cccagcaata ggacgactcc aaatatagca gcggccagta 3278341 acgctagcgt atggaccgct gatcgtttga tactcacatg tttaacccct ttcctgatgt 3278401 ttcaggagcc ggcggccgag cctagcagcc ggcagcttca accaagtaac actttttctt 3278461 tttataaatt gacgcttccc aagtctttag ccaattcttc aagcggcaag cccggaaaat 3278521 acttgtcaga gggttccgtt ccccgaacag cgggacggcc gatagagtga taaatgtatc 3278581 cggctgcctg catctcttca agtgaaaata aatttctgcc gtcaatgatg actggctgtt 3278641 ttaagagggt tttcactttt acaagctcca tttctttcac ttccggccaa tccgttaaaa 3278701 tcaggcatgc atcagtgtct tccatcgcag catacacatc tgtgtaatac tcgacctgtt 3278761 cgccaaggat cgctgaagct tcaggaatag caatcggatc gtatgctttt acatgggcgc 3278821 ccagctgctg cagcattggg ataatatcaa gcgctggagc ggatctcaca tcgttcgtat 3278881 tcggtttgaa ggctaatccc aggactgaaa tggttctccc tttgacgctt cccataacag 3278941 tcaaaagttt atctacaata tgaacacgct gcttttcgtt cgtttcaatg acagcttcga 3279001 tgagcttgaa tggatagcct gccgattttg cgatttgaag cagcgcggtt gtatcctttg 3279061 gaaaacatga accgccgaat ccaataccag ctttaaggaa ctttctgccg atacggctgt 3279121 caagaccaac accatcagca acttttgaaa cgtctgcgcc gactcgctca caaatgtttg 3279181 cgatatcgtt gataaaggaa atctttgtcg ccagaaatgc attcgcggcg tatttaatca 3279241 tttctgcact ttctaggttt gttttaatga caggagcatg gaatggctga tgaagttcct 3279301 caatgatggc agcggcttta tgacttgttg aaccaatcac ggcacgctcc atattcatcg 3279361 tgtcatgaat cgctgaccct tcccgaagga attcagggtt agatacaaca tcaaatgagt 3279421 atctcccctt tgaggctttt tgaacgatag attgcaccag tttccctgtt ccaaccggga 3279481 ctgtgctttt atttacgatc actttgtagc cgttaagatg ctcaccgatt gttttcgccg 3279541 ccgctttgac gtacgttaaa tcagcttcac ctgttttgga cataggcgtt ccgactgcaa 3279601 tataaataat atctgaggcc cgaatggcag acgggatatc gttcgtaaag gtcaggcgct 3279661 gatccagcac atttttttca actaagtctg caagccctgg ttcatagatt gggattaccc 3279721 catttttcag gcttctgatt tttgattcat cgatatcaca gcaaacaact ttattgccga 3279781 tctccgcaaa gcaagtgcct gatacgagtc ctacataacc tgttccaatg acagctattt 3279841 ttttcacagc gctcaaccct ctcctgtaaa atgatcttcc aatttataat ggtcgcagtg 3279901 tcttacgatt aaacggacgt tttcgtgacc gtctgatact gatgatgcaa ggccttggcg 3279961 ttttttcctg cgtcaaattg agcctgcacg gtttcataca agtcatctgc tacttccggc 3280021 ttccatattt gctcatgttc gtaccgagtg atcgcttccg ccaaggcttg agcggatttc 3280081 ggtttaatca gcagatgttg gtgctttccg aataaagacg acactccgcc aacatccgta 3280141 caaataacag gaacccttag cgccagcgcc tcaatcacaa cagtcggcat cccctcactg 3280201 taagaaggaa gtacgaatag atctgccgca agtaaatagt ctcttacctg atgattcggg 3280261 acttggcctg tgacgatatg ccccttctgc gtcagcgtcg attttgcggg accatccccg 3280321 acaaagactg ccttaggaga gtcctgcagc gattcgatcg cttcagacag ttcaaaaatg 3280381 cctttctctc tgaccagccg gccgacatag acagccagac gctgatcgag cgggagtccg 3280441 agtctttttc tgatttcctc tttcgtctcc tcattcccct gaaaacggct gagctgtatg 3280501 ccgattggca aaaccgagct gtcaaagccc gaaagctttt tggcttcttc ctgaagcttg 3280561 tggctgactg ctaaaacaac tgacgcagaa cctacggcac gcttgaaggc tttaaacgca 3280621 cctttgctgt aatgcggata gacattcaca tcactgccat gcaaggtcag gacataagga 3280681 atttgcgctg actctgacac gactgccgca gccccgcccg atggcatggc aaaatgcgca 3280741 tggatcagat ccggatatag gtcgcgctgt ttcattgttt ttaaaacggc tgatgcgatt 3280801 ctccgatgag gctgcgccca cttcagctgg ccgggaactg cccgatagaa aggccggtaa 3280861 accggtatcc cctttctaat ctcatactcc ggtctgacat ccttttttcg atatgtcttt 3280921 ttcagcatgc ggacaggtgc tgaatgaaaa ggccgtgggc atatcacagt gatatcaagc 3280981 ccgagttttt gcagctcttg cacctgtgtc tcatgaaaca caccctctcc gggtttcata 3281041 ctgctcggat atacgcttgt gatccacaaa atcttcatga caaacgtcct tttcttagta 3281101 gtttgctttt cgtttgaggg tacgctttta ccaaaagaaa gagatagcac agcgccccag 3281161 ccgcaactga aatggccagc cgcatttctg cctgcatact gaagtgttcg gtactgaggc 3281221 ttacaccaaa cgcgatgatg cccatcgccg cagtaatcag aaatggcttc ataatcgact 3281281 ggaaataagc tgaaaggtta agcttgatga catatgccaa aagccagcgc ccaatcagga 3281341 aattaacaac gctgataatg gcatacaccc atgcgactgt cagcaggctt cccgtctgta 3281401 cagctgcaaa cagtgataat ccgtacagca gcagcacgcc ggaatcccaa taaaacgcta 3281461 agtcagctct tcctttagcc agcaacacag atccatttgg attcatgagc actcttagta 3281521 ttccgacaat cgcaagaaca tttaggatcg gaacagcagc aagccatttt tctccgaaaa 3281581 ccgctgtgat aaaggcgtct gacacagaca cgagcccgat taacagcgga aacgaaacaa 3281641 gcgccagcat ttttgtcata ttcagaaagc cttctctgat cacgctgttt tcatatttgt 3281701 tttttgcgaa aatagggaat gccacccgtg tgacaatcgg attgatcttc aaaaccggaa 3281761 tggtgacaat ctgataagcg aggttataaa tccccaatgc ttcagcacca ataaaccggc 3281821 cgatcaaaat catgtcgata tttgctccca gcctgttcac aagacgggat gaaagctgaa 3281881 aggctccaaa agaaaagaaa tccttcatgc ctctcaaatc aaaaacaaaa gcaggatgcc 3281941 acttttttcg gtatacagcc caatataaaa tccctttact ggactgcagc aggacttgag 3282001 aaatcacgta cgccaaaatc gcatccatca taaaaaccgc tatcgctaaa tatccgaatg 3282061 acaatacatt tgaaaaaatc tctattttgc ttaacgtatt aaaatgcagc tgcttttgca 3282121 gcatatactg atattgctgt ccaattggcg cgatcaaaaa cataatcgcc agaatccgaa 3282181 ccagaaacac cagctcttct ctttgataaa atcccgcaat gacaggactg ctcacatata 3282241 aaagaacaaa cagcaaaacg cccgtcataa tgttaagcca atacaatgtt gacagctggc 3282301 gctccgtcgc gtcgtctctc tgaattaatg ctgcgccaaa acccatatcg agcacaatct 3282361 gggcgaaaac tgtaaccgtt gtgatcatgc cgacaagccc aaattctgtt aaggtcatca 3282421 tatttccaag cagggcaaac tgaacaattt gtatgattgt aatacacatg gttgaaatac 3282481 ttgtccactt tgcaccgctc atgatttgtt ttgtaatact tggcatcata ttccctactt 3282541 ctttttaagc tcagattgat ggtgaataat ggaatcccgt tttatcttgc accatcaccc 3282601 gtccaaacta ctttacaagt ttttaacata atttttaatt ctaaagtgaa agtcagattg 3282661 cgaatgtaat ataaatcaaa tatcagcttt tccttcggcg tcatatcgta accgccgttc 3282721 acctgagccc agacgctgtg taaagcctgg aatctcattc tggaattttt ccgtaaatac 3282781 gggccgttcc ggacgagggc caatcatact catatcgcct ttcagcacat taaacagctg 3282841 aggaagctcg tcaattctcg ttcttctgat aaaagctccg atccttgtca cccgcggatc 3282901 ttgcttctgt gcccaaaccg ccccagactt ctcggcatct attttcatgg aacgaagctt 3282961 ataaagctta aatggcttcc cgcctttccc tacgcgttcc tgcgtataaa tggcaggccc 3283021 cggcgtctcc aaacaaatca aaattgaaaa taccgcaatc attggcagcg caatcgccaa 3283081 tccaatgagc gcaaaccaaa tatccattac gcgctttatt gccaaataac gagccgtctt 3283141 ttcagataat gtaaaagaat gtatttgttg aactgagaat tcacgactca cattcatgct 3283201 tttctctgca ctcactgaca cacacctcac gatttgtttg ggatgttatg atgacctatg 3283261 ccagtcagtt tagcagacgg atgttaattg gatgtaaatg gtatgttaag aagtgtgaat 3283321 tacgtgtttt ttctgataaa tgttgttaat actcttttac tattttatat acaagtccta 3283381 tttgttttaa tcatttcata taaaaaagag acaaatctgt gattagattt gtctctttcg 3283441 attatctgta ataagatact gtgccgtcat gaatagcttg tgcagcttta tctttataaa 3283501 ccgcttgctt caatttactt gcatctgatg cattagtgat aaaggcagtt tcaactaaaa 3283561 cactcggcat tttagaatat ttaataacat agaaagcagc tgtttttact ccccggtctc 3283621 tcgttccaag attagccgct aactttggtt gaatttgttc agccagtctc ttgctatttg 3283681 cagcttgata tgttgtatcg tagtacgtct cacttccatt tggtgatgag ctatcattag 3283741 catttgcatg tatactgaga aataaatctg cttgtgcaga agctgcttta tttactctct 3283801 cctgtaaaga ataaaaagta tcattagatc ttgacagtac tggaagagca cctgaagcat 3283861 ttagctttgt attgactctt ttcgctatat caaggttgac ttctttctca aggagtccat 3283921 tgccgattgc tcctgaatct tgatcaccgt gacccggatc aataaagatt gtttcaccta 3283981 caactggatt ctttagctga ttagcaacct ttgtgcttac ggcaggagtg tttccgataa 3284041 tcataaagtt tgacatgttt ttacttccaa taattttacg ggctcctgta gataaatttt 3284101 caccatttgt aagaataaga gattgcttct tcttagctgc cagtgtagct cctgcaatag 3284161 agtcagggta gctgaatcca ttgcttacat atacggtgct tgttgataaa ttaagttttt 3284221 gtacgatatt tgcagcaagc tcatatctgt ttgaaccgct aattcttgta ggagaaggta 3284281 acttgttgta taccgtattg ctgatacttc cagtgcctcc tacaacaacg gtactcgaaa 3284341 ttcccttatc ttttatcaca gacgtagtcg cactatttat agatgtttta tttgtaaaaa 3284401 gaattggata cccgtttttc gctgcataag ggatgacggc cggagcgtct gcatataaga 3284461 agccgttcaa aataacagct tttgaagtcg cacccatcgc ttttgccacc cgtgcagccg 3284521 tatcataacg gttgcttcct gcaattcgtt taatacttat ccccaagctt ttaatctggt 3284581 tagcagtgtt agaagaaaca gcaggtgttc cgcctacaat aattacattt ttagtctgca 3284641 tctctttcaa tcttgttttc gtttcatatg aaagcttatc agaattagtg taaagcaatg 3284701 gcgcattctt ctggtaagca agaggtgctg ctgaaatagc atctgcatag gaactcccac 3284761 caacaattac agctgtactt gctgttgaat acatttgctt tgatatttgt acagcagtgc 3284821 cgtatctatt gcttccccca actcttttca ctgagttatc ggccaaagct gttggcacaa 3284881 aaagtatgag ccccagaaaa cacattgtta ggacttttat ataagaacgc aattgatttc 3284941 ctccttaaat ggcgttatat cctaaaataa tcaataactt gtcagagttg tacctggata 3285001 gtaaaatttc aaaattgaac tatatgaatc tccagcttct gctcttgctt ttgctccata 3285061 ttgactcatt ccgatcccgt gaccatatcc tttaccgctg attgtgtact ttgaagtatc 3285121 tttttttaca gtcacataag tacttttaaa tacagtcgct ccaatcattg ttcttaactc 3285181 acttgttggt acactaatgg ttgtaatttt gctcaagtta taggagccag tactgctttt 3285241 aacaaaatac ttcactttca tcgatgctgt ttttgcacgc tgcccttgtg tcgttccact 3285301 aaagcttaaa tcgtcaatac ttgcaatttt gacagaatca gcgcttgttt ctttattttt 3285361 caagatccag ttcttaactc cggaaagtct tgcagaatca gtttcagtcg ctgaagacca 3285421 ccaagaagaa ggcttcgtta agtccaaaga tttcgtatct agctgttgtt ttgacaaagt 3285481 aagcgtccag cctatttgag gatcctttgt atcttttttt gcaatcaagt aaggtacact 3285541 tgacgaccac acttcattac tagcttctgt gtaaccacca ttactggaag aataagctgc 3285601 agttataaga gatccattat atttcagaac tttccccttc gtttgctcta ccgctttatt 3285661 ggtattcgaa ttccaactgt agccaccata aacttgaaaa gcggttgtat caggtacagt 3285721 agttcctgtt tttgttattg agtaggttct tgcagcgaca gtctgtgctt taagagcctc 3285781 aagtgaccag ctagcaggca tttcattcgg aattactcct tttaagtaat cctcaaatgg 3285841 aatattctca tttaccggtc ggatatattt agtagactca atagagaaat taaccgtgcc 3285901 aagatactgc tttccatcaa gactaattct gtttgaagta gaatagtttt ctggtttaat 3285961 tcttagggag tttccgtaag ttttgatgtt ttcaaggttt aattttccgc tgttgatttt 3286021 tagattatag gtgccaccgt cagctaaata aaattcatca gcaagtgaat tctcaacttc 3286081 agcagaaatt gaactggtac ttccaataaa gtcgtatgca tatgtggctt tatctttcgt 3286141 tatactttta gccgcagccg gaacgctatc ttgtttaaca aataaaattt ggctgttttt 3286201 cttcgaggca agcgaagcgc ctatcaatac gtctgcatat tttgtcccgt tcgtcattac 3286261 gactttatca gccttcaact ttagttgctt aattatattt gccgtaagtt catatctggt 3286321 tgatccagga atcctttgca cagttgaagt ttttttaatt tggttttcta cactatcact 3286381 gacgctaaat gaactgccta taatgatgac ttgttttggc aaatcataat ccggaagctt 3286441 gtctttctct gtaagcaaaa tagggtatcc gtgtgctgct gcatatggag caatggctaa 3286501 agcgtcttga aatactcttc cggttacaac gatcgcttta tcatagctgc ccatttgctt 3286561 tgcaatattt tctgataaga catatctatt ttttccgctt atccttttca cagcgccata 3286621 tgatttcagc ttgttttcta cgtcttttga aatgcttcgc gctcccccaa tgattaaaat 3286681 attatcaggg ttaaacttag caatttgtct ttcagtagtt tttgttaacg tgtcaggctg 3286741 agtaaataaa actggtgcgt tcagtttttt cgccaatgga ataacaggca atgcatcaat 3286801 aaaaatatct cggttcacca atatcactgt attaggattt ttccactggc tgttggatgc 3286861 aagagtcgca gtttcgtatc gtgaagcgcc tgcaaaacga tccgtaacag caacattatc 3286921 tccagttact ttataaaatc ctgttggcga tagactgatg ctagatttat ttccaatata 3286981 atttaacaat ttaactgaga tgtttgagtc tgctgcaaaa gaaactgatg gaatcaataa 3287041 taagattgca gcaagtgaac acactatcaa ttgtttgcaa gatttcaaaa tttcaggttc 3287101 ctccctatat cttagttggc acgttcaata tcttttaaca gaagctgacc ctcatcattt 3287161 ttttcatatg taatcgtgac cttatctcca ctgttaaact tatcaagatc acttgtcgat 3287221 tcttcagtga tatcaagact aaccggctca ttatctactg ttacttctat tgtatgagta 3287281 tcagctaacc ctacataagt accttctttt gtttcaatgt tactgtctgg cgatacatct 3287341 tcaccttgac tcttttgact attaaccccg caacccgaaa gaagcaatat aaagaacagt 3287401 aaagcaataa attttttcat ttttttcacc tcattatatt ttatcgtcaa cctattttat 3287461 attttaaaga aaaattaaga aacaatgaaa ctttttttta taaaaaacga ctattttagg 3287521 atttcattct tgtattaaat agagttgtat ttattggaaa tttaactcat aatgaaagta 3287581 atttaacaga cgaggtgcaa aggatgagaa acgaacgcag aaaaaagaaa aaaactttat 3287641 tactgacaat tttaacgata atcggacttc ttgtactcgg aactggcggc tatgcatact 3287701 acttatggca taaagcagct tcaaccgtgg caagtattca tgaaagcatt gataaatcta 3287761 aaaagaggga taaagaggtc agtatcaata aaaaagatcc tttttccgtc ttaatcatgg 3287821 gtgtggatga acgcgacggc gataagggcc gtgccgatac gctcatttat atgaccgtta 3287881 acccaaaaac gaatacaacc gacatggtca gcattccgcg tgacacgtat acaaaaatta 3287941 tcggaaaagg cacaatggat aaaatcaacc attcatacgc tttcggcggc acacagatga 3288001 cggtagacac tgttgagaac ttcctcgatg ttccggttga ttattttgtg aaagtgaaca 3288061 tggaaagctt tagagacgtt gttgatacac ttggcggcat tacagttaac agcacattcg 3288121 cgttcagtta tgacggttat tcgttcggca aaggagaaat cacgctgaac ggaaaagaag 3288181 cgctcgctta tacccggatg agaaaagaag atccgagagg cgacttcgga cgccaggacc 3288241 gccagcgcca agtcatccaa ggtattatta ataaaggcgc taatatttct tccatcacga 3288301 aattcggaga tatgtttaaa gttgttgaaa ataatgtgaa aacgaacttg accttcgata 3288361 acatgtggga tatccagtcc gattacaaag gtgcgcggaa acatattaaa cagcacgaac 3288421 taaaaggtac aggcacgaaa atcaatggaa tttactacta ccaagctgat gaaagcgccc 3288481 tttccgatat tacaaaagag ctgaaggaaa gcctcgaaaa gtaaaacaaa aagaagcttc 3288541 gcacaatgtg caaagcttct tttttatttg cctgtaaatg aatccggttg ttcttttcga 3288601 tacccgtaat gaaacagcaa ttcttccaca atccggcggg aagcctctcc atctccatac 3288661 ggattagaag cctgggacat tttcttgtac tcatcaggat cagttaacag ctgttttgca 3288721 agctgataaa tgttttcctc atccgtacct gcaagtttca gcgttcccgc ttccactcct 3288781 tcaggccgtt ccgtcgtatc acgcagaaca agaaccggtt tcccgagaga tggggcttcc 3288841 tcctgcacgc cgcccgaatc ggtcaatata aaatgcgatt tcgctgcaaa gttatggaaa 3288901 tcgatcacct ctaaaggttc aatcagatgc actctgtcag aatcaccaaa atgcttatga 3288961 gccgcttccc ggacaacagg attcaggtgc acagggtaaa cgacttgtac atcttcaaat 3289021 tcccctacaa ttctgcggat ggccttaaac atgttttcca ttggctcacc caaattttcc 3289081 cggcggtgag cggtcaagag aatcatttta tcctcaccca cctgatcgag aacaggatgt 3289141 gagtaaccat ccctaaccgt tgtgttgagt gcgtcaatcg ctgtattgcc cgttacaaaa 3289201 atagagtcgg cctttttgtt ttcttttaat aaattgtctt tcgcctggcc tgtcggagca 3289261 aaatgcaaat cagcaatcgc ccctgtcatc tgtcgattga gctcttccgg aaacggggaa 3289321 tacttattcc ctgtacggag ccccgcctcc acatgaccga cagcaatttg atggtaaaaa 3289381 gcggctaggc ttccggcaaa cgtcgtcgtc gtatcaccat ggacaagcac aatatcgggt 3289441 ttgatatctt taaacaactc atccaatctt acaagtgcgt tagacgtaat ctctgccagt 3289501 gtctgccgct ccttcataat gttcaaatcg aagtcaggct tgatgtgaaa cgcatctaac 3289561 acctgatcga gcatctgtct gtgctgtgca gttaccgtta cataggaatc tatttcagga 3289621 tattttttca attcaagcac aagcggtgcc atcttgatcg cttcaggcct ggtcccgaaa 3289681 acggtcatca cttttagttt tttcatattt gtcacctggt tttctgctat agtaaataaa 3289741 ttcatactac atattctaca tgaaaatgca tcattttaaa tcatttcatt cttgattcaa 3289801 ataaaatgat ataagtttta atattaagga taaagcttgt ttaaaaatgg tttatccgat 3289861 atcataaaaa tgtgtaaaaa catattgaaa agggtaaata gagaatagtt taaccataaa 3289921 ttttttcgat cataaggaag gtgcctttta aatgaaaaaa gtacgtaaag ccataattcc 3289981 agcagcaggc ttaggaacac gttttcttcc ggctacgaaa gcaatgccga aagaaatgct 3290041 tcctatcgtt gataaaccta ccattcaata cataattgaa gaagctgttg aagccggtat 3290101 tgaagatatt attatcgtaa caggaaaaag caagcgtgcg attgaggatc attttgatta 3290161 ctctcctgag cttgaaagaa acctagaaga aaaaggaaaa actgagctgc ttgaaaaagt 3290221 gaaaaaggct tctaacctgg ctgacattca ctatatccgc caaaaagaac ctaaaggtct 3290281 cggacatgct gtctggtgcg cacgcaactt tatcggcgat gagccgtttg cggtactgct 3290341 tggtgacgat attgttcagg ctgaaactcc agggttgcgc caattaatgg atgaatatga 3290401 aaaaacactt tcttctatta tcggtgttca gcaggtgccc gaagaagaaa cacaccgcta 3290461 cggcattatt gacccgctga caagtgaagg ccgccgttat caggtgaaaa acttcgttga 3290521 aaaaccgcct aaaggcacag caccttctaa tcttgccatc ttaggccgtt acgtattcac 3290581 gcctgagatc ttcatgtatt tagaagagca gcaggttggc gccggcggag aaattcagct 3290641 cacagacgcc attcaaaagc tgaatgaaat tcaaagagtg tttgcttacg attttgaagg 3290701 caagcgttat gatgttggtg aaaagctcgg ctttatcaca acaactcttg aatttgcgat 3290761 gcaggataaa gagcttcgcg atcagctcgt tccatttatg gaaggtttac taaacaaaga 3290821 agaaatctaa acaaaaaggc tattggacat tcatccaata gccttttttt atttcaacat 3290881 caaagtcaat gtatgctctt cattatcaac tgcgaagacc tgatcaacgg cctgccgcaa 3290941 aaattaataa tcccagacaa acacactgat tgtagagtta aacaaactaa atgaaaacat 3291001 aaatacaaac atgcagatta aatagtaaat atcttgtatt caatgcaagc taagtaaaca 3291061 ccacttgcta aaagaacaat gactaaacaa ccagcattac aaaataatta aataaatttg 3291121 aagcaattac aacagaaggc agtgaactgt cggaaagttc attttggcta ccatattaat 3291181 ccctttaact acgctgttgg atttatcaag aattgtcggg ctaatagaaa accacggaat 3291241 caaaccagcc agcattcaaa cgataaaagg cacttctccg atacctgtta tgaccagctt 3291301 actgttgcgc atcccaaata caaaccagta cgccatcatt agaataaggg gatttaaaac 3291361 ctgccataat acaccaaaat aattgatttt ttggatcttt cggttaaaga aatttaaaag 3291421 taccagtgaa tattgtaaca aatgttgagt ttttttcact tttaaaaagt aaagagaagt 3291481 ctcgcagaac ttctcccaac atttgaagtg tcaatataaa acaaaccaac ctcatttagc 3291541 aactttatta ttatctaatt ccaaaatagc attataaata cgattcctat tatttttatc 3291601 agtatatgca aaaaagttat ctactctttt tctatactta tcttccatac gactattgtt 3291661 tttcatataa tagataactt tatccactaa gctattatga ttttctaata catcaccaaa 3291721 ccccattttt ttataatcat aataatcaag tttaaaatgg tatgactttt cgtattgata 3291781 ataaataaca ggttttttct catatgcaaa atcaaacgca acagatgaaa aatcagtaat 3291841 cattatatta gaagaattaa atagcatttg atagctgctg ttatagtcgg caaactccac 3291901 ataatcatgc ttttcaaagt ctacaatctg ttgctgaata tctgggtgag gaaaaaaagt 3291961 tattttataa ttatttttct tagcaaattc gattagccgt tcatcattaa tcaaagcatt 3292021 atacctagaa aaatattcac tatctttaaa tttcgggttg tacggtctta ctccttttgc 3292081 ctgatctttc ggtaatacaa tatcttttct ccaagtcggc attattagaa gttgcttttc 3292141 tccctcactc ttcttaagat tatcgtatct cggaaatcca cccaacaaaa tattctcttt 3292201 tttatagttg taattccctt tcacaataga ccgatattca ggtttggcag aagtgactaa 3292261 taatttgata ttcttgttgt atttgtttaa ccattcagaa tgatctgcca ttgttattcc 3292321 gtgctgtaaa aagataaact caaagttaaa taaatctcta aaataaatct ccatattaaa 3292381 aaatggattt acaacccata tatctgcatg tgtcgatatt actttggaag aggataaggt 3292441 taaaatttta tgtctaaaag atctgtatgg tatgaccttt ccatattttt tgattctgtc 3292501 gtaatccttg ctatcttttt ttattataaa gtattttttt accccatcat tcttgttgat 3292561 tgcatattta aagaggtgct cggcattatc atcagctttg tcttgtctgt ctatgaataa 3292621 ccatactggt tttctattaa aaatagtgaa aacatggtgt accattcttg ccatcagtgc 3292681 cttcttaatc gctgattttc gtttttttga tttttcccct gatttatgta gggattttaa 3292741 gaaacgaaac tcttttataa atctattttt aaaattgttt tttttgaaca ttaatttttt 3292801 ataattataa taaaaaatat aatctttttt agccacataa gtattatata aatcgtttga 3292861 caaacctgaa tacttgaaaa aacgaagttt tgtcaacttc ctttttttac ccttagttat 3292921 aaaaaactca atatgatgat tatctgctag atgacctttg ggaatatcta ttgaaaaacc 3292981 gggatatttt tttattactt ctcctaaact tatataatca ttatgctgtc tttttatatt 3293041 ctttgctttt atttttgttt cgccaatttt agcataaaac ttaaaacctt tagaattaaa 3293101 cagcgagctc caaaagcctt ctatgtgaat ggaatcctca ttttcttcta aaatttcaat 3293161 agttaaagtt tgatccgata atttcgaaac aattttacct tctctgtata aataataatc 3293221 ctgttcagtt tctctttcat atacatacct actataattt tcaccgtgct ttatttttaa 3293281 agcatgatat aaatagaaat ggctgacact ttttgtttca atgatgacat cgtcgtcaat 3293341 atacgacaat acttctcgaa tcaatgttaa aaattcactg tattcatttt cgtctaaagg 3293401 tgtttcactg atatccttaa tcaataattt ccacttcaaa tcatgcataa ccatatattg 3293461 aagaaataaa ggtattttct gttcatgatt ttttataata tcgattaaat tctttgagaa 3293521 agtgataagt gaatggttaa accaattctt atttgcttta gcagtctgca tggcagatga 3293581 tccatcttct ctaactctat aatggtattt tgcctcttta accagaccat actttttctt 3293641 ttgcgatatg attaaattaa ctagtttggc atcttcacct attttacaat tttcatcaaa 3293701 cctgatattt ttcaaggcat ctttttttat aaatgtagaa caacaatgag ttaatatatg 3293761 atgcggttct ttttctacat ccaaaattct tgtagaagaa aacttattat ttagattatg 3293821 ttctccagtt cttccttctg caaaaaaaat agggattgct acaatatcaa tttcattctt 3293881 atgttcgtca aagaagttta aaacattttc gaatgttcct tctgaaacta aatcatccgg 3293941 atccaaaaat tgaatatatc taccttcagc atactttaaa ccataatttc gagcactgct 3294001 cactccgcca ttctgtttct ttgcatagac aatgttattg ggatatttct gagcatattc 3294061 tttacaaatg atttcacttt tatcggggct atcatcattc accagtatta actgaatatt 3294121 ctcaaaacca atagtttggt taatgatact ttctatagct tcagtgagat acaactcaac 3294181 attataaatc ggcattataa cactgaaatc atagttaaaa cttttttcgt tcataaaaga 3294241 ttactcctaa cataatgttt atatgaataa gaattcgggt aaataaaatt aagaaacaag 3294301 agagtactaa tttttgcaaa acaattttaa tttagtaaaa tgtatgaaaa gcattcctta 3294361 ccttttttta aaaacccttg taagcaaact tttaaaaatg ttcacatggt taagttctaa 3294421 agaatcattt ggtgttttta gtacaaagtc aaatgcaaag gcccaaatcg gtatttcgac 3294481 aacaaaacca gcatatctaa aatctcttaa tttatatccc catacttcaa ttgttttttt 3294541 cagttctttt cgtttgcatt tttttaatct tttaaaatat tttatatata ttctgtcatt 3294601 ttctttcatc tcataatact ggttaataaa gtgccctgtt aattcaagtc taagcccttt 3294661 tatttttgcc gaagtaacag tacatgaact atgcagtact ctttcttttt ttatattttc 3294721 aagagcttct gtattttctt ttaataagtg aaacataaat tctttatagt acatcggcat 3294781 atcttgttct tttataaatt gcgggtcaat aaattttaaa actttaataa aatcatcaac 3294841 aaaaactctt tgttcttgtt gatctaaaac agacttataa acatctctat agttcggata 3294901 taaaaacagt tttatatgat atacaattaa aaattgcaaa taaggcaaaa ctatatcata 3294961 tttgttgaat gaatccatca acaaagtcat gtaacattca ttcaacaaat atgtgtacct 3295021 ttttttgtta aaccatgaac gatcaactaa agaatcctgt tctttccgtt ttctataaaa 3295081 atactttcct tctgcaactg ctccgtatct tttttctttc agtaataact ggttaaaaaa 3295141 gatagcgtct tcccaaaact ttatagattc atcaaaaagg acggtactag ttagtgtatg 3295201 tcttctgtaa aaagtgccgc caatataaaa atgaatagct ttataatcgt tgagaatatt 3295261 tataactctt gttccttttt caaatctatt atttaattta tgtccccctt ctttttcacc 3295321 tgtgtaataa acaggtaata ccgcaatatt tacatgttcg gaatcacaaa aaaaatcata 3295381 aacactttgc agcgcatttt gagagaatgc atcgtcagaa tcaagaaaac caataaattt 3295441 agatctttcg cttacatttg ataatccaca atttcttgca gcagaaggtc cagagttttc 3295501 aattttcatg attttaatat tattaggata tagattttta aaggattcac aaatttgagg 3295561 actgctgtca acactaccat catctattaa tatcagttct atattttcct taaatccaat 3295621 tgactggtta aggacactct ctattgaata tcttaaataa ttttcagaat tatatattgg 3295681 tataattata gaaaacatgt ttgtacctct ttatttagaa gttaaaggat cgtttcaatt 3295741 actcttttag aagccttgcc tcttctaaat tacaaaattt attataaaaa tcctcatagt 3295801 tatgatctat ataaggatta tgtaacaact cttttaccgt atctataagt tcttcacttg 3295861 tttgaagcaa gtttcctggc gttttttgct gaaaattaaa gtaaaaacct ctgatacagt 3295921 ctctataagc cgggagatca tacacaaaaa atacaaggtt tttttaaaaa ttcatattat 3295981 caaaaaagac agaagaataa tccataatca ataaatcact aattaaatat aaatctcgaa 3296041 tatctttatt taaagaaaca tcgttcacaa aatatttata tttccctaat taaattgttc 3296101 tgaaactgga taataccatt cttacaagaa taaccataga gtctccaagg ttccctcttc 3296161 atttcctcta atcaaattaa agttaaattt atactggcca gctttcttaa aattcattat 3296221 cccgcaaagt tggtgcatat aaaattattt ttctttaatt ccttatttga taatgtagaa 3296281 ttggtagggg attgtagcta aactgtttcc agaatagctt tcaaataaaa ttaatttatt 3296341 gtttcttggc agaaggacaa aaattttaaa caaaactgaa taaactctaa ctagtaaact 3296401 tctgcaattg gttataataa aaatttcatc agtgaactcc ttaaagagtg aagattaata 3296461 tttacgcaaa caagaaaaaa agaagcaact gaatttactt caagcctctt ttagttagtg 3296521 cttctataaa ctagccatat cttttctgat ttgggtagtt gaaatgcctg ctattcttgt 3296581 aaggtaaatg gcctcatagt attcctttgt agacaatcgt acgattaagt aatcccaggt 3296641 tcttttgctc tttccagtag cttcatatgt ccatagtgaa ataaatcaaa cattccgtac 3296701 gtatcacttt cttcattaga taacatcacc ttccaacctt ttccaactta gaaaaaacaa 3296761 aaatccttaa ctgattgttt atcatttcga catatttttt acgttccatt aataataaac 3296821 aataatagca tatgttccta taaaagttaa ggctctttaa aaatgtaaat catcagcact 3296881 ttttgacaat atcgttgcat tgatgtgtat tttttacaga tctgatatct tatctatact 3296941 cattacaaca agttttctat tccggaagag tcaattcttt ttgtcgcgtt ttcaagtgta 3297001 atgattttct ttctgctgcg tcatttattt tgtacgccct cctcatatta cttcatcgtc 3297061 aaaacgtgaa ggaattgtaa tacgtagttc ctaaaaattt tcgtggtaaa atttagtgaa 3297121 gtctttatca ggctaaggga ctttatctaa actacgaatt acatatggag atatatagat 3297181 gaaaaggagg gttgatatga tataaacgaa aatcaattag ataaaggaaa aactgaacac 3297241 ttctgaaaaa agtgataagt ttctttcact atatcctcca aaaagaacct aaaggtcttg 3297301 gacatgctgt ctggttcgcg cctaacttta tcggcgatga gccgtttgcg tttctgcttg 3297361 gagacgatat tgttcaggct gacacaccag ggttgcgcca attaacggat gaatatgaaa 3297421 gaacactttc ttctattatc ggtgttcagc aagtgcctga agatgaaaca cactgttatg 3297481 gcatcatcgc cccgctgaca agtgaaggcc gccgttatca ggtgaaaaac ttcattgaaa 3297541 aaccgcctaa agacacagca ccttctaatc ttgccatctt aggccgttac gtattcacgc 3297601 ctgagatttt catgtattta gaggagcagc aggttggcgc cggcggagaa attcagctta 3297661 cagacgccat tcaaaaactg aatgaaattc aaagagtgtt tgcttacgat tttgaaggca 3297721 agcgttatga tgttggtgaa aagctcggct tcatcacaac aactcttgaa tttgcgatgc 3297781 aggataaaga gcttcgcgat cagctcgttc catttatgga aggtttacta aacaaagaag 3297841 aaatctaaac aaaaaggcta ttggacattc atccaatagc ctttttttat ttcaacatca 3297901 aagtcagtgt atgctcttca ttatcaactg caaaaacctg atcatctgta ttcacaagaa 3297961 aacgcttctt gctgctgtca tacaatacat cgctatcact taaggatagt gacgccgggt 3298021 tgataggaga aatgttatga aaaataagct ctgttgcttt atcattctcc agtacataac 3298081 tgattttttc ataatcaaaa ttcagcgttt ttctgccgtc agccttattt ccttcagtat 3298141 aaccattcaa tttcgattga atgctggtgc tgctgtctcc taggaatttc agaaagtatt 3298201 cataggaaga tgctgcgttt tgcgagacat aagacgtaaa tgcagtggca tgcaattcag 3298261 cgtgtttcat gttagttgca acagcgctct gtttcacata ataagagtgc ccgtcaaact 3298321 ttattttcgc tgcttgtttg ccttttgcag ctaccgttac ttttgtaccg aatggcagtg 3298381 taacgtcagc cttctgtttc aaaccctgat ccttataagc agccgctttt tcatttgcta 3298441 taaacccttg cttattgatt gcagttaagc gttcctctga cttgcccttt gcatcgccat 3298501 gatggttctt cacttcattt tgcggaatag cgccaaacga agcaattgta cgaagcgggg 3298561 cattaaagaa catcgttccc gccatgaaga cagtcagaat agacaaaata gcaatttgaa 3298621 tggcattggc cagtgatttc ggctttttct tctttttgcg gaaacgggca aacgcttcag 3298681 gatcttcttt cttcctctct tctgtctgct cttttttata tgtctctttt tcttttttcg 3298741 atagcttatt aaaccagtca ataaacgctt tgtactcttt cacaaccgtt tttgtttcat 3298801 caaacatacg aagctcgcca tagtgcatcc aagcaacacg gtcacacatc ttttcaatct 3298861 gaccgattga gtggctgaca aagaaaatcg tttttccttg ctttttaaac tcatttattc 3298921 tgtctacaca cttctgataa aacgtttggt cccccacaga aagagcttcg tcaataatta 3298981 aaatgtcagg atcaatatgc acggagatcg cgaaaccgag acgcgacttc atcccgctgg 3299041 aatagttttt aaccggctga ttaataaaat cgccaatctc ggcaaattca acgatgctgt 3299101 catacatatc atcaatttct ttattggtta accccatcat caaacacttg agccggacat 3299161 tgtcccggcc cgttaattgg ttattcaaac cggcagcaat cgcaatcagc gacggctggc 3299221 cgttcatttc aatttcaccg ctggtcggcg gaataatttt agccagcagg ttagacatgg 3299281 tcgattttcc tgacccgttt attcctacaa agccgattgt ctccccttca tacacgtcaa 3299341 aggagacatt ccgcacagca aaaaaaccat tatccttagc cggaaaaaac aatcctttaa 3299401 tcttgtccga ttgtttttta tacaaatgat actgctttga aacatttcga aacgaaactt 3299461 ttagtttcat cgtaaaatct ccttacgtat taaagaaagt caacaaactt gtctctgaat 3299521 ttcatatgca ggatagaacc tactaacaat aaaaggaatg tgaacaacca aaagtacagc 3299581 gtgtacttca tgtcatggaa aaaccatgct ccatctaaga agctgttccg gaatccttca 3299641 ataatataga atagtggatt caacttcaga acaggcacta attcggggtg gctttgaccg 3299701 agtttcgcat taacatccca aaaaattggc aacaagaaaa acaaaagtct tgttacggcc 3299761 tgcagcaaaa attgataatc tctaatcagc acactgatcg ttgagttaaa caaactaaac 3299821 gaaaacataa aagcaatcat acagatgaag taataaatat attgtaacca atgcacactc 3299881 gggaacacac cattaactag gagtacaatg atataaatca ccatcatgat catataacta 3299941 aataagttag atgcaattgc cacggacggt agagaactaa tcgggaagtt cattttagcc 3300001 accatattaa tgcgcttaaa tacactattt gatccatcaa gtatagttgg actgatgaaa 3300061 aaccatggga ttaatcctgc cagcatccaa ataataaaag gcacttcgcc cgctccggtt 3300121 gtcacaggac cgccctttct aatccccata ccaaatacga accagtaggc cagcatttgg 3300181 ataagcggat ttaagaactg ccataagaca cctaaataat tcatttgata tttagacttg 3300241 gtttcataag ccgccaatct taaaattaaa ggaaatgacg ttatttgctc tctgagtata 3300301 cgcaacaaat cattcatttt ttatcttcct tagacttaat tgtttttggg aatctttctg 3300361 tttaaaattt gaaagcaccg ctgattattg taacagatcc tgcatttttt ttcacttctc 3300421 aacaagtatc taaaaagctg ccgaaaaatc gacagctata cattttataa aataacctaa 3300481 attattcagc tttaaataca gtattaacaa ccttttcaga tgaacgtcct gactctaaat 3300541 agcaaaactt atcatagaaa ggaccaaaag aaaccggaag cttataatca ggcgatgaga 3300601 tctgcttgat agcctcaatc gtttcttcag tagtttttac caaaggacca ggagcttctt 3300661 tttcaaaatc aaagtagaaa ccacgcaact tgtcccggta ggtttcgatg tcagggacaa 3300721 agaatagcat tggccgtttt aaatttgcaa aatcaaagaa tactgaagaa taatcagtaa 3300781 tcagcaaatc agaaaccata tacaattctc gaatatcctc ataagcagaa aaatcatatg 3300841 caaatccttc aaaaggacct aaatcaaaat tctcagctac cagataatgc attcttaaga 3300901 ttacaatata ttcatttcca agttcttgtc taagttgatg caaatctaaa tcgagatcga 3300961 acttataacg cccttttgca tagaactgat catctctcca tgtaggggca tataaaataa 3301021 cctttttatc acgaggaata tttaacctac tctttatcaa tgatattgtt tcctcattat 3301081 tatcattatg aagaaaatca tttctaggat atccagattc aatcattgtc ttgttaaact 3301141 gaaacgcccg tgtaaagatc tcagttgaat aaccatttgg ggaaatcaag taatcccaat 3301201 tagaagcttc cttgataaaa ttccttttat attttttggt gtttgtacca ggcatatgga 3301261 cttcttccat atccattgca agtcttttta aaggtgtgcc atgccatgtt tgtaaatatg 3301321 ttgtatgact aggtttcgga atccataatg gaagccggct gttaacaacc caatactcag 3301381 ctcttgccat agcgaagagc cattttaatg agaggcgatt aatgtaagga attccctttt 3301441 catcaaaagg cgctgaatat tgtttattta cactccaata cattttatac tcagggtggt 3301501 tttcccgcat atattcgtaa atcgctctcg gattacaact gtattgtttc ccattaaaac 3301561 tttcaaaaat gactgttttc cttttaactg gcattctgct agccatcatg aatagagatt 3301621 tgtatgtttt agtgattaac ttgtttctca tttttgtgat cttttttatt tttgatacta 3301681 atctcttctt ctttccttta ataaagtatt tcatccttgt tttcaggcta tagtcgttta 3301741 ctctgatacc tagagtctgc tttttctttt tcttaaagac ttcataacga actggtgcgt 3301801 tgtttgtttt aataatactt actaatcctt ttaatttgtt ttttcgatct cctaaaacaa 3301861 gagcagtgct gttgaactga atatccgttc cttcatcgtc attgcatata tactccataa 3301921 aaagacgata aacataacgt ttttcatttg agaaaggaat ttctttcaaa ggcactttca 3301981 cttcaaaatc atacagttcc ggaacaaaac catctgctct catgttttcc aggccatgtg 3302041 tttttctttc tagcttgatt ggaaattttt cctcaatagg tgtttctcca ccctttttta 3302101 aaataaggtt caagtttttt atccgatatt gattttcgga actcaggtac cccgcataac 3302161 ctgttatgct tatttcttca gagctaatct cgatttgatc aaatctgatg attttggcct 3302221 ctcttttcac cttaatagaa aagttgcctt tatcagttgt ataaggtaaa atcaaaagtt 3302281 ctgtggtttg atcgacatga aaggcgcgct caattgaatt tacttcagca gaaagacgct 3302341 tcaagagtgg ttcctgctcc gcatcttcat atttttttcg aaattcgaca taaaaatcat 3302401 atgtttgtcc catttcaaca ggcataggca aaacatgagc atttatctca gttttatact 3302461 ctaatgagcc agtgttttga agcggaaatt cagattccgt tcctgaacgt ctctctttca 3302521 gctttaaaaa taactggtaa tcctctaaaa attggtgttc tgaatcaatt gagattaaca 3302581 attcaagact tcctaaattg tttttcaagc ttttcaaaat acatttaatc acagtgtttt 3302641 caatcattac ttttttctgc tcctctgtat aaaagctctt tcctttttgc ttccttttat 3302701 tagtgtcaac tactaaggac attaactctc ttttatttcc gtgaccctcc aagagaaatt 3302761 gcctttaact gttgtatagg gctctactct atagccatta ttagtatcta tactgtttcc 3302821 tgacaatttt gtttcttcac tcgaaagtct tcgcattgtt ttaatatggc catttgcatt 3302881 gaaaacaata taaaaatcaa taacttgggt tttattagca gctatctttt caatatttac 3302941 atctttttcg agatcaatta caaacagttg atcattttgt aagtttgttg aaataatttc 3303001 agccttattc tttctgtcca agcccactaa acgtattttt ttaatatcat tatgatcaaa 3303061 attctcaatg tcaatttcta ttttagtttt atcaaaatcc tcagtatagg aactaataga 3303121 aggatctttt tttccaacct ttttagagaa cttctctctt tctattcgca cctcaatcat 3303181 ctgattaaga gcaaaagccc aattttcaat atagttgggt cttgaatatt tttcagccat 3303241 tttaaaagct tgttctgaaa atttttgatg agtactttca tctttcatca aagagataat 3303301 agcttgaccc aatttctcta tattatactg ttcaatgaca tatccatttg ctccgtcagt 3303361 aactaagctc cttgctccgt aatcataatc gtatgttaca actggacatc cattgctcag 3303421 tgcctccata tttgatagac cgaacccttc aaaatgagag gttgaaatgg ttagccaagc 3303481 tttttgaaac tctgagtcag ggttatccgt atagcctttc aaaaagacat tgttctgcag 3303541 tttggtatct tcaatttctt tttttatttt ttcgaaatct tcacccgatc cgaatatatc 3303601 aagttttgct tcaggaattt ctttcacgac taaactaaat gcttttactg catgtatcag 3303661 atttttcata gatgcaagtc ttgaaataat gacagctttg tatttttcac tcggcacatt 3303721 caatacagcg ggatcaagag gcttatcaat tgtatgcgga gtaaagaaaa acgtctcttg 3303781 ttcccctgaa atcaatttaa aatcttctag ctgctcctca gttataaaaa agacagcatc 3303841 caaattatac atctgactaa atacttcttt atagcgaccc ttaatttgat atttattgct 3303901 gccgtaatgc ttgttatgaa taattgctcc ataataggaa gaaggtgatt ttttcacttt 3303961 aaagacatgt ttgtcttgcg gtctgctgtc cactaaaaac aacttaggtt tatcattttg 3304021 tttttgcaga tattctatcc aatattgacg cagttccgat tcatctttta cttttatctc 3304081 accctcaagg gagtaccaaa taatatgaga taattgaaca tctttttctt cattgttcca 3304141 tacatagagt ttgtctaaat atacttgatt ttggtcatta atatattcct gcagatacat 3304201 cttgtttagc tgcacatcat aatgagtaac gagaactaag tttccgttct tcgtatattc 3304261 ctctctcttt atgagctggt ttttatcatt ccaatagtcg acgtaccgga tagtttctcc 3304321 atctccgtag taaactacag acatttcatt gttcttctta ccaaacaatc tcaacagagt 3304381 ttttgcaaat ttccccattc caacttgctt ttttatctgg tcaaggccta tcctttcttc 3304441 gtatgatctt ttcccatttg ttctaacact taaaaaatca tcgaatagat taataacact 3304501 tgtgaatttt ttatcaatct taccgttgct gtacaattca tcaatttttg aagacaactc 3304561 taaatcaaaa cgaaacgtta agaaaaaggt gttttggtta cactcttctc caaataattt 3304621 tgaacgcaat aataatgatt tcgtcagacc gccataatta cttggcagtc caccagagat 3304681 aaaataataa tccatgtcag gaatttgttt tatattagat tcactcaccg catgtaaaga 3304741 caatttttta ctccctttcg gcatctagaa tatatgatca ttgaaattta tatctacccg 3304801 gatactttag tcacaaaaat caatgtaagc atcaaaaagt acttcttatt tcaataagaa 3304861 gtactttaat tagatattga accaatgata tcaggatcct aaattataaa ccagcaattt 3304921 cctctttgat ctttgttgta gagatgcctt ctgttcttgg gaggtaaaca acctcacact 3304981 gatctttgag aaagtcaaat ttaccttccc agtcatcccc cataacaaaa acatcaatat 3305041 tatgatcaat aatatcttgc tttttttgct cccaattctt ttcaggaatt acttcgtcca 3305101 catatcgaat ggtttctaaa attaatttac ggtgctcata gctgtgataa gctttttttt 3305161 gcttttgtaa attgaattca tccgttgaaa tagcaacaac taaataatca ccaagctgct 3305221 ttgcacgctc aagcaattta atgtgacccc aatgcagtaa atcaaaagtt ccatatgtga 3305281 taactttttt catttaaaga aacgctcctt cctaatgtta aacactatta aaaacactac 3305341 tgacgttagc gattaaattc taaaaacctg tttgtattcc ttatatcgac atatttctcg 3305401 tatgtcttca ctgatcatta attatagcat accgcctaaa aaaggttaag tactcatgag 3305461 gagaaaaaca ttccaaaata tgtaattaca ctcagactcc attggcacca aggtctgttg 3305521 ttcattcgtt cattcaattg taaaattgga aacatattta aatttaatgt aaagataatg 3305581 ttaatccttt gttgaagatt tatgttaaaa tataaggtag cttgattttg cttttagaaa 3305641 ctctcggttt ttaactatat aaatagaatc ttaaaggaag gaggagccag acatgcaaac 3305701 agagactatt cacaatattc cttatgttaa cagtaactta acatcattta tcgattacct 3305761 agagaaacat tatattgatc aaaagattgg tgctgtcatt tccacagtca accctgaaat 3305821 tgcatttgca gctattaaag atcgggacta ctttgatgta ctatcttctt caaacttcat 3305881 tttgcctgat gggatcggtg tagtcatgat gtcacgtttg actaacaaca ggcttcagtc 3305941 ccgaatcgca ggttacgatg tttttaaaga acttctgggc gttgctaaca aaaagaaaaa 3306001 acgcatattt ctgtacggtg cgaagaaaga tgttataaaa ggtgttgtat ccaaaatttc 3306061 ttctgaatac ccaaacatta aaatcgcagg ttattcagac ggttatgttc aagatcgcac 3306121 cctagtggca aaacaaattg caagagcaaa tcctgacatg gtattcgtag ctttagggta 3306181 tcctcatcaa gagaaattca ttcataacta cagacacttg ttccctaaag ccgtatctat 3306241 aggtctagga ggaagctttg atgtatttag cggtaatgtc aaacgggccc cttcctggat 3306301 gatacgttta aatttagaat ggttctaccg gttaatcttg aatccatggc gatggaaaag 3306361 aatgcttagc atcccaaaat atgctttaac ggttttaaaa gaagaaaaaa acaaaaaaac 3306421 tttctatcca aagcctgaaa aagatcatac aaaacagatt taaaaacaaa actttcaaat 3306481 aaatggatga taaaaatgaa aataagatca ctactggcga attgctattt gtatttttta 3306541 tcagcaatcg ccttttttct gcaatgggtg aaacctgaaa gcaaagtgac cctcctgatc 3306601 tcattcgaag caaacgcaaa agcgattctt gaggaatatg aacaaggaca atactcttat 3306661 aaacttaaca tcctgtatac ccagcaggcc tctgctattg ccgagagctt cccgaatgta 3306721 gatgcatatt tattacaaga aaaaaaccct atccatctca ttaaagctgt atacctaatg 3306781 tttaacagta aagtgatcat aacagataat tactttctat taacaagtgt gttaaataag 3306841 cggaagcaaa cgaaatgtat ccaagtatgg cacgcaaatg gctcactcaa aaaatttggt 3306901 ttggaagaca ttacaaacat gcaacggacg aaaactgata ttaaaaggtt ccaaaaagta 3306961 tacagttcgt atgattattt aactgttggc tcagaagaga tggcaaatat cttcaagaaa 3307021 tcatttggaa taaaggataa ccaattatta aaaataggtg tacctttaac agacccttat 3307081 taccgagaaa acaagaaaaa aatttcagat actctaaaca tacaaagaaa aaaaataatc 3307141 ctctatgcac cgacgtttag agattataat atgcaatcaa ttcaattgcc ttttacagaa 3307201 gaacaattaa ttcatcagtt aaaagaagaa tatgttttat ttgttaagct gcatcccgcc 3307261 attcagaaca atattgatat taaatattcc agtgattata ttaaagatgt ttctaactat 3307321 gccttgtttg atctactcat ggctgcagac atattaatca ctgactattc ttctgttccc 3307381 tttgaatttt cgattttaaa taaacccatt cttttttata cttacgattt aaaactttat 3307441 caacagaagc ggggattggt tgataattat ctttccataa tacctggaag agcctgctat 3307501 gacagtgaat cattaataaa tgaaattcaa accccattta attattccaa aataaaagtt 3307561 ttttccgata gatggaataa gtattctgat gggaattcaa gccaaaattt attgaatttc 3307621 atcgaaaatt taataagcta aatgatgaca cttgttcaaa acagaacaag tgttcttttt 3307681 tctattgaat accgaacgta tgtttgcttt aatgtaatta gttgcttatg gcagcaaata 3307741 ataatagagg tggtaaattt atgagaaaaa aagaactgtt tgatttcacc aacatcacgc 3307801 caaaattatt tactgaacta cgtgtagcag acaaaaccgt acttcaatca ttcaatttcg 3307861 atgagaaaaa ccaccaaatt tatacaaccc aagtcgcaag tggattagga aaagacaaca 3307921 cccaaagcta tcgcataact cgtctatctc ttgaaggttt acaattagac agcatgctgt 3307981 tgaaacatgg aggtcatggt acaaatattg gaattgaaaa ccgtaatggc accatttata 3308041 tttggtctct atacgataaa ccaaacgaaa cagataaaag tgaattagtt tgtttcccat 3308101 ataaagcagg cgcgacttta gatgaaaatt ctaaagaact tcagcgattc tcgaatatgc 3308161 ctttcgatca tagggttaca cctgctcttg atatgaagaa tagacagttg gcaattagac 3308221 aatacgatac aaaaaataat aataataaac agtgggtgac aatctttaac ctggacgatg 3308281 caatagcaaa taaaaacaat cctctttata ctattaacat tcctgacgaa cttcattatt 3308341 tacaaggttt ctttttagat gacggttatt tatattggta tacaggagat acaaacagca 3308401 aaagctatcc gaatctcata actgtatttg attccgataa taaaatagtg ctgcaaaaag 3308461 aaattactgt tggcaaagac ttgtccacca gatatgagaa taacttccgt gaaccggaag 3308521 ggatctgtat gtacaccaat cctgaaactg gggcaaaatc attaatggtg ggaattacaa 3308581 gtggaaaaga aggaaatcgt ataagcagaa tttatgcata ccattcttat gaaaacttca 3308641 tgaatcatgt acctatgctt cgatcccctt tattaaaaac cgtggggcac caagatacac 3308701 ctccagaaag atttcaacca tttattcaaa ccttcatttt agagtataat gctcaaaaca 3308761 aaaaatggat ggttccgact tcaggttatt taccatctta cacatcaaat ttagtccgaa 3308821 atattactat caatgcagat ggaaacttgc aagtcacatt aaatgaacgc tatattagtt 3308881 tactgcatca atcgatagaa ggagatttcc gcttaaaaca aaaggatatc cgaatgggat 3308941 cctggtattt tgccggcgga gaaaaatcaa atgtgcttga aataggtttt atgaaaggga 3309001 gtacaaaaat cagacccgat gatgcagcca tctcaaatgc ttcaagaatg agtattttta 3309061 tgattgttgc ggacaagatt gaggtgtgat aatcaaatag gctgtagcta tttaatagct 3309121 acagcctatt tgcaactttc taagtttttt atcgatattc cggaacatca aaataaagtg 3309181 tataaccgtc cagcaatgaa tacaggctgt acatgcggtt tacttgtttg tacgcccagc 3309241 cgatgtctgt tgcgtattga tgtgtcgctg tagctgacca tctcattttg tacagtgtgt 3309301 cttgattgta agctgtgttg tggatatacg atgagcctat gaatttagct ccgccgataa 3309361 tggccgcttc tggtgtgaac cagccctgct cgtacgcata tttggctccg tagtaattcg 3309421 gattgctgtc gtatgctcca attccataca tgttgtatac ggtttttccg ttataggtta 3309481 atccattggc taaagcggat gtcccgtttc ctgtttccag aagagcgtgt gagattaaat 3309541 acagttcgtt gatgctatat tgattggcgg catcgataaa tgcctttgct ctccctgtca 3309601 ggatgccttt acccgcaagc actttctgat ttacctcagt aacgctgaga cccgctgtct 3309661 gtgacagctt gagaaattgg aagtagtatt tgctgtctct ggaaaagtta ttcggatcca 3309721 cgtattgaac tacttcatca ctgcttgcgt ttcgccagcc caaattgatc ttagcccagc 3309781 cgtttatctg tccgatgact ttcactttat cgcctttttt aaactggccg atcacgtttg 3309841 tcgggctgac ttccggcgtt gaccggatat ttagtacatc agccgtaaca gttgatgttg 3309901 ctgtattaat gtacgtgagc gatacgtaag ccgctccgtc tgtttgcgga cttactgtca 3309961 tttgtttttg gaccatatca cgaagcgaga gattgtagtt tgttttcatg atttgcgggc 3310021 cgtttttgat cttcacgata gatgatgtcc atccgtataa ttgttttagc ttcgttgatg 3310081 ccgcagcagc tgtatcattg cctgtgaact gctcatttac gctgatttta taaagcgtat 3310141 tgcttttcgt tgtatagctc ggggttacac ttttcgattt aagataggtt aacccattgt 3310201 tcaatgcggt tttgctgcta agctgtgttg tcacgatttt gtattgtgta tatgcagtct 3310261 ggcctgtttt tgatgttgtg actgcgatat gattttgttt gaaaaatgtt aaaacgcggt 3310321 caatctcttc ttggctgatg atagcttcag ttgtgatttg atagctgctc gcagctgtct 3310381 gaccggtttt ctggcttgct actgatatat gattcgattt gaaaaacgtg agtgcctgat 3310441 tgactttcgt ttgatcaagc agagattcgg ttgtgatttt aaacgtgtca gctatttgtt 3310501 ttttgacgga tttcgcagaa gcacttagct gatttttctt taatatgttc aaaccctttg 3310561 tgacttttgc ttgatctgat gtttcttctg agatgagctg atattgattt tctgctgttg 3310621 atccagctgc tgtttttgca gcttttactt ttttctgagc aaagaaggct gctgctttgt 3310681 ttgcttgctg ctcgcctaaa atctttgccg tcgtgatttg ataagctgca gacgttgtcg 3310741 tttttttgac gctggatgac gtgtaatgcc attttttctt tttaaagaaa gtgtctattt 3310801 tttggagctg ctgttttgtt atacccttca tattcacggt atatgatgtg ctttttccaa 3310861 cctgttgata actgccggat acgccagtgt ttttcttgat ttggctgatg gcgtccttta 3310921 ctgtactcag ccctttgaaa taagctgatt ggacattgta tgactcaacg gttgtttttt 3310981 gattgatgga cttgtagctg cctgtgatgc cagtgctctg tttcagctgc tgcaatagag 3311041 ttttggcatt ggcttcacct gaaatggcgg cagttgtgaa cgtataatag gcttgccctt 3311101 tcactgtttc ctttaatgat gcctgcagcc cagattcctt ttggaaggcg tttttgatct 3311161 gcgctgctct gctgtctccc acgattgtgc cagactgaat ggttgtgaca gacaccgtgt 3311221 gtgtgatggg ctgatacgag cttttaatcc ccgtttgctt ggccaggctc tggataagcg 3311281 ccttgacttt tgtctcatca gcaatgtctg atgtcatgac gttcatatag ggctgagctg 3311341 ctccgtaagc ttttacagcg ccagccactc ccgtctcctg tttcagcttt gctaggatag 3311401 tgttggcctg tttttctccg gagatggcac ctgacgagat ggtgacatat ggctgtttgc 3311461 ttccaacagg acttgacgtt cctgtaattg atgtctgttt ggcgagtccg ctcagtattg 3311521 ctttcgcttc tgattcgcta tgaatgcctg aggcggaaat ttggtaggtc gttgttgtgc 3311581 ctgaagcctg ataggatgca tcccagccag tatctttttc cagtttggcg acagcttgtg 3311641 aggcttggct ttctgtactg aacgtattcg acggctctac tttatatagt gagtagtcgg 3311701 tatacgcggc tgcctgggca gaaccagaca tggcaaaaaa ggcaagggac gcggcggata 3311761 gaagcatagg tgcgattagt ctctttttca ttccttctcc tctttcttat tctatgagta 3311821 tataaaacta gtttatttat cggcacgcgc atgcttcatt tataggtgaa tcacttccat 3311881 tttctaataa aaaaacttaa cctcgaagtg agattaagtt taaatatgag acacgataag 3311941 ggtacaagtt ccttttatcg taaaatcggg catttgagcc ggcaaaataa agtgatcacc 3312001 ttttttgagc ggacatgttt tgtcctcata cttgagcaaa ccgcttcctt ctatcacgct 3312061 gcaaatcaga aaggattcat cctgagccat ttcagcttcg ccattgatgt cccatttata 3312121 aaccgaaaaa tattcccctt ggacaaatgt tttaatggtt attccttttc ttgattctgt 3312181 cgattcatct atatacccgt ccacatgggg aaccgtggcg gcattgaccg ctttggcaaa 3312241 atgaagctct ctcggacttc cgttgctatc aagacggtca taatcgtaca cccggtatgt 3312301 ggcatctgaa ttttgctgag tctctaaaac aagggccccc ttgcacaatg cgtgcagcgt 3312361 tccgctcggc acataataga aatcacccgg tttaattttg attcttcgca gcaggccctc 3312421 ccagtcaccg ctgttgatca ttgtgacaag ttcggttttt gagcgggccg tatgcccgta 3312481 aatgatttct gcgttttcct tacagtcgat aatgtaccag cattccgtct tgccgagttc 3312541 tccctcttcg ttttctccgg catagtaatc atcagggtga actttaattg acgtatcttc 3312601 cttcacatcc agcagctttg tcagaagcgg aaaccgatcc ccctctacgc cgccgaatac 3312661 ttcacggtgc tcttcccaaa gctcgatcaa tgtctttcct ttatacgggc catttgcaac 3312721 agtgctcggt ccttttggat gagcggaaat ggcccagcat tcccccgttg attctgaagg 3312781 aatactgtat ccaaatctat ctcgtaaagc ggttccgccc cagatttttt ctttaaacac 3312841 aggcgttaga aaaatcggtg attgcgtcat gatccgtacc cctcccctgt aaataactga 3312901 tcatcatttt cccggtgcgc ccctcttaca aacgcccgta taagctgcct ttttcctatg 3312961 acaacatatg tacaaagcat catcttttca ttaccccttc aaagaaaacg cttcctatct 3313021 attatatcac gtcgaaaaga agctttgttt cagccttttc ctcgataaga ataattctcc 3313081 ttttttgata caaattaata aaaaccgtca atatgtttaa gaaggagaga aactatgcaa 3313141 atcgactctg atctccagaa caatttagac acactgaaaa aaacattggg acaaaacgac 3313201 gatatgatgt tttatacatt tgctttcgga gatagcagac aaaaggcgtg tttactgtat 3313261 attgacggtc tgacagagaa taaaatgctg gcgcaatacg tcatttctcc tttacaaaaa 3313321 gaggcgttgg cccataagga atgctcgatt gaagacttat ccgccttttt tttcggcttt 3313381 caccacagcg ttgtttctac aatgaaagaa atagagcagc tcgttttttc agggcaagcc 3313441 attttgctcg ctgatggcta tcgcggagga ttagctttcg acacaaagtc agtcgcaaca 3313501 cgcagtcttg atgaaccctc ctccgaagtc gtggaacgcg gccctaaaat aggatttatt 3313561 gaaaagctgc ggacaaacac ggcgcttttg cgtgaacgga cgagtgatcc taatctcgtc 3313621 atcaaagaaa tgacactcgg aaaaaggacc aaaaagaaaa tcgctgtcgc ttatattcag 3313681 gatatcgccc cagattatgt cgtcaaagaa gtgtttaaaa ggctgaaatc agtcaatata 3313741 gataatttgc cggaatcggg gacgcttgaa cagctgattg aagacgaacc attttcaatt 3313801 ttccccacaa tattaagcac agaacgaccg gaccgggtcg aaagttctct attagaaggg 3313861 cgagtgtcca tattagtgga tggtacgccg tttgctttga ttgtaccggc tacggttgac 3313921 gaatttattc attcgcccga tgattacagc cagcgctgga tcccaatgtc acttgtacgc 3313981 cttcttcgtt attccagcat cctgatcacc atttatttgc ccggtctgta tatttctctc 3314041 gtttcttttc acaccgggct attgccgact agaatggcca tttccattgc aggcagcagg 3314101 cttaacgtac cattcccgcc ttttgtagag gcctttatca tgatctttac gatcgaattg 3314161 attcgagaag ccggattaag gctgcctaag ccgattggac agacaattgg ccttatcggc 3314221 ggcgttgtca tcggacaggc agctgttcag gcgcaaattg tcagtgcgct tatggtcatt 3314281 gtcgtttctg tcacagcact ggcatccttt accgttcctt catacgccta taactttccg 3314341 ctgcggatca ttcggatcgg ggttatgata agtgcaacag cgcttggcat gtacggcgtt 3314401 ataatggttt atctgtttgt gatcggccat ctcatgcgcc tgaaaagctt tggccaggat 3314461 tacattatcc cgatcatggc gcagcctgga caggatttga aagacacagt catccgtatt 3314521 cccacgatgt ttttaaaaag aagaccgaca cgaaacgatc ccgaagataa catcagacaa 3314581 aggtgatggc tatgaggaaa tcagagcata aactgacatt tatgcagacg ctcattatga 3314641 tcagcagcac attgattggt gccggggtgc tgacccttcc ccgctcagcc gccgaaaccg 3314701 gcagtccgag cggatggcta atgatactgc tccagggcgt tatttttatt atcatcgttc 3314761 tgcttttttt gccttttctt caaaaaaaca gcggaaaaac tctttttaag ctcaacagca 3314821 ttgtagctgg aaaattcatc ggctttctat tgaatttata tatctgtcta tatttcattg 3314881 ggattgtttg ctttcaagct cggattttgg gagaggttgt cggattcttt ttgttgaaaa 3314941 atacgccaat ggcagttgtg gtgtttatat ttcttgcagt tgccatctat catgtaggcg 3315001 gaggcgttta ttcaattgca aaagtatacg cttatatttt tcctataacc cttattattt 3315061 ttatgatgct tctgatgttc agctttcgct tgttccagct tgattttatc cggccggtat 3315121 ttgaaggagg ctatcaaagc tttttctctt tattcccaaa aacattatta tatttctccg 3315181 gatttgaaat cattttttac ctggtcccct ttatgagaga tccaaagcaa gtgaaaaagg 3315241 ctgttgctct gggcatcgcg acttccacat tgttctacag cattactttg ctcattgtga 3315301 ttggctgtat gactgtggct gaggcaaaaa cggtgacatg gccgaccatt tcccttattc 3315361 acgcattaga ggttccgggt atttttattg aacgatttga tttgttctta cagctgacct 3315421 ggacagccca gcaatttgcc tgtatgctcg gatcctttaa aggcgcccat atcgggttaa 3315481 cggaaatctt tcatctaaaa aataaaaaca atgcatggct gctgactgca atgctggctg 3315541 cgacgttttt cataacgatg tatcccaagg acttgaatga cgtgttttat tacgggacgc 3315601 ttcttggata tgctttctta attgtgatta caattccatt cttcgtctgg tttttaagct 3315661 ggatacagaa aaaaataggg agggggcagc tgcaatgaaa acagcatcaa aattctccgt 3315721 catgtttttt atgctgctgg ccctctgcgg ctgctgggat gtcaaagata tcgagcaact 3315781 atccttcgcc agagggctgg cgatcgatga gacaaatgat caccagtaca aactgacgta 3315841 tcaaaatctt cttccccaaa gcgaagacag ccaagcatcc ggaaaacccg aatttgttaa 3315901 tgtaacgtcc cacgggaaaa cgattctgga agcagtcagt gatgtatcca tcaaggaccc 3315961 tcctgtttat agcgatcatt taaaagtgat ccttctggga gaaaaactga tgaggaatca 3316021 aaatgtagac caagtcctca accactttat ccgggatgat gagctgcggc gaagcagcta 3316081 tttgatggca gccagaggga atgcagctga tgttttcaca aaaggaaacc ccaatcagca 3316141 gcagccgatg ccctccgaaa aactgattga tttgacaact cacagcggat ataacggtaa 3316201 gattatgata ccgctgcgca tcggaagagc ttctgtctac tctcagaacg ggtacagtta 3316261 tcttattcaa gccgtgaaaa acgaaaaggg aaaagccaag tatgacggag caggcattat 3316321 caaaaggggc agcaataaac tcgttgggtt tctttcagct gatgaaaccc aaacactgtc 3316381 atgggtcatg gggacgatcc aaggcggtgt catgccgacg acagataaag gacatccgat 3316441 tacgtttgaa attaaaaagt cgaaaacgaa aattaagccc gtcattgaaa acggaaagcc 3316501 tgtctttcat atttctgtta aaacgaaggg catcctgaca gaagaccaaa acccgaatga 3316561 aaactccttt agcaaaagtt atttgcacag gctggaaaac atttttgaaa aaaagcttga 3316621 acgagatgta aagcaggtga tggataaact gcagcacgag tataaaaccg atccggtctt 3316681 tttatcagac cacataagga ttcaacaccc tgactactgg aataaagtaa aagggcattg 3316741 ggatgaaata ttttctgaga ctgattttaa gtacgatatt tcttttaaaa tcattaactt 3316801 tggcacggtg ggaaagtaag caatcaaaag ggtgcgcatg atcgcgcacc cttttttatg 3316861 ttccgacagt ctgctgtttt ccggccgctc ctccctgtcc gtttttgtcc cgtaaatcct 3316921 gctcaatttc ttcaaggctt cttccctttg tctctgtcac tttaaatcgg acaaataaga 3316981 acgccatgat accgatcgcg gcataaatca ggaataaata actgattccg atcgcttcca 3317041 ttaatattgg ataggttaat gaaacaatca gtgtcccaac gtgcaacatt aaggtcgaaa 3317101 caccggtccc gattcctctg acgtgaagcg ggaacaattc aggaagcatc acccacacaa 3317161 ccggtcccca gctgaccgca aagacaacga taaacacgcc taaacaaatg acggtcgtcc 3317221 atgaggcagc cggagtgtta tcgaaaaaga gatttactaa agcgagaacg atcaagctga 3317281 tcaccatgcc cgcattcccg aatagcagta acggctttct tccaatcttg tcgatgattt 3317341 taatcgctac taatgtcatg agaacattga ctgtgccgat tccgaccgtg cctaaaatcg 3317401 aagcggagtt tccgaatccg acgtttgtaa aggtctttgg cgcatagtag atgatcgtat 3317461 tcgttccgat aaattgctgc aaaaaagcga gtcccaaacc tgcaataagc gctgggcgca 3317521 cccatggatc gaacagctcc ttcagaccgc cttcatcctg cttttccgct tcttttatat 3317581 catgtatttc ctgatcaata tcttttgtgc cacgcaattt ttcaagaatt ttcttcgctt 3317641 tgctttcttc gccattcgtg aacagccagc gcgggctctc cggcataaac aaaatgccaa 3317701 taagcaagag caatgacggc acagcagcca atccaagcat ccagcgccac gcttcggcat 3317761 cggcaaatat gtaattgaca atgtaagaaa gaaggatgcc gaccgtgatc atcagctgat 3317821 tcagtgatga cagcgccccg cgtttatgtt ttggcgccag ttcagataaa taaaggggta 3317881 cgattgtcgt cgatgttccg actgcaagtc ccaaaatgat gcgaaacagc accatgactc 3317941 ctgtatttgg ggccagtgcc acaccaagac cgcctataca aaacagcagc gcggctgcca 3318001 taattgcttt ttttcttccg aaacggtcag tcagcttgcc ggccgctcct gagcccaata 3318061 tcgccccaac cagcaaggag ctgacaacaa gaccttctgt aaacgcgttt aagcctaact 3318121 cctttttcat aaataaaata gctccggaaa tcactccggt atcatagcca tataacgcgc 3318181 ctccaagagc tccgaaaaaa taaagccata tatttgactg ctttttcata aagatgactc 3318241 cctttctcca tcagctgcaa tgacattgtc tgtgggattt ttttagaaat cttttagcct 3318301 ctttttccgg ccattaaacc tttttatttt tctgatcata agttttccaa tcatttactt 3318361 gtattttttt caatgtcgcc gaaacatttt acctgctgcg gcgtccaata taaggtgatt 3318421 cagtacatta tcgttatcaa ttttcaaaaa caagaactta taaatatagg aatatttatc 3318481 gaaaaatgtc tttcgagtag ttgccccatg gcaaatagaa tggtacgctt caaatattaa 3318541 agaaacgtga ggtattgata tatggaagaa cgatcacagc gcagaaagaa aaaaagaaaa 3318601 ctaaaaaaat gggtgaaagt tgttgccgga ttaatggctt ttttagtcat tgcggcaggc 3318661 tctgtcggcg cctatgcttt tgtaaagctg aacaatgctt ctaaggaagc tcatgtcagc 3318721 cttgcacgcg gagaacaatc tgtaaaacgg atcaaagaat ttgatcctgg aaaagattct 3318781 ttttctgtat tgctcttagg aattgatgcc agggagaaaa acggcgagac cgtcgatcag 3318841 gcaagaagtg acgcgaatgt gctggttaca tttaatcgga aagaaaaaac agctaaaatg 3318901 ctgagcattc cgcgtgacgc ctatgtaaac atcccaggcc acgggtatga taaattcaca 3318961 catgctcacg cttacggcgg cgttgactta actgtgaaaa cagttgaaga aatgctggat 3319021 attccagtcg attatgtcgt agaaagcaat ttcacggctt ttgaagacgt cgtaaacgag 3319081 ttaaatggcg tcaaagtaac tgtaaaaagc gataaagtca ttcagcaaat caaaaaagat 3319141 acaaaaggta aagtcgttct tcaaaaagga acacatacgc ttgatgggga agaagcgctc 3319201 gcttacgtaa gaacacgtaa agcggacagt gaccttttac gcgggcaaag acaaatggaa 3319261 gtgctgagcg ccattataga taaatcaaaa tcattgagct caattccggc ttatgatgat 3319321 attgtggata cgatggggca aaatttaaaa atgaacttat ctcttaaaga tgccatcggc 3319381 ctgttcccgt tcatcacttc attgaaatca gttgagtcta ttcagctgac gggttatgat 3319441 tatgaacctg ccggagtcta ttatttcaaa ttgaatcagc aaaagctgca ggaagttaaa 3319501 aaagagctgc aaaacgattt aggtgtataa tgaacgggat ggcgattacg ccatcccgtt 3319561 ttacatattt ccttgttgaa aattatcaaa gtaacgttta gccttaattt atatggatta 3319621 tgtttcacag gcaagctgaa catactacac gaagcagctt catttttaag gaggttcccc 3319681 tacatatgaa atgtattgcg attgatctag acggaacatt actgaataaa gaaagcgtca 3319741 tttctgcgga aaacagagag gcgatcaagc gggccgttga tgccggcatc ctcgtcacca 3319801 tttgcacggg aagagcgaca tttgatgtaa aagcgctgct ggatgacttg gacatcccta 3319861 tcattgcagc taatggcggt acgatccacg acacgggtta ccgtttgatc agccggacat 3319921 taatggatca ggaagccggt aaagcgattg ctgattactt actttcaaaa aacatttact 3319981 ttgaggtata tacagatgac catctgcttt ctccttttga cggcgaagct aagctgcacg 3320041 cggagcttga cattctaaag agcgcaaacc caaacgagca gacggatgac ttgtggcaag 3320101 gagccatgac tcaattcaaa cagtttggca ttaaaccaat ccctcatatc gaatcggttt 3320161 ttgacggcgg tgaaaacatt tataagcttc tttgcttctc ctttgatatg gacaagctga 3320221 aacaagcgaa ggaagaactg aagcatcata aaaaactggc gcaaacctct tcaggaaaac 3320281 atattatcga aatcctgccg gcctcgtcag gaaaaggacg cgcgttaaca aagctggctg 3320341 acatatacgg aattgaaaca caggatatct atgcgatcgg cgatagtcca aacgatttgt 3320401 ccatgtttga agtcgccgga caccgtatcg ccatggaaaa tgcgattgat gaattaaaag 3320461 aaaaaagcac ctttgtcaca aaaagcaatg acgaaaatgg tgtggcctac tttatagacc 3320521 agcttctttc ggggcaatat gcataaagaa aagactccag agattggagt ctttttcttt 3320581 tattgcaccc gtatacttcc tgcgtattta tccttccaat atgtgctcgt gttcatattg 3320641 gtaatggtca cgccgtttga taatgtgaca tgaacaactt gtccgtttcc gatatagatg 3320701 gagggattta agcttgttga ttgaaagaac acaatgtctc ccggcttcag gtccgccttc 3320761 tcaatcttag ttccggcatt gtactggctt gttgcgtatc gaggcaggga aataccggct 3320821 gctttctggt atacatattg gacaaatcca gctgtatcaa atcccgtctc aggtgttact 3320881 ccgccctgtt tgtaaggcac ttctccgaca taaagcgtcg cttcggaaac aatcggattt 3320941 tctttcggga ttgtcaggtt gtcaaatcgg cgaatacccg tcatcttcga tttccagtaa 3321001 tcctctgaca aataggaaat ggttactttt tctgaccggc ttgcctgaat gaacctgcct 3321061 gcgcccgcat aaatgcctgc atgtgaaatt cccgttttat acgtattgct gaaatagacg 3321121 acatcaccag gctttatgtt ctgaggggct accttctcgc ccactgccca ctgctgttcg 3321181 gctgatcgcg gtagataaat gccgagtgcc tgttgaaaca catattgcac aagccccgag 3321241 caatcaaagc cctctgacgg cgtgcttccg ccaaacacat atgggacacc gatatatttt 3321301 tcggcctcct gaacgacagg aacatcagcc gttgccggat cggcagcgat tcgtctcgcc 3321361 ccgatataag ttccgctcca atagctgctt tttttgtaat tggtgatgat aacccctttt 3321421 gactgtgtac tgtgaaccat ttggccgtct ccgatataaa gggcgtcatg tgtcggaaca 3321481 gtgccggtgc ttccctcttt cttgaaaaac aaaatatcac ccggcttcag gttttccggt 3321541 tttacagctg ttccgatttt atactggtcg tttacagatc tcggcagatg aatatcagcc 3321601 ttactgaaca catattgtat caatcctgat ggatcgaaac cctctttcgg cgtttccccg 3321661 ccatatttat actgatatcc aagcaggttt tttgcttcgc tgacaatcaa ttctgatgat 3321721 gtatcagctt ccgcaatctc cgcttttgtc ataattggaa ccaaaaaaca aatgataacc 3321781 gccacaagca aaaacttctt ccagtttgcc agtgtgttca cttttattat ctcctcctct 3321841 ttttgcagtt ttaacatcgg tatttttttg aatatgttaa gagacttttt aatattttta 3321901 cagaatgaat atgctgggca aataaaaaga gagtgtctca tcagacactc tcttttttga 3321961 attatttatt ggcgtttacc ggttcttcct gctgctggat tttattcatt tccatatcaa 3322021 tcttctgttt ttcctgatct gtcagctgat cattgaattt aaaagctgac ataaacatga 3322081 acacgatggc tacggcaaca aacggccaga tggctttgac aaatttcatc tttatcactc 3322141 cgattattta gattttagtt tgtcactatg atcaatatca aacgtcagtt ttccgtcttc 3322201 tactttccaa gcgaaattag agtctttcgt cagttcgcga ataatggttt tctgtttaag 3322261 gctgtctttt ttcacaggcg caggtgtcgc ttcatggata tcgatcggtg tcacttcaaa 3322321 gcgtcctgtt ccatttttct tcaggtgata ctgaaccagt gcactgtctc ttgttctcgt 3322381 ccagccttgg tcaaagacaa agttgccgag gctgtagaaa atgacggttc cgttatatac 3322441 ttcaatcggt tctaagacgt gcgggtgatg gccgacgatg atgtcagctc ccgcatcaga 3322501 catggctctt gcaagctggc gctggcggtc atttggatca ttgtcatact cttgtcccca 3322561 gtgtgactgc acaacaacaa tgtccgcatg ttttttcgct tctgaaatca tagggatgaa 3322621 gatttcagga tctgcgggca gcacgcccgg cgtattcttt ttagccgcga aacctttccc 3322681 ggacacatcg gtaaagccaa gcgtcgcaat cgttaccccg ttgactttct ggtacgaaat 3322741 tttctttttc gcatcactta agctgtatcc cgctccaacg atatcaagat tttgcttcgc 3322801 aaattctcca agcgtatctt tcatgccctg aacgccgtaa tccattgcgt ggttgttggc 3322861 gctgttgaga accgtgaaat tcatatcctt caagactttc actgattcct tattcgtctg 3322921 cagatgaatc tctttatctg cttgtttata attcttttga taggttaccg ggttttcaaa 3322981 gtttcctgct acataatccg aggctctaaa gatcggttca acatattgaa aaatactgtc 3323041 tgcccctttt tgctccgtta ctttttcaac atagcgtccc atcataatat cgcctacaaa 3323101 tgaggctgag agtacgtcgt cagaatacgt tttgaccttc ggcgtttccg cttttcccgc 3323161 ccacatgaaa gcgaacataa ggacaaaaac gatcggaatg gcaataaata cgtgcttatt 3323221 ggttttcttt ttttgctgtt ttgtcagctt tagcagcttt tcatgaaagc tcagttcttt 3323281 tttcatcgtt tgacacacct tacattaaat taagtagtaa acaaacatga tagcaaaggt 3323341 cgctccgctc aatagcagcg tgcttccgaa cgtaatggtt aaaccttgtt tctgaatggt 3323401 attggcaatt aaacctggca cgatgatgcc gattcctcga aattctgcga tttcaaatgg 3323461 tacaatcggg tatagaaaat caaacgcgat ttttaggacg atccctgtta tcagcatggc 3323521 agcgaatttt ctgcgtccgt acaaaatcat aaatttggat aaaccgtatt tcacaatgac 3323581 atacgtgagc aagctcacta gcaaaacaag taaaataaag accggctgat taaacacaag 3323641 tcctaaatat cccggtacaa caagtcctgc cggcacgatc cctgtttttt ccgcaaaaat 3323701 taaactgagt agtacaccta aaattagtgc gatgtataaa tctgatccga acatgtctgc 3323761 atttccccct agcttacgag ctgctttacc ttgtattcgt ggattttttc aattaaaggc 3323821 tctgcggcac catgaatatt gccgacgcca tatatgacac ggttgtgcat tcttttcttt 3323881 aacaattcca taatttcatc tgttgactta tactctagat catgcagttt gtctgcagga 3323941 attttgcctt cttcgtaggc ttttacgatc ggttctgttg tttcaccgat taagatcagt 3324001 tcacttgctt caatataagg caatacgtca tttgcgaatt gctgtgtccg atcgacacgg 3324061 tctgcgcggc agttcatgat gatgatcgga tcatcggtcg ggtaaccgat ttcttttaca 3324121 cgtttccata tattcaaagt agaagaagcg tcgtttgcgg caaacccatt aacaaagtgc 3324181 ccaggctcgc tcggactgat cagcggaaga attctcattg ctcccggatc tggcggcgca 3324241 ttcagcattc ccttaaatgc tgtttcttcg tcaatgccga gtgcttgagc cacacccagc 3324301 gccagagaag cgttatcagg gaataccatg tattcaaatt tacgtaaata ctcatctgta 3324361 atttttgagt tatcagcaat gatgactttt gtgtttcgtt cttttgcttt ttgtttaaag 3324421 aactcggtat attcactatc tgtaatgaca agatggccat tataaggaat tgtagcagta 3324481 aacgcttctg caatttcatc aagcgtcggc cccatgacat ccatatggtc ttccaaaaca 3324541 ttcacaatga cgccgatatt ggcctgcaga agttcttcct gaaagatgat ttgataatct 3324601 gggttaacag ccatgcattc actgacaatc gcgttagccc ctctttctac tgtttctctc 3324661 atgacttctt tttgctctcc gatattcggc ccctgaggtt tccgtttaat cggcttttcc 3324721 tccggtgtgt cccagtaaat cattcttgca tctgttcctg ttgtttttcc aacagtcttg 3324781 taaccggctt ctattaatat tccggttgtc agccttgtca cagtcgattt tccgcggatg 3324841 ccgttaatat tcacccgaac agggagggca tcaatgtttt tctgatgtcg tcgtttttct 3324901 aatattccga tgaccagtat gacagcacag gctataatga gtaaccacat tgcttttcga 3324961 catctccttc tatattgttg taaattcatt catcagtata tagaatcact atgaattctc 3325021 aatcggcatt atgtaacata atcttcccta atcgactaag ccaaacttct cttttgaaag 3325081 agattttata cctacaaact gttttctatt tttggaaaac agcaggactt ataccttatc 3325141 actttttaaa aaaatcaaag agaatgcgct ttcatttttc tcctgatatc cttctggacg 3325201 tatagtcaca ccctgctgtt tgtatttaat atgcatttca aatcaatctt tttttcagcc 3325261 tttgttatca agcatttcct gctatcatgc gtgtttccgg ttcttatgaa cacaaaataa 3325321 ttttatcctg tttcttaagg acaaggtcat aatgtcatcc tttctgcatg gaataagcaa 3325381 tatgaggccc attccaaaat gactaaggag gttcgagatg aaaacgctaa acatacgagt 3325441 ccgaattctc taacataatt aaacattttc tgggatgata gtcttttctg tttctcccca 3325501 tttacaggtc taaacgcatg actttgaaac aattttaata aaacttaata tttgttcaag 3325561 aaatcttcat ccatatttgt gaagactttg tcaaaaaaag agtgaaaacc ttaaattttt 3325621 caattatata tacaatttac aattagattt cttttgatat ttttattgct aacttcggat 3325681 tgttcatgat aatctatcta tgtaaacggt tacataaaca aggaggagct gttttggcta 3325741 caattaaaga tgtcgccgga gcggcgggcg tttcagttgc gacggtttcc cgcaacctga 3325801 atgataacgg ctatgtacac gaagaaacgc gaacgcgtgt catagcggcg atggcgaagc 3325861 tgaactatta cccgaatgaa gtcgccagat ctctatataa aagagaatcc cgactgatcg 3325921 gacttttgct cccggatatc acaaaccctt tcttccccca gcttgcccgc ggtgcggagg 3325981 atgaattgaa ccgggaaggc tatcgcctta ttttcggcaa cagtgacgag gaattgaaaa 3326041 aagaacttga ataccttcaa acctttaagc aaaatcatgt cgcaggcatt attgccgcaa 3326101 cgaattaccc ggatctcgag gaatacagcg gcatgaatta tccagttgtt tttctggaca 3326161 gaacgcttga aggggctcct tctgtgtcca gtgacggcta tacaggagta aagttagccg 3326221 cccaggctat cattcacgga aaaagccagc gcattacgct cttgagagga cccgctcacc 3326281 tgccgaccgc tcaagaccga tttaacggcg ctttggaaat cttaaagcag gctgaagttg 3326341 attttcaggt cattgagaca gcttcatttt caattaaaga tgcacaatcg atggcgaagg 3326401 agctgtttgc ctcttatcca gcgacagatg gtgtgatcgc gagtaatgat attcaagccg 3326461 ctgccgtttt acatgaagca ttgcggcgcg gaaaaaacgt gccggaggac attcaaatta 3326521 tcggctatga tgacattccg caaagcggac ttctgttccc gccactttct acaattaaac 3326581 agcccgcata tgatatgggg aaagaagctg ccaaactgct tttgggtatc attaaaaaac 3326641 agccgctggc agaaacggca attcaaatgc ctgtcaccta tataggaaga aagacgacaa 3326701 gaaaggaaga ttaagatgcg taatatttgt gtgattggta gctgttctat ggatttagtg 3326761 gtcacctcgg acaaacgccc aaaagccggt gaaacggttc ttggcacgtc atttcagact 3326821 gtgccgggcg gcaaaggagc aaatcaggcc gttgccgcag ccagacttgg ggcgcaagtg 3326881 tttatggtcg gcaaagttgg agacgatcat tatggaacag ctattttgaa taatctcaaa 3326941 gctaacggcg ttcgcactga ttatatggaa ccggttacac atacggaaag cggaaccgct 3327001 catattgtgc ttgctgaagg cgacaacagc attgtcgttg tcaaaggcgc gaacgatgac 3327061 atcaccccag cgtatgcgtt aaacgcgctc gaacagattg aaaaggtcga tatggtgctg 3327121 attcagcagg aaatcccaga agaaacggtt gatgaggtgt gcaaatactg ccattctcac 3327181 gatatcccga tcatactaaa cccagcaccg gcccgcccgc tcaagcagga aacaattgat 3327241 cacgctacct atctgacgcc gaatgaacac gaggcttcga ttttattccc tgagcttacc 3327301 atttccgaag ctctggcgct ttatccggca aagctcttta ttacggaagg aaaacaaggc 3327361 gtccgctatt cggctggcag caaagaggtg ctcatcccgt ccttccctgt agaacccgtt 3327421 gatacaaccg gagccggtga tacgtttaac gcagcatttg ccgtggccct ggctgaggga 3327481 aaagacattg aagccgcatt gcggtttgcc aatcgtgccg cttccctttc tgtctgctcc 3327541 ttcggtgccc aaggcggaat gccgacaaga aatgaagtag aggagctgct gtcatgaaaa 3327601 aacacggtat actgaacagc catcttgcca agattttagc cgaccttggc cacactgata 3327661 aaattgtcat cgcggatgcc ggactgccgg ttcctgacgg cgttttgaaa attgatcttt 3327721 cactgaagcc gggccttccg gctttccaag atacagcggc agtactggct gaggaaatgg 3327781 cggtcgaaaa agtcattgct gcagctgaaa taaaagcatc caatcaggag aatgcgaaat 3327841 ttctagaaaa tcttttctct gaacaagaga ttgaatacct ttctcacgag gagtttaagc 3327901 tgctgacaaa agatgcaaag gcagtcataa gaacaggaga attcacacca tatgccaact 3327961 gcatcctgca ggcaggtgta cttttctaga aaggaagatg aaacatgcag attgaaatga 3328021 aagacattca taaaacattc ggaaaaaatc aggtgctgtc aggcgtttcc tttcagctca 3328081 tgcctggcga ggttcacgca ttaatgggag aaaacggcgc cggcaagtcc acgcttatga 3328141 acattttgac aggcctgcac aaagcagata aaggtcaaat cagcataaac ggaaacgaaa 3328201 cgtatttttc caatccgaaa gaagcggaac agcatggaat agcctttatc catcaggaat 3328261 tgaatatctg gccggaaatg accgttcttg agaatctatt tatcggtaaa gagatatcct 3328321 ccaagctggg cgttttacaa acaagaaaaa tgaaagcgct agcaaaagag caatttgaca 3328381 aactttccgt ctctctttct cttgatcaag aagccggcga atgttccgtc ggacagcagc 3328441 aaatgatcga aattgcaaaa gcgcttatga caaatgccga ggtaatcatt atggatgaac 3328501 cgaccgcagc gttgactgaa cgtgaaatca gcaagctctt tgaggtcatt acagcgttaa 3328561 aaaagaacgg cgtctccatt gtctatattt cgcatcgcat ggaagaaatt tttgcgattt 3328621 gcgacagaat taccatcatg cgtgacggaa aaacggtaga tacaacaaac atctcagaaa 3328681 ctgattttga tgaagtcgtc aaaaaaatgg tcggacggga gctgactgaa cgatatccaa 3328741 aacgcactcc ttctctcggt gacaaagtat tcgaggtgaa aaatgcttcc gtaaaaggga 3328801 gttttgagga cgtcagcttt tatgtgcgtt ccggtgagat cgtcggtgtt tcaggattaa 3328861 tgggagccgg ccggacagaa atgatgagag cgctgttcgg cgttgacagg ctggacacgg 3328921 gtgagatatg gatcgctggg aaaaaaacgg ctattaagaa cccgcaggaa gccgtgaaaa 3328981 aaggtctcgg ctttattaca gagaatcgca aggatgaagg gctcctgctc gacacctcga 3329041 tccgcgaaaa tattgccctg cccaatctgt ccagcttctc accaaagggt ctcattgatc 3329101 ataagcggga ggctgaattt gtcgatctgt taatcaagcg cctcactatc aaaacagcat 3329161 caccggaaac gcacgcacgc catttatcag gaggaaacca gcaaaaagtg gtgatagcca 3329221 agtggatcgg catcggaccg aaagtgctta tcttggatga gccaaccaga ggtgtggatg 3329281 ttggcgccaa acgagagatt tatacgctga tgaatgagct gaccgaacgc ggtgtcgcta 3329341 tcatcatggt gtcatcagag cttcctgaaa ttctgggaat gagcgatcgg attatcgttg 3329401 tccatgaagg cagaatcagc ggcgaaatcc atgcgcgaga agcaacacaa gaacgaatta 3329461 tgacacttgc cacgggaggg cggtaatatg aaaacggaac aactgcaaac agaacaaaaa 3329521 cggattcact tcgacggagt catgcaaaaa ctcggcccgt ttcttggttt atttattctc 3329581 gttatcattg tatctatttt aaatcccagc tttcttgaac cgctgaatat tttaaacctg 3329641 cttcgccagg tcgccattaa cggattaatc gcgttcggga tgacctttgt tattttgaca 3329701 ggcggcattg atctttctgt tggcgctatt cttgccctgt ccagtgcttt agttgcgggg 3329761 atgattgtgt ccggtgtcga tccggttctc gcgatcatcc ttggctgtat cattggtgcc 3329821 gtactaggca tgatcaacgg attattgatt actaaaggaa aaatggcgcc ctttatcgcc 3329881 acgcttgcga ccatgactgt gtttcgcgga ctgacgctag tgtatacaga tggaaatccg 3329941 attaccggac ttggcacaaa ctacggtttt cagatgttcg gacgcggtta ctttttaggc 3330001 attcctgtac cggcaattac gatggttctt gcctttgtca tcctttgggt gcttcttcat 3330061 aaaacaccat tcggacgccg aacgtacgct atcggcggca acgaaaaagc cgcgctcatt 3330121 tcaggcatca aagtgacgcg cgtgaaagtg atgatctatt ctttagccgg gcttttatcc 3330181 gctcttgcag gtgccatatt gacttcccgc ctgcattcgg cccagccgac tgcgggagaa 3330241 tcgtacgaac ttgatgctat cgcggcagtc gtcttaggag ggacaagtct ttccggcggc 3330301 cgaggacgca ttgtcggcac gttaatcggg gtgctgatca tcggcacact taataacgga 3330361 cttaatctgc ttggcgtctc atcattttat cagctggttg tcaaagggat tgttatctta 3330421 attgcggtat tgttagaccg caagaagtca gcttaggagg gttttacatg aaaaaggctg 3330481 tatccgtcat tttaacgtta tcattatttt tgttaaccgc ctgttcgctt gagcctcccc 3330541 aatgggcaaa gccatcaaac tcggggaaca aaaaggaatt caccattggc ttgtccgtct 3330601 caacgcttaa taatcctttt tttgtctcat taaaaaaggg tatcgaaaaa gaagctaaaa 3330661 aacggggaat gaaagtcatc attgttgatg cacaaaatga ttcatcgaaa cagacgagtg 3330721 acgtggaaga tttaattcag caaggtgttg atgcattatt aatcaacccg actgattctt 3330781 cggcgatctc aacggcagta gaatctgcaa acgcagtcgg tgtgcccgtc gtaacaatcg 3330841 atcgatctgc ggaacaagga aaagttgaaa ccctcgttgc ttccgataat gtaaaaggcg 3330901 gtgaaatggc cgcggcgttt attgccgaca aacttggaaa aggagcaaag gtggcagagc 3330961 ttgaaggcgt ccccggcgca tctgccacac gggaacgcgg ctcaggattc cataacatcg 3331021 cagaccaaaa gctccaagtt gtcacaaaac aatcagctga ctttgaccgc acgaaaggcc 3331081 tgactgtcat ggaaaacctg ctgcagggac atcctgatat ccaagctgtt tttgctcaca 3331141 acgatgaaat ggcgctcggt gctctcgagg caattaacag ctcggggaaa gacatattgg 3331201 tgatcggttt tgacggcaat aaagatgcgc tcgcttccat taaagacaga aagctgtcag 3331261 ccaccgtcgc tcagcagcct gaattaatcg gtaaattggc tacagaagca gcagatgata 3331321 ttttgcacgg gaaaaaagtg caaaaaacaa tatccgcgcc tctcaaacta gaaacacaaa 3331381 aataattgtc tgatgtttag gaacctgcga taacgtgaat agagatatag aatgaattat 3331441 ttctcttacg tgaggagagg aacggcatga acaaaccaac aaaactattt tcaacattag 3331501 cacttgcggc tggaatgact gcggcggctg ctggcggcgc tggcacgatc catgctcaac 3331561 agccagaaac aacggtaagc attgatgatt tatacagtta tccgattgat tcttatttgg 3331621 tatcagcaga ggctctaaat gtcagaacga agccttccgc atcaagccag aaagccgata 3331681 cgctgcactt aggagatagc ctaaagctga tttccttctc aaatgctgac tgggcaaagg 3331741 ttaagtataa aaatggaaaa acaggatttg tatccactca ttacattgtt aaagcagcga 3331801 caacggtaaa aaccaaaaca aaaacaaaag tgtatacatc cgctgacgga aagagcatta 3331861 agactcttcc agcagacaca agcgtttctt ttttaggctg gagtaaaacg aataaaggcg 3331921 gttttgattt tgattgggta ttcgttgatt acggcggtac gacaggttat atgaaaacaa 3331981 aggatttaca catgacaaaa taactgagag ggattccgca taaatgcgga atccctttta 3332041 ttatgaattg atttgtcaca ttcccaagat atttctcagg aaatattgtc gtatgctgtg 3332101 tcgaaacctt acatgatcat cgacattttt gttcacgcta aaaagcggag gtgtaaatat 3332161 ggatcaattt gaagcagcat atgaatcgta taaagcccgg caaacaactg ccgatcaaga 3332221 aaatgttcca tctggaaaag aagaaattat tgcggttaga agaaatgagg aagacaatat 3332281 tatcgcagtg aaaaccaata caggaagaga gctcgactac cctactgcgc tgtcagaagc 3332341 aaaatcagga aaactcgctc atgttgatgt cttccataaa tacgggcgtg acattttgcg 3332401 aagtgaaccg gacggcatca aggaaaataa cctgtctgag ctgccggatt tttaaacaaa 3332461 tacagccctg ccgtatgttg gacagggctg tattttaaac aaaaggctgc tggatgtatt 3332521 cggctaaccg ttttgcactg tgagaaatat cctctgcagc tgcataattc acgccataga 3332581 acacatatgg aggcagatac ttcatgccga tcagattact cgtggcctga aatggtttca 3332641 atagctcact gatcgagtaa tgatttgctc cgcccgcttg atatttttcc gcttcgctcc 3332701 ctgttgatac agccagcatc agctccttgc catgcaaggc atttccttct gaaccaaaag 3332761 cccagccata agtcagcaca agatcctgcc attttttcaa gagcggcgga gagctgtacc 3332821 aatatagcgg gaattgaaag acaatccgat cgtattcctc gcacagctgc tgttccttcg 3332881 caacatctat cgcttcatcc gggtattcct tataaagatc ccgtactgtg atattgtcat 3332941 gtttactcaa ttcctcagcc cacgccttat taacaactga ggtctccata tgaggatgca 3333001 ctgccaaaac caatattttc atcagaccac acctttactg ttttgatgtt attttatcta 3333061 aaatcaggaa aagagccaaa taaaaagaaa gccctgctaa aaggggcttt ctttttttct 3333121 tttattcagg gcttccttca gttgtttcga tatctttcgc aaaatcaggg ttatccagat 3333181 tcgcattaaa gaaatccgct gtgttcggaa gtctgagatt catgttcatt ttttgagaaa 3333241 tcgtaaccgt gcaatcctca agcacatagt caaaaacgtg tccgcctgaa ttgcgtcctt 3333301 cgtcaatgaa gtgcaggtga tagccagaaa cggcgattcc gtttgcataa gctggtgtca 3333361 agaaacctac aatcgttcct ctcacgttgt cgaagttgaa aatcggctgt gttttgaccg 3333421 cttcaaccat tggcacgtaa ggtttttctt gaagttctac tgttcttgtc tgcacctttt 3333481 taaacaatcc gtcaatgcga attgcataaa ataagtttct gcttggcagc atgctgttga 3333541 tctctttttc aaagtcttcg cgtgtcattt tcgcatcaat tttgtgcgtc atgtccggtg 3333601 taaagaacgt aaatgaacag aacggtgaac ggtctccatt ttggaccggt gtcgcggttc 3333661 cgtctgagcg aagacggtaa aattcgccgt caaacccaat cagctctccg tcaagcttgt 3333721 taaaggttcc gataccgaag tctccatatt tcggaatctc tgacagttca aaatctccgt 3333781 catatactcc gtctaataga gaagtcattg ttgatacttg ataaatctgg ctcacaggct 3333841 gatctttttg accacggctg agcacttgaa tgttgctttc tcgtttcata tttcccttca 3333901 ctccttttat ttagtgctgt tcataaaaca gtgtcgtgat gcgcagagtg ctagagagct 3333961 ttcgttttca tgagttcccc gaattctttc ggaagcttgt cacttgctaa attaatgtta 3334021 tcactgtagt caaccgggac atcgatgatg acaggacctt cagcgttcat gccttgacgc 3334081 agaacatctg ccagctggtc tggtgattct acgcgcaagc cagttgctcc gaagctttcc 3334141 gcatatttca cgatatcgat atttccgaaa tcgaccgcag atgtacggtt atattttttc 3334201 aattgctgga atgcaaccat gtcatatgtg ctgtcgttcc atacaatgtg tacaattggt 3334261 gcttttagtc gaactgctgt ctctaattcc attgctgaga ataagaaacc gccgtcacca 3334321 gagacagaaa ccactttttc tcccggtttc accaatgaag cgccgattgc ccaaggaagc 3334381 gcaacgccga gtgtttgcat accgttactg atcattaatg ttaacggctc gtagctgcgg 3334441 aaataacgtg acatccaaat ggcgtgcgaa ccgatatcgc aagttactgt aacatgatca 3334501 tcgactgcat tacgcaactc tttaacgatt tcaagagggt gcgctctgtc tgatttccaa 3334561 tctgcaggca cctgctcacc ttcatgcata tattgtttta aatcagaaag gattttctgc 3334621 tcacgctctg caaattccac tttcacagca tcgtgttcga tatgattgat cgtggacgga 3334681 atgtcaccga tcaattcaag atcaggctgg taagcatgat caatgtcagc gataatctcg 3334741 tctaaatgga taattgtccg gtctccattg atattccaga atttcggatc atattcaatc 3334801 gggtcatagc cgatcgtcag aacaacatct gcctgctcta gcagtaaatc gccaggctgg 3334861 ttgcggaaca aaccgatacg gccaaaatat tgatcctcta aatctctaga aagggtaccg 3334921 gcagcttgat atgtttcaac aaatggaagc tgaacctttt tcaaaagctt gcgaaccgct 3334981 ttaattgctt ccggtcttcc gcctttcatg ccgaccaaaa cgacaggaag ttttgctgtt 3335041 tggatttttg ctatggccgc actgattgca tcatctgctg caggaccgag ttttggcgct 3335101 gcaacagcac gcacgttttt cgtatttgtg acttcattca caacatcttg cggaaagctc 3335161 acaaaagcgg ccccagcctg ccctgctgac gctatcctaa atgcatttgt aacagcttcc 3335221 ggtatatttt ttacatcttg aacttctaca ctgtattttg taatcggctg gaatagcgcc 3335281 gcattatcca aagattgatg tgtccgtttt aaacgatctg cacggatcac gtttccagca 3335341 agcgcaacga cagggtctcc ttcagtgttc gctgtcagca ggcctgttgc caagttagag 3335401 gcacccggtc ctgatgtgac taacacgact cccggttttc cagttaaacg gccgactgct 3335461 tgggccatga atgctgcgtt ttgttcgtgc cgggcaacga taatttcagg tcctttatct 3335521 tgtaaagcgt caaataccgc atcaattttt gcacctggaa tgccaaatac atgtgtgaca 3335581 ccttgctcca ctaagcaatc aacaacaagc tccgcccctc tgtttttcac aagggatttt 3335641 tgttcttttg ttgcttttgt caacaccctc actccttatt atgcatttta aacgtaaaat 3335701 tttaaatatc ttgtgataag tttcactata cactctttgg aaattgacct ccaatatcga 3335761 ttcgccttat gattaatatg taatacgaat tattaaccta tggaaaggaa tgcatattga 3335821 atggagcttc gccatcttca atactttatc gcagtagccg aagagcttca tttcggaaag 3335881 gctgcccggc ggctgaacat gacgcagcct cctctcagcc agcagatcaa acagctggag 3335941 gaagaagtcg gagttacgct tctgaaaagg acaaaacgat ttgtcgagct taccgcagca 3336001 ggagaaatct ttttaaatca ttgccgcatg gcattgatgc aaatcggaca aggaattgaa 3336061 ctggcacagc ggacggcccg cggcgagcaa ggccttctcg taatcggttt tgtcggatca 3336121 gctacatatg aatttctgcc gccgattgtc cgggaatatc gtaaaaaatt cccatctgtg 3336181 aaaatagaac tgcgtgaaat atcctcgtct aggcagcagg aggagctact aaagggcaac 3336241 attgatattg gtatacttca tcctccctta cagcatacag ctttacatat cgaaaccgcc 3336301 caaagcagcc cttgtgtttt agctttgcct aagcaacacc cattgacttc taaggaatca 3336361 attacgattg aggatttaag agatgaacca attattactg ttgctaaaga agcatggcct 3336421 actctataca tggattttat tcagttctgt gaacaagcgg gcttcagacc caacattgtc 3336481 caggaagcca cagaatatca aatggtgatt ggtttagtca gtgccggaat tggtatgaca 3336541 tttgttcctt cctcggccaa aaaattattt aatttggatg ttacttatcg aaaaatggac 3336601 caaatacagc ttaatgcaga atgggttatc gcttaccgca aagacaatca taatccgctt 3336661 ataaagcatt ttattcatat ttcaaattgt cagcagacaa gaactaaaga gagtgatgca 3336721 ggtacatgaa caatacttgc aatctctttt ttcttttggg attcttatgg aatttttatt 3336781 aatttaatat aatcgcttag tacaacttta tatcagtata cgtatacata cagtacaaat 3336841 agttggcaag gacatcagta agcgcaggac attagtttga ttttaaaaat gaaagataga 3336901 gaggtgaagt aaattattga gttcaccggc atattcacat tgctcgcttt tttcgtaaca 3336961 atgattttta ttttctggag accaaaagga ctaaatgaag ctatccccgc cacatttggc 3337021 gctttaatgg ttttattgtg cggaagtgtg tcattggcag acttagggga aatcggaaca 3337081 aaagtcacgg gtgcatcggt tacaatcctt gccactatga ttatggccat tgcactagaa 3337141 agctttggtt tcttttattg ggtggctgca aaactgctcc aacaatccaa gggttcaggc 3337201 atcaagcttt tttggctaac caatttgctc tgctttctca tgaccatttt ccttaataat 3337261 gatgggagca ttttgatcac aactccaatc cttttgcttg tactaaaata tttaggttta 3337321 aaaaaacatc aaaaagcccc atatttatta agcggtgttt taatagccac agcctctagc 3337381 gcaccgattg gcgtaagtaa tattgttaat ttaatttctc tcaaaatcat tggaatggat 3337441 ctatatcttc acaccgccat gatgtttgtc cctagtatga tgggactcat ttttatgact 3337501 tgtctactgt ttatgttctt ttataaacgt cttcccaaaa gcctgccaga tataccgggc 3337561 cattttcagt ctctgcggca tagaaggtac catcctcttc attcgccatc agctccttta 3337621 ccagaacgaa atcaaacaaa aatcatgttg tttgtgcttg catttgtttt tctcgtcaga 3337681 atgagtctat ttgcagcatc atataccggt atttctgttc ctctagtcgc tgtcatcgga 3337741 tcttttatcc tgttgagctg gagatggatt tatttcaaaa cctccccaag agacttgtta 3337801 tataaatcgc cttggcacat ttttatattc gcttttacta tgtatgtctt aatttatggt 3337861 ctgcataata ttggattcac agagttactt gtgagttatt ttgaacctgt ggtttctgga 3337921 agcctcgccc atgcaacttt cgcatcaggt atctctactt cagttttttc taatctcttt 3337981 aacaaccatc cagcgttaat gatcagtact tttaccttaa ctgaaatgac cctgaatcct 3338041 tcaacaacaa aaatcatcta cttggcaaat attatcggca gtgatatcgg ttcattatta 3338101 ttacctatgg gaaccttagc aacgcttatt tggatgcata tattaaaaca gcatgatgaa 3338161 agtatttcat ggggcgaata tataaaaacg accattatca tcattccgct gactgttctt 3338221 tttacgttaa catgtttata tttttggatc agttggttat ttctttagca cagtatgaaa 3338281 cgaaaaactg ccttctgctt ttcaagaggg cagttttgta tacactaggg aagatgcatt 3338341 gtctttagat gatttaactt ccaaatgact ggctctccac ttgcgttaat aagctcaatg 3338401 atattattag agacaccctt taatagtccg actttttctg gcacctctcc catatcaaat 3338461 atgaccaatt caccaatatt ttttttgatc tgctcctcaa aattacgcac aagaggaact 3338521 ttggaaggca cgaccggcaa ttgtgagttg tcaagagtat acggtgtttg ttcagttgaa 3338581 taaggggtaa accattttaa atgatgcata gatataaaaa gtattttaaa tacgggtgag 3338641 aaaaatacaa tataatcgtt taaaacattt gtaacatatc catggatcga tcgaccccca 3338701 gttacataaa cttcaataaa ctggcctttg accttgttta atgtatttct atatgaaaaa 3338761 gcttgagttt ctgcctctat cattggatct tccggattga tcaaaaatgg cttctcagta 3338821 ctggtcacta ttttcgcctt gtttatttga tgaagatgca acaagggaat ataaagataa 3338881 ttgcagccat caaaaataac aaaaatatcc tgtccgatat ctatgagggt gccgacaaac 3338941 cttgtatctc ctgaaatgac aacctcaaca tctgtgttaa ggaattgatt caaacctttc 3339001 acgattctcc tcctttaact gaaaaagggc atcactttat ctgatgctcc tccattatct 3339061 attaaaattt acgtttccag tgatagtcta tcgttctgac aatcgtttca tagctataat 3339121 cttccttttg ttttcctgaa ctttttattg aacttgaata gcctggtgat cttgatgatt 3339181 gataatctga agatcttggt gatcgtttag atgattttga tgattgataa tctgaagatt 3339241 ttaatgatcg tttagatgat tttgaagaac tttttgaacg tgacgaacgg ccagatttgg 3339301 atgattgata atccgaagat tttagtgatc gtttagatga ttttgaagaa ctttttgaac 3339361 gtgacgaacg accagatttg gatgattgat catctgaaga ttttagtgat cgtttagatg 3339421 attttgatga gctatatgat tttgaagaaa tgaacgaatt gctgtcctta tcattattgt 3339481 cttcctggtt ttgttcattt ttttgatcct cttttttgta cgaccctttt ggacctaagc 3339541 tgatgctttt tatgtgaaaa ggatagatgc gaagcacctc ttgatttttc actatagtat 3339601 aatggccgtc ggcattatct acaaggatac cctcaatggc ttccggacct ccacgattaa 3339661 ttgaaaccca tttatgagtc agactcttaa aaacctcgct taaatcatca gcttccaaaa 3339721 ctccaactgg cgtctgctct tctattttca aatcaggctc gtgtttactt atacttttga 3339781 tgtgatggat attaaaatac actaccccat cctcatttgt gtttaacgca gcgtaatcat 3339841 ctcccagcca gaccaatctt ccttttttag attccggacc cccttggtta aattgaactg 3339901 attggtttat taaatgtccg attaagctat gaaaatcatc agcatcgagc atttcctcag 3339961 tctcaattgt tgtggtgcta ttattggtat cctcagtaat acttttcaca tgctccaact 3340021 gataataaat tatttttttt tcagcttgta aagctatata atctgatttt acagctgtta 3340081 attttccttt tttagattcc ggacctccac gatatacagt aacaatttta tctttcattg 3340141 agtgcaaaaa gttataatac gatatttcat tatttgaatg atatttcatt ctcctcttgc 3340201 tcattcaaat tcctcctagt cacttataca tagatgataa acatactgca tatatacgtg 3340261 tcacatttat ttgttgaact aattcaatag cctaattgtc gctttttccg cgaataccca 3340321 ttttcacgca ttcataaaat acttaaatga tctttgaggt attgtgaacg gtttttaata 3340381 tactcgcaga tcacatccgg ctcacggtca aaacgctcaa tatcattctt tttatacggg 3340441 tccatgagga caaacggcct aatccgttca tacatcgcca tgattttcgg ttccatatat 3340501 tctattgtaa aaagagattg gagcgttttt tctaacaggc gcttgtagga cttgcgaaac 3340561 tcggattcat ccaatatccg ggcggttagt gtattaaatc cttgaattct tacataatcg 3340621 gcagccatcc gctctccatg gatatccctg ccccaagtcg catcataatc ccaaggaatc 3340681 acctcaaata atccggtttc cccgcttctg tataatgcgt agttgtggac aaacccgtca 3340741 tagttcgagg tgaatacaat accagcaagc cagcgcaaat acttatcgac atccacgtgt 3340801 tttgtcactt ctgacttaaa ctgagcttta gggaccgtat taattttaaa aatcatatct 3340861 tgtaaataaa aatcatcttc ctcagtccct gttttctttt catatccaag ctccagcgat 3340921 gttttcgttt ccctttctaa atcgctcatc agagaaaagt tggcatcatc atccaccgca 3340981 taaaaaatcg cgccatcagc cagcttcctt ttcgccaaat aatattcatc tacggattca 3341041 agttcaagat aaaccccttc attcttccca ttcatcttta caaacgcaaa ctctgccttt 3341101 ggagacagtg tccctagctc cgagaaaaaa tccagagaca atttgtttct catcaaggaa 3341161 gggtctttat actccgcatt taagtgaatc tctcgcgcgc cgcggaatgt tttcggctga 3341221 taaaaggaaa tatggtatga cttctttttg aagtctctga tatgtgatcc ccgataagcg 3341281 atatcaatat ccagcctttt ttgatttacc ttcatcacag ctggcaccgg atcatcgtcc 3341341 catatatcct tttttaattc acgcaagtct tttggatgaa caaacagctg ataaagcggt 3341401 aaattggatt gattcttcat ccataatcct ccttacaaat tttaggcttt tatttttata 3341461 agatctcagc ggaacactta tacacttttt aaaaccgcgc gtactatgag ggtagtaagg 3341521 atcttcatcc ttaacatatt tttaaaagga ggatttcaaa ttgggccact attcccattc 3341581 tgacatcgaa gaagcggtga aatccgcaaa aaaagaaggt ttaaaggatt atttatacca 3341641 agagcctcat ggaaaaaaac gcagtcataa aaagtcgcac cgcactcaca aaaaatctcg 3341701 cagccataaa aaatcatact gctctcacaa aaaatctcgc agtcacaaaa aatcattctg 3341761 ttctcacaaa aaatctcgca gccacaaaaa atcatactgc tctcacaaga aatctcgcag 3341821 ccacaaaaaa tcgtaccgtt ctcacaaaaa atctcgcagc tataaaaaat cttaccgttc 3341881 ttacaaaaaa tctcgtagct ataaaaaatc ttgccgttct tacaaaaaat ctcgcagcta 3341941 caaaaagtct tactgttctc acaagaaaaa atctcgcagc tataagaagt catgccgcac 3342001 acacaaaaaa tcttatcgtt cccataagaa atactacaaa aaaccgcacc accactgcga 3342061 cgactacaaa agacacgatg attatgacag caaaaaagaa tactggaaag acggcaattg 3342121 ctgggtagtc aaaaagaaat acaaataatc taagttttca ttgtttcaat aggctgccgg 3342181 cggaggtacg gaagcctatt tttttatttg ccctgtatta gatatatgtc atgacataac 3342241 atatgcaacc cgcatcattt ggtttccttt aaaccatttc gttataatca aggtatccta 3342301 acgataaagg cggttgttgc tatgtacata tttcaagctg atcagcttag tgccaaagac 3342361 acatacaagc tattgtcagg taccgttatt ccccgcccca ttgcatttgt gacaacactt 3342421 tcttcaggag gagcggtaaa tgccgcgcct ttcagttttt ataacgtcgt cagctcagat 3342481 cctccgcttc tcagtatttc tgttaacagg acggaaggac gccaaaaaga tacagcacga 3342541 aacgcagtgg agaacggaga atttgtcgtt catgtcagtg atgaagccat cattgaagat 3342601 atcaatgaaa cagctgcaag cttaaggccg gatgaaagcg agcttacacg cacctcgctt 3342661 catcctgttg aaagcaaagc tgtttcagtt cccggcatta aggaagcccg cgttcgcttt 3342721 gagtgcaaat tagagcggca tattaccttt gacaatgatc aaggcatcac tacagcagat 3342781 ctgctcatcg gaagagttgt ctgcttccac ctagatgaaa aggtgtatga tgcagaaaag 3342841 ggatatattt taacggatga attaaagcct gcctcacgat tggcgggaaa tcactatgcc 3342901 aagctggggg aagaattcac actgattcgt cccagctgaa gagaaggact atttaaatag 3342961 aagaaactag tcaaaaagac cttatgatta caaaatatcg cctgtaaata actgaaaaaa 3343021 tatcaaaaaa aagaacaccc agagcaagct cggggtgttc ttttatgaaa cgtttttcct 3343081 ttttcttcgt ataaaggtag attaggagga attggaatga caaacttttg gattttaatg 3343141 ctgatcgcta ttaccatcag tctcgcctct caatttttta taaagaaaaa atacggtatt 3343201 gataaatccg gctggcgata taagcatgtc agcaatacac acaaatggat cgaaatcact 3343261 ttacttattt tgtttgtgtt ttcactctcc ttttttccag ttgaatattt gcttctttta 3343321 ttttttattg tgattgactc aatacgtatt tttatggagt ggcattatag acctgaagat 3343381 aaacagtata tgtaccacat tgtagaggtc tcccttatgt ttatgctttt gatttatgtt 3343441 tgtaccctat agttatttaa atccccacag ccgctccgtc tccccgagga tcggctccgc 3343501 cttggagaaa gccttcttca tcaactttga ttgcagccgc ttgtcccatc agcggatcat 3343561 agtcaccgac aacctccacg agatgcccgc tgtctttcag tttttggatt gttttgtctg 3343621 tgaatctgcc ctcgactctg agaccttcgt attcctctcc ccacgttctg ccccataccc 3343681 agcgcggttc gctgattgcc tgctgtggat gcattccgta gtccagcatt cgggtaatga 3343741 tggccgtctg ggtctgcggc tggccttcgc cgccttgtgt gccgtacaga atttttggct 3343801 ttccgccttt acagaccata gccggcatca acgtatggaa ggtgcgcttt ctcggttcaa 3343861 gcgtgttgac atgattttca tccagtgaga aaaacgatcc gcggttttgc agtaatatgc 3343921 ctgtatcacc ggcagtgact gccgagccaa attcaaagta caggctttga atgaatgaca 3343981 ctgcgttgcc atccgcatcg attacggccg catatgccgt atcacttccc accggcctgc 3344041 tttctgccgg tattgcgaga tagccgattt cttctgccaa ttgttttgca taacgtttgt 3344101 ccaaaagcct ttcaagcgga atgtctgcaa acgccggatc agtcaggacg gcatcccgat 3344161 ctagaaaact ctttttcaat gcctccacaa gcacgtgata atactcaaat gaaccgtgtt 3344221 cgatttgggt gaaatcatag ttttccaaaa tgttcagtgt taataaaccg gtaaatccct 3344281 gagaattcgg cggcgcctga tacacactgt atcctcgata atcacttgat acaggcgctg 3344341 cccactcacc ccgatgcgct ttaaaatcat cgattgtcat gtaactgccg ttattctgta 3344401 aatgtgagac aatccgctga gcgagatctc cttcataaaa tgcgcttctt cctttttcag 3344461 caatcaagtt cagactgtct gcaagctctt tttgcacaaa ccgctctccc gggacaggtg 3344521 ctttgcccct tctcgtgaag atgtcagccg tgtaaggcgt ggaagccagc agttcaatat 3344581 tcttttctgt gtgacgacac tgatcagctg atacaggaaa cccattttgg gcataatcgc 3344641 gtgcgggctc caatacatct gcaagagaca gacgcccgta ctccttcagg accgcatccc 3344701 agctatcaac cattcccggc acggtaatag cactgtcaat tccccgcagc ggaatcgcgc 3344761 tttttccctt atatacatct ctcgttacgt tttttcctga acggccgctg ccattgtaga 3344821 cttttactgc ctttgtttcc tggtgaaagg tcagccaaaa ggaatccccg ccaagtccgg 3344881 tcatatgcgg gtacacaacc gcaagacaag cactcaccgc aacagcggcg tcaaacgcgt 3344941 tgcctccctt atccagtatg cggtttccgg cttgagaagc gagataatgc ggactgacga 3345001 ccatttgctt tgtaccgatg acagatttgt tcatcacaag tccccttttt taagaaattt 3345061 tcttcagtat agggagcctg atttttcaca tctactgatc cggcagaaaa actgacgaac 3345121 tttcttcttt tcgcaaataa taagatattt tcgcattcat ttcgaaaaca aatgaaaaat 3345181 tattatttct atacgtaact tttatgataa aatgattgct aaaaggctac gaaagcaggt 3345241 ggagcaattg agtcatgaat atcaaatccc caaccttgta cttgatgaga ctgataaaca 3345301 aattctcacg attttgcatg aagaaggcag aatttcttat acggatcttg gcaaaagagt 3345361 cgatttgtca cgggtcgccg ttcaggcccg tatcaaccaa ttaattgaag ccggtgttat 3345421 tgaaaaattc accgctgtca tcaatcccgc taaaatcggc atccatgttt ccgtgttttt 3345481 caatgtcgag gtagaaccgc aatttttaga agaggtcgct cttaagcttg aggaagagcc 3345541 tgcggtcacc agcctttatc acatgacagg cccgagcaag ctgcatatgc atgggatctt 3345601 taccaacgat caagaaatgg aagaattctt aacaaaacgg ctgtatccat tgcgaggcgt 3345661 cgtcagtgtt gattgccaga tgctgatcaa acgatacaaa agccgtatgg gaatgaagct 3345721 gtaaaggaga gaaacaaatg aaaaaccatc cttatcggga tatgacggcc gcaatggttc 3345781 gcaccggcat attagggttc ggcggcggac cttccgtgat tccgctgatc cgccatgaag 3345841 cggtcaataa atataaatgg attgacgatg atgaattcgg agaaatatta gcaatcgcta 3345901 atgcgcttcc cggaccgatt gccaccaaaa tggctgctta tctgggcttt aagctaaaag 3345961 gcacattagg tgcaattgtg gcgatcctcg cccacattct gcctacatgt cttgcgatgg 3346021 tgggcttgtt tgcggctgta aatgtgttaa gccattcagc aattgttgca ggtatgattg 3346081 gtgccgtcac gccggtaatt gcggtcatgc tcggaatcat ggcgtacgag tttggccaaa 3346141 aagcgcttaa aggtttcggc tgggttaccg gcatcctgtt ttttatcatc gcttttatcg 3346201 gcctgcaaac tttacagatt aatcccggcc tggtcattat cattttctta gcttacgggg 3346261 cgtttcattt taaactgaaa gacaaaatca caaataaaca ttcaaaagat aaaggaatgt 3346321 cagcctcatg atatcgatct atttatttat ggcgtttttt atcgcaaacc tactgggata 3346381 tggcggcgga cctgcgtcta tcccgctaat gtttgaagaa gtcgtaaaca gatacagctg 3346441 gctctcaaac gatcaattct caaatatgct cgcacttgcg aacgcattgc cgggcccgat 3346501 cgccacgaaa atcgctgcgt atgtcggcta cagcgcaggc gggtggcccg gcttcctaat 3346561 tgccctgatc gcaaccgtcg taccgtcggc gctcgcattg atcgtcctgc tgcgcatcat 3346621 ccagcgcttc cgccaatcac ctgtcatcaa aggcatgacg ctgtccgtcc agcctgtcat 3346681 cgcggtcatg atgctcattc ttacctggca aatcggcgca gacggcatca aagcgatcgg 3346741 ctgggtccaa tcgatcgtga ttacgggaat ttcgctcctt gccatgacaa aattcaaaat 3346801 gcatccggca tttttgatta ttgcggcgtt tttatatggg ggccttgtga tcccttattt 3346861 atagaaaaaa gcacctggac aggtgctttt ttattttagc ccagaaatgc cgtttgatat 3346921 gacagctgtt tcttctcctg cgtcactctt gatcatgtgc ttgacttgca gcgtggttcc 3346981 tgccattctc acagattgct tcaactggga cgaattggtt tcaacttgta tccaaacagg 3347041 aggctggacc ttccaaaata aatagagtgc aagaatcagc aagccagcaa tgaccgacag 3347101 caaaaacttc atatcgcatc gcttcttttc agtaagcggc tcgcagcgga cagcgcctga 3347161 tgatcacgaa gaatatcgcc tggacgattg ccttctccca gcacatagcc tttaaaggac 3347221 attcccataa aatgaaaaat atgttcgaat tgctgaatca gcggcagccc ttttattttt 3347281 ggattgtctc cgcccactgc tattacatat gcctgtttca ctgacatttg ctgtttaaaa 3347341 tcaggaaatc tcggatctct caacgtctgt gaccagcgat caataaacag ctttaatgtc 3347401 cctgacatgc caaaccaata aattggggtg gcgaatataa gaatatggca ctgcaatatc 3347461 cgttcaatga tagaatcgta gtcatcttga acaggacgaa agccgccttg ggcgtgacgc 3347521 agatcttcaa ttggttgaat tggatatttc tgcaaataaa tgtgctccgc atcgaatcct 3347581 tgaacagcct tctccgcaag aacatccgta tttccgccag accgagttcc gccgttaata 3347641 accgcaattt tcatgatgca tctgctcctt tgtttacgaa tgattttctt catcatataa 3347701 tggattcatc aatcaataca gatgattatt tcgattaatc caatcgctaa aaccgattta 3347761 gaaaggaaga gaacaagtgg aattgaagca gctgatcacc tttattacgg cggctgaaca 3347821 tgtaaacttc accctaaccg ccaaaatgct taattatgca caatcaagcg ttacctctca 3347881 gatcaaatca cttgaagaag aaatcggaac gcctttattt gaacggctcg gcaagcggct 3347941 tatcttgaca gaagcaggaa aaacgttcaa atcttatgca cagaagatca ttgcgttaac 3348001 agaagaagcg aaaatggcca caaatcaagt aagagaaaca accggaacct taaaaatcgg 3348061 ggcgacggaa agccagtgca cataccgcct gccccctatc ataaaagaat ttaaacaggc 3348121 ttttccccaa gtaaagctca tattcaaacc atatatctcc aatgaacaag cgaaagaaca 3348181 gctcttacag ggccagcttg atatcacctt catcttggat gtaaaccgga tggaagacgc 3348241 actgcacgtt gaatctttga ttcaggatga gatcaaaatg gtggctgcta atgaccatcc 3348301 ttttcctgcg gatttaccag taacattgaa ggatcttcaa aacgaaactc ttctgctgac 3348361 agaggacggc tgctcgtacc gcacgctctt tgagaacaat ttgcatgact ccggtatcta 3348421 tcctaacaaa ttggaattcg tcagcataga agccatcaaa caatgcgtga tggccggact 3348481 tgggattgga atcttgcctg aaatgacagt aaaagatgat attgcagcag gccggatgaa 3348541 agaactcaat tggcagagcg attgccccgt tttcactcaa ttagcatggc ataaggacaa 3348601 gtggatgtct gcgccattaa aggcttttat cgatttgaca cggaaaacat tcaaataaaa 3348661 cctctccaca aggacgacaa ggtttttgag accagggcac acacatacaa aaaaaacact 3348721 tgatgactta gagccccaag tgttacacgt gatttttctg ataaaacgtt cgcaaaacat 3348781 gcgtctcaag gtcagccagg cggacaggga tcggcagcct gctttcttga ttgatcaagc 3348841 tcatcgtgat ctgatagctg ctgtctaaat caatataatt accgcaagac aagaaaatag 3348901 gcttcacgtc ccgccgcgtt cgcagcgccc gtccatatac ctcgccgtca atgataatat 3348961 cggtgtatgc gcctacttca atttcaggcg tcacgaaatc gcagcctttg attttgagat 3349021 aggttttcgc tatcccaatc gtcggcttgc ccagaaaaaa agccgcatgg gtggcaacgc 3349081 ccatatgatt gtaatgcaga tatccgttgc catcaaacaa gaagacatcc ggctccgtct 3349141 ccagcttttt cgccgcctcg atgatcaagg gcagctcgcg aaacgcaaga aaaccggaaa 3349201 catacggcac gctgattctc cccatgctgt gcactttttc aatgacttct tttgtatcag 3349261 cgtcaattac gataatacag cacactccgt atggttctcc atcctgctcc caataggcca 3349321 ggtcgacgcc tgcgcaggtg ttgatggagt ctggatggat cgtgggggat aggttgatac 3349381 gatttttaag gttaaattgc acttgtaaaa agtcttgttc ctttttcata tcaaatttat 3349441 gcacatcaaa taccttcata acgattgctc actctcgacc taaattaatg tgagtctctc 3349501 ttctcgattc tagtatttca aaatgaggac tatctgtatc tatctcgtac ttatttaata 3349561 gattgccttc ttcatcccaa ttcttttcag aaattagtat ggaatgctca tactgttgct 3349621 cacttttttt cctgccattt tcaaaccaaa ttatgcttat accgtgcaat tgcccatatc 3349681 ggtattcttt ttcacttttt ttattcccgt tttcataaaa ttcacatgtt aaaccatggg 3349741 ccagaccatt cttatattta gtaaaataga tgatttgacc atttggatat aattcgtaag 3349801 ccagccctgt aaacggctgg ccattttcgt cttcaggatt atctaaaatc tcatcactta 3349861 ccgaagagaa ccataaatcc tcaaagtcca ctcccttttc ttttatactc ttcatatcat 3349921 attcattttc catactttaa agcctccggt atataatttg tattttgagt tatatattca 3349981 caatgtggac atctaggcat tgggacacct tctggcatct ttttatttat tttcctagca 3350041 cttactacat ataccattaa atcttttaaa tccgcatcag gtctttgaag taacgcttca 3350101 tttagagcat taacttcggc atgagaaccc gcccctgacg tctttatata accttcttta 3350161 agttctgtag gcatatttac aattctatca tgaataagtg gatgtagtac cttaggtggc 3350221 ttcccatcta tattgtttat tccaaaataa taattgcctg tttttttgtc caatacacca 3350281 gctaccgcag ggcctctttg ttttttagtt agaccagaag atttaattct actaagttcg 3350341 tttagtactt ctgcccttag atttattcga tggtgaagat cttctttaga caatacacca 3350401 tgcttatttc ttaaatattg aagcctagtt tgtttttctt cagtagtctt agcaatattg 3350461 ctaataaggc tttcattact cactttattg acatatggag catttttttg gtacaaccga 3350521 tcaaagtagt gtgccaatcc tgctccacca ataatagtaa tagcttccag cgccccttgc 3350581 ttccgcttct cctcagacac tttgtttccg aacatatccc ggcctgtgac agcttctgag 3350641 aatccgtttg acgcaacaag gccgtatgcg cccatttctg tcattttgag aatgtctaag 3350701 gatttgcctg ttttgtaggc gtctaatgcg tgttcagcag cgatagctgc ttttccggtt 3350761 ttgtagatgg cttttccgcc tttgaaggcc cggcctgccc agccgacgac tggtatgaat 3350821 ccggcagcgg ccatagctcc tgctgtcaca cgctccgcgg tggagagttt ttctccggta 3350881 accggatcaa cgccttcggt tgctctttta taatcataat agccagtgac ttctccagta 3350941 aagttgcaaa ctccatccca tgttttttcg taccacggtt tgtttgcttc ttcctcggct 3351001 ttttcctgga gccgtcttgc ttctgcttgc tgggtttttg catcgatata ggttgttcct 3351061 tgattttcta cttcaatgac gcttttgtag acttcattgc tgtggaaggc ttttttgtca 3351121 tagtacatag gggatgcgct cttcccattg ctggtggcct gcatgagaac agaatatttg 3351181 gtgagcactg cgttgtccag agattctaaa ttttgatatt cagtggtcag ggattcatca 3351241 agcttatcga cagctgtgat tgtatcacgt ctgatttttt gggcatcgcc catcttatct 3351301 gcatagtcgt caagcgtgta catgtcgaga tcaataatat cgctgatgcc tgacaaaata 3351361 gaatcgattt cttctttatg agcggagaca atctctgagg ctttcaggtc tccattgggc 3351421 agctcatgat ccaaaaaaga agtttccaca tatgaatcat tcagttcttg atctttaata 3351481 tctcctgaaa tgccgtttaa aaacgcaatt tgagcagaga caagcgtcag ccagctgtct 3351541 acgatttctg cctgtccctg aaaaaaatct ttaatattgt ccgcgccatt tcctttaaaa 3351601 ttatcgccta aatcggcaac tccctgaaac gcttttttca gcgtattcag ctgctcttca 3351661 agcgtctcat attgcttttt tctgctcttc gcttcttcga ttaaagattt tgattcaaat 3351721 actttactca tcgcactgcc ctttctgttc tattttaccg ctatcgcctc gtcctgctct 3351781 ttgagtgaat ctacgttatc ctttgtatcc tcgatatttt tctgtaccgc ttttttgtaa 3351841 tctccgagca tggttttgat gttctcctca cgctcatggt attttttcgt ataatcgagg 3351901 ctgttttttc cgttggatcc tgcggcgccg attgatacgt cagcaagcgc atctttgaca 3351961 gaatctaatg ttttgatgac tgtgtcgtac ttcagcttaa tttctgacat aaaaaaagat 3352021 caccaccatt ttagtttact aattgtattt ccgacttctt ccgcgaactc ttctcccttt 3352081 ttaagaagat ctgctgcacc atttgctatg aacaattccg atgcatattt agctttatcc 3352141 cattcaagat caaaaatttt cccgttaatc gaagccatat actcgttata tttatcattc 3352201 acaatcttag atgcttccga tttcgcctct tctcttccct tgtcgaaatc atcggctttt 3352261 gttcccgtcc aatgcttgcc caattccggt ttcacaattt ctttgatttc agtgattgcc 3352321 tcttcttgca gtgtgtctat gtcctttttt gcttttttca gcttttcgat cttgtcttcc 3352381 acgtctgaaa tttttccgtt gagcgaactt ttgatatccg ctagcatact ttcataaccc 3352441 atctgaatca cctcttaata ctcaaaaagt cgtatggagg ggctgatgaa gatagacttt 3352501 tccatacttt atttccatat attatatttt aaaatagcca gaaggcggct taaatagggt 3352561 aaatggctta atttaggcat ataacgctct tgaaatgtag gtatttgatc ttgtttttgt 3352621 tcgttataca gctaataaaa gcgttttata aaatgaaatc acctaatgtc atagttataa 3352681 aggcacttga aagaggcaga tgttgttgat ctgcctcttt cggcgctgag cttattgttc 3352741 atgtttatgt tcttcatctg gtcggccatg tctgattttg tcatttggct tctattattc 3352801 cccccttctg accctttgga tcaaaagctt gtattagctg cagtcccagt tgtacagaac 3352861 gtttgaaaag tcttttttcc ttagatcttc aggtgtgatg aaaaaattgg cgatgccgac 3352921 gtctccccac attgaatcga tatcatcgtc tgaatcaatt tgtaacagca tgatggtgtg 3352981 ttctttatat gcgtattccc ggggatcatg ctgggtaaaa gaagcgtatc cgccaatttt 3353041 atggccaaat ccgttttcag ccagttcatt ataaatgtct tcttcatcct cgccgaactg 3353101 accaaagaac tccattgttt ccatgcccgt atactgctca aattgaaaat ctgtaggcag 3353161 cacccattcc gaagatttca caggctcgac tgccgcttct gataaaatcg gaaaatcaca 3353221 ttcgcctgtg ccaataaatg aaaaatcaga aacaagctcg tcatcgtttt ctacgatatt 3353281 ttcaaaatag atcactctga aattcttttg ttcacatcga tcgtcaaaat tcaatccata 3353341 gacgtcatca tgaacagaaa tgtagaactg caggatacct gaagaagggt agccgtcaag 3353401 ctggggaatg tgcgagaaat taatctgcgc cagaagtttc atcggctgtc cattttcgtc 3353461 agtcggatat gtttcatgct tggggaaata gggatcaccg gcaattttgc tgtcatatcg 3353521 tcctgttttc ccctttctca cattcagttt cacgtattct ttcgctgatt tctccagcaa 3353581 gtcgcggtac ggtctcattt tttcgggcag atgattcatc agattctctc cttttccggc 3353641 atctccaagg ttttattttc tggttttctt ctaatgtttt tcaaacgaat gtttaaagaa 3353701 gccctacttc tgcataattt tccaaacaat agttaaatag tagcaaatgt attcagcacc 3353761 ccgcaataga tgaaaaaaag actggtgcgc aaccagcctt tctttttcat ctattgaatt 3353821 gcacctgacg gaacaaccgc cttccgtccg acagaataat actccactcc tgcagccaaa 3353881 gcctcatcca atgtgtagca gtttctgccg tcaaatatga gcggcgtttc catcaaatcc 3353941 tgataagccg ctaacgggaa ttgtttaatg tcagcccagt cggttaaaat catgacggcg 3354001 tcagaccctt tgacagcttc ctcgatcgtc tctttatatt caacagcttg cgggagaaca 3354061 tgctttgcat ggctaactgc aatgggatcg taggctctga tacgggcgtc gagcgcagcg 3354121 agacggtctg caataacaat tgacggcgct tctctcatat cgtcggtatt cggtttaaat 3354181 gacaggccta aaagggcaat cgtttttccc gtcaccccac cgagcctgtt cagcgcttta 3354241 tcaaccagca tcgcctgctg attgttgttg actttgataa cggatttcag cagttcaaaa 3354301 tcatgctcga cattgccggc aatttgcacg agggcgtttg tgtcctttgg aaaacaagag 3354361 ccgccgtagc ctatgcccgc ttttaaaaac tggctcccga tccgcttatc ctgtcccatc 3354421 ccgtatgcga ctgcttcaat atcggcgccg accttttcac atatattcga aatttcgttt 3354481 ataaaactga tcttagtggc cagaaaagca tttgaggcat atttgatcat ctcggcgctt 3354541 ctgatatccg tttggtaaat cgggatttga aacggacgga agagctcctc cagcgtattt 3354601 gctgttttct catcggccgt cccgatcacg atcctgtcac catgaaaggt atcatagatc 3354661 gccgacccct cacgcaaaaa ttccggattg gatgcgaccg aaatactgac aggctccgct 3354721 agatgttcag taatcagtcc attaatcaaa tcgtttgtcc caacgggcac tgtgcttttc 3354781 gttaccacga ctgtatctcg tttgacatgc tttgcgatgc gtttggccgc atctgtaatt 3354841 tgctccagat tggcgtgccc gtcgcttttc tgcggtgtgc cgaccgctat aaaaatgatg 3354901 tctgcctgtg ccaagccttt ctcatagctc gtttcaaagt tcagccgtcc atcagctgta 3354961 ttttttctca tcagctcttc aagacctggt tcaaatatgg gggaaatgcc ctttctcatt 3355021 tcatcaatct tgtgagcgtc aatatcaatg caggttacat gatgtccaat ctcagaaaga 3355081 gaaacacctg tcacaagacc gacatagcct gttccgatga ctgttatatt cattgtttcc 3355141 ctccaacagt taaattgctg ctttgcagct tccgtaatat cgtatgagaa catcctatca 3355201 tgaatgcgaa tgatctcccg catagcctgt cgggtacagc ctgtacagat ttctgaaatg 3355261 tgattcaacc atacaataca ctattatatc gctctcaaaa agaaagtggt gaaatgagaa 3355321 tcggctgtta aaaaaaacca aacaattttc ttcttttgac cggctgcgga ggctgtctga 3355381 agatggtctg attccgcagg agaagctctg cattttccgt cagcatataa ggaagttccg 3355441 agccgaattc tttctctaga acataaagag cctcttgagt gtgaaaattt ctcgttttca 3355501 cattatgggc atctgaggct acgaaatgga tcaaattggc ttcaaccagc cggagagaaa 3355561 atgctttcag ctgcttgccg aagatccccg caagacttcc tgaagtaatc tgagatgctg 3355621 ctcctttttc cacaagatga tacagcaagg acgggttttc gcgaatttcc ctgttgcgtt 3355681 caggatgggc gataaccgga atatatcctt tcagctgcaa atcataaaaa agctgctccg 3355741 catatcgggg aacgtgatca aacggaaact caatcaagat gtattttgta tcattcagcg 3355801 aaagcagctg acgtttggca aggtcttgtt ccacctcgcc gtagattctg atttcctgtc 3355861 ccggaagcac atgtaaagga atgtcttctt tgattaaacg tttgtttaac tgatctgctg 3355921 cttctctgac tgcggctggc tcgtttttat acacaccgtt gttatgatga ggtgtcgcaa 3355981 tgatcgtccg gattccctga cgaacagctg ctcttgccat ttctatgctg tcggccgaat 3356041 cacctgcccc gtcatccatt gcgggaagaa tgtgacagtg aatatcgatc atgtcctagc 3356101 cccctttttt cgcaaaaata aataacgggc acgatgcacg ttatttattt ttgcatgaaa 3356161 ttgtccttgg ttccgtaata tccgtattca gagtgcttcg aaagcttttt gccgttcata 3356221 atcgccccaa ggagcttgct tttgcacgtt gcaagcgcct ctttcgcttt tgcggcttgt 3356281 tctttttctg ttttcccgct tgaaataacc agaacagaac cgtctgccac gttgcctaaa 3356341 atctgtgcat ctgctacggc aagaataggc ggcgtatcaa aaatgaccat atcatatgcc 3356401 gcacacgctt cgtatgcaag ctccttcatc cacttcgagg agagaagctc ggccgggttt 3356461 ggcgggatcg ggccgctcgt cagcacgtca agatgttttt cattcgatgc ttgtacagcc 3356521 tgctccatag agcttttctt taataaaaca gatgttaagc caaccgtatt ttcaagaaaa 3356581 aaagccgtat gtactgttgg ttttcgcaaa tcagcatcaa tcaggagcac tttttttccc 3356641 tgttgggcga atacgacagc caggttggcg gccgttgttg attttccttc ccccggacaa 3356701 gccgatgtaa tcatgactga tttcatttgc cggtccactg aagcaaattc tatattcgtg 3356761 cgaatcgtcc gatattgttc agagttcaag gatttcggct ctgtcattgc aatgacattt 3356821 ctctgcatcc gcgagcctct gttttttcta agcgccaaaa tgtccactcc ccgttttttc 3356881 agattggaaa ccctgtaagg tctttgctgt tttctgctca ttcgcaatgg tggaaactgt 3356941 ccctaaaaca ggtatgtcca gcaaggattc gagctgctct tccgatttga tcgtattatc 3357001 caaatgctca agcaggaagg ccagtccgat gcttcccgcc aatccggccg caaacgcgat 3357061 ggcaatgttt agtagcggct ttggcgatac aggggacggg tgttctgaaa cctcggcttt 3357121 tgacagaatg ctgacattgt caacattcat aatggatgtg attttgtctt gaaaaacaga 3357181 tgctatagta ttggcaatat gagccgctgt ttccgcgttt tcatccctga ctgatatgtt 3357241 gaccacttgg gagtcctgtt cgctggatac ggtaattttg tcattcagtt cttgggatgt 3357301 catcgacagg cccatttctt taatgacttc atctaagatg gcagggctct taatgatgac 3357361 attgtacgta ttgattaact gaagattggt ttggacatcg ttaaattgga cttcttttcg 3357421 ttcatttttc gattggttga ccagaatctg agttgaattt tcatagatgg gtgtaagtgc 3357481 gaagaaacta atgagtccgc cggcagcagt ggcagccgcg gttacaatca taatcaaaag 3357541 tatgcgtttt gttaacgttg ataatatctc ttttaagctt gtagattctc ccatgatacc 3357601 tccaaatctc ttataacatc cttttccatc tacgattata caacgttgaa accgcatttc 3357661 tccagctttt cacgtgacat aattcgacat ttttttacaa tgcgttatgt tagtactttt 3357721 tatgtaagcg ctatatttac tgtgttgaca gtgctgtctc attttctctt attcgggcag 3357781 tcacgttctc tcgcataaaa aaatcccgct aaaggcgtgc gggattttta tgttgcatat 3357841 ccatttttaa tatgagaaat caaattttca agcatttcct tcgtcgtcat ctcagatgac 3357901 tgctcaccaa tttcatgtgc atgcatcaaa attttcagaa attcttcttg attcaatttc 3357961 ttttcactca tctttttttt cctttcagct tccattaagt tgaaaacacg attattatat 3358021 gatgctggtt atcaatttgc aatctctaat acatcattcg acacatccta ttttttatgt 3358081 ccttttttag gaaaaacttt ttaaggccga tgtgttgcga tataatagag aaattggatc 3358141 tttttattac gtgactcggt taggagcgat aatcatgctt cagaatatga tttccaaaga 3358201 cgatgtgctg gcatctgctg aacagttaaa agaacttctt ccttacaatg aggaaaatgt 3358261 tcagctgatc aaaaaagccc ttattttata tcggcaggat tcagtctatc gtttacaagc 3358321 agtgagtccg acggaagtta cggcttacgt gcaggatgtt gtgcctgtgc gggtcacatt 3358381 gaacttgttt gtcatagtca aaagcggctg ttcatgtccg tccggaagaa tctgccgcca 3358441 tatgctggct gtgtttttat atgtatatgc aatgttcgag cgagtgggta cttttacaga 3358501 gtattggctg gagagggaaa agcttgagga aagcaaagag ctcgtccgcc gccagtttca 3358561 ggaaaaggtg ctgcctaatg aagaatcact ttcaagctgg cttgcttttt ttgattcaga 3358621 gttttctctc tggcaggcac gtacgccaga aggcagccaa aacatgcagg gcctctatta 3358681 cggctacctg tccgcattaa aaaaacatgc gccgaacaag ccggagctga aaagcctgta 3358741 tcagattcat tccgcgattg cggtttggct tcgcatgttc acattgattg aagcgggcaa 3358801 gctaaacccc gaacaagatt tttattccct caatccgtac gttgaacagc tgatggatac 3358861 aatctacagc tctattgata aattaaaaac gtacgcgctg tcttttgcgc ttgatccgtt 3358921 tttggataaa acaccggatg ttatccggca tttgctgttg aaagaagaaa ttttccaata 3358981 tgaacgcatc cgcgtcttcg gtgaaatttg gagtgcgctg ctgtcgcggc caaaatgggt 3359041 ggcacgcgaa caggagatat tgaaaaaaga agcaggacgg cgtttttctc ccgaattgca 3359101 attcgggcgc ctgcatttgg aattcctgca aaaaaatgat gacgttattt ttgaggaagc 3359161 ggatcaattc ccgccggaag cgctccctta tacattccaa tggctgagtg aaatgactgc 3359221 caagaaggac tggaaacggc ttaaaacatg gtaccagcaa attgaaccaa ttgcgatggg 3359281 ttatacgaag ctggataagc cgtttaaaga gattcgcgat gtgatcggcg agctgttcct 3359341 tctgttgaat gcctatgtgc agcaaaccaa tgatcaagcg ctgtttgagc gctttgccgc 3359401 gggctgtctg ccgtatacgt tcacagaata cagccatcat ttatatgaaa aaaaacgcta 3359461 tgccgagtgg attgaaattc atagccttgt cggcttttcc atcaatgaaa tggataaaat 3359521 gatgctcaag gaaattgcag cgagcgaccc tgaggcgctt ataccggctt accatagaga 3359581 agtggctttt ttcattgatc agaagaaccg tagctcgtac aaggaagccg cccggtattt 3359641 gaaaaaattg cgcaccctgt acaaaaaagc gaaaaagcag aaggtgtggg agcggtatat 3359701 tcagctgctg agctcgcatt acaagcgcct gcgtgcgctt caagaagaac tgcagaaagg 3359761 aaagttgatt gatggcgagt cttaaagaaa ttctcatcca cgtcgaacaa atggaagatg 3359821 ggtcatttac gctctcagcc tttgatgaga atgagcagcc tcttccctac agccatatga 3359881 aaaagcattt gttccaatgg catgaatcct cattttacgg aacctttcta gaggatgtca 3359941 gcttcatcgg gacgactgct gtccttctat ctccatggat gactgtagag cttctcggca 3360001 aaaactcgtt caactcattc agctccgtgc agcttacaga agaaacggag ccgctgatcg 3360061 aggcggcatc gaccatctat gaatttatcg cggacggcga ttttatgcct gactatgacg 3360121 catggacaaa cggtgttttt cgctggaagg accgcgataa tatactggaa ggctttactg 3360181 cggaatggtt ttccgctgcc gtacaggatt acatccagta cgacgatgac ctgcgggaga 3360241 aatgggaaca tatcaaggaa aaatcgcctg cggttacgac attccgtggc cattttcttg 3360301 atgaagagga ttttctggaa ggcattggct ggattgacga tcaatctcca tttactgtcg 3360361 gcttgcgctt aaatgaaccg gactttgacg gagacgaatg gaagatcgag atgtttttac 3360421 gcgataaaaa gagcggtgct gtagaattct ttgacggact gaagagcctc aaaaaatcgt 3360481 ggcaggcgta cagcgataaa atcgcgcgtg agcaggaccg ctttcacaga acggttccgt 3360541 ggctgtcgtt tgattccggg acaacgctga tctcggagga agaagcctgg atcttcctgt 3360601 cagaagcaag tgagacgctt gtcgatatgg gggtagaaat cctcctgccg tcctggtggc 3360661 agattgtcag agacagcaac atgatgctga aagcaaaggt gtcttcctcc ccgcgcggcg 3360721 agtcatttgt cggcatgaat gcactgcttg atttcaactg gcggtttgcg acaaatggaa 3360781 ttgaactgac tgaggctgaa tttaatgagc ttgtcgccag caacaggcgc cttgttaata 3360841 tccgcgggca atgggttaaa atcgatccgc agtttatcaa acagatgaaa cgcctgatgg 3360901 aaaaagcaga atcagaggga ctccacatgt ctgatattct ggcgcgggag ctaatggatc 3360961 agcaggatgg cggacttgag gattcggacc tgattgatac atctgctttt gccggcattc 3361021 agtttgatct gtctaaacag ctcaggtcac tgattcgaaa gctcactgcc gcggaaaacc 3361081 tgccggagca caaagtcagt ccttctttca aaggaacgct ccgcccttat cagaaatacg 3361141 gcatgaactg gctgctgttt ctgcgggaaa gcggttttgg cgcctgtctg gctgacgata 3361201 tggggcttgg gaaaacgatt caaatgatcg cctatttcct tcacgtgaag gaaagcggcc 3361261 gacaaaaaac gcctcatttg attattgcgc cgacatccgt acttggcaac tggcagcggg 3361321 agcttcaaac ctttgcccct gatctgtctg tcgcgctcca ttatgggccg cgccggccaa 3361381 agggtgatga tttcgccgcg cattatgaaa acgcagacgt ggtgctcact tcatacggtc 3361441 tgtcacatgc cgatactgaa gagctttctt ctgtgacatg gaacacgatc tgccttgatg 3361501 aagcgcaaaa tattaaaaac gcgcatacga agcaatcacg cgcaatcagg aagctgaagg 3361561 ggcttcacca tatcgcgctg agcggcacgc cgatggaaaa ccgactgact gagctgtggt 3361621 ctatttttga cttcatgaat aaaggctacc tcggcagttt gaccggcttc cataaacgct 3361681 atgtgctgcc gatcgaaaaa gaccgggacg aaaagagaat cggacagctt cagcaattaa 3361741 tccggccatt ccttctccgc cggacgaaac gggatgaaga ggtcgcgctt aatcttcctg 3361801 agaagctgga agaaaaagaa tttatccctc tgtcagccga gcaggcatcc ctttatgagc 3361861 agctcgtcaa agacactttt gaccatatga catccctgac cggcatgcag cgaaaagcgc 3361921 tgatcctcag catgcttgga cggctcaagc aaatatgcga tcatcccgcg ctttatttaa 3361981 aggaagagca aaccgagctg ctggccggca gatcagtcaa gctcgaaaaa ttgctggaac 3362041 tgatgacagc gatccgcgcc caaaacgaaa gctgcctgat tttcacgcaa tacattcaga 3362101 tggggaacat gatgaagcgg ctgcttgaaa aaacgttcgg ggaacctgtg caatttttaa 3362161 atgggagtct ctccaagcaa gagcgggata cactcgttga gaaatttcaa aggaaagaat 3362221 atccgacact gattctttca ctcaaagctg gaggcaccgg acttaatttg accgccgcca 3362281 atcacgtcat ccattatgac agatggtgga acccggcggt tgaaaatcaa gcgactgacc 3362341 gtgcataccg cataggccag gagcgctttg tccacgttca taaaatgatt acgacaggaa 3362401 caatcgaaga aaaaattgat gtcatgcttg aatccaagca aaccctgaac gatcaaatta 3362461 tccaaagtga aaactggatt accgagcttt ccacacagga gctcgaagaa ttgtttacat 3362521 taagcgctac agcgcaataa tcatgactaa aaaagctggc tctaaaagag ccagcttttt 3362581 tccgttcata gccgtcacgc cgaatttcca aaaaatccgt tacgccggtt atcaacaggg 3362641 tgcgcttttg tggcagcaca tatacttaca acaaatgttt catcatatgt gcgacaccgt 3362701 gttcgtcatt ggttaaggtg acagcatcgg ctatcgattt gatgtcttcc cgggcattgc 3362761 ccatcgctac accttttccc gcagcctcca gcatcgattt gtcatttaaa ctgtcaccta 3362821 cagcagcagt ttcctcgagc ggaatattca gctgttttgc aagcctcttc agcgcctgcc 3362881 ccttggaagc tttgcgggaa gaaagctcaa agttgtgctc agccgaactg acaagcgtca 3362941 aatcttcggc atgctcatat cttttccagc ctgcctcaag cttttctttg aagaaagaaa 3363001 agccgagaat attgtaaaaa tcgattggct catcggcttc aaacagctct tgaaaggagt 3363061 taatgtaagc aaagcccgat tggctgtatt gcacctcggc cgcctgctta aggacagaaa 3363121 gatccgcttc cggatttgcg cttctgaatc tgtcgagctc aacatcaaga agttctctgc 3363181 cgttttgcgg cgtataaatc gctgaacctg tgaatacctc ataataatag ttttccgact 3363241 caagccatga gagaatgtca tacgcccgtt tcttatcaat cgtttcgtga tgataaagcc 3363301 tgccctcggg atcgtgaatg acggcgccgt ttgcactgat gacccatgtt ttgatcccca 3363361 gcggttcaaa gattgacatg acgtcaaaat gagcgcgccc agttgacacc accacttcaa 3363421 tgccgtcccg ctgcgcctgc cgcagtgcgt tttcattttc caagcttacc tgatgcttgc 3363481 tgttgagtaa ggttccatct aagtcaatcg caattaattt cacgtttgtc agtcctttcc 3363541 ttcatcctgc tctgtcacga gaagctcaac gccgtttcgg tcaagcaagt cacaaaatgc 3363601 ctgattcggc agcctgtctg taatcaagag gtcgatttca ttcagctccg catactgata 3363661 aaaactggtg ctgcccagct tagaatggtc tgcaagcgca attacctgct ttgcctgctg 3363721 tatcattttc cgcttcacca tgccatcctc ttcatgcgca attgtaatgc catgttcgga 3363781 aatgccgacc acaccaatca gcgctttatc aacatggtag cttgagagct tttcaatcac 3363841 agaggacccg tacagaaagc ggtgctcctt ttccagcttg cctcccagca gataaatttc 3363901 aattccctct ttatcggaca gcacatccgc aagattaatc gaattggtga ttacggtaca 3363961 atcaaccgca ttcaaatgct ttgcacatgc ctgaacagtt gtagaggcgt ctaaaatcac 3364021 ccggtctcca tcatgaataa gcgatgctgc aagcctgccg atcttatttt tttcctcaga 3364081 cactgttttc aggcggccgg aatagctttg aattttctga tgcacagtcg gtaaaatggc 3364141 gccgcctctt gtgcggatga tggcattctg ttcctcaagt ttcacaagat ctcgtcgcgc 3364201 tgtatccctt gacacttgca ggagcgtaca gatctgctcc gttgtaattc ggttatgctg 3364261 ttttaaaaaa tccaaaatcg ctactaatct ttcttcttgg tacacgccct cattcctttt 3364321 ctcagcaatc atttataagt aattataagt ttttatttga ttttattcaa cattaataag 3364381 tgattttaag taaaaatgcg tcgagagaac caatttttcc taagtaggca aaaagaaaga 3364441 accagtctgg tcgactggtc aattttgagg ggatgatgcg aagatccgga taatagtgaa 3364501 tggatagata acgggaggag caggggtgtc aatcagcagc tttttcccgg ggtttagggt 3364561 ccataaaacg aacagtgtca gccaacactt ctgttacata cacgttaacg ccttcctcgt 3364621 tttcatagct tcttgtctga atccgtccgc ttacgccgac gagagaacct ttttggcaat 3364681 acaacgccgt gttttcagct gtttttctcc aaagtgtgca attgacgtaa tcagcttcga 3364741 tttcacctga agcattcttg aagctgcggt tcaccgcgag cgtaacatgt gcaactgccg 3364801 caccggcgga agtgtagcga agatcaggat cttttgtaag acgtccgaca agcatgacct 3364861 gattgaacat gcgattcctc ctctccttgc ggttgtatgt attgtaaatg atgcaacaag 3364921 aaaagaaaaa cgcttaaaaa tggctttcag cctctgtttt tatctttcgt tttcattttt 3364981 ccttcagcta aaaacatctt ttgctttttt cctttgaaga aatatgtact ttttaaaaaa 3365041 cggaaaaaga tttgctttgt cagccagttt tgcgtattca tgcgcacata ggaagagcca 3365101 tcccacgcaa accactgaaa gctcaatttt ttttccggca ttgacagctt gattttatac 3365161 tgctccatgc catcttgtgt ttcgtataaa aaacttattc ttcctttttt gttcagatga 3365221 acctcaaaca cttctttacg gcttaacata tatgttactt ccttttgaat caaatgactt 3365281 tcagaaggaa cgccgtcaat ataaatttct tttaaacgaa attgattcat accacatctc 3365341 tccgtaatcc atagtcagtt acagtataat gaaaaaatag aaattattaa atgtttcgct 3365401 catacaaaat tctttagccc caacattgca ggattttttc ctcgaaaacg tttatgttat 3365461 aatggaaggc aagaaaactt tggaagtaat cggggtgaga agaaatgaaa acctttaaac 3365521 tggttgacct gaatgtggaa cgagtggaca aggaagaaca atcaattgaa cagtttcccc 3365581 ttattgacgg actgattata aataaagaag acggtgaaaa tcactggctg attgaggcgc 3365641 ttgtacagaa agaacatctg tctttttttg aacagcttca aaacagccaa tctgaagcca 3365701 aagtatttgt aacgatcacg aaaaaaagca atcgccccgc ccagctgaca gcagcagtga 3365761 aaaatatcgt caagctggaa gaaagcattc aggttttact ctacggacaa atggtcacaa 3365821 gaaaacagca gggcactgaa accattctcg agtcccttgt aaaagagggc tatacaggaa 3365881 caaaactcat tgaggcattt aagcaaaaat tataaatatg agggggcatg ttccccaaaa 3365941 cagactcaga accgaagagc atcacaatag acatttagaa tagatatgtt ctgcatgaaa 3366001 aaagctgccg ttttgaacgg cagcttttct cttcgtgctt tcactcttgc atatttaatt 3366061 tgtatggcca aaagaatcaa ccaattcccc tttcacaacg aggcgccctt cggttttgac 3366121 cgccttgtca catgtgatta acgtaatctc ctttttgttt gtctcctcaa ctacatctgc 3366181 atccatttcc gatatgatgt ctttcgatgt tacagaatag atataatcct ttttaaaatc 3366241 cgtgatgaca atttgggcac ctgtttttat gttttccaga ggtccgaaca gaagattctt 3366301 ttgcttcaaa tgatggcccg ccaacggata atttccctca cccatttttt gatcccggcg 3366361 cattgttgcc gcccctatca aaagattttc attggttgtg ccttttacga tcggaagctc 3366421 cagatcgaca cttttaattg ttatccgccg ccttgattgt gaagtaaaaa taagtatatt 3366481 tcacgtgctt tcgacgttct ccacttgact ggaatgcttt aatggcgatc ccggcatctg 3366541 tagcttcagg ctttccttca gaggaatcag aaatctcaaa ctctattttc tcagtgttca 3366601 gcacataacc ggctggcgct ttcgtttcaa caaaagcgta ttgtcccggt gcaaggcctg 3366661 aagctgtgac ttgatgatgc cggatatgac tggtttcgaa gtctgtatga aaattcgcga 3366721 acgattcagc atggttgatc ttccggttct gatcattaca gctgccatta tcggccatga 3366781 caaatacaag gcttttcatg ccggagcgaa tgacattttg caaaaaccct atcattactc 3366841 tgaatttatg gcgcgtattc aaaacctgat aatgatgaaa catacagcaa atcaagccac 3366901 aagaatggaa atggcgtttc tccagtcgca aatcaagcct cattttcttt ataatgtatt 3366961 aaacacgatt atttctctca ctcatttgga tattgaaaag gcccgggagg taacagagga 3367021 atttaccaac tatttaagaa tgagttttga ctttcaaaat acatcagcca tcagttcctt 3367081 cagacatgag ctttcgatta tcaattccta tctttctata gaaaagacgc gattcagtaa 3367141 tcggcttgag gttcttttcg atatagatga agacattgac tttatccttc cgcctttaat 3367201 gattcagccc ttggtggaaa atgccgttct tcacggtgtc agcaagaaaa gaggcggagg 3367261 atggatcaaa ctgacagcta aaaaacaaag caaaaatgag tatcacatca aagtagagga 3367321 taacggtccc gggataactc cggaaaaaca aatagatctc ttatcaacgg attttgatcg 3367381 cagcgtcgga ttgaaaaata tcaatcagcg gctgaaacat ttttgcggaa gcgagttgat 3367441 gatcagcagc actccggatg caggcacctc tgtctcaatg ctcattcatc tcgctgaaac 3367501 aacaggaagc cctaaagaac tgaaggacac agaacgaacc taaacgaaaa ttgagataaa 3367561 aaaagacgcc gtttctaacg gcatcttttt tattccggcg actttgcttg ctgcttcagc 3367621 aggtctctga tttctttcag cagctcctcc tgcgcatcca ccgcttcctc cgcagcctct 3367681 tcttctgctt cttttttgcg ccttaaccca ttcaaagtcc gaatgacgat aaaaatggag 3367741 aacgatataa ttaagaagtt cacaatcgtc tgtataaagc tgccatattt cactacagca 3367801 tcgccaaacg taaacgacag gcctgaaaag tcaagccctc ccagcagcaa accgaccaaa 3367861 ggcataatga tatcatttac tagagatgtg acgatctttc cgaaagcgcc gcctatcaca 3367921 acaccaatcg caaggtctac gatattcccc cgcatggcaa aggctttaaa ttcattccac 3367981 atacaatcac ctgcttttct atatttgtaa agaaaaaaag acaaatgtgc cgctggccat 3368041 ctgccttttt tcaattattc tccgagggca aaagtcagtt ctacttcgca aacgacttcg 3368101 ccatcaactg tggcaacgcc ttttccgcgc ccgattgtgc cgcgggcacg aatgatttca 3368161 acctcaaggt gaagctggtc accaggcttg acttgttttt taaagcggca gttatcaatg 3368221 cctgcaaaaa aagccagtct gccgcggttt tcttctttaa tcaacatcgc aacagctccg 3368281 acttgagcga gtgcttctac gattaatacg ccgggcataa ccgggtactg aggaaaatgt 3368341 ccgttaaaga actcttcatt agcggttaca tttttatagc cttttgcccg tttgccctct 3368401 tcaacttccg taatccgatc cacaagcaaa aacggataac ggtgaggaat aatttcttta 3368461 atttgctgag tatcaagcat tgtcttgaca tctccttcat ctgcattagt atgtatagca 3368521 atcatcaaag atccaatctg tacatttgaa aagtatatta tgaattaatc tctttttcaa 3368581 ccgcgctaaa atgtaaccaa ctgtcaatga gagccgtcaa aagttatgat atgataatta 3368641 tagattttac caatagcaaa gaggtaggaa aatgatttcg aagtttattg aaaaaagaat 3368701 gctaaacatg ttagacgagt ggtattccgc aatgagcaaa cgcaaaatga atcacgtttg 3368761 cacactgaaa gagaaaattg atcagcacct tccaaagatc aaaaagaaca caaaactttg 3368821 gatgcgttat caattgtttc aggcccgcca tcagctgctt tttgaaaacc agaacggact 3368881 cgattcattg ttcgatggcc tatatggcct ggaagacaaa atggatgatg aattgaaata 3368941 ttatctgtat tttttctctg ggttatatga gatggtaaaa acagctccga aacatgcagt 3369001 acatcatttt aaaaaagctg aacagtacct ggccgccatt cacaatacgt ttgaagccgc 3369061 tgatttatat tatcaaaccg ccggcgccta ttacttgatg aaatcaccgc cgctttccgt 3369121 ccaatacgtc aaaaaagcat tacacatcta tttgcaccaa ttcggctata tcaaaaaggt 3369181 aatcacctgt aaacttttgc tcgccgtgaa ttatattgat caagaacgct atgaaaaagc 3369241 tgaacagctt ttcaaagaaa tcattaagaa aacccagcaa ctacatgacg aaaacctgct 3369301 atgccacgct tattataacc ttggcttttt aaaagcgacc gagaaaaaag accaggaagc 3369361 gcttctttac tttagaaaag tattaaagaa tcaagaattt gaaatgaatt caccagtctc 3369421 atatcttcat tgtgtgtacg agtctgtcag agcgcttttt aaaacaggga acatcacaga 3369481 agctaaagcc gtccttcaaa aaggaaaaga attatctgaa aaggtagaca ttcaaaccat 3369541 ttatttaaaa ttaaaaacgc ttgaagccct ctacacatca gccgaagacc cttatgagca 3369601 gctgctcgaa tatgtgcttg aattagaaaa aatcgaggcg tgggtggatt tagaagtgct 3369661 gttagaagat attacggaat actacaaaaa aaaggacgat ttcgaaaaag ccgctttttt 3369721 tatcatgcgc ggctgattga aaaacgccca ttttcttatt atctgactga attgattaaa 3369781 ccgagcattt gatctcccat tgtgatcgtt ctgctgttca gctgatatga acgctgggac 3369841 gtgatcaaat ctgtcatttg ttctgaaata tcgacattgg acatctcaag tgagccctgc 3369901 tgcatgccga tgttttgtct attagcgccg ttcagctctt caaaagctgc cgcattatca 3369961 atagagaaaa ggttattccc ttcggatttc agctcttgag ggttattcac ttggacaacg 3370021 ccaagattaa accgctgaac cgcgtttccg tcagatgcgg ttaaggtgcc gttcttatta 3370081 atggtgatat tcttcattga gctgtcgatg ttcactgtat tgccgttctc atcaagtacg 3370141 ggatacccat ttccagtgac gagctgcagc tggttggcat tcgcagcgga cggcgttaca 3370201 tacagcgccc cgtccctcgt atactggcgg tttccattta catttacctg aagatactgg 3370261 tatggagacg taaatgcgat atccagatcg cgatcggtct tctgaatgct tccttgatca 3370321 gagactaggc gtgaactcat catcgctccg acgccaaggc gcaagccggg cggcgttttt 3370381 cgggcttttg ccacttcctc gtttttttca tcaacctgat cgaattgctg tctgacaagc 3370441 tcagaaaaat tcgtatcttt tgccttatag ccggttgtgt tgctgtttga aaggttgctg 3370501 ctgattgtgt caatctgctg ctgcagctgg tttaaggttg ttgatgccgt tagcattgac 3370561 ctgagcatag ttgatgtccc ccgttttttt cttccgtttt cttaaatttt tccaatttca 3370621 tttgctgctt tatccatact tttatcgtaa gcctgaataa ccttctgatt cgcctcaaac 3370681 gatctgtacg cttcagtcat ttctgtatag gcgcttgtca catccacgtt tgaaagctct 3370741 gagacgcctt gttttaatga ataggctacc tgattatttc cggctgcgct tggcagatca 3370801 ttaccgtccg ccgtgctgta caaatcattt ccgtcccgtt tgagattgcg gacatcttcc 3370861 gccattctga catcaatctg gccggctgtg cgtccgttcg ttgtcacagt accgttttca 3370921 gacacagtga aattctcatt atcaacagtg attggctggc gatccgtcga taaaataggg 3370981 cgtccgttga tcgtcagctg attgttctca tttagtgaaa atgtgctgct ttttgaataa 3371041 cggattccat ccgctgtttg aaccggataa aaaagagcag ctttttcatt ggtttccgca 3371101 ctcatcggaa cttgattttc gatcaatgca atgtctgtag gctggtctgt ggacttcagg 3371161 cttccctgtg taaagagagg cttgagctcc tgcatatata ctccggtatt cacggaaccg 3371221 atttccgtcc ttgatgtccc ggccggagat tttgattcta ttctgctgag cagcatctca 3371281 gggaacgcgc gcatagagcc ttgatcagct ttatatcctg atgtatttgc gttagcaata 3371341 ttatttgaaa gcatttccgt tcttcgctgc tgggcaatca ttgcggatgt tgctgtatat 3371401 aatcctttta acaaatttcc cacctctaaa aatggcattt tttccagttg tcatatagga 3371461 acgttcgttc tataataaaa actcagtatt ttatcctatt atcgtcattt aacatctttt 3371521 cgtgaaggct ttttcataaa aaaacctcat tctttttcag aatgaggttt gtgaaatcag 3371581 cttagtttgc gtttaggaag cttgtccata ttatcaagca tgacacctgt gccgatggct 3371641 acgcaatcca taggattttc agcaacgagg accggtacct tcagctcttc agcaagcagc 3371701 tggtcaaggc cgtttaagag cgcgcctccg ccggtaataa taacgccgcg gtcaataata 3371761 tcagcagaaa gttcaggcgg tgttctttcg agcacttgtt ttgcagcctg aacaataaca 3371821 gcgacagatt cacgaagggc ttcttcaact tctttactgt ttactgtaat tgttcttgga 3371881 agaccggaaa ccatgtcccg tccgcgaatg gaaatttcct cgtgacgtgc gtctgggaaa 3371941 acagttgcga ctttaatctt aatatcctcc gcagtacgtt cgccgatcag cagcttgtac 3372001 tcgcgtttga tataatttaa gatttccatg tcaaacttgt ccccagccat tttaatagaa 3372061 gaggaggtga caatatcgcc cattgaaata accgcgatat ccgtcgtccc gcctccgatg 3372121 tctacaacca tgttaccgct tggctggaat atttccatac ccgcgccgat agcggcaact 3372181 ttaggttctt cttcaaggta cacatgtttc ccgccgcttt tttctgcagc ttctttaatt 3372241 gctttttgct caacggatgt aatattcgtc gggcagcaaa tgagcatgcg cggctttgag 3372301 aacaggcctt ttacattcag cttgttaata aaatgtttca gcattgcttc tgttacttca 3372361 aagtcagcaa taactccgtc tttcagcggg cgaatcgcaa caatattccc aggtgtacgt 3372421 ccaaccattc gtcttgcctc ttcgccaacc gccagcactt tgccgctgtt tttatcaagt 3372481 gcaacaacgg aaggttcatt cagaacaatt cctttacctt taacatggat cagtacattt 3372541 gcagtaccga ggtcaatacc aatatccctt gcaaacatct atttatatcc tccttgaaaa 3372601 tctgtttcac agtaaatatc cacattgtgc cctaattata tatattatca taaaatatag 3372661 aaaaaaagtt ggaagcacaa taagttcttt acaaattttt gcggatgttt tatgaacgat 3372721 ttcaagaagg caatgccagg tgattacgat tgctgaacag gctctccttc gagaatttca 3372781 tcttttttat atttgagctt tgtcgcttct cctcctctta aatgcctgat ggatttatga 3372841 taatcgagta tttctttcac ttcgtttgcc aagtcggggt taatttcagg cagacgctct 3372901 gttaaatcct tgtgtactgt acttttggaa acaccaaatt ccttcgcaat gacacgaacg 3372961 gttttctttg tctccacgat gtacttccct atcttgattg ttcgctcttt gatgtaatcg 3373021 tgcacaccac tcgacctccc taaaatggat gtgagaagtg tgaaatgaga tccgtattct 3373081 gtaaagagtc gttcattatg ccgcttcttc gttgtatggt tttaaaagta agtttgtgaa 3373141 atatgcccac gatccctcac ctcaaacact ctctttgtta ggtttgtaac agtgtattag 3373201 cattcttttg ggaatatgct aaaaactcaa taaggacaag gggtgaaacg aactttttca 3373261 gattcagcaa actatttcgc gtcactaaat tttcatcttt acaactattg atcgctcctg 3373321 taaaatgaaa taagcaatta gttacttagg taagtttttt agaaggagac cgacatgtcc 3373381 tacgtcaaca gacacctcat tcatcaaatc aaccaaagcg cccgcctgat tgccaagaaa 3373441 gccaatgaac agctagagcc attcggcctt tattcatctc aatggtcagt tttatattgt 3373501 ttgcgtacga tcggaccaat gactcaaaaa gagatttggt cctatttaaa tgtggaagcg 3373561 ccgactgtga ctcggacgat caaacgcctg gaggagaacg gctgggttca gagacggcaa 3373621 ggtgaagaca aacgggaaaa acttgttgtc ctcacaaaag aagccgagaa aaaatacgaa 3373681 gaaatcaatg tgaaaatgtt gaaattcgag gaagagctgc ttgcagattt ccgggatgaa 3373741 gataaagaag ctttttctca tttattccgc atgtttttac aacaatgaaa ataaggaagt 3373801 gacatacatt tgaaaaaagc ggatgcgata tggaccaagg attttattat ggtcctgctt 3373861 gtcaatttat ttgtgtttgt gttcttttat acatttttaa ctgtattgcc gatctataca 3373921 ctgcaagagc ttggcggcac agaatcacaa ggcgggcttt taatcagcct gttccttctg 3373981 tctgcgatca ttacacggcc tttctccgga gccatcgttg agcgtttcgg gaagaaaaga 3374041 atggcgattg tatcaatggc gctcttcgcc ctatcatctt ttctgtatat gccgattcat 3374101 aacttttccc tgctgctcgg attgcggttc ttccaaggga tttggttcag cattttaacg 3374161 actgttacag gtgcaattgc cgctgatatt attccagcca aacggcgcgg tgaagggctt 3374221 ggatactttg ccatgtctat gaacctcgct atggcgatcg ggcctttcct tggcctgaat 3374281 ttgatgagag tggtaagctt tcctgtattc tttacagcct ttgcgctgtt tatggttgcg 3374341 ggcttacttg tttcgttctt gataaaagtg ccgcaaagta aggacagcgg cacgactgta 3374401 ttccgttttg cgttctcgga tatgtttgaa aagggcgcac tcaaaattgc gacggtcggt 3374461 ttgtttattt ctttctgtta ttcaacagtc acatcatatc tgtctgtatt cgccaaatca 3374521 gttgaccttt cggatatcag cggatatttc tttgtttgtt ttgcggtgac aatgatgatt 3374581 gcacgcccgt tcacagggaa attgttcgac aaagtcggac cgggcattgt catttatcca 3374641 tcaatcctga ttttctctgt cggactctgc atgctgtcct tcacacatag cggcttaatg 3374701 cttctgcttt caggggcggt tatcggtctt ggctacggat caatcgttcc ttgcatgcaa 3374761 acattggcga ttcagaaatc tccggctcac cgctccggtt ttgcgacggc aacgttcttt 3374821 accttctttg acagcggaat tgctgtagga tcgtatgtat tcggattgtt tgtagcatct 3374881 gccggcttct ctgccattta tttaacagcg gggctgttcg ttttaattgc tctgcttctc 3374941 tacacgtgga gccagaaaaa acctgcagag gctgaaggaa aagtgtctat tgcagaataa 3375001 cttgtcagac tgccgggaaa tcccggcagt cttttttcca ttaaaacacg gcgccctctc 3375061 ggttgaacga gagaacgccg cttatagcaa ttattcaatg acaggccgcg caggtgaatc 3375121 aggatctaac gaaaaatcat aggacgcttc atcacgaaac atcggatcgg catatatgga 3375181 ttgttgatcg ttttttgttg cttttcgata cgaagaaaat gaatcatatt ctttcttttt 3375241 ccacatccat atgccgtctt gatccgcttc cttgtggtac acgttatgat tgaccgtatt 3375301 accttcgttt tctgtaaagt cgtttccgat aaataatctg gaatcaccgg ccgtcaatat 3375361 attcttttca attgtgttgt ttttcgtatc gtactgcagc agcagctgtc cgccgtacag 3375421 tccctttgtg tcattccggt acataatatt gcgggcaatc agagaattgc tggtgccgcc 3375481 ccgctttttg tcatatcctc cgattgaaat accggtgtac gcattgttgt acactttgtt 3375541 gtctgtgatc tgaatggcat ttgcatactt tcctttgtgt tcagacgttg cttcaatccc 3375601 aatatcgtta tcgtaaactg tgttgttctt aatttcgata tcgtgtcctc catcgacata 3375661 aatcccgccc gctgagtatt catctccata agcaggattg ccgtaagtcg agttttgata 3375721 aactgtattg ttttctacga ctccgtttcg cacgtaatcg tttttatccg cggttccctc 3375781 ataaccaatt agatcaatcc cgatgttatt attgttgcgg accacattgc ctgcaactgt 3375841 gaagccgtcg atattaccgt tcagcacaac tgcttcactc gctccaagcg tcagtttctc 3375901 aactgtattg tcctcgattc ggatgtcttt catgctgcca gtcccataaa ctgcgattcc 3375961 gtgagcattt ccttcatccg ctgttgtctt aatcccccgg atgtgattat ccttaatggc 3376021 gatatgactg ctggaccctg atacataaat ccctatagca gttgcttcct cagatgaaac 3376081 agaaagatct tgaattgtta aaccgctgat ggcaatgtca tgtttatcgt gaatacgaat 3376141 aagcggtgtt tcatattcag cgttcgcaac ggattcaccg ctaatcacga cgttttcatt 3376201 ttcatagttt cggaatgtga taggctttcc gtccgtaccg ctgtgcttta catcaagggt 3376261 ctcatgatac gtgccctccc gaatcatgac agttgtgccg gcagcagcct tctcagatgc 3376321 gtgtgccaat gtacgaaacg gcttttcttt tgttccttca ttttgatcac tgccatttgg 3376381 cgaaacatac agataatccc cagatccttc ctcattcgct tttgtcttat cataaacgaa 3376441 agcgaggatg acagacgtta aaacacccgc caaaagaata aaataccatt ttctcatttt 3376501 cgattcccat ttcgttttag aatagatttc taaaaccatt ataaatgttc tatttatgga 3376561 aaaccatttc aaaaatatga aaatataccg tctaaataga tcttattcag cctggcggac 3376621 ctgcgcatgt tcaactgttt caattgccaa tgatgcaggc gggtgaacac gcatcagaac 3376681 aatgtagaaa agaaaggaaa tcagcacacc tacaaaccaa gaaatatcgt ataagctctt 3376741 caatacagga acatacatgc caatcagcga aatcagcgct cctaacattg tggctgcaaa 3376801 cgcacggtaa ttgtagccct tccaatacac ataccgtcct gtttcggaat acaggtcatc 3376861 taccgagagc tcacgtttgc gaatgataaa atagtcggcc atcatcacgc ctgccaccgg 3376921 tccaagcatg ccgcctatta agccaagaaa cgcatacacg cttgtcgcgc tctccatcag 3376981 cttccacgga accgtaaata aagcgagcaa cgctgtgata aagctgccac gtttgaaatt 3377041 gatatatttc ggcagggcat tcgctatatc ataagcgggt gatacgatat tcgccgcgac 3377101 atttacagag atcgtggcga tgcagagtgt gatcacggac aagacgatga cataagggtt 3377161 atcaaaccgc gccaaaatat cgacaacatc ccaaatcggc tctccgaacg cgacctgcga 3377221 gccggaggtc accgtaatac ttgcgaatgc gaacagcgca aacgttcccg gcaaaccgta 3377281 aaattgtcct ttgatttgct ctttttgtgt ttcagcaaac cgtgtaaaat caggtatatt 3377341 taagatcaat gtcgcccaga tgccgatgat gccagtaact ccggcagcaa acggccagaa 3377401 tgtttctgaa aacgtatgaa actttcctgg ttgagagtat atcgggccca atcctccagc 3377461 aatatcaacg gcccaccata ccatgccgcc aaataccaga tacactaaag gccctgccca 3377521 cacctcaaaa cgtttaatcg actccatgcc gtgatgcaat acgagtaaat gaatggccca 3377581 aaagaataca aaggaaagca aaccggacaa gtgaatgccg agaatgttcc actcgccgcc 3377641 aatttctccc caacctggcc acatattcaa aagcaaaatg ttcagtgccg tgctacccgc 3377701 aaaggtctgg atgccaagcc acatgatagc tgtaaacgcc cttagaagcg cggggatatt 3377761 cgcgccgtat atcccgtaag aagcccgaat gatcactgga aacggcagcc cgtattttgt 3377821 ccccgcatgg ccgtttaagg caagagcgcc aaataggata agtgatgccg taataatgat 3377881 cgccagcacc tgccaaggcg aaaggccgat cgcaattaat cctcccacgg tcgcgtaggt 3377941 cggtatgtta tgtatacatc ccatccaaat ggaggcaaag ttcattgctt tccacgtccg 3378001 tttttcctgt cccaaaggca ccagatcttc attgctcagc ctgttggatt gctgctgact 3378061 ctcttttaat ttcatagccg gctccccttt ccatattgtc tatatgtcgt cacacgttat 3378121 gttttttgac attagatgtc acttaatata actgaagagt cagacaataa cactggctat 3378181 gatatacaat tttcccgttt gtatttgaac agcttaaaca agaaaaagag acagacctca 3378241 gagcccgtct ctttcttaag atgcagtttt cattaatgca gcaaatctca cagccattaa 3378301 caggcttgct ccgcccgcta taatcataat gattcccatc atatcaaaat gggctgccgt 3378361 gatttcttta ccaaaaagaa tgccaaggat caccgaagac aaaatcgatc ctaggtaacg 3378421 gcaggtttga aacaggcctg aagtcgttcc taccatgttg gaaggactcg tttccagcat 3378481 cgctgcctga agcgcgacat tgcccagtcc gtagcctata cccaagagcg acagaatgag 3378541 gcctttaccg atggtctgga cattgataaa aaagatggtt aagagcacgg ctccagccgt 3378601 catcaaaagc gctcccgcaa agatcggctt gacgacacca gatcggtcga tccatttgcc 3378661 ggttagaggt gacacaacga tgctcattcc agacataaac agcataaaca ggccgctcgt 3378721 ttgaacagaa agatgcattt catcctgaaa gtaacttggc aaaccaaaaa ataaacaata 3378781 gaagaaaaca ttcaataaaa taaactgaac atacacggct gacaggtttc gctgtgtttt 3378841 aaacagacgg acatcaataa acggcttatc cgttttcagc tcgcgccaga caaacgcaca 3378901 gagcagaagc aagccaagca caccttcaac cgcatgcggc gacgtgctga acgacagcaa 3378961 aaaggataga aggaaaatga ttcccccggc aaataaaaca attccaagaa tatcgagctg 3379021 ccgaataatg gttttgattc ctgccccttt tttctgatct ttcgggaaca tatacaggcc 3379081 caataagaag ctgaggataa taaacggcaa attaacgata aagatcgccg gccagcctcc 3379141 ccatacaatc aaaaacccgc cggctgtcgg ccccagcgcc gtcatggcgg acgcaaaaat 3379201 agagagtaca gccaaggctg aagcttggcg ctcatgaata tgattccgaa tcaagccgac 3379261 acctgacgga taaatcgcac tgctccccac cgattgaaac agccgcatga ccaataatgt 3379321 cataaacgtc ggcgcaaacg gcgccccgat ggcagaaacc gcaacaagaa taagcccgaa 3379381 taaaaacaag cgtttccgcc caatcaaatc accgagcttt cccgttacgg gctgcgctac 3379441 ggcactcgcc aagtaaaacg aggaaatcag ccaggaaacc gttgtaaacg agaggtgaaa 3379501 ctcatgctgg atgctatgga gcgcaagaga gatcatagac gagttcagcg gattcagcat 3379561 tgttcccgaa gccacagctg ttaaaaaaac agctcggctt tttttcgata acatcatttc 3379621 acttgttcca gaaactcttc cgttgtccgc gatttaccga ttctcgggaa aataaagcgc 3379681 agtgtggctt catgctcttc atcgctaaat gtggacatgg catctgtaat aaaaatctgc 3379741 tgatagccaa gctgaaatgc ctcccgtgct gtgctttcca ccccgatatt cgttgcgatg 3379801 ccgcacaata caatcgtatc aatgccgcga cgtctcagct gcaagtctaa atctgtgcca 3379861 aaaaaagcac cccattgccg ttttgtcaca gtataatcgc catcctgcac accgatttcc 3379921 ggaacaaatt cggcccagtc cgccggcatt tcccctgaac ctccctgcgc aggctcatcc 3379981 gtttgcggct tcagggcgtc cgctccatca tgaaaggcta catttacaaa gctgatgaac 3380041 ccgttatgtt tccgaaattc atctacgagc tttttcgcgt tcgggacaac ctggccgctt 3380101 tgatcaatcg gcacaattcc cttttgtaaa tcaatgataa ccaatgctgt tttttgaaaa 3380161 tcaatgttga gtgtattcat catacgtctc ctcctgatac tgttagtgtt tctcacattg 3380221 catattttac tcttcacact gcctaagttc ttttatgatg cttgtgaaat tctcagaagg 3380281 agcgttttct catgattttt cttttatgta gtagtaacag gttgtgcata cgaacaaacc 3380341 ggcaagcact gtaatcataa agggcgtcat cgcttcatca cctgcctgct gtctatcggt 3380401 tcctgcctga aaatgcccat gaatttgcgg cggtccatcc aaagcaggat aagacacata 3380461 accattaata tcgtgctaag atcctgcacg ccaatatcaa aacaatagtt aatcaagacg 3380521 atgttcacaa taatgggcat aaaaataacc gcccctaatg cagccgttcg cggaatcagt 3380581 aataaaacag ctgccaggat ttcaccaaaa cctataaaca gttcatagac atgagaataa 3380641 ccgaaaaatg tccacgcgat cgtaaacccc ttcccggcag ccgcctcgat ttcaggcgtc 3380701 acctcgccaa actggccaat taccactttc gccagaccgt acacgaaaaa attaaaggct 3380761 aaaaacaatc ggaacgtcgc gggaatcgac ttgcgtaccg ctttcctcag cctgccgcct 3380821 ttattcatca tacatccccc tcagtgtatt atttgatgta gtacacttaa tacagtatag 3380881 agtattctaa ttaatgtcaa ttcccttttc agctcatatg aatagtttct tttatagata 3380941 caaagtctta tatcgcaaaa aatgccattc tccttccttt ccatccctcg ataacatttc 3381001 tcaaaaacca tgtcaggaaa tcttacatga aaatgtttta tcattctttt ttctctataa 3381061 tgaagaaata taataattgc tttttattct gaaagatacg gaggaatgag acatgcaaat 3381121 gggcgataca gtttttatgt tcttttgcgc tttactcgtg tggctgatga ccccgggatt 3381181 agcgttattt tatggaggaa tggtaaagag caaaaatgtg ctgagcactg ccatgcacag 3381241 tttctcttcc attgccatcg tttccatcgt ttgggtgctg ttcggatata cacttgcctt 3381301 cgcaccaggc aattcaatca tcggcgggct ggagtgggca ggcctcaaag gggtcggatt 3381361 tgatccggga gattacagcg ataccatccc ccactcgtta tttatgatgt tccaaatgac 3381421 gttcgccgtt ctgactacag cgattatttc cggggctttc gcagagcgga tgcgattcgg 3381481 cgcttttctt ttattctcgg ttttatgggc ctctttggtt tacacacccg tagcgcactg 3381541 ggtatggggc ggcggctgga tcggccagct tggagcgctc gatttcgctg gcggcaatgt 3381601 tgttcatatt tcctccgggg tggcaggact tgttcttgcc attgtgctcg gcaaacggaa 3381661 agacggtaca gcgtcttctc cgcataacct catttacacc ttcttaggag gagctttgat 3381721 ttggttcggc tggttcggct ttaacgtcgg cagcgcattg accttagatg gtgtggccat 3381781 gtacgcgttc atcaacacaa acaccgcggc tgcagccggg atcgccggct ggatcttagt 3381841 agaatggatc attaacaaaa aaccgacaat gctcggagcg gtatctgggg caatcgccgg 3381901 gcttgtcgcc attacgccgg ctgccggatt tgtcacaccg ttcgcttcca ttattatcgg 3381961 catcatcggc ggagctgttt gtttctgggg agtattctcg cttaaaaaga aattcggata 3382021 cgacgacgcg cttgacgcct ttggcctgca cgggatcggc ggcacatggg gcggaatcgc 3382081 aacaggatta ttcgcaacaa cctctgttaa ctcagcgggc gcagatgggt tattttacgg 3382141 tgatgcaagc ttaatctgga aacaaatcgt cgccatcgcc gccacttatg tttttgtatt 3382201 tattgtcact ttcgttatta ttaaaattgt aagcctcttc cttccccttc gcgcaactga 3382261 agaagaagag tcacttgggc ttgacttaac gatgcacggg gaaaaagcat atcaagattc 3382321 tatgtgagga gtgacgctat gagcggtcaa atgttcaagg tagaaattgt aacgcgtccg 3382381 gcaaattttg aaaagctgaa gcaggaactc ggaaaaatcg gagtgacctc tctgactttc 3382441 tccaatgtac acggctgcgg ccttcaaaaa gcacatacgg agctctatcg aggggtaaaa 3382501 atagaaagca atgtatacga gcgtttaaaa atagaaattg tggtcagcaa ggttcctgtt 3382561 gatcaagtga cagagaccgc taaaagggtg ctgaaaacgg gatcaccagg tgacggtaaa 3382621 atatttgtct atgaaatcag caatacgatc aacatccgca caggcgaaga aggacctgaa 3382681 gcactttaat atcggtacga gattcggaca ctccggatct ctttttttgt gcacagaatc 3382741 cccccagaaa ccgcgattcc tcttcgaatt ctcttcaagc gccgttattt cagacaatct 3382801 ctatttttat ttgaaacttt tcatgagtaa gattagtcta ctaaatataa aaatgtaaaa 3382861 ggtgattatt tgaactacga aatttttaaa gcaatccatg gactatctca tcacaattca 3382921 gttctcgatt ccattatggt cttcatcacg gaatatgcca ttgtcgccta tgcccttatc 3382981 ctattggcaa tctggctgtt tgggaacaca caaagcagaa aacatgtgct atacgcaggc 3383041 atcacaggaa ttgcaggcct tgtgatcaac tatttgatta cgcttgttta tttcgaaccg 3383101 cgcccgttcg ttgcgcatac agtgcataca ctgattccgc atgctgcgga tgcttcattt 3383161 ccaagtgacc atacgacagg tgcattagcg atttctattg cgatgctttt cagaaaccgc 3383221 aaaatcggct ggccgcttgt catttttggg cttttgacag gcttttcgag aatttgggtg 3383281 ggacatcact atccggtaga tgtattgggc agcctcgttg tcgccatcat tatcgggttc 3383341 cttttcttta gattttcaga tctgcttcgc ccgttcgtcg atttggtcgt gaggatctac 3383401 gaagccatta tcaataaact gacgaaaaaa ccaaccgatc aaaatttcta agaaagacaa 3383461 aagccggcgt ctgaaatcaa gacagccggc tttaatattt ctcatacatc tcttgttttc 3383521 ttcgcttcgc caacacatat aaaccataaa acaacccaat tccaacagca tcgatgagca 3383581 catcccggat acaaccattc ctgctgaaga agagctgaag aacttctgtg aaaaaagcaa 3383641 acgcaaatga gccggctgca gctgatctta tgctgccccg ctgtttccac agcaaatatg 3383701 tcagcacaaa gaaggaaaac gcgtgtccga ttttttgaat aaacgcttca ggtacagtaa 3383761 gctcagtaaa atccataact aaaaattgag acagatcagg gtgcggctga aaatgaaaag 3383821 ccaccgtttg cgatacgacc atgccgctga agctttccgt acagacagaa agcaggataa 3383881 aaaagatcca gcctgcgagc aataggcggt tcatgacata acctccttta taacgtacgt 3383941 gcctacatgt aactacatag acggtaaaac aaagcaaaaa gtaacagaaa aaaacgccca 3384001 tcacaaggat agacgttttc ttcattaaga ctgttcagtg tcttctgttg tgctgctttc 3384061 tttagaacca gatttgtcag ttgaatcatc ctttttctca ccggattttt cttctgttcc 3384121 tttttcagtt gatccgtcct ttttctcgga agattgctga atggattctt ctgtttcttg 3384181 ggtggcagct ttttcaatag aagaaactgg tttgtccata aagtttaacg gattcattgc 3384241 aaccccatct ttacggattt caaagtgcac gtggtttccg ctgtcttcac tgtaaaggtt 3384301 cttgccagat tttccgatca cttgattttg ttttactttg tcaccttgct ctacgcttac 3384361 ttcggaaaga gattgataca cagtcgataa accgtcggca tgttctactt ccacaacata 3384421 tcccagcact ggatcttttt cagctttaac aaccgtaccg ctcagagaag cagagacatc 3384481 gaaatctttt ccgtctttct cagctaagtc aattcctttg cttaggctgt acgtgttatt 3384541 ataggtaacg agtgctgctt ctttctcttc ttttgcggca tcggtttcat agaacttttt 3384601 cacaacagaa acgttttcag aatcaacaac cggcattgcg acattttcca ttgactttcc 3384661 tacttcaact gcatcgtcgt tgttgtcata tgcggagttt ccgccgttat cagccaactg 3384721 atcctttacc tcatcatttg atactgattg ataccaaagg acagctgtta aaatgacggc 3384781 cgcactgact aagtaaattg cagggaacac ccagcgttta cgaaaaaact gctgaagttt 3384841 tttgacttga gaagttttct tttcttcctc tctcattgtt tcatcacctc agcaacattc 3384901 tgaacacttt tctgaaaata tatacaacct atccaaaaaa acttttttag atgtagtttg 3384961 cacagactga acgaaaatat gtattttttt gagaggagtg ccaaaaacgt atgaacatga 3385021 cattgcgtct tgctgaacat agagacttgg aggctgttgt ggcgatttat aattcaacga 3385081 ttgcttctcg aatggtaaca gccgataccg aaccggtaac tcctgaagac cggatggaat 3385141 ggttttcggg acatacagag tcacgtccgc tctatgtggc cgaggatgaa aacggaaacg 3385201 tcgctgcctg gatcagcttt gaaacatttt atggaaggcc agcctataat aaaacagcgg 3385261 aagtcagcat atacattgac gaagcatgcc gcggcaaagg tgttggatca tatttgcttc 3385321 aagaagcgct ccgcattgcc ccgaatcttg gcatccgctc acttatggcc ttcattttcg 3385381 ggcataataa accaagcctg aagctgtttg aaaagcacgg gtttgcagaa tggggactat 3385441 tccccggcat cgccgaaatg gacgggaaaa gatacgattt aaaaatttta gggagagagc 3385501 tttcatgatt agtctggata aagatgaaaa cgaaattgaa catcataatg aagaaaatag 3385561 ccttgttgaa caggagactg cacctgttgg acaggagagc cgccagctga gcgcctccgc 3385621 tgtcaagtcg ctatccgaca ttgccaagtg gggcaaaatt tctggcatct tgttaatcat 3385681 tatgggatcg cttgtcactc tgtctgtttt gatgacagtg attggcgcca tcccgggcgt 3385741 actgctcatt atttcaggcg tatttttgat gcgctcagca aaagcagccg cggaagccga 3385801 aggaaatcta accggcagcg ctggcgaaag catgcttgaa aattacggga catttataaa 3385861 aatgcagctg ttttatgcag catccagtat cgttactgtc ctgatcggga tcattgtagc 3385921 cattttcgtg ctggtggtaa tcggcattgc tgcttttgag aacacgcctt cgtatgatga 3385981 tccggattct tattattatg aggatgatcc ggtgtttgaa taatgatgag acaggacagg 3386041 gcatgagttc catataaacg gaaccatgcc tattttattt gactattcaa agcaggccgg 3386101 cgtaaacacc aaatcctgaa gcaagcatac aatagacatc tctagtagag gaaatcaaca 3386161 aagcaacgct gttacccaga aatgaatatc aaaaaaacgg atgaagtcgg aatcaatccg 3386221 aaaccgcact ttttatttcg ggtgtctgca tgcaaaaaaa cacacccgga tcgtctggaa 3386281 aatctcaaca atccgggtgc agatcttctt taatacattt ttttgcgtct gtcttcctca 3386341 gtcaaaaatt caacaaaact ccgcatcgca aaaggctctt cctttatttg tcgtgcgtag 3386401 gagcttttcc gctcttctga aaggatttcg ctctttttga tcctgttcag catatagatg 3386461 tgaaccgttt tttggatttg tttatgctga tagcctgcct ctttaaaaaa tgcgagcccg 3386521 agcgccgcca aaagggcgaa tatgcctgcg ctgatcaggg actccctgtc agctgaagca 3386581 tgaaatagaa aagcagctaa attaaagaga gagaatgcag caagcggaat agcaagaaaa 3386641 cggtaaatga cggttttttt catgaaaggc tgtacggcct tttgaatttt ttgcatttct 3386701 gttttgatga accccggcat ttgttcgact ctgtaaaagt tcatataatc ctcccccttt 3386761 atttgatgtt tcaagcttca cgaacgttat catatgtgtt tattttaacg caggtgcaag 3386821 ctggttttaa agaaatctgc ccgtattttt cacgaagaat ctggatcgcc gctctttatt 3386881 cttttaaaat gtgagtgtta taatttgtaa tgggaatcag atcactgtta ttcatggaat 3386941 actaatggca atcttcttga taaatatgaa tgagcggggt tacaaagtga gtatttcttc 3387001 catcctttta tcactttttt tcattttaaa tattcttttg gccatcattg tcatcttcaa 3387061 agaacggcgc gatgccagtg catcttgggc gtggctgctt gttcttttct ttattcccgt 3387121 tttaggcttt attttatact tattattcgg ccataatctc agacgcaagc atttgtttca 3387181 atgggaagac cggaaaaaga ttggaattga aaggctgctg aagcatcagc ttgaagattt 3387241 agaaaccaag caatttcagt ttaacaaccg ggcaaccttt gataacaaag atttaattta 3387301 tatgctgatt atgaataacc atgctgtgtt tacagaggat aattcagttg acgtcattac 3387361 agatggacgg gataaatttc agcggctgct gagtgacatt tcaaaggcta aggatcatat 3387421 ccatttacag tattatattt ataaaggcga tgaattaggc aaaaaattgc gggacgctct 3387481 catccaaaag gcgaaagaag gtgttcaggt cagagtgctt tatgatgaac tcgggtccag 3387541 aacgctgaga aaaaagtttt ttaaagagct tcgcgaggct ggcgggcatg tggaggtctt 3387601 tttcccgtca aagctcaggc cgattaacct gcggctgaat taccggaacc atcgaaagct 3387661 tgtgatcata gacggtatga ccggttatgt cggaggcttt aacgtcggag atgagtatct 3387721 agggcttaat ccgaaattcg gttattggcg ggatacgcat atccggctgc aaggaacggc 3387781 cgtgcacgcc atccaaacac gattcatcct tgactggaac caagcttctc atcaccatac 3387841 gctgacatat attccaaatc actttcctga ttacggccca aaaggcaacg tcgggatgca 3387901 gattgtcaca agcggccctg attcggaatg ggaacaaatt aaaaatggct acatcaaaat 3387961 gatttcgaac gccaagcgtt ccattttgat acaaacacct tattttatcc cagatgcaag 3388021 cctgctggat gctttaagga tcgcttgcct ttcgggcatt gacgttaaca ttatgattcc 3388081 gaacaagccc gatcacgcct ttgtatactg ggcgacactt tcgtatatcg gcgatctgct 3388141 gaaagccgga gccactgtct atatttacga taacggcttt attcacgcga aaaccatcgt 3388201 ggtggatgac gaaatcgctt cagtcggcac agcgaacatt gatgtccgaa gcttcaggct 3388261 gaattttgag gttaatgcat ttatttacga tatcaccatt gctaaaaaac tggtttcaac 3388321 ttttaaagaa gatttgctag tatccagaaa attcacctat gaggagtatc tgcagcgccc 3388381 gttgtggatt cgaataaaag aatccgtctc gcggctgttg tcgccgatct tataagatgc 3388441 gtaaaccccc ggcctttacg gccgggggtt ttcctgatgg tcacagtaaa tgatgattgc 3388501 ctcccgcaaa aaagcggcaa gaccttctcc atattgattg attgaatcgg taaatcgctc 3388561 gtcagtgata tacacttccc cgagtcctct gaaaatgtcg agtgtgcaat cgtaatgata 3388621 ttggcaaata tgatcgcgaa atgcccccac agcggcctga atctctgcat catcgggccc 3388681 atgcttcatt cgcgccgcaa ttcgtctgta aatcgaatca aattcagcca tgatcgtgcg 3388741 ccaatcatct gccgagtatg cagatgtcct tttctctgtt tcttctgcga tttcctttcc 3388801 atacagcttt ctgacttcat cagcgtatgt ctgctggtgc tcttcaatgt ctttcatgct 3388861 taatccggca aataaatccc tcttattcat cgtttcccct ccatcaacgg acaaaagcgt 3388921 cctgtcaatt gtttgaatca tctcatccat tctttgtttt ttcttcatca atatctcctt 3388981 ttgcgactga agtgccgctt tccggtcaaa attcggatga tccagcatct ctttaatctc 3389041 atccagacga aacccgattt ccttgaaaaa taaaatctgt tgcagtcttt ccaggtctgc 3389101 gtcactgtac aaacgatacc cagcatcagt aagcgctgaa ggattcagaa gctcaatatt 3389161 gtcatagtga tgaagcgtcc gaatgctaac gcctgatatc tccgccactt gtttaacttg 3389221 atatttcata cataacacct cctctttttt atcgtaaaca atcacgcaac gttagggtca 3389281 atccccaaaa tgttattttc tatatacaaa acttctcaca aatagtgtat aaaagaaaag 3389341 tgagtatttt tttgtaaagg ggagccagta tacatgaatc ctgaaacaat gaacaaaacc 3389401 ctcatcagca tttcgaaatg gggaaaagct acaggcattt tatttattat tatgggcgca 3389461 attaccgcgc tttcaggcgc gttctttttt ctaatcggtg ccgtgccagg cgtactgcaa 3389521 attatttccg gtatcttttt gatgaggtca gctagggaag caggccaaat ggctgaacac 3389581 aatagcggac agtctgaaga cttaatgctg gagaattacg cgaaattcgt aaagatgcaa 3389641 gggatttatt tgatcgtaag cattgctgta tccattcttg cgattatcgc cttcttcatc 3389701 tttttaatgc ttgggattgc tgacggcctt ttcagcgata cgtacagcac ttattaatga 3389761 gaaaaacccg gagctggctc cgggtttttt attattccgc ttcgcttacc actgtgaagc 3389821 gttcattttt gtgttcggga tgttcaagct cgtccaacac ggcaatggca taatctgcat 3389881 agctgatata gctgtctcct tttgcattta cgatgacatt gtcttttcct ttttggtaag 3389941 agccagtccg ttttcctgct ggatcaaaaa atgccgcagg actgaggaac gtccaggaaa 3390001 tggagtctgt ctgctgcaaa tctttcaggt tctcgccttg atttgatgca gttggcaaat 3390061 attctttcgg aaattccggc gtatccatta aacgggttgt tttggcttca tcaacaaaca 3390121 ggcttcccgc tccgccaaca acaagcaatc ttgtgtgctt cgcgtccttt aaaatgctga 3390181 tgagtgctct tcctgcttca acatgaagat gttcttggcc gggtgctgct ccaaaagcgt 3390241 ttacgaccgc gtcgaaaggc ttgatgtctt ccgcagtcag ttcaaacaca tctttttcca 3390301 aaatcgctac gtcttgctcc tgcacttttg aagcgtttct gacgatggct gtcacttcat 3390361 ggcctctttt tttcgcttct ttcaaaatct cgtttcccgc tttcccgctt gcgcctataa 3390421 taccaatttt catttttcat ttcctcctta tttgtaacaa ttttagttac atgttagcgg 3390481 tgagaagtca tcccttttga ttaaaagaga tgattcataa catcttttaa tgacttgctt 3390541 gccagttcat tttccatcgc tctttgcaca ctttcaaacg tttcatccag agcgttctga 3390601 atttttttcc ctaccggaca tttcggattc gggttttcat gaaccgcaaa gagttcttct 3390661 tgcttttgga cagcccggta cacttctaaa agagaaatat cagcaggatc ttttttgagg 3390721 cttgcacccg gcaccccggc gcgtgatgtg agaatatcag cttttttcag caggctgatc 3390781 attcttcgca caactaccgg attcgtgttg acactgtctg caatgatttc tgaagatgtt 3390841 ttttcatcca tcgagatgag ggataaaata tgaatggcaa cagcaagacg gctgttaatc 3390901 atgttttttc accaccgttg taactataat agttacattt gattcgtttg tcaacatcta 3390961 atatacacta aatacatggg ttttgtgcac cgtttttagt caatagaacg gccggatgca 3391021 ctccggccgc gtcttatcaa aataagaaat atctttgtcc aagtgggaca taatcgacag 3391081 gctggcaaga caattcctcc ccgtcagcaa agacctgata ggtttttgga tcaatctcaa 3391141 tcttcggcaa agccgaattc agcttcatat ccagcttgct cagctttctg atatttttga 3391201 ctggagaaat ccttttttcc agccctaagc tttccgccac accacgctct atgcttgcct 3391261 gagacataaa tgtaatcgag gttgagcggt tggcttttcc gtaagacgca tacatttggc 3391321 gcatgaaaac cggttcagga gtcgggatgg acgcgttcgg atctcccatt tgcgcacgtg 3391381 caatcatgcc gccctttaag accagttccg gtttcacgcc gaaaaatacc gggtcccaca 3391441 gaacgagatc agcaagcttc cctttttcca ccgagccgac ctcatggctg agcccgtgcg 3391501 taattgccgg attaatcgtg tatttggcaa tgtaccgttt tgcgcgcaca ttgtcattcc 3391561 cgttttcacc ggcaagagcg ccgcgctgtt ttttcatttt atcggctacc tgccatgttc 3391621 ggatgatcac ttcaccgacc cgccccatcg cttgggaatc cgatgatgtc atgctgatcg 3391681 cacctatatc atggagaata tcctccgcgg caatcgtcgc cgccctgatt ctggaatggc 3391741 tgaatgccac atcttcaggc actttcgcat ctaaatggtg gcagaccatc atcatgtcaa 3391801 gatgctcatc catcgtatta acggtataag gaatggttgg cgttgtagat gacggcagaa 3391861 tgttcgcgta agaggcgagc ttcataatat ccggagcgtg accgccgcct gccccttcaa 3391921 tgtgataagt atgaataacc cggtccccga tcgcgtcgag cgtgttttcc aaaaagcccg 3391981 cttcgttaat cgtatcggta tggatggcaa cttgaatatc agcctcgtcc acgacttcca 3392041 tacacgtttt aatggcgctt ggcgtcgttc cccagtcttc atggagctta agaccgatgg 3392101 cgcctgcttc cacctgctcg atcagcggcg ctttatcgga tgcattccct tttcctaaga 3392161 agccgacatt gatcggaaac tcctcggccg cttccagcat cctcgccata taccacgccc 3392221 cggacgtaca tgttgtcgct ttgcttcctg tagcgggtcc tgttccgcct cccaaaaggg 3392281 tcgtcacacc tgaagaaagc gcaacttcca tctgctgagg acaaataaaa tgaatgtgcg 3392341 tgtccactcc cccggctgtt aaaattttgc cttcaccgga aatcacctct gtccccgctc 3392401 cgatgaccat gtgcggatcg actccatcca tgatatcagg atttccgctt tttccgacac 3392461 cgacaatccg gccgtctttc acaccgacat ccgctttgac aatgcctgtg taatccaata 3392521 gcacgacgtt ggtgataacc aaatccaaag cgccgtcctt ccctgtgatt ctgccgtttt 3392581 ggcccatgcc gtctcggata gtttttccgc cgccaaagat catttcttca ccgtatactg 3392641 tgaaatcctt ttcgacttcg atccataaat ccgtgtcgcc caatctgatt ttatcgcccg 3392701 ttgtcgggcc aaacagttcc gcatattcct cccgtgacat tttcatcgga ttacaccctc 3392761 catccagccg gcttgtttta agttggccaa cgttttttct ttgccgcgtt catcgataaa 3392821 cgtgtcggcc attccgttca gccctctaat tgtcttgcgt cctctgattt ccactagtga 3392881 gaccgttttc tgctctcccg gctcaaaacg gaccgacgtg cctgatggaa catcaagacg 3392941 catgccgatc gccagctcac ggtcaaataa taaagccccg ttggcctccg caaaatgaaa 3393001 atgcgaaccg acttgaatgg agcgtgatcc ggtgtttttt accgttacct cccgtatctc 3393061 acggccttca ttaatcgtaa tggttccctc agcaatttga aatgctcccg gcttcatgac 3393121 ttcacctccg cagaaattgg ctgatgtacc gtaacaagct ttacaccatc cggaaatgtg 3393181 gcctccacct gaatgctgtc cagcatctca ggcacaccct ccatcacatc tttttccgtt 3393241 aatacatggc ggccggcttc catcagctct gctactccct tcccatcacg tgcgccttcc 3393301 ataataaagc aggtgatata agcagcagcc tcaggatagt tcagcagaac gccccgcgcc 3393361 tttcgctgtt tggctaattc ccccgctgca aaaatgagca atttctcttg ttcaactggt 3393421 gtcagtttca tctgtagtcc tccttctttt gtcatataaa gcagatgcgg ctactacgaa 3393481 tttgcggaac agtcaggcgg gacatcacct ccctttcttc gagaatgggg gtcatacggt 3393541 aagatgcctt tcaaagcggc atgccgtttc ttcatcagcc ttgccatggt caacaaccgt 3393601 tcccctgtcg atcacggaaa gatcagatta acgcgttttc cagactgcgc tcgactaaga 3393661 taacaaatgt ctttttttct ggaaatttct ataataactt gtctgactag ttcgacaatt 3393721 aaaatctgaa ttccttccaa ttgtttatta agtaaaatat ttttcagatt taccatcagc 3393781 gctctggtga ttgcaagctg ctgctgttga ccgccttttc gttttgaaca aacgtttgat 3393841 taaaacaaat agccccctct gtttagccgg agtcggccta atacagcgac aatctgcccc 3393901 gggcgaagct aaggctgtgc aaaaccatcg attgatcata accagacgtt acattcctga 3393961 tggcagcccg ttgttttgct ccgcaaccgg aagcatggca tggaggccag tctgaggcgc 3394021 cgacctccac gataccgaga acccgactat tgccattaac tccgcatcat ggacggtcac 3394081 ttcgctgatc gccaccgttc ctcttaatga gtgaagaatt ccggccttca ctgaatcccc 3394141 gcttgtgtcg atatcaactg ttttctcgca ctcccgtggc ttccgacact ttcttcggtg 3394201 cagtacattc cgtcatcaaa acccctttgt ttgatttctt caaatgatgt tataaaagtt 3394261 tacaacttat gtcatcatta tatagaagag gcctattaat tcaaagaata tttaaaaaat 3394321 ttagttacct tgaccaaatc agcttctttt tttgttatat ttattcacat cagaaaaagc 3394381 gaaaaaaaaa gacaagaaac atttcgtttc ctgcctcttc cgtacgatta atctttatct 3394441 gaaaatttat ccttggcttt cccgatatcc ttttggattt cgccttttgc cttatctttt 3394501 ttgccttcag cctgcatgtc cgttctgtca gccatatctc cgactttatc cttcacttct 3394561 cctttggctt tattgaagcc gcccttcatt ttgtctttta cactatcgtt acccatgtta 3394621 attctcccct ctcaattatg tgtgtacttg ttaacttccc gatctgagag gcaataaaca 3394681 ttctaatgtt atttatcgat ttcgtagcgc tctccgtaac ggagcacctt gtatatcgcc 3394741 agcccgtctg atgacttttt ctccgaatat cggaccggca gcagggcaaa aaacacataa 3394801 tacgtagaaa aatagacaaa ctgatagaaa aacacattcg gctttaatac actgtgtata 3394861 atcagcagat tgattgcaaa aatcgtgatg aggttaaaca agcagccccc tgcatacacg 3394921 agtgcatttg agaatcgatt gtcaattttc aactccccgt accggcaaaa agaatcgata 3394981 aaataaatcg ttctgaaccg tatgggtcca attttaagca gcgtttttcc catgcctata 3395041 tccaacgatc cctttccgcc aaaaataaaa gccataaagc tgtgccctga aacatgtata 3395101 atctgtacaa gcggcagaac aatgaggaaa gaccacagaa acttcaccat atcattaaaa 3395161 ccaaacattg aattccccct cacatgcata tctgcatccc aaaacggctt ttgttcaaaa 3395221 aacagtgctg tagcgatttt tcctgttctc cccggaaata aacgttccga tgctcccctt 3395281 tttttgcata aaaaaaaacc atctgccagc agatggtttt gtctcatact tcatataaac 3395341 aatcgttcct ttgaatcatc tctctcatgc tgaccgcttt ttcataaaaa tacaccgctt 3395401 ctttatattg ttcgcgatga ctgaaataag aggcagcatc taaagcaaat tcttcaatat 3395461 atacatacag gcccttttct tccatataat caaatacttc ttgaatcata ttcaaattga 3395521 cagattccac atataatgcc tgcagaaatt tatattttgc cagactgaag aagtcgtttc 3395581 gtttttgggc aatggcaatc cctttttcat agtaccgtat cgcggcttcg ctatcttgtt 3395641 ttttgaaaag aacgcgagtc aggctgaaga gcgcttttgg aagctgttcc agctgataat 3395701 cctcgaagac aggaagcgct ttttcaaagt attcggcggc ctgatccagc tcccccttgt 3395761 catcatagca attaccaata ttataaaggg ctgatccgat caaacggggc tgtccttcca 3395821 ataaagcaag gcgatacgcg tcatctaaat gttcaagcgc tttttcataa tttctgtagt 3395881 caatgtagtt tcctgatatg acgaaatggc attgaattct tctgactctg taaaaatcgt 3395941 gagccttata cgtctccagc gcctgtacgg catggttcat ggaaaagtgc gtctgcttca 3396001 taatataaaa gacttccgcc actttaaaat gaaattccgc tctttcaatt tcatcttcta 3396061 caaacgcaag catcttctca gctttccgat aaaaggatat agccgagatg taattgttct 3396121 gttcaaattc gtacattcct ctaaacaagt gaaaataata ctcagataat ccggagatgc 3396181 tgtcctgatt gctttccagc gttttgatca attcacgata ttgaagctga gattcctcgt 3396241 gcaggtcagg ctttacataa tccagcataa tttggtgccg gtagctgatc agctgataat 3396301 acaggagaag cagctgatcc tcttccatct gttcgatatc tagatcaatt tcttctttca 3396361 gttttacggc atcagccact tgaaatgcta aaatgtgctt ataccactta ttgattttca 3396421 ctcctacttg agatgacggg atctcgtacg cggccatgcc cctccaaccc tttctatttt 3396481 ctaattggtt atattttatc ataatgtatg gctttggaat taaattttct tacaatgatt 3396541 ccttctttat gcctatcctt atatatttcg gtttttctac gtattttttg cactcggatt 3396601 ctaataaaaa agcttaccgg acagtgccga taagcttttg acttcaaatt aaccgccaat 3396661 ataagacatt tccactttct ttttgccaga tgcttttgat agcgtacgat cgactgaata 3396721 ctgatcgatc cgatttttcc atactgtccc gatcatttct gatagttcgt catcacttaa 3396781 ttcctggcga accggagctc tgaggtcaaa tccgcttgaa gcgaataagc aggtaaacag 3396841 ctctcctctc gcagaaagac gggctctgtt gcaagatccg cagaatgcat cagatacaga 3396901 tgatatgacg ccaatttctc cggagccgtc caagtagcgg aatctggaag ccacttcgcc 3396961 tatataatta ggcgctatcg gctcaaccgg catgtgttta ttgatcaaat ctatgatttc 3397021 cgcctttgtc atgacgtctt tcttttccca ttggttggtg ttgcctacgt ccataaattc 3397081 aatgaatctc aggatatgcc ctttttcttt aaaataacgg gccataggca gtatatcttt 3397141 ttcattgacg cccttttgaa cgaccatatt gattttaaca ccgagccccg cttgcttcgc 3397201 cgcttcaatg ccttccagca ccttgctgac agaaacaccg cgcccgttta tcttcttaaa 3397261 acgctcgtct tctaaagaat caaggctgat cgtaaccctt ttcagcccag cctccttgag 3397321 cctcttagca taaacaggca gcagtgatcc gtttgtcgtc atcgcgatgt cacgaatacc 3397381 cggtatgcgg gccagttttt tgattaattc cggcatatcc tttctcatga ggggctctcc 3397441 gccggtcaag cggatttttt caacgccaaa tcttgtgaca aacaatgtcg caagccgttc 3397501 cagctcctca aatgaaagca gctcctcttt ctttaaaaaa ggataatccg ggccgaataa 3397561 ttcggcgggc atacagtacg tgcatcggaa gttgcagcgg tctgtaacag aaatgcgaag 3397621 gtctctcagc ggtctgtttc ttttatccaa catctgacgc gactctgtaa tcatagctac 3397681 agccccttcc tactccctga ttctctcagg gtgtgtatat acattaaatg atccgtttct 3397741 gacaaatcca atcgctgtga tattcaattc ttcagccatt tgaatcgcaa gctccgtcgg 3397801 ggccgatttg gaaatgacaa tcgacacgcc gattttggcc gcttttaaca ggacctctga 3397861 tgagattctg ccgctgaaca caatcagttt gtcgcgtacg gacatcccgt ttagaaggca 3397921 gtgtccgtat agtttatcaa gtgcgttgtg ccgaccgata tctgtgcgca tcaacagaag 3397981 cttctctgtg tcgcaaagcg ccgcattatg gacgcctccc gtatcctgaa acgtcccgct 3398041 cccttgctgc atgtctttca taagcgccag acatgcctca ggcgatatct tgatttggct 3398101 gacagccgtc ttggctgttt tgacatcctg ctgaaaataa aaatgacggc cctttccgca 3398161 gcatgagccg atcacccgtt tcgtataatc cttttgatcc aatgtctcag ggtgaacgag 3398221 gtcgacatat acaaaaccga gactttcatc tattgtaaac cttttaattt ctttttgaaa 3398281 tcgtataaca ccctctgatg cgagaaatcc gatgacaagc tcttcgatat gctcaggcgt 3398341 acaaacgagc gtcacaaatt cactgccatt cagtatcact gtcaaaggga attccgtcac 3398401 catccggtct tctactttgc ttatttcccc ttgttcatag cgccatacat ccctgaccgc 3398461 agttacttta tcgttcaatg tctcttcccc tccgcaatgt tcctgccttt atattttttc 3398521 acactcctcg gattttgtcg aattctgaga cacaaaaaga gccctctata taaagggctt 3398581 ttacaggatg tgatgacggc ggtgtttagg caggacgcct aagcatttag ccgccgttcc 3398641 ttttataaca cgtgagcacc aatgtgcatt gacaacgaac gcggggtttg tcgacacgct 3398701 gagacacctc tgtataaagg actctatgtt tgattatgct gattcttttt cagaaccgta 3398761 aacagcacaa tagctgcgat caaggtgaga atgctgacaa aaaagaaggc tgccagtttt 3398821 agaagaacac caagcaatat aaatgcaacg gtggctataa gaaaaatcat tccgaataat 3398881 ttcatatgtt caaccccttt ttagggtatc attcccgccc aaactgtttt taaaccaata 3398941 aaaaaggcgc ctgggggagc gcctgatctt taggttcctt actcagtaaa tttttgtgct 3399001 tctttttccc aagcctgttc gaactcatcc gcactgttcg ctgaaatata ttctccgccg 3399061 ccagcgacag ctgcttgttt catctcttca ttacccttga catcaaagtt gaagccaatg 3399121 atgtttacaa tcgtatccac atttgatgca cggagctttt cgatttccgc cgcagggtct 3399181 ccgccgcacg tttcttcacc gtcagtgatt aaatacacca cgtttttccc gtctgcgtca 3399241 aatgcttcaa attcttttct tgtgtctgca agtgctttgg caatcggtgt ccatccagtc 3399301 ggcttgagct cactcaatga attgtcaaac agagaccctt catatggatg aaggccgtaa 3399361 atggtttccg tcgtactgca cgaaagggct ttaccggaca gtttattgtt ccctgcatgc 3399421 ccgaaaacgc gaagcataag atttgtatcc tttggaagaa gttcggcaaa agattttact 3399481 gattttttgg caatgtctat tttgcgctct cctcctgttt tttgaaccat gcttccgctt 3399541 ccgtcaaaca aaacagctac atttgtatca gcctgtttct cagcggcaaa agacggggag 3399601 gcaatggaaa cagtcaacaa tccaatgata ccggcagcca gcaatttttt catatgatta 3399661 cttcctttct ttttcatatt ttccaactat atgttggatt cttctttatg ctagaatacg 3399721 aaaatgcaaa aagatatagg acatgctgcc ttttgtgctg ctttcacgat ctgtccaaaa 3399781 tcgcttgaaa tgccgttcat ttttagccat ttccgcccag aaagcataaa cagcttgtgt 3399841 gatcattcat tcttttttcg ccttgattat gacagaaaaa cggaaatctg ctactatgct 3399901 acaggcagac agctaattag ttttgaagtt tttgttacat acaaaaagag gctgaccatc 3399961 accagcctct tttttcttat ttagataaca ttagtgattg ctgagtgaaa attttctcaa 3400021 catctttttg ggtataagcc gggaagtatt caccgccgcc tactttcgca attgcgttca 3400081 gctggccttt gtatccctct ttataatcaa agccgatcac attaacagtg atattgtctt 3400141 tttgcagttc ctttgctgtt ttaatcgggt ttcctccgca cgtttcctca ccgtctgtca 3400201 acagatacac cactttttcc ccttttgcat caagctggtc aaaagaagat ttcgcctcgt 3400261 tcagcgcttt ggcaattggc gtccagccag tcggcccaat tgtattgaga gaattgagga 3400321 agctttgctc gttaaagctt tggaagccgt atacgttgcg aatggcttca catgactgaa 3400381 cttttccgga atttttattg tttccttcag agccaaacac gctcattttc acctgagttc 3400441 cttctggcaa tgagctcgca aactttgaaa tttctttttt ggctgaatta aatttagata 3400501 caccatctat tcttttcgcc atacttccgc tggcatcaag caagaccgcc acgttcgccg 3400561 gcgctttagc ctccgtttct gtcttttcag ctgcaaaagc aggtgaagtt aatccaaaaa 3400621 gcaatcctgt catcatgatc agtgaaaatc ttttcttcat gttcgtaccc ctttaccaat 3400681 ttgtttctgc gtgcagatgt tcaacgctga acataatcta tcgtaatcaa caaaaaccga 3400741 gaaataaata gggcgggctt ccccattgct gttgtttact tttgcataga aacctatgtt 3400801 tttattagtg atttccacct aacgccccta tgaaaagaga agattgtccg cctttcggct 3400861 ttcgttatat gagtctgtcg aagtctgtcg acaaatgtgg atgactttac cacaatctca 3400921 aagcctgaaa tcaggaaaaa aggactgatc cttaaagacg gtcagaagct cctctaaacc 3400981 gtttcagcta ctcttagata aaagatattc aggaacagaa aaagacgccc aatgagcgtc 3401041 tttttctact ttttcgccat atatttattc aaaaacgcat ctgcctcaga aatttgtgtg 3401101 ccttggtaat agtactttac aatgtcatca accgttttgc cttctttggc cataaaattc 3401161 gctccgtatt ggctcatccc cacaccgtgg ccaaatcctc tcgtcgtgac tgtaattgtg 3401221 tctccatttc gcttccattc aaaatcggcg gagttgagac ccaacttttc acgtatgtct 3401281 cttcctttca gcgtcttgcc gttaatgacg gcagttgcga cctggtggcc cggtgtctcg 3401341 ccggtaatct tccctactgc gctagatcca tccagcttga cgccaagctt ttgctgaaat 3401401 tctgccgctg taaaggtttt cgttgcctta tatttcggag actttttatc ccatgggctt 3401461 ttgacgcttt ttaaatatgg gatagcactt gtccaataag cttctgcatt ctctgtgtag 3401521 ccgttgcttg tggagaaaaa ggatgcttca atcggctggt tgttgtacgt taagattttg 3401581 ccttgcgtac tggctaccgc atctgtgatt ttcttcagtt ttgtctcata gcttgtgccc 3401641 cactgttttt tcagctccgc tttgctttta tacacctgga acatctgtgt atcatccacc 3401701 agtgagcctt taggagcttc taccgctgaa tttgacacca tcagtctgac aataaatgtt 3401761 ctggcggcaa gcgcctgggc tttcagcgct tcaggtttaa aggttgccgg catttcggag 3401821 gcgacgactc caatcacata ctcttcaagc ggaatgtttt ctacggattg atttgcggtt 3401881 cgatagacgg gaatagaaac aggtgatgct ttcaatgttt ctgctccttt cgatgctggt 3401941 ttcgtgctga ctgctgtctt ttctgattct acgctggccc ccgcttcctt attatgctgg 3402001 aatggtataa ccaagagtgt gggaaccaag agaatcaatg cacatagtac ggatagtgtg 3402061 attgcgaatt gtttcatatt cagctgcctc ctgctcggga ttcgactcta gtctagtcta 3402121 tgggcaggga caagctaata tgactctcgt tttggacaga aactttattt gtcatttacg 3402181 tattcttttt tgctattttg cgcataatga tgataataca caaaaaataa aaaaccagta 3402241 tgccagagtg acatactgat tttcaagtaa gtttatgcat ttaagtcaga aacgacttct 3402301 ttattctctt gctcagaagc agactcatca tttacacgtt cgatgtctgc gcccagagcg 3402361 gcaagcttct gatggaaatc aacgtaaccg cggtctaagt gcttcaattc agtaacacgt 3402421 gtgtgacctt cagccactaa ccccgcaaga atcagcgctg cacctgcacg caaatcagtc 3402481 gctgcaactt cagctccctg aagctgtaca ggaccgttaa tgatgacaga acgtccttca 3402541 atcttgatat caccattcat acggcggaat tcttccgcat gcataaaacg gttttcaaaa 3402601 acggtttctg taatcatgct tgtgccgctt gcacgaagca gaagcgccat catttgtgac 3402661 tgcatatcag tcgggaagcc cgggtgaggc attgttttga tgtcaatcgg tttaagctct 3402721 ttcgggccga tgacacgcag accttcacct tcatccttaa ttgttacacc catctcttcc 3402781 atttttgcaa ttaaagaggt gaggtgctca ggaaccgctc cttttactaa tacgtttcct 3402841 tcagtgattg cagcagcaac cataaatgtg cccgcttcaa tacggtcagg aataatatgg 3402901 tgttttacgc cgtgaagctt ttcgactcct tcaattttga tggtgccggt gccagctccg 3402961 cggatttttc cgcccatgcc gttgatatag tttgctaaat caacgatttc gggttctttt 3403021 gccacgtttt ccagcgttgt tgttccttca gctagagcgg ctgccataat caggttctct 3403081 gtagctccta cacttgggaa gtccagataa atttttgcgc cttgcagtcg gccttttact 3403141 tcagcttcaa tgaagccatt accgactttg atttctgcgc ccattgcttc aaaacctttt 3403201 aaatgctgat caatcggtct ggaaccaatt gcgcatccgc ccggaagtgc aactcttgca 3403261 tgacctgtac gcgcaagaag cggccccatg acaagcacag acgcacgcat tttacgaaca 3403321 tattcaaaag gtgcttcagt ttgcaaagcg tatgaagcat ttacagtcac ttcattattt 3403381 tcaaaatgca catctgctcc taaatgacgc aacacttcgt taattgtata tacatcggag 3403441 agcgtaggta catcacaaat tacgcttttt tcttcacttg ctaataaaga tgcagcgata 3403501 acaggtaaaa cggcattttt agcgccttca actttgactg tgccgtttaa cttctgaccg 3403561 ccgcggacga tgattttttc caaggtattc ccctccgcgt ccctaaattc tctatattaa 3403621 tattcagtcg taacgattgg tgtgccaacc gtaacggtat gttttccgcc cattcctgca 3403681 cttctaagtg caatttgcaa attcatttta tgtttcgagg tcataatgta ctcttcccac 3403741 tcatctgtaa acgcagaaat agaaacgaaa tttggctcaa ctacatgttc tactgatctt 3403801 gcttgaaatt catttaataa ctgatttgct tttttttgca aaacaatatt catattatca 3403861 tctaagtgac catttagaca agtaaaaata actacttttt cttggaatat cccaagtgtc 3403921 tcccgttcaa actgttcata tgtatcattc cagctatccg gtgtctctag actcatttgc 3403981 tcatataata aatacgaagt tggattgtgt tttttgaggg ttgtgacaag ctgcagtcta 3404041 aaagaagtac gatttttttt gtcagtatat gtgccaattg cctttatcat tttatcttcc 3404101 cgtgcaatca cccaatcata ttgacgatac tcttgtttta aacgttgcac tttttgataa 3404161 aattcttttt cggtcagtga caagttttgt tttgcatgca atgtccactt atctattgac 3404221 acatcttgac gttccatccc ctctgccatc tgtgctaacg gcgttaattc actcgcatga 3404281 atggtatgga aaacagcaat gacgaagctt aacatgacgg aaatgataat agcgtggctt 3404341 acttgttttt tcttcatgtt catctctccc ccttatcccc agttttaccg gaggcaagag 3404401 gcgccatacg taaaaatctt cgtcaaaact cgagctattc gcttcaaccc gcttctccca 3404461 accatttaat aatgttcaaa acctattaaa atagataggg aagctgctgt gaataattga 3404521 ggtaatctaa aaagaaattg gcaacggccg ttccaatggc gattgtcagc aaaatcatca 3404581 ggagtcttgc ctgcacgact ttgccttttt tgattaacgg atctatattg acggcttgca 3404641 acgcccacca agtcactgct ataaaaatca ggtgaacgac aatgccgatt gcagcctgct 3404701 gtcccaatac actcatctat tacactcctt tctctgcgtt catacccttt cttattatat 3404761 aagaagcaca gataaagatg atacatttta tacagaacgg aataatcagc caaatctagg 3404821 gctaatcccc gcttaaagtg cgattctttt acatggtata ctttattgga aaggagctgg 3404881 caaatgtgaa tcattctttt tttcagcctg aaaagcaata tggtgaggac ctgccaattt 3404941 ttgatcagga atgggaagca attgcattct attatgatta tagacagtca cagattgaag 3405001 aactgaatga attgtgtcag ttttttaaca tttctcttac ctatacgaga gaaagccttg 3405061 aagagcttga aaacctctat tttcaaagta tacaagaact tttgcttgct gattggaatc 3405121 ttcctattga agaattcgag aaaatgatca gtgtttatct tatagattgt gtgattgccc 3405181 gccatgaaga tgctgaatgg gttgtaaaac cttatcccta taaagacggc gcttatacac 3405241 ttggctttag aagacatcgc aaatcgtggc atacaatgaa tgcctgtgat ggtttatacc 3405301 tgcgtccaaa agaggatcgc ccgttgctgt cgctgtttga ttctcttgtg cgttcataaa 3405361 aaaatccttc tcataaagag aaggattttt tcttatttcc ctgctacatc caatctgttc 3405421 aaagcccgct gtaacgcaag ctcagcccga cgaatgtcag tatcatctga ttgagaattc 3405481 aaacgctcct gcgcccgctg gcgtgcagct tcagcgcgct ctttatcgat gccttccgct 3405541 gtctcggcag cctgggcaag gatggtgaca tgatcaggac ggacttctac aaaaccgccg 3405601 ctgacggcaa ccatttcagt ctgcccgtct tttttcagac ggacagcgcc gattttaaga 3405661 ggagccacgg ttggaatatg gcctggcaaa ataccgagat cgccgctttc ggctctcaca 3405721 ctcaccattt cgatatccgc atcgtatact gggccgtcgg gagtaacgat attgacttta 3405781 acggtcttca tgcttttacc ctcctaggac cagattaaac ttctacaccc atttcttttg 3405841 ctttctcaac aacttcttcg atacggccta caagacggaa tgcatcttct ggaagatggt 3405901 catatttacc ggctaagatt tctttgaagc cttgtaccgt ctcttttaca ggcacgtaag 3405961 aacctttttg tccagtgaac tgttcagcca cgtggaagtt ctgagaaagg aagaactgga 3406021 tacgacgtgc gcggtgaacg acaagtttgt cttcctcgcc taattcatcc ataccgagaa 3406081 tcgcaatgat atcctgaagc tctttgtaac gctgaagcgt tgactgtact tcacgcgcaa 3406141 ccgcatagtg ctcttctcca acaatttcag gagcaagggc gcgtgatgta gatgccaacg 3406201 gatcaaccgc agggtaaata cccatttcag ttaatttacg ctcaaggttt gttgtcgcat 3406261 ccaagtgagc gaacgttgtc gccggcgccg ggtcagtgta gtcatcggca ggcacgtaga 3406321 tcgcctggat agatgtaact gatccaacgt tcgtagacgt gatacgctct tggagctgac 3406381 ccatctcagt tgcaagcgtc ggctgataac caaccgctga aggcatacgg ccaagaaggg 3406441 ctgaaacctc tgaacccgct tgtgtgaaac ggaaaatgtt atcgatgaag aacagtacgt 3406501 cctgtccttg tacatcacgg aagtgctcag ccattgtaag gcctgtcaaa gcaacacgca 3406561 tacgtgcgcc cggcggctcg ttcatttgtc cgaataccat ggctgttttg ttgattacgc 3406621 cagagtcact catttcgtag aaaaggtcgt tcccttcacg agtacgctct cctacgccgg 3406681 cgaatacaga gataccgccg tgctcttgcg cgatgttgtt gattaattcc tggattaata 3406741 cggttttacc tacaccggca ccaccgaaca atccgatttt accgccctta atgtaaggag 3406801 caagcaaatc aacaacttta atacctgttt caagaatttc aacttctgtt gaaagctgat 3406861 cgaatgaagg cgcctgtctg tgaatcggat cctttttcgc atccgcagga accggctcat 3406921 tcaaatcaat attttctccg agaacgttaa atacacgtcc aagtgttaca tcaccaaccg 3406981 gtactgagat tggcgctcct gtatctacag cttccatacc gcgctgaaca ccatctgtag 3407041 atgccattgc gattgtacgg actgtatcat cacctaaatg aagagcgacc tcaagcgtta 3407101 aatcaatacc tacttcgttt tcacttgcag ctggctgtga aattttaatc gcattataaa 3407161 tttcaggcaa gtgaccgtct tcaaaacgca cgtcgacgac cggtcctaat acctggctaa 3407221 cgcgtccttt cttcatcgct atccctcctg acaaaatctt tctattctaa agcggctgct 3407281 ccgccgacaa tttccgtaat ttcttgtgtg atggctgctt ggcgagcgcg gttgtaagaa 3407341 agcgaaagtg aatcgataag ttccttcgcg ttgtctgtcg cgtttttcat cgccgtcatt 3407401 cttgcagcgt gctcacttgc tttactgtca agaagcgcac cgaagattaa gctttctgca 3407461 tattgaggaa gcaaaacctc cagaacctcc tcttcagatg gttcaaattc ataagacgcc 3407521 gttctttttc cgccgccgct gcccaaatca gataacggca gaagtttttt ctccgttact 3407581 tcttgagtaa tggcgctgac aaaatggtta taaacaaggt gcaattcatc aaacgcaccg 3407641 tctataaaca tttgaatcgt ttgacgggca agatctttaa tttctgtaaa cgttacttca 3407701 tctccaagtc ctgttaactc ggaaatgatc ggaatctccc gtttcttaaa gaaatcacgg 3407761 cccactcttc cgatggcaat caccgcatac tcatccttag actgatgacg ttcttgcatg 3407821 gcctgataag cactccgtaa aaccgaactg ttaaaagcgc cggcaagacc gcggtcagac 3407881 gtaatgacaa ggtatgccgt ttttttcact tctctgctga gaagcatcgg gtgcttcacg 3407941 ttgccggaaa ctcttccgac gtttgacaca acctcttgga ttttatccat atatggcaca 3408001 aatgattttg cattgttttc agcacgattc agcttagccg cagataccat ctgcatggct 3408061 tttgtaatct gacttgtttt tttcgttgac gtgatccttg acttaatatc gcgtaatgag 3408121 gccaaagatt tcaccacctt ttctcttcat ctgcgtaaaa agagagaaaa agagaacctt 3408181 tttctctcat cagcattcga gttagttgct tggtgcaaat gtgcgtttga agccttcgat 3408241 tgcagctttg aagtcttcat cagcaggaag gtttcctgtt ttcgcaattc cgtcaagcag 3408301 gtctttatgg ttttggtcaa ggtacatgta gtactcttct tcaaaacgtc tgatatccgc 3408361 cacaggaata tcatcgagat atccttttgt cagcgcataa agaatagcta cttgcttttc 3408421 aaccggaagc ggcttgttca gatcctgctt cagcacttca actgtacgcg caccgcggtt 3408481 cagttttgcc tgagtcgctt ggtcgaggtc agaaccgaat tgagcgaatg cttccagctc 3408541 acggtatgac gcaaggtcaa gacgcaaagt acctgatact tttttcatcg ctttgatttg 3408601 cgctgagccg ccgacacggg atacagacaa tccggcattg atcgctggac gtacgcctga 3408661 gaagaacaaa tcagattgca ggaagatctg tccgtcggtg atggaaatga cgttcgtcgg 3408721 aatataagca gagatatctc cggcttgtgt ttctacgaac ggcagagctg taattgatcc 3408781 tgcgcctttc gcgtcgctaa gctttgctgc acgctcaagc agacgggaat gaagatagaa 3408841 tacatcccca gggaacgctt cacggcctgg cggacggcga agaagcaagg acagctcacg 3408901 gtaagcggcc gcttgtttag aaagatcatc gtatacaaca agaacgtgct tgccgttgta 3408961 cataaattct tctgccattg taaccccagc atacggtgcc aggtacagaa gcggtgccgg 3409021 ctgtgacgca gacgccgtta caacaattgt ataatcaagc gcgccgtgtt tacgcaatgt 3409081 ttctactacg ccgcggactg ttgattcttt ttggccgatc gcaacatata cacagatcat 3409141 gtcttggtct ttttggttca ggatcgcatc gatcgcaaca gatgttttac ctgtttgacg 3409201 gtcaccgatg atcagctcac gctggccgcg gccgattgga atcagtgcat cgatcgcttt 3409261 gataccggtt tgaagcggtt catgaacgga tttacggtcc ataacgcctg gtgcagggct 3409321 ttcgatcgga cgagttttgc ttgtcagaat cgggcctagt ccgtcaaccg gctggcctag 3409381 cgggtttaca atacggccga ttaactcttc accaacagga acctccatga tgcggcctgt 3409441 tctttttact tcgtctccct cacggatctc actgaaaggt cctaagatga cgatacctac 3409501 gtttgattcc tcaaggtttt gagccatacc caaaacaccg tttgaaaatt cgacaagttc 3409561 accggccata cagttgtcaa ggccgtgcac acgtgcaata ccgtcaccga cttggatgac 3409621 tgtacctacg tcttgaactt caatatcaga ttgataattt tgtatttgct gttttatcag 3409681 cgtgctaatc tcttcagctt tgatgctcac ttaggtttca ccccttctat cgattttccc 3409741 cggctaattg acgttcaatg cgctgaagct tcccgcttac gctgccgtca taaatccggt 3409801 ttccaatgcg gactttaata ccgcctatta aatccgtctg cacttcattt ctgattctca 3409861 gtgaagcgac tccggctttt tttgcaaaca cttgtgataa tggtaacatt tctgcatccg 3409921 tcagcggttt cactgaatat acgattgcgt cttctgtttg acgggccaca tttgcgagtt 3409981 tgataaactc atctgtgagc tcagggacaa tcgcggcacg atggcggtca atcaaaagaa 3410041 aaatcgtatt gagtacggac tgtgacaaag agccaaatgc attttgaatc agctcttttt 3410101 tcttcgcagc cggcaccttc ggatggttca acacatcatt aagcgctttt tcattttgaa 3410161 atacttgttt tacaacaatt agctcttctt ctacttgatt cagctgagcg gactcattgg 3410221 ctatatcaaa aagagctgat gcatatcgtt tagagacagc tgatccactc atcggctttc 3410281 tcctacctct ttaagatagt cctggatcaa tttctcttgc gcttgttcat ccagttcttt 3410341 ttcgatcact ttcgacgcaa tcatgacaga aagagacgct acttgctcac ggagagcaga 3410401 aaccgcctgt tccttttcct tcacgatttc agttcttgct gcttctttca gacgttcaga 3410461 ttctgcacgt gcagcctgaa taatctcttc tttttgcttc tctcccagtt tctttgcgtt 3410521 ttcgataaga gtttgggatt cctgtcttgc ttcttttaaa agaacgcgct gctcttcaat 3410581 cagctgctgc gcttctttat ttttttcttc agcagacgta atttctccag cgatgtggtc 3410641 ttcacgctgt ttcattatgt ttaatagcgg ccctaaagcg tatttcttca gaagcgctaa 3410701 taagattaac atagctaaca gttggaacag gatatctccg ccgttaaacg acaatcctag 3410761 ttcaagtggt aattgagaca tctactacgg caactccctt ctgcaggttt ttctttgctg 3410821 atccagcagc cgcacttgtc tcttttcagc cggcaaggcg ggatgcttat cagacataaa 3410881 gcaatggcga aggttctctt ggaatgatct tcgccatttt tagttcatat aaggctttta 3410941 tgcttagcca aagaacgcta agaatgcgat aacgacagcg ataataggaa gggcttcaac 3411001 taatgcgata cccatgaaca taagagttct cagttcttta cctgcttccg gctgacgggc 3411061 aatcccctct accgtacgtg aaacaatcaa accgttacca atacctgcac caagtgcgcc 3411121 taaaccaatt gcaatcgcag ctgctattaa attcatgaaa aagttcctcc tttaaaatgt 3411181 tatccgtttg gatataatgt tttaatgatc atgactgatt ttatgagaca tgtacaccat 3411241 cgtcagcatt gtaaagataa atgcctggat agcaccaata aataaactga atgcttgcca 3411301 tgccagcatc ggcagaatgg caccgattgt accgacaaga ccgagagcca cgctttgcga 3411361 ataatggctt gttgctaatc ccgcaagcag gccgagaaga atctcaccgg cgaagatgtt 3411421 accatacagc cgcaaaccta gagtcagcgt attcgcaaac tcttcgatga ttttcatcgg 3411481 gagcatgaat ggaacaggtc ttaaatagtc tttggaatat tccttgagcc ctttcatctt 3411541 cacaccatag tagtgggtta aagcaacaac catcacggct agcgttaatg taatggcagg 3411601 atcggctgtc ggagacttcc accagagctc atgtccgatt gtaatagaga acggcagccc 3411661 cagcatattc gacacaaata tgtacatcag caatgtgaca ccaagtgcca agaagttagc 3411721 ccctgttttt aaatccattg tactgccaat aatattgcgg acgaaatcaa caatccattc 3411781 cataaagttc tgggcttttc cgggacggat cgaaagcgtt cttgtcgtca atatagcaat 3411841 caataaaaca atcacactcg ccacagtaat catcagaatg tttgtcagat taaaagtaag 3411901 acctagaaat tctatagttc tgtaaccatg attcaaaggg ttttcacctc tcttccattg 3411961 atgaacgttt aagctggata aaggaatcta tcataatgac agggtatatt gtcattaatc 3412021 caataactgt acttgccata tgaaagtatt cgggattttt ataggcaaca gccacagcaa 3412081 gaatcgcatt gcaccaccgc gctgcgctcc cgagagatcg tatggacttt cctttctcta 3412141 cagctctgtc aaaagcattc attcttctga cgagcagtaa aaaattaaac aaactgaaaa 3412201 cagttcccag aataaggcct aaaaaaacgg ttttatacgc tgttaaacca taacccagta 3412261 catacactgc caaaatgaac aataaatatt tgcgttgtct gctaaatgta agcttgggat 3412321 cgtccatcaa ttatctgtct cctgatgaaa aaataatgta tagcttggat acggcaaaaa 3412381 tcagcggtta acccttagta gaagaccttt tttgaccggc aaaacgggcc tgttcgaaaa 3412441 aatcattcat ccgcaagcct tgcagggatg ctgtttcatt cgcttaaata aatcctcata 3412501 atacgggttt gctgagagga tttacattga ggatgaggac tataatgaaa gctatgaaaa 3412561 ccttctcata ataccctcgt ttagcataca atagccccta acatgtgtca atctgtttaa 3412621 agttaaaaaa ctttttatac tttacgtctc cacagaatgt tcacattttc acctataatt 3412681 gtatacagat tcaccgaata gcaaaaaact ggataaaaaa atgaaacccc cttttgggga 3412741 tttcattttt tattttgttc caaacatgcg gtcacccgca tctccgagac ctggaacaat 3412801 atatcctttt tcatttaatt tttcatctag cgccgcaatg taaatatcaa cgtccgaatg 3412861 atgcttctgc aattcttcca caccctccgg cgctgctaca agacacatga aacggatatt 3412921 tttcgcaccg cgttttttaa ggctgtgaat ggcttcaact gcggaaccgc ctgtagcgag 3412981 catcgggtca accacgatga attcacgctc ttccacatca gaaggaagct tgacatagta 3413041 ttccacgggt tttaaggttt ctggatcacg gtaaaggccg acatgtccca cttttgccgc 3413101 aggaatcagc tttaaaatgc cgtcaaccat tcccaatcct gctctgagga taggaaccac 3413161 tccgagtttt ttccctgaga tgactttcga tttcgcagcc tgaaccggtg tattgatatc 3413221 cacttcttcc agaggaagat cgcgggtaat ttcaaatgcc atgagtgtag ccacttcatc 3413281 tactaactct ctaaaatcct tcgtacctgt attttcattc cgtatatatg tcagcttgtg 3413341 ctgaattaaa ggatgatcaa atacataaac ctttcccata ctgtgtttca gctccttttt 3413401 tattgtccca tcaacaatta cacacttcta ttgattctac aaaaaaagac attgagtttc 3413461 aagaacatcg tcaaaaaacc cgccgggcat aagcccaagc gggttttagg atcttaataa 3413521 tctaattctt tatataaagg aaatttatca gtcagagcag ctacacgctg tcttgcttct 3413581 tcaagttttc cttcatcttc gtggtttttc aatgcaagcg caatgatagc accgacttct 3413641 tctaatgcgt ctccgtcaaa accgcggctg gttacagcag ctgtaccaag acggatgccg 3413701 cttgttacga aaggtttttc aggatcatat ggaatcgcgt ttttgttaga cgtaatacca 3413761 atttcatcaa gtacatgctc cgcaacctta ccagtcagtc cgagcgaacg aaggtcaaca 3413821 aggataaggt ggttgtctgt tccgcctgaa acgagctgga tgccctcttt cgttaaggct 3413881 tcagccagac gtttcgcgtt tgaaatgacg ttttgtgcat atgttttgaa atcgtcctgc 3413941 aatacttcac cgaatgaaac agcttttgcg gcaataacgt gcatcagagg gccgccttga 3414001 attccaggga agatcgattt atcaattttc ttgccaaact cttcacggca aaggatcata 3414061 ccgccgcgag gaccgcgaag tgttttatgt gttgttgttg taacgaaatc agcgtaagga 3414121 accgggtttg gatgaaggcc tgccgcaaca agtcctgcga tatgtgccat atccaccatg 3414181 aagtaagcgc cgacttcatc agcaatttca cggaatttct taaagtcgat tgtacgagga 3414241 tacgcacttg ctcctgctac gataagcttc ggtttatgag cgagggcttt ttcacgcacg 3414301 tcatcgtaat caatatattg agtttcttta tctacgccgt actcaacaaa gttatattga 3414361 acaccgctga agttgactgg gcttccgtgt gttaaatggc cgccgtggga gaggttcatc 3414421 ccaagtacag tatcgccttg ctccaaaatc gtgaagtaca ctgccatgtt tgcttgtgcg 3414481 cctgaatgag gctgaacgtt tacatgctcc gctccaaaga tttccttcgc gcggtcacgg 3414541 gcgatatctt caacgacatc gacgtgctcg catccgccgt agtagcgttt gcccggatat 3414601 ccttctgcgt acttatttgt caaaacagat ccttgtgctt ccataaccgc ttcacttaca 3414661 aagttctcag aagcaatcaa ttcgatctta gtctgttggc gttcacgctc atttttaatg 3414721 gcgttaaaca cttgttcgtc ttgcgcaggt aaatgtttca tcagcgagat cctctcctat 3414781 ccgtatcctg ttctttgttt ttaccatcac tattgtacat ggtttttaag gccgatgtaa 3414841 aagattattt ttaaaaaatc taaattttta ttggtaaaaa cgaatattaa taacttaaat 3414901 ttaatttaaa gttcggaatt tatttcacta tcttaaaata aaagaaaaga ctggctatgc 3414961 agtcctttca ttcgcactca taaaccgccc gcactccgcc gattagtttc ggccgtgtac 3415021 gcgccaatgt cacatgagct gaaccgaggc tgttttgaga gacacgcaca gggacagcca 3415081 ccggtttcag atgcatgccg ataaacgtat cgcctatatc aattccggcg tcagcctgaa 3415141 tggtttcaac aagaacagga gacttcatct gcttaaacgc ataagacgcc atcgctccgc 3415201 ccgcttttgg aacgggcacg gcagaaacgg ttggaagcct gaacagcttg gctgtttctg 3415261 cttcgacgac aagcgctctg tttaaatgct cgcagcattg aaacgccaga tggattcccg 3415321 ttttttcccg gagctcagca agtccgctgt agatgctttc agcgatatct acactgcccg 3415381 atgtgccgat ccggctgccg gccacttcgc tcgtgctgca tccaaggacg aagagctgat 3415441 cttgtttcaa ttccgcttgg tcctgaaact cagacagcat cgtcttccac gtttgtttca 3415501 actcattcat taaacagcac ccctacaggt ttttctcttc ataatcggag atttttccaa 3415561 tacgcgtttg gtgtcttccc ccggtaaact cagtagtcag ccagattttt gcgatttccc 3415621 gagccaaacc aggtccgatc acccgttcac ccatcgcaag gatgtttgtg tcattatgct 3415681 ccctcgtcgc cttcgcgctg aaggtatcgt gcgccagcgc gcagcgaatc ccttttactt 3415741 tattagcgga aatgctcatg ccgatgcctg tcccgcaaat taaaatgcct ctgtcaactt 3415801 cgccgctaac cactttttcg gccaccggaa aagcataatc cggataatcg acagagccgc 3415861 tgccgcagtc acagcccata tcaatatatt caatttgcaa ttcgtccatt aactctttga 3415921 tttcatttcg aatgtgaacg ccgccatgat ccgatgcaat ggctactttc atctgctttt 3415981 cctcccagcg tgtgtgatgc ggcccgcccg ctttattgac cgcgcagcct gtccgctctt 3416041 tgattcacac catatgatgt gcttttcact atattctact ccttcacgca ggatttgcaa 3416101 atgacctgtt tgcagatttt ctgacaactt atctacggtc ttttttcagc tgttttgcca 3416161 gctgccgaag aagctcttca agctcatctc gcgtttgttt atagatgtca attgagccgc 3416221 cgaacggatc gaggacatca ccatggctgc ctgtgacata ttcttttaac gtaaacactt 3416281 tatcacgata acgtccaaat tggctggcaa tgatctgttt gtgctgatgg gtcatagcca 3416341 gaaccaaatc agccgattcc ataagttctt cagttaatgg agaagacaca tgattaaggg 3416401 caatgtgttt ttcaaacagc gcttcgactg catgaggcgt cgctttccca ttaggtgaag 3416461 caaacacgcc tgccgagcgg acattgacat tcagcccttc cctttctgca attgatttaa 3416521 aaagcgcctc agccattggg ctgcggcacg tatttccagt acagacaaaa ataatatcca 3416581 tgtcagtcac cccttatttt tctctattat atatgaagaa aaaagaaacg gcgacttcgt 3416641 ttcttttatt ggtatattaa attggcaaaa gcagctttaa tccaaacacg attaatatga 3416701 tgcccccgag cgcttcgctg tatgtgccaa gccatgactg cacttgtttt ccgaccagca 3416761 ggcccagcca tgtcaacatc atgctgaaca gcccgaacag ggtaattgtg aggagcggat 3416821 gcgagccgta tatccccaag ctcaagccga cggaaaagct gtcaaggctg acgccgatgg 3416881 caaacagcaa taagcccggc cctgccggtg acatgaatcg ttcttctgac tgtttaaaag 3416941 aggccataag catttgaacc ccaagaacaa aaagcagcgc cccaccgata taaaccgcta 3417001 acacgccgag gagccctgac agcatgttac cggccgccat ccctgcgaga ggcatgatga 3417061 cgtgaaagag gccgatgatg aaaccaatat agaatatctg cttctttcta agtttgacca 3417121 tgcccattcc aaggccgaca gaaaaagcat ccatccctaa agcaaacgcc atgatgctta 3417181 atgtaatcag ttcgcctata aacaaatccg acatacataa ataaccccct tggacacgcc 3417241 ccgctttttt agcctatgcg tgtccaaaaa gggttagaac atctgactgc tttcagcgaa 3417301 tcactcttcc tccggcggct ttcatcagcc tgttcataat agcaagaccg acacctgtat 3417361 ccggaaagga ttccgctata atgaaatcca ccttattctc atcaaagctg cgcaaagcat 3417421 catacagccc tgccgcaaca gtctcaagct gagcccgtct tccgcagctc ttcacataat 3417481 cagcggaata aacgcccgct ttttcttctg tcgtcaggac accgacccgt cttccaccct 3417541 gttgatattc ttgaatgagg tgctgaatgc gctctgggct gccttcgcaa atggcaagag 3417601 gcgctgtcgg cgcataatgt gtatatttca tccctggaga aatcggcttc tcgttttggt 3417661 cgctgagccc tttatccaca tggatcggcc cgatcaccgc ttcaatttgt tccttcgtaa 3417721 tgccgccagg acgcaagaga acagggatgt cgtccgcaca tgaaagcaca gttgattcga 3417781 ccccgattcc ggtagggcct ccatccacaa taccggctat gcggccatcc aagtcgtgag 3417841 ccacatgctc cgcttttgtg ggacttggct tgcctgatag attggcgctc ggtgctgcaa 3417901 tcggcagtcc cgattcgcga atcaatgcaa gggcaagcgg atgatccggc attctaatgg 3417961 caaccgtttc aagacctgcc gttacacgag gtgaaagcgc atcaggtttg caaggcagaa 3418021 tgagcgtaag tgctcccggc caaaaccgtt tcatcaatgt tttcgccttt tccggcgccg 3418081 ggcccgttaa atcctcaagc tggctgatat ccgcaatgtg gacaatcagg ggattatcgc 3418141 tcggccgccc tttcgcctca tatatttttt tgacggcatc cgtatttttt gcgtttgcgc 3418201 ctaggccata tactgtttct gtcggaaagg caacgacctc attttctcgg agcaaagcgg 3418261 ctgcttgtgc aatttgtgga tcatttgtgg ataactcgtc agttacatcc acaaaccatc 3418321 ttttcgtttt catttctgac caaactcctt attcacaaca ataaaacgat tgttttacgc 3418381 gtgtaatcct tttgaaagta taaaagatgt cctgtaataa aacaagcgtt atccacaaat 3418441 tgtggacaac gctaataaag aagtggataa gtatgtgtat aaactgcact tatccagacg 3418501 cttttttcat caaaacggct ccttctgttt gccgcgattc acagaagtga tcagaagaaa 3418561 acagctcctc cggtacactc tcagctcttt caaaacccat ggccgtcaga aagtccgcag 3418621 aggaatgctg atttgctact aggtacacgg ttttgatctg atgcttttcg cacagcacct 3418681 ccatgctttg aaaaagcgtg acgatgtggc cttggtgaag cttgtccgat atgacaagtg 3418741 atcgcagcag cccctggtca cagcttattt tttcaatacc gaggcatccg gcaatgtttt 3418801 tctcactgtc ctccagcata agaaattgag tgaagccttc tttcacgcct tcatagctgg 3418861 tttttgcctg ttttaaaaat gcctcgagca catctccgtc tttttccctt gccacccgca 3418921 gttgataaaa catccgttca ccccgttttt gcgttctttc ttccaatcta tgaggcaaat 3418981 ctatttttag accagatgat taggaaaaaa ggtcggaaat ccattcgact aaaaagaatt 3419041 tcacttctgt gccgtcttct ttttcttcgt tctcttcttt tttggctttt tccgctttag 3419101 cggttacgtc ctcaagcact ttttcagtct gcttttttga ggcttcttta tcttcttgtt 3419161 ctttgacggc ttccccgtta gaaaaatcaa gaaagcagag gggcgggaac agcacacacc 3419221 accagttggc gccgtctccg tttccaagcg taatcaaaat cgcttcatac tcaccagcgg 3419281 gatataccat gttgccgtaa agctttgtcg gaaacgagat tttgtcaaaa tcaacggata 3419341 tcgactgatt cgctccttct ttctccattg tttcctttgc aattgctttg atttcaggca 3419401 gctttgaacg aatcacgcga cgcgcttctt caatagaagt aatatccttt acccaagttg 3419461 tgatttcttt attcaccgcg tctcttatat gacgttttaa ttgctggtct tgatcactat 3419521 cgctgtttgc cagtattctc aaacgaatcg cctgatcagg tatgaccacc ggctgatttt 3419581 ccgatttttg tgccgtctct tcttttgcca gccctacgag cgctccggat aataaaagaa 3419641 agatatatat acaaatgatt actgtttttt tcatcggtcc ccaccgttcc tctccgtgct 3419701 ttgtttctag ccctattatg gacaaggaga gcctgggata aacgtgcagg gtgaaaaaaa 3419761 tctagcaagc tgttaatctt atttatggta cgatagtgtt ttaggaggtt taagatgaaa 3419821 tacaattata cagtgctgtt atcagcattc acgatgtccg ttctttattc agtaatttat 3419881 attcattcat ttatcattgc cgctctcatc acaatggcat tttattttct gtttccttat 3419941 ttgatcttcg cactgccgct tcaaatcatg atgaataaaa agccgaaacg tttcagccct 3420001 ttgtatctgc tgtattacct tgccgctgct tttattgcca acgcgatcat tttcggcatg 3420061 cttcagcctt cgggacaatc tctgtttcaa aatacagcct tttatctttt cgctgtatta 3420121 acagctctta tctattggat atgggattct gttttactgc aaaaaaagga agcctaagag 3420181 gcttcctttt ttattaaaac aaaatcgtca gtaaataaca tagaatggaa ggtatcgccg 3420241 caacaaagaa agcggccgcc attttcatgc gagatgtacg gccttctttg gtttctgaat 3420301 ggtagtttgc ccgctgatcg cttccgctta cagccaaacc cgatgtaatg atcgcgagcc 3420361 ccactaaaac gagagacgca acgccaaaaa tcgcttcata tgaaagagcc tgcggaaaaa 3420421 tggtgccaat catgctctca atcgcaatga gcaggattcc tgctgtcagg gcctttttca 3420481 tgtttacatc ccctttgctg gtgttaaaca gcttgatcca ttcactcgcc agcaagctgc 3420541 ttatttattt ttatgaatca gagcgcatat ggttctgtct tttccattaa tatctttcag 3420601 cacttccact tccgccccct taaacgcctt gaggatcagg tctttgaccg ccgctccctg 3420661 tttccagccg atttcaaaaa cgacaaatac tttatccttc ataacaagcg gaatgtcttc 3420721 cataaaccgc ttataaaatt tcagcccgtc tccgccatcg gtgagtgcgt gcagcggctc 3420781 atgaaaacgg acaatttccg ataaatcagc catttcttcc tctgaaatat atggcgggtt 3420841 tgagacaatg atatccgctt tttttcccgc cttaataaaa ggctcaagca gatcgccctg 3420901 ataaaagcgc acattcgctc cgagtttttc tgcattggca gaggcgactt gcagcgcctc 3420961 tttcgaaata tcgaccgccg acacagaaaa gctttggttt tcaagcgcaa gcgtgacggc 3421021 tattgcgccg ctccctgtac caacgtcaac aacttcgagc ttgccgtctt cagaaaaaac 3421081 actccgatat ttttcaagca aatgaaagac aacttcttca gtttccggcc gcgggatcag 3421141 cacatcatca ttcaccataa attcccgtcc ataaaaaaac tcttttccta taatgtattg 3421201 aaccggcacg ccctctttat gcatctcaac gtgacgctta aagcgataca gttcgtcttc 3421261 accaatcggt tcctgtaagc ttgcgagcag cttgcttctc tccattccgg tatcataaag 3421321 caataggagc tcggccgcat tttcttctct tcccgcttcg gttaaataag aagaagccca 3421381 tttcagggct tcgaatatcg tcttcatctt aaccttccga ctgctgaagc ttgcttgcct 3421441 gatcttcaac aatcagcgct tcaaccactt cgtcaagttt tccttcaaga atctgatcaa 3421501 gcttttgaat cgtcaaaccg attctgtgat ccgtcacacg gttttgcggg aagttgtatg 3421561 tgcggatacg ttcagagcgg tcaccagatc cgactgctga tttccgtgtt tgatcatatt 3421621 cagcctgggc ttcctgctga aatttatcat agattctggc acggagaacc ttcattgctt 3421681 tttctttgtt cttaatttga gatttttcat cctggcatga tacaacaaca cctgtcggca 3421741 agtgagtcag acgaaccgca gacattgttg tgttaacgct ttgtccgccc ggtccgcttg 3421801 aagcaaatgt atcgacacgg atatccttct catggatgtc gacctctacc tcttctgcct 3421861 caggaagaca tgccactgtt gcagtggatg tatggatgcg tccgcctgat tctgtttccg 3421921 gaacacgctg tacgcggtgg gcgccgtttt catatttgag tttagaatac gcgccgcttc 3421981 ctgtaatcat aaagatgatc tctttgtagc cgcccgttcc ggttacattc gcttccatga 3422041 cctctgtttt ccagccctga agctcagcat aacgggaata cattctgtac agattgcccg 3422101 cgaataaagc ggcttcctcg cctcccgcag ccccgcggat ctccatgata acgtttttgt 3422161 cgtcattagg atctttcggg atcaggagca ccttcagccg ttctgacagt gtttccgttt 3422221 ccttctgaag ttcagaaatc tcttccttca ccatgtcgcg catctcagca tccagcttct 3422281 cttcaagcat cgcttttgca tcagccagct gttctgacgc atctctgtat tgtctatata 3422341 cgtcaactgt ttcttgtata tcagattgct cttttgaata ttctcttagc tttttcggat 3422401 cgttgactac ttctggatcg ctcaaaagct catttaattt ctcgtatcgt tcttcaattg 3422461 attttaaacg gtctaacacg gtcttcacct ctgttttcct gtgcgtaaca ttctcattat 3422521 agtatagtga ttaaccccag tcaaaagcat ttcaatccca gctggaaaag ctccctctgc 3422581 tatactggaa ttcgaggagg gatgatgttg ctgaaatcca tacatcatat tgcaatcata 3422641 tgttcagatt acgaaaagtc gaaagctttc tacgtacata agcttggttt tcaggtgatt 3422701 caagaaacgt accgcgaaga gcgcggctcc tataagcttg atttgtcgct taacggctcg 3422761 tatgtcattg agctgttctc gtttcccgat ccgcccgaac gacaaacccg gcctgaagcc 3422821 gcaggcctgc gccacctcgc ctttacagtc ggcagcttgg ataaagctgt tcaagagctt 3422881 catgaaaaag gaatcgaaac agagccaatc agaacagatc cgctgaccgg caagcgtttc 3422941 accttctttt ttgatcctga ccagcttcca ttagaactgt atgaacaata acagtttttg 3423001 aagaaaaaaa ggagataccc actttctttg ccgaatcttt tcttgttttg tctaacggga 3423061 agggaaccgc attctatggt cgaataccta gcttaaaagg aggtatggga tcatgaatac 3423121 aaatatggta gcaagtgaac tcggcgtctc cgcaaagacg gtgcagcggt gggtgaagca 3423181 gctgaatctt ccggccgaac gcaatgagct cggacactat tcgttcacgg cagaagacgt 3423241 gaaggttcta aaatccgttc aaaaacaaat ctctgaaggc acggcgattc aggatattca 3423301 tctgccgaaa agcgctaaaa agcgcacagg cttccttgtc caaaaaacaa gtagcgacac 3423361 agaacgaaga atcgagcagc ttgaacaaaa gctggacacc cttttacagc aaaggcagga 3423421 cgaaagcgaa ttgatggcaa ggatgtcgga actggaacgc cagctgaaac aaaaagccga 3423481 tgaaggtgta tcttaccagc tgcttcagca ccgcagagaa atcgatgata ttcttgcaga 3423541 tctgcaatca ctgacctcac aaatgaaaga attcaccgct cattcgatcc ccgagactgc 3423601 tgctgcttct gaaaaaacca aaacaagaaa aaaaccgctg ctgtcactgt tcaaatttca 3423661 aacctaaagc aaaaagctcc cttaaaggga gctttttttg ttacgcagta agcgcgataa 3423721 tgattggaag tgaaatcaat gacagaatcg cactgaccac aaacgcagtt gcagtttctt 3423781 cttcttgttt ctcgaaacga gtcgcaatca tggctgcaac ggcagaacca gggaatgcaa 3423841 caagaaggat tgcttttgtt gtttggtcag ctggaagtcc gatagcaaga gcaatcagga 3423901 acattaacgc aggctgaacc gcaactttta gtaacgcaat accgatagcc ggcatactga 3423961 gtttaatttt acgaatacca acggtaacac caacagcgaa gagagcaaca ccagatgttg 3424021 tgcttccaag ctgatcaagc attttaacac ccagctcagg aagagtgaaa ttgaaaacca 3424081 gcaccaagat catactgatt aacggagcag ctgcaagcgg ctcacaaaga ccatgcagga 3424141 ttgattttcc tgtcatcttc cagaagctgt cgccactctc ttcgtttttc ttagaagact 3424201 caccaacagt agcgataatg atcgcgagcg gatcaagaat cgcgttaacc acgatacctg 3424261 tgaccgcgat cggaatcgca acttcattcg ctccgaataa gcttcccaat accgggatac 3424321 ccataaatgc gaatgtcggc tgtgcagagt tcaaagaaaa tacagatgag ttcgttaaat 3424381 catacttgaa tataaatctg caaaccaaaa gaatgatgat atagaaacca acaatcccaa 3424441 taattaaaga aatcattaaa ggtacttgtg ataaaaattc acttctggaa gttgtcaaaa 3424501 taccagcgat aaagtgagct ggaagtgcgt atttcgttac taacgtactt accccttttg 3424561 ccgacttggc atcataactt ccaaaatgtc ctgcaaacca acccagcacg ataacaaaga 3424621 agatcggcgc caggaggatt aagatatcta agatgctcaa aatattctcc tccaaatcct 3424681 atgtccgtat actttagctt tacaaaaagc tttccctcgg acagaaaaat ttactcgcta 3424741 attatttcgc gatgactttt ttgtattcag gtgtccacat tgcatcaagt accgcttgtt 3424801 tcacatcttc aggctgacga tttgccacgc cgtctttaat tgctgcttca gcaacggcaa 3424861 tcgcaacttg gatagaaacc tcttgaagct tatcaatgct tggaagcaat cctgctccag 3424921 gtgtttcaag atcaaccatt tcagcaatcg catcagcagt tgcagcaaac atagcaggtg 3424981 taatgatacg cgcttcagct acaattgaac caagtccaag accagggaac gcgaatgcgt 3425041 tgttagattg tccgatttca taagaaacac cgttgtattc tacattgtca aatgggcttc 3425101 ctgttgcaat aagcactttt ccgtcagtcc atttgaacag atcttcagga acagcttcag 3425161 caaggtgagt cgggttagac atcggcatga taaccggacg gtctacgtga gatgccattt 3425221 cttttacaat ttcctctgtg aatgcacctg aaacccctga agtaccaatc aagattgttg 3425281 gtttcgcttg acgaacaact tcatcgaatg gaatttgacc tttttcatcg cgcttccagt 3425341 ctttcacttc atccgcattg cgaaggtaag gtttttggaa atcaaggatg ccttcgatgt 3425401 cttcagtcag caagcctctg taatcaagtg tgtagaaacg tttgttagct tcttcttcag 3425461 ataatccggc tagcaccatt gtgtcacgga tttggtcagc aataccgata ccagcagaac 3425521 cagcaccgaa gataacaaca cgctgatctt taatagaagc gccggttttc ttcatagcgg 3425581 caagcacacc tgcaagtgta atcgcgccag taccttgaat atcatcatta aatgtcagga 3425641 tttcatgatt gtattttttc atgatgttgc gtgcattttt gttgccaagg tcttcccagt 3425701 gaagaagcgc tttagggaag aatttcaatg cagcttttac ataagcgtca atgaaagctt 3425761 cgtagcgttc accttgaaca cgttcatgct tgttaccaat atataaagga tcgtttagaa 3425821 gtttttcgtt gttcgtaccg acatcaagca caaccgggat aacacggcta gggtcaatac 3425881 cagctgcagc agtgtagaca gccaatttac cgattgcaat attaataccg cctacacccc 3425941 agtcaccgat accgagaatg ctttcggagt cagtagcaac gataagatca atatcgcctg 3426001 ctgtcgcatg aaggttttca aacgcttttt caataccgtc aatgttatcg attgacaagt 3426061 agattccttg aggtcttcta tattcatggc tgtattcctg aatcgcttca ccaactgttg 3426121 gcgtgtacac aacaggaagc atttcgcgaa gatggttttt cagcaattta tagaaaagaa 3426181 cttcgttacg gtttgcaaga tcacttaagt aaacattttg acgaaggcgg tcaggctgcg 3426241 cttggaattg ctcgtacgcg cgttgtgctt gttgatcaag agaaagtaca gttggcggca 3426301 gaagcccttc taagccgagt tcttgtcttt cttctagtga aaaagcaacg cctttattta 3426361 aagtaggaat agataaaact tcttttcctc taagagttgt ttctaagtgg ccttctttcg 3426421 ttttttttat gttattcaag caaatctcct tctttcttga aatagttaac caagttaagt 3426481 aataacccat ctaaaatatg accgatcatg atctttatgc gactttgtga caattattcg 3426541 aacaatgtct caaaactatt tacattacgt aagctattgt atgcctgtca aaatcaaaat 3426601 tcaagagaag aaaattactt aattttttaa tatacttatt taaatttttt aattgaatat 3426661 tatcagaata taaaaaaaac accggtgttt ttagccggtg cattctatct ttatacccat 3426721 gttttggact attttttaga tttacctggg acttcgtgat gatgtctgca tcttgcttca 3426781 tatgattcag ctgcaccaac caaaatgacc ggatcatcgt aagaagcagg tttgccgtca 3426841 atgaggcgct gtgttctgct cgccggtgat ccgcaaacag aacagacggc ttgcagcttt 3426901 gtcacacttt ccgcaatcgc catgatattc gggacgacac cgaacggctc tcccctaaaa 3426961 tccatatcaa ggcctgctgc tatcacacgg tagcctttat cggcaagaga tgataaaacc 3427021 tcaacaattt cctgatcaaa aaactgcact tcatcaaccg caaccacatc tgtactttca 3427081 ctgatgtgat cccaaatgtc cgcagcagac gaaatggcat agctcgtcat cgatgttcca 3427141 ttatgggaga caacagcagc ttcgctgtat cggttatcaa ttacaggctt aaataccctg 3427201 acttcctgct tggcataagt tgctctcttc actcttctga tcagctcttc agatttcccc 3427261 gagaacatgc tgccgcaaat cagctcaagc cacccgcttt gtttcattat gtacataggc 3427321 ttcgctcccc tctctctgcc agctgtgttt tagacaatat aaaaaacagg caagactgct 3427381 gcttgcctgt tgagaaatct attattactt aagaccgtat tttttgttaa agcgatcaac 3427441 acgaccatca gcagaagcga atttttgacg gccagtgtag aatgggtggc attcagagca 3427501 aatctcaacg cgtacctctt cttttactga gcctgtttca aattcatttc cgcaagcgca 3427561 tttaactgtt gcttttttga aattaggatg aattcctgct ttcattgtat ccatctcctt 3427621 ccgccctgaa tcccgtgtgg aaacagagtt attatttcgg agcattgtcc gaaacgcata 3427681 tgagaaaatt atatcagtga tttacttctt ttgcaaatac aatttacctt cttgcagatg 3427741 atagatttgc ctgtttccat tcttgattga gaatatcgaa aaattcctgg tttgttttgg 3427801 tttttttcat ttttctcatg aacttttctg cgaaatcagg tgaatcagac atcgttttgc 3427861 ggatagacca taaacgatca agatgctctt taggcacaag cagctcttct ttgcgcgttc 3427921 ctgaacggcg gatatcgatg gcagggaaga tgcggcgctc ggcaagagag cggtcaagat 3427981 ggagctccat gttgcctgtt cccttgaatt cttcataaat gacatcatcc atacgtgaac 3428041 ctgtatcgac cagagccgta gcaaggatgg ttaagctgcc gccctcttcg atatttctcg 3428101 cagccccaaa gaagcgtttc ggacggtgga acgccgctgg gtcaatcccc ccggaaagcg 3428161 ttcttccact tggcggaatc actaagttgt aggcgcgggc aagacgtgtg atgctgtcca 3428221 tcaggataat gacgtctttt ttgtgttcca cgagacgcat cgcacgttca agcacaagct 3428281 cggccacttt gatatggttt tccggcactt catcaaacgt tgagctgacg acatccccag 3428341 ctacagagcg ctcgatatcg gttacttcct caggtctttc gtcaattaaa agcacgatca 3428401 gctctgcttc aggctggttc gctgtaatgc tgttggcaat ttccttcagc aacatcgttt 3428461 ttccggcttt cggcggcgca acaatcaatc cgcgctgccc aaatccaacc ggcgccatca 3428521 tgtccataat tcttgtagac aagaagttcg gctttgtttc aagcaccatt tgacgatccg 3428581 gataaagtgg cgtaagagcc gggaaatgca cacgctcttt tgcagattcg ggatcatccc 3428641 catttactgc ttcaacgtgc aaaagtccat agtaacgctc attttctttt ggcgggcgaa 3428701 ccttgccaga tactttgtct ccgttccgca aatcgaaacg gcggatttgt gaagctgaga 3428761 tgtaaatgtc ttctgagctt ggagagtagt tgatcggtct caggaatccg aaaccttcag 3428821 actggatgat ctcgagaacg ccttccataa acagcagatc ttcctgttct gcattcgctt 3428881 tcagaatggc gaaaatgagt tctttttttg tcagtttgct gtaataggag attttataat 3428941 gtcttgcaag ttcataaagc tctttcaatt tcatattttc caaagaggaa atagatacgt 3429001 ctttcataaa aacaccacgc ttttcatagt caatatctta ctctgaacat gtcatctgct 3429061 gcttttgcac aacatccgcc aaagcacatt ctttttttaa cataaaggaa cttctatcgg 3429121 taacacttcc acccatgatc ggcgcttttg ttaaaaggat tgtcttaatg agttttgaag 3429181 gaagcgagga caaaaacatg agaagatcaa tacttatatc gtctgtatgc ggtagaaatt 3429241 gaaactttcc tagtgcttaa aagaaggtat tacgcagtaa aattcgcagc actctttatt 3429301 tttaccttat ttcaaaaaat tattcaactg aaataaggtt ttgacacgga attgatagag 3429361 ttgacgcttt tctgcaaaag ttaaagcggg ctcacacccg ctttttctgt ttgttatgga 3429421 cggattacaa gatttggttt ctttttcaag ctgtgtctgc cgtcaacgaa acgaacagtg 3429481 cccgattttg cacggataac taagctttca gttgtaccga cagagccttt gaattgaact 3429541 ccttttaaca gctcgccgtc agtaacccct gtagctgcaa aaatcgcgtc atcacccttc 3429601 acaaggtctt ccatgcgaag cactttgctt aaatcaaggc ccattttgtg acagcgagtg 3429661 atttcttctt cgctttgcgg aagaagttta ccaatgattt ctccgccgag tgcttttagc 3429721 gcaacagcgg aaagcacacc ctcaggagcg ccgcctgatc cgaacaggat atcaacgccc 3429781 gtgtggtcga aagccgtgtt gatggcgcct gcgacatcgc cgtcattgat caatttgatt 3429841 ctggcgccgg cctcacgaag ctcggaaatg atttttgcgt gtctttcacg gtttaaaatt 3429901 gtggcaacga cgtcctcaac gtccttgttt ttcgcttttg ccaccgcttt aaggttgtca 3429961 atgacaggtg cttcgatgtc aatgcagccc accgcttccg gaccgactgc gattttttgc 3430021 atatacatgt caggagcatt cagaagcgtg ccatggtctg cgaccgcgat aaccgtcagc 3430081 gcgttccagc cgccgcttgc taagatgttt gtgccttcaa gagggtcaac tgcgacatca 3430141 acgcgagggc cgtacccgtt tccgagtttt tccccgatat acagcattgg cgcttcgtcc 3430201 atttcccctt caccgattac aacggtccct ttcatcggca ctgtatcaaa aacgtctctc 3430261 attgcacttg ttgccgcttc atcagcctca tctttttttc cccggcccat ccatcttgct 3430321 gatgccaatg ccgcagcttc tgtcacacgt accaattcca ttgataaact tctttccatt 3430381 tcaacacgat ctcctctcac aagaaaccat tatgaatttt gaagctgttc tatttcttcg 3430441 tcagtcattc tttcacgcca aattgtcgct ccaagcccct caagcttctt ctcaaggctg 3430501 ctgtatcctc ggtcaatatg ctccagtccc gtaatttccg tgacgccatc agccatcagt 3430561 ccggctacca ccaagcaggc tccggcacgc agatcactcg ccttcacttt tgcgccttga 3430621 agctcgacag gacctgtgat gatggcagat ctgccttcta ctttcatatt ggcacccatt 3430681 cgtctcagct catcaatgtg cttgaatctt gccgagtaga tggtgtctgt gacgacactc 3430741 gtccctttcg cccttgtcag gagcgccgtc atcggctgct gtaaatcagt cggaaacccc 3430801 gggtatacga gggttttgac gtcaaccggc tttaagttct tctgcccgcc gacaatgagg 3430861 agctggtcgt cgcttgtttc gatatgatag cccatttctc tcagctttgc cgttaacgac 3430921 tcaagatgag tagggatgac gttatcgata atgacttcct tgcccattgc agcccctgca 3430981 atcataaatg tcccggcttc aattctgtcc ggaatgatcg tatgcttgca gccgtgcagt 3431041 tccttcacgc cgtcgattcg aatcacattg gtgcccgcac ctttgatttt ggcgcccatg 3431101 ctggtaagca atgtcgcgac gtcaatgatc tcaggctcct tggcagcgtt ttcgatgatc 3431161 gttttccctt ctgccaaaac agcggcgagc ataatgttaa tcgttgcccc aacgcttacg 3431221 acatctaaat aaatccgtgc gcctctcagc ctttcagctc gcaaataaat ggcgccttgt 3431281 tcattggtta cttcagctcc gagtgcttca aagcctttga tatgctgatc aatcggacgg 3431341 ggccctaagt gacagccgcc aggcaatcca atgaccgcct gcttgaagcg gccgagcatc 3431401 gcccccatta aataatatga cgcgcgaagc ttttttactt tcccgttagg aagcggcatg 3431461 ctgatcatcg acgtagggtc aacaaccatt tccccattct caaaatgcac gttgccgccg 3431521 atttccttta acaggtcacg cagcgtttca atatctgaaa tctctggaag cccttcaatt 3431581 gtcacctcgg aatttgccaa aatggttgca ggtattaacg caacagcgct gtttttagcg 3431641 ccgctgatat gtactgtacc gtttaacgag tcaccgccgg caatattcaa cttttccatg 3431701 atagtctcct tccataagaa gatagctgcg gagctaaata aaatgtcatt ttattctgtc 3431761 tctgcaaata aagctcatgt ccaaaatcta gccaattcga agagaaagaa tacaacacat 3431821 tgtaaaatat caggaagaaa atagcgaagc tttggggggt acaggtttca aaagatgcac 3431881 agagacccgc cggctcgaga gacatcgtcg tcatccggca aaagcagtac gcataccctt 3431941 cattccgata tcagcttctg cagcccaatg attccttctc tgtaaagcgg cgtcagcatc 3432001 tgaagatccg ctgtatcagg tcggtgaaat acaaaggccg cggcaaacag gcataaagct 3432061 gtttgccgcc cctttcatta tttgttccag tctgccagga attgttcgat tcctttgtct 3432121 gttaacgggt gtttagtgag cgcatgaatg actttcagcg gcattgtgcc gatatgagcc 3432181 cctctaagag cagcttctgt cacgtgctgc ggatggcgga ttgacgctgc aatgatttgc 3432241 gtgtcaaggc cgtgaatgtc aaaaatctgt ttaacttctg aaatcaggtc aagcccgttg 3432301 tggccgatgt catctaaacg tcccaggaat ggagatacat atgttgcccc cgctctggca 3432361 gcaagaagcg cctggttggc attgaagatc aatgtaacgt ttgttttgat gcctaagtca 3432421 gtaagtgctc ttaccgcttt taaaccgtca gacgtcattg ggattttcac cgtaatgttc 3432481 ggagcgatct tcgccagttc ttttccttcc tcgatcattt cctcagcttt caaagaaata 3432541 acctctgcgc ttacagaccc tttcacgacg tctgtgatct cgcgaagacg gtcgtggaat 3432601 gatacgttag cttcctttgc tactaaacta ggattcgtcg ttacaccggc gagaattcct 3432661 aattcattcg cttctctaat ttcatcgata ttggctgtat caacaaagaa taacattttc 3432721 aaaaagcctc cctgattaag aaattttctg aactgcgaat atgattgcgc tttctaaaga 3432781 tagacggaaa accgcctgtc aagctgtcag gcggctataa aaagttccaa ttgaattaag 3432841 cttggtttga agaaccaaat tcacgcattt taccgataac tgtttctttg atcgcttcac 3432901 gagctggtcc aaggtattta cgtggatcgt actcgtcagg cttagctgcc aatgtttcgc 3432961 gaacagcttt tgcagaagaa atttggtttt cagtattcac gttgatttta gctgtaccaa 3433021 gtgaaattga ttttttgatg tcagcagtcg gaattccagt accgccgtga agaactagcg 3433081 gaaggccagt tgattttccg atctcttcca tttctttgaa gccaaggttt ggctcacctt 3433141 tgtaagggcc gtgaacagaa cctaatgcag gtgcaaggca gtcgatgcca gtgcgctcaa 3433201 caagctcttg gcactcttta ggatcagcgt agattacgcc ttcagcgata acgtcatctt 3433261 cttgtccgcc tactgttcca agctcagctt ctacagatac tccgtggaaa tgagcaagct 3433321 caacaacttt agcagttgtt gctacgtttt cttcaaatgg atggtgagaa gcgtcgatca 3433381 ttacagatgt gaaacctgca tgaatcgctt tcgcacaaga ttcaaagctt gaaccgtggt 3433441 ctaagtgaat cgcaacagga actgtcactt tgtactcttc cataagtgct tttaccatag 3433501 caacgactgt tttgaagccg cccatgtagc gtcccgcacc ttcggaaaca ccaaggatca 3433561 ctggagattt ttcttcttca gctgcttgta aaatcgcttg agtaaactca aggttgttta 3433621 agttaaattg tcctacagcg tacccttttt ctttagctgt attcaacatt tccgtcatag 3433681 aaactaaagg catgtcgaat gtcctcctta tgtagcctga ttgtcttcta gcgaaaaaag 3433741 ctttccaccc tagcatgacc catatattgc tgtcatatgt aaatactcag atcgcttttt 3433801 ctccataact aggataccaa cttttcgaca aatcggcaac ataatgacat gattcatttg 3433861 tttcttcttt ttgtcagtta gacttcaggg gcagatattt tttgacggcg tctctgattt 3433921 cgtcgatgtc aaacggcttg gcaaagtgcg tcagagcgcc caattccttc gattcctgga 3433981 tcatgtcgag ctctccgtat gccgtcatga taatgacccg gatgttttcg tcaatgacct 3434041 tcatccgttt taagatttcg attccgtcca tgccgggaat tttcatgtcc aacagcacaa 3434101 ggtcgggccg ttcttttgtc acaatgtcaa gcgcctgcag gccgttcgca gcctgaaacg 3434161 tctggtagcc ttctttattg aacacttcat ttagcaaaat acgaatgccg tattgatcat 3434221 caacgattaa aattttttca ttcatcattt tacaccccaa tattatgatt ttcgtcaaaa 3434281 gtaagcagta ttgtatgtat tctgtttgat tttcctattt cctttaatta taatagtcta 3434341 ctttacgaca ttttctgagc attttctctt ttgttgtata ctgatattgt acgttataaa 3434401 ggaggattca cttatgttga aaatattcac gacgcagtta acaggtattt tttcccgcat 3434461 tcaggataag gaatctgacg cgattgaaga tggggcgcgg ctgcttgctc aagcggtgat 3434521 cagcgggcat tccatttatt tatacggagc gaatgagctt cagggcgtct tttatgaggc 3434581 caccgaaagc aaagaaccct tcccatctgt caaagccttt ccagaaaacg ctgaggaagt 3434641 gacagaaagc gacagggtgc tgatgttttg ctcagggacg ggcacagccg aagaacagga 3434701 gctcgcaaaa gagctttatg aaaaaggtgc gggagtcgta tgcgtatcgc ccgcagccaa 3434761 agacagtgcg ggaatagaac agtattgtga tgtgcatatt gattctaaat taaaaatgcc 3434821 gcttgttccc gatgaagacg gcacccgtta cgggtttccc tctttaatga cagcactgta 3434881 tgtctatcac gctttatcgt ttacactaaa agaaattctg caagagtatg cataatatct 3434941 tattgtacat gctggaactt gccggaaaca aataaaaaag acttgcccgc ttttgacaaa 3435001 cggcaagtct tttttattac ttctgatttg cagcttcgac agacgctccg ataaagcctt 3435061 tgaatagagg ctgaggtctt gtcggtcttg acttgaactc tgggtggaac tgagaagcca 3435121 cgaaccaagg gtggtctttc agctcgatga tttcaacaag gcgtccatca gggcttgtgc 3435181 ctgagaatac gaagccttgc tcttccattt gctgtctgaa ttcattgtta aactcatagc 3435241 ggtggcggtg gcgctcgtac accacttcat cctgatacac ttcaaaggct ttcgtgcctt 3435301 cttcaagctt acaagggtaa aggccgagac gaagcgttcc cccaagatcc tcaacatcct 3435361 tttgttcagg aagaagatca atgatcgggt attgagttga cggatcaatt tccgctgagt 3435421 gagcgccttt taagcccaat acgtttcgtg cgtattcaat agacgccacc tgcatgccca 3435481 agcaaatgcc caagaacgga atgttgtttt cgcgcgcgta ttttgtcgcg acgattttcc 3435541 cttcaacacc gcggtctccg aatccgcccg gcacaatgat gccgtctgtt ccgcttgtga 3435601 gttctgcgat attgttttct gtcacttctt ccgcgttgat ccacttcact tttacatctg 3435661 tgtcaaacgc atagcccgca tggcggagag actcgacaac agaaatgtat gcgtcaggaa 3435721 gctcaacgta tttgccgaca aggccgattg taatcgtttg agacaggttg ctgactttgt 3435781 taacaagctc tttccactcg gacatttccg cttctttgca tgccaatttc atgtgctcgc 3435841 aaacaagctt atcaagccct tgtttttgaa gctccagcgg aatggagtaa aggttgtccg 3435901 catcttcaca ttcaataacc gcttttgtat cgatgtcgca gaaaagcgcg attttatctt 3435961 tcatatcttg agaaatcggc atttctgtac gaacgacgat gatgtttggc tgaatgccca 3436021 agctgcgcaa ttcttttacg ctgtgctgtg tcggttttgt ttttaattcg ccagcagctt 3436081 taatgtaagg cacgagcgta cagtggatgt acattacgtt ttcacggccg atgtcgctct 3436141 tcatttggcg gatcgcttca aggaatggca gtgattcgat gtctccgaca gtaccgccga 3436201 tttctgtaat gacaacatct gcgtttgtct ctttccctgc gcggtaaaca cggtctttca 3436261 attcgtttgt gatgtgcgga atgacctgta cggttcctcc aaggtaatct ccgcggcgtt 3436321 cttttttaag aactgttgaa tagattttac ctgttgtcac gttgctgaat ttattcaggt 3436381 taatgtcgat aaaacgctca tagtgaccaa ggtccaagtc tgtttcagcg ccgtcatccg 3436441 ttacgaatac ttcaccgtgc tggtacgggc tcattgttcc cgggtcaacg ttgatgtatg 3436501 gatcgaattt ttgaatcgtc acgttcagtc cgcggttttt cagcaaacgc cctaatgaag 3436561 ctgctacaat accctttcca agtgaggata caactccccc ggttacaaaa atatatttcg 3436621 tcatttcgtt tgctcctctc ttcgctctta gctacatttt taaaatgtac tattttataa 3436681 aaaatcattt agccttttaa atgatttata agaaaaatga ggggtgaaaa taagaaagct 3436741 ccctttcaat ttcttgaaag ggagcataac gtactatgtt ctctcttcgt ttttgaagag 3436801 cccaaaatac atactacata gttcgactat gaaagtcaag atcgttttga agatgaaatc 3436861 tgatactatt taatttcctc ttcttcatca tcatagtctt catcatcttc atcaataata 3436921 tcttcttcga tctcaagatc atcgtcgtct tcatcaagat cttcttcgtc aaaatcgtcg 3436981 gcttcaagat cgagttcttc ctcaacttca tccaaatcaa ggtcgtcttc gtcgatctct 3437041 tcaaactcgt caagatcaag atcttcttcg actgctttct tcgctttttt ctttttcgcc 3437101 ttgactgtcg gctgagtttc ttcatcaagc tgatcataag gataccagct gcgaagcccc 3437161 cacgtctggt cagaaagcgc caggaagcgg ccgtcaatgt ttaaatctgt ataaaattga 3437221 gcaatgcggt ctccaagctc ttcttttttc acgccgagca aagatgcgat ttcatttaaa 3437281 agctcctgaa aaggaactgg ttttttatgt tcttcaaata attcgtgagc gatttcaact 3437341 aaagccattt cctttagctc ttcctgtgaa tattgtttga tacccaaggt cggacactcc 3437401 ctttctatta cttatatgta tctgttttat caataatgaa agcgattttg tatcgttctt 3437461 atacaaacca tacctctcat tataaacaaa ataaaacaga atatgctacc cttaacagcg 3437521 ttaatttaaa taattttaca agagtgatcc gactgagaga tgttttccgt taatccgcga 3437581 gcattctgga gatgaccagt ctttgaattt cttgagtgcc ttcatagatt tgcgtgattt 3437641 ttgcatcacg catatagcgt tctaccggat aatcttttgt atagccgtag ccgccgaaaa 3437701 tctgcacggc ttcggtcgtt accttcatcg ccgtatcccc agccatcagt ttggacatgg 3437761 cggaagcttt tccatatgga aggcccgatg attctaacca tgcagcctga taggtcagta 3437821 gccttgaagc ttctatcatt gtcgccatat ccgcgagttt aaaagcgatg ccctgctgct 3437881 cggcgatcga ttttccgaat tgctttcgct cttttgcata ttgaagcgcc gcatcaagcg 3437941 ctccttgggc gatgcctaca gcttgtgcag ctatgccgtt tctgcctccg tcaagcgtct 3438001 tcatcgcgat tttgaagcct tctccttctt ctccgagacg ctttgatgcg ggcactacac 3438061 aatcttcgaa catgatttcc gttgtcggtg aagaacggat gcccagcttc ttttctttct 3438121 tgcctgtaaa aaatccttca aaatcctttt ctactataaa agcggtaacg ccttttttct 3438181 ttttctcggg atcggtgacg gcaaaaacaa tgtaaatatc agcaacgccg ccgtttgtga 3438241 taaacacttt ggaaccattt aacacatagt catcgccgat tcgttcagca gttgttttca 3438301 tgctgccggc gtcagagcca gaccctgctt cggtcaaagc gaatgcgccg attttctctc 3438361 cgagagccag ctgtgttaag tactctgtct tctgttcctc tgtcccaaag gcaaacagcg 3438421 gccagctgca aagagagata tgggcggaaa gcgtcacacc ggtggaggcg cacacttttg 3438481 acagctcttc caccgcgatg acgtaggcta aatagtcact tccaattccg ccgtaatctt 3438541 caggccatgg aattcccgtc aggcccagat ttgccatttc ccgaaacagc tcgcgatcga 3438601 agcgttcttg ttcgtcccgt tcagccgctg tcggggccac ctcatgcttc gcaaaatcgc 3438661 gcaccaattt tcgtatcatc tcatgttctt ctgataatga aaaattcatt gcttctcccc 3438721 cattttcaga tcagcgccta aaacggattg agccagaagc tcgacgacgt cgtacgtttt 3438781 gacttggtct tcggcttcct tcgcctttgt gccgtcccca agcatcgtga gacaatacgg 3438841 acagccagaa ctgatcaccg atgggttgac tgcgagcgct tgctctgtcc tggcgacgtt 3438901 aatcctgttg cctgtttctt cctccatcca cattaatccc ccgccggctc cgcagcacat 3438961 gccggtttcc cggcttctct ccatttcaac aagctgcacg cccggaatgg ctttcaaaat 3439021 ctctctcggc ggatcataga cttcattgta ccggcccaaa tagcacgaat catggaaggt 3439081 aatcgtctca tgaagcgggt gctgcggtct taattttccg tttttcacaa gctcggccag 3439141 cacttctgta tgatgataaa cctcgccttc aaatccgaaa tccggatatt cgtttttaaa 3439201 taaattgtat gcatggggat cgatcgtaac gatttttttg acatcatttt tttcaaattc 3439261 agaaatattc ttctcagcca gctcttggaa caaaaattca tttccgaggc ggcgcggcgt 3439321 gtctcctgaa tttttttctt tattgccgag aatcgcgaag gacacgcccg cgtgattgag 3439381 cagcttggca aaggaaattg cgattttctg gcttctgttg tcgtaagacc ccatggagcc 3439441 tacccagaaa aggtactcaa attcttttcc ttcttttttc atttctttta cagtcggaat 3439501 ctcagcatcc ggcgcctcgt cacgccaatt ttcacgttcc ttgcggttga gtccccacgg 3439561 attcccttgc cgctcaatac ttgtcattgc gcgctgggcg tcactgtcca tttttccttc 3439621 tgtcagtacg aggtagcggc ggaggtcgat gattttatcc acgtgctcat tcatgaccgg 3439681 gcattgatcc tcacagttcc ggcaagtggt gcatgcccaa atttcttcct ctgtgatgac 3439741 gtcgccgatc aagcttggat tgtaatcaag cgccgctgcg gcttcctgcg atccgctgcc 3439801 cgctgacgcc gcagccagct gattgcctct cgtatgccga aacgctgctg cgggcaccca 3439861 tggggagcgc gaggtgacgg cagcgccttt ttccgtgaga tggtctctga gacgcaaaat 3439921 caagtccatc ggagaaagca tttttccggt gcctgttgca ggacacatat tggtacagcg 3439981 gccgcactcg acacacgcgt atagatcaag cagctgagac tgtctgaaat cctcaatttt 3440041 tcccgctccg tagctttctt tcgtttcgtc ggtaaaatca attttttcaa gttttccggc 3440101 agattccatt cgattgaaaa agacgtttgc cgggccggcg attaaatggg catgctttga 3440161 ctgaggcacg tacactaaaa agctaagcaa gaataggaga tggatccacc atgcgatata 3440221 gaaaatcacc gccgcgcctg ttttcccgac accgctaagc ataaacgcaa tacctgaggc 3440281 aattggctcg ctccaagaaa gcccatgctc atgccaaatc agattcatcc cgttcccaag 3440341 cagaacggtc agcattaatc ctccgataaa aatgagaacg agtccggctt tgaaaccgcg 3440401 tttcagcctc acgagctttt cgatataacg tctgtagaat gcccacccaa cagcaattaa 3440461 aatgagaaac gtaacaattt cctgaaaaaa ggtgaaggcg ggatagaccg ggccaagcga 3440521 cagattccgg ccgggagcca gtcctttgat gataaagtca attgctccga actgaaccaa 3440581 tataaatccg tagaaaaaca tgacgtgaat gattccgctt ttcttgtcct tgagcagttt 3440641 tttctgtccg aatacattca cccatatggc gtgaagccgt tccttgaacc gttgatcaaa 3440701 ttgttctttc tggccgagct tgatgtaggc cagtctcgtt ttgaccaagt aaacaaacaa 3440761 atagacagcg taagcggtta caatcagaaa taataatgca tttgcgatga gaaagccgct 3440821 cattccaatt cccccttttt actgataaag accgcgatcc cctacccccg aatctgtata 3440881 agattatctt tatgataaat aatgaatgag tgttcagtca ataattaaat tcctgctgtt 3440941 cgggcacact acctttacta cggaaaggag tgccggtatg aaggtattta tcgtgattat 3441001 gatcattgtc gttattttct ttgccttgat tctgcttgat atcttcatgg gccgtgccgg 3441061 atacagaaaa aaggcgtacg agcctgtttt ttcaaaaaag aagagtgaca tcgaattgat 3441121 ccactgcggc gctgatctcg ttgagcggat gatgaatgat attcgccagg ccgcctcttc 3441181 tgttcacatg atgtttttta ttatgaaaaa tgatgaggtc agccacaata tgtatacctt 3441241 gctgaaaaca aaagcccaag ctggcgtatc cgtttatttg cttctggatt gggcgggctg 3441301 ccgggcaatt aaaaaaacgg cgcttcagac gatgaaaaat gccggcgtcc atgtccatgt 3441361 gatgaatcgt ccccgttttc cttttttctt ttttcacatg caaaaacgga atcaccggaa 3441421 gattacggtg atagacggaa aaatcggtta tatcggcggg tttaatatcg ccgaagaata 3441481 tcttggaaag aaggcgaagt tcggcaattg ggaggattat catctgcgca tgatcggaga 3441541 aggcgtacat gatcttcaaa cgctttttgc ttctgatcta aaacgaaata ccggaatcga 3441601 actgggttcg gatgtttggc caaagcttca gcaagggact atttctcaca agatctatgc 3441661 gaccgacggt tattcccttg aaaacatata cttggccaac attgcccaag cgaagaatcg 3441721 ccttacggtt tgcacgcctt attacattcc atcaaaaccg cttcaagagg cccttattaa 3441781 cgcaagaaaa aacggcgtat ccgtgagaat cattgtaccg atgaaatcag accatccgct 3441841 ggtacgagaa gcggctttta cgtattattc ggagctcttg gatgccggct gtcttattta 3441901 tcgttattat caagggtttt atcatgtaaa agccctcatc atagacgacc atctcagcat 3441961 tatcggaaca gccaacttcg ataaacggag cctgttctta aatgaagagg tgaatgttga 3442021 aattgatgac gaagcgttta caagtgaagt ctatgccaca attgaggagg atatgaaaaa 3442081 gtcggagctg ctgacgatgg aggatttcag caagcgcaca ttcaggcagc gcccggcgga 3442141 atggctcggc agggcattat cttatttctt ataaaggaga gttcctatga ttttcagatt 3442201 cgggttcgtt tcaaatgcga tgagcctttg ggatgcgtct cccgctaaaa cattgacatt 3442261 cgcgcgttat tcaaagcttt caaagactga aagaaaagaa gcgcttctga ctgtgacaaa 3442321 agccaatttg cgcaatacga tgagaaccct tcactatatc atcggccacg gcattccttt 3442381 gtaccgtttt tccagttcga ttgtgccgct ggctacgcat cccgacgtga tgtgggattt 3442441 tgtaacaccg tttcaaaaag agtttcggga gattggagag cttgttaaaa cccatcaact 3442501 gcgaacaagc tttcatccaa atcaattcac tctgtttacg agcccgaagg aatccgtcac 3442561 aaaaaatgcg gtaacagata tggcgtatca ctaccgcatg cttgaggcca tgggcattgc 3442621 tgatcgctcc gttatcaaca ttcatattgg cggcgcttac ggaaataaag acaccgccac 3442681 tgcacaattt catcaaaata taaaacagct gccgcaggag atcaaagagc ggatgacact 3442741 tgaaaatgat gataaaacat atacaacgga agaaacgctt caggtctgtg agcaggagga 3442801 tgttccgttt gtctttgact ttcatcattt ttacgccaat ccagacgatc acgccgacct 3442861 gaatgtagca ctgccccgca tgatcaaaac gtgggagcgg atcggccttc agccaaaggt 3442921 tcacttgtct tccccaaaat cggagcaagc gatacgcagc cacgccgatt atgttgacgc 3442981 caactttttg ctgccactgt tggaacgctt taggcaatgg ggaactaata ttgatttcat 3443041 gattgaagca aagcagaaag acaaggcgct tctccgcttg atggatgaat taagctccat 3443101 ccgcggtgtc aaacgcatcg ggggcggtgc gctgcaatgg aagtcataaa tgtgcaaaaa 3443161 taggtttacg acttgtcagc tttgggaact taggctatat aagacaacaa tcgatggagg 3443221 agaaagatca tgaaaaatat caagtctctg aaagtagccg cacaggcctt tactttaaga 3443281 aatttgattc atctttataa aatgtgccat tccggaagcc acgaggttta tatttattca 3443341 aagaaaacga tgtgcaaaat caaaagctta attgagcttg aaacgttccg catggctcat 3443401 aatgaaaagg aatatctgat cgtagttgaa ggaacaaaag catcacagct cattgaaaaa 3443461 ttccaaaatc tcatcgagcc tgctgagaga gaagcgctct aacttacata caaaaaagga 3443521 tagacatctg tctatccttt ttcttatgct cttacataat ggagctgaac cgcttgtcca 3443581 aattgttttg tcccttttaa ccgcagtttt gtttcatttg ttagttcgtg aaacagcggg 3443641 atgccgcttc ctaaaacgac gggaataaca gtgatgatga attcgtcgat ggcatcttct 3443701 ttcataaagt cattcacaag ctctgccccg ccagctatcc agatgtttga gcctttttcc 3443761 tgtttcaaac gggcagtgaa ggctctggct ccctcattga taaacgtcac atgttcatct 3443821 tgataactgt cgggcgatcc tgtaaaaaca tagcaggttt tatcctgata cgggaaaacc 3443881 ggtgttagca ctttaacgtg ctcatatgtg ctccgcccta aaatgactgt atcaacagtc 3443941 tgataaaaat cactgtagcc gttgtcacct tcaccttcaa attcatccag ccaatcgatg 3444001 cttccatctt cttttgcgat catcccgtcc aatgaaacag caatgtacag cacagttttt 3444061 ctttccatgt tctcctccta tcgatgcacc atttgcccga attgcgcttg atgcagcctg 3444121 ctgtataggc ctccggcttc gatcaggtct tgatgacggc cttgttcttc aataccgttg 3444181 tttgtgacga ctacaattct gtccgcgtct ttgattgttg ccagcctgtg ggcgatgaca 3444241 agcgtcgtgc gcccctcaga caactcttga agcgcctttt ggatcgccgc ttccgtctct 3444301 gtatcaaggg ctgaggtggc ttcgtcgaga atcaagatcg acggattttt caagaacatc 3444361 cttgcaattg acagacgctg tttttgcccg ccggaaagct tcacgccgcg ttcgccaatc 3444421 atagtatcca acccatcggg catgttatgg acgagctctt ccagatgcgc ctgcttcaca 3444481 gcttgccaaa tgtcttcttc tgatgcgcct agtcggccgt aggcgatatt ttctctaagc 3444541 gtgcccgaga ataagaaaac gtcctgctgc acgacgccaa tctgcccgcg caacgaagaa 3444601 agcgtcatgt cttttatact gatgccgtca atcgtaatgt cgccctccga tgcttcataa 3444661 aaacgcggaa gcagactgca aagcgttgat ttcccagcac ctgacggacc gacgaacgcc 3444721 accgtttccc ccgcttgaat ggataggttg atgtcattga ggacattgtg atggtcatca 3444781 tagccaaacg aaacatgttt atagcggata ttgcccttca ggccggaaac atctttcgaa 3444841 tcaggtgagt cctgaatatc cggctctgtc tccatgagct ccatatagct tttgaaaccc 3444901 gcgatccccc tcggatacat ttcgataatg gcattaattt tgtcaatagg cctgaacagc 3444961 acattcgtca agagtacaaa cgccacaaat tccccgtacg ataaggagcc gcgaatgaca 3445021 aaccacgtcc cgcacaaaag gacaaacagc gtgacaaacc gggtcagcat atagctgatt 3445081 gaaccgtttt tcgccatgat tttgtaggaa gaaagctttg tgacacgaaa acgctggttg 3445141 ttgacggcga agcgttcttt ttcaaatgct tcatttccga acgcctgcac aagccggatg 3445201 ccgccgatgt tattttctac acgcgcgctg aagtctccga tatccttgtt cagcgtggta 3445261 aatgctttgg tcattttttt gttgaaataa agcgctagcc aaatgacgat cggcataatg 3445321 ataaacgtta ataaagcaag ctgccagtta ataaacagca tcactccgaa cgccccgaga 3445381 atggtcatga ccgcaatgaa taagtcttcc ggtccgtgat gggcgacttc accgatatac 3445441 attaaatcgt tcgtgagctt cgacatcagc gttcccgtct tgttgttgtc gtaaaatttg 3445501 aacgagagct tttgcaaatg gtcaaaaagc gactttctca tatcagtctc aatattgata 3445561 ccaagcatgt gtccccagta ggtcacgata tactgaagag ccgagctgag cgcgtacacc 3445621 gcaaataacc cgattgaggt cgcgatgatc agtccccagt ccctgcccgg cagcaaggta 3445681 tcaataaaat aattgacgat caaaggaaaa ctcagctcca ttaaacctcc cgcgatcgct 3445741 gagaaaaagt cgagaaagaa caacgtttta tatggtttat aatatgaaaa aaattgccgc 3445801 agcaccctat cttcccccaa tgtataaata actgataata tttctcaatt atactataca 3445861 cgggctgttt tgtaagatca gatttctttt ttcttacaga acacctgaaa acaggcgggc 3445921 aaacgactct tttgtccggt cagccacacc tcttttataa aagccgacag ggctgagctt 3445981 ttcactttcc tgcatatcct cttcaaaatg ggcctcaagg gttcggatcg cttcggcatc 3446041 cgtgaagaac acattcactt caaagttgag ctgaaagctg cgcatgtcca tattcgcggt 3446101 accgacggag gcgagatcgc catcaatgat catgactttt tgatgcatga agcctttttg 3446161 gtaggagtac acttcaatgc cctcaaggag cagctccggg aaataggacc tcgacgcgta 3446221 ttgggtcaaa aagctgtcgt tcttctccgg caccataacc cttacctcta ccccctttgt 3446281 cgccgctgct tttagcgccg tgcgaatgga ttcattgggg acaaaatagg gcgtggcgat 3446341 ccatattgat ttctgcgctg aagaaatcat ttcataataa aggtcgctca tgctttcctt 3446401 catgtcaggg cctgtcgcga caatttgata aatgcctcct ccttccacgg gaaccggggt 3446461 attgtactcc tcttgatcaa ttagcacttc attggagaca tattcccaat ccagcataaa 3446521 gatagcgtgg agcgtttgca caatttcccc ctcaagccgc aggtgtgtat ctctccaaaa 3446581 tccgatgtac ggatctctgc tgatatattc cttcccgaca tttaatccac ccacaaaacc 3446641 ggttttccca tcgatgatca cgattttccg gtgatttctg aaattcagct tctggttgaa 3446701 aaacccgtat ttcagcggag aaaacgggac gatgtccacc cccgcttgtt tcattctcat 3446761 aatatctctt cttgccagct tcatgcttcc tgccgcatcg tataaaaacc tcacctcgac 3446821 accctggcgc gctttctcca tcataatatc catcatgccg cgtccgagca tgtctgattt 3446881 aaacatgtag tattcaatat gtatgtaaga ttccgctttt ctcattgctt tgaaaatgtc 3446941 cgggaaggtt tcttcgccgt ttttcagcac tttgatgttg cttttcgtat tgatattcat 3447001 atgggcagcc ctgatggaat atgtaaagaa cctctcttga ttgtccttca gccctgtcac 3447061 ttcgggcgtt tcctccttgt caaacagctt cctgagcttt tccctgttgt acattcgttt 3447121 tgtcttaaac agctttccct ttacataaag ctgtcccgaa aacagataaa acacgtagcc 3447181 gacgattgga aaaaagacaa gaatatggat ccatagcagc gtgtgctgcg aggtgcggtt 3447241 ttcaagaatt aatgaataga tgctgaacaa aataatgctt atatagcaaa gcaatcctcc 3447301 gtaaaactca agtctggaaa ccggaaaaaa ccaaatgaca tatgccccga tgagcatcat 3447361 atataaaaag aaaaattcca gtctcctttt cagcatcctg attctctcca atctgattca 3447421 attacctctg tattacctct tttttctaat cgataaacct tgtaagtaaa aaacctctcc 3447481 gccaaaggag gagaggttta gagaaaacta actgtcacgg aattcatccg catcgtttct 3447541 gcagaaataa agcaagacta ttggcaacgc cgagtgacaa catgagcggc aagctgaacc 3447601 cgctcagcac tccggcaagc gccgaaaaga aggcggcgct gtgactgcaa atacggtgga 3447661 tagagtaaat ttgataccca ttctgatgag agaaaatata taaaacggga aattgatcag 3447721 aaagatataa ggagttagtc aggctgaatc ataatctggc tgttccgccg gtttaaaatg 3447781 agtaaaatcc ttgatgttat ttccatatac aaacataaca ggattcccgg cagcccagcc 3447841 attaccttgg cagaaaaaac cccctcttgc aagggggatt ttcacgagcg tttccgatat 3447901 acaacgtagc tgcgggtcag atacttgagc ggcagactga acacatgaac caatctcgta 3447961 aacggccaca ggataaaaac gacgtatcct atcacaatat gaaacttaaa ccatagcggg 3448021 acactctcca tcaaagaggc gtcaggcctg aacaaaacga tttccctgaa ccagggcccg 3448081 actgtggtcc ggtaatcaaa tcctttcgaa tcaatgttga gaaacgtggc cgcaacgcct 3448141 gacagcatca tgaacagcag caggaggagc gtaaggatat cggatggcga gctcgttttg 3448201 cggattcttt tgtcaaacag ccttctgtac gtcaggatga caagtccggt acatgccgca 3448261 atgcccgccg gcaagccagc gccaatcgcc attttgtgat acatatgctc tgaaatgcca 3448321 agggaagcat acacgccttc tgggatcaga atccccatga catgcccgcc gacaacgcac 3448381 agcagtcccc agtgaaaaag tgtgctgcca gccgcaagtt ttttcttttc taacagctcg 3448441 cttgatttcg ccgtccagcc aaattggtca tgctgatagc ggtaaatatg gccgccgata 3448501 aagattgtca atacaatgta tggcataata ccccagagga tctgcccgct catgcctgaa 3448561 cagccccttc aacgctttca cgtacgccaa tgttttcaag cgcggccagc agcacgtgca 3448621 gcagttcagc gtatatactg tcattttttt cgagacggga tgccagctcc ctcacattgg 3448681 acagatattt ctcaaacacg cttctcgctg cttcaatttc tgcagccgca gcaaattcca 3448741 gcatcagcgg cagataatca ggcagctctt tctctgtcgg caggaaaccg gattgctcgt 3448801 atgtgttttt taaatgcagc aattcaatgc cgcgttccct ttgctcgcct gagttaaagt 3448861 aggtgacata catatttgtt tttttcccga agtcgaatgt atagacatag tgttcaatca 3448921 gcgcttccgg agaatagctg gctgacgtct cgaaaaagtg cagcagcttc tcccggattt 3448981 gccggttgcc gatttcttgg ataagagcct tccaatcggg aagctcggct ctccactctt 3449041 catccggata agagagaaga caggaaagag cagagaacgt gatttgccgg tctgtggtgt 3449101 tcatcttgtt acacctcatt tatcaaaagt tagaaacagg agccggggcc gcctgaaaat 3449161 gataagccgc agcttccttg ttcagcgtat aaatctgata cttcttctcg atggctgctc 3449221 ggaatcacaa agcggtcatc atatttggca atcgcaagca gccgatacat atcttcaatt 3449281 tgctgttctg ttaagccgac actggagatc agttccggat cgattgattt attcgtctgg 3449341 accgctctca tatactggcg catgacagac attttcttta atgttgaccg aatatgatcc 3449401 gtatcaccgg ctgttaacag ctgcgccaaa taatctatcg ggattctcat ttggtcgata 3449461 gccggaaaaa tatcttccgc cgtttgccgg ctgccttttc cttcaaagag attcataatc 3449521 gggctgagcg gcggaatgta ccacaccatt ggcagcgtgc ggtactcagg atgaagcggc 3449581 agcgcgatct tccagtcaat gatcatttta tagatcggtg attgctgcgc ggcctctatc 3449641 cattcagccg gaatgccttg ttcttttgcc agtttggcaa cctcaggatc attcggatca 3449701 agaaaaacgt ccaattggga atggtagaga tccttttcat tttcaacaga tgccgcttcc 3449761 tccactttgt ccgcgtcata tagcatgacg ccgaggtagc ggattctgcc aacacacgtc 3449821 tcagagcaga tggttggcag tcccgcctcc aaacgcggaa agcagagtgt gcatttttcc 3449881 gctttgttcg tttgccagtt aaaatagact tttttataag gacaggatga gacgcaatat 3449941 ctccatgaac ggcatgcgtt ttgatccaca agcacaatgc cgtcctcctc gcgtttgtac 3450001 atggcgccgg atggacagga tgagacgcat gccgggttga tgcagtgctc gcaaatacgg 3450061 ggcaaataca tcataaagac gtcatcgaat tctgttttga tcgattcctc catcttttgt 3450121 acgttgggat cttcaagtcc cgtaatgtgg ccgcctgcga gatcgtcctc ccagttcggt 3450181 ccccattcga tattcatgaa atcccccgtc aaggacgatt tcgggcgtgc taccggctgg 3450241 tgttttttct gcgggctgtt cgttaatgtt tcataatcat agttccaagg ttcatagtaa 3450301 tcatcaattg acggctgatt cggattatag aaaaggcctg caagccgatt ggttttcgag 3450361 cccgatttca gctcgagctt tccttttttc aatgtccagc cgcctttata tttgtcctgg 3450421 tcctcccatt gcttcgggta gccgatgccc ggctttgttt ctacattatt gaagtacata 3450481 tattccgcac cggaacggtt tgtccacgtg tttttgcagg tgacgctgca cgtgtggcag 3450541 ccgatgcatt tatccaagtt catgaccata ccgatttgcg ctttaatctt caagccaatc 3450601 gacctccttc agcttgcgga tgacgacgtt caggtcgcgc tgattccccg ttggaccgta 3450661 ataattaaag ccgtagctga gctgggcgta gccaccgatc atctgtgtcg gcttgacgtg 3450721 aatccttgtc gggctgttat gggtgcctcc gcggttattc gtcagctttg tgccgggcac 3450781 gttgatgtgg cggtcctggg catggtgcat aaacgccatt cctttaggaa tccgatgaga 3450841 caaaacggct ctcgcgacga caacgccgtt tcggttgaag cattcaatcc aatcgttgtc 3450901 tttgatatcc gtgtcctctg catcatcttt attcatccac acggtcggcc cgccgcggaa 3450961 cagcgtcagc atcggcagag aatcaaaata catgctgtgg acagaccatt tattatgcgg 3451021 cgtcaaataa ttgaggacga tttcttttcc ctcttgatca ggccgtttgc tcagaaacgg 3451081 gcgatgctgg aggatcggtt tgaatgtcgc catcgtttca ccgaattcca tcatcagttc 3451141 atgatcgaca taataggatt gtctgcctgt cagcgtccgc cacggaatta atttttcaac 3451201 attcgttgta aacggcgaat acctgcgccc tcctttttca gagccggtaa acgctggaga 3451261 cgtgatcacc gttttcggct gggctgtaat ttgttcgaac gtaaagcatt cttcctcgcg 3451321 ttcttccgcc aggtctttca gcttcaggtt cgtgatgttt tcaagtgatt cccatgcttt 3451381 tactgcgacc tttccattcg aagtggatga tagggttaaa atcgcttctg cagcctgctt 3451441 tgcttcactt atatttggac atccctttgc cacgctgtcc gaggtgattt ctcccagtct 3451501 ctgtttgagt gattcatatt catcggctat tgaccagctc atcccttttg ttccgctcgg 3451561 ctttaaagca acgttcggac caagtgcagt cattttatga aaaatgtgtt tgtaatcccg 3451621 ttcaacgact tggatgttcg gcatcgtttt tcccggaatg gcttcacatt cgcctttgct 3451681 ccagtcattg attttgccga atggctgggc caattcctgc atggtgtcgt ggagcagcgg 3451741 tgtcgcaacc acttctttca ccggctccat atcgacttct tctgccagat cggaaacggc 3451801 ttttgacagc gccttgaaaa tatcccagtc tgacttcgat tcccacggag ccgagatcgc 3451861 aggagcaaat ggatgaatga acggatgcat atctgtgctg ctgagatcgt gtttttcata 3451921 ccatgtcgcc gccggcagca cgatatcgga atacagcgcc gtacccgcca ttcgaaaatc 3451981 aagattgatt aataagtcga gctttccttc cggcgcctgc tcccgccatt tgatttcttc 3452041 tgggcggatg ctgtcgctgt cgtcattcat taaaccgttc gttgtcccca gcaaatgctt 3452101 gagaaaatat tcatgccctt ttcctgagct tgagatcaga tttgcccgcc atacaaagag 3452161 attccttggg aaattcactt cattgtcagg atcttcaatc gcgaatttca gttttttctc 3452221 ttggagctgt gaggccacgt acgcacctac gtcttcaggt gttgctgccc ctgctttttc 3452281 agcttcttta tacagatcga tgccattttg attgaaagtc gggtaagacg gaagccaccc 3452341 tagccgcgcc gccagcacat tgtaatcagc gtggtgcttg tagcgggatg aagcagcaat 3452401 cggtgatgcc aaatcactga tcggctggtc ctcataacgc cactgatctg tcgcaaagta 3452461 gaaaaatgag gtgccatttt gcagcttggg cacgccttcc cagtcctttg cagttgcaat 3452521 cgtctgccac ccttcagcag gtcggagctt ttcctgcccc acgtaatggg cccagcctcc 3452581 gccgtttacg ccttgggcgc ctacaagtaa aacaagattt aacactgctc ggtagatcgt 3452641 gtcggagttg aaccagtggt taatgccggc ccctacgata atcatggacc ggccgtctgt 3452701 atcgatcgca ttttgggcaa actctctggc aatcttaacg acagcttctt ttttgattcc 3452761 tgtcatttgt tcctgccagg caggcgtaaa cggctcaggg tcatcatagg agacagccga 3452821 tcgttcgccg atgccccggt tcacgccgta gttagccagt atcaagtcaa acacggtcgt 3452881 gatgtacgtt tcttcaccgt tcaggttcat ttttttaata ggaagatccc gctcgagcac 3452941 tttgtttccg tcatttgaaa aatacgggat gcgcaccgtg ccgatttcgt cctctattcc 3453001 cagcacagag agacggggtt caatcggttc cccggtttct tcatcaatca tgtgcaggtt 3453061 ccatttctgc tgcccgtccc agcgcgagcc cattgtccct tggggtatgg caaatgaact 3453121 tgtctgttca tcccaaaccg caggcttcca ctgatcatgc tttgtcttcc gcccgatgtc 3453181 cttcgcatgc agaaaccgtc ccgctgtgta tacgccattt tcttttgaca gagtgacgag 3453241 aaatggaaaa tcagtgtatt gcttcgcgta ctcaataaaa cgttcagttt cttggttcac 3453301 gtaaaattcc tgcagaataa cgtgacccat cgccatcgca agcgccccgt cagtcccttg 3453361 gcgaatactc agccagtcat ccgcgaactt tgaggattcc gcaaaatctg gactgatcga 3453421 aatgacctta gcgcctttat agcgggcctc cgccaaaaaa tgcgcgtcag gcgttctcgt 3453481 taacggaacg ttggagcccc atgtgataat atagccggaa ttgtaccaat cactgctttc 3453541 cggaacgtcc gtctggtcac cccaaatttg cggggatgct ggaggaagat ccgcatacca 3453601 gtcataaaaa ctgagcatag ggcctccgat taacgacata aaccgggagc ctgatgcgtg 3453661 gctgatcatg gacatggccg gaatcggaga aaaaccgacg tttcggtcag gcccgtattt 3453721 catcactgta tacagcagag aggctgaaat cagcttcagc acctccggcc attcagcgcg 3453781 cacaaaaccg cctttccctc tcgcctgttt ataggacttc gctttttcag ggttttcgac 3453841 gatcgatttc caggcttcca atggattttg atgcgtctgc aatgcctccc gccacaaatt 3453901 gatcagcaca ccgcgcacgt atggatattt cacacggagc gggctgtaga tataccatga 3453961 aaaactggcc ccccgcgggc agcctctcgg ttcaaaatca ggcatatccg ggcctgttga 3454021 tggataattc aaattttgcc cttcccacgt gactattccg tttttcacat aaatattcca 3454081 gctgcaagac cctgtacagt tgacgccgtg ggtggagcga acgactttgt cgtactgcca 3454141 tctgtttctg tatacattct cccaatcgcg atcctcgcgg gtagtttggc tatgtttatt 3454201 tgaatggtgt tcgataggag agaaataatt caatctccta aacaacggac tccttttctt 3454261 tttcttcatg agagttcact ccttccgagt caggtgatgc taagttcact ataaacagag 3454321 acagcgtgtt tccttgtgaa ctatgtcaca cactctgctt ttttcacaaa atgttcacac 3454381 aaaggagaag gaaggctgcg ttcaggcagg acgcttgggt cattagctgc ctttcattca 3454441 aagatcaaaa aaaaccggct ctatttaaga accgggctca gcgttttcat cctgtgatgt 3454501 atgcagatac cgcaaaaata attgatagga acaaaaaaca ttttgctgaa gcatagccaa 3454561 aaagttcatt tgcagctgcg gatgataaga catcattttc ttaaatatgt aatatgggat 3454621 gttgagaatc agaatgtctg aagtggcatt gactgagata aagggcgata aataaagccc 3454681 gcctttttca tcaatcggaa acacatcgcc tttttcccac agcgcaacgg ttttcgaccc 3454741 ttcagggagc cttgtgtcca taaaacggac actgcctttt aatacaatat aaacagattg 3454801 agaatgaaga aaagatggag actgatcaca tgaaccgcgg ataaacgtgc cgtttttcag 3454861 caaggtttcg acaatggata gaggcacttc attaaacata ggaagttgtt tcagaaataa 3454921 taaatagtca cactgattca taggaaaacc tcctgtgcta aggatagctt tagtgtagct 3454981 cgactgagcc tgtacagcag tgatgtattt cacagcctgt atgatgaatg tcacttatca 3455041 ggagggtgaa tgcatttata atgaaagaaa aaaggaggat ttcgatgaag gcgctgattc 3455101 cgaagcagca cggggcgtgg gcgatgctgc tgatcccatt tttactcggc atggtcaagg 3455161 gaggccccgt tatttggcat attccgctct tccttggttg gcttttccta tacttagcgg 3455221 tttatcccgt tacgcttgcc ttaaaaaaga aacaaagcaa accatatcaa aagtggatgt 3455281 gttattacgg ttttcccacc tgctgctttt tgatgatctc ggtctttcat aagccgcctc 3455341 tcatctgggt gggcgtttct ttactgccgc tgtttctcat acatatgtat tttgcccgca 3455401 gaaaaaacga acgagcctta ttgaatgatg ttgcaggtgt cttgttcttt tgttcgggcg 3455461 ggtttgcgag ctgctggctg gggatgggaa cccttgacgg ctgggcttgg tttattttct 3455521 tgcagtctgc tttatttttt atcgggagtt ccttttatgt gaaatcggtg atccgcgaga 3455581 gaaaaaacag ggcatttgca tactggtcat ggggatatca cctgctgctc ccctttttat 3455641 ccgctctttt cggagcagga tgggcgtttc tcgcttttat cccgagcagc ttgcgggcat 3455701 ggttttttca tggaagggat tggcccgtaa aaacgattgg cattctggaa atcgtgaatg 3455761 cctgcttctt tcttgccgtc atgtgcctgt ttatcacaag gtaaaaaaac aaggacaccg 3455821 ctgtccttgt ttttttcagt caatattgca aatctccagc gggcaatttt cacactcaat 3455881 ctcacatcgt aaatagtccc gcttgtgcaa aataattttt ccggattcgt ctatcgaaat 3455941 aacccctttt ttgcggagat ctccgagcat acgattgacg ctttcccgtg cagccgcgca 3456001 aaactttgcc aaatcctgat ttgtcaggac aatgttaatc agaatgccgt cgcttcgctc 3456061 cactccgtag ctgtttgata agcggataag ggtagaatag agcgccccct ttttgccatg 3456121 aagaagcaga tccctgattt tggactgaat cttccggagg tgcgtgctca tccatttcat 3456181 gaactcaaat gtcaaagcgc cgttttggat taattctttt tccagcttat ttttattaat 3456241 gacgagcacc tcgccatcct ctagtacttt tgcactgagc atataccttg gttcttcagt 3456301 gaaaagtgtt aattctccga cgatatcatg cttttggcag attctaagcg tcaggtcttt 3456361 tccgtcagat gtcagcttgc cgatttcaat gagtcctgat tgaatcagat aaagctcttc 3456421 tgcatccatt ccttcccgaa acaaatacgt gtgtttttcc atttttcttt tcgtgctgat 3456481 cgattccagc aattcataca gatcgctgga tataagatca ctatcagatg gtcgaacaga 3456541 gagaaaattc atgagctcac ctcgaagaaa gtcacgttgt gtgtttattg taacgtgaat 3456601 tgatttgtac ccatcgagaa aaaactaaca atcttgtgaa tgccccagtg ttagttgatg 3456661 ctctggctgt ttctctccgt gtgtgttttc attctttcct gccaatacat ccatatgaca 3456721 aggacaaaac tggctaacgc cacctctgaa agcgccataa acccgatcgc gtactggcct 3456781 gttgcctgaa atacactcgc caatatgagc ggaggaaaaa agccgcctaa accgcccatg 3456841 gcagacacaa tcccattggc aatccccgct tgcttcgaaa aatagaaagg caccagttta 3456901 aaaacagttc cgtttcctat gcctgagcag acggccacgg ttaatgatcc aaacgtataa 3456961 aggccgattg tcggcgagaa cgataggata atgcctgata atgtaagccc ggcaaaaaca 3457021 aacatcaaga tgcggagcgg gctcatttta tcagccagga atccgcccgc aggcctgagc 3457081 agcgtagaaa ccgcaataaa gccagccgtc cgcaagccgg catctgcagg attcagccca 3457141 aaatgctcca ccagaaagtt cggcagatag atagtgaagg cgacaaaggc accgaacgta 3457201 ataaaataaa acaggctcag aaaccatagc acatgatttc ggtaaacagc tttgatttga 3457261 gtcttaacag aaactttgac cttcttctca tgcctgtcgc caaacaatac gtgcagtaag 3457321 gcaaagacag ccagcaaaat cagatacatt tgcacggttg atttccaccc gacggcttga 3457381 gcgataaccg gcgctgcaaa tgtcgtaacg gctgtcccga tatttcctgc accgtaaatc 3457441 ccattgacga caccgtgctt ttctttcgga taatatttcg ggagggaggt caccccaatg 3457501 gaaaacaccg ctcccccgat ccctaagaaa aagccgcctg cgattaaatc aaacagagaa 3457561 tccgcgatac tgatccaaaa tacaggaaat aaaagcagga tgaagctgac cataaacatg 3457621 agccgcgcgc caaacctgtt cgttaaatac cctaaaggaa tgcggagaag cgacccgagg 3457681 atcacaggaa tcgcggtcac taaagaaatc tcacccttgc ttaaatgaat atctaatgtg 3457741 atttgggaaa tgagtgatga aatcagcacc caaaccataa accctgccac caagcttaat 3457801 gactgtaacg ataattgaat gtgttgacgg ttgatcattt ggcttgcccc tttcaatgat 3457861 tcaataatca gtcttatcat acaaaaacta gccaaacagg attgtgaatt acatcacacg 3457921 tttttctcat aaaaaaagga caaagcccga agactttgtc cttttgatcg tgattacatt 3457981 ttttccggag ccgatacgcc gatcagctga agcgcattgt tcagcgtaat ttgcgttgcc 3458041 ttcattaaag ccaggcgcgc gcggcttttc tcttcatttt cagggtcgat gactttctct 3458101 gcgttgtaga agctgtgcag agcagaagcc agatcataaa tatagttagt gacacggtgc 3458161 ggaattcgtt tttccgctgc ttccgccact gcctctggga agccgccgat cgttttcagc 3458221 agatcgtatt ctttttctga ttgaatatgg ctgaaatcaa gatctgccgc cggtttaagc 3458281 ccctgctctt ccccttggcg aagcatgctg caaatacggg catgcgcgta ttgtgcataa 3458341 tacacagggt tttcgttaga tgttgataca gcaagatcta agtcaaaatc catatgggtg 3458401 tctgcacttc gcattgcaaa gaagtaacgc acggcatcca agccgacttc ttcaatcagg 3458461 tcacgcatcg ttacggcttt accggtccgt ttgctcattt tcattttctc gccgtttttg 3458521 taaaggtgaa cgagctgaat gatttctact tcaagcgttc ctttttcata gcccagcgct 3458581 tcgattgccg ctttcatacg cgggatgtag ccgtggtgat cggcgcccca aacgttgatc 3458641 agcttatcaa agccgcggtc aagcttgtcc ttatgatacg cgatatcagg aagaaggtac 3458701 gtgtacgtgc cgtccttctt gatcaatacg cggtctttat catcgccgaa agtcgtggaa 3458761 cggaaccaag tcgcgccgtc ttcttcatag acgtggcctt tttcgcggag cgcttcaagc 3458821 gccttgtcga tttttccatt ttggtacagt gaagtttctg aataccacac atcaaacggc 3458881 acacggaagt tttccaagtc cttgcgaagc ttttccagct cgtatttcag gccgtattca 3458941 cggaaaaacg cgaggcgttc actttcctct tcgttaacga aacgatcacc gtattcctca 3459001 gcgagacgct ttccgatcgc aatgatatcc tcaccgcggt agccatcctc cggcatcggt 3459061 ttttccaatc cgagtgcttc aaagtaacgg acttcaacag aaagcgccag attgttgatt 3459121 tggtttcccg catcgttaat gtagtattcg cggcttacat cgtaacccgc ttttgaaagc 3459181 acgttgcaca aggaatcgcc gacagccgcc ccgcgcgcat gcccgaggtg aaggtctccc 3459241 gtcggattcg ctgatacgaa ttctacctga actcgttcac cgtttccgat gttcgtttcc 3459301 ccgtatgctt cccctgcttc cagtacagac ggaatcagct ttgttaaata ttgattgttc 3459361 atatagaaat tgataaaacc cgggccggcg atatccagtt tttcaatcga agccttccct 3459421 ttatcaaaat gggcgacaat ctcttcagcg atttgacgcg gcgctttttt tgccactctt 3459481 gccaactgca tcgccatatt cgttgagtag tcgccgtgtg ttttatcttt cggtgtttct 3459541 aaaacaacat tgggaatctg gctttcttca gccagtcccg ctttcagaac ggccgctttg 3459601 atttcttctt tcagcacgtc cttcatttgt tccgcaatgt tcatgcgtga gttcctccct 3459661 catacgtgat cgtcatatta tgtaaatgct cctgctcgtc tccgacatgc atgtcatatg 3459721 cgatgctgat acggcctttt tcttcatcga gatcagattg aatcgatttt gtgcttgttt 3459781 tcagctcaag ctcaccaaat gacattttat atttagcaat tgtggaagct cccgttacga 3459841 aacgctgatt cattttgaca gcgcctgacc tcatgaccag gacttcgcct tcgcttactt 3459901 tcacaatcgt tttgactttg cctaagtcgt gttcttcata ataagataga tacactttat 3459961 tttgttttac atagtaaaat ccggtggtgc ggaattcgat gacttcttgg tttccgtcat 3460021 cctcgatcac agacttcaca tggagtgtta tcggtgtctc ttgcttcatt ctgacacgtc 3460081 cttttcatca ttccactttg acttgaatag tataatcatt cggtttgtaa acttcaactg 3460141 cttctatctt accatcattg ctcatcagat ttgaagataa acctcataaa aagcatttcc 3460201 ttatatagaa gagaaaatca tatcactaat tacctttagg aaatgttacg agctcgctac 3460261 atcgcaatcg cagacggacc cgcgccaacc ggaatcaccg tcacggctgt ataatcactt 3460321 gtgcggtaca cggtcacagc attgtcgttg ggctgtgccg cataaatata ctgtttgtcc 3460381 ggcgttacgg cgaggtcaaa ggcgccgggg agagacacgt ttgcaatgat cctctgtctg 3460441 gccgtattaa ctacgtataa gttattaatg agaaacggtt cactatatgg ctctagaaaa 3460501 taagctctag tactatcgag agaaaataca atcgtcctca gcgtttcaaa taaacggctg 3460561 aagtcccctc ccctgcttaa tggtgacaaa ctaatctccg ttacaccttt cggccacagc 3460621 tcaccattca atacgtacgc aaaatttcca gcgtaaggag ttgtaattaa actgggaaat 3460681 tcaaatgtat ctatgatact ttctaccaac tgcccagtat ttacatcata tttatcaacc 3460741 gaccaactgc ttccattagc ggtatagaca tactgtccat tcggatcaag agcaaagtct 3460801 aaagcgccgg gtatcggaat gacatcaatg accgattgag aggccgtgtt aatcacatat 3460861 atagatccgg cggccatcac gtatgcgaac tcatctgttg gatcaaattc gatttttctc 3460921 ggccctcctc caacagtaat ggtatttatg atggttaatg ttttattatc aatcactgag 3460981 acaaggttgg tatttccatg gaggacatac gtgaatgctt tatcgaaagt aacgcctaga 3461041 ttagttggca cgtcagaaaa agggattgtt tttacaacag tgtttaaatc tgcatcaata 3461101 accgaaaccg tgctgtctcc agtattggca gtaaacacat acgattgagg gtctggtgat 3461161 ggcggtaaaa caagtgtccc ggccaccgta agcggactgc cgtagaaagg cggtacaatg 3461221 agcagatctt ccactgttat ttgactgaaa tcaggacagc ggccagactg tgctgcataa 3461281 taaacaactt gatcaatctc ttcagtatga atcacagaaa cagccccgtc tccttgtcca 3461341 tattgatttc gtacaggcga cacactgaca agaagcgtaa tggtcccttg tactctcaca 3461401 gcatatcgaa caccgatatc ttctggttcc ggcccagtct ggattaagca aggctcactg 3461461 atacaggaca aattgtctgt actccatgta acagccgctg acgcttcggc cgtatcaacc 3461521 ttgaagccct cagggaaatc tatcggcact tgaaacggcg cttcccggct aatttcctca 3461581 tcacaaaaac agaaacaatt ttcctgtaaa gcagaaagat cattcttttt catgatttca 3461641 cgtcctttta gaaatgcaca acatgcagcg gttaaatcgt aatggcaccc ggtgaaaccc 3461701 caagagatat cacagtttcc tcagaataat catctgtgtt gtaaacaatg atgctctgct 3461761 ctataaaacg agttgcatac agaaaatcgc cattcggggt aaacgcatag tctgttgctg 3461821 attgcggaac atttcctata acgcctgctc catttggact gacagaatat aaattgccag 3461881 tgaagccgtc atataaatac acctctgctc cactcgtaaa cattcgatat tccccttcat 3461941 actccagctc ttgggtgctg ctgatggtaa acgtatttaa atcaataacc gtcaaataat 3462001 taaaaaagaa ttcttgttct aatacatagg cataccgctc cggccaattt gtttctatgg 3462061 ttgatacgat aagctctcgt tcaattgttc ctgtgacttc accggtagtt aggtccactt 3462121 tttgcactat tccaaaattc agaacatagg cgaataaccc attgggatcg attgcaacat 3462181 catatccttc cacaggaatc gacctatcca cagttaacgt atcaattcca atcacataaa 3462241 ccgcagtacc ggtgaaaaca taagcaaact catgattagg gataaatcta atcaatcgag 3462301 gcggctgatc cagcaatata gttgctgtca ctgttaatgt gtcataatcg atgacagaaa 3462361 tcacattatt gttgggatgt aagacaaaca cagcgctttt atctggcgta atttcaatac 3462421 ctgccggatt gtacggaaga gcaatcgttg tcacaacagt atcggtgttt gtatcaatca 3462481 cagaaactga ttgatcattt ggattcgctg taaacgcgta gacgggttcc ggctccggta 3462541 caagcacaat tgtccccgtc accgataaag gactgccgta aaacggcgga acaacaacaa 3462601 ggttctcaat cgtgatgtca ctgatatccg ggcaatcatc cgattcatcg gaataataga 3462661 cgacttgatc gatttctgca ttgtgaatga cggaaacagc cccgtcccct tgtccatatt 3462721 gatttcggac aggtgagaca ctgacgagta gcgtaacggt tccctgcagg cgcactgcaa 3462781 attgaacacc gacctcatca ggctcaggcc ccgtttgaat taagcaacgg tcactgacac 3462841 aagaaaggct gtctgcattc cacgtcacgt ttgcaacagc ttcagccgga tcaacgacaa 3462901 acccttcagg taattcaatc ggtgcttgaa acatggcttc tcggcttgct tctccctcac 3462961 aaaaacataa gcactcttct tgttctgctc ctgctttttc tttaaaggaa agcttgtttt 3463021 ttctcattcc ttcacttcct tttcagacat acactgctca cgcagatata acagaatatg 3463081 gaagggtaac gtgtttgctt gtacaaattg ctgagggtaa acgcttcttt ttgaaaatat 3463141 atctccaaac atgcggtgta acgaaagaaa aaattgcggt ttttttgcgc ttctcacaag 3463201 aatgttgatg ataaaatatg acatatatag aattatgaag ggagggattt gcaaacgtga 3463261 caggtgtcat atcttcttct tccatcggag aaaagattaa cgaatggtat atgtacatac 3463321 gccgattcag catacccgat gcagaatatt tgcgacgaga aatcaagcaa gagctggatc 3463381 aaatggaaga agatcaagac cttcatttgt actattcact gatggagttt cggcacaacc 3463441 taatgcttga gtaccttgaa ccgttagaaa aaatgaggat tgaggaacag ccgagactgt 3463501 ctgatctgct gcttgagatt gataaaaaac aggctcgttt aactggtctg cttgagtact 3463561 attttaactt cttcagaggc atgtacgagc tggaccagcg ggaatatctg tcggctatta 3463621 aatttttcaa aaaggccgaa agcaagctga tattcgttaa ggatcggata gagaaagctg 3463681 agtttttctt taagatgtct gaatcttatt actatatgaa acaaacgtat ttttcaatgg 3463741 actatgcacg gcaagcatat gaaatataca aagaacatga agcttataat ataagattgc 3463801 tgcagtgtca ttctttattt gccaccaatt ttttagattt aaaacagtat gaggatgcca 3463861 tctcacattt tcaaaaagct tattctatgg cagaagctga aaagcagccc caattaatgg 3463921 ggagaacttt gtacaatatc gggctttgta aaaacagcca aagccaatat gaggatgcca 3463981 taccttattt caaaagagca atagctgttt ttgaagaatc aaatattctt ccttccttac 3464041 ctcaagcgta ttttttaatt acacagatcc attataaatt aggaaaaata gataaagctc 3464101 atgaatatca tagtaaggga atggcttatt cacaaaaggc cggagatgta atatatttat 3464161 cagagtttga atttttgaaa tctttatact tatcaggccc ggatgaagaa gcaattcaag 3464221 gattttttga ttttctcgaa agtaaaatgt tgtatgctga tcttgaagat ttcgctattg 3464281 atgtggcaaa atattatcat gaacgtaaaa attttcaaaa agcttctgct tattttttga 3464341 aggtggaaca agtaaggcaa cttattcaag gaggagtgag tttgtatgaa attgaagtct 3464401 aaactattac tctcttgtct ggctctaagc actgtgttcg tggcaacaac tattgcaaat 3464461 gcacctacac accaaattga agttgcacaa cgaggaatga tttaaccgcc gtccatcggc 3464521 ggttttttcg tcccctcttt accaaagtct cccaatccat gctatgatct tttcaataat 3464581 cttgaagaga gtggaaatgc agcatgtctc taaaaagtgt gagaacccac tttactcaat 3464641 ggaatcgaga aaatgatgtg acggagttcg aaacgtcgag tgcgacagtt gaacaggcag 3464701 ctgagacaat cggcgtaagc ctgtctagaa tcgccaagtc cctgtccttc agaggggaag 3464761 gagatcaggt gattctgatt gtggcagccg gcgatgccaa gatcgacaac aaaaagtcca 3464821 ggcaaacatt tggctttaaa gcaagaatgc tctctcctaa tgaggtgctg gagcagacag 3464881 gccatgaaat tggaggagtt tgcccatttg gattggctca tgatcctgag gtttatcttg 3464941 atgtatcgct gaaacggttt cagactgttt tccccgcatg cggcagcaga aactccgcta 3465001 ttgaattaac accgaaagaa ttatccgaat tttctttctc aaaagtgtgg attgatgttt 3465061 gtaaagactg ggaataaaaa aacatccaga catcgtctgg atgtttactt atttcacaaa 3465121 cccaagcagc atttcacgga tgattttgct ggctgtgttt gccgtttgct ctgagtggtc 3465181 gtataccggc gcgacttcca ctaaatcagc gccctttacg tttacctctg aacgcgcaat 3465241 ttcatggacc gatgcaagca gttctttaga cgtgatgccg ccggcgtcaa ccgttcctgt 3465301 acccggtgcg tgtgcagggt ctaatacgtc aatgtcaatt gtgacataaa ccggacggcc 3465361 cgccagcttc ggaagcacct ctttcagcgg ttcaagcact tcaaattttg agatgtgcat 3465421 gccgttttcc ttcgcccatt caaactcttc tttcatgccg gaacggattc cgaatgaata 3465481 cacattgtgc ggtccgatca attctgccgc cttacggatc ggcgtggagt gagaaagcgg 3465541 ttctccctca taatcaacac gaagatctgt atgtgcgtca aaatggataa tcgcaaggtc 3465601 tgggtatttc ttgtacatcg ctttaatgac aggccatgac acgaggtgct ccccgcccat 3465661 acccattggg aacttccctt tttctaaaat gctgtccacg tactcttcaa tcatatccag 3465721 gcttcgctgc ggatttccga acggcagcgg aatgtcgcca gcgtcaaaga agttcaagtc 3465781 agccagatcg cggtctaaat atgggctgta ttcctcaagg ccgattgaca cctcacggat 3465841 tctgcttgga ccaaagcgtg agcccgggcg atagctgact gtccagtcca tcggcatgcc 3465901 gtaaagaatg gcgtccgcct cttcccactc gggacggctc gcgataaata cttttcctga 3465961 ataagcttca tcaaatctca tctataatac cctcgctttc ctgtaaaaaa gcgcaagatt 3466021 cgctcctgcg ccataccttc attatttaat caggtcactc acaaatttcg gcagaacaaa 3466081 cgccgcttta tgaatatctt ttgtgtaata tttcgtctca atatcgaaga aacggctgtc 3466141 ttccactgca agcggatcat attttttcga gccaattgta aatgtccaca aaccgcttgg 3466201 atatgtcgga atgttcgccg tatacagctt cgtaatcggg aagatttcct tcacgtcgcg 3466261 ctgtacattt gtgattaatt ccggtgtaaa ccatgggttg tccgtctgcg caacgaaaat 3466321 accgtcttct ttcagcgctt ttgcgattcc tgcgtagaat ccttttgtaa acaggtttac 3466381 agccggtccg actggttcag tcgaatctac catgatgacg tcatattgat tttcagattt 3466441 tgcaatgtgc ataaatccgt catctacctg cacgtcaacg cgcggatcat ccagtttgcc 3466501 tgcgatagaa ggaaggaact ttttagagta ttcgataacc ttgccgtcaa tatctacaag 3466561 tgtcgctttt ttcacgcttg ggtgcttcag gatttctctg ataacgccgc cgtcaccgcc 3466621 gccgactacg agaacgtgct ccggatttgg gtgcgtgaat aatgggacat gcgccaccat 3466681 ttcgtgataa acgaattcgt ctttttcaga tgtcatcacc atgccgtcca aaaaaagcat 3466741 gttgccgaac tcttctgttt ccaccatttc taaatgctga aactccgttt gttctgtatg 3466801 taacgtcttg ttaaccttca tcgtaatgcc aaagtttttc gtctgcttct ctgtgtacca 3466861 aagttcgctc aattgtcatc tccctttcga ggctgtattc atttattgta agcgtcttat 3466921 cagcttttat tctcggttga aatctcattt tcacctaagg aaaaagtata gaggatggcg 3466981 gggaaaaagt aaagatgcgt cctgttctgc gatgtttaaa aacgatcttt ttttctcata 3467041 atagtagaaa cataaaaaaa gggggaaccc gttgtggatg caatgacaaa taaacggctg 3467101 agactgacgc tgaaaaccgt tcgcgccttt atctttttag gggcttttgc ggccttggcg 3467161 gcagctgctg tgtttatgac tgtcattttg atagccaaat accagggcgc tccctcggtg 3467221 caagtgccgc aatccacgat tttgtacgcg agtgacggct caaagctcgg ggaaacgaac 3467281 tacggcgaaa agcgctattg ggtcccctta aaggacatga atccgacgat cgtaaaagcg 3467341 acagtggcga ttgaagacca gaatttctac gatcatcacg gctttgatta taaacgcatg 3467401 gccggcgcgg cgcttgctga cctgaaagca tttgccaagg ttcagggtgc aagcaccatc 3467461 acccagcaat atgcgagaaa cttatacctt gaacacgaca aaacgtggaa acggaaatgg 3467521 aatgaggcgt tctacacgat ccgtctggaa caaaactatt ctaaggacga gatattagaa 3467581 ggctatttaa atacgattta ctacggccac ggcgcctacg gcattgaagc agcttcccgc 3467641 ctgtatttcg gcaagcatgc caaaaacctg acggatgcgg aggcggcgct tttggcagga 3467701 atcccgaaag gcccttccgg ctattcaccg tatgtcaatg agacgaaggc caaggaacgc 3467761 cagaaaacga ttgtgcggat gatggaaaag cagcagatga tcagccaaaa gaaagcggat 3467821 gaattgatca aggaacctct ttcctatcag cctttgaata aacaagtttc caagagaaag 3467881 gctccttatt tctacgacaa tgcgatgaga gagctggaaa aaaagctcgg catgacacgg 3467941 gagcaaattg aaacgagcgg gttaaacgtc tatacaacgg tagataaacg gatgcagcgc 3468001 atcgccgagg agaccattac cgaaacggtt aacgcgggct ctgacattca agtcgggttt 3468061 tcagccattg atccccgcac cggaaacgtt ctcgcccttg tcggcggcag ggattatcaa 3468121 aaaagcccgt ttgaccggac gacacaggcg aagcgccagc ctgcttcgac gatcaagccg 3468181 ttgctgtact ataaagcgat tcagagcgga tttacgccag tcactttgat gaaaagcgaa 3468241 gaaaccgagt ttcaaattga tgcaaaggga gaaacctatt ctccaagcaa ctataacgga 3468301 tactatgcca acaagccgat tacgcttctg caggcgctgg cgctttccga caatatttac 3468361 gctgtgaaaa cgcatctttt tctcggcacg aacaaacttg taaagacggc aaaggaattc 3468421 ggcattaccg cccatcttca agcactgccg tccctggcac tcggcaccga acccgtacgt 3468481 ccgattgaga tggtcaacgc ctatgccatg ctcgcaaatg gcggaaagaa aatcgaaccg 3468541 acttttattt caagagtaac ggacgcagcc ggccacgtgc tgtacgaaaa cccgaatcag 3468601 cataaacagg tgcttgatga aaaagccgct tttgtcacag cgagtatgat gacaggcatg 3468661 tttgatatcg atttaaatgg atatacgtcg gttacggggc gaacgatagc caaccgcctg 3468721 acaagaacgt atgccggaaa atcaggaacc accagcgcag acagctggat gatcggcttc 3468781 aatccgaagc tggccgccgg tgtttggacc ggctatgaca aaaacagcac catcgactcg 3468841 gtcgaagaaa aaagctatgc taaaaccatt tgggcggact tcatggagga cgcgctcaaa 3468901 ggcgaaccgg aaaccgcgtt caagccgcca aaaggcgtaa ccggtgtgta cattgatccg 3468961 gaaacaggct actcatcagg tcccggctgc gccgctaagc attacacata ttttgtgaaa 3469021 gggacagaac ccgcaaacgt gtgctacggg gcagaacccg caaaacaaac aaaagaccgg 3469081 cttccatcca aagaaaagcc cgcttccgag aaaaagtggt gggacaaatg gctggggcga 3469141 catcattgaa aataacccgg ctcctcggag gccgggttat tcgtatggtt ccttcataat 3469201 cgatggaaga atgttagaca atcgagctga acaatcagtt ttgggataaa gtggtgaatt 3469261 tctcatttct tcggcgctgg ctttcatctc ccagtcgccg actcatatcc ccctaaaaat 3469321 gaaaaacccc gagtcttgtt tcggctcggg attttccatg tcctatttct gtatcaccag 3469381 tttactcaat gtttacgaaa aatatctcaa atactttaaa agttcacaaa aaattcataa 3469441 attaattgtt ttctggaagc aggctcgttt ttaactcatc tgaggaacgg tcccataggc 3469501 cctgatcatg ctttttcaga aattcgccta gtacacgctt cgagctgtcg tccattttat 3469561 caacgatgat tttccgtttc atggatttat ccatcagatt cacatgctca ggcagtgact 3469621 tgtagcctct tctgatgctt ctgtcgaccg tcatttcaca ggctgtcaca ccagcgtaat 3469681 aaggcccctc ttcttttctg tcaatcgtta cccacacaag ccagtatggt tttccgttcg 3469741 gcacttcttc tttattcggg agaaatttaa ttcctttttc aacggtgctg cgggcatgca 3469801 tagcgccgat gtctacgaac gcttcttttt cctctacatc aacgaatacg ggagaaatgt 3469861 tatcaaggct gagtgcccct acgccaaaac cgccgtgtcc gtctgtcgga tcacttttga 3469921 taatattaaa cccgattgat tttttctttt tttcttccat gaagttctac ctcctacaaa 3469981 agcggttgaa atatcgctga aaacagcttt aaaatcgaat ctcttcctgc attgagcatc 3470041 ggccacagca cgtaagatcc tagcggtgtc acaaacagca ccaaaaatac gataaagccg 3470101 tagctctccg cctgcgtcat tttggcacgc acgcccggcg gaacgagatc ttctataatt 3470161 cgatagccat cgagcggagg aagcggcagc agattaaata aaaacaagac aagattcagc 3470221 tgtatccaaa tagaaaaaaa ctgatccagc cccgtgctga acgccgcaag catttccatt 3470281 ccgtacgcat gcatcaacac taacaaaaag aaaccaataa acgcaagaat caggttactg 3470341 acgggcccgg ctatagatac gagcacacca gcaagccggg gtttcttaaa gaaacggcga 3470401 ttcacgggaa tggggcgcgc ccacccgaat ccggccacca gaatcaaaat ggttccgaac 3470461 ggatcaaggt gtttaatggg attcagcgtc agtcttcctt gttttttcgc cgtatcgtca 3470521 ccgaatttgt atgcgacata agcgtgggca agctcgtgca tcgtaaacga cacaattagc 3470581 gtgatgacga ggtatggcat taaagataac ggataatata aaaaacggtc caagtgagat 3470641 atccctcttt ctcaaaatgc aagaatttac tttattcagt atactataag aagcctcttt 3470701 ttctaaagag aggaaacgag ataaaggagg attcagcacc catgccatac gtaactgtca 3470761 aaatgctcga aggccgtaca gacgagcaaa aacgcaatct tgtcgagaaa gtaacagaag 3470821 ccgtaaagga aacaaccggt gcttctgaag aaaaaattgt tgtctttata gaagaaatga 3470881 gaaaagacca ttatgccgtc gcaggcaaac gcctgagcga tatggaataa tctctataaa 3470941 gccggcgctt cgcgcaccgg cttttattat ccctattgag ccagcttcgc aataatcgcc 3471001 aagaacgtct ttttctcttc ggctgttaaa cgttcaaaca tgccatcaat cagctgctgg 3471061 cggttttcga tcatttgttc agccgctccc cggcccgatt cagaaagagt aatccataca 3471121 gtgcggcggt cattgttatt tctggatctc tcaataaacc cttcctgctc taaatgattc 3471181 agagctgtgg tcgtggcaga gggagacagt gtgacctcct tcaaaatatc ctttatggtg 3471241 cagctcccat gtctgtatat gatccgcaga ataaaccctc ttacattatt cacgtgtttc 3471301 ggaacggtgg cttcatctaa ttgcttcgtg cttttcaaat actttgtaag tgcgtgatcc 3471361 agcaaatttg cttccagttt gtcatggtcc atgtcaattt ccccatttcg agatgcattc 3471421 ataacatacg aacgatatga tttacttatt attttactga ttccgaatag ggaaagtcaa 3471481 aaaagcaaaa tgtgaattca cagcttttat cctacatgcc tcgattttcc acctgtttca 3471541 caagtttatc tttaaaagtt tggaaaggaa cgtgttcatt ctgctgatgt ccgaatcggc 3471601 ggacgtttac cgcattctcc tgctcctcat gatctccaag caccagcacg tacggaattt 3471661 tttgcacctg cgattctctg attttatagc cgagcttctc attgcgctca tcaatgccgg 3471721 ctcttatccc cgcctgcttc agctccgcct gcacttttct gcaatagtct aagtgaacgt 3471781 gcgaaaccgg tatgatttga acctggatcg gtgcgagcca gactggaaaa gccccaccgt 3471841 aatgctcgat caaaatgccg aagaaacggt cgattgagcc gaaaaccgct ctgtggatga 3471901 caacgggacg aaccttctca ttgagttcgt tgatatatgt taaatcaaat ttttccggca 3471961 tttgaaaatc aagctgaatt gtcgcgcatt ggtggctccg tttcagggca tcttttatat 3472021 ggaaatcaat tttcggcccg taaaacgccc catcgccttc attgatctca taagagaggc 3472081 caagctcctc aaggacgcgt gctaaggcac gttccgacgc ttcccaaagg ctgtcatcgc 3472141 ctaatgaatc ctccgggcga gtcgaaagct caacagaata ctcgaaacca aatgtccgat 3472201 atacctcatc aatcagccga atcgcttctt tgatctcact ctcaatctga tcctcccgaa 3472261 cgaaaatatg ggcgtcatcc tgacagaacg tccgaacgcg aagcattccg tttaaagcgc 3472321 cgctgtattc atggcggtgc acctgtccga attccgccat gcgaatcggc agatcccgat 3472381 aagaatacag gctgttttta aagatgagca tgtggccggg gcaattcatc ggcttcattg 3472441 cgaatcttgt atcatccact tctgaaaagt acatattgtc gcgataatgg tcccaatggc 3472501 ctgactgctc ccataaccgc tgattcatca taaacggcgt acgcacctca tcgtagccgg 3472561 catttgtttg cagctcacgc gagaagcgct ccagctcatt gcggacaatc tgccctttcg 3472621 gcaaataaaa cggcatcccc ggcgcttctt cagaaaacat aaacagccct aactgtttgc 3472681 cgagcttgcg atggtctcgt tttgccgctt cttctagcat atgcaggtgc gcatccaaat 3472741 cttttttctt ttgaaacgca accccgtaca cccgctgcag gacttcattt ttgctgtctc 3472801 cgcgccaata agcgcctgat actcttgtca gtttgaacgc cttgatcatc cctgtagaag 3472861 gaagatgcgg ccctcggcac aggtcaacga attccccttg ctggtacagt gtgatatcct 3472921 ccccgcgcgg aatatccttt aaaatctcaa gcttgagccg ctcgtctttt tgtgcaaaca 3472981 gctcttcagc ttcttcgtaa gaaacctcta tacgtttgat ttcaaggttc tcatttatta 3473041 tgtttttcat ttctttttcg atggcctcta agtctcctga tgccaagctt ttccccagct 3473101 tcatgtcata gtagaagccg tctaaaatca caggccctac ccccaatgac acttcgccgt 3473161 acagccgttt tactgcttgg gccagcacgt gcgctgttgt gtggcgaagc acctgcaagc 3473221 cttcttgtga atcgagtgtg acaatcgaaa gctcagcatc ctcctccagc ttgaaactga 3473281 gatcaacaag cttgccgttg acctgacctg cggccgcctt cttttgcaga ctggaactga 3473341 tcgaaccagc cgcttctttg attgtgatgc ctttcggata ttcctggatc tgtccgtccg 3473401 gaagctgaat gtgtacatgt ttgctcattt tagaacactc cttattcatt gttgtatata 3473461 aaaaaacaca cccgtcccgc agatagggac gagtgtgtga ttaacccgtg gttccaccca 3473521 agttcccgac aaatactatg ttgtcggctc ggtgctgtaa cgcagcatag acggcattgg 3473581 ttacttcagt tccccaatgc tgctccaagg cggtaaatga tattcctaag ctgggaagct 3473641 ctcacctttc cttccctctc tgaaaaccgt aactatcatt catgtccttt tcatcgcatg 3473701 tattcaattc ataaaaaaac acacccgtcc cacagatagg gacgagtgtg tgattaaccc 3473761 gtggttccac ccaagttccc gacaaatact atgttgtcgg ctcggtgctg taacgcagca 3473821 tagacggcat tggttacttc agttccccaa tgctgctcca aggcggtaaa tgatattcct 3473881 aagctgggaa gctctcacct ttccttccct ctctgaaaac cgtaactatc attcatgtcc 3473941 ttttcttcgc atgtattcaa ttcaaataaa aaaacacacc catccctcta aaagggacga 3474001 atgtgttgat catccgtggt tccacccaaa ttcccgatca attacacatg atgatcggct 3474061 taaagatgct gtaacgcagc atgacggtat cagatacttg ttttccctga tacggctcaa 3474121 aggcggtaag ctgctttccc tgcgttagga agatctcagc tgtccttccc tctctggaaa 3474181 ccgtaaaaag catctcgtgt ccttatcagt gcctgttgtt tcaataattt tttatatctt 3474241 actatatatt cccacaaagc gcaatcagtg atttacattt tttctgacgc ggcagtcccg 3474301 ttatgggcag ccagaaacag ccatacaagc aatgcagcga ggctgtatgc cgctcccatc 3474361 atcaaaaacg caaacccggc accagcatac caagtggcgg acagatgaat gatcaccccg 3474421 gttatcgcta cgccgaccaa ggctccgatt tgccggtttg catttaacgc cgcaccggcg 3474481 atattcgtat gtctttgccc ggcagcctgc atgatcacag ttgtcatggc aggaactgta 3474541 ataccggtac agaggttcat aacagacatc aacaccgcca gctgccaata aggaaaatcc 3474601 ggagaaatca gcacaaacaa cagcaatgca atgatacagc tgaccgccat tgatacaaac 3474661 ataagctgac cggcttcaaa ccgattcgcc agacgggcaa acagcagatt gccgatcacg 3474721 aagaccgcca tcatcggcag cagctccact ccagccataa aggaacttgc ccctcctgct 3474781 tcctgcaaaa aaaggctgag cataaacatg ccgccaaaaa gggcgaaatt cagcaaaaac 3474841 ccgataaatt gggcagctga gaagcggccg tttttgtata aggacgccgg caggatgggt 3474901 gtttttgcag aaatttcccg cagcaaaaac agcacaaatg ccaaaaccgc tgcagtaaat 3474961 gctacaagaa tcactggcga gcgccagccc gctgaaggcc cctgtatcaa agcataggaa 3475021 agaaacccga gagccatcat gccaagcaga tgcccgatga tgttcacgcg gctgcttttc 3475081 ccaggaacgc ggctgaggat tcggtaagct gaaatgagcg cagcagcccc tattggcaca 3475141 ttgatcagaa aaatactctg ccagcccgcc aactgtacca gcacgccccc gataaaaggc 3475201 ccaagggctg aagcggcgga aacaagcgcg gcccacagtc caaacattct cgcccgcgcc 3475261 cgctcatcaa ggtaagaggc agccaaaagg ctgagtgagc ttggcataaa caaagctgcc 3475321 ccaattccct gtatgagacg tccggcaatc agcatctgcc catttataga tgcagcgcat 3475381 agacaggagg ccataacaaa aacggctaga cccaagatat agatcgtctt cgagccgaaa 3475441 cggtcagcca aggctccgcc cgccagcaga agcgacgcaa aagtaagaat gtacccgtcc 3475501 acaacccacg ttacacctga aagtgacatt gaaagagtgt ttttcatatc agccatcgcc 3475561 acattcacaa cggtcacatc aagagttgcc atgaggaaac caagtgcgag cacgatcagc 3475621 acggatatgc ctgttgatga tgttgattct tgtatagacc cgctattttt cattacaatt 3475681 gccctttcac ttgcttgatt acccaatcat ctattttttc aagatcatac aattccccga 3475741 ctctgtccat aacatgctgc aaggattctt ctctcataag attggaccat ttatcctcga 3475801 tttccgccat gactgtctcc agcacacagt gactttcacc ctcaaataca gattgcagca 3475861 agcctttccc ctgatacatc gaacctctgc cttcgaccgc ttgataaaca tcataaagcg 3475921 taatgtcagc caaaggcttc gtcagggtaa aaccgccctt cgtccctggt aaggattctg 3475981 ccaaaccggc ttgaaccaat gttctcatca gcttcttcaa gtaagacgga gacacgcgca 3476041 atcgctggct tatagcctct gacgtcaaag aagcctgtac cggcagccgt gacagtaaca 3476101 gcagcacaga aaccgcctgc tccattcctg atttcatttt catcctattc actcctgatt 3476161 cattatggat aactattatc cataatgaat ctcttagcag cttttgtcaa taaaaaaagc 3476221 aaaagaaacg gatcatttct tttgcttggt atggttaaca aatctgcttc agttcctcta 3476281 tgtattgaag cgcttcgtca tattcttcat ttgtatattt ttgcttgctt ttgatggtaa 3476341 agactttttc tttcttttcc tcatcctcaa gcccgtcaaa gtaaaggatc gtggaaacca 3476401 gctctaaaaa ccgtgatgaa cggctgttta cactgtcgat atagcctttc atatccggca 3476461 tgtccagatc agcatggtct aaaaatgcgg agcctgtctc agtcagcgaa taccggtatt 3476521 gaaagtagcc gccctttttt tccttcacct catgcagaaa tccaaggttg cacagctctt 3476581 caatctggag cgtcagttcc tctgaatatg gtccgtaaaa gtgaaaatca tatttctcat 3476641 agaaaggaaa ctgcattttc ttggcgatat aaatcatttt ctgcagcttc tttcgcccga 3476701 tgatttctcc agaatccgag aacaccttca tcagttttgc atgttctttc aacaaattcc 3476761 cgacatctcc tttttccttc tttccaattt ctatgtcagt cccagcagct gccggatttt 3476821 cattttcgct tccggatgtt tagtgccgtc acaaatcaag tcctttggat agtacagctt 3476881 gtggtccgtc cgccgtttac ctgagatgga ttccacaata gccgactgtc tggacagctc 3476941 tttaatttgg ccgttttgcg tcaagagatg gatcggcaga cgctcctctt cctctcctgg 3477001 tcggtaaaaa tcgtatggca gatctgatga agaatcaacg accaaataat agctcggatc 3477061 gatccccgcc tctttgaaca atgaagtcag ctcaaaataa gccgacattt cttcattcgg 3477121 attgaattca acgtattgga aaagctggcg gttaatgaat ctgcggcaca agtcggataa 3477181 aatcgcgtct tcttcatcct cccaggcctg gaagtaatac aaaataatag attcatccag 3477241 ctttacataa tcctccagtg tcaattttcc ttcaaaaata gaatagaaat gaaccggagc 3477301 gtgagtgaag acatagcctt catcgtgcag ctgcttcgcc ctgtgaagaa tcttcgttaa 3477361 aatgacctct gcacttctag tcacaggatg gaagtagacc tgccagtaca tttggtaacg 3477421 gctcatgata tagtcttcga cagcgtgcat tccgctttct ttaatgacga tctgatcctc 3477481 gcgcggccgc atcacccgaa gaatccgctc catatcaaaa tggccgtagc tgacgcccgt 3477541 ataatatgcg tcgcgctgga ggtaatccat gcggtctgcg tcaatctgac tcgaaatcag 3477601 gctgaccact tgcttgtttt tatatgtttt ggcaatgact tcagcaacat cctgagggaa 3477661 acccgggctc acctttctga gcacctgatt aacctccgtg tctcccaaaa tgatacctct 3477721 tgtaaaatcc tcgtggtcaa ggtgaaagac cttttcaaat gaatgcgaga acggcccgtg 3477781 cccgaggtca tgaagcagcg ccgcggccaa acagagttcg cgctcactgt catcccattc 3477841 agggcggcct ttaaagacgt catcaaccat tcttctgaca atttcataga caccgagaga 3477901 atggttgaac cggctgtgct cagccccatg gaacgtcaaa taggtcgttc cgagctgctt 3477961 aattctgcgg agacgctgaa attcacgggt tccgatcaaa tcccatatca gcttgtcccg 3478021 aacatgaaca tagcggtgca ccggatcttt aaacactttt tcttctgata attttccatt 3478081 tggatacgcc atcgtcattc cctctttttt ttagccgtgt ttctattata tcgactctat 3478141 tctttgaaaa catccttgaa tttgcccggc gatttgttcc atcttcatga aaaacacatc 3478201 ttgtgaagca aaaaagcctg acctgagggc cgaggctaag aaaaaatatg tttttacttt 3478261 tttattttct tttttacttt gtcaatcagc tcatcctctg tcggagctga cagcgggcga 3478321 ttgttcacaa aagcaaatga ttttttccgt ccgggcccgc aataagattg gcatcctacc 3478381 tcaacctttg cgtccgggtc cacttctttc aaacgcggca gcaatgtttt gatattagtg 3478441 gcttggcaat catcacacac tcgaaattca ttagccatga cgtacgcttc ccttcatttc 3478501 tatgttcatc tatgtgaata acctaaaatc acgtttcaaa aaaaatcaca tcacacttca 3478561 ttttacaagg attcgactgt tcctgcaagc cgctccatcc ttcgtatctc ctattctttc 3478621 agccaatttg tataaatatt ttccaacctg gacattctaa taccatgaaa agaaaaatgg 3478681 gagttgagat aaatgacaaa acagcgacaa gacgcttggt cagaggaaaa cgatctgctt 3478741 ttagccgaaa cagtgcttcg gcatgtgagg gagggcagca ctcagctgaa cgcctttgaa 3478801 gaagtcggcg ataaattaaa ccggacatcc gcagcctgcg gattcagatg gaacgcagtg 3478861 gtccgccatc aatatgaaaa agcgcttcag cttgcgaaga aacaacgaaa acagcggatg 3478921 agagcgctcg gaaacgggca gcccgcgaaa aaaagattat tatatcagcc tcctgccgtt 3478981 gatcctgaaa tcattcaaga aaccgctgca gaagagccgg ttaaaacgga aacaccatct 3479041 gtcgaaaatg agcaaccttt aatgtctggc gaacacatgc cttttgttga tgaaagcttt 3479101 aaggaagagt tagctagtct atcacactta ttgtctcctc aaacgcctgc agctgcgcct 3479161 gagatgacga tgaatgatgt gatccgcttc ctgcagaatt acgaaggcaa tcacgagcaa 3479221 tcatcagcat taaaaatgga aaacgagcgt ttaaagaaag aaaatcagga attgcaaaac 3479281 aaaacagagc agctagaggc agaagttcaa aagcttgaaa aagaccaaaa aacgatccaa 3479341 gaagattatg aaaccttggt gaaaattatg aacagagcca gaaagctagt tttatttgaa 3479401 gaagatgaac atgcctctcc gtccttcaaa atggaccgga acggcaattt agaaaaatta 3479461 gcggaatgac atagaaaaat cccaaaacgg gcagctgttt tgggattttc gccatgtgca 3479521 aaatcccctt ttctattgag aaaagagaat ttcctcattt tgcagccgga tcagctattc 3479581 ttgtaaaatg aggccaagct tatgtgaatc tattaagaca tgtgagctgc ctcggccgtt 3479641 ttttgtttcc gaggcgcagc agaaatgacc aaaagcccca gcatcataag cgcaatgccc 3479701 agccacgagg aaggcgaaag catttcccct atgaaaaaca cgccaagcaa tgaagccgtc 3479761 agcggttcag ctaaagacag cgtgaccgcc gccgaggccg gaaccccggt aagccctttc 3479821 gcaaacaaaa agtatgcggc acatgttgca attaacccga tgtaaaggct tgttcccagt 3479881 cctctagggg tcaatatcca cgagatatct aactgccata atagcggcgt cagcaagatg 3479941 gcgctgatca tgaatacaac ggcggaggtc gctcgcggag gctgggtttt catcatcgct 3480001 ttactgatga gcgtatagcc tgcaaaagaa gcacccgctc caagcgccat aagaacacca 3480061 gccacatcaa tccgaacatt ggaactgtcg gaaaacagaa gccagcaacc cgctaaagcc 3480121 agcacagtcg caatccacca ggagtttcgc gggcgtttct tcaatacagc ccattcgagg 3480181 gtcccggcaa tgataggcgc actgccgatg gcaatcacag ttcccactgc aattcccgtt 3480241 tctttaaccg ctgtgaaaaa cagcggctgg taacacgcca tacaaacagc ggctaaaaat 3480301 acgagcggcc atgcccaatt tttcacgtga agctcccggc tgatccaaac cgcaagcagc 3480361 atggcgcttc ctcctattaa taacctgaac gctccaaatg ccagcggtgt ggcgctttct 3480421 ggagccaatg cctgaacggt tcccgtggtc ccccagaaaa aagccgcaat caatacaaaa 3480481 aggctgtaaa tattcccctt catctgcctc tcccctttaa tatggatgct gatgtcattt 3480541 tatcgttttt ctttttgtcg tggttatctg tatgtaagaa ggacttatct gaaaataaga 3480601 ttattgaggt aaaatgccgc ttgagataaa aaatgcatgc cggcatatac agccggcatg 3480661 cgaagaacgt tcacccaaat acctttgcat tccgctcagc catccggacg aggtttttct 3480721 caaattccat ttcctcatca atggacagtc cagctgaata aagatgggtg cttaacgctt 3480781 ttaattccgt caataaagcg aacattaagt cttgtacgga gatgtctttt tgaagaagct 3480841 cacttaagga cgccatcgtt tccggacgta tttccggata gacgcctttt ttatcgtttt 3480901 gtttgtcttt cagcgccgct tgatagaatc gtctgatcaa gtcggccctt tcactgccgc 3480961 ttttatctgc acagagataa atttgaacag cgactccgcc gcgaacgcgt ctctgagaga 3481021 tgccggcgaa ctttttgcca tttatactga ggtcatagct gccgggacaa taagaccctt 3481081 caatttcata ggcttcgatc tttgcgttgt acggtctcag cattcgtctc atcagctcga 3481141 ccatcgcttc atatcctttg tctatatcga tgcctttctt ttcgtcctcg aatatgagag 3481201 agatatttaa aacaccgtca tccaatacga cggcaagacc gccggaattg cgtacgatca 3481261 cacggtatcc ttcgctctcc agcaaggaga taccatcctg caaaaacggg aggcgtgtat 3481321 cctgtattcc aaggacaatt gtatcgtggt gcacccatga gcgcgctgtc gccggcgaca 3481381 cgccttttcc gacggacatg catagcgtat catccattgc gaaggattgc ttcgcatcaa 3481441 ataaagggcc gagactggat tggtcaatga ctctccattt cggctgcatc agtaaatcaa 3481501 tcggttggtt tgccatctat gtaaaaccct ttcatgttag gcttattgaa cgaaaactat 3481561 tatatcattt cagcagctgt gattgataat tgcttttcag catcgtaata aaaatttctt 3481621 tattttttgt attctccatg agaggagaat gaatgtaaga cagcttgcgc tttaacgaga 3481681 aattattaat atgcagaatt gaaatttcgc ggtggatcaa atccttacgc agcacgcttc 3481741 tggatagaac cgaaagtccc atgccgttaa tcaccgcttc ctttacacct tgattgctgc 3481801 tgatggtaaa cattgatttc ggccgaagtc catttgaact gagtacatga tcgagatatt 3481861 ctctcgtccc ggagcctttc tctcttgtca cccacgcttc gttctgcaaa tcgctgatcg 3481921 aaatctcttt ccgcccggcg agcggatgct gatttggagc ggcaatgcac atttcatcct 3481981 ccatgaacgg ttcaatttcc agctcattct cgtttgtatg tccttcaatc agcccgatat 3482041 cagcctgaag catccgcaca cgctcgctga cctcctctgt attgccaatc atgacatcta 3482101 gattcagctc tggatacagc ttttgcagct gggccaatag cggcggaaga atatactcac 3482161 cgattgtaaa gcttgcagct attttcaatt cacccttcac atagtgatga tgcgcataga 3482221 tttcagcctt ggcttgttcg tagagaaaca ccatttgctt tgctctttga tataaaatgt 3482281 ctcctgtcgg cgttgtcgta aagtgttttg gcgacctgtt cagaagagcc gtttgaaatt 3482341 ctttctcaag atttttgata tgcagactga cgctgggctg ggagatcatc agcttttccg 3482401 ccgcttttgt gaagtttttt tcttctacca ccgctataaa cgttttcagc acgtcgtaat 3482461 acaaaaaccc cacccctgtc attaatgaaa tatatggtta tgattagttt tctttattgt 3482521 actcatatca tccgtcttgg taaagaaggg ctatacagaa gcgcaaaaaa ggcagccctc 3482581 ggtcgagagc tgccattgtc ttcaatttta ttacagtgct tgcgccgctg taattaatgc 3482641 gagattgtaa acatcttcag cgttacatcc tcttgaaagg tcgtttacag gcatatttaa 3482701 accttgcagg attggtccta ccgcttcaaa gttgcccaaa cgctgagcga ttttatagcc 3482761 gatgtttcct gcttcaagac ttgggaatac gaatacgtta gcgtcccctt tgatctcgga 3482821 atccggcgct tttttctcag ctacagatgg aacaaatgca gcatcaaatt ggaattcgcc 3482881 gtcaagtgtc agttcaggcg ctttttcttt cgcgattttc actgcatccg ctactttttc 3482941 tgtttcatca gattttgctg agccttttgt agagaagctg agcattgcca cgcgaggctc 3483001 aatgtcgaac atttttgccg tattggcact ttcgatcgca atctcggcaa gatcttggct 3483061 gtcaggtgca atgttgatcg cgcaatctgc gaatacgtat tgctcttctc cgcgagccat 3483121 gatgaacacg cctgaagtct ttttcacgcc ttcttttgtt ttgatgattt gaagagccgg 3483181 gcggacagtg tcagcagttg agtgagcagc tccgcttaca agtccgtctg caagtccttt 3483241 atacaccagc attgtaccga agtagttctc gtctaataat gctttacgag cctgttcttc 3483301 agtcgctttg cctttgcggc gttctacgaa tgcttgtaca aggtcttcca tgccttcata 3483361 tgtatgagga tcataaatct taacgccgcc cagcgtaagg ttcaattctt ttgcttttgc 3483421 ttggatctca ttttcattgc cgatcacaat cggattcagc actttgtttc ctgcaagctt 3483481 gctgaccgct tctaaaatac gctcgtctaa gccttcagga aatacaattt taacgtcttt 3483541 tccagctact ttttcttgca ctgttgaaaa taaatctgcc acaataaaac ctcctcaaaa 3483601 agttacaaaa acgctttctt ttactagcat actcttcttc caatcaaatt caaacagcca 3483661 actttcatta tagcgctttc ataaaaaaat cttatttttc taactaattt aagtgactca 3483721 atcttccctt ataggttctt ctattttgat ggagttatac ggaagggatg ttcaaggttt 3483781 ctccacagta gaatcggata aactatggta tagtgaaggc aatcatgaaa agataatggg 3483841 agtgaagata aatgagtgaa cagcaaatga cgaatgaagc ggcaaaaacg cttgacggct 3483901 ggtatgcgct tcatgatttc cgcacaatgg attgggcttc ctggaagctt ctgtccagtg 3483961 atgagcgcca atctatcata catgaattca ccgggttgct tgaaaaatgg ggcgtagccc 3484021 aaaaagaagg aaaaggatcg caaactcttt acagcatcgt cggccaaaaa gctgatttta 3484081 tgctgatgat ccttcgtcct acaatggaag aattaaatca aattgagctt gaattcaaca 3484141 aatcaagact tgctgagttc accattccgg catactccta cgtatcagtg gtagagctga 3484201 gcaactactt ggcaagcggt gacggcgatc cttatgaaaa tccgcatgtg cgcgctcgcc 3484261 tttaccctga actgccggaa tctaaatatg tatgcttcta tccaatggat aaaagaagat 3484321 ctggcaacga caactggtat atgctttcaa tggaagaacg cagaaacttg atgagaagcc 3484381 acggtttaat cggccgcagc tatgcgggca aagtcaaaca gatcatcacc ggctctgtcg 3484441 gctttgacga ttacgagtgg ggcgttacat tatttagcga tgatgtcctt caattcaaga 3484501 agctagtgta cgaaatgcgt tttgacgaag tcagcgctcg ctatggcgaa tttggttcat 3484561 tctttgtcgg caatcacctt tcgcttgata cacttcctca attcttatat gtataatatc 3484621 ccctcccgcc ctatccggcg ggagtttttc aattctcctt tatcagaatt taaataaaat 3484681 ttgctatttt cttcgttttt tcttacgatg tagataataa tccatttttt tcaaaggggt 3484741 gcagttattt gtcaaaacga accgcatttg ttatgggagc cagtcaaggg atcgggaaag 3484801 caatcgctct gaaattagca gaccagcact tttccctcgt cattaattcg cgaaatttgg 3484861 ataatattga atctgtcaaa gaagacattt tggccaagca tcctgaggcg agcgtcattg 3484921 tccttgcggg cgatatgtct gaccagcata cgagagcggg catttttcag aaaatcgaat 3484981 ctcaatgcgg acggcttgat gttctgatta ataatatccc gggcggcgcg cctgacacat 3485041 ttgataactg caatatagag gatatgacgg ccacgttcac tcaaaagacc gttgcctata 3485101 ttgacgcaat caagcgtgct tcctcactga tgaaacaaaa cgagtttggc agaatcatca 3485161 acattgtcgg aaatctgtgg aaagaacccg gcgccaacat gttcacaaac agtatgatga 3485221 atgccgcttt aattaacgcc agtaaaaata tttccatcca gcttgctcct cacaacatta 3485281 ctgtcaactg tctgaatcct ggttttatcg ctacagaccg ttatcatcaa tttgtggaaa 3485341 atgtgatgaa aaagaacagc atatccaaac agaaagcaga agaacagatt gcttccggga 3485401 ttccgatgaa acgggtcgga tcagccgaag aaaccgcagc gctcgccgca tttcttgcct 3485461 ctgaggaagc ctcctacatc acgggacagc aaatttccgc tgacggcggc agcatgaaaa 3485521 gcatataaaa acatcccgct ttttagcggg atgtttcttg taatgacccg aacggcaggt 3485581 tcagcttttg aatccgcgtg acaaattccc gcagatcctc ctgcttcgac accattgaga 3485641 ttctgacatg cctttttccg ttgcttccaa aaatttcgcc cggtgtgact acgacatggg 3485701 catgctccag caagtaatcg gaaaattggt gagatgtctc aaacgtattc ggaatttcag 3485761 cccatacgta aaaggttcct tttggctttt ccatcttcca gcccagttcc ttttcacaaa 3485821 gcgccgtaaa aaagtcaatt cgttccttat aaattcgttt caacgattcc gtatgctccg 3485881 gatctccaga aagcgccgca ctcgctgcct gctgcagccc gccgaacatg ccgacaaata 3485941 catgatcctg aaattcattg acggcctgaa tgattttttc gttcccaacc gcaaacgcca 3486001 ttctccagcc ggccatgtta aatgtttttg aaaatgaata aagctctgct ccgacagttt 3486061 tggcatcctc tgcctcaaga aagctggccg gtttttgatc gaattcaaac gccccgtatg 3486121 caaaatcatg aatcaaatgg atgttatgct ctttcgcaaa agcagcagct tttgcataaa 3486181 aagccgcatc agccacagct ccagtggggt tgttcggata gtttaaaaac ataagcttcg 3486241 ctttttccag cacggctgga tcaatctttt caaaatccgg cagatagcca ttttcttcat 3486301 acagcggcat ttcgtaaagc tcagctcgcg ccatcgtaat ccctgataaa tattcaggat 3486361 agcctggatt cgggactaaa gcgatgtctc ccggattgag caggcattgt gtcagcacat 3486421 acaatccggc tttcccgcct ccgaaaagcg cgacttccgt ttcaggattg attgtcactc 3486481 cgtattccct tttatagaaa gcggcgatcg cttcctttaa aaaaggatag cccctgaaag 3486541 ggccgtatcc atgaaacgaa ggattcagag aagcctcccg caaagcctcg acaatatgcg 3486601 gcggagtggg aaggtcaggg ttcccctgtc cgagattaat gatatgggct cccgtttttt 3486661 ccatttcctt taccttttga aaaacgagag aaaactcctg ccttggaagt gtcttgatga 3486721 catcggacgg tgttatttcc atctaaaaga ctcctttttg ctccgttttg ttatcccgtt 3486781 ccaaaaacga tttgttgacg agcttcgtat gcaaaaacaa accgcatacg atcacgacaa 3486841 tcagccccat aatgaccgga gcgcttagga tgttaatgaa cattgaacca atagaaatgc 3486901 ataatccgat agacgcttcg gccactgaaa aaatgcgccc ttgaatctgg tttgccgcat 3486961 tttcctgaac cttcactttt gcaagcactt ccccgtattc catcgcgatg aaaaagagga 3487021 tcgccgcgat gacagaaaca gcgaatatcg gtgtgaataa aaacagcgcc agcgagacaa 3487081 tggataaaac ggtaaagtac gtcaggcctc tattgttgtt aaagccccat ttgctgacaa 3487141 gcgccgctcc gataaagccg ccgaagccga tgcagaacgt gagaataaag ttgccgattt 3487201 ccccgtcacc cagaaagcgg ctgacaatcg gaaaatagct gtacacaact ccccacagca 3487261 aagccattgt aatcatcgta aacatggcgt ttaatacgaa tgaattggtt ttgatttcct 3487321 tgagtccttc cttaaaagac tgaaaggcct ctttaatgtt ttcagattga atcggcacaa 3487381 attgcagctt gatgcggctg ataaaaaatg ccgaaaccaa gtatgtcaca ccgttaaagg 3487441 caacagccag ctctacagat ccgcctaaca gaaagagccc tccggcagcc gccccgacga 3487501 taatggagat ggttgtcgct tttgcaaata acgtgttgat gcttttaata tctgattcca 3487561 aggacgacat gacagcgaga cgggcgggat taaaaaacac gccgcttcca taagtaataa 3487621 acagcagggc cagaaaaatc agcggatact cgccttttgg aagaaatgtg agccccaaaa 3487681 agatgatgcc tctgatgata tccgtccaca gcatgatctt aattctgtct aaccggtcga 3487741 ccagaacacc caaaaacggc tgaaacacca tcggaatgct tctgaccacg atgaccccgg 3487801 acgtcaccca ataatcgtga taatatgtag acaaaatgag cagggcaggg agaacacaat 3487861 agtctcccat gaacgatagc gcctgcccgt aaagcaagta tttagagttg ggtttcagct 3487921 gtttcatact ggcagcacat actttgccgt cagcttcgca tgctgctgaa tttgtctgat 3487981 tgattcagcc acatcctgtg aattactgcc tttcagttca aatgcagcaa tggaattgaa 3488041 agcttcaaac aatgtcaaat caactgaagt gcctggtgct gcggccgaaa aagaaacgat 3488101 ttcagtatcc ccttttaaaa gcccgtccgg aatatcgatc gcttcaatga ccaaatcctc 3488161 agcagtttca ggaatttggc cattttgttt gaaatgctgc gggtacaaat ggcagtcggc 3488221 aacataataa ggctcttgat ccaataatcc gtccggcaga tcggcgtctt ttccgaaaca 3488281 gaggacatct aataataatt gcgccatatc aaggccaaag acctttttaa tattggggat 3488341 catattccag ccggcaaatc tggctgccga ctctattaaa cccggttctc tgtttttcat 3488401 tagcttgatc tctgtatgtg ttgcgcaatt ttgcagtcca agcccttcat ttgccttttt 3488461 ggcagcttcg acaattttct tttttgcctc ttcatccaga atggacggcg taatgtggga 3488521 tgtctctgta aacccgattt gcggcgtttt atcatgaatg gcgatcggga aatactcacc 3488581 gtcagccatg atgccttcta tactgatata gtcggagtac ccttctgttt gataccagtc 3488641 tccgtactca ccctgtaaaa attcttcagc gataaacggc gcttcaaacg taaccgcctt 3488701 tggcacgtta attgatttca gatagtcatt gactctgtta aattcatctt ctgccgtctc 3488761 agtgtccgta atcagcgtta caccgataga actcgctaag tatgtaggct ttaagataag 3488821 aggtgtgccg atctcttcaa gagcagcacg gaaatcttca agagttgtga ctcgtttgtt 3488881 tttgatcgat ttgactccgg ccttattaaa agcgtccctc attttatttt tatctctggc 3488941 attttcggct gcctgcacgc cggcacctct caagcccaga cgttcacagg ctttcgccat 3489001 cggagcaatg aataattcat tgtttgttgt gatggcatcc gccccaaaca tttcggcaac 3489061 cttgacgatt tgctcgacga cctcttcctc aggcttgtta tgatcttcat gcgcccaata 3489121 aatggaatca gggtgttcaa aatcagctaa actcttaaaa tagtctttat cttttatgac 3489181 cgcgaccgag tatttttcaa tcaatgctgc atgggaggct gtaattgcaa aaggtcttgg 3489241 aataaagctg accaggttat atttttcagc agcgctttta taaaacatgt gcggcgggca 3489301 gcctccaaga tcagcgatga ccaatactgt ttttctctcc atatgtaaaa cactccttct 3489361 ctattgtgcg gtgtatcctc cgtctgcggt gatggcgctt ccggtcatat agcttgataa 3489421 atccgaggct aaaaacagca tcacatttgc gatttcttca ggtttcccaa gcctcagcag 3489481 cggatttacc ttcgcttttt cttttttaat ctcttcaagt gtgccttcat tattttcaag 3489541 gaatgatttt tcattcagcg gtgtgtcgat gatccccggg catacgcagt tcacccgaat 3489601 ttgatgtttc gcataatcaa cggccattga tttagtcagc tgcaaaaccc cgcctttgct 3489661 ggcgttataa gcaggaatat caggccatgc cacgagtccg ccgacagagc acgtattaat 3489721 gatgttgccc ttgccggcgg ccagcatatg cttgagtgca tgtttgctca ttaaaaacat 3489781 gccggtcaaa ttgacttgca gcaccttgtt ccaatcgctg agctccatct cgtgaatagg 3489841 cgccacgatt tcgatgcctg cattattaat caagacatcg agcccgccaa atgtatgaac 3489901 cgccgattca actgcgtgct ggcaggcagc ttcgtctgtg atgtccgttt gcacaaagtg 3489961 cagcctgtca ttattttctt ttcgtaccat tgcttctcct tgcgcttcat caatatccgc 3490021 cacaaccaca ttggcctgct ggcccaaaaa agcctgaacc gcagcataac caatgcctga 3490081 tgcgcctcct gtgatgagga cggttttatc ggtgaggttc atgatcattc atccgccttc 3490141 attttttttg cttttgccct gttatagcgc ggcgggaaga agatattaat cgattttgat 3490201 tctttttctg aacggttgat ggcaccatga tcttcgcgag gctcacagaa ataggctgtg 3490261 ccgaatttca tctcgactgt gcagccttcg accgtcatgt catagccgcc gccgatgcag 3490321 atgcctattt gttcattccg atgtttatgg aaaggcattt ctccgccatt tccagggatt 3490381 ttggcaagca taatttctac ccaatcctca acaaagaacg tgacttccat gcccggcagc 3490441 aggtctcttg ttttgaaaat atccaaaaag tagtcctcag gacttgtata tgtttcatca 3490501 gctttcagcc gcttgatatc aatagcaatc acttcttggt ctgtgtcgtt tcttgccccg 3490561 tgaggcacat gcggcggcgc gatataggca gattccaagg ctgtcatttt tcttgtcaca 3490621 tctccgacag tcatcatcag ctcgccagaa acgaccatgc cgatttggac ctccttatgc 3490681 tgatggggtt caacattggt atgcggcggg acgtaagaca ttaatacttc agtatcccct 3490741 cgtacggttg aatactgcct cactccgttt tcccattcaa ttaatttcgg tgtcgggaaa 3490801 taaagctcct gcatatcttc tttagttttc atcatcaacg tctccttttc caaataatga 3490861 ccagctcatt ggaatgcttt tgaatgtttt tacaaaggtt agcccgtact tttgccgtgc 3490921 aagctcattg gttaaggcaa tgtcatacaa accttctttt acttttcttg cggcttgact 3490981 ggttgaattg actagtttga aacgaacatc tttgcgggta aaatatttta ttaaattaat 3491041 aggtgaagga tgtgaaacaa taacagatgt atcaagcata tcgtctctga attcaaaatc 3491101 aggacgaaca gccaggccgt acatcggtgt atcgcacctg aagatctgca atagctgcaa 3491161 atccggcctc atgtagaaat gcttaatgcc atcgtaagca tgtgggacga tggtatattc 3491221 cagcgggctt tggagcgtcc tttcgatgca cgattcaaaa gtatcatgca aggacaattt 3491281 actgttcagc ccttgtagaa gagtaaaatt ggaaatgaaa tgctttgctg cgtactcact 3491341 gcttgtcccc tcagggccga gcgtgttgac tgtaatgagt ttggatagtg aatcagttct 3491401 tttttttgtc tgaatgctat tatccaatat aatcatgagc accaaccaat cttttaaaat 3491461 tttaagtaaa ttttatccag tggaaattga actgtcaatg ttttttgaaa atattgataa 3491521 ttattcccat acaaacaaaa aaacccttta aaaagggttt ttaattatag gaatttagaa 3491581 actttgttta ttgagataag gactgatcgg ccttctgctc aagtttgccg tactttttat 3491641 atgcgaatac actgagcaca aatccgagga ctgtgatggc ggcgcaaatc aatccgacag 3491701 ctgcatagcc gtatgccaca tatacgggtc ccattaaagc agaacctaat gtcacggcca 3491761 gattcgaggc gagactgtaa aacaccatga cttttcctcg atgacgctct gagcagtcac 3491821 tcaaaatggt gctgagcagc gtcaccgtca aactttgcat taatccccaa ataaataggc 3491881 tggcgattaa cagaaacata gacgccggcg catatggtaa acacgccagc agaacgctga 3491941 tgacccccag cgcaatcaaa agggagcgca tttttccgat gcggtcggct atctttcctg 3492001 taatcacact catggaaaac ccgattccat aaatcatgat aaataagccc gcagccgtgt 3492061 ttcctccggt aaaaacgtcc tgaagatagg tgcctaaaaa ggaatacata ccgtaaaaac 3492121 caatcatatt acaaaaggtt attgtgatat aaacaggtac acgagggact ttcagcgcat 3492181 cccggaatgt tcctgcgggc tcttctattt cttccttgcc gctgttttta tgttgggcat 3492241 ggcggcgcat ttcaaggaga atcagcagaa caactaaaac acccatcagg gcgaaaatcc 3492301 aaaacgtcca tctccaatgc aggacgccgc cgataaatga tccgagcggc actccgaaaa 3492361 tcagcgccag cgaccagctt gaaacgatca gtcccatcac cttgccccgg tatgtataag 3492421 gaacacgatc accgacaact gcgtaagcgg tcggaacaaa cgctcccgca gccaatcccg 3492481 aaagcgcccg gcctaaaaag aagaaaaaaa tattttgagc taaagcgcat atcaccgttc 3492541 ctatgataaa aatcataagc ccggccaata agctcagttc tctggagtat ttatcgccta 3492601 atggaaccaa aagcggcgca ccgataaaaa tcataacgcc gtaaatactg atagataacg 3492661 caaggacgct gacatctgag ctgaaggctt ttgctaaatc cggcagcagc ggtgagatca 3492721 caagctcttc agatccggct gcaaataccc ccatcgttaa agccagtgcc aacaataacg 3492781 gaaaatgatg ttttgttttg atgtcattgt tttgattgct gttcattctt tctcaaacac 3492841 ctcttccata atcttcttat cataaagttg tattatagtt tagcattgtt ttttctctat 3492901 ttacaattcg aacgaaatat ttataagttt tattattttc atttaaatcc cattatatat 3492961 ttctatattt cattctaaaa atacatgagg atgtaacacg taaaaaaagc tctccggcct 3493021 cccggagagc tttttctatt gcgcctctgt ctgctttttt tcaatcgttt catgatttat 3493081 acgctttttg atgcttagat gatagtatgc ataacagaaa ataatgatcg gcacaccgca 3493141 gtataagcca attctttgat ccggaatgaa aataaggctg atcaacacgc agccatataa 3493201 acaaaatccg agaatcggga ctagcggata aagcggcgtt ctgaactcca gatcattcac 3493261 atttccgcct tctgccagga aacgcctgcg aaagaaaaat tgcgacgcac aaatggacat 3493321 ccacgcgaca actgtcacca tgcccgagat tgagatacac cataaataca ctgtttctgc 3493381 agccatgaca cttgtcagca gcgaacagcc tgaaatgcct agcgtaatca gcagggcatt 3493441 catcggcacg cctttttttg tcagtctggt gagaaaggag ggacccattt gatttgatga 3493501 aagtgaccac atcatacgcg acgccgcata caatcccgaa ttagcaacag ataaaatggc 3493561 cgttaagatg acaaagttca tgatatctgc cgaaaatggg atgccgattt gatcgagtac 3493621 tgctacaaac gggctttcaa tcacccccgc cgttttgtac ggaaggatgg caaccaagac 3493681 gaacatagcg agcacaaaga aaaacagcgt gcgccaaata acatttcgaa tggactttgg 3493741 cagtgttttt tccgggcttt cactttcccc tgccgcaatg ccgacaagct ccgttccctg 3493801 gaacgagaag tttaccatga ccagcgtaaa cataacggcc agcaccccat tagggaaaag 3493861 ccctctatca gtcataaagt tagacaaaaa gggtgtctcc tgtccgcctt taaagtcaat 3493921 caagccaaac acagcggctc cgccaatcac aataaataat atgatcgccg ccactttgat 3493981 gcttgaaaac caaaattcca tttccgcaaa gcttctgaca gagagcgcat taatcaaaaa 3494041 gatgacgatg ccgaacacga ggcaccatat ccagatcgga acggagggca gccacctttg 3494101 catcaaaatg cctgctgacg tcagctctaa ccctactgta ttggcccagc tgaaccaata 3494161 cagccagcca atcataaagc ctgtcgactg tcccagaaat ttagtggcgt aggcctgaaa 3494221 cgatccggcc accggcatgg caacagccaa ttctcctaaa caaagcatga cgagatacat 3494281 taaaaatccg ccgatgatat acgcggcaat ggcgccgagc ggtcccgcct ggctaatggt 3494341 aaagccagag cctagaaaca gcccagtgcc aatcacccct cccaaagcaa tcataaacaa 3494401 atgcctgctt ttcatgctgc gctgcaattc atttttatga ttctgcatca tccttccccc 3494461 tttggttctt ttgccgtgat ggtcatccgg tagctttgca aaagatgaac ggtggtttgc 3494521 tgtatgagga gaggcaatac atgaaatgtg tacggtttat agactcgttc tgtccattta 3494581 tggccgtctt ttccgtacac gcccatatta atggatggaa tattcagctt gcgtatgtct 3494641 ttgaacggaa tggtcccaat catattccac ccagggaagt tcctgataaa agaatcaatt 3494701 tcgccatcgg tttcgtgcag tgataaaaaa ctgccgtctg ccaagtaggg gaaaaacttt 3494761 ttgaagacaa atgtttcgcc tgtcgattca gcggttttgt cagccgcttc tttaatcaca 3494821 tgctgcaaaa gctgatctct tgcgctatct tctttcaaat agttatgcgg caggtaagga 3494881 ggtgcgtaaa atagaatgac ttttgcgcct tgatcggggt caagcttttg aagctcttcg 3494941 attgcctgaa agcatctcat gcgaagttca aggtgctcgt tggctttgaa tgtctgctcg 3495001 atacactgct cgggatctat tccccggttt ctcagctttt ctaagtattg ctccaggcta 3495061 tacacttgaa tgccccatga taaatgtttc tttggcaggt tggctctttt tacatattct 3495121 tcgtaataat ctgataattt ttgttctgtc tcccggcatg cttcctcagt gacttcaata 3495181 agcaaatcca tcatttcttt tgctgttctt tcataaataa aacaattgaa atacaagctg 3495241 gtgctgacag ccgtttgcac attataggat tccttgttat cacgctgata caaacaggat 3495301 gggggcagaa ccaactcccc ttcaaccttt tctgccagat ggatgttatt gtggagacgg 3495361 cttgtgattt cagatgaaat gaaatttggg tcaatccctg ccagtgtatc gccaacatgg 3495421 acttcacgcc cgtaaatgta aaagcaaggc aacagttttc ccgcggctcc ggtatagata 3495481 tatcttgtct gatcaccatc gtaaagcggg gtaataaaat ccgtattaat agcagccaaa 3495541 tagtgaagct gtttttcttt ttttagccgg ttcagctctg aaatgctggc gagaatgccc 3495601 gaatgctggc tctcctcatc gggattggcc ataaacaata catttcccgg caacgtctca 3495661 aggttctccg aaaaatgcag gagattggct aaatgcacgg cgatgccgct ttgcatatcg 3495721 acagatcctc ttccgaacat ccactcgcct gatttggcat cccgctgaac atcctgatcg 3495781 aactcatagc ggctgaaata ctcggccaat ttctcacaat caaaagcgat atcctttaaa 3495841 gggccgaaat cttcaattcc aactgtatcc agatgggcat ggtaaatgac tgtatttcgg 3495901 ctttctccat gtcctttaat aaacgcaaaa atatttttgc gtttgtatgg gtcattggga 3495961 atggcctgtt cccacacatg actggggttt tcctgaaaat aaggatagct cgtgatcact 3496021 tctttgatga aatctgcttt tgtcccttct ccaacggtgc cgttcacgct gctgaggctg 3496081 accagagatg ctgtcagcgc ctccactctt tcagccggat tcatgtgact gatttttgta 3496141 tactgcataa attgtcctcc tgatcaaaaa gttgaaatcg tgcgatccgc taaagaatcg 3496201 cacgatttta tttctctcaa atcaaaaagc ttcggacgtt gttttggctt gcatatgaag 3496261 aattaagtaa tcgggaccgc ctgcttttga gtctgttcct gacatattaa aaccgccgaa 3496321 cggctgatag ccgacaattg ctccggtaca tcctctgtta aaatataggt ttccgacatg 3496381 gaaatcctcg cgcgcccgtt caatgtgcgc acggtttttc gtcagaagcg cacctgttaa 3496441 tccgtattcc gtgttattgg caatctccag catatgatcg aaatcacgcg ctttgcaaat 3496501 cgcaacaacc gggccgaaaa tttcttcctg catcaagcgg gcgttttcat caacatctgc 3496561 aaagatcgtc ggctgaataa agtagccttt tgaatcatcg ccttctccgc cggccaatag 3496621 cttgccttca gatttgccga tttcaatgta tttcatcact ttgttgtagg atgcttcatg 3496681 aatcacggga cccatatacg tatcaggatc ttctggattg ccgacagtca gcgttttggt 3496741 cagcgccaca gctttttcca ccacttcatc atacacatcc tgatgaatga ccgcgcggga 3496801 gcccgcagaa cacttctgtc ctgaatatcc aaatgctgaa tacacgatag aggatgcagc 3496861 aaggtcaaga tcagcgtcct tgtcgacaag cactgtgtct tttccgccca tttctgcaat 3496921 tacccgtttg agccattttt ggcccggctg cactttggca gctcgctcat aaatccggca 3496981 gccgactgca cgggaacctg taaatgagac aaaccgtgtc ttcggatgct caactaagaa 3497041 atcaccgatc tccgcaccat ctcccggaat gtaattcaga acgccgtttg gcagacccgc 3497101 ttcctccatg acctcgacaa attttgctgc cactaccggg gctgcgtcag ccggttttaa 3497161 gagaatcgta tttcctgtca caatcgctgc caccgctgtt cccgccataa tcgcgagcgg 3497221 gaagttaaat ggagaaatga cgatgccgac gccaagcgct tcgtaatgat attgattgac 3497281 ctcgccagca cggctcttca ccggagcccc ttccttgagc tttaacattt ggcgcgcgta 3497341 gaactctaaa aagtctatcg cttcagccgt gtccgcatct gcttccttcc acggttttcc 3497401 tgcttccttc acaagatagc ttgaaaattc atgctttctt ctgcgcaaaa tagccgctgc 3497461 cttaaagaga atatttgcgc ggtgctccgg tctttgtttt ttccaggaat caaatgcctg 3497521 caatgcggct tgcatcgctt tttcagcaag ctcttgatcc gctgtagacg cgtacccaat 3497581 gatctcttct ttatttgccg ggttaataga aatgattttg cggtccgttt caattttttc 3497641 tccatttatg acaagcggat aatgcttgcc gagctgagtg tttacaaagg ccaatgactc 3497701 cccaaatgca gttttattct ttgcttccgt aaaatcggta aatggttcgt gcgcgtatgt 3497761 gactgtcata tgtagtcccc ctcgtgttat gaaatatatc ttcgcatatg aataaaaatg 3497821 caagaatcat gccattttct tgtcttttgc tgaaaaaact tgttgaatcg aacagaaatt 3497881 tgtctaacag gtgatcacct ttctcttttt ccgatcttga acgcaaattt attttgcgtt 3497941 ttttgctctt tacgcaaaaa acaaatgcaa aattattttg cggaggcttc tcaaattaga 3498001 cccatccgcg gaaacgcgat gcttctgccg attttctgat gcccgtcatg taagccgcca 3498061 aacgcatatc cactttatgt gttgccgctg tttgataaat tgtttcgaac gagctgacca 3498121 tgacgcttct cagtttttct gcaacctctt cttccgacca ataatatcct tggttgtttt 3498181 gcacccattc aaaataagaa accgtgacgc cgccggcact cgctaggata tccggcacaa 3498241 gcagcacgcc tctttcattc aggatcttag tggcatcaat ggttgtcggg ccgttcgccg 3498301 cttcaacgac gattgacgcc tgaatgttat gtgcgttttt ggctgtgatt tgattggaga 3498361 tcgcggcagg cactaaaata tcgcaatcct tttcaagcag ctcctcattt gtgatgacgt 3498421 cagtaaataa attggtgacc ataccaaagc tgtcccgttt atcgagcaaa taagggatat 3498481 caaggccgtc tgggttgtag agcccgccat tggcatcaga aatcccgatc accttcgcgc 3498541 ccgcatcgtg catgaatttg gccaggaagc tacccgcgtt tccaaagccc tgtatgatga 3498601 tgcgcgcgtt ttgcagcttg atcccttttt tcttcaccgc ctcttcaata caaatcgtga 3498661 cgccctgtgc cgtcgctgtt tcccgtcctt gcgatcctcc caaaacaagc ggtttacctg 3498721 taataaagcc cggagaatcg aattcccgca gccggctgta ctcatccatc atccacgcca 3498781 taatctgcga attggtgtac acatcgggag ctggaatatc ctttgtcgga ccgacgatct 3498841 ggctgatggc acggacatac cccctgctca gcctttccag ttctccaaat gacattgtcc 3498901 gcggatcaca aataataccg cccttcccgc cgccgtaagg aagattggca atcccgcatt 3498961 tgagcgtcat ccaaatggat aatgccttta cttcctcttc attaacttct ggatggaagc 3499021 gaacgccccc ctttgtcgga ccgacagcat cattgtgctg tgaccggtag cctgtgaaca 3499081 ctttgacgct cccattgtcc attttgaccg gaatgcggac agtgagcatt ctctgcggct 3499141 ctttcatgag ttcatacata tctcccggat aacccagctt ccgaagggct tccttaatga 3499201 ttgtttgggt agacagaaat aagttaagag cttctttttc ttcatctttc gagacttgct 3499261 ttgctgacat ctttttcacc tcattgtttt tttggccggc tgtaatgtaa gcgctttaaa 3499321 aaatcagccc gccaattcct ttcttcattg gattcaccct tatcatcatg caagatccgt 3499381 accagctttt gaatccacaa aaaaagagac tgaaaacatc tcagtctctg actacaaatc 3499441 tatcgattaa cggggatcaa tcaccagctg cgtttcagca taaaaactgc cgattcccaa 3499501 accgtttact acatcgcctt taatcgtgta agtgcctgcg cgaggaagag ttttacgcac 3499561 catgacaagg tcaaattcgg atgcgcctaa caaatcaagc gtaagcggga gtctgactgt 3499621 ttttccatcg tttaaaatct gtgtttcttt cagtgttctt ccattcactg aatctcttgt 3499681 cgtagcatga aacccgtcag gaaattgaaa ttctaccgct ccaagagaaa gcaccgcatt 3499741 tggtttatat gtcacttcaa tatcagaaat ggtccactct ttcgtgctgt taactgtttt 3499801 tgcctcgatt gatgcagact gtgcatgagc ttggcccgaa ggaagtaaga ttgatagtaa 3499861 aacagctgaa ctgatgaata atgaagatac gaatgaagtt ctttttagca tgacatttcc 3499921 ccctaattga ttgttgaaat ttggccagag cgtcctctgc agaaaaagcg ctttttcata 3499981 attcgcgaat taccagttct ttttcttaaa aattaatcta tcatcatttt ccatggaagt 3500041 aaatgttttt taaggaatat taacacttgg aattcaatga gaattccttc ctgtttatac 3500101 aaggttcaaa tggacgattt ccctctcttt ttctagtaac atctgcctga cattttatat 3500161 cttttatcct attttaaaaa agggcaaaaa aagtcgaaga tgcctctgct cttcgattga 3500221 tcacgttcct atttttatct gaattcagtg ttccagttaa aaccgatcgt ctcatcatcc 3500281 cacggaattc ttttttcatc aggctgatcc gggttatacg acatggtggt aaaatagata 3500341 attgtcagcg gcgtctctcc cagcactcta tatccgtgag ccaccccttt tgggattaat 3500401 aacagcatcg ggttgtcttc gcccatataa tagacgtccg tttctccttt tgtctttgaa 3500461 tcctctcgaa gatcgtatag gacaacctga gcgtggccgg ttgggaagaa ccagagatca 3500521 tcctgcttct catgataatg aaatgcctta atcacacccg gatagctttt cgaccaagag 3500581 gcctgcccaa aatgctcaag gagattctca tcgtcccgga ccagctcagc aaaaaagcct 3500641 ctgtcatcgc tatgcttcat caattttttc accttgactc catcaatcac acgcactgct 3500701 cctttcctgc aaatactctc gtaacgcttc ccgccagtgg cgggggcgga tgccggcttc 3500761 ttcaatagcc cgatggctca gcacagagta tgccggacgg ggcgttttgt tcccgtattc 3500821 ctctgtcgtt acagacaaaa tggctgtttc cagcccgctt tcttccataa ttgccgtcgc 3500881 aaactcatac cagctgcata tgcctgaatt gctgacatga tagatgcccg gcggatggct 3500941 gaacagcttg atgaccgctt ctgctaaatc cttcgtataa gtcggcgaac caatttgatc 3501001 gctgacaacc cgaagctctt gtttcgtttc agcaagtttc agcatggttt caacgaaatt 3501061 actgccgcca tgtccgtaca cccacgatgt cctgatgatc gtgctgtctt ttgtcgttaa 3501121 tcgtatcagt tcttctccga gccttttgct tttgccataa atggttttcg gatcgagggg 3501181 atcgtcttcc ctatatggct gggttccttt cccattgaat acatagtccg tgctgatatg 3501241 aacatattga gctccgatgc gggttgactc aagcgctgta taataagcgc cgattccgtt 3501301 aatcaagtac gctttatcaa gctctttctc gcattgatca accgacgtaa acgcggcgct 3501361 attgaccacg atatccggct gataatggcc aaacgaatgc cgtactgagc gctggtcagc 3501421 aatgttcatc atcttctttg ttaacgcaat gacctcatat ccggcttgct tcagctggcg 3501481 gcatagttcc aagccaagct gtcctcccgc cccagtcacc aatacctttg tcaatcagat 3501541 caccttctca tcggtcattg tctgtatacc actgaatcgt acgcgcaatg ccttcttcaa 3501601 acgtcacttc ctgccgccag cccagttcgt ttttcagctt tgatgcattg atcgcatagc 3501661 gccggtcatg cccttttcgg tcttccacgt gggcgaacaa ttcctcacag cccagatgct 3501721 tcaaaatgac actcgccagc tctttattcg tgcgttcatt tccgccgccg atgttataca 3501781 cctcgccgtc ggtccctttt tctaaaatca gcttgatcgc gcggcaatga tcctccgcaa 3501841 acagccagtc tcggatctgg agtccatcgc catacagcgg aacaggcagg ccctgcttcg 3501901 catgacggat aatcgtcgga atcatttttt cgctgtgctg ataaggtccg taattgttgc 3501961 tgcatcgtgt aatgatggcc ggaagcttgt gggttttcac ataagacaac acgagcaaat 3502021 cagagcttgc tttgctggct gagtatgggt tattaggaga aagcggcgtc gtttctgtaa 3502081 acgcgggatc atccgctttt aaatccccgt atacctcatc tgttgaaata tgaatcagct 3502141 tcttggcttt tcctttcaag accgcttccg ccaatcggta tgtccccatg acatttgtgg 3502201 tgataaacgg ctccgcttgg gaaatgcttc tgtccacatg cgattctgct gcgaagtgaa 3502261 tgacgccatc gtaggtctcg tcaaaagcgc ggtcgatatc ctcctgaacg ctgatgtccc 3502321 cttttacaaa gcgaaaacgg ctgttttgct ttaatttttc catttcctcc gggtggctgg 3502381 cgtacgtcag tttatctaaa acggtaatgc gcgcatccgt ttccctcagc atgagctttg 3502441 taaacgtgag cccgatgaag ccggccccgc ctgtaattaa atatgatttt gccatcactt 3502501 ttcgtcctgt cctttccgta aagcctggtg tacaagctgg gaagcgagat aaagcgattc 3502561 gtgagttccg gcatctaccc accagcctga taacacatca tacgtaagct ggctgttttc 3502621 gatgtataga ttattcacat cggtgatttc cagctcgccg cgctttgatg gtgatatttg 3502681 ttcaatatat gaaaacacct ctgcatcata catataaatg ccggtaacac aaaggttggt 3502741 cggtggctgt tcgggctttt cgatgatgga acgaatccgc ttgtttttct catcaatctc 3502801 agcaatcccg aaacgttccg ggtcatcaac ttctttcaga agcacttttg ctcctttccc 3502861 ctgctgttca aagcgttctg tataaggctt taatgaatct tcaaatatat tatcacctaa 3502921 taataaaatg aaagactctt ttttcgtaaa gcgctttgca taagacagcc catccgaaat 3502981 gcccgatgct gccggctgta cttgataagt gatagtaacg ccaagctctt ccccgttccc 3503041 aagcagtttg taaaattgcg gcatatgctc cttttggctg atgagtaaaa tgtcttttat 3503101 tccggcttcc tgcagcttca taatcgacca gtatatcatc ggatacgggc ctacaggaag 3503161 caaatgcttg ttgacggctt tcgttaaggg cataaggcgt gagccgtttc ctccggctaa 3503221 aataacacct ttcacattaa cacttcctta catgcatttt tatatctctt gttcatataa 3503281 atcttgaaga atagctgtta cccgtataat gcctttgcca tccacgagcg gccttcctcc 3503341 cttgtgcaaa gaaaggcgaa gaggatagct gctcataatg cgtgacatct gatagatgag 3503401 tgtttcatcc ggtacaagct cacccaatcc aagatcaaga gcggcgcctt ggtcagcaaa 3503461 tgttttggct gtagccgttt gatgctcaac ctgagaaaga acaaggcacg gcacgccgat 3503521 gcaaatggct tcatatagag agatgccgcc agcgacaatg gctgcgtccg cttgtttcat 3503581 caaacctgcc atatcatttg tctgttcgat catcttgtac tgcggcttct tttcgatccg 3503641 ccttcggact gcctcttgat gcggtgaagc gctccccatc acaaacatca tgtttttgtc 3503701 ttttatgtcg gggacttgat cagcggcagc cagcacttta aaaataagct gcttcggatc 3503761 acttcctcct aatgcaacaa ggatattgcg gcagtctttc ttaagtgtgt aatcctctct 3503821 tgcggcctga aaggcggggt gaagaataag atagtccgga ccttcataga tgcgtgtgtt 3503881 tccctgaacg tacaccctgc ttctgatgtc accgtaaatt ccgttaatga ctgcgtcact 3503941 atattgaatc gatttaccgt ttttctcttc aaaaagaaca attttcgcat ctgtctccgt 3504001 ctttattttc tttaacagct ctgcaggcgc gcctagaata tcaaacaaaa gcaaatcaag 3504061 cttcttgctt tttatttccc ggagaataaa ttcgtgctgc tgcagctccg gctttacgat 3504121 gacctgccaa tgctcttcat gaagaaacgc ttcagaatcc tgattcgtat aaaacgtaat 3504181 caagcatcgc tgtttgagcc cctccgcaag cctcttcatc cggacaacat ggcccattcc 3504241 cttttcatag ccgccgtctg cgaagatccc aacatgcatg gctagtcagc ctctcgttcg 3504301 gttgccgcat cggggttccg gttcagaagg gtgataagct ctgaggcgga tacatcgggg 3504361 cgctcgcctg ctttttgata gagggccttt atcgattcat agtcttcctt tgtatcaatg 3504421 gtcagccgat attgaggggc gcgaaatcgt tccggcgcct ctaaaaactg aacacgataa 3504481 agagctggat gattccttat atataacgtg acatgctcct gatattgatc ctccaaagcc 3504541 tgaatacggc tgatgtcaat taacaggttg gcgttgacca cttcgccgca aatccctaat 3504601 ggggcattca ggatatacgt ataatccgag ccttgatcaa aatgcgcctg aatcattaca 3504661 tcgagcagct caggatcgac aaacggatta tcacctgtta accggatgat gactgacggt 3504721 ttaacagctt ctatgacctt cacaaaccta tcgaggacac gttcttcgct cccgcggaaa 3504781 acacgaaagc cttgtttgat acagtgcgcc tctaatatgt cgtcagtttc tttgtcagac 3504841 gtggcgatga caagattatc ccgatccttt tggtaaaacg cgctttgccg gacacggtga 3504901 acgagaatat caagtaaacg attcgatccg agcggccgaa gcacttttcc cggaagcctt 3504961 gttgaaccca ttcttgcttg aatgataaag agaatatcat tcatgaaacg ggctgtcctt 3505021 cagtaaaatg tcatcccaga caatgcctgt gtcggctgga atgtctctta cagcccgaac 3505081 accgctggtc agcagttcaa aaaatctcgg gtgcagcccc tgcggctttt gtccgggccg 3505141 aagcactgcg atattgtctt cactaaaggc ttcacctttt tgaatcggag ctgttgtaaa 3505201 aatgcctctg tatgcaaagt ttctgatttc tccttcgatg gcggtcgttg ttttgtatga 3505261 actgccaagc agtttttcag agaccggctt tgtgatcccc tgtttcagct cagcttccgt 3505321 tttcctgatg ccatcgacca tttctttcaa ttcatccgga tttaatgcaa acgagtggtc 3505381 agcacccggc agatttttat cgatcgtaaa atgcttttct atcagttttg ctccgagccg 3505441 aaccgcggca cacggcgctt ctgtcggatg ctcgctatga tcggagaagc cgattaccgc 3505501 ctcaggaaaa gcggcggcaa gcatcggaat gacgctgagg ttgctgtact ccggcggtgc 3505561 tgggtatttc gccacacaat gcattatggc aatttgattg tttccctctg ccctgatggt 3505621 gcgccaagct tcgtgaacat cagagatttc agctccggct gtcgagaaaa tcatcggcct 3505681 gttcagccgg gcgacatatt taagcagcgg gagatggtta atttcatagg atgcgatttt 3505741 aaaagcgctc ggcgaggtag actgaagcag atcagctgac ccctcgtcac ataccgtact 3505801 taaaaagatc acctgctttt cgcggcagta atccaatagc ggtaaaatcc actcagcagg 3505861 catttccata gattgaacca aagaaaaaat agagacgtcc ttgcccgctg ccgtcttgta 3505921 caaaccagga tctttctggt acatcctatc agcttggaac atttgaaatt tcacggcatc 3505981 cgctcccgct tccgccgcgg cgtctatcag cgcaaaagcc tgatcaagct tcccgtcatg 3506041 attaatcccc gcctcagcaa taataaaaac aggagcgtct ttgcctacag ttttattcgc 3506101 gatctgaaac gctgccatta tttcgcctcc ttgcccggcc aaatatgata atagtaatac 3506161 gattgttcag cggtgaagcc cattcgttca taaaggcgga tcgcccttac attgtgaagc 3506221 tgcgtccccg ctgttaccgt tctatgcttc tgggtctccg gttgttctat gagattcgcc 3506281 aataaatgaa acgcaatacg tttcccttca aatcccggct ttacagccat caaatcgaga 3506341 atgcactcat catctcttga taagccctga agatagccga tgacctcgcc attgtgttta 3506401 gcgacaatat tgaccgccgc ccttccattc agattgtttc gtgtccactc ctgaaatatt 3506461 tcgtttgctg catcgcggct gagatgagga tcctgaaaat atctgctttt tgtaaacgag 3506521 tctcgggcca gctcacatat cgcttctgtg tctccgggct caggcgggcc cagttcaaaa 3506581 aatggcggtg ttttgtcata aaaagacgga ggcatcgcca gcttcagcaa actcccgaca 3506641 aagtaagagg atggctgctg ttgtatcaca tgcgcggctc cgatatcttc agccggaaca 3506701 cggacaaaga taaaatccgt ttcatccatt tggcgtacag tataaaaagc ttcaaacagc 3506761 ctctttagct gcccggtact atttgccgca agaagtttga cgttcatgac tttcttctga 3506821 agcaccttgc tttcccacaa agaatcttcg taaagcaata cgccttggag cctgctgttt 3506881 tcaaaaaggc cgagggaaaa ttgatacgga acatccaatg taagctttct gctttggaga 3506941 aattcctcaa ttgcctcttt ggagacattt tcttttaccg tatacactta atcagcccct 3507001 tttacgatat cccgcacagc ttcaatgaca tcatctacat catcgtcaga cattgatgga 3507061 tagagcggga gagaaagggt tcgtttatag taattcatgg cattcggaaa gtccgcttcc 3507121 ttatatccaa attgcttttg ataatacgga tgaatgtgta ctggaataaa atgaacgcta 3507181 gtgccgatat tgtattcatc ctttaaagcc gtaatcattt cgctgcgcgt aaccccggcc 3507241 tttttttcat caacttgcag aacatataga tgccaggcgt gcctgccgtc atcatggaca 3507301 aacggcgtga tcagcccagg aatctgctga aaagcggttt gatagcggcc ggcaatctct 3507361 tctctccgtt tctgcatatc atccagccgt ttcagctgat gaagtccgag ggccgcctgc 3507421 aaatcaaaca tattcatctt atagccgggc gattcgactt catagtacca gctgccattt 3507481 gaagaataac ggttccatgc ggctttactc atgccgtgaa ggcttagcac ccgtatctta 3507541 tcggcaagct cctcatcatc agtcgtcagc atgccgcctt cccctgtcgc gaggtttttg 3507601 gtggcgtaaa agctgaatgc cgttgcatcc ccgatagaac cgatcattct ttgcttataa 3507661 gtcgtatata ccgcatgtgc cgcatcctcc agcacgaata aaccatgatt ttgggcaaca 3507721 gccaatattg catccatatc gcaggactgc ccgccaaagt ggacgggcac aactgctttc 3507781 gttcgcggtg tgacggccgc ctcaagcttt accgggtcaa tattgagcgt gttttcgtca 3507841 atatccgcaa acacaggcgt cgctcccgta tgaataatcg tattggcggt cgagctgaac 3507901 gtaagcggag aggtaatgac ctcgtccccg ggcccaatcc cttttgcttt caaagccaaa 3507961 aataaagctg cggtacatga attcaccgcc acggcgtgct tcgccccgac aaacgcggca 3508021 aactcttttt caaactgctg aaccttcggg cctttagaga gccatcccga ttcaagcgtt 3508081 tctgtaacct cctgaatttc ttccttaccg attaacggca atgagtaagg gagaaaatga 3508141 tttctctttt gcaccatttc tttgcgctcc tatcatttta ttcagtatct tcccgcctgt 3508201 aatcaacccc tgttttggct ttcagttccg caaataaagc atttgttgat tctgccaccg 3508261 gataattagc cgctatgaat gccaggcgcg cctcttctgc tttttgatgc acgtcgggac 3508321 ttcgaagaac ctcaaccaag gtgtgcgcca gttcatccgg ctggtcaaac ataaaatcgc 3508381 caagagactc ataatacgga tacgagcgat ttccggacga ttttcctatc agcacaggct 3508441 tttgaaacag catggcttca agaccgactg tcgaggtttg cgtcactgcg gcatcaacat 3508501 acggcagcaa atcataaagc tccagctcct ttttgatgac tctgcatgct tgatgttttt 3508561 tcgccgcctc gtgatacaga tcaagcttgt tttttccgat ttcccacggg tggggtttga 3508621 taatgatttg cagctgcttc tgatcagaaa gcccctgcag cacaccggaa taaaagtctt 3508681 ctgaaaaggg ctgagtggca atgagcacaa tttttttagt cggctgaaaa gcaagttttc 3508741 gatagaatat ggacatatcc ataggcgttc tgttaaaaat ctgatcgaag cggggatgtc 3508801 ccgttacgag aatctgctcg ggtttacagc cttttcgtat gaaccactct gcttcatacg 3508861 caccaaaaac agcttgatag gttgtaaaaa caggaatgaa ggcttcatct cccatcaatg 3508921 cgccatgctg aagacaaatg ctgacggccc cttttctttg acacatgaga gcgagcaccc 3508981 tgctgtaaat gtcttctgcc gttccgacaa taacagctga aatcttttcc tgttcaaaca 3509041 gcgcatcaac tgtatcaatg gcctctataa ataaaggaat atctttgaaa agccggtcgc 3509101 gaaacgcttg atcaccaaat gccgggtgat catcataagg ggcgagaagc gaacaggctg 3509161 tttcgagata ctgcttcgaa tcgccttttt ggcatgaatc cgcaatctcc cgcttgctaa 3509221 ttacaggcag atcacaataa tgcggcaaac tccatctggc caaaacagcc gttttttcag 3509281 gatcaaattg atagtaattt tcgtttgaaa aacgcaggta atcaaagtgc aaaatgactt 3509341 tccctttaac aggttcgtca tttgttttaa cgatgttttg gattctttct tcaaaaaacg 3509401 gctgaatctg tccctcatcg atatgctgat ccaccgatcc gaataattcc ggttcttctt 3509461 ccatcatcac cctcagttca gggctgatgt attgataaaa attactgata agcccaagcg 3509521 gaatcccttt gtagcgaagt ttgtcaaaaa gctccacgta cttccggtac agcacccaat 3509581 aattgcttaa ataggccgac aagctctcac cccattccaa gcttttttaa tgattcacgc 3509641 agctctcggc aatttcgctg cggaggaagg ttcctgacaa attcattttt ttctaattca 3509701 aacagctgaa agtgaatcga ttggtcggta atataattca ggtccagctc ctcatccagt 3509761 gggtaaaacg gataaaaatg attgactctc caaaagaacc gggcatctcc tatacggtaa 3509821 aacgccgggc tttcatccca ataggagcca aacttctcct ttaccttctc aagcaccgaa 3509881 tacctgtgca tcaccgagca atgatcaatt gcgcacggcg cgttccatgt cacttgagcg 3509941 gcaggcctga cagtttcttt tacaatgtca cgattctcgt ttaaatgata ggttttggag 3510001 gctgagtaaa tcacagcctt ttcaggatgg gtatcgagct cccgcaccat tttcaggagg 3510061 cggtccggca tatagatgtt gtcatccgtc gcataggtga tatattcacc ctccgccatc 3510121 tcaatcgcct gattgatcag tgccgcgtat ctcgtttttt ctgttctttc cttcactcca 3510181 gatatatcgc tttgataaaa acgcactcgg ttatcattca aaaaaggacg gattacattc 3510241 agcgtctctt cattggagtt gtcatccata ataaacaatt caaaatctga aaacgtttgt 3510301 gagagtatgc tagaaatgga ctttgccaca taatcgcttt tgttatagct cgtcataatg 3510361 actgatactt taggcaaatc ctacacctcc ttcttggaac ttcacacctg aaactatcgt 3510421 tatcttatgt tgcttatgct caagttgcgc tagggataca aaccaatatg cgaaaagttt 3510481 gtgtatgttt ctgaaaaaca gcggctgccc agagcgaaat ctgatcggtc cgctgttctt 3510541 tttcagcata atccaagcat cagcctcata aggtgaaaga gataaaaatc gcaccagcga 3510601 ctaagatcgt tttccatcgg aggtgagtca tcgcggagcg ttcacctata catccagaac 3510661 atgttttgaa tggttttcat aaaaaggagg aacgatatga aaccgaaaaa aaatcaatat 3510721 cagcaaatgc aggcatttga taatatgcag gggtatcagc ctcagtttgg cgccaacccg 3510781 tacccgcagc aaggccaagg ctcacaaatg cagacaatgg ggatgcagcc aatgatgcca 3510841 atgcagcagg gacagcaagg acaacaagga cagcagggat ttggattccc gggccagcag 3510901 cagggcggcg gttttcaaat tccatcgggg cctacaccgt caggaccggg ccaaagcgtt 3510961 cccggcatgc tgcctgttga ggaatcttac atcgagaata ttttgcgcct gaatcgggga 3511021 aaaacggcca ccatttatat gacatttgaa aacagcaagg aatggggctc gaagattttt 3511081 cgcggcgtca tcgaagctgc gggccgggat cacattatta tcagcgaccc gaaatcagga 3511141 acacgctacc tgctcctgac aatctacctc gattacatta catttgatga agaaattgct 3511201 tatacgtatc catattccat ggcgtcctat tcgccaagat aagaaaaaag ccaatcactc 3511261 atatgatgag gattggcttt tttgtttata gatatttgac ggctgcgaca acgatcataa 3511321 tccaagaaat aataaacgcc acaccgccga gcggggtgat cgctccaaga atggagattt 3511381 gcgtcacact tagaatatat aagcttccgg aaaacagcac aattcccgca aacatcagcc 3511441 agccggctgt cgtgacactg cctatgccgg ataatttatc agccagaaac gcgacaacga 3511501 ataacccaag ggcgtgatac atatgatact gcacgcctgt gtgccaaacc tgaagatact 3511561 tatcaggtat tttcccttct aatccgtgag cgccgaatgc tccgagtccc acggcaagca 3511621 gggcgttaat ggcccctaat atgataaaaa ctttcatcta tctctcccgc cttttcgtta 3511681 aactcatatc atttatctta tcgcacctgc accaaaattc aatgtttgtt ctccgttgac 3511741 acgagattgt cggattttct cctgcgccaa agctggaact ggtcagctgc tattgcagca 3511801 agcgtcccta atacgagccc gttgcttaat agagaaataa ataccggatg caatcccttt 3511861 aacgcagttt caggaacaaa catgataccg acccctgtca gcagtgagat accgatgata 3511921 gacctcaccc tttttgattc ttctttctca tatgaatcaa attcggcaaa ggccagaccg 3511981 cccattgcgg agaacacaac aaaattcacc gcaaatccaa cgggtgacgg caggctcgca 3512041 aacgtattca taaaaaacgg gatcacgctg atcacgataa ccagaatact gccgagcata 3512101 aacggttttt tagaaggcat cttggtcgtt tcaataaaac ctgcggctcc cgaaatcgga 3512161 acaggcgcaa tagctcccgt caaaccgcta agcagatggc tgaatgaagc tgcaaaaccg 3512221 gcatggcgtt catgatgctt tccatcaggc tgtttgctga attttttcat ggcgatgtcc 3512281 acgaccttca tgctcgccag catattcacg atcagcaaga tggtaataaa aatagaagtg 3512341 atgatcaggc cgctgttaaa taacggggtc ccaaaaggaa acagggaagg cagctgaaac 3512401 agccggtccg gcatttcaat cggctttgcg gctccggcag ccgcaaacag cacccacccg 3512461 ccgaacaagg ctaataaaat agaatattgc ttaaaaaaca tgatgttcga atttgtcatt 3512521 ataaaagcgg cagcgatcac aacaagcgcc aggccaaata caagaccgtc caccccgtcc 3512581 tgtcgataac cgattccgag aattcctttt ataatgggct gactcagctg catgacaaga 3512641 agcaataaat agacgcccgt tacaaccgga gtaaacaatt ttgcaagtct gtcaatgacc 3512701 ttgaaaacac ttaacaaaaa gaaacataca gcgcttacaa gaagagctcc ctgcaaaccc 3512761 cgcagtgtgt ctccatatgt cgcaaacaca gttcccgtca gccctgcgta aatcgtatac 3512821 actccccacc acaagccggc tgggctttca ttgatcggca gtctgtggcc tttcaaacac 3512881 tgaatgacgg cggcaattcc cagtacaaaa aaagtgcttt gaatcaatct tgcagaatct 3512941 gagtgatcca gatgaaacga ctgggcaacc gccaccggaa caacaatcgc cgcagcaata 3513001 ataaacgctg tccattgcag cgcgccaaga accaatttca cgtaagctca acctctctct 3513061 ttaaaaatca aataaagact ctccgtttcc atcctcttcc tgcttctctt tttcttgctt 3513121 tcgatatttg tttaatcccg cgctccccat cattttttcc atcatcagct ggtctgtcga 3513181 tggcggcgcg gcgggacttg gcgtaacgct cggctgtatg cggggcgcgc tcgcgttctc 3513241 cggctgatca agcacgacat cacacagaga acggacaacc gctacataac gcttcagctc 3513301 ctcatcccgt tcagccgttt ttgctttttt tagctcttct tccatctttt gaatcaaagc 3513361 agatatatga atgttcatga agcaccctcc aaaaaaataa atgttgtctt cctgcatttt 3513421 atcaaattcc tgctgaaaac gcagatatga gtttgttatt ttttctgaca aaccttgcgc 3513481 gattgacaag cagaagagat ttttcacata ataaatcacc ataccttaca aaaaggagaa 3513541 acggaatgaa cagcatcccc tctatcatca gcaagcataa agcctatttt gcggcgggac 3513601 atacgagacc gcttgaatcg agactgaaca ttttgcgaaa gctgaaacaa gccgtcagaa 3513661 ctcatgaagc cgatctcata gccgctctct accaggatct ccataaatcc gagcaagaag 3513721 catactcaac agaaatcgga atcgtcttgg aggaaatcag ctttgtcatg aaacggctga 3513781 gaaaatggtc caagccgaaa cgagtcaaaa cgccgttgac tcatctaggc tccaaaagca 3513841 tcatcatccc tgagccgtat ggaaccgttt tggtgattgc gccttggaac tatcccttgc 3513901 agctggcgct ttctccgttg attggcgcca ttgcggcggg gaacacggtc gttctcaagc 3513961 catcagaata tacgccggct gtttctgcta ttctttccaa actcatcagc agcgtttttc 3514021 caactgatta tgtcgctatg gcagaaggcg ggcccgatgt cagcacagca ttattacagc 3514081 agccctttga ctacattttc tttaccggca gtgtagctgt aggaaaaatc gtcatggagg 3514141 ccgccgccaa acaattaatt cccgtaacct tggagctcgg cggcaaaagt ccctgcatcg 3514201 tccataaaga tgctgacatt cagcttgccg ccaaacgcat cgtcttcggg aaatttacaa 3514261 atgcgggaca aacctgcatc gcaccggatt atttatttgt ccacgaggac atcaaaacga 3514321 agctcacaga agaaatgaag cgtgcgatca gagaatttta cggccctcag ccggaacgga 3514381 atccacagta cggcaaaatc gtcagtgagc gccactatca gcggctgctc agctttctga 3514441 atgatggcat cccgctcaca ggcggacaat ctgatcccaa tcatcacaaa attgcgccga 3514501 ccattctcga acaagtgaga gatgactctc cagtgatgca ggaggagatt ttcgggccga 3514561 ttcttccgct ctttacatac cgcaatatcg gggaagtcat tgagaaagtc caatcgcgcc 3514621 ctaagccgct cgccctgtat ctcttcacca caaacaaaga aattgagcgc gctgttttag 3514681 gaaatctgtc gtttggcggg ggctgtgtca atgatacgtt aatgcatgtt gcgacgccgt 3514741 atttgccatt cggcggcgtc ggggaaagcg gcatcggcag ctatcacggg tttgacagtt 3514801 ttaacacatt cacgcacaaa aaaagcgtcg tcaaacaaac gaaccgtttc gacttcgcat 3514861 ttcgttatcc ttcctccaaa aacgggctgc gaatgattcg aaaaatactc aaataaaaaa 3514921 gcgcagatca cctgcgcttt ttacaaatcc ttaatacacc aatcaatcgg cgcctctccc 3514981 attttctcca aataggcatt cgcccgggaa aacggtctgc tcccgaaaaa tccgtttctc 3515041 gcagaaaacg ggctgggatg cgtcgattca atgataaaat gcttggaggt gtcgatccgt 3515101 tcttttttca tttgagcatg ccgtccccac aaaataaaga taaccggccg ctctctttca 3515161 ctcagcacgt caataattcg gtccgtcagt cgctcccagc cttttccctt atgggaattc 3515221 gcctgtccgc gccttactgt cagcacagta ttcagcaaaa gaacgccttg ctttgcccag 3515281 ctcacaagcg acccgtgatt cgggatgctg cacccgatgt cctgctgcag ctcaagaaag 3515341 atatttttta acgaaggcgg ctgctttaca ccgggcttga cagagaagct taaaccttga 3515401 gcctgtcccg gcccgtgata cggatcttga cccaaaatga cgaccttgac atcatcatat 3515461 gatgtataat gcagcgcgtt gaaaatatcc cggctgtccg gataaatcgt ttgctccgcg 3515521 tattccctct tcagcatctc tctgagctct tgataatacg gtttctcaaa ctcttccttt 3515581 agctgattcc accagctgtc ttgtaaaagc tgtttcaaga ttcaggcctc cttacgaacg 3515641 atgaagtctg gaatagacag gctcgccatc ccaaaccatt tcactttttg cttcccgcct 3515701 cttcatctca ggctcttcaa gcaggacggc aaagtttttc gtcggcagct ccccgagtcc 3515761 gtgcttttca cttaaacgat ccaaatattg cttccgcttg gcgccaaggt cagcagactg 3515821 attgtctccc gcgtcactga aggcataaat cacgctggcg caagggacac gcttcacccg 3515881 gtaatccttg gccgcgcgca aataaaaatc ccagtcccag taattgtgca catcagcatc 3515941 gaaatacccg atttcatcat gcagaaaacg tctgtacatg ctgcccgacg gcacgtatgt 3516001 agaaaacact ctcatatcct catagtcagc ggtataagca aacaatttcc gtgacactgg 3516061 ataccttgtt ccgtttttct cttcaaacga aactatttcc gcatcagaat gaacgaagtc 3516121 tgccgtttct atttcctttg ccattttctc gatatgccct ggcgtaaaga aatcatcgtc 3516181 atcacacagc ataatgcaat ccccagacgc ctcttttaca ccggcatttc tcgcagccac 3516241 atgccccgag ttcttttcta aattgatgac agcaatcggc agctccggat aaagtgcttt 3516301 gaccggcacg accgattccc cggcatcatt cacaataata atttcatacg gcatcaaggt 3516361 ctggcgggaa atcgactcca aaagctcaca caaagccgga atccgattat aggtcacaat 3516421 tacgatagaa atcttcatga tgctctcctt ctcattttca tagtcatgta ctattaaaac 3516481 atatattgga cgggagatca gtgggaatat cctactgaaa cggcatacta caatgataga 3516541 aacagcaaag tggctccgat cagaagcacc atgatcagca tcagatctcc aaagacatga 3516601 aagatatctt tcatgcggac gccattcgga aggataagac gccacagctt agattgatag 3516661 accggcagca gcaccagtgc ataagaaaga cacaaaaatg taaaagccgg cggcacaaaa 3516721 gcacagcctg catcgtccca attcatcatg atgtctttca tactagatcc atccaataaa 3516781 aacaaagata tcatgagggc tagcaacaca aaggacccca attgaacctc aaacaggcgc 3516841 attttctggt tatatgcaaa tcggaccgcc caaaaccaga cataagcata tgaacatagc 3516901 agcgtaagaa tggcacctgc tgtaaagacg acatcaggca gccgatcaag cagaaaaaca 3516961 aaaggcaagc tggctgccat agccaagagc atgcagccac cagtaaacaa aaatactgcc 3517021 ccatgagcta caaaaccata taaacaagag ctaatcctca cgacatacac ctcctttaca 3517081 tagaaattct atgtatatac ctaaaaaatc agacaagctg acgcctgcca atataacagc 3517141 ccattcggcc aaataacgga aataacagcg ttgcaaaagc acaagttcca acaaaccaag 3517201 gtgtcaacaa ggattgaaac agcgcagcag gaattacatt gaatagaaaa acaagcataa 3517261 aaatgacgtt tggcaccatt gagatcagaa tcgtatgtag aacaagcttt tctccgcgtt 3517321 ttccaaactc cttcacgcct tgatacccaa tcagcaccca gtagatcata tatgcagcta 3517381 agatcagcca aacagaaaca gaaatgcctt tccatactgc ttgaacaaac ggtgattcaa 3517441 gccatacatg cattattgta atcgcaatgc cgacagcgaa tagggcactg ttacagaaaa 3517501 gatggaacat caaaaacgca cgaaacgtta ctggctgtat tttcttaaac gaagaaacaa 3517561 tgtcagttgg tgttccaaac gcctgcaata aagtctgcat agcttcctcc tcactctttc 3517621 cttcctgaaa agagcgaaac agatgatgtt caatatggct ctcaatctct tctatcatcg 3517681 cctcaccctc aggaagccct ttaagcccgc ttttgatttc ggatacatat gtttctttat 3517741 ccattttgtc cgctccactt cagtattcgg tccatcatgg ctgaaaatac gctccattcc 3517801 ttcgtgcgtt ccgccagcac ttctttgccc tcgtctgtaa tccggtaata tttgcggtcc 3517861 ggtcctttct cctgcttctc ccagtaggaa gaaatatacc cttggcgttc aagcttgtga 3517921 agagaaggat acaaggtccc ttctttcatc tgcagttcat ttccgctgcg gcttcccatt 3517981 tcttttacaa gctcatagcc gtacatcggc cgctcgttca gaagcgtcaa taccaatata 3518041 accgtgcttc ccttaaccag ctcacgattt aacatctcaa aacccctacc tagttttctt 3518101 atgtagcatt ttacgaaagc ccgttgagat tgtcaaatga ttcctataga tcttctatat 3518161 tgtgatacag agaaaatcta actataatga aagacaaaac atgatggagg ttcaagacat 3518221 gtctatgcat aaagcactca ccattgccgg ctcagattcc agcggcggtg ctgggattca 3518281 agctgattta aaaacatttc aagaaaaaaa cgtatacggg atgaccgcct taacggtgat 3518341 cgttgcgatg gacccaaaca acagctggaa ccatcaggta ttcccgatcg atactgatac 3518401 aatccgcgcc cagcttgcaa caattacgga cggcatcggc gtggacgcca tgaaaacagg 3518461 aatgctgcca accgttgaca ttatcgagct tgcggcaaaa acgatcaaag aaaaacaatt 3518521 aaaaaatgtg gtaattgacc cggttatggt ttgcaaaggt gctaatgaag tcctttatcc 3518581 ggagcacgcc caagccctgc gtgagcaatt ggctccgcta gccactgtca ttacgccaaa 3518641 cttgtttgaa gccagccagc tcagcggcat ggatgaacta aaaacagttg acgatatgat 3518701 cgaagccgcg aaaaaaattc acgcactcgg cgctcaatat gtcgtcatta caggcggagg 3518761 caaactcaaa cacgagaaag ccgttgatgt tctctatgac ggagaaacag cggaagtcct 3518821 tgaaagcgaa atgatcgata cgccttatac acatggcgca ggctgtacat tctcagcagc 3518881 cgtgacagcg gagcttgcca aaggtgcgga agtcaaagaa gccatttacg cagcgaaaga 3518941 attcatcaca gcggccatta aagaatcctt cccgctaaac cagtatgttg gtcctacgaa 3519001 gcattctgca ctgcgcctga atcaacaatc ataaaaaaag gggctgcctt acagagaggc 3519061 agcccttttt aaatcaccga agacttttca cagaaaaaac tgccgatccc atcggcagcc 3519121 tgtttatttg atttttaaat tgtttgcaga tttcctcaaa aatgtttcta tcgactgaac 3519181 aaaaagtgca tattccttca tttgttcata tgcccgcgtg agaatttccg ccgtttcact 3519241 gtgcggcgtt gttccgccaa gcattttttt cagctgaagc agcacatcct tatattcttc 3519301 tcgcttatct tcaacttggt tagcagcctt ttccaaacat tccggtgtta tcttctgttc 3519361 atgtatattc aagaaaacaa ctccttttac agaaaaaaat agtaggttat cgttgaagaa 3519421 tagcacagat ggctcagatt tcacataaga aaatagaagg attttctaca taagtgtcca 3519481 aattccgaca ttcatttcag atttcccggt cgcactggct gttacttcat gatttcccgg 3519541 gaaaggaaaa tatcttgcac tcaagacctc ttctccgtta ttgataaaga tttccacaga 3519601 tgacgcgtcg agaaacatgt gtacggtatg caaatccttg atgcggcaat gtctcgcttc 3519661 tgttcttttt ccgtcaaagc tctttcgttc cagcgtaaca atcccctcgt ctttatggaa 3519721 ggaaaacgta gccgttccgc ggatactgat tgaaaagcca gactccgtat gaatgtcttc 3519781 cagtagaatc tcagttcttt caggtttttc cactggaagc gcaccagatg atccatgcat 3519841 gttgatgtgt atttttttct catttctgcg catggctttt agctcaggca gcggctgctg 3519901 aatcagcttc tgtcctgaaa gcgtcagctg tctcggcagc gtcatgcagt gaatccagtg 3519961 gcagtcaatg gtcggatggg acccttcatc ctgatcaggc accgccatcc atgcaaataa 3520021 aatccgcctt ccctgatcgt cttcaagtgt ttgcggcgcg taaaaatcaa aaccttgatc 3520081 aagctccgta aattcaccat gcttcagttc aggcttgtta taatcgaggc ggccgacaaa 3520141 ataacctgat tgatatacgt tctgataacg gaaaccgtca gcctcaagcc cttgaggcga 3520201 aacaatcagc acatccgatc cttgaaggga aaacaaatca gggcattccc acatgtatcc 3520261 aaaatcgtcc agcccgttga agcccgcgcc ggttatcggg ccaagaaatc tccactctgt 3520321 caggttatca gaagcaaaca acacagcctg ccctttcaaa ttctctgttt gcgcaccaat 3520381 caccatatac catgtgcctt catgctccca taccttcgga tcgcgaaaat gcgccgtata 3520441 tccttccgga aggcgggcga cgacaccctt tttctcaaag gacagcccgt cgtcagaaac 3520501 agcaaggcat tgatacgttt cccgatttcc atcctgatcc ctgacatttc ctgtgtaaaa 3520561 aagatagagc cgatcgtctt tcgtgacagc gctgcccgag tagcagccgt ttttatcaaa 3520621 ccaatcactc ggagccagcg caatctcttc ccgcttccaa ttcacaacat cctgtgtcgt 3520681 ataatgcccc caaaattttg cgccgtgccc cgtctgaaac ggctgccact gaaagaatac 3520741 atgatagctg cccttccaat aaatcacgcc attcgggtca ttcagcagcc caaccggcgg 3520801 catgatatga aaatgctggc ggtgcggatc gctgttagcg atgggctctt ttttctccac 3520861 ttcttcataa gcccggcgac gaagctcctg gtcatgtgct gtcatttttt cctctcctca 3520921 tcctcattaa tcttcatgac aaatgctgca atgaacgctg acactgccgc aatcgccatg 3520981 ccaatcagat agtgaatcaa gttgctgaag ccaaacggag ccgcaatggc gatcatcgga 3521041 attcccgtta acccgtaagc gtttgcagct acatgtgtaa agacgacata tgccccaccc 3521101 aatgcgcctc cgatcatcgc ggcgataaac ggttttcggt agcgcagatt gactccgaat 3521161 atgacgggct cagtaatgcc gagaaaagcg gaaaatgctg ccggaagcgc gatttctttt 3521221 gtctttgcct ttttcgccat aaagaagacg gcaagacctg ccccgccctg tgcgacattc 3521281 gccattgacc agatcggcag caagtagttt ttgcctatat ctgcaattag ccctgcctca 3521341 atcgcatgga agctgtgatg aacgcctgtc agcacgatga gtgaatacgt gcccccgaaa 3521401 atcagacctg cgacaaaacc ggcatggtca tatacataag ttaaagcaac cgtaatgccg 3521461 gagccaagcg ctctgcctag agggccaatc gcgataaaag caacaaaccc ggtgacaatc 3521521 acagtaacaa atggtgtaac aagcaaatcc accgcatgtg gaaccacttt tctcgtccat 3521581 ttctctacct tgctcatcac atacaccgca agcaggacag ggataacagt tccctggtag 3521641 ccgagaagag cgatatcaaa tccgaaaaga tgcatgtaat caggtgtcgc ttccgccaat 3521701 ccccatggat ttaaaagatt cggatgaatc atgattcccc cgatgaccgc tcccaagtat 3521761 ggattgctgc caaactcttt tgaagcgctg accccgatta gaatcggcaa gaaaatgaat 3521821 gctgcacttg aaaacatatc aagcagctgc aaaagcgcag aatccttgct catccaatga 3521881 aacgcattga tcatacccag caatcccatt aataggccgc tggctacaat agctgggatg 3521941 attggaacaa aaatattaga aagcgttttc gcaaatctcg cagcgggatt cagcttttct 3522001 tttgccgcat cctgatgatt gacgtgttct tcacgctcga tatcagcttc tttagaaaag 3522061 gcatcgaata ctttattcac aaggcctgtt ccgaaaatga tctggtactg gccagagctg 3522121 ctgaaagccc ctttaacgcc atcaagctct tctacttgtg cttgatctat ctttgattca 3522181 tctttcatca ctaaacgcag tcttgttgca caatgagccg cgctgataat attttctttc 3522241 cctccgagaa gctcaatgag gcgttttgca gtctctttgt aatccatcta tttctccccc 3522301 ttttatttaa acaaaaaaga cctaaaattc gccaacgaat aaaggacaca gcgatccttt 3522361 ttcatttacg caaattttag gtcttgcctg ctttaccagt cacaatcccg cttattcaga 3522421 ttaagaatac gctttcatca taaatcatga tagcgttttc gtcaactatt tttttagtta 3522481 aatagtttga tataacatgt agacaaaaat tcgtaaaaat taattgtgaa atacttcaca 3522541 atatcgtgct atactatgct caatcatgaa agaaagcagg aaaagacaat ggaaactcaa 3522601 gcattacaaa aggttgaaca gtatgctttg aaaaaacaaa acatattcgc ttcaagcaaa 3522661 atccgttatg tgcttcggtc cattttggcc agtatattta ttggttttgg cattacagcc 3522721 gcaagcaaaa caggcagcta tttctttatg gctgattctc cgtttgcctt tccggcagcc 3522781 gctgtcactt tcggggccgc tattctgatg attgcttacg gaggcggaga tttatttacc 3522841 ggcaacacct tttatttcac ctataccgcg ctccggaaaa aaatcagctg gcgcgacacc 3522901 ctatacttgt ggatgtcaag ctatgccggc aatttaatcg gcgccattct gtttgccatc 3522961 ctgatcagcg cgacgggact ttttgaggag ccttctgttc attccttttt gattcatttg 3523021 gcagagcaca aaatggagcc gccggcttcc gaattgtttt tcagaggaat gctgtgcaat 3523081 tggcttgtgt gcctcgcctt tttcattcca atgtctctca aaggggaagg agcaaagctt 3523141 tttaccatga tgcttttcgt tttctgcttc tttatttccg gctttgaaca cagcattgcc 3523201 aatatgtgca cattcgccat ctcgcttttg atcgagcacc ctgatacagt gacactgatg 3523261 ggagcagtca gaaacttaat ccccgttacg ctcggcaatc tgaccgcggg aatagttatg 3523321 atgggctgga tgtactacac actgaatcct gatcaataaa aaaacttcca gagatcactc 3523381 cctgcaagtc aaagcggtta ttccgagaga tcttgaagac gctggacatg cagcgtgata 3523441 tagccggcct cggattccgg caaatgtaat tgatattcat ttttcaaaaa ctccgccagc 3523501 tccagcgcac attgataggc gaatgaatac tttttttgga tgaaataaag catctcctcg 3523561 tccatacgat ggagcgcttc atttgattcc aaccggctga ccgcgtatcg caaatgcgtg 3523621 acaaggcgtt gataggaaat gctgttttca tccacctttc gattaaagta ttgttttatt 3523681 ttctctatca tttctttgat catggtcgta tgcttcagcg ctgaatacat gctctccgca 3523741 tccatcttcg ccgtatggat gtgaagggca atataacccg cttcatcttc aggcagagac 3523801 acgcccaatg tctcttttac atgtccgatc gcccacaggc cgatctcata ttctttttta 3523861 tagagcgcct ttatctcatg cagcaattta ttctgcacaa gcagcccatt ttgaatcctt 3523921 tcgatcgcaa aggacaaatg gtcggaaagc gcgatatgaa tgtgatcgct cagcggcgcc 3523981 gcgagctctc cttccgcata gctgatgata tcctcagcta tttctatatg ctcctccggc 3524041 agtgtttgca ggatttgttt gaacttttca ttctcgtcgc gcacgacaaa gatcttttcc 3524101 actttattca tagggatgag atcatttttc tttttttgaa aagcgattcc cggtcccatc 3524161 acgatttttt cctgatcatc ctcttttatt aaagccgcat tgttgtttaa tactttatag 3524221 attttcaaga ggttatctct cccgccaatt tgcttttgac tgggatttta cctccttttg 3524281 accgccatgt aaagatgcgg gcccgctctc tcctgctttg gcgattcctt gaaggcttgc 3524341 aaacatcttc ttttataaag cgcggcggct ttcgctttct gcttttcttc ctcattcaca 3524401 gccatccgcc attcataaaa cgaaacgagt cctgcggcct gcacagccgc ctttctttgg 3524461 tatgtacgct gagccgaata gaccgcggca gccgcagttt ttctgtccgg cgtcacccag 3524521 ttcatcaaaa agaccatcca cacccgtaaa gatacaagca aacgtttcat agaaaaacat 3524581 ccctccgctt ctttttggca ggcagccttt ttagcagccc gttttctcag ccgcagcccg 3524641 caagaaaaga cggccgattt cttttctcgc aaactagcgg ctctagcaaa actcatgact 3524701 ctatgataga ccgtggaaag agaattcttt gtcacaatat gagtgaaaaa accaactagt 3524761 ttttagaagt tttgttgaaa gctgaaagaa ttgaaatgaa aattggagaa ccgctttgaa 3524821 aactttatac acaagttatc ccaaagataa gaacaactta atcacaagag atatccacat 3524881 gtccacaaac tctatctata ttttgtatac gaacgtatat tcctaactat atatatacac 3524941 aggtttattc acttatacac agggttctgt gtataactcc ttcgttatac acaaacaaaa 3525001 tccaataaat ggtccaaatg acacaaggat ttttttgaat tttcaagaaa tatatactag 3525061 atctttcaca ttttttctaa atacaaaggg ggaaacacat tgaaaaaggg gatcattcgc 3525121 tttctgcttg taagtttcgt cttatttttt gcgttatcca caggcattac gggcgttcag 3525181 gcagctccgg cttcttcaaa aacgtcggct gatctggaaa aagccgaggt attcggtgat 3525241 atcgatatga cgacaagcaa aaaaacaacc gttatagtgg aattaaaaga aaaatccttg 3525301 gcagaagcga aggaagcggg agaaagccaa tcgaaaagca agctgaaaac cgctcgcacc 3525361 aaagcaaaaa acaaagcaat caaagcagtg aaaaacggaa aagtaaaccg ggaatatgag 3525421 caggtattct caggcttctc tatgaagctt ccagctaatg agattccaaa acttctagcg 3525481 gtaaaagacg ttaaggcagt gtacccgaac gtcacatata aaacagacaa tatgaaggat 3525541 aaagacgtca caatctccga agacgccgta tctccgcaaa tggatgacag tgcgccttat 3525601 atcggagcaa acgatgcatg ggatttaggc tacacaggaa aaggcatcaa ggtggcgatt 3525661 attgacactg gggttgaata caatcaccca gatctgaaga aaaactttgg acaatataaa 3525721 ggatacgatt ttgtggacaa tgattacgat ccaaaagaaa caccaaccgg cgatccgagg 3525781 ggcgaggcaa ctgaccatgg cacacacgta gccggaactg tggctgcaaa cggaacgatt 3525841 aaaggcgtag cgcctgatgc cacacttctt gcttatcgtg tgttagggcc tggcggaagc 3525901 ggcacaacgg aaaacgtcat cgcgggcgtg gaacgtgcag tgcaggacgg ggcagatgtg 3525961 atgaacctgt ctctcggaaa ctctttaaac aacccggact gggcgacaag cacagcgctt 3526021 gactgggcca tgtcagaagg cgttgtcgct gttacctcaa acggcaacag cggaccgaac 3526081 ggctggacag tcggatcgcc gggcacatca agagaagcga tttctgtcgg tgcgactcag 3526141 ctgccgctca atgaatacgc cgtcactttc ggctcctact cttcagcaaa agtgatgggc 3526201 tacaacaaag aggacgacgt caaagcgctc aataacaaag aagttgagct tgtcgaagcg 3526261 ggaatcggcg aagcaaagga ttttgaaggg aaagacctga caggcaaagt cgccgttgtc 3526321 aaacgaggca gcattgcatt tgtggataaa gcggataacg ctaaaaaagc cggtgcaatc 3526381 ggcatggttg tgtataacaa cctctctgga gaaattgaag ccaatgtgcc aggcatgtct 3526441 gtcccaacga ttaagctttc attagaagac ggcgaaaaac tcgtcagcgc cctgaaagct 3526501 ggtgagacaa aaacaacatt caagttgacg gtctcaaaag cgctcggtga acaagtcgct 3526561 gatttctcat cacgcggccc tgttatggat acgtggatga ttaagcctga tatttccgcg 3526621 ccaggggtca atatcgtgag cacgatccca acacacgatc ctgaccatcc atacggctac 3526681 ggatcaaaac aaggaacaag catggcatcg cctcatattg ccggagcggt tgccgttatt 3526741 aaacaagcca aaccaaagtg gagcgttgaa cagattaaag ccgccatcat gaataccgct 3526801 gtcactttaa aggatagcga tggggaagta tatccgcata acgctcaagg cgcaggcagc 3526861 gcaagaatta tgaacgcaat caaagccgat tcgctcgtct cacctggaag ctattcatac 3526921 ggcacgttct tgaaggaaaa cggaaacgaa acaaaaaatg aaacgtttac gattgaaaat 3526981 caatcttcca ttagaaagtc atacacactt gaatactcat ttaatggcag cggcatttcc 3527041 acatccggca caagccgtgt tgtgattccg gcacatcaaa ccgggaaagc cactgcaaaa 3527101 gtaaaggtca atacgaagaa aacaaaagct ggcacctatg aaggaacggt tatcgtcaga 3527161 gaaggcggaa aaacggtcgc taaggtacct acattgctga ttgtgaaaga gcccgattat 3527221 ccgagagtca catctgtctc tgtcagcgaa gggtctgtac aaggtaccta tcaaattgaa 3527281 acctaccttc ctgcgggagc ggaagagctg gcgttcctcg tctatgacag caaccttgat 3527341 ttcgcaggcc aagccggcat ttataaaaac caagataaag gttaccagta ctttgactgg 3527401 gacggcacga ttaatggcgg aaccaaactt ccggccggag agtattactt gctcgcatat 3527461 gccgcgaaca aaggcaagtc aagccaggtt ttgaccgaag aacctttcac tgttgaataa 3527521 gaaaaagccc tgccgattcg gcagggcttt ttaaagatca gtcagcaaac gcctcctgca 3527581 ataagcgata cgatcggagc ttatcttcaa aatgatgcgt gatggtcacc accatgattt 3527641 cctctgtttc atacgcgtta ctcaaagcta acagccgctc cttaacctgt tctttcgtac 3527701 caacaatcat tcgatttcga ttatcagcaa ttcgtctctg ttcataagga gaatacgtat 3527761 ttttccgaac agcttcatac gaaggaactc cctctaaagg aataccctgc tctcccgcca 3527821 aaagtgtaaa atcaagcaca gccccaagct cctctgcctt ctcctccgtg tcagcacaaa 3527881 gaacaaaaac agcaactgcc gctcgaggcg tatctcctaa cacagacggt ttgaatcgcc 3527941 tcttatactg tctgacagta ccctctccgc cctctccatt gataaaatgg gcaaacatat 3528001 agccagcgcc agattcagct gcgagcagcg cgctttctcc agatgagccg agcagccaca 3528061 catccggagc cgttgaaata tgcggcgcag cggtcagatt cggaaaacgg tgtttgtcat 3528121 ccgccaaatc atgcaaatac atggtcagct ccttaatttg ctgcggatac tgatcagcat 3528181 tgcgcttacc accgtcattc agcgcccatg atgcaatcgg cattcccccc ggtgctctgc 3528241 caagccccag gtcaattctt cctggtgtca gcccctccag aacacgaaag ttttcagcta 3528301 ctttataagc actgtaatgc ggcagcatga ctcctcctga tccaacacga attcgctttg 3528361 ttttcgctgc tatatgactg attagcacct caggactgga ccctgccagc cgttttgaaa 3528421 agtgatgctc agaaacccaa aatctcttat atccaaggtc ctcagcagct tgggcaagcg 3528481 caacggtttg ctgtaaggcc gtttctgcat tgctgccctc tgatactgga gattgatcta 3528541 atatacttaa tgaaaccatc cctaccacct catcctcatc gtatcactga tcccctattt 3528601 tttctccaaa gccgctcaca ctgcttatca gtgtccccta tcattcgcca tttatttgtg 3528661 aaagcatgtc cctatttgtc ggaatatgtt acacgtgaaa cataaaaacc cctccagacg 3528721 gagaggtttg ctttagtttt tattaaagcc cttttctttc acgtagtcat ttaaatacgt 3528781 acgcggcttt tgcttcataa agttcagtat ttgatcggac cacgtttctt cccgcttccc 3528841 gtttgttctt tctctatagt aatcagaaat ggttttgtca tacgtattca tagtatgacg 3528901 gaaatcgtct gtgttcacat tatacgtatt ttcatgataa acggcctgct ttggcaatct 3528961 cggttttttg ccggaaaggt tcgcaggatg gcctactgcc agtccgaaaa gcgggagcac 3529021 atggtcaggc gtttgcagca cctctgtcac cttgtccaat tcattccgaa tgccgccgat 3529081 atagcaaatg ccaagcccca tggattcagc ggcaatgctc atattttgcg ctgccagcgc 3529141 cgcatcaatc aagctaacca taaacatttc tgtattctcg agcagctcag aaatatgttc 3529201 acctttttcc tcagccagtt gttgatggcg gtacaaatcc gcacaaaata caaaaaagtg 3529261 tccgttcttc tcaacgtaag gctgattccc agcaagcacg gacagctcac gttttttctc 3529321 aggatcagaa accccgataa tcgaatatgc ctgcacatag ctggatgtag acgcagcctg 3529381 cgcacttttc actaatgtat caatttcttc agctgtcaaa agctgatcag taaaagaccg 3529441 gattgaccga tgattcaaaa tggtttcgat tgtgttattc atcacaaaaa cctccttatc 3529501 actttttatc atatccgaaa aaaagtgatc tcaaaagtga aatgctctgc acaaaaaaag 3529561 acagcctctg taaaggctgt ctgcatatca agaattaaaa agataacttc tgtatttcgt 3529621 cagctgcaca cttgcattat atacaatccc aaatccgatt aacgtggaaa gtgtcgagct 3529681 tcccccatag ctgacaaaca gcagcggaat cccggtaaca ggcataatgc caatgttcat 3529741 tccgatattc tggaatgtgt ggatcacaat taacgccgta tagccaacgc aaaagaaaga 3529801 agcgaaacgg ttaaacggat gtattttgtc tatcagaaca acaagcctgt agattaaaaa 3529861 gaagaacatg atgacaacaa ttgcacagcc tataaagcca aatgactcac ctattataga 3529921 aaagataaag tcagtcgtac tctctggaac ataaaccttc aaattagaaa taccattacc 3529981 taaaatacca ccagatccta ttgccatgat ggcctggtca acttgccagc tgtcatttga 3530041 atcttcctgt gtctcatttg aagcagacac ccaagaagtg acccgcttaa tttgataatc 3530101 ctgtattcca actgatttag caacgtcagg aaagtttatc attactaata aaattaatga 3530161 aatgagtaag atacctgaac cagctatgat cgcaatcaat ttccaattta tccctgacat 3530221 aaaaaccatt acaagaacga taaacataca tattcccgca gtcccagcat cctgcatcag 3530281 gataagacct acaggaataa ctgcgacacc cgcaatcttt aataacaagt ggatatcatc 3530341 cctaagcgtc cgaactcctt taggatttgc ttttccaata actgaagcaa gcatcataat 3530401 caaaccaacc ttcataaact ctgacggctg tattgttatt ctaccgatcc taaaccaact 3530461 ttttgcccct ttaataacag gtgcaataga ctcgggactg attttaagaa taatcaaaga 3530521 taaaatacca atgataaaaa tatataaact taacttttca agctgttcta aatcaaagta 3530581 caaaagaact gtaatggcta cagcccccaa aagataaaac acaatttgct gaatccaatc 3530641 cgtgttccca tactgcccaa actgaccggc agcatatatt gatactacgc ttataataaa 3530701 aaacacacca aatataaaaa tcaaatcccc ctggtaaaag gggctttgct gtttcttata 3530761 tcgactcatt ctatcccgcc ttacattttc atcggaaaat cactaatgtt tattatacat 3530821 gaaccacgtt caagatgaca cgtgaagctc gcttcctttt atgttttttc agcatttgcg 3530881 gcgctttttc agctacacga aatatgacgt atcataaacc gaaatgtttc gattgacaca 3530941 aaacttttca aatgaaaaaa acgccatacc aatagaattt gttaaaaaac gaatgcgata 3531001 atgtgttatg ttcccaaata atgtgatacc tcatatagaa atagctaaaa attcagagcc 3531061 ccatgcccat acattctcct agcacattaa acgaaaaaat aagacgatag atccagtcca 3531121 tttctgcaaa aacacgtatc aatttctgga aaacatggta taataattgt aacagaatgt 3531181 tcaaaaaaca atcacaaaac agacacaact cagttcctct atttcatttt tgtaaacgtt 3531241 atcacaaaat gaaaggagac gggtatgatg gacatgtttt ttgcttactt attggttgcc 3531301 agcgcaacgc ctctctttat ttggcttgat aacaaaaaag tcgcactctc agctattccg 3531361 ccaatcattt taatgtgggt attcttcttc ttttacgcaa cagaaagcct ttctccactt 3531421 ggacacactc tcatgattat cttgtttgcc gttaacgtca ttgtcgctca tatcgccgca 3531481 tttatcattt acggccttcc gtatcttcgc agaaagcgaa gcagctgaag acagcaaaaa 3531541 accctcttcc actgaagagg gttttttgta ttattcgtta tggcctgaat gctctgagtg 3531601 ttcagcgcct ccaggaggat ttccgtccat atggtcacca tggtgatagt gagccgcgaa 3531661 aatccagatg gatccaagta cgataacgat cgcgccaaag aatccgaaca gcgtgtttcc 3531721 gacttggatc gtgccgtttt cgctctctgt catatgcatg aacatgagaa gctgcagcgc 3531781 cgcctgaatg aaggcgaagc cgaagataat ccaaagtttt gctgatgagc tcaggtcagt 3531841 atacactgca acccatagag ccagcagggt caaaacgata gacaggataa aacctacaat 3531901 gtgtttccat ggaaagtgac tgtgttcagc agatttgttt gccattttac agacccccca 3531961 atcccatgag atagacacct gtaaagatga aaatccatac aacatctaag aagtgccagt 3532021 acaagcttga gataaagatt ttagatgaag tttgcggagt taagccgcgt ttcttcaact 3532081 gaatcagaat tcctgtgatc cagaaaatcc cgattgttac gtgagttccg tgagttccaa 3532141 gtaaaacaaa gaatccagac cagaacgcac ttgtactgag agccgctcct tcatgtacat 3532201 agtgaacaaa ctcgttgatc tcgcatccga cgaagccggc accgagaaga agagtgataa 3532261 ttgtccaaat gactacgcct tttaaacttc cgcggcgcat ttcatgaaca gcgatcccgc 3532321 aggtaaagct gctgatcagc agcaagaacg tcataatcat taccagattg acttcaaata 3532381 gttcgtctgg caagacacct ccagctgttc tgtttttaag aacgaagaag gttgcaaata 3532441 gtgttgagaa caacacaatt tctgccccta aaaagatcca aaacccgaga atattaagtc 3532501 tgccggtttc agattgatat tccataggcg cgttagaatt gccgtgttct gcatgttcca 3532561 taactcacgc ctccttattc ggaaatcttt ctttccgtct cttttatttc atcaacacta 3532621 atgtagtagc cgttgtcgta ttcgaatgaa cgcagaacca tgcagagcag gactccgatc 3532681 aatccgacta cgcccatcca gtaccattca aagacaagtc caaagcctgc gagaccgaag 3532741 gcaacagaca taaagaacgg tctgcctgag ttgcttggca tatggatttt cttgaatttg 3532801 ctttcagggt ataattcagt tttttcttct ttcatatgca ggaatgcatc ttgagatttg 3532861 acttcaggaa gcaccgcaaa gttgtaatgc ggcggaatcg cagaagaagt cgcccaatca 3532921 agcgtacgtc ccacacccca tgaatctccg ctgatttcac gagtagagta acggaagctg 3532981 tagtagatgt tatagcaaag gattaagaat cctacaccca tcatgaaagc tccgactgtt 3533041 gagataaagt tcaatgttgt ccagccgtca ttcggtccgt atgtgtaaat acggcgcggc 3533101 atgccttgaa gccccaagaa atattgcggg aagaaacaaa tattgaaccc gatcataaag 3533161 atccagaaga accattttcc gattctttcg ttcagcttgt ggccgaacat ttttggatac 3533221 cagaaaataa atccggcgaa acaagcaaat acagtacccg caatcagcac atagtggaag 3533281 tgagatacaa ggaagtacgt attatggtat tgataatccg ctgctgccat cgcaagcata 3533341 acccctgtaa ccccgccgat aacgaagtta ggaatgaacg caagcgccca cagcataggt 3533401 gttgtaaagc tgattcggcc tttatacatt gtaaagagcc agttaaagat tttaaccccg 3533461 gttgggattg agattgccat tgtcgtaatt gagaagaatg agttaacgga cgcactgttc 3533521 cccattgtga agaagtggtg agtccaaact aagaaactca atacagagat ggcgataata 3533581 gaaccaacca tcgctttgta accaaacaat tgttttcttg caaagcttga gatgatttct 3533641 gagaaaatac caaacgccgg aagaataacg atatatactt caggatgtcc ccaaatccag 3533701 aacaagttag cccaaagcat cggcataccg cctgcttcca atgtgaaaaa gtgagcgccg 3533761 aacaaacgat caaatgataa aagtgctaat gctactgtaa gtacagggaa cgcaaacacg 3533821 ataataacca ttgtgatcag tgttgtccat gtgaacatcg gcatacgcat taatgtcatg 3533881 ccttttgttc tcatttttaa gattgttacc ataaagttga tccctgtcat cagggtaccg 3533941 ataccggcaa tctgaagtcc gaggaggtag tagttctcac ccggcccagg gctcatgtcg 3534001 ttacttgcaa gcggcatata actcgtccag cctgcgttcg gagaacctcc gataacgaaa 3534061 gaaatattga aaagcatcgc ccctacaaag aacgtccaga agctcaggtt gttcaagtaa 3534121 gggaacgcaa cgtcgcgggc accgatttga agaggcacaa caacgttgat aagaccgatt 3534181 aagaacggca tcgccatgaa gatgatcatg attgtaccgt gagttgtaaa aatttcatta 3534241 tagtggtttg agtctaaaaa actgttattc ggaagcgcta gctgggcacg catcatcaga 3534301 ccgtcgacac cgccacggaa taacataatt acagcagata taatatacat gattccgagt 3534361 tttttatggt caacagtagt tatccattca gaccacagcc atttccactt tttgaagtaa 3534421 gtcagaacaa aaataatggc aatggttgaa agcgcaatgg aaacttgtgc gcccagaatt 3534481 aatgggtcac cagttacgaa aaattcgtcc catttgaatt tcatgcaggc ttcctccttt 3534541 cctgatcaat atcattcttc tgtatcatca gacttcttaa attcgttttt ctttacgttt 3534601 tcaaacggat ctgttttaga atgcggtgaa acggcttgat agccaaggcg tttgcgcgcc 3534661 tccatcgcgt actcagcgtc ttgtccgtga tcaacgtatt tcaagtgagt agaagagaac 3534721 gttaattcgt ccacattttc aggaagcatc aattcatcat acttctcttt tgtcagctta 3534781 ggagcctcgt tctgagtctt tttcacccag ctgttaaagt ctttttctgt gactgcattc 3534841 acatcaaact cttggtctgc aaaatgttca cctgtgaagt tcgcgttgcg gccttcgtaa 3534901 gtacccactt tgtcagcctg taagtattga tccatcagca ttcctgccat cgcatatttt 3534961 tgccctccaa gctgaggaat ccatagcgaa gccattgaat ctgcagatga gattttgaac 3535021 aagatcgggc ggtcgacagg aatgtttaag tagttgaccg tttcaatatc ctgttcaggg 3535081 tagctaaata cccatttcca gtctaccgaa gtagcataaa caacaagagg ctctttgtct 3535141 tttgttgctt caggagcttt ttctaacgaa tatatcgtct gtactgttgg cacagaaagt 3535201 gcaatgacga ttaaaattgg gatcactgtc cagactactt ctaaaaacgt gttaccgtga 3535261 atttctgggt tataagatcc attatctttg cctttacggt cgcggtattt tactaaaata 3535321 atggtaaata gaacaaagac gaccccgacg ataaacagca taaatccgat agataacagg 3535381 attaaatcac tttgctgttc agctacaggt cctttcggat ctagtactga agcattgctg 3535441 catcccccaa ggacgaaaac cacagttaac agcgctaata caagcaacgg ttttaatgct 3535501 ctgaacaaga agatcaccat ccttcctatt gatgtaataa atctgaagtg catacttcct 3535561 caaaatcttt tctctacttt gttatgctat caaaaacttc acttattagc tttatttttt 3535621 tataaacttc atcccatttt cgcttaaatg tcataaaatc gacaaaaatt gctccaactt 3535681 tattcacatc tatcgcttaa gatgaaaagt ttctagttat ttccgcatat aaagtaaaga 3535741 aagatgatga agaactaatt ctgacaaatt aaggtttacc acaataaaaa acttaggtca 3535801 atcaaaaatt tcattttgtt aaactttcta gataggaatt attttttcct cgtctagcat 3535861 cttttcacac ggttaccatt ttaacgcatc aaatattgaa agaaaaggcg caatgaagag 3535921 ccaatatgct ctgaattgtc cgtatttttt tatgagagca tccagttgtt tatcttatac 3535981 aaaaaagagg aatgatataa gcaaataaat aaaaaatagg atgtgttgca tgatgagttt 3536041 tcttatttca cttatcgtcg ctattattat cggatggctt ggaagcctgt ttgtaaaagg 3536101 agatatgccc ggaggaatta tcgggtctat gatcgcaggt cttataggcg cctggatcgg 3536161 acacgggctg cttggaacat gggggccgca cctagccgga tttgccatta ttccagcggt 3536221 aatcggcgca gccattgttg tctttctagt aagcctgtta accagaaaaa gaggataaaa 3536281 gcagcagcac ccgaagcgtc agcgctttgg gtgtttgttt tgccataaaa atcgaaaaag 3536341 cctcaaccct agcggttgag gcttttgact ggtttggcgc ccaactgatc gatgaacctt 3536401 ctgaaggcct gttttccctc tgctgtctgc ttaaatacac cggcgtgttc aaggatgcgc 3536461 gcgaatacat gtcccagctc ttcttttatg actagatcta cgttctcttt tgttatggtt 3536521 cttttttcca tcgtccgaag agcccactca ctatgctttg cagtgagcgg attttgttct 3536581 aaggctgttt tcggatcagc agaacatagc gccgctgccg tttctttcat ttcctcctgt 3536641 aagcggccag gcaatatcgc caatcccatg acctcaatca ggccgatatt ttctttttta 3536701 atatggtgga cttcttgatg aggatgaaat attcctaatg gatgctcctc atccgtccgg 3536761 ttgttcctca gtacgatatc gagttcgtac aagtctcccc tgcgccgcgc aatcggtgtg 3536821 accgtattat ggggcgtatc gcctgtatag gcggcaatgc cggctttttc atcggaatac 3536881 gtctgccacg tgcggaagat atggtcagca gcttcggcga catgacccgg ttcgtctcct 3536941 tggagcctga gcacagacat cggccacttc actaagccca gcgacacgcc gggataatca 3537001 tttaattcat aaacgtcttc cgcttctgca cgtgccattg gaaaatcatg cgcgccgcct 3537061 tggaaatgat catggcttag gatgctgccg ccgacaatcg gcagatccgc gtttgaaccg 3537121 ataaaataat gcggatattg gccaagaaat gacagcagcc tttcaaatgt ttttttgctg 3537181 atctccatcg gttcatgttc accttttaag acaatgcagt gctccggata atagacatat 3537241 ggcgagaatt gcaggaacca ttgttcgtcc tcaaggatga ccggaatgat tctgtgattt 3537301 tgccgggctg gatgattcac gcttccctcg aagccgacat tttctttaca cagcaaacac 3537361 atcggataat ttgtctgttc ctgctctttt gcagccgcaa tcgctttcgg gtccttttca 3537421 ggctttgata ggttaatggt catttccagc tcgccatatt cggtcggcac cgtccaatga 3537481 acatttttgg cgattctgtc agtccgtata taatagacat cctctgaata ttgatagaat 3537541 tcctttgtcg cctgttttgg gccgtataat gcttttgtct cttcaaattt gcgaatgacc 3537601 tcggacgggg caggcacaaa acagcccatc agctttgcgc tgagcaggtc acggtacgta 3537661 tctgtatccg cttccattcg gccggtttcg gcagcccatt tatagatggg agctagcaag 3537721 tccggcaggc tttgtgactg cttgatgctg gtgctggagt tcggctcggg atgtgtgatg 3537781 cccagcgctt cataaagacg gtttctcgta tattcccgat cccagatcga aatcaatttt 3537841 cgttccaggc catactcaag cagctgttcc agatgttcaa taatactcat atgtcactcc 3537901 ccctttagtt ctctcgctcc ctctccgata tccgcgacat aaaagtccgc tcggagccct 3537961 gttttttctt gatatctgtc tccaaccttc tgaataaaat catcaacgaa ctcatctttt 3538021 acaatgctga tggtgcagcc gccaaagcct gctcccgtca ttcttgatcc aattacacct 3538081 tcgtgatccc atgccgcaaa cacaagctca tcaagttcag ggcatgttac ttcatagtca 3538141 tccttcaatg aaaggtggga ttccttcatt aactgcccga tttcatctat attgttctct 3538201 ttgaacatat gggccgtctt aatagcacga tgattttcgt atacagcgtg ctttgcccgg 3538261 cgtctgttcg tttcattttg gatcaggctg gaatgcgcat cgaaatcaga aggcttgatg 3538321 tcgcccagtg cggcaatatc gaggcctttt ttcagatcaa gcaatgcatc attgcattct 3538381 tggcgtctcg tattatagct ggagtcagcc aatgtccttt ttttgttcgt gttcgcgatg 3538441 accagcgcga ggcctgagac attgagtttg ctatattcat agtcaagcgt gtcacagttc 3538501 agcagcatcg catgatgttt tttccccatt ccaattgcaa attggtccat aattccgcaa 3538561 ttgacgccga taaaatggtt ttccgcatgc tgcgccattt tcacaagctc aagcgcatct 3538621 acttcaggat gaaaataact ttggagcacg acccccatca gcagttcaat agaagcggaa 3538681 gacgacagtc ccgccccgtt tggaatattc cctgaaaata caatgtcaaa gccatgggga 3538741 actgcatatc ccctctgttg aaattcataa atcacgcctt ttgggtagtt cgcccagtcg 3538801 tcttcttttt gatagcgaat gtcgtcaagg ctgcattcct tgatgcctgc gtttctaaag 3538861 ttatctgaat acatccggac aagcccgtcg tttctttctg caacagcagc atatgtaccc 3538921 attgtcagcg cgcacggaaa gacatgcccg ccgttatagt ctgtatgttc tccaatcaga 3538981 ttcactcttc caggtgcgaa aaaaaaccgt aacccctctt tttctccgaa tacacttgca 3539041 aatatcccct ttagctcttc ccgcatgtgc aatcaccttt ctggttttta ttttttattc 3539101 cccttatttc ttcatagaaa acggcagatc atatgctgca gtcctctcat accccttctt 3539161 cttttgtttt tttaaagacg agccatttgc tcgcaacata gttgacgaca acaatgaccg 3539221 cgttgtcgag tattttggcc aaggtttcat ttgtattgaa ctggccgaca agaatgatca 3539281 tcatgcctaa atctatgccg agagacagga cccgaacgct gaaaaaagca gtgagctctt 3539341 tcagcaggct ctgcagatca tgtgtttttt gctgaaacac atataattta tttgttatgt 3539401 aagcaaacag cacggacaaa atccaagcgg caacagtggc ggctttgtaa tccacattca 3539461 tgatctctac caatatataa aagctggcga tattcacaat ggttgtgaaa acccccataa 3539521 tgatatacat aattatttct ctatacttca ctgatgttcc tcgctttctg aaaaactttt 3539581 caaaattctt ggcctctcgt gctctctgtc taaagtaaaa aataccgaga gtgcgtctaa 3539641 aaagctgcgg aaggtggctg gctggcccaa tacatatgat tgtttgatga ttccgtcgag 3539701 gactgcacat attattttag ccgtatattc aggatcaata caggcgtcaa tcagctttct 3539761 ctccttcagc cacttaatat ataacacatt ttcttccacc cacaattcgt acagccggac 3539821 ataggccttg catttcttta agactttata tgtcggcatg ttcatggcaa acgaggtgat 3539881 gtcccacgac ggcttattta tgtaatagga ataaagcagt tctgcagcgt gttttgcagc 3539941 ctcgtccaat gtcagcgatt tcactgactc ccgctccatt tgatcaagat accctataat 3540001 gatctttttt ttcatctgac gtttttcgag aaggtacagc agaaaatcgt ccttgctgac 3540061 aaaatgaaca taaaatgctc ctttgctgta cccggcggct ctgctgatat cttctacaga 3540121 aaccggatca tacgctcggt caatcaacaa attcacgcca gcgtctataa aactttcaaa 3540181 tgttgcttct cttttaattt gaaatttgtt ttttttcata tttttctcct ggcggtaatg 3540241 attaccctta tcttacaccg gatcaatctt tagcggtatt tatttcttta aacggttatg 3540301 ctattcggtt tcccaggggt catttttaat aggctaaatg atttattttc atttacatac 3540361 tatccagtca gtatttaatt gtttattatt ataaataagg tccattggtt atattagtca 3540421 tttttttagg gaataggtag gtggtttttc cttcagtttg tgaacaccga gcaactatgt 3540481 gtgaaatttg ttgtactcgc ctccatcatc gcgctggctt gtcttttatt gcccgcatgt 3540541 tgcaggaaaa cattttatac aattggaggt tactatgaaa actcatgtta aaaaagattt 3540601 ggacaaaggt tggcatatgt taattcaaga agctagatcc attggattag gcattcatga 3540661 tgtgaggcag tttttagaat ctgagacagc atcaagaaag aaaaaccaca aaaaaaccgt 3540721 ccggcaagac tagtccgaac aggcggatct atttacctct ggcttttcta tcacctgatc 3540781 tgagttttca ccatatcctc tattcaaaag caaatcgctg cgctgagctt gaggacaaac 3540841 ggtgtgtcag ctaactacga cagacagccg gtgatgcgat cacctcttgg cacatgcatt 3540901 gtcataaaga ggtgatgcga acatgataac cgtgctctgg taaacagcag ctttgctgag 3540961 aacaagctgc attcggtgag gttttgaaag caaactcgtt tatacacggc cgagcttgaa 3541021 aaccttcgcc tgtctttaga ccactgtgtt cacctcttca cgacttcctt cttttttcat 3541081 cctccagcta ttgtacaacg cataaatcgg actttcagta catacctatt ggtgtacctt 3541141 tttgcttacg tttagcgaat aaaaggagga aagccatgta caaagctgat tataaacaga 3541201 ttgctgcaac gccgtctttt caagcttttt taaagcagaa acgcgctttt attgttcctt 3541261 ctgcgatttt cttttttgtt ttttattttt cactccctgt tttgacatct tatttcacct 3541321 ttttgaatgc accggccatt ggagctgttt catgggcttg gctgttcgcc atcgcccaat 3541381 tcgctatgac ctggatactg agtactgtgt attcccggag agccgcccat ttcgataagt 3541441 atgtaagcgc tttaaaagag gatctgaagg gtgaacagac atgaatatga ctgctttttt 3541501 attatttttg gcgattgttg gcctgacgct tattatcacg tattttgccg cgaagcggac 3541561 gaaaacgacg agtgagtttt atacggcggg cggcgggctc accggcgttc agaatggact 3541621 ggcaattgcc ggtgactaca tgtctgccgc ctcgtttctc gggattgccg gaatgattgc 3541681 gttatatgga tttgatggct tcttttacag catcggtttt ctggtggctt atctcgttgt 3541741 cttgtacatc gtggcggagc cgcttcggaa tcttggaaag tacacgatgg cagacatgat 3541801 tgccgctcgc tttaaagaaa agaaaatccg cggtgtcgcg gctctcaata ccattgccat 3541861 ctctactttt tatatgatcg cccagctcgt gggggcgggc gcgctgatca aactgcttct 3541921 agggctggat tataccgcgg ctgtcctcat cgtcggagtg ctgatgacca tttatgtcgt 3541981 gtttggcggc atgatcgcga caagctgggt tcaaattatt aaagctgttt tgctgatggc 3542041 cggcacactc gtgatttcga ttatcgtgtt ttcgaaattc ggctttagcc ttaataccat 3542101 gtttgaacag atgaaaacgg ctactccgct tggcgctgat tttttgaacc ccggaaataa 3542161 atacaaggtg ccgcttgaga ccttgtcgtt aaacttggca ctcgtgctgg gaaccgccgg 3542221 gcttccgcat atattgatcc ggttttatac cgttaaggat gccaagacgg cccgtacatc 3542281 cgttgtgtca gcgacatgga ttatcggtgt gttttacatt atgacggtat ttctcggctt 3542341 tggtgccgcg gcatttgtcg gttttgacgc gattacggcg gctgatcaag cgggaaatat 3542401 ggcggctccg cttttagcaa aagcgctcgg aggagacttt ctgttcgcgt ttgtatcagc 3542461 catcgccttt gccaccattt tggctgtcgt gacagggttg gtgctgtctg ccgcctcagc 3542521 atttgcccat gatatttaca gccagatcat cagaaaggga gaagcaactg aaaaagaaca 3542581 aatgaaagcg gccagatggg cttctgtcgc cgtgtcagtg ctctcgattc tccttgcgat 3542641 ttttgcacaa tccttaaatg tggcgttcct tgttgcactc gcgtttgcgg tagccgccag 3542701 cgcaaacctt ccgctgattg tgtttacagt cttctggaaa cgattcaatg cctcaggcgc 3542761 tttatggggc agcctgacag gcctgatcag cgcgcttgtg ctggtatcga tgagccctag 3542821 tgtgtgggac ccggccggag gtgctatttt taccggtgat ccgctcattc cgctatctaa 3542881 tccaggaatt atttccatcc cgctcggctt tctcggcgcg tggctcggaa cggtgctgtc 3542941 gtctgataaa acaattgatg aagatacgtt tgcagaaatt caggtgaagg cgcatactgg 3543001 cgtccatatg gaacaggaat aaaaaaagct ctctttatcg agagcttttt ccttactttt 3543061 tcttctgctc gtcagaaatc gctttttcaa atacatcctt gccggcagca cccggaatta 3543121 cagtgtcacc gataataaag gttggaacgg ctgtgatgtc agcctcttca taggcgtgct 3543181 tcaaggcttg gcgctgcacg tcctgatatg ttcttgtttc cagtgctgat ttgaatgatg 3543241 caccgtctaa tcccacttcc tcggcgagct tcgtcaagat gtcaatatcg ccgatatttt 3543301 ggtcctcctg gaaaaatgcc tgaaagacac gggtgttgta ttcatgtcct ttattgtatt 3543361 ccttcgcaaa atggaagcct tcaaacgcga ggtctgtata cggatggggc gagacgtttg 3543421 gaaaattgat ctcgactcct aatttctccg ccattggctg aattgatgtc tgccacatgt 3543481 actgtttaga aggatcattg accggatcaa gctgaggaga tgggcttggg cgcagttcaa 3543541 acggcatcca ctcgacttca acatcctttc cttttatcgc ttcttcaaaa gcggcttttc 3543601 caacaaaaca aaatgggcag acgtaatctg aataaacttt aatgtgtact gtcatgataa 3543661 tctcctttca tactaaattg attttaaact gtaacaatta aagttacaac tgttttttaa 3543721 taaagaagcc gatttaggct tctttcagat tgatgacaaa atcctaaaaa gttttaggat 3543781 tttgtcatcc tttcagcgtg attgaaaacc cttgaagtct aggaaagccg agcattggag 3543841 cggagcgaat gctctaattc gtgagcacca acgcacaggc ttgacaacga atgcgagggt 3543901 ttgtcgacac gctgaaagaa gcctgtaaag gcttctttta tgattccagc aaacgctggg 3543961 caatatattc tccttttttg cagccgcctg ggcatgcgta taaagcagaa ccgattgttt 3544021 gtgtatattc gtttaacgca tcctttgctg aaagagcctt cagcatcggg ataaactgat 3544081 tgtcgggatt tttttgaaaa ctgataaaca ggagacctgc atccatatag ccggttttcg 3544141 gatcaagtcc ttctgtgtaa gagaaagctc ttcgcaaaat ttgtttccca gtagatttcg 3544201 ctagactgac gtgtgaatta gacggaattt gattcagctt cacgggatct gtttcctttt 3544261 tctgcccaaa aggcgccccc gagctttttc tgcggccgaa ggtatcctct tggtccttga 3544321 gggaagagcg gtcccatacc tcaaggaaca ttttgatttt ccgaaaagcc atataggtgc 3544381 cgcccgtcat ccagtcaggc tcaccagact gaatccacac gatcgagttc atcaacgtgt 3544441 catccttcgt gctctggttg cctgttccat ctttaaaccc gaagaggttg cgcggtgttt 3544501 caccattttt tccaccgctt aaaaagcctt tgttcacaaa acggacctca caagtgccga 3544561 ccgcttgatt tagcaggtta cgcagcgcgt gaaacgccac ttgctcgtcg tctgcacaca 3544621 cttgaatgca gatgtccccg cctccctgct tttcatccag gttgtcattg ggcatcgctg 3544681 gaagagcggc taggtgcttc ggttttttgc ttttcagtcc gaagcggtcc tttccgtctt 3544741 tttcaaaaaa gccaggcccg aatccgaatg tgaccgttaa gttggaaggg gataaatcag 3544801 cagactcacc tgtatcctgc ggcggcagat actgatttct ctgctccgct gacattttct 3544861 tgccagacgt cagcatctgt gtgagacttg tccagtttct aaataacgta atgatgtcgc 3544921 ttttgtcttt tgctgttaca tccagtgcag caaaatagac atacgtctga tgggcagttg 3544981 tgattccggc ctgatgcttt ccgtaaaacg gaacaatctg ctcctcctct ttttcatcct 3545041 ttttcgatgg cttagccgca gtctgaacaa gcggagcgag accgccgaga ccgctggcac 3545101 cgatcgcaac ggctgccccc gccatcgctc cccattttaa aatgtcccgt ctgtgaattt 3545161 gttctggctt tttctgttca tcgctcatga tgttacaaaa ctccttttat agcacattcg 3545221 caatcttcga catggtttca gaaagagtcg tcagcttagt gctcagctct ctgatttgct 3545281 tttcacttaa tttatcataa gacgtatagg actgatcatt tgttttgtat tttgccatta 3545341 aaacttcaaa ttcgctgaac tccgtatcca gtttttccgt caagtcggag tgatctttta 3545401 caagcgcgct tttcactgtt tgataaacgg cttcggagcc ttccacattt gccataaggt 3545461 caactaaatc aattcgtgag tagcgctctt cttctcccgt gattttcgaa attccggctt 3545521 cgttcagaag ctccatcgcg cctgcaacaa tttgttcagg tgttaatttc agtgattgaa 3545581 ttgaaccgtc aagctctttt acatccttga gaagctggtc agctgttgcc ttttccccgg 3545641 aaatatcttg atccttccaa atggccttct caagcttatg gaagcctgtc catttgtctc 3545701 cttcttcaac atcgttttct cgtgcgtcaa ttttcggatc aagatctccg aggctttcag 3545761 cgatcggttc gattcgctcg taataaacac gcgctttcgc atataacgtt ttggactttt 3545821 cgatatcgcc ggatttcaca gcacccgtaa atgcttcagt cgctttgaca agctggtcac 3545881 tctgctcttt gacatagcct ttatactcat ccgctgcttt tgccagctga tcgctagcct 3545941 ttttgccgct cttcttcgct tctgtcaggt cttctaagga tgctttcaat gactcggatt 3546001 ctgtcttgat ttttcctgca tccggtttgt ctttttgcgc ttctgtgtag attggctgaa 3546061 gatgcttttc gatttctgta tattcgaatg gatagtcgct gcgaatatcg ttttcaaagg 3546121 aaagccagta gctgtttaac tctttcccct tcttttcaat ctctttttgg tctccttttt 3546181 ccactgagtc attcagctta gaaatgatgg tttccatttt atttacggat gcggtgattt 3546241 ctttagtgac cccgcttttt tcagatgaag ctttttcttt ggttgaagat gtgtcattgg 3546301 ctccgcagcc tgcgcacagc gcaaggatgc atccggctga tacagcgatt tttgtgaaat 3546361 tcattttgtc agttcctttc cgtttgtaaa atgttttgcc gcttctgaaa caagcgcaat 3546421 cagtaaaaag agtaaaatca acatttgcgg aatcgtgctg tacacagacg gataaattcc 3546481 tagcaccgat acagacggca gccagctttc tgcatcagac ggaagaatgc ccgccagttg 3546541 aaggctgtga acgccggttc cgagaaattt cacgcacata tacaggacaa ccgccattga 3546601 tagaagaaaa aacggcttca atggaatgcg cattccgagc ttgatcatca gaacaccgac 3546661 gatgacgaga acgataagcc ctgcggcagt tccgccgatc agttcagtga gcgggagctt 3546721 cccgacaagc ccgatgaaaa agatgaccgt ttcgagacct tctcttacaa ctgccagaaa 3546781 tgcaatgagc gcaaaggaaa gcaggcttcg tttttttagt gcctgtgact tctggatatt 3546841 gattttttct ctccatttat ccattgaggc gtttctgtgc agccacaccc cgacatacaa 3546901 aagcatgaca gcggacagta cgccggtaac gccgccaagc aagaaattgt tttctccgaa 3546961 tacactggag gagaacagaa ccgtgacacc gatgccggct gctaaggaaa cagccatgcc 3547021 ggcggacgcc ccgccccaga tccatgtcga ggaacgcgta acccgcgctt tttttgtcat 3547081 ggttaatagc gctccgatga caaggagggc ctccattcct tcacgaaccg ggatcagcgc 3547141 cgcatcccac cagctgtagc tgcttgaagc gatcggctcg agcaattgaa tcatttcgtc 3547201 aatttgcttt gatacctttt caggatggct gccgatctcc gccttcatca gcgccagatt 3547261 ttcctccgat gtcgtatagg cttctttcga ttgggacacg acatctccct caacagcgag 3547321 ccaggatgta actaaattgt cgattgcgga tgacgcttca tccaattgtt ttttttctat 3547381 gaactgtttt gtgtctttca agctttgtat ataggctgtt aaggacgccc ttgattgacc 3547441 tgaggatgtc tttttcagca cgacagcctg ctgataggtt tctaaatgag acgcaagctc 3547501 ttcaagctgt gttttgagct tacgtgcgtc ttgattgata aaagaaagag aaatcatcgc 3547561 gatattcgcg tccatttcac tgtgagaaga aaggttttct ttcttaatag aaggttcttc 3547621 ttttttccac ttcgccttga aggtgtcaaa cgtttgttgt gccgaatcca tatccccgtc 3547681 ttttacggat ttgatcattt gcttgtttaa ttgaattaat gcggcgatcg gatcatcttc 3547741 cgcatgtgcc gcagaaccga aaaccatcaa caagctgaat agaataagtg ccagcccccg 3547801 agccatcatg ttcctcctat aattgaaaat gattatcatt gtataacata atcatagcca 3547861 gttcctgtcc tttgtcaatt aaaatttgaa ggtctgaaaa ccttgatgga cagcaaaaaa 3547921 gctgtccttt tacagaacag ccctttgaag gaaaatgaac gattatcttc ctgttttata 3547981 cgtttgaatt tcctcacgaa acttgcgtgc agcactctca ggatcctccg cctgactgat 3548041 ggcgctgatc atactgacgc catcggcccc cgcttggata acaggtgcgg cattatctat 3548101 tgtgattccg ccgatgccga caattggaat gctgatgcct tggcggcgca ctgcttcgat 3548161 aagagataca ccctgtaccg ctctcgtatc ttttttcgtt tcagtcggat agatcggccc 3548221 aagcccgaca taatccgctc cgtcttcttc ggcttgcttc acctcagaca tcgtatgggc 3548281 agaaacgccg agaatcatat cacctatggc agctcttacc tctttcgcat ttgcgtcttc 3548341 ctggccgatg tggataccat cagctttcag attcagagcc aattccacat catcattgac 3548401 aatgaacgga acaccagctt cacggcaagc tgcctgcgct ttttcagcaa atttaatccg 3548461 agcctctcct gtcagcgcat ccccgccttt ttcacggaac tggtacaggg tggcaccgcc 3548521 ttttaacgct ttttgtacaa ctgtaacagg atcggctttc gtattgtttg accccataat 3548581 gaagtataca gataataact ctttcatcat ttcccgagaa atacgagtca tgagacagtc 3548641 accctttcta tagtcgccca ttcttggacg tcttgttcag taacagttga aagcttgttc 3548701 agcaattcaa tctgaaagct tccagggcct ttgtcagccg tctgctgtgc ggcaagctga 3548761 gcggcgaccc catacgaaga aatggccgca atagcagcaa acaatggatt ttcttccaca 3548821 gcgcaaaacg caccgacgac ggaagtcagc aggcaaccgg cgcctgtcac ttttgtcagc 3548881 agcttgtggc cgttatgaag ggtgtataca tgtgacgtgt cggctatgac atcaacttca 3548941 ccagttatcg caatgaccgt gtttagcttt tgtgccgcct gctgagccag ccggatgatg 3549001 tcgcctccac cttcacccgc atcaacacct ttgatcagcc aatcggtcac gccgacggta 3549061 tgggcaattt ccgccgcatt tcctctgatt gcagcaaggc gcacctcacg aatgatgtca 3549121 cgtgccgatt cagtgcggaa cggtgttgct ccggcaccga caggatcaag aatgacggga 3549181 acgccatgtt cattagctga ttttcccgcg atgatcatcg cttcgactga ctccttgctc 3549241 agtgttccga tatttaaaac gagtgcaccc gcaattttcg ccatatcggc gacctcttct 3549301 tttgcgtacg ccataacggg cgatgcgccg agcgcgagca ggccgtttgc tgtgaaattc 3549361 gttacgacat tgttggttat gctatgcacc agtgggctat gccggcggac agccgtaaga 3549421 cattttgctg ctgattgtgc atccatattt gcatcatcct ttactatctt ttttcgggtc 3549481 ccataaatac gatttcgtat gttcgagcca agctctggcg gcaaacgaca agtacctgtc 3549541 ctttctccaa ataatggcga ggtgccaagg gatgaccgga tcgacaagcg gaatgacttt 3549601 cactttttcc gggtcaaggc cgcggcagat ccgttccggc aaaagcccga tcccaaggtt 3549661 ggcggatacc atctcactaa taaaatccca ttgtgatgtt tcataaatga tatggggccg 3549721 gaacccagcc ttgatacatt ccgtcataat tcggttgtgc aggacaaaat cctctctgaa 3549781 gaaaataaaa ggctcgtcct tcaactcacg cagctgacat tctttctcat cagccagccg 3549841 gtgggaaggg tgaacgacaa gcattaaggt ttcttttacg attgtaaacg aatgaaagat 3549901 atcttcgttt gcgggaagga ccacaacgcc gatatcaaga gagccgtccc cgacaccttc 3549961 ttggactttt atagaaccgt cttcgactag ctgaaaggtg acattcggat agttttcacg 3550021 gaaatcgccg agcactctgg ggaaaaaccc cgatccgatc atcggcggca gtccaatccg 3550081 tacgtgccct ttcttgactt ccataatatc atttaattct gacgtcaggt tttgaaatga 3550141 tttaatgatt tcctgcgcct gcacatacat gctatgaccg gcatcagtca gttccacctg 3550201 cctgccgttt cggtaaaaca gttcaattcc gagctcttct tctaaatttt tgatcatttt 3550261 tgatatcgtc ggctgagaaa cataaaggga ttgggaagcc ttcgtaaaac tttttaaacg 3550321 ggcgacttcc aagaaatatg ttaaatggcg gatatccatg cgcttcaccc tttctataga 3550381 caaaaggaat acttcttatt cttaatatat attttaccta tagagagacc ttatgtacaa 3550441 taagtatata agggaggcat caatatgaaa aaactgttgc taaccgttat tcaaatcgct 3550501 ctgttattta tatttgctcg gctgattaat tgggtgacag cccttcttca tataaatatt 3550561 cccggcagta taatagggat tgtgattctt ttcacattat tgcactttaa cattatcaag 3550621 cttgaatgga tcgagcttgg tgcagcgtgg cttctcgggg agctgctttt attttttatc 3550681 ccgtctgccg tcggagtgat tgaatacgga gacattatgt cgaaatttgg tgtcagcatt 3550741 ctgcttgttg tcatcatcag cacgtttgtc gtgatggtgt ctacaggaac gcttacacaa 3550801 ctcatcgcaa agagaaagga gaaaaagcat acgtgttcat cggaattgta agtttgtttt 3550861 taacggtttt ggtgtattta ggagcaaaaa aggtatatca acgctttccg cgtgtttata 3550921 cgtcgccgct attggtgacg cccgctgtat tagtcggtct gctgctgctg gtgaatgtcc 3550981 cgtacgagtc ctataatctc ggcggcggat tgctgaccga tatgctacag ccggccaccg 3551041 tggcattcgc gatcccgtta tataaatatt tccctgtttt aaagaaatac gcagtggaaa 3551101 ttattttgaa tgtggccgtc ggttcatgca tcgcgattat ttctaccgct cttattgcga 3551161 aatggcttca cctcggcacc ggcttaattg acagcctcgt cccaagatca gtgacaacgc 3551221 cgatcgcgat gaacgtatct gaaatgatcg gcggtatgcc tgccgtcaca gccgtgtttg 3551281 tgattttaac cgctttgctc ggcacagtga tcggcccgat ggtcatccgt tatttccgca 3551341 ttgataacga aattgcgcgg ggcgtgctgc ttggcacaag cgcgcacgga gcgggaacgt 3551401 caaaggcatt tgagctcagc tctgtgtccg gcacgatttc cagcgtgtcg atgatcttag 3551461 ctgcgattat gacgctttgc gcggcgccgt ttttgctttc atttatgtaa aaaactgtcc 3551521 tctcgagggc agtttttttt atgtgcttcc ccttattgaa aagctggcga attccaatat 3551581 aatgtatttg tggataccaa aggaggcacc ctgatgcaca acttgcaggt gaggcggcat 3551641 tatgccgcgt taaaaggatt ttatttgttt gcttttctcg gtacgggcag cataattccc 3551701 ttactcagta tgtatttaac gaaggaacag catttaagcg gatcacaggt cggcttgatc 3551761 atgtcactgg gcccgattgt gatgattttc tttcagccgt tttggggcat gctgagcgac 3551821 tatacgcaaa aaacgaaagg cctgctggcg gtttgcacat caatcacagg catcattgga 3551881 ttagcctata ttgcatttga cagtttccct ctgtttattt tgattgcggc ctgttttgca 3551941 gcctttcaaa gcacgattat tccactttcg gacagcattt cactaaggta cacacaagaa 3552001 acaaacggca actacggcgg aatccgcctg tttggttctc tcggcttcgg tgtcgcggtg 3552061 tttgccatgg gacaggtgac gaaccagctg taccccattc acgtgatctt tatctttggc 3552121 tgtgcctttc tgtgcattgc tgccatattg gcttcacaag tgcccggcca gcagaaaaca 3552181 acaaaggtca atatccgcaa aggattccgg gagcttatca gcaacaaaac tttcctcatc 3552241 tttatgatca tcacctttac gacatttgct ccaaacttag cgaacaatac gtatttcagt 3552301 ctttttctgg acaaaagcgg cgcgtcactt tccgctatcg gcattttatt tttcatcggt 3552361 gtcatttcag aaattccatt tatgagattc gcccaaacat ttatagataa aatggggctg 3552421 ctcaacgtca ttatgctgtc aggcggagtc tcattattca ggtgggcgct ctatttcacg 3552481 gcgccttcac tatggatcat ttatgcgacg gtctttcttc agggagtggc catcggttta 3552541 tttatcccgg cggcgcttca atatgtgaaa aagattaccc caagacacgt tgaagcgacg 3552601 gcgctgacca tgtacgccgc cattggcaac gggttcggca actggttctg cacatttgca 3552661 ggcgggtaca tttttgacta cgtgtcgatc ttcgcagtct acttgctttt tggcattctg 3552721 agcatagcag gctttggcct gacattatat ttaatgaagg ctgaaaaaaa caaacataca 3552781 cttcatcagc cggctgttac ttttaaacca taatgactat aatgaacaaa agaaaggatg 3552841 tgcgttatga acgggcaaga gcgaaacagc atttcgaaag ggttgcaggt tgatattgta 3552901 ttgaaagcag atcaaaaaac aggaaaactg acgagaggga cagtgaagga tattttgacg 3552961 aaatcaaact ttcatccgca tggcattaaa gtccgtcttg aagatggccg catcggccgc 3553021 gaccagcaga tcgtttctac ataaaaaaaa gctgcccctg aacagggcag ctttttcatt 3553081 attttttctg cagaaggacc actttcaggt agttgccttc cggaaatgcc gaaatcgttt 3553141 tgaaatcctc cggcagcgta aattcctcaa tgatcgtgta gcgttcattt gtttctttaa 3553201 aggcggcatc aataaagcct ttgaacttct tcatgccaaa ggcgctgctg tttgtagagg 3553261 caacaatgac acccttgtca gcagtgatgg cgatcgtttc cttcagcagg tttttataat 3553321 ccttggccgc gctgaaggtg cgtttttttg tgcgcgcaaa ggaaggcgga tctagaataa 3553381 tcagatcaaa gcgcaaatcc ttttttgcag catatgaaaa atagttaaaa acgtccatca 3553441 ctttaatgtc gtgcgcttcg taatccagct tgttcacgct gaattgctcg atcgttttgg 3553501 caagacttcg atttgccacg tcgacgcttg ttgttttctc cgctccgcca agcgccgccg 3553561 ccacggagaa tgcacccgta taagaaaacg tatttaaaac ggttttccct tttgcatagc 3553621 ggtctctgat cgccttgcgc acatgtctct gatccaaaaa gatgcccgtc atggcgcctt 3553681 cattcagatc caccgcgtat tgaatgccat tctcttggat gatgatcggg aactcgcccc 3553741 ttctcccttt cacgaagtca tcatcttcaa cgtattgtcc agccgtgtcg aagcgtttct 3553801 tctcgtaaat cgctttataa tcaagatcca tctcatccaa tgcggaaatc agcatgtctt 3553861 taaaggtgta aattcccttg ctgtaccatt gaatcagcag gtagccgtca taatagtcga 3553921 tggtgacgcc gccgacaccg tcaccctcac cgttgaacag gcggaaagct gttgtatctt 3553981 gagcctcaaa tagtttggcg cgcgcttggg ccgcttttgt taatttgctg agaaaaaatg 3554041 cttggtcaat ctgttcatgt ttattgcggg taagcgtcca gccaacccct ttgttttgca 3554101 ggccgtaata gccccgcgcg agaaactcgc cgccgctctc agacacgata tcaacgaggt 3554161 ctccttcttt catgtgcccc gcactccctg cgagagcttc tttttcaata aggggatagc 3554221 ctttttttat tttggcagcg tgtgcttttt ttagggtgag tagcttcata tatgtcgtcc 3554281 tctttccgtt tgctttctct tatggtacca caaaacgcca agatgtctgc attgacagaa 3554341 aggaaaggtt tttctacgat agacaaaaag agttacgagg aggagcagca tggcaaaacg 3554401 aattgaccat acaggcatca tggtaagaga tattaacgcg tccatcacat tttatgaaga 3554461 ggtactaggc atgaaattga aggatcgcat cactcacacg aacggtgtaa tcgagcttgc 3554521 ttttcttggc tttgaagacg gcccggaaac agaaattgaa ctgattcaag gctacagcag 3554581 cgagcttccc gctgaaggaa aagtgcacca cattgccctg ctgacggatg acatcgcggc 3554641 tgaatataca aaagcggaaa aaatgaacgc aaaatttatc gacgaggaga tcacaacact 3554701 tccaaacgga taccgttatt tctatatcga aggccctgac ggtgagtgga ttgagttctt 3554761 tcagcggtaa aaataaagaa cgtacatttt gtgatgtacg ttctttttta tctataccaa 3554821 ctgatatacg ttgactcatc gcaaatcata gcttcccagc ccatacgctc aaccaattca 3554881 tggatgtttt tatctttggc taaaaagaca ttaatgaatg agtcatatac actcataaac 3554941 acaaaatcca ttttctcatc agttaaaacg agctctgttg cggcttcatc aagaaccgtc 3555001 cgcaagttgg cttcagttat gtccaaaacg ccgcggtttt ccacaatcgg ttctgcgtaa 3555061 taaaaccgat tggatccgtt cgcacctaat acctttacca aactcggaat atgaaaattt 3555121 gaaatatgat cctcactggg ataatagagg tctccattta tgttttcatg taacacctca 3555181 gccaaatcct ctctcgcgaa ctcgtccctt aaagcgccta tcgacgtcat taaagccagc 3555241 gccagctcag catgtgtttg aaagccgcaa gaagacataa ccttcttcca ggaaacagcc 3555301 ttgcctattc ctcttatttc attatcgttt ggataaatat gttcataatc attttttctt 3555361 tttgcattct cccatccttc aggcatttgg ataaaaggag aaaagataag agcagcagat 3555421 gagtattcaa ctggtacttg ttgtaagatt ggtgattcgt catctaacca tatataatct 3555481 agcatgcgca cctcctttac atattctaac attcctttcg tttgaaagag atgatcagcc 3555541 ctatgacagg ctgatcatct atcacatcac atttttatcc ccagattcaa ccgcactctc 3555601 ttcccgccat ttttgatgat cccatattct gaaaaacgga tagtagatag cacaggtgat 3555661 cagcagattt accagctgca taactgcgcc cgacaccttt ccgcctgtcg ccaggtaacc 3555721 tgatatgagc ggcggcatcg tccatggcac cgcgattccg gccggtcttg ccaccagccc 3555781 ggtgctcatg ccgatataag tcgcggtaat cgtgaggagc ggtgcgatga taaatgggac 3555841 aataaggagg ggattcatga caatcggcat gccgaaaatg atcggctcgt tgatattaaa 3555901 tagcgcaggg ccgattccta atcgtccaag ctgcttcatt tgtttgctgc gggagcgcac 3555961 aagcatcgtc aggacaagcg ccagcgtcgc cccgcttccg ccgacattga tccaaatttg 3556021 aaaaaactga gtcgtaaaaa tactcggcag cgcctcgcct gcttggaagg cgagacggtt 3556081 ggcatccatc gcgccgtacc aaatcggcgc catgattccg ccaatgatgg aagccccgtg 3556141 aatcccgcac gaccaaagca gcatctgcac aaattcagcg atcaggcttc cgccgagact 3556201 gccgccaagg atggaaagcg gtgtgccaag caggtctcct acgacattgt gcagactctg 3556261 aaaaggtgtc atttcaatca gaagacgcgc cagccatacg agaagcacaa tgataaagcc 3556321 gggaatcagc gcgacaaatg atttgcttac cgcaggcggc acaccgtctg gcattttgaa 3556381 gacgatattt ttttgaataa tgtaccgata gatttcggtt gaaaacaagg cgatcagcat 3556441 ggcgacaaat aagcccttgc tgccgagcag cgtgatcggg attccgcccc ctaccatgat 3556501 ggactccgtt gagccatgcg gtgtaaacgg cacctcaaac ggtgttgcca gcagaaatgc 3556561 ggcaattgaa atcgctccgg cagaaagggc atcgacacca tagctttctg ccagccgata 3556621 ggcgatccca aaagcggcaa tcatcgccat aatatcaaac gaagcgttaa caggatatcc 3556681 gagcttatcg gcccactcgt tcccaaacac actcgccatg aaatcagcat accccggaat 3556741 cggcaagctc gttaaaatca agaagacaga cccgataata atcagcggca tggtcaggat 3556801 aattccgtca cgcaaagcgc tgagatgccg ctgcccggca attttcccgg cgacaggcat 3556861 tattttttcc tccatcaccc gagtgaatgt gctcatctta aaaaccccct tttctcattg 3556921 ctttgtgaac aacctccgca atgttttctt tatcttattt tgaaaacgct tacaaattca 3556981 tttggaaaat ttcctcttca tgcggaaaaa atctgcattt tgctaaacaa ccctgcccat 3557041 gaaaaatttt ttccttctta ctattaatct ctcttttttt ctccgatata tatatcaaac 3557101 atcatagaaa aaggagatga atcatgaaaa acatgtcttg caaacttgtt gtatcagtca 3557161 ctctgttttt cagttttctc accataggcc ctctcgctca tgcgcaaaac agcagcgaga 3557221 aagaggttat tgtggtttat aaaaacaagg ccggaaagga aaccatcctg gacagtgatg 3557281 ctgatgttga acagcagtat aagcatcttc ccgcggtagc ggtcacagca gaccaggaga 3557341 cagtaaaaga attaaagcag gatcctgata ttttgtatgt agaaaacaac gtatcattta 3557401 ccgcagcaga cagcacggat ttcaaagtgc tgtcagacgg cactgacacc tctgacaact 3557461 ttgagcaatg gaaccttgag cccattcagg tgaaacaggc ttggaaggca ggactgacag 3557521 gaaaaaatat caaaattgcc gtcattgaca gcgggatctc cccccacgat gacctgtcga 3557581 ttgccggcgg gtattcagct gtcagttata cctcttctta caaagatgat aacggccacg 3557641 gaacacatgt cgcagggatt atcggagcca agcataacgg ctacggaatt gacggcatcg 3557701 caccggaagc acaaatatac gcggttaaag cgcttgatca gaacggctcg ggggatcttc 3557761 aaagtcttct ccaaggaatt gactggtcga tcgcaaacag gatggacatc gtcaatatga 3557821 gccttggcac gacgtcagac agcaaaatcc ttcatgacgc cgtgaacaaa gcatatgaac 3557881 aaggtgttct gcttgttgcc gcaagcggta acgacggaaa cggcaagcca gtgaattatc 3557941 cggcggcata cagcagtgtc gttgcggttt cagcaacaaa cgaaaagaat cagcttgcct 3558001 ccttttcaac aactggagat gaagttgaat tttcagcacc ggggacaaac atcacaagca 3558061 cttacttaaa ccagtattat gcaacgggaa gcggaacatc ccaagcgaca ccgcacgccg 3558121 ctgccatgtt tgccttgtta aaacagcgtg atcctgccga gacaaacgtc cagcttcgcg 3558181 aggaaatgcg gaaaaacatc gttgatcttg gtaccgcagg ccgcgatcag caatttggct 3558241 acggcttaat ccagtataaa gcacaggcaa cagattcagc gtacgcggca gcagagcaag 3558301 cggtgaaaaa agcggaacaa acaaaagcac aaatcgatat caacaaagcg cgagaactca 3558361 tcagccagct gccgaactcc gacgccaaaa ctgccctgca caaaagactg gataaagtac 3558421 agtcatacag aaatgtaaaa gatgcgaaag acaaagtcgc aaaggcagaa aaatataaaa 3558481 cacagcaaac cgttgacaca gcacaaactg ccatcaacaa gctgccaaac ggaacagaca 3558541 aaaagaacct tcaaaaacgc ttagaccaag taaaacgata catcgcgtca aagcaagcga 3558601 aagacaaagt tgcgaaagcg gaaaaaagca aaaagaaaac agatgtggac agcgcacaat 3558661 cagcaattgg caagctgcct gcaagttcag aaaaaacgtc cctgcagaaa cgccttaaca 3558721 aagtgaagag caccaatttg aagacggcac agcaatccgt atctgcggct gaaaagaaat 3558781 caactgatgc aaatgcggca aaagcacaat cagccgtcaa tcagcttcaa gcaggcaagg 3558841 acaaaacggc attgcaaaaa cggttagaca aagtgaagaa aaaggtggcg gcggctgaag 3558901 caaaaaaagt ggaaactgca aaggcaaaag tgaagaaagc ggaaaaagac aaaacaaaga 3558961 aatcaaagac atccgctcag tctgcagtga atcaattaaa agcatccaat gaaaaaacaa 3559021 agctgcaaaa acggctgaac gccgtcaaac cgaaaaagta accaaaaacc tttaagattt 3559081 gcattccaag tcttaaaggt ttttttcatt ctaagaacac cacacacaac ctttttccca 3559141 tccattgtac aggcttttca tactattgct atacagccat gaacagcata aaatgaacgt 3559201 tattacagtt atcaccacat atggcgggat tgtgactggg caggcaggca agacccaatg 3559261 atgcaaaggg agtattaatg cctaaaaaac agggcatttt aactcttctt ttcgtgttgg 3559321 gctcataacg gcgccttgga caacccccta ttctcatgct ccgtcgtcga cgcgggcatt 3559381 tttgtcattt tcagccggta tttctcactt ttttcatttt gattgtcaac ttttcatttg 3559441 atacgatgaa caagccgact tttcttcagc aaaggaggtt ttaattgctt gcataaagag 3559501 attgcaaaag aattactgct gctcgcagga ggaaaaaaca atattatcag catcagccat 3559561 tgtacgaccc gtcttcgttt tgatgtaaag gacgagacga aaattgatat acatgccatt 3559621 gagaacctgc aaggtgtgca gggcaccttt ttccgctatg ggcttttcca gattatcttc 3559681 ggagcaggcg tcgtcaacaa aatatataaa gaagtcgttc atgtatggga gaccgcgcct 3559741 tctgaagagc ctgtccacca gaaaaaagcc agccggaagc tgaaccctgc cgcagctttt 3559801 gcgaaaacac tgtccgatat ttttgtgccg attattccgg caataacagc aagcggcctg 3559861 ctcatggggc tgatcggcat gattaaggtg tttcattggt tcgctgccgg cagcccatgg 3559921 attaaaatgc tcgacctcgt gtccagcaca gcctttattt tactgccgat tttagtcggc 3559981 ttcagtgctg cacggcaatt tggcagcaac ccatacctag gggcagtgat tgcagggctt 3560041 ttgacgcatc ctgatctgct ggacccgtct atgctcggca gcaaaacccc gtcttcttta 3560101 gacatatggg ggcttcatat cccaatgatg ggctatcagg gttccatgat accgattctt 3560161 ctttccgttt ttgtcatgag caaaattgag aagctattaa aatcgattgt gccgaagtcg 3560221 cttgatgtcg tgatcattcc ctttattacg gtcatggtga cagggtgcct cgcgctgatt 3560281 gtgatgaatc ccgccgcgtc catcatcggc cagatcatga cacaatcgat cgtctatatt 3560341 tatgatcacg ccggcattgc tgccggagct cttttcggcg gcatctactc caccatcgtc 3560401 ctatctggat tgcatcatag cttttatgca attgaggcaa cgctgcttgc taatccgcat 3560461 gtcggtgtca actttttagt gccgatatgg tcgatggcga atgtggccca aggcggagcg 3560521 gggcttgcgg tattcctcaa aacgaaacaa tcaagcctga agaaaattgc gctccccgct 3560581 tctctgaccg cgtttttagg cattgttgag ccgattgtat tcggggtaaa tctcaaattg 3560641 atccgtccct ttatcggagc agccatcggc ggtgctattg gcggagcata cgtggttgcg 3560701 gtacaagttg tggcaaattc ctacggactg acaggcattc cgatgatttc aatcgtgctg 3560761 ccgtttggcg ccgctaattt tgttcattat atgatcggtt tcttgatcgc agccgtctct 3560821 gcttttatag ctacattgtt tctcgggttt aaagaagaga cagaataact ggatttattc 3560881 gatttcattc ataaaacggg ggatgaaagg acaaaaaagc tatgaaaatt aaaagaatct 3560941 taaatcataa tgctatcgtc gtaaaggatc aaaatgaaga gaagattctc ttgggtgcag 3561001 gaattgcgtt taacaaaaag aagaatgata ttgtcgatcc gtcaaaaata gaaaaaacct 3561061 ttatcagaaa agatacacct gactataagc agttcgaaga gattttagaa acattgcctg 3561121 aagaccacat tcagatttct gagcaaatta tctctcatgc cgaaaaagag ctgaacatca 3561181 aaatcaacga gcgcattcat gtcgcttttt cagaccatct ttcttttgca attgaacgcc 3561241 tgagcaatgg gatggttatc aaaaatccgc tgctgaatga aatcaaagtc ctttatccaa 3561301 aggagttcca gatcggctta tgggccagag cactgattaa agataaactg gggattcaca 3561361 ttcctgatga tgaaatcggc aatatcgcca tgcatatcca cacagcaaga aacaatgccg 3561421 gcgatatgac acaaacgctt gatattacaa caatgatccg tgatattatc gagattatcg 3561481 aaattcaact gtctattaat atcgttgaag ataccatctc ttatgaaagg ctcgtgaccc 3561541 atctccgctt tgccattcag catatcaaag caggcgaatc catttacgag ctggacgcag 3561601 aaatgattga catcattaaa gagaagttta aggatgcctt cctgtgtgcc ctaagcatcg 3561661 gcacctttgt gaagaaggaa tacggctttg agtttcctga aaaagaattg tgctacatcg 3561721 ccatgcatat tcagcggttc taccaacggt cagtcgcacg ctgagacaaa caaaaaacgc 3561781 ttttgatcat ctcaaaagcg tttttttatc tgatttattg gttgatcgcc ggattcccaa 3561841 tcgtattcca cttcgtatag gacatgtaat ggaaatactc atcgcgatac ggatgttttg 3561901 tattggagtt ccaaggcttt tctccgccgc agaagtgcac gattgccggg ttttctcttg 3561961 tttcattata ttgcttccgc cctaacagag tcgatggggt tttcagcttt aacatgatat 3562021 aggtttgagc gttccagcgc ggatgaagtt cataccactg atcatacaag atcgcattca 3562081 gtgcatcttg gtcatgcagc acaagaaagt cttcgtctgg gtgttcattg ataaagttga 3562141 tgactttttc tgtgatgttt tgctttctcc aagactcaaa atcaataatc atgatacctg 3562201 agttaaaata cttccctgta tcagtgacgt tcatttcttt caggcgttca tgctgccccg 3562261 catcctcaac agcggctacg gtgtatggcg caatgtctaa gtcccatagc ttagaaatat 3562321 cctctaggac aagcgcatca caatcgatgt aaatcattcg tttgatgctt tcatccttaa 3562381 ttaagtcggg aatcgaaatg cggtaatacg cggcttttgt aatatggctg ctctcaaccg 3562441 catgttcata catgttggta tccacttcta aaaactcaat cggcactccg aatttcaaag 3562501 tggtttcttc cagtcttttt ttgttatcag gcttaattcc gccatcaatg acgtataatt 3562561 ttacctctct ctcctgatcc atgttagtca ataaagaaac gaacatccca cctaaatgac 3562621 gagcataatt atcatctgcg catgatacga tatgcatgat ttcatctttc ctcaatggta 3562681 ttcatctccc tttttgttgt acaagttaca tacccttttt caaaaaaata aacacgttct 3562741 ccgacatttt tttaaacaga atgtgtgata caacaaaaaa ggtgtcattt tttgaagatg 3562801 cgataaagcc aataaagaat gaaaaagctt gcgattgtga tggcttcagc cgagacgata 3562861 taccacggcc atggcccgag aacatctaag agagaggaac cgcccggttt tttcgtcaaa 3562921 tacatataat tcgcgccaag ccagcgatca atcagaaaaa tacagacgcc gtacacatta 3562981 acaagcagga ctgtcaccca taacgagcgc tggcccattc tgtaggtgcc aatcacagcc 3563041 atcagcagac aggataaaaa cacagacccg tgagaaataa aaaagaggat atatcggata 3563101 tgcggaaatg aaaacatacc gaggtcagga gtggcaagag cctgaatcga actgccgatg 3563161 ccgacaaaaa acaaaaacac aaacagcttt ctgctttttg tcactaacat aatagctgac 3563221 aaatacaccg acaggtcact aagctggaga ggcaatgaag tgcgcaccga ccacctgtcc 3563281 gtggcgacca tccatatttg atagccgatt tgcgaaccaa gcaaaagaaa cacaaacaga 3563341 gaacgcaaaa accggctggc cctcggctgc ttgacctcat cttggaacaa aaacaacaga 3563401 atggccaaaa gggagataat cgctaacgtc actacatgct ctgtcgaaaa cagatgaaac 3563461 ggatcatgct tatagtcgga ttgaacatat ttttgcaaaa ctgcaccccc gttttcgggt 3563521 ttttgtttat tttggcgttg tttgggcttt ttttattcaa ccgatatatg ggcttgaagt 3563581 tcacaccaga ctctgttaaa attcgtttca tagctaatga ttctgataat ttaaggcagg 3563641 cctaaaaaat ggaacgttca catcaacatc agcagcttcg gaaggaagaa cacgatacac 3563701 tttctaagct caaacaaatg cccgtcgagt cactcaacct ggaagccatt tcgatcgcta 3563761 cgaatctgta tcggtctgca caaaggctcc gtgtcaaaat ggagactgag gttctttcta 3563821 cctataacct ttcttggacc gctttctcca ttctttatga tctatgggta tggggagcgc 3563881 tcgaaacgag aaaaatcgct gagctgtcag ggatatctac agctacagca agcaacgtga 3563941 tcaaaacgct cgaaaaaaag agtttttgcc gtaaaagcat cgacacaaga gatcggcgac 3564001 tcgtgtttgt ctcaatcacc gattccggca aacaagcgat cgaagaactc tacccggagt 3564061 ttcacaaagg ggaaacagag ctcattgcgg gaatgacgaa ggacgaacag aaaatattga 3564121 cagggctgct tagaaaggta gctgacaatc ttcatacaac ataagctttg acgggaatcc 3564181 agtagcggtt tgtctccctg tttcagagag ccggcggtag gtgcgagccg gcgcacaggc 3564241 aaacgtgaat tacctcccca agctttcttt gtgaacctta gtagcaaaga acgggaaacc 3564301 gttattcgaa tgagcggaag acaatgtctt caaccagggt ggtaccgcgt gcattgagcc 3564361 acgtccctta ttgggatggg ctcttttttg tgtttgtaaa aaaggaggaa aaatgatgag 3564421 aacatttgag cagctcacag cgtcacaaca aaaagaggta gaaagacagc ttcagctata 3564481 catgacaggc gcccacgaag tcataccgcc ggaggaatta aaggcaaagc tcgtgaaatc 3564541 aatttccacg ggcacgccgc ttaaaattaa gctcggatta gatccgtctg caccggatgt 3564601 acatttgggc catacggttg tgttaaataa gcttcgccaa tttcaagaaa acggccacat 3564661 tgtccagctg ttaattgggg atttcacagg aaaaattggt gatccgaccg gaaaatcggc 3564721 agccagaaag caactgactg atgaagaagt tcagcacaat gccaaaacct actttgagca 3564781 attcggaaaa gtgcttgatc cagaaaaagt cgagcttcac tataactcaa aatggctgaa 3564841 aacattgaat ctagaagatg tcattgaatt agcagggaaa ataacggtag cccgcctgat 3564901 ggagcgcgac gactttgaag aacgcatcgc catgcaaaaa ccaatctcac tgcatgaatt 3564961 cttttaccca ttgatgcagg gctatgattc tgtcgttctc gaaagtgata ttgaattagg 3565021 cggaacggat cagcatttca atgtcctcat gggacggcat ttccaagaac gatacaacaa 3565081 agaaaaacaa gtcgtcatcc ttatgccgct cttggaaggc ttggatggcg tcgagaaaat 3565141 gtcgaagtcg aaacacaact acattggcat taacgaacat ccaaacgaca tgtacggaaa 3565201 aacgatgtca ctgcccgaca gcctgatgaa aaagtacatc cacttggcga cagacttaga 3565261 gcttgaagag aaaaaacagc tcgtaaaaga cttagaaacc ggcgccgttc atccgcgtga 3565321 tgccaaaatg cttttagcca gaacaatcgt ccgaatgtat cacggagaga aagcagcaga 3565381 agctgccgaa cactcgttta aaacagtctt tcaggaaaac agcctgccgg aagatatacc 3565441 ggccgtaaac tggaaaggcg aaaaaacgat agcgatgatt gatctgctcg tcaagctaaa 3565501 gctcctctct tcgaagagcg aggcgcgccg catgattcaa aacggaggtg tacgcatcga 3565561 cggagagaaa gtaacagatg ttcacgccaa agcagagata agagagaata tgatcatcca 3565621 agtcggcaaa cgcaagtttt taaagctcca ataatctgat attccgaaac gcttatgacc 3565681 cttcattcat aagcgttttt ttgcaggtat aaagcactgt cttttcaaaa acgctctcca 3565741 tcttgcagga aactccttta gcatcccgaa atattcccca accatacatt taggggaggt 3565801 ttatttttga tgaaaaagct tttgactgtc atgacgatgg ctgttttaac tgccggcaca 3565861 ctgctcttgc cggcacagag tgtcacccct gccgcgcacg ctgtacaaat atcaaatagc 3565921 gagcgcgagc ttccattcaa agcaaaacat gcgtactcta ccatttctca gctaagtgaa 3565981 gcaatcggcc ccagaatagc cggaactgca gctgaaaaaa agagtgccct attgatcgcc 3566041 tcatcaatga gaaaattaaa gcttgatgtg aaggttcaac gattcaacat tcctgaccgg 3566101 cttgagggta cactgtcttc agcaggacgc gatattcttc tccaagcggc gtcgggctca 3566161 gctccgactg aggaacaagg gctgacggcc ccgctttaca atgcgggatt gggctatcaa 3566221 aaggacttta ccgctgacgc caagggcaaa atcgccttga tttccagagg agacctgact 3566281 tattacgaga aagccaaaaa tgccgaagcc gccggagcga aagctgtcat catttataac 3566341 aacaaagaaa gcctcgtgcc tatgacgcca aacctgtcgg gaaataaagt cggcattccg 3566401 gtcgtcggca ttaagaaaga agacggcgaa gcacttaccc agcaaaaaga agccacctta 3566461 aaactaaaag cattcacaaa ccaaacctcc cagaatatca tcggaatcaa aaaaccaaag 3566521 aacatcaaac atccagacat tgtgtacgtg accgcccatt acgacagtgt tcctttttcg 3566581 cccggagcaa atgacaacgg ctcaggtacc tctgttatgc tggagatggc gcgtgtctta 3566641 aaaagcgttc catctgataa agaaatccgc tttatcgctt tcggcgccga agagctcggc 3566701 ctgctcggct cctctcacta tgtagatcat ctatcggaaa aagagctgaa acgaagcgaa 3566761 gtgaacttca acttagatat ggtaggcaca agctgggaaa aagcgtctga gctgtatgtc 3566821 aacacattgg atggccaatc taactatgtt tgggaatcca gccgtacggc tgctgaaaaa 3566881 attgggtttg acagcctgtc tctgacacag ggaggatcat ctgatcatgt gccattccac 3566941 gaagccggca ttgattccgc taactttatt tggggagacc cggaaacaga agaagttgag 3567001 ccgtggtatc atacccctga agactcgatc gaacatatca gcaaagaacg cctccagcaa 3567061 gcaggcgatc ttgtgacagc cgctgtctat gaggctgtga aaaaagagaa gaaaccgaaa 3567121 accattaaga aacaaatgaa ggcgaaagca tctgacattt ttgaagatat caaataaaaa 3567181 aagacggcac ttgggtgccg tcttttttaa tccacttctt tcttaatccc cagcattttc 3567241 tcatctaggt aatgggcaat ctccgcggct tctttcagct catctgttaa ttgcttagga 3567301 acgtcattgt tcaatttata ataaatttta tgttcaaggc tcgcccagaa atccatcgcg 3567361 attgtccgga tttgaatttc tgctttgacg tattccacac ggttcgttaa attcacaggc 3567421 atctcaatga ttaaatgcag gcttcgatag ccattcggtt tgggtgtctg gatataatcc 3567481 tttaccttta cgattctcaa atcttcatgc tgcttcaaca cattcacgac attataaatg 3567541 tcagaaataa aggaacagat gatgcgcacg ccggcaatgt cgtgaatatg ctccttcatt 3567601 tccttcgtcg taatctcaca gccctttctc attaacttat tcacgatgct ttcaaagctt 3567661 tttacacggg attttgtatg ttcaatcggg ttgtgtccgt gaatgaggtt atattcctgg 3567721 ctgataattg agaactttgt atcgagcgca tctagcgcaa atttataaac taataactca 3567781 tttttccaat cttccattac tgtttttaaa tcgtccatat gtgttacaga taaatccatg 3567841 ttcgtcatct cctttaacgg aactttatcc gctgtccatg tactagacgt ccctgtctgc 3567901 tgcaaggttc tatgaatttt tttacaaaat gcggtcgatt gtaacaaaaa aagaccgcat 3567961 gaaacgagcg gtctttttta ttatcggaaa tagctgatca ataatccgat cgagagcagg 3568021 aatccgaaaa atgtatttgt ttgggctgtt gatttcattg cgacaatcat attcatcggc 3568081 atttcgttct ggacgaagcc cttcactgcc tgaaccggct taggcacgct caaaaagacg 3568141 acaaacagcc atgggcttgc ggcaccggta ataaccaagc cgacaaccca gatataagcg 3568201 acggcaaacg acgcagctaa cagagtaaca gctcccttat gccccatcaa aatcgccaat 3568261 gttttgcgtc cgcctttttt gtcctcttca atatcacgaa tgttgttcga caggttaatc 3568321 gcgccgacaa gaatcgcaat cgggatggaa atcaaaatgc tctgcatatt gatcttatct 3568381 gtctgaatga aaaacgaaat cagcacaaac accgaaccca tgcaaatgcc tgagaataat 3568441 tcaccgaacg gcgtgtacgc aatcggcagc ggcccgcctg tatacaggta gccgatcgcc 3568501 atgccgacaa ggccgatcag cgcaagccac cagctgctgc tggcacaaat atagacaccg 3568561 agcaaaatgg caatcccgta tgaggcaaga gctaattgca aaatcgtttt aggcttcatt 3568621 ccgtggcgta caatggcccc tccgattccg actgattctg ctgtatctaa tccgcgttta 3568681 aaatcatagt attcattaaa taagttcgtc gcgatctgga tccataggca agaaaacagc 3568741 atagccaaaa acagcagcag atcaaccttc acataaaaca tcgccaaaac ggttccgagc 3568801 agcacaggca caaacgatgc ggttaacgta tgaggacggg ttaactgcca aaggatctgc 3568861 cccatgcttt ctttttgcgg cgctgtctga ccctcaccct tatttgtttg gttcatcttc 3568921 ctcttccttt ctattaaaag gcttactttt tttcagccgg cagcttaata aaaaactcct 3568981 tttgcttcct tatctatcat aatgacttct cccttatttc acaagatacc gcaagaaggc 3569041 gttttctttc ttattatacg cttctcgccc tgatttcatt aggtttctgc tttcacttga 3569101 acgaacaggt acagaaaaat ttttttaagt acattacact ttttaaaagt taaaaagatc 3569161 ttttgactcc aggtatcttt tcctttatta tgaatcagct cgaaacattc cattcttgcc 3569221 cttgcaggta taaagattca ttttcaaaaa catacgccga tatattaatt tgagggagat 3569281 tagggaaaaa atgaaacttt ttgagcatct gatcgtcaaa taatcatgtg attgtcgaaa 3569341 aaacgggaag ggaatttttg atatgctgca attaatgaaa cagctgtatg aaaaacccgc 3569401 tgtcaagtgg acatgtcata caggctttta tttgatgata ctgcttgttt tgttttttat 3569461 gtatggtttt cacaccgcga ataccggttc atatatttat aacgatttct aattggagag 3569521 agaataacta tgaaactttt acatgctatt caaacacatg cggaaactta tccgcaaacc 3569581 gatgccttcc gctctcaagg ccagtcgctc acgtatcagg aattatggga gcagtctgac 3569641 cgcgcggctg ccgcgatcca aaaacgcatt tctggggaaa agaaatctcc tatccttgtg 3569701 tacggccaca tggagccgca catgatcgtt tccttcttgg gaagtgtcaa agcgggacat 3569761 ccttatattc cggttgacct gtctattccg tccgaacgga ttgcgaaaat tatcgaaagc 3569821 tctggagcag aattgctgat ccatgcagca ggactctcaa ttgatgcagt cggccagcag 3569881 attcagacag tttctgcgga agaactgctg gaaaacgaag gcggctctgt cagccaagat 3569941 caatgggtca aagaacacga aacgttttat atcatttaca cttccgggag cacaggaaat 3570001 ccgaaaggcg tgcagatttc cgctgcgaac cttcaaagct tcacagactg gatttgtgca 3570061 gactttccag tcagcggagg aaaaatattt ttaaaccaag cgccgttctc atttgatttg 3570121 tctgtcatgg acctatatcc gtgccttcaa tcaggcggga ctttacattg cgtgacaaag 3570181 gatgctgtga ataagccgaa agtcttattt gaagagctga agaagtccgg gctgaatgtg 3570241 tggacatcaa caccttcctt tgtgcaaatg tgcctgatgg atccgggttt ttcacaggat 3570301 ctgctgcctc atgcggacac atttatgttt tgcggagagg ttcttccggt ttctgtggcc 3570361 aaagcgctgc ttgagcgttt tccgaaagcg aagattttta atacgtacgg cccgactgaa 3570421 gcgacagtgg ctgtcacatc ggttgaaatt acgaatgacg tcatcagccg cagcgaatcg 3570481 cttccagtgg gcttcgccaa accagatatg aacattttca ttatggatga agagggacag 3570541 ccgcttcctg agggagaaaa aggagaaatc gtcattgcag ggccgagtgt aagccgaggc 3570601 taccttggtg agccagagct gacggaaaaa gcgtttttct ctcatgaagg ccagtgggca 3570661 taccgaactg gcgatgccgg ctttattcaa gacggtcaga ttttctgcca aggacgtttg 3570721 gattttcaga ttaaacttca cggctatcga atggagctgg aggaaatcga gttccatgtc 3570781 agacagtcac agtacgttcg ttctgctgtc gtgattcctt atcagccaaa cggaacagtt 3570841 gagtatctga tcgctgctat tgtgcctgag gagcatgagt tcgagaagga attccagctg 3570901 acaagcgcta ttaaaaaaga gcttgccgct tctcttccgg catatatgat cccgagaaaa 3570961 tttatctatc aggatcacat tcaaatgacg gctaacggca aaattgaccg aaaacgcatt 3571021 ggcgaagagg ttcttgtatg acgccttaca gctcgttttt attctttata ctgcttggca 3571081 ttcttcttct gccgacgatc attctcggct taaacggaaa aagatttcaa gcatacaaca 3571141 tgttcatatc tatcattata ttggctttaa ttttttcgca cgacttacac ggggtcatcg 3571201 cgctgtgcct gtttacaata tggcaggtgc tcctgatcag cggctatctg gcataccggc 3571261 agaaagcgaa cagcggcttt gtcttttgcg gagctgttat cgcgtctatt ctgcctttat 3571321 ttctgtcaaa aatatggccg tttctttcac acccgcagcc gcatcatccg ccgcataacc 3571381 tgatcagctt tttagggatt tcatatttaa cctttaaagg cgttcagctg attatggaag 3571441 caagagacgg actgctgaaa gaacagctgc cattgcaccg tctgctgtat ttcatcctgt 3571501 ttttcccgac gatttcctcc ggcccgatcg acagataccg ccggttcgtc aaggatgaac 3571561 agaaggcttg gacgaaagaa gaatacgccg acctgctgta tacgggaatc cataaaatct 3571621 tcatcggttt cctgtataaa tttattatcg gctacgcgat caatacgtac ttcatcatga 3571681 atcttcccgc aatcacgcac aataagattc ttgggaacct gctgtacatg tacggctaca 3571741 gcatgtattt attctttgat ttcgccggct acacgatgtt tgccgtcggg gtcagctaca 3571801 ttatgggcat taaatcacca gaaaacttta ataaaccgtt tatcagtaaa aatattaaag 3571861 atttctggaa tcgctggcat atgtctctgt cattttggtt cagagattat gtgtttatga 3571921 gattcgtatt ttggatgact aagaaaaagt ggatcaaaaa ccgtatggcc gtctcaaaca 3571981 tcgggtattt cctgctgttt atgctgatgg gggtttggca cgggctcgcg ccgcaatata 3572041 tcatttacgg cctctatcac gccgttctga tgacgtgtta caactttttc gagaagtgga 3572101 ataagaaata taaatggctg ccgtccaacc gctggacaac cattctcgct attgtgatca 3572161 cattccattt cgtttgcttc gggttttata ttttctcagg aaaaccattt catcaccacc 3572221 attaaaggag attagaaagc tatggatttt aaacaagagg tattagacgt tttagcagag 3572281 gtttgccagg atgacatcgt aaaggaaaat cctgatattg aaatttttga agaaggtttg 3572341 cttgattctt ttggaacagt agaattgctg cttgcgattg aaaaccgttt tgatatttta 3572401 gtgccgatca ctgaatttga ccgggacgtt tggaatacac ctaacaacat tgtaaatcag 3572461 ctgtctgagt tgaaataatg aaaaagcgtt ttttcggtcc aattattttg gcgtttattc 3572521 tattcgcagg cgccatcgca attccatctt catggctgac aggcttcatc accgataagc 3572581 gtgtgaaaga gtcagcaaca gccttgaatc cgagtatgtt tcaagggcta tatttacaag 3572641 atcagatgct caaagatccg acatatcttc cgatttacgg gtcttctgag ctttctcggc 3572701 tggacgagtt ccacccatct aattattttc aggtaaacaa tgagggattc acgccatacc 3572761 ttgtcggcaa aggcggatcc cagtcattga ttcattcttt aaacttcgct gcccacatgg 3572821 atcagctgaa gggcaaaaaa atcgtattca tcgtgtctcc gcaatggttt attaagcgcg 3572881 ggtctgatga acagcatttc gcgccgaact attctgcgct gcaagggctt gatttggcat 3572941 ttaacgatca gatcgatcct gaaattaaaa agaaaatgat gaaacgcatg cttcgcttta 3573001 aggctgtgca aaacgatgcc attctttctg agctgtacaa agcaatggta aacggtcaga 3573061 cgtggaaagt gaacgcgctg aagccggcgg cgaaagtgta ttacagcatg ctggaaaaga 3573121 aagatctgta ttattcaacg acagaatcat ccgggccaaa gcgctatatc tcgcagtcag 3573181 taaaggataa gtcatggtct gaattgaata aactagcgga tcaatcgggc aaacgccact 3573241 ccggttctaa cgattttcac atcgacaacc ctgtctataa aaagctgaag ccgaaagtgc 3573301 ctaagctgaa agggaaaaac aaaggaagat cgtatgcggt gtcaccggaa tatggcgact 3573361 ttgaaatgat gctcgatatc ctgaaggatg cgggcgcaga gcctatgttt gtcaccattc 3573421 ctgttaacgg gaaatggtac gattacacgg gcttcccgaa aaaaggacgc actgactatt 3573481 acaaaaaggt aaataaacaa atcagagcga agggcttcca ggttgctgat ttctcagggc 3573541 atgaatatga cccgtatttc atgaaagaca ccattcacat cggctggaaa ggctgggtgt 3573601 atgtcgataa agcaattgac gaattttata aaaccggaaa agtcacttca tcctgagcat 3573661 ctcataggac gcggctgcat atttcctgct aagatttgta atagtaaagg aatcacagcc 3573721 aacttaatta agaggtgtta catccaatga agatgacaaa taatacggtt ttaatcacag 3573781 ggggttctgc tggcatcggg cttgaactgg ccaagcgcct gctggaactt ggcaatgaag 3573841 ttatcatttg cggacgcagc gaagcacgtc ttgcagaagc gaagcagcag ctcccaaaca 3573901 tccatacaaa gcaatgtgat gttgcagacc gttcgcagcg ggaagcattg tatgaatggg 3573961 ctttaaagga atatccgaac ttgaatgttc tcgtcaacaa cgccggcatt caaaaggaaa 3574021 ttgactttaa aaaagggaca gaggagcttt ttgtggacgg tgatgaaatt gaacttaatt 3574081 tccaagcgcc tgtccattta tccgcccttt tcacacctca tttgatgaag cagcccgagg 3574141 cggcaatcgt tcaggtcaca tccgggcttg cgtttaaccc gttagctgtt tatccggtgt 3574201 actgcgcaac aaaagcggca cttcactcgt tctcgcttac gctcagacac cagctccgcg 3574261 acacgagcgt ggaagtgatt gaaatggcac cgcctatggt ggacacgggc ttaaaccaaa 3574321 aatcacgcga taaacaaggc ctgacgtacc ggggcatttc atctgaagaa tatgttcaat 3574381 atttcttgga cggcttgaag gaaggcaaac aggagattac aaatgaacgt gttgaaggtc 3574441 ttcgggatgc cactcgcgcc gattatgaca ggttattcga gcaaatgaac acgcaggaga 3574501 attaatttct cctgcttttt tcatatgaat ttcttacaaa tttgagcaaa cctattgcga 3574561 ttatttgttg aaggtataca atagaatata attattttca aataagtttg ataatataaa 3574621 caatttaaca gcagggagat tgaccatgac taaacaaaca attcgcgttg aattgacatc 3574681 aacaaaaaaa ccgaaaccag acccaaatca gctttcgttc ggaagagtgt ttacagacca 3574741 catgtttgta atggactatg ccgcagataa aggttggtac gatccaagaa tcattcctta 3574801 tcaaccctta tcaatggatc cggctgcaat ggtctatcac tacggccaaa ccgtgtttga 3574861 agggttaaag gcttacgtgt cagaggatga ccatgttctg cttttcagac cggaaaaaaa 3574921 tatggaacgc ctgaatcaat caaacgaccg cctctgcatc ccgcaaattg atgaagaaca 3574981 ggttcttgaa ggcttaaagc agcttgtcgc aattgataaa gactggattc caaatgcgga 3575041 gggcacgtcc ctttacatcc gtccgttcat catcgcaacc gagcctttcc ttggtgttgc 3575101 ggcatctcat acgtataagc tcttgatcat tctttctccg gtcggctctt attacaaaga 3575161 aggcattaag ccggtcaaaa tcgctgttga aagtgaattt gtccgtgcgg taaaaggcgg 3575221 aacaggaaat gccaaaaccg caggaaacta tgcttcaagc ttaaaagcgc agcaggtagc 3575281 cgaagagaaa ggattttctc aagtactctg gctggacggc attgagaaga aatacatcga 3575341 agaagtcgga agcatgaaca tcttcttcaa aatcaacggt gaaatcgtaa caccgatgct 3575401 gaacgggagc atcctggaag gcattacgcg caattcagtc atcgccttgc ttaagcattg 3575461 gggccttcaa gtttcagaac gaaaaattgc gatcgatgag gtcatccaag cccataaaga 3575521 cggcatcctg gaagaagcct tcggaacagg tacagcagct gttatttccc cagtcggcga 3575581 gctgatctgg caggatgaaa cactttcgat caacaacggt gaaacaggag aaatcgcaaa 3575641 aaaactatat gacacgatta caggcattca aaaaggcgct gtcgcagacg aattcggatg 3575701 gacgaccgaa gtcgcagcgc tgactgaaag caagtaagaa aaaagccggc ccattacagg 3575761 ccggcttttt ttacgcttca attttgttga aaaactgcgg cagatacgct ttgtgcgcct 3575821 ctagcatttc gtctaaaatc tgtttggcca cagtatcgga cgggacaagc gggttaatcg 3575881 tcatggcaag gagcgcagtt tgatagtcac ctgtaactgc cgcttctgcc gcgacacgtt 3575941 caaaggattt gatttgctgg acaaggccgc ggacagacac cggcaagtcg ccgacagcaa 3576001 ttggcttagg gccggttttc gtcatcacac agttcacttc aactgcggaa tcgtctggaa 3576061 tactcgctat tgcaccatta ttgatcgtgt tcaccggctg aatgtcatgt ttatcattat 3576121 aaatggagct gattaagtta catgctgcat cactgtagta agctccgccc cgtttttcca 3576181 gctgcggcgg tttgatcgca aggtttggat ctttataaag ctcgaacagc tctttttcga 3576241 ccttctgtac gacttcagcg cgggtgccct ccgtttgtga tgcttccagt tcgtgctcca 3576301 gcatctcttt tgttttaaaa tagtaacggt gatagccgca agggatgaca ttgagcgctt 3576361 ttaagaaatc cggttcccat tcggcgcctg agatattttt catcgtcatc gcgtttttcg 3576421 ggtcgcccat cgcctcgatg acttgctcct tcacacttac gccgtccaag aaaacatcca 3576481 gcccgaatac catatggttc agtccggcaa attggacttc tacgcggtcc acatctacat 3576541 caagcgcttt ggctacgccc attttgatgc cgattggaac attgcaaaga ccgacgactt 3576601 tcttcaggtt ggagtagcga agcaaggctt ctgttaccat gccggcaggg tttgtgaagt 3576661 taacaagcca agcgttcggg caaagctctt ctatgtcctt tgcgatctca aggatgaccg 3576721 gaattgtgcg caatccttta aacagacctc ccgggccgtt tgtttcctgg cctatcactc 3576781 cgtattttag cggaatgcgc tcatcctttg ctcttgcctg caaaagtccg acgcggaatt 3576841 gggtcgtgac aaagtctgcg tctttcagcg cctttctccg gtcgagcgta agatgaatgt 3576901 caatcgggac gccagctttt tcaaccatcc gtttggcgag tgtgccgaca atattcagct 3576961 tttcttcgcc ctcggggata tcgacaagcc ataattcacg gacaggcagc tcatcatacc 3577021 gtttaatgaa cccctccact agctcgggcg tatagcttga acctccgcca atcgttacaa 3577081 tcttcaatcc ttttgtcata tgcttgctcc cctttgctcg gtgatttttt catataactc 3577141 aatgatctct gcagccatat ccttcactgt cattgcattc attaaatgat cctgtgcatg 3577201 aaccatcaga agcgtcattt ccgtcttttc tccgcccgct tcattttgga tcagctctgt 3577261 ctgataatga tgggcttttg acaattcttc agcagcgtct tgaagctttt tccgcgcttc 3577321 ttctgcgtca ccgcttttcg cagcggcaat ggcctccatt gcggagctcc taccgtttcc 3577381 tccgtgaagg atgatttgaa aaatgatttg ttccatttcc tcattcacgc gattcacttc 3577441 ctttctctac agagccgctt ctttgtcatc tgttgctgca ggcgtttgga ccagctccag 3577501 atcgttttct tctttcagct tctgcttatc ccacattctg aagaatggat agtagacaac 3577561 aaaggacacg gcaatattaa tggcttgcat gaccgcgcct gagacttttc ctcctgtcgc 3577621 caagtagcct gaaaagatcg gcggcatggt ccacggcact gcgatacccg ccggtttggc 3577681 gacaaggccg gtgctcattc cgatgtacgt gagtgtcact gtgacaagcg gcgtgatgat 3577741 aaacggaagt aagagcattg ggttcatgac gatcggcatt ccgaatataa tcggttcgtt 3577801 aatattgaag atggccgggc cgaccgcaag cttcccgagc tgcttcattt gtttgcttcg 3577861 ggcgcgcagg aacatcgtga caaccagtgc caatgtggcg ccgcttccgc caatattgac 3577921 ccagatatcg aaaaattgct gggtgaaaat cttaggaagc tcctcaccgg cttggaatgc 3577981 gatccggttg gcatccattg cgccgtacca aatcggtgcc atgacgccgc caacaatgtt 3578041 tgcaccgtga aggccgcagg cccataaaag cattttgacg gcttcggcga caaggcttcc 3578101 tccaaggctt cctcccagaa tggaaagcgg agtccccaat aaaacgctta caatattatg 3578161 aaggctttca aacggtgtcg cttcaacaat cagccgggct gcccaaatta ggaagatgac 3578221 ggcaaagccg gggattaacg cgacaaatga cttgcttacc gccggcggga caccgtccgg 3578281 cattttgaag actaaattgc gctggataat aaggcggtaa atctctgtgg acaccattgc 3578341 gataatcatg gcgacaaata agcctttgct tcccatgagc gaaagcggaa tcccgccgcc 3578401 aaccatgatt tctttcgtcg cgccatccgg cataaacggc acttgataag gtgttgctaa 3578461 taaaaatgcc gcaagggaaa tggctccggc cgacaaggca tcaacaccgt atttctcggc 3578521 gagccggtag gcaatgccga acgcggcgac aagacccata atttcaaagg tcgcgtcgac 3578581 tgggtaggcc agtttttcag accaggagct gccaaacgtt tttgccataa actcagcgta 3578641 tcccgggatc gggaggttgc caatgatgag gaaaaaggaa ccgatgataa tcaggggcat 3578701 cgtgaggatg ataccatcac gcagcgcctg caaatgacgc tgtcccgcaa ttcttcccgc 3578761 tataggcatg accttttctt ctaagatctg attgacttta ttcacatagc ccgcccctct 3578821 ctatgacaca tgtccaagct gttcagctga tttcagcact tccgccccat tgcacgttcc 3578881 ataatggacg gtattaatga cgtctaccgg aacccccttt gactctccta attttttgag 3578941 ctgcggaagc atgtaacgga cttgcggacc gagaagcaat acatccgctt tatcgatatg 3579001 attttgtaca gaatcgcctg aaactgccca aatggtatag tcttttccct gttcctgcgc 3579061 acttttttcc atcttgctca ccagtaagct agtagacatg cctgctgcac aaacgagtaa 3579121 tatattcatg taaaagaccc cctagagttt gatcaatttt gtaatgtcct gctgttgcta 3579181 tcatcatatt atgaaatcgc tttcataaac actcagggtt tttccgcagg caacggaaaa 3579241 aaggtatata caggctgtca gctcagcatt ttttggtcaa acacatccga aagctcttga 3579301 tatgaacggc atttgatcag ctggttcatc gccgccgggt catccaaaat gctgccaagc 3579361 agtttataca tgctttgtaa atccgctttg ttctcctttt cgacacaaag cagacagaca 3579421 aattgaactc gctgactctc ccaatcgatc ggttttttga gcgtacaaac ggcccaaaac 3579481 gttgttttcg tctgcggaac aagcgggtgc gggatggcaa caagattgcc aaaacacgtt 3579541 ggcgacatgt cttctctttc aaaaatggaa tctatgattt cttcatcggc aaagccgcat 3579601 tcgaccactt tctgccctaa aaattgaatc acttcttctt ttgagcgcag atcctcctga 3579661 aaaaaaacga gttctttttt taggtagcga ttggcttttt ccttttcatc actcagaata 3579721 gattctattt ttgtaaagtc agttccgcct aagatggtgt taaccttcag tactggtaca 3579781 gggagctctt ttttaatcgg aatggtgctg atgacaaaat caattgattc gtaggacatt 3579841 tgatcaagac tataatactc agccgttcca agaatatcga gccgcttgcc gaaatgggaa 3579901 cgcagttttt cgcgcagaag ctgggcgctt ccggctcccg atgcgcatac aatgatacag 3579961 cgtttcggcg ggctttctgt tttttttcgt tcaatcgcgg cgccaaagtg gagagccaaa 3580021 tatccaattt cgttttcatg aatctcaata cccgtttgtt cctttatcac gattccggca 3580081 atgatcccgg cttcaaaagc gagtggataa tgttccttga tcgctgccag catcggattt 3580141 cgaagattca tgccgtatcg gttgcggctg atcgccggct tcatatgcag tgccaagccg 3580201 attttcagct ctttgtcatg caggatgcca agcttcagtt cacgatcaac agctttgatc 3580261 atggcaagtg tcagctgatc ggtttcctct tctattgaaa atgtgtcctc tccgcattgt 3580321 gattgtgtca ttcgttttgt gccaaggaga tgcatggtga tgtaggccgt ctcgtctttc 3580381 ggaaacgtaa cggaaagctt tgattccagc tcttttacga tggcttctgc agcctggtac 3580441 tccttttgat gcaggatatg atccatatct ttcgggaaaa gagaaacata gttttccgtt 3580501 ctgatccgtt tacaggcgat agcgatatgg ataatgaggt tattcagtcc catgttggac 3580561 agagggatgc ggtcgttttt catttttttc aagatggcgg aacggatgat ctcaatttct 3580621 tcttttggca aaatatcagc cttttcattt aaaacatcta tctccgtttc tctttcatca 3580681 acaatgtact ccgccatgca gtacctcatc tgcacctcgt ccccgcgcag cttgaagccg 3580741 taattcggac gtgtttccat gacgatgcgg taaggcagca gacgtttctt tacttccttt 3580801 aaatccgttt ggagtgtaga ttttgagata aatagttctt cagcaagttc atcgagcttg 3580861 agataatggt ccgccagcag cagacgtttc ataagatagg ccattctctc ctccggcaat 3580921 accggcaggc cctttttttg ctgaaattca tcttgcagca gtgttctgaa tacttgctcg 3580981 tcatcaatgc ggagcttgta gccggagcct cttacagatt gtacaaaggc accgtggccg 3581041 cttagcacac cttgaagttc ctttatatca ttgcggactg tccgcgtcgt tacgtttaat 3581101 tgcgcggcaa aaaacgaact tgtcaccggg gcttcagccg ccatcagcaa gcgcagaata 3581161 tcacgtagtc gcccatgaag catgagaaaa acctcctaac tagtagatgc agggattcag 3581221 tgaataggca gaaaggatga tgaagggatg cgaaatgtat ataaattcta taatggagag 3581281 aatggcaagt caatgaacat ccggaggact agagggaaaa ctgacctata aaaaaacagc 3581341 cgggatcagc cggctgttct agatgcggac atattctttt gtttagacgc cttgcggtcc 3581401 ttcatgattt ttcgaacaat cgggtaaatg accggcgccc atttgataac ggttttgatc 3581461 atctttttca aagctccgat tctcccttct tttttctcaa ccattcccct gattgcctct 3581521 tccttaaaca tgctaacgcg acacgtacct gtttcccgtc acccagaaac gccatggata 3581581 atcgcgtgcc tccccgctgt tgtcaatgcc gatgcgcggg ccggttgaaa ttgcttccgg 3581641 tgtgtacccg ctttcgatgt aaagcggctg ttccgtgatc cagcgtccgt agtcattcat 3581701 cgtgacgcca agcgctttcg tcagctttcc tggtccgttt gtccattccc tcggactcct 3581761 gcccggcctt ctctcctcca ttaacagctg gccttcatgc ggctcaatcg ccctgattaa 3581821 tactgcttgc gggacatcct cttccgccgc aacgacattc agcaatgtat gggtgtgcat 3581881 cacgtatgta tatacccgcc cagcttctgc aaacatgatc tcagtccgct tcgtccggcg 3581941 gttgttaaag ctgtgggccg ctctgtctcc agcccccata taggcctctg tttccacaat 3582001 atagcctgac gctgtgcctt cgtctgtttc ttttacaaga aggcagccca gaagcgatgg 3582061 ggcaagctca agagcggttt tttgataaaa cgtgatgggc agcggatttt tttctctcgt 3582121 cacgaatcga cctctccttt taccgatttt tgtacattgt accattcccg aagcagatca 3582181 aaaaaaacgg ctgttttaaa atctttccat tcagggaata ttgttaccgt tcaaaaaagg 3582241 agggccaacc attgaaagat gatcatcaaa acaagcagca ccaatcaaat gcccaaggga 3582301 gcgaggaagc gttttctcat aagacatccg ggaaaaacga gtcagaggat accttaacga 3582361 ataggcaggg gcatcctgtt actgacaacc agaatgtgag aaccgtcggg aatagagggc 3582421 ctacaacact tgagaactat gattttctcg aaaagatcag ccacttcgac cgggaacgca 3582481 tcccagagcg ggttgttcat gccaggggag caggtgcaca tggatatttt gaagcgtacg 3582541 gaagcttcgg agacgaaccg atttcaacat acacaagggc caagctcttt caggaaaaag 3582601 gcaagaaaac accggcattt gtccgttttt caactgtgaa tcatggaaaa cactcgcctg 3582661 aaacattgag agacccgcgc ggttttgctg taaagctata tacagaagac ggaaactggg 3582721 atttggtcgg aaacaacctg aaaatctttt ttatccgcga cccgctgaaa tttccggatc 3582781 ttgtacacgc atttcagcct gatccagtga caaacatcca ggatggtgaa cgtatcttcg 3582841 atttcatttc tcaatctcct gaagcgacac acatgatcac cttcttgttt tcgccttggg 3582901 gcattccggc caactaccgg caaatgcagg gttcaggcgt acatgcctat aaatgggtga 3582961 atgaggaggg caaggccgtt ctcgtgaaat accattttga accgaagcag ggcatccgca 3583021 acctgacaca gaaggaagca gaagagattc aagggaaaaa ctttaaccat gccacacagg 3583081 atctatatga cgcgattgaa aatggcgatt atccagagtg ggaagtatat gctcaaatca 3583141 tgagcgatga tgagcatcct gaactggact ttgatcctct tgatccaaca aaactgtggt 3583201 ataaagacga tttcccatgg aaaccgatcg gcaaattggt tctgaacaaa aatccggaaa 3583261 actaccatgc ggaagtggag caagcttcat ttggaacggg agtgcttgtc gacgggcttg 3583321 atttttcaga cgacaaattg ctccaggggc gtacgtttgc ctactctgat acgcagcgct 3583381 accgtgtagg cgcaaattac ctgcagcttc cgatcaactc gccgaaaaag catgtcgcca 3583441 ccaaccagga aggcgggcaa atgcaatatc gggtcgatag agcagaagga caaaacccgc 3583501 acgtcaacta cgagccatcc attatgggcg ggctgaagga agcgaagcaa gacggaaaag 3583561 accatacgcc gcatgtcgaa ggtgatgtaa agcgtgaagc gattgacaga acaaacaact 3583621 tcggacaggc tggagaaacg taccggagat ttactgaatt tgagcggaac gaattgatta 3583681 cgaatttggt gaatacgctt tctacgtgcc gaaaagaaat tcaggatcaa atgattgaga 3583741 atttcacaaa agctgatcct gactacggaa aacgcgtagc agaagggcta aaaaaggtct 3583801 ccgaaaacaa cagcaacggg ccgatcggca caactgaaac ggaacaggct gcaaagcagg 3583861 ctgaacagga gagtcatccg tctgatccgt attaacaaca gcgaacaggg cttttttaga 3583921 agccctgttt ttttattttt ctattgaaac gctttcaata attgtgttgt acttggaagg 3583981 aaaggggtgg agagatacga tggaattaca gcaggacttg attcctcaga aaaaaacaat 3584041 cggcgcttta gatcacgccg tttttttatg catggtattt tgtttctggt tttcaggcta 3584101 tatttacgtt cctgtattca gtctgtattt ggaggatctg cacttttcat atggcgcaat 3584161 cggcatcatt ctcggcagct acggggtcac gcaaatcctt ctgcgattcc cgctcggcct 3584221 tttgtcagac atcctgtttt ccttgcgcaa gcaattgtta attgccgggt tcggcttttc 3584281 cgtcctcagc agcctgcttt ttctgatgtt tgattctttc ttcttcgtgc tggccgcccg 3584341 gcttttcgcg ggaatcactg cttctacgtg ggtgatggcg accattttat acgcacatta 3584401 tttcaacaat ggcaatgcat caaaagcaat gggcatcatg cagtttttta ccgtcatgcc 3584461 tcagtttgcc agcattgtgt tctgcgggct cgccgcagcc catttaggga ggcaggttcc 3584521 tttttggatg gcgctggcag cttctgccgc aggtctggtg atctgctgct ttattcagga 3584581 tccgtctgct cctcccgcaa accgtggcac cattcgtgtc aatcagtaca tcaaagatac 3584641 attgcggctg ccaaagctga agcttttcac catcctgtct atgacggccc atgccgtatt 3584701 atttatcaca gtgtttggtt ttacgccgct ttacatgaat cagctcggaa tgggcgacgc 3584761 ggagctgctt tgggtgatga gcgccttttt cctcccacac gcagccgcca cattaagctt 3584821 tgtgtttctg cgctttacaa gccgtatcgc ttactccgtg atgctcatta gtttcgctgt 3584881 caccggggtc tgtttgctat atgttccttt tttagctgca ttgttcacgg tttgcatcac 3584941 acacgcctgt attgggctgg cgctcggctt cgtttttcct ctgctgctaa gccatgtcgt 3585001 cgaaatcagt tctgcccgtt taaaaatgtc agtgatgggg ttttaccaat cattttatgc 3585061 gctaggcatc ttcctcgggc cccttcttgc cggaaaaatc gcacagctta tcgggcttgc 3585121 gggagttttt tatggagccg gttctctggc atttgccgcc ttttttgtga tgctcgcgca 3585181 aaaacgtaac atgatcaatt aatagctttc ataccgccgg aagcgccaca cagaaaacac 3585241 ggccagaagc atgatgcaca gaatggagaa agtgagtgac catccgaaaa aatctgcccg 3585301 ctctccatga agaaggatat gctccgcctg cttgcaaatc tcagccggaa gccacttcgc 3585361 accatctgga aatagtgaaa cagcaaagga aacggctgct gtgagcccga tcccgcaagc 3585421 cgcagctgct ccgacagacc ggaatatcgt acttccggca aggccggcgg tcacaataaa 3585481 tatcacccaa agagcgtaaa ggccaaggct tgcggcaaag cggctgaatg atgcgtcctc 3585541 aaacagcagc cggacgtaat agtaagcaag cccgtatcca gctgcaaacg acataatgcc 3585601 gatcacgctt tggatgagcc atttactcac gatataatgg gctgccgtca caggccgcga 3585661 cataatcagc gctgttaccc cttgatttct ttcattggct acactgccca tcacgctaaa 3585721 gatgaccaga gccatgccaa gcgtgttgaa ttgagaaagc gtgctgacca tcacttcaga 3585781 cccggagggc atcgtaaaac tgattttcat gccgtcagga aggttccctc catgtgcgat 3585841 gatttccggc atataataaa tggtcagcgg ctgtgtcagc ccgacgatca tcatcgcaat 3585901 cggcagccaa atcagcttgc cgcttttcca tccttccagc cactccttct gcaatagcgc 3585961 catcatcacc ttcatgcgtg caccaccttt agatagacgt cttctagaga ctccgttttc 3586021 tgttcaaagc gggtgacggt caatcccttt cggatacagt cacttaataa tgaccggcca 3586081 gcgtgtatat caggcagctc gaaaaccgct tgggacggat tcttatagac aatagctgag 3586141 acgtaaggct tctcttcaag ccaaccttcc agcttctctt tcactgaaag ggtaaaaacg 3586201 ttcgtttgct gctgttgttt cagctcctgt aactcgcctt tccatgaaat ctcaccgttt 3586261 ttcataatca ccacttgatc acacacctgt tctgcatcgt gcaaaacatg tgtagaaaac 3586321 agaacggcca tatgcttttt cagctcccgc atcatgtcca gcacctcgaa ccgtcctgtc 3586381 ggatcaagcg cagacaccgg ttcatccaat atcaaaaact tcggtttatg gagcagtgcc 3586441 tgtgccagac cgagtctttg tttcatgcct cctgaatagc ccccgatcct tttgtgcgcc 3586501 gcttcgtgca aaccgacaaa ttccagcatc tcgccgattt tctcttggca ttttctcttc 3586561 gaaaggccgg acagtctccc cgcaaatgtc aaaaattcat ttgcggtcat ccacgaataa 3586621 aaagcaggat actgcgggag gtacccaatc aaacgccgat ccagcttttt ctctcctaac 3586681 agctttatgg ttccagaggt tggcgaaagc agtccggcca gcatttgcag agtcgtggtt 3586741 ttgccggctc cattaggtcc taatagtgcg acacactcat tttcattcac gtgaaaactg 3586801 acattcttta cagcttcatg gtgcctgtac gatttgcata atgattcaat agacagcata 3586861 tcggcttacc tttgctttct gccgacggtg aaaaataaaa tcggcccgat aatattgata 3586921 catacgatga ttgcagccca catccacttt ggcccgttcg tccgctcttc ttttatacag 3586981 ctgataaggg caaacaccgc caaagccagc tgtaatacaa tcagcggcaa aatcatttcc 3587041 caagaaatat tcattgcttg atcccccttt tcttccgatc cggcctaatg acaaaaaagt 3587101 aataacaaat cagaggcatc ggtgcttgaa tcaatccgac aatcccccaa acccatgcca 3587161 tgtgattacg ttttttcgca tcaataaata aaaagattcc ctgcgccaat acgatgagac 3587221 aagccgcaac cgttatgata atttctgttt gtgtcatccg cgtttcacct cgcattcgcc 3587281 gagatgcctt tttttctcag ccgcaatcaa aatcggcagc accgcaagca cacaaacctg 3587341 aagcacaata aacacagcag gagcttgagt gaaagctaag attgcagcac tcacaaccat 3587401 cagcgcgcag aatacaaata aaatgatctc ttgaagaagt ttttttctgt attcagcttt 3587461 catttgtgac agctggtgaa gcagttcttt ttgattcggt atagagggat tggctgtttg 3587521 atcaattttt ttccattctg actttaaatg atcagaaagc ttttctttat tcatcatccc 3587581 actcctttct gatttgctgg agccctttat gaactctgga ctttacagtg ccttctttga 3587641 tttgaagcat caccccgatt tcagcgtagg tatagccgta gtaatgcctt aataaaaccg 3587701 gtgtgcgcag tttagggtcc agctttgaaa acagatcgag cgtttcgctc cactctgccc 3587761 ctttcgccga cacgtcccac ttgatcttgc ggattgtttc ctccgtaact gtctgattcc 3587821 gtttccattc tctctttctc tttttctggt gatcgagata gagccgcgat gcaatggaga 3587881 tcagccatgt ggagaatttt gaacggccct gaaagcttct taaatggatg taccctttca 3587941 gaaaggtttc ctgaacaagt tcctcgctga gatcggggtg aagggaaagc tttaacaagt 3588001 atttatataa gaaagaatag tgatagtgga aaagggctgt aaacgcctcg tcgtttccct 3588061 ctttcgcctg ctggatcagc cgctgttctt cttgtgtatc caatgaccgt gatcccccct 3588121 tttttgtttt tctgccttat gagacgacac cggattcaaa agcgttcatc ttttttacaa 3588181 ttcttttcag ccattgacag atcaggcttc ccggccgttt ggctgcatat ccttatttgt 3588241 aaaccccctt atagtctgtt aagctatgac tttatgtcga tttcaaaaaa acatccaata 3588301 tggaggacga tgcattgaaa gtagaaaggc gaacgattga atatattccg aatgaagaaa 3588361 gacatggtaa agcgaaagat ttatttcccg tatggttcgg ggctaatatg catatcacca 3588421 cgttagtgac cggcacgatt cccgttgcaa tgggacttaa tctgttttgg agtgttgccg 3588481 ctattatttg cggaacctta atcggtgcca tatttatggc ttctcattcc gcgcaaggcc 3588541 ctcagctagg catcccgcaa atgattcaaa gccgtgccca attcggcgta atcggagcga 3588601 ttcttcccct cttcttagtc atgtttatct accttggttt cttcgcaagc agcacgattc 3588661 tggcggccgg aaccttaagc agctttgttc ccatcccggg atcatggagc attataggct 3588721 taagtgccgt atgtttttta ctcaccattt tcggccatga tttgattcac aaaatgcaaa 3588781 aaatcctttc ttggacctct tttgctgtat tttttgctgc aacgattctc atttttcaat 3588841 tgccgattcc ggcaggcagc tggatacccg gagcgattga tctgccaatt ttcctagtgg 3588901 cagtcagcgc agttgcgacg tggcagcttg cctacgcgcc gtatgttgcc gattattcaa 3588961 gatatctgcc agttaaaaca ccggcttcaa aaacattttg gtacagctat gcaggtacat 3589021 ctgtcagctc catctggatg atgctgctcg gcgcattgct gacaacctca cttcctgact 3589081 ttacggcaaa ctcaggcagc cagattgtcc aattgttcgg tcccttctcg tttattatgc 3589141 tgatcattgt gctatttggg caaatggcaa tcaatgtttt taacctgtat ggggctttca 3589201 tgtccacgac aacaacgctg gagccgtttc tgaaattaaa agtcacgccc aaagtcagaa 3589261 tcatcatgat cctgggtgtc acgcttgtcg gcacagtctt aagcctactg ggacagagca 3589321 attttatgga actgtttttg aattttatct ttttcatcag ttatttctta attccgtgga 3589381 cggcaatcaa tttagtcgat tactacttcg tccgccacgg aaagtatcaa gtcaaagcca 3589441 tgttcgacgt aaacgggcct tatggaaagg tcaattggat caccacaatt gcgttcgttc 3589501 tgtctatctt gctggaaatt ccgtttatca acacaagctt ttacatcgga ccgcttgcca 3589561 aaatgtttgg cggcggagac atcgcatgga ttatcggctt ggccgtgcct tctgtgcttt 3589621 actatgtatt aatgaaaccg cgtctgaaaa aacgggcggg gtatcaagaa aagctgtctt 3589681 ctctctgaag acagcttttt tatcattcaa atcgtttcca cacgcggggc aggatgtcag 3589741 atagctcatg agcgagcaac gtatgagcgg agtgctcgtc cgtccagagc tcggcgcacg 3589801 caccatgcaa atagaccgcg tttaatacgg cgtgctttgg atcttcatgg cagcagagca 3589861 tccccaatat catgcccgtc agcgtgtcac cggttccgcc cttggcgagc gccccgtttc 3589921 cggttggatt gagccagcag tctccatcag gaaacgcgat gacggtttgg tttcctttta 3589981 acacaatgac agtctgcagc tgagccgccc attcctttgc atattccgct ctttttttct 3590041 gcaattcgtt cacgggcacc cctgtcattc ggaaaaactc gcccgggtgc ggcgtgagga 3590101 tgacggggcc ctcccgtttc ggatatgtgc gcttcgccag cgctccggca tccaaaataa 3590161 caggacaatc agccgtaagc acatgatcga ctgcctgctg tacgctttcc gtttgcggaa 3590221 ggcccggtcc gatggcaatg gcccggtacg tctcttcaag ctgagcatcc gccgcctttt 3590281 tccagccgtc acgccaatag gtcgcctcgg gcaaaacagg aacaattagc gggattacgt 3590341 tttctgatgt accgatgaca agcttgccga gaccgctccg catggcccca agccctgcaa 3590401 gcagcgctgc tcccggcatg tcgtcacttc cagccagcag caaagccgta ccgtacgtgc 3590461 ctttatggct ctccgcatct ctttcaggaa gcgtggccct tacatgctct tccgtccaaa 3590521 atggaacatt catctctatc cctcctctgc tttcttttcc tatttttcct gtcccttttc 3590581 tttttcaaac aaaaaagaca gccttttagg gctgtctttt attttacagg aacatcaagg 3590641 tgatacaggc ggcgatatcg ttcgtttgcc gccagcagct cctcatgggt tccttccatt 3590701 tctgttttgc cgttttcgag aaatacgatt ttatcggctg cttccactcc cgcgagatgg 3590761 tgtgtaatcc ataaaatcgt ttttcctttc agcacctcaa acaccgtttc catcaattca 3590821 cgttcggtaa taggatcgag gccgactgtt ggctcatcga ggatgatgat cggtgtatcc 3590881 tgcagcaaaa tcctcgcaag tgcgatccgc tggcgctctc caccggaaaa acggatgccg 3590941 gtttcttgta cagaggtatg atatccgtca ggcaatgact caatgtagtc atgcagcttg 3591001 acctgctttg cggcgcggcg cacatcctcg tcgcttgctt ctccgtttcc gagcctgatg 3591061 ttgttcaaaa tgcttgtatc aaacaggtgc ggtttttgat ttaacacggc caccgcatcc 3591121 gcaatctgat cctttaacag cgctgtctcc actccgttta acgtcacaga accggagtcc 3591181 ggtttcaagg cgccttcgat taatgcaagc gatgttgatt tcccagagcc gcttcggccg 3591241 agcagcgcca ttttttctcc ttggcgcagc gtaaaggaaa agttgtgcag cacttggctg 3591301 ctgttgtcat aagaaaacgt cacatcacga aaggccaagg tgacatcttg aagatcgaga 3591361 atttgatccc ctgattcagt ttgtgacgcc tccggctgag gagccacatt gttcatgcgt 3591421 ctgatagaat cctgatagcc cggcacttcg cctaaggcat ccgaaagcgg caaaaaggct 3591481 tccgtcaacg gaaacaccac tagcacaaaa gcggcaatca tcgttttagc gagctcgccg 3591541 tccgcttgct gtcccgctgt ccaaaacagc atcagcaaaa taaggccagc gacaaggcat 3591601 tgcgcagcaa agtcccgcca tcttgtaaag cgttgttttt tccgttcaag ctcaaaccaa 3591661 tcacgttcct ctttttcata agcatcaata aaagcatgcc ggcgtccgct gaacatccag 3591721 tcgctgacac ccatcacagc atctgtcaga cggctgtaca gcacattccg tccgcttttc 3591781 agcttcgcat tcttcgctct cgtcacgagc aaagacacaa ccggaaacaa tacaacaaga 3591841 acaaacaaat acagcgcaag caatatggca aacggccaag agaagaagcc gagcgctatc 3591901 actgacacag catacaggag caaggctgag atcgcaggaa aaatcgtttt taagaaagca 3591961 tcctgcaaat gctcaatatc ctcagacaaa atgccgagca tatcccccgt gcgaaaacgg 3592021 gaacgcagca tcaaagcacc cggctcaagc atattgtaaa ggcggacgcg catgtcagat 3592081 acgattttca aaatgatgtg atggccgacg agccgttcca catatcgcga cacagagcgc 3592141 gcaatcccaa aggtgcgcac agcgacaatc ggcacataaa tgagcagaat gttttccggc 3592201 cttgtcgccg ctttagaaat caaaaaacct gaggtgaaca tgagaaaagc agcagaaaaa 3592261 atcgtcaccg cacccaaaaa gataaccaga acgaacaggc gggcattttg cttgatatac 3592321 ggcaaaatcc attcttcttt cttcatgctc tttcccccag ttgtgccttc acgagtttgg 3592381 tatacacacc gtttttctcc agcagttcat tgtgagtccc aatttccgca accctgcccc 3592441 cgtcaagcac gataatttcg tccatatcga gcatccagtg aaggcggtga gtcgcgagaa 3592501 agacgagctt atcctcaaat aaatccagca tcgtttcttt tatttcatat tctgtttcga 3592561 tatcaagatg ggcggtcggc tcatccagca gcaggatcgg acggtttccc aaaaaggcgc 3592621 gggccagcgc gacacgctgt gcctggccgc cgctgagcgc ccggccgcct tccccgatcc 3592681 gcccctctaa tccgtcagga aggttgttca ccagctccgt cagtcccgct gaggcagcag 3592741 cacgtgttgt atcctctgcc gaagcgcttg gatggtagaa gcgaatgttg ttgccaagcg 3592801 tatcatcaaa aatgtacgga tgctggggaa tgtaaagaag gttcttctgc cagctgccgt 3592861 cctgcaaatg ggaccggctt gtaccattaa cctcaatcat cccgccatcc ggctctaaaa 3592921 atccgccgag aatatcaatt aatgttgatt ttccggcgcc gcttgcaccg ataatgccga 3592981 tttttttctt gcctttgaat gagagatgaa tatcagacac cgaacggccg actgacacgc 3593041 ctgacagctt cagctcatcc tgatcggacc aagcttcgag ctgaagcggc gtctcttctt 3593101 taaaaccagg ctgcgacaaa atctcttgaa tggtttttcc tgcttcctgg ccgttcagcg 3593161 ttgcatgata atcattcccc acttcccgca ccggcaaaaa atactcaggc gccagaataa 3593221 gcgccgttaa agcagggcca agcaaaatat cgccgtcaat gaggcgcagg cccagaaata 3593281 ctgcgactgt cgccaccgac agcatcgtga aaaaatcgag ggcgaatgat gacaaaaacg 3593341 ccacccggag tgtgctcatc gttgccttgc gataccgctc actcacatag aaaatatttt 3593401 tgctgtgtga cttgctcaaa cctaggaaac gcaatgtctc cagcccgcga agagaatcaa 3593461 caaaatgatt ggaaagtctc tgataggatt tccactgacg atccgctttt ctctgcgcga 3593521 caaggccgag gagaatcata aagatgatca gaatcggcat agcagcgact aaaatgatgg 3593581 ctgatgtccg atcctgaaaa aacacataaa tgacaactgc cgcaggcaca atcgccatgc 3593641 tgaccatttt cggcagaaac agctccaggt agcggcggaa ctggctgatg ccttccatcg 3593701 ccagcgtcac catttgcccc gtcccctctt tctttgcaaa gcgggggcct aatcggaaca 3593761 gctgatcaag aaaacttttc ctcaaatctg ctcctgtccg ggcggcgtat tgatagacga 3593821 ttttctgtcg cgccaccgtc atcccgtgcc gggcgataaa agcgatgagg aaaaagccga 3593881 tcaccggtaa aagggaggta atgcccttcc cgttgaacag tccggttacg gcctcactca 3593941 gccactctgc ctgcataata atggcggctg tctgaatcaa cgttaaacaa gtaatcaagg 3594001 tgagaatccg cttcattcct ttatatcgaa acaggtcttt tcccattaat aagtcatagg 3594061 ctccttatgg ctgacgcgct tccggaagac ataatagctc cagatctggc tgccgatgac 3594121 gaacggcaat agcgttaatg ctgcaattga catgacttta agcgaataat ctccagaaga 3594181 agcgttagct actgttaaat cgtatgcgct atgaagcgag ctgaccatta cacgagggaa 3594241 tagggaaata aagatcattc ccacggtcag cgccagacca gcgcctgtca tcccaaatgt 3594301 ccagccgtct tttttcttac gaataaatac agccgcgagc ataaagcaga tgacaatcaa 3594361 aacagcgagc ggaatggtaa tctcgccgcg gcgtgtaaac atgtctgtct gatacgcaga 3594421 aagggccgcg aaggcaagaa ccgctacaaa aacaacaccc attatctttt gcgccatttt 3594481 ccgggcgcgg ttttgcaaat caccaatcgt acgcagcgtg ataaacatta atccatgctg 3594541 gaagcaaaga agcgttaccg tcacaccgcc aagtatagaa tatacattga tataatcaga 3594601 tacatgtgcg tgaatgttca tgtcggcatc aatcggcatc ccgcggaata atgtcgtgaa 3594661 cagcacacca agcacaaacg gaggaattag actgccgaaa aaaacgaccc agtcccaaac 3594721 ctttacccat tttaaatgat ccaccttgcc gcggaactca aacgcgaccc cgcggcccat 3594781 taacgcaagc agcactatga caaacggaat gtaataaccg ctcagcatcg ttgcatacca 3594841 gtttgggaat gccgcgaaaa tggcgcctgc gccagtcaaa agccacactt cattcgcgtc 3594901 ccagaacggc ccgatcgtgt tgatcagcac tctgcgttct aattcattat ggccaagaaa 3594961 acgggtcgcc atgccgaccc cgaaatcaaa gccttccaaa aagaagaatc ctacaaacaa 3595021 tacagcaacg agtataaacc aaagatcatg aagagatgcc atggtatacc tcctgactaa 3595081 atggatctgt tgatacaggc acatcatgat gattatcatg ctccgcacct tttttaatct 3595141 cacggataaa caagaagaca agcagtgcac caagaatcat gtacatcaca ccgaatgcga 3595201 tgattgagaa taacaaggaa cccgctgtta cgttaggcga cacagattga gcggttgtca 3595261 ttaaccccat aaccgtccaa ggctgacgtc cgatttctgt cataatccag cccgcggagt 3595321 ttgcaagaaa cgggaaggaa atcaacgcga tcatgatgcg caaataccat ttgctgtttt 3595381 caagcttttt acggcggttt aaccaaaggc cgcctaacgc agcaagaatc atgacaacac 3595441 ctgctcctac catgatgcgg aagctccaga atgtcgtttt cactggcgga atgtagtcgc 3595501 cttttccgta tattttttcg tactcagcct gaagggtttt catccctttg acacttccgc 3595561 tgaatttctg ataagccaag tagctcaagg cataaggaac tttgatttca tttgagcttt 3595621 tttcattttt tgtatcgatc gtcgcaaaag cggtccaagc agcagggtca ccgctgtctt 3595681 cccataggcc ttcactggca gccattttca tcggctgtga ttccatcaag tgctcagcct 3595741 gcatgtgtcc gctaaggccg acgccaagac cggcacaaag accgacgatc attgcgagtt 3595801 taaaagattg cttaaagaac ggcacttctt ttttcttcag cagtttaaaa gcactcactc 3595861 cggcaataaa gaaagctcca gtggcaagcg caccgaaaat aacgtgcggg aattcaaccc 3595921 aaagctgagg gtttgtaatc aacgcgccaa aatcattcat ttccgcgcgg ccgtttttga 3595981 tcgtaaagcc gaccggctcc tgcataaagg agtttgctgt taaaatccag aaagatgaca 3596041 tgatcgttcc gaatgatacg agccatatgc agagcgcgtg aattttcttc ggcaggcggt 3596101 cccagccaaa aatccataat ccgataaaaa tagattccat gaaaaacgcc aataatgctt 3596161 caatcgcaag cggagcgcca aatacatctc cgacaaaacg ggagtaatct gaccagttca 3596221 gtccaaactg gaattcttgc aaaatccccg ttacaacacc gactgcgaaa tttattaaga 3596281 ataagtgtcc ccaaaacttt gccattttga gatacagctc atttttcttt acaagataaa 3596341 gagtctccat caacgcaacc ataaacacaa gcccgataga catcggcaca aacaagaagt 3596401 gaaacaacgt tgttgatgca aattgtatgc gggctaatac caattcactc atgctttctc 3596461 ctccatttcc ggttaaaact gttaatttgc tcactacttc acaaatagaa ccgagacttt 3596521 gatcagtaat tcacaaaata gacgaaaaaa atattgctca atatttcaca aatgtgtcaa 3596581 aaagtcatcc aatatgatgc aagattgcca gactgaccaa atgacacaat ctctgactgg 3596641 ttcatattaa gtactttaca acgattcatt tcaaaaataa agcctaaaat acctaaaaag 3596701 tcccgcacta tgtgacggat ttttgtctat tttgttgctt atttatgtcg gctgctagga 3596761 taaatgaccc tttattatcg tacatcaaca catcgttcct tgcgaacaaa atgcttgccc 3596821 ccgccccagc actcgagtct cagcattccg tcttaaaccg attttagtca gaatgcctct 3596881 tttcatttga accggtaaga ggagaaaagt tgaatagtaa atttttaata tattaataat 3596941 ttcaattttt tagtatactt aacatagtga acaatttcac tgcatcaaga ataggggagg 3597001 tttttcaatg ggagagcttc aaacacacat gcaattgcaa acggatacaa ttcacgaagg 3597061 ggttcgaaaa gagaattggt ttgcgaaagc catgaatata aaagtaggca tcataccgct 3597121 tcctgtgtat gccttgctgt ttatattaat cactgttttt gttatgcatc acgatgtaaa 3597181 aagtgacatt ttgacatcca ttgccgtcat ggcgtttttc gggtttacct ttgcccaaat 3597241 cggcaaatcg ataccgattg ttcgttctat cggcggcccg gccatcctag ctacttttat 3597301 tccgtccgct gtcgtgtact atcacctgct gcctaatgat atcgtcaaat ccaccacaga 3597361 atttacagaa aactcaaact ttctatattt gtttatcgcc ggtattgtcg tcggaagcat 3597421 tctcggcatg aaaagagaaa cactcgtaaa agcattcatg aaaatcttta ttccgcttat 3597481 tgtcggttct gtcacagccg ctattgtcgg actggctgtc gggacattgc tcggactcgg 3597541 atttcagcat accctgctgt acattgtcat tccgatcatg gctggaggag tcggagaagg 3597601 cgctatcccg ctgtccatcg gatattctga catcatgccc atttctcaag gggaagcgtt 3597661 tgcacttgtt ctgccatcga ttatgctggg cagcttgtgc gcgattattc tagcgggatt 3597721 gctgaaccga atcggaaaga aaaaaccgga atggacaggc aacggcaaag tggaccgctc 3597781 cgaagaagag tcccctgcgc tggaggaatc tcaaagcgga cagcaaatgt tcaacctttc 3597841 tttatttgcg tcaggcggta tccttgctgt ttctttatac ttagtcggca tgctcgctca 3597901 cgattttttc ggttttccgg cacccgttgc catgctgtta ctggctgttc taatcaagct 3597961 gttcagattg gtgcctgcct caattgaaaa tggcgcgttt ggagtgtccc gcttcttttc 3598021 aacagctgtg acctacccgc ttctctttgc gattggggta tccatgacgc cgtgggacaa 3598081 gcttgtcgcc gcttttaacc tcagcaatat tatcacgatt ctgtctgtcg ttgtgaccat 3598141 gatggccgtt ggcttcttca ctggaaaatg gctgaacatg tatccgattg aaaccgccat 3598201 tattaatgca tgccattctg ggcaaggcgg cacgggtgac gttgccattt taagcgccgc 3598261 tgaaaggctt gagctaatgc ctttcgccca ggtgtctacc cgcatcgggg gcgcgattac 3598321 agtatcctta accttattgc tgctgcacca gttttattga tccccgcaag caagttcttc 3598381 gtcaaacgaa agagcttgct tttttgcatg tccatgtttt tgcaagttcc catcccatgc 3598441 tatagtaata gttggaaata ctagatagaa aggaatctgg catgcctatg ggaactcatc 3598501 tatttctctt tatgcttctc gggctgggat tttatttgat atcagcccta gctgcaaaac 3598561 tcattccggc catagacttc tggattgata ttgttctatg ggtcggcgct gcggcttaca 3598621 tcttctctca tctctcattc atggacggca ttgtctcact cgcgacaatg ttctactgct 3598681 attggaccgc aatggatctc attgtttcag agcgtgtgga aaaaccttcg ggagactggc 3598741 aggaaatcga gcttgccaaa aacaaaacac gcctcctgtc agacattacg ctgaccgcca 3598801 ttgtgtttgc aggggctgtc atttttttca tctatggacc tgacacaagc cctctcaaat 3598861 atgtgatcct tctcggaatg atctccggcg gaggggcact tgtgaagcga atactgaatg 3598921 tttttagcgt aaaggttttt tattcagcag ccttagaaaa attgcatatc agctcacact 3598981 atgaaacccg tacatacccg ctttccgatt tgaagaacat tcagcttgaa tcaacagcag 3599041 atctcttaaa gctccatccg cttctgacga tgtattcatc ccgtttagat ttgacaacaa 3599101 gctttcagca agtcattaaa ctgtctcttc ccggcgaaac actgtttctg acggtgaagg 3599161 aaccgcaaaa atggaaaaca attcttcagg aatacacaga tgcagaaaac aatgtggaca 3599221 atgtgatttc tgttttgccg ttttatcatc gaaaaaatgt gaagcggctg ctcggtaagc 3599281 tttattttgc cgccagcgta aaaggggtat ccgcttacgc cttattggtg ctcgcgttat 3599341 acgcattaca cgcctctcca tgggtcatgg ctgttgccgt aatcctatat tgggtattca 3599401 acatgtatat gtcagaccgt gtgttgcggg cggcgatgga cgccaagtct tgtcatcatc 3599461 cgcatgtaca ggccgcggcc gataagattt tcagatcggc cggcatttcc catgtccgca 3599521 tatacgaaac ggagagtgat gattacaacg gaatggcagt aggcatgaat gtcgggaggt 3599581 caatggtcat cctgacaagc gccacactaa cacttccaca gcgtgtcatt gaaggcattc 3599641 tggcccatga ggcgattcat atcaaaaaac gtgacgttct gtcatcacag cttttgcgtt 3599701 ttctatatct tggagctgtc gtggggattt tcctcttgtt tgagcagcat atcacccatc 3599761 ccgaggccca caaaattgcg ctttgggctt tcattatggc aatcattatc ctattccagc 3599821 tctatcaatc cttttgttca caatggatgg aggtgcgtgc tgacaacctt ggcgcatcat 3599881 tgctggacgg cggttacaaa caaatggctg aagccttgag aatcttggcg gttcggcaag 3599941 atgaggatat acagaaacaa agtgcctata gctctgaagc aggtgaagac gagcttcaaa 3600001 ttgattctct cacccgtgat aaaagctggt ttttcagatt gattgatttt cagttcgctc 3600061 ctcatcctcc tatgtattgg cgtgtcggca ctttattgtc aaacaaagga catggggtgc 3600121 taaagcgctg gctcagagac cgactgaaag aatcgatcac tttgaaatga aaccggtcag 3600181 cgtttcatcc gtataacaga tatggtgaaa aaagggagtg acgcgaagtg attgtgatca 3600241 tcttattgtt tatatctatt attgtttttc tttcagtcat tcagccgcag ccctcgaaaa 3600301 acaaaagccg ccagcaggcg gacagcgggt atttcggtta ttcagatcat agctcacacc 3600361 atgatggatg cagcagtgac ggaggtttca gcgattccgg ctgtggcggc ggagggggcg 3600421 gcgattaaac gccgcctttt tttatttcat tgattcgatg tacgcaccaa aagccgagcc 3600481 tgacatgcct ggggacacgc gcacacgatg gagggcatac attccctggt ctctcgaagc 3600541 cgcgcccggt tctgtcgtca cgcccatttg atagcctgtt ttttcagcgg ccttcagcgt 3600601 ctcctcattg tagcgcccta ccggatagct gatgatggtg gtttgctgat gaaacatgtt 3600661 gtcgaacagc tttttcgaat cagccatctc actttgctgc tgttgaggcg ttaatccgtt 3600721 cagctcaagg tggtcaatcg tatggctttc aatcgatatg ccgtgctgtg ccatttcctt 3600781 catttgttcc tctgtcagat ggtgcttatg tccgatcgat ttgccgatca taaaaatcgt 3600841 tgccttcatc ccgtactttt tcagcaccgg atacgcatct tgataattgt cggtgtaccc 3600901 gtcatcaaat gtgatcagca cgcacttctc actcggtttt ttatcctgcg tcagcatgag 3600961 agatgcctct ttcggcgtta atgtctgata gccgttatca tgaagccact tcatatgcgc 3601021 ctcgaattct ttctttggca cacggaggct gtttcctgaa gaaatgctgt ggtacatcaa 3601081 aatcggcagc tttgccggtt tctctgtttt gatccatgcg gatgtatcgt cttctttttt 3601141 ctgaacttgt actgcctttt tttccggttt cttttgttcc gcttttggca tcggctgctc 3601201 tgcattcgcc tcttgatcag cacaagccgc aagagccaaa cagctgccca aaagaaagat 3601261 gcttaaaaac aatcgtttca tcgttctcct gctttctgtc tatttcttcc tcctttttca 3601321 tcggtttgat tctgagattt tcaatagcaa aaaaccggac atgtctccat gtccggtttt 3601381 tttgatctta tcggattctc acttctgtct cactgtcaaa gaaatggcct ttattcatat 3601441 caaatgcaac cgtcagctca tcgcccgatt gaatatcgag gcgggcgtcg atccgcgcaa 3601501 taaagtcttg gttgtctatc tgcgaataaa tcataatttc agaaccgagc agctctgcaa 3601561 cattaatttt cgccttaatc gaagagttct tatatgattc cacgacaatc aattcatcat 3601621 gtatatcctc aggacggatg ccgaagatga cctctttgcc gatgtagcct ttttcacgca 3601681 gcactttcat ttttccttcc gggacggtta atgccgcaga accgattttg attaagccat 3601741 ccgtgagctt tcctttgaaa aaattcatcg ccggtgatcc gataaacccg ccgacaaaga 3601801 cgttttcagg gaattcatat acatccttcg gcgtcccgat ctgctgaatt ttcccatctt 3601861 tcatgactac aatccgtgtc gccattgtca gcgcttctgt ctggtcatgc gtcacataaa 3601921 tcgttgtagt ctgcaatctc tggtggagct taatgatttc cgcccgcatt tgcaccctca 3601981 gcttcgcgtc caggtttgac aaaggctcat ccatcaggaa cacctttgca tcccgcacga 3602041 ttgcccggcc cagcgcaacc cgctgtctct gtccgcctga cagcgctttc ggtttacggt 3602101 gcaaatattc ctcaagcccg agaattttag cggcttcttc gactcttttt ttgatttcag 3602161 gcttcggcat tttccgaagc ttgagcccga acgcgatatt atcgtagacc gtcatatgcg 3602221 gataaagcgc gtagttctga aataccatcg cgatatccct gtcctttggc gctacatcat 3602281 tgacccgttt tccttcaata taaaaatcac ctttcgaaat ttcttcaagt cctgcgacca 3602341 ttcgcagcgt cgttgatttc ccgcagccgg acgggccgac gaatacgata aattccttat 3602401 cggcaatatg aaggttaaag tcatcaaccg ccggttcctt ctgatcataa aatttataaa 3602461 tgtgctccat ccgcaattca gccatctaac atcccccttt gttattgtaa acgctttctt 3602521 atattgagtg taacagcaat tccctctcgc taaaatgggc agcgttcata aaatcaccca 3602581 gccatttttc gtgcatattt ccaatttatt ctgaactttc attttgcagg cagataaaat 3602641 aggcaagaag cgcgcctttg tacgatttga tatctatccc tgaccgctca ataaatttat 3602701 caatccgata ttgcaggctg ttgcgatgca gatgcagctt tttcgctgtt aatgtgacgt 3602761 ttgagttgtt ttcaataaac agcttaatgg tcttccttag ctcagattca cttccaaata 3602821 aaagctcagc ttcttcagag agcagtgttt ccagtttttc tttttctgtt tctaataata 3602881 gaaaaggaaa gatcatctca aaggtcacac tctgcacctg aggcagccgt ttttcagcaa 3602941 acaggaaata cgcctgttca cgagcgtaat gttttcgcag acactcatcc ggctcgtaaa 3603001 atcttccggc gtaaaaacgg acactgaagt agaaatcact ttcaagaacc ttagcgagcg 3603061 attccagttc gtccttctcc gccgccgctt cactttcctg ctcgacaatc acacctctgt 3603121 cctcatggat ccacacaatc acaaaagaca ccggccaaaa atggcgaacc gcttccgtaa 3603181 aggacgtcct ttctattttg ccgaataaat gaaagtgaac aaatctcgtc cgtttcttta 3603241 tatacgccgg caattcccct ctggaaaaaa ggaacgaaaa ccacttgttt tcctcaggtg 3603301 atttcataga cagttgattg ccctcatccg caggcgtcaa aaatgactgc agcaccaata 3603361 cttctttttc actgatctct gttttcggaa tggagatata tctctgattg ctctcatcaa 3603421 aaaaacatag acagccttcc cttatgcaaa gctcctcaga cacaatcgaa ccgggataaa 3603481 tagccagcag cgatttcata gagtctcctc tcttatgtaa ggatctgtat attcagtata 3603541 aggcgaaaca cacatgttct ccactaaaaa agagtatatc cggtatagat agacgagaaa 3603601 ctgaaaggga aacctcattc gtttacatat tggcttcagc ggaaatagaa gaagacatgc 3603661 aggaccaaag gagggtcatc ttatgagttt cgaaacgtta aacaaaagtt ttatcaacgg 3603721 aaaatggact gggggagaaa gcggacgtac ggaggacatt ttgaatccgt atgaccagtc 3603781 tgtgatcaca acagcatctt tggcaacggg caaacagctt gaggatgcgt ttgacattgc 3603841 acagaaagcc caaaaagagt gggccaagag cacgacggaa gaccgaaaag ccgtgctgca 3603901 aaaagcgcgc ggctatttac acgaaaaccg tgatgacatc attatgatga tcgcccgcga 3603961 aactggcgga acgatcatta aatcaacaat cgagctggaa caaacgattg cgattttaga 3604021 tgaagccatg acgtatactg gtgaattagg cggcgtcaaa gaggtgccat ccgacattga 3604081 agggaaaacc aataagattt accgccttcc gctaggtgtc atttcatcga tttctccatt 3604141 taatttccca atgaatctat ccatgagatc cattgcgccc gcaattgcgc tgggtaacag 3604201 cgttgttcac aagcctgata tccaaactgc tatttccggc gggaccatca ttgcgaaagc 3604261 gtttgaacac gccggtcttc ctgccggtgt ccttaacgtc atgctgacgg atgtaaagga 3604321 aatcggggac ggcatgctca ccaatccaat cccgagatta atcagcttta cagggtcaac 3604381 agcagtcggg cgccacatcg gtgaaatcgc cggtcgcgcc ttcaaacgaa tggcacttga 3604441 gctcggcggc aacaatccat ttgccgttct ttcagatgcg gatgtcgatc gtgctgtgga 3604501 tgccgcgatt ttcggaaaat ttattcacca gggacaaatc tgtatgatta tcaacaggat 3604561 catcgttcat caagatgtat acgatgagtt tgtagaaaaa ttcaccgccc gtgtcaaaca 3604621 gcttccgtac ggcgatcaaa ccgatccgaa aaccgttgtc ggcccgctga tcaacgagcg 3604681 ccaaatcgag aaagcgctgg agatcattga gcaggcaaag acagacggca ttgagcttgc 3604741 ggttgaagga aaacgcgtcg gaaacgtgct gacgccgtac gtctttgtcg gtgcggacaa 3604801 caacagcaaa attgcccaaa cggagctgtt tgccccaatc gcaaccatta ttaaagctgg 3604861 cagcgaccag gaagcgattg acatggcaaa tgatactgaa tacggcctca gctctgcggt 3604921 tttcacttct gatttagaaa aaggcgaaaa gttcgccctg caaattgaca gcggcatgac 3604981 ccatgtcaac gaccagtccg tcaatgattc gccgaatatt gcctttggcg gaaacaaagc 3605041 aagcggtgtc ggccgtttcg gcaatccgtg ggtcgtcgag gaatttaccg tgacgaaatg 3605101 gatttcgata cagaagcaat accgcaaata tccgttctaa atgaaaaaat ccctctgttt 3605161 caagtacaga gggatttttc tttatttaga tatatccaca aacccttcgc caaacacatc 3605221 gcgtacgtca tgtacgatca caaacgcttt tttgtcgcag cttctaatga tttttttcag 3605281 catagacagc tcctgtttgt taatgacgat atacaaaatc tcttttgact ggcccgtata 3605341 atttcccttc cctgataaaa tcgtcacgcc ccgatccatc aaggtattta cctgctctgc 3605401 aatctcactc ttattttctg aaatgaccgt aatggctttt ttcgtattca aaccttcaat 3605461 aatgaagtcc atcactttgg taccgatata cagcatcacg atcgtaaaca tcattttttc 3605521 tgcaccaata ataaaataag agctaaatac tacgattaaa tcaaaaaaca agagtgcata 3605581 gctgatattc cagtctaaat atttattagc aattctggcc agaatcgcgg aaccggccgt 3605641 cgtcccgccg acccggataa tcatgccgat cccgactccg gcaaatacac ctgcgaaaat 3605701 cgtattaatg atcaattcat cagacggaat gctccaccca tgtgtcagat gaagaaaaag 3605761 cgaatttgcc gcaaccgcaa tgatcgtata aaccgttgtt tttccatcaa gaaacttgta 3605821 gccgattaaa agcaaaaacg catttaagat aaagttcgtg acaccaggag accattgaaa 3605881 cagataatac aaaatcagcg taatcccagt gactccgcct tccccaagat cattgggaat 3605941 cgcaaataaa ttaaccgcaa gcgcgaagaa aaaagcgcca atcacaagca taagtacatc 3606001 cagcattctc tttttcatca cgaaaacact ccttttcatt gttctgttct agcaaataaa 3606061 aaaacccagg agaacgctct cgaaaaagag cagaaactcc tgggctttta tcccaccgtg 3606121 tcataacagc caagctgcta tgtgttttct ctcggtcaca gtccaatttg cattgcggaa 3606181 ccctagaaaa ccactgtttt tatcatatcc ttttcacttt ccaatattag cattataagg 3606241 gacggttcga attggttcaa ggggtatttg cggagttttc atcagataag ctggaaaaaa 3606301 atacgattta tctattaaaa aagaacagat ataaccgata agaaaaaaag catatatttt 3606361 acaagcgaat gtaactataa atgataataa ttataagaaa ttcataattt tatattgact 3606421 aagagaaata atataggcat tatagtacat atgtttcgta cattttatta cataggagga 3606481 aatataatgg caggaaaact agtaccctgt aaagcttgcg gtcaagaaat tgcaaagggt 3606541 gtaaaaaaat gtcctaactg cggtaaggat caacgtaact tttttatgcg acataaaatc 3606601 attacgttta ttctcgcagt tgttgtcatc attattatcg gtaatatgat tggcggcgga 3606661 ggcggctcag aagccacttc caaaacatca agcagcagca aagcagaaac tgaaaaaaca 3606721 tacaatatcg gtgataccgt aaaaactgaa aaaactgaag tgacggttac gaaggtagag 3606781 gacagagata ctgtcggtac tcaatatgtt gaaaagaaag catctgaggg aggtacaatt 3606841 gtagctgttc aatatacaat taaaaacgta tctaaaaagc cgattagctc tttttcaatt 3606901 ccaactgtta aattagttga tgctgatggt acttcttatg attctgatat tgatgcttct 3606961 gtaaactatg caactgagac aaaagttgat aactctaaaa ttttgagtga tctaaatcct 3607021 aatattaaag taacaggtgt aaaagcattt gaagttgaca aggaagctta tgcaaaaggc 3607081 acttggaaac taaaattcag taatgatgtt attgtgaaaa tcaaataaca gctaacaagg 3607141 gtgcctgttt aggcaccctt gttctttaaa aaaggccttc tcaattgaga aggcctccat 3607201 tcttattccg cactcttata cccattcaca ttagaagact gccatctcca ggaatcagca 3607261 cacatttcct caaggccgcg tttcgcttcc cagcctagtt ctcgcttggc tttcgcagga 3607321 tctgcaaagc atgtggcgat gtctcccgga cggcggtccg caaaacggta tggaacctct 3607381 ttccctgaca ctttttcaaa ggctttgacc atttccagca cgctgtagcc tgtgcctgtt 3607441 ccaaggttgt atgcatcggc tcctgtagag ttcaatactt tttccagcgc cttgacgtgg 3607501 ccttctgcga gatcaacgac gtgaatataa tcgcgtacgc ctgtcccgtc ttttgtcgga 3607561 tagtcatttc cgaatacgct taattgctcg agcttcccga ctgctacctg tgccacatac 3607621 ggcataaggt tatttgggat tccgttcggg tcttcaccga tccgtccgct tggatgcgcg 3607681 ccgaacgggt taaagtaacg aagcagcgca acgctccact cattgtcggc tgtatgcaaa 3607741 tcacgcaata tttgttcaag catgagcttc gtctgcccat aaggatttgt cgcgcctaat 3607801 ggaaagtctt ccgtaatcgg cgatgtttcc ggaacgccgt atactgtcgc agatgaactg 3607861 aatacgattt tcttgacgcc gtatttctcc atggcctcgc ataaaataaa cgttcctgtc 3607921 aaattgttat gataatattt gaggggaatc gccacagatt cgccgactgc ttttaaccct 3607981 gcaaaatgaa tcacagcttc gatttcattt tcagcaaaaa cggaatctac cgcttcccgg 3608041 tccaataaat ccgcttcgta gaacgttaaa tcttttcctg taatctcctt gacacggttc 3608101 agcgcttcag ctgaactgtt ggacagatta tcaagaacaa caatctcgta gccgctgttc 3608161 aatagttcaa cacatgtgtg gctgccaatg taaccggcac cgccagtaac aagtattgcc 3608221 atgatgtaaa ccctcctaaa aaatgacctg ttttcattat atagtgttta gaaccggtcc 3608281 acatccattt ttaagaagtt taatcgttta ttaatagttt tttcatattt tttagcttaa 3608341 acccttgcca gcaattcgat agaggtttca gcaagaatgt gctctttcat ttcttgatag 3608401 agctcattca agtaaaagcc cggctgaaga ttcagctcag catctaaagc atagaccgtc 3608461 aatgtatacg catgatcctt gtcaggcggt gtcggcccgc aatactggtg aatcaccttt 3608521 ggatcgttgc ttcccgcaag cggtgaagca aagctgtttt gcccttgtat catcaagtcc 3608581 tgtctttcct cactcgcatg ttcaggaagc tctccgatgt aagccggaat attagccgct 3608641 gtccagtgaa tccagctgaa tccgcatacg ggaatggcgt catgatcgat gaaagtaagt 3608701 gcgagcgtct ttgctccgga cgggatgtca tcaaaatgaa ttggaaagga tacaaatggg 3608761 tttccttctc tcttatattt ttcatccgcg tattttgaat acttgtcatg taaatatgga 3608821 tttgcttcta cgtatatgtt catatgaatc cctctctcta ttttctcgtt ctataggtat 3608881 actaaacgaa tcgatgtata atcagtgata aacaaatacg catgtaaacg taacaatttg 3608941 ttatggataa cttgcagtga aggagatatt tcatggattt aaaatggctg caaaccttta 3609001 ttgccgcagc ggaatcagag agcttcaggg aggcggctga gcatctgtat ctcacacagc 3609061 ctgccgtttc tcagcatatg aggaaattgg aagatgaact ggacatgagg ttgtttttgc 3609121 atagcggaag acgagtcgta ctgactgacg aaggcaggct ctttttgcct tatgccaaag 3609181 aaatgatcca tgtttaccaa gctggaaagc agaaagtcag tcaatggaaa caggggtaca 3609241 gccgatcact cacgctggcc gtacacccct acattgcgtc ctatatcttg cctcgctttc 3609301 tgccagccta tatccaaaaa catccgcatg tcgagctttc aactcatgtg gctggatctg 3609361 acgctattaa acaagcggtg gaacacaatg aagctgatat tggtttgtcg cggaaagacc 3609421 cgaacaccaa cactctttat tatcagcata tatgcgaagg tacgctttgt ctggcggctc 3609481 ctttccaaga aagcagaccg gatgctgcat ccgtcttaac ccgctatcgg ctgctaacgc 3609541 atgatcatcc gtcatatggg gatgcctttt tagataacat ccgatcacat tacccgtatc 3609601 ttcaaatgat ggctgtcggg cagacggata cggctgtcca catgatgaaa gcgggaatgg 3609661 gggcatcttt cctccctacc tacattatca aacaggaaga agccgaaaaa aagctgatgg 3609721 ctgtcagcac gcctgcacat ctagaattgc ctgcgtccca aacgtttatg atgtggaaaa 3609781 gaaacagcga agacattcag cattttcacg ccatgttaca tgactttatg cagcgcgaac 3609841 aagtatagag ctgaaaaatc aatctgccgg ttgacgtttt tctttcctat tttcgctatg 3609901 cttaatgcag aaaggatttg atgacatggc gatgagccct tatattttta ttgtattgat 3609961 tcttattatt ttatcgatgt atcgagaaag aacggtaaag cccgggaagt tgctgatcat 3610021 tccactgttg ctcttatggg gcgtatctgc atcgtttcag ccggcgtatt ttcattccgt 3610081 attacatgtg gcgatcagcg gcattttatt actgatcggg ctggcctgcg ggtttggcat 3610141 tgggaagatg gtaaatgtac ggattcaccc ggaaaccgga aaggtcactt cacgcggctc 3610201 acttgggagt gttatcctca ttctagtgat actttctttg cgcatggccg cgagaacatg 3610261 gctgcctgag agcaacgaga tgtttattgc cattattcat tctatgttct tcgttcccct 3610321 cggcaccatc acagcccgca acatcatgct ttacaaagca tacagacgac tgaccgctgg 3610381 caaagtatcc attcaataac cgaaagaagg accagcatga acggacaaac tccggctcgg 3610441 cactactaca agaagcttgt gccgagcctt attctcattt tgaattgcat acaattttta 3610501 tctcatccaa ctaaggctga tcccattttg ttagcatttg tatttgcggt atacttagca 3610561 ttcatttgga tcattcccta tgtggcatcc actgctgtta gtttgagcat attcatcgga 3610621 ctctggctcc tgaccgattt cttttgggct gtttccggcc aagagcaggg tgccgcctat 3610681 tttttgattg tatttttaat gatatatgcc gcctttagac tcccttcacg gctatccttg 3610741 atcttcacag catgtttaat tggaggcaac atattactcc tatcctcaca agggggaagc 3610801 ttgaatacca tcatcagcaa catctcgatc atgctcggtc tgtacgtcct cttctcctcc 3610861 atgcgtttca gacgagaagc gagaagggag gctgaacgga atcatgctga attggcaaaa 3610921 atgcatgtgc agctggagca tgctcataaa gaactccaga aagcgcatgc agagctgcag 3610981 gaggcttctg ttctttcatt aaggtacgcg gtccttgagg aacgtacaag aattgcccgc 3611041 gacattcatg acagcatcgg tcacgagctg acttctgtga ttgttcagct tcaatccctt 3611101 ccctatatcc ttaaaagcag caaggaggat tcagaaaaag tcattcaaaa tgtactgagt 3611161 gtcgccaggg agtgtcttca agaagtgcgg tctgttgttc accaaatggg ccgtagtgaa 3611221 tcgatggtgg ggcttaccgc tttgcggggg ctcattcatc aagtggagga acggagcggc 3611281 ttgcacgttt ctttagatac tgccggactg tcagaagagt cttggcctcc aaacgtgagc 3611341 gaaacgatct accgcatctt gcaggaagcg ctgaccaata tcattcgtca cgctgacgct 3611401 tctcatgcgg cggccgtcat ttctaatgac aagtcccatc tctatgtcac aatcaccgac 3611461 gacggacaat tcaccggcag ccttacttat ggatttggcc tgacaggaat gaaagagcgc 3611521 gcagaaaaag caggcggttc ccttactttc agtgccgtac agccgagcgg cctgaaaatt 3611581 gagctgtcat tgccgctcat gacaacgaat aaggagcaaa aagatgaaca aagataaaat 3611641 acgcgtagcg cttgccgatg atcagccgct tgtgcgtgaa ggcttccgct acgtcatcaa 3611701 cgcacagacg gatatgacgg tttctggcga ggccggcgac ggtcacgata ttatagcact 3611761 cgcaaaacaa acaaaacccg atgtcatcct catggatgtc cagatgccgc gttgctcagg 3611821 catcgaagcg gcgaaagaca ttatgtccgc acttccaaat acaaagatag tcattttaac 3611881 cacctttgac acggaagaat acgtatttga aggcatccgt gcgggcgcag tcggctatct 3611941 gctgaaggat acacttcctg aggagttgat agatgcgatt cgcgctgcgg ccagaggcga 3612001 ggcgattttc cgtacagtca cagctgctaa aatcatcagt gagacatttc gggcgaaaca 3612061 gcaaactcat gccgaagaac tggcagagcc gttcaccaaa agagagcttg aggttcttca 3612121 gcaaatggcc tacggactga gaaatgagga tattgctgaa aagcttttcg tcagtgaaag 3612181 cactgtgaaa acccacgtgc accgcatcct gcaaaaatgc aatgcccaag accggacaca 3612241 ggcagtcgtt tttgccattc gaaacggtat tgtgcaatag aaatctctca tcccgccatg 3612301 ctaaaataag acaaaggaga tgattggaaa tgaaagaaga aatcattgaa cggtttacta 3612361 catatgtaaa agtcgataca cagtccgatg aatccgttga cacttgtcct tccacacccg 3612421 gccaattgac attaggaaac atgctagttg atgaattgaa gtccatcggc atgcaggatg 3612481 cagccattga tgaaaacggc tatgtcatgg caactcttcc ctccaatact gaaaaagacg 3612541 tgccgacaat cggctttctc gctcacgtcg acaccgctac agactttacc ggcaaaaatg 3612601 tgaatccgca aatcatcgaa agctatgatg gaaaagacat cgttcttaac gaacagctgc 3612661 aggtcaccct gtcacctgat caattccctg agctgtccgg ctataagggc catacactca 3612721 tcaccacaga cggcaccacc cttctcggcg cagacaataa ggccggtatc gctgaaatca 3612781 tgacagccat ggattacctc atcaaacacc ctgaaatcaa gcacggcaca atcagagtcg 3612841 cctttacgcc tgatgaagaa atcggaagag ggccgcacaa atttgatgtg aaacggttca 3612901 atgcatcctt tgcctacacg gttgacggcg ggccgctcgg cgagcttgaa tatgaaagct 3612961 tcaatgccgc tgccgcaaaa attacgatta aaggcaacaa cgtacatccc ggaacagcta 3613021 aaggaaaaat gatcaactct gcgaaaatcg cgatgaagct gaacagcctg ctgccggcag 3613081 acgaagcgcc tgaatatacg gaaggttatg aaggcttcta ccacctgctg tcgattcaag 3613141 gagacgtaga ggaaacaaag ctccactaca ttatcagaga ctttgacaaa gagaatttcc 3613201 aaaacagaaa agaaacaatg aagcgtgccg ttgaagaact tcaaaacgaa tacgggcaag 3613261 accggattct gctggatatg aacgaccaat actacaacat gagagagaaa attgaacctg 3613321 tcatcgaaat cgtcaacatt gccaagcaag cgatggaaaa cctcggcatc gaaccgaaga 3613381 tttcccccat ccgcggcgga accgacggat cacagctgtc ctacatgggg cttccgacgc 3613441 caaacatctt tacaggcggg gaaaacttcc acggcaaatt tgaatacatc tcagttgaca 3613501 acatggtcaa agccgtaaat gtcatcgttg agattgcaaa gcagtttgaa gcgcaagcat 3613561 aacgccaaaa gccagtccaa aaaaggactg gcttttttgt gtgaaaatga aacattttaa 3613621 acacgtcctc cgtaaaacaa gtatcaacaa atgaggagga aaaacaatga caaaacatgc 3613681 aatcgctgcc aagagtctct tgaaaaaatg gatcatttcc aggccgctta acatgaaaaa 3613741 gaaatccagc ccatttcaaa aaatcagaaa aatgttcaaa cgcttcttca aataaaacat 3613801 caaatcccct aaatacaatc cgtattcacc cgtaccgccc aaatgctccg taatttgggt 3613861 tttttgtgtt caattccgca aaatagggta taaaccaaac aagcaagaaa acagcaccca 3613921 aaaacaggta attcgaatta cgtaaactta ggttaaaagt tatataaagg aatttatttt 3613981 atcgtcgata gtaactatag aaccaatcat caacaagagc aaacagcgta attcaagact 3614041 attttcaggt catcaggtaa tactgtttta gagggacagt ttcttgttat ttattgattt 3614101 agaatttttt gaatactttt tggcatttta tccgtacaat agagagtacc aaaacttttt 3614161 ttgggaggta tgtaatatga tcctatttat tatcatcgca ttatgcggct atcttctttt 3614221 ttctttcagc aaggacaatc gccgcaaacc gcaaaagaca agccctctgc cagcagccgc 3614281 acctcatcac aacaacctaa tcgaccttga cgccatccgc caaaaacgcc ggatgcatct 3614341 ttcctaattc tatatttcaa acgaaaaggc tgctgaatca cgcagccttt taaaattgtt 3614401 ttgatttaga gcctgaaacc ttttcgccac ctatccgtaa tttcatacaa ggcaaaccca 3614461 aaggagactt cagcaatgat cgagttattt atgaaacaaa aaatgttctc atttaaagat 3614521 gcatttcaca tttatgaccg ggatgaacaa gaaacattca aggtggaggg gcgttttttc 3614581 tcgttaggag actcattaca aatgacagac tcatctggga aaacgctcgt ttccatagaa 3614641 caaaaactaa tgtctttatt gccgcgctat gagatttcaa ttggcgggaa aacagtttgt 3614701 gaggtaacga agaaagtaac gttttccaaa ccgaaatttg tgatttccgg gcttaactgg 3614761 gaaatagatg gtgatttatg gagggatgaa ttccaactga cggacgggga aaatgtccgg 3614821 atgtcagtga gcaaaaagtg gctcagttgg ggtgattcct atcacttgca gattgcatac 3614881 gaggaagatg ttctgatttg cactgccatc gctatcgtgc ttgatatggt tttatataac 3614941 gatgaagatg aaagtatttt ctaaaaagca ttgacaattg atccaaaagt aataatatta 3615001 agataattga aatctgaata tgaagttgta ccttatcaag agaggtggag ggactggccc 3615061 tatgataccc ggcaaccgct gtttcaaaca gaatggtgct aaatccttaa gaacattgcg 3615121 ttcttgcaga tgaggcggag atttgatcgt tcaagctctt ccttacacaa aggaagagct 3615181 ttttacatgc ttaatatttc agaaaagagg cgaataacat ggctcaacaa acgaatgttg 3615241 caggacaaaa aacagaaaaa caacgcaaag cacctttccg cgccgatcat gtcggcagct 3615301 tgcttcgttc cgttccggta aaggaagccc ggcaaaaaaa agcggctggt gagatgacag 3615361 cggaacagct tcgtgatatc gaaaatcaag agatcacccg catcgtggaa aaacaaaaag 3615421 aaatcggtct cgatgtggta acagacgggg aattccggcg ttcctggtgg cattatgact 3615481 tcctggaagg gcttgacggt gtggaaccgt tcatcccggc tgaggggatt cagttccata 3615541 acacaaaaac gaaagcgcgc agcatcaaag tgacgggaaa actcgatttt acgagccacc 3615601 cagcgctcgg tgattatcaa tttttacatg agattgccgg taacgcgacg ccaaaattga 3615661 ccattcccag tccaaatatg ctgttttttg gcgaaaaggc ggataaaggg atttatgacg 3615721 atcaagagga atactttcat gatatggccc aagcgtacaa aaaagcaatc aaagccttct 3615781 atgatgctgg ctgccgttat ctccagcttg atgatacgtc atggtctctc ttctttgagg 3615841 acaaaggcag agaggttgtc cgggcgctcg gcggtgatcc agaaacattg ccagccatat 3615901 ttgccaaaac aattaacgat gccgtcgcag accggcctga cgatttaacg atcacaatgc 3615961 acatttgccg cggcaacttc cgctcaacct gggcggcatc aggagggtac gacgctgtag 3616021 cggaaacgat tttggacggc ttaaaccttg acggcctttt cttggaatac gatgatgacc 3616081 gctccggaaa ctttgatccg ctccgttttg tgaagcgcaa ggatctgcaa attgtgctcg 3616141 gcttgatcac atcgaaatac ggcgagcttg aaaatcctga ggatgtgaaa cgccgtatca 3616201 atgaagccgc gcgttttgtc agcttggacc agctatgcct gagcccgcag tgcggtttcg 3616261 cctctacaga agaaggcaac cttctgacag aggagcagca atgggcaaag ctgcgccatg 3616321 tcatcgacat tgccaacgat gtgtggagat aatctatcat tgacagaaat agaaaatgtg 3616381 tgaataatag atactatcag aaaatttaat aaaaaggttt tccttatcaa gagaggtgga 3616441 gggactggcc ctgcgatacc cggcaaccgc tgtttaacag aatggtgcta aatcctttag 3616501 agcaatgatt gctcttgaag ataaggttga gattgtcacg caagctcttc cttatccaaa 3616561 ggaagagctt ttttatattt gaatggaaag aaggaatgga caacatgtca caacaaacaa 3616621 cacccgcaga acaaaaatca cttcaaagaa aaaaaccgcc gtttcgcgcg gatcaagtcg 3616681 gaagcctgct aagatctgag cccgtcaaaa aagcgcggct gcaaaaagcg gccggcgaaa 3616741 tgaccgctga gcagcttcgc caaattgaaa acgacgaaat catccgcatt gtggaaaaac 3616801 agaaggaaac cggcctgaac gtcgtgacag acggtgaatt ccgcagagca tggtggcact 3616861 ttgatttcct ggaaaactta gatggcgttg agccgtttac tcctgagcaa ggcattcaat 3616921 tccataacgt acagacaaaa gcacgcggca ttaaagtcac aggcgatatc gacttttcaa 3616981 ctcacccaat gcttgaagat tactcatttc tccatagcat tgccggtgac gcgacgccaa 3617041 agatgacgat tccaagtccg aatatgctgt ttttccgcgg aaaactggaa aaggatgaat 3617101 acaaaaacga ttatcaactt ttccagcacg atgtatccaa agcatataaa aaagcgattc 3617161 aagcgtttta tgacagaggc tgccgctacc tccagcttga tgatacagcg tgggccgttt 3617221 tcttatcaga aaaaggctta aaacaaatcg aagcgttcgg aacaacgcct gacgagcttc 3617281 gccagctgtt tgcgaaatcc attaacgacg cgattgcaga ccgcccggat gacttgacgg 3617341 taaccatgca tatttgccgc ggcaacttcc agtccacttg gacagcggaa ggcggctatg 3617401 acgcagcagc cgaaaccatt tttgacggct tgaatcttga cggacttttc ttagagtatg 3617461 atgattcacg ctcaggcgga tttgagccgc tccgttacgt aaaacggtct gatcttcagc 3617521 ttgttcttgg cttagtgaca tctaaattcg gtgagcttga aaatccggat gacgtgaaac 3617581 gccgtatcga agaagcgtcc cgttatgtaa gcttagacca gctttgcctc agccctcaat 3617641 gcggattcgc ttcaactgag gaaggcaaca agctgactga agaacagcaa tgggcgaagc 3617701 tccgccatgt ggttgagatc gctaatgatg tttggaaata agcaaagaaa aaaacacact 3617761 tgattcccta gcggagcaag tgtgtttttt atgtcattgt gcggtgtagc ccccatcaag 3617821 gacgacagcc tgcccagtga cgcccttcgc cttctcgctt gccaaaaaca cggcataatc 3617881 cgcaatttcc ttgacggaaa gcagtcgctt ttgcggcaca agcggaaaaa tgacttgttc 3617941 aagtacagag tcgtaaggga catttctagt tttcgataga tcgctaagct gattgcgtac 3618001 aagctgggta tcgacataac ccggacagag cgcattgact gttatgccgt ggggcgcgcc 3618061 ttccagcgcc cctacttttg tgagtccaat gacgccgtgc ttggcgctat tataagcgga 3618121 tttccctgca aagcccacta atccattaac agacgcaata ttaatgattc tgccaaactg 3618181 ctgttttttc atgatcggaa aaacatgctt cattgcaata aagggagccg tcagcatgac 3618241 cttgatcagc tgttcaaagg tgtctgtcgg aaactcttca atcggagcga cgtgctgaat 3618301 accggcattg ttcaccagaa tatccaagcg gccgtattgt ttttggatga cgttcaccgt 3618361 atcagcaact tgcgcttcct ttgtcacatc atacggaatg gccgccgcgt caaagccttc 3618421 ttctgcaagc ttggaggctg ctttttcaca tgcttccgga cggaggtctg aaacgatgac 3618481 gctggcacct tcccgggcga attctcttgc gatttcgaat ccgattccgc cggcagcccc 3618541 tgtcaccaaa gcgacttgtt ttctcatgtc aaacaccttc ccattaagaa ttgagtacag 3618601 actggcttac agcgaaatca gcttctgttt tttcataaac ctcttcaatt gtgacaccat 3618661 cctgaagctc cgtcagtgtc atgcggccgt tcacaaaatc aaatacagcc aaatccgtaa 3618721 tcagcctgtg tacgactttc tggcctgtca gcggaaggga gcatgttttt ttcacctttg 3618781 attcaccatg cttattgacg tgctccatga tgacaacgat tcgtttcgcc ccgttgacga 3618841 gatccatggc gccgcccatc ccttttacca ttttgcccgg gatcatccaa ttggccaaat 3618901 ccccctgctc cgaaacctcc attccgccga gaatagctaa atcgatatgc ccgcctctta 3618961 tcatcgcgaa tgactcagcg ctgtcaaaat aagaggcgcc tgtcacttca gtgatcgttt 3619021 cctttcccgc attgatcaaa tccgcgtctt ccgttccttc cagaggatag gggccaattc 3619081 cgagcaagcc gttttccgac tgaagcatga cgtgaacgcc atcgggtatc tcatttgcga 3619141 caagcgtcgg cattccaatc ccgagattca cattcatgcc gtccttgatt tcttgtacag 3619201 cccgtttgac cattcgtttt ctcgcttcct tcacttggcc tcaccctttc ccgatgcttg 3619261 ctgaactgtt cgtttttcaa tccgtttttc ttggctcgcg ccaagcacga catgctgtac 3619321 gtaaattccc ggcgtatgga tgtgatctgg atcgagctct cctgcttcca cgatttcttc 3619381 cgcctcggca atcgtgatct tgcctgccat ggcggcaatg ggattgaaat ttctcgccgt 3619441 tttcctaaaa atcaaattgc ccatggtgtc cgctttccac gctttgacga tcgccacatc 3619501 gccggtaatg cctcgctcca gcacataagt ccggccgccg aatgttttat gttcttttcc 3619561 ctcggctatg gaggtgccga cgcctgtcgc cgtataaaat cccggtatgc ctgcaccgcc 3619621 tgcacgaatt ctctcagcga gcgttccttg gggaacaagc tctacctcaa gctctccgct 3619681 taaaaactgc cgctcaaaaa ttttattttc accgacatag gaagcgatca ttttcttgat 3619741 ttgcttgtta gccagaagca aaccaagccc ccagtcatcg actccgcagt tattgctgac 3619801 aacggttaaa tcctttactc cctgatctct tatagacaaa atgagctgtt cagggatgcc 3619861 gcacagccca aaccctcccg cgatcagcgt atccccatca tgaatcagtt tcgcagcttc 3619921 cttgcttgat gacagcactt ttcccatatt gatgcccctt tcgttttctt ctacactaga 3619981 ccagtcaggc tgtaaatcgc gatcacagca aatacggcag ccgttttaat gagcgtgatc 3620041 gcaaaaatat cgcgatagga ttgccggtgg gtcaaacccg tcacggccag aagcgtgata 3620101 acggcgccat tatgcggcag tgtatccatc ccgcctgatg ccattgaaat gacccgatgc 3620161 atcacctctg gcggaatatt gtaagcctga atcgcctgta agtattgttc tgacatcgcg 3620221 cttaacgcaa tgcccattcc tcccgaagcc gagccggtga ttcccgccag cgcagttgtc 3620281 gtaacggcgc catttacaag cggatcggta aaagtatgtg aaattccgct gctcagctta 3620341 tgaaaccccg gcagcgcggc gataatgccg ccgaacccgt actcagcacc cgtattcata 3620401 gatgccagca aggcgccgcc aattccttca ttcagccctt ccttcaattg ggcaaacaca 3620461 cttctccaat caaataatat cgttgtgatg atgccaatca ctaaagcaat ctccaccgac 3620521 caaatagcag ccgctgaaga aatatcaagc ctgccgaact cctttaatcc tatggaagaa 3620581 aaatcaaatc cattcggata ccactttggc aggtaaatgg tgaaatattt attcactgca 3620641 ccgacgagaa taagcgggac aaaggcaagc gcgtgccgaa tcgggctttt gtccggttca 3620701 gccgcggact caatcgattc aggagcagga gcattctgcg aatcaaaacc gccatagcct 3620761 tcgccagatg cctgcgcttt cttccgcctt gattccaaat agagcatccc agctgccagc 3620821 acaatcactg cgcccatcaa acccagccaa ggggcggcat aaatgtctgt tttgaaaaac 3620881 gacgtcggga tgacattttg gatttgcggc gttcccggaa gtgcgtccat cgtaaacgta 3620941 aaagctccta aagcaatcgt acccgggatg aggcgttttg gtatgtttgc ttcttggaac 3621001 atgtttttcg caaaaggata tacagcaaat acgacaacaa acaggctgac accgctgtac 3621061 gtcaagacag cacccatcag cacaatggca agtatcgctc tttttgcccc gacaagccgg 3621121 acaattgttt tcgcgattga tgccgcaagc ccggccattt caacgacctt tccaaaaata 3621181 gcaccgagca aaaacactgg gaaatacagc ttaataaaac ccgccatctt ctccataaaa 3621241 attgatgaaa aaaaaggaag cacatggctt ggatctgtca gcagcaccgc gaataacgcg 3621301 caaatcggcg caaacaatat gacagaaaat ccccgatacg ccgtaaacat cagcaaacct 3621361 aacgccaata gaatgatgat cagttccaca cacacatccc ccgtttccgc gaactagaaa 3621421 gcgtttacaa aaacctgtcc gcatcggctg tttccgtccc ctttccatat gtacgagaag 3621481 cgtgggccaa ctattccgat taaaaaagga aagctccttt tttcggagct ttcctctacc 3621541 attcatttca ttcctattag gatatcaaca tcaaccgtaa tatcggctga tttcatctct 3621601 ttcagcaggc tgactcgatc tttcggcgcc gaccaggcaa gcggcgtcat cttgagaagc 3621661 cagtggatcg cctgctggtc aagcgtttta acatagcgca gcctgacagg acggctgtgt 3621721 gctgcatttg ctgtaaaacg ctcaactgct gccgtattgg aatacgtgcg ccttggtgaa 3621781 tcagtatata aaaattgcct taattctatt aaatagtcgc ttcgcggcac tacttttatg 3621841 agcatgccat cattcttcag cagtctatga aactctgcat aattggacgg cgaaaaaata 3621901 gacagaacaa catcaaattg gcgatcatga aaaggagcac gcgccacatc ggcaaccgcc 3621961 cacatcagat ctttgaatgc cttagaagct tttaagatcc cgtccttcga aagatctatg 3622021 ccggttccta tcgctgcttt ccctgcataa tcaaacccgc aaagcgcatt caaatgagaa 3622081 ccctcaccgc aaccgctgtc caagatggtg aatgcctcat gaccagattt gggatgactg 3622141 atgagctctg caatcgcatc atggagcggg tcaaaaaaac cacattctcc aatcagcctg 3622201 ctcctcgctt caaaaagctc ggcaccgtaa ctggttttga ccggcttcgt cagaaagttc 3622261 acgtagccgt gccgagatag atcaaatgta tgtcctcgtt ctgtacaaat caagcttttc 3622321 cctgatgccg catccataga agaatcgcag agcgggcatc gaaacatgct gaaatcaact 3622381 gttcgcttca tgataaaaaa caccccattc attcattttt agataaatga aaaaggcata 3622441 gacaaataaa cctaggccta tctcaaaaat tggccaggtc tggcagtttg tctacacctg 3622501 tcattatcta taacgaatga attggataat catgaaaaaa actccctttc tgctgtatgg 3622561 gtttccccgt ttccatcata caacaaatat ccaggagctg gaaccttata gtgaagaaaa 3622621 atcagtactg acatgctggt atcccgccaa catcatatca gcatagcaat ccagcatgtt 3622681 tttcctttat tttctcattt tagaatataa attttattat tgtgaaaata gttaaaaagg 3622741 ttgattttca aaaagtgaaa ggataaaata ctgctatcat cttagaaaaa gacattcttg 3622801 tatatgatca gtaatatggt ctgattgttt ctacctagta accgtaaaaa actagactac 3622861 aagaaagttt gaataaattt gaacgagttg aaaaggacaa gttcttttct gtttgctctt 3622921 atttttcaca ctttctgcac ttccagaatt tgtgaaggat aagagctttt tttgtttcca 3622981 taataaccct cataggagtt gctatcatgt actttttact aaaccttgtc ggtctcattg 3623041 tgattatggc agttgtattc ctatgttctc cgcagaaaaa gaaaatcaag tggcgcccga 3623101 tcattacgtt aattgttctg gaattgctga ttacttggtt tatgctggga acaaaagtcg 3623161 gaagctgggc catcggtaaa atcggtgatt tcttcacttg gctgattgct tgcgccagtg 3623221 acggtatcgc gtttgccttt ccgtcagtga tggcgaatga aacagtagac tttttcttta 3623281 gtgcgcttct tccaattatc tttatcgtca cattctttga tattttaacg tatttcggca 3623341 ttttgccttg gctgattgat aaaatcggat gggtgatttc aaaggcttcc cgcttgccga 3623401 aattagaaag ctttttctct attcaaatga tgttccttgg aaataccgaa gcacttgcgg 3623461 tcatccgcca gcagcttacg gttttaagca acaaccgcct gctcacattc ggtttaatga 3623521 gcatgagcag catcagcggc tccattatcg gatcttatct ttcaatggtg cctgcgacat 3623581 acgtgtttac agccattcct ttgaactgct taaacgcgct gattatcgca aacctgctga 3623641 atcctgttca cgtgccggag gatgaagata tcatctatac accgcctaaa gaagagaaga 3623701 aagacttttt ctctacgatt tctaacagta tgcttgtcgg catgaacatg gttatcgtta 3623761 ttttggcaat ggtgatcgga tatgtcgcat taacgtcagc agttaatggc attcttggcg 3623821 ttttcgtaca tggcctgacc atccagacaa tttttgctta tctgttcagt ccgttcgcat 3623881 tcctgcttgg actgccagtg cacgatgcga tgtatgttgc tcagctgatg ggcatgaaat 3623941 tagcaacgaa cgagtttgtt gcgatgcttg acttgaaaaa caatctcaaa tcccttccgc 3624001 ctcacaccgt tgcggtggcg acgacattcc tgacgtcctt tgcaaacttc agtactgtcg 3624061 gcatgattta cggcacgtac aattcgatcc ttgacggaga aaagtcaacg gtcatcggga 3624121 gaaacgtgtg gaaactgctc gtcagcggaa ttgcggtatc tttattaagt gctgcgattg 3624181 tcggcctgtt tgtgtggtag aaacattgag ccatatccct tttcggatat ggctcttttc 3624241 attattgata aatagaggct ggcacctgca catcccggat tcccgctgca taaggcccca 3624301 agtcatactg gccgaagacg atggcgatcc cgtttgccgt aaagtaaaac attgtgtctc 3624361 tgtttagggt tatatcctct ttctttacat cagagaaaaa cagcacatcg tgttttttga 3624421 tatagctata taggtaatct ctcgttttgc tgacttttgt tttggtgttc agaatctgat 3624481 ccagcgtcac ccgcttttgt gctttcaagt catagttgaa ggactggaca gacgttagac 3624541 cgtgggcgcc ccctgaatag atataattga gtgtttgaat gctgagcttg cctgccgcat 3624601 tgtatttgac gctgaaggat gtttgatatt cccgttttaa agccctgctg ttcgcctgct 3624661 tttttgtttt tcaggtattc ctgatacgat tgttcatgta ggctttcagc tcttgattga 3624721 ttttcttttc aaacgcggca ttcccgacgt gatgcacttg tggatacgtt aactccttga 3624781 tctttttgta cgtatgggtg ctgacagtcg gtgttttcgc ttgaactgct tttaaagatg 3624841 gggccgcata tgcaaataca gaaaaaagca agactgcaat gcccgcggct ttcagcatgt 3624901 tattccattt catacaatct actcctttga tgtcgttgtt tatcattccc ttatttaagc 3624961 aatacacact tttatagact gattaaatcg aaagaagttt ctaggtctaa cagcatgatt 3625021 tttccaataa aaaaagagac acaggatgtc tcttttttta ctgtttgcgc ccagaaatcg 3625081 cttcatgaag ggcttgtgcc aaatctgtat ttccgaacat ctctaatacc gcaatgacag 3625141 tctggtccgg aatgtgctct gcttcgtgtt ttggcacgac cagatcgtcc atggtttttt 3625201 tcaagctttc attcagcttt tgctgcggat acgctttggc gtacagctcc atcggatcaa 3625261 gatcatggtt cacgcaccac tgggcaaaca ccaaaatcat catattttca tcgcgttcgt 3625321 aagcttcagt gagctgtttt tcgttcattt gtcatgctcc ttatgaaaag tatcttcctt 3625381 aaagatacag gagccgatca aattcgtcta tcccaatggc gatgagcagc aaccgcatcg 3625441 ataaatgcct tgctgaaagc ggtgtagtca ggttcatctt tagccgttac gatgcctagc 3625501 ccctctgttg tcccgacaga ggattgaaga aggtcaattc cttcatttgc cgcaccgatc 3625561 gccttgtagt gattgtaagc ttctctgata aacgccatcg cttgtttgtt gtcttttaac 3625621 tccagtcctc ctgcggcata gacggcatca tacagaacag aatcaaccgt caggaacgtg 3625681 ccgctggcct caagctgctg tccgctgccg cttgtcatat accccagatt ttgactgatg 3625741 atatccactg tgattccttc ttgctttaag gcttccagta ctgtttgcag ctctttttca 3625801 tgaaatccgt ttccggcgag tacagcgact tttcttgttg acgcggtttt cactgtacgg 3625861 gcttggctta acgcaggcga agtaagaatt tctttagatg ctttacgctt cgcgggcgcc 3625921 gccacgccta ctcctttggc gatttcttct gctaaatctg catcgacatt gctgaagaca 3625981 tcaacgacct gccgctgtac gtctttgctt ttgaccttcc cgacctcgaa gcagaaagca 3626041 gaaatgatgt gctgtttctc cacaggagac atgctgttcc agaaaagctt cgcctgtgag 3626101 taataatcgt tgaagctgtc gcttcgctgg cggatttttt tgccctcgac tttttcctga 3626161 tagtggacgt agccgccttc ttcagctgtc gcaggcgacg gatcattgtt ttgcagtgag 3626221 tttttatgat aagcgacagg tcccttattg atcgtcatcc ggtgatagcc gtcgtattgg 3626281 ttgttatgga atggacagac cggccggtta atcggaatct catggaagtt cgggccgcca 3626341 agacggatga gctgtgtatc cgtataagag aaaagccgcc cctgcaatag cgggtcattg 3626401 gtaaaatcga tgcccggcac gacatttccc gggtggaatg cgacttgttc tgtttccgca 3626461 aacacattat cctgattgcg gttcagcgtc atttttccaa tgatcttcac cggcacaagc 3626521 tcttccggcc acagcttagt tgggtcaaga atatcaaaat caaacttgaa ttcatcttcc 3626581 tcatcaatca tctgcacgcc gagctcgtat tcaaccttgc cgccgttttc aattgtttcc 3626641 cacaggtcac ggcggtggaa atctggatct ttcccggcaa ttttttgcgc ttcatcccat 3626701 acgagagaat gcacgccgag caccggcttc cagtgaaatt tcacgaaacg tgcctttcct 3626761 tgttcattga caaaacggaa cgtgtgaacg ccgaagcctt ccatcattct gtagctgcgc 3626821 gggatgcctc tgtcagacat cgtccacatc accatgtggg cagactcagg gttattggcg 3626881 acaaaatccc aaaatgtatc gtgagcagtc gcagcctgag gcatttcatt gtgtggctca 3626941 ggcttaaacg cgtgaaccaa atccggaaat ttgattgcgt cctgaatgaa aaacaccgga 3627001 atgttatttc ccacaaggtc atagtttcct tcttcagtat aaaattttgt cgcaaagcct 3627061 ctggcatccc gcaccgtgtc tgcggagcct ttagaacccg caaccgtaga aaaacggaca 3627121 aataccggtg tcttcaccga agggtcctga agaaatttgg cccgtgtgta ttccgtcatt 3627181 ggttcgtaaa cctgaaaaaa gccatgcacg ccaaatccgc gcgcatgcac aacgcgctcc 3627241 ggaatcctct catggtcaaa gtgcgtcatt ttctcccgga aatgaaaatc ctccatcagc 3627301 gtcgggccgc gaaccccggc ttttaacgag tgctcatcct ctgacactcg caagccttgg 3627361 tttgtcgtca ttttcttccc gctgttatcg gtcctgtact gctcaagctg ctcgtccttt 3627421 gagtgttcat ttacacgttt gttttggtca tcactcatgt ctgctccccc tttttaaaac 3627481 gaaacattct acagcacatt tacccgtggc gttcttcata taaactgcta atccgctcat 3627541 taggattttt ggtctacata taaatatgcg gtcatacaca tttgaaataa gccttcttca 3627601 cagaaagaaa ggatggaagc gcttaccaaa aaagctgttg aataggggag gtcatatcat 3627661 gcttgccata ctcggttttg tgatgatgat tgtctttatg taccttatta tgtctaaccg 3627721 gctttccgct cttattgctt tgattgtcgt tcctattgtg tttgccctga tcagcggatt 3627781 tggcaaagat ctcggcgaga tgatgattca gggcgttaca gacctcgccc ctaccggtat 3627841 catgctgtta ttcgccatcc tgtatttcgg cattatgatt gactcaggcc tgtttgatcc 3627901 tctcattgcc aaaatcttat cgtttgtcaa aggagatccg ttaaaaatcg ccgtaggcac 3627961 agcggttctg accatgacca tttcgctgga cggagatggg acaacaacct atatgattac 3628021 cattgcagcg atgctgcctc tctacaaacg gctcggcatg aaccgtttgg tgttagcggg 3628081 aatagcgatg cttggttcgg gggttatgaa tattatcccg tggggcgggc cgactgcgag 3628141 ggttttggct tccttaaaat tggacacgtc agaggtcttt acaccgctga ttcccgctat 3628201 gatcgccggc attctctggg tgatcgccgt tgcttatatc ctcggaaaga aagagcggaa 3628261 gcggctcggc gtcatttcga ttgatcacgc accgtcttcc gacccggagg ccgcaccgct 3628321 caagcgtccc gctcttcaat ggtttaacct gctgctgact gtcgctctga tggccgcact 3628381 gatcaccagc ctgctgccgc tccctgttct ttttatgact gcgttcgccg ttgccttgat 3628441 ggttaactat ccaaatgtca aagagcagca gaaacgaatc tcggcgcatg cgggtaatgc 3628501 gttaaacgtt gtctcaatgg tgtttgctgc gggcatattc acaggcattc tctccggcac 3628561 aaaaatggtg gatgccatgg cgcattctct cgtttcactc atccctgatg ccatgggccc 3628621 gcacctgccg ttgatcactg cgatcgtcag catgcccttc acctttttca tgtcgaatga 3628681 cgccttttac ttcggtgtcc ttcccatcat cgccgaagcc gcttccgctt acggaataga 3628741 cgccgctgaa atcgggaggg cctccttgct ggggcagcct gtgcatctgc tcagcccgct 3628801 tgtgccttcc acctatctat tggtaggaat ggcaggcgtc agctttggcg accatcaaaa 3628861 attcactatt aaatgggccg tgggaacaac gattgtgatg accattgcgg cgcttttgat 3628921 tgggattatt tctttctaaa tgtatgagct tgatcgtagc attgagtgag tacgtgattt 3628981 acagagggga gaagatcaaa taggatatta tgagtgaata gaagattcat gccaacaact 3629041 tctcattaca atcataagag cctgctatat tgcagcaggc tctttcacat ttggcattat 3629101 ttttttgtat agcgcaccca gtcataatga gcgtatagcg gatttacacc attgtaggag 3629161 ccaagccatt catcgacacc cgtgccattc cacaagttca tcatgatctt tccaggtgtt 3629221 gtcggaattt ggtttgttgc agtatgtttt aattgcccgt cgacatacca tttaatagag 3629281 tttggctgcc aatcgaatgc atacgtatga taggcattgg ctgcatcaaa cccgagatca 3629341 acaatcttct catggtttcc tgcaccattt gtataatagt taaattgaac cttcgttgtg 3629401 tcttttccta aaaattcgat atcaatctca tcccaaggag ttccatctgt tggacctgtg 3629461 taagtgaaga acgatgaaac gatccctgtg tttttagctg gtttcattct gacttcataa 3629521 agtccatagc catatgtttg aacagaacgg ttttccccgc agtcaaactt gttataagct 3629581 gggcttgtta gcgctaaacg catttcaccc aatgacgtca ttgatacgtt attagcccgc 3629641 cacgtgcagt tgaacatatt tccattcgaa taaccatctg ctttttgcca aaaaccggag 3629701 ttatagccgt taaaagggtc aaaaaacgat ccacctgttt gagctgaggc agtagcagtg 3629761 actgcaaaca aactcataaa caatccagtg acaagaagca gcaacactcg tttcagataa 3629821 ggcatattgg cattcccctt tcattgaaag cgttttctat gttgatctta catgattctt 3629881 ttaaaaggga acatcggtca aaataatgat aatatcgaat cttactaact tgaatcctgt 3629941 aactatcatc atcttccctc tgaaaaaaat aaaaacctaa attaccatca gcacagacag 3630001 agatgatccg cactcattgc aatttaggtt ttgcctgctt tatcagtaac aatcctacca 3630061 ttttcatatg tgaatgtaag aaaaagtgaa cacaaggaaa cacaaatgtc agcgctctca 3630121 ttatgcttgt ttaactaccc tttctatgtg aatggttaaa tacagcagct cgtcacttgt 3630181 gagcttgtgc tcatactccc gctcaatgta ggtttggatt ttcttcgtgc attcatacgc 3630241 gcgatgatac ttttctttca ctgtatccag caaaaaatcg tcctggcttt ccatgtgagt 3630301 gccgttaaat agacgctgcg cgaaaaactt taagtgggtg acgaaccgat aatagtgaag 3630361 cgattcttcg ttgaattcaa tcttaaaatg gtattttaca atactcaaaa tctcttgcat 3630421 gacttttgta atgttgataa tattgggcat ctcttcattc agctcggcat ttacaatatg 3630481 cagagcaata aagcctgctt catcctctgg cagagacaca ccagtcttgt tttttaccat 3630541 aaccaacgct tctttgccga tcgcaaattc gtctttgtag agccgttttg tttcccacag 3630601 caaggcgttt ttgatatcaa gccctttctg gttgcgctgg atggcaaagt taatatggtc 3630661 ggtcagcgac acatagatgc tgtcgttgag ctttttgccg agctgtaatt ttgcgtagct 3630721 gataatctct tcggatactt ccatacactc gatcggtata tcatacaaaa gggttttgaa 3630781 cttttctgat acatccttgt tatcgagcgt gaacactttc tcaatgcggg cttcatcgac 3630841 atcatcgccg gactttttct gaaacgcgag ccccctgccc atgacgacca attctttccc 3630901 ctgttcattg accacgctga tcacattatt gttgatcacc ttcgcaattt tcatggcatg 3630961 tccctccaaa tctactaaga acagactata tcttgattgt acattctttt tgtactaggt 3631021 caatatcatc agggaaagac ggaagctggt cagtacaatt cactccgtac ctgctgcccg 3631081 ggctgttttt gaagcagcgc ctccagatgg cgttcaaatg atgccttgtc agctttctgc 3631141 tttttgacaa tgctgttcat gattttaatg ctttcagcac tgtattgtgt atattgtttt 3631201 ttcagctgat ccagctgctg tcttgtcttc ttcgcgtttt tcggtgtgac ttggttgatg 3631261 agtttgatca tactgtctgc ggtctcaaaa aaaccggctc tattttctgt cagctgctga 3631321 atttcgatgc ggctcatatc ttgattacgc gttttttgaa gcaaggcaac cgcctcgctg 3631381 ttttgttttt tgagcgattt gttctcaagc ttaatcgatt cgagattctc cttcgcaatg 3631441 tctgcttctt cttcagtcat gctgattcgc acgaagtatt ctggattgcc gattccataa 3631501 tcaaatgctt cgctcacttg tatcatggaa ctgaacacaa tggccagctg cctgtcgctt 3631561 gcgagggctt ggaaatcctg ctttttctta ctgctcatcg gtttggctgc ggtttgtttt 3631621 actgtctttt gatcacagtc tgcgaacatc tgagcctcac cttcactttc gcatgcgctc 3631681 atcacaagaa ctgtgaccag caggcttata cacaagccta ttcgcctcat gctctgtctc 3631741 ctctctgctg aatcccttct ggaaaatacc ataaaatata gttaaatggt accagatgca 3631801 cctaacccca gcaataaatc aaaagtatga tttgaagcga aaaaacataa atattttgta 3631861 aaaattgacg tgcattccat tcttttcagg cccatttctc gtacaataga agtatcgtta 3631921 ccggagaggg gctctgatga tgaaacgttt tacgaaacaa gaaaacagct gggtgttata 3631981 tgactgggca aattcagctt actcaattgt cgtgaccacc gcggtatttc cgttatttta 3632041 taaatcagca gctgcggaaa gcggtgtcag cgccgctcaa tcgactgcct atctgggcta 3632101 taccattgcg atttcaacgt ttattcttgc gatgctcggc cctattttag gcacaatcgc 3632161 cgactatgaa gggtgcaaga aaaagttctt cggtttcttt gtgtcagccg gtgtcgccag 3632221 caccgcgatg ctcgccttta tccctagtga acattggctg ctattgttgc tgttttatac 3632281 ggtatcggct atcggttttt ccggcgccaa tgtgttttat gatgcctttc tcgtggacgt 3632341 cacgcctgag aagcggatga atctcgtctc ggcacggggt tttggcttag gatacattgg 3632401 aagcacgatt ccatttatca tcagtattgc tgtcatcctg ctcgcacaag cagagactat 3632461 tccagtgtct gtatcggccg caagccagct gtccttcttc ataacggctg cctggtgggg 3632521 gctgttcacc atcccaatga ttaaacatgt ccatcaacgc tattacatca aaaaagaacc 3632581 tcatattgtc atcaacagct ttaagcggct cggccaaacg atgaaacgga tcaggcaata 3632641 ccgggcactt ttcctcttct tgctcgctta tttcttttat atcgacggag tcggcacgat 3632701 tattacgatg tcgacatcct atggatcaga tttagggatc ggctcctcaa gccttctgat 3632761 catcctattt gtcacccagg tagtcgccgc gccgttttcg attatatacg gaaaactggc 3632821 agaacgcttc acggggaaga ccatgctgta cgtcgggatc gtcatttata tgatcgtctg 3632881 cgtgtatgcc tattttatgg agacaacgct tgatttctgg atactggcta tgcttgtcgc 3632941 cacctcgcaa ggcggtattc aagccctaag ccgttcctat ttcgccaagc ttgtgccaaa 3633001 gcgccacgcc aatgaattct ttggcttcta caacattttt ggaaaattcg cctcaattat 3633061 ggggccgctg ctcattgccg ttaccgccca gctgaccggt aaatcctcga ctgcggtgtt 3633121 cagcctgatc attttgtttg tgattggtat tgtgattctt gcctttgttc ccgaggaaac 3633181 cagcacagat gtcagccagc agcaaaatga cctgcccctt taactgggag caggtcattc 3633241 atcatttatt cgctttattc accttcagct gtttcccttt gacggttgtg ttcttcatca 3633301 ctttgagaac atgagggcct ttaccattta aaatctcaac gtatgaggcg ttatccatga 3633361 tcgtgatgat gccgatgtcg tcagctgaca caccgtcaat tttggcaatc gttcctacaa 3633421 aatcaacggc tctgattttc tttttctttc cgccgttaaa atacagcttc ataatgtctt 3633481 tattcagctc ttcgcttttg tcctttttgc tttccggacg gtcattcagt ttagctagaa 3633541 attctggttt cttccttgcc acttcctctt gagaaggtgc ttctattttt tggatttcaa 3633601 atccgatata ttcttcaatg tcggctaaaa accgtttttc gaaggccgtg acaaacgaaa 3633661 tggcctttcc tttgttccct gcgcgtcccg ttcggcccgt gcggtggaca tagctttctt 3633721 tttcaagcgg cagatcatag ttgatgacaa gggagatatt ttcaatatca atcccgcgcg 3633781 cggcgacatc cgtcgccact aagtaacggt actcgccacg tttaaattca ttcatgacgt 3633841 cgaatcggtc ttcctgaatc attccgccgt gaattttatc gcatggatat cccaagtcat 3633901 ccaattcatc ggtcagctga ttgacgtgct ccttcgttcg gcagaaaatg atgcagctgt 3633961 cgggattctc cgtcatcagc acatctttca gcaatgaaaa cttattctct tctcttactt 3634021 gaatcaccgc atgttcaata tttcttgtgg ttaggccggc cgctttgacc tcgatatgct 3634081 cggggttttg catatattga cggctcagct tctcgatatc ctgcggaagc gtcgctgaaa 3634141 acagcatcgt cgtacgctca gtcggcagat gcttgataat cgcctccacc tgctcaatga 3634201 agcccatatt cagcatctca tccgcttcat caatgaccaa ataagagaga cgatccaacg 3634261 gcagcgtgcc tttttcgata tgatccagaa cacgtcccgg cgtgccgaca acaatgtggc 3634321 ttttttgctt aagctcagct ttttgtttat caaaggagga ttttccaaat acggctgtcg 3634381 ctttgatccg tttaaatcgt ccgatgttcg tgatatcttc ctttacttgc accgcaagct 3634441 cacgggtcgg tgttaaaata agcgcctgcg gcttgttttc atcccaattc gccagctcac 3634501 agagaggaat cccgaacgaa gccgttttcc cgcttcctgt ctgtgatttg acgacaagat 3634561 cctttcgttc aagggcagcg gggatcacac tctgctgcac cttggtcggt tctgtatatc 3634621 ccagtccttc caatgctcgt aaaatgtcat gactgatttg atagttttta aaatgactca 3634681 tgtataaact cctgtctctt gcagatgttc tcattatact ctaattgacc aaggcatatg 3634741 tgttttgtcg aaaaatgatg tattaaaagc cagcgattcc ctggcgtttt agctcctgaa 3634801 cagccaatcg cgccagtgcg tcggcccccg cgcgattcgg gtgcagcgta tctccatcca 3634861 tataaagccc gagtgttctt tccggaccga tcgatgtaaa gtatgccgag ctgaggacat 3634921 ttaagtcaat gagatatgtt ttttcctctt cggccaaagc taaaatagag gccctgtacc 3634981 atctgtttac agacgaatgg atgccttcag aagtaaaatc ggttgcccgg ccctgaggcg 3635041 ttgataggat gacgtccgct cctttcgctt ttacctgacg aatcatatca cgcatcacct 3635101 ctttaaactc cgcttcagat tctttatgct tcggatttgt gtcattaatg ccaagctgca 3635161 acataaaata atctccgggt ttaatatact tcagaatcgc ctcaagctgt ccatcatttc 3635221 tgaaccctct cgcgatctgc ccgccagacg ccatgtttct cacttgaaag gtgtgtttat 3635281 cgatatagtg aggcagcatc tgcccccagc ccgcctgctt gctgctgttg agcggataat 3635341 aattgcacac cgtcgagtcg ccgccgacat aaatggttcg attcgttacc ggctgatcag 3635401 acaatttctt tattttcaag gcgctgagcg taaaagcggt gcctgccttt ccctctgtca 3635461 ccagcagatt cagctgcccg tcggtgacgg gaatttggaa cgtatcctcc gcgccatccc 3635521 ctgtcatatt gatgacctga aacacgccct ccgctgccac actggccctt gccgtattgc 3635581 caagcgtcac cttcacctca taaaggccat tcgggagatc aacattaaac gtgttattgc 3635641 ttttcgtccc atacgctaaa aactgaaccg catcactctt cacaccagcc ccggatgccg 3635701 ccacatccct catattctcc ggtgtttgaa aaccgtagcc ctttgaccgg tcataccgat 3635761 cagacgccct gacaccaata taaccaggct ccatcgaacc gcttccaaag tcaaactgat 3635821 acaccttcgg ctccgccgcc ttcacattct caatcccgcc aaaacacagc atcagcatca 3635881 tcacaaaaac cgctgccatc cattttttca tcaagactcc ccctctatga aaacgaatac 3635941 attaatgcat actcggtgat tgtttcttta tgatgactga attaagaaaa aaattgcgtt 3636001 gaggaataaa aatgagggga gagtctcaag aaggggaaaa tcagtgtgac ttcttgtcac 3636061 acttgatcac atcccaacct ccgcaataga agcttatttg gttttcttcg tcatacacat 3636121 aataacggag tctttcccat tgatcgtcag tcggtacaat ctccaatgca accgaatcga 3636181 tggattcaag gtcatccagc tttgatgcac taatgttttc aaaccgcaat tgaatgtcac 3636241 aggtttgagc agatcgtttt cattcaaaca caggaatatg aatataacga tcatcttctt 3636301 tcatatagaa agaaaactcg tttaatgtaa atggacctgt atcctcatca gaaagatgct 3636361 gtttcaattt ctcgtattgt gtgatattca aatgaattcc ctctatttat atgattcacc 3636421 gccaatcata taaatgtcca cagcatcgta ttcaaaccat atgatccgtt cgcctgagtc 3636481 cgttaggcat tggagcttcc cttctgaaaa atagctttta tccggttgag gatcagtgat 3636541 cagaaaaaca tcatcattga tggaagctag cagaaagaga aaatctgcaa tatcccggtc 3636601 tgcttcctgt aatatggatt ggaaatggaa ttcccttttg gccagcttcg tcaccttgta 3636661 agcatgacct tcaaaatact cggacaggtc ttctataaat gaaccagtcg ttattacctg 3636721 tatcatgatt cgatcgtagg caagccctgc ccaaaaacga taaaacgact ctgcatcttc 3636781 aagttcgcat gccataacgg tttggtcagg cttaagctcg atcatgtcca aattgccaat 3636841 actgcttata gaggttattt ccataaaatc ttccccttat cagttggata gcgcaacgca 3636901 aatctcttgt ctgacttgtt catacaagag aatgtgatga tacagatcct tatcgttttt 3636961 gatcatatcc ggaagtatgt caggatacag ctcaaaaaag cttttctcca acgaacgccg 3637021 ctgatgccgg ggtatccttt tattcgccag cacataatcc aaactgccag caacaagcat 3637081 aaaaaactca tagatttccg cttcaaagcc gtacaattca tcagggtact gcttttcttc 3637141 aagctctcgc tgtctttttc tcagtttttg aagcacgttg atcctctccc ttccgcaata 3637201 atctcattta tttcgaaaca gaataggcgg atcattatct atcgcctcca acagctcttc 3637261 accaaacaca gtgattgcac atttccacgg gtctcccaaa agtccccagg agaagtcctg 3637321 atgaaaaaag aaataatagt ctccatttgg aaatacggga acaggccatt cgccaaattc 3637381 atccttaggc attgcctgat gaggactaaa ggtatatccg tcatgctgcc aatctagtgc 3637441 gtacattaca tcgttctttc cagtacctaa ttgaaatgct tttaaaatag aagtctctaa 3637501 atcacttagc actccgctca catcattatg accagcttta ctgctcatcg cgcttgagat 3637561 atcaaacact cgatatggat caggcgggat gatgtgatga catctgcttc cgggcttcca 3637621 ttttatgatc ttgttcactt ctgaccagat gcggtcttgt tttgtctgac ttaaagcgcg 3637681 ccaattcatc ataatctcat ccctacacct tattggatat cctgcttata aacaccagaa 3637741 gaggccactg cgtaaacagc gtaacttgtc agtttcagct gttgaacatc taggccttca 3637801 ccgttcgaat cacagcatgt tatctcttcc atctcttgac tcacatcggc agaaatcaaa 3637861 taaagagacg acttaaggtc tgcactgtaa caattgaacg tcccaaccaa aaaaccttct 3637921 tcggatatcg cgagctgatc aaatgcttct gagtccggct ctttatccga cagaatccac 3637981 acccgtctca cgaccgtttc atcaaatgcg gcaatgactg catctccgta atacagcata 3638041 taaatcaagc cgtttttttc tgcaagtcca taacaatcat ctacagcagg cgcatccatt 3638101 tcttcaagct ttctatcaat gtgtatttcc ttctgctgac catctaacgt aaaacaccac 3638161 acactatggc cgttgggatt ctcatcatga taaatccctt catcacataa accgacccaa 3638221 agctgttgtt tctaatccaa aagacagcag gaaacccctg aaggcaagtg aaaaacactt 3638281 ttcacccttc cctcttctga aaaaaccttt accttcggct cgtacgattc gtaataaacg 3638341 aagacatagc catctgcaca ttgttgaaag agcagaatat cactgtatga aatctgctct 3638401 ttcactctaa aatcccgaac atcaccggaa ggatcataga ttgtaatggt gataccacct 3638461 ttcaaccctt ttccaatgta gacacgcccc tgtggatcag catggaaaaa acaatcttgg 3638521 gtgttctcgt tgatgatttt attcaatttt aattttttca ttggttatgc tcctaggttc 3638581 gaaatgaaat gataagaata aaccatttat tagctattag taacggacaa cctagtttca 3638641 ttaatcgttt tgggataaat ctactttcca attcagcctt aaatcattta gtgtttaatt 3638701 ggtatgcata aaacgattga tcatcaaagc gaactgtttc agcttctata gcaatcagca 3638761 ttctgttcat gtcaataaga aagttagcat ttgattgata ctccggaatt atagaatttg 3638821 atagattccc gattccttct ggatgataac tcatctcaaa tacttgccaa ttgtattctt 3638881 ccggatctat tttttccaat ctcatgtcgc caacatctgc actataataa gcggatgcca 3638941 cattttgaaa tgaaatttta tgcgtatatt caccttcatc ttcaaaaacc ttaatatcaa 3639001 gtgagagttc ttttttaaac acattaaaat ctaaatgaag gacactgcac cccttatcta 3639061 tataatcaac ccattcatta atcgtttgat acattgtcat cccctgcctc tttttaaaca 3639121 ataacgcctt gccaccaagc agaaaacaaa ttactccgta tattgtttga tccaatcatt 3639181 taaatcatct gttgaatgca aataagtttc tgatgaatct ttcaaatcaa tcccacttag 3639241 aaggattaac atatcccaga ctctatcgtc ttctacttcg gggtcatccg cataaacata 3639301 agttccagcc caatccgaca cttcttctct tgttgtttgt ccatttaaga cacttttgat 3639361 tttatttatg cattctatta gatttgtctc gctcaatttg atcaccacgt attcaagtac 3639421 taaatgattt tttattagta tgcaaagcac cgtactgata tttagatatt gaagcttttt 3639481 ccgtaaaaga tatgttccaa aaggtttcca atctaccaat aaacaagctc acatccgtat 3639541 tccgtgtgca atatacataa accaaactgg cacttaggct caaccaaaat aaaactatga 3639601 ttgagaatcc cttcatcgaa ctcaatacac tccaataagc agtcaaggtg ctcgagacat 3639661 tttccaaaag aacaaactaa cgcaccaatt tcgctgctgt attgatgaaa cagcagaacg 3639721 tcccggtcat cgtaagcaac atatgactga gatattttcc agatcagctg tttcgcttcc 3639781 gttttttcga gggcatcaac ctcacgggtg ttggctggta ttgaatttga taaaaccagc 3639841 tcaagcaatt gcctgctttg cgccagatca gcaaaacgat aagtgaagcc tctttctgca 3639901 caagggacta gtttttcttt gatttcgctc atcaataaac gtcttttatt ctcggcgagt 3639961 ttttcgatca atcttttttg catgagccgc attccctccg ctgtcaattt ctcaacttct 3640021 tttaaattga ttcatcattc tcttgttttc gttgtcgttc atgtttagat ttgttctaaa 3640081 aaagcttgta tcgcttatcg atacaagctt tatcttcaac tgcttaaaac tcacccagtg 3640141 ggcttttcac aaaacgctgg gaaccttttt ggcaaatcct cttcatccca atcaattcta 3640201 tatttttaga ttcttttgtc atacaaataa gagaggatgg taacatctct tatttaatgt 3640261 tccatcaata aatgccccat ttttatccaa tgcagaaatt atttataatt aaggaagttt 3640321 agaaggattt tttgtatttt caagatttaa ttttaaagcg gtcacaaaag actctagctt 3640381 ttcttcatta caattaattt cgaacaagtt ggagttcgac ttactttctt tataatcatc 3640441 aaatataatt ttaatcttaa ttctgtaatt tccgttttct tgatcaatac taagaaataa 3640501 gaatggttca atagtctcta aactgatact gtcttgattt ccttttatca tagtttcgat 3640561 cccagatatc aacaccttat attcactttc taataaaaca gcagaaaaat cgcgaacgac 3640621 ggctttctta ttttccaaca attcaaatac agataaaata aatggatcat cgtccaactc 3640681 ttgatacctt ctcggtgtta attcaagttc tatacaatca tcttttattt tggccatatt 3640741 tcctcctcat ttaaagttta agtgagggta gttgtcatcc ccccctcgct taaccttatt 3640801 aacgccttct cttagattta tttccttttc cgtgtgtatg gaatacgtgt ttagaaccct 3640861 tagctcttga acttccataa gctgtgatta ctttacccct tttatttaaa acaactgtag 3640921 ctttttttcc aacatatttc gttgccccat taggttgttt tattactttt ttagggcttc 3640981 gcacagcatt cagtttggcc cttaaattga ctccacggcc tccatttctt cctatagatt 3641041 gattaagtcc atgtcttgta tgacctgtga ttttaactgc cttcttcgta aacttatagg 3641101 cgcgactagc acccttaaat atcttcccag gaccaaaatt agaagcagct gcccaagcag 3641161 cacctttcca tcctttacct gatttatatg ccttatatcc atcataggct gcaaatccgg 3641221 catttaccac aagccatacc caatgcccgt ccggatcaac attcatcact gggttattat 3641281 ttccataagc atacccattc tgatccaatg aatctccgtc gctgcccggg tctgggtcga 3641341 gcgataggaa cacgccgttt cttggctcgt agtagcgggc catgagatag tacaggccgg 3641401 tttcttcgtc gtattggtag cctgcgtagc ggtagcgatt gtcttttact tcgtcgcttg 3641461 cttcggtttt tgttggattt ccccatgcgt cgtattgata cttggcaacg gtttttccag 3641521 tgctgtctga gatcgcgatg atgtcgccgt gagcgttgta gtgatagaaa tatttcttac 3641581 cattttctgt gtaggataac agctggccgc tgtctccgta cgtgtatgat tttgtgacgt 3641641 tgttgtccgc gtctgtttca tacaagacgt tcaagctgtc tccgtcgtag aagtagttcg 3641701 tgacttttcc gttgacggtt ttttggattc tgtttccttt ttcgtcatac ttatatgttg 3641761 cgaatggctt gtcttcgcct tttttggtaa cggcggtcag gttatcttct gcatcccacg 3641821 tatatgtgaa tttgccgtcg gatgtgcggt tgccgttttt atcgtaagag atgctttcat 3641881 cattgacttt tgtcagctgg ttcatgatgt tgaaggaagc gttcaccgtt ttgcttgagc 3641941 cgtcttttat agttgtaacg gttttccggt ttccgaatcc atcatatgtg tattcaataa 3642001 cagtaccgtc ttcatgggtt tctttgacaa gctgattcag cttcccatac tcatattgca 3642061 ccttgccgct tgctgagctg tttatcgttg tgcggttgcc gttggcatca tattcatagc 3642121 tttccgtcag aatgtctccg ccgtttttgt caccgatatg cagcgagctt acaaggtttc 3642181 tttcgtcata tgaaaaactt gttccgccgc cgttgcccgt aataaaggtt tggacgtttc 3642241 cattttcatc ataatcaaat gaatatgagg atgtactgtc tttcatctca atcatttgat 3642301 ccagcttgtt atacgtaaat tgattcgttc ctttttggtc cccatgaatc cacgagaagg 3642361 ttttcagctt atcggagtca ctaggatatg tccaagtttg gctgccgccg cggtctgtca 3642421 gttcggttaa acggtttttg ttgtcaaatg tccgtttctt tgtggtgttc tgctctttat 3642481 tgacgaccga cgtttcattt ccatttttgt catacgtgaa aatgtacttt tctgtaccgt 3642541 tatacgactt tgatttcacc cggtctgttc catcataaga aagagacact tcgttgccat 3642601 ttggtgaaat ggttttggtc aggttgctgt tggcatcata ttcgcttgct aacacattgc 3642661 cgagagggtc agttgttttg acaagcttgc ccatgacatc atattcgaat ttataggttt 3642721 gatctgctcc tgcccggatg gttttgctta cctcattgcc ttccttatca tagctgtgaa 3642781 ggatagacgt gccgttagag agcgtcatgt ttgtcaattg gtctgcctga tcatacgtat 3642841 aggttgtttt ttcacctttt gcatctgttt cagacgtttt cttaccagtt tcatcgtaat 3642901 cagttgaagt ggcgtaacct agttcgtcct cttccttggt cacatagttg ccattactgt 3642961 catacgtgct tttagtcaga aggcttcctt caatcaaacg gatatcatca aaccagactg 3643021 tgcctgtcgc actcttttgg aacagaatac tgatatcgac tttattgatc ggctttgttt 3643081 tagggatgac gacagctgct cggttccatt cctgtgttcc agaagggaat ttcgcattgt 3643141 agatgcctgt gctgccgtca gcgtaagtga cattcgcctg cagagaatag tctttttcat 3643201 ctgtaaattt gacgctgctt gctttcgaca ttcctgtcag tgtgagataa accggtttgt 3643261 catttgcgct ttgccctaag acaacggttt gttttgttac tgatccggct tgggacgcac 3643321 tggtccgggc agcttttaat gatacatcat cattaaagcc ttcttcagaa tcaacggatg 3643381 ctccgcttac attccagttt tccgttgctg atgtgaagct gctgttttga actgggttat 3643441 agcttgatga tacttcgcct ttttccagct ggacttcatc aaaccatgct tttcctttgc 3643501 catctttatc tttatgatcg acttccatat acacaacagc tttgcctgca ttcgctggag 3643561 tcgtaaaagt gatttgccgt tttgtccagt cattttttcc ggctaatgca ctgtattcat 3643621 tgtgaatcca ttgaattcgt ttttgatctt tgtctcgcaa atcaatgtta aaataggctc 3643681 ttgatttcgc aagatctgtt ttgattttcc cgcttaatgt ataggttgta ttcggctcca 3643741 gctcaactgt ttgtgttgct gacgaatacc catgatctgt tccggcagac gttgattggc 3643801 tcaagacctc caatgccttt gatccggaaa gaactccgct tttatcggcg atgactgaaa 3643861 ttttgccgct gtctttagag gcagtcagat tccagccgga tttttgagct tcaaagcttc 3643921 catctttcaa aatattagtt gaagctgata aatctttgct cgattgaatc tggtttccat 3643981 atttatcata aacagctgct gacgatgatt ttccgctctg atcggtttcg gatacagcat 3644041 ccagtccgtc ataagcaata tccgtgacat tgccctcggt atccttcatc tttgtgacat 3644101 cgttgttttt gttgtattcg tatgtctcag ttccatatgc atctttaacc gacgtaacgt 3644161 tgccatcttt gtcatattga tagctttccg ttgcttttcc ggtgccgacg tcatttggat 3644221 ctacatcttc tacaacattg ttgccttcat actttgtatt cgttgtaatt tttaaccctt 3644281 ccgcatcatc aatgacctga atcggatttc ccgcttcatt atagccatac tgtactttcc 3644341 ggccatttgg ctgtgtcatg agaagcgtct ttttatcagc atcatagctg tagacatatg 3644401 tttctttttt agcgttgatc gctttttcga gacggtgacc gctatactga tattcggtaa 3644461 agacaggctt tgcttcggta ctgttagctg aatattgttt gacaaggcgc ccttcactat 3644521 cgtagtcata gcttgtgaca gtcccgtctg tatctgtaac cttcttcagc aaatcattct 3644581 catatgagta ggtgactttc ttattcttag gtcctgtgat ggacgtcaca tggccgtttt 3644641 catcataggt aaatgtaagc ttgcggcctg atgcatctgt aatggcggtc agttgatttt 3644701 tgtcattgta agtatagaca gttgcattgt tatggccatc cactaccttt tggagtttgc 3644761 cgcctttttt attgaaataa gcgttggttt gatcctttgt ttttaatatg aactgatcag 3644821 ctgtttctgt taattcaaga tatacaccgg tcggcggctg atacgtgcca tcggcttttt 3644881 tcgtgaatcg atgtgtcgta gcgtcttcat cgatatacat tgccccgcca tccgttgaga 3644941 tgacagatgt ttctgcatca gcataccagc cttgtccaaa taagtgatca gagctgtcaa 3645001 gactgttgta ggttctcgat aagccaagtc ccggaccgcg tccatcaatt gacaaatctt 3645061 cttcattcac aatgacattg cctgtcgcac catttaactg gccgcttggg atatcaatga 3645121 tagaccagta ctcttctgta cctaggaatt ctgcgccttc atggaacgtt gggttaaagg 3645181 gcgccgttgg aatcgtttca ccattcgcat cataggcgac aagcgtgaaa gaataattct 3645241 tcttcccttt gtaattccca tttgcattgt tatagacagg tgatggatcg agggctaatt 3645301 ccccgccttt tccatctgta tgaagcttat agcttccggc tttgatttcc tcagaagtcg 3645361 gccagatgtt tttattttgg gttgtccaat gatcagcatc accaacatca aaggactgat 3645421 attctttacc gttgtaaatg ttaactttat agcccttcgc attttgaacc ttttcccata 3645481 tcaaattcac ataacccgtt tgactcgatt ttgtatttgt atacaaatag ccagttacat 3645541 tctttggcct agcgatatca ggaagtgccg gggtagcagc cggggatgca atggcttcgc 3645601 cgtctttgtt gtatgcgata attttaaacg agtaatttct tttggctcca tctcccccgg 3645661 cgtttttata ggttggtccg ggattgatcg gcagctctgc tccgcttccg tcctttaggt 3645721 gaagagcata ttttcccgcc ttgatttctg cacttgtcgg ccagatcttt ttcccttttg 3645781 tggtccaaga cgtctgattt ccgagatcaa gtgtctcaaa gcctttccca ttgaacacct 3645841 gaaccttata gccggttgca ccggatacag ctttccaaga aaggtcgaag tatcctgtgg 3645901 cattcccatt attgtagccc tttgctgacg gtgcttgtgc ttttcctaca ttagggataa 3645961 cgggctttgc cggtgcggac atcgctcctt caccttggtc aaatatcgca ctgacgccaa 3646021 tccaatagtt tttgcttgta gcatagcttc cgccggaatt cttatagacc ggggatggat 3646081 ctaatgccaa ttcagctcca tccttgccgt ccagatgcag tttatatctc ttggaggcaa 3646141 tttctgcgct cgtaggccag atttttttac cttttgtgct ccacgacgtg acgttgcctg 3646201 cagaaatcgc ttgatattcc ttaccattgt aaatccatac cttatatcct tttgcgcctt 3646261 caaccttttt ccagctgata tcgaaataac cagtggaatc gccgttgtga taggctttga 3646321 ttgtaggtgt gtttcccttt ggaatggtat acgtcacttc aatatatggt ttattggcgg 3646381 agttcgctga agaaattagt tttttccaat attccttgcc gtttccgttt gtatgaagct 3646441 taaatccata gttggccccg ccggagttcc atgactttac agcagcggtc acatcataac 3646501 tcgcccactg tcctttatgg acgtcggctt ttccgatatt tttagatgcc ggtttggtgt 3646561 tccatgtcac ttttgcatta tcataattgc tgttgaccgt atccagccaa aggccggttg 3646621 cctttgttcc ataataggaa tgggctacgt atgtttttaa tgtagcttta gtgacagtca 3646681 tattttgaat tggctttagg ttgttaaatt tcatgaacgc atagtttgtg cctgttgttt 3646741 tgtcataata gcccgttttc agtacatagg cctttaaatt agcatcccat ttttgtgagg 3646801 aggccgaata gttcgtcgtc gggtaggcac tcatgacaaa cgtatccgat gaaacagata 3646861 aagaagttga cgggtcgata gatactggat atacgcgttc tgggtctttc agccagttct 3646921 cgtctgccgt aagatgaagc aaataccctt cttcattctt ttccagctta tagctgactt 3646981 tgtctgaccg ttcaacctcg ccggaaagct catctagttt tgaatccgtc ataaaaggct 3647041 taggcacaga aaaaacaact tttccttttt catcagaaaa atcaatggat ccatcctctt 3647101 gttctttagc ctgcaaatcg gtttttaact gaaatgtaaa tgtgttgtat ccattatact 3647161 gatgaaggac taaatcttct tttatgtttt cattgaatgt gaaagtctga agatcaatat 3647221 tcggaaacac atccggatac acaatctcat tactgtcagt cttataatct gctgaggtat 3647281 ctttcggagt aagtgaagtt ttattcgggc ctttcgcttc tgctagtgaa tatgtaacct 3647341 tatggtcatt atgctcaaaa gtcgcataaa gcccgttctt catttgcttt tgaaaatctg 3647401 aattcaaaat agcgttctct gtctcgactt gtttgcttgt cgactctttt aactcaggag 3647461 aaatgtcttc ccagtcggca tccggtgttt cctttgtatg aataggatca aggtatactt 3647521 cctgtttata gacaccgtca ccttcataat agagttttgt attttctgtt ctttcagagg 3647581 tgatctcacc ctctttgttt atatcttttg gatcaaaagg tacagcttcc tcagtttgtt 3647641 ctttctgaag agtttcttct ggatcatcgg cagcaatacg gtttccattc tcttcttctg 3647701 tagattttgc tagtacatcg gctggcacta atgaaatcat taaagccaac actaaaaatg 3647761 ctgcaatgaa ccttttaaag tttcgcctct ttcttttttt catttcctct ctccttttgt 3647821 aataaaagta atatttactc aataatctta actagactga aatatcatta caatattttt 3647881 ctagaaaatt tatcttattt taaggattag cgagagtcaa ttgacctaaa acaaaaaaag 3647941 gccgcatagg cctttttaca ttttttattg tatttgttca atatccgtac cctcagctgt 3648001 cacattcgcc ttcccctgcc tcctgacaag cgtcaaggcc atgcccgcaa agatcattac 3648061 gatgccaagc gtttgataga ggtcagggcg gaagcctgtg aagacggtat cgagcacgat 3648121 cgcgacagcg gggtcgagaa atacaatgat tgaaataaat ttcgttgata aaaatcgtaa 3648181 actgtcaaaa aacagcaaat atacaatacc cgtatggatg atgccggtag ataccaccat 3648241 aatccagttt ccctgagata ggtccgcaaa agcgccaaag tgaataaacg gaatcaggat 3648301 gataacccct aaacctgtct gcaagaaggt ggtcgtgtaa ggactgagat tgtgaatgcc 3648361 ttttcccaat aaagtggtga acgcataaaa cagtgcggcg agaactgccc atatgatccc 3648421 tgatcccatc agctgtgtca atgatgtgct gccgttaatc ccggaaatca gcgcagtccc 3648481 aagaaagcag atgataatgg agctgacgga gatcacattt aatttctctc tgtagaagaa 3648541 gctccccaga agaagaacaa gcaccggcgc tagatgataa acagagatgg caattgtaac 3648601 ggacgtttct tcaaaagact taaataagaa cacccagttg aatacaagaa agaaaccgca 3648661 cgccaatgtt tgcagcacgt ctctcttgct ccatttttca gttttatact ggccggacgc 3648721 cagccagcaa aagcctaaaa acagcgtcgc gcaaaggcag cggacaaaga ccaattcaaa 3648781 tgacggcaga ttggtatgct ctgagaaaaa gccgatggag ccgaaaatca ccatagagat 3648841 gaccattttg attacggctg ttgatttttg ttttgacgat atggaaggat cctgttgcat 3648901 caaacgtatt ctacctccaa tactgcatag cataaactgt tttttgtgaa ttcagaaatc 3648961 tacacataga attcctcttt tttacatgta gatattataa cacttctatt ctaaataaaa 3649021 aaaagcgccc aagggcgctt tttttacaaa tctatcgaac aatcaaaacc gggcatgttg 3649081 ataattgaga cactttatgg ctgacgcttc caagcatcat ttctttcagg ccgctgatcc 3649141 cccggctgcc aactacaatc aggctgacgc ctttctcttt tgcgtgattt agtatctcat 3649201 gcgccggctc gccattcgcg taaatggttt cagcttgaac gcctttttcg gctgcttttt 3649261 cttttgcatt ctcaaggatt ttcaggccct cttttttaac ctcgttcctg atttcatcaa 3649321 taaagtgttc aggcacatag acaattcccg tcagagaaga agtcgtgacg acggcttctc 3649381 tccccacatg aagaatgctt agttccgctt gttgctcttt tgccaaatgc actgcggcat 3649441 caagcgcttt tgcactcatg tctgatccgt caatcgctac taacattttg ttaaacatgc 3649501 tcttcccgcc tttcggactg tgggtggttc atctttctct tttattgtcc gcctgcattt 3649561 cgttattgtc aattgaagcg catgagtttt caaaaaattg tcagagactc tctccgtttg 3649621 tggcgataac ctgctgatac cagttgaagc tttttttctt gatgcggtta aatgttccat 3649681 ttccttcatt gtcccggtct acataaatga agccgtagcg ctttttcatt tccgcagtag 3649741 atgcgctgac aaggtcaatt ggcccccatg atgtgtatcc gattaattca acgccgtccg 3649801 caatggcttc gcgcgcttca attaaatgat cacgcagata gttgattctg taatcgtcct 3649861 gaatcgtgcc gtcctcttca accttgtcta cagcgccaag gccgttttca acgatgaaca 3649921 gcggcttctg gtaacggtcg tataaggtgt tgagcgtgat gcgcaagcct ttcggatcaa 3649981 tctgccagcc ccattctgat gatttgaggt aagggttttt gactccgccc agcaggttgc 3650041 cccctgattt tgcaagctct tccggatctg tgctcgccgc catcgacatg tagtagctaa 3650101 atccaatata atccaccgta tgttctttca agagctcttc atcgccttca gccatttcaa 3650161 tttcaatatt gttttctgcc agatagcgtt tcatatatcc cgggtatgcg cctcttgcct 3650221 gaacatctga gaagaaaagt gttttgcgct cattctccat tgccgcgaag acatcctccg 3650281 gcttagaagt catcggatag gttgtcgttg ccgctatcat acagccgatt ttcgaatcag 3650341 gaatgatgtc gtgacccgct ttgacagcaa gagcactggc cacaaattgg tggtgtgccg 3650401 cctggtacat cgcgtttaat ttgttttctc cttcttcaaa aacaagaccg cctccggtaa 3650461 atggcgcatg gagcactacg ttaatttcat taaacgtcat ccaatacttc actttgtgtt 3650521 gatagcgttt gaaaaccgtt ttggcatagc gttcataaaa ctctatgact ttgcgattct 3650581 tccagccgcc ataatttttc actaaaccga gcggcatctc ataatgagag atggttacga 3650641 caggctcaat atgatgcttt aacagctcat caaacagatc atcataaaat ctgaggcctt 3650701 cttcattggg ctcctcttca tcgccattcg gaaaaattct cgtccacgca atcgatgtgc 3650761 ggaacgcctt aaatcccatt tctgcaaata aggcgatatc ctctttataa cgatgataaa 3650821 agtcaatccc gttgtgatac agattcaagg aagtcattga ttcatcaaat ggagacatga 3650881 tcccgttcgg cgatacgtca gctgtcgaaa gccccttacc accctcgtta taagcaccct 3650941 ccacttggtt ggcagcaact gcgccgcccc ataaaaatcc ttctggaaat cgtttttcat 3651001 ttgaactcat attgatcacc ccattagttt tttcaagata aagcaagcag cgcttctttt 3651061 ggctgcactt taccgatctc tttcaccggc gaaaacgaat attggtctgt gttggtcaca 3651121 atcaccgggg taatgacgtc atatcccgcg gctttgattt gctccagatc aaaggacacg 3651181 agcggatctc ccggtgcgac cttgtcgcct tctttgatgt gagccgtgaa ccattgtccc 3651241 tccagcttta ccgtgtccaa tccaatgtgt atgagtattt cagctccctg atcactcgta 3651301 atgccaattg cgtgttttgt tttaaaaatg gtggtaacgc ttccacgaac aggcgaaaca 3651361 acttctcctt cttcaggctc aatggcaaat ccttttccca tgaccccagc agaaaacact 3651421 ccgtctttga cttcacttaa ggctttcact tctcccttaa tcgggctgtg aatgatctct 3651481 ctgctgcctt catgcactgc cggctgctgg ctgccgtcag aaggcacatc ctcgaatcca 3651541 agcaaatacg cagctgctgt tcccgccgca aacgcaatca caaggccgat catcgcgtaa 3651601 ataaacgttg ggccgataaa gacagggatg ctcggcagac ctgcattccc cccgacgata 3651661 taggaagcaa cacccgtcat gccgtaaaac gcgccaccgg ctgcaccgcc aatcaaagcg 3651721 gccgcaaacg gctttttcaa tcgcatattc acgccgtaca tcgcaggttc tgtgatcccc 3651781 atcagcgccg tgatgcttgt ggtaagcgcg agtgatttaa attttttgtt tctagagcga 3651841 aggaagacgg caaatgatgc tcccgcctgc cccatattcg ccaaaaacat agccggcagt 3651901 aaataatcgt ggccgttttg agcgatgttg ttgatcatga tcggcacaaa ggcatagtgc 3651961 atgcccgtca taatgattaa agagaatgta cccgccagca aaatcattgc cacaagccct 3652021 gcatgatcaa acaaataatt gaccccagaa gacaagtatt ctcctaaaat agcgccaagc 3652081 ggaccgactg taatcaatgt cagcggcacg acaatcaata gcgtgaatgt cggaaccaca 3652141 atcaatttga gagatgcgtg tgtaaaacgg tcaatccatt tttccacgta tgaagcaatc 3652201 caaatcgaca gcaaaatcgg gatgaccgtt gacgaataag tggcagcggt tacaggaagc 3652261 ccgataaagg aaatcggttt ccccgcaccg agcagggctg tcaaatccgg atgcaggatc 3652321 gccgccgcaa tggcagccgc tacgtacgga ttgcttccga attttctcgc cgcactcatc 3652381 gctagcagga gcggcaggaa gtagaacgca ccgtcaccga cagccgtcaa aatgacatga 3652441 acctggctct tctccgccat ccagccaaac gtgactgcca gcgccacaag tcctttgatc 3652501 atccccgctc ccgcaatcgc aggcagaata ggggtaaaca ccccagaaat cacatcaaag 3652561 accgcactca gcacattctt tttctgagag gatgaaccag cgctcttttc atcactgaga 3652621 ttgctgtgcc gcacaatcgc ctgatacacc ttcggcacat cgtttccgat aatgatttga 3652681 aactgctcgc cgctgatatt ggtgcccatc actccaggca gctgctccag ctgactgcga 3652741 tccgccttcg cgttgtcatg aagattaaaa cgcagcctcg tcatgcagtg gatcacgcgc 3652801 tgaacgtttt cttcaccgcc tacgagttgt aatatgtcct tcgataattt atcataatcc 3652861 atgtgtatac ctccttttta tggggggact gctggatgaa aggtggccgc ctttcaccag 3652921 ctttttttgt atcaaatgct gcatcacctc ctaaaagaga ataaaaaaac ctaaatgaca 3652981 cagattgcga gagtctcctc ctgcacctgc accatttagg ttttgcctgc tttcgcagta 3653041 acaatcctga cgggtcgttt tatttgtttg taggtatact ttagcactag attcgtgaga 3653101 tgtcaacgct ttcatttttg gtgttgacta tcgtttctag aacaaaagta atcataaaga 3653161 tttgaactta gtattaactt caataaaaaa ttattgtaat taaaaacctt gaaaggcatt 3653221 ttttccaatc aaggttatga atcgttaccg tttaaatttt tttaaagact tctttatctg 3653281 tactattaca ttctttagcc aatctattgg ttctaaatta aacgcaggaa gatacacgcc 3653341 atctgcgcaa gattgaatgt aatcgttttt cttattgtct gaatgctcac tttcaataaa 3653401 atccgttaaa aagacaatag catcctccaa atattcctta ctttcctcta ttaataactc 3653461 ttgtatagcg tcatcaggag tttcaatatc ttgatggaat gttccagcta aaaactgaaa 3653521 aacagggtcc ttctgtttat tgatcaataa catgtcatct tgctccttta agggagaggt 3653581 aacgggataa tgttaaaatc attcatcatc taataaatca agataatact gatcattctc 3653641 ttctattttt cttaagaact cggtaagaga agttgcaatt tgaatatcat aatagtaaat 3653701 cggattttta ttattatcat ttaattcaat tgacattaat gccgattcac taccttcaaa 3653761 aaatattaat ttatcattct caaactcatc atatatttct atgtcaggat aaaattcaaa 3653821 gtcatttatc ctcaatcgaa agtctcttac agaatatgga tccaaaatgc gattagtatt 3653881 aaactctgat cctttaataa acccatagcc aacttctaaa taaaaattca ctaattcact 3653941 aggtaatttt aagtttaaat ttttttcaac ctcttcaatc tcactttgat tcactggata 3654001 aaaatcattt tctttgtttg attttataaa attataactc attttttttt gcctccttta 3654061 aataattcat ttgctggtga gcctgtacca tgaatcccag cttgatgctc gttaggaaat 3654121 tttgctggat gcatattcca ccattcatgt tctccgccaa aagtattttc aattatatgg 3654181 tgagcatcat acttatcccc tttttttcta ataattttac ctgttttttc agatacaaca 3654241 ttttccttat aaacaggcca tttttgtcca gtgttttctt cccattcttt tataacttta 3654301 ttttttactt tatcaaattt agtcctgtgt tttgcagtct ctattggtga cattttttta 3654361 tattctttat ttcttaatgc ttcctttaat ttatctattt gatttttagg taattctcta 3654421 cctgtgcgtt gttctatatc tctagcatac ttttttatta aatcagaatt aattttatta 3654481 gcagatccac ttacatcatt cgcaattttc cctttatcct tagcaacgtt tttaacttcc 3654541 gaagccttct tagccttttt cccattatta ataagtttat taatatctat taacttttct 3654601 aacttagcta ttttggcaaa tggtactgag tttatggagg caacaacacg gtctttccct 3654661 gtgacttttt cgcctgatac cggatctctg cccgtggctg ctttaaatag atcatacacg 3654721 ccggtaagtt ctacagccgt ctctaaaatt ttcacatatc cattctcatc cactttaatg 3654781 tccgaaagcg agacgacagg ttcaagcttc atgtcattac cagatatgta tacattgtaa 3654841 agtgtatcat tataaacgac ttgcttaacc tctgcatttg agaaatcagt ttttatatgt 3654901 tctctatgtt cactcgtatt atacacttta ccattgataa cgatgatatt tttacttacc 3654961 tttttagaat cacccgtttt gacaactgaa tccactttag acttttcatt ctcggctaat 3655021 ttcttcagca tcatctccat cggtgaatca tccgcctgct tcatttgcgg gttaatcgcg 3655081 ccgaagattt ggttgatgtt ttcttcttcc tgtgatttca ggatggagcc gcttttgtag 3655141 cctgtgattt caattttcgg gccggtgtac atggtttcga gctgatcaat gtattttttc 3655201 atcgtttgaa aatctgattt tgcggcttct agtgcttggg tttgctggcc gtcaaattga 3655261 aagagcttat tcagggtgtc tgaaatcagc cgctcagcct gttctgtttc catccgaaaa 3655321 aaggaatcat tgactgtcgg caggctgacg atgtgatcta tggctgatgt ctggcgattg 3655381 actgcgtcag tgagctgctc tgtcacttct cgtgcatgct tgaccccatg tctcgcatcg 3655441 tgtgagagaa aagcctctgc gatcatgccg tgggagttag attctacaga ggaaatcgca 3655501 tgctgtgttt gtttcagcac ttttttgtat tcgtcgataa atatgccaaa gaaaaggaga 3655561 aaaggcttgt ggcactcctc gtaaaaggtc cggatggcat ctccgccttt tcctttcagc 3655621 gcatccttca tgcctgccag atgctcaacg cttttttcca gcttctccag ctgttgtttt 3655681 tgcttgtcca gtttctcaat cgtatgctga atgccctcgt gaagagcgtg gacatctaat 3655741 gttttcaatc ccttgtcctc ccgcgcttta tttcatggaa gatgatatgt tttcgtccgt 3655801 ttccttcatg gcgtttaccg cgctttccgt ttgtgcgata tgcttggcca gaacagacgc 3655861 atatgcttca gtgagctctt tgatgtcctt atttaattgc tcgatggact tcacaacatt 3655921 caaatggttt ctgcctgaga gatgaccggg caatgaggac ttgagttcag ctgaattctt 3655981 gagctgagaa agcccttgct tcactgtgtc atacaccatt ttaatttcct gtgccatttg 3656041 tgctcacctc actttttatg tttttccttc tctatttcat gctctatcct cgtgatttgg 3656101 cgtcttatag aatacacatc gccctctaat gagtggattt ttccttctat gctttcgatg 3656161 attccgctga cttgatcgct tttgatttgc tgatatgctt tgttcattcc ttcacgaata 3656221 tcttcaaacc gctcagcatg tgttcctctc catgcctccc ggttaagatg aggccggtga 3656281 atgagatgct gggcctcaga gaaatcgtgt ttgatttgcc taatttcgtg cagcactcgt 3656341 tttaattgat ggatctgttc ctgcttttca tgtaagtcgg cttttaccga atgtaacaac 3656401 atttcactat gcatgccgca acacctcgtg tttctatcaa actgtgtaaa ttctttacaa 3656461 tacagactat tttcatatta catgatgggt catattggat aaataggtaa aaaggattgt 3656521 cttgagaggt atagaactgg ttctaaattg ctaaaaatac gatctcatca ccctatgaaa 3656581 ggagaaaaca atcatagtag ggacttttta tttaagcctt taatctctcc tccagttcta 3656641 atttttcctc ccacttaact gtttcttata gtcaataaag ctcataaaaa aacaccttcc 3656701 ctcgaaggcg cttctccatc ttatttagat ccccatacag cctcaccgct ggtattcagc 3656761 acactaaacg tcatgacgtt cttctctctc accgaatccc actggcgtaa aaataccccg 3656821 ttatacttct tgcctgctaa cgtgatgtcg gcggtgtttt ttccggtttt cctccatgtt 3656881 ccggtcattt ccccggaaat ggtgtggttt ttgttgagct ggatgttgat ggtttgtttg 3656941 atgtcggctg agatgtcttt tccgtgctgg ataagtttgt atgttcctgt gatgtctttt 3657001 tgttttactt ctttcaatgt ttcgcccgca taacgatatg gtgctgctac cggccagccg 3657061 tctttgttca tgaacaattg gtggactctg acttcgtgtt cttcacccct gcccgggaag 3657121 cgggtgtgga agattaaata ggaacgcccg gttttttcat catagtatgc ggagttgtgg 3657181 cctggtgaga cgtacccggt gcctttttca ttttctgttt caaaagtgta gctgcccatg 3657241 agtttgacgc cgtatggttc gatggaacgg tcgtcgaaga atgtgcctcc cttgccgcgg 3657301 acgtcgagca ttggattgcc ttctgcatca tagtaagggc cgtccggttt cttggagcgg 3657361 gccacacgga tgttgtagcc gcctgttgca tcgagaccgc catatgatag gtataagtag 3657421 tagtattggg tgtctggatt gtagagaaca tacgggcctt cgattctgct gtggttgccg 3657481 ccgagcagtt ttttcccata tccctgtcca ggaagcggga agcccgtttt cggattcatt 3657541 tcaagtatga aaatgccgcc tgagtatgat ccgtacacca tccacagctt gccgtcttta 3657601 tcaaagaagg tatgcgggtc gacgacattc ggatgtttgg ttgcatcata cggtgttcca 3657661 tcgctgcttg tgccttccat tcctgatttc aaaaagatgc ctttgttttt gtatgggcct 3657721 tcgatgttgt cagcaacggc aacacccatg gcggatcttg gcgaatcgcc gcggcaggcg 3657781 ttgtagtaca tgtagtattt gccgtccgcc agctgcgtga cgtcagccgc ccaaagagta 3657841 tcggattgcg cccattcgaa ggtttctttt aattcttcat agacattcgg gataagtggg 3657901 ttgtcattgc ttacgctggt ggtcagctgc tgccattgca tgaggtcatt cgatttagct 3657961 gaagcgagat gagatccaaa aacataaaaa gtgccgtttg tttcaatgat ggaagggtca 3658021 tggacgctga cttctttaaa tataggtttt tgtgcataga cggagtttgg gagggtgaag 3658081 gccatgataa gagctgcaag aaaacataca cggaacaatc ggttgaacat ctaaacaatt 3658141 cgcctctctt ttttattaaa ttttaaacgc ttacatttct ctatgaagat accccggcct 3658201 attaaaacag ccgaatgttt tcatattcat ccagataggt gatttctcac ttcacttaca 3658261 tagtcagact gatgtctgtc tgttttgcgc agaacttgtt gcttgcatat cctctccttc 3658321 atagttcaac tcttttgctg tttctccttc ttgcatcacg tctgtttttc tttcgcgtac 3658381 atgtaataac tgctttgtca ggttttgcat caactgtgat acagccattt cgttgtcggc 3658441 gttttttaag atgatgcctg attgcccgtc aacaccagag tcattcggct ggctctttat 3658501 aaaacgcctt gcgaaaaata cgacttagta aacgcatatt gagagttaga cagcggcgct 3658561 tgcctccttg tctggatatc gtgtgcaatc gctgaaaaaa cctgttctgc tttctgcgtc 3658621 acgctattac aatagcaatc taacttgtta aagactataa aaaaaccttt tgacttctgc 3658681 tgctgaacca attaatataa tactcagtta atagttatca gaatttttag gaattgagtg 3658741 attcatatga cactgcataa agagcgtcgg atcggccggc tgtctgttct cctgctgctg 3658801 aatgaggcgg aagaaagtac gcaggttgag gagctggagc gagacggatg gaaggtctgt 3658861 cttggcaagg taggatcaat ggacgcacat aaagtagtag ccgcaattga aaccgcttcc 3658921 aaaaagagcg gtgtcattca atctgagggt tatcgggagt cacatgcgct ttatcatgcg 3658981 acgatggagg ctttgcatgg cgtgaccaga ggtgaaatgc tgctgggatc gctgcttcgg 3659041 acggtgggat tgaggtttgc cgttttgagg ggaaatcctt atgaaagtga agcggaaggc 3659101 gattggatcg ctgtctcgct ttacggaaca atcggggcgc cgattaaagg tcttgagcat 3659161 gaaacattcg gcgttggaat taatcacata tgaaacagcc catagatctt agacgatagg 3659221 gggctatgcg tgaaaacaga agttcacagc atagctcctt tttgtatggg cgctttacca 3659281 aagtaaagaa aaaggagttg ggcttatggt gactttagac ggttcttcat tgacaacagc 3659341 cgacgtcgct cgtgtgctgt ttgattttga ggaggcagcg gcttctgagg aaagtatgga 3659401 gcgcgtgaaa aaaagcagag cagcagtgga acggattgta cgcgacgaaa agacaatcta 3659461 cggcatcaac accggatttg gcaaattcag cgatgtcctg attcagaaag aagactcggc 3659521 ggcgctgcag ctgaatttaa tcctttctca tgcctgcgga gtcggcgacc cttttcctga 3659581 gtgtgtttcc agggcaatgc tgcttttgcg cgccaatgcg ctgttaaaag gcttttccgg 3659641 tgtacgcgct gagctgatcg agcagttgct tgctttttta aataaacgcg tccatcctgt 3659701 catccctcag caaggatcac ttggcgcaag cggagatctg gcgccgcttt cccacttggc 3659761 gcttgcgctg atcggacaag gagaagtctt ttttgagggg gaaagaatgc cggcaatgac 3659821 aggcttgaaa aaagcaggta ttcaaccggt aacgctgaca tccaaggaag ggcttgcctt 3659881 gattaacggg actcaggcca tgactgcaat gggggtggtc gcctacatcg aagctgagaa 3659941 actagcctat caaacagaac gaattgccag cttaacgatt gaggggttgc agggaattat 3660001 cgatgcattt gacgaggata ttcacttagc ccgcggctat caggagcaga tcgatgtcgc 3660061 agaacgaatt cgcttttatc tatctgacag cggcctgaca acctcccagg gagaactgcg 3660121 ggtacaggat gcctattcat tgcgctgtat tccgcaagta cacggtgcga cttggcagac 3660181 actaggatat gtcaaagaaa aattagagat tgaaatgaac gcagctacag acaatccact 3660241 cattttcaat gacggtgaca aagtgatttc cggcggaaac tttcacggac agccaatcgc 3660301 ctttgccatg gattttctga aaatcgcaat atcagagctt gcgaatatcg cagagcgtag 3660361 gatcgaacga cttgtgaatc cgcagctgaa tgacctgccg ccgttcctga gccctcatcc 3660421 cggtctgcaa tccggtgcaa tgatcatgca gtacgccgcg gcctcactcg tttctgaaaa 3660481 taaaacactg gcccatcctg caagtgtgga ttccattccg tcatccgcca accaagagga 3660541 ccatgtcagc atgggaacca tcgccgctcg gcatgcttat caggtgatcg caaatacaag 3660601 gagagtcatt gcgatcgaag ccatttgcgc attgcaggct gttgaataca gaggcataga 3660661 acatgcagcg tcctatacga aacagctttt tcaagaaatg agaaaagtcg tgccgtccat 3660721 tcagcaggac cgtgtttttt cctatgacat tgaacgcttg actgactggc tgaagaaaga 3660781 atctttaata cctgatcatc agaataaaga actaaggggg atgaacatat gactgatgta 3660841 aaaaaatcaa tccgtgccaa cagaggaaca gagcttgaat gcttaggatg ggagcaagag 3660901 gcagtgcttc ggatgcttcg aaacaacctt gatccagaag tcgccgagaa gccggaggac 3660961 ctcatcgtat atggcgggat tggcaaagcc gcacgggatt gggacgcttt tcacgccatt 3661021 gagcattcct tgaaaacatt aaaaaatgat gaaacattgc tcgtgcaatc cggaaagccc 3661081 gttggcatgt tccgtacaca cccgcaggcc cctcgcgtgc tcctagcaaa ttctgttctt 3661141 gttccgaagt gggcagactg ggagcatttc cacgaacttg agaaaaaagg gttaatgatg 3661201 tacggacaga tgacggctgg cagctggatt tacattggct cacaaggcat attgcaagga 3661261 acctatgaaa ccttcgctga gctggcgcga cagcacttcg ggggcagctt aaaaggaacg 3661321 ttgacgctga cagcgggtct cggcggaatg ggaggcgccc agccgctgtc agtcacgatg 3661381 aatgaaggcg tcgtgattgc cgtcgaggtt gacgagaaac gcatcgacaa gcggatcgaa 3661441 acaaaatact gcgatcgaaa aacagcatcg attgaggaag ccttagcttg ggctgaagag 3661501 gcaaagctgg caggaaaacc tttgtccatt gcacttctcg gaaacgcagc tgaggtgcat 3661561 cacacacttt tgaaccgagg cgtcaaaatt gatattgtga cagatcagac atctgcccat 3661621 gaccctttaa tcggttatgt tcccgagggc tattcccttg atgaagctga ccgtttgcgt 3661681 caagacactc cagagcttta cgtgcgcctt gcgaagcaaa gcatgaaaaa acatgtcgaa 3661741 gccatgctgg cctttcagca aaagggctct attgtatttg actacggcaa caatatccgg 3661801 caagtcgcaa aggatgaagg gctggagaat gccttcgatt ttccggggtt tgtccctgcc 3661861 tacatccgcc ccttattctg tgaaggaaaa gggccgttcc gctgggcggc gctttccgga 3661921 gatccggcag atatttaccg tacggatgcg ttattaaaag agctgttccc gacaaataaa 3661981 gcccttcacc gctggattga tatggcacag gaaaaagtca ccttccaagg cttgccgtcc 3662041 cgtatctgct ggcttggata tggagaacga aaaaagatgg gcctcgccat taacgagctg 3662101 gttagaaccg gggagctaaa agcgcctgtc gttattggga gagatcattt ggactgcggg 3662161 tctgtcgcct ctccaaaccg ggaaacagaa gcgatgaagg atggaagtga cgctgtcggt 3662221 gattgggctg tgctaaatgc gcttgtcaac acggcggcgg gtgcaagctg ggtttccttc 3662281 caccatggcg gcggcgtcgg aatgggctat tcccttcatg ccggcatggt tgcagtggcc 3662341 gatggaagtg agctggctga cgagcggctc gcgcgggtct taacgagcga cccaggaatg 3662401 ggcattatcc gtcatgcgga tgcgggttat gaacgtgccg ttgaagtagc gaaggaacag 3662461 gacattatcg tgccgatgca aaaataaagg agtgatgaca tgccaaagca aattgatacg 3662521 attctcatca acatcggtca gcttttgacg atggaaagca gcggtccgcg ggcaggcaaa 3662581 agcatgcagg atcttcatgt gatcgaagac gctgttgtcg gcatccatga acagaaaatt 3662641 gtgttcgccg gacaaaaagg ggctgaagcc ggttacgagg cagacgaaat cattgactgt 3662701 tcgggacgcc ttgtaacgcc tggcctcgtt gatccgcaca cccatcttgt atttggcgga 3662761 tctcgtgaaa aggagatgaa ccttaagctt cagggcattt catatttgga tattctggcg 3662821 cagggcggcg ggattctgtc tacagtcaag gataccaggg cggcttcaga agaagagctg 3662881 ctgcaaaaag cccattttca tctgcaaaga atgctgtcct acggcacaac cacagcagaa 3662941 gtgaaaagcg gctacggctt ggaaaaagag acagagctca aacagttgcg tgtcgcaaag 3663001 aaactgcatg aaagccagcc tgttgacctt gtttccacat ttatgggagc ccatgcgatt 3663061 cctcccgaat atcaaaacga tccagatgat tttctggatc aaatgctttc ccttttgccg 3663121 gaaatcaaag agcaggagct cgccagcttt gctgatattt ttacagaaac aggcgttttt 3663181 acagtcagcc aatcccgccg ttatttacaa aaagcagctg aggcaggctt cggattaaaa 3663241 atacacgcag atgaaatcga tccgcttgga ggtgctgaat tagcaggtaa gctaaaggcc 3663301 gtctcagccg accatttggt aggtacatcg gacgaaggca taaagaaatt ggctgaggca 3663361 ggaacgatcg ccgtcctctt gccgggcacg acattttatc ttggcaaaag cacatacgcc 3663421 agggcaagag ctatgattga tgaaggtgta tgtgtcagct tggcaacgga ttttaatcct 3663481 ggcagctcgc cgactgaaaa tatccagctg attatgtcca ttgccgcgct tcatctgaaa 3663541 atgactgcag aagaaatatg gcacgcggtc acagtcaatg ccgcatatgc cataggaaaa 3663601 ggagaagaag ccggtcagct caaagctggc cgctcagctg atcttgtcat ttggcaagcc 3663661 ccgaactata tgtatattcc gtatcactac ggggtcaatc atgtacatca agtcatgaaa 3663721 aatggaacaa ttgttgtcaa cagggaggga gccattcttg gataagtacc cttttctcag 3663781 agaggccgga tcttcgttta aagaccggga tgtcacaaaa atgagcgacc tgatcgcaac 3663841 atgggacggc caggacatta agggaccggc gttgataggt gtccccctat caaaatcctc 3663901 catcagtcat tcaggcgctt cctttgcacc cggaacaata cgccaggctc tgaaacattc 3663961 atcagcctat tctgctgagc ttggagagca cgtcgtatca gagcttctat atgacctggg 3664021 ggatatcgat attcatgtca ctgatatcgt aaagtcacat catcacattt tccaaaccat 3664081 gcacgctctg ctttcggatc atccggattg ggtgccgctc atacttgggg gagataactc 3664141 tatcagctac tccacaataa aagcgatagc acaaacaaaa ggaacgacag cggtgattca 3664201 atttgatgcc catcacgatg ttcgcaatac ggaggacggg gggccgacaa acggcacccc 3664261 cttccgccgc cttttggatg aagagatcat tgaaggtcaa catttgatcc agctgggtat 3664321 cagagaattc agcaacagcc aggcctatga agcatatgca aaaaaacata acgtgaacat 3664381 tcacacgatg gacatgatcc gggaaaaagg actaatccca acgataaaag agattttgcc 3664441 tgttgttcaa gataaaacag atttcatttt tatatctgtt gacatggatg tcttagacca 3664501 gtcccatgca cccggctgtc cagcgattgg cccgggcggc ctctatacag acgaattgct 3664561 tgaagcagtc aagtacatcg cacaacagcc caatgttgcc gggattgaaa ttgttgaagt 3664621 cgaccctacc ctcgattttc gagatatgac aagcagagct gcagctcatg ttctgttaca 3664681 cgcattaaaa ggaatgaaac tctccccatt caagtgatct tctggcaggt tgtattttgg 3664741 gtataagaaa ctcatctgcc taaggaatgg cagctaaaag gagggcgaga cagtgaatct 3664801 tcaggagaac agcagccaac agctaaaacg cacaatgaaa agcaggcacc tatttatgat 3664861 ctcattggga ggcgtcatag gcacaggact tttcctcagt acgggctata cgctacatca 3664921 agccggaccc ggcggtacga tactcgctta tgtaatcggc gggttgatga tgtacctcgt 3664981 catgcaatgt ctcggcgaat tgtcggttgc catgccggtg accggctctt ttcaaaaata 3665041 tgctacaaca tttatcggtc catctaccgg ttttatggtc ggcatcatgt actggatcaa 3665101 ttgggtggtg acggtaggct ctgagtttac cgcatccggt attctcatgc agcgctggtt 3665161 ccctgacagc agtgtatgga tgtggagtgc gatttttgca gcccttcttt ttatatgcaa 3665221 cgcattttca gttaagttat ttgcggaaac tgaattttgg ttttccagcg taaagattgt 3665281 caccattatt ttatttatca ttttaggagg agccgccatg tttggcctga tctctttaaa 3665341 cggaacggcg gatgctccta tgttgtcaaa cttcacagat catggcgggt tgtttccaaa 3665401 tggctttctc gccgttttta tcgcgatgat atctgtgagc ttcgcctttt ccggtacaga 3665461 gttaatcggc gttacagcag gagaatcagc aaatcctcaa aaggatatac cgcgatccat 3665521 ccgtaatgtc gcatggagaa ccgtgatttt tttcattggc gctgtcttca tattatccgg 3665581 gttgatttca tggaaggacg caggcgtgat tgaaagcccg tttgtcgccg tatttgcgga 3665641 gatcggaatt ccttacgctg ctgatattat gaatttcgta atattaacag ccttgctgtc 3665701 tgtcgccaac tcaggcttat atgcttcgac ccgtatgatg tggtctttag caaatgaaaa 3665761 catgatcagc tcccgtttta agaaagtgac atctaaaggc attcctttaa atgccttaat 3665821 gatcagtatg gctgtatctt gtttatctct cgtttccagt atcgtggccc ctggaactgt 3665881 ctatgtggtg atggtcgcaa ttgctggatt tgcaggagtc gtggtctgga tgagcattgc 3665941 cttgtcccaa ctcttgtttc gaaagagatt tttgaaaaaa gggggggatg taaaagatct 3666001 gacatttcgc acgccgcttt atcctcttat gcctatagcc gctctcttat tatgttctgc 3666061 ttcttgtatc ggtcttgctt ttgatcccaa tcaaagaatc gcacttttct gcggagttcc 3666121 ttgtatcatc ctttgctatc tcatctacca tttcaaaaga aatgttacaa aagcgaaaaa 3666181 aatcagccaa gaggaatatc cagccgatca catcctataa ttaaaaaagc acaccccgct 3666241 cagcatggga tgtgctttat tttttattct gtaattaacg tatgaatcag cttcggcgcc 3666301 ttcgcttccg cggcgatgcg gatgttgtca tagacttttg cgatgacttc atcgacgttt 3666361 tctcggttag cgtaaagcgt tacgagcggt tccccttttt ctactttgtc gccgaccttt 3666421 ttgcggagca tgatgccgac ggctaaatcg atttcgtctt cttttgtggc gcggccggca 3666481 cctaacagca tcgccgcgac gccgatttcg tccgcgacga tttcagagac gacacccgct 3666541 tctttggcag gcacatcaat ttgatatgcg gcttgcggaa gcttagacgg atcgtcaaca 3666601 attgagctgt cgccgccttg gtttttcagg aaatccttga atttctcaag tgctttgccg 3666661 tttttcatga cttcttccag cttcgctctc gcttcgtcca atgtatcggc ttttttcgca 3666721 agcacaacca tctggctgcc gagcgttaag acaagctcat gaagatcctc aggcccctcg 3666781 cctttgagcg tgtcgatcgc ttctttgact tcaagcgcat ttccgatcgc aaagccgagt 3666841 ggctgggaca tgtctgaaat gacagccatt gtttgacggc cgacgttatt tccgatgcgt 3666901 accatcgctt tggcaagttc agctgcgtct tcttctgttt tcatgaaggc gcccgctccc 3666961 gtttttacgt caagcacgat ggcgtccgcc ccggcagcga tttttttgct cataatcgag 3667021 cttgcaatga gcggaatgga attgaccgtt cccgttacat cacgaagcgc gtacagtttt 3667081 ttatcagccg gcgttaaatt gccgctttgg ccgatgaccg caaccttgtc gcggttcaca 3667141 agtttaataa attcatcctt cgtcagttcc acgtggaagc ccatgattgc ctctaactta 3667201 tcaatcgtgc cgcccgtatg gccgaggccg cggccggaca tcttagcaac cggcacatca 3667261 agagccgcaa caagcggagc gagaacgagc gttgtcgtgt cgccgacgcc gccggtagag 3667321 tgtttatcca ctttaattcc ttcaatggca gaaagatcaa tcgtttcacc ggagttcacc 3667381 atagccatcg tcaagtccgc gcgttcacgg tcactcatat cctggaagaa aatcgccata 3667441 gcaagcgcgc ttgcctgata atcaggaatg cttccatctg tatagccgtt cacaaaaaat 3667501 tgaatttctt cagtggtgag ttcttttccg ttttgttttt tgatgatgat atctaccatt 3667561 ctcatgtttg gtcaccgatc cttttcgatt aagttcagta aatcaagccc acaattgctg 3667621 ctgataaaaa gctgacaagc gtagcaccgt ataataattt caagccgaaa cgagcgacga 3667681 catttccttg cttttcattc agtcctttta cggcaccggc aatgattccg attgaggaga 3667741 agttcgcaaa tgacacaagg aataccgata cgatcgctgt tgtacggccg ctgaaatgga 3667801 aaccgttttg cgtaagcgac gtcatggcga caaattcatt cgataccatt tttgttgcca 3667861 taatgcttcc cgcattaaca gcttcattcc atgggatacc gacaagaaaa gcgaatggag 3667921 caaacacata tccaagaatg ccttggaacg aaataccgaa tactgcatta aaaatgccat 3667981 tgatcaatgc aataatcgcg acaaatccaa tcagcatcgc agcgacgaca accgctactt 3668041 tgaaaccgtc aagaatgtat tctccgagca cttcgaagaa ggattgtttt tcttcttcct 3668101 caacacgaag catatcctct tcttttgcaa cctcgtacgg attgataata gaagcgataa 3668161 tgaaaccgcc aaataagttc aaaacaagcg ctgttacaac atattccggt ttcagcattg 3668221 tcatatacgc accgacaatc gacattgata cagttgacat cgcagatgcg caaagcgtgt 3668281 acaagcgctg ctgatttaaa agaccgagtt ctttcttcaa ggagataaat acttctgact 3668341 gccctaaaat cgcagaagcc actgcgttat acgattccaa tcttcccata ccgtttacct 3668401 tgctgagggc aaggccgata tatctaatga taaacgggag gactttccac ttttgcagaa 3668461 tcccgatcag agcggaaata aacacgattg gcaagagaac attcataaag aatgtcgttt 3668521 ggtccgcatt caccaagccg ccaaacacaa agttaattcc ctctgccgcg tattcaagca 3668581 ggtaaccgaa tccttttgca aatcctccca cgaggaaatt ccctattccg gtattgagga 3668641 gaatgtagcc aagaataaat tgcaaaatga gcataacaac aattgggcgg atcttaattc 3668701 tttttttgcc gctgctcgcg atccacgcga ggcctaaaaa cacgattaaa ccgataatcc 3668761 caatcaaata cttcatatgt gtttctcctt tatttgtatt cgcttacaat tactgtttcc 3668821 tcagaaaacg gaaagcagtc tgccttccgt cagctcttaa tagttgtctc cgcctgatgc 3668881 attttctcct tttacgatag aaacgcctgc gctggcgcca attcggcttg ctccggcctc 3668941 taccattgtg tctacatctt ctttcgttct gacgccgcca gatgctttca cgccgatatc 3669001 aggccctact gttttgcgca ttaaggcgat atcttccttc gttgcgccgc ctgtagaaaa 3669061 gcctgttgat gtttttacga aatccgctcc cgcagacacc gctaaacggc atgcacgttc 3669121 tttttcttca tcagtcagaa ggcacgtttc gataatgact ttgacaagcg cttttccggc 3669181 tacagcttcc actacaccgc ggatatcagc ttccaccaca tcgtcttcct tgtcttttaa 3669241 agcggcaata ttaatgacca tatccacttc agtggcgcct tttgaaatgg cgtcttttgt 3669301 ttcgaacgct tttgtttcag ttgtattggc accgagcggg aagccgatga ccgtacaaac 3669361 gtcgactcca gttcccttaa gctcttttgc agcaagctcc acccatgtcg gattgacaca 3669421 tactgaagca aatttgtatg ttttcgcttc ttcaattagt tttagaatgt ccgctttttg 3669481 tgtatgcggt ttcaaagctg tatgatcaat tatgttggct aatgacatcc ttcgcacact 3669541 tccttttttg ttaagatatt ttttagcata accgactttt gaacatatgt aaattggtaa 3669601 ttgaaatttt gttcaatgaa aggtttgaac gtgtcacaaa tcattaacaa gcgccctcgc 3669661 ggtatgctgg tcaatgatta aaacgttggc atattttccg gttaatgctc cgtgaatgga 3669721 agatactttt ctgcttccgc cggcaactaa aatggagcgt tccttcagtc taaggtcttg 3669781 aagctcaaca ccgatggtcc ggtcattgat ggcgctgctg caaatattcc ctttcgcatc 3669841 aaaaaagcgt gaacaaatat ccccgacggc ctgttttttc agcagggctt tctcttcttc 3669901 gttaaaatat ccgagccgaa acaacagcgc ttcatcacgg acagtcccga ccgtaaagag 3669961 agcgatattc gcctgcttgc ccatctcaat gatccgttca atatgacggt ctttctccac 3670021 cattcgcttc acatccgcat tatcaaacac gacgggaagc gggagatagc gcggcatcgt 3670081 ttgaaaagcc tctgcaaaca gctgaatcgt ttcagccgaa tacgtgttta cccgggaatg 3670141 gctgatgccg cctttcagct ggacgacctc gacgcctttt acctgcttcg gctgcatgtt 3670201 ttgcgcgatt tgatacatgg tggttcccca gctgacgccg acaatgtcgc cgtcttttac 3670261 cgtttcatgc atatattctg caccatagcg gcttaggtca tgtgtaattc ctgcataatc 3670321 gggtgtcggg gaaaacacaa catgcgcctc aaggagcccg tatttctctt caagtatgga 3670381 accgagcgca tccaaatcct caaaagggtc catgacgcga atctggacat accctttttc 3670441 ctttgcatat tgcagcagcc gggaaacggt tggccttgaa atgttgagct gctcagcaat 3670501 ttgctgctga ctgtagtcag actgatagta aagccttgcc gcttctatgc ttaattgctg 3670561 tttttcccga tccattctgc acctccctgt ggatcagtcc tgataaaact gcttttgatt 3670621 tgcttttatt atacaggctg gcgccggctt tcatccacct gatttctaag aaactgaaaa 3670681 acgctctggg cgcggacctg cccagagctt acttctccca agtcatatgc tgataaatgc 3670741 ctttcataat ggcgtacatt ccatatagga tcaggcctaa tgccaatata gacagaatca 3670801 atttgccatg cggctgctgc gcgagttctg cgagcgcgcc gtcaaagcct cttgtgtcgt 3670861 cgggatcagc ggtcatggct gtcttgatga gaaaatagcc gatagccgag aaaataatgg 3670921 cccgggcgat attgcctgcg cgtcctgtgt ttttcgtgat gcatatcatc tgtttgttca 3670981 tttttgatgt atcgaattct ttcataaaag cagcccgaac gcctttcata aattgaacaa 3671041 tcgcaaatac gataaaaccc gcacccgtaa gccctgtgag ccattggccg aacggctgcg 3671101 ccaatacata agcggaccac gtctgttctg aagtgccgcc gtccccttgg ccaaacacaa 3671161 atcgcaaggc attccaagcg atggatgtgt aaacagcggc actgaaaaag tttcctattc 3671221 tccgcgacag gcctcgcctg ctgtttccgt gcccctccgt gtccttgatc gcgcttaaca 3671281 ccatccagat cacatagccg ataaggccga tgcctataaa aaaaagcaat agtgacccat 3671341 acggcatgcg tgatagcgtt tggagagctc cgctcgaatc tttggcgcgg cctgccccgg 3671401 cagccgtcat aaaagccaaa accccaagca gaataaaaac gccgccgaat gcaaaataac 3671461 caagcctccc gaatcgtttg atccaaggct tggtttcctg ttttattttt gacatgtacc 3671521 ggtctttcac cgccatgtgt ccaaccctct ttcacagaaa tctttactgt aacattcccg 3671581 attgaacaaa gttgaaacag ctcctgcctc agctatggct ggctgagata cgtttttgct 3671641 gtttagctga ttgtgcaggt gtcatccaag cagccgctgc ggcagctgtg actccgcctg 3671701 ctaatttccc aatgatcatg gccgccgcca tttctttttt cattccagct acaaaaccga 3671761 gatggctgcc gagtacaaag gcgccgctga ccgcaaacgc gacattgatg acctttcctc 3671821 tcggcgtcat atcctttaat gaagccagca ttgggatatg atgcgccaaa gaggtcacta 3671881 agcctgctgt tgctgtctca tctaaatgaa ggcatttccc cagagcctga agcggttttt 3671941 taaaggtttt tgtaataaat gccgtcatcg ggaacgcccc tgccagagca atggcgatgg 3672001 tccctgtcgt ttgtatccct gtctcgacat tctccattcc cggaatcagc acaatgccgg 3672061 tcatcgtttc aacagaaaca gctgcaagcc cgataatcgc aaccatactg accgctttcc 3672121 cgaagagatg aaacaactga atcattctgt cggtgtatcg ccataaccca aaagcgatga 3672181 cagcagataa cagactcggg atcagaagat ttttacctat catgccgatg tcaaagcctg 3672241 cgcataatcc gccgattaag caaccgatcg gcactgtgca cagcccgatt aatatgcctt 3672301 tcgcaaaata cggatgatcc tctttttcga tgatgccaag agcgacggga atcgtgaaga 3672361 cgattgccgg ccccatcatt gttcctaaaa acacccatga aaacagcccg gcctgcggat 3672421 ctttcgccat ttctccagcc agcgcatatc ctcccatatc aatcgccaaa atggtgttcg 3672481 caaaggaaga aggatccgcg ccaatcgctg tgtaaaacgg agcaacaatg ggaatcaaga 3672541 ttgctgccag cacgggcgcc agcgatacaa ttccgatcat ggacagcgcc agcggcccca 3672601 tagccttaaa gccgtccgca aaccgctcgc ctagccccca tctgtttccc aaacaataat 3672661 ccgctgctcc ccatagtaaa aaggcagcca aaatgaatac aaccgcgtca ttcaccgtca 3672721 tggttttctc ctttttcaaa cgtatgattg gttttatcat atcatctgaa atcaccgaat 3672781 agagttgatc ttattcaata tgagctaaaa attcttttat atcggctttt tcaacggctg 3672841 ttataatgcg tcgcgctttt tcttgcggga ccgttaatgt caatttttct attatgtctt 3672901 cttcagacag ctcatttcct ggtgcccctt ttgggcagtc cacacgcgct tcgcaaatcc 3672961 ggccgtctga taaataggcc cggacaatcg tgaaacggcc ttttggaacg gcatgaggag 3673021 ccggctgaat agcattgtca tatacgcgct gaattcgccc cattgtcgtt tgaaccccgt 3673081 ttgggatcgg ctggctgctg aaatgttcaa cggtcaggcc gtgtccatgc aaagcaagag 3673141 caatcacata ttcaacgctg aaacggcctt cctctccagc ttttggagat ctttccgtca 3673201 atgcagcatc tccgcctggc ggaaatatca cttcaatacg ttcggtattg gcagcagaaa 3673261 tggtttcttc ggagataagc tgtcgtaccg catctgcagc atggtgtgcc gcggaacaaa 3673321 atggatagat tttaaaccat agacccggct gcacaattct ccacggtgcc ccccaatcgt 3673381 ttagcaaagt gtgttgtgct ttctcaacgt caccgtacag actgaagaaa ccagtttctc 3673441 catcaagtgc cgtgcgggac ccgccaaatt ctgattgggc cagcttaacg gccagcaagc 3673501 cagcctgagc cgccaaaccg gcgtgcagcg gtttcatttc tgttccaaat tgcaccctca 3673561 tcccagcaga ttgcgtagcc gcaaaaccaa ttgctttttc caactcttcc tgagtcagct 3673621 cctcagcata acctacggcg caggcagcag cgatggcacc aagcgtacct gtattatgcc 3673681 agcccttctc atagtggcgg ctgccaattg attctcccag ccgtgccatc acttcaacac 3673741 caacaacata agcgccaaga agccgctcgt catgtccgcg agcggcagaa gcaataaggg 3673801 ccggtacgat gactgcactg gggtgtcctc ttacatcgga gtggacatca tcaaaatcca 3673861 atgcatgggc gataaatcca ttgagcatcg cggattgtaa tggcgcggcc tttttgccct 3673921 gtccgataac aggaacaagg ggccggcctc cttcatcctc tatcagacgg aggagctttt 3673981 gaattccttt atcttctctt cctgcgaatg aagcggcagt aaaatcaagt aatccctttt 3674041 ttgcttcgtg aatcgcgtca actgaatgct caggttgtga cgttctcaca gcctctgcaa 3674101 gacctgctgt cagcccttgt ttgctcattt gatggtctcc aatacaataa ccgccagctc 3674161 cgcaaagtat tgagaggcaa ccgtaagggc ttcttcatcc agtgtaaagg ccggatgatg 3674221 ccactcctcc gtcccgttcg ttcccatcca gacaaaaaat cccggaatct tctcttgata 3674281 cagagcgaag tcttctccgc ccggagactg ctcagcgtga acggtttgat agccaagccg 3674341 tgccgcagct tcggatgccg cattcaaaaa tgtgccgtca ttctgaacgg aaggcaaata 3674401 aggaaaccac ttgaattctg cttgtgcccc atagcccgct gcaattcctt cagccactcg 3674461 tctcatatgc tcgggaacag cctgcctcgc ttctttttga aaggttcgaa ccgtcccctc 3674521 catttcagct tggtctggaa ttacgttcca cgaggtgccc gcctgtactc ttgtgatact 3674581 gacgactgcg ttttgcagtg agctgatatt gcggctgacc acagattgca gcccgctgat 3674641 gatttgtccg gctgcagcga ttggatcaat actgttattt gggatgccgg cgtgcccgcc 3674701 tttccctttg atgacgatct caaatcggtc aacacttgcc atgagcggac cttcctttac 3674761 accaatggtc ccgacaggca gatccggctt attgtgcatg ccgaaaatcg cagaaacgcc 3674821 attaagtacg ccagcttcta gaacctttct tgctcctgcg gcaatttctt cggccggctg 3674881 aaagataaag cggactgtac ctttcagctc ggcccttctt tgattcagca acatcgctgt 3674941 gccaataata gaagcagtat gaaaatcgtg tccgcacgca tgcattgtgc catcaacctt 3675001 agatgcaaat ggaagattcg tctgttcttg gatcgggagc gcgtcaatgt ccgctcgtat 3675061 tgctatcacg gggccgtctt cccgtccttt gatttctgca atcacaccag tcttcaattg 3675121 agggacatca agtatttcga tttgctcctc ctcaagccaa cggcggattt ttttcgtcgt 3675181 ttcaacctct tgaaatgaca gttcaggatg ttcatgaaga tcacgccgca tattgattaa 3675241 acgggtatga aacgctttgt cggccattgt tcttctcccc ttcttatata agctctgcag 3675301 gctctcccac ctgcttgata aatcgtttcg tccgttcgtt tttcggatgg tcaaacagtt 3675361 cctctggcgt tccctgctcg ataatatggc cgtctgccat aaaaatcact tgatcagcaa 3675421 cctcttttgc aaacgccatt tcgtgtgtaa caatgatcat cgttgtttgt ttttccgcaa 3675481 tggacttgat gacctgaagc acccctgtga cgagctcagg gtcaagcgct gacgttggtt 3675541 catccagcaa aatcgcatgc ggattgaccg caagcgcccg cgcaatgccg attcgctgct 3675601 gctggccgcc ggacattgtg attggatagc tgtcagcctt atgctccaga ccgacttgtt 3675661 tcagaatctc cattccaata cgtttcgctt cgtcgcgtgg tttatgttga gccacgatta 3675721 aagcttctgt aatgttttgc agagccgttt tatttttaaa cagattgtag ttttgaaaga 3675781 ccatggccgt ttgctggcga agccgatgtg cttccttgcg tgtaaacttt tccgcattca 3675841 gtttggcttc tccgatttca ataaggcctt gatccggacg ctctaataga tttaagcacc 3675901 ggagaagcgt tgattttccg gaaccggacg gaccgatgat tgccaccact tctccgcgtt 3675961 tcacttctag atcgattccg tcgagcacga cgagatcttt aaacgctttg cgaatatttt 3676021 ttactgttat caactgattt cacctctaag tccggtatgg cttgctcatg gcacgttcaa 3676081 acaagtcctg caaaatgctg tagataatgg taagaaccca atagacgatc gcaaccgcca 3676141 aatacgtctc aaaatatttg aggtttcctg aagcgtacat cttcccttgg gcgaacatct 3676201 ccatgacccc taatgtaaag gccagtgacg tttctttcag gagcccgata aatgtattgc 3676261 ccgttgccgg aatcgcattt cggatcgctt gcggcaaaat aatccgtctg tatgcctgaa 3676321 attttgtcat accgacagac aggcacgcct ccagctgccc gtcatcaaca gaattgaggg 3676381 cggcccggaa gatttctgcc aaataagctg cgttttttaa gcttaacccg atgatggcag 3676441 ctgtgagagc tgtcattttg ctcatctctg gaaatagctg cggcagcccg taatagatta 3676501 agaacagctg tacaagtgtc ggcacgcctc ggaaaaagga tatatacagc tttgacagct 3676561 gatgaagcac tggaattttg ttttttgtaa tgagtgcgag aataagtcct ccgataatgg 3676621 caaaaatcat agctgctatt gccataaaca aggtgatcgg aagggcctga attaaagtcg 3676681 ggaacgctga tatcatgaat tcccaatcaa tcgtgttcat tctggtgagt caccgccgtt 3676741 tcttaatgct tctgttctac tgtgatatct tcattaaagt atttttcaga gagttttttc 3676801 agtgttccgt ctttacgcaa ttcatctagg gccttattga cttttttgcg gagcttgtcg 3676861 tgcgcatcgt ccttggcaaa tgggaatgca acctgttcgt aaacaatcgg atctcctgca 3676921 agctttaatg gcaaaccggt cttcttgatt tgcgcgatca atacagttcg gctgttgaca 3676981 taagcgtcta cacggccgta cgcaacatcc ttcagcgtac cctcttgtgt ttcgtacgtt 3677041 ttgatattga tttttttatc aggatctttg ctttcaaggt ttttcgcgtg gtttgaaccg 3677101 agaacggctg cgactgtctt gccttttaaa tcgtctactg atttgatgtc tgtattgtct 3677161 tttttgacga caatctgtgt tcccgcataa gcgtatggtt tcgtaaagtt atacgtttcc 3677221 ttacgttcgt ctgtcacagc tacctggttg gaaatggtgt caagcttgcc tgtttgaagc 3677281 tctcccatca gcccgctgaa ttcaagcagc ttccagtcca gtttcatgtc aattttctta 3677341 gcgactgctt ccatcacttc cacgtcaaag cctgtcagct ttccgttttc tttataagca 3677401 aatgggtaac tttgtcctgt cgcaccgaca tgaagcacat tgtcatcctc tttactgctg 3677461 ctgtttccat tgccgcaagc tgagagcacc gctaataatg cagcaacgac cagcactgtc 3677521 cattttttca tcttcatttg attttcccgc cttttctatt tttatagatc atgtcgcaat 3677581 tgttttttca tatagactgt gatatgccct tttccaaggt cttgttcacc tgagcggaca 3677641 tatccttttc gttcgtacat ctcaatcagc cacggatgct tatccgctgt tccgagtgag 3677701 acaaacggaa cctttaacgt atcgcgaagg attgtttcct ccagccattg aagcagcttt 3677761 gttccgattc cttttttacc ggtgtcgggg tccacagcaa accaccagat atgcggaacg 3677821 ccatacggtc ccggctgttt tccccaaggc attctcaagg tgatggtcgc gatgatccgc 3677881 ccgtcttctt ccatgacgta gcaagcattt tcccgaatat ttttcagcac caaatccaaa 3677941 tccgcatgag cagcagcaaa acgaatgccg agctttcgaa tcggttcata agcccgcaat 3678001 gtcagctcga gaagctgttc ggcatcacgt tcaactgcaa ggcggtatcg tggcttcatc 3678061 tagcgttcct ccttactttg catagcggtt taccggcttt tccaaaccga agtgctctcg 3678121 taatgttgtg ccttcatatt cttttctgaa cacgccgcgc tcctgtaaaa tcggaaccac 3678181 ttgatcaaca aacacttcaa ttccttctgg aagaagcgga ggcatgatgt taaacccgtc 3678241 acacgctttc gtatccaccc attcctgcat cttgtcggcg agctgctccg gcgtgccgac 3678301 gaagatatgg tggcctctgg agcctgcaac gtatttgtaa agctctcgta tcgtcatatt 3678361 gtcacgttca gccatctcct gaacaagctt gaagcggctc ttcaccgcat tggaagcttc 3678421 ggcgtcaagc ttcggcagcg gcccatcaag cggatatgcc gacaaatcaa ttccgcctaa 3678481 gtaattttgg agaatttgca gaccgacaga tgggataatc agatcttgga gctccttgta 3678541 tttggcttgc gctgcttctt ctgtatcggc aatgattggg aaaatacccg gcataatggc 3678601 aattttttct ggatcacgtc cgaattccgc agcctgttct ttaatggatt gataaaattc 3678661 ttgagctgat tccaggtggt tttgtgctgt gaagatcact tcggctgttt tggcagccag 3678721 cgcttttccg tctcctgatg atcctgcctg gataatgacc ggctggccct gcggggttct 3678781 tgaaacgttt agaggtccgc gaaccgagaa atattctcct ttgtggttca gctcatgcat 3678841 tttttctttg tcaaagaatt cacccgtttc tttattacgg ataaaggcgt cctcttccca 3678901 tgaatcccaa agccccttta caatctcgac aaattcctct gcccgctgat agcgcaaatg 3678961 gtgttcaagg tgcttttcac cgctgaaatt cagcgctgtt gattcaatag atgaagtgac 3679021 gacgttccat ccggcacggc cattggacag atgatccaat gacgcaaact gtctggcaat 3679081 atggaatggc tcgctgtatg tagtggaggc tgttgctgtc agtccgattt ttgatgtgac 3679141 ctgcgccaaa gcagagagca gggtgaatgg ctcaaacctt gttaatacat ttggatgtga 3679201 tttgctgtca attgaaaggc tgtccgctaa aaacagcata tccagcttgc ctcgctccgc 3679261 tgttttcgca agctctttaa aataatccaa attcatgctc gcatctgacg gcgcgtccgg 3679321 gtgccgccaa gacgcaacat gatggcctgt acctgctaaa aataccccta atttgatttg 3679381 tttctttttg cttgtcatgg cgatactcct tttatcatgt ttttaggctg aataatccga 3679441 aaaataaact cctatattcc tagtcgttta atatgaataa atcaaaatgt acctttgtct 3679501 tggacgtttg tcaatgagtt aagattaatt ttttctattc aagcgaaaag acccttgcgt 3679561 gaccatgagg gaacggcatt gattcattca actagtgcaa cctctatatc ggcaagaaaa 3679621 ctgagtctaa tgaagcaaag actcagtttt cttccaataa tttcatataa gatttcgcca 3679681 tttcctttgc cttttcttcg cttttgcaaa ccgcctatcc attcagacgc cgtaacgatt 3679741 gtataaaaaa acagctgact ccagatattc aaaccggaat cagctgattg atgtgaatta 3679801 attaagctca tgaatactct cttctgcttt agcggaaaac actttaggct ccaaacagtc 3679861 aaggtcttca tgaaataaat ttactttttg gatttgccga ttgtcatagt ggtggaaata 3679921 gtagtttcca gtttcgttgc acatcacgga agtatattgc gtataatgaa tttcgtcttc 3679981 ttccgttatc actgcgccct ttggtatcgt catatttgcc aaaatttgaa aagcggctgt 3680041 tacacctttc gtttcatcgg ccgccggctc tagatgttct ttcaaataaa cagctctgac 3680101 aaaccgggaa ggcggtgtat aatcccccgg cagaccaaca gttcctaagc cttggccaaa 3680161 agcagaaagg gctaatccgc ccatctcttt gctctctaat tgcttcggtc tgattcctgt 3680221 atattgctgc agattggtta catgccatat aaagtcgggg ctgttcgtca tgacaccagg 3680281 ttgattatca tagactttga ggccgtctgc tcttggttct atcgtcaggt ttcggcccgt 3680341 ccggtctgac aatatccagt gaagcggtaa aactgtatcc aatagatcta attttttctc 3680401 tacaatcgtt aaagatcgaa tcttttcttt tacgtcttcc aaagactgac agactgacag 3680461 cacccatgtc acaaactcat gcgggacaat gtgaacggta tcttcccgta tcgttttttc 3680521 gtactccgca tagcccggaa aataaagcgc cgcacaagat aaaccgcttt cattaatgcc 3680581 gtcggcaaat aatatatttc caagttttct ccccataccg ataaacgcgt actgtgtctg 3680641 atgggccctt ccgtcagctt cactgttcca gctgtaacgg cgcggataga gaatcacctc 3680701 tgtccccagc tgaaatgcaa aatccattgt tcttgctaat acatgtttac ggtcagcagt 3680761 ttccaatgta agacttgtgc acatttgatc agtccccttt tcaattcaga ttaatatcat 3680821 acatattgtg aacgaattgg ttttatcagc ataacgaaag tcaaatcgat tcgtcaaaga 3680881 attgacatta catcaaataa aacgaaaaaa tccagccttt agaaggctgg attttttatt 3680941 atttagccaa aacaagctcg tgaatcgcat gtgcaacgcc atgttcatta ttggagcgtg 3681001 tttgaaagtt tgctgcttcc aatacttctg ggatggcgtt tgccatggca accccgcagc 3681061 ccgcccattc gatcattgtc aggtcgttcc cgttgtcgcc tatgcacatg acttccgcct 3681121 gttcaattcc aagcagctga gccagctggc gtacagcatt tcctttgctg gcttccgagt 3681181 gcagaatttc ataaaagaaa ggcgcgcttc tgaccattgt atatttttct ctcacgtctt 3681241 ttggaatcga tgtaatgacg cggcttaagt tctccggttt atcaataaac atcactttcg 3681301 ggatgaggat atcttttggc acctcgtcaa tcttgcggaa atgaagcggc acctgtgtca 3681361 cataggattc gtatacggta aattcgctaa tatcccggtt aggcgtatac aaattagatg 3681421 agtcaaagaa atgcatcggc gtcttcagct ctaagctcag gtcatataat gaagtcaaat 3681481 catcataacc gagagacagc tctgagacca cttcatttgt atgcgtattt tgaacaagtg 3681541 ctccattata cgcaataaca tagtcgcctt cttcaattaa attcagttca tctaaatatc 3681601 tctgcacacc cccgataggc cggccggtgc aaagcacaat tttgacacct tccgcttttg 3681661 ccgcgtgaag ggcgtcgcgg acctcctctg ttacttcatg atgatcattt aaaagtgttc 3681721 catccatatc aattgcaatt agtttgtaca tcctgcatct ccttcatgtc gttttcaggc 3681781 tatagtccca tcatatcgtt ttttcttttt gatattcaac cggaagagat ggttttctcc 3681841 ggattctgtt tagacgccgc ccttgtcttc ggatacgcaa gcgcggtttc cgctttcttt 3681901 ctgccttgac gccgttttct gcttttttct gtttcatcag cagaaagccg gcagctagaa 3681961 aaggaatgcc ggttatattc aagatggcaa gcttcacacc cgccgcgatg aaaaagaacc 3682021 cccatgaaga tgatggattc cgtctgatca tgacgtaagc cgccatttcc agaacgatca 3682081 ggatggcatg aagcactatg ccataaatca gcaatacaag ggcaaaaaac aaaacataat 3682141 tcacgattgc ccctgagtac atcatagcgc gcatcatttg tataaacgat aaggactgca 3682201 tggagccgct gatgacatta gggttataga tcgtatagtc actaaataaa tgtttgactt 3682261 tgagaaaagc ccataatata aatatccatt gaatgatatg taaaacaagc cccgctgcca 3682321 ccagtctttc agctttttga tttctcatct ttctcctccc tgccggtctt tgattcgatt 3682381 cttgtcatcg tttttctctg tccattttgc tcccatatca atgtcccgtt ttctcctctt 3682441 ttcagcgtgc ttttgagcgg ataataaggg ccgaggtact gaatctcgat agacccgtca 3682501 gtgctttggg aaatcacctt gtatgccata aaaggcagct gtacctctcc tcttccttcc 3682561 atcacttccg tttccacaac ctcgtcttcg gtaaatgtga ctgttgctga tttcacaccg 3682621 tccgttggcc cgggggcacg cccctcatcc cacgttccgt aataaaacgg cgtctcttct 3682681 ttttgctgct ggcagcccga taccatgatg catacagcaa ttaaaaacaa aatgccatat 3682741 ttgtttctca aggggatcac cattctttcc tccttttttg ggcgaatgcc gtgccactgt 3682801 gccaatgact acataagtta taaggaattc acccacaagg agactgatca catgaaccct 3682861 tatcaatatt acagccctca gctgcctcag caggaacctt actatagcca ctatgagtac 3682921 aatccttatc cgcagcagga tgtatacgat ccataccaaa tggacagaca gccggcattg 3682981 gaaagaagaa tcgcagcact tgaacggcaa aatgaacagc agtcaagaga attaacccgt 3683041 ctgacaaacg aagaccgccg tcaaaatcgg gaaattgcac ggattgccga acaggtcaat 3683101 cagttaagcc aggctgttga acgccataca cgccgcctaa atcggctcaa tcagcgcctc 3683161 cgtacagtag aaaaccggct gaatatccca tttactgcag gggaaggcgg tttctgagcg 3683221 aaacaaagaa aaaaagcgga atacgattct cccatctcag ggtttcgttt tccgcatttc 3683281 ttatatgtta aaacggaaca tttacataaa aagggtttgt acccagtata caatctttac 3683341 cgttttcatt caaagataga ggggctgagg aaaataattg tagttcctct ttgacggaat 3683401 ttcttttcat tcaagttgca tgataatacc gactcacgtc aatcgataca tggagggatc 3683461 attcatgcat aatacacaac acggcttgca gcagctgaac caatgccgcc aaactgctca 3683521 gcagctcatt cagcaaacac agcaaagcag ccagcaatat cgccaaatgc ttcatcagga 3683581 acagcaaaac atccaaatgc tgcagcagat tctaaaccac gaacaacaag ctgcacatac 3683641 cattcagcaa gcactgcacg ggcatgacat ggcgattcaa aagtgccagc aggttgtcaa 3683701 catgtgcaac caaatgcaac aggaacttac tggacaatcc agcgtcatga atacgaatgt 3683761 gtctacactt ccattcggcc aaaacacgac atttcagcag caatcctacc agcagtaaca 3683821 tataaaaagc tcaacacaat gcgagtgttg agcttttttt cttactgttc tttgcgaata 3683881 tgtatatcct gaatagactg tttcggtgca tgaaatctgc tctcggcttc acttcttgcc 3683941 tcggcaaaag cccgcgcctc cacatgatct ttgtagacat ccagctgaat caaatacagc 3684001 gggcgcactt taaatccatg aataatggtt accgcccata acgggaccac aataaaaaca 3684061 ccgggcagat cgggcaaaac aaaaccaaac gcaaaaatga aaaaataaat gatgccgtac 3684121 atgatccact ttctatttct aaccttgatg ccaataaata aaaaggcaaa aaaactggta 3684181 atggcaaaag gcatgaaaat aaacagcatc caccagctat gcagccattc ccaagcggca 3684241 cctctttttg taattcccat atttttctcc tcctatttac ctataataat cgattaggca 3684301 caccgcgtca cccataaacg ggaaaaactt tctcccttaa aaatagtgat agacggagaa 3684361 caggtttctt gctatattat taattgataa tgataatcat tactaatcta ttgagataca 3684421 tagtgggagg gttcttgatg aaaaagaaca tattgctcgt gggcatgctt gtgctgcttc 3684481 tcatgtttgt cagcgcttgc agcggcacgg cttctaaagg gagctcaagc gattctgctt 3684541 ccgaaaaaac agaaatgaga acatacaaat caccaaaagg gaacgtcaac attcctgcac 3684601 atccgaaacg catcgtcact gatttttatg ccggtgaatt gctgtctgtc ggggccaatg 3684661 tggtcggctc aggctcatgg tcatttgata atccgttttt aaaatcaaag ctgaaaaatg 3684721 tgaaggatgt tggtgatcca ataagcgttg aaaaagtgat ggagcttcag cctgacttaa 3684781 ttgttgtcat gaatgaagag aatgttgata aattaaagaa aatcgctccg actgttgtca 3684841 taccttataa cacagcgaaa aacgtagaag acacagtcag catgttcgga gatatcgccg 3684901 gagcgaaaga ccaagcaaaa tcctttatgg ctgactttaa caaaaaagcg gaagcagcta 3684961 agaagaaaat tgccggcgtc atcgacaaag atgcaacctt cggcatttat gaaaacacag 3685021 acaagggcga attctgggtg ttcaatgaca atggcggacg cggcggccaa gctgtataca 3685081 atgcacttgg gttaaaagcg cctgaaaaaa ttgagcaaga tgtcatcaaa aaaggagaga 3685141 tgaaacagct ctctcaagag gttattcctg agtatgccgc agattatatg ttcattacgg 3685201 attacaaccc gaaaggcgaa agcaaaacac tcgacaagct ggagaattcc tccatttgga 3685261 aaaatcttga cgctgttaaa cataatcgcg tgtttatcaa tgactttgac tcgttctacc 3685321 cgtacgaccc gatttctgtc agcaaacagg tggatatcat caccgacatg ctgatcaaac 3685381 gggccgaaga aaataaaaaa taaaaaaacg gcacagtcat gacgctgtgc cgttttttat 3685441 gattcacttt aattttgact gtacggagtc cggcatatct tcaaacttga cttcttccca 3685501 agtctcgaca tactttcctt tcgccttcac cttcaaatac gcgttcttcc gaagctcttt 3685561 gccggcgaaa aaggtcactt cttctttttt cccggatgca ttatatccgt ctaatgtata 3685621 ttcagtaccg cccggactaa gatgtctgcc atctcgatca atctgaacat agacatcttg 3685681 ctggtgaata aacggattaa atctgtctgt aacatcgtta tgaaaaaaga gaagcccgca 3685741 tattacggca gcagccgcca agacggccag gattgccatt gcttttttca tctttgcact 3685801 ccccttactt gttcattttt ttcaaatagc ttgaccgcac cgcgaggaag aatagaagct 3685861 gaaaaatgaa aaaccctccg atggtgagac tgagcggccc cgctacatcg gaatatcctt 3685921 ccacagccaa tgttctcaag gcaaacagtg tatgcatgac ggcaatgaca aatggaaaga 3685981 agaaaagaat cgccaattgt attgtcacgc tttgcgccat ttctcgctca ctcaggccga 3686041 ttttggccag tgaacggtag cgctcccggt cttcatctaa atcagtgaac agcctgaaat 3686101 ataagaaact tgctgccgcg acaaagaata caattgcgat aaacaggccg ataaatagac 3686161 tcaggctcgg cagctgcacc gtatcatagt aagtccccgc ttttgaagca aaatcagaat 3686221 gcacgtcgat ataattgccg taaatctcat tttgcaagga ttggctgatc tcaagactgt 3686281 ctttccaatg atcatagctg tagccgtata atgacgcttt atcaccgagt gatttcagct 3686341 gatcaaaggt ttgatcattc accgcgatga tagcattcaa tgagatcagc ggttttttga 3686401 cttcttttac cgacagtttt tgatcagaca gctccccttt ttggttcagc agcttcagct 3686461 gatccggcgc ttcgtttttg aaattgcggt catacgttcc cgggaaatag acagcctcgt 3686521 cttctttcag gccgttcact ttgacatgga agtattttgc cgcatccgat tcactgatca 3686581 tgtaaacagg gggaacagtt tctccttcct gatagcgaac ataggaaaca tctattttgt 3686641 ctttcgtata cgtaaaaccg tgtgttttca gttcatggtc aatatctttc aaatgagtct 3686701 gttcttttgg attgttgctg taagataaat actccatttc ataagcggac tcttccgctc 3686761 cgacggtcga tttgtacatt gcgagcacgc ctgtcgcagt aaacgcaacc gcggaaataa 3686821 tgctgacaat aaagaacagg cgggcgttgt cttttagacg atagacaagg tcagaaaccc 3686881 aaatgatgtt tttcccgcgc agataaaagg ttttccactt cttcagcgcg cgcagaatcc 3686941 atatgctgct ttggctgaaa aagaaatatg ttccgataac ggtgagcagt aaaatgataa 3687001 acggttcggc cccgtggaca ttgcctttaa gaaccatgcc gtacccgccg cacagacagg 3687061 cgatgccgaa taaggacaga agcacggacg gcttaggctc cggtttaacc ttgccagtgc 3687121 cctttattaa tttgataacc gtatttgatc tgacaaaaag gatcgtaaac tgcgataaaa 3687181 agaaaaataa gagcagaaat ccgcaggccg taataccgag cgctttccaa ggcatataca 3687241 aaggcagcgc gtccatttct aaaatataag cgccgaccgt aaagaacgtc tttgaaaaaa 3687301 tgaatcctcc gataataccg gctgcaattg acatgacgcc gatgatcata ttttccgcag 3687361 taatgagctt tctcagctgc cccggcgtga tgccctgcat gagcagaatg ccgaattctt 3687421 tatttctcga tttcaaaaat gcattaaccg aatacagaac aaataagaaa gaaaaaacaa 3687481 agatcatcca ttccgcggcg gttaagcctt ttttggcgat gttattcagg tagccttcct 3687541 ttaatgccgg atgaaacagg aacatcgcaa aggtaaagaa aatcaaaacg gaaaaggcgc 3687601 tgcttaaaaa gaatgcaaga taggcccttt tgtttctcgt gacgttttta taagcgaact 3687661 gaagaaaggt catttgcgtt tccccccagc atagacagca catcgagaat ttgttcataa 3687721 aatacttggc ggttttcccc gcggtaaatc tcattaaaca gttcgccgtc ttttataaag 3687781 atgacgcggc ggcagtagct tgccgaaacc ggatcgtggg tcaccatcaa agccgtgaca 3687841 tgatcatccc gattcaggct ctgcaacgtt tccatgacgt cttttgtcgc tttggaatca 3687901 aggtttccag ttggttcatc ggccagaatg agtgacggct tatgaatgac cgctcttgcg 3687961 atggcggccc gctggcgctg gcctccggat acttcaaacg tccgcttgtt aagcaggttt 3688021 tcgataccga gctttgccgc gatgccgtgc agtttttctt ccattacaga cggcgcttct 3688081 ttttcaagcg ttaacggcag catgatattt tcaccgatcg tcagcgtatc cagaaggttg 3688141 aaatcctgaa acacaaatcc gagctgcttg cggcggaaat gagcgagctt tgtccgcttc 3688201 aggcgatgcg ggttttctcc gttaatcagg atatcgcctg aatctggacg gtcaatcgtt 3688261 gaaatgatat tcaaaagcgt tgtttttccg gacccggacg gccccatcac cgccgtgaac 3688321 tcgccttctt ctattgaaaa tgaaatttgc tttaaggcct gataggacac ttgtccttta 3688381 taggttttat ttatatgttt gacttcaagc atattcgcca tgaaaatcct ccttatggtt 3688441 ttattcttgt tgatctgggc tgctttcatg tagtgccggg acgttcaaca taaaaatccc 3688501 cttgacataa atccatgtta tcaaggggaa acaaagcggg ctatgttgtt ttcttaacgc 3688561 agccttacat ttttgtaaga aatgaaaatc gaactgatgt cccttcaccg ggagacgagc 3688621 tgatgtccac cgtatgattg agcttatctg taatttcttt gacgagatgg aggccgattc 3688681 ccgtagattc ttggaaacgc cgcccgtttt cacccgtgta ataagggtca aacacccgct 3688741 tgatgtcttg tgagggaatc ccgacaccgt aatctttgac ttcaagcacc gtcctgtctt 3688801 catcgcagaa gacattcagc tcaagtctgt cactcttgcc cgctgaatac ttgaccgcat 3688861 ttgtgaccac ttggccaatc gcaaatttga gccatttggc atcggtgtaa atctgatgat 3688921 catcgcaaac gttcattttc ggataaacgc gatattgaat aaaaaatcgt ttatagcttt 3688981 gaataactga ttggagaagc tcggacaggg aaaccgcttc gattttaaaa tcccgttcaa 3689041 acaggtcgag ccttgaagaa taaagaagcg tctccagccc gaattcaatc tgccggactt 3689101 cttttttgat ttgttcaaaa acgggctcat cctcttcttg aatgattaaa ttaatgaccg 3689161 acagcggcgt ctttacttgg tgcacccatt gattcatata cgtcacccgc gcgtcaagct 3689221 tggcttcggt ctcatggagc ttctggtgct gcagccggat cagctccatc tgcttttcat 3689281 acagctctga acagaacact gaagaaccga gatacgggat atccgtccct tcctgccccg 3689341 agctgagcca atgatacacg ccgcggtctt tgtaccagcg ataggcaaga tagcccgcca 3689401 aaataagaag ctgcacgccc aatatgtaaa acaagtgaga aaaagaatga agacccgcaa 3689461 accagtaata aaagaagaca aacagccctt gaaggagaaa aagcagaatc agcactgcat 3689521 gagaccggag aaacagcttc atgactgcgc cctcagctgg tagccttcgc cccgcaccgc 3689581 ttcaatagaa acaggcgcat tcagctcccg cagttttttt ctgagccgcg tgatatacac 3689641 gttaagtgta ttatcatcga tgaatatgtc ggtgtcccac gtcttttcca tgagacggtc 3689701 ccgactcgtc accttttctc cccgctcaag cagcacttcc aaaagcttgc tttctttttt 3689761 agaaagctca cttttttcat cctgaaaacg cagttcaaac cgttccacaa agagctgaac 3689821 gccggcatat tcaaccactt tctctccctg ctttgcggcg tactccccgt acgccctccg 3689881 gatctggctt ttgattttcg caagcacaat atcataagaa aacggttttt cgatataatc 3689941 gtctccccca ttttcaatcg ccatcacctg atccatttcc ccgcttctgg cagaaataaa 3690001 gatgatcggg cttgtggagt gctggcggat ctgccggcac caataatatc cgtcatatgc 3690061 cggcaaattg atatcaagca gcaccacatc gggcttttcc cgcaaaaaga catcaagaac 3690121 agctgtaaaa tccgcggcga ccactgtttg atatccgtat ttttcaaggt aattctgcaa 3690181 tagtccgcga atgtcttcac tgtcttccac aatcatgatt ttattcaaac tgaaccactc 3690241 ccgtttctta cactgctgcc atcatcataa tcgttttggg cgtatggacg caacaccgca 3690301 caaaaaaacc gccatctcgg cggtttctgg tctctttagc cgacctgctg cttagctgct 3690361 ttaccggctg atccgaactc tctcattttg cttcgcactg tctcttccac ggcttcaatg 3690421 ccgggtgtca aatagccgcg cggttcgtac agatcgctgt tttcctgaaa catgcggcgt 3690481 gtttcgtctg tccacgctac catacattcc gtattgatat tgatcttcgc gtggccgagc 3690541 gtgatggctt ttttgatctg atcctgcgga atcccggatg ccccgtgaag aacgagggga 3690601 atatcagtca tgcgggagat agcctccatt tccttaaatc cgagattcgg ctcaccctga 3690661 tatttgccgt gtacagagcc gagggcggcg gccagcgcgt cgatattggt ttctttaacg 3690721 atccgctcac attccgtgat atccgcatag cggaccccgc cgaccagtcc gtcttccatt 3690781 ccgccgaccg tgccgacttc ggcttctact gacacgccgt gttttgcggc ataatcggtg 3690841 acttcttttg tcatcgcgat attctcgtca atcggctgat gggagccgtc aatcatcact 3690901 gagctgaatc cggcatcaat ggcctgtctg cagcgttccg cactgctgcc gtgatcgaga 3690961 tgaagcacga ccggaacggt aatcgccatg tcctctatta acgcgccgac catggcggca 3691021 atcgttttaa atccgcctaa atagtcgacc aggcgatcgg aagccgcggc gatgaccggt 3691081 gattgctcct tttgcgccgc ctgcaaaatc gccttcgtcc attgcaggcc gttgatatta 3691141 aactggccaa ttgcatattg ctcccgcttt gcatcttcaa gaagctcttt catcgataca 3691201 aaagccatat tcacccctcc tttatccatt acatgctgaa gtattttgat acgacatcca 3691261 ctgttgtttt tttcgctgtt tgaatggctt cctcagcagt cagcttatag tattcaggcc 3691321 ggaagagctc aaccgaaaca acatcagaga agccgatttc cttcagtgct gataagtggg 3691381 catctaagtc aattgcccct tgtcccggcc atacacgatc ctcatctgtt aaaaagccga 3691441 ttgggaaatc ttctgtatca tcaatatgat agatgaagat tttctttccg tccgcctgct 3691501 ttaagctctc aatatttgaa cccattgcat ggaagtgaaa actgtcaagg acaagcccga 3691561 cattgtcacg gttaactgtg tttacaatct catacgcctg ttcaaacgta ttgaccgtac 3691621 attgcggatg gccgacaaac tcaagcgcga tttttacgcc gtacggctcc gcgatatctg 3691681 acagctcagt cagcacgtct acactgctct ttttgatctc ttcttttaca atcttctgct 3691741 ctgtcacaag cggaacggcc accacatatt tcacaccgag ggttttgcat gtttccatca 3691801 tgcctttaaa ttcagtgatg atctcgttgt gacccttttc atcacggttg ttgaagaaaa 3691861 cgagtgcgtt taaggcaagc ggtttgatgt ggtgggtttg aaaatattcc gcaaggtcat 3691921 ccaatgaatg atcttttaag tactccggca gcttatccat agtacggatt tcaatataat 3691981 catagccatg cttttcgcat agttctaaat ccagtttaag gtttgagttt tccaatgttg 3692041 tcgcttcatt aaaacaaagt ttcatgccag actcccccat ctgcgtttta gatatgaagg 3692101 gagttcggca ggaaggctgt cgccatatcc cgccgaactc catgctcagc ttatgccaga 3692161 cctaattctt ctttcatttt cttaagcata aatcggcttg attcatccgc tctttcatcg 3692221 acccaagcaa atacggcatt cgtcgcaatt ccgtcgaact tcatctctct cagttttctg 3692281 aaaatcgtat caaaatcaac ctcgccttgg ccaatgtcca aatgctggtg aaccgttact 3692341 ttcgcgtcag gcggattgac gatgtagcga aggccatgag ccgctttatg attataggta 3692401 tctgcaaata aaacatgtgt gaggcggtcg ccggcttcgt caaacatggt ctcgatgtcg 3692461 cctttgccgt catcatagaa gaacgtatgc gcagtcgagt agacaagatt gatccaatcc 3692521 ttgtcaagcg cgcggatcat atccatcgca cctttgtgcg tttcgataaa atcatatgga 3692581 tgggcttgaa gattgagttt aatgccttct ttttcaaaga ctggcagaag ctcatccatg 3692641 gatttgataa atttttcttc acttgttaaa ggatcatatt ttgaaccgct gaattcgctg 3692701 ttcatcaaat ccacttcaag ttcaaccgca atttcgattg cccgtttcca gttgcgcact 3692761 gctgcctggc ggcggtcttc atcgggtccc gcccagtggt aaagaggaag aagcgatgaa 3692821 agcttaacac ctgtatctct taaaaggcgc tttaattgtt tgatctttgc tgaatcgact 3692881 ttcggatatt tataaaacgg gcaaaaatcc tcgcgcggcg ataattcgat atattcatag 3692941 ccgagctctg ccgttttata gaccatttcc tctaaagtta aatcatcacg atacatggat 3693001 ggatccaatg ctaacttcat attttcactc ctctgttttt tagttttgaa ctgttgtaaa 3693061 agattgatag aattccggtt tttccttcaa ttcaaccttt tctttttgtc cagattcctg 3693121 ggcttttaca cacgcgtcag tcgtgacagc agcaatatag ccgtcccatg ccgtcggtcc 3693181 gctgacctcg cctttctttt gaatcgaatc aataaagtct tggatttcca catcatacgc 3693241 agcgacaaag cgtctctgcc aatccatcaa aatatcagtg ctgaatctgc cttcttttct 3693301 caagctgatg cttgatggct cgggaagctt gatgatgccg tcttctccga cgatttcaca 3693361 ttgaatgtca tagccgtatt tacagttcac atagatttca gcattgatga cgataccgcc 3693421 ttttgtttca atcacgacga tttgcggatc ttttaaatgt ggaagcgcgt tttttgattt 3693481 tttcggatag atgacttgaa cggactcgta gtcatcattg acgagccagt ggagcacgtc 3693541 aatttcatga acaagcgtgt cgactacagc catatccgtt gtatagttat ctcctacagt 3693601 cgggttgcgg tgcgcgcagt gaatcataag aggctcgccg atgacatgat tatcgagcgc 3693661 ttctttcagc tgtacgtaac cgctgtcata acggcgcatg aagccgactt gaacaaggcg 3693721 tttgcccact ttgatttctt cttcgacaat gcgcatgcat ccttcagccg ttgtcgcgag 3693781 cggtttttca cagaacacat atttctgggc tttaatcgct ttcagcacgc ttgactcatg 3693841 cgcaggcccc cagcttgtca ctaaaacagc gtctacattt tcgtctgcaa gcaagctgtc 3693901 atcattcgga taaaccgtcg cgtttaattg gtattgctca acgacctttt gtgcagcttc 3693961 ttgattaaca tccgttacag ctacaatttc cgcgcctgac agcttgttcg tgatacggtt 3694021 aatatgttct tttccgattg ctccagttcc aattacgcca atacgtaaac tcattgacag 3694081 ccactccttc tgttggttac atgattttgc tttctgttcc tttctttact tggctctgag 3694141 gagacccgta gagttcctct tgaatttgtt caagcgactt gccagacgta ttcggcgcaa 3694201 agagcagccc gatgatcata ctggccgtca cacatccgag aagaattgca gccatcgttc 3694261 caatgccgaa attggtgata atcattggga caaacagact ccaaatccct attgaaatac 3694321 ggacaaggaa aaacatcagt ccttgtgcgg aagcacgata ttgcgtagga aagatttcgc 3694381 tggcccataa ctgatagttc gcttgctgcc cggctccgtt attgatgccg atcacgacaa 3694441 taaacaggag cagaatcggc aggccttcaa ctggcagcag aaacagtgtc cacccgatca 3694501 ccgccatgaa agcggcgatt ccaaatacgg tttttctata tttgtcggca aagggcatga 3694561 agatcaaggc gacccccaat cctgtgaaga taaacagccc catttgcaaa aggttggcca 3694621 tgttggcaga tacaccgccg acctgctgat aaatgtatgg cataaagaag cccatgaccc 3694681 cggcggctag gttccaaacc aagtacacac ccatcaaaaa caggatgctt tttagataca 3694741 taggcttgag caaatcaaaa tacgatgtct tattcaatac agccggcttc tctgcctgag 3694801 cttcctccgg ctgatttttt gtctgccagg cgtctgattc cggaagcctg attctcagga 3694861 tgtacgtaat cagcgcaatc acaagcagat gggcaaatac gattttattc cccaagagtc 3694921 ccaagtcacc ggccagtacg gagaggagca gtacaacgac agcgcccgcg gcccaagcga 3694981 cttgtgctac gccgcaatgc ctggcccgat tcttctttgg cgcattttcc gcaataatgg 3695041 tccatgacgc ggttatgtca gcccctactg ataaaccgat aatgatgtaa ccgcttaaca 3695101 acatggggaa attaaccccg aacaaaacca aacaaatccc tagtgcataa accagcatac 3695161 tattggtata aacagccttc cgtccgactt tatcagccag aaacccgcca agcagcgcgc 3695221 cgacagcggc agaaatcgca tttgcgctca acgcgccgag cagcccgatt tgcgtatcgg 3695281 atagcttaag gtaactgacc cataatgata aaccggcgga gcctgccaca attgaaccgg 3695341 catcaatata gttggccaat gctgccgcga ttgtccgttt attgaaggct gaatctccat 3695401 tggtattgcc catatgttca ttccccatta agccagatcc aacaactgct gatcaatata 3695461 gtttctcgca atcaatgcat actccagcgg gtttgcaaca tcggggtctt gttcagcttc 3695521 aatgacaatc catccggaat aactgtgctt caacagcagc tgatatactt ctctaaagtc 3695581 aatgcagccg tcaccgggaa ccgtaaacat gccttttaaa aatgattgcc ggaacgattg 3695641 tccttcgagc ctgcattgtt ccatgacatt caggcgggca tccttaaagt gcacatgctt 3695701 aatgcggccg atatgcttct caagcatccc catgtaatcg ccgtcagaaa tatacgcatg 3695761 gcctgtatca tagaggaggt gtacatgcgc agggtctgtt cctgccatca ggcggtccac 3695821 ttcttccgct gtttggacac cagtgccgag atgatgatga tagacaagct tcaagccatg 3695881 ctgagcggca atttcgccaa ggtgattcag cccttcgcaa agccgctccc attcatcatc 3695941 cgtaaagtgc ggcttctctg tgaacacatt tttctccaag ctttgcacgc tgtacgtttg 3696001 ttcagagaca actgcgacat ccgcgtttac ttgctgcaaa tactcacaat gcagggtaaa 3696061 tgtctttgcc gcttcaccaa gtccgtcacg caaaataaaa ctgctgaacc attttcctgc 3696121 aatgcgtaag ttccgaagct tcagctcttt gttcaggatg gcaggttcgg ggaaaaagcc 3696181 cccgacctcc gtgccttgaa aacgtgcgac aacgatatca cttaacaaat gctgaagtgt 3696241 atttcccgct ccaatttcag gcatgtcatc attccgccac ccaatgggag cgattcccca 3696301 caggatttca tttttgccca tctatggtgc ctcccctcta atactgcttc gcagattcca 3696361 gctttttctc ttttgcttcg tatgctttct gaacgctttc ttgttcagat acctctgcca 3696421 ccccgacatg ccaccagctg tcatagccgt ccgtcattgt tttaggcagc accttcattt 3696481 caattaatgt tgatacatcc tgtttcttcg catcctctaa cgcagctttt aattcttcta 3696541 ctgtgtttgc acggtaggtt ttcgcgccgt atccctcagc gactttcgcg taatcgacat 3696601 tcaggatttg gttgtcatct gtgcggaact cgcaatagta gctgccgctg ccgtgatcca 3696661 tttgcaggtt gttgatgcat ccgaatcctg agttgtcaaa gagcagcaca ttgattttct 3696721 tgttgtactg aatcgccgtg atcagttcag aatgaagcat caggaagctg ccgtctccga 3696781 cgattgaata cacttctctg tcagggtggg ccagtttaag accgagtgtc ccggacactt 3696841 catagcccat gcaagaatat ccatactcca ggtgatacgt attcggaaca ttagaatgcc 3696901 acagacgctg caaatctcct gggagtgagc ctgctgaaca gatgatgacg ctgtcttcag 3696961 gaatcgtctc gttgattgtc agcaatgccg ttgtttgcgg aagctccgta ttcaacgcgt 3697021 cagcatattc attcaggacc tcttgagaaa agtgattttt gatttccgga tcaaatgctt 3697081 cccgcttaaa cgtcactttg ctgagacgct cgcgttcagc tagccattcg tccttcagct 3697141 cccggatcgt tgtgccgaac tcgctctcat agccttcaag caagccgtgc agtttgccaa 3697201 gcgtcacttt cgcatccgcc accacttgga atgcatcaag tttatacgcc tgcattcggc 3697261 tgacgttaat gttcaaaaac ttcgctttat caaaatcaaa agcggtctta gaggatgtcg 3697321 caaaatctgt ataccttgtg ccgatgccga taatcaaatc agcttggcgg gccgctttgt 3697381 ttgccgcaag tgtacctgtg atgcccattc cgccaaggtt gttcgcaaaa tctgcctcaa 3697441 cggtagactt tcctgcctgc gtttcaacta acggaatgtt ataggcttca gaaatggcaa 3697501 ccaattcatc gcgcgcaccg gaatattttg cgcctccgcc gacgagaatc acaggttttt 3697561 tgctggattt aatcagctcc gccgcacctt gaagctcgcg ctcgctcggc tgcatgcgat 3697621 caatatagtg aacccgtttg acgaagaaac tttcatcaaa atcgtatgct tccccttcaa 3697681 catcctgaga aatacaaatc gttgccggac ctgcttttgc cggatcagtc atgacttcaa 3697741 acgcgcgcag caaactgctc atcagctgct cagggcgcgt aatgcggtcc cagtatctcg 3697801 atacaggctt caatgcatcg tttgtcgtaa tcgccgcact gtattcttgc tccatttgct 3697861 gcagtacagg gtctggctgt cttgtcgcaa atgtgtctgc cggaatcaag agaactggga 3697921 tattatttgc caatgcagtg ccggctgccg ccaccaagtt agccgctcca ggtccgacgg 3697981 atgtagacac cgcatatatt tttcttctca gcatttgctt gctgtacgcc atggccgcat 3698041 gcgccattcc ttgttcattt ttcccttgat agactttcaa atggcctgca tcctgctcaa 3698101 gcgcctgccc gatccctaat acgtttccat gaccgaaaat cgtgaagatc ccttcgacaa 3698161 aaggctcttc ctttccatct acatggatgt actgctggtt taagaattta atcagcgcct 3698221 gcgcagttgt taagcgaatt ttcttaccca caaacgatcc cacctttact cgatcttttt 3698281 caattatgac tgtgcttcaa taagctgttc gatttcttcc gcagtcggca tcgcttctga 3698341 cgaactgtgc ttgctcacca caatggaggc tgaagcactg ccgtatttca atgccgtttc 3698401 aatgtctttt ccgctgacaa ggccatagat aaaggctgac gcataggagt caccggcccc 3698461 aaaggttttc agcacttttg tcttgtacgc ttgagcgcgg aatacctcgc cggatttgct 3698521 gtatgcgtaa gagccttcga cgccgtgttt gatgacaacg aggtcggctg aatggccaaa 3698581 taaatgattg acggattctt cattgcttcc gcctgtgcgg ttttccatca catcaaattc 3698641 atcgcgtgtg ccgatgacga tatcagactg ctcggcaacc aaagaataat aaacggctgt 3698701 ttcatctgat gactgccacg tatatggccg gtaatccagt tcgaatacca ccttaacctg 3698761 atgctttttc gcgtattgaa cagcttttaa caccgcttcc cgtgacgggc ttttggcgag 3698821 cgctgtcccg gagacaagca gcattttcgc atttgcgata tagtcctcac ttacctctga 3698881 aggctcaaga taaagatccg ccacatcatc gcgatacatt aagatgctgc attcttcagg 3698941 gctgaggatt tctgtaaatg caaggcctgc tttgtgtcca tcttgatcaa caatcatctg 3699001 tgtagtatcc acgccggtct ttctcatata ggactctatg aatcttccat gctggtcatc 3699061 cggaattttg ccgatgaagc ccgcttttaa gccaagcttc gcgctgccga tcgcgatatt 3699121 cgcaggtgaa ccgccgacat atttcgaaaa tgtcatcgtt tcttccattg ggcggttgta 3699181 ttcgactgcg ttcagatcaa tacatgcccg gccgatggca acaatatcaa aagccttctc 3699241 ttcattgaat gtatacttca tcgtaaacag ccactcctca cttgttagcg ttctaaaatc 3699301 cattcatgcg ccgggtcgtt ataaaacttc cattttcgcg tcggccctgc catgacattt 3699361 aaatagtagg atgtgtatcc gtccggaacg cctaccgggt ggtatcccgc aggaacgatg 3699421 acaacgtttt catttcccac agtcattgtc tcgtcaatag aacggtcatc tgtgtatacg 3699481 cgctgaaaca caaagccctg tcccgggtct aactcatggt agtacgtttc ttctaagaaa 3699541 gattcttccg gcaagttgtc ttggtcatgt ttgtgaggcg ggtagctgga ccagttgccg 3699601 ctgtctgtat agacttcaac tactaataga ctgttagctg aagggtctga atccggaaga 3699661 atgttatgaa cagtacgttt gtttgaaaat tgcccgcgat gctcaattcc gttgtcttcc 3699721 gctttgatca gctttgtcgg aagctgcttt tccgatggag aatagcaaag cgccactctt 3699781 gcgtcgctga ccgctgtgat ctcaaatgca cggtcatttg aaatatagac gctgtctgtc 3699841 ggttttcgtt caaatacgct ttcgcgcgtg ccgatattct caaaagtcga ctcatgatct 3699901 gtcactgtaa ttttccccgt taccgccaca atacagattt cttgtttttt caattcttct 3699961 gtatagcttg aacctgatgc aagatctaac actttaaact ctacataagt gagatcagag 3700021 ttggatgtcg ttacttcgtg cacgagtttg accccattag acacttcatg cgactgcggc 3700081 ttacgcaaca aataactcat agagaagccc tcctctttct attggcagaa tgagtccgaa 3700141 cagcgcacat ggacgccgtt cggctgttcg tcgtttagtt gaaatcaggt gccggatatc 3700201 ttgccgtcac cactttttta cgtgtataga agtcgacgct gtcttttccg ttcgcatgca 3700261 gcgttccaaa gaatgaagat ttccagcctg agaatgggaa gaacgccatt ggagccggca 3700321 caccaaggtt gatgcctagc attcccgcat caatgttttc acggaagtag cggattgcgt 3700381 ttgagttgga tgtgaacaag caggcgccgt tcgcaaactc agacttattg gcgatttcaa 3700441 tcgcttcttt caggtttttc acacggatga cagataagac cggagcgaaa atttcatctt 3700501 tccagatcgt catttctgtt gtgacattgt caaagatcgt cgggccgaca aagtagccgt 3700561 cgtcagacac attttcacgt ccgtcacata cgagtctggc accttcttca agaccttttt 3700621 cgatatagct gagcgtgcgc ttcttgttgt cttcgcgaat caccggtcct aagaacacgc 3700681 cgtcatcaag gccgttaccg attttaatgt ccgccacttt ttcctgcagc ttcgccataa 3700741 attcatcggc gattccttct tcaactgtca caaccgcaca agccatgcag cgttcaccgg 3700801 cagaaccgaa ggcagctcca acgatgtttg taaccgtgtc ttcaagattc gcatcgttca 3700861 agacaatcgt atggtttttc gcgccagtca gagattgaac gcgttttaag ttttcgcttc 3700921 cttttttgta gacgtattcg cctactggct tggagcctac aaatgaaatc gctttaattt 3700981 cgggatgctc gaggatgccg ttcacaacgt catgcgcacc gtatacgacg ttgaacaccc 3701041 ctttcggaag gcccgctttt tcaaaaagct caaccaattt ctctgttaac agcggagtcc 3701101 gctcagatgg ctttaaaata aatgtgttgc cgagcgcgat cgccatcggg aacatccagc 3701161 aaggaaccat catcgggaag ttgaatggcg cgattccgcc gacaactccg attgggtaac 3701221 ggtagttcgc cgcttcaacg tccgttgcga tggaagcaag tgagtcaccc atcatcaggg 3701281 aaggtgctcc agcggcgaac tctacgtttt caatcccgcg tcccacttca cctaaagctt 3701341 ctttcgtgtt ttttccgttt tcaatggtaa ttagatgagc aagttcttct ttatgctgag 3701401 acagcagctg ctggaagtta aatagaattc tggcgcggcg aggaaccgcc acctttgacc 3701461 atgttttaaa tgcttcagcc gctgtttgcg ctgcgtaatc aatatcctct tttgtagaaa 3701521 tcggcacttg gcatagcact tctttcgtcg ccggattgac gacatcttca tattgatctg 3701581 ttttgctttc aacccattca ccgttgatgt agttttttaa ttttctgatt tctgccattc 3701641 ttattgcctc cttcattagt aaacacatac acttgtatgg atggttccgg atagattcat 3701701 atcaatatcc acttttcagc aagccaagaa ttaaacgctt tcaaaaacac caaaaaaata 3701761 aatggcggat gcatatttac atacaagcaa ccatttcatg cacaacaggt tactttttgg 3701821 tcatttcttg gttatattct aatcgcataa tacccataag tcaatcataa acactacatt 3701881 ttttcattat ttttattata ttaatctttt aatcaagtaa gagaagtaag agaaggccgt 3701941 ccaatcttgc aaaagatata caccgatgtt atcattttta agcaactatt gattaacttt 3702001 tggtttttat tatatattta tgttacgtaa agattcaaga aggagttttt tatatgaaac 3702061 tgatgcggat tcaggaaatg gaggagtaca ttttatcgca tggcactgtt tccttagatg 3702121 agctgtgcca ggtgttcaat gtctccaaaa acacagtcag acgtgatatc aacaagctaa 3702181 cagaaaaggg tgcgattgaa aaagtatacg gcggcgtaac atctattgaa aaaaccgcat 3702241 tagttccttt tgaaaatcgc accattcagc accaggatga aaaaacaaaa atcgcccatt 3702301 atgcttcccg atttattgaa gatcacgatt tggtcttcat tgattcagga acgacgacaa 3702361 agtctattct tgatacgctt gatccagcca aaaatgtcac catcttaacc aacagtttag 3702421 acattatcaa tgcggcgtca gctttgaaga atatcaactt aatcattatc ggaaacaact 3702481 ataagagaaa aacccgctcc tttgtcggca tggacgaccc ggctatgctt gataagtaca 3702541 atatcaacaa agcctttatg tccgctaccg gaacgacgct gactcacgga ttgaccaatt 3702601 cggatctgct ggagtatgaa attaaaaaga ggatttcaga aaaagcaaaa gaagtgtatc 3702661 tattggctga ccattctaaa ttcggaaaat caacgcttct gacgtatgca ccgtttgaca 3702721 ggctgcattg cattgtgacc tctcagccat tagacgacga gtacacgcag tactgcaatg 3702781 agcatcaaat cggcattcat ctggcctaac gtttacaata gtgttgagag tctatcatcc 3702841 attttattct aggaggcaga tcatgaaaaa agcgaagctc ggaaaatcag acttgcaggt 3702901 attccctatc ggattaggaa caaatgctgt cggaggacat aacctctacc cgaacctaaa 3702961 tgaagaaacc ggaaaagaat tggtgcgcga ggcgatccgt aatggcgtga caatgttaga 3703021 caccgcttac atttacggga tcggccgttc cgaagaatta attggtgaag tgctgcgtga 3703081 attcaaccgt gaagatgttg tcatcgcgac aaaagccgct cacagaaaac aaggcaatga 3703141 ctttgtcttt gataattcac cagattttct taaaaaatca gttgatgaaa gcctgaagcg 3703201 cttgaatacc gattatattg atttgttcta cattcacttc cctgacgaac atacgcctaa 3703261 ggatgaagcc gttaacgcgc tgaatgagat gaagaaagcc ggaaaaatcc gttccatcgg 3703321 tgtatccaac ttctctttag agcaattgaa agaagcaaac aaagacggtt tggtagatgt 3703381 attgcaaggc gaatacaacc tgttaaaccg tgaagcggaa aaaacattct tcccgtatac 3703441 gaaggagcat aatatttcat ttatccctta cttccctctc gtatcaggtt tattggcagg 3703501 aaagtataca gaagatacaa cgttcccaga aggcgacctg cgaaacgaac aggaacactt 3703561 caagggtgag cgtttcaaag aaaatatcag aaaggtcaac aagcttgcgc cgattgccga 3703621 aaaacacaac gtggatatcc ctcacatcgt attggcctgg tatttagcaa gaccggaaat 3703681 tgatatttta atcccaggag caaaacgtgc cgatcagctg attgataaca tcaaaacagc 3703741 tgacgtgacg ctttctcaag aggatatttc atttattgat aagctgttcg cataagaaga 3703801 aaacagcctt ctccaatgga gaaggctgtt tttttgtgcg ataaattcct aaataactga 3703861 ttttgaagca aaaccttaca aaatgagcca taaatccgat aaaataaagg tagtttatct 3703921 cagaaagaaa gtgattgaga aagcaaaagt atgaaacgtt catatcatct agctcatatg 3703981 aaataaagct gacccagctt cttttatttg ctggtcagaa tagcggaccg tttcgatggt 3704041 ctatggagga aacagaatga aacttaaata tgtaaaagcc ttagttgcag taaccgttgc 3704101 tttaggtgta ctgctgccat caacgatttc tcatgcaaag agctttagcg gccgctcatc 3704161 atctagttac agcagccgaa gttcaagctc atcatacagc ggaagctata aatcaagccc 3704221 gaaatcaagc tacagctcag gatcaagctc ttctagcaaa aaatccaaga cgtctgacga 3704281 ttcatcatca tcgatttcgc ttaaaaagaa gccttcggaa aaggcaagtt catcaagctc 3704341 taaaaaatcg tcaggcacct tttccggcgc tacatcaaaa gtaaccggaa agacatacag 3704401 cggaaaaacg tctaaagcct atgttggcgg acgttatgtt tcagtcaatc attactatca 3704461 cgcaggtttc gcgccatcag gatggtttgg atattatagc ggatttacaa tgggtatgtt 3704521 catgatcagc atgatgcacc catggggtta cacctatcat ccagtcggag gccccggtta 3704581 tgtttcttat ggcgcttcac ccattgcctg gatcgttgat atcatcgctt tgattattat 3704641 tttaatcatt gtcatcgcat tgattcgcgc atttaaagca ccgaagacgt acagaaggag 3704701 attttaggca atgagattaa tattaaatga gcaagaaatt gtagacggaa tttgcgtgta 3704761 tatttccaat gaagaagata tctaccctga agacgttgaa gtaaaagaac tatcgtacaa 3704821 caagcgtaca gggttcttcg ctgaagctac atttggcctg caccacaagc agcttatgtc 3704881 agatgacatt tcagaaggca ttattcagtt cttagaggaa taccacaact tcaatccgga 3704941 cgttaccgtc gttgaattgc aatttgataa gaaaaaaggc ttctccgcct tggtttttgt 3705001 caacgaagca gaagaataaa aatgtcttaa tcaaacctta ctccgcgcgg gtaaggtttt 3705061 tttaatggtt tctctgagca taaagttatt tcgtttttcc taaactcagc ggatctgtga 3705121 tcatctcttt tggctataaa gtttccgttt tttcaaaaca aatgtttcaa atgagatagg 3705181 aaatgggtac taatctatta actttgttac atatttttag atactcattg gctcaacaac 3705241 tgaggaggag acatttgtga agaaagacac aaggaaatat atgatctact ttttcggcgc 3705301 tttaggggga ctgctatatg gttacgatac aggtgttatc tccggagcac tcctgtttat 3705361 caataacgat attcctttaa cgacattgac agaaggattg gttgtcagca tgctgctcct 3705421 tggcgcgatt ttcggttctg ccttgagcgg cacatgctca gaccgctggg gcaggagaaa 3705481 ggttgtattt gtcctttcca tcatttttat tatcggtgcg ctcgcttgcg cattttctca 3705541 aacaatcggc atgctgattg catctagggt gatactcggg ttggccgtcg gcggttcaac 3705601 ggcacttgtg cccgtgtatc tttccgaaat ggcaccgacg aaaattcgcg ggacactcgg 3705661 cacaatgaac aacttaatga ttgtcaccgg gattttgctc gcctatatcg ttaactacct 3705721 gttcacaccg tttgaagcgt ggcgctggat ggtcggtctg gctgcagtgc ctgccgtgct 3705781 tctattaatc ggcatcgcct tcatgccgga atcgccaaga tggctcgtga agcgcggcag 3705841 cgaagaagaa gcgagacgca tcatgaacat cactcatgac cccaaagaca tcgaaatgga 3705901 attggcagag atgaagcaag gggaagcgga gaaaaaagaa acgacacttg gcgtgctgaa 3705961 agccaagtgg attcgcccta tgcttctgat tggcgtcggc cttgccattt tccagcaggc 3706021 agtcggcatt aacacggtca tctactacgc gccaaccatt tttacgaagg ccggtcttgg 3706081 cacatcagct tcggcgctcg gcacaatggg aatcggcatc ctcaacgtca tcatgtgtat 3706141 cactgccatg atcttaattg accgtgtcgg ccgcaaaaaa cttctgatct ggggaagtgt 3706201 cggcatcaca ctgagccttg ctgctttatc aggcgtgctc ctgacactgg ggctttccgc 3706261 atcaacagcg tggatgacag tagtctttct cggtgtctat atcgtctttt accaggcgac 3706321 atggggtccg gtagtgtggg tgctcatgcc tgagctcttc ccgtccaaag cacgcggagc 3706381 cgcgacaggg ttcacgactt tggtgttatc ggcggctaac ctgatcgtgt cgcttgtctt 3706441 cccgctgatg ctaagcgcga tgggcatcgc atgggtcttt atggttttct cagtcatttg 3706501 tcttctctca tttttcttcg cgttctacat ggtaccggaa accaaaggga aaagcttgga 3706561 ggaaattgaa gcaagcctga aaaaacggtt taaaaagaag aaaagcaccc aaaaccaagt 3706621 gctgaatgag cgtacattat aaaaaaagga atcgtctcct tatgagacga ttcctttttc 3706681 tgtttacacc atgaccttgc aaatattgtt cgtaaattcc acagggtcct gaatcggcag 3706741 gccttcgatg aggagcgcct gattgtacag aaggtttgtg tacaggctca gcttctcttt 3706801 atcttgttca aacgcgtcct gcagtgtttg gaatacctcg tgatttgggt tgatttccag 3706861 cactttttcc gccttcacat tttggctgtc aggcatcgca tttaagattt tttccatctc 3706921 aattgtcact tcgccgtcag cagcaaggca gactggatgt gatttaagcc gttttgagat 3706981 tctgacgttt ttcactttgt ctgacagaat gtttttcatt tcctcaaaca gatccttata 3707041 cttgctttcc tcttcctcgg actgcttttg atcctcatcc gtgtctatgc caaggtctcc 3707101 gcttgatacg gacttgaatt ctttttcctg ataagaagcc agcattttaa ttgcaaactc 3707161 atcgatgtcc tcagtaaagt agaggatttc atagcctttg tccgccacca tttccgtttg 3707221 cggcagtttc tcaatgcggt cgtaagaatc accggtcgcg taataaatga atttctgctc 3707281 ctctggcatt ctggaaacat actcgtctaa gctgaccagt tttttctctt ttgaagagta 3707341 gaataagagg agatccttca attgatcctt attcgcgcca aaatcattgt acacgccgaa 3707401 tttcagctgt ctgccgaacg acttgtagaa cgtctcgtat ttctcgcggt cttttttcaa 3707461 caggctttgc agctcgcttt tgattttctt gctgatgttt ttcgcgatca gcttcagctg 3707521 gcggtcatgc tgcagcattt ctctggaaat attcagcgac agatcctcag aatcgaccat 3707581 gcccttcaca aagctgaagt ggtccggtag caggtctgcg cacttattca tgatcagcac 3707641 gccattggaa tacagctcca agcctttctc atattccttg gaatagtagt caaacggcat 3707701 gttttcaggg acgaatagaa tcgcgttgta gcgaaccgct ccatccacgc tgatatgaac 3707761 gtgtgtcagc ggtttatcaa acccgtaatg cttttcagca tagaattttt cataatcctc 3707821 atctgtcagc tcgcttttgt tttttctcca gatcggcacc atgctgttga ccgtctgctc 3707881 ttcctgcacc tcttcaaatt cattttcgct gccttccttc ggcttattaa tggttgtatc 3707941 cattttgatc gggtagcgaa tgaagtcgga gtacttcttg atgatcgctt ttaaacgata 3708001 ttcctctaaa aactcgtcat agctgtcatc ttctgtgttc tctttgattt tcaggataat 3708061 gtctgtaccg acagaatcct tttcacacgg ctcaatcgta tagccgtctg cacccgcaga 3708121 ctcccattta taagcctctt cgctgccaag cgctttactg atgactgtca cgacatcggc 3708181 aaccataaat gccgcgtaaa aaccgacacc gaactgcccg ataatgtcat gtccgtcttt 3708241 cagctcgttt tcctttttaa acgcgaggga accgcttttt gcaattgttc caagatgctg 3708301 ttcaagctca tcctttgtca ttccgatccc cgtatcagag atggttaatg ttctcgcatc 3708361 tttgtcagct gcgaccttta tgtagtaact gtctttatca aacgtaagcg catcgtccgt 3708421 aagcgctttg taatagattt tgtcaatcgc atcactcgaa ttggagatta actcgcgcag 3708481 gaaaatttct ttttgggtat aaatggagtt aatcatcata tccagcaagc gtttagactc 3708541 tgctttaaac tcttttttcg ccactcttga tcgctccttt accattatgt aaaccctttt 3708601 cagcatctat ttatcacata agatgacaat tgtcaattag attgatagat gcatatatat 3708661 gtaaatttaa cattagttgg atttgttttc actctttttc tcactcattc tcataaaaaa 3708721 gagaggcttc atcatcctct ctttttttct gtgtcattcc aacggccaaa ctcccgcttc 3708781 atccatatat gcaccgggta gaaaaacaaa ccgaacggta tcaaaaacaa aagattatgc 3708841 catgaagcat tcagaaatgc gcttgcagtc accgggaacg taatctcttg caataaaaaa 3708901 gagatgacag tcagcacaac aaatgcagat ggaatggtca cgatgcaata aaacttgagc 3708961 tccttcttat gctgtacctt caaacataca aacctcccaa caatttctaa ttcatcttaa 3709021 catatgctgg cctttctttt ctcgcatgtt tatcactgca catagcggga agacaaatag 3709081 aaaaaggagg tctcgtatca tgggaagact tgaaaacaaa acagcagtta tcacaggcgc 3709141 cgcgacaggc attggtcaag cgacggcgga ggtttttgcc aatgaaggcg cgcgtgtgat 3709201 catcggagat atcaataaag atcaaatgga agaaacagtt gacgcaatca gaaaaaacgg 3709261 aggacaggcc gaatcctttc acctcgatgt gtcagatgaa aacagtgtga aagcatttgc 3709321 tgatcaaatc aaggatgcat gcggaacgat tgatattctg tttaataatg ccggcgttga 3709381 tcaggaaggc ggaaaggtgc acgaatatcc ggttgacctg tttgaccgca ttatcgccgt 3709441 cgacctgcgc ggcacattcc tttgcagcaa atatttgatt ccgctcatgc tcgaaaatgg 3709501 aggctccatc atcaacacct cctccatgtc aggccgtgcc gcggaccttg accgctccgg 3709561 ctacaacgcc gcaaaaggcg gtatcaccaa cctgacaaag gcaatggcaa tcgactacgc 3709621 acgaaacggc atccgcgtca attccatttc accgggcacg atcgaaacac cgctgattga 3709681 caaattagca ggcacaaaag aacaggaaat gggcgaacaa ttccgcgaag ccaacaaatg 3709741 gatcacgccg ctcggacgtc ttggccagcc caaagaaatg gcaacagtgg cactgttcct 3709801 cgcatcagac gacagctcat acgtcacagg agaagacatc accgcagacg gcggcatcat 3709861 ggcgtacaca tggcctggga agatgctgat tgaggagaaa tggaaggaag aaacgaaata 3709921 agagagggag ccccctctct ttttgtcttt taaagcaata caaccttata tttcttcaca 3709981 tccaaaaact gcaaaaactc cctcgccagc acttcaggcg gatgcgcctt tccttcatcc 3710041 agccgataca aaagcaaccc gataatcatt gcggatacat aatgggcata aagctttttc 3710101 tctgcgtgaa tatcagtttg ctgatgcaga taaaacgatt ccagcgcttt gaacatatca 3710161 ggtatcacat gaggaacacc ccattcccga ttgagaaaat ggacaatggg catgtttgac 3710221 aaagcagaaa gcagaatggc gagcgccttc tccgcttcct ttaaggaaaa ttcattcggg 3710281 ctggaggcaa tcgtcaggtg atcaatgatc tccgcacatg atcgctgtat catggtttgg 3710341 agcaattcct ccttattggc atagtgatca taaaaggttg cacggcggat attgctttta 3710401 cgcgtaatat ctgaaatcgt gatgcccgcg tagtcttgtt tctccgccaa tacatccaga 3710461 aatgccttct gcagcgcctc tctcgttcga accacccgcc tgtcgatttg cttctccttc 3710521 tctcgctctc ctggcacagc ttttccaaac agccaataaa accgcttttg agaaacaagc 3710581 tcccatacct tctggctgat ggcttcagga gacgcggccg catcctcatt cagccaatac 3710641 aggataatcg cgtacgtgta caaggcccga taatgtccat aaatgtcccg ttcaatcggc 3710701 gttaaattca catggatcgg agccagcagc acatcctgct gaaacacatc cttaaaaaaa 3710761 cgatgaaaat gtcctctgtt catcatcaca gaaaaaaagg aacgatgctc atgaacaaag 3710821 gacagcgtcg gatgcaccgt ttgccgtttt ttgttcaaat gaagggtatc catatgactg 3710881 aaggcgtcaa aaagcgcttt gcccagtcct tccttcatgt cttcgatcac atcctcaatg 3710941 attgaaaact tatcctcata ataaaggtag agcgatccgc ggctcacttt ggccttctca 3711001 gcgatttctt tcattgtgat gtgttgaata tctctatctt tcaataaagc cagcagcgcc 3711061 tctttcactt gagcttcggc agattccggc acaaaagaca cctccaatca ttagacagat 3711121 cttagatata tgtacggtaa cgtatagatg gttcaccgtt gtctttctta cagaaaaggt 3711181 accaccttat aataggtccg agaaaagaag aaagcaaatg agggggattt tacaatggaa 3711241 cagcaagtaa aggacgacat ccagcgtgtc tttcagcttc agaaaaaaca gcaaaaagcc 3711301 ttgcgcgctt caacagcgga acagcggaga gaaaagcttc aacgcttttt agattccgtc 3711361 atcgcccatg aagaagaaat catcgaagcg atccgcaaag acgtccgcaa accatatcac 3711421 gaagtcaaaa aagcggaaat cgaaggaaca aaaaaagcga ttagagataa tatgaataac 3711481 ctggaacaat ggatggcgcc taaagaagtc ggttcatcgt taagccctga cgcaaacgga 3711541 attcttatgt acgagcctaa aggcgtcaca ctcatcctcg gcccgtggaa ctatccgttt 3711601 atgctgacga tggcgccgct tgccgcttct ctcgcagccg gaaacagcgc gattgtgaag 3711661 ctgtccgatt tcacgatgaa cacgagcaac attgctgcta aagtaataag agacgctttt 3711721 gatgaaaaag aagtcgcgat ttttgaagga gaggttgagg tggcaaccga actacttgat 3711781 cagccgttcg accatatttt cttcactgga agcacaaatg tcgggaaaat tgtcatgaca 3711841 gcggctgcca aacacttggc atctgtcaca cttgagcttg gcggcaagag cccgacgatc 3711901 attgacagtg aatacgatct gatggacgca gcgaaaaaga tcgccgtcgg gaaattcgta 3711961 aacgccggcc aaacctgcat cgcacctgat tacctgttca ttaaaaaaga cgttcaggac 3712021 aggttcgcgg ggattttaca aacagtcgtc aacgctggat ttatggagga tgatcatacc 3712081 ccagaccgca gcaaatttac gcagatcgtc aatgaccgca acttcaaccg cgtcaaagat 3712141 ctgttcgacg atgccatcga aagaggggcg gaagtggtgt tcggcggcgt attcgatgcc 3712201 agcgaccgca cgatctcgcc aaccgttttg aaaaacgtca cgcctgacat gaaaatcatg 3712261 caggaggaaa tcttcgcatc gatcctgcca atgatgaact atgaagacat cgacgaggtc 3712321 atcgattacg taaatgaccg cgataaaccg cttgcacttt atgtgttcag caaaaaccaa 3712381 gatctgattg acaacgtcct tcagcacacg acatcaggaa atgccgccat caatgatgtc 3712441 gtcgtccatt tcagtgacgt caacctgcca ttcggcggcg tcaacacaag cggaatcggc 3712501 tcctatcatg gggtatacgg attcaaagag ttttctcatg agaagggtgt atttattcag 3712561 gccgctgaat aatcgcatga tcaaaaggcg cttccttaga ggagcgcctt ttattgtaac 3712621 tccttgacca aaagcaattc atcacggata ggtattttat tatctgccag taaaggaatt 3712681 tcgggcttca tctttctggc cgtctcgact gcattcacaa atagtcgatc caaccggtac 3712741 cctctcttct gataaaacgc taatgcatga atattatcat tggttgtgat cagttttatt 3712801 tgtttgatat ttctctctct gcatgcttcc tcggctttct ctagcagagc tgttccgatc 3712861 cctttattct caatgacact atccagcgaa atgatttcac aggcatcttc ttcaaatatg 3712921 tatgtaataa ggccaacaat ctggttatca tcgttgagca ttccataacc atctaattca 3712981 tcgcagttat aaataccgct agaaataacc atttgcggac tgccccagtg tttttgaaaa 3713041 aacgcggaaa caagatcttt aggtacctgg catgtcggaa taatattcat attttcctcc 3713101 ttttagctga acaaaaataa gagaattaac aacctatttt atgtcattaa tccccttatc 3713161 tagtatttac tagaacttat aacttgtcaa aagctgtctg aataccaatt gcgtggattg 3713221 ataaggatca aaatctgaat cctgagattg gaagatttgc tctggggtca atgtctctgc 3713281 gttctctgat aacgtttgaa tcagactttc caaatatcca tttaactctg atttggacga 3713341 ttcatgtagg gattgatgat ttacagcgag ttctctaaat ctgttatcac tgattaattt 3713401 ttttcgaaga gctgctagca tcaagtcaag ccatgcaggc tggccaaatg taatatttaa 3713461 agctaacgtt gcttgatcag atttggtgga gtgccataaa cctcttggca aatacagcat 3713521 ggttcccggt gttaaattaa cgatttctgc atctggcaga tcctcttttg gcggatctcc 3713581 tttccaatat gactgtaaat catcaggata gtaaggagcc tctgataaat catagtgctg 3713641 cattggattg ctcacatttt cattcttggc aagcttccat gttttctcac cttgaatttg 3713701 aaaaatcaag ttggtgtagg cgtcaaaatg ggctttgaat cccccgccat ttttcgccgc 3713761 gtaaacaatg gctttggaag aagtacccgc aggcagtctt aattccgctt tgagtttttc 3713821 tatccacctt ctgacttggg gaataaatag gtcggtgaaa tcaaactcta atgcagcccc 3713881 tttttcatac cactctaaag cctctgcagg tgacacaaga aatctgtctg tgatcccttc 3713941 agattcttca atcacagcat caccaacgac catgactgga ttattgtaga tagccaatac 3714001 gttttctagc gttctaacct tttcaaaccc cggtatgctt gtaaatctct ccacttctcc 3714061 tctggctacc aaaggtttta caggccaata ttcttctaaa aactcactca tcgttacagg 3714121 actgatgata gactccaaaa ccgattcggt tacagcactc atattatccc tcccaaaaaa 3714181 agtaacttca ccacaaagat ataacatttt tttctaaaag taaatattga cagaattatc 3714241 agaggattat aatatttagt tgtgcgtgat agcctatttt tttacaagga aggagggaaa 3714301 aggatgaaaa aggcttataa gaaacctcgt ctttttgaac tgcgccgtgc tgtagcagct 3714361 ggcggccatt aatctcatat agcatttgac atctagtact ctattttagg agggatgctc 3714421 aatgaaaaaa gcttataaga aacctcgcct ttttgaactg cgccgtgctg tagcagctgg 3714481 cggccattaa tctcatatag catttgacat ctagtactct attttaggag ggatgctcaa 3714541 tgaaaaaagc ttataagaaa cctcgccttt ttgaattgcg ccgcgctgta gcagctggcg 3714601 gtcattaatc ttatccaaaa cgattaacgt ttgaggctat cacgccaact tgataaggag 3714661 gatgctgaag atgattacgg ctgaagaatg cagaacgtac aaagaatttg ttgatcttta 3714721 ccaatcctat ctttacccct tgcttggcgc cagactgtcc cggatgtatt cccccaaaaa 3714781 caaagtcatt atcgatatgg gcacaggtcc aggttattta agcattcagt tggctaaaag 3714841 aacaaatgcg cacgtgcatg ctgtcgatat taacccggcc atgcatgaaa tcgctcaaga 3714901 agaagctaaa aaaagcggag taagcagcct gatttcattt gatttggaag atgtccacca 3714961 tttatcttac gctgaccaat atgctgactt catcgtctcc tactcttgcc tgcatcattg 3715021 ggaagacgtt gttaaaggac ttaaagagtg ctatagagtt ctggctccgg gcggaaaaat 3715081 tgtcattttg gatacattta atccccaagg aagccattta gagattatgc gaaaacaaat 3715141 caaagaaccg gaatacttca ggtttgtaag agaggcattt gaagaaagtt attcctttga 3715201 agacattcac cagtttgttc aggatgccgg cattcccaat tattcattag aaacctttca 3715261 ctttttaccg gaggatttta tagaaagctt agatgagctg gaggatgctc ccctgtggga 3715321 acaaaatgat caaagtactg atcatgaaat tgagtctgtc acatggatgt taacgataga 3715381 aaaagaaaag gaaggtgcat tgtaatgatc aatgaatcaa ctgttttatc caaaaatcca 3715441 gaaatgccat caagaaaata tttgaaaagc attattatag agccgggcat cactttaaat 3715501 gaaatggcat cagatattta taaccatatc gacggcaagg tcagcataca tgatatttgc 3715561 tcaaaaatcg tcaatgaata tgatgttgat tatcaaacct gcttagaaga ttgtatggag 3715621 ctgtttgagt tgcttattga tcatgaagca atcaaagtta agcagggggc atgagaattg 3715681 gaaaaacaaa aagtgcttgc tttaccagac gatgtacatg agctgagtac acaccgttct 3715741 aaatcaatcg taaattacat catcactctg cttgcctttg ccaaaaaaca aggattgact 3715801 catcaagata ttgtaagctg gattcacgag caatatgagg aaagaggata ttatgatgag 3715861 tggagacaca ttaacagcca acaaccagtt ggatcatttg tggaactctt tataaaagga 3715921 agacgtttac tttatgacaa aattgaattg tttgaaacag aagataaata tgtcgtaaat 3715981 acccacactt ggtatgaaaa agaacctagt gaggcctttt tttattttga aattgatccc 3716041 gaagaatttt ctgcgtacgc ttccattctc gcaatcgaaa acgcaaaacg tctcggaatt 3716101 aaaatcgata ttgtaaaaga aacagatgta gagacagctt atatctataa acatcaataa 3716161 cgctattggg agggagacat atgtgcgggc tcgcgggtat tataaatctg gctgctcccc 3716221 gttctcagga atgtaccttt catatattga aaggcatggc agatgccatc agctataggg 3716281 gaccggatga tgaacaatat catattgatt ccaaagtcgg ctttgcattt cggcgattgt 3716341 ccattcttga ccttgtaaat ggacagcagc cctttttaaa tgaggatgga tcaatcgtcg 3716401 ttatggtaaa tggagaaatt tataactata aagaactgaa ggcttcttta cacaatcata 3716461 tgtttaaaac gacatctgat tgtgaagtaa ttgttcattt atatgaagaa aaagggattg 3716521 gatttgtaga cgacatcatc ggaatgtttt caatagccat ttgggacaaa aataaaaaca 3716581 aagtattttt agttcgtgac cgctttggga ttaaaccgct tttttacaca gagctaaaac 3716641 acgagcttat atttgcctct gaaataaaat ccctattttc tcatcctcac tgtccccgcc 3716701 aatttaattg gaaagaagca ctctcagaca tttggctaag cggggaagca gccagtaatc 3716761 ataaagaaac cacttccttt tttgtaaaca tccaaaatct cgatgctggc cattatctcg 3716821 aaattaattt gacaacaaat gaacgaaaaa cagcaagcta ttggtcttta caggatattt 3716881 tgctcaggca aggctatcgt gagaatctcc atcccgatga cctgattgaa ggatatagag 3716941 aactgctggc agattcagtc catagatgtt tacaaagcga cgttgaagtc gggttgtttc 3717001 ttagcggtgg cattgattca gctgcagtcg cacattttgc tgcagaaaaa caggatctcc 3717061 atacgtttac agtattaagc caaagtacat ttacaaatga agatgcaaaa tatgcccatt 3717121 ggctggctaa agatttacac cttccaaatc atcaggttct ctatcaatta gggaacgatg 3717181 agttattaca accagagtca tataaacatt tgttatggat ctgtgaaaca ccgttttgcg 3717241 gaccggaaca attatataag tttcatttac ataagtatgc caaagcgata aggccaaacc 3717301 tgaaagtcat gctgaccggc cagggcagcg acgaatttaa cggcggttac agcacgacac 3717361 tttcaccagc cgagaaccca agttgggaag gatttattga atcggtcaat acgatggaga 3717421 tgaaccggct gcatcggctg cagggaaata tctttagagt gtgggaggag cattttggac 3717481 tttctcctat aaacctttct tatttaaaga gcaatgattc cagccaagca gatccttggc 3717541 aatcgtatgt cctgacaaaa taccgtgatc tgcaaatgta taattgctgg catgaagatc 3717601 ggatcgccgc ggctaatcat atcgaaaacc gtgtaccgtt cttggaccat cggcttgttg 3717661 aatgggtttg cggaatacct gatggactcc gtaaagactt gttatgggat aagtcggtat 3717721 tgcgaaaatc attaacaaat gagctgcata caagctatac ccaccggcca aaggttcctt 3717781 ttttctatgg taaggacgtg agatatacac ataaaatgat gtttcatctt ctgaagaaaa 3717841 acaattatca gcttatagag gaggccttct ctcacagcga tgcctccagc ataatacagg 3717901 ttgaacacat tcatgccatc atgacatatt tggaggatga tcctgagttt acaaattttg 3717961 aatttttatt aagactggtg aacatgggac ttttatcaaa aatgactaaa gaaacccctt 3718021 ctgttcaatt agacataacc agccatttag aatcgataac aataaaagac tggcactcac 3718081 aggaaggtga tattgccagt cgtttaaata tctcagccaa taagtgtgaa ggacaagata 3718141 ttttggcgct aaaccctggc gtcactctgt taaggccgga aagcgatagt gagcattgca 3718201 tctacattgc ggaagaagga tttattcagt ttattgtttc ggaggaagac gtcggagctt 3718261 ggctgcatat tctctgcgat attaatggaa aagacacact tcatacgatt ttagacagac 3718321 atggtgtcag ccttgaagaa gtggccaaat atattcaaga agccatcgaa cacaatatca 3718381 ttttgatcaa acaaaaaaat ctgccagaag gagcatatag atgagcatct tttattcgtt 3718441 ttccgcactt aggggattag caatggggat tttttcgcct atttggattc tttatctgat 3718501 atctaaagat tatgatttcc ttcagattgg attaatggga gcggtacttg aaattgctaa 3718561 gcttatattt gaagttcctt ccggcgtttt tgctgatcgt tatggaatta aaatttcaat 3718621 tgccagttca ttctttttct ccatccttac atgggccttc ttccctttta tcgattcagc 3718681 tgctatttgc atactggcta tgatcatatg ggctttatca gattccttaa tttccggttc 3718741 ttttgaaact tggatgagcc gtgtcgcagg ggaagatcga ttcggcaaag aaatgatgaa 3718801 aaacacacaa ttgctaatca cttttttaat tattggaagt attgccagcg ggtatttgta 3718861 ttcattaaat atctattttc ctttcctgct cgttatggtg atctacttat tactatttat 3718921 ttggatgtct gtatttatta aagtcccttc tgtttccgaa acaaatcatg gggatcagaa 3718981 ccaacatgat tcgataaaga ttatcaaaga aagtttaaaa attatcttta acaaaaaaag 3719041 ggttctttta atcgtcatag ccggtttctt tacagccaca gcctatgaca caatttcccg 3719101 ttactggcag ccttttttga gtgatttagg cttttcagaa aagtcactgg gatatatttt 3719161 tgccctagga gggtttaccg ctctcgttct tttgacatta accatcaggt tcgaaaagaa 3719221 gatcgaaaaa aatccatatc tcgctttaac ctcattggat tccatgggca tggtcatgac 3719281 ttttctattg tctagagcat tcaggccgct gggcattcca tgtacagcgt ttttgcttgc 3719341 aattgaagat attcatcatc cgatcgtaac aagttactta aataagtttt tccccgattc 3719401 atacaagaac acacttttct cgttaaactc aggggtagga gcaattggag aaattctttc 3719461 cggtgtcatt ttcggcatca tttccgcagc ctttgggctc tctgccatgt ttgttgttgt 3719521 agctgtattt ctattaatcc ctattatcct ttatacgata gtgcctaaga ttaaagacaa 3719581 tgatatgaaa gttcagattg aaaaatccca gcaagtgtaa atgttttgta tcacagtaag 3719641 aagaccttct tattaaaaga aggtcttctg ctattctatt cagttatttc ccaaaagcca 3719701 tcagcttcgt ataacttcca atataaagtg ttccgtcctc agcgagctga ggagaagaca 3719761 cgacgttgct gtcggtttga tagctccata attcattgcc gtttgcgtct gccgcataaa 3719821 ccttcatatc atctgacccg aaataaaccg ttcccttcgc gtcaatcagc ggcgccgttc 3719881 tgacagggcc gtctgtgtag aatgaccagt tcatatcccc gtttttgctg atggaaaaca 3719941 gctcgccgct tcctgagccg atgtagatat tgccattatg atcaatcgca ggagatgagc 3720001 tggagaaccc gtttagcggg aatgtccatt tcaaactgcc tgttgatgta taagcataca 3720061 gctgtccatc ttggttgccg gcataaatgt ttccgtcctt atcaatcacc ggatatcctt 3720121 taaacgcatt tgacgtcgtt ctggaccatt tcacctgtcc ggttccggag ttgatcgcat 3720181 aaaacacgta attatatgtg ccgacataca cggtgccgtt tttggcaagc accggcacag 3720241 agctgacgac cccatttgtt ttcaacttcc agcgctctgt ccaggttgat tttgacgtcg 3720301 gtttgatcgc gtgaacataa ttatcaagtg ttgagaaata caacgtcccg tctgaaccga 3720361 tcaccgtttc agagcttggc ccgccgctta acggaaccgt tgttaaaatt tctcccgttt 3720421 ctttgtcaat aaaataaatc tttttgtcat aggatgccaa atagataacg ccgttggtcc 3720481 caagtacagg agattgcgta tatgtttttc caagattgcc cgtcacccat ttgactgagc 3720541 cgtctggatt aaaggctttc atttccccgt ctctggaatg aagatatact gtgccgtctc 3720601 cgtcaatcac agcccccgct ccattttgcg gagtcgttct gatgtcgttt tgccatttca 3720661 gcgtcccgtc tgtatttccg gcgaaccggc tttcgcgtga ccagttaaac atggcaggcg 3720721 ccatcgcttg tacatcatat cttcctggca aaaagccaga tgctccatta ttttgagaaa 3720781 acaccgtttc cgccgcataa gcagctgtcg gctgaagcac tttggcagcg ggcacatcag 3720841 aaacagcgcc ggccgaaaca gccgccgcca ccgcagctcc cgcaatcaaa gctttcatac 3720901 gaaatgactt gaccatcatt gagaccccca ttatatgtaa cttctaattt gtgaccatca 3720961 taacatattc atccatttta taaatctatt tcacaaaaac atcacaaact agaaaactat 3721021 gtaagagtat tcacggacgt tttttcagca cccgatcgaa atgcagccac aaaccaaatg 3721081 acgttgacag cagccgcagc gagactaact cccaaaacaa agatcacctc agaaagcaga 3721141 tggtcactaa agaaactaaa catcaagata aaaccggccg aagacaaatg aatcaaaagc 3721201 ccgaagccgc aaagcaccgc catgacatac ctcattgcat cgactccgag catataaacg 3721261 agaaatggaa tgaaatacaa gacaaggatc ataccgacag ctgaccacat gccagctgaa 3721321 ttaaactgat tggccgccgc tcccgttccg gccagcggcg aaagtgaagc cgccacaatc 3721381 acggcgcaaa aaagaaacgc agaaatggtt gtcatgatcg ccacgctatt tttttttgac 3721441 atcaaactcc tcctttaata gaaatattaa ccttttttat tataagtaag ttgaatgtta 3721501 tattcattat atttttaaaa aattccagaa tacatacaca aatgctatgc ttctttctag 3721561 tatatttata tagtaaaaaa caaaggataa aagactcatt tttctgtaat atcaggattt 3721621 tatcaccata ccatattgca tgtacatgtt tttcaaagta tactattcca gattaattca 3721681 gaggagagag aaaaatacat ggaaaaacca gcaggatttt ggattcgttt tttagcttat 3721741 tttattgacg gcattattgt atctgttcct agttatatta ttctatttat tatcaattct 3721801 gtgtttgtag ctggggctgt ggcaacaaac ccttacatga cggaagaaga gtatttagtg 3721861 aaatacatga cgcttgcatt tttgcctact atgctgatca tgatcgtcat cagcgtgtta 3721921 tattacgggc tgctcacagc ttctaaaatg caaggcacac ttggcaaaaa aattcttggc 3721981 ctgaaagtgg tcaatgaaca aggtgaacgg gtttctgtcg gacagggaat tggccgttac 3722041 tttgcctata tcttatctgg aatcatcttt tatatcgggt ttatcatgat cgcctttgga 3722101 gagaaaaaag gcctgcatga catcatttgc aaaacacgtg tcgtgtataa ataatagaaa 3722161 aaagtctaga cgccaatagg catctagact tttgttttct ttgcaatagg ctgccacgac 3722221 agatacgtag cgcttctcca caaccactca aacggcccca tccgaaagac acgaagccaa 3722281 aggtggctga agaccatttg aacggcacaa acagcaattg taatgagcac accggcagca 3722341 gggtacactt ttccatacag gcccaagccg taatgataaa aaatccaagt acacacaata 3722401 gactgcatca aataattggt aaatgccatc ctcccaacag cggagaatga ttgcagcact 3722461 gttctcactc ttgttttatg ataaagatag acaaccgttg taacatagaa aaacatgagg 3722521 aaaggcgcgc caatcagcaa acatatttct ttatccgtta cactgtacag cacctgggcg 3722581 ccgatgccga tgacaagccc agccatccat aatcgtttta atcctttgcg atgcttttcc 3722641 ggttcatgca aataccgtga ttttgctgcc gcagctccca gcaaaaacat gctgaaatat 3722701 ggaatggatg caaagaagta gttgagcgga ttatacgtaa gcatgccatt cgaagacatg 3722761 taaacaagac ggtcgtggat ccgctgttct gcaatatcct tcaggctgcc gcttccataa 3722821 acatgaatcg cttgttttgc ctgctgtgtt accgcttgta cccattcctg tccgtttgat 3722881 tgatcaaaac ttgtcaacat gaacggaatg gaaaacagaa gatacaaaga gaccgcccat 3722941 atcagcagtg ttttcggctt tgcttttcga aacaagagca ggacaaatcc gagcagggca 3723001 tattctgtta aaatatcccc gtcccatatc aaaaaggcat gaatcgttcc aaacaagaga 3723061 agcgccatta accttctcac atataacgga acaaaccgtt tccctttgtt ttctgctctc 3723121 tccatcatga caaccatgcc aaatccaaat aaaaaggaaa acaataaaat acattttgtt 3723181 tgaatgaaga atttcagtat gtctgcggcg gcaaaatcag cttcagacca cttatccatg 3723241 aaaaaattct cttttccaag catagacaaa tacatatccg gataactgaa atgtgccaga 3723301 ttgacaaata agatgccgaa aatcgccatt cctctcagca catcaagcac accgatccgc 3723361 tcatttgtta aagtcggctg taatgaagac atagccatca cgctcctttt ttctgtacct 3723421 taagggtagg aaaaaatgaa gcgcggtaac atcgatttag gtgtcaggcc ggcatgaaaa 3723481 ccttacaatc ttgtcatctt tatggtttca tcacctttaa atctaatgct tcgatattct 3723541 gcaaaatgcg atcaaagcgc aaagcctgag gctcacatgg gaagatgtgg ccttcatacg 3723601 ggtcgcctaa cgtccggaaa aacggttcaa ataaaccagg aaccaatacg cccaccatct 3723661 ttgtatagtg agaatcaagg cgataggagt gaacggtatt tgcagggaca tgcaggaaat 3723721 ctcccggatt cagctgaatt tcctggccat ctgtccacat cgtcatctgg ccttcaaggc 3723781 aataaaatgt ttctgtatga tattcatggt agtgatcaac gattcggtca cctttagggc 3723841 cttcagatga tacgacgata aactggccat ctgtattttt ttgtgcagcc acaatgcggt 3723901 gaagctgatc tccagtcaac agacgatctc cttctccaga ttcaagaacg tatggaaccg 3723961 ctccatctgg cagctctgta agttccgcta atttggccga acatgcaggc tttgcttcat 3724021 ctagaaatac aatgtccgct acagcggctg cttctgcaaa tcgctcgttt gagacttctt 3724081 cgcttgcgta cggcggatgt tcagcgtgat catacggatt cccaataacg gaatacaagt 3724141 gcgctacgtt tcctttcatc gtgtaagaca ccagtcttgt tctgtggctc tgcatccggt 3724201 agctgtgcgg tgttcccgcc ggaatgttgg cataatcacc tgatattaat aaatagcgtt 3724261 caccatcaag tgtcagttcc agtttcccgt ccaaaacgag aattccttca tgtgtgtcct 3724321 tgtggacgtg aagcggaaag gcatctcctt ttcccccgga aagaagcacg atctcaaaca 3724381 aatcacctgt gctcctccca ttcgccatca ccgtggcaac ctgtctgccg aacagatagc 3724441 gctcgccttc tccgctccgg agcaaataag gcattttttc tttaggcaat gaatgtgtac 3724501 ataatgtttt catattatcg cttcctccaa tttagaccag tctatatatt atcattcatt 3724561 tgtctagacc gttctatata attgtaggag aaaggataac aaaatgctac cctttttttc 3724621 tcaccagcac tggtatttgt tcggcaatga gaagaagagg cgttttgtct ttattcgtta 3724681 acgaaagcat gatgccgccc tcaatcatcg aattaatcag cgttccaagc tgatttgctt 3724741 cttcttctgc aaatccgttt tccattaatt ttctggcaaa aaccgcttcc cagcttttaa 3724801 acaccttcat gcaaaccgtc cgcagcggtt cactgattaa cgctgtctca ctcgccagca 3724861 aaccgactgg aataccttta atgctttctg tgttgtcaaa ttggctggct gtttttttga 3724921 taaaaagctg aatcgcttca acaggatcag aggattcatc catgctttgc tgtatcagat 3724981 gttcaacgat cttacctgta tatgtaaccg cttcaattgc tagttcttct ttgccattcg 3725041 gaaaaaagtg ataaagcgat ccttttggag caccgctttc ttttacaatc tggttcaaac 3725101 ctgtcgcgtg atatccttgc agctggaaca gacgtgacgc cgtgtgaagg attttttcac 3725161 gtgaatctcc tctgctagtc attaaaacat tccctcctag gtatggtaga gcgacttata 3725221 taatataaaa aagaaccctg tgattgtcaa aaggggtaag acccttccgg atggggtaat 3725281 gtacaaaaac agcgtctagg agggatctct caatgacaat cgatcattca gtcacaaata 3725341 cagagcagct tgaacaacag aaccccgcca taaaaacaaa gctcaaactg aaaaagctta 3725401 aggatcaggt gatcgtcatt accggcgctt caagcggtat cggacttgtc acggcgagaa 3725461 tggcagctga aaaaggcgca aaggtcgtgg cagcagcgcg aaatgaagag gcgctgaagg 3725521 agctcactga tgaacttaag gaaaaagggc acgacgccat atgggtaaag gcggatgtcg 3725581 gaaaagaaga ggacgtcaac cgcatcgcag aaaccgcgat cagcacattc ggccgctttg 3725641 atacatgggt caacaatgcg gccgtctcga ctttcggaca cgccatggac gtcaccgtcg 3725701 aagacatgaa gcgcatgttc gacacaaatt tctggggacc tgtttacgga acaagagcgg 3725761 ctgtcaaaca ctacaccggc agaggtgtgc cgggcgcact cattaatgta ggaagcctgt 3725821 tcggagacag gggaacggtc attcaatcca catatgcatc tgccaaattt gcgcttcacg 3725881 gctggacgga aagcatccga atggagcttg aaaaggaaca ggcgcccgtc tcggtaacgc 3725941 tcatccaccc gggcagaatt gacacaccat ataacgagca tgcgcacagc tacctcgaca 3726001 aacagccggc tcattaccgc tccatgatct atccgccgga agcggtcgcc gaagcgatcc 3726061 tgtttgccgc cgaacaccct aagcgcgaca tgtacatcgg ctcacaggcc aaagccatcg 3726121 ccatgctggg cgcgcttttt cctcgtctga ccgacagact gatggaaaaa atcatgtatc 3726181 acagccagca tgccgaaaga ccgtccaatc cgagagaaga aagcgctctt tatgatgctg 3726241 gctgcggtat gcatgacaga ggcacaaata aaggatggat gaggtcaaga agctactaca 3726301 caaaagcgac gaagcgccca attgtatcgg cggctgttgt tgccggacta gtggcttggg 3726361 ctgccgccaa acgatgcaga taatctctga ccataagaaa aacccatgct gttccagcga 3726421 accatgggtt tttcagctgt taatcgataa aagccttgtt catacgctgc agcagctcgc 3726481 cgaacatctc tttttcctgt gttgaccatt ctttcagcat ctgttcataa cgttcaaggc 3726541 gcttttgctg atcggctttt aatagttgtt tgccgagttt tgtaatggta aacaggctga 3726601 ctctcccatc agacgggtct gagaaacgat agatgagctc ctttgcctct aatgcagctg 3726661 cttgtcttga aagagtagaa atatcaagct taaacgattc agccaattcc ttaacacgag 3726721 caggcccaaa ctcatccaat tgtctcagta ataagtacga agatctctcc aaattccctg 3726781 ttcttttctc cgattgatcc agataaacag ctctcctgat aaaagtcgtc agctcatatt 3726841 caattaattc aactggattt tgattttgca atcgctctcg ctccctattc caatctccgg 3726901 cattgacaac atcatatata cttgtataat acaaatgtac attaactgaa taaatacaag 3726961 tcgttatatg actaaatcaa ttattatact tgtatagtac aatcatataa aaagaaagta 3727021 aagcgattcc tcagaaccat cctagaagca agcaccagaa aggaggaagc tgttctgatt 3727081 ggagagcagc acttgatgtg aaagtcatac gaattatttt gcaagtgttg atattatatg 3727141 tattttttat gatcggggaa gccattcagc atctgtttca tttacccgtg tcaggaagca 3727201 tcgttggatt ggtattgctt ctgatctgct tgggcctccg tattgttccc gtctccatca 3727261 ttgaagacgg agcagggttt ttattatcct tccttccatt gttgttcatc ccggcaatga 3727321 caggagtgat aaactatccg tctctcattt cattcaatgg cctgatgctg ctgattacag 3727381 tcgttctcag caccatcgtc acgatcattg cggctggatt cgccagccag ctattagaga 3727441 aaaaagcaaa aaaacgggag gagaaagaga aatgcagcaa gcatgtatcg cgatcattat 3727501 aattctttta acagttgccg cttatttagc gatggtcaaa ctctataagc gattcccgct 3727561 tccatttctg atccctgttc tgacaacgac aattttgatt gtagcggctt tgatgatgtt 3727621 tcatgtttcc tatgaaggct atatgatcgg ggggaaatgg atcaattctt tgcttgggcc 3727681 ggctgttgtg gcgctggcct atccgcttta taagcaatgg catatcattg tcaaacattg 3727741 tgttcccatt ttaggcggcg tcctggtcgg cttatgcatg ggaatgatca gcgggctgat 3727801 cttcgcagaa gcattcggga ttgatcatga tctcttatta tccattctgc caaaatcgat 3727861 cacaacccct gtcgctattc agatcgccgc cggtcttggc ggcgtccctt ccatgacagt 3727921 cgtatttgtc atgattgcgg gcttttcagg cgtcatcctc gggccgcttt tcctaaaatg 3727981 gcttcgcata cgcagctccc taggacaagg cattgcatta ggcagcgcct cccatgcact 3728041 gggtacctcc aaagcgttgg aatatgggga attggccgta tccatgagtt ccgtctccat 3728101 gacgctttgt gcggtgctcg gctcattctt cggcccgctc gtcgtctggc tgtttcatat 3728161 ttaacaaaga aagactgccc cgggggaggg cagtcttttt cgtttaagaa gcaaaaaaat 3728221 caatcaacgg ctgaaagtcc ttagataaat caacgtcatt cggttctgct tgaagcaggc 3728281 ggtcaatcat acgctccagc tcctcaacat cattcttatc cgtatattca atgaagttta 3728341 agctttcaag ccaatcccga tatgaatgtt tggctttgcc atagctgttt ccaaagacaa 3728401 ggcaaggtgt tttggtgata atcgagaaaa tcatcgcgtg aaggcggtcg gtaatcacca 3728461 atttactgga gccgatgcgg tccagcatct ccataaaatg cttttcacga tcagcgtaat 3728521 cgatggtgtc taccgtatcc agcaccgtat cggtacgctc tgtgtaagtt gttttttctg 3728581 cccattgctt catctgtgaa ataaaatctt cgtcagtcac tttctcctta tccgctctta 3728641 aaataaagag aacgccgtcc cgctcgagct ctcgcggcac aatatccaag gaaagcacca 3728701 tgtccggtgt aaagatcaca ttggagttga aggtctcttt cacaacatcc agtgtttgcg 3728761 tctcacgcgc agcaatcgtt aagtttgtat tttgatggta cgcatcctgt gtttttttct 3728821 tttccttctg tccttcctct gtatcctcaa aataaacgga ttgtggcaga gaaattgatt 3728881 tgtagtcttt aaacgccgaa aagacctttc ttctgtcttc ctcaatatcg agataaaggt 3728941 ttcctaaatt ccctccgcct gtaaagcaga caatatcgtc ttcacgaatg atctccttca 3729001 ccagttcaat gccctcatcc gtcgcataat ccataatctc aatgtattca taatacggaa 3729061 aatgattttt gataaatttc tcttccgcat acgcaatcgc ttggtcgcca atgtttgtgt 3729121 agctagggga accaaacaaa aatacttttc gtttatcatt taacagagct tccggctcca 3729181 catttggcgc aatgcctttt actagttttt tgcctttgat ttcttgtaca gtcatatctg 3729241 cgtcctcctt ctgggatgaa ttcctcattg tgtgttaact gtctctaccc aaaaagaagg 3729301 atggctatgc attggcatgt gcatcggcta tatcagaaac atcgttttcg ccaatttgat 3729361 agacgctgca atgtcccgcg ccgttctttc catatattcc gcggcatgtt caaacgcgtc 3729421 ttctagtggc acggctccgg ggacgatgct gaaaagcgca tcgattccgt gttgatagac 3729481 ggcattactg tctcgggaaa ttgatcccgc aatgccgata acgggcacat cgtatgattt 3729541 agcggccttg gccaccccga tcggtgtttt tccatgaacc gtttggctgt cgattcgtcc 3729601 ctcgccggta atcacaaggt ctgcatcctg aacgatactt tcaaaatcaa ccgcttcaag 3729661 gacaatatca atgcctcttt tcaggtcagc ctgaagataa gttagcaggc tccatccaag 3729721 accgcccgct gcaccggcgc cctctgtatc tcggaaggtt gatccgagcg ctttttctgc 3729781 catatcagcg aaatggctta cgttctggtc tagtacatcc aacatgtcgg ccgtcgcgcc 3729841 tttttgcggc ccgaaaacag ccgtagcacc ctttggtcct gttaacggat tgtccacgtc 3729901 acaggcaact tccagtttga cattccgcaa tctggaatca agcccgctca catctattga 3729961 tgcaagctga gataacgcgc cgccccctgg gccaatctcg ctgcctgagt tatcaagaag 3730021 ccttccgccc aatgcctgaa tcatcccggc tcccccgtcg ttcgtggcgc ttccgccgat 3730081 tccgatgatc aatcgctccg ctcccgcatc aagagctgct ccgattaatt ctcccgttcc 3730141 ccttgttgta gtgatgagcg gatttcgctt atctacaggc accagatgca gccctgaagc 3730201 agcagccatt tcaatcacag ctgttctccc atctcccatc atgccaaaga aagctctcac 3730261 cggttccccc agcggccctg tgacaacttg ctctatgatc cttccattgg tcgcatcgac 3730321 cagagattga acggttccct cgccgccatc cgccaccggc aattttctgt aatcagcacc 3730381 cggaaagacc gatttgaaac ctctttctat cgcttcggct gcctccagag ctgataagct 3730441 ttccttaaaa gaatcaggtg caatgatgat tttcatccaa atcgcctctt tcaaaacatg 3730501 attcacttaa cctattgatc tccaatgtac cataattgat ctggaaatac ataccatgca 3730561 atatggtaaa aatttaaata aaaattagaa atgaaagtgt ttgcataaaa gaaatattca 3730621 cgttatcata cttgtataca agtatactcc ttgagtgagg aaggtgagtg tatgctagac 3730681 tccaaagacc tgttgtatcc cgcaaaatgg ctctcaaaag cgtcaaccgg agttcgtgtc 3730741 gcatacgagc tgagaatgcg gatcgtttca ggtctgattg aaagcggtac cattttatca 3730801 gaaaatacaa tcgccgccga gttttcagta agccgttcgc cggttcgcga agcgctaaaa 3730861 atactcgcat ccgaaaaaat catccgctta gaacgaatgg gagcggtcgt aattggttta 3730921 actgagaaga aaatcgcgga aatttatgat gtgcggttac tattagaaac atttgtcttt 3730981 gaacggcttg tcaaaataga cattgagcct ttagttaagg atctcagcaa aattcttgaa 3731041 atgatgaaag tctcaatcaa atatgaggat gctgacgaat tttcatttca agatgtgctg 3731101 ttccatgaaa cgattatccg agcgattgat cattcataca ttcagatgat ctggaacaat 3731161 ctaaaacccg tcatggaaag ctttattctt ttatcgatgc gggtacggtt aaaggaaaag 3731221 tatgaagact tcacaaggat tttagataac cacgagcttt atattcaagc catcaaaaca 3731281 aaggataggg cgctgatgat tcagtctctt caccaaaact ttgatgatgt gcaggataag 3731341 gtagaagacc tatggctctc acaacaaatg ctggcaaaag gagctgaata caacaatgac 3731401 tagttatatg ttaggaatcg atatcggcac gacaagcaca aaagctgtgc tgttcagtga 3731461 aaacggagat gtggtacaga aagaaagcat cggctacccg ctctatacac cggacatctc 3731521 aacagctgaa caaaatccgg aagagatttt tcaggcagtc atccatacaa cagcgagaat 3731581 tacaaaacag catcccgaaa aacggatctc tttcatttcg ttcagcagcg ccatgcacag 3731641 cgtcattgca atcgacgaaa atgacaagcc gctgacgcca tgcattacat gggccgacaa 3731701 cagaagtgaa ggctgggcgc ataagatcaa agaggaattg aacggacatg aggtgtacaa 3731761 acggacggga acaccgattc atccgatggc accgttaagt aaaattgcct ggatcacgaa 3731821 tgaaagaaaa gaaatcgctt ccaaggcaaa aaaatatatc ggcatcaaag aatacatttt 3731881 taaacagctg ttcaatgagt atgtcatcga ttactcattg gcatcagcga caggcatgat 3731941 gaacctgaag ggcttggatt gggacgaaga ggcactgcgc atcgcaggca tcacgccgga 3732001 tcacttatcc aaactcgtgc cgacaaccga gatctttcag cactgcagcc cggaaatagc 3732061 gatccaaatg ggaatcgatc cggaaacgcc ttttgtcatc ggcgccagcg acggcgtgct 3732121 gtccaacctc ggcgtcaacg ccattaaaaa gggtgaaatc gccgtcacca tcggtacaag 3732181 cggtgccatt cggacgatta ttgacaagcc gcaaaccgat gaaaaaggga gaattttttg 3732241 ctatgccttg acggacaagc attgggttat tgggggacct gtgaacaatg ggggcatcgt 3732301 ccttcgctgg atcagagacg agtttgcctc ctccgaaatc gaaacagcga cacggctggg 3732361 cattgatcca tatgacgtgc tgacgaaaat tgcccaacgc gtcagacccg gttctgacgg 3732421 tctgctgttc cacccatatc tcgccggaga acgcgctccg ttgtggaatc cggatgtacg 3732481 cggctcattt ttcggcttga ccatgtcgca taagaaagag catatgatac gcgcggcatt 3732541 ggaaggcgtc atttacaacc tgtacacggt gttcttggcg ttaactgaat gcatggatgg 3732601 cccggtaacc cgcatccaag cgacaggggg ttttgcaagg tcggaggttt ggcgccaaat 3732661 gatgtcggat atcttcgaat cagaggttgt cgttccggaa agctacgaaa gctcatgtct 3732721 cggcgcctgc attttaggcc tgtatgcaac aggaaaaatc gattctttcg acgccgtgtc 3732781 cgatatgatc ggcagcacat acagacatac gccgatcgaa gactcagcca aggaatacag 3732841 aacattaatg ccgattttca tcaatctatc aagattatta gaaaatcaat atacacaaat 3732901 tgcagattat cagaggggct taatcacaca caaatagtac atgacatgaa ggggagggca 3732961 ttaccatgcc gttaatcatc gttgcacttg ggatcttagc attactattt ctgattatgg 3733021 gcttaaaatt aaacacattt atttccctgc tggtcgtatc gttcggcgtg gcactggcac 3733081 tcgggatgcc gttcgataaa gttgtcagct ccatcgaagc aggaataggg gggactcttg 3733141 gccacatcgc gctcatcttc ggactcggtg cgatgctggg caaactgatc gcggattcag 3733201 gaggcgcaca gcgcattgcg atgacgctcg tcaacaaatt cggtgagaaa aatattcaat 3733261 gggccgttgt cattgcctca ttcattattg ggattgcgtt attttttgaa gtaggactgg 3733321 ttctattaat tccgattgtc tttgcgattt caagagaatt gaagatttct attttatttc 3733381 tcggaatccc gatggtcgcg gcactatccg tcacacacgg tttcctgccg ccgcacccgg 3733441 gacctacggc gatcgccggt gagtatggcg caaacattgg agaagtgctg ctgtacggct 3733501 ttatcgttgc tgttccgaca gtgctcattg cagggccgtt atttacaaag ttcgcgaaaa 3733561 aaatcgttcc tgcatcattt gcgaaaaacg gcaatattgc atcactcggc acacaaaaaa 3733621 catttaacct tgaagaaaca cccggctttg gaatcagtgt ctttactgca atgctcccga 3733681 ttatcatcat gtcggtcgcg accattatcg acctgcttca agaaacaatc gggtttgcag 3733741 ataacggagt tttagctttt atcagattga ttggaaacgc atcgactgct atgattattt 3733801 cgttattggt cgcagtctat acaatgggca tcaagcgcaa cattccagtc aaaaccgtga 3733861 tggattcttg ttcaactgcc atttcacaaa tcggcatgat gcttttgatc atcggaggag 3733921 gcggcgcctt caaacaagtg ctgatcaacg gcggtgtcgg cgattacgta gcagacttat 3733981 tcaaaggaac ggcattatcg ccaatcattc tggcatggct catcgcagcg atcctgcgca 3734041 tttctctagg atcggcgact gttgccgcac taagcacaac aggtctggtc attccgttat 3734101 tgggccattc tgatgttaac ctggcgttag tcgtactcgc aacaggagcc ggaagtgtca 3734161 tcgcttcaca cgtcaatgac gccggcttct ggatgttcaa ggaatacttc ggattaagca 3734221 tgaaagaaac attcgccaca tggacattgc tggaaaccat tatttccgtt gctggactgg 3734281 gattcatttt attgttaagt ttagttgtat gaaattaaga aggagctgta acacatgttc 3734341 aattcgattg gtgtcatagg cttaggcgta atgggaagca acatcgcctt aaacatggca 3734401 aataaaggcg aaaacgtcgc tgtctataat tacaccagag atttaacgga ccagcttatc 3734461 caaaagctgg atggacaatc tctcagcccg tattacgagc ttgaggactt tgttcaatcg 3734521 ttagaaaaac caagaaaaat ctttttgatg gtcacagcgg gaaaacccgt agattccgtc 3734581 atccaatcat taaagccttt gcttgaagaa ggcgacgtca tcatggacgg aggaaactcc 3734641 cactatgaag acacagaaag aagatatgac gagctgaagg aaaaagggat cggctacctg 3734701 ggagtcggca tttccggcgg tgaagtcggt gcgttaacag ggccttccat catgccgggc 3734761 ggagatcgcg acgtctatga gaaagccgct cctatcctga cgaaaatcgc agcccaagtc 3734821 ggagatgacc cttgctgtgt ctatatcgga ccaaaagggg cagggcactt tacaaaaatg 3734881 gtgcacaacg gcattgaata tgccgacatg cagctgattg cagaagctta tacgtttcta 3734941 agagaaacgc ttcgtctgcc gctagatgaa attgcatcta tttttgaaac atggaatcaa 3735001 ggtgagctga aaagctattt aatagagatt acagctgaga ttttacgcaa aaaagacgaa 3735061 aaaacaggac agcctctgat cgatgtcatc cttgataaaa ccggccaaaa aggcaccgga 3735121 aaatggacga gcatgcaggc gattgataac ggcatcccgt ccacgatcat cacagagtcc 3735181 ttgttcgccc gctacttgtc atctttaaaa gaagaacgga tggcagctca agatgtatta 3735241 gcaggcccgg aagccgaaga aaaacacttg gataaagaca cttggattga atacgtcaga 3735301 caggctcttt acatggggaa agtatgcgcc tatgcacaag gctttgccca atataagatg 3735361 tcatctgagc tttacggctg gaatctgccg ctcaaagaca tcgccttgat tttccgaggc 3735421 ggctgcatca tccgcgctga tttcctaaac gtgatcagcg aagcattcag tgagcagcca 3735481 aatctggcta acctgctgat cgcgccttat ttcacagata agctccatgc ctatcaaaca 3735541 ggcctgcgaa aagtcgtttg cgagggtatc agcaccggaa tctctttccc atgcttaact 3735601 accgcgctct cttattacga cggctaccgc acagggcgtt ccaatgcgaa cctcttgcag 3735661 gcacagcgcg attactttgg cgctcacacg tacgaacgga ctgatatgga cggcgtcttc 3735721 catacgaatt ggtctgaata acctgtatta aaaacacggt cagtttcaac tgaaccgtgt 3735781 ttttttcttc tatcccaaac aacagaagac ataagttatg ttttaaatat cataaacagt 3735841 gatacaataa tagctagaaa caatccccaa gatcatcatg tgacagcaga ttgctgttcc 3735901 gttctattct gcttttggcc attgtccttt gcccttgacc atggtgtcat aaaatgttca 3735961 aatgccaaaa cggcctggca ttctgattta caaaagtccc tgaaaacctt atctaattga 3736021 gaatcagcct ctcatttatt ataaaagaaa tgcctaaatc ctacctgtca cacctttatt 3736081 aagatgaaaa aaagtaggtt atggcttgac aaaaaatata tattaattaa taattcatat 3736141 ataattagaa ttattattga aagcgattat gctttctaat acatttttag gaggaatata 3736201 cattatgtct ttaatcggta aagaagtact tccattcgaa gcaaaagcat tcaaaaacgg 3736261 tgaattcatc gatgtaacaa acgaagattt gaaaggccaa tggagcgtat tctgcttcta 3736321 cccagcagat ttctctttcg tatgcccaac tgagcttgaa gatcttcaag aacaatatgc 3736381 tgcacttaaa gaattaggtg ttgaagtata ctctgtttct acagatactc acttcgtaca 3736441 caaaggctgg catgacagct ctgaaaaaat cagcaaaatc acttacgcaa tgatcggtga 3736501 cccatctcaa acgatctctc gcaacttcga tgttcttgac gaagaaactg gccttgctga 3736561 ccgcggaaca ttcatcatcg atccagacgg cgttatccaa actgttgaaa tcaatgcagg 3736621 cggtatcggc cgtgacgcaa gcaaccttgt aaacaaagta aaagcagctc aatacgttcg 3736681 tcaaaaccca ggtgaagttt gcccggctaa atgggaagaa ggcggcgaaa ctcttacacc 3736741 tagccttgat ctagtaggta aaatctaagg agtgcattca attggtactt gatgcaaata 3736801 tcaaagcaca attaaatcaa tatatgcagc taattgagaa tgacattgtt ctcaaagtta 3736861 gcgcaggcga agatgacact tctaaggaca tgctggctct cgttgatgag ctggcttcca 3736921 tgtcatcgaa aatttcagtt gaaaaagctg aattaaacag aacgccgagc ttcagtgtca 3736981 atcgtgtcgg agaagacact ggcgtgactt tcgccggtat ccctctgggc cacgaattca 3737041 catcattagt gttggcgttg ctccaagtga gcggcagacc gcctaaggta gaccaaaaag 3737101 tcattgatca ggtgaagaag atcagtggtg aataccactt cgaatcttat atcagcctga 3737161 catgccacaa ctgtcctgat gttgtacaag ctttaaacat gatgagcgtg ctgaacccga 3737221 acattacgca cacgatgatt gacggtgcag catacaaagc agaagttgaa agcaaaaaca 3737281 tcatggcagt gccgaccgtt tacctgaatg gcgaatcctt cggaagcggc cgtatgacgc 3737341 ttgaagaaat tcttgcgaaa atgggcagcg gcacagatgc atctgagttt gctgacaaag 3737401 agccgtttga cgttcttgtg gtcggaggcg gacctgctgg tgcaagtgca gcgatctaca 3737461 ctgcacgtaa aggcatccga actggtgttg tcgctgagcg cttcggcgga caggttctcg 3737521 acaccatgag catcgaaaac ttcatcagcg tcaaagcgac ggaaggaccg aagctagcgg 3737581 caagtcttga agagcatgtg aaggaatatg atattgatgt catgaacctt cagcgtgcga 3737641 aacgccttga gaagaaagat ctgttcgaac ttgaactcga aaacggcgct gtcctgaaaa 3737701 gtaaaacagt gatcctttca acaggtgcac gctggcgcaa tgtcaacgtc cccggtgaac 3737761 aagagttcaa aaacaaaggt gtcgcatact gcccgcactg tgatgggcca ttgtttgaag 3737821 gcaaagacgt tgcggtaatc ggcggcggaa actctggtat cgaagcagcg attgatcttg 3737881 caggtattgt caatcacgtt actgtactag aattcgcgcc ggaactgaaa gcagacgaag 3737941 tcctgcaaaa acgtctctac agcctgccta acgttactgt cgtgaaaaac gcacaaacaa 3738001 aagaaatcac aggtgatcag agtgttaacg gcatcacata tgtagaccgc gaaacaggcg 3738061 aagaaaaaca cgttgaactt caaggtgtat tcgtccaaat cggtctcgtg ccaaacacag 3738121 aatggttaga aggaacggtt gaacgcaacc gcatgggcga aattattgtc gacaaacacg 3738181 gcgcaacaag cgtaccaggc ttatttgctg ccggcgactg cacagacagt gcgtacaacc 3738241 aaattattat ttctatggga tcaggtgcaa ctgccgccct cggcgcgttt gattacctaa 3738301 tccgtaacta atataagaaa tccgctatat tgccagattg gcaggatagc ggatttttct 3738361 ttttctacag aaaaaaaccg aaccaggcac tacggtaaaa gtgctcgatt cgagcgcttc 3738421 ttatagttcc tcaccattcg tttgaatgac atttttatac cactcaaagg agtctttctt 3738481 atatcgtttc atggatccgt ttccttcatt gtcacgatca acatagatca tgccgtagcg 3738541 ttttttcatt tcgccagttg tgaaggagac aatatcaata atgccccacg gcgtgtagcc 3738601 aattaaatca acaccatcgt acgtgaccgc ttttttcaat gcttcaatat gcgattttaa 3738661 atattgaatg cgttccggat catgaacctt gccgtcctcc tccagcgtat ccactgcgcc 3738721 aaagccattt tcaacgatga ataacgggat ttggtatcgg tcataaaaac gatttaacgt 3738781 atatctcaac ccggttggat caatcgccca tccccagtca ctcgaagtga tgtacggatt 3738841 ttcgacacca ttcggcaagc cgccatttac aatatcgcca gtgttatcat ttttcacatc 3738901 gcttttcaca gttgttgaca tgtaatagct gaagcctaag taatcgacgg ttccgtttct 3738961 taaaatctca tcatcgccgt cttcgaatgt gatgttgtag ccttcgcgtt caaattcctt 3739021 caacgcgtag cttggataat aaccgcgaac ctgcacatca gggaagaaat agcgctgcct 3739081 catttcttct tcagccagca tcacatcttc aggattggag gagaaaggat aaatcggcac 3739141 gtgtgatacc atggccccaa tctggaactc tggattgatg tcttttcctt ttgccactgc 3739201 taaggcgctc gccactaatt catggtgcgc cgtttgatac atgacttcct tggcgttttc 3739261 gttttcgcca accacaacac ctgaattcgt ccataggaac agcggattgt tcacatccat 3739321 ttggttgtta atctcgttaa atgtcatcca gtacttcact ttatctttgt aacgggtaaa 3739381 gcaagcctct gcgaagttga cgaagaagtc cacgactttc cggtttctga agccgccata 3739441 ttctcttgcc aggtgcagcg gcatttcaaa gtgagacagg gtaatgaccg gctcgatccc 3739501 atgcttcagc aattcatcaa acacatcatc ataaaactgc aaaccagctt cgttcggttc 3739561 agcctcatcg cctttcggaa aaatccggct ccagccgatg gacgtccgca gacattttaa 3739621 tcccatttcc gcaaacaaag cgatatcttc cttgtatctg tgatagaaat caatggcttc 3739681 atggtttgga taaaattcgt tttcttcaat cgtgtcagtg atttttctcg gcacgccgtg 3739741 cgcacccgct gtcatcacat cgacgacact cggcccttta ccgccttgat tccatccgcc 3739801 ttcaaattgg tgggcagcta aagcaccgcc ccataaaaaa tcctttggca tgtttcccat 3739861 gtttaattcc tcctcagctt acgactgtaa atattttttg atgtaatgca ctttcctcaa 3739921 tgtcttcaat gaaagcttta tcaaactcaa caagcacttc gccttttttg acggtatcgc 3739981 cttcttttac cttcaaggaa aaaggcgtgc cgtcaaatgt caccgtatcc agcccgatgt 3740041 gcgcaagcaa ttcgacgccg gacgctgaac gcaggccaat cgcatgcttt gtaggcgtaa 3740101 ccatgacaac cgtaatgacg ccgggatggt agcatcgatt tcacgatatc cttcgcttta 3740161 ggggtagacc gcttcagcac caatcgaagt ctggtagcgc agcgagaagc cccaatcaca 3740221 ttctcttccc cgcctacggc ctctaaaatg tcttttgcta gtctcgtata atctctcact 3740281 ttccccgaca tttcacccac cccttcgttt tggttacgct ttcattataa ttgtaacggt 3740341 ataatttatc aattccgaaa caaaatattt acgcactaac tatcattgta agcggtttat 3740401 gctataattt tgacaagtga aactaaacga ataaatgagg aatgcgtatg ttaaaatacc 3740461 agcaaatcgc aacggaaatt gaaacatata tagaagaaca ccagcttcag cagggagaca 3740521 aactgccagt cctagaaacc ctcatggccc agtttgaagt cagcaaaagc accatcacaa 3740581 agtccctcga gctattagag caaaaaggcg cgatctttca ggtcagagga agcggcattt 3740641 tcgtcagaaa acataaacga aaaggctata tcagccttct gtcgaatcag ggatttaaaa 3740701 aagatctcga ggatttcaac gtcacctcaa aagtcatcga actggacgtg agaaagccaa 3740761 caccggaagc ggcggaaaac ctgaacatcg gaatggacga ggacatctac tatgtcaaaa 3740821 gggtccgcta catcaacggc cagacccttt gctacgaaga atcctattac accaaatcca 3740881 tcgtgacgta tttaaacaac gaaatcgtct cccactccat cttccattac atccgggaag 3740941 gactggggtt gaagattggt ttttctgatt tgtttctgca cgtgggccag cttaatgagg 3741001 aagaagcgga atatttggga ttagaggctg gactgccgaa gctgtatata gaaagtattt 3741061 ttcacctgac aaatgggcag ccgtttgatt actcgaagat ttcgtataat tatgagcagt 3741121 cgcagtttgt ggtacaggct aatagttttt tattataggg ctcttcacta cggtaggtgg 3741181 tcgacatgta caaaattatc attcctgcca tactagccat ctttgcgctc tggatactct 3741241 tacagatttc actagagatg agcatcgtta agaatccaat gaactacttt atcgtattca 3741301 ttatcttttt cctctttgta aagatggtga aagaaaaaca ataatagttt gggcgatgca 3741361 aacagaaaaa catccttccc ttaacaaact cagccagtca catgcattaa tcttgatgtt 3741421 aatgatatat aggtgcacat aaaaagctac ttcattgtga agtagctccc tttattaaag 3741481 gcccattttg atccatctag ttttagaaaa gcgaaggaca atcgcattta tgataataat 3741541 tgaaactaaa tacaaaataa taaataaaac atcattactc ccaagtgtca tgttatcaga 3741601 ttgcagcact ctttctattc gggggtacat agtgttacct gcctcaaaag gagcaatgaa 3741661 accaaacgtt ttattgctta tagctactaa gataacagaa gtcatccaat aaacgatact 3741721 gacacctata ctaattaata tattaggaca taacacgctt atagttccga taattagaat 3741781 atactgcagt ataactgcag aaaataaaaa aagtaataat gcaaaatgcg aaaaatcatg 3741841 gtacatcaac gatatgatta gcaggcctag cgttataaat gcaaaacatt ctaaaaataa 3741901 aacagctatc tttttataaa agaaagtata gatgttctct ccaattaact tgtaaaagag 3741961 aatatttttg tttgaatact ctctattaat aaagaaagct ataacaaatg aaaataacat 3742021 caaaccaaac tgggtcgcaa cagtatagga gctaaagaaa aacatttcag gtgtaacatt 3742081 actgacttta tcgattccaa caagtaaaaa ataacccagc aaaaataaaa atacaaacat 3742141 tgctcctaaa ataatgataa ctttgttgct aatactcttt ttaaactcta atttcatctc 3742201 aagcccccac tgttttatta ctcatttata tacacttcaa ttaatttatc cactgaatga 3742261 tattgttgaa tttcttggtg attaaatata taataatccc cttctatcgc ctttaaatca 3742321 gacaaatcat gtgtaatgtt gatgataatc ttctcggggt tctcctgaat atacttgttt 3742381 aagaagccat gaatctctat aaccgttttt ttgtctaatg aattcgttat ttcatctaaa 3742441 acaataatat ttttatcctc taataagaaa ctgagcaatt ttaatttttg cttttgtcca 3742501 tcactcaaat ttttgatcag aacttttcca tcaatattat ccagattaag taaatatgcg 3742561 attttatcta tcatttttgc atcaaatttt ttactcaaaa agtgtaataa aaagtcctta 3742621 gaaacatcat taggtatatt cgacgagctg gatattaaag aaacattttg acgaatatct 3742681 ctgccgattc ttttgctatt attcaacaaa aagtctttag caagctgtga tttaccgact 3742741 ccattttttc cgacaacgtg attaattttc ccgctcgaaa aatgcaagtc ggtgtcctga 3742801 agtaacgttt tgcctttcac ttttaaagtg taattcgcta tattcatata catactccta 3742861 ggaaatattt gcataataat aaaatgttct gccttgtgat ttgttactaa tgtctaagct 3742921 tttgaggtac ctctttcgtt tccgatccgg aagcgaaaga aatgttttta gatggctaat 3742981 ttggagatct tttactctag tttacaatat ataatatcca atgtacaact gaattcactg 3743041 caaggccaat ccctataatt tgaatcgtaa gaactaacca atgatttgtc ttaaaacggc 3743101 tatattcatc taagctcaga aaagctaaaa gaattttgta accatcagaa ttcaatattg 3743161 ggattaagtt ccacaataaa gtagacgaga aaagcataaa tgccatagtt aatgcttcac 3743221 tggaaaatgt aaattgattt attaattcta atgtatttat taaaagataa ttgataaaca 3743281 agccaaataa atgaacgatt atcttttcat ttcttgatag catgtaggtt tcattcaatt 3743341 ggacataaaa agcaggaaat acataaaaat tcagtttgaa tcccacttta tcaaagtttt 3743401 tcccgaaaaa ttttaaggaa taaatatgtc ccagttcatg aagcactata ttcattataa 3743461 aataaataac tataattatc cacattttcc agccgtaaaa tactgaggac aatccatttt 3743521 gcaattttat taaatgaata taatttaata tgaacatgag agccgtaaag gataagaaca 3743581 gataaaaaaa ctttggtgat actttctctt tatacatttt aaaacgtaat aattgtttat 3743641 ctgacagaga atttaaacta tttttatagt attctccgct ttttttgtct tttataaata 3743701 cgttgttttg cacaagcact tcatattttt catcttcata ctttaaaatt ttcattatag 3743761 tatttttcca tataaggata gaagtagttt attttttctg cagagttgaa taaggaacca 3743821 caaactccac aaatagagga aaattcataa ggaatgtcaa attcctctat tttgttattt 3743881 tcttttaaaa tattcaaaaa ccatttgaat ccttcttttc taagaataaa taatagcaaa 3743941 ttggaattta acttttccac ggttctttcg aaactttggt tatattcttc ccttagggtt 3744001 attttcgttt caaaaatagc aggggaacaa catggataaa tttctccatc atgatgatat 3744061 acaatgtcat atccgggaca atgtaaggaa tcttcatctt caagactgta aaatttatgt 3744121 atgttttctt gcttaattct agttttagca gcgccaactg atatcattgg aaattttgtt 3744181 atctttacac ctaagattga atcccccaat tcctctaaaa tgtggttgga cattttgtct 3744241 ttggtaactg ccatattaag agaaatatcg atatcagggt atttcctgct atgttctaat 3744301 atgtttttaa tactggaaga cttgacaaat ggagcatggt actcatcata acttatagtc 3744361 agtgctatca catttaaaga attcatatca tgaaagtact cctggacctt tttcttgctc 3744421 aaaccccaaa atccattaga gatcaacgtt atttgttttt catatggttt aatgatttcc 3744481 attagttctt ttaaaaattt ataatctaaa aaaacttccc cacctgtaaa agaaatcact 3744541 tgaatggttt tgttttttgc aaattcagtt actaactctc ttatgtattc tttttccatc 3744601 ctggttgttg aagttggtga actagaaaaa caacaatggt cacaggatgc attacacctt 3744661 gaatctaaat tgattgatac tgttttatta tacatgaaat atcccccaac aaatggtaaa 3744721 ggagagttag actctccttt gtacccctct aattaatgac cacttccaag aatccagcga 3744781 ttttcttttg attttacaaa ataccaaaga tcattcactt ttgctaactt ttgtgattca 3744841 tctaatagac ccttaaattc taagtttttc acagtctcat tgttagtgat ttcctttttc 3744901 atattatccc tcctcctttt ctaatataaa ccaattattc tatatcattc aatacatgtc 3744961 aatatattgt acctaaaaaa tctgaaaaat gtcactattc ttggtatata aagcctatag 3745021 tcctctagcc cctctaagct ataccgaatg aaaggccata gtttgattta aagcttcgta 3745081 atgaaaagta aaacatcaat attgactaca ctagttaagg gatatacaga ttttaagtgg 3745141 aagaaatgag gcaaacaatc ttaccctaaa ccaacctgta ctgaaaagct gttttaagct 3745201 cttgcttacc ccatttggca cctctttctc tcgttttaat tgtctctaaa agcagttatg 3745261 cggtactatc atataaaggt ccaatgttta aaaataatgt catactttta aattcacctt 3745321 atcatgcaca tgctcataaa gaggggttta ttctaaaaag gggatggacg gttttggaaa 3745381 gcaagtacct agatctactc gcacaaaaat acgattgtga agaaaaagtg gtaacagaaa 3745441 tcatcaattt gaaagcgata ttgaacctgc caaaaggcac cgagcatttt gtcagtgatc 3745501 tgcacggaga gtatcaggca ttccagcacg tgttgcgcaa tggttcagga cgagtcaaag 3745561 agaagatacg cgacatcttc agcggtgtca tttacgatag agaaattgat gaattagcag 3745621 cattggtcta ttatccggaa gacaaactga aattaatcaa acatgacttt gatgcgaaag 3745681 aagcgttaaa cgagtggtat aaagaaacga ttcatcgaat gattaagctc gtttcatatt 3745741 gctcctctaa gtatacccgc tccaaattac gcaaagcact gcctgcccaa tttgcttata 3745801 ttacggagga gctgttatac aaaacagaac aagctggcaa caaggagcaa tattactccg 3745861 aaatcattga tcagatcatt gaacttggcc aagccgataa gctgatcacc ggccttgctt 3745921 acagcgttca gcgattggtg gtcgaccatc tgcatgtggt cggcgatatt tatgaccgcg 3745981 gcccgcagcc ggatagaatt atggaagaac tgatcaacta tcattctgtc gatattcagt 3746041 ggggaaatca cgatgtcctt tggatcggcg cctattccgg ttccaaagtg tgcctggcca 3746101 atattatccg catctgtgcc cgctacgaca acctggatat tattgaggac gtgtacggca 3746161 tcaacctgag accgctgctg aacctggccg aaaaatatta tgatgataat ccagcgttcc 3746221 gtccaaaagc agacgaaaac aggccagagg atgagattaa gcaaatcaca aaaatccatc 3746281 aagcgattgc catgatccaa ttcaagcttg agagcccgat tatcaagaga cggccgaact 3746341 ttaatatgga agagcggctg ttattagaga aaatagacta tgacaaaaat gaaatcacgc 3746401 tgaacggaaa aacatatcaa ctggaaaaca cctgctttgc gacgattaat ccggagcagc 3746461 cagatcagct attagaagaa gaagcagaag tcatagacaa gctgctattc tctgtccagc 3746521 attccgaaaa gctgggccgc catatgaatt ttatgatgaa aaaaggcagc ctttatttaa 3746581 aatataacgg caacctgttg attcacggct gtattccagt tgatgaaaac ggcaatatgg 3746641 aaacgatgat gattgaggat aaaccgtatg cgggccgtga gctgctcgat gtatttgaac 3746701 gattcttgcg ggaagccttt gcccacccgg aagaaaccga tgacctggcg acagatatgg 3746761 cttggtattt atggacaggc gaatactcct ccctcttcgg aaaacgcgcc atgacgacat 3746821 ttgagcgcta tttcatcaaa gagaaggaaa cgcataaaga gaagaaaaac ccgtattatt 3746881 atttacgaga agacgaggca acctgccgaa acatcctggc agaattcggc ctcaatccag 3746941 atcacggcca tatcatcaac ggccatacac ctgtaaaaga aatcgaagga gaagacccaa 3747001 tcaaagcaaa cggaaaaatg atcgtcatcg acggcggctt ctccaaagcc taccaatcca 3747061 caacaggcat cgccggctac acgctgctat acaactccta cggcatgcag ctcgtcgccc 3747121 ataaacactt caattccaag gcagaagtcc taagcaccgg aaccgacgtc ttaacggtca 3747181 aacgattagt ggacaaagag cttgagcgga agaaagtgaa ggaaacgaat gtgggtgagg 3747241 aattgttgca ggaagttgcg attttagaga gtttgcggga gtatcggtat atgaagtgag 3747301 gggtgtgggg ttcagggatg gtgatatgct gctcccctaa aagtagatag atgaatttta 3747361 gaaaatctgt ttgccttggg gagttttttc atggctggac aattatacta caaggaagaa 3747421 atactaatac ttatagaatg taattgggta atgattcgga gaaagaggtt gcgaaataat 3747481 atggtattac actgaaacaa ttatcaatgg agaacatgca cgatatagcc gttctatatt 3747541 ctccctctat tatggcactc attagtagac ataaccgtaa aaaaatgcac tcaaaaaaag 3747601 tccattctat ataactctcg ctagggtgga cctttttcaa cattcaaagt actagatttt 3747661 ttctagtgaa agaataagaa aagacataag ttctatttta tcactctgtt ataggttaag 3747721 ttattacggt gtttcattat atactgaatt taaacaccct tgacattatg ggaattttta 3747781 aaacaggtta aaaggaagtt ctataagaac tccctagttt aatattattt ggtcaaaatc 3747841 taaaaccaaa aaatctattt ttatcttcat tgtttctatc taattttgca acaatcatac 3747901 ctttcgactc taattcttga aggtcatcta ataataattc atttttattt attgttacaa 3747961 aatattgtcc gatcctattc tctaacagac ttgaattgat atgttttaat aatgtacctt 3748021 ttacatgagg atcaggatta gaataagatc cgtcatgaat taaaatattc aaactacact 3748081 tatttataca cctgtataaa aaccaagtaa gatcaaatat atttatcttc atatggagtc 3748141 taccatgtga acgttcatcc ggtatagaac aagaaatttt gatccttcct gtagttgatt 3748201 gttttgcgtt acttattcta ttatcatatt caaaatctaa aaatccatgt tggttgtatg 3748261 taacatccat tagattatta aaaagcttct ttaactcact aactatagcg ctataagatt 3748321 gaaactcatc ataatacatt gaattaactc ttaatatttc atgttgaagt tcattaatct 3748381 tatcaaaaat atggtttttt ttatcgtagt cactaattct caatcttact tccgctaact 3748441 ctatttcttt ccttctttgt tcttccatca caatggaaat atcctcaatg aaattgttac 3748501 tctttaaaat tctggcactt gattccagtt gttctgttaa tccttgcttt ttgatattaa 3748561 gtttttttaa atcggcttgt attttaacaa ttttatcttt aaaataactc cctctacttt 3748621 ctaccatgaa attatagaac tcttggactt tattataatt ctgttttact tcctctggaa 3748681 aaaaacctac aatatcttca tagaattttt ctatattttc taattcttta atcttagtta 3748741 cttttttatt taaatcatct atatttcttt gatattgttt acaaatatgt tcattttcaa 3748801 atatttcatt ttgtatttta ttaagttcac ttttaatttc tgagtaccta tttgtatcat 3748861 tattatattt attggcagtc ttagtttgat agataactct attgtaatcc tctatctcat 3748921 ttattaattc atcttcctta acttttaaat cgccaatgtt aatattcatt gattcaatca 3748981 attttatttc actatttaat ttttcaatct tatcccgaaa aacctttatg tttttttctg 3749041 tatgagttgg taaagtaaaa agatagttaa gtaatttata ttgttttaac cctcccctat 3749101 tcggtaaaac tatatcatta aaccctgtct tttcgtctct tataatatac tcccttaacg 3749161 ccgcaaaagt tatatcctct ttctcaccct ttaaaatttc cttttcaata aattttttat 3749221 atacacttat actaactttt ttccattcct ccaaattaaa agttaaagaa gtatcatgta 3749281 atgtataacc atgtttagga gaattaaaag atctagcaag gaatacttga tttccatcaa 3749341 tttccacatt caaaacaata aaaacgtttt tattgagaag aatttcattt gtcgtataaa 3749401 aatttgatat agtcttccct agtaaaaagg agatgcattc aatcatcgtt gacttaccta 3749461 caccattagt ctcttcatga tcttctctct tttcaccaag tattatattt actcctacag 3749521 cattaaattt atactctttc aaaatttctt gggaattgca aacaaaaaga ttttttataa 3749581 tcataacaat cactaactct ccgttctgct aatcatattt tgattaaaag aaactttacc 3749641 taatgaatat aaaaaagtta acgataaata cagtatccgt tcaatattca aatttattat 3749701 aataccttga ctcttagcat aatcaagaaa aagttgatca atatgttttt ccttctctaa 3749761 cagttcataa agtatctttg atgagtataa aatattttct tccacagcat tatatttagt 3749821 taataaaaaa tgattcattt ctggcctctc cgccttttcc ttttttaaag gagaattatt 3749881 cactagagga ataagatcat ttccaatttg aatgttttta aactcatttt ctaataaaac 3749941 ataagagtat ttgagaatat tttcagctgt ttcaatttta agatcaatca ttcttaacac 3750001 ttcttttgtt atcattaaaa atctcacatt cataaatgca ccaacatgtt aaaatcttaa 3750061 tgtatttttt cgttaaagcc tttgaatatg gtaaaactga atgacattct agataaatct 3750121 cattaacaat ttttacaaat atctcatctc cattattata ttgattatga aactctagat 3750181 atttgtctac tatcgtctca gcaatcaatt cctttttatc agcacttaca tacgaagtgg 3750241 aatccattat atggtttatc acaccaaaat actcagaata actatcgaat ttccgtttaa 3750301 aagtttcccc acttttcata tcataaaatt ttttatctaa accaatttga ttatcaaaat 3750361 tactagtaaa tgttttataa ctttctctat actcatgaaa atctataata aagctcttaa 3750421 actcatcttc atcaatttta tcatcgttat cttctatttc tttttcaata aggctctcta 3750481 atctattaat cttataattt aacttccctt cctgtagtct ccttcctcct tggttgtttt 3750541 ttgaccagta tttatattcg gtattccaaa tgtagtatgt tacttctgtc tcgccattat 3750601 ctaaattcac atccaccgaa ataaattctg gagtagcata ctcatccttt ataatggctc 3750661 cacttactaa ttctaagaat ggattttcat ttgtatttgc agtaatatta aatgaagaat 3750721 catgtacatg tcctgccaaa tatagatcaa taaagtaatc atcaaaatgt gcctttattg 3750781 attctctttc ggaagattca atacaaccta acgtatggtg cccaatagct atatttaata 3750841 ccttgccctt atttttctct ttgttcatct tccttattgc tttatataat ttcatctgtg 3750901 cagttaataa cgttccttct tcaccttttt tatctgataa cagacatgta tttattgata 3750961 aaacattata cttctccgat tgatacaaaa aatgcaaatc ttcttccgga tatttaacac 3751021 ccataaaatc ttcataaaaa tcgaaaaatt tcctttgacc ttccactaat atatttgtag 3751081 ctttttgatc tagtttatcc aacatttctg aggggttagg agatttcata atactatcaa 3751141 tcaaaagtgt cctcgtcatg tctctagata tatcgtgatt tcctggcact aagtgtacgt 3751201 tattcttact taatcccata cttttaataa ttccattaag atattcttta acatcttcgt 3751261 tatacacatc acctttgtgt gctatatctc cagttaataa taaaaaatca aaatctgact 3751321 ctcttcttaa aacttctata aaatctaata atttatctct cattacaata gtgtcataat 3751381 tttgaaactg aaaatgcaaa tcagaaattt gtaaaaaacg taccttcaat acaaacatcc 3751441 tctcataagt atatttatcc cctatatatt tctagaaaac tttttattct atatcatctt 3751501 tactctttaa tatattaaga ctctttccac accatcaaat aaattataac ctaaacataa 3751561 ctctttactc attttagtat tgtatttaag tcaaacattg cattggttgc tgaaatatta 3751621 tattcattga attattccat taaatagctt ttagttgaac tttagtcttt ctgtaatggt 3751681 ggagatgctc ttacttatga taaggctccc cacgattaat ccgaaaagcc cgataaatct 3751741 gctccactaa aataagccgc atcaactgat gaggaaatgt catcttcgag aacgatagct 3751801 tctcgtccgc tcgcttcatc accgtgtcac tcaatccgag tgatccgccg atgacgaagg 3751861 tgactttgct ttttccataa gtagccagct tatctattgt atcggctagt tcttcggatg 3751921 ttttcatttt tccttcgatg gcgagggcga tgacgtgggc gtcggggctg attttggata 3751981 ggatgcggtc gccttctttg tcttttatga ttttcatgtc ctggtcgctt aggttttccg 3752041 gcgctttttc gtccgggagt tcgatgatgt cgatttttgc gtaggccgaa agtcgtttgg 3752101 tgtattcttc aatgccttgc ttgaggtatt tttcttttag ttttccgatt gtcacaatat 3752161 tgatattcac aggtcatccc cactttaaaa acaagttatt catatatgtt gtccacaatt 3752221 gtggatatct tttctgtatt ttgtgtaaga tcattcgttc cccactatat atactgcggg 3752281 gtctccacat aattcacagg ctgtggataa actgttagta tgttcgattt ttctgatttc 3752341 gggcggcagc tcgtggtcgt ctatgtacat atccagcacc gtttcgatgt gttcttcaca 3752401 agaataatac gcttgtttca tgttcaaatc ctccgatgtt ttcttccatt tttacaaatg 3752461 ttctcttctc aatataacct atttattcac atgttagtag tgcttcgggc tgagttttat 3752521 ccacaattcg acaaacaagc tgttgatgac tctatttcgc tcgtgtgtta gtttggatgt 3752581 aaccgatgtg tggggaggtc tgcatttgcg ctttagatgg gtttggcttt ttgtgattat 3752641 gttgctgctt gctgagtgtc agccatctta ttgggtgttg gagaaggatc gaatcggtga 3752701 aggcagtcca gacttagaaa tatacgctaa ttatctccaa atgcatgatg acgtgaaagg 3752761 atatcaagtc ttcaccatat cagaaggcaa aaaaatggtc gtcgtgtctc tcggaagcag 3752821 cgagaaagat aagaagcttg aagtgtcgga cgtcaaattc tcatctaaag aaacgattgt 3752881 aactgtggag cgaaaacctg ctcctacggc aaatgagaaa aaccctttta ttttgattgg 3752941 actggacaaa attgaagggg atttaattgt tcaagacgaa acaggagatc gctttgaaga 3753001 aacggattac cagcaataaa gccggcgttc tgagaacgtc cggctttttc ttttacttca 3753061 atgtcccatg cgggtcgatg acgaattttt tggctgcgcc tttgtcgaag tcgctgtagc 3753121 cttttggcgc gtcgtccaga gaaataacgg tggcattgac ggcttttgcg atctgcgctc 3753181 tgccgctcag gatcgctttc atcaaattgc ggttgtatgt catggcgggc gtttgtccgg 3753241 tgacgaaggt gtgggctttg gcccagccga gtccgaagcg gatttttaat gagcctgttt 3753301 tggcgtccgc atcctttgca ccgggatctt cggtcacgta taagcctgga atgccaaggc 3753361 tgcctccgac ctgggtgacg tccatgattg agttcagcac ggcggctggc gcttctcctt 3753421 gattgccgtg cccagatgct tcaaagccga cacagtccac tgcagcatca acggttggtt 3753481 cacctagtat ttgttcaatt tgctcgccga ggcggtcgtg tttttgcacg ttgaccgttt 3753541 cacagccgaa gcttctggcc tgtgccagcc tgtcttcgtt cagatcgccg acaatcacgg 3753601 tagaggcgcc taggagctga gcggagtgtg cagctgccaa gccgacagga cccgctccag 3753661 cgatataaac ggttgaacct gtttgcacgc ccgctgtata agctccatgg aagccggtcg 3753721 gaaaaatgtc ggacagcatg gtcaaatcga gaatcttttc tagcgcctgt tctttatcag 3753781 ggaataccaa aagctgaaaa tcagcgtatg gcaccatgac atattcagac tggccgccga 3753841 cccagccgcc catatcgacg tagccgtaag ccgatcccgg ccggtccgga ttgacattca 3753901 ggcacacatg cgttttctgc gttttgcaca tcacacagcg tccgcaggca atattgaaag 3753961 gaacggatac gatatctcct tttttgataa attcaacatc acgccccgtt tcaatgactt 3754021 ctcccgtaat ttcatgcccg agcaccaagc cttctggcgc cgttgtgcgg cctctgacca 3754081 tatgctggtc gcttccgcaa atgttggttg taatgacttt gagaataacc ccatgctcac 3754141 attttcgatt cacattcgcc ttcgggacgc cgggcccgtc cctcaagatt aactccggat 3754201 aaccgatatc ctccaccgct acagtccctt tgcctttgta cacaaccgct ttgtttcctg 3754261 tcaacgccat tcctcccatt catgtgtttg gactctccgt ccttgaacat gacttcggtt 3754321 cggcatgact ctttcccttt ttcacgactg ttttttctgt attcttacaa caacaaatat 3754381 gccaagaaag catccaataa tggttccgcc gatgtctaag aagtcgactt tacatccatt 3754441 taacaagaac acagtaatgg ccgaaaccag gcagatcata actgccagaa gaataacccg 3754501 atttgtctgc atgtaattcc tcctttggat tcgtttctaa accataccca aaatcctctg 3754561 caaacttcgg ttcaacaaaa aaagagactt cacaccagtc tcttcataaa cagagatcac 3754621 tcaaaaaatt tcctgagaaa taatgtggca acactcgtta ctaacgcaat tgccgtatac 3754681 ataacaaccc aaaatatgaa tgagctattc cccgaagcta acgtaactaa caatatcaag 3754741 ctcgtgataa gaacgatgag cggtgccacc caaaatcttt taaataaaaa atgacccgct 3754801 ataccaaata cacctgcgac gatcggaaaa ccaaaaacga taaataaaac ggcgatggct 3754861 cccatactac cctccttgcc ttaaaacctc ttcatcacct caacatcata cagcttcaaa 3754921 tgactcttcg gcgtcacgac atcctttacc ttcccaatct ctttttcttt cattttcttt 3754981 ccggttttca ggctgtactg ttcaatgtag gcaggcttgt gatacgtgta tgtgaagaaa 3755041 tagaggctgc tgcctttttg ggtgatttct ttgaattcgg ctttcatttt gtccggggaa 3755101 agggtgaaga cgatgcttgt ttttcctgtc ttggcatcga ttttgtgtac ctttccgaag 3755161 ccgtcaatga aatacaggtt cccgtcataa gggaaaaagc tgtttttaaa gctgaagggc 3755221 atggagctgt atatcgtttg ttcgtcgttt ttgtattcgg cgatatcgtg cagctctact 3755281 tcgccgcttt ttttgttgat cttgaccatt tgatagagat cgtgggcttt ttggccgcga 3755341 accataacat acacagcttg gtcgtccacg gcaagttggg attcgactga ggctccttcc 3755401 cggtactgcc attccgttat gctgagatag gtaagcttct tctgatctgc ttgaatctga 3755461 aggagctgat agccttttcc gtcatctgtc gggacgagtg cgtaaatggc gccatcatgg 3755521 aaaccggagg ctcggatgta gtaggggatg acgtcttttt tccactctcc gtccatttgg 3755581 cggtacagct ctgagcggta tccgtctccc tttttgtcgt agccggagtt gtataaggtg 3755641 taaaagccgt ccgtgttttg cagaaagccc gcgctgtcgc ctgtgtgctg ataggttctt 3755701 ttatgggagc gcaggccgtt tttgatcgta taaatcgtgt ttttgtcctc cagcatcacg 3755761 ctgtcaccgt gaacctttgc tgagcccagc tcaaggccct tcatctgaaa ggaagacagc 3755821 gtcccgtcat ggctgataaa cagggcgtag cttttcccgc cgccaaatgc atcttgatcc 3755881 gcagaggatg agaaatacag caggacttct ttgtcatcca ggaaatcggg atttctgaga 3755941 tcctgctgac tcacggtttt atggcttttg agaggagaaa tgaagacaaa tagtgcgatt 3756001 cctgcgagaa tcagcatggc gatggtaatc atccactttt tcatagcctt ctccttagta 3756061 aatggtcata atggttgtcg tataagaaga actagtgatg tcgcgcggat acacgcctaa 3756121 gcctccgttg ctgtctatat caatccctgc tttcagcaaa aaggcagacc ataggagctt 3756181 tgaacagttt ttggcgccgt catggccggt atttctgtta ttgacgaagt taaatgagta 3756241 tgggtcgccg acttttgata ccgcccagtc ggcagcagct gttttttgag atgaggatac 3756301 gctgacggtt tgcacaatgg agttgtcttc cacgtctctg gcattatacg cgatctgcct 3756361 gacgccgtcg ctcgggacag attcaacaat tttgtcagcg gcggagtaca tgccgacatg 3756421 gccgtgattg tagtaggctg tgtaggagtt cgtgtaatag atattgcctt tcgcgcttgt 3756481 cgggagtttt ttcgtgccgg acgagccgcc catgatagac atgccgcttt ccttggcgag 3756541 ccggtccccc tctgctttat cagccgtgat ctccttatag aactgtttta ggataacgtc 3756601 ctgctttacg tgctgctgtt tggcaatctg gctggcagat ttcatgattt cttccggtgt 3756661 cgtgcctggc tgcagtgcgg cgatttcttc agcataattt gtggtcttta cggctttggc 3756721 gggagtaaca aacaggccgc cgcacattgt gagcgctacc aaaaacatcg acactcgttt 3756781 cttcaacttc attacatctc ctcttttctt gtgagtgtag gaaaggtaat ttcctcaccc 3756841 acattatatt aggaaaataa ggaaagtaac taggttattt acagaatttt tagaaatcgt 3756901 ttacagaaaa aggcctttat caggcccttt tcgttaaagc ttcttgctca tcactacgtc 3756961 tgtttcttga aatccggttt gctcatatag ctttcgagcc gtctgattat gggcaaagac 3757021 atgaagggac agcttgcgga ttcccatact gcgtgccgct tgatctaatg ccgccaatgc 3757081 ttgctttgcg tagccctttc cccgatacgg ttcatataac ccgaaatcat aaataaacgc 3757141 ttcctgctgc ggatgctccg gttcagcatg tatccagagc cagccaacga tatccttttc 3757201 attcagcttg aggctccaca aatggtgatg gggtgtttcg agccctctcg gaagcagatc 3757261 agtaaacacc tgcttagaca aaagctgggc atcttcaggc agccatgttc ccgcttttac 3757321 cttttcttcc gcgtaatgct ttgttgtgta cgtgagataa gaccgaaatt cttctgtctg 3757381 cataggggtt agcataattg tcatatcatc tctccttcat atattgacta gaggatttta 3757441 cataaaatag aaagaggtgt tactatcaga ataagcaact gagattgata agtcactaga 3757501 gaaaggagtt tcacatgaat aagatcgcac ccgcagaaat cgctagcatg ctcaacgatt 3757561 ggtaccttgc catcaagaaa catgaagttg aagaatcctc ccgtttattt gaagaagtga 3757621 agcctttatt ggatgacatg gaagaggatc aggaggtgct tgcctacttc tccttattgg 3757681 aactgcgcca caaggttttg cttcacgagg cgagaggaca gggctttcag catgaggagc 3757741 cttctcatat gaatgctacg tctgacatgc tgaaatatta cttttttctg tttgaaggca 3757801 tgtatgaggc ctataaaaat aattatgaca ttgccattgg gctgtataaa gatgcagagc 3757861 agtatctcga caacattccc gatccgattg aaaaagccga atttcacctg aaggtcggta 3757921 agctctatta taagctggga caaaatattg tgtccctcaa tcatacacgg caagcagtca 3757981 aaacattcag agaagagaca gattataaaa agaagctggc ttcagccctg attaccatgt 3758041 caggcaattt tacagagatg agccagtttg aagaagctga ggcttatttg gacgaagcaa 3758101 ttcggatcac gagtgaatta gaggatcatt tttttgaagc ccagcttttg cataacttcg 3758161 gccttctaca tgcgcaaagc ggcaaatcag aagaagcggt ttcgaaatta gaggaggctc 3758221 tacagaacga tgagtatgcc cgctccgcct attattatca ttctgcctac ttgctgatac 3758281 gagagctgtt taagatcaaa aagaaagaac aggccttatc ttattaccaa gacgtgaagg 3758341 aaaaattgac tgctgagccg aatagaatat gtgaggcaaa aatagacatt ttatatgcca 3758401 tttatgcaga agggggtcat gcggaaacgt ttcacttatg caaacaacat atggatgact 3758461 tgttgtccga gaaagagtat gacagtgtaa gagaactttc cattttggct ggcgaacggt 3758521 atagggaact tgagctttac aaagaagctg cccacttttt ttatgaagca ttacagattg 3758581 aagaactgat taaacgaacg gaggttatat aaatgaaaag atttctgatt ggcgcaggcg 3758641 tcgcagcggt gattttatca ggttggttta ttgcggacca tcaaacccac tcacaggaaa 3758701 tgaaagtcgc tgagaaaatg attggataaa tgaaaaaccc ccgcgggatg cgggggttca 3758761 atttaacgaa agaatcctaa aacggtttgt agttttagga ttctttcatc ttttcagcgt 3758821 gattgaaaac ccttgaagtc taggaagaac gagcattgga gcgcagcgaa tgtttggaat 3758881 tcgtgagcac cgaagcgcag gcctgacaac gaatgcgagg gtttgtcgac acgctgaaac 3758941 ccccgcgggt gcgggggttt tcttattaca gcagcttctt ccctaacagg gattctacga 3759001 gctctactgc tgttttgccc gttttgtttt tgtgatcaag gatcgggtta acctcaacga 3759061 attcggctga ggtaatgatg cctgcgtcat acagcatttc catagccaaa tggctctccc 3759121 ggtagctgat gccgccgacg acaggggttc cgacacccgg tgcgtcgttc ggatcaagtc 3759181 cgtccagatc aaggctcaga tggacgccat cacatgctga taaataatca agggtttctt 3759241 caatgacctt tgtcatgcca agacgatcga tttcgtgcat tgtgtacacc ttcatgccgc 3759301 tttccttaat gtacttgcgc tccccttcat caagtgaccg ggcgccaatg atgacgacgt 3759361 tttccggttt gattttaggc gcgtagcctt caaggttaac cagtgactcg tggccaatgc 3759421 ctaggctgac cgcgagcggc atgccgtgaa tattgcccga tggtgaagtt tcaagtgtat 3759481 tcaaatcgcc gtgcgcgtca taccagatga cgccgagatt atcgtaatgc ttcgctgtgc 3759541 ctgcaagcgt gccgatcgca atactgtggt caccgcccag gacaagcggg aattttttct 3759601 cttcaatgac tttgttgacc ttttgcgcga gtttttcatt tcccgccaaa acggaattca 3759661 ggtttttcag ttcctcgtca tttttgattt tttcgcgatt gatcggaatg tcaccgagat 3759721 cttcaaccgt ataccccatg tctgacagcc tctcgatcag atgagcgtac cggatggcac 3759781 tcgggcccat atccactccg cgtcgtgctt gtcctaaatc cattggcatt ccaataaccg 3759841 aaatcgtttt atccatctgt gattccacct caacatttaa gataatgtcc tatgcgggtt 3759901 ataacaaaga tgacttgcgg acaacgtttt taaagctcta gctgacgatt tgcctgctgg 3759961 cgttttttaa tgacgacatg ataaatgatg tagcaaatga tcataaacgg tacgccgcaa 3760021 tacagcgcga tacgctgctc cggatcaaat gcaagactga tgagcacgac cgtatttaac 3760081 gttaggccga tcagcggaag caccgggtac agcggtgttt taaatttcaa atcttctatc 3760141 ttcccgccct cacggatata tttgcgtctg aacatgattt gggaaagcga gatcgtaatc 3760201 cagccgacct gcgcgctcat gcccgccaaa gataacagta ccatatatac ggtttcagcc 3760261 tgcgcaaact ttgtcagaag tgataggcag gccacagcca tcgttacgat taacgagtac 3760321 atcggtacac cgcgctgatt tgttttgcca agcgctttga aggcttgtcc ttcattcgcc 3760381 atcgcgtaca gaatacgtgt tgatgcgtat aaacctgagt tcgcaacaga taacagtgcg 3760441 attaaaataa caaagttcat gatatcagct gcatatggga ttccgatttg ctcaaatacg 3760501 gcaacaaatg gactttccac gacacccgcc tgtttccacg gaatcatgcc ggcaatgaca 3760561 atgattgaaa gcacaaagaa cacaagcgtt ctccatactg tctgtttgat ggaccgcgga 3760621 atcgtttttt cagggtcttc actttctccg gctgcaaccc cgatcagctc agtcccctga 3760681 aacgcaaagt tcacagtaat catcgtaatc agcattgcct ttatgccgtt cggaaataac 3760741 ccgtcttcat aaaaatgtgt caaaaacggc gcctgctctc cgcccttcag atcaatcagg 3760801 ccaaacatgg cagctccgcc gagaataata aataaaagga taatcaaaat tttaatgcct 3760861 gagaaccaga attcagattc cgcaaaggct tttgtggtga tcgcatttaa aataaacatc 3760921 agtgccgcaa agaccagaca ccagatccac acgtctatat gcggaaacca gcgttgcatc 3760981 agctgccccg ctgataaaaa ttcaatggcg catgtaaccg cccagccgag ccagtacagc 3761041 cagccgaacg caaacccgaa ggccgggctg ataaatttcg tggcataggt ctggaaggac 3761101 cccgacacag gaaaggcgac tgccagctct cctaagcaga gcatggtcaa aaacatgata 3761161 aagccgccca ctaaatagga cagaaccgcg ccgagcggtc ccgcttggtt aatggtaaac 3761221 ccggttccaa ggaagaaacc ggttccgatc actccgccca atgaaatcat gaacaaatgg 3761281 cgtgatttca ttgtccgctg gagctgattt ccgttatctt ggtttgtatt cacattctgc 3761341 accccttcag caacttgtat tggatctaag ctggaacatc tgcatggtgc tatcccagtt 3761401 tgctgtccaa agagtctcta tctatttaat ataaaattca cttcttctca taaagataca 3761461 ttatactaaa atactgtagc tgagcaaata gggagtgctg atttttctgt tgtaaattta 3761521 tacaaacgaa gtgaatatcc cgccatggtg cggatttatg cgtttcgcag cacgtgctta 3761581 attttctcta tcgcccaatc caagtcctct ttggaaatga ttaatggcgg tgcaaaacga 3761641 atgactgtat catgcgtttc cttgcataaa agtccctctt ccttcaaacg ctcacaatac 3761701 ggacgtgccg cttcagtcaa ttccacaccg ataaacagcc ctctgccgcg gacttcttta 3761761 atgacagggc tgtcaatact ctcaagctcg cttttaaagt attcaccaag ttcaagagaa 3761821 cgatccgcca gcttttcatc ctccagcact tctaatgaag cgatagacac tgcacatgca 3761881 agcgggtttc caccaaatgt tgagccgtgt gagccagggt taaacacgcc taggatctcg 3761941 cggtccgccg caatgcaaga gatcgggaac acaccgccgc caagcgcttt gcccaagata 3762001 tacatatccg gaacaatgcc gtcccagtca caggcaaacg tcttgcctgt acgtccgaga 3762061 cccgtctgaa tttcatccgc aataaacaag acattctctt ccttacaaat cgccgccgct 3762121 tcctgtaaaa atccttcagg cggaatcaca atgcccgctt cgccttgaat cggttcaaac 3762181 aagaatgccg ctgtattcgg cgtaatggcc tgtcgaagcg cttccacatc gccgtaagga 3762241 atgagtttga ttcctggaag catcgggccg aatcctcgtt tatattcctc ttcagaagaa 3762301 agagataccg ccagcatcgt gcggccgtgg aagttcccga cacatgcgat aatttccgct 3762361 tgattgtcag ctacgccctt cacttcatac gcccagcgtc tcgccgcttt caccgcggat 3762421 tcaaccgctt cggctcctgt attcatcggc agaatcatct ctttgcctgt cagtttagct 3762481 gttttttcgt aaaacggccc aagctgatcg ttatgaaacg cgcgtgacgt gagggtgatt 3762541 ttatcagcct gatcctttaa tgcctgaatg attttcgggt gtctgtgccc ctggtttacc 3762601 gcagagtaag cactcagcat atccatatat tcattgcctt ccgggtcctt tacccaagca 3762661 cccagcgctt cagaaataac aatcgggagc gggtgataat tgttggctcc gtaatgagac 3762721 gtctgatcaa taatttcttt ggatttagat aaagctgtca tatttgaatt cccccttgtt 3762781 ttctgtttca acatgttatc ctgctttccc tttatataaa tgcaagttct gtgccaaatc 3762841 aagaattcgt gtgttttcta caattttcga ggacaaggtg caaaaacatt ctgatatttc 3762901 gagcgaaaat ttcagcaagt gcaaaattct tttgcatatc ctctccgttt ttttataaaa 3762961 tagaagcaat attaagaaaa taattgaggg aggttcatac agtggtcaaa gacagcgaat 3763021 tcctcacatt ggtttttcag agtattttag atgaaatcga tgttggcctg cacgtggtag 3763081 acgagcatgg aaacacaatc gtttataaca ataaaatgat gcagattgaa gatatggaga 3763141 agcatgacgt cttgaataaa aacctgatgg atgtgtttat gttttcaaag cagcaggaca 3763201 gcacactggt acaggctctt caggaaggca agacgattaa aaacgtcaaa cagagctatt 3763261 tcaataataa aggccaggaa attacgacga tcaatcatac atatcccatc gtccaagacg 3763321 gcaaaatcag gggcgccgtt gaaattgcca aggatgtgac aaagctggaa cggctgatca 3763381 gggagaatat gaacaaaaaa ggcagcacaa cctatacgtt tgacagtatt ctcggcacca 3763441 gtccggccat tcaagacgtc atcgaaaacg ccaagcgggc aacccgtacg tcatcatctg 3763501 tccttctagc aggcgaaacc ggcacgggaa aagaactgtt cgcgcaaagt atccataatg 3763561 gaagcgatcg ttctggcggc ccgtttattt cgcaaaactg cgcggcactg ccagacagcc 3763621 ttgtggaaag cattttgttt gggacgaaaa aaggcgcgtt taccggcgct gtcgaccagc 3763681 ccggcctgtt tgaacaagcc cacggcggca cactgctgtt agatgaaatc aactcgctga 3763741 atctcagcct tcaggcgaag ctgctgcgcg cccttcaaga acggaaaatc aggcgcatcg 3763801 gttcaacaaa ggatacaccg attgacgtac gtattattgc cacgatgaat gaagacccaa 3763861 ttgatgcaat tgcaggcgaa cgaatgcgga aggacttgta ttacaggctg agtgtcgtca 3763921 cactgatcat cccgccgctt cgggaacgaa aagaagacat tttgcttctc gcgtcggagt 3763981 tcatccagaa aaacaaccat ctgttccaaa tgaatgttga acacatcagc gatgacgtga 3764041 agcaattttt cctttcttat gactggccgg gaaatattcg cgagcttgag catatgatcg 3764101 aaggcgcaat gaatttcatg acggacgagc aaacgattac ggcttcccat ctgccctatc 3764161 aataccgcat gaaaatcaag ccggctgaca tcccagagcc ggaaacacca agacaccagc 3764221 cagccgcgga cttaaaagaa aaaatggaaa gcttcgaaaa atatgtgata gagaacgtgt 3764281 taagaaaaca cggccataac atctcgaaag ctgctcagga gcttggcatc agcagacaaa 3764341 gcctccaata tcggctgaag aaattttctc actcgtctaa cgaataatcc ggagcaggaa 3764401 gcctgatcag aaaaacagtg cctctgccga tttcactttt cacttcaatc gtcccattgt 3764461 gattgtcgat aatcgatttc gttatggcaa ggcctaatcc cgaacctcca tatttccggg 3764521 agcgggatgg gtctgccttg taaaaccggt caaacactaa aaaacgtcac ttcttatgca 3764581 ttgaagaaag aaaatggcac ctatgtgtat cacagccagc aaccacacgg tacaaaccat 3764641 taaagtccat gcaaataacg gaagtatttg cagctaactg ccatttgctg tttcacgtgt 3764701 aacatccatc ttgtattttt cttcatattc gatatatcct ttttcaactg aacgggcgtg 3764761 acccctgttc agtttttttt gcatatcaaa acagcctggc aacgatgcca gactgctttt 3764821 attaactgcc taattggtct gcggaggaca gcttgatatc aacagatttt tcttttccgc 3764881 cgcgataaaa cttcaccttc acccggtcac cgactttttt ctgataaagc cgttttcgca 3764941 ggtcaacaat atcatttact ttgtatccgt caaattccgt gatgacatcc agttccttca 3765001 gccccgcttt tccggcaggt gaaaaggcgt ctacacccat cacaaccgct ccattggtga 3765061 cgttcttagg aagctttaat gtttcatccc aatgatagct tgcgatgtca cttagcgatt 3765121 tcatctcaat gccaaggaac gggcgtttga cctttccgta tctctctaaa tcctctatca 3765181 cagggatcac gagcttagac ggaatggaca ggccaatccc ttcaaccgct gactcggcaa 3765241 ttttcattga attgatgcca atgaccttcc catccatatt taacaaagcg ccgccgctgt 3765301 tcccagggtt aatggccgca tctgtttgca ggacttcagc gttccagtca ggctgtccat 3765361 caccgtttga atctactggg atcgccctct ccgtacccga gatgacgcct tgtgtgacag 3765421 agcctgcaaa ctcaaggcct aacgggttcc cgatcgcaat aaccggctcc ccagacttca 3765481 ctttatctga atttccgaaa tcagcgactg ctttaatctt atcgcttttc acccgtaaaa 3765541 cggcaaggtc catcagctgg tcgctgccga caagatcagc tgatacacgt gagccgtctt 3765601 tcaagctgat ttcaatttgg gaagcgcctt cgatgacatg atggttggtc acgacataag 3765661 cggaatggtc atttttctta tagatgacgc cagagccgct cccagcctcg ccgctctctc 3765721 cccaaatatc tgatttttgg atgttcacaa caccgacaac ggcgggcgac atattgctga 3765781 caatcttggt gacggcattg ttgacactga cattcaccgt cctgattgat tcccggccat 3765841 tgttgttttg ctgctgatct aaggcgcctg tatccagccc ttcatttgaa aggtacggca 3765901 tgataaacgc cattaatacg gcaccgacaa tcacgccaat cagactcgaa agaaaatatc 3765961 cttttttgct tctctttggc tgttcaggag tagtatgttc ttcctcacgt tcgtaatcca 3766021 ccatattcca tcctttccaa gaacgttaat atggttatat tgtgggttag aaactcctag 3766081 aatagtcatg atttacatag aaaaattata cagcgcaaag cggagtggcc ttcttcggat 3766141 cggtgtcgta taagtcaaat gtctcacccg tcacaaatcc tttagaagcc aatgtctgct 3766201 gcacagacat tcttgccagc tccttcatgt tgttgtcctg gctcaaatgc gccaggtaaa 3766261 tacgagacgt ctcatcgcca atgacatccg tcatcgccaa ggcagcatct tcatttgaca 3766321 cgtgcccgac gtcacttaaa atccgccgct taatgctcca tgggtatctt cccatttgca 3766381 gcataccgac atcgtgattg ctttcaaaca caaatacatt cgctgaacgg ataatgcctt 3766441 tcatccggtc gctgacatat cccgtatctg tcattaacgc gagctttcgg ccgctataat 3766501 ggaatacata aaacatcggt tccgccgcat cgtgggaaac gccaaacgat tcaacatcaa 3766561 gtccgccgaa cgacttcacc gtctccattg gaaatacaaa cttttgatcg gtgtcaattt 3766621 tgccgatttg attctccatc gctttccaag tcttctcatt cgcatagatc ggaagcttgt 3766681 actttctggc gacgacacca aggcccttaa tatggtcact atgctcatgc gtcacaaaaa 3766741 tgccgtctac atcatccagc ttacgcccga tctgcgccat cagcccatcc atggcttttc 3766801 cgctcaaacc ggcgtccact aaaaatgcgt gatcctctgt ttcgaggtaa aacgcatttc 3766861 ccgtactccc gctcgcaagt acgctaaatt gcaagctcat gtttgtctca ctccattatt 3766921 ttcattgatc tgtatctaaa atcgtactct ccaaagcatt cacagtaaaa tactcttgta 3766981 ctgtcttttt ctcaccgttc acttttttct cgtactcgac cgtaattctc cataccggcg 3767041 ccagcacctg cgtacttgtc agcggatatt gtgctacata gccgaattta cagctcttca 3767101 cagtgctgta ttcttttaat tgattttgat agtacaatag ctcaaccgca tccatttcag 3767161 taattaagct ttctttctgg atttgcttga aggtctcaag cgtagtctgg tcgtatgaca 3767221 caacctcgtt tttaccgttt aagtgcagca ccacttgccc gatcatatta gagggattgt 3767281 cggtcttttg gtaaatataa tgaccttcgt acgtttggaa gaaaataatt tctttcttcg 3767341 atttatcaac cttccaaagc ttatattttt cgccatcttg aattttcgaa gaaacaagtg 3767401 cctgagcatc gtcctcgata tccttctttg atagtgcgat tggatttgca aacttcattt 3767461 tcaggctcgt tactttatga tcatcactag gcatgtccat caaaggcttt tgatccttca 3767521 gcgcctcaat ttcctccttg gagaaagact tttgatttgc cgtgatccga tagccttctg 3767581 ttgcttcctt attcaagcct tcatacgtga tatgatcggc cttcatgtca tgctcgacat 3767641 catttttaat gacttcatat tctttgccgg tagcctgcca tttttgaaaa aactgatagc 3767701 ctaagaaaat atctaaaatg aggaaggcaa cgatgaagat tgattttgtc ttattccact 3767761 ccactgttag ccccctcctt cctcaataaa tcctttgtaa tcggcacaat ttttccattt 3767821 actttcatcg cccaaaccgg ttccagttca acgagaggat catcgttggt tgatgttgat 3767881 accaattgat aagcaaggaa gatctgatca attttgtccg tatcataagc ggtttgtttc 3767941 gaaagcagca tcttcacttc gctgccgccc atgagctctg tttcacttgt tttaatcgga 3768001 ttcgttccga gactgtaatt cggccgctta tagctgagaa tatcatcatt cgcccattgc 3768061 accgtaatcg ccgatgtcgc cccgaaaggt ttggcggtgc tgttaatgac cgggatctga 3768121 tccataaaaa tatagaagct caactgctgg ctgtcattga tattgaaaaa ttgatagtga 3768181 tccgtccagc ttccggtatc ctcaaggtat ttttggctct ttttgattaa ttcacctgtt 3768241 tgataggatg tgctctgcac caaattgcgc tgctgaaatt gcacctgtct ctggcttaga 3768301 ttcacatcta accggctgat cccatctgtc agcacatttc tgttggtgta attcgaatct 3768361 tctcttacaa tgctcggatc actaaacaaa gcctgcttaa aggtatttgt tttaatcgat 3768421 tctgtgacaa attctttttt gtccatcgta agcggtttgt tcggcagcaa gaactctttc 3768481 tttgagccaa tggagaacaa actgaacgcc ggcatatttg attgcctgtt tttcaagtcg 3768541 ttcataatgt tccggtagtt tgctgattca accgtcactt caagaatgag ctgcttgctg 3768601 tatgacacca aatagatttt cttgttcgct tttgtttcat tgaacgggat cagaatatgg 3768661 tcaaacgaac tgtattcaaa cgactgatta gaccatttaa acagcgtttg gaaaatatca 3768721 atcgggatcg tatcgctgaa ttgcaagtca agcttggctt cagaaccgcc tattccataa 3768781 aaccagcttt tgaatccagc cttgtcatac tgatccgaaa tatctttaat tcctttcaca 3768841 tcccaatgcg gcaagtcaga ccaaatttct tcatagaggg cattgtcatc cactttgtaa 3768901 tgagcgccgt catcatggat aaacatgtcc cttggcctta ccgtttcaga cagcttttgg 3768961 gtggtttttt cgattttatg tttcacacga acagtagact ctgttgagga tgagccttca 3769021 gaaaagtttg gctggaacgt ccatatcccc catgtaaaaa caagactgat gacgacgagt 3769081 accgtaagta atatcgtttt tatattttca cgcttcatcc caatcatcct cttgttcctc 3769141 tttatatgga agagtaaatg taatcgtcgt gccttttcct tctatgctgt ccgcccaaat 3769201 atctccaccg tgcgcctgta ccatttcctt ggcaatcgcc aatcccagac cggtgccgcc 3769261 aagctttctc gttctcgctt tatccaccct gtagaagcgg tcaaagactt tttcgacatc 3769321 ttttttcgga atgccgatcc cttcatcctt cacgctgata tagagaagtt cttcctcttc 3769381 attgacatca atcgagaacg tgacatgtcc gccttccggt gaatatttta aagcgttaga 3769441 aataatatta tcgagcacct gcgttatttt atcctggtca atctcgacat acagatctct 3769501 gtccggcaga ttgcggataa actccacatg ctgctctttt gtcatttcaa aacggtcaat 3769561 aataagtgac ataaaccgga caatctgaat ccattcccgg ttaaattgat aatctttact 3769621 gtcaaatttc gacagctgaa gcagatcatt gacaagccgg atcatacgct ctgtttcatt 3769681 ttgcgtcacc attaagaagc gcggagcaat gtctttattt tcccacgcgc cttcagctaa 3769741 cgcttctaaa tagctgcgca ttgtcgtaag cggcgtccgc agctcatgtg atacattcgc 3769801 aacgaattct ctgcgttcct gatccatttt ctcttgttcg gttacatcgt aaatgacagc 3769861 gattaaacca tcaattttgc cgtgttccct ttgaatcaca gagaaattca cgcgaagcac 3769921 cgttaattca tcatcgcgct caatttcaag cagcatagaa tcctgctgtt ccactaaatc 3769981 ttcaaaagta taattctctt gaagccccag caaactcgta atcggcattt ctaaggctgt 3770041 ttcacgtgaa acgttcaaca gttccagcgc cgggctgttt aagagaataa tcgctccgtt 3770101 tcggtttgtg gcgataacgc cgtctgtcat ataagcaatg acagaggcta gctttctgcg 3770161 ttctccttca gtcatcgcct gggcatcttc aagctctctc gttaagtggt taaacgttgt 3770221 ggccagctgc ccaatttcat catgtccata ctttttaacc ttcctcgaga aattcccttt 3770281 cgcaagctcc atcgcctgct ttcgcatatc tgaaagcggg tgggtaatgg ttcttgccag 3770341 aaaaataccg agaagagccg tcaaaacaag tgccaaacct gtgccggacg ccagtatcgt 3770401 gttgatcgtc ttcatttgat taaagacatc ttccatactc gcgacaacgt agatcgcgcc 3770461 cacaacctct tggttttcag tcatgacggg cttcgcggaa ataagaactc tgattttgct 3770521 tttcgggtca taatattttc ttaaatacga ctgtttggta gaaaagattc ttttgaaaat 3770581 cagatcggtc gtttgtttcc cagccacttc ctcaccgtac ggctttgaag aaccgaccac 3770641 ttcatagctt ttatctacaa agctaatttc ccgaacctca tcacttttcg tgaagtcatt 3770701 caaaatacgg ctgacgtcat cctttatgac ggtactgtcg ttatcgctct tatattcttg 3770761 ttcgatataa taagaaaggt tgtcgattcg ctgattcagc gattgttcat aagagctgat 3770821 cagcgacttc tctacctgat tgacaaaata cacaccaatg atttgcatgg caatgataat 3770881 caaaagcaca taaatcaagg taatcttaaa ttggatcgac cgaaaaaaac caaccttatt 3770941 catatgggca ttagtcctgt tctgggtttc tcaagtaata acctacacca cggcgtgtga 3771001 cgatccaatt tggatggctc gggttgtcct cgattttttc acgaagccgg cggactgtta 3771061 cgtcaaccgt tctgacatcg ccgaagtaat catagcccca aacggtttga agcaaatgtt 3771121 cacgggtcat cacttgtccg atatgttttg ctaaataatg aagcaattcg aactcacgat 3771181 gagtcaattc gattgtttcg tctcgttttg atacaacgta cgcgtcaggg aagatgacga 3771241 gagagccgat atgaatctcg ttagaggaag gctcttcctc cgcaggcgct gttgtcagct 3771301 ggcggcgcag gttcgctttt acacgcgcca agagctcgcg tgtgctgaat ggttttgtga 3771361 catagtcatc agcaccgatt tcaagcccga taaccttgtc aatttctgaa tccttagccg 3771421 tcagcataat gattggcata tcgtatttct ttctgacttc gcggcatact tcaacgccgt 3771481 ctttatttgg gagcataata tctaaaagaa ttaaatcagg ctgaagctct tctaccattt 3771541 caacggcttc gtttccgtcg tgggcacagt gcacttcata gccttctttt cttaagttaa 3771601 attccaatat atctgcaatc ggtttttcat catctactac aaggatcttt ttatccatca 3771661 ttttgatttt cctcctgccg aatgacttca tttcatctat ataacattcg tttcatcact 3771721 tatggcccat gtaaagaatg ggtccttgtc tattataacg gtttaaggtc aaaagataaa 3771781 aaaaataaag gtttagaaaa aaaacacatg tttcaccttt atcgccagtt gtttatctat 3771841 tgtcatgctg gtcaactttt tttaaaaaag ataactttat tgaaacctcc cctcaccgga 3771901 gtgcgtcttt atcaatgacg tcttcttctt tgaaccggcc gcagggccgg ttctcccttt 3771961 ttcttctatt ataacactcc tcatgtttgc ctttttccta aaagaaaaaa cgcacctacg 3772021 attgcagatg cgtttggtaa gtggctcggg acggaatcga accgccgaca cacggatttt 3772081 cagtccgttg ctctaccaac tgagctaccg agccaaatgt tttatttttc tctactaagt 3772141 aaagtaaaat ggcggtccgg acgggactcg aacccgcgac ctcctgcgtg acaggcaggc 3772201 attctaacca actgaactac cggaccttac agtaattgcc cggagagctg tcgtgtcagc 3772261 tctcacagac aaataaggaa tttagcaata acgctaaagt aaatcaatga cccgtacggg 3772321 attcgaaccc gtgttaccgc cgtgaaaggg cggtgtctta accgcttgac caacgggcct 3772381 tcacgaaatg gtgagccatg aaggactcga accttcgacc ctctgattaa aagtcagatg 3772441 ctctaccaac tgagctaatg gctcttaaag atgtcggaat ttctatagag caaacgactt 3772501 aaatctagtt ctcatcttgt actctattga agcagtttcc gtaacaacga gatttataat 3772561 atcacgaaca aatagaagtg gcaataactt ttttggtttt ttttcatatt tttttctcag 3772621 accaacttat atgcggcttt caaacaaaaa acaagcccct taaatagggg cttgcagaca 3772681 tattctattt agttcgcacg gtacacactg cgaaggacat ttgtttgtga gcggtctgga 3772741 ccgacagaga aaatagaaag cggaatgcct gtcagctgag acacacgctc aagataatgg 3772801 cgcgcatttt ccggaagctc gctcaagctc ttcgcacctg taatatcctc agtccagccc 3772861 ggcatttctt catataccgg ctcacattca gcaagtgcct taagacttgc tgggaattct 3772921 tcaatgattt cgcctttgta gcggtacgcc acacagattt tcaacgtttc aattcctgct 3772981 aggacgtcaa ttgagttcag agaaagatct gtaattccgc tcacacggcg ggcgtggcgg 3773041 acaacaacgc tgtcaaacca gccgacacgg cgcgggcggc ctgttgttgt tccatattcg 3773101 cgtccgactt cacggatttg atcgccgatt tcatctttca gctcagtcgg aaaaggaccg 3773161 tcgccgacac gagtcgtata tgcttttgat acaccgacaa cgtgcttgat tttggtcggg 3773221 ccgacaccag aaccgatcgt gacaccgccg gcaaccgggt tagatgacgt aacaaacggg 3773281 tatgttcctt ggtcgatatc gagcataacc ccttgtgcgc cttcaaataa tacacggcgc 3773341 ccttcatcaa gagcatcgtt taagacaaca gatgtatcgc aaacatactt tttaatctgc 3773401 tgtccgtact cataatattc gtctaagata tcctcaagtt taaacccttc tgtctcgtac 3773461 attttctcga gaagacggtt tttttcttca agattgcgct caagcttttc cgcaaacgcg 3773521 tcacggtcta acagatccgc gatgcgaatt ccgatgcggg ctgctttatc catgtaagca 3773581 gggccgattc cttttttcgt tgtgccgatc ttgttagccc ctttacgctc ttcttccact 3773641 tcatccaatt tcaaatgata cggcagaatg acgtgagctc tgttgctgat tctcaggtta 3773701 tctgtactca cgttgcgctc atgaagatac gcaagctctg tgactaatgc tttcggatct 3773761 acaaccattc cgtttccgat tacacacgtt ttatccttat agaaaattcc agacgggatt 3773821 aagtgaagct tatatgtgat tccgtcaaac ttgattgtat gccctgcgtt atttccgcct 3773881 tgataacggg cgatcacttc tgcattttct gataggaaat ctgtaatttt accttttcct 3773941 tcatcgcccc attgcgtacc tactacaact actgaagaca tgtccgtgca cctccgttaa 3774001 cctttcaaaa cgattctatt caaacaaatc aagtttatca gtgaagaaac agaaagtcaa 3774061 ttgtaaatcc gaacattaat ttattgtaaa tctatattcg ttcgcttcca ttcgttttat 3774121 aagcgttttc tcactgcttt gtcataaaaa gcttgcgaaa ctttcatcct ttagcataag 3774181 aaagaatcac ttgcctgata tcccttttga attcataaaa acgatccgcc agccgtccgg 3774241 gtcctctatc gtcacgcccc cattgctcca gtacgggttc tctgattcga cctcttgata 3774301 gcccatgtgc tttagctttg aagtgatcgc tgccagttca actgcattcg gcacataaaa 3774361 aacaagaagg ctgtcgggat ggggaacggg ggcagtgctt cccccttcat actgggtgaa 3774421 ttccaaatga taatcggcat gaggaaggcc gaacatgaca ccgtcatacc cgttatgctg 3774481 tgaaaattct cctattcgtt tcaaacacag tccctcttcg taaaaacgaa taatctcatc 3774541 aagctggccc gtaggacgcg caattcggat ttgtgctgct tgaaaagacg aaaaacgttt 3774601 tcccatattg ttaccatctc ctttttgcac cattttatta aaacgctttc aatttttcat 3774661 ccgctgagcg aacgtcattt cttccatctt tcgaatgaaa aaaaccccaa gagcagctct 3774721 tggggcttat gcgccgggcg gaacgcctgc gtcatcaaaa cgccgttcca ggttgacgaa 3774781 tttgttgtat tcttttacga acgcaagaga cacggttcct accgggccgt tacgctgttt 3774841 ggcgataata atttcgataa tatttttatt ctcggtttct ttgtcatagt agtcatcacg 3774901 ataaaggaac gcgacaatat ccgcgtcctg ctcgatactt cctgattccc ggatatcaga 3774961 catcatcgga cgtttatcct gacgctgctc aacacccctg gaaagctgag aaagcgcgat 3775021 aacagggact tgcagctccc tcgcaatcga cttcagttca cgggaaattt cagatacttc 3775081 ctgctgacgg ttgtcctttg aacgaccgct tccctgaatc aattgcaggt aatcgatcaa 3775141 aatcatgccc agcccgcttt cctgcttcaa gcggcggcac ttggcacgga tttcactcac 3775201 tcgaataccc ggtgtatcat cgatgtaaat cccgctgttc gataggcttc ccattgccat 3775261 cgtcagcttg ccccaatcct cttcggtcag gttacctgta cggagattct gggcattgat 3775321 atttccctcg gcacagagca tacgcataac gagctgctcg gcacccatct caagactgaa 3775381 aatcgctacg ctctcatcgg tcttcgtcgc cacgttttgt gcgatgttca gggcaaaggc 3775441 tgttttccct actgaaggac gggcagccac aatgatcaag tcgttgcgct ggaaacccgc 3775501 agtcatccgg tcaagctccg taaaccctgt tggaattccc gtgatatcac cttttcgatt 3775561 gtgaagctgt tcgatattat cataggtctg gacaaggacg tccttaatat tttggaaggc 3775621 actcgtgttt ttgcgctgtg ccacttccat aatcgttttt tccgcttcac tgagtaaatc 3775681 ctcgacctca tcctcacggg tatacccgtc ttgagcaatc gttgtcgcag ttctgattaa 3775741 tcggcgaaga atcgattttt cctcaacgat tttcgcgtaa tattctatgt tagccgctgt 3775801 cggcaccgag tttgcgatat ctgtcaaata tgaaataccg cctacttctt ccagcaggtc 3775861 tgtgttcgca agctctgatg taactgtcac cagatcaacc ggttcacctc ggtcaccgag 3775921 caccagcatc gcattataga ttttttggtg ggacattcta tagaaatcat ctggaatcaa 3775981 tacttctgaa gccagtgtta aagcagacgg ctgtaaaaaa atagcgccta acacggcttg 3776041 ttcggcttct atattttgcg gaggaagccg gtcattcaga aggtctgtca tgctaagcac 3776101 cgtcctctca ttaaaaaatc tccaacctcc attctaccat ttctacagaa aaaaaataga 3776161 aaaattgtct gtttcctgtt tttttcagtt agcagattgg atcgtttcgg acagtaacaa 3776221 ggcgggaaaa atgcaataaa acataaggga ggaatgaaag atgataaaga aatatgcgat 3776281 tacacctaat gttgatgcgg acggctggtt tattgaggtg gagaatgtag cgccgacagc 3776341 tttgtatacg tctaaagacg ccgctattga aaaggccaaa caggtggcta aggaaaacag 3776401 tccgtctaag cttgtaattt atgaccagtt taaaaatgtg gaagaagaac actcatttta 3776461 atgaatgaaa gccttcgctg cagcgagggt tttttagcgg ttatcggttt atttcatcca 3776521 ttggatgcct atgtgcatca tcaaatctgc cgctttttga tacagatccc actccccgat 3776581 cgaagcaaat ttccccatca gctcctgaag ctttaacctc attgctatat attcttcgaa 3776641 agtgacagct ttttcagtgt ctatttggtg ttccttcagc atttgtttta ataaggataa 3776701 cggtgcgtgc ataagaaccc tccttacctc ttttataacg gtcattttcc gattgctcta 3776761 ttcctttgtg acatcttctt acatttcaca tctgattctt gtacaatgga cagaagagag 3776821 gagggatctt ttgtgagacc tttgcaaatt tctgccgaaa ctgcacaaaa gcttgcagag 3776881 tccttgaatc tgccgcttga acagatcatg catatgcctc agcatattct gcttgccaaa 3776941 atggctgaac tgcaaaaaga ggacaaatca tagccttcat tcacatactt gcttacctgt 3777001 ttcgggataa tatcatgtat atgttagaaa agaggagtaa ctgctttgcc acatccacat 3777061 aataaaaaaa tccaatcatt ttggctgatc accggcatta tctttatcgc ctttaactta 3777121 cggcccgcga tcacttcagt cggtccggtc atcagctcta tccgggcaga gctgcacatg 3777181 tccaatgggg cagccggttt tttgaccgca ctgccgctgc tttcgtttgc agttctttct 3777241 ccgcttgcac ctaagcttgg acagcgcctc ggtaatgagc gaactttatg gctaggtctc 3777301 gtgatactgc tgatcggtgt tctgactcgt tctaccggct atactgccgc tttgtttttc 3777361 ggaacagcac ttatcggcgt cgggattgcg attggtaacg tacttttgcc aagcttaatc 3777421 aaacataaat accctgaaaa gccagggatc atgatcagcc tgtatacgac atcaatgaat 3777481 atattcgcag ctttagcatc gggtgtcagc gttcctttag cgacccagat gaatggcgga 3777541 tggaaacaag cctttctctt atggggcggg ctggctttac ttgcattgct aatctggata 3777601 cctcagctgc gccatcgaga tacggcaaac cagacaatga agctgcaatc cagttccatt 3777661 tgggcttcca aaatggcatg gtatgtcacc atctttatgg gcctgcaatc gtttttattt 3777721 tacagcagca tcgcttggtt tcctgaaatt ctccgttcac acgggattga tacggcaaca 3777781 gccggatgga tggtatcact catgcaattt gcgagtctgc cttccacttt tctgacgcca 3777841 gttttagctg accgtgtgaa acagcagcgc ggtatcgttg cggcgctggc ctcagtttat 3777901 ctgatcggcc tttgcggatt attagcgggc ggaagccata cattgcttgc catctggatg 3777961 atcattatcg gtatcggaca aggctccagc attagtctgg cccttacttt gattggtctc 3778021 cgcagtgaaa atgcccaaca ggccgctgcg ctgtcaggca tgtctcagtc attcggctac 3778081 ctgctggcag cagtcgggcc aatctttgtc ggctatctct ttgaccagac gcattcttgg 3778141 acgatgccga ttgtgcttct cattgctgcc ctgatcgtaa tgggagcagc cggacaggga 3778201 gccggacgag atcgatacat tttccagtca gaaaaacaaa gaaattcagc ataaagcggg 3778261 gaagatatct ccgctttttt ctttgaatat ttatggttta ttcataagtt tttcatattt 3778321 gttttttaca atgagacacc ataaagaggt gaaaaacgat gaaaaccaaa cgattcgacg 3778381 cagcccttat tcttattttg ctagcagcag cttttttgaa tacgtatcac atttggcagg 3778441 atgatacagc aaaccagtac tatttggcgg ctgtaaaaag catgacgcaa agcttccata 3778501 acttttttta tgcgtcattt gacccttctg gatttgtgac agtagataag cctcctgtcg 3778561 tgttatggat tcaaacgatt ttcgcactga ttttcggtgt tcacacgtgg agtgtcatca 3778621 ttccccaggc tcttgccgga gttggatctg tcttccttct ctacagaatg gttaagccga 3778681 cttttggagt tggagcggcc cgcattgccg cacttgtcat ggcactgacc cctatcgcag 3778741 tagctgtcag ccggacaaac aatatcgaca gcatgcttgt ttttacctta ttgctcggtt 3778801 caacttgtct gcttagggca gtaaaacaag gcaagctggt ttggctgctg acggcatttg 3778861 ccctgattgg gctcgccttt aatatgaaga tgatgcaagc gtttatggta ttgcctgcat 3778921 ttgtgttatt ctacctgatt gcatctcggg tttctctgaa gaaaaaaatc gggtccctgc 3778981 ttctgtctct tgtccttctg acaggccttt cactctcatg ggcgattgca gtggattcag 3779041 cctcttcctc aagccggcct tatgtaggaa gcagccagac taactcagtg ctagaactgg 3779101 cctttggcta caacggcaca gagcgtctgt ttgggcaaac tacgggcctt gcaaagggtg 3779161 atatgaatgc tgctggcgga gggaacatgc agaatcaaga caacatgcaa gcgccaaatg 3779221 gcaacggttc atctttttct cagaacggta atcaatcatt cggaaaccat tcacaggcgc 3779281 ctcagccgcc taacggacaa accggcgctc tcaatggagg cggaggcaca cctcccacag 3779341 gtggcaacgg acctggaaat ggagggcctg gcggcggagg cggaaaaagc gtgaatatgt 3779401 tcggcaccgg tgatcctgga ccgcttcgtc tcttccaatc agcactttcc ggccaaatca 3779461 gctggatgct tccattctca ttgatcggat tactgggcgc aatcatcagc tggtaccgtg 3779521 atcgccgcgg acatgctgct aaaatgaaag aaacgctatt ctgggcggct tggcttgttc 3779581 ccgtggctgg tttcttcagc atcgcaggat tcttccacca gtattatttg attatgctgg 3779641 caccgccgat tgccgccctt tctggtatcg gatggtatac gatgcaccgc ttatacaaaa 3779701 ataataaaga ctggtccagc tatcttctgc cggcagccgt cttgatcaca gccgtgtttc 3779761 aggtgtatat tctgagcgct tatacaagcc aaatcggcag tgtatggatg tatgtcctgg 3779821 ggctcttagg actgggcatc acccttgcac ttctgatgct taaacgcagc catccgttca 3779881 gtaagctgct gaccatcatc agcttgtgcg ttctgcttct cacaccagtt tactggtcag 3779941 caacgccgct tctatacggt ggcaacagcg tccttcctga atccggcccg cagctcaaag 3780001 gctcagcaaa cggcgggaac atgttctctt cagaggtcga cagcgggctc ctgtcctatc 3780061 tgagaaaaca caataccggc gaagagtatt tatttgctac tttgacaacc gtaacagctg 3780121 cgccatacat catttacgaa aatgaatctg ttatggcaat gggcgggttt aacggcacgg 3780181 atcccattct gactgtgtcg gaactgaaaa aactgatcaa agaaggcaaa gtgaaatact 3780241 tccttctgtc agaaaacaac tcaggcaaca gcgaacttgt ttcctggatt aagaaaaacg 3780301 gaaaagaaat aacatctgac gagtacagcg gttcctccag cagcacaaac agcgtgcagg 3780361 gaatgcgaag aggacctggc ggagaaagcc agcaaactct ttatctcgtg gaataaaaaa 3780421 agaggcttgg atgaatccaa gcctcttttc tattaagctt cttcttttac atgtaccttt 3780481 aacacagcct gcacttcagg atgcagcttc acaggcacgt ttgtatatcc taatgcacga 3780541 atgccgtccg gcagttcaag cttccgctta tctactttaa tgttatggtc tttttggagc 3780601 tgttcagtga tttgcttgct tgtcactgaa ccaaataaac ggccgccctc acctgatttt 3780661 gcgctaagct caacagtcag tttttctaat gtctctttca agctcttagc ctgctcaagc 3780721 tcagcaatgg cttctttttt ctctttctgc ttttgtccgt ttaacgcgct gatgtttgac 3780781 gcgttcgctt caaccgcgag gcctttttta attagaaagt tatgcgcata accgtctgct 3780841 acgtttttga cttcgccttt ttttcctttt ccttttacat cttgtaagaa aataaccttc 3780901 atctctgtac gcctccctca aaatactcat ctatggcgtg cttcagccgt tccagcgctt 3780961 cagaaactga aatgccggac aactgagtcg ccgcatttgt taaatgccct ccgccttcca 3781021 gggcctccat gatgatctga acatttacct cgccaagcga ccgagcactg atacaaaccg 3781081 tttgttcatc ccgtctcgcc accgcaaatg aagcctcaac ctcactcatc gatagcagcg 3781141 aatcggcagc ctgcgcaatc agcacttgat cgaagtattc ctcttcattt tcaggaagag 3781201 aagcaatcgc aatgttatct ttatagagga ccgtatgctg gatcagcttc gcccgtttaa 3781261 tataggaatc aacggtttct ttcagaaact tctgcaccag caccgtgtcg gcgccttttg 3781321 cccttaaata agaagccgca tcgaaagtcc gcgagcccgt gcggagagaa aagctctttg 3781381 tatccactat tataccagct aatagggctg ttgcttcaat catattgatt tttaagcgct 3781441 tcggctgata ttcaagcagc tctgtcacca attccgctgt ggaagaagcg tatggttcca 3781501 tataaacgag cagcggatct ctgataaact cctcacctct tcggtgatgg tcgatgacca 3781561 cgatatgttc aattttattg accagccgtt cctccatgac gagtgacggc ttatgtgtat 3781621 caacgatcac aagcagtgtg tcatcattgg aaatctccat tgcttcttca ggcgtaataa 3781681 atcttgacca cagttcttca tattttttga tttccccaat caaacgctgc acacttgatc 3781741 cgatttggtt tgggtcaatc acgataaaac catctttgtt atttgcctga gccaccttta 3781801 aaatcccgat cgctgcgccg atagaatcca tgtcggggaa tttatgcccc atgataatca 3781861 cattgctgct ttcggtgacg atttccttta aggcgtgaga aatcacgcgg gcccgcaccc 3781921 ttgttcgttt ctccattggg tttgttttac cgccgtaaaa cttcaccttg ccgtttggca 3781981 gcttaatggc tacctggtct ccgccgcgtc ccagtgctaa gtccaagctg gattgcgcca 3782041 aatcgccaag ttctttcagg gaagagactg aagccccgac accgacgctt aacgtcagcg 3782101 ctacaccgtc aaacgaggtt ttttcccgca cttcatcaag aatcgaaaac ttcgaatttt 3782161 cgagttcagt taagatatgt tcattaagta cagcaataaa gcgttctgaa gacgtccttt 3782221 tcaagaagat cccgtactcc tgcgcccaag cgttcagcaa agatgtcacc tggctgttca 3782281 tcgtgcttct cgtctggtca tccaatcctt gtgtcacatc atcatagtta tcaaggaaaa 3782341 tatatgccag gacggttctt tcgttttcat atagcttttc aatctggatt tgttctgtta 3782401 catcaaagaa atataagaga cgctcatccc gtttgatgac aaccctaaac ttgcggtcat 3782461 tcaatgtaac cgtttccgat tccacctctt gtttgataag cggcactacc gattcacaag 3782521 tatcgtaaag tgatctcccc actaaagtgc tttcattaaa acaagaggaa agaaacggat 3782581 ttgcccattc tatataatat tggtcattaa aaagcatgat tccaatcggc atttccatca 3782641 atgcctcttc accgactttt ttcaacctgt aggacaacgt agaaatataa gcatcaatct 3782701 cttgtcgaat aagagaatca gcacgcttaa taaaaaacaa aataactgcc agcagcagca 3782761 cttcgacggt tcctaatatc cagttaaaat aaaagctgat gaggattgta ataattgaca 3782821 gagcaatcaa tgcatagatg ggataccgaa acagcggttt ttcataaaag cttggcattt 3782881 ctatcactcc ccaccatgtg agtaaaactc atgttcactt caccttattc cttatatgaa 3782941 agcccatatc taaaacgcct aaaatgcgaa tggccgccat gaagaccgga tgcacaaacc 3783001 caagtatgac agcaatcaca gccgcagcct ttggatattg tttcttatgg caatagaaaa 3783061 agataaatga taaaccttgg atgaaaatca gaaacccgag tataaactcc ccatttaaag 3783121 cgatagagta cagcatttgg cctttttcta aaggcaaaaa tgaaagcatg acaataatca 3783181 aatacagtac tacaacactt tgcggaaact tcaactctct aaaaggcttt agattaggaa 3783241 tatcggggga gaatcgcctt aagagcggct tagcgataag gtaactgagg aaagaaaaaa 3783301 taactcctac catcacaata gctgttggaa aaagatattg aacgataccc aattgttctt 3783361 ccatcagttt taattgcttc tcaaactgcc cagcattgcc cgactgcttc gctacagttt 3783421 ctacaatatc aagagattgc cggtattgtg tcattgcctc atcaatgata ttgataccca 3783481 aaaactgaat gcttatcaca aaatagaaga caatactaag catataaata agagcgcccg 3783541 aaataatggc gtgcccgggc tctttccttt tgaaaaaatg tcccatggca atgccggcgc 3783601 aagctgacat aaaagctaca ataagcccgt taaaggaccc gacaataaaa acaaccggaa 3783661 gactgacagc gcccatccat atccctagct tcaatccatg tctgatcgta tacaagatca 3783721 ttggcagcgg cagtgcaaat aacagaattg ttccaatcac aggaacataa acgaccagaa 3783781 gcgtaatgat cgcaaacaga ctgattaaaa tagcaccttc cattaaagct ctcgtttgtt 3783841 tcacttagtc acctcgtatc atcctgaaca tacgaataga aaagagcagc ataaacgact 3783901 gctcttttgt tcatcgctgc aacatgcttt gcaccgaatg tttttatatc atctctaaat 3783961 tttactttta tattttaaca taagtccaaa tcgcaagtaa aatgacgcta atgtttcatg 3784021 tgaaacatga aaaaggaaaa gacattcttt gaaaagaatg cccatcacaa ttaatgttta 3784081 tcatccataa agccagaaga ttccttgttt ttctttttcg tttttctgac atacataaaa 3784141 attaagatca ccagtaaaag ggttgttgct tgcagaacgc cgctgctaaa caagaaaaag 3784201 ttctttatca tgtcccacat tgtgtttcac ctctttgtgc atgttctcaa cccgtatcct 3784261 atataaggtg aatttccctt tttaaaaact tcaaaacatc atgaacaaca ttgagcgttg 3784321 ggcatatgct gatatggaat ctgatcgata aaggagaatt ttcacatgga tgaacgcaga 3784381 acattggctt ggcatgaaac attagaaatg cacgagctgg ttgcttttca atcaaacgga 3784441 ctcattaaac tgaagaaaat gataagagaa gtaaaagacc ctcagctcag acagctttat 3784501 aacgtgtcta ttcagggtgt tgagcaaaat ttgagagagc ttcttccgtt ctttccacag 3784561 gctccgcaca gagaggatga ggaagaagaa cgcgcagata acccatttta cagcggtgac 3784621 ctgctcggtt ttgccaaaac atctgtccgc agctatgcca tcgcaattac agaaacagca 3784681 acacctcaat taagaaacgt actggtcaaa cagctgaatg ctgccatcca gctgcacgcc 3784741 caagtttatc gatacatgta tcagcatgga tattatccgt cttacaacct ttctgaactg 3784801 ttgaaaaacg atgtcagaaa cgccaacaga gccatttcaa tgaaataaaa caagcagcaa 3784861 aggagttccc tttgctgcta tttctgctga tccttcacta agccgttcga acgataagat 3784921 tccagcacgt ctctgttgga ttctccccat tctttcattt gcaaaacaat cggttcaagc 3784981 gtgcgcccaa attccgtcag agagtactct accttgggcg gcacctggtg ataaacctca 3785041 cggtgcacga tgccgtccgc ttccagctcc ctcagctgga gagtaagcat tctttgagta 3785101 atactcgggc agattcgccg aaactcatta aatcgtttct tgccatctat catgtgataa 3785161 aaaagaattc ctttccactt tccgccaatg acatctagag tgaattcaac tggacagcct 3785221 tctttgttcg ggtatatatt ctttttttca ctcattcttg accctccaat agtacctttt 3785281 ttgatactac attacatttt gcaactaatc tacccagtat tttacacacc ttttctcctt 3785341 agctcaaaga aaatgcttct tattcacatc aatttttaag ggtttgcatg attacacctg 3785401 cagcaagacg tgttaaacta tataaagatt acactactta aaaaaggata ggagctatca 3785461 tggaaaagat acttattttc ggacaccaaa acccagatac agatacgatt tgttctgcga 3785521 ttgcttatgc tgatttgaaa aacaaactcg gcttcaatgc tgagcctgtc cgcctcggac 3785581 aagtcaacgg cgaaacacaa tacgcgcttg actatttcaa acaagaaagc ccgcgtcttg 3785641 ttgaaacagc tgcaaacgaa gtaaacggcg ttatcctggt tgaccataac gaacgccagc 3785701 aaagcatcaa agacattgaa gaggttcagg ttttagaggt tatcgaccat caccgcatcg 3785761 ctaactttga aacagctgag ccgctttact atcgtgctga gcctgtaggc tgtacggcta 3785821 ccatcttaaa caaaatgtac aaagagaata acgtgaaaat cgagaaagaa attgccggcc 3785881 ttatgctgtc tgcgatcatt tctgattccc tgttatttaa atctccaact tgcacggacc 3785941 aagacgtagc agcagcaaaa gagcttgcgg agatcgctgg agtagatgct gaagaatacg 3786001 gcttgaacat gttgaaagca ggcgctgatc taagcaaaaa aacagtggaa gagctcattt 3786061 ctcttgatgc gaaagaattt acactcggca gcaagaaagt cgaaatcgca caagtaaaca 3786121 cagtggacat tgaagatgta aaaaaacgcc aagctgaatt agaagctgtg atctcaaaag 3786181 ttgtggctga gaagaatctt gatctgttcc ttctcgttat cacagatatc ttagaaaatg 3786241 attcacttgc tcttgcaatc ggtaacgaag cagcgaaagt ggaaaaagcg ttcaacgtta 3786301 cattagaaaa caacacagcc ctcttaaaag gcgttgtttc ccgtaaaaaa caagtcgttc 3786361 ctgtcttaac agacgcaatg gctgaataag caaaaagcat cccgcgtcgg gatgcttttt 3786421 cttattcacc cagcttctca atttgtccca tcacatcagt aatttgcttt gcgttttgga 3786481 ccaggtctga ctgctccaat tctttaagcg ataccttgcc ttcctcggct tgtttcaaca 3786541 catcttcagc gcttttctgc aaggtttcgt tatgctcctg aatggttcga tgaatctccg 3786601 ctgcggcatc aggcggcgtt aattcattaa aatcagcggc agccttctga atcgactcaa 3786661 gctgcgcttc aagtttttct ttcgcctcgg tgtcatttac agctttctca gccaattcag 3786721 gcgcttcctc tgcaaatgtc ttcaccttct ccacataacc agctgcttca ctcgtatagt 3786781 tcaatccgtc gttcacctga tcaagcatgc cgcatccgcc tgcactcaaa agtcccactc 3786841 cggcaagtac tgtcaaaatg atcttcatct tcagccccct catcgtttct ttttcatttt 3786901 ttcttttaag atcggaatca atttctcttt cgctaacggc agccctttcc tcaccaattc 3786961 acgcttcagc cactttttca gcttagacat tctgatgctc ctctcccttt ttgataaaaa 3787021 tgaaaaaact ccaccaattt ggtgaagttc ctgaaacaaa aagaccttca ccaaatcaga 3787081 tttggcaaag gtctcgctaa caatgagatt gccagcaaag ccgaggacac cttgtcccgt 3787141 aatgacgact ttactgtgaa agctactccc ctttggagtg ttcattttta ttactttcat 3787201 tctaaagcac cgatctgttc cagtcaaatt cctgccgttt atataaaagc gcgctgtggt 3787261 atttaaaatt tgaatggttt ttctatcagg agatcatgct atgacagagg aggttttcat 3787321 catgagtcaa gagcgcgtga aacggcctgg gcataccaga tggtacatat cttcgttact 3787381 tagcggcatt attattctta attattttga ccgagtggcc atctcggtag cggcccctgc 3787441 gatacaagat tcgtttcacc ttactgcaac tgaactcggc atcgtgtttt ccatttacac 3787501 ctattcctat acactgatgc agctgcctgt cggaagtttg ctggaccgtt ttggggtcgc 3787561 atgggtcacg agggttggaa tgacaatatg gagcttttta acgatccttc ttgctttttt 3787621 gcaaggaaaa ttgctgttgt atctgttccg gtttctcatt gggctgacga gcgcctctgc 3787681 gttccctgct gcctctaaag caaccgctct ctggtttcct ccaagtgagc ggggattggc 3787741 aaactcactg ttcgattcgg ccgccaagtt ttcaaatgta atcggcgcgc cattggtcgc 3787801 ctttcttgtc acaacatttg actggcgtgt cgcttttttg acgattggat gcatcaatgt 3787861 gctgtttacg atctttttct ggcagtatta tgaacagcct gaacggcaca aacgcatttc 3787921 taaaagtgaa ctaaactata ttcaaaaaca caatgccatt acaacagagc aaatccctta 3787981 caaaacgggc ccgcttttaa aaaagctttt caccaatcga aaagtatggg gcttaatgat 3788041 cggatttaca gggtacgggt atacattcaa cctgctgctc acctggcttc cgactttctt 3788101 taaacataca tacggtatgg atctcatgtc gtccggttta tttacggcag tgccgtggct 3788161 gatctcaacc atttccggaa ttgccgtcgg cggctggctc gtcgattatt ttattaagaa 3788221 aggctatcct aataccaagg tgtaccgaac cgtaatcata gtcggaatga gctttggctt 3788281 tttcttttta ggatccattc tgacgaacaa tattaccgta gccattattt gcatttccat 3788341 cggactcgcc ggaatttccg caaccgctcc ggtcggctgg tccatctccg cagaactcgc 3788401 gccgatcggt tccgtatcca tgctgagctc catggtgaat ctcgcaaaca acctgttcgg 3788461 aggcattatt gctgcgtcac tgacagggta tttgtttgat gtgacaggct cctttaccct 3788521 cagctttctg gtagctggtt ttgtgctgtt gctgggattg gttttttatg tgtttgtatt 3788581 aggggatgta aaacgaatta aactatagaa catgaaaaag agagctgcca gttggcagct 3788641 ctccctttac atcaaagaat cggcccgtcc ccatttacct tctcctcgtc ctgttcctct 3788701 atatcaagcc ccgaagctag catttcctgc tctatctgtt cgagcacctg ctcgtttttt 3788761 ccttgaagac caccttcata atgaaaagca tcctgtgtgc cgttttcctc tattgtcgct 3788821 aaaatatcgt ggatatcatt atggtctcct gaaatggagc cgaatccctg gttttgtttt 3788881 ttataattca caaaaccgct ggggaggttg tttccgaggt ttacacatga tgcgctccga 3788941 gtagtaattc atcagtgtat caaaatcttc attttggatt gccacatcac atgcagagat 3789001 gatgtctttc aattgctgtt ccaaatgaat tcccctaatc atcatgattg gatatattat 3789061 acaatgtttg acacgtaggg atccttttca tttttgtttt tacggtttcg ctggtccatt 3789121 tccgcagagc tggcgccgat cggttccgta tccatgctga gctccatggt aaatctggca 3789181 aacaacctgt tcgaaggcat tattgcggct tcattgacgg ggtattttgt ttgatgtgac 3789241 aaggctcctt tacgctcagc tttctggtag ccagttttgt tctgctgctt ggattggttt 3789301 tttacgtgtt tgtcttaggg gatgtaaaac gaattaagcg ggaataaaga gtgcttgtag 3789361 agaaaacgtt gttctttcta caagcttttt agttttgtgc tgtttttcaa gatattcagc 3789421 tgtcataaaa agaaaatgag ctcccacata ccggctaggt atgtggcgtt cttcttcatg 3789481 ttctggcatg cagctgtgag gaggatttgt ttgctcaccc cctgaacctg cgatagctaa 3789541 gcccgtgcag ttgttttgaa cctacaaagc ttcgttctat tttttctttt ctttttttag 3789601 agatttcctg aaatagaaaa gcaatctttt ctaacctttt ctttatggtt ttgccataca 3789661 taccgagtaa cgactttctg gcgtttcgtt gattttgtgt aatattctca aacatatttc 3789721 aggatttgat ttatatgacc gatagtcttt gcgatcaatt gttgagtacg taagtgtatg 3789781 ctgattcaac aaatgtatct gtattgttca ctttataatg aaatttccat tttggaagca 3789841 aacccctgac tgggtgataa cgtctatgtg cgatggcacc aaaaacttgg aggtcaaata 3789901 gtcctttaga gatgagagtt gttaagtagc cggaatctag agcgacggct tctacttgaa 3789961 aatcaaatca tgcaatttag tgatccaatc ggtcaaggta gggcttggaa cagaatcatg 3790021 gacttttctg gagttgcaaa ctattaatcg tcctcattaa atttataata aaaatattct 3790081 caattgagca aatcgcccac cctttttcct ttataacata aaatccaata ctatcaataa 3790141 aattctttac aggttattac agttaagata taatatagtt aatcttttac gtaaaaggag 3790201 gtttttatta cttgtgttga agttttaaat aggagtaact ccatctcccc attacggtct 3790261 tcatttaatt tcatcctgag ttttatttag ttagatataa aaacgaaaat ttcacattat 3790321 ttttaactaa ccgatagtat aaaatatata ttgaaaggat tgtaaaatta tgaataaatt 3790381 cctgaagagc aatttccgtt tccttcttgc ggctgcttta ggcatatcat tacttgctag 3790441 tagtaatttt ataaaagcca gcaatgataa ctataaattc catttacttg taccttatgg 3790501 ctatggtaat gcctattcaa atgatgcatt tagacagacc actcatacag ataatccttg 3790561 gaaagtaaat ttacagaaat cggcagaagg taaaggtaca atcatgacat tttggttgat 3790621 taacacaggg aatagtaaaa ttccaaaagc ttctaaaata cataacgtaa aacaaggaag 3790681 cggagctcat tattatcatg caaatagcca gggaagccat acatatgtag ccttagcagt 3790741 tgaaaacaac aattacagtg caagttctta tggtatagat ggtgtatggg atgaagaaac 3790801 ttggtaaaca agaaccttct aaaaacgttg gcacctttta gccacgcgaa aaaatttaga 3790861 atgataatct ttttataaga ttatcatttt tatttattct attaagaatt gagtgagaac 3790921 atggaaagtc atatttatcg cattatcaaa aataaattaa ctataataat atttactata 3790981 atcatattaa ttccttgtgt tgatatatca ctattgttaa tgactaacac agaataccat 3791041 cctgcatatg cgtttttcct ttctggcact tccgtagggc atgcttcaca aatgatccta 3791101 ttatggtttc ttccgcttta ttttttgtta ctatgtgctg acgattctat acaagattat 3791161 aaaacaggat atcattacat tcttataagc aaagttggca gaaaaaaata ttgtttggaa 3791221 aaaatattta cctcttttat catttcattt ttgacaatgt ttttgtcact aatattaaac 3791281 tttttattgg ttcaggtttt cttttttaaa ggtacattta aaaatgactt agaccaaatt 3791341 aaattccctg ataacagcct ttatactttt agtatggccc atccttatat agcaattgtg 3791401 ttattttcta ttatttgttg tattatgtct ggatttgttg gagcacttgg ttcaagcctc 3791461 agtttacttt ttcgtgataa gaagtatgcc tacccagcaa gtttttttat ttggttcgta 3791521 cttatactaa aaaacaaatc attaatgttt ttattccaac cgtttacaga atacggttat 3791581 aatgtacttc tccctatcct atgtttgtct atctttattt ttctaataat aatttctagt 3791641 attgttttat atgaggcaaa atacaatgaa aattaaaaga ctactattaa ttttatgttt 3791701 actactattt ttagttactt tatggttcaa ccagaaccac acttatcttg gaaagaattc 3791761 tatcgcgtca ttactatata tgaataatag tacattcgga tatagttcaa tatttgcata 3791821 taccttgttt tatattgtcc cgtttcttat gttacttagt aacttttttc attcagaaaa 3791881 cccctacaaa gtaatgagga tggttaagcg taaaaattac tacaagtcta aaattatgga 3791941 gattgggttt gtttctttac ttttttcttc aatacatact gttattaata ttacgtgtac 3792001 acatattttc tttagtaaaa acttgttggt cgaagcaaac tttttatcaa tttgtttatt 3792061 aaacatgatt agtttagtgt ttttctactt atcagtaggt attatgttta gacttacata 3792121 cgatctgttt aattcagtag cattagcaat ttttattgtg tatataattt tagatagctt 3792181 gtatttcggc gttaaattat tacttcctaa tggatattgg gaacccttta gagacttggc 3792241 tatattcaca aatatgctca atagatattg gtcaacttca aatcttataa tagtttatat 3792301 tagacagata ataatagttt ttatttttta tttagttgga tcttcaattt ttttgaataa 3792361 ggattataaa aaatgaggat taaaggcttt ttcataactt tagttgcgat aatatttcag 3792421 gcgtcattat cgagttataa taataataaa aatgtctttc cttttttaga tggcatacca 3792481 ataagcacct cgggtcatta tgagtatcaa aatattttat tgtggtttgt acctattgtt 3792541 tccctaagtt tttgtttctc tgggagtatt agagatacat acatttcgta tgagcaatta 3792601 aagttagtaa gagaacatag tagagttaaa tgggtaacat ctcaattctt aataattaca 3792661 gttgtacttt taatctttac tttatctcag attgctatat tttatattta ttcacttgta 3792721 tctcttcata accttgatat taattccgtt atcaataaaa gatttgttat gatgacactc 3792781 atgtattatc taaccttact taacttattt agttttcaat tatttatgga gctttattat 3792841 aaatctcaaa tagcacaatt aaatataagc gtttatatta ttttttcgtt aattttagca 3792901 aagaagttag tgcaattaaa ttctccgaaa gttattcact actttttaat tccaaactac 3792961 agtaatggat taagaactgg gttaagctat tattcccaat ctggaactgc tattattgaa 3793021 ccattattag gtttgtttat tataatcatt ttacagattt caatagttat attatctgtc 3793081 ttaaagttca aaaaaataga tatgctaaaa agtgagggct tacaatgatt gaggtattaa 3793141 acctaacaaa aaaattaaaa agactacagt tttagataat atctcttata catttgaaaa 3793201 aggaacaatt tatggactat ttgggagtaa tggttctgga aagaccatgc tacttcgtgc 3793261 attatccggg ttaatagtcc ctactgaagg gagtataact attaaaggtg aacaattaca 3793321 taaagatatc tcttttccta aaagtgtagg attaattata gaaaatatgc agttacttcc 3793381 tcagtatgat gcttttacta accttaaaat tttgtcaaaa attaaaaaga tcgcatcaga 3793441 taatgatata ttagattcta ttagtagagt tggtttggaa aattttaata gtgtaaaggt 3793501 tagtaaattc tcgttaggaa tgaaacaacg attaaatatt gcacaggcta tttttgaaaa 3793561 acctgatata ttgctacttg atgaaccaac aaatgcgatt gatgaaaaag gagttgcatt 3793621 tgttcatgac attcttttac aagagaaaaa aaggggagct accattatta ttactagtca 3793681 tcacaaggaa gatattatat ctttatgtga cattgcatta gaaatgaatc atggacgtct 3793741 agaaacttca gaaaaagtaa tatataagaa agatagttag tttaaactgg ctatttctta 3793801 tccaatgata gactgcagac aagttcaact gctgtaatgc tagaaaatcc aatgaaatgc 3793861 tgataattgc gaagagatat gatcagtcag aaaacaaatc ttaaaaagaa aaagtaaatt 3793921 catcaatatt tctaataaac ctggcaaaca acctgttcgg aggcattata gctacttcac 3793981 tgacgggata tttatttgat gtgacaggct ccttacgctc agctttctgg tgccggtttt 3794041 gtgttgttgc tgggattggt tttttatgtg tttgtattag gggatgtaaa acgaattaaa 3794101 ctggaataaa gagtgcttgc tgaaaagcac tctttttctg catcgaaaga atacttaaga 3794161 taagtcactc ccaaaaatcg taacagtctg acggttaaac ataaacctct gcccgttcca 3794221 ttttaatacg gtttgaacat atcccaatga gtcggcgtta taccttcccg ctatccgctg 3794281 gtacgccaat aattcgtata cgccgtctct gtcaaaatca accggataca agcccgataa 3794341 aggattcacc catccttcta tcggcatttt taacacacct tggctgttat aaatctcatt 3794401 caaatattcc ctgcccttgt aagtaaggtc gaggatatac gtttcgtttt gctgatgact 3794461 gataacgctc gctttatatt gattttgata cctcacactg tactttaatt catcattcaa 3794521 tacatctgaa ttgaaaattc gccggaactg cctgtttaga taggcaaaca catatgcata 3794581 aatagcaccg ccgcttcccc ctgtgtccat tactactgcc acatcctcaa tcttgtcgcc 3794641 tgtcatatcc cccagaaaaa gtgacggatt gtatcccata ttgttttgaa gctgaatccg 3794701 ctgctcctga tgggttctgc catcacggat caccaatgtg atatttctcc ataacgggct 3794761 gccgggcatt tgatttccag ttagaaagac ctcgtcaata acgccgtctc ccgttacatc 3794821 gccgcgggta gatacaatga ttgcacgtga ggagacaggc tgccgaaata cgtatggatg 3794881 ttgaacaagt cctctgcctt cataaaacca ataaggagcc attctgatgt catacacatt 3794941 caattgtgtc accttcccta atcagctgaa tgaatcatta tatgcaggaa tggcacatca 3795001 aagacatatc ttacacacca attaaatccg taccatatga attatcaatt acacaaagcc 3795061 actcgccttg cgcattcttt ttaaatacat aggtcgccct tctttccatc gcatactcgg 3795121 agtccttttt atccgaatca agcagtgtct gagaaagaac gagtaccgtg tcacctgctt 3795181 ccaacaggat cattttccct tgtgtcggga caatatgatg attgaaatag ttcgcaatcg 3795241 tgataaacgc ttttttgatt tcttccttgc ctcgcgcgat catgcccggc ttcacaacta 3795301 aaacggcatc ttccgaataa taattcatca gtgtatcaaa atcttcattt tggattgcca 3795361 aatcacacgc agagatgatg tctttcaatt gctgttccaa atgaattccc ccaatcatca 3795421 tgattggata tattatacat cgctagacca ctgaaacctt gaaaacaaaa tgaaaagtat 3795481 ccttttttcc tatataatca aatagatata tttaacaaag tacccaagtg aaggggtgaa 3795541 cattattgtc tgcggaagta acgttacatg acaatataca ttatgattta agtgcggatt 3795601 gccagcactg ttttggcctg tgctgtgtcg ccttgcctta tgcgaagtcg gcagattttg 3795661 cttttgataa agacgggggc acgccttgcc gcaacttaca atcaaactat caatgttcta 3795721 tacataaaga tctcagagaa aaaggatttc gaggctgctc tgcatatgaa tgctttggcg 3795781 ccggccaaaa agtatcccaa atcacttatg agggaaagga ttggcgaaac agccccgaaa 3795841 cggccaacca gatgtttgac gtttttccta tcatgcagca gctgcacgaa atgctctggt 3795901 atttacatga agctctttct atagatatag ccaagccgat tcattctgaa ctgagaacca 3795961 ctttcgaaaa aatagaaagg ctcaccagac tcagcaaaga acgcttgctg acactgcagg 3796021 tggacgagca tcgagctgag gtcaatgaat ggctgttaaa aacaagtgaa ctggtgcgtg 3796081 cccaagcccg ccatccaaaa ctcccgaaaa aggtcagccg gggaagtgtc ctgatcggcg 3796141 cgaaactgaa agggcttgat ctgcgaggag caaatctaag aggggcgctg ctcatagccg 3796201 ccgatctgag aaatgccgat ttgagaatga cagactttat cggtgcagat atgagagacg 3796261 ctgatctcag cggcgccgac ctgaccggga gcatcttttt gacacaggca caggtgaacg 3796321 ccgccaacgg cgattcgaat acaaagctgc cgctgtctgt acgaacccct gcccattgga 3796381 aataaaaaag gacccgctaa cggtcctttt ttactgatca attcaatcct ttttcgttcc 3796441 tcttatccgg cattttcaca cttcttgcca agtatcccga cagccataac gcaaccagca 3796501 gcatgaaggt gatcataccg acgacgccca gccagtgaaa accagaccag aatagccctc 3796561 cgattgttcc gaaaacactt gaaccggcgt aataaaagaa caaatacagc gatgaagcct 3796621 gtgctttgtt gtgaagggct ctcctgccca cccagctgct ggcaactgaa tgccctccga 3796681 aaaaaccgaa tgtaaagagg gcaatcccca gaattttcac tgccagcata ttgtttatcg 3796741 taaataacgc acctgcaatg acgatgaaaa tattcatcac caatattttc ggatagccat 3796801 accgatcaac cattcttcca atgaaagacg agctgaaaat gcctacaatc atcacaataa 3796861 agatccagct ggaaaatgct ttattaagcg aatacggcgg gcccaacagc acatacacaa 3796921 tgtaattaaa caaggcaaca ttgcttccaa gcagcaaaaa accaatgaga aacaagctga 3796981 atagtttacg gtccctcaag tggccgatca gagacattcc caatttcccg agcttcaatt 3797041 ttcttggcgt aaaatgcctg gatggcggca aatttataaa aaatataaca ctagcaatca 3797101 aactaatgac accaattgtc cccatcgcca tatgccaatt caagtactcg ctcaggagcc 3797161 cggaaacgat ccttccgaaa acggcgccga ttgcatttcc gctgatatat agccccatcg 3797221 ctgatccaag acttccgggt tcaatttctt ccccaagata agccatcgca atcgacggaa 3797281 ggcctgcgag cgcaacgcct tgaatggttc tcaatacgag cagtgtatga aagctcggac 3797341 taaaggccga tgccagacag agaaccgatg cggccagcat ggaaataccc ataataggct 3797401 tgcgtcccca cacctcggat aatgaaccaa agacaagcat gctcacagct aacagcattg 3797461 tggtaacaga taaagaaaga ctcgccgcag taggcgttac atgaaattcc cgcgtgaatt 3797521 cctccatgag cggctgtacg caatatagaa tcgcaaatgt attgaaaccc gcagcgaaga 3797581 aagcaaacgt aatttttcga aaaaccggtg tgccttttcg aatgtatgtc atcgggactt 3797641 tatcggtccc tcatcatgtt gtggagcact gccattcata aacaatcatc ctttatttct 3797701 tacgaattca aacatcctcg agtctgttta tattattatc ttagcaccgt tgatatatgt 3797761 tgtataatgc atataaaata tccttttcat gcttatatgt aataaggaga gatgataatt 3797821 ggaatgggaa caacttgaat attttcaaac actggcccgg atgcagcacg tcacgaaagc 3797881 cgcaaaaagc ctctccatca cacagcctgc actttcacgc tctatcgcca ggctggaaaa 3797941 tcatttgggc gtcccgctat ttgacaggca aggacgatcc atcagcttaa atcaatacgg 3798001 acacattttt ttacgacggg ttcaggcgat gatgaaggag tataccgaag gaaaagaaga 3798061 aatccaagcc ttattaaagc cagaccaagg cgtagtctct ctcggttttt tacatacatt 3798121 aggcaccacg ctcgtgcccg atctcatcgg ctcctttcag caggaatacc ccaacatttc 3798181 cttccagctg aagcaaaacc actcttattg gctgcttgaa cgattaaaat ccggagatct 3798241 ggacctctgt ctcctcgctt cgattaagcc tgaaaatccg atccaatgga tcaagctgtg 3798301 gagtgaagaa ctctttgtat ttgtgccaaa tgatcaccca ttagccagtc gcgaaagcat 3798361 taccctgaat gagattgccg gggagcgttt tattttattg aaaaagggct atgcgcttcg 3798421 gatgacggtc gatgagctgt ttgagaaggc caatatacag ccgaacatta tgtttgaagg 3798481 agaagaagca actactgccg caggttttgt ggcagccggt ctgggcatat ctattctccc 3798541 agacctgaaa ggcttagacc aaagcaaaat caccaaaatc cgcgtcagct ggccggaatg 3798601 tcagcgtgtc ataggaattg cctggataaa aggcaggttt ttatcaccgg ttgctgagac 3798661 ctttaaacaa tatgtgatca gccatttttc tgagtaggaa ggattcaagc atgaatgtca 3798721 aaaaaatcac gtcagaacag gatttacata cagcgtttga aatcagaaag gcagtatttg 3798781 tagaggaaca aggctgtccc atttcggatg aattcgatga gttcgataca ctccacggtg 3798841 actgccagca catcctggct tatcatcaga atgtacctgt tggcactgca cgtgtccgta 3798901 tcgttggcca cacggggaaa ctggaacgaa tctgcattct gaagtcttac cgcaaattcg 3798961 gtttgggaaa agtgatcgtc gatgcattag aacgtattgt aaaagaacaa ggcatttctg 3799021 ccttcaaact gcacggccag acacaggcgg caggctttta tgaaaagctc ggctatcgga 3799081 ctgcatcaga agaatttatg ctggacggca ttccgcatgt gctgatgaca aaacaagacg 3799141 attctgcgct atagattgtt cacaaatttg tcacttatga gcatgaacgg ttcattggta 3799201 tactaatcac cgattatgga gagaaggaat gattgtatgc cagcaaataa aaaagaaggc 3799261 cttatatttg gcgtgatgat gtgctttgga atggtttgcg tcatgtcgat ttacaatgcc 3799321 atcatcaacc gagccatcta cgatttttca ctgatgaccg tttttgaaat ggtcatcggt 3799381 tttatgatcg ccctcctgtt agatttactg ttagtgggcc ccctcgccaa gaagattgca 3799441 ttccgcatgc cgttcgacaa gactaaaaaa atttatgtca tccttgccat gtcaacttgt 3799501 atggtgattg gcatggtact ttgtatgtct gtgttcggtt tagtgacagc ggttctagca 3799561 aatgggctga acggggacag cctcttcagt gcttatctta tgattgtgtt gaaaaatttc 3799621 atcctggcct atccgttgca attactgatt atgggcccat tagtcagagg agttttcatg 3799681 aaatttgtaa aaccaaagct cacagccgca atttaaatag aaaaggagtg agcctgacac 3799741 tcactccttt tgctcatgaa tcgaatgtaa aacaagctcc gcaaaagcct ctgcggcagg 3799801 cagctgccat tttttctttt tgggtgtgag taaatcggat cgagggcttc accatgctgg 3799861 agatttttca gcttatgttt ttcacttcca ttaatcccta taccttacca catagttttt 3799921 atacaattct tcgttataaa ggatttcttc gccatgtgaa gagcaaatga gcgttggttt 3799981 gatttgatct atgattgagc cgctgtcgat gttctcattt atatcaacac tgaatcttct 3800041 tataggtggg tgtaaatcct ccttacttgt gataaaaagg tcgcccgtca atagcgtacg 3800101 atcgatttta tgataataca caacatgccc cggcgaatgg ccaggtgtta aatagtattt 3800161 cagaggcaga tgagcaagcg tttgctccgt cagcggctgt acaatatggg ctacccctgt 3800221 gttctccact tcatttttgt tcggatatgg ctcttcccca ttgatgtact ttagttcttt 3800281 ctggtgcgca aaaatcggaa tatcaaatct ctctaaccat tttgatgcac ccccgatatg 3800341 atcactgtgg ccatgggtaa gcaaaatggc ttttggattg ccgatcgcta acgctgccct 3800401 aatttgagca tcagcaaaac gttctattcc cgtatcaaca atataaacat catcaccatc 3800461 tttgataaac caggtatgaa ccggaatacg aagaggcaca tcaagctcaa attcacattg 3800521 aaagacatgt tctgatagtt gtctcaaatt cacgcaaacc atctcctgtg gaaatttttt 3800581 gatagtttta aagaaaacag aagtgaacgg actattttca cccacgctcg agctgactgg 3800641 attcttgaga ggaaacgccg attttcgcca gcatcagctc aacttgttaa cgttgtccat 3800701 taataatccc ttttgttccc cttcttcaca tattcccaat cacgttctat attcttcctc 3800761 actctatgaa ggagtgcaga aatggtttcc ttttcctctg aagtaaaacc ggacaaggcc 3800821 acttccgtgg aatgttctcc ttctcttctt aacaatggat ataccttttt ccctttctca 3800881 gtcgggaaca gtttttttat ttttttattt tgctcatccg gcagtttttg aataaatccc 3800941 tgcatttcca gcttcttaat ggcccgcgcg gccgttgtcc ggtccacttt tatcatttcc 3801001 gccaattttt cttgaataat tcccggattt tcgtatatac gcacgagata gagatactgc 3801061 cctcttgtta agtctaaatc tttaaattcg atgttgctta tggaatccaa cgctcttgct 3801121 atcatgccga tctcacgcaa aatatcattc attcctaaaa cccctcacgt atttttgttg 3801181 caattacaac aaaaatgttt taaccttact attataagac cacatgcgtg ctgtacagtc 3801241 cagactaata tcagaaaagg attgattcat aatgaatata aaaagaataa caactgaagc 3801301 tgatttacat gaagctttaa agattagaag aggcgttttc attgaggagc aacatgtgtc 3801361 tgaagccgat gagttcgatg aatttgatac gcttcaggaa caatgccagc atatcttggt 3801421 atatcatgag aatcagcctg tcggcaccgg acgcgcgcgc atcgttggcc atacagcaaa 3801481 gctggaaaga atctgcatcc taaaacctta ccgtaagtac ggattgggga agatcatcgt 3801541 aagcgggtta gaggaaatca tgaaagaaaa aggactgact tcatataagc tgcatggtca 3801601 aacacaagcg gcaggctttt atcaaaaact gggctaccag atttcttcac aggaatttat 3801661 ggaggacggc atccctcacg tcttgatgac aaaagaaata tcgcggaata taacatgaaa 3801721 tatatgtatt acggaatagg catactcata ttaagtttgg gcatttcctt aaccatacaa 3801781 tcaggactgg gcacatcacc cttcgatgcc cttttggttg gtctgtcaaa aaaaatcggt 3801841 cttaccgtag gaagctggga ggtccttatt tctgtgatcc tcttaatctg caacgctata 3801901 ttaacgagaa aaaaacctat tttgctgggc ttgattacag cattcattac tggaataggc 3801961 attgacctat ggttgtttgt tgtaaaaaac accatctatc taaactcgtt gttaagcaaa 3802021 ctgatttgtt ttggaattgg tttggtgctc atcggtcttg gaacagccat ctatcttcag 3802081 acgaaattcg catcaacacc gatcgatcat ttaacactta ttatccgaga tctctccaaa 3802141 agaacaatat tgttttcaag gacattggta tacgctcttt tcttagtatt agccatcatc 3802201 tttaaaggcc ctatcggcat cggaactctt ttaacggttt gtttgggagg aatgctcctt 3802261 cacgttttta tgcctattgt ggaaagacat ttcttatcaa agaatagaag aggttattaa 3802321 gaaacctctt ctcgatccaa aaaacgaaac gcaaaacaag ccccgtttcg ttgtcaattc 3802381 tttatctctg gtactgttga ggttttataa tcaattaaaa tttatagtac caaaaaatcg 3802441 caatttcatt tgctgttgga aagttggaat aaagcatcgt atcaaccgca cctattataa 3802501 agtgatgttt ggcataaaaa tgacaagctg aaatattaat atcttgggtt tcaagcataa 3802561 gaccacaaaa atgattctcc tttgcccact caatcgcttt atgtaataat gctgttccaa 3802621 cacctttttt tctatagtct tttgccacgg caatgtcctc tattagtgca tacccattcc 3802681 agttagaacg gatcttaatc cggccaatgc agttgttttc aagataatat aaaaaagccg 3802741 ctttcccctc ttcttcaaca taactaacat ccatgtcatc atcttcatat tgtttaaaat 3802801 aaggtttaga aaatcgttcc tcagtatatg tccaaacacc gttttcaaaa gcaggtatca 3802861 ttctcccaaa aacaacgaaa ggttcgtttg gtttattgaa atctttcata ttcaaatgag 3802921 tcattttcat gatcatatca atctccgcca atcgagataa tatttagtaa actcgtttcg 3802981 atactattca acaacagctt ccaaaagtgt actctttaag agaacagcat tagataaggc 3803041 atccattacc ttatatattt cactatctta atgaggtatt tcaacagagg cttgtggtac 3803101 agtaaaaagg aatagaaaca agagaaaaga agatgaacct atgcccacta acaataaact 3803161 caatgagaaa tatcatactt ccttcaactc gcccacaacc ctgttgacta gtatccgtgg 3803221 agagaggaag ctttgacaca gcttctgcca ttgatgacat ctctattgaa gtatccaaag 3803281 gacaaccaag gatcgctctt tgactttttc aagaagaaag tagagtgaat aaaggagtga 3803341 ttgagtatgt taacaagaga agatatcttt aaacacgtca aagaaaaata cggtacatcg 3803401 cctgattacc cgtgggagaa atacccaaac tatgcttctt tgagacatac atcaaacaaa 3803461 aaatggtacg gtcttatcat gaatgttctc ccagaaaaat taggcttgga tggtcatggc 3803521 gaaatagata ttctaaatct aaaatgtccc cctgaaataa gtgatcgctt aagaaacggg 3803581 gaaaatatct tacccggata tcatatggat aaggaacatt ggatttcaat tgttttagaa 3803641 cggacagatc cagaaggcga aatctataac ttaatcgagc agagctttca tttaaccaag 3803701 tgaagataaa gagtgttcct gctaatcaag ctgcgaagag tagtgggcac tttcatttta 3803761 ggatactgtt cttcactctg tccacaaacg caacttagtt catctggtgc gagagtggga 3803821 gaagaatttc aaccaacttc ttatgtaaaa ggatgaatag ttatgacaaa taacttaaaa 3803881 cagagaagaa tcattttaga tttagcagtt actttagatg gttttattga agggaaaaat 3803941 ggagaagttg attggtgtat tatggaccct gatatggggt ttactgattt tttaaatcaa 3804001 attgatacta ttttatatgg tagaaaaagc ttcgatttat ggggacaata cattccaaaa 3804061 aatgaagacc ctgatacaga aaaggaactt tggaaattgg ttcatagtaa aaagaaatat 3804121 gttttttcca gaacacaaaa tgagattgat aatcaagcca tatttataaa tgataatatt 3804181 cttgaagaag taaataaatt gaagaaaaat cctggtaaag acatctggct atatggtgga 3804241 gcgagtctca ttacaacttt tataaatttg gggcttgttg atgaatttag attatctatt 3804301 caccctgttg ttttgggaga aggaaaaccg ttgtttattg atgtaaaaca gaggataaat 3804361 ttaaaaatgg tgaatacaag aacattttcc tctggcgttg tgcaaatcgt ttatcattgg 3804421 aatggctaac attgtaaagt aacactcgac agtaatcctt cttattgaac taaaggggaa 3804481 tccataaata atgggttccc cttaatatac tatggaatta tcaatatcaa attttctgta 3804541 ataaaagagg attgaaaagg acgatgtctc ctcaattaac atcattaagc attatagtat 3804601 attttcttct ccctctttta agtaatcggc taagttttgt atttataaaa aaacgaaaga 3804661 aggtgatcca atgcctacta acaataaacc caatagatta atcgctgaga aatctactta 3804721 ttttacttca acatgctcat aaccctgtgg actggttccc ttggggagaa gaagcatatg 3804781 aaaaagcgaa acgcgaaaac aagcctgttc tcgtatctat tgggtatagc taacgatggc 3804841 taatctaaag aacatgctat tgatgccatg tttattcatt ttacaaaaaa ggatcaacct 3804901 tgaattactt tcacaagatt gatcctttca ctcatttagc catgtctccg cgaacgttta 3804961 tatacattca agattactag ccaacaaata acaatgattc ctgcaaaaag tatgagcata 3805021 ttgctataca aataggtaga gtgatcaacg tcaataggca gcagcctatg atctaggaag 3805081 ccgatagata ataaaccgcc tacaatcgca atacccgttc cctctgataa aaagctcgtg 3805141 aaattaagca aactcattcc agcgcccgct tccttttctt tcaaactgct agacacaact 3805201 gtagatataa ctgtttttgt gaaagatagc cccccaaaaa caaaaattac tataattgtc 3805261 atgatccatg gtgctgcatc tataaaaaag gcagcgatta aaaagccgga agaaagcaat 3805321 gcacttccaa tagttagtac atacaaggaa cctttccgat caacaagcaa tcccccaatg 3805381 taaccaaaga tgatgacact cattgttccg gggaaaataa tgccgcttcc aattgctgca 3805441 gtacttaaat ggtgaacatc tttcatcatg taaggaacca tagagacaaa tcctgctact 3805501 gtaccaaata ttagtcctcc gcaaagggtt ccaatcacaa aaaagacgtt tttccctaat 3805561 tcagggtcaa caaaagggtc ctgagctttc ctaatgtgtt gcacaaatat gaagaaagca 3805621 aggatactga tgatcagaaa agaaaatcta taagatgttg taaacagcat aaaaaatacg 3805681 atacctgcag acatcaatat aatccctgcc atatcaatgt gtcctcttat tctctcttcc 3805741 tttttcaaca attttataag gaatggaacg gtgataattg ttgcagttgg aataagcagc 3805801 aaatacgacc aatggatata atgagcaacc attccgccaa tagctggccc aacaccttct 3805861 cccattgcta ccagggaccc gatcaggcca aatgctttcc ccctgttctc ttttggaata 3805921 tagcgcgcaa cgacaaccat cacaagagct gggaatgcgg ctgcaccaat tccttgaata 3805981 aatcgggcta gaatgagaat aggaaagaaa gagtgtccaa caaatccaat gatcgaccct 3806041 aagccattta ccataatccc aaatagaagc agatttttga tgcccagctg gtctgatagc 3806101 tttccatata gagctgttcc aatggagaag gttaacataa aggctgtatt cacccagttt 3806161 gcacttgctg gcagtttatt aaactcgttg gcaatatcag gtaatgagac gttcagaacc 3806221 atttcattta atacgctgaa aaatgataga acacaaagcc aaatcaaaac ttgattgtgc 3806281 cgtaaagttg actgtgaata agacgtattc acaatttccc ctccattaat gagggcagac 3806341 gcagtttata gggtcattga tacgcttccc tcttttaatt gtaccctgtt cattttattg 3806401 cacttcataa taactccccc tacatttgat tgatatgatc ttattatata tagactaagg 3806461 attaaacttt tacttttttt ataaaaattt gaccagattg cgaaacaagg aaaaacgtta 3806521 ttcgcattta tctcaagtgg caaaatgaaa cattagttta tattttcaca tcacaattat 3806581 cgataagcag tcagttattg tatttgttta ggataactgt ggtaacctga atataaccaa 3806641 cttaggaaga aggtgatccc atgccaaata aaagtaaacc caatagatta atcgctgaaa 3806701 agtctcctta tttactccaa cacgcccaca accctgtgga ctggttcccg tggggagaag 3806761 aagcatttgc aaaagcaaaa cgcgaaaaca agccggttct ggtcagcatc ggttattcga 3806821 cgacttgtca ttggtggcct gggataatca aatcgtgtgg aactccatta aaagataaca 3806881 gaagccattt taaacgataa tactatttgt tcaaacaata cagtctacct tttatttcat 3806941 tcattttcta aaacctgtaa tccgtaacca cgcggtagca ggttttttta tttgcttgac 3807001 ttagagttaa ctctaaattg taaactaact ttaattaaat gagagggatg atgttgttgt 3807061 attccattag taaagctgct gagaagacta gtattagttc gtatacatta agatattacg 3807121 aaaagattgg gttacttcca ccaccaaaac gaaaaaacag tggaaggcgt ttttatacgg 3807181 agactgatat tcagttcatg ttattcctga aaagtttaaa ggaaacaggt atgtctttgg 3807241 aggatattaa tgagtttgtc aaagacggat gcattttgga aaaaatcaat tcggatgtta 3807301 aatcggcaca actctcccca tctataaata aacgtattga gattttaacc aagcacttag 3807361 agaaaatgga aattaaaaaa agggagctgg aagaagtgat ttctactaca aaaggaaaac 3807421 tggatacata ttattcaatt ttgaaagagg aagtggaaaa caaatgaaac atttaaatat 3807481 atacataatg ttacttggct tctctatttt cacgggagct acttttaatc ttgcaaaata 3807541 tacagttgga tatttttctc catcgtcttc tgcggcatgg cgtttcggtt tagcggctgc 3807601 agtgatgctc atcattttga tttttactga aggtataaag aagagtcaat tacggaaaaa 3807661 cgccgtttca tacattgttc ttggaattat aggaatcttt ggatttaatg ccttgttttt 3807721 tgttggttta aaatatacat ctcccgttaa cggagcatta ataatggggc tgaatccttt 3807781 attaacagca attctcgctc gaattatctt aaaggacaac atgacaaaaa aacaagtact 3807841 cggcatattc tttgcattca tcggtgtatt gttagtcatt acacaaggtt ctatcgaaac 3807901 cattaaaacc ttatcaattt caggaggaga cttaataatc tttacaggta acgtttgttg 3807961 ggcactttat ggcgtacttg gacgtcggtt tgtaaaggat ggtacaccgc tatctacaac 3808021 cacttatacg atggttattg gtgctgttag tttaatagta gtttccttat ttacatccaa 3808081 acctgtttct ttatcgaaca tcccgattgg agtttggggg gcaattgctt ttatggcttt 3808141 ttttacaagt gttttgggtt acctatggtg gaatcagggg attaaagaga ttggagctag 3808201 taaaacatct ttatttttca accttgttcc cgttgtaacg atgattattt catttgccgt 3808261 tggaacacca ataaaggtat ttcaagttat tggggctgtg ctagttatat taggcgtttt 3808321 aaccgcttcg ggggtaatac gtattcctaa gtacaatact aaagaacagt cagctatata 3808381 aagaaatagg gagtattttt gagaaaatgt gttaagttaa atatacacta attataggaa 3808441 gaaggtgatc ccatgccaaa caaaagtaaa cccaatagat taatcaatga gaaatcacca 3808501 tatttactcc aacacgccca caaccctgtg gactggttcc cgtggggaga agaagctttt 3808561 gaaaaagcaa aacgcgaaaa caagccggtt ctggtcagca tcggttattc gacttgtcat 3808621 tggtgccacg tgatggccca cgaaagcttt gaagacgaag aaatcgcgcg tcttctcaat 3808681 gaacggtttg tggcgattaa agtcgaccgg gaagagcggc ctgatgtgga ttctgtttat 3808741 atgagaatct gccagctgat gaccgggcag ggcggctggc cgctgaatgt gtttatcacg 3808801 cctgatcaaa agccgtttta cgcgggtaca tattttccaa agacgagcaa attcaatcgt 3808861 cccggttttg ttgatgtgct tgagcatctg tctgagacgt ttgcgaacga ccgcgagcat 3808921 gtcgaggata ttgcggagaa cgccgctaaa catttgcaga ccaaaacagc tgcaaaaact 3808981 ggtgagggcc ttagcgaatc agcgattcac cggacattcc agcagcttgc cagcgggttt 3809041 gacacgatct acggcggttt cgggcaggca ccgaaatttc caatgcctca tatgctgatg 3809101 tatttgctac gttatgatca caatacaggg caggagaacg ctctatacaa cgtgacgaaa 3809161 acattggaca gcatggcgaa tggcggcatt tacgatcata tcggctatgg gttcgcccgc 3809221 tattcgaccg atgacgagtg gctcgttccc cactttgaaa aaatgctgta cgacaatgcg 3809281 ctgctgctga ccgcttatac agaagcctat caggtcacgc aaaacagccg ctataaagag 3809341 atttgtgagc agatcattac gttcattcag agggaaatga ctcatgaaga cggaagcttt 3809401 ttctcggctt tggacgcgga cacagaagga gaagaaggaa agtactacgt gtggtcaaag 3809461 gaagagattc taaaaacgct cggggacgat ctcggaacgc tgtattgcca agtgtatgac 3809521 atcactgaag aaggaaactt tgaaggcaaa aatattccta acctcattca cacaaagcga 3809581 gaacaaatca aagaggatgc cgggttaacc gaaaaagagc tcagtctcaa actcgaagac 3809641 gcaagacagc agctcttgaa gacacgcgag gaaagaacct atccgcatgt cgatgataaa 3809701 gtgcttacct catggaacgc gctgatgatc gcgggtcttg cgaaagcggc aaaggtatac 3809761 caggagccga aatatctcag cctagcgaaa gacgccatca catttattga aaacaaatta 3809821 atcatcgacg gccgtgtgat ggtccgatat cgtgatggcg aagtgaaaaa caaaggcttt 3809881 atcgacgatt acgcttttct cctatgggct tatctggatc tctatgaagc ttcgtttgat 3809941 ctttcttatt tacaaaaagc gaagaaactg acagacgata tgatcagctt attttgggat 3810001 gaggagcatg gcggattcta cttcaccgga cacgatgcag aagccttaat cgtacgggaa 3810061 aaagaagtgt acgacggcgc cgtgccttca ggaaacagtg tggcagctgt tcagctgctg 3810121 cgtctcgggc aagtcacagg cgacttatca ctgatcgaaa aagcggaaac aatgttttcc 3810181 gtgttcaagc cagacataga agcgtatccg agcggccatg ctttctttat gcaaagtgtg 3810241 ttaaggcatc tgatgcctaa aaaagaaatc gtgatttttg gcagcgcaga cgatccagcc 3810301 agaaaacaaa ttatagcgga gcttcaaaaa gcctttaagc ccaacgactc cattctggtg 3810361 gcagagcagc ccgagcaatg caaagacatt gcgccatttg cagcagacta ccgcatcata 3810421 gacggcaaaa caaccgttta tatttgtgaa aacttcgcct gccagcaacc gacaacaaat 3810481 attgaagaag cgatccacac attaataagc agcagggatt aagacccttg ctgcttactt 3810541 tttgatttct tatggtacca taaagcgatc cccgcaaaca caaggttgac cgctatcgta 3810601 aagaaagcct cccacatcgg gttcccccgc gtaacggtaa acagagaagg aattcctcca 3810661 tacacactgt ttttttctgt aataaacata cacaaaaaca tattattcgc ggcatgggcg 3810721 ccaagtgata tttcgatgct cccagtttta atcgtgtaat acgtccacac aaacccaaat 3810781 gttaagtact caattcctgc ccagacagcg ccattgttca tttctggatt cgcaaaatgc 3810841 aatacgccaa acaatcctcc gacaatcagt gtcaaaaata gaggattttt cgtcaatctc 3810901 ccgaaagctt gaagcaaaaa tcccctgaaa aatagttcct cagctgatgt ctgaatcgga 3810961 accaaaatga gggcagccgc tagcagccag ataaatcgtg atgcattaaa ctcttgcatt 3811021 gaatagctat caggatgaat cacaaaatca atcaattgta cggcgatcat tagcaagaaa 3811081 taagcaataa aaccaaagga aattctccgc caattcatct ttgaatttgg tgttatcacc 3811141 gttcggaaag gccgcttcaa aataaagcgc acagccagcc aaactcccgg aatggcgaat 3811201 aaataaatca catgggacaa ataaagatct acgaggggat cactcagcac agcttcatcc 3811261 aaatcaaacg tgatattggg attcacaata accgtgaaca atatagcgaa aaggtaagct 3811321 atattcccta atacatataa ccctaccatc accaaaaaag cgaaaaaata tctccacaac 3811381 gtattgtttc cttctatagg acggataaat gaattcattc cttctatgtc tcttcctttc 3811441 aatgagaata ttactatata tttgcataaa ttggtctatg aatctactgt tttggaaatc 3811501 ttttaagcaa aattaaaata taaagtgtga atttagttct tccatctagt gatttgaact 3811561 ctgttgccaa tgaaccaaga tacttataat agtcccaaga ggggaatttt cagtcttttc 3811621 tactactcaa aagggggttt tttatgaata cgatcttcaa acaaaagaat acacatcctt 3811681 tctcaaacgc agcgaatcgt ttagaccgcc ttccgatttc acgcgttcat ttccaagtgt 3811741 taaccgctct cggcattgtt tatttctttg atctcgcaga tttatttacc ctcagcaacg 3811801 tagcgccggc actgatcgag cattggggca tcccgctttc aactattgct aacgtaacgg 3811861 ccgcttcgtt tttaggcatg tttttaggcg cttcactggg cggacggctg tccgatcgaa 3811921 tcggccgcaa aaaagcctta aatctatttg tctttgtttt ctcaatcgca tcgctatgca 3811981 atgctgcggc atgggacatt ccatctttaa tgacattccg tttcctcacc ggatttggcg 3812041 ttgcagccgc catggtcatt acgaatagct atttggcgga atttttccct tcaagtgtac 3812101 gtggaaaata tatttctttt tgtgccatga ttggattgat tggggttccg atcaccaaca 3812161 ttgtgtctgc ctttgtcatt cctcttggtt catggggatg gaggctagta tttgtatggg 3812221 gtgccgtcgg ccttatttat tttttcttca tccaccgtct ggaagagtca cctcgctggc 3812281 acgaaaatcg cggggaatat gcgaaagccg atgcgatcct cacccgaatt gaagaacagg 3812341 ttgaaaagga gaaaggcccg cttccggcag catcccagcc taaagtaagc gaaactgtta 3812401 agcagaatgc aggttacgca ggcttattga aaggcagaaa cctcaaaatt accatcgtat 3812461 tatctgctgt atggattttt gaaacgtttg ggttttacgg atttgcttca tgggttccaa 3812521 gcctgctaaa aagcaatggc gtaaccatgg aaaatacatt atggtataac gtattgcatt 3812581 ccgtcggcgc tccacttggc gcactgctcg gctccatgat ttccgaaaga tttcaaagaa 3812641 aatggatttt agctgcgagt gcgtttctga cggccatcgc cgggctctta tatggtatga 3812701 cttttattcc catcatgatc attgtatttg gttttatcgt gaatatcaca gaacgggtct 3812761 ttacctcgaa cttatacgcc tatacatctg aaccttatcc gactgaatac cgctcgtctg 3812821 gcagcggttt agcctatggt cttggccgtt tttcaaacat ttttggctca ttgcttgtcg 3812881 gatttattgc cgttcagctc ggctatatca gcgtcttctt atttattggg ggctgttggc 3812941 tcgcatgctc cttgctgtta atcttcttcg gtcctaatac gaatgcaaaa cagatttaaa 3813001 aaagtcagtg cggatctgcc gcactgatct cattacaatt gcttcaaaat ccttgcgggg 3813061 tttccgccta caacagtatt agcgggtaca tccttagtga caacagatcc agaagcaatc 3813121 actgcgttat caccgattgt cactcccggg ttaatcaccg cccggcctcc aatccaaact 3813181 tgatctccaa ttgtcacagg cttaccgaac tccttcccgg atttcctttc gatcggatca 3813241 agaggatgac cggccgtgta gatatgtaca cctggcgcaa tcaaacaatg acagccgata 3813301 cgcacctcac acacatctaa aatgacacag tcaaaattaa caaatgtatg atctccgata 3813361 tgaatgtgat agccataatc acagcggaat gtcggcaaaa tcgtgacttg atccccaacc 3813421 gaaccgagca gctccttcaa aagcttcgtc cgcactgcat catcttccgg tgtttcgttg 3813481 tattgtctaa tcagctgtct cgcatgcttg cgttctagta atagttgttg atcttccgaa 3813541 ttgtataatt ctccggctgc cattttttct ttttctgtcc tcagcattta agtcactcca 3813601 gatgtcagat tgtaatctcg atcaaatttc cttcatcatc ctcaatcacg ctttcatagt 3813661 agccgtctcc tgttgtcctc gggccgttta ctactgcgaa accatccgcc ttcaatcgat 3813721 cagtcagttc gtcaactttc tcccggctcc caacggaaaa ggcaatatgt gcccagcctg 3813781 tcattgtttg tgagggcgga tcggtcacat tccctttttt cataatttcc agccttgctc 3813841 cggaatcaaa cgtaataaaa taagacttaa aatctttttt ctcattatga tacaaatcat 3813901 tcgcttcgcc attaaaatac gattcataaa aagacttcat tcgctctaaa tcattgaccc 3813961 agaccgctgt atgttcaatc tgcatttctt cctcctcctt cgccttcaat gaagttataa 3814021 ggtatgaaat gcatttcagt tcaagctttt ttcttaaatt tatgctgaat tttgatatca 3814081 gcgggttcat cctgcaaaaa tagagaaaat gctgcgatgc cgagctgctc aagattcaaa 3814141 tcaagcgacg gaaaaccaag aacacggctg atagaagtat ttccctcgcc tatgatttca 3814201 acatcccaat tattcttttt ggcaaataga tgaattccag ctgccacttc atcactattt 3814261 gcataaatag cagtcggaac ccgcccgctc atataaaaat gttcagctgc cagctcacca 3814321 tcattcatat cgttgcatcc ggacagcata tggcggtctt ccaaccttcc gcagacagct 3814381 ttataggccg cagctttatc agccgtgctc gggctcctat cagcttctct gacacacgta 3814441 aaagcaatat tctcatgccc gcggctcttt aaatagcgaa agctctctgc ataagcagtt 3814501 tttctgtcat taaaagcaca agggacatca atgtctccgg tatcctcaca agcgatgacc 3814561 ggcccatatt cctgataagc taaaatgctg tcccaatgat tggcgcggga agtaatgatg 3814621 agaccgtcta ttttcttcgt tcttaacagc tctaaatatt tgatttcaat atcggggtta 3814681 taattggtgg ggagaagggt cgttgcatac tcatgctgaa aagccgcctt ggtgattccg 3814741 ttaacgattt tatcaaagca gggatgatcg ctataaggca gaatcacacc gaccgtatgg 3814801 gttttcccgc gaatgagatc gattgcggtt cgatttggtg tataatccaa ttccttcatg 3814861 acttgatgaa caagctttct cttttcttca gatacatacg gatgatgatt caatacacgc 3814921 gagacagtcg aaacagatac atttgccagt cttgcgatct cttttatatt tgccatctct 3814981 ttctcctttt catataaaaa aagcagtaag tgtaaaatcc ttactgctat ctcatcatat 3815041 attgatgata agttcaacag gacaatggtc ggaacccatg acgtccgctg atatgctggc 3815101 atcttcaatc tgttccttaa ggctttcaga aacaacaaaa taatcaatcc gccatccaat 3815161 atttctgtcc cgggcgccgg cacgatacga ccaccaggaa taagcgcctt caagatcagg 3815221 ataaacatga cgaaaagaat caacaaagcc agcttctaag aaacgagtga atgcctctct 3815281 ttcttgatct gaaaatccag cgttattccg gttcgccttt ggatttttca agtcaatctc 3815341 ctgatgggct acattcaaat caccgcataa aatcactggt tttttctgat ccaattcaag 3815401 aatataagac agtaaagcct cttcccattg catgcggtaa tcaatccgct ctaatcccct 3815461 tctggaattg ggcgtgtaaa cagtcatcac aaacacgttt tcaaattcca gcgtaatcac 3815521 tctgccttct tggtcatgct cttctactcc gataccgtag atgacctgca gcggttcttg 3815581 cttagaaaaa acagctgtgc cggaatatcc ttttttcact gcataattcc agtacacatg 3815641 atagtcttca ggctggagat caacctggcc gtcctgtatc ttcgtttcct gaagacatat 3815701 aatatctgca tcctcttctt tcaaataaga gaggaaatcc atttttctca tcacagcccg 3815761 caggccgttt acattccatg aaatcaactt catgtttcat cctcccccct ataaaaaaga 3815821 gcaagaaccc gaaggtcctt gctctttaca tatcagctta ctcaccgctt acgtatggaa 3815881 gtaaagccat ttgacgtgcg cgtttgatcg ctgcagtcaa tttacgttgg tatttagcgt 3815941 ttgttccagt tacacgacgt ggtaaaattt taccgcgctc agaaacaaac tttttaagaa 3816001 gatctacatc tttgtagtcg atgtgcgtga taccgttaga agtgaaataa cacactttac 3816061 ggcgtttcgc acgaccgcct ctgcgtcctc ctgccattgt catttccctc ctttcttttt 3816121 cattttaggc gataatcaca ttagaatgga agatcatcat ccgagatgtc aatcggtttg 3816181 ccgtcgttgg caaatgggtc atcattaaag ctgttcccct gattgcgtct ctggttgttt 3816241 tgatttcccc caaatggatt atcattttgg cctccgccaa agtactggcc tccgccgctg 3816301 tttccttcgt tgtatccacc tgaaccagaa ccgccgccgt ttttcggctc aagaaattga 3816361 acactttcag cttggacctc tgtcacgaag acacgctgtc cttgctggtt ttcatagttt 3816421 cttgtttgta aacggccatc tacgcctgca aggcttcctt ttttcaagaa gtttgcaacg 3816481 ttttcggctt gtcttctcca agtgacacaa ttaatgaaat cggcctcacg ttctccggac 3816541 tggttcgtaa atgtacgatt cacagcaaga gtaaacgtag caacagccgc accgtttggc 3816601 gtataacgaa gctctgggtc ttttgtcagt cttccgacta atacaactcg gttaagcata 3816661 agaaagacca ccttttacca ttatatattt caaaattgct tattcttctt ctttaacaac 3816721 aatgtggcga atgatatcgt cactgatctt agctagacgg tcaaattctt gaactgccgc 3816781 agcgtcagat tgaacgttta cgatttggta gaaaccgtcg cggaaatcgt tgatttcgta 3816841 agcaagacga cgtttacccc aatcctttgt tccagtgatc tccgcaccgt tagaagtcag 3816901 aacgttgttg aaacgctcga taactgcttt tttagactct tcgtcaatgt ttgggcggat 3816961 aatgtacata acttcgtact ttctcatctg tttgcacctc cttttggact aagcggccca 3817021 taatgggcaa ggagcaataa ttctattact cacaatttta tattatacca aagctcttgt 3817081 ccctttacaa ctgcatccta tacattaaat cggaaatgaa taacatctcc gtcttggacc 3817141 acatattctt tcccttcaag gcggactttt cctgcctctt tagctcctgc cataccgccg 3817201 cccgcaagaa gatcctcata agcaactgtc tcagcacgaa tgaagccccg ctcaaagtca 3817261 ctatgaataa ttcctgcaca ctcaggggct ttcatgcctt ttttgaatgt ccaagctctg 3817321 acttcctgtt ctccggctgt gaaatatgtt gcgaggccga gaagagagta agacgctttg 3817381 atcagctgat caagacctga ttcttgaatg cccagctctt ccaagaacat ttgcttttct 3817441 tcgccttcaa gctcagcgat ttcagattcg atttttgcac acacaacgat aacttctgcg 3817501 ttttcgccgg cagcgtactc gcgaatcttc gctacatttt cattgccaga tggatcagca 3817561 acttcatctt cacttacgtt ggccacgtac aaaataggct tcgaagtcag taaatggagc 3817621 tgcttcacaa gcttttgctg ctcttcagtg aattctacag atcgagcagg cttttcactc 3817681 tcaaacgctt ctttcagttt agataaaatc tcaaactcaa atacagcgtc tttatctttt 3817741 tgcttcgcaa gcttgctgac gcgtgtaatc cgcttttcaa ctgtttccat atcagcgagg 3817801 atcagctcaa ggttgatcgt ttcaatgtca tcaatcggat caacctttcc ggaaacgtgt 3817861 gtaatgttgt catcggaaaa agcacggaca acgtggcaaa tcgcgtcaac ttggcgaata 3817921 tgagatagga acttgttgcc gagtccttct cctttagatg cgccctttac aatccctgca 3817981 atatcagtga attcaaaagc agtcggcaca gtcttcttcg ggttgaccag ctcagtcagc 3818041 ttttgcagac gatcatccgg cacctctaca attcccacgt tcggatcaat tgtacagaac 3818101 gggtagttgg ctgattcggc accggcctgt gtaattgcgt taaatagtgt tgattttccg 3818161 acgttcggca aaccaacaat tccagctgtt aaagccattc tttcatctcc tctatataaa 3818221 accgtcattg tatgaacgta ttttgaacct agagcaatta taaggaggtt cactggaaaa 3818281 gacaagctga caaaaaagca ttttcagctt gccaatccct ttgattatgc ttttttcaag 3818341 cctactaaac agtcaaaaag cgtacttccc attccattat cagaatttgt atcatttgtc 3818401 agtgcattga ctgaccctcc aaaagccgcc cacatgcctt catctatatt aatcgtcttc 3818461 gcatgagcct gcttcatcac tttcaccttg cccttcatgc ttccgcggtc attaaagatg 3818521 acaacttcgt ctccatcctg aagatcctgc ccagccgcta tatctggaga aatatcgacc 3818581 tgaacgtgct gaagcttttc aataaacggc acatgctgtg aatgattgga acgctgcgga 3818641 tgaatggata agagcgtata agggtacttt ccagctaact cctcattatg gaaaacagat 3818701 tcttcgggca catttaattg aagcgagccg ctaaatcctt tttgctcagc tagcgacgaa 3818761 gtaaattcaa attttccact cggcgtcaaa aactgataat catcccacgg cacctgtttt 3818821 actggaagag ggaggtggcc tttttctttt aaacgctcaa gtgtcacatc ctctgcttcc 3818881 aatgaagaaa gccccatctc taaaaattct tgagtgctgt attcaaacag ctcgccaaac 3818941 ccaagacgtt ttgcaagctc tgaccagatc cagctgtccg atttcgcttc accctgcggc 3819001 tccacaagct tcttcccgta ctgaacataa tgatgataca tactggaata gtagatatct 3819061 tcttcttcaa aaacagtggc agtcggcaaa acataatcac acagctctgc ggtatccgtc 3819121 ataatggaat caatcgcgac cgtcattgga accttttcaa atgcttgtct caccttattt 3819181 gtattcggca cctgagtcag cggatttccg cacgtcacaa taatcatctc aatcgcagga 3819241 tcagcagcgg tcaacacttc ttcagcctgt gtcatcattg aaaaagaacg ggatgttgtt 3819301 tttaattccg gcagcgtcag ctttgttttt gcaaagctct caccaatctg gacatttccg 3819361 aaattcgcgc cgccgccctt aattccgaca tttccgcttg ccgccacaag tgcatcaatc 3819421 caacgaatcg ttcccccgcc gtttttatat cgctgcatgc caagccccat aaaagtagac 3819481 accggaccat cagcatacaa acctgccaaa tactccagct cctccataga agtttctgtt 3819541 ttcacaataa actcttccag agaaacggtc ttcaaaagct ctttcacatc atcaaaaccg 3819601 acagaatgct cagaaataaa cgtttcatcc gttcttccca tctcaatcag aaccttcaaa 3819661 acggctgccg caagccagcc gtccattcca ggctttacag agatatagcg gtcggcaagc 3819721 ttagcagtcg ggttgaagat cggatcaatc accgtaatcg tggcgccctt ctttttcacc 3819781 tgctgcaagt gatggtataa gtgcatattt gttcttgata catttcttcc ccacacaaca 3819841 acatgcttgc tgttgtaaat atcaagcggt ccgtgaccgt acgaacggcc aaaatcccag 3819901 ctttgcgcct cgataccgga gccccagcat atgcttccga cgatttcggt cacgccgcca 3819961 tatccattaa aaaaacgctg atcaagcgct tttaacagac cgttattcgc ataatcatgg 3820021 ctgtgcaaaa cagcagtcgt ctccgacgtt tccttgattt cccgaagttt atcggcaatt 3820081 tcatcaagtg cctgctccca agaaatccgc acaaactcgc cattttgttt tttcattgga 3820141 tagcgaagcc gatcaggcga atttgttttt gtctcaagca ttctgccgcg gccgcagatt 3820201 ttaccttccg taatcggatg gtttggatct ccgtccactt ttgttacctt tccatcatca 3820261 acagtcacca aaaagccgca gctgtcccaa caattcagcg gacatgccga ctgatgcact 3820321 ttgctcatcg ccgtcttctc cttaccttct atatgaaaaa gcatgagtgt cggcctattt 3820381 atgaagtagg ctcctcatgc ttgactagta ctttttttag ttttctttca aattctcttc 3820441 tcggaatcat aacactgtga gagcatccct cacacttaat tcgaatatcc attcccatgc 3820501 gtataatttt ccagctgttc gctccgcatg gatgcggttt tttcatttct acgatatcat 3820561 tcaggccaaa gtctttatcc gccaagaccc ttcacctctt ttcctaaact gctgtatcta 3820621 ttgtacaaaa aaactgatca taagagcaat caagataccc gaaaagaaat acatcctctt 3820681 atttccattt actcaaaata ggatataaga gcagacaaac taacaaatac aaattgagca 3820741 tcccatatat cggatacaag aacgcgatca aatcagaaaa tccgaaagaa gtaaaaggta 3820801 ccattaacac taacaaaatc aacacaatca tccatctcgg catatgaata aacgccatca 3820861 gccggctgga caaacccagc aaaccagcta ccgtcgtcgt gtaaatcgcc aggcacagca 3820921 ccgccgtcat acataaaaaa aggaaataag gcgcaccctc cagaacggca aacagcggta 3820981 tttcaaactg agaaagggag cccgccagct ccaccaacgt ttcattataa acaaatgaga 3821041 tcacgccaaa aataagaccg cttgccacac ttgcgatttt tgcttctccg agccctttca 3821101 tctctttccc aacagaggat aaaatcgcaa caactgaaag gatgtttaaa gaggtaaacg 3821161 taatgctcgc aggccagtta tactgctggg acaaatcaat cgtccacgta tggtgatgtg 3821221 tgctctgaaa ggagatcagc gcatataaaa gccccgctac taacacagga atcaaaatac 3821281 tatttataga taatattcct ttcacatccc acaaaaacaa gcacactgtc acgatgcaaa 3821341 tcagcgtgat tccccaccag aaaggaagct tgtacatttg cagggtcaca ccgcctccgg 3821401 caatcatcac catagtcgtc gaaaacaaat aaaaaatgat gaggacatca taaattttcg 3821461 ccagccatgg ccccattaaa tgctccagaa ccggcagaaa atgagtggat tgaaccttaa 3821521 aactgatttt catcacaata taagacgaga aaatgaacat aattgtaaac agcacaatag 3821581 caagtccgct ttccgcccca aaaaactgcc atatctcctg accgctcgca tatccggccc 3821641 cgatcaggct ccctaatatg agcagcatcc acttcattcc ggctctccac aacactatca 3821701 cctcatagac aaagttcagc ttgttcccgt tattgttact atataaataa aggaaagcaa 3821761 acatgccata ttttcataga catttgaaca caagctgaaa ttatcatacg aaatacacat 3821821 aaaaaagact gctaatacgg cagtctaaaa agagatattt atttgtttgt ccgcggaatg 3821881 aagaagtgaa cttcactctt cacttttttc taaccattcc tacctattca agtgtttcat 3821941 aagcagacca ttgcttgatc atgatcgagg caatggggga caatacttgt aatcgcccac 3822001 taaccattca tatcatgccc tctacttttt taaaatctct ggtgccatac acaaagcata 3822061 aaaaatcata ctgctggata tactgtaaac aaccttacat aactacacac accatagcaa 3822121 ttctgttacc tactataaca aggaagtgaa acccatgaat cgaaaaggcg ggcttttttc 3822181 ttctcaggaa cgagtaaagc aatatgtttc acatacagat gctgcagcgg caaaacaaat 3822241 ccaaaccatc ctttcttcat ccttacgtaa agctgctggc aaaccaattg tcgtggtttg 3822301 tatcggaaca gaccgttcaa ccggtgactc attaggcccg ctcgtaggaa tgaaactcaa 3822361 acagatgcag ctcaccagat tccatgtcta cggaacctta tctgaccccg tccatgctgt 3822421 gaacatgaag gataaaatca atgacattca taaattacat aaaaacccat ttgttatagc 3822481 agtcgatgca tgcttaggcc gcgttaagag tgtgggttca tttcaaatcg gggacgggcc 3822541 attaaagccc ggagccggtg tacaaaaaga ccttcctgaa gtgggagatc ttcatattaa 3822601 cggaatcgtg aatgtgagcg gttttatgga atattttgta ttgcaaaata ctagactcaa 3822661 cttggtcatg aatatggcaa atgttctagc ggaaggtttg agtttaacag atcggacaga 3822721 gtggaggcaa gaacgcctta acccgttgca aaggctcact gggcgcatat aaaataaaaa 3822781 ccatcttcgt ttgaaagatg gttttttcat ttatgattct cgttcagaca aaagctctaa 3822841 aatccggtca aggtcttcat tagagaaaaa ttcaatttcg attttgcctt ttttcttctg 3822901 tcttttaata ttaactgttg ttccaaaata attttggaga taggattccc gttcttttag 3822961 aaccgcatct ttcacaggtt cttttttctt tgtttcacgt ggaacattct gattcaactg 3823021 ctgaatcagc tgctcaagtt ggcgaacatt gagctgctcc gcaatcactt tttgtaccag 3823081 cggttcaagc ttatttttgt tttttaagcc aagaagcgtg cgtccatgtc ccatagaaag 3823141 cgtgccttcg gcaataagct gttgaatatt ttctggcagt gtcagcagtc ttaaatgatt 3823201 cgcaatatgc ggtctgcttt tcccaagacg tttggcaagc tgctcttgtg tgagatctaa 3823261 gtgtttcaaa agggagtcat atgcctgagc ctcttcaagc ggagataaat cttcacgctg 3823321 aaggttttct aataaagcaa tttccctcat taacgcctct gataattcac ggacaatggc 3823381 cggaactgta tctaaacctg ccagctttgc cgctcgaaaa cgccgttcac ccgcaacaat 3823441 atcatagcct tttaaagatt ttctgacgat aagcggctga agaatgccat gctgcagcac 3823501 agattctttt agttcagcta atgcctcgtc atcaaagtgt tttcttggct gataaggatt 3823561 agggcgtaaa tcggcaattt taatttcttc aactgtctct tcagacaaat ctacctgatt 3823621 aaataacgca ttaatccctt ttccaaggcc tttagccatt cgcagccact tcctttgcta 3823681 aatctaaata tacttccgca cctcttgacc gcggatcgta taaaatgatg ggttttccgt 3823741 gactcggtgc ctcactcaga cggacattac gcggaataac tgtcttatat actttatccc 3823801 taaaatactt tttaacctct tcaatcactt gaatgccaag gtttgtccgg gcatcaagca 3823861 ttgtcagcaa tacaccttca atcattaaat cagtattcaa atgcttttgc acaagacgta 3823921 ctgtatttaa taactggctg agaccctcca aggcataata ttcgcactgt acaggaatca 3823981 caacggaatc cgaggcagta agggcattaa tcgtcagcaa gcccaatgac ggcggacaat 3824041 caatgataat ataatcataa ttttgcttta ctgcttcaag cgctctcttc aatctcactt 3824101 ctcttgatat tgtaggaacc agctcgatct cagcccctgc aagctgaatc gtcgcaggaa 3824161 tcacatccaa gttctctact gtcgttgctt taataatatc tattacatct gcatcatcta 3824221 ctaaaatatc gtacacacac tgctctacat cggctttttc aatccctaat ccgcttgtcg 3824281 catttccctg cggatcaata tctaccagca gaaccctttt ccctatgtaa gccaaacatg 3824341 ccccaaggtt gacagacgtc gttgttttgc cgaccccgcc tttttggttc gtaattgcta 3824401 tgatttttcc cacgatgtca cctactttca catgaacatg tactatcttg cttctattct 3824461 atcaaaaaaa gattaaagcg tttcattttt ttcatcattt tgttccgaat cagaagggaa 3824521 ataattgaaa attcaagcac gctttatgct ttctcttata aattctgcaa tttctatgtt 3824581 tttttgactt aaaaaaggaa tttcttaaag aaaaaaagaa gaagtcacag tacagaacgt 3824641 ggaaacagga tggtgagaaa atggtttatc aaacgaagag agatgtaccc gttacgctga 3824701 tgattgtgtt tctcatatta ctgatacaag cagatgccat tgttcctttt gtgctgggaa 3824761 atatgagagt ttccggctgg atcattttta ttctgctgac tcttttaaat ggactcatca 3824821 tttggagctt tattgaccta aaatatgtat tgaaggaaca ccatctgatc attaaagccg 3824881 gattgatcaa acatcaaatt ccttatgaaa acatcgataa agtcgttcaa aaaaagaaac 3824941 tatggtccgg ttttcgtctg atcggctctc gccatgccat cacaatatat tatcaggggg 3825001 gatggggaca tgcagtaatt tcaccgcaaa aatctgaaga atttatccac aagctcaaag 3825061 aaaagaattc taatataata atattcacta aaagtaagtg attacctttt gttaaaaata 3825121 taaaaagctc tcctgctttt caggagagct tctattttgg tatgcgaatc gttaattgaa 3825181 tatattcttc aaattcttct tcttccgtat tcaattttac accgctgtct tccaccattg 3825241 atagtgactg gcgaatcgtg ttcatcgcaa ttcttgtatc tctgctgaat gctttgcgtc 3825301 tcggctttgg ctttctctgg ccttgctcca gcattttcac cacgcggtct tctgtctgct 3825361 ttacatttaa acttttctca ataatctctg tgagcagtgt gacttggagc tcaggctgtt 3825421 tcagcggaat cagtgctctg gcatggcgct cggtgatttt cttctccata atcgcctctt 3825481 ggaccggctg aggcagcttt aataaccgaa gcttattcgc gattgtagac tgcccttttc 3825541 ctaagcgctg tgcgagtgcc tcctgtgtta aatcatgcag ctcaagcagc ctagcataag 3825601 catgcgcttc ctcaatagaa gacagttctt cccgctgcaa gttttcgatt aacgccacag 3825661 aagcggtttc cgtgtcggaa aaatccttaa taattgccgg aatcttttcc cactcaagcg 3825721 attgcaccgc tctccagcgt ctttcacctg caatgagttc gtattggcct tcttcttctg 3825781 tatgcctaac aacaatcggc tgaataatgc cgtgtgtatg aatggtcatt gctaactctt 3825841 tgattttttc atctgagaaa atggtgcgtg gctgaaaacg gttgggaacg atagcattta 3825901 ccggtatttc cagaatctct tctttgtttg tatcatgttc agcaatctcc ggctcctgtt 3825961 ccttctcacc aagcccgaag aaacgagaga atgaatgctt catgtaccta caccaccttt 3826021 aaaaactgcc atttttataa ttctattttc tcatggtttt tcctgctgta catccatcaa 3826081 ttttgatgaa aatatgatgg tattgtcata tcaggctgtc taaattaccc ttcaattggc 3826141 gatttattag gagttcccgg ttttcttgga tacttcttag gtgtattttt tattttgcgt 3826201 atcaccataa tattacgatc gctttcttca ataggcagct taaaagaatg gatattctca 3826261 agttctcctc caagcgtcgt gattgctttt ttgcctgcat tcagttcttc ttcagctgat 3826321 gcggctttta aagcaacaaa taaaccgttt ttcttcacca gaggcaagca aagctcactc 3826381 aaaacagata atctcgcaac tgcgcgcgcc gtcacaatat catagctttc acgcacgtct 3826441 ttccgttgcc cgaacgtttc agctctgtca tggcagaatg ttgtattctc caattgcaaa 3826501 gcttcagaca acttttctaa aaacgtaatc cgtttgttta gtgaatccac gattgtgaca 3826561 tggaggtgcg gaaagcatat ttttatcggc agacttggaa aacccgctcc cgctccaaca 3826621 tcacaaatcg tgttcacctg attgaagtcg acataaaaag cagctgtaat ggaatcataa 3826681 aaatgcttta aatacacttc ttttttctct gttattgaag tcagattgat tttttcgttc 3826741 cattcaacca gcatgtcgta atacagctca aattgctcca gctgacgggg agaaagggag 3826801 atcccttttt ccgccaaacc agaagtgaat tcttcaatat tcatgccgtc atcctttcta 3826861 ctcggctatc ttcgcaatgc gtccctgctc taaatacacc aatagaattg aaatgtccgc 3826921 cgggtttaca ccggaaatgc gggaagcctg ggcaacagac aaaggccgta catttttcag 3826981 tttttgacgc gcctcggtcg caatcccctt aattgcgtca taatcaattc ggtctggaat 3827041 ttttttattt tccatcttct tcagtttttc cacttgctga agagattttt caatatatcc 3827101 ttcatatttc acttggattt ctacttgttc tgccacgtct tgaggaaccg gcacttctgg 3827161 cggcgccagt tttgtgactg tttcatagtt catttcagga cgtttcatca agtctgtgcc 3827221 gcgaactcca tctttcaatt cgcttccgcc aagagaacgg atatattctt gattttccgg 3827281 agacggcttg ataattacag aatgaagacg ttttttctcc gcctcgatcg ccgctttttt 3827341 cttctcaaaa gccgcatagc gctcatcaga aatcaatcca atgcgatgtc cgatttctgt 3827401 cagacgcaaa tcagcattgt catggcgaag cagcaatctg tattccgcac gtgatgtcaa 3827461 aagacgatat ggctcattgg taccttttgt cacaaggtca tcaatcagaa caccaatata 3827521 ggcgtcagaa cggcttagaa ttacttcttc ttttccaagc gcttttcgtc ctgcattgat 3827581 tcccgccata atcccttgtc ccgcagcttc ttcataaccg gatgttccgt taatttggcc 3827641 tgcagtataa aggtttgtga tttttttggt ttcaagtgtc ggccatagct gtgtcggtac 3827701 gattgcatca tactcgatcg catagccggc tctcatcatt tgcacgtttt caagtccagg 3827761 aatcgttgca agcattcttt gctgtacgtc ttctggaaga cttgtagata aaccttggac 3827821 atagacttcc tgtgtatttc tgccttccgg ctcaaggaag atttggtgac gcggtttatc 3827881 attaaaacgg acaactttgt cttcaatgga tgggcagtat cttgggcccg tacctttgat 3827941 cataccggaa tacatcggtg aacggtgcag gttgctgtca ataatctcat gtgtctcagg 3828001 gcttgtatat gtcagccagc aagggagctg atctgtgata tattccactg tttcatatga 3828061 gaaagcgcga ggcacatcgt caccaggctg aatttccgtt ttgctgtaat caatcgtgtc 3828121 gcttttaacg cgaggcggcg tacctgtttt aaaacgaaca aggtcaaaac cgagttcctc 3828181 caaatgctca gaaagcttaa tagaaggctg ctggttattc gggccgcttg agtaagacag 3828241 atcgccaaga atgatacgtc ctcttaaata tgtccctgtc gtcatgacaa ctgctttcgc 3828301 acgataatgt gcgcctgttt gtgtaataac gcctcggcat tcgccgtctt caacgatcag 3828361 ccgctccaca attccttgca gcaatgttaa gtttggttct ttttcaagcg tatttttcat 3828421 ttcgtgctga tattggaatt tgtctgcttg cgcacgcaat gcacgaaccg caggaccttt 3828481 tcctgtattc agcattctca tttgaatatg tgttttatcg atgtttcttc ccatttctcc 3828541 gccgagcgcg tcaatttcgc ggacgacaat cccttttgcg gggccgccga cagacggatt 3828601 acatggcata aatgcaacca tatctaggtt gatggtcaag acaagcgttt tggcgccttg 3828661 gcgtgcagat gcgagggcag cctcaacacc ggcatgcccg gcgccaatca caatcacatc 3828721 gtattggcct gcttcatacc ccatgattct agttcctcct ttaattattt tcctaaacag 3828781 aattgagaaa agagctgatc aattaagctt tcgtggacag aatctccaat gatttcccct 3828841 aaaagctccc agcatcttgt aaggtcaatt tgcaccatgt cgatcgggac atcctgttcg 3828901 atgccgctaa gcgcatcttc aatggcgcgt tttgcttgct gtaaaatagt gatgtgacgt 3828961 gtgttgctga cataagtcag atcaccgctt tcaatggcac ccgtgtagaa cagtgattga 3829021 atcgcttctt ccagatcatt gatgccttcc tcttttaaaa gagatgtcgt aacaactgga 3829081 cgtccattgg caagctcacg gacacgttca gtgtcaatct tcggctcaag gtcagtctta 3829141 ttcaaaatca cgataacatc catgccctca acggcttcaa aaagcttcac gtcttcttca 3829201 gaaagctctt cactataatt aagcacaagt aaaatcaggt ccgcttcctt taggacctgg 3829261 cgagaacgtt caacaccgat tcgctcaaca atatcctctg tttcacgaat acctgctgta 3829321 tcaaccagac gaagcggaac gccccttaca ttcacgtatt cctcaatcac atcccgtgtc 3829381 gttccgggaa tatcggttac aatggctttt gcctcatgaa cgaggctgtt cagaagagat 3829441 gattttccta cgtttggccg gccgataatg acggtagaaa gaccttcacg caagattttt 3829501 ccttgctcag aagtcctcag cagcgtctca atttcctttt tcacggcggt tgccttttcg 3829561 actaaaatct gatgcgtcat ttcctctaca tcatcatact ccggataatc aatattcacc 3829621 tcaacatggg ccagtgtttc taaaatctca ctgcgcaaac ggcgcaccaa agcagaaaga 3829681 cgcccttcca tttgattcat agcaacgttc attgcccggt ccgttttcgc tctgattaag 3829741 tccataaccg cttccgcctg tgaaagatcg attcggccgt ttaaaaacgc acgtttcgta 3829801 aattcaccag gctctgccag tctcgctccc tctctcaatg caagctgaag cacttggttc 3829861 acagtcacaa ttcccccgtg acagttaatc tcgatgacat cttctcgtgt aaaagttctc 3829921 ggcgctttta acactgatac cattacttcc tcaacgacac gatccgaagg tctgtctacg 3829981 atatgaccat aatgaatcgt atgtgattcg accgagctga gtgttttccc cttcggtccc 3830041 ttataaattt tatctgcgat ttgaatggct tctggtccgc tcaaccgtac aatcgcaatc 3830101 gcgccttctc ccatcggtgt ggaaattgcc gcaattgtat ccatgttgtt cacctctctt 3830161 tacttatact tcatctatat aaaaaaattt ttattatgcc aaaactaaaa gataacatag 3830221 tttggttcga agtggaagat ttgttatcca cagaaataga aattcgtccc ttattacttt 3830281 aacttatcca catgtgaata acaattaatt ttatttcctg aacttccttt ttatcaacag 3830341 gatacaccta aaaagaaaaa acttaaacgg caaaaccttg atattactag gaaaagtaga 3830401 tttttcggat acaaaaaaac cgaaatccaa tttttatcgg acttcggttt tatgctatct 3830461 tttatgggaa ataacgagat gacgattttc gccttcaccc attgaatatg ttttgatctg 3830521 gtggtttgca tatccagaaa gagtatcgtg aataattttt ctttcgctgg acggcatggg 3830581 ctcaagctgg atggattttt tcgttttcaa aacctggtca gcaagcttga tggccagctg 3830641 gctcagtgtt tcttttcttt tcaaacgata gttttctgca tccaccgtca catttttata 3830701 ttggcctgga taacggttaa gggcaagctg tgtcaaagtt tcaagggcgt ttaaagtttg 3830761 tcctcttttc ccaatcaaca atgctgcctt ttcacctgtt atatgatatc tcactgtctt 3830821 tttgctttct tgaacagtca catcagactt cccggcaatg gcttcggcaa tcgtttgaag 3830881 atataacttc gcttgctgaa tcggatcaat cttttcaacc agctttacga tcgcaggctt 3830941 tttaccgaaa ataccgagaa accctttgtt tccctcttca ataacagtaa tttctacctt 3831001 atccttcgtt aatcccaact cttgcaatcc ggactgtact gcttcatcga catttcgccc 3831061 tgcagcagtc acattcctca ctttttcttt cctccggctt tttgcggctc aggatttttt 3831121 ttaatatcag gtcctttaat gaggaaagtt tgcgcaatca taaacaagtt accaactacc 3831181 caataaagag aaagagccgc cgggaagttg atcgcaaata cgataatcat aattggcata 3831241 atccaaagca tcatcgccat ttgcggattt tgctgcgcat tgccagccat catcagtttt 3831301 tgctgaacaa atgtagcgac accggcaacg ataggaagaa tatagtaagg atctttttct 3831361 cctaagtcaa accataagaa gctatgctct gaaatcgcct gggttctcat gatcgcatga 3831421 tagaatccaa ttaaaatcgg catctggatc aaaatcggga aacatcccgc caatggattg 3831481 acaccatgct tttggaataa agccattgtt tcctgttgaa gcttttgctg cgttttttga 3831541 tcctttgagc tgtatttttc tttaagcttt tgcatttccg gctgtaaagc ctgcatcgct 3831601 ttcgaacttc tcagctgctt aatcatcagc ggtaaaatta ataaacgaat taaaatggta 3831661 actagaataa ttgaaagccc gtagttatct cccgtcaatt tcgctacata cgtaatgagc 3831721 tcagacaatg gatatactac gtacttgtcc cagaaatgcg gactatctgc agtgatcggc 3831781 tctttcacac tcgagcatcc agccaaaagc atgaatacgc caaccatact taatagcaac 3831841 cctattctcc ttttcaacaa catttcctcc tataattaat ctttacactc ttttattgca 3831901 aagcatactt gtatgtattt tagcatcttt cagttttaaa tggtgtcttt ttctgatcaa 3831961 ccagaaagga agcgctttta aaagttgtaa gaaagcagtg gtgatgccta ctttgacgaa 3832021 gatttcttat ataatgaaga ctttctgaat agatgctgca gacttttttt cgtttcctca 3832081 tatgtcagct ggctcgccgg ttttctggca ataatgatgt aatccttttc cttcagtctc 3832141 tctttctctt caagaaaggc ctgccgaatc aaacgtttga tccgatttcg catcacagca 3832201 ttgccaattt ttttgctgac ggaaagcccg acacgcagtt catcattttc aggctgatca 3832261 agcgtatata agacaaactg gcggtttgca actgatgtcc catgtttaaa cactttttga 3832321 aaatcttcat ttttctttaa acgatttcgc ttcttcaaat gactcactcc gatactggct 3832381 ggcagaaact tttaaaattt attatgaaca tgagatgcat ctgaaccagg aagcatgccc 3832441 cggttcatta cgcatcacat ctatcttttc ccataacgtg aaaaaagacc actgacatta 3832501 ttcagtggcc taagctgata atacttttct gcctttgcgg cgacggcgtg ctaaaactag 3832561 acgaccgttt tttgaactca tacggcttct gaagccatga actttgctgc gtttacggtt 3832621 attcggttgg aatgttcttt tcatttatga cacctccctc gaggaatagc tgttaaagac 3832681 agtcttactt attatatttg cgttacctat tcattgtcaa cttcactagt gcttttattt 3832741 cttgcaacca taataggata ccataccttt tcaactttcg aaaccttatt ttttagattc 3832801 cttaatttta cggaaaaaag acaaattcaa acaatttgcc cctaaaatca cgcatgtgga 3832861 tatctttttc ggcttttttt agtatccaca gaggttatcg acaacatttt cacattacca 3832921 acccctgtgg acaaggtttt ttcaacaggt tgtccgcttt gtggataaga ttgtgacaac 3832981 cattgcaagc tctcgtttat tttggtatta tatttgtgtt ttaactcttg attactaatc 3833041 ctacctttcc tctttatcca caaagtgtgg ataagttgtg gattgatttc acacagcttg 3833101 tgtagaaggt tgtccacaag ttgtgaaatt tgtcgaaaag ctatttatct actatattat 3833161 atgttttcaa catttaatgt gtacgaatgg taagcgccat ttgctctttt tttgtgttct 3833221 ataacagaga aagacgccat tttctaagaa aaggagggac gtgccggaag //